bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota-based algorithms in the prediction of metachronous adenoma in colorectal cancer patients following surgery
Authors: Liu Yang , Geng Rui , Liu Lujia , Jin Xiangren , Yan Wei , Zhao Lei , Zhao Fuya , Wang Shuang , Guo Xiao , Wei Yunwei 
Published: November 2019

Abstract
Background/Aims:The occurrence of metachronous colorectal cancer (CRC) in patients after surgery has been well documented. Despite high risk, there is a lack of reliable factors or models to be used for predicting the development of metachronous CRC. The objectives of this study were to examine mucosal and fecal microbiota, and to assess their values in the prediction of metachronous colorectal adenoma among CRC patients who underwent surgical removal of their primary CRC. Methods: A cohort of CRC patients was prospectively enrolled, and their mucosal and fecal samples were used for analysis of gut microbiota by sequencing the 16S rRNA genes. The relatively predominant gut microbial populations, in combination with clinical risk factors, were utilized to generate Random-Forest (RF) algorithms for the predication of metachronous adenoma. Results: Patients with metachronous adenoma in the MA group exhibited significantly lower mucosal microbial alpha-diversity compared to those individuals in the nMA group. Linear discriminant analysis of effect size (LEfSe) identified 10 predominant bacterial genera, some of which were identified as independent risk factors for metachronous adenoma. The microbiota-based RF model was established utilizing specific members of predominant gut microbiota and independent clinical risk factors (high body mass index (BMI) and the status of synchronous adenoma) in combination. The RF model had an AUC of 0.885 for predicting metachronous adenoma. The RF model performed well on fecal and off-tumor samples with the AUC of 0.835 and 0.889, respectively. Further, we generated a RF model by including specific bacteria taxa for differential prediction of metachronous adenoma from liver metastasis, which showed good performance with AUC of 0.86. Finally, we introduced a risk score for potential clinical application using the four independent predictive factors, and the scoring system had an AUC of 0.94. The presence of two or more risk factors for metachronous adenoma had a sensitivity and specificity of 90.9% and 89.5%, respectively. Conclusions: The findings have demonstrated that the microbiota-based models and scoring system have good ability to predict the risk for developing metachronous adenoma after surgical resection. The newly established algorithms may hold potential to guide individual postoperative surveillance plan for CRC patients.
Burden of Fatigue among Adults Living with HIV/AIDS Attending Antiretroviral Therapy in EthiopiaBurden of Fatigue among Adults Living with HIV/AIDS Attending Antiretroviral Therapy in Ethiopia
Authors: Gebreyesus Tsiwaye , Belay Addisalem , Berhe Gebretsadik , Haile Gebremedhin 
Published: November 2019

Abstract
Objectives: This study assessed the prevalence and determined factors associated with fatigue among adults living with HIV/AIDS attending antiretroviral therapy at health facilities of Mekelle city, Tigray, North Ethiopia, 2019. Methods: Institution based cross-sectional study design was conducted among 609 HIV/AIDS patients who were selected by using a systematic random sampling method. Data were collected by using interviewer administered structured questionnaire. Level of fatigue was measured by fatigue severity scale. Results: The prevalence of fatigue was found to be 51.7%. The contributing factors that had statistically significant association with fatigue were: having children [AOR= 2.01; 95% CI: 1.09-3.71], CD4 count 200-499 cells/mm3 [AOR= 2.81; 95% CI: 1.58-4.99], having anemia [AOR= 4.90 95% CI: 2.40-9.97], having co-morbid health conditions [AOR= 3.65; 95% CI: 1.71-7.78], showing depression [AOR= 3.68 95% CI: 1.99-6.79], not being physically active [AOR= 3.20 95% CI: 1.50-6.81], clinical stage II and IV [AOR= 3.11; 95% CI: 1.51-6.40] and [AOR= 4.08; 95% CI: 1.37-12.14] respectively. Conclusion: The prevalence of fatigue was medium compared to the global prevalence. Having children, having CD4 count 200-499 cells/mm3, being in clinical stage II/IV, being anemic, having co-morbid health conditions, showing depression, and not being physically active were positively associated with fatigue. Health care stakeholders need to give special attention for HIV patients with the identified associated factors. Keywords: Fatigue, HIV/AIDS, Associated factors, Prevalence, Ethiopia
LncRNA MALAT1 exhibits positive effects on nucleus pulposus cells biology in vivo and in vitro by sponging miR-503 media the P38MAPKs/AP-1 pathway
Authors: Zheng Hongyu , Wang Tingting , Li Xiangmin , He Wei , Gong Zhiqiang , Lou Zhenkai , Wang Bing , Li Xingguo 
Published: November 2019

Abstract
Background: Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulated evidence suggests that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of IDD. In this study, we aimed to investigate the functional effects of lncMALAT1 on NPCs in IDD and the possible mechanism. Results: We validated the decreased expression of MALAT1 in the IDD tissues, associating with increased collagen II and aggrecan expression. In vitro, overexpressed MALAT1 could attenuate the effect of IL-1β on NPCs proliferation, apoptosis, and aggrecan degradation. In vivo, MALAT1 overexpression attenuated the severity of disc degeneration in IDD model rats. Our molecular study further demonstrated that MALAT1 could sponge miR-503, modulate the expression of miR-503, and the activation of downstream MAPK signaling pathways. The effects of MALAT1 on NPCs were partially reversed/ aggregated by miR-503 mimics/inhibitor treatment. Conclusion: Our data suggested that MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for improving IDD.
AKR1B10 accelerates the production of pro-inflammatory cytokines via NF-κB signaling pathway in colon cancer
Authors: Liu Cong , Shi Lei , Li Wanyun , Huang Zilan , Wang Shengyu , Xu Peilan , Li Tingting , Li Zhenyu , Luo Fanghong , Yan Jianghua , Wu Ting 
Published: November 2019

Abstract
Aldo-keto reductase family 1, member B10 (AKR1B10) has been reported to be involved in tumorigenesis of various cancer. In our studies, we evaluated the relationship between AKR1B10 expression and clinicopathological characteristics in colon cancer and showed that AKR1B10 expression was significantly correlated with TNM stage and clinical stage of colon cancer. It has been reported that colorectal cancer is closely associated with chronic inflammation and the underlying molecular mechanisms are still elusive. Here we found that knockdown of AKR1B10 significantly decreased the expression of the inflammatory cytokines, IL1α and IL6, induced by lipopolysaccharide (LPS) via inhibiting NF-κB signaling pathway. Furthermore, AKR1B10 depends on its reductase activity to affect the NF-κB signaling pathway and subsequently affect the production of inflammatory cytokines. In addition, knockdown of AKR1B10 effectively reduced cell proliferation and clonogenic growth, indicating the biologic role of AKR1B10 in colon cancer. Collectively, our findings provided important insights into a previously unrecognized role of AKR1B10 in colon cancer.
A qualitative transcriptional signature for predicting CpG island methylator phenotype status of the right-sided colon cancer
Authors: You Tianyi , Zhao wenyuan , Guo Zheng , Song Kai , Guo Wenbing , Fu Yelin , Wang Kai , Zheng Hailong , Yang Jing , Jin Liangliang , Qi Lishuang 
Published: November 2019

Abstract
Background: A part of colorectal cancer which is characterized by simultaneous numerous hypermethylation CpG islands sites is defined as CpG island methylator phenotype (CIMP) status. Stage II and III CIMP-positive (CIMP+) right-sided colon cancer (RCC) patients have a better prognosis than CIMP-negative (CIMP-) RCC treated with surgery alone. However, there is no gold standard available in defining CIMP status. In this work, we developed a transcriptional qualitative signature to individually predict CIMP status for stage II and III RCC. Results: Based on the relative expression orderings (REOs) of gene pairs, a signature composed of 19 gene pairs was developed to predict the CIMP status of RCC through a feature selection process. A sample is predicted as CIMP+ when the gene expression orderings of at least 12 gene pairs vote for CIMP+; otherwise the CIMP-. The difference of prognosis between the predicted CIMP+ and CIMP- groups was more significantly different than the original CIMP status groups. There were more differential methylation and expression characteristics between the two predicted groups. The hierarchical clustering analysis showed that the signature could perform better for predicting CIMP status of RCC than current methods. Conclusions: The qualitative transcriptional signature for classifying CIMP status at the individualized level can predict outcome and guide therapy for RCC patients.
Ridge‐Furrow Planting System and Wheat Straw Mulching Effects on Dryland Sunflower Yield, Soil Temperature, and Moisture
Authors: Gholamhoseini Majid , Dolatabadian Aria , Habibzadeh Farhad 
Published: November 2019

The current study uses 2‐yr trial data set to investigate the impacts of ridge‐furrow planting system and wheat (Triticum aestivum L.) straw mulching on sunflower (Helianthus annuus L.) yield and some soil parameters. Field experiments were conducted in 2014 and 2015 in two different locations (Tehran and Mashhad Provinces, Iran). The experiments were laid out in a randomized complete block design comprised of four treatments, including control that is, neither ridge‐furrow planting system nor wheat straw mulching (RF0M0); ridge‐furrow planting system without wheat straw mulching (RF1M0); ridge‐furrow planting system with wheat straw mulching only covering 50% of the soil surface (RF1M50); and ridge‐furrow planting system with full covering (100%) of the soil surface with wheat straw mulch (RF1M100). The RF1M0 treatment could not increase sunflower yield, but the application of 50 and 100% wheat straw mulch significantly increased seed yield by10 and 18%, respectively. For both years and sites, on average the maximum seed yield was found with the RF1M100 treatment (1629 kg ha−1), while the minimum value (1318 kg ha−1) was related to RF0M0 treatment. Wheat straw mulching reduced soil temperature and increased soil water storage, organic C and microbial biomass C. We concluded that the ridge‐furrow planting system with full coverage of the soil surface with wheat straw mulch could be critical in the cultivation of sunflower under arid and semiarid areas, where water is the most important factor in determining plant growth and yield.Core Ideas

Ridge‐furrow system promoted sunflower seed yield, applying straw mulch further increased yield.
Improved sunflower yield was explained by optimized water supply and thermal balance.
Wheat straw mulch could reduce risk of heat stress.
Application of wheat straw mulching improved soil biological properties.
The RF1M100 effectively increased soil water storage and biomass accumulation.
Elasticity of single-crystal Fe-enriched diopside at high-pressure conditions: Implications for the origin of upper mantle low-velocity zones
Authors: Fan Dawei , Fu Suyu , Lu Chang , Xu Jingui , Zhang Yanyao , Tkachev Sergey N. , Prakapenka Vitali B. , Lin Jung-Fu 
Published: November 2019

AbstractDiopside is one of the most important end-members of clinopyroxene, which is an abundant mineral in upper-mantle petrologic models. The amount of clinopyroxene in upper-mantle pyrolite can be ∼15 vol%, while pyroxenite can contain as high as ∼60 vol% clinopyroxene. Knowing the elastic properties of the upper-mantle diopside at high pressure-temperature conditions is essential for constraining the chemical composition and interpreting seismic observations of region. Here we have measured the single-crystal elasticity of Fe-enriched diopside (Di80Hd20, Di-diopside, and Hd-hedenbergite; also called Fe-enriched clinopyroxene) at high-pressure conditions up to 18.5 GPa by using in situ Brillouin light-scattering spectroscopy (BLS) and synchrotron X-ray diffraction in a diamond-anvil cell. Our experimental results were used in evaluating the effects of pressure and Fe substitution on the full single-crystal elastic moduli across the Di-Hd solid-solution series to better understand the seismic velocity profiles of the upper mantle. Using the third- or fourth-order Eulerian finite-strain equations of state to model the elasticity data, the derived aggregate adiabatic bulk and shear moduli (KS0, G0) at ambient conditions were determined to be 117(2) and 70(1) GPa, respectively. The first- and second-pressure derivatives of bulk and shear moduli at 300 K were (∂KS/∂P)T = 5.0(2), (∂2KS/∂P2)T = –0.12(4) GPa−1 and (∂G/∂P)T = 1.72(9), (∂2G/∂P2)T = –0.05(2) GPa−1, respectively. A comparison of our results with previous studies on end-member diopside and hedenbergite in the literatures shows systematic linear correlations between the Fe composition and single-crystal elastic moduli. An addition of 20 mol% Fe in diopside increases KS0 by ∼1.7% (∼2 GPa) and reduces G0 by ∼4.1% (∼3 GPa), but has a negligible effect on the pressure derivatives of the bulk and shear moduli within experimental uncertainties. In addition, our modeling results show that substitution of 20 mol% Fe in diopside can reduce VP and VS by ∼1.8% and ∼3.5%, respectively, along both an expected normal mantle geotherm and a representative cold subducted slab geotherm. Furthermore, the modeling results show that the VP and VS profiles of Fe-enriched pyroxenite along the cold subducted slab geotherm are ∼3.2% and ∼2.5% lower than AK135 model at 400 km depth, respectively. Finally, we propose that the presence of Fe-enriched pyroxenite (including Fe-enriched clinopyroxene, Fe-enriched orthopyroxene, and Fe-enriched olivine), can be an effective mechanism to cause low-velocity anomalies in the upper mantle regions atop the 410 km discontinuity at cold subudcted slab conditions.
Experimental determination of the phase relations of Pt and Pd antimonides and bismuthinides in the Fe-Ni-Cu sulfide systems between 1100 and 700 °C
Authors: Helmy Hassan M. , Botcharnikov Roman 
Published: November 2019

Abstract
The stability relations of Pt and Pd antimonides and bismuthinides in the Sb- and Bi-bearing Fe-Ni-Cu sulfide systems have been experimentally determined at temperatures between 1100 and 700 °C in evacuated silica tubes. Both PtSb and PdSb are stable as immiscible liquids at temperatures above 1100 and 1000 °C, respectively. The Fe-Ni-Cu-sulfide melt that coexists with the immiscible antimonide melt can dissolve up to 3.8 wt% Sb at 1100 °C, whereas monosulfide solid solution (mss) dissolves very low amounts of Sb over the entire 1100–700 °C temperature range. The liquidus of Pt-antimonides and Pdantimonides are above 980 and 750 °C, respectively. Bismuth does not form immiscible melt at 1100 °C but may partially partition into a vapor phase at 1050 °C. The Pt- and Pd-bismuthinides crystallize directly from immiscible bismuthinide melt only after crystallization of the sulfide melt into intermediate solid solution (iss). Insizwaite (PtBi2) and froodite (PdBi2) are stable at 780 and 700 °C, respectively. At the last stage of evolution of Sb-bearing magmatic Fe-Ni-Cu sulfide melts, Sb will form immiscible antimonide melt that will extract Pt and Pd from the sulfide melt. During cooling, Pt and Pd-antimonides will crystallize directly from the immiscible antimonide melt, and Pt-phases will form at higher temperatures relative to Pd-phases. Bismuth will partition into vapor phase and concentrate into a low-temperature melt in hydrothermal and porphyry systems that scavenge precious metals. The Sb and Bi (like Te) will be highly incompatible at moderate degrees of mantle partial melting.
An Information Gain-based Method for Evaluating the Classification Power of Features Towards Identifying Enhancers
Authors: Zhang Tianjiao , Wang Rongjie , Jiang Qinghua , Wang Yadong 
Published: November 2019

Background:
Enhancers are cis-regulatory elements that enhance gene expression on
DNA sequences. Since most of enhancers are located far from transcription start sites, it is difficult
to identify them. As other regulatory elements, the regions around enhancers contain a variety of
features, which can help in enhancer recognition.

Objective:
The classification power of features differs significantly, the performances of existing
methods that use one or a few features for identifying enhancer vary greatly. Therefore, evaluating
the classification power of each feature can improve the predictive performance of enhancers.

Methods:
We present an evaluation method based on Information Gain (IG) that captures the
entropy change of enhancer recognition according to features. To validate the performance of our
method, experiments using the Single Feature Prediction Accuracy (SFPA) were conducted on
each feature.

Results:
The average IG values of the sequence feature, transcriptional feature and epigenetic
feature are 0.068, 0.213, and 0.299, respectively. Through SFPA, the average AUC values of the
sequence feature, transcriptional feature and epigenetic feature are 0.534, 0.605, and 0.647,
respectively. The verification results are consistent with our evaluation results.

Conclusion:
This IG-based method can effectively evaluate the classification power of features for
identifying enhancers. Compared with sequence features, epigenetic features are more effective for
recognizing enhancers.
High Gain V-Antenna Array for 60 GHz WiGig Network
Authors: Panda Ribhu Abhusan , Mishra Debasis 
Published: November 2019

Aims:
This paper provides an efficient but simple designed V-Shaped microstrip array
antenna on a RT duroid substrate of dimension 50 mm× 40 mm × 1.6 mm.

Objective:
By considering the ratio of the length of one leg of the V-element and wavelength of
the desired frequency, the angle between two legs of V-Patch has been determined.

Methods:
For a more efficient outcomes, an array design of 4-elements is made and its comparison with
single element is done. A simple line feed technique has been used, with feedline width of 3mm.

Results:
The proposed structure is simulated by using Ansys HFSS software and S-Parameter, antenna
gain, directivity, Standing wave ratio and surface current distribution have been determined.
Unlike conventional patches, the array contains a separation between two consecutive V-Elements
in the shape of a rectangular patch termed as Element Separation Band (ESB) and it plays an important
role in modifying the antenna gain and directivity.

Conclusion:
This antenna produces a return loss of -39.387 dB at 60.58 GHz frequency to cater
the present demand of 60 GHz Wi-Gig and WPAN.
Influence of Light-curing Distances on Microflexural Strength of Two Resin-based Composites
Authors: Al-Zain AO , Marghalani HY 
Published: November 2019

SUMMARY

Objective:
Our objective was to investigate the influence of different curing distances on microflexural strength and the microflexural modulus of two resin-based composites.

Methods:
Two nanohybrid composites were used; Filtek Z250 (Z250) and Tetric EvoCeram (TEC). Rectangular specimens were prepared (2-mm wide × 1-mm deep × 6-mm long) light cured according to the manufacturer's instructions at 0-mm, 2-mm, and 8-mm distances (n=10) and were stored wet at 37°C for 24 hours. A microflexural strength test was performed using a universal testing machine at a crosshead speed of 1 mm/min. The microflexural strength and microflexural modulus data were analyzed using a two-way analysis of variance followed by a Tukey multiple comparison post hoc test (α=0.05).

Results:
The TEC composite had a significantly higher microflexural strength at an 8-mm distance compared with the 0-mm distance. The Z250 composite expressed significantly higher microflexural strength, at 2-mm and 8-mm compared with the 0-mm distance. TEC showed a significantly higher microflexural modulus at an 8-mm distance compared with the 0-mm and 2-mm distances. Z250 also exhibited a significantly higher microflexural modulus at the 2-mm distance, compared with the 8-mm distance. In total, Z250 presented a significantly higher microflexural strength and modulus compared with TEC.

Conclusion:
Curing the explored composites at 2-mm or 8-mm distances from the specimen surface did not have a significant influence on microflexural strength but did significantly affect the microflexural modulus.
PENGARUH KEJELASAN SASARAN ANGGARAN DAN EVALUASI ANGGARAN TERHADAP PENGAWASAN ANGGARAN (STUDI EMPIRIS PADA KABUPATEN KAMPAR)
Authors: Aira Aras 
Published: November 2019

The research soughtly to test the effect of budget quality consisting of the budget target clarity, the budget evaluation on the budget supervision effectivity.. The population of the research was the members of parliament serving for the period of 2009-2014. The data were the collected using a quaestionnaire to 43 members of parliament, however only 34 quaestionnaires were returned.The result revealed that the budget target clarity, the budget evaluation significantly effected the supervision effectivity.
KONFLIK BATAS WILAYAH DI ERA OTONOMI MENURUT UNDANG-UNDANG 32 TAHUN 2004
Authors: Mashuri Mashuri 
Published: November 2019

Mengkaji konflik batas wilayah pada era Otonomi Daerah yang mana pada kajian ini lebih mendalam akan mengkaji tentang konflik yang terjadi berkaitan dengan tapal batas, hal ini disebabkan oleh lahirnya undang-undang Otonomi daerah akhirnya menjadi persoalan mengenai tapal batas antar kabupaten dan juga antar provinsi yang ada diIndonesia.Kerja sama antar daerah perbatasan merupakan salah satu tema penting untuk memberikan solusi atas munculnya konflik-konflik sumber daya alam (SDA) dan konflik kewenangan lainya. Walaupun belum banyak ditemukan kajian-kajian mengenai kerja sama antar daerah tersebut, akan tetapi perlu diciptakan pembagian kewenangan antar pusat- provinsi dan juga kabupten kota di Indonesia. Oleh karna itu nuansa penyeragaman kebijakan pusat terhadap heterogenitas daerah yang banyak menimbulkan konflik ti tingkat local. Masalah tersebut muncul karna adanya bebrapa kelemahan dari undang-undang Otonomi daerah Nomor 22 ahun 1999 tentang pemerintahan daerh(yang undang-undang tersebut tidak berlaku lagi sejak diundangkannya undang-undang No. 32 tahun 2004). Konflik ini terjadi dikarenakan oleh beberapa hal diantaranya adalah lemahnya koordinasi dalam penyelenggaraan fungsi pemerintahan diantara tingkat pemerintahan baik pusat, Provinsi dan juga kabupaten/kota. Disisi lain juga disebabkan oleh pengelolaaan sumber daya alam, daerah merasa lebih berhak dn memiliki wewenang sendiri. Konflik bata wilayah ini bisa dielesaikan apabila pemerintah local dan pusat berperan penting an tidak mengedepankan kepentingn elit politik.