bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair
Authors: Chae Suhun , Sun Yucheng , Choi Yeong-Jin , Ha Dong-Heon , Jeon Inho , Cho Dong-Woo 
Published: December 2020

Abstract
The tendon-bone interface (TBI) in rotator cuffs exhibits a structural and compositional gradient integrated through the fibrocartilaginous transition. Owing to restricted healing capacity, functional regeneration of the TBI is considered a great clinical challenge. Here, we establish a novel therapeutic platform based on 3D cell-printing and tissue-specific bioinks to achieve spatially-graded physiology for functional TBI regeneration. The 3D cell-printed TBI patch constructs are created via a spatial arrangement of cell-laden tendon and bone-specific bioinks in a graded manner, approximating a multi-tissue fibrocartilaginous interface. This TBI patch offers a cell favorable microenvironment, including high cell viability, proliferative capacity, and zonal-specific differentiation of encapsulated stem cells for TBI formation in vitro. Furthermore, in vivo application of spatially-graded TBI patches with stem cells demonstrates their regenerative potential, indicating that repair with 3D cell-printed TBI patch significantly accelerates and promotes TBI healing in a rat chronic tear model. Therefore, our findings propose a new therapeutic strategy for functional TBI regeneration using 3D cell-printing and tissue-specific decellularized extracellular matrix bioink-based approach.
Invasive Woody Plants and Their Effects on Arthropods in the United States: Challenges and Opportunities
Authors: Lalk Sara , Hartshorn Jess , Coyle David R 
Published: December 2020

AbstractInvasive plant introductions are increasing globally, and trends in human activity suggest these increases will continue. Although we know much about interactions between invasive herbaceous plants and arthropod communities, there is a dearth of knowledge examining interactions between invasive woody plants and arthropod communities. What information does exist shows that invasive woody plant relationships with mutualists (e.g., pollinators), herbivores, twig- and stem-borers, leaf-litter and soil-dwelling arthropods, and other arthropod groups are complex and hint at multiple factors influencing effects. These relationships warrant additional attention to allow better prioritization of species for research and regulatory review. Chinese tallow tree, e.g., is renowned for its attractiveness to honeybees, whereas reduced pollinator populations are found among other invasive woody plants such as privet. The unknown driving mechanisms and interactions that create these differences represent a substantial gap in knowledge and warrant additional research. Our objectives are to review current knowledge regarding invasive woody plants and their interactions with various arthropod groups in the United States, outline future research needs, and present a call to action regarding invasive woody plant research.
Transposition and Normalization of the Mini-Mental State Examination in French Sign Language
Authors: Fleurion Delphine , Verdun Stéphane , Ridoux Isabelle , Scemama Corine , Bouillevaux Isabelle , Ciosi Anna , Drion Benoît 
Published: December 2020

Abstract

Objective
Due to the lack of a validated translation, the mini-mental state examination (MMSE) cannot be used to screen for suspected dementia in deaf people who communicate in French Sign Language (FSL). Taking into consideration the cultural and linguistic features of this specific population, we transposed the validated French version of the MMSE into a version adapted to FSL users: mini-mental state-langue des signes (MMS-LS). The objective of our work was to obtain screening norms for the MMS-LS.

Methods
The MMS-LS was tested on 194 deaf users of FSL with clinical dementia rating as the gold standard. Healthy and demented participants were seen for two or three consecutive testing sessions at 1-year intervals.

Results
The MMS-LS exhibited excellent internal coherence validity (Cronbach’s α = .81), unidimensionality (p = .002), and excellent sensitivity (p &lt; .001). The MMS-LS score declined with overt and severe dementia.

Conclusion
The percentiles obtained are useful norms for clinical assessment but must be interpreted with precaution due to the small number of participants (related to recruitment constraints) in the present study. In order to facilitate clinical use, the MMS-LS has been made available online, together with an instructions manual and clinical advice useful for improved awareness of the specific nature of this population.
Remarkable sexually dimorphic features ofConiceromyia(Diptera: Phoridae): evolution in the light of phylogeny and comparative evidence about their function
Authors: Ament Danilo C , Hash John M , Almeida Eduardo A B 
Published: December 2020

AbstractConiceromyia is a genus of 100 species of phorid flies mostly distributed in the Neotropical region. The genus is distinguishable based on several male-exclusive features in different parts of the body, many of which are unique among the Phoridae. In addition, many species of Coniceromyia have nearly identical morphology of their male copulatory apparatus (i.e. hypopygium). The co-occurrence of these unusual characteristics suggests an evolutionary correlation between them. To investigate this possible correlation and to understand other aspects of the evolution of these puzzling male-exclusive characters, we performed the first phylogenetic analysis of Coniceromyia, based on morphological and molecular data. Ancestral state reconstructions and comparative analyses then allowed us to infer the evolution of these characters and search for general evolutionary patterns and correlated histories. We demonstrate that these male-exclusive features varied from highly homoplastic to uniquely derived on the phylogenetic history of Coniceromyia. For some characters, we found evidence of a biased evolution favouring gains over losses of the feature, but no male characteristics were significantly correlated with hypopygium morphology. The evolutionary patterns of the male-exclusive features and comparative evidence with other better known groups suggest possible functions for these features related to sexual selection.
The Impact of Surgical Strategy and Rifampin on Treatment Outcome in Cutibacterium Periprosthetic Joint Infections
Authors: Kusejko Katharina , Auñón Álvaro , Jost Bernhard , Natividad Benito , Strahm Carol , Thurnheer Christine , Pablo-Marcos Daniel , Slama Dorsaf , Scanferla Giulia , Uckay Ilker , Waldmann Isabelle , Esteban Jaime , Lora-Tamayo Jaime , Clauss Martin , Fernandez-Sampedro Marta , Wouthuyzen-Bakker Marjan , Ferrari Matteo Carlo , Gassmann Natalie , Sendi Parham , Jent Philipp , Morand Philippe C , Vijayvargiya Prakhar , Trebše Rihard , Patel Robin , Kouyos Roger D , Corvec Stéphane , Kramer Tobias Siegfried , Stadelmann Vincent A , Achermann Yvonne 
Published: December 2020

Abstract

Background
Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These infections are often treated with β-lactams or clindamycin as monotherapy, or in combination with rifampin. Clinical evidence supporting the value of adding rifampin for treatment of Cutibacterium PJI is lacking.

Methods
In this multicenter retrospective study, we evaluated patients with Cutibacterium PJI and a minimal follow-up of 12 months. The primary endpoint was clinical success, defined by the absence of infection relapse or new infection. We used Fisher’s exact tests and Cox proportional hazards models to analyze the effect of rifampin and other factors on clinical success after PJI.

Results
We included 187 patients (72.2% male, median age 67 years) with a median follow-up of 36 months. The surgical intervention was a 2-stage exchange in 95 (50.8%), 1-stage exchange in 51 (27.3%), debridement and implant retention (DAIR) in 34 (18.2%), and explantation without reimplantation in 7 (3.7%) patients. Rifampin was included in the antibiotic regimen in 81 (43.3%) cases. Infection relapse occurred in 28 (15.0%), and new infection in 13 (7.0%) cases. In the time-to-event analysis, DAIR (adjusted hazard ratio [HR] = 2.15, P = .03) and antibiotic treatment over 6 weeks (adjusted HR = 0.29, P = .0002) significantly influenced treatment failure. We observed a tentative evidence for a beneficial effect of adding rifampin to the antibiotic treatment—though not statistically significant for treatment failure (adjusted HR = 0.5, P = .07) and not for relapses (adjusted HR = 0.5, P = .10).

Conclusions
We conclude that a rifampin combination is not markedly superior in Cutibacterium PJI, but a dedicated prospective multicenter study is needed.
CausalBuilder: bringing the MI2CAST causal interaction annotation standard to the curator
Authors: Touré Vasundra , Zobolas John , Kuiper Martin , Vercruysse Steven 
Published: December 2020

Abstract
Molecular causal interactions are defined as regulatory connections between biological components. They are commonly retrieved from biological experiments and can be used for connecting biological molecules together to enable the building of regulatory computational models that represent biological systems. However, including a molecular causal interaction in a model requires assessing its relevance to that model, based on the detailed knowledge about the biomolecules, interaction type and biological context. In order to standardize the representation of this knowledge in ‘causal statements’, we recently developed the Minimum Information about a Molecular Interaction Causal Statement (MI2CAST) guidelines. Here, we introduce causalBuilder: an intuitive web-based curation interface for the annotation of molecular causal interactions that comply with the MI2CAST standard. The causalBuilder prototype essentially embeds the MI2CAST curation guidelines in its interface and makes its rules easy to follow by a curator. In addition, causalBuilder serves as an original application of the Visual Syntax Method general-purpose curation technology and provides both curators and tool developers with an interface that can be fully configured to allow focusing on selected MI2CAST concepts to annotate. After the information is entered, the causalBuilder prototype produces genuine causal statements that can be exported in different formats.
Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial
Authors: Vermeire Séverine , Su Chinyu , Lawendy Nervin , Kobayashi Taku , Sandborn William J , Rubin David T , Modesto Irene , Gardiner Sean , Kulisek Nicole , Zhang Haiying , Wang Wenjin , Panés Julian 
Published: December 2020

Abstract

Background and Aims
Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present primary completion analysis from RIVETING, an ongoing, double-blind, randomised, parallel-group trial evaluating efficacy and safety of tofacitinib dose reduction to 5 mg twice daily [BID] versus remaining on 10 mg BID in patients in stable remission on tofacitinib 10 mg BID maintenance therapy.

Methods
Patients had received tofacitinib 10 mg BID for ≥ 2 consecutive years and been in stable remission for ≥ 6 months before enrolment. The primary endpoint was modified Mayo score remission at Month 6. Safety was assessed up to February 20, 2020 [data cut-off].

Results
In all, 140 patients were randomised [1:1] to tofacitinib 5 or 10 mg BID; 77.1% and 90.0% of patients in the 5 and 10 mg BID groups, respectively, were in modified Mayo score remission at Month 6 (adjusted difference 12.9%; 95% confidence interval [CI] 0.5–25.0). Smaller differences between treatment groups were seen in patients with baseline endoscopic subscore of 0 versus 1 [9.8%; –3.0–22.6, and 21.1%; –6.1–48.2, respectively], and in patients without versus with prior tumour necrosis factor inhibitor [TNFi] failure [9.5%; –6.6–25.6, and 17.4%; –1.6–36.3, respectively]. Adverse events [AE] and serious AE rates were similar across treatment groups; no deaths were reported.

Conclusions
Most patients in stable remission on 10 mg BID maintenance therapy maintained remission following dose de-escalation. For patients who dose de-escalated, those in deep endoscopic remission and those without prior TNFi failure were more likely to maintain remission. Efficacy data were limited to the first 6 months; a longer duration of follow-up during RIVETING will further characterise the impact of dose reduction on maintenance of remission. Safety findings were consistent with the established safety profile of tofacitinib.
Sex-specific associations between alcohol consumption, cardiac morphology, and function as assessed by magnetic resonance imaging: insights form the UK Biobank Population Study
Authors: Simon Judit , Fung Kenneth , Kolossváry Márton , Sanghvi Mihir M. , Aung Nay , Paiva Jose Miguel , Lukaschuk Elena , Carapella Valentina , Merkely Béla , Bittencourt Marcio S. , Karády Júlia , Lee Aaron M. , Piechnik Stefan K. , Neubauer Stefan , Maurovich-Horvat Pál , Petersen Steffen E. 
Published: December 2020

Abstract

Aims
Data regarding the effects of regular alcohol consumption on cardiac anatomy and function are scarce. Therefore, we sought to determine the relationship between regular alcohol intake and cardiac structure and function as evaluated with cardiac magnetic resonance imaging.

Methods and results
Participants of the UK Biobank who underwent cardiac magnetic resonance were enrolled in our analysis. Data regarding regular alcohol consumption were obtained from questionnaires filled in by the study participants. Exclusion criteria were poor image quality, missing, or incongruent data regarding alcohol drinking habits, prior drinking, presence of heart failure or angina, and prior myocardial infarction or stroke. Overall, 4335 participants (61.5 ± 7.5 years, 47.6% male) were analysed. We used multivariate linear regression models adjusted for age, ethnicity, body mass index, smoking, hypertension, diabetes mellitus, physical activity, cholesterol level, and Townsend deprivation index to examine the relationship between regular alcohol intake and cardiac structure and function. In men, alcohol intake was independently associated with marginally increased left ventricular end-diastolic volume [β = 0.14; 95% confidence interval (CI) = 0.05–0.24; P = 0.004], left ventricular stroke volume (β = 0.08; 95% CI = 0.03–0.14; P = 0.005), and right ventricular stroke volume (β = 0.08; 95% CI = 0.02–0.13; P = 0.006). In women, alcohol consumption was associated with increased left atrium volume (β = 0.14; 95% CI = 0.04–0.23; P = 0.006).

Conclusion
Alcohol consumption is independently associated with a marginal increase in left and right ventricular volumes in men, but not in women, whereas alcohol intake showed an association with increased left atrium volume in women. Our results suggest that there is only minimal relationship between regular alcohol consumption and cardiac morphology and function in an asymptomatic middle-aged population.
Cardiac computed tomography in cardio-oncology: an update on recent clinical applications
Authors: Rosmini Stefania , Aggarwal Ankita , Chen Daniel H , Conibear John , Davies Ceri L , Dey Amit Kumar , Edwards Paula , Guha Avirup , Ghosh Arjun K 
Published: December 2020

Abstract
Chemotherapy and radiotherapy have drastically improved cancer survival, but they can result in significant short- and long-term cardiovascular complications, most commonly heart failure from chemotherapy, whilst radiotherapy increases the risk of premature coronary artery disease (CAD), valve, and pericardial diseases. Cardiac computed tomography (CT) with calcium scoring has a role in screening asymptomatic patients for premature CAD, cardiac CT angiography (CTCA) allows the identification of significant CAD, also in the acute settings where concerns exist towards invasive angiography. CTCA integrates the diagnostic work-up and guides surgical/percutaneous management of valvular heart diseases and allows the assessment of pericardial conditions, including detection of effusion and pericardial calcification. It is a widely available and fast imaging modality that allows a one-step evaluation of CAD, myocardial, valvular, and pericardial disease. This review aims to provide an update on its current use and accompanying evidence-base for cardiac CT in the management of cardio-oncology patients.
Long-term results of concomitant atrioventricular valve intervention and the Fontan operation
Authors: Yang Yang , Feng Zicong , Ma Kai , Zhang Sen , Zhang Benqing , Qi Lei , Wang Guanxi , Li Shoujun 
Published: December 2020

Abstract

OBJECTIVES
The optimal timing for atrioventricular valve (AVV) repair in patients with a Fontan circulation remains controversial. Few studies have reported the long-term outcomes of AVV repair concomitant with a Fontan operation.

METHODS
From January 2006 to December 2018, a total of 89 patients who developed moderate or severe AVV regurgitation before a Fontan operation were divided into 2 groups: group 1, including 37 patients who did not undergo concomitant AVV repair; and group 2, including 52 patients who received AVV repair concomitant with a Fontan operation.

RESULTS
The mean age at the time of the Fontan operation was 6.74 years for group 1 and 8.96 years for group 2, respectively. Early death occurred in 3 patients [2 patients (5.4%) in group 2, patient 1 (1.9%) in group 1]. Freedom from long-term death, cardiac function reduction and protein-losing enteropathy were similar among the 2 groups. Common AVV function was apparently poorer than mitral valve function after repair [hazard ratio (HR) 3.83, 95% confidence interval (CI) 1.31–11.17; P = 0.014]. The occurrence of AVV valve failure in group 1 was lower than that in group 2 (HR 0.44, 95% CI 0.22–0.91; P = 0.026). AVV function became worse during the follow-up period than that at discharge in both groups (P = 0.03 in group 1 and P = 0.001 in group 2).

CONCLUSIONS
The long-term results of AVV repair concomitant with a Fontan operation are favourable.
How Does Age Shape Social Interactions? Interviewer-Age Effects, Normative Age Distance, and Gender Attitudes
Authors: Hu Yang 
Published: December 2020

Abstract
Age is one of the most widely used indicators in social research. However, the ways in which age influences the dynamics and outcomes of social interactions have received insufficient attention. The contextual configurations of this influence are particularly under-researched. Analyzing data from the European Social Survey, I exploit the case of a survey interview as a microcosm of social interactions to examine the ways in which age influences respondent–interviewer interactions and shapes people’s articulation of gender attitudes. I disentangle whether interviewer’s age influences respondents’ gender-attitude reports directly or via its interaction with respondent’s age. I develop the concept of normative age distance in gender attitudes—the young–old inter-cohort difference in gender attitudes in a given country–year—to examine how it moderates interviewer-age effects. The results suggest that respondents draw on the normative age distance to associate stereotypical gender attitudes with the interviewer’s age and to make sense of their age distance from the interviewer when reporting their gender attitudes. Respondents are more sensitive to the interviewer’s age when the respondent–interviewer age difference is wider and the normative age distance in gender attitudes is greater. Older respondents are more sensitive to normative age distance in gender attitudes when responding to the interviewer’s age. The results provide new insights into how age configures social interactions, underline the importance of understanding survey interviews as contextually embedded symbolic interactions, and reflect critically on methodological challenges to survey design and data analysis.
Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank
Authors: Wang Mengying , Zhou Tao , Song Yongze , Li Xiang , Ma Hao , Hu Yonghua , Heianza Yoriko , Qi Lu 
Published: December 2020

Abstract

Aims
Little is known about the relation between the long-term joint exposure to various ambient air pollutants and the incidence of heart failure (HF). We aimed to assess the joint association of various air pollutants with HF risk and examine the modification effect of the genetic susceptibility.

Methods and results
This study included 432 530 participants free of HF, atrial fibrillation, or coronary heart disease in the UK Biobank study. All participants were enrolled from 2006 to 2010 and followed up to 2018. The information on particulate matter (PM) with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), and between 2.5 and 10 µm (PM2.5–10) as well as nitrogen oxides (NO2 and NOx) was collected. We newly proposed an air pollution score to assess the joint exposure to the five air pollutants through summing each pollutant concentration weighted by the regression coefficients with HF from single-pollutant models. We also calculated the weighted genetic risk score of HF. During a median of 10.1 years (4 346 642 person-years) of follow-up, we documented 4201 incident HF. The hazard ratios (HRs) [95% confidence interval (CI)] of HF for a 10 µg/m3 increase in PM2.5, PM10, PM2.5–10, NO2, and NOx were 1.85 (1.34–2.55), 1.61 (1.30–2.00), 1.13 (0.80–1.59), 1.10 (1.04–1.15), and 1.04 (1.02–1.06), respectively. We found that the air pollution score was associated with an increased risk of incident HF in a dose–response fashion. The HRs (95% CI) of HF were 1.16 (1.05–1.28), 1.19 (1.08–1.32), 1.21 (1.09–1.35), and 1.31 (1.17–1.48) in higher quintile groups compared with the lowest quintile of the air pollution score (P trend &lt;0.001). In addition, we observed that the elevated risk of HF associated with a higher air pollution score was strengthened by the genetic susceptibility to HF.

Conclusion
Our results indicate that the long-term joint exposure to various air pollutants including PM2.5, PM10, PM2.5–10, NO2, and NOx is associated with an elevated risk of incident HF in an additive manner. Our findings highlight the importance to comprehensively assess various air pollutants in relation to the HF risk.