bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of quitting water pipe during pregnancy on Anthropometric measurements at birth: a population-based prospective cohort study in South of Iran
Authors: Nematollahi Shahrzad , Holakouie-Naieni Koroush , Madani Abdolhossain , Shabkhiz Hossein , Torabi Elham , Lotfi Samaneh 
Published: December 2019

Abstract
Background: Evidence on health effects of tobacco cessation in pregnancy is mainly restricted to cigarette, while water pipe smoking is more prevalent among women in the Middle-East. The present ‎study aimed to assess the effects of cessation of water pipe during pregnancy on ‎birth anthropometric measures in South of Iran. Methods: Data on 1,120 singleton pregnancies (response rate=93.4%) from a population-based prospective cohort study in suburban communities in Bandar Abbas city was used. Birth measures were used according to infant`s vaccination cards. Study subjects were categorized into three subgroups based on water pipe ‎smoking status during pregnancy, including: 1) mothers who never smoke water pipe ‎‎(never smoker); 2)mothers who stopped water pipe during pregnancy and resumed it postpartum (quitters); 3) mothers who continued smoking water pipe regardless ‎of their pregnancy (always smokers). ‎Generalized Linear Models (GLMs) were utilized for the analyses. Results: Compared to never smokers, quitting water pipe in pregnancy would decrease mean birthweight by 99.30 ‎grams (β:-99.30, 95%CI:-204.35,-5.75‎); while an additional decrease by 37.83 grams would occur in always smokers (β:-137.13‎;95%CI:-262.21,-‎‎12.05‎). Mean birth length ‎did not significantly differ among the three water pipe groups. Mean head ‎circumference, however, would significantly increase by 0.79 centimeter in always smokers (β:079,95%CI:0.13,1.45). ‎ Conclusions: Quitting water pipe during pregnancy had positive effects on infant growth, especially birth weight. Some suggestions are provided including integration of information on health benefits of quitting smoking into routine prenatal healthcare services and development of awareness programs to encourage smokers to quit early in pregnancy.
Outcomes of a retrospective study on sustained release betamethasone for transient radicular symptoms in patients after Transforaminal Lumbar Interbody Fusion operation
Authors: Li Haojie , Wang Yang , Ma Weihu , Xv Dingli 
Published: December 2019

Abstract
Objective To observe the efficacy and Complications of gelatin sponge sustained release betamethasone for transient radicular symptoms in patients after TLIF operation.Method A total of 218 patients with single-level LDH were retrospectively analyzed from March 2017 to July 2019. Patients were divided into observation group and control groups according to different approach.Clinical data such as lasegue sign, VAS score, ODI index were compared, the data analyzed by SPSS 24.0 statistical software.Results 186 patients were finally included. The observation group has significantly different between the control groups(P<0.05)at five days after surgery. And there was no significant difference in VAS and ODI between the four groups (P > 0.05)at 2-3 months after surgery, . There was no significant difference in blood glucose before and after operation in the observation group(P > 0.05), and numeration of leukocyte in the four groups was significantly higher than before operation (P<0.05), but there was no statistically significant difference between the four groups before and after operation (P > 0.05). The patients in the four groups had basically the same satisfaction with the final efficacy (> 90%) . In addition, there was the same Complications in four groups(eg.postoperative nausea, vomiting and other complications.)Conclusion the use of gelatin sponge sustained-release steroids and other mixed solutions can significantly relieve transient radicular symptoms after TLIF operation,and does not influence the occurrence of postoperative complications.
Effect of magnet position on tipping and bodily tooth movement in magnetic force-driven orthodontics
Authors: Ishida Yoshiki , Kuwajima Yukinori , Lee Cliff , Ogawa Kaho , Silva John Daren Da , Ishikawa-Nagai Shigemi 
Published: December 2019

Abstract
Magnets have many advantages for orthodontic applications. The purpose of this study was to investigate the effect of the magnet position on the tipping and bodily tooth movement using 3D digital analysis ex vivo. Orthodontic typodont models for space-closing (2mm diastema) were created, mimicking maxillary central incisors. Tooth models (10mm crown and 14mm root length) created by 3D printer were used for the typodont model. Nd-Fe-B magnets were placed in the middle of the tooth (Model-M) and the cervical area (Model-C). The typodonts were immersed in a hot water-bath at 55℃ to initiate tooth movement. The scanned typodont data before and after tooth movement were superimposed, and 3D coordinates (X, Y, Z) on the tooth were obtained. The root apex data was also obtained by superimposing the designed tooth model on the crown portion of the typodont model. 3D movement of the crown and the root apex, moving speed, degree of rotation (yaw, pitch, and roll) in 2 models were analyzed and compared by Pearson’s correlation confidents. Moderate crowding typodont cases were treated with two magnet position settings, and patterns of tooth/root movement and rotation were compared. The largest movement was observed in the X-axis as intended. Model-M indicated higher moving speed and more tooth rotation than Model-C. In Model-M, the root apex moved to the opposite direction of the crown movement with a negative correlation. In contrast, the crown and root apex moved in the same direction with a positive correlation in Model-C. In the ex vivo moderate crowding case, Model-C created bodily movement, in which the cusp and root apex both moved in the same direction with less tooth rotation. The results of this study validated that modifying the position of the applied magnetic force was able to increase the amount of bodily tooth movement and decrease unwanted rotation/tipping in an ex vivo setting.
Higher toenail selenium is associated with increased insulin resistance risk in omnivores, but not in vegetarians
Authors: Gu Qiuyun , Cui Xueying , Du Kun , Wang Bian , Cai Wei , Tang Qingya , Shen Xiuhua 
Published: December 2019

Abstract
Background The relationship between selenium (Se) and insulin resistance remains unclear. We aim to evaluate the association between toenail Se levels and insulin resistance in China.Methods In this cross-sectional study, 220 vegetarians and 220 age-sex- matched omnivores from Shanghai were included. The toenail Se levels were measured by inductively coupled plasma mass spectrometry method. Dietary Se intakes were assessed by the 24-hour dietary recall questionnaire. Blood samples were collected to examine fasting blood glucose and fasting insulin concentrations. Insulin resistance index (HOMA-IR) and insulin secretion index (HOMA-B) were calculated to assess insulin resistance. The multilinear regression models were performed, and the following covariates were included in the models: age, sex, BMI, alcohol consumption, income, and daily dietary intakes (energy, protein, fat, carbohydrate, and fiber).Results Toenail Se levels were not associated with insulin resistance among vegetarians but were positively associated with fasting insulin levels (β=1.030, 95% CI: 0.393, 1.667) and HOMA-IR (β=0.245, 95% CI: 0.098, 0.392) in omnivores. Stratifying the results by Se intake levels in the omnivores revealed a significant association among those with dietary Se intake ≥ 60 μg/d; insulin level (β=1.053, 95% CI: 0.415, 1.691) and HOMA-IR (β=13.271, 95% CI: 4.433, 22.109) but not in those with < 60 μg/d ; insulin level (β=2.146, 95% CI: -0.710, 5.002) and HOMA-IR (β=13.766, 95% CI: -46.868, 74.400).Conclusions Higher toenail Se levels were associated with increased insulin resistance risk in Chinese omnivores, but not in vegetarians.
MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human ovarian granulosa cells by targeting FGD4
Authors: Lin Ji , Huang Huijuan , Lin Liheng , Li Weiwei , Huang Jianfen 
Published: December 2019

Abstract
Background: MiRNAs play important roles in the development of ovarian cancer, activation of primitive follicles, follicular development, oocyte maturation and ovulation. In the present study, we investigated the specific role of miR-23a in human ovarian granulosa cells. Results: Downregulation of miR-23a was observed in in serum of PCOS patients compared with the healthy control, suggesting the inhibitory effect of miR-23a in PCOS. MiR-23a was positively correlated with Body Mass Index (BMI) and negatively correlated with Luteinizing hormone (LH) of PCOS patients. MiR-23a mimic inhibited the proliferation and promoted apoptosis of human ovarian granulosa cells. In addition, flow cytometry assay confirmed that miR-23a blocked cell cycle on G0/G1 phase. MiR-23a inhibitor showed opposite results. Furthermore, double luciferase reporter assay proved that miR-23a could bind to the 3’UTR of FGD4 directly through sites predicted on Target Scan. FGD4 level was significantly suppressed by miR-23a mimic, but was significantly enhanced by miR-23a inhibitor. We further proved that miR-23a increased the expression of activated CDC42 (GTP bround) and p-PAK-1, suggesting that miR-23a induced cell cycle arrest through CDC42/PAK1 pathway. Conclusions: In conclusion, our study reveals that miR-23a participates in the regulation of proliferation and apoptosis of ovarian granulosa cells through target FGD4, which may have potential for clinical diagnosis and treatment of PCOS patients.
LncGBP9/miR-34a axis modulates macrophage M1/M2 polarization to affect spinal cord injury repair via STAT1/STAT6 and SOCS3
Authors: Zhou Jiahui , Li Zhiyue , Wu Tianding , Zhao Qun , Zhao Qiancheng , Cao Yong 
Published: December 2019

Abstract
Background: Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The dysregulation of macrophage polarization to a pro-inflammatory (M1) or an anti-inflammatory phenotype (M2) might cause the failure to post-SCI repair.Methods: In the present study, we conducted SCI model in Balb/c mice and observed the deregulation of M1/2 macrophage polarization after SCI; by bioinformative analyses, lncRNA lncGBP9 and SOCS3 have been regarded as potent regulators of the macrophage polarization after SCI. Mouse bone marrow-derived macrophages (BMDMs) were isolated and identified.Results: In M1 macrophages, lncGBP9 silence significantly decreased p-STAT1 and SOCS3 expression and protein levels, as well as the production of IL-6 and IL-12; in M2 macrophages, lncGBP9 overexpression increased SOCS3 expression and protein levels while suppressed p-STAT6 levels and the production of IL-10 and TGF-β1, indicating that lncGBP9 overexpression promotes the M1 polarization of macrophages. In lncGBP9-silenced SCI mice, the M2 polarization was promoted on day 28 after operation, further indicating that lncGBP9 silence revised the predominance of M1 polarization at the late stage of secondary injury after SCI, therefore improving the repair after SCI. Conclusions: In macrophages, lncGBP9 sponges miR-34a to rescue SOCS3 expression, therefore modulating macrophage polarization.
The antibacterial properties and mechanism of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles
Authors: Leng Diya , Li Yan , Zhu Jie , Liang Ruizhen , Zhang Cuifeng , Zhou Yang , Li Mingming , Wang Ying , Rong Di , Wu Daming , Li Jin 
Published: December 2019

Abstract
Background: Silver (Ag) and/or zinc (Zn) incorporated mesoporous calcium-silicate nanoparticles (MCSNs) have good physicochemical characteristics and can be advanced materials for root canal filling. This study was to analyze the antibacterial properties and mechanism of Ag/Zn-MCSNs with different percentage of Ag and Zn.Methods: The antibacterial properties and the cytotoxicity of them were evaluated. Human root canals were inoculated with E. faecalis for 4 weeks to establish bacterial biofilm model. The E. faecalis biofilms were treated with MCSNs, Ag-MCSNs, Zn-MCSNs, Ag/Zn-MCSNs, calcium hydroxide (CH) and mineral trioxide aggregate (MTA) for 7 days. The ultrastructure and distribution of viable bacteria of the specimens were evaluated using SEM and CLSM. Human root canals were pretreated with CH, MCSNs, Ag-MCSNs, Zn-MCSNs and Ag/Zn-MCSNs, then the root canals were immersed in E. faecalis suspension for 7 days. The adhesion and colonization of E. faecalis on the root canal walls were observed using SEM and CLSM. Endocytosis of E. Faecalis treated by Ag-MCSNs and Ag/Zn-MCSNs were observed using TEM. Results: The MCSNs containing Ag showed better antibacterial properties than MCSNs and Zn-MCSNs (P<0.05). MCSNs, Ag/Zn(1:1)-MCSNs and Ag/Zn(1:9)-MCSNs showed no obvious cytotoxicity (P>0.05), while Ag-MCSNs and Ag/Zn(9:1)-MCSNs showed cytostatic effects. Zn-MCSNs slightly promote cell proliferation (P<0.05). The MCSNs containing Ag showed antibacterial abilities against E. faecalis biofilm in different degree, and can adhere to dentin surfaces to get a continuous antibacterial effect, but MTA, MCSNs and Zn-MCSNs could not disrupt the bacterial biofilm obviously. The Ag-MCSNs and Ag/Zn-MCSNs release Ag+ and destroy the cell membranes to kill bacteria. Conclusions: The antibacterial effects and cytotoxicity of Ag/Zn-MCSNs are related to Ag content, while Zn reduce cytotoxicity and promote cell proliferation.
Evaluation of TaqMan Array Card (TAC) for the Detection of 28 Respiratory Pathogens
Authors: Liu Keke , Jing Hongbo , Chen Ying , Zheng Xin , Jiang Hua , Kong Decong , Zheng Yvling , Chen Shuiping , Liu Peng , Jiang Yongqiang 
Published: December 2019

AbstractBackground: Respiratory infections are a serious threat to human health. So, rapid detection of all respiratory pathogens can facilitate prompt treatment and prevent the deterioration of respiratory disease. Previously published primers and probes of the TaqMan array card (TAC) for respiratory pathogens are not sensitive to Chinese clinical specimens. This study aimed to develop and improve the TAC assay to detect 28 respiratory viral and bacterial pathogens in a Chinese population. Methods: To improve the sensitivity, we redesigned the primers and probes, and labeled the probes with minor groove binders. The amplification efficiency, sensitivity, and specificity of the primers and probes were determined using target-gene containing standard plasmids. The detection performance of the TAC was evaluated on 754 clinical specimens and the results were compared with those from conventional methods. Results: The performance of the TAC assay was evaluated using 754 clinical throat swab samples and the results were compared with those from gold-standard methods. The sensitivity and specificity were 95.4% and 96.6%, respectively. The lowest detection limit of the TAC was 10 to 100 copies/μL. Conclusions: TAC is an efficient, accurate, and high-throughput approach to detecting multiple respiratory pathogens simultaneously and is a promising tool for the identification of pathogen outbreaks.
MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis
Authors: Huang Tao , Zhang Jun , Ke Wujian , Zhang Xiaohui , Chen Wentao , Yang Jieyi , Liao Yiwen , Liang Fangwen , Mei Shuqing , Li Mingjiu , Luo Zhenzhou , Zhang Qiwei , Yang Bin , Zheng Heping 
Published: December 2019

Abstract
Background
Treponema pallidum ( T. pallidum ) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have been shown to influence immune cell function and, consequently, the generation of antibody responses during other microbe infections. However, these mechanisms are unknown for T. pallidum .
Methods
In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy individuals, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. miRNAs were profiled from the peripheral blood of patients obtained at the time of serological diagnosis. Then, both the target sequence analysis of these different miRNAs and pathway analysis were performed to identify important immune and cell signaling pathways. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for microRNA analysis.
Results
A total of 89 differentially regulated miRNAs were identified. Following RT-qPCR confirmation, three miRNAs (hsa-miR-195-5p, hsa-miR-223-3p, hsa-miR-589-3p) showed significant differences in the serofast and serologically cured states ( P <0.05). One miRNA (hsa-miR-195-5p) showed significant differences between untreated patients and healthy individuals.
Conclusions
This is the first study of miRNA expression differences in peripheral blood mononuclear cells (PBMCs) in different stages of T. pallium infection. Our study suggests that the combination of three miRNAs has great potential to serve as a non-invasive biomarker of T. pallium infections, which will facilitate better diagnosis and treatment of T. pallium infections.
Architectural Education for Sustainable Urban Regeneration
Authors: Çahantimur Arzu , Öztürk Rengin Beceren 
Published: December 2019

Urban regeneration is one of the important agendas of Turkey as a developing country. Rapid urbanization problems have been causing vital social and economic problems together with physical and spatial ones especially in big cities of Turkey. Thus, national and local governments handled urban regeneration as a practical method for solution of these problems. However, they unfortunately don’t implement urban regeneration according to its real requirements. Instead, this multi-dimensional and complex process is seen as a pull down and built up operation. Considering this situation and being in awareness of the responsibilities of architects throughout urban regeneration process, the authors think that urban regeneration should be discussed in the scope of architectural education. This paper presents the purpose, the process and the products of an undergraduate architectural design studio that was undertaken at Bursa Uludağ University, Faculty of Architecture. The architectural and urban design projects of the students of which aim was to offer a livable and sustainable mixed used living environments are discussed together with their conceptual backgrounds. Putting stress on the differences between theory and practice, the conclusion introduces a critical evaluation of urban regeneration and sustainable housing concepts in Turkey.
Using C. vulgaris assisted microbial desalination cell as a green technology in landfill leachate pre-treatment: a factor-performance relation study
Authors: Hui Wang Jian , David Ewusi-Mensah , Huang Jingyu 
Published: December 2019

Abstract
Algae biocathodes have become one of the most sustainable replacements for abiotic cathodes which were expensive and had toxic chemical oxidant by-products. In this study, a pure culture of Chlorella vulgaris from a photobioreactor was pumped into a photosynthetic microbial desalination cell to treat real landfill leachate (had undergone physical treatment) under varying ‘factor-conditions (FC)’ to embark on a factor-performance relation (FPR) study. This aimed at determining the relationship between operating factors and to depict the most favourable conditions (and range) in order to boost the overall performance of the reactor/cell. Three groups of FC (A, B and C) were adapted, in that, under FC A external resistance was varied, FC B varied pumping rate and FC C varied temperature, light intensity and dissolved oxygen under conditions flow and recirculation mode. Results showed 95% chemical oxygen demand (COD) removal, a maximum power density of 121.57 mWm−2 (anodic volume) and an average desalination rate of 3.93 mg/L/h. The varying results at different FC showed the significant impact of operating conditions on performance. Algae biocathodes also proved to be an essential benefit in boosting the sustainable application of microbial desalination cells (MDCs) in wastewater and landfill pre-treatment as well as the generation of bioenergy.
As(III) removal by Fe(III)-amidoximated PAN in the presence of H2O2 through simultaneous oxidation and adsorption
Authors: Gao Luyao , Hao Mengna , Bu Fanling , Ji Chunnuan , Qu Rongjun , Sun Changmei , Zhang Ying 
Published: December 2019

Abstract
This study explored the efficient removal of As(III) by Fe(III)-amidoximated PAN (Fe(III) AO PAN) in the presence of H2O2 through simultaneous oxidation and adsorption. It presented that As(III) could be oxidized to As(V) efficiently in the pH range 3–9 within a short time. At the same time, the oxidized As(V) was adsorbed by Fe(III)-AO PAN. The effect of pH value, H2O2 concentration, Fe(III)-AO PAN amount, and coexisting anions on the As(III) oxidation and removal were investigated in detail. Dynamic adsorption on fixed column was also studied. Arsenic removal efficiency including As(III) and As(V) could be achieved (95.2%) by the simultaneous oxidation and adsorption process at the following optimal conditions: pH = 6.5, dosage of Fe(III)-AO PAN = 2.5 g/L, H2O2 = 100 mg/L, initial concentration of As(III) = 5 mg/L. Dynamic adsorption on fixed column demonstrated that As(III) in simulated groundwater could be efficiently removed from 500μg/L to &lt;10 μg/L within 130 bed volumes (BV).
Kinetics studies on the adsorption of Methyl Orange and Metanil Yellow onto bottom ash: a comparative account
Authors: Malviya Arti , Jaspal Dipika Kaur , Khamparia Shraddha 
Published: December 2019

AbstractThe focal point of the study lies in the comparative evaluation of the kinetic data involved in the eradication of toxic dyes from waste waters using the adsorption technique. The investigation reveals the dynamic adsorption behavior of two hazardous textile dyes viz. Metanil Yellow and Methyl Orange over bottom ash, an industrial waste material. The impact of several experimental parameters has been inspected using batch mode to acquire information on the ongoing mechanism. The graphical profiles obtained for the adsorption of Metanil Yellow and Methyl Orange onto bottom ash suggested an increase in the adsorption rate with time, with gradual attainment of equilibrium between the adsorbing species and adsorbent. The study revealed that second-order kinetics has been followed in both cases. Adsorption of Methyl Orange over bottom ash followed particle diffusion whereas film diffusion predominated in the case of Metanil Yellow.