bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crossmodal Correspondence Between Tonal Hierarchy and Visual Brightness: Associating Syntactic Structure and Perceptual Dimensions Across Modalities
Authors: Maimon Neta B. , Lamy Dominique , Eitan Zohar 
Published: May 2020

Abstract
Crossmodal correspondences (CMC) systematically associate perceptual dimensions in different sensory modalities (e.g., auditory pitch and visual brightness), and affect perception, cognition, and action. While previous work typically investigated associations between basic perceptual dimensions, here we present a new type of CMC, involving a high-level, quasi-syntactic schema: music tonality. Tonality governs most Western music and regulates stability and tension in melodic and harmonic progressions. Musicians have long associated tonal stability with non-auditory domains, yet such correspondences have hardly been investigated empirically. Here, we investigated CMC between tonal stability and visual brightness, in musicians and in non-musicians, using explicit and implicit measures. On the explicit test, participants heard a tonality-establishing context followed by a probe tone, and matched each probe to one of several circles, varying in brightness. On the implicit test, we applied the Implicit Association Test to auditory (tonally stable or unstable sequences) and visual (bright or dark circles) stimuli. The findings indicate that tonal stability is associated with visual brightness both explicitly and implicitly. They further suggest that this correspondence depends only partially on conceptual musical knowledge, as it also operates through fast, unintentional, and arguably automatic processes in musicians and non-musicians alike. By showing that abstract musical structure can establish concrete connotations to a non-auditory perceptual domain, our results open a hitherto unexplored avenue for research, associating syntactical structure with connotative meaning.
Olfactory Costimulation Influences Intranasal Somatosensory Perception
Authors: Karunanayaka Prasanna R. , Lu Jiaming , Yang Qing X. , Sathian K. 
Published: May 2020

Abstract
Olfactory sensitivity is influenced by intranasal trigeminal sensation. For instance, sniffing is central to how humans and animals perceive odorants. Here, we investigated the influence of olfactory costimulation on the perception of intranasal somatosensory stimulation. In this study, 22 healthy human subjects, with normal olfactory function, performed a localization task for stimulation using weak air puffs, a pure odorant, phenyl ethyl alcohol (PEA; rose odor), or their combination. Visual cues were used to inform participants to briefly hold their breath while weak, poorly localizable, air puffs and/or PEA were delivered to either nostril. Although PEA alone could not be localized to the correct nostril, when it accompanied a weak air puff in the ipsilateral nostril, localization accuracy significantly improved, relative to presentation of the air puff without the odorant. The enhancement of localization was absent when the air puff and PEA were presented to opposite nostrils. Since ipsilateral but not contralateral costimulation with PEA increased the accuracy of weak air puff localization, the results argue against a non-specific alerting effect of PEA. These findings suggest an interaction between olfactory and intranasal somatosensory stimuli leading to their integration.
Comparison of ED95 of Butorphanol and Sufentanil for gastrointestinal endoscopy sedation: a randomized controlled trial
Authors: Zhu Xiaona , Chen Limei , Zheng Shuang , Pan Linmin 
Published: May 2020

Abstract
Background
Butorphanol, a synthetic opioid partial agonist analgesic, has been widely used to control perioperative pain. However, the ideal dose and availability of butorphanol for gastrointestinal (GI) endoscopy are not well known. The aim of this study was to evaluated the 95% effective dose (ED95) of butorphanol and sufentanil in GI endoscopy and compared their clinical efficacy, especially regarding the recovery time.

Methods
The study was divided into two parts. For the first part, voluntary patients who needed GI endoscopy anesthesia were recruited to measure the ED95 of butorphanol and sufentanil needed to achieve successful sedation before GI endoscopy using the sequential method (the Dixon up-and-down method). The second part was a double-blind, randomized study. Two hundred cases of painless GI endoscopy patients were randomly divided into two groups (n = 100), including group B (butorphanol at the ED95 dose) and group S (sufentanil at the ED95 dose). Propofol was infused intravenously as the sedative in both groups. The recovery time, visual analogue scale (VAS) score, hand grip strength, fatigue severity scores, incidence of nausea and vomiting, and incidence of dizziness were recorded.

Results
The ED95 of butorphanol for painless GI endoscopy was 9.07 μg/kg (95% confidence interval: 7.81–19.66 μg/kg). The ED95 of sufentanil was 0.1 μg/kg (95% CI, 0.079–0.422 μg/kg). Both butorphanol and sufentanil provided a good analgesic effect for GI endoscopy. However, the recovery time for butorphanol was significantly shorter than that for sufentanil (P < 0.05, group B vs. group S:21.26 ± 7.70 vs. 24.03 ± 7.80 min).

Conclusions
Butorphanol at 9.07 μg/kg was more effective than sufentanil for GI endoscopy sedation and notably reduced the recovery time.

Trial registration
Chinese Clinical Trail Registry (Registration number # ChiCTR1900022780; Date of Registration on April 25rd, 2019).
Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
Authors: Kim Jun Hyung , Moon Jin Sil , Byun Seok Joon , Lee Jun Hyeok , Kang Dae Ryong , Sung Ki Chul , Kim Jang Young , Huh Ji Hye 
Published: May 2020

Abstract
Background
Despite the known association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD), whether NAFLD predicts future CVD events, especially CVD mortality, remains uncertain. We evaluated the relationship between fatty liver index (FLI), a validated marker of NAFLD, and risk of major adverse cardiac events (MACEs) in a large population-based study.

Methods
We identified 3011,588 subjects in the Korean National Health Insurance System cohort without a history of CVD who underwent health examinations from 2009 to 2011. The primary endpoint was a composite of cardiovascular deaths, non-fatal myocardial infarction (MI), and ischemic stroke. A Cox proportional hazards regression analysis was performed to assess association between the FLI and the primary endpoint.

Results
During the median follow-up period of 6 years, there were 46,010 cases of MACEs (7148 cases of cardiovascular death, 16,574 of non-fatal MI, and 22,288 of ischemic stroke). There was a linear association between higher FLI values and higher incidence of the primary endpoint. In the multivariable models adjusted for factors, such as body weight and cholesterol levels, the hazard ratio for the primary endpoint comparing the highest vs. lowest quartiles of the FLI was 1.99 (95% confidence interval [CIs], 1.91–2.07). The corresponding hazard ratios (95% CIs) for cardiovascular death, non-fetal MI, and ischemic stroke were 1.98 (1.9–2.06), 2.16 (2.01–2.31), and 2.01 (1.90–2.13), respectively (p < 0.001). The results were similar when we performed stratified analyses by age, sex, use of dyslipidemia medication, obesity, diabetes, and hypertension.

Conclusions
Our findings indicate that the FLI, which is a surrogate marker of NAFLD, has prognostic value for detecting individuals at higher risk for cardiovascular events.
Water intake and intra-meal fluid consumption in relation to general and abdominal obesity of Iranian adults
Authors: Salari-Moghaddam Asma , Aslani Negar , Saneei Parvane , Keshteli Ammar Hassanzadeh , Daneshpajouhnejad Parnaz , Esmaillzadeh Ahmad , Adibi Peyman 
Published: May 2020

Abstract
Objective
The aim of this study was to examine the association between whole-day water intake and intra-meal fluid consumption and odds of general and abdominal obesity among adults.

Methods
This cross-sectional study was conducted among 7958 adults in Isfahan, Iran. Daily water consumption was assessed through the use of a pre-tested questionnaire by asking questions about the average number of glasses of water consumed in a day. Intra-meal fluid consumption was also analysed. Data regarding height, weight and waist circumference were collected using a validated self-administered questionnaire. Obesity was defined as body mass index ≥30 kg/m2, and abdominal obesity was defined as waist circumference >88 cm for women and >102 cm for men.

Results
After taking potential confounders into account, individuals who were taking more than eight glasses of water in a day had 78% greater odds of general obesity (OR: 1.78; 95% CI: 1.08–2.94) compared with those who were taking less than two glasses of water. Individuals with much water intake had no significant greater odds of abdominal obesity. Compared with those who were consuming less than a glass of intra-meal fluids, subjects with 1–2 glasses of fluids between meals had 34% greater odds of general obesity (OR: 1.34; 95% CI: 1.04–1.59). Although subjects with greater intra-meal fluid intake had greater odds of abdominal obesity in crude model, this association became non-significant after adjustment for potential confounders (comparing > 4 glasses vs. ≤1 glass: OR: 1.65; 95% CI: 0.81–3.34).

Conclusions
We observed that taking more than eight glasses of water in a day and consuming 1–2 glasses of fluids between meals was associated with greater odds of general obesity.
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy
Authors: Wang Xueping , Wang Fang , Zhong Mengjun , Yarden Yosef , Fu Liwu 
Published: May 2020

AbstractImmune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers. However, low response rates to ICI monotherapies and even hyperprogressive disease (HPD) have limited the clinical application of ICIs. HPD is a novel pattern of progression, with an unexpected and fast progression in tumor volume and rate, poor survival of patients and early fatality. Considering the limitations of ICI due to HPD incidence, valid biomarkers are urgently needed to predict the occurrence of HPD and the efficacy of ICI. Here, we reviewed and summarized the known biomarkers of HPD, including tumor cell biomarkers, tumor microenvironment biomarkers, laboratory biomarkers and clinical indicators, which provide a potential effective approach for selecting patients sensitive to ICI cancer treatments.
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
Authors: Shrestha Stal , Kim Min-Jeong , Eldridge Mark , Lehmann Michael L. , Frankland Michael , Liow Jeih-San , Yu Zu-Xi , Cortes-Salva Michelle , Telu Sanjay , Henter Ioline D. , Gallagher Evan , Lee Jae-Hoon , Fredericks J. Megan , Poffenberger Chelsie , Tye George , Ruiz-Perdomo Yanira , Anaya Fernanda Juarez , Montero Santamaria Jose A. , Gladding Robert L. , Zoghbi Sami S. , Fujita Masahiro , Katz James D. , Pike Victor W. , Innis Robert B. 
Published: May 2020

Abstract
Background
Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing inflammatory response in the brain and periphery. To date, however, the development of PET radioligands for COX-2 has had limited success.

Methods
The novel PET tracer [11C]MC1 was used to examine COX-2 expression [1] in the brains of four rhesus macaques at baseline and after injection of the inflammogen lipopolysaccharide (LPS) into the right putamen, and [2] in the joints of two human participants with rheumatoid arthritis and two healthy individuals. In the primate study, two monkeys had one LPS injection, and two monkeys had a second injection 33 and 44 days, respectively, after the first LPS injection. As a comparator, COX-1 expression was measured using [11C]PS13.

Results
COX-2 binding, expressed as the ratio of specific to nondisplaceable uptake (BPND) of [11C]MC1, increased on day 1 post-LPS injection; no such increase in COX-1 expression, measured using [11C]PS13, was observed. The day after the second LPS injection, a brain lesion (~ 0.5 cm in diameter) with high COX-2 density and high BPND (1.8) was observed. Postmortem brain analysis at the gene transcript or protein level confirmed in vivo PET results. An incidental finding in an unrelated monkey found a line of COX-2 positivity along an incision in skull muscle, demonstrating that [11C]MC1 can localize inflammation peripheral to the brain. In patients with rheumatoid arthritis, [11C]MC1 successfully imaged upregulated COX-2 in the arthritic hand and shoulder and apparently in the brain. Uptake was blocked by celecoxib, a COX-2 preferential inhibitor.

Conclusions
Taken together, these results indicate that [11C]MC1 can image and quantify COX-2 upregulation in both monkey brain after LPS-induced neuroinflammation and in human peripheral tissue with inflammation.

Trial registration
ClinicalTrials.gov NCT03912428. Registered April 11, 2019.
Indoor positioning and wayfinding systems: a survey
Authors: Kunhoth Jayakanth , Karkar AbdelGhani , Al-Maadeed Somaya , Al-Ali Abdulla 
Published: May 2020

AbstractNavigation systems help users access unfamiliar environments. Current technological advancements enable users to encapsulate these systems in handheld devices, which effectively increases the popularity of navigation systems and the number of users. In indoor environments, lack of Global Positioning System (GPS) signals and line of sight with orbiting satellites makes navigation more challenging compared to outdoor environments. Radio frequency (RF) signals, computer vision, and sensor-based solutions are more suitable for tracking the users in indoor environments. This article provides a comprehensive summary of evolution in indoor navigation and indoor positioning technologies. In particular, the paper reviews different computer vision-based indoor navigation and positioning systems along with indoor scene recognition methods that can aid the indoor navigation. Navigation and positioning systems that utilize pedestrian dead reckoning (PDR) methods and various communication technologies, such as Wi-Fi, Radio Frequency Identification (RFID) visible light, Bluetooth and ultra-wide band (UWB), are detailed as well. Moreover, this article investigates and contrasts the different navigation systems in each category. Various evaluation criteria for indoor navigation systems are proposed in this work. The article concludes with a brief insight into future directions in indoor positioning and navigation systems.
Technology Enhanced Assessment (TEA) in COVID 19 Pandemic
Authors: Khan Rehan Ahmed , Jawaid Masood 
Published: May 2020

Online teaching and learning is not a new phenomenon. For the last many years, it has been mainly used as a part of face to face teaching. Assessment is an essential part of teaching and learning, as it establishes the achievement of course learning outcomes by the students. Computer-based assessment is in place for a long time now, however, online assessments have been less practiced. This is because of the issues of validity, reliability and dishonesty. During the COVID 19 pandemic, the educational environment has taken a paradigm shift in many medical schools, both nationally and internationally. This situation demands a method of assessment that is safe, valid, reliable, acceptable, feasible and fair. This paper describes the different formats of online assessment and their application in formative and summative assessments during and after the COVID 19 pandemic.
doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2795
How to cite this:Khan RA, Jawaid M. Technology Enhanced Assessment (TEA) in COVID 19 Pandemic. Pak J Med Sci. 2020;36(COVID19-S4):COVID19-S108-S110. doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2795
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Status Fitonematoda pada Tiga Kisaran Umur Lahan Pertanaman Pisang Cavendish di Way Kambas, Lampung
Authors: Yanto Yanto , Swibawa I Gede 
Published: May 2020

Crop losses due to phytonematodes infection commonly occurred on intensive plantation practiced for a long time. The research was aimed to study phytonematodes status on several age-different plantation of Cavendish banana in PT NTF Way Kambas, Lampung. Soil and root samples were taken from three different plantations, selected based on time period of cultivation practice, i.e. 3–5, 10–12, and 17–19 years long. The modification of Baermann funnel method was applied to collect nematodes. The status of phytonematodes were determined based on the absolute frequency (AF), relative frequency (RF), and absolute population (AP) of each genus. The results showed that 13 phytonematodes genera inhabited Cavendish banana crops. Pratylenchus and Radopholus have important status on a land that had been cultivated for 3–5 and 10–12 years with AF 100%, RF 31%, and AP 298.8, and 423.0 individues per 200 mL of soil, respectively on 3–5 years long lands, and AF100%, RF 39% and PA 215, and 126 individues per 200 mL of soil, respectively on 10–12 years long lands. Pratylenchus and Radopholus were less important on 17–19 years long rotated lands with AF 77%, RF 22% and AP 33.0 and 16.4 individues per 200 mL of soil respectively. The status of other phytonematodes were not important with low value of AF, RF, and AP.
Penapisan Cendawan Trichoderma spp. untuk Pengendalian Phytophthora infestans secara in vitro
Authors: Purwantisari Susiana , Priyatmojo Achmadi , Sancayaningsih Retno Peni , Kasiamdari Rina Sri 
Published: May 2020

Late blight disease on potato caused by a plant pathogenic fungus (Phytophthora infestans) is the most important disease in Indonesia. The use of antagonist fungi Trichoderma is an environmentally friendly technology to control the potato disease. The purpose of this study was to determine the ability of Trichoderma spp. to control P. infestans in vitro. Trichoderma spp. have been isolated from suppressive soil at central potato areas in district of Lembang, Bandung, West Java Province. To determine the inhibition ability of Trichoderma spp against P. infestans, a dual culture method was performed. Variable observed was inhibition zone of Trichoderma spp. against P. infestans. The results showed that 9 isolates of Trichoderma were successfuly isolated from suppressive soil, i.e. T. viride (2 isolates), T. atroviride (1 isolate), T. harzianum (1 isolate) and T. aureoviride (5 isolates). All the Trichoderma isolates revealed growth inhibition abality against P. infestans and. The highest growth inhibition (68.6%) was observed by T. viride isolate ( Ti 9).
Dampak Penyakit Tanaman terhadap Pendapatan Petani Kubis-kubisan di Daerah Agropolitan Kabupaten Cianjur, Jawa Barat
Authors: Pratama Teguh , Suastika Gede , Nurmansyah Ali 
Published: May 2020

Cruciferous vegetables are very important agricultural commodities for increasing farmers income. The main obstacles in their cultivation involved among others high level of pathogen infestation that may cause reduction in farmer’s income. This research was conducted to determine the main pathogens and their impact on farmer income in Agropolitan area of Cianjur Regency, West Java Province. The research was conducted through three activities, i.e. farmer survey, identification of the main pathogens, and measurement of disease intensity. The results showed that there were three main pathogens on assessed cruciferous vegetables, i.e. Alternaria brassiccicola (alternaria leaf spot), Plasmodiophora brassicae (clubroot), and Xanthomonas campestris (black rot), with disease intensity of 16.7%, 18.7%, and 15.1%, respectively. Clubroot disease was the most affecting disease in decreasing the production of cruciferous vegetables and the farmer income. Incidence of clubroot disease with an average disease intensity of 16.67% might lead to the decrease of farming income about 24%–28%.
Resting Metabolic Rate in Female Rugby Players: Differences in Measured Versus Predicted Values
Authors: O'Neill Jack Eoin Rua G. , Walsh Ciara S. , McNulty Senan J. , Gantly Hannah C. , Corish Martha E. , Crognale Domenico , Horner Katy 
Published: May 2020

Abstract
O'Neill, JERG, Walsh, CS, McNulty, SJ, Gantly, HC, Corish, ME, Crognale, D, and Horner, K. Resting metabolic rate in female rugby players: differences in measured versus predicted values. J Strength Cond Res 36(3): 845–850, 2022—This study investigated (a) the accuracy of resting metabolic rate (RMR) prediction equations in female rugby players and (b) factors that might explain poor prediction accuracy in some individuals. Resting metabolic rate was assessed in 36 female elite and subelite rugby players (age: 18–35 years, fat-free mass (FFM): 43–63 kg, fat mass %: 15–41%). After pretest standardization (24-hour exercise avoidance and 12-hour overnight fast), RMR was measured by indirect calorimetry and compared with predicted values determined by Harris-Benedict, Cunningham, Ten Haaf, Jagim and Watson equations. Body composition was assessed by air displacement plethysmography, muscle damage indicated by creatine kinase, and risk of low energy availability (LEA) by LEA in Females Questionnaire. Measured RMR was 1,651 ± 167 kcal·d−1. The Cunningham, Ten Haaf, and Watson (body mass) predicted values did not differ from measured (p > 0.05), while all other predicted values differed significantly (p < 0.001). Individually, prediction accuracy to within 10% varied widely depending on the equation used (range 44% [n = 16] to 86% [n = 31]). Three of the 5 individuals whose values were outside 10% of the measured value using the best performing Ten Haaf FFM equation could be explained by muscle damage or LEA. These measures may be useful to assist in understanding why measured RMR may be lower or higher than predicted in some athletes. Overall, the Ten Haaf equations showed the best accuracy, suggesting these equations may be most suitable for this population. The findings demonstrate the importance of considering the population studied when determining the most appropriate prediction equation to use.