bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the size of an alien segment carrying leaf rust and stripe rust resistance in wheat
Authors: Khazan Sofia , Minz-Dub Anna , Sela Hanan , Manisterski Jacob , Ben-Yehuda Pnina , Sharon Amir , Millet Eitan 
Published: April 2020

Abstract
Background
Leaf and stripe rusts are two major wheat diseases, causing significant yield losses. The preferred way for protecting wheat from rust pathogens is by introgression of rust resistance traits from wheat-related wild species. To avoid genetic drag due to replacement of large wheat chromosomal segments by the alien chromatin, it is necessary to shorten the alien chromosome segment in primary recombinants.

Results
Here we report on shortening of an alien chromosome segment in wheat that carries leaf and stripe rust resistance from Sharon goatgrass (Aegilops sharonensis). Rust resistant wheat introgression lines were selected and the alien region was mapped using genotyping by sequencing. Single polymorphic nucleotides (SNP) were identified and used to generate diagnostic PCR markers. Shortening of the alien fragment was achieved by induced homoeologous pairing and lines with shortened alien chromosome were identified using the PCR markers. Further reduction of the segment was achieved in tertiary recombinants without losing the rust resistance.

Conclusions
Alien chromatin in wheat with novel rust resistance genes was characterized by SNP markers and shortened by homoeologous recombination to avoid deleterious traits. The resulting wheat lines are resistant to highly virulent races of leaf and stripe rust pathogens and can be used as both resistant wheat in the field and source for gene transfer to other wheat lines/species.
Septicemia, necrotizing fasciitis, and peritonitis due to Vibrio vulnificus treated with early use of polymyxin B hemoperfusion in a patient undergoing CAPD: a case report
Authors: Kim Jae Young , Joo Young Su , Lee Sangmi , Lee Ji Young , Park Jung Tak , Han Seong Hyeok , Yoo Tae-Hyun , Kang Shin-Wook 
Published: April 2020

Abstract
Background
Vibrio vulnificus infection is a rare but fatal foodborne illness. Here, we report a case of Vibrio vulnificus peritonitis followed by severe septicemia in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD) who was treated with hemoperfusion using polymyxin B immobilized fiber.

Case presentation
A 63-year-old man undergoing CAPD was admitted to the emergency room due to general weakness, fever, and abdominal pain with hazy dialysate. Two days before admission, he had eaten raw fish. Initial laboratory tests including peritoneal fluid analysis suggested peritonitis. Despite empirical intraperitoneal antibiotic treatment, his fever did not subside, and multiple vesicles on the extremities newly appeared. The result of initial peritoneal fluid culture and blood cultures reported Vibrio vulnificus as the most likely causative pathogen. Hemoperfusion with polymyxin B immobilized fiber was performed to control gram-negative bacterial septicemia with antibiotics targeting the pathogenic organism. The patient recovered completely and was discharged without complications.

Discussion and conclusion
Suspicion of Vibrio vulnificus infection in susceptible immunocompromised patients is important for early diagnosis and prompt management. Peritonitis should be noted as a clinical manifestation of Vibrio vulnificus infection in CAPD patients, and polymyxin B hemoperfusion along with proper antibiotics could be considered as a treatment option.
Magnesium supplementation and preeclampsia in low-income pregnant women – a randomized double-blind clinical trial
Authors: de Araújo Carla Adriane Leal , de Sousa Oliveira Larissa , de Gusmão Isabela Melo Buarque , Guimarães Angélica , Ribeiro Moranna , Alves João Guilherme Bezerra 
Published: April 2020

Abstract
Background
Preeclampsia is the major cause of maternal morbidity and mortality in developing countries. Magnesium sulfate is considered first-line therapy against eclampsia and magnesium deficiency in pregnancy has been associated with unfavourable perinatal outcomes. However there are doubts if magnesium supplementation during pregnancy can previne preeclampsia especially in population with high nutritional risk. This trial aims to verify the effect of oral magnesium supplmentation on preeclampsia incidence in low income pregnant women.

Methods
This randomized, double-blind, placebo-controlled trial investigated the effect of oral magnesium citrate supplementation for preeclampsia in low-income Brazilian pregnant women, i.e. annual per capita income of US$ 1025 or less. Participants were admitted to the study with gestational age between 12 and 20 weeks. Magnesium serum level was measured pre-randomization and participants with hypermagnesemia were excluded. After randomizationg participants received magnesium citrate capsule (300 mg magnesium citrate) or a daily placebo capsule, until delivery. Intent-to-treat analysis was performed.

Results
A total of 416 pregnant women were screened and 318 enrolled according to the inclusion criteria; 159 for each arm. Twenty-eight pregnant women were lost to follow-up. 55/290 (18.9%) of pregnant women developed preeclampsia; 26/143 (18.1%) in magnesium group and 29/147 (19.7%) in the control group; OR 0.90 (CI 95% 0.48–1.69), p = 0.747. No cases of eclampsia were registered.

Conclusion
Oral magnesium supplementation did not reduce preeclampsia incidence in low-income and low-risk pregnant women.

Trial registration
Registered at ClinicalTrials.gov (Identifier NCT02032186), December 19, 2013.
Dificuldades em se monitorar os parâmetros microbiológicos de uma marca de água mineral no Estado de São Paulo
Authors: Luiz Thays de Souza João , Souza Vládia Cristina Gonçalves de , Koppe Jair Carlos 
Published: April 2020

O monitoramento dos parâmetros microbiológicos de uma empresa de água minera de porte pequeno é uma tarefa simples porque se tem um número pequeno de poços a serem monitorados na sua área de lavra. Quando se tenta monitorar os parâmetros microbiológicos de marcas globais, muitos obstáculos são enfrentados devido à grande quantidade de poços que cada companhia de água mineral costuma ter. Muitos poços de uma mesma marca de água mineral podem estar localizados em diferentes estados brasileiros. Escolheram-se quatro marcas de águas minerais diferentes de provenientes de empresas de mineração de água mineral para serem monitoradas. A primeira empresa teve 8 poços monitorados e para as outras três empresas monitoraram-se três poços, um para cada empresa. Os seguintes parâmetros microbiológicos foram monitorados durante dias e meses: Escherichia Coli, Coliformes Totais e Bactérias Heterotróficas. As estações climáticas e os vários tipos de embalagens foram considerados neste monitoramento. Todas as marcas analisadas foram adquiridas em estabelecimentos comerciais no estado de São Paulo, no Brasil.
RANCANG BANGUN APLIKASI PEMETAAN DAERAH RAWAN KECELAKAAN BERBASIS ANDROID
Authors: Anggraini Novia , Widya Moh. Anshori Aris , Sufaidah Siti 
Published: April 2020

Kecelakaan lalu lintas merupakan masalah yang membutuhkan penanganan serius mengingat besarnya kerugian yang diakibatkannya. Salah satu upaya untuk meningkatkan keselamatan transportasi yaitu dengan mengetahui titik lokasi rawan kecelakaan. Metode yang digunakan untuk mengidentifikasi lokasi rawan kecelakaan yaitu metode Angka kecelakaan dan frekuensi kecelakaan. Tujuan studi ini untuk mengidentifikasi titik lokasi rawan kecelakaan dengan menggunakan metode Batas Angka Ekivalen kecelakaan dan Z-Score. Data kecelakaan lalu lintas yang dianalisis bersumber dari satlantas Jombang dari tahun 2018 dan data yang bersumber dari media elektronik, variabel dummy dari tahun 2016 - 2019. Aplikasi rancang bangun daerah rawan kecelakaan Berbasis mobile, dibangun dengan framework Codeigniter dan Framework 7, MySql sebagai basis data dan Mapbox Api sebagai layanan peta digital. Hasil akhir dari penelitian ini adalah terciptanya aplikasi SIG berbasis mobile yang menyajikan informasi titik lokasi rawan kecelakaan dan tingkat kerawanannya serta notifikasi kepada pengguna jika berada di radius titik rawan yang dapat diakses oleh masyarakat. AbstractTraffic accidents are a problem that requires serious treatment considering the amount of loss caused. One effort to improve transportation safety is to know the location of accident-prone locations. The method used to identify accident prone locations is the accident rate and frequency of accident methods. The purpose of the study is to identify accident prone locations by using the Accidental Equivalent Limit Limits and Z-Score methods. Traffic accident data analyzed were sourced from Jombang Satlantas from 2018 and data were sourced from electronic media, dummy variables from 2016 - 2019. Application of building design for accident-prone areas Based on mobile, built with Codeigniter frame and Framework 7, MySql as database and the Fire Mapbox as a digital map service. The final result of this study is the creation of a mobile-based GIS application that presents information on the location of accident-prone locations and their vulnerability levels as well as notifications to users if they are in a vulnerable point radius that can be accessed by the public.Keywords: Equivalent accident number (EEK); Black Spot; Framework7; SIG; Z-Score
NFE2L2/KEAP1 Mutations Correlate with Higher Tumor Mutational Burden Value/PD-L1 Expression and Potentiate Improved Clinical Outcome with Immunotherapy
Authors: Xu Xian , Yang Yang , Liu Xiaoyan , Cao Na , Zhang Peng , Zhao Songhui , Chen Donglin , Li Li , He Yong , Dong Xiaowei , Wang Kai , Lin Hanqing , Mao Naiquan , Liu Lingxiang 
Published: April 2020

Abstract

Background
Abnormalities in the KEPA1-NRF2 pathway have a role in cancer progression, metastasis, and resistance to chemo- and radiotherapies. Persistent activation of NRF2 associates with poor prognosis across different cancer types. However, the beneficial therapeutic strategy to harness this pathway in cancer remains unclear. This study aimed to investigate the clinical outcome with immunotherapy in NFE2L2/KEAP1 mutant population.

Materials and Methods
We investigated the correlation between NFE2L2/KEAP1 mutations and tumor mutational burden (TMB) and programmed death-ligand 1 (PD-L1) expression status to identify the therapeutic vulnerability. For this purpose, relevance analysis with TMB value was performed in 9,040 patients with cancer, and relevance analysis with PD-L1 expression was performed in 3,457 patients. The Memorial Sloan Kettering Cancer Center (MSKCC) database and real-world evidence were used to assess the immunotherapy response in NFE2L2/KEAP1 mutant subsets.

Results
NFE2L2/KEAP1 mutations occurred in various cancers, and the highest mutation incidences occurred in lung squamous cell carcinoma (LUSC) at 19.16% (NFE2L2) and 10.31% (KEAP1). We confirmed that higher TMB value and PD-L1 expression were associated with NFE2L2/KEAP1 mutations compared with wild-type, especially in non-small lung cancer. MSKCC database analysis showed the improved survival of patients with NFE2L2/KEAP1 mutant with immunotherapy compared with other treatments (median overall survival 22.52 VS 12.89, p = .0034). Real-world evidence further confirmed the efficacy of immunotherapy in the mutant population.

Conclusion
Our study revealed that patients with NFE2L2/KEAP1 mutant could achieve improved outcomes from immunotherapy than the other treatments. These findings may broaden the application of immune checkpoint blockade to patients harboring NFE2L2/KEAP1 mutations.

Implications for Practice
NFE2L2/KEAP1 alterations occur frequently in multiple cancer types and are associated with poor prognosis; however, the efficacious strategy to inhibit this pathway in cancer is poorly understood. This study was designed to analyze the mutational characteristics of NFE2L2/KEAP1 alterations in 9,243 Chinese patients. The highest mutation incidences occurred in lung squamous cell carcinoma at 19.16% (NFE2L2) and 10.31% (KEAP1). Relevance analysis showed the NFE2L2/KEAP1 mutant subsets were associated with higher tumor mutational burden value and programmed death-ligand 1 expression. Clinical data further confirmed NFE2L2/KEAP1 mutations correlate with improved outcome with immunotherapy. These findings suggest the clinical application of immunotherapy in the NFE2L2/KEAP1 mutant population.
KAJIAN EXPERIENTIAL MARKETING DALAM MEMBENTUK CITRA PARIWISATA KOTA BANDUNG
Authors: Prasetyo Mohamad Hadi , Maulani Terra Saptina 
Published: April 2020

Perkembangan perekonomian saat ini sangat pesat, khususnya pada sektor jasa pariwisata. Berbagai daerah di Indonesia berlomba- lomba untuk menjadikan daerahnya menjadi lebih menarik wisatawan. Salah satunya adalah kota Bandung yang merupakan destinasi wisata unggulan provinsi Jawa Barat. Tingginya jumlah kunjungan pada destinasi pariwisata akan memiliki dampak positif terhadap pendapatan daerah. Maka dari itu ketersediaan sarana prasarana pendukung pariwisata menjadi penting untuk meningkatkan kunjungan wisata, sehingga kota Bandung tetap aktraktif dan didukung dengan media promosi yang efektif. Membentuk citra yang positif kepada wisatawan tidak hanya dibentuk dari strategi komunikasi pemasaran, akan tetapi dari berbagai pengalaman yang dirasakan oleh wisatawan. Dengan pengalaman tersebut menentukan apakah wisatawan akan memilih kembali kota Bandung sebagai salah satu tempat destinasi wisata atau tidak. Metode penelitian dalam penelitian ini adalah deskriptif verifikatif, dengan alat pengumpulan data berupa kuisioner. Sampel dalam penelitian ini adalah wisatawan domestik dan asing yang mengunjungi kota Bandung sebanyak 400 orang responden. Hasil dalam penelitian ini menunjukan bahwa terdapat pengaruh Experiential Marketing dalam membentuk citra pariwisata kota Bandung sebesar 86,3% dan sisanya dipengaruhi oleh faktor lain di luar model.
MENINGKATKAN PEMAHAMAN SISWA TERHADAP TUGAS PERKEMBANGAN LANDASAN HIDUP RELIGIUS MELALUI TEKNIK MODELING SIMBOLIS
Authors: Marlina Margaretha Djati 
Published: April 2020

AbstrakPenelitian ini bertujuan untuk mengetahui kemampuan menggunakan dan menerapkan Teknik Modeling Simbolis pada siswa kelas IX.D. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK). Hasil penelitian menujukan, Siklus I dari hasil pengolahan angket, terdapat rata-rata 54.68, ditemukan ada 36 siswa kelas IX.D yang Kurang dan cukup dalam Tugas Perkembangan Landasan Religius, ini berarti menunjukkan hampir 54% siswa, kurang adanya Tugas Perkembangan Landasan Religius masih berdasarkan pujian, mengerjakan karena perintah bukan kesadaran sendiri, melaksanakan ibadah yang wajib saja. Hasil Siklus 2, angket Tugas Perkembangan Landasan Religius Siklus 2, rata-ratanya adalah 86,05 sebanyak 38 orang siswa sudah dapat sangat baik,baik. Hal tersebut berarti terjadi perubahan yang signifikan pada siklus 2 yaitu 100 % tingkat perubahan prilakunya di antaranya dalam Tugas Perkembangan Landasan Religius, adanya Tugas Perkembangan Landasan Religius sudah berdasarkan kedasaran individu, tidak berdasarkan pujian mengerjakan karena perintah menjadi kesadaran sendiri, melaksanakan ibadah ritual tidak hanya yang wajib ditaati yang sunah pun dilakukan. Dengan demikian penggunaan Layanan Informasi secara empiris telah terbukti dapat meningkatkan pemahaman siswa dalam Pembiasaan Tugas Perkembangan Landasan Hidup Religius di kelas IX.D SMPN 34 Bandung tahun Pelajaran 2018/2019. AsbtractThis study aims to determine the ability to use and implement Symbolic Modeling Techniques in class IX.D. The research method used was Classroom Action Research (CAR). The results of the study aimed, Cycle I from the results of questionnaire processing, there were an average of 54.68, found that there were 36 grade IX.D students who were lacking and sufficient in the Task for Development of Religious Platforms, this meant that it showed almost 54% of students, the lack of a Task for Development of Religious Platforms was still based on praise, work because the command is not self-awareness, carrying out compulsory worship only. The results of Cycle 2, questionnaire Development of Religious Platform Cycle 2, the average is 86.05 as many as 38 students have been very good, good. This means that there is a significant change in cycle 2 that is 100% the level of change in behavior including those in the Development of Religious Foundations, the Development of Religious Foundations has been based on individual bases, not based on the praise of working because the order becomes one's own awareness, carrying out ritual worship not only the ones that the Sunnah must also be obeyed. Thus the use of Information Services empirically has been proven to be able to increase students' understanding in the Habit of the Development of Religious Life Platform in class IX.D SMPN 34 Bandung in 2018/2019 Academic year.
RESPON MAHASISWA TERHADAP PEMBELAJARAN BAHASA INGGRIS BERBASIS BLENDED LEARNING MELALUI EDMODO DI UNIVERSITAS BATURAJA
Authors: Agustiani Merie , Ningsih Sulia , Muris Anggraeni Agustin 
Published: April 2020

AbstrakRevolusi Industri 4.0 menjadi kesempatan untuk guru bahasa agar menjadi kreatif dalam mengembangkan kemampuan berbicara siswa. Salah satu usaha kreatif yangg dapat dilakukan adalah menggunakan model pembelajaran blended learning.i Program Studi Teknologi Pendidikan, penggunaan model pembelajaran blendedd learning telah dilakukan di beberapa mata kuliah. Namun untuk mata kuliah bahasa inggris belum pernah dilakukan sebelumnya. Blended learning ini dapat dilakukann dengan berbagai media pembelajaran online, salah satunya adalah edmodo. Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa terhadap pembelajaran bahasa inggris berbasis blended learning melalui edmodo di Universitas Baturaja. Penelitian ini merupakan penelitian deskriptif kuantitatif. Sampel penelitian diambil dengan metode total sampling dengan jumlah 44 orang mahasiswa program studi Teknolologi Pendidikan FKIP Universitas Baturaja tahun akademik 2018/2019. Instrumen dalam penelitian ini menggunakan angket yang dianalisis menggunakan teknik analisis deskriptif. Hasil penelitian menunjukkan bahwa 82% setuju dengan penerapan pembelajaran bahasa inggris berbasis blended learning melalui edmodo dan sisanya 18% tidak setuju pada pembelajaran bahasa inggris berbasis blended learning melalui edmodoAbstractThe Industrial Revolution 4.0 is an opportunity for language teachers to be creative in developing students' speaking skills. One creative effort that can be done is to use a blended learning model. In the Educational Technology Study Program, the use of blended learning models has been carried out in several courses. But for English language course has never been done before. Blended learning can be done with various online learning media, one of which is Edmodo. The Purpose of this research was aimed at finding out the students' responses of English learning based on blended learning through edmodo at Baturaja University. This was a quantitative descriptive study. The sample of the study was taken through total sampling method with a total of 44 students from the Education Technology Education FKIP Baturaja University in academic year 2018/2019. A questionnaire was used to collect the data and it was analyzed using descriptive analysis techniques. The results of this study indicated that 82% of the students agreed with the application of English learning based on blended learning through edmodo, and the remaining 18% did not agree with English learning based on blended learning through edmodo.
Brief: Information Technology as an Aid to Productivity in Petroleum Exploration - Fact or Fiction?
Authors: Dawson Martin , Iliffe James 
Published: April 2020

Summary
This paper considers the relationship between information technology investment, technical productivity, and business benefit. The effect of introducing IT to the industry and its impact on geoscience is described, along with a discussion of whether investment in IT has brought the expected benefits to other industries. The paper concludes with a consideration of the present business perceptions of IT and asks whether a company, by concentrating solely on such issues as technical productivity, will actually maximize the benefits of IT.

Introduction
The upstream petroleum industry has progressively adopted IT since the mid-1950's to aid technical operations. By the late 1980's, nearly all exploration companies had invested heavily in IT. Recently, many companies have begun to scrutinize the costs and benefits of IT more closely. As in other industries, there has been a movement in the petroleum industry to constrain IT expenditures.
A major justification for continued investment in IT has been that the resulting technological change will directly improve business performance through increased productivity. This contention is now being questioned in the more difficult operating conditions of the early 1990's because of a growing belief that IT investment has not produced many of the supposed benefits.

Application of IT in Petroleum Exploration
The deployment of IT in petroleum exploration has had a significant impact on technical practices. The initial applications of IT were in areas like reservoir modeling, seismic processing, and mapping, which required intensive numeric calculations. During the late 1970's and early 1980's, hardware advances (e.g., the appearance of workstations) and software developments (e.g., on-line editors and on-screen graphics) enabled the creation of interactive applications. The possibility of manipulating and interpreting geological data on screen was regarded in many companies as a significant aid to productivity and critical to achieving technical excellence.
How Uncertainty Can Be Managed in a Portfolio Context
Authors: Fleming Peter 
Published: April 2020

Published in Oil & Gas Executive, Volume 2, Number 1, 1999, pages 37-41.

A Strategic Manager's Perspective on Portfolio Management
At BHP Petroleum, we have upgraded our portfolio and organizational capabilities and aligned our internal organization structure to global strategies. We are focusing on growing our business, achieving internationally competitive performance on key drivers, because evidence suggests that efficient growth leads to superior shareholder returns. An important driver of achieving efficient growth is portfolio management. I see strategic management as the iteration between what we consider are possible futures; where we want the company to be positioned within these futures; what kind of performance is required by the shareholders; and, given all these factors, what kind of portfolio can deliver on these sometimes conflicting objectives.

Two Parts of the Model: Uncertainty and Portfolio Management
At BHP, portfolio management started with the need to divest assets that did not fit our strategic or commercial criteria; our initial efforts were on the sell side. These efforts have been successful, with approximately A $1.5billion in assets divested during a period of high prices.
More recently, with the bulk of necessary divestments completed, we have turned our attention to the future and what kind of portfolio we need to deliver our shareholder objectives and how we want to manage uncertainty (i.e., scenarios). We are approaching portfolio management in two ways; first, as a way of thinking and, second, using portfolio-management tools to assist us in making investment choices.
Portfolio management is a way of thinking about the business - moving from where projects are chosen on the basis rates of return to where projects must not only meet hurdle rates, but portfolio fit must also be evident. By portfolio fit, I mean, for example, the balance between short-, medium-, and long-term production and profit growth, consistency with capabilities, overall balance of technical, commercial or country risks, and other such factors. This sounds easy but, in practice, requires a mental shift for decision makers.
Any discussion of portfolio management must deal with the issue of uncertainty. The approach taken to portfolio management in certain and uncertain worlds is fundamentally different. The following are key differences.