bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the transitioning of pediatric patients with type 1 diabetes into adult care by initiating a dedicated single session transfer clinic
Authors: Williams Sarah , Newhook Leigh Anne Allwood , Power Heather , Shulman Rayzel , Smith Sharon , Chafe Roger 
Published: June 2020

Abstract
Background
Young adults with type 1 diabetes face potential health problems and disruptions in accessing care related to their move from pediatrics into adult care. At a medium-sized pediatric hospital with no formal transition support program, we developed and evaluated the use of a single-session transfer clinic as an initial quality improvement intervention to improve patient satisfaction, clinic attendance, and knowledge of transition related issues.

Methods
Following a jurisdictional scan of other diabetes programs, the pediatric diabetes program developed a half-day transfer clinic. After the first transfer clinic was held, evaluation surveys were completed by patients, parents, and healthcare providers. Based on the feedback received, we altered the structure and evaluated the revised clinic by surveying patients and parents.

Results
All patients and parents who attended reported high levels of satisfaction with the clinic. Providers were also mostly positive regarding their participation. Feedback from the first clinic was used to modify the structure of the second clinic to better meet the needs of participants and to allow the clinic to run more efficiently. The use of group sessions and adapting resources developed by other diabetes programs were viewed favourably by participants and lessened the burden on staff who delivered the clinic.

Conclusions
A half-day transfer clinic is a viable step towards improving patient and parent satisfaction during the transition into adult care without requiring additional staff or significant expenditures of new resources. This type of clinic can also be incorporated into a larger program of transition supports or be adopted by programs serving young adults with other chronic diseases.
Sea anemones (Exaiptasia pallida) use a secreted adhesive and complex pedal disc morphology for surface attachment
Authors: Clarke Jessica L. , Davey Peter A. , Aldred Nick 
Published: June 2020

Abstract
Background
The mechanism by which sea anemones attach to surfaces underwater remains elusive, which is surprising given their ubiquitous distribution in the world’s oceans and tractability for experimental biology. Their adhesion is mechanically interesting, bridging the interface between very hard and soft materials. The Cnidaria are thought to have evolved adhesion to surfaces at least 505 Ma ago implying that, among the Metazoa, only Porifera developed this capability earlier. The purpose of this study was primarily to address an existing hypothesis, that spirocysts (a sticky class of cnidocyst) facilitate adhesion to surfaces, as observed during prey capture.

Results
We demonstrated conclusively that spirocysts were not involved in the pedal disc adhesion of Exaiptasia pallida. Second, we applied a variety of imaging methods to develop an understanding of the true adhesion mechanism. Morphological studies using scanning electron microscopy identified a meshwork of adhesive material, unique to the pedal disc. Serial block-face SEM highlighted four classes of cells that could secrete the adhesive from the pedal disc ectoderm. A variety of histochemical techniques identified proteins, glycans and quinones in the cell contents and secreted adhesive, with variation in contents of specific cell-types in different areas of the body.

Conclusions
Spirocysts are not used by Exaiptasia pallida for adhesion to surfaces. Instead, a structurally and compositionally complex secreted glue was observed, firmly attaching the animals underwater. The results of this study provide a basis for further investigations of adhesion in Cnidaria, and establish E. pallida as a new model organism for bioadhesion research.
Evidence from ileum and liver transcriptomes of resistance to high-salt and water-deprivation conditions in camel
Authors: Zhang Dong , Pan Jing , Zhou Huanmin , Cao Yu 
Published: June 2020

AbstractCamels have evolved various resistance characteristics adaptive to their desert habitats. In the present study, we used high-throughput sequencing to investigate stress-induced alternative splicing events as well as different genes involved in resistance to water deprivation and salt absorption in the ileum and liver inCamelus bactrianus. Through association analyses of mRNA, miRNA and lncRNA, we sought to explicate how camels respond to high salt and water scarcity conditions. There were two modes by which genes driven by alternative splicing were enriched to molecular functions, invoking of which was potentially fixed by organ and stress types. With qRT-PCR detection, the differentially expressedMUC6,AQP5,LOC105076960,PKP4,CDH11,TENM1, SDS,LOC105061856,PLIN2andUPP2were screened as functionally important genes, along with miR-29b, miR-484, miR-362-5p, miR-96, miR-195, miR-128 and miR-148a. These genes contributed to cellular stress resistance, for instance by reducing water loss, inhibiting excessive import of sodium, improving protective barriers and sodium ion homeostasis, and maintaining uridine content. The underlying competing endogenous RNAs referred to LNC001664, let-7e andLOC105076960mRNA in ileum, and LNC001438, LNC003417, LNC001770, miR-199c andTENM1mRNA in liver. Besides competent interpretation to resistance, there may be inspirations for curing human diseases triggered by high-salt intake.
Social isolation and loneliness among older adults in the context of COVID-19: a global challenge
Authors: Wu Bei 
Published: June 2020

AbstractWe are experiencing a historical moment with an unprecedented challenge of the COVID-19 global pandemic. The outbreak of COVID-19 will have a long-term and profound impact on older adults’ health and well-being. Social isolation and loneliness are likely to be one of the most affected health outcomes. Social isolation and loneliness are major risk factors that have been linked with poor physical and mental health status. This paper discusses several approaches that may address the issues of social isolation and loneliness. These approaches include promoting social connection as public health messaging, mobilizing the resources from family members, community-based networks and resources, developing innovative technology-based interventions to improve social connections, and engaging the health care system to begin the process of developing methods to identify social isolation and loneliness in health care settings.
Enhanced alcohol degradation and hepatic protective effects of an Acetobacter Pasteurianus-derived product, CureZyme-ACE, in an acute intoxication rat model
Authors: Jeon Eun-Jong , Cho Yun-Sang , Kim Ae-Hyang , Shim Jae-Min , Kim Yi-Soo , Piao Zhe , Shin Young Chul , Kwon Jungkee 
Published: June 2020

AbstractExcessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute intoxication rats. The ethanol and acetaldehyde levels of serum were lower in rats treated with CA than those who only treated ethanol. The activities of alcohol dehydrogenase and acetaldehyde dehydrogenase also recovered faster in the CA group than only-ethanol group. The transaminase levels (AST, ALT) in the CA group were significantly lower than only-ethanol group. In addition, Hepatic histological analyses and stomach wall were demonstrated that the CA-treated group recovered faster than only-ethanol group. With regard to most characteristics, we found that CA had dose-dependent effects. At high concentrations of CA, there were no differences in the tested parameters compared to those of normal rats. These findings indicate that CA reduces the serum alcohol concentration and some of the hepatic damage caused by alcohol intoxication.
Are EMS bypass policies effective implementation strategies for intravenous alteplase for stroke?
Authors: Harris Alex H. S. , Barreto Nicolas B. , Trickey Amber W. , Bereknyei Sylvia , Meng Tong , Wagner Todd H. , Govindarajan Prasanthi 
Published: June 2020

Abstract
Background
Stroke is a leading cause of disability and the fifth leading cause of death in the USA. Intravenous alteplase is a highly effective clot-dissolving stroke treatment that must be given in a hospital setting within a time-sensitive window. To increase the use of intravenous alteplase in stroke patients, many US counties enacted policies mandating emergency medical service (EMS) paramedics to bypass local emergency departments and instead directly transport patients to specially equipped stroke centers. The objective of this mixed-methods study is to evaluate the effectiveness of policy enactment as an implementation strategy, how differences in policy structures and processes impact effectiveness, and to explore how the county, hospital, and policy factors explain variation in implementation and clinical outcomes. This paper provides a detailed description of an Agency for Healthcare Quality and Research (AHRQ)-funded protocol, including the use of the Consolidated Framework for Implementation Research (CFIR) in the qualitative design.

Methods/design
We will construct the largest-ever national stroke database of Medicare enrollees (~ 1.5 million stroke patients) representing 896 policy counties paired with 1792 non-policy counties, then integrate patient-, hospital-, county-, and state-level covariates from eight different data sources. We will use a difference-in-differences analysis to estimate the overall effect of the policy enactment on intravenous alteplase use (implementation outcome) as well as key patient outcomes. We will also quantitatively examine if variation in the context (urban/rural status) and variation in policy features affect outcomes. Finally, a CFIR-informed multiple case study design will be used to interview informants in 72 stakeholders in 24 counties to identify and validate factors that enable policy effects.

Discussion
Policies can be potent implementation strategies. However, the effects of EMS bypass policies to increase intravenous alteplase use have not been rigorously evaluated. By learning how context and policy structures impact alteplase implementation, as well as the barriers and facilitators experienced by stakeholders responsible for policy enactment, the results of this study will inform decisions regarding if and how EMS bypass policies should spread to non-policy counties, and if indicated, creation of a “best practices” toolkit.
Inflammation as a treatment target in mood disorders: review
Authors: Jones Brett D. M. , Daskalakis Zafiris J. , Carvalho Andre F. , Strawbridge Rebecca , Young Allan H. , Mulsant Benoit H. , Husain M. Ishrat 
Published: June 2020

Background
Mood disorders, i.e. major depressive disorder (MDD) and bipolar disorders, are leading sources of disability worldwide. Currently available treatments do not yield remission in approximately a third of patients with a mood disorder. This is in part because these treatments do not target a specific core pathology underlying these heterogeneous disorders. In recent years, abnormal inflammatory processes have been identified as putative pathophysiological mechanisms and treatment targets in mood disorders, particularly among individuals with treatment-resistant conditions.

Aims
In this selective review, we aimed to summarise recent advances in the field of immunopsychiatry, including emerging pathophysiological models and findings from treatment ttrials of immunomodulatory agents for both MDD and bipolar disorders.

Method
We performed a literature review by searching Medline for clinical trials of immunomodulating agents as monotherapy or adjunctive treatments in MDD and bipolar disorders. Included studies are randomised controlled trials (RCTs), cluster RCTs or cross-over trials of immunomodulating agents that had an active comparator or a placebo-arm.

Results
Current evidence shows an association between inflammation and mood symptoms. However, there is conflicting evidence on whether this link is causal.

Conclusions
Future studies should focus on identifying specific neurobiological underpinnings for the putative causal association between an activated inflammatory response and mood disorders. Results of these studies are needed before further treatment trials of immunomodulatory agents can be justified.
Hydroxyethyl Starch 6% 130/0.4 in a Balanced Electrolyte Solution and Renal Function After Nephrectomy
Authors: Lee Ho-Jin , Kwon Yongsuk , Bae Jinyoung , Yoo Seokha , Yoon Hee-Chul , Yoon Soo-Hyuk , Kim Jin-Tae , Bahk Jae-Hyon , Kim Won Ho 
Published: June 2020

BACKGROUND:
Although previous studies have reported nephrotoxicity associated with hydroxyethyl starch (HES), the long-term effect of HES on renal function after nephrectomy has rarely been reported. We evaluated the association between intraoperative HES administration and short- and long-term renal function after nephrectomy.

METHODS:
We retrospectively reviewed 1106 patients who underwent partial or radical nephrectomy. The patients were divided into 2 groups: patients who received (HES group) or did not receive 6% HES 130/0.4 intraoperatively (non-HES group). The primary outcome was new-onset chronic kidney disease (CKD) stage 3a (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2) or higher or all-cause mortality during 60 months after surgery. Propensity score matching was performed to address baseline differences between the 2 groups. Renal survival determined by stage 3a and stage 5 CKD (eGFR <15 mL/min/1.73 m2) or all-cause mortality were compared up to 60 months before and after matching. We compared postoperative acute kidney injury (AKI) and CKD upstaging in the matched cohort as secondary outcomes. Ordinal logistic regression and Cox proportional hazards regression analyses using inverse probability of treatment weighting were performed for postoperative AKI and our primary outcome, respectively. A subgroup analysis of partial nephrectomy was performed.

RESULTS:
Thirty percent of patients received HES intraoperatively. Balanced solution and 0.9% normal saline was administered during surgery in both groups. Renal survival was not significantly different between groups after matching (log-rank test P = .377 for our primary outcome, and P = .981 for stage 5 or all-cause mortality, respectively). In the matched cohort (HES group: n = 280, non-HES group: n = 280), the incidence of AKI or CKD upstaging at 1 year was not significantly different (AKI: n = 94, 33.6% in HES group versus n = 90, 32.1% in non-HES group; CKD upstaging: n = 132, 47.1% in HES group versus n = 122, 43.6% in non-HES group; odds ratio [OR], 1.16; 95% confidence interval [CI], 0.83–1.61; P = .396). Intraoperative HES administration was not associated with postoperative renal outcomes (AKI: OR, 0.97; 95% CI, 0.81–1.16; P = .723; CKD stage 3a or higher or all-cause mortality: hazard ratio, 1.01; 95% CI, 0.89–1.14; P = .920). Subgroup analysis yielded similar results.

CONCLUSIONS:
Intraoperative 6% HES 130/0.4 administration was not significantly associated with short- and long-term renal function or renal survival up to 5 years in patients undergoing partial or radical nephrectomy. However, wide CI including large harm effect precludes firm conclusion and inadequate assessment of safety cannot be ruled out by our results.
Cone beam computed tomography in dentomaxillofacial radiology: a two-decade overview
Authors: Gaêta-Araujo Hugo , Alzoubi Tamara , Vasconcelos Karla de Faria , Orhan Kaan , Pauwels Ruben , Casselman Jan W , Jacobs Reinhilde 
Published: June 2020

Objectives: The aim of this study was to evaluate and summarise features of currently and formerly available cone beam CT (CBCT) devices from 1996 to 2019. Additionally, a recommendation for standardised reporting of CBCT characteristics was provided. Methods and materials: Information about the features of all available CBCT devices was obtained from the manufacturers’ available data. Moreover, site visits to newly developed CBCT machines’ manufacturers were performed in order to obtain relevant information. Results: A total of 279 CBCT models from 47 manufacturers located in 12 countries (Brazil, China, Denmark, Finland, France, Germany, Italy, Japan, Republic of Korea, Slovakia, Thailand, and USA) could be listed. Overall, wide variations in CBCT features and technical specifications were identified. Conclusions: CBCT in dentomaxillofacial radiology is a generic term applicable to a broad range of CBCT machines and features. Experimental outcomes and literature statements regarding radiation doses, imaging performance and diagnostic applicability of dental CBCT cannot be simply transferred from one CBCT model to another considering a wide variation in technical characteristics and clinical diagnostic performance. The information tabulated in the present study will be later provided on the International Association of DentoMaxilloFacial Radiology website ( www.iadmfr.one ).
Human umbilical cord blood-mesenchymal stem cell-derived secretome in combination with atorvastatin enhances endothelial progenitor cells proliferation and migration
Authors: Oktaviono Yudi Her , Hutomo Suryo Ardi , Al-Farabi Makhyan Jibril , Chouw Angliana , Sandra Ferry 
Published: June 2020

Background: Human umbilical cord blood-mesenchymal stem cell (hUCB-MSC)-derived secretome is known to be able to promote neovascularization and angiogenesis, so it is also thought to have a capability to modulate endothelial progenitor cell (EPC) functions. Atorvastatin is the cornerstone of coronary artery disease (CAD) treatment which can enhance EPCs proliferation and migration. This study aims to analyze the effect of the hUCB-MSC-derived secretome and its combination with atorvastatin toward EPCs proliferation and migration. Methods: EPCs were isolated from a CAD patient’s peripheral blood. Cultured EPCs were divided into a control group and treatment group of 2.5 µM atorvastatin, hUCB-MSC-derived secretome (2%, 10%, and 20% concentration) and its combination. EPCs proliferation was evaluated using an MTT cell proliferation assay, and EPC migration was evaluated using a Transwell migration assay kit. Results: This research showed that hUCB-MSC-derived secretomes significantly increase EPC proliferation and migration in a dose-dependent manner. The high concentration of hUCB-MSC-derived secretome were shown to be superior to atorvastatin in inducing EPC proliferation and migration (p<0.001). A combination of the hUCB-MSC-derived secretome and atorvastatin shown to improve EPCs proliferation and migration compared to hUCB-MSC-derived secretome treatment or atorvastatin alone (p<0.001). Conclusions: This study concluded that the hUCB-MSC-derived secretome work synergistically with atorvastatin treatment in improving EPCs proliferation and migration.
What settings have been linked to SARS-CoV-2 transmission clusters?
Authors: Leclerc Quentin J. , Fuller Naomi M. , Knight Lisa E. ,   CMMID COVID-19 Working Group, Funk Sebastian , Knight Gwenan M. 
Published: June 2020

Background: Concern about the health impact of novel coronavirus SARS-CoV-2 has resulted in widespread enforced reductions in people’s movement (“lockdowns”). However, there are increasing concerns about the severe economic and wider societal consequences of these measures. Some countries have begun to lift some of the rules on physical distancing in a stepwise manner, with differences in what these “exit strategies” entail and their timeframes. The aim of this work was to inform such exit strategies by exploring the types of indoor and outdoor settings where transmission of SARS-CoV-2 has been reported to occur and result in clusters of cases. Identifying potential settings that result in transmission clusters allows these to be kept under close surveillance and/or to remain closed as part of strategies that aim to avoid a resurgence in transmission following the lifting of lockdown measures. Methods: We performed a systematic review of available literature and media reports to find settings reported in peer reviewed articles and media with these characteristics. These sources are curated and made available in an editable online database. Results: We found many examples of SARS-CoV-2 clusters linked to a wide range of mostly indoor settings. Few reports came from schools, many from households, and an increasing number were reported in hospitals and elderly care settings across Europe. Conclusions: We identified possible places that are linked to clusters of COVID-19 cases and could be closely monitored and/or remain closed in the first instance following the progressive removal of lockdown restrictions. However, in part due to the limits in surveillance capacities in many settings, the gathering of information such as cluster sizes and attack rates is limited in several ways: inherent recall bias, biased media reporting and missing data.
Role of the probe beam in a radio-frequency atomic magnetometer
Authors: Bevington Patrick , Rajroop Jenelle , Gartman Rafal , Chalupczak Witold 
Published: June 2020

We explore the role of the linearly polarized probe beam in the radio-frequency atomic magnetometer. Two regimes of coupling of the linearly polarized light to the atomic ensemble, near and off-resonant, are demonstrated and discussed. Our studies cover three types of interaction between the atomic spin system and the linearly polarized beam, i.e., absorptive production of spin polarization, dispersive spin state readout, and nonlinear spin couplings. The work is performed with the outlook of optimization and simplification of magnetometer operation. Operation of a magnetometer with a single beam, generating and probing the atomic orientation, is presented. This single-beam configuration, which combines optical pumping, nonlinear spin couplings, and spin-exchange collisions, creates the option for a portable device with simple instrumentation.
Importância do diagnóstico laboratorial para a sífilis congênita no pré-natal
Authors: De Arruda Leandro Ricardo , Dos Santos Ramos Aleksandra Rosendo 
Published: June 2020

Este estudo foi proposto com o objetivo de analisar a partir de uma revisão da literatura nacional, a importância do diagnóstico laboratorial para a sífilis congênita no pré-natal no Brasil no período de 2002 a 2016. Buscando identificar como anda a relação de sífilis congênita, sua epidemiologia, as medidas tomadas no pré-natal e seu diagnóstico laboratorial, descrevendo os efeitos nocivos da sífilis congênita na sociedade brasileira. Realizou-se um estudo utilizando-se a pesquisa bibliográfica quantitativa que auxilie a defesa da realização do diagnóstico da sífilis congênita no pré-natal. Realizando revisão da literatura nacional em bancos de dados, sendo selecionados artigos publicados nos últimos anos, abordando a sífilis congênita dentre outras coisas. A sífilis congênita é o resultado da disseminação hematogênica do Treponema pallidum, da gestante infectada não tratada ou inadequadamente tratada para o seu concepto, por via transplacentária. As considerações finais desse estudo é que a sífilis congênita é um problema de saúde nacional, ainda hoje pouco controlado, sendo necessário o acesso dos meios de prevenção, controle, informação e diagnósticos laboratoriais no pré-natal disponível e efetivamente pleno para a saúde das gestantes.