bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Safety of Anagrelide Hydrochloride versus Hydroxyurea in Essential Thrombocythaemia
Authors: Gotic Mirjana , Egyed Miklos , Gercheva Liana , Warzocha Krzysztof , Kvasnicka Hans Michael , Achenbach Heinrich , Wu Jingyang 
Published: October 2020

AbstractEssential thrombocythaemia (ET) is a rare myeloproliferative neoplasm. This multicentre, Phase 3b, randomised, open-label, non-inferiority study investigated the cardiac safety, efficacy and tolerability of first-line treatment with anagrelide or hydroxyurea in high-risk ET patients for up to 3 years. Eligible patients aged ≥ 18 years with a diagnosis of high-risk ET confirmed by bone marrow biopsy within 6 months of randomisation received anagrelide (n = 75) or hydroxyurea (n = 74), administered twice daily. Treatment dose for either compound was titrated to the lowest dose needed to achieve a response. Planned primary outcome measures were change in left ventricular ejection fraction from baseline over time and platelet count at Month 6. Planned secondary outcome measures were platelet count change from baseline at Months 3 and 36; percentage of patients with complete or partial response; time to complete or partial response; number of patients with thrombohaemorrhagic events; and changes in white blood cell count or red blood cell count over time. Neither treatment altered cardiac function. There were no significant differences in adverse events between treatment groups, and no reports of malignant transformation. The incidence of disease-related thrombotic or haemorrhagic events was numerically higher in anagrelide-treated patients. Both treatments controlled platelet counts at 6 months, with the majority of patients experiencing complete or partial responses. In conclusion, these results suggest that long-term treatment with anagrelide is not associated with adverse effects on cardiac function. This is one of the few studies using left ventricular ejection fraction assessment and central biopsy reading to confirm the diagnosis of ET.Trial registration number: Clinicaltrials.gov NCT00202644
Mindful Age and Technology: a Qualitative Analysis of a Tablet/Smartphone App Intervention Designed for Older Adults
Authors: Vailati Riboni Francesco , Sadowski Isabel , Comazzi Benedetta , Pagnini Francesco 
Published: October 2020

AbstractThe global population is aging while modern healthcare systems are responding with limited success to the growing care demands of the senior population. Capitalizing on recent technological advancements, new ways to improve older adults’ quality of life have recently been implemented. The current study investigated, from a qualitative point of view, the utility of a mindfulness-based smartphone application for older adults. A description of the older adults’ experience with the smartphone application designed to enhance well-being and mindfulness will be presented. Participants’general beliefs about the benefits of technology for personal well-being will also be discussed. 68 older adults were recruited from different education centers for seniors. Participants were randomly assigned to two groups: a) a treatment group, which received the smartphone application intervention (n = 34), or b) a waitlist control group (n = 34). The experimental intervention included the utilization of a smartphone app designed specifically for improving older adult well-being and mindfulness levels. Participants completed semi-structured interviews evaluating participants’ treatment experience and technology-acceptance at recruitment (T0, baseline) and post-intervention (T1, post-intervention). Through thematic analysis, four themes were identified from verbatim responses of both interviews: Utility of technology for health, Impressions of technology, Mindful-benefits of smartphone application usage, and Smartphone application usage as a means to improve interpersonal relationships. Participants showed a positive experience of the app intervention. Qualitative analysis underlined the main Mindfulness-benefits reported by participants and the potentially crucial role of “Langerian” mindfulness in the relationship between older adults and health technology.
Do people choose happiness? Anticipated happiness affects both intuitive and deliberative decision-making
Authors: Kumalasari Asteria D. , Karremans Johan C. , Dijksterhuis Ap 
Published: October 2020

AbstractPeople make choices among different options for different reasons. We hypothesized that people will choose the options that they believe will make them happier and that this effect of anticipated happiness on decision-making will be moderated by style of thinking (i.e., intuitive or deliberative). In a two-phase online experiment, 15 pairs of options were randomly presented one at a time, and participants indicated the extent to which each option would contribute to their happiness (i.e. anticipated happiness of a choice option). One week later, participants were randomly assigned to make choices on similar pairs of options either by using deliberative thinking or intuitive thinking. Results of a linear mixed-effects model analysis revealed that anticipated happiness influenced choices significantly. However, this occurred independent of whether participants made the choice in a deliberative or in an intuitive mindset. The implications of these findings for understanding the association between decision-making and happiness are discussed.
Comparing the extent of breast cancer tumors through contrast-enhanced ultrasound vs B-mode, opposed with pathology: evergreen study
Authors: Shima Hiroaki , Okuno Toshitaka , Nakamura Takashi , Noro Aya , Noma Midori , Sato Megumi , Kaga Terumi , Mituzuka Yukio , Kamei Keitaro , Imayoshi Yumi , Ito Toshikazu , Kanazawa Shinsaku , Kato Kumiko , Kutomi Goro , Sekiguchi Ryuzo , Mori Mitsuru , Tadashi Hasegawa , Hirai Toshiko , Takemasa Ichiro 
Published: October 2020

Abstract
Background
To prove the efficacy of contrast-enhanced ultrasound (CEUS) in determining the extent of resection, more evidence about B-mode and CEUS as opposed to pathology is required. We compared maximum tumor width measured on B-mode/CEUS images with that determined pathologically.

Methods
In this retrospective multicenter study, 152 operable breast cancer patients who had undergone both B-mode and CEUS were analyzed. Maximum tumor width on B-mode and CEUS, and on the postoperative pathological examination (P), was measured by the participating investigators. In addition, maximum width was assessed in B-mode and CEUS image sets by independent reviewers blinded to all patient information. We analyzed differences in maximum width between CEUS, B-mode and P.

Results
The mean widths as measured by the participating investigators were 15 ± 7 mm (B-mode), 19 ± 8 mm (CEUS), and 17 ± 9 mm (P). The difference subtracted P from B-mode was − 3 ± 7 mm (p < 0.0001), and that from CEUS was 1 ± 6 mm (p = 0.0163). The mean widths as measured by the independent reviewers were 16 ± 7 mm (B-mode) and 18 ± 7 mm (CEUS). The difference subtracted P from B-mode was − 2 ± 8 mm (p = 0.0114), while that from CEUS was 1 ± 7 mm (p = 0.1921).

Conclusions
Maximum lesion width measurement showed a tendency to increase in the order of B-mode, to P and CEUS. The difference in measurement between P and B-mode was significant, but there was no significant between CEUS and P. These results provide additional information of tendency patterns in measuring the maximum lesion width through enhancement on CEUS.
Pancreatic solid pseudopapillary neoplasm in male patients: systematic review with three new cases
Authors: Milanetto Anna Caterina , Gais Zürcher Anna-Lea , Macchi Lorenzo , David Alina , Pasquali Claudio 
Published: October 2020

AbstractPancreatic solid pseudopapillary neoplasm (pSPN) is a rare exocrine neoplasm, which generally occurs in young women. This study analyses the clinical characteristics of pSPN in male patients through a systematic review of the literature, adding three new cases from our institution. We reviewed our experience in Pspns, and we performed a systematic review of pSPN of all articles published in English in PubMed and SCOPUS from 1980. Using the final included articles, we evaluated clinic-pathological features, surgical treatment and prognosis of male patients affected by pSPN. From the literature review and our cases, we collected 246 male patients with a proven pSPN. Mean age was 34.3 (range 4–78) years, with 26.2% patients younger than 18 years. Patients were asymptomatic in 35.9% of cases, despite a mean tumour size of 6.3 cm. In 63.7% of cases, the pSPN was located in the body–tail region. Distant metastases were reported at diagnosis in only 10 (4.1%) patients. A correct pre-operative diagnosis (including cytopathology) was provided in 53.6% of patients, with only 40 fine-needle aspiration/biopsy performed. Standard pancreatic resections represented 90.4% of surgical procedures. Beta-catenin and progesterone receptors were positive at immunostaining in 100% and 77.8% of cases, respectively. Fourteen (7.2%) patients relapsed after a mean disease-free survival of 43.1 months. After a mean follow-up of 47 (range 4–180) months, 89.5% of patients were alive and disease-free. Although rare, when dealing with a solid-cystic pancreatic mass, even in asymptomatic male patients, a pSPN should be considered as a possible diagnosis.
Barriers to Autism Spectrum Disorder Diagnosis for Young Women and Girls: a Systematic Review
Authors: Lockwood Estrin Georgia , Milner Victoria , Spain Debbie , Happé Francesca , Colvert Emma 
Published: October 2020

AbstractThere is increased recognition that women and girls with autism spectrum disorders (ASD) are underserved by the clinical criteria and processes required to receive a diagnosis. This mixed-methods systematic review aimed to identify key barriers to obtaining an ASD diagnosis in girls and young women under 21 years. Six themes were identified that focused on perceived gendered symptoms, namely behavioural problems, social and communication abilities, language, relationships, additional diagnoses/difficulties and restricted and repetitive behaviours and interests. Five themes were identified as (parental) perceived barriers to diagnosis, namely compensatory behaviours, parental concerns, others’ perceptions, lack of information/resources and clinician bias. This review highlights the importance of enhancing widespread understanding and recognition of ASD presentation in females across development. PROSPERO Centre for Reviews and Dissemination (ID 2018 CRD42018087235)
Designing for the co-Orchestration of Social Transitions between Individual, Small-Group and Whole-Class Learning in the Classroom
Authors: Olsen Jennifer K. , Rummel Nikol , Aleven Vincent 
Published: October 2020

AbstractEducational technologies are often developed such that students work on specific social levels (e.g., individual, small group, whole class) at specific times. However, in the reality of the classroom, learning activities are not so cleanly divided, with transitions occurring between social levels for students at different times. To support these social transitions in a way that can promote student learning, we need to lower the teacher’s orchestration load around managing fluid social transitions. Co-orchestration, in which the orchestration decisions are shared between different parties, can help to lower the orchestration load when it is designed according to the teacher’s values and classroom culture. In this paper, we present a taxonomy of social transitions and investigate how the responsibilities of orchestration can be divided between primary school teachers and a co-orchestration system in order to support the extension from rigid social transitions to fluid transitions in technology-enhanced classrooms. Across two studies, we used a design process involving co-design and prototyping with teachers. We uncovered and refined co-orchestration design desires that balance teachers’ orchestration loads while providing them with a sense of control. We present six design desires for maintaining a balance between teacher and system responsibilities regarding the orchestration of social transitions that can be implemented, such as in our mid-fidelity prototype, to support the range of social transitions. The list of desires contributes to co-orchestration research and more broadly technology design for classrooms by highlighting the changing balance of teacher control depending on what is the focus of the orchestration support.
Diagnostic accuracy of anti-phospholipase A2 receptor (PLA2R) antibodies in idiopathic membranous nephropathy: an Italian experience
Authors: Porcelli Brunetta , Guarnieri Andrea , Ferretti Fabio , Garosi Guido , Terzuoli Lucia , Cinci Francesca , Tabucchi Antonella , Tampoia Marilina , Abbracciavento Letizia , Villani Chiara , Deleonardi Gaia , Grondona Ana Gabriela , Mazzolini Marcello , La Manna Gaetano , Santostefano Marisa , Infantino Maria , Manfredi Mariangela , Spatoliatore Giuseppe , Rosati Alberto , Somma Chiara , Bizzaro Nicola 
Published: October 2020

Abstract
Background
Autoantibodies against-phospholipase A2 receptor (PLA2R) are specific markers of idiopathic membranous nephropathy (iMN). Enzyme-linked immunosorbent assay (ELISA) is becoming the preferred method in many laboratories for the determination of anti-PLA2R antibodies, because it provides quantitative results, and is not prone to subjective interpretation, as is the case with indirect immunofluorescence assay.

Methods
The purpose of our study was to determine the diagnostic performance of serum PLA2R antibodies detected by commercially available ELISA in a large Italian multicenter cohort of patients with biopsy-proven iMN and in patients with other renal diseases, with special focus on evaluating the optimal cut-off value to discriminate positive and negative results. A total of 495 consecutive patients were recruited. Renal biopsies were performed in all patients, and blood samples were taken before the initiation of immunosuppressive treatment.

Results
According to the clinical diagnosis and to kidney biopsy, 126 patients were diagnosed with iMN and 369 had other non-membranous nephropathies. Anti-PLA2R autoantibodies were detected using a commercial anti-PLA2R ELISA. At a cut-off value of 20 relative units (RU)/ml indicated by the manufacturer for positive classification, sensitivity was 61.1% and specificity 99.7%. At a cut-off value of 14 RU/ml indicated by the manufacturer for borderline results, sensitivity was 63.5% and specificity remained the same (99.7%). At a cut-off of 2.7 RU/ml, selected as the optimal cut-off on the basis of ROC curve analysis, sensitivity was 83.3% and specificity 95.1%. The best overall efficiency of the test was observed at 2.7 RU/ml; however, the highest positive likelihood ratio and diagnostic odds ratio were achieved at 14 RU/ml. A cut-off threshold higher than 14 RU/ml or lower than 2.7 RU/ml entailed worse test performance.

Conclusion
Depending on the clinical use (early diagnosis or as a support to confirm clinical diagnosis), nephrologists may take advantage of this evidence by choosing the most convenient cut-off. However, renal biopsy remains mandatory for the definitive diagnosis of iMN and for the assessment of disease severity.
A strongly irreducible affine iterated function system with two invariant measures of maximal dimension
Authors: MORRIS IAN D. , SERT CAGRI 
Published: October 2020

AbstractA classical theorem of Hutchinson asserts that if an iterated function system acts on

$\mathbb {R}^{d}$
by similitudes and satisfies the open set condition then it admits a unique self-similar measure with Hausdorff dimension equal to the dimension of the attractor. In the class of measures on the attractor, which arise as the projections of shift-invariant measures on the coding space, this self-similar measure is the unique measure of maximal dimension. In the context of affine iterated function systems it is known that there may be multiple shift-invariant measures of maximal dimension if the linear parts of the affinities share a common invariant subspace, or more generally if they preserve a finite union of proper subspaces of

$\mathbb {R}^{d}$
. In this paper we give an example where multiple invariant measures of maximal dimension exist even though the linear parts of the affinities do not preserve a finite union of proper subspaces.
Generation of polarized particle beams at relativistic laser intensities
Authors: Büscher Markus , Hützen Anna , Ji Liangliang , Lehrach Andreas 
Published: October 2020

AbstractThe acceleration of polarized electrons, positrons, protons and ions in strong laser and plasma fields is a very attractive option for obtaining polarized beams in the multi-mega-electron volt range. Recently, there has been substantial progress in the understanding of the dominant mechanisms leading to high degrees of polarization, in the numerical modeling of these processes and in their experimental implementation. This review paper presents an overview on the current state of the field, and on the concepts of polarized laser–plasma accelerators and of beam polarimetry.
INFINITE STRINGS AND THEIR LARGE SCALE PROPERTIES
Authors: KHOUSSAINOV BAKH , TAKISAKA TORU 
Published: October 2020

AbstractThe aim of this paper is to shed light on our understanding of large scale properties of infinite strings. We say that one string
$\alpha $
has weaker large scale geometry than that of
$\beta $
if there is color preserving bi-Lipschitz map from
$\alpha $
into
$\beta $
with small distortion. This definition allows us to define a partially ordered set of large scale geometries on the classes of all infinite strings. This partial order compares large scale geometries of infinite strings. As such, it presents an algebraic tool for classification of global patterns. We study properties of this partial order. We prove, for instance, that this partial order has a greatest element and also possess infinite chains and antichains. We also investigate the sets of large scale geometries of strings accepted by finite state machines such as Büchi automata. We provide an algorithm that describes large scale geometries of strings accepted by Büchi automata. This connects the work with the complexity theory. We also prove that the quasi-isometry problem is a
$\Sigma _2^0$
-complete set, thus providing a bridge with computability theory. Finally, we build algebraic structures that are invariants of large scale geometries. We invoke asymptotic cones, a key concept in geometric group theory, defined via model-theoretic notion of ultra-product. Partly, we study asymptotic cones of algorithmically random strings, thus connecting the topic with algorithmic randomness.
What kind of home is your care home? A typology of personalised care provided in residential and nursing homes
Authors: Ettelt Stefanie , Williams Lorraine , Damant Jacqueline , Perkins Margaret , Wittenberg Raphael 
Published: October 2020

AbstractThis paper examines how care home managers in England conceptualised the approach to delivering personalised care in the homes they managed. We conducted interviews with care home managers and mapped the approaches they described on two distinct characterisations of personalised care prominent in the research and practitioner literature: the importance of close care relationships and the degree of resident choice and decision-making promoted by the care home. We derived three ‘types’ of personalised care in care homes. These conceptualise the care home as an ‘institution’, a ‘family’ and a ‘hotel’. We have added a fourth type, the ‘co-operative’, to propose a type that merges proximate care relationships with an emphasis on resident choice and decision-making. We conclude that each approach involves trade-offs and that the ‘family’ model may be more suitable for people with advanced dementia, given its emphasis on relationships. While the presence of a range of diverse approaches to personalising care in a care home market may be desirable as a matter of choice, access to care homes in England is likely to be constrained by availability and cost.
Medically unexplained symptoms in children: an experimental investigation of the impact of internet searching on parental responses
Authors: Hughes Tyler , Meredith Francesca , Monteregge Sabrina , Bennett Sophie D. , Shafran Roz 
Published: October 2020

AbstractBackground:Medically unexplained symptoms (MUS) are symptoms for which no medical cause can be identified. For children and adolescents, symptoms can be maintained through parental responses.Aims:The present study investigated the impact that internet searching of symptoms has on parental responses to MUS.Method:One hundred and twenty-seven adult participants read a vignette in which they were asked to imagine they were a parent of a young person with MUS and completed visual analogue scales (VAS) reporting their beliefs, emotions and behavioural intentions about the MUS. Participants were then randomly assigned to one of three conditions: searching reputable websites for further information about the symptoms (n = 47), free search of any websites for further information about the symptoms (n = 38) or a control condition (n = 42) during which participants spent 10 minutes doing their usual behaviour on the internet, for example checking email and social media. Participants then completed the VAS for a second time.Results:Searching reputable websites led to a significantly greater decrease in behaviour VAS scores compared with the free search condition [F (1,123) = 11.374, p < .001], indicating that participants were less likely to seek a second opinion and to advise the child to avoid usual activities.Conclusions:This study demonstrated that internet searching reputable sites for information regarding physical symptoms can be positive and it may therefore be advisable for health professionals meeting children with MUS to provide the family with information links to reputable sources.
Designing a healthy, low-cost and environmentally sustainable food basket: an optimisation study
Authors: Eini-Zinab Hassan , Sobhani Seyyed Reza , Rezazadeh Arezoo 
Published: October 2020

AbstractObjective:Sustainable diets are diets with low environmental impacts and high affordability which contribute to food and nutrition security. The present study aimed to develop a healthy, low-cost and environmental-friendly food basket for Iran based on current consumption.Design:The Households Income and Expenditure Survey data were used. Linear Programming was utilised to obtain the optimal diets, separately, for each goal of the sustainable food basket: (1) Diet with maximum Nutrient Rich Food (NRF) index, (2) Diet with minimum cost, (3) Diet with the minimum water footprint and (4) Diet with the minimum carbon footprint. Goal Programming techniques were used to optimise the sustainable food basket by considering all goals simultaneously.Setting:Iran.Participants:Households (n 100 500) in urban and rural areas of Iran, nationally representative.Results:In the ‘optimal model’, compared with the usual consumption, the amount of the ‘bread, cereal, rice, and pasta’, ‘meat, poultry, fish, eggs, legumes, and nuts’ and ‘fats, oils, sugars, and sweets’ groups was decreased. Inside those food groups, cereals, poultry and vegetable oil subgroups were increased. Also, dairy, fruits and vegetable groups were increased. In this model, there was a 14 % reduction in the total water footprint, a 14 % decrease in the total carbon footprint, a 23 % decrease in the cost and a 7 % increase in NRF of diet compared with the usual consumption.Conclusions:Increasing the consumption of dairy, fruits and vegetables and reducing the consumption of bread, rice, pasta, meat, fish, eggs, legumes, nuts, hydrogenated fats and sugars are required to achieve a sustainable food basket.