bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sodium chloride on the gene expression profile of periodontal ligament fibroblasts during tensile strain
Authors: Schröder Agnes , Gubernator Joshua , Nazet Ute , Spanier Gerrit , Jantsch Jonathan , Proff Peter , Kirschneck Christian 
Published: July 2020

AbstractPurposeDuring orthodontic tooth movement, pressure and tension zones develop in the periodontal ligament, and periodontal ligament fibroblasts (PDLF) become exposed to mechanical strain. Enhanced salt (NaCl) concentrations are known to modulate responses of PDLF and immune cells to different stimuli like mechanical strain. Here, we investigated the impact of tensile strain on the gene expression profile of PDLF under normal (NS) and high salt (HS) conditions.MethodsAfter preincubation under NS or HS (+40 mM NaCl in medium) conditions for 24 h, PDLF were stretched 16% for 48 h using custom-made spherical cap silicone stamps using an established and published setup. After determination of cell number and cytotoxicity, we analyzed expression of genes involved in extracellular matrix reorganization, angiogenesis, bone remodeling, and inflammation by quantitative real-time polymerase chain reaction (RT-qPCR).ResultsTensile strain did not affect the expression of genes involved in angiogenesis or extracellular matrix reorganization by PDLF, which however modulate inflammatory responses and bone remodeling in reaction to 16% static tensile strain. Salt (NaCl) treatment triggered enhanced extracellular matrix formation, expression of cyclooxygenase 2 and bone metabolism in PDLF during tensile strain.ConclusionsSalt (NaCl) consumption may influence orthodontic tooth movement and periodontal bone loss via modulation of extracellular matrix and bone metabolism. Excessive salt intake during orthodontic therapy may cause adverse effects regarding periodontal inflammation and bone resorption.
Akute Appendizitis nach Knochenentnahme am rechten Beckenkamm – erschwerte Differenzialdiagnostik
Authors: Förch S. , Ritter B. , Mayr E. 
Published: July 2020

Zusammenfassung
Zur knöchernen Defektauffüllung wird regelhaft Knochen vom vorderen Beckenkamm entnommen. Typische Komplikationen sind postoperatives Hämatom, Nervenverletzungen, Infektionen oder Schmerzen an der Entnahmestelle. Wir beschreiben einen Fall, in dem es nach Knochenentnahme am rechten Beckenkamm bei einem jungen Patienten als Koinzidenz zu einer akuten Appendizitis kam. Durch die durchgeführte Knochenentnahme kam es zu einer erschwerten Diagnosestellung, die nur durch eine differenzierte klinische Untersuchung und daraufhin eingeleitete laborchemische und apparative Diagnostik möglich war.
Cartan subalgebras and the UCT problem, II
Authors: Barlak Selçuk , Li Xin 
Published: July 2020

AbstractWe study the connection between the UCT problem and Cartan subalgebras in C*-algebras. The UCT problem asks whether every separable nuclear C*-algebra satisfies the UCT, i.e., a noncommutative analogue of the classical universal coefficient theorem from algebraic topology. This UCT problem is one of the remaining major open questions in the structure and classification theory of simple nuclear C*-algebras. Since the class of separable nuclear C*-algebras is closed under crossed products by finite groups, it is a natural and important task to understand the behaviour of the UCT under such crossed products. We make a contribution towards a better understanding by showing that for certain approximately inner actions of finite cyclic groups on UCT Kirchberg algebras, the crossed products satisfy the UCT if and only if we can find Cartan subalgebras which are invariant under the actions of our finite cyclic groups. We also show that the class of actions we are able to treat is big enough to characterize the UCT problem, in the sense that every such action (even on a particular Kirchberg algebra, namely the Cuntz algebra$$\mathcal O_2$$O2) leads to a crossed product satisfying the UCT if and only if every separable nuclear C*-algebra satisfies the UCT. Our results rely on a new construction of Cartan subalgebras in certain inductive limit C*-algebras. This new tool turns out to be of independent interest. For instance, among other things, the second author has used it to construct Cartan subalgebras in all classifiable unital stably finite C*-algebras.
Asymptotic Solution of a Boundary Value Problem for a Spring–Mass Model of Legged Locomotion
Authors: Okrasińska-Płociniczak Hanna , Płociniczak Łukasz 
Published: July 2020

AbstractRunning is the basic mode of fast locomotion for legged animals. One of the most successful mathematical descriptions of this gait is the so-called spring–mass model constructed upon an inverted elastic pendulum. In the description of the grounded phase of the step, an interesting boundary value problem arises where one has to determine the leg stiffness. In this paper, we find asymptotic expansions of the stiffness. These are conducted perturbatively: once with respect to small angles of attack, and once for large velocities. Our findings are in agreement with previous results and numerical simulations. In particular, we show that the leg stiffness is inversely proportional to the square of the attack angle for its small values, and proportional to the velocity for large speeds. We give exact asymptotic formulas to several orders and conclude the paper with a numerical verification.
PTV measurements of oscillating grid turbulence in water and polymer solutions
Authors: Lacassagne Tom , Vatteville Judith , Degouet Cedric , El Hajem Mahmoud , Simoëns Serge 
Published: July 2020

Abstract
Particle Tracking Velocimetry (PTV) is applied to measure the flow in an oscillating grid stirred tank filled with either water or shear thinning dilute polymer solutions (DPS) of Xanthan Gum (XG). There are many interests of studying turbulence in such complex non-Newtonian fluids (e.g. in the pharmaceutical, cosmetic, or food industry), and grid stirred tanks are commonly used for fundamental studies of turbulence in Newtonian fluids. Yet the case of oscillating grid flows in shear thinning solutions has been addressed recently by Lacassagne et al. (Exp Fluids 61(1):15, Phys Fluids 31(8):083102, 2019a, b), with only a single two dimensional (2D) Particle Image Velocimetry (PIV) characterization of mean flow and turbulence properties in the central vertical plane of the tank. Here, PTV data processed by the Shake The Box algorithm allows for the time resolved, three dimensional (3D) 3 components (3C) measurement of Lagrangian velocities for a large number of tracked particles in a central volume of interest of the tank. The possibility of projecting this Lagrangian information on an Eulerian grid is explored, and projected Eulerian results are compared with 2D PIV data from the previous work. Even if the mean flow is difficult to reproduce at the lowest polymer concentrations, a good agreement is found between measured turbulent decay laws, thus endorsing the use of this 3D-PTV metrology for the study of oscillating grid turbulence in DPS. The many possibilities of further analysis offered by the 3D3C nature of the data, either in the original Lagrangian form or in the projected Eulerian one, are finally discussed.

Graphic Abstract
Study of disturbance wave development in downwards annular flows with a moving frame-of-reference brightness-based laser-induced fluorescence method
Authors: An Jae Sik , Cherdantsev Andrey V. , Zadrazil Ivan , Markides Christos N. 
Published: July 2020

Abstract
A novel moving frame-of-reference brightness-based laser-induced fluorescence (MFoR-BBLIF) method was developed and demonstrated in downwards co-current air–water annular flows. The method was applied to study the downstream development of individual disturbance waves in flows over a range of conditions (ReL = 276–1321, ReG = 39,500–79,000). In this method, the optical measurement system, and hence, the region of interrogation (ROI) was translated physically along the length of the test-section with a velocity close to that of individual disturbance waves to obtain the velocities of individual disturbance-waves as a function of downstream distance from the inlet. It was found that the velocities of individual disturbance waves increase with both downstream distance and gas–liquid flow conditions. In addition, the variation in the wave velocities was more significant at higher gas and liquid Reynolds numbers. The approach can be integrated with many other contactless measurement methods, and can also be used over a range of translation speeds (not necessarily in a “Lagrangian” manner) to study the evolution of important advecting flow phenomena.

Graphic abstract
OLBVH: octree linear bounding volume hierarchy for volumetric meshes
Authors: Ströter Daniel , Mueller-Roemer Johannes S. , Stork André , Fellner Dieter W. 
Published: July 2020

AbstractWe present a novel bounding volume hierarchy for GPU-accelerated direct volume rendering (DVR) as well as volumetric mesh slicing and inside-outside intersection testing. Our novel octree-based data structure is laid out linearly in memory using space filling Morton curves. As our new data structure results in tightly fitting bounding volumes, boundary markers can be associated with nodes in the hierarchy. These markers can be used to speed up all three use cases that we examine. In addition, our data structure is memory-efficient, reducing memory consumption by up to 75%. Tree depth and memory consumption can be controlled using a parameterized heuristic during construction. This allows for significantly shorter construction times compared to the state of the art. For GPU-accelerated DVR, we achieve performance gain of 8.4$$\times $$
×
–13$$\times $$
×
. For 3D printing, we present an efficient conservative slicing method that results in a 3$$\times $$
×
–25$$\times $$
×
speedup when using our data structure. Furthermore, we improve volumetric mesh intersection testing speed by 5$$\times $$
×
–52$$\times $$
×
.
Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity
Authors: Fikenzer Sven , Uhe T. , Lavall D. , Rudolph U. , Falz R. , Busse M. , Hepp P. , Laufs U. 
Published: July 2020

Abstract
Background
Due to the SARS-CoV2 pandemic, medical face masks are widely recommended for a large number of individuals and long durations. The effect of wearing a surgical and a FFP2/N95 face mask on cardiopulmonary exercise capacity has not been systematically reported.

Methods
This prospective cross-over study quantitated the effects of wearing no mask (nm), a surgical mask (sm) and a FFP2/N95 mask (ffpm) in 12 healthy males (age 38.1 ± 6.2 years, BMI 24.5 ± 2.0 kg/m2). The 36 tests were performed in randomized order. The cardiopulmonary and metabolic responses were monitored by ergo-spirometry and impedance cardiography. Ten domains of comfort/discomfort of wearing a mask were assessed by questionnaire.

Results
The pulmonary function parameters were significantly lower with mask (forced expiratory volume: 5.6 ± 1.0 vs 5.3 ± 0.8 vs 6.1 ± 1.0 l/s with sm, ffpm and nm, respectively; p = 0.001; peak expiratory flow: 8.7 ± 1.4 vs 7.5 ± 1.1 vs 9.7 ± 1.6 l/s; p < 0.001). The maximum power was 269 ± 45, 263 ± 42 and 277 ± 46 W with sm, ffpm and nm, respectively; p = 0.002; the ventilation was significantly reduced with both face masks (131 ± 28 vs 114 ± 23 vs 99 ± 19 l/m; p < 0.001). Peak blood lactate response was reduced with mask. Cardiac output was similar with and without mask. Participants reported consistent and marked discomfort wearing the masks, especially ffpm.

Conclusion
Ventilation, cardiopulmonary exercise capacity and comfort are reduced by surgical masks and highly impaired by FFP2/N95 face masks in healthy individuals. These data are important for recommendations on wearing face masks at work or during physical exercise.
Intra- and intermuscular variations of postmortem protein degradation for PMI estimation
Authors: Pittner Stefan , Gotsmy Walther , Zissler Angela , Ehrenfellner Bianca , Baumgartner Dominik , Schrüfer Anna , Steinbacher Peter , Monticelli Fabio 
Published: July 2020

AbstractIn recent years, protein decomposition has become of increasing interest for the use in forensic estimation of the postmortem interval (PMI). Especially skeletal muscle tissue has proven to be a prime target tissue, among other reasons, due to its large abundance in the human body. In this regard, it is important to know whether there are any intra- and intermuscular differences in the behavior of protein degradation. Thus, samples from different locations within several skeletal muscles as well as from cardiac and smooth muscle tissue samples were collected from three autopsy cases with varying degree of decomposition. Samples were analyzed by SDS-PAGE and Western blotting and compared for protein degradation patterns. Intramuscular variations turned out to be minimal and without major influence for the use of the method. Observed intermuscular differences provide possibilities for future improvement of the precision and temporal application range. The results of this study show the strengths and current limitations of protein degradation-based PMI estimation and provide a deeper understanding of intraindividual postmortem protein degradation processes.
Finding Needles in a Haystack
Authors: Kurusa Árpád 
Published: July 2020

AbstractConvex polygons are distinguishable among the piecewise $$C^\infty $$

C
∞

convex domains by comparing their visual angle functions on any surrounding circle. This is a consequence of our main result, that every segment in a $$C^\infty $$

C
∞

multicurve can be reconstructed from the masking function of the multicurve given on any surrounding circle.
Perioperative and oncological outcomes following minimally invasive versus open pancreaticoduodenectomy for pancreatic duct adenocarcinoma
Authors: Sun Rui , Yu Jiawen , Zhang Yifan , Liang Zhika , Han Xianlin 
Published: July 2020

Abstract
Background
The outcomes of minimally invasive pancreaticoduodenectomy have not been adequately compared with those of open pancreaticoduodenectomy in patients with pancreatic ductal adenocarcinoma. We performed a meta‐analysis to compare the perioperative and oncological outcomes of these two pancreaticoduodenectomy procedures specifically in patients with pancreatic ductal adenocarcinoma.

Methods
Before this study was initiated, a specific protocol was designed and has been registered in PROSEPRO (ID: CRD42020149438). Using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, PubMed, EMBASE, Web of Science, Cochrane Central Register, and ClinicalTrials.gov databases were systematically searched for studies published between January 1994 and October 2019. Overall survival, disease-free survival, and time to commencing adjuvant chemotherapy were the primary endpoint measurements, whereas perioperative and short-term outcomes were the secondary endpoints.

Results
The final analysis included 9 retrospective cohorts comprising 11,242 patients (1377 who underwent minimally invasive pancreaticoduodenectomy and 9865 who underwent open pancreaticoduodenectomy). There were no significant differences in the patients’ overall survival, operative time, postoperative complications, 30-day mortality, rate of vein resection, number of harvested lymph nodes, or rate of positive lymph nodes between the two approaches. However, disease-free survival, time to starting adjuvant chemotherapy, length of hospital stay, and rate of negative margins in patients who underwent minimally invasive pancreaticoduodenectomy showed improvements relative to those in patients who underwent open surgery.

Conclusions
Minimally invasive pancreaticoduodenectomy provides similar or even improved perioperative, short-term, and long-term oncological outcomes when compared with open pancreaticoduodenectomy for patients with pancreatic ductal adenocarcinoma.
One-session laparoscopic management of Mirizzi syndrome: feasible and safe in specialist units
Authors: Nassar Ahmad H. M. , Nassar Mahmoud K. , Gil Ines C. , Ng Hwei J. , Yehia Ahmad M. 
Published: July 2020

Abstract
Background
To evaluate the laparoscopic management of Mirizzi syndrome, seldom diagnosed preoperatively causing difficulty when performing cholecystectomy and increasing complication risks.

Methods
Analysis of a prospective single-surgeon database of 5700 laparoscopic cholecystectomies found 58 Mirizzi syndrome cases. They were managed with an intention to treat during the index admission according to protocol of single-session management of bile duct stones.

Results
38/58 patients were females (65.5%). The median age was 55 years. 53 cases were emergency admissions. 34 cases (58.6%) only had ultrasound scanning. Operative difficulty was Grade IV in 34 cases (58.6%) and Grade V in 20 (34.5%) (Nassar Scale). There were 33 Mirizzi Type IA, 7 Type IB, 16 Type II and one each of Type III and Type IV. Bile duct exploration was performed in 94.8% through choledochotomy/ transfistula in 58.6% or transcystic in 36.2%. Four cases required conversion to open. Postoperative morbidity occurred in 29%. Two 30-day mortalities occurred from pneumonia in two elderly patients who were late referrals.

Conclusion
Although the utilization of the laparoscopic approach in managing bile duct stones is not currently widely practiced it was safer in this series than in reported series of open surgery in Mirizzi Syndrome. The optimal approach to Mirizzi Type II is via cholecystocholedochal fistula to explore the bile duct then drain with T-tube through the fistula. It is unnecessary to perform bilioenteric bypass in majority of cases, reducing the morbidity and mortality.
Memetic algorithms for training feedforward neural networks: an approach based on gravitational search algorithm
Authors: García-Ródenas Ricardo , Linares Luis Jimenez , López-Gómez Julio Alberto 
Published: July 2020

AbstractThe backpropagation (BP) algorithm is a gradient-based algorithm used for training a feedforward neural network (FNN). Despite the fact that BP is still used today when FNNs are trained, it has some disadvantages, including the following: (i) it fails when non-differentiable functions are addressed, (ii) it can become trapped in local minima, and (iii) it has slow convergence. In order to solve some of these problems, metaheuristic algorithms have been used to train FNN. Although they have good exploration skills, they are not as good as gradient-based algorithms at exploitation tasks. The main contribution of this article lies in its application of novel memetic approaches based on the Gravitational Search Algorithm (GSA) and Chaotic Gravitational Search Algorithm (CGSA) algorithms, called respectively Memetic Gravitational Search Algorithm (MGSA) and Memetic Chaotic Gravitational Search Algorithm (MCGSA), to train FNNs in three classical benchmark problems: the XOR problem, the approximation of a continuous function, and classification tasks. The results show that both approaches constitute suitable alternatives for training FNNs, even improving on the performance of other state-of-the-art metaheuristic algorithms such as ParticleSwarm Optimization (PSO), the Genetic Algorithm (GA), the Adaptive Differential Evolution algorithm with Repaired crossover rate (Rcr-JADE), and the Covariance matrix learning and Bimodal distribution parameter setting Differential Evolution (COBIDE) algorithm. Swarm optimization, the genetic algorithm, the adaptive differential evolution algorithm with repaired crossover rate, and the covariance matrix learning and bimodal distribution parameter setting differential evolution algorithm.
Hans Peter Cornelius (1888–1950): a perfect mapping geologist and scientific explorer of the Alps
Authors: Dullo Wolf-Christian , Pfaffl Fritz A. 
Published: July 2020

AbstractHans Peter Cornelius was a squeamishly and accurately mapping field geologist with an eye for the finest detail as well as for the large-scale architectural structure of mountain ranges. His excellent work concerned the Rhaetian and Allgäu Alps, South Tyrol, the Valais and Ticino in Switzerland and many regions in Austria. His publications on the Err-Julier Group, the Insubric Line, the Großglockner Group, the Rax-Schneeberg Group, the alpine Grauwackenzone, and the Penninic series of the Western and Eastern Alps became particularly important.
CoVeriTest: interleaving value and predicate analysis for test-case generation
Authors: Jakobs Marie-Christine 
Published: July 2020

AbstractVerification techniques are well-suited for automatic test-case generation. They basically need to check the reachability of every test goal and generate test cases for all reachable goals. This is also the basic idea of our CoVeriTest submission. However, the set of test goals is not fixed in CoVeriTest , instead we can configure the set of test goals. For Test-Comp’19, we support the set of all ___ calls as well as the set of all branches. Thus, we can deal with the two test specifications considered in Test-Comp’19. Since the tasks in Test-Comp are diverse and verification techniques have different strengths and weaknesses, we also do not stick to a single verification technique, but use a hybrid approach that combines multiple techniques. More concrete, CoVeriTest interleaves different verification techniques and allows to configure the cooperation (i.e., information exchange and time limits). To choose from a large set of verification techniques, CoVeriTest is integrated into the analysis framework CPAchecker. For the competition, we interleave CPAchecker’s value and predicate analysis and let both analyses resume their analysis performed in the previous iteration.
Cost and effects of integrated care: a systematic literature review and meta-analysis
Authors: Rocks Stephen , Berntson Daniela , Gil-Salmerón Alejandro , Kadu Mudathira , Ehrenberg Nieves , Stein Viktoria , Tsiachristas Apostolos 
Published: July 2020

Abstract
Background
Health and care services are becoming increasingly strained and healthcare authorities worldwide are investing in integrated care in the hope of delivering higher-quality services while containing costs. The cost-effectiveness of integrated care, however, remains unclear. This systematic review and meta-analysis aims to appraise current economic evaluations of integrated care and assesses the impact on outcomes and costs.

Methods
CINAHL, DARE, EMBASE, Medline/PubMed, NHS EED, OECD Library, Scopus, Web of Science, and WHOLIS databases from inception to 31 December 2019 were searched to identify studies assessing the cost-effectiveness of integrated care. Study quality was assessed using an adapted CHEERS checklist and used as weight in a random-effects meta-analysis to estimate mean cost and mean outcomes of integrated care.

Results
Selected studies achieved a relatively low average quality score of 65.0% (± 18.7%). Overall meta-analyses from 34 studies showed a significant decrease in costs (0.94; CI 0.90–0.99) and a statistically significant improvement in outcomes (1.06; CI 1.05–1.08) associated with integrated care compared to the control. There is substantial heterogeneity in both costs and outcomes across subgroups. Results were significant in studies lasting over 12 months (12 studies), with both a decrease in cost (0.87; CI 0.80–0.94) and improvement in outcomes (1.15; 95% CI 1.11–1.18) for integrated care interventions; whereas, these associations were not significant in studies with follow-up less than a year.

Conclusion
Our findings suggest that integrated care is likely to reduce cost and improve outcome. However, existing evidence varies largely and is of moderate quality. Future economic evaluation should target methodological issues to aid policy decisions with more robust evidence on the cost-effectiveness of integrated care.