bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excitation of beta-induced Alfvén eigenmodes by the coupling between geodesic acoustic mode and magnetic island
Authors: Cai Huishan , Gao Baofeng , Xu Ming , Liu Adi , Kong Defeng 
Published: December 2020

Abstract
The mechanism of excitation of beta-induced Alfvén eigenmodes (BAEs) with magnetic islands larger than a threshold without energetic ions is studied. It is found that the nonlinear coupling between geodesic acoustic mode and magnetic islands can drive the pair of BAEs. The phase of BAEs to island should be π/2 to excite the BAEs and the magnetic island is larger than a threshold. The results are consistent with the experimental results shown in EAST(#86309). It implies that similar experimental results in other tokamaks, that BAEs excitation by magnetic islands without energetic ions, may be from the nonlinear coupling between islands and waves. It also implies that the existence of magnetic islands can make the excitation of BAEs easier in plasma with energetic ions, since the magnetic island can also increase the pressure gradient of energetic ions near the island separatrix. This predicts that BAEs may appear more frequently in the presence of magnetic islands in ITER.
POPX2 phosphatase enhances topographical contact guidance for cell morphology and migration
Authors: Sathe Sharvari R , Jain Deepak , Koh Cheng-Gee , Yim Evelyn K F 
Published: December 2020

Abstract
Topography mediated contact guidance affects multiple cell behaviors such as establishment of cellular morphology and migration. The direction of cell migration is associated with the establishment of cell polarity, which also affects the primary cilia in migrating cells. POPX2, a partner of PIX2, is involved in pathways essential to primary cilium formation, while over-expression of POPX2 has been reported to cause a loss of cell polarity during migration. This study aims to examine how topographical cues direct morphological changes, and how topography affects the process of cellular migration and primary cilium architecture, in the context of POPX2 over-expression. Thus, the effect of anisotropic topography, 2 μm grating pattern on tissue-culture polystyrene, was used as a contact guidance cue to investigate the migration and cell polarity of POPX2 overexpressing cells, in comparison to control NIH3T3 fibroblast cells. We report that POPX2 overexpressing NIH3T3 cells were more sensitive to surface topographical cues as the cells became more elongated. In addition, these cues also affected focal adhesion alignment of POPX2 overexpressing cells. Cell migration was further studied using wound closure assays, in which the 2 μm gratings were designed to be either perpendicular or parallel to wound-induced cell migration direction, which would be agonistic or antagonistic to cell migration, respectively. We observed that both POPX2 overexpressing cells’ migration direction and migration rate were more significantly influenced by gratings direction compared to control NIH3T3 cells. The migration paths of POPX2 overexpressing cells become more direct in the presence of anisotropic topographical cues. Further, cilia and centrosome alignment, which is important in cell migration, was also affected by the direction of gratings during this migration process. Collectively, enhancement of NIH3T3 cell sensitivity towards surface topography through POPX2 overexpression might reflect one of the mechanisms that combine biochemical and mechanical cues for directional cell migration.
COVID-19 lockdown only partially alleviates health impacts of air pollution in Northern Italy
Authors: Granella Francesco , Aleluia Reis Lara , Bosetti Valentina , Tavoni Massimo 
Published: December 2020

Abstract
Evaluating the reduction in pollution caused by a sudden change in emissions is complicated by the confounding effect of weather variations. We propose an approach based on machine learning to build counterfactual scenarios that address the effect of weather and apply it to the COVID-19 lockdown of Lombardy, Italy. We show that the lockdown reduced background concentrations of PM2.5 by 3.84 µg m−3 (16%) and NO2 by 10.85 µg m−3 (33%). Improvement in air quality saved at least 11% of the years of life lost and 19% of the premature deaths attributable to COVID-19 in the region during the same period. The analysis highlights the benefits of improving air quality and the need for an integrated policy response addressing the full diversity of emission sources.
Moiré and beyond in transition metal dichalcogenide twisted bilayers
Authors: Tran Kha , Choi Junho , Singh Akshay 
Published: December 2020

Abstract
Fabricating van der Waals bilayer heterostructures (BL-HS) by stacking the same or different two-dimensional layers, offers a unique physical system with rich electronic and optical properties. Twist-angle between component layers has emerged as a remarkable parameter that can control the period of lateral confinement, and nature of the exciton (Coulomb bound electron–hole pair) in reciprocal space thus creating exotic physical states including moiré excitons (MXs). In this review article, we focus on opto-electronic properties of excitons in transition metal dichalcogenide semiconductor twisted BL-HS. We look at existing evidence of MXs in localized and strongly correlated states, and at nanoscale mapping of moiré superlattice and lattice-reconstruction. This review will be helpful in guiding the community as well as motivating work in areas such as near-field optical measurements and controlling the creation of novel physical states.
A new approach to study nonlinear space-time fractional sine-Gordon and Burgers equations
Authors: Roy Ripan , Akbar M. Ali 
Published: December 2020

Abstract
In this study, we investigate a couple of nonlinear fractional differential equations namely, the sine-Gordon and Burgers equations in the sense of Riemann-Liouville fractional derivative. In order to examine exact solutions effectively applicable in relaxation and diffusion problems, crystal defects, solid-state physics, plasma physics, vibration theory, astrophysical fusion plasmas, scalar electrodynamics, etc. we introduce the new generalized

G
′
/
G

-expansion method. The method is highly effective and a functional mathematical scheme to examine solitary wave solutions to diverse fractional physical models.
Managing Corpses From Different Castes in the Eastern Subterranean Termite
Authors: Shi Jizhe , Zhang Chi , Huang Sirui , Merchant Austin , Sun Qian , Zhou Chuan , Haynes Kenneth F , Zhou Xuguo 
Published: December 2020

Abstract
Corpse management is essential for social animals to maintain colony health. In the eastern subterranean termite, Reticulitermes flavipes, workers carry out undertaking behaviors to mitigate the risks associated with the dead. In this study, we hypothesized that termites would respond differently to the corpses from different castes based on their postmortem chemical signatures. To test this hypothesis, we 1) documented the behavioral responses of the workers toward corpses from different castes, and 2) profile the chemical signatures of these corpses. Corpses from all castes were retrieved inside the nests and cannibalized when they were decomposed &lt;64 h, regardless of the presence or absence of the cues that we refer to as early death cues (3-octanol and 3-octanone). However, after 64 h, all corpses except for soldiers were buried on site by R. flavipes workers. The late death cues (oleic acid) were cumulative over time among castes but accumulated more slowly and at lower levels in soldiers. The differential release of 3-octanol and 3-octanone between workers/soldiers and nymphs could be explained by either qualitative or quantitative differences in signaling the death between imaginal and neuter developmental pathways. In summary, the efficient and selective recognition of the dead and the fine-tuning of subsequent undertaking responses observed in R. flavipes are aspects of corpse management, which can minimize the potential risks associated with different castes and maximize the colony fitness.
Does Advice Based on Biomarkers of Liver Injury or Non-Invasive Tests of Liver Fibrosis Impact High-Risk Drinking Behaviour: A Systematic Review With Meta-analysis
Authors: Subhani Mohsan , Knight Holly , Ryder Stephen , Morling Joanne R 
Published: December 2020

Abstract

Background and Aims
Alcohol dependence affects over 240 million people worldwide and attributed to 3 million deaths annually. Early identification and intervention are key to prevent harm. We aim to systematically review literature on the effectiveness of adding advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis (intervention-based advice) to prevent alcohol misuse.

Methods
Electronic search was conducted on Ovid Medline, PubMed, EMBASE, Psychinfo and CINAHL for articles published up to end of February 2020. Additionally, we searched study citations, Scopus, Ethos and Clinical trials. The primary outcome measure was changed in self-reported alcohol consumption analysed by random-effects meta-analysis. Secondary outcomes included change to liver blood markers and alcohol-related health outcomes.

Results
Fourteen randomized controlled trials (RCTs) and two observational studies comprising n = 3763 participants were included. Meta-analyses showed a greater reduction in alcohol consumption and liver biomarkers for the intervention compared to control group: mean difference for weekly alcohol intake was −74.4 g/week (95% confidence interval (CI) −126.1, −22.6, P = 0.005) and mean difference for gamma-glutamyl transferase (GGT) −19.7 IU/l (95% CI −33.1, −6.4, P = 0.004). There was a higher incidence of alcohol-attributed mortality, number of days spent in the hospital, physician visits and sickness absence in the non-intervention group. The quality of the included studies was moderate for RCTs and high for observational studies.

Conclusions
The review confirmed a significant association between the addition of intervention-based advice in routine care to the reduction of harmful alcohol consumption, GGT and alcohol-related mortality. The findings support the inclusion of this type of advice in routine alcohol care.
Biomarkers of memory variability in traumatic brain injury
Authors: Adamovich-Zeitlin Richard , Wanda Paul A , Solomon Ethan , Phan Tung , Lega Bradley , Jobst Barbara C , Gross Robert E , Ding Kan , Diaz-Arrastia Ramon , Kahana Michael J 
Published: December 2020

Abstract
Traumatic brain injury is a leading cause of cognitive disability and is often associated with significant impairment in episodic memory. In traumatic brain injury survivors, as in healthy controls, there is marked variability between individuals in memory ability. Using recordings from indwelling electrodes, we characterized and compared the oscillatory biomarkers of mnemonic variability in two cohorts of epilepsy patients: a group with a history of moderate-to-severe traumatic brain injury (n = 37) and a group of controls without traumatic brain injury (n = 111) closely matched for demographics and electrode coverage. Analysis of these recordings demonstrated that increased high-frequency power and decreased theta power across a broad set of brain regions mark periods of successful memory formation in both groups. As features in a logistic-regression classifier, spectral power biomarkers effectively predicted recall probability, with little difference between traumatic brain injury patients and controls. The two groups also displayed similar patterns of theta-frequency connectivity during successful encoding periods. These biomarkers of successful memory, highly conserved between traumatic brain injury patients and controls, could serve as the basis for novel therapies that target disordered memory across diverse forms of neurological disease.
Working Memory for Signs with Poor Visual Resolution: fMRI Evidence of Reorganization of Auditory Cortex in Deaf Signers
Authors: Andin Josefine , Holmer Emil , Schönström Krister , Rudner Mary 
Published: December 2020

Abstract
Stimulus degradation adds to working memory load during speech processing. We investigated whether this applies to sign processing and, if so, whether the mechanism implicates secondary auditory cortex. We conducted an fMRI experiment where 16 deaf early signers (DES) and 22 hearing non-signers performed a sign-based n-back task with three load levels and stimuli presented at high and low resolution. We found decreased behavioral performance with increasing load and decreasing visual resolution, but the neurobiological mechanisms involved differed between the two manipulations and did so for both groups. Importantly, while the load manipulation was, as predicted, accompanied by activation in the frontoparietal working memory network, the resolution manipulation resulted in temporal and occipital activation. Furthermore, we found evidence of cross-modal reorganization in the secondary auditory cortex: DES had stronger activation and stronger connectivity between this and several other regions. We conclude that load and stimulus resolution have different neural underpinnings in the visual–verbal domain, which has consequences for current working memory models, and that for DES the secondary auditory cortex is involved in the binding of representations when task demands are low.
Decomposition and sequential-AND analysis of known cyber-attacks on critical infrastructure control systems
Authors: Maynard Peter , McLaughlin Kieran , Sezer Sakir 
Published: December 2020

Abstract
We perform a detailed survey and analysis of the most significant attacks, which have targeted industrial control systems over the past decade, based on detailed incident reports from scientific and non-traditional resources. This work is the first that considers together a comprehensive set of real-world cyber-attacks with the purpose of deriving a set of common features focusing particularly on the process control network. Each attack is decomposed to provide a comprehensive overview followed by a discussion of the commonalities identified across attacks. To achieve this, each attack is modelled using Attack Trees with Sequential AND, and mapped to the industrial control system Cyber Kill Chain. We focus on the methods of intrusion rather than the identification of actors. This article can be read in two parts: first, an analysis of each attack, and secondly a discussion of the derived commonalities. The resulting commonalities can be used to develop improved detection strategies to detect modern adversarial techniques and tactics.
Ecological and evolutionary constraints on regional avifauna of passerines in China
Authors: Cai Tianlong , Quan Qing , Song Gang , Wu Yongjie , Wen Zhixin , Zhang Chunlan , Qu Yanhua , Qiao Gexia , Lei Fumin 
Published: December 2020

Abstract
Strong correlations between species diversity and climate have been widely observed, but the mechanism underlying this relationship is unclear. Here, we explored the causes of the richness–climate relationships among passerine birds in China by integrating tropical conservatism and diversification rate hypotheses using path models. We found that assemblages with higher species richness southwest of the Salween–Mekong–Pearl River Divide are phylogenetically overdispersed and have shorter mean root distances (MRDs), while species-rich regions northeast of this divide (e.g., north Hengduan Mountains–south Qinling Mountains) are phylogenetically clustered and have longer MRDs. The results of the path analyses showed that the direct effect of climatic factors on species richness was stronger than their indirect effects on species richness via phylogenetic relatedness, indicating that neither tropical conservatism nor diversification rate hypotheses can well explain the richness–climate relationship among passerines in China. However, when path analyses were conducted within subregions separately, we found that the tropical conservatism hypothesis was well supported in the southwestern Salween–Mekong–Pearl River Divide, while the diversification rate hypothesis could explain the richness–climate relationship well in the northeastern divide. We conclude that the diversity patterns of passerines in different subregions of the Eastern Himalayas-Mountains of Southwest China may be shaped by different evolutionary processes related to geological and climatic histories, which explains why the tropical conservatism or diversification rate hypothesis alone cannot fully explain the richness–climate relationships.
HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations
Authors: Khomtchouk Bohdan B , Nelson Christopher S , Vand Kasra A , Palmisano Salvator , Grossman Robert L 
Published: December 2020

AbstractCardiovascular disease (CVD) is the leading cause of death worldwide for all genders and across most racial and ethnic groups. However, different races and ethnicities exhibit different rates of CVD and its related cardiorenal and metabolic comorbidities, suggesting differences in genetic predisposition and risk of onset, as well as socioeconomic and lifestyle factors (diet, exercise, etc.) that act upon an individual’s unique underlying genetic background. Here, we present HeartBioPortal2.0, a major update to HeartBioPortal, the world’s largest CVD genetics data precision medicine platform for harmonized CVD-relevant genetic variants, which now enables search and analysis of human genetic information related to heart disease across ethnically diverse populations and cardiovascular/renal/metabolic quantitative traits pertinent to CVD pathophysiology. HeartBioPortal2.0 is structured as a cloud-based computing platform and knowledge portal that consolidates a multitude of CVD-relevant genomic data modalities into a single powerful query and browsing interface between data and user via a user-friendly web application publicly available to the scientific research community. Since its initial release, HeartBioPortal2.0 has added new cardiovascular/renal/metabolic disease–relevant gene expression data as well as genetic association data from numerous large-scale genome-wide association study consortiums such as CARDIoGRAMplusC4D, TOPMed, FinnGen, AFGen, MESA, MEGASTROKE, UK Biobank, CHARGE, Biobank Japan and MyCode, among other studies. In addition, HeartBioPortal2.0 now includes support for quantitative traits and ethnically diverse populations, allowing users to investigate the shared genetic architecture of any gene or its variants across the continuous cardiometabolic spectrum from health (e.g. blood pressure traits) to disease (e.g. hypertension), facilitating the understanding of CVD trait genetics that inform health-to-disease transitions and endophenotypes. Custom visualizations in the new and improved user interface, including performance enhancements and new security features such as user authentication, collectively re-imagine HeartBioPortal’s user experience and provide a data commons that co-locates data, storage and computing infrastructure in the context of studying the genetic basis behind the leading cause of global mortality.Database URL: https://www.heartbioportal.com/
A pebble clogging a river: a case report of thrombosed coronary aneurysmal ectasia
Authors: Jaglan Akshar , Ajam Tarek , Port Steven C , Bajwa Tanvir , Tajik A Jamil 
Published: December 2020

Abstract

Background
Coronary artery ectasia (CAE) is a rare anomaly that can present at any age. Predisposing risk factors include Kawasaki disease in a younger population and atherosclerosis in the older generation. We present a unique case of the management of a young woman diagnosed with multivessel CAE with aneurysmal changes in the setting of acute coronary syndrome and subsequently during pregnancy.

Case summary
A 23-year-old woman presented with acute onset chest pain. Electrocardiogram revealed no ischaemic changes; however, troponin I peaked at 16 ng/mL (reference range 0–0.04 ng/mL). Echocardiogram showed apical dyskinesis with preserved left ventricular ejection fraction. Coronary angiography showed multivessel CAE along with significant thrombus burden in an ectatic lesion of the left anterior descending artery. Since the patient was haemodynamically stable, conservative management with dual antiplatelet therapy and anticoagulation was started. On follow-up, coronary computed tomographic angiogram illustrated resolution of the coronary thrombi and echocardiogram showed improvement to the apical dyskinesis. It was presumed that Kawasaki disease was the most likely aetiology of her disease. Subsequently the patient reported that, contrary to medical advice, she was pregnant, adding another layer of complexity to her case.

Discussion
Coronary artery ectasia can be discovered as an incidental finding or can present with an acute coronary syndrome. Management is challenging in the absence of randomized trials and large-scale data. Treatment options include medications, percutaneous intervention, and surgical revascularization. Close surveillance is required in these patients to assess progression of disease. Here we discuss treatment options during acute coronary syndrome and pregnancy.
A rare case of anaerobic streptococci endocarditis in a young female with bicuspid aortic valve: case report
Authors: Toader Despina , Cocora Mioara , Bătăiosu Constantin , Ocroteală Luminiă 
Published: December 2020

Abstract

Background
Bicuspid aortic valve is the most common congenital cardiovascular malformation and occurs in 1–2% of the population. The haemodynamic changes appear early, leading to tissue damage and predisposing to germs attachment. The development of perivalvular extension is a constant in bicuspid aortic valve endocarditis. Infective endocarditis with anaerobic bacteria is a rare condition with a high rate of mortality.

Case summary
We report a case of a young female with bicuspid aortic valve infective endocarditis. Involved bacteria were anaerobic streptococci, and the clinical course of the diseases was very aggressive. The echocardiographic evaluation revealed aortic and mitral regurgitation, perivalvular abscess, ventricular septum defect, and pericardial effusion. The surgery approach consisted of the aortic valve replacement with a mechanical prosthesis after radical resection of aortic root abscess and reconstruction of the annulus. The ventricular septum defect was also closed with a pericardial patch. Anticoagulation started the first day after surgery. The patient was received antibiotic therapy for 10 days before and 4 weeks after surgical intervention. Evolution was very good at 1 and 6 months follow-up.

Discussion
This is a severe case of endocarditis, complicated with extensive valvular destruction, aortic root abscess, and fistula. Perivalvular complications are frequent in patients with bicuspid aortic valve endocarditis. The ‘take away’ message is that echocardiography is an essential tool for diagnosis, management, and follow-up of patients with infective endocarditis.