bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic and prognostic value of H2AFY in hepatocellular carcinoma
Authors: ma xuyang , Ding Ying , Zeng Li 
Published: March 2020

Abstract
Background The potential correlation between H2AFY (also known as MacroH2A1) and the clinical characteristics of hepatocellular carcinoma (HCC) patients was analysed through gene expression profiles and clinical data in The Cancer Genome Atlas (TCGA) database, and the diagnostic and prognostic value of H2AFY in HCC was discussed. Methods The gene expression data of HCC and the corresponding clinical characteristics of HCC patients were downloaded from the TCGA database. The differences in H2AFY in normal liver tissues and HCC were analysed. The relationship between H2AFY and clinical characteristics was analysed by Wilcoxon signed-rank test, logistic regression and Kruskal-Wallis test. The Kaplan-Meier method and the Cox regression method were used to analyse the relationship between overall survival and clinical characteristics of the patients. An ROC curve was used to predict the diagnostic value of H2AFY in HCC. Gene set enrichment analysis (GSEA) was used to analyse the pathway enrichment of H2AFY. Result Compared with normal liver tissues, H2AFY was significantly highly expressed in HCC. H2AFY was positively correlated with the age, clinical stage, G stage and T stage of liver cancer patients. Higher H2AFY expression predicted a poor prognosis in HCC patients. Cox regression analysis suggested that H2AFY was an independent risk factor for the prognosis of HCC patients. The ROC curve suggested that H2AFY had certain diagnostic value in HCC. GSEA suggested that H2AFY was correlated with lipid metabolism and a variety of tumour pathways. Conclusion Our study showed that H2AFY was significantly overexpressed in HCC. H2AFY may be a potential diagnostic and prognostic marker for HCC, and high expression of H2AFY predicts a poor prognosis in patients with HCC.
Prevalence and Risk Factors of Chronic Kidney Disease among Palestinian Diabetic Patients: a Cross Sectional Study
Authors: Nazzal Zaher , Hamdan Zakaria , Masri Donia , Abu-Kaf Oday , Hamad Mohammad 
Published: March 2020

Abstract
Background Chronic kidney disease (CKD) is a worldwide public health problem and diabetes is one of major risk factor for its development and progression. The aim of this study is to assess the prevalence of chronic kidney disease in a cross-sectional population of patients with type 2 diabetes treated in primary health care centers in North West Bank. Methods Patients’ data including patient characteristics, creatinine level, blood pressure, HbA1c, and hypertension and diabetes duration was collected from primary health care centers. eGFR was calculated using the CKD-EPI equation. CKD was staged according to the Kidney Disease Improving Global Outcomes System (KDIGO) 2012 guidelines. Both univariate and multivariate statistical analysis was conducted using SPSS. Results The prevalence of chronic kidney disease among diabetic adults in North West Bank was found to be 23.6% (95% CI: 19.4%-28.1%) distributed as follows: 19.7% had stage 3 CKD, 2.6% had stage 4 CKD and 1.3% had stage 5 CKD. In multivariate logistic regression, CKD was significantly associated with hypertension [adjusted OR= 4.43, P value=0.005], smoking [adjusted OR= 2.1, P value=0.01], and age [adjusted OR= 1.1, P value <0.001] Conclusions CKD is highly prevalent among Palestinian diabetic adults. Co-morbid hypertension, smoking and older age were found to increase the probability of developing this condition. Intensive screening for diabetic patients to detect CKD at earlier stages and implementation of more aggressive treatment modalities for diabetes as well as other important risk factors, especially hypertension and smoking are recommended.
Feasibility and impact of laparoscopic sleeve gastrectomy after renal transplantation on comorbidities, graft function and quality of life.
Authors: Alenazi Naif , Ahmad Khaled S , Elsamahy Ilham A , Essa Mohamed S 
Published: March 2020

Abstract
Background The aim of this study is to clarify the feasibility and effect of laparoscopic sleeve gastrectomy (LSG) on comorbidities, graft function and quality of life in patients under went renal transplantation (RT) Methods This is a retrospective review of 5 patients who underwent laparoscopic sleeve gastrectomy (LSG) after kidney transplantation. Patients demographic data, anthropometric parameters, effect on comorbidities, postoperative course, immunosuppressive medications, cause of renal transplantation (RT), renal function, survival of graft, and post-sleeve gastrectomy quality of life in obese patients with history of renal transplantation (RT) were assessed using BAROS–Moorhead–Ardelt survey Results From September 2015 to September, 2019, 5 renal transplant patients underwent underwent laparoscopic sleeve gastrectomy (LSG); 60% were female and 40 were male with an average body mass index (BMI) before surgery of 41.28 ± 5.8 kg/m2 (range 36–55). Associated comorbidities: 100% of the patients had hypertension (HTN) and dyslipidemia (DSL), Whereas 3 patients (60%) had type 2 diabetes mellitus (T2D) and 1 patient had gout (20%). The average time between renal transplantation (RT) and laparoscopic sleeve gastrectomy (LSG) was 5.6 ± 5 years (range 3–9). Average operative duration was 61 ± 16.5 min (range 50–70), and there were neither postoperative morbidity nor mortality. At 17.9 ± 13.6 months (range 7–48) of follow-up period, body mass index (BMI) was 28.8 ± 6.3 kg/m2 (range 25–42). Regarding patients with hypertension (HTN) and dyslipidemia (DSL), improvement in blood pressure, triglyceride and cholesterol levels was observed and all cases were able to decrease their medications. Regarding diabetic patients, insulin was stopped in all patients and replaced with oral hypoglycemic medication only (linagliptin). Renal graft function and proteinuria level decreased in all cases (100%). All patients claimed to have excellent quality of life. Conclusion LSG showed excellent outcomes regarding weight reduction, improvement and resolution of comorbidities, kidney function and quality of life in this high risk group of patients.
Biochemical and molecular resistance mechanisms to DDT and some pyrethroid insecticides in vector of West Nile virus, Culex pipiens
Authors: Salim-Abadi Yaser , Vatandoost Hassan , Oshaghi Mohammad Ali , Abai Mohamad Reza , Enayati Ahmad Ali , Gorouhi Mohammad Amin 
Published: March 2020

Abstract
Objectives : Culex pipiens complex act as an important vector of several vector-borne diseases such as filariasis, West Nile virus, Japanese encephalitis and bird malaria. This study was designed in order to clarify the molecular and biochemical resistance mechanisms in Cx. pipiens to DDT and some pyrethroid insecticides from Tehran, capital of Iran.Materials and methods Profile activities of α- and ß-esterases, Mixed Function Oxidase (MFO), Glutathione-S Transferase (GST), were tested for Cx .pipiens strain with resistance ratio of 85.75 to Lambdacyhalothrin and also about DDT resistant strain in comparison with Lab strain. In the present research a molecular study also performed on both lambdacyhalothrin and DDT. Resistant strains for detection of the mutation in the sodium channel gene which is associated with kdr insecticide resistance to pyrethroid and DDT were used . For comparison of average between two groups T test were used.Results Our finding showed that there are significant different (p<0.05) between the mean activity of α-, ß-esterases and (MFO), in both lambacyhalothrin and DDT resistant strain in comparison with Lab-Strain, but there are no significant difference (p>0.05) about (GST) in the both strain in comparison with Lab-Strain. Molecular study for detection of L1014F or L1014S mutation in sodium channel gene showed lack of the mutation responsible for insecticide resistance to pyrethroid and DDT.Discussion This study showed that the resistance to pyrethroids and DDT in the Cx pipiens is enzymatic, but not targets site insensitivity of sodium channel gene.Conclusion Findings of this research could provide a clue for logical operations of future chemical control program.
Effect of homeownership on the utilization of local public health services among rural migrants in China: a nationwide cross-sectional study
Authors: Wang Zicheng , Liu Jiachun , Ming Juan 
Published: March 2020

Abstract
Background: Rural-urban migrants often suffer overrepresented health risks but have less access to public health services，while the homeownership status in China may play a vital role in the attainment of local welfare. However, the effect of homeownership on the public health services utilization is still understood. This study aims to address the causal effect of homeownership on the utilization of local public health services among rural migrants in China. Three issues are addressed to discuss: Whether the homeownership produces a significant effect on the utilization of local public health services or not? Are there any interaction effect between homeownership and location of household/ healthcare center? Does the homeownership effect vary by employment status, migration duration and migration patterns?Methods: The dataset from the 2017 National Migrants Population Dynamic Monitoring Survey (NMPDMS-2017) is applied to explore the direct effect of homeownership on the utilization of local public health services. The Logit regression is conducted to discuss the associations, while the IV estimation developed by Lewbel (2012) is employed to correct the endogeneity of homeownership. Additionally, the Logit regressions are also performed to explore the interaction effect and heterogeneous effect.Results: The Logit estimations reveal that the homeownership is positive with the establishment of health record (OR=1.1926; 95% CI=1.154,1.2325) and the attendance of health education (OR=1.1883; 95% CI=1.1506,1.2271) ,while IV estimations also confirms that the homeownership has a positive effect on the establishment of health record (Coefficient=0.0222; 95% CI=0.0121, 0.0323) and the health education access (Coefficient=0.0241; 95% CI=0.0139, 0.0343).The interaction term of homeownership and household location (Coefficient=1.4141; 95% CI= 1.2453, 1.6057) as well as the interaction between homeownership and healthcare center location (Coefficient=1.1476; 95% CI= 1.0491, 1.2554) are related with the increased establishment of health record establishment, whereas only the interaction of homeownership and household location shows significant correlations in the health education model(Coefficient=1.2186; 95% CI=1.0734, 1.3794).Conclusion: The homeownership produces a positive effect on the utilization of local public health services among rural migrants in China. Moreover, the homeownership may play a greater role along with the geographical accessibility.
Description of Seinura italiensis n. sp. (Tylenchomorpha: Aphelenchoididae) found in the medium soil imported from Italy
Authors: Gu Jianfeng , Maria Munawar , Liu Lele , Pedram Majid 
Published: March 2020

Abstract

Seinura italiensis n. sp. isolated from the medium soil imported from Italy is described and illustrated using morphological and molecular data. The new species is characterized by having short body (477 (407-565) µm and 522 (469-590) µm for males and females, respectively), three lateral lines, stylet lacking swellings at the base, and excretory pore at the base or slightly anterior to base of metacorpus; females have 58.8 (51.1-69.3) µm long post-uterine sac (PUS), elongate conical tail with its anterior half conoid, dorsally convex, and ventrally slightly concave and the posterior half elongated, narrower, with finely rounded to pointed tip and males having seven caudal papillae and 14.1 (12.6-15.0) µm long spicules. Morphologically, the new species is similar to S. caverna, S. chertkovi, S. christiei, S. hyrcania, S. longicaudata, S. persica, S. steineri, and S. tenuicaudata. The differences of the new species with aforementioned species are discussed. In molecular phylogenetic analyses using near full-length small and large subunit ribosomal DNA (SSU and LSU rDNA D2-D3 expansion segments) sequences, the new species fell into a clade including three previously described/sequenced species of the genus in both SSU and LSU Bayesian phylogenetic trees.
Alternative approach to moments of order statistics from one-parameter Weibull distribution
Authors: Rai Piyush Kant , Sirohi Anu 
Published: March 2020

Abstract
The Weibull distribution is used to describe various observed failures of phenomena and widely used in survival analysis and reliability theory. Sometimes it is very difficult to compute moments of such distributions due to various reasons for e.g. analytical issues, multi parameter cases etc. This study presents the computation of the moments and the expected value of the product of order statistics in the sample from the one-parameter Weibull distribution. An alternative approach in connection to survival function is used to obtain these moments and expected values. In addition the characteristic function of the above distribution is also obtained in the form of gamma functions. Further an illustration is shown to find the first two moments and expected value of the product of order statistics by using this approach.
EL PEI, un instrumento pedagógico que al reflexionar sobre la memoria colectiva del conflicto armado posibilita un aprendizaje en torno al dolor y sufrimiento
Authors: Mosquera Mosquera Carlos Enrique , Rodríguez Lozano María Nelsy 
Published: March 2020

Al interpretar el Proyecto Educativo Institucional (PEI) a partir de las categorías de subjetividad política y memoria colectiva del conflicto armado, encontramos que: i) la escuela haciendo uso de los 5 componentes del PEI puede hacer pedagogía de la memoria sobre las dimensiones del conflicto armado, ii) la escuela puede resignificar los actos cívicos creando actividades pedagógicas que comporten nuevos sentidos sobre la violencia de pais al motivar la reflexión en los sujetos educativos, iv) es posible una educación desde el lenguaje poético como grito y silencio de las víctmas, v) haciendo pedagogía de la memoria del conflicto armado, la escuela puede propiciar la unión en la comunidad educativa en torno al dolor y sufrimiento, posibilitando una reelaboración imaginativa del dolor físico a sufrimiento, constituyéndose éste, en un tipo de enseñanza y apredizaje.
Orientaciones emocionales colectivas sobre el conflicto armado y sus actores como barreras para la construcción de la paz y la reconciliación en Colombia
Authors: Villa Gómez Juan David , Rúa Álvarez Susana , Serna Natalí , Barrera Machado Daniela , Estrada Atehortúa Carlos Esteban 
Published: March 2020

El presente artículo de investigación analiza orientaciones emocionales colectivas de carácter político como barreras psicosociales para la construcción de la paz y la reconciliación en Colombia. Se realizaron 55 entrevistas semiestructuradas y en profundidad a ciudadanos del común en la ciudad de Medellín, de las que emergieron discursos relacionados con estas orientaciones emocionales, dirigidas al proceso de negociación política del conflicto armado entre el gobierno colombiano y la guerrilla de las Fuerzas Armadas Revolucionarias de Colombia – Ejército del Pueblo (FARC- EP). Se identificaron diversas orientaciones emocionales como ira, indignación y odio, dirigidas hacia las FARC, especialmente por los participantes que se mostraron en desacuerdo. Mientras que, quienes estaban de acuerdo, en menor medida expresaron este tipo de emociones hacia paramilitares. Sin embargo, hacia la fuerza pública, los tres grupos categorizados expresaron orientaciones emocionales de admiración, orgullo y sentimiento de patriotismo. De otro lado, la esperanza y la empatía como posibilitadoras de escenarios de transformación del conflicto armado primaron en quienes se encontraban de acuerdo. Finalmente, la tristeza y el dolor emergieron en la mayoría de los participantes, pero en quienes estaban de acuerdo se asoció con solidaridad hacia las víctimas y deseo de transformar la guerra en Colombia por la vía de la negociación política.
The Implementation of Role of Kuttab Al-Fatih (KAF) Philosophy in Islamic Character Education
Authors: Hafnidar Hafnidar , Mansor Rosnidar , Nichiappan Suppiah 
Published: March 2020

The aim of study was to understand about the implementation of role of kuttab al fatih (KAF) philosophy in islamic character education. This research used qualitative method. The study revealed that the KAF philosophies are "the faith before the Quran” “the adab before the knowledge" and “the knowledge before the actions (‘amal), which are believed to aid KAF to achieve its vision and mission. The implementation of KAF Philosophies in Islamic character education creates a solid foundation of faith which contains basic values for students who contain character good personalities such as obedient, responsible, disciplined, hard-working, long term concentration or focus, away from prohibitions, vices, sincere, be grateful, and motivated because of Allah. KAF philosophies delivered to all parties in KAF included students, parents, teachers, management, staff Foundation, cleaning service and driver. AbstrakTujuan dari penelitian ini adalah untuk memahami tentang implementasi peran filosofi kuttab al fatih dalam pendidikan karakter Islami. Penelitian ini menggunakan metode kualitatif. Studi ini mengungkapkan bahwa filosofi KAF adalah "Iman sebelum Quran" "Adab sebelum Ilmu""Ilmu sebelum tindakan (amal), yang diyakini membantu KAF untuk mencapai visi dan misinya. Penerapan KAF Philosophies dalam pendidikan karakter Islam menciptakan fondasi iman yang solid yang berisi nilai-nilai dasar bagi siswa yang mengandung karakter kepribadian yang baik seperti taat, bertanggungjawab, disiplin, pekerja keras, konsentrasi atau fokus jangka panjang, jauh dari larangan, kejahatan, tulus, bersyukur, dan termotivasi karena Allah. Filosofi KAF disampaikan kepada semua pihak di KAF termasuk siswa, orang tua, guru, manajemen, staf Yayasan, layanan kebersihan dan sopir.
ASEMPTOMATİK HALLUKS VALGUSLU BİREYLERDE TEK AYAK ÜZERİ DENGE PERFORMANSININ İNCELENMESİ
Authors: TAŞ Serkan , BEK Nilgün , ÇETİN Alp 
Published: March 2020

Amaç: Bu çalışmanın amacı, halluks valguslu (HV) bireylerde tek ayak üzeri denge performansının
araştırılarak sağlıklı kontrol grubu ile karşılaştırılmasıydı.
Yöntem: Bu çalışmaya, 20-57 yaş aralığında (32,57±10,15 yıl) iki erkek ve 21 kadın olmak üzere toplam
23 asemptomatik HV olan birey dahil edildi. Kontrol grubu ise 19-58 yıl yaş aralığında (33,36±10,53
yıl) iki erkek ve 23 kadın olmak üzere 25 bireyden oluşturuldu. Bireylerin ayak başparmağı pozisyonu
Manchester Skalası kullanılarak, halluks açısı ise gonyometre ile değerlendirildi. Tek ayak üzerinde
denge performansı ve postüral salınım miktarının ölçümü Biodex Denge Sistemleri kullanılarak
değerlendirdi. Tek ayak üzerinde denge performansının değerlendirilmesi amacıyla denge skorları
anteroposterior, mediolateal ve ortalama skor olmak üzere hesaplandı. Ayrıca testler esnasında, denge
merkezinden sapmaların standart deviasyonu anteroposterior ve mediolateral yönde hesaplandı.
Sonuçlar: Her iki grubun ortalama değerleri, anteroposterior ve mediolateral skorları arasında
anlamlı fark yoktu (p>0,05). Her iki gruba ait ortalama değerler, anteroposterior ve mediolateral
yönde denge merkezinden sapmaların standart deviasyonu da birbirine benzerdi (p>0,05). Ayak
parmağı halluks açısı ile ortalama, anteroposterior ve mediolateral skor arasında anlamlı ilişki yoktu
(p>0,05). Bireylerin yaşı ile değerlendirilen denge parametreleri arasında ilişki bulunmaz iken (p>0,05),
bireylerin boy, vücut ağırlığı ve vücut kütle indeksi (VKİ) değerleri ile denge skorları arasında düşük
düzeyden kuvvetliye değişen ilişki olduğu belirlendi (r=0,314-0,692, p
Plant water resource partitioning and xylem-to-leaf deuterium enrichment in Lanzhou, northwest China
Authors: Du Qinqin , Zhang Mingjun , Wang Shengjie , Argiriou Athanassios A. , Che Cunwei , Zhao Peipei , Ma Zhuanzhuan , Su Pengyan 
Published: March 2020

AbstractLanzhou lies at the western Loess Plateau, China, and has a typical semi-arid temperate continental climate. Plants in this area are exposed to a prolonged dry season. In this study, we measured the stable isotopes of hydrogen (δD) and oxygen (δ18O) of the local precipitation, river water, soil water, plant xylem water, and leaf water at four sampling sites during the 2016 growing season. Our results showed that plants relied mostly on wet season precipitation at sites N1, N2, and N3 because this recharged the soil after the long dry season. Leaf phenology had a significant effect on evaporation distance (ED) value, and evergreen plants have adapted to water tapping from deep soil water sources during the dry season. The ED values of trees and shrubs were quite different in the dry season, indicating water competition among different plant species was mitigated due to water resource partitioning. Moreover, plants at site N4 relied on a water source admixed with river water throughout the whole growing season. The mean value of xylem-to-leaf water deuterium enrichment (ɛl/x) was −0.91 ± 0.36‰ over all plant species, seasons, and sampling sites. Plant species, leaf phenology, and seasons were found to be the primary factors influencing the ɛl/x, while growth form and elevation had negligible effects.
Fate and behaviour of acetaminophen, 17α-ethynylestradiol and carbamazepine in aqueous solution
Authors: Santos Albano Joel Moreira , Cardoso Cláudia Sofia Gomes , Mota Albertina Alice Ribeiro , Belmonte Patrícia Raquel Heleno , Oliveira Manuel António Campo Grande , da Silva Joaquim Carlos Gomes Esteves 
Published: March 2020

Abstract
Pharmaceuticals are invaluable tools for the prevention and treatment of human and animal diseases. Human evolution led to the increase of life expectancy, which promoted the increase of consumption of pharmaceuticals. These compounds are consistently detected in superficial waters, and whilst degradation processes are expected to mitigate their levels, they also induce the formation of potentially harmful by-products. The compounds studied in this work were acetaminophen, 17α-ethynylestradiol and carbamazepine. High-performance liquid chromatography coupled with ultraviolet diode-array detection was used to follow the degradation reactions, whilst liquid chromatography associated with ultraviolet diode-array detection and mass spectrometry was applied in the determination of by-products. Ethynylestradiol proved to be the most reactive (t1/2 = 38.6 ± 1.9 seconds) and carbamazepine the least reactive (t1/2 = 481.4 ± 16.7 minutes) when exposed to active chlorine. In relation to disinfection by-products, two monochlorinated analogues were detected for acetaminophen, one monochlorinated for carbamazepine, and one mono- and one trichlorinated for ethynylestradiol. Chlorine levels and water pH proved to be the most influential variables on the degradation of the compounds, with and without dissolved organic matter in solution. All pharmaceuticals displayed significant photostability towards artificial solar radiation, with acetaminophen being slightly more stable.