bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Resistance in Typhoidal Salmonella: Surveillance for Enteric Fever in Asia Project, 2016–2019
Authors: Qamar Farah N , Yousafzai Mohammad T , Dehraj Irum F , Shakoor Sadia , Irfan Seema , Hotwani Aneeta , Hunzai Muhammad J , Thobani Rozina S , Rahman Najeeb , Mehmood Junaid , Hemlock Caitlin , Memon Ashraf M , Andrews Jason R , Luby Stephen P , Garrett Denise O , Longley Ashley T , Date Kashmira , Saha Samir K 
Published: October 2020

Abstract

Background
Clinicians have limited therapeutic options for enteric as a result of increasing antimicrobial resistance, and therefore typhoid vaccination is recommended as a preventive measure. As a part of the Surveillance for Enteric Fever in Asia Project (SEAP), we investigated the extent measured the burden of antimicrobial resistance (AMR) among confirmed enteric fever cases in Bangladesh, Nepal, and Pakistan.

Methods
From September 2016–September 2019, SEAP recruited study participants of all age groups from its outpatient, inpatient, hospital laboratory, laboratory network, and surgical sites who had a diagnosis of febrile illness that was either suspected or blood culture confirmed for enteric fever. Antimicrobial resistance of isolates was determined by disc diffusion using Clinical and Laboratory Standard Institute cut-off points. We reported the frequency of multidrug resistance (MDR)(resistance to ampicillin, cotrimoxazole, and chloramphenicol), extensive drug resistance (XDR) (MDR plus non-susceptible to fluoroquinolone and any 3rd generation cephalosporins), and fluoroquinolone (FQ) and azithromycin non-susceptibility.

Results
We enrolled 8,705 blood culture confirmed enteric fever cases: 4,873 (56%) from Bangladesh, 1,602 (18%) from Nepal and 2,230 (26%) from Pakistan. Of these, 7,591 (87%) were Salmonella Typhi and 1114 (13%) were S. Paratyphi. MDR S. Typhi was identified in 17% (701/4065) of isolates in Bangladesh, and 1% (19/1342) in Nepal. In Pakistan, 16 % (331/2084) of S. Typhi isolates were MDR, and 64% (1319/2074) were XDR. FQ nonsusceptibility among S. Typhi isolates was 98% in Bangladesh, 87% in Nepal, and 95% in Pakistan. Azithromycin non-susceptibility was detected in 77 (2%) in Bangladesh, 9 (.67%) in Nepal and 9 (.59%) isolates in Pakistan. In Pakistan, three (2%) S. Paratyphi isolates were MDR; no MDR S. Paratyphi was reported from Bangladesh or Nepal.

Conclusions
Although AMR against S. Paratyphi was low across the three countries, there was widespread drug resistance among S. Typhi, including FQ non-susceptibility and the emergence of XDR S. Typhi in Pakistan, limiting treatment options. As typhoid conjugate vaccine (TCV) is rolled out, surveillance should continue to monitor changes in AMR to inform policies and to monitor drug resistance in S. Paratyphi, for which there is no vaccine.
Cost-Effectiveness of an Adjuvanted Hepatitis B Vaccine (HEPLISAV-B) in Patients With Inflammatory Bowel Disease
Authors: Corral Juan E , Kwon Joshua Y , Caldera Freddy , Pungpapong Surakit , Spaulding Aaron C , Borah Bijan J , Moriarty James P , Farraye Francis A 
Published: October 2020

AbstractBackgroundCompare the cost-effectiveness of 2 recombinant hepatitis B virus (HBV) vaccines in patients with inflammatory bowel disease (IBD).MethodsMarkov models were developed for 2 IBD cohorts: (1) 40-year-old patients prior to starting IBD treatment and (2) 40-year-old patients already receiving therapy. Cohort A received full vaccination series, cohort B had primary vaccine failure and received a vaccine booster. Two vaccines were compared: adjuvanted HEPLISAV-B and nonadjuvanted Engerix-B. Clinical probabilities of acute hepatitis, chronic hepatitis, cirrhosis, fulminant hepatic failure and death, treatment costs, and effectiveness estimates were obtained from published literature. A lifetime analysis and a US payer perspective were used. Probabilistic sensitivity analyses were performed for different hypothetical scenarios.ResultsAnalysis of cohort A showed moderate cost-effectiveness of HEPLISAV-B ($88,114 per quality-adjusted life year). Analysis of cohort B showed increased cost-effectiveness ($35,563 per quality-adjusted life year). Changing Engerix-B to HEPLISAV-B in a hypothetical group of 100,000 patients prevented 6 and 30 cases of acute hepatitis; and 4 and 5 cases of chronic hepatitis annually for cohorts A and B, respectively. It also prevented 1 and 2 cases of cirrhosis, and 1 and 2 deaths over 20 years for each cohort. Cost-effectiveness was determined by vaccination costs, patient age, and progression rate from chronic hepatitis to cirrhosis.ConclusionsHEPLISAV-B is cost-effective over Engerix-B in patients receiving immunosuppressive therapy for IBD. Benefits increase with population aging and lower costs of vaccines. We advocate measuring levels of HBV antibodies in patients with IBD and favor adjuvanted vaccines when vaccination is needed.
Climate extremes, variability, and trade shape biogeographical patterns of alien species
Authors: Liu Xuan , Rohr Jason R , Li Xianping , Deng Teng , Li Wenhao , Li Yiming 
Published: October 2020

AbstractUnderstanding how alien species assemble is crucial for predicting changes to community structure caused by biological invasions and for directing management strategies for alien species, but patterns and drivers of alien species assemblages remain poorly understood relative to native species. Climate has been suggested as a crucial filter of invasion-driven homogenization of biodiversity. However, it remains unclear which climatic factors drive the assemblage of alien species. Here, we compiled global data at both grid scale (2,653 native and 2,806 current grids with a resolution of 2° × 2°) and administrative scale (271 native and 297 current nations and sub-nations) on the distributions of 361 alien amphibians and reptiles (herpetofauna), the most threatened vertebrate group on the planet. We found that geographical distance, a proxy for natural dispersal barriers, was the dominant variable contributing to alien herpetofaunal assemblage in native ranges. In contrast, climatic factors explained more unique variation in alien herpetofaunal assemblage after than before invasions. This pattern was driven by extremely high temperatures and precipitation seasonality, 2 hallmarks of global climate change, and bilateral trade which can account for the alien assemblage after invasions. Our results indicated that human-assisted species introductions combined with climate change may accelerate the reorganization of global species distributions.
Distinct Adult Eclosion Traits of Sibling SpeciesRhagoletis pomonellaandRhagoletis zephyria(Diptera: Tephritidae) Under Laboratory Conditions
Authors: Yee Wee L , Goughnour Robert B , Feder Jeffrey L 
Published: October 2020

AbstractClosely related phytophagous insects that specialize on different host plants may have divergent responses to environmental factors. Rhagoletis pomonella (Walsh) and Rhagoletis zephyria Snow (Diptera: Tephritidae) are sibling, sympatric fly species found in western North America that attack and mate on plants of Rosaceae (~60 taxa) and Caprifoliaceae (three taxa), respectively, likely contributing to partial reproductive isolation. Rhagoletis zephyria evolved from R. pomonella and is native to western North America, whereas R. pomonella was introduced there. Given that key features of the flies’ ecology, breeding compatibility, and evolution differ, we predicted that adult eclosion patterns of the two flies from Washington State, USA are also distinct. When puparia were chilled, eclosion of apple- and black hawthorn-origin R. pomonella was significantly more dispersed, with less pronounced peaks, than of snowberry-origin R. zephyria within sympatric and nonsympatric site comparisons. Percentages of chilled puparia that produced adults were ≥67% for both species. However, when puparia were not chilled, from 13.5 to 21.9% of apple-origin R. pomonella versus only 1.2% to 1.9% of R. zephyria eclosed. The distinct differences in eclosion traits of R. pomonella and R. zephyria could be due to greater genetic variation in R. pomonella, associated with its use of a wider range of host plants than R. zephyria.
A case report of a coronary artery fistula to coronary sinus with giant aneurysm: risk does not end with repair
Authors: Poretti Giulia , Lo Rito Mauro , Varrica Alessandro , Frigiola Alessandro 
Published: October 2020

Abstract

Background
Isolated coronary arteriovenous fistulas are extremely rare, accounting for 0.08–0.4% of all congenital heart disease. Closure of the fistula is recommended in cases of large dimensions, relevant left–right shunt, or ischaemic events. Thrombosis of the coronary aneurysms may occur as a postoperative complication.

Case summary
We report a case of a coronary fistula between the circumflex artery and coronary sinus with giant aneurysm. After a failed percutaneous closure attempt, the patient was surgically treated without major postoperative complications. Despite therapeutic anticoagulation and antiplatelet therapy, she presented at clinical follow-up with thrombosis of the dilated coronary artery without signs or symptoms of ischaemia.

Discussion
Management of coronary artery fistula may be challenging in cases in which initial percutaneous closure is unsuccessful. This particular case also highlights the importance of close follow-up, despite optimal therapy, to detect potentially lethal complications related to the low flow in the dilated coronary aneurysm.
His bundle pacing capture threshold stability during long-term follow-up and correlation with lead slack
Authors: Beer Dominik , Subzposh Faiz A , Colburn Shaun , Naperkowski Angela , Vijayaraman Pugazhendhi 
Published: October 2020

Abstract

Aims
His bundle pacing (HBP) is the most physiologic form of pacing. Long-term HBP capture threshold stability and its relation to lead characteristics at the time of implantation have not been adequately described. The aim of this study was to characterize HB capture threshold in follow-up and to identify potential lead characteristics predictive of lead capture instability.

Methods and results
Consecutive patients with successful HBP for bradycardia indications were identified from the Geisinger HBP registry. His bundle capture thresholds, baseline comorbidities, and radiographic lead slack characteristics were analysed. An increase in HB capture threshold ≥1 V above implant values at any time during follow-up was tracked. Forty-four of the 294 studied (15%) experienced HB capture threshold increase by ≥ 1 V. Threshold increase was seen early (41% by 8 weeks, 66% by 1 year). Eighteen (6%) patients required lead revision in follow-up. Abnormal slack shape was associated with a trend toward capture threshold increase [hazard ratio (HR) 2.07; 95% confidence interval (CI) 0.9–4.6; P = 0.08]. Non-perpendicular angle of lead insertion on radiography was associated with the capture threshold increase (HR 2.81, 95% CI 1.4–5.8; P &lt; 0.01).

Conclusion
His bundle capture threshold remains stable in the majority (85%) of patients. Implant characteristics may predict the threshold rise. Further evaluation of the aetiology of threshold increase and design changes in lead and delivery systems may lead to chronically stable capture thresholds.
Lithospheric dynamics in the vicinity of the Tengchong volcanic field (southeastern margin of Tibet): an investigation usingPreceiver functions
Authors: Peng Hengchu , Badal José , Hu Jiafu , Yang Haiyan , Liu Benyu 
Published: October 2020

SUMMARYTengchong volcanic field (TVF) in the northern Indochina block lies in a critical area for understanding complex regional dynamics associated with continent–continent convergence between the Indian and Eurasian plates, including northeastward compression generated by subduction of the Indian Plate beneath the Burma Arc, and southeastward lateral extrusion of the crust from below central Tibet. We gathered 3408 pairs of P receiver functions with different frequencies and calculated the splitting parameters of the Moho-converted Pms phase. An anisotropic H-κ stacking algorithm was used to determine crustal thickness and Vp/Vs ratios. We also inverted for the detailed S-velocity structure of the crust and upper mantle using a two-step inversion technique. Finally, we mapped the topography of the lithosphere–asthenosphere boundary. Results show fast-wave polarization directions with a dominant NE–SW orientation and delay times varying between 0.19 and 1.22 s, with a mean of 0.48 ± 0.07 s. The crustal Vp/Vs ratio varies from 1.68 to 1.90 and shows a maximum value below the central part of the TVF, where there is relatively thin crust (∼35–39 km) and a pronounced low-velocity anomaly in the middle–lower crust. The depth of the lithosphere–asthenosphere boundary ranges from 53 to 85 km: it is relatively deep (∼70–85 km) in the vicinity of the TVF and relatively shallow in the south of the study area. In the absence of low shear wave velocity in the upper mantle below the TVF, we propose that the low-velocity anomaly in the lower crust beneath the TVF derives from the upper mantle below the neighbouring Baoshan block.
Fecal Calprotectin Is Highly Effective to Detect Endoscopic Ulcerations in Crohn’s Disease Regardless of Disease Location
Authors: Buisson Anthony , Mak Wing Yan , Andersen Michael J , Lei Donald , Pekow Joel , Cohen Russell D , Kahn Stacy A , Pereira Bruno , Rubin David T 
Published: October 2020

Abstract

Background
As the reliability of fecal calprotectin (Fcal) remains debatable to detect endoscopic ulcerations in patients with pure ileal Crohn’s disease (CD), we aimed to compare its performances with those observed in patients with colonic or ileocolonic location.

Methods
Using a prospectively maintained database, we analyzed 123 CD patients with Fcal measurement and ileocolonoscopy performed within 1 month with no therapeutic intervention during this interval. Receiver operating characterstic curves (ROC) were used to determine the best Fcal threshold to detect endoscopic ulcerations, taking into account the clinical relevance and usual recommended indices. Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) were presented with 95% confidence intervals.

Results
The mean Fcal level was significantly higher in patients with endoscopic ulcerations in the L1 group (P = 0.025) and the L2-L3 group (P &lt; 0.001). Using ROC curves, Fcal &gt;200 µg/g and Fcal &gt;250 µg/g were the best thresholds to detect endoscopic ulcerations in the L1 group (sensitivity = 75.0, 95% CI, 47.6–92.7; specificity = 87.5, 95% CI, 67.6–97.3; PPV = 80.0, 95% CI, 51.9–95.7; and NPV = 84.0; 95% CI, 63.9–95.5) and in the L2-L3 group (sensitivity = 84.1 95% CI, 69.9–93.4; specificity = 74.4, 95% CI, 57.9–87.0; PPV = 78.7, 95% CI, 64.3–89.3, and NPV = 80.6, 95% CI, 64.0–91.8), respectively. We compared the AUC between L1 and L2-L3 groups, and no difference was shown (0.89 vs 0.84, respectively, P = 0.46). We also compared 2-by-2 sensitivity, specificity, PPV, NPV, and accuracy and we did not observe any significant difference.

Conclusion
Fecal calprotectin is highly effective to detect endoscopic ulcerations regardless of CD location but requires a lower cutoff value in patients with pure ileal involvement.
Comparison of left ventricular unloading strategies on venoarterial extracorporeal life support
Authors: Hasde Ali İhsan , Sarıcaoğlu Mehmet Cahit , Dikmen Yaman Nur , Baran Çağdaş , Özçınar Evren , Çakıcı Mehmet , İnan Mustafa Bahadır , Akar Ahmet Ruchan 
Published: October 2020

AbstractOBJECTIVESOur goal was to compare the haemodynamic effects of different mechanical left ventricular (LV) unloading strategies and clinical outcomes in patients with refractory cardiogenic shock supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO).METHODSA total of 448 patients supported with VA-ECMO for refractory cardiogenic shock between 1 March 2015 and 31 January 2020 were included and analysed in a single-centre, retrospective case–control study. Fifty-three patients (11.8%) on VA-ECMO required LV unloading. Percutaneous balloon atrial septostomy (PBAS), intra-aortic balloon pump (IABP) and transapical LV vent (TALVV) strategies were compared with regards to the composite rate of death, procedure-related complications and neurological complications. The secondary outcomes were reduced pulmonary capillary wedge pressure, pulmonary artery pressure, central venous pressure, left atrial diameter and resolution of pulmonary oedema on a chest X-ray within 48 h.RESULTSNo death related to the LV unloading procedure was detected. Reduction in pulmonary capillary wedge pressure was highest with the TALVV technique (17.2 ± 2.1 mmHg; P &lt; 0.001) and was higher in the PBAS than in the IABP group; the difference was significant (9.6 ± 2.5 and 3.9 ± 1.3, respectively; P = 0.001). Reduction in central venous pressure with TALVV was highest with the other procedures (7.4 ± 1.1 mmHg; P &lt; 0.001). However, procedure-related complications were significantly higher with TALVV compared to the PBAS and IABP groups (50% vs 17.6% and 10%, respectively; P = 0.015). We observed no significant differences in mortality or neurological complications between the groups.CONCLUSIONSOur results suggest that TALVV was the most effective method for LV unloading compared with PBAS and IABP for VA-ECMO support but was associated with complications. Efficient LV unloading may not improve survival.
The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study
Authors: Woo K S , Chook P , Hu Y J , Lao X Q , Lin C Q , Lee PWA , Kwok CYT , Wei A N , Guo D S , Yin Y H , Lau KHA , Leung K S , Leung Y , Celermajer D S 
Published: October 2020

Abstract

Background
Air pollution has been associated with an increase in cardiovascular diseases incidence. To evaluate whether air pollution can accelerate atherogenic processes, we assessed the effects of air pollution on important surrogate markers of atherosclerosis [brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT)].

Methods
A total of 1656 Han Chinese (mean age 46.0 + 11.2 years; male 47%) in Hong Kong, Macau, Pun Yu, Yu County and the 3-Gorges Territories (Yangtze River) were studied between 1996 and 2007 [Chinese Atherosclerosis in the Aged and Young Project (the CATHAY Study)]. Cardiovascular risk profiles were evaluated. Particulate matter with an aerodynamic diameter &lt;2.5 µm (PM2.5) parameters were computed from satellite sensors. Brachial FMD and carotid IMT were measured by ultrasound.

Results
Health parameters [age, gender, body mass index, waist : hip ratio (WHR) and glucose)] were similar in lowest and highest PM2.5 exposure tertiles, systolic and diastolic blood pressures and triglycerides were higher (P &lt; 0.001) and low-density cholesterol (LDL-C) was lower in the top PM2.5 tertile (P &lt; 0.001). Brachial FMD [7.84 ± 1.77, 95% confidence interval (CI) 7.59–8.10%, vs 8.50 ± 2.52, 95% CI 8.23–8.77%, P &lt; 0.0001) was significantly lower and carotid IMT (0.68 ± 0.13 mm, 95% CI 0.67–0.69 mm vs 0.63 mm ± 0.15 mm 95% CI 0.62–0.64 mm; P &lt; 0.0001) was significantly thicker in the top PM2.5 tertile compared with the lowest tertile. On multiple regression, FMD was inversely related to PM2.5 (beta = 0.134, P = 0.015) independent of gender, age and blood pressure (model R2 = 0.156, F-value = 7.6, P &lt; 0.0001). Carotid IMT was significantly correlated with PM2.5 exposure (beta = 0.381, P &lt; 0.0001) independent of age, location, gender, WHR, blood pressure and LDL-C (model R2 = 0.408, F-value = 51.4, P-value &lt;0.0001).

Conclusions
Air pollution is strongly associated with markers of early atherosclerosis, suggesting a potential target for preventive intervention.
On the Number of Quadratic Twists with a Rational Point of Almost Minimal Height
Authors: Petit Joachim 
Published: October 2020

Abstract
We investigate the number of curves having a rational point of almost minimal height in the family of quadratic twists of a given elliptic curve. This problem takes its origin in the work of Hooley, who asked this question in the setting of real quadratic fields. In particular, he showed an asymptotic estimate for the number of such fields with almost minimal fundamental unit. Our main result establishes the analogue asymptotic formula in the setting of quadratic twists of a fixed elliptic curve.
Using evidence-based infographics to increase parents’ understanding about antibiotic use and antibiotic resistance: a proof-of-concept study
Authors: Van Hecke Oliver , Lee Joseph J , Butler Chris C , Moore Michael , Tonkin-Crine Sarah 
Published: October 2020

Abstract

Background
Communities need to see antibiotic stewardship campaigns as relevant to enhance understanding of antibiotic use and influence health-seeking behaviour. Yet, campaigns have often not sought input from the public in their development.

Objectives
To co-produce evidenced-based infographics (EBIs) about antibiotics for common childhood infections and to evaluate their effectiveness at increasing parents’ understanding of antibiotic use.

Methods
A mixed-methods study with three phases. Phase 1 identified and summarized evidence of antibiotic use for three childhood infections (sore throat, acute cough and otitis media). In phase 2, we co-designed a series of prototype EBIs with parents and a graphic design team (focus groups). Thematic analysis was used to analyse data. Phase 3 assessed the effect of EBIs on parents’ understanding of antibiotic use for the three infections using a national online survey in the UK.

Results
We iteratively co-produced 10 prototype EBIs. Parents found the evidence displayed in the EBIs novel and relevant to their families. Parents did not favour EBIs that were too medically focused. Parents preferred one health message per EBI. We included eight EBIs in a national survey of parents (n = 998). EBIs improved knowledge by more than a third across the board (34%, IQR 20%–46%, P &lt; 0.001). Respondents confirmed that EBIs were novel and potentially useful, corroborating our focus groups findings.

Conclusions
Co-designed EBIs have the potential to succinctly change parents’ perceptions about antibiotics for acute respiratory tract infections in children. Further research should test EBIs in real-world settings to assess their reach as a potential public-facing intervention.