bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic role of preoperative neutrophil-to-lymphocyte ratio and albumin for 30-days mortality in patients with postoperative acute pulmonary embolism
Authors: Liu Chuan , Zhan Hui-lu , Huang Zhang-Heng , Hu Chuan , Tong Yue-Xin , Fan Zhi-Yi , Zheng Meng-Ying , Ma Gui-Yun , Song You-Xin , Zhao Cheng Liang 
Published: January 2020

Abstract
Background This retrospective study aimed to investigate the prognostic value of neutrophil–lymphocyte ratio (NLR) and albumin in 30-days mortality in patients with postoperative acute pulmonary embolism (PAPE).Methods We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012 to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30-days after PAPE were obtained from our electronic medical recording system and follow up. The association between NLR, PLR, and other predictors and 30-days mortality were analyzed with univariate and multivariate analyses. Then, the nomogram include the independent predictors was established and evaluated.Results 24 patients died within 30 days corresponding to 30-days mortality of 23.8%. The results of the multivariate analysis indicated that both NLR and albumin are independent predictors for 30-days mortality in patients with PAPE. The probability of death increased about 17.1% (OR=1.171, 95% CI: 1.073–1.277, P=0.000) with one unit of increase of NLR, and the probability of death decreased about 15.4% (OR=0.846, 95% CI: 0.762c–0.939, P=0.002) with one unit of increase of albumin. The area under the curve of nomogram was 0.888(95%CI:0.812-0.964).Conclusion Our findings showed that Elevated NLR and decreased albumin were related with poor prognosis in patients with PAPE. The NLR and albumin were independent prognostic factor for PAPE.
Prognostic significance of serum osteopontin levels in small-cell lung cancer
Authors: Xu Chunhua , Yuan Qi , Wang Wei , Chi Chuanzhen , Zhang Qian , Li Li , Yang Rusong , Wang Yuchao 
Published: January 2020

Abstract
BackgroudOsteopontin (OPN) is involved in the development and metastasis of a variety of tumors. This study explored serum OPN levels in patients with small cell lung cancer (SCLC) and compared them with healthy controls.MethodsThe OPN levels of 96 patients with SCLC before and after first-line chemotherapy were detected by enzyme-linked immunosorbent assay (ELISA) and compared with 60 healthy controls.ResultsThe pre-treatment serum OPN levels of patients with SCLC were higher than those of healthy controls (P<0.001). Serum OPN levels were significantly associated with disease stage, tumor size, and lymph node metastasis (P=0.012, 0.034, and 0.037, respectively). Serum OPN levels were significantly decreased after first-line chemotherapy (P=0.019), which was associated with treatment response (P=0.011), but there was no significant difference with pre-treatment OPN levels (P=0.485). Cox proportional hazard analysis showed that serum OPN levels, disease stage, and performance status were independent predictors of overall survival.ConclusionsOur results suggest that serum OPN levels can be used as biomarkers to predict treatment response and survival in patients with SCLC.
Quantitative atomic force microscopy measurements of Acinetobacter morphology
Authors: Lostroh C. Phoebe , Boyd Caroline M. , Lammers Nicholas , Roush Kaleb S. , Worsham Sara L. , Maravilla Saúl , Buttar-Miller Anis , Lang Kristine M. 
Published: January 2020

Abstract
Acinetobacter baylyi are variously reported as spherical or rod-shaped. Here we use atomic force microscopy (AFM) to make quantitative nanometer-scale measurements of cellular length and width for thousands of individual cells. We quantify the heterogeneity of populations grown in varying environmental conditions that dramatically affect cell shape. In particular, we look at morphology changes across a growth curve, and we examine cells from populations grown in various growth media. We also examine the morphology of a minC mutant, which suggests an interpretation for the morphological types observed in wild type cells.
Plant defensin antibacterial mode of action against Pseudomonas species
Authors: Sathoff Andrew Edward , Lewenza Shawn , Samac Deborah A. 
Published: January 2020

Abstract
Background: Though many plant defensins exhibit antibacterial activity, little is known about their antibacterial mode of action (MOA). Antimicrobial peptides with a characterized MOA induce the expression of multiple bacterial outer membrane modifications, which are required for resistance to these membrane-targeting peptides. Mini-Tn5-lux mutant strains of Pseudomonas aeruginosa with Tn insertions disrupting outer membrane protective modifications were assessed for sensitivity against plant defensin peptides. These transcriptional lux reporter strains were also evaluated for lux gene expression in response to sublethal plant defensin exposure. Also, a plant pathogen, Pseudomonas syringae pv. syringae was modified through transposon mutagenesis to create mutants that are resistant to in vitro MtDef4 treatments.Results: Plant defensins displayed specific and potent antibacterial activity against strains of P. aeruginosa. A defensin from Medicago truncatula, MtDef4, induced dose-dependent gene expression of the aminoarabinose modification of LPS and surface polycation spermidine production operons. The ability for MtDef4 to damage bacterial outer membranes was also verified visually through fluorescent microscopy. Another defensin from M. truncatula, MtDef5, failed to induce lux gene expression and limited outer membrane damage was detected with fluorescent microscopy. The transposon insertion site on MtDef4 resistant P. syringae pv. syringae mutants was sequenced, and modifications of ribosomal genes were identified to contribute to enhanced resistance to plant defensin treatments. Conclusions: MtDef4 damages the outer membrane similar to polymyxin B, which stimulates antimicrobial peptide resistance mechanisms to plant defensins. MtDef5, appears to have a different antibacterial MOA. Additionally, the MtDef4 antibacterial mode of action may also involve inhibition of translation.
Profile of common inflammatory markers in treatment-naïve patients with systemic rheumatic diseases
Authors: Kim Min Jung , Lee Eun Bong , Song Yeong Wook , Park Jin Kyun 
Published: January 2020

Abstract
Background The host inflammatory response against infection is characterized by leukocytosis, and the release of cytokines and acute phase proteins. However, routine inflammatory markers are not always elevated in systemic rheumatic diseases (SRD). Here, we aimed to systematically evaluate and compare the clinical implications of common inflammatory markers in systemic rheumatic diseases (SRDs). Methods We investigated the profiles of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and white blood cell (WBC) count in treatment-naïve patients with SRDs, osteoarthritis and pneumonia diagnosed at Seoul National University Hospital during 2004-2016. SRDs included rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), systemic sclerosis (SSc), idiopathic inflammatory myopathy (IIM) and adult onset of Still disease (AOSD). Associations between inflammatory markers were evaluated using Pearson’s correlation and regression analysis. Differences between correlations were compared using Steiger’s z-test. Receiver operating characteristic (ROC) curve analysis was performed to examine the predictive value of inflammatory markers for SRD diagnosis. Results We identified 1191 patients with SRDs, osteoarthritis and pneumonia. Leukocytosis was present in <15% SRD patients. There was marked variability in ESR and CRP levels among different SRDs. The highest mean CRP levels (mean ± SD, mg/dL) were observed in those with AOSD (11.3±7.9), followed by RA (2.0±3.3), IIM (1.8±3.5), SLE (1.5±3.1), SSc (0.6±1.3) and AS (0.08±0.1). Mean ESR (mm/hr) was also highest in AOSD (71.2±31.0), followed by SLE (47.3±34.2), RA (45.5±30.6), IIM (40.8±24.8) and SSc (27.8±26.0). All SRDs showed significant positive correlations between ESR and CRP: greatest in RA (r=0.53, p<0.001) and weakest in SLE (r=0.20, p=0.03). WBC correlated weakly with CRP but not with ESR in most SRDs. While the AUC for WBC count (0.54-0.68) was less than that of ESR or CRP, the AUC for ESR and CRP (0.69-0.86) were similar in SRD. The optimal cuff-off values for inflammatory markers predicting SRD were within or slightly above the normal limit. Conclusions Unlike acute infection, ESR, CRP and WBC count are not always elevated in treatment-naïve patients with SRD. Thus, common inflammatory markers have limited value for diagnosis and assessment of disease activity of SRD.
A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke
Authors: Wang Yan , Gu Xi-Xi , Huang Hua-Tuo , Liu Chun-Hong , Wei Ye-Sheng 
Published: January 2020

Abstract
Background: Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases, and especially plays an important role in nerve injury including promotion of angiogenesis, inhibition of apoptosis and inflammation, regulation of autophagy, which are closely linked to the pathological processes of ischemic stroke (IS). However, the effect of genetic variation (single nucleotide polymorphisms, SNPs) of MALAT1 on IS have rarely been explored. This study aimed to investigate whether polymorphisms in promoter of MALAT1 were associated with the susceptibility to IS. Methods: A total of 316 IS patients and 320 age-, gender-, and ethnicity-matched controls were enrolled in this study. Four polymorphisms in the promoter of MALAT1 (i.e., rsrs600231, rs1194338, rs4102217, and rs591291) were genotyped using a custom‐by‐design 48‐Plex SNPscan kit. Results: The rs1194338 C>A variant in MALAT1 promoter was associated with IS risk (AC vs. CC: adjusted OR = 0.623, 95% CI, 0.417-0.932, P = 0.021; AA vs. CC: adjusted OR = 0.474, 95% CI, 0.226-0.991, P = 0.047; Dominant model: adjusted OR = 0.596, 95% CI, 0.406-0.874, P = 0.008; A vs. C adjusted OR = 0.658, 95% CI, 0.487-0.890, P = 0.007). The Haplotype analysis showed that rs600231-rs1194338-rs4102217-rs591291 (A-C-G-C) had a 1.3-fold increase of IS risk (95% CI, 1.029-1.644, P=0.027). Logistic regression analysis identified some independent impact factors for IS including rs1194338 AC/AA, TC, TG, HDL-C, LDL-C, Apo-A1, Apo-B and NEFA(P < 0.05). Conclusions: These results suggest that the rs1194338 AC/AA genotypes may be a protective factor for IS.
A PRELIMINARY RESULT OF AIR QUALITY IDENTIFICATION AND ANALYSIS OF PM10 AND PM2.5 IN STEEL INDUSTRIAL AREA, CILEGON, BANTEN
Authors: Setiawati Ira , Ermawati Rahyani , Kang Kitai , Chang Insoo , Hong Kihwan , Ervina Ervina , Ariani Auliyah , Fauzi Ilham , Syah Indra Lukman , Sefriana Fita , Sari Yesy Komala 
Published: January 2020

The increasingly rapid industrial development has produced pollutants in the form of gases and particles polluting the atmosphere. One of them is the steel industry where the majority of the air pollutants produced is particulate matter. Monitoring the air quality of particulate matter needs to be done routinely to identify and control the effects of air pollution somewhere. The purpose of this study is to identify and analyze particulate matter (PM10 and PM2.5) in the steel industry area in Cilegon, Indonesia. Ambient particulate matter is sampling by low-volume Sequential Particulate Matter (PM) Sampler with flow rate 5-20 L/minute for 24 hours per day in 4 months from September 2018 to January 2019. The results of identification and analysis of PM10 and PM2.5 in the steel industry area, Cilegon, Indonesia showed concentrations that varied greatly depending on sampling location conditions, with an average concentration range of 89.38 - 141.13 µg/m3 for PM10 and 21.74 - 50.69 µg/m3 for PM2.5.
WASTE TO PRODUCT: BISOLUM-BRICKS, INCORPORATION OF WWTP SLUDGE OF TEXTILE INDUSTRY INTO BRICKS FOR WALL PAIRS
Authors: Arbunowo Armas Arifin , Purwanto P. Purwanto , Budihardjo M. Arief 
Published: January 2020

The disposal of WWTP sludge is one of problems in textiles industry, which requires serious attention to find a way out. Utilization of sludge from the textile industry wastewater treatment, according to the Republic of Indonesia Goverment Regulation No.110 year 2014, can be used as a mixture of brick raw materials, must consider the availability of technology, meet environmental quality standards and meet technical requirements for use.Environmental feasibility refers to Goverment Regulation No.110 year 2014, carried out with TCLP toxicity tests on raw materials for soil, WWTP sludge and brick products. Acute toxicity test LD 50, carried out on brick products in which using a mixture of WWTP Sludge. Technical feasibility is carried out by testing the quality of brick products in accordance with solid brick Nasional Indonesian Standard (SNI) for wall pairs.Research results prove the toxicity test on raw materials and brick products with a mixture of up to 60% of waste, still meets the requirements of TCLP and LD.50 according to GR No.110 year 2014. Test the quality of bricks at the use of 40% and 60% mixture of sludge still meet Nasional Indonesian Standard (SNI 15-2094-2000) solid red brick for wall pairs.
Teacher’s Technological Pedagogical Content Knowledge in Developing Learning Materials
Authors: Wulandari Ella 
Published: January 2020

The provision of appropriate learning materials is essential in curriculum enactment as the prescribed competences and learning method are usually advised in textbooks supplied to support its implementation. However, government-supplied textbook cannot always ad­dress schools’ and students’ different needs. Teachers are, therefore, required to have the skills to develop their own learning materials to meet curriculum. In Indonesia, higher or­der thinking skills (HOTS) and technology are required to be integrated in the teaching and learning activities of all subjects including English. It is, then, important to survey teacher’s knowledge in materials development to help them acquire the required skills in developing materials in line with curriculum. This paper presents a survey study on junior secondary school teachers in Yogyakarta about their technological pedagogical content knowledge. A questionnaire was administered followed by an interview with selected teach­ers for further elaboration. The instrument was adapted from Schmidt et al (2009) and aimed to reveal teacher’s knowledge on teaching and technology and how they apply this knowledge into materials development processes. The finding suggests aspects of teacher’s knowledge that need further training and possible effective methods for their training as well as professional development design.Keywords: curriculum, materials development, teacher’s knowledge
Education, Pedagogy, and Identity: The notion of historical, political, and sociopolitical experiences of Indonesia in educational research
Authors: Ikasari Wipsar Siwi Dona 
Published: January 2020

Schooling and education are situated contexts to understand issues of identity, culture, representation, and agency (Giroux, 1996). Schools are shaped by specific cultural practices and values which reflect the norms of a particular society for which they have been developed (Hollins, 1996). For example, education and schooling in Indonesia is one of the situated contexts to scrutinize the concept of ‘Indonesian young girls’ and ‘Indonesian schoolgirls’ (Muthali’in, 2001; Blackburn, 2004; Smith-Hefner, 2005). Using the conceptual frameworks of gender, identity and schooling, the schoolgirls identify themselves of being Indonesian girls shaped by their ethnic and religious affiliations. The inextricable link between ethnicity and religion in Indonesia has been continuously shaped within the historical, cultural politics in Indonesia, from the ancient time, the Old Order, New Order, Reformation and Post-Reformation Era. Within the Indonesian context, religious values and social norms hold by the society is important because cultural development contributes to the image of Indonesia as a country (Junarsin, 2009). Keywords: Indonesian schoolgirls, academic achievement, identity, education
EFEKTIFITAS PENAMBAHAN ASAM AMINO PADA PAKAN UNTUK PERTUMBUHAN IKAN SIDAT, Anguilla bicolor (McCelland, 1844)
Authors: Pratama Ricky Hadi , Tarsim Tarsim , Yudha Indra Gumay 
Published: January 2020

Eel is one of the fisheries commodity that have not been rearing widelyin Indonesia. Constraint that occured in rearing eel is slow growth. A way to accelerate eel growth isfeeding with enrichment by using an amino acids. An amino acids can be used directly by eel for cell growth and the formation of body tissue. An amino acid that is used from the stingrays are not utilized by people because it has no economic value to production activities. This research was aimed to study the growth rate of eel whichis fed with enrichment of an amino acids derived from stingray extract. The method in this research used completely randomized design (CRD) with 3 treatments and 3 replications. The measure of eel that usedare 26-28 cm, the average weight is 28 grams and an amino acids dosage that used are 0 ml, 0.5 ml and 1 ml. It use FR 3% which is given at night to support the characteristic of eel that is nocturnal (active at night). The analyze result from the parameters that have been observed, there is not a significant effect (P> 0.05) and the fed with enrichment by using an amino acids with the dosage used hasn't been able to be utilized as fish feed mixture to increase growth rate.
KONSEP PENDIDIKAN IKHWAN AL-SHAFA DAN RELEVANSINYA DENGAN DUNIA POSTMODERN
Authors: Afandi Rahman 
Published: January 2020

Abstract: The Ikhwan al-Shafa is an organization established by a group of people (mujtahidin) consisting of philosophers, who focused their attention on the field of da'wah and education, that developed at the end of the second century Hijrah in the city of Basra, Iraq. It is a discussion and teaching forum. In general, its emergence is motivated by concerns about the implementation of Islamic teachings that have been contaminated by teachings from outside Islam at that time, and to revive love for science among Muslims. They compiled 51 agreements known as the "Rasail Ikhwan al-Shafa" (Ikhwan al-Shafa agreement). The background of Rasail Ikhwan al-Shafa writing came from dissatisfaction with the implementation of the Islamic education and lifestyle at that time. This organization viewed education with a rational and empirical view, or a combination of intellectual and factual views. They viewed science as a description of something that could be known in nature, the knowledge produced by human thought occurs because it receives information materials sent by the five senses. Some of the Ikhwan al-Shafa's concepts or thoughts about education have an urgent relevance to education that is applied in the current postmodern era. Whether it's how to get knowledge, teacher competency standards, goals, curriculum and methods that are used.
Keywords: Concept, Education, Ikhwanas-Shafa, Relevance, Postmodern.
Using a Multi - function Pressure Valve in Volumetric Hydraulics Drives
Authors: Efremova K. D. , Pilgunov V. N. 
Published: January 2020

The paper deals with using hydraulic equipment for pressure and flow control in volumetric hydraulic drives to control a throttle movement speed of the output link of an executive hydraulic motor. Depending on the type of problem to be solved, hydraulic equipment is divided into the pressure and flow control, and the shutoff and regulating elements used in equipment are divided into those of valve and spool type. The main paper objective is to analyse designs and feasibilities for using a multi-functional pressure valve to solve real-life problems of control in a volumetric hydraulic drive. The paper presents a multi-function indirect pressure valve design of DZ standard size (Rezroth Bosch Group) and its detailed principle of operation. In the multifunctional pressure valve design there are threaded plugs, the combination of which allows us to control the pilot valve, using the pressure in the hydraulic system (internal control) or the pilot valve control from an external pressure source. Pilot drainage to the valve outlet port (internal drainage) or drainage directly to the tank is possible. It is shown that the term “Load Sensing System” that is used in Western equipment to mean “control based on load magnitude” can be correctly used to describe designs for using a multifunctional valve.Issues on setting up internal functional communications of the valve to select feed modes of a pilot valve and its drainage have been fully considered. By examples of using a multifunctional pressure valve, the valve operation capabilities are shown, namely as an overflow valve, a sequence one, its operation in the balancing scheme of the gravity load and as part of a hydraulic drive with alternating load. The use of multi-function pressure valve in presses allows us to increase the pressing force through using the weight of the punch. The article belongs to the category of systems engineering, and the represented options of the using valve can be applied when designing the volumetric hydraulic drives with throttle control of the movement speed of the output link in hydraulic drives.
On Linear Independence of Some Functions
Authors: Ivankov P. L. 
Published: January 2020

To study an arithmetic nature of the values of hyper-geometric functions (and their derivatives including those with respect to parameter), it is common practice to use one either Siegel's method or the method based on the effective construction of the linear approximating form. The main distinction between these methods consists in the mode of construction of the first approximating form. Applying Siegel's method allows us to construct such a form by means of a pigeonhole principle that makes it possible to establish, in certain cases, the algebraic independence of the values of corresponding functions. The Siegel's method can be usually applied just while considering hyper-geometric functions with rational parameters. The effective method has a certain advantage here, for in some cases this method enables us to carry out corresponding investigation also for the functions with irrational parameters. Another advantage of the effective method is that it provides obtaining of high- accuracy quantitative results. By quantitative results one usually implies the estimates of the moduli of the linear forms in the values of corresponding functions. The effective method has made it possible to obtain, in some cases, estimates being precise regarding the height of such forms with calculation of the corresponding constants. A drawback of the effective method is the narrow domain of its applications. The effective construction of the linear approximating form, which initiates reasoning, is always a challenge. So far, an effective construction of the approximating form for the product of powers of hyper-geometric functions (with the rare exceptions) failed.In both aforementioned methods one proves previously linear independence (in Siegel's method, as a rule, algebraic independence,) of the functions under consideration. Such a proof is often considered as an independent result.In this paper, by means of the method especially elaborated for this purpose we establish linear independence of some hyper-geometric functions and their derivatives (including those with respect to parameter) over the field of rational fractions. Subsequently, it will be possible to apply this result to investigate arithmetic properties of the values of such functions. Herewith we mean the application of the effective method to achieve the sufficiently accurate quantitative result.