bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic iliac crest bone grafting in recurrent anterior shoulder instability: minimum 5-year clinical and radiologic follow-up
Authors: Boehm Elisabeth , Minkus Marvin , Moroder Philipp , Scheibel Markus 
Published: April 2020

Abstract
Purpose
To investigate the clinical and radiologic mid- to long-term results of arthroscopic iliac crest bone-grafting for anatomic glenoid reconstruction in patients with recurrent anterior shoulder instability.

Methods
Seventeen patients were evaluated after a minimum follow-up of 5 years. Clinical [range of motion, subscapularis tests, apprehension sign, Subjective Shoulder Value (SSV), Constant Score (CS), Rowe Score (RS), Walch Duplay Score (WD), Western Ontario Shoulder Instability Index (WOSI)], and radiologic [X-ray (true a.p., Bernageau and axillary views) and computed tomography (CT)] outcome parameters were assessed.

Results
Fourteen patients [mean age 31.1 (range 18–50) years] were available after a follow-up period of 78.7 (range 60–110) months. The SSV averaged 87 (range 65–100) %, CS 94 (range 83–100) points, RS 89 (range 30–100) points, WD 87 (range 25–100) points, and WOSI 70 (range 47–87) %. The apprehension sign was positive in two patients (14%). One patient required an arthroscopic capsular plication due to a persisting feeling of instability, while the second patient experienced recurrent dislocations after a trauma, but refused revision surgery. CT imaging showed a significant increase of the glenoid index from preoperative 0.8 ± 0.04 (range 0.7–0.8) to 1.0 ± 0.11 (range 0.8–1.2) at the final follow-up (p < 0.01).

Conclusion
Arthroscopic reconstruction of anteroinferior glenoid defects using an autologous iliac crest bone-grafting technique yields satisfying clinical and radiologic results after a mid- to long-term follow-up period. Postoperative re-dislocation was experienced in one (7.1%) of the patients due to a trauma and an anatomic reconstruction of the pear-shaped glenoid configuration was observed.

Level of evidence
IV.
Completing perfect complexes
Authors: Krause Henning 
Published: April 2020

AbstractThis note proposes a new method to complete a triangulated category, which is based on the notion of a Cauchy sequence. We apply this to categories of perfect complexes. It is shown that the bounded derived category of finitely presented modules over a right coherent ring is the completion of the category of perfect complexes. The result extends to non-affine noetherian schemes and gives rise to a direct construction of the singularity category. The parallel theory of completion for abelian categories is compatible with the completion of derived categories. There are three appendices. The first one by Tobias Barthel discusses the completion of perfect complexes for ring spectra. The second one by Tobias Barthel and Henning Krause refines for a separated noetherian scheme the description of the bounded derived category of coherent sheaves as a completion. The final appendix by Bernhard Keller introduces the concept of a morphic enhancement for triangulated categories and provides a foundation for completing a triangulated category.
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice
Authors: Marino Silvia , Carrasco Giovana , Li Boya , Shah Karan M. , Lath Darren L. , Sophocleous Antonia , Lawson Michelle A. , Idris Aymen I. 
Published: April 2020

AbstractMultiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation. Pharmacological manipulation of monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (2-AG), reduced skeletal tumour burden and osteolysis associated with osteosarcoma and advanced breast and prostate cancers. MM and hematopoietic, immune and bone marrow cells express high levels of type 2 cannabinoid receptor and osteoblasts secrete 2-AG. However, the effects of MAGL manipulation on MM have not been investigated. Here, we report that treatment of pre-osteoclasts with non-cytotoxic concentrations of JZL184, a verified MAGL inhibitor, enhanced MM- and RANKL-induced osteoclast formation and size in vitro. Exposure of osteoblasts to JZL184 in the presence of MM cell-derived factors reduced osteoblast growth but had no effect on the ability of these cells to mature or form bone nodules. In vivo, administration of JZL184 induced a modest, yet significant, bone loss at both trabecular and cortical compartments of long bones of immunocompetent mice inoculated with the syngeneic 5TGM1-GFP MM cells. Notably, JZL184 failed to inhibit the in vitro growth of a panel of mouse and human MM cell lines, or reduce tumour burden in mice. Thus, MAGL inhibitors such as JZL184 can exacerbate MM-induced bone loss.
Tissue-specific epigenetic inheritance after paternal heat exposure in male wild guinea pigs
Authors: Weyrich Alexandra , Yasar Selma , Lenz Dorina , Fickel Jörns 
Published: April 2020

AbstractExternal temperature change has been shown to modify epigenetic patterns, such as DNA methylation, which regulates gene expression. DNA methylation is heritable, and as such provides a mechanism to convey environmental information to subsequent generations. Studies on epigenetic response to temperature increase are still scarce in wild mammals, even more so studies that compare tissue-specific epigenetic responses. Here, we aim to address differential epigenetic responses on a gene and gene pathway level in two organs, liver and testis. We chose these organs, because the liver is the main metabolic and thermoregulation organ, and epigenetic modifications in testis are potentially transmitted to the F2 generation. We focused on the transmission of DNA methylation changes to naive male offspring after paternal exposure to an ambient temperature increase of 10 °C, and investigated differential methylated regions of sons sired before and after the paternal exposure using Reduced Representation Bisulfite Sequencing. We detected both a highly tissue-specific epigenetic response, reflected in genes involved in organ-specific metabolic pathways, and a more general regulation of single genes epigenetically modified in both organs. We conclude that genomes are context-specifically differentially epigenetically regulated in response to temperature increase. These findings emphasize the epigenetic relevance in cell differentiation, which is essential for the specific function(s) of complex organs, and is represented in a diverse molecular regulation of genes and gene pathways. The results also emphasize the paternal contribution to adaptive processes.
Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies
Authors: Imamura Akira , Morimoto Yoshiro , Ono Shinji , Kurotaki Naohiro , Kanegae Shinji , Yamamoto Naoki , Kinoshita Hirohisa , Tsujita Takahiro , Okazaki Yuji , Ozawa Hiroki 
Published: April 2020

AbstractTwin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. The basis for these studies is that MZs share 100% of their genetic information. Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. Although recent advances in next-generation sequencing have increased the accuracy of this line of research, there has been greater emphasis placed on epigenetic changes versus DNA sequence changes as the probable cause of discordant psychiatric disorders in MZs. Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. Although it was originally thought that epigenetic changes occurred as a result of environmental factors, and thus were not transmittable, it is now known that such changes might possibly be transmitted between generations. Therefore, the potential possible effects of intestinal flora inside the body are currently being investigated as a cause of discordance in MZs. As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions.
Noise-Induced Changes of the Auditory Brainstem Response to Speech—a Measure of Neural Desynchronisation?
Authors: de Boer Jessica , Nuttall Helen E. , Krumbholz Katrin 
Published: April 2020

AbstractIt is commonly assumed that difficulty in listening to speech in noise is at least partly due to deficits in neural temporal processing. Given that noise reduces the temporal fidelity of the auditory brainstem response (ABR) to speech, it has been suggested that the speech ABR may serve as an index of such neural deficits. However, the temporal fidelity of ABRs, to both speech and non-speech sounds, is also known to be influenced by the cochlear origin of the response, as responses from higher-frequency cochlear regions are faster and more synchronous than responses from lower-frequency regions. Thus, if noise caused a reweighting of response contributions from higher- to lower-frequency cochlear regions, the temporal fidelity of the aggregate response should be reduced even in the absence of any changes in neural processing. This ‘place mechanism’ has been demonstrated for non-speech ABRs. The aim of this study was to test whether it also applies to speech ABRs. We used the so-called ‘derived-band’ method to isolate response contributions from frequency-limited cochlear regions. Broadband and derived-band speech ABRs were measured both in quiet and in noise. Whilst the noise caused significant changes to the temporal properties of the broadband response, its effects on the derived-band responses were mostly restricted to the response amplitudes. Importantly, the amplitudes of the higher-frequency derived-band responses were much more strongly affected than those of the lower-frequency responses, suggesting that the noise indeed caused a reweighting effect. Our results indicate that, as for non-speech ABRs, the cochlear place mechanism can represent a potentially substantial confound to speech-ABR-in-noise measurements.
Towards the conservation of Borneo’s freshwater mussels: rediscovery of the endemic Ctenodesma borneensis and first record of the non-native Sinanodonta lauta
Authors: Zieritz Alexandra , Taha Hussein , Lopes-Lima Manuel , Pfeiffer John , Sing Kong Wah , Sulaiman Zohrah , McGowan Suzanne , A.Rahim Khairul Adha 
Published: April 2020

AbstractThe freshwater mussel fauna of Borneo is highly endemic, with at least 11 species being unique to that island. Most of these species have not been recorded for at least 50 years owing to a lack of sampling effort and large-scale habitat destruction and degradation. Surveys conducted in 2016 across much of Malaysian Borneo failed to locate four out of five native species historically recorded in the study area. The present study aimed to determine the diversity and distribution of freshwater mussels of Brunei and adjacent Limbang Division, Malaysia. In 2018, we conducted interviews with locals, recorded environmental data and surveyed mussels at 43 sites, and conducted interviews at a further 38 sites. Only one population of native mussels, i.e. Ctenodesma borneensis, was found in a small tributary of the Limbang River situated in a patch of intact rainforest, representing the first record of this Bornean endemic genus since 1962. In addition, Sinanodonta lauta was found in a pond in Lawas district, representing the first record of this species outside its native East Asian distribution. Our data suggest that C. borneensis can sustain populations in relatively undisturbed habitats and is likely to have suffered population losses across northern Borneo. The first molecular phylogenetic analysis (COI + 28S) including an endemic Bornean freshwater mussel genus revealed that Ctenodesma is phylogenetically divergent from all other previously sampled lineages, rendering it a particularly valuable conservation target.
Belief updating: does the ‘good-news, bad-news’ asymmetry extend to purely financial domains?
Authors: Barron Kai 
Published: April 2020

AbstractBayes’ statistical rule remains the status quo for modeling belief updating in both normative and descriptive models of behavior under uncertainty. Some recent research has questioned the use of Bayes’ rule in descriptive models of behavior, presenting evidence that people overweight ‘good news’ relative to ‘bad news’ when updating ego-relevant beliefs. In this paper, we present experimental evidence testing whether this ‘good-news, bad-news’ effect is present in a financial decision making context (i.e. a domain that is important for understanding much economic decision making). We find no evidence of asymmetric updating in this domain. In contrast, in our experiment, belief updating is close to the Bayesian benchmark on average. However, we show that this average behavior masks substantial heterogeneity in individual updating behavior. We find no evidence in support of a sizeable subgroup of asymmetric updators.
Reducing radiation exposure in second-generation cryoballoon ablation without compromising clinical outcome
Authors: Holl Marijn J. , Bhagwandien Rohit E. , Firouzi Mehran , de Ruiter Wouter A. , Szili-Torok Tamas , Yap Sing-Chien 
Published: April 2020

Abstract
Purpose
Pulmonary vein isolation (PVI) using cryoballoon (CB) ablation is associated with an increased radiation exposure compared with radiofrequency ablation. Previous studies showed that radiation exposure in CB PVI can be reduced by optimizing the fluoroscopy protocol without comprising acute efficacy and safety. We evaluated the mid-term outcome of a modified fluoroscopy protocol in patients undergoing CB PVI.

Methods
The study population comprised 90 consecutive patients who underwent second-generation CB-based PVI. The first 46 patients underwent CB PVI with conventional fluoroscopy settings (group A, historic control group). In the following 44 patients (group B), a modified fluoroscopy protocol was applied consisting of (1) visualization of degree of PV occlusion only by fluoroscopy (no cine runs); (2) increased radiation awareness. Primary endpoints were the total dose area product (DAP), fluoroscopy time, and freedom from documented recurrence of atrial fibrillation (AF) after a single procedure.

Results
Group B had a lower median DAP (1393 cGycm2 vs. 3232 cGycm2, P < 0.001) and median fluoroscopy time (20 min vs. 24 min, P < 0.001) as compared with group A. The 1-year freedom from documented recurrence of AF after a single procedure was similar among groups (74% in group A vs. 77% in group B, P = 0.71). There were no significant differences between both groups for the secondary endpoints, including procedure duration, proportion of patients with complete electrical isolation, and complications.

Conclusion
Using a modified fluoroscopy protocol and increased radiation awareness, radiation exposure can be significantly reduced in CB PVI with a similar 1-year clinical outcome.
Plasma-Assisted ALD of Highly Conductive HfNx: On the Effect of Energetic Ions on Film Microstructure
Authors: Karwal Saurabh , Verheijen Marcel A. , Arts Karsten , Faraz Tahsin , Kessels Wilhelmus M. M. , Creatore Mariadriana 
Published: April 2020

AbstractIn this work, we report on the atomic layer deposition (ALD) of HfNx thin films by employing CpHf(NMe2)3 as the Hf(IV) precursor and Ar–H2 plasma in combination with external RF substrate biasing as the co-reactant. Following up on our previous results based on an H2 plasma and external RF substrate biasing, here we address the effect of ions with a larger mass and higher energy impinging on HfNx film surface during growth. We show that an increase in the average ion energy up to 304 eV leads to a very low electrical resistivity of 4.1 × 10–4 Ωcm. This resistivity value is achieved for films as thin as ~ 35 nm, and it is an order of magnitude lower than the resistivity reported in literature for HfNx films grown by either CVD or ALD, while being comparable to the resistivity of PVD-grown HfNx films. From the extensive thin film characterization, we conclude that the impinging ions during the film growth lead to the very low electrical resistivity of HfNx films by suppressing the oxygen incorporation and in-grain nano-porosity in the films.
Monitoring the Crosstalk Between the Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 with PET
Authors: Antunes I. F. , Hospers G. A. P. , Sijbesma J. W. A. , Boerema A. S. , van Waarde A. , Glaudemans A. W. J. M , Dierckx R. A. J. O. , de Vries E. G. E. , de Vries E. F. J. 
Published: April 2020

Abstract
Purpose
Ovarian cancer (OC) leads to poor survival rates mainly due to late stage detection and innate or acquired resistance to chemotherapy. Thus, efforts have been made to exploit the estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) to treat OC. However, patients eventually become resistant to these treatments as well. HER2 overexpression contributes to the acquired resistance to ER-targeted treatment. Trastuzumab treatment, on the other hand, can result in increased expression of ER, which, in turn, increases the sensitivity of the tumors towards anti-estrogen therapy. More insight into the crosstalk between ER and HER2 signaling could improve our knowledge about acquired resistance in ovarian cancer. The aim of this study was to evaluate whether PET could be used to detect changes in ER expression induced by HER2-targeted treatment in vivo.

Procedures
Male athymic nude mice were subcutaneously (sc) inoculated with 106 SKOV3 human ovarian cancer cells (HER2+/ER+). Two weeks after inoculation, tumor-bearing mice were treated intraperitoneally with either vehicle, the HER2 antibody trastuzumab (20 mg/kg, 2×/week), or the HER2-tyrosine kinase inhibitor lapatinib (40 mg/kg, 5 days/week) for 2 weeks. Thereafter, ER expression in the tumor was assessed by PET imaging with 16α-[18F]-fluoro-17β-estradiol ([18F]FES). Tumors were excised for ex vivo ER and HER2 measurement with Western blotting and immunohistochemistry.

Results
All treatments led to smaller tumors than vehicle-treated tumors. Higher [18F]FES maximum standardize tumor uptake (SUVmax) was observed in animals treated with trastuzumab (+ 29 %, P = 0.002) or lapatinib (+ 20 %, P = 0.096) than in vehicle-treated controls. PET results were in agreement with ex vivo analyses.

Conclusion
FES-PET imaging can detect changes in ER expression induced by HER2-targeted treatment and therefore can be used to investigate the crosstalk between ER and HER2 in a noninvasive manner.
Bending and vibration of a discontinuous beam with a curvic coupling under different axial forces
Authors: Liu Heng , Hong Jie , Zhang Dayi 
Published: April 2020

AbstractThe transverse stiffness and vibration characteristics of discontinuous beams can significantly differ from those of continuous beams given that an abrupt change in stiffness may occur at the interface of the former. In this study, the equations for the deflection curve and vibration frequencies of a simply supported discontinuous beam under axial loads are derived analytically on the basis of boundary, continuity, and deformation compatibility conditions by using equivalent spring models. The equation for the deflection curve is solved using undetermined coefficient methods. The normal function of the transverse vibration equation is obtained by separating variables. The differential equations for the beam that consider moments of inertia, shearing effects, and gyroscopic moments are investigated using the transfer matrix method. The deflection and vibration frequencies of the discontinuous beam are studied under different axial loads and connection spring stiffness. Results show that deflection decreases and vibration frequencies increase exponentially with increasing connection spring stiffness. Moreover, both variables remain steady when connection spring stiffness reaches a considerable value. Lastly, an experimental study is conducted to investigate the vibration characteristics of a discontinuous beam with a curvic coupling, and the results exhibit a good match with the proposed model.
The Influence of Microstructure on Corrosion Resistance of Mg-3Al-1Zn-15Li (LAZ1531) Alloy
Authors: Dobkowska Anna , Adamczyk-Cieślak Bogusława , Towarek Aleksandra , Maj Piotr , Ura-Bińczyk Ewa , Momeni Mojtaba , Kuc Dariusz , Hadasik Eugeniusz , Mizera Jarosław 
Published: April 2020

AbstractIn this study, the microstructure and corrosion resistance of the as-extruded and as-extruded with subsequent heat treatment Mg-3Al-1Zn-15Li (LAZ1531) alloys have been investigated. The alloys’ microstructures consisted ofα(Mg),β(Li), Θ-MgLi2Al and Mg17Al12. As a result of annealing, theβ(Li) toα(Mg) transformation occurred, and the recrystallization supported the reformation of the Mg17Al12. The electrochemical tests showed that the increased amount ofα(Mg) and higher amount of Mg17Al12in the heat-treated alloy favored reactions and determined it as having better corrosion resistance in 3.5 wt.% NaCl.
A Retrospective Clinical Audit of Outcomes of Cochlear Implantation in Children with Multiple Disabilities in Comparison with Normal Implantees: A South Indian Experience
Authors: Ganesh Vaishnevy , Ram Bhaskar , Nandhan Raghu , Kameswaran Mohan 
Published: April 2020

AbstractAimsCochlear implantation (CI) is established as a standard remedy for children with congenital bilateral profound hearing loss to attain hearing perception and thereby develop speech and language. A subgroup includes children with multiple disabilities in whom the implant helps to improve their quality of life and also of their families via enhanced communication skills. Cochlear implants today form an integral part of their multi-handicap rehabilitation process.Material and MethodsA retrospective cohort study was carried out on children with and without multiple handicaps who have received cochlear implantation at the cochlear implant clinic of MERF, Chennai, India over the past decade. Category of Auditory Performance (CAP) scores, Speech Intelligibility Rating (SIR) scores, and also Meaningful Auditory-Integration Scale (MAIS) and Meaningful Use of Speech Scale (MUSS) scores were compared at set time frequencies of 6 months and 12 months post-implantation between the two groups of implanted children.ResultsAll the four CAP, SIR, MAIS and MUSS scores showed improvement over time with auditory and speech therapy in both groups of children as reflected by the improvement in their quality of life. The normative group of implantees showed better improvement compared to the group of children with multiple disabilities.ConclusionIntensive habilitation is essential especially for children with multiple disabilities who have received cochlear implantation in which their special needs are addressed individually and optimised for the best outcome. The study shows that restoration of the special sense of hearing helps as a remedy to alleviate their other multi-handicaps to a notable extent.