bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence estimates of voiding disorders in Turkish school‐age children
Authors: Kaplan Fatih , Tabel Yılmaz , Elmas Ahmet Taner 
Published: October 2020

AbstractObjectivesThis study aims to investigate the prevalence of voiding disorders and identify the associated risk factors for school‐age children in East Anatolia, Turkey.MethodsWe randomly selected six primary schools in Malatya in East Anatolia, and 907 students from 6 to 14 years old were involved. Data were obtained using the dysfunctional voiding and incontinence scoring system (DVISS) scale, and children who scored 8.5 or above on that scale were considered as having voiding disorders.ResultsVoiding disorders were detected in 175 (19.2%) of 907 children. One hundred and fifty‐two (16.8%) had day‐time urinary incontinence, and 131 (14.5%) had night‐time incontinence. The findings showed a significant relationship between voiding disorder and daytime/night‐time incontinence, and fecal incontinence. Voiding disorders decreased as the age increased. There was a significant relationship between voiding disorder and positive family history, and the quality of life of these children was significantly affected.ConclusionVoiding disorder is a common disease among school‐age children. By identifying and treating voiding disorders and related risk factors in children in the early period, these children can be protected from possible medical or social complications.
Single‐chamber leadless pacemaker for atrial synchronous or ventricular pacing
Authors: Hai Jo‐Jo , Chan Yap‐Hang , Lau Chu‐Pak , Tse Hung‐Fat 
Published: October 2020

AbstractLeadless pacing is a major breakthrough in the management of bradyarrhythmia. Results of initial clinical trials that have demonstrated a significant reduction in acute and long‐term pacing‐related complications have been confirmed by real‐world experience in a broader spectrum of patients. Nonetheless current use of a leadless pacemaker is hampered by its limited atrial sensing and pacing capability, as well as battery life‐span and retrievability. We review the current clinical outcome data, indications and contraindications, implantation and retrieval techniques, synchronous ventricular pacing, and other clinical considerations. We also provide an overview of the latest advancements in leadless pacing technology including device‐to‐device communication and energy harvesting technology.
Strategies in DNA vaccine for melanoma cancer
Authors: Rezaei Tayebeh , Davoudian Elham , Khalili Saeed , Amini Mohammad , Hejazi Maryam , de la Guardia Miguel , Mokhtarzadeh Ahad 
Published: October 2020

AbstractAccording to reports of the international agency for cancer on research, although malignant melanoma shows less prevalence than nonmelanoma skin cancers, it is the major cause of skin cancer mortality. Given that, the production of effective vaccines to control melanoma is eminently required. In this regard, DNA‐based vaccines have been extensively investigated for melanoma therapy. DNA vaccines are capable of inducing both cellular and humoral branches of immune responses. These vaccines possess some valuable advantages such as lack of severe side effects and high stability compared to conventional vaccination methods. The ongoing studies are focused on novel strategies in the development of DNA vaccines encoding artificial polyepitope immunogens based on the multiple melanoma antigens, the inclusion of molecular adjuvants to increase the level of immune responses, and the improvement of delivery approaches. In this review, we have outlined the recent advances in the field of melanoma DNA vaccines and described their implications in clinical trials as a strong strategy in the prevention and control of melanoma.
Development of Acanthocheilonema viteae in Meriones shawi: Absence of microfilariae and production of active ES‐62
Authors: Lumb Felicity E. , Doonan James , Corbet Marlene , Pineda Miguel A. , M. Harnett Margaret , Harnett William 
Published: October 2020

AbstractAimsES‐62 is a well‐studied anti‐inflammatory molecule secreted by L4‐adult stage Acanthocheilonema viteae. We maintain the life cycle of A viteae using Meriones libycus as the definitive host. Here, we investigated whether the full life cycle could be maintained, and functional ES‐62 produced, in a related jird species—Meriones shawi.Methods and ResultsAdult worms were produced in comparable numbers in the two species, but very few microfilariae (MF) were observed in the M shawi bloodstream. M shawi ES‐62 produced ex vivo was functional and protective in a mouse model of arthritis. Myeloid‐derived cells from naïve and infected jirds of both species were compared with respect to ROS production and osteoclast generation, and some differences between the two species in both the absence and presence of infection were observed.ConclusionsThe life cycle of A viteae cannot be successfully completed in M shawi jirds but L3 stage worms develop to adulthood and produce functional ES‐62. Preliminary investigation into jird immune responses suggests that infection can differentially modulate myeloid responses in the two species. However, species‐specific reagents are required to understand the complex interplay between A viteae and its host and to explain the lack of circulating MF in infected M shawi jirds.
Transfusion‐related Epstein‐Barr virus (EBV) infection: A multicenter prospective cohort study among pediatric recipients of hematopoietic stem cell transplants (TREASuRE study)
Authors: Enok Bonong Pascal R. , Buteau Chantal , Delage Gilles , Tanner Jerome E. , Lacroix Jacques , Duval Michel , Laporte Louise , Tucci Marisa , Robitaille Nancy , Spinella Philip C. , Cuvelier Geoffrey , Vercauteren Suzanne , Lewis Victor , Fearon Margaret , Drews Steven J , Alfieri Carolina , Trottier Helen 
Published: October 2020

AbstractBackgroundEpstein‐Barr virus (EBV) is carried in the blood of most adults, and transfusion‐related infections have been reported. EBV is particularly deleterious in immunosuppressed transplant patients. The aim was to determine if EBV transmission occurred through leukodepleted blood product transfusion in pediatric recipients of hematopoietic stem cell transplants (HSCT).Study Design and MethodsThis prospective Canadian multi‐center cohort study includes 156 allogeneic HSCT pediatric recipients. The association between EBV and transfusion was analyzed using Cox regressions. EBV infection, defined by a PCR+ test in the blood of seronegative recipients of an EBV‐negative graft, was monitored in order to correlate the recipient EBV strain with that of the blood donors. EBV genotypes were determined by PCR amplification followed by DNA sequencing at two loci (EBNA3b and LMP1).ResultsNo statistically significant associations were found between transfusions and EBV. One case of post‐transplant EBV infection was identified among the 21 EBV‐seronegative recipients receiving an EBV‐negative graft. A total of 22 blood donors were retraced to determine whether the recipientʼs EBV strain matched that of a donor. One donor strain showed 100% sequence homology at the EBNA3b locus, but differed by one or two point mutations and by a 132‐bp deletion at the LMP1 locus. The blood donor in question was alone among the 22 donors to show amplifiable virus in plasma. Blood from this donor readily produced an immortalized lymphoblastoid cell line in culture.ConclusionWhile considered a rare event, EBV transmission through transfusion may occur in the context of severe immunosuppression.
Trade liberalisation and Chinese firm’s exports: Sourcing from Indonesia
Authors: Ing Lili Yan , Tian Wei , Yu Miaojie 
Published: October 2020

AbstractWe investigate how trade liberalisation affects the performance of Chinese manufacturing firms via sourcing from the South. Taking imports from Indonesia, the largest country in South‐east Asia—China's current trading partner as an example, we find that Chinese firms with higher import shares from Indonesia perform better in productivity, exports and sales, and they are more likely to engage in processing exports. Moreover, the impacts of foreign trade liberalisation on China's export scopes are more pronounced for firms with larger import shares from Indonesia. Such findings are robust to different empirical specifications.
An Orthotic Joint Design for Enhancing Ankle Mobility With Ankle Foot Orthoses Use
Authors: Baker Eileen , Voglewede Philip , Current Thomas , Silver-Thorn Barbara 
Published: October 2020

Abstract
Articulated ankle foot orthoses (AFOs) are prescribed to treat drop-foot, a common neuromuscular weakness observed after a stroke. These assistive devices prevent the toe from dragging during swing (drop-foot) by providing a resistive moment at the ankle. However, existing ankle joint designs for articulated AFOs introduce additional gait pathologies as they also constrain ankle mobility during stance. A novel ankle joint for AFOs to prevent drop-foot during swing and improve ankle mobility during stance was developed, thereby reducing compensatory knee motion during stance. The design intent was to mimic the unconstrained kinematic response of a nonpathologic ankle at initial contact while preventing drop-foot during swing. The design incorporated two modes of operation: locked during swing for support and unlocked during stance for enhanced range of motion. Proof of concept testing with able-bodied subjects was conducted to test walking ability over level ground based on kinetic and kinematic parameters. The comparative tests confirmed the ability of the novel design to prevent drop-foot and its potential for enhanced ankle mobility during stance. Preliminary results indicate that the novel ankle joint should be refined to facilitate smooth and consistent unlocking but can be safely used in its current form with mobility impaired individuals.
Theoretical and Simulation Investigations on Flow Ripple Reduction of Axial Piston Pumps Using Nonuniform Distribution of Pistons
Authors: Lyu Fei , Ye Shaogan , Zhang Junhui , Xu Bing , Huang Weidi , Xu Haogong , Huang Xiaochen 
Published: October 2020

Abstract
The output flow ripple of the axial piston pump is one of the excitation sources for the hydraulic system vibration. The amplitudes of its specific harmonics must be reduced to avoid the resonance with the hydraulic pipeline. In this paper, a method on the nonuniform distribution of the pistons is put forward to adjust the flow ripple. The deflection angles of the pistons are used to describe the distribution rule. The distribution rule is imported to the Fourier expansion of the flow rate of each single-piston chamber, and then every single flow rate is superposed to obtain the Fourier coefficient of total flow rate that becomes the function of deflection angles. After this, objective optimization design is carried out to reduce the amplitudes of specific harmonics. Finally, the dynamic simulation model of the nonuniformly distributed axial piston pump is established to verify the effects of objective optimization. The results show that the amplitude of the ninth harmonic of the flow ripple can be reduced by about 40%, and the reductions are about 99% for the 18th and 27th harmonic.
Elastic Properties and Nonlinear Elasticity of the Noncarbon Hexagonal Lattice Nanomaterials Based on the Multiscale Modeling
Authors: Singh Sandeep , Ravi Raj B. M. , Mali Kiran D. , Watts Gaurav 
Published: October 2020

Abstract
This study presents the elastic properties and nonlinear elasticity of the two-dimensional noncarbon nanomaterials of hexagonal lattice structures having molecular structure XY. Four nitride-based and two phosphide-based two-dimensional nanomaterials, having graphene-like hexagonal lattice structure, are considered in the present study. The four empirical parameters associated with the attractive and repulsive terms of the Tersoff–Brenner potential are calibrated for noncarbon nanomaterials and tested for elastic properties, nonlinear constitutive behavior, bending modulus, bending and torsional energy. The mathematical identities for the tangent constitutive matrix in terms of the interatomic potential function are derived through an atomistic–continuum coupled multiscale framework of the extended version of Cauchy–Born rule. The results obtained using newly calibrated empirical parameters for cohesive energy, bond length, elastic properties, and bending rigidity are compared with those reported in the literature through experimental investigations and quantum mechanical calculations. The continuum approximation is attained through the finite element method. Multiscale evaluations for elastic properties and nonlinear stretching of the nanosheets under in-plane loads are also compared with those obtained from atomistic simulations.
Ultimate Limit State Equations and Plasticity of Tubular Conical Transitions
Authors: Ku Albert , Chen Jieyan 
Published: October 2020

AbstractConical transitions have wide applications in wind turbine foundation as well as oil and gas jacket type of structures. The junctions where tubular and cone meet experience a sharp stress rise from shell edge effects. Like all structures experiencing sharp stress rises, fatigue considerations are critical. In addition to fatigue, the existing offshore structural design standards also require ultimate limit state checks. It is known from the lower bound theorem of plasticity limit analysis that the junction local edge effects do not impact the global capacity. Designing for the local junction ultimate limit state contains wide variations among existing design standards. In this paper, the design practices from API RP-2A, NORSOK N-004, and ISO 19902:2020 draft are assessed. They are compared to the shell plastic yield criteria of Hodge and Ilyushin. In addition, this paper provides a semi-analytical plasticity solution to determine junction plastic deformations. The formulation is based on cylindrical shell equations coupled with deformation plasticity theory. It is found that the growth of the junction plasticity zone is limited, which is consistent with the anticipation from the lower bound limit analysis theorem. The observations made in this paper show that the local junction plasticity is a secondary issue compared to other design considerations. Its ultimate limit state design equation can afford to be more lenient if chooses for future standards’ development.
Structural Control of an Ultra-Large Semi-Submersible Floating Offshore Wind Turbine
Authors: Zhao Zhixin , Wang Wenhua , Han Dongdong , Shi Wei , Si Yulin , Li Xin 
Published: October 2020

Abstract
A braceless semi-submersible floating platform is proposed for a Technical University of Denmark (DTU) 10-MW wind turbine at moderate water depths with reference to an existing National Renewable Energy Laboratory (NREL) 5-MW braceless semi-submersible floating platform, and a servo control system for a 10-MW semi-submersible floating offshore wind turbine (FOWT) is introduced. To control the ultimate and fatigue loads of the FOWT, a fore-aft tuned mass damper (TMD) installed in the nacelle of the 10-MW semi-submersible FOWT was investigated for vibration alleviation and load reduction. Considering the hydrodynamic and mooring effect, a four degrees-of-freedom (DOFs) (platform surge and pitch motions, tower fore-aft bending, and TMD translation) simplified dynamic model for the 10-MW semi-submersible FOWT is established based on D’Alembert’s principle. Then, the parameter estimation is conducted based on the Levenberg–Marquardt (LM) algorithm, and the simplified dynamic model was further verified by comparing the output responses with FAST and the proposed model. Furthermore, the exhaustive search (ES) and genetic algorithm (GA) are embedded into the simplified dynamic model to optimize the TMD parameters. Finally, a fully coupled time-domain simulation for all the selected environmental conditions is conducted in FAST, and the vibration suppression performance of the optimized TMD design for the 10-W semi-submersible FOWT was further examined and analyzed.
Advanced NDIF Method for Eigenvalue Analysis of Arbitrarily Shaped Acoustic Cavities With the Partially Pressure-Release Boundary
Authors: Kang S. W. , Atluri Satya N. 
Published: October 2020

Abstract
In this paper, an advanced non-dimensional dynamic influence function method (NDIF method) for eigenvalue analysis of arbitrarily shaped two-dimensional acoustic cavities with the mixed boundary consisting of the pressure-release and rigid-wall boundaries is proposed. The existing NDIF method has the weakness of having to calculate the singularity of the final system matrix of an analyzed acoustic cavity in the frequency band of interest to obtain the eigenvalues of the cavity because the final system matrix is dependent on the frequency. The newly proposed NDIF method in this paper provides an efficient way to extract accurate eigenvalues and eigenmodes by successfully overcoming the above weaknesses. Finally, the validity and accuracy of the proposed method are shown through verification examples.
Global System Reduction Order Modeling for Localized Feature Inclusion
Authors: Quinn D. Dane , Brink Adam R. 
Published: October 2020

Abstract
The development of reduced-order models remains an active research area, despite advances in computational resources. The present work develops a novel order-reduction approach that is designed to incorporate isolated regions that contain, for example, nonlinearitites or accumulating damage. The approach is designed to use global modes of the overall system response, which are then naturally coupled to the response in the isolated region of interest. Two examples are provided to demonstrate both the accuracy and the computational efficiency of the proposed approach. The performance of this approach is compared to the exact response corresponding to a finite element simulation for the chosen problems. In addition, the accuracy and computational efficiency are shown relative to a standard Galerkin reduction based on the linear normal modes. It is found that the proposed reduction offer computational efficiency comparable to a Galerkin reduction, but more accurately represents the response of the system when both are compared to the finite element simulation.
Benefits of medication charts provided at transitions of care: a narrative systematic review
Authors: Dietrich Fine Michèle , Hersberger Kurt E , Arnet Isabelle 
Published: October 2020

ObjectivesParticularly at transitions of care points information concerning current medication tends to be incomplete. A medication chart that contains all essential information on current therapy is likely to be a helpful tool for patients and healthcare providers. We aimed to investigate any type of benefits associated with medication charts provided at transition points.MethodsA systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed. Two databases, two online journals and two association websites dedicated to biomedicine and pharmacy issues were consulted to identify studies for the review using the search term ‘medication chart’ and synonyms. We run our search from database inception up to March 2019. Studies of any study design, intervention and population which examined the effect of paper-based medication charts were included. We extracted study results narratively and coded and classified them by themes and categories inductively by using the ‘framework method’ with content analysis. The methodological quality of the studies was assessed using the Effective Public Health Practice Project (EPHPP) tool.ResultsFrom the 846 retrieved articles, 30 studies met the inclusion criteria, mostly from Germany (18 studies) and the USA (5 studies). Thirteen studies reported a statistically significant result. In the ‘patient theme’, the most obvious benefits were an increase in medication knowledge, a reduction of medication errors and higher medication adherence. In the ‘interdisciplinary theme’, a medication chart represented a helpful tool to increase communication and inter-sectoral cooperation between healthcare providers. In the ‘theme of terms and conditions’, accuracy and currency of data are prerequisites for any positive effect. The quality of the studies was classified predominantly weak mainly due to unmet good quality criteria (no randomised controlled trials study design, no reported dropouts).ConclusionOverall, the reviewed studies suggested some benefits when using medication charts. Healthcare providers could consider using medication charts in their counselling practice. However, it is unknown whether the reported benefits lead to measurable improvement in clinical outcomes.PROSPERO registration number
The role of concomitant ligament injury in the development of post-traumatic osteoarthritis after distal radius fractures: a protocol for a systematic review
Authors: Slichter Malou E , Kraan Gerald A , Bramer Wichor M , Colaris Joost W , Mathijssen Nina M C 
Published: October 2020

IntroductionTreatment of distal radius fractures (DRFs) aims to restore anatomic position of the fracture fragments and congruity of the articular surface to optimise functional outcomes and prevent osteoarthritis in the long term. While ligament injury of the wrist is often associated with DRFs and sole ligament injuries of the wrist lead to osteoarthritis, it is plausible that concomitant ligament injury in DRFs may aggravate degenerative changes of the wrist. The relationship between concomitant ligament injury and post-traumatic osteoarthritis in patients with DRFs is unclear. This study aims to identify the types of associated ligament injury in patients with a DRF and to elucidate the association of ligament injury on the development of post-traumatic osteoarthritis.Methods and analysisThis protocol is written in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol (PRISMA-P) guidelines. An electronic search in MEDLINE, Embase, Web of Science, Cochrane Central Register of Trials and Google Scholar has been created and performed by a Health Sciences librarian with expertise in systematic review searching. Original research articles in English literature, which report on concomitant ligament injury of the wrist in relation to post-traumatic osteoarthritis, patient-reported outcome measures or clinician-reported outcome measures in patients (aged ≥18 years) with DRFs will be included. Two reviewers will independently screen and appraise articles and perform data extraction. In case of any disagreements, a third reviewer will be consulted. A systematic qualitative synthesis will be performed using text and tables.Ethics and disseminationNo ethical approval is required, since this is a protocol for a systematic review. The systematic review will be submitted for publication in a peer-reviewed scientific journal and for presentation at relevant conferences.PROSPERO registration numberCRD42020165007.