bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Disease-Specific Health Related Quality of Life in Women with Anorexia Nervosa
Authors: Winkler Laura Al-Dakhiel , Gudex Claire , Röder Michael Ejnar , Adair Carol E , Sjögren Jan Magnus , Støving René Klinkby 
Published: December 2020

Abstract
Background: Health-related quality of life is severely affected in patients with anorexia nervosa due to both physical and psychological consequences of the disease, but it is still uncertain whether the same factors affect both clinical outcome and quality of life. It is also unknown whether there are differences between patients and controls in terms of self-reported physical, psychological and social well-being. Methods: Women with anorexia nervosa were recruited from specialized eating disorder centers in the five regions of Denmark. Healthy, normal-weight controls were invited via online social media to participate in the study. Six questionnaires including study characteristics, quality of life, eating disorder symptomatology, depression, work and social adjustment and psychological well-being were completed online by all participants. Results: 211 women with anorexia nervosa and 199 controls participated in the study. Women with anorexia nervosa reported significantly lower quality of life, both in terms of disease-specific HRQoL using the Eating Disorders Quality of Life Scale and on measures of general health, psychological well-being, and work functioning. Psychological and cognitive factors were highly associated with poor quality of life (p-value<0.05). Conclusions: Our findings suggest that attention to and management of disordered self-assessment and thought processes may be of special importance to women with anorexia nervosa and their families. It is possible that greater emphasis on such aspects alongside weight gain could enhance patient-clinician alliance and contribute to better treatment outcomes.
The implementation of a smoking cessation and alcohol abstinence intervention for people experiencing homelessness
Authors: Pratt Rebekah , Xiong Serena , Kmiecik Azul , Strobel-Ayres Cathy , Joseph Anne , Everson-Rose Susan A , Luo Xianghua , Cooney Ned , Thomas Janet , Specker Shelia , Okuyemi Kola 
Published: December 2020

Abstract
In the United States, eighty percent of the adult homeless population smokes cigarettes compared to 15 percent of the general population. In 2017 Power to Quit 2 (PTQ2), a randomized clinical trial, was implemented in two urban homeless shelters in the Upper Midwest to address concurrent smoking cessation and alcohol treatment among people experiencing homelessness. A subset of this study population were interviewed to assess their experiences of study intervention. The objective of this study was to use participants’ experiences with the intervention to inform future implementation efforts of combined smoking cessation and alcohol abstinence interventions, guided by the Consolidated Framework for Implementation Research (CFIR). Methods: Qualitative semi-structured interviews were conducted with 40 PTQ2 participants between 2016–2017 and analyzed in 2019. Interviews were audio-recorded, transcribed, and analyzed using a socially constructivist approach to grounded theory. Findings: Participants described the PTQ2 intervention in positive terms. Participants valued the opportunity to obtain both counseling and nicotine-replacement therapy products (intervention characteristics) and described forming a bond with the PTQ2 staff and reliance on them for emotional support and encouragement (characteristics of individuals). However, the culture of alcohol use and cigarette smoking around the shelter environment presented a serious challenge (outer setting). The study setting and the multiple competing needs of participants were reported as the most challenging barriers to implementation (implementation process). Conclusion: The CFIR was useful in offering specific insights about the implementation context of the PTQ2 intervention, including the impact of the factors in the inner and outer settings of the shelter environment. Participants described a discord in their personal goals of reduction compared with the study goals of complete abstinence, which may pose a challenge to the ways in which success is defined for people experiencing homelessness.
Nematode Ashworthius sidemi Schulz, 1933 (Trichostrongylidae: Haemonchinae) in mountain ecosystems – potential risk for the Tatra chamois Rupipacra rupicapra tatrica (Blahout, 1971/1972)
Authors: Nosal Paweł , Kowal Jerzy , Wyrobisz-Papiewska Anna , Chovancová Gabriela 
Published: December 2020

Abstract
Background

Native to Asia highly pathogenic nematode Ashworthius sidemi is now in Europe, and several dozen years after its introduction is a widespread parasite of all wild cervids. For bovids, the nematode is a significant threat to the European bison (Bison bonasus) population and has also been found in mouflon (Ovis aries musimon). This study aimed to assess the risk of infection for the endemic subspecies of northern (Alpine) chamois (Rupicapra rupicapra) – Tatra chamois (R. r. tatrica), having a critically endangered status.
Methods

The study was conducted in mountainous areas of Slovakia and Poland occupied by Tatra chamois (R. r. tatrica), Alpine chamois (R. r. rupicapra), red deer (Cervus elaphus) and roe deer (Capreolus capreolus). Animals (n = 93) shot during licensed hunting and killed in road accidents (roe deer, red deer), or died a natural death (chamois) were post-mortem examined on the presence of Haemonchinae.
Results

A. sidemi affected all of the roe deer, and 90.0% of red deer examined. As regards chamois, it was found in one R. rupicapra originating from the Low Tatras, but not in any pure R. r. tatrica individual living in High and Western Tatras. The present work is the first confirmation of northern chamois infection with this alien, blood-sucking nematode.
Conclusions

Due to an important health hazard related to A. sidemi infection for the Tatra chamois (R. r. tatrica), appropriate measures should be taken to reduce the possibility of parasite transmission between various cervid species living in the Tatra area, as well as the affected population of chamois, and the pure Tatra chamois population existing in the higher parts of the mountains, constituting their natural habitat.
VGG-CovidNet: A Bi-Branched Dilated Convolutional Neural Network for Detection of COVID-19 Cases from Chest X-Ray Images
Authors: Albahar Marwan , Binsawad Muhammed , Binsawad Abdullah 
Published: December 2020

Abstract
Background: The COVID-19 pandemic continues to have a devastating impact on the worldwide population’s health and welfare. A key measure that is taken in combating COVID-19 is eﬀectively screening infected patients. A vital screening process is examination through chest radiology. Initial studies have shown irregularities in the chest radiography images of patients speciﬁc to those suﬀering from the COVID-19 infection. Motivated and inspired by the research community’s open source eﬀorts, this study introduces a dilated bi-branched convoluted neural network (CNN) architecture called VGG-COVIDNet, tailored to detect COVID-19 cases from chest X-ray (CXR) images. Results: The simulation results show that the proposed architecture yielded the highest accuracy and produced the highest sensitivity compared to state-of-the-art architectures. The proposed architecture’s accuracy and sensitivity are 96.5% and 96%, respectively, for each of the infection types. Conclusions: We applied VGG-CovidNet, a VGG-16, and dilated convolution-based bi-branched architecture for classifying diﬀerent types of infectious images into corresponding classes. The front end of the VGG-CovidNet is integrated with the ﬁrst 10 layers of the VGG-16 model. In these layers, the convolution is reduced to two instead of three to alleviate the model’s computation complexity. Furthermore, the back end of the VGG-CovidNet consists of six parallel convolutional layers having diﬀerent strides of convolutional kernel. Using the dilated convolution, we can capture the spatial information of the feature maps and help reduce the complexity of the model.
Preliminary Results of first Belgian Cohort of Juvenile Idiopathic Arthritis: Where Do we Stand in Terms of Quality of Care and Remission?
Authors: La Céline , Lê Phu Quoc , Ferster Alina , Goffin Laurence , Lauwerys Bernard , Durez Patrick , Boulanger Cécile , Maertelaer Viviane De , Sokolova Tatiana , Badot Valérie 
Published: December 2020

Abstract
BackgroundJuvenile idiopathic arthritis (JIA) represents a very heterogeneous disease, and our objectives were to describe the first Belgian cohort of children with JIA, assess their disease characteristics and outcome and identify potential markers of prognosis.MethodsThe CAP48 cohort is a multicentric observational study of children with a recent or well-established diagnosis of JIA (naïve or not to treatment at baseline), evaluated every 6 months during a follow-up of 5 to 10 years.ResultsThere were 125 children included in the cohort, composed of 25 naïve and 100 established patients. The patients had a median age of 6.2 and 4.2 years at onset in the naïve and established cohort respectively, with a predominance of female. All subtypes of JIA were represented in both cohorts. The mean DAS28-CRP and JADAS10-CRP at baseline in naïve patients was 2.52 and 6.0 respectively. Uveitis occurred in 19% of patients and was strongly associated with presence of antinuclear antibodies (odds ratio of 6). Fifty-five percent of naïve patients were in remission at 12 months of follow-up according to the ACR criteria and JADAS10 scores, in contrast with 100% achieving DAS28 remission. ConclusionThis first cohort study in Belgium allowed to compare its data to other existing cohorts and to evaluate quality of care in Belgian French-speaking hospitals. Additionally, it highlighted a superiority of JADAS10 over DAS28 to monitor and evaluate remission in JIA. This study also underlined a need for more accurate markers of prognosis to improve treatment and long-term outcomes.
The Intermediate&nbsp;CD14+CD16+ Monocyte Subpopulation Plays a Role in IVIG Responsiveness of Children with Kawasaki Disease
Authors: Kim Yi Seul , Yang Hyun Jin , Choi Insu , Ha Kisoo , Ki Katrina K , Jeong In Seok , Cho Hwa Jin 
Published: December 2020

Abstract
Background: Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to greater risk for permanent cardiac complications. We aimed to determine the correlation between monocytes and the phenotype of KD in relation to IVIG responsiveness in children. Materials and Methods: The study cohort included 62 patients who were diagnosed with KD, 20 non febrile healthy controls (NFC), and 15 other febrile controls (OFC). In all enrolled patients, blood was taken at least 4 times and laboratory tests were performed. In addition, subtypes of monocytes were characterized via flow cytometry. Results: The numbers of intermediate monocytes were significantly lower in IVIG-resistant group compared to IVIG-responsive group before IVIG infusion (p<0.0001). After infusion, intermediate monocytes decreased in the responsive group, while a trend of increase was observed in the resistant group. Only intermediate monocytes were significant in logistic regression with adjusted OR of 0.001 and p value of 0.03. Conclusions: CD14+CD16+ intermediate monocyte may play an important role in IVIG responsiveness among KD children. Low starting levels of intermediate monocytes, followed by a dramatic increase post-IVIG infusion during acute phase of KD are associated with IVIG-resistance. Functional studies on intermediate monocyte may help to reveal the pathophysiology.
High Antioxidant Activity and Low Toxicity of Gold Nanoparticles Synthesized With Virola Oleífera: An Approach Using Design of Experiments
Authors: Contreras Luis , Ferreira Debora , Keijok Wanderson , Silva Laryssa , Silva André da , Filho Eloi da Silva , Oliveira Jairo , Guimaraes Marco 
Published: December 2020

Abstract
Metallic nanoparticles synthesized by plant extracts and biomolecules represent one of the most promising frontiers in the antioxidants field. Plant compounds apart from act as reducing agents, also allow functionalizing these nanoparticles having multiple applications in different industries. However, the low reproducibility and the difficulty in size, shape and stability control have made it difficult to produce on a large scale. Here we report an optimization process to obtain gold nanoparticles (AuNPs) from green synthesis using a factorial design aiming to present a controlled synthesis using Virola oleifera as a reductant agent. We evaluate the influence of the reaction time, temperature, stirring rate, pH and extract concentration monitoring the Localized surface-plasmon resonance (LSPR) band shift (Δλ). The nanoparticles were characterized using Zeta potential, UV-vis, DLS, TEM, Raman spectroscopy, FTIR and XRD. The as-synthesized AuNPs were stable and homogenous, octahedral, monodisperse, and in shape and size and showed great antioxidant activity determined with ABTS+ and DPPH. Furthermore, these nanoparticles presented low cytotoxicity. Finally, using the factorial design, we were able to develop an optimal path for green gold nanoparticles with high antioxidant activity, low toxicity and good morphological characteristic.
Screening for Macroprolactinemia Is Indispensable for Proper Treatment of Hyperprolactinemia Microadenoma
Authors: DU JING , Li Yanchun , Shen Yuhuan , Yang Wei , Ye Ying , Chen Yongjian 
Published: December 2020

Abstract
BACKGROUND: Macroprolactin microadenoma is a combination of non-functional microadenomas with macroprolactinemia. This study aimed to explore the significance of macroprolactinemia screening for the antidiastole of prolactin microadenoma and macroprolactin microadenoma.METHODS: Retrospective analysis of patients with pituitary microadenoma and screening for macroprolactinemia in patients with hyperprolactinemia was conducted. Based on the prolactin content and screening results, patients were divided into non-functional microadenoma, prolactin microadenoma, and macroprolactin microadenoma groups. The existing forms of prolactin in serum samples were analyzed by gel filtration chromatography and a luminescence immunoassay analyzer. The clinical course of patients and treatment were retrospectively reviewed.RESULTS: The results of gel filtration chromatography confirmed that prolactin in patients with macroprolactin microadenoma was mainly in the form of macromolecules, and the small molecular prolactin was within the normal range. Among 84 patients with hyperprolactin microadenomas, 9 (10.7 %) were diagnosed with macroprolactin microadenoma, and 5 (55.6 %) were treated with bromocriptine. The prolactin content (55.9 ~ 81.0 ng/mL) in the macroprolactin microadenoma group was elevated before the screening and significantly decreased (11.2 ~ 21.2 ng/mL) after screening. The incidence of clinical manifestations was the same as that of the non-functional microadenoma group, but the rate of drug use was higher, which was similar to that of the prolactin microadenoma group.CONCLUSION: Macroprolactinemia screening can effectively identify prolactin microadenomas and macroprolactin microadenomas, which prevent misdiagnosis and mistreatment of macroprolactin microadenomas.
Coronaphobia in Patients With Fibromyalgia.
Authors: Kulekcioglu Sevinc , Akyüz Merve , İnan Özenç , Çetin Alp 
Published: December 2020

Abstract
Background: Throughout the world, the coronavirus disease (COVID-19) pandemic has had a significant effect on human health and daily life. Recent data in literature showed that the COVID-19 pandemic has increased mental health problems. One of these problems, including specific phobia called as “coronaphobia”. The aim of this study was to measure the level of specific phobia created by the COVID-19 pandemic in fibromyalgia (FMS) patients, and to compare this with levels of coronaphobia in patients without FMS.Results: Sixty-one patients participated in the study. Thirty patients diagnosed with fibromyalgia were included in the fibromyalgia group and 31 patients without a diagnosis of fibromyalgia in the control group. The sociodemographic data of all the patients and the presence of chronic disease were determined. All the patients in both groups were instructed to complete the COVID-19 Phobia Scale (C19P-S). The C19PS total score and psychological, psychosomatic, social, and economic subgroups scores were determined to be statistically significantly higher in the FMS group than in the control group (23.2 vs 16.3, 10.9 vs 7.1, 18.4 vs 12.1, and 10.5 vs 6.5 respectively).Conclusion: The results of this study demonstrated that FMS patients have more concerns in this extraordinary global pandemic situation. Early determination of COVID-19 phobia in individuals predisposed to psychological disorders, such as those with FMS, must be kept in mind in respect of providing timely psychological support and being able to keep the disease under control.
Prevalence and Methodological Characteristics of Subgroup Analyses in Stepped Wedge Cluster Randomised Trials: Protocol for a Systematic Review
Authors: Adisso Évèhouénou Lionel , Taljaard Monica , Rivest Louis-Paul , Zomahoun Hervé Tchala Vignon , Durand Pierre Jacob , Légaré France 
Published: December 2020

Abstract
Background: The stepped wedge cluster randomised trial is an increasingly common trial design. The design can be useful for informing real-world clinical decision-making, including decisions about the effectiveness of interventions in particular subgroups. However, there is little existing guidance about how to perform subgroup analyses in the stepped wedge design. We aim to determine the prevalence of subgroup analyses and describe statistical methods used to perform them in stepped wedge cluster randomised trials.Methods: We will conduct a systematic review following the methodology recommended in the Cochrane Handbook for Systematic Reviews of Interventions. We report this protocol according to the PRISMA-P checklist. The protocol has been registered in the Open Science Framework. We will search for terms related to ‘stepped wedge’. Sources will be PubMed, Embase, PsycINFO, Web of Science, CINAHL, Cochrane Library, and Current Controlled Trials Register up to 16 October 2020. Studies will be eligible if they are written in English, involve human participants and are primary or secondary reports of planned or completed stepped wedge cluster randomised trials. Two reviewers will first screen the titles and abstracts, then full texts, to select studies that should be included in the review. Disagreements will be solved by consensus through discussion with a third reviewer. We will extract data related to study characteristics including presence or absence of subgroup analyses, characteristics of subgroup variables examined, statistical methods used to perform subgroup analyses, and adherence to the most consistently recommendations suggested for subgroup analyses in general including in clinical trials. We will perform a qualitative synthesis of the extracted data.Discussion: This protocol offers a reproducible and transparent procedure for a systematic review of the literature. It will provide a portrait of the frequency and types of subgroup analyses performed in stepped wedge cluster randomised trials. These results will inform the development of recommendations for subgroup analyses in such trials.Systematic review registration: This protocol has been registered on Open Science Framework, Registration ID: https://osf.io/2kwrz.
Post-Genotyping Optimization of Dataset Formation Could Affect Genetic Diversity Parameters: An Example of Analyses with Alpine Goat Breeds
Authors: Pogorevc Neža , Simčič Mojca , Khayatzadeh Negar , Soelkner Johann , Berger Beate , Bojkovski Danijela , Zorc Minja , Dovč Peter , Medugorac Ivica , Horvat Simon 
Published: December 2020

Abstract
BackgroundLocal breeds retained unique genetic variability important for adaptive potential especially in light of challenges related to climate change. One objective was to perform, for the first time, a genome-wide diversity characterization using Illumina GoatSNP50 BeadChip of autochthonous Drežnica goat breed from Slovenia, five and one local breeds from neighboring Austria and Italy, respectively. For optimal conservation and breeding programs of endangered local breeds, it is important to detect past admixture events and strive for preservation of purebred representatives of each breed with low or without admixture. In the second objective, we hence investigated the effect of inclusion or exclusion of outliers from datasets on genetic diversity and population structure parameters.ResultsDistinct genetic origin of the Drežnica goat was demonstrated having closest nodes to Austrian and Italian breeds. A phylogenetic study of these breeds with other goat breeds having SNP data available in the DRYAD repository positioned them in the alpine, European and global context. Swiss breeds clustered with cosmopolitan alpine breeds and were closer to French and Spanish breeds. On the other hand, the Drežnica goat, Austrian and Italian breeds were closer to Turkish breeds. Datasets where outliers were excluded affected estimates of genetic diversity parameters within the breed and increased the pairwise genetic distances between most of the breeds. Alpine breeds, including Drežnica, Austrian and Italian goats analyzed here, still exhibit relatively high levels of genetic variability, homogeneous genetic structure and strong geographical partitioning.ConclusionsGenetic diversity analyses revealed that the Slovenian Drežnica goat has a distinct genetic identity and is closely related to the neighboring Austrian and Italian alpine breeds. These results expand our knowledge on phylogeny of goat breeds from easternmost part of the European Alps. The here employed outlier test and datasets optimization approaches provided an objective and statistically powerful tool for removal of admixed outliers. Importance of this test in selecting the representatives of each breed is warranted to obtain more objective diversity parameters and phylogenetic analysis. Such parameters are often the basis of the breeding and management programs and therefore important for preserving genetic variability and uniqueness of local rare breeds.