bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Global Push for Circular Economy Projects
Authors: Lindauere Dawson , Martinez Eduardo , Fernández-Casatejada Raquel , Santamaria Carmen 
Published: March 2020

Abstract
Historically, industries and society have used the linear model of economic growth, which is based on "take-make-dispose", however this model is not sustainable in today's world. A Circular Economy (CE) model supports "closing the loop" of products and services, recovering value of ecosystem services, while generating savings and creating value for companies and the society.
In the Oil and Gas (O&G) business, Exploration and Production (E&P) activities take place across the globe. This is a case study on how to incorporate CE concepts across a network of global E&P activities. The aim is to leverage the organization in order to gather and share the best ideas and good practices from across the world in CE related to E&P activities. Our voyage towards the CE model was chartered in a three-axis project: Review of the waste management modelEfficient communication of CE projects across the organizationCircular decommissioning of assets
Offshore assets in the E&P industry need a strategy in the short-term for decommissioning. This paper identifies the main barriers to be overtaken and a proposal of joint industry solutions. Reducing and reusing waste and raw materials is one of the main drivers to achieve a CE model. This fact led us to review our management of waste streams and establish a baseline, which allowed us to understand gaps and to develop an improvement strategy. Lastly, we knew that our Business Units (BUs) and exploration teams were full of innovative, driven professionals with good ideas and projects related to CE, but there was no focus in the Company to capture such ideas and little communication between peers in different countries. We present in this paper our vision to ensure success of a CE E&P Strategy as result of efficient communication.
CE operating model, integrates the CE principles in the current business model to turn challenges into opportunities. Our expectation is to help inspire other companies in the joint global effort to achieve sustainable business development.
Short-term Outcomes of Robotic- versus Laparoscopic-Assisted Total Gastrectomy for Advanced Gastric Cancer: A Propensity Score Matching Study
Authors: Yang Changdong , Shi Yan , Xie Shaohui , Chen Jun , Zhao Yongliang , Qian Feng , Hao Yingxue , Tang Bo , Yu Pei-Wu 
Published: March 2020

Abstract
Background: Few studies have been designed to evaluate the short-term outcomes between robotic-assisted total gastrectomy (RATG) and laparoscopy-assisted total gastrectomy (LATG) for advanced gastric cancer (AGC). The purpose of this study was to assess the short-term outcomes of RATG compared with LATG for AGC. Methods: We retrospectively evaluated 126 and 257 patients who underwent RATG or LATG, respectively. In addition, we performed propensity score matching (PSM) analysis between RATG and LATG for clinicopathological characteristics to reduce bias and compared short-term surgical outcomes. Results: After PSM, the RATG group had a longer mean operation time (291.14±59.18 vs. 270.34±52.22 min, p=0.003), less intraoperative bleeding (154.37±89.68 vs. 183.77±95.39 ml, p=0.004) and more N2 tier RLNs (9.07±5.34 vs. 7.56±4.50, p=0.016) than the LATG group. Additionally, the total RLNs of the RATG group were almost significantly different compared to that of the LATG group (34.90±13.05 vs. 31.91±12.46, p=0.065).Moreover, no significant differences were found between the two groups in terms of the length of incision, proximal resection margin, distal resection margin, residual disease and postoperative hospital stay. There was no significant difference in the overall complication rate between the RATG and LATG groups after PSM (23.8% vs. 28.6%, p=0.390). Grade II complications accounted for most of the complications in the two cohorts after PSM. The conversion rates were 4.55% and 8.54% in the RATG and LATG groups, respectively, with no significant difference (p=0.145), and the ratio of splenectomy were 1.59% and 0.39% (p=0.253). The mortality rates were 0.8% and 0.4% for the RATG and LATG groups, respectively (p=1.000). Conclusion : This study demonstrates that RATG is comparable to LATG in terms of short-term surgical outcomes.
Determinants of early postnatal care attendance: analysis of the 2016 Uganda Demographic and Health Survey
Authors: Ndugga Patricia , Namiyonga Noor Kassim , Sebuwufu Deogratious 
Published: March 2020

Abstract
Background
The first two days after childbirth present the highest risk of dying for a mother. Providing postnatal care within the first two days after childbirth can help avert maternal mortality because it allows early detection of problems that could result in adverse maternal health outcomes. Unfortunately, knowledge of the uptake of early postnatal care (EPNC), which is imperative for informing policies aimed at reducing maternal mortality, remains low in Uganda. Therefore, the purpose of this study is to investigate the determinants of early postnatal care attendance among Ugandan women.
Methods
This study was based on nationally representative data from the 2016 Uganda Demographic and Health Survey. The study sample comprised 5,471 women (age 15–49) who delivered a child in the 2 years preceding the survey. We used logistic regression to identify factors associated with the use of early postnatal care.
Results
Our findings showed that 50% of mothers used EPNC services for their most recent delivery in the 2 years preceding the survey. Women’s residence, education level, religion, wealth status, marital status, occupation, antenatal care attendance, place of delivery, birth order, perceived accessibility of health facilities, and access to mass media messages were associated with greater use of EPNC. The percentage of women receiving EPNC was much higher among women who delivered at a health facility, either a public facility (63%) or private facility (65%), versus only 9% among women who delivered at home. Multivariate analysis showed that delivery at a health facility was the most important determinant of early postnatal care attendance.
Conclusions
To increase mothers’ use of EPNC services and improve maternal survival in Uganda, programs could promote and strengthen health facility delivery and ensure that EPNC services are provided to all women before discharge. Even so, the fact that only about two-thirds of women who delivered at a health facility received early postpartum care shows substantial room for improvement.
Key words Early postnatal care, Uganda, Demographic and Health Survey, place of delivery
Tight versus standard blood pressure control on the incidence of myocardial infarction and stroke: An observational retrospective cohort study in the general ambulatory setting
Authors: Park Bumsoo , Budzynska Katarzyna , Almasri Nada , Islam Sumaiya , Alyas Fanar , Carolan Rachel L. , Abraham Benjamin E. , Castro-Camero Pamela A. , Shreve Maria E. , Rees Della A. , Lamerato Lois 
Published: March 2020

Abstract
Background: The 2017 American College of Cardiology and American Heart Association guideline defined hypertension as blood pressure (BP) ≥ 130/80 mmHg compared to the traditional definition of ≥ 140/90 mmHg. This change raised much controversy. We conducted this study to evaluate incidences of myocardial infarction (MI) and stroke comparing tight (TBPC) and standard BP control (SBPC).

Methods: The data were collected and analyzed in 2018. We retrospectively identified hypertensive patients for 1 year at our institution who were classified by BP rate across 3 years into 2 groups of TBPC (< 130 mmHg) and SBPC (130-139 mmHg). We compared the incidence of new MI and stroke between the 2 groups across a 2-year follow-up. Multivariate analysis was done to identify independent risk factors.

Results: Of 5640 study patients, the TBPC group showed significantly less incidence of stroke compared to the SBPC group. No differences were found in MI incidence between the 2 groups. Multivariate analysis showed that increased age independently increased the incidence of both MI and stroke, and TBPC independently decreased the incidence of stroke but not of MI.

Conclusions: Our observational study suggests that TBPC may be beneficial in less stroke incidence compared to SBPC but it didn’t seem to affect the incidence of MI. Our study is limited by its retrospective design with potential confounders.
Identification of the Eutrema Salsugineum EsMYB90 gene important for anthocyanin biosynthesis
Authors: Qi Yuting , Gu Caihong , Wang Xingjun , Gao Shiqing , Li Changsheng , Zhao Chuanzhi , Li Chuanshun , Ma Changle , Zhang Quan 
Published: March 2020

Abstract
Abstract
Background: Anthocyanins contribute to coloration and antioxidation effects in different plant tissues. MYB transcription factors have been demonstrated to be a key regulator for anthocyanin synthesis in many plants. However, little information was available about the MYB genes in the halophyte species Eutrema salsugineum .
Result: Here we report the identification of an important anthocyanin biosynthesis regulator Es MYB90 from Eutrema salsugineum , which is a halophyte tolerant to multiple abiotic stresses. Our phylogenetic and localization analyses supported that Es MYB90 is an R2R3 type of MYB transcription factor. Ectopic expression of EsMYB90 in tobacco and Arabidopsis enhanced pigmentation and anthocyanin accumulation in various organs. The transcriptome analysis revealed that 42 genes upregulated by Es MYB90 in 35S : EsMYB90 tobacco transgenic plants are required for anthocyanin biosynthesis. Moreover, our qRT-PCR results showed that Es MYB90 promoted expression of early ( PAL , CHS , and CHI ) and late ( DFR , ANS , and UFGT ) anthocyanin biosynthesis genes in stems, leaves, and flowers of 35S : EsMYB90 tobacco transgenic plants.
Conclusions: Our results indicated that Es MYB90 is a MYB transcription factor, which regulates anthocyanin biosynthesis genes to control anthocyanin biosynthesis. Our work provides a new tool to enhance anthocyanin production in various plants.
Keywords : Anthocyanin, flavonoid, Eutrema salsugineum , R2R3 MYB transcription factor, Es MYB90, transcriptional regulation, anthocyanin biosynthesis genes.
Collagen Coating for Tissue Culture
Authors: McNabb Nicole A. , McCullough Shaun D. 
Published: March 2020

Abstract
This protocol is intended for collagen coating of tissue culture dishes and Transwell® multiple well plates. The attached methods document is a formal version of the information included here.Disclaimer: The information presented here has been reviewed and approved for publication by the US Environ do not necessarily represent Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendations for use.
Relationship Between Postoperative Lordosis Distribution Index And Adjacent Segment Disease Following L4-S1 Posterior Lumbar Interbody Fusion
Authors: Zheng Guoquan , Wang Chunguo , Wang Tianhao , Hu Wenhao , Ji Quanbo , Hu Fanqi , Li Jianrui , Chaudhary Surendra K , Song Kai , Song Diyu , Zhang Zhifa , Hao Yongyu , Wang Yao , Li Jing , Zheng Qingyuan , Zhang Xuesong , Wang Yan 
Published: March 2020

Abstract
Background: adjacent segment disease (ASD) is an acknowledged problem of posterior lumbar interbody fusion (PLIF). Many studies have been reported concerning the role of lordosis distribution index (LDI) in spinal biomechanics. However, few reports have been published about the impact of LDI on ASD following L4-S1 PLIF.Methods:The study enrolled 200 subjects who underwent L4-S1 PLIF for degenerative spine disease from 2009 to 2014. The average follow-up term was 84 months. Several lower lumbar parameters were measured, including lower lumbar lordosis (LLL), lumbar lordosis (LL) ,pelvic incidence (PI) and LDI on the pre- and postoperative radiograph. Perioperative information, comorbidities and operative data were documented. Kaplan-Meier curves were plotted for the comparisons of ASD-free survival of 3 different types of postoperative LDI subgroups.Results: The incidence of ASD was found to be 8.5%. LL and LLL increased by 3.96°(38.71° vs 42.67° , P＜0.001) and 3.60° (26.22° vs 28.82° , P＜0.001) after lower lumbar fusion surgery, respectively. Lordosis distribution index (LDI) increased by 0.03 (0.66 vs 0.69, P=0.004) postoperatively. A significant difference(P=0.001) was observed when comparing the incidence of ASD among postoperative LDI subgroups.The Kaplan-Meier curves showed a marked difference in ASD-free survival between low and moderate LDI subgroup (Log Rank test, P=0.0012) , high and moderate LDI subgroup (Log Rank test, P=0.0005)Conclusion: Patients with abnormal postoperative LDI were statistically more likely to develop ASD than those who had normal postoperative LDI. Moreover, patients with low postoperative LDI were at greater risk for developing ASD than those with high postoperative LDI over time.
Genome-wide association analysis of fiber fineness and yield in ramie (Boehmeria nivea) using SLAF-seq
Authors: Huang Kunyong , Shi Yaliang , Zhong Yicheng , Zhu Aiguo , Sun Zhimin , Niu Juan , Chen Jing , Luan M , Chen Jianhua 
Published: March 2020

Abstract
Background Ramie is a major natural fiber crop cultivated in East Asia. The improvement of its fiber yield and fineness are important breeding goals. Fiber yield is a complex quantitative trait comprising ramet number, stem diameter, plant height, skin thickness, and ﬁber percentage. The fiber fineness is a crucial trait for ramie fiber quality. However, there are few association studies for fiber yield traits and fiber fineness on ramie, and lack high-density SNP maps in natural ramie population. Results Here, a panel of 112 core ramie germplasms were genotyped by 215,376 consistent single-nucleotide polymorphisms (SNPs) from specific-locus amplified-fragment sequencing (SLAF-seq), and used for genome-wide association study of fiber fineness and yield. Subsequently, the genetic diversity, linkage disequilibrium (LD), and population structure was conducted based on 215,376 SNPs. Population cluster analysis disclosed five subpopulations. Neighbor-joining (NJ) analysis revealed three major clusters. No obvious relationships were identified between them and their geographic origins. The genome-wide linkage disequilibrium (LD) decayed to r 2 = 0.1 was ~11.75 kb in physical distance. One, seven, one, seven, and twenty-seven significant SNP marker associations were detected for fiber fineness (third season), stem diameter (third season), stem skin thickness (third season), fiber percentage (second season), and fiber percentage (third season), respectively. Two promising candidate genes, whole_GLEAN_10029622 and whole_GLEAN_10029638 resided in the significant trait-SNP association for fiber fineness (third season), which annotated as a cotton fiber-expressed protein and an Arabidopsis thaliana homeobox protein ATH1, respectively and validated by qPCR. Conclusions These results provide information for understanding the population structure, LD decay and genetic variation in ramie natural population. The identified loci or genes for fiber fineness and yield may provide the basis for future research on fiber fineness and yield and marker-assisted selection breeding for ramie.
Neuroprotective and anti-inflammatory effect of Hedyotis corymbosa&nbsp;extract on&nbsp;chronic stress-induced depression model of rat-A in vivo and ex vivo study
Authors: Yun Chen , Zheng Tingting , Zhang Jun , Shi Yu , Peng Jiao , Liu Li , Xiao Haitao , Han Yanni , Chen Keke , Zhang Xue , Chen Yun 
Published: March 2020

Abstract
Background: Depression is a well-known mood disorder characterized by persistently low mood and loss of interest and a feeling of sadness. Plants and plant-derived agents have recently attracted the interest of researchers for their therapeutic effects against several illnesses, including mental disorders, and several herbal plants and herbal formulations are useful against experimental depression. In this study, the neuroprotective effects of Hedyotis corymbosa extract were investigated in rats induced with chronic mild stress.Methods: Animals were designated into the following groups: control, 0, 150, and 300 mg of extracts. The dose was given for 30 consecutive days via the oral route. Sucrose preference analysis, forced swim, and open field tests were performed, and serum cortisol and monoamine levels in brain tissue were determined. Expression of brain-derived neurotrophic factor (BDNF) was also examined.Results: Supplementation with extract increased the sucrose preference ratio, locomotor activity, and monoamines and decreased serum cortisol levels. The protein and mRNA expression of BDNF in the brain tissue was decreased by 62.58% and 73% in control rats. However, supplementation with extracts significantly increased BDNF mRNA expression (by 107% and 229.6% in groups 150 mg and 300 mg, respectively). Similarly, the protein expression of BDNF increased by 82.3% and 141.2% in groups 150 mg and 300 mg, respectively.Conclusion: In summary, experimental results suggest that supplementation with extracts of Hedyotis corymbosa may be effective against depression.
Biomarkers of Sepsis: Time for a Reappraisal
Authors: Pierrakos Charalampos , Velissaris Dimitrios , Bisdorff Max , Marshall John C , Vincent Jean-Louis 
Published: March 2020

Abstract
Introduction: Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers.Methods: Using the same methodology as in our previous review, we searched the PubMed database from 2009 until September 2019 using the terms “Biomarker” AND “Sepsis”. There were no restrictions by age or language and all studies, clinical and experimental, were included.Results: We retrieved a total of 5367 new references since our previous review. We identified 258 biomarkers, 80 of which were new compared to our previous list. The majority of biomarkers have been evaluated in fewer than 5 studies, with 81 (31%) being assessed in just a single study. Apart from studies of C-reactive protein (CRP) or procalcitonin (PCT), only 26 biomarkers have been assessed in clinical studies with more than 300 participants. Forty biomarkers have been compared to PCT and/or C-reactive protein CRP for their diagnostic value; 9 were shown to have a better diagnostic value for sepsis than either or both of these biomarkers. Forty-four biomarkers have been evaluated for a role in answering a specific clinical question rather than for their general diagnostic or prognostic properties in sepsis.Conclusions: The number of biomarkers being identified is still increasing although at a slower rate than in the past. Most of the biomarkers have not been well-studied; in particular the clinical role of these biomarkers needs to be better evaluated.
The Burden of Hyperbilirubinemia in Critically Ill Patients with Hematological Malignancies: Post-hoc Analysis of a Prospective Multicenter Multinational Study
Authors: Bisbal Magali , Darmon Michael , Saillard Colombe , Mallet Vincent , Mouliade Charlotte , Lemiale Virginie , Pene Frederic , Kouatchet Achille , Demoule Alexandre , Vincent Francois , Nyunga Martine , Bruneel Fabrice , Lebert Christine , Renault Anne , Meert Anne-Pascale , Benoit Dominique , Hamidfar Rebecca , Jourdain Merce , Azoulay Elie , Mokart Djamel 
Published: March 2020

Abstract
BackgroundThe evidence on the clinical significance of hyperbilirubinemia (HB) in critically ill patients with hematological malignancies is scarce. We therefore studied its burden in a 2010-2011 Franco-Belgian multicenter prospective study designed to evaluate the prognosis of these patients.Patients and methodsThe cohort comprised 893 patients from 17 centers, 61% men, with a median (interquartile range) age of 60 (49 – 70) years, and preferentially with underlying non-Hodgkin lymphoma (32%) or acute myeloid leukemia (27%). HB was defined as a total serum bilirubin ≥ 33 µmol/L at intensive care unit (ICU) admission. Our main goal was to evaluate the relationship between HB and outcome of critically ill hematological patients. Causes and management of HB in the ICU were analyzed as secondary end points.ResultsHB concerned 185 (21%) patients. Cyclosporine and antimicrobial treatments, ascites and cirrhosis, acute kidney injury, neutropenia, and myeloma (adjusted odd ratio [aOR] 0.38, p=0.006) were risk factors. Hospital mortality was 56.3% and 36.3% in patients with and without HB, respectively (p<0.0001 with the log-rank test). Adjusted for severity of illness, the adjusted odds ratio (95% confidence interval) of HB for in-hospital mortality was 1.86 (1.28, 2.72). HB was overlooked by the ICU team for 92 (53%) patients. Overwise, liver workups for HB led to treatment modifications in 32 (40%) patients, including chemotherapy for cancer progression that was associated with reduced mortality with an adjusted odds ratio of 0.23, (p=0.02).ConclusionHB is associated with outcome of critically ill hematological adult patients and should be systematically explored and treated.
Common variant of NOTCH4 gene modulate functional connectivity of occipital cortex and its relationship with schizotypal traits
Authors: Author) xiaohui xie(Former Corresponding , Zu Meidan , Zhang Long , Bai Tongjian , Wei Ling , Huang Wanling , JI Gong-Jun , Qiu Bensheng , Hu Panpan , Tian Yanghua , Author) Kai Wang(New Corresponding 
Published: March 2020

Abstract
Background Schizotypal traits are considered as heritable traits and the endophenotype for schizophrenia. A common variant in NOTCH4 gene, rs204993, has been linked with schizophrenia, but the neural underpinnings are largely unknown. Methods In present study, we compared the difference of brain function between different genotype of rs204993 and its relationship with schizotypal traits among 402 Chinese Han healthy volunteers. The brain function was evaluated with functional connectivity strength (FCS) using resting-state functional magnetic resonance image (rs-fMRI). The schizotypal traits were measured by the schizotypal personality questionnaire (SPQ). Results Our results suggested that the carriers with AA genotype showed reduced FCS in left occipital cortex than the carriers with AG and GG genotype and the carriers with AG genotype showed reduced FCS in left occipital cortex than the carriers with GG genotype. The FCS values in the left occipital lobe were negatively associated with the SPQ scores and its subscale scores within the carriers with GG genotype, but not within the carriers with AA or AG genotype. Conclusions Our results suggested that the common variant in NOTCH4 gene, rs204993, modulate the function of occipital cortex, which may contribute to the schizotypal traits. These findings provided insight for genetic effect on schizotypal traits and its potential neural substrate.