bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-TEVAR in treatment of stent graft-induced new entry between two non-overlapping stent-grafts: a case report
Authors: He Yiwei , Tang Shoujun , Zhang Yongheng , Liu Jianping , Zhou Haining 
Published: October 2020

Abstract
Background
Progress of the aortic disease after the stent graft treatment of aortic dissection implicates the potential risks of stent graft-induced new entry (SINE). Although rarely reported, it should be vigilant in patients who might incur serious complication in early period after the thoracic endovascular aortic repair (TEVAR). Thus, the development of aortic disease-specific stent grafts would assist in achieving positive patient outcomes when suffering SINE. However, it is an extremely rare for SINE between two non-overlapping stent-grafts.

Case presentation
We here reported a 59-year-old male patient with sudden onset of chest pain for 4 h. Multi-detector computed tomography (MDCT) revealed a huge SINE formed between two non-overlapping stent-grafts. The re-TEVAR surgery was performed and the patient experienced a good recovery.

Conclusion
The SINE between two non-overlapping stent-grafts treated by re-TEVAR operation was alternative and feasible. The short-term and medium-term follow-up results were satisfactory.
Prevention, recognition, and management of adverse events associated with gemtuzumab ozogamicin use in acute myeloid leukemia
Authors: Cortes Jorge E. , de Lima Marcos , Dombret Hervé , Estey Elihu H. , Giralt Sergio A. , Montesinos Pau , Röllig Christoph , Venditti Adriano , Wang Eunice S. 
Published: October 2020

AbstractGemtuzumab ozogamicin (GO), a humanized anti-CD33 monoclonal antibody conjugated to the cytotoxic antibiotic agent calicheamicin, is approved for the treatment of newly-diagnosed CD33 + AML in adults and children ≥ 1 month old, and relapsed or refractory CD33 + AML in adults and children ≥ 2 years old. GO treatment has been associated with an increased risk of hepatotoxicity and hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS), especially following hematopoietic stem cell transplantation. Other non-specific serious adverse events (SAEs) associated with GO treatment are myelosuppression, bleeding/thrombocytopenia, infusion-related reaction, and tumor lysis syndrome. This report summarizes an expert panel of physicians’ recommendations for the evaluation and management of SAEs following GO, emphasizing the prevention and management of VOD/SOS.
RETRACTED ARTICLE: SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway
Authors: Han Shuai , Zhen Wei , Guo Tongqi , Zou Jianjun , Li Fuyong 
Published: October 2020

Abstract
Background
Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which are important factors in glioblastoma progression. However, the exact details of TAMs in glioblastoma progression have yet to be determined.

Methods
The clinical relevance of SET domain bifurcated 1 (SETDB1) was analyzed by immunohistochemistry, real-time PCR and Western blotting of glioblastoma tissues. SETDB1-induced cell proliferation, migration and invasion were investigated by CCK-8 assay, colony formation assay, wound healing and Transwell assay. The relationship between SETDB1 and colony stimulating factor 1 (CSF-1), as well as TAMs recruitment was examined by Western blotting, real-time PCR and syngeneic mouse model.

Results
Our findings showed that SETDB1 upregulated in glioblastoma and relative to poor progression. Gain and loss of function approaches showed the SETDB1 overexpression promotes cell proliferation, migration and invasion in glioblastoma cells. However, knockdown SETDB1 exerted opposite effects in vitro. Moreover, SETDB1 promotes AKT/mTOR-dependent CSF-1 induction and secretion, which leads to macrophage recruitment in the tumor, resulted in tumor growth.

Conclusion
Our research clarified that SETDB1 regulates of tumor microenvironment and hence presents a potential therapeutic target for treating glioblastoma.
A commentary on podiatry during the Covid‐19 pandemic
Authors: Chadwick Paul , Ambrose Lawrence , Barrow Ross , Fox Martin 
Published: October 2020

AbstractBackgroundThe arrival of the novel coronavirus (SARS‐CoV‐2) has impacted the many aspects of modern life, especially, in the immediate term, the delivery of healthcare.ContextThis commentary examines the profession of podiatry and how it has adapted and responded to the emerging crisis. It focusses on but is not exclusive to the position in the United Kingdom (UK) and the edicts and direction from the UK Government.Podiatry roles during the pandemicIt describes the role of podiatry in the pandemic and highlights the deployment of podiatry resources to fight the pandemic beyond traditional podiatric practice. It also looks at the shift from conventional consultation to digital solutions for managing patients in an effort to achieve the goals of maintenance of foot health whilst reducing the spread of the virus. The commentary summarises the emerging data related to a possible foot related presentation of the coronavirus.ConclusionThe podiatry profession proved its flexibility and adaptability during the pandemic, to adjust rapidly to ensure that patients were able to access treatment to reduce risk of infection, ulceration and amputation. Dermatological presentations on the feet have been associated with Covid‐19 in adolescents as is often the case in viral infections. CPD webinars to support clinicians and manage and prevent the spread of Covid‐19 have been widely disseminated along with algorithms to ensure that patients that need treatment are being treated appropriately. Podiatrists have embraced remote technology to ensure that patients are correctly and safely triaged and, signposted and given appropriate self‐care advice. MSK podiatrists have the ability to play an intrinsic role within the post discharge rehabilitation pathway.
Gut-liver crosstalk in sepsis-induced liver injury
Authors: Sun Jian , Zhang Jingxiao , Wang Xiangfeng , Ji Fuxi , Ronco Claudio , Tian Jiakun , Yin Yongjie 
Published: October 2020

AbstractSepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clearance, production of acute-phase proteins (APPs) and cytokines, and metabolic adaptation to inflammation. Increased levels of inflammatory cytokines and impaired bacterial clearance and disrupted metabolic products can cause gut microbiota dysbiosis and disruption of the intestinal mucosal barrier. Changes in the gut microbiota play crucial roles in liver injury during sepsis. Bacterial translocation and resulting intestinal inflammation lead to a systemic inflammatory response and acute liver injury. The gut-liver crosstalk is a potential target for therapeutic interventions. This review analyzes the underlying mechanisms for the gut-liver crosstalk in sepsis-induced liver injury.
Clonal tracing reveals diverse patterns of response to immune checkpoint blockade
Authors: Gu Shengqing Stan , Wang Xiaoqing , Hu Xihao , Jiang Peng , Li Ziyi , Traugh Nicole , Bu Xia , Tang Qin , Wang Chenfei , Zeng Zexian , Fu Jingxin , Meyer Cliff , Zhang Yi , Cejas Paloma , Lim Klothilda , Wang Jin , Zhang Wubing , Tokheim Collin , Sahu Avinash Das , Xing Xiaofang , Kroger Benjamin , Ouyang Zhangyi , Long Henry , Freeman Gordon J. , Brown Myles , Liu X. Shirley 
Published: October 2020

AbstractBackgroundImmune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but elucidating the molecular and cellular drivers of resistance for individual tumors remains challenging. We sought to determine whether a tumor with defined genetic background exhibits a stereotypic or heterogeneous response to ICB treatment.ResultsWe establish a unique mouse system that utilizes clonal tracing and mathematical modeling to monitor the growth of each cancer clone, as well as the bulk tumor, in response to ICB. We find that tumors derived from the same clonal populations showed heterogeneous ICB response and diverse response patterns. Primary response is associated with higher immune infiltration and leads to enrichment of pre-existing ICB-resistant cancer clones. We further identify several cancer cell-intrinsic gene expression signatures associated with ICB resistance, including increased interferon response genes and glucocorticoid response genes. These findings are supported by clinical data from ICB treatment cohorts.ConclusionsOur study demonstrates diverse response patterns from the same ancestor cancer cells in response to ICB. This suggests the value of monitoring clonal constitution and tumor microenvironment over time to optimize ICB response and to design new combination therapies. Furthermore, as ICB response may enrich for cancer cell-intrinsic resistance signatures, this can affect interpretations of tumor RNA-seq data for response-signature association studies.
Demonstrating the presence of Ehrlichia canis DNA from different tissues of dogs with suspected subclinical ehrlichiosis
Authors: Rodríguez-Alarcón Carlos A. , Beristain-Ruiz Diana M. , Olivares-Muñoz Angélica , Quezada-Casasola Andrés , Pérez-Casio Federico , Álvarez-Martínez Jesús A. , Tapia-Alanís Jane , Lira-Amaya José J. , Rivera-Barreno Ramón , Cera-Hurtado Orlando S. , Ibancovichi-Camarillo José A. , Soon-Gómez Luis , Adame-Gallegos Jaime R. , Figueroa-Millán Julio V. 
Published: October 2020

AbstractBackgroundNowadays,Ehrlichia canisreceives increasing attention because of its great morbidity and mortality in animals. Dogs in the subclinical and chronic phases can be asymptomatic, and serological tests show cross-reactivity and fail to differentiate between current and past infections. Moreover, there could be low parasitaemia, andE. canismight be found only in target organs, hence causing results to be negative by polymerase chain reaction (PCR) on blood samples.MethodsWe evaluated by PCR the prevalence ofE. canisin blood, liver, spleen, lymph node and bone marrow samples of 59 recently euthanised dogs that had ticks but were clinically healthy.ResultsIn total, 52.55% of the blood PCRs forE. caniswere negative, yet 61.30% yielded positive results from tissue biopsies and were as follows: 63.15% from bone marrow; 52.63% from liver; 47.36% from spleen; and 15.78% from lymph node. In addition, 33% had infection in three tissues (spleen, liver and bone marrow).ConclusionsOur results show the prevalence ofE. canisfrom tissues of dogs that were negative by blood PCR.Ehrlichia canisDNA in tissue was 30% lower in dogs that tested negative in PCR of blood samples compared to those that were positive. However, it must be taken into account that some dogs with negative results were positive forE. canisin other tissues.
Modelling the impact of climate change on the distribution and abundance of tsetse in Northern Zimbabwe
Authors: Longbottom Joshua , Caminade Cyril , Gibson Harry S. , Weiss Daniel J. , Torr Steve , Lord Jennifer S. 
Published: October 2020

Abstract
Background
Climate change is predicted to impact the transmission dynamics of vector-borne diseases. Tsetse flies (Glossina) transmit species of Trypanosoma that cause human and animal African trypanosomiasis. A previous modelling study showed that temperature increases between 1990 and 2017 can explain the observed decline in abundance of tsetse at a single site in the Mana Pools National Park of Zimbabwe. Here, we apply a mechanistic model of tsetse population dynamics to predict how increases in temperature may have changed the distribution and relative abundance of Glossina pallidipes across northern Zimbabwe.

Methods
Local weather station temperature measurements were previously used to fit the mechanistic model to longitudinal G. pallidipes catch data. To extend the use of the model, we converted MODIS land surface temperature to air temperature, compared the converted temperatures with available weather station data to confirm they aligned, and then re-fitted the mechanistic model using G. pallidipes catch data and air temperature estimates. We projected this fitted model across northern Zimbabwe, using simulations at a 1 km × 1 km spatial resolution, between 2000 to 2016.

Results
We produced estimates of relative changes in G. pallidipes mortality, larviposition, emergence rates and abundance, for northern Zimbabwe. Our model predicts decreasing tsetse populations within low elevation areas in response to increasing temperature trends during 2000–2016. Conversely, we show that high elevation areas (> 1000 m above sea level), previously considered too cold to sustain tsetse, may now be climatically suitable.

Conclusions
To our knowledge, the results of this research represent the first regional-scale assessment of temperature related tsetse population dynamics, and the first high spatial-resolution estimates of this metric for northern Zimbabwe. Our results suggest that tsetse abundance may have declined across much of the Zambezi Valley in response to changing climatic conditions during the study period. Future research including empirical studies is planned to improve model accuracy and validate predictions for other field sites in Zimbabwe.
Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods
Authors: Epopa Patric Stephane , Millogo Abdoul Azize , Collins Catherine Matilda , North Ace R. , Benedict Mark Quentin , Tripet Frederic , OʼLoughlin Samantha , Dabiré Roch K. , Ouédraogo Georges Anicet , Diabaté Abdoulaye 
Published: October 2020

Abstract
Background
One of the promising current approaches to curb malaria lies in genetic vector control, the implementation of which will require an improved understanding of the movement of genetic constructs among mosquito populations. To predict potential gene flow from one area to another, it is important to begin to understand mosquito dynamics outside of the commonly-sampled village areas, and thus how genes may move between villages. This study assessed the presence and relative abundance of mosquitoes in a 6-km corridor between two villages in western Burkina Faso.

Methods
The area surrounding the villages was mapped and the road between them was used as the basis of a transect along which to sample. Five collection points were placed along this transect. To investigate both larval and adult mosquito presence, multiple sampling approaches were used surrounding each point: searching for larval sites in an area of 500 m radius, swarm sampling, human landing catches (HLC), CDC light traps and backpack aspiration catches of potential resting sites. Sampling took place twice: in September and October 2015.

Results
Adult mosquitoes from six species of Anopheles and three other genera were found along the whole transect. Anopheles gambiae (s.l.) was the most abundant followed by Anopheles nili and Anopheles coustani. Larvae of Anopheles spp. were found in small pools of surface water along the whole transect, though their presence increased with human proximity. HLC and aspiration were the most efficient methods of collecting adult mosquitoes along the whole transect, indicating that there are both host-seeking and resting mosquitoes well away from core village areas. In contrast, swarms of male mosquitoes, thought to be the principle mating locations of Anopheles spp. mosquitoes in West Africa, were only found close to the core village areas.

Conclusions
This preliminary study indicates that Anopheles spp. mosquitoes are both present and breeding in low human-density areas along transit axes and provides both a relative evaluation of methods for use in these areas and evidence that gene flow between Sahelian population centres is likely. More robust and structured studies are nevertheless needed to come with stronger conclusions.
Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
Authors: Yip Ashley , Jernberg Elizabeth Torrey , Bardi Mohammad , Geiger Julia , Lohne Frode , Schmidt Wolfgang Andreas , Myklebust Geirmund , Diamantopoulos Andreas P. 
Published: October 2020

Abstract
Background
There has been a shift in recent years to using ultrasound (US) and magnetic resonance imaging (MRI) as first-line investigations for suspected cranial large vessel vasculitis (LVV) and is a new recommendation by the EULAR 2018 guidelines for imaging in LVV. This cross-sectional study compares the performance of US and MRI and contrast-enhanced magnetic resonance angiography (MRA) for detecting vasculitis in patients with giant cell arteritis (GCA).

Methods
Patients with new-onset or already diagnosed GCA were recruited. The common temporal arteries and supra-aortic large vessels were evaluated by US and MRI/MRA. Blinded experts read the images and applied a dichotomous score (vasculitis: yes/no) in each vessel.

Results
Thirty-seven patients with giant cell arteritis (GCA) were recruited. Two patients were excluded. Of the remaining patients, nine had new-onset disease and 26 had established disease. Mean age was 71 years, and median C-reactive protein (CRP) was 7.5 mg/L. The median time between US and MRI was 1 day. Overall, US revealed vasculitic changes more frequently than MRI (p < 0.001). US detected vascular changes in 37% of vessels compared to 21% with MRI. Among patients with chronic disease, US detected vascular changes in 23% of vessels compared to 7% with MRI in (p < 0.001). The same was true for patients with new-onset disease. US detected vasculitic changes in 22% of vessels and MRI detected disease in 6% (p = 0.0004). Compared to contrast-enhanced MRA, US was more sensitive in detecting vasculitic changes in the large arteries, including the axillary, carotid, and subclavian arteries.

Conclusion
US more frequently detects vasculitic changes in the large arteries compared to contrast-enhanced MRA. When evaluating the cranial vessels, US performs similarly to MRI. This data supports the recommendation that US be considered as a first-line evaluation in patients suspected to have GCA.
Using vision-based object detection for link quality prediction in 5.6-GHz channel
Authors: Kudo Riichi , Takahashi Kahoko , Inoue Takeru , Mizuno Kohei 
Published: October 2020

AbstractVarious smart connected devices are emerging like automated driving cars, autonomous robots, and remote-controlled construction vehicles. These devices have vision systems to conduct their operations without collision. Machine vision technology is becoming more accessible to perceive self-position and/or the surrounding environment thanks to the great advances in deep learning technologies. The accurate perception information of these smart connected devices makes it possible to predict wireless link quality (LQ). This paper proposes an LQ prediction scheme that applies machine learning to HD camera output to forecast the influence of surrounding mobile objects on LQ. The proposed scheme utilizes object detection based on deep learning and learns the relationship between the detected object position information and the LQ. Outdoor experiments show that LQ prediction proposal can well predict the throughput for around 1 s into the future in a 5.6-GHz wireless LAN channel.
Global existence of classical solutions to the two-dimensional compressible Boussinesq equations in a square domain
Authors: Huang Xucheng , Shang Zhaoyang , Zhang Na 
Published: October 2020

AbstractIn this paper, we consider the initial boundary value problem of two-dimensional isentropic compressible Boussinesq equations with constant viscosity and thermal diffusivity in a square domain. Based on the time-independent lower-order and time-dependent higher-order a priori estimates, we prove that the classical solution exists globally in time provided the initial mass$\|\rho _{0}\|_{L^{1}}$∥ρ0∥L1of the fluid is small. Here, we have no small requirements for the initial velocity and temperature.
Stakeholder perceptions about sustainability governance in the German biogas sector
Authors: Horschig Thomas , Schaubach Kay , Sutor Catharina , Thrän Daniela 
Published: October 2020

AbstractBackgroundSince the steady growth of the German biogas sector, its sustainability is subject to constant scrutiny, especially economic and environmental sustainability. Public concerns about sustainability of biogas started with the issue of energy crop cultivation in the 2010s. To steer sustainability in the biogas sector, a broad variety of regulations and acts were enacted, mainly via top-down legislation making. But in order to govern sustainability in every step of the value chain, involvement of numerous stakeholders in the biogas sector is necessary. This paper will address the question: What are the perceptions of the relevant stakeholders in the biogas sector regarding various sustainability issues and what are their expectations?MethodsFollowing an instrumental approach, three steps were initially undertaken for the systematic analysis of the stakeholder landscape, namely (1) stakeholder identification, (2) stakeholder categorization, and (3) investigation of stakeholder relationships. In addition, a theoretical mapping was performed to identify those actors, who most likely impact the implementation of biogas value chains, or are strongly affected by this implementation. These were then subject to surveys via questionnaires and semi-structured interviews to gather information on their sustainability governance perception.ResultsResults indicate that key players are farmers and biogas associations due to anchoring in agricultural sector, along with environmental non-governmental organizations (NGOs) and policy makers. Furthermore, the surveyed stakeholders agree on regulating sustainability at national level, while tending toward neutral or even disagreeing for the regulation of sustainability at local and international level. They also agree that certification and standards can be an effective tool for compliant sustainability governance.ConclusionsThis study revealed a clear expectation gap regarding the transfer of the current energy legislation in a bio-economy and how sustainability shall be steered then (mandatory/voluntary and local (national) level/international level). The surveyed stakeholders expect transparent and clear rules from the government to steer sustainability that they currently do not perceive with regard to the expectation gap. In order to integrate the different stakeholders in the bio-economy development instead of confronting them with opaque legislation making, it is important to clearly communicate not only the opportunities but also the requirements that come along with the implementation of a bio-economy.