bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation of Gastro-retentive Floating Tablets of Valsartan by 2 power 2 Factorial Designs: In vitro and In vivo Evaluations
Authors: Pamu Sandhya , C. V. S Subrahmanyam , K. S. K. Rao Patnaik 
Published: August 2020

An oral dosage form containing gastro-retentive floating tablets forms a stomach-specific drug delivery system for the treatment of hypertension. Valsartan belongs to the BCS class II (poo Classification System). It is desirable to improve the extent of bioavailability (23%). The objective of the present study was to apply design of experiment to optimize floating drug delivery of valsartan by employing 22 factorial design. Improvement of the aqueous solubility of valsartan was done by solid dispersions using hot melt extrusion technique. Plasdone S630 copovidone is a variable carrier and drug to carrier ratio of 1:2 was optimized. Valsartan floating tablets were prepared by employing factorial design (22), where HPMC K15M (X1) and pregelatinized starch (X2) were independent variables and drug dissolution was the dependent parameter (Y1) to prepare matrix tablets. The factorial analysis, steepest ascent method was utilized for obtaining optimized formulation. In vitro evaluation, In vivo radiographic study and biopharmaceutical analysis in rabbits for valsartan optimized formulation (FT-5). Floating lag time (FLT) for valsartan optimized formulation (FT-5) was 15 s and total floating time (TFT) of the tablets was about 33 h, which was satisfactory. A four-point (1 h, 4 h, 8 h and 16 h) dissolution analysis gave satisfactory dissolution profile up to 24 h. The release kinetics of valsartan optimized formulation (FT-5) followed zero order and the release mechanism was found to be Korsemeyer Peppas model, i.e. swelling type. The dissolution efficiency for valsartan floating tablets was 1190.89% against the marketed formulation of 39.77%. The accelerated stability profile of valsartan optimized formulation (FT-5) was evaluated in terms of drug content and percent cumulative dissolution of valsartan in 24 h, in a 6 months study. In vivo X-ray image study for valsartan optimized formulation (FT-5) indicated the presence of intact tablet up to 12 h in gastric region of rabbit. The biopharmaceutical analysis in rabbits was conducted for valsartan optimized formulation (FT-5). The HPLC method was established and validated for the in vivo analysis. The Cmax was 453.2 ng/mL compared to that of the marketed tablets (522.4 ng/mL). The mean residence time (MRT) for the valsartan optimized formulation (FT-5) was 14.82 h as against 4 h for marketed tablet. The relative bioavailability of valsartan optimized formulation (FT-5) was 650% higher than the marketed tablet. To overcome the poor bioavailability of valsartan, it was suitably modified using hot-melt extrusion for improving therapeutic outcome. In conclusion, gastro-retentive drug delivery system is an excellent approach for improving the bioavailability of valsartan.
Mortality from Pulmonary Embolism by Clinical Severity
Authors: Asthana Arushi , Konar Niladri , Chakravorty Indranil 
Published: August 2020

Aim: To report all-cause and PE related short term mortality by clinical severity of PE and to identify any missed opportunities for thrombolysis. Background: Mortality related to pulmonary embolism varies widely in the reported literature even for the same clinical severity category of PE. Method: Electronic medical records of all patients presenting to a large tertiary care teaching hospital in London, between October 1, 2018, and January 16, 2020, who had a discharge diagnosis of acute pulmonary embolism were reviewed retrospectively. Results: There was no PE related mortality in the low-risk PE group. There was one PE related death in the submassive PE group (1.47% mortality on day 14 and day 30). Massive PE was associated with a 29.4% PE related mortality short-term mortality.
Revisiting MOA 2013-BLG-220L: A Solar-type Star with a Cold Super-Jupiter Companion
Authors: Vandorou Aikaterini , Bennett David P. , Beaulieu Jean-Philippe , Alard Christophe , Blackman Joshua W. , Cole Andrew A. , Bhattacharya Aparna , Bond Ian A. , Koshimoto Naoki , Marquette Jean-Baptiste 
Published: August 2020

Abstract
We present the analysis of high-resolution images of MOA-2013-BLG-220, taken with the Keck adaptive optics system six years after the initial observation, identifying the lens as a solar-type star hosting a super-Jupiter-mass planet. The masses of planets and host stars discovered by microlensing are often not determined from light-curve data, while the star–planet mass ratio and projected separation in units of Einstein ring radius are well measured. High-resolution follow-up observations after the lensing event is complete can resolve the source and lens. This allows direct measurements of flux, and the amplitude and direction of proper motion, giving strong constraints on the system parameters. Due to the high relative proper motion,

mas yr−1, the source and lens were resolved in 2019, with a separation of 77.1 ± 0.5 mas. Thus, we constrain the lens flux to

. By combining constraints from the model and Keck flux, we find the lens mass to be

at

. With a mass ratio of

the planet’s mass is determined to be

at a separation of

. The lens mass is much higher than the prediction made by Bayesian analysis that assumes all stars have an equal probability to host a planet of the measured mass ratio, and suggests that planets with mass ratios of a few times 10−3 are more common orbiting massive stars. This demonstrates the importance of high-resolution follow-up observations for testing theories like these.
APOGEE Data and Spectral Analysis from SDSS Data Release 16: Seven Years of Observations Including First Results from APOGEE-South
Authors: Jönsson Henrik , Holtzman Jon A. , Prieto Carlos Allende , Cunha Katia , García-Hernández D. A. , Hasselquist Sten , Masseron Thomas , Osorio Yeisson , Shetrone Matthew , Smith Verne , Stringfellow Guy S. , Bizyaev Dmitry , Edvardsson Bengt , Majewski Steven R. , Mészáros Szabolcs , Souto Diogo , Zamora Olga , Beaton Rachael L. , Bovy Jo , Donor John , Pinsonneault Marc H. , Poovelil Vijith Jacob , Sobeck Jennifer 
Published: August 2020

Abstract
The spectral analysis and data products in Data Release 16 (DR16; 2019 December) from the high-resolution near-infrared Apache Point Observatory Galactic Evolution Experiment (APOGEE)-2/Sloan Digital Sky Survey (SDSS)-IV survey are described. Compared to the previous APOGEE data release (DR14; 2017 July), APOGEE DR16 includes about 200,000 new stellar spectra, of which 100,000 are from a new southern APOGEE instrument mounted on the 2.5 m du Pont telescope at Las Campanas Observatory in Chile. DR16 includes all data taken up to 2018 August, including data released in previous data releases. All of the data have been re-reduced and re-analyzed using the latest pipelines, resulting in a total of 473,307 spectra of 437,445 stars. Changes to the analysis methods for this release include, but are not limited to, the use of MARCS model atmospheres for calculation of the entire main grid of synthetic spectra used in the analysis, a new method for filling “holes” in the grids due to unconverged model atmospheres, and a new scheme for continuum normalization. Abundances of the neutron-capture element Ce are included for the first time. A new scheme for estimating uncertainties of the derived quantities using stars with multiple observations has been applied, and calibrated values of surface gravities for dwarf stars are now supplied. Compared to DR14, the radial velocities derived for this release more closely match those in the Gaia DR2 database, and a clear improvement in the spectral analysis of the coolest giants can be seen. The reduced spectra as well as the result of the analysis can be downloaded using links provided on the SDSS DR16 web page.
Wave Pressure and Energy Cascade Rate of Kink Waves Computed with Elsässer Variables
Authors: Van Doorsselaere Tom , Li Bo , Goossens Marcel , Hnat Bogdan , Magyar Norbert 
Published: August 2020

Abstract
Numerical simulations have revealed a new type of turbulence of unidirectional waves in a plasma that is perpendicularly structured, named uniturbulence. For this new type of turbulence, the transverse structuring modifies the upward propagating wave to have both Elsässer variables, leading to the well-known perpendicular cascade. In this paper, we study an analytical description of the nonlinear evolution of kink waves in a cylindrical flux tube that are prone to uniturbulence. We show that they lead to a nonlinear cascade for both propagating and standing waves. We calculate explicit expressions for the wave pressure and energy cascade rate. The computed damping rate

depends on the density contrast of the flux tube and the background plasma and is inversely proportional to the amplitude of the kink wave. The dependence on the density contrast shows that it plays a role especially in the lower solar corona. These expressions may be added in Alfvén wave driven models of the solar atmosphere (such as the Alfvén Wave Solar Model (AWSOM)), modifying it to UAWSOM (Uniturbulence and the Alfvén Wave Solar Model).
GASP XXX. The Spatially Resolved SFR–Mass Relation in Stripping Galaxies in the Local Universe
Authors: Vulcani Benedetta , Poggianti Bianca M. , Tonnesen Stephanie , McGee Sean L. , Moretti Alessia , Fritz Jacopo , Gullieuszik Marco , Jaffé Yara L. , Franchetto Andrea , Tomičić Neven , Mingozzi Matilde , Bettoni Daniela , Wolter Anna 
Published: August 2020

Abstract
The study of the spatially resolved star formation rate–mass (

–

) relation gives important insights on how galaxies assemble at different spatial scales. Here, we present an analysis of the

–

of 40 local cluster galaxies undergoing ram-pressure stripping drawn from the GAs Stripping Phenomena in galaxies (GASP) sample. Considering their integrated properties, these galaxies show an SFR enhancement with respect to undisturbed galaxies of similar stellar mass; we now exploit spatially resolved data to investigate the origin and location of the excess. Even on ∼1kpc scales, stripping galaxies present a systematic enhancement of

(∼0.35 dex at

=

) at any given

compared to their undisturbed counterparts. The excess is independent of the degree of stripping and of the amount of star formation in the tails, and it is visible at all galactocentric distances within the disks, suggesting that the star formation is most likely induced by compression waves from ram pressure. Such excess is larger for less massive galaxies and decreases with increasing mass. As stripping galaxies are characterized by ionized gas beyond the stellar disk, we also investigate the properties of 411 star-forming clumps found in the galaxy tails. At any given stellar mass density, these clumps are systematically forming stars at a higher rate than in the disk, but differences are reconciled when we just consider the mass formed in the last few 108 yr ago, suggesting that on these timescales, the local mode of star formation is similar in the tails and in the disks.
On the Magnetic Fields, Beaming Fractions, and Fastness Parameters of Pulsating Ultraluminous X-Ray Sources
Authors: Erkut M. H. , Türkoğlu M. M. , Ekşi K. Y. , Alpar M. A. 
Published: August 2020

Abstract
The discovery of pulsating ultraluminous X-ray sources (PULX) suggests that neutron stars are presumably common within the ultraluminous X-ray source (ULX) population though the majority of the population members currently lack pulsations. These systems are likely to host neutron stars accreting mass at super-Eddington (supercritical) rates from their massive companion in high-mass X-ray binaries. Taking into account the spherization of the accretion flow in the supercritical regime, the beaming of X-ray emission, and the reduction of the scattering cross section in a strong magnetic field, we infer the ranges for the neutron-star surface magnetic dipole field strengths, beaming fractions, and fastness parameters in the PULX M82 X-2, ULX NGC 5907, ULX NGC 7793 P13, NGC 300 ULX1, M51 ULX-7, NGC 1313 X-2, and Swift J0243.6+6124 from a set of conditions based on a variety of combinations of different spin and luminosity states. Using the observed spin-up rates under the critical luminosity condition, we estimate the surface-field strengths in the ∼1011–1013 G range for all PULX. In general, the results of our analysis under the subcritical luminosity condition indicate surface-field strengths in the ∼1011–1015 G range. We argue that PULX do not require magnetar-strength surface dipole fields if beaming is taken into account, yet the fields are strong enough for the neutron stars in ULX to magnetically channel the accretion flow in supercritical accretion disks.
Generalized General Relativistic Magnetohydrodynamic Equations for Plasmas of Active Galactic Nuclei in the Era of the Event Horizon Telescope
Authors: Koide Shinji 
Published: August 2020

Abstract
The generalized general relativistic magnetohydrodynamic (generalized GRMHD) equations have been used to study specific relativistic plasma phenomena, such as relativistic magnetic reconnection or wave propagation modified by nonideal MHD effects. However, the Θ term in the generalized Ohm’s law, which expresses the energy exchange between two fluids composing a plasma, has yet to be determined in these equations. In this paper, we determine the Θ term based on the generalized relativistic Ohm’s law itself. This provides closure of the generalized GRMHD equations, yielding a closed system of the equations of relativistic plasma. According to this system of equations, we reveal the characteristic scales of nonideal MHD phenomena and clarify the applicable condition of the ideal GRMHD equations. We evaluate the characteristic scales of the nonideal MHD phenomena in the M87* plasma using the Event Horizon Telescope observational data.
Recombination Lines and Molecular Gas from Hypercompact H ii regions in W51 A
Authors: Rivera-Soto Rudy , Galván-Madrid Roberto , Ginsburg Adam , Kurtz Stan 
Published: August 2020

Abstract
We present a detailed characterization of the population of compact radio-continuum sources in W51 A using subarcsecond Very Large Array and Atacama Large Millimeter/submillimeter Array observations. We analyze their 2 cm continuum, the recombination lines (RLs) H77α and H30α, and the lines of

,

, and

. We derive diameters for 10/20 sources in the range D ∼ 10−3 to ∼10−2 pc, thus placing them in the regime of hypercompact H ii regions (HC H ii’s). Their continuum-derived electron densities are in the range n
e ∼ 104 –105 cm−3, lower than typically considered for HC H ii’s. We combined the RL measurements and independently derived n
e, finding the same range of values but significant offsets for individual measurements between the two methods. We find that most of the sources in our sample are ionized by early B-type stars, and a comparison of n
e versus D shows that they follow the inverse relation previously derived for ultracompact (UC) and compact H ii’s. When determined, the ionized-gas kinematics is always (7/7) indicative of outflow. Similarly, 5 and 3 out of the 8 HC H ii’s still embedded in a compact core show evidence for expansion and infall motions in the molecular gas, respectively. We hypothesize that there could be two different types of hypercompact (D < 0.05 pc) H ii regions: those that essentially are smaller, expanding UC H ii’s; and those that are also hyperdense (n
e > 106 cm−3), probably associated with O-type stars in a specific stage of their formation or early life.
Destruction of Molecular Hydrogen Ice and Implications for 1I/2017 U1 (‘Oumuamua)
Authors: Hoang Thiem , Loeb Abraham 
Published: August 2020

Abstract
The first interstellar object observed in our solar system, 1I/2017 U1 (‘Oumuamua), exhibited a number of peculiar properties, including extreme elongation and acceleration excess. Recently, Seligman & Laughlin proposed that the object was made out of molecular hydrogen (H2) ice. The question is whether H2 objects could survive their travel from the birth sites to the solar system. Here we study destruction processes of icy H2 objects through their journey from giant molecular clouds (GMCs) to the interstellar medium (ISM) and the solar system, owing to interstellar radiation, gas and dust, and cosmic rays. We find that thermal sublimation due to heating by starlight can destroy ‘Oumuamua-size objects in less than 10 Myr. Thermal sublimation by collisional heating in GMCs could destroy H2 objects of ‘Oumuamua-size before their escape into the ISM. Most importantly, the formation of icy grains rich in H2 is unlikely to occur in dense environments because collisional heating raises the temperature of the icy grains, so that thermal sublimation rapidly destroys the H2 mantle before grain growth.
Présentation : le néologisme orgueilleux
Authors: Ragni Alice , Carraud Vincent 
Published: August 2020

La présentation de ce dossier l’inscrit dans les recherches récentes sur l’origine moderne du mot ontologia , sur son historiographie, sur les apories de la métaphysique scolastique dont l’ontologie hérite, sur son contexte initialement calviniste, sur les moments principaux de son développement et sur la thèse fondamentale qui, réduisant l’étant à un pur concept, l’identifie au pensable – jusqu’à la fascination ambivalente de Kant, qui, avant que la Critique de la raison pure n’entende substituer au nom orgueilleux d’ontologie le nom modeste d’une analytique de l’entendement pur, avait envisagé, dans les années 1770, son remplacement par une anthropologie transcendantale.
Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
Authors: Villegas-Mendez Ana , Khandelwal Garima , McGowan Lucy M. , Dookie Rebecca S. , Haley Michael J. , George Charlotte , Sims David , Lord Graham M. , Sinclair Linda V. , Jenner Richard G. , Couper Kevin N. 
Published: August 2020

Abstract
CD4+ T cell functional inhibition (exhaustion) is a hallmark of malaria and correlates with impaired parasite control and infection chronicity. However, the mechanisms of CD4+ T cell exhaustion are still poorly understood. In this study, we show that Ag-experienced (Ag-exp) CD4+ T cell exhaustion during Plasmodium yoelii nonlethal infection occurs alongside the reduction in mammalian target of rapamycin (mTOR) activity and restriction in CD4+ T cell glycolytic capacity. We demonstrate that the loss of glycolytic metabolism and mTOR activity within the exhausted Ag-expCD4+ T cell population during infection coincides with reduction in T-bet expression. T-bet was found to directly bind to and control the transcription of various mTOR and metabolism-related genes within effector CD4+ T cells. Consistent with this, Ag-expTh1 cells exhibited significantly higher and sustained mTOR activity than effector T-bet– (non-Th1) Ag-expT cells throughout the course of malaria. We identified mTOR to be redundant for sustaining T-bet expression in activated Th1 cells, whereas mTOR was necessary but not sufficient for maintaining IFN-γ production by Th1 cells. Immunotherapy targeting PD-1, CTLA-4, and IL-27 blocked CD4+ T cell exhaustion during malaria infection and was associated with elevated T-bet expression and a concomitant increased CD4+ T cell glycolytic metabolism. Collectively, our data suggest that mTOR activity is linked to T-bet in Ag-expCD4+ T cells but that reduction in mTOR activity may not directly underpin Ag-expTh1 cell loss and exhaustion during malaria infection. These data have implications for therapeutic reactivation of exhausted CD4+ T cells during malaria infection and other chronic conditions.
Factors Determining Continuous Tractor Use in Benin Republic
Authors: Dayou Ephrème Dossavi , Ajav Emmanuel A. , Zokpodo K.L. Barnabé , Bamgboye A. Isaac , Glèlè Kakaï L. Romain 
Published: August 2020

This study investigated the factors determining continuous tractor use in Benin. A multi stage sampling procedure was used to select tractor users in the country. A total of 203 households using agricultural machinery were surveyed through interviews and using a structured questionnaire. The information concerned socioeconomic characteristics, the equipment used and agricultural production. The logit model was used for data analysis. About 75% of tractor owners use it for service delivery, while 71.4% of them possess their own land. Continuous use of tractor is significantly influenced by the number of hours for one hectare tilled, the total area tilled per year as well as the tractor age. Moreover, the tractor brands available in the country also influenced tractor use. The hierarchized failures were hydraulic lifting pump (16.4%), fuel filter (14.6%), clutch disc failure (9.9%), breakage of plough (8.8%) and injection pump (7.6%). The future of agricultural equipment use can now be anticipated and take action to deal with any tractor use difficulties for sustainable agricultural extension in Benin.
Keywords: Farm machinery, adoption, failure, Benin Republic.
Physicochemical Characteristics, Identification of Fungi and Optimization of Different Parameters for Degradation of Dye from Tannery Effluent
Authors: Ben Ashley B. , Amutha E. , Pushpalaksmi E , Jenson Samraj J. , Annadurai G. 
Published: August 2020

This study was carried out to find out the qualities of tannery effluents with the assessment of physicochemical parameters of effluent, isolation, and identification of fungi and their optimization of different parameters on dye decolorization. In the present study, various physicochemical parameters such as Color, Odor, pH, EC, TSS, TDS, BOD, COD, Chromium, Copper, Chloride, and Sodium of untreated tannery effluent wasstudied. The results of the parameters showed that the effluent was blackish with a disagreeable odor, alkaline in pH with a high organic and inorganic loads such as EC, TDS, BOD, COD, TSS, Chromium, Copper, Chloride and Sodium. The physicochemical parameters were determined as per the standards prescribed by CPCB. Four fungal species were isolated and identified by LPCB staining namely Aspergillus niger, Aspergillus flavus, Penicillium citrinum, and Curvularia lunata. To test the activity of these fungi on different dyes, experiments were carried out for the optimization of different parameters. The maximum decolorization of dye was achieved by Aspergillus niger. From this study, it was found that the maximum biotransformation of dye effluent can help to solve the pollution problem.
Keywords: physicochemical parameters, fungal isolation, and identification, Aspergillus niger,
Delineation of Near-Surface Structural Features Suitable for Groundwater Accommodation Using 1-D and 2-D Resistivity Methods in Igarra, Akoko-Edo, Southwestern Nigeria
Authors: Salami A.S. , Babafemi E.M. 
Published: August 2020

Electrical resistivity methods using dipole-dipole and Schlumberger configurations of Vertical Electrical Sounding (VES) were carried out to evaluate the near-surface structural and lithological features suitable for groundwater development in parts of Igarra, Southwestern Nigeria. Two profiles with lengths of greater than 350m were carried out. A total of fifteen sounding locations along the profile lines were occupied. Dipole-dipole data were interpreted using DiprofWin software while interpretation of the VES data followed two stages of qualitative and quantitative data interpretation using Resist software. Dipole-dipole interpretation results indicate the occurrence of local fractures while VES interpretation results reveal the typical basement rock profile ranging from topsoil, lateritic sand, weathered front, fractured to fresh basement. The significant variations in terms of persistence and thicknesses of these basement vertical rock profiles were revealed by the geoelectrical correlation panels, which indicate typical basement inhomogeneities over short distances. The local structural domains, the weathered front (where thick) and the fractured basement are demonstrably potential sources of groundwater, at least for domestic and small scale enterprises in this part of Igarra.
Keywords: 2-D Pseudosection, Dipole-dipole, Fracture Basement, Vertical Electrical Sounding