bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal epidermis collective migration and local Sonic hedgehog signaling promote skeletal branching morphogenesis in zebrafish fins
Authors: Braunstein Joshua A. , Robbins Amy E. , Stewart Scott , Stankunas Kryn 
Published: June 2020

ABSTRACTTeleost fish fins, like all vertebrate limbs, comprise a series of bones laid out in characteristic pattern. Each fin’s distal bony rays typically branch to elaborate skeletal networks providing form and function. Zebrafish caudal fin regeneration studies suggest basal epidermal-expressed Sonic hedgehog (Shh) promotes ray branching by partitioning pools of adjacent pre-osteoblasts. This Shh role is distinct from its famous Zone of Polarizing Activity role establishing paired limb positional information. Therefore, we investigated if and how Shh signaling similarly functions during developmental ray branching of both paired and unpaired fins while resolving cellular dynamics of branching by live imaging. We foundshhais expressed uniquely by basal epidermal cells overlying pre-osteoblast pools at the distal aspect of outgrowing juvenile fins. Lateral splitting of eachshha-expressing epidermal domain followed by the pre-osteoblast pools precedes overt ray branching. We useptch2:Kaedefish and Kaede photoconversion to identify short stretches ofshha+ basal epidermis and juxtaposed pre-osteoblasts as the Shh/Smoothened (Smo) active zone. Basal epidermal distal collective movements continuously replenish eachshha+ domain with individual cells transiently expressing and responding to Shh. In contrast, pre-osteoblasts maintain Shh/Smo activity until differentiating. Smo inhibition using the small molecule BMS-833923 prevents branching in all fins, paired and unpaired, with surprisingly minimal effects on caudal fin initial skeletal patterning, ray outgrowth or bone differentiation. Staggered BMS-833923 addition indicates Shh/Smo signaling acts throughout the branching process. We use live cell tracking to find Shh/Smo restrains the distal movement of basal epidermal cells by apparent ‘tethering’ to pre-osteoblasts. We propose short-range Shh/Smo signaling promotes these heterotypic associations to couple instructive basal epidermal collective movements to pre-osteoblast repositioning as a unique mode of branching morphogenesis.
Early Hemoglobin kinetics in response to ribavirin: Safety lesson learned from Hepatitis C to CoVID-19 therapy
Authors: Rivero-Juarez Antonio , Frias Mario , Machuca Isabel , Gallo Marina , Lopez-Lopez Pedro , Camacho Angela , Rivero Antonio 
Published: June 2020

AbstractBackgroundRibavirin (RBV) is been used for SARS-CoV-2 infection. This drug is associated with a wide range of side effects, mainly anemia, so its use in patients with potential respiratory affectation could not be appropriate. The evidences of adverse events associated with RBV-use has mainly been derived in the context of hepatitis C (HCV) treatment, however the possible use of RBV in CoVID-19 patients could be limited to 14 days.MethodsLongitudinal study including HIV/HCV coinfected patients. We evaluate the hemoglobin dynamics and reductions as well as evaluate the development rate of anemia during the first 2 weeks of therapy in HCV infected patients.Results189 patients were included in the study. The median hemoglobin levels were 14.6 g/dL (IQR: 13.2-15.6 g/dL) and 13.5 g/dL (IQR: 12.3-14.5 g/dL) at weeks 1 and 2 of therapy, respectively. A cumulative number of 27 (14.2%) patients developed anemia (23 grade 1 [12.1%] and 4 grade 2 [2.1%]). We identify a baseline hemoglobin levels of 14 g/dL as the better cut-off to identify those patients with a high chance to develop anemia. Of the 132 patients with baseline hemoglobin level >14 g/dL, 8 developed anemia (6.1%) compared with 19 of 57 (33.3%) with hemoglobin levels lower than 14 g/dL (p < 0.001).ConclusionsOur study shows valuable information about the early hemoglobin kinetic timing in patients on RBV-therapy, that could be useful to tailor CoVID-19 treatment if RBV use is considered.
Group testing: revisiting the ideas
Authors: Skorniakov Viktor , Leipus Remigijus , Juzeliūnas Gediminas , Staliūnas Kęstutis 
Published: June 2020

AbstractThe task of identification of randomly scattered ‘bad’ items in a fixed set of objects is a frequent one, and there are many ways to deal with it. ‘Group testing’ (GT) refers to the testing strategy aiming to effectively replace the inspection of single objects by the inspection of groups spanning more than one object. First announced by Dorfman in 1943, the methodology has underwent vigorous development, and though many related research still takes place, the ground ideas remain the same. In the present paper, we revisit two classical GT algorithms: the Dorfman’s algorithm and the halving algorithm. Our fresh treatment of the latter and expository comparison of the two is devoted to dissemination of GT ideas which are so important in the current COVID-19 induced pandemic situation.
SARS-CoV-2 seroprevalence in the municipality of São Paulo, Brazil, ten weeks after the first reported case
Authors: Tess Beatriz H. , Granato Celso F. H. , Porto Alves Maria Cecília Goi , Pintao Maria Carolina , Rizzatti Edgar , Nunes Marcia C. , Reinach Fernando C. 
Published: June 2020

AbstractA population-based household survey was performed to estimate the prevalence of IgM and IgG to SARS-CoV-2 in residents of six districts in São Paulo City, Brazil. Serum samples collected from 299 randomly-selected adults and 218 cohabitants (N=517) were tested by chemiluminescence immunoassay ten weeks after the first reported case. Weighted overall seroprevalence was 4.7% (95% CI 3.0-6.6%). The low seroprevalence suggests that most of this population could still be infected. Serial serosurveys were initiated aiming to monitor the progress of the ongoing pandemic throughout the entire city. This may help inform public health authority decisions regarding prevention and control strategies.
Managerial perceptions of the strategic relevance of resources and capabilities and its configuration for firm competitiveness: an exploratory study
Authors: Bayon Manoj , Aguilera Pablo 
Published: June 2020

PurposeHighlighting the important role of managerial action in resource orchestration, the purpose of this paper is to explore how differences in managerial perceptions about the strategic relevance of resources and capabilities influences the resource configurations in SMEs from an emerging economy context.Design/methodology/approachUsing a survey-based instrument that was developed by the Global Competitive project (www.gcp.org), the authors identify 62 Mexican SMEs and perform a cluster analysis based on firm size and age and estimate the competitiveness of the SMEs in each cluster.FindingsThe results of our cluster analysis indeed suggest the existence of four configurations of SMEs based on the managerial perceptions of the value creating potential of the different resources and capabilities at the firms' disposal. The authors find evidence that managerial perception of the strategic relevance of resources and capabilities at a firm's disposal could influence firm-level competitiveness. Managers of firms that perceive high value or importance to the resources and capabilities, considered the ten resource pillars for competitiveness in this study, are also likely to be the most competitive.Research limitations/implicationsThis study is exploratory in nature and intends to provide an initial and more descriptive analysis of SME competitiveness in an emerging economy context. Additionality, the study does not take into account the effect of industry membership.Originality/valueThe choice of an emerging economy that are often characterized by asymmetric information and informal rules and regulations provides an original context for an understudied area of research in firm-level competitiveness.
The social progress on the development of global competitiveness
Authors: Carvalho Ícaro Célio Santos de , Di Serio Luiz Carlos , Guimarães Camilla Maria Cavalcante , Furlanetto Karina Santos 
Published: June 2020

Purpose
This study aims to evaluate the competitiveness of nations and seeks to answer the following research question: how does the competitiveness of nations include improvements in the quality of life, thus influencing and contributing to social progress in both social and economic indices?

Design/methodology/approach
This paper collected secondary data from the World Economic Forum and the socioeconomic dimensions of the Social Progress Imperative Index and considered the dimensions of these indices, which were demonstrated using Pearson’s correlation coefficient. The main focus was on the documentary analysis that was carried out to explain the realities of 121 countries from 2014 to 2017 as taken from these indices, considering the 10 countries at the top and bottom.

Findings
This study showed the use of new measures for the performance of nations that are less dependent on economics and focus more on social development, which may be a trend for the future of nations, and produce a more holistic view for the study. “Innovation” is the factor with the weakest relationship with social progress, which is justified by a weaker relationship with one of the subcategories, “basic human needs”, when analyzed in isolation. However, when the authors analyze the best and worst nations, the authors observe that economic factors are still prevalent, with the “institutions” and “infrastructure” factors being effective for improving competitiveness and the quality of life.

Research limitations/implications
The findings represent a new, emerging configuration in country performance, but the study has its limitations, such as the use of only two pooled variables and the fact that it does not correlate their dimensions or variables.

Originality/value
This study can represents an expansion logic for measuring the performance of countries considering social factors. The main contributions of this study are its statistical evidence and documentary analysis of the relationship between economic and social variables. The main contribution of this paper is to show that over time (2014–2017) economic factors, as measured by the competitiveness index of nations, relate to aspects of social welfare, as measured by the social progress index.
From intention to action: an organizational learning case of implementing Building Information Modeling
Authors: Lattuch Frank , Hickey Rebecca Barbara 
Published: June 2020

Purpose
The purpose of this paper is to examine the successful implementation of a digital work method named Building Information Modelling (BIM) and make recommendations to help organizations better test and implement innovative work approaches. Learning experiences not only provide insights into the building sector, but also into any organization interested in culture and effective response mechanisms during technological change.

Design/methodology/approach
By applying a critical incident technique, BIM experts at one mid-sized case organization were interviewed to examine the learning experiences from converting implementation intentions into actions. The information from these interviews was used to formulate a number of practical recommendations.

Findings
The interviews outlined the various development opportunities that implementing new digital methods may offer for senior management and staff. Investing in small projects that work and the corresponding behavioral change required, together with regular project reviews, all help to build unique capabilities and to frame a culture that supports organizational development.

Originality/value
The discussion of the various benefits and conditions under which new technology implementation can improve organizational learning provides practitioners with insights into how effectively to convert change intentions into action.
Application of the MST turbulence model to predict the tip leakage vortex flows
Authors: Wang Chaoyue , Wang Fujun , Ye Changliang , Wang Benhong , Zou Zhichao 
Published: June 2020

Purpose
Tip leakage vortex flow (TLV) is a common flow phenomenon in the axial-flow hydraulic machinery. High-efficiency simulation of TLV is still not an easy task because of the complex turbulent vortex-cavitation interactions. As an important basis of CFD, turbulence model directly affects the efficient computation of TLV. The purpose of this paper is to evaluate the newly developed MST turbulence model in predicting the TLV flows.

Design/methodology/approach
By using the MST turbulence model and the ZGB cavitation model, numerical simulations of the TLV generated by a NACA0009 hydrofoil were performed under the cavitation-free and cavitation conditions, and the results were compared with the available experimental data.

Findings
The important features of TLV are well captured by the MST-based simulation scheme, and the problem of under-predicting the cavitating TLV tube is well solved. Turbulent viscosity is reasonably adjusted in the TLV core regions, and the LES-like mode is activated, which is beneficial to obtain more turbulent information on the same URANS grids. The requirements of grid size and time step of the MST model are much lower than that of the LES method, thereby weighing a good balance between the simulation accuracy and computation cost.

Originality/value
The MST turbulence model is suitable for the high-efficiency simulation of the TLV flows, which can lay a good foundation for efficient engineering computations of the cavitating TLV in the axial-flow hydraulic machinery.
Atomic-scale simulation of hugoniot relations and energy dissipation of polyurea under high-speed shock
Authors: Yao Kaili , Chu Dongyang , Li Ting , Liu Zhanli , Guo Bao-Hua , Xu Jun , Zhuang Zhuo 
Published: June 2020

Purpose
The purpose of this paper is to calculate the Hugoniot relations of polyurea; also to investigate the atomic-scale energy change, the related chain conformation evolution and the hydrogen bond dissociation of polyurea under high-speed shock.

Design/methodology/approach
The atomic-scale simulations are achieved by molecular dynamics (MD). Both non-equilibrium MD and multi-scale shock technique are used to simulate the high-speed shock. The energy dissipation is theoretically derived by the thermodynamic and the Hugoniot relations. The distributions of bond length, angle and dihedral angle are used to characterize the chain conformation evolution. The hydrogen bonds are determined by a geometrical criterion.

Findings
The Hugoniot relations calculated are in good agreement with the experimental data. It is found that under the same impact pressure, polyurea with lower hard segment content has higher energy dissipation during the shock-release process. The primary energy dissipation way is the heat dissipation caused by the increase of kinetic energy. Unlike tensile simulation, the molecular potential increment is mainly divided into the increments of the bond energy, angle energy and dihedral angle energy under shock loading and is mostly stored in the soft segments. The hydrogen bond potential increment only accounts for about 1% of the internal energy increment under high-speed shock.

Originality/value
The simulation results are meaningful for understanding and evaluating the energy dissipation mechanism of polyurea under shock loading, and could provide a reference for material design.
Categorization flexibility and unconventional choices: is life an adventure?
Authors: Chowdhury Tilottama G. , Murshed Feisal 
Published: June 2020

Purpose
This paper proposes that categorization flexibility, operationalized as the cognitive capacity that cross-categorizes products in multiple situational categories across multiple domains, might favorably influence a consumer’s evaluation of unconventional options.

Design/methodology/approach
Experimental research design is used to test the theory. An exploratory study first establishes the effect of categorization flexibility in a non-food domain. Study 1 documents the moderating role of decision domain, showing that the effect works only under low- (vs high-) consequence domain. Studies 2A and 2B further refine the notion by showing that individuals can be primed in a relatively higher categorization flexibility frame of mind. Study 3 demonstrates the interactive effect of categorization flexibility and adventure priming in a high-consequence domain. Study 4 integrates the interactive effects of decisions with low- vs high-consequence, adventure priming and categorization flexibility within a single decision domain of high consequence.

Findings
Consumers with higher- (vs lower-) categorization flexibility tend to opt for unconventional choices when the decision domain entails low consequences, whereas such a result does not hold under decision domain of high consequences. The categorization flexibility effects in case of low-consequence decision domain holds true even when consumers are primed to be categorization flexible. Furthermore, with additional adventure priming, consumers show an increased preference for unconventional options even under a decision domain with high consequence.

Research limitations/implications
This study could not examine real purchase behavior as results are based on cross-sectional, behavioral intention data. In addition, it did not examine the underlying reason for presence of cross-domain categorization flexibility index.

Practical implications
The results suggest that stimuli may be tailored to consumers in ways that increase the salience and the perceived attractiveness of unconventional choices. Further, data reinforce the notion of cross-categorical interrelations among different domains, which could be leveraged by marketers.

Originality/value
This study represents the first documentation of the potential ways by which unconventional product choice might be a function of individuals’ categorization flexibility level across different types of decision domains. The findings yield implications that are novel to both categorization and consumer decision-making literature.
Standards formation and the implications for HRD
Authors: Short Heather , Anderson Valerie Anne 
Published: June 2020

Purpose
The purpose of this study is to explore the implications of national and international standards for human resource development (HRD) practice. It focuses on the experiences, perceptions and learning of those involved in the social construction of standards and standardisation processes.

Design/methodology/approach
The research is grounded in institutional and organisational excellence theories and adopts a qualitative approach based in social constructivism. Thematic analysis of the data obtained from 13 semi-structured interviews leads to a discussion of awareness of standards, standards adoption including constraints, and impact of standards.

Findings
The findings indicate that that there has been a disconnect between the potential impact of British Standards Institute (BSI) HR standards and what has occurred in practice with little awareness of the BSI standards among practitioners.

Research limitations/implications
This paper identifies an absence of institutional isomorphism in the HR arena and highlights the potential for a “standards-practice” gap where HR standards formation processes are perceived as detracting from flexibility and innovativeness in organisational practice.

Originality/value
This study contributes a new perspective of the implications of HR standards formation from the perspective of those involved and further contributes to the wider theorisation of standards in the HRD field.
Unethical sales practices in retail banking
Authors: Tosun Petek 
Published: June 2020

PurposeThis study examines the salesperson-driven unethical behavior toward consumers in the retail banking context.Design/methodology/approachConsumer posts on an online social platform were analyzed using content analysis. Cluster analysis and word association analyses were conducted to analyze the posts across ethics dimensions, customer intentions and banking services.FindingsComplaints about salesperson-driven unethical behavior were classified into three clusters: disrespect, fee deception and other deception. Four themes of consumer intentions emerged from data: expecting an action regarding the staff, fixing the problem, exiting the bank, or just expressing the problem on the social platform. There was a significant difference among clusters in terms of intentions. The deception clusters had a stronger association with fixing the problem, while the disrespect cluster had a stronger association with consumers’ willingness to express their complaints and requests regarding corrective actions for the salespeople.Practical implicationsBanks must differentiate their service recovery approach depending on the problem. While a refund can be more appropriate for recovering deception, a corrective action regarding misbehaving sales staff is expected by the customers for the disrespect problem.Originality/valueThis study contributed to the need for current research on personal selling practices and salesperson ethics in banking services. The unethical sales practices were linked to customer intentions, and several associations were found. An unethical sales behavior framework that can be used in future research was represented.
Digital signage as an opportunity to enhance the mall environment: a moderated mediation model
Authors: Roux Thérèse , Mahlangu Sfiso , Manetje Thembeka 
Published: June 2020

PurposeThere is ample evidence supporting the generalizability of the stimuli-organism-response framework in the retail field, with limited extensions to digital signage inside malls. This article postulates that favourable perceptions of the mall environment result in stronger approach behaviours than positive experienced emotions. This varying indirect effect is predicated to be moderated by shoppers' enjoyment of hedonic digital signage content.Design/methodology/approachThis study was conducted at two upmarket super-regional malls in South Africa with a wide variety of contemporary digital signage displaying hedonic content. Purposive quota sampling was used to intercept and survey 400 regular shoppers viewing dynamic hedonic digital signage content. Data was collected via an interviewer-administered structured questionnaire. Hayes macro conditional process analysis was used to determine the moderating role of hedonic content enjoyment and to estimate regression coefficients of the proposed model.FindingsIt was found that favourable perceptions of the mall environment is strongly associated with approach behaviours relative to the indirect effect of positive experienced emotions. When shoppers' enjoyment of hedonic content is factored in the model, low enjoyment of hedonic content shows an insignificant effect of digital signage on approach behaviours. However, for high enjoyment of hedonic content, this relationship is positive and significant.Research limitations/implicationsDigital signage was only studied as a design cue and the promising role as social cue or ambient factor were thus not take into account. It also applied a cross-sectional survey rather than an experiment and has modelled the effects of digital signage as a part of retail atmospherics rather than its presence or absence in malls. The results were generated based on a survey with shoppers from two upmarket super-regional malls in South Africa while viewing digital signage displaying hedonic content. Findings might differ for utilitarian content and other settings.Practical implicationsPractical recommendations on how shopping mall management could utilise digital signage to possibly increase approach behaviours are provided.Originality/valueThere is very limited research on the effects of digital signage on shoppers in the mall environment. This study is one of the first to consider enjoyment of digital signage content inside malls as moderating variable. Additionally, this study contributed to this growing field of shopper-oriented technologies in methodological and pragmatic manners.