bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teachers' perceptions of culturally responsive teaching in technology‐supported learning environments
Authors: Chuang Hsueh‐Hua , Shih Ching‐Lin , Cheng Ming‐Min 
Published: February 2020

AbstractThis study developed and validated an instrument for assessing teachers' perceptions of culturally responsive teaching (CRT) in technology‐supported learning environments (TSLE). Data were collected from a total of 257 elementary and secondary school teachers in Taiwan during March and April 2018 to verify the reliability and construct validity of the instrument. The construct validity of this instrument was examined via confirmatory factor analysis and a multidimensional partial credit model for item responses in which an 18‐item instrument (4 items regarding cultural values, 3 regarding culturally relevant curricula, 4 regarding cultural scaffolding, 3 regarding multicultural collaboration, and 4 regarding integrating with technology and multicultural perspectives) was validated after the elimination of 4 items. The reliability of the instrument was found to be satisfactory according to multidimensional versions of the partial credit model analysis. Regression analysis showed that technology experiences and technology experiences in teaching were positive predictors while school level was a negative predictor of teachers’ perceived CRT in TSLE. Elementary school teachers were more likely to have positive perceptions of CRT in TSLE than were secondary school teachers.
Practitioner NotesWhat is already known about this topic

Well‐developed culturally responsive teaching (CRT) frameworks can facilitate teachers' understanding of how students' cultural backgrounds and experiences can be used to enhance student learning.
Digital tools and technology activities have been demonstrated to be among the best practices for teaching to multicultural classrooms due to the large differences in ethnically diverse student populations.
CRT is a fundamental pedagogical approach that should be included in teacher preparation and applied in learning activities in culturally diverse classrooms.
What this paper adds

We developed and validated an instrument for assessing teachers' perceptions of CRT perceptions in technology‐supported learning environments (TSLE).
Results from this study showed that teachers' technology experiences and technology experiences in teaching were found to positively predict teachers' perceived CRT in TSLE.
School level was found to be a negative predictor of teachers' CRT perceptions in TSLE, indicating that an elementary school teacher was more likely to have a positive perception of CRT in TSLE than a secondary school teacher.
Implications for practice and/or policy

Professional training and pedagogical modelling of technology use, especially in classrooms with culturally diverse students, is highly recommended.
More technology‐related knowledge and more experience using technology in teaching may prompt teachers to modify their teaching within culturally diverse students in TSLE.
An alpha‐defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft‐versus‐host disease
Authors: Rashidi Armin , Herman Adam , Gomes Antonio L. C. , Peled Jonathan U. , Jenq Robert R. , Brereton Daniel G. , Staley Christopher , Blazar Bruce R. , Weisdorf Daniel J. 
Published: February 2020

SummaryWe previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α‐defensin‐5 against acute graft‐versus‐host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri‐engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II–IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28–1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.
MicroRNA‐361‐3p is a potent therapeutic target for oral squamous cell carcinoma
Authors: Ogawa Himiko , Nakashiro Koh‐ichi , Tokuzen Norihiko , Kuribayashi Nobuyuki , Goda Hiroyuki , Uchida Daisuke 
Published: February 2020

AbstractMicroRNAs (miRNAs) can act not only as tumor suppressor genes but also as oncogenes. Oncogenic miRNAs (oncomiRs) could therefore provide opportunities for the treatment of human malignancies. Here, we aimed to identify oncomiRs present in oral squamous cell carcinoma (OSCC) and addressed whether targeting these miRNAs might be useful in treatment for cancer. Functional screening for oncomiRs in a human OSCC cell line (GFP‐SAS) was carried out using the miRCURY LNA microRNA Knockdown Library – Human version 12.0. We identified a locked nucleic acid (LNA)/DNA antisense oligonucleotide against miR‐361‐3p (LNA‐miR‐361‐3p) which showed the largest degree of growth inhibition of GFP‐SAS cells. Transfection with a synthetic mimic of mature miR‐361‐3p resulted in an approximately 20% increase in the growth of GFP‐SAS cells. We identified odd‐skipped related 2 (OSR2) as a miR‐361‐3p target gene. Transfection of GFP‐SAS cells with LNA‐miR‐361‐3p caused a significant increase in the expression levels of OSR2. Cotransfection of a OSR2 3′‐UTR luciferase reporter plasmid and LNA‐miR‐361‐3p into GFP‐SAS cells produced higher levels of luciferase activity than in cells cotransfected with the LNA‐nontarget. We assessed the effect of LNA‐miR‐361‐3p on the in vivo growth of GFP‐SAS cells. We found that LNA‐miR‐361‐3p significantly reduced the size of s.c. xenografted GFP‐SAS tumors, compared to the control group treated with LNA‐NT. Finally, we observed that miR‐361‐3p is overexpressed in OSCC tissues. These results suggest that miR‐361‐3p supports the growth of human OSCC cells both in vitro and in vivo and that targeting miR‐361‐3p could be a useful therapeutic approach for patients with OSCC.
Upregulation of adipocyte enhancer‐binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer
Authors: Yorozu Akira , Yamamoto Eiichiro , Niinuma Takeshi , Tsuyada Akihiro , Maruyama Reo , Kitajima Hiroshi , Numata Yuto , Kai Masahiro , Sudo Gota , Kubo Toshiyuki , Nishidate Toshihiko , Okita Kenji , Takemasa Ichiro , Nakase Hiroshi , Sugai Tamotsu , Takano Kenichi , Suzuki Hiromu 
Published: February 2020

AbstractTumor angiogenesis is an important therapeutic target in colorectal cancer (CRC). We aimed to identify novel genes associated with angiogenesis in CRC. Using RNA sequencing analysis in normal and tumor endothelial cells (TECs) isolated from primary CRC tissues, we detected frequent upregulation of adipocyte enhancer‐binding protein 1 (AEBP1) in TECs. Immunohistochemical analysis revealed that AEBP1 is upregulated in TECs and stromal cells in CRC tissues. Quantitative RT‐PCR analysis showed that there is little or no AEBP1 expression in CRC cell lines, but that AEBP1 is well expressed in vascular endothelial cells. Levels of AEBP1 expression in Human umbilical vein endothelial cells (HUVECs) were upregulated by tumor conditioned medium derived from CRC cells or by direct coculture with CRC cells. Knockdown of AEBP1 suppressed proliferation, migration, and in vitro tube formation by HUVECs. In xenograft experiments, AEBP1 knockdown suppressed tumorigenesis and microvessel formation. Depletion of AEBP1 in HUVECs downregulated a series of genes associated with angiogenesis or endothelial function, including aquaporin 1 (AQP1) and periostin (POSTN), suggesting that AEBP1 might promote angiogenesis through regulation of those genes. These results suggest that upregulation of AEBP1 contributes to tumor angiogenesis in CRC, which makes AEBP1 a potentially useful therapeutic target.
Targeting claudin‐4 enhances chemosensitivity in breast cancer
Authors: Luo Yi , Kishi Shingo , Sasaki Takamitsu , Ohmori Hitoshi , Fujiwara‐Tani Rina , Mori Shiori , Goto Kei , Nishiguchi Yukiko , Mori Takuya , Kawahara Isao , Kondoh Masuo , Kuniyasu Hiroki 
Published: February 2020

AbstractTriple negative breast cancer (TNBC) is characterized by highly aggressive phenotype, limited treatment options and a poor prognosis. In the present study, we examined the therapeutic effect of anti–claudin (CLDN)‐4 extracellular domain antibody, 4D3, on TNBC. When the expression of CLDN4 and CLDN1 in invasive ductal carcinoma (IDC) was examined in 114 IDC (78 cases from 2004 to 2009 in a single center and 36 cases of tissues array), CLDN1 had lower expression than CLDN4 and was correlated with histological grade. In contrast, expression of CLDN4 was correlated with histological grade, receptor subtype, and stage. CLDN4 expression in human IDC cell lines MCF‐7 (luminal subtype) and MDA‐468 (TNBC) was at the same level. In both cells, paclitaxel (PTX)‐induced growth suppression was enhanced by 4D3. Furthermore, 4D3 increased both intracellular PTX concentration (in both cells) and apoptosis. In the mouse model, 4D3 promoted the antitumor effect of PTX on subcutaneous tumors and reduced lung metastasis. The combination of PTX and 4D3 reduced M2 macrophages and mesenchymal stem cells in the tumor. 4D3 also reduced stemness of the tumors and increased the intratumoral pH. Moreover, concurrent treatment with 4D3, PTX and tamoxifen, or with PTX and tamoxifen in MDA‐468 also showed the same level of antitumor activity and survival as MCF‐7. Furthermore, in a bone metastasis model, combination of PTX and bisphosphonate with 4D3 promoted tumor growth in both cells. Thus, CLDN4 targeting of the antibody facilitated existing therapeutic effects.
Cerebral organoids transplantation improves neurological motor function in rat brain injury
Authors: Wang Zhi , Wang Shu‐Na , Xu Tian‐Ying , Hong Chen , Cheng Ming‐He , Zhu Peng‐Xi , Lin Jian‐Sheng , Su Ding‐Feng , Miao Chao‐Yu 
Published: February 2020

AbstractBackground and PurposeCerebral organoids (COs) have been used for studying brain development, neural disorders, and species‐specific drug pharmacology and toxicology, but the potential of COs transplantation therapy for brain injury remains to be answered.MethodsWith preparation of traumatic brain injury (TBI) model of motor dysfunction, COs at 55 and 85 days (55 and 85 d‐CO) were transplanted into damaged motor cortex separately to identify better transplantation donor for brain injury. Further, the feasibility, effectiveness, and underlying mechanism of COs transplantation therapy for brain injury were explored.Results55 d‐CO was demonstrated as better transplantation donor than 85 d‐CO, evidenced by more neurogenesis and higher cell survival rate without aggravating apoptosis and inflammation after transplantation into damaged motor cortex. Cells from transplanted COs had the potential of multilinage differentiation to mimic in‐vivo brain cortical development, support region‐specific reconstruction of damaged motor cortex, form neurotransmitter‐related neurons, and migrate into different brain regions along corpus callosum. Moreover, COs transplantation upregulated hippocampal neural connection proteins and neurotrophic factors. Notably, COs transplantation improved neurological motor function and reduced brain damage.ConclusionsThis study revealed 55 d‐CO as better transplantation donor and demonstrated the feasibility and efficacy of COs transplantation in TBI, hoping to provide first‐hand preclinical evidence of COs transplantation for brain injury.
Ethmoidal drug‐eluting stent therapy is not superior to nasal corticosteroid spray in the prevention of endoscopic sinus surgery: Results from a randomised, clinical trial
Authors: Taulu Rami , Sillanpää Niko , Numminen Jura , Rautiainen Markus 
Published: February 2020

AbstractObjectivesTo evaluate whether an ethmoidal drug‐eluting stent (DES) (the Relieva Stratus™ MicroFlow Spacer) could better prevent endoscopic sinus surgery (ESS) than standard non‐invasive therapy using corticosteroid nasal spray in patients suffering from chronic rhinosinusitis (CRS).DesignProspective, randomised clinical trial.SettingTertiary referral centre.ParticipantsSixty‐three adult patients with ethmoidal involvement in cone beam computerised tomography (CBCT) whose first‐line medical treatment with topical corticosteroids had failed and who were candidates for ESS were randomised either to a DES group, which received triamcinolone acetonide stents (n = 34), or to a topical intranasal corticosteroid group (n = 29) that used optimally dosed triamcinolone acetonide nasal spray.Outcome measuresPatients were followed up prospectively for 6 months and at 36 months. Freedom from ESS was the primary endpoint. Further, we identified those factors predicting ESS.ResultsAt 6 months, ESS could be prevented in almost half of the patients in both groups (DES 13/28, 46.4%, nasal spray 14/29, 48.3%). At 36 months, 20/28 (71.4%) patients in the DES group and 18/29 (62.1%) in the nasal spray group had been operated. The differences were not statistically significant at either timepoint. Patients who smoked (14/19, 73.7% vs 16/38, 42.1%) were more likely to be operated at 6 months.ConclusionEndoscopic sinus surgery can be prevented using both therapies in the medium term in almost half of cases with neither therapy being statistically superior. This effect was somewhat diminished in the long term with a trend towards more patients being operated in the DES group. Considering the additional costs, the need for general anaesthesia and the potential side effects associated with DES, its potential clinical role appears to be limited. Smoking was significantly associated with ESS.
Oral provocation of patients allergic to sesquiterpene lactones with German chamomile tea to demonstrate possible systemic allergic dermatitis
Authors: Lundh Kerstin , Gruvberger Birgitta , Persson Lena , Hindsén Monica , Zimerson Erik , Svensson Åke , Bruze Magnus 
Published: February 2020

AbstractBackgroundMost patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare‐up of hand eczema after ingestion of food and beverages originating from Asteraceae plants.AimTo investigate whether German chamomile tea can elicit systemic allergic dermatitis.Patients and MethodsIndividuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze‐dried German chamomile tea or placebo capsules containing lactose, in a double‐blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare‐up of healed patch test reactions to chamomile.ResultsNone of the subjects had a flare‐up of healed patch test reactions. According to the NRS, SLM‐positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules.ConclusionNo evidence suggestive of systemic allergic dermatitis was found.
Energy‐efficient routing technique for reliable data transmission under the background of big data for disaster region
Authors: Peng Xiaobo , Chang Yanfen 
Published: February 2020

AbstractBig data analysis and cloud computing are gaining much interest in various applications including disaster management. One of the major difficulties in the process of exchanging environmental data in the disaster affected areas has been considered as one of the emerging areas of research. This research focuses on maintaining the environmental data information management of the disaster affected areas, where the intermediate node has been used to transmit the information during transmission and an optimized routing has been used to create efficient data transmission, such as temperature, pressure, humidity, and the level of pollution within the network. The intermediate node may also be hacked during data processing. In this article, the efficient big data‐based clustering technique has been proposed. In this research, the information is grouped into a cluster in every comparable node and the energy consumption has been efficiently managed with the hybrid metaheuristic optimization‐based effective routing technique. The system excellence has been evaluated using the energy utilization factor, packet delivery ratio, and attack‐free routing effectiveness metrics to handle environmental information on disaster affected areas.
Australian birds could benefit from predator exclusion fencing
Authors: Ringma Jeremy , Barnes Megan D. , Bode Michael 
Published: February 2020

AbstractThe use of predator exclusion fencing is widely recognized as one of the most effective mechanisms for protecting threatened fauna from introduced or overabundant predators. It is now used throughout the world to protect avian fauna. In Australia, where predator exclusion fencing is used extensively to protect threatened mammals, such fences for threatened avifauna are surprisingly sparse. In this perspective we demonstrate that (a) the use of predator exclusion fences for avifauna is popular in other countries with similar conservation problems, (b) a large number of Australian avian species could benefit from dedicated predator exclusion fences, and (c) despite legitimate concerns, if well designed, predator exclusion fences can pose little risk to threatened birds or are outweighed by the potential benefits. We believe wider use of predator exclusion fencing to protect Australian threatened birds could be highly beneficial and should be more regularly considered as a management action by conservation practitioners.
Concurrent mycosis fungoides and intravascular large B‐cell lymphoma in a single patient
Authors: Goyal Amrita , Totoraitis Kristin , Toama Wael , He Fiona , Bohjanen Kimberly , Williams Sarah , Miller Daniel D. 
Published: February 2020

AbstractMycosis fungoides (MF) is an indolent, uncommon, non‐Hodgkin T‐cell lymphoma of the skin. It classically presents with patches, plaques, and tumors and may rarely show spread to internal organs or bone marrow. Up to 7.5% of MF patients may be diagnosed with a second malignancy. Intravascular large B‐cell lymphoma (IVLBCL) is an exceedingly rare non‐Hodgkin B‐cell lymphoma characterized by predominant growth of large neoplastic cells in the lumina of blood vessels. This case presents with an unusual confluence of two rare diagnoses, MF and IVLBCL, made more remarkable by the presence of both diagnoses on a single skin biopsy sample.
Urbanization and mortality in Britain, c. 1800–50
Authors: Davenport Romola J. 
Published: February 2020

AbstractIn the long‐running debate over standards of living during the industrial revolution, pessimists have identified deteriorating health conditions in towns as undermining the positive effects of rising real incomes on the ‘biological standard of living’. This article reviews long‐run historical relationships between urbanization and epidemiological trends in England, and then addresses the specific question: did mortality rise especially in rapidly growing industrial and manufacturing towns in the period c. 1830–50? Using comparative data for British, European, and American cities and selected rural populations, this study finds good evidence for widespread increases in mortality in the second quarter of the nineteenth century. However, this phenomenon was not confined to ‘new’ or industrial towns. Instead, mortality rose in the 1830s especially among young children (aged one to four years) in a wide range of populations and environments. This pattern of heightened mortality extended between c. 1830 and c. 1870, and coincided with a well‐established rise and decline in scarlet fever virulence and mortality. The evidence presented here therefore supports claims that mortality worsened for young children in the middle decades of the nineteenth century, but also indicates that this phenomenon was more geographically ubiquitous, less severe, and less chronologically concentrated than previously argued.
Biogeographic historical legacies in the net primary productivity of Northern Hemisphere forests
Authors: Conradi Timo , Van Meerbeek Koenraad , Ordonez Alejandro , Svenning Jens‐Christian 
Published: February 2020

AbstractIt has been suggested that biogeographic historical legacies in plant diversity may influence ecosystem functioning. This is expected because of known diversity effects on ecosystem functions, and impacts of historical events such as past climatic changes on plant diversity. However, empirical evidence for a link between biogeographic history and present‐day ecosystem functioning is still limited. Here, we explored the relationships between Late‐Quaternary climate instability, species‐pool size, local species and functional diversity, and the net primary productivity (NPP) of Northern Hemisphere forests using structural equation modelling. Our study confirms that past climate instability has negative effects on plant functional diversity and through that on NPP, after controlling for present‐day climate, soil conditions, stand biomass and age. We conclude that global models of terrestrial plant productivity need to consider the biogeographical context to improve predictions of plant productivity and feedbacks with the climate system.
Short and Mid‐Term Predictors of Response to OnabotulinumtoxinA: Real‐Life Experience Observational Study
Authors: Alpuente Alicia , Gallardo Víctor José , Torres‐Ferrús Marta , Álvarez‐Sabin José , Pozo‐Rosich Patricia 
Published: February 2020

ObjectiveTo identify clinical predictors of excellent response to OnabotulinumtoxinA in patients with chronic migraine (CM) at 6 and 12 months of follow‐up.BackgroundClinical predictors of response to OnabotulinumtoxinA are scarce and have not been clearly reproduced and analyzed in detail. So far, predictors of response to OnabotulinumtoxinA assess response in general or good response, but not an excellent response.MethodsCohort study of patients attended in a specialized Headache Clinic in treatment with OnabotulinumtoxinA were classified according to their improvement in frequency: no‐response (<25%) and excellent response (≥75%). A comparative analysis was carried out at 6 and 12 months identifying clinical predictors of excellent response to OnabotulinumtoxinA at each timepoint.ResultsData were collected from 221 patients. After 6 and also 12 months, we observed a statistically significant mean reduction in frequency and analgesic intake. At month 6, independent variables associated with excellent response (OR[95%CI]) were daily headache frequency (0.32[0.14‐0.74]; P = .005), medication overuse (MO) (2.28[1.19‐4.37]; P = .013), and a higher ratio of migraine days/month (MDM) (1.20[1.10‐1.45]; P = .018) at baseline. At month 12, independent predictors of excellent response were patients with less than 30 years of migraine evolution (0.43[0.23‐0.82]; P = .011), presence of anxiety (0.44[0.23‐0.85]; P = .018), and aura (0.48[0.25‐0.92]; P = .037). Excellent responders showed a higher improvement rate in pain intensity at 6 and 12 months.ConclusionsPatients with daily frequency and MO show a clinical improvement in short‐term. Patients with comorbidities who start treatment earlier in the course of the disease need a longer duration of treatment. The profile of response to treatment with OnabotulinumtoxinA determines its minimum treatment duration and the timepoint of a meaningful response.