bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Fornax 4 the nuclear star cluster of the Fornax dwarf spheroidal galaxy?
Authors: Martocchia S , Dalessandro E , Salaris M , Larsen S , Rejkuba M 
Published: June 2020

ABSTRACT
Fornax 4 is the most distinctive globular cluster in the Fornax dwarf spheroidal. Located close to the centre of the galaxy, more metal-rich and potentially younger than its four companions (namely, Fornax clusters number 1, 2, 3, and 5), it has been suggested to have experienced a different formation than the other clusters in the galaxy. Here, we use Hubble Space Telescope/WFC3 photometry to characterize the stellar population content of this system and shed new light on its nature. By means of a detailed comparison of synthetic horizontal branch and red giant branch with the observed colour–magnitude diagrams, we find that this system likely hosts stellar sub-populations characterized by a significant iron spread up to Δ[Fe/H] ∼ 0.4 dex and possibly by also some degree of He abundance variations ΔY ∼ 0.03. We argue that this purely observational evidence, combined with the other peculiarities characterizing this system, supports the possibility that Fornax 4 is the nuclear star cluster of the Fornax dwarf spheroidal galaxy. A spectroscopic follow-up for a large number of resolved member stars is needed to confirm this interesting result and to study in detail the formation and early evolution of this system and more in general the process of galaxy nucleation.
What determines the maximum stellar surface density of galaxies?
Authors: Ling Chih-Teng , Hashimoto Tetsuya , Goto Tomotsugu , Lu Ting-Yi , On Alvina Y L , Santos Daryl Joe D , Hsiao Tiger Y-Y , Ho Simon C-C 
Published: June 2020

ABSTRACT
Observationally, it has been reported that the densest stellar system in the Universe does not exceed a maximum stellar surface density, $\Sigma ^{\max }_{*}$ = $3\times 10^5\, {\rm M}_{\odot }\,{\rm pc}^{-2}$, throughout a wide physical scale ranging from star cluster to galaxy. This suggests that there exists a fundamental physics that regulates the star formation and stellar density. However, factors that determine this maximum limit are not clear. In this study, we show that $\Sigma ^{\max }_{*}$ of galaxies is not a constant as previous work reported, but actually it depends on the stellar mass. We select galaxy sample from the Sloan Digital Sky Survey Data Release 12 at z = 0.01–0.5. In contrast to a constant maximum predicted by theoretical models, $\Sigma ^{\max }_{*}$ strongly depends on stellar mass, especially for less massive galaxies with $\text{$\sim$}10^{10}\, {\rm M}_{\odot }$. We also found that a majority of high-Σ* galaxies show red colours and low star formation rates. These galaxies probably reach the $\Sigma ^{\max }_{*}$ as a consequence of the galaxy evolution from blue star forming to red quiescent by quenching star formation. One possible explanation of the stellar-mass dependence of $\Sigma ^{\max }_{*}$ is a mass-dependent efficiency of stellar feedback. The stellar feedback could be relatively more efficient in a shallower gravitational potential, which terminates star formation quickly before the stellar system reaches a high stellar density.
Testing the cosmic curvature at high redshifts: the combination of LSST strong lensing systems and quasars as new standard candles
Authors: Liu Tonghua , Cao Shuo , Zhang Jia , Biesiada Marek , Liu Yuting , Lian Yujie 
Published: June 2020

ABSTRACT
The cosmic curvature, a fundamental parameter for cosmology could hold deep clues to inflation and cosmic origins. We propose an improved model-independent method to constrain the cosmic curvature by combining the constructed Hubble diagram of high-redshift quasars with galactic-scale strong lensing systems expected to be seen by the forthcoming Large Synoptic Survey Telescope survey. More specifically, the most recent quasar data are used as a new type of standard candles in the range 0.036 &lt; z &lt; 5.100, whose luminosity distances can be directly derived from the non-linear relation between X-ray and UV luminosities. Compared with other methods, the proposed one involving the quasar data achieves constraints with higher precision (ΔΩk ∼ 10−2) at high redshifts (z ∼ 5.0). We also investigate the influence of lens mass distribution in the framework of three types of lens models extensively used in strong lensing studies (SIS model, power-law spherical model, and extended power-law lens model), finding the strong correlation between the cosmic curvature and the lens model parameters. When the power-law mass density profile is assumed, the most stringent constraint on the cosmic curvature Ωk can be obtained. Therefore, the issue of mass density profile in the early-type galaxies is still a critical one that needs to be investigated further.
Progenitors of early-time interacting supernovae
Authors: Boian Ioana , Groh Jose H 
Published: June 2020

ABSTRACT
We compute an extensive set of early-time spectra of supernovae interacting with circumstellar material using the radiative transfer code cmfgen. Our models are applicable to events observed from 1 to a few days after explosion. Using these models, we constrain the progenitor and explosion properties of a sample of 17 observed interacting supernovae at early times. Because massive stars have strong mass-loss, these spectra provide valuable information about supernova progenitors, such as mass-loss rates, wind velocities, and surface abundances. We show that these events span a wide range of explosion and progenitor properties, exhibiting supernova luminosities in the 108 to 1012 L⊙ range, temperatures from 10 000 to 60 000 K, progenitor mass-loss rates from a few 10−4 up to 1 M⊙ yr−1, wind velocities from 100 to 800 km s−1, and surface abundances from solar-like to H-depleted. Our results suggest that many progenitors of supernovae interacting with circumstellar material have significantly increased mass-loss before explosion compared to what massive stars show during the rest of their lifetimes. We also infer a lack of correlation between surface abundances and mass-loss rates. This may point to the pre-explosion mass-loss mechanism being independent of stellar mass. We find that the majority of these events have CNO-processed surface abundances. In the single star scenario this points to a preference towards high-mass RSGs as progenitors of interacting SNe, while binary evolution could impact this conclusion. Our models are publicly available and readily applicable to analyse results from ongoing and future large-scale surveys such as the Zwicky Transient Factory.
Inertial oscillation modes of an inclined dipolar magnetosphere as a source of band-limited noise in X-ray pulsars
Authors: Abolmasov Pavel , Biryukov Anton 
Published: June 2020

ABSTRACT
Magnetic fields of strongly magnetized stars can trap conducting matter due to frozen-in condition. In the force-free regime, the motion of the matter along the field lines may be considered in the ‘bead on a wire’ approximation. Such a motion, if gravity and centrifugal forces are taken into account, has equilibrium points, some of which are stable. In most cases, stability is possible in about several per cent of the possible locations. Corresponding oscillation frequencies span the range from zero to $\sqrt{3}$ of the spin frequency. We suggest that this variability mode may be excited in some X-ray pulsars during the outbursts and create the peaked broad-band noise component near the break frequency in the power density spectrum, as well as produce some of the quasi-periodic oscillation features in this frequency range. Existence of this variability does not require any changes in mass accretion rate and involves only a small amount of matter infiltrating from the disc and magnetic flow due to interchange instabilities.
Human chorionic gonadotropin improves endometrial receptivity by increasing the expression of homeobox A10
Authors: Zhu Mengchen , Yi Shanling , Huang Xiaomin , Meng Junan , Sun Haixiang , Zhou Jianjun 
Published: June 2020

Abstract
Homeobox A10 (HOXA10) is a characterized marker of endometrial receptivity. The mechanism by which hCG intrauterine infusion promotes embryo implantation is still unclear. This study seeks to investigate whether hCG improves endometrial receptivity by increasing expression of HOXA10. HOXA10 expression with human chorionic gonadotropin stimulation was analyzed in vitro and in vivo. Our results demonstrate that HOXA10 was decreased in the endometria of recurrent implantation failure patients compared to that in the healthy control fertile group, also we observed that hCG intrauterine infusion increased endometrial HOXA10 expression. HOXA10, blastocyst-like spheroid expansion area was increased, whereas DNA (cytosine-5-)-methyltransferase 1 was decreased when human endometrial stromal cells (hESCs) were treated with 0.2 IU/ml of hCG for 48 h. HOXA10 promoter methylation was also reduced after hCG treatment. Collagen XV (ColXV) can repress the expression of DNA (cytosine-5-)-methyltransferase 1, and hCG treatment increased the expression of ColXV. However, when the hESCs were treated with LH/hCG receptor small interfering RNA to knock down LH/hCG receptor, hCG treatment failed to repress DNA (cytosine-5-)-methyltransferase 1 expression or to increase ColXV expression. Our findings suggest that hCG may promote embryo implantation by increasing the expression of HOXA10.
Perspectives of Patients on Outpatient Parenteral Antimicrobial Therapy: Experiences and Adherence
Authors: Hamad Yasir , Dodda Sai , Frank Allison , Beggs Joe , Sleckman Christopher , Kleinschmidt Glen , Lane Michael A , Burnett Yvonne 
Published: June 2020

Abstract

Background
Nonadherence to medication is a burden to the US health care system and is associated with poor clinical outcomes. Data on outpatient parenteral antimicrobial therapy (OPAT) treatment plan adherence are lacking. The purpose of this study is to determine the rate of nonadherence and factors associated with it.

Methods
We surveyed patients discharged from a tertiary hospital on OPAT between February and August 2019 about their baseline characteristics, OPAT regimen, adherence, and experience with OPAT.

Results
Sixty-five patients responded to the survey. The median age was 62 years, and 56% were male. The rate of reported nonadherence to intravenous (IV) antibiotics was 10%. Factors associated with nonadherence to IV antibiotics included younger age, household income of &lt;$20 000, and lack of time for administering IV antibiotics (30 vs 64 years, P &lt; .01; 83% vs 20%, P &lt; .01, and 33% vs 4%, P = .04, in the nonadherent vs adherent groups, respectively), while less frequent administration (once or twice daily) and having friend or family support during IV antibiotic administration were associated with better adherence (17% vs 76%, P &lt; .01, and 17% vs 66%, P = .03, in the nonadherent vs adherent groups, respectively). Most patients attended their infectious diseases clinic visits (n = 44, 71%), and the most commonly cited reasons for missing an appointment were lacking transportation (n = 12, 60%), not feeling well (n = 8, 40%), and being unaware of the appointment (n = 6, 30%).

Conclusions
Less frequent antibiotic dosing and better social support were associated with improved adherence to OPAT. In contrast, younger age, lower income, and lack of time were associated with nonadherence.
Corticosteroid discontinuation, complete clinical response and remission in juvenile dermatomyositis
Authors: Kishi Takayuki , Warren-Hicks William , Bayat Nastaran , Targoff Ira N , Huber Adam M , Ward Michael M , Rider Lisa G ,   with the Childhood Myositis Heterogeneity Study Group
Published: June 2020

AbstractObjectiveA North American registry of JDM patients was examined for frequency of and factors associated with corticosteroid discontinuation, complete clinical response and remission.MethodsWe evaluated probability of achieving final corticosteroid discontinuation, complete clinical response and remission in 307 JDM patients by Weibull time-to-event modelling; conditional probability of complete clinical response and remission using Bayesian network modelling; and significant predictors with multivariable Markov chain Monte-Carlo Weibull extension models.ResultsThe probability of corticosteroid discontinuation was 56%, complete clinical response 38% and remission 30% by 60 months after initial treatment in 105 patients. The probability of remission was conditional on corticosteroid discontinuation and complete clinical response. Photosensitivity, contractures and a longer time to complete clinical response were predictive of the time to final corticosteroid discontinuation. Anti-MJ (NXP2) autoantibodies and a Northwest residential geoclimatic zone were predictive of shorter time to complete clinical response, while dysphonia, contractures, an increase in medications within 24 months and a longer time to corticosteroid discontinuation were associated with longer time to complete clinical response. Anti-p155/140 (TIF1) autoantibodies, an increase in medications within 12–24 months, or longer times to corticosteroid discontinuation and complete clinical response were associated with longer time to remission.ConclusionJDM patients achieve favourable outcomes, including corticosteroid discontinuation, complete clinical response and remission, although timelines for these may be several years based on time-dependent analyses. These outcomes are inter-related and strong predictors of each other. Selected clinical features and myositis autoantibodies are additionally associated with these outcomes.
A White Matter Connection of Schizophrenia and Alzheimer’s Disease
Authors: Kochunov Peter , Zavaliangos-Petropulu Artemis , Jahanshad Neda , Thompson Paul M , Ryan Meghann C , Chiappelli Joshua , Chen Shuo , Du Xiaoming , Hatch Kathryn , Adhikari Bhim , Sampath Hemalatha , Hare Stephanie , Kvarta Mark , Goldwaser Eric , Yang Fude , Olvera Rene L , Fox Peter T , Curran Joanne E , Blangero John , Glahn David C , Tan Yunlong , Hong L Elliot 
Published: June 2020

Abstract
Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features. We hypothesized that aging in SZ patients may be associated with the development of cerebral white matter deficit patterns similar to those observed in AD. We identified and replicated aging-related increases in the similarity between white matter deficit patterns in patients with SZ and AD. The white matter “regional vulnerability index” (RVI) for AD was significantly higher in SZ patients compared with healthy controls in both the independent discovery (Cohen’s d = 0.44, P = 1·10–5, N = 173 patients/230 control) and replication (Cohen’s d = 0.78, P = 9·10–7, N = 122 patients/64 controls) samples. The degree of overlap with the AD deficit pattern was significantly correlated with age in patients (r = .21 and .29, P &lt; .01 in discovery and replication cohorts, respectively) but not in controls. Elevated RVI-AD was significantly associated with cognitive measures in both SZ and AD. Disease and cognitive specificities were also tested in patients with mild cognitive impairment and showed intermediate overlap. SZ and AD have diverse etiologies and clinical courses; our findings suggest that white matter deficits may represent a key intersecting point for these 2 otherwise distinct diseases. Identifying mechanisms underlying this white matter deficit pattern may yield preventative and treatment targets for cognitive deficits in both SZ and AD patients.
Explaining the exceptional 4270 m high elevation limit of an evergreen oak in the south-eastern Himalayas
Authors: Yang Yang , Sun Hang , Körner Christian 
Published: June 2020

Abstract
Unlike the well-understood alpine treeline, the upper range limits of tree taxa that do not reach the alpine treeline are largely unexplained. In this study, we explored the causes of the exceptionally high elevation (4270 m) occurrence of broad-leaved evergreen oaks (Quercus pannosa) in the south-eastern Himalayas. We assessed the course of freezing resistance of buds and leaves from winter to summer at the upper elevational limit of this oak species. Linked to leaf phenology, we analyzed freezing resistance and assessed minimum crown temperature for the past 65 years. We also examined potential carbon limitation at the range limit of this species. Last season buds and leaves operated at a safety margin of 5.5 and 11 K in mid-winter. Once fully dehardened early in July, last season foliage is damaged at −5.9 and new foliage at −4.6 °C. Bud break is timed for late June to early July when low temperature extremes historically were never below −3.0 °C. The monsoon regime ensures a long remaining season (149 days), thus compensating for the late onset of shoot growth. Compared with a site at 3450 m, specific leaf area is reduced, foliar non-structural carbohydrate concentrations are similar and the δ13C signal is higher, jointly suggesting that carbon limitation is unlikely at the range limit of this species. We also show that these oaks enter the growing season with fully intact (not embolized) xylem. We conclude that the interaction between phenology and freezing tolerance results in safe flushing, while still facilitating shoot maturation before winter. These factors jointly determine the upper range limit of this oak species. Our study illuminates an exceptional case of broad-leaved evergreen tree performance near the treeline, and by exploring a suite of traits, we can underpin the central role of flushing phenology in such a stressful environment.
Risk of Miscarriage Following Amniocentesis or Chorionic Villus Sampling: Systematic Review of Literature and Updated Meta-analysis
Authors: Salomon L. J. , Sotiriadis A. , Wulff C. B. , Odibo A. , Akolekar R. 
Published: June 2020

(Abstracted from Ultrasound Obstet Gynecol 2019;54:442–451)
Evidence suggests that the risk of miscarriage after invasive prenatal testing is much lower than that cited by professional bodies. Since the last reported systematic review of this risk in 2015, more large studies have been conducted, and advances in equipment and techniques have been made.
Race, Social Status, and Depressive Symptoms
Authors: Aroke Edwin N. , Jackson Pamela , Overstreet Demario S. , Penn Terence M. , Rumble Deanna D. , Kehrer Caroline V. , Michl Ava N. , Hasan Fariha N. , Sims Andrew M. , Quinn Tammie , Long D. Leann , Goodin Burel R. 
Published: June 2020

Background:
Chronic low back pain (cLBP) is the leading cause of disability, with a significant societal cost. It disproportionately affects non-Hispanic blacks and individuals of lower socioeconomic status. The biopsychosocial framework has been used to study and manage cLBP, yet disparities persist.

Objective:
The objective of this study was to assess whether self-identified race moderated the relationship between perceived social status and cLBP outcomes (pain interference and pain severity) and investigate whether race moderated the indirect relationship between perceived social status and pain outcomes via depressive symptoms.

Methods:
Fifty-seven blacks and 48 whites with cLBP were recruited as part of a large ongoing study. Depressive symptoms, objective and subjective measures of socioeconomic status, and pain outcomes were measured. Hayes’ moderated mediation model was used to estimate conditional direct and indirect relationship between these variables.

Result:
On average black participants reported significantly more pain interference (4.12 [SD=2.65] vs. 2.95 [SD=2.13]) and severity (5.57 [SD=2.27] vs. 3.99 [SD=1.99]) than white participants, (P<0.05). Race moderated the association between perceived social status and pain interference: higher social status decreases pain interference for white participants, but that trend was not observed in black participants. Moreover, race moderated association of perceived social status with depressive symptoms (P<0.001); which mediates the effects of perceived social status on pain outcomes.

Conclusion:
Higher perceived social status is associated with less severe depressive symptoms, which in turn is associated with less pain severity and less pain interference for whites but not for blacks with cLBP.
Impaired School Functioning in Children With Chronic Pain
Authors: Groenewald Cornelius B. , Tham See Wan , Palermo Tonya M. 
Published: June 2020

Objective:
The purpose of this study was to determine the association between presence of chronic pain and school functioning among school-aged children (6 to 17 y) using the most recent United States national data.

Materials and Methods:
Secondary data analyses of the 2016-2017 National Survey of Children’s Health. Parents (n=48,254) reported on whether their child had chronic pain over the past 12 months. Parents also reported on school functioning including (1) engagement with school, (2) number of school days missed, (3) problems at school, (4) repeating a grade, and (5) diagnosis of a learning disability. Children with chronic pain were compared with children without chronic pain using multivariate logistic regression models. We also stratified analysis according to age and sex.

Results:
In multivariate analyses, children with pain were more likely to have low school engagement (adjusted odds ratio [OR]: 1.4, 95% confidence interval [CI]: 1.0-1.9), be chronically absent (OR: 4.2, 95% CI: 3.0-5.8), have school-related problems (OR: 1.9, 95% CI: 1.5-2.3), repeat a grade (OR: 1.4, 95% CI: 1.0-2.0), and be diagnosed with a learning disability (OR: 1.6, 95% CI: 1.1-2.5). In stratified analyses, associations between chronic pain and school measures were strongest among adolescents (15 to 17 y of age) and males.

Discussion:
This study extends evidence linking chronic pain status to poorer school functioning in a large, national sample. Poor school functioning is a pressing public concern affecting children with chronic pain. Health care providers, educators, policymakers, and families should work together to ensure that needs are met for this vulnerable population.
Syndemic theory, structural violence and HIV among African–Americans
Authors: Godley Bria A. , Adimora Adaora A. 
Published: June 2020

Purpose of review
This paper will review recent use of syndemic frameworks in HIV research among African–Americans.

Recent findings
Researchers have used syndemic theory in diverse African–American study populations, including MSM, cis-women, trans-women, heterosexual men and adolescents. These studies have evaluated the associations between syndemic conditions and a variety of outcomes, such as sexual behaviours, HIV and other sexually transmitted infections, HIV testing, adherence to antiretroviral therapy, HIV suppression and preexposure prophylaxis use. The most frequently evaluated syndemic conditions have been depression, substance use and personal experience of abuse or violence; a few studies have included experience of incarceration and unstable housing.

Summary
These studies have yielded valuable insights into links between HIV-related outcomes and mental health, experience of violence and abuse, and substance use. But a key feature – and major utility – of the syndemics framework is its potential for examining not only synergistic individual-level risk factors but also the interactions with economic, political and social systems that influence these individual-level factors and thereby shape the HIV epidemic among African–Americans. Research that takes these systems into account is needed to inform policy changes that can help end the HIV epidemic in this population.