bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scalability of future climate changes across Japan examined with large-ensemble simulations at + 1.5 K, +2 K, and + 4 K global warming levels
Authors: Nosaka Masaya , Ishii Masayoshi , Shiogama Hideo , Mizuta Ryo , Murata Akihiko , Kawase Hiroaki , Sasaki Hidetaka 
Published: June 2020

AbstractLarge-ensemble climate experiments were performed to simulate future climates for a + 1.5 K rise in the global mean surface air temperatures relative to preindustrial levels as a subset of the database for Policy Decision making for future climate change (d4PDF), using the Non-Hydrostatic Regional Climate Model (NHRCM) with 20 km grid spacing. Along with present climate, + 2 K and + 4 K experimental outputs from the d4PDF already available, we investigated responses of surface air temperature (SAT) and precipitation on regional scales over Japan to global warming. The reproducibility of the present climate experiment is satisfactory to investigate future changes in the Japanese climate, and dynamical downscaling from the global to the regional climate states improves the frequency of heavy daily precipitation. In the future, SAT over Japan rises linearly with and faster than the global mean SAT. The meridional contrast of SAT rises becomes more pronounced as global warming progresses. Winter precipitation decreases/increases linearly in the western/eastern Japan, reflected by weakening of future winter monsoons. Annual maximum daily precipitation (R1d) shows a closely linear increase with the global SAT rise, but annual precipitation is mostly unchanged. The global mean SAT change from + 1.5 to + 2 K enhances R1d by 2.7% over the Japanese Islands, although the increase of R1d varies by regions. The increase in R1d is 5% in northern Japan, where the SAT increases are greater than those in other regions.
Relations between serum and pleural fluid biomarkers: a new look of an old concept
Authors: Hussein Sabah Ahmed , Elhefnawy Maha Yousif 
Published: June 2020

AbstractBackgroundAlthough cytological examination of pleural fluid samples can simply diagnose malignant pleural effusion (MPE), this test has many limitations. There are no established biomarkers for accurate diagnosis of MPE. This study investigated the association of serum lactate dehydrogenase (LDH)/pleural fluid adenosine deaminase (ADA) which is the cancer ratio with MPE together with assessment of the utility of combining pleural lymphocyte counts “cancer ratio plus” in diagnosing MPE and to evaluate the ability of these markers in differentiating MPE from tuberculous pleural effusion (TPE).ResultsThis prospective study included 150 individuals who were divided into 3 groups including malignant (n= 94), tuberculous (n= 31), and parapneumonic (n= 25) effusions. It was done during the period from January 2018 to July 2019 to assess the utility of cancer ratio and cancer ratio plus in discrimination between MPE and non-MPE. Serum LDH, cancer ratio, and cancer ratio plus were significantly associated with MPE. Also, age, cancer ratio, and serum LDH to pleural fluid lymphocyte count ratio were positive predictors of MPE. A cutoff level of > 16.02 for the cancer ratio showed sensitivity and specificity of 61% (95% CI 0.5002–0.7056) and 96% (95% CI 0.8769–0.9956) respectively. At this cutoff, the positive likelihood ratio was 16.99, while the negative likelihood ratio was 0.41.ConclusionCancer ratio was found to be more accurate than cancer ratio plus and serum LDH to pleural fluid lymphocyte count ratio in identifying MPE especially in patients with negative pleural fluid cytology.
Systematic Patient Navigation Strategies to Scale Breast Cancer Disparity Reduction by Improved Cancer Prevention and Care Delivery Processes
Authors: Simon Melissa A. , Trosman Julia R. , Rapkin Bruce , Rittner Sarah S. , Adetoro Elizabeth , Kirschner Marcie C. , O’Brian Catherine A. , Tom Laura S. , Weldon Christine B. 
Published: June 2020

PURPOSE: Patient navigation uses trained personnel to eliminate barriers to timely care across all phases of the health care continuum, thereby reducing health disparities. However, patient navigation has yet to be systematized in implementation models to improve processes of care at scale rather than remain a band-aid approach focused solely on improving care for the individual patient. The 4R systems engineering approach (right information and right treatment to the right patient at the right time) uses project management discipline principles to develop care sequence templates that serve as patient-centered project plans guiding patients and their care team. METHODS: A case-study approach focused on the underserved patient shows how facilitators to timely breast cancer screening and care pragmatically identified as emergent data by patient navigators can be actionized by iteratively revising 4R care sequence templates to incorporate new insights as they emerge. RESULTS: Using a case study of breast cancer screening of a low-income patient, we illustrate how 4R care sequence templates can be revised to incorporate emergent facilitators to care identified through patient navigation. CONCLUSION: Use of care sequence templates can inform the care team to optimize a particular patient’s care, while functioning as a learning health care system for process improvement of patient care and patient navigation scaling. A learning health care system approach that systematically integrates data patterns emerging from multiple patient navigation experiences through in-person navigators and 4R care sequence templates may improve processes of care and allow patient navigation scaling to reduce cancer disparities.
Functional Characterization of TMEM127 Variants Reveals Novel Insights into Its Membrane Topology and Trafficking
Authors: Flores Shahida K , Deng Yilun , Cheng Ziming , Zhang Xingyu , Tao Sifan , Saliba Afaf , Chu Irene , Burnichon Nelly , Gimenez-Roqueplo Anne-Paule , Wang Exing , Aguiar Ricardo C T , Dahia Patricia L M 
Published: June 2020

Abstract

Context
TMEM127 is a poorly known tumor suppressor gene associated with pheochromocytomas, paragangliomas, and renal carcinomas. Our incomplete understanding of TMEM127 function has limited our ability to predict variant pathogenicity.

Purpose
To better understand the function of the transmembrane protein TMEM127 we undertook cellular and molecular evaluation of patient-derived germline variants.

Design
Subcellular localization and steady-state levels of tumor-associated, transiently expressed TMEM127 variants were compared to the wild-type protein using immunofluorescence and immunoblot analysis, respectively, in cells genetically modified to lack endogenous TMEM127. Membrane topology and endocytic mechanisms were also assessed.

Results
We identified 3 subgroups of mutations and determined that 71% of the variants studied are pathogenic or likely pathogenic through loss of membrane-binding ability, stability, and/or internalization capability. Investigation into an N-terminal cluster of missense variants uncovered a previously unrecognized transmembrane domain, indicating that TMEM127 is a 4- transmembrane, not a 3-transmembrane domain-containing protein. Additionally, a C-terminal variant with predominant plasma membrane localization revealed an atypical, extended acidic, dileucine-based motif required for TMEM127 internalization through clathrin-mediated endocytosis.

Conclusion
We characterized the functional deficits of several germline TMEM127 variants and identified novel structure–function features of TMEM127. These findings will assist in determining pathogenicity of TMEM127 variants and will help guide future studies investigating the cellular role of TMEM127.
Zinc detection in cosmetics
Authors: Materna Jolanta , Nieradko-Iwanicka Barbara 
Published: June 2020

Zinc is a metal which participates in the control of genetic information transfer, protein biosynthesis, affects the proper structure of the skin and hair, has bactericidal activity, accelerates wound healing, increases resistance to infection. It has an effect on skin regeneration and affects collagen metabolism.The aim of the study was to check it zinc is present in cosmetics.To detect zinc in cosmetics, 0.2 g were weighed into a 25 cm3 beaker. 5 cm3 of an 80% acetic acid solution was added, the beaker was covered with a watch glass and the contents were heated for 5 minutes. The suspension was cooled, poured into a centrifuge tube and centrifuged. The supernatant liquid was poured onto a watch glass, a few drops of Na2S solution were added. The precipitation of the white ZnS precipitate indicated the presence of zinc in the sample.105 samples of cosmetics were collected. The compositions of these cosmetics were analyzed.Zinc and its compounds were enumerated by the manufacturers in the composition of 14 cosmetics collected for the study. Presence of zinc was confirmed in Bell HYPOAllergenic - Powder, Face palette Bronze'n'blush no 14 and 24, Skin79 Super + Beblesh Balm, MaxFactor - Powder, My Secret - eye shadow, Paese - eye shadow , Ziaja med - soothing treatment, Ziaja GdanSkin - hydrogel face, Tołpa dermo face mask, Mixa - Against imperfections mask, The Ordinary serum, Oriflame Royal Velvet - night cream and BeBeauty Care - face mask.Conclusion: Zinc was detected in 14 cosmetics.
Craniofacial disorders in the course of Angelman syndrome - a review of the literature
Authors: Brukiewicz Katarzyna , Komisarek Oskar 
Published: June 2020

Angelman syndrome is a neurogenetic disorder with an estimated prevalence of 1 in 10.000 to 1 in 40.000 cases. Clinical presentation is based on characteristic neurobehavioral and emotional disorders, a function of the nervous and pulmonary system as well as dysmorphic features within craniofacial and neurocranium. The aim of the study is an evaluation based on the literature reviewing disorders in the craniofacial region in patients with Angelman Syndrome, with particular emphasis on the oral cavity. Literature from the PubMed base and the Main Medical Library from the last 30 years was analysed. sixteen items were obtained; after verification, the requirements were met by 16 publications, which together contained a description of the craniofacial and oral cavity disorders in 226 patients. Disorders associated with Angelman syndrome affected many aspects related to health, basic life functions and interpersonal relationships. Proper substantive preparation for working with such a patient enables effective prevention and health monitoring, adjustment of the treatment plan, as well as readiness for any unexpected situations.
Incertidumbre médica, compañera habitual en el cuidado intensivo pediátrico. Análisis a partir de un caso clínico.
Authors: Alvarez-Cabrera Cecilia Adriana 
Published: June 2020

En la complejidad de las unidades de cuidado intensivo pediátrico, en donde confluyen equipo médico, pacientes y familia, la pregunta por lo ético es ineludible, como lo son también, las situaciones de incertidumbre médica. Con el objeto de ofrecer un punto de partida para la comprensión y el manejo de la incertidumbre médica, se narra un caso clínico ficticio que pretende representar la situación, se trata la incertidumbre desde lo teórico, a partir del modelo de la Incertidumbre de Tannert, Elvers, Jandrig (2007), y la propuesta de McCullough (2013) para la resolución moral de la incertidumbre y finalmente, se plantea la resolución del caso desde la perspectiva bioética.
Using femtosecond laser pulses for electronic distance meter calibration
Authors: Hussein Haitham M. , Terra Osama , Hussein Hatem , Medhat Mohamed 
Published: June 2020

Electronic distance meters (EDMs) are widely used in different applications, such as surveying and civil engineering. In order to calibrate an EDM, different techniques can be used, including displacement interferometers and reference baselines. In this paper, an indoor baseline is designed and then accurately measured using femtosecond laser pulses from an optical frequency comb to be used for EDM calibration. The baseline consists of 13 fixed bases that cover 58 m distance. In order to accurately measure the distances between the bases, autocorrelation between femtosecond laser pulses is employed. The measurement shows a maximum precision of 14 µm over the 13 bases. Although this deviation is dominated mainly by the placement of the target mirror, the system capability is much more sufficient to safely calibrate the best available commercial EDM. The stability of the baseline is also investigated by measuring the interbase distances over long periods of time.
Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
Authors: Mazlin Viacheslav , Irsch Kristina , Paques Michel , Sahel Jose-Alain , Fink Mathias , Boccara Claude A. 
Published: June 2020

Cell-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers, and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in vivo and achieve a

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larger viewing area comparing to the clinical state-of-the-art. This enables more precise cell and nerve counts, opening a path to improved monitoring of corneal and general health conditions (e.g., diabetes). The method is non-contact, compact, and works in a single fast shot (3.5 ms), making it readily available for use in optical research and clinical practice.
Adenocarcinoma Within Carpet-Like Pseudopolyposis
Authors: Xiao Yasi , Lakatos Peter L. , Bessissow Talat 
Published: June 2020

ABSTRACT
Pseudopolyps are benign lesions without malignant potential and typically do not require biopsy or excision. We describe a 68-year-old man with ulcerative colitis found to have multiple large bridging pseudopolyps. Repeated colonoscopies and extensive biopsies revealed a large ulcerated lesion previously hidden within the pseudopolyps. The pathology of the lesion was consistent with a low-grade adenocarcinoma with invasion into the muscularis propria. This demonstrates that large pseudopolyps, although benign, can obscure other lesions with malignant potential. Therefore, in addition to careful inspection, healthcare providers must perform periodic surveillance colonoscopies and offer surgical resection to patients with giant pseudopolyposis.
Ocena odnosa medicinskih sester do pacienta v forenzični psihiatriji
Authors: Cerar Vanda , Bregar Branko 
Published: June 2020

Uvod: Forenzična psihiatrija obravnava ranljivo skupino pacientov. Paciente zaznamuje »več stigmatizirana identiteta«, ki vključuje stigmatiziranje duševne motnje, po drugi strani pa tudi stigmatiziranje kriminalnega dejanja, ki ga je oseba storila. Namen raziskave je bil raziskati poznavanje in odnos zaposlenih v zdravstveni negi do pacienta v forenzični psihiatriji.Metode: Izvedli smo opisno neeksperimentalno kvantitativno raziskavo. Vprašalnik je bil razdeljen priložnostnemu vzorcu 320 zaposlenih v zdravstveni negi na področju psihiatrije in izven psihiatrične stroke, realizacija je bila 74,4 % (n = 238).Rezultati: Anketiranci so obravnavo na področju forenzične psihiatrije poznali povprečno (x = 3,04, s = 1,17). Zaposleni izven psihiatrije (n = 55, = 5,72, s = 2,57) so izražali bolj odklonilen odnos (U = 838,50, p < 0,001) kot zaposleni v psihiatriji (n = 66, x = 7,53, s = 2,17), prepoznavali več negativnih značilnosti pacienta (U = 115,000, p = 0,043) in izražali več stigme (U = 1218,000, p = 0,002).Diskusija in zaključek: Zaposlene na področju psihiatrije je manj strah, gojijo manj stigme in bolj poznajo področje forenzične psihiatrije. Ker so poznavanje, strah in prisotna stigma povezani s kakovostjo zdravstvene obravnave, je treba zaposlene usposobiti za delo z ranljivimi skupinami prebivalstva, kot so pacienti v forenzični psihiatriji. Tako lahko nudijo bolj kakovostno zdravstveno obravnavo.
Vpliv medpoklicnega izobraževanja medicinskih sester na njihovo medpoklicno sodelovanje
Authors: Kamenšek Tina , Kavčič Matic , Domajnko Barbara 
Published: June 2020

Uvod: Oskrba pacientov je kompleksna in zahteva učinkovito sodelovanje različnih profilov zdravstvene in socialne oskrbe. Medpoklicno izobraževanje je lahko uspešen način izboljševanja medpoklicnega sodelovanja in oskrbe pacienta. Namen pregleda literature je bil preučiti vpliv medpoklicnega izobraževanja medicinskih sester na njihovo medpoklicno sodelovanje z drugimi profili v zdravstvu in identificirati morebitne merske instrumente za preučevanje tega vpliva.Metode: S sistematičnim pregledom literature so bili pregledani znanstveni članki, objavljeni med letoma 2011 in 2018, navedeni v bibliografskih bazah CINAHL, MEDLINE in PubMed Central. Proučevani so bili članki, ki so obravnavali zaposlene in študente zdravstvene nege, ki so se medpoklicno izobraževali in tudi sodelovali z drugimi profili zdravstvene in socialne oskrbe pacientov.Rezultati: Izmed 1277 identificiranih objav je bilo v končno analizo vključenih devet virov. Sedem raziskav je poročalo o tem, da je bilo po medpoklicnem izobraževanju medpoklicno sodelovanje boljše, večja sta bila tudi medsebojno spoštovanje vključenih in medpoklicna samozavest, izboljšano pa pozitivno mišljenje o vlogi soudeleženih poklicev pri zdravstveni oskrbi. Dve raziskavi sta nasprotno poročali, da medpoklicno izobraževanje ne vpliva na zgoraj navedene dejavnike. Ugotovljena je bila prisotnost različnih merskih instrumentov za ocenjevanje vpliva medpoklicnega izobraževanja na medpoklicno sodelovanje.Diskusija in zaključek: Rezultati potrjujejo smiselnost vpeljave medpoklicnega izobraževanja v redni del študijskih programov zdravstvene nege. V prihodnje bi bila potrebna obsežnejša longitudinalna raziskava, ki bi preučevala medpoklicno izobraževanje medicinskih sester in potrdila njegov vpliv na medpoklicno sodelovanje v praksi.
Automatic target recognition method for multitemporal remote sensing image
Authors: Shu Chang , Sun Lihui 
Published: June 2020

AbstractThe traditional target recognition method for the remote sensing image is difficult to accurately identify the specified targets from the massive remote sensing image data. Based on the theory of multitemporal recognition, an automatic target recognition method for the remote sensing image is proposed in this article. The proposed recognition method includes four modules: automatic segmentation of multitemporal remote sensing image, automatic target extraction of multitemporal remote sensing image, automatic processing of multitemporal remote sensing image, and automatic recognition of multitemporal remote sensing image. The automatic segmentation of the image target is introduced. The effectiveness of the segmentation technology is verified through the kernel function bandwidth algorithm. Linear feature extraction is used to extract the segmented image. The image extraction processing is described, which includes image profile analysis, image preprocessing, image feature analysis, the region of interest localization, image enhancement processing, recognition processing, and result output. According to the theory of pattern recognition, three different feature recognition images are given, which are partial separable recognition, weakly separable recognition, and fully separable recognition, and then, a new image recognition method is designed. To verify the practical application effect of the recognition method, the proposed method is compared with the traditional recognition method. Experimental results show that the proposed method can accurately identify the specified objects from the massive remote sensing image data and has a high potential for development. This article has an important guiding significance for image recognition.
Dynamic response characteristics of 93W alloy with a spherical structure
Authors: Zhao Taiyong , Wang Weizhan , Chen Zhigang , Feng Shunshan , Yin Likui , Fu Jianping , Cheng Lele , Yang Shuai 
Published: June 2020

AbstractTo study the dynamic response characteristics of 93W alloy spherical component under high overload, the deformation patterns of the 93W spherical component under different overloads are obtained by the sphereistic impact test, and the microscopic response characteristics are studied by the metallographic analysis experiments. Finally, the response characteristics are analyzed by the finite element method and the stress wave theory. The results show that with the change of impact overload, the axial direction of the 93W spherical component changes linearly with the radial deformation, and the axial strain increases with the increase of the impact overload. At the same time, along the radial direction from the center of the sphere, the micrograin distribution of 93W appears densely packed and sparsely separated, and the grain density is uniformly changed between dense area and sparse area, showing a ring-shaped “bright band” phenomenon between light and dark, and the width of the “bright band” is related to the size of the dense area of the grain; with the increase of the impact overload, the 93W alloy component first breaks at the central axis and the radial maximum position, and the fracture mode changes from the crystal fracture to the transgranular fracture tendency, and the two fracture forms eventually coexist.
The Role of Listing Price Strategies on the Probability of Selling a House: Evidence from Vietnam
Authors: Bich Hong Nguyen Thi , Trong Hoai Nguyen , Thanh Hiep Truong 
Published: June 2020

AbstractThe aim of this paper is to measure the dynamic effects of listing price strategies and housing features on the probability of selling a house over the marketing period by adopting a two-stage regression analysis. In the first stage, we define the listing price strategies as the gaps between the actual listing price and expected selling price, estimated by a hedonic model. The Cox Probability Hazard models are applied in the second stage to measure the effects of listing price strategies on the probability of sales over various listing periods, such as 30-day, 90-day, 180-day and 270-day listing periods.We find that overpriced listing strategies have a significant impact on the probability of sale at any point during the first 30 days of marketing time. This effect seems to diminish and disappear after six months of marketing time. This shows that the first 30 days of the marketing time are critical and housing liquidity is strongly affected by pricing strategies. When the time on market is over 30 days, the influence of the seller’s pricing decisions on housing liquidity is diminished.
Mammalian exocrine secretions XIX. Chemical characterization of the interdigital secretion of the Black Wildebeest, Connochaetes gnou
Authors: Burger Barend V. , Slade Desmond , Bekker Marlize Z. , Goitom Aron H. 
Published: June 2020

Abstract
Using gas chromatography (GC) in conjunction with electron impact mass spectrometry and retention-time comparison, 94 compounds, ranging from 2-methyl-2-propenal to octadecanoic acid, were identified in the interdigital secretions of male and female black wildebeests, Connochaetes gnou (also known as the white-tailed gnu). The constituents of these secretions belong to many different compound classes, including hydrocarbons, alcohols, aromatics and aliphatic carbonyl compounds including carboxylic acids as well as carboxylic acid esters. Relatively small quantitative differences were found between the male and female interdigital secretions. It was concluded that these compounds probably do not play a significant role in territorial marking or in chemical communication between males and females of the species, but they could be involved in preserving the remarkably strong attachment between members of social subgroups in black wildebeest populations.