bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salt tectonics in the Eastern Mediterranean Sea: Where a giant delta meets a salt giant
Authors: Zucker Elchanan , Gvirtzman Zohar , Steinberg Josh , Enzel Yehouda 
Published: November 2019

AbstractThe circum-Nile deformation belt (CNDB) demonstrates the interaction between a giant delta and a giant salt body. The semi-radial shape of the CNDB is commonly interpreted as the product of salt squeezing out from under the Nile Delta. We demonstrate, however, that this is not the dominant process, because the delta and its deep-sea fan do not reach the deep-basin salt. The distal part of the deep-sea fan overlies the edge of the salt giant, but squeezing this edge (&lt;150 m thickness) should have had only little effect on the regional salt tectonics. Only on the easternmost side of the deep-sea fan, toward the Levant Basin, does the squeeze-out model work. Here, the delta front reaches the thick salt layer and differential loading promotes basinward salt flow, even upslope. On the western side of the delta, downslope gliding of the sediment-salt sequence toward the Herodotus Basin is driven by the elevation gradient toward the deepest part of the basin. Our analysis shows that salt squeezing by differential loading was previously overestimated in the Eastern Mediterranean and raises the need to carefully map the boundary of salt basins prior to any interpretation. This conclusion is especially relevant in young basins where deltas and shelves have not propagated far enough into the basin.
Controls on the structural and stratigraphic evolution of the megaflap-bearing Sinbad Valley salt wall, NE Paradox Basin, SW Colorado
Authors: Thompson Jobe Jessica Ann , Giles Katherine A. , Hearon Thomas E. , Rowan Mark G. , Trudgill Bruce , Gannaway Dalton C. Evelyn , Jobe Zane R. 
Published: November 2019

Abstract
The interplay between sedimentation and salt rise around a diapir results in distinct geometries that can be used to determine the structural and stratigraphic history within a basin. Using new geologic mapping, measured stratigraphic sections, and subsurface interpretations of seismic and well logs, we describe circum-diapir stratal geometries and deformation at the Sinbad Valley salt wall in the proximal, northeastern Paradox Basin, southwest Colorado (USA). We interpret these geometries in the context of newly recognized halokinetic features and salt-associated deformation (megaflaps, counterregional faults, intrasalt inclusions), present a revised stratigraphic and salt tectonic history of Sinbad Valley diapir, and compare these proximal features to those at the distal Gypsum Valley diapir and infer local versus regional controls on their formation. The deposition of conglomerates within the Paradox Formation, now preserved as intrasalt inclusions in the center of Sinbad Valley, record early elevation of the Uncompahgre Uplift. Subsequent differential sedimentary loading resulted in initiation of passive diapirism during the late Pennsylvanian through the latest Triassic/Early Jurassic, facilitated by movement on a NE-dipping, listric, counterregional fault that extends for &gt;22 km southeast of the diapir. Exposures of a steeply dipping stratal panel of late Pennsylvanian-aged Honaker Trail Formation along the southwestern flank of Sinbad Valley are interpreted as a megaflap, a preserved remnant of the diapir roof that was folded into a vertical position by drape-folding during passive salt rise. Significant lateral changes in the surface geometry and depositional facies of the megaflap define four structural domains that may result from a combination of radial faulting and varying degrees of folding via limb rotation or limb rotation with minor hinge migration. Using key differences between Sinbad Valley and Gypsum Valley salt walls in regard to the megaflap facies, timing of megaflap formation, and the presence of a Paradox Formation conglomeratic intrasalt inclusion, we conclude that salt wall position (i.e., proximal versus distal) within a basin influences the characteristics of some of these features, whereas the timing of other features (e.g., megaflap formation) appears to be similar throughout the basin suggesting a more regional control.
Structure and metamorphism of a subducted seamount (Zagros suture, Southern Iran)
Authors: Bonnet G. , Agard P. , Angiboust S. , Monié P. , Fournier M. , Caron B. , Omrani J. 
Published: November 2019

Abstract
Millions of seamounts on modern and past seafloor end up being subducted, and only small pieces are recovered in suture zones. How they are metamorphosed and deformed is, however, critical to understand how seamount subduction can impact subduction zone geometry, fluid circulation or seismogenic conditions, and more generally to trace physical conditions along the subduction boundary. Since geophysical studies mostly reach the shallowest subducted seamounts and miss internal structures due to low resolution, there is a high need for fossil seamount exposures. We herein report on a fully exposed, 3D example of seamount that we discovered in the Siah Kuh massif, Southern Iran. Through a series of sections across the whole massif and the combination of magmatic-metamorphic-sedimentary petrological data, we document several distinct stages associated with seamount build-up on the seafloor and with subduction. In particular, we constrain different stages of metamorphism and associated mineralogy, with precise conditions for subduction-related metamorphism around 250 °C and 0.7 GPa, in the middle of the seismogenic zone. Extensive examination of the seismogenic potential of the Siah Kuh seamount reveals that it was not a large earthquake asperity (despite the report of a rare example of cm-scale, high-pressure pseudotachylyte in this study), and that it possibly behaved as a barrier to earthquake propagation. Finally, we discuss the nature of high-pressure fluid circulation preserved in this seamount.
Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres
Authors: Kaura Amit , Panoulas Vasileios , Glampson Benjamin , Davies Jim , Mulla Abdulrahim , Woods Kerrie , Omigie Joe , Shah Anoop D , Channon Keith M , Weber Jonathan N , Thursz Mark R , Elliott Paul , Hemingway Harry , Williams Bryan , Asselbergs Folkert W , O’Sullivan Michael , Kharbanda Rajesh , Lord Graham M , Melikian Narbeh , Patel Riyaz S , Perera Divaka , Shah Ajay M , Francis Darrel P , Mayet Jamil 
Published: November 2019

Abstract

Objective
To determine the relation between age and troponin level and its prognostic implication.

Design
Retrospective cohort study.

Setting
Five cardiovascular centres in the UK National Institute for Health Research Health Informatics Collaborative (UK-NIHR HIC).

Participants
257 948 consecutive patients undergoing troponin testing for any clinical reason between 2010 and 2017.

Main outcome measure
All cause mortality.

Results
257 948 patients had troponin measured during the study period. Analyses on troponin were performed using the peak troponin level, which was the highest troponin level measured during the patient’s hospital stay. Troponin levels were standardised as a multiple of each laboratory’s 99th centile of the upper limit of normal (ULN). During a median follow-up of 1198 days (interquartile range 514-1866 days), 55 850 (21.7%) deaths occurred. A positive troponin result (that is, higher than the upper limit of normal) signified a 3.2 higher mortality hazard (95% confidence interval 3.1 to 3.2) over three years. Mortality varied noticeably with age, with a hazard ratio of 10.6 (8.5 to 13.3) in 18-29 year olds and 1.5 (1.4 to 1.6) in those older than 90. A positive troponin result was associated with an approximately 15 percentage points higher absolute three year mortality across all age groups. The excess mortality with a positive troponin result was heavily concentrated in the first few weeks. Results were analysed using multivariable adjusted restricted cubic spline Cox regression. A direct relation was seen between troponin level and mortality in patients without acute coronary syndrome (ACS, n=120 049), whereas an inverted U shaped relation was found in patients with ACS (n=14 468), with a paradoxical decline in mortality at peak troponin levels >70×ULN. In the group with ACS, the inverted U shaped relation persisted after multivariable adjustment in those who were managed invasively; however, a direct positive relation was found between troponin level and mortality in patients managed non-invasively.

Conclusions
A positive troponin result was associated with a clinically important increased mortality, regardless of age, even if the level was only slightly above normal. The excess mortality with a raised troponin was heavily concentrated in the first few weeks.

Study registration

ClinicalTrials.gov
NCT03507309
.
Arts for ageing well: a propensity score matching analysis of the effects of arts engagements on holistic well-being among older Asian adults above 50 years of age
Authors: Ho Andy Hau Yan , Ma Stephanie Hilary Xinyi , Ho Moon-Ho Ringo , Pang Joyce Shu Min , Ortega Emily , Bajpai Ram 
Published: November 2019

ObjectiveTo assess the frequency and intensity of arts engagement inclusive of active and passive engagements in arts, culture and heritage activities among Singaporean adults aged 50 and above, and examine the relationships between participatory art and holistic well-being.DesignCross-sectional stratified household survey.SettingAll residential areas across Singapore’s Central, East, North, North-East and West Regions.Participants1067 community-dwelling, Singaporean older adults between the ages of 50 and 95 years were recruited.Primary and secondary outcome measuresRespondents completed a self-reported questionnaire, consisting of standardised ad hoc items assessing the frequencies and durations of active and passive participatory arts engagement, as well as validated psychometric assessments on psychosociospiritual health including the primary outcome measure on quality of life, and the secondary outcome measures on physical, psychological, emotional, spiritual, and social well-being. sociodemographic information, as well as frequency and intensity of physical activity were also collected.ResultsPassive engagement (60%) and active engagement (17%) in the arts were associated with better holistic wellness and social support. Specifically, findings from the propensity score matching and independent t-test analyses revealed that adults aged 50 and above who passively engaged in arts and culture-related events experienced higher quality of life (t(728)=3.35, p=0.0008,d=0.25), perceived health (t(728)=2.21, p=0.0277,d=0.16) and sense of belonging (t(728)=2.17, p=0.03,d=0.16), as compared with those who did not. Moreover, those who actively engaged in participatory arts experienced greater quality of life (t(442)=3.68, p=0.0003,d=0.36), self-rated health (t(442)=2.59, p=0.0099,d=0.25), spiritual well-being (t(442)=3.75, p=0.0002,d=0.37), meaning in life (t(442)=5.03, p<0.0001,d=0.50) and sense of peace (t(442)=3.72, p=0.0002,d=0.36), as compared with those who did not actively engaged in the arts.ConclusionThis study provided robust evidence to support a significant causal relationship between arts engagements and holistic well-being. Recommendations for art-based public health and elderly care research, practice and policy are discussed.
Effects of physical activity interventions on the body mass index of children and adolescents in Latin America: a protocol for a systematic review and meta-analysis
Authors: Godoy-Cumillaf Andrés , Diaz Armando , Álvarez-Bueno Celia , Martinez-Vizcaino Vicente , Cavero-Redondo Iván 
Published: November 2019

IntroductionIn Latin America, the number of children and adolescents who are overweight or obese has significantly increased in recent decades, and this situation has become a major public health concern. To address this problem, several intervention programmes, based on factors such as physical activity and nutrition, have been implemented, and body mass index (BMI) has been widely used as a means of measuring the impact of such interventions. Although some Latin America-based systematic reviews have been performed, there have been no previous meta-analyses of findings regarding the effect of physical activity interventions on BMI. Thus, the objective of the systematic review and meta-analysis will be to provide an up-to-date synthesis of the effects of physical activity interventions on BMI of Latin American children and adolescents aged 4–18 years.Methods and analysisThis systematic review and meta-analysis protocol is based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. The literature search will involve MEDLINE, EMBASE, Cochrane Library, Web of Science and Scielo for articles published up to July 2019. This search will include randomised controlled trials (RCTs), non-randomised experimental studies and single-arm pre–post studies. Further, the Cochrane Collaboration’s tool for RCT studies and the Quality Assessment Tool for Quantitative Studies for non-randomised experimental and single-arm pre–post studies will be used to assess the risk of bias among the studies included in the systematic review. For the meta-analysis, the statistical program STATA V.14 will be used, and standardised mean differences are calculated as the primary outcomes. Subgroup analyses will then be performed based on the characteristics of the interventions and populations included in the studies examined.Ethics and disseminationThis systematic review protocol is designed to provide updated evidence regarding the effects of physical activity interventions on the Latin American population; such evidence may be useful for institutions responsible for the development of public health policies and for those tasked with implementing such interventions among children and adolescents in Latin America. The results should be disseminated through publication in a peer-reviewed journal. Since the data used in systematic reviews of this type will be extracted exclusively from published studies, approval from an ethics committee will not be required.PROSPERO registration numberCRD42019077702.
The Incentives to Quit tobacco in Pregnancy (IQuiP) protocol: piloting a financial incentive-based smoking treatment for women attending substance use in pregnancy antenatal services
Authors: Jackson Melissa A , Brown Amanda L , Baker Amanda L , Gould Gillian S , Dunlop Adrian J 
Published: November 2019

IntroductionWhile tobacco smoking prevalence is falling in many western societies, it remains elevated among high-priority cohorts. Rates up to 95% have been reported in women whose pregnancy is complicated by other substance use. In this group, the potential for poor pregnancy outcomes and adverse physical and neurobiological fetal development are elevated by tobacco smoking. Unfortunately, few targeted and effective tobacco dependence treatments exist to assist cessation in this population. The study will trial an evidence-based, multicomponent tobacco smoking treatment tailored to pregnant women who use other substances. The intervention comprises financial incentives for biochemically verified abstinence, psychotherapy delivered by drug and alcohol counsellors, and nicotine replacement therapy. It will be piloted at three government-based, primary healthcare facilities in New South Wales (NSW) and Victoria, Australia. The study will assess the feasibility and acceptability of the treatment when integrated into routine antenatal care offered by substance use in pregnancy antenatal services.Methods and analysisThe study will use a single-arm design with pre–post comparisons. One hundred clients will be recruited from antenatal clinics with a substance use in pregnancy service. Women must be <33 weeks’ gestation, ≥16 years old and a current tobacco smoker. The primary outcomes are feasibility, assessed by recruitment and retention and the acceptability of addressing smoking among this population. Secondary outcomes include changes in smoking behaviours, the comparison of adverse maternal outcomes and neonatal characteristics to those of a historical control group, and a cost-consequence analysis of the intervention implementation.Ethics and disseminationProtocol approval was granted by Hunter New England Human Research Ethics Committee (Reference 17/04/12/4.05), with additional ethical approval sought from the Aboriginal Health and Medical Research Council of NSW (Reference 1249/17). Findings will be disseminated via academic conferences, peer-reviewed publications and social media.Trial registration numberAustralia New Zealand Clinical Trial Registry (Ref: ACTRN12618000576224).
Transcultural mediation programme in a paediatric hospital in France: qualitative and quantitative study of participants’ experience and impact on hospital costs
Authors: Lachal Jonathan , Escaich Mélanie , Bouznah Serge , Rousselle Clémence , De Lonlay Pascale , Canoui Pierre , Moro Marie-Rose , Durand-Zaleski Isabelle 
Published: November 2019

ObjectiveIn France, immigrants with chronic diseases encounter numerous difficulties in gaining access to care and then in its initiation and organisation, difficulties only partly explained by socioeconomic factors. Atranscultural mediationconsultation programme has been set up in Necker Hospital in Paris to help families and professionals deal with these situations. The objective of this study was to assess the economic impact and the experience of this consultation.DesignQualitative and quantitative descriptive study.SettingThis study of inpatients treated at Necker Hospital included those whose families participated in transcultural mediation in 2014 through 2016.ParticipantsThe first portion of the study applied quantitative methods and compared hospital costs before and after the mediation from the patients' records and accounting data for 15 cases. The qualitative portion analysed 15 semistructured interviews of physicians and families after the mediation, and a focus group of three psychologists.ResultsThe results show a systematic reduction in costs after mediation, associated with fewer emergency hospitalisations and the shift of care toward less specialised facilities, calmer relationships between families and professionals, improved mutual understanding and increased confidence by the professionals in the families' ability to manage the treatment.ConclusionTranscultural mediation can benefit both patients and the healthcare system and may be useful for other hospitals that care for socially and culturally diverse patients.
Benefits of not smoking during pregnancy for Australian Aboriginal and Torres Strait Islander women and their babies: a retrospective cohort study using linked data
Authors: McInerney Carol , Ibiebele Ibinabo , Ford Jane B , Randall Deborah , Morris Jonathan M , Meharg David , Mitchell Jo , Milat Andrew , Torvaldsen Siranda 
Published: November 2019

ObjectivesTo provide evidence for targeted smoking cessation policy, the aim of this study was to compare pregnancy outcomes of Aboriginal mothers who reported not smoking during pregnancy with Aboriginal mothers who reported smoking during pregnancy.DesignPopulation based retrospective cohort study using linked data.SettingNew South Wales, the most populous Australian state.Population18 154 singleton babies born to 13 477 Aboriginal mothers between 2010 and 2014 were identified from routinely collected New South Wales datasets. Aboriginality was determined from birth records and from four linked datasets through an Enhanced Reporting of Aboriginality algorithm.ExposureNot smoking at any time during pregnancy.Main outcome measuresUnadjusted and adjusted relative risks (aRR) and 95% CIs from modified Poisson regression were used to examine associations between not smoking during pregnancy and maternal and perinatal outcomes including severe morbidity, inter-hospital transfer, perinatal death, preterm birth and small-for-gestational age. Population attributable fractions (PAFs) were calculated using adjusted relative risks.ResultsCompared with babies born to mothers who smoked during pregnancy, babies born to non-smoking mothers had a lower risk of all adverse perinatal outcomes including perinatal death (aRR=0.58, 95% CI 0.44 to 0.76), preterm birth (aRR=0.58, 95% CI 0.53 to 0.64) and small-for-gestational age (aRR=0.35, 95% CI 0.32 to 0.39). PAFs (%) were 27% for perinatal death, 26% for preterm birth and 48% for small-for-gestational-age. Compared with women who smoked during pregnancy (n=8919), those who did not smoke (n=9235) had a lower risk of being transferred to another hospital (aRR=0.76, 95% CI 0.66 to 0.89).ConclusionsBabies born to women who did not smoke during pregnancy had a lower risk of adverse perinatal outcomes. Rates of adverse outcomes among Aboriginal non-smokers were similar to those among the general population. These results quantify the proportion of adverse perinatal outcomes due to smoking and highlight why effective smoking cessation programme are urgently required for this population.
Renin–angiotensin system blocker use and the risk of acute kidney injury after colorectal cancer surgery: a population-based cohort study
Authors: Slagelse Charlotte , Gammelager H , Iversen Lene Hjerrild , Liu Kathleen D , Sørensen Henrik T Toft , Christiansen Christian F 
Published: November 2019

ObjectivesIt is unknown whether preoperative use of ACE inhibitors (ACE-I) or angiotensin receptor blockers (ARBs) affects the risk of acute kidney injury (AKI) after colorectal cancer (CRC) surgery. We assessed the impact of preoperative ACE-I/ARB use on risk of AKI after CRC surgery.DesignObservational cohort study. Patients were divided into three exposure groups—current, former and non-users—through reimbursed prescriptions within 365 days before the surgery. AKI within 7 days after surgery was defined according to the current Kidney Disease Improving Global Outcome consensus criteria.SettingPopulation-based Danish medical databases.ParticipantsA total of 9932 patients undergoing incident CRC surgery during 2005–2014 in northern Denmark were included through the Danish Colorectal Cancer Group Database.Outcome measureWe computed cumulative incidence proportions (risk) of AKI with 95% CIs for current, former and non-users of ACE-I/ARB, including death as a competing risk. We compared current and former users with non-users by computing adjusted risk ratios (aRRs) using log-binomial regression adjusted for demographics, comorbidities and CRC-related characteristics. We stratified the analyses of ACE-I/ARB users to address any difference in impact within relevant subgroups.ResultsTwenty-one per cent were ACE-I/ARB current users, 6.4% former users and 72.3% non-users. The 7-day postoperative AKI risk for current, former and non-users was 26.4% (95% CI 24.6% to 28.3%), 25.2% (21.9% to 28.6%) and 17.8% (17.0% to 18.7%), respectively. The aRRs of AKI were 1.20 (1.09 to 1.32) and 1.16 (1.01 to 1.34) for current and former users, compared with non-users. The relative risk of AKI in current compared with non-users was consistent in all subgroups, except for higher aRR in patients with a history of hypertension.ConclusionsBeing a current or former user of ACE-I/ARBs is associated with an increased risk of postoperative AKI compared with non-users. Although it may not be a drug effect, users of ACE-I/ARBs should be considered a risk group for postoperative AKI.