bluuebunny/crossref_metadata_2025_split huggingface dataset:
A summary of high quality online information resources for parents with cancer who have adolescent and young adult children: A scoping review
Authors: Weeks Nicole , McDonald Fiona E.J. , Patterson Pandora , Konings Stephanie , Coad Jane 
Published: November 2019

AbstractObjectiveParents with cancer want information about maintaining family functioning despite cancer. This scoping review assesses what online information resources are available to help parents with cancer maintain family functioning, the quality of the available information, and whether resources provide specific advice for parents of adolescent and young adult (AYA) children.MethodsTo identify available relevant English‐language online information resources, we imitated a parental online information search using three search engines (Google, Yahoo, and Bing). Online resources from the last 10 years for parents with cancer addressing family functioning were included. These resources were rated using the DISCERN instrument—a tool for rating the reliability and quality of health information resources.Results684 results were screened and 33 online information resources from the USA, UK, Australia, Canada, and Ireland met the inclusion criteria. Average DISCERN quality was 54/80 (95% CI:50‐58), which is typical for online health information. The highest rated resources provided information for parents on supporting their AYA children's needs for information and support with feelings, but few comprehensively covered other specific AYA needs. Details on resource weaknesses as identified by the DISCERN are presented.ConclusionsSeveral high‐quality resources for parents with cancer were identified from multiple countries, allowing health professionals internationally to direct patients with cancer to relevant high quality online information. Highlighted limitations in resource quality and scope will guide future resource development and revision, ensuring more comprehensive high quality information is available to support families affected by parental cancer internationally.
Current surface issues in additive manufacturing
Authors: Magnien Julien , Cosemans Patrick , Nutal Nicolas , Kairet Thomas 
Published: November 2019

AbstractAdditive manufacturing (AM), the 30‐year‐old method, to make parts by stacking thin layers of a raw material‐like powder is still in evolution. Among the drawbacks of AM, surface quality is often reported, especially when the raw material is powder. The roughness, Ra, can vary between 10 and 20 µm, with a peak‐to‐valley distance which can reach 0.2 mm, depending on the AM technology. This has an impact on mechanical properties, especially on fatigue. One of the approaches to attain the surface requirements is dedicated post‐treatment. The present paper investigates the origin of AM roughness to highlight the need for suitable post‐treatment.
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression
Authors: Zhu Lihui , Jia Ruzhen , Zhang Junyong , Li Xiao , Qin Chengyong , Zhao Qi 
Published: November 2019

PurposeThe molecular pathogenesis of gastric cancer is still ambiguous till now. Here, it is demonstrated that long noncoding RNA (lncRNA) Ftx acts as a novel tumor promotor of gastric cancer and a potent regulator of hexokinase‐2 (HK2).Experimental designThe role of lncRNA Ftx is detected in the loss and gain‐of‐function models of gastric cancer cells. Tandem mass tags combined with multidimensional LC and MS analyses are performed to decipher comparative proteomic profiles of gastric cancer cells in response to lncRNA Ftx knockdown and overexpression. Real‐time roteomics‐clinical applications (PCR) and western blot are used to validate the proteomic data.ResultsA total of 5124 proteins are quantified and indicated in diverse biological functions and metabolic related signaling pathways. Interestingly, HK2, which is downregulated when lncRNA Ftx is deleted and upregulated while lncRNA Ftx is overexpressed, is further validated in gastric cancer cells.Conclusions and clinical relevanceThe present study suggests lncRNA Ftx promotes gastric cancer progression by upregulating HK2, which provides a new perspective for the mechanism of gastric cancer progression, and thus identifies potential therapeutic targets for gastric cancer.
The Dundee Resource for Sequence Analysis and Structure Prediction
Authors: MacGowan Stuart A. , Madeira Fábio , Britto‐Borges Thiago , Warowny Mateusz , Drozdetskiy Alexey , Procter James B. , Barton Geoffrey J. 
Published: November 2019

AbstractThe Dundee Resource for Sequence Analysis and Structure Prediction (DRSASP; http://www.compbio.dundee.ac.uk/drsasp.html) is a collection of web services provided by the Barton Group at the University of Dundee. DRSASP's flagship services are the JPred4 webserver for secondary structure and solvent accessibility prediction and the JABAWS 2.2 webserver for multiple sequence alignment, disorder prediction, amino acid conservation calculations, and specificity‐determining site prediction. DRSASP resources are available through conventional web interfaces and APIs but are also integrated into the Jalview sequence analysis workbench, which enables the composition of multitool interactive workflows. Other existing Barton Group tools are being brought under the banner of DRSASP, including NoD (Nucleolar localization sequence detector) and 14‐3‐3‐Pred. New resources are being developed that enable the analysis of population genetic data in evolutionary and 3D structural contexts. Existing resources are actively developed to exploit new technologies and maintain parity with evolving web standards. DRSASP provides substantial computational resources for public use, and since 2016 DRSASP services have completed over 1.5 million jobs.
Re‐emigration of foreign‐born residents from Sweden: 1990–2015
Authors: Monti Andrea 
Published: November 2019

AbstractThis paper is an analysis of patterns and determinants of return and onward migration among foreign‐born individuals residing in Sweden from 1990 to 2015. Who is emigrating, and where do they go? What are the determinants of return and onward migration? Increased diversity in international migration flows includes an increase in repeat migration. However, studies of re‐emigration have often failed to appropriately distinguish emigration types and have traditionally been limited to economic analysis of labour migrants. Using high‐quality register data from Sweden, this paper analyses re‐emigration through the conditions upon first immigration and evolving social and economic integration in the host country. Although return migration is found to be the main form of remigration type, onward migration is more prominent among specific migrant groups such as forced migrants. Additionally, various determinants of return and onward migration stress the importance of treating them as distinct phenomena within the migration literature.
Formation of Hierarchical Architectures with Dimensional and Morphological Control in the Self‐Assembly of Conjugated Block Copolymers
Authors: Wang Meijing , Han Liang , Zhu Yulin , Qi Rui , Tian Leilei , He Feng 
Published: November 2019

AbstractPrecise control of dimensionality and morphology is a crucial requirement for realizing complex and hierarchical assembled structures, which has mainly been studied in highly crystalline systems. However, such results have rarely been reported in the self‐assembly of conjugated block copolymers with relatively weak π–π interactions. Herein, the realization of unique scarf‐like self‐assembled architectures based on the conjugated block copolymers through a facile one‐step approach is reported. Dimensional and morphological control of the micelles are realized by adjusting the block ratio and the solvent polarity. Then the transformation from 1D nanorods to the final hierarchical scarf micelles is observed. Furthermore, the underlying growth mechanism is mainly attributed to the driving force of intermolecular π–π interactions between conjugated core blocks. This work provides a highly effective strategy to prepare hierarchical architectures circumventing those multistep methods used in traditional crystallization system, which could expand the morphological diversity of self‐assembly and further facilitate the exploration of its functional applications.
Cobalt‐Encapsulated Nitrogen‐Doped Carbon Nanotube Arrays for Flexible Zinc–Air Batteries
Authors: Liu Lina , Wang Yue , Yan Feng , Zhu Chunling , Geng Bo , Chen Yujin , Chou Shu‐lei 
Published: November 2019

AbstractWith the current rapid growth of commercial applications for flexible and wearable optoelectronic devices, flexible power sources are very much in demand. Herein, a facile strategy to grow cobalt nanoparticles encapsulated in nitrogen‐doped carbon nanotube arrays on flexible carbon fiber cloth as self‐supported electrodes for high‐performance flexible zinc–air batteries is developed. Benefiting from high electrical conductivity and multiple active sites as well as free polymer binder, the self‐supported electrode exhibits excellent electrocatalytic activity. The maximum power density of a zinc–air battery using the self‐supported electrode as air cathode is higher than that of the zinc–air battery with Pt/C+IrO2 as air electrode. Furthermore, the zinc–air battery can be stably operated under external stress without obvious loss of the electrochemical performance. This work opens up a new pathway for the rational design of flexible electrodes for high‐performance flexible power sources.
Application of Microfluidics in Wearable Devices
Authors: Chen Guo , Zheng Jiangen , Liu Liyu , Xu Lei 
Published: November 2019

AbstractWearable devices integrated with various electronic modules, biological sensors, and chemical sensors have drawn large public attention. Due to their inherent advantages of superior stretchability, elaborate microstructure, high integration of multiple functions, and low cost, microfluidics are an excellent candidate and have already been widely used in wearable devices. Well‐designed microfluidic devices can realize excellent multiple functions in wearable devices, including sample collecting, handling and storage, sample analysis, signal converting and amplification, mechanic sensing, and power supplying. Moreover, the microfluidic wearable devices with further integration of wireless modules have exhibited potential applications in healthcare monitoring, clinical assessment, and human and intelligent device interaction. This review focuses on the latest advances on multifunctional wearable devices based on microfluidics, primarily including general functions and designs of microfluidic wearable devices, and their specific applications in physiological signal monitoring, clinical diagnosis and therapeutics, and healthcare.
The visualisation of focal liver lesions on ultrasound: A review of 300 liver ultrasounds with CT or MRI correlation
Authors: Ng Jian , Necas Martin , du Toit Tanya 
Published: November 2019

AbstractIntroductionConventional ultrasound (US) is the most common imaging investigation of the liver. The ability of US to visualise focal liver lesions (FLLs) can be limited by technical factors, patient characteristics, and operator experience. The aim of this study was to determine the percentage and types of FLLs that were visualised on conventional US when compared with CT or MRI.MethodologyThree hundred patients who received a US followed by CT or MRI within 10 days were retrospectively reviewed. The final outcome of all liver lesions was determined by the best available evidence.ResultsIn noncirrhotic livers, 168 FLLs were visualised ranging from 2 to 62 mm in size. The most common lesions were cysts (n = 107, 64%), indeterminate FLLs (n = 20, 12%), haemangiomas (n = 11, 7%), other benign FLLs (n = 10, 6%), and metastases (n = 9, 5%). US visualised 39 (23%) FLLs and failed to visualise 129 (77%). The visualisation of FLL increased with increasing lesion size. FLLs less than 10 mm were seldom visualised, whereas FLLs greater than 15 mm were visualised two‐thirds of the time. In cirrhotic livers, US failed to visualise malignant lesions in two patients. Disseminated metastatic liver disease was visualised on US in 94% of cases.ConclusionConventional US continues to play a major role in the screening for focal liver disease. US practitioners and clinicians should be aware that the ability of US to visualise FLLs is size dependent and may be limited in some patients.
The digital transformation of the public sphere
Authors: Santos Tiago , Louçã Jorge , Coelho Helder 
Published: November 2019

AbstractIn this paper, we study the relationship between social media and traditional media and their impact on democratic systems. We revisit the concepts of the public sphere and agenda‐setting and translate them into the current media landscape. Using topic‐modelling techniques, we then explore the effects of first level agenda‐setting in the Twitter debate on the Brexit referendum. Our results reveal a complex dynamic in the transmission of the media agenda to the public agenda. The traditional media dominated the debate, but not entirely, as alternative media played an important role in the campaign. The “Leave” campaign had more success in the transmission of its interpretative agenda, while the user‐generated content polarized the media's message. We conclude a list of recommendations to address the societal challenges posed by the transformation of the media environments.
Some Consequences of Socially Irresponsible, un‐systemic Behavior in Ports: A Case
Authors: Dragan Dejan , Mulej Matjaž 
Published: November 2019

AbstractHumankind requires social responsibility (SR) via its global bodies United Nations (in UN Global Compact) and International Standards Organization (in ISO 26000), for humankind to avoid global crises and extinction caused by Social irresponsibility (SI), resulting from un‐systemic behavior, i.e., over‐specialization and poor holism that interdisciplinary creative cooperation should replace, which pioneers of Systems Theory (Bertalanffy) and Cybernetics (Wiener) required and practiced several decades ago. Ports, providing logistic services, present potential SR or SI. The now‐a‐days technology causes more ports' SI than SR by waste, air, water, and land pollution. SI is nearly unavoidable, if process is not handled with systemic behavior (SB), including a (requisitely) holistic approach of any process participants. Authors present a stepwise regression statistical modeling research on a port, applying systems approach in a mathematical way, to study a chance of port's SB leading to SR rather than SI damaging local people. SR and SB are difficult to measure; they prevent problems and costs. SI causes measurable problems and costs to indirectly express (lacking) SR and SB.
Mechanical behavior of recycled coarse aggregates self‐compacting concrete‐filled steel tubular columns under eccentric compression
Authors: Yu Feng , Yin Longlong , Fang Yuan , Jiang Junjie 
Published: November 2019

AbstractThe mechanical behavior of recycled coarse aggregates self‐compacting concrete‐filled steel tubular columns (RCA ‐ SCCFST) under eccentric compression is investigated in this study. Nine specimens with different eccentricities (
e) and column length‐to‐diameter ratios (
L/D) are designed and tested, including six long columns (
L/D > 4) and three short columns (
L/D ≤ 4). Test results indicate that the long columns under eccentric compression exhibit overall flexural buckling failure, while the short columns under eccentric compression experience drum‐like bending failures. The ultimate bearing capacity of specimens decreases as eccentricity or column length‐to‐diameter ratio increases. The increase of column length‐to‐diameter ratio or eccentricity would accelerate the stiffness degradation. The ultimate longitudinal and circumference strains decrease as the eccentricity or column length‐to‐diameter ratio increases. The application of existing concrete filled steel tube (CFST) design specifications, such as American specification (AISC360‐16‐2016), Chinese code (GB50936‐2014) and Japanese code (AIJ‐1997) for the RCA ‐ SCCFST long columns are evaluated. AISC360‐16‐2016 and AIJ‐1997 are a little conservative. GB50936‐2014 is comparative accurate. Considering the influence of replacement ratio of RCA, a modified formula for predicting the ultimate bearing capacity of RCA ‐SCCFST long columns is presented in this study. The theoretical values estimated by the modified formula are in good agreement with test data.
Systems of systems: From mission definition to architecture description
Authors: Cherfa Imane , Belloir Nicolas , Sadou Salah , Fleurquin Régis , Bennouar Djamal 
Published: November 2019

AbstractSystems of Systems (SoS) encompass a group of distributed and independent systems. This class of systems requires recurrent adaptation at runtime owing to the uncertainty and variability of the runtime environment. Thus, during their execution, SoS can deviate from the initial specification, which is often a consequence of successive evolutions. This problem occurs mainly due to (a) weak communication between the SoS analysis stage and architecture stage and (b) the lack of links between the operational planning in the SoS analysis stage and systems that must be involved in the SoS architecture stage. This paper proposes a model‐based process that strengthens the links between the SoS analysis stage and the architecture stage in the wave life cycle. We ensure that the mission and role concepts for the SoS definition are sufficiently abstract to allow adaptation to the variability of the environment. This definition is translated into an abstract architecture that guides the choices of the system architect during the design and evolution stages. The proposed language is an adaptation of the Systems Modeling Language (SysML). Furthermore, we define a crowd management SoS to illustrate the process.
A novel VSG model suitable for the analyses of static/transient stability and rated power/energy capacity of energy storage system
Authors: Koiwa Kenta , Inoo Kouyou , Liu Kang‐Zhi , Zanma Tadanao 
Published: November 2019

AbstractThis paper proposes a novel model for the analysis and design of a virtual synchronous generator (VSGs). To enhance the stability in power systems with distributed generators, the concept of VSG has been proposed. The VSG is designed based on the swing equation of a synchronous generator ignoring the dynamics of current flowing through an interconnection reactor. However, responses obtained with actual system are different from those calculated from the model. It implies that the VSG cannot be correctly analyzed and designed by using the conventional model. This paper constructs an accurate VSG model considering the dynamics of current. Moreover, we address the stability analysis of the VSG and reveal a relation between the parameters of VSG controller and the rated power/energy capacity of energy storage systems equipped with the VSG based on the proposed model. © 2019 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Assessment of DNA damage and oxidative stress in juvenile Channa punctatus (Bloch) after exposure to multi‐walled carbon nanotubes
Authors: Ali Daoud , Falodah Fawaz A. , Almutairi Bader , Alkahtani Saad , Alarifi Saud 
Published: November 2019

AbstractMulti‐walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium‐battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have determined the toxic effects of MWCNTs on freshwater fish C. punctatus by assessing toxicological endpoints such as oxidative stress, mutagenicity, and genotoxicity after acute MWCNTs exposure for 5 days. MWCNTs LC50‐96 hours value for C. punctatus was 21.8 mg/L and on this basis three different MWCNTs concentrations were selected, that is, sub‐lethal I, II, and III, for 5‐days exposure trials with C. punctatus. The level of lipid peroxidation increased in the gills and kidney of exposed fish at sub‐lethal concentrations II and III. Contrastingly, glutathione decreased more in the gills than in the kidney. The activity of catalase enzymes decreased more in the gills than in the kidney at sublethal concentrations I and II. Glutathione S‐transferase decreased in gill tissue but increased in kidney tissue following sub‐lethal III exposure. Moreover, the level of glutathione reductase decreased in both tissues. In addition, MWCNTs genotoxicity was confirmed by DNA damage in lymphocytes, gills, kidney cells, and production of micronuclei (MNi) in red blood cells of freshwater fish following sub‐lethal I, II, and III exposures. In conclusion, this study revealed that application of micronucleus and comet assays for in vivo laboratory studies using freshwater fish for screening the genotoxic potential of MWCNTs.
First‐trimester screening for trisomies in pregnancies with vanishing twin
Authors: Chaveeva P. , Wright A. , Syngelaki A. , Konstantinidou L. , Wright D. , Nicolaides K. H. 
Published: November 2019

ABSTRACTObjectivesTo examine multiples of the median (MoM) values of serum free beta‐human chorionic gonadotropin (β‐hCG) and pregnancy‐associated plasma protein‐A (PAPP‐A) in a large series of pregnancies with a vanishing twin, determine the association of these values with the interval between embryonic death and blood sampling, and develop a model that would allow incorporation of these metabolites in first‐trimester combined screening for trisomy.MethodsThis was a retrospective study comparing maternal serum free β‐hCG and PAPP‐A levels at 11–13 weeks' gestation in 528 dichorionic pregnancies with a vanishing twin, including 194 (36.7%) with an empty gestational sac and 334 (63.3%) with a dead embryo, with those in 5280 normal singleton pregnancies matched for method of conception and date of examination. In vanishing‐twin pregnancies with a dead embryo, marker levels were examined in relation to the estimated time between embryonic death and maternal blood sampling.ResultsFirst, in pregnancies with a vanishing twin, median free β‐hCG MoM was not significantly different from that in normal singleton pregnancies (1.000; 95% CI, 0.985–1.016 vs 0.995; 95% CI, 0.948–1.044; P = 0.849). Second, PAPP‐A MoM was higher in vanishing‐twin pregnancies than in normal singleton pregnancies (1.000; 95% CI, 0.985–1.015), both in the group with an empty gestational sac (1.165; 95% CI, 1.080–1.256; P = 0.0001) and in that with a dead embryo (1.175; 95% CI, 1.105–1.249; P < 0.0001). Third, in vanishing‐twin pregnancies with a dead embryo, PAPP‐A MoM was related inversely to the interval between estimated gestational age at embryonic demise and blood sampling (P < 0.0001). Fourth, in first‐trimester screening for trisomy 21 in singleton pregnancies, the estimated detection rate, at a 5% false‐positive rate, was 82% in screening by a combination of maternal age and fetal nuchal translucency thickness, and this increased to 86% with the addition of serum free β‐hCG and to 91% with the addition of serum PAPP‐A. Fifth, similar performance of screening can be achieved in pregnancies with a vanishing twin, provided the appropriate adjustments are made to the level of PAPP‐A for the interval between estimated gestational age at embryonic demise and blood sampling.ConclusionsFirst‐trimester screening for trisomy in pregnancies with a vanishing twin should rely on a combination of maternal age, fetal nuchal translucency thickness and serum free β‐hCG, as in singleton pregnancy, without the use of serum PAPP‐A. Alternatively, PAPP‐A can be included but only after appropriate adjustment for the interval between estimated gestational age at fetal demise and blood sampling. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.