bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serving ‘the Cause’: Cecil Jackson-Cole and the professionalization of charity in post-war Britain*
Authors: Field Jessica 
Published: February 2020

Abstract
This article explores the relationship between faith, business and charity in mid to late twentieth-century Britain by examining the work of Cecil Jackson-Cole, co-founder of Oxfam, founder of Help the Aged, ActionAid and many other charities. Jackson-Cole’s approach to ‘building-up’ a charity accelerated the ongoing professionalization of the sector. This did not, however, represent a complete break from the Christian charity ethos of the past. By examining Jackson-Cole’s faith and its influence on his charity business network and practices, it is possible to see an enduring symbiotic relationship between faith and professionalization in organized charity across the twentieth century.
Genetic predisposition to coronary artery disease is predictive of recurrent events: a Chinese prospective cohort study
Authors: Jiang Jie , Zheng Qiwen , Han Yaling , Qiao Shubin , Chen Jiyan , Yuan Zuyi , Yu Bo , Ge Lei , Jia Jia , Gong Yanjun , Wang Zhi , Chen Dafang , Zhang Yan , Huo Yong 
Published: February 2020

Abstract
Evidence of the effects of genetic risk score (GRS) on secondary prevention is scarce and mixed. We investigated whether coronary artery disease (CAD) susceptible loci can be used to predict the risk of major adverse cardiovascular events (MACEs) in a cohort with acute coronary syndromes (ACSs). A total of 1667 patients hospitalized with ACS were enrolled and prospectively followed for a median of 2 years. We constructed a weighted GRS comprising 79 CAD risk variants and investigated the association between GRS and MACE using a multivariable cox proportional hazard regression model. The incremental value of adding GRS into the prediction model was assessed by integrated discrimination improvement (IDI) and decision curve analysis (DCA). In the age- and sex-adjusted model, each increase in standard deviation in the GRS was associated with a 33% increased risk of MACE (hazard ratio: 1.33; 95% confidence interval: 1.10–1.61; P = 0.003), with this association not attenuating after further adjustment for traditional cardiovascular risk factors. The addition of GRS to a prediction model of seven clinical risk factors and EPICOR prognostic model slightly improved risk stratification for MACE as calculated by IDI (+1.7%, P = 0.006; +0.3%, P = 0.024, respectively). DCA demonstrated positive net benefits by adding GRS to other models. GRS was associated with MACE after multivariable adjustment in a cohort comprising Chinese ACS patients. Future studies are needed to validate our results and further evaluate the predictive value of GRS in secondary prevention.
Impact of pulmonary artery reduction during arterial switch operation: 14 years follow-up
Authors: Lübe Antunes Pereira Fernanda , Nunes Martins Cristiane , Lopes Roberto Max , Ferber Drummond Matheus , Fantini Fernando Antonio , Correa Vrandecic Erika , Vrandecic Peredo Mario Oswaldo , Gontijo Filho Bayard 
Published: February 2020

Abstract

OBJECTIVES
Pulmonary artery/aorta (PA/Ao) size discrepancy plays an important role in the development of neoaortic root growth and valve regurgitation. Since 2004, we started using PA reduction to manage severe great vessels root mismatch at the time of arterial switch operation. The purpose of this study is to evaluate the impact of this technique in the mid- and long-term follow-up.

METHODS
Patients considered to have severe PA/Ao mismatch (&gt;2:1 ratio) underwent resection of a 3- to 4-mm flap of the posterior PA wall. Patients submitted to this technique were followed up with clinical and image examinations. Echocardiographic findings were reviewed, and Z-scores were recorded to evaluate the incidence and progression of neoaortic root dilatation and valve regurgitation.

RESULTS
The median (Q1–Q3) follow-up time was 8 years (3–11). Before arterial switch operation, the median (Q1–Q3) Z-score of the PA annulus was 2.90 (2.75–3.75). At the latest follow-up, the median Z-score of the neoaortic annulus was 1.34 (0.95–1.66). The mean difference between the Z-scores of PA annulus and neoaortic annulus was 1.56 (P &lt; 0.0001). The mean value of the sinus of Valsalva was +0.29 ± 1, that of sinotubular junction was +0.71 ± 0.6 and that of ascending Ao was +1.09 ± 0.7. There was no severe dilatation of the neoaortic annulus, neoaortic root or ascending Ao during follow-up. Neoaortic valve regurgitation was none or mild in 93% of patients.

CONCLUSIONS
PA reduction proved to be a feasible and low-risk procedure to approach PA/Ao mismatch in arterial switch operation. Mid- and long-term follow-up showed a tendency towards stabilization of the neoaortic root dilatation and satisfactory valve performance after the procedure. Further investigation is required with a larger population and longer-term follow-up.
A statistical primer on subgroup analyses
Authors: Milojevic Milan , Nikolic Aleksandar , Jüni Peter , Head Stuart J 
Published: February 2020

Abstract

Resources for clinical research are limited. With increasing demand for patient-centred care, which is growing into an integral component of modern medicine, studying outcomes of patients with specific clinical characteristics is becoming increasingly important. Given the high cost of clinical trials and the time it takes to complete an investigation, it has become compulsory for investigators to assess not only treatment effects between the main randomized groups but also to try to identify clinically relevant subgroups that may particularly benefit from specific treatments. Publications of subgroup analyses turned out to be prevalent, and more importantly, these findings play a significant role in strategic planning and decision-making processes. Therefore, raising awareness among clinicians about the concepts and values of subgroup analysis is an aspect of improving patient outcomes. In this statistical primer, we give a broad introduction to the topic of subgroup analysis in scientific research. We furthermore discuss the concept of subgroup analysis; the motivation for assessing subgroups; the types of subgroup analyses and the paradigm of hypothesis-generating research; the proper statistical methods for the examination of subgroup effects; and the optimal approach for interpretation of results. Finally, this review establishes the comprehensive users’ guide for analysing and reporting subgroup studies on a point-by-point basis, using real-world examples that may help readers to gain experience to pursue their own subgroup analyses or interpret those of others.
Detection of Zika Virus Replication in Human Semen by Reverse-Transcription Polymerase Chain Reaction Targeting of Antisense Ribonucleic Acid
Authors: Huits Ralph , De Smet Birgit , Grard Gilda , Eggermont Kaat , Minto-Bain Catherine , Jess Natalie , Leparc-Goffart Isabelle , Malvy Denis , Cnops Lieselotte 
Published: February 2020

Abstract

Background
Persistence of Zika virus (ZIKV) ribonucleic acid (RNA) in semen is common after infection.

Methods
We designed a reverse-transcription polymerase chain reaction assay that targets antisense ZIKV RNA (asRNA) to assess ZIKV replication competence in ZIKV RNA-positive semen samples.

Results
We detected ZIKV asRNA in semen of 9 of 19 men (47.4%) diagnosed with ZIKV infection. All asRNA-positive samples had high ZIKV loads (cycle threshold values &lt;26) and were obtained within 21 days of symptom onset.

Conclusions
The sensitivity of the asRNA assay for detection of ZIKV replication was higher than that of conventional virus isolation methods (47.4% vs 21.1%, P = .032).
Confronting the International Political Sociology of the New Right
Authors: Abrahamsen Rita , Drolet Jean-François , Gheciu Alexandra , Narita Karin , Vucetic Srdjan , Williams Michael 
Published: February 2020

AbstractThe rise of radical right-wing leaders, parties, movements, and ideas have transformed not only domestic political landscapes but also the direction and dynamics of international relations. Yet for all their emphasis on nationalist identity, on “America First” and “Taking Back Control,” there is an unmistakable international dimension to contemporary nationalist, populist movements. Yet these movements are also often transnationally linked. We argue that a constitutive part of this globality is the New Right's (NR) own distinctive international political sociology (IPS). Key thinkers of the contemporary NR have, over several decades, theorized and strategically mobilized globalized economic dislocation and cultural resentment, developing a coherent sociological critique of globalization. Drawing on the oft-neglected tradition of elite managerialism, NR ideologues have borrowed freely from Lenin and Schmitt on the power of enmity, as well as from Gramsci and the Frankfurt School on counterhegemonic strategies. Against the temptation to dismiss right-wing ideas as “merely” populist and by implication as lacking in ideological and theoretical foundations, we are faced with the much more challenging task of engaging a position that has already developed its own international political sociology and incorporated it into its political strategies.
Immunoaffinity Column Cleanup with Liquid Chromatography Using Post-Column Bromination for Determination of Aflatoxins in Peanut Butter, Pistachio Paste, Fig Paste, and Paprika Powder: Collaborative Study
Authors: Stroka Joerg , Anklam Elke , Jörissen Urban , Gilbert John ,   Collaborators:, Barmark Anna , Brera Carlo , Clasen Per-Erik , Galagher Fiona , Gardikis John , Jensen Lene Bai , Lee Fiona , Luz Macho , Michelet Jean-Yves , Noutio Kirsti , Palvras Lizete , Pittet Alain , Reutter Matthias , Scholten Jos M , Strassmeier Elfriede , Szymanski Louis 
Published: February 2020

Abstract
A collaborative study was conducted to evaluate the effectiveness of an immunoaffinity column cleanup liquid chromatography (LC) method for the determination of aflatoxin B1 and total aflatoxins at European regulatory limits. The test portion is extracted with methanol–water (8 + 2) for dried figs and paprika, and with methanol–water (8 + 2) plus hexane (or cyclohexane) for peanut butter and pistachios. The sample extract is filtered, diluted with phosphate buffer saline, and applied to an immunoaffinity column. The column is washed with water and the aflatoxins are eluted with methanol. Aflatoxins are quantitated by reversed-phase LC with post-column derivatization (PCD) involving bromination. PCD is achieved with either an electrochemical cell (Kobra cell) and addition of bromide to the mobile phase or pyridinium hydrobromide perbromide. Determination is by fluorescence. Peanut butter, pistachio paste, dried fig paste, and paprika powder samples, both naturally contaminated with aflatoxins and containing added aflatoxins, were sent to 16 collaborators in 16 European countries. Test portions of samples were spiked at levels of 2.4 and 9.6 ng/g for total aflatoxins which included 1.0 and 4.0 ng/g aflatoxin B1, respectively. Recoveries for total aflatoxins ranged from 71 to 92% with corresponding recoveries for aflatoxin B1 of 82 to 109%. Based on results for spiked samples (blind duplicates at 2 levels) as well as naturally contaminated samples (blind duplicates at 4 levels, including blank), the relative standard deviation for repeatability ranged from 4.6 to 23.3% for total aflatoxins and from 3.1 to 20.0% for aflatoxin B1. The relative standard deviation for reproducibility ranged from 14.1 to 34.2% for total aflatoxins, and from 9.1 to 32.2% for aflatoxin B1. The method showed acceptable within-laboratory and between-laboratory precision for all 4 matrixes, as evidenced by HORRAT values &lt;1, at the low levels of determination for both total aflatoxins and aflatoxin B1.
Determination of Lithium in Human Serum by Electrothermal Atomic Absorption Spectrometry
Authors: González Sara , Navarro Miguel , López Herminia , López María C , Pérez Vidal 
Published: February 2020

Abstract
An efficient method was developed for the determination of nanogram levels of lithium in biological samples. Serum samples from human subjects from southeastern Spain, treated or not treated with lithium carbonate, were analyzed by electrothermal atomic absorption spectrometry. The samples were previously treated with a matrix modifier consisting of 0.1%Triton X-100 and injected through a graphite tube with L'vov platform. The Li concentrations measured by the procedure described for the 3 certified reference samples used were not significantly different (p &gt; 0.05) than certified levels. Sample recoveries and variability during several days, with coefficients of variation from 4.00 to 14.8%, demonstrated the reliability and accuracy of this technique. Mean Li concentration determined in the serum of individuals with psychiatric disorders treated with Li (n = 117, 5.077 ± 1.795 μg Li/mL) was significantly higher (p &lt; 0.001) than that in individuals not treated with Li (n = 24, 1.902 ± 2.054 ng Li/mL).
Determination of Hydroperoxides in Liposomes by the Modified IDF and the Modified Tiron Methods
Authors: Gabriëls Margriet , Cirunay Joyce , Alafandy Mokarram , Brisaert Myriam , De Taevernier Marc , Camu Frederik , Plaizier-Vercammen Jacqueline 
Published: February 2020

Abstract
Two new methods, the modified International Dairy Federation and the modified Tiron methods, were developed for the determination of hydroperoxides in liposomes. Interferences of α-tocoferol and egg-phosphatidylcholine (EPC) required a solid-phase extraction before the analysis to eliminate α-tocoferol and a fluid–fluid extraction based on the solvent triangle of Bligh and Dyer to separate EPC. The developed color, using thiocyanate and Tiron, respectively, as complexformers for the generated ferri-ions, was measured spectrophotometrically. Both techniques showed good reproducibility and high sensitivity. Peroxide contents of 0.04 and 0.07% (g/g) in EPC samples were easily determined.
Determination of Inulin in Foods
Authors: Simonovska Breda 
Published: February 2020

Abstract
A method was developed for determining fructan inulin in various foods (yogurts, honey cakes, chocolates). Warm water was applied for extraction of samples, and mono- and dissacharides were determined by a thin-layer chromatographic densitometric method. A portion of the test solution was hydrolyzed 30 min with 1% oxalic acid in a boiling water bath. Fructose was determined in the hydrolysate. The amount of inulin in a sample was calculated as the difference between the amount of fructose in the sample before and after hydrolysis. The fructose from sucrose formed during the hydrolysis was also considered. The mean recovery from yogurt fortified with 4% inulin was 95.5 ± 4.5% (mean ± standard deviation); from honey cakes extract fortified with 10% inulin, 97.3 ± 5.5%; and from chocolate extract fortified with 30% inulin, 98.6 ± 6.6% (6 replicates in all cases). Determination of glucose is not necessary for analyzing fructans with the composition expressed shortened to GFn−1 (G, glucose; F, fructosyl) with the average degree of polymerization 8 ≤ n ≤ 15.
Selective Trace Determination of Dithiocarbamate Fungicides in Fruits and Vegetables by Reversed-Phase Ion-Pair Liquid Chromatography with Ultraviolet and Electrochemical Detection
Authors: Lishaut Holger Van , Schwack Wolfgang 
Published: February 2020

Abstract
The predominant methods for determination of dithiocarbamate fungicides (DTC) have been based on quantitation of carbon disulfide released by hot acid digestion. Because the subgroups of the DTC family differ in their chemical properties and toxicological behavior, selective determination is required. To meet the demand for a fast, simple, and sensitive procedure, a new reversed-phase ion-pair chromatographic method was developed, consisting of surface extraction followed by direct injection into a liquid chromatographic system equipped with ultraviolet and electrochemical detectors, connected in series. The procedure is applicable to residues of N-methyldithiocarbamates (metam-sodium), N,N-dimethyldithiocarbamates (e.g., ziram and ferbam), ethylenebisdithiocarbamates (e.g., nabam, maneb, zineb, and mancozeb), and propylenebisdithiocarbamates (e.g., propineb) in fruits and vegetables. Limits of quantitation, calculated according to the procedure of the Deutsche Forschungsgemeinschaft, are 9, 12, 8, and 12 μg CS2/L for N-methyl-DTC, N,N-dimethyl-DTC, ethylenebis-DTC, and propylenebis-DTC, respectively, when electrochemical detection is used.
Determination of Residues of Pirimicarb and Its Desmethyl and Desmethylformamido Metabolites in Fruits and Vegetables by Liquid Chromatography–Electrospray/Mass Spectrometry
Authors: Startin James R , Sykes Mark D , Taylor John C , Hird Simon J , Jackson Kirsty , Fussell Richard J , Hill Alan R C 
Published: February 2020

Abstract
A method was developed for the simultaneous determination of residues of pirimicarb (I) and its desmethylformamido (II) and desmethyl (III) metabolites in plums, peas, green beans, broad beans, carrots, and swedes. The compounds were extracted with ethyl acetate and determined, without cleanup, by reversed-phase liquid chromatography and electrospray mass spectrometry (MS). MS and MS/MS were used concurrently to monitor the protonated molecules and their common collision-induced dissociation product. The limit of detection (signal-to-noise ratio of &gt;3) was 1 ng/mL, corresponding to crop concentrations of &lt;0.0015 mg/kg. All 3 compounds were determined in plums, broad beans, and green beans by MS without interference. Interferences which affected the determination of desmethylformamido-pirimicarb in peas, and to a lesser extent in carrots and swedes, were eliminated by MS/MS. Recoveries for all 3 compounds, at 0.05 mg/kg for plums and 0.005 mg/kg for other commodities, were in the range 83–124%. No interconversion of I, II and III, occurred during extraction, and the compounds were stable in extracts for ≥7 days under appropriate conditions.
Rapid Ultraviolet Spectrophotometric and Liquid Chromatographic Methods for the Determination of Natamycin in Lactoserum Matrix
Authors: Capitán-Vallvey Luis Fermin , Checa-Moreno Ramon , Navas Natalia 
Published: February 2020

Abstract
Two rapid and simple methods were developed for the determination of natamycin in lactoserum matrix by ultraviolet (UV) spectrophotometry and liquid chromatography (LC) with diode-array detection. The methods involve protein precipitation with methanol, followed by centrifugation. No cleanup is necessary. The applicable concentrations of natamycin in lactoserum range from 2 to 500 mg/L for samples analyzed by both methods. The detection and quantitation limits are 0.07 and 0.23 mg/L, respectively, for the UV spectrophotometric method and 0.1 and 0.32 mg/L, respectively, for the LC method. The methods were applied satisfactorily to the determination of natamycin in various commercial lactosera. Both methods were validated independently by standard additions and Youden methodologies, which verified their accuracy. Once the 2 proposed methods were validated independently, the validation of one method was carried out with the other.
Synthesis of the O-(2,3,4,5,6-Pentafluorobenzyl)Hydroxylamine Oximes of Selected Carbonyl Compounds and Their Determination by Liquid Chromatography with Ultraviolet Detection
Authors: Wiesenthal Karina , Jehlar Alexander , Que Hee Shane S 
Published: February 2020

Abstract
The aims were to develop a liquid chromatographic (LC) method with ultraviolet detection (UVD) for O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) O-oximes of common aldehydes and ketones, and to define the steric limits of the synthetic reaction used to make the PFBHA O-oxime standards for gas chromatographic (GC) and LC methods. Ten new O-oximes were synthesized with the new optimized method, and their purities were demonstrated by GC/electron-capture detection (ECD), GC/mass spectrometry (MS), ultraviolet spectroscopy, infrared spectroscopy, and proton and 13C-nuclear magnetic resonance spectroscopy. Ketones substituted at both β-carbons relative to the carbonyl carbon, like diisobutyl ketone and 2,4-hexanedione, showed lower synthetic yields by wet chemistry methods. A new C18 reverse-phase LC method with UVD at 200 nm and acetonitrile–water in both the isocratic and gradient-elution modes was then developed to sensitively resolve a mixture of 13 pure PFBHA O-oximes. The detection limit was near 100 ng O-oxime/mL or about 14–50 ng aldehyde/mL and the least quantifiable limits were near 500 ng/mL or about 70–250 ng aldehyde/mL, with lower limits for glyoxal, methylglyoxal, benzaldehyde, and acetophenone. Carbonyl compounds in 500 mL water samples were then determined in distilled water and tap water by gradient elution. Vapors of n-valeraldehyde and acrolein generated in gas bags at concentrations near occupational guidelines were also sampled, desorbed, and then determined by either isocratic or gradient elution at 200 or 254 nm within 30–45 min.
What is Dietary Fiber?
Authors: Prosky Leon 
Published: February 2020

Abstract
Dietary fiber consists of the remnants of the edible plant cell, polysaccharides, lignin, and associated substances resistant to digestion (hydrolysis) by human alimentary enzymes. This physiological definition has been translated into a chemical method (AOAC Method 985.29), which has recently been shown to miss substances of 10, 11, and 12 degrees of polymerization. It also fails to precipitate some hydrolysis-resistant oligosaccharides which contain many physiological properties expected in dietary fiber, such as inulin and oligofructose, indigestible dextrin (Fibersol-2™), galactooligosaccharides and the synthetic polymer polydextrose. The Executive Board of the American Association of Cereal Chemists has appointed a committee to explore the possibility of expanding the definition or chemical methodology for dietary fiber to accommodate components that are not hydrolyzed by human alimentary enzymes, yet have the physiological attributes normally associated with dietary fiber. However, the present review suggests that the current definition is sufficient, along with new methodology, to detect recently discovered components of the dietary fiber complex.