bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory Activity of the Gel Containing a Combination of Neem Leaf Extract and Shallot Extract
Authors: Nurmala Sara , Moerfiah Moerfiah , Purnama Restu T. 
Published: May 2020

Neem leaves (Azadirahcta indica A. Juss) and shallots (Allium cepa L) contain flavonoids that are effective as an antioxidant, antibacterial, and anti-inflammatory. The aim of this study was to determine the effective concentration and the duration of treatment of the anti-inflammatory activity of the gel containing a combination of neem leaf extract and shallot extract. These substances have a similar effect, and it is believed that these combinations may effective as an anti-inflammatory at small doses to reduce the side effects. The animals were randomly divided into 6 groups with 5 rats per group. The rats were wound-induced by incising its back (length 1.5 cm, depth 0.7 mm) and were observed for 8 days. Parameters measured were wound’s closure, color, and healing process. Statistical analysis showed that the most effective concentration as an anti-inflammatory was formula 1 (neem leaf extract 3.125%: shallots extract 4%) with the fastest healing time was 5 days. Thus, this formula is one of the effective treatment options for healing wounds.Keywords: neem leaves, shallots, anti-inflammatory, combination, gel
Knowledge, Attitude and Practice of Insulin Use of Diabetic Patients in India
Authors: A P Venkataraman , Kamath Laxminarayana , Shankar Samhita 
Published: May 2020

Diabetes mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. India is emerging as the world diabetic capital. Insulin is a therapeutic option to treat either type 1 and type 2 DM. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence. The present study was done to assess the knowledge, attitude, and practice regarding insulin use among diabetic patients at Victoria Hospital, Bangalore, India. Knowledge, attitude, and practice of sixty diabetic patients (either inpatients or outpatients) were assessed by using a validated questionnaire consisting of 24 items. Scores were allotted to each question and evaluated after applying appropriate statistical tests. The mean age of the patients was 53.51±6.48 years (58.33% males). The mean knowledge score was 9.06±1.88 out of 22, attitude score was 4.78±1.37 out of 12 and practice score was 7.75±1.24 out of 11. The mean score of attitude was better in females compared to male patients (5.32±1.34 vs. 4.4±1.28). Male patients scored 38.57% compared to female patients (41.33%) for the question regarding symptoms of hypoglycemia. 57.14% of male patients and 72% of female patients carried simple carbohydrates when going out. Despite good practice scores, the knowledge and attitude scores regarding insulin use were inadequate. Potential adverse effects of insulin can be avoided and better knowledge, attitude, and practice can be achieved by providing proper education to patients. Keywords: knowledge, attitude, practice, diabetic, insulin
The Pharmacokinetic Drug-Drug Interactions of Andrographis paniculata and Ibuprofen in the Plasma of Healthy Oryctolagus cuniculus Rabbits
Authors: Mutakin Mutakin , Megantara Sandra , Larasati Batari A. , Yogiyanto Yogiyanto , Levita Jutti , Ibrahim Slamet 
Published: May 2020

An HPLC method was developed and validated for the pharmacokinetic drug-drug interaction between Andrographis paniculata and ibuprofen in the plasma of Oryctolagus cuniculus rabbits after a single oral administration of the mixture. Nine healthy rabbits (6 males and 3 females, weight 1.68-2.42 kg) were acclimatized for 7 days and were randomly divided into 3 groups. At day-8th the rabbits were group (1) treated with a single oral administration of ibuprofen (dose of 28 mg/kg BW); group (2) treated with a single oral administration of Andrographis paniculata infusion (7.04 mL/kg BW); group (3) treated with a single oral administration of a mixture of Andrographis paniculata (7.04 mL/kg BW) infusion and ibuprofen (dose of 28 mg/kg BW). Plasma samples were prepared by collecting the blood from the marginal ear vein at 0, 30, 60, 90, and 120 minutes after the mixture administration, followed by centrifuging it for 30 minutes 3000 rpm. Chromatographic separation was performed on a LiChrosorb RP-18 with methanol and double-distilled water (70:30) as the mobile phase, flow rate 1 mL/minute. UV detection was set at 227 nm. The absorption and distribution of ibuprofen were fast (Tmax = 30 min; Cmax = 4.02962 mcg/mL), however, interestingly this drug could improve the absorption and distribution of andrographolide in Oryctolagus cuniculus rabbits
Effect of Alginate and Polyethylene Glycol Addition on Physical and Mechanical Characteristics of k-Carrageenan-based Edible Film
Authors: Giyatmi Giyatmi , Poetri Tika Annisa Eka , Irianto Hari Eko , Fransiska Dina , Agusman Agusman 
Published: May 2020

Waste disposal problems have attracted scientists around the world to explore the use of renewable resources to produce biodegradable films and coatings. Indonesia has diverse renewable resources of biopolymers that originated from seaweeds such as carrageenan, agar, and alginate. Carrageenan is considered as a potential biopolymer for edible film manufacture due to its characteristic range. This study aimed to develop carrageenan-based edible film using alginate and polyethylene glycol as plasticizers. Edible film made from k-carrageenan with the addition of alginate and polyethylene glycol (PEG) as plasticizers was tested for its mechanical properties, water vapor transmission rate (WVTR) and water solubility. Blending k-carrageenan with alginate (0%, 0.25%, 0.5%, 0.75%, and 1.0% w/v) increased tensile strength, thickness, and water solubility, but reduced elongation at break, WVTR, and moisture content. The addition of PEG (1%, 2%, and 3% w/v) reduced tensile strength and water solubility, but increased elongation at break, thickness, and moisture content. This study recommended that the best carrageenan-based edible film was obtained from a formula using 1% alginate (w/v) and 1% PEG (w/v).
Safety and Feasibility of Additional Tumor Debulking to First-Line Palliative Combination Chemotherapy for Patients with Multiorgan Metastatic Colorectal Cancer
Authors: Gootjes Elske C. , van der Stok Eric P. , Buffart Tineke E. , Bakkerus Lotte , Labots Mariette , Zonderhuis Barbara M. , Tuynman Jurriaan B. , Meijerink Martijn R. , van de Ven Peter M. , Haasbeek Cornelis J.A. , ten Tije Albert J. , de Groot Jan-Willem B. , Hendriks Mathijs P. , van Meerten Esther , Nuyttens Joost J.M.E. , Grunhagen Dirk J. , Verhoef Cornelis , Verheul Henk M.W. ,   on behalf of the ORCHESTRA study group
Published: June 2020

Abstract

Introduction
Local treatment of metastases is frequently performed in patients with multiorgan metastatic colorectal carcinoma (mCRC) analogous to selected patients with oligometastatic disease for whom this is standard of care. The ORCHESTRA trial (NCT01792934) was designed to prospectively evaluate overall survival benefit from tumor debulking in addition to chemotherapy in patients with multiorgan mCRC. Here, we report the preplanned safety and feasibility evaluation after inclusion of the first 100 patients.

Methods
Patients were eligible if at least 80% tumor debulking was deemed feasible by resection, radiotherapy and/or thermal ablative therapy. In case of clinical benefit after three or four cycles of respectively 5-fluorouracil/leucovorin or capecitabine and oxaliplatin ± bevacizumab patients were randomized to tumor debulking followed by chemotherapy in the intervention arm, or standard treatment with chemotherapy.

Results
Twelve patients dropped out prior to randomization for various reasons. Eighty-eight patients were randomized to the standard (n = 43) or intervention arm (n = 45). No patients withdrew after randomization. Debulking was performed in 82% (n = 37). Two patients had no lesions left to treat, five had progressive disease, and one patient died prior to local treatment. In 15 patients (40%) 21 serious adverse events related to debulking were reported. Postoperative mortality was 2.7% (n = 1). After debulking chemotherapy was resumed in 89% of patients.

Conclusion
Tumor debulking is feasible and does not prohibit administration of palliative chemotherapy in the majority of patients with multiorgan mCRC, despite the occurrence of serious adverse events related to local treatment.

Implications for Practice
This first prospective randomized trial on tumor debulking in addition to chemotherapy shows that local treatment of metastases is feasible in patients with multiorgan metastatic colorectal cancer and does not prohibit administration of palliative systemic therapy, despite the occurrence of serious adverse events related to local treatment. The trial continues accrual, and overall survival (OS) data and quality of life assessment are collected to determine whether the primary aim of &gt;6 months OS benefit with preserved quality of life will be met. This will support evidence-based decision making in multidisciplinary colorectal cancer care and can be readily implemented in daily practice.
Hepatitis C Virus Infection and Chemotherapy in Breast Cancer: A Retrospective Chart Analysis
Authors: Ghosh Saptaparni , Chen Minghua L. , Weinberg Janice , Fikre Tsion , Ko Naomi Y. 
Published: June 2020

Abstract

Background
Breast cancer and hepatitis C virus (HCV) infection are major health problems in the U.S. Despite these highly prevalent diseases, there is limited information on the effect of HCV infection among patients with breast cancer receiving chemotherapy and the potential challenges they face during treatment. Currently, there are no guidelines for chemotherapy administration in HCV-positive patients with breast cancer.

Materials and Methods
We performed a retrospective case–control analysis on six patients with breast cancer with active HCV infection and 12 HCV-negative matched controls who received chemotherapy between January 2000 and April 2015. We investigated dose delays, dose changes, hospitalization, hematologic reasons for dose delays, and variation in blood counts during chemotherapy from the patients’ medical records. Fisher's exact test was used for statistical comparison of the outcome variables between the two groups.

Results
When compared with the HCV-negative patients, the HCV-positive group was at a significantly higher risk of dose delays (100% vs. 33%, p value .013), dose changes (67% vs. 8%, p value .022), hospitalization during chemotherapy (83% vs. 25%, p value .043), and hematotoxicity related dose delays (83% vs. 8%, p value .003). HCV-positive patients took a longer time to complete treatment than the HCV-negative group.

Conclusion
Patients with HCV receiving chemotherapy for breast cancer are more likely to experience complications such as dose delays, dose modifications, and hospitalization. Future studies to confirm our findings and investigate on the effect of concurrent HCV and breast cancer treatment are warranted.
KEMAMPUAN VO2 MAX DAN KEMAMPUAN PEMULIHAN ATLET PENCAK SILAT
Authors: SUTISNA ROMI , Imanudin Iman 
Published: June 2020

This study discusses the relationship of vo2 max capability and the ability of martial arts athletes recovery, the instrument used in this study by using balke test to measure vo2 max and using polar to calculate the pulse. The purpose of this study is to determine and explain whether there is a relationship between the ability of vo2 max and the ability of the athletes recovery pencak silat In this study the researchers chose purposive sampling as the appropriate technique for sampling which researchers took the selected people according to the specific characteristics possessed by the sample that as many as 10 men athletes based on research needs. Research instruments used are data analysis. This research is located in Bandung, West Java precisely at the stadium of Universitas Pendidikan Indonesia, The result states that VO2 Max from the lowest to the highest is 35.6-47.5 and the recovery pulse from the lowest to the highest is 115-159. The results of data processing showed the following discovery: "There is no significant relationship between VO2 Max and the recovery ability of the athlete of pencaksilat". Kata kunci : Vo2 Max, pencak silat recovery
Comparision of analgesic efficacy of ropivacaine and bupivacaine in rectus sheath block for midline abdominal surgeries
Authors: Kumar Raiger Lalit , Kuldeep Arti , Gehlot Ravindra , Sharma Mukesh , Gopal Jangir Krishan 
Published: June 2020

In the modern setting the rectus sheath block (RSB) has been found effective in decreasing opioid requirement after both diagnostic and interventional laparoscopy and laparotomy. Efficacy of rectus sheath block (RSB) using ropivacaine versus bupivacaine for acute postoperative pain relief is not much investigated. 90 patients undergoing elective midline abdominal surgeries under general anaesthesia were randomly divided into three groups of 30 patients each, destined to receive bilateral rectus sheath block using 15 ml on each side (total 30 ml) of 0.25% ropivacaine in Group R, 0.25% bupivacaine in Group B or normal saline in Group C. Three groups were compared regarding time to first rescue analgesic from time of RSB (duration of analgesia), total rescue analgesic (tramadol) consumption in first 10 hours, visual analogue score (VAS), satisfaction score and adverse effects. Mean duration of analgesia was significantly longer in group R (5.78±0.93h) than group B (3.63±0.90 h) and group C (2.37±0.44 h), p&#60;0.001 (group R &#62; group B &#62; group C). This trend was observed in both hernia repair and laparotomy. Rescue analgesic consumption in terms of number of doses was significantly less in Group R (30) than in Group B (38) than in Group C (59), p&#60;0.05. Mean VAS was significantly less and patient satisfaction was significantly better in Group R than in Group B than in Group C, (p&#60;0.001) Bilateral single shot rectus sheath block (RSB) using isobaric ropivacaine (0.25%) or bupivacaine (0.25%) is a safe and effective method of providing postoperative analgesia to patients undergoing midline abdominal surgeries. The lower cardio toxicity profile with the excellent prolonged postoperative analgesia makes ropivacaine an excellent choice for the RSB as compared to bupivacaine
TRENDS IN LEGAL REGULATION OF SOCIAL PROTECTION AS A PILLAR OF DECENT WORK AND A MOVING FORCE OF SUSTAINABLE DEVELOPMENT
Authors: Vyshnovetska Svitlana , Amelicheva Liliya , Olefir Viktor , Ierko Galyna , Petrenko Ganna 
Published: May 2020

Purpose of the study: The purpose of the article is to identify trends in the legal regulation of social protection at the global, regional and national levels in the process of achieving decent work and sustainable development. The object of the study is the sphere of social protection as a pillar of decent work and a moving force of sustainable development, and its subject is the mechanisms of legal regulation of this sphere at the global, regional, and national levels.
Methodology: The methodological basis of the research is dialectics, synergies, and hermeneutics. The research methods cover a system of general scientific and special legal means and methods of knowledge, method of abstraction and generalization, analytical, formal-logical, and logical-semantic approaches.
Main Findings: It is proved that it is advisable to apply a synergistic approach to identifying and defining trends in the legal regulation of social protection as a pillar of decent work and a moving force of sustainable development. It is determined that in developed, developing countries and countries with economies in transition, there is a need to prepare modern National Social Protection Strategies at the legislative level or to improve existing strategies, taking into account the provisions of the 2030 Sustainable Development Programme and the ILO Decent Work Programme.
Applications of this study: The results of this research can be used to formulate public policy in social security and labor in Ukraine. Ideological findings will improve labor legislation. The research algorithm will be useful for students as well as graduate students in the study of labor law problems.
Novelty/Originality of this study: The originality of this research is the use of a synergistic approach for the consideration of social protection as the foundation of decent work and the moving force of sustainable development. This approach is unconventional in the science of labor law. It helped to identify important areas for improvement of legal regulation of social protection at the global, regional, and national levels.
CA. de endometrio en pacientes jóvenes
Authors: Uribe E. Gabriel Fernando , Tobón L. Gabriel Alberto , García M. Jaime , Diaz de C. Constanza 
Published: June 2020

Hasta hace unos pocos años, el carcinoma de endometrio en pacientes menores de 40 años era una curiosidad médica. Se hace una revisión de las causas predisponentes entre las cuales se describen: 1 . Tumores funcionantes de ovario2. Enfermedad poliquística del ovario 3. Terapia estrogénica4. Ingestión prolongada de anovulatorios. Se presenta el caso de una paciente de 25 años vista en el Consultorio médico Departamental, a quien se le practicó anexo histerectomía por un Ca. de endometrio. Se discute el estudio anatomopatológico. Se hace un análisis de la influencia de los estrógenos en el carcinoma de endometrio. Se discute el tratamiento comparando el médico y el quirúrgico. Por último se deja el interrogante sobre terapia de sustitución en estas pacientes.
Peran Terapi Wudhu Terhadap Kestabilan Emosi Klien Pusat Rehabilitasi Narkoba Ar Rahman Palembang
Authors: Oktaryanto Vicky , Rusli Risan , Yudiani Ema 
Published: May 2020

This research aims to determine if there is a therapeutic influence of wudu to the emotional stability of the clients of the Ar Rahman Drug Rehabilitation Center. The hypothesis proposed in this study is that there is a therapeutic effect of wudu on emotional stability. The sample of this study was the client of the Ar Rahman Drug rehabilitation Centre Palembang which numbered 16 people divided into two groups, the experimental group and the control group. The type of research used is pure experiments with Pretest design posttest Control Group Design. The technique used is simple random sampling. The data in this study was analyzed with the Independent sample T-Test, from the data analysis results obtained a significant effect of therapy wudu to emotional stability with the value of ρ = 0.001 (ρ < 0.05) and value T = 4,400. Based on the results, it can be concluded that wudu therapy affects the client's emotional stability of the Ar Rahman Drug Rehabilitation Center Palembang.
An analysis of Accelerated Christian Curriculum in Biblical Christian Worldview
Authors: Liana Linda 
Published: May 2020

<p class="abstracttextDILIGENTIA">God gave man his commission (Gen. 1:26-30), called the Cultural Mandate. In this mandate mankind is to steward the created order, in accordance with God’s law-Word, for God’s glory. Shortly before the resurrected Lord Jesus Christ ascended to heaven, he issued the Great Commission (Matt. 28:18-20). The Great Commission command to disciple all the nations into obedience to the comprehensive and absolute lordship of Jesus Christ. There is no area of thought, life, or culture outside the scope of the Creation/ Dominion Mandate or the Great Commission. Thus, the extent of the Creation Mandate and the extent of the Great Commission necessitate Christian Education.<strong> </strong>Accelerated Christian Curriculum is a curriculum that has been helping pastors and parents by developing and publishing quality, character building Christian educational materials for Grade Levels K3-12. By integrating character building principles and scripture memory into the academics, the program helps children master each concept before moving to the next concept.<strong> </strong>In this essay I analyze the Accelerated Christian Education curriculum from a Biblical Christian Worldview.</p><div><div><p class="footnoteDILIGENTIA"> </p></div></div>
Aprendizagem em arte e celulares
Authors: Silva Tácia Graciele de Albuquerque , Pinto Anamelea de Campos 
Published: May 2020

Este trabalho tem como tema as formas de interação em nível pessoal e técnico que se constituíram na aprendizagem em Arte com a utilização de dispositivos móveis. Buscando responder a seguinte problemática: Quais interações se formam na aprendizagem em Arte com dispositivos móveis? Para constituir esse estudo foram articuladas as noções interação e experiência segundo Jonh Dewey aplicadas na abordagem triangular no ensino de Arte concebida por Ana Mae Barbosa. Este artigo é um recorte de uma pesquisa, que se deu em parceria com um professor-mediador de Arte em uma Escola Estadual, por meio de uma pesquisa-intervenção com 42 adolescentes e jovens entre 15 e 20 anos. Durante a Pesquisa, foram realizadas intervenções (4 desafios fotográficos) para aprimoramento da percepção técnica-estética em Arte e as fotografias de autorias desses jovens foram organizadas numa exposição, envolvendo toda a comunidade escolar. Os dados foram levantados com os instrumentos de diário de campo, questionários, entrevistas e grupos focais além do registro audiovisual e fotográfico. Realizamos a análise categorial focando na interação durante a aprendizagem em Arte/Educação. Como resultados obtemos um grande escopo imagético produzido pelos participantes sobre suas realidades e a própria escola, além uma trilha metodológica que pode auxiliar na utilização dessas tecnologias a outros profissionais. Mas em destaque, elucidamos a potencialidade de criação artística com dispositivos móveis, a percepção de uma sensibilidade no olhar estético ao produzir fotos e a colaboração grupal vivenciada no decorrer do projeto.
Migrasi Desa-Kota di Indonesia: “Risk Coping Strategy VS Investment”
Authors: Marta Joan , Fauzi Akhmad , Juanda Bambang , Rustiadi Ernan 
Published: May 2020

The study aims to analyses the reasons behind migrations motives among rural household based on household and area origin characteristic. The study used IFLS data of 2007 and 2014 consisting 2,581 household samples spreading in 13 provinces. Binomial and multinomial logit model was used to estimate probability to migrate based on migration motive. We found the contradictory effect of household income on decision to migrate between motives. Income has negative effect in risk coping as migration motives, otherwise have positive effect in investment motive. --------------------------------------- Penelitian ini bertujuan untuk menganalisis alasan dibalik motif migrasi di antara rumah tangga perdesaan berdasarkan karakteristik rumah tangga dan karakteristik daerah asal. Penelitian ini menggunakan data IFLS tahun 2007 dan 2014 yang terdiri dari 2.581 sampel rumah tangga yang tersebar di 13 provinsi. Model binomial dan multinomial logit digunakan untuk memperkirakan probabilitas untuk bermigrasi berdasarkan motif migrasi. Hasil penelitian ini menemukan efek kontradiktif dari pendapatan rumah tangga pada keputusan untuk bermigrasi di antara motif. Pendapatan memiliki efek negatif dalam mengatasi risiko sebagai motif migrasi, sebaliknya memiliki efek positif dalam motif investasi.