bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectroscopic long-term monitoring of RZ Cas
Authors: Lehmann H. , Dervişoğlu A. , Mkrtichian D. E. , Pertermann F. , Tkachenko A. , Tsymbal V. 
Published: November 2020

Context. RZ Cas is a short-period Algol-type system showing episodes of mass transfer and δ Sct-like oscillations of its mass-gaining primary component. This system exhibits temporal changes in orbital period, v sin i, and the oscillation pattern of the primary component.
Aims. We analyse high-resolution spectra of RZ Cas that we obtained during a spectroscopic long-term monitoring lasting from 2001 to 2017. In this first part we investigate the atmospheric parameters of the stellar components and the time variation of orbital period, v sin i, and radial velocities (RVs), searching for seasonal changes that could be related to episodes of mass exchange and to a possible activity cycle of the system triggered by the magnetic cycle of the cool companion.
Methods. We used spectrum synthesis to analyse the spectra of both components of RZ Cas. The study of variations of the orbital period is based on published times of primary minima. We used the least-squares deconvolved (LSD) binary program to derive separated RVs and LSD profiles of the components. From the LSD profiles of the primary we determined its v sin i. Using Markov chain Monte Carlo simulations with the PHOEBE program, we modelled the RV variations of both components.
Results. Spectrum analysis resulted in precise atmospheric parameters of both components, in particular in surface abundances below solar values. We find that the variation of orbital period is semi-regular and derive different characteristic timescales for different epochs of observation. We show that the RV variations with orbital phase can be modelled when including two cool spots on the surface of the secondary component. The modelling leads to very precise masses and separation of the components. The seasonal variation of several parameters, such as v sin i, rotation-orbit synchronisation factor, strength of the spots on the cool companion, and orbital period, can be characterised by a common timescale of the order of nine years.
Conclusions. We interpret the timescale of nine years as the magnetic activity cycle of the cool companion. In particular the behaviour of the dark spots on the cool companion leads us to the interpretation that this timescale is based on an 18-yr magnetic dynamo cycle. We conclude that the mass-transfer rate is controlled by the variable depth of the Wilson depression in the magnetic spot around the Lagrangian point L1. In the result, based on available data, we observe a damped activity cycle of the star, starting with a high mass-transfer episode around 2001 with a calculated mass-transfer rate of 1.510−6 M⊙ yr−1, followed by quiet periods in 2006 and 2009, slightly higher activity around 2013 and 2014, and again followed by quiet periods in 2015 and 2016. However, owing to missing data for years 2010 and 2011, we cannot exclude that a second high mass-transfer episode occurred within this time span.
Tile-in-One: an integrated system for data quality and condition assessment for the ATLAS Tile Calorimeter
Authors: Smirnov Yuri , Smieško Juraj 
Published: November 2020

The Tile Calorimeter (TileCal) is a crucial part of the ATLAS detector, which jointly with other calorimeters reconstructs hadrons, jets, tau-particles, missing transverse energy and assists in muon identification. It consists of alternating steel absorber layers and active scintillating tiles and covers the region |η| < 1.7. The TileCal is regularly monitored by several systems, which were developed mainly during the commissioning of the detector in order to meet distinct requirements. Any problem is reported and immediately investigated, which results in data quality efficiency very close to 100%, as achieved over the last few years. Although the TileCal tools are maintained, the underlying technologies are becoming gradually outdated.
The Tile-in-One web platform strives to integrate all data quality and condition assessment TileCal tools into one common system. This system is implemented as a web application with the main machine being the gateway for so-called plugins. These are standalone small web application hosted on a single virtual machine. The plugins are separated into virtual machines due to the requirement of different data sources and to avoid interference in order to increase the stability of the platform. The main server is responsible for the authentication and authorization of the users, as well as the management of the plugins. Currently the platform consists of 13 plugins in various stages of development. The implementation details of the Tile-in-One web system and selected plugins are presented in this document.
Highly Performant, Deep Neural Networks with sub-microsecond latency on FPGAs for Trigger Applications
Authors: Nottbeck Noel , Schmitt Christian , Büscher Volker 
Published: November 2020

Artificial neural networks are becoming a standard tool for data analysis, but their potential remains yet to be widely used for hardware-level trigger applications. Nowadays, high-end FPGAs, often used in low-level hardware triggers, offer theoretically enough performance to include networks of considerable size. This makes it very promising and rewarding to optimize a neural network implementation for FPGAs in the trigger context.
Here an optimized neural network implementation framework is presented, which typically reaches 90 to 100% computational efficiency, requires few extra FPGA resources for data flow and controlling, and allows latencies in the order of 10s to few 100s of nanoseconds for entire (deep) networks.
CRIC: Computing Resource Information Catalogue as a unified topology system for a large scale, heterogeneous and dynamic computing infrastructure
Authors: Anisenkov Alexey , Andreeva Julia , Di Girolamo Alessandro , Paparrigopoulos Panos , Vasilev Boris 
Published: November 2020

CRIC is a high-level information system which provides flexible, reliable and complete topology and configuration description for a large scale distributed heterogeneous computing infrastructure. CRIC aims to facilitate distributed computing operations for the LHC experiments and consolidate WLCG topology information. It aggregates information coming from various low-level information sources and complements topology description with experimentspecific data structures and settings required by the LHC VOs in order to exploit computing resources.
Being an experiment-oriented but still experiment-independent information middleware, CRIC offers a generic solution, in the form of a suitable framework with appropriate interfaces implemented, which can be successfully applied on the global WLCG level or at the level of a particular LHC experiment. For example there are CRIC instances for CMS[11] and ATLAS[10]. CRIC can even be used for a special task. For example, a dedicated CRIC instance has been built to support transfer tests performed by DOMA Third Party Copy working group. Moreover, extensibility and flexibility of the system allow CRIC to follow technology evolution and easily implement concepts required to describe new types of computing and storage resources.
The contribution describes the overall CRIC architecture, the plug-in based implementation of the CRIC components as well as recent developments and future plans.
An ARM cluster for running CMSSW jobs
Authors: Osmani Lirim , Lindén Tomas 
Published: November 2020

The ARM platform extends from the mobile phone area to development board computers and servers. It could be that in the future the importance of the ARM platform will increase for High Performance Computing/High Throughput Computing (HPC/HTC) if new more powerful (server) boards are released. For this reason Compact Muon Solenoid Software (CMSSW) has previously been ported to ARM in earlier work.
The CMSSW is deployed using the CERN Virtual Machine File System (CVMFS) and the jobs are run inside Singularity containers. Some ARM AArch64 CMSSW releases are available in CVMFS for testing and development. In this work CVMFS and Singularity have been compiled and installed on an ARM cluster and the AArch64 CMSSW releases in CVMFS have been used. We report on our experiences with this ARM cluster for CMSSW jobs.
Commodity hardware designed around the 64-bit architecture has been the basis of current virtualization trends with the advantage to emulate diverse environments for a wide range of computational scenarios. However, in parallel the mobile revolution have given a rise to ARM SoCs with primary focus on power efficiency. While still in the experimental phase, the power efficiency and 64-bit heterogeneous computing already point to an alternative option for traditional x86_64 CPUs servers for datacenters.
Extension of the INFN Tier-1 on a HPC system
Authors: Boccali Tommaso , Dal Pra Stefano , Spiga Daniele , Ciangottini Diego , Zani Stefano , Bozzi Concezio , De Salvo Alessandro , Valassi Andrea , Noferini Francesco , dell’Agnello Luca , Stagni Federico , Doria Alessandra , Bonacorsi Daniele 
Published: November 2020

The INFN Tier-1 located at CNAF in Bologna (Italy) is a center of the WLCG e-Infrastructure, supporting the 4 major LHC collaborations and more than 30 other INFN-related experiments.
After multiple tests towards elastic expansion of CNAF compute power via Cloud resources (provided by Azure, Aruba and in the framework of the HNSciCloud project), and building on the experience gained with the production quality extension of the Tier-1 farm on remote owned sites, the CNAF team, in collaboration with experts from the ALICE, ATLAS, CMS, and LHCb experiments, has been working to put in production a solution of an integrated HTC+HPC system with the PRACE CINECA center, located nearby Bologna. Such extension will be implemented on the Marconi A2 partition, equipped with Intel Knights Landing (KNL) processors. A number of technical challenges were faced and solved in order to successfully run on low RAM nodes, as well as to overcome the closed environment (network, access, software distribution, … ) that HPC systems deploy with respect to standard GRID sites. We show preliminary results from a large scale integration effort, using resources secured via the successful PRACE grant N. 2018194658, for 30 million KNL core hours.
Computing for the DUNE Long-Baseline Neutrino Oscillation Experiment
Authors: Schellman Heidi 
Published: November 2020

This paper is based on a talk given at Computing in High Energy Physics in Adelaide, South Australia, Australia in November 2019. It is partially intended to explain the context of DUNE Computing for computing specialists.
The Deep Underground Neutrino Experiment (DUNE) collaboration consists of over 180 institutions from 33 countries. The experiment is in preparation now, with commissioning of the first 10kT fiducial volume Liquid Argon TPC expected over the period 2025-2028 and a long data taking run with 4 modules expected from 2029 and beyond.
An active prototyping program is already in place with a short test-beam run with a 700T, 15,360 channel prototype of single-phase readout at the Neutrino Platform at CERN in late 2018 and tests of a similar sized dual-phase detector scheduled for mid-2019. The 2018 test-beam run was a valuable live test of our computing model. The detector produced raw data at rates of up to 2GB/s. These data were stored at full rate on tape at CERN and Fermilab and replicated at sites in the UK and Czech Republic. In total 1.2 PB of raw data from beam and cosmic triggers were produced and reconstructed during the six week testbeam run.
Baseline predictions for the full DUNE detector data, starting in the late 2020’s are 30-60 PB of raw data per year. In contrast to traditional HEP computational problems, DUNE’s Liquid Argon TPC data consist of simple but very large (many GB) 2D data objects which share many characteristics with astrophysical images. This presents opportunities to use advances in machine learning and pattern recognition as a frontier user of High Performance Computing facilities capable of massively parallel processing.
Explorative Untersuchungen zum Stoffwechsel bei Tumorpatienten: Substratbilanzen nicht befallener Organe
Authors: Holm Eggert , Blum Andreas , Konrad Mark-Holger , Heumann Barbara , Stasiunaitis Vytautas , Jentschura Dirk 
Published: November 2020

ZusammenfassungMaligne Tumoren können in tumorfreien Organen metabolische Veränderungen induzieren. Um solche Veränderungen zu kennzeichnen, wurden bei Tumorpatienten die periphere und splanchnische Nettoaufnahme bzw. Nettoabgabe energieliefernder Substrate und der Aminosäuren untersucht. Die Austauschraten von Substraten sind deren arteriovenöse Konzentrationsdifferenzen, multipliziert mit der Durchblutungsgröße.An der Studie nahmen 14 Patienten mit operablen gastrointestinalen Karzinomen und 16 metabolisch gesunde Kontrollpersonen teil. In die rechte Lebervene wurde ein Katheter geschoben; die splanchnische Durchblutung wurde mithilfe von Indozyaningrün gemessen. Ein zweiter Katheter wurde in einer Femoralvene platziert; die Beindurchblutung wurde durch Venenverschlussplethysmografie bestimmt.Die peripheren Gewebe der Tumorpatienten nahmen weniger Glukose auf und setzten weniger Glutamin frei als die der Kontrollen. Die übrigen femoralen und alle splanchnischen Substratbilanzen lagen in den Referenzbereichen.Die Befunde zeigen, dass bei Tumorpatienten Störungen des peripheren Glukose- und Glutaminstoffwechsels schon in einem frühen Krankheitsstadium eintreten. In diesem Stadium ist die hepatische Glukoneogenese noch nicht gesteigert.
Update: Immunsuppression bei Organtransplantationen
Authors: Kniepeiss Daniela , Rosenkranz Alexander R. , Fickert Peter , Schemmer Peter 
Published: November 2020

ZusammenfassungDie Immunsuppression ist eine wesentliche Grundvoraussetzung für eine erfolgreiche Transplantation. Zur Reduktion der teils beträchtlichen Nebenwirkungen werden Kombinationstherapien mit unterschiedlichen Wirkstoffen durchgeführt. Dieser Beitrag soll einen aktuellen Überblick zur Immunsuppression nach Leber- und Nierentransplantation geben.
Endosonografisch gestützteTherapie der Cholangiolithiasis bei chirurgisch veränderter Anatomie – eine monozentrische Fallstudie
Authors: Fueldner Frank , Meyer Frank , Will Uwe 
Published: November 2020

ZusammenfassungZiel Untersuchung von Machbarkeit und Outcome EUS-gestützter Steinextraktionstechniken über einen transhepatischen Zugang bei Patienten mit postoperativ modifizierter Anatomie.Material/Methoden Alle konsekutiven Patienten (Pat.) mit Cholangiolithiasis und operativ veränderter Anatomie nach ggf. frustranem ERC-Versuch wurden in diese monozentrische Fallstudie eingeschlossen und bzgl. des technischen/klinischen Erfolgs charakterisiert.Ergebnisse Von 2004 bis 03/2020 wurden bei 449 Pat. EUS-gestützte Gallenwegdrainagen durchgeführt (n = 37 Pat. mit Cholangiolithiasis). Bei 8 der 37 Pat. erfolgte die Steinextraktion in EUS-ERCP-Rendezvoustechnik (kein Bestandteil der Studie, da keine operativ veränderte Anatomie vorlag). Bei 13 der verbleibenden 29 Pat. (45 %) wurden im Vorfeld frustrane Versuche der ballonenteroskopischen ERCP bei fehlender Erreichbarkeit der Papilla Vateri bzw. der biliodigestiven Anastomose unternommen. Der EUS-gestützte Zugang zu den Gallenwegen gelang bei allen 29 Pat. Die Steinextraktion erfolgte bei 26 Pat. (90 %) in antegrader Push-Technik nach vorheriger Ballondilatation der Papilla Vateri beziehungsweise der biliodigestiven Anastomose. Bei 11 Pat. (42 %) erfolgte nachfolgend zur Schienung der Papilla Vateri/biliodigestiven Anastomose die Einlage einer Doppelpigtailprothese („Ringdrainage“), die in der Regel nach 3 Monaten nach vorheriger sonografischer und laborchemischer Kontrolle mittels Gastroskopie wieder entfernt wurde. Bei 2 Pat. (7 %) erfolgte die Steinextraktion retrograd über den transhepatischen Zugang, bei 1 Pat. (3 %) wurde die Steinextraktion kombiniert in antegrader und retrograder Technik vorgenommen. Bei 2 Pat. (7 %) kam eine Cholangioskopie mit elektrohydraulischer Lithotripsie zum Einsatz.Die technische und klinische Erfolgsrate der Steinextraktion lag bei 100 % (29 von 29 Pat.). Re-Interventionen erfolgten bei 6 Pat. (21 %), Komplikationen traten bei 6 Pat. (21 %) auf.Schlussfolgerung Die EUS-gestützte Steinextraktion in antegrader oder retrograder Technik bei Patienten mit operativ veränderter Anatomie ist eine sichere, wenn auch technisch anspruchsvolle Methode der interventionellen Endoskopie/EUS. Sie hat eine hohe technische und klinische Erfolgsrate und eine niedrige Komplikationsrate. Sie hat das Potenzial, die zeitaufwendige ERCP mit Ballon-Enteroskopen und v. a. auch die PTCD und somit sekundäre und tertiäre Therapiealternativen zu ersetzen.
Immunotherapy in Pancreatic Cancer
Authors: El-Rayes Bassel F. , Akce Mehmet 
Published: November 2020

AbstractPancreatic cancer has a dismal prognosis and is projected to be the second most common cause of cancer-related mortality by 2030. Although modest improvement in survival with current conventional cytotoxic chemotherapy-based regimens, 5-year overall survival is still 9%. Despite becoming standard of care in several malignancies, single agent or dual check point inhibitor therapy is not effective in pancreatic cancer except in subgroup of patients with high microsatellite instability or high tumor mutational burden. Profoundly immunosuppressive tumor microenvironment of pancreatic cancer is a major barrier for success of immunotherapy. Rigorous research efforts are underway to explore immune-based combination therapy with chemotherapy, radiation therapy, stroma-modifying agents, vaccines, and targeted therapies. This article aims to provide a review of the ongoing research in pancreatic cancer immunotherapy.
Sex and gender considerations in health research: a trainee and allied research personnel perspective
Authors: Kalenga C. Z. , Parsons Leigh J. , Griffith J. , Wolf D. C. , Dumanski S. M. , Desjarlais A. , Petermann L. , Ahmed S. B. 
Published: November 2020

AbstractThe first step in precision health is the incorporation of sex and gender-based considerations and increasingly, a number of national organizations have instituted policies to support and encourage this practice. However, perspectives of trainees and allied research personnel on incorporation of sex and gender into research is lacking. We assessed trainee (undergraduate and graduate students, post-doctoral fellows, clinical trainees) and allied research personnel (study nurses, laboratory managers) perspectives on the barriers to incorporating sex and gender into their own university-based health research and recommendations to improve the process. Two separate focus groups were completed, and a qualitative analysis was employed to derive themes within perceived barriers and solutions. Participants described three overarching themes consistent with barriers including, lack of knowledge and skill, lack of applicability and feasibility, and lack of funding agency and institutional culture. Participants recommended: (1) increasing awareness and skill of incorporation of sex and gender considerations into health research; (2) implementing practical education curricula to facilitate understanding; and (3) fostering greater transparency and accountability by funding organizations and journal editors. Sex and gender considerations in research contribute to precision health, drive innovation and foster breakthroughs in science and medicine.
Supplementary comparison EURAMET.L-S25 (#1354). Comparison of pocket type laser distance measuring instruments
Authors: Prieto Emilio , Pérez Ma Mar , Ruíz Juan A , Matus Michael , Kotte Gerard 
Published: November 2020

Supplementary comparison of distance measurements using pocket-type laser instruments (EDMs), following the previous comparison EURAMET.L-S20.
Originally proposed by CEM (ES) as billateral comparison with BEV (AT), after the open call made at the 2014 EURAMET TC-L meeting, VSL (NL) joined the comparison too.
Registered as Supplementary Comparison EURAMET.L-S25 with CEM acting as Coordinator and Pilot laboratory.
Transfer devices were two Leica DISTO EDMs, being the measurands the distances from the rear part of the EDMs to a target plate situated at 0.3 m and every 5 m until covering a range of 50 m.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the EURAMET and CCL WG-MRA, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Pancakes as opposed to Swiss cheese
Authors: Nájera S , Sussman R A 
Published: November 2020

Abstract
We examine a novel class of toy models of cosmological inhomogeneities by smoothly matching along a suitable hypersurface an arbitrary number of sections of ‘quasi flat’ inhomogeneous and anisotropic Szekeres-II models to sections of any spatially flat cosmology that can be described by the Robertson–Waker metric (including de Sitter, anti de Sitter and Minkowski spacetimes). The resulting ‘pancake’ models are quasi-flat analogues to the well known spherical ‘Swiss-cheese’ models found in the literature. Since Szekeres-II models can be, in general, compatible with a wide range of sources (dissipative fluids, mixtures of non-comoving fluids, mixtures of fluids with scalar or magnetic fields or gravitational waves), the pancake configurations we present allow for a description of a wide collection of localized sources embedded in a Robertson–Waker geometry. We provide various simple examples of arbitrary numbers of Szekeres-II regions (whose sources are comoving dust and energy flux interpreted as a field of peculiar velocities) matched with Einstein de Sitter, ΛCDM and de Sitter backgrounds. We also prove that the Szekeres-II regions can be rigorously regarded as ‘exact’ covariant perturbations on a background defined by the matching discussed above. We believe that these models can be useful to test ideas on averaging and backreaction and on the effect of inhomogeneities on cosmic evolution and observations.