bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Implementasi E-audit untuk Pemeriksaan Keuangan Negara Studi pada BPK RI Perwakilan Daerah Istimewa Yogyakarta
Authors: Mubiroh Siti 
Published: May 2020

Badan Pemeriksa Keuangan (BPK) RI mempunyai peran penting dalam meningkatkan akuntabilitas keuangan negara. Dalam menjalankan tugasnya, BPK menghadapi permasalahan yaitu sumberdaya manusia yang terbatas dan waktu pemeriksaan yang terbilang singkat. Oleh karena itu BPK mengembangkan sistem informasi e-audit dalam pelaksanaan pemeriksaan pengelolaan dan tangungjawab keuangan negara. Penelitian ini menggunakan Model Kesuksesan Sistem Informasi DeLone dan McLean (2003) dengan menggunakan enam komponen yaitu System Quality, Information Quality, Service Quality, Information System Use, User Satisfaction, dan Net Benefits. Perbedaan penelitian ini dengan penelitian sebelumnya adalah penelitian ini menggunakan pendekatan kualitatif dengan metoda studi kasus dengan tujuan untuk mengetahui implementasi e-audit secara mendalam. Teknik pengambilan sampel menggunakan snowball sampling. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Informan dalam penelitian ini adalah auditor BPK RI Perwakilan DIY. Hasil penelitian ini menunjukkan bahwa fitur pencarian utama dan fitur data antar efektif digunakan dalam proses pemeriksaan keuangan pemerintah daerah, sedangkan fitur LKPD belum efektif digunakan dalam proses pemeriksaan keuangan pemerintah daerah.Kata Kunci: E-audit, DeLone and McLean Models, Audit Sistem Informasi
Nonoperative Treatment of Psoas Tendon Avulsion in a Professional Athlete
Authors: Ejnisman Leandro , Andrade-Silva Fernando Brandao , Pontin Pedro Augusto , Ottoni Jomar Jorge , Magliocca Gustavo Damásio , Safran Marc R 
Published: May 2020

Case:
A 36-year-old male professional soccer player sustained an acute left hip injury during a tournament game while defending the goal. Magnetic resonance imaging demonstrated a complete avulsion of the iliopsoas tendon from the left trochanter. The patient was treated nonoperatively, and after 10 weeks, he was able to return to full activity. After 1 year of follow-up, the patient was completely asymptomatic, and was still playing professional soccer without flexion strength deficit.

Conclusion:
In this professional soccer athlete, nonoperative treatment of complete psoas avulsion resulted in a good functional outcome and successful return to play.
Biohackers and Self-Made Problems: Infection of an Implanted RFID/NFC Chip
Authors: Schiffmann Alain , Clauss Martin , Honigmann Philipp 
Published: May 2020

Case:
We describe the case of a 26-year-old man with an infected Radio-Frequency-Identification/Near Field Communication (RFID/NFC) chip in the middle finger. The RFID/NFC chip was removed, the soft tissue debrided, and a pan-sensitive staphylococcus aureus was detected by sonication of the RFID/NFC chip. The patient was postoperatively treated with amoxicillin and clavulanic acid (24 hours iv, total 11 days) and an intrinsic plus splint which led to complete recovery.

Conclusion:
Modern body modifications can lead to infections which shouldn't be underestimated. Interdisciplinary treatment is a key to success.
Double Level Osteotomy Assisted by 3D Printing Technology in a Patient with Blount Disease
Authors: Gómez-Palomo Juan M. , Meschian-Coretti Stephan , Esteban-Castillo José L. , García-Vera Juan J. , Montañez-Heredia Elvira 
Published: May 2020

Case:
We describe the case of a 26-year-old patient diagnosed with Blount disease. She underwent a medial oblique supracondylar biplanar closing-wedge osteotomy of the distal femur followed by a medial oblique biplanar opening-wedge osteotomy of the proximal tibia. 3D printed cutting guides were used for the procedures. At 18 months after surgery, the patient is pain-free and walks without aids.

Conclusions:
Using 3D printed guides allowed for accurate correction of the deformity and reduced the risk of damaging critical structures. These guides could be an appropriate alternative for the surgical treatment of patients with Blount disease.
Nonoperative Treatment of a Pathologic Proximal Tibia Fracture in the Setting of Previous Total Knee Arthroplasty
Authors: Carender Christopher N. , Wynn Malynda S. , Otero Jesse E. , Miller Benjamin J. , Brown Timothy S. 
Published: May 2020

Case:
We present the case of a super obese 51-year-old woman with a pathologic fracture of the proximal tibia in the setting of a previous total knee arthroplasty. Imaging demonstrated an osteolytic lesion distal to the keel and pathologic fracture of the proximal tibia. Nonoperative treatment with a 12-week course of nonweight-bearing resulted in fracture healing and ossification of osteolysis.

Conclusion:
Pathologic fractures of the tibia secondary to osteolysis are frequently treated surgically. Patients may benefit from nonoperative management, even in the setting of super morbid obesity and significant osteolysis about the tibial component.
Humeral Head Osteochondral Allograft Reconstruction with Arthroscopic Anterior Shoulder Stabilization at a Long-Term Follow-Up
Authors: Sochacki Kyle R. , Dillingham Michael F. , Abrams Geoffrey D. , Sherman Seth L. , Donahue Joseph 
Published: May 2020

Case:
The authors report a case of recurrent anterior shoulder instability in a 19-year-old man. Intraoperative arthroscopic examination identified Bankart and engaging Hill-Sachs lesions. The patient was treated with humeral head osteochondral allograft reconstruction and concomitant arthroscopic anterior stabilization. At the 14-year follow-up, there was no recurrent instability.

Conclusion:
Humeral head osteochondral allograft reconstruction combined with an arthroscopic anterior stabilization procedure can be successful for recurrent shoulder instability and engaging Hill-Sachs lesion.
MOBILE HOME FOR PHOLADOID BORING BIVALVES: FIRST EXAMPLE FROM A LATE CRETACEOUS SEA TURTLE IN HOKKAIDO JAPAN
Authors: SATO KEI , JENKINS ROBERT G. 
Published: May 2020

ABSTRACT
Trace fossils preserved in fossilized tissues provide a key resource for exploring the paleoecology of past ecosystems. Endobiont organisms are commonplace in modern ecosystems, but their trace fossils on vertebrates are rare as the organisms usually attack or attach to soft tissue. Here, we report the novel occurrence of flask-shaped boreholes representing the ichnotaxon Karethraichnus n. isp. in the carapace of the basal leatherback sea turtle Mesodermochelys sp. from the Upper Cretaceous of northern Japan. The distribution of the boreholes was determined by observing the carapace surface. Using X-ray computed tomography, we were also able to produce a 3D reconstruction of the whole carapace and examine a cross section of a borehole to analyze the histological aspects of the bone. In total, 43 holes were observed, 12 holes contained probable pholadoid bivalves, and 32 holes were not bored entirely through the carapace. Some of the bivalves found in the holes are larger than the aperture of the hole, suggesting that they continued to grow during boring. The holes are hemispherical to clavate in shape and developed on the exterior side of the carapace. Healing traces, i.e., repairing of bone, can be observed at the surface of the holes. Our observations strongly suggest that these pits were bored by pholadoid bivalves while the turtle was alive. This is the first report of the behavior of boring bivalves as sea-turtle endobionts boring into a unique free-living, i.e., “swimming substrate”.
Large mid-upper arm circumference is associated with metabolic syndrome in middle-aged and elderly individuals: a community-based study
Authors: Shi Jie , Yang Zhen , Niu Yixin , Zhang Weiwei , Li Xiaoyong , Zhang Hongmei , Lin Ning , Gu Hongxia , Wen Jie , Ning Guang , Qin Li , Su Qing 
Published: May 2020

Abstract
Background The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and is a reliable screening measure for identifying individuals with abnormal regional fat distribution. The purpose of this study was to evaluate the association between MUAC and metabolic syndrome (MetS) in middle-aged and elderly individuals. Methods We measured the MUAC in a cross-sectional sample with a total of 9787 subjects aged 40 years and older. The measurement of MUAC is performed on the right arm using a non‐elastic tape held midway between the acromion and the olecranon processes in duplicate, with the arm hanging loosely at the side of the body. The MetS was defined according to the Joint Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Results MUAC was positively correlated with waist circumference (r=0.437, P<0.001), BMI (r=0.334, P<0.001), fasting insulin (r=0.348, P<0.001), HOMA-IR (r=0.134, P< 0.001), triglycerides (r=0.138, P<0.001), SBP (r=0.124, P< 0.001), and DBP (r= 0.123, P<0.001), and inversely correlated with adiponectin (r=-0.147, P < 0.001) and HDL-cholesterol (r=-0.176, P<0.001) after adjusting for age and gender. Compared with the lowest quartile group, the odds ratios were substantially higher for MetS (OR 1.77; 95% CI 1.51-2.09, P for trend<0.001) in the highest MUAC quartile group after adjustment for potential cofounder. Conclusion Large mid-upper arm circumference is significantly associated with metabolic syndrome in middle-aged and elderly individuals .
Identification of an Autophagy-Related Gene Signature that Can Improve Prognosis of Hepatocellular Carcinoma Patients
Authors: Huo Xingxing , Qi Jian , Huang Kaiquan , Bu Su , Yao Wei , Chen Ying , Nie Jinfu 
Published: May 2020

Abstract
Background: Autophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been proposed to play a pivotal role in the progression of hepatocellular carcinoma (HCC).Methods: Univariate Cox regression analysis of overall survival (OS) was performed to identify risk-associated autophagy-related genes (ARGs) in HCC data set from The Cancer Genome Atlas (TCGA). Multivariate cox regression was then performed to develop a risk prediction model for the prognosis of 370 HCC patients. The multi-target receiver operating characteristic (ROC) curve was used to determine the model’s accuracy. Besides, the relationship between drug sensitivity and ARGs expression was also examined.Results: A total of 62 differentially expressed ARGs were identified in HCC patients. Univariate and multivariate regression identified five risk-associated ARGs (HDAC1, RHEB, ATIC, SPNS1 and SQSTM1) that were correlated with OS in HCC patients. Of importance, the risk-associated ARGs were independent risk factors in the multivariate risk model including clinical parameters such as malignant stage (HR=1.433, 95% CI=1.293-1.589, P<0.001). In addition, the area under curve for the prognostic risk model was 0.747, which indicates the high accuracy of the model in prediction of HCC outcomes. Interestingly, the risk-associated ARGs were also correlated with drug sensitivity in HCC cell lines.Conclusions: We developed a novel prognostic risk model by integrating the molecular signature and clinical parameters of HCC, which can effectively predict the outcomes of HCC patients.
The impact of informing diagnosis on quality of life in patients with cancer: A systematic review and meta-analysis
Authors: Wan Miao , Luo Xianggui , Wang Juan , MVOGO Louis.B NDZANA , Chang Chen , Li Zhenfen , Zhang Jianglin 
Published: May 2020

Abstract
Objective To assess the impact of informing diagnosis and disease status on the quality of life in patients with cancer Method We searched the follow databases, Pubmed, CENTRAL(Cochrane Central Register of Controlled Trials), PsycINFO, WEB OF SCIENCE, Embase, CBM (Chinese Biomedical Literature database), WANFANG database (Chinese Medicine Premier), and CNKI (China National Knowledge Infrastructure). And the terms used are as follows: neoplasm, cancer, tumour, tumor, carcinoma, disclosure, truth telling, breaking bad news, knowledge, knowing, awareness, quality of life, QOL. Pairs of reviewers independently screened documents and extracted the data. Meta-analysis was conducted by Revman 5.0 software. Results There were 11740 records retrieved from databases and 23 studies were included finally. Meta-analysis of informed and uniformed cancer patients revealed no differences in both the general quality of life and symptoms of fatigue, pain, dyspnea, insomnia, appetite loss and diarrhea (P>0.05). Additionally, no difference in physical function, role function, cognitive activity and emotional function between the above 2 groups(P>0.05) were found. On the vitality area, the patients who were totally informed about their diagnosis had higher vitality than the uniformed patients. However, patients aware about their illnesses seemed to get lower scores in social function. Between the partly informed of the diagnosis and uninformed cancer patients, there were no differences in general quality of life, function domains and disease-related symptoms (P>0.05). Conclusion Informing the cancer patients their diagnosis may not have a bad effect on their quality of life. PROSPERO registration number CRD42017060073.
Overexpression of IκBα in cardiomyocytes alleviates hydrogen peroxide-induced apoptosis and autophagy through inhibiting NF-κB activation
Authors: Han Min , Chen Xiao-Cui , Sun Ming-Hui , Gai Min-Tao , Yang Yi-Ning , Gao Xiao-Ming , Ma Xiang , Chen Bang-Dang , Ma Yi-Tong 
Published: May 2020

Abstract
Background: Inflammation and oxidative stress play a predominant role in the initiation and progression of ischemia/reperfusion (I/R) injury, of which nuclear factor kappa B (NF-κB) is a crucial mediator. Overexpression of the inhibitor of κB alpha (IκBα) gene is hypothesized to have protective effects against apoptosis and autophagy in cardiomyocytes subjected to hydrogen peroxide (H2O2) through inhibiting the NF-κB pathway.Methods: The IκBαS32A, S36A gene was transfected via adeno-associated virus serotype 9 (AAV9) delivery into neonatal rat ventricular cardiomyocytes (NRVMs) prior to H2O2 treatment. NRVMs were divided into control, H2O2, GFP +H2O2, IκBα+H2O2, and pyrrolidine dithiocarbamate (PDTC)+H2O2 groups. Nuclear translocation of NF-κB p65 subunit was evaluated by immunofluorescence and Western blot. Cell viability was assessed by Cell Counting Kit-8 assay. Supernatant lactate dehydrogenase (LDH) and intracellular malondialdehyde (MDA) were measured to identify H2O2-stimulated cytotoxicity. Apoptosis was determined by Annexin V-PE/7-AAD staining, and the mitochondrial membrane potential (ΔΨm) was detected by JC-1 staining. Western blot was used to detect apoptosis- and autophagy-related proteins.Results: IκBα transfection significantly increased cell viability and ΔΨm, but decreased the supernatant LDH and cellular MDA levels in cardiomyocytes exposed to H2O2. Meanwhile, IκBα overexpression decreased H2O2-induced apoptosis by upregulating the Bcl-2/Bax ratio and reduced autophagy by downregulating the expression of Beclin-1 and the LC3-Ⅱ/LC3-Ⅰ ratio. These effects partly accounted for the ability of IκBα to inhibit the NF-κB signaling pathway, as evidenced by decreases in p65 phosphorylation and nuclear translocation. Indeed, the effects of inactivation of NF-κB signaling with the specific inhibitor, PDTC, resembled the cardioprotective effects of IκBα during H2O2 stimulation.Conclusion: IκBα overexpression can ameliorate H2O2-induced apoptosis, autophagy, oxidative injury, and ΔΨm loss through inhibition of the NF-κB signaling pathway. These findings suggest that IκBα transfection can successfully resist oxidative stress-induced damage through inhibiting NF-κB activation, which may provide a potential therapeutic target for prevention of myocardial I/R injury.
The Impact of an Audience Response System on a summative Assessment, a controlled Field Study
Authors: Schmidt Thorsten , Gazou Anastasia , Riess Angelika , Riess Olaf , Grundmann-Hauser Kathrin , Falb Ruth , Schadeck Malou , Heinrich Tilman , Abeditashi Mahkameh , Schmidt Jana , Mau-Holzmann Ulrike , Schnabel Kai 
Published: May 2020

Abstract
Background Audience response systems allow to activate the audience and to receive a direct feedback of participants during lectures. Modern systems do not require any proprietary hardware anymore. Students can directly respond on their smartphone. Several studies reported about a high level of satisfaction of students when audience response systems are used, however their impact on learning success is still unclear. Methods In order to evaluate the impact of an audience response system on the learning success we implemented the audience response system eduVote into a seminar series and performed a controlled crossover study on its impact on assessments. 154 students in nine groups were taught the same content. In four groups, eduVote was integrated for the first topic while five groups were taught this topic without the audience response systems. For a second topic, the groups were switched: Those groups who were taught before using eduVote were now taught without the audience response system and vice versa. We then analysed the impact of the audience response system on the students’ performance in a summative assessment and specifically focused on questions dealing with the topic, for which the audience response system was used during teaching. We further assessed the students’ perception on the use of eduVote using questionnaires. Results In our controlled crossover study we could not confirm an impact of the audience response system eduVote on long-term persistence i.e. the students’ performance in the summative assessment. Our evaluation revealed that students assessed the use of eduVote very positively, felt stronger engaged and better motivated to deal with the respective topics and would prefer their integration into additional courses as well. In particular we identified that students who feel uncomfortable with answering questions in front of others profit from the use of an audience response system during teaching. Conclusions Audience response systems motivate and activate students and increase their engagement during classes. However, their impact on long-term persistence and summative assessments may be limited. Audience response systems, however, specifically allow activating students which cannot be reached by the traditional way of asking questions without such an anonymous tool.
Malaria outbreak investigation in a rural area south of Zimbabwe: a case-control study
Authors: Mundagowa Paddington Tinashe , Chimberengwa Pugie T. 
Published: May 2020

Abstract
Background Ninety percent of the global annual malaria mortality cases emanate from the African region. About 80-90% of malaria transmissions in sub-Saharan Africa occur indoors during the night. In Zimbabwe, 79% of the population are at risk of contracting the disease. Although the country has made significant progress towards malaria elimination, isolated seasonal outbreaks persistently resurface. In 2017, Beitbridge District was experiencing a second malaria outbreak within twelve months prompting the need for investigating the outbreak.Methods An unmatched 1:1 case-control study was conducted to establish the risk factors associated with contracting malaria in Ward 6 of Beitbridge District from week 36 to week 44 of 2017. The sample size constituted of 75 randomly selected cases and 75 purposively selected controls. Data were collected using an interviewer-administered questionnaire and Epi Info version 7.2.1.0 was used to conduct descriptive, bivariate and multivariate analyses of the factors associated with contracting malaria.Results Fifty-two percent of the cases were females and the mean age of cases was 29±13 years. Cases were diagnosed using rapid diagnosed tests. Sleeping in a house with open eaves (OR: 2.97; 95%CI: 1.44-6.16; p<0.01), spending the evenings outdoors (OR: 2.24; 95%CI: 1.04-4.85; p=0.037) and sleeping in a poorly constructed house (OR: 4.33; 95%CI: 1.97-9.51; p<0.01) were significantly associated with contracting malaria while closing eaves was protective (OR:0.45; 95%CI: 0.20-1.02; p=0.055). After using backward stepwise logistic regression, sleeping in a poorly constructed house was associated with five-fold odds of getting sick from malaria (AOR: 8.40 ; 95%CI: 1.69-41.66; p=0.009). Those who had mosquito nets did not use them consistently. The district health team and the rural health center were well prepared to response despite having limited human resources.Conclusion Health promotion messages should emphasize the importance of closing the entry points of the malaria vector, and the construction of better houses in the future. Residents had to be educated in the importance of consistent use of mosquito nets. The district had to improve malaria preventive measures like distribution of mosquito nets and lobby for more human resources to assist with malaria surveillance thus, curbing the recurrence of malaria outbreaks.
Dissection of the genetic basis of oil content in Chinese peanut cultivars through association mapping
Authors: Liu Nian , Huang Li , Chen Weigang , Wu Bei , Pandey Manish K. , Luo Huaiyong , Zhou Xiaojing , Guo Jianbin , Chen Haiwen , Huai Dongxin , Chen Yuning , Lei Yong , Liao Boshou , Ren Xiaoping , Varshney Rajeev K. , Jiang Huifang 
Published: May 2020

Abstract
Background: Peanut is one of the primary sources for vegetable oil worldwide, and enhancing oil content is the main objective in several peanut breeding programs of the world. Tightly linked markers are required for faster development of high oil content peanut varieties through genomics-assisted breeding (GAB), and association mapping is one of the promising approaches for discovery of such associated markers. Results: An association mapping panel consisting of 292 peanut varieties extensively distributed in China was phenotyped for oil content and genotyped with 583 polymorphic SSR markers. These markers amplified 3663 alleles with an average of 6.28 alleles per locus. The structure, phylogenetic relationship, and principal component analysis (PCA) indicated two subgroups majorly differentiating based on geographic regions. Genome-wide association analysis identified 12 associated markers including one (AGGS1014_2) highly stable association controlling up to 9.94% phenotypic variance explained (PVE) across multiple environments. Interestingly, the frequency of the favorable alleles for 12 associated markers showed a geographic difference. Two associated markers (AGGS1014_2 and AHGS0798) with 6.90-9.94% PVE were verified to enhance oil content in an independent RIL population and also indicated selection during the breeding program. Conclusion: This study provided insights into the genetic basis of oil content in peanut and verified highly associated two SSR markers to facilitate marker-assisted selection for developing high-oil content breeding peanut varieties.