bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dropped Head Syndrome
Authors: Brodell James D. , Sulovari Aron , Bernstein David N. , Mongiovi Phillip C. , Ciafaloni Emma , Rubery Paul T. , Mesfin Addisu 
Published: January 2020

» Dropped head syndrome is a group of disorders with diverse etiologies involving different anatomical components of the neck, ultimately resulting in a debilitating, flexible, anterior curvature of the cervical spine.» Causes of dropped head syndrome include myasthenia gravis, amyotrophic lateral sclerosis, Parkinson disease, radiation therapy, and cumulative age-related changes. Idiopathic cases have also been reported.» Nonoperative treatment of dropped head syndrome includes orthotic bracing and physical therapy.» Surgical treatment of dropped head syndrome consists of cervical spine fusion to correct the deformity.» The limited data available examining the clinical and radiographic outcomes of surgical intervention indicate a higher rate of complications with the majority having favorable outcomes in the long term.
Role of the Meniscofemoral Ligaments in the Stability of the Posterior Lateral Meniscus Root After Injury in the ACL-Deficient Knee
Authors: Knapik Derrick M. , Salata Michael J. , Voos James E. , Greis Patrick E. , Karns Michael R. 
Published: January 2020

» Injuries to the posterior root of the lateral meniscus occur frequently in acute knee injuries with concomitant tearing of the anterior cruciate ligament (ACL).» The meniscofemoral ligaments (MFLs), consisting of the anterior MFL (ligament of Humphrey) and the posterior MFL (ligament of Wrisberg), as well as the osseous attachment of the meniscal root, stabilize the lateral meniscus, enabling appropriate load transmission and maintenance of contact forces within the lateral compartment of the knee during loading and range of motion.» In the setting of an ACL injury to the knee with osseous root injury of the posterior root of the lateral meniscus, the MFLs (when present) may stabilize the lateral meniscus against meniscal extrusion, thereby maintaining appropriate contact mechanics within the knee, decreasing the risk of subsequent chondral and meniscal injury and the development of premature osteoarthritis.» Additional study on the indications for posterior meniscal root repair during ACL reconstruction is warranted since the ideal management of lateral root injury in the MFL-intact knee remains unknown.
Analisis Psikologi Tokoh dalam Filosofi Kopi untuk Menentukan Materi Pembelajaran Sastra
Authors: Puspita Ayunda Riska 
Published: January 2020

Karya sastra merupakan salah satu media untuk memotivasi siswa. Motivasi tersebut biasanya disampaikan dalam pesan yang terkandung dalam karya sastra. Salah satu pembawa pesan dalam karya sastra adalah melalui tokoh yang digambarkan oleh pengarang. Untuk mengetahui pesan yang terkandung dalam karya sastra melalui tokohnya, dapat dianalisis melalui psikologi tokoh dengan pendekatan psikoanalisa yang disampiakan oleh Freud. Psikoanalisa Freud menganalisis tiga unsur dalam diri manusi, yakni id, ego, dan super ego. Ketiga sistem tersebut bekerja secara seimbang pada diri Ben. Semula Ben dikuasai oleh id, dan ego selalu berjalan dengan id. Kemudian sedikit demi sedikit konflik-konflik yang dialami oleh Ben mengakibatkan ego tak sejalan lagi dengan id. Hal ini mengakibatkan superego muncul pada diri Ben, dan menjalankan fungsinya. Analisis ini berkontribusi dalam pembelajaran sastra, yakni kontribusi pada aspek afektif dan kognisi. Pada aspek afektif, analisis ini dapat memberi motivasi peserta didik agar menjadi manusia yang tidak ambisi dalam mengejar kesempurnaan karena tidak ada yang sempurna di dunia ini. Pada aspek kognitif, kajian ini dapat memberikan kontribusi untuk menambah pengetahuan mahasiswa tentang analisis karya sastra, khususnya cerpen.
Pengaruh Model Pembelajaran Scramble Dengan Media Question Card Terhadap Hasil Belajar IPA Siswa Kelas IV SDN Kertosari II Kabupaten Madiun
Authors: Kusumawati Naniek 
Published: January 2020

Kurang antusiasnya siswa dalam kegiatan pembelajaran mengakibatkan perlu dikembangkan model dan media pembelajaran yang efektif. Siswa merasa bosan dengan model pembelajaran konvensional yang sering digunakan guru. Dalam memilih model pembelajaran yang tepat haruslah memperhatikan kondisisiswa, sifat materi bahan ajar, fasilitas media yang tersedia. Model pembelajaran Scramble dengan media Question Card merupakan daya dukung utama bagi guru untuk menciptakan suasana belajar siswa secara aktif, menumbuhkan kreativitas dan semangat siswa untuk mempelajari materi-materi yang ada di dalamnya. Penelitian ini merupakan jenis penelitian True Eksperimental. Desain penelitian Postest Only Control desain. Subjek penelitian ini adalah siswa kelas IV sebanyak 48 siswa yang terdiri dari 24 siswa kelas IV eksperimen dan 24 siswa kelas kontrol. Penentuan sampel di dalam penelitian ini menggunakan simple random sampling. Pengumpulan data menggunakan teknik tes. Dalam menganalisis data menggunakan metode statistik dengan rumus uji-t dengan taraf signifikan 5%. Hasil penelitian menunjukkan bahwa ada pengaruh signifikan model pembelajaran Scramble dengan media Question Card terhadap hasil belajar IPA siswa kelas IV SDN Kertosari II di Kabupaten Madiun. Ini terlihat pada hasil belajar nilai rata-rata siswa yang diajar menggunakan model tersebut 82,91, sedangkan siswa yang diajarkan dengan model konvensional 68,75, serta diperoleh = 6,074,lebih besar dari = 1,679.
Implementasi Pendidikan Karakter Religius Melalui Pembelajaran Akidah Akhlak Di Madrasah Ibtidaiyah Nurul Yaqin Kota Bogor
Authors: Hasanah Faridatul , Kamalludin Chodidjah , Kamalludin Kamalludin 
Published: January 2020

Tujuan Penelitian ini adalah sebagai berikut : (1. ) Untuk mengetahui ruang lingkup materi Akidah Akhlak di MI Nurul Yaqin Kota Bogor, (2). Untuk mengetahui cara apa saja yang dapat meningkatkan nilai-nilai karakter religius dikalangan MI Nurul Yaqin Kota Bogor, (3). Untuk mengetahui hambatan-hambatan yang dihadapi guru dalam mengajarkan Akidah Akhlak dalam membina karakter religius siswa di MI Nurul Yaqin Kota Bogor, (4). Untuk mengetahui metode apa saja yang bisa menerapkan pendidikan Karakter dalam Pembelajaran Akidah Akhlak, (5). Untuk mengetahui media apa saja yang bisa digunakan dalam pembelajaran Akidah Akhlak, (6) Untuk mengetahui cara penerapan pendidikan karakter melalui pembelajaran Akidah Akhlak di MI Nurul yaqin Kota Bogor. Jenis penelitian yang digunakan yaitu penelitiaan lapangan (field research) di MI Nurul Yaqin-Kota Bogor. Metode penelitiannya menggunakan kualitatif. Teknik pengumpulan data dengan observasi partisipatif, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa : 1). Ruang lingkup materi Akidah Akhlak meliputi kalimat Thayyibah, sifat-sifat Asmaul Husna, beriman kepada kitab-kitab Allah, akhlak terpuji dan akhlak tercela. 2). Cara-cara meningkatkan nilai karakter reigius, (3) mengetahui hambatan yang dihadapi guru yaitu mengurangi dan memecahkan permasaahan atau hambatan dalam belajar baik dari siswa, guru (internal) ataupun luar peserta didik (eksternal), (4) Metode yang digunakan saat pembelajaran Akidah Akhlak diantaranya yaitu ceramah, diskusi, drama atau role playing, praktek langsung atau demonstrasi dan tanya jawab. (5). Media yang dapat digunakan dalam pembelajaran Akidah Akhlak adalah media visual seperti gambar atau slide dan audio visual berupa film atau video (6) Cara penerapan pendidikan Karakter dalam pembelajaran Akidah Akhlak dapat melalui contoh sehari-hari, mengaitkan nilai karakter dengan cerita dan demonstrasi nilai karakter atau praktek langsung oleh siswa sendiri.
Pengaruh Kepemimpinan Kepala Madrasah dan Motivasi Kerja Guru Terhadap Kreativitas Guru MTsN se-Kabupaten Madiun
Authors: Azizah Mukhtar Kholifatul 
Published: January 2020

Artikel ini ingin menganalisis tentang pengaruh kepemimpinan kepala madrasah dan motivasi kerja guru terhadap kreativitas guru MTsN se-kabupaten Madiun. Dimana kreativitas guru dalam pembelajaran menjadi sangat penting dalam keberhasilan pembelajaran dan tujuan pendidikan di sekolah, dimana kreativitas guru sangat diperlukan agar guru dapat menjalankan tugas dan peranannya dalam proses belajar mengajar dengan maksimal. Kreativitas guru merupakan daya kreatif untuk dapat menciptakan iklim pembelajaran yang menarik dan menyenangkan sehingga tercipta suasana pembelajaran yang kondusif. Kreativitas guru juga sangat penting untuk mendorong kreativitas peserta didik, sebab dengan adanya guru yang kreatif, maka siswa juga akan belajar untuk berkreasi. Penelitian ini ingin menguji tentang pengaruh kepemimpinan kepala sekolah dan motivasi kerja guru terhadap kreativitas guru MTsN se Kabupaten Madiun.
Metode penelitian yang digunakan menggunakan pendekatan penelitian kuantitaif dengan jenis penis penelitian expost-facto, sampel yang dijadikan penelitian ialah MTsN se Kabupaten Madiun dengan populasi guru PNS sebanyak 289 guru, teknik pengambilan sampel menggunakan Area Random Sampling (Cluster Sampling), yaitu pengambilan sampel secara acak dan berumpun.
Hasil penelitian dalam penelitian ini ialah terdapat pengaruh yang positif dan signifikan antara kepemimpinan kepala madrasah dan motivasi kerja guru terhadap kreativitas guru Pegawai Negeri Sipil MTsN se-Kabupaten Madiun tahun pelajaran 2017/2018 yang ditunjukkan dengan hasil uji F yaitu nilai Fhitung lebih besar dari Ftabel (15,123 > 3,040). Dan pada taraf signifikan 5% dengan koefisien determinan 0,257 sehingga dapat disimpulkan bahwa kreativitas guru dipengaruhi oleh kepemimpinan kepala madrasah dan motivasi kerja guru sebesar 25,7%. Data hasil penelitian ini menunjukkan bahwa kepemimpinan kepala madrasah dan motivasi kerja menyumbang sebesar 25,7% dan sisanya 74,3% dipengaruhi variabel lain baik secara internal seperti rasio, bakat khusus, perasaan, dan intuisi. Maupun eksternal seperti latar belakang pendidikan guru, pelatihan-pelatihan guru, pengalaman mengajar guru, dan faktor kesejahteraan guru
Investigation on susceptible variants to arrhythmia in forensic autopsy cases of SCDs caused by cardiomyopathy: assessment with the candidate SNPs
Authors: Tian Mei-Hui , Jia Yu-Qing , Zhao Mao-Mao , Huo Zhi-Xin , Zhang Si-Yi , Zhan Xiao-Ni , Yang Xin-Rui , Zhu Bao-Li , Pang Hao 
Published: January 2020

Abstract
The authors have withdrawn this preprint from Research Square
Extended spectrum β-lactamase (ESBL)-producing Escherichia coli inactivation by UVA-LED irradiation system in a Japanese hospital
Authors: Ulfa Maria , Azuma Momoyo , Sato Masami , Shimohata Takaaki , Fukushima Shiho , Kido Junko , Nakamoto Mariko , Uebanso Takashi , Mawatari Kazuaki , Emoto Takahiro , Akutagawa Masatake , Kinouchi Yohsuke , Takahashi Akira 
Published: January 2020

Abstract
The authors have withdrawn this preprint from Research Square
Origin and Evolution of Emerging Liaoning Virus（genus Seadornavirus, family Reoviridae)&nbsp;
Authors: Zhang Jun , Liu Hong , Wang Jiahui , Wang Jiheng , Zhang Jianming , Wang Jiayue , Zhang Xin , Ji Hongfang , Ding Zhongfen , Xia Han , Zhang Chunyang , Zhao Qian , Liang Guodong 
Published: January 2020

Abstract
The authors have withdrawn this preprint from Research Square
Evaluating the effects of synthetic POM cycles and NAD kinase expression on fatty alcohol production in Saccharomyces cerevisiae﻿
Authors: McNeil Bonnie A , Khalifa Charfeddine , Krishnan Anagha , Stuart David T 
Published: January 2020

Abstract
Background: NADPH-dependent enzymes play important roles in many anabolic reactions and the availability of redox cofactors can influence metabolic flux ultimately influencing titers of bioproducts produced by engineered microbial cells. This may be especially true of oleochemical production when carbon flux through the highly NADPH-dependent fatty acid biosynthesis pathway is increased. While pathway specific approaches are often applied to counter redox imbalance, a study evaluating generalized approaches to improved NADPH availability is lacking in Saccharomyces cerevisiae . Results: Here, we have created four unique synthetic Pyruvate-Oxaloacetate-Malate “POM” cycles consisting of either of the endogenous isoforms of pyruvate carboxylase ( PYC1 or PYC2 ), a modified version of malate dehydrogenase ( ‘MDH1 or ‘MDH2 ), and a truncated cytosolic form of the endogenous malic enzyme ( sMAE1 ). Only the POM cycle that combined expression of PYC1 , ‘MDH2 , and sMAE1 increased the titer of fatty alcohols produced; however, it did so in two unique fatty alcohol producing strains. In a FAS1 overexpression background, expression of this synthetic POM cycle increased fatty alcohol titers by 40% from 49.0 ± 2.2 mg/L to 68.6 ± 3.3 mg/L and showed similar results in a zwf1 deletion strain. The effect of overexpression of the endogenous NAD+ kinases UTR1 , YEF1 , and a cytosolic version of POS5 were also tested. We found that expression of POS5c resulted in an ~35% increase in fatty alcohol titer, while the overexpression of the UTR1 or YEF1 did not significantly influence titers. In these minimally engineered cells, combined overexpression of PYC1 , ‘ MDH2 , sMAE1 and POS5c did not further increase titers Conclusions: Overexpression of PYC1 in conjunction with ‘MDH2 and sMAE1 results in a synthetic POM cycle which can be utilized to improve fatty alcohol production in engineered strains of S. cerevisiae . Additionally, overexpression of a truncated version of POS5 ( POS5c ) results in similar increases in fatty alcohol production. These findings may serve to provide a generalized mechanism to increase NADPH production in engineered cells, resulting in increased bioproduct titers.
A novel homozygous premature stop mutation in TNNT2 associates with Feline cardiomyopathy
Authors: McNamara James W , Schuckman Maggie , Becker Richard C , Sadayappan Sakthivel 
Published: January 2020

Abstract
Background: Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart and the most common cause of sudden cardiac death in the young. HCM is considered a disease of the sarcomere owing to the large number of mutations in genes encoding sarcomeric proteins. The riddle lies in discovering how these mutations lead to disease. As a result, treatments to prevent and/or treat HCM are limited to invasive surgical myectomies or ablations. Recently, a cohort of Maine Coon cats was identified as carrying an alanine to proline substitution at amino acid 31 of the sarcomeric protein, cardiac myosin binding protein-C, encoded by MYBPC3 . Additional mutations in MYBPC3 and MYH7 have also been associated with HCM in cats. In this study, we expand the spectrum of genes associated with HCM in cats. Results: Next Generation Whole Genome sequencing was performed using DNA isolated from peripheral blood of a Maine Coon with cardiomyopathy that tested negative for the above A31P mutation. Through risk stratification of variants, we identified a novel, homozygous truncating mutation in cardiac troponin-T ( TNNT2 ), also associated with HCM in humans. Both parents tested heterozygous for the mutation, but were unaffected by the disease. Conclusions: In summary, we are the first to demonstrate the association of TNNT2 mutations and HCM in a cat, suggesting this gene should be added to the testing panel of genes when performing genetic testing for HCM in cats.
The AO Trauma CPP Bone Infection Registry: epidemiology and outcomes on Staphylococcus aureus infection in long bones and joints
Authors: Morgenstern Mario , Erichsen Christoph , Militz Matthias , Xie Zhao , Peng Peng Jiachen , Stannard James , Metsemakers Willem-Jan , Schaefer Dirk , Alt Volker , Soballe Kjeld , Nerlich Michael , Buckley Richard E. , Blauth Michael , Suk Michael , Leung Frankie , Barla Jorge , Yukata Kiminori , Qing Bi , Schwarz Edward M , Kates Stephen L. 
Published: January 2020

Abstract
Background Bone infection is a serious complication associated with orthopedic surgery, and Staphylococcus aureus (S. aureus) is a common pathogen. As the optimal treatment requires an understanding of the patient-specific host-pathogen interaction, we developed a biospecimen registry (the AO Trauma CPP Bone Infection Registry) to collect clinical data, bacterial isolates, and serum from patients treated for bone infection caused by S. aureus. MethodsA prospective multicenter multicontinental registry with a follow-up period of 12 months was set up to include adult patients (18 years or older) with culture-confirmed S. aureus infection in long bones after fracture fixation or arthroplasty. Baseline patient attributes and details on infections and treatments were recorded. Blood and serum samples were taken at baseline, 6, and 12 months. Patient outcomes were assessed with the Short Form-36, Parker Mobility Score, and Katz Activities of Daily Living at baseline, 1, 6, and 12 months. Complications, re-hospitalization, and outcomes were recorded. Aside from descriptive summary analyses, changes from baseline were analyzed using the mixed-effects model and Wilcoxon sign rank test. Analyses using full analysis population and per protocol population were performed, and when appropriate, additional sensitivity analyses. This study was registered in ClinicalTrials.gov: NCT01677000.ResultsTwo hundred and ninety-two patients with infections originating from fracture fixation (n=157, 53.8%), prosthetic joint infection (n=86, 29.5%), and osteomyelitis (n= 49, 16.8%) were enrolled (Table 1). Methicillin resistant S. aureus was detected in 82 patients (28.4%), with the highest proportion found among patients from North American sites (n=39, 48.8%) and the lowest from Central European sites (n=18, 12.2%). Patient outcomes had improved statistically significant at 6 and 12 months in comparison to baseline. The SF-36 Physical Component Summary mean (95% CI) score, however, did not reach 50, at 12 months. The cure rate at the end of the study period was 62.1%.ConclusionThe AO Trauma CPP Bone Infection Registry provides unique insights into the epidemiology and outcomes of S. aureus long-bone infections. It also contains annotated biospecimens for future research.Although patients' health status improved after treatment, less than two-thirds were cured at one year.
Maternal and Fetal CD4+CD25+CD127low/- Regulatory T Cells in Pregnancies with Gestational Diabetes, Preeclampsia, and Premature Rupture of Membranes
Authors: Zhao Yuan-yuan , Zhang Xiaolu , Sun Hong , Chen Lei , Ma Ding , Kwak-Kim Joanne , Wang Wen-juan 
Published: January 2020

Abstract
Background Regulatory T cells (Tregs) play a crucial role in maternal-fetal tolerance, but little is known about the characteristic of Tregs in peripheral blood (PB), maternal-fetal interface and cord blood (CB) in normal and complicated pregnancies with preeclampsia (PE), gestational diabetes mellitus (GDM) and premature rupture of membranes (PROM). Methods PB, retro-placental blood (RPB), and CB were collected immediately after delivery in women with normal full-term pregnancy (NP), PE, GDM, and PROM. The proportion of CD4 + CD25 + CD127 low/- T cells (Tregs) and the expression of PD-1, GITR, HLA-G and CTLA-4 on T cell subsets were investigated by flow cytometric analysis. The data were analyzed based on sample origins (PB, RPB, and CB) and the obstetrical study groups (NP, PE, GDM, and PROM). Results The proportions of Tregs in PB, RPB, and CB from NP were significantly higher than the other obstetrical groups (P < 0.01, respectively). However no significant differences were present among the PE, GDM and PROM groups (P = NS). The proportion of PD-1 + and GITR + Tregs in RPB and PB as well as PD-1 + Tregs in CB from NP were significantly higher than those of the same origin in each obstetrical study group (P < 0.01, respectively). There were no differences in HLA-G + and CTLA-4 + Tregs between different origins in each obstetrical study group. In NP, the proportion of PD-1 + Tregs was significantly decreased in CB as compared to those of PB and RPB (P < 0.05, respectively). Among the four groups, the proportion of GITR + Tregs were significantly higher in PB as compared to those of CB and RPB (P < 0.01, respectively). The proportion of HLA-G + Tregs in PB was significantly lower than that of CB and RPB (P < 0.01, respectively). The proportion of CTLA-4 + Tregs had no significant differences (P = NS). Conclusions In conclusion, the proportion and characteristics of Tregs vary in the maternal, fetal and maternal-fetal junction at the time of delivery. The different feature and density of Tregs in maternal and fetal tissue may suggest the multiple and complicated roles of Tregs during pregnancy.
Choice between home and health institutional births in the era of Kenya’s maternity subsidy
Authors: Musau Abednego Muema , Ng'ang'a Tabitha Kiriti 
Published: January 2020

Abstract
Background Adverse maternal and neonatal outcomes disproportionately afflict low and middle-income countries, which experience high-unmet need for safe and skilled attendance at birth. This study sought to investigate how choices for place of birth were made in Kenya during the era of a national maternal subsidy. Methods The study employed data from the Kenya Demographic Health Survey 2014 and involved data from women who experienced a birth around the time when the maternity subsidy was in place. After testing for multi-collinearity of variables and addressing endogenous endogeneity using two-stage residual inclusion, probit regression models were estimated. The choice for place of birth was employed as a binary outcome variable. Results Overall, data from 4,772 women were included in the analysis. The women’s mean age was 27.7 years and majority (83.8%) were married or staying with their sexual partners. Among these women, 2748 (57.5%) had elected institutional births. Regression analysis illustrated that woman’s age, the woman and partner’s education, economic empowerment, low parity, low county poverty headcount rate and access to medical insurance. Further, access to complementary reproductive services such as antenatal care and family planning and the existence of the maternity subsidy were associated with increased likelihood to choose deliveries in health facilities. Conclusions The existence of the maternal subsidy confers women increased potential to elect health institutions as a preferred place for birth, although this was influenced by other factors. These findings imply that investments, which prevent teen pregnancies, reduce domestic and national poverty, increase education attainment, expand autonomy of women in decision making and promote access to the continuum of reproductive health services can optimize choice making during the existence of the maternity subsidy favoring access to safe institutional births.