bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations to Streamline and Standardize Clinical Trial Site Feasibility Assessments: An ASCO Research Statement
Authors: Kurbegov Dax , Hurley Patricia , Waterhouse David M. , Robert Nicholas J. , Nowakowski Grzegorz S. , Thompson Michael A. , Bruinooge Suanna S. , Schilsky Richard L. , Byatt Leslie , Dempsey Kandie , Dawson Casey , Hofacker Janie , Liu Jane , MacDougall A. Kate , Kim Edward S. 
Published: January 2021

PURPOSE: Feasibility assessments (FAs) are important to establish site capabilities to conduct clinical trials and their suitability for specific trials. However, current FA methods used by biotechnology and pharmaceutical (biotech-pharma) trial sponsors and contract research organizations (CROs) are costly, inefficient, unnecessarily burdensome, and resource intensive. These methods delay trial start-up, act as a barrier to site participation, and ultimately reduce timely patient access to clinical trials and novel treatments. METHODS: An ASCO Task Force was convened to assess the specific burdens and challenges with FAs and to develop recommendations to improve their efficiencies and effectiveness. Stakeholders (including trial sites, biotech-pharma sponsors, and CROs) provided insights into challenges and offered solutions through two surveys and an in-person meeting. The Task Force used the feedback to formulate consensus recommendations to improve FAs for oncology clinical trials. RESULTS: Three key recommendations were identified for application across all biotech-pharma sponsored trials: (1) implement a streamlined and uniform FA process across trials and sponsors; (2) minimize and standardize questions; and (3) leverage technology to centralize FAs, facilitate communications, and reduce redundancies. CONCLUSION: There is an urgency to improve the current FA process, which is costly, inconsistent, inefficient, labor intensive, and of uncertain effectiveness. All stakeholders stand to benefit from implementing these recommendations, which aim to minimize burdens and ensure that more trial sites and patients have timely access to oncology clinical trials. To have meaningful impact, adoption and consistent execution of these recommendations across all trials, sponsors, CROs, and sites are essential.
Age, neutrophil lymphocyte ratio, and radiographic assessment of the quantity of lung edema (RALE) score to predict in-hospital mortality in COVID-19 patients: a retrospective study
Authors: Sensusiati Anggraini Dwi , Amin Muhammad , Nasronudin Nasronudin , Rosyid Alfian Nur , Ramadhan Nanda Aulya , Lathifah Rofida , Puspitasari Eva , Wahyuningtyas Ria Indah , Soebakti Erika 
Published: January 2021

Background: Available data suggest that case fatality rate of COVID-19 patients in Surabaya is higher than global cases. Thus, it is important to identify risk factors to prevent the mortality. This study aimed to assess the factors associated with hospital mortality of COVID-19 patients, and develop a prediction score based on these findings. Methods: We analyzed 111 patients, who were diagnosed with COVID-19 based on reverse-transcriptase polymerase chain reaction. The following patient characteristics were obtained from records: age, gender, type of symptoms, onset of symptoms, neutrophil lymphocyte ratio (NLR), absolute lymphocyte count, chest x-ray abnormalities, lung involvement, type of lesion, radiographic assessment of the quantity of lung edema (RALE) score, and mortality. Data were analyzed using SPSS 25.0. Results Multivariate analysis showed that age >50 years (p=0.043), NLR score >5.8 (p=0.016) and RALE score >2 (p=0.002) can predict the mortality of COVID-19 patients in the hospital. ROC curve analysis of the score ability to predict mortality showed an area under the curve of 0.794. The cut-off point is 4.5, with a sensitivity of 96.7% and specificity of 49.4% to predict the mortality of COVID-19 patient in the hospital. Conclusions Age, NLR score and RALE score were associated with mortality of COVID-19 patients in the hospital and might be used as a predictor for mortality of COVID-19 patients in health care centre where radiologists are available. The prediction score may be useful for frontline physicians to effectively manage patients with a higher score to prevent mortality.
Exploring 12-Year trends in childhood obesity prevalence for the Republic of Ireland – a national study using survey data from 2002 and 2014
Authors: Millar Seán R. , Harding Mairead , McCarthy Laura E. , Kelleher Virginia , Harrington Janas M. , James Patrice , Whelton Helen , Perry Ivan J. 
Published: January 2021

Background: The prevalence of overweight and obesity among children may have reached a plateau in some developed countries, including Ireland. The aim of this study was to examine 12-year trends in the prevalence of overweight and obesity among primary-school-aged children in the Republic of Ireland between 2002 and 2014. Methods: Two large-scale oral health cross-sectional surveys of primary-school-aged children aged 4–13 years were conducted 12 years apart in 2002 (n=14,055; response rate=68%) and 2014 (n=5,223; response rate=67%). Both surveys included standardised and calibrated height and weight measures. Ownership of a means-tested medical card determined economic status. Standard International Obesity Task Force criteria were applied to determine the prevalence of overweight and obesity. Results: The overall prevalence of overweight/obesity among 4–13-year-olds significantly decreased from 26% (95% CI: 25.1%–26.5%) in 2002 to 24% (95% CI: 22.4%–24.7%) in 2014. Among boys and girls aged 4–13 years, the significant decrease was from 23% (95% CI: 22.1%–24.1%) to 20% (95% CI: 18.9%–22.0 and 28% (95% CI: 27.4%–29.5%) to 27% (95% CI: 25.0%–28.4%), respectively. Among 5-year-old children, the overall prevalence of overweight and obesity significantly decreased from 25% (95% CI: 23.7%–26.2%) to 22% (95% CI: 19.9%–23.4%). In 2002, the estimated prevalence of overweight/obesity was similar in children with and without medical cards, whereas in 2014, overall prevalence was higher in those with medical cards. Conclusions: Results suggest a fall in the prevalence of overweight/obesity between 2002 and 2014, and may suggest a favourable cohort effect. Despite this fall, the overall prevalence remains high and socioeconomic disparities have increased.
Clean air actions in China, PM2.5 exposure, and household medical expenditures: A quasi-experimental study
Authors: Xue Tao , Zhu Tong , Peng Wei , Guan Tianjia , Zhang Shiqiu , Zheng Yixuan , Geng Guannan , Zhang Qiang 
Published: January 2021

Background
Exposure to air pollution, a leading contributor to the global burden of disease, can cause economic losses. Driven by clean air policies, the air quality in China, one of the most polluted countries, has improved rapidly since 2013. This has enabled a unique, quasi-experiment to assess the economic impact of air pollution empirically.

Methods and findings
Using a series of nation-scale longitudinal surveys in 2011, 2013, and 2015, we first examined the questionnaire-based medical expenditure changes before and after the policy intervention for air pollution. Using a state-of-the-art estimator of the historical concentration of particulate matters with diameter less than 2.5 μm (particulate matter (PM)2.5), we further quantified the association between household medical expenditure and PM2.5 using mixed-effect models of the repeated measurements from 26,511 households in 126 cities. Regression models suggest a robust linear association between reduced PM2.5 and saved medical expenditures, since the association did not vary significantly across models with different covariate adjustments, subregions, or subpopulations. Each 10 μg/m3 reduction in PM2.5 was associated with a saving of 251.6 (95% CI: 30.8, 472.3; p-value = 0.026) Yuan in per capita annual medical expenditure. However, due to limitations in data quality (e.g., self-reported expenditures), and imperfect control for unmeasured confounders or impact from concurrent healthcare reform in China, the causality underlying our findings should be further confirmed or refuted.

Conclusion
In this study, we observed that compared with the PM2.5 reduction in 2013, the PM2.5 reduction in 2017 was associated with a saving of 552 (95% CI: 68, 1036) Yuan / (person × year), or approximately 736 billion Yuan (equivalent to 111 billion US dollar) per year nationally, which is equivalent to approximately 1% of the national gross domestic product of China.
Micro-incision vitrectomy surgery for primary rhegmatogenous retinal detachments with posterior vitreous detachments in elderly patients: Preoperative characteristics and surgical outcomes
Authors: Yamashita Kazuya , Sakakura Saki , Ofuji Yoshiko , Sato Maho , Nagamoto Takashi , Kubono Hirohisa , Kawamura Mari , Suzuki Kotaro 
Published: January 2021

Purpose
To assess the preoperative characteristics and surgical outcomes of using micro-incision vitrectomy surgery (MIVS) to treat RRD with posterior vitreous detachment (PVD) in an older and a younger patient group.

Methods
This retrospective cohort study included 407 eyes from 397 patients with primary RRD with PVD who were consecutively treated in our hospital from February 2016 to February 2020. PVD was diagnosed clinically by the presence of a Weiss ring, or was diagnosed morphologically via optical coherence tomography and subsequently confirmed during surgery. The main outcome measures were preoperative RRD characteristics, best-corrected visual acuity (BCVA), and postoperative complications.

Results
Data were analysed from 55 eyes in the elderly group (age 70 and older), and 352 eyes in the young group (age 69 and younger). There was no significant inter-group difference in the initial reattachment rate. Preoperative characteristics indicated that elderly patients had a significantly lower rate of phakic eyes, shorter mean axial length, lower lattice incidence, and longer time spans from onset to surgery. There were no significant between-group differences in the incidence of the following complications: fibrin formation, intraocular pressure elevation, epi-retinal membrane on the macula, intraocular lens optic capture, proliferative vitreoretinopathy, and vitreous haemorrhage. While the elderly patients had significant postoperative improvements in BCVA, these improvements were significantly lower than those of the younger patients.

Conclusions
This study highlighted the characteristics and surgical outcomes of MIVS in elderly patients with RRD. Although the time from onset to surgery was longer, MIVS still can be performed safely to improve older patients’ postoperative BCVA.
Pica, Autism, and Other Disabilities
Authors: Fields Victoria L. , Soke Gnakub N. , Reynolds Ann , Tian Lin H. , Wiggins Lisa , Maenner Matthew , DiGuiseppi Carolyn , Kral Tanja V.E. , Hightshoe Kristina , Schieve Laura A. 
Published: January 2021

BACKGROUND AND OBJECTIVES:
Pica, the repeated ingestion of nonfood items, can be life-threatening. Although case reports describe pica in children with autism spectrum disorder (ASD) or intellectual disability (ID), there has been little systematic study of pica prevalence. We assessed pica in children 30 to 68 months of age (median = 55.4 months) with and without ASD.

METHODS:
Our sample from the Study to Explore Early Development, a multisite case-control study, included children with ASD (n = 1426), children with other developmental disabilities (DDs) (n = 1735), and general population-based controls (POPs) (n = 1578). We subdivided the ASD group according to whether children had ID and the DD group according to whether they had ID and/or some ASD characteristics. Standardized developmental assessments and/or questionnaires were used to define final study groups, subgroups, and pica. We examined pica prevalence in each group and compared ASD and DD groups and subgroups to the POP group using prevalence ratios adjusted for sociodemographic factors.

RESULTS:
Compared with the prevalence of pica among POPs (3.5%), pica was higher in children with ASD (23.2%) and DD (8.4%), and in the following subgroups: ASD with ID (28.1%), ASD without ID (14.0%), DD with ID (9.7%), DD with ASD characteristics (12.0%), and DD with both ID and ASD characteristics (26.3%); however, pica prevalence was not elevated in children with DD with neither ID nor ASD characteristics (3.2%). Between-group differences remained after adjustment (adjusted prevalence ratio range 1.9–8.0, all P &lt;.05).

CONCLUSIONS:
Pica may be common in young children with ASD, ASD characteristics, and ID. These findings inform the specialized health care needs of these children.
A diencephalic circuit for opioid analgesia but not positive reinforcement
Authors: Waung Maggie , Maanum Kayla , Driscoll Joseph , O'Brien Chris , Bryant Svetlana , Mansourian Kasra , Morales Marisela , Barker David , Margolis Elyssa 
Published: January 2021

Abstract
Mu opioid receptor (MOR) agonists are the most effective analgesics, but their use risks respiratory depression and addiction. The epithalamic lateral habenula (LHb) is a critical site that signals aversive states, often via indirect inhibition of reward circuitry, and MORs are highly expressed in the LHb. We found that the LHb is a potent site for both MOR-agonist analgesia. Strikingly, LHb MOR activation generates negative reinforcement but is not rewarding in the absence of noxious input. While the LHb receives inputs from multiple sites, we found that inputs from the lateral preoptic area of the hypothalamus (LPO) are excited by noxious stimulation, express MOR mRNA, and are preferentially targeted by MOR selective agonists. Critically, optogenetic stimulation of LHb-projecting LPO neurons produces an aversive state relieved by LHb MOR activation. Therefore targeting this MOR sensitive forebrain circuit can relieve pain yet lower the risk of misuse by pain free individuals.
The influencing factors of the smoking behavior of online ride-hailing drivers in China: A cross-sectional analysis
Authors: Chen Xinlin , Gu Xuefei , Li Tingting , Xu Lirong , Liu Qiaoyan , Wu Nina 
Published: January 2021

Abstract
Background：Online ride-hailing is a fast-developing new travel mode, and tobacco control policies on it have not yet been improved. This study aims to reveal the smoking status and influencing factors of ride-hailing drivers, so as to provide a basis for the formulation of tobacco control policies.Methods：The cross-sectional data used in this study were derived from an online survey of full-time ride-hailing drivers in China. Questionnaires were employed to collect variables including sociodemographic and work-related characteristics, health status, health behavior, health literacy, and smoking status. Chi-Square test and multivariate logistic regression were used to analyze the influencing factors of current smoking.Results：A total of 8990 ride-hailing drivers were investigated, in which 5024 were current smokers, accounted to 55.9%. Current smokers (53.7% (2696/5024) v 44.2% (1752/3966); P<0.001) and drivers who smoked on the car (85.8% (1389/1618) v 38.4 (1307/3406); P<0.001) were more likely to allow passengers to smoke. Logistic regression analysis showed that men (OR=0.519, 95%CI (0.416, 0.647)), central regions (OR=1.172, 95%CI (1.049, 1.309)), eastern regions (OR=1.330, 95%CI (1.194, 1.480)), working at both daytime and night (OR=1.287, 95%CI (1.164, 1.424)), and working at non-fixed time (OR=0.847, 95%CI (0.718, 0.999)), 35-54 years old (OR=0.585, 95%CI (0.408, 0.829)), current drinker (OR=1.663, 95%CI (1.526, 1.813)), eating very irregularly (OR=1.370, 95%CI (1.233, 1.523)), the number of days a week of engaging in at least 10 minutes of moderate or vigorous exercise ≥ 3 (OR=0.752, 95%CI (0.646, 0.875)), taking the initiative to acquire health knowledge occasionally (OR=0.882, 95%CI (0.783, 0.992)) or frequently (OR=0.675, 95%CI (0.591, 0.770)) , underweight (OR=1.249, 95%CI (1.001, 1.559)) and overweight (OR=0.846, 95%CI (0.775, 0.924)) were associated with the prevalence of current smoking among online ride-hailing drivers (P<0.05). Conclusions：The smoking rate of ride-hailing drivers was high, and the social demographic and work-related characteristics, and health-related factors all affected their smoking behavior. Tobacco control measures targeted at online-hailing drivers should correct their cultural beliefs about smoking, increase their health literacy, guide them to exercise more and keep a regular schedule, as well as combine with drinking intervention and weight intervention.
Risk Transfer Policies Facilitate Smallholder Farmer Climate Adaptation
Authors: Choquette-Levy Nicolas , Wildemeersch Matthias , Oppenheimer Michael , Levin Simon 
Published: January 2021

Abstract
Increasing climate stress is likely to significantly impact smallholder farmer livelihoods, and can lead to divergent adaptation pathways. However, empirical evidence is inconclusive regarding how climate affects smallholder farmers’ deployment of various livelihood strategies, including rural-urban migration, especially as these impacts become more severe. Here we use an agent-based model to show that in a South Asian-type agricultural community experiencing a 1.5oC temperature increase by 2050, climate impacts are likely to decrease household income in 2050 by an average of 28 percent relative to the same income under a stationary climate, with fewer households engaging in economic migration and investing in cash crops. Pairing a small cash transfer with risk transfer mechanisms significantly increases the adoption of alternative livelihood strategies, improves community incomes, and reduces community inequality. While specific results depend on contextual factors such as risk preferences and climate risk exposure, these interventions are robust in improving adaptation outcomes by addressing the intersection of risk aversion, financial restrictions, and climate impacts.
Copy Number Variation in the CES1 Gene and the Risk of Non-Alcoholic Fatty Liver in a Chinese Han Population
Authors: Chen Bing bing , Yan Jian hui , Zheng Jing , Peng He wei , Cai Xiao ling , Pan Xin ting , Li Hui quan , Hong Qi zhu , Peng Xian-E 
Published: January 2021

Abstract
BackgroundA recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. We aimed to investigate whether CES1 CNVs was associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in a Chinese Han population.MethodsA case-control study was conducted among 303 patients diagnosed with NAFLD and 303 age (± 5) and sex-matched controls from the Affiliated Nanping First Hospital of Fujian Medical University in China. The copy numbers of CES1 were measured using TaqMan quantitative real-time polymerase chain reaction (qPCR) and serum CES1 was measured using enzyme-linked immunosorbent assays. The Chi-squared test and a logistic regression model were used to evaluate the association between CES1 CNVs and NAFLD susceptibility.ResultsThe distribution of CES1 CNVs showed a higher frequency of CNVs loss (< 2) among patients; however, the difference was not significant (P = 0.05). After controlling for other known or suspected risk factors for NAFLD, CES1 CNVs loss was significantly associated with greater risk of NAFLD (adjusted OR = 2.75, 95% CI: 1.30–5.85, P = 0.01); while CES1 CNVs gain (>2) was not. There was a suggestion of an association between increased CES1 serum protein levels and CNVs losses among cases, although this was not statistically significant (P=0.07).ConclusionsCopy number losses (< 2) of CES1 contribute to susceptibility to NAFLD in the Chinese Han population.
Confocal Laser Endomicroscopy Can Improve the Diagnosis Rate and Range Assessment of Patients With Conflicting Chronic Atrophic Gastritis Results of White Light Endoscopic and Pathological Diagnosis
Authors: Pang Suya , Shi Huiying , Yao Hailing , Jiang Chen , Zhang Qin , Lin Rong 
Published: January 2021

Abstract
Background: Chronic atrophic gastritis (CAG) are closely related to the development of gastric cancer. However, the diagnostic accuracy of white light endoscopy (WLE) biopsy for CAG is poor. The diagnostic role and efficacy of confocal laser microscopy (CLE) in CAG missed under WLE biopsy remains unclear.Methods: This study is a single-center prospective study that included 21 patients who were diagnosed with CAG under WLE, and whose pathological results were chronic inflammation. Then, all these patients received a CLE examination and endoscopic features were evaluated. All patients underwent targeted biopsies and five-point standard biopsies under CLE. The sensitivity, specificity, and accuracy of CLE diagnosis and targeted biopsy were analyzed by using the five-point standard biopsy pathological results.Results: The pathological results of five-point standard biopsies in 21 patients were CAG, and 17 patients (81.0%) were intestinal metaplasia (IM). According to the image diagnosis under CLE, 19 of these 21 patients (90.5%) were diagnosed with CAG, and 14 of them (66.7%) were diagnosed with IM. According to the targeted biopsy under CLE, 17 (81.0%) patients were diagnosed with CAG, and 14 of them (66.7%) were diagnosed with IM. There was no significant difference between CLE image diagnosis and five-point standard biopsies in terms of atrophy severity score (p=0.927), IM severity score (p=0.250), atrophy scope score (p=0.781) and IM scope score (p=0.195). For CAG, the sensitivity and accuracy of CLE image diagnosis were higher than those of CLE targeted biopsies (90.5% vs. 81.0%, p=0.331). For IM, the sensitivity, specificity and accuracy of CLE image diagnosis were the same as those of CLE targeted biopsies.Conclusions: CLE can improve the diagnosis rate of CAG, and can increase the comprehensive assessment of the scope and severity of CAG.