bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential anti-adipogenic activity ofCalligonum comosumcuminaldehyde on mouse 3T3-preadipocytes
Authors: Mohammad Mohammad G , El-Serafi Ahmed , Madkour Mohamed I. , Alhabshi Abeer , Wadea Ansar , Jabal Rola Abu , Divyasree P , Soliman Sameh S.M. 
Published: July 2020

AbstractObesity is a medical condition associated with serious medical and psycho-social consequences and an augmented body fat mass. Several compounds were suggested to counteract obesity and fat accumulation with variable degrees of success. Searching for a safe and effective anti-adipogenic substance, we found that cuminaldehyde-rich essential oil extracted fromCalligonum comosumpotentially mediate activities. The results showed thatC. comosumessential oil and its major component cuminaldehyde, selectively caused significant reduction in the viability of 3T3-L1 cells when compared to fibroblasts. Furthermore, cuminaldehyde caused significant reduction in the lipid content, glucose uptake and levels of both triglycerides and cholesterol in adipocytes. Moreover, the formation of 3D-adipocyte pellets in the presence of cuminaldeyde was affected. Adipocytes matured in the presence of cuminaldehyde have significant reduction in the expression of adipocyte-specific transcripts, CAAT-enhancer binding protein alpha (CEBPa) and Peroxisome proliferator-activated receptor gamma (PPARg). Taken together, these results demonstrate a potential inhibitory role of cuminaldehyde extracted fromC. comosumoil on lipid accumulation. Consequently, cuminaldeyde can be considered as a new potential anti-adipogenic agent for prevention and treatment of obesity.
How far are we in the rapid prediction of drug resistance caused by kinase mutations?
Authors: Erguven Mehmet , Karakulak Tülay , Diril M. Kasim , Karaca Ezgi 
Published: July 2020

ABSTRACTProtein kinases regulate various cell signaling events in a diverse range of species through phosphorylation. The phosphorylation occurs upon transferring the terminal phosphate of an ATP molecule to a designated target residue. Due to the central role of protein kinases in proliferative pathways, point mutations occurring within or in the vicinity of ATP binding pocket can render the enzyme overactive, leading to cancer. Combatting such mutation-induced effects with the available drugs has been a challenge, since these mutations usually happen to be drug resistant. Therefore, the functional study of naturally and/or artificially occurring kinase mutations have been at the center of attention in diverse biology-related disciplines. Unfortunately, rapid experimental exploration of the impact of such mutations remains to be a challenge due to technical and economical limitations. Therefore, the availability of kinase-ligand binding affinity prediction tools is of great importance. Within this context, we have tested six state-of-the-art web-based affinity predictors (DSX-ONLINE, KDEEP, HADDOCK2.2, PDBePISA, Pose&Rank, and PRODIGY-LIG) in assessing the impact of kinase mutations with their ligand interactions. This assessment is performed on our structure-based protein kinase mutation benchmark, BINDKIN. BINDKIN contains 23 wild type-mutant pairs of kinase-small molecule complexes, together with their corresponding binding affinity data (in the form of IC50, Kd, and Ki). The web-server performances over BINDKIN show that the raw server predictions fail to produce good correlations with the experimental data. However, when we start looking in to the direction of change (whether a mutation improves/worsens the binding), we observe that over Kidata, DSX-ONLINE achieves a Pearson’s R correlation coefficient of 0.97. When we used homology models instead of crystal structures, this correlation drops to 0.45. These results highlight that there is still room to improve the available web-based predictors to estimate the impact of protein kinase point mutations. We present our BINDKIN benchmark and all the related results online for the sake of aiding such improvement efforts. Our files can be reached athttps://github.com/CSB-KaracaLab/BINDKIN
Autism identification across ethnic groups: a narrative review
Authors: Tromans Samuel , Chester Verity , Gemegah Eli , Roberts Kristian , Morgan Zoe , Yao Guiqing Lily , Brugha Traolach 
Published: July 2020

PurposeThe purpose of the paper is to review autism identification across different ethnic groups. Diagnosis of autism may be missed or delayed in certain ethnic groups, leading to such groups being underserved relative to their needs. This can result in members of such groups being effectively denied essential avenues of support that can substantially improve the quality of life of autistic persons as well as those whom care for them.Design/methodology/approachA literature search for articles reporting autism identification across ethnic groups was undertaken. Data are compared, with a special focus on possible explanations for any inter-group variation.FindingsAutism identification appears to be generally lower in minority ethnic groups relative to the majority population. Individuals presenting with autism from minority groups appear to have more severe forms of the condition.Originality/valueThere are a multitude of potential explanations for inter-ethnicity variation in autism identification, including health care-related factors, broader environmental influences, cultural factors and possible biological differences. Implications for clinical practice and public health include a need to look at means of ensuring equitable access to relevant autism diagnostic and support services across ethnic groups. Further work is required to better understand the belief systems that operate within specific ethnic groups, how this may potentially impact upon autism identification and measures to address the concerns of such groups.
Expressivity in children with autism and Williams syndrome
Authors: Lai Philip To 
Published: July 2020

PurposeThe purpose of this study is to investigate the social and affective aspects of communication in school-age children with HFA and school-age children with WS using a micro-analytic approach. Social communication is important for success at home, school, work and in the community. Lacking the ability to effectively process and convey information can lead to deficits in social communication. Individuals with high functioning autism (HFA) and individuals with Williams syndrome (WS) often have significant impairments in social communication that impact their relationships with others. Currently, little is known about how school-age children use and integrate verbal and non-verbal behaviors in the context of a social interaction.Design/methodology/approachA micro-analytic coding scheme was devised to reveal which channels children use to convey information. Language, eye gaze behaviors and facial expressions of the child were coded during this dyadic social interaction. These behaviors were coded throughout the entire interview, as well as when the child was the speaker and when the child was the listener.FindingsLanguage results continue to pose problems for the HFA and WS groups compared to their typically developing (TD) peers. For non-verbal communicative behaviors, a qualitative difference in the use of eye gaze was found between the HFA and WS groups. For facial expression, the WS and TD groups produced more facial expressions than the HFA group.Research limitations/implicationsNo differences were observed in the HFA group when playing different roles in a conversation, suggesting they are not as sensitive to the social rules of a conversation as their peers. Insights from this study add knowledge toward understanding social-communicative development in school-age children.Originality/valueIn this study, two non-verbal behaviors will be assessed in multiple contexts: the entire biographical interview, when the child is the speaker and when the child is the listener. These social and expressive measures give an indication of how expressive school-age children are and provide information on their attention, affective state and communication skills when conversing with an adult. Insights from this study will add knowledge toward understanding social-communicative development in school-age children.
Examining team performance: the role of psychological contracts and engagement among co-workers
Authors: Schreuder Frits , Schalk René , Batistič Sasa 
Published: July 2020

PurposeThe aim of this study was to investigate the role of shared psychological contract beliefs between colleagues in a work team, in team in-role performance and extra-role behaviours.Design/methodology/approachEmployees and team managers of 113 work teams answered questions about their working environment and relationships with experiences and perceptions. The data were used in CFA and structural modelling.FindingsThe results indicated that evaluations of co-worker psychological contracts in work teams are significantly associated with team in-role performance and extra-role behaviours through work engagement.Practical implicationsEmployees with perceived contract fulfilment not only contribute more to their team but also change their expectations of what a team should offer. Managers should be informed that these new and enhanced expectations have repercussions for existing HRM practices.Originality/valueLaulié and Tekleab (2016) have suggested that perceptions of psychological contract fulfilment shared by team members may act as a motivational driver for team performance, team attitudes and behaviours. This study is one of the first applications of this proposition in a mediation model and empirically tested for non-hierarchical co-worker relationships.
Should the cost of capital, used in connection with goodwill impairment testing, vary across countries?
Authors: Salameh Elie 
Published: July 2020

Learning outcomes
Through the discussion of this case, students will have better understanding of the conceptual stakes related to accounting treatment for goodwill and factors determining goodwill impairment testing. The case also discusses the determination of the cost of capital and the impact of taking into account certain factors related to country risk for determining the discount rate in an international framework.

Case overview/synopsis
Greenfields Company continues to expand through acquisitions in emerging markets. The company aims to overcome the complexity of measuring goodwill subsequent to the initial recognition. The case was written to illustrate challenges of estimating the appropriate discount rate to be used in the goodwill impairment testing as investments in emerging countries give rise to many discount rate measurement problems such as the availability of statistical data and the risk assessment to be considered.

Complexity academic level
The case can be used at undergraduate or postgraduate level and it requires fundamental knowledge in accounting and corporate finance.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 1: Accounting and Finance.
Entrepreneurial habits in the Kenya red cross society
Authors: Ndemo Bitange , Mkalama Benedict , Aiko Dennis Moiro 
Published: July 2020

Learning outcomes
The case study takes students through basic principles and applications of entrepreneurship theory as demonstrated by the story of Kenya Red Cross Society (KRCS). The case further demonstrates the significance of communicating a rallying vision in a change management situation. The case further allows the students to evaluate the concept and implication of entrepreneurial leadership thereby enhancing creativity and innovativeness in a firm.

Case overview/synopsis
An area that has had little interaction in the study of entrepreneurship is within the development and humanitarian agencies. This is a case study on Entrepreneurial Habits in the KRCS. The leadership of KRCS combined different entrepreneurial actions that were able to deliver commercial goals in a not-for-profit organization. The final overarching consideration was the sustainability of the changes implemented over a period of time.

Complexity academic level
Graduate level.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.
The case of motivprints: balancing entrepreneurial instinct with managerial approach
Authors: Bhatt Kedar , Singh Abhinava S. 
Published: July 2020

Learning outcomes
After studying this case, the students/participants would be able to: discuss important personality traits of an entrepreneur; understand specific challenges faced by a venture as it moves toward higher growth stage; discuss the importance of strategic planning and managerial style as the ventures move from establishment stage to growth stage.

Case overview/synopsis
The case is about MotivPrints, a two years old venture, offering custom designing and commercial printing to businesses in Gujarat, India. MotivPrints was established by Himanshu Dhadnekar in 2016 and had 85 SME clients and 35 vendors by 2019. Himanshu, a young entrepreneur had been involved in entrepreneurial activities since his school days and was also involved in a couple of business ventures during his MBA. However, he had been flip-flopping as an employee and entrepreneur, as then. At MotivPrints, he handled key responsibilities of developing client networks, generating business, marketing and managing relationship with vendors. With limited support of a team of freelancer associates, no permanent staff for assistance and lack of funds made it imperative for Himanshu to plan for scaling up his venture for survival and growth. Could he envision MotivPrints as a larger entity? If yes, what changes, mandated by growth, were needed to be made in both – the entrepreneur and the organization?

Complexity academic level
The case can be discussed in the class of entrepreneurship at the master’s level. It can also be used in the entrepreneurship specialization course in the second year of post-graduation. The case can be also be used for young entrepreneurs in an executive development program focusing on new ventures.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS: 3 Entrepreneurship.
Facilitation of team communication skill among engineers: an empirical study
Authors: Mehta Nikhil K. , Jha Sumi 
Published: July 2020

PurposeThe purpose of the study is to understand the team communication skill among students with engineering background.Design/methodology/approachLabour market offers more employment to those who have better social skills than those who fair less on these skills. It is pertinent to integrate these skills among engineers. In the study, a Qual-quant-Qual platform was created to develop social skill andragogy for engineers from India. Involving 132 engineers, the authors gathered qualitative and quantitative data to understand their perspective on communication and the emergent factors of team communication skill.FindingsThe qualitative study supports the view that despite theoretical awareness, the actions may differ. The factor analysis of the data revealed five important factors of interpersonal communication. The study offers six utilities in support of andragogy.Originality/valueThe study offers a platform to engineers to internalize and reflect differences in order for the real learning to take place, and it also offers space to faculty members to simulate and offer relevant interventions.
Thermal convection in a chamber filled with a nanosuspension driven by a chemical reaction using Tiwari and Das’ model
Authors: Sheremet Mikhail A. , Grosan Teodor , Pop Ioan 
Published: July 2020

Purpose
The purpose of this paper is to study numerically the steady thermal convection in a chamber filled with a nanoliquid affected by a chemical reaction using the single-phase nanofluid approximation.

Design/methodology/approach
Water was considered as a host fluid while nanoparticles are aluminum oxide. Homogeneous reactions are analyzed. The nonlinear partial differential equations describing the considered problem are simulated using the finite difference technique.

Findings
The results of streamlines, isotherms, isoconcentrations, nanofluid flow rate, mean Nusselt and Sherwood numbers are discussed. The data demonstrate that the mean Sherwood number increases with the homogeneous reaction rate. Further, nanofluid flow rate can be increased with nanoparticles concentration for high Rayleigh numbers owing to the homogeneous chemical reaction inside the cavity.

Originality/value
Searching the existent references illustrates that the homogeneous-heterogeneous reactions influence on the nanoliquid motion and energy transport within enclosures has not been investigated before. The results of this paper are completely original and the numerical results of the present paper were never published by any researcher.
Adaptive task scheduling in IoT using reinforcement learning
Authors: Pandit Mohammad Khalid , Mir Roohie Naaz , Chishti Mohammad Ahsan 
Published: July 2020

PurposeThe intelligence in the Internet of Things (IoT) can be embedded by analyzing the huge volumes of data generated by it in an ultralow latency environment. The computational latency incurred by the cloud-only solution can be significantly brought down by the fog computing layer, which offers a computing infrastructure to minimize the latency in service delivery and execution. For this purpose, a task scheduling policy based on reinforcement learning (RL) is developed that can achieve the optimal resource utilization as well as minimum time to execute tasks and significantly reduce the communication costs during distributed execution.Design/methodology/approachTo realize this, the authors proposed a two-level neural network (NN)-based task scheduling system, where the first-level NN (feed-forward neural network/convolutional neural network [FFNN/CNN]) determines whether the data stream could be analyzed (executed) in the resource-constrained environment (edge/fog) or be directly forwarded to the cloud. The second-level NN ( RL module) schedules all the tasks sent by level 1 NN to fog layer, among the available fog devices. This real-time task assignment policy is used to minimize the total computational latency (makespan) as well as communication costs.FindingsExperimental results indicated that the RL technique works better than the computationally infeasible greedy approach for task scheduling and the combination of RL and task clustering algorithm reduces the communication costs significantly.Originality/valueThe proposed algorithm fundamentally solves the problem of task scheduling in real-time fog-based IoT with best resource utilization, minimum makespan and minimum communication cost between the tasks.
Diversity and health strategies for newly resettled refugees
Authors: Vikdahl Linda , Ståhle Göran , Gunnarsson David , Saboonchi Fredrik 
Published: July 2020

PurposeIn general, newly resettled refugees have poorer physical and mental health than native-born Swedes. This indicates that the society must make special efforts to enable refugees to attain health that is on a par with the rest of the population. The challenges rest primarily with employees in the public sector. But what resources do professionals need to meet the refugees’ health needs? This paper is about the need to develop strategies for professionals working with diversity and health, with a focus on the establishment of newly resettled refugees in Sweden. Thus, the purpose of this paper is to identify the needs and obstacles in working with diversity and health for the newly resettled.Design/methodology/approachThe paper is based on focus group interviews with 40 professionals working in three large municipalities and one County Administrative Board, all of whom work with challenges related to migration and health on a daily basis.FindingsThe needs expressed by the interviewees are primarily about developing and improving communications. Three important areas of communication were expressed: how information can be transferred from sender to receiver, institutionalization and interactions at different levels.Originality/valueThis paper identifies important needs and obstacles when working with diversity and health in Sweden, with a focus on the establishment of newly resettled refugees. It is an important contribution because refugees in general have poorer physical and mental health than native-born Swedes and strategies to improve their health, therefore, need to be further developed.
Hybrid RPL-based sensing and routing protocol for smart city
Authors: AlSawafi Yahya , Touzene Abderezak , Day Khaled , Alzeidi Nasser 
Published: July 2020

PurposeWireless sensor network (WSN) and mobile crowd sensing (MCS) technologies face some challenges, especially when deployed in a large environment such as a smart city environment. WSN faces network latency, packets delivery and limited lifetime due to the nature of the used constrained internet of things small devices and low power network. On the other hand, most of the current applications that adapt MCS technology use 3G or long term evalution network to collect data and send them directly to the server. This leads to higher battery and bandwidth consumption and higher data cost.Design/methodology/approachThis paper proposes a hybrid routing protocol based on the routing protocol (RPL) protocol that combines the two wireless sensing technologies (WSN and MCS) and allows the integration between them. The aim is to use MCS nodes in an opportunistic way to support static WSN nodes to enhance the performance.FindingsThe evaluation of the proposed protocol was conducted in a static WSN to study the impact of the integration on the WSN performance. The results reveal a good enhancement on packet delivery ratio (17% more), end-to-end delay (50% less) and power consumption (25% less) compared with native RPL (without MCS integration).Originality/valueThe authors believe that the hybrid-RPL protocol can be useful for sensing and data collection purposes, especially in urban areas and smart city contexts.
Mining GitHub for research and education: challenges and opportunities
Authors: AlMarzouq Mohammad , AlZaidan Abdullatif , AlDallal Jehad 
Published: July 2020

Purpose
This study aims to highlight the challenges and opportunities of using GitHub as a data source in both research and programming education.

Design/methodology/approach
This study provides general overview of the challenges and opportunities faced while conducting empirical research using GitHub as a data source. The challenges and opportunities are framed using the input–process–output model of open-source software.

Findings
GitHub data accessed from the application programming interface (API) can have several limitations, which can be overcome by Web scraping and using external data repositories such as GHArchive and GHTorrent. There are also several idiosyncrasies about GitHub that researchers need to be aware of to be able to use the data effectively, which can represent an opportunity for research. The challenges and opportunities are summarized for the licenses, community, development process and product of free/libra and open-source software communities hosted on GitHub.

Originality/value
This study provides a summary of GitHub-related challenges and opportunities that researchers can leverage to improve their empirical research. Furthermore, this summary can be a valuable resource for instructors that plan to use GitHub as a data source in their data-focused programming courses.