bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between iron deficiency anaemia and complementary feeding in children under 2 years assisted by a Conditional Cash Transfer programme
Authors: Mendes Marília Moura e , Marçal Giovana de Montemor , Fragoso Manuela Di Guaraldi Mafra , Florêncio Telma Maria de Menezes Toledo , Bueno Nassib Bezerra , Clemente Ana Paula Grotti 
Published: August 2020

AbstractObjective:To evaluate the association between Fe deficiency anaemia (IDA) and complementary feeding in children under 2 years old assisted by the Conditional Cash Transfer programme, Bolsa Família (BFP).Design:Cross-sectional study. Data were obtained through a standardised form, questionnaire to assess the eating habits of children under 2 years of age, capillary Hb (HemoCue®) and the Brazilian Household Food Insecurity Measurement Scale. Associations were calculated using hierarchical Poisson regression, adjusted at the last level by socio-economic, demographic and environmental variables from previous hierarchical levels.Setting:Six municipalities from the State of Alagoas, Brazil.Participants:Children aged 6–24 months assisted by BFP.Results:A total of 1604 children were evaluated, among whom 58·1 % had anaemia. A higher number of food groups consumed (prevalence ratio (PR) = 0·97; 95 % CI 0·95, 0·99; P = 0·009), the consumption of dairy (PR = 0·86; 95 % CI 0·79, 0·84; P = 0·001) and meat (PR = 0·90; 95 % CI 0·83, 0·99; P = 0·030) in addition to bottle feeding (PR = 0·88; 95 % CI 0·82, 0·96; P = 0·004) were associated with a lower prevalence of IDA.Conclusions:IDA is still a serious public health problem in children under 2 years old assisted by BFP in Alagoas. We highlight the importance of promoting complementary feeding based on a diversified dietary intake, as well strengthening prophylactic supplementation programmes to increase children’s adherence in conjunction with the implementation of food and nutrition education to help reduce the prevalence of this condition.
The Electrician, the Magician and the Nervous Conductor
Authors: Brittan Francesca 
Published: August 2020

Berlioz's essay ‘Le chef d'orchestre, théorie de son art’ (1855) was among the first and most widely disseminated attempts to describe the art of modern conducting. Drawing together technical with literary and scientific language, it aimed to capture the relationship between leaders and players and, more broadly, the modes of animation underpinning nineteenth-century orchestral performance. Central to the essay are notions of electricity – animal, artificial and mesmeric. For Berlioz, the conductor's job is no longer simply to marshal his orchestral troops but to galvanize them: ‘his inner flame warms them, his electricity charges them.’ Here, I examine the medical and physical technologies that underpinned these descriptions – the ways in which podium conducting became newly intertwined with theories of bioelectricity, notions of spiritual or metaphysical ‘spark’, and emerging forms of electrical communication that rewired European conceptions of the body politic.In Part I, I examine the ‘electric baton’ which allowed Berlioz to control the enormous orchestral forces of his 1855 Exposition Universelle concerts, generating a quasi-telegraphic network with imperialist resonances. Part II examines the role of nervous electricity in Berlioz's accounts of conducting, and his conception of music itself as a charged substance. Part III draws technological and medical discourses into conversation with magical cultures, showing how notions of nervous power (and peril) united Berlioz, Mesmer and the famous Robert-Houdin. The new romantic conductor, as I conclude, was a figure poised at the intersection of medicine, electric technology, and a newly charged spirituality.
The cost of mental disorders: a systematic review
Authors: Christensen M. K. , Lim C. C. W. , Saha S. , Plana-Ripoll O. , Cannon D. , Presley F. , Weye N. , Momen N. C. , Whiteford H. A. , Iburg K. M. , McGrath J. J. 
Published: August 2020

Abstract

Aims
To identify and synthesise the literature on the cost of mental disorders.

Methods
Systematic literature searches were conducted in the databases PubMed, EMBASE, Web of Science, EconLit, NHS York Database and PsychInfo using key terms for cost and mental disorders. Searches were restricted to January 1980–May 2019. The inclusion criteria were: (1) cost-of-illness studies or cost-analyses; (2) diagnosis of at least one mental disorder; (3) study population based on the general population; (4) outcome in monetary units. The systematic review was preregistered on PROSPERO (ID: CRD42019127783).

Results
In total, 13 579 potential titles and abstracts were screened and 439 full-text articles were evaluated by two independent reviewers. Of these, 112 articles were included from the systematic searches and 31 additional articles from snowball searching, resulting in 143 included articles. Data were available from 48 countries and categorised according to nine mental disorder groups. The quality of the studies varied widely and there was a lack of studies from low- and middle-income countries and for certain types of mental disorders (e.g. intellectual disabilities and eating disorders). Our study showed that certain groups of mental disorders are more costly than others and that these rankings are relatively stable between countries. An interactive data visualisation site can be found here: https://nbepi.com/econ.

Conclusions
This is the first study to provide a comprehensive overview of the cost of mental disorders worldwide.
Impacts of repeated glyphosate use on growth of orchard crops
Authors: Osipitan O. Adewale , Yildiz-Kutman Bahar , Watkins Seth , Brown Patrick H. , Hanson Bradley D. 
Published: August 2020

AbstractGlyphosate is an important component of herbicide programs in orchard crops in California. It can be applied alone or in tank-mix combinations under the crop rows or to the entire field and often is used multiple times each year. There has been speculation about the potential impacts of repeated use of glyphosate in perennial crop systems, because of uptake from shallow root systems or indirectly because of effects on nutrient availability in soil. To address these concerns, research was conducted from 2013 to 2020 on key orchard crops to evaluate tree response to glyphosate regimens. Almond, cherry, and prune were evaluated in separate experiments. In each crop, the experimental design was a factorial arrangement of two soil types, four glyphosate rates (0, 1.1, 2.2, and 4.4 kg ae ha−1, applied three times annually), and two post-glyphosate application irrigation treatments. In the first 2 yr of the study, there was no clear impact of the glyphosate regimens on shikimate accumulation or leaf chlorophyll content, which suggested no direct effect on the crop. In the seventh year of the study, after six consecutive years of glyphosate application to the orchard floors, there were no negative impacts of glyphosate application on leaf nutrient concentration or on cumulative trunk growth in any of the three orchard crops. Lack of a negative growth impact even at the highest treatment rate, which included 18 applications of glyphosate totaling nearly 80 kg ae ha−1 glyphosate over the course of the experiment suggest there is not likely a significant risk to tree health of judicious use of the herbicide in these production systems. Given the economic importance of orchard crops in California, and grower and industry concerns about pesticides generally and specifically about glyphosate, these findings are timely contributions to weed management concerns in perennial specialty crops.
The influence of soybean population and POST herbicide application timing on in-season and subsequent-season Palmer amaranth (Amaranthus palmeri) control and economic returns
Authors: Mahoney Denis J. , Jordan David L. , Hare Andrew T. , Roma-Burgos Nilda , Jennings Katherine M. , Leon Ramon G. , Vann Matthew C. , Everman Wesley J. , Cahoon Charles W. 
Published: August 2020

AbstractOverreliance on herbicides for weed control has led to the evolution of herbicide-resistant Palmer amaranth populations. Farm managers should consider the long-term consequences of their short-term management decisions, especially when considering the soil weed seedbank. The objectives of this research were to (1) determine how soybean population and POST herbicide application timing affects in-season Palmer amaranth control and soybean yield, and (2) how those variables influence Palmer amaranth densities and cotton yields the following season. Soybeans were planted (19-cm row spacing) at a low-, medium-, and high-density population (268,000, 546,000, and 778,000 plants ha–1, respectively). Fomesafen and clethodim (280 and 210 g ai ha–1, respectively) were applied at the VE, V1, or V2 to V3 soybean growth stage. Nontreated plots were also included to assess the effect of soybean population alone. The following season, cotton was planted into these plots so as to understand the effects of soybean planting population on Palmer amaranth densities in the subsequent crop. When an herbicide application occurred at the V1 or V2 to V3 soybean stage, weed control in the high-density soybean population increased 17% to 23% compared to the low-density population. Economic return was not influenced by soybean population and was increased 72% to 94% with herbicide application compared to no treatment. In the subsequent cotton crop, Palmer amaranth densities were 24% to 39% lower 3 wk after planting when following soybean sprayed with herbicides compared to soybean without herbicides. Additionally, Palmer amaranth densities in cotton were 19% lower when soybean was treated at the VE stage compared to later stages. Thus, increasing soybean population can improve Palmer amaranth control without adversely affecting economic returns and can reduce future weed densities. Reducing the weed seedbank and selection pressure from herbicides are critical in mitigating resistance evolution.
Conceptual Model of Arsenic Mobility in the Shallow Alluvial Aquifers Near Venice (Italy) Elucidated Through Machine Learning and Geochemical Modeling
Authors: Dalla Libera Nico , Pedretti Daniele , Tateo Fabio , Mason Leonardo , Piccinini Leonardo , Fabbri Paolo 
Published: August 2020

AbstractThis work proposed a novel method to elucidate the controls of As mobility in complex aquifers based on an unsupervised machine learning algorithm, Self‐Organizing Map (SOM), and process‐based geochemical modeling. The approach is tested in the shallow aquifers of the Venetian Alluvial Plain (VAP) near Venice, Italy, where As concentrations seasonally and locally exceed recommended drinking water limits. SOM was fed using information from two geochemical surveys on eight VAP boreholes, and continuous reading of hourly groundwater head levels and weekly geochemical analyses from three VAP boreholes between mid‐October 2017 and end of January 2018. The SOM analysis is consistent with redox‐controlled dissolution‐precipitation hydrous ferric oxides (HFOs) as a key control of As mobility in the aquifer. Dissolved As is positively correlated to Fe and
and negatively to the oxidizing‐reducing potential (ORP). Negative correlation between As and groundwater head levels suggests a redox control by rainfall‐driven recharge, which adds oxidants to the aquifer while progressively attenuating As. This mechanism is tested using process‐based geochemical modeling, which simulates different transport modalities of oxidants entering the aquifer. Starting from reducing aquifer conditions, the model reproduces correctly the observed ORP and the trends in As and Fe, when the function describing the occurrence of oxidizing events scales according to the temporal occurrence of rainfall events. Heterogeneity can strongly control the local‐scale effectiveness of recharge as a natural As attenuating factor, requiring a different model analysis to be properly assessed and to be developed in a follow‐up study.
Evolution of the Upper Ocean Stratification in the Japan Sea Since the Last Glacial
Authors: Wu Yonghua , Shi Xuefa , Gong Xun , Jian Zhimin , Zou Jianjun , Liu Yanguang , Lohmann Gerrit , Gorbarenko Sergey A. , Tiedemann Ralf , Lembke‐Jene Lester 
Published: August 2020

AbstractPaleoceanographic evidence commonly indicates that Last Glacial Maximum surface temperatures in the Japan Sea were comparable to modern conditions, in striking difference to colder neighboring regions. Here, based on a core from the central Japan Sea, our results show similar UK′37‐ and TEXL86‐derived temperatures between 24.7 and 16.3 ka BP, followed by an abrupt divergence at ~16.3 ka BP and a weakening of divergence after ~8.7 ka BP. We attribute this process to a highly stratified glacial upper ocean controlled by the East Asian Summer Monsoon, increasing thermal gradient between surface and subsurface layers during the deglaciation and the intrusion of Tsushima Warm Current since the mid‐Holocene, respectively. Therefore, we suggest that threshold‐like changes in upper‐ocean temperatures linked to sea level rise and monsoon dynamics, rather than just sea surface temperatures, play a critical role in shaping the thermal and ventilation history of this NW Pacific marginal sea.
Physical Properties and Gas Hydrate at a Near‐Seafloor Thrust Fault, Hikurangi Margin, New Zealand
Authors: Cook Ann E. , Paganoni Matteo , Clennell Michael Benedict , McNamara David D. , Nole Michael , Wang Xiujuan , Han Shuoshuo , Bell Rebecca E. , Solomon Evan A. , Saffer Demian M. , Barnes Philip M. , Pecher Ingo A. , Wallace Laura M. , LeVay Leah J. , Petronotis Katerina E. 
Published: August 2020

AbstractThe Pāpaku Fault Zone, drilled at International Ocean Discovery Program (IODP) Site U1518, is an active splay fault in the frontal accretionary wedge of the Hikurangi Margin. In logging‐while‐drilling data, the 33‐m‐thick fault zone exhibits mixed modes of deformation associated with a trend of downward decreasing density, P‐wave velocity, and resistivity. Methane hydrate is observed from ~30 to 585 m below seafloor (mbsf), including within and surrounding the fault zone. Hydrate accumulations are vertically discontinuous and occur throughout the entire logged section at low to moderate saturation in silty and sandy centimeter‐thick layers. We argue that the hydrate distribution implies that the methane is not sourced from fluid flow along the fault but instead by local diffusion. This, combined with geophysical observations and geochemical measurements from Site U1518, suggests that the fault is not a focused migration pathway for deeply sourced fluids and that the near‐seafloor Pāpaku Fault Zone has little to no active fluid flow.
Impact of the Oyashio Extension SST Front on Synoptic Variability of Oceanic Low‐Level Cloud in Summertime Based on WRF Numerical Simulation
Authors: Takahashi Naoya , Hayasaka Tadahiro , Manda Atsuyoshi , Schneider Niklas 
Published: August 2020

AbstractThe sea surface temperature (SST) front in the North Pacific (NP) has a potential to modulate the atmospheric boundary layer and cloud properties within it. We investigated the impact of the SST gradient along with the Oyashio Extension on low‐level cloud properties during summertime based on a Weather Research and Forecasting (WRF) numerical simulation. To reveal the SST gradient impact, we conducted two experiments with different boundary conditions from July to August for 3 years from 2014 to 2016: the first with 0.25° daily SST data (CTL experiment) and the second with spatially smoothed SST without SST frontal characteristics (SMO experiment). The period mean cloud water mixing ratio of marine fog on the northern flank of the front in the CTL experiment was larger than that in the SMO experiment by about 20% of the mean value. The SST front affected not only the mean state but also the synoptic variability of the marine fog, and the magnitude of the effects depended on the meridional wind across the SST front. We found two competing physical processes modulating the marine fog on the northern flank. First, a local cold SST anomaly reduced the saturated water vapor pressure near the surface, which is favorable for fog formation (SST anomaly effect). Second, warm temperature advection from southern to northern flanks suppressed the fog formation, and the suppression was effective when the horizontal gradient of SST anomaly was large (SST frontal effect). Our results indicated the importance of the SST gradient in summertime Oyashio Extension for the marine fog formation.
A novel mitochondrial amidoxime reducing component 2 is a favorable indicator of cancer and suppresses the progression of hepatocellular carcinoma by regulating the expression of p27
Authors: Wu Dehai , Wang Yan , Yang Guangchao , Zhang Shugeng , Liu Yao , Zhou Shuo , Guo Hongrui , Liang Shuhang , Cui Yifeng , Zhang Bo , Ma Kun , Zhang Congyi , Liu Yufeng , Sun Linmao , Wang Jiabei , Liu Lianxin 
Published: August 2020

AbstractHepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might be a key diver for the development of HCC. The mitochondrial amidoxime reducing component 2 (MARC2) as a newly discovered molybdenum enzyme was downregulated in human HCC tissues and HCC cells. Downregulated MARC2 was significantly associated with clinicopathological characteristics of HCC, such as tumor size, AFP levels, and tumor grade and was an independent risk factor of poor prognosis. Both in vitro and in vivo studies suggested that MARC2 suppressed the progression of HCC by regulating the protein expression level of p27. The Hippo signaling pathway and RNF123 were required for this process. Moreover, MARC2 regulated expression of HNF4A via the Hippo signaling pathway. HNF4A was recruited to the promoter of MARC2 forming a feedback loop. MARC2 levels were downregulated by methylation. We demonstrated the prognostic value of MARC2 in HCC and determined the mechanism by which MARC2 suppressed the progression of HCC in this study. These findings may lead to new therapeutic targets for HCC.
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Authors: Lim Yoon , De Bellis Dylan , Sandow Jarrod J. , Capalbo Luisa , D’Avino Pier Paolo , Murphy James M. , Webb Andrew I. , Dorstyn Loretta , Kumar Sharad 
Published: August 2020

AbstractMitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and catalytic function of caspase-2 are key steps in MC to trigger apoptosis and/or cell cycle arrest of mitotically defective cells. However, the molecular mechanisms that regulate caspase-2 activation and its function are unclear. Here, we identify six new phosphorylation sites in caspase-2 and show that a key mitotic kinase, Aurora B kinase (AURKB), phosphorylates caspase-2 at the highly conserved residue S384. We demonstrate that phosphorylation at S384 blocks caspase-2 catalytic activity and apoptosis function in response to mitotic insults, without affecting caspase-2 dimerisation. Moreover, molecular modelling suggests that phosphorylation at S384 may affect substrate binding by caspase-2. We propose that caspase-2 S384 phosphorylation by AURKB is a key mechanism that controls caspase-2 activation during mitosis.
Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC
Authors: Li Sijie , Wu Di , Jia Hongyao , Zhang Zhiru 
Published: August 2020

AbstractAs a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in TNBC tissues and cells. Then, the results of functional assays disclosed that BAALC facilitated cell proliferation, invasion, and epithelial–mesenchymal transition (EMT) processes, but repressed cell apoptosis in TNBC. Next, miR-380–3p was identified as the upstream of BAALC in TNBC cells. Moreover, LRRC75A-AS1 (also named small nucleolar RNA host gene 29: SNHG29) was verified to act as the sponge of miR-380–3p to elevate BAALC expression in TNBC. Besides, LRRC75A-AS1 could negatively regulate miR-380–3p but positively regulate BAALC expression. Finally, rescue assays elucidated that LRRC75A-AS1 facilitated cell proliferation, invasion, and EMT processes in TNBC by targeting miR-380–3p/BAALC pathway. Taken together, our study revealed a novel ceRNA network of LRRC75A-AS1/miR-380–3p/BAALC in accelerating TNBC development, indicating new promising targets for TNBC treatment.
Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis
Authors: Strippoli Raffaele , Sandoval Pilar , Moreno-Vicente Roberto , Rossi Lucia , Battistelli Cecilia , Terri Michela , Pascual-Antón Lucía , Loureiro Marta , Matteini Francesca , Calvo Enrique , Jiménez-Heffernan José Antonio , Gómez Manuel José , Jiménez-Jiménez Victor , Sánchez-Cabo Fátima , Vázquez Jesús , Tripodi Marco , López-Cabrera Manuel , del Pozo Miguel Ángel 
Published: August 2020

AbstractDespite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding as to how biomechanical signals are integrated with specific biochemical pathways to determine cell behaviour. Mesothelial-to-mesenchymal transition (MMT) markers colocalized with TGF-β1-dependent signaling and yes-associated protein (YAP) activation across biopsies from different pathologies exhibiting peritoneal fibrosis, supporting mechanotransduction as a central driving component of these class of fibrotic lesions and its crosstalk with specific signaling pathways. Transcriptome and proteome profiling of the response of mesothelial cells (MCs) to linear cyclic stretch revealed molecular changes compatible with bona fide MMT, which (i) overlapped with established YAP target gene subsets, and were largely dependent on endogenous TGF-β1 signaling. Importantly, TGF-β1 blockade blunts the transcriptional upregulation of these gene signatures, but not the mechanical activation and nuclear translocation of YAP per se. We studied the role therein of caveolin-1 (CAV1), a plasma membrane mechanotransducer. Exposure of CAV1-deficient MCs to cyclic stretch led to a robust upregulation of MMT-related gene programs, which was blunted upon TGF-β1 inhibition. Conversely, CAV1 depletion enhanced both TGF-β1 and TGFBRI expression, whereas its re-expression blunted mechanical stretching-induced MMT. CAV1 genetic deficiency exacerbated MMT and adhesion formation in an experimental murine model of peritoneal ischaemic buttons. Taken together, these results support that CAV1-YAP/TAZ fine-tune the fibrotic response through the modulation of MMT, onto which TGF-β1-dependent signaling coordinately converges. Our findings reveal a cooperation between biomechanical and biochemical signals in the triggering of MMT, representing a novel potential opportunity to intervene mechanically induced disorders coursing with peritoneal fibrosis, such as post-surgical adhesions.