bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTÁGIO SUPERVISIONADO REMOTO DE LÍNGUAS ESTRANGEIRAS EM TEMPOS DE PANDEMIA: experiências e percepções na UFPR
Authors: Veloso Fernanda Silva , Walesko Angela Maria Hoffman 
Published: September 2020

Este artigo objetiva compartilhar experiências de formação de professores de línguas estrangeiras ao longo de propostas que viabilizaram o estágio supervisionado, obrigatório nos cursos de licenciatura em Letras, na modalidade remota. As propostas surgiram da demanda por ações educacionais não-presenciais em função da Pandemia Covid-19, responsável pela suspensão do ano letivo presencial na Universidade Federal do Paraná (UFPR - Brasil). Os resultados iniciais deste estudo, de cunho etnográfico, partem de nossas percepções, como professoras formadoras, responsáveis pelas ações, e dos licenciandos que participaram das experiências remotas de prática de docência e estágio supervisionado, considerando crenças pessoais sobre ensinar-aprender línguas por meio de novas tecnologias. Nossas discussões sobre tais percepções fundamentam-se nas concepções sobre estágio e pesquisa no estágio, de Pimenta e Lima (2011), nas perspectivas de Schön (1994), Tardif e Moscovo (2018) quanto à formação reflexiva de professores, nas visões de Garcia da Cunha (2016) e Nogueira (2011) sobre práticas colaborativas de coensino e coaching e em discussões de Wenger (1998) e Walesko (2019) sobre comunidades de prática. A partir dessas experiências, percepções e reflexões, apresentadas no texto, sugerimos perspectivas e possibilidades de inclusão e utilização das novas tecnologias nas ações de formação docente na modalidade remota, na já citada universidade e em outras instituições de ensino superior do país.
Palavras-chave: formação inicial de professores, estágio obrigatório, ensino remoto emergencial.
PEMANFAATAN LIMBAH POPOK BAYI SEBAGAI BAHAN CAMPURAN PEMBUATAN PAVING BLOCK
Authors: L.H. Pasaribu Adriel , Basuki Basuki , Darmanijati MRS 
Published: September 2020

Popok bayi terbuat dari plastik dan campuran bahan kimia untuk menampung sisa-sisa metabolisme seperti air seni dan feses. Solusi dalam memanfaatkan limbah popok adalah dengan cara memanfaatkan hidrogel dan plastik yang terdapat di popok. Plastik yang terdapat di popok dapat dimanfaatkan menjadi suatu bahan konstruksi ringan antara lain berupa paving block karena untuk meningkatkan kuat tekan. semen dan pasir untuk dicetak menjadi balok beton.Paving block merupakan suatu komposisi bahan bangunaan yang dibuat dari campuran semen portland atau bahan perekat hidrolis sejenisnya, air, dan agregat dengan atau tanpa bahan tambahan lainnya yang tidak mengurangi mutu beton itu. Bata beton dapat bewarna seperti warna aslinya atau diberi zat warna pada komposisinya dan digunakan untuk halaman baik di dalam maupun di luar bangunaan ( SNI 03-0691-1996). Tujuan penelitian ini untuk mengetahui nilai uji Kuat Tekan dan Penyerapan Air pada penambahan limbah popok terhadap Paving Block.Â Â Metode yang digunakan dalam penelitian ini adalah metode eksperimen. Rancangan penelitian ini menggunakan Metode Regresi untuk mengetahui bagaimana pengaruh variasi campuran limbah popok yang bagus dalam pembuatan Paving Block. Bahan baku campuran semen, pasir, dan limbah popok. Perbandingan komposisi pasir dan limbah popok adalah : 1PC: 4PS: 0P, 1PC: 4PS: 0.5P, 1PC: 4PS: 1P, 1PC: 4PS: 1.5P, 1PC: 4PS: 2P, 1PC: 4PS: 2.5P, 1PC : 4PS: 3P.Hasil penelitian menunjukkan bahwa ada perbedaan antara variasi terhadap nilai kuat tekan yang dihasilkan. Namun ada pengaruh penambahan limbah popok bayi dalam paving block pada variasi terbaik dan memenuhi kuat tekan yang dikategorikan kedalam paving block mutu B yaitu pada variasi 1PC:4PS:0,5P dengan nilai kuat tekan 183,33 Kg/cm2, 1PC:4PS:1P dengan nilai kuat tekan 225,00 Kg/cm2, dan 1PC:4PS:2P dengan nilai kuat tekan 175,00 Kg/cm2, Pada mutu C pada variasi 1PC:4PS:1,5P dengan nilai kuat tekan 151,67 Kg/cm2, 1PC:4PS:2,5P dengan nilai kuat tekan 145,00 Kg/cm2, dan 1PC:4PS:3P dengan nilai kuat tekan 135,00 Kg/cm2. Pada daya serap air pada masingâ€“masing perbandingan popok bayi pada Paving Block tidak memenuhi standar SNI 03-0691 1996.
OPTIMALISASI PELAYANAN DENGAN METODE ANTRIAN PADA SPBU ABC
Authors: Vendhi Prasmoro Alloysius , Widyantoro Murwan , Warniningsih Warniningsih 
Published: September 2020

Penelitian ini bertujuan untuk menganalisis jumlah jalur fasilitas yang optimal dan kinerja waktu pelayanan yang optimal pada jalur antrian sepeda motor yang ada pada SPBU ABC. Metode analisis yang digunakan adalah analisis teori antrian dan dianalisis sebagai model multi channel-single phase. hasil dari penelitian pada SPBU ABC dengan menggunakan analisis teori antrian yaitu dengan perhitungan model multi channel-single phase. menunjukkan bahwa setelah dianalisis dengan penambahan jalur pelayanan dan juga operator bisa lebih optimal dan dari segi waktu pelayanan dari yang awalnya satu jalur pelayanan menjadi dua jalur pelayanan dan rata-rata intensitas pelayanan yang awalnya 98% menjadi 34% untuk rata-rata pelanggan dalam antrian 46 orang menjadi 1 orang dan untuk rata-rata pelanggan dalam sistem 47 orang menjadi 2 orang dan untuk rata-rataÂ waktu menunggu dalam antrian dari 58,7 menit menjadi 0,38 menit kemudian untuk rata-rata menunggu dalam sistem 60 menit menjadi 1,6 menit. Untuk itu dengan sistem multi channel single-phase atau penambahan menjadi dua jalur dari segi waktu menjadi lebih optimal.
Landmarks: A solution for spatial navigation and memory experiments in virtual reality
Authors: Starrett Michael J. , McAvan Andrew S. , Huffman Derek J. , Stokes Jared D. , Kyle Colin T. , Smuda Dana N. , Kolarik Branden S. , Laczko Jason , Ekstrom Arne D. 
Published: September 2020

AbstractResearch into the behavioral and neural correlates of spatial cognition and navigation has benefited greatly from recent advances in virtual reality (VR) technology. Devices such as head-mounted displays (HMDs) and omnidirectional treadmills provide research participants with access to a more complete range of body-based cues, which facilitate the naturalistic study of learning and memory in three-dimensional (3D) spaces. One limitation to using these technologies for research applications is that they almost ubiquitously require integration with video game development platforms, also known as game engines. While powerful, game engines do not provide an intrinsic framework for experimental design and require at least a working proficiency with the software and any associated programming languages or integrated development environments (IDEs). Here, we present a new asset package, called Landmarks, for designing and building 3D navigation experiments in the Unity game engine. Landmarks combines the ease of building drag-and-drop experiments using no code, with the flexibility of allowing users to modify existing aspects, create new content, and even contribute their work to the open-source repository via GitHub, if they so choose. Landmarks is actively maintained and is supplemented by a wiki with resources for users including links, tutorials, videos, and more. We compare several alternatives to Landmarks for building navigation experiments and 3D experiments more generally, provide an overview of the package and its structure in the context of the Unity game engine, and discuss benefits relating to the ongoing and future development of Landmarks.
Petit éloge de l’errance , de Akira Mizubayashi, Ed. Gallimard
Authors: Lastennet Pétronille 
Published: September 2020

L’auteure part de l’expérience qu’elle a de sa lecture : ‘Petit éloge de l’errance’ de Akira Mizubayashi vers une expérience d’écriture. Elle explore le passage de l’un à l’autre, se met en marche à la recherche de quelles formes sensibles ces mots coerrance, cohérence, proposés par les Cahiers de Gestalt-thérapie, pourraient revêtir, de ce qui ferait cohésion entre les deux.
La Constitution de 1958 : une conception de l’État
Authors: Denoix de Saint Marc Renaud 
Published: September 2020

La Constitution du 4 octobre 1958 porte la marque de la personnalité du général de Gaulle et de ses convictions en matière institutionnelle, au premier rang desquelles la nécessité de restaurer l’autorité de l’État. En donnant notamment un statut particulier au président de la République – désigné, dès avant la révision de 1962, comme « la clef de voûte » des institutions – et en instaurant le parlementarisme rationalisé, elle a su doter la France d’un État souverain, unitaire et efficace.
Le Général et l’Histoire
Authors: Sirinelli Jean-François 
Published: September 2020

Le général de Gaulle n’est pas seulement une figure majeure de l’histoire française, il y est doublement présent : non seulement, bien sûr, par la forte empreinte directe qu’il y a posée, mais aussi par la trace mémorielle très dense qu’il y a laissée. Ce sont donc bien deux strates, à la fois distinctes et imbriquées, qu’il convient de sonder pour rendre compte de cette place gaullienne dans notre histoire nationale.
Apport du portfolio numérique d'apprentissage et de la vidéo pour l'autoévaluation de la compétence en production orale d'élèves du secondaire en classe de français, langue d'enseignement
Authors: Paquet Maxime , Karsenti Thierry 
Published: September 2020

Cette étude part du constat que nous savons peu de choses sur l'utilisation du portfolio numérique et sur le recours aux autoévaluations dans un contexte d'apprentissage de la production orale. De ce constat découle notre cadre théorique, élaboré autour des modèles didactiques de l'oral (Dumais, 2010a ; Lafontaine, 2007) et des données empiriques portant sur l'utilisation du portfolio numérique et de l'autoévaluation, auxquels nous souhaitons apporter de nouvelles données grâce à notre recherche, dont l'objectif est de décrire et d'analyser l'apport du portfolio numérique pour l'autoévaluation de la compétence orale d'élèves du secondaire. Pour atteindre cet objectif, nous avons analysé globalement les autoévaluations contenues dans les portfolios et les réponses à deux questionnaires de 77 élèves de 3ème secondaire (N = 77), puis, de manière plus précise, nous avons analysé le contenu des autoévaluations de 16 de ces élèves (N = 16), qui ont également participé à une entrevue individuelle. Notre collecte de données nous a permis de décrire de quelle manière le recours au portfolio numérique d'apprentissage permettait d'accroître la capacité des élèves à s'autoévaluer.
A Genetic Model of Constitutively Active Integrin CD11b/CD18
Authors: Martinez Laisel , Li Xiaobo , Ramos-Echazabal Gioser , Faridi Hafeez , Zigmond Zachary M. , Santos Falcon Nieves , Hernandez Diana R. , Shehadeh Serene A. , Velazquez Omaida C. , Gupta Vineet , Vazquez-Padron Roberto I. 
Published: September 2020

Abstract
Pharmacological activation of integrin CD11b/CD18 (αMβ2, Mac-1, and CR3) shows anti-inflammatory benefits in a variety of animal models of human disease, and it is a novel therapeutic strategy. Reasoning that genetic models can provide an orthogonal and direct system for the mechanistic study of CD11b agonism, we present in this study, to our knowledge, a novel knock-in model of constitutive active CD11b in mice. We genetically targeted the Itgam gene (which codes for CD11b) to introduce a point mutation that results in the I332G substitution in the protein. The I332G mutation in CD11b promotes an active, higher-affinity conformation of the ligand-binding I/A-domain (CD11b αA-domain). In vitro, this mutation increased adhesion of knock-in neutrophils to fibrinogen and decreased neutrophil chemotaxis to a formyl–Met–Leu–Phe gradient. In vivo, CD11bI332G animals showed a reduction in recruitment of neutrophils and macrophages in a model of sterile peritonitis. This genetic activation of CD11b also protected against development of atherosclerosis in the setting of hyperlipidemia via reduction of macrophage recruitment into atherosclerotic lesions. Thus, our animal model of constitutive genetic activation of CD11b can be a useful tool for the study of integrin activation and its potential contribution to modulating leukocyte recruitment and alleviating different inflammatory diseases.
Staphylococcal Enterotoxin C2 Mutant–Directed Fatty Acid and Mitochondrial Energy Metabolic Programs Regulate CD8+ T Cell Activation
Authors: Fu Xuanhe , Xu Mingkai , Zhang Huiwen , Li Yongqiang , Li Yansheng , Zhang Chenggang 
Published: September 2020

Abstract
CD8+ T cells can switch between fatty acid catabolism and mitochondrial energy metabolism to sustain expansion and their cytotoxic functions. ST-4 is a TCR-enhanced mutant derived from superantigen staphylococcal enterotoxin C2 (SEC2), which can hyperactivate CD4+ T cells without MHC class II molecules. However, whether ST-4/SEC2 can enhance metabolic reprogramming in CD8+ T cells remains poorly understood. In this study, we found that ST-4, but not SEC2, could induce proliferation of purified CD8+ T cell from BALB/c mice in Vβ8.2- and -8.3–specific manners. Results of gas chromatography–mass spectroscopy analysis showed that fatty acid contents in CD8+ T cells were increased after ST-4 stimulation. Flow cytometry and Seahorse analyses showed that ST-4 significantly promoted mitochondrial energy metabolism in CD8+ T cells. We also observed significantly upregulated levels of gene transcripts for fatty acid uptake and synthesis, and significantly increased protein expression levels of fatty acid and mitochondrial metabolic markers of mTOR/PPARγ/SREBP1 and p38-MAPK signaling pathways in ST-4–activated CD8+ T cells. However, blocking mTOR, PPARγ, SREBP1, or p38-MAPK signals with specific inhibitors could significantly relieve the enhanced fatty acid catabolism and mitochondrial capacity induced by ST-4. In addition, blocking these signals inhibited ST-4–stimulated CD8+ T cell proliferation and effector functions. Taken together, our findings demonstrate that ST-4 enhanced fatty acid and mitochondria metabolic reprogramming through mTOR/PPARγ/SREBP and p38-MAPK signaling pathways, which may be important regulatory mechanisms of CD8+ T cell activation. Understanding the effects of ST-4–induced regulatory metabolic networks on CD8+ T cells provide important mechanistic insights to superantigen-based tumor therapy.
A Complement C3–Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
Authors: Pedersen Henrik , Jensen Rasmus K. , Jensen Jens Magnus B. , Fox Rachel , Pedersen Dennis V. , Olesen Heidi G. , Hansen Annette G. , Christiansen Dorte , Mazarakis Sofia M. M. , Lojek Neal , Hansen Pernille , Gadeberg Trine A. F. , Zarantonello Alessandra , Laursen Nick S. , Mollnes Tom Eirik , Johnson Matthew B. , Stevens Beth , Thiel Steffen , Andersen Gregers R. 
Published: September 2020

Abstract
The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing complement regulatory and inhibitory agents to treat complement dysfunction. In this study, we describe the nanobody hC3Nb3, which is specific for the C-terminal C345c domain of human and mouse complement component C3/C3b/C3c and potently inhibits C3 cleavage by the alternative pathway. A high-resolution structure of the hC3Nb3–C345c complex explains how the nanobody blocks proconvertase assembly. Surprisingly, although the nanobody does not affect classical pathway–mediated C3 cleavage, hC3Nb3 inhibits classical pathway–driven hemolysis, suggesting that the C-terminal domain of C3b has an important function in classical pathway C5 convertase activity. The hC3Nb3 nanobody binds C3 with low nanomolar affinity in an SDS-resistant complex, and the nanobody is demonstrated to be a powerful reagent for C3 detection in immunohistochemistry and flow cytometry. Overall, the hC3Nb3 nanobody represents a potent inhibitor of both the alternative pathway and the terminal pathway, with possible applications in complement research, diagnostics, and therapeutics.
High-flow nasal cannula for Acute Respiratory Distress Syndrome (ARDS) due to COVID-19
Authors: Panadero Carolina , Abad-Fernández Araceli , Rio-Ramírez Mª Teresa , Acosta Gutiérrez Carmen Maria , Calderón-Alcalá Mariara , López-Riolobos Cristina , Matesanz-López Cristina , Garcia-Prieto Fernando , Diaz-Garcia Jose Maria , Raboso-Moreno Beatriz , Vasquez-Gambasica Zully , Andres-Ruzafa Pilar , García-Satué Jose Luis , Calero-Pardo Sara , Sagastizabal Belen , Bautista Diego , Campos Alfonso , Gonzalez Marina , Grande Luis , Jimenez Fernandez Marta , Santiago-Ruiz Jose L. , Caravaca Perez Pedro , Alcaraz Andres Jose 
Published: September 2020

Background: High-flow nasal cannula oxygen therapy (HFNC) has been shown to be a useful therapy in the treatment of patients with Acute Respiratory Distress Syndrome (ARDS), but its efficacy is still unknown in patients with COVID-19. Our objective is to describe its utility as therapy for the treatment of ARDS caused by SARS-CoV-2. Methods: A retrospective, observational study was performed at a single centre, evaluating patients with ARDS secondary to COVID-19 treated with HFNC. The main outcome was the intubation rate at day 30, which defined failure of therapy. We also analysed the role of the ROX index to predict the need for intubation.Results: In the study period, 196 patients with bilateral pneumonia were admitted to our pulmonology unit, 40 of whom were treated with HFNC due to the presence of ARDS. The intubation rate at day 30 was 52.5%, and overall mortality was 22.5%. After initiating HFNC, the SpO2/FiO2 ratio was significantly better in the group that did not require intubation (113.4±6.6 vs 93.7±6.7, p=0.020), as was the ROX index (5.0±1.6 vs 4.0±1.0, p=0.018). A ROX index less than 4.94 measured 2 to 6 h after the start of therapy was associated with increased risk of intubation (HR 4.03 [95% CI 1.18 – 13.7]; p=0.026).Conclusion: High-flow therapy is a useful treatment in ARDS in order to avoid intubation or as a bridge therapy, and no increased mortality was observed secondary to the delay in intubation. After initiating HFNC, a ROX index below 4.94 predicts the need for intubation.
Supervisor Perceptions of Newly Credentialed Athletic Trainers' Transition to Practice
Authors: Compton Samantha , Simon Janet E. , Harris Laura L. 
Published: September 2020

Context
Transition to practice for newly credentialed athletic trainers (ATs) has been described through the perspective of educators, supervisors of graduate assistant ATs, students, and recent graduates; however, the opinion of supervisors of full-time ATs has not been thoroughly investigated.

Objective
(1) Describe supervisor perceptions of the transition to full-time practice for newly credentialed ATs and (2) describe current onboarding processes used by employers.

Design
Phenomenological qualitative study.

Setting
Semistructured interviews.

Patients or Other Participants
Purposive sample of 10 (4 men, 6 women) supervisors of newly credentialed ATs. Supervisors reported an average of 13.5 years of supervisory experience (range, 5–26 years).

Data Collection and Analysis
Questions addressed supervisor expectations, strengths and weaknesses of newly credentialed ATs, and the organization's onboarding process. The primary researcher transcribed audio recordings and each participant reviewed transcripts. Two researchers coded themes using an inductive process; a peer auditor completed an independent review. Disagreements were negotiated until consensus was reached.

Results
Two categories emerged: (1) characteristics of newly credentialed ATs and (2) onboarding strategies. The first category was organized into 2 subcategories: (1) knowledge, skills, and abilities (KSAs) and (2) unrealistic job expectations. The majority of supervisors felt that newly credentialed ATs were knowledgeable; however, the translation of knowledge into practice was viewed as an area requiring mentorship. Participants also reported that newly credentialed ATs often were poorly informed of the work schedule and time demands. In regard to onboarding processes, the researchers identified 7 different strategies reported by supervisors.

Conclusions
Newly credentialed ATs were perceived as knowledgeable but struggling to transition knowledge to clinical practice and often did not understand the work demands. Seven onboarding strategies were reported by participants; each of these can be used to develop KSAs of newly credentialed ATs. The KSAs should be addressed through a yearlong process consisting of orientations, shadowing, mentorship, seminars, and skill assessments.
Effectiveness of Sterile Insect Technique for Medfly (Ceratitis capitata, Wiedemann, 1824) Control in Citrus Orchards of Moulouya Perimeter North East of Morocco
Authors: Jamal BEN YAZID  , Z. CHAFIK  , I. BIBI  , E. KHARMACH  
Published: September 2020

The Sterile Insect Technique (SIT) is an effective pest control method developed worldwide against many species of Fruit Flies. It involves the release of male insects sterilized, at pupae instar, by exposure to ionizing radiation. The Area-wide control of medfly (Ceratitis capitata), with SIT based on sterile males release combined to other control techniques, was implemented since 2017 as a pilot area in Moulouya Perimeter in North-eastern Morocco. The main objective of this study is to evaluate the effectiveness of this tool in controlling Medfly and estimate sterile male population densities from data collected from trap catches after the release of a pre-determined number of sterile males in five Citrus orchards (0, 500, 1000 and 3000 sterile males per hectare) and the calculation of FTD (fly/trap/day) of sterile and wild males. The result showed that the percentage of recaptured males and FTD Sterile indices were related to release density by power function regression, while the sterile to wild ratio and release density were linear regression-adjusted. The finding confirmed the effectiveness of release in reducing the fly population in the TIS area by reducing the rate of citrus infestation in field and export shipments.