bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thoracic vertebral metastasis from progressive hepatocellular carcinoma following liver transplantation combined with resection of mesenteric and colonic metastases
Authors: Hu Jingen , Hu Caibao 
Published: October 2020

Abstract

Rationale:
Surgical treatment of spinal hepatocellular carcinoma metastasis after Liver transplantation (LT) is a clinical challenge. We herein report the clinical outcomes of the first case of a patient with T11 from hepatocellular carcinoma metastasis after systemic chemotherapy following LT combined with mesenteric resection and colectomy, who was successfully treated with En Bloc spondylectomy.

Patient concerns:
The patient with HCC was a 40-year-old man, who had received LT combined with mesenteric resection and colectomy 15 months before. His main symptom was progressive back pain because of T11 metastasis. PET examinations showed a solitary metastasis at T11 without recurrence in the liver and metastasis in the other organs.

Diagnosis:
The patient was diagnosed with the T11 vertebra HCC metastasis after LT combined with resection of HCC mesenteric metastasis and colon metastasis.

Interventions:
Five cycles of systemic chemotherapy following LT were performed for preventing HCC metastases. However, the right abdominal wall metastasis was found 9 months after LT, followed by T11 metastases thereafter. Immediate resection of the right abdominal wall metastasis was achieved. En Bloc spondylectomy of T11 vertebra was chosen as a treatment for metastasis to T11. After T11 surgery, the patient showed obvious pain relief. However, At 3 months after T11 surgery, a grafted liver metastasis and multiple nodules metastasis in the greater omentum region were revealed with CT imaging, At 5 months after T11 surgery, multiple lung metastases were discovered by MRI. The patient was performed 5 cycles of chemotherapy, 3 times of infusion of iodine [131I] meximab and 3 times of TACE after T11 surgery. Multiple bone metastases were treated with radiotherapy.

Outcomes:
The patient died 29 months after LT combined with mesenteric resection and colectomy because of recurrence in the liver and metastasis in the lung.

Lessons:
En Bloc spondylectomy may be a therapeutic choice for patients with progression after systemic chemotherapy for the solitary spinal metastases after LT combined with mesenteric resection and colectomy, which has a survival benefit without local recurrence at the surgical site. immunosuppressant after LT may result in worse immune function, which leads to HCC more prone to recurrence and bone metastasis.
Effect of herbal medicine Shenghua decoction on uterine bleeding after early medical abortion
Authors: Cheng Ran , Liu Shuhua , Gu Jianghong , Xu Lvyan 
Published: October 2020

Abstract

Background:
Excessive and prolonged uterine bleeding is an important obstacle for medical abortion to get popularized. Shenghua decoction (SHD) is widely used for treating uterine bleeding after early medical abortion. However, the clinical evidence is unclear.

Methods:
Two researchers will dependently search literatures of SHD for the treatment of uterine bleeding after medical abortion from Web of Science, PubMed, Embase, and The Cochrane Library; traditional Chinese medicine databases; China National Knowledge Infrastructure (CNKI); Chinese Scientific Journal Database (VIP database); and Wan-Fang Database. These inclusive data of included studies will be conducted by RevMan V5.3 software.

Results:
This systematic review and meta-analysis will provide a detailed summary of the current evidence related to the efficacy of SHD in treating uterine bleeding after early medical abortion, including the duration and volume of uterine bleeding, the medical abortion pain.

Conclusion:
This systematic review and meta-analysis will provide a detailed summary of the current evidence related to the efficacy of SHD in treating uterine bleeding after early medical abortion,

Registration Number:
PROSPERO CRD42020184465.
Effect of phenotypic detection of circulating tumor cells marked by epithelial-mesenchymal transformation on the prognosis of lung cancer
Authors: Ge Bin , Wang Yong , Lei Shaoqing , Zhang Jincao 
Published: October 2020

Abstract

Background:
To explore the significance of phenotype detection of circulating tumor cells (CTCs) based on epithelial-mesenchymal transition (EMT) labeling to evaluate the prognosis of lung cancer.

Methods:
Database was retrieved from China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database, PubMed, and EMBASE. Based on EMT on overall survival (OS) and disease-free survival (DFS), hazard ratios (HRs) and its 95% of confidence intervals (CIs) were applied to assess the prognostic effect of CTCs. RevMan 5.3 and STATA 16.0 software were adopted to perform the meta-analysis.

Results:
Based on EMT in terms of the prognosis of patients suffering from lung cancer, this study comprehensively reviewed and evaluated the available evidence of phenotype detection of CTCs.

Conclusion:
Based on EMT in the prognosis of patients who developed with lung cancer, our findings proved the effect of phenotype detection of CTCs. Such studies may reveal a new prognostic marker for lung cancer patients and help clinicians and health professionals make clinical decisions.

OSF Registration Number:
DOI 10.17605/OSF.IO/E7KAZ.
Efficacy of radial extracorporeal shock wave therapy for chronic prostatitis/chronic pelvic pain syndrome
Authors: Li Guangsen , Chang Degui , Chen Di’ang , Zhang Peihai , You Yaodong , Huang Xiaopeng , Cai Jian , Yang Xuesong 
Published: October 2020

Abstract

Background:
Prostatitis is a common urogenital system disease in men which affects 5% to 9% of adult men worldwide and accounts for approximately 8% of visits to urologists. In the past years, its pathogenesis is complicated and the classification of it is not clear, so the effect of treatment measures is not significant. Recently, the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) includes nonsteroidal anti-inflammatory drugs, phytotherapy, hormonal therapy, alpha-blockers, anti-anxiolytic, and acupuncture, which provide more choice for the urologist. But there still are some limitations. scholars. Many studies suggest radial extracorporeal shock wave therapy may be the better option in the treatment of CP/CPPS. However, the efficacy and safety of it still lack solid evidence.

Methods and analysis:
The electronic databases of MEDLINE, PubMed, Web of Science, EMBASE, Cochrane Library, Clinicaltrials.org, China National Knowledge Infrastructure Database, Wan fang Database, China Biology Medicine Database, VIP Science Technology Periodical Database, Chinese Clinical Trial Registry will be retrieved. All the randomized controlled trials of radial extracorporeal shock wave therapy (rESWT) for patients with CP/CPPS will be included. We will evaluate the outcomes including National Institutes of Health Chronic Prostatitis Symptom Index, visual analog scale, international prostate symptom score, international index of erectile function-5, and conduct this study strictly according to the Cochrane Handbook for Systematic Reviews of Interventions.

Results:
The current study is a protocol for systematic review and meta-analysis without results, and data analysis will be carried out after the protocol. We will share our findings on October 31st of 2021.

Conclusion:
rESWT as a noninvasive treatment with no pain, which will be accepted more easily. Although some studies have suggested that rESWT can relieve the symptoms of patients, the efficacy and safety of it still lack solid evidence. To address this limitation scientifically and systematically, this study will inspect the efficacy and safety of the rESWT treatment in patients with CP/CPPS by integrating various studies.

Ethics and dissemination:
Formal ethical approval is not required in this protocol. We will collect and analyze data based on published studies, and since there are no patients involved in this study, individual privacy will not be under concerns. The results of this review will be disseminated to peer-reviewed journals or submit to related conferences.

Protocol registration number:
INPLASY202090076
Treatment of atypical gouty arthritis of the hip using total hip arthroplasty
Authors: Huang Yuyang , Huang Jiongfeng , Luo Cheng , Chen Li’an , Huang Bingsheng 
Published: October 2020

Abstract

Rationale:
Gout and gouty arthritis typically involve peripheral and monoarticular joints, especially the first metatarsophalangeal joint and knees. Hip involvement in patients with gout is rare, and its diagnosis is very difficult, especially in the late stages of the disease. Total hip arthroplasty could be a surgical treatment for atypical gouty arthritis of the hip; however, few cases have been reported.

Patient concerns:
We reported an uncommon case of a 74-year-old man without typical symptoms of hip gout arthritis whom was misdiagnosed as having avascular necrosis of the femoral head.

Diagnoses:
Clinical examination and imaging revealed bilateral avascular necrosis of the femoral head. However, the final pathology report revealed left hip gout arthritis.

Interventions:
The patient underwent left total hip arthroplasty and was followed up for 3years.

Outcomes:
The outcome was favorable. The function of the left hip was almost normal.

Lessons:
Our case indicated the difficulty of the diagnosis of hip gout arthritis. Due to the lower rates of hip gout arthritis and lack of typical clinical examination, it is easy to misdiagnose. Furthermore, surgical treatment for the late stage of hip gout arthritis has not previously been reported. In our case, total hip arthroplasty proved to be a good option.
Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma
Authors: Hu Tianhao , Wang Run , Song Yifu , Yu Juanhan , Guo Zongze , Han Sheng 
Published: October 2020

Abstract

Rationale:
Tumor-to-tumor metastasis is a rare clinical phenomenon. Although meningioma is the most common intracranial recipient of cancer metastasis, only a few cases have been reported. We present a case of metastasis of lung adenocarcinoma into intracranial meningioma and review the published literature.

Patient concerns:
A 70-year-old woman was admitted to our hospital for a 1-month history of headache and pain in her lower extremities.

Diagnosis:
Brain and lumbar vertebral magnetic resonance imaging showed an intracranial space-occupying lesion in the right occipital region and spinal canal stenosis. Pulmonary computed tomography showed an irregular mass in the right upper lobe of the lung. The postoperative histological examination demonstrated adenocarcinoma metastasis to meningioma.

Intervention:
The patient underwent right occipital craniotomy for tumor removal and lumbar spinal canal decompression.

Outcomes:
There were no initial abnormal conditions after the operation. However, the patient died suddenly 7 days after surgery.

Lessons:
Tumor-to-meningioma metastasis is a rare but important phenomenon. According to previous reports, it is associated with rapid onset of symptoms and a poor prognosis. Histological examination is of great importance in diagnosis. The history and process of malignant carcinoma should be closely monitored.
Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation
Authors: Hu Lianbo , Zheng Bingrong , Fu Lijuan , Hu Meiwei 
Published: October 2020

Abstract

Rationale:
Extramedullary invasion of chronic myelomonocytic leukemia (CMML) usually occurs in the liver, spleen, and lymph nodes, while the pleural infiltration of CMML is rare. The presence of pleural effusion is usually associated with uncontrolled leukocytosis and increased monocytes.

Patient concerns:
Here we reported a rare case of CMML-0 with pleural effusion as the first manifestation in a 44-year-old woman. The pleural effusion was caused by blasts infiltration confirmed by the flow cytometer and the pleural biopsy.

Diagnoses:
CMML with pleural invasion.

Interventions:
The patient was treated with azacitidine 75 mg/m2 d for 2 cycles, followed by daily oral intake of hydroxyurea (500 mg/d).

Outcomes:
Pleural effusion was resolved and chest pain was relieved.

Lessons:
The current case indicated that leukemic infiltration into pleura could occur despite mild leukocytes, while demethylation may be an effective therapy.
Auricular acupuncture for migraine
Authors: Chen Yuqin , Liu Bingyang , Gong Weina , Liu Guoqiang 
Published: October 2020

Abstract

Introduction:
Migraines are caused by neurological and vascular dysfunction, with a side or both sides of the head pain recurrent attack, often accompanied by nausea, vomiting, light, and sound allergy as the characteristics, is the clinical common disease, frequently occurring disease. The incidence of migraine is 8.4% to 28% worldwide (highest in Germany), and the lifetime incidence is about 14.0%. About 18.2% for women and 6.5% for men, About 23 percent of families have at least one migraine sufferer.
[1]
It can occur at any age, and more than half of patients have headaches that interfere with work or school, while nearly a third may miss work or school because of the headache.
[2]
Therefore, how to relief headache immediately and reduce the impact on life and work, becomes the basic clinical appeal of many patients. Analgesics are the main treatment for migraine in western medicine, many patients, who worried about the side effects of drugs, often take them only when the pain is unbearable, which can only treat the symptoms rather than the root causes.
[3]
Auricular acupuncture as a form of acupuncture therapy which is proved to be effective in RCTs and very suitable for patients, has been used in patients who suffer from migraine for a long time, therefore a systematic review is necessary to provide available evidence for further study.

Methods and analysis:
The following databases will be searched from their inception to September 2020: Electronic database includes PubMed, Embase, Cochrane Library, Web of Science, Nature, Science online, VIP medicine information, and CNKI (China National Knowledge Infrastructure). Primary outcomes: Score of migraine symptoms. Additional outcomes: The overall effective rate. Data will be extracted by two researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0.

Results:
The results of this study will systematically evaluate the effectiveness and safety of auricular acupuncture intervention for people with migraine.

Conclusion:
The systematic review of this study will summarize the current published evidence of auricular acupuncture for the treatment of migraine, which can further guide the promotion and application of it.

Ethics and dissemination:
This study is a systematic review, the outcomes are based on the published evidence, so examination and agreement by the ethics committee are not required in this study. We intend to publish the study results in a journal or conference presentations.

Open Science Fra network (OSF) registration number:
October 2, 2020 osf.io/q6arf. (https://osf.io/q6arf/.)
Global Status in Chronic Pancreatitis Research
Authors: Yang Huai-Yu , Wang Dan , Liu Yu , Han Chao , Xin Lei , Li Zhao-Shen , Liao Zhuan , Hu Liang-Hao 
Published: October 2020

Objective
The aim of the study was to investigate the global research levels in chronic pancreatitis (CP) fields.

Methods
The term “chronic pancreatitis” was used to retrieve articles published between 2009 and 2018 from the Web of Science database. The 15 highest-output countries' gross domestic product was retrieved to analyze the correlation between output and economic development. The 5 top-ranking countries were compared in quantity and quality. The frequently used terms of all articles were retrieved to conduct co-occurrence analysis to reveal research highlights for CP.

Results
There were 6094 articles included and 6007 articles were from 15 highest-output countries. There was a positive correlation between output and gross domestic product (r = 0.928, P < 0.001). The United States, China, and Japan had increasing trends in total output (P = 0.022, P < 0.001, and P = 0.021, respectively). China and Japan had increasing trends in output per capita (P < 0.001 and P = 0.023). However, in average impact factor, all 5 countries did not show increasing trends (all P > 0.05). For research highlights, mass lesion and autoimmune pancreatitis were the notable aspects.

Conclusions
The global output for CP will continue increasing and research quality will be stable.
Effects of Prophylactic Antibiotics on Length of Stay and Total Costs for Pediatric Acute Pancreatitis
Authors: Ikeda Kurakawa Kayo , Okada Akira , Jo Taisuke , Ono Sachiko , Bessho Kazuhiko , Michihata Nobuaki , Matsui Hiroki , Yamaguchi Satoko , Fushimi Kiyohide , Kadowaki Takashi , Yasunaga Hideo 
Published: October 2020

Objectives
Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pediatric patients. The aim of this study was to evaluate the effects of early prophylactic antibiotics on length of stay and total costs in pediatric patients.

Methods
Using the Japanese Diagnosis Procedure Combination database from 2010 to 2017, we used the stabilized inverse probability of treatment weighting method using propensity scores to balance the background characteristics in the antibiotics group and the control group, and compared length of stay and total costs between the groups.

Results
We found significant differences between the antibiotics group (n = 652) and the control group (n = 467) in length of stay (11 days vs 9 days; percent difference, 15.4%; 95% confidence interval, 5.0%–26.8%) and total costs (US $4085 vs US $3648; percent difference, 19.8%; 95% confidence interval, 8.0%–32.9%).

Conclusions
Prophylactic antibiotics were associated with longer length of stay and higher total costs. Our results do not support routine use of prophylactic antibiotics in pediatric AP populations.
Therapeutic Strategies Toward Lactate Dehydrogenase Within the Tumor Microenvironment of Pancreatic Cancer
Authors: Moir John A. G. , Long Anna , Haugk Beate , French Jeremy J. , Charnley Richard M. , Manas Derek M. , Wedge Steve R. , Mann Jelena , Robinson Stuart M. , White Steve A. 
Published: October 2020

Objectives
Pancreatic stellate cells (PSCs) play a key metabolic role within the tumor microenvironment (stroma) of pancreatic ductal adenocarcinoma (PDAC), being glycolytic and associated with protumorigenic acidification from excess lactate. This study investigates the clinical significance of glycolytic enzyme lactate dehydrogenase (LDH) and determines efficacy of the novel pan-LDH inhibitor Galloflavin.

Methods
An in vitro Transwell system was adopted for coculture of PSCs and 3 PDAC cell lines (MIA PaCa-2, PANC-1, and BxPC-3). Cells were treated with Galloflavin, and outcomes were analyzed regarding proliferation, apoptosis, lactate production, and glycolytic enzyme protein expression. Immunohistochemical staining for lactate dehydrogenase B (LDHB) was performed on 59 resected PDAC tumors annotated for clinical outcome.

Results
Galloflavin reduced PDAC proliferation in monoculture (P < 0.01); however, in co-culture with PSCs, an antiproliferative effect was only evident in PANC-1 (P = 0.001). An apoptotic effect was observed in MIA PaCa-2 and BxPC-3 in coculture (P < 0.05). A reduction in media lactate was observed in coculture (P < 0.01) with PSCs. Immunohistochemistry revealed stromal and tumoral LDHB expression had no impact on survival.

Conclusions
Galloflavin has the potential to neutralize the acidic PDAC microenvironment and thereby reduce tumor invasiveness and metastasis. Patients with lower LDHB expression are more likely to be beneficial responders.
Active palpation underlying shape perception is shaped by physiological thresholds and experience
Authors: Mizrachi Neomi , Nelinger Guy , Ahissar Ehud , Arieli Amos 
Published: October 2020

ABSTRACTHand movements are essential for tactile perception of objects. However, why different individuals converge on specific movement patterns is not yet clear. Focusing on planar shape perception, we tracked the hands of 11 participants while they practiced shape recognition. Our results show that planar shape perception is mediated by contour-following movements, either tangential to the contour or spatially-oscillating perpendicular to it, and by scanning movements, crossing between distant parts of the shapes’ contour. Both strategies exhibited non-uniform coverage of the shapes’ contours. We found that choice of strategy during the first experimental session was strongly correlated with two idiosyncratic parameters: participants with lower tactile resolution tended to move faster; and faster-adapting participants tended to employ oscillatory movements more often. In addition, practicing on isolated geometric features increased the tendency to use the contour-following strategy. These results provide insights into the processes of strategy selection in tactile perception.SIGNIFICANCE STATMENTHand movements are integral components of tactile perception. Yet, the specific motion strategies used to perceive specific objects and features, and their dependence on physiological features and on experience, are understudied. Focusing on planar shape perception and using high-speed hand tracking we show that human participants employ two basic palpation strategies: Contour-following and scanning. We further show that the strategy chosen by each participant and its kinematics depend strongly on the participant’s physiological thresholds – indicative of spatial resolution and temporal adaptation - and on their perceptual experience.
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
Authors: Wang Feng , Morita Kiyomi , DiNardo Courtney D , Furudate Ken , Tanaka Tomoyuki , Yan Yuanqing , Patel Keyur P. , MacBeth Kyle J. , Wu Bin , Liu Guowen , Frattini Mark , Matthews Jairo A. , Little Latasha D. , Gumbs Curtis , Song Xingzhi , Zhang Jianhua , Thompson Erika J. , Kadia Tapan M. , Garcia-Manero Guillermo , Jabbour Elias , Ravandi Farhad , Bhalla Kapil , Konopleva Marina , Kantarjian Hagop M. , Futreal P. Andrew , Takahashi Koichi 
Published: October 2020

AbstractAllosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resistance and acquired resistance to the drugs are major clinical issues. To understand the molecular underpinnings of clinical resistance to IDH inhibitors (IDHi), we performed multipronged genomic analyses (DNA sequencing, RNA sequencing and cytosine methylation profiling) in longitudinally collected specimens from 68 IDH1-orIDH2-mutant AML patients treated with the inhibitors. The analysis revealed that leukemia stemness is a major driver of primary resistance to IDHi, whereas selection of mutations inRUNX1/CEBPAorRAS-RTKpathway genes was the main driver of acquired resistance to IDHi, along withBCOR, homologousIDHgene, andTET2. These data suggest that targeting stemness and certain high-risk co-occurring mutations may overcome resistance to IDHi in AML.