bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker
Authors: Li Tian , Sun Xiangzhou , Chen Liheng 
Published: October 2019

AbstractCircular RNAs (circRNAs) are important regulators in cancer growth and progression. Exosomes carry various molecules including RNA, protein, and lipid from one cell to another cell. But the role of circRNAs from the exosomes from prostate cancer patients are not elucidated. In this study, circ_0044516 was found upregulated in prostate cancer and the roles and molecular mechanism of Hsa_circ_0044516 (circ_0044516) was investigated. Firstly, the exosomes of prostate cancer patients were collected for human circRNAs microarray to screen the circRNA expression profile. There were 35 significantly expressed circRNAs with more than fivefolds from microarray analysis. Circ_0044516 was verified to be significantly upregulated in the exosomes from prostate cancer patients and the cell lines. Further investigation demonstrated that circ_0044516 downregulation inhibited the proliferation and metastasis of prostate cancer cells. By bioinformatics and luciferase reporter assays, circ_0044516 was verified to downregulate miR‐29a‐3p expression and negatively related to miR‐29a‐3p expression levels in prostate cancer. In a summary, the study indicated that circ_0044516 played an important role in prostate cancer cell survival and metastasis, which suggested that an oncogenic role of circ_0044516 in prostate cancer.
Identification SYT13 as a novel biomarker in lung adenocarcinoma
Authors: Zhang Liyan , Fan Bijun , Zheng Yu , Lou Yueyan , Cui Yongqi , Wang Ke , Zhang Tiancheng , Tan Xiaoming 
Published: October 2019

AbstractSynaptotagmins are a class of proteins that play an important role in the secretion of neurotransmitters by synaptic vesicles. However, recent studies have shown that members of this family also have a certain function in the development of tumors. In this study, we first identified through The Cancer Genome Atlas data analyzed that a novel synaptotagmin, SYT13, was closely related to the prognosis of lung adenocarcinoma, but was not significantly correlated with the prognosis of lung squamous cell carcinoma. Then we knocked down the expression of SYT13 gene in lung adenocarcinoma cell lines A549 and H1299, and successfully induced decreased proliferation and clonality of lung adenocarcinoma cell lines, and observed cell cycle arrest and apoptosis enhancement in both cell lines. In addition, we detected the migration ability of SYT13 knockdown lung adenocarcinoma cell lines by the cell scratch test and the transwell test. Interestingly, there was a decreased migration ability of SYT13 knockdown in H1299 cells even though there was no significant difference in the migration of A549 cells. These results demonstrate that SYT13 plays an important role in the development of lung adenocarcinoma, which deepens our understanding of the mechanism of lung adenocarcinoma development and provides new possibilities for targeted therapy of lung adenocarcinoma.
Gender minority stress, sleep disturbance, and sexual victimization in transgender and gender nonconforming adults
Authors: Kolp Haley , Wilder Shannon , Andersen Catherine , Johnson Ellen , Horvath Sarah , Gidycz Christine A. , Shorey Ryan 
Published: October 2019

AbstractObjectiveThe current study examined facets of gender minority stress (nonaffirmation, internalized transphobia) and protective factors (community connectedness, transgender identity pride) as potential moderators of the relationship between sexual victimization and sleep disturbances among transgender and gender nonconforming (TGNC) adults.MethodsTGNC adults (n = 191) were recruited through Amazon's Mechanical Turk. The average age was 30.28 years old (SD = 7.09; range 18–71) and the majority (55%) identified in the transfemale spectrum.ResultsResults demonstrated a significant two‐way interaction between sexual victimization and internalized transphobia, such that sexual victimization was more strongly related to sleep disturbances when internalized transphobia was low (β = .14, p = .017) relative to high (β = −0.09, p = .221).ConclusionsThis study is the first to establish the relationship between sexual victimization and sleep disturbances in TGNC individuals. Additional research is needed to replicate these findings longitudinally.
c‐Myc controls the fate of neural progenitor cells during cerebral cortex development
Authors: Wang Xiu‐Li , Ma Yan‐Xia , Xu Ren‐Jie , Ma Jin‐Jin , Zhang Hong‐Cheng , Qi Shi‐Bin , Xu Jin‐Hui , Qin Xu‐Zhen , Zhang Hao‐Nan , Liu Chang‐Mei , Chen Jian‐Quan , Li Bin , Yang Hui‐Lin , Saijilafu  
Published: October 2019

AbstractThe anatomical structure of the mammalian cerebral cortex is the essential foundation for its complex neural activity. This structure is developed by proliferation, differentiation, and migration of neural progenitor cells (NPCs), the fate of which is spatially and temporally regulated by the proper gene. This study was used in utero electroporation and found that the well‐known oncogene c‐Myc mainly promoted NPCs’ proliferation and their transformation into intermediate precursor cells. Furthermore, the obtained results also showed that c‐Myc blocked the differentiation of NPCs to postmitotic neurons, and the expression of telomere reverse transcriptase was controlled by c‐Myc in the neocortex. These findings indicated c‐Myc as a key regulator of the fate of NPCs during the development of the cerebral cortex.
Haspin inhibition delays cell cycle progression through interphase in cancer cells
Authors: Wang Peiling , Hua Xiangmei , Bryner Yuge Han , Liu Sijing , Gitter Christopher B. , Dai Jun 
Published: October 2019

AbstractHaspin (Haploid Germ Cell‐Specific Nuclear Protein Kinase) is a serine/threonine kinase pertinent to normal mitosis progression and mitotic phosphorylation of histone H3 at threonine 3 in mammalian cells. Different classes of small molecule inhibitors of haspin have been developed and utilized to investigate its mitotic functions. We report herein that applying haspin inhibitor CHR‐6494 or 5‐ITu at the G1/S boundary could delay mitotic entry in synchronized HeLa and U2OS cells, respectively, following an extended G2 or the S phase. Moreover, late application of haspin inhibitors at S/G2 boundary is sufficient to delay mitotic onset in both cell lines, thereby, indicating a direct effect of haspin on G2/M transition. A prolonged interphase duration is also observed with knockdown of haspin expression in synchronized and asynchronous cells. These results suggest that haspin can regulate cell cycle progression at multiple stages at both interphase and mitosis.
Obituary: Tomonari Kaji (1982–2019), evolutionary morphologist extraordinaire
Authors: Palmer A. Richard 
Published: October 2019

AbstractDr. Tomonari Kaji, an exceptional young evolutionary morphologist at the University of Alberta, passed away unexpectedly in May of this year. His passion for the study of developmental and evolutionary transformations yielded a succession of intriguing papers about how spectacular morphological innovations develop or evolved, including such remarkable structures as crustacean suction cups, squirting heads in termite soldiers, envenomating mandibles in copepods, and shrimp and amphipod claws that create explosive snaps. Significantly, his work is a valuable reminder of how great advances in our understanding of the development and evolution of morphological innovations can be made simply by looking carefully and thinking about what you see, no genetics/genomics or complex statistics required. Long live comparative morphology.
Normal edge‐colorings of cubic graphs
Authors: Mazzuoccolo Giuseppe , Mkrtchyan Vahan 
Published: October 2019

AbstractA normal ‐edge‐coloring of a cubic graph is a proper edge‐coloring with colors having the additional property that when looking at the set of colors assigned to any edge and the four edges adjacent to it, we have either exactly five distinct colors or exactly three distinct colors. We denote by the smallest , for which admits a normal ‐edge‐coloring. Normal ‐edge‐colorings were introduced by Jaeger to study his well‐known Petersen Coloring Conjecture. More precisely, it is known that proving for every bridgeless cubic graph is equivalent to proving the Petersen Coloring Conjecture and then it implies, among others, Cycle Double Cover Conjecture and Berge‐Fulkerson Conjecture. Considering the larger class of all simple cubic graphs (not necessarily bridgeless), some interesting questions naturally arise. For instance, there exist simple cubic graphs, not bridgeless, with . In contrast, the known best general upper bound for was . Here, we improve it by proving that for any simple cubic graph , which is best possible. We obtain this result by proving the existence of specific nowhere zero ‐flows in ‐edge‐connected graphs.
Inappropriate sinus tachycardia or…something else?
Authors: Muresan Lucian , Le Bouar Ronan , Greciano Stephane , Muresan Crina , Schiau Serban , Cismaru Gabriel , Levy Jacques 
Published: October 2019

AbstractWe report the case of a 45‐year old female patient with a past medical history of rheumatoid arthritis who presented to our cardiology department with a suspicion of inappropriate sinus tachycardia. Echocardiography showed a nondilated left ventricle with a preserved ejection fraction. A careful reinterpretation of her 12‐lead ECG reoriented the diagnosis toward an incessant atrial tachycardia. The diagnosis was confirmed by an electrophysiologic study performed with an electro‐anatomic mapping system, which identified the origin of the tachycardia at the level of the right atrial appendage. Radiofrequency ablation of the ectopic focus eliminated the tachycardia and improved the patient's symptoms.
The effect of firm size, asset ownership, and market prices on regulatory violations
Authors: Scott Alex , Nyaga Gilbert N. 
Published: October 2019

AbstractAn individual's temptation to violate regulations for personal gain increases with the economic payoff to do so. Firms, however, adopt strategies to reduce undesirable behavior from their employees. This article examines how individuals change their propensity to violate regulations as the price for their services varies. We posit that individuals will commit more intentional, but not unintentional, violations as the payoff to do so increases, and that this effect will be moderated by the size of the firm for whom he or she works and whether the firm or the individual owns the assets used for production. To test our hypotheses, we link data from millions of inspections of truck driver logbooks with spot market prices observed over the same 4‐year period. We find that drivers who operate independently intentionally violate restrictions on their work hours more frequently when prices increase—violating 34% more frequently when prices are at their highest versus lowest—but larger firms and the firm's ownership of the assets reduce a driver's responsiveness to price changes. At the extreme, drivers for large asset‐owning firms are completely unresponsive to prices. Asset‐owning drivers are responsive to market prices, even for the largest firms.
Intervention as a research strategy
Authors: Oliva Rogelio 
Published: October 2019

AbstractThe Journal of Operations Management (JOM) has made design science central to its development strategy, creating a department to incubate papers using this methodology. An inaugural editorial published in 2016 called for papers with a generic design supported by adesign propositionthat provides pragmatic guidelines to bridge the gap between the case specific and the universal. In this article, I propose ways in which the scope of interventions can be expanded beyond the editorial's proposal to foster theoretical developments and better align with JOM's mission. I propose that, rather than focus on the design propositions, we explore the role that interventions (the ultimate manifestation of design science) can play in testing and developing theory (the ultimate goal of an academic endeavor). Taking as a point of departure the principles ofaction researchand the explanatory framework ofprocess theories, I propose two modes of research for leveraging interventions as a mechanism for testing existing theory and develop theories about organizational and system transformation. I illustrate the application of these two frameworks in the context of a previously published article.
Site formation processes at Donggutuo: a major Early Pleistocene site in the Nihewan Basin, North China
Authors: Jia Zhenxiu , Pei Shuwen , Benito‐Calvo Alfonso , Ma Dongdong , Sanchez‐Romero Laura , Wei Qi 
Published: October 2019

ABSTRACTUnderstanding site formation processes is crucial for interpreting archaeological context patterns and hominin behaviour as these affect the preserved condition of a site and the integrity of archaeological remains. The fluvio‐lacustrine sequences in the Nihewan Basin of North China are rich sources of early Pleistocene archaeological sites, which offer an important opportunity to investigate human evolution and adapted behaviours in East Asia. Although many Palaeolithic sites have been reported from the Nihewan Basin, North China, few of them focus on site formation processes before interpreting the hominin behaviour patterns. Here, we present a site formation study of four archaeological layers (Layers 6D, 6C, 6B and 6A) in Trench 1 from the Donggutuo (namely DGT‐T1) site in the Nihewan Basin with an age of 1.1 Ma. Through the study of sedimentary contexts, spatial distributions of artefacts and fossils, intra‐assemblage category ratios, debitage size distributions, lithic abrasion, artifact orientation and planar dip, our results show that all the layers had been disturbed by low‐energy sheet wash across the lake shore setting, but to differing extents. The post‐depositional disturbance caused by water decreased from the lower to the upper layers, from Layer 6D to Layer 6A. This indicates that the archaeological remains in DGT‐T1 have not been subject to significant natural modifications and are thus suitable for studying early hominin behaviour in North China. Copyright © 2019 John Wiley & Sons, Ltd.
Non‐invasive on‐site Raman study of polychrome and white enamelled glass artefacts in imitation of porcelain assigned to Bernard Perrot and his followers
Authors: Colomban Philippe , Kırmızı Burcu 
Published: October 2019

AbstractBernard Perrot produced sophisticated glass objects from ~1666–1709 in Orléans, particularly white enamelled artefacts and ruby glass. We present here the first non‐invasive Raman study of 16 polychrome and white enamelled glass artefacts that are assigned to Bernard Perrot or his followers. These glasses belong to the museum collections at Orléans and Sèvres in France. The prominent characteristic of these artefacts is their white bodies that were produced in imitation of porcelain. The small thickness of enamel applied to these glasses imposes the use of a high magnification (×200) long working distance microscope objective for Raman analysis. Pigments and opacifiers were identified, and the production technology was discussed. White opacification was found to be obtained by three compounds: calcium phosphate (bone opacification) for blown utensils, calcium antimonate for figurines, and cassiterite for thin enamels. The use of characteristic arsenic‐rich European cobalt was identified in the blue enamels with the characteristic Raman signature of lead arsenate apatite as observed for the 17th and 18th century French soft‐paste porcelains and Limoges enamels. The easy Raman detection of arsenic‐rich phases also allows on‐site identification of ruby glasses produced according to Perrot's technique (formation of Au° colloids by reaction initiated with an arsenic salt). The amount and crystallinity of calcium phosphate being variable appears to be a potential tool to discriminate between different production periods or workshops.
Annual Winter Site Fidelity of Barrow's Goldeneyes in the Pacific
Authors: Willie Megan , Esler Daniel , Boyd W. Sean , Bowman Timothy , Schamber Jason , Thompson Jonathan 
Published: October 2019

ABSTRACTCoastal regions on the Pacific north coast of North America provide important wintering habitat for many species of sea ducks. Although winter range and habitat preferences are well described for most species, fidelity to coastal wintering sites is generally undocumented. Fidelity is an important factor necessary for understanding interactions with coastal developments and activities and corresponding management strategies. We used data from Barrow's goldeneyes (Bucephala islandica), a sea duck that winters predominantly in nearshore habitats along the Pacific north coast, to investigate inter‐annual fidelity to, and intra‐annual fidelity within, coastal wintering sites. Between 2006 and 2015, we marked goldeneyes on breeding, molting, and wintering sites with satellite transmitters. We retained 4,931 locations in coastal habitats from 221 goldeneyes across 4 coastal regions for our analyses. These birds demonstrated high inter‐annual fidelity to coastal wintering sites; 75% of selected wintering sites were within 29 km of sites used the previous winter. Inter‐annual fidelity to wintering sites was similar between sex and age classes but differed by coastal region. Goldeneyes from southcentral Alaska, USA, expressed greater inter‐annual fidelity relative to birds from northern or southern British Columbia, Canada, and southeast Alaska. Goldeneyes also expressed high intra‐annual fidelity within wintering sites, with 75% of individuals averaging within‐season movements of ≤9 km. Intra‐annual fidelity was lesser for female than male goldeneyes but did not differ between hatch‐year and after‐hatch‐year birds. We found regional variation in intra‐annual fidelity, with goldeneyes from southcentral Alaska expressing greater intra‐annual fidelity compared to birds from other regions. High inter‐ and intra‐annual winter site fidelity by Barrow's goldeneyes suggests that, at a population level, habitat use is predictable and can be used to inform risk assessment or to evaluate factors affecting habitat choice. Also, low dispersal among wintering sites suggests that recovery from population perturbations, whether caused by natural or anthropogenic events, will be protracted. © 2019 The Wildlife Society.
Antecedents and outcomes of digital influencer endorsement: An exploratory study
Authors: Torres Pedro , Augusto Mário , Matos Marta 
Published: October 2019

AbstractThe advertising and marketing literature have established that celebrity endorsements constitute an effective way to enhance attitudes toward brands and increase purchase intents. However, there are no relevant studies on digital influencers. This study addresses the research gap by examining the effect of digital influencers' attractiveness and the effect of the congruence between a digital influencer and a brand on consumer attitudes and purchase intentions. By applying structural equation modeling to a sample of 307 followers of digital influencers, a model was tested and group analysis was performed for two categories (“entertainment & video games” and “fashion & beauty”). The results show that both brand attitudes and purchase intentions are influenced by the digital influencer's attractiveness (which includes both likeability and familiarity) and by the congruence between the digital influencer and the brand. This study makes several contributions to both theory and practice, which are highlighted in this paper.
Repair of the femoral nerve by two motor branches of the obturator nerve: A case report
Authors: Dubois Elodie , Popescu Ion‐Andrei , Sturbois Nachef Nadine , Teboul Frederic , Goubier Jean‐Noel 
Published: October 2019

AbstractComplete femoral nerve palsies are uncommon but devastating injuries when they are caused by large nerve defects. Direct repair is usually not possible and nerve grafting renders uncertain outcomes. Recent studies proposed different peripheral nerve transfers as treatment strategies for large femoral nerve defects. We report a clinical application of a nerve transfer to reinnervate the quadriceps muscle with two motor branches of the obturator nerve in a 48 years‐old man that was diagnosed with a femoral nerve palsy after resection of a retroperitoneal schwannoma. The branches supplying the gracilis and adductor longus muscles were transferred to the motor branch of the femoral nerve to the quadriceps muscle at 6 months postinjury. At 34 months of follow‐up, knee extension was quoted M4. The presented nerve transfer may be feasible, technically simple, and renders good functional outcomes.
Extremely miniaturized dual‐mode defected ground structure duplexer based on fractal structure
Authors: Song Kaijun , Luo Mou , Zhong Cuilin , Patience Shema R. 
Published: October 2019

AbstractA novel extremely miniaturized dual‐mode defected ground structure (DGS) duplexer based on fractal structure is presented. To further reduce the circuit size, the novel DGS resonator with Hilbert fractal structure is used. The equivalent circuits of the presented duplexer are given to analyze and design the duplexer. An extremely miniaturized dual‐mode DGS‐resonator duplexer with the center frequencies of 1.9 GHz and 2.14 GHz, respectively is designed and assembled. The total size of the assembled duplexer is only 0.23λg × 0.1λg. The measured results are in good agreement with the simulated results.
Accelerated mono‐ and biexponential 3D‐T1ρ relaxation mapping of knee cartilage using golden angle radial acquisitions and compressed sensing
Authors: Zibetti Marcelo V. W. , Sharafi Azadeh , Otazo Ricardo , Regatte Ravinder R. 
Published: October 2019

PurposeTo use golden‐angle radial sampling and compressed sensing (CS) for accelerating mono‐ and biexponential 3D spin‐lattice relaxation time in the rotating frame (T1ρ) mapping of knee cartilage.MethodsGolden‐angle radial stack‐of‐stars and Cartesian 3D‐T1ρ‐weighted knee cartilage datasets (n= 12) were retrospectively undersampled by acceleration factors (AFs) 2‐10. CS‐based reconstruction using 8 different sparsifying transforms were compared for mono‐ and biexponential T1ρ‐mapping of knee cartilage, including spatio‐temporal finite differences, wavelets, dictionary from principal component analysis, and exponential decay models, and also low rank and low rank plus sparse models (L+S). Complex‐valued fitting was used and Marchenko‐Pastur principal component analysis filtering also tested.ResultsMost CS methods performed well for an AF of 2, with relative median normalized absolute deviation below 10% for monoexponential and biexponential mapping. For monoexponential mapping, radial sampling obtained a median normalized absolute deviation below 10% up to AF of 10, while Cartesian obtained this level of error only up to AF of 4. Radial sampling was also better with biexponential T1ρmapping, with median normalized absolute deviation below 10% up to AF of 6.ConclusionGolden‐angle radial acquisitions combined with CS outperformed Cartesian acquisitions for 3D‐T1ρmapping of knee cartilage, being it is a good alternative to Cartesian sampling for reducing scan time and/or improving image and mapping quality. The methods exponential decay models, spatio‐temporal finite differences, and low rank obtained the best results for radial sampling patterns.