bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Right Ventricular Systolic Dysfunction on Outcome in Aortic Stenosis
Authors: Bohbot Yohann , Guignant Pierre , Rusinaru Dan , Kubala Maciej , Maréchaux Sylvestre , Tribouilloy Christophe 
Published: January 2020

Background:
Pulmonary hypertension is an established outcome predictor in patients with aortic stenosis (AS), but the prognostic impact of right ventricular dysfunction has not been well studied.

Methods:

We included 2181 patients (50.4% men; mean age, 77 years) with aortic valve area <1.3 cm
2
and analyzed the occurrence of all-cause death during follow-up according to tricuspid annular plane systolic excursion (TAPSE) quartiles.

Results:

Patients in the lowest quartile (TAPSE <17 mm) were at a high risk of death, whereas survival was comparable for the 3 other quartiles. Five-year survival was 55±2% for TAPSE <17 mm, 72±2% for TAPSE of 17 to 20 mm, 71±2% for TAPSE of 20 to 24 mm, and 73±2% for TAPSE >24 mm (overall
P
<0.001). TAPSE <17 mm was associated with increased mortality after adjustment for established prognostic factors (adjusted hazard ratio [HR], 1.55 [95% CI, 1.21–1.97]) and after further adjustment for aortic valve replacement (AVR; adjusted HR, 1.47 [95% CI, 1.15–1.87]). The excess mortality risk associated with TAPSE <17 mm was noticed in both patients managed initially conservatively (adjusted HR, 1.46 [95% CI, 1.20–1.76]) and patients who underwent early (within 3 months after diagnosis) AVR (adjusted HR, 1.61 [95% CI, 1.03–2.52]). In asymptomatic patients with severe AS and preserved ejection fraction, TAPSE <17 mm was independently predictive of mortality (adjusted HR, 2.14 [95% CI, 1.31–3.51]). Early AVR was associated with similar survival benefit in TAPSE <17 and ≥17 mm (adjusted HR, 0.23 [95% CI, 0.16–0.34] for TAPSE <17 mm, adjusted HR, 0.26 [95% CI, 0.19–0.35] for TAPSE ≥17 mm;
P
for interaction, 0.97).

Conclusions:
Right ventricular dysfunction is an important and independent predictor of mortality in AS. TAPSE <17 mm at the time of AS diagnosis is a marker of poor survival under conservative management and after AVR even in asymptomatic patients with severe AS. AVR was associated with a pronounced reduction in mortality independent of TAPSE suggesting that AVR should be discussed before right ventricular dysfunction occurs in severe AS.
Preoperative Predictors of Response to Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea
Authors: Xiao Roy , Trask Douglas K. , Kominsky Alan H. 
Published: January 2020

ObjectiveHypoglossal nerve stimulation (HGNS) is an effective treatment for patients with obstructive sleep apnea (OSA) who fail continuous positive airway pressure (CPAP). We assessed the relationship between patient characteristics and response to HGNS.Study DesignRetrospective cohort study.SettingSingle tertiary care institution.Subjects and MethodsThis study included CPAP‐intolerant patients with moderate to severe OSA after HGNS system implantation from November 2015 to December 2017. Patient measures, drug‐induced sleep endoscopy (DISE) findings, and apnea‐hypopnea indices (AHIs) were recorded.ResultsForty‐eight patients underwent implantation with the following median measures: age, 66 years; body mass index, 28.6; and neck circumference, 41.0 cm. Patients were classified by Friedman tongue position (II, 27%; III, 56%; IV, 17%) and Mallampati grade (I, 25%; II, 50%; III, 23%; IV, 2%). By DISE, 71% had anterior‐posterior palatal collapse. Additionally, 38% had lateral oropharynx collapse; 50%, tongue base collapse; and 27%, epiglottis collapse. Following implantation, median AHI improved from 38.5 to 2.7 (P <. 001), and 92% of patients had no worse than mild OSA (8% moderate). Patients with Friedman tongue position grade II/III experienced greater change in AHI as compared with grade IV (94.2% vs 73.8%, P <. 001). Patients with Mallampati score I/II experienced greater improvement versus score III/IV (94.7% vs 66.5%, P <. 001). No DISE findings, including any obstruction or collapse, were associated with change in AHI.ConclusionThis study further confirms HGNS as an effective treatment of CPAP‐intolerant OSA. Office measures such as Friedman tongue position IV and Mallampati III/IV were associated with mildly decreased response. DISE findings were not associated with patient response.
Comparison of Interproximal Reduction Techniques and Proximal Strips: An Atomic Force Microscopic and Confocal Microscopic Study
Authors: S Pooja Harish , C Karunakara B , Reddy Sumitra 
Published: January 2020

Objective: A vivo study was conducted to evaluate the surface roughness produced by two different methods: hand-held mechanical and air-rotor stripping and also by HORICO and Ortho-Organizer strips (Bengaluru, India), before and after polishing with 3M Sof-Lex Finishing Strips under Atomic Force Microscope. Methodology: Study included 44 proximal surfaces of extracted premolars divided into a control group and 3 experimental groups with 12 surfaces in each. Hand-held mechanical stripping was done by 40 passages of 6 cm long abrasive strips and air-rotor stripping using high-speed air-rotor turbine hand piece. Polishing was done using 3M Sof-Lex finishing strips. Reduced teeth samples were viewed under Atomic Force Microscope and the proximal strips under Confocal microscope for surface roughness. Results: Air-rotor stripping produced statistically significant more surface roughness compared to the mechanical reduction technique ( P = .01). There was no significant difference between the roughnesses produced by 2 different proximal strips. Tooth surface after IPR with polishing had less roughness compared to unpolished surface. There was no mean difference between the wear of proximal strips. Conclusion: The mechanical reduction technique of interproximal surface produces less surface roughness compared to air-rotor stripping. Polishing with 3M Sof-Lex strips after reduction irrespective of the technique and material used gives smoother surface than even normal enamel.
Medical student perceptions of physical and emotional safety before and after 5-week mental health placements
Authors: Gallan Ben , Dawes Kerry , Thomas Susan J 
Published: January 2020

Objective: Understanding whether medical students feel safe in mental health placements is important to delivering effective and engaging training experiences. Method: Second year students completed anonymous online surveys before ( n = 37) and after ( n = 41) mental health placements, to gather qualitative and quantitative data about their sense of physical and emotional safety, and factors that positively and negatively influenced their experiences. Data were analysed using chi square and content analysis. Results: There was a disparity between students’ expectations of physical and emotional safety before placements and their actual experience. Following placement, no students reported that they felt physically ‘unsafe’ or ‘very unsafe’. Conversely, over 20% of students indicated that they had felt emotionally unsafe during their placement. When asked to compare their expectations prior to placement with their actual experience, over 13% felt ‘much less safe’ emotionally, where no participants felt ‘much less safe’ physically. Qualitative content identified included exposure to patients’ tragic life stories, aggression, the physical ward environment and adequacy of supports. Conclusions: The distinction between physical and emotional safety is a valuable framework through which to understand the student experience of clinical placements in psychiatry and to seek to best support students. The data provide rich insight into students’ experiences, particularly emotional challenges, on psychiatry wards.
Evaluation of Multidisciplinary Team Clinic for Patients With Isolated Cleft Lip
Authors: Padovano William M. , Snyder-Warwick Alison K. , Skolnick Gary B. , Pfeifauf Kristin D. , Menezes Maithilee D. , Grames Lynn M. , Cheung Susan , Kim Andrew M. , Cradock Mary Michaeleen , Naidoo Sybill D. , Patel Kamlesh B. 
Published: January 2020

Objective: To report the incidences of secondary lip and nose operations, otolaryngology procedures, speech-language therapy, neurodevelopmental concerns, and dental and orthodontic issues in children with isolated cleft lip to inform multidisciplinary cleft team protocols. Setting: An American Cleft Palate-Craniofacial Association–approved team at a tertiary academic children’s hospital. Design: Retrospective cohort study of patients evaluated through longitudinal clinic visits by a multidisciplinary cleft palate and craniofacial team between January 2000 and June 2018. Patients, Participants: Children with nonsyndromic cleft lip with or without cleft alveolus (n = 92). Results: Median age at final team visit was 4.9 years (interquartile range: 2.4-8.2 years). Secondary plastic surgery procedures were most common between ages 3 and 5 (135 per 1000 person-years), and the majority of these procedures were minor lip revisions. The rate of tympanostomy tube insertion was highest before age 3 (122 per 1000 person-years). By their final team visit, 88% of patients had normal hearing and 11% had only slight to mild conductive hearing loss. No patients had speech errors attributable to lip abnormalities. Psychological interventions, learning disabilities, and dental or orthodontic concerns were uncommon. Conclusions: Most patients with isolated cleft lip may not require long-term, longitudinal evaluation by cleft team specialists. Cleft teams should develop limited follow-up protocols for these children to improve resource allocation and promote value-based care in this patient population.
Quantitative optical coherence tomography angiography: A review
Authors: Yao Xincheng , Alam Minhaj N , Le David , Toslak Devrim 
Published: January 2020

As a new optical coherence tomography (OCT) modality, OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. By providing unparalleled capability to differentiate individual plexus layers in the retina, OCTA has demonstrated its excellence in clinical management of diabetic retinopathy, glaucoma, sickle cell retinopathy, diabetic macular edema, and other eye diseases. Quantitative OCTA analysis of retinal and choroidal vasculatures is essential to standardize objective interpretations of clinical outcome. Quantitative features, including blood vessel tortuosity, blood vessel caliber, blood vessel density, vessel perimeter index, fovea avascular zone area, fovea avascular zone contour irregularity, vessel branching coefficient, vessel branching angle, branching width ratio, and choroidal vascular analysis have been established for objective OCTA assessment. Moreover, differential artery–vein analysis has been recently demonstrated to improve OCTA performance for objective detection and classification of eye diseases. In this review, technical rationales and clinical applications of these quantitative OCTA features are summarized, and future prospects for using these quantitative OCTA features for artificial intelligence classification of eye conditions are discussed.Impact statementOCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. Quantitative analysis of OCTA is essential to standardize objective interpretations of clinical outcome. This review summarizes technical rationales and clinical applications of quantitative OCTA features.
Epidemiology of stroke in urban northeast China: A population-based study 2018–2019
Authors: Xing Liying , Jing Li , Tian Yuanmeng , Wang Weizhong , Sun Jixu , Jiang Cuiqin , Shi Lei , Dai Dong , Liu Shuang 
Published: January 2020

Background Stroke has been emerging as the major public health challenge in China. In the present study, we sought to comprehensively estimate of stroke burden in urban northeast China. Methods We conducted the cross-sectional study in 5424 adults aged ≥ 40 years (response rate was 85.3%) living in urban northeast China. A multi-stage cluster sampling method was employed to ensure the population was representative. The prevalent stroke patients were defined as survivors on 31 March 2018. Stroke was defined based on the WHO criteria and was classified into ischemic stroke (IS) and hemorrhage stroke (HS) according to the imaging results. Results A total of 292 stroke cases were confirmed (IS-260, 35-HS, and IS concomitant HS-3). Crude prevalence of overall stroke, IS and HS were 5.4%, 4.8% and 0.6%, respectively, and the age-standardized prevalence was 3.8%, 3.4% and 0.5%, respectively. The prevalence of stroke was significantly higher in men compared to women. Among stroke population, 4.5% had disabilities and lived with consequences of stroke. Hypertension, dyslipidemia and diabetes were highly prevalent, accounting for 80.5%, 59.7% and 39.3%, respectively, in stroke population. However, the control rates of those comorbidities were unacceptably low (13.2%, 8.1% and 40.4%, respectively). Conclusion The considerable stroke burden was observed in urban northeast China with high proportion of stroke and related risk factors. Poorly controlled comorbidities are likely to contribute to the substantial burden in the future. Long-term primary and secondary prevention should be highlighted in urban northeast China.
Is the Landing Error Scoring System Reliable and Valid? A Systematic Review
Authors: Hanzlíková Ivana , Hébert-Losier Kim 
Published: January 2020

Context: The Landing Error Scoring System (LESS) is a clinical tool often used in research and practice to identify athletes presenting high injury-risk biomechanical patterns during a jump-landing task. Objective: To systematically review the literature addressing the psychometric properties of the LESS. Data Sources: Three electronic databases (PubMed, Web of Science, and Scopus) were searched on March 28, 2018, using the term “Landing Error Scoring System.” Study Selection: All studies using the LESS as main outcome measure and addressing its reliability, validity against motion capture system, and predictive validity were included. Original English-language studies published in peer-reviewed journals were reviewed. Studies using modified versions of the LESS were excluded. Study Design: Systematic literature review. Level of Evidence: Level 4. Data Extraction: Study design, population, LESS testing procedures, LESS scores, statistical analysis, and main results were extracted from studies using a standardized template. Results: Ten studies met inclusion criteria and were appraised using Newcastle-Ottawa Quality Assessment Scale adapted for cross-sectional studies. The overall LESS score demonstrated good-to-excellent intrarater (intraclass correlation coefficient [ICC], 0.82-0.99), interrater (ICC, 0.83-0.92), and intersession reliability (ICC, 0.81). The validity of the overall LESS score against 3-dimensional jump-landing biomechanics was good when individuals were divided into 4 quartiles based on LESS scores. The validity of individual LESS items versus 3-dimensional motion capture data was moderate-to-excellent for most of the items addressing key risk factors for anterior cruciate ligament (ACL) injury. The predictive value of the LESS for ACL and other noncontact lower-extremity injuries remains uncertain based on the current scientific evidence. Conclusion: The LESS is a reliable screening tool. However, further work is needed to improve the LESS validity against motion capture system and confirm its predictive validity for ACL and other noncontact lower-extremity injuries.
Association between upper extremity dysfunction and sleep disturbance in an elderly general population
Authors: Tajika Tsuyoshi , Kuboi Takuro , Endo Fumitaka , Shinagawa Satoshi , Kobayashi Hiroki , Hashimoto Shogo , Sakane Hideo , Hamano Noritaka , Sasaki Tsuyoshi , Ichinose Tsuyoshi , Shitara Hitoshi , Chikuda Hirotaka 
Published: January 2020

Objective: Several upper extremity disorders are associated with sleep disturbance in patient populations. This study evaluated the relation between self-assessment of upper extremity function and sleep disturbance in an elderly general population. Methods: A total of 159 participants (56 men, 103 women, 38–88 years old, mean age of 66.4 years) completed a self-administered questionnaire including items for sex, weight, height, and dominant hand. Upper extremity dysfunction was investigated using Quick Disabilities of the Arm, Shoulder, and Hand of the Japanese Society for Surgery of the Hand. The sleep disturbance severity was evaluated using a Japanese version of the Athens Insomnia Scale. Quality of life was assessed using the EuroQol-5-dimension-3-level, Japanese version. We measured the bilateral hand grip as an indicator of hand muscle function. Statistical tests were applied to clarify the association between upper extremity dysfunction and screening results for sleep disturbance. Results: Of 159 participants, 45 (28.3%) had sleep disturbance as assessed using Japanese version of the Athens Insomnia Scale (11 men and 34 women; mean age of 68.1 years). Japanese version of the Athens Insomnia Scale scores correlated with the EuroQol index; EuroQol visual analog scale; and Quick Disabilities of the Arm, Shoulder, and Hand scores. The Quick Disabilities of the Arm, Shoulder, and Hand score and dominant grip strength of the participants with sleep disturbance were significantly higher than those of the no sleep disturbance group. The EuroQol index score and visual analog scale of those reporting a sleep disturbance were significantly lower than those of the no sleep disturbance group. Conclusion: Self-administered upper extremity health condition as assessed using Quick Disabilities of the Arm, Shoulder, and Hand correlated with sleep disturbance. Our results suggest a link between upper extremity conditions and sleep disturbance.
Maletoyvayamite, Au3Se4Te6, a new mineral from Maletoyvayam deposit, Kamchatka peninsula, Russia
Authors: Tolstykh Nadhezda D. , Tuhý Marek , Vymazalová Anna , Plášil Jakub , Laufek František , Kasatkin Anatoly V. , Nestola Fabrizio , Bobrova Olga V. 
Published: January 2020

AbstractMaletoyvayamite, Au3Se4Te6, is a new mineral discovered in a heavy-mineral concentrate from the Gaching occurrence of the Maletoyvayam deposit, Kamchatka, Russia (60°19′51.87″N, 164°46′25.65″E). It forms anhedral grains (10 to 50 μm in size) and is found in intergrowths with native gold (Au–Ag), Au tellurides (calaverite), unnamed phases (AuSe, Au2TeSe and Au oxide), native tellurium, sulfosalts (tennantite, tetrahedrite, goldfieldite and watanabeite) and supergene tripuhyite. Maletoyvayamite has a good cleavage on {010} and {001}. In plane-polarised light, maletoyvayamite is grey, has strong bireflectance (grey to bluish grey), and strong anisotropy; it exhibits no internal reflections. Reflectance values for maletoyvayamite in air (Rmin,Rmaxin %) are: 38.9, 39.1 at 470 nm; 39.3, 39.5 at 546 nm; 39.3, 39.6 at 589 nm; and 39.4, 39.7 at 650 nm. Sixteen electron-microprobe analyses of maletoyvayamite gave an average composition: Au 34.46, Se 16.76, Te 47.23 and S 0.84, total 99.29 wt.%, corresponding to the formula Au2.90(Se3.52S0.44)Σ3.96Te6.14based on 13 atoms; the average of eleven analyses on synthetic analogue is: Au 34.20, Se 19.68 and Te 45.42, total 99.30 wt.%, corresponding to Au2.90Se4.16Te5.94. The calculated density is 7.98 g/cm3. The mineral is triclinic, space groupP1, witha= 8.901(2),b= 9.0451(14),c= 9.265(4) Å, α = 97.66(3), β = 106.70(2), γ = 101.399(14)°,V= 685.9(4) Å3andZ= 2. The crystal structure of maletoyvayamite represents a unique structure type resembling a molecular structure. There are cube-like [Au6Se8Te12] clusters linkedviavan der Waals interactions. The structural identity of maletoyvayamite with the synthetic Au3Se4Te6was confirmed by powder X-ray diffraction and Raman spectroscopy.
Integrated Care Search: development and validation of a PubMed search filter for retrieving the integrated care research evidence
Authors: Damarell Raechel A. , Lewis Suzanne , Trenerry Camilla , Tieman Jennifer J. 
Published: January 2020

Abstract
Background
Integrated care is an increasingly important principle for organising healthcare. Integrated care models show promise in reducing resource wastage and service fragmentation whilst improving the accessibility, patient-centredness and quality of care for patients. Those needing reliable access to the growing research evidence base for integrated care can be frustrated by search challenges reflective of the topic’s complexity. The aim of this study is to report the empirical development and validation of two search filters for rapid and effective retrieval of integrated care evidence in PubMed. One filter is optimised for recall and the other for precision.

Methods
An Expert Advisory Group comprising international integrated care experts guided the study. A gold standard test set of citations was formed from screening Handbook Integrated Care chapter references for relevance. This set was divided into a Term Identification Set (20%) for determining candidate terms using frequency analysis; a Filter Development Set (40%) for testing performance of term combinations; and a Filter Validation Set (40%) reserved for confirming final filter performance. In developing the high recall filter, recall was steadily increased while maintaining precision at ≥50%. Similarly, the high precision filter sought to maximise precision while keeping recall ≥50%. For each term combination tested, an approximation of precision was obtained by reviewing the first 100 citations retrieved in Medline for relevance.

Results
The gold standard set comprised 534 citations. The search filter optimised for recall (‘Broad Integrated Care Search’) achieved 86.0–88.3% recall with corresponding low precision (47–53%). The search filter optimised for precise searching (‘Narrow Integrated Care Search’) demonstrated precision of 73–95% with recall reduced to between 55.9 and 59.8%. These filters are now available as one-click URL hyperlinks in the website of International Foundation for Integrated Care.

Conclusions
The Broad and Narrow Integrated Care Search filters provide potential users, such as policy makers and researchers, seamless, reliable and ongoing access to integrated care evidence for decision making. These filters were developed according to a rigorous and transparent methodology designed to circumvent the challenges of information retrieval posed by this complex, multifaceted topic.