bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions Among Native and Non-Native Predatory Coccinellidae Influence Biological Control and Biodiversity
Authors: Li Hongran , Li Baoping , Lövei Gábor L , Kring Timothy J , Obrycki John J 
Published: November 2020

AbstractOver the past 30 yr, multiple species of predatory Coccinellidae, prominently Coccinella septempunctata L. and Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) have spread to new continents, influencing biodiversity and biological control. Here we review the mechanisms underlying these ecological interactions, focusing on multi-year field studies of native and non-native coccinellids and those using molecular and quantitative ecological methods. Field data from Asia show that H. axyridis, C. septempunctata, and Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) are regularly among the most abundant predatory species but their rank varies by habitat. Studies of these species in their native Asian range, primarily related to their range in mainland China, document different patterns of seasonal abundance, species specific associations with prey, and habitat separation. Intraguild predation is well documented both in Asia and in newly invaded areas, and H. axyridis benefits most from this interaction. Harmonia axyridis also seems to rely more on cannibalism in times of prey scarcity than other species, and relatively sparse data indicate a lower predation pressure on it from natural enemies of coccinellids. Declines in the abundance of native coccinellids following the spread and increase of non-native species, documented in several multi-year studies on several continents, is a major concern for native biodiversity and the persistence of native coccinellid species. We suggest that future studies focus more attention on the community ecology of these invasive species in their native habitats.
Short-latency inhibition mitigates the relationship between conscious movement processing and overly cautious gait
Authors: Ellmers Toby J , Kal Elmar C , Richardson James K , Young William R 
Published: November 2020

Abstract

Background
Overly cautious gait is common in older adults. This is characterised by excessively slow gait, shortened steps, broadened base of support and increased double limb support. The current study sought to (1) evaluate if overly cautious gait is associated with attempts to consciously process walking movements, and (2) explore whether an individual’s ability to rapidly inhibit a dominant motor response serves to mitigate this relationship.

Methods
A total of 50 older adults walked at a self-selected pace on an instrumented walkway containing two raised wooden obstacles (height = 23 cm). Trait conscious movement processing was measured with the Movement-Specific Reinvestment Scale. Short-latency inhibitory function was assessed using a validated electronic go/no-go ruler catch protocol. We used linear regressions to explore the relationship between these variables and gait parameters indicative of overly cautious gait.

Results
When controlling for general cognitive function (MoCA), and functional balance (Berg Balance Scale), the interaction between trait conscious movement processing and short-latency inhibition capacity significantly predicted gait velocity, step length and double limb support. Specifically, older adults with higher trait conscious movement processing and poorer inhibition were more likely to exhibit gait characteristics indicative of cautious gait (i.e. reduced velocity, shorter step lengths and increased double limb support). Neither conscious movement processing nor inhibition independently predicted gait performance.

Conclusion
The combination of excessive movement processing tendencies and poor short-latency inhibitory capacity was associated with dysfunctional or ‘overly cautious’ gait. It is therefore plausible that improvement in either factor may lead to improved gait and reduced fall risk.
Basic Consideration for Facial Aging: Analyses of the Superficial Musculoaponeurotic System Based on Anatomy
Authors: Okuda Itsuko , Akita Keiichi , Komemushi Takayoshi , Irimoto Masahiro , Nakajima Yasuo 
Published: November 2020

Abstract

Background
The superficial musculoaponeurotic system (SMAS) is an important structure to understand for face-lift surgeries. However, the detailed distribution and imaging findings of the SMAS have not been established yet.

Objectives
The aim of this study was to establish the accurate distribution and computed tomography (CT) imaging findings of the SMAS based on cadaveric studies.

Methods
This study was designed in a 3-step procedure. First, 7 cadaver faces were utilized to understand the distribution and histology of the SMAS. Second, the SMAS findings from the cadaveric studies were compared with the CT images. Third, CT images were enrolled for the SMAS interpretation.

Results
In 7 cadaveric studies, the SMAS was observed as a subcutaneous fibro-membranous structure extending from the galea aponeurotica to the platysma muscle and laterally connected to the parotid fascia. On the medial side, it also connects with major and minor zygomatic muscles. The SMAS consisted of muscular fibers, collagen fibers, and elastic fibers histologically. Eighteen CT images (all females; age range, 21-82 years) showed the thin linear structures corresponding to the fibro-membranous structures in the cadaveric studies. CT density of the SMAS was similar with that of the muscle, and the SMAS was recognizable in all 18 subjects.

Conclusions
The SMAS is a definite anatomical structure that can be demonstrated as a thin membranous structure on CT. This clinical application could be applicable to the development the cosmetic surgical procedures.
The financialization of community development: the role of social finance
Authors: Huckfield Leslie 
Published: November 2020

Abstract
Local community organisations, many of which began life as agents of community self defence and regeneration during a Post-Fordist era of massive job losses in the 1970s and 1980s, are now being transposed into low-cost deliverers of public services in competition with the private sector. More recently, this process increasingly involves injections of “social finance” from external private sources. This article offers a brief history of how the voluntary and community sector has been corralled into a marketized and financialized role where the primacy of business management replaces community need. As in other spheres, there has been a paradigm shift from Keynesian demand management to a neoliberal perspective of community and voluntary organizations’ role in society where they gradually replace the state—in many cases with their encouragement and willing participation. As third sector organizations deliver public services, private investors are rewarded on a payment per output basis. Three case studies show how financialization through external shareholder interests is becoming a force in public service delivery.
Variability in Cardiac Biomarkers during Hemodialysis: A Prospective Cohort Study
Authors: Collister David , Mazzetti Andrea , Bhalerao Anuja , Tyrwhitt Jessica , Kavsak Peter , Brimble Kenneth S , Devereaux P J , Walsh Michael 
Published: November 2020

AbstractBackgroundThe effect of hemodialysis on cardiac biomarkers is unclear. We sought to evaluate the degree and causes of intradialytic variability of high sensitivity troponin I (hs-TnI), galectin-3 (gal-3), and heart-type fatty acid binding protein (hFABP).Methodshs-TnI, gal-3, and hFABP were prospectively measured pre-dialysis and post-dialysis for 1 week every month for 6 months in 178 prevalent adult hemodialysis patients at a single center in Hamilton, Canada. The degree of change from pre-dialysis to post-dialysis for each cardiac biomarker was estimated with multilevel linear regression models.ResultsThe median change in the concentration of hs-TnI during hemodialysis was −1 ng/L (interquartile range [IQR] −1 to 2 ng/L) while gal-3 and hFABP changed by −36.3 ng/mL (IQR −27.7 to −46.8 ng/mL) and −19.41 ng/mL (IQR −13.61 to −26.87 ng/mL), respectively. The median (IQR) percentage intradialytic changes for hs-TnI, gal-3, and hFABP were 2.6% (−4.4% to 12.5%), −59.8% (−54.7% to −64.8%) and −35.3% (−28.4% to −42.1%), respectively. Ultrafiltration was associated with an increase in concentration of hs-TnI, gal-3, and hFABP (mean 0.99 ng/L, 1.05 ng/mL, and 1.9 ng/mL per L ultrafiltration, respectively, P &lt; 0.001). Both gal-3 and hFABP concentrations decreased in association with the volume of blood processed (P &lt; 0.001) and with hemodialysis treatment time (P  = 0.02 and P  = 0.04) while hs-TnI concentration decreased only in association with hemodialysis treatment time (P  &lt; 0.001).ConclusionsUltrafiltration volume and hemodialysis treatment time influenced hs-TnI, gal-3, and hFABP concentrations during hemodialysis and should be considered when interpreting their measurement.
Let fever do its job
Authors: Wrotek Sylwia , LeGrand Edmund K , Dzialuk Artur , Alcock Joe 
Published: November 2020

AbstractAlthough fever is one of the main presenting symptoms of COVID-19 infection, little public attention has been given to fever as an evolved defense. Fever, the regulated increase in the body temperature, is part of the evolved systemic reaction to infection known as the acute phase response. The heat of fever augments the performance of immune cells, induces stress on pathogens and infected cells directly, and combines with other stressors to provide a nonspecific immune defense. Observational trials in humans suggest a survival benefit from fever, and randomized trials published before COVID-19 do not support fever reduction in patients with infection. Like public health measures that seem burdensome and excessive, fevers involve costly trade-offs but they can prevent infection from getting out of control. For infections with novel SARS-CoV-2, the precautionary principle applies: unless evidence suggests otherwise, we advise that fever should be allowed to run its course.Lay summary: For COVID-19, many public health organizations have advised treating fever with medicines such as acetaminophen or ibuprofen. Even though this is a common practice, lowering body temperature has not improved survival in laboratory animals or in patients with infections. Blocking fever can be harmful because fever, along with other sickness symptoms, evolved as a defense against infection. Fever works by causing more damage to pathogens and infected cells than it does to healthy cells in the body. During pandemic COVID-19, the benefits of allowing fever to occur probably outweigh its harms, for individuals and for the public at large.
High-density transposon libraries utilising outward-oriented promoters identify mechanisms of action and resistance to antimicrobials
Authors: Coward Chris , Dharmalingham Gopujara , Abdulle Omar , Avis Tim , Beisken Stephan , Breidenstein Elena , Carli Natasha , Figueiredo Luis , Jones David , Khan Nawaz , Malara Sara , Martins Joana , Nagalingam Nabeetha , Turner Keith , Wain John , Williams David , Powell David , Mason Clive 
Published: November 2020

ABSTRACT
The use of bacterial transposon mutant libraries in phenotypic screens is a well-established technique for determining which genes are essential or advantageous for growth in conditions of interest. Standard, inactivating, transposon libraries cannot give direct information about genes whose over-expression gives a selective advantage. We report the development of a system wherein outward-oriented promoters are included in mini-transposons, generation of transposon mutant libraries in Escherichia coli and Pseudomonas aeruginosa and their use to probe genes important for growth under selection with the antimicrobial fosfomycin, and a recently-developed leucyl-tRNA synthase inhibitor. In addition to the identification of known mechanisms of action and resistance, we identify the carbon–phosphorous lyase complex as a potential resistance liability for fosfomycin in E. coli and P. aeruginosa. The use of this technology can facilitate the development of novel mechanism-of-action antimicrobials that are urgently required to combat the increasing threat worldwide from antimicrobial-resistant pathogenic bacteria.
Synthetic Musk Compounds in Human Biological Matrices: Analytical Methods and Occurrence—A Review
Authors: Katuri Guru Prasad , Fan Xinghua , Kosarac Ivana , Siddique Shabana , Kubwabo Cariton 
Published: November 2020

Abstract
Extensive use of synthetic musk compounds (SMs) in numerous consumer and personal care products has resulted in direct human exposures via dermal absorption, inhalation of contaminated dust and volatilized fragrances, and oral ingestion of contaminated foods and liquids. SMs and their metabolites are lipophilic, hence commonly detected in various biological matrices such as blood, breast milk, and adipose tissue. Appropriate analytical techniques are needed to detect and quantify SMs in biological matrices to assess their potential effects on human health. Different methods to process and analyze SMs in biological matrices, including sample-pretreatment, solvent extraction, cleanup, and instrumental analysis, are presented in this review. The concentration levels of selected musk compounds in biological samples from different countries/regions are summarized. Finally, research gaps and questions pertaining to the analysis of SMs are identified and suggestions made for future research studies.
Novel CONCOMITANT mutations L932F and I936V in the Voltage-Gated Sodium Channel and Its Association With Pyrethroid Resistance inCulex quinquefasciatus(Diptera: Culicidae)
Authors: Sugiura Masaaki , Kimoto Fumiko , Itokawa Kentaro , Kasai Shinji 
Published: November 2020

AbstractHighly residual pyrethroids such as permethrin have been used for controlling mosquitoes that transmit infectious diseases. However, the selective pressure from such insecticides may result in cross-resistance against other pyrethroids used for household insecticides. In this study, we investigated the susceptibility of Culex quinquefasciatus Say collected from Brazil and Myanmar to permethrin in addition to four types of household pyrethroids. Both strains exhibited high resistance against all pyrethroids tested, indicating cross-resistance. Furthermore, we detected the knockdown resistance (kdr) mutations L932F+I936V in the voltage-gated sodium channel gene (VGSC) in the Brazilian strain. Notably, the L932F+I936V haplotype has previously been observed in in silico data, but it should be detected not directly from living insects. In comparison, a common kdr mutation, L1014F, was detected from the Myanmar strain. Although L1014F was also detected from the Brazilian strain, the allele frequency was too low to affect resistance. Both strains harbored the resistance-associated haplotypes of the cytochrome P450 gene, CYP9M10. The Brazilian strain demonstrated comparable resistance against pyrethroids as that of the Myanmar strain even when a cytochrome P450 inhibitor, piperonyl butoxide was added to the bioassay. Our results suggested that the L932F+I936V mutations confer the Brazilian strain of Cx. Quiquefasciatus with resistance at a comparable level to that conferred by the well-recognized kdr mutation L1014F in the Myanmar strain. The identification of unexplored mutations may improve the diagnosis and understanding of resistance of this medically important species.
Preliminary analysis of prostate positional displacement using hydrogel spacer during the course of proton therapy for prostate cancer
Authors: Sato Hiroki , Kato Takahiro , Motoyanagi Tomoaki , Takemasa Kimihiro , Narita Yuki , Kato Masato , Matsumoto Takuya , Oyama Sho , Yamaguchi Hisashi , Wada Hitoshi , Murakami Masao 
Published: November 2020

AbstractIn recent years, a novel technique has been employed to maintain a distance between the prostate and the rectum by transperineally injecting a hydrogel spacer (HS). However, the effect of HS on the prostate positional displacement is poorly understood, despite its stability with HS in place. In this study, we investigated the effect of HS insertion on the interfraction prostate motion during the course of proton therapy (PT) for Japanese prostate cancer patients. The study population consisted of 22 cases of intermediate-risk prostate cancer with 11 cases with HS insertion and 11 cases without HS insertion. The irradiation position and preparation were similar for both groups. To test for reproducibility, regular confirmation computed tomography (RCCT) was done four times during the treatment period, and five times overall [including treatment planning CT (TPCT)] in each patient. Considering the prostate position of the TPCT as the reference, the change in the center of gravity of the prostate relative to the bony anatomy in the RCCTs of each patient was determined in the left–right (LR), superior–inferior (SI) and anterior–posterior (AP) directions. As a result, no significant difference was observed across the groups in the LR and SI directions. Conversely, a significant difference was observed in the AP direction (P &lt; 0.05). The proportion of the 3D vector length ≤5 mm was 95% in the inserted group, but 55% in the non-inserted group. Therefore, HS is not only effective in reducing rectal dose, but may also contribute to the positional reproducibility of the prostate.
Properties of Markov Chain Monte Carlo Performance across Many Empirical Alignments
Authors: Harrington Sean M , Wishingrad Van , Thomson Robert C 
Published: November 2020

AbstractNearly all current Bayesian phylogenetic applications rely on Markov chain Monte Carlo (MCMC) methods to approximate the posterior distribution for trees and other parameters of the model. These approximations are only reliable if Markov chains adequately converge and sample from the joint posterior distribution. Although several studies of phylogenetic MCMC convergence exist, these have focused on simulated data sets or select empirical examples. Therefore, much that is considered common knowledge about MCMC in empirical systems derives from a relatively small family of analyses under ideal conditions. To address this, we present an overview of commonly applied phylogenetic MCMC diagnostics and an assessment of patterns of these diagnostics across more than 18,000 empirical analyses. Many analyses appeared to perform well and failures in convergence were most likely to be detected using the average standard deviation of split frequencies, a diagnostic that compares topologies among independent chains. Different diagnostics yielded different information about failed convergence, demonstrating that multiple diagnostics must be employed to reliably detect problems. The number of taxa and average branch lengths in analyses have clear impacts on MCMC performance, with more taxa and shorter branches leading to more difficult convergence. We show that the usage of models that include both Γ-distributed among-site rate variation and a proportion of invariable sites is not broadly problematic for MCMC convergence but is also unnecessary. Changes to heating and the usage of model-averaged substitution models can both offer improved convergence in some cases, but neither are a panacea.
Executive pensions and the pay–performance relation—Evidence from changes to pension legislation in the UK
Authors: Morris Damon , Gregory-Smith Ian , Main Brian G M , Montagnoli Alberto , Wright Peter W 
Published: November 2020

Abstract
This article evaluates the role of executive pensions in the relationship between executive compensation and corporate performance. As a natural experiment, we exploit a major change to the tax-free allowances governing executive pensions. This reform affected the cost of pensions for firms whose executives had accumulated pension benefits in excess of the prescribed limit. We find a strong reaction to the reform. After 6 April 2006, many executives saw their defined benefit pension schemes replaced with risk-free cash payments. This imposition of an exogenous constraint on the contracting over CEO pay significantly decreased the relationship between executive pay and firm performance.
Marijuana: From Reefer Madness to THC Gummy Bears
Authors: Winter Jerrold 
Published: November 2020

Abstract
No substance better exemplifies the ambivalence of Western societies toward psychoactive drugs than marijuana. In 2017, it was estimated that there were more than 22 million current users, about 6.7% of the adult population, in the United States. For those aged 18 to 25, the figure was nearly 20%. In the United Kingdom, the prevalence of recreational use of marijuana among males aged 16–34 was put at 15.5%. Despite its widespread acceptance, many regard marijuana as a serious drug of abuse which, if set free, will destroy the fabric of our society. Others see it as one of God’s gifts to humankind and regularly call for its legalization for medical use. By 2018, the United Kingdom and 40 other countries had heeded that call. In the United States, medical marijuana has been approved in 30 states and the District of Columbia with more sure to follow. Going further, recreational use is allowed in 10 of those states. Nonetheless, marijuana possession continues to be illegal under federal law in the United States, and some physicians have been threatened with loss of their licenses for advocating medical marijuana. In 2015, combined state and federal laws led to more arrests for possession of small amounts of marijuana than those for all violent crimes combined. The word marijuana (or the alternate spelling marihuana) does not appear in American medical texts of the 19th century. Instead, the term cannabis referred to flowering tops of the female plant of Cannabis sativa. At that time, while millions of persons in Asia and Africa habitually indulged in cannabis as an intoxicant, cannabis was little used for that purpose in this country. In this chapter, I will use the term “cannabis” to refer to any active material derived from Cannabis sativa and Cannabis indica, the two species—some say subspecies—of the plant. Today’s controversies surrounding “medical marijuana” often ignore its long history in European and American medicine. Beginning in 1850, Cannabis indica and several extracts of the plant were listed in The United States Pharmacopeia, an official compilation of medically useful drugs.