bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages
Authors: He Shaoqi , Ruan Dengfeng , Chen Yangwu , Ran Jisheng , Chen Xiao , Yin Zi , Tang Chenqi , Huang Jiayun , Heng Boon Chin , Chen Jialin , Chen Weishan , Shen Weiliang , Ouyang Hongwei 
Published: October 2019

AbstractMeniscus-derived stem cells (MeSCs) are a potential cell source for meniscus tissue engineering. The stark morphological and structural changes of meniscus tissue during development indicate the complexity of MeSCs at different tissue regions and stages of development. In this study, we characterized and compared postnatal rat meniscus tissue and MeSCs at different tissue regions and stages of development. We observed that the rat meniscus tissue exhibited marked changes in tissue morphology during development, with day 7 being the most representative time point of different developmental stages. All rat MeSCs displayed typical stem cell characteristics. Rat MeSCs derived from day 7 inner meniscus tissue exhibited the highest self-renewal capacity, cell proliferation, differentiation potential toward various mesenchymal lineage and the highest expression levels of chondrogenic genes and proteins. Transplantation of rat MeSCs derived from day 7 inner meniscus tissue promoted neo-tissue formation and effectively protected joint surface cartilage in vivo. Our results demonstrated for the first time that rat MeSCs are not necessarily better at earlier developmental stages, and that rat MeSCs derived from day 7 inner meniscus tissue may be a superior cell source for effective meniscus regeneration and articular cartilage protection. This information could make a significant contribution to human meniscus tissue engineering in the future. Stem Cells Translational Medicine 2019;8:1318&1329
Preparation of Organic‐Free Two‐Dimensional Kaolinite Nanosheets by In Situ Interlayer Fenton Reaction
Authors: Liu Tong , Qu Hao , Tian Jiaxin , He Sihui , Su Yue , Su Haiquan 
Published: October 2019

AbstractA novel and facile approach to prepare exfoliated two‐dimensional (2D) kaolinite is reported in this study. The exfoliation was performed through a reaction of kaolinite‐dimethylsulfoxide intercalation compound with hydrogen peroxide (H2O2). The characterizations indicated that the reaction was an interlayer in‐situ Fenton reaction where Fe2+ in kaolinite plays a key role and the produced gas is the driven force of kaolinite exfoliation. It is important that the obtained nanosheets were only about 2 nm thick and there were no residual organic compounds on their surface, which was critical for certain practical applications. In addition, the exfoliated kaolinite showed an enhanced Pb (II) adsorption performance in a wide pH range of 2.5‐6.5 compared with the original kaolinite.
Pyridyl Azo‐Based Progelator in Selective Sensing of Hg2+ and Ag+ Ions via Sol to Gel Conversion
Authors: Raza Rameez , Dey Nilakshi , Panja Atanu , Ghosh Kumaresh 
Published: October 2019

AbstractA pyridyl azo‐based progelator 1 has been designed and synthesized for selective detection of Hg2+ and Ag+ ions in sol‐gel media. Compound 1 acts as nongelator in DMSO‐H2O (1:1, v/v) while its aldehyde‐counterpart 3 forms stable gel under identical conditions. The specific Hg2+‐induced deprotection of the thioacetal functionality in 1 results in in‐situ formation of the precursor aldehyde 3 and thereby induces sol‐to‐gel transformation in DMSO‐H2O (1:1, v/v). Gelation is also observed in the presence of Ag+ ion. Interestingly, the gelation modes of 1 in the presence of Hg2+ and Ag+ ions are different. The Hg2+‐induced gelation involves dosimetric sensing while the Ag+‐induced gelation involves simple metal‐ligand non‐covalent interaction, as established by using different chelating agents and spectroscopic techniques. The design of metal‐responsive low molecular weight gelators (LMWGs) involving protection/deprotection of functional groups in gelator structure is rarely investigated in the literature and hence draws attention.
Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry
Authors: Yang Lin , Gradl Regine , Dierolf Martin , Möller Winfried , Kutschke David , Feuchtinger Annette , Hehn Lorenz , Donnelley Martin , Günther Benedikt , Achterhold Klaus , Walch Axel , Stoeger Tobias , Razansky Daniel , Pfeiffer Franz , Morgan Kaye S. , Schmid Otmar 
Published: October 2019

AbstractTargeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. This study introduces a preclinical imaging platform combining X‐ray (two modes) and fluorescence imaging (three modes) techniques for time‐resolved in vivo and spatially resolved ex vivo visualization of mouse lungs during pulmonary NP delivery. Liquid mixtures of iodine (contrast agent for X‐ray) and/or (nano)particles (X‐ray absorbing and/or fluorescent) are delivered to different regions of the lung via intratracheal instillation, nasal aspiration, and ventilator‐assisted aerosol inhalation. It is demonstrated that in vivo propagation‐based phase‐contrast X‐ray imaging elucidates the dynamic process of pulmonary NP delivery, while ex vivo fluorescence imaging (e.g., tissue‐cleared light sheet fluorescence microscopy) reveals the quantitative 3D drug/particle distribution throughout the entire lung with cellular resolution. The novel and complementary information from this imaging platform unveils the dynamics and mechanisms of pulmonary NM/NP delivery and deposition for each of the delivery routes, which provides guidance on optimizing pulmonary delivery techniques and novel‐designed NM for targeting and efficacy.
Peptide Nanotube‐Templated Biomineralization of Cu2−xS Nanoparticles for Combination Treatment of Metastatic Tumor
Authors: Lai Yi , Xu Zhiai , Hu Xianli , Lei Li , Li Lingling , Dong Liang , Yu Haijun , Zhang Wen 
Published: October 2019

Abstract1D peptide nanostructures (i.e., peptide nanotubes, PNTs) exhibit tunable chemo‐physical properties and functions such as improved tissue adhesion, increased cellular uptake, and elongated blood circulation. In this study, the application of PNTs as a desirable 1D template for biomineralization of Cu2−xS nanoparticles (Cu2−xS NPs, x = 1–2) is reported. Monodisperse Cu2−xS NPs are uniformly coated on the peptide nanotubes owing to the specific high binding affinity of Cu ions to the imidazole groups exposed on the surface of nanotubes. The Cu2−xS NP–coated PNTs are further covalently grafted with an oxaliplatin prodrug (Pt–CuS–PNTs) to construct a versatile nanoplatform for combination cancer therapy. Upon 808 nm laser illumination, the nanoplatform induces significant hyperthermia effect and elicits reactive oxygen species generation through electron transfer and Fenton‐like reaction. It is demonstrated that the versatile nanoplatform dramatically inhibits tumor growth and lung metastasis of melanoma in a B16‐F10 melanoma tumor‐bearing mouse model by combined photo‐ and chemotherapy. This study highlights the ability of PNTs for biomineralization of metal ions and the promising potential of such nanoplatforms for cancer treatment.
In‐Plane Potential Gradient Induces Low Frictional Energy Dissipation during the Stick‐Slip Sliding on the Surfaces of 2D Materials
Authors: He Feng , Yang Xiao , Bian Zhengliang , Xie Guoxin , Guo Dan , Luo Jianbin 
Published: October 2019

AbstractUnderstanding the nanoscale friction properties of 2D materials and further manipulating their friction behaviors is of great significance for the development of various micro/nanodevices. Recent studies, taking advantage of the close relationship between friction and surface charges, use an external out‐of‐plane electric field to control the interfacial friction. Nevertheless, friction increases with the application of the out‐of‐plane electric field in most cases. Here, an in‐plane potential gradient is applied for the investigation of the contribution of electric charges to friction on the surfaces of 2D materials. Experimental results show that the friction between an atomic force microscope tip and the flakes of 2D materials decreases with the application of the in‐plane potential gradient, and the higher the potential gradient, the greater the friction decrease. By comparing the in situ atomic‐level stick‐slip maps before and after the application of the in‐plane potential gradient, it is proposed that the promotion of low friction dissipative motion during the stick‐slip process owing to the presence of the potential gradient gives rise to the friction reduction. These results not only help to reveal the origin of friction, but also provide a novel way to manipulate friction through an electrically‐controlled sliding process.
Nonconfinement Structure Revealed in Dion–Jacobson Type Quasi‐2D Perovskite Expedites Interlayer Charge Transport
Authors: Yu Shuang , Yan Yajie , Abdellah Mohamed , Pullerits Tõnu , Zheng Kaibo , Liang Ziqi 
Published: October 2019

AbstractDion–Jacobson (DJ) type 2D perovskites with a single organic cation layer exhibit a narrower distance between two adjacent inorganic layers compared to the corresponding Ruddlesden–Popper perovskites, which facilitates interlayer charge transport. However, the internal crystal structures in 2D DJ perovskites remain elusive. Herein, in a p‐xylylenediamine (PDMA)‐based DJ perovskite bearing bifunctional NH3+ spacer, the compression from confinement structure (inorganic layer number, n = 1, 2) to nonconfinement structure (n > 3) with the decrease of PDMA molar ratio is unraveled. Remarkably, the nonconfined perovskite displays shorter spacing between 2D quantum wells, which results in a lower exciton binding energy and hence promotes exciton dissociation. The significantly diminishing quantum confinement promotes interlayer charge transport leading to a maximum photovoltaic efficiency of ≈11%. Additionally, the tighter interlayer packing arising from the squeezing of inorganic octahedra gives rise to enhanced ambient stability.
TraceChain: A blockchain‐based scheme to protect data confidentiality and traceability
Authors: Fan Yongkai , Lin Xiaodong , Liang Wei , Wang Jinghan , Tan Gang , Lei Xia , Jing Lei 
Published: October 2019

SummaryThe risk of sharing data in cloud computing has gathered increasing attention. After the owner of some confidential data outsources the data to cloud storage services and shares it with others, the data owner lost the control to the data to a large extent. To achieve data sharing while keeping data confidentiality, attribute‐based encryption (ABE) can be employed by cloud storage services. However, ABE can only guarantee that outsourced data on the cloud is decrypted by attribute‐satisfying users but cannot restrict data from being accessed by dishonest users whose attributes also satisfy the access‐control policy. It is impossible for the data owner to control the shared data after it has been decrypted by dishonest users, especially when a set of attribute‐satisfying dishonest users may collude. To address this concern, we propose a traceable data sharing scheme called TraceChain. In TraceChain, data is encrypted over a new CP‐ABE scheme called E‐CP‐ABE. Furthermore, the system parameters for generating the private key in E‐CP‐ABE are uploaded to the private blockchain and transactions are performed on the chain. The data owner can obtain the identity of users by monitoring system parameters simultaneously and control data sharing on the blockchain. To prove the security of our scheme, the security analysis is given in this paper. Meanwhile, experimental results also show that our system is viable and efficient.
CloudSimSDN‐NFV: Modeling and simulation of network function virtualization and service function chaining in edge computing environments
Authors: Son Jungmin , He TianZhang , Buyya Rajkumar 
Published: October 2019

SummarySoftware‐defined networking (SDN) has evolved and brought an innovative paradigm shift in computer networks by utilizing a programmable software controller with open protocols. Network functions, previously served on dedicated hardware, have shifted to network function virtualization (NFV) that enabled functions to be virtualized and provisioned dynamically upon generic hardware. In addition to NFV, edge computing utilizes the edge resources close to end‐users, which can reduce the end‐to‐end service delay and the network traffic volume. Although these innovative technologies gained significant attention from both academia and industry, there are limited tools and simulation frameworks for the effectiveness evaluation in a repeatable and controllable manner. Furthermore, large‐scale experimental infrastructures are expensive to setup and difficult to maintain. Even if they are created, they are not available or accessible for the majority of researchers throughout the world. In this paper, we propose a framework for simulating NFV functionalities in both edge and cloud computing environments. In addition to the basic network functionalities supported by SDN in CloudSimSDN, we added new NFV features, such as virtualized network functions allocation, migration, and autoscaling with the support of corresponding network functionalities, such as flow load balancing, rerouting, and service function chaining (SFC) maintenance. We evaluated our simulation framework with autoscaling and placement policies for SFC in the integrated edge and cloud computing environments. The results demonstrate its effectiveness in measuring and evaluating the end‐to‐end delay, response time, resource utilization, network traffic, and power consumption with different algorithms in each scenario.
ADARC: An anomaly detection algorithm based on relative outlier distance and biseries correlation
Authors: Ji Cun , Zou Xiunan , Liu Shijun , Pan Li 
Published: October 2019

SummaryThe application of anomaly detection to data monitoring is a fundamental requirement of the public service systems of a smart city. Many detection methods have been proposed for identifying anomalous situations, including methods based on periodicity or biseries correlations. However, the detection results of these methods are not ideal. Thus, we present a new anomaly detection algorithm for time series based on the relative outlier distance (ROD) and biseries correlations. The proposed algorithm detects outliers based on the ROD and identifies abnormal points and change points based on biseries correlations. Experimental results show that our method achieves better recall and F1‐measure scores than various time series–based techniques while maintaining a high level of precision.
Tuning the Photophysical Properties of Push‐Pull Azaheterocyclic Chromophores by Protonation: A Brief Overview of a French‐Spanish‐Czech Project
Authors: Achelle Sylvain , Rodríguez‐López Julián , Bureš Filip , Robin‐le Guen Françoise 
Published: October 2019

AbstractConjugated push‐pull molecules that incorporate nitrogen heterocycles as electron‐withdrawing units are interesting materials because of their luminescence properties. These chromophores can be easily and reversibly protonated at the nitrogen atom of the heterocyclic ring and this can cause dramatic color changes. White and multi‐color photoluminescence both in solution and in the solid state can be obtained by an accurate control of the amount of acid. Thus, with a suitable design these compounds have potential applications in the development of colorimetric pH sensors and the fabrication of OLEDs based on only one material. We provide here a brief overview of our collaborative efforts made in this area.
The benefits differential equations bring to limb development
Authors: Fowler Donald A. , Larsson Hans C. E. 
Published: October 2019

AbstractSystems biology is a large field, offering a number of advantages to a variety of biological disciplines. In limb development, differential‐equation based models can provide insightful hypotheses about the gene/protein interactions and tissue differentiation events that form the core of limb development research. Differential equations are like any other communicative tool, with misuse and limitations that can come along with their advantages. Every theory should be critically analyzed to best ascertain whether they reflect the reality in biology as well they claim. Differential equation‐based models have consistent features which researchers have drawn upon to aid in more realistic descriptions and hypotheses. Nine features are described that highlight these trade‐offs. The advantages range from more detailed descriptions of gene interactions and their consequence and the capacity to model robustness to the incorporation of tissue size and shape. The drawbacks come with the added complication that additional genes and signaling pathways that require additional terms within the mathematical model. They also come in the translation between the mathematical terms of the model, values and matrices, to the real world of genes, proteins, and tissues that constitute limb development. A critical analysis is necessary to ensure that these models effectively expand the understanding of the origins of a diversity of limb anatomy, from evolution to teratology.This article is categorized under:
Vertebrate Organogenesis > Musculoskeletal and Vascular
Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms
Establishment of Spatial and Temporal Patterns > Repeating Patterns and Lateral Inhibition
#(Me)too much? The role of sexualizing online media in adolescents’ resistance towards the metoo‐movement and acceptance of rape myths
Authors: Maes Chelly , Schreurs Lara , van Oosten Johanna M.F. , Vandenbosch Laura 
Published: October 2019

ABSTRACTIntroductionThe current study addresses how sexualizing online media practices, i.e., exposure to sexually explicit internet material and receiving negative appearance feedback on social media, relate to the acceptance of sexist attitudes among adolescents. Specifically, it extends previous research on the acceptance of rape myths by exploring a construct related to these beliefs, i.e., resistance towards the metoo‐movement.MethodsThe study is based on a cross‐sectional paper‐and‐pencil survey among 568 Flemish adolescents (15–18 years old, Mage = 16.4, SD = .98, 58.3% girls) that measured adolescents’ sexualizing online media use, sexist attitudes and objectification processes.ResultsThe results showed that exposure to sexually explicit internet material, but not receiving negative appearance feedback on social media, was related to more resistance towards the metoo‐movement and the acceptance of rape myths through notions of women as sex objects. Self‐objectification did not function as a valid mediator in the examined relations. Gender and self‐esteem did not moderate the proposed relations.ConclusionsThe findings underline the role of media use in how adolescents develop sexist beliefs and, more precisely, beliefs about contemporary actions to combat sexism, i.e., the metoo‐movement. The present study showed that sexual objectification fueled by sexually explicit internet material may result in less positive attitudes and, thus, more resistance towards this movement.
On the role of person features in the evidential-temporal connection
Authors: Pancheva Roumyana , Zubizarreta Maria Luisa 
Published: October 2019

AbstractThe present article argues that temporality can be computed indirectly via evidentiality, and that this is the case for Paraguayan Guaraní, a tenseless language. To model the evidential–temporal connection, we employ features from the domains of person (author, participant) and general deixis (proximate, distal). We discuss in detail the case of two evidential morphemes: indirect evidentialra'eand reportativeraka'e.We argue that these particles do not have temporal semantics; rather their temporal contribution is due to the interaction of person features that determine the type of evidentiality and deictic features incorporated into the person system.
Injury Patterns and Medical Evacuation of Patients in Chifeng Tornado in China, August 11, 2017
Authors: Zhao Fangjie , Hu Chaoqun , Xu Zhenqing , Deng Qiangyu , Wu Yaomin , Zhang Lulu 
Published: October 2019

AbstractObjectives:To study injury patterns and medical rescue operations related to tornadoes that occur in rural areas, this study investigated the data pertaining to the 2017 Chifeng tornado (China).Methods:Medical records of 52 tornado-related patients were investigated. Data were collected from 3 local hospitals that received all the tornado victims.Results:A total of 148 injuries were diagnosed. Tornado-related injuries were mainly caused by collapsed houses (51.9%) and direct physical trauma caused by the tornado (38.5%). Most injuries occurred outdoors (63.5%). The head (20.3%) and thorax (14.8%) were most 2 frequent anatomical injury sites. Soft-tissue injuries (43.9%) and contusions and lacerations (37.3%) were the 2 most common injury types. On evaluating the Abbreviated Injury Scale scores, a score of 1 was the most common (66.2%), and a score of 6 was not recorded.Conclusions:A trailing phenomenon in the distribution of time to admission among the victims of a particular tornado in China was observed. The delivery is timely compared with nondisaster situation. There was a statistically significant difference of injury causes between outdoor and indoor patients. Helmets should be used by potential tornado victims. Basement units capable of functioning as shelters should be built in villages.
Health outcomes attributable to carbapenemase-producing Enterobacteriaceae infections: A systematic review and meta-analysis
Authors: Budhram Dalton R. , Mac Stephen , Bielecki Joanna M. , Patel Samir N. , Sander Beate 
Published: October 2019

AbstractBackground:Carbapenemase-producing Enterobacteriaceae (CPE) pose a significant global health threat.Objective:To conduct a systematic review of health outcomes and long-term sequelae attributable to CPE infection.Methods:We followed PRISMA reporting guidelines and published our review protocol on PROSPERO (CRD42018097357). We searched Medline, Embase, CINAHL and the Cochrane Library. We included primary studies with a carbapenem-susceptible control group in high-income countries, published in English. Quality appraisal was completed using Joanna Briggs Institute checklists. We qualitatively summarized frequently reported outcomes and conducted a meta-analysis.Results:Our systematic review identified 8,671 studies; 17 met the eligibility criteria for inclusion. All studies reported health outcomes; none reported health-related quality-of-life. Most studies were from Europe (65%), were conducted in teaching or university-affiliated hospitals (76%), and used case-control designs (53%). Mortality was the most commonly reported consequence of CPE-infections; in-hospital mortality was most often reported (62%). Our meta-analysis (n = 5 studies) estimated an absolute risk difference (ARD) for in-hospital bloodstream infection mortality of 0.25 (95% confidence interval [CI], 0.17–0.32). Duration of antibiotic therapy (range, 4–29.7 vs 1–23.6 days) and length of hospital stay (range, 21–87 vs 15–43 days) were relatively higher for CPE-infected patients than for patients infected with carbapenem-susceptible pathogens. Most studies (82%) met >80% of their respective quality appraisal criteria.Conclusions:The risk of in-hospital mortality due to CPE bloodstream infection is considerably greater than carbapenem-susceptible bloodstream infection (ARD, 0.25; 95% CI, 0.17–0.32). Health outcome studies associated with CPE infection are focused on short-term (eg, in-hospital) outcomes; long-term sequelae and quality-of-life are not well studied.Trial Registration:PROSPERO (CRD42018097357).