bluuebunny/crossref_metadata_2025_split huggingface dataset:
Housing microfinance, saving and credit cooperatives, and community development in low-income settings in Mexico
Authors: Escobar Luisa , Grubbauer Monika 
Published: October 2020

AbstractHousing microfinance schemes for self-organized housing have been incorporated into Mexican housing policies since 2007. This is the result of World Bank loans to Mexico but also of housing activists who for decades have advocated for the development of financial instruments to support the ‘social production of housing’—a concept defined by them as a type of housing production geared to meet families’ shelter needs rather than to enhance capital accumulation. While these World Bank housing loans were mainly oriented to strengthen the housing finance sector, the housing activists pushed for the inclusion of saving and credit cooperatives as housing microfinance providers. These cooperatives seek to promote at the local level, alternative development projects built on solidarity economy principles. Taking inspiration from critical literature on the co-optation of progressive actors by international financial institutions we highlight the activists’ agency and examine their role at the community level. We argue that processes of co-optation pushed by international financial institutions can always be contested and negotiated at a local level. We propose that, in this case, the engagement of progressive actors such as saving and credit cooperatives working according to principles of the solidarity economy could open political opportunities to subvert financial rationalities inscribed in the housing finance schemes of the World Bank.
Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study
Authors: Kobylecki Camilla J , Nordestgaard Børge G , Afzal Shoaib 
Published: October 2020

Abstract

Background
Circulating total calcium or albumin-adjusted calcium is a risk factor for cardiovascular disease. As the biologically active ionized calcium is a physiologically more relevant measure and its association with cardiovascular disease is poorly understood, we tested the hypothesis that high plasma ionized calcium is associated with higher risk of myocardial infarction and ischemic stroke in individuals in the general population.

Methods
We included 106 774 individuals from the Copenhagen General Population Study, and defined hypocalcemia and hypercalcemia by the lowest and highest 2.5 percentiles, respectively, using the central 95% reference interval. Information on myocardial infarction and ischemic stroke was from registries and risks calculated using Cox regression and Fine and Gray competing-risks regression.

Results
During a median follow-up of 9.2 years, 4932 individuals received a diagnosis of either myocardial infarction or ischemic stroke. Hypercalcemia was associated with subdistribution hazard ratios of 1.67 (95%CI: 1.05–2.67) for myocardial infarction, 1.28 (0.81–2.02) for ischemic stroke, and of 1.54 (1.10–2.15) for the combined endpoint compared to individuals with plasma ionized calcium within the reference interval; hypocalcemia was not associated with cardiovascular disease. In models using plasma ionized calcium as a continuous variable, the associations were nonlinear; above the median, each 0.1 mmol/L higher plasma ionized calcium was associated with a hazard ratio of 1.31(1.02–1.68) for myocardial infarction, 1.21 (0.95–1.54) for ischemic stroke, and of 1.28 (1.08–1.53) for the combined endpoint.

Conclusions
High plasma ionized calcium is associated with higher risk of myocardial infarction and ischemic stroke compared to plasma ionized calcium within the reference interval.
Long-term outcomes after myocardial infarction in middle-aged and older patients with congenital heart disease—a nationwide study
Authors: Fedchenko Maria , Mandalenakis Zacharias , Giang Kok Wai , Rosengren Annika , Eriksson Peter , Dellborg Mikael 
Published: October 2020

Abstract

Aims
We aimed to describe the risk of myocardial infarction (MI) in middle-aged and older patients with congenital heart disease (ACHD) and to evaluate the long-term outcomes after index MI in patients with ACHD compared with controls.

Methods and results
A search of the Swedish National Patient Register identified 17 189 patients with ACHD (52.2% male) and 180 131 age- and sex-matched controls randomly selected from the general population who were born from 1930 to 1970 and were alive at 40 years of age; all followed up until December 2017 (mean follow-up 23.2 ± 11.0 years). Patients with ACHD had a 1.6-fold higher risk of MI compared with controls [hazard ratio (HR) 1.6, 95% confidence interval (CI) 1.5–1.7, P &lt; 0.001] and the cumulative incidence of MI by 65 years of age was 7.4% in patients with ACHD vs. 4.4% in controls. Patients with ACHD had a 1.4-fold increased risk of experiencing a composite event after the index MI compared with controls (HR 1.4, 95% CI 1.3–1.6, P &lt; 0.001), driven largely by the occurrence of new-onset heart failure in 42.2% (n = 537) of patients with ACHD vs. 29.5% (n = 2526) of controls.

Conclusion
Patients with ACHD had an increased risk of developing MI and of recurrent MI, new-onset heart failure, or death after the index MI, compared with controls, mainly because of a higher incidence of newly diagnosed heart failure in patients with ACHD. Recognizing and managing the modifiable cardiovascular risk factors should be of importance to reduce morbidity and mortality in patients with ACHD.
Multimodal signal dataset for 11 intuitive movement tasks from single upper extremity during multiple recording sessions
Authors: Jeong Ji-Hoon , Cho Jeong-Hyun , Shim Kyung-Hwan , Kwon Byoung-Hee , Lee Byeong-Hoo , Lee Do-Yeun , Lee Dae-Hyeok , Lee Seong-Whan 
Published: October 2020

Abstract

Background
Non-invasive brain–computer interfaces (BCIs) have been developed for realizing natural bi-directional interaction between users and external robotic systems. However, the communication between users and BCI systems through artificial matching is a critical issue. Recently, BCIs have been developed to adopt intuitive decoding, which is the key to solving several problems such as a small number of classes and manually matching BCI commands with device control. Unfortunately, the advances in this area have been slow owing to the lack of large and uniform datasets. This study provides a large intuitive dataset for 11 different upper extremity movement tasks obtained during multiple recording sessions. The dataset includes 60-channel electroencephalography, 7-channel electromyography, and 4-channel electro-oculography of 25 healthy participants collected over 3-day sessions for a total of 82,500 trials across all the participants.

Findings
We validated our dataset via neurophysiological analysis. We observed clear sensorimotor de-/activation and spatial distribution related to real-movement and motor imagery, respectively. Furthermore, we demonstrated the consistency of the dataset by evaluating the classification performance of each session using a baseline machine learning method.

Conclusions
The dataset includes the data of multiple recording sessions, various classes within the single upper extremity, and multimodal signals. This work can be used to (i) compare the brain activities associated with real movement and imagination, (ii) improve the decoding performance, and (iii) analyze the differences among recording sessions. Hence, this study, as a Data Note, has focused on collecting data required for further advances in the BCI technology.
On-axis triplications in elastic orthorhombic media
Authors: Xu Shibo , Stovas Alexey , Mikada Hitoshi , Takekawa Junichi 
Published: October 2020

SUMMARY
Triplicated traveltime curve has three arrivals at a given distance with the bowtie shape in the traveltime-offset curve. The existence of the triplication can cause a lot of problems such as several arrivals for the same wave type, anomalous amplitudes near caustics, anomalous behaviour of rays near caustics, which leads to the structure imaging deviation and redundant signal in the inversion of the model parameters. Hence, triplication prediction becomes necessary when the medium is known. The research of the triplication in transversely isotropic medium with a vertical symmetry axis (VTI) has been well investigated and it has become clear that, apart from the point singularity case, the triplicated traveltime only occurs for S wave. On contrary to the VTI case, the triplication behaviour in the orthorhombic (ORT) medium has not been well focused due to the model complexity. In this paper, we derive the second-order coefficients of the slowness surface for two S waves in the vicinity of three symmetry axes and define the elliptic form function to examine the existence of the on-axis triplication in ORT model. The existence of the on-axis triplication is found by the sign of the defined curvature coefficients. Three ORT models are defined in the numerical examples to analyse the behaviour of the on-axis triplication. The plots of the group velocity surface in the vicinity of three symmetry axes are shown for different ORT models where different shapes: convex or the saddle-shaped (concave along one direction and convex along with another) indicates the existence of the on-axis triplication. We also show the traveltime plots (associated with the group velocity surface) to illustrate the effect of the on-axis triplication.
Ubiquitous expression of Akt1 p.(E17K) results in vascular defects and embryonic lethality in mice
Authors: Lindhurst Marjorie J , Li Wenling , Laughner Nathaniel , Shwetar Jasmine J , Kondolf Hannah C , Ma Xuefei , Mukouyama Yoh-suke , Biesecker Leslie G 
Published: October 2020

Abstract
Proteus syndrome is a progressive overgrowth disorder with vascular malformations caused by mosaic expression of the AKT1 c.49G &gt; A, p.(E17K) activating variant which was predicted to cause lethality if expressed ubiquitously. To test that hypothesis, we used the ACTB-Cre gene to activate a conditional Akt1 p.(E17K) allele in the mouse. No offspring that was heterozygous for both Cre and the conditional allele (βA-Akt1WT/flx) was viable. Fewer than expected numbers of βA-Akt1WT/flx embryos were seen beginning at E11.5, but a few survived until E17.5. The phenotype ranged from mild to severe, but generally βA-Akt1WT/flx embryos had fewer visible blood vessels and more hemorrhages than their wild-type littermates, which was suggestive of a vascular abnormality. Examination of E13.5 limb skin showed a primitive capillary network with increased branching complexity and abnormal patterning compared with wild-type skin. By E15.5, wild-type skin had undergone angiogenesis and formed a hierarchical network of remodeled vessels, whereas in βA-Akt1WT/flx embryos, the capillary network failed to remodel. Mural cell coverage of the blood vessels was also reduced in βA-Akt1WT/flx skin compared with that of wild type. Restricting expression of Akt1E17K to endothelial, cardiac or smooth muscle cells resulted in viable offspring and remodeled vasculature and did not recapitulate the βA-Akt1WT/flx phenotype. We conclude that ubiquitous expression of Akt1E17K suppresses remodeling and inhibits the formation of a normal skin vasculature. We postulate that this failure prevents proper circulation necessary to support the growing embryo and that it is the result of interactions of multiple cell types with increased AKT signaling.
Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity
Authors: Fang Xin , Vázquez-Baeza Yoshiki , Elijah Emmanuel , Vargas Fernando , Ackermann Gail , Humphrey Gregory , Lau Rebecca , Weldon Kelly C , Sanders Jon G , Panitchpakdi Morgan , Carpenter Carolina , Jarmusch Alan K , Neill Jennifer , Miralles Ara , Dulai Parambir , Singh Siddharth , Tsai Matthew , Swafford Austin D , Smarr Larry , Boyle David L , Palsson Bernhard O , Chang John T , Dorrestein Pieter C , Sandborn William J , Knight Rob , Boland Brigid S 
Published: October 2020

Abstract

Background
Many studies have investigated the role of the microbiome in inflammatory bowel disease (IBD), but few have focused on surgery specifically or its consequences on the metabolome that may differ by surgery type and require longitudinal sampling. Our objective was to characterize and contrast microbiome and metabolome changes after different surgeries for IBD, including ileocolonic resection and colectomy.

Methods
The UC San Diego IBD Biobank was used to prospectively collect 332 stool samples from 129 subjects (50 ulcerative colitis; 79 Crohn’s disease). Of these, 21 with Crohn’s disease had ileocolonic resections, and 17 had colectomies. We used shotgun metagenomics and untargeted liquid chromatography followed by tandem mass spectrometry metabolomics to characterize the microbiomes and metabolomes of these patients up to 24 months after the initial sampling.

Results
The species diversity and metabolite diversity both differed significantly among groups (species diversity: Mann-Whitney U test P value = 7.8e-17; metabolomics, P-value = 0.0043). Escherichia coli in particular expanded dramatically in relative abundance in subjects undergoing surgery. The species profile was better able to classify subjects according to surgery status than the metabolite profile (average precision 0.80 vs 0.68).

Conclusions
Intestinal surgeries seem to reduce the diversity of the gut microbiome and metabolome in IBD patients, and these changes may persist. Surgery also further destabilizes the microbiome (but not the metabolome) over time, even relative to the previously established instability in the microbiome of IBD patients. These long-term effects and their consequences for health outcomes need to be studied in prospective longitudinal trials linked to microbiome-involved phenotypes.
Categories and health impacts of intimate partner violence in the World Health Organization multi-country study on women’s health and domestic violence
Authors: Potter Lucy C , Morris Richard , Hegarty Kelsey , García-Moreno Claudia , Feder Gene 
Published: October 2020

Abstract

Background
Intimate partner violence (IPV) damages health and is costly to families and society. Individuals experience different forms and combinations of IPV; better understanding of the respective health effects of these can help develop differentiated responses. This study explores the associations of different categories of IPV on women’s mental and physical health.

Methods
Using data from the World Health Organization (WHO) Multi-Country Study on Women’s Health and Domestic Violence, multilevel mixed effects logistic regression modelling was used to analyse associations between categories of abuse (physical IPV alone, psychological IPV alone, sexual IPV alone, combined physical and psychological IPV, and combined sexual with psychological and/or physical IPV) with measures of physical and mental health, including self-reported symptoms, suicidal thoughts and attempts, and nights in hospital.

Results
Countries varied in prevalence of different categories of IPV. All categories of IPV were associated with poorer health outcomes; the two combined abuse categories were the most damaging. The most common category was combined abuse involving sexual IPV, which was associated with the poorest health [attempted suicide: odds ratio (OR): 10.78, 95% confidence interval (CI) 8.37-13.89, thoughts of suicide: 8.47, 7.03-10.02, memory loss: 2.93, 2.41-3.56]. Combined psychological and physical IPV was associated with the next poorest outcomes (attempted suicide: 5.67, 4.23-7.60, thoughts of suicide: 4.41, 3.63-5.37, memory loss: 2.33, 1.88-2.87-).

Conclusions
Understanding the prevalence and health impact of different forms and categories of IPV is crucial to risk assessment, tailoring responses to individuals and planning services. Previous analyses that focused on singular forms of IPV likely underestimated the more harmful impacts of combined forms of abuse.
New results on robust sliding mode control for linear time-delay systems
Authors: Palraj Jothiappan , Mathiyalagan Kalidass , Shi Peng 
Published: October 2020

AbstractThis work focuses on the sliding mode control (SMC) for a family of linear systems with uncertainties and time-varying delays. First, an integral switching surface is constructed to verify the robust asymptotic stability of the considered system and the results are extended to analyse the mixed $\mathscr{H}_{\infty }\big /$Passivity performance index. Thereafter, a suitable SMC law is developed to force the system state onto the predefined switching surface in short time. By using Lyapunov stability theory, some novel results are obtained, and the required stability conditions are established in terms of linear matrix inequalities which can be solved by standard Matlab toolbox. Finally, the results are validated over a Chua’s circuit model, which describes the practical application of the developed results.
The Effect of Sample Handling on Free Valproic Acid Levels
Authors: Wang Dan , Champion-Lyons Elizabeth , Neyens Ron , Bohm Nicole , Caddell Brittany , Babic Nikolina 
Published: October 2020

Abstract

Background
Valproic acid (VPA) is a broad-spectrum anticonvulsant drug. Under normal conditions, this drug is highly protein bound. However, in patients with hypoalbuminemia, the free fraction can increase substantially while the total VPA levels remain in therapeutic range. The neurologic activity and toxicity of the drug are directly related to free drug levels.

Methods
Our in-house free VPA assay was validated using 20 patient samples obtained from a reference laboratory (RL1). It was further evaluated by parallel testing with RL1 using samples collected from our patients. Subsequently, sample handling effects were investigated by comparing free VPA levels measured in our laboratory to 3 selected RLs with different sample transportation conditions.

Results
No significant bias was observed between the in-house assay (y) and RL1 (x) assay in free VPA measurement (y = 1.12x + 0.072, r = 0.994). However, patient samples collected in our institution and sent to RL1 revealed significant negative bias (y = 0.776x − 3.861, r = 0.954). A large discrepancy in free VPA levels was further observed from identical aliquots of the same samples transported to 3 RLs in different conditions.

Conclusions
Our study demonstrated that sample handling has significant impact on free VPA levels. The observed magnitude of variation exceeds a clinically acceptable limit and could alter clinical decisions.
Effects of feeding level on efficiency of high- and low-residual feed intake beef steers
Authors: Andreini Emily M , Augenstein Sheyenne M , Fales Carrie S , Sainz Roberto D , Oltjen James W 
Published: October 2020

Abstract
Comparing heat production after ad libitum (ADLIB) and restricted (RESTRICT) feeding periods may offer insight into how residual feed intake (RFI) groups change their energy requirements based on previous feeding levels. In this study, the authors sought to explain the efficiency changes of high- and low-RFI steers after feed restriction. To determine RFI classification, 56 Angus-cross steers with initial body weight (BW) of 350 ± 28.7 kg were individually housed, offered ad libitum access to a total mixed ration, and daily intakes were recorded for 56 d. RFI was defined as the residual of the regression of dry matter intake on mid-test BW0.75 and average daily gain. High- and low-RFI groups were defined as &gt;0.5 SD above or below the mean of zero, respectively. Fourteen steers from each high and low groups (n = 28) were selected for the subsequent 56-d RESTRICT period. During the RESTRICT period, intake was restricted to 75% of previous ad libitum intake on a BW0.75 basis, and all other conditions remained constant. After the RESTRICT period, both RFI groups had decreased maintenance energy requirements. However, the low-RFI group decreased maintenance energy requirements by 32% on a BW0.75 basis, more (P &lt; 0.05) than the high-RFI group decreased maintenance requirements (18%). Thus, the low-RFI steers remained more efficient after a period of feed restriction. We conclude that feed restriction decreases maintenance energy requirement in both high- and low-RFI groups that are restricted to the same degree.
Evaluating the utility of a CO2 surgical laser for piglet castration to reduce pain and improve wound healing: a pilot study
Authors: Viscardi Abbie V , Cull Charley A , Kleinhenz Michael D , Montgomery Shawnee , Curtis Andrew , Lechtenberg Kelly , Coetzee Johann F 
Published: October 2020

AbstractCO2 surgical lasers are widely used for procedures in veterinary and human medicine. There is evidence to suggest surgery using a CO2 laser reduces pain and swelling and improves healing time compared with surgery with a scalpel. Millions of piglets in North America are surgically castrated each year using a scalpel. Therefore, piglet welfare may be improved by making refinements to the surgical procedure. The objectives of this preliminary study were to determine the ability of a CO2 surgical laser to (1) reduce pain and (2) improve wound healing of piglets undergoing surgical castration. Two-day-old male Yorkshire × Landrace piglets were used and randomly assigned to 1 of 3 treatments (n = 10 piglets/treatment group): surgical castration with the CO2 laser, surgical castration with a scalpel, or sham (uncastrated control). Piglets were video recorded in their pens for 1 hr preprocedure and from 0 to 2, 6 to 8, and at 24 hr postprocedure for behavior scoring. Surgical site images were collected at baseline, 0, 8, 24, 48, 72, 96, 120, 144, and 168 hr postcastration for wound healing assessment. Infrared thermography images of the surgical site were also taken at baseline, 0, 0.5, 8, and 24 hr postprocedure to assess inflammation. Finally, blood was collected from each piglet at baseline and 0.5 hr postcastration to assess cortisol levels, prostaglandin E metabolite and pig-major acute phase protein concentration. Laser-castrated piglets displayed more pain behaviors across the observation period than scalpel-castrated piglets (P = 0.05). Laser-castrated piglets also displayed significantly more agonistic behavior than both scalpel-castrated piglets (P = 0.005) and sham piglets (P = 0.036); yet, laser-castrated piglets had significantly lower temperatures at the site of incision compared with scalpel-castrated piglets (P = 0.0211). There was no significant difference in wound healing or any of the blood parameters assessed between laser-castrated and scalpel-castrated piglets. There was evidence of thermal tissue damage on the scrotum of piglets that were castrated using the CO2 laser. This may have resulted in the unremarkable healing time and the increased pain behavior observed in this study. The surgical laser technique should be refined before conclusions can be made regarding the utility of a CO2 laser for piglet castration.