bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic and attitudinal antecedents of consumers' use and self-investment trajectories over time in an online TV content platform
Authors: Van der Linden Sam , Nimmegeers Stef , Geskens Kristof , Weijters Bert 
Published: May 2020

PurposeTo investigate if online TV content platforms create value for consumers (and increase use) by offering its users the possibility to self-invest in the service (by giving personal content preferences). We link demographic and attitudinal antecedents to the relation between self-investment and use.Design/methodology/approachData were collected together with a Belgian media company (N = 4,136). To test the effects a latent growth model was composed in a multigroup setting with gender as the grouping variable. The model is analyzed through structural equation modeling in Mplus 8.0.FindingsIn general, strong relations between self-investment and increased use were found, although the effect of self-investment on use was stronger for female consumers. Furthermore, we established strong hedonic effects on using and investing in the service. For men, easy to use platforms lead to less self-investment.Research limitations/implicationsOur findings are restricted to free services. Furthermore, attitudinal variables are antecedents of behaviors. However, a more complex interplay between behavioral and attitudinal variables is possible. Further research could use repeatedly measured attitudinal measures and link these to behaviors over time.Practical implicationsService developers could offer different platform interactions to different segments to create consumer value. Women seem more receptive for extra functionalities, such as the possibility to indicate preferences. Men mainly focus on the content offered.Originality/valueThis study focuses on a new form of media distribution, online TV content platforms, where we investigate two related behaviors of users over time (self-investment and use) instead of a general approximation of use. Multi-source data were used.
Determinants of agricultural insurance adoption: evidence from farmers in the state of São Paulo, Brazil
Authors: Carrer Marcelo José , Silveira Rodrigo Lanna Franco da , Vinholis Marcela de Mello Brandão , De Souza Filho Hildo Meirelles 
Published: May 2020

Purpose
The purpose of this study is to investigate the determinants of agricultural insurance adoption by farmers of the state of São Paulo, Brazil.

Design/methodology/approach
Primary data from the 2015/2016 crop season was collected from a sample of 175 farmers. Logit econometric models were applied to identify the variables that affect the probability of agricultural insurance adoption.

Findings
The empirical results show that the education level, access to technical assistance, use of management tools and farm size positively affect the probability of adopting agricultural insurance. In addition, farmers who produce soybean and/or corn are more likely to use insurance. On the other hand, the higher the farmers’ propensity to take risk the lower the likelihood of using insurance.

Research limitations/implications
The empirical analysis is based on cross-sectional data of a sample of 175 farmers of the state of São Paulo. The use of panel data with a larger sample of farmers, considering a period of years, could provide additional information.

Originality/value
To the best of the knowledge, this is the first empirical analysis about determinants of agricultural insurance adoption by Brazilian farmers, considering behavioral factors. The findings provide useful insights for policymakers in formulating risk management programs in the Brazilian agricultural markets. A better understanding about the determinants of insurance adoption is also relevant for private companies that sell insurance to farmers. Therefore, the paper may contribute with the diffusion of rural insurance as risk management tool in Brazilian agriculture.
Latitudinal cline of larval growth rate and its proximate mechanisms in a rhinoceros beetle
Authors: Kojima Wataru , Nakakura Tatsunori , Fukuda Ayumi , Lin Chung‐Ping , Harada Masahiro , Hashimoto Yuki , Kawachi Aika , Suhama Shiho , Yamamoto Ryo 
Published: May 2020

Abstract

Juvenile growth rate is a key life‐history trait with a major effect on various fitness components. Duration of the growing season changes with latitude, often resulting in latitudinal variations in growth rate. While many studies have shown a latitudinal cline of growth rate, most have used linear measurements of growth rate without considering the nonlinear nature of growth trajectories. Furthermore, elucidation of the proximate mechanisms causing increased growth rates would provide a fundamental understanding of the evolutionary process of the latitudinal cline of growth rates, which are largely unknown.

We used common garden experiments to examine the latitudinal variation of growth rate. We analysed the larval growth curve of 14 populations of the univoltine Japanese rhinoceros beetle Trypoxylus dichotomus (Coleoptera: Scarabaeidae) found along a 2,000‐km latitudinal gradient. To clarify the mechanisms responsible for the latitudinal cline of growth rate, we compared food consumption and growth efficiency (i.e. the capacity to convert food into biomass) using three populations at high, middle and low latitudes.

There was a strong positive correlation between growth rate and latitude and a strong negative correlation between age at the inflexion point of the growth curve and latitude, indicating that larvae from northern populations grew more rapidly and reached the inflexion point earlier than those from southern populations.

The food intake increased linearly towards higher latitude. The growth efficiency of larvae from middle latitude was greater than that of larvae from low latitude, but there was no difference in the growth efficiency between high‐ and middle‐latitude populations.

The increased growth rate at higher latitude is probably a local adaptation to complete development and growth during the short growth season. The rapid growth rate at higher latitudes could be explained by both the increased food consumption and the growth efficiency. However, the growth efficiency is probably maximized in the middle‐latitude population, suggesting that some physiological costs prevent further increase in growth efficiency at higher latitudes. This study provides compelling evidence for latitudinal cline of juvenile growth rate and disentangles the contributions of food intake and growth efficiency to the cline.

A free Plain Language Summary can be found within the Supporting Information of this article.
Global Regulations for a Digital Economy: Between New and Old Challenges
Authors: Beaumier Guillaume , Kalomeni Kevin , Campbell‐Verduyn Malcolm , Lenglet Marc , Natile Serena , Papin Marielle , Rodima‐Taylor Daivi , Silve Arthur , Zhang Falin 
Published: May 2020

AbstractDigital technologies are often described as posing unique challenges for public regulators worldwide. Their fast‐pace and technical nature are viewed as being incompatible with the relatively slow and territorially bounded public regulatory processes. In this paper, we argue that not all digital technologies pose the same challenges for public regulators. We more precisely maintain that the digital technologies’ label can be quite misleading as it actually represents a wide variety of technical artifacts. Based on two dimensions, the level of centralization and (im)material nature, we provide a typology of digital technologies that importantly highlights how different technical artifacts affect differently local, national, regional and global distributions of power. While some empower transnational businesses, others can notably reinforce states’ power. By emphasizing this, our typology contributes to ongoing discussions about the global regulation of a digital economy and helps us identify the various challenges that it might present for public regulators globally. At the same time, it allows us to reinforce previous claims that these are importantly, not all new and that they often require us to solve traditional cooperation problems.
Multimorbidity, health‐related quality of life and health service use among individuals with mental health problems: Urban‐rural differences in South Australia
Authors: Gonzalez‐Chica David Alejandro , Hoon Elizabeth , Stocks Nigel 
Published: May 2020

AbstractObjectiveTo investigate urban‐rural differences in the relationship between the coexistence of multiple physical health conditions, health‐related quality of life and health service use among individuals with mental health problems.DesignCross‐sectional.SettingPopulation‐based.ParticipantsRandom sample of 2977 South Australians aged 15+ years. Analyses restricted to 535 individuals self‐reporting a “current” mental health problem (anxiety, depression, another mental condition).ExposureNumber of physical health conditions (none, 1‐2, 3+ conditions) based on a list of 16 self‐reported chronic diseases.Main outcome measuresPhysical and mental health‐related quality of life, frequently visited a GP (3+ times), visited a mental health specialist, visited an emergency department, was hospitalised in the last 3 months.ResultsThe mean age of the participants was 57.3 ± 13.9 years (51.9% females) with 10.6% of them living in inner regional and 14.9% in outer/remote locations. Mental health problems had similar prevalence in major cities (15.4%; 95% confidence intervals [CI]: 13.5‐17.4), inner regional (19.3%; 95% CI: 14.8‐24.7) and outer/remote areas (16.8%; 95% CI: 14.4‐17.7). The remoteness of residence did not affect the relationship between the number of physical health conditions with health‐related quality of life or visits to the emergency department/hospitalisations. Individuals without a physical health condition living in major cities were five times more likely to have frequently visited a GP than their counterparts in outer/remote South Australia (35% and 7%, respectively), but these differences were less marked among those with multiple co‐morbidities.ConclusionThe coexistence of multiple physical health conditions among patients with a mental health problem is associated with less urban‐rural disparities in terms of visiting a GP.
Early parenting intervention promotes 24‐month psychomotor development in preterm children
Authors: Pisoni Camilla , Provenzi Livio , Moncecchi Michela , Caporali Camilla , Naboni Cecilia , Stronati Mauro , Montirosso Rosario , Borgatti Renato , Orcesi Simona 
Published: May 2020

AbstractAimAlthough parenting is key to promoting healthy development of at‐risk preterm infants, parents have often restricted access to neonatal intensive care units (NICUs). This study aimed to assess the effect of an early parenting intervention on the psychomotor outcome in preterm children at 24 months of corrected age.MethodsForty‐two preterm children and their parents were consecutively recruited at a level III NICU in Northern Italy and randomly allocated to early intervention (two educational peer‐group sessions and four individual infant observation sessions) or care as usual (no educational or infant observation sessions). During NICU stay, parents provided information on daily holding and skin‐to‐skin. Psychomotor development was measured at 24 months of corrected age using the Griffith Mental Development Scales.ResultsThere were no significant differences in socio‐demographic and clinical variables between early intervention (n = 21; 13 females) and care as usual (n = 21; 12 females) groups. At 24 months of corrected age, children in the early intervention arm had greater scores for global psychomotor development as well as for Hearing‐Speech and Personal‐Social sub‐scales, compared to those in the care as usual group.ConclusionThe present NICU parenting intervention was found to be associated with better psychomotor outcomes in preterm children at 24‐month age. The effects were especially evident for domains related to language and socio‐emotional functioning. Results are promising and should be retested with more heterogeneous and representative preterm sample.
Systematic review: management of localised low‐grade upper gastrointestinal neuroendocrine tumours
Authors: Exarchou Klaire , Howes Nathan , Pritchard David Mark 
Published: May 2020

SummaryBackgroundNeuroendocrine tumours (NETs) of the stomach and duodenum are rare, but are increasing in incidence. Optimal management of localised, low‐grade gastric and duodenal NETs remains controversial.AimsTo systematically review recent literature that has evaluated the management of localised low‐grade gastric and duodenal NETs.MethodsA systematic literature search was conducted. Articles were screened and eligible articles fully assessed. Additional articles were identified through the included articles’ reference lists.ResultsSeveral relevant retrospective case series were identified, but there was considerable heterogeneity between studies and they reported a variety of parameters. Type I gastric NETs had an excellent prognosis and conservative management approaches such as endoscopic surveillance/resection were appropriate in most cases. Many type III gastric NETs were low grade and appeared to have a better prognosis than has previously been appreciated. Endoscopic rather than surgical resection was therefore effective in some patients who had small, low‐grade tumours. Duodenal NETs were more heterogenous. Endoscopic resection was generally safe and effective in patients who had small, low‐grade, nonfunctional, non‐ampullary tumours. However, some patients, especially those with larger or ampullary duodenal NETs, required surgical resection.ConclusionsMost type I gastric NETs behave indolently and surgical resection is only rarely indicated. Some type III gastric and duodenal NETs have a worse prognosis, but selected patients who have small, localised, nonfunctional, low‐grade tumours are adequately and safely treated by endoscopic resection. Due to the complexity of this area, a multidisciplinary approach to management is strongly recommended.
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid‐like 3B
Authors: Liu Binggang , Xiao Juan , Dong Mingjun , Qiu Zhidong , Jin Junfei 
Published: May 2020

AbstractHepatocellular carcinoma (HCC) is the most common type of liver cancer. It has a poor prognosis because it is often diagnosed at the advanced stage when treatments are limited. In addition, HCC pathogenesis is not fully understood, and this has affected early diagnosis and treatment of this disease. Human alkaline ceramidase 2 (ACER2), a key enzyme that regulates hydrolysis of cellular ceramides, affects cancer cell survival, however its role in HCC has not been well characterized. Our results showed that ACER2 is overexpressed in HCC tissues and cell lines. In addition, high ACER2 protein expression was associated with tumor growth; ACER2 knockdown resulted in decreased cell growth and migration. Sphingomyelin phosphodiesterase acid‐like 3B (SMPDL3B) promoted HCC cell growth, invasion, and migration; SMPDL3B knockdown had a significant inhibitory effect on HCC tumor growth in vivo. Moreover, ACER2 positively regulated the protein level of SMPDL3B. Of note, ACER2/SMPDL3B promoted ceramide hydrolysis and S1P production. This axis induced HCC survival and could be blocked by inhibition of S1P formation. In conclusion, ACER2 promoted HCC cell survival and migration, possibly via SMPDL3B. Thus, inhibition of ACER2/SMPDL3B may be a novel therapeutic target for HCC treatment.
Potential impacts of COVID‐19 on Canadian farmland markets
Authors: Lawley Chad 
Published: May 2020

AbstractEvidence from the past 50 years suggests that changes in Canadian farmland values are influenced by farming returns, real interest rates, and exchange rates. Residential and commercial development also affects the value of farmland close to major urban centers. The COVID‐19 economic shutdown is expected to reduce crop and livestock returns, which will put downward pressure on farmland values. The magnitude of this downward pressure will depend on the extent and the length of the recession. The evolution of interest rates over the next months and years could have a significant impact on farmland values. Historically, low real interest rates have coincided with higher farmland values, whereas high real interest rates have caused significant reductions in farmland values. The development value of farmland close to major cities could be negatively impacted by a sharp downturn in residential and commercial property markets.
A genoscape‐network model for conservation prioritization in a migratory bird
Authors: Ruegg Kristen C. , Harrigan Ryan J. , Saracco James F. , Smith Thomas B. , Taylor Caz M. 
Published: May 2020

AbstractMigratory animals are declining worldwide and coordinated conservation efforts are needed to reverse current trends. We devised a novel genoscape‐network model that combines genetic analyses with species distribution modeling and demographic data to overcome challenges with conceptualizing alternative risk factors in migratory species across their full annual cycle. We applied our method to the long distance, Neotropical migratory bird, Wilson's Warbler (Cardellina pusilla). Despite a lack of data from some wintering locations, we demonstrated how the results can be used to help prioritize conservation of breeding and wintering areas. For example, we showed that when genetic, demographic, and network modeling results were considered together it became clear that conservation recommendations will differ depending on whether the goal is to preserve unique genetic lineages or the largest number of birds per unit area. More specifically, if preservation of genetic lineages is the goal, then limited resources should be focused on preserving habitat in the California Sierra, Basin Rockies, or Coastal California, where the 3 most vulnerable genetic lineages breed, or in western Mexico, where 2 of the 3 most vulnerable lineages overwinter. Alternatively, if preservation of the largest number of individuals per unit area is the goal, then limited conservation dollars should be placed in the Pacific Northwest or Central America, where densities are estimated to be the highest. Overall, our results demonstrated the utility of adopting a genetically based network model for integrating multiple types of data across vast geographic scales and better inform conservation decision‐making for migratory animals.
Larval lake sturgeon production and drift behaviour in the Menominee and Oconto Rivers, Wisconsin
Authors: Lawrence David A. , Elliott Robert F. , Donofrio Michael C. , Forsythe Patrick S. 
Published: May 2020

AbstractLake sturgeon (Acipenser fulvescens) have been negatively impacted by barriers to migration, pollution and overharvest. Biological data such as the timing of spawning activity and larval drift have provided a better understanding of larval production success or failure on a site‐specific basis. However, many river systems that serve as reproductive locations for remnant lake sturgeon populations remain understudied. The objective of this study was to compare and contrast aspects of larval lake sturgeon drift within and between the Oconto and Menominee Rivers over multiple reproductive seasons. Differences in larval drift chronology, the size of drifting larvae during the season and the cross‐sectional profile of drifting individuals as a function of river velocity were evaluated. D‐frame drift nets were deployed at a single transect below spawning sites in the Menominee (2012, 2013 and 2014) and Oconto Rivers (2013, 2014 and 2015). A total of 4,442 larvae were captured across all seasons. Larvae exhibited nonrandom drift profiles related to water velocity, and larvae size was related to horizontal drift location. The seasonal increase in body size of drifting larvae also differed among drift events within and between years and across rivers. This information will provide a better understanding of lake sturgeon early life history and has practical management connections including spawning site protection/enhancement and river flow mitigation.
Seizure‐related apneas have an inconsistent linkage to amygdala seizure spread
Authors: Park Katherine , Kanth Kiran , Bajwa Sami , Girgis Fady , Shahlaie Kiarash , Seyal Masud 
Published: May 2020

AbstractObjectiveSudden unexpected death in epilepsy (SUDEP) is a frequent cause of death in epilepsy. Respiratory dysfunction is implicated as a critical factor in SUDEP pathophysiology. Human studies have shown that electrical stimulation of the amygdala resulted in apnea, indicating that the amygdala has a role in respiration control. Unilateral amygdala stimulation resulted in immediate onset of respiratory dysfunction occurring only during nose breathing. In small numbers of patients, some but not all spontaneous seizures resulted in apnea occurring shortly after seizure spread to the amygdala. With this study we aimed to determine whether seizure onset or spread to the amygdala was necessary and sufficient to cause apnea.MethodsWe investigated the temporal relationship between apnea/hypopnea (AH) onset and initial seizure involvement within the amygdala in patients with implanted depth electrodes.ResultsData from 17 patients (11 female) with 47 seizures were analyzed. With seven seizures (three patients), AH preceded amygdala seizure involvement by 2 to 55 seconds. There was no AH with four seizures (three patients) that involved the amygdala. With eight seizures (four patients) AH occurred within 2 seconds following amygdala seizure onset. With 28 seizures, AH started >2 seconds after amygdala seizure onset (range 3‐158 seconds). Following seizure onset, there was a significant difference between AH onset time and amygdala seizure onset (P < .001). The mean ± standard deviation (SD) AH onset was 27.8 ± 41.06 seconds, and the mean time to amygdala involvement was 8.83 ± 20.19 seconds.SignificanceThere is a wide range of AH onset times relative to amygdala seizure involvement. With some seizures, amygdala seizure involvement occurs without AH. With other seizures, AH precedes amygdala seizures, suggesting that, with spontaneous seizures, involvement of the amygdala may not be crucial to induction of AH with all seizures. Other pathophysiology impacting brainstem respiratory networks may be of greater relevance to seizure‐triggered apneas.