bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN BUKU SISWA BERTEMA CUACA MENGGUNAKAN METODE FOUR STEPS TEACHING MATERIAL DEVELOPMENT
Authors: Syar Nur Inayah , Meriza Nadya 
Published: December 2020

The teaching and learning process is built on three interaction aspects such as the interaction among the teachers, students, and learning sources. To ease this process, the teacher can make their own teaching material that will be used in learning process. This research aims to develop weather theme students’ book by using Four Steps Teaching Material Development (4STMD) method. The research method used was Research and Development (R&D). This students’ book consists of 5 sub-themes such as substance characteristics, interaction of organisms and their environment, temperature and heat, pollution and global warming. This book was developed by using 4STMD method through four stages such as selection, structurization, characterization, and didactic reduction. The feasibility test results show that the student book has complete material based on basic competencies and indicators, has accurate, actual and integrated material. Besides the student’s book that was developed also has aspects of legibility, language rules and language logic that is appropriate, presented attractively and has a layout and design that is feasible to be used. Overall the students’ perception on the usage and result of this students’ book development is positive. ABSTRAKProses belajar mengajar dibangun oleh tiga aspek interaksi. Interaksi tersebut adalah interaksi antara pendidik, peserta didik dan sumber belajar. Untuk memudahkan proses tersebut, guru dapat membuat sendiri bahan ajar (buku) yang akan digunakan dalam proses belajar mengajar. Penelitian ini bertujuan untuk mengembangkan buku siswa bertema Cuaca dengan metode Four Steps Teaching Material Development (4STMD) dan menganalisis kelayakan serta persepsi siswa terhadap buku siswa yang dihasilkan. Metode penelitian yang digunakan adalah Research and Development (R&D). Buku siswa ini terbagi atas 5 sub tema yaitu karakteristik zat, interaksi makhluk hidup dengan lingkungannya, suhu dan kalor, pencemaran dan pemanasan global. Buku ini dikembangkan dengan metode 4STMD melalui empat tahap, yaitu seleksi, strukturisasi, karakterisasi dan reduksi didaktik. Hasil Uji Kelayakan menggambarkan bahwa buku siswa memiliki cakupan materi yang lengkap berdasarkan Kompetensi Dasar dan indikator, memiliki materi akurat, mutakhir serta terpadu. Selain itu buku dikembangkan juga memiliki aspek keterbacaan, kaidah bahasa dan logika bahasa yang baik, disajikan dengan menarik dan memiliki tata letak serta desain yang layak digunakan. Adapun persepsi siswa terhadap penggunaan dan hasil pengembangan buku siswa, secara keseluruhan bernilai positif.
Method of drilling process control and experimental studies of resistance forces during bits drilling with PDC cutters
Authors: Neskromnykh Vyacheslav , Popova Marina , Golovchenko A. , PETENEV P. , Baochang Liu 
Published: December 2020

A rational, theoretically proved and empirically verified control system is a condition for optimal management of the drilling process in compliance with the criteria for minimizing the cost of time and material resources. A new generation of rock-cutting tools using PDC cutters (polycrystalline diamante cutters), which are extremely effective when drilling wells for various purposes in medium-hard rocks, dictates the need to develop methods and criteria for optimal control of the drilling process using this tool.
The paper presents an analysis of the force interaction between rock-cutting elements, face rock, and drilling mud saturated with slam, highlights the influencing factors and provides dependencies for determining the parameters of rock failure. Empirical verification of the theoretical propositions was carried out based on the data analysis from experimental bit drilling of marble with PDC cutters with a diameter of 76.2 mm, processed using the method of full factor experiment to obtain mathematical models of factors and their graphical interpretation.
The method of controlling the drilling process based on the optimal ratio of the tool rotation frequency, axial weight and deepening per one turnover is considered, which allows determining the rock failure mode at the well bottom by indirect signs and choose the optimal values of the drilling mode parameters that correspond to the most optimal conditions in terms of achieving the maximum mechanical drilling speed in conjunction with the rational mode of rock-cutting tool operation. A scheme is presented that contains possible variants of the bit run mode and ways to recognize them by the ratio of the deepening per turnover and the rotation frequency of the rock-cutting tool.
Numerical modeling of a double-walled spherical reservoir
Authors: Karavaichenko Mikhail , Gazaleev Linar 
Published: December 2020

Extensive and important class of multilayer shell structures is three-layer structures. In a three-layer structure, a rigid filler plays an important role, due to which the bearing layers are spaced that gives the layer stack high rigidity and durability with a relatively low weight. By combining the thicknesses of the bearing layers and the filler, the desired properties of a three-layer shell structure can be achieved. Compared with traditional single-walled, three-layer construction has increased rigidity and durability, which allows reducing the thickness and weight of the shells.
In order to reduce the metal content of the spherical reservoir for storing liquefied gases, this work considers the design of a double-walled reservoir, in which the inter-wall space is filled with reinforced polyurethane. Numerical modeling made it possible to determine the parameters of the stress-strain state of the structure with an error of no more than 5 %. It has been established on the example of a reservoir with a volume of 4000 m3 that the spatial structure of the spherical reservoir wall can reduce the metal content up to 19 %. Field of application for the research results is the assessment of the stress-strain state of spherical reservoirs at their designing.
Method for building the structure of a double-walled spherical reservoir in the SCAD software has been developed, which allows calculating the stress-strain state (SSS) by the finite element method.
Numerical model of a double-walled spherical reservoir has been developed. It was found that to obtain calculation results with an error of P ≤ 5 % the size of the final element should not exceed 300×300×δ mm.
Design of a double-walled spherical reservoir was investigated. Design parameters have been established to ensure the operational reliability of the structure with a decrease in metal content in comparison with a single-wall reservoir by 19 %.
Sistem Pendukung Keputusan Pemilihan Tentor Terbaik Dengan Metode Technique For Order Preference By Similarity To Ideal Solution (Topsis)
Authors: Situmorang Larisma , Sagala Jijon Raphita 
Published: December 2020

Abstrak— Tentor adalah Sumber daya manusia yang merupakan bagian yang sangat terpenting bagi tumbuh kembangnya sebuah Bimbingan Belajar. Bimbingan Belajar yang berkembang dengan baik sangatlah dipengaruhi oleh kualitas sumber daya manusia, yang dalam hal ini adalah tentor yang bekerja di dalam sebuah Bimbingan Belajar tersebut. Oleh karena itu, dilakukan pemilihan tentor terbaik menggunakan Metode sistem Keputusan Pemilihan Tentor Terbaik di Bimbingan Manna adalah Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). Sistem Pendukung Keputusan yang dibangun dapat membantu serta memudahkan pihak bimbingan belajar manna terutama ketua dalam mengambil sebuah keputusan pemilihan tentor terbaik yang dirancang dengan aplikasi berbasis website dan dengan database phpmyadmin. Form nilai matrik adalah form yang paling penting, karena didalam form ini dilakukan perhitungan dengan langkah-langkah perhitungan metode Topsis mulai dari awal, Nilai Matrik, Nilai Matrik Normalisasi, Nilai Bobot Normalisasi, Matrik Ideal Positif/Negatif, Jarak Solusi Ideal Positif/Negatif, Nilai Preferensi.
Effect of Tofu Dregs Flour Substitution and Tongkol Fish (Euthynnus affinis) on Patty Burger Quality
Authors: Daiyan Muhammad , Rahmiati Tengku Mia , Amin Amri 
Published: December 2020

Tongkol fish and tofu dregs have protein that can replace as a beef so that they can be used as a filling for burgers. This research used a completely randomized design (CRD) 2 factorial that used was the addition of cob fish = 150 grams, 200 grams and 250 grams and the addition of tofu dregs flour = 40 grams, 60 grams and 80 grams. The best treatment chosen for the results of this study was the quality burger patty with chemical properties of 78.95% water content, 3.38% ash content, content protein 16.54%, color organoleptic test 4.06 (likes), taste 4.00 (likes), texture 3.98 (likes), hedonic color test 4.13 (brownish red), aroma 4.18 (moderate) , texture 3.90 (soft) and unpleasant aroma 3.15 (moderate).
Barriers for people of color to RD in the US
Authors: White Jill 
Published: December 2020

The Healthy People 2010 objective of eliminating health disparities was prompted by the Institute of Medicine (IOM) report Unequal Treatment; Confronting Racial and Ethnic Disparities in Health Care . The report documented racial inequities within the U.S. health care delivery system, including differential treatment on the basis of race demonstrated by health care practitioners. Recommendation 5-3 was to Increase the proportion of underrepresented U.S. racial and ethnic minorities among health professionals .Between 2002 and 2008 the number of people of color entering undergraduate Nutrition programs increased by 67 %, while the number admitted to internships decreased by 11% . Of particular concern is the 58% decrease in African American's admitted into dietetic internships over the past decade. This paper is a discussion of barriers to RD that have been identified by African Americans in five studies, in hopes of shedding light on how to address and reverse this trend.
Pewarna Makanan dari Serangga (Cochineal) Menurut Perspektif Halal: Analisis Fatwa di Beberapa Negara ASEAN
Authors: Mohd Salleh Mohd Mahyeddin , Ahmad Nisar Mohammad , Ahmad Fadzillah Nurrulhidayah 
Published: December 2020

The colourants used in today’s food and beverage products are not only made from natural herbs or chemical substance, but also from animal-derived substance including insects. One of them is cochineal insect which produces red dye and it is largely consumed in the food and cosmetic industries. As such, the Muzakarah Jawatankuasa Fatwa Majlis Kebangsaan Bagi Hal Ehwal Ugama Islam Malaysia and Majelis Ulama Indonesia have issued a fatwa on the consumption of cochineal in food as permissible (halal). However, the Mufti Department of Brunei Darussalam has issued a fatwa to the contrary i.e. not permissible (haram). The existence of conflicting fatwas in halal and haram issues may cause confusions among Muslim consumers. This article aims to analyse fatwas on cochineal-based colourants in selected ASEAN countries namely Malaysia, Indonesia and Brunei. Document-analysis will be the method for this research. The research outcome indicates that there are factors that contribute to the differing fatwas i.e. differing understanding of the uncleanness status of insect carcasses whose blood does not flow, the use of different fatwa elicitation methodologies between countries, and the consideration on whether its use is good or bad for the consumers. Efforts towards standardisation of fatwa can be done at the ASEAN country levels via empowerment of halal supervisory body i.e. MABIMS, whose membership include Malaysia, Brunei, Indonesia and Singapore.
ABSTRAK
Bahan pewarna yang digunakan dalam produk makanan dan minuman masakini bukan hanya berasal dari bahan tumbuhan atau bahan kimia, tetapi juga diperolehi dari bahan haiwan, termasuk serangga. Salah satunya ialah serangga jenis cochineal yang menghasilkan warna merah pekat dan banyak dimanfaatkan oleh industri makanan dan kosmetik. Sehubungan itu, Muzakarah Jawatankuasa Fatwa Majlis Kebangsaan Bagi Hal Ehwal Ugama Islam Malaysia dan Majelis Ulama Indonesia telah mengeluarkan fatwa bahawa penggunaannya adalah halal. Sebaliknya, Jabatan Mufti Negara Brunei Darussalam memutuskan fatwa yang berlawanan iaitu haram. Kewujudan fatwa yang berbeza dalam aspek halal dan haram sudah pasti menimbulkan kekeliruan dalam kalangan pengguna Islam. Artikel ini bertujuan menganalisis fatwa-fatwa mengenai bahan pewarna cochineal di beberapa negara ASEAN terpilih iaitu Malaysia, Indonesia dan Brunei. Metodologi yang digunakan ialah analisis dokumen. Hasil kajian menunjukkan terdapat beberapa faktor yang membawa kepada perbezaan fatwa iaitu, i.e- kefahaman berbeza berhubung status kenajisan bangkai serangga yang darahnya tidak mengalir, penggunaan metodologi istinbat fatwa yang berbeza antara negara, dan pertimbangan maslahah dan mudarat kepada pengguna. Penyelarasan fatwa boleh digerakkan di peringkat negara ASEAN menerusi pemerkasaan badan halal yang dianggotai oleh empat negara iaitu Malaysia, Brunei, Indonesia dan Singapura (MABIMS).
Sexual health among adolescent and young adult cancer survivors: A scoping review from the Children's Oncology Group Adolescent and Young Adult Oncology Discipline Committee
Authors: Cherven Brooke , Sampson Amani , Bober Sharon L. , Bingen Kristin , Frederick Natasha , Freyer David R. , Quinn Gwendolyn P. 
Published: December 2020

AbstractSexual function is a vital aspect of quality of life among adolescent and young adult (AYA) (ages 15‐39 years) cancer survivors. Sexual function encompasses physical, psychosocial, and developmental factors that contribute to sexual health, all of which may be negatively impacted by cancer and treatment. However, limited information is available to inform the care of AYA cancer survivors in this regard. This scoping review, conducted by the Children's Oncology Group AYA Oncology Discipline Committee, summarizes available literature regarding sexual function among AYA cancer survivors, including relevant psychosexual aspects of romantic relationships and body image. Results suggest that, overall, AYA cancer survivors experience a substantial burden of sexual dysfunction. Both physical and psychosocial sequelae influence survivors' sexual health. Interventions to support sexual health and psychosexual adjustment after cancer treatment are needed. Collaborations between the Children's Oncology Group and adult‐focused cooperative groups within the National Cancer Institute's National Clinical Trials Network are warranted to advance prospective assessment of sexual dysfunction and test interventions to improve sexual health among AYA cancer survivors.
Effects of Cardiomyocyte-Specific Deletion of STAT3–A Murine Model of Heart Failure With Preserved Ejection Fraction
Authors: Zhao Weilin , Chen Yanjia , Yang Wenbo , Han Yanxin , Wang Zhiyan , Huang Fanyi , Qiu Zeping , Yang Ke , Jin Wei 
Published: December 2020

Aims: There is a high incidence of heart failure with preserved ejection fraction (HFpEF), but the options of treatment are limited. A new animal model of HFpEF is urgently needed for in-depth research on HFpEF. Signal transducer and activator of transcription 3 (STAT3) may affect the passive stiffness of myocardium, which determines cardiac diastolic function. We hypothesized that cardiomyocyte-specific deletion of STAT3 increases cardiac passive stiffness, which results the murine features of HFpEF.Methods and Results: Cardiomyocyte-specific deletion of STAT3 (STAT3cKO) mice was generated by the Cre/FLOXp method. The STAT3cKO mice showed heavier cardiac fibrosis and cardiac hypertrophy comparing with wild-type (WT) mice. Furthermore, STAT3cKO mice showed increased serum brain natriuretic peptide (BNP) level, and growth stimulation expressed gene 2 (ST2) level. Other indicators reflecting cardiac passive stiffness and diastolic function, including end diastolic pressure volume relation, MV A value, MV E value, E/A and E/E' had different fold changes. All these changes were accompanied by decreasing levels of protein kinase G (PKG). Bioinformatic analysis of STAT3cKO mice hearts suggested cGMP-PKG signaling pathway might participate in the pathogenesis of HFpEF by means of adjusting different biological functions.Conclusions: Cardiomyocyte-specific deletion of STAT3 results in a murine HFpEF model which imitates the clinical characteristics partly by affecting cardiac PKG levels. Better understanding of the factors influencing HFpEF may finally provided innovative therapies.
Image Descriptors for Weakly Annotated Histopathological Breast Cancer Data
Authors: Stanitsas Panagiotis , Cherian Anoop , Morellas Vassilios , Tejpaul Resha , Papanikolopoulos Nikolaos , Truskinovsky Alexander 
Published: December 2020

Introduction: Cancerous Tissue Recognition (CTR) methodologies are continuously integrating advancements at the forefront of machine learning and computer vision, providing a variety of inference schemes for histopathological data. Histopathological data, in most cases, come in the form of high-resolution images, and thus methodologies operating at the patch level are more computationally attractive. Such methodologies capitalize on pixel level annotations (tissue delineations) from expert pathologists, which are then used to derive labels at the patch level. In this work, we envision a digital connected health system that augments the capabilities of the clinicians by providing powerful feature descriptors that may describe malignant regions.Material and Methods: We start with a patch level descriptor, termed Covariance-Kernel Descriptor (CKD), capable of compactly describing tissue architectures associated with carcinomas. To leverage the recognition capability of the CKDs to larger slide regions, we resort to a multiple instance learning framework. In that direction, we derive the Weakly Annotated Image Descriptor (WAID) as the parameters of classifier decision boundaries in a Multiple Instance Learning framework. The WAID is computed on bags of patches corresponding to larger image regions for which binary labels (malignant vs. benign) are provided, thus obviating the necessity for tissue delineations.Results: The CKD was seen to outperform all the considered descriptors, reaching classification accuracy (ACC) of 92.83%. and area under the curve (AUC) of 0.98. The CKD captures higher order correlations between features and was shown to achieve superior performance against a large collection of computer vision features on a private breast cancer dataset. The WAID outperform all other descriptors on the Breast Cancer Histopathological database (BreakHis) where correctly classified malignant (CCM) instances reached 91.27 and 92.00% at the patient and image level, respectively, without resorting to a deep learning scheme achieves state-of-the-art performance.Discussion: Our proposed derivation of the CKD and WAID can help medical experts accomplish their work accurately and faster than the current state-of-the-art.
Six-Week Exercise Training With Dietary Restriction Improves Central Hemodynamics Associated With Altered Gut Microbiota in Adolescents With Obesity
Authors: Huang Junhao , Liao Jingwen , Fang Yang , Deng Hailin , Yin Honggang , Shen Bing , Hu Min 
Published: December 2020

PurposeObesity in children and in adolescents can lead to adult cardiovascular diseases, and the gut microbiota plays a crucial role in obesity pathophysiology. Exercise and diet interventions are typical approaches to improve physical condition and to alter the gut microbiota in individuals with obesity. However, whether central hemodynamic parameters including subendocardial viability ratio, the augmentation index standardized to a heart rate of 75/min (AIx75), resting heart rate, and blood pressure, correlate with gut microbiota changes associated with exercise and diet is unclear.MethodsAdolescents (n = 24, 12.88 ± 0.41 years) with obesity completed our 6-week program of endurance and strength exercises along with dietary restriction. Blood and fecal samples were collected, and physical parameters were measured before and 24 h after the last session of the intervention program. Pulse wave analysis using applanation tonometry provided the subendocardial viability ratio, a surrogate measure of microvascular myocardial perfusion, and AIx75, a measure of arterial stiffness and peripheral arteriolar resistance. Correlation analysis detected any associations of anthropometric or central hemodynamic parameters with gut microbiome composition.ResultsExercise and diet interventions significantly reduced body weight, body mass index, body fat, and waist-to-hip ratio, and lowered levels of fasting blood glucose, serum triglycerides, and high-density lipoprotein cholesterol. AIx75 and resting heart rate were also significantly reduced after the intervention without changes to systolic or diastolic blood pressure. The ratio of intestinal microbiota Firmicutes to Bacteroidetes displayed a marked increase after intervention. Interventional changes in gut microbiota members were significantly associated with anthropometric and metabolic parameters. Microbial changes were also significantly correlated with central hemodynamic parameters, including subendocardial viability ratio, AIx75, and resting heart rate.ConclusionExercise and diet interventions significantly improved measures of central hemodynamics, including subendocardial viability ratio, AIx75, and resting heart rate, which were correlated with altered gut microbiota in adolescents with obesity. Our findings shed light on the effects and mechanisms underlying exercise and diet interventions on obesity and suggest this approach for treating patients with both cardiovascular disease and obesity.
Glycemic Control Improvement in Italian Children and Adolescents With Type 1 Diabetes Followed Through Telemedicine During Lockdown Due to the COVID-19 Pandemic
Authors: Predieri Barbara , Leo Francesco , Candia Francesco , Lucaccioni Laura , Madeo Simona F. , Pugliese Marisa , Vivaccia Valentina , Bruzzi Patrizia , Iughetti Lorenzo 
Published: December 2020

Background/ObjectiveTo minimize the wide spread of coronavirus disease (COVID-19) pandemic, Italy was placed in an almost complete lockdown state that forced people to “stay at home”. Aim of this study was to evaluate the effects of lockdown on glycemic control in children and adolescents with type 1 diabetes (T1D) followed through telemedicine.Subjects/MethodsThis observational study involved patients with T1D using the real-time continuous glucose monitoring (CGM) Dexcom G6®. Ambulatory glucose profile data from the 3-months before schools closure (November 26, 2019–February 23, 2020; T0) and from the 3-months of consecutive lockdown (February 24–May 18, 2020; T1) were compared.ResultsSixty-two children and adolescents (11.1 ± 4.37 years, 50% males) with T1D (median time disease 3.67 years) were enrolled in the study. Insulin total daily dose was unchanged, while time spent on physical activities was decreased (p&lt;0.0001). Despite the lack of statistical significance, median value of the glucose management indicator decreased from 7.4% to 7.25%. Glucose standard deviation (p&lt;0.0001) and coefficient of variation (p=0.001) improved across the study. Median time in range increased from 60.5% to 63.5% (p=0.008), time above range decreased from 37.3% to 34.1% (p=0.048), and time below range decreased from 1.85% to 1.45% (p=0.001).ConclusionsOverall, in our children and adolescents with T1D glycemic control improved during lockdown. Despite patients were confined to their homes and limited to exercise, our data suggest that the use of real-time CGM, the continuous parental management, and the telemedicine can display beneficial effects on T1D care.