bluuebunny/crossref_metadata_2025_split huggingface dataset:
The asylum‐process, bicultural identity and depression among unaccompanied young refugees☆
Authors: Oppedal Brit , Ramberg Visnja , Røysamb Espen 
Published: October 2020

ABSTRACTIntroductionThe overall aim of the present study was to expand our knowledge about depression among unaccompanied refugee minors in the years after they were granted protection in Norway. Predictors were contextual variables in terms of the asylum‐process, acculturation variables in terms of bicultural identity, and demographic information such as residence‐time.MethodRegister data and cross‐sectional self‐report questionnaire data were collected from 895 unaccompanied young refugees (UYRs). They originated in 31 different countries, the majority was from Afghanistan, 82.4% were boys, and average residence‐time was 2.5 years.ResultsThe length of the asylum‐process was not associated with depression while heritage identity and residence‐time were. Moderating analyses showed that an over‐time steady decrease in depression was present for UYRs with a strong heritage identity. The prevalence of depression symptoms dropped from an initial 40%–14% among youth with 10 years of residence. Majority identity had neither direct nor indirect effects on depression.ConclusionTo optimize the psychosocial support offered to unaccompanied refugee minors during transition to stable resettlement, we need more substantial information about the aspects of the asylum‐seeking process that increase the risk for mental health problems among them. In the years following resettlement, a strong heritage, but not majority identity was associated with lower levels of depressive symptoms. The findings are discussed in relation to structural barriers to bicultural identity formation and integration embedded in the way psychosocial support and education for these youths are structured, and implication for future research.
Bronchoalveolar lavage-based COVID-19 testing in patients with cancer
Authors: Abid Muhammad Bilal , Chhabra Saurabh , Buchan Blake , Graham Mary Beth , Abedin Sameem , Thapa Bicky , D’Souza Anita , George Ben , Hamadani Mehdi 
Published: October 2020

Objective/Background:
A few case reports in the setting of coronavirus disease 2019 (COVID- 19) and multiplex polymerase chain reaction (PCR)-based assays for common respiratory pathogens have shown a higher yield of bronchoalveolar lavage (BAL) samples than upper airway specimens in immunocompromised patients.

Methods:
A retrospective study was conducted reviewing patients diagnosed with COVID-19 at the Medical College of Wisconsin (Milwaukee, WI, USA) between March 13, 2020 and June 11, 2020. All patients tested positive for SARS-CoV-2 via real-time reverse transcriptase PCR (RT-PCR), through a nasopharyngeal or a bronchoscopy specimen.

Results:
During the study period, 53 bronchoscopy procedures were performed at the institution, of which five patients tested positive for COVID-19. Of the five patients, three underwent BAL testing based on high clinical suspicion for COVID-19 after the nasopharyngeal (NP) swab(s) was negative. All three patients had underlying cancers and had lymphopenia for a considerable duration prior to being diagnosed with COVID-19. Two patients had better outcomes that could be attributed to earlier BAL specimen testing resulting in timely medical intervention.

Conclusion:
This study underscores the need for early lower respiratory tract sampling, whenever possible, in patients with cancer and prolonged lymphopenia. High clinical suspicion ought to supersede false-negative NP reverse transcriptase–PCR as early bronchoscopic evaluation in cancer patients, who are either receiving active treatment or are immunosuppressed, can allow timely institution of efficacious treatment, enrollment into clinical trials, as well as effective infection control. In the apt clinical setting in patients with cancer, presumptive treatment may also be considered to minimize exposure to healthcare providers and proceduralists.
Imagining Zimbabwe as home: ethnicity, violence and migration
Authors: Ndlovu Duduzile S. 
Published: October 2020

Abstract:Migration debates tend to focus on the numbers of people moving, whether they are economic migrants or asylum seekers, deserving or not of protection. This categorization usually rests on national identity, necessitating simplified one-dimensional representations. Ndlovu uses a case study of Zimbabwean migrants memorializing Gukurahundi in Johannesburg to highlight the ways in which migration narratives can be more complex and how they may shift over time. She presents Gukurahundi and the formation of the MDC in Zimbabwe, along with xenophobic violence in South Africa, as examples of the ways that the meanings of national and ethnic identities are contested by the migrants and influenced by political events across time and space.
An elongate hadrosaurid forelimb with biological traces informs the biogeography of the Lambeosaurinae
Authors: Brownstein Chase Doran , Bissell Immanuel 
Published: October 2020

AbstractAlthough the fossil record of the Late Cretaceous eastern North American landmass Appalachia is poor compared to that from the American West, it includes material from surprisingly aberrant terrestrial vertebrates that may represent relictual forms persisting in relative isolation until the end of the Mesozoic. One intriguing question is to what extent eastern and western North American faunas interspersed following the closure of the Western Interior Seaway during the Maastrichtian Stage of the Late Cretaceous ca. 70 Ma. Isolated remains from the Atlantic Coastal Plain in New Jersey have been preliminarily identified as the bones of crested lambeosaurine hadrosaurids, a derived clade known from the Cretaceous of Asia, western North America, and Europe, but have not been formally described. We describe the partial forelimb of a large hadrosaurid from the late Maastrichtian New Egypt Formation of New Jersey. The ulna preserves multiple deep scores identifiable as shark feeding marks, and both bones show ovoid and circular marks attributable to invertebrates. This forelimb is very similar to another partial antebrachium from the same area that shows evidence of septic arthritis. Both these specimens and a complete humerus from the same unit are closely comparable to the lower forelimbs of lambeosaurines among hadrosaurid dinosaurs. Although the absence of lambeosaurine synapomorphies observable on the New Egypt Formation forelimbs precludes their definite referral to Lambeosaurinae, they show that a morphotype of large hadrosauromorph with distinctly elongate forelimbs existed in the latest Maastrichtian of eastern North America and allow for a revision of the latest Cretaceous biogeography of crested herbivorous dinosaurs.
Cretaceous–Paleogene plant extinction and recovery in Patagonia
Authors: Stiles Elena , Wilf Peter , Iglesias Ari , Gandolfo María A. , Cúneo N. Rubén 
Published: October 2020

AbstractThe Cretaceous–Paleogene (K/Pg) extinction appears to have been geographically heterogeneous for some organismal groups. Southern Hemisphere K/Pg palynological records have shown lower extinction and faster recovery than in the Northern Hemisphere, but no comparable, well-constrained Southern Hemisphere macrofloras spanning this interval had been available. Here, macrofloral turnover patterns are addressed for the first time in the Southern Hemisphere, using more than 3500 dicot leaves from the latest Cretaceous (Maastrichtian) and the earliest Paleocene (Danian) of Argentine Patagonia. A maximum ca. 90% macrofloral extinction and ca. 45% drop in rarefied species richness is estimated across the K/Pg, consistent with substantial species-level extinction and previously observed extirpation of host-specialized leaf mines. However, prior palynological and taxonomic studies indicate low turnover of higher taxa and persistence of general floral composition in the same sections. High species extinction, decreased species richness, and homogeneous Danian macrofloras across time and facies resemble patterns often observed in North America, but there are several notable differences. When compared with boundary-spanning macrofloras at similar absolute paleolatitudes (ca. 50°S or 50°N) from the Williston Basin (WB) in the Dakotas, both Maastrichtian and Danian Patagonian species richnesses are higher, extending a history of elevated South American diversity into the Maastrichtian. Despite high species turnover, our analyses also reveal continuity and expansion of leaf morphospace, including an increase in lobed and toothed species unlike the Danian WB. Thus, both Patagonian and WB K/Pg macrofloras support a significant extinction event, but they may also reflect geographically heterogeneous diversity, extinction, and recovery patterns warranting future study.
FURTHER REMARKS ON ELEMENTARY RADICALS AND ASSOCIATED FILTERS OF IDEALS
Authors: COJUHARI E. P. , GARDNER B. J. 
Published: October 2020

AbstractRyabukhin showed that there is a correspondence between elementary radical classes of rings and certain filters of ideals of the free ring on one generator, analogous to the Gabriel correspondence between torsion classes of left unital modules and certain filters of left ideals of the coefficient ring. This correspondence is further explored here. All possibilities for the intersection of the ideals in a filter are catalogued, and the connections between filters and other ways of describing elementary radical classes are investigated. Some generalisations to nonassociative rings and groups are also presented.
Optimal areas and climate change effects on dragon fruit cultivation in Mesoamerica
Authors: Sosa Victoria , Guevara Roger , Gutiérrez-Rodríguez Brandon E. , Ruiz-Domínguez Catalina 
Published: October 2020

AbstractClimbing cacti with edible fruits have been proposed as new dryland fruit crops because their high water-use efficiency reduces water requirement. One lineage of climbers in the cactus family, theHylocereusgroup ofSelenicereus, includes several species that produce edible fruits and is currently cultivated around the world. Fruits are known as pitahayas, pitayas or dragon fruit. Here, by means of ecological niche-based modelling and analytical hierarchical modelling, the optimal areas for cultivating the three main species of this group in Mesoamerica –Selenicereus costaricensis,Selenicereus ocamponisandSelenicereus undatus– are identified. Data on distribution, physiological requirement and host preferences are taken into account to carry out ecological modelling for current and future scenarios of climate and determine its impact on cultivation. Two MIROC climatic future models, one optimistic (ssp216) and a pessimistic (ssp585) were selected and 554 records from Mexico and Central America were gathered. For all three species, temperature and precipitation seasonality, and solar radiation were the most significant variables in the niche modelling. In addition, forS. undatusthe most important hosts, three species of mesquite legume trees were significant to forecast suitable areas for planting. Large areas on the Pacific side from Sinaloa to Costa Rica were predicted as favourable for cultivating the studied three species. Future scenarios of climate change predicted increase of suitable areas for two species and in particular forS. undatusthe increment was the largest. Therefore, dragon fruits are corroborated as promising fruits in view of climate change.
Combined pigment and metatranscriptomic analysis reveals highly synchronized diel patterns of phenotypic light response across domains in the open oligotrophic ocean
Authors: Becker Kevin W , Harke Matthew J , Mende Daniel R , Muratore Daniel , Weitz Joshua S , DeLong Edward F , Dyhrman Sonya T , Van Mooy Benjamin A S 
Published: October 2020

AbstractSunlight is the most important environmental control on diel fluctuations in phytoplankton activity, and understanding diel microbial processes is essential to the study of oceanic biogeochemical cycles. Yet, little is known about the in situ temporal dynamics of phytoplankton metabolic activities and their coordination across different populations. We investigated diel orchestration of phytoplankton activity in photosynthesis, photoacclimation, and photoprotection by analyzing pigment and quinone distributions in combination with metatranscriptomes in surface waters of the North Pacific Subtropical Gyre (NPSG). We found diel cycles in pigment abundances resulting from the balance of their synthesis and consumption. These dynamics suggest that night represents a metabolic recovery phase, refilling cellular pigment stores, while photosystems are remodeled towards photoprotection during daytime. Transcript levels of genes involved in photosynthesis and pigment metabolism had synchronized diel expression patterns among all taxa, reflecting the driving force light imparts upon photosynthetic organisms in the ocean, while other environmental factors drive niche differentiation. For instance, observed decoupling of diel oscillations in transcripts and related pigments indicates that pigment abundances are modulated by environmental factors extending beyond gene expression/regulation reinforcing the need to combine metatranscriptomics with proteomics and metabolomics to fully understand the timing of these critical processes in situ.
RETRACTED ARTICLE: LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53
Authors: Zhao Wenjing , Jin Yan , Wu Peng , Yang Jian , Chen Yuanyuan , Yang Qianlu , Huo Xinying , Li Juxue , De Wei , Chen Jinfei , Yang Fen 
Published: October 2020

AbstractLong noncoding RNAs (LncRNAs) have been reported to play critical roles in gastric cancer, but true biomarkers remain unknown. In this study, we found a new lncRNA LINC00355 that was involved in malignant progression of gastric cancer (GC) and further revealed its role and mechanism. Differentially expressed lncRNAs were identified through bioinformatics, and qRT-PCR was used to validate the expression of LINC00355 in gastric cancer tissues and cells. The biological role of LINC00355 in GC was detected by gene overexpression and knockdown experiments. Subcellular fractionation, qRT-PCR, and FISH were performed to detect the subcellular localization. Co-IP and western blotting were used to study the ubiquitination-mediated regulation of P53 and the expression of the E3 ligases RAD18 and UBE3C. The results showed that LINC00355 was significantly increased in gastric cancer cell lines and patient tissues and closely correlated with late stages, distant metastasis, and poor prognosis of patients. High expression of LINC00355 promoted the proliferation and invasion of gastric cancer cells in vivo and in vitro. Mechanistic studies found that LINC00355 that mainly located in the nucleus, acting as a transcriptional activator, promoted transcription of RAD18 and UBE3C, which both bind to P53 and mediate the ubiquitination and degradation of P53. Furthermore, LINC00355 overexpression enhanced the ubiquitination process, and LINC00355 knockdown alleviated it. These results indicated that LINC00355 induces gastric cancer cell proliferation and invasion by promoting transcription of RAD18 and UBE3C, which mediates ubiquitination of P53 and thereby plays a critical role in survival and tumorigenicity of gastric cancer cells. LINC00355 may represent a new mechanism for GC progression and provide a potential marker for GC diagnosis and treatment.
Gold, silver or bronze: circadian variation strongly affects performance in Olympic athletes
Authors: Lok R. , Zerbini G. , Gordijn M. C. M. , Beersma D. G. M. , Hut R. A. 
Published: October 2020

AbstractThe circadian system affects physiological, psychological, and molecular mechanisms in the body, resulting in varying physical performance over the day. The timing and relative size of these effects are important for optimizing sport performance. In this study, Olympic swim times (from 2004 to 2016) were used to determine time-of-day and circadian effects under maximal motivational conditions. Data of athletes who made it to the finals (N = 144, 72 female) were included and normalized on individual levels based on the average swim times over race types (heat, semifinal, and final) per individual for each stroke, distance and Olympic venue. Normalized swim times were analyzed with a linear mixed model and a sine fitted model. Swim performance was better during finals as compared to semi-finals and heats. Performance was strongly affected by time-of-day, showing fastest swim times in the late afternoon around 17:12 h, indicating 0.32% improved performance relative to 08:00 h. This study reveals clear effects of time-of-day on physical performance in Olympic athletes. The time-of-day effect is large, and exceeds the time difference between gold and silver medal in 40%, silver and bronze medal in 64%, and bronze or no medal in 61% of the finals.
Non-enzymatic sensor for determination of glucose based on PtNi nanoparticles decorated graphene
Authors: Li Risheng , Deng Xu , Xia Longfei 
Published: October 2020

AbstractDiabetes has become a universal epidemic in recent years. Herein, the monitoring of glucose in blood is of importance in clinical applications. In this work, PtNi alloy nanoparticles homogeneously dispersed on graphene (PtNi alloy-graphene) was synthesized as a highly effective electrode material for glucose detection. Based on the modified PtNi alloy-graphene/glass carbon (PtNi alloy-graphene/GC) electrode, it is found that the PtNi alloy-graphene/GC electrode exhibited excellent electrocatalytic performance on glucose oxidation. Furthermore, the results from amperometric current–time curve show a good linear range of 0.5–15 mM with the limit of detection of 16 uM (S/N = 3) and a high sensitivity of 24.03 uAmM−1 cm−2. On account of the good selectivity and durability, the modified electrode was successfully applied on glucose detection in blood serum samples.
Spatial analysis of hepatobiliary abnormalities in a population at high-risk of cholangiocarcinoma in Thailand
Authors: Thinkhamrop Kavin , Suwannatrai Apiporn T. , Chamadol Nittaya , Khuntikeo Narong , Thinkhamrop Bandit , Sarakarn Pongdech , Gray Darren J. , Wangdi Kinley , Clements Archie C. A. , Kelly Matthew 
Published: October 2020

AbstractCholangiocarcinoma (CCA) is a serious health challenge with low survival prognosis. The liver fluke, Opisthorchis viverrini, plays a role in the aetiology of CCA, through hepatobiliary abnormalities: liver mass (LM), bile duct dilation, and periductal fibrosis (PDF). A population-based CCA screening program, the Cholangiocarcinoma Screening and Care Program, operates in Northeast Thailand. Hepatobiliary abnormalities were identified through ultrasonography. A multivariate zero-inflated, Poisson regression model measured associations between hepatobiliary abnormalities and covariates including age, sex, distance to water resource, and history of O. viverrini infection. Geographic distribution was described using Bayesian spatial analysis methods. Hepatobiliary abnormality prevalence was 38.7%; highest in males aged > 60 years (39.8%). PDF was most prevalent (20.1% of males). The Standardized Morbidity Ratio (SMR) for hepatobiliary abnormalities was highest in the lower and upper parts of the Northeast region. Hepatobiliary abnormalities specifically associated with CCA were also more common in males and those aged over 60 years and distributed along the Chi, Mun, and Songkram Rivers. Our findings demonstrated a high risk of hepatobiliary disorders in Northeast Thailand, likely associated with infection caused by O. viverrini. Screening for CCA and improvement of healthcare facilities to provide better treatment for CCA patients should be prioritized in these high-risk areas.
Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera
Authors: Kiyota Yasuhiro , Muramatsu Hiroyasu , Sato Yuiko , Kobayashi Tami , Miyamoto Kana , Iwamoto Takuji , Matsumoto Morio , Nakamura Masaya , Tateno Hiroki , Sato Kazuki , Miyamoto Takeshi 
Published: October 2020

AbstractSmoking is thought to be a risk factor for osteoporosis development; however, the consequences of stopping smoking for bone homeostasis remain unknown. Here we conducted two separate human studies and show that bone mineral density was significantly lower in smokers than in non-smokers. The first was an observational study of pre- and post-menopausal healthy female smokers and non-smokers; the second included 139 current smokers determined to stop smoking. In the second study, levels of bone formation markers such as osteocalcin and uncarboxylated osteocalcin significantly increased after successful smoking cessation, as verified by significantly reduced levels of serum cotinine, a nicotine metabolite. Moreover, nicotine administration to mice reduced bone mineral density and significantly increased the number of osteoclasts in bone. Reduced bone mass phenotypes seen in nicotine-treated mice were significantly increased following nicotine withdrawal, an outcome accompanied by significantly reduced serum levels of tartrate-resistant acid phosphatase, a bone resorption marker. Taken together, our findings suggest that bone homeostasis is perturbed but can be rescued by smoking cessation.
Laser wakefield accelerated electron beams and betatron radiation from multijet gas targets
Authors: Tomkus Vidmantas , Girdauskas Valdas , Dudutis Juozas , Gečys Paulius , Stankevič Valdemar , Račiukaitis Gediminas , Gallardo González Isabel , Guénot Diego , Svensson Jonas Björklund , Persson Anders , Lundh Olle 
Published: October 2020

AbstractLaser Plasma Wakefield Accelerated (LWFA) electron beams and efficiency of betatron X-ray sources is studied using laser micromachined supersonic gas jet nozzle arrays. Separate sections of the target are used for the injection, acceleration and enhancement of electron oscillation. In this report, we present the results of LWFA and X-ray generation using dynamic gas density grid built by shock-waves of colliding jets. The experiment was done with the 40 TW, 35 fs laser at the Lund Laser Centre. Electron energies of 30–150 MeV and 1.0 × 108–5.5 × 108 photons per shot of betatron radiation have been measured. The implementation of the betatron source with separate regions of LWFA and plasma density grid raised the efficiency of X-ray generation and increased the number of photons per shot by a factor of 2–3 relative to a single-jet gas target source.