bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of Highly Polarized Organometallic Compounds to N‐tert‐Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest
Authors: Cicco Luciana , Salomone Antonio , Vitale Paola , Ríos‐Lombardía Nicolás , González‐Sabín Javier , García‐Álvarez Joaquín , Perna Filippo M. , Capriati Vito 
Published: May 2020

AbstractHighly polarized organometallic compounds of s‐block elements are added smoothly to chiral N‐tert‐butanesulfinyl imines in the biodegradable d‐sorbitol/choline chloride eutectic mixture, thereby granting access to enantioenriched primary amines after quantitatively removing the sulfinyl group. The practicality of the method is further highlighted by proceeding at ambient temperature and under air, with very short reaction times (2 min), enabling the preparation of diastereoisomeric sulfinamides in very good yields (74–98 %) and with a broad substrate scope, and the possibility of scaling up the process. The method is demonstrated in the asymmetric syntheses of both the chiral amine side‐chain of (R,R)‐Formoterol (96 % ee) and the pharmaceutically relevant (R)‐Cinacalcet (98 % ee).
Prenatal maternal C‐reactive protein prospectively predicts child executive functioning at ages 4–6 years
Authors: Morgan Julia E. , Lee Steve S. , Mahrer Nicole E. , Guardino Christine M. , Davis Elysia Poggi , Shalowitz Madeleine U. , Ramey Sharon L. , Dunkel Schetter Christine 
Published: May 2020

AbstractThis prospective longitudinal study evaluated multiple maternal biomarkers from the preconception and prenatal periods as time‐sensitive predictors of child executive functioning (EF) in 100 mother–child dyads. Maternal glycated hemoglobin (HbA1C), C‐reactive protein (CRP), and blood pressure (BP) were assayed before pregnancy and during the second and third trimesters. Subsequently, children were followed from birth and assessed for EF (i.e. cognitive flexibility, response inhibition) at ages 4–6 years. Perinatal data were also extracted from neonatal records. Higher maternal CRP, but not maternal HbA1C or BP, uniquely predicted poorer child cognitive flexibility, even with control of maternal HbA1C and BP, relevant demographic factors, and multiple prenatal/perinatal covariates (i.e. preconception maternal body mass index, maternal depression, maternal age at birth, child birth weight, child birth order, child gestational age, and child birth/neonatal complications). Predictions from maternal CRP were specific to the third trimester, and third trimester maternal CRP robustly predicted child cognitive flexibility independently of preconception and second trimester CRP. Child response inhibition was unrelated to maternal biomarkers from all time points. These findings provide novel, prospective evidence that maternal inflammation uniquely predicts child cognitive flexibility deficits, and that these associations depend on the timing of exposure before or during pregnancy.
A performance score of the quality of inpatient diabetes care is a marker of clinical outcomes and suggests a cause‐effect relationship between hypoglycaemia and the risk of in‐hospital mortality
Authors: Dei Cas Alessandra , Aldigeri Raffaella , Ridolfi Valentina , Vazzana Angela , Ciardullo Anna Vittoria , Manicardi Valeria , Sforza Alessandra , Tomasi Franco , Zavaroni Donatella , Zavaroni Ivana , Bonadonna Riccardo C. 
Published: May 2020

AbstractAimsTo build a tool to assess the management of inpatients with diabetes mellitus and to investigate its relationship, if any, with clinical outcomes.Materials and methodsA total of 678 patients from different settings, Internal Medicine (IMU, n = 255), General Surgery (GSU, n = 230) and Intensive Care (ICU, n = 193) Units, were enrolled. A work‐flow of clinical care of diabetes was created according to guidelines. The workflow was divided into five different domains: (a) initial assessment; (b) glucose monitoring; (c) medical therapy; (d) consultancies; (e) discharge. Each domain was assessed by a performance score (PS), computed as the sum of the scores achieved in a set of indicators of clinical appropriateness, management and patient empowerment. Appropriate glucose goals were included as intermediate phenotypes. Clinical outcomes included: hypoglycaemia, survival rate and clinical conditions at discharge.ResultsThe total PS and those of initial assessment and glucose monitoring were significantly lower in GSU with respect to IMU and ICU (P < .0001). The glucose monitoring PS was associated with lower risk of hypoglycaemia (OR = 0.55; P < .0001), whereas both the PSs of glucose monitoring and medical therapy resulted associated with higher in‐hospital survival only in the IMU ward (OR = 6.67 P = .001 and OR = 2.38 P = .03, respectively). Instrumental variable analysis with the aid of PS of glucose monitoring showed that hypoglycaemia may play a causal role in in‐hospital mortality (P = .04).ConclusionsThe quality of in‐hospital care of diabetes may affect patient outcomes, including glucose control and the risk of hypoglycaemia, and through the latter it may influence the risk of in‐hospital mortality.
Improving blood glucose level predictability using machine learning
Authors: Marcus Yonit , Eldor Roy , Yaron Mariana , Shaklai Sigal , Ish‐Shalom Maya , Shefer Gabi , Stern Naftali , Golan Nehor , Dvir Amit Z. , Pele Ofir , Gonen Mira 
Published: May 2020

AbstractThis study was designed to improve blood glucose level predictability and future hypoglycemic and hyperglycemic event alerts through a novel patient‐specific supervised‐machine‐learning (SML) analysis of glucose level based on a continuous‐glucose‐monitoring system (CGM) that needs no human intervention, and minimises false‐positive alerts. The CGM data over 7 to 50 non‐consecutive days from 11 type‐1 diabetic patients aged 18 to 39 with a mean HbA1C of 7.5% ± 1.2% were analysed using four SML models. The algorithm was constructed to choose the best‐fit model for each patient. Several statistical parameters were calculated to aggregate the magnitudes of the prediction errors. The personalised solutions provided by the algorithm were effective in predicting glucose levels 30 minutes after the last measurement. The average root‐mean‐square‐error was 20.48 mg/dL and the average absolute‐mean‐error was 15.36 mg/dL when the best‐fit model was selected for each patient. Using the best‐fit‐model, the true‐positive‐hypoglycemia‐prediction‐rate was 64%, whereas the false‐positive‐ rate was 4.0%, and the false‐negative‐rate was 0.015%. Similar results were found even when only CGM samples below 70 were considered. The true‐positive‐hyperglycemia‐prediction‐rate was 61%. State‐of‐the‐art SML tools are effective in predicting the glucose level values of patients with type‐1diabetes and notifying these patients of future hypoglycemic and hyperglycemic events, thus improving glycemic control. The algorithm can be used to improve the calculation of the basal insulin rate and bolus insulin, and suitable for a closed loop “artificial pancreas” system. The algorithm provides a personalised medical solution that can successfully identify the best‐fit method for each patient.
Assessing congruence of opportunistic records and systematic surveys for predicting Hispaniolan mammal species distributions
Authors: Turvey Samuel T. , Kennerley Rosalind J. , Hudson Michael A. , Nuñez‐Miño Jose M. , Young Richard P. 
Published: May 2020

AbstractComparative assessment of the relative information content of different independent spatial data types is necessary to evaluate whether they provide congruent biogeographic signals for predicting species ranges. Opportunistic occurrence records and systematically collected survey data are available from the Dominican Republic for Hispaniola’s surviving endemic non‐volant mammals, the Hispaniolan solenodon (Solenodon paradoxus) and Hispaniolan hutia (Plagiodontia aedium); opportunistic records (archaeological, historical and recent) exist from across the entire country, and systematic survey data have been collected from seven protected areas. Species distribution models were developed in maxent for solenodons and hutias using both data types, with species habitat suitability and potential country‐level distribution predicted using seven biotic and abiotic environmental variables. Three different models were produced and compared for each species: (a) opportunistic model, with starting model incorporating abiotic‐only predictors; (b) total survey model, with starting model incorporating biotic and abiotic predictors; and (c) reduced survey model, with starting model incorporating abiotic‐only predictors to allow further comparison with the opportunistic model. All models predict suitable environmental conditions for both solenodons and hutias across a broadly congruent, relatively large area of the Dominican Republic, providing a spatial baseline of conservation‐priority landscapes that might support native mammals. Correlation between total and reduced survey models is high for both species, indicating the substantial explanatory power of abiotic variables for predicting Hispaniolan mammal distributions. However, correlation between survey models and opportunistic models is only moderately positive. Species distribution models derived from different data types can provide different predictions about habitat suitability and conservation‐priority landscapes for threatened species, likely reflecting incompleteness and bias in spatial sampling associated with both data types. Models derived using both opportunistic and systematic data must therefore be applied critically and cautiously.
A nucleation framework for transition between alternate states: short‐circuiting barriers to ecosystem recovery
Authors: Michaels Theo K. , Eppinga Maarten B. , Bever James D. 
Published: May 2020

AbstractThe theory of alternate stable states provides an explanation for rapid ecosystem degradation, yielding important implications for ecosystem conservation and restoration. However, utilizing this theory to initiate transitions from degraded to desired ecosystem states remains a significant challenge. Applications of the alternative stable states framework may currently be impeded by a mismatch between local‐scale driving processes and landscape‐scale emergent system transitions. We show how nucleation theory provides an elegant bridge between local‐scale positive feedback mechanisms and landscape‐scale transitions between alternate stable ecosystem states. Geometrical principles can be used to derive a critical patch radius: a spatially explicit, local description of an unstable equilibrium point. This insight can be used to derive an optimal patch size that minimizes the cost of restoration, and to provide a framework to measure the resilience of desired ecosystem states to the synergistic effects of disturbance and environmental change.
Estimation method of photovoltaic power output using extended Lambert‐Beer law
Authors: Odashima Jun , Shinoda Yukio , Takeda Hisashi 
Published: May 2020

AbstractIn recent years, there have been growing needs for accurate estimation of photovoltaic (PV) power due to the widespread use of PV power generation. PV power is usually estimated based on the amount of solar radiation, air temperature, and wind velocity. However, when the PV panel is covered with snow, the solar radiation is blocked by the snow and expected PV output cannot be obtained. In this paper, for accurate PV power estimation, we propose an Extended Lambert‐Beer law, and investigate a method to estimate the degree of attenuation of PV power by snow cover. And, accuracy verification of the proposed method is carried out with actual PV power records from when snow accumulated in the Tokyo Electric Power Company (TEPCO) service area in 2018.
The pharmacokinetics, efficacy, and safety of a novel selective‐dose cannabis inhaler in patients with chronic pain: A randomized, double‐blinded, placebo‐controlled trial
Authors: Almog Shlomo , Aharon‐Peretz Judith , Vulfsons Simon , Ogintz Miri , Abalia Hadas , Lupo Tal , Hayon Yael , Eisenberg Elon 
Published: May 2020

AbstractBackgroundPrecise cannabis treatment dosing remains a major challenge, leading to physicians’ reluctance to prescribe medical cannabis.ObjectiveTo test the pharmacokinetics, analgesic effect, cognitive performance and safety effects of an innovative medical device that enables the delivery of inhaled therapeutic doses of Δ9‐Tetrahydrocannabinol (THC) in patients with chronic pain.MethodsIn a randomized, three‐arms, double‐blinded, placebo‐controlled, cross‐over trial, 27 patients received a single inhalation of Δ9‐THC: 0.5mg, 1mg, or a placebo.Δ9‐THC plasma levels were measured at baseline and up to 150‐min post‐inhalation. Pain intensity and safety parameters were recorded on a 10‐cm visual analogue scale (VAS) at pre‐defined time points. The cognitive performance was evaluated using the selective sub‐tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsFollowing inhalation of 0.5 mg or 1mg, Δ9‐THC plasma Cmax ± SD were 14.3 ± 7.7 and 33.8 ± 25.7 ng/ml. Tmax ± SD were 3.7 ± 1.4 and 4.4 ± 2.1 min, and AUC0 → infinity±SD were 300 ± 144 and 769 ± 331 ng*min/ml, respectively. Both doses, but not the placebo, demonstrated a significant reduction in pain intensity compared with baseline and remained stable for 150‐min. The 1‐mg dose showed a significant pain decrease compared to the placebo. Adverse events were mostly mild and resolved spontaneously. There was no evidence of consistent impairments in cognitive performance.ConclusionThis feasibility trial demonstrated that a metered‐dose cannabis inhaler delivered precise and low THC doses, produced a dose‐dependent and safe analgesic effect in patients with neuropathic pain/ complex‐regional pain syndrome (CRPS). Thus, it enables individualization of medical cannabis regimens that can be evaluated pharmacokinetically and pharmacodynamically by accepted pharmaceutical models.SignificanceEvidence suggests that cannabis‐based medicines are an effective treatment for chronic pain in adults. The pharmacokinetics of THC varies as a function of its route of administration. Pulmonary assimilation of inhaled THC causes rapid onset of analgesia. However, currently used routes of cannabinoids delivery provide unknown doses, making it impossible to implement a pharmaceutical standard treatment plan. A novel selective‐dose cannabis inhaler delivers significantly low and precise doses of THC, thus allowing the administration of inhaled cannabis‐based medicines according to high pharmaceutical standards. These low doses of THC can produce safe and effective analgesia in patients with chronic pain.
Alterations in SUMOylation of the hyperpolarization‐activated cyclic nucleotide‐gated ion channel 2 during persistent inflammation
Authors: Forster Lori A. , Jansen Leslie‐Anne R. , Rubaharan Myurajan , Murphy Anne Z. , Baro Deborah J. 
Published: May 2020

AbstractBackgroundUnilateral injection of Complete Freund's Adjuvant (CFA) into the intra‐plantar surface of the rodent hindpaw elicits chronic inflammation and hyperalgesia in the ipsilateral hindlimb. Mechanisms contributing to this hyperalgesia may act over multiple time courses and can include changes in ion channel expression and post‐translational SUMOylation. Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels mediate the hyperpolarization‐activated current, Ih. An HCN2‐mediated increase in C‐nociceptor Ih contributes to mechanical hyperalgesia in the CFA model of inflammatory pain. Changes in HCN2 post‐translational SUMOylation and protein expression have not been systematically documented for a given dorsal root ganglia (DRG) throughout the time course of inflammation.MethodsThis study examined HCN2 protein expression and post‐translational SUMOylation in a rat model of CFA‐induced hindpaw inflammation. L5 DRG cryosections were used in immunohistochemistry experiments and proximity ligation assays to investigate HCN2 expression and SUMOylation, respectively, on days 1 and 3 post‐CFA.ResultsUnilateral CFA injection elicited a significant bilateral increase in HCN2 staining intensity in small diameter DRG neurons on day 1 post‐CFA, and a significant bilateral increase in the number of small neurons expressing HCN2 but not staining intensity on day 3 post‐CFA. HCN2 channels were hyper‐SUMOylated in small diameter neurons of ipsilateral relative to contralateral DRG on days 1 and 3 post‐CFA.ConclusionsUnilateral CFA injection elicits unilateral mechanical hyperalgesia, a bilateral increase in HCN2 expression and a unilateral increase in post‐translational SUMOylation. This suggests that enhanced HCN2 expression in L5 DRG is not sufficient for mechanical hyperalgesia in the early stages of inflammation and that hyper‐SUMOylation of HCN2 channels may also be necessary.SignificanceNociceptor HCN2 channels mediate an increase in Ih that is necessary for mechanical hyperalgesia in a CFA model of chronic pain, but the mechanisms producing the increase in nociceptor Ih have not been resolved. The data presented here suggest that the increase in Ih during the early stages of inflammation may be mediated by an increase in HCN2 protein expression and post‐translational SUMOylation.
Colorblind and multicultural diversity strategies create identity management pressure
Authors: Kirby Teri A. , Silva Rego Marco , Kaiser Cheryl R. 
Published: May 2020

AbstractColorblind and multicultural diversity strategies may create identity management pressure, leading minorities to assert or distance from their racial identity. In two experiments (N = 307, 279), Asian and Asian American participants in the United States completed racial identification measures, contemplated employment at a company expressing a multicultural, colorblind, or control strategy, and completed measures assessing ingroup similarity and comfort in the company. In the colorblind condition, participants who were strongly identified with their racial ingroup downplayed similarity to the ingroup and expressed less comfort relative to multicultural and control conditions. Participants who were weakly identified reported more similarity (but inconsistently) and more comfort in the colorblind relative to multicultural and control conditions. Thus, diversity strategies convey different meanings to strongly and weakly identified Asian individuals, with the former responding to colorblindness with identity distancing and the latter with identity assertion. Multiculturalism does not alter the typical pattern expected, with strongly identified asserting their identity more than weakly identified.
Cross-Taxa Distinctions in Mechanisms of Developmental Effects for Aquatic Species Exposed to Trifluralin
Authors: Awkerman Jill A. , Lavelle Candice M. , Henderson W. Matthew , Hemmer Becky L. , Lilavois Crystal R. , Harris Peggy , Zielinski Nick , Hoglund Marilynn D. , Glinski Donna A. , MacMillan Denise , Ford Jermaine , Seim Roland F. , Moso Elizabeth , Raimondo Sandy 
Published: May 2020

Abstract
Standard ecological risk assessment practices often rely on larval and juvenile fish toxicity data as representative of the amphibian aquatic phase. Empirical evidence suggests that endpoints measured in fish early life stage tests are often sufficient to protect larval amphibians. However, the process of amphibian metamorphosis relies on endocrine cues that affect development and morphological restructuring and are not represented by these test endpoints. The present study compares developmental endpoints for zebrafish (Danio rerio) and the African clawed frog (Xenopus laevis), 2 standard test species, exposed to the herbicide trifluralin throughout the larval period. Danio rerio were more sensitive and demonstrated a reduction in growth measurements with increasing trifluralin exposure. Size of X. laevis at metamorphosis was not correlated with exposure concentration; however, time to metamorphosis was delayed relative to trifluralin concentration. Gene expression patterns indicate discrepancies in response by D. rerio and X. laevis, and dose-dependent metabolic activity suggests that trifluralin exposure perturbed biological pathways differently within the 2 species. Although many metabolites were correlated with exposure concentration in D. rerio, nontargeted hepatic metabolomics identified a subset of metabolites that exhibited a nonmonotonic response to trifluralin exposure in X. laevis. Linking taxonomic distinctions in cellular-level response with ecologically relevant endpoints will refine assumptions used in interspecies extrapolation of standard test effects and improve assessment of sublethal impacts on amphibian populations. Environ Toxicol Chem 2020;39:1797–1812. Published 2020. This article is a US government work and is in the public domain in the USA.
Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan of Caenorhabditis elegans
Authors: Liu Jie , Wang Huailing , Liu Xiaoyu , Zhang Guohao , Liu Zhigang 
Published: May 2020

AbstractChinese liquor is obtained from various grains by fermentation and complex processes. Chinese liquor contains complex ingredients. However, the low contents and presence of ethanol restricted the flavor substances function study. In current study, a flavor substance, homofuraneol (HOMO) was isolated from the Chinese liquor and the potency against H2O2‐induced oxidative damage in HepG2 cells and lifespan‐extending ability in Caenorhabditis elegans were explored. Results indicated that HOMO increased the HepG2 cells cytoactive by eliminating excessive intracellular free radicals, upregulating antioxidant enzyme activity and inhibiting the phosphorylation of mitogen‐activated protein kinases (MAPKs) pathway. Further study revealed that HOMO extended the lifespan of N2 nematodes under normal and oxidative stress conditions. Moreover, RT‐PCR results showed that paraquat activated the expression of PMK‐1 and SKN‐1 was significantly regulated by HOMO. Of note, our results indicated that HOMO recovered the redox states of HepG2 cells by targeting MAPKs and upregulating the stress resistance of nematodes by modulating the expression of stress‐responsive genes, such as DAF‐16.