bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI PEMANFAATAN MOBILE MARKETING BERBASIS ANDROID MENGGUNAKAN METODE BUYER BLACK BOX PADA PERUSAHAAN RETAIL DI JAKARTA
Authors: Novita Diana , Sari Yunita 
Published: July 2020

Abstract : This article illustrates preparation of your paper using MS-WORD. Papers should not be numbered. The manuscript should be written in English. The length of manuscript should not exceed 12 pages in this format using A4 single-sided papers. The title page should include the succinct title, the authors, and an abstract of around 200 words at the beginning of the manuscript. The affiliation, address and zip code, and telephone and fax numbers as well as e-mail address should be listed below each author's name. The paper begins with a title which uses 14pt Times New Roman. This is followed by the details for each author in 10pt Times New Roman. Section titles are bolded in 11pt Times New Roman. The remainder of the paper should be typed in 10pt Times New Roman. If you have any question on the format, please send a message to simetris@umk.ac.id
Abstrak : Meningkatnya penggunaan smartphone di dunia menyebabkan mobile marketing menjadi salah satu cara pemasaran yang sangat dipertimbangkan. Indonesia merupakan salah satu negara dengan jumlah pengguna mobile device yang cukup besar. Hal ini berakibat semakin sering nya akses terhadap konten mobile yang akhirnya potensi lebih luas untuk berinovasi dalam mobile marketing. Berdasarkan kondisi tersebut, kami sangat tertarik untuk mengadakan penelitian dengan tema mobile marketing dengan maksud dan tujuan jangka panjang kami adalah diharapkan dapat menambah wawasan keilmuan kami didalam bidang pemasaran secara digital atau biasa disebut dengan e-commerce. Sedangkan target khusus kami adalah membantu para pelaku bisnis agar dapat dengan mudah memahami dan menggunakan mobile marketing didalam strategi pemasaran mereka. Didalam penelitian ini kami akan menggunakan metode black box dengan alat bantu berupa kuisioner dan wawancara. Tujuan dari penggunaan kuisioner dan wawancara ini untuk mensurvei para pengguna smartphone dan juga para pelaku bisnis agar kami bisa mengetahui apakah mobile marketing yang telah digunakan dalam bisnis memberikan kontribusi pendapatan yang bedr bagi perusahaan. Kemudian kami memberikan batasan kesuksesan dari hasil kuisioner tersebut. Sehingga kami mendapatkan hasil evaluasi yang bisa digunakan sebagai bahan perbandingan dan pembelajaran bagi para pelaku bisnis khususnya dan bagi kami pada umumnya.
PENILAIAN KETAHANAN KELUARGA TERHADAP KELUARGA GENERASI MILLENIAL DI ERA GLOBALISASI SEBAGAI SALAH SATU PONDASI KETAHANAN NASIONAL
Authors: Amalia Luthfi 
Published: July 2020

Abstract: Today's family character is well known as millennial family because the family social environment in globalization era tends to use technology as supporting tools for daily activities such as using internet-connected smartphones to communicate between family members with social media (WhatsApp, Line, Instagram, Facebook, etc.) and to access the latest information available from all parts of the world. Patterns of family life that change because of the ease of accessing information in the use of technology raises the challenges of life that increasingly heavily in family life. Therefore, a family needs to maintain the value and function of family which become indicator of resilience of a family. Because family resilience will describe the quality of personality and behavior patterns of family members in interacting and socializing with the community. The indicators of family resilience based on family values and functions are divided into three categories: physical resilience, social resilience and psychological resilience. Based on the results of the research, family resilience of millenial generation is considered quite strong because it is in the range of 67% between 88.5%. This is because millennial family generation is still running the value and family functions that become indicators of family resilience in order to create harmony and resilience in the family.
Abstrak: Karakter keluarga saat ini lebih dikenal dengan keluarga generasi millennial karena lingkungan sosial keluarga di era globalisasi saat ini, cenderung menggunakan teknologi sebagai alat penunjang kegiatan sehari-hari seperti menggunakan smartphone yang terkoneksi dengan internet untuk berkomunikasi antar anggota keluarga dengan media social (WhatsApp, Line, Instagram, Facebook, dll) dan untuk mengakses informasi terbaru yang ada dari seluruh belahan dunia. Pola kehidupan keluarga yang berubah karena adanya kemudahan mengakses informasi dalam penggunaan teknologi menimbulkan tantangan hidup yang semakin berat dalam kehidupan berkeluarga. Oleh karena itu suatu keluarga perlu mempertahankan nilai dan fungsi keluarga yang menjadi indicator ketahanan suatu keluarga. Karena ketahan keluarga akan menggambarkan kualitas kepribadian dan pola perilaku anggota keluarga dalam berinteraksi dan bersosialisasi dengan masyarakat. Indikator ketahanan keluarga berdasarkan nilai dan fungsi keluarga dibedakan menjadi tiga kategori yaitu ketahanan fisik, ketahanan social dan ketahanan psikologis. Berdasarkan hasil penelitian ketahanan keluarga generasi millenial dinilai cukup kuat karena berada pada kisaran 67% antara 88.5%. Hal tersebut dikarenakan keluarga generasi millennial masih menjalankan nilai dan fungsi keluarga yang menjadi indicator ketahanan keluarga agar dapat tercipta keharmonisan dan ketahanan dalam keluarga.
HERMENEUTIKA AMINA WADUD SEBAGAI BASIS TAFSIR HARMONI ADIL GENDER DI INDONESIA
Authors: Said Nur 
Published: July 2020

<p>The domination of the interpretation of the Koran that tends to gender bias has been continued until now. Therefore the presence of Wadud as a feminist thinker to be interesting discussed. This article is to track the social and intellectual background that affect her points of views in term of tafsir and its relevance for developing feminist tafsir in Indonesia. This paper used the philosophical and hermeneutical approach. The data were collected by the method of documentation and discussed with the content analysis. The conclusions among others that Wadud has given a contribution in breaking down the traditional interpretation of the Koran by offering a critical approach to interpret the Koran based on the awareness of tauhid and analyse the preor-text in the interpretive process. This model of tafsir can be developed in Indonesian tafsir that still be dominated by male commentators, therefore in a certain level still become gender biased. It can be reproduced becoming an alternative feminist tafsir to build harmony sociaty in Indonesia.</p>
Utilizing Principles of Private Enterprise to Improve Maternal and Child Health Programs
Authors: Rotheram-Borus Mary Jane , Tomlinson Mark 
Published: July 2020

High quality maternal and child health (MCH) programs are needed to meet the global Sustainable Development Goals 1, 2, 3, and 10. Yet, the vast majority of MCH programs are small, lack capacity and personnel, and are judged based on their relationships with funders, rather than their performance in the field. Adopting principles common among private enterprise could have a significant impact on shifting MCH to focus on implementing larger, higher quality programs and to routinely evaluate MCH as meeting/ not meeting their primary mission. For example, focusing on recruiting personnel who have excellent social skills and are pragmatic problem-solvers reflects a principle of Hire the Best Staff. Similar principles such as Leadership Matters and Create a Culture of Discipline are guideposts that can improve the quality of MCH programs over time. This commentary outlines criteria which could both guide MCH organizational development and funders’ evaluations of MCH.
Key words: • Leadership • Private Sector • Maternal And Child Health Programs • Global Health • Developing Countries

Copyright © 2020 Rotheram-Borus and Tomlinson. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Cognitive Impairments and Associated Factors After Ruptured Anterior Communicating Artery Aneurysm Treatment in Low-Grade Patients &lt;60 Years: A Multicenter Retrospective Study
Authors: Ma Ning , Feng Xin , Wu Zhongxue , Wang Daming , Liu Aihua 
Published: July 2020

Abstract
Background Aneurysmal subarachnoid hemorrhage (SAH) is a kind of destructive cerebrovascular disease which could affect people's cognition, even the life expectancy. People with SAH are considered in a fatal situation, especially in the young population. This study aimed to investigate cognitive impairment and related factors in young patients with ruptured anterior communicating artery (ACoA) aneurysms.Methods We conducted a multicentre retrospective follow-up study at three hospitals in China. The young patients (18-50 years) who underwent ruptured ACoA aneurysm treatment by microsurgical clipping or endovascular coiling at three academic institutions in China from January 2015 to November 2017 were recruited. Patient cognition and life quality were assessed by using modified Telephone Interview for Cognitive Status (TICS-m), the modified Rankin Scale (mRS), and the instrumental activities of daily living (IADL) scale 2. Multiple cox-regression analysis was used to identify variables independently associated with cognitive impairment.Results Of the total of 59 patients, 54 (91.5%) achieved good clinical outcomes (mRS score 0-2) and 51 (86.4%) had excellent quality of life (IADL score 8). Ten (16.9%) patients showed cognitive impairments (TICS-m<27). The multivariate COX regression analysis showed that mRS scores of 3-5 at discharge, female sex, and aneurysm size <5 mm was independently associated with cognitive impairment. TICS-m scores at the latest follow-up were similar after open surgery and coiling. Conclusion In this relatively young sample that excluded patients with very poor-grade SAH or serious complications, microsurgical clipping led to better clinical outcomes than endovascular coiling, while cognitive outcomes were similar across treatment modalities. These results are not completely consistent with previous studies, and should therefore be considered in the clinical practice as well as further investigated in larger patient samples.
Adverse effects of nicotine on endometrium receptivity markers: and protective effect of caffeic acid phenyl ester
Authors: NAMDARI AMIN , MOHAMMADIAN FARIDEH , KHAJEH Fatemeh , KAVOUSIPOUR SOUDABEH , miladpour behnoosh 
Published: July 2020

Abstract
Background

nicotine adversely affects the female reproductive system and changes the methylation pattern of some genes in the placenta. In contrast, caffeic acid phenylethyl ester) CAPE (, as a potent antioxidant, has protective effects against the harmful effects of oxygen free radical molecules, methotrexate, and pesticides on the reproductive system. To find the effect of nicotine on the endometrium, we investigated three markers of endometrium receptivity including fibroblast growth factor 2, vascular endothelial growth factors A, and C-X-C motif chemokine ligand 12 and also changes in methylation levels of CXCL-12 gene promoter. In addition, we evaluated the protective effect of CAPE against nicotine.
Methods

the appropriate treatment dose was selected based on the literature, the endometrial stromal cells were divided into 4 groups, including control, treated with nicotine, CAPE, and nicotine followed by CAPE. Finally, the quantitative polymerase chain reaction and Methylation-Specific PCR were carried out.
Results

The results showed that treatment of endometrial stromal cells with nicotine (10− 6 µM) for 24 h significantly reduced expression of CXCL-12, FGF, and VEGFA genes. However, a decrease in CXCL-12 expression was not associated with increased methylation levels in the studied promoter region. In contrast, endometrial stromal cells treated with CAPE (4 µg/ml) for 24 h adverse significantly nicotine-induced reduction of CXCL-12, FGF, and VEGFA genes expression.
Conclusion

Exposure to nicotine has negative effects on uterine receptivity, implantation, and fertility, via reducing the expression of VEGFA, CXCL-12, and FGF2 genes. In contrast, CAPE has a protective effects and improves these genes expression.
Pregnancy Outcomes of Patients with Takayasu’s Arteritis -- A Retrospective Clinical Analysis
Authors: Liu Simiao , Liu Juntao , Gao Jinsong , Yingna Song 
Published: July 2020

Abstract
Background: Takayasu’s arteritis (TA) often occurs in women of reproductive age and affect gestational outcomes. However, TA is a rare disease, and the number of reports addressing the effect of TA on pregnancy in Chinese women is small. We aimed to analyse the influence of TA on gestational outcomes and explore related factors.Methods: We studied the medical records of 28 pregnancies among 27 women with TA. Patient characteristics, TA activity and classification, treatment, laboratory test results, delivery mode, obstetrical complications, medical complications during pregnancy and pregnancy outcomes were evaluated and compared.Results: The mean age of all patients at delivery was 30.28±4.54 years. The live birth rate was 96.4%, and the gestational age at delivery was 36.5±2.78 weeks. Gestational complications included preeclampsia (22.2%), foetal distress (14.8%), intrauterine growth restriction (22.2%) and premature delivery (37.0%). Medical complications during pregnancy included heart failure (11.1%), pulmonary hypertension (3.7%), and Sjogren syndrome (3.7%). The TA status in ten pregnancies was active, and compared with those of pregnancies with inactive TA, the rates of obstetrical complications and medical complications were higher (P=0.014 and P=0.047, respectively). The rate of seeking standard treatment and follow-up was lower among patients with active disease (P=0.021). Among all patients, the Kerr scores and severity scores during pregnancy were similar to those before pregnancy (P=0.664 and P=0.134, respectively).Conclusions: Active TA may increase the risk of pregnancy complications and medical complications. When treated in a timely and appropriate manner, the gestational outcome is good.
Amlexanox Enhances Temozolomide-Induced Anti-Tumor Effects In Human Glioblastoma Cells By Inhibiting Ikbke And The Akt-mtor Signaling Pathway
Authors: Xiong Jinbiao , Guo Gaochao , Guo Lianmei , Wang Zengguang , Chen Zhijuan , Nan Yang , Cao Yiyao , Li Ruilong , Yang Xuejun , Dong Jun , Jin Xun , Yang Weidong , Huang Qiang 
Published: July 2020

Abstract
Background: Temozolomide (TMZ), as the first-line chemotherapeutic agent for the treatment of glioblastoma multiforme (GBM), often fails to improve the prognosis of GBM patients due to the quick development of resistance. The need for more effective management of GBM is urgent. The aim of this study is to evaluate the efficacy of combined therapy with TMZ and amlexanox, a selective inhibitor of inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE), for GBM.Methods: in vitro, cell viability assay, apoptosis analysis, western blot, migration and invasion assay were used. In vivo, intracranial tumor models were constructed and the immunohistochemistry were used. Results: We found that combined treatment resulted in significant induction of cellular apoptosis and the inhibition of cell viability, migration and invasion in primary glioma cell and in the human glioma cell line, U87 MG. TMZ enhanced expression of phosphoration of adenosine 5‘-monophosphate-activated protein kinase (p-AMPK) and amlexanox led to reduction of IKBKE, with no impact on p-AMPK. Furthermore, we demonstrated that, compared to other groups treated with each component alone, TMZ combined with amlexanox effectively inhibited phosphorylation of protein kinase B (AKT) and mammalian target of rapamycin (mTOR). In addition, the combination treatment also clearly reduced in vivo tumor volume and prolonged median survival time in the xenograft mouse model. Conclusion: These results suggest that amlexanox sensitized primary glioma cell and U87 MG cell to TMZ at least partially though the suppression of IKBKE activation and the attenuation of AKT activation. Overall, combined treatment with TMZ and amlexanox may provide a promising possibility for improving the prognosis of glioblastoma patients in clinical practice.
miR-129-5p Inhibits Clear Cell Renal Cell Carcinoma Cell Proliferation, Migration and Invasion by Targeting SPN
Authors: Gao Bin , Wang Lijuan , Zhang Yubo , Zhang Na , Han Miaomiao , Liu Huancai , Sun Dongli , Wu Xiaotang , Xiao Xiaolong , Liu Yifei 
Published: July 2020

Abstract
Objective: Our study aims to investigate the mechanism of the miR-129-5p/SPN axis in clear cell renal cell carcinoma (ccRCC), providing a novel direction for the targeted therapy of ccRCC. Methods: Bioinformatics methods were implemented to find the differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed to detect miR-129-5p and SPN mRNA expression, while western bot was carried out for the detection of protein expression of SPN. Bioinformatics analysis was used to predict the binding sites of miR-129-5p on SPN 3’UTR, while dual-luciferase assay was conducted to verify their binding relationship. CCK-8 assay, colony formation assay, wound healing assay and Transwell assay were employed to measure ccRCC cell proliferative ability, cell formation ability, cell migratory and invasive abilities.Results: miR-129-5p exhibited a significantly down-regulated expression level in ccRCC, while SPN showed a remarkably up-regulated expression level. Overexpressed miR-129-5p inhibited ccRCC cell proliferative, invasive and migratory capacities. Dual-luciferase assay confirmed that there was a binding relationship between miR-129-5p and SPN. Additionally, overexpressing miR-129-5p markedly reduced SPN expression in tumor cells, and attenuated the promoting effect of SPN on cell proliferation, migration and invasion.Conclusion: Our study proves the regulatory effect of the miR-129-5p/SPN axis in ccRCC, and provides a novel potential target for precise treatment of patients with ccRCC.
Association between Sense of Loneliness, Social support, Quality of Life and Multimorbidity in Elderly Patients
Authors: Vespa Anna , Spatuzzi Roberta , Gattafoni Pisana , Fabbietti Paolo , Giulietti Maria Velia 
Published: July 2020

Abstract
Multi-morbidity has been associated with adverse health outcomes, such as reduced physical function, poor quality-of-life(QoL), poor self-rated health. The adverse impact of multi-morbidity on other health domains is further exacerbated by other factors. In this study the association between quality of life, social support, sense of loneliness and sex, age in elderly patients affected by two or more chronic diseases (multi- morbidity) was evaluated. Patients n. 216 affected by tumors hypertension, cardiovascolar diseases, ictus, diabetes, all self-sufficient and living with family members. Tests: MMSE-Mini-Mental-State-Examination; ADL-Activities of Daily Living; Social-Schedule: demographic variables; Loneliness Scale -de Jong Gierveld; Quality-of-Life - FACT-G; WHOQOL-BRIEF social relationships. Statistical analysis: Multivariate Regression Analysis. The patients with three or more diseases have worse dimensions of QoL Physical-well-being(p = .003), Social well-being (p = .003), Emotional-well-being(p = .012), Functional-well-being(p < .001), than those with two. Multiple linear regression. QoL: PWB, SWB, EWB,FWB as dependent variables.In the presence of multi-morbidity with an increase in the patient's age PWB (B = − .131, p = .014), SWB (B = − .170, p = .009) EWB (B = − .457, p < .000), FWB (B=-.139,p = .013), decreases by an average of 0.1, and as the sense of solitude increases PWB (B=-.425, p < .000), SWB(B=-.464,p < .000),EWB(B=-.457,p < .000),FWB(B=-468,p < .000) decrease by 0.4. The sense of loneliness and increasing age are associated with bad quality-of life in self-sufficient elderly patients with multi-morbidity. Demonstrating that loneliness, also in presence of interpersonal relations, predicted worse quality of life helps identify people most at risk for common symptoms and lays the groundwork for research about diagnosis and treatment.
Optimization of Energy Consumption and Analysis of the Emission of Greenhouse Gases in the Production of Rice (Case Study of Mazandaran Province)”
Authors: Vahedi adel , yousefi zahra 
Published: July 2020

Abstract
The present study has been done with the aim of investigating the energy consumption pattern, the economic analysis of production and assessing the greenhouse gas emissions (GHG) resulting from the production of rice in the Mazandaran province. The input and output energies were calculated and energy indices were determined. The efficiency of the rice farms and the optimization of energy consumption were estimated by using Data Envelopment Analysis (DEA) method and the amount of greenhouse gas emissions was determined after improving the consumption of inputs. According to the results, the total energies of consumed inputs and outputs for the production of paddy were calculated to be 91,061.5 and 100,967.95 MJ ha-1, respectively. The energy input of diesel fuel, machinery and chemical fertilizers were determined to be 41.27%, 19.63% and 19.58% out of the total energy inputs, representing the most highly consumed energy inputs in the production of paddy.
Prevalence of malnutrition in COVID-19 inpatients: the Nutricov study
Authors: Rouget Antoine , Vardon-Bounes Fanny , Lorber Pierre , Vavasseur Adrien , Marion Olivier , Marcheix Bertrand , Lairez Olivier , Balardy Laurent , Fourcade Olivier , Conil Jean-Marie , Minville Vincent 
Published: July 2020

Abstract
Background: Recent ESPEN guidelines highlighted the interest of prevention, diagnosis and treatment of malnutrition in the management of coronavirus disease 19 (COVID-19) patients. The aim of our study was to evaluate the prevalence of malnutrition in patients hospitalized for COVID-19. Methods: Prospective observational cohort study on COVID-19 inpatients admitted to a tertiary hospital. Malnutrition was diagnosed according to the Global Leadership Initiative on Malnutrition two-step approach. Patients were divided in two groups according to the diagnosis of malnutrition. Covariate selection for the multivariate analysis was based on P value <0.2 in univariate analysis, with a logistic regression model and a backward elimination procedure. A partitioning of the population was represented using a Classification and Regression Tree analysis.Results: 80 patients were prospectively enrolled in the study. Thirty patients (37.5%) had criteria for malnutrition. The need for ICU admission (n=46, 57.5%) was similar in the two groups. Three patients who died (3.75%) were malnourished. Multivariate analysis exhibited that low BMI (OR=0.83, 95% CI [0.73-0.96], p=0.0083), dyslipidemia (OR=29.45, 95% CI [3.12-277.73], p=0.0031), oral intakes reduction <50% (OR=3.169, 95% CI [1.04-9.64], p=0.0422) and GFR (CKD-EPI) at admission (OR=0.979, 95% CI [0.96-0.998], p=0.0297) were associated with the occurrence of malnutrition in COVID-19 inpatients.Conclusions: We demonstrate the existence of a high prevalence of malnutrition (37.5%) in a general cohort of COVID-19 inpatients according to GLIM criteria. Considering this high prevalence, nutritional support in COVID-19 care seems an essential element. Trial registration: Ethical Committee No 2020-A01237-32)(RC31/20/0165 NUTRI-COV