bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF THERAPEUTIC GROUP THERAPY ON THE DEVELOPMENT OF ADOLESCENT SELF IDENTITY IN ORPHANAGE
Authors: Kholifah Siti , Margono Hendy Muagiri , Fitryasari Rizki , , Ah Yusuf , Endang Hanik , , Budiono 
Published: July 2020

Introduction: Adolescents living in orphanages experience a lack of self-confidence, withdrawal, lack of interest in learning, lack of communication, and a closed attitude so that it will have a negative impact on cognitive, emotional, and social development. This study aims to determine the effect of Therapeutic Group Therapy (TKT) on the development of adolescent self-identity in orphanages. Methods : The study design was a Quasy experimental pre-post test control group design. The population was 104 children living in orphanages A and B. The research sample was 30 intervention groups and 32 control groups that met the inclusion criteria obtained through purposive sampling. The independent variable is Therapeutic Group Therapy while the dependent variable is self-identity. Data obtained using a questionnaire and analyzed using the Wilcoxon Sign Ranks Test and Mann-Whitney U Test with a significance level ∝ <0.05. Results : The results of the analysis of the intervention group showed the effect of TKT on self-identity (p = 0.0001). The results of the Mann-Whitney U Statistical Test of self-identity test showed a value of p = 0,0001 ( ∝ <0.05) meaning that there was an effect of TKT on self-identity between the two groups. Conclusion : TKT is done by health workers can help identify identity status teenagers and can improve self-identity teenager who lived in the orphanage through health education.
Assessment of the Magnetic Resonance Imaging Features of Baker’s Cysts and Their Correlation with the Age of Patients
Authors: Chernyad’ev S. A. , Aretinskiy V. B. , Sivkova N. I. , Zhilyakov A. V. , Korobova N. Yu. , Blinov V. S. , Grebenev E. A. 
Published: July 2020

Objective. To determine the magnetic resonance imaging (MRI) morphological features of Baker’s cysts and to assess their correlation with the age of patients.Material and methods. The investigation was based on the assessment of MRI readings in 37 patients with Baker’s cysts; of them there were 29 (78.4%) women and 8 (21.6%) men. The mean age of the examinees was 60.3 years (25 to 82 years).Results. The mean dimensions of the cysts were measured. Their length, width, and height were 34 ± 2.1 mm, 5 ± 1.2 mm (range 4–31 mm), and 58 ± 2.9 mm, respectively. Their mean thickness was 0.7 mm. Intracystic chondral bodies were detected in 3 (7.5%) cases. These parameters were shown to be unrelated to age. It was found that all cysts were multi-chamber and an average of 6.8 chambers was detected. There was a weak, inversely proportional, statistically significant relationship between the age of the patients and the number of chambers in the cyst. The younger participants of the investigation exhibited no meniscal damage in an overwhelming case (57.1%); whereas complete and incomplete meniscal tears much more often occurred in older patients with Baker’s cysts (from 29 (78.4%) to 34 (91.9%) people, respectively).Conclusion. Degenerative bone and cartilage tissue changes in the joint increase with age, regardless of the cyst sizes.
Detectability of Brain Arteriovenous Malformations with CT Angiography in the Chuvash Republic
Authors: Mikhaylova M. N. , Kostrova O. Yu. , Merkulova L. M. , Struchko G. Yu. , Semenov A. Yu. 
Published: July 2020

Objective. To estimate the detection rate of brain arteriovenous malformations (AVMs) in the Chuvash Republic and their characteristics.Material and methods. The results of CT angiographies performed at the Unit of Radiation Diagnosis in 2014–2017 were retrospectively analyzed.Results. Over 4 years, brain AVMs were first detected in 29 patients (5–9 cases per year); of them 59% were men and 41% were women. The peak detectability occurred at the age of 31–40 years. AVMs were more frequently localized in the frontal and temporal regions. The high risk of surgery for AVMs according to the grading scheme by R. Spetzler and N. Martin (1986) occurred in 10% of cases. Besides AVMs, cerebral vascular aneurysms were detected in 14% of patients.Conclusion. Small AVMs with a low risk of surgery are more common; however, there is a higher risk of hemorrhagic complications. The risk of cerebral hemorrhage is higher when AVMs are fed by the internal carotid arteries and drained into the deep veins. The likelihood of strokes in AVMs is 27% higher in patients with the open circle of Willis.
Metabolic Pathways Underpinning Lymphocyte Differentiation and Responses in Health and Disease
Authors: Bystrom Jonas , Taher Taher E. , Mageed Rizgar A. 
Published: July 2020

AbstractLymphocytes mount protective immunity from infectious pathogens and from cancer. Their engagement by target antigens prompt activation, differentiation to effector cells and proliferation. These responses require energy that is generated by cellular metabolic processes, such as glycolysis and oxidative phosphorylation. Glycolysis occurs in the cytoplasm while oxidative phosphorylation occurs in the mitochondria. Energy in the form of adenosine triphosphate is generated from the uptake of glucose, amino acids and free fatty acids. Important recent evidence indicates that naïve and activated lymphocytes and functionally distinct subsets preferentially use different metabolic pathways for their energy needs. Thus, effector Th17 cells primarily use glycolysis to generate energy required for their activities. Memory T and B cells and regulatory T cells, in contrast, rely on mitochondrial metabolism for their energy requirements. Naïve T and B are in a quiescent state with small mitochondria. Extrinsic factors such as oxygen tension and intrinsic substrates can also influence the choice of metabolic pathways and functional flexibility. Studies of lymphocytes in disease states reveal alterations to choices of metabolic pathways from those in lymphocytes in healthy individuals. This article provides an overview of metabolic pathways required for energy generation during homeostasis and those induced during cellular differentiation and responses. Furthermore, we explore available evidence for altered metabolic pathway induction in some autoimmune diseases. A focus of the overview will be on helper T lymphocytes involved in chronic inflammation and those that regulate the immune response. The report alludes to the potential that targeting metabolic pathways could provide a strategy for the treatment of chronic diseases.
Skeletal Muscle Metastases from Carcinomas
Authors: Pretell-Mazzini Juan , Younis Manaf H. , Subhawong Ty 
Published: July 2020

» Bones are a common site for metastases; however, muscle metastases recently have been more commonly reported, not only as a result of the multidisciplinary approach in the treatment of these patients but also because of more sensitive imaging modalities such as positron emission tomography-computed tomography (PET-CT) that identify these lesions in early stages.» The most common carcinoma is lung carcinoma, with a hematogenous route of spread mainly to the axial region of the body (the psoas muscle, the gluteal muscles, and the paravertebral muscles).» Clinically, skeletal muscle metastases from carcinomas frequently present as painful palpable masses with or without swelling and are commonly found before diagnosis of the primary carcinoma.» Multiple imaging modalities, including radiographs, CT, magnetic resonance imaging (MRI), and PET-CT, have been used for diagnosis and staging, but tissue sampling is needed for a final diagnosis. The most important differential diagnosis of skeletal muscle metastases is with soft-tissue sarcomas.» Treatment is mainly based on chemotherapy and/or radiation; surgery is performed in cases of symptomatic lesions that fail to respond to nonoperative treatment.
Teknologi Pengolahan Samosa dengan Penambahan Daun Kelor (Moringa oleifera)
Authors: Widagdo Andika Kuncoro , Hamidah Siti 
Published: July 2020

<p>Daun kelor merupakan tanaman yang banyak ditemui di Indonesia. Tanaman ini mengandung banyak gizi, tetapi pemanfaatannya masih rendah. Agar gizi tersebut dapat dimanfaatkan maka perlu dilakukan inovasi makanan yang dapat diterima oleh masyarakat. Salah satu inovasi yang dipilih adalah samosa. Pemilihan hidangan tersebut dikarenakan rasa dari rempah dapat menutupi rasa dan aroma khas daun kelor. Penelitian dilaksanakan untuk mengetahui daya terima secara sensoris dan nilai gizi (energi dan ß-karoten) samosa. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan 6 kali pengulangan pada 4 formula. Formula kontrol (F0) dan 3 formula modifikasi (F1,F2, dan F3), samosa diujikan kepada 50 panelis tidak terlatih dengan penambahan kelor sebesar 17,5%; 20% dan 22,5%. Analisis data menggunakan analisis deskriptif dan analisis statistik menggunakan uji Kruskal Wallis dan Mann Whitney Test (a = 0,05). Analisis daya terima menunjukkan bahwa formula samosa daun kelor dapat diterima secara umum (rasa, aroma, tekstur, dan warna) dengan kategori suka (3) hanya pada formula F1 (penambahan daun kelor paling sedikit). Warna dan tekstur tidak berbeda nyata, sedangkan aroma berbeda nyata. Formula terbaik yang direkomendasikan yaitu F1 (daun kelor 17,5%) dengan kandungan zat gizi sebesar 164 kkal dan 604 mcg ß-karoten per 100 g.</p><p> </p><p><strong>Received Power and Samosa Nutrition Substance with Addition Of Moringa oliefera</strong></p><p>Moringa leaves are plant parts that are commonly found in Indonesia. This plant contains high nutrients, but its use is still limited. To utilize these nutrients, it is necessary to innovate a food that accepted by the communities. One of the food was samosa, the choice of the dish was due to the taste of the spices that able to cover the flavor and aroma typical of moringa leaves. This research was carried out to determine the sensory reception and nutritional value (energy and ß-carotene) of samosa. The study was conducted using a completely randomized design (CRD) with six replicates on four formulas. Control formula (F0) and three modified samosas recipes (F1, F2, and F3), were tested to 50 untrained panelist with the addition of moringa were 17,5%; 20% and 22.5%. Data analysis used descriptive analysis and statistical analysis using the Kruskal Wallis test and Mann Whitney Test (a = 0.05). Analysis of acceptability indicate that samosa with F1 formula (the least addition of moringa leaves) was generally accepted (taste, aroma, texture, and color) with the category of the likes (3), Color and texture were not significantly different mean while aroma was significantly different. The best formula recommended is F1 (17,5% moringa leaves) with nutrient content of 164 kcal and 604 mcg ß-carotene per 100 g of samosa.</p><p><strong><br /></strong></p>
Un teatro para la pandemia: alternativas para la creación escénica en tiempos del nuevo coronavirus en el Perú, a propósito del proyecto virtual «Sin filtro» del Teatro Británico
Authors: Barraza Eléspuru Ernesto 
Published: July 2020

Este artículo centra su análisis en el proyecto «Sin filtro», impulsado por el Teatro Británico en Lima, como respuesta a la crisis del sector de las artes escénicas en el Perú, en el marco de la emergencia nacional por la COVID-19 que se inició el 16 de marzo de 2020 y que se ha mantenido durante el desarrollo de la presente investigación. El artículo toma como objeto de análisis las cuatro obras que se escribieron y produjeron como parte de la primera etapa del proyecto.
De esta manera, se busca reflexionar, describir y analizar los factores de un nuevo proceso creativo, a propósito del mencionado proyecto, y se intenta indagar hasta qué punto es posible la creación escénica a través de un soporte virtual, como respuesta a un contexto que ha obligado a cerrar la totalidad de los teatros en el mundo y ha dejado al sector casi totalmente en el desempleo.
The association between nutrient intake, nutritional status and physical function of community-dwelling ethnically diverse older adults
Authors: Asamane Evans Atiah , Greig Carolyn A. , Thompson Janice Lee 
Published: July 2020

Abstract
Background: There are limited longitudinal data regarding nutrient intake, nutritional status and physical function in community-dwelling ethnically diverse older adults. This study explored these variables and their relationship at baseline (n=100) and 8-months’ follow-up (n=81) among community-dwelling ethnically diverse older adults (≥60 years) in Birmingham, United Kingdom. Methods: Multiple-pass 24-hour dietary recalls and the Mini Nutritional Assessment-Short Form assessed nutritional intake and status, respectively. Short Physical Performance Battery (SPPB) and handgrip strength measured physical function. Linear and multinomial regressions were used to predict relationships between physical function, nutritional status and nutrient intake. Results: Complete data were collected at baseline (n=100) and 8-months’ follow-up (n=81). Mean (SD) age was 70 (8.1) years (60% male), with 62% being obese. Statistically significant decreases in intakes of vitamin B6, vitamin B1, iron, folate, and magnesium occurred over time. Daily intake of all micronutrients except vitamin B12, phosphorus and manganese were below the Recommended Nutrient Intakes (RNI). SPPB (Z=-4.01, p<0.001) and nutritional status (Z=-2.37, p=0.018) declined over time. Higher SPPB scores at baseline (OR=0.54 95% CI 0.35, 0.81) were associated with a slower decline in nutritional status. Conclusion: The observed declines and inadequate nutrient intakes in the absence of weight loss in just eight months may pose serious challenges to healthy ageing, identifying an urgent need to re-evaluate and tailor appropriate dietary advice for this population. Additionally, the associations of nutrition and physical function observed in this study serves as an essential resource to design and implement community/faith-based interventions targeting early screening of nutritional status and physical function to ensure most older adults are assessed and treated accordingly.
Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network
Authors: Wang Zhen , Liu Zhongjie , Liu Yingxia , Kang Lei 
Published: July 2020

Abstract
Background

Hypertensive nephropathy (HTN) is a kind of renal injury caused by chronic hypertension, which seriously affect people’s life. The purpose of this study was to identify the potential biomarkers of HTN and understand its possible mechanisms.

Methods

The dataset numbered GSE28260 related to hypertensive and normotensive was downloaded from NCBI Gene Expression Omnibus. Then, the differentially expressed RNAs (DERs) were screened using R limma package, and functional analyses of DE-mRNA were performed by DAVID. Afterwards, a ceRNA network was established and KEGG pathway was analyzed based on the Gene Set Enrichment Analysis (GSEA) database. Finally, a ceRNA regulatory network directly associated with HTN was proposed.

Results

A total of 947 DERs were identified, including 900 DE-mRNAs, 20 DE-lncRNAs and 27 DE-miRNAs. Based on these DE-mRNAs, they were involved in biological processes such as fatty acid beta-oxidation, IRE1-mediated unfolded protein response, and transmembrane transport, and many KEGG pathways like glycine, serine and threonine metabolism, carbon metabolism. Subsequently, lncRNAs KCTD21-AS1 , LINC00470 and SNHG14 were found to be hub nodes in the ceRNA regulatory network. KEGG analysis showed that insulin signaling pathway, glycine, serine and threonine metabolism, pathways in cancer, lysosome, and apoptosis was associated with hypertensive. Finally, insulin signaling pathway was screened to directly associate with HTN and was regulated by mRNAs PPP1R3C , PPKAR2B and AKT3 , miRNA has-miR-107, and lncRNAs SNHG14 , TUG1 , ZNF252P-AS1 and MIR503HG .

Conclusions

Insulin signaling pathway was directly associated with HTN, and miRNA has-miR-107 and lncRNAs SNHG14 , TUG1 , ZNF252P-AS1 and MIR503HG were the biomarkers of HTN. These results would improve our understanding of the occurrence and development of HTN.
Quantitative assessment of neural elements in a rat model using nerve growth factor after remnant-preserving anterior cruciate ligament reconstruction: a histological and immunofluorescence pilot study
Authors: Lee Sung Hyun , Cho Hyung Gyu , Song Jin Soo , Chun Keun Churl , Chun Churl Hong 
Published: July 2020

Abstract
Background: Immunofluorescence analyses of anterior cruciate ligament (ACL) allografts following remnant-preserving ACL reconstruction using Achilles tendon allografts have provided evidence for the presence of neural elements. In this study, we aimed to examine the expression of neural elements and quantify the presence of neural cells in ACL remnants and Achilles allografts using nerve growth factor (NGF) therapy after remnant-preserving ACL reconstruction.Methods: Experiments were conducted on 5 pairs of rats (approximately 8 weeks old and weighing 320 g at the time of surgery). Longitudinally split Achilles tendons from the paired rats were freshly frozen and later defrosted with warm saline and allografted onto the right ACL of the other rat that was partially detached at the femoral attachment site. A sham operation was conducted on the left knee to be used as a control. NGF was injected into both knee joints every week for 6 weeks after surgery. The presence of neural cells in the ACL of the sham-operated knee, allografted Achilles tendon, and ACL remnant was examined 6 weeks post-surgery using H and E and immunofluorescent staining.Results: H and E staining did not reveal neural cells in any of the three groups. However, immunofluorescence analysis showed the presence of nestin-positive neural elements in the normal ACL tissues as well as ACL remnants. Additionally, neural elements were examined in 7 of the 8 (87.5%) allograft tissues. Quantitative analysis showed no difference in the number or area of nuclei among the three groups. However, the number and area of neural cells in the Achilles allografts were significantly lower than those in the other two groups (p=0.000 and p=0.001, respectively).Conclusion: Our observations indicate that ACL remnants promote the new ingrowth and persistence of neural cells. We suggest that the ingrowth of neural elements can support the persistence and new ingrowth of mechanoreceptors, thereby enhancing the functional stability of knee joints. Moreover, the expression of neural cells in the Achilles allografts was lower than that in normal ACL tissues and ACL remnants in the quantitative evaluation, thereby confirming the essential role of ACL remnants in knee joint functionalization.
A Five-Year Trend Analysis of Malaria Surveillance Data in Selected Zones of Amhara Region, Northwest Ethiopia
Authors: Lankir Damtie , Solomn Samrawit , Gize Addisu 
Published: July 2020

Abstract
Background : Trend analysis of malaria surveillance data is essential to inform stakeholders on progress towards malaria control. From the total 387,096 cases of malaria reported in Amhara region in 2017, 167,079 (43.2%) cases were in Central, North and West Gondar zones. From this total figure of zones, 15,445 (9.2%) were ≤5 years which contributes 4 % of cases in the region. So, the purpose of this study was to analyze trends of malaria parasite in Selected Zones of Amhara Region, Northwest Ethiopia Methods : A Retrospective study was conducted in Central, North and West Gondar zones from July 1- 30/ 2018. Data were collected, entered, cleaned, analyzed and interpreted using Microsoft Excel-2010. Different tables, figures and maps were used to present results. Result : A total of 2,827,722 cases have been received a diagnostic test of; Microscopy 1,712,193(60.56%) and Rapid Diagnostic Test (RDT) 1,115,529(39.44%). Trends of total patients treated as confirmed and clinical malaria cases in July 2017- June 2018 were decreased to 139297 (14%) as compared from July 2015- June 2016, 249571(25%). From total cases received diagnostic tests only 1,003,391 (36%) were confirmed and clinical cases treated with antimalaria. Of these Plasmodium falciparum and vivax malaria cases were confirmed to be 1,002,946 (99.96%) and clinical malaria cases were 445(0.04%), respectively. Conclusion : Risk of infection and diagnostic effort were high in West Gondar Zone. The Amhara public health institute including health Bureau, stakeholders and all responsible bodies should give special standing to highest malaria districts of West Gondar zone.
Active constituents of Zanthoxylum nitidum from Yunnan Province against leukemia
Authors: Deng Ying , Ding Tongtong , Deng Lulu , Hao Xiaojiang , Mu Shu Zhen 
Published: July 2020

Abstract
Zanthoxylum nitidium (Roxb.) DC (Rutaceae) is well known for inhibiting the proliferation of human gastric, liver, kidney and lung cancer cells, though research on its potential use in treating leukaemia is relatively rare. Twenty-six compounds were isolated from the chloroform and petroleum ether extracts of the roots and leaves of Z. nitidium . Four among them, compounds 4-6 and 16 , were first confirmed in this study by UV, IR, 1D, 2D NMR and HR-ESI-MS spectra. Compounds 1-2 and 11 were isolated from Z. nitidium for the first time. Of the assayed compounds, 1 , 2 , 9 , 10 , 14 , 15 and 24, exhibited good inhibitory activities in the leukaemia cell line HEL, whereas compound 14 (IC 50 : 3.59 µM) and compound 24 (IC 50 : 15.95 µM) exhibited potent inhibitory activities. So, to further investigate the possible mechanisms, cell cycle and apoptosis assays were performed, which indicated that compound 14 causes obvious S-phase arrest in HEL cells and induced apoptosis, whereas compound 24 only induced apoptosis. The present results suggested both compounds 14 and 24 are promising potential anti-leukaemia drug candidates.
Characterization, Identification and Expression Profiling of Genome-Wide R-Genes in Melon and Their Putative Roles in Bacterial Fruit Blotch Resistance
Authors: Islam Md. Rafiqul , Hossain Mohammad Rashed , Jesse Denison Michael Immanuel , Jung Hee-Jeong , Kim Hoy-Taek , Park Jong-In , Nou Ill-Sup 
Published: July 2020

Abstract
Background: Bacterial fruit blotch (BFB), a disease caused by Acidovorax citrulli, results in significant economic losses in melon. The causal QTLs and genes for resistance to this disease have yet to be identified. Resistance (R)-genes play vital roles in resistance to plant diseases. Since the complete genome sequence of melon is available and genome-wide identification of R-genes has been performed for this important crop, comprehensive expression profiling may lead to the identification of putative candidate genes that function in the response to BFB.Results: We identified melon accessions that are resistant and susceptible to BFB through repeated bioassays and characterized all 70 R-genes in melon, including their gene structures, chromosomal locations, domain organizations, motif distributions, and syntenic relationships. Several disease resistance-related domains were identified, including NBS, TIR, LRR, CC, RLK, and DUF domains, and the genes were categorized based on the domains of their encoded proteins. In addition, we profiled the expression patterns of the genes in melon accessions with contrasting levels of BFB resistance at 12 h, 1 d, 3 d, and 6 d after inoculation with A. citrulli. Six R-genes exhibited consistent expression patterns (MELO3C023441, MELO3C016529, MELO3C022157, MELO3C022146, MELO3C025518, and MELO3C004303), with higher expression levels in the resistant vs. susceptible accession. Conclusion: We identified six putative candidate R-genes against BFB in melon. Upon functional validation, these genes could be targeted for manipulation via breeding and biotechnological approaches to improve BFB resistance in melon in the future.