bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of integrated positron emission tomography/magnetic resonance imaging in evaluating the prognostic factors of head and neck squamous cell carcinoma with positron emission tomography, diffusion-weighted imaging, dynamic contrast enhancement and combined model
Authors: Dang Haodan , Chen Yu , Zhang Zhuhua , Shi Xiaohua , Chen Xingming , Zhu Xiaoli , Hou Bo , Xing Haiqun , Xue Huadan , Jin Zhengyu 
Published: March 2020

Objectives:This study was designed to investigate the distribution of the independent parameters of PET and MR in tumour differentiation and staging and to evaluate the diagnostic efficiency of the independent parameters and combined model of PET/MR in the tumour differentiation of head and neck squamous cell carcinoma (HNSCC).Methods:The patients with the preliminary diagnosis of HNSCC were included and underwent the integrated PET/MR The parameters included the diffusion-weighted imaging, dynamic contrast enhancement and PET. The correlations between different parameters and the distribution in groups of tumour differentiation and staging were analysed. The combined model was established with complementary PET/MR parameters. The diagnostic efficiency of the independent parameters and combined model in the tumour differentiation were analysed by receiver operating characteristic curve.Results:The correlations between the parameters of dynamic contrast enhancement and PET were most significant. There were significant differences between the well-differentiated group and the moderately/poorly differentiated group in terms of the mean values of apparent diffusion coefficient (ADC) and standardised uptake value (SUV) (p < 0.05). The distributions among different tumour stage groups were not statistically different in all the parameters. The diagnostic efficiency of tumour differentiation increased in the order of Kepmean, SUVmean, ADCmean, and the combined model.Conclusions:Compared with the independent parameter, the combination of multiple parameters with PET/MR can further improve the diagnostic performance of tumour differentiation in HNSCC.
The iCRF Generator: Generating interoperable electronic case report forms using online codebooks
Authors: de Ridder Sander , Beliën Jeroen A.M. 
Published: March 2020

Semantic interoperability of clinical data is essential to preserve its meaning and intent when the data is exchanged, re-used or integrated with other data. Achieving semantic operability requires the use of a communication standard, such as HL7, as well as (functional) information standards. Manually mapping clinical data to a medical thesaurus, such as SNOMED CT, is complicated and requires expert knowledge of both the dataset, including its context, and the thesaurus. As an alternative, the (re-)use of codebooks, data definitions which may already have been mapped to a thesaurus, can be a viable approach. We’ve developed the iCRF Generator, a Java program that can generate the core of an interoperable electronic case report form (iCRF) for several of the major electronic data capture systems (EDCs). To build their CRFs, users can select one or more items from established codebooks, available from an online system called ART-DECOR. By providing an easy to use method to create CRFs for multiple EDCs based on the same codebooks, interoperability can be more easily attained.
Hubungan Postur Kerja dan Getaran Mekanis dengan Keluhan Musculoskeletal Disorder Pekerja PT. BMSTI
Authors: Sari Yulia , Ningrum Perdani , Qadrijati Isna 
Published: March 2020

Background: one of the problems related to the health of workers is musculoskeletal disorder. Risk factors for musculoskeletal disorders include occupational posture and mechanical vibration. This study investigates the relationship between musculoskeletal disorder complaints with work posture and mechanical vibration. Method: The study aims to determine the relationship between work posture and the incidence of musculoskeletal disorders. This research is an observational analysis with cross-section approaches, samples of this research using the total working population of 110 units of spinning workers in the PT Bintang Makmur Sentosa Textile Industry (BMSTI). Data collection techniques with observations and filling questionnaires. Worker posture and mechanical vibration were measured by the REBA assessment method, as well as the occurrence of musculoskeletal disorders (MSDs) complaints measured via the Nordic Body map (NBM) sheet filling. Data was analyzed using the Spearman correlation test. Results: Spearman test correlation suggests that there is a significant link between the musculoskeletal disorder complaints with the work posture p=0.000; r=0.819 and mechanical vibration p=0.000; r=0.951. The influence of work posture and mechanical vibration in the complaint of musculoskeletal disorders as much as 91.8%. Conclusion: there are a significant relationship and influence between work posture and mechanical vibration with the complaint of musculoskeletal disorders.
Contraceptive Method Preference among Conditional Cash Transfer Beneficiaries in Indonesia
Authors: Frenty Nurkhalim Ratna , Susilowati Indah , Jayanti Krisnita Dwi 
Published: March 2020

Background: Conditional Cash Transfer (CCT) or known as Program Keluarga Harapan (PKH) in Indonesia is a potential program to improve health outcomes, especially reproductive health. This program targeted women from the poor as its beneficiaries. The beneficiaries of this program should visit selected the primary health care to have antenatal care as if they are pregnant. Also, they have to do the growth monitoring regularly if they have children under six. Some studies have found that poor people have a higher risk of unmet need compared to the group with better economies. Could this poor group have a high level of unmet need?. Method: A Cross-sectional study of 172 women which all CCT beneficiaries interviewed using a structured questionnaire. We gathered socio-demographic data and the using of contraception from the respondent. The data were analyzed using descriptive method. Results: Contraceptives practice among CCT beneficiaries is relatively high (89.6%) and unmet need for limiting childbirth was 4.1% higher than Indonesia unmet need in 2017. Most respondents preferred using pills and injection than any other method and procured it from primary healthcare centre and local/village midwife for free. Conclusion: Pills and injection method were mostly chosen by the respondent. The total unmet need (for limiting) was slightly lower than Indonesia unmet need in 2012. It seems that these CCT beneficiaries don’t meet an obstacle to access contraception. The unmet need for spacing somehow needs further investigation.
Soft x-ray laser beamline for surface processing and damage studies
Authors: Ishino Masahiko , Dinh Thanh-Hung , Hosaka Yuji , Hasegawa Noboru , Yoshimura Kimio , Yamamoto Hiroki , Hatano Tadashi , Higashiguchi Takeshi , Sakaue Kazuyuki , Ichimaru Satoshi , Hatayama Masatoshi , Sasaki Akira , Washio Masakazu , Nishikino Masaharu , Maekawa Yasunari 
Published: March 2020

We have developed a soft x-ray laser (SXRL) beamline equipped with an intensity monitor dedicated to ablation study such as surface processing and damage formation. The SXRL beam having a wavelength of 13.9 nm, pulse width of 7 ps, and pulse energy of around 200 nJ is generated from Ag plasma mediums using an oscillator-amplifier configuration. The SXRL beam is focused onto the sample surface by the Mo/Si multilayer coated spherical mirror. To get the correct irradiation energy/fluence, an intensity monitor composed of a Mo/Si multilayer beam splitter and an x-ray charge-coupled device camera has been installed in the beamline. The Mo/Si multilayer beam splitter has a large polarization dependence in the reflectivity around the incident angle of 45°. However, by evaluating the relationship between reflectivity and transmittance of the beam splitter appropriately, the irradiation energy onto the sample surface can be derived from the energy acquired by the intensity monitor. This SXRL beamline is available to not only the ablation phenomena but also the performance evaluation of soft x-ray optics and resists.
Morphological and chemical dynamics upon electrochemical cyclic sodiation of electrochromic tungsten oxide coatings extracted by in situ ellipsometry
Authors: Zimmer Alexandre , Gilliot Mickaël , Broch Laurent , Boulanger Clotilde , Stein Nicolas , Horwat David 
Published: March 2020

The sodiation–desodiation process of sputtered amorphous electrochromic tungsten oxide coatings in an aqueous-based medium was simultaneously monitored over 99 cycles by cyclic voltammetry and in situ spectroscopic ellipsometry. This allowed extracting the evolution of optical and geometrical parameters upon cycling. The resulting electrochemical coloring-bleaching process was dynamically fitted in the 1.8–2.8 eV optical range with a four-phase model including a constrained spline parametrization of the dielectric function. This allows real time access to thickness, surface roughness, and dielectric function of

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. The temporal evolution of the latter in the fully colored state was used to highlight the porosity extent of the probed coating of opened morphology. The designed spectroelectrochemical approach was applied to map the temporal evolution of the

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Band-rejection filter with high extinction ratio using prism-waveguide cascaded coupling system
Authors: Ran Maowu , Cai Wenjuan , Zhang Yincong , Wang Xianping , She Yanchao , Yin Cheng , Wu Jian 
Published: March 2020

A band-rejection filter is proposed based on a prism-waveguide cascaded coupling system, which is composed of an equilateral trapezium prism and a deposited multilayer structure. By properly adjusting the thickness of the coupling layer and the light extinction coefficient of the guiding layer, the radiative and intrinsic dampings matching condition could be well satisfied, and then a series of reflectivity dips will appear in the reflectivity wavelength spectrum. Since the module of reflectivity is smaller than one, the extinction ratio of the rejected frequency via the cascaded coupling system is twice as high as that of the single-coupling technology. By narrowing the guiding layer to a micrometer scale, the free spectral range is broad enough to cover the Raman spectrum scattered from the frequently used sample. In addition, the numerically calculated results show that the light in the free spectral range is mostly reflected, with an insertion loss down to 0.45 dB. Compared to previously reported band-rejection filters, it is relatively simple to manufacture our device, which possesses potential applications to help distinguish the Raman signal from the elastic scattering background.
Chirped-pulse generation from optical parametric oscillators with an aperiodic quasi-phase-matching crystal
Authors: Liu Pei , Heng Jiaxing , Zhang Zhaowei 
Published: March 2020

We describe chirped-pulse generation from an optical parametric oscillator using an aperiodic quasi-phase-matching crystal as the gain medium. We examine the pulse formation dynamics, and reveal that the excitation of chirped-pulse oscillation is assisted by the position-dependent conversion-wavelength and the pump-to-signal temporal walk-off along the gain medium. Stable oscillation is confirmed by numerical simulations and experimental demonstrations. In a preliminary experiment, we obtained a signal wave covering 1293–1734 nm and an idler wave covering 2.9–5.0 µm from an oscillator based on a 2-mm-long aperiodically poled

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crystal. These results represent a new, to the best of our knowledge, pulse formation mechanism inside a nonlinear oscillator, which is promising for generating light pulses with very wide instantaneous bandwidth and at arbitrary wavelengths.
Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus
Authors: Lila V. A. 
Published: March 2020

Systemic lupus erythematosus (SLE) is characterized by a variability in clinical manifestations and laboratory abnormalities, which creates objective diagnostic difficulties.Objective: to investigate clinical and laboratory parameters in patients with definite and probable SLE.Patients and methods. The investigation enrolled 94 patients, 38 of whom were diagnosed with probable SLE. All the patients underwent immunological examination and unaffected skin biopsies, followed by an immunohistochemical study, the so-called lupus strip test (LST).Results and discussion. The group of patients with definite SLE showed a direct correlation between positive LST and disease activity (r=0.6), acute skin lesion (r=0.42), and elevated anti-double-stranded DNA antibody concentrations (r=0.37), and their inverse correlation with dry syndrome (r=-0.44). In patients with probable SLE, deposition of immunoreactants in the unaffected skin was detected in almost half of the cases, despite lower disease activity and specific antibody deficiency. Thus, LST that is quite easy to use and interpret its results can be used as an additional criterion for the differential diagnosis of SLE, especially in its early stages.
Bone mineral density in elderly and senile women with knee and hip osteoarthritis
Authors: Averkieva Yu. V. , Grigorieva I. I. , Raskina T. A. 
Published: March 2020

Objective: to study bone mineral density (BMD) in elderly and senile women with knee and hip osteoarthritis (OA).Patients and methods. The investigation enrolled 124 women (mean age, 73.3±8.46 years) diagnosed with OA meeting the ACR diagnostic criteria. Lumbar spine (LI-IV) and femoral neck BMD values were determined; knee and hip X-ray in the frontal projection was carried out to assess the radiographic stage according to the Kellgren and Lawrence classification.Results and discussion. The overall incidence of osteoporosis (OP) and ostopenia in the study cohort was 28 and 41%, respectively. OP was diagnosed in 20% of women aged 60–74 years and in 38% of those aged 75–90 years (p<0.05); osteopenia was in 41 and 42%, respectively (p>0.05). In the age groups of 65–74 years and ≥75 years, women with stage III–IV hip OA had a significantly higher femoral neck BMD than those with Stage I–II (p<0.05). At the same time, the later radiographic stages of hip OA were associated with lower lumbar spine BMD (p<0.05). The patients of both age groups who had Stages III and IV knee OA had a significantly higher lumbar spine BMD than those with Stage I–II OA (p<0.05). The femoral neck BMD in patients with Stages I–II and III–IV knee OA was comparable in both age groups (p>0.05).Conclusion. The relationship between BMD and OA-related structural changes is contradictory and requires further investigation.
Efficacy of rituximab for glandular Sjö gren's disease according to international clinical trials
Authors: Torgashina A. V. 
Published: March 2020

Sjögren's disease (SD) is a chronic autoimmune disease characterized by lymphoplasmacytic infiltration of the exocrine glands, leading to the development of their destruction and progressive functional failure. The prevalence of SD is about 5%, which makes it one of the most common autoimmune diseases. SD often has a chronic, slowly progressing course.The paper discusses the results of international clinical trials of the efficiency of anti-B-cell therapy with rituximab (RTM) for glandular SD. It considers the impact of this therapy on various immunological, histological indicators, subjective and objective parameters of glandular function, and disease activity. Possible reasons for the discrepancy between the results of open-label clinical trials and randomized clinical trials, as well as predictors for the efficiency of RTM therapy are discussed.It has been found that RTM used to treat SD effectively reduces B-cell activity, improves the morphological pattern in the salivary glands and some extraglandular manifestations of the disease, and diminishes dryness and weakness. Anti-B-cell drugs have a great potential to treat SD.
ANXIETY LEVEL AND PARAMETERS OF THE CARDIOVASCULAR SYSTEM IN ATHLETES OF VARIOUS QUALIFICATIONS
Authors: Turbasova N , Bulygin A , Revnivykh I , Karpov N , Elifanov A 
Published: March 2020

Aim. The purpose of the study is to establish the level of anxiety and indicators of the cardio-vascular system in athletes of various qualifications. Materials and methods. The study involved 241 athletes aged 14-30 years of various qualifications and sports. To assess personal and situational anxiety, the Spielberger – Khanin state-trait anxiety inventory was used. The obtained indicators of the cardiovascular system were compared with the reference values. Results. For all athletes of various sports, the moderate type of situational and personal anxiety prevailed. Highly skilled athletes distinguished a group of athletes with high situational and personal anxiety. Arterial hypertension in athletes of cyclic sports and martial arts is more physiological in nature. In athletes of speed-strength and reactive-strength sports, myocardial wall is thickened due to fibrotic changes. Conclusion. A different level and type of sports activity affects differently the indicators of the cardiovascular system. It was revealed that the level of anxiety affects the physical preparation of athletes for the competitive period.
DYNAMICS OF PSYCHOPHYSIOLOGICAL CHARACTERISTICS AND PHYSICAL FITNESS OF THE PHYSICAL EDUCATION FACULTY STUDENTS AT THE PEDAGOGICAL UNIVERSITY
Authors: Katashinskaya L , Gubanova L , Ermakova E , Kadyseva A , Tsalikova I 
Published: March 2020

Aim. The purpose of the article is to compare the change in psychophysiological indicators and physical fitness of students majoring in physical education and life safety at the beginning and end of their studies. Materials and methods. The study followed university students through the first year to the fifth year of study, 28 of them are boys, 14 girls. To assess the psychophysiological indicators, the latent period of simple and complex visual motor responses was measured. Physical fitness was measured with the help of strength indicators, endurance, flexibility and the level of development of coordination abilities. Results. At the end of the experiment, the positive dynamics of physical fitness of students was noted. Students were characterized by an average and above average level of physical fitness. At the beginning of the experiment, boys demonstrated a higher level of development of physical qualities than girls, with the exception of flexi­bility and static endurance. At the beginning of the experiment, girls were below the average level of development of coordination abilities (Romberg test) and strength index. At the end of the experiment, the level of strength among students was above the average and high. The development of endurance, flexibility, and dexterity increased significantly. At the end of the experiment, the indicators of SVMR and CVMR among the PE faculty students decreased significantly, which indicated the optimization of activation of the central nervous system. Conclusion. The results obtained during monitoring confirm the effectiveness of educational programs at the physical education faculty, which resulted in the positive dynamics of the psychophysiological characteristics and physical fitness of graduates.
PHYSICAL FATIGUE IN SPORTS
Authors: Kornyakova V , Badtieva V , Balandin M , Ashvits I 
Published: March 2020

Aim. The purpose of the article is to review domestic and foreign literature sources for obtaining the up-to-date data concerning fatigue and overfatigue in athletes and searching the priority markers for the up-to-date diagnosis of these conditions. Results. Currently there is no unified approach to the notion of “fatigue”. Many foreign researchers have attached importance to differentiating fatigue into: fatigue being the result of exceeding functional abilities, which contributes to supercompensation, and non-functional overfatigue leading to a consistent decrease in work performance. At present, the diagnostic criteria for recognizing these conditions have not been determined. It makes difficult to correct physical loads that may result in possible overtraining. The differential tests for fatigue and overtraining diagnostics have not also been deve­loped. The modern diagnostics of athletes’ functional fitness is based on biochemical, physiological, and psychophysiological methods. The subjective self-assessment performed by an athlete has been considered as of great importance. It is impossible to increase physical activity without fatigue so the further investigations to extend understanding of fatigue formation mechanisms have become extremely urgent. It will help to develop new diagnostic and rehabilitation technologies. Conclusion. The increasing intensity of physical loads in professional sports results in fatigue and overfatigue that reduce training effectiveness. The reliable diagnostic criteria and differential tests for the timely recognition of fatigue, overfatigue and overtraining have not been developed yet.
Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD
Authors: Cheng Wenwen , Siedlecki-Wullich Dolores , Català-Solsona Judit , Fábregas Cristina , Fadó Rut , Casals Núria , Solé Montse , Unzeta Mercedes , Saura Carlos A. , Rodríguez-Alvarez José , Miñano-Molina Alfredo J. 
Published: March 2020

AbstractThe number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during long-term potentiation (LTP) and are removed from the membrane during long-term depression (LTD). Dephosphorylation of GluA1 at Ser-845 and enhanced endocytosis are critical events in the modulation of LTD. Moreover, changes in scaffold proteins from the postsynaptic density (PSD) could be also related to AMPAR regulation in LTD. In the present study we analyzed the effect of chemical LTD (cLTD) on A-kinase anchoring protein (AKAP)150 and AMPARs levels in mouse-cultured neurons. We show that cLTD induces AKAP150 protein degradation via proteasome, coinciding with GluA1 dephosphorylation at Ser-845 and endocytosis of GluA1-containing AMPARs. Pharmacological inhibition of proteasome activity, but not phosphatase calcineurin (CaN), reverted cLTD-induced AKAP150 protein degradation. Importantly, AKAP150 silencing induced dephosphorylation of GluA1 Ser-845 and GluA1-AMPARs endocytosis while AKAP150 overexpression blocked cLTD-mediated GluA1-AMPARs endocytosis. Our results provide direct evidence that cLTD-induced AKAP150 degradation by the proteasome contributes to synaptic AMPARs endocytosis.
Revista Latinoamericana de Derechos humanos: 20 years
Authors: Cerdas Agüero Evelyn 
Published: March 2020

The objective of this article is to review 20 years of history of the Revista Latinoamericana de Derechos Humanos from its beginnings as DEHUIDELA in 2009. This is achieved through a descriptive analysis based on information gathered from the reports presented annually to IDELA, from each published journal number and its website. The article proposes that this publication is born as an effort of the Instituto de Estudios Latinoamericanos (Institute of Latin American Studies) (IDELA) to support the Human Rights Program, as well as an opportunity to develop various themes that will stimulate the students of the Institute in their research topics. Starting with a new effort in 2009, the journal takes a step to become an indexed scientific publication whose main focus is the publication of works related to human rights as perceived from various disciplines and approaches. It is concluded that the work input over the years has made the Revista Latinoamericana de Derechos Humanos a quality print and electronic publication that contributes to the dissemination of knowledge of human rights in Latin America from within the public university.