bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study
Authors: Buono Giuseppe , Crispo Anna , Giuliano Mario , De Angelis Carmine , Schettini Francesco , Forestieri Valeria , Lauria Rossella , De Laurentiis Michelino , De Placido Pietro , Rea Carmen Giusy , Pacilio Carmen , Esposito Emanuela , Grimaldi Maria , Nocerino Flavia , Porciello Giuseppe , Giudice Aldo , Amore Alfonso , Minopoli Anita , Botti Gerardo , De Placido Sabino , Trivedi Meghana V. , Arpino Grazia 
Published: June 2020

Abstract
Purpose
Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients’ outcome.

Methods
MetS was defined by the presence of 3 to 5 of the following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels of triglycerides ≥ 150 mg/dL, high density lipoprotein < 50 mg/dL and fasting glucose ≥ 110 mg/dL. Seven hundred and seventeen patients with data on ≥ 4 MetS components at BC diagnosis were enrolled. Study population was divided into two groups: patients with < 3 (non-MetS) vs. ≥ 3 components (MetS). Categorical variables were analyzed by Chi-square test and survival data by log-rank test and Cox proportional hazards regression model.

Results
Overall, 544 (75.9%) and 173 (24.1%) women were categorized as non-MetS and MetS, respectively. MetS patients were more likely to be older, postmenopausal, and insulin-resistant compared to non-MetS patients (p < 0.05). In multivariate analysis, MetS patients had a numerically higher risk of relapse [disease-free survival (DFS), hazard ratio (HR) 1.51, p = 0.07] and a significantly higher risk of death compared to non-MetS patients [overall survival (OS), HR 3.01, p < 0.0001; breast cancer-specific survival (BCSS), HR 3.16, p = 0.001]. Additionally, patients with 1 to 2 components of MetS had an increased risk of dying compared to patients with 0 components (OS, HR 4.90, p = 0.01; BCSS, HR 6.07, p = 0.02).

Conclusions
MetS correlated with poor outcome in eBC patients. Among patients without full criteria for MetS diagnosis, the presence of 1 or 2 components of the syndrome may predict for worse survival.
Integrative analysis of key candidate genes and signaling pathways in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy by bioinformatics
Authors: Zhang Ying , Garofano Francesca , Wu Xiaolong , Schmid Matthias , Krawitz Peter , Essler Markus , Schmidt-Wolf Ingo G. H. 
Published: June 2020

SummaryCytotoxic T lymphocyte-associated antigen-4 (CTLA-4), the first immune checkpoint to be targeted clinically, has provided an effective treatment option for various malignancies. However, the clinical advantages associated with CTLA-4 inhibitors can be offset by the potentially severe immune-related adverse events (IRAEs), including autoimmune thyroid dysfunction. To investigate the candidate genes and signaling pathways involving in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy, integrated differentially expressed genes (DEGs) were extracted from the intersection of genes from Gene Expression Omnibus (GEO) datasets and text mining. The functional enrichment was performed by gene ontology (GO) annotation and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Protein-protein interaction (PPI) network, module enrichment, and hub gene identification were constructed and visualized by the online Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape software. A total of 22 and 17 integrated human DEGs in hypothyroidism and hyperthyroidism group related to anti-CTLA-4 therapy were identified, respectively. Functional enrichment analysis revealed 24 GO terms and 1 KEGG pathways in the hypothyroid group and 21 GO terms and 2 KEGG pathways in the hyperthyroid group. After PPI network construction, the top five hub genes associated with hypothyroidism were extracted, including ALB, MAPK1, SPP1, PPARG, and MIF, whereas those associated with hyperthyroidism were ALB, FCGR2B, CD44, LCN2, and CD74. The identification of the candidate key genes and enriched signaling pathways provides potential biomarkers for autoimmune thyroid dysfunction related to anti-CTLA-4 therapy and might contribute to the future diagnosis and management of IRAEs for cancer patients.
COVID-19 and digital disruption in UK universities: afflictions and affordances of emergency online migration
Authors: Watermeyer Richard , Crick Tom , Knight Cathryn , Goodall Janet 
Published: June 2020

AbstractCOVID-19 has caused the closure of university campuses around the world and migration of all learning, teaching, and assessment into online domains. The impacts of this on the academic community as frontline providers of higher education are profound. In this article, we report the findings from a survey ofn = 1148 academics working in universities in the United Kingdom (UK) and representing all the major disciplines and career hierarchy. Respondents report an abundance of what we call ‘afflictions’ exacted upon their role as educators and in far fewer yet no less visible ways ‘affordances’ derived from their rapid transition to online provision and early ‘entry-level’ use of digital pedagogies. Overall, they suggest that online migration is engendering significant dysfunctionality and disturbance to their pedagogical roles and their personal lives. They also signpost online migration as a major challenge for student recruitment, market sustainability, an academic labour-market, and local economies.
9-Acridinemethanamine and Acridine-9-Carboxaldehyde as Potential Fluorescence Lifetime pH Indicators
Authors: Totland Christian , Thomas Peter J. , Holst Bodil , Akhtar Naureen , Hovdenes Jostein , Skodvin Tore 
Published: June 2020

AbstractA significant challenge concerning the development of fluorescence lifetime (FL) based pH sensors is the paucity of fluorophores with sufficiently large FL variation with pH. Acridine is amongst the indicators with highest fluoresce lifetime responses to pH, with a change in lifetime of about 13 ns within a pH range of 5–8. Here we examine the two acridine derivatives, 9-acridinemethanamine (9-AMA) and acridine-9-carbaldehyde (9-ACA) in terms of their FL pH sensitivity and pH sensing range. Both indicators are characterized when dissolved in buffer solutions, as well as when immobilized in support materials. 9-AMA has a change in FL of 11 ns between pH 2–5, both when dissolved in solution and when immobilized in surfactant-filled mesoporous silica. The FL of 9-ACA is not sensitive to pH when dissolved in buffer solutions; however, when covalently bound to amine-modified silica, its FL changes 15 ns between pH 3–6. 9-AMA and 9-ACA represent promising FL in the pH range of pH 2–6, and could potentially form the basis of new FL pH sensors.
Ethical Considerations of Using Machine Learning for Decision Support in Occupational Health: An Example Involving Periodic Workers’ Health Assessments
Authors: Six Dijkstra Marianne W. M. C. , Siebrand Egbert , Dorrestijn Steven , Salomons Etto L. , Reneman Michiel F. , Oosterveld Frits G. J. , Soer Remko , Gross Douglas P. , Bieleman Hendrik J. 
Published: June 2020

AbstractPurposeComputer algorithms and Machine Learning (ML) will be integrated into clinical decision support within occupational health care. This will change the interaction between health care professionals and their clients, with unknown consequences. The aim of this study was to explore ethical considerations and potential consequences of using ML based decision support tools (DSTs) in the context of occupational health.MethodsWe conducted an ethical deliberation. This was supported by a narrative literature review of publications about ML and DSTs in occupational health and by an assessment of the potential impact of ML-DSTs according to frameworks from medical ethics and philosophy of technology. We introduce a hypothetical clinical scenario from a workers’ health assessment to reflect on biomedical ethical principles: respect for autonomy, beneficence, non-maleficence and justice.ResultsRespect for autonomy is affected by uncertainty about what future consequences the worker is consenting to as a result of the fluctuating nature of ML-DSTs and validity evidence used to inform the worker. A beneficent advisory process is influenced because the three elements of evidence based practice are affected through use of a ML-DST. The principle of non-maleficence is challenged by the balance between group-level benefits and individual harm, the vulnerability of the worker in the occupational context, and the possibility of function creep. Justice might be empowered when the ML-DST is valid, but profiling and discrimination are potential risks.ConclusionsImplications of ethical considerations have been described for the socially responsible design of ML-DSTs. Three recommendations were provided to minimize undesirable adverse effects of the development and implementation of ML-DSTs.
The Prangos genus: a comprehensive review on traditional use, phytochemistry, and pharmacological activities
Authors: Mottaghipisheh Javad , Kiss Tivadar , Tóth Barbara , Csupor Dezső 
Published: June 2020

AbstractThe members of the Prangos genus (Apiaceae) have been widely applied in the Iranian traditional medicine internally and externally for different purposes. The aim of this review is to summarize the ethnomedicinal and food applications of Prangos species and to gather the phytochemical and pharmacological data on this genus. Among the 129 constituents isolated from Prangos species, coumarin derivatives are the main compounds. Several papers report the compositions of essential oils obtained from different plant parts, mostly containing monoterpene and sesquiterpene hydrocarbons. Various pharmacological activities of essential oils, crude extracts or isolated compounds of the Prangos species have been observed, primarily in in vitro experiments. Antioxidant, antimicrobial, cytotoxic and anti-proliferative activities have been the most extensively studied. The efficacy and safety of Prangos plants have not been assessed in animal experiments or clinical trials. Although their furocoumarin content might be a source of adverse effects, toxic effects of Prangos species have not been reported. It can be concluded, that further preclinical and clinical data are necessary to assess the rationale and safety of the medicinal and food use of Prangos species.
An update of the Worldwide Integrated Assessment (WIA) on systemic pesticides. Part 4: Alternatives in major cropping systems
Authors: Veres Andrea , Wyckhuys Kris A. G. , Kiss Jozsef , Tóth Ferenc , Burgio Giovanni , Pons Xavier , Avilla Carlos , Vidal Stefan , Razinger Jaka , Bazok Renata , Matyjaszczyk Ewa , Milosavljević Ivan , Le Xuan Vi , Zhou Wenwu , Zhu Zeng-Rong , Tarno Hagus , Hadi Buyung , Lundgren Jonathan , Bonmatin Jean-Marc , van Lexmond Maarten Bijleveld , Aebi Alexandre , Rauf Aunu , Furlan Lorenzo 
Published: June 2020

AbstractWe present a synthetic review and expert consultation that assesses the actual risks posed by arthropod pests in four major crops, identifies targets for integrated pest management (IPM) in terms of cultivated land needing pest control and gauges the implementation “readiness” of non-chemical alternatives. Our assessment focuses on the world’s primary target pests for neonicotinoid-based management: western corn rootworm (WCR, Diabrotica virgifera virgifera) in maize; wireworms (Agriotes spp.) in maize and winter wheat; bird cherry-oat aphid (Rhopalosiphum padi) in winter wheat; brown planthopper (BPH, Nilaparvata lugens) in rice; cotton aphid (Aphis gossypii) and silver-leaf whitefly (SLW, Bemisia tabaci) in cotton. First, we queried scientific literature databases and consulted experts from different countries in Europe, North America, and Asia about available IPM tools for each crop-pest system. Next, using an online survey, we quantitatively assessed the economic relevance of target pests by compiling country-level records of crop damage, yield impacts, extent of insecticide usage, and “readiness” status of various pest management alternatives (i.e., research, plot-scale validation, grower-uptake). Biological control received considerable scientific attention, while agronomic strategies (e.g., crop rotation), insurance schemes, decision support systems (DSS), and innovative pesticide application modes were listed as key alternatives. Our study identifies opportunities to advance applied research, IPM technology validation, and grower education to halt or drastically reduce our over-reliance on systemic insecticides globally.
The Third Age: Reflections on Our Hidden Material Core
Authors: Škof Lenart 
Published: June 2020

AbstractThis paper deals with the concept of three eras, as brought to us firstly in the Babylonian Talmud, and later reshaped and reformulated by Christian theologians Joachim of Fiore, Amalric of Bène, and finally by Luce Irigaray. In the first part, we start with the idea of the three eras. This is followed by a critical approach to Sloterdijk’s You must change your life in which religion is substituted by the anthropotechnics. We argue that even in these secular times, the salvation history still remains unfulfilled and that our world is in need of a new, post-Christian materially spiritual narrative. The second part is entirely dedicated to Amalricians and their teachings. Also by tackling strong Islamic influences, we try to find a new opening towards the post-Christian era beyond the mentioned anthropotechnics/atheism divide. In the third part, the Age of the Spirit is approached and defined as a future messianic-utopian era in which a hidden and forgotten inner spiritual core will be revealed to us and in which humanity will give itself a gift of becoming spiritually transformed and divinized.
First-Line Management of Advanced High-Grade Serous Ovarian Cancer
Authors: Mahmood Reem D. , Morgan Robert D. , Edmondson Richard J. , Clamp Andrew R. , Jayson Gordon C. 
Published: June 2020

Abstract
Purpose of Review
Epithelial ovarian cancer is a disease that encompasses a number of histologically and molecularly distinct entities; the most prevalent subtype being high-grade serous (HGS) carcinoma. Standard first-line treatment of advanced HGS carcinoma includes cytoreductive surgery plus intravenous paclitaxel/platinum-based chemotherapy. Despite excellent responses to initial treatment, the majority of patients develop recurrent disease within 3 years. The introduction of the vascular endothelial growth factor (VEGF) inhibitor, bevacizumab, and poly(ADP-ribose) polymerase (PARP) inhibitors into first-line management has changed the outlook for this lethal disease. In this review, we summarise the most recent clinical trials that determine current primary therapy of advanced HGS carcinoma and the ongoing trials that aim to change management in the future.

Recent Findings
Recent phase III clinical trials have shown that delayed primary surgery after completing neo-adjuvant chemotherapy is non-inferior to immediate primary surgery, but could provide a survival benefit in FIGO (International Federation of Gynecology and Obstetrics) stage IV disease. The use of weekly intravenous chemotherapy regimens has not been proven to be more effective than standard 3-weekly regimens in Western patient populations, and the use of intraperitoneal chemotherapy remains controversial in the first-line setting. In contrast, newer systemic anti-cancer therapies targeting angiogenesis and/or HR-deficient tumours have been successfully incorporated into front-line therapeutic regimens to treat HGS carcinoma. Recent results from randomised trials investigating the use of PARP inhibitors as monotherapy and in combination with the anti-angiogenic agent, bevacizumab, have demonstrated highly impressive efficacy when combined with traditional first-line multi-modality therapy.

Summary
Management of HGS carcinoma is evolving, but further work is still required to optimise and integrate tumour and plasma biomarkers to exploit the potential of these highly efficacious targeted agents.
1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase
Authors: Sophocleous Georgios , Wood George , Owen Darerca , Mott Helen R. 
Published: June 2020

AbstractPRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like domain that targets it to the plasma membrane and a kinase domain, which is a member of the protein kinase C superfamily. PRK1 is involved in cytoskeletal regulation, cell adhesion, cell cycle progression and the immune response, and is implicated in cancer. There is currently no structural information for the HR1c domain. The1H,15N and13C NMR backbone and sidechain resonance assignment of the HR1c domain presented here forms the basis for this domain’s structural characterisation. This work will also enable studies of interactions between the three HR1 domains in an effort to obtain structural insight into the regulation of PRK1 activity.
Efficient estimation of hydraulic conductivity heterogeneity with non-redundant measurement information
Authors: Carrera Barbara , Mok Chin Man , Papaioannou Iason 
Published: June 2020

AbstractSolving the inverse problem of identifying groundwater model parameters with measurements is a computationally intensive task. Although model reduction methods provide computational relief, the performance of many inversion methods depends on the amount of often highly correlated measurements. We propose a measurement reduction method that only incorporates essential measurement information in the inversion process. The method decomposes the covariance matrix of the model output and projects both measurements and model response on the eigenvector space corresponding to the largest eigenvalues. We combine this measurement reduction technique with two inversion methods, the Iterated Extended Kalman Filter (IEKF) and the Sequential Monte Carlo (SMC) methods. The IEKF method linearizes the relationship between measurements and parameters, and the cost of the required gradient calculation increases with increase of the number of measurements. SMC is a Bayesian updating approach that samples the posterior distribution through sequentially sampling a set of intermediate measures and the number of sampling steps increases with increase of the information content. We propose modified versions of both algorithms that identify the underlying eigenspace and incorporate the reduced information content in the inversion process. The performance of the modified IEKF and SMC methods with measurement reduction is tested on a numerical example that illustrates the computational benefit of the proposed approach as compared to the standard IEKF and SMC methods with full measurement sets.
MusicMatic – The French Supreme Court’s Decision on Creative Commons Plus (CC+) Commercial Licensing and Mandatory Collective Management of the Right to Remuneration for Communication to the Public of Commercial Phonograms
Authors: Bulayenko Oleksandr 
Published: June 2020

AbstractThe French Supreme Court established that businesses using on their premises devices provided by third parties for making background music are performing an act of communication to the public in the sense of Art. L214-1 of the French Intellectual Property Code (CPI). The Court qualified commercially licensed phonograms, also published under Creative Commons non-commercial licences (CC BY-NC-ND 3.0) on the Jamendo online platform, as “phonograms published for commercial purposes”. According to the Court, the right to remuneration for communication to the public of phonograms published for commercial purposes cannot be contractually waived by performers. The right to remuneration is subject to mandatory management by a collective management organisation (CMO) regardless of whether rightholders have explicitly contractually entrusted the exercise of their rights to the CMO. Mandatory collective management of the right to remuneration for communication to the public of phonograms published for commercial purposes is compatible with EU law. The Supreme Court declined to refer the question of the compatibility of mandatory collective management to the Court of Justice of the European Union (CJEU), considering that the law is sufficiently clear in this regard.
Estimation of socioeconomic attributes from location information
Authors: Doi Shohei , Mizuno Takayuki , Fujiwara Naoya 
Published: June 2020

AbstractTimely estimation of the distribution of socioeconomic attributes and their movement is crucial for academic as well as administrative and marketing purposes. In this study, assuming personal attributes affect human behavior and movement, we predict these attributes from location information. First, we predict the socioeconomic characteristics of individuals by supervised learning methods, i.e., logistic Lasso regression, Gaussian Naive Bayes, random forest, XGBoost, LightGBM, and support vector machine, using survey data we collected of personal attributes and frequency of visits to specific facilities, to test our conjecture. We find that gender, a crucial attribute, is as highly predictable from locations as from other sources such as social networking services, as done by existing studies. Second, we apply the model trained with the survey data to actual GPS log data to check the performance of our approach in a real-world setting. Though our approach does not perform as well as for the survey data, the results suggest that we can infer gender from a GPS log.
Reproduktive Freiheit für wen?
Authors: Beck Birgit 
Published: June 2020

ZusammenfassungDer vorliegende Kommentar wirft, nach einer knappen Zusammenfassung der Argumentation des Beitrags von Tatjana Tarkian, einige grundsätzliche Fragen auf, welche die Geltungsreichweite und Anwendbarkeit der Prinzipien der reproduktiven Autonomie und der wohltätigen Fortpflanzung betreffen. Welche prospektiven Eltern sind Adressat*innen der Prinzipien der reproduktiven Freiheit und der wohltätigen Fortpflanzung? Stellen diese Prinzipien universell und überzeitlich gültige allgemeine Prinzipien dar, die generell in jeder Situation reproduktiver Entscheidung Berücksichtigung finden sollten? Lassen sie sich nur unter der Voraussetzung bestimmter Bedingungen bzw. im Rahmen bestimmter Kontexte anwenden? Sind die beiden Prinzipien kompatibel oder widersprechen sie sich? Kommt prospektiven Eltern eine moralische Verantwortung für die Umsetzbarkeit ihrer reproduktiven Freiheit zu?