bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Symptoms and Health Literacy of Pesticides Used among Thai Cornfield Farmers
Authors: SRISOOKKUM Taweewun , SAPBAMRER Ratana 
Published: November 2020

Background: We aimed to explain health symptoms and health literacy on the use of pesticides, investigate predicting factors and to formulate the health literacy model for the appropriate use of pesticides by cornfield farmers in the northern of Thailand.
Methods: The reliability and validity from 246 samples were selected by proportional stratified random sampling. Data were collected through a questionnaire in 2016 in Phayao province and were analysed by descriptive statistics and logistic regression.
Results: All of samples exposed from paraquat, the mean years of farm experience were 14.1 yr and five groups of health symptoms from pesticides were muscle and skeleton, epithelial/ mucosal, neurobehavioral, gastrointestinal and endocrine group. The predicting factors had influenced the health literacy of cornfield farmers regarding the use of pesticides were as following: 1) attitude on pesticides exposure (OR= 1.43, CI=1.26-1.64), 2) prevention of the practice of pesticides exposure(OR= 1.03, CI=1.01-1.05) 3) outcome of the expectation on the prevention of pesticides exposure (OR= 0.584, CI=0.41-0.82), 4) the number of secondary occupation(OR= 0.58, CI=0.38-0.89). These affecting factors were considered for the construction of a health literacy model on the use of pesticides. It could predict the model at 42.5%. The health literacy model could be equal to constant (6.85) + attitude on pesticides exposure (0.36) + behavior on the prevention of pesticides exposure (0.03) – outcome expectation on the prevention of pesticides exposure (0.54)- frequency of secondary occupation (0.53).
Conclusion: We recommend intervention of attitude, practice, outcome expectation and occupation to set up policy for health services among cornfield farmers.
11, 13-Dehydro Lactone Moiety in Gynecologic Cancer Cells
Authors: LIU Yibing , MENG Qingju , JING Li , FENG Li , NI Zhiyu 
Published: November 2020

Background: To study the anti-cancer effect of isoalantolactone, a sesquiterpene lactoneisolated from the roots of Inula heleniumon human gynecologic cancer cells.
Methods: A structure-activity relationship experiment was designed to identify the functional moiety of isoalantolactone for its significant anti-cancer activity. Five gynecologic cancer cell lines were treated with isoalantolactone. Cell proliferation was determined by MTT assay in vitro and cell apoptosis by flow cytometry.
Results: We found isoalantolactone strongly inhibited the cell proliferationofHEC-1, HAC-2, HOC-21, and HeLa cells. Its inhibitory effect was comparable to that of well-known chemotherapeutic agents, cisplatin and taxol. Furthermore, isoalantolactone induced apoptosis in HeLa cells via caspase. On the contrary, its 11, 13-dihydro derivatives had much weaker anti-proliferative activities than the parent compound.
Conclusion: Isoalantolactone exhibited strong anti-proliferative activities and apoptosis-inducing effects on gynecologic cancer cells. The 11, 13-dehydro lactone moiety was critical for its anti-proliferative activity.
DESCRIPTION OF DEPRESSION SYMPTOMS IN HEMODIALYSIS PATIENTS AT JEMURSARI HOSPITAL, SURABAYA
Authors: Wulansari Yuyun Tri , Umbul W Chatarina 
Published: November 2020

Chronic kidney disease is decreasing glomerular filtration rate of less than 15mL/minute which causes someone to undergo a hemodialysis therapy that replaces kidney function. The course of chronic kidney disease is progressive and irreversible and may cause psychological problems in hemodialysis patients such as depression. This study aimed to describe to what extent patients under hemodialysis treatment at Jemursari Hospital, Surabaya experience depression symptoms in patients. This study was descriptive research with a cross-sectional approach. The simple random sampling technique was performed to select 72 patients who had scheduled hemodialysis treatment and been qualified for the inclusion criteria. Data were then analyed using a univariate analysis in variable frequency distribution. The results show that patients with depression symptoms were mostly men as many as 31 people (43.1%), and the majority were aged 46-65 years as many as 24 people (49%). The latest formal education in most respondents was high school (23.6%). There were 38 respondents (77.5%) who got married, and most respondents were unemployed (77.5%) and had undergone hemodialysis for more than 12 months (77.5%). This study concludes that the patients under hemodialysis treatment at the hospital experienced mild depression symptoms. Keyword: hemodialysis, depression, Beck Depression Inventory.
AN OVERVIEW OF DEPRESSION TENDENCIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KEBONSARI PRIMARY HEALTHCARE CENTER, SURABAYA CITY
Authors: Shofiyati Iftitah 
Published: November 2020

Type 2 diabetes mellitus (DM) occurs due to insufficient insulin production or insulin resistance in the human body. Type 2 DM also causes physical weakness, vision problems, risk of death, and depression. This study aimed to describe depression tendencies in patients with type 2 DM under treatment in Kebonsari Primary Healthcare Center, Surabaya city. This study was a descriptive study with a cross-sectional approach. The research samples were 74 people with type 2 DM in the Kebonsari Primary Healthcare Center, Surabaya city. These respondents selected using simple random sampling had met the inclusion criteria. These repsondents were aged more than 25 years old, did not experience psychological disorders, and had suffered from type 2 diabetes mellitus for 5 years. The data analysis was done using a univariate analysis by looking at the frequency distribution of variables. The results indicate that the prevalence of patients with type 2 DM who tended to experience depression was at 50%. The majority of patients with type 2 DM who experienced depression were women (47.4%) and elderly (aged 46-65 years) (41.9%). Most of them had low education levels (62.2%), and some respondents had complications (37.8%) and poor family support (62.2%). Support from closest people such as family support can improve the adaptation of patients with the disease and can prevent psychological disorders, especially depression in patients with type 2 DM. Keyword: type 2 diabetes mellitus, family support, depression tendencies.
RECOMMENDATION OF DIPHTHERIA ANTITOXIN TO DIFFERENT SUSPECTS DURING THE DIPHTHERIA OUTBREAKS,LUMAJANG DISTRICT IN 2018
Authors: Arifin Munif 
Published: November 2020

The number of diphtheria suspects in Lumajang district was the second highest in East Java province during the diphtheria outbreaks in 2018. The number of diphtheria cases was more than 500% in 2018 compared to 2017. To give diphtheria antitoxin (DAT), the provincial diphtheria expert team consider various suspects’ characteristics for DAT recommendation as DAT supplies are limited. This case report aimed to explore and describe the relationship between diphtheria suspects’ characteristics, including age, gender, symptoms, immunization status, duration of disease, and contact status with other suspects according to the DAT recommendations from the expert team. This case report was descriptive and used a cross-sectional approach. It was conductedduring the diphtheria outbreaks and involved total samples of all suspects. Based on age, the majority of the suspects (92%)were under 19 years old. Suspects at this age were the target of an outbreak response immunization (ORI) program. Those who were not targetted to receive ORI (aged over 19 years) began to appear in November and mostly in December. The trend of non-ORI targetted age increased after the third round of ORI implementation. According to the report form parents, most suspects (46.7%) had complete immunization status, and only 6.7% of their immunization records were reported on growth chart cards. All suspects with positive diphtheria never had and know routine immunization records. The laboratory tests show only 5% were suspected with positive diphtheria with a cultural type of mitis toxigenic. As many as 32% of the total suspects were recommended for DAT treatment. The use of controlled DAT could save 1,640,000 iU. Keywords: Diphtheria, outbreak response immunization, diphtheria antitoxin.
Musa, refugio y pesadilla de poetas: la gran ciudad en la década expresionista alemana
Authors: Riesco Chueca Pascual 
Published: November 2020

Ignorada por la poesía esteticista de fin de siglo, la gran ciudad irrumpe como tema literario para la lengua alemana hacia 1910. Berlín y Viena, grandes babilonias de placer y apocalipsis, nutren una riquísima producción. Ante los insólitos paisajes de la tecnología y la masificación, se exploran nuevos estilos, en particular, los ritmos sincopados y la yuxtaposición de imágenes atrevidas e inesperadas, a modo de collage. En estas páginas se ofrece una selección de autores de la etapa expresionista, escogidos entre los menos familiares para el público español; en su práctica totalidad se trata de poemas no traducidos previamente al castellano. Ignored by the aestheticist poets of the turn of the century, the great city suddenly grows into a literary theme in Germany around 1910. Berlin and Vienna, great Babylonian metropoles of pleasure and apocalypse, deliver an overwhelming production. Against the backdrop of unprecedented landscapes, built out of technology and overcrowding, new styles are explored, in particular, the syncopated rhythms and the juxtaposition of daring and unexpected collage-like images. In the following we offer a selection of authors from the expressionist years, chosen from among the least familiar to the Spanish public. Nearly all the poems included have no previous translation into Spanish.
Sagittal alignment changes and postoperative complications following surgery for adult spinal deformity in patients with Parkinson’s disease: a multi-institutional retrospective cohort study
Authors: Kawabata Atsuyuki , Yoshii Toshitaka , Sakai Kenichiro , Hirai Takashi , Yuasa Masato , Inose Hiroyuki , Matsukura Yu , Morishita Shingo , Tomori Masaki , Torigoe Ichiro , Kusano Kazuo , Otani Kazuyuki , Arai Yoshiyasu , Shindo Shigeo , Okawa Atsushi 
Published: November 2020

Abstract
Background: Parkinson’s disease (PD) has been reported to increase the risk of postoperative complications in patients with adult spinal deformity (ASD). However, those studies are limited, and few have made direct comparisons with patients who do not have PD.Methods: A retrospective cohort study. We retrospectively reviewed all surgically treated ASD patients with at least a 2-year follow-up. Among them, 27 had PD (PD(+) group). Clinical data were collected on early and late postoperative complications as well as any revision surgery. Radiographic parameters were evaluated before and immediately after surgery and at final follow-up, including sagittal vertical axis (SVA), thoracic kyphosis, lumbar lordosis, sacral slope, and pelvic tilt. We compared the surgical outcomes and radiographic parameters of PD patients with those of non-PD patients.Results: For early complications, the PD(+) group demonstrated a higher rate of delirium than the PD(−) group. With regard to late complications, the rate of radiological pseudarthrosis was significantly higher in the PD(+) group. Rates of rod failure and revision surgery due to mechanical complications also tended to be higher, but not significantly, in the PD(+) group (p = 0.17, p = 0.13, respectively). SVA at final follow-up and loss of correction in SVA were significantly higher in the PD(+) group.Conclusion: Extra attention should be paid to perioperative complications, especially delirium, in PD patients undergoing surgery for ASD. Furthermore, loss of correction and rate of radiological pseudarthrosis were greater in these patients.
Pursue today and assess tomorrow - how students’ subjective perceptions influence their preference for self- and peer assessments
Authors: Melser Meskuere Capan , Lettner Stefan , Bäwert Andjela , Puttinger Claudia , Holzinger Anita 
Published: November 2020

Abstract
Background: Alternative assessments engage students in the assessment process to improve both short- and long-term outcomes by developing their judgments and responsibility about their own learning, and that of their peers. In this study, we investigated students’ perception towards self- and peer-assessment, their objectivity and impact on students’ learning. Methods: The study was conducted at the Medical University of Vienna. Attitudes of second year undergraduate medical students towards self- and peer-assessment, and their objectivity, appropriateness, and the impact of these assessments on students’ learning activities, was inquired using a self-developed questionnaire. Results: 423 students participated in this study. Self-assessment was found more appropriate method to assess students’ knowledge. Most of students agreed that peer-assessment is not objective (M= -0.07). Majority of students evaluated that peer assessment has no or little impact on their active and passive learning (M= -0.23, -0.35), on the other hand self-assessment was reported as a helpful tool for gaining long-term knowledge (M= 0.13) and following the content of courses (M= 0.16). Conclusion: Based on our results, students’ perspective on peer assessment were negative, on the whole, students had positive attitudes towards self-assessment and negative attitudes towards peer-assessment. This study also determined that self-assessment leads to the promotion of students’ learning.
A Novel Anatomical Locking Plate Combined With an Anterior Column Screw and Magic Screw for Acetabular Fractures Involving Both Columns: Reduction Effect and Functional Outcomes
Authors: Zhang Gongzi , Zhang Shuwei , Sui Yi , Wang Xiang , Su Xiuyun , Cao Zuo , Luo Shijie , Tang Peifu , zhang Lihai 
Published: November 2020

Abstract
BackgroundA novel anatomical locking plate (NALP) was designed. The NALP is fixed via an anterior column screw and a Magic screw to apply pressure on the acetabular fracture ends. This study was performed to compare the reduction effect and clinical outcome of the NALP versus the anatomical locking plate (ALP) for acetabular fractures involving both columns.MethodsFrom January 2013 to January 2018, 22 patients with acetabular fractures involving both columns were treated using the NALP or ALP in a single institution. The general condition and type of fracture were recorded. The NALP and ALP groups were compared regarding the Letournel fracture classification, operative approach, time from injury to operation, intraoperative bleeding volume, and operation time. The radiographic reduction outcome and hip function at final follow-up were compared between the two groups based on the Matta scores and Harris hip scores, respectively.ResultsThe NALP was used in 10 patients, while the ALP was used in 12. Three patients had transverse fractures, 12 had transverse fractures involving posterior wall, and 7 had double-column fractures. The two groups had no significantly differ regarding sex, age, affected side, Letournel fracture classification, operative approach, or follow-up duration. The time from injury to the operation was 20.70±1.2 days in the NALP group and 13.17±7.5 days in the ALP group (p=0.089). The operation time was 332.20±128.9 minutes in the NALP group and 257.50±91.6 minutes in the ALP group (p=0.128). The intraoperative blood loss volume was 1550.00±869.5 ml in the NALP group and 666.67±370.1 ml in the ALP group (p=0.011). The Matta score at final follow-up was 1.10±0.8 in the NALP group and 2.46±1.9 in the ALP group (p=0.045). The Harris hip score at final follow-up was 87.50±10.5 in the NALP group and 81.00±10.1 in the ALP group (p=0.0782).ConclusionThe NALP achieves adequate compression of the acetabular fracture ends and obtains stronger fixation than the ALP.Trial registrationChiCTR,ChiCTR2000030825. Registered 15 March 2020 - Retrospectively registered, http://www.chictr.org.cn/ChiCTR2000030825
An Open Label, Randomised Controlled Trial of Rifapentine Versus Rifampicin Based Short Course Regimens for the Treatment of Latent Tuberculosis in England: The HALT LTBI Pilot Study
Authors: Surey Julian , Stagg Helen R , Yates Thomas A , Lipman Marc , White Peter J , Charlett Andre , Muñoz Laura , Gosce Lara , Rangaka Molebogeng X , Francis Marie , Hack Vanessa , Kunst Heinke , Abubakar Ibrahim 
Published: November 2020

Abstract
BackgroundEnding the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety and the feasibility of treating LTBI in the UK using a weekly rifapentine and isoniazid regimen versus daily rifampicin and isoniazid, both self-administered for twelve weeks. MethodsAn open label, randomised, multi-site pilot trial was conducted in London, UK, between March 2015 and January 2017. Adults between 16 and 65 years with LTBI at two TB clinics who were eligible for and agreed to preventative therapy were consented and randomised 1:1 to receive either a weekly combination of rifapentine/isoniazid (‘intervention’) or a daily combination of rifampicin/isoniazid (‘standard’), with both regimens taken for twelve weeks; treatment was self-administered in both arms. The primary outcome, completion of treatment, was self-reported, defined as taking more than 90% of prescribed doses and corroborated by pill counts and urine testing. Adverse events were recorded. Results52 patients were successfully enrolled. In the intervention arm 21 of 27 patients completed treatment (77.8%, 95% confidence interval [CI] 57.7-91.4), compared with 19 of 25 (76.0%, CI 54.9-90.6) in the standard of care arm. There was a similar adverse effect profile between the two arms. ConclusionIn this pilot trial, treatment completion was comparable between the weekly rifapentine/isoniazid and the daily rifampicin/isoniazid regimens. Additionally, the adverse event profile was similar between the two arms. We conclude that it is safe and feasible to undertake a fully powered trial to determine whether self-administered weekly treatment is superior/non-inferior compared to current treatment.Trial RegistrationThe trial was funded by the NIHR, UK and registered with ISRCTN (26/02/2013-No.04379941).
Pyroptosis Related Molecules are Significant for Cartilage Degeneration
Authors: Jia Mengying , Lv Yaoguang , Xu Yingjie , Gong Zhoncheng 
Published: November 2020

Abstract
Background: Pyroptosis is the highlight topic in inflammation. However, there is rarely research on relationship between pyroptosis and temporomandibular joint osteoarthritis (TMJOA), The aim of this study is to explore whether pyroptosis related molecules are significant for condylar cartilage degeneration and to verify the clinical effects of sodium hyaluronic acid (HA) treatment on TMJOA.Methods: Patients diagnosed as temporomandibular joint internal derangement (TMJID) without condylar defect and TMJOA with condylar defect were divided into two groups. Thirty patients in each group, and they were tested for pyroptosis related molecules via synovial fluid included interleukin-1beta (IL-1β), IL-18, nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3), cysteinyl aspartate specific proteinase 1 (CASP1) with Enzyme-linked immunosorbent assay（Elisa）. Eighteen cases in TMJOA group were tested again after twice HA treatment to evaluate HA’s therapeutic effects. Results: IL-1β, IL-18, NLRP3 and CASP1 were all positive in two groups, TMJOA patients with condylar defect had higher expressions of above molecules compared with TMJID patients (P＜0.05). IL-1β, IL-18, NLRP3 were decreased with twice HA therapy (P＜0.05), there was no significant difference in CASP1 with twice HA injections (P=0.549). Conclusions: Cell pyroptosis may be involved in condylar degeneration. HA could reduce part of pyroptosis molecules to relieve inflammation.
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome in Mainland China by using XGBoost Forecasting Model
Authors: Lv Cai-Xia , An Shu-Yi , Qiao Bao-Jun , Wu Wei 
Published: November 2020

Abstract
Background: Hemorrhagic fever with renal syndrome is still attracting public attention because of its outbreak in various cities in China. It is one of the effective preventive measures to predict the peak incidence rate in the future based on the past incidence data, and implement targeted actions. In this study, we propose a multi-step prediction strategy based on XGBoost for hemorrhagic fever with renal syndrome as an extension of the one-step prediction model. Moreover, the fitting and prediction accuracy of XGBoost model will be compared with seasonal ARIMA model by different evaluation indicators. Methods: We collected monthly hemorrhagic fever with renal syndrome incidence data from 2004 to 2018 in mainland China .The part from 2004 to 2017 was divided as training set to establish the seasonal ARIMA model and XGBoost model. The rest 2018 data was used to test the prediction outcomes. In multi-step forecasting XGBoost model, one-hot encoding was used to handle seasonal features. Furthermore, series of evaluation index(MAE,MPE,MAPE,RMSE,MASE, ACF1, Theil’s U) were performed to evaluate the accuracy of multi-step forecast XGBoost model.Results: There were totally 200237 HFRS cases in China from 2004 to 2018. A slightly long-term downward trend and obvious bimodal peak seasonal character were identified in the original time series. According to the minimum CAIC value, the optimal ARIMA (3,1,0) × (1,1,0)12 model is selected. the ME , MAE, MPE, MAPE, MASE of XGBoost were higher than ARIMA model in the fitting part, whereas the RMSE of XGBoost was lower. The evaluation indicators (MAE, MPE, MAPE, RMSE , MASE) of the one-step prediction and multi-step prediction XGBoost model are all notably lower than the ARIMA model in prediction performance. Conclusions: The multi-step prediction XGBoost model showed a much better prediction accuracy and model stability in HFRS disease . In general, compared to the seasonal ARIMA model, the XGBoost model performs better when predicting complicated and non-linear data like Hemorrhagic fever with renal syndrome. Additionally Multi-step prediction models are more practical than one-step prediction in forecasting infectious diseases.