bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRAFV600E-induced senescence drives Langerhans Cell Histiocytosis pathophysiology
Authors: Merad Miriam 
Published: November 2020

Abstract
Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNP) harboring activating somatic mutations in MAPK pathway genes, most notably BRAFV600E. We recently discovered that the BRAFV600E mutation can also affect multipotent hematopoietic progenitor cells (HPC) in multisystem LCH disease. How BRAFV600E mutation in HPC leads to LCH is not known. Here we show that enforced expression of the BRAFV600E mutation in early mouse and human multipotent HPC induced a senescence program that led to HPC growth arrest, apoptosis resistance and senescence-associated secretory phenotype (SASP). SASP, in turn, promoted HPC skewing towards the MNP lineage leading to the accumulation of senescent MNP in tissue and the formation of LCH lesions. Accordingly, elimination of senescent cells using INK-ATTAC transgenic mice as well as pharmacologic blockade of SASP improved LCH disease in mice. These results identify senescent cells as a novel target for the treatment of LCH.
Supramolecular Cocrystals Built Through Redox-Triggered ion Intercalation in π-Conjugated Polymers
Authors: Yanashita Yu , Tsurumi Junto , Kurosawa Tadanori , Ueji Kan , Tsuneda Yukina , Kohno Shinya , Kempe Hideto , Kumagai Shohei , Okamoto Toshihiro , Takeya Jun , Watanabe Shun 
Published: November 2020

Abstract
Self-organization in π-conjugated polymers gives rise to a highly ordered lamellar structure, in which inter-chain stacking spontaneously forms two-dimensional conjugated sheets. This multi-layer stacked nature of semicrystalline polymers results not only in effective charge transport, but also allows the inclusion of various functional molecules and ions. In particular, redox-triggered ion-intercalation in a polymer's lamellae is an ideal system for molecular doping, for which extremely high charge carrier density, corresponding to one carrier per monomer unit, has been achieved. We conducted a detailed structural analysis and electron density simulation to pinpoint exactly where the guest dopants are located periodically in the restricted void space in a polymer's lamellae. Our findings are indicative of an intercalation compound of layered polymers and a guest intercalant. In addition, we show that a homogeneous cocrystal structure can be realized throughout the host polymer medium, which is proved unambiguously by the observation of coherent carrier transport across microscopic-scale films. Also, the intercalation cocrystal nature gives the best achievable doping level in semicrystalline conjugated polymers and excellent environmental stability. These findings should open up new possibilities for tuning the collective dynamics of functional molecules and ions through intercalation phenomena.
Determinant of Food Security Within the COVID-19 Epidemic Circumstances- A Special Case of Chinese Agriculture Food Production and Distribution Industries
Authors: Sarkar Apurbo , Peau Anamika Kor , Al Asif Abdullah , Qian Lu , Das Jiban Chandro 
Published: November 2020

Abstract
PurposeSince the outbreak of the COVID-19 epidemic rises, it poses a catastrophic effect for the society and its development globally. These pandemic situations put global inhabitants under tremendous pressure to maintain a sufficient supply of nutrition and desirable food security. Agricultural food production and distribution industries may play a vital role in determining the current conditions of any countries food security and sustainable development goals. Design/methodology/approachSince an increasing number of people had been suffering from hunger and malnutrition before even the infection strikes, it could create more dangerous circumstances by creating a global food crisis if the immediate measure is not taken. This paper examines the determinants of food security within three distinct aspects (effective utilization of food, food availability, and food access) within the COVID-19 epidemic situation. For developing and validating the model, the empirical data was collected from the agricultural food supply industry in China (Shaanxi Province). Whereas, the core analytical assumption has made by employing the exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modelling (SEM).FindingsAfter analyzing the data collected from 67 agricultural food productions and distribution personnel along with the hypothesis testing, it has found that determinants of the effective utilization if food aspects are positively related to the determinants of food availability and food access aspects, and the determinants of food availability are positively related to the food access determinants. OriginalityThis research will be helpful to the government and industry in developing policies and strategies for the successful implementation of all the associated determinants of food security in terms of the epidemic situation.
Prognostic Indicators and Short Term Outcomes for Operated Patients with Peritonitis: Prospective Cohort Hospital Based Study in Northern Tanzania
Authors: Msuya Nassib Daud , Alloyce Julius Pius , Msuya David , Chilonga Kondo , Herman Ayesiga , Chugulu Samuel 
Published: November 2020

Abstract
Background: Peritonitis is one of the most common surgical emergencies all over the world and is associated with significant complications and mortality. The spectrum of aetiology of peritonitis differs between high income countries and low income countries. Majority of the patients present late with purulent peritonitis and septiceamia. Surgical treatment of peritonitis is highly demanding and very complex, however, if the outcome in these patients can be correctly predicted, then better management can be instituted in order to achieve optimal patients’ care and hence improve treatment outcome.Methods: Prospective cohort hospital based study was conducted among patients admitted due to peritonitis at Kilimanjaro Christian medical center (KCMC) from October 2018 to March 2019.Documentary review and interview methods were employed to obtain data using electronic structured questionnaire. Data was summarized using median, Inter-quartile range (IQR), frequency and percentage. Both bivariate and multivariate logistic regression analyses were used to identify prognostic indicators for post-operative complications and mortality. A 95% CI and P <0.05 used for significance test.Results: The study enrolled 70 patients with predominance of male, giving a male to female ratio of 4.1:1. A total number of 33(47.1%) developed complications and 16(22.9%) died. Only 1(1.43%) patient presented to the hospital within 24 hours since the onset of illness. Delay in care, longer duration of operation, and low potassium were the prognostic indicators noted to have influence on short term complications. The major influence for mortality were comorbidity (AOR=3.02; 95%CI: 2.25-42.90) and postoperative complications (dyselectrolaemia) with (AOR=9.27; 95%CI: 1.21-70.83).Conclusion: Mortality and complications resulted from peritonitis is unacceptably high. Delay in care, longer duration of operation and preoperative low serum potassium levels were the prognostic indicators for the post-operative complications. Comorbidity and postoperative complications such as dyselectrolaemia had influence for the mortality. Correct prediction of these adverse outcomes will help to institute better management for the patients with peritonitis.
A new method to rapidly and accurately assess the mechanical properties of geologically relevant materials
Authors: Deng Pu , Herrera Sean V. , Prorok Barton C. 
Published: November 2020

AbstractA new indentation-based method was developed that will impact and facilitate the elastic property measurements of rocks and minerals, especially those possessing unusual deformation behavior, including brittle materials and those with complex architectures. The novel feature employed is a metallic film that uniformly transfers the load from the indenter tip to the sample. The film also absorbs the damage caused by the penetrating indenter, shielding the material from highly localized deformation that can impact its response to loading. Many geologically relevant materials have resisted traditional indentation testing because they are either brittle in nature or possess highly anisotropic architectures, such as layered or lamellar structures. In both cases, the highly localized deformation from direct indentation significantly affects the indenter unloading stiffness, from which the elastic properties are determined. The indirect indentation method developed here has demonstrated accurate determination of the elastic properties of many common geological materials as well as materials that have resisted elastic characterization such as galena and talc.
Sisi Gelap Kepemimpinan Pentakostal-Karismatik
Authors: Pranoto Minggus M. 
Published: November 2020

Abstract
This article highlights a critical question: why is Pentecostal-Charismatic leadership vulnerable to various scandals? This model of leadership often exposes the dark side of leadership characterized by the issues of money, sex, and power. This study suggests that Pentecostal-Charismatic leaders are often trapped in the model of personalized charismatic leadership that is based on misinterpretation of the doctrine of being Spirit-filled. The method used in this article is that of practical theology relating the framework of socialized charismatic leadership to the theological concept of the church (ekklesia) as the body of Christ and the fellowship of the Holy Spirit.

Abstrak
Tulisan ini menyoroti pertanyaan kritis: mengapa kepemimpinan Pentakostal-Karismatik rentan terkena berbagai skandal? Model kepemimpinan ini acap kali memunculkan sisi gelap kepemimpinan yang ditandai oleh masalah-masalah keuangan, seksual, dan kekuasaan. Kajian ini mengungkapkan bahwa para pemimpin Pentakostal-Karismatik seringkali terjebak dalam model personalized charismatic leadership yang didasari oleh penafsiran yang keliru atas doktrin being Spirit-filled. Metode tulisan ini termasuk dalam ranah teologi praktis yang mengaitkan kerangka berpikir socialized charismatic leadership dengan konsep teologis tentang gereja (ekklesia) sebagai tubuh Kristus dan persekutuan Roh Kudus.
Kekristenan dan Spiritualitas Online: Cybertheology sebagai Sumbangsih Berteologi di Indonesia
Authors: Sopacoly Mick Mordekhai , Lattu Izak Y.M. 
Published: November 2020

Abstract
The mobilization of information, technology, and social change marked by the presence of cyberspace not only affects the way people think in building relationships with others and themselves but also the process of developing faith and spirituality. Using the methods of qualitative research, literature study, and Focus Group Discussion (FGD), this research finds that in the context of the COVID-19 pandemic, Christian religious patterns are changing drastically, driving all churches to move to virtual reality. The Christian notion of spirituality is also being transformed so that the experience with God is believed to occur not only in the physical space of the church but also in virtual reality. “Clickactivism” forms a new faith community determined by click and spiritual experiences which strength lies in the imagination of communities and individuals. This study concludes that cybertheology is an important contribution in helping Indonesian Christians to have a strong spiritualityabout God who cannot be confined within time and space.

Abstrak
Arus mobilisasi informasi, teknologi, dan perubahan sosial yang ditandai dengan adanya ruang cyber (cyberspace) ternyata tidak hanya mempengaruhi cara berpikir manusia dalam membangun relasi dengan sesama dan diri sendiri tetapi juga proses pengembangan iman dan spiritualitasnya. Metode yang digunakan ialah penelitian kualitatif, studi literatur, dan Focus Group Discussion (FGD). Hasil penelitian menemukan bahwa dalam konteks pandemi COVID-19, pola beragama Kristen berubah secara drastis sehingga memaksa semua gereja untuk pindah ke realitas virtual. Pemahaman kekristenan tentang spiritualitas juga bertransformasi sehingga pengalaman dengan Tuhan diyakini tidak terbatas dalam ruang fisik gereja tetapi juga dalam realitas virtual. “Aktivitas klik” membentuk sebuah komunitas iman yang baru, yang ditentukan oleh klik dan pengalaman spiritual yang kekuatannya terletak pada imajinasi komunitas dan individu. Karena itu, studi ini menyimpulkan bahwa teologi cyber menjadi kontribusi penting untuk membantu kekristenan di Indonesia untuk berspiritualitas mengenai Tuhan yang tidak dapat dikurung dalam ruang dan waktu.
Stormwater harvesting infrastructure systems design for urban park irrigation: Brimbank Park, Melbourne case study
Authors: Day Jake Kyle , Sharma Ashok K 
Published: November 2020

Abstract
Stormwater harvesting for residential and non-residential reuse is an important and crucial aspect to reduce freshwater demand to address climate change, population growth and urbanisation challenges. It is important that freshwater be conserved as much as possible through capturing rainwater and stormwater and using these resources for fit for purpose end uses such as irrigation of public open parks and residential non-potable end uses. The paper describes a methodology for the planning and design of a stormwater harvesting system for park irrigation. The application of suitable models for storage tank capacity and pipe sizing considering peak flows are described. The application of the approach is demonstrated with a local case study for the benefit of wider water professionals engaged in water-sensitive urban design.
Ecological-environmental quality estimation using remote sensing and combined artificial intelligence techniques
Authors: Nourani Vahid , Foroumandi Ehsan , Sharghi Elnaz , Dąbrowska Dominika 
Published: November 2020

Abstract
Ecological-environmental quality was evaluated for Tabriz and Rasht cities (in Iran) with different climate conditions using artificial intelligence (AI) and remote sensing (RS) techniques. Sampling sites were surveyed and ecological experts assigned eco-environment background values (EBVs) of sites. Then, eco-environmental attributes were extracted as RS derived, and meteorological attributes were observed. Three AI-based models, artificial neural network (ANN), support vector regression (SVR), and adaptive neuro-fuzzy inference system (ANFIS) were then applied to learn the relationship between a target set of known EBVs and eco-environmental attributes as inputs. According to the results of the single models, none of the models could evaluate EBV appropriately for all regions and classes. Thereafter, three combining techniques were applied to the outputs of single models to enhance spatial evaluation of EBV. It was observed that the modeling for Tabriz led to more accurate results. It seems that the better network performance for Tabriz may be due to a more heterogeneous dataset in this kind of climate. Furthermore, results indicated that SVR led to better performance than both ANN and ANFIS models, but the models' combining techniques were shown to be superior. Combining techniques enhanced performance of single AI modeling up to 26% in the verification step.
Numerical solutions of hyperbolic systems of conservation laws combining unsteady friction and viscoelastic pipes
Authors: Seck Aboudou 
Published: November 2020

Abstract
The main contribution of the paper is to incorporate pipe-wall viscoelastic and unsteady friction in the derivation of the water-hammer solutions of non-conservative hyperbolic systems with conserved quantities as variables. The system is solved using the Godunov finite volume scheme to obtain numerical solutions. This results in the appearance of a new term in the mass conservation equation of the classical governing system. This new numerical algorithm implements the Godunov approach to one-dimensional hyperbolic systems of conservation laws on a finite volume stencil. The viscoelastic pipe-wall response in the mass conservation part of the source term has been modeled using generalized Kelvin–Voigt theory. For the momentum part of the source term a fast, robust and accurate numerical scheme linked to the Lambert W-function for calculating the friction factor has been used. A case study has been used to illustrate the influence of the various formulations; a comparison between the classical solution, the numerical solution including quasi-steady friction, the numerical solution incorporating the viscoelastic effects, and measurements are presented. The inclusion of viscoelastic effects results in better agreement between the measured and solved values.
Actual Problems of Statistical Study of Economic Assets in Modern Conditions
Authors: Salin V. N. , Vakhrameeva M. V. , Sitnikova O. Y. 
Published: November 2020

Purpose of research. It is necessary to clearly define the composition and structure of economic assets to conduct a systematic statistical analysis of the state and development of the national economy, including at the level of sectors, subsectors and institutional units.The purpose of the work is to systematize data on the availability and movement of economic assets in the context of information sources, methods of their assessment and analysis of the practice of macroeconomic calculations.Materials and methods. In this paper, the authors considered the classification of economic assets, applied structural and dynamic data analysis, as well as methods of theoretical research in the form of generalization, comparison, and special analytical procedures.Results. Statistical study of economic transactions with assets involves a detailed review of the groupings and classifications of assets at the level of institutional units, sectors of the economy and the economy as a whole, which will provide reliable information about their availability and movement. In addition, it is necessary to understand the essence of statistical indicators that reflect the state and change in the value of assets, the methodology for their calculation, comprehensive analysis and practical use. The paper defines the main directions for studying economic assets based on current international standards, taking into account national statistical practice.Conclusion. As part of a systematic statistical analysis of the state and development of the national economy in various areas, it is necessary to clearly define the composition and structure of economic assets, their place and significance in the production of goods and services.The issue of assessing the value of economic assets, which should reflect their market value, is of significant importance. Improving methods for assessing economic assets is an urgent problem not only for macroeconomic calculations, but also for adequately reflecting economic operations at the level of institutional units and sectors of the economy.Economic assets are recognized as such if they bring economic benefits to their owner. Evaluating the effectiveness of asset use in economic activities or asset ownership is no less challenging for analysts. Such analytical procedures require a comprehensive analysis of data on the availability and movement of assets, their composition and structure, including from an international perspective.The authors of the article have repeatedly addressed the issues of macroeconomic calculations in their publications, which allowed them to consider in more detail topical issues related to the accumulation of non-financial and financial assets.
Simultaneous Optimization of Activity and Stability of Xylose Reductase from D. nepalensis NCYC 3413 Using Statistical Experimental Design
Authors: Malla Shwethashree , Gummadi Sathyanarayana N. 
Published: November 2020

Background:
Physical parameters like pH and temperature play a major role in the design
of an industrial enzymatic process. Enzyme stability and activity are greatly influenced by these
parameters; hence optimization and control of these parameters becomes a key point in determining
the economic feasibility of the process.

Objective:
This study was taken up with the objective to optimize physical parameters for maximum stability and activity of
xylose reductase from D. nepalensis NCYC 3413 through separate and simultaneous optimization studies and comparison
thereof.

Method:
Effects of pH and temperature on the activity and stability of xylose reductase from Debaryomyces nepalensis
NCYC 3413 were investigated by enzyme assays and independent variables were optimised using surface response methodology. Enzyme activity and stability were optimised separately and concurrently to decipher the appropriate conditions.

Results:
Optimized conditions of pH and temperature for xylose reductase activity were determined to be 7.1 and 27 ℃ respectively, with predicted responses of specific activity (72.3 U/mg) and half-life time (566 min). The experimental values
(specific activity 50.2 U/mg, half-life time 818 min) were on par with predicted values indicating the significance of the
model.

Conclusion:
Simultaneous optimization of xylose reductase activity and stability using statistical methods is effective as
compared to optimisation of the parameters separately.
Purification of Classical Swine Fever Virus E2 Subunit Vaccines Based on High Affinity Peptide Ligand
Authors: Wang Fangyu , Yu Qiuying , Hu Man , Xing Guangxu , Zhao Dong , Zhang Gaiping 
Published: November 2020

Background:
The purification of expressed proteins is the most critical part of subunit--
vaccine production. Protein-purification methods such as affinity chromatography and ion
exchange still have the shortcomings of being time consuming and complicated. With the rapid development
of computational molecular-simulation technology, structure-based peptide-ligand design
has become feasible.

Objection:
We aimed to apply molecular docking for a peptide ligand designed for classical swine fever virus (CSFV) E2
purification.

Methods:
Computational-derived peptides were synthesized, and the in vitro binding interaction
with E2 was investigated. The effects of purification on E2 were also evaluated.

Results:
The best peptide recognizing E2 was P6, which had a sequence of KKFYWRYWEH.
Based on kinetic surface plasmon resonance (SPR) analysis, the apparent affinity constant of P6
was found to be 148 nM. Importantly, P6 showed suitable binding affinity and specificity for E2 purification
from transgenic rice seeds. Evaluation of immune antibodies in mice showed that the antibody-
blocking rate on day 42 after inoculation reached 86.18% and 90.68%.

Conclusion:
The computational-designed peptide in this study has high sensitivity and selectivity
and is thus useful for the purification of CSFV E2. The novel method of design provided a broad
platform and powerful tool for protein-peptide screening, as well as new insights into CSFV
vaccine design.