bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caspase-8 deficiency induces a switch from TLR3-induced apoptosis to lysosomal cell death in neuroblastoma cell lines
Authors: Locquet Marie-Anaïs , Ichim Gabriel , Dutour Aurelie , Lebeque Serge , Castets Marie , Weber Kathrin 
Published: January 2020

AbstractTLR3 converts in cancer cells from an inflammatory to a death receptor and TLR3-induced cell death activates the extrinsic apoptosis pathway. Here, we demonstrate that activation of TLR3 triggers a form lysosomal cell death. Following the combinational treatment of IFN-1/poly(I:C) of the Caspase-8 deficient neuroblastoma cell line SH-SY5Y, lysosomes enlarge and accumulate before cells display characteristic apoptotic morphologies. However, caspases are not involved in signalling from TLR3 to the lysosome as 25 μM did not inhibit cell death. However, increasing zVAD concentrations to 50 μM which is known to inhibit cathepsins, as well as a specific cathepsin B inhibitor reduced TLR3-induced lysosomal cell death. Thus lysosomal cathepsins have a role in cell death execution and overtake the role of caspase-8 in inducing the apoptotic caspase cascade. Further in the caspase-8 positive neuroblastoma cell line SK-N-AS, knockdown of caspase-8 induces a switch from TLR3-induced apoptosis to lysosomal cell death. Taken together our data suggest that lysosomal cell death represents a default death mechanism, when caspase-8 is absent.
mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma
Authors: Zhao Xuyang , Ma Yadong , Cui Jie , Zhao Haiyang , Liu Lei , Wang Yueyuan , Min Pengxiang , Zhang Lin , Chen Yongchang , Du Jun , Zhang Yujie , Gu Luo 
Published: January 2020

AbstractClear cell renal cell carcinoma (ccRCC), as the most important type of renal carcinoma, has a high incidence and easy metastasis. Folliculin (FLCN) was identified as a tumor suppressor gene. Its deletions and mutations are associated with a potential risk of kidney cancer. At present, the specific molecular mechanism of FLCN-induced proliferation, invasion and migration in clear cell renal cell carcinoma remains elusive.In this study, we demonstrated that FLCN controled cell proliferation, invasion and migration through PI3K/mTORC2 pathway. FLCN combined with HIF2α in various normal and cancerous renal cells, and mTORC2 mediate FLCN effectively alleviated the deterioration of renal cancer cells by degrading HIF2α. Silencing of FLCN showed promotion of HIF2α protein expression, which in turn led to an increase in downstream target genesCyclin D1andMMP9. Moreover, when interfering with siFLCN, HIF2α degradation rate was delayed, and the time of entry into the nucleus was advanced. Taken together, our study illustrated that mTORC2 promoted the specific molecular mechanism of HIF2α by down-regulated FLCN, and might be a new therapeutic target against renal cancer progression.
How does trade openness affect female labours?
Authors: Li Jing-Ping , Li Zheng-Zheng , Tao Ran , Su Chi Wei 
Published: January 2020

PurposeThe purpose of this paper is to investigate the non-linear threshold effects between trade openness and female labours to participate in the labour markets.Design/methodology/approachThe authors consider data for nine Asian countries from 1990 to 2016 period and perform the panel threshold regression method.FindingsEmpirical results indicate that the threshold value is occurred. With the increase of trade openess, the female labour force participation rate shows a trend of rising first and then declining. Furthermore, exports also have an asymmetric threshold effect on female labour force participation, which is partly in accordance with the discrimination model (Becker, 1957). On the other hand, imports dependency will hinder female labour force participation regardless of a threshold effect. The authors obtain similar results when the authors consider the female employment rate as substitution.Practical implicationsSpecifically, increased trade openness may contribute positively or negatively towards overall female labour force participation rate (FLFPR), attributed to the relative importance of these opposing effects. Thus, when the cost reduction effect, resulting from intensified competitive pressure and comparative advantages would enhance the participation rate, the technology channel operates in the opposite direction. Therefore, from the perspective of female employment, trade openness is not the more the better.Originality/valueThis study innovatively discusses the non-linear correlation between trade openness and FLFPR and distinguishes the different contributions from exports and imports. The advanced threshold regression model assumes the existence of threshold value from trade to female employment. Thereby, targeted policies for the government should be applied to promote active female in the labour market.
Supply chain innovations for additive manufacturing
Authors: Luomaranta Toni , Martinsuo Miia 
Published: January 2020

Purpose
Additive manufacturing (AM) involves the renewal of production systems and also has implications for firms’ supply chains. Innovations related to AM supply chains are, so far, insufficiently understood, but their success will require firms’ awareness of their systemic nature and their firm-specific implications. The purpose of this paper is to explore the supply chain innovations dealing with AM in business-to-business supply chains.

Design/methodology/approach
An exploratory qualitative research design is used. Interviews were conducted in 20 firms, workshops were organized to map AM-related processes and activities, and supply chain innovations were analyzed.

Findings
This study reveals practical changes in supply chains and requirements for AM-related supply chain innovations. While earlier research has centered on technology or firm-specific AM implementations, this study shows that fully leveraging AM will require innovations at the level of the supply chain, including innovations in business processes, technology and structure, as well as supportive changes in the business environment. These innovations occur in different parts of the AM supply chain and are emphasized differently within different firm types.

Research limitations/implications
This research was conducted in one country in the context of the machine building and process industry with a limited data set, which limits the generalizability of the results. The results offer an analytical framework and identify new research avenues for exploring the innovations in partial or complete AM supply chains.

Practical implications
The results offer a framework to assess the current state and future needs in AM-related supply chain innovations. Practical ideas are proposed to enhance AM adoption throughout firms’ supply chains. These results are important to managers because they can help them position their firms and guide the activities and collaborations with other firms in the AM supply chain.

Originality/value
This study draws attention to the supply chain innovations required when firms adopt AM in their processes. The generic supply chain innovation framework is enhanced by adding the business context as a necessary component. Implementation of AM is shown to depend on the context both at the level of the supply chain and the firm’s unique role in the supply chain. The holistic view taken reveals that successful AM technology adoption requires broad involvement from different firms across the supply chain.
Impulse buying behavior: the mobile revolution
Authors: Bellini Silvia , Aiolfi Simone 
Published: January 2020

Purpose
The purpose of this paper is to investigate the role of in-store mobile usage on purchase decision making in order to understand whether and to what extent the use of the device changes the shopper behavior in terms of planned and unplanned purchases even across different retail store formats.

Design/methodology/approach
Data were obtained using a structured questionnaire from 406 respondents interviewed in hypermarket and discount stores, after the checkout. Data were measured through t-tests and the analysis of variance.

Findings
The mobile intensifies a process of preparation making it popular and the same across the different store formats, confirming how the growing convergence, making store formats less distinctive in the eyes of the consumer, has somewhat flattened and standardized the pre-shopping out-of-store preparation.

Practical implications
The pervasiveness and the versatility of the mobile, and its ability to influence the decision-making processes, leads to important managerial questions and implications regarding the effectiveness of in-store marketing initiatives and the need to review the mix of out-of-store and in-store investments, with the knowledge that the consumer will continue to become even more prepared and well informed in the future.

Originality/value
Mobile devices could be used out-of-store, as a tool for shopping preparation, and in-store as a tool for self-regulation. Therefore, it becomes crucial to understand how the mobile influences the decision-making process as well as the buying behavior of shoppers.
Gender longevity gap and socioeconomic indicators in developed countries
Authors: Fedotenkov Igor , Derkachev Pavel 
Published: January 2020

PurposeThe purpose of this paper is to explain relations between socioeconomic factors and gender longevity gap and to test a number of contradicting theories.Design/methodology/approachFixed effects models are used for cross-country panel data analysis.FindingsThe authors show that in developed countries (Organization for Economic Cooperation and Development and European Union) a lower gender longevity gap is associated with a higher real GDP per capita, a higher level of urbanization, lower income inequality, lower per capita alcohol consumption and a better ecological environment. An increase in women’s aggregate unemployment rate and a decline in men’s unemployment are associated with a higher gap in life expectancies. There is also some evidence that the effect of the share of women in parliaments has a U-shape; it has a better descriptive efficiency if taken with a four-year lag, which approximately corresponds to the length of political cycles.Research limitations/implicationsFindings are valid only for developed countries.Practical implicationsThe findings are important for policy discussions, such as designs of pension schemes, gender-based taxation, ecological, urban, health and labor policy.Social implicationsThe factors that increase male and female longevities also reduce the gender longevity gap.Originality/valueThe results contradict to a number of studies for developing countries, which show that lower economic development and greater women discrimination result in a lower gender longevity gap.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/IJSE-02-2019-0082
High-strength gears produced by powder metallurgical processes – KL500/93-2
Authors: Klocke Fritz , Broeckmann Christoph , Löpenhaus Christoph , Bezold Alexander , Frech Tim , Hajeck Marko , Scholzen Philipp , Gebhardt Christian 
Published: January 2020

Purpose
The purpose of this study is to optimize high-strength gears produced by powder metallurgical process and to provide a material model to predict the tooth root bending fatigue strength. Powder metal (PM) technology offers great opportunities for the reduction of the carbon footprint and improvement of the cost efficiency of gear production. PM gears can achieve flank load-carrying capacities comparable to wrought steel gears if the loaded volume is fully densified. Still, the tooth root strength is of particular importance.

Design/methodology/approach
The tooth root stresses can be minimized by optimizing the tooth root geometry. This usually leads to a target conflict, as fully optimized tooth root geometries cannot be manufactured by generating processes such as hobbing, generating-grinding or rolling. To use the increase in tooth root load-carrying capacity of fully optimized root geometry on PM gears, a non-generating method for surface densifying is needed. The shot-peening process is used as an alternative densification process for PM gears. The properties of both shot peened and cold-rolled PM gears are analyzed and compared. To quantify the effect of both manufacturing processes, the tooth root bending fatigue strength will be evaluated and compared to wrought gears.

Findings
From the fatigue strength perspective, a material model is developed, which is able to predict local endurable stress amplitudes. The model is gained through regression varying carbon content, density and size effect on bending specimens.

Originality/value
It is transferable to PM gears of the same material using a load transfer coefficient.
Linking resilience and organizational commitment: does happiness matter?
Authors: Paul Happy , Budhwar Pawan , Bamel Umesh 
Published: January 2020

Purpose
The purpose of this paper is to propose and empirically test a model that examines subjective well-being (SWB) components (affect balance and life satisfaction, colloquially referred to as “happiness”), as the intervening variables between resilience and organizational commitment (OC), drawing on appraisal theory and job demands‒resources model.

Design/methodology/approach
Based on an employee sample (n=345) from Indian organizations, this study uses structural equation modeling to confirm the differential mediating mechanism for OC dimensions.

Findings
The results suggest that resilience can create a pathway for positive emotions and increase life satisfaction, which, in turn, can help an employee to stick to the organization. Notably, findings indicate that affect balance fully mediates the linkages between resilience and affective commitment, whereas life satisfaction fully mediates the relationship between resilience and continuance commitment.

Practical implications
Besides making useful contributions to the concerned literature, the findings also have useful messages for managers and organizations trying to develop a committed workforce by building employee resilience.

Originality/value
Although previous studies have supported the relationship between resilience and OC, to date, no study has analyzed the motivational and cognitive process through which resilience relates to each dimension of OC (i.e. affective, normative and continuance).
Internal audit effectiveness: operationalization and influencing factors
Authors: Turetken Oktay , Jethefer Stevens , Ozkan Baris 
Published: January 2020

Purpose
The purpose of this paper is to introduce a framework that presents how internal audit effectiveness can be operationalized and what factors are available to influence the effectiveness. Internal audits have become one of the key practices for organizations to control the adherence of their processes to standard procedures and regulations. The benefits of conducting internal audits are well acknowledged in the literature. However, it is difficult for organizations to assess the effectiveness of internal audits and to understand the factors that influence audit effectiveness.

Design/methodology/approach
A systematic literature review was conducted to identify relevant publications and collect and synthesize evidence on the operationalization of internal audit effectiveness and the factors that potentially influence the effectiveness of internal audits.

Findings
A thorough analysis of the relevant studies resulted in a comprehensive list of indicators used for the operationalization of audit effectiveness and a list of potentially influencing factors. The results of the systematic review are synthesized into a framework.

Research limitations/implications
The researchers should consider this study as a comprehensive source that offers pointers on the factors investigated in the literature and a basis for future research in this field to address the gaps that are identified.

Practical implications
Awareness about how the effectiveness of internal audits can be measured, and the factors that can potentially influence this effectiveness can help organizations to understand their current performance and ultimately improve it in the future.

Originality/value
The contributions of this study will help in better understanding the state of the research on internal audit effectiveness, including the influential factors, and gaps and opportunities for future research.
Dietary patterns in relation to major cardiovascular diseases risk factors
Authors: Roohafza Hamidreza , Feizi Awat , Amani Tirani Shahnaz , Sadeghi Masoumeh , Sarrafzadegan Nizal 
Published: January 2020

Purpose
The purpose of this study was to evaluate the association of empirically derived dietary patterns with hypertension and hyperlipidemia among a large sample of Iranian industrial employees.

Design/methodology/approach
This cross-sectional study was done under the framework of Epidemiological Survey of Chronic Diseases on Manufacturing Employees. Major dietary patterns were derived based on a validated short form of food frequency questionnaire (FFQ) using exploratory factor analysis. Self-administered validated questionnaires were used to collect data on socio-demographic and job-related variables of participants. Multivariable logistic regression was applied for association analyses.

Findings
Higher levels of Western dietary pattern increased significantly the risk of hypertension (odds ratio [OR] = 1.85, 95% CI [1.36-2.53], P trend <0.001) and hyperlipidemia (OR = 1.45, 95% CI [1.16-1.81], p = 0.001) even after controlling for confounding variables. The traditional dietary pattern was marginally associated with a significant increase in risk of hyperlipidemia ( = 1.14, 95% CI [0.92-1.41], p = 0.084) in the fully adjusted model. However, higher levels of healthy dietary pattern were significantly associated with a decreased risk of hyperlipidemia in the final model (OR 0.80, 95% CI [0.64-0.90], p = 0.025).

Originality/value
To the authors’ knowledge, an association analysis between dietary patterns and major cardiovascular disease risk in workforce population over the world is scarce and has not yet been conducted among Iranian industrial employees. This study’s findings are especially relevant for the industrial workforce population because they are at high risk of other job-related risks that increase the CVD risk.
Implications of energy drink consumption for hepatic structural and functional changes: a review
Authors: Kutia Sergey , Kriventsov Maxim , Moroz Gennady , Gafarova Elvina , Trofimov Nazar 
Published: January 2020

Purpose
In the recent decades, energy drinks consumption has increased dramatically. Many researches found their adverse effects on the structure and function of organs and systems, with nervous and cardiovascular systems most studied. Liver is one of the priority target organs in case of beverages consumption. The purpose of this paper is to explore the effects of energy drink consumption on morphofunctional conditions of liver.

Design/methodology/approach
A search in PubMed, Web of Science, Scopus and eLIBRARY.ru databases was performed using relevant keywords.

Findings
Both clinical and experimental data concerning effects of energy drink use on structure and function of liver are summarized and systematized in this review. Most of them documented hepatotoxicity after prolonged over-consumption of energy drinks. Probable mechanisms of action of their basic ingredients (sugars, caffeine, taurine, D-glucuronolactone, vitamin B3) on morphology and functioning of liver as well as combined use of energy drinks with alcohol are described.

Originality value
This review paper represents evidential information about the negative impact of energy drink consumption on morphofunctional conditions of liver.
Energy dissipation characteristics of additively manufactured CNT/ABS nanocomposites
Authors: Gardea Frank , Cole Daniel P. , Glaz Bryan , Riddick Jaret C. 
Published: January 2020

PurposeThis study aims to discuss the effect of carbon nanotubes (CNTs) on the mechanical properties of acrylonitrile–butadiene–styrene (ABS) composites fabricated by additive manufacturing (AM). Insight into the energy-dissipation mechanisms introduced and/or enhanced by the addition of CNTs is presented in this study.Design/methodology/approachABS/CNT filaments were fabricated with different concentrations of CNTs. Using a fused deposition modeling approach, unidirectional specimens were printed using a MakerBot Replicator 2X (MakerBot Industries, Brooklyn, NY, USA). Specimens were tested under static and dynamic conditions, with the loading coinciding with the printing direction, to determine elastic modulus, strength and viscoelastic properties.FindingsA CNT reinforcing effect is evident in a 37 per cent increase in elastic modulus. Likewise, the strength of the composite increases by up to 30 per cent with an increase in weight fraction of CNTs. At low dynamic strain amplitudes (0.05 per cent), a correlation between dissipated strain energy of the butadiene phase and strength of the composite is found such that less dissipation, from constraint of the butadiene particles by the CNTs, leads to higher strength of the composite. At higher dynamic strains, the presence of a high concentration of CNT leads to increased energy dissipation, with a maximum measured value of 24 per cent higher loss factor compared to baseline specimens. Because the trend of the composite behavior is similar (with a higher absolute value) to that of neat ABS, this study’s results indicate that well-established polymer/CNT dissipation mechanisms (such as stick-slip) are not significant, but that the CNTs amplify the dissipation of the ABS matrix by formation of crazes through stress concentrations.Originality/valueThis study provides knowledge of the dissipation behavior in additively manufactured ABS/CNT composites and provides insight into the expansion to new printable materials for dynamics applications.
The state of corporate social responsibility practice in the construction sector
Authors: Olanipekun Ayokunle Olubunmi , Oshodi Olalekan Shamsideen , Darko Amos , Omotayo Temitope 
Published: January 2020

PurposeThe development of corporate social responsibility (CSR) in the construction sector is slow, thereby leaving many opportunities for further development. To enable operators in the construction sector to effectively capitalise on the opportunities to promote the development of CSR in the sector, this study employs the practice viewpoint to take the stock of CSR activities in the sector. The purpose of this paper is to reveal the state of CSR practice in the construction sector. The study also draws from the development of CSR in the manufacturing, mining and banking sectors to inform the state of CSR practice in the construction sector.Design/methodology/approachThis study carries out a systematic literature review of 56 journal publications that were published between the year 2000 and 2016. The deductive coding of the publications was done to identify four themes of CSR research that constitute the practice view of the state of CSR in the construction sector.FindingsThe implementation of CSR is the major emphasis in the state of CSR practice in the construction sector. The implementation of CSR is wrapped in the perception of operators about CSR potentials, dimensions of CSR implemented, strategies for implementation and the effects of the implemented CSR practices on performance. The sector characteristics and organisational structure are attributes for comparing the CSR practices between the construction sector and the manufacturing, mining and banking sectors.Originality/valueThis study provides a researchers’ view of the state of CSR in the construction sector. Additionally, the study draws from the development of CSR in the manufacturing, mining and banking sectors to inform the state of CSR practice in the construction sector.