bluuebunny/crossref_metadata_2025_split huggingface dataset:
The weak decay $$B_c$$ to Z(3930) and X(4160) by Bethe–Salpeter method
Authors: Wang Zhi-Hui , Zhang Yi , Wang Tianhong , Jiang Yue , Wang Guo-Li 
Published: August 2020

AbstractConsideringZ(3930) andX(4160) as$$\chi _{c2}(2P)$$χc2(2P)and$$\chi _{c2}(3P)$$χc2(3P)states, the semileptonic and nonleptonic of$$B_c$$Bcdecays toZ(3930) andX(4160) are studied by the improved Bethe–Salpeter (B–S) Method. The form factors of decay are calculated through the overlap integrals of the meson wave functions in the whole accessible kinematical range. The influence of relativistic corrections are considered in the exclusive decays. Branching ratios of$$B_c$$Bcweak decays toZ(3930) andX(4160) are predicted. Some of the branching ratios are:$$Br(B_c^+\rightarrow Z(3930)e^+\nu _e)=(3.03^{+0.09}_{-0.16})\times 10^{-4}$$Br(Bc+→Z(3930)e+νe)=(3.03-0.16+0.09)×10-4and$$Br(B_c^+\rightarrow X(4160)e^+\nu _e)=(3.55^{+0.83}_{-0.35})\times 10^{-6}$$Br(Bc+→X(4160)e+νe)=(3.55-0.35+0.83)×10-6. These results may provide useful information to discoverZ(3930) andX(4160) and the necessary information for the phenomenological study of$$B_c$$Bcphysics.
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Authors: Brown Justin C. , Zhang Sui , Ligibel Jennifer A. , Irwin Melinda L. , Jones Lee W. , Campbell Nancy , Pollak Michael N. , Sorrentino Alexandra , Cartmel Brenda , Harrigan Maura , Tolaney Sara M. , Winer Eric P. , Ng Kimmie , Abrams Thomas A. , Sanft Tara , Douglas Pamela S. , Hu Frank B. , Fuchs Charles S. , Meyerhardt Jeffrey A. 
Published: August 2020

AbstractObservational studies report that physical activity and metformin are associated with improved clinical outcome in patients with cancer. Inflammation is one biological mechanism hypothesized to mediate these associations. In this phase II, multicenter, 2 × 2 factorial trial, 139 patients with breast and colorectal cancer who completed standard therapy were randomized to one of four treatment groups for 12 weeks: exercise alone, metformin alone, exercise and metformin, or control. Inflammation outcomes included high-sensitivity C-reactive protein (hs-CRP), soluble tumor necrosis factor alpha receptor two (sTNFαR2), and IL6. The primary modeling strategy evaluated the trial product estimand that was quantified using a generalized linear mixed model. Compared with control, exercise alone reduced hs-CRP [−30.2%; 95% confidence interval (CI), −50.3, −1.0] and IL6 (−30.9%; 95% CI, −47.3, −9.5) but did not change sTNFαR2 (1.0%; 95% CI, −10.4, 13.9). Compared with control, metformin alone did not change hs-CRP (−13.9%; 95% CI, −40.0, 23.4), sTNFαR2 (−10.4%; 95% CI, −21.3, 2.0), or IL6 (−22.9%; 95% CI, −42.3, 2.0). Compared with control, exercise and metformin reduced sTNFαR2 (−13.1%; 95% CI, −22.9, −1.0) and IL6 (−38.7%; 95% CI, −52.3, −18.9) but did not change hs-CRP (−20.5%; 95% CI, −44.0, 12.7). The combination of exercise and metformin was not synergistic for hs-CRP, sTNFαR2, or IL6. In survivors of breast and colorectal cancer with low baseline physical activity and without type 2 diabetes, exercise and metformin reduced measures of inflammation that are associated with cancer recurrence and mortality.
Factor VII Activating Protease Expression in Human Platelets and Accumulation in Symptomatic Carotid Plaque
Authors: Parahuleva Mariana S. , Worsch Michael , Euler Gerhild , Choukeir Maryana , Mardini Amar , Parviz Behnoush , Kanse Sandip M. , Portig Irene , Khayrutdinov Evgeny , Schieffer Bernhard , Markus Birgit 
Published: August 2020

Background
Factor VII activating protease (FSAP) is of interest as a marker for vascular inflammation and plaque destabilization. The aim of this study was to analyze the expression profile of FSAP in endarterectomy specimens that were taken from patients with asymptomatic and symptomatic carotid atherosclerotic plaques and to compare them with circulating FSAP levels.

Methods and Results
Plasma FSAP concentration, activity, and mRNA expression were measured in endarterectomy specimens and in monocytes and platelets. Plaque and plasma FSAP levels were higher in symptomatic patients (n=10) than in asymptomatic patients (n=14). Stronger FSAP immunostaining was observed in advanced symptomatic lesions, in intraplaque hemorrhage‐related structures, and in lipid‐rich areas within the necrotic core. FSAP was also colocalized with monocytes and macrophages (CD11b/CD68‐positive cells) and platelets (CD41‐positive cells) of the plaques. Moreover, human platelets expressed FSAP in vitro, at both the mRNA and protein levels. Expression is stimulated by thrombin receptor‐activating peptide and ADP and reduced by acetylsalicylic acid.

Conclusions
Plasma FSAP levels were significantly increased in patients with symptomatic carotid stenosis and thus may be involved in plaque development This plaque‐associated FSAP may be produced by platelets or macrophages or may be taken up from the circulation. To establish FSAP’s utility as a circulating or plaque biomarker in patients with symptomatic carotid atherosclerotic plaques, further studies are needed.
Laparoscopic-Assisted Abdominal Wall Pexy of Peritoneal Dialysis Catheter
Authors: Wei Wei , Fanous Medhat 
Published: August 2020

Background Peritoneal dialysis (PD) for rural patients with end-stage renal disease (ESRD) is convenient, efficient, and durable. However, patients with a history of previous abdominal surgeries or peritonitis are at an increased risk of PD malfunction. This case highlights the impact of securing the catheter to the abdominal wall laparoscopically to keep the PD catheter in an adhesion-free area to maintain patency and function in a patient with extensive intraperitoneal adhesions. Subject A 76-year-old white male was on PD which later was complicated with peritonitis and sepsis and subsequent catheter removal. A year later, the patient desired replacement of the PD catheter. Intraoperatively, diagnostic laparoscopy revealed significant intraperitoneal adhesions mainly located at the left side of the abdomen with the right side of the abdomen spared. The Tenckhoff PD catheter, which was straightened by a steel stylet, was inserted via a 5-mm trocar. The stylet was removed. The pig tail of the PD catheter was navigated away from the adhesion and directed to the right side of the abdomen for internal fixation. The catheter at 9 cm from the PD catheter cuff was attached to the right paramedian peritoneum. Results PD started 1 week after placement. The patient had excellent inflow and outflow for 14 months to date without complication or need for revision. Conclusion The laparoscopic pexy of the PD catheter to the abdominal wall to keep the catheter in an adhesion-free compartment is beneficial in selected patients. A future study with a larger number of patients is needed to further validate this strategy.
Information Type Influences Students’ Perceptions of Faculty Self-Disclosures
Authors: Hill Katherine Grace , Martischewsky Macy Jayne , Erickson Cynthia Ann 
Published: August 2020

Background: Faculty might disclose personal information in order to illustrate a concept related to course material. However, the impact of self-disclosing potentially personal information (e.g., medical or mental health) is unclear. Objective: The purpose of this study was to determine how students perceive professors who self-disclose personal information during lectures, given that some conditions may be viewed negatively. Method: Introductory psychology students ( N = 137) completed an online survey in which they rated female professors in vignettes describing course lectures. Each lecture was one of the following topics: bipolar disorder, opioid addiction, breast cancer, brain tumor, and animal learning (control). At the end of each vignette, the professor self-disclosed personal information related to that lecture. Results: Overall, students perceived professors who disclosed physical (breast cancer and brain tumor) conditions more positively compared to psychological (bipolar and opioid addiction) conditions. Highest approval ratings were given to the professor with breast cancer. Conclusion: Students’ perceptions of self-disclosure depended on the type of personal information, providing a springboard for future studies on this topic. Teaching Implications: Given the different levels of approval for each professor, we cannot make a blanket recommendation as to whether personal information should be shared in the classroom.
State anxiety and alcohol choice: Evidence from experimental and online observational studies
Authors: Dyer Maddy L , Board Alexander G , Hogarth Lee , Suddell Steph F , Heron Jon E , Hickman Matthew , Munafò Marcus R , Attwood Angela S 
Published: August 2020

Background: Experimental studies have investigated the effects of physical, psychological and pharmacological stressors (that induce state anxiety) on alcohol outcomes. However, no study has investigated the effects of state anxiety on alcohol outcomes, and the moderating role of drinking to cope (DTC) motives, using the 7.5% carbon dioxide (CO2) challenge. Aims: We aimed to investigate the relationships between state anxiety and alcohol-related outcomes (primarily alcohol choice). We also explored whether DTC motives moderated these relationships. Methods: We conducted two experiments using the 7.5% CO2 challenge (Studies 1 and 2) and an observational study (Study 3) ( ns = 42, 60 and 219, respectively), to triangulate findings. Results: In Study 1, experimentally induced state anxiety increased alcohol choice ( p < .001, ηp2 = .29). This finding was replicated in Study 2, but the effect was weaker ( p = .076, ηp2 = .06). Furthermore, DTC moderated the effect ( p = .013, ηp2 = .11). However, in Study 3 there was no clear evidence of an association between naturally occurring state anxiety and alcohol choice ( b = 0.05, p = .655), or a moderating role of DTC ( b = 0.01, p = .852). Conclusions: Experimentally induced, but not naturally occurring, state anxiety increases alcohol choice, although state anxiety levels were lower in the non-manipulated sample.
Lumbosacral spinal compression device with the use of a cushion back support in supine MRI
Authors: Sungkarat Witaya , Laothamatas Jiraporn , Worapruekjaru Ladawan , Hooncharoen Boonthida , Charoensuk Jarruwat , Chousangsuntorn Khaisang 
Published: August 2020

Background We hypothesized that axial-loaded magnetic resonance imaging (MRI), modified with the use of a cushion placed behind the lower back (i.e. BS-MRI method), would simulate the standing position more accurately than an axial-loaded MRI without a cushion back support (BS). Purpose To determine whether the BS-MRI method demonstrated similar morphologies on intervertebral disc (IVD), dural sac, and spinal curvature as those detected on 90° standing MRIs in individuals with suspected spinal stenosis. Material and Methods Twenty-five subjects underwent a BS-MRI, as well as axial-loaded and standing MRI studies. Outcome measures were four radiographic parameters of the lumbar spine: IVD height (DH); dural sac cross-sectional area (DCSA); and spinal curvature (i.e. lumbar lordosis [LL] and L1-L3-L5 angle [LA]). Results Major differences (>5%) between standing MRI and BS-MRI methods were observed in DCSA, DH, and LL. Major differences between standing and axial loaded MRIs were observed only in DCSA and LA. Although BS-MRIs demonstrate an image of the lumbar spine curvature (i.e. LA) which is closer to that when standing than axial-loaded MRIs, it is likely to overestimate both narrowing of dural sac and extent of LL. Conclusion Using a compression device with a BS to simulate weight-bearing on the lumbar spine is not recommended due to: (i) overestimation of the narrowing of the dural sac and extent of LL; and (ii) underestimation of loss of disc height. Supine axial-loading produced DCSA and DH which were strongly correlated with those detected with standing MRIs. Exceptions were that LL and LA were underestimated.
Superselective vesical artery embolization for intractable bladder hemorrhage related to pelvic malignancy
Authors: Kim Myung Sub , Hong Hyun Pyo , Kang Kyung A , Lee Young Rae , Joo Kwan Joong , Cho Young-Sam , Lee Yun-Gyoo 
Published: August 2020

Background Intractable bladder hemorrhage from pelvic malignancy can be potentially life-threatening and its management can be a challenging clinical problem. Purpose To evaluate safety, efficacy, and clinical outcome of superselective vesical artery embolization for the control of intractable bladder hemorrhage from pelvic malignancy. Material and Methods Between January 2010 and September 2018, 20 patients underwent superselective vesical artery embolization for intractable hematuria secondary to pelvic malignancy arising from or invading the bladder. Treatment details and clinical outcomes were obtained. Results There were 12 men and 8 women (mean age = 77 years). Bilateral embolization was performed in 10 patients and unilateral approach in 10 patients. Two patients died within four days after embolization due to underlying heart failure and systemic metastasis, respectively. The remaining 18 patients had a follow-up of >30 days. Bleeding was controlled after the first embolization in 17/18 patients and after a repeat embolization in the remaining one patient. The mean follow-up period of 18 patients was 10.6 months (range = 1–77 months). Late recurrent hemorrhage (≥ 30 days after embolization) was reported in 6 (33.3%) patients. Five of these six patients underwent repeat embolization. There were no major complications related to embolization. Conclusion Palliative superselective vesical artery embolization is a feasible, effective, and safe procedure to control intractable hematuria in patients with pelvic malignancy.
Consensus on Indications for Medial Cuneiform Opening Wedge (Cotton) Osteotomy in the Treatment of Progressive Collapsing Foot Deformity
Authors: Johnson Jeffrey E. , Sangeorzan Bruce J. , de Cesar Netto Cesar , Deland Jonathan T. , Ellis Scott J. , Hintermann Beat , Schon Lew C. , Thordarson David B. , Myerson Mark S. 
Published: August 2020

Recommendation: Forefoot varus is a physical and radiographic examination finding associated with the Progressive Collapsing Foot Deformity (PCFD). Varus position of the forefoot relative to the hindfoot is caused by medial midfoot collapse with apex plantar angulation of the medial column. Some surgeons use the term forefoot supination to describe this same deformity (see Introduction section with nomenclature). Correction of this deformity is important to restore the weightbearing tripod of the foot and help resist a recurrence of foot collapse. When the forefoot varus deformity is isolated to the medial metatarsal and medial cuneiform, correction is indicated with an opening wedge medial cuneiform (Cotton) osteotomy, typically with interposition of an allograft bone wedge from 5 to 11 mm in width at the base. When the forefoot varus is global, involving varus angulation of the entire forefoot and midfoot relative to the hindfoot, other procedures are needed to adequately correct the deformity. Level of Evidence: Level V, consensus, expert opinion.
Extended enzymatic stability of reconstituted lyophilized PEG-asparaginase in vials
Authors: Viña-Romero María M , Ramos Díaz Ruth , González García Jónathan , Nazco-Casariego Gloria , Díaz-Vera Jésica , Gutiérrez-Nicolás Fernando 
Published: August 2020

Asparaginase (ASNase) use as a tumour-inhibitor drug has changed completely the natural course of paediatric acute lymphoblastic leukaemia (ALL) in such a way that it represents a paradigm shift in ALL management. ASNase treatment emergence has significantly improved pathologic responses and increased survival rates of ALL patients. Although different ASNase forms are currently available, only the pegylated form (PEG-ASNase) is recommended by relevant clinic guides. PEG-ASNase form shows longer elimination half-life, reducing the number of administrations, along with an enhanced safety profile. In spite of all of these advantages, PEG-ASNase elevated cost limits enormously its use. PEG-ASNase is commercialised as a lyophilised powder which according to the manufacturer it is stable for 24 hours once reconstituted, as a result, the leftover is usually discarded. In this study we analysed the enzymatic stability of reconstituted PEG-ASNase after conservation in three different temperature conditions for 5 and 14 days, aiming to take advantage of the remaining leftover for the subsequent administration.  Our results have shown that PEG-ASNase is stable at 4°C, −20°C and −80°C for at least 14 days, retaining the 95% from the initial enzymatic activity in all three storage temperatures. According to our results, it is feasible to reuse the remaining content of PEG-ASNase vial after reconstitution, which means a 50% reduction of its cost for paediatric patient treatment and, consequently, removes the main barrier to use this drug in a wider population.
What Drives Risky Behavior in ADHD: Insensitivity to its Risk or Fascination with its Potential Benefits?
Authors: Shoham Rachel , Sonuga-Barke Edmund , Yaniv Ilan , Pollak Yehuda 
Published: August 2020

Objective: ADHD is linked to increased engagement in risky behavior (ERB). Recent work suggests that this link is mediated by the perceived benefits of the behaviors, but not by the perceived risks or the attitudes toward the risks. Here we examine this hypothesis, using the psychological risk-return and psychometric multidimensional measurement models. Method: Adults with or without ADHD completed questionnaires measuring the likelihood of different risky behaviors and the perceived risks and benefits ascribed to these behaviors. Participants’ ratings of 25 characteristics of various risky behaviors allowed us to derive two factors corresponding to perceived risk and perceived benefit of ERBs. Overall attitudes toward the perceived risks and benefits were extracted. Results: Perceived benefit mediated the link between ADHD and ERB, in both models. Attitudes toward the perceived risks mediated that link in the psychometric model only. Conclusion: Perceived benefit plays an important role in the link between ADHD and ERB.
Analyses of case-based surveillance data on malaria in pregnancy in Plateau State, Nigeria 2013–2017
Authors: Iyare Osarhiemen , Adebowale Ayo Stephen , Umeokonkwo Chukwuma David , Bamgboye Eniola Adetola , Gobir Abdullahi Abdulrazaq , Chikan Jiwok Joseph , Dahiru Tukur , Ajayi IkeOluwapo Oyeneye 
Published: August 2020

Background: Malaria in pregnancy accounts for 11% of maternal death in Nigeria. Plateau State has a low uptake of intermittent preventive treatment of malaria among women attending antenatal care. Objectives: This study examined the trend and made projections of reported cases of malaria in pregnancy in Plateau State. Methods: Data were extracted from the state disease surveillance system from January 2013 to December 2017. Reported cases of malaria in pregnancy within the 5 years under investigation were retrieved, merged and sorted by month of reporting and Local Government Area (LGA). Prevalence was calculated yearly for each LGA in Plateau State using Geographic Information System. Seasonal variation and projection were based on a multiplicative time series model. Results: In total, 62,997 cases of malaria in pregnancy were retrieved. Prevalence was 6.9% in 2013 and increased to 15.1% in 2017. Higher prevalence was observed in Wase, Kanam and Shendam LGAs. A cyclical trend with highest number of malaria in pregnancy cases was found within the third quarter of all the years. Within the 5 years, there was higher seasonal variation for quarters three (1.209834) and one (1.099711). The highest number of cases of malaria in pregnancy was likely to occur in the third quarter, while the least was found in the second quarter. The projected numbers of malaria in pregnancy cases are 20,121, 22,593 and 25,064 for year 2018, 2019 and 2020, respectively, and the highest number of cases occurs in the third quarter. Conclusion: Malaria in pregnancy follows an increasing trend in Plateau State, with greatest severity in the third quarter of the year. An effective intervention strategy against malaria among pregnant women is advocated.
MiR-4668 as a Novel Potential Biomarker for Eosinophilic Esophagitis
Authors: Bhardwaj Neeti , Sena Maria , Ghaffari Gisoo , Ishmael Faoud 
Published: August 2020

Introduction Eosinophilic esophagitis (EoE) is a clinico-pathological diagnosis characterized by esophageal dysfunction and eosinophilic infiltration of the esophagus. Demonstration of esophageal eosinophilia (more than 15 eosinophils/hpf) in biopsy specimen obtained by esophagogastroduodenoscopy (EGD) continues to be the gold standard for diagnosis and monitoring of response to therapy. There is a growing necessity for non-invasive biomarkers that can accurately diagnose this condition and assess response to therapy. While microRNAs (miRNA) are being investigated in allergic diseases, including EoE, not many studies have explored the role of salivary miRNAs in EoE. MiR-4668-5p is a particularly interesting candidate, as it is predicted to regulate TGF-beta signaling and has not previously been identified as a target in any allergy disease. We sought to further investigate the role of miR-4668 as a biomarker to characterize and monitor response to treatment with swallowed topical glucocorticoids. Methods After IRB approval, twenty-two adult patients with EoE were randomly enrolled to provide a saliva sample before and after 2 months of swallowed fluticasone therapy. Differences of miRNA expression before and after treatment were analyzed by paired T-test. A significance cutoff of <0.05 was used for all analyses. Results Expression of miR-4668 was higher in EoE vs. non-EoE subjects. The level of miR-4668 decreased in all subjects except one, with a mean fold change 0.49 ± 0.25. There was an association between miRNA expression and number of positive aeroallergens. The miR-4668 high group had a higher number of positive aeroallergen tests, while the miR-4668 low group had a greater number of subjects with drug allergies. Conclusions In this study, we identified that salivary miRNAs may serve as biomarkers to characterize EoE and response to topical corticosteroids. We specifically identified miR-4668 as a novel potential biomarker, which was not previously discovered as a target in EoE or any other allergic disease.