bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of SOX18 expression in nonmelanoma skin cancers for prediction of high‐risk patients: a preliminary study
Authors: Neinaa Yomna Mazid El‐Hamd , El‐Ashmawy Amal Ahmad , Alshenawy Hanan Al‐Saeid , Arakeeb Enas Elsaid Ahmed 
Published: July 2020

AbstractBackgroundSOX18 is an integral transcription factor that is involved in endothelial cells differentiation during both angiogenesis and lymphangiogenesis. Therefore, it has been implicated in tumor progression and metastasis.ObjectiveTo study SOX18 expression in nonmelanoma skin cancers (NMSCs) in comparison to seborrheic keratosis (SK) and normal control skin, and to assess its probable role in tumor evolution and progression.Patients and MethodsThis study was conducted on 60 specimens of NMSCs: 30 basal cell carcinomas (BCC) and 30 squamous cell carcinomas (SCC), 30 specimens of SK, and 30 normal skin specimens. All were examined for immunohistochemical expression of SOX18 antibody. Additionally, morphometric assessment of vessel density (blood & lymphatic) in each specimen was estimated.ResultsSignificant SOX18 overexpression was observed in all studied cutaneous tumors in comparison to control skin. The highest score of SOX18 expression was detected in SCC, then BCC, and the least expression was reported in SK with significant difference between them. Furthermore, significant upregulation of SOX18 expression was observed in high‐risk types of both BCC and SCC compared to low‐risk types. Stromal vessel density showed significant differences between the studied tumors with the highest mean value in SCC, followed by BCC and then SK. Positive correlation between SOX18 expression in the studied tumors and their vessel density was detected.ConclusionsSOX18 may have a potential role in the evolution as well as progression of NMSCs, possibly through induction of both angiogenesis and lymphangiogenesis. Furthermore, it could be beneficial for prediction of NMSC patients with poor prognosis.
Considerations for the use of gonadotropin‐releasing hormone agonists and antagonists in patients with prostate cancer
Authors: Van Poppel Hendrik , Abrahamsson Per‐Anders 
Published: July 2020

AbstractProstate cancer is the second most common cause of cancer‐related deaths in men, representing a major source of morbidity and mortality. Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at disease presentation, which can be achieved either with surgical or chemical castration. The development of gonadotropin‐releasing hormone agonists revolutionized the treatment of advanced prostate cancer, replacing the need for surgical castration. Agonists downregulate gonadotropin‐releasing hormone agonist receptors in the pituitary gland, and thus decrease the release of luteinizing hormone and testosterone. Although agonists are a common therapeutic option to date, their use is associated with testosterone surges, metabolic dysfunction and an increase in the risk of cardiovascular disease; they might contribute to tumor flares and potentially an increase in non‐cancer mortality. More recently, gonadotropin‐releasing hormone antagonists have entered the prostate cancer treatment landscape. Unlike agonists, antagonists directly inhibit the androgen receptor in the pituitary gland, and thus do not cause initial testosterone surges. In this article, we provide a concise review of the mechanism of actions, safety and efficacy of the approved agonists and antagonists for prostate cancer treatment.
Trends in burn injuries in Galicia (Spain): An epidemiological study
Authors: Palacios García Pablo , Pacheco Compaña Francisco Javier , Rodríguez Pérez Esther , Bugallo Sanz Juan Ignacio , Fernández‐Quinto Alejandro , Avellaneda‐Oviedo Edgar Mauricio 
Published: July 2020

AbstractThe treatment of burns is one of the earliest medical activities on record, probably because of the powerful impact of their physical consequences among other sequelae. The aim of the present paper is to perform an epidemiological study of burn patients. The data were obtained by reviewing the medical histories of all those patients admitted or treated in the Outpatients Department of the Burn Unit of our hospital between 2013 and 2017. A sample was gathered of 1401 patients, made up of 716 males (51.11%) and 685 females (48.89%), in a ratio of males to females of 1.05, with a mean age of 40.74 years old. The burns were mainly suffered in a domestic setting (60.96%), mostly as a result of contact with hot liquids. Most of the burns were second degree superficial burns (60.03%), and affected a mean total body surface area (TBSA) of 4.61%. They were most often produced on the hands. It was found that the frequency of burns increased during the summer and during the main mealtimes of the day. These data may be used to make specific plans of prevention, and as a basis for new studies and databases to be made.
Complete clearance and psoriasis area and severity index response for brodalumab and ustekinumab in AMAGINE‐2 and ‐3
Authors: Warren R.B. , Hansen J.B. , Reich K. , Paul C. , Puig L. 
Published: July 2020

AbstractBackgroundModern biologics achieve complete skin clearance [100% improvement in psoriasis area and severity index (PASI 100)] in 30–45% of psoriasis patients. Cumulative benefit considering rapidity, frequency and sustainability of response has not been thoroughly investigated.ObjectivesCompare the frequency, rapidity and sustainability of PASI 90 and 100 response in patients with moderate‐to‐severe psoriasis treated with brodalumab or ustekinumab.MethodsIntegrated analyses of the brodalumab Phase III AMAGINE‐2 (NCT01708603) and ‐3 (NCT01708629) trials were performed to determine proportion of patients achieving PASI response per visit; corresponding odds ratios (OR) were calculated. Cumulative clinical benefit of treatment was determined with area‐under‐the‐curve (AUC) analysis. Cumulative incidence of response was analysed using a competing risk model of PASI response or rescue. Sustained response was evaluated by time to inadequate response using Kaplan–Meier methods. Proportion of time spent in different response states was descriptively analysed. Association between PASI response and health‐related quality of life [Dermatology Life Quality Index (DLQI)] was assessed using data from all treatment groups from AMAGINE‐1, ‐2 and ‐3.ResultsA significantly higher proportion of patients treated with brodalumab achieved PASI 100 vs. ustekinumab (Week 52: 51% vs. 28%; OR [95% CI] 2.8 [2.1, 3.7]; P < 0.0001), with significant differences observed from Week 4. Cumulative benefit through 52 weeks was 69% higher with brodalumab (AUC ratio: 1.69; P < 0.001). Brodalumab patients were also significantly more likely to achieve a PASI 100 at least once over 52 weeks vs. ustekinumab (76% vs. 52%; P < 0.0001). Once response was achieved, brodalumab patients had a low likelihood of failure or need for rescue. There was significant positive association between PASI response level and DLQI0/1 achievement (P < 0.0001).ConclusionBrodalumab treatment resulted in significantly higher levels of skin clearance, longer sustained response and greater cumulative treatment benefit vs. ustekinumab.
Fluctuating environments impact thermal tolerance in an invasive insect species Bactrocera dorsalis (Diptera: Tephritidae)
Authors: Mutamiswa Reyard , Tarusikirwa Vimbai , Nyamukondiwa Casper , Chidawanyika Frank 
Published: July 2020

AbstractThe incidence and severity of environmental stressors associated with global climate change are increasing and insects frequently face variability in temperature and moisture regimes at variable spatio‐temporal scales. Coincidental with this, is increased thermal and hydric stress on insects as warming increases vapour pressure deficit (VPD), the drying power of the air. While the effects of mean temperatures on fitness are widely documented, fluctuations in both temperature and relative humidity (RH) are largely unexplored. Here, we investigated the effects of dynamic temperature and RH fluctuations (around the mean [28°C; 65% RH]) on low and high thermal tolerance of laboratory‐reared adult invasive Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), measured as critical thermal minima (CTmin), critical thermal maxima (CTmax), chill coma recovery time (CCRT) and heat knockdown time (HKDT). Our results show that increased environmental amplitude significantly influenced low and high temperature responses and varied across traits tested. The highest amplitude (δ12°C; 28% RH) compromised CTmin, CCRT and HKDT traits while enhancing CTmax. Similarly, acclimation to δ3°C; 7% RH compromised both low (CTmin and CCRT) and high (CTmax and HKDT) fitness traits. Variations in fitness reported here indicate significant roles of combined thermal and moisture fluctuations on B. dorsalis fitness suggesting caveats that are worthy considering when predicting species responses to climate change. These results are significant for B. dorsalis population phenology, management, quantifying vulnerability to climate variability and may help modelling future biogeographical patterns.
New salmonid hosts for Tenacibaculum species: Expansion of tenacibaculosis in Chilean aquaculture
Authors: Avendaño‐Herrera Ruben , Collarte Constanza , Saldarriaga‐Córdoba Mónica , Irgang Rute 
Published: July 2020

AbstractThe success and sustainability of Chilean aquaculture largely depends on the control of endemic and emerging pathogens, including several species of the genus Tenacibaculum. Tenacibaculum dicentrarchi and “Tenacibaculum finnmarkense” have been detected and confirmed in Chilean Atlantic salmon (Salmo salar). However, no outbreaks of tenacibaculosis in rainbow trout (Oncorhynchus mykiss) or coho salmon (Oncorhynchus kisutch) have been reported, either in Chile or globally. The aims of this study were to determine whether the mortalities recorded for rainbow trout and coho salmon from five marine fish farms located in the Los Lagos, Aysén, and Magallanes Regions could be caused by Tenacibaculum spp. The diseased fish exhibited cutaneous haemorrhages, tail and peduncle rots, and damage on the mouth and tongue. Microbiological analysis of infected external tissues yielded 13 bacterial isolates. The isolates were identified as members of the genus Tenacibaculum through biochemical analysis (e.g. Gram‐stain negative, straight rods, filamentous cells and motile by gliding), but differences existed in biochemical results, making species‐level identification through biomolecular tools essential. The 16S rRNA analysis found that the majority of isolates were more closely related to “T. finnmarkense” than T. dicentrarchi, while the phylogenetic trees resulting from multilocus sequence data recovered the four main clades (clades I to IV) identified by Olsen et al. (2017, Veterinary Microbiology, 205, 39). This is the first documented occurrence of clinical tenacibaculosis in farmed rainbow trout and coho salmon globally, and it extends the known host distribution of this pathogen in Chile. Moreover, we confirm the presence of Tenacibaculum species in the Chilean Patagonia. These findings highlight the importance of establishing preventative measures to minimize the spread of this disease within the Chilean marine aquaculture industry, as well as the need for monitoring initiatives worldwide in these farmed fish species.
Thermophysical properties of carbohydrate solutions: Correlation between thermal and transport properties
Authors: Martins Maria Júlia Neves , Guimarães Bianca , Polachini Tiago Carregari , Telis‐Romero Javier 
Published: July 2020

AbstractSugar solutions such as sucrose, glucose and fructose are often used in osmotic dehydration processes. Thus, the experimental determination of their thermophysical properties is a must for designing purposes. Density, specific heat and thermal conductivity were determined in a wide range of solute concentration (10–60 °Brix) and temperature (273.15–358.15 K). Empirical equations were considered to fit the experimental data and to evaluate the data behavior. An assessment based on the Prandtl number was considered to correlate thermal and rheological data. Higher density and lower specific heat and thermal conductivity values were observed when temperature decreased and solute concentration increased. Prandtl number behaved similarly as density, indicating that momentum transfer is favored in comparison with heat transfer in more concentrated solutions at lower temperatures. A versatile polynomial model concerning the significant variables could predict the experimental values for all solutions with good accuracy (R2 > .9863 and MRE < 1.20%). Reported data and equations showed to be essential for engineering aspects and transport phenomena analysis.Practical ApplicationsSucrose, glucose and fructose solutions are commonly used in osmotic dehydration processes to promote solute incorporation, increasing shelf‐life and quality of food products. The availability of thermophysical properties in a wide range of solute concentration and temperature covers the most of conventional and nonconventional conditions for designing osmotic dehydration and many other food processes. Among the unit operations, it could be found pumping, mixing/stirring, pasteurization, sterilization, evaporation and so on. These data are useful to understand how properties change when the conditions are altered during the processes. They also provide important information about momentum and heat transfer through the fluid. By analyzing dimensionless parameters, as Prandtl number, one phenomenon or other can be favored under specific conditions. The presence of accurate mathematical models results in greater agility and reliability in the execution of processes, especially for those operating in wide ranges of temperature and solute concentration.
Clinical validation of the temporal lifting technique using soft tissue fillers
Authors: Hernandez Claudia A. , Freytag David L. , Gold Michael H. , Pavicic Tajana , Ascher Benjamin , de Almeida Ada Trindade , Green Jeremy B. , Fabi Sabrina G. , Frank Konstantin , Cotofana Sebastian 
Published: July 2020

AbstractBackgroundWhile the temporal lifting technique has gained increasing attention, there is a dearth of objective and reliable evidence of its effects.AimThe objective of the present study is to analyze the ability of the temporal lifting technique to reduce the midfacial volume by soft tissue repositioning and to achieve an improved pan‐facial appearance by targeting exclusively the subdermal plane of the posterior and superior temple with soft tissue fillers.MethodsA total of 12 patients (1 male and 11 females) with a mean age of 36.75 ± 6.6 years and a mean body mass index of 23.04 ± 1.3 kg/m2 were included in this prospective clinical single‐center interventional study. Injection‐related outcome was evaluated utilizing 3D skin vector displacement and surface volume analyses and scoring based on five different evaluators.ResultsThree months after the treatment, the global esthetic improvement scale rating showed an improved outcome (3.08) when evaluated by the independent observers, very improved outcome when evaluated by the treating physician (4.33), and exceptional improvement when rated by the patient (4.83). Temporal volume improved by 0.36 (P < .001), lower cheek fullness by 0.47 (P < .001), and jawline contouring by 0.51 (P < .001). No major adverse events were reported during the 3‐month observational period.ConclusionObjective outcome measures have provided evidence that by augmenting the posterior superior temple the volume of the middle face can be reduced and the contour of the jawline can be accentuated; this is due to the underlying fascial anatomy and the resulting soft tissue re‐position.
LsGRP1, a class II glycine‐rich protein of Lilium, confers plant resistance via mediating innate immune activation and inducing fungal programmed cell death
Authors: Lin Chia‐Hua , Pan Ying‐Chieh , Ye Nai‐Hua , Shih Yu‐Ting , Liu Fan‐Wei , Chen Chao‐Ying 
Published: July 2020

AbstractDefence‐related LsGRP1 is a leaf‐specific plant class II glycine‐rich protein (GRP) involved in salicylic acid‐induced systemic resistance against grey mould caused by necrotrophic Botrytis elliptica in lily (Lilium) cultivar Stargazer. The C‐terminal region of LsGRP1 (LsGRP1C) can inhibit fungal growth in vitro via a mechanism of inducing fungal apoptosis programmed cell death (PCD). In this study, the role of LsGRP1 in induced defence mechanism was investigated using LsGRP1‐silenced Stargazer lily and LsGRP1‐transgenic Arabidopsis thaliana. LsGRP1 silencing in lily was found to slightly inhibit plant growth and greatly increase the susceptibility to B. elliptica by suppressing callose deposition and early reactive oxygen species (ROS) accumulation. In contrast, LsGRP1‐transgenic Arabidopsis showed higher resistance to Botrytis cinerea and also to Pseudomonas syringae pv. tomato DC3000 as compared to the wild type, accompanied with the enhancement of callose deposition and ROS accumulation. Additionally, LsGRP1 silencing increased plant cell death caused by B. elliptica secretion and reduced pathogen‐associated molecular pattern (PAMP)‐triggered defence activation in Stargazer lily. Consistently, LsGRP1 expression boosted PAMP‐triggered defence responses and effector recognition‐induced hypersensitive response in Arabidopsis. Moreover, fungal apoptosis PCD triggered by LsGRP1 in an LsGRP1C‐dependent manner was demonstrated by leaf infiltration with LsGRP1C‐containing recombinant proteins in Stargazer lily. Based on these results, we presume that LsGRP1 plays roles in plant defence via functioning as a pathogen‐inducible switch for plant innate immune activation and acting as a fungal apoptosis PCD inducer to combat pathogen attack.
The necessity and possibilities of playfulness in narrative care with older adults
Authors: Blix Bodil H. , Berendonk Charlotte , Clandinin D. Jean , Caine Vera 
Published: July 2020

AbstractFor us, narrative care is grounded in pragmatist philosophy and focused on experience. Narrative care is not merely about acknowledging or listening to people's experiences, but draws attention to practical consequences. We conceptualize care itself as an intrinsically narrative endeavour. In this article, we build on Lugones' understanding of playfulness, particularly to her call to remain attentive to a sense of uncertainty, and an openness to surprise. Playfulness cultivates a generative sense of curiosity that relies on a close attentiveness not only to the other, but to who we each are within relational spaces. Generative curiosity is only possible if we remain playful as we engage and think with experiences and if we remain responsive to the other. Through playfulness, we resist dominant narratives and hold open relational spaces that create opportunities of retelling and reliving our experiences. Drawing on our work alongside older adults, as well as people who work in long‐term care, we show the possibilities of playfulness in the co‐composition of stories across time. By intentionally integrating playfulness, narrative care can be seen as an intervention, as well as a human activity, across diverse social contexts, places and times.
Violence versus gratitude: Courses of recognition in caring situations
Authors: Manara Duilio F. , Giannetta Noemi , Villa Giulia 
Published: July 2020

AbstractPandemic infection by COVID‐19 could be changing the public image of the nursing profession in Italy. Recently, as in any western country, we were being registered with an increase in the number of violence against healthcare professionals. Nevertheless, due to pandemic in the social media, the nursing profession is remembered for competence, determination, courage, and humanity, and it is continually remercied by people, politicians, and journalists. In this paper, we will conduct a phenomenological argument that proposes both phenomena can be explained by Paul Ricoeur's courses of recognition. In cases of violence, patients and their family members reacting because they feel betrayed for a real or alleged injustice—primarily not to be listened to by health professionals. Nurses and other professionals are often unable to take the right grade of involvement for understanding patient's needs. On the other hand, during COVID‐19 pandemic, patients and family members perceive the extraordinary daily work of caring, and they react thanking. The principle of the gift is implicated in both cases: the crisis of gift received or donated can be explaining violence; gratitude and thanks can be explaining by gratuitousness of care.
The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review
Authors: Saeidi Ayoub , Haghighi Marjan Mosalman , Kolahdouzi Sarkawt , Daraei Ali , Abderrahmane Abderraouf Ben , Essop M. Faadiel , Laher Ismail , Hackney Anthony C. , Zouhal Hassane 
Published: July 2020

SummaryThis narrative review summarizes current knowledge on the effects of physical activity (PA) on adipokine levels in individuals with overweight and obesity. Approximately 90 investigations including randomized control, cross‐sectional and longitudinal studies that reported on the effects of a single session of PA (acute) or long‐term PA (chronic) on adipokine levels in individuals with overweight/obesity were reviewed. The findings support the notion that there is consensus on the benefits of chronic exercise training—regardless of the mode (resistance vs. aerobic), intensity and cohort (healthy vs. diabetes)—on adipokine levels (such as tumour necrosis factor‐alpha, interleukin‐6, adiponectin, visfatin, omentin‐1 and leptin). However, several confounding factors (frequency, intensity, time and type of exercise) can alter the magnitude of the effects of an acute exercise session. Available evidence suggests that PA, as a part of routine lifestyle behaviour, improves obesity complications by modulating adipokine levels. However, additional research is needed to help identify the most effective interventions to elicit the most beneficial changes in adipokine levels in individuals with overweight/obesity.
COMMERCIAL AND SOCIAL SIGNIFICANCE OF GLASS BEADS IN MIGRATION‐PERIOD ITALY: THE CEMETERY OF CAMPO MARCHIONE
Authors: Boschetti Cristina , Gratuze Bernard , Schibille Nadine 
Published: July 2020

SummaryMigration‐period glass beads from Italy are an overlooked source of evidence. This investigation discusses the provenance, economic value and social significance of glass beads from the cemetery of Campo Marchione, northern Italy (c.570 to the end of the seventh century AD). The different chemical compositions and specific forming technologies have identified European, Egyptian, Mesopotamian and Asian specimens. The wider contextualization of the beads in association with other grave goods and the sex and age of the deceased has yielded important insights into the economic, social and cultural significance beads held in Italy, acting as markers of long‐distance exchange.