bluuebunny/crossref_metadata_2025_split huggingface dataset:
Woman Searching for Family Nafkah in Islamic Economic Views
Authors: Nurhadi Nurhadi 
Published: August 2020

Abstract: This article focuses on the discussion of Islamic and economic views on women making a living for families (husbands and children). This phenomenon is already popular in Indonesian society, with many female workers (TKW) making a living or working abroad for the sake of family survival (husband and children), this is also reinforced by soap opera shows on private national television titled “The world is upside down” as a manifestation of the socio-economic facts of the Indonesian family today which is visualized as soap operas. This is a big question mark for socio-economic observers and practitioners of sakinah or Muslim families. In general, the main task of making a family living in Islam is assigned to the man (husband). Although it is justified that women (wives) earn a living (working) to help the family economy if the husband’s income is insufficient for family needs, provided that the woman in work does not bring shame, slander and harm to herself and the continuity of her household, and can maintain her honor by always covering aurat and keep away from things that produce salaries are not halal (haram). So a woman who is a family breadwinner in the view of Islamic economics is permitted, but that as an alternative to maintaining survival and domestic life with her husband and children, also does not violate her nature as a wife and mother for her children. This analysis arises because economic activity is a social activity, so the social is very closely related to the economy, also the Islamic economy and ocioeconomic family in Islam.
Effectiveness and Tolerability of Repetitive Transcranial Magnetic Stimulation for Preventive Treatment of Episodic Migraine: A Single Centre, Randomised, Double-Blind, Sham-Controlled Phase 2 Trial (Magnet-EM).&nbsp;&nbsp;
Authors: Safiai Nabil Izzaatie Mohamad , Amir Nur Ain , Basri Hamidon bin , Mat Liyana Najwa Inche , Hoo Fan Kee , Khan Abdul Hanif Khan Yusof , Loh Wei Chao , Chia Peck Kee , Ramachandran Vasudevan , Din Hazwan Mat , Samsudin Intan Nureslyna , Fernandez Aaron , Mohamed Mohd Hazmi , Ching Siew Mooi , Hashim Hasnur Zaman , Sulaiman Wan Aliaa Wan 
Published: August 2020

Abstract
Background: This is a phase II randomised, double-blind, sham-controlled trial to evaluate the effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine among migraine subjects. Methods: Subjects age 18 to 60 years will undergo a baseline evaluation to establish the diagnosis of migraine based on International Classification of Headache Disorder 3rd Edition (ICHD-3). Those who fulfil the ICHD-3 criteria for episodic migraine and compliant to the headache diary during a month run-in period will be enrolled. A total of 76 subjects will be randomised to receive either transcranial magnetic stimulation or sham stimulation for 5 sessions within 2 weeks duration. Follow-up sessions will be conducted monthly for three consecutive months. Prior to treatment, subjects will be required to fill up questionnaires and undergo few procedures such as electroencephalography, transcranial doppler ultrasound and biochemical analysis for serum serotonin, serum calcitonin-gene related peptide and serum beta-endorphin. These procedures will be repeated at month 3 after receiving last treatment. The primary outcome measure of this study is the difference in mean monthly migraine days at baseline and at month 1, 2 and 3 after treatment sessions. Discussion: Following evidence from previous studies showing restoration of dorsolateral prefrontal cortex (DLPFC) activation to almost normal level, the rTMS intervention will target left DLPFC in this study. Meanwhile, the least number of treatment sessions reported which proved to be effective in reducing migraine days was three session of rTMS given in alternate days. Hence, an intermediate duration of treatment sessions is selected for this study. It is set to five treatment sessions given within 2 weeks duration. Trial registration: NCT03556722. Transcranial Magnetic Stimulation in Episodic Migraine (Magnet-EM) was registered on 27th April 2018. https://clinicaltrials.gov/ct2/show/NCT03556722.
Identification of Nucleus Sterility Candidate Genes using a Resequencing Technique in Sweet Pepper Sterile Line AB91
Authors: Meng yaning , Yan Libin , Zhang Hongxiao , Fan Yanqin 
Published: August 2020

Abstract
Background:Breeding hybrids with nuclear malesterile lines is an important method for the cross breeding of sweet peppers. To date, few reports have been published on the nuclear malesterility gene of sweet pepper.Yet, there are approximately 20 pepper nuclear malesterility lines in the world. Results: Using the self-developed testing material, sweet pepper nuclear malesterile dual-purpose line AB91, the genome-wide resequencing technique was applied to firstly find that the mutation site causing the abortion of sweet pepper nuclear malesterility AB91 is on chromosome #5. The mutation gene Capana05g000747 was filtered out and validated by the flight mass spectrometry genotyping and quantitative real-time PCR method and determined to be the gene causing the abortion of sweet pepper nuclear male sterility AB91.The gene Capana05g000747 mutation site is a non-synonymous mutation site located at the 6th exon,the base C mutated into A, and the amino acid changed from alanine to serine. The three-dimensional protein structure of fertile and sterile plant Capana05g000747 was predicted. The results showed that the three-dimensional structure of the two proteins was differed significantly. Sequence alignment analysis showed that the gene Capana05g000747 has a similar function to gene At2g02148. The gene At2g02148 contains a pentatricopeptide repeatprotein which has important physiological functions in the gene expression process of organelles and is closely related to the performance of malesterility genes. Conclusions: This study revealed that Capana05g000747 was selected as an important candidate gene for sweet pepper nuclear male sterile testingmaterial AB91.This gene provides a theoretical and technical foundation for further cloning as well as transformation and utilization of the gene.
Comparing effects of two higher intensity feedback interventions with simple feedback on improving staff communication in nursing homes – The INFORM cluster-randomized controlled trial
Authors: Hoben Matthias , Ginsburg Liane R , Easterbrook Adam , Norton Peter G , Anderson Ruth A , Andersen Elizabeth A , Boström Anne-Marie , Cranley Lisa A , Lanham Holly J , Weeks Lori E , Cummings Greta G , Holroyd-Leduc Jayna M , Squires Janet E , Wagg Adrian S , Estabrooks Carole A 
Published: August 2020

Abstract
Background: Effective communication among interdisciplinary healthcare teams is essential for quality healthcare, especially in nursing homes (NHs). Care aides provide most direct care in NHs, yet are rarely included in formal communications about resident care (e.g., change of shift reports, family conferences). Audit and feedback is a potentially effective improvement intervention. This study compares the effect of simple and two higher intensity levels of feedback based on Goal Setting Theory on improving formal staff communication in NHs.Methods: This pragmatic three-arm parallel cluster-randomized controlled trial included NHs participating in TREC (Translating Research in Elder Care) across the Canadian provinces of Alberta and British Columbia. Facilities with at least one care unit with 10 or more care aide responses on the TREC baseline survey were eligible. At baseline, 4,641 care aides and 1,693 nurses cared for 8,766 residents in 67 eligible NHs. NHs were randomly allocated to a simple (control) group (22 homes, 60 care units) or one of two higher intensity feedback intervention groups (based on Goal Setting Theory): basic assisted feedback (22 homes, 69 care units) and enhanced assisted feedback 2 (23 homes, 72 care units). Our primary outcome was the amount of formal communication about resident care that involved care aides, measured by the Alberta Context Tool and presented as adjusted mean differences [95% confidence interval] between study arms at 12-month follow-up.Results: Baseline and follow-up data were available for 20 homes (57 care units, 751 care aides, 2,428 residents) in the control group, 19 homes (61 care units, 836 care aides, 2,387 residents) in the basic group, and 14 homes (45 care units, 615 care aides, 1,584 residents) in the enhanced group. Compared to simple feedback, care aide involvement in formal communications at follow-up was 0.17 points higher in both the basic ([0.03; 0.32], p=0.021) and enhanced groups ([0.01; 0.33], p=0.035). We found no difference in this outcome between the two higher intensity groups.Conclusions: Theoretically informed feedback was superior to simple feedback in improving care aides’ involvement in formal communications about resident care. This underlines that prior estimates for efficacy of audit and feedback may be constrained by the type of feedback intervention tested.Trial registration: ClinicalTrials.gov (NCT02695836), https://clinicaltrials.gov/ct2/show/NCT02695836, registered on March 1, 2016
Disability and its prevalence and cause in northwestern Ethiopia: evidence from Dabat district of Amhara National Regional State: A community based cross-sectional study
Authors: Abebe Solomon Mekonnen , Nega Ansha , Gizaw Zemichel , Bayisa Mulugeta , Fasika Solomon , Belay Molalign , Fekadu Abel , Abera Mikyas 
Published: August 2020

Abstract
Background Disability is not just a factor of an individual’s physical condition; it develops through human interactions and reflects the social fabric of communities. Despite the fact that it directly affects 15% of Ethiopians, understanding and policy-relevant studies on disability and the conditions of persons with disabilities are lacking. The Dabat Demographic and Health Surveillance System part of the response to fill this gap. With significant drawbacks in the Surveillance System, this study aimed at assessing the prevalence, types and major causes of disability in Dabat district.Method A community-based cross-sectional study design was employed and covered 17,000 households residing in 13 Kebeles of Dabat district. The district is where DHSS collects health data semi-annually; but this study was designed and executed separately in 2018 utilizing robust tools (World Health Organization’s Disability Assessment Schedule (WHODAS 2.0) used to collect comprehensive data on disability in the district. The data was organized and presented using frequencies and percentages in table and figures. Relevant variables were used to construct a logit model that predicts the likelihood of disability whereby P-value < 0.05 was considered as statistically significant.Results This study found that the overall prevalence of disability in Dabat district was 2.14% [95% CI: 2.03, 2.24]. About 8.3% of households reported at least one member with disability. Visual impairment was the most commonly reported impairment d51%) while 8.19% had multiple impairments. Eighty-three percent of immediate the causes of disability were modifiable – specifically, illness (36.93%), injury (17.81%), and congenital (10.86%). The aged [AOR=1.0; 95% CI: 1.03, 1.04], those unable to read or write illiterate [AOR=1.57; 1.15,2.14], the unmarried/single [AOR=1.39; 95% CI: 185,2.47] and the separated [AOR=2.78; 95% CI: 4.14,6.19] were more likely to risk disability in the population.Conclusion This study reported an increased likelihood of impairment among those with advanced ages. The proportion of households with PwDs was also high. While most disabilities were visual, there were significant numbers with mobility impairments and hard of hearing. Most school-age PwDs did not complete secondary education, while employment was significantly limited. The findings indicated that most causes of disability were reversible.
Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after a standardized oral intake of both saturated and unsaturated fats
Authors: Fawad Ayesha , Fernandez Celine , Bergmann Andreas , Struck Joachim , Nilsson Peter M , Bennet Louise , Orho-Melander Marju , Melander Olle 
Published: August 2020

Abstract
Background: In rodents, neurotensin contributes to high fat diet induced obesity by facilitation of intestinal fat absorption. The effect of oral lipid load on plasma proneurotensin and relationship with plasma triglycerides in humans is unknown.Aim: To investigate the acute effects of an oral lipid load on proneurotensin and plasma triglycerides and their interrelationships in healthy individuals.Setting/ Methods: Twenty-two healthy subjects were given 150 mL of full milk cream (54g fat) and 59 mL of pure olive oil (54 g fat) in the fasted state at two different occasions separated by at least 1 week in random order. Venous blood was drawn at fasted before 0 hours (h) and at 1 h, 2 h and 4 h after ingestion. Post-ingested values of proneurotensin and plasma triglycerides were compared with fasting levels and post ingestion Area Under the Curve (AUC) of proneurotensin was correlated with that of plasma triglycerides.Results: An immediate rise of plasma proneurotensin and plasma triglycerides were observed after ingestion of cream with maximum increase at 2 h for proneurotensin [mean (95% confidence interval)] of 22 (12-31) pmol/L (P<0.001) and at 3 h for triglycerides of 0.60 (0.43-0.78) mmol/L (P<0.001). Similarly, plasma proneurotensin and plasma triglycerides increased after ingestion of olive oil with maximum increase of proneurotensin at 3 h of 62 (46-78) pmol/L (P<0.001) and plasma triglycerides at 3 h of 0.32 (0.18-0.45) mmol/L (P<0.001). The post lipid load AUC for proneurotensin correlated significantly with the AUC for plasma triglycerides both after cream (r=0.49, P=0.021) and olive oil (r=0.55, P=0.008), respectively.Conclusion: Proneurotensin increases after an oral lipid load of both cream and olive oil and the rise of post-ingestion plasma triglycerides is significantly related to the rise of post-ingestion proneurotensin.
Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesis
Authors: Zhang Meng , Han Yu , Zhai Yanhui , Ma Xiangfei , An Xinglan , Zhang Sheng , Li Ziyi 
Published: August 2020

Abstract
Background: Tissue-specific fat deposition is regulated by a series of complex regulatory mechanisms. Reports indicate that epigenetic regulators, such as circular RNAs (circRNAs), are crucial in diseases progression, animal development, metabolism, and adipogenesis. In this study, to assess the functional roles of circRNAs in adipogenesis and tissue-specific fat deposition, we comprehensively analyzed the Ribo-Zero RNA-Seq and miRNAs data during chicken intramuscular and abdominal adipogenic differentiation. Results: circRNAs and miRNAs profiles during chicken adipogenic differentiation were found in adipocytes derived from various adipose tissues. It was also discovered that high levels of downregulated miRNAs potentially promote adipogenesis by activating their target genes which are associated with fatty acid metabolism and adipogenic differentiation. Through analysis of the correlation between the expression levels of circRNAs and adipogenic genes, as well as the dynamic expression patterns of circRNAs during adipogenic differentiation, several candidate circRNAs were identified. Moreover, competing endogenous RNA (ceRNAs) networks were constructed during chicken intramuscular and abdominal adipogenesis by combining miRNAs with mRNAs data. Several candidate circRNAs potentially influence adipogenesis by regulating miRNAs via PPAR and fatty acid metabolism-related pathways were identified, such as circLCLAT1, circFNDC3AL, circCLEC19A and circARMH1. Conclusion: In conclusion, our findings reveal that circRNAs and the circRNA-miRNAs-mRNAs-ceRNAs network may play important roles in chicken adipocytes differentiation and tissue-specific fat deposition.
The Effect of Social Norm-based Intervention with Observable Behaviour on Physical Activity among Adolescents: A Randomized Controlled Trial
Authors: Lee Jia Jia , Nadkarni Nivedita Vikas , Teo Irene , Ozdemir Semra 
Published: August 2020

Abstract
Background: The rising prevalence of childhood obesity in developing and developed countries poses a major public health challenge to policy makers and an effective strategy to promote physical activity among adolescents is warranted. This study aimed to evaluate the effectiveness of providing descriptive norms messages with personal identification in promoting physical activity among adolescents by measuring step counts via a randomized controlled trial (NCT03081013). Methods: A total of 311 participants aged 13-16 were randomized into two study arms (Onymous and Anonymous Arms). Each arm consisted of 13 groups of 12 participants. During the trial, participants received weekly short message service (SMS) about their past week’s physical activity performance Participants in the Anonymous Arm received information about step counts of group members ranked from highest to lowest. Participants in the Onymous Arm received the same information with the group members’ full names. Participants’ quality of life, depression, and physical activity social support, self-efficacy and enjoyment before and after the intervention were also evaluated. This study adheres to the CONSORT guidelines.Results: The number of steps was not higher when descriptive norm message was onymous compared to when it was anonymous. Scores in quality of life, depression, social support, self-efficacy, and enjoyment of physical activity were not significantly different between both arms (p>0.05).Conclusions: Our findings indicated that the effect of providing descriptive norms messages containing personal identification on physical activity promotion was not evident in the main analysis. Future studies may consider using a more relevant reference group to use social norms as a tool to increase physical activity among adolescents.Word count: 202 wordsTrial registration: ClinicalTrials.gov - NCT03081013. Registered 15 Mar 2017-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03081013
The experience of loneliness among young people with depression: a qualitative meta-synthesis of the literature
Authors: Achterbergh Louis , Pitman Alexandra , Birken Mary , Pearce Eiluned , Sno Herman , Johnson Sonia 
Published: August 2020

Abstract
Background: Young people have a higher prevalence of loneliness than other age groups, and they are also at risk of depression. Quantitative studies describe a bidirectional association between loneliness and depression, but there is limited understanding of how these influence each other. Little is known about the experience of loneliness among young people with depression. Qualitative approaches may help understand the relationship between loneliness and depression among young people, and how to intervene to improve outcomes. We aimed to conduct a meta-synthesis to understand the complex inter-relationship between loneliness and depression among young depressed people by synthesising evidence from a systematic review of qualitative studies.Methods: We conducted a meta-synthesis of qualitative studies capturing experiences of loneliness among young people with depression. We systematically searched six electronic databases for selected search terms, critically appraised eligible studies, and analysed the data from included studies using the approach of thematic synthesis. We used feedback from an inter-disciplinary research workshop to improve reflexivity. Results: Our inclusion criteria identified fourteen studies. Our analysis identified four themes: (1) social withdrawal due to poor mental health, (2) non-disclosure of depression contributing to social distance, (3) the desire to connect, and (4) paradoxes of loneliness and depression. These themes illustrated a range of pathways between depression and loneliness, and a sense of how these might be mutually reinforcing. Our findings suggest that where depressed individuals engage in certain behaviours (withdrawing; not confiding) for a range of reasons, this can lead to feelings of loneliness, an awareness of which worsens their mood, thus perpetuating their depression. Conclusions: Young people with depression experience loneliness as an insurmountable distance between themselves and others. Our findings identified non-disclosure of depression, and the debilitating nature of the depressive symptomatology, as factors perpetuating a vicious cycle of loneliness and depression. They suggest that approaches to tackling the problem might include helping young people communicate about their depression to trusted friends and educating their social networks in how to support them. The wider research literature suggests that cognitive interventions may have a role in shifting maladaptive cognitions about their social world.
The changes of gut microbiota in drug-naïve first-episode MDD patients under treatment by SSRIs
Authors: Shen Yang , Yang Xiao , Li Gaofei , Xing Xiaoxi , Li Zhiyong , Huang Yichen , Gao Jiayu , Ying Liang 
Published: August 2020

Abstract
Background: Recently, several studies reported that transplanting stool from depressed patients could induce depression-like behaviors in mice. In addition, antidepressants presented not only antidepressant effects, but also antibacterial effects in those animals. Therefore, this study firstly investigated on the changes of gut microbiota in depressed patients under effective antidepressant treatment.Methods: We recruited 30 patients with drug-naive first-episode MDD (Patients group) and 30 healthy controls (Control group), and collected their stool samples to complete 16S rRNA sequencing. Next, Patients group received 15-20 mg/d of escitalopram. After the symptoms improved, the feces of Patients group were collected and marked as Follow-up group to complete sequencing for the second time. We then investigated into the differences of gut microbiota between patients (Patients and Follow-up groups) and controls (Control group), the characteristics of gut microbiota under treatment, and the potential differences in metabolic functions. Results: A significant difference in gut microbiota abundance was found after escitalopram treatment. The Firmicutes/Bacteroides ratio significantly decreased in the Follow-up group. After treatment, the species diversity of gut microbiota tended to be back to normal state in Follow-up group. The mainly difference of metabolic function were found as follows: Transport and catabolism, Nervous system, Glycan biosynthesis and metabolism.Conclusions: Under escitalopram treatment, the gut microbiota diversity of MDD patients tended to back to normal state. However, several structures and metabolic pathways in microbes remained differences between patients and controls, which might be related to the relapse of MDD.