bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does eco‐innovation drive sales and technology investment? Focusing on eco‐label in Korea
Authors: Oh Myoungjin , Shin Jungwoo , Park Pil‐Ju , Kim Sunmee 
Published: August 2020

AbstractAs environmental problems worsen, eco‐innovation research has received increased attention. Korea is implementing an eco‐label policy to induce eco‐innovation. Eco‐labeling is a type of voluntary eco‐innovation. There are few empirical studies on the economic performance of eco‐labels in Korea and even fewer on the additional investment in the technology used for eco‐labeling. The present study quantitatively measured the effect of eco‐labels on additionally generated sales and research and development (R&D) investment through propensity score matching. The results revealed that eco‐labeling has a positive impact on sales over the following 2 years, which is the expiration date of certification; moreover, investment in R&D typically increased for 3 years before certification. Interestingly, no additional R&D investment was made after certification. This study is mainly a basis for the introduction of environmental certification to government policymakers or product strategists who have yet to implement a certification system.
A reliable septum exists between the lateral cord and medial and posterior cords in the costoclavicular region: Clinical and microanatomical considerations in brachial plexus anesthetic blockade
Authors: Monzó Enrique , Boezaart André P. , Tubbs Richard Shane , Sanromán‐Junquera Margarita , Nin Olga C. , Reina Miguel Angel 
Published: August 2020

AbstractBackground and ObjectivesThe ultrasound‐guided proximal infraclavicular costoclavicular block (PICB) appears popular but its results are inconsistent. We sought an accurate demonstration of septae formed between the brachial plexus cords.MethodsWe performed in‐plane, lateral‐to‐medial PICBs on 120 patients and recorded images. Once the most superficial lateral cord component was entered, a 0.4–0.6 mA current was applied to confirm needle placement; 5 ml of local anesthetic (LA) solution was then injected and its spread was observed and recorded. As the needle was advanced, the presence or absence of a hyperechoic linear structure was noted before the deeper compartment was reached, specifically looking for the possible displacement of such a septum.ResultsUpon initial scanning, a septum was observed in 67 of the 120 patients (46.2%). However, there was clear displacement of a linear septum between the lateral cord compartment and the medial and posterior cord compartments that prevented spread between the compartments in 94.16% of patients. Piercing the septum evoked motor responses from the medial or posterior cord. The same anatomical regions were studied microanatomically by analyzing cross‐sections obtained with the same approach angle as the ultrasound probe.ConclusionsIntraplexus fascial septae that bundled the medial and posterior cords into one compartment and separated them from the lateral cord were demonstrated and confirmed microanatomically. This suggests the need for two separate injections (or two separate catheter placements for continuous peripheral nerve blockade) into the superficial and deep compartments to ensure LA spread around all three cords of the brachial plexus at this level.
Virome assembly and annotation in brain tissue based on next‐generation sequencing
Authors: Yuan Zihao , Ye Xiaohua , Zhu Lisha , Zhang Ningyan , An Zhiqiang , Zheng W. Jim 
Published: August 2020

AbstractThe glioblastoma multiforme (GBM) is one of the deadliest tumors. It has been speculated that virus plays a role in GBM but the evidences are controversy. Published researches are mainly limited to studies on the presence of human cytomegalovirus (HCMV) in GBM. No comprehensive assessment of the brain virome, the collection of viral material in the brain, based on recently sequenced data has been performed. Here, we characterized the virome from 111 GBM samples and 57 normal brain samples from eight projects in the SRA database by a tested and comprehensive assembly approach. The annotation of the assembled contigs showed that most viral sequences in the brain belong to the viral family Retroviridae. In some GBM samples, we also detected full genome sequence of a novel picornavirus recently discovered in invertebrates. Unlike previous reports, our study did not detect herpes virus such as HCMV in GBM from the data we used. However, some contigs that cannot be annotated with any known genes exhibited antibody epitopes in their sequences. These findings provide several avenues for potential cancer therapy: the newly discovered picornavirus could be a starting point to engineer novel oncolytic virus; and the exhibited antibody epitopes could be a source to explore potential drug targets for immune cancer therapy. By characterizing the virosphere in GBM and normal brain at a global level, the results from this study strengthen the link between GBM and viral infection which warrants the further investigation.
Child Maltreatment Portrayed in Bangladeshi Newspapers
Authors: Atiqul Haque M. , Janson Staffan , Moniruzzaman Syed , Fazlur Rahman A. K. M. , Islam Syed Shariful , Mashreky Saidur Rahman , Eriksson Ulla‐Britt 
Published: August 2020

As in most low‐income countries, there is a lack of scientific information on the incidence and pattern of child maltreatment (CM) in Bangladesh. However, the role of the media to disclose CM and to develop public awareness in society is noteworthy. The present study assessed newspaper reports about CM by type and socio‐demographics of victims and perpetrators in Bangladesh. In total, 790 news articles were collected retrospectively from four Bengali‐ and two English‐language newspapers from October to December 2014. Among all reported incidents, almost half of the CM cases concerned alleged physical abuse (26%) and sexual abuse (22%). Neglect and emotional or psychological abuse received less coverage. Female children were to a high degree (90%) victims of sexual abuse. The main perpetrators were males, and they were often known to the victims. Approximately 32 per cent of the reported abuse cases resulted in death and were related to rape, family violence, administrative negligence, abduction and ransom demand. Some of these deaths were suicides. News stories concerning CM were often reported in an unethical way by identifying the victim and not respecting child rights. Further, the stories seldom discussed the individual or social consequences of CM, or how maltreatment could be prevented.‘The present study assessed newspaper reports about CM by type and socio‐demographics of victims and perpetrators in Bangladesh’Key Practitioner Messages

The main types of reported cases of CM in Bangladeshi print media are physical abuse and sexual abuse, and there is a high proportion of fatal consequences.
The perpetrators are often known to the victims.
The identity of the victim is frequently reported, potentially putting the child at risk and violating child rights.
Bangladeshi print media seldom discusses individual or societal consequences of CM, or how it could be prevented.
Rice phenolic compounds and their response to variability in growing conditions
Authors: Rao Shiwangni , Santhakumar Abishek B. , Chinkwo Kenneth , Snell Peter , Oli Prakash , Blanchard Christopher L. 
Published: August 2020

AbstractBackground and objectivesPhenolic compounds present in rice have substantial antioxidant activity, which has contributed to its potential as a functional food. However, a gap in knowledge exists on how phenolic compounds in rice respond to variation in growing conditions, and the subsequent impact on their antioxidant activity. The current study investigated wholegrain pigmented rice varieties Yunlu29 and Purple, and a nonpigmented variety, Reiziq cultivated in Queensland (QLD) and New South Wales (NSW), Australia. The Queensland location in Mackay had a tropical climate and loamy soil, while the NSW location in Yanco had a temperate climate with clay soil.FindingsPigmented rice, Yunlu29 and Purple cultivated in Mackay (QLD), exhibited significantly higher total phenolic contents and increased levels of anthocyanin, proanthocyanidin, and antioxidant activity in comparison with Yanco (NSW)‐grown samples. Phenolic compounds including procyanidins and anthocyanidins, cyanidin 3‐glucoside and peonidin 3‐glucoside, were significantly impacted by growing location when compared to other phenolic compounds. For some compounds like vanillic acid, luteolin 4'‐methyl ether 7‐(4G‐rhamnosylneohesperidoside), and proanthocyanidin derivative, the impact of the cultivation environment varied among the three rice varieties, highlighting the influence of both genetics and environment.ConclusionsCultivation location was found to have a significant impact on phenolic composition and antioxidant activity. It was also observed that phenolic compounds affected by growing location conditions also significantly contributed to antioxidant activity.Significance and noveltyThese findings contribute to an understanding of how phenolic compounds respond to the variation in the cultivation environment in Australia, which is essential for breeding high‐value rice varieties with specific phenolic compositions.
Sublingual dermoid cyst in an infant: A case report and review of the literature
Authors: Vélez‐Cruz Madeleine Edith , Gómez‐Clavel José Francisco , Licéaga‐Escalera Carlos Juan , Montoya Pérez Luis Alberto , Trujillo Fandiño Juan José , Trejo Iriarte Cynthia Georgina , Ramírez‐Cano Maria Fernanda , García‐Muñoz Alejandro 
Published: August 2020

AbstractDermoid cysts usually occur later in the second decade of life; we present the approach of an unusual case of an infant who presented a cyst within the oral cavity, which is important because it can be confused with other pathologies.
Retrieval of fragmented peripherally inserted central catheter (PICC) with a double transfemoral access technique
Authors: Papa Alfonso , Tammaro Dario , Monda Vittorio 
Published: August 2020

AbstractRetrieval of central venous catheters fragments often puts us in front of different situations. Having more techniques available for strategic planning of the procedure is important. The authors propose the simultaneous use of two different approaches for the recovery of a CVC fragment from the pulmonary artery.
Electrochemical Copolymerization of Isoindigo‐Based Donor‐Acceptor Polymers with Intrinsically Enhanced Conductivity and Near‐Infrared‐II Activity
Authors: Sparks Nicholas E. , Ranathunge Tharindu A. , Attanayake Nuwan H. , Brodgon Phillip , Delcamp Jared H. , Rajapakse R. M. Gamini , Watkins Davita L. 
Published: August 2020

AbstractDonor‐acceptor (D−A) polymers have excellent electronic and optical properties that allow for their use in multiple areas of research, ranging from field‐effect transistors to biosensing. However, traditional chemical polymerization strategies to form D−A polymers often require extensive purification and generate large amounts of waste. Electro‐copolymerization of complex isoindigo‐based copolymers is explored as a way to overcome traditional synthetic challenges. Herein, the electropolymerization and characterization of four isoindigo‐based D−A copolymers are studied with: II‐EDOT‐T3, II‐Thio‐T3, II‐Thio‐T3‐TTDT2, and II‐EDOT‐T3‐TTDT2. Scanning electron microscopy (SEM) and energy dispersive X‐ray (EDX) analysis are used to confirm the composition of the polymers. Electrochemical impedance measurements show electron‐transport resistance (Re) values as low as 74.7 Ω at selected potentials, indicating that highly conductive copolymers are present. These p‐doped polymers exhibit absorption bands within the near‐infrared region (NIR) with optical band gaps as low as 0.790 eV. Results confirm the electro‐synthesized D−A copolymers exhibit excellent optical properties in the solid state and enhanced conductivity relative to conventional polymers; thus, affording materials with uses in a broad spectrum of applications.
Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
Authors: Couto Marcos , Alamón Catalina , Nievas Susana , Perona Marina , Dagrosa María Alejandra , Teixidor Francesc , Cabral Pablo , Viñas Clara , Cerecetto Hugo 
Published: August 2020

AbstractAbout 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced chemotherapy drugs or radiation therapy or, ideally, two‐in‐one hybrid systems should be implemented. Tyrosine kinase receptors–inhibitors and boron neutron capture therapy (BNCT), together, could provide a therapeutic strategy. In this work, sunitinib decorated‐carborane hybrids were prepared and biologically evaluated identifying excellent antitumoral‐ and BNCT‐agents. One of the selected hybrids was studied against glioma‐cells and found to be 4 times more cytotoxic than sunitinib and 1.7 times more effective than 10B‐boronophenylalanine fructose complex when the cells were irradiated with neutrons.
Attempts to Synthesize a Thiirane, Selenirane, and Thiirene by Dealkylation of Chalcogeniranium and Thiirenium Salts
Authors: Poleschner Helmut , Seppelt Konrad 
Published: August 2020

AbstractThiiranium salts [Ad2SR]+X− (5, 8, 9, 11, 12; X−=Tf2N− (Tf=CF3SO2), SbCl6−) and seleniranium salts [Ad2SeR]+X− (14, 16, 17, 23–25; X−=Tf2N−, BF4−, CHB11Cl11−, SbCl6−) are synthesized from strained alkene bis(adamantylidene) (1). The disulfides and the diselenides (Me3SiCH2CH2E)2 (4, 13), (tBuMe2SiCH2CH2E)2 (7, 22), and (NCCH2CH2E)2 (10, 15; E=S, Se) have been used. The thiirenium salts [tBu2C2SR]+X− (34) and [Ad2C2SR]+X− (35, 36) are prepared from the bis‐tert‐butylacetylene (2) and bis‐adamantyl‐acetylene (3) with R=Me3SiCH2CH2 and tBuMe2SiCH2CH2. Attempts to cleave off the groups Me3SiCH2CH2, tBuMe2SiCH2CH2, and NCCH2CH2 resulted in thiiranes 27, 30. No selenirane Ad2Se (33) is formed from seleniranium salts, instead cleavage to the alkene (1) and diselenide (13, 15) occurs. The thiirenium salt [Ad2C2SCH2CH2SiMe3]+Tf2N− (35) does not yield the thiirene Ad2C2S (37), the three‐membered ring is cleaved, forming the alkyne (3) and disulfide (4). All compounds are characterized by ESI mass spectra, NMR spectra, and by quantum chemical calculations. Crystal structures of the salts 8, 12, 25, 17, 26, 36 and the thiiranes 27, 30 are presented.
Spectral study on inclusion interaction and enantiorecognition of 2‐aryl carboxylic acids with hydroxypropyl‐β‐cyclodextrin
Authors: Jin Yang , Sun Wenyu , Lv Huawei , Tong Shengqiang 
Published: August 2020

AbstractThe inclusion interaction between hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) and 21 2‐aryl carboxylic acids was investigated by UV (ultraviolet) spectrophotometer. The inclusion constant of each 2‐aryl carboxylic acids with HP‐β‐CD was determined by Benesi–Hildebrand's equation. According to our previous work, it was found that a high inclusion constant for inclusion complex formed by a racemate and cyclodextrin was always observed with the fact that a high enantioseparation factor was achieved for the racemate in enantioseparation by liquid–liquid chromatography, which suggested that high binding combination between racemate and cyclodextrin is very important for a successful enantioseparation in enantioselective liquid–liquid extraction. Among all the studied subjects, mandelic acid enantiomer, 2,3‐diphenylpropionic acid enantiomer, and naproxen enantiomer were selected for the further study. The inclusion constants of enantiomers of these three subjects were determined by UV spectra, which indicated that a necessary difference in inclusion constants between enantiomer and cyclodextrin was also essential. It was found in UV spectra that the absorbance of the analytes with the addition of cyclodextrin would increase or decrease, which was determined by the type of electron excitation. The conformation changes of small molecules can lead to the changes of chromophore valence electron clouds distribution, causing the HOMO‐LUMO energy difference decreased. Thus, a red shift of the wavelength of the maximum absorption was produced indicating that the possibility of the molecular interaction of enantiomers with HP‐β‐CD exists.
Mean arterial pressure is associated with the neurological function in patients who survived after cardiopulmonary resuscitation: A retrospective cohort study
Authors: Ai Hai‐bo , Jiang En‐li , Yu Ji‐hua , Xiong Lin‐bo , Yang Qi , Jin Qi‐zu , Gong Wen‐yan , Chen Shuai , Zhang Hong 
Published: August 2020

AbstractBackgroundAbout 18% to 40% of the survivors have moderate to severe neurological dysfunction. At present, studies on mean arterial pressure (MAP) and neurological function of patients survived after cardiopulmonary resuscitation (CPR) are limited and conflicted.HypothesisThe higher the MAP of the patient who survived after CPR, the better the neurological function.MethodA retrospective cohort study was conducted to detect the relationship between MAP and the neurological function of patients who survived after CPR by univariate analysis, multivariate regression analysis, and subgroup analysis.ResultsFrom January 2007 to December 2015, a total of 290 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that MAP was associated with the neurological function of patients who survived after CPR; its OR value was 1.03 (1.01, 1.04). The multi‐factor regression analysis also showed that MAP was associated with the neurological function of patients survived after CPR in the four models, the adjusted OR value of the four models were 1.021 (1.008, 1.035); 1.028 (1.013, 1.043); 1.027 (1.012, 1.043); and 1.029 (1.014, 1.044), respectively. The subgroups analyses showed that when 65 mm Hg ≤ MAP<100 mm Hg and when patients with targeted temperature management or without extracorporeal membrane oxygenation, with the increase of MAP, the better neurological function of patients survived after CPR.ConclusionThis study found that the higher MAP, the better the neurological function of patients who survived after CPR. At the same time, the maintenance of MAP at 65 to 100 mm Hg would improve the neurological function of patients who survived after CPR.
Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors
Authors: Clima Lilia , Craciun Bogdan Florin , Angeli Andrea , Petreni Andrea , Bonardi Alessandro , Nocentini Alessio , Carta Fabrizio , Gratteri Paola , Pinteala Mariana , Supuran Claudiu T. 
Published: August 2020

AbstractWe report novel molecules incorporating the nontoxic squalene scaffold and different carbonic anhydrase inhibitors (CAIs). Potent inhibitory action, in the low‐nanomolar range, was detected against isoforms hCA II for sulfonamide derivatives, which proved to be selective against this isoform over the tumor‐associate hCA IX and XII isoforms. On the other hand, coumarin derivatives showed weak potency but high selectivity against the tumor‐associated isoform CA IX. These compounds are interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved. In addition, an in silico study of inhibitor‐bound hCA II revealed extensive interactions with the hydrophobic pocket of the active site and provided molecular insights into the binding properties of these new inhibitors.
Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer
Authors: Barcherini Valentina , Almeida Joana , Lopes Elizabeth A. , Wang Mi , Magalhães e Silva Diogo , Mori Mattia , Wang Shaomeng , Saraiva Lucília , Santos Maria M. M. 
Published: August 2020

AbstractTo search for novel p53 activators, four series of novel (S)‐ and (R)‐tryptophanol‐derived oxazoloisoindolinones were synthesized in a straightforward manner and their antiproliferative activity was evaluated in the human colorectal cancer HCT116 cell line. Structural optimization of the hit compound SLMP53‐1 led to the identification of a (R)‐tryptophanol‐derived isoindolinone that was found to be six‐fold more active, with increased selectivity for HCT116 cells with p53 and with low toxicity in normal cells. Binding studies with MDM2 showed that the antiproliferative activity of tryptophanol‐derived isoindolinones does not involve inhibition of the main negative regulator of the p53 protein. Molecular docking simulations showed that although these molecules establish hydrophobic interactions with MDM2, they do not possess the required features to bind MDM2.
Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances
Authors: Mastrangelopoulou Maria , Grigalavicius Mantas , Raabe Tine H. , Skarpen Ellen , Juzenas Petras , Peng Qian , Berg Kristian , Theodossiou Theodossis A. 
Published: August 2020

AbstractBackgroundPhotodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies. 5‐aminolevulinic acid (5‐ALA)‐PDT is of particular interest, as it uses the photosensitiser PpIX, naturally produced in the heme pathway, following 5‐ALA administration. Even though 5‐ALA‐PDT shows high specificity to cancers, differences in treatment outcomes call for predictive biomarkers to better stratify patients and to also diversify 5‐ALA‐PDT based on each cancer's phenotypic and genotypic individualities.AimsThe present study seeks to highlight key biomarkers that may predict treatment outcome and simultaneously be exploited to overcome cancer‐specific resistances to 5‐ALA‐PDT.Methods and ResultsWe submitted two glioblastoma (T98G and U87) and three breast cancer (MCF7, MDA‐MB‐231, and T47D) cell lines to 5‐ALA‐PDT. Glioblastoma cells were the most resilient to 5‐ALA‐PDT, while intracellular production of 5‐ALA‐derived protoporphyrin IX (PpIX) could not account for the recorded PDT responses.We identified the levels of expression of ABCG2 transporters, ferrochelatase (FECH), and heme oxygenase (HO‐1) as predictive biomarkers for 5‐ALA‐PDT. GPX4 and GSTP1 expression vs intracellular glutathione (GSH) levels also showed potential as PDT biomarkers.For T98G cells, inhibition of ABCG2, FECH, HO‐1, and/or intracellular GSH depletion led to profound PDT enhancement. Inhibition of ABCG2 in U87 cells was the only synergistic adjuvant to 5‐ALA‐PDT, rendering the otherwise resistant cell line fully responsive to 5‐ALA‐PDT.ABCG2 or FECH inhibition significantly enhanced 5‐ALA‐PDT‐induced MCF7 cytotoxicity, while for MDA‐MB‐231, ABCG2 inhibition and intracellular GSH depletion conferred profound synergies. FECH inhibition was the only synergism to ALA‐PDT for the most susceptible among the cell lines, T47D cells.ConclusionThis study demonstrates the heterogeneity in the cellular response to 5‐ALA‐PDT and identifies biomarkers that may be used to predict treatment outcome. The study also provides preliminary findings on the potential of inhibiting specific molecular targets to overcome inherent resistances to 5‐ALA‐PDT.