bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Influence of Lateral Conductivity Contrasts on the Storm Time Behavior of the Ground Electric Field in the Eastern United States
Authors: Marshalko Elena , Kruglyakov Mikhail , Kuvshinov Alexey , Murphy Benjamin S. , Rastätter Lutz , Ngwira Chigomezyo , Pulkkinen Antti 
Published: February 2020

AbstractThe intensification of the fluctuating geomagnetic field during space weather events leads to generation of a strong electric field in the conducting earth, which drives geomagnetically induced currents (GICs) in grounded technological systems. GICs can severely affect the functioning of such infrastructure. The ability to realistically model the ground electric field (GEF) is important for understanding the space weather impact on technological systems. We present the results of three‐dimensional (3‐D) modeling of the GEF for the eastern United States during a geomagnetic storm of March 2015. The external source responsible for the storm is constructed using a 3‐D magnetohydrodynamic (MHD) simulation of near‐Earth space. We explore effects from conductivity contrasts for various conductivity models of the region, including a 3‐D model obtained from inversion of EarthScope magnetotelluric data. As expected, the GEF in the region is subject to a strong coastal effect. Remarkably, effects from landmass conductivity inhomogeneities are comparable to the coastal effect. These inhomogeneities significantly affect the integrated GEF. This result is of special importance since the computation of GICs relies on integrals of the GEF (voltages), but not on the GEF itself. Finally, we compare the GEF induced by a laterally varying (MHD) source with that calculated using the plane wave approximation and show that the difference is perceptible even in the regions that are commonly considered to be negligibly affected by lateral nonuniformity of the source. Overall, the difference increases toward the north of the model where effects from laterally variable high‐latitude external currents become substantial.
Impact of Hurricane Maria on Beach Erosion in Puerto Rico: Remote Sensing and Causal Inference
Authors: Pérez Valentín Jaynise M. , Müller Marc F. 
Published: February 2020

AbstractBeach erosion due to large storms critically affects coastal vulnerability, but is challenging to monitor and quantify. Attributing erosion to a specific storm requires a reliable counterfactual scenario: hypothetical beach conditions, absent the storm. Calibrating models to construct counterfactuals requires numerous observations that are rarely available. Storm paths are unpredictable, making long‐term instrumentation of specific beaches costly. Optical remote sensing is hampered by persistent cloud cover. We use Sentinel‐1 satellite radar imagery to monitor shoreline changes through clouds and propose regression discontinuity as a strategy to estimate the causal effect of large storms on beach erosion. Applied to 75 beaches across Puerto Rico, the approach detects shoreline changes with a root‐mean‐square error comparable to the resolution of the imagery. Hurricane Maria caused an erosion of 3 to 5 m along its path, up to 40 m at particular beaches. Results reveal strong local disparities that are consistent with simulated nearshore hydrodynamic conditions.
Node-Level Resilience Loss in Dynamic Complex Networks
Authors: Moutsinas Giannis , Guo Weisi 
Published: February 2020

AbstractIn an increasingly connected world, the resilience of networked dynamical systems is important in the fields of ecology, economics, critical infrastructures, and organizational behaviour. Whilst we understand small-scale resilience well, our understanding of large-scale networked resilience is limited. Recent research in predicting the effective network-level resilience pattern has advanced our understanding of the coupling relationship between topology and dynamics. However, a method to estimate the resilience of an individual node within an arbitrarily large complex network governed by non-linear dynamics is still lacking. Here, we develop a sequential mean-field approach and show that after 1-3 steps of estimation, the node-level resilience function can be represented with up to 98% accuracy. This new understanding compresses the higher dimensional relationship into a one-dimensional dynamic for tractable understanding, mapping the relationship between local dynamics and the statistical properties of network topology. By applying this framework to case studies in ecology and biology, we are able to not only understand the general resilience pattern of the network, but also identify the nodes at the greatest risk of failure and predict the impact of perturbations. These findings not only shed new light on the causes of resilience loss from cascade effects in networked systems, but the identification capability could also be used to prioritize protection, quantify risk, and inform the design of new system architectures.
Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population
Authors: Huang Yu-Hua , Chang Kuo-Hsuan , Lee Yun-Shien , Chen Chiung-Mei , Chen Yi-Chun 
Published: February 2020

AbstractAlcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) encode essential alcohol-metabolizing enzymes. While alcohol use is associated with spontaneously deep intracerebral haemorrhage (SDICH), particularly in males, the activities and genetic variants of ADH and ALDH may affect SDICH development. This case-control study was conducted to identify the interaction of alcohol use and SDICH with five single-nucleotide polymorphisms (SNPs): ADH1B rs1229984, ADH1C rs2241894, ALDH2 rs671, ALDH2 rs886205, and ALDH2 rs4648328. We enrolled 208 patients with SDICH and 244 healthy controls in a Taiwanese population. ALDH2 rs671 was significantly associated with SDICH in the dominant (P < 0.001) and additive models (P = 0.007). ALDH2 rs4648328 was borderline significantly associated with SDICH in the recessive (P = 0.024) or additive models (P = 0.030). In alcohol-using patients, the ALDH2 rs671 GG genotype was associated with SDICH risk compared to the GA+AA genotype (P = 0.010). ADH1B rs1229984, ADH1C rs2241894, and ALDH2 rs886205 did not demonstrate association with SDICH. Thus, the ALDH2 rs671 GG genotype is a risk factor for SDICH. Because the genetic distributions of ALDH2 rs671 exhibited strong ethnic heterogeneity, further studies in different populations are needed to validate these findings.
Theory of Motivated Information Management: A Meta-Analytic Review
Authors: Kuang Kai , Wilson Steven R 
Published: February 2020

Abstract
The theory of motivated information management ([TMIM]; Afifi & Weiner, 2004) was proposed to explicate the processes through which uncertainty motivates information management. Over the past 15 years, the theory has been tested and applied to a wide range of topics and contexts. The current study meta-analyzes 33 studies from 31 articles that have empirically tested predictions from TMIM. Potential moderating effects of age, issue importance, and study design were also examined. Results, in general, provide support for bivariate associations proposed by TMIM, although these associations are heterogeneous and moderated by the average age of the sample and study design. A path model testing TMIM associations found good model fit after some modifications. Findings highlight the utility of TMIM as a theoretical framework (e.g., proposed paths operate as predicted), but also suggest changes that might better explain the range of ways in which uncertainty motivates information management.
2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOME): A Harmful Hallucinogen Review
Authors: Kamińska Katarzyna , Świt Paweł , Malek Kamilla 
Published: February 2020

Abstract
NBOMes are N-benzylmethoxy derivatives of the 2C family compounds with N-2-methoxybenzyl moiety substituted by the methoxy group at the 2- and 5-position and the halogen group at the 4-position of the phenyl ring. These substances are a new class of potent serotonin 5-HT2A receptor agonist hallucinogens with potential harmful effects. The substitution with halogen of the already psychoactive phenethylamine produces a derivative (2C-I) with increased hallucinogenic effects. This class of hallucinogens has chemical structures very similar to natural hallucinogenic alkaloid mescaline and these are sold mainly via internet as a ‘legal’ alternative to other hallucinogenic drug-lysergic acid diethylamide (LSD). 25I-NBOMe is the first synthesized and one of the most common compound from NBOMes. Knowledge of pharmacological properties of 25I-NBOMe is very limited so far. There are only a few in vivo and in vitro so far published studies. The behavioral experiments are mainly related with the hallucinogenic effect of 25I-NBOMe while the in vitro studies concerning mainly the affinity for 5-HT2A receptors. The 25I-NBOMe Critical Review 2016 reported 51 non-fatal intoxications and 21 deaths associated with 25I-NBOMe across Europe. Case reports describe various toxic effects of 25I-NBOMe usage including tachycardia, hypertension, hallucinations, rhabdomyolysis, acute kidney injury and death. The growing number of fatal and non-fatal intoxication cases indicates that 25I-NBOMe should be considered as a serious danger to public health. This review aims to present the current state of knowledge on pharmacological effects and chemical properties of 25I-NBOMe and to describe reported clinical cases and analytical methods available for identification of this agent in biological material.
Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent
Authors: Williams Ashlee E , Watt James , Robertson Larry W , Gadupudi Gopi , Osborn Michele L , Soares Michael J , Iqbal Khursheed , Pedersen Kim B , Shankar Kartik , Littleton Shana , Maimone Cole , Eti Nazmin A , Suva Larry J , Ronis Martin J J 
Published: February 2020

AbstractEpidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via intraperitoneal injection. Animals were sacrificed after 4 weeks. Bone length was measured; bone morphology was assessed by microcomputed tomography and dynamic histomorphometry. Reduced bone length was the only genotype-specific effect and only observed in males (p &lt; .05). WT rats exposed to PCB 126 had reduced serum calcium, and smaller bones with reduced tibial length, cortical area, and medullary area relative to vehicle controls (p &lt; .05). Reduced bone formation rate observed in dynamic histomorphometry was consistent with inhibition of endosteal and periosteal bone growth. The effects of PCB 126 were abolished in AhR −/− rats. Gene expression in bone marrow and shaft were assessed by RNA sequencing. Approximately 75% of the PCB-regulated genes appeared AhR dependent with 89 genes significantly (p &lt; .05) regulated by both PCB 126 and knockout of the AhR gene. Novel targets significantly induced by PCB 126 included Indian hedgehog (Ihh) and connective tissue growth factor (Ctgf/Ccn2), which regulate chondrocyte proliferation and differentiation in the bone growth plate and cell-matrix interactions. These data suggest the toxic effects of PCB 126 on bone are mediated by AhR, which has direct effects on the growth plate and indirect actions related to endocrine disruption. These studies clarify important mechanisms underlying skeletal toxicity of dioxin-like PCBs and highlight potential therapeutic targets.
Evaluating the Utility of Routine Imaging in Squamous Cell Carcinoma of the Nail Unit
Authors: Clark Melanie A. , Filitis Dan , Samie Faramarz H. , Piliang Melissa , Knackstedt Thomas J. 
Published: February 2020

BACKGROUND
Squamous cell carcinoma (SCC) is the most common malignant tumor of the nail unit. No guidelines currently exist regarding the role of imaging in this specific location.

OBJECTIVE
To investigate the utility of routine imaging in SCC of the nail apparatus.

METHODS
A multi-institutional retrospective review of patients treated for nail unit SCC was performed. Data were collected on patient characteristics, tumor qualities, treatment, and radiographic imaging. A change in treatment was defined as more aggressive treatment (amputation) rather than local excision or Mohs micrographic surgery (MMS).

RESULTS
One hundred seven patients with nail unit SCC were identified. Approximately 44/107 (41.1%) of patients were imaged and 63/107 (58.9%) were not. Mohs micrographic surgery was the most common primary treatment (66.4%). Mohs micrographic surgery was more commonly performed in nonimaged patients, and amputation was more commonly performed in imaged patients (p < .001). Bony changes were identified in 13/44 (29.5%) of imaged patients. In 8/44 (18.2%), imaging findings caused a change in treatment. In 99/107 (92.5%) of the cohort, imaging was either not performed or did not change management.

CONCLUSION
In select cases, imaging may help guide patient management. Sufficient evidence does not yet exist to support routine imaging for patients with nail unit SCC.
Evidence-based Nasal Analysis for Rhinoplasty: The 10-7-5 Method
Authors: Brito Íris M. , Avashia Yash , Rohrich Rod J. 
Published: February 2020

Summary:
Rhinoplasty is one of the top 5 aesthetic surgical procedures performed in plastic surgery. A methodical evaluation based on solid and up-to-date scientific evidence in different key areas of nasal and facial analysis is presented, the 10-7-5 method. This represents the most important preoperative step for a successful rhinoplasty. The 10-7-5 method for nasal analysis is a useful instrument that provides the rhinoplasty surgeon a deep comprehension of nasal anatomy. Understanding the nasal structures’ main relationships and consequences of each surgical maneuver on nasal framework assists on establishing the appropriate surgical goals for each patient, both in primary and secondary rhinoplasty cases. This systematic analysis of patient’s frontal, lateral, and basal nasal views provides a background to identify changes to ideal aesthetic proportions and how to surgically restore them while maintaining gender and ethnic congruency.
A Severe Adverse Effect of Atomoxetine: Hypertensive Crisis
Authors: Guldiken Gokce , Karayagmurlu Ali 
Published: February 2020

Abstract
Atomoxetine, a selective norepinephrine (noradrenaline) reuptake inhibitor, is an effective medication in attention-deficit hyperactivity disorder with a generally well-tolerated adverse effect profile. However, unusual side effects may occur during treatment. Here we report a case of hypertensive crisis in an 8-year-old male patient with autism spectrum disorder and attention-deficit hyperactivity disorder receiving atomoxetine treatment. We plan to discuss the clinical picture of the subject and importance of close monitoring during atomoxetine treatment.
The association between cancer and spousal rate of memory decline: a negative control study to evaluate (unmeasured) social confounding of the cancer-memory relationship
Authors: Ospina-Romero Monica , Brenowitz Willa D. , Glymour M. Maria , Mayeda Elizabeth R. , Graff Rebecca E. , Witte John S. , Ackley Sarah , Lu Kun Ping , Kobayashi Lindsay C. 
Published: February 2020

AbstractCancer diagnoses are associated with better long-term memory in older adults, possibly reflecting a range of social confounders that increase cancer risk but improve memory. We used spouse’s memory as a negative control outcome to evaluate this possible confounding, since spouses share social characteristics and environments, and individuals’ cancers are unlikely to cause better memory among their spouses. We estimated the association of an individual’s incident cancer diagnosis (exposure) with their own (primary outcome) and their spouse’s (negative control outcome) memory decline in 3,601 couples from 1998-2014 in the Health and Retirement Study, using linear mixed-effects models. Incident cancer predicted better long-term memory for the diagnosed individual. We observed no association between an individual’s cancer diagnosis and rate of spousal memory decline. This negative control study suggests that the inverse association between incident cancer and rate of memory decline is unlikely to be attributable to social/behavioral factors shared between spouses.
Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection
Authors: Ren Xiaoshuai , Liu Yan , Chen Hongtao , Liu Wei , Guo Zhaowang , Zhang Yaqin , Chen Chaoqun , Zhou Jianhui , Xiao Qiang , Jiang Guanmin , Shan Hong 
Published: February 2020

SummaryBackgroundCoronavirus Disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global threat to public health. Aiming to construct an efficient screening pattern, we comprehensively evaluated the performances of RT-PCR and chest CT in diagnosing COVID-19.MethodsThe records including demographics, RT-PCR, and CT from 87 confirmed COVID-19 cases and 481 exclusion cases were collected. The diagnostic accuracy of the pharyngeal swab RT-PCR, CT, combination with the second pharyngeal swab RT-PCR or with CT were evaluated individually. Besides, all the stool RT-PCR results were plotted by time to explore the value of stool RT-PCR.FindingsCombination of RT-PCR and CT has the higher sensitivity (91.9%,79/86) than RT-PCR alone (78.2%,68/87) or CT alone (66.7%, 54 of 81) or combination of two RT-PCR tests (86.2%,75/87). There was good agreement between RT-PCR and CT (kappa-value, 0.430). In 34 COVID-19 cases with inconsistent results, 94.1% (n=32) are mild infection, 62.5% of which (20/32) showed positive RT-PCR. 46.7% (35/75) COVID-19 patients had at least one positive stool during the course. Two cases had positive stool earlier than the pharyngeal swabs. Importantly, one patient had consecutive positive stool but negative pharyngeal swabs.InterpretationCombination of RT-PCR and CT with the highest sensitivity is an optimal pattern to screen COVID-19. RT-PCR is superior to CT in diagnosing mild infections. Stool RT-PCR should be considered as an item for improving discovery rate and hospital discharge. This study shed light for optimizing scheme of screening and monitoring of SARS-CoV-2 infection.FundingThis work was supported by the National Natural Science Foundation of China (No. 81502104), National Program on Key Basic Research Project (No. 2018YFC0910600),the Nature Science Foundation of Guangdong Province, China (Grant No: 2017A030313771 and 2020A151501001) and the Young Teachers Nurturing Program of Sun Yat-Sen University (Grant No:17ykpy62)
Dominance patterns in dynamic environments
Authors: Devi Archana , Jain Kavita 
Published: February 2020

AbstractNatural environments are seldom static and therefore it is important to ask how a population adapts in a changing environment. We consider a finite, diploid population with intermediate dominance evolving in a periodically changing environment and study how the fixation probability of a rare mutant depends on its dominance coefficient and the rate of environmental change. We find that in slowly changing environments, the dominance patterns are the same as in the static environment, that is, if a mutant is beneficial (deleterious) when it arrives, it is more (less) likely to fix if it is dominant. But in fast changing environments, these patterns depend on the mutant’s fitness on arrival as well as that in the time-averaged environment. We find that in a rapidly varying environment that is neutral or deleterious on-average, an initially beneficial (deleterious) mutant that arises while selection is decreasing (increasing) has a fixation probability lower (higher) than that for a neutral mutant leading to a reversal in the standard dominance patterns. We also find that recurrent mutations decrease the phase lag between the environment and the allele frequency, irrespective of the level of dominance.
Microtubule Defect Involved in ‘Mitophagy Resistance’ Under Subacute Oxidative Stress - Potential Mechanism for Cellular Inflammation
Authors: Tamura Takahiko , Yasuda Nobuo , Shakuo Tomoharu , Kashiwagi Aki , Martyn Jeevendra A. J. , Yokoyama Masataka , Yasuhara Shingo 
Published: February 2020

AbstractIntroductionOxidative stress is considered an essential mechanism in ICU-acquired weakness. The roles of oxidative stress in autophagy/mitophagy dysfunction remains elusive. Microtubule serves as an essential guide rail for auto/mitophagosome trafficking required for proper maturation of auto/mitophagosomes in normal circumstances, and microtubules network formation is regulated by signal transduction mechanisms involving Akt, GSK3β, and the microtubule plus-end tracking molecule, EB1. We have investigated (1) whether oxidative stress affects this pathway, leading to the defective mitophagy response, and (2) whether trehalose, an auto/mitophagy modulator, can ameliorate these pathological conditions.MethodsBy stably transfecting markers for auto/mitophagy or MT synthesis, we have established a few new C2C12 myocyte cell lines, expressing, GFP-LC3, EB1-GFP, and/or tandem-fluorescence LC3 (tfLC3). To monitor microtubule network, the cells were stained by SiR-tubulin. The cells were cultured in the presence or absence of oxidative stress by hydrogen peroxide (H2O2) and treated with or without trehalose. The response of mitophagy parameters including vesicle motion and the maturation status was monitored by stimulating the cells with carbonyl cyanide m-chlorophenyl hydrazone (CCCP), an established mitophagy inducer, under a time-lapse confocal microscopy. Signal transduction mechanisms linking mitophagy to microtubule formation was analyzed by Western Blotting against Akt and GSK3β.ResultsCells under the oxidative stress, showed abolished MT network formation, decreased microtubule synthesis by EB1, and a decrease in CCCP-invoked response of mitophagosome motion, perturbed mitophagosome maturation, and increased superoxide production. Signal resistance of Akt/GSK3β pathway to mitophagic stimulation, was documented. Trehalose treatment reversed signal resistance, diminished MT synthesis, ameliorated the disturbed MT network, and improved maturation defects, suppressing the production of superoxide.ConclusionsOxidative stress decreases the response of mitophagy and abolishes microtubule network. Trehalose improves the synthetic ability of microtubule and normalized the disturbed microtubule network, resulting in the improvement of the perturbed mitophagosomes maturation under the oxidative stress.