bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the 3D printout filling parameter on the impact strength of elements made with the FDM method
Authors: Korga S , Barszcz M , Zgryza Ł 
Published: December 2019

AbstractThe paper discusses the aspects of potential use of 3D printing technology in the process of manufacturing elements with different layer fillings. In 3D printing technology, the denser the percentage of filling a material, the higher the mechanical strength of a given element. However, in the literature on the subject, the dependence on these parameters for additive technology has not been unequivocally determined. Therefore, the aim of the study is to find a correlation between the internal structure of the elements understood as a percentage of filling the material produced by 3D printing technology and the impact strength achieved by these elements. To carry out the research process, sets of polymeric samples were prepared using 3D FDM printing. The shape and dimensions of the samples were determined in accordance with the PN-EN 10045-1 standard. The samples were made by means of the Printo H3 device with a closed working chamber, using ABS polymer filament. The samples were filled with a percentage interval of 10%. Impact strength tests of polymeric samples were carried out on a Charpy hammer stand adapted for this purpose. In this way, the results concerning the breaking energy were collected for particular groups of samples. The collected data allowed us to determine the relationship between the percentage of filling the sample and the energy absorbed by the sample. The results provided the basis for conclusions and recommendations regarding one of the most important technological parameters – the percentage of printed element filling.
Influence of IT outsourcing on selected groups of stakeholders (original research)
Authors: Sloniec J 
Published: December 2019

Abstract
This paper reports on the study conducted to determine the stakeholders of information technology outsourcing (ITO) and to the impact that IT outsourcing exerts on them. Six groups of ITO stakeholders were defined: vendor, customer, employees of supplier and customer, national labour market, national economy. In the study, employees of 200 large Polish and foreign companies operating in Poland were surveyed. The results indicated both positive and negative impact of ITO on its stakeholders: positive and negative on the customer and positive for the customer employees, which were subsequently correlated in search for conclusions The originality of the paper consists in that an extensive original study has led to defining ITO stakeholders and determining the impact of IT outsourcing on them, clarifying the positive and negative impact of ITO on customer and employees, and the correlation between the factors of the positive/negative impact of ITO on the customer. The results demonstrate that with the increase in the benefits of IT outsourcing (factors of the positive impact of outsourcing on the customer), the risks associated with it (factors of the negative impact of outsourcing on the customer) grow. This is further confirmed by a high and very high positive correlation between these values.
A cross-sectional survey of the perspectives of older people in the Scottish Highlands on the management of their chronic pain
Authors: Stewart Derek , Rushworth Gordon , Bailey Nicola , Pfleger Sharon , Jebara Tesnime , Munro Kim , Youngson Elaine , Wilson Martin , MacLeod John , Cunningham Scott 
Published: December 2019

Abstract

Background
Although there is evidence of suboptimal outcomes in older people with chronic pain, little emphasis has been placed on those in remote and rural settings.

Objective
To describe the perspectives of older people in the Scottish Highlands on their chronic pain management.

Design
Cross-sectional survey.

Setting
NHS Highland, the most remote and rural geographical health board in Scotland.

Subjects
Home-dwelling members of the public aged ≥70 years.

Methods
Anonymised questionnaires were mailed to a random sample of 1800 older people. Questionnaire items were demographics, nature of any chronic pain, management regimens and perceived effectiveness. Validated scales were the Pain Disability Questionnaire and the Tampa Scale for Kinesiophobia.

Results
Adjusted response rate was 39.3% (709/1755). One-quarter (25.0%, n = 177) were experiencing chronic pain, being more likely to live in deprived areas (P &lt; 0.05). Median pain intensity was 6 (IQR 4–7, 10 high), causing distress (median 5, IQR 3–7). Respondents largely consulted GPs (66.1%, n = 117) with a minority (16.4%, n = 29) referred to a specialist pain clinic and few consulting other health professionals. Over three quarters (78.0%, n = 138) were receiving prescribed medicines, most commonly paracetamol, alone (35.6%, n = 63) or in combination with opioids (16.4%, n = 29). One-third (31.6%, n = 56) expressed a desire for more effective medicines; few reported using any non-pharmacological therapies. The median scores for the Pain Disability Questionnaire and Tampa Scale for Kinesiophobia were 74 (IQR 34–104.5, 150 high) and 40 (IQR 35–45, 68 high).

Conclusions
Evidence of provision of appropriate integrated and person-centred chronic pain care is lacking.
Associations Between Gastric Atrophy and Its Interaction With Poor Oral Health and the Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Region of China: A Population-Based Case-Control Study
Authors: Ekheden Isabella , Yang Xiaorong , Chen Hui , Chen Xingdong , Yuan Ziyu , Jin Li , Lu Ming , Ye Weimin 
Published: December 2019

Abstract
Previous findings concerning gastric atrophy as a potential risk factor for esophageal squamous cell carcinoma (ESCC) have been inconsistent. We aimed to test whether gastric atrophy and, further, its interaction with poor oral health elevated the risk of ESCC in a high-risk region of China. Our population-based case-control study in Taixing, China (2010–2014), recruited cases from local hospitals and the local cancer registry. Controls were selected randomly from the local population registry. Ultimately, 1,210 cases and 1,978 controls answered questionnaires and provided blood samples for assay of pepsinogens. Unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Gastric atrophy (defined as a serum level of pepsinogen I of &lt;55 μg/L) was associated with an increased risk for ESCC (odds ratio = 1.61; 95% confidence interval: 1.33, 1.96), even after full adjustment for potential confounding factors. In addition, suggestion of an additive interaction between gastric atrophy and poor oral health was observed (relative excess risk due to interaction = 1.28, 95% confidence interval: 0.39, 2.18). We conclude that gastric atrophy appears to be a risk factor for ESCC in a high-risk region of China, and there is a suggested additive interaction with poor oral health that increases this risk even further.
Association of Childbearing With a Short-Term Reduced Risk of Crohn Disease in Mothers
Authors: Kravdal Øystein , Magnus Per , Moum Bjørn , Høivik Marte Lie 
Published: December 2019

Abstract
Our aim in this study was to analyze the importance of childbearing for risk of inflammatory bowel disease. Using data from the Norwegian Population Register and the Norwegian Patient Register, we fitted discrete-time hazard models for diagnosis of Crohn disease (CD) or ulcerative colitis (UC) among men and women aged 18–81 years in 2011–2016. Year and various sociodemographic factors were controlled for. The data included 4,304 CD cases and 8,866 UC cases. Women whose youngest child was ≤4 years of age had lower CD risk the following year than childless women (odds ratio (OR) = 0.73, 95% confidence interval (CI): 0.62, 0.86). There was no such reduction in CD risk among fathers. Men whose youngest child was aged ≥20 years had higher risks of CD (OR = 1.22, 95% CI: 1.01, 1.49) and UC (OR = 1.15, 95% CI: 1.02, 1.30) than childless men. UC risk was also increased among men whose youngest child was aged ≤4 years (OR = 1.14, 95% CI: 1.02, 1.27). The short-term reduction in women’s CD risk after a birth may reflect biological effects of pregnancy. Alternatively, it may reflect residual confounding or lifestyle effects of parenthood that are of special relevance for CD in women. In particular, differences in use of oral contraceptives (which it was not possible to control for) may have contributed to the observed pattern.
Liability for Third-Party Harm When Harm-Inflicting Consumers Are Present Biased
Authors: Friehe Tim , Rößler Christoph , Dong Xiaoge 
Published: December 2019

Abstract
This article analyzes the workings of liability when harm-inflicting consumers are present biased and both product safety and consumer care influence expected harm. We show that present bias introduces a rationale for shifting some losses onto the manufacturer, in stark contrast with the baseline scenario in which strict consumer liability induces socially optimal product safety and precaution levels. In addition, we establish that strict liability with contributory negligence may induce socially optimal product safety and precaution choices.
Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific
Authors: Yang Danqing , Günter Robert , Qi Guanxiao , Radnikow Gabriele , Feldmeyer Dirk 
Published: December 2019

Abstract
Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, for example, wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M 4 and M1 mAChRs, respectively. At ~ 1 mM, ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs without affecting CC PCs. Miniature EPSC frequency in CC PCs was decreased by ACh but increased in CT PCs. In synaptic connections with a presynaptic CC PC, glutamate release was suppressed via M4 mAChR activation but enhanced by nAChRs via α4β2 nAChRs when the presynaptic neuron was a CT PC. Thus, in L6A, the interaction of mAChRs and nAChRs results in an altered excitability and synaptic release, effectively strengthening CT output while weakening CC synaptic signaling.
Oscillatory Mechanisms of Successful Memory Formation in Younger and Older Adults Are Related to Structural Integrity
Authors: Sander Myriam C , Fandakova Yana , Grandy Thomas H , Shing Yee Lee , Werkle-Bergner Markus 
Published: December 2019

Abstract
We studied oscillatory mechanisms of memory formation in 48 younger and 51 older adults in an intentional associative memory task with cued recall. While older adults showed lower memory performance than young adults, we found subsequent memory effects (SME) in alpha/beta and theta frequency bands in both age groups. Using logistic mixed effects models, we investigated whether interindividual differences in structural integrity of key memory regions could account for interindividual differences in the strength of the SME. Structural integrity of inferior frontal gyrus (IFG) and hippocampus was reduced in older adults. SME in the alpha/beta band were modulated by the cortical thickness of IFG, in line with its hypothesized role for deep semantic elaboration. Importantly, this structure–function relationship did not differ by age group. However, older adults were more frequently represented among the participants with low cortical thickness and consequently weaker SME in the alpha band. Thus, our results suggest that differences in the structural integrity of the IFG contribute not only to interindividual, but also to age differences in memory formation.
Ideational Differences, Perception Gaps, and the Emerging Sino–US Rivalry
Authors: Chengqiu Wu 
Published: December 2019

Abstract
Bilateral relations between China and the United States have evolved over the past two decades from the ‘same bed, different dreams’ of the 1990s when, despite different interests and perceptions, globalisation and multilateralism drew them closer, to the potential ‘different beds, same nightmare’ scenario where their economies draw further apart and their governments are locked in hegemonic rivalry. Drawing on Wendtian constructivism and cognitive psychology, this article proposes a systematic and dynamic theoretical framework and a review of the evolution of Sino–US relations to explain how and why the above changes happened. We subdivide Sino–US relations since the early 1990s into five periods that describe the United States’ China strategy in four aspects and China’s US strategy in three aspects. Our findings are that the United States’ China strategy has changed dramatically while China’s US strategy has remained relatively stable, and that Sino–US relations from the early 1990s to mid-2010 were characterised by cooperation borne of strategic compatibility, whereas those ensuing were characterised by competition due to strategic incompatibility. We argue that rivalry between the two countries stems from their fundamentally different ideas, namely, Chinese statist nationalism and American liberal hegemony, and that gaps in perception have exacerbated the differences. Simply put, their ‘different dreams’ have led to the ‘same nightmare’.
Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors
Authors: Garrido-Trigo Alba , Salas Azucena 
Published: December 2019

AbstractCytokines can trigger multiple signalling pathways, including Janus tyrosine kinases [JAK] and signal transducers and activators of transcription [STATS] pathways. JAKs are cytoplasmic proteins that, following the binding of cytokines to their receptors, transduce the signal by phosphorylating STAT proteins which enter the nuclei and rapidly target gene promoters to regulate gene transcription. Due to the critical involvement of JAK proteins in mediating innate and adaptive immune responses, these family of kinases have become desirable pharmacological targets in inflammatory diseases, including ulcerative colitis and Crohn’s disease. In this review we provide an overview of the main cytokines that signal through the JAK/STAT pathway and the available in vivo evidence on mutant or deleted JAK proteins, and discuss the implications of pharmacologically targeting this kinase family in the context of inflammatory diseases.
Novel rhizobia exhibit superior nodulation and biological nitrogen fixation even under high nitrate concentrations
Authors: Nguyen Hien P , Miwa Hiroki , Obirih-Opareh Jennifer , Suzaki Takuya , Yasuda Michiko , Okazaki Shin 
Published: December 2019

ABSTRACTLegume–rhizobium symbiosis leads to the formation of nitrogen-fixing root nodules. However, externally applied chemical nitrogen fertilizers (nitrate and ammonia) strongly inhibit nodule formation and nitrogen fixation. Here, we isolated several rhizobial strains exhibiting a superior nodulation and nitrogen fixation with soybean at high nitrate concentrations. The nodulation of soybean symbiont Bradyrhizobium diazoefficiens USDA110 was significantly inhibited at 12.5 mM nitrate; however, three isolates (NKS4, NKM2 and NKTG2) were capable of forming nitrogen-fixing nodules, even at 20 mM nitrate. These isolates exhibited higher nodulation competitiveness and induced larger nodules with higher nitrogen-fixation activity than USDA110 at 5 mM nitrate. Furthermore, these isolates induced more nodules than USDA110 even in nitrate-free conditions. These isolates had a distant lineage within the Bradyrhizobium genus; though they were relatively phylogenetically close to Bradyrhizobium japonicum, their morphological and growth characteristics were significantly different. Notably, in the presence of nitrate, expression of the soybean symbiosis-related genes (GmENOD40 and GmNIN) was significantly higher and expression of GmNIC1 that is involved in nitrate-dependent nodulation inhibition was lower in the roots inoculated with these isolates in contrast with inoculation of USDA110. These novel rhizobia serve as promising inoculants for soybeans cultivated in diverse agroecosystems, particularly on nitrate-applied soils.
Arbuscular mycorrhiza has little influence on N2O potential emissions compared to plant diversity in experimental plant communities
Authors: Okiobe Simon T , Rillig Matthias C , Mola Magkdi , Augustin Jürgen , Parolly Gerald , Veresoglou Stavros D 
Published: December 2019

ABSTRACT
Denitrification is an ecosystem process linked to ongoing climate change, because it releases nitrous oxide (N2O) into the atmosphere. To date, the literature covers mostly how aboveground (i.e. plant community structure) and belowground (i.e. plant-associated soil microbes) biota separately influence denitrification in isolation of each other. We here present a mesocosm experiment where we combine a manipulation of belowground biota (i.e. addition of Rhizophagus irregularis propagules to the indigenous mycorrhizal community) with a realized gradient in plant diversity. We used a seed mix containing plant species representative of mesophytic European grasslands and by stochastic differences in species establishment across the sixteen replicates per treatment level a spontaneously established gradient in plant diversity. We address mycorrhizal-induced and plant-diversity mediated changes on denitrification potential parameters and how these differ from the existing literature that studies them independently of each other. We show that unlike denitrification potential, N2O potential emissions do not change with mycorrhiza and depend instead on realized plant diversity. By linking mycorrhizal ecology to an N-cycling process, we present a comprehensive assessment of terrestrial denitrification dynamics when diverse plants co-occur.
Integrating DNA sequencing and transcriptomic data for association analyses of low-frequency variants and lipid traits
Authors: Yang Tianzhong , Wu Chong , Wei Peng , Pan Wei 
Published: December 2019

AbstractTranscriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and transcriptomic data to showcase their improved statistical power of identifying gene–trait associations while, importantly, offering further biological insights. TWAS have thus far focused on common variants as available from GWAS. Compared with common variants, the findings for or even applications to low-frequency variants are limited and their underlying role in regulating gene expression is less clear. To fill this gap, we extend TWAS to integrating whole genome sequencing data with transcriptomic data for low-frequency variants. Using the data from the Framingham Heart Study, we demonstrate that low-frequency variants play an important and universal role in predicting gene expression, which is not completely due to linkage disequilibrium with the nearby common variants. By including low-frequency variants, in addition to common variants, we increase the predictivity of gene expression for 79% of the examined genes. Incorporating this piece of functional genomic information, we perform association testing for five lipid traits in two UK10K whole genome sequencing cohorts, hypothesizing that cis-expression quantitative trait loci, including low-frequency variants, are more likely to be trait-associated. We discover that two genes, LDLR and TTC22, are genome-wide significantly associated with low-density lipoprotein cholesterol based on 3203 subjects and that the association signals are largely independent of common variants. We further demonstrate that a joint analysis of both common and low-frequency variants identifies association signals that would be missed by testing on either common variants or low-frequency variants alone.
Primary health care patient satisfaction: Explanatory factors and geographic characteristics
Authors: Ferreira Pedro L , Raposo Vitor , Tavares Aida Isabel 
Published: December 2019

Abstract

Objective
To determine the factors that explain the levels of patient satisfaction and the role of geographical characteristics.

Design
Questionnaires to patients of Primary Health Care (PHC) units in Portugal Mainland distributed to each unit according to their size; codes were distributed to guarantee single responses; the questionnaire was anonymous and confidential.

Setting
Primary Health Care units in Portugal Mainland.

Participants
Primary health care patients.

Intervention(s)
None.

Main Outcome Measure(s)
Overall patient satisfaction.

Results
The main results indicate that the most significant dimension explaining overall patient satisfaction index is the satisfaction regarding general practitioner (GP) care, and the two other most significant explanatory variables of satisfaction are to be enrolled in a GP list and education. The bigger is the size of a PHC unit the lower is satisfaction. In rural areas, the level of satisfaction is higher than in urban areas. Comparing to the Lisbon metropolitan area, all other regions show a higher satisfaction in access dimension.

Conclusions
These results contribute to the creation of strategic information relevant to the evaluation of the various models of Primary Health Care, to the commissioning and definition of health policies.
Genetic Variation Among Geographically Disparate Isolates of Aster Yellows Phytoplasma in the Contiguous United States
Authors: Clements Justin , Garcia Marjorie , Bradford Benjamin , Crubaugh Linda , Piper Shannon , Duerr Emily , Zwolinska Agnieszka , Hogenhout Saskia , Groves Russell L 
Published: December 2019

Abstract
Aster Yellows phytoplasma (AYp; Candidatus Phytoplasma asteris) is associated with diseases of herbaceous plants, including ornamentals and important commercial vegetable and grain crops. The aster leafhopper (ALH; Macrosteles quadrilineatus Forbes) is the predominant vector of these bacteria, though other leafhopper species can acquire and transmit AYp. Potentially inoculative leafhoppers are reported to overwinter in the southern United States and migrate to northern latitudes in the spring. Examining the genetic similarities and differences in AYp associated with southern and northern populations of ALH may provide insight into the role that migrating ALH play in AYp disease development. To investigate similarities among geographically distinct populations of ALH and characterize the variation in AYp associated within these populations, we identified genetic variations in subgroup designation and the relative proportions of secreted AY-WB proteins from field-collected populations of AYp isolated from ALH from select locations in the southern (Arkansas, Kansas, Oklahoma, and Texas) and the northern United States (Wisconsin) in 2016, 2017, and 2018. Isolated phytoplasma were tested for variation of AYp genotypes, numbers of potentially inoculative (AYp-positive) ALH, and presence of specific AYp virulence (effector) genes. Geographically distinct populations of ALH collected in northern and southern regions were similar in CO1 genotype but carried different proportions of AYp genotypes. While similar AYp strains were detected in geographically distinct locations, the proportion of each genotype varied over time.