bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss
Authors: Massopust Ryan T. , Lee Young il , Pritchard Anna L. , Nguyen Van-Khoa M. , McCreedy Dylan A. , Thompson Wesley J. 
Published: October 2020

AbstractThe muscular dystrophy X-linked mouse (mdx) is the most commonly used preclinical model for Duchenne muscular dystrophy. Although disease progression in the mouse does not perfectly model the human disease, it shares many pathological features. Early characterizations of the model reported severe pathology through early adulthood followed by disease stabilization. As a result, research in the mdx mouse has largely focused on early adulthood. The overarching goal of this study is to improve the understanding of the mdx mouse model by tracking pathological features of the disease throughout life. We performed a thorough characterization of myofiber pathology in mdx mice from 2 weeks to 2 years of age. We report that individual mdx muscle fibers undergo progressive hypertrophy that continues through the lifespan. Despite massive hypertrophy on the myofiber level, we report no hypertrophy on the muscle level. These seemingly contradictory findings are explained by previously underappreciated myofiber loss in mdx mice. We conclude that due to myofiber loss, in combination with the progressive nature of other pathological features, aged mdx muscle tissue provides reliable benchmarks for disease progression that may be valuable in testing the efficacy of therapeutics for Duchenne muscular dystrophy.
Using whole-exome sequencing and protein interaction networks to prioritize candidate genes for germline cutaneous melanoma susceptibility
Authors: Yepes Sally , Tucker Margaret A. , Koka Hela , Xiao Yanzi , Jones Kristine , Vogt Aurelie , Burdette Laurie , Luo Wen , Zhu Bin , Hutchinson Amy , Yeager Meredith , Hicks Belynda , Freedman Neal D. , Chanock Stephen J. , Goldstein Alisa M. , Yang Xiaohong R. 
Published: October 2020

AbstractAlthough next-generation sequencing has demonstrated great potential for novel gene discovery, confirming disease-causing genes after initial discovery remains challenging. Here, we applied a network analysis approach to prioritize candidate genes identified from whole-exome sequencing analysis of 98 cutaneous melanoma patients from 27 families. Using a network propagation method, we ranked candidate genes by their similarity to known disease genes in protein–protein interaction networks and identified gene clusters with functional connectivity. Using this approach, we identified several new candidate susceptibility genes that warrant future investigations such as NGLY1, IL1RN, FABP2, PRKDC, and PROSER2. The propagated network analysis also allowed us to link families that did not have common underlying genes but that carried variants in genes that interact on protein–protein interaction networks. In conclusion, our study provided an analysis perspective for gene prioritization in the context of genetic heterogeneity across families and prioritized top potential candidate susceptibility genes in our dataset.
Dynamics of soil ingestion by growing bulls during grazing on a high sward height in the French West Indies
Authors: Collas Claire , Mahieu Maurice , Badot Pierre-Marie , Crini Nadia , Rychen Guido , Feidt Cyril , Jurjanz Stefan 
Published: October 2020

AbstractFree-range livestock are exposed to environmental contaminants by ingesting contaminated matrices mainly soil. Several works evaluated precisely the soil ingestion and its variation factors in ruminants. Contrary to temperate grazing systems, tropical ones were poorly documented whereas weather or traditional grazing practices may change models established in temperate systems. The study was performed in the French West Indies, which are concerned by a widespread environmental chlordecone contamination. The work evaluated daily soil and grass ingestions by tethered growing bulls grazing on a very high sward close to 50 cm for 11 days without being moved. This grazing management is representative to local practices by small farmers or not professional holders and allows completing the results previously obtained. Daily soil ingestion did not significantly increase across time and was on average 26.9 g dry matter/100 kg body weight (i.e. 1.4% of the total mass ingested). Marked individual variations indicated that exposure risk assessments would require experimental designs based on a sufficient number of individuals. This study was also the first to investigate the changes in sward soiling with respect to the distance from the stake and reported lower soil loading on grass in the peripheral than central and intermediate areas.
The topology of higher-order complexes associated with brain hubs in human connectomes
Authors: Andjelković Miroslav , Tadić Bosiljka , Melnik Roderick 
Published: October 2020

AbstractHigher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified core networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes.
Making EuO multiferroic by epitaxial strain engineering
Authors: Goian Veronica , Held Rainer , Bousquet Eric , Yuan Yakun , Melville Alexander , Zhou Hua , Gopalan Venkatraman , Ghosez Phillipe , Spaldin Nicola A. , Schlom Darrell G. , Kamba Stanislav 
Published: October 2020

AbstractMultiferroics are materials exhibiting the coexistence of ferroelectricity and ideally ferromagnetism. Unfortunately, most known magnetoelectric multiferroics combine ferroelectricity with antiferromagnetism or with weak ferromagnetism. Here, following previous theoretical predictions, we provide clear experimental indications that ferroelectricity can be induced by epitaxial tensile strain in the ferromagnetic simple binary oxide EuO. We investigate the ferroelectric phase transition using infrared reflectance spectroscopy, finding that the frequency of the soft optical phonon reduces with increasing tensile strain and decreasing temperature. We observe such a soft mode anomaly at 100 K in (EuO)2/(BaO)2 superlattices grown epitaxially on (LaAlO3)0.29-(SrAl1/2Ta1/2O3)0.71 substrates, which is a typical signature for a displacive ferroelectric phase transition. The EuO in this superlattice is nominally subjected to 6.4% biaxial tensile strain, i.e., 50% more than believed needed from previously published calculations. We interpret our results with new first-principles density functional calculations using a hybrid functional, which provides a better quantitative agreement with experiment than the previously used local-density approximation and generalized gradient approximation functionals.
Synthesis and characterization of the mixed-ligand coordination polymer Cu3Cl(N4C-NO2)2
Authors: Westwater Bradley , Lloyd Hayleigh J. , Vitorica-Yrezabal Inigo J. , Fong Angela , McMaster Patrick , Sloan Martin , Coaker Brian M. , Pulham Colin R. , Portius Peter 
Published: October 2020

An unexpected novel energetic material was found in seed crystal-controlled CuCl2 – Na(N4C-NO2) – sodium ascorbate reduction reactions.
Cardiovascular toxicity of PI3Kα inhibitors
Authors: Sadasivan Chandu , Zhabyeyev Pavel , Labib Dina , White James A. , Paterson D. Ian , Oudit Gavin Y. 
Published: October 2020

AbstractThe phosphoinositide 3-kinases (PI3Ks) are a family of intracellular lipid kinases that phosphorylate the 3′-hydroxyl group of inositol membrane lipids, resulting in the production of phosphatidylinositol 3,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. This results in downstream effects, including cell growth, proliferation, and migration. The heart expresses three PI3K class I enzyme isoforms (α, β, and γ), and these enzymes play a role in cardiac cellular survival, myocardial hypertrophy, myocardial contractility, excitation, and mechanotransduction. The PI3K pathway is associated with various disease processes but is particularly important to human cancers since many gain-of-function mutations in this pathway occur in various cancers. Despite the development, testing, and regulatory approval of PI3K inhibitors in recent years, there are still significant challenges when creating and utilizing these drugs, including concerns of adverse effects on the heart. There is a growing body of evidence from preclinical studies revealing that PI3Ks play a crucial cardioprotective role, and thus inhibition of this pathway could lead to cardiac dysfunction, electrical remodeling, vascular damage, and ultimately, cardiovascular disease. This review will focus on PI3Kα, including the mechanisms underlying the adverse cardiovascular effects resulting from PI3Kα inhibition and the potential clinical implications of treating patients with these drugs, such as increased arrhythmia burden, biventricular cardiac dysfunction, and impaired recovery from cardiotoxicity. Recommendations for future directions for preclinical and clinical work are made, highlighting the possible role of PI3Kα inhibition in the progression of cancer-related cachexia and female sex and pre-existing comorbidities as independent risk factors for cardiac abnormalities after cancer treatment.
Erweiterte Reanimationsmaßnahmen: die extrakorporale kardiopulmonale Reanimation
Authors: Ohlemacher Florian , Lichy Gregor 
Published: October 2020

ZusammenfassungEine extrakorporale kardiopulmonale Reanimation (eCPR) gilt als Therapieoption bei therapierefraktärem Herz-Kreislauf-Versagen. Sie kann die Überlebensrate mit günstigem neurologischem Ergebnis bei hochselektierten Patienten deutlich verbessern. Dieser Beitrag schildert das Verfahren, die Kriterien bei der Entscheidung zur eCPR sowie die Vor- und Nachteile der beiden Optionen – In-Hospital- und Out-of-Hospital-Variante – der eCPR.
Overlapping subjunctive forms in Gallo- and Ibero-Romance verb paradigms
Authors: Esher Louise 
Published: October 2020

Abstract
In several varieties of Catalan, Valencian and Occitan, inflectional exponents originating in the imperfect
subjunctive (reflex of Latin pluperfect subjunctive) are analogically extended into the first and second person plural present
subjunctive forms, resulting in syncretism between present and imperfect subjunctive forms for the relevant persons. The scope and
directionality of such extensions are remarkably consistent, and are indicative of a change driven by the structure of the
inflectional paradigm in the relevant varieties. A significant consequence of this development, which fits into a general Romance
tendency for analogical remodelling of first and second person plural forms, is alignment between previously overlapping
distributions of stem allomorphs and stress placement, and thus greater predictability of inflected forms.
Plasma augmented structural and electrical properties of half doped neodymium strontium manganites
Authors: Chettri Pronita , Sarma Arun , Okram G S , Rao Ashok , Deka Utpal 
Published: October 2020

Abstract
The reduction in resistivity and modification of the thermoelectric power of perovskite oxides is in continuous demand because of its large scale industrial applications. Currently, electron or ion beam irradiations are the most preferred methods employed to improve its properties. The quantum of improvement achieved with these methods is appreciable, however, it involves intriguing technicalities in the production of the beams. Plasma is a natural medium with the presence of both electrons and ions that can be easily produced using the glow discharge technique. In this work, the effect of oxygen plasma exposure on the structural properties, electrical resistivity, and thermopower of Nd0.5Sr0.5MnO3 manganites is investigated. Powdered Nd0.5Sr0.5MnO3 manganites samples are prepared using the solid-state reaction method. It is found that plasma exposure has changed the lattice parameters thereby varying the cell volume, which are not normally seen in the case of electron beam exposure. Further, the electrical resistivity is observed to decrease significantly after plasma exposure that changed the transport properties. It is also observed that plasma exposure decreases the absolute value of thermopower at low temperatures but increases it at high temperatures.
Bulk viscosity for interacting strange quark matter and r-mode instability windows for strange stars *
Authors: Xu Jian-Feng , Kang Dong-Biao , Peng Guang-Xiong , Xia Cheng-Jun 
Published: October 2020

Abstract
We investigate the bulk viscosity of strange quark matter in the framework of the equivparticle model, where analytical formulae are obtained for certain temperature ranges, which can be readily applied to those with various quark mass scalings. In the case of adopting a quark mass scaling with both linear confinement and perturbative interactions, the obtained bulk viscosity increases by

orders of magnitude compared with those in bag model scenarios. Such an enhancement is mainly due to the large quark equivalent masses adopted in the equivparticle model, which are essentially attributed to the strong interquark interactions and are related to the dynamical chiral symmetry breaking. Due to the high bulk viscosity, the predicted damping time of oscillations for a canonical 1.4

strange star is less than one millisecond, which is shorter than previous findings. Consequently, the obtained

-mode instability window for the canonical strange stars well accommodates the observational frequencies and temperatures for pulsars in low-mass X-ray binaries (LMXBs).
A Correlation-Driven Mapping For Deep Learning application in detecting artifacts within the EEG
Authors: Bahador Nooshin , Erikson Kristo , Laurila Jouko , Koskenkari Juha , Ala-Kokko Tero , Kortelainen Jukka 
Published: October 2020

Abstract

Objective. When developing approaches for automatic preprocessing of electroencephalogram (EEG) signals in non-isolated demanding environment such as intensive care unit (ICU) or even outdoor environment, one of the major concerns is varying nature of characteristics of different artifacts in time, frequency and spatial domains, which in turn causes a simple approach to be not enough for reliable artifact removal. Considering this, current study aims to use correlation-driven mapping to improve artifact detection performance. Approach. A framework is proposed here for mapping signals from multichannel space (regardless of the number of EEG channels) into two-dimensional RGB space, in which the correlation of all EEG channels is simultaneously taken into account, and a deep convolutional neural network (CNN) model can then learn specific patterns in generated 2D representation related to specific artifact. Main results. The method with a classification accuracy of 92.30% (AUC = 0.96) in a leave-three-subjects-out cross-validation procedure was evaluated using data including 2310 EEG sequences contaminated by artifacts and 2285 artifact-free EEG sequences collected with BrainStatus self-adhesive electrode and wireless amplifier from 15 intensive care patients. For further assessment, several scenarios were also tested including performance variation of proposed method under different segment lengths, different numbers of isoline and different numbers of channel. The results showed outperformance of CNN fed by correlation coefficients data over both spectrogram-based CNN and EEGNet on the same dataset. Significance. This study showed the feasibility of utilizing correlation image of EEG channels coupled with deep learning as a promising tool for dimensionality reduction, channels fusion and capturing various artifacts patterns in temporal-spatial domains. A simplified version of proposed approach was also shown to be feasible in real-time application with latency of 0.0181 s for making real-time decision.
Research on the Visual Interaction Design of Tourism Destination Brands Based on Regional Features
Authors: Zhang Yanhua , Wang Xiaoyan 
Published: October 2020

Abstract
In the process of rapid development of my country’s tourism industry, there are serious problems in the homogeneity of tourist destinations and tourism projects, which will affect the brand building effect of tourist destinations to a certain extent. Through the analysis of the design theory and design model of tourism destination image in the current development process of tourism industry, we can find that regional brand is the main core in the design process of tourism destination. Visual design plays an important role in shaping the brand image of tourist destinations. Therefore, we need to pay attention to the effective connection between the image design of regional tourism destinations, and explore the methods and approaches of image design for regional tourism destinations. Only in this way can the brand design level of the tourist destination be improved.
Application and Research of Computer VR Technology in Digital Media System Design
Authors: Yu Sihui , Chen Fuzhong , Guo Tianyi , Meng Hui , Chen Xiaoman , Li Zhengpeng 
Published: October 2020

Abstract
This paper first analyzes the definition of computer VR technology and the transmission of information data, and then expounds how to use VR technology to establish a complete digital media design system; Finally, deeply analyzes the application of VR technology in the design of digital media system, including the detailed discussion and planning of user interaction, information dissemination mode and information reception mode. According to the current situation of digital media development in China, the computer VR technology is introduced to improve the operation process of digital media, so that the digital media design system can be improved.
RETRACTED: Innovation and Practice of College English Teaching Model Based on Computer Network
Authors: Zhao Qian , Li Chunyan 
Published: October 2020

Abstract
This article analyzes the current status of the application of the college English teaching model, including students’ low interest in learning, strong unity of teaching model, and a large proportion of theoretical courses. The author combines the application characteristics and application value of the computer network, through studying how to do a good job of innovation in the way of thinking, innovative supervision methods and teaching methods, make full use of the advantages of the network, establish a teaching resource database, and improve the security of data information. The purpose of this article is to give full play to the advantages of computer network applications and to improve the applicability and effectiveness of the college English teaching model.
The Application of Art Design Thinking in Visual Works from the Perspective of Digital Media
Authors: Wang Xiaoyan , Zhang Yanhua 
Published: October 2020

Abstract
In the process of rapid development of information technology, the development speed of the information age is also relatively fast. In the information age, digital media has influenced modern design art to a certain extent. In the process of continuous development of media technology, visual works have developed and progressed significantly in terms of space. Because art has a crucial position in the design process of modern works. Therefore, we are supposed to study and analyze the application of art design thinking in visual works in the field of digital media, and explore the positive role of art in the design process of works. It is proposed that the application of artistic thinking in the design of works has a positive significance in enhancing the application effect of artistic design thinking.
The Application of Cloud Computing in the Practice Teaching of Business English Major in Higher Vocational Colleges
Authors: Mei Zhao 
Published: October 2020

Abstract
With the rapid development of information technology, cloud computing is also gradually applied to business English teaching practice in higher vocational education. Cloud computing can build a broad training platform for students, extend students’ English knowledge, and also meet the practical training needs of business English students, greatly improving the efficiency of business English teaching in vocational colleges. The effective connection between cloud computing and business English practice teaching meets the requirements of quality education, so higher vocational colleges should pay attention to it. This article analyzes the overview of cloud computing, explores the current status of business English teaching, and proposes strategies for cloud computing applications.
Research on career success of computer information technology research and development (R&D) personnel
Authors: Li Xuemei , Chen Yiwen , Zhang Yuting 
Published: October 2020

Abstract
To explore the influence mechanism of psychological capital on career success, a questionnaire survey was conducted among 288 research and development (R&D) personnel of computer information technology in China. The results showed that psychological capital, career commitment, person-organization fit, total score and each dimension of career success were significantly positively correlated with each other; psychological capital significantly positively predicts objective and subjective career success, and the predictive effect of both can be realized through the mediating role of career commitment; in the second half of the mediated path between psychological capital and subjective career success, career commitment is regulated by person-organization fit. Compared with individuals with a low level of person-organization fit, individuals with a high level of person-organization fit have a stronger mediating effect on the relationship between psychological capital and subjective career success.
Lightweight Crowd Counting Network based on Depthwise Separable Convolution
Authors: Yao Dengguo , Xu Yuanping , Zhang Chaolong , Xu Zhijie , Huang Jian , Guo Benjun 
Published: October 2020

Abstract
Crowd counting on the image is a challenging problem. Many neural network-based methods usually use two-branch and multi-branch networks to extract high-level features of different scales or densities, and then merge these features by a fusion operation. Although these methods can reduce the error of crowd counting, it makes the amount of parameters is enormous, so that the efficiency of training and optimization of the model is low, and the calculation resource consumption is high. To this end, a residual network based on depthwise separable convolution is proposed for image crowd counting. The network can not only reduce the amount of calculation through depthwise separable convolution, but also deepen the network depth through the residual structure to extract more effective high-level features. The experiment proves that, compared with the start-of-the-art methods, the method in this paper dramatically reduces the parameter amount to 1.91 Million when the accuracy is comparable.