bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Green Bridge - Wildlife Crossing Bridges of New Generation
Authors: Žák Jaroslav , Kraus Michal , Machová Petra , Plachý Jan 
Published: February 2020

Abstract
The research content of the paper is focused on landscape-vegetation and technical-economic optimization of vegetation elements of buildings. The length of the motorway in the Czech Republic has increased approximately three times since 1995. Road transport infrastructure is constantly growing. Ensuring the passage of important transport structures for fauna is an objective requirement. The function of migration corridors is ensured by wildlife crossing bridge. These constructions are currently based on concrete and steel, which is not only environmentally friendly but also presents several other problems. The paper presents the idea of a new smart solution for wildlife crossing bridge. Smart Green Bridge is based on principles and technologies following the sustainable development such as the use of load-bearing timber structures, extensive greenery of about 100 mm thickness, vertical greenery, self-guiding vertical and horizontal irrigation systems, photovoltaic panels, battery energy storage and next.
Application of Modeling Processes and 3D Print on Casting Molds for Concrete Furniture
Authors: Šál Jiří , Dědič Martin 
Published: February 2020

Abstract
The paper describes the practical use of modeling processes and 3D printing for the production of furniture, decorative and other objects. Using 3D modeling and printing on a 3D printer, it is possible to create a mold and subsequent product with a much more complex shape than would be possible with hand-made formwork or mold, or at least much simpler. Demonstration of applicability of these molds was carried out by an experimental method when the molds were poured out by cement or concrete from the fine aggregate. The forms themselves were formed from PLA filament. Experiments have shown the usability of such molds for complex concrete elements. These forms can be reused. Damage to the molds occurred during handling or cleaning, i.e. rough handling. During the filling itself and the process of cement hydration, they were not damaged. For a longer mold life, it is necessary to print in a larger percentage of filling, which, however, makes the mold more expensive. The durability of molds and better formwork is obtained by using formwork oil.
Extraordinary Hall balance in ultrathin SrRuO3 bilayers
Authors: van Thiel T C , Groenendijk D J , Caviglia A D 
Published: February 2020

Abstract
The correlated 4d transition metal oxide SrRuO3 (SRO) features an anomalous Hall effect that originates from momentum-space sources of Berry curvature and depends sensitively on the magnetization. Here, we exploit this sensitivity and realize an epitaxial extraordinary Hall balance device, consisting of two ultrathin layers of SRO, separated by an insulating SrTiO3 (STO) spacer. Our results highlight the potential of ultrathin SRO in the realization of oxide-based spintronic devices.
In-Depth Study of a Nosocomial Outbreak Caused by Extensively Drug-Resistant Pseudomonas aeruginosa Using Whole Genome Sequencing Coupled With a Polymerase Chain Reaction Targeting Strain-Specific Single Nucleotide Polymorphisms
Authors: Acosta Fermín , Fernández-Cruz Ana , Maus Sandra R , Sola-Campoy Pedro J , Marín Mercedes , Cercenado Emilia , Sierra Olalla , Muñoz Patricia , García de Viedma Darío , Pérez-Lago Laura 
Published: February 2020

Abstract
In 2013–2014, an outbreak involving 14 patients infected by an extensively drug-resistant strain of Pseudomonas aeruginosa was detected in a hospital in Madrid, Spain. Our objective was to evaluate an alternative strategy for investigating the outbreak in depth by means of molecular and genomic approaches. Pulsed-field gel electrophoresis (PFGE) was applied as a first-line approach, followed by a more refined whole genome sequencing analysis. Single nucleotide polymorphisms identified by whole genome sequencing were used to design a specific polymerase chain reaction (PCR) for screening unsuspected cases infected by the outbreak strain. Whole genome sequencing alerted us to the existence of greater genetic diversity than was initially assumed, splitting the PFGE-associated outbreak isolates into 4 groups, 2 of which represented coincidental transmission unrelated to the outbreak. A multiplex allele-specific PCR targeting outbreak-specific single nucleotide polymorphisms was applied to 290 isolates, which allowed us to identify 25 additional cases related to the outbreak during 2011–2017. Whole genome sequencing coupled with an outbreak-strain-specific PCR enabled us to markedly redefine the initial picture of the outbreak by 1) ruling out initially suspected cases, 2) defining likely independent coincidental transmission events, 3) predating the starting point of the outbreak, 4) capturing new unsuspected cases, and 5) revealing that the outbreak was still active.
Circulating let-7g-5p and miR-191-5p Are Independent Predictors of Chronic Kidney Disease in Hypertensive Patients
Authors: Berillo Olga , Huo Ku-Geng , Fraulob-Aquino Júlio C , Richer Chantal , Briet Marie , Boutouyrie Pierre , Lipman Mark L , Sinnett Daniel , Paradis Pierre , Schiffrin Ernesto L 
Published: February 2020

Abstract

BACKGROUND
Hypertension (HTN) is associated with target organ damage such as cardiac, vascular, and kidney injury. Several studies have investigated circulating microRNAs (miRNAs) as biomarkers of cardiovascular disease, but few have examined them as biomarker of target organ damage in HTN. We aimed to identify circulating miRNAs that could serve as biomarkers of HTN-induced target organ damage using an unbiased approach.

METHODS AND RESULTS
Fifteen normotensive subjects, 16 patients with HTN, 15 with HTN associated with other features of the metabolic syndrome (MetS), and 16 with HTN or chronic kidney disease (CKD) were studied. Circulating RNA extracted from platelet-poor plasma was used for small RNA sequencing. Differentially expressed (DE) genes were identified with a threshold of false discovery rate &lt;0.1. DE miRNAs were identified uniquely associated with HTN, MetS, or CKD. However, only 2 downregulated DE miRNAs (let-7g-5p and miR-191-5p) could be validated by reverse transcription-quantitative PCR. Let-7g-5p was associated with large vessel stiffening, miR-191-5p with MetS, and both miRNAs with estimated glomerular filtration rate (eGFR) and neutrophil and lymphocyte fraction or number and neutrophil-to-lymphocyte ratio. Using the whole population, stepwise multiple linear regression generated a model showing that let-7g-5p, miR-191-5p, and urinary albumin/creatinine ratio predicted eGFR with an adjusted R2 of 0.46 (P = 8.5e−7).

CONCLUSIONS
We identified decreased circulating let-7g-5p and miR-191-5p as independent biomarkers of CKD among patients with HTN, which could have pathophysiological and therapeutic implications.
Predictors of Readmission Following Outpatient Treatment for Alcohol Use Disorder
Authors: Hansen Emmanuel Mangkornkaew , Mejldal Anna , Nielsen Anette Søgaard 
Published: February 2020

AbstractAimsTo identify predictors of readmission to outpatient treatment for alcohol use disorder (AUD) with a view to identifying underlying mechanisms for preventing relapse.MethodsA consecutive clinical cohort of 2130 AUD outpatients treated between 1 January 2006 and 1 June 2016 was studied. Data were collected by means of the Addiction Severity Index upon treatment entry and at discharge. Outcome measures were readmission to outpatient treatment and time to readmission. Potential predictors were tested for significance using Cox Proportional Hazards multivariate analysis.ResultsA total of 22% were readmitted during the follow-up time. Patients readmitted within 1 year of treatment conclusion differed significantly from those not readmitted on age, cohabitation status and completion status of index treatment. Significant predictors of readmission during follow-up time were younger age (hazard ratio (HR) = 0.99, 95% confidence interval (CI), 0.98–1.00), history of psychiatric illness (HR = 1.24, 95% CI, 1.02–1.50), drop-out from index treatment (HR = 1.41, 95% CI, 1.15–1.72) and length of index treatment (HR = 1.02, 95% CI, 1.00–1.04).ConclusionPremature drop-out from treatment, a history of psychiatric illness, younger age and longer treatment episodes appear to be the most important predictors of readmission.
What’s the Matter with Ohio? Liberal Democracy and the Challenge of Irrationality
Authors: Huehls Mitchum 
Published: February 2020

AbstractThis essay mines 100 years of fiction about the irrationalities of small-town Ohio to ask whether liberal democracy can accommodate irrationality or is required, because of its double commitment to equality and liberty, to exclude it. Reading novels from Sherwood Anderson, William Gass, and Stephen Markley, I trace a trajectory from the late nineteenth century of Anderson’s Winesburg, Ohio (1919), when irrationality partially grounded liberal community, to the twenty-first century of Markley’s Ohio (2018), when the irrationalities of violence, addiction, racism, and abuse constitute what I call “piteous solidarity,” a form of solidarity grounded on our shared inhumanity. I conclude by speculating that such piteous solidarity might represent “the mobilization of common affects in defense of equality and social justice” that Chantal Mouffe has recently argued is necessary for constituting the “we” of a left populism.
rMSIproc: an R package for mass spectrometry imaging data processing
Authors: Ràfols Pere , Heijs Bram , del Castillo Esteban , Yanes Oscar , McDonnell Liam A , Brezmes Jesús , Pérez-Taboada Iara , Vallejo Mario , García-Altares María , Correig Xavier 
Published: February 2020

Abstract

Summary
Mass spectrometry imaging (MSI) can reveal biochemical information directly from a tissue section. MSI generates a large quantity of complex spectral data which is still challenging to translate into relevant biochemical information. Here, we present rMSIproc, an open-source R package that implements a full data processing workflow for MSI experiments performed using TOF or FT-based mass spectrometers. The package provides a novel strategy for spectral alignment and recalibration, which allows to process multiple datasets simultaneously. This enables to perform a confident statistical analysis with multiple datasets from one or several experiments. rMSIproc is designed to work with files larger than the computer memory capacity and the algorithms are implemented using a multi-threading strategy. rMSIproc is a powerful tool able to take full advantage of modern computer systems to completely develop the whole MSI potential.

Availability and implementation
rMSIproc is freely available at https://github.com/prafols/rMSIproc.

Contact
pere.rafols@urv.cat

Supplementary information
Supplementary data are available at Bioinformatics online.
The 1983 Strike-Hard Campaign in China: a Moral Panic?
Authors: Dai Mengliang 
Published: February 2020

AbstractThough more than three decades have passed since the launch of Strike Hard in 1983, its impact on crimes remains. Most of the literature on the campaign so far has been theoretically and methodologically limited. Using historical materials and interview data, this paper establishes an integrated theoretical framework and aims at investigating whether and how a moral panic was constructed. This study argues that the top leader played a decisive role in engineering the moral panic during the 1983 Strike Hard operated through a top-down approach under the Chinese political structure. In short, exploring events from the perspective of moral panic, this study gives a deep insight into the Chinese criminal justice system in response to crimes.
Simultaneous Quantitative Analysis of Multiple Biotransformation Products of Xian-Ling-Gu-Bao, a Traditional Chinese Medicine Prescription, with Rat Intestinal Microflora by Ultra-Performance Liquid Chromatography Tandem Triple Quadrupole Mass Spectrometry
Authors: Tang Xi-Yang , Gao Meng-Xue , Xiao Hui-Hui , Yun Wei-Jing , Dai Yi , Yao Zhi-Hong , Wong Man-Sau , Yao Xin-Sheng 
Published: February 2020

Abstract
Xian-Ling-Gu-Bao (XLGB), a famous traditional Chinese medicine prescription consisted of six herbal medicines, was used for prevention and treatment of osteoporosis in China. As an oral formulation, the multiple components contained in XLGB were inevitably biotransformed by the intestinal microflora before absorption via the gastrointestinal tract. However, the dynamic profiles of biotransformation products of XLGB remain unknown. In this paper, a rapid and sensitive ultra-performance liquid chromatography tandem triple quadrupole mass spectrometry method was developed for the simultaneous quantitative analysis of multiple biotransformation products of XLGB with rat intestinal microflora. For 10 selected quantitative compounds, all calibration curves revealed good linearity (r2 &gt; 0.99) within the sampling ranges considered. The whole intra- and inter-day precisions (as relative standard deviation) of all analytes were &lt;13.5%, and the accuracies (as relative error) were in the range from −11.3 to 11.2%. The lower limits of quantification were 20, 10, 5, 20, 2, 2, 2, 5, 2 and 2 ng/mL for sweroside, timosaponin BII, epimedin C, asperosaponin VI, psoralen, isobavachin, icariside II, timosaponin AIII, isobavachalcone and icaritin, respectively. The matrix effects, extraction recoveries and stabilities were all satisfactory. Meanwhile, dynamic profiles of 21 additional biotransformation products were also monitored by their area-time curves. The analytical method was successfully applied to describe dynamic profiles of 31 biotransformation products of XLGB and the recipes with removal of a definite composed herbal medicine (Anemarrhenae Rhizoma or Rehmanniae Radix).
Testing a key assumption of using drones as frightening devices: Do birds perceive drones as risky?
Authors: Egan Conor C , Blackwell Bradley F , Fernández-Juricic Esteban , Klug Page E 
Published: February 2020

AbstractWildlife managers have recently suggested the use of unmanned aircraft systems or drones as nonlethal hazing tools to deter birds from areas of human-wildlife conflict. However, it remains unclear if birds perceive common drone platforms as threatening. Based on field studies assessing behavioral and physiological responses, it is generally assumed that birds perceive less risk from drones than from predators. However, studies controlling for multiple confounding effects have not been conducted. Our goal was to establish the degree to which the perception of risk by birds would vary between common drone platforms relative to a predator model when flown at different approach types. We evaluated the behavioral responses of individual Red-winged Blackbirds (Agelaius phoeniceus) to 3 drone platforms: a predator model, a fixed-wing resembling an airplane, and a multirotor, approaching either head-on or overhead. Blackbirds became alert earlier (by 13.7 s), alarm-called more frequently (by a factor of 12), returned to forage later (by a factor of 4.7), and increased vigilance (by a factor of 1.3) in response to the predator model compared with the multirotor. Blackbirds also perceived the fixed-wing as riskier than the multirotor, but less risky than the predator model. Overhead approaches mostly failed to elicit flight in blackbirds across all platform types, and no blackbirds took flight in response to the multirotor at either overhead or head-on approaches. Our findings demonstrate that birds perceived drones with predatory characteristics as riskier than common drone models (i.e. fixed-wing and multirotor platforms). We recommend that drones be modified with additional stimuli to increase perceived risk when used as frightening devices, but avoided if used for wildlife monitoring.
Pathobiology of pulmonary artery hypertension: role of long non-coding RNAs
Authors: Zahid Kashif Rafiq , Raza Umar , Chen Jidong , Raj Usha J , Gou Deming 
Published: February 2020

Abstract
Pulmonary arterial hypertension (PAH) is a disease with complex pathobiology, significant morbidity and mortality, and remains without a cure. It is characterized by vascular remodelling associated with uncontrolled proliferation of pulmonary artery smooth muscle cells, endothelial cell proliferation and dysfunction, and endothelial-to-mesenchymal transition, leading to narrowing of the vascular lumen, increased vascular resistance and pulmonary arterial pressure, which inevitably results in right heart failure and death. There are multiple molecules and signalling pathways that are involved in the vascular remodelling, including non-coding RNAs, i.e. microRNAs and long non-coding RNAs (lncRNAs). It is only in recent years that the role of lncRNAs in the pathobiology of pulmonary vascular remodelling and right ventricular dysfunction is being vigorously investigated. In this review, we have summarized the current state of knowledge about the role of lncRNAs as key drivers and gatekeepers in regulating major cellular and molecular trafficking involved in the pathogenesis of PAH. In addition, we have discussed the limitations and challenges in translating lncRNA research in vivo and in therapeutic applications of lncRNAs in PAH.
Mortality in trials on transcatheter aortic valve implantation versus surgical aortic valve replacement: a pooled meta-analysis of Kaplan–Meier-derived individual patient data
Authors: Barili Fabio , Freemantle Nicholas , Pilozzi Casado Alberto , Rinaldi Mauro , Folliguet Thierry , Musumeci Francesco , Gerosa Gino , Parolari Alessandro 
Published: February 2020

Abstract

OBJECTIVES
This meta-analysis of Kaplan–Meier-estimated individual patient data was designed to evaluate the effects of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) on the long-term all-cause mortality rate, to examine the potential time-varying effect and to model their hazard ratios (HRs) over time. Moreover, we sought to compare traditional meta-analytic tools and estimated individual patient data meta-analyses.

METHODS
Trials comparing TAVI versus SAVR were identified through Medline, Embase, Cochrane databases and specialist websites. The primary outcome was death from any cause at follow-up. Enhanced secondary analyses of survival curves were performed estimating individual patient time-to-event data from published Kaplan–Meier curves. Treatments were compared with the random effect Cox model in a landmark framework and fully parametric models.

RESULTS
We identified 6 eligible trials that included 6367 participants, randomly assigned to undergo TAVI (3252) or SAVR (3115). According to the landmark analysis, the incidence of death in the first year after implantation was significantly lower in the TAVI group [risk-profile stratified HR 0.85, 95% confidence interval (CI) 0.73–0.99; P = 0.04], whereas there was a reversal of the HR after 40 months (risk-profile stratified HR 1.31, 95% CI 1.01–1.68; P = 0.04) favouring SAVR over TAVI. This time-varying trend of HRs was also confirmed by a fully parametric time-to-event model. Traditional meta-analytic tools were shown to be biased because they did not intercept heterogeneity and the time-varying effect.

CONCLUSIONS
The mortality rates in trials of TAVI versus SAVR are affected by treatments with a time-varying effect. TAVI is related to better survival in the first months after implantation whereas, after 40 months, it is a risk factor for all-cause mortality.
Conducting a Community-Based ESOL Programme Needs Analysis
Authors: Feuerherm Emily , Oshio Toko 
Published: February 2020

Abstract
This article traces a community-based participatory action research (CBPAR) project which engaged local non-profits and the immigrant community in Flint, Michigan, USA, to identify areas for growth in support of local immigrant-background residents. Collaborative data-gathering began in 2015 with the creation of a community asset map which outlined existing services available to immigrants, as well as potential areas for growth. This was followed by a series of linguistically and culturally sensitive focus groups with immigrant-background participants. The use of CBPAR was foundational to this study because it engaged the local community in the needs analysis process and resulted in the development of grassroots ESOL programming. The article outlines steps and recommendations for community-based participatory ESOL needs analysis that can be applied to other geographical regions and ESOL programmes.
Science in support of ecologically sound decommissioning strategies for offshore man-made structures: taking stock of current knowledge and considering future challenges
Authors: Birchenough Silvana N R , Degraer Steven 
Published: February 2020

AbstractThe blue growth agenda has spurred an accelerating exploitation and continued development of the coastal and marine environment. This is also driven by the increasing need to generate renewable energy. In most cases, this has resulted in a large number of man-made structures (MMSs) across several soft sediment environments. The nature of these structures ranges from oil and gas installations to harbour walls, anchored buoys, pipelines and offshore wind farms. These structures host fouling communities that are often new to offshore regions, potentially serving as stepping stones for range-expanding (non-indigenous) species and providing habitat and shelter for a variety of marine species. The altered local biodiversity also affects biological and biogeochemical processes from the water column to the seafloor, either directly (e.g. scouring, organic matter export from piles) or indirectly (e.g. closure or displacement of fisheries) and, hence, ecosystem functioning at various spatial and temporal scales. A proper understanding of the effects of artificial hard substrate and the consequences of its removal (e.g. through decommissioning) to marine biodiversity has yet to develop to maturity. This themed article set contributes to the scientific knowledge base on the impacts of MMSs on marine ecosystems with the specific aim to fertilize and facilitate an evidence-based debate over decommissioning. This discussion will become ever more vital to inform marine spatial planning and future policy decisions on the use and protection of marine resources.
A Vanishing Associated With Irregular MSP Fields
Authors: Chang Huai-Liang , Li Jun 
Published: February 2020

AbstractIn [ 7] and [ 8], the notion of Mixed-Spin-P (MSP) fields is introduced and their ${\mathbb{C}}^\ast $-equivariant moduli space ${{\mathcal{W}}}_{g,\gamma ,{\textbf d}}$ is constructed. In this paper, we prove a vanishing of a class of localization terms in $[(\mathcal{W}_{g,\gamma ,\mathbf{d}})^{\mathbb{C}^*}]^{\textrm{vir}}$, which implies the only quintic FJRW invariants that contribute to the relations derived from the theory of MSP fields are those with pure insertions $2/5$. It is critical in a proof of BCOV Feynman sum formula for quintic Calabi–Yau three-folds.