bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Hand Eczema is a Type 2 Disease: Evidences from Integrated Clinical Trial and Molecular Profiling
Authors: Tauber Marie , Gery Perrine , Du-Thanh Aurélie , Bérard Emilie , Jendoubi Fatma , Ekren Rüçhan , Lenief Vanina , Rimet Hugo , Raison-Peyron Nadia , Bouznad Amel , Konstantinou Maria-Polina , Rioual Jonathan , Basso Lilian , Mouiren Juliette , Boussier Manon , Milpied Brigitte , Bulai-Livideanu Cristina , Jaulent Louise , Hacard Florence , Lefèvre Marine-Alexia , Nosbaum Audrey , Seneschal Julien , Vocanson Marc , Paul Carle , Gaudenzio Nicolas 
Published: December 2024

Abstract

Background. Chronic hand eczema (CHE) is a debilitating skin condition characterized by pain, itch, and chronic inflammation, with a complex multifactorial origin. Its diverse presentations, including overlapping traits of atopic dermatitis, contact dermatitis, and psoriasis, make diagnosis and treatment particularly challenging. Despite being the most common occupational skin disease, the underlying immune mechanisms of CHE remain poorly understood. Methods. Here we conducted a comprehensive molecular profiling of CHE patients of all etiologies and morphologies and performed a phase 2b randomized, multicenter, double-blind, placebo-controlled clinical trial comparing dupilumab to placebo over 16 weeks.
Results. We demonstrated that CHE is a type 2 immunity driven disease, regardless of etiological factors or clinical presentation. Transcriptomic profiles of CHE patients closely resemble those seen in both atopic dermatitis and psoriasis, with dysregulated genes affecting skin barrier function, leukocyte migration, cytotoxicity, and mixed type 1, 2, and 3 immunity. The clinical trial included 94 adults with moderate to severe CHE persisting for at least six months and resistant to potent topical corticosteroids. Compared to placebo control, 16-week dupilumab treatment significantly improved clinical severity and quality of life of CHE patients, while largely restoring appropriate transcriptomic and proteomic programs related to skin barrier and immune homeostasis.
Conclusion. These findings demonstrate that IL-4Rα signaling is a critical regulator of CHE pathological features, independent of atopic dermatitis background or environmental triggers and support reclassifying CHE as a type 2 immune disorder, positioning dupilumab and IL-4/13 targeted therapies as leading treatments for moderate-to-severe patients.
Physicochemical Compatibilities: Analyzing Aspects in Four Different Mixtures
Authors: Özyürek Ahmet , Yeşilyurt-Dirican Zeynep Elif 
Published: December 2024

Abstract

Purpose: The study investigates the physicochemical compatibility of four drug mixtures commonly used in emergency departments. It aims to address the limited data on intravenous incompatibilities and to enhance clinical practice by identifying potential risks.
Methods: Mixtures of pheniramine-dexamethasone, diclofenac-metoclopramide, hyoscine-N-butylbromide-pantoprazole, and metoclopramide-pantoprazole were prepared under simulated emergency department conditions. pH changes were measured at multiple time points (0–60 minutes), and optical density was assessed using a spectrophotometer at specified wavelengths. Visual inspections were conducted immediately after preparation and at regular intervals to detect colour changes, turbidity, precipitation, and gas formation. Compatibility evaluation integrated all these parameters to provide a comprehensive assessment.
Results: The diclofenac-metoclopramide mixture exhibited visible turbidity and significant optical density changes (up to 1.89), indicating physical incompatibility. Yellowing was observed in pantoprazole-containing mixtures after 24 hours, raising concerns about stability or incompatibility. Minimal pH changes were recorded across all mixtures, with the largest difference being ±0.3 units. Pheniramine-dexamethasone demonstrated high stability with negligible optical density variations.
Conclusion: The diclofenac-metoclopramide mixture is unsuitable for clinical use due to physical incompatibility. Pantoprazole-containing mixtures require further investigation. This study highlights the need for comprehensive compatibility data and recommends cautious use of empirically prepared drug mixtures in emergency settings.
Uncovering Hidden Pathways: Structural Brain Networks Underpinning Connected Speech in Post-Stroke Aphasia
Authors: Duh Ping-Jung , Sederias Ioana , Zimmerer Vitor , Akkad Haya , Leff Alex , Hope Thomas , Crinion Jenny 
Published: December 2024

Abstract

Individuals with post-stroke aphasia (PWA), an acquired language disorder, face significant communication challenges essential for daily life. Surprisingly, little is known about how brain damage following stroke disrupts the anatomical integration of language and multiple-demand brain networks required for speech production. To address this, we used a measure of brain structural network efficiency (SNE) to investigate the anatomical correlates of spoken language abilities in 36 chronic PWA. Connected speech abilities were correlated with higher SNE not only within the left (dominant) language network but also with bilateral language and multiple-demand networks. Post-hoc analyses found: 1) word-level language behaviours were associated solely with discrete left temporoparietal lesions, using voxel-based correlational methodology; 2) using canonical variate analysis, SNE was primarily sensitive to higher-level language behaviours, loading additional brain-behaviour variance beyond distributed voxels. Taken together, our findings illustrate how speech abilities in PWA rely on distributed bilateral networks, outlining higher-level language-cognition interplay.
All-cause mortality risk in elderly patients with femoral neck and intertrochanteric fractures: a predictive model based on machine learning
Authors: Aoying Min , Liu Yan , Fu Mingming , Hou Zhiyong , Wang Zhiqian 
Published: December 2024

Abstract

Background With the aging of the population, the number of elderly patients with hip fracture is gradually increasing, and hip fracture is one of the fractures with the highest mortality rate. The aim of this study was to identify the influencing factors for all-cause mortality in elderly patients with intertrochanteric and femoral neck fractures and to construct predictive models.
Methods This study retrospectively collected elderly patients with intertrochanteric fracture and femoral neck fracture who underwent hip fracture surgery in the Third Hospital of Hebei Medical University from January 2020 to December 2022. Cox proportional hazards regression and Kaplan-Meier curves were used to explore the association between fracture type and mortality. Boruta algorithm was used to screen the risk factors related to death. Multivariate logistic regression was used to determine the independent risk factors, and a nomogram prediction model was established. The ROC curve, calibration curve and DCA decision curve were drawn by R language, and the prediction model was established by machine learning algorithm. The association between continuous variables and outcomes was assessed using restricted cubic splines (RCS).
Results A total of 1373 patients were enrolled in this study. Multivariate COX regression analysis showed that fracture type was independently associated with all-cause mortality. K-M survival curve showed that the mortality of patients with intertrochanteric fracture was higher than that of patients with femoral neck fracture. Compared with patients with femoral neck fracture, patients with intertrochanteric fracture have a higher incidence of perioperative DVT, anemia and delirium. There were 6 variables that remained in the model for intertrochanteric fractures: age (HR 1.048, 95% CI 1.014–1.083, p = 0.006), AMI (HR 4.631, 95% CI 2.190–9.795, P<0.001), COPD (HR 3.818, 95% CI 1.516–9.614, P= 0.004), CHF (HR 2.743, 95% CI 1.510–4.981, P= 0.001), NOAF (HR 1.748, 95% CI 1.033–2.956, P= 0.037), FBG (HR 1.116, 95% CI 1.026–1.215, P= 0.011). There were 3 variables that remained in the model for femoral neck fractures: age (HR 1.145, 95% CI 1.097–1.196, P<0.001), HbA1c (HR 1.264, 95% CI 1.088–1.468, P=0.002), BNP (HR 1.001, 95% CI 1.000–1.002, P= 0.019). The experimental results showed that the model has good identification ability, calibration effect and clinical application value.
Conclusion Intertrochanteric fracture is an independent risk factor for all-cause mortality in elderly patients with hip fracture, and the prognosis is poor. By constructing a prognostic model based on machine learning, the risk factors of mortality in patients with intertrochanteric fracture and femoral neck fracture can be effectively identified, and the perioperative management can be strengthened to develop personalized treatment strategies.
Diverse but declining? Population genetic structure and genetic diversity of Nathusius’ pipistrelle along the Dutch coastline during the autumn migration period
Authors: Schaik Jaap van , Schuler Samuel , Stienstra Karina , Janssen René , Dekeukeleire Daan , Boshamer Jan P.C. , Noort Bart , Steenbergen Josien , Lagerveld Sander 
Published: December 2024

Abstract

Migratory bats are experiencing substantial increases in mortality risk from wind energy developments, but data on their migratory behavior and population dynamics are often lacking. Here, we develop a novel microsatellite panel for one such migratory bat species, the Nathusius’ pipistrelle (Pipistrellus nathusii), and apply it to 448 samples collected at stopover sites along the Dutch coast during autumn migration over four consecutive years. With this dataset, we assessed whether the population is genetically sub-structured, characterize its current genetic diversity, and evaluate whether mothers guide their offspring during migration. We found that the population is panmictic and diverse, with an effective population size estimate that cannot be distinguished from infinite. However, we also observed a consistent decline in allelic richness across the sampling period, as well as a heterozygote excess in individuals sampled as juveniles, both suggesting an ongoing population decline. We did not find any parent-offspring pairs in our dataset, which included 30 box captures where adult female and juvenile bats were found roosting together, suggesting that juvenile bats do not follow their mothers during their first migration. Our findings provide an initial characterization and baseline measure of genetic diversity for the Nathusius’ pipistrelle that can be used as a reference for subsequent studies and systematic efforts to monitor the genetic diversity of the species. Given that monitoring population trends of migratory bat species with traditional methods remains challenging, such tracking of genetic diversity may offer a valuable proxy by which to observe substantial population declines if they occur.
The Impact of the new Occupational Health Regulation in Tunisia
Authors: Benkhalifa Abdelaziz 
Published: December 2024

Abstract

In 1995, the Tunisian government realized a total reform of the occupational insurance system. Since that date, more generous compensation in case of accidents or injuries was introduced and brands of new safety standards (inspection, prevention programs and infraction, etc.) were adopted. In addition, an experience rating system (“Bonus-malus”) was introduced. This paper examines the effectiveness of the new workers' compensation system in improving the health and safety of workers, as well as the effect of new preventive and regulatory measures on occupational risk in Tunisia. The results suggest that the generosity of the new worker’s compensation system is reflected both in the increased of the frequency and the severity of accidents in Tunisia. Regarding the preventive policies adopted in Tunisia, they have, at best, resulted in a minor decrease in the frequency of accidents without having a significant effect on the severity of accidents.
Classification JEL: I13, I18, J28
Foucauldian Influence on Sustainable Plastic Waste Management Behaviors Among Olabisi Onabanjo University Undergraduates, Nigeria
Authors: SOLAJA Oludele Mayowa , OSIFO Omosat Kelly 
Published: December 2024

Abstract

This study investigates how Foucauldian ideas affect undergraduates at Olabisi Onabanjo University in Nigeria to adopt sustainable practices for reducing plastic waste. It aims to comprehend how Foucault's historical ontology of subjects, subjectivation, and self-practices might inspire tactics for promoting sustainable behaviours, particularly in the reduction of plastic waste. The study attempts to do this by investigating how subjectivation changes individual attitudes and behaviours towards minimising plastic waste, as well as how discourses and power dynamics influence self-practices that lead to sustainable behaviours. The study also intends to evaluate the efficacy of interventions that target subjectivation and self-practices in encouraging sustainable behaviours in plastic trash reduction. The theoretical foundation of the study is based on Foucauldian theory, social practice theory, behavioural change theories, environmental psychology, and systems theory. To achieve these goals, a descriptive study approach was used, with qualitative data collecting and content analysis. Undergraduate students from Olabisi Onabanjo University in Nigeria participated in the qualitative data gathering. Their findings offer important views on sustainable behaviours and approaches for reducing plastic waste. The findings of this study have the potential to inform the development of more effective interventions and methods for combating plastic waste pollution, adding to global environmental sustainability initiatives.
Using EEG to Assess Cognitive Fatigue in Real Time: A Medical Simulation Study
Authors: Krigolson Olave E. , Howse Harvey , Hammerstrom Mathew R. , Walzak Ali , Hecker Kent G. 
Published: December 2024

Abstract

Medical mistakes made while in a state of cognitive fatigue result in diagnostic errors, psychological distress, poor patient outcomes, and potentially, loss of life. To date, cognitive fatigue in health professionals is assessed via self-report, however the reliability and validity of these measures are often challenged. Here we propose the use of mobile electroencephalography (mEEG) in a medical context as an objective cognitive fatigue assessment that is cost effective, reliable, and efficient. We had medical students complete a simulated night on-call during which they diagnosed a series of simulated medical cases. Before and after their shift, we assessed cognitive fatigue using both behavioural and mEEG measures. Our results demonstrate a decrease in the amplitude of a neural response sensitive to cognitive fatigue from the start to the end of the simulated night on-call – a finding associated with an increase in cognitive fatigue. Interestingly, we observed no relationship between the neural response and subjective self-reported cognitive fatigue scores supporting the need for objective as opposed to subjective measure when assessing cognitive fatigue.
КОРОТКОЕ ИСТОРИЧЕСКОЕ ВРЕМЯ
Authors: Хвостова К.В. 
Published: December 2024

Короткое историческое время определяется как ситуационное и как повторяющиеся функциональные связи факторов в пределах определенного временно́го интервала. Рассматривается кайрологическое историческое время. Анализируется короткое историческое время, противостоящее историческому агенту. Рассматривается проблема связи идей позитивизма и современного постпозитивизма. Анализируются факты релятивизма в современной исторической науке. Выводы иллюстрируются на материале источников по истории Византии.
Short historical time is determined as situational and as repeated functional connections of social factors within certain temporal intervals. Kairologique historical time is examined. Short historical time set in opposition to actions of historical agents is analyzed. The connection of ideas of positivism and post-positivism is studied. Relativism in contemporary historical science is analyzed using the examples of material of history of Byzantium.
«ХАЗАРСКАЯ ЛЕГЕНДА» В СИСТЕМЕ ПРЕДСТАВЛЕНИЙ КАЗАЦКОЙ СТАРШИНЫ (КОНЕЦ XVII – НАЧАЛО XVIII В.)
Authors: Степанов Д.Ю. 
Published: December 2024

В статье рассматривается проблема формирования этнической идентичности казацкой старшины в конце XVII – начале XVIII. В центре исследования – проблема возникновения и «функционирования» т.н. «Хазарского мифа» – легендарной версии о происхождении украинских казаков (или исключительно их названия) от раннесредневековых хазар.
This article explores the formation of ethnic identity of the Cossack military elite in the late 17th early 18th c. The main problem of this research is the formation of the Ukrainian Cossack origin’s legend from Khazars, or “The Khazar myth”.
This article explores the formation of ethnic identity of the Cossack military elite in the late 17th early 18th c. The main problem of this research is the formation of the Ukrainian Cossack origin’s legend from Khazars, or “The Khazar myth”.
«И ЗНАЧИТ НАМ НУЖНА ОДНА ПОБЕДА…ПАМЯТЬ О ПОБЕДЕ В СОВЕТСКОЙ И РОССИЙСКОЙ ШКОЛЕ
Authors: Линченко А.А. , Головашина О.В. 
Published: December 2024

В статье рассматривается трансформация практик коммеморации 9 мая в школе на примере образовательных учреждений Тамбовской и Липецкой областей. Современный российский опыт анализируется в контексте сравнительного анализа празднования 9 мая в советской школе. Источниками исследования послужили материалы социальных сетей, новостных сайтов школ, а также официальная и нормативная документация школ и отделов образования. На основе идей Э. Дюркгейма, Р. Беллы и Дж. Олика, авторы обосновывают мысль о том, что культ Победы в Великой Отечественной войне продуктивно осмыслять как проявление гражданской религии. Показано, что при сохранении советских форм празднования, в современных условиях меняется их содержание. Выявлено, что для коммеморативных практик Дня Победы в современной российской школе характерна перформативность, подмена идентификацией практик солидаризации, темпоральная инверсия.
The article deals with the peculiarities of the transformation of the May 9 practice of commemoration in modern Russian schools using the example of educational institutions of the Tambov and Lipetsk regions. Modern Russian experience is analyzed in the context of a comparative analysis of the peculiarities of the May 9 celebration in the Soviet school. The sources of the research were materials of social networks, websites of schools, as well as official and normative documentation of schools and departments of education. On the basis of the methodological ideas of E. Durkheim, R. Bella and J. Oliсk, the authors substantiate the idea that the cult of Victory in the Great Patriotic War is meaningfully considered as a manifestation of the civil religion. It is shown that with the preservation of Soviet forms of celebration, their content changes in modern conditions. It was revealed that for the commemorative practices of the Victory Day in the modern Russian school are performativity, substitution of the practice of solidarization with identification, temporal inversion.
ОТКРЫТКА РУБЕЖА XIX–XX вв.КАК СОЦИОКУЛЬТУРНЫЙ ФЕНОМЕН
Authors: Медяков А.С. 
Published: December 2024

В статье исследуется феномен почтовой открытки конца XIX – начала XX в. Появление и популярность открытки объясняются глубокими социальными изменениями, происходившими в это время. Проведен сравнительный анализ развития феномена открытки в разных странах. Показана роль приватизации производства открыток как важного условия их превращения в одного из главных выразителей интересов, вкусов и потребностей широких масс населения. Выделяются следующие социокультурные функции открыток: поддержание социальных связей, коммуникационная, информационная, репрезентативная, образовательно-педагогическая, идеологически-пропагандистская, экономическая и раз-влекательная. Делается вывод о специфике открытки как социокультурного феномена, заключающейся в ее бытовании на грани частной и публичной сфер.
The article investigates the phenomenon of postcards of the late 19th – early 20th centuries. The reasons for the appearance and popularity of the card are explained by the profound social changes that took place at that time. A comparative analysis of the development of the postcard phenomenon in different countries is carried out. The role of privatization of the production of postcards as an important condition for their transformation into one of the main spokesmen for the interests, tastes and needs of the broad masses of the population is shown. Sociocultural functions included communication, information, representational, educational, pedagogical, ideological, propagandistic, economic and entertainment functions. The conclusion is reached about the specifics of the postcard as a socio-cultural phenomenon, consisting in its being on the verge of a private and public sphere.
“ОБРАЗ ВРАГА” И АТМОСФЕРА“ХОЛОДНОГО ПРОТИВОСТОЯНИЯ”В ЗАРУБЕЖНОМ КИНЕМАТОГРАФЕ 1960–1970-х гг.
Authors: Юдин К.А. 
Published: December 2024

В статье на материалах зарубежных, преимущественно англо-американских, медиа-текстов 1960–1970-х гг., предпринимается попытка осуществить атрибуцию внутрен-ней и внешней угрозы, опасности и отчужденности как главных комплексных факторов, генерирующих атмосферу «холодного противостояния». В историко-философ-ском, культурологическо-киноведческом ракурсе анализируются основные типы и формы визуально-когнитивного проявления и интерпретации инаковости в кинематографической «гиперреальности». Автор приходит к выводу, что выведенные типы проявлений чуждости («чужой-в-себе», враг-лжегерой», «враг-прагматик») и их комбинации можно использовать для реконструкции национально-государственного взаимного восприятия и динамики коллективной памяти на современном этапе.
In an article based on the materials of foreign, mostly Anglo-American, media texts of the 1960s-1970s, an attempt is made to attribute the internal and external threat, danger and alienation as the main complex factors that generate an atmosphere of “cold confrontation”. The main types and forms of visual-cognitive manifestation and interpretation of otherness in the cinematic “hyper-reality” are analyzed in the historical-philosophical, cultural and cinematographic foreshortening. The author comes to the conclusion that the deduced conditional types of manifestations of alienness – the “alien-in-itself”, the “enemy-false-hero”, the “enemy-pragmatist» and their combinations can be used to reconstruct the national-state mutual perception and dynamics of collective memory in modern stage.