bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of antifungal potential of different extracts of Zingiber officinale against Microsporum gypseum
Authors: Sudan Puneet , Goswami Manish , Singh Jitender 
Published: April 2020

Ginger (Zingiber officinale) has been utilized since ancient times in various traditional systems of medicine like Ayurveda, Unani, and naturopathy because of antifungal and antimicrobial potential against diverse fungal and microbial infections. Moreover, in the Asian subcontinent like India, Pakistan, Bangladesh, etc., ginger is used in many food preparations as a condiment and boiled decoction to treat cold-cough and indigestion. The present research was conducted to find out the antifungal potential of various extracts of dried ginger powder, by means of paper disc diffusion method, with petroleum ether, ethyl acetate, ethanol and aqueous solvents in 25 μml,50 μml and 100 μml concentrations against Microsporum gypseum. Clotrimazole was used as a standard. The present study revealed that ginger is a potent antifungal agent against Microsporum gypseum. The ethanol extract of ginger using 100 μml concentrations depicted the highest zone of inhibition of 19.840+ 0.65mm and 46.139% of mycelial inhibition against the tested pathogen. While other drug extracts in different solvents also revealed reasonable to least antifungal potential. This finding tells us that ginger extracts tested proved to be a potent antifungal agent against Microsporum gypseum.It was found that ethanol extract of ginger is best effective against tested strain. This exploration of ginger extracts has confirmed its importance, particularly in the area of influence on dermatophytic fungal strain.
Prevalence of Vitamin D Deficiency in Primary School Children with Developmental Coordination Disorder (DCD)
Authors: U Ganapathy Sankar , R Monisha , Vallaba Doss Christopher Amalraj , R M Palanivel 
Published: April 2020

The majority of mothers and caregivers of children with DCD were not aware of vitamin D deficiency and its relations to cardiovascular abnormalities and many other non-skeletal abnormalities. It is well known that skeletal muscle integrity and metabolism are boosted by sunray vitamin and Young women’s and children were the victims of vitamin D deficiency. Vitamin D oral supplementation is under routine practice in a western country. However, it has been frequently documented in studies, but there are limited data on the prevalence of Vitamin D deficiency among children with DCD in the Indian population. The study aims to find out the prevalence of vitamin D deficiency in children with DCD in primary schools.20 children with DCDunderwent physical examination on the blood test and physical activity assessments.(50%) were vitamin D deficient (serum 25OHD level), of whom 4% were severely vitamin D deficient and physical activity were significant independent predictors of hypovitaminosis D. Indian mothers of children with DCD were having poor perception regarding their child's green land play and they constrain the children's towards academic activities. Thus they were at higher risk of osteoporosis and osteopenia as there is a higher prevalence of vitamin D deficiency encountered in children with DCD.
Analysis of Land Uses In Iraqi Cities
Authors: Nabil T. Ismael  , Areej Muhy Abdulwahab  
Published: April 2020

Abstract—Land use plans in Iraqi cities are traditional and don’t seek to be sustainable and therefore could have negative impacts on the city from the environmental, economic, social and urban aspects. Consequently, the research aims to analyze the current and future of the land use for a set of Iraqi cities to reach the indicators of the gap between traditional and sustainable plans when planning for land uses.
The research conclusion is that most Iraqi cities are highly urban sprawl, both in reality and in the future expansion of the city. That is because it consumes a lot of agricultural land, cities with low population densities that are unsustainable, and most land uses are unsustainable focusing on reducing the agricultural and green lands in the city and increase residential uses (single type with very low density), and expand the areas of the streets that depend on the automated transportation more than sustainable transportation.
The research suggests that sustainable land uses in Iraqi cities should be as follows:
 Residential use: vertical housing pattern 30 %, horizontal housing pattern 15 %.
 Mixed use 12 %.
 Green, open and recreational areas 22 %.
 Sustainable transport 13 %.
 Public, community and government services 8 %.
PUBLIC-PRIVATE PARTNERSHIP TOWARD THE DEVELOPMENT OF UNIVERSITY CLINICS
Authors: Chopchik V.D. 
Published: April 2020

The article summarizes the main shortcomings in the functioning of university clinics, including inadequate material and technical equipment, the lack of up-to-date diagnostic and treatment technologies, low salary for medical personnel and scientific staff, students’ insufficient practical training. All these issues necessitate the search for more effective forms of establishing university clinics, and, in particular, on the principles of public-private partnership (PPP).
It has been shown that one of the possible ways to develop university clinics is implementing private-public partnership (PPP) that can provide a number of advantages compared with purely public administration: private investment, development of innovative areas, ensuring economic stability, the influx of highly qualified personnel, providing high-quality medical care, ensuring profitability for enterprises etc.
The article provides the methodological approaches to elaborating the model of PPP establishing based on PPP principles. Within the methodological approaches, the key stages of the establishment and development of university clinics and their management have been identified. These stages enable to monitor the implementation of the strategies for developing university clinics and to make adjustments it in accordance with environmental conditions.
The methodological approaches presented in the article are summed up as a set of methods for investigating the possibilities and prospects of improving public and private business to solve a difficult practical task – to organize a modern university dental clinic based on PPP principles. The methodology of creating this model is an important prerequisite for organizing the model and serves as the basis for forming a modern management company, a legally independent high-technology clinical dental base of the university, and system of professional personnel training.
CHARACTERISTICS CHANGES IN PRO-OXIDANT-ANTIOXIDANT STATUS IN PATIENTS WITH ACUTE LEUKEMIA DURING CHEMOTHERAPY
Authors: Maslova H.S. , Skrypnyk I.M. , Hopko O.F. 
Published: April 2020

Changes in the processes of lipid peroxidation and antioxidant system activity are involved in the pathogenesis of carcinogenesis and can affect tumor resistance to chemotherapy. The aim of this study to investigate the nature of changes in pro-oxidant-antioxidant status in patients with acute leukemia during remission induction chemotherapy. Materials and methods. The study involved 42 patients with newly diagnosed acute leukemia, 22 of them were diagnosed to have acute myeloid leukemia and 20 patients had acute lymphoblastic leukemia. The age range was 18-58 years, there were 19 women (45.2%) and 23 men (54.8%). The patients were divided into two groups: I (n=22) included patients with acute myeloid leukemia, who had chemotherapy modes "7+3" and "5+2" for variants M0-2 and "7+3+etoposide" or "5+2+etoposide" for M4-5 variants; II (n=20) group included patients with acute lymphoblastic leukemia, who received chemotherapy according to D. Hoelzer protocol. Hemogram parameters (red blood cells, hemoglobin, white blood cells, platelets) were evaluated at baseline and on the 28th day of chemotherapy. The concentration of thiobarbituric acid reactive substances and catalase activity in the blood serum were assessed as well. Examination of acute myeloid leukemia patients was performed before the chemotherapy, on the 4th and 28th days since chemotherapy started; acute lymphoblastic leukemia patients were examined before chemotherapy, on the 23rd and 28th days. The group of healthy individuals consisted of 20 persons, including 9 (45%) women and 11 (55%) men, aged 22-26 years. Results. The detailed clinical picture of acute leukemia was accompanied by typical changes in hemogram in the patients of both test groups, and namely, by the development of leukocytosis, anemia, thrombocytopenia. At the same time, the patients with acute myeloid leukemia and acute lymphoblastic leukemia demonstrated an increased concentration of thiobarbituric acid reactive substances in 1.8 and 1.89 times, respectively (p<0.05) that was accompanied by an increased serum catalase activity in 1.96 and 1.8 times, respectively (p<0.05) compared to healthy individuals. During "7+3" chemotherapy, acute myeloid leukemia patients were found to show thiobarbituric acid reactive substances increased in 1.9 times on the 4th day of treatment and decreased on the 28th day.The patients with acute lymphoblastic leukemia managed according to the D. Hoelzer protocol demonstrated an increased concentration of thiobarbituric acid reactive substances in the blood serum in 1.33 times on the 23rd day of treatment (p<0.05), maintaining this level up to the 28th day. The catalase activity in the patients of the comparison groups did not change. Conclusion. The debut of acute leukemia is accompanied by activation of lipid peroxidation and antioxidant system enzymes. Сhemotherapy promotes the shift of the prooxidant-antioxidant equilibrium towards the lipid peroxidation activation.
STUDY OF ENDOTHELIOPROTECTIVE ACTION OF COMBINED MEDICINE UNDER ALCOHOLIC CARDIOMYOPATHY
Authors: Suprun E.V. , Tereshchenko M.S. 
Published: April 2020

At present, due to spreading of alcoholic cardiomyopathy among the able-bodied population of industrialized countries, there is an urgent need to search for new medicines possessing a strictly targeted effect, taking into account the complex mechanisms of the damaging effects produced by ethyl alcohol on the myocardium. Therefore, the combination of L-arginine and thiotriazolin (developed by “Farmatron” scientific production association) is of great clinical interest. The same is relevant for Mildronate, Mexidol and Thiotriazolin. The aim of this research was to study the endothelioprotective effect of the medicine combining L-arginine with thiotriazoline (4: 1) (Argitril) in comparison with the standard metabolites as Mildronate, Mexidol, and Thiotirazoline on the morphological and functional characteristics of endotheliocytes and ST2 level in modelled cardiomyopathy and alcohol cardiomyopathy. Alcoholic cardiomyopathy was caused by intragastric administration of 20% ethanol solution in a dose of 8 g/kg for 90 days. All animals were divided into 5 groups, 10 animals in each. All the studied substances were administered intraperitoneally for 30 days: the combined medicine (L-arginine 100 mg/ml + thiotriazolin 25 mg/ml (4:1)) - 200 mg/kg (in recalculation for L-arginine); Mildronate (Grindeks, Latvia) - 250 mg/kg; Mexidol (NPK Farmasoft, Russia) - 200 mg/kg, Thiotriazolin (Galichfarm, Ukraine) - 50 mg/kg. The control and intact groups received physiological saline. The following indicators were assessed: endothelial cell nucleus area (μm2); the density of the nuclei of endotheliocytes (as an indicator for the number of cell nuclei per 1 mm2 of myocardial tissue area) and the relative area of endotheliocytes (%), ST2 protein.
The study has shown that on the 30th day after 90 days of the development of alcohol addiction, the animals were found out to have alcoholic cardiomyopathy. A significant decrease, by 32.38%, in the area of the nuclei of endotheliocytes was observed in the animals of the test group, the density of nuclei of the endotheliocytes lowered by 7% and the relative area of the nuclei of the endotheliocytes reduced by 21.89%. An increase in the concentration of ST2 protein was observed in 3.34 times compared with the intact animals that evidences the presence of endothelial dysfunction.
It has been experimentally proved that the combination of L-arginine/thiotriazolin significantly exceeds the reference medicines as Mildronate, Mexidol and Thiotriazolin in terms of endothelioprotective and cardioprotective effects (effect on the area and density of nuclei of endotheliocytes; concentration of ST2 protein).
COMPARISON OF PREVENTIVE ACTION OF ANTIOXIDANTS UNDER PROLONGED EXPOSURE TO AMINE SALT OF 2,4-DICHLOROPHENOXYACETIC ACID
Authors: Tarasenko Y.A. , Tykhonova O.O. , Deynega T.F. , Volkova O.A. 
Published: April 2020

The article describes the study on the effectiveness of remedies possessing antioxidant properties for chemoprevention of the consequences caused by pesticides toxic effects. 2,4-dichlorophenoxyacetic acid derivatives, and namely, amine salt of 2,4-dichlorophenoxyacetic acid are known as one of the most widely distributed compounds in agriculture. The activation of the free radical processes is considered as a universal mechanism of the damage to biological membranes during chronic intoxication by phenoxyacid derivatives. This work is aimed to compare the preventive effect of the synthetic and natural antioxidants under long-term exposure to the 2,4 - dichlorophenoxyacetic acid. The experiment was performed on Wistar male rats, which received synthetic and natural antioxidants against the background of toxicant administration. Long-term effects of the pesticide caused the activation of the processes of free radical lipid peroxidation, reduced antioxidant supply and activity of antioxidant enzymes. The introduction of medicines with antioxidant properties helped to reduce the content of products of free radical processes, to inhibit the drop of body antioxidant supply and to normalize the activity of antioxidant enzymes.
According to the experimental data obtained, the complex of natural antioxidants (tocopherol acetate, ascorbic acid and quercetin) has the most pronounced corrective properties. This enables us to recommend them for chemocorrection of pathological changes resulted from prolonged exposure to pesticides.
INHIBITION OF TRANSCRIPTION FACTORS NF KAPPA B AND AP-1 LIMITS THE PROGRESSION OF OXIDATIVE-NITROSATIVE STRESS IN THE TISSUE OF CEREBRAL HEMISPHERES IN RATS AFTER MODELLED TRAUMATIC BRAIN INJURY
Authors: Yavtushenko I.V. , Kostenko V.O. 
Published: April 2020

The study was aimed as investigating the effects of inhibitors of transcription factors NF kappa B and AP-1 activation on the development of oxidative-nitrosative stress in rat cerebral hemispheres following experimental traumatic brain injury (TBI). The study included 60 white Wistar male rats weighing 180-220 g, divided into 4 groups of 7 animals in each: the 1st group included pseudo-injured animals subjected to the same manipulations (ether anaesthesia, fixation) as the animals in the experimental groups, except for TBI modelling, the 2nd group included the animals exposed to modelled TBI, the 3rd and 4th groups involved the rats who received ammonium pyrolidine dithiocarbamate, the nuclear translocation inhibitor NF kappa B in a dose of 76 mg/kg and the inhibitor AP-1 SR 11302 in a dose of 1 mg/kg, respectively for 7 days following the TBI modelling. On the 7th day after the simulation of a moderate TBI in rat cerebral hemisphere tissue, the following signs of oxidative-nitrosative stress have been detected: increased production of superoxide radical anion by NADPH and NADH-dependent electron transport chains, increased activity of nitric oxide synthase (total and inducible), a decrease and impairment of the coupling of its constitutive isoform, growth in the concentration of peroxynitrite, the development of decompensated lipid peroxidation. The application of transcription factor inhibitors NF kappa B (PDTC) and AP-1 (SR 11302) significantly reduces the signs of oxidative-nitrosative stress in the tissue of rat cerebral hemispheres on the 7th day of the experiment, reduces the production of superoxide anion radical and the activity of nitric oxide synthase (total and inducible), improves the coupling of its constitutive isoform, limits the peroxynitrite concentration, and enhances the antioxidant potential.
KUALITAS BIODIESEL DARI MINYAK JELANTAH BERDASARKAN PROSES SAPONIFIKASI DAN TANPA SAPONIFIKASI
Authors: Permana Edwin , Naswir M 
Published: April 2020

Biodiesel is an alternative fuel that can be renewed and as a promising of diesel fuel in the future. In this study, the production of biodiesel from used waste vegetable oil through the initial treatment reaction saponification and without saponification. The process of producing of biodiesel can used by the transesterification method. The yield of biodiesel were obtained then analysis for quantity by calculating of the percent yield on each yield for biodiesel with saponification successively is 61.68%. The biodiesel product without saponification successively is 81.93%. The quality test produced for biodiesel density test with and without saponification is 0.8871 g / mL and 0.8975 g / mL ,% FFA 0.3375 mg KOH / g and 0.6325 mg KOH / g, and flash point 184 ℃ and 182.6 ℃.
Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital
Authors: Ali Zafar , Mudassir Ghazala , Nazir Imran , Mamoon Nadira 
Published: April 2020

Objective: Endoscopic duodenal biopsies constitute a significant load of specimens in the histopathological section of a tertiary care hospital. Most of these diseases comprise non-neoplastic lesions causing significant morbidity. The purpose of this study was to see the frequency of these diseases in our patient population and to compare and analyze our results with similar other studies.
Methods: In this retrospective study records of all duodenal biopsies reported from Feb 2017- Jan 2018 were retrieved. Both non neoplastic and neoplastic conditions along with biopsies with unremarkable findings were included. Various histological parameters like villous blunting, IEL count per 100 enterocytes, crypt hyperplasia, inflammation in lamina propria, and presence of microorganisms, any dysplasia or malignancy were studied. Data was statistically analyzed using SPSS v.23.
Results: A total of 159 duodenal biopsies were included in the study. Normal duodenal morphology was noted in 85 (53.45%) cases while 74 (46.83%) cases revealed abnormal duodenal pathology. There were 46 (28.93%) cases consistent with celiac disease. Twenty eight (17.61%) cases were of other duodenal pathologies of which non-specific duodenitis was most common. There were 22 (13.83%) cases of duodenitis and 2 (1.26%) cases were of duodenal ulcer. One case (0.62%) each was seen of Brunner gland hyperplasia, adenocarcinoma, signet ring carcinoma and one case was of metastatic adenocarcinoma.
Conclusion: In our study we found a significant percentage of 46.83% exhibiting abnormal duodenal pathology. Cases consistent with celiac disease were 28.93% while 13.83% of the cases had duodenitis. The percentage of malignant cases was minimal (1.88%).
The global polio eradication initiative in Pakistan: Lessons learnt and prospects for success
Authors: Naseem Sajida 
Published: April 2020

Poliomyelitis commonly called polio is a highly infectious disease caused by three sero types of polio virus 1, 2 and 3, which attacks the nervous system. The virus is transmitted mostly through feco-oral route, less often it is transmitted through polluted food or water. Since there is no treatment or cure to poliomyelitis, this disease can be prevented only. The World Health Assembly in 1988 set the target to eradicate polio globally by the year 2000 through multiple doses of childhood vaccinations that protect a child for whole life.
The Effect of Rapid Solidification on Microstructure and Corrosion of Advanced Biomaterial Co-Cr-Mo-C Alloy
Authors: Erfanian-NazifToosi Hamid-Reza , Lopez Hugo F. 
Published: April 2020

In this research, the microstructure and corrosion properties of rapidly solidified Co-Cr-Mo-C alloy as an advanced biomaterial alloy were studied. The use of rapid solidification casting method represents significant changes in not only the amount of formed e-HCP phase, which is strongly influenced by rapid solidification, but also in electrochemical behavior and solidified structure. In this research, rapid solidified Co-Cr-Mo-C alloy is studied using OM, SEM, EDS, XRD, and dynamic potentiostate. Co-alloy ingots were melted into an induction furnace filled by argon gas and casted into a V-shape sand and chill copper molds to prepare rapid solidified samples and its properties were measured in different cooling rates. The microstructure examination demonstrating the structure of alloy is mainly consist of columnar dendritic structure with the distribution of carbides within primary and secondary dendrites arms and finer dendritic structure along with modified carbide distribution will be achieved by rapid solidification. This structure will improve alloy’s corrosion behavior and reduces its corrosion rate when it is tested in Ringer’s solution as an electrolyte.
بدائل الحلول الأمنية التي توفرها الشبكة الافتراضية الخاصة VPN أنموذج مقترح لاستخدام بدائل سيسكو ومايكروسوفت الامنية في مصرف الرشيد/ مكتب المندوب العام /المنطقة الشمالية
Authors: الدباغ رائد عبد القادر , زينل بشرى علي 
Published: April 2020

يسعى البحث الى توفير أنموذج مقترح لتطبيق الشبكة الافتراضية الخاصة بوصفها الاداة التي يتم بواسطتها حماية المعلومات المنقولة عبر نظام المعلومات المستند على الويب، وقد تضمن تصميم البحث استخدام منهج دراسة الحالة لغرض جمع البيانات عن مجال التطبيق (مصرف الرشيد) وتم استخدام برنامج visio لغرض تصميم ورسم مخططات النماذج المقترحة المستخدمة، اذ تم الاعتماد على البيانات التي تم جمعها من المقابلات الشخصية مع مسؤولي المصرف لغرض ايجاد حلول لمشكلة البحث ، ويعد البحث من انواع البحوث التطبيقية التي تستخدم اسلوب نمذجة البيانات modulation لغرض ايجاد حلول لمشكلة البحث.
وتكمن اهمية البحث في تناولها لاحد المواضيع الحيوية في الوقت الحالي، ألا وهي كيفية جعل البيانات المنقولة عبر انظمة المعلومات تتمتع بالامان، وتوفير وسائل الحماية والامان للمعلومات المنقولة من المركز الى الاطراف وبالعكس.
ولكي يتم تحقيق اهداف البحث بناء انموذج المقترح بأستخدام الشبكة الافتراضية الخاصة من خلال استخدام نماذج لاكثر الشركات ريادةً في مجال تكنولوجيا المعلومات والتي تتمثل بـ Cisco و Microsoft، وخرج البحث بجملة من الاستنتاجات اهمها انه يمكن اعتماد أحد النماذج المقترحة لاستخدام الشبكة الافتراضية الخاصة سواء كان النموذج المقدم من قبل سيسكو او من خلال تطبيق النموذج المقدم من قبل مايكروسوفت.
وعلى ضوء الاستنتاجات أُختُتم البحث بمجموعة من المقترحات اهمها، الأخذ بنموذج مايكروسوفت للشبكة الافتراضية الخاصة نظراً لسهولة تطبيقه باستخدام البنية التحتية للمصرف اذ لايحتاج الى معدات خاصة.
أستخدام نموذج فضاء الحالة SSM في التنبؤ بأسعار المنازل في بغداد
Authors: Majeed Rajaa Kamil 
Published: April 2020

يعد شراء المنزل والحصول على سكن من اهم متطلبات حياة الفرد واستقرار معيشته وان التطور الحاصل في اسعار المنازل بصورة عامة و في بغداد بصورة خاصة متأثراً بعدة عوامل أساسية تشمل مساحة المنزل , عمر المنزل ، الحي الذي يتم السكن فيه وما تتوفر فيه من خدمات اساسية , اذ تم استخدام النموذج الإحصائي نموذج فضاء الحالة SSM لنمذجة أسعار المنازل في مدة زمنية تمتد من عام 2000 ولغاية 2018 والتنبؤ بها حتى عام 2025, واهتم البحث بتعزيز أهمية هذا النموذج ووصفه قياسياً ومقارنته بالنماذج المستخدمة في تحليل السلاسل الزمنية بعد الحصول على السلسلة الزمنية المذكورة انفا لاسعار المنازل خلال عقدين من الزمن في حي المنصور في بغداد الذي تم اختياره لكونه من الاحياء المهمة في العاصمة بغداد وتتوفر فيه الخدمات التي تعد مثالية قياساً ببقية الاحياء المجاورة والتي تقع ضمن محافظة بغداد وتم التوصل الى اختبار امكانية تطبيق نموذج فضاء الحالة SSM في تحليل السلاسل الزمنية و التنبؤ بها وتم اجراء التحليل الاحصائي بأستخدام برنامج E-views version 9 وتطبيق مرشح كالمن في بناء نموذج فضاء الحالة و التنبؤ و التحديث بعد تقدير متغير الحالة في النموذج لتعزيز جودة وكفاءة هذا النوع من النماذج وتمثيله افضل تمثيل للبيانات المدروسة.