bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbonate-shelf evolution during the Oligocene to early Miocene: insights from shelf architecture, lithofacies, and depositional models of the Kujung Formation, offshore East Java, Indonesia
Authors: Fifariz Reynaldy , Janson Xavier , Kerans Charles , Sapiie Benyamin 
Published: August 2020

ABSTRACTOligocene–Miocene carbonates are prolific hydrocarbon reservoirs in Southeast Asia. Extensive subsurface data for this stratigraphic section has become available through exploration and production activities. A carbonate shelf in the study area showed an evolution in shelf architecture and lithofacies during this period. Despite the economic importance, complexity, and data availability, there have been few published studies on a comprehensive description and interpretation of carbonate-shelf evolution in the region.We utilized data from nineteen wells and 1,300 km2 of 3D seismic data from offshore East Java to study the Oligocene–Miocene Kujung Formation. An average of 700 m stratigraphic sections from this formation were analyzed. This interval spans 13.5 million years (My) from the Rupelian, Chattian, through Aquitanian constrained by numerical ages from 87Sr/86Sr. The Kujung Formation is subdivided into the Rupelian–Chattian mixed-siliciclastic–carbonate shelf (MSCS) and the Aquitanian carbonate-buildups shelf (CBS) based on shelf architecture and lithofacies. The boundary between the MSCS and CBS is interpreted to be near the Oligocene–Miocene boundary at 23 Ma. Accumulation rates in the CBS are up to three times greater than that of the MSCS. We propose new depositional models for the Kujung Formation, which was used to discuss the dominant controls on shelf evolution.This study suggests that although climate played a role in dictating environmental conditions during the Oligocene–Miocene, the dominant factors controlling carbonate-shelf evolution in the study area appear to have been antecedent topography, routing of siliciclastic sediment, and patterns of sea-level fluctuation.
TB or not TB: banding in turbidite sandstones
Authors: Stevenson Christopher J. , Peakall Jeff , Hodgson David M. , Bell Daniel , Privat Aurélia 
Published: August 2020

ABSTRACT
Recognition and interpretation of sedimentary structures is fundamental to understanding sedimentary processes. Banded sandstones are an enigmatic sedimentary facies comprising alternating mud-rich (as matrix and/or mud clasts) and cleaner sand layers. The juxtaposition of hydrodynamically different grain sizes contradicts established models of cleaner-sand bedform development. Here, outcrop, subsurface core, and petrographic data from three deep-water systems, with well-constrained paleogeographic contexts, are used to describe the range of sedimentary textures, bedform morphologies, and facies associations, and to quantify the mud content of banding. Banding can occur in any part of a bed (base, middle, or top), but it typically overlies a structureless basal sandstone or mud-clast conglomerate lag, and is overlain by clean parallel-laminated sandstone and/or ripple cross-lamination. Banding morphology ranges from sub-parallel to bedforms that comprise low-angle laminae with discontinuous lenses of mudstone, or asymmetric bedforms comprising steeply dipping foresets that transition downstream into low-amplitude bedwaves, or steeply dipping ripple-like bedforms with heterolithic foresets. This style of banding is interpreted as a range of bedforms that form progressively in the upper-stage plane-bed flow regime via tractional reworking beneath mud-laden transitional plug flows. The balance of cohesive and turbulent forces, and the rate of flow deceleration (aggradation rate), govern the style of deposit. Banded sandstones and linked debrites are rarely found juxtaposed together in the same bed because they are distributed preferentially in proximal and distal settings, respectively. Understanding the origins of banding in turbidite sandstones, the conditions under which it forms, and its distribution across deep-water systems and relationship to linked debrites, is important for it to be used effectively as a tool to interpret the geological record.
Diagnosing Multistage Fracture Treatments with Distributed Fiber-Optic Sensors
Authors: Pakhotina Iuliia , Sakaida Shohei , Zhu Ding , Hill A. Daniel 
Published: August 2020

Summary
Distributed acoustic-sensing technology is a diagnostic method that has been implemented in the oil and gas industry for flow monitoring during injection or production. One of the applications is to estimate fluid distribution during hydraulic fracturing treatment. This is an invaluable diagnostic tool for multistage fracture treatments because of the large number of parameters and high uncertainty involved in these fracture treatments. Distributed acoustic sensor (DAS) measurements are based on data extracted from a fiber-optic cable installed in a wellbore. Fiber-optic cable strain is sensitive to temperature and acoustic variations induced by fluid flow with different fluid properties and fracture geometries. These parameters are evaluated from the backscattered laser pulse through the fiber using coherent Rayleigh backscattering for DAS and Raman backscattering for distributed temperature sensing (DTS). The DAS interrogation system acquires strain response to acoustic variations along the measured depth of the wellbore for all periods of time.
This study presents a method of interpretation of flow-rate distribution from acoustic signals from DAS measurements. Raw acoustic measurements are transformed into energy-attribute distribution for all necessary depth locations and time frame. It allows calculating energy for each perforation cluster location. This calculation demands proper depth-interval consideration for each perforation cluster. A depth-windowing procedure allowing location of intervals where DAS channel measurements must be integrated for each timestep is applied to all stages. Based on previous experimental and computational fluid-dynamic investigations, the correlation between acoustic signal and flow rate is applied to interpret the measured DAS data to flow distribution.
In this paper, the system of equations that connects acoustic energy response with clusters flow-rate distribution during the injection period using these correlations is introduced. The solution of this system allows calculating cumulative volume for each perforation cluster on each timestep and at the end of fracture treatment. As additional verification of flow-rate distribution, the results of DAS interpretation were compared with the interpretation results of DTS. A field example is used to illustrate the interpretation procedure.
From this work, it is concluded that, besides qualitative analysis, the DAS interpretation method provides a quantitative estimation of flow distribution. Based on current assumptions, the interpretation results from DAS and DTS are comparable with a satisfactory agreement. The combined DAS and DTS interpretations help in understanding cluster efficiency in multistage fracture treatments.
Motivations, experiences and aspirations of Trainee Nursing Associates in England. A qualitative study
Authors: King Rachel Louise , Ryan Tony , Wood Emily , Tod Angela , Robertson Steve 
Published: August 2020

Abstract
BackgroundThe nursing associate role was developed in England in response to the ‘Shape of Caring’ review. It has been implemented to fulfil two aims; to bridge the gap between registered nurses and healthcare assistants, and to provide an alternative route into registered nursing in light of workforce shortages.Other high income countries deploy second level nurses within their healthcare systems, however the UK has a turbulent history with such roles. The previous state enrolled nurse was phased out in the 1990s, and more recently the assistant practitioner (AP) role has faced wide variation in titles, scope and pay. Little is known about those who have embarked on the new nursing associate training course and their experiences of the role.MethodsAn exploratory qualitative study was undertaken using focus groups of trainee nursing associates to generate in-depth discussion about their motivations, experiences of training, and career aspirations.Three focus groups (n=15) took place in December 2018 using a purposive sample of trainee nursing associates registered at a University in the North of England. Two researchers facilitated each group discussion at a time and place convenient for participants. The discussions were audio recorded, transcribed and data was analysed thematically.ResultsThis study found that trainee nursing associates are motivated by affordable, local, career development. During training they face challenges relating to clinical support, academic workload and uncertainty about future career opportunities. They experience role ambiguity both individually and across the wider organisation. Trainee nursing associates rely on broad support networks to build their occupational identity.ConclusionsThe barriers and facilitators of trainee nursing associate personal development have implications for policy and practice relating to recruitment and retention. The results increase our understanding of this emerging role, and have informed the development of a larger longitudinal cohort study. Further research is required to evaluate the impact of this new role.
Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA
Authors: Liu Juejun , Chen Changzheng , Li Lu , Xu Yishuang , Yi Zuohuizi , He Lu , Zheng Hongmei 
Published: August 2020

Abstract
Background: To quantify blood flow changes in choriocapillaris (CC) of chronic central serous chorioretinopathy (CCSC) patients receiving half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA).Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA.Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up when compared with that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.
Young Medical Doctors’ Perspectives on Professionalism: A Qualitative Study Conducted in Public Hospitals in Pakistan
Authors: Jalil Aisha , Mahmood Qaisar Khalid , Fischer Florian 
Published: August 2020

Abstract
Background: Professionalism is amongst the major dimensions determining the competence of medical doctors. Poor professionalism affects the overall outcome of healthcare services. This study explores the perspectives of young medical doctors on professionalism in Pakistan.Methods: A qualitative study based on in-depth interviews was conducted with 60 young medical doctors, aged less than 40 years, who had studied medicine in Pakistani universities, were Pakistani nationals, and were employed at various hierarchical levels, from house officer to consultant specialist, in public tertiary hospitals in Pakistan. The respondents were identified through a multistage maximum heterogeneity sampling strategy. A semi-structured interview guide was developed based on a previous extensive literature review. Written consent was obtained from the hospitals and study participants. Qualitative thematic analysis was applied to analyse the data.Results: The data analysis revealed that rigidity of opinions, unacceptability of contrasting perspectives, false pride, and perceived superiority over other professions and patients were major components of poor medical professionalism. Most of the young doctors believed that there is no need to include professionalism and humanity course modules in the medical curriculum, because topics related to social sciences are deemed irrelevant to medicine and judged to be common sense. The doctors recognised good professionalism in themselves, while reporting unprofessional behaviour demonstrated by their colleagues and paramedics. Other factors contributing to poor medical professionalism included the use of social media applications during duty hours, ridiculing patients, substance use such as smoking cigarettes in the office, referrals of complicated cases to other hospitals, freeing up beds before holidays, lack of cooperation from paramedical staff, and inadequate role models.Conclusions: Poor medical professionalism among young doctors needs to be addressed by policymakers. There is a need to revisit the medical curriculum to strengthen professionalism. It is essential to develop the qualities of tolerance, teachability, and acceptance in doctors in order to facilitate interprofessional collaborations and avoid medical errors.
Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Authors: Dorji Jigme , Jagt Christy J. Vander , Garner Josie B. , Marett Leah C. , Mason Brett , Reich Coralie M. , Xiang Ruidong , Clark Emily L. , Cocks Benjamin G. , Chamberlain Amanda J. , MacLeod Iona M. , Daetwyler Hans D. 
Published: August 2020

Abstract
Background Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterized by impaired cellular energy metabolism. Cellular energy metabolism in mitochondria involves mitochondrial proteins (MP) from both the nuclear (NuMP) and mitochondrial (MtMP) genomes. The expression of MP genes in tissues may be tissue specific to meet varying specific energy demands across the tissues. Currently, the characteristics of MP gene expression in tissues of dairy cattle are not well understood. In this study, we profile the expression of MP genes in 29 adult and six foetal tissues in dairy cattle using RNA sequencing and gene expression analyses: particularly differential gene expression and co-expression network analyses.Results MP genes were differentially expressed (DE; over-expressed or under-expressed) across tissues in cattle. All 29 tissues showed DE NuMP genes in varying proportions of over-expression and under-expression. On the other hand, DE of MtMP genes was observed in <50% of tissues and notably MtMP genes within a tissue was either all over-expressed or all under-expressed. A high proportion of NuMP (up to 60%) and MtMP ( up to 100%) genes were over-expressed in tissues with expected high metabolic demand; heart, skeletal muscles and tongue, and under-expressed (up to 45% of NuMP, 77% of MtMP genes) in tissues with expected low metabolic rates; leukocytes, thymus, and lymph nodes. These tissues also invariably had the expression of all MtMP genes in the direction of dominant NuMP genes expression. The NuMP and MtMP genes were highly co-expressed across tissues and co-expression of genes in a cluster were non-random and functionally enriched for energy generation pathway. The differential gene expression and co-expression patterns were validated in independent cow and sheep datasets.Conclusions The results of this study support the concept that there are biological interaction of MP genes from the mitochondrial and nuclear genomes given their over-expression in tissues with high energy demand and co-expression in tissues. This highlights the importance of considering MP genes from both genomes in future studies related to mitochondrial functions and traits related to energy metabolism.
Downregulation of Long Noncoding RNA TUG1 Attenuate MTDH /NF-κB/IL-1β mediated inflammatory damage via Targeting miR-29b-1-5p After Spinal cord ischemia reperfusion in rats
Authors: Jia Hui , Li Zhe , Fang Bo , Chang Yi , Zhou Yongjian , Ma Hong 
Published: August 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Racial disparities in pedestrian-related injury hospitalizations in the United States
Authors: Hamann Cara , Peek-Asa Corinne , Butcher Brandon 
Published: August 2020

Abstract
Background. Racial/ethnic disparity has been documented in a wide variety of health outcomes, and environmental components are contributors. For example, food deserts have been tied to obesity rates. Pedestrian injuries are strongly tied to environmental factors, yet no studies have examined racial disparity in pedestrian injury rates. We examine a nationally-representative sample of pedestrian-related hospitalizations in the United States to identify differences in incidence, severity, and cost by race/ethnicity.Methods. Patients with ICD diagnosis E-codes for pedestrian injuries were drawn from the United States Nationwide Inpatient Sample (2009-2016). Rates were calculated using the United States Census. Descriptive statistics and generalized linear regression were used to examine characteristics (age, sex, severity of illness, mortality rates, hospital admissions, length of stay, total costs) associated with hospitalizations for pedestrian injuries.Results. The annual average of pedestrian-related deaths exceeded 5,000 per year and hospitalizations exceeded 47,000 admissions per year. The burden of injury from pedestrian-related hospitalizations was higher among Black, Hispanic, and Multiracial/Other groups in terms of admission rates, costs per capita, proportion of children injured, and length of stay compared to Whites and Asian or Pacific Islander race/ethnicities. Compared to Whites, hospital admission rates were 1.92 (95% CI: 1.89-1.94) and 1.20 (95% CI: 1.19-1.21) times higher for Multiracial/Other and Blacks, respectively. Costs per capita ($USD) were $6.30, $4.14, and $3.22 for Multiracial/Others, Blacks, and Hispanics, compared to $2.88 and $2.32 for Whites and Asian or Pacific Islanders. Proportion of lengths of stay exceeding one week were larger for Blacks (26.4%), Hispanics (22.6%), Asian or Pacific Islanders (23.1%), and Multiracial/Other (24.1%), compared to Whites (18.6%). Extreme and major loss of function proportions were also highest among Black (34.5%) and lowest among Whites (30.2%).Discussion. Results from this study show racial disparities in pedestrian injury hospitalization rates and outcomes, particularly among Black, Hispanic, and Multiracial/Other race/ethnicity groups and support population and system-level approaches to prevention. Access to transportation is an indicator for health disparity, and these results indicate that access to safe transportation also shows inequity by race/ethnicity.
Identification of potential biomarkers and candidate small molecule drugs in glioblastoma
Authors: Lu Wei-cheng , Xie Hui , Yuan Ce , Li Jin-jiang , Li Zhao-yang , Wu An-hua 
Published: August 2020

Abstract
Background and aims:Glioblastoma (GBM) is a common and aggressive primary brain tumor, and the prognosis for GBM patients remains poor. This study aimed to identify the key genes associated with the development of GBM and provide new diagnostic and therapies for GBM. Methods:Three microarray datasets (GSE111260, GSE103227, and GSE104267) were selected from Gene Expression Omnibus (GEO) database for integrated analysis. The differential expressed genes (DEGs) between GBM and normal tissues were identified. Then, prognosis-related DEGs were screened by survival analysis, followed by functional enrichment analysis. The protein-protein interaction (PPI) network was constructed to explore the hub genes associated with GBM. The mRNA and protein expression levels of hub genes were respectively validated in silico using The Cancer Genome Atlas (TCGA) and Human Protein Atlas (HPA) databases. Subsequently, the small molecule drugs of GBM were predicted by using Connectivity Map (CMAP) database. Results:A total of 78 prognosis-related DEGs were identified, of which10 hub genes with higher degree were obtained by PPI analysis. The mRNA expression and protein expression levels of CETN2, MKI67, ARL13B, and SETDB1 were overexpressed in GBM tissues, while the expression levels of CALN1, ELAVL3, ADCY3, SYN2, SLC12A5, and SOD1 were down-regulated in GBM tissues. Additionally, these genes were significantly associated with the prognosis of GBM. We eventually predicted the 10 most vital small molecule drugs, which potentially imitate or reverse GBM carcinogenic status. Cycloserine and 11-deoxy-16,16-dimethylprostaglandin E2 might be considered as potential therapeutic drugs of GBM. Conclusions:Our study provided 10 key genes for diagnosis, prognosis, and therapy for GBM. These findings might contribute to a better comprehension of molecular mechanisms of GBM development, and provide new perspective for further GBM research. However, specific regulatory mechanism of these genes needed further elaboration.
Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation
Authors: Zhu Jing , Zhu Qianqian , Huang Jialyu , Qiu Meiting , Zhu Yanwen , Cai Renfei , Kuang Yanping 
Published: August 2020

Abstract
The authors have withdrawn this preprint due to erroneous posting.