bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metformin Ameliorates Scleroderma Via Inhibiting Th17 Cells and Reducing mTOR-STAT3 Signaling in Skin Fibroblasts
Authors: Moon Jeonghyeon , Lee Seon-yeong , Choi Jeong Won , Lee Aram , Yoo Jin Hee , Moon Su-Jin , Park Sung-Hwan , Cho Mi-La 
Published: January 2021

Abstract
Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β, IL-6, IL-17, and TNF-α play important roles in the pathogenesis of scleroderma. Because metformin, a medication used to treat diabetes, has effective immunoregulatory functions, we investigated its therapeutic function in scleroderma. Mice in a model of bleomycin-induced scleroderma were treated with metformin for 2 weeks. Histological assessment demonstrated protective effects of metformin against scleroderma. Metformin decreased the expression of pro-inflammatory factors in dermal tissue and lymphocytes. It also decreased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, IL-17, and TNF-α) and fibrosis-inducing molecules both in vivo and in vitro. These results suggest that metformin treatment has anti-inflammatory effects on lymphocytes via the inhibition of IL-17 and cytokines related to Th17 differentiation, such as IL-1β, IL-6, and TNF-α. To investigate how metformin modulates the inflammatory process in skin fibroblasts, we measured mTOR-STAT3 signaling in skin fibroblasts and found that mTOR and STAT3 protein expression were decreased by metformin treatment. These results suggest that metformin has potential to treat scleroderma by inhibiting pro-inflammatory cytokines and anti-inflammatory activity mediated by mTOR-STAT3 signaling.
ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc
Authors: Cheng Yuanyuan , Lin Lishuang , Li Xiaoyan , Lu Aiqi , Hou Chenjian , Wu Qian , Hu Xiaomu , Zhou Zhongwen , Chen ZhongQing , Tang Feng 
Published: January 2021

Abstract
Background: Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of specific and effective molecular targets. The aim of the present study is to investigate the potential roles of A Disintegrin and Metalloproteinase 10 (ADAM10) on TNBC cells and the effects of combining ADAM10 expression and neoadjuvant chemotherapy treatment (NACT) to improve the overall survival in breast cancer patients.Methods: Using a series of breast cancer cell lines, we measured the expression of ADAM10 and its substrates by quantitative real-time PCR assay (qRT-PCR) and western blot analysis. Cell migration and invasion, cell proliferation, drug sensitivity assay, cell cycle and apoptosis were conducted in MDA-MB-231 cells cultured with ADAM10 siRNA. The effect of ADAM10 down-regulation by siRNA on its substrates was assessed by western blot analysis. We performed immunohistochemical staining for ADAM10 in clinical breast cancer tissues in 94 patients receiving NACT.Results: The active form of ADAM10 was highly expressed in TNBC cell lines. Knockdown of ADAM10 in MDA-MB-231 cells led to a significant decrease in cell proliferation, migration, invasion and the IC50 value of paclitaxel and adriamycin, while induced cell cycle arrest and apoptosis. And these changes were correlated with down-regulation of Notch signaling, CD44 and cellular prion protein (PrPc). In clinical breast cancer cases, a high ADAM10 expression in pre-NACT samples was strongly associated with poorer response to NACT and shorter overall survival. Conclusions: These data suggest the previously unrecognized roles of ADAM10 in contributing to the progression and chemo-resistance of TNBC.
Comprehensively addressing postpartum maternal health: A content and image review of commercially available mobile health apps
Authors: Tucker Laura , Villagomez Alan Cuevas , Krishnamurti Tamar 
Published: January 2021

Abstract
Background: The United States is currently facing a maternal morbidity and mortality crisis, with the highest rates of any resource-rich nation. In efforts to address this, new guidelines for postpartum care suggest that mobile health apps can help provide complementary clinical support for new mothers during the postpartum period. However, to date no study has evaluated existing mobile health tools targeted to this time period for sufficiency of maternal health information, inclusivity of people of color, or accessibility to users.Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were used to review the peripartum apps from the Apple and Google Play stores in either the Health/Fitness, Medical, or Education categories. Apps were then evaluated for extent and quality of maternal health information, inclusivity of people of color, and accessibility to app users.Results: Of the 301 apps from the Apple and Google Play stores, 25 met criteria for final evaluation. Of the 30 maternal health topics coded for, the median number addressed by apps was 19.5 (65%). Peripartum behaviors were more frequently addressed than peripartum outpatient care topics and peripartum acute health risks. The amount of maternal health information correlated positively with the Mobile Application Rating Scale (MARS) quality score of the app, and inclusivity of people of color in app imagery also correlated positively with the MARS quality score. Only 8 apps (32%) portrayed greater than 24% images of people of color- the percent of non-white Americans according to 2019 census estimates. There was no correlation between number of users as estimated by number of store ratings and MARS quality. In addition, apps with clinical authority had greater MARS engagement, information, aesthetics, and quality scores, but did not have greater numbers of store ratings.Conclusions: Current commercially available peripartum apps overall do not provide adequate maternal health information, are not inclusive of women of color, and are not optimally accessible to the target users. Apps authored with clinical authority and higher-quality apps, by MARS score, are more likely to meet these standards, but are not more likely to be downloaded and used.
The Situation of Elderly With Cognitive Impairment Living at Home During Lockdown in the Corona-pandemic in Germany
Authors: Thyrian Jochen René , Kracht Friederike , Nikelski Angela , Boekholt Melanie , Schumacher-Schönert Fanny , Rädke Anika , Michalowsky Bernhard , Vollmar Horst Christian , Hoffmann Wolfgang , Rodriguez Francisca S. , Kreisel Stefan H. 
Published: January 2021

Abstract
Background: The outbreak of the Corona virus is a challenge for health care systems worldwide. The aim of this study is to analyze a) knowledge about, and feelings related to the Corona-pandemic. Describe b) loneliness, depression and anxiety and, c) the perceived, immediate impact of the lockdown on frequency of social contacts and quality of health care provision of people with cognitive impairment during social distancing and lockdown in the primary care system and living at home in Germany. Methods: This analysis is based on data of a telephone-based assessment in a convenience sample of n=141 people with known cognitive impairment in the primary care setting. Data on e.g. cognitive and psychological status prior to the pandemic was available. Attitudes, knowledge about and perceived personal impact of the pandemic, social support, loneliness, anxiety, depression, change in the frequency of social activities due to the pandemic and perceived impact of the pandemic on health care related services were assessed during the time of lockdown. Results: The vast majority of participants are sufficiently informed about Corona (85%) and most think that the measures taken are appropriate (64%). A total of 11% shows one main symptom of a depression according to DSM-V. The frequency of depressive symptoms has not increased between the time before pandemic and lockdown in almost all participants. The sample shows minimal (65.0%) or low symptoms of anxiety (25%). The prevalence of loneliness is 10%. On average seven activities have decreased in frequency due to the pandemic. Social activities related to meeting people, dancing or visiting birthdays have decreased significantly. Talking with friends by phone and activities like gardening have increased. Utilization of health care services like day clinics, relief services and prescribed therapies have been reported to have worsened due to the pandemic. Visits to general practitioners decreased. Conclusions: The study shows a small impact of the pandemic on psychological variables like depression, anxiety and loneliness in the short-term. There is a decrease in social activities as expected. The impact on health care provision is prominent. There is a need for qualitative, in-depth studies to further interpret the results.
Особенности взаимосвязей эмоционального интеллекта и личностных черт у социально активных студентов
Authors: Дикая Людмила А. , Обухова Юлия В. , Егорова Валерия А. , Егоров Илья Н. 
Published: January 2021

Introduction. This study is a first exploration of associations between emotional intelligence and personality traits in a new generation of socially active students. The authors consider associations of emotional intelligence and personality traits both on levels of domains and facets.
Methods. The study sample comprised 132 students of Southern Federal University aged 17–25 years (80 females and 52 males). All the respondents were representatives of socially active youth; they took an active part in professional and creative competitions, social projects, and self-assessed their level of social activity as high or above average. The study used the following psychological tests: (a) the EmIn inventory for assessing emotional intelligence by D. V. Lyusin and (b) the Big Five Inventory-2 modified by S. A. Schebetenko. The statistical data processing was performed using R software, employing descriptive, correlational, and regression analysis methods.
Results and Discussion. Socially active students’ emotional intelligence had general (characteristic of all its components) and specific (characteristic of its individual components) associations with personality traits. General associations are those among ‘negative emotionality’ and ‘anxiety’ and all the structural components of emotional intelligence. Positive associations among ‘energy level’ and the components of emotional intelligence related to managing emotions, and negative ones among ‘emotional volatility’ and structural components of intrapersonal emotional intelligence (p ≤ 0.05) are classified as specific. The combination of negative emotionality and agreeableness affects general and interpersonal emotional intelligence; the combination of extraversion and negative emotionality affects intrapersonal emotional intelligence.
Conclusion. The results can be applied for the development of students’ individual educational trajectories and recommendations for psychological and pedagogical support of students with leadership talent and special educational needs in social activity.
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma
Multiforme
Authors: Saad Suma , Beg Sarwar , Jain Gaurav K. , Ahmad Farhan J. 
Published: January 2021

Abstract:
Glioblastoma multiforme (GBM) is a typical category of the most common and aggressive brain tumors,
with a high incidence in older adults, particularly in males. Although the etiology of GBM has not been fully elucidated,
yet it is characterized by highly proliferative activity in the glial cells. Its complete resection is impossible, and
radiotherapy is not always efficient for complete relief. Thus, GBM remains a therapeutic challenge in neurooncology
as there is no treatment that provides significant improvement in the survival rate of patients. In this regard,
the identification of newer drug therapy for the treatment of GBM is gaining popularity. However, identifying new
targets and developing new leads for screening suitable drug candidates require the investment of resources like time,
money, and efforts. It has been observed in many research studies that the use of polyunsaturated fatty acids (PUFAs)
as therapeutic moieties for cancer treatment has yielded significant interest owing to their cost-effective availability,
limited side effects, and insensitivity towards drug resistance. Nevertheless, the implications of nanostructured therapeutic
systems in delivering the PUFAs can provide significant improvement in their biopharmaceutical performance
and antitumor activity over the existing alkylating agents used as chemotherapeutic drugs in GBM. Currently, various
studies have shown that PUFAs, especially γ-linolenic acid (GLA), have selective tumoricidal action and the
ability to reduce antioxidant contents of the glioma tumor cells. In this regard, the present review endeavors to provide
an insight into the applications of nanomedicinal drug carriers used for delivering the PUFAs for the effective
treatment of GBM and associated diseases.
Recent Advances of Biomass Derived Electrode Materials for Capacitive
Deionization
Authors: Liu Yong , Gao Xin , Zhang Lu , Du Xin , Dou Xinyue , Shen Xiaolong , Zhu Haiguang , Yuan Xun 
Published: January 2021

:
Capacitive deionization (CDI), as a novel, energy-efficient, and environment-friendly desalination technology,
has received substantial attention in the scientific community during the last five decades, while the electrode materials,
acting as the ion storage media, play a vital role during its desalination process. Meanwhile, developing electrode
materials from biomass has been proven to be a feasible strategy due to their abundance in nature, unique microstructure,
as well as feasibility for further modifications. In this review, various bio-mass-based electrode materials and their unique
advantages as CDI electrodes are systematically presented.
Biomimetic Copper Oxide Nanoparticles and its Validation Through
In-silico Approach on Cardiac Enzymes
Authors: P Jacquline Rosy , Shanmugam VenkatKumar , Jas Jebastin Sonia , Jayakodi Santhoshkumar 
Published: January 2021

Background:
The present study outlines the green synthesis of copper oxide (GS-CuO) nanoparticles using
Magnolia champaca plant floral extract for the first time. Computational analysis showed the role of GS-CuO
nanoparticles on cardiac enzymes ACE2 and SOD1 functional expression through hydrogen bond interaction with amino
acid residues.

Method:
The synthesized GS-CuO nanoparticles were characterized by various techniques like X-Ray Diffraction, UVVis Spectrophotometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Transmission
Electron Microscopy.

Results:
Nanoparticles demonstrate the presence of spherical shape and size 20 nm. The particles have many active sites
and as compared to the bulk materials, and thus, the computational analysis was conducted against angiotensin-converting
enzyme and superoxide dismutase to visualize the cardioprotective effects.

Conclusion:
The in-silico approach established valuable information on cardioprotective effects of green synthesized
oxide nanoparticles using Magnolia champaca.
Boundary Conditions Analysis of Circular Capacitive Micromachined Ultrasonic Transducer (CMUT) Devices
Authors: Wang Jiujiang , Yu Yuanyu , Kuang Jiangming , Zhang Shuang , Xu Jing , Liu Xin 
Published: January 2021

Background:
Capacitive Micromachined Ultrasonic Transducer (CMUT) is a new type
of ultrasound transducer that has gained much research interest in ultrasound imaging because of its
wider bandwidth, higher receiving sensitivity, and is more likely to be integrated with an integrated
circuit (IC). The analytical solution is intuitive, fast, and convergent among simulation methods.
The membrane deflection is important to the CMUT performance. The deformation of a circular
CMUT under an external force can be described by von Kármán equations.

Objective:
To find suitable boundary conditions that are crucial for the governing equations to be
properly solved to get the analytical solutions for membrane deformation.

Methods:
Features of two commonly used CMUT fabrication methods, Sacrificial Release method
(SR) and Wafer Bonding (WB) method, are introduced. The force and moment equilibrium conditions
of the supporting post are analyzed to get the boundary condition equations.

Results:
The analytical results match well with the Finite Element Method (FEM) results for the
fixed boundary condition while there are still some differences for the elastic boundary condition.

Conclusion:
The boundary conditions for SR fabricated devices are elastic support while the
boundary conditions for WB fabricated devices are fixed.
Моделирование оптимальной оптической системы ввода/вывода излучения для реализации эффективного зондового усиления электромагнитного поля для случая непрозрачных образцов
Authors: Трусов М.А. , Ефимов А.Е. , Соловьева Д.О. , Васкан И.С. , Олейников В.А. , Мочалов К.Е. 
Published: January 2021

Competitive schemes for constructing an optical system for combining a scanning probe microscope and optical microspectrometer, allowing the study of opaque samples by the method of tip enhancement of the Raman scattering intensity, are considered. Optimal objectives for the implementation of each scheme, taking into account the presence of a scanning microscope probe, are selected. The efficiency of usage of each optical scheme is estimated quantitatively for both excitation of a Raman scattering signal and collecting secondary radiation. As a result, the most effective optical system in terms of "excitation / collection“ parameter is revealed.
Access to Technology and Preferences for an mHealth Intervention to Promote Medication Adherence in Pediatric Acute Lymphoblastic Leukemia: Approach Leveraging Behavior Change Techniques
Authors: Heneghan Mallorie B , Hussain Tasmeen , Barrera Leonardo , Cai Stephanie W , Haugen Maureen , Morgan Elaine , Rossoff Jenna , Weinstein Joanna , Hijiya Nobuko , Cella David , Badawy Sherif M 
Published: January 2021

Background
Suboptimal adherence to 6-mercaptopurine (6-MP) is prevalent in pediatric acute lymphoblastic leukemia (ALL) and associated with increased risk of relapse. Rapid uptake of personal technology makes mobile health (mHealth) an attractive platform to promote adherence.

Objective
Study objectives were to examine access to mobile technology and preferences for an mHealth intervention to improve medication adherence in pediatric ALL.

Methods
A cross-sectional survey was administered in oncology clinic to parents of children with ALL as well as adolescents and young adults (AYAs) with ALL receiving maintenance chemotherapy.

Results
A total of 49 parents (median age [IQR] 39 [33-42] years; female 76% [37/49]) and 15 patients (median age [IQR] 17 [16-19]; male 80% [12/15]) participated. All parents and AYAs owned electronic tablets, smartphones, or both. Parents’ most endorsed mHealth app features included a list of medications (71%, 35/49), information about 6-MP (71%, 35/49), refill reminders (71%, 35/49), and reminders to take 6-MP (71%, 35/49). AYAs' most endorsed features included refill reminders (73%, 11/15), reminders to take 6-MP (73%, 11/15), and tracking 6-MP (73%, 11/15).

Conclusions
Parents and AYAs reported ubiquitous access to mobile technology and strong interest in multiple adherence-specific mHealth app features. Parents and AYAs provided valuable insight into preferred features for a multifunctional behavioral intervention (mHealth app) to promote medication adherence in pediatric ALL.
SCIENCE AND TECHNOLOGY FOR SMAN 7 AND SMAN 8 PADANG IN LEARNING SKILLS USING LEARNING MEDIA CHARACTER BASED
Authors: Mana Lira Hayu Afdetis 
Published: January 2021

Nilai bahasa Indonesia siswa di SMAN 7 dan SMAN 8 Padang masih banyak berada di bawah KKM. Salah satu penyebabnya adalah kurangnya minat siswa dalam pembelajaran menyimak dan masih banyak guru yang belum menggunakan media dalam proses pembelajaran. Untuk mengatasi masalah tersebut diadakan IbM (Iptek bagi Masyarakat) dengan menggunakan media pembelajaran berbasis karakter. Tujuan pelaksanaan IbM ini adalah: (a) memberikan media pembelajaran berbasis karakter yang dapat digunakan dalam pembelajaran menyimak pada mata pelajaran bahasa Indonesia, (b) meningkatkan pemahaman tentang konsep pembelajaran menyimak dalam kurikulum 2013, (c) memberikan pelatihan terhadap guru untuk ikut membuat dan mengaplikasikan media pembelajaran berbasis karakter. Metode yang digunakan pada kegiatan Iptek bagi Masyarakat ini adalah pelatihan atau pembimbingan terhadap guru SMAN 7 dan SMAN 8 Padang untuk dapat menggunakan media pembelajaran menyimak berbasis karakter. Media pembelajaran berbasis karakter tersebut tersedia dalam bentuk audiovisual yang bisa didapatkan dari internet namun terdapat nilai pendidikan karakter di dalamnya. Media tersebut ditranskripkan dalam modul pembelajaran. Kegiatan ini dilaksanakan selama delapan kali pertemuan pada masing-masing sekolah dan melibatkan empat orang guru bahasa Indonesia dari masing-masing sekolah tersebut. Hasil pelaksanaan kegiatan ini adalah guru bahasa Indonesia di SMAN 7 dan SMA 8 Padang dapat menggunakan media pembelajaran berbasis karakter dalam pembelajaran menyimak.
New Chapters in the History of St. Petersburg School of Psychology
Authors: Loginova Natal'ya 
Published: January 2021

The history of St. Petersburg school of psychology has not been sufficiently studied if compared to foreign and Moscow scientific schools. The article provides new specific information on the institutionalization of psychology in Leningrad in the postwar period due to the establishment of the department and division, and later on, in 1966, the Faculty of Psychology at Leningrad (now St. Petersburg) State University. The author specifies the facts regarding the influence of historical cataclysms, postwar political events, ideological campaigns on the deve­lopment of psychological science and education: The Great Patriotic war, “the struggle against cosmopolitanism”, Joint Session of the USSR Academy of Sciences and the Academy of Medical Sciences focused on the teachings of I.P. Pavlov, changes in the country’s situation and sciences during the “Soviet thaw”, etc. The consequences of these events resulted in the abrupt suspension of communications with foreign colleagues in 1948. The reestablishment and expansion of international contacts occurred in the second half of the 1950s.
The information concerning the scientific school staff and B.G. Ananyev’s remarkable contribution to the school focused establishment in the course of his hard daily work as Head of Psychology Department at the university, Dean of the Faculty of Psychology, and Director of the Research Institute of Pedagogy has been supplemented. The facts about B.G. Ananyev’s initiatives to create the Institute of Comprehensive Social Studies within Leningrad University, the laboratory of differential psychology and anthropology, and to organize comprehensive studies of human individuality have been documented. The author establishes the date when Ananyev began vigo­rously writing his book “Man as a Subject of Cognition” (1963).
The development of St. Petersburg school of psychology was uneven, often against the odds. The collective work style at school was democratic and creative. The school educated professional psychologists; the best of them became prominent figures in the national science. The article presents a new periodization of St. Petersburg school of psychology, which identifies the Bekhterev, post-Bekhterev, Ananyev and post-Ananyev development periods.