bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Canagliflozin on function of CD34+ endothelial progenitor cells (EPC) in patients with type 2 diabetes
Authors: Nandula Seshagiri Rao , Kundu Nabanita , Awal Hassan , Brichacek Beda , Fakhri Mona , Aimalla Nikhila , Elzarki Adrian , Amdur Richard , Sen Sabyasachi 
Published: November 2020

Abstract
Background: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been shown to be a robust cardiovascular disease (CVD) risk indicator. Effect of sodium glucose channel inhibitors (SGLT2 inhibitors) such as Canagliflozin (CG) on a cellular CVD risk indicator such as CD34+ve cells, in patients with T2DM with established CKD has not been explored,Methods: 29 subjects taking metformin and/or Insulin were enrolled in a 16 weeks, double blind, randomized placebo matched trial, with a low dose 100 mg CG compared to placebo. Type 2 diabetes subjects (30–70 years old), HbA1c of 7–10%,. CD34+ cell number, migratory function, gene expression along with vascular parameters such as arterial stiffness, biochemistry, resting energy expenditure and body composition were measured. Data were collected at week 0, 8 and 16. A mixed model regression analysis was done with p value less than 0.05 were considered significant.Results: Gene expression analysis of CD34+ve cells showed increase in antioxidants (superoxide dismutase 2 or SOD2, Catalase and Glutathione Peroxidase or GPX). A significant increase in gene expression of endothelial markers PECAM1 (p=0.002), VEGF-A(p= 0.04) and CXCR4 receptor (p= 0.06) followed by an increase in migratory function of CD34+ve cells is observed in Canagliflozin treated group as compared to placebo group. A significant reduction in glucose (p=0.01) levels was observed along with improved systolic and diastolic blood pressure in the CG group. Significant increase in adiponectin (p=0.02) was also noted in treatment group. Urinary exosomal protein examining podocyte health (podocalyxin, Wilm’s tumor and nephrin) showed improvement.Conclusion: We conclude that Canagliflozin on addition to metformin and/or Insulin, in subjects with type 2 diabetes demonstrates a functional improvement of CD34+ Endothelial Progenitor Cell function and gene expression and improves endothelial function
Development of an Immunochromatographic Strip for Rapid Detection of H7 Subtype Avian Influenza Viruses
Authors: Li Ge , Wang Xun , Li Qingmei , Yang Jifei , Liu Xiao , Qi Wenbao , Guo Junqing , Deng Ruiguang , Zhang Gaiping 
Published: November 2020

Abstract
Background: H7N9 avian influenza virus (AIV) including highly and low pathogenic viruses have been detected in China since 2013. H7N9 AIV has a high mortality rate after infection in humans, and most human cases have close contacted with poultry in the live poultry market. Therefore, it is necessary to develop a rapid point-of-care testing (POCT) technique for H7N9 AIV detection.Methods: The H7N9 AIV was inactivated and purified, and was used as the antigen to immunize BALB/c. Twelve H7-HA specific monoclonal antibodies (McAbs) were produced through the hybridoma technique. The McAb 10A8 was conjugated with colloid gold as detecting antibody; McAb 9B6 was dispensed on the nitrocellulose membran as the capture test line and the Goat-anti mouse IgG antibody was dispensed as control line respectively. The immunochromatographic strip was prepared.Results: The analysis of ELISA and virus neutralization test showed that the obtained McAbs specifically recognized H7 HA. Based on the prepared strip, the detection of H7 AIV was achieved within 10 min. No cross-reaction occurred between H7 AIVs and other tested viruses. The detection limit of the strip for H7 was 2.4 log10EID50/0.1 mL for chicken swab samples.Conclusion: The McAbs were specific for H7 and the immunochromatographic strip developed in this study was convenient, rapid and reliable for the detection of H7 AIV. The strip could provide an effective method for the rapid and early detection of H7 AIV.
Design and performance study of clutch disc assembly of wide-angle and large-hysteresis multi-stage damper
Authors: Xie Maoqing , Wang Leigang , Huang Yao 
Published: November 2020

Abstract
The clutch is an important component of the automobile driveline system, and its function is to ensure stable starting, smooth shifting and easy operation of the automobile. Judder and tremble are two kinds of common vibrations when a car starts, which seriously affect the driving and riding feelings of people in the car. Starting vibration and shaking are two kinds of common vibration in the beginning of a car, which seriously affect the driving and riding experience of people in the car. These two kinds of starting vibrations are closely related to the dry friction clutch in the driveline system, and the multi-stage torsional damper located on the clutch disc assembly plays an important role in the torsional characteristics of the vehicle driveline system. The stability of transmitted torque in automobile driveline system is directly affected by clutch torsional performance. In order to effectively eliminate torsional vibration and noise of driveline system excited by engine and improve driving comfort, this paper studies the structure and functional principle of wide-angle and large-hysteresis multistage damper disc assembly, and puts forward wide-angle and low-stiffness damping technology, large-hysteresis clutch technology, new split-type pre-damping structure technology, component protection buffer damping structure technology and multistage damping structure technology, and puts forward systematic solutions to effectively reduce driveline system vibration and noise.
Self-Powered All-Inorganic Perovskite Photodetectors with Fast Response Speed
Authors: Zhang Ting , Li Shibin 
Published: November 2020

Abstract
In this manuscript, the inorganic perovskite CsPbI2Br and CsPbIBr2 are investigated as photoactive materials that offers higher stability than the organometal trihalide perovskite materials. The fabrication methods allow anti-solvent processing the CsPbIxBr3−x films, overcoming the poor film quality that always occur in a single-step solution process. The introduced diethyl ether in spin-coating process is demonstrated to be successful, and the effects of the anti-solvent on film quality are studied. The devices fabricated using the methods achieve a high-performance, self-powered and stabilized photodetectors with fast response speed. The results illustrate a great potential of all-inorganic CsPbIxBr3−x perovskites in visible photodetection and provide an effective way to achieve high performance devices with self-powered capability.
Inequalities in healthcare utilisation: a decomposition analysis based on financial protection against health risks in Senegal
Authors: Samba Mouhamed , Thiam Ibrahima , Fecher Fabienne , Paul Elisabeth 
Published: November 2020

Abstract
Background: Developing countries are characterised by lack of financial protection against health hazards that can lead to health inequity. Improving horizontal equity in the utilisation of health care requires a better understanding of the factors that influence it. This study used Senegal as a case to examine healthcare utilisation disparities and their determinants. Methods: The study used the most recent Demographic and Health Survey (2017) from Senegal. Frequencies, a logit model and an extension of Blinder-Oaxaca decomposition (proposed by Fairlie) were employed to examine healthcare utilisation gap between covered and uncovered people as well as factors explaining this gap.Results: The results of the logistic regression show that healthcare utilisation increases with quintiles of economic well-being; people covered by an insurance or fee exemption scheme use more health care services than those not covered. Women, urban people, children aged under five years and elderly (60 and +). Results from Blinder-Oaxaca decomposition suggests a difference in healthcare utilisation between covered and uncovered people. 39% of these disparities are explained by the distribution of observed characteristics (age, area of residence, economic well-being, education) while 61% of these disparities are explained by differences in coefficients. This component may be related to discriminatory practices in favour of the persons covered.Conclusion: The results also raise the issue of the fragmentation of coverage schemes that can lead to differences in the care packages offered. Public authorities need to make efforts to reduce social inequalities and have an important stewardship role across all branches of society to ensure that policies and actions in other sectors improve health equity.
Relationship between Environment, Smoking Behavior, Education, Poverty, and Prevalence of Stunted Toddler in Indonesia: An Ecological Analysis
Authors: Laksono Agung Dwi , Wulandari Ratna Dwi 
Published: November 2020

Abstract
Background: The prevalence of stunted toddler in Indonesia is very high. The study was aimed at analyzing ecologically the factors related to the prevalence of stunted toddler in Indonesia.Methods: Ecological analysis was conducted using secondary data from the Ministry of Health of the Republic of Indonesia report in 2018. Apart from the stunted toddler, 6 other variables analyzed as independent variables were the percentage of households with access to safe drinking water sources, percentage of households with access to proper sanitation, percentage of households that occupy livable houses, percentage of the population who smoke, percentage of poor people, and percentage of the population completing basic education. Data were analyzed using a scatter plot.Results: The results of the study found that 4 variables (the percentage of household with access to a safe drinking water source, the percentage of household with access to proper sanitation, the percentage of the household that occupy livable houses, and the percentage of the population completing basic education) had a negative relationship with the prevalence of stunted toddlers in Indonesia. This means that the four variables are protective factors for a province to have a high prevalence of stunted toddler. Meanwhile, the percentage of poor people was found to be positively correlated with the prevalence of stunted toddlerConclusion: It was concluded that the five factors were related to the prevalence of stunted toddler in Indonesia.
Do descriptive norms messaging interventions backfire? Protocol for a systematic review of the boomerang effect
Authors: Kuang Jinyi , Delea Maryann G , Thulin Erik , Bicchieri Cristina 
Published: November 2020

Abstract
BackgroundDescriptive norms messaging interventions are used to motivate people to adopt or maintain desirable behaviors. Such interventions provide people with information that describes an undesirable behavior as uncommon or a desirable behavior as prevalent within a relevant social group. Descriptive norms messaging interventions have shown promise in increasing individual and social benefit for a broad range of health and sustainability programs. However, evidence suggests that people who have adopted desirable behaviors sometimes regress to undesirable behaviors after receiving descriptive norms messages due to the type of information provided in the messages. This phenomenon is called the boomerang effect. We aim to conduct a systematic review of boomerang effects on health and environmental sustainability behaviors resulting from exposure to descriptive norms messaging interventions.MethodsWe will employ our search strategy to identify studies of descriptive norms messaging interventions published prior to December 31, 2020. We will search Cochrane Library, Campbell Library, PsycINFO, PubMed, Social Science Research Network (SSRN), and Web of Science to retrieve peer-reviewed articles published in English. We will restrict inclusion to studies (e.g., randomized and non-randomized controlled trials, quasi-experimental studies, and observational studies) of health and environmental sustainability interventions that assess behaviors before and after exposure to descriptive norms messaging. Two reviewers will independently extract data about study populations and design, intervention components, and behavioral measures. We will use the revised Cochrane Risk of Bias assessment tool (RoB2) and Risk Of Bias in Non-randomized Studies – of Intervention (ROBIN-I) to assess the risk of bias, and the Liverpool Quality Assessment Tool (LQAT) to assess the quality of evidence. We will conduct thematic analyses to codify interventions, and examine intervention effects across subgroups of individuals based on their behavior prior to intervention exposure (e.g., those practicing desirable behaviors vs. undesirable behaviors). We will also conduct moderator analyses to determine whether boomerang effects are contingent upon other factors including intervention framing and delivery modality.DiscussionThis systematic review will provide information about descriptive norms messaging intervention effects across subgroups of individuals, and elucidate factors that potentially moderate boomerang effects. The review will yield evidence-based recommendations for the structure and content of descriptive norms messages that can be employed to avoid unintended boomerang effects within the context of health and sustainability programming.Systematic review registrationPROSPERO #: CRD42020156989
The impact of introducing ambulance and delivery fees in a rural hospital in Tanzania
Authors: Vossius Corinna , Md Estomih , Moshiro Robert , M Paschal , Kvaløy Jan Terje , Kidanto Hussein , Lyanga Sara , Ersdal Hege 
Published: November 2020

Abstract
Background:Access to health care facilities is a key requirement to enhance safety for mothers and newborns during labour and delivery. Haydom Lutheran Hospital (HLH) is a regional hospital in rural Tanzania with a catchment area of about two million inhabitants. Up to June 2013 ambulance transport and delivery at HLH were free of charge, while a user fee for both services was introduced from January 2014. We aimed to explore the impact of introducing user fees on the population of women giving birth at HLH in order to document potentially unwanted consequences in the period after introduction of fees.Methods:Retrospective analysis of data from a prospective observational study. Data was compared between the period before introduction of fees from February 2010 through June 2013 and the period after from January 2014 through January 2017. Logistic regression modelling was used to construct risk-adjusted variable-life adjusted display (VLAD) and cumulative sum (CUSUM) plots to monitor changes.Results:A total of 28,601 births were observed. The monthly number of births was reduced by 17.3% during the post-introduction period. Spontaneous vaginal deliveries were registered less frequently with a decrease of about 17/1000 births in non-cephalic presentations. Labour complications and caesarean sections increased with about 80/1000 births. There was a reduction in newborns with birth weight less than 2500 grams. The observed changes were stable over time. For most variables, a significant change could be detected after a few weeks.Conclusion:After the introduction of ambulance and delivery fees, an increase in labour complications and caesarean sections and newborns with low birthweight were observed. This might indicate that women delay the decision to seek skilled birth attendance or do not seek help at all, possibly due to financial reasons. Lower rates of births in a safe health care facility like HLH is of great concern, as access to skilled birth attendance is a key requirement in order to further reduce perinatal mortality. Therefore, free delivery care should be a high priority.
A More Practical Guide to Incorporating Health Equity Domains in Implementation Determinant Frameworks
Authors: Woodward Eva N , Singh Rajinder Sonia , Ndebele-Ngwenya Phiwinhlanhla , Castillo Andrea Melgar , Dickson Kelsey S. , Kirchner JoAnn E 
Published: November 2020

Abstract
Background: Due to striking disparities in implementation of healthcare innovations, it is imperative researchers and practitioners can meaningfully use implementation determinant frameworks to understand why disparities exist in access, receipt, use, quality, or outcomes of health care. Our prior work documented and piloted the first published adaptation of an existing implementation determinant framework with health equity domains to create the Health Equity Implementation Framework. We recommended integrating these three health equity domains to existing implementation determinant frameworks: 1) cultural factors of recipients, 2) clinical encounter, or patient-provider interaction, and 3) societal context (including but not limited to social determinants of health). This framework was developed for health care and clinical practice settings. Some implementation teams have begun using the Health Equity Implementation Framework in their evaluations and asked for more guidance.Methods: We completed a consensus process with our authorship team to clarify steps to incorporate a health equity lens into an implementation determinant framework.Results: We describe steps to integrate health equity domains into implementation determinant frameworks for implementation research and practice. For each step, we compiled examples or practical tools to assist implementation researchers and practitioners in applying those steps. For each domain, we compiled definitions with supporting literature, showcased an illustrative example, and suggested sample quantitative and qualitative measures.Conclusion: Incorporating health equity domains within implementation determinant frameworks may optimize the scientific yield and equity of implementation efforts by assessing and ideally, addressing, implementation and equity barriers simultaneously. These practical guidance and tools provided can assist implementation researchers and practitioners to concretely capture and understand barriers and facilitators to implementation disparities.
Knowledge, attitudes, practices, and the effects of COVID-19 on health seeking behaviors and social-economic status among young people in Kenya&nbsp;
Authors: Karijo Evalin , Wamugi Sylvia , Lemanyishoe Samuel , Njuki Jenny , Boit Faith , Kibui Vania , Karanja Sarah , Abuya Timothy 
Published: November 2020

Abstract
Background: Cases of the Corona Virus Disease of 2019 (COVID-19) in Kenya have continued to increase rapidly, since the first case in the country was confirmed in March 2020. In the wake of the pandemic, the health and socio-economic challenges experienced by the youth in Kenya are likely to be elevated. We assessed knowledge, practices, perceived risk, adoption of recommended behaviour and the effect of COVID-19 on health seeking behaviour related to sexual and reproductive health and social economic status among the youth.Methods: A cross sectional descriptive study was conducted between April 30th to May 7th, 2020 among 2,153 youth across all 47 counties in Kenya, through a combined online survey and phone interviews. All survey responses analyzed using STATA v15 were tabulated by gender, age, and education level to generate basic descriptive tables and tested for differences by category using chi-square tests. Where applicable, linear and logistic regression analysis model was conducted using covariates such as employment status, gender, and education level. Results: Knowledge on symptoms of COVID-19 was generally high. Female respondents were more likely to identify more symptoms correctly compared to men; p<0.001. However, youth reported very low levels of anyone being at risk of infection (7%). Most youth have adopted behavior necessary to slow down the infection. There were generally very low reported levels of inability to access health services related to sexual and reproductive health. About 50% of respondents reported significant decline in income during the pandemic period, nearly a third reported living in fear while 27% reported feeling stressed. Conclusion: There was high knowledge of COVID-19 symptoms, preventive strategies, and adoption of preventive practices. Despite the low reported inability to access health services related to sexual and reproductive health, response measures should include continuity of services. The reported adverse socioeconomic effects of the pandemic show the need for interventions to meet the health and socioeconomic needs of the youth and minimize the long term consequences of the pandemic. Strategies to sustain behaviors positively adopted among young people will be critical to reduce the spread of COVID-19.
Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway.
Authors: Huang Qianyi , Zhong Wei , Yi Xia , Qin Zhen , Tang Xiangqi 
Published: November 2020

Abstract
Background: Rosiglitazone (RSG) is a widely used antidiabetic drug which activates peroxisome proliferator-activated receptor-γ. Recent work have shown that RSG can up-regulate caveolin-1 levels and ameliorate both chronic and acute brain injury. However, whether rosiglitazone can ameliorate ischemic injury in the brain via a caveolin-1-dependent pathway remains unknown.Methods: Adult male sprague-dawley rats were randomly divided into sham operation group, model group, rosiglitazone group and rosiglitazone+daidzein group. The rat models of middle cerebral artery occlusion (MCAO) was established using the suture method, with ischemia for 2 hours and reperfusion for 22 hours. Neurological deficits were evaluated by the methods of Longa’s standard scoring. Cerebral infarction volume was observed by staining with 2, 3, 5-triphenyltetrazolium chloride. Evans blue content reflects BBB permeability. The expressions of caveolin-1, matrix metalloproteinase-9(MMP-9) and occludin were detected by immunofluorescent staining and western blot.Results: In this study, we found that the expression of caveolin-1 was increased in a rat model of stroke, and treatment with RSG significantly increased the levels of caveolin-1, reduced the release of MMP-9, and increased the expression of occludin. On the other hand, a caveolin-1 inhibitor daidzein canceled the protective roles of RSG in the MCAO model.Conclusions: These data unveil that RSG might protect blood-brain barrier integrity by down-regulating the levels of MMP-9 via a caveolin-1-dependent pathway.