bluuebunny/crossref_metadata_2025_split huggingface dataset:
Echocardiographic versus angiographic measurement of the aortic valve annulus in children undergoing balloon aortic valvuloplasty: method affects outcomes
Authors: Nicholson George T. , Goldstein Bryan H. , Gao Kevin , Sachdeva Ritu , Lang Sean M. , Gillespie Scott , Kim Sung-in H. , Petit Christopher J. 
Published: October 2020

AbstractObjective:Operators are mindful of the balloon-to-aortic annulus ratio when performing balloon aortic valvuloplasty. The method of measurement of the aortic valve annulus has not been standardised.Methods and results:Patients who underwent aortic valvuloplasty at two paediatric centres between 2007 and 2014 were included. The valve annulus measured by echocardiography and angiography was used to calculate the balloon-to-aortic annulus ratio and measurements were compared. The primary endpoint was an increase in aortic insufficiency by ≥2 degrees. Ninety-eight patients with a median age at valvuloplasty of 2.1 months (Interquartile range (IQR): 0.2–105.5) were included. The angiographic-based annulus was 8.2 mm (IQR: 6.8–16.0), which was greater than echocardiogram-based annulus of 7.5 mm (IQR: 6.1–14.8) (p < 0.001). This corresponded to a significantly lower angiographic balloon-to-aortic annulus ratio of 0.9 (IQR: 0.9–1.0), compared to an echocardiographic ratio of 1.1 (IQR: 1.0–1.1) (p < 0.001). The degree of discrepancy in measured diameter increased with smaller valve diameters (p = 0.041) and in neonates (p = 0.044). There was significant disagreement between angiographic and echocardiographic balloon-to-aortic annulus ratio measures regarding “High” ratio of >1.2, with angiographic ratio flagging only 2/12 (16.7%) of patients flagged by echocardiographic ratio as “High” (p = 0.012). Patients who had an increase in the degree of aortic insufficiency post valvuloplasty, only 3 (5.5%) had angiographic ratio > 1.1, while 21 (38%) had echocardiographic ratio >1.1 (p < 0.001). Patients with resultant ≥ moderate insufficiency more often had an echocardiographic ratio of >1.1 than angiographic ratio of >1.1 There was no association between increase in balloon-to-aortic annulus ratio and gradient reduction.Conclusions:Angiographic measurement is associated with a greater measured aortic valve annulus and the development of aortic insufficiency. Operators should use caution when relying solely on angiographic measurement when performing balloon aortic valvuloplasty.
A fully-textile wideband AMC-backed antenna for wristband WiMAX and medical applications
Authors: El Atrash Mohamed , Abdalla Mahmoud A. , Elhennawy Hadia M. 
Published: October 2020

AbstractProposed is a wideband, low profile, fully flexible, and all-textile-based slotted triangular antenna loaded with a 2 × 2 textile-inspired artificial magnetic conductor to be worn on the wrist. The integrated antenna design is designed to cover the frequency band from 3.1 to 6.5 GHz. The integrated design has two main resonances, where the first one is at 3.5 GHz, which can serve the WiMAX communication standard, while the second is at 5.8 GHz, which can serve the Industrial, Scientific and Medical (ISM)-band. The incorporated textile materials are composed of the conductive and dielectric fabrics that are realized by ShieldIt and Felt, respectively. When simulated against the human model wrist, the integrated antenna design displayed a realized gain of 6.71 dBi and radiation efficiency of 79.1%, at 3.5 GHz. Furthermore, at 5.8 GHz, it displayed a realized gain of 7.82 dBi and total efficiency performances of 66.1%. Moreover, it accomplished very low SAR levels within the antenna frequency band. Averaged over 1 g of tissue, it exhibited maximum SAR levels of 3.28 × 10−6 and 9.37 × 10−7 W/kg at 3.5 and 5.8 GHz, respectively. For the bent scenarios, the integrated antenna design displayed robustness when bent at an angle of 20 and 40°. Finally, measurement results are illustrated and analyzed. Based on the presented results, the suggested all-textile integrated antenna design might be designated for integration with the wristband to monitor the user health conditions through many possible frequency channels.
Indonesia's Position in Asia: Increasing Soft Power and Connectivity through the 2018 Asian Games
Authors: Trotier Friederike 
Published: October 2020

AbstractHosting a sports mega-event strengthens connectivity with the world and provides opportunities to establish or increase networks and to build soft power. These events operate as hubs for the global flow of capital, people, knowledge and technology, and they perform important rituals and symbolic functions. In particular, they become coveted opportunities to enrich the soft power portfolio of governments or individual leaders. Despite its regional character, the Asian Games have developed into such a mega-event. In 2018 – only for the second time in the history of the Asian Games – Indonesia staged the event in Jakarta and Palembang. This paper scrutinises the ways in which Indonesia used or failed to use the Asian Games as a platform to increase the country's soft power and reputation and to strengthen intra-Asian connectivity. Three aspects serve as examples to assess Indonesia's soft power initiatives: (1) the “spirit of 1962”, (2) the host country's emergence on the Asian stage and (3) Indonesia's cooperation with other countries and intra-Asia connections in the context of the sports event. Examining the prominence of domestic politics reveals shortcomings and untapped potential. The analysis shows that the inward-looking foreign policy approach of the Jokowi administration limited the initiatives to increase Indonesian soft power and to establish and address Asian themes and debates; consequently, this approach downgraded the sports event to a tool to generate political capital for domestic affairs.
Go East! 1905 as a Turning Point for the Transnational History of Vietnamese Education
Authors: Legrandjacques Sara 
Published: October 2020

AbstractThis paper discusses the year 1905 as an educational watershed in colonial Vietnam. It focuses on the development of student mobility that transcended colonial and imperial boundaries and gave new momentum to educational training on a transnational scale. In the mid-1900s, the anti-colonial mandarin Phan Bội Châu launched a new nationalist movement calledĐông Du, meaning ‘Going East.’ It centred on sending young men to Japan via Hong Kong to train them as effective anti-French activists. These students came from Tonkin, Annam, and Cochinchina and enrolled in a variety of curricula. Although this initiative collapsed in the late 1900s, it remained a watershed. Regional mobility did not disappear afterwards but mostly redirected itself towards China. This paper brings a great diversity of material face-to-face, including governmental archives and biographies, and challenges the colonial-based vision of Vietnamese education by highlighting its regional dimension, from the early twentieth century to the outset of the Second World War.
Comparison of aminocyclopyrachlor to standard herbicides for basal stem treatment of Eucalyptus benthamii
Authors: Minogue Patrick J. , Lorentz Kimberly A. 
Published: October 2020

AbstractEucalyptus species are grown for fiber, fuel, and other uses on more than 17.8 million ha worldwide, yet some species are considered invasive and may have adverse environmental or social impacts outside their native range. Aminocyclopyrachlor (AMCP) and standard applications of imazapyr and triclopyr herbicides were compared for eucalyptus control using a basal stem application method. At 6 and 12 mo after treatment (MAT), basal stem applications using 5% (vol/vol) AMCP (120 g ae L−1) in methylated soybean oil (MSO) resulted in 97% to 99% eucalyptus crown reduction and generally provided greater control across all diameter classes than standard treatments of 28% imazapyr (240 g ae L−1) or 75% triclopyr ester (480 g ae L−1). AMCP at 5% was as effective as 40% vol/vol. Increases in stem live height at 24 MAT suggest that the effect of triclopyr ester basal stem treatment may be impermanent. AMCP treated trees did not have regrowth by 24 MAT.
Angular Dependence and Spatial Distribution of Jupiter's Centimeter‐Wave Thermal Emission From Juno's Microwave Radiometer
Authors: Oyafuso Fabiano , Levin Steven , Orton Glenn , Brown Shannon T. , Adumitroaie Virgil , Janssen Michael , Wong Michael H. , Fletcher Leigh N. , Steffes Paul , Li Cheng , Gulkis Samuel , Atreya Sushil , Misra Sidharth , Bolton Scott 
Published: October 2020

AbstractNASA's Juno spacecraft has been monitoring Jupiter in 53‐day orbits since 2016. Its six‐frequency microwave radiometer (MWR) is designed to measure black body emission from Jupiter over a range of pressures from a few tenths of a bar to several kilobars in order to retrieve details of the planet's atmospheric composition, in particular, its ammonia and water abundances. A key step toward achieving this goal is the determination of the latitudinal dependence of the nadir brightness temperature and limb darkening of Jupiter's thermal emission through a deconvolution of the measured antenna temperatures. We present a formulation of the deconvolution as an optimal estimation problem. It is demonstrated that a quadratic expression is sufficient to model the angular dependence of the thermal emission for the data set used to perform the deconvolution. Validation of the model and results from a subset of orbits favorable for MWR measurements is presented over a range of latitudes that cover up to 60° from the equator. A heuristic algorithm to mitigate the effects of nonthermal emission is also described.
Detectability of Artificial Ocean Alkalinization and Stratospheric Aerosol Injection in MPI‐ESM
Authors: Fröb Friederike , Sonntag Sebastian , Pongratz Julia , Schmidt Hauke , Ilyina Tatiana 
Published: October 2020

AbstractTo monitor the success of carbon dioxide removal (CDR) or solar radiation management (SRM) that offset anthropogenic climate change, the forced response to any external forcing is required to be detectable against internal variability. Thus far, only the detectability of SRM has been examined using both a stationary and nonstationary detection and attribution method. Here, the spatiotemporal detectability of the forced response to artificial ocean alkalinization (AOA) and stratospheric aerosol injection (SAI) as exemplary methods for CDR and SRM, respectively, is compared in Max Planck Institute Earth System Model (MPI‐ESM) experiments using regularized optimal fingerprinting and single‐model estimates of internal variability, while working under a stationary or nonstationary null hypothesis. Although both experiments are forced by emissions according to the Representative Concentration Pathway 8.5 (RCP8.5) and target the climate of the RCP4.5 scenario using AOA or SAI, detection timescales reflect the fundamentally different forcing agents. Moreover, detectability timescales are sensitive to the choice of null hypothesis. Globally, changes in the CO2 system in seawater are detected earlier than the response in temperature to AOA but later in the case of SAI. Locally, the detection time scales depend on the physical, chemical, and radiative impacts of CDR and SRM forcing on the climate system, as well as patterns of internal variability, which is highlighted for oceanic heat and carbon storage.
Influence of Inflow Density and Temperature Asymmetry on the Formation of Electron Jets during Magnetic Reconnection
Authors: Montag Peter , Egedal Jan , Daughton William 
Published: October 2020

AbstractThe structure of the electron diffusion region (EDR), fundamental to a comprehensive theory of magnetic reconnection, is highly sensitive to asymmetry in the plasma parameters across the reconnection current layer. Using known scaling laws for the inflow region electron pressure anisotropy, a model is developed to predict the formation of extended electron jets within the EDR. Confirmed by kinetic simulation, the analysis shows how embedded electron jets are driven for scenarios fulfilling a generalized symmetry conditions based on the marginal firehose condition.
Seafloor Depth of George VI Sound, Antarctic Peninsula, From Inversion of Aerogravity Data
Authors: Constantino Renata R. , Tinto Kirsty J. , Bell Robin E. , Porter David F. , Jordan Tom A. 
Published: October 2020

AbstractGeorge VI Sound is an ~600 km‐long curvilinear channel on the west coast of the southern Antarctic Peninsula separating Alexander Island from Palmer Land. The Sound is a geologically complex region presently covered by the George VI Ice Shelf. Here we model the bathymetry using aerogravity data. Our model is constrained by water depths from seismic measurements. We present a crustal density model for the region, propose a relocation for a major fault in the Sound, and reveal a dense body, ~200 km long, flanking the Palmer Land side. The southern half of the Sound consists of two distinct basins ~1,100 m deep, separated by a −650 m‐deep ridge. This constricting ridge presents a potential barrier to ocean circulation beneath the ice shelf and may account for observed differences in temperature‐salinity (T‐S) profiles.
Correlation Between Poroelastic Stress Perturbation and Multidisposal Wells Induced Earthquake Sequence in Cushing, Oklahoma
Authors: Deng Kai , Liu Yajing , Chen Xiaowei 
Published: October 2020

AbstractOver 100 small‐ to moderate‐sized earthquakes, including an Mw 5.0 event, were detected during September 2015 to November 2016 near the town of Cushing, Oklahoma. The seismic sequence was spatial‐temporally linked to four wastewater disposal wells within 4 km. We calculate pore pressure and stress perturbations caused by fluid injection at multiple wells and analyze seismic risk in a Coulomb failure stress framework. Despite being more than an order of magnitude smaller than the pore pressure perturbation, the sign of shear stress change, in the sense of assumed right‐lateral fault motion, dictates where earthquakes are induced. Most of the relocated earthquakes are located within areas of positive shear stress changes. Our results suggest that poroelastic stress changes also play an essential role in the wastewater disposal environment, and a strategic design of well locations with respect to fault orientation and direction of motion can help mitigate induced seismic hazard.
Minimal Climate Impacts From Short‐Lived Climate Forcers Following Emission Reductions Related to the COVID‐19 Pandemic
Authors: Weber James , Shin Youngsub M. , Staunton Sykes John , Archer‐Nicholls Scott , Abraham N. Luke , Archibald Alex T. 
Published: October 2020

AbstractWe present an assessment of the impacts on atmospheric composition and radiative forcing of short‐lived pollutants following a worldwide decrease in anthropogenic activity and emissions comparable to what has occurred in response to the COVID‐19 pandemic, using the global composition‐climate model United Kingdom Chemistry and Aerosols Model (UKCA). Emission changes reduce tropospheric hydroxyl radical and ozone burdens, increasing methane lifetime. Reduced SO2 emissions and oxidizing capacity lead to a decrease in sulfate aerosol and increase in aerosol size, with accompanying reductions to cloud droplet concentration. However, large reductions in black carbon emissions increase aerosol albedo. Overall, the changes in ozone and aerosol direct effects (neglecting aerosol‐cloud interactions which were statistically insignificant but whose response warrants future investigation) yield a radiative forcing of −33 to −78 mWm−2. Upon cessation of emission reductions, the short‐lived climate forcers rapidly return to pre‐COVID levels; meaning, these changes are unlikely to have lasting impacts on climate assuming emissions return to pre‐intervention levels.
A Local Particle Filter Using Gamma Test Theory for High‐Dimensional State Spaces
Authors: Wang Zhenwu , Hut Rolf , Van de Giesen Nick 
Published: October 2020

AbstractParticle filters are non‐Gaussian filters, which means that the assumption that the error distribution of the ensemble should be Gaussian is unnecessary. Like the ensemble Kalman filter, particle filters are based on the Monte Carlo approximation to represent the distribution of model states. It requires a substantial number of particles to approximate the probability density function of states in high‐dimensional models, which is prohibitive for real applications. In order to overcome problems with high dimensionality, localization was applied in an Ensemble‐type data assimilation system. This study combines the localization in LETKF (Local Ensemble Transformation Kalman Filter) with particle filters and proposes a new local particle filter with the model state space correction using Gamma test theory for high‐dimensional models. A series of tests with various parameter settings, including different the numbers of particles, observation intervals, localization scale, inflation factors, and observation operators, were used to evaluate the performance of this new method using a Lorenz model with 40 variables. Besides, the proposed filter was applied in the Lorenz model with 1,000 variables to evaluate its performance in the model with higher dimensions. The results show that this approach can deal with the issue of dimensionality, which otherwise leads to the collapse of the particle filters in high‐dimensional systems. The local particle filter is stable and has considerable potential for complex higher‐dimensional models.
Structural Evolution of Orogenic Wedges: Interplay Between Erosion and Weak Décollements
Authors: Dal Zilio Luca , Ruh Jonas , Avouac Jean‐Philippe 
Published: October 2020

AbstractOrogenic wedges commonly display an inner wedge, where crystalline units have been exhumed, and an outer wedge formed by imbricated sedimentary units detached from the basement. Analog experiments have shown that similar structures can emerge naturally in the presence of weak décollements due to the interplay between erosion and deformation. In this study, we further investigate this hypothesis using two‐dimensional, visco‐elasto‐plastic numerical models. Our experiments assume a basal and an intermediate décollement within the wedge. Experiments with a frictional strength of the basal décollement lower or equal to that of the intermediate décollement show a structural evolution of fold‐and‐thrust belts dominated by out‐of‐sequence thrusting. Conversely, when the intermediate décollement is weaker than the basal décollement, distinct outer and inner wedges are formed. This process leads to episodic migration of midcrustal ramps, tectonic underplating, and antiformal stacking facilitated by erosion. Comparison between our models and the Himalayan wedge suggests a low effective friction (∼0.10), which is probably due to dynamic weakening during large (M8+) Himalayan earthquakes. The deeper décollement, along which the lower plate thrusts beneath the High Himalaya, must be a thermally activated ductile shear zone with an apparent friction of ∼0.18. Fold‐and‐thrust belts worldwide exhibit various architectures in which different décollement levels might be activated. Thus, our study provides a framework to help assess under which conditions a variety of structures observed in orogenic systems can arise.
Evogliptin, a dipeptidyl peptidase-4 inhibitor, attenuates pathological retinal angiogenesis by suppressing vascular endothelial growth factor-induced Arf6 activation
Authors: Seo Songyi , Kim Mi-Kyung , Kim Ryul-I , Yeo Yeongju , Kim Koung Li , Suh Wonhee 
Published: October 2020

AbstractDipeptidyl peptidase-4 (DPP-4) inhibitors are used for the treatment of type 2 diabetes mellitus (DM). Recent studies have shown that beyond their effect in lowing glucose, DPP-4 inhibitors mitigate DM-related microvascular complications, such as diabetic retinopathy. However, the mechanism by which pathological retinal neovascularization, a major clinical manifestation of diabetic retinopathy, is inhibited is unclear. This study sought to examine the effects of evogliptin, a potent DPP-4 inhibitor, on pathological retinal neovascularization in mice and elucidate the mechanism by which evogliptin inhibits angiogenesis mediated by vascular endothelial growth factor (VEGF), a key factor in the vascular pathogenesis of proliferative diabetic retinopathy (PDR). In a murine model of PDR, an intravitreal injection of evogliptin significantly suppressed aberrant retinal neovascularization. In human endothelial cells, evogliptin reduced VEGF-induced angiogenesis. Western blot analysis showed that evogliptin inhibited the phosphorylation of signaling molecules associated with VEGF-induced cell adhesion and migration. Moreover, evogliptin substantially inhibited the VEGF-induced activation of adenosine 5′-diphosphate ribosylation factor 6 (Arf6), a small guanosine 5′-triphosphatase (GTPase) that regulates VEGF receptor 2 signal transduction. Direct activation of Arf6 using a chemical inhibitor of Arf-directed GTPase-activating protein completely abrogated the inhibitory effect of evogliptin on VEGF-induced activation of the angiogenic signaling pathway, which suggests that evogliptin suppresses VEGF-induced angiogenesis by blocking Arf6 activation. Our results provide insights into the molecular mechanism of the direct inhibitory effect of the DPP-4 inhibitor evogliptin on pathological retinal neovascularization. In addition to its glucose-lowering effect, the antiangiogenic effect of evogliptin could also render it beneficial for individuals with PDR.
Impact of angiotensin receptor blocker product recalls on antihypertensive prescribing in Germany
Authors: Rudolph Ulrike Maria , Enners Salka , Kieble Marita , Mahfoud Felix , Böhm Michael , Laufs Ulrich , Schulz Martin 
Published: October 2020

AbstractIn Germany, ~8 million patients take angiotensin receptor blockers (ARBs) and 2.25 million of them valsartan. In 2018, contamination of generic ARBs with probable carcinogenic nitrosamines resulted in more than 30 recalls. The impact of such a huge recall has never been explored in Europe. We analyzed the utilization of valsartan, all ARBs, and other alternative antihypertensive drugs in Germany. We used our database of anonymized dispensing data from >80% of community pharmacies at the expense of the statutory health insurance (SHI) funds from January 2017 to December 2019. We analyzed 290.8 million prescriptions, including all oral mono- and fixed-dose combinations of ARBs and plausible alternatives, i.e. ACE inhibitors (ACEi), beta-blockers (BB), and calcium channel blockers (CCB). Utilization was calculated by defined daily doses per 1000 SHI-insured persons per day (DID). Valsartan use decreased substantially after the recalls in July 2018 from 39.0 to 14.2 DID (−64%) in the second quarter of 2019 and to 16.9 DID (−57%) in the fourth quarter of 2019. Simultaneously, the use of alternative ARBs increased from 77.7 DID in the second quarter of 2018 to 121.9 DID (+57%) in the fourth quarter of 2019, mainly due to an increase of candesartan dispensing to 99.8 DID (+73%). There were no changes in the utilization of ACEi, BB, or CCB. The majority of recalled generic valsartan products were replaced by other ARBs, predominantly candesartan, despite documented drug shortages. In contrast to previous safety warnings/recalls, our data do not suggest an under-prescription of antihypertensives during this period.