bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cover crop diversity for weed suppression and crop yield in a corn–soybean production system in Tennessee
Authors: Sabbagh Manuel J. , Jagadamma Sindhu , Duncan Lori A. , Walker Forbes R. , Lee Jaehoon , Essington Michael E. , Arelli Prakash , Buschermohle Michael J. 
Published: November 2020

AbstractWeed communities may potentially reduce row‐crop yields resulting in a loss of revenue for producers. Studies have reported a decrease in the efficacy of chemical methods of weed control due to increased weed resistance. With the goal of reducing reliance on chemical weed control and promoting sustainable crop production in mind, we evaluated different winter cover crop (CC) types (single‐, double‐, and multi‐species) and CC planting methods (broadcasting vs. drilling) on CC and weed groundcover and row‐crop yield in a no‐till corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] rotation system in Tennessee from 2013 to 2017. Our results showed that winter CC reduced spring weed ground coverage by 64–76% compared with winter fallow with no herbicide application. A five‐species CC mixture increased soybean yields by 6 to 8.5% across seeding method treatments compared with other CC treatments and winter fallow. This yield increase was more visible in a drought year. Corn, grown in years with normal weather patterns, did not show a yield response to CC types. From this study, cover cropping was found to be an effective strategy for weed control compared with leaving the field fallow without herbicide application following row‐crop harvest; however, no consistent species‐specific trends were observed on weed suppression and row‐crop yield. Future research should focus on understanding CC species composition and biomass production in double‐ and multi‐species mixtures from this field experiment to draw robust conclusions on agronomic responses of individual CC species and planting methods.
Autosomal‐dominant WFS1‐related disorder—Report of a novel WFS1 variant and review of the phenotypic spectrum of autosomal recessive and dominant forms
Authors: Abu‐El‐Haija Aya , McGowan Caroline , Vanderveen Deborah , Bodamer Olaf 
Published: November 2020

AbstractWolfram syndrome was initially reported as an autosomal recessive (AR), progressive neurodegenerative disorder that leads to diabetes insipidus, childhood onset diabetes mellitus (DM), optic atrophy, and deafness (D) also known as DIDMOAD. However, heterozygous dominant pathogenic variants in Wolfram syndrome type 1 (WFS1) may lead to distinct, allelic conditions, described as isolated sensorineural hearing loss (SNHL), syndromic SNHL, congenital cataracts, or early onset DM. We report a family with a novel dominant, likely pathogenic variant in WFS1 (NM_006005.3) c.2605_2616del12 (p.Ser869_His872del), resulting in cataracts, SNHL, and DM in a female and her mother. A maternal aunt had cataracts, DM, and SNHL but was not tested for the familial WFS1 mutation. Both the mother and maternal aunt had early menopause by age 43 years and infertility which may be a coincidental finding that has not been associated with autosomal dominant AD WFS1‐related disorder to the best of our knowledge. Screening at risk individuals in families with the AR Wolfram syndrome, for DM, SNHL, and for cataracts is indicated.
Association between biphasic reactions and the systems of symptoms and treatment in patients with anaphylaxis hospitalized from the emergency department
Authors: Nomura Tomohisa , Sekii Hajime , Sugita Manabu , Nakahara Shinji 
Published: November 2020

AimAnaphylaxis is a severe, life‐threatening, generated or systemic reaction, and biphasic reaction could occur in some cases. We investigated the clinical course of anaphylaxis in our hospital and studied the relationship between biphasic reactions and the symptoms and treatments for predicting the onset of biphasic reactions.MethodsWe retrospectively reviewed the medical records of 120 patients with anaphylaxis who were admitted to our hospital from the emergency department during April 2008–October 2015.ResultsThe incidence of biphasic reactions of anaphylaxis in our hospital was 10.8% (13 patients) without significant difference when compared with that in previous reports. Regarding the development of biphasic reactions, symptoms, the number of systems of symptoms and severity of the initial reaction, and treatment with adrenaline and corticosteroid were not clearly related with biphasic reaction. Use of adrenaline in the initial treatment was approximately 60%. Of the 13 biphasic reactions, 11 (84.5%) were as equal/mild as the original symptoms.ConclusionThis study could not show the factors predicting the onset of biphasic reactions. Further prospective and nationwide studies are required to research biphasic reactions.
Novel bilayer electrospun poly(caprolactone)/ silk fibroin/ strontium carbonate fibrous nanocomposite membrane for guided bone regeneration
Authors: Etemadi Niloofar , Mehdikhani Mehdi , Poorazizi Elahe , Rafienia Mohammad 
Published: November 2020

AbstractIn this study, a thin layer with a thickness of about 120 μm of poly(caprolactone) (PCL) was fabricated by electrospinning method. Then, a fibrous nanocomposite composed of PCL/silk fibroin/strontium carbonate (PCL/SF/SrCO3) was electrospun on the prepared layer. Then, they were characterized. The mechanical properties, water uptake, degradation rate, wettability, porosity, and bioactivity of the electrospun membrane were scrutinized in vitro. Cytotoxicity of the samples was assessed by using osteoblast‐like cells (SAOS‐2) and L929 fibroblasts. Moreover, the cell adhesion, alkaline phosphatase (ALP) activity, and calcium deposition through alizarin red staining were conducted. Results revealed that the bilayer structure doubled the optimum mechanical properties and the addition of SrCO3 up to 15%–20% increased ALP activity, calcium deposition, and bioactivity. According to the results, the nanofibrous bilayer membrane containing 20 wt% SrCO3, 20 wt% SF, and 60 wt% PCL was chosen as the optimum sample. Therefore, this membrane could be applied in guided bone regeneration (GBR).
Using Chemical Inventory Data to Prepare Against Source Water Contamination
Authors:   AWWA Source Water Protection Committee
Published: November 2020

Key TakeawaysIf community water systems can easily access information about hazardous chemical storage in their source water protection area (SWPA) and know how to make full use of the data, they stand a better chance of sufficiently preparing for source water emergencies.Required under the Emergency Planning and Community Right‐to‐Know Act, annual Tier II reports contain valuable information about specific hazardous chemicals that are stored or used in SWPAs.Provisions in America's Water Infrastructure Act of 2018 give community water systems a legal right to Tier II hazardous chemical inventory data for facilities in their SWPA, which can be used to promote comprehensive source water protection planning.
Derivatization‐based quadruplex LC/ESI–MS/MS method for high throughput quantification of serum dehydroepiandrosterone sulfate
Authors: Aso Saki , Ogawa Shoujiro , Nishimoto‐Kusunose Shoichi , Satoh Mamoru , Ishige Takayuki , Nomura Fumio , Higashi Tatsuya 
Published: November 2020

AbstractThe quantification of the circulating dehydroepiandrosterone sulfate (DHEAS) might be of diagnostic help for several diseases. For the DHEAS quantification, LC/ESI–MS/MS has the advantage of a high specificity compared with immunoassay, whereas LC/ESI–MS/MS has room to improve the analysis throughput. One of the promising solutions to enhance the analysis throughput is sample‐multiplexing in the same injection, which can reduce the total LC/ESI–MS/MS run time. In this study, a quadruplex LC/ESI–MS/MS method was developed to quantify DHEAS in four different serum samples in a single run. After the four samples were separately deproteinized and derivatized with one of four Girard reagents (Girard reagent T, P and their isotopologs), the resulting samples were mixed, then injected into the LC/ESI–MS/MS. The applicability and advantage of the developed method were evaluated based on the analysis of nine batches of serum samples from healthy subjects (total 36 samples). The limit of quantitation was 0.050 μg/ml, which was sensitive enough for clinical laboratory use. The method was precise (intra‐ and inter‐assay RSDs ≤ 3.6%), accurate (94.4–108.1%) and robust for the matrix effects. The analysis time was also shortened by about 60% for 36 samples by the introduced method compared with the conventional method.
Validating the Essen Climate Evaluation Schema modified for people with learning disabilities in a low‐risk secure forensic setting
Authors: Barker Lindsie , McKeown Annette , Small Michelle , Meggs Jenny 
Published: November 2020

AbstractBackgroundResearch has shown that an empowering and nurturing yet challenging work climate is beneficial for people receiving clinical services as it increases patient satisfaction, motivation, engagement, therapeutic alliance and functional improvement. Therefore, for inpatients, monitoring, encouraging and understanding ward climate holds considerable potential for improving forensic mental health services. To date, the most widely employed tool for ward‐climate, the Essen Climate Evaluation Schema (EssenCES), has been evidenced as useful in medium and high security hospitals, but little tested with people with learning disabilities or in low security services.AimsTo establish the internal consistency and factor validity of the EssenCES, modified for easier reading, in a low secure hospital unit for people with learning disabilities.MethodLanguage in the EssenCES was simplified and picture supplements added to facilitate comprehension. Patients completed the scale as part of their clinical routine, supported by National Health Service (NHS) employed psychology assistants. The research team, entirely independent of NHS staff, extracted data from the electronic records of purposively sampled residents in a low‐secure forensic hospital setting for people with learning disabilities.FindingsTwo hundred and twenty‐seven records (70% men) were acquired. The EssenCES was shown to have good factor validity and retained the original three factor model including the subscales: therapeutic hold, safety and cohesion. One single‐item from the ‘therapeutic hold’ subscale was removed to improve the internal consistency (p < 0.05).ConclusionsThis study adds preliminary support for the use of the EssenCES (with removal of one item) in individuals with learning disabilities within low‐risk secure forensic hospital settings.
Long‐term clinical outcomes after self‐expandable bare nitinol stent implantation for femoropopliteal occlusive disease in hemodialysis patients
Authors: Ito Ryuta , Ishii Hideki , Oshima Satoru , Nakayama Takuya , Takahashi Hiroshi , Sakakibara Takashi , Kakuno Motohiko , Murohara Toyoaki 
Published: November 2020

AbstractObjectivesTo compare the long‐term clinical outcomes after self‐expandable bare nitinol stent (BNS) implantation between hemodialysis (HD) and non‐HD patients with femoropopliteal (FP) disease.BackgroundAlthough a BNS has been commonly used in patients with FP disease, the long‐term efficacy of BNSs in HD patients remains unknown.MethodsIn total, 427 HD patients treated with a BNS for FP disease were enrolled, along with 157 non‐HD patients as a control group. Over the following 5 years, the incidence of target lesion revascularization (TLR), major amputation and mortality was investigated. We also performed propensity‐score matching analysis.ResultsThe 5‐year TLR rate (45.2 vs. 32.5%, p = .013) and mortality rate (39.3 vs. 14.0%, p = .0002) were significantly higher in the HD group than in the non‐HD group. The major amputation rate was comparable between the groups (7.2% in the HD group vs. 2.8% in the non‐HD group, p = .16). In the propensity‐score‐matched cohort, the TLR rate, and mortality rate were remained higher in the HD group than in the non‐HD group (48.9 vs. 34.1%, hazard ratio [HR] 2.11, 95% confidence interval [CI] 1.30–3.49, p = .0024, and 47.9 vs. 12.0%, HR 3.38, 95% CI 1.86–6.56, p < .0001, respectively). The adjusted amputation rate was consistently similar between the groups (1.7% in the HD group vs. 2.7% in the non‐HD group, HR 0.90, 95% CI 0.26–2.99, p = .86).ConclusionsThe TLR rate and mortality at 5 years post BNS implantation for FP disease were significantly higher in HD patients than in non‐HD patients, though the limb salvage rate was similar.
Long‐term outcomes after transcatheter aortic valve replacement with minimal contrast in chronic kidney disease
Authors: Rzucidlo Justyna , Jaspan Vita , Paone Darien , Jilaihawi Hasan , Xia Yuhe , Kapitman Anna , Nakashima Makoto , He Yuxin , Ibrahim Homam , Pushkar Illya , Neuburger Peter J. , Saric Muhamed , Bamira Daniel , Paschke Sonja , Kalish Chloe , Staniloae Cezar , Shah Binita , Williams Mathew 
Published: November 2020

AbstractBackgroundPatients with renal insufficiency have poor short‐term outcomes after transcatheter aortic valve replacement (TAVR).MethodsRetrospective chart review identified 575 consecutive patients not on hemodialysis who underwent TAVR between September 2014 and January 2017. Outcomes were defined by VARC‐2 criteria. Primary outcome of all‐cause mortality was evaluated at a median follow‐up of 811 days (interquartile range 125–1,151).ResultsPreprocedural glomerular filtration rate (GFR) was ≥60 ml/min in 51.7%, 30–60 ml/min in 42.1%, and < 30 ml/min in 6.3%. Use of transfemoral access (98.8%) and achieved device success (91.0%) did not differ among groups, but less contrast was used with lower GFR (23 ml [15–33], 24 ml [14–33], 13 ml [8–20]; p < .001). Peri‐procedural stroke (0.7%, 2.1%, 11.1%; p < .001) was higher with lower GFR. Core lab analysis of preprocedural computed tomography scans of patients who developed a peri‐procedural stroke identified potential anatomic substrate for stroke in three out of four patients with GFR 30–60 ml/min and all three with GFR <30 ml/min (severe atheroma was the most common subtype of anatomical substrate present). Compared to GFR ≥60 ml/min, all‐cause mortality was higher with GFR 30–60 ml/min (HR 1.61 [1.00–2.59]; aHR 1.61 [0.91–2.83]) and GFR <30 ml/min (HR 2.41 [1.06–5.48]; aHR 2.34 [0.90–6.09]) but not significant after multivariable adjustment. Follow‐up echocardiographic data, available in 63%, demonstrated no difference in structural heart valve deterioration over time among groups.ConclusionsPatients with baseline renal insufficiency remain a challenging population with poor long‐term outcomes despite procedural optimization with a transfemoral‐first and an extremely low‐contrast approach.
One‐year clinical and echocardiographic outcomes of direct implantation of a self‐expanding valve
Authors: Benetos Georgios , Karmpalioti Maria , Drakopoulou Maria , Stathogiannis Konstantinos , Xanthopoulou Maria , Latsios George , Synetos Andreas , Bei Evangelia , Voudris Vassilis , Iakovou Ioannis , Katsimagklis Georgios , Moraitis Sotiris , Zeniou Vicki , Danenberg Haim , Halvatsiotis Panagiotis , Vavuranakis Manolis , Tousoulis Dimitris , Toutouzas Konstantinos 
Published: November 2020

AbstractObjectiveTo present 1 year clinical and echocardiographic outcomes of the randomized DIRECT (Pre‐dilatation in Transcatheter Aortic Valve Implantation Trial) trial.BackgroundIntermediate‐term data from randomized studies investigating the safety and efficacy of direct implantation are lacking.MethodsDIRECT trial randomized 171 consecutive patients with severe aortic stenosis at four tertiary centers to undergo TAVI with the use of self‐expanding prostheses with (pre‐BAV) or without pre‐dilatation (no‐BAV). The primary endpoint was device success according to the VARC‐2 criteria. All patients underwent a clinical and echocardiographic follow‐up at 1 year. All‐cause and cardiac mortality, stroke, heart failure hospitalization, and new pacemaker implantation were recorded.ResultsAt 1 year, four deaths were recorded in pre‐BAV group (4.7%) and three deaths in no‐BAV group (3.5%). There was no difference in Kaplan–Meier plots between the two groups in all‐cause mortality at 1 year (log‐rank p = .72). Similarly, there was no difference in the incidence of permanent pacemaker implantation between the two groups at 1 year (27/67–40.3% in no‐BAV group versus 20/69–29% in pre‐BAV group, log‐rank p = .24). There was no significant difference between pre‐BAV and no BAV group in aortic valve area (1.84 ± 0.39 cm2 vs. 1.85 ± 0.44 cm2, p = .90), mean aortic valve gradient (8.36 ± 5.04 vs. 8.00 ± 4.04 mmHg, p = .65) and moderate or severe paravalvular regurgitation (5–6.6 vs. 4–5.7%, respectively) at 1 year. The same applied independently from the performance of post‐dilatation at baseline.ConclusionsDirect, without pre‐dilatation, implantation of a self‐expanding valve has no impact on one‐year clinical and echocardiographic outcomes, independently also from the baseline performance of post‐dilatation.
TFE3 activation in a TSC1‐altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms
Authors: Schmiester Maren , Dolnik Anna , Kornak Uwe , Pfitzner Berit , Hummel Michael , Treue Denise , Hartmann Arndt , Agaimy Abbas , Weyerer Veronika , Lekaj Anja , Brakemeier Susanne , Peters Robert , Öllinger Robert , Märdian Sven , Bullinger Lars , Striefler Jana Käthe , Flörcken Anne 
Published: November 2020

AbstractPerivascular epithelioid cell tumors (PEComas) form a family of rare mesenchymal neoplasms that typically display myomelanocytic differentiation. Upregulation of mTOR signaling due the inactivation of TSC1/2 (Tuberous Sclerosis 1 and 2) is believed to be a key oncogenic driver in this disease. Recently, a subgroup of PEComas harboring TFE3 (Transcription Factor E3) rearrangements and presenting with a distinctive morphology has been identified. TSC1/2 and TFE3 aberrations are deemed to be mutually exclusive in PEComa, with two different pathogenic mechanisms assumed to lead to tumorigenesis. Here, we challenge this dichotomy by presenting a case of a clinically aggressive TCS1‐mutated PEComa displaying a TFE3‐altered phenotype. FISH analysis was suggestive of a TFE3 inversion; however, RNA and whole genome sequencing was ultimately unable to identify a fusion involving the gene. However, a copy number increase of the chromosomal region encompassing TFE3 was detected and transcriptome analysis confirmed upregulation of TFE3, which was also seen at the protein level. Therefore, we believe that the TSC1/2‐mTOR pathway and TFE3 overexpression can simultaneously contribute to tumorigenesis in PEComa. Our comprehensive genetic analyses add to the understanding of the complex pathogenic mechanisms underlying PEComa and harbor insights for clinical treatment options.
Continuous monitoring of sleep‐disordered breathing with pacemakers: Indexes for risk stratification of atrial fibrillation and risk of stroke
Authors: Mazza Andrea , Bendini Maria Grazia , Leggio Massimo , De Cristofaro Raffaele , Valsecchi Sergio , Boriani Giuseppe 
Published: November 2020

AbstractBackgroundSleep apnea (SA) is a risk factor for atrial fibrillation (AF). Advanced pacemakers are now able to calculate indexes of SA severity.HypothesisWe investigated the changes in pacemaker‐measured indexes of SA, we assessed their predictive value for AF occurrence and the associated risk of stroke and death at long‐term.MethodsWe enrolled 439 recipients of a pacemaker endowed with an algorithm for the calculation of a Respiratory Disturbance Index (RDI). The RDI variability was measured over the first 12 months after implantation, as well as its potential association with the occurrence of AF, defined as device‐detected cumulative AF burden ≥6 hoursours in a day.ResultsThe individual RDI mean was 30 ± 18 episodes/h, and the RDI maximum was 59 ± 21 episodes/h. RDI ≥30 episodes/h was detected in 351 (80%) patients during at least one night. The proportion of nights with RDI ≥30 episodes/h was 14% (2%‐36%). AF ≥6 hours was detected in 129 (29%) patients during the first 12 months. The risk of AF was higher in patients with RDI maximum ≥63 episodes/h (HR:1.74; 95%CI: 1.22‐2.48; P = .001) and with RDI mean ≥ 46 episodes/h (HR:1.63; 95%CI: 1.03‐2.57; P = .014). The risk of all‐cause death or stroke was higher in patients with AF burden ≥6 hours (HR:1.75; 95%CI: 1.06‐2.86; P = .016). Moreover, among patients with no previous history of AF the risk was higher in those with RDI maximum ≥63 episodes/h (HR:1.96; 95%CI: 1.06‐3.63; P = .031).ConclusionsPacemaker‐detected SA showed a considerable variability during follow‐up. We confirmed the association between RDI and higher risk of AF, and we observed an association between higher RDI maximum and all‐cause death or stroke among patients with no previous history of AF.
Personalized networks of eating disorder symptoms predicting eating disorder outcomes and remission
Authors: Levinson Cheri A. , Cash Elizabeth , Welch Karla , Epskamp Sacha , Hunt Rowan A. , Williams Brenna M. , Keshishian Ani C. , Spoor Samantha P. 
Published: November 2020

AbstractEnhanced cognitive–behavioral therapy (CBT‐E) is one of the primary evidence‐based treatments for adults with eating disorders (EDs). However, up to 50% of individuals do not respond to CBT‐E, likely because of the high heterogeneity present even within similar diagnoses. This high heterogeneity, especially in regard to presenting pathology, makes it difficult to develop a treatment based “on averages” and for clinicians to accurately pinpoint which symptoms should be targeted in treatment. As such, new models based at both the group, and individual level, are needed to more accurately refine targets for personalized evidence‐based treatments that can lead to full remission. The current study (Expected N = 120 anorexia nervosa, atypical anorexia nervosa, and bulimia nervosa) will build both group and individual longitudinal models of ED behaviors, cognitions, affect, and physiology. We will collect data for 30 days utilizing a mobile application to assess behaviors, cognition, and affect and a sensor wristband that assesses physiology (heart rate, acceleration). We will also collect outcome data at 1‐ and 6‐month follow‐ups to assess ED outcomes and remission status. These data will allow for identification of “on average” and “individual” targets that maintain ED pathology and test if these targets predict outcomes, including ED remission.