bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory effects of acute milk consumption among asthmatic and non-asthmatic children: a randomized controlled study
Authors: Koren Yael , Armoni Domany Keren , Gut Guy , Hadanny Amir , Benor Shira , Tavor Oren , Sivan Yakov 
Published: September 2020

Abstract
Background
A commonly held public belief is that cow’s milk products increase mucus production and respiratory symptoms. Dietary milk elimination is often attempted despite lack of evidence. Our objective was to investigate whether a single exposure to cow’s milk is associated with respiratory symptoms and changes in pulmonary functions in asthmatic and non-asthmatic children.

Methods
We conducted a prospective double blind, placebo-controlled trial on non-asthmatic and asthmatic children aged 6–18 years evaluated at a pediatric pulmonology unit.
The children were randomly challenged with cow’s milk or soy milk substitute. Symptoms, spirometry, fractional-exhaled nitric-oxide (FeNO), and pulse oximetry findings were obtained at baseline and at 30, 60, 90, and 120 min following challenge.
A two-way ANCOVA (with repeated measures when required) was used to compare the performances of all groups and subgroups over time. The outcome measures of each participant were compared to his/her own variables over time and in relation to his/her baseline values. In case of missing data points, missingness analysis was performed using Little’s missing completely at random (MCAR) test.

Results
Fifty non-asthmatic children (26 assigned to the cow’s milk group and 24 to the soy substitute group), and 46 asthmatic children (22 in the cow’s milk group and 24 in the soy substitute group) were enrolled. Age, gender, and body mass index Z-score were comparable between the two groups. No changes in symptoms, spirometry, FeNO, or oxygen saturation measurements were observed following challenge in any of the participants in both groups, at any time point compared to baseline.

Conclusions
A single exposure to cow’s milk is not associated with symptoms, bronchial inflammation, or bronchial constriction in both non-asthmatic and asthmatic children. Our findings do not support the strict elimination of dairy products from a child’s diet for the prevention of respiratory symptoms.

Trial registration
This study was approved by the Tel Aviv Sourasky Medical Center Institutional Review Board and the Israeli Ministry of Health review board (Helsinki Committee, NIH #NCT02745899). Registered April 2016 https://clinicaltrials.gov/ct2/show/NCT02745899?cond=milk+asthma&rank=1.
A rare case report of laryngopharyngeal polyp formation following anterior cervical discectomy and fusion (ACDF)
Authors: Li Xiucheng , He Lei , He Wei , Lv Zuo , Chen Xuerong 
Published: September 2020

Abstract
Background
Anterior Cervical Discectomy and Fusion (ACDF) has been regarded as the “gold standard” treatment of cervical spondylosis. Though it has good outcomes, many complications still exist, such as loss of fixation, degeneration of adjacent segments, dysphagia and pharyngeal perforation. In view of current literature, this study is the first to report a case of laryngopharyngeal polyp following ACDF.

Case presentation
A 63 year old male patient suffered from cervical spine hyperextension after trauma accompanied by numbness of the hands and decreased muscle strength in both upper limbs. Anterior cervical fusion surgery was performed in our hospital, after which the patient’s upper limb numbness disappeared and muscle strength returned to normal. In the fifth month after surgery, the patient developed a sore throat and dysphagia. Symptoms gradually worsened, and the patient was hospitalized four times, subsequently undergoing tracheotomy, internal fixation removal, and polypectomy. The patient’s pronunciation, breathing, and swallowing functions returned to normal, and the incision healed. After a one-year follow-up, the polyp did not recur.

Conclusions
Laryngopharyngeal polyp formation following ACDF has yet to be reported in literature. By excluding esophageal fistula as soon as possible, removing internal fixation and polypectomy serves as the best treatment in relieving patient symptoms.
Use of symptom-focused oncological cancer therapies in hospices: a retrospective analysis
Authors: Kaiser Ulrich , Vehling-Kaiser Ursula , Kück Fabian , Mechie Nicolae-Catalin , Hoffmann Ana , Kaiser Florian 
Published: September 2020

Abstract
Background
There is controversy regarding the practical implementation of symptom-focused oncological cancer therapies to hospice residents. In this study, we aim to analyse the use and indication of supportive-oncological cancer therapies in hospices.

Methods
We conducted a retrospective survey of all residents of two hospice centres in the government district of Lower Bavaria, Germany. Hospice 1 (H1) was a member of an oncological–palliative medical network, and hospice 2 (H2) was independently organized. The evaluation period was the first 40 months after the opening of the respective hospice care centre. Demographical and epidemiological data as well as indications and type of supportive-oncological cancer therapies were recorded. A descriptive analysis and statistical tests were performed.

Results
Of the 706 residents, 645 had an underlying malignant disease. The average age was 72 years and the mean residence time was 28 days. The most frequent cancer types were gastrointestinal cancers, gynaecological cancers and bronchial carcinomas. Overall 39 residents (33 in H1 and 6 in H2, p < 0.01) received symptom-focused oncological cancer therapy. The average age of these residents was 68 years, and the mean residence time was 55 days. The most common therapeutic indications were dyspnoea and pain. The most common symptom-focused oncological cancer therapies were bisphosphonates, transfusions (erythrocyte- and platelet- concentrates), radiotherapy and anti-proliferative drugs (chemotherapy, anti-hormonal- and targeted- therapies). Patients with therapy lived significantly longer than patients without therapy (p < 0.01).

Conclusions
Symptom-focused oncological cancer therapies can be implemented in hospices; however, their implementation seems to require certain structural and organizational prerequisites as well as careful patient selection. As a palliative medical approach, the focus is to ameliorate the symptoms and not prolong life. Symptom-focused oncology treatment could be a further and important part for the therapy of hospice patients in the future.
New acute respiratory management in tracheal rupture caused by chest trauma
Authors: Shen Cheng , Ma Lin 
Published: September 2020

AbstractWe report a case who is a 33-year-old man admitted to our Emergency room for chest trauma caused by the factory’s mechanical arm. Despite the endotracheal tube, the patient’s respiratory state was poor and the oxygen saturation did not improve and the subcutaneous emphysema progressed. To improve distressed breathing, we first proposed the concept “mechanical ventilation with dual ventilator” to maintain oxygen saturation of the patient. This is, to our knowledge, the first report of using a special mechanical ventilation method in emergency surgery.
Isolated fallopian tube torsion associated with hydrosalpinx in a 12-year-old girl: a case report
Authors: Martín-Vallejo Javier , Garrigós-Llabata Enrique E. , Molina-Bellido Patricia , Clemente-Pérez Pedro A. 
Published: September 2020

Abstract
Background
Isolated fallopian tube torsion associated with hydrosalpinx is a rare condition in the pediatric population. We present this unusual clinical case study in a sexually inactive girl.

Case presentation
a12-year-old Caucasian girl presented symptoms of acute abdominal pain. Pelvic ultrasound revealed a normal looking uterus and ovaries and next to left ovary a imaging compatible with hydrosalpinx. She was discharged 48 hours later after clinical monitoring with oral analgesia and normal blood workup. At 3 weeks, she was readmitted for acute abdominal pain. Leukocytosis with left shift and raised C-reactive protein were observed. Her clinical condition worsened, and complication of the preexisting hydrosalpinx was suspected. Exploratory laparoscopy confirmed torsion of the fallopian tube. Left salpingectomy was performed. Histopathologic study confirmed a fallopian tube with hemorrhagic infarct.

Conclusion
Torsion of the fallopian tube must be considered in the event of acute abdominal pain. Early diagnosis and trying conservative management with a view to preserving fertility in this group of patients are essential.
Hand hygiene compliance in Dutch general practice offices
Authors: Hilt Nataliya , Lokate Mariëtte , OldeLoohuis Alfons , Hulscher Marlies E. J. L. , Friedrich Alex W. , Voss Andreas 
Published: September 2020

Abstract
Background
Hand hygiene (HH) is considered one of the most important measures to prevent healthcare-associated infections (HAI). Most studies focus on HH compliance within the hospital setting, whereas little is known for the outpatient setting. The aim of this study was to evaluate compliance with HH recommendations in general practitioners (GPs) office, based on World Health Organization (WHO) guideline.

Methods
An observational study was conducted at five Dutch GPs-practices in September 2017. We measured HH compliance through direct observation using WHO’s ‘five moments of hand hygiene’ observation tool. All observations were done by one trained professional.

Results
We monitored a total of 285 HH opportunities for 30 health care workers (HCWs). The overall compliance was 37%. Hand hygiene compliance was 34, 51 and 16% for general practitioners, practice assistants, and nurses, respectively. It varies between 63% after body fluid exposure and no HH performance before-, during and after home visit of a patient (defined as moment 5). The preferred method of HH was soap and water (63%) versus 37% for alcohol-based hand rub (ABHR). The median time of disinfecting hands was 8 s (range 6–11 s) for HCWs in our study.

Conclusions
HH compliance among HCWs in Dutch GPs was found to be low, especially with regard to home visits. The WHO recommended switch from hand wash to ABHR was not implemented by the majority of HCWs in 5 observed GPs offices.
Effect of milk fat-based infant formulae on stool fatty acid soaps and calcium excretion in healthy term infants: two double-blind randomised cross-over trials
Authors: Manios Yannis , Karaglani Eva , Thijs-Verhoeven Inge , Vlachopapadopoulou Elpis , Papazoglou Anastasia , Maragoudaki Eleni , Manikas Zafeiris , Kampani Tarek-Michail , Christaki Iliana , Vonk Marlotte M. , Bos Rolf , Parikh Panam 
Published: September 2020

Abstract
Background
Palmitic acid (PA) is predominantly esterified at the SN-2 position of triacylglycerols in human milk. PA at the SN-2 position is more efficiently absorbed and results in reduced formation of PA soaps, as well as reduced fatty acid (FA) and calcium malabsorption. Bovine milk fat (MF), a natural source of SN-2-palmitate, was used in the fat blend of infant formulae (IF) in the current study to investigate its effect on stool fatty acid soaps, calcium excretion and stool characteristics.

Methods
Two double-blind, randomised cross-over trials (CS1, CS2) were conducted in parallel with healthy term, formula-fed infants aged 9–14 weeks. After a two-week run-in period, infants in CS1 (n = 17) were randomly allocated to receive either a 50% MF-based formula (50MF) or a 100% vegetable fat (VF) formula; in CS2 (n = 18), infants received either a 20% MF-based formula (20MF) or the VF formula, in a 2 × 2-week cross-over design. At the end of each two-week intervention period, stool samples were collected for FA, FA soaps and calcium excretion analysis and stool consistency was assessed according to the Amsterdam Infant Stool Scale (AISS).

Results
MF-based groups showed no significant difference in PA in stools compared to VF group, although reduced stool PA soaps (CS1: 111.28 ± 18.33 vs. 220.25 ± 29.35 mg/g dry weight, p < 0.0001; CS2: 216.24 ± 25.16 vs. 233.94 ± 35.12 mg/g dry weight, p = 0.0023), total FA soaps and calcium excretion (CS1: 46.40 ± 5.27 vs. 49.88 ± 4.77 mg/g dry weight, p = 0.0041; CS2: 46.20 ± 4.26 vs. 50.47 ± 6.71 mg/g dry weight, p = 0.0067) were observed. Furthermore, the 50MF group showed a favourable lower mean stool consistency score compared to the VF group (1.64 ± 0.49 vs. 2.03 ± 0.19, p = 0.0008).

Conclusions
While the use of bovine MF in IF did not affect PA concentrations in stool, lower excretion of palmitate soaps, total FA soaps and calcium was seen in healthy term infants. 50MF formula also showed improved stool consistency. The use of MF in IF could be an interesting approach to improve gut comfort and stool characteristics in infants, warranting further research.

Trial registration
Netherlands Trial Registry Identifier: NTR6702. Date registered: December 01, 2017.
An in vitro screening potential traditional medicinal plants for nephrolithiasis
Authors: Shirani Majid , Arjaki Davood , Kheiri Soleiman , Bijad Elham , Mohammadi Sareh , Lorigooini Zahra 
Published: September 2020

AbstractBackgroundToday, the attention of researchers has been drawn to the use of medicinal plant for the treatment of kidney stones. The aim of this study was to investigate the effect of five plants used in traditional medicine on the dissolution of calcium oxalate and calcium phosphate stones. Then, the ability of more effective plants to dissolve stones collected from patients after Percutaneous Nephrolithotripsy was investigated.MethodsThe aerial part of plants were extracted by maceration method. The synthesized stones in laboratory were incubated with different concentrations of the extract. Next, the concentrations of calcium oxalate and calcium phosphate were measured by a calcium kit and BT 3000. The effect of the extract with the best activity on the stones collected from the patients was also studied. The composition of clinical stones was determined by colorimetric method. The total phenolic content (TPC) of the extracts was determined.ResultsThe highest dissolution of calcium oxalate stones was observed by theG. struthiumextract and the highest dissolution of calcium phosphate stones by theA. euchromaandA. officinalisroot extracts. The dissolution percentage of clinical stones by theA. euchromaextract was significantly higher than other extract (P < 0.05). The highest TPC was observed inA. euchromaextract (P < 0.05).ConclusionTheA. euchromaextract exhibited the greatest dissolution activity on laboratory calcium oxalate and calcium phosphate stones as well as clinical stones made of high amounts of calcium oxalate. Therefore, the extract can be effective in preventing and treating kidney stones.
Retrieval of shallow S-wave profiles from seismic reflection surveying and traffic-induced noise
Authors: Zhang Kai , Li Hongyi , Wang Xiaojiang , Wang Kai 
Published: September 2020

In urban subsurface exploration, seismic surveys are mostly conducted along roads where seismic vibrators can be extensively used to generate strong seismic energy due to economic and environmental constraints. Generally, Rayleigh waves also are excited by the compressional wave profiling process. Shear-wave (S-wave) velocities can be inferred using Rayleigh waves to complement near-surface characterization. Most vibrators cannot excite seismic energy at lower frequencies (<5 Hz) to map greater depths during surface-wave analysis in areas with low S-wave velocities, but low-frequency surface waves ([Formula: see text]) can be extracted from traffic-induced noise, which can be easily obtained at marginal additional cost. We have implemented synthetic tests to evaluate the velocity deviation caused by offline sources, finding a reasonably small relative bias of surface-wave dispersion curves due to vehicle sources on roads. Using a 2D reflection survey and traffic-induced noise from the central North China Plain, we apply seismic interferometry to a series of 10.0 s segments of passive data. Then, each segment is selectively stacked on the acausal-to-causal ratio of the mean signal-to-noise ratio to generate virtual shot gathers with better dispersion energy images. We next use the dispersion curves derived by combining controlled source surveying with vehicle noise to retrieve the shallow S-wave velocity structure. A maximum exploration depth of 90 m is achieved, and the inverted S-wave profile and interval S-wave velocity model obtained from reflection processing appear consistent. The data set demonstrates that using surface waves derived from seismic reflection surveying and traffic-induced noise provides an efficient supplementary technique for delineating shallow structures in areas featuring thick Quaternary overburden. Additionally, the field test indicates that traffic noise can be created using vehicles or vibrators to capture surface waves within a reliable frequency band of 2–25 Hz if no vehicles are moving along the survey line.
Hectometer-scale, shallow buried honeycomb-like structures on the continental shelf of the Otway Basin, southeastern Australia
Authors: Niyazi Yakufu , Warne Mark , Ierodiaconou Daniel 
Published: September 2020

The Plio-Pleistocene Whalers Bluff Formation (WBF) of the offshore Otway Basin is composed of mixed siliciclastic-carbonate sediments. In seismic cross sections, this formation includes an interval that consists of higher amplitude seismic reflections that display alternating depressional ponds and raised ridges. This interval is shallowly buried and lies between 40 and 150 ms two-way traveltime below the present-day seafloor. In this study, we have used 2D and 3D seismic data sets in combination with the available shallow subsurface well logs to characterize the geomorphology and investigate the origin of these enigmatic features. The ponds are expressed as densely packed, circular to polygonal, and in some cases, hexagonal-shaped features in time-slice maps, and they closely resemble previously documented honeycomb structures. In our study area, the honeycomb-like structures (HS) are comprised of large (200–800 m diameter range) depressed ponds that are separated by narrow (approximately 20 m at the top) reticulate ridges. In total, these HS cover an area of 760 km2. Geospatial analysis shows that the ponds of HS, especially those in the northeast of the study area, are aligned along the northwest–southeast trend lines. There are several possible origins for the HS. The most probable mechanism is that the HS resulted from the bulk contraction of soft sediment, associated with shallow-burial diagenesis processes such as subaqueous dewatering of the fine-grained successions within the WBF. Interestingly, irregular furrows of various lengths on the seafloor correspond to the ridges of the HS, and we hypothesize that these furrows may have formed due to differential compaction of the underlying alternating ponds and ridges. Our results demonstrate the benefits of using seismic reflection data sets in combination with geospatial analysis to investigate the buried paleogeomorphologic features and their impact on the present-day seafloor physiography.Geological feature: Honeycomb-like, soft sediment deformation associated with shallow-burial diagenesis, Otway Basin, southeastern Australia Cross-section appearance: Alternating depressional ponds and raised ridges Map view appearance: Densely packed, oval to polygonal-shaped features Features with a similar appearance: Acquisition footprints, carbonate mounds/dissolution features, polygonal faults, pockmarks, opal-A to opal-CT transition Formation: Whalers Bluff Formation, offshore Otway Basin Age: Pliocene to recent Location: Continental shelf of the Otway Basin, southeastern Australia Data sets: 2D and 3D seismic reflection data, borehole data, from Geological Survey of Victoria, Australia Analysis tools: Interpretation and visualization (Petrel 2019 and DUG Insight, v.4.7, 2020), Geospatial analysis (ESRI‘s ArcMap 10.5)
PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery
Authors: Risbridger Gail P , Lawrence Mitchell G , Taylor Renea A 
Published: September 2020

AbstractPatient-derived xenografts (PDXs) are tools of the trade for many researchers from all disciplines and medical specialties. Most endocrinologists, and especially those working in oncology, commonly use PDXs for preclinical drug testing and development, and over the last decade large collections of PDXs have emerged across all tumor streams. In this review, we examine how the field has evolved to include PDXs as versatile resources for research discoveries, providing evidence for guidelines and changes in clinical practice.
Un discours « de majesté »
Authors: Vredenburgh Amanda , Bjørnstad Hall 
Published: September 2020

Abstract
Dans cet article, nous proposons le concept du « sublime royal » pour repenser le sublime au dix-septième siècle, avant, avec et autour de Boileau, en nous penchant moins sur l’intervention de Boileau elle-même que sur le contexte qui a rendu sa réussite possible : une situation où toute expression culturelle hégémonique avait avant tout une visée politique, celle de glorifier le monarque absolu. En tant que figure qui présente l’irreprésentable, le sublime permet l’impossible dans la représentation du roi : le présenter comme absolu. Il s’agit là d’un fonctionnement qui est, certes, paradoxal, mais selon un paradoxe qui est constitutif de l’absolutisme lui-même. C’est ce paradoxe constitutif qu’il s’agit d’examiner ici en étudiant, dans un premier temps, quelques exemples représentatifs du discours de l’auto-représentation de l’absolutisme, puis les répercussions plus larges du changement de perspective que nous proposons. En vue d’études ultérieures, nous examinons la façon dont le concept du sublime royal change notre conception de la place des Anciens dans la politique absolutiste, avant de montrer comment le concept de sublime royal contient en germe un nouveau modèle pour penser le développement de l’assentiment affectif à l’absolutisme et la manière dont les sujets y participent.
L’Année pornographique
Authors: Rexer Raisa 
Published: September 2020

AbstractThis essay explores the sudden popularity and redefinition of the word pornographie in France in the 1880s. Following the publication of Émile Zola’s novel Nana and the rise of a genre of cheap, bawdy newspapers in 1880, the French daily press knowingly “invented” the word pornographie to designate these sexually explicit publications. Reviving an esoteric word, the press redeployed it with a new meaning and a (concocted) origin narrative that highlighted both the word’s “newness” and Zola’s place in the “new” genre it designated. This reinvention and deployment of the word were driven by the evolving politics and economics of the daily press during the first decades of the Third Republic. Ultimately, this politically motivated, half-fabricated reinvention of the word pornographie culminated with its becoming the catchall term that would all but replace obscenity as a signifier of sexually charged representation in the twentieth century.
Demons of Analogy
Authors: Paul Zakir 
Published: September 2020

AbstractWidely considered the first French-language photo narrative, the use of images in Bruges-la-Morte (1892) tends to occlude as much as it reveals. Drawing on archives and contemporary debates about the image, this article contends that photography structures the novel on a formal level by reinforcing its poetics of analogy, a project that connects Georges Rodenbach’s oeuvre to the larger symbolist movement from Baudelaire to Mallarmé. Rodenbach’s novel attempts to invent a tradition of symbolist prose, which provocatively locates a shared likeness in otherwise dissimilar literary and pictorial practices. The aura of Bruges is used to explore the nature and limits of analogy—a term shared by symbolism and photography—leading to a critique of forms of identification that conflate difference with similitude.