bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic Evaluation of Percutaneous Titanium Implants for Bone Conduction Hearing: A Cost-benefit Analysis
Authors: Kruyt Ivo J. , Bours Marcel R. W. , Rovers Maroeska M. , Hol Myrthe K. S. , Rongen Jan 
Published: January 2020

Introduction:
Developments in bone-anchored hearing implants have resulted in fewer complications, and, thus, lower complication-related costs. However, a weighing of the potential clinical benefits with higher implant purchase price is lacking.

Methods:
A mathematical Markov model was used to evaluate the total costs (complication costs, implant purchase price, and standard costs) of three widely used current generation implants with expected similar outcomes, compared to a previous generation implant in adult patients over a 10-year time horizon from a healthcare perspective. Parameter estimates were derived from published clinical literature. Missing parameter estimates were based on expert opinion. Implant costs were derived from manufacturer catalogues, while standard and complication costs related to the BAHI were derived from a Dutch University Hospital and Dutch guideline for cost-effectiveness research.

Results:
The average total costs of the treatment with a previous generation implant was €4.967 (SD ± €134) per patient over a 10-year time horizon, compared to €4.678 (SD ± €83) with a current generation implant. This implant type is potentially up to €506 more beneficial per patient over a 10-year horizon. By further improving implant survival, an additional €645 (SD ± €86) per patient could be saved over 10 years.

Conclusion:
Despite a higher initial purchase price, the current generation implants are potentially cost-beneficial compared with previous generation implants. More data on current generation implants is needed to be able to determine which of the newer implants is most cost-beneficial. Focussing future developments on improving implant survival is likely to have more impact on costs compared with developments on improving soft tissue tolerability.
The gastrointestinal system in the critically ill cirrhotic patient
Authors: Olson Jody C. 
Published: January 2020

Purpose of review
ICU admissions due to complications of advanced liver disease continue to rise. Among indications for admission to the ICU in patients with cirrhosis, gastrointestinal issues such as bleeding are common. In patients in whom gastrointestinal issues are not the principal indication for ICU, gastrointestinal issues such as nutrition and ileus remain important concerns for generalized intensive care support. This review highlights current trends in management of gastrointestinal issues in patients with cirrhosis admitted to the ICU.

Recent findings
General management of upper gastrointestinal bleeding remains largely unchanged. Improvements in interventional techniques have increased the options for difficult to control bleeding, these include the development of expandable esophageal stents and expanded experience with advanced interventional radiology techniques for the management of bleeding gastric varices. Frailty as an important prognostic marker in advanced liver disease and liver transplantation is the subject of several new studies and serves to highlight the importance of nutrition in the management of the critically ill cirrhotic patient.

Summary
Gastrointestinal complications are frequent in the critically ill cirrhotic patient. Recognition and intervention in a timely manner may minimize morbidity and mortality and result in improved outcomes for this vulnerable population.
Nutrition intake in the post-ICU hospitalization period
Authors: Ridley Emma J. , Chapple Lee-anne S. , Chapman Marianne J. 
Published: January 2020

Purpose of reviewThe care of critically ill patients has evolved over recent years, resulting in significant reductions in mortality in developed countries; sometimes with prolonged issues with recovery. Nutrition research has focused on the early, acute period of critical illness, until more recently, where the post-ICU hospitalization period in critical care survivors has become a focus for nutrition rehabilitation. In this period, nutrition rehabilitation may be a vital component of recovery.Recent findingsOverall, oral nutrition is the most common mode of nutrition provision in the post-ICU period. Compared with oral intake alone, calorie and protein requirements can be better met with the addition of oral supplements and/or enteral nutrition to oral intake. However, calorie and protein intake remains below predicted targets in the post-ICU hospitalization period. Achieving nutrition targets are complex and multifactorial, but can primarily be grouped into three main areas: patient factors; clinician factors; and system factors.SummaryA nutrition intervention in the post-ICU hospitalization period may provide an opportunity to improve survival and functional recovery. However, there are multiple barriers to the delivery of calculated nutrition requirements in this period, a limited understanding of how this can be improved and how this translates into clinical benefit.
Heat-sensitive moxibustion for anaphylactic rhinitis
Authors: Xiong Jun , Yang Jun , Yuan Ting , Wang Xue , Jiang Yunfeng , Zhou Xiaohong , Liao Kai , Xu Lingling 
Published: January 2020

Abstract

Background
Anaphylactic rhinitis (AR) is one of the most common allergic disorders globally. Heat-sensitive moxibustion (HSM) is an effective method for AR without the occurrence of drug damage. This study aims to systematically investigate the effectiveness and safety of HSM for patients with AR.

Methods
Seven relevant electronic databases from inception until January 2020 including PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure Database, Wanfang Database, Chinese Biomedical Literature Database, and Chinese Scientific Journal Database will be searched. All relevant randomized clinical trials published in English and Chinese about HSM for AR regardless of blinding or publication types can be included. The Cochrane Central Register of Controlled Trials and other potential articles in the reference list of included studies will also be searched. We recommend total nasal symptom score as primary outcomes. Secondary outcomes includes rhinoconjunctivitis quality of life questionnaire, IgE, visual analogue scale, laboratory examination, and side effects. Study selection, data extraction, and quality assessment will be performed independently by 2 reviewers. Assessment of risk of bias and data synthesis will be conducted by RevMan 5.3 software.

Ethics and dissemination
Ethical approval is not required for no personal data involved. The results of this SR will be disseminated through peer-reviewed publications according to the Preferred Reporting Items for Systematic reviews and Meta Analysis Protocols guidelines.

Results
The results will be published in a peer-reviewed journal.

Conclusion
The findings will provide further evidence for the management of AR.

PROSPERO registration number
CRD42019140723.
The postoperative hepatic artery resistance index after living donor liver transplantation can predict early allograft dysfunction
Authors: Lv Tao , Kong LingXiang , Yang Jiayin , Wu Hong , Wen Tianfu , Jiang Li , Yang Jian 
Published: January 2020

Abstract
To investigate whether postoperative hepatic hemodynamics have an impact on graft function.
Using a retrospective cohort with 262 adult living donor liver transplantation (LDLT) recipients, we discussed the relationship between postoperative hepatic hemodynamics and patient outcomes.
According to the definition of early allograft dysfunction (EAD), the patients were classified into the EAD group (43 patients) and the non-EAD group (219 patients). In terms of postoperative hemodynamic parameters, there was no significant differences between these 2 groups regarding hepatic artery flow (HAF), hepatic artery velocity (HAV), portal vein flow (PVF), and portal vein velocity (PVV), except for the hepatic artery resistance index (HARI) which was somewhat higher in the EAD group on postoperative day 3 (POD3) (0.70 vs 0.61, P < .05). According to these results, we used a ROC curve and found that a HARI of 0.68 was the cutoff point (with 73.8% sensitivity and 58.3% specificity) for predicting EAD after LDLT. In addition, multivariate analysis showed that fulminant hepatic failure, pretransplant hepatorenal syndrome, and HARI ≥ 0.68 on POD3 were independent risk factors for postoperative EAD.
Our results showed that postoperative hemodynamics might influence graft function by altering hepatic artery flow.
Exploring factors influencing whether residents participate in square dancing using social cognitive theory
Authors: Peng Feng , Yan Hongjia , Sharma Manoj , Liu Ying , Lu Ying , Zhu Shijie , Li Peiqian , Ren Nianyong , Li Ting , Zhao Yong 
Published: January 2020

Abstract
Physical inactivity is a worldwide public health problem, and it is a risk factor for several chronic diseases. Square dancing nightly may be an efficient way to promote physical activity among Chinese residents. This study aims to explore factors that affect resident participation in square dancing on the basis of social cognitive theory constructs (outcome expectations, outcome expectancies, self-efficacy, self-control, and environment) that may provide a scientific basis for designing interventions to promote physical activity in the future.
Forty squares near neighborhood communities in Chongqing were randomly selected. A sample of 1732 residents who came to these squares at 18:00–21:00 were interviewed using a social cognitive theory questionnaire jointly developed by researchers from Chongqing Medical University and Jackson State University.
Among 1732 respondents, 279 (16.1%) were male and 1457 (83.9%) were female. A total of 939 (54.2%) of the respondents were square dancers. The mean age of the dancers was 58.6 (SD = 9.1) years. Of the dancers, 825 (87.9%) danced at least 150 minutes every week, and 792 (84.2%) indicated that they had danced for more than 1 year. All the constructs of social cognitive theory were significantly different between residents whether they danced or not (P < .001 for all). Women (OR = 1.54, 95% CI: 1.03–2.31) were more likely to dance. Nonretired residents (OR = 0.53, 95% CI: 0.39–0.74) were less likely to dance. Residents with income of more than CNY 4000 per month were less likely to dance (OR = 0.44, 95% CI: 0.23–0.86). Residents with high self-efficacy (OR = 2.01, 95% CI: 1.81–2.22), and high self-control (OR = 1.26, 95% CI: 1.18–1.34) were more likely to dance.
This study provides salient implications for developing interventions to promote square dancing by using social cognitive theory. Gender, retirement, income, and self-efficacy would be the factors influencing whether residents participate in square dancing.
Multi-center, randomized, double-blind, placebo-controlled, exploratory study to evaluate the efficacy and safety of HAD-B1 for dose-finding in EGFR positive and locally advanced or metastatic NSCLC subjects who need Afatinib therapy
Authors: Park So-Jung , Kang Hwi-Joong , Jun Hyung-Joon , Shin Seong-Hoon , Yoo Hwa-Seung 
Published: January 2020

Abstract

Background:
In recent studies, afatinib, a second-generation inhibitor, showed superior outcomes, when compared to the first-generation of EGFR-tyrosine kinase inhibitors (TKIs), such as erlotinib and gefitinib, in patients with advanced non-small cell lung cancer (NSCLC) harboring mutations of epidermal growth factor receptor (EGFR). Patients who receive TKIs with a significant initial efficacy, inevitably experience an acquired resistance (AR) within 9 to 13 months. Traditional Korean medicine may have synergistic effects when combined with chemotherapy or radiotherapy. The purpose of this trial is to assess whether afatinib plus HAD-B1 improves disease control rates (DCRs) compared with afatinib alone and to evaluate the efficacy and safety of HAD-B1 for finding the proper dose.

Methods:
This is a randomized, double-blind, placebo-controlled, multi-center, therapeutic, exploratory clinical trial. This trial is designed to determine whether HAD-B1 combined with afatinib results in better DCRs with less toxicity than afatinib alone. A total of 66 NSCLC patients with EGFR mutations will be randomly assigned to treatment group 1 (afatinib 40 mg/day plus HAD-B1 972 mg), treatment group 2 (afatinib 40 mg/day plus HAD-B1 1944 mg) and a control group (afatinib 40 mg/day). Afatinib combined with HAD-B1 or with a placebo will be administered to the participants for 12 weeks. The primary endpoint is a comparison of the DCRs among groups. Secondary endpoints are comparisons of the complete response (CR) and the partial response (PR) to the treatment, the stability of the disease (SD), progression free survival (PFS), time to progression (TTP), and tumor marker (CEA, NSE) and WBC differential count (LMR, NLR) and natural killer cell activity and quality of life (QOL) among groups.

Discussion:
The results from this clinical trial will provide evidence of efficacy and safety of HAD-B1 in EGFR positive and locally advanced or metastatic NSCLC patients who need afatinib therapy.
The efficacy and safety of Xuebijing injection as an adjunctive treatment for acute pancreatitis
Authors: Tang Qilin , Tian Lixin , Gao Chao , Zhang Kai , Su Nan , Liu Baohong , Zhai Jingbo , Liu Si , Li Yan 
Published: January 2020

Abstract

Background:
Acute pancreatitis (AP) is one of the common diseases with increasing incidence in clinical surgery and other gastrointestinal-digestive departments. Despite the rapid development of modern medicine, the overall mortality rate of AP is still high. Xuebijing (XBJ) injection (a traditional Chinese patent medicine) is a potentially effective drug for AP. This study is designed to assess the efficacy and safety of XBJ injection for AP.

Methods:
We will extract data and assess methodological quality of included studies from 7 electronic databases from their inception to December 31, 2019. The primary outcomes include the mortality, surgical intervention, systemic inflammatory response syndrome (SIRS), local complications, systemic infections, gastrointestinal symptoms, and normal blood amylase recovery time. The statistical analysis will be performed using RevMan 5.3 software.

Results:
This study will provide high-quality evidence for the efficacy of XBJ injection as an adjuvant therapy for AP.

Conclusion:
The study will provide the key evidence for clinical doctors and the development of clinical guidelines.
Severe peripheral arterial diseases in hemodialysis patient
Authors: Li Jiali , Yan Mingming , Qin Jiao , Liu Jun , Wen Rui 
Published: January 2020

Abstract

Rationale:
Peripheral arterial diseases (PADs) is defined as a systemic arterial disorders involving the lower extremity arteries, iliac, and carotid, which is developed more common in patients with chronic kidney disease (CKD) than individual with normal renal function. Concurrence of mesenteric artery disease and lower extremity artery disease (LEAD) is rare. The presence of PADs in patients receiving hemodialysis leads to a dramatic increase in risk of cardiovascular mortality. However, the early diagnosis of PADs in patient with CKD remains a challenge to nephrologists, which adds an adverse effect on prognosis.

Patient concerns:
A 48-year-old man received regular hemodialysis due to end-stage renal failure caused by type 2 diabetes mellitus (T2DM) for 7 years, who was admitted into hospital for acute, severe rest pain of the right lower extremity at the first time. The computed tomography angiography showed severe, diffuse stenosis of the distal third of femoral artery. After discharged, he was readmitted into hospital for abdominal pain and the recurred right lower limb pain. A diagnostic angiography confirmed the initial occlusion of superior mesenteric artery, severe obstruction of the distal segment of femoral artery and diffuse, irregular stenosis of arteria peronea and arteria tibialis posterior.

Diagnosis:
The patient was diagnosed as PADs including LEAD and mesenteric artery disease.

Interventions:
The percutaneous transulminal angioplasty (PTA) combined with antiplatelet therapy and beraprost were performed. Moreover, the cinacalcet and lanthanum carbonate were prescribed to control calcium-phosphorus- parathyroid hormone metabolism.

Outcomes:
The patient was free of abdominal pain and partly relieved from the ache of lower limb after PTA. However, he finally succumbed to acute myocardial infarction.

Lessons:
The incidence of PADs is higher in dialysis patients due to a unique set of biochemical and endocrine abnormalities. As there is a high uremic status and PADs burden in patients with hemodialysis, the short term risk of cardiovascular disesase mortality markedly increases. There is a need for nephrologists and cardiovascular physicians to identify these patients and then provide early and proper treatment.
Effectiveness of a multicomponent treatment versus conventional treatment in patients with fibromyalgia
Authors: Araya-Quintanilla Felipe , Gutiérrez-Espinoza Héctor , Muñoz-Yánez María Jesús , Cavero-Redondo Iván , Álvarez-Bueno Celia , Martinez-Vizcaíno Vicente 
Published: January 2020

Abstract

Background:
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain and multiple symptoms. It is a common clinical condition whose etiology is unclear. Currently, there is no gold standard treatment for FM. Management of this condition is therefore aimed at reducing symptoms and maintaining the individual's ability to function optimally. Based on the principal symptoms and characteristics of individuals with FM, we hypothesized that the implementation of a multicomponent treatment (with physical exercise, cognitive behavioral therapy adding to a graded motor imagery program, and therapeutic neuroscience education) would be more effective than conventional treatment in women with FM. This paper describes the rationale and methods of study intended to test the effectiveness of multicomponent treatment versus conventional treatment in patients with FM.

Method/Design:
Fifty-six female individuals between 18 and 65 years of age, who were referred to the physical therapy department of the Rehabilitar Center in Chile, will be randomized into two treatment arms. The intervention group will receive a multicomponent treatment program for duration of 12 weeks. The control group will receive a conventional treatment for this condition for 12 weeks. The primary outcome measure will be the pain intensity score, measured by the numeric pain rating scale (NPRS), and the secondary outcomes will be the FM Impact Questionnaire (FIQ), and affective components of pain, such as catastrophizing using the Pain Catastrophizing Scale (PCS), fear of movement using the Tampa Scale Kinesiophobia (TSK), and sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI).

Discussion:
This paper reports the design of a randomized clinical trial aimed at assessing the effectiveness of the multicomponent treatment versus conventional treatment in women with FM.

Trial registration:
Brazilian registry of clinical trials UTN number U1111-1232-0862. Registered 22 April 2019.
A systematic review and meta-analysis of the effects of early mobilization therapy in patients after cardiac surgery
Authors: Chen Bin , You Xiaofang , Lin Yuan , Dong Danyu , Xie Xuemin , Zheng Xinyi , Li Dong , Lin Wanqing 
Published: January 2020

Abstract

Background:
Prolonged hospitalization and immobility of critical care patients elevates the risk of long-term physical and cognitive impairments. However, the therapeutic effects of early mobilization have been difficult to interpret due to variations in study populations, interventions, and outcome measures. This systematic review and meta-analysis aims to assess the effects of early mobilization therapy for non-emergency cardiac surgery patients in the intensive care unit (ICU).

Methods:
The following databases will be used to search for relevant keywords: PubMed, Embase, CINAHL, PEDro, and the Cochrane Library from inception to September 2018 by 2 researchers independently. Randomized controlled trials (RCTs), will be included if patients are adults (≥18 years) admitted to any ICU for cardiac surgery due to cardiovascular disease and who are treated with experimental physiotherapy initiated in the ICU (pre, post, or perioperative). The Review Manager 5.3 will be used for meta-analysis and the evidence level will be assessed by using the method for Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Continuous outcomes will be presented as the weighted mean difference (WMD) or standardized mean difference (SMD) with 95% confidence interval (CI), while dichotomous data will be expressed as relative risk (RR) with 95% CI. If the included studies have existing heterogeneity (P < 0.1), a random-effects model will be used. Otherwise, we will calculate using a fixed effects model.

Results:
This review will evaluate the effects of early mobilization on length of ICU and hospital stay, physical function and adverse events in patients with cardiac surgery patients in the ICU.

Conclusion:
This systematic review will comprehensively provide conclusive evidence of the therapeutic effect of early mobilization on cardiac surgery patients in the ICU.
PROSPERO Research registration identifying number: CRD42019135338.
Analysis of inpatients’ characteristics and spatio-temporal distribution of liver cancer incidence in Wuwei, Gansu Province, from 1995 to 2016
Authors: Zhang Yang , li Zhao , Shao Zhongjun , Liu Kun , Ji Zhaohua 
Published: January 2020

Abstract
This long-term span retrospective study aimed to determine the incidence and spatial-temporal trends of liver cancer in Wuwei city from 1995 to 2016 to provide scientific knowledge on the prevention and treatment of liver cancer.
Data from the medical records of liver cancer patients treated in 12 sentinel hospitals in Wuwei city were extracted. SAS and Joinpoint software were used for data analysis, ArcGIS 10.2 software was used to make geographical distribution map, and SaTScan 9.4 software was used for clustering area detection.
Of 2271 patients with liver cancer (average age, 58.73 years), 17.7% were 60 to 64 years of age. Majority were males (1680, 74%), with a sex ratio of 2.84. Joinpoint regression analysis from 1995 to 2016 revealed that the standardized liver cancer rate increased [annual average rate of change (AAPC) = 12.80% (95% CI: 9.5%–16.7%)], with a joinpoint in 2009. From 1995 to 2009, the change in overall APC was statistically significant [APC = 16.7 (95% CI: 12.3%–21.3%)]. The average incidence was the highest in Hongshagang Town. After 2005, the incidence gradually increased in each township. Five clusters of liver cancer were noted in Wuwei, including 37 townships.
Males had a higher standardized liver cancer rate. After 2009, increase in the incidence of liver cancer was less rapid. The incidence of liver cancer in townships of Wuwei city was non-random, with certain spatial aggregations, covering 37 townships.