bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of dementia on aged care service transitions in the last five years of life
Authors: Welberry Heidi J , Jorm Louisa R , Barbieri Sebastiano , Hsu Benjumin , Brodaty Henry 
Published: November 2020

Abstract

Objective
To investigate the impact of dementia on aged care service use at end-of-life.

Methods
Our retrospective data linkage study in New South Wales, Australia, used survey data from participants in the 45 and Up Study who died between July 2011–June 2014 linked to routinely collected administrative data for 2006–2014. We investigated movement between aged care “states” (No Services, Home Care including Home Support and Low-and High-Level Home Care and Residential Care) in the last five years of life. The dementia cohort comprised decedents with a dementia diagnosis recorded in hospital records, death certificates or who had claims for dementia-specific medicines prior to death (n = 2,230). The comparison cohort were decedents with no dementia diagnosis, matched 1:1 on age-at-death, sex, income and location.

Results
Compared to those without dementia, people with dementia were more likely to: use home care (67 versus 60%, P &lt; 0.001), enter residential care (72 versus 30%, P &lt; 0.001) and stay longer in residential care (median 17.9 versus 12.7 months, P &lt; 0.001). Five years before death, more people with dementia were within residential care (6 versus 4%; RR = 1.61, 95%CI = 1.23–2.10) and these rates diverged at the end-of-life (69 versus 28%, RR = 2.48, 95%CI = 2.30–2.66). Use of home-based care was higher among people with dementia five years from death (20 versus 17%; RR = 1.15, 95%CI = 1.02–1.30) but lower at end-of-life (13 versus 24%, RR = 0.55, 95%CI = 0.49–0.63).

Conclusion
Dementia-specific aged care trajectories were dominated by residential care. Home care use declined towards end-of-life for people with dementia and may not be meeting their needs.
Behavioral variation in natural contests: integrating plasticity and personality
Authors: Couchoux Charline , Garant Dany , Aubert Maxime , Clermont Jeanne , Réale Denis 
Published: November 2020

AbstractAnimals often interact aggressively when competing over limited resources. Aggressive decisions can be complex and may result from multiple sources of behavioral variation. The outcome of contests may be explained through contest theory and personality by considering conjointly plasticity and individual consistency. This integrative approach also allows investigating individual differences in responsiveness to environmental changes. Here, we observed multiple agonistic interactions occurring among eastern chipmunks (Tamias striatus) competing for food resources supplied at different distances from their burrows. Using an individual reaction norm approach, we found that the probability of winning a contest depended on an individual’s intrinsic characteristics (mass and age but not sex) but was also adjusted to characteristics of its opponents. Winning a contest also depended on extrinsic environmental characteristics, such as distance to the contestants’ burrows, but not the order of arrival at the feeding patch. We found consistent individual differences in the probability of winning, potentially related to differences in aggressiveness and territoriality. We also found that individuals differed in their plasticity level in response to changes in different characteristics of their social and physical environments. Plasticity, personality, and individual differences in responsiveness may thus all play a role in predicting contest outcome and in the evolution of animal contests.
Challenging the working time reduction and wages trade-off: a simulation for the Spanish economy
Authors: Cárdenas Luis , Villanueva Paloma 
Published: November 2020

Abstract
This paper analyzes the effect of working time reduction (WTR) on the Spanish economy. Using microdata from the Economically Active Population Survey (EAPS) and the Wage Structure Survey (WSS), we estimate the changes in employment, worked hours, wages and salaries, and the labour share driven by a 5-hour reduction of the ordinary work week in full-time contracts (from 40 hours to 35 hours), without a wage reduction. According to our results, this WTR would mean the liberation of private sector hours that are equivalent to 1.2 million full-time jobs. To calculate job creation, we consider the occupations and technical conditions of production (based on the European Working Conditions Survey). Consequently, had the WTR taken place in 2017, it would have created 560 thousand jobs, thus causing the unemployment rate to fall by 2.6 p.p. Moreover, women are found to be the group most affected by this measure. As for the effect on wages, these would have increased by 3.7%, implying a labour share increase of 2.1 p.p. Finally, we study the macroeconomic effects, through an extended version of the single-equations Bhaduri–Marglin model using quarterly data from 1995Q1 until 2017Q4. Our results show that a WTR of 5 hours leads to an increase of 1.4% in GDP.
Family, Community and Long-Term Socio-Economic Inequality: Evidence from Siblings and Youth Peers
Authors: Bingley Paul , Cappellari Lorenzo , Tatsiramos Konstantinos 
Published: November 2020

AbstractUsing administrative data for the population of Danish men and women, we develop an empirical model which accounts for the joint earnings dynamics of siblings and youth community peers. We provide the first decomposition of the sibling correlation of permanent earnings into family and community effects allowing for life-cycle dynamics and extending the analysis to consider other outcomes. We find that family is the most important factor influencing sibling correlations of earnings, education and unemployment. Community background matters for shaping the sibling correlation of earnings and unemployment early in the working life, but its importance quickly diminishes.
Discriminatory cardiac arrest care? Patients with low socioeconomic status receive delayed cardiopulmonary resuscitation and are less likely to survive an in-hospital cardiac arrest
Authors: Agerström Jens , Carlsson Magnus , Bremer Anders , Herlitz Johan , Israelsson Johan , Årestedt Kristofer 
Published: November 2020

Abstract

Aims
Individuals with low socioeconomic status (SES) face widespread prejudice in society. Whether SES disparities exist in treatment and survival following in-hospital cardiac arrest (IHCA) is unclear. The aim of the current retrospective registry study was to examine SES disparities in IHCA treatment and survival, assessing SES at the patient level, and adjusting for major demographic, clinical, and contextual factors.

Methods and results
In total, 24 217 IHCAs from the Swedish Register of Cardiopulmonary Resuscitation were analysed. Education and income constituted SES proxies. Controlling for age, gender, ethnicity, comorbidity, heart rhythm, aetiology, hospital, and year, primary analyses showed that high (vs. low) SES patients were significantly less likely to receive delayed cardiopulmonary resuscitation (CPR) (highly educated: OR = 0.89, and high income: OR = 0.98). Furthermore, patients with high SES were significantly more likely to survive CPR (high income: OR = 1.02), to survive to hospital discharge with good neurological outcome (highly educated: OR = 1.27; high income: OR = 1.06), and to survive to 30 days (highly educated: OR = 1.21; and high income: OR = 1.05). Secondary analyses showed that patients with high SES were also significantly more likely to receive prophylactic heart rhythm monitoring (highly educated: OR = 1.16; high income: OR = 1.02), and this seems to partially explain the observed SES differences in CPR delay.

Conclusion
There are clear SES differences in IHCA treatment and survival, even when controlling for major sociodemographic, clinical, and contextual factors. This suggests that patients with low SES could be subject to discrimination when suffering IHCA.
Authorized Generics and Biosimilars as Part of Drug Life Cycle Management
Authors: Kunst Manuel , Kaufmann Ulrike 
Published: November 2020

Abstract
Nowadays there is no longer a clear distinction between innovative pharmaceutical companies and generic and biosimilar manufacturers. The latter seek patent protection for new formulations or medical uses of known pharmaceuticals, and originators have responded by building their own generic divisions. Through them, innovative pharmaceutical companies are able to launch their own generics or biosimilars to cushion the loss of revenues after the expiry of blockbuster patents. In particular, in recent years so-called authorized generics and biosimilars have received increased attention as part of patent expiry strategies.
Water column structure defines vertical habitat of twelve pelagic predators in the South Atlantic
Authors: Madigan Daniel J , Richardson Andrew J , Carlisle Aaron B , Weber Sam B , Brown Judith , Hussey Nigel E 
Published: November 2020

Abstract
Quantifying vertical distributions of pelagic predators elucidates pelagic ecosystem structure and informs fisheries management. In the tropical South Atlantic Ocean, the recently designated large-scale marine protected area around Ascension Island hosts diverse pelagic predators for which basin-specific vertical habitat information is minimal or absent. We used pop-up satellite archival tags to analyse vertical habitat use in 12 species (bigeye tuna Thunnus obesus, blue marlin Makaira nigricans, blue shark Prionace glauca, dolphinfish Coryphaena hippurus, Galapagos shark Carcharhinus galapagensis, oceanic whitetip Carcharhinus longimanus, sailfish Istiophorus albicans, silky shark Carcharhinus falciformis, swordfish Xiphias gladius, tiger shark Galeocerdo cuvier, wahoo Acanthocybium solandri, and yellowfin tuna Thunnus albacares) and quantify parameters (temperature, dissolved oxygen, diel cycles, lunar phase) known to constrain vertical movements. Predator depth distributions varied widely, and classification trees grouped predators into four clades: (i) primarily epipelagic; (ii) partial thermocline use; (iii) oscillatory diving with thermocline/sub-thermocline use; and (iv) extensive use of sub-thermocline waters. Vertical habitat differences were linked to thermal physiology and foraging ecology, and species-specific physical constraints from other ocean basins were largely conserved in the South Atlantic. Water column features defined species-specific depth distributions, which can inform fisheries practices and bycatch risk assessments and population estimates.
On Transitive Action on Quiver Varieties
Authors: Chen Xiaojun , Eshmatov Farkhod , Eshmatov Alimjon , Tikaradze Akaki 
Published: November 2020

Abstract
Associated with each finite subgroup $\Gamma $ of ${\textrm {SL}}_2({\mathbb {C}})$ there is a family of noncommutative algebras $O_\tau (\Gamma )$ quantizing ${\mathbb {C}}^2/\!\!/\Gamma $. Let $G_\Gamma $ be the group of $\Gamma $-equivariant automorphisms of $O_\tau $. In [16], one of the authors defined and studied a natural action of $G_\Gamma $ on certain quiver varieties associated with $\Gamma $. He established a $G_\Gamma $-equivariant bijective correspondence between quiver varieties and the space of isomorphism classes of $O_\tau $-ideals. In this paper we prove that the action of $G_\Gamma $ on the quiver variety is transitive when $\Gamma $ is a cyclic group. This generalizes an earlier result due to Berest and Wilson who showed the transitivity of the automorphism group of the 1st Weyl algebra on the Calogero–Moser spaces. Our result has two important implications. First, it confirms the Bocklandt–Le Bruyn conjecture for cyclic quiver varieties. Second, it will be used to give a complete classification of algebras Morita equivalent to $O_\tau (\Gamma ),$ thus answering the question of Hodges. At the end of the introduction we explain why the result of this paper does not extend when $\Gamma $ is not cyclic.
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence
Authors: Digitale Jean C , Callaway Perri C , Martin Maureen , Nelson George , Viard Mathias , Rek John , Arinaitwe Emmanuel , Dorsey Grant , Kamya Moses , Carrington Mary , Rodriguez-Barraquer Isabel , Feeney Margaret E 
Published: November 2020

AbstractKiller cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner. Individuals homozygous for HLA-C2, which mediates strong inhibition via KIR2DL1, had the highest odds of parasitemia, HLA-C1/C2 heterozygotes had intermediate odds, and individuals homozygous for HLA-C1, which mediates weaker inhibition through KIR2DL2/3, had the lowest odds of parasitemia. In addition, higher surface expression of HLA-C, the ligand for inhibitory KIR2DL1/2/3, was associated with a higher likelihood of parasitemia. Together these data indicate that stronger KIR-mediated inhibition confers a higher risk of P. falciparum parasitemia and suggest that KIR-expressing effector cells play a role in mediating antiparasite immunity.
Calling in the Heavyweights: Why the World Bank Established the Carbon Pricing Leadership Coalition, and What It Might Achieve
Authors: Wettestad Jørgen , Gulbrandsen Lars H , Andresen Steinar 
Published: November 2020

Abstract
The initial key international climate policy and carbon market hub was the United Nations Framework Convention on Climate Change. Over time several international organizations and networks have been added to the “international carbon market web,” such as several World Bank (WB) initiatives. As to the latter, the Carbon Pricing Leadership Coalition (CPLC) was launched in 2015. A key question then becomes: considering an increasingly dense international environment, why was the Coalition formed? Our analysis shows the importance of taking into account institutional pathways in the Bank itself and the character of previous WB-internal initiatives. However, it is particularly important to note interaction with a strong external pull, stemming both from more “systemic” developments such as the collapse of the Clean Development Mechanism system and the explicit request for new initiatives from key actors, such as UN General Secretary Ban-Ki Moon. We suggest seeing entrepreneurship from the bureaucracies of international organizations as conditional on member-state behavior or a conducive institutional environment (or both). We also discuss main prospects ahead, both for the Coalition and the more general organizational set-up in this issue-area. Here we draw attention to the role of the WB as an international “heavyweight” and CPLC and Bank meetings held back to back.
Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii
Authors: Cebrero-Cangueiro T , Nordmann P , Carretero-Ledesma M , Pachón J , Pachón-Ibáñez M E 
Published: November 2020

Abstract

Objectives
To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.

Methods
An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. baumannii clinical isolates. The efficacies of the carbapenems in monotherapy and in combination were tested.

Results
Meropenem was better than imipenem in mice infected with either of the carbapenem-resistant A. baumannii (CRAb) strains. The combination of meropenem plus imipenem significantly improved the clearance of CRAbs from spleen compared with non-treated groups. The carbapenem-containing combination was better than imipenem for treating mice infected with both carbapenemase producers. In blood, the carbapenem combination significantly decreased the bacterial load of the OXA-23 producers compared with imipenem or meropenem used in monotherapy.

Conclusions
These results suggest that dual carbapenem combination could be an option for the treatment of infections due to carbapenemase-producing A. baumannii such as OXA-23 and OXA-58 producers.
Hypermobility, age 40 years or older and BMI &gt;30 kg m−2 increase the risk of complications following peri-acetabular osteotomy
Authors: Salih Saif , Groen Floris , Hossein Fahad , Witt Johan 
Published: November 2020

Abstract
The peri-acetabular osteotomy (PAO) is a powerful surgical procedure for correcting symptomatic acetabular dysplasia, but it carries the potential for significant surgical complications. This study aims to determine the complication profile of PAO in a series performed by an experienced single surgeon. This was as retrospective review of 223 hips in 200 patients (23 bilateral, 22 males and 201 females). Complication data were collected from notes and radiographic review and graded according to a modified Dindo–Clavien classification. Each hip could be recorded as having more than one complication. Mean age at surgery was 28.8 years (range 13-48), mean weight was 70.9 kg (range 45–115 kg). Diagnosis was dysplasia in 185 hips, retroversion in 25 and a combination in 13. Mean follow-up was 26 months. In all, 61.4% of hips (137) had no complications; 74.0% had no complications or a Grade I complication (one that did not change management); 52 hips (23%) required pharmaceutical interventions (Grade II complications). Six hips (2.7%) suffered a major complication (Grade III or IV) as a direct consequence of the PAO. There were no Grade V complications (death). Hypermobility (Beighton’s score of ≥6, Odds ratio (OR) 2.525 P = 0.041), age 40 years or older (OR 3.126 P = 0.012) and BMI &gt;30 (OR 2.506 P = 0.031), but not Tonnis grade (P = 0.193) increased the risk of more severe complications following a PAO. This single surgeon series from a high volume centre demonstrates that age 40 years or older and BMI &gt;30 kg m−2 and hypermobility increase the risk of more severe of complications.
Empirically Derived Profiles of Health-Related Quality of Life in Youth and Young Adults with Sickle Cell Disease
Authors: Keenan Mary E , Loew Megan , Berlin Kristoffer S , Hodges Jason , Alberts Nicole M , Hankins Jane S , Porter Jerlym S 
Published: November 2020

Abstract

Objective
Determining how the health-related quality of life (HRQOL) is impacted by living with Sickle Cell Disease (SCD) can inform psychosocial interventions. The purpose of the present study is to determine if demographic and treatment variables predict membership into empirically derived subgroups of HRQOL among youth and young adults with SCD.

Methods
Three hundred and seven youth and young adults with SCD (mean 17.63 years ± 3.74 years, 50.5% female) completed the Pediatric Quality of Life InventoryTM Sickle Cell Disease Module. Latent profile analysis examined subgroups/classes of HRQOL and relationships with demographic and treatment variables.

Results
Three distinct classes emerged: High HRQOL (34% of the sample), Moderate HRQOL (44% of the sample), and Low HRQOL (22% of the sample). Being female was associated with increased odds of being in the moderate or low groups. Living with more severe SCD (genotypes HbSS and HbSβ0 thalassemia) was associated with increased odds of being in the Low HRQOL group. Treatment with chronic red blood cell transfusion therapy was associated with increased odds of being in the High HRQOL group. Older age predicted a small increase in the odds of being in the Low versus High HRQOL group.

Conclusions
The present study adds to the literature on HRQOL in SCD by exploring person-centered, empirically derived groups of HRQOL. Identification of demographic and treatment factors that predict membership into those groups within a large sample assists in tailoring needed psychosocial interventions for youth with SCD.
MOBSTER – V. Discovery of a magnetic companion star to the magnetic β Cep pulsator HD 156424
Authors: Shultz M E , Rivinius Th , Wade G A , Kochukhov O , Alecian E , David-Uraz A , Sikora J 
Published: November 2020

ABSTRACT
HD 156424 (B2 V) is a little-studied magnetic hot star in the Sco OB4 association, previously noted to display both high-frequency radial velocity (RV) variability and magnetospheric H α emission. We have analysed the Transiting Exoplanet Survery Satellite (TESS) light curve, and find that it is a β Cep pulsator with 11 detectable frequencies, 4 of which are independent p-modes. The strongest frequency is also detectable in RVs from ground-based high-resolution spectroscopy. RVs also show a long-term variation, suggestive of orbital motion with a period of ∼years; significant differences in the frequencies determined from TESS and RV data sets are consistent with a light-time effect from orbital motion. Close examination of the star’s spectrum reveals the presence of a spectroscopic companion, however, as its RV is not variable it cannot be responsible for the orbital motion and we therefore infer that the system is a hierarchical triple with a so-far undetected third star. Reanalysis of least-squares deconvolution profiles from ESPaDOnS and HARPSpol spectropolarimetry reveals the surprising presence of a strong magnetic field in the companion star, with 〈Bz〉 about +1.5 kG as compared to 〈Bz〉 ∼−0.8 kG for the primary. HD 156424 is thus the second hot binary with two magnetic stars. We are unable to identify a rotational period for HD 156424A. The magnetospheric H α emission appears to originate around HD 156424B. Using H α, as well as other variable spectral lines, we determine a period of about 0.52 d, making HD 156424B one of the most rapidly rotating magnetic hot stars.
Temperature inversions on hot super-Earths: the case of CN in nitrogen-rich atmospheres
Authors: Zilinskas Mantas , Miguel Yamila , Lyu Yipeng , Bax Morris 
Published: November 2020

ABSTRACT
We show that in extremely irradiated atmospheres of hot super-Earths shortwave absorption of CN can cause strong temperature inversions. We base this study on previous observations of 55 Cancri e, which lead us to believe that ultrashort-period super-Earths can sustain volatile atmospheres, rich in nitrogen and/or carbon. We compute our model atmospheres in a radiative-convective equilibrium for a variety of nitrogen-rich cases and orbital parameters. We demonstrate the effects caused by thermal inversions on the chemistry and compute low-resolution synthetic emission spectra for a range of 0.5–28 $\rm{\mu m}$. Our results indicate that due to shortwave absorption of CN, atmospheres with temperatures above 2000 K and C/O ≥ 1.0 are prone to thermal inversions. CN is one of the few molecules that is extremely stable at large temperatures occurring on the dayside of short-period super-Earths. The emission spectrum of such atmospheres will differ substantially from non-inverted cases. In the case of inversions, absorption features become inverted, showing higher than expected flux. We propose that inversions in hot atmospheres should be the expected norm. Hot super-Earths are some of the most extreme natural laboratories for testing predictions of atmospheric chemistry and structure. They are frequently occurring, bright in emission and have short orbital periods. All these factors make them perfect candidates to be observed with JWST and ARIEL missions.