bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemoglobin A1c Levels Affect Visit-to-visit Variability of Lipid Profiles in Patients Undergoing Elective Percutaneous Coronary Intervention: A Retrospective Study
Authors: Li Duanbin , Wang Cao , Zhao Liding , Luan Yi , Li Ya , Fu Guosheng , Chen Zhaoyang , Zhang Wenbin 
Published: November 2020

Abstract
BackgroundBoth hemoglobin A1c (HbA1c) levels and visit-to-visit variability of lipid profiles are risk factors for cardiovascular disease (CVD). We conducted a retrospective cohort study to explore the relationship between HbA1c and lipid variability.MethodsWe retrospectively collected baseline and follow-up data on patients who underwent elective percutaneous coronary intervention (PCI) from January 2009 to April 2019. Univariate and multivariate linear regression analyses were performed to assess the association between HbA1c and lipid variability. Subgroup analyses employed multivariate linear regression analyses.ResultsA total of 4,445 patients were enrolled in the study. The median age and value of HbA1c were 64yrs old and 5.9%, respectively, 64% had hypertension and 25.5% diabetes. The variability of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol (TC), and triglyceride (TG) was each significantly higher in patients with HbA1c≥6.5% than those with HbA1c＜6.5% group. Multivariate linear regression indicated that HbA1c level was a potential risk factor for the variability of LDL-C, non-HDL-C, TC and TG, which was independent of the mean values of lipids. Subgroup analyses demonstrated that the relationship between HbA1c and the variability of LDL-C, non-HDL-C, TC, and TG did not importantly vary across several subgroups. These results remained consistent when lipid variability was represented by the standard deviation (SD), coefficient of variation (CV) and variability independent of the mean (VIM), respectively.ConclusionHbA1c is a potential risk factor for the variability of LDL-C, non-HDL-C, TC and TG in patients undergoing elective PCI.
Contribution of Nontraditional Lipid Profiles to Hyperuricemia in Rural Chinese Hypertensive Population: Findings From the China Hypertension Registry Study
Authors: Yu Yu , Lan Tian , Wang Dandan , Fang Wangsheng , Tao Yu , Li Minghui , Huang Xiao , Zhou Wei , Wang Tao , Zhu Lingjuan , Bao Huihui , Cheng Xiaoshu 
Published: November 2020

Abstract
Background: Current studies support nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio, non-HDL-C] as reliable indicators of cardiovascular disease, stroke and diabetes. However, whether nontraditional lipid profiles can be used as reliable markers for hyperuricemia (HUA) remains unclear due to limited research. The present study investigated the relationship of nontraditional lipid profiles with HUA in hypertensive patients.Methods: We analyzed data from 13,721 Chinese hypertensive population untreated with lipid-lowering drugs. The relationship between non-traditional lipid profiles and HUA was examined by multivariate logistic regression analysis and smooth curve fitting (penalized spline method).Results: The results showed that there were positive associations of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C with HUA, respectively (all P <0.001). Furthermore, nontraditional lipid profiles were converted from continuous variables to tertiles. Compared with lowest tertile, the multivariate adjusted ORs (95% CI) of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio and non-HDL-C in highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), 1.93 (1.74, 2.13), respectively (all P <0.001).Conclusions: In Chinese hypertensive population, there were positive associations between nontraditional lipid profiles (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) and HUA. Our findings further expand the scope of application of nontraditional lipid profiles. These novel and important results suggest that nontraditional lipid profiles can be used as potential and valuable indicators of HUA, and provide a new strategy for the prevention and treatment of HUA.
Mental Health Status of Stable Hospitalized COVID-19 Patients in the Main COVID-19 Hospitals in Malaysia
Authors: Azlan Shaiful , Ahmad Noor Ani , Silim Umi Adzlin , Abdullah Muhammad Najib , Harun Norazam , Dollah Siti Nordiana , Sahril Norhafizah , Rezali Muhammad Solihin , Chan Ying Ying , Redzuan Noor Izuana , Salleh Adlin Mohd , Ishak Hariani , Aziz Salina Abdul , Chin Loi Fei , Lee Chung Wah , Rahman Norhayati Ab , Namal Marini , Som Suhaila Mohd , Dass Fabian Sunil , Badruddin Norhameza Ahmad , Ibrahim Nurashikin 
Published: November 2020

Abstract
BackgroundThe COVID-19 pandemic is catastrophic and caused negative psychological effects among patients, healthcare workers and their surroundings. This study aims to determine the prevalence of depression and general anxiety disorders (GAD) among stable hospitalized COVID-19 patients.MethodsA cross-sectional study via web-based online survey involving 401 patients in the main COVID-19 hospitals in Malaysia who were selected via quota sampling. The questionnaire consists of socio-demographic profile, Patient Health Questionnaire 9 items (PHQ-9), General Anxiety Disorders 7 items (GAD-7) and Brief COPE (Coping Orientation to Problems Experienced). The identified probable cases of depression, anxiety and suicidal ideation were subsequently referred to psychiatrists.ResultThe prevalence of depression and anxiety were 7.5% and 7.0%, respectively. Besides that, 4.0% of respondents were suspected as having suicidal ideation. The prediction model revealed that females [aOR=5.29 (95% CI: 1.34, 20.80)], age 35-49 years old [aOR=7.47 (95% CI: 1.78, 31.30)], adopting behavioral disengagement [aOR=1.94 (95% CI: 1.31, 2.87)] and self-blame [aOR= 1.74 (95% CI: 1.31, 2.30)] as coping strategies, were significant predictors of depression. ConclusionsThe findings estimate the mental health burden among COVID-19 patients in Malaysia. The establishment of continuous mental health surveillance is essential in managing cases of depression, anxiety and suicidal ideation.
Best First Line Tyrosine Kinase Inhibitor for Chronic Phase Chronic Myeloid Leukemia in Adults: A Network Meta-Analysis
Authors: Vener Claudia , Fattizzo Bruno , Ambrogi Federico , Saglio Giuseppe , Pravettoni Gabriella , Kopp-Heim Doris , Giovane Cinzia Del 
Published: November 2020

Abstract
BackgroundFor many years chronic myeloid leukemia (CML) remained a leukemic subtype in which little improvement was gained with regard to overall survival (OS). Imatinib, the first tyrosine kinase inhibitor (TKI), completely changed patients’ life expectancy. Although many studies have compared the use of imatinib and more recent TKIs in patients with newly diagnosed chronic phase (CP) CML, they have not established which is the most effective. Since there are no randomised controlled trials (RCTs) that compare head-to-head second- and third-generation TKIs, a network meta-analysis (NMA) is required to identify the best TKI to be preferably used. MethodsThis systematic review and NMA of RCTs will compare the efficacy and safety of imatinib vs second-generation (dasatinib, nilotinib, bosutinib) and third-generation TKIs (ponatinib) in adults with newly diagnosed Philadelphia Chromosome-Positive (Ph+) CP CML, concentrating on OS, progression-free survival (PFS), and hematological and non-hematological adverse events (AEs). The databases PubMed, EMBASE and Cochrane CENTRAL will be systematically searched, as well as other sources to identify published and unpublished studies. The risk of bias (RoB) of the included studies will be assessed using the Cochrane risk of bias tool; moreover, the confidence in network meta-analysis estimates will be evaluated with the CINeMA tool. DiscussionThe results of this systematic review and NMA are expected to suggest a specific TKI to be used for patients with newly CP CML. It remains valid that the choice of the optimal drug should consider AEs and co-morbidities as well as molecular/cytogenetic responses and transformation rates.Systematic review registrationThe review protocol PROSPERO registration number is: CRD42020190444. This protocol is written in accordance with the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The PRISMA-P checklist can be found in Additional file 1.
Natural xanthone compounds as promising drug candidates against COVID-19 - An integrated molecular docking and dynamics simulation study
Authors: Gunda Shravan Kumar , P Hima Kumari , Choudhir Gourav , Kumar Anuj , Kishor P B. Kavi , S Anil Kumar 
Published: November 2020

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease2019 (COVID-19). SARS-CoV-2 is known for its high pathogenicity and transmission due to thepresence of polybasic cleavage sites. No specific drug is available for the treatment. To identifythe potential inhibitors, we have performed molecular docking against the SARS-CoV-2 mainprotease (6Y84) with fifteen important natural xanthone compounds. The docking results showedall the compounds exhibited good binding energies and interactions with the main protease. Thevalidation of representative docking complexes through molecular dynamics simulations showedthat xanthones binds with a higher binding affinity and lower free energy than the standardligand with Brasixanthone C and Brasixanthone B on 50 ns. Natural xanthone compounds havealso passed the Absorption, Distribution, Metabolism, and Excretion (ADME) property criteriaas well as Lipinski’s rule of five. The present integrated molecular docking and dynamicssimulations study unveil the use of xanthones as potential antiviral agents against SARS-CoV-2.
Morphological plasticity in a wild freshwater fish,&nbsp;Systomus&nbsp;sarana&nbsp;(Cyprinidae) from India: a glimpse through advanced morphometric toolkits&nbsp;
Authors: Gupta Deepmala , Dwivedi Arvind Kumar , Tripathi Madhu 
Published: November 2020

Abstract
Background: Body morphology supposed to underpin wide differences in animal performance that can be used to understand the diversification of characters. Further, identifying the fish population with unique shape due to variations in their morphometric characters enable better management of these subunits. Advanced statistical toolkits of morphometry called truss network system and geometric morphometrics have been increasingly used for detecting variations in morphological traits between subunits of fish populations. The present study was therefore carried out with the objective of determining phenotypically distinct units of freshwater fish Systomus sarana collected from geographically isolated locations.Methods: In the present study, 154 specimens of olive barb, S. sarana were collected from four distantly located rivers covering the northern (Ganga), southern (Godavari), central (Narmada), and eastern (Mahanadi) regions of India. Truss-network system and geometric morphometrics have been utilized. Fourteen landmarks were digitized uniformly on each specimen. In the present study, the truss network system yielded size-corrected morphometric characters that were subjected to univariate and multivariate statistical assessment. Results: Analysis of variance (ANOVA) presented significant differences among 63 out of 90 variables (p<0.05). Truss approach includes principal component analysis (PCA) and discriminant function analysis (DFA) while the geometric approach includes PCA, DFA, canonical variate analysis (CVA), partial least square (PLS), the relative warp (RW), and wireframes. CVA extracted Mahalanobis and Procrustes distances among groups found to be highly significant (p<0.0001). In linear DFA, the overall assignment of correctly classified individuals into their original groups was 86.2% for Ganga, 86.1% for the Godavari, 93.9% for the Narmada, and 92.9% for the Mahanadi population. Conclusions: The results revealed significant variations in the morphometric characters which were reflected in the shape of different body features of the studied populations. Both methods revealed analogous results and significant differences among groups in examined features. Our results suggest that S. sarana shows morphological plasticity across different rivers in India. This study supports the concept that geographical isolation among fish populations can lead to morphological variations.
Ipsilateral midshaft clavicle fracture and acromioclavicular joint dislocation: a review of literature and evidence-based diagnosis guidelines
Authors: Ao Rongguang , Jian Zhen , Chen Jinhong , Li Dejian , Zhang Xu , Jiang Xinhua , Zhou Jianhua , yu baoqing 
Published: November 2020

Abstract
Background: Ipsilateral midshaft clavicle fracture and AC joint dislocation are rare, with very few cases reported. Once the AC joint dislocation were missed diagnosis, the shoulder function may be affected and medical dispute was easy to occur. The aim of this study was to gather data relating to ipsilateral midshaft clavicle fracture and AC joint dislocation to develop evidence-based diagnosis guidelines as none are currently available.Methods: A study was conducted of the PubMed and Google Scholar databases to identify cases of ipsilateral midshaft clavicle fracture and AC joint dislocation. Data collected about each case included age and gender of the patient, mechanism of injury, fracture and dislocation classification. The authors report 2 additional ipsilateral midshaft clavicle fracture and AC joint dislocation cases.Results: 21 cases were identified for inclusion in this research, 19 from the literature and 2 reported by the authors. All the patients were injured by high energy trauma. For the midshaft fracture, 16/21 (76.2%) patients belonged to Type A classification, and 5/21 (23.8%) patients belonged to Type B classification. For AC joint dislocation, 11/21 (47.6%) patients belonged to Type IV classification, 4/21 (19.0%) patients belonged to Type VI classification, 5/21 (23.8%) patients belonged to Type III classification and 1/21 (4.7%) patients belonged to Type V classification.Conclusions: There are limited data available about the diagnosis of ipsilateral midshaft clavicle fracture and AC joint dislocation. From the cases reviewed, we find that simple midshaft clavicle caused by high energy injuries may be associated with ipsilateral AC joint dislocation. Physical examination, careful observation of preoperative X-ray and fluoroscopy including the AC joint during operation were key to diagnose the injury. Level of Evidence Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
The role of MEFV gene in COVID 19 disease, as a protective factor
Authors: Salehzadeh Farhad , Shahbazifar Ehsan , Pourfarzi Farhad , Molatefi Rassol , Davarnia Behzad , Ahmadabadi Farzad 
Published: November 2020

Abstract
Background

In early 2020, an outbreak of pneumonia caused by a novel coronavirus became pandemic. This study evaluates the potential immune-genetically role of MEFV gene mutations in COVID 19 patients.
Methods

50 COVID 19 PCR positive patients who were hospitalized in COVID 19 referral centers between 1st of March to 30th of April in 2020 were evaluated for MEFV gene mutations using ARMS PCR and Sanger sequencing.
Results

MEFV gene mutations were found in 6 (12%) of the patients. No homozygote or compound heterozygote forms were detected. The total mutant allele frequency was 6%. The carrier rate was 12% which is significantly lower than previously studied rate of 25%. The most common MEFV variant was E148Q in 3 (6%). There was no mutant variant of MEFV gene among the expired patients. None of the MEFV gene mutant patients had FMF symptoms or positive family history of FMF disease.
Conclusion

Considering the high carrier rate of MEFV gene mutations in the eastern Mediterranean region and a significantly lower prevalence of these mutations in COVID 19 patients, it seems that MEFV gene mutations may have a protective role in incidence of the disease.
PROPRIEDADES ANTIOXIDANTES E EFEITOS ANTIMICROBIANOS DA KOMBUCHA: REVISÃO DA EVIDÊNCIA CIENTÍFICA
Authors: Mendonça Gislane Romano , Pereira Ana Lúcia Fernandes , Ferreira Adriana Gomes Nogueira , Santos Neto Marcelino , Dutra Richard Pereira , Abreu Virgínia Kelly Gonçalves 
Published: November 2020

A kombucha é uma bebida produzida a partir da fermentação de chás por culturas simbióticas de bactérias e leveduras. Esta bebida ganhou popularidade devido aos seus benefícios a saúde e por suas propriedades antioxidantes que podem ser maiores que o das infusões não fermentadas. A kombucha também apresenta atividade antibacteriana contra bactérias Gram-positivas e Gram-negativas patogênicas, sendo o principal componente antibacteriano, o ácido acético. Assim, objetivo desta revisão integrativa é analisar a produção cientifica sobre as propriedades antioxidantes e os efeitos antimicrobianos de kombuchas. A revisão integrativa foi baseada em etapas sistemáticas, nas bases de dados Scopus e ScienceDirect. As buscas seguiram os critérios de inclusão: estudos que abordaram as propriedades antioxidantes e antimicrobiana da kombucha, disponíveis na integra nos idiomas inglês, português e espanhol, sem período de publicação delimitado. Excluídos: teses, dissertações, revisões (sistemática, narrativa e integrativa), artigos de opinião e editoriais. Foram incluídos 18 artigos, 7 artigos analisaram a atividade antibacteriana e observaram que as kombuchas apresentam efeitos maiores que as infusões não fermentadas. A maioria dos artigos determinaram a atividade antioxidante de kombuchas de diferentes substratos, principalmente do chá verde e do chá preto. Todos os artigos mostraram aumento da atividade antioxidante das kombuchas ao longo da fermentação. Assim, a kombucha pode ser uma alternativa saudável para a manutenção dos níveis de radicais livres e no combate de micro-organismos patogênicos para quem a consome.
Neuroprotective effect of Lithospermum officinale callus extract on inflamed primary microglial cells
Authors: Kheyrollah Maryam , Sabouni Farzaneh , Farhadpour Mohsen , Haghbeen Kamahldin 
Published: November 2020

Background and Objective:
Lithospermum officinale is a famous medicinal herb in the traditional medicine of
India. However, the medicinal use of its root extract is limited due to the presence of pyrrolizidine alkaloids (PzAl). It was
recently shown that PzAl are not accumulated in the cell culture of L. officinale while the biosynthetic pathway of phenolic
acids remains active so that rosmarinic acid (RsA) is the main product in the proliferated callus. Considering the existing literature on the anti-inflammatory effects of caffeic acid (CfA) and its derivatives, this research was devoted to the evaluation
of the anti-inflammatory capacity of methanolic extracts of L. officinale callus (LoE) on the rat microglial cells as the immune cells of the Central Nervous System, which play an essential role in the responses to neuroinflammation.

Methods:
primary microglia were obtained from Wistar rat, then they were subjected to various amounts of CfA and methanolic extracts of 17 and 31-day L. officinale callus prior to stimulation by LPS. In addition to HPLC analysis of the extracts, viability, nitric oxide production, evaluation of the pro-inflammatory genes and cytokines in the inflamed microglia
were investigated.

Results:
Methanolic extract of the 17-day old callus of L. officinale exhibited anti-inflammatory effects on the LPS- stimulated microglial cells much higher than that was observed for CfA. The data was further supported by the decreased expression of NOS2, TNF-α, and Cox-2 mRNA and the suppression of TNF-α and IL-1β release in the activated microglial cells
pretreated with the effective dose of LoE (0.8 mg mL-1).

Conclusion:
It was assumed that better anti-neuroinflammatory performance of LoE than CfA in LPS-activated primary microglia could be a result of synergism of the components of the extract and the lipophilic nature of RsA as the main phenolic
acid of LoE. Considering the fact that LoE shows high antioxidant capacity and lacks PzAl, it is anticipated that LoE is considered as a reliable substitute to the extract of the natural root of L. officinale and plays a key role in the preparation of neuroprotective pharmaceutical formula.
A Comprehensive Study of Pharmacological Behaviors, Nano-Formulations, and Applications of Rosemary
Authors: Khatoon Rizwana , Alam Md. Aftab , Sharma Pramod Kumar 
Published: November 2020

Aim:
The purpose of this review paper is to elaborate many nano-formulations of Rosemary
which are used against many diseases and also explain the Pharmacological activity of phytocompounds
of Rosemary and detail about the applications and uses of Rosemary in many fields.

Objectives:
Rosemary (Rosmarinus officinalis L.) is a medicinal herbal plant; their leaves are used
in Europe, America, and Asia as a food additive. It is very valuable; its parts contain many chemical
constituents which are very effective against many diseases like diabetes, obesity, cancer, infections
and also have antioxidant, anti-inflammation, memory-improvement, etc. properties.

Results:
In the literature reviewed, Rosmarinus officinalis (rosemary) has shown exciting potential
both as a natural food preservative and therapeutic agent. Rosemary (Rosmarinus officinalis) essential
oil has been extensively studied due to its chemical composition and biological activities. The
extract of Rosemary also shows medicinal properties like anticancer, antimicrobial, antidiabetic, anti-
inflammatory, etc. From many studies, it was also found that nano-formulation of Rosemary had
been developed by using the Rosemary essential oil and its extract used in the diagnosis and treatment
of many diseases.

Conclusion:
From the conventional times, therapeutic effects of Rosemary are seen, which is also
used in Modern Medicine nowadays. It had been used as food additives in conventional times. In renal
colic and dysmenorrhea, it is used as an antispasmodic to relieve respiratory disorders and to
boost hair development. CNS, cardiac and locomotive activity promote inhalation and oral administration
of Rosemary oil, suggesting the direct effect of one or more of its constituents. Rosemary
has curative potential in the therapy and avoidance of bronchial asthma, peptic ulcer, spasmodic disorders,
inflammatory illnesses, atherosclerosis, hepatotoxicity, cancer, ischemic heart illness, bad
sperm motility, Alzheimer, and may act as an antidepressant and anxiolytic properties.
Neurotoxic Mechanism and Shortcomings of MPTP, 6-OHDA, Rotenone and Paraquat-induced Parkinson’s Disease Animal Models
Authors: Okyere Samuel Kumi , Zeng Chaorong , Yue Dong , Hu Yanchun 
Published: November 2020

:
Parkinson’s disease (PD) has caused most economies to lose their active human capital.
Due to poor understanding of the pathophysiology of PD, PD animal models were developed to aid
the investigation of PD pathogenesis and therapy. Currently, the toxin-induced and the genetic animal
models are being used for most PD research.
Most neurotoxin animal model studies on PD are focused on the motor features and economic importance
associated with dopamine depletion; however, the molecular pathways for cell loss by
these models and its usefulness in PD drug development have not been reported fully. In this review,
we have provided a summary of the toxic mechanism and shortcomings of four neurotoxins (6-OHDA,
MPTP, Rotenone and, Paraquat) that are frequently used to mimic PD in animal models. This review
will give readers basic knowledge for selecting the best toxin for a specific PD experiment and
also provide information that will help in the future development of toxins with fewer shortcomings.
This review also summarizes the mechanism and features of some PD genetic models.