bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forest cover and fruit crop size differentially influence frugivory of select rainforest tree species in Western Ghats, India
Authors: Gopal Abhishek , Mudappa Divya , Raman T. R. Shankar , Naniwadekar Rohit 
Published: June 2020

AbstractForest fragmentation and habitat loss are major disruptors of plant–frugivore interactions, affecting seed dispersal and altering recruitment patterns of the dependent tree species. In a heterogeneous production landscape (primarily tea and coffee plantations) in the southern Western Ghats, India, we examined effects of surrounding forest cover and fruit crop size on frugivory of four rainforest bird‐dispersed tree species (N = 131 trees, ≥30 trees per species, observed for 623 hr). Frugivore composition differed among the four tree species with the large‐seeded Canarium strictum and Myristica dactyloides being exclusively dependent on large‐bodied avian frugivores, whereas medium‐seeded Persea macrantha and Heynea trijuga were predominantly visited by small‐bodied and large‐bodied avian frugivores, respectively. Using the seed‐dispersal‐effectiveness framework, we identified effective frugivores and examined their responses to forest cover and fruit crop size. Results were idiosyncratic and were governed by plant and frugivore traits. Visitations to medium‐seeded Persea had a positive relationship with forest cover but the relationship was negative for the large‐seeded Myristica. In addition, two of the three effective frugivores for Persea responded to the interactive effect of forest cover and fruit crop size. Frugivore visitations to Heynea were not related to forest cover or fruit crop, and there were too few visitations to Canarium to discern any trends. These results highlight the context‐specific responses of plant–frugivore interactions to forest cover and fruit crop size influenced by plant and frugivore traits.
A scoping review of cost‐effectiveness analyses of school‐based interventions for caries
Authors: Amilani Uttara , Carter Hannah E. , Senanayake Sameera , Hettiarachchi Ruvini M. , McPhail Steven M. , Kularatna Sanjeewa 
Published: June 2020

AbstractObjectivesThe aims of this study were to: identify the evidence on cost‐effectiveness of school‐based interventions for caries prevention globally up to 2019; summarize key characteristics of interventions applied within this setting; summarize the reporting quality of previous studies; and to identify and analyse knowledge gaps.MethodsA scoping review of published literature on the cost‐effectiveness of school‐based interventions to prevent child tooth decay was conducted. A search in Medline, Cinahl and Embase was performed with no date restriction. Reporting quality of the included studies was assessed against Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.ResultsOf the 738 records identified in the initial search, 15 studies met the pre‐specified inclusion criteria. The majority were published after 2011 (n = 9,) and applied to high‐income countries (n = 12). Nearly 80% of the studies assessed the cost‐effectiveness of the interventions based on topical fluoride therapies and fissure sealants at school premises. Although, the outcome measures differed across the studies, almost all the caries preventive interventions were cost‐saving or cost‐effective when compared with usual care. Compliance with the CHEERS checklist differed.ConclusionsThere is evidence to suggest that school‐based caries preventive interventions are cost‐effective, and in some cases cost‐saving. Further evidence is required from low‐ to middle‐income countries to confirm the generalizability of these findings. Future studies should consider adopting Quality Adjusted Life Years as a generic outcome measure that would enable the cost‐effectiveness findings to be compared across different types of interventions and diseases. Improved standardization and quality of reporting are also required.
Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model
Authors: Park Kyung Hee , Oh Eun Yi , Han Heejae , Kim Jung Dong , Kim Sung Jin , Jeong Kyoung Yong , Kim Ji Hye , Park Chang Ook , Kim Sung‐Ryeol , Lee Jae‐Hyun , Jeong Do Hyeon , Yong Tai‐Soon , Lee Kwang Hoon , Park Jung‐Won 
Published: June 2020

AbstractBackgroundHouse dust mite (HDM) is a well‐known cause of asthma. Allergen‐specific immunotherapy (AIT) can only modify the natural course of the disease. Conventional routes of HDM AIT are subcutaneous or sublingual. Subcutaneous immunotherapy (SCIT) has a disadvantage of systemic hypersensitive reaction, and the sublingual immunotherapy has a disadvantage of local allergic reaction and low drug adherence.ObjectiveTo overcome the weak points of conventional AIT, we developed a HDM loaded biodegradable microneedle patch (MNP) for transdermal immunotherapy (TDIT). We aim to demonstrate the efficacy of TDIT in murine asthma model triggered by HDM compared with conventional SCIT.MethodsTo make HDM asthma mouse model, 5‐week‐old BALB/c female mice were sensitized and challenged by intranasal administration of HDM. The mice were divided into 5 groups: sham, asthma, low (10 µg) and high dose (100 µg) SCIT, and TDIT (10 µg). To make HDM loaded MNP, droplet‐born air blowing method was used. Airway hyperresponsiveness and allergic inflammation markers were analysed by bronchoalveolar lavage fluid, immunohistochemistry, serum immunoglobulin (Ig) analysis, and lung cytokine assays.ResultsAirway hyperresponsiveness was ameliorated by TDIT. Eosinophilic inflammation in bronchoalveolar lavage was improved without adverse reactions. Reduction of Th2 (IL‐4, IL‐5, and IL‐13) cytokines, and HDM‐specific IgE, induction of Treg (IL‐10, TGF‐β), Th1 (IFN‐γ) cytokines were observed. Eosinophilic infiltration, goblet cell hyperplasia, and subepithelial fibrosis were also alleviated by TDIT. These changes were more significant in the TDIT group than in subcutaneous AIT group.ConclusionIn conclusion, HDM loaded biodegradable TDIT is a novel treatment option to treat asthma which showed more effectiveness and may have better safety profiles than conventional SCIT.
Total‐evidence analysis of an undescribed fauna: resolving the evolution and classification of Australia’s golden trapdoor spiders (Idiopidae: Arbanitinae: Euoplini)
Authors: Wilson Jeremy D. , Raven Robert J. , Schmidt Daniel J. , Hughes Jane M. , Rix Michael G. 
Published: June 2020

AbstractIn the trapdoor spider genus Euoplos Rainbow & Pulleine (tribe Euoplini), it was discovered recently that two divergent lineages occur in sympatry in eastern Australia. This challenged the monogeneric classification of the tribe and, in combination with inadequate taxonomic descriptions of some species, precluded comprehensive taxonomic revision. To resolve these issues, we conducted a total‐evidence cladistic analysis on a largely undescribed continental fauna—the first such analysis on a group of Australian Mygalomorphae. We combined multilocus molecular data and/or morphological and behavioural data from all known species from eastern Australia (described and undescribed), plus a subset of Western Australian species, to produce a phylogeny for the tribe. We mapped morphological/behavioural characters onto this to identify clade‐specific diagnostic characters, and applied these data to a generic reclassification of the tribe. We recovered two sympatric lineages in the Euoplini (the “wafer‐door” and “plug‐door/palisade” lineages), and revealed the phylogenetic position of all known eastern Australian species within these. Character mapping revealed morphological and behavioural (burrow architecture) features that allow diagnosis of the lineages and clades within them. We erect a new genus, Cryptoforis gen.n., to represent the wafer‐door lineage, describe the type species, Cryptoforis hughesae sp.n., and transfer two species from Euoplos to Cryptoforis: C. tasmanica (Hickman, 1928) and C. victoriensis (Main, 1995). This study resolves phylogenetic structure within the Euoplini, and characterizes clades within the tribe to facilitate future taxonomic revisions. It also demonstrates that, whereas male morphology is more informative, female morphological characters relating to genitalia and the scopulation/spination of the anterior legs display phylogenetic signal in the Euoplini, highlighting the subtle nature of informative female characters in mygalomorph spiders.
Metformin protects against mouse oocyte apoptosis defects induced by arecoline
Authors: Li Wei‐Dong , Zang Chuan‐jie , Yin Shen , Shen Wei , Sun Qing‐Yuan , Zhao Minghui 
Published: June 2020

AbstractObjectivesArecoline is the main bioactive substance extracted from Areca catechu L, which has cell, neural and genetic toxicity. The function of arecoline in reproductive system has not been well explored.Materials and MethodsTo investigate the toxic effects of arecoline on oocyte development, immunofluorescence staining, qPCR, Western blotting, sperm binding assays and in vitro fertilization were performed to evaluate oocyte meiosis competence and embryo development.ResultsOur data revealed that arecoline exposure disrupts actin filament dynamics, spindle assembly and kinetochore‐microtubule attachment stability in mouse oocytes, leading to aneuploidy and oocyte meiosis arrest. In addition, arecoline treatment disturbs the distribution of mitochondria, reduces ATP production and increases the level of oxidative stress, which ultimately induces oocyte apoptosis. Supplementation with metformin, a medicine for type 2 diabetes in the clinic, partially alleviates these damages.ConclusionsMetformin has a protective effect on arecoline‐induced mouse oocytes apoptosis.
Waste Political Settlements in Colombia and Chile: Power, Inequality and Informality in Recycling
Authors: Valenzuela‐Levi Nicolás 
Published: June 2020

ABSTRACTThere are stark differences between the waste recycling literature from the global North and that from the global South. The literature from the global North tends to focus on empirical analyses of existing municipal recycling services and rarely considers institutional factors. When it does, the theoretical approaches adopted are limited, especially regarding the role of informal institutions. In contrast, recycling literature from the global South does focus on informal institutions, but it does so by concentrating on the struggles of waste pickers rather than on the performance of waste management services provided by local authorities. This divergence in the literature suggests the need for an analytical framework that integrates institutions and recycling performance. This article analyses waste disposal regimes in two Latin American metropolitan areas, Medellín (Colombia) and Santiago (Chile), and explores the link between income inequality and recycling. It focuses on the political settlements that lie at the heart of the waste regimes. As such, waste regimes in these two cities are understood to be a product of the interplay of balances of power, institutions and distribution of benefits. The study also highlights the need to understand informal institutions as relational phenomena that affect both the rich and the poor, and not just as a subsistence strategy by the latter.
Infant and child mortality by socio‐economic status in early nineteenth‐century England †
Authors: Jaadla Hannaliis , Potter Ellen , Keibek Sebastian , Davenport Romola 
Published: June 2020

AbstractHistorical relationships between socio‐economic status and mortality remain poorly understood. This is particularly the case in England, due to a lack of status indicators in available sources especially beforec. 1850. This study uses the paternal occupational descriptors routinely recorded in Anglican baptism registers from 1813–37 to compare infant and early childhood mortality by social status. The sample consists of eight of the Cambridge Group family reconstitution parishes, which make it possible to investigate the contributions of environment as well as household characteristics. The main variable of interest was an individual‐level continuous measure of wealth based on ranking paternal occupations by the propensity for their movable wealth to be inventoried upon death. The findings show that wealth conferred no clear survival advantage in infancy, once differences in average mortality levels between parishes were adjusted for. However, wealth was associated with higher survival rates in early childhood, especially in the second year of life, and this pattern persisted after adjustment for parish‐level effects. The striking exception to this pattern was labourers, who were among the poorest of fathers but whose children enjoyed relatively low mortality. Thus socio‐economic differentials in mortality were present in early nineteenth‐century England; however, they were small, age‐specific, and non‐linear.
Shedding light on a dark matter: Jump diffusion and option‐implied investor preferences
Authors: Ghanbari Hamed , Oancea Michael , Perrakis Stylianos 
Published: June 2020

AbstractWe compare equilibrium jump diffusion option prices with endogenously determined stochastic dominance (SD) option bounds. We use model parameters from earlier studies and find that most equilibrium model prices consistent with SD bounds yield economically meaningless results. Further, the implied distributions of the SD bounds exhibit a tail risk comparable to that of the underlying return data, thus shedding light on the dark matter of the inconsistency of physical and risk‐neutral tail probabilities. Since the SD bound assumptions are weaker, we conclude that these bounds should either replace or be used to verify the equilibrium model results.
Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies
Authors: Heilmann‐Heimbach Stefanie , Hochfeld Lara M. , Henne Sabrina K. , Nöthen Markus M. 
Published: June 2020

AbstractMale‐pattern hair loss, also termed androgenetic alopecia (AGA), is a highly prevalent age‐related condition that is characterized by a distinct pattern of hair loss from the frontotemporal and vertex regions of the scalp. The phenotype is highly heritable and hormone dependent, with androgens being the recognized critical hormonal factor. Numerous molecular genetic studies have focused on genetic variation in and around the gene that encodes the androgen receptor. More recently, however, the availability of high‐throughput molecular genetic methods, novel methods of data analysis and sufficiently large sample sizes have rendered possible the systematic investigation of the contribution of other components of the androgen receptor pathway or hormonal pathways beyond the androgen receptor signalling pathways. Over the past decade, genome‐wide association studies of increasingly large cohorts have enabled the genome‐wide identification of genetic risk factors for AGA, and yielded unprecedented insights into the underlying pathobiology. The present review discusses some of the most intriguing genetic findings on the relevance of (sex)hormonal signalling in AGA.
LNAPL Recovery Endpoints: Lessons Learnt Through Modeling, Experiments, and Field Trials
Authors: Sookhak Lari Kaveh , Rayner John L. , Davis Greg B. , Johnston Colin D. 
Published: June 2020

AbstractIt is important to estimate what light nonaqueous phase liquid (LNAPL) recovery can be practicably achieved from subsurface environments. Over the last decade, research to address this included a broad field program, laboratory measurements and experimentation, and modeling approaches. Here, we consolidate key findings from the research in the context of current literature and understanding, with a focus on a well‐validated, multiphase multicomponent modeling approach to achieve estimates of reasonable endpoints for LNAPL recovery. Simple analytical models can provide approximate saturation distributions and estimates of LNAPL recoverability via transmissivity approximation, but are insufficient to predict LNAPL saturation‐ and composition‐based recovery endpoints for various recovery technologies. This is because they cannot account for multiphase, multicomponent fate and transport and key processes such as hysteresis. Recent advances to improve estimates of the fraction of recoverable LNAPL and its transmissivity are summarized. These advances include further development and application of a well‐validated model to characterize active LNAPL recovery endpoints. We present key factors that affect the determination of LNAPL recovery endpoints, and outline how recovery endpoints are affected by natural source zone depletion (NSZD—currently gaining acceptance as a LNAPL remediation option). Major factors include geo‐physical characteristics of the formation, magnitude of an LNAPL release and partitioning properties of the key LNAPL constituents of concern. Based on the capabilities of the validated model, the paper also provides a basis to optimize LNAPL recovery efforts.
S100B and NSE in Cluster Headache – Evidence for Glial Cell Activation?
Authors: Snoer Agneta H. , Vollesen Anne Luise H. , Beske Rasmus Paulin , Guo Song , Hoffmann Jan , Jørgensen Niklas R. , Martinussen Torben , Ashina Messoud , Jensen Rigmor H. 
Published: June 2020

ObjectiveNeuronal‐specific enolase (NSE) and protein S100B have gained considerable interest as the markers of CNS injury, glial cell activation, and/or blood‐brain barrier (BBB) disruption. No studies have investigated NSE and S100B in cluster headache (CH), but these biomarkers could contribute to the understanding of CH.MethodsPatients with episodic CH in bout (eCHa), in remission (eCHr), and chronic CH (cCH) were included in this randomized, double‐blind, placebo‐controlled, 2‐way cross‐over provocation study carried out at the Danish Headache Center. The primary endpoints included (1) differences of NSE and S100B in between groups (eCHa, eCHr, and cCH) at baseline; (2) differences over time in plasma concentrations of NSE and S100B between patient developing an attack and those who did not; (3) differences in plasma concentrations over time of NSE and S100B between active day and placebo day. Baseline findings were compared to the historical data on migraine patients and healthy controls and presented with means ± SD.ResultsNine eCHa, 9 eCHr, and 13 cCH patients completed the study and blood samples from 11 CGRP‐induced CH attacks were obtained. There were no differences in NSE levels between CH groups at baseline, but CH patients in active disease phase had higher levels compared with 32 migraine patients (9.1 ± 2.2 µg/L vs 6.0 ± 2.2 µg/L, P < .0001) and 6 healthy controls (9.1 ± 2.2 µg/L vs 7.3 ± 2.0 µg/L, P = .007). CGRP‐infusion caused no NSE changes and, but a slight, non‐significant, increase in NSE was seen in patients who reported a CGRP‐induced CH attack (2.39 µg/L, 95% Cl [−0.26, 3.85], P = .061). At baseline S100B levels in eCHa patients were higher compared to cCH patients (0.06 ± 0.02 µg/L vs 0.04 ± 0.02 µg/L, P = .018). Infusion of CGRP and CGRP‐induced attacks did not change S100B levels. Apart from induced CH‐attacks no other adverse events were noted.ConclusionsAt baseline eCHa patients had higher S100B plasma levels than cCH patients and there was a slight, however not significant, NSE increase in response to CGRP‐induced CH attack. Our findings suggest a possible role of an ictal activation of glial cells in CH pathophysiology, but further studies are warranted.
Post‐exposure prophylaxis completion and condom use in the context of potential sexual exposure to HIV*
Authors: Gantner P , Allavena C , Duvivier C , Cabie A , Reynes J , Makinson A , Ravaux I , Bregigeon S , Cotte L , Rey D ,   the Dat'AIDS Study Group
Published: June 2020

ObjectivesPost‐exposure prophylaxis (PEP) care remains a challenge for individuals with potential sexual exposure to HIV in terms of PEP completion and ongoing risk behaviours.MethodsA retrospective analysis was carried out on data from the French Dat’AIDS prevention cohort (NCT03795376) for individuals evaluated for PEP between 2004 and 2017. A multivariable analysis was performed of predictors of both PEP completion and condom use [odds ratios (ORs)] and their associated probabilities (P, with P > 95% being clinically relevant).ResultsOverall, 29 060 sexual exposures to HIV were evaluated for PEP [36% in men who have sex with men (MSM) and 64% in heterosexuals]. Overall, 12 different PEP regimens were offered in 19 240 cases (46%). Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) was the preferred backbone (n = 14 304; 74%). We observed a shift from boosted protease inhibitor‐based regimens to nonnucleoside reverse transcriptase inhibitor‐ or integrase inhibitor‐based regimens in recent years. Overall, 20% of PEP prescriptions were prematurely discontinued. Older age, MSM, intercourse with a sex worker, rape and intercourse with a known HIV‐infected source patient were factors associated with increased rates of PEP completion (OR > 1; P > 98%). None of the 12 PEP regimens was associated with premature discontinuation. We also found 12 774 cases of unprotected sexual intercourse (48%). Condom use decreased (OR < 1; P > 99%) with the year of exposure, and was lower in MSM and rape victims. Condom use increased (OR > 1, P > 99%) with age, and was higher in those who had intercourse with a sex worker or with a female partner and in those with knowledge of the partner’s HIV status.ConclusionsWe provide new insights into how rates of condom use and PEP completion might be improved in those receiving PEP by targeting certain groups of individuals for interventions. In particular, youth and MSM at risk should be linked in a prevention‐to‐care continuum.
Distinct risks, clinical characteristics and outcomes by age at time of HIV diagnosis
Authors: McMillan JM , Gill MJ , Rubin LH 
Published: June 2020

ObjectivesNew HIV diagnoses in persons aged > 50 years (hereafter ‘older persons’) are becoming more common; the clinical features and outcomes of these older individuals are poorly described.MethodsWe conducted a retrospective cohort study of all new adult HIV diagnoses between October 1989 and December 2019 in southern Alberta, Canada. Differences in risk for HIV acquisition and screening, sociodemographic/clinical characteristics, and causes of death were compared between individuals younger and older than 50 years at the time of diagnosis.ResultsNew HIV diagnoses in persons > 50 years old increased from 7% in 1990 to 18% in 2019. Risk for HIV acquisition and screening reasons differed by age. Heterosexual sex (29%) was the greatest risk factor among older persons, contrasting with male same sex activity in younger persons (51%) (P < 0.001). Illness was the most common indication for testing in older persons (47%), whereas younger persons were more likely to have requested testing (34%) (P < 0.001). Relationship status differed, with 33% of older persons being married to an opposite sex partner versus 12% in younger persons (P < 0.001). Although older persons had a lower mean nadir CD4 count (132 cells/µL) than younger persons (181 cells/µL) (P < 0.001), 80% of deaths between 2010 and 2019 in the older group were attributable to non‐AIDS‐related causes versus 47% in younger patients. Since 2000, AIDS‐related deaths and potential years of life lost have declined for both age groups.ConclusionThe increase in new HIV diagnoses in persons aged > 50 years in southern Alberta suggests that older individuals require customized approaches for optimizing HIV diagnosis and treatment.