bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explicit and implicit attachment and the outcomes of acceptance and commitment therapy and cognitive behavioral therapy for depression
Authors: A-Tjak Jacqueline G. L. , Morina Nexhmedin , Boendermaker Wouter J. , Topper Maurice , Emmelkamp Paul M. G. 
Published: April 2020

Abstract
Background
Attachment theory predicts that patients who are not securely attached may benefit less from psychological treatment. However, evidence on the predictive role of attachment in the effectiveness of treatment for depression is limited.

Methods
Explicit attachment styles, levels of attachment anxiety and attachment avoidance, as well as implicit relational self-esteem and implicit relational anxiety were assessed in 67 patients with major depressive disorder (MDD) receiving Acceptance and Commitment Therapy (ACT) or Cognitive Behavioral Therapy (CBT). ANOVA and hierarchical regression analyses were performed to investigate the predictive power of explicit and implicit attachment measures on treatment outcome.

Results
Explicit attachment avoidance at pre-treatment significantly predicted reduction of depressive symptoms following treatment. Reductions in attachment anxiety and avoidance from pre- to post-treatment predicted better treatment outcomes. Neither one of the implicit measures, nor change in these measures from pre- tot post-treatment significantly predicted treatment outcome.

Conclusions
Our findings show that attachment avoidance as well as reductions in avoidant and anxious attachment predict symptom reduction after psychological treatment for depression. Future research should use larger sample sizes to further examine the role of attachment orientation as moderator and mediator of treatment outcome.

Trial registration
clinicaltrials.gov; NCT01517503.
Subacute reconstruction using flap transfer for complex defects of the upper extremity
Authors: Kang Yongqiang , Pan Xiaoyun , Wu Yongwei , Ma Yunhong , Liu Jun , Rui Yongjun 
Published: April 2020

Abstract
Background
Despite advances in microsurgical techniques of flap transfer, complex upper extremity trauma reconstruction remains a challenge for surgeons. This study aimed to present the outcomes in using flaps in the subacute reconstruction of complex upper extremity injuries.

Methods
From July 2013 to December 2016, 35 patients ranging in age from 23 to 69 years with complicated upper extremity traumatic injuries were treated using flap reconstruction in subacute period. The number and causes of injury were 12 machine crush injuries, 18 machine strangulation injuries, two chainsaw accidents, two traffic accidents, and one incident of heavy bruising. Thirty-five patients underwent flap procedures, including 24 anterolateral thigh flaps (68.57%), five latissimus dorsi flaps (14.29%), and six lateral arm flaps (17.14%). Flap sizes ranged from 3 × 4 to 42 × 16 cm2. The mean time of flap reconstruction was 14 days (range 5–29). During postoperative follow-up, flap appearance, sensory recovery, scarring and satisfaction were assessed.

Results
The overall flap survival rate was 94.3%.Two flaps developed partial necrosis, both of which were later treated with skin grafting. Traumatic wound infections occurred in three patients. All upper limb injuries were completely covered. The follow-up periods ranged from 18 to 62 months with an average of 2.9 months. All skin flap textures were soft with varying degrees of pigmentation. Flap sensory recovery was S1 in three cases, S2 in eight cases, S3 in 15 cases, and S4 in nine cases. There were no donor site complications other than three cases with scar hyperplasia.

Conclusions
The severe upper limb soft tissue defects still achieved satisfactory function and appearance with negligible complications and low amputation rates during the subacute period.
PF4V1 affects the progression of oral squamous cell carcinoma by regulating Wnt/β-catenin pathway and angiogenesis
Authors: Li Cuiping , Jiang Weidong , Zhou Yang , Huang Xuanping , Zhou Nuo 
Published: April 2020

AbstractPlatelet factor-4 variant 1 (PF4V1) was recently described as a natural non-allelic gene variant of platelet factor-4 (PF4), which has been closely associated with the growth and metastasis of various cancers. Our previous research showed that PF4V1 was related to oral squamous cells carcinoma (OSCC) metastasis. Howerver, it is still not clear about the functional role of PF4V1 in OSCC. In this study, stably transfected cell lines were constructed and the expression level of PF4V1 was verified by real‐time polymerase chain reaction (RT-PCR) and western blot. The effect of PF4V1 on proliferation, migration, invasion, and apoptosis of oral cancer (OC) cells were detected. Moreover, a xenograft tumor model was constructed to evaluate the effect of PF4V1 on OSCC in vivo. Indicators of Wnt/β-catenin, angiogenesis and epithelial-mesenchymal transition (EMT) pathways were also examined. Stable cell lines with overexpression and inhibited expression of PF4V1 were constructed successfully. After stable transfection, PF4V1 significantly promoted the proliferation, migration, and invasion of OC cells in vitro, and their tumor formation in vivo. Furthermore, PF4V1 remarkably promoted the expression of β-catenin, VEGF, and FGF but suppressed the expression of GSK-3β. There was no statistically significant correlation between PF4V1 and EMT pathway. This study provides evidence that PF4V1 promotes the proliferation, migration, invasion and tumor formation of OC cells by regulating the Wnt/β-catenin pathway and angiogenesis. Our findings suggest that PF4V1 could be a very promising target of OSCC therapy in the future.
Decentration and tilt of plate-haptic multifocal intraocular lenses in myopic eyes
Authors: Meng Jiaqi , He Wenwen , Rong Xianfang , Miao Ao , Lu Yi , Zhu Xiangjia 
Published: April 2020

AbstractBackgroundTo investigate the decentration and tilt of plate-haptic multifocal intraocular lenses (MfIOLs) in myopic eyes.MethodsMyopic (axial length [AXL] > 24.5 mm) and non-myopic (21.0 mm < AXL ≤ 24.5 mm) cataract eyes were enrolled in this prospective study and randomly assigned to receive implantation of Zeiss AT LISA tri 839MP lenses (Group A) or Tecnis ZMB00 lenses (Group B). In total, 122 eyes of 122 patients were available for analysis. Decentration and tilt of MfIOLs, high-order aberrations (HOAs), and modulation transfer functions (MTFs) were evaluated using the OPD-Scan III aberrometer 3 months postoperatively. Subjective symptoms were assessed with a Quality of Vision questionnaire.ResultsNear and distance visual acuities, tilt and horizontal decentration did not differ between the two groups, postoperatively. However, myopic eyes of Group B showed greater vertical decentration than those of Group A (− 0.17 ± 0.14 mm vs. -0.03 ± 0.09 mm, respectively), particularly when the MfIOLs were placed horizontally or obliquely. Overall decentration of myopic eyes was greater in Group B than in Group A (0.41 ± 0.15 mm vs. 0.16 ± 0.10 mm, respectively). In Group B, AXL was negatively correlated with vertical decentration and positively correlated with overall decentration. No such correlations were found in Group A. Intraocular total HOAs, coma, trefoil and spherical aberrations were lower in Group A than in Group B for a 6.0 mm pupil among myopic eyes. Generally, Group A had better MTFs and fewer subjective symptoms than Group B among myopic eyes.ConclusionsPlate-haptic design of MfIOLs may be a suggested option for myopic cataract eyes due to the less inferior decentration and better visual quality postoperatively.
Clinical and patient-reported outcome of implant restorations with internal conical connection in daily dental practices: prospective observational multicenter trial with up to 7-year follow-up
Authors: Ackermann Karl-Ludwig , Barth Thomas , Cacaci Claudio , Kistler Steffen , Schlee Markus , Stiller Michael 
Published: April 2020

Abstract
Background
The interpretation of the results of randomized clinical trials is often questioned in relation with daily circumstances in practices. This prospective observational multicenter study was instigated to reflect the need for information in real-life situations with dental implants with internal conical implant-abutment connection (Conelog implant system). The implants were followed up at least 5-year post-loading; survival analysis (Kaplan-Meier), changes of soft tissue, and bone level over time, as well as patient satisfaction were evaluated.

Results
In total, 130 dental implants were placed in 94 patients (64 female, 30 male). Mean age of patients was 50.4 ± 13.7. At 5-year post-loading, 104 implants in 76 patients were available for evaluation. The cumulative implant survival rate was 96.6%. After an initial bone remodeling process post-surgery (bone loss of − 0.52 ± 0.55 mm), the bone level change remained clinically stable from loading to 5-year post-loading (− 0.09 ± 0.43 mm). Patient satisfaction surveyed by questionnaire (comfort, ability to chew and taste, esthetics, general satisfaction) steadily increased towards the end. At the last study follow-up, all the patients rated their general satisfaction as either very satisfied (87.5%) or satisfied (12.5%).

Conclusion
The study implants have shown to be highly effective with reliable peri-implant tissue stability over the 5 to 7 years of observation for both single tooth restorations and fixed partial dentures while used in standard conditions in daily dental practice. The results obtained are comparable with those obtained in controlled clinical trials.
First trimester fetal echocardiography limitations and its expected clinical values
Authors: Kamel Heba , Yehia Amr 
Published: April 2020

Abstract
Background
Fetal cardiac activity could be observed between 6th and 7th gestational weeks, early performance of fetal echocardiography could be implemented to screen for fetal heart disease. The effectiveness of early first trimester fetal echocardiography has not been adequately investigated, especially with modern sonographic technological advances. The purpose of the study is to evaluate the capability to visualize fetal cardiac structures within the first trimester as early as 10th gestational weeks and to elucidate the value of using color Doppler in visualization of cardiac structures within early gestation. A prospective clinical trial conducted on 150 study subjects, 44 of them were twin gestations. Cases were fully assessed by fetal echocardiographic examination from 10th gestational week to 13 gestational weeks in a sequential manner weekly. The research study was conducted at cardiology department fetal unit in one of the tertiary hospitals.

Results
Four chamber view was mostly visualized from 12 gestational weeks, whereas cardiac axis was fully visualized in all cases from 12 gestational weeks; on the other hand, IVC assessment by 2D was satisfactorily visualized in 78.26% of cases and by color Doppler in 82.61% of cases at 13 gestational weeks, pulmonary veins were visualized in 21.74% of cases by 2D and 43.5% of cases by color Doppler at 13 gestational weeks, and interestingly, ventricular inflows were satisfactorily visualized in almost all cases from 10th gestational weeks.

Conclusions
First trimester fetal echo is an outstanding enhancement in management pathways of cases susceptible to have fetal cardiac abnormalities permitting early detection of structural cardiac anomalies triggering a cascade of scanning for extra cardiac anomalies to aid in evaluation and assessment of the best management course for those affected cases.
Solanum leaves extracts exhibit antioxidant properties and inhibit monoamine oxidase and acetylcholinesterase activities (in vitro) in Drosophila melanogaster
Authors: Ogunsuyi Opeyemi B. , Ademiluyi Adedayo O. , Oboh Ganiyu 
Published: April 2020

Abstract

Background
This study sought to determine the in vitro antioxidant, anti-monoamine oxidase and anticholinesterase properties of extracts (aqueous and alkaloid) of two tropical vegetables from Solanum spp- African eggplant (Solanum macrocarpon L) and black nightshade (Solanum nigrum L) as indices of their neuroprotective properties.

Methods
Both aqueous and alkaloid extracts of African eggplant (AE) and black nightshade (BN) were prepared by solvent extraction according to standard methods. Thereafter, the inhibitory effects of the extracts on monoamine oxidase (MAO) and acetylcholinesterase (AChE) activities, as well as their free radical-scavenging and reducing abilities were assessed. Also, phytochemical analysis for phenols, flavonoids, and alkaloids were carried out.

Results
The results showed that the extracts inhibited MAO and AChE activities dose dependently, with aqueous extracts showing significantly higher MAO inhibition that the alkaloid extracts from both samples, but in all, BN showed higher MAO inhibitory effect compared to AE; the reverse was however, observed for AChE inhibition. Furthermore, the aqueous extracts showed significantly higher antioxidant properties than the alkaloid extracts, while BN had higher antioxidant properties compared to AN. The phytochemical analysis also showed that BN had significantly higher amount of phenols, flavonoids, and alkaloids than AE.

Conclusions
The anti-monoamine oxidase, anticholinesterase, and antioxidant properties exhibited by extracts from both samples could contribute to their neuroprotective abilities. Thus, these vegetables can be potential sources of functional foods and nutraceuticals in the management of neurodegenerative diseases, especially in the tropics.
Reframing the Sciences of the Long Eighteenth Century
Authors: Pancaldi Giuliano 
Published: April 2020

Here I survey a sample of the essays and reviews on the sciences of the long eighteenth century published in this journal since it was founded in 1969. The connecting thread is some historiographic reflections on the role that disciplines—in both the sciences we study and the fields we practice—have played in the development of the history of science over the past half century. I argue that, as far as disciplines are concerned, we now find ourselves a bit closer to a situation described in our studies of the long eighteenth century than we were fifty years ago. This should both favor our understanding of that period and, hopefully, make the historical studies that explore it more relevant to present-day developments and science policy.
This essay is part of a special issue entitled “Looking Backward, Looking Forward: HSNS at 50,” edited by Erika Lorraine Milam.
МЕТОДОЛОГІЧНІ ОРІЄНТАЦІЇ У ДОСЛІДЖЕННІ ПРОБЛЕМ ОСОБИСТОСТІ
Authors: Савчин Мирослав 
Published: April 2020

У статті аналізуються завдання методологічної рефлексії у сфері персонології, спрямованої на методологічну оцінку психологічних теорій та стану і завдання психологічної практики, вплив загаль­но­цивілізаційних тенденцій та внутрішній світ людини та її екзистенційні домінанти на сучасному етапі. Сформульовано завдання психології у напрямі вирішення проблем вдосконалення сучасного світу, попе­ре­дження проблем у розвитку особистості. Констатується відставання сучасної психології у дослідженні проблем персонології, яка часто пропонує неоптимальні шляхи їх вирішення, не враховує реальну онтологію людини, дається оцінка сучасній наративній психології. Акцентується увага на проблемі змісту внутріш­ньо­го світу людини, необхідність врахування її духовного Я, незорієнтованості психологічної науки на з’я­су­вання характеристик здорової особистості та оволодіння нею здоровим способом життя, з’ясуванні співвідношення індивідуального та спільнотного у природі людини, на проблемі поєднання життя людини в реальному та віртуальному світах, взаємодії з феноменами штучного інтелекту, ставиться завдання ство­рення нових методів вивчення особистості, з’ясування змісту та організації фахової психологічної освіти та аналізу досягнень української психологічної науки. Акцентується увага на необхідності вклю­чен­ня етичної проблематики в предмет психологічної науки, проблеми методологічної орієнтації персонолога та професійної відповідальності практичного психолога, вказується на деструктивні моменти у прак­тичній реалізації психологічного знання.
Phenotyping of masked hypertension based on the clustering of 24-hour blood pressure monitoring data
Authors: Geltser B. I. , Shakhgeldyan K. I. , Kotelnikov V. N. , Vetrova O. O. , Orlova-Ilyinskaya V. V. , Karpov R. S. 
Published: April 2020

Aim. Phenotyping of masked hypertension (MH) based on clustering of 24-hour ambulatory blood pressure monitoring (ABPM) results data and comparing it with indicators of target organ damage.Material and methods. We retrospectively analyzed medical records of 207 men with a median age of 34,6 years and normal office blood pressure (BP), who were systematically exposed to occupational stressors and were undergoing a routine in-patient examination. All patients underwent ABPM, echocardiography, carotid ultrasound, glomerular filtration rate estimation. The clustering of ABPM data was carried out using the Kohonen self-organizing neural networks and K-means algorithm. Data processing was performed in the R programming language using the RStudio environment.Results. MH was diagnosed in 142 (68,6%) patients which were divided into 3 clusters according to 4 criteria factors of ABPM: systolic-diastolic (SDMH) — 50,7%, isolated systolic (ISMH) — 27,5% and isolated diastolic (IDMH) — 21,8%. Majority (51,4%) of patients with SDMH were characterized by a relatively balanced distribution of episodes of increased systolic and diastolic BP during the day, and other ratios were much less common. In patients with ISMH, hypertension prevailed in the daylight, and in IDMР — nighttime. Individual clusters differed significantly in terms of the 24-hour BP profile and signs of target organ damage. Various types of cardiac remodeling were recorded in 24 (17%) patients with MH, 16 (66,7%) of which belonged to the SDMH phenotype. Intima-media thickening >0,9 mm occurred in 40% of patients with IDMH, in 30% — SDMH and only 9% — ISMH. At the same time, the majority of patients with glomerular hyperfiltration was recorded in patients with ISMH (20,5%), and with hypofiltration — IDMH (29%) and SDMH (23,6%).Conclusion. Modern technologies of clustering increase the effectiveness of risk stratification for patients with MH, and contribute to the personification of preventive and therapeutic programs.
Machine learning for predicting the outcomes and risks of cardiovascular diseases in patients with hypertension: results of ESSE-RF in the Primorsky Krai
Authors: Nevzorova V. A. , Plekhova N. G. , Priseko L. G. , Chernenko I. N. , Bogdanov D. Yu. , Mokshina M. V. , Kulakova N. V. 
Published: April 2020

Aim. To assess the prospects of using artificial intelligence technologies in predicting the outcomes and risks of cardiovascular diseases (CVD) in patients with hypertension (HTN).Material and methods. A software application was created for data mining from respondent profiles in a semi-automatic mode; libraries with data preprocessing were analyzed. We analyzed the main and additional parameters (35) of CVD risk factors in 2131 people as a part of ESSE-RF study (2014-2019). To create a forecasting model, a high-level language Python 2.7 was used using object-oriented programming and exception handling with multithreading support. Using randomization, learning (n=488) and test (n=245) samples were formed, which included data from patients with an established diagnosis of HTN.Results. The prevalence of HTN among subjects was 34,39%. There were following significant factors for predicting CVD: anthropometric parameters, smoking, biochemical profile (total cholesterol, ApoA, ApoB, glucose, D-dimer, C-reactive protein). As a result of a 5-year follow-up, CVD was found in 235 people (32,06%) with HTN and 187 people (13,38%) without HTN; mortality rates were 1,27% in subjects with HTN and 1,12% — without HTN. The absolute mortality risk among participants with HTN (0,037) was significantly higher (p<0,05) than in patients without HTN (0,017). To create a neural network (NN), the basic Sequential model from the Keras library was used. During machine learning, 26 variables important for the CVD development were used as input and 9 neurons — as output, which corresponded to the number of established cardiovascular events. The created NN had a predictive value of up to 97,9%, which exceeded the SCORE value (34,9%).Conclusion. The data obtained indicate the importance of risk factor phenotyping using anthropometric markers and biochemical profile for determining their significance in the top 20 predictors of CVD. The Python-based machine learning provides CVD prediction according to standard risk assessments.
La garantía de los derechos de la juventud: la relación gobierno municipal-organizaciones juveniles
Authors: Osorio Valencia Juli 
Published: April 2020

Este artículo de reflexión tiene por objeto estudiar la reconstrucción de las percepciones de los actores institucionales a través de los cuales se gesta el plexo de la relación gobierno municipal-organizaciones juveniles. Esta reconstrucción permitió caracterizar la concepción de fundamentalidad de losderechos y la naturaleza de la participación en la formulación de la política municipal de juventud y toma de decisiones. Este conocimiento contribuye a comprender el estado de las relaciones entre las racionalidades de los actores institucionales estatales y sociales. De una parte, analiza el problema de una gestión pública supuestamente garantista de los derechos “dentro de lo posible” del Estado (realpolitik), frente a la exigencia de asumirla como posibilidad de vida de la población joven. De otra parte, reflexiona el problema del establecimiento de criterios orientadores de la implementación y gestión de una política pública trascendente de la gobernabilidad excluyente de las expresiones individuales y organizadas de la juventud hacia la gobernanza incluyente en la realización de los derechos específicos de la juventud. O al menos, contribuye a mejorar la capacidad de los jóvenes en la exigibilidad de sus derechos.

AbstractThis article of reflection has for object study the reconstruction of the perceptions of the institutional actors across which the plexus of the relation is in preparation I govern juvenile police officer-organization. This reconstruction allowed to characterize the conception of fundamentalidad of the rights and the nature of the participation in the formulation of the municipal politics of youth and capture of decisions. This knowledge helps to understand the condition of the relations between the rationalities of the institutional state and social actors. Of a part, he analyzes the problem of a public management supposedly garantista of the rights “inside the possible thing” of the State (realpolitik), opposite to the exigency of assuming it as possibility of life of the young population. Of another part, he thinks over the problem of the establishment of criteria orientadores of the implementation and management of a public transcendent politics of the exclusive gobernabilidad of the expressions individual and organized of the youth towards the enclosing governance in the accomplishment of the specific rights of the youth. Or at least, it helps to improve the capacity of the young persons in the recoverableness of his rights.