bluuebunny/crossref_metadata_2025_split huggingface dataset:
LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions
Authors: Oi Curran , Gidden Zoe , Holyoake Louise , Kantelberg Owen , Mochrie Simon , Horrocks Mathew H. , Regan Lynne 
Published: August 2020

AbstractWe present LIVE-PAINT, a new approach to super-resolution fluorescent imaging inside live cells. In LIVE-PAINT only a short peptide sequence is fused to the protein being studied, unlike conventional super-resolution methods, which rely on directly fusing the biomolecule of interest to a large fluorescent protein, organic fluorophore, or oligonucleotide. LIVE-PAINT works by observing the blinking of localized fluorescence as this peptide is reversibly bound by a protein that is fused to a fluorescent protein. We have demonstrated the effectiveness of LIVE-PAINT by imaging a number of different proteins inside live S. cerevisiae. Not only is LIVE-PAINT widely applicable, easily implemented, and the modifications minimally perturbing, but we also anticipate it will extend data acquisition times compared to those previously possible with methods that involve direct fusion to a fluorescent protein.
X-ray study of the merging galaxy cluster Abell 3411-3412 with XMM-Newton and Suzaku
Authors: Zhang X. , Simionescu A. , Akamatsu H. , Kaastra J. S. , de Plaa J. , van Weeren R. J. 
Published: August 2020

Context. Previous Chandra observations of the Abell 3411-3412 merging galaxy cluster system revealed an outbound bullet-like sub-cluster in the northern part and many surface brightness edges at the southern periphery, where multiple diffuse sources are also reported from radio observations. Notably, a southeastern radio relic associated with fossil plasma from a radio galaxy and with a detected X-ray edge provides direct evidence of shock re-acceleration. The properties of the reported surface brightness features have yet to be constrained from a thermodynamic viewpoint.
Aims. We use the XMM-Newton and Suzaku observations of Abell 3411-3412 to reveal the thermodynamical nature of the previously reported re-acceleration site and other X-ray surface brightness edges. We also aim to investigate the temperature profile in the low-density outskirts with Suzaku data.
Methods. We performed both imaging and spectral analysis to measure the density jump and the temperature jump across multiple known X-ray surface brightness discontinuities. We present a new method to calibrate the vignetting function and spectral model of the XMM-Newton soft proton background. Archival Chandra, Suzaku, and ROSAT data are used to estimate the cosmic X-ray background and Galactic foreground levels with improved accuracy compared to standard blank sky spectra.
Results. At the southeastern edge, temperature jumps revealed by both XMM-Newton and Suzaku point to a ℳ ∼ 1.2 shock, which agrees with the previous result from surface brightness fits with Chandra. The low Mach number supports the re-acceleration scenario at this shock front. The southern edge shows a more complex scenario, where a shock and the presence of stripped cold material may coincide. There is no evidence for a bow shock in front of the northwestern “bullet” sub-cluster. The Suzaku temperature profiles in the southern low-density regions are marginally higher than the typical relaxed cluster temperature profile. The measured value kT500 = 4.84 ± 0.04 ± 0.19 keV with XMM-Newton and kT500 = 5.17 ± 0.07 ± 0.13 keV with Suzaku are significantly lower than previously inferred from Chandra.
Genetisch bedingte Hauterkrankungen – Xeroderma pigmentosum und das CEDNIK-Syndrom
Authors: Martens M. C. , Boeckmann L. , Emmert S. 
Published: August 2020

ZusammenfassungDie Rostocker Hautklinik ist Europäisches Referenznetzwerkzentrum für seltene Hauterkrankungen mit den besonderen Schwerpunkten Xeroderma pigmentosum und Ichthyosen. Diese Themen vertreten wir auch in der medizinischen Grundlagenforschung.Xeroderma pigmentosum (XP) ist eine seltene, autosomal-rezessive Erkrankung, die entsprechend der Gendefekte in 7 Komplementationsgruppen – XP-A bis XP-G sowie die sog. XP-Variante (XP-V) – eingeteilt wird. XP ist ein Nukleotid-Exzisions-Reparatur-Defektsyndrom und äußert sich v. a. durch vorzeitige Hautalterung und frühzeitige Entwicklung von Hauttumoren.Das seltene, neurokutane CEDNIK-Syndrom ist eine autosomal-rezessive Erkrankung, der eine Loss-of-Function-Mutation in SNAP29 zugrunde liegt. SNAP29 ist ein SNARE-Protein und an intrazellulären Membranfusionen beteiligt. CEDNIK ist ein Akronym für den mit dem Syndrom assoziierten Symptomkomplex aus zerebraler Dysgenese, Neuropathie, Ichthyose und Palmoplantarkeratosen. CEDNIK-Patienten weisen neben der Ichthyose zudem Gedeihstörungen, eine psychomotorische Retardierung und faziale Dysmorphien auf.
Motivationale und Volitionale Kurzintervention zur Steigerung der körperlichen Aktivität in der Entwöhnungsbehandlung von Abhängigkeitserkrankten (MoVo-EvA)
Authors: Chermette Chloé , Krumpen Sophia , von Au Sabrina 
Published: August 2020

ZusammenfassungNur wenigen Erwachsenen gelingt es, den gesundheitsförderlichen Bewegungs-Mindestempfehlungen der Weltgesundheitsorganisation zu entsprechen. Menschen mit psychischen Erkrankungen, wie beispielsweise Menschen mit einer Abhängigkeitserkrankung, fällt es oft noch schwerer, ausreichend körperlich aktiv zu sein [1]. Während Patient*innen in stationärer Versorgung die Mindestempfehlung körperlich-sportlicher Aktivität erreichen, ist es eine große Herausforderung, diese positiven Adaptionen über die stationäre Rehabilitation hinaus langfristig aufrechtzuerhalten [2]. Das Anliegen dieses Beitrags ist es, die theoriegeleitete Kurzintervention MoVo-EvA zur Steigerung der poststationären körperlichen Aktivität im Rahmen einer medizinischen Entwöhnungsbehandlung von abhängigkeitserkrankten Menschen vorzustellen. Weiterhin werden auf Grundlage von Erkenntnissen aus einem Pilotprojekt allgemeine, personelle, organisatorische und strukturelle Umsetzungshinweise für die Implementierung der MoVo-EvA-Intervention in Rehabilitationskliniken dargestellt.
Digitale Gesundheitsangebote für Kinder
Authors: Lampert Claudia 
Published: August 2020

ZUSAMMENFASSUNGDurch die Digitalisierung haben sich vielfältige Möglichkeiten für die Vermittlung gesundheitsbezogener Inhalte sowie für das gesundheitliche Selbstmanagement ergeben. Unterhaltsam gestaltete Anwendungen werden als Chance gesehen, insbesondere Kinder für gesundheitsbezogene Themen zu sensibilisieren oder gesundheitsfördernde Verhaltensweisen zu unterstützen. Der Beitrag gibt einen Überblick über verschiedene digitale Angebotstypen sowie deren Potenziale und Grenzen. Bislang liegen nur sehr wenige Studien zum Angebot und zur Nutzung digitaler Gesundheitsangebote vor. Verlässliche Angaben zum Umfang und zur Qualität des Angebots fehlen ebenso wie Daten zum Stellenwert von Gesundheitsangeboten im Medienrepertoire von Kindern. Bei der Auseinandersetzung mit diesem Thema müssen auch die Eltern einbezogen werden, da sie bei den jüngeren Nutzergruppen noch einen hohen Einfluss auf die Angebotsauswahl und Mediennutzung haben. Eltern benötigen niedrigschwellige Informations- und Orientierungsangebote, um eine informierte Auswahl treffen zu können sowie digitale Gesundheitskompetenzen, um Angebote hinsichtlich ihrer Qualität beurteilen und z. B. Gesundheitsdaten und daraus resultierende Empfehlungen richtig interpretieren und einordnen zu können.
Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum
Authors: Devi Asshaima Paramita , Duong Thuc-Huy , Ferron Solenn , Beniddir Mehdi A. , Dinh Minh-Hiep , Nguyen Van-Kieu , Pham Nguyen-Kim-Tuyen , Mac Dinh-Hung , Boustie Joël , Chavasiri Warinthorn , Pogam Pierre Le 
Published: August 2020

AbstractThree new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.
Die diabetische Angiopathie
Authors: Rittig Kilian 
Published: August 2020

ZUSAMMENFASSUNGDie massiv steigenden Zahlen der Diabeteserkrankung in Deutschland und weltweit sowie die damit vergesellschaftete Steigerung der mikro- und makrovaskulären Komplikationen dieser Patienten stellt ein massives gesundheitspolitisches und volkswirtschaftliches Problem dar. Noch vor wenigen Jahren standen uns zur medikamentösen Therapie dieser Patienten im Wesentlichen nur Substanzen zur Verfügung, für die kein oder nur ein geringer Nutzen im Hinblick auf die Reduzierung des kardiovaskulären Risikos belegt war. Die Höhe des HbA1c-Werts war die einzige Richtschnur für die Einschätzung der Güte der Einstellung des Glukosestoffwechsels. Seit einigen Jahren stehen jedoch zunehmend Substanzen zur Verfügung, für die ein positiver Effekt auf das kardiovaskuläre Überleben der Diabetespatienten eindrücklich belegt wurde, und die seitdem Einzug in den klinischen Alltag gehalten haben. Vor allem die Einführung der GLP-1-Rezeptoragonisten und der SGLT-2-Inhibitoren haben uns hier ganz neue Therapiemöglichkeiten eröffnet. Auch im Hinblick auf die Diagnostik einer Atherosklerose, insbesondere der pAVK, gilt es bei Menschen mit Diabetes einige Besonderheiten zu beachten, auf die in dieser Übersicht eingegangen wird. Die stetig steigende Zahl der Diabetespatienten mit und ohne Gefäßkomplikationen stellt das Gesundheitssystem und uns Behandler vor gravierende Herausforderungen, die in den nächsten Jahren noch wachsen werden. Diesen werden wir nur gemeinsam und interdisziplinär begegnen können.
The Importance of Clinical Presentation in Risk and Management of Recurrent Preterm Birth
Authors: Smith Devin D. , Finneran Matthew M. , Shellhaas Cynthia C. , Samuels Philip , Frey Heather A. 
Published: August 2020

Objective This study aimed to compare the risk of recurrent spontaneous preterm birth (sPTB), as well as cerclage efficacy, between groups stratified by phenotype of the index sPTB.
Study Design This is a retrospective cohort study of women with a history of sPTB. Included were women with a history of singleton sPTB who received progesterone in a subsequent pregnancy. Multifetal gestations and abdominal cerclage were excluded. Exposure groups were based upon the presenting symptom that preceded their first sPTB and included painless cervical dilation (PCD), preterm premature rupture of membranes (PPROM), and painful dilation (preterm labor [PTL]). Primary outcome was delivery <34 weeks in a subsequent pregnancy. Secondary outcomes included delivery <28 and <37 weeks. Rates were compared using the Chi-square test. Multivariable Poisson regression was used to adjust for confounders.
Results A total of 723 women were included. A total of 114 (16%) presented with PCD, 305 (42%) with PPROM, and 304 (42%) with PTL in their first sPTB. Cerclage in subsequent pregnancy was highest in the PCD group (42%) when compared with the PPROM (16%) and PTL (12%) groups. Rates of sPTB <34 and 37 weeks were similar among the groups. After adjusting for confounders, PCD was found to significantly increase the risk of recurrent sPTB <28 weeks (incidence rate ratio: 3.46 [1.09–11.0]; p = 0.04). Of the 121 women who underwent cerclage, there were no significant differences in rates of sPTB between the clinical presentation groups.
Conclusion PCD as a specific phenotype of sPTB impacts recurrence of delivery before 28 weeks, but not at later gestational ages. In contrast, there was no significant association between clinical presentation of index sPTB and gestational latency in women who also underwent cerclage placement in a subsequent pregnancy. Our data suggest that clinical presentation is important with regards to recurrence of early sPTB, but not sPTB at later gestational ages.
Key Points
Low Variability of Blood Pressure Predicts Abnormal Electroencephalogram in Infants with Hypoxic Ischemic Encephalopathy
Authors: Flower Abigail , Vasiliu Daniel , Zhu Tianrui , Andris Robert , Abubakar Maryam , Fairchild Karen , Zanelli Santina , Matsumoto Julie , Mathur Amit M. , Delos John , Vesoulis Zachary 
Published: August 2020

Objective This study aimed to evaluate the role of an objective physiologic biomarker, arterial blood pressure variability, for the early identification of adverse short-term electroencephalogram (EEG) outcomes in infants with hypoxic-ischemic encephalopathy (HIE).Study Design In this multicenter observational study, we analyzed blood pressure of infants meeting these criteria: (1) neonatal encephalopathy determined by modified Sarnat exam, (2) continuous mean arterial blood pressure (MABP) data between 18 and 27 hours after birth, and (3) continuous EEG performed for at least 48 hours. Adverse outcome was defined as moderate–severe grade EEG at 48 hours. Standardized signal preprocessing was used; the power spectral density was computed without interpolation. Multivariate binary logistic regression was used to identify which MABP time and frequency domain metrics provided improved predictive power for adverse outcomes compared with standard clinical predictors (5-minute Apgar score and cord pH) using receiver operator characteristic analysis.Results Ninety-one infants met inclusion criteria. The mean gestational age was 38.4 ± 1.8 weeks, the mean birth weight was 3,260 ± 591 g, 52/91 (57%) of infants were males, the mean cord pH was 6.95 ± 0.21, and 10/91 (11%) of infants died. At 48 hours, 58% of infants had normal or mildly abnormal EEG background and 42% had moderate or severe EEG backgrounds. Clinical predictor variables (10-minute Apgar score, Sarnat stage, and cord pH) were modestly predictive of 48 hours EEG outcome with area under curve (AUC) of 0.66 to 0.68. A composite model of clinical and optimal time- and frequency-domain blood pressure variability had a substantially improved AUC of 0.86.Conclusion Time- and frequency-domain blood pressure variability biomarkers offer a substantial improvement in prediction of later adverse EEG outcomes over perinatal clinical variables in a two-center cohort of infants with HIE.Key Points
The influence of expatriate cultural intelligence on organizational embeddedness and knowledge sharing: The moderating effects of host country context
Authors: Stoermer Sebastian , Davies Samuel , Froese Fabian Jintae 
Published: August 2020

AbstractThis study advances our understanding of the contextualization of the effects of cultural intelligence (CQ). Drawing from trait activation theory and institutional theory, we develop a multi-level model showing how host countries’ informal and formal openness towards foreigners facilitate or constrain the importance of expatriates’ CQ in becoming embedded in the host organization. Furthermore, this study positions organizational embeddedness as a mediator in the association between expatriates’ CQ and a central element of expatriates’ jobs – knowledge sharing in the foreign workplace. Results from a cross-lagged survey of 1327 expatriates from 100 different nations residing in 30 host countries combined with secondary data indicate expatriate CQ relates positively to organizational embeddedness. Cross-level interaction analyses further suggest that in-group collectivism, the proxy for host countries’ informal openness towards foreigners, facilitates the importance of CQ as a predictor of expatriates’ organizational embeddedness. In contrast, CQ was not found to interact with the proxy for host countries’ formal openness towards foreigners, i.e. national immigration policies. Consistent with predictions, we identified that CQ relates positively to knowledge sharing and that organizational embeddedness carries an indirect effect. We discuss the implications for theory and practice.
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine
Authors: Tillman Matthew C. , Imai Norihiro , Li Yue , Khadka Manoj , Okafor C. Denise , Juneja Puneet , Adhiyaman Akshitha , Hagen Susan J. , Cohen David E. , Ortlund Eric A. 
Published: August 2020

Significance
Brown adipose tissue (BAT) burns fat to maintain body temperature through thermogenesis in mammals. Because heat production requires metabolizing large amounts of calories, increasing the activity of the tissue could treat obesity and related metabolic disorders. Recently, thioesterase superfamily member 1 (Them1) was identified to suppress thermogenesis, whereas deletion of Them1 enhanced the ability of BAT to burn fat and prevented diet-induced obesity. In this study, we show Them1 contains a lipid sensor that binds to fatty acids and lysophosphatidylcholine, which inversely regulate the activity of Them1. This lipid sensor allows for allosteric control of Them1 activity to regulate the burning of fat. Additionally, this study affirms a promising drug target to treat obesity and related disorders.
Impartiality and accuracy as a case in point while interpreting in a refugee context
Authors: Jiménez Ivars Amparo 
Published: August 2020

AbstractThis paper examines the fundamentals of professionalism focusing on the code of ethics as a pivotal parameter. Attention is paid to the difficulties of implementing two of the core principles of codes of ethics for interpreting in a refugee context: impartiality and accuracy. The aim of this article is to explore interpreters’ appreciation of these principles and self-identification with them versus actual observance in refugee settings. Ninety-six US-based interpreters completed a survey on self-perceptions regarding adherence to the principles and real actions performed. Findings show that a high number of interpreters do not comply with the principles despite having previously declared their full endorsement and self-identification with them. Impartiality presented more deviations than accuracy. Internal and external demands have proven to be stronger than adherence to the code. Calls to rethink and refine codes of ethics for interpreting in a refugee context are also presented.
Hopf link volume simplicity constraints in spin foam models
Authors: Assanioussi Mehdi , Bahr Benjamin 
Published: August 2020

Abstract
In this article we consider specific bivector geometries which arise in the large-spin limit of the extension of the Engle–Pereira–Rovelli–Livine spin foam model for quantum gravity by Kaminski, Kisielowski and Lewandowski. We address the implementation of volume simplicity constraints, which are required to ensure that a 4d metric can be reconstructed from the bivector geometry. We find that the necessary conditions are closely related, but not quite equal to the Hopf link volume simplicity constraints introduced in earlier works. We estimate the number of independent geometricity conditions for arbitrary bivector geometries, and find that they always agree with the number of Hopf links on the graph minus one, suggesting that the geometricity conditions can generically be formulated by deformation of the Hopf link volume simplicity constraints.
pygiftgenerator: a python module designed to prepare Moodle-based quizzes
Authors: Sáenz Jon , Gurtubay Idoia G , Izaola Zunbeltz , López Gabriel A 
Published: August 2020

Abstract
We present pygiftgenerator, a python module for systematically preparing a large number of numerical and multiple-choice questions for Moodle-based quizzes oriented to students’ formative evaluation. The use of the module is illustrated by means of examples provided with the code and drawn from different topics, such as mechanics, electromagnetism, thermodynamics and modern physics. The fact that pygiftgenerator relies on a well-established computer language, which allows functions to be combined and reused in order to solve complex problems, makes it a very robust tool. Simply by changing the input parameters, a large question bank with solutions to complex physical problems, can be generated. Thus, it is a powerful alternative to the calculated and multiple-choice questions which can be written directly in the Moodle platform. The module writes questions to be imported into Moodle and produces simple and human-readable ASCII output using the GIFT format, which enables html definitions for URLs for importing figures, or for simple text formatting (sub/superindices or Greek letters) for equations and units. This format also allows LaTeX and MathJax typing for complex equations.
Investigation of extreme ultraviolet spectra from highly charged holmium ions in 1
μ
m laser-produced plasmas
Authors: Wu Tao , Kawasaki Hiromu , Shimada Yuta , Higashiguchi Takeshi , O’Sullivan Gerry 
Published: August 2020

Abstract
Absolute intensity calibrated extreme ultraviolet spectra radiated by highly charged holmium (Ho) ions from 1 μm Nd:YAG laser generated plasmas in the 1–8 nm wavelength spectral range were measured and investigated. The spectral features show a broad structured continuum-like emission band, most prominent in the wavelength range 6–8 nm, which accounts for more than half of the emitted power. Assuming local thermodynamic equilibrium (LTE) in the laser produced plasmas and using the flexible atomic code and Cowan suite of codes, the wavelengths and LTE-gA values of unresolved transition arrays (UTAs) from E
1-contributing transition arrays 4p–4d, 4d–4f and super transition arrays such as 4p64d
k−14f + 4p54d
k+1–4p64d
k−24f2 + 4p44d
k+2 + 4p54d
k
4f and 4d10(5s5p)
k
4f
m−k
–4d9(5s5p)
k
4f
m−k+1 were calculated and shown to be responsible for the strongest observed spectral structure. Transitions between these excited to excited states are considered, since even if only weakly present, they will not be influenced by opacity effects unlike resonance transitions involving ground configurations. Another two intense continuous emission bands at 3–6 nm and 2–3 nm that dominate the spectra in the shorter wavelength range mainly arise from 4d–5p, 4d5s–4d5s5p, 4f–5g, 4f5s–4f5s5g and 4d–5f, 4d5s–4d5s5f, 4p–5s transitions. Spectral line shape parameters of Gaussian fits to the LTE-gA weighted radiation spectra of each Ho ion were given, enabling direct explanation of recorded spectra. Based on the LTE-gA UTAs formalism parameters, reasonable agreement is obtained between the synthetic spectrum and experimental result enabling some of the observed spectral features to be identified.
Benchmark calculations of ro-vibrational spectrum of HeH
−
and its isotopologues
Authors: Palikot Ewa , Stanke Monika , Adamowicz Ludwik 
Published: August 2020

Abstract
Benchmark variational calculations of the Born–Oppenheimer potential energy curve (PEC) performed with explicitly correlated all-electron Gaussian functions with shifted centers are presented. The PEC energies include the leading relativistic and quantum-electrodynamics corrections and the first-order corrections due to adiabatic effects. The PEC is used to calculate the ro-vibrational spectra for HeH− and its isotopologues. The results show that these systems are marginally stable and have two to four bound vibrational levels and, for each vibrational level, a few bound rotational levels lying below the dissociation threshold. This indicates a possibility of detecting the HeH− anion in the laboratory and, perhaps, even in the interstellar space.