bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left Ventricular F Ractional Shortening as a N Ovel Predictor of Clinical Outcomes in Patients With Coronary Artery Disease After Undergoing PCI: A Retrospective Cohort Study
Authors: Guo Qian-Qian , Tang Jun-Nan , Yang Xu-Ming , Zhang Jian-Chao , Cheng Meng-Die , Song Feng-Hua , Liu Zhi-Yu , Wang Kai , Jiang Li-Zhu , Fan Lei , Yue Xiao-Ting , Bai Yan , Dai Xin-Ya , Zhang Zeng-Lei , Zheng Ru-Jie , Zheng Ying-Ying , Zhang Jin-Ying 
Published: August 2020

Abstract
Background: Even though great advances have been made in the treatment of coronary artery disease (CAD) owing to coronary revascularization and modern antiremodeling therapy, it remains the major cause of cardiac morbidity and mortality worldwide. Risk stratification in CAD patients is primarily based on left ventricular ejection fraction (LVEF), risk scores, and some serum markers. The value of baseline Left ventricular fractional shortening (LVFS) level in predicting the clinical outcomes has not yet been determined.Methods: In this retrospective cohort study, a total of 3561 patients were enrolled in Clinical Outcomes and Risk Factors of Patients with CAD after percutaneous coronary intervention (PCI), from January 2013 to December 2017. After excluding patients without echocardiography data, we finally enrolled 2787 patients. These patients were divided into two groups according to LVFS value. The lower group (LVFS <31%, n=741), the higher group (LVFS≥31%, n=2046). The average follow-up time were 37.59±22.24 months.Results: We found that there were significant differences between the two groups in the incidence of all-cause mortality (ACM) (P<0.001), cardiac mortality (CM) (P<0.001), major adverse cardiovascular events (MACEs) (P<0.05) and major adverse cardiovascular and cerebrovascular events (MACCEs) (P<0.05). Multivariate Cox regression analyses showed that LVFS was an independent predictor for ACM (hazard ratio [HR]:0.473 [95% confidence interval [CI]:0.290-0.772],P=0.003), CM (HR: 0.393 [95% CI:0.213-0.725],P=0.003) in acute coronary syndrome (ACS) patients but that it was an independent predictor for only the incidence of CM (HR: 0.153 [95% CI:0.046-0.504],P=0.002) in stable CAD patients.Conclusion This study indicates that baseline LVFS is an independent and novel predictor of adverse long-term outcomes in CAD patients who underwent PCI.Trial registration:Chinese Clinical Trial Registry. ChiCTR-ORC-16010153. Registered 24 November 2018.http://www.chictr.org.cn/index.aspx
Single-Nucleotide Nr3C1 Gene Polymorphisms Affect Glucocorticosteroid Treatment Efficacy In Patients With Pemphigus Vulgaris
Authors: Thanh Le Thai Van , Quan Nguyen Duy , Dang Tran Ngoc , Pham Duy Le 
Published: August 2020

Abstract
Background

in recent years, the effectiveness of glucocorticosteroid (GC) treatment has become a central issue when managing patients with pemphigus vulgaris (PV). Polymorphisms in the gene encoding the nuclear receptor subfamily 3, group C, member 1 (NR3C1) protein (the GC receptor) may explain the observed variations in treatment efficacy. We aim to evaluate the effects of 10 SNPs (rs 17209237, rs11745958, rs7701443, rs33388, rs41423247, rs6189, rs6190, rs6195, rs6196, and rs6198) in Vietnamese PV patients.
Methods

we studied 10 sites in the NR3C1 gene (selected using published data) and sought correlations between single nucleotide polymorphisms (SNPs) in these regions and the clinical responses to GCs in 15 PV patients. Whole blood samples from all patients were collected in tubes containing ethylenediamine tetra-acetic acid (EDTA) and were genotyped using TaqMan SNP Genotyping assay.
Results

Of the 10 sites in the NR3C1 gene, SNPs were detected in 6 (rs17209237, rs11745958, rs7701443, rs41423247, rs33388, and rs6196); the genotypes rs17209237 AA, rs11745958 CC, and rs6196 AG may be associated with a need for a lower total GC dose; rs17209237 AA and rs6196 AG with shorter times to commencement of tapering; and rs17209237 AA and rs11745958 CC with shorter times to attainment of 50 and 25% Pemphigus Disease Activity Index scores.
Conclusions

NR3C1 gene variations may predict GC efficacy in PV patients. However, larger, randomized controlled trials are required.
Severe Anemia in Patients with Propionic Acidemia is Associated with Low Plasma Levels of Valine, Isoleucine and Methionine
Authors: Stanescu Sinziana , Belanger-Quintana Amaya , Quintero Victor , Maldonado Maria Soledad , Arrieta Francisco , Alcaide Patricia , Martínez-Pardo Mercedes 
Published: August 2020

Abstract
Background. Propionic acidemia (AP), an inborn error of metabolism, is caused by a deficiency in propionyl-CoA carboxylase. Patients have to follow a diet restricted in the propiogenic amino acids isoleucine (Iso), valine (Val), methionine (Met) and threonine (Thr); proper adherence can prevent and treat acute decompensation and increase life expectancy. However, chronic complications occur in several organs even though metabolic control may be largely maintained. Bone marrow aplasia and cytopenia are among the more common. Materials and methods. In this retrospective study, data for patients with PA being monitored at the Hospital Ramón y Cajal (Madrid, Spain) (n=10) were examined to statistically detect relationships between hematological complications outside of metabolic decompensation episodes, and plasma amino acids provided by the diet, urinary organic acids and plasma odd-chain fatty acids. High ferritin levels were deemed to indicate that a patient had received repeated transfusions for severe anemia since data on hemoglobin levels at the moment of transfusion were not always passed on by the attending centers. Results. Three patients had severe, persistent anemia that required repeated blood transfusions leading to high ferritin levels. Their low plasma Val, Ile and Met suggested that their anemia had a nutritional component. Conclusion. The present results suggest that severe anemia in patients with PA is associated with low plasma levels of Val, Ile and Met.
Failure of endoscopic management of ureteral strictures is due to ureteroscopic lithotripsy as a cause and longer length of stricture
Authors: Sugino Teruaki , Taguchi Kazumi , Hamamoto Shuzo , Okada Tomoki , Isogai Masahiko , Tanaka Yutaro , Unno Rei , Fujii Yasuhiro , Hamakawa Takashi , Ando Ryosuke , Okada Atsushi , Yasui Takahiro 
Published: August 2020

Abstract
Background

Ureteroscopic lithotripsy is a common treatment for middle and lower ureteral stones. Although effective and minimally invasive, this technique might cause significant complications, including postoperative ureteral strictures, which occur in 1–4% of patients after ordinary ureteroscopic lithotripsy and in 7.8–24% when lithotripsy is performed for impacted stones. The main purpose of the management of ureteral strictures is to improve hydronephrosis and protect renal function. However, factors that influence the success rate of the endoscopic management of US (e.g., the cause and length of stricture, the duration of hydronephrosis, surgical management technique, and the number of placed ureteral stents) are controversial. The aim of this study was to investigate factors determining the outcomes of endoscopic management for stone-related ureteral stricture.
Methods

This multi-center case series study was performed at one of the highest-volume centers and the affiliated institutions in Japan. Data of patients who underwent endoscopic surgery for ureteral stricture from January 2016 to March 2019 were retrospectively analyzed. Laser incision and/or balloon dilation were performed for management; single or double stents were placed at the end of the surgery. Treatment success was defined as improvement in hydronephrosis status.
Results

Nineteen patients were treated for stone-related ureteral stricture. Hydronephrosis successfully improved in 12 patients (63.2%). All seven patients with failed endoscopic management had ureteroscopic lithotripsy-related stricture, whereas 3/12 (25.0%) and 7/12 (58.3%) patients with ureteroscopic lithotripsy-related stricture and impacted stone-related stricture, respectively, underwent successful endoscopic treatment (P = 0.004). Stricture length > 15 mm was observed in five patients (71.4%) with failed management, two patients (16.6%) with successful management (P = 0.046), 7/10 patients (70.0%) with ureteroscopic lithotripsy-related stricture, and 1/7 patients (14.3%) with impacted stone-related stricture (P = 0.049). Among patients with ureteroscopic lithotripsy-related stricture and impacted stone-related stricture, both laser incision and balloon dilation were performed in 5/10 (50.0%) and 2/7 (28.6%) patients (P = 0.874) while double stents were placed in 5/10 (50.0%) and 5/7 (57.1%) patients (P = 0.874), respectively.
Conclusions

Ureteroscopic lithotripsy as a cause and stricture length > 15 mm could strongly affect the success rate of endoscopic management of ureteral stricture. In such cases, reconstructive management should be considered in the early stages.
Frequency Tracking Of A Prototype Elliptical RF Cavity
Authors: DAS RAJDIP 
Published: August 2020

Abstract
Remarkable development with the use of microwave cavity has occurred during the last two to three decades, particularly in portable correspondence, TV transmission, modern/local applications, satellite correspondence, telemetry, RADAR/navigational guides, and so forth. This quick improvement inside the microwave which of computerized advances has synergized, bringing about further quickened rate. The paper reports primarily on the frequency tracking system probably be coupled with radio frequency (RF) cavity. For the creating and testing of the tracking system, we have used phase detectors and loop filters throughout. The quality of the tracking system and thus the underlying scanning results were seen to help the realistic tests.
Adjuvant Treatment Approach in Primary Apocrine Adenocarcinoma Presenting With Axillary Mass: A Case Report
Authors: Bulut Gulcan , Senyurek Sukran , Eren Remziye 
Published: August 2020

Abstract
Background: Primary apocrine sweat gland adenocarcinoma is a very rare tumor. Apocrine carcinoma is a high incidence of local recurrence and lymph node metastasis. When the location of the tumor is axilla, it should be differentiated from occult breast cancer. Surgery is the first step in primary apocrine cancer treatment. However, there is no clear consensus about adjuvant part of treatment. In this case, we presented a 60-year old female patient with primary apocrine sweat gland carcinoma of the axilla. To our knowledge, this is the first case in the literature to use combined adjuvant radiation therapy and anti-estrogen therapy.Case presentation: A 60-year old female patient presented with a slowly growing mass in the right axilla. The patient was examined by a surgeon and there was suspected to be metastasis from breast cancer diagnosed in September 2017. Axillary localized apocrine carcinoma was differentiated from occult breast cancer by pathological findings. For this reason, the patient was operated only an axillary dissection operation. Operated patient with axillary apocrine carcinoma was treated with radiotherapy. As a result of pathological evaluation of the tumor, tamoxifen was added to the treatment when the hormone receptor was positive.Conclusions: The pathological features must be evaluated in detail for targeted treatment, which should be ap-plied with a multidisciplinary approach. Based on this case presentation and literature, adjuvant radiotherapy can be recommended to reduce the risk of local recurrence and hormone-therapy to reduce distant recurrence in patients with hormone-receptor positive primary apocrine carcinoma.
Neutrophil-lymphocyte Ratio as a Predictor of Delirium in Older Hospitalized Patients: A Prospective Cohort Study
Authors: Zhao Yanli , Yue Jirong , Lin Taiping , Peng Xuchao , Xie Dongmei , Gao Langli , Shu Xiaoyu , Wu Chenkai 
Published: August 2020

Abstract
Background: Delirium is a common neuropsychiatric syndrome in older hospitalized patients. Previous studies have suggested that inflammation and oxidative stress contribute to the pathophysiology of delirium. However, it remains unclear whether neutrophil-lymphocyte ratio (NLR), an indicator of systematic inflammation, is associated with delirium. This study aimed to investigate the value of NLR as a predictor of delirium among older hospitalized patients.Methods: We conducted a prospective study of 740 hospitalized patients aged 70 years at the West China Hospital of Sichuan University. Neutrophil and lymphocyte counts were collected within 24 hours after hospital admission. Delirium was assessed on admission and every 48 hours thereafter. We used the Receiver operating characteristic analysis to assess the ability of the NLR for predicting delirium. The optimal cut-point value of the NLR was determined based on the highest Youden index (sensitivity + specificity - 1). Patients were categorized according to the cut-point value and quartiles of NLR, respectively. We then used logistic regression to identify the unadjusted and adjusted associations between NLR as a categorical variable and delirium. Results: The optimal cut-point value of NLR for predicting delirium was 3.626 (sensitivity: 75.2%; specificity: 63.4%; Youden index: 0.386). The incidence of delirium was significantly higher in patients with NLR >3.626 than NLR ≤3.626 (24.5% vs 5.8%; P<0.001). Significantly fewer patients in the first quartile of NLR experienced delirium than in the 3rd (4.3% vs 20.0%; P<0.001) and 4th quartiles of NLR (4.3% vs 24.9%; P<0.001). Multivariable logistic regression analysis showed that NLR was independently associated with delirium.Conclusions: NLR is a simple and practical marker that can predict the development of delirium in older hospitalized patients.
Comparison of somatic STAT3 and STAT5b gene mutations between Felty's syndrome and T-cell large granular lymphocytic leukemia with rheumatoid arthritis
Authors: Gorodetskiy Vadim R. , Sidorova Yulia V. , Kupryshina Natalia A. , Vasilyev Vladimir I. , Probatova Natalya A. , Ryzhikova Natalya V. , Sudarikov Andrey B. 
Published: August 2020

Abstract
Objectives Approximately 15% of patients with T-cell large granular lymphocytic leukemia (T-LGLL) have rheumatoid arthritis (RA). RA-associated T-LGLL with low large granular lymphocyte counts (aleukemic presentation) and Felty's syndrome (FS) have indistinguishable clinical presentations. These disorders are distinguished by T-cell clonality which is observed in T-LGLL but not in FS. Activating somatic mutations in the signal transducer and activator of transcription 3 (STAT3) and 5 (STAT5b) genes are involved in T-LGLL pathogenesis; however, the prevalence of these mutations in FS is unknown.Methods Based on the rearrangements of T-cell receptor (TCR) gamma and beta genes according to the BIOMED-2 protocol, we examined T-cell clonality in 81 patients with RA and unexplained neutropenia. We stratified these patients by the presence or absence of T-cell clonality, respectively, into 2 groups: RA-associated T-LGLL (56 patients) and FS (25 patients). Allele-specific TaqMan Real-Time polymerase chain reaction assay was employed to detect point somatic mutations in STAT3 and STAT5b genes in each group.Results Mutations of the STAT3 gene were detected in none of the 24 cases of FS and in 22 of 56 cases of RA-associated T-LGLL (39%) (p < 0.001). No mutation of the STAT5b gene was detected in any of the patients in each group.Conclusions Although further data are needed, our results suggest that activating somatic mutations in STAT3 and STAT5b genes are not involved in the pathogenesis of FS.
Physician distribution across China’s cities: Regional variations
Authors: Yu Xuexin , Zhang Wei , Liang Jersey 
Published: August 2020

Abstract
Background Distribution of physicians is a key component of access to health care. Although there is extensive research on urban-rural disparities in physician distribution, limited attention has been directed to the heterogeneity across urban areas.This research depicts variations in physician density across over 600 cities in the context of China’s rapid urbanization. Methods Data came from National Census Surveys and China statistical yearbooks, 2000-2003, and 2010-2013. Cities were characterized in terms of not only administrative level but also geographic regions and urban agglomerations. We analyzed variations in physician supply by applying generalized estimating equations with an ordinal logistic linking function. Results Although overall physician density increased between 2003 and 2013, with population and socioeconomic attributes adjusted, physician density actually declined in urban China. On average, urban districts had a higher physician density than county-level cities, but there were regional variations. Cities in urban agglomerations and those outsides did not differ in physician density.Conclusion Despite the improved inequality between 2003 and 2013, the growth in physician density did not appear to be commensurate with the changes in population health demand. Assessment in physician distribution needs to take into account heterogeneity in population and socioeconomic characteristics.
Comprehensive Analysis of Potential Genes in Brain Metastasis of Breast Cancer
Authors: Huang Kanghua , Guo Qiuyi , Luo Xueying , Li Feng , Gao Rui , Zhou Zihan , He Jinsong 
Published: August 2020

Abstract
Background Patients with brain metastasis of breast cancer have low quality of life, are prone to bad emotions such as anxiety and depression, and have poor prognosis. It is particularly important to find therapeutic targets for this type of patients. Methods The differential genes between breast cancer patients with brain metastasis and simple breast cancer were screened by GSE125989 of GEO database, and the hub gene affecting the prognosis of breast cancer patients were identified by bc-GenExMiner database, and then the hub gene were analyzed comprehensively by STRING database and DAVIA database.Results We found that OPA1 is a potential indicator for predicting the prognosis of Asian patients with breast cancer with brain metastasis.OPA1 is involved in affecting the composition and function of mitochondria, affecting energy supply, and is also related to the FOXO signal pathway. Conclusions The effect of OPA1 on mitochondrial energy supply and its participation in FOXO signaling pathway may lead to brain metastasis of cancer. OPA1 is a potential therapeutic target for the treatment of brain metastasis of breast cancer, and further research is needed.
To What Extent Does Human Capital Development Impact Economic Growth? Empirical Evidence From Nigeria.
Authors: Abubakar Attahir Babaji , Bala Ahmad Sani , Musa Abdullahi Aliyu 
Published: August 2020

Abstract
This study examined the effect of human capital development on the economic growth of Nigeria. In achieving this, the human capital variables of education and health care were included in the study. The study employed the Autoregressuve and Distributive Lag (ARDL) model to annual series covering the period 1983 to 2018 for analysis. The findings of the study revealed the presence of a long-run association among the stua﻿dy variables. Further, it was discovered that in both the short and long run, both components of human capital development produce a positive effect on economic growth, although the effect of education appeared to be larger. The study emphasized the need for policymakers to enhance both access to and quality of health care and education with a view to stimulating the economic growth of Nigeria.
The Association Between Deficiency of Nutrient Intake on Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study
Authors: Sajjadi Seyedeh Forough , Mirzababaei Atieh , Abdollahi Afsoun , Shiraseb Farideh , Mirzaei Khadijeh 
Published: August 2020

Abstract
Background: The double burden of malnutrition is an emerging public health concern nowadays which a correlation with Obesity. The aim of this study was to examine the relationship between resting metabolic rate (RMR) and dietary intake of zinc, vitamin C, and riboflavin based on Nutrient Adequacy Ratios (NAR) in overweight and obese women.Methods: We enrolled 293 overweight and obese women in this cross-sectional study. BMI, body fat mass, fat-free mass, insulin level were assessed. RMR was measured using indirect calorimetry. NAR was measured by calculating the ratio of daily individual intakes to the standard recommended amounts.Results: the RMR/FFM showed a significant association with riboflavin (β=1.59; 95% CI: 1.04-23.26, P=0.04) and zinc (β=0.78; 95% CI: 1.04-4.61, P=0.03) in the crude model. Moreover, differences in vitamin C and RMR/FFM was marginal significant (β=0.75; 95% CI: 0.95-4.77, P=0.06). After adjust for confounders the riboflavin association change to marginal significance (β=1.52; 95% CI: 0.91-23.04, P=0.06). After controlling for potential confounders, the associations change between zinc and RMR/FFM (β=0.66; 95% CI: 0.78-4.86, P=0.15) and between RMR/FFM and vitamin C (β=0.48; 95% CI: 0.66-3.96, P=0.28).Conclusion: Our study showed a significant association between dietary intake of zinc, riboflavin, and vitamin C and change in RMR/FFM in overweight and obese women.
Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults
Authors: Zhang Wenli , He Kun , Zhao Hao , Hu Xueqi , Yin Chunyu , Zhao Xiaoyan , Shi Songhe 
Published: August 2020

Abstract
Background: The relationship between obesity and prevalent hypertension in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with hypertension, and to assess the appropriate level of BMI and WC for hypertension. Methods: We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for hypertension. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for hypertension. Results: The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for hypertension were 1.084 (1.080-1.087) and 1.025 (1.024-1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with hypertension in both men and women (all P<0.001). The risk of hypertension increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of hypertension was significantly enhanced. Conclusion: These findings suggest increased hypertension prevalence in the elderly population with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of hypertension in older adults.