bluuebunny/crossref_metadata_2025_split huggingface dataset:
River water classification pattern in Malang city based on electronic tongue for identification of environmental pollution
Authors: Tazi Imam , Margareta Silvi Nadya , Setyandita Wanda Yulia , Muttamaqin Hermawan , Kulliyana Shilfi Khoirotin , Muhaimin Aep , Muthmainnah  
Published: February 2020

Abstract
The e-tongue in this study was developed in 16 lipid membrane-based sensor channels. Each membrane lipid arrange by different polymer membranes. Membranes are made by combining polyvinyl chloride (PVC) as a matrix. Four different types of plasticizers (2-NPOE, bis (2-Ethylhexyl) Pthalate, bis (2-Ethylhexyl) phosphate, bis (1-butyl pentyl) adipate). Four types of lipids (octadecylamine, oleyl alcohol, methyltrioctylammonium chloride, and oleic acid) for active ingredients. This electronic tongue is used to classify river water pollution in Malang City from various sources. The data obtained were analysed using the PCA (Principal Component Analysis) method. Based on the PCA score plot shows the value of PC1 = 49.18%, and PC2 = 20.09%. Based on the loading plot shows the sensors that have the greatest contribution in classifying river water pollution are sensor 5, sensor 6. The PCA pattern shows that the river in front of UIN Malang, the river around Sumbersari and the river around Landungsari have a very close pattern. The data obtained show that the source of pollution of the three rivers is almost the same. The river around Soekarno Hatta and the river around Merjosari have a different pattern from the other three rivers. It can be concluded that using the PCA method can distinguish the classification of river water in different places.
Description of The Number Theory Course Problem Solving Abilities Basen on Personality Type of The Math Student at Universitas Darussalam Ambon
Authors: Kasriana  , Ode R 
Published: February 2020

Abstract
This research is a qualitative research, which aims to describe students in solving problems based on each personality type. The results showed that: (1) understand the problems the guardian wrote qualified enough and need; (2) was making plans the subject could detect information to complete about; (3) in implementing the plan doing it in accordance with the subject but incorrect. (1) understand the problems the subject of idealist only record that asked; (2) was making plans the subject could detect formula; (3) carry out a plan the subject of using formulas were formerly, although one measure. (1) understand the problems the subject of type artisan wrote very clearly all information is; (2) was making plans the subject of determining. formula(3) implement plan, problem solving able to solve. (1) understand the problems the subject type rational not have inscribed requirements enough and the requirements necessary; (2) was making plans subject to determine the steps the; (3) implement plan, problem solving skilled in algorithms and accuracy.
Utilization of Pectin Isolated from Orange Kisar (Citrus sp) peel as Phenol Adsorbent
Authors: Tanasale M F J D P , Latupeirissa J , Fransina E G , Batawi C Y 
Published: February 2020

AbstractPectin isolated from orange kisar (Citrus sp) peel has been used as phenol adsorbent. The ability of the pectin as phenol adsorbent was examined at several contact times, pHs, and phenol concentrations. Determination of phenol adsorption was carried out by UV-Vis spectrophotometry method. The optimum conditions of phenol adsorption by the pectin were obtained at the contact time of 20 minutes, pH 3.0, and phenol concentration of 25 ppm. Phenol adsorption by the pectin follows the nonlinear model of the Freundlich adsorption isotherm with the correlation coefficient (r2), Freundlich’s constant (KF), and indicator of concentration dependence (n) were 99.51%, 0.6439 (mg/g) (L/mg)(1/n), and 1.620, rescpectively.
Properties Activity of Yeast Against Seaweed Bioethanol Fermentation Time and Its Functional Group
Authors: Loupatty V D , Radiena M S Y 
Published: February 2020

Abstract
The activity of yeast in relationship with fermentation time of seaweed bioethanol and functional groups formed. The bioethanol fermentation process begins with the liquification process which is the cooking stage with the addition of water as much as 50 times the weight of seaweed, cooked until it boils. Saccharification is the step of adding bean sprouts to seaweed filtrate at a temperature ± 90°C. For the breakdown of polysaccharides into glucose. Fermentation, carried out at a temperature ± 30°C, by adding about 0.02% yeast. Furthermore, anaerobic fermented for second days; thirth days; fourth days; fifth days and sixth days. The bioethanol obtained were then analyzed with spectroscopic IR. The results showed that the functional group formed was –OH in absorption 3600 – 3200 cm−1. Reinforced of absorption C – O, 1200 – 1000 cm−1, shows the presence of the alcohol compound, consist of tertiary alcohol and secondary alcohol. Primary alcohol, only appears on 2nd day and 4th day. Thus it can be said that the activity of yeast (Saccharomyces cerevisiae) can break the primary alcohol bond on 3rd day and up.
Epidermal Growth Factor as Trigger Mitotic Cleavage in Goat Cumulus Cell
Authors: Baszary Ch D U , Moniharapon M 
Published: February 2020

Abstract
The success of oocyte maturation is strongly influenced by the rate of expansion of cumulus cells. Cumulus cell expansion is inseparable from cell multiplication through mitotic division which is triggered by several factors, one of which is the growth factor, namely Epidermal Growth Factor (EGF). An increase in the number of cells undergoing mitosis can be used as an indicator of the quality of cumulus cell expansion. The treatments in this study were EGF concentrations of 0 ng/ml, 50 ng/ml, 100 ng/ml, and 200 ng/ml. Observation method with BrdU-PI (Bromodeoxyuridine-Propidium iodide) Flowcytometry. The results showed that the cells that experienced the most mitosis were EGF 200 ng/ml treatments with the amount of 25.79%.
Antimalarial Effect of Lemburung Meit (Clerondrum Inerme Linn) Stew on Malarial Infections at Piru Health Center, West Seram District, Maluku
Authors: Nindatu M , Titaley C R , Taihuttu Y , Kaihena M 
Published: February 2020

Abstract
Antimalarial effect assay from Lemburung meitt (Cloredendrum inerme) has been done. Plant have been used as a source of medicine it is commonly known as “lamburung meit” and All parts of the plants is used traditionally as malarial disease. This research was aimed to evaluate the toxicity and antimalarial activity of lamburung meit (Clerodendrum inerme) stew water. It was quasi experiment with clinical observation desain and 30 patients using exclusion and inclusion criteria. The result showed that lamburung meit (Clerodendrum inerme Linn) stew water can reduce the density of malaria parasite from day 3 SGOT, SGPT, ureum and creatinine levels do not change after the used of material test. The findings indicated that lamburung meit (Clerodendrum inerme Linn) stew water exhibited potent antimalarial activities and does not cause toxicity effects on the liver and kidneys. Therefore, the compounds are potentially developed into novel antimalarial drugs.
Back Calculation of Slope Stability in Batu Gadjah, Ambon City Using
the Solution of Analytical and Finite Element Method
Authors: Souisa M , Sapulete S M , Tuarissa J C 
Published: February 2020

Abstract
At the time of entering the rainy season from year to year in the Maluku region,
especially the Ambon Island area experienced an increase in landslides due to
rainfall, human activities such as excavation under the slopes, loss of
vegetation, changes in land use and so on. The disaster that occurred on RT.03 /
RW.01 Batu Gadjah Village, Sirimau Subdistrict, Ambon City, on June 1, 2018,
ago, still leaves a trace of damage that until now. In this study, the
researcher will analyze the slope (deformation that occurs) in the 2D model
using Finite Element Method (FEM), by reviewing the weathering conditions of the
rocks that are read from the results of the drill data in the form of soil
properties and variations in rising groundwater levels. The results of
calculations using FEM on dry slope conditions obtained the value of safety
factor (FS) 1.10 and the analytical of FS value 1.18. This FS value indicates
that the study area is still prone to landslides. Then the calculation with FEM
on the wet slope conditions by rainwater obtained an FS value of 0.90, and
analytically the FS value of 0.99. This FS value indicates that the research
area has experienced a landslide.
Multifunctional Nanowires and Hierarchical 3D Nanostructures of Material Composites for Energy Storage
Authors: Vidyadharan B , Pal B , Misnon I I , Elim H I , Jose R 
Published: February 2020

Abstract
Composites of functional materials have long been synthesized for achieving enhanced physical and chemical properties. In this era of energy intensive electronics and electric vehicles, energy storage devices utilising composite materials could offer improved performance at a lower cost. Furthermore, if the composite materials are synthesized in one-dimensional morphology at a nano level, conductivity and thus electrical properties could be multiplied. A range of materials with different functionalities have been synthesized by our group recently; as a typical example synthesis of a composite nanowire containing NiO and CuO for supercapacitive energy storage is detailed in this paper and compared the performance of the composite wires with its component binary wires. The materials were synthesized by electrospinning technique and characterized for their structure, microstructure, surface properties and electrochemical properties. The results shows that a composite wire containing materials for similar electrical conductivity would lead to improved charge storage performance than their single component counterparts.
A Novel Hybrid GSTARX-RNN Model for Forecasting Space-Time Data with Calendar Variation Effect
Authors: Suhartono  , Hikmawati F , Setyowati E , Salehah N A , Choiruddin A 
Published: February 2020

Abstract
Recent development in space-time data forecasting includes a hybrid model. In this study, we propose a hybrid spatio-temporal model by combining Generalized Space-Time Autoregressive with exogenous variable and Recurrent Neural Network (GSTARX-RNN) for space-time data forecasting with calendar variation effect. The GSTARX model as a linear model is used to modeling space-time data with exogenous variables while the RNN model as nonlinear model is used to modeling the nonlinear patterns of the data. In particular, we employ two variants of RNNs, i.e. Elman RNN and Jordan RNN. We apply our methods on the simulation study. The results show that the proposed methods yielded more accurate forecast especially in the simulated data containing nonlinear patterns. Moreover, the GSTARX-Elman RNN as a more complex model tends to give more accurate forecast than the GSTARX-Jordan RNN.
V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single-cell RNA-seq data
Authors: Lawlor Nathan , Marquez Eladio J , Lee Donghyung , Ucar Duygu 
Published: February 2020

Abstract

Summary
Single-cell RNA-sequencing (scRNA-seq) technology enables studying gene expression programs from individual cells. However, these data are subject to diverse sources of variation, including ‘unwanted’ variation that needs to be removed in downstream analyses (e.g. batch effects) and ‘wanted’ or biological sources of variation (e.g. variation associated with a cell type) that needs to be precisely described. Surrogate variable analysis (SVA)-based algorithms, are commonly used for batch correction and more recently for studying ‘wanted’ variation in scRNA-seq data. However, interpreting whether these variables are biologically meaningful or stemming from technical reasons remains a challenge. To facilitate the interpretation of surrogate variables detected by algorithms including IA-SVA, SVA or ZINB-WaVE, we developed an R Shiny application [Visual Surrogate Variable Analysis (V-SVA)] that provides a web-browser interface for the identification and annotation of hidden sources of variation in scRNA-seq data. This interactive framework includes tools for discovery of genes associated with detected sources of variation, gene annotation using publicly available databases and gene sets, and data visualization using dimension reduction methods.

Availability and implementation
The V-SVA Shiny application is publicly hosted at https://vsva.jax.org/ and the source code is freely available at https://github.com/nlawlor/V-SVA.

Contact
leed13@miamioh.edu or duygu.ucar@jax.org

Supplementary information
Supplementary data are available at Bioinformatics online.
Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition
Authors: Risacher Shannon L , WuDunn Darrell , Tallman Eileen F , West John D , Gao Sujuan , Farlow Martin R , Brosch Jared R , Apostolova Liana G , Saykin Andrew J 
Published: February 2020

AbstractVisual deficits are common in neurodegenerative diseases including Alzheimer’s disease. We sought to determine the association between visual contrast sensitivity and neuroimaging measures of Alzheimer’s disease-related pathophysiology, including cerebral amyloid and tau deposition and neurodegeneration. A total of 74 participants (7 Alzheimer’s disease, 16 mild cognitive impairment, 20 subjective cognitive decline, 31 cognitively normal older adults) underwent the frequency doubling technology 24-2 examination, a structural MRI scan and amyloid PET imaging for the assessment of visual contrast sensitivity. Of these participants, 46 participants (2 Alzheimer’s disease, 9 mild cognitive impairment, 12 subjective cognitive decline, 23 cognitively normal older adults) also underwent tau PET imaging with [18F]flortaucipir. The relationships between visual contrast sensitivity and cerebral amyloid and tau, as well as neurodegeneration, were assessed using partial Pearson correlations, covaried for age, sex and race and ethnicity. Voxel-wise associations were also evaluated for amyloid and tau. The ability of visual contrast sensitivity to predict amyloid and tau positivity were assessed using forward conditional logistic regression and receiver operating curve analysis. All analyses first were done in the full sample and then in the non-demented at-risk individuals (subjective cognitive decline and mild cognitive impairment) only. Significant associations between visual contrast sensitivity and regional amyloid and tau deposition were observed across the full sample and within subjective cognitive decline and mild cognitive impairment only. Voxel-wise analysis demonstrated strong associations of visual contrast sensitivity with amyloid and tau, primarily in temporal, parietal and occipital brain regions. Finally, visual contrast sensitivity accurately predicted amyloid and tau positivity. Alterations in visual contrast sensitivity were related to cerebral deposition of amyloid and tau, suggesting that this measure may be a good biomarker for detecting Alzheimer’s disease-related pathophysiology. Future studies in larger patient samples are needed, but these findings support the power of these measures of visual contrast sensitivity as a potential novel, inexpensive and easy-to-administer biomarker for Alzheimer’s disease-related pathology in older adults at risk for cognitive decline.
The Origins of Anterograde Interference in Visuomotor Adaptation
Authors: Lerner Gonzalo , Albert Scott , Caffaro Pedro A , Villalta Jorge I , Jacobacci Florencia , Shadmehr Reza , Della-Maggiore Valeria 
Published: February 2020

AbstractAnterograde interference refers to the negative impact of prior learning on the propensity for future learning. There is currently no consensus on whether this phenomenon is transient or long lasting, with studies pointing to an effect in the time scale of hours to days. These inconsistencies might be caused by the method employed to quantify performance, which often confounds changes in learning rate and retention. Here, we aimed to unveil the time course of anterograde interference by tracking its impact on visuomotor adaptation at different intervals throughout a 24-h period. Our empirical and model-based approaches allowed us to measure the capacity for new learning separately from the influence of a previous memory. In agreement with previous reports, we found that prior learning persistently impaired the initial level of performance upon revisiting the task. However, despite this strong initial bias, learning capacity was impaired only when conflicting information was learned up to 1 h apart, recovering thereafter with passage of time. These findings suggest that when adapting to conflicting perturbations, impairments in performance are driven by two distinct mechanisms: a long-lasting bias that acts as a prior and hinders initial performance and a short-lasting anterograde interference that originates from a reduction in error sensitivity.
Clinical Characteristics of Imported Cases of Coronavirus Disease 2019 (COVID-19) in Jiangsu Province: A Multicenter Descriptive Study
Authors: Wu Jian , Liu Jun , Zhao Xinguo , Liu Chengyuan , Wang Wei , Wang Dawei , Xu Wei , Zhang Chunyu , Yu Jiong , Jiang Bin , Cao Hongcui , Li Lanjuan 
Published: February 2020

Abstract

Background
We aimed to report the clinical characteristics of imported cases of coronavirus disease 2019 (COVID-19) in Jiangsu Province.

Methods
We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with World Health Organization interim guidance in 3 grade IIIA hospitals of Jiangsu from 22 January to 14 February 2020. Real-time RT-PCR was used to detect the new coronavirus in respiratory samples.

Results
Of the 80 patients infected with COVID-19, 41 were female, with a median age of 46.1 years. Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. Nine patients were unconfirmed until a third nucleic acid test; 38 cases had a history of chronic diseases. The main clinical manifestations of the patients were fever and cough, which accounted for 63 (78.75%) and 51 (63.75%) cases, respectively. Only 3 patients (3.75%) showed liver dysfunction. Imaging examination showed that 55 patients (68.75%) showed abnormal density shadow and 25 cases (31.25%) had no abnormal density shadow in the parenchyma of both lungs. Currently, 21 cases have been discharged from the hospital, and no patient died. The average length of stay for discharged patients was 8 days.

Conclusions
Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptibility. The proportion of patients having liver dysfunction and abnormal CT imaging was relatively lower than that in Wuhan. Notably, infected patients may be falsely excluded based on 2 consecutively negative respiratory pathogenic nucleic acid test results.
A Single Center Experience With Long-Term Ustekinumab Use and Reinduction in Patients With Refractory Crohn Disease
Authors: Bennett Audrey , Evers Carlini Lauren , Duley Caroline , Garrett Ailish , Annis Kim , Wagnon Julianne , Dalal Robin , Scoville Elizabeth , Beaulieu Dawn , Schwartz David , Horst Sara 
Published: February 2020

Abstract

Background
Ustekinumab was approved for moderate and severe Crohn’s disease (CD) in 2016, but little is known about long-term outcomes.

Methods
A retrospective study evaluated all patients with CD treated with ustekinumab, including patients with reinduction. C-reactive protein (CRP), Harvey-Bradshaw Index (HBI), Short Inflammatory Bowel Disease (SIBDQ), and endoscopy outcomes were collected prospectively.

Results
Ninety-six patients received ustekinumab, resulting in improvement in CRP, HBI, and SIBDQ scores with 68% endoscopic improvement/remission. Thirty-four patients underwent reinduction, resulting in improved HBI and CRP.

Conclusions
Ustekinumab in refractory CD results in significant clinical and endoscopic improvement and reinduction may be a viable option to recapture response.
Effect of Constant and Fluctuating Temperature on the Development, Reproduction, Survival, and Sex Ratio of Phenacoccus solenopsis (Hemiptera: Pseudococcidae)
Authors: Waqas Muhammad Saad , Lin Lulu , Shoaib Ali Ahmed Zaky , Cheng Xinlai , Zhang Qianqian , Elabasy Asem Saad Saad , Shi Zuhua 
Published: February 2020

Abstract
Effects of temperature on the development, survival, reproduction, longevity and sex ratio of the cotton mealybug, Phenacoccus solenopsis Tinsley, was assessed at five constant temperatures ranging from 20 to 35°C and five fluctuating temperatures ranging from 15 to 40°C under laboratory conditions. Results showed that nymphal development duration, preoviposition period, oviposition period, fecundity, and adult longevity were reduced significantly with increasing temperature until 30°C, but developmental duration of third female nymphal instar and female adult longevity was longer at 35°C than 30°C, and no males could emerge from pupae at the constant temperature 35°C. Fluctuating temperature, in general, significantly accelerated the nymphal developmental duration, prolonged preoviposition period, shortened oviposition period, reduced fecundity, lowered the survival rate of nymphs, and decreased adult longevity of males and females compared to their mean corresponding constant temperature. Overall, it is suggested that one should be prudent when applying the obtained results under constant and fluctuating temperatures under laboratory conditions.
The Ross procedure is a safe and durable option in adults with infective endocarditis: a multicentre study
Authors: Chauvette Vincent , Bouhout Ismail , Lefebvre Laurence , Tarabzoni Mohammed , Chamberland Marie-Ève , Poirier Nancy , Demers Philippe , Chu Michael W A , Perron Jean , El-Hamamsy Ismail 
Published: February 2020

Abstract

OBJECTIVES
Surgical treatment of infective endocarditis (IE) remains a challenge. The Ross procedure offers the benefit of a living substitute in the aortic position but it is a more complex operation which may lead to increased operative risk. The aim of this study was to assess the safety and late outcomes of the Ross procedure for the treatment of active IE.

METHODS
From 2000 to 2019, a total of 31 consecutive patients underwent a Ross procedure to treat active IE (mean age 43 ± 12 years, 84% male). All patients were followed up prospectively. Four patients (13%) were intravenous (IV) drug users and 6 patients (19%) had prosthetic IE. The most common infective organism was Streptococcus (58%). Median follow-up was 3.5 (0.9–4.5) years and 100% complete.

RESULTS
There were no in-hospital deaths. One patient suffered a postoperative stroke (3%) and 1 patient (3%) required reintervention for bleeding. Three patients had a new occurrence endocarditis: 2 patients were limited to the pulmonary homograft and successfully managed with IV antibiotics, whereas 1 IV drug user patient developed concomitant autograft and homograft endocarditis. Overall, cumulative incidence of IE recurrence was 13 ± 8% at 8 years. The cumulative incidence for autograft endocarditis was 5 ± 4% at 8 years. Two patients (6%) died during follow-up, both from drug overdoses. At 8 years, actuarial survival was 88 ± 8%.

CONCLUSIONS
In selected patients with IE, the Ross procedure is a safe and reasonable alternative with good mid-term outcomes. Freedom from recurrent infection on the pulmonary autograft is excellent, labelporting the notion that a living valve in the aortic position provides good resistance to infection. Nevertheless, in IV drug user patients, pulmonary homograft endocarditis remains a challenge. Continued follow-up is needed to ascertain the long-term benefits of this approach.