bluuebunny/crossref_metadata_2025_split huggingface dataset:
NKX2-2 Mutation Causes Congenital Diabetes and Infantile Obesity With Paradoxical Glucose-Induced Ghrelin Secretion
Authors: Auerbach Adi , Cohen Amitay , Ofek Shlomai Noa , Weinberg-Shukron Ariella , Gulsuner Suleyman , King Mary-Claire , Hemi Rina , Levy-Lahad Ephrat , Abulibdeh Abdulsalam , Zangen David 
Published: August 2020

Abstract

Context
NKX2-2 is a crucial transcription factor that enables specific β-cell gene expression. Nkx2-2(–/–) mice manifest with severe neonatal diabetes and changes in β-cell progenitor fate into ghrelin-producing cells. In humans, recessive NKX2-2 gene mutations have been recently reported as a novel etiology for neonatal diabetes, with only 3 cases known worldwide. This study describes the genetic analysis, distinctive clinical features, the therapeutic challenges, and the unique pathophysiology causing neonatal diabetes in human NKX2-2 dysfunction.

Case Description
An infant with very low birth weight (VLBW) and severe neonatal diabetes (NDM) presented with severe obesity and developmental delay already at age 1 year. The challenge of achieving glycemic control in a VLBW infant was unexpectedly met by a regimen of 3 daily doses of long-acting insulin analogues. Sanger sequencing of known NDM genes (such as ABCC8 and EIF2AK3) was followed by whole-exome sequencing that revealed homozygosity of a pathogenic frameshift variant, c.356delG, p.P119fs64*, in the islet cells transcription factor, NKX2-2. To elucidate the cause for the severe obesity, an oral glucose tolerance test was conducted at age 3.5 years and revealed undetectable C-peptide levels with a paradoxically unexpected 30% increase in ghrelin levels.

Conclusion
Recessive NKX2-2 loss of function causes severe NDM associated with VLBW, childhood obesity, and developmental delay. The severe obesity phenotype is associated with postprandial paradoxical ghrelin secretion, which may be related to human β-cell fate change to ghrelin-secreting cells, recapitulating the finding in Nkx2-2(–/–) mice islet cells.
Triangular Expanded Hemiporphyrazines: Electronic Structures and Nanoscale Characterization of Their Adlayers on Au(111)
Authors: Bacilla Ana C C , Okada Yusuke , Yoshimoto Soichiro , Islyaikin Mikhail K , Koifman Oskar I , Kobayashi Nagao 
Published: August 2020

Abstract
Electronic structures and direct observation of adlayers on Au(111) of triangular expanded hemiporphyrazines that can be classified into azaporphyrinoids and which can trap three transition metal ions are reported. The electronic structure was examined by electronic absorption and magnetic circular dichroism (MCD) spectroscopies and interpreted in conjunction with molecular orbital (MO) calculations. Both metal-free and metallated compounds were 30 π-electron systems with n = 7 in 4n + 2 aromaticity. In addition, calculations of the anisotropy of the induced current density (ACID) and nucleus-independent chemical shift (NICS) were performed. The inner core region of the metal-free compound was weakly anti-aromatic or nonaromatic, but after metal insertion, this region increased aromatic character. The direct observation of adlayers of one of their cobalt and nickel complexes on Au(111) by scanning tunneling microscopy (STM) revealed that these three ions are arranged specifically in the shape of a triangle.
Incidental pulmonary embolism in CT scans of oncological patients with metastatic disease undergoing clinical trials: frequency and linkage with onset of disease progression (PE-PD association)
Authors: Lawson Philip , Raskin Stephen , Soffer Shelly , Marom Edith , Berger Raanan , Amitai Marianne Michal , Kharizman Tehila , Konen Eli , Klang Eyal 
Published: August 2020

Objectives: We aimed to analyze the association between the onsets of PE and of progressive disease (PD) in CT scans of oncological patients undergoing clinical trials. Methods: We retrospectively searched our oncological clinical trials database (1/2012 - 6/2017). We retrieved patients who underwent protocol baseline and follow-up CT scans. RECIST 1.1 categories of response were calculated for each scan at interpretation. The entire dataset was searched for reports with incidental PE. For patients with incidental PE, we collected all the scans conducted up to and including the scan with PE. For each scan, we retrieved the recorded RECIST 1.1 category. We excluded patients with PE at baseline. The frequency of incidental PE in oncological clinical trial patients was calculated. For patients with incidental PE, we evaluated the association between PE and PD. Results: During the study period, 1,070 patients underwent 3,818 CTs. The total number of follow-up months was 7,292 months. 18 patients developed incidental PE during follow-up. Thus, the frequency of incidental PE in oncological clinical trial patients was 3% per year of follow-up. Patients with incidental PE underwent 60 scans up to development of PE. Of 42 non-baseline scans, 6/6 (100%) PD showed PE, and 5/36 (13.9%) non-PD showed PE, making PE onset associated with PD onset (p < 0.001). Conclusion: In oncological clinical trials, the frequency of incidental PE is 3% per year of follow-up. The onset of incidental PE is linked to the onset of PD. Advances in knowledge: Incidental PE is associated with the onset of disease progression. Radiologists interpret oncological scans should be aware of the association between PE and PD.
Associations between genetic factors in individualization of visual perception and components of event-related potentials during assessment of emotional visual stimuli (scenes) with distinct second-order features
Authors: Ermakov Pavel N. , Vorobyeva Elena V. , Kovsh Ekaterina M. , Stoletniy Alexander S. , Dalgatov Magomed M. , Khakunova Fatimet P. , Bersirova Asya K. 
Published: August 2020

Background: The aim of this paper is to investigate the associations between polymorphisms in the BDNF, COMT, and HTR2A genes with peculiarity of visual perception. In particular, how the carriers of different genotypes of Indicated genes emotionally evaluating visual scenes with distinct second-order features (images modulated by contrast) and how corresponding process is reflected in event-related brain activity (ERP). Methods: The study involved students who underwent PCR-based genetic analysis with the release of BDNF, COMT, and HTR2A genotypes. Participants were asked to emotionally assesse the specific stimuli – visual scenes that were generated from contrast modulations. At the same time the EEG were recorded using a 128-electrodes system. The average frequency of responses and ERPs for different emotional evaluations (negative, neutral and positive) were analyzed. Results: The study showed the BDNF Val/Val polymorphism was associated with the increase in the P2 amplitude in the occipital regions compared to the Val/Met genotype regardless of emotional evaluation. The COMT Met/Met genotype polymorphism associated with the increase of N170 negativity in the occipital regions during evaluation task. The HTR2A polymorphism A/A associated with increase in the P1 amplitude when positive or negative assessment were chosen, and decrease of later positive peak when neutral evaluation was chosen. Conclusions: The results suggested that emotional evaluation and recognition of visual scenes with distinct second-order features, as well as various strategies for processing visual information, reflected in amplitude and latency of different ERPs components and associated with the different genotypes of BDNF, COMT, and HTR2A genes. The indicated interconnections can act as genetic basis of individualize the mechanisms of visual perception.
Sobre o que Ressoa e Faz Eco: Voz, Música e Lalíngua no Tratamento do Autismo
Authors: Viana Beatriz Alves , Brito Kemylle Mesquita , Furtado Luis Achilles Rodrigues 
Published: August 2020

Esse artigo aborda a articulação entre os conceitos psicanalíticos de lalíngua e de voz, pensados a partir da clínica com sujeitos autistas. Com base nas vinhetas clínicas retiradas da literatura e da experiência de trabalho em serviços de Saúde Mental, busca-se investigar de que formas essas noções teóricas se apresentam primordialmente no ato de escuta e como estas podem indicar uma direção de tratamento no autismo a partir da música. A musicalidade da voz materna, por meio de uma ressonância que não se prende ao sentido, transmite uma invocação ao infans para que este advenha como sujeito, produzindo marcas a serem lidas. É necessário que tal invocação, para que possa ressoar no sujeito, ocorra primeiramente no campo do Outro, como forma de apelo. No autismo, no entanto, há impasses quanto à alienação aos significantes provenientes do Outro, sentidos como invasivos. Com isso, constatou-se que a introdução da musicalidade na clínica com esses sujeitos surge como possibilidade de deixar suas marcas, por se tratar de um elemento que permite mediação no âmbito da enunciação.
MEMES, TECNOLOGIAS E EDUCAÇÃO: ‘CONVERSAS’ COM PROFESSORAS EM TEMPOS DE PANDEMIA
Authors: Sotero Elaine , Coutinho Brenda 
Published: August 2020

O foco do artigo é evidenciar a importância das tecnologias durante a pandemia do COVID-19, pois o uso dos artefatos tecnológicos está sendo cada vez mais útil nesse momento. Como o trabalho nos mostra, a tecnologia está sendo útil para que ocorram inúmeras interações, além de aulas online, criação de memes educativos, debates na internet etc.. Nesse momento, em que os encontros presenciais estão restringidos, e que as escolas estão fechadas, a importância da educação é cada vez mais evidenciada, pois a mesma vem sendo negligenciada por governos e por outros setores da nossa sociedade. Estamos vivenciando um momento político e social que nos permite dar uma resposta contrária à banalização que vem ocorrendo na educação, ou seja, este momento contraria a posição de que a escola pode ser descartável e substituível por classes em casa, por exemplo (homeschooling). Ao contrário disso, a educação escolar se faz necessária em todos os contextos históricos da sociedade, sejam eles quais forem. Como questões sócias de gravidade, como a pandemia em curso podem de transformar em questões curriculares, mediadas pelas tecnologias e pelas criações que elas permitem? Como serão o mundo e as escolas pós pandemia é algo que estamos gestando agora e que esse artigo busca refletir.
Relações entre o desenvolvimento infantil e as práticas pedagógicas representadas pelos professores de Educação Física
Authors: Santos Bruno Viviani dos , Campos Pedro Humberto Faria 
Published: August 2020

O presente estudo objetivou compreender e analisar as representações sociais do desenvolvimento infantil e discutir sua associação às práticas pedagógicas dos professores de Educação Física do Ensino Fundamental II. Para coleta de dados, foi aplicado um questionário com questões abertas a 103 professores, que deveriam explicar como o jogo de futsal, o jogo queimada e a dança contribuem para o desenvolvimento dos alunos nos aspectos afetivo, cognitivo e social. Os dados foram submetidos a uma análise do programa ALCESTE. Os resultados apontam para uma representação do desenvolvimento infantil na qual os sujeitos não estabelecem relações específicas entre as atividades apresentadas e as dimensões estudadas.
Enhanced saturable absorption in the laser-treated free-standing carbon nanotube films
Authors: Vanyukov V. V. , Mikheev K. G. , Nasibulin A. G. , Svirko Y. , Mikheev G. M. 
Published: August 2020

We demonstrate an increase of optical transmittance and saturable absorption of laser-treated free-standing single-walled carbon nanotube (SWNT) films. The combined acid and low-power non-destructive laser treatment ensures an enhancement of linear transmittance across the visible range and double-digit increase of the saturable absorption of femtosecond laser radiation at 795 nm. The saturable absorption coefficient and the ratio of saturable to non-saturable losses increase by 26% and 35%, correspondingly, while the saturation intensity decreases by 20% because of the treatment. Our analysis indicates that with the performed treatment one can significantly improve the nonlinear optical properties of free-standing SWNT-based ultrafast saturable absorbers.
Hybrid nano-scale Au with ITO structure for a high-performance near-infrared silicon-based photodetector with ultralow dark current
Authors: Li Xinxin , Deng Zhen , Li Jun , Li Yangfeng , Guo Linbao , Jiang Yang , Ma Ziguang , Wang Lu , Du Chunhua , Wang Ying , Meng Qingbo , Jia Haiqiang , Wang Wenxin , Liu Wuming , Chen Hong 
Published: August 2020

An internal photoemission-based silicon photodetector detects light below the silicon bandgap at room temperature and can exhibit spectrally broad behavior, making it potentially suited to meet the need for a near-infrared pure Si photodetector. In this work, the implementation of a thin Au insertion layer into an ITO/n-Si Schottky photodetector can profoundly affect the barrier height and significantly improve the device performance. By fabricating a nanoscale thin Au layer and an ITO electrode on a silicon substrate, we achieve a well-behaved ITO/Au/n-Si Schottky diode with a record dark current density of

3.7
×

10

−
7

A
/

cm

2

at

−
1

V

and a high rectification ratio of

1.5
×

10
8

at

±
1

V

. Furthermore, the responsivity has been obviously improved without sacrificing the dark current performance of the device by decreasing the Au thickness. Such a silicon-based photodetector with an enhanced performance could be a promising strategy for the realization of a monolithic integrated pure silicon photodetector in optical communication.
56 Gbps high-speed Ge electro-absorption modulator
Authors: Liu Zhi , Li Xiuli , Niu Chaoqun , Zheng Jun , Xue Chunlai , Zuo Yuhua , Cheng Buwen 
Published: August 2020

A high-speed evanescent-coupled Ge waveguide electro-absorption modulator (EAM) with simple fabrication processes was realized on a silicon-on-insulator platform with a 220 nm top Si layer. Selectively grown Ge with a triangle shape was directly used for Ge waveguides of the EAM. An asymmetric p-i-n junction was designed in the Ge waveguide to provide a strong electric field for Franz–Keldysh effect. The insertion loss of the Ge EAM was 6.2 dB at 1610 nm. The EAM showed the high electro-optic bandwidth of 36 GHz at

−
1

V

. Clear open 56 Gbps eye diagrams were observed at 1610 nm with a dynamic extinction ratio of 2.7 dB and dynamic power consumption of 45 fJ/bit for voltage swing of 3Vpp.
Epidemiology and the Impact of Therapies on the Outcome of COVID-19 in Patients With Inflammatory Bowel Disease
Authors: Papa Alfredo , Gasbarrini Antonio , Tursi Antonio 
Published: August 2020

INTRODUCTION:
It has been hypothesized that people suffering from inflammatory bowel disease (IBD) have an increased risk of coronavirus disease (COVID-19). However, it is not known whether immunosuppressive therapies exacerbate the COVID-19 outcome.

METHODS:
We reviewed data on the prevalence and clinical outcomes of COVID-19 in patients with IBD.

RESULTS:
COVID-19 prevalence in patients with IBD was comparable with that in the general population. Therapies using antitumor necrosis factor-α agents have been associated with better clinical outcomes.

DISCUSSION:
Management and treatments provided by gastroenterologists were effective in reducing COVID-19 risk. Antitumor necrosis factor-α agents seem to mitigate the course of COVID-19.
Efecto de remesas de trabajadores sobre reservas internacionales, crecimiento económico e índice de tipo de cambio real en Honduras
Authors: Santos-Munguía Rene Javier , Pérez Juan Miguel 
Published: August 2020

El estudio analiza el efecto de las remesas internacionales en Honduras sobre el índice mensual de actividad económica (IMAE) como una medida aproximada del crecimiento económico, las reservas internacionales y el índice de tipo de cambio efectivo real (Itcer). Con datos de series temporales con periodicidad mensual de diciembre de 2001 a diciembre de 2016, se formula un modelo del tipo vector autorregresivo (VAR) y se presentan resultados con figuras de la función impulso-respuesta (IFR). Los hallazgos muestran respuesta negativa del IMAE, Itcer y positiva de las reservas internacionales a mediano plazo.
Etnicidad, espacio y desarrollo humano en comunidades pobres urbanas: la comuna 6 en Cartagena de Indias, Colombia
Authors: Espinosa Espinosa Aaron Eduardo , Madero Jirado Maristella , Rodriguez Puello Gabriel Orlando , Díaz Canedo Luis Carlos 
Published: August 2020

Cartagena de Indias registra la mayor exclusión social entre las principales ciudades colombianas. Este artículo evalúa el nivel de desarrollo humano y los determinantes de la pobreza en la comuna 6, donde predomina la población afrocolombiana. Con el marco analítico de pobreza urbana, capacidades y estructura de oportunidades, y una base ad hoc para estimar un modelo probit como estrategia empírica, se elabora un perfil de pobreza diferenciado para esta extensa zona, con un enfoque espacial. Los resultados muestran que las variables laborales, étnicas –con evidencia concluyente a favor de blancos– y capital social explican las privaciones en esta comuna.
Um “Mapa Estratégico” para o Marketing
Authors: Pimenta da Gama António , Casaca Joaquim A. 
Published: August 2020

A avaliação da performance de marketing é um tema vital em muitas empresas. Nesse contexto, uma questão fundamental consiste em como conceptualizar e operacionalizar, com rigor, os instrumentos que conduzam a formas mais holísticas e equilibradas de avaliar a performance de marketing, não apenas para efeitos de monitorização e melhoria, mas também para comunicar estratégias. Infelizmente, apesar da existência de um número crescente de métricas individualiza­das, os estudos de modelização do fenómeno apresentados na literatura são escassos e a grande maioria não é suportada empiricamente. O presente trabalho desenvolve e testa um modelo inte­grado de avaliação da performance de marketing baseado na filosofia e nos princípios do Balan­ced Scorecard. Os dados foram obtidos através de um questionário respondido por 107 empresas portuguesas. Os resultados, analisados com base no método de equações estruturais, confirmam a robustez teórica do modelo e sugerem a sua viabilidade para avaliar a atuação de marketing. Nesse sentido, este estudo constitui um aprofundamento da temática em causa e fornece um instrumento destinado a orientar a seleção de um conjunto relevante de indicadores que auxilie as empresas a basearem análises de tipo avaliativo e decisões sobre alocação de recursos.
Desinformação e mensagens sobre a hidroxicloroquina no Twitter
Authors: Araujo Ronaldo , Oliveira Thaiane 
Published: August 2020

Introdução: A pandemia do novo coronavirus trouxe consigo um forte aliado responsável por tornar cada vez mais difícil o enfrentamento da doença, a desinformação científica. Opiniões negacionistas, teorias conspiratórias, oportunismo político são alguns exemplos de uso malicioso por trás da disseminação de informação sobre o vírus, seus efeitos, formas de tratamento e prevenção. Método: por meio de um estudo infodemiológico a pesquisa analisa o compartilhamento de informações no Twitter sobre a hidroxicloroquina, o medicamento que tem ganhado destaque quando se fala de um possível tratamento farmacológico da doença. Os dados foram coletados via Netlytic por meio do monitoramento da hashtag #hidroxicloroquinaja entre os dias 11 a 30 de maio e são analisados a partir da análise da rede de interação em torno do compartilhamento, compreensão dos termos frequentes e categorização das postagens. Resultados: Foram analisados 3.714 tweets e identificados 2.089 usuários, dos quais apenas 678 (32,4%) mantiveram algum tipo de conexão com outros usuários na rede. Os termos frequentes e sua distribuição indicam que a questão é protagonizada mais por aspectos políticos do que de saúde, com maior concentração de mensagens em poucos usuários e um grande número responsável por sua viralização. As categorias mais comuns foram “Ataque a agentes políticos” e “Descrença nas instituições epistêmicas”. Conclusão: No contexto estudado percebe-se que os valores da própria cultura científica, como reconhecimento e autoridade, vão ganhando novas camadas informacionais em disputa política em um momento no qual as instituições epistêmicas estão em declínio.
Pharmacological analysis of the effects of the neuropeptide Y antagonist BMS 193885 on the emotional, intraspecies behavior and reinforcing properties of ethanol in rats
Authors: Moskalyev Aleksander R. , Abrosimov Maxim E. , Vetlugin Eduard A. , Pshenichnaya Anna G. , Tissen Ilya Yu. , Ivankov Anatoliy S. , Bychkov Eugenii R. , Lebedev Andrei A. , Shabanov Petr D. 
Published: August 2020

Purpose. Our previously data on orexigenic peptides (orexin, ghrelin) showed antagonists of peptides receptors as correctors of the emotional-motivational and cognitive spheres. Currently, a close relationship between ghrelin and orexin with neuropetide Y has been shown in feeding and emotional behavior.
The aim of this work was to analyze the effect of the NPY antagonist Y1R BMS 193885 on emotional and intraspecies behavior, as well as on the reinforcing properties of ethanol in rats.
Methods. We used the open field test, elevated plus-maze, Porsolts forced swimming test, resident intruder test, conditional place preference (CPP). BMS 193885 1 mg/ml, 20 l intranasally did not cause an anxiogenic effect in the elevated plus-maze.
Results. In the Porsolts test, there was also no increase in the level of depression. Moreover, there was a significant decrease in the number and time of dives, as an indirect indicator of a decrease in the level of depression. At the same time, in the resident intruder test were decreased protective behavior, as an indicator of a decrease in the stress of intraspecific interaction in the absence of aggression. Moreover, local movements were increased in the open field test as an indicator of the animals activity impaired by fear. BMS 193885 had no effect on the expression of the CPP of ethanol.
Conclusion. Thus, it was previously shown that the BMS 193885 is a powerful, selective, brain-penetrating Y1 receptor antagonist, it reduces food intake and body weight in animal models of obesity both after acute and chronic administration. Our data indicate that the decrease in food intake is not associated with the level of anxiety, depression, or with a change in intraspecific interaction. It has been previously shown that NPY reduces alcohol consumption. Our data indicate that the Y1R antagonist of the neuropeptide Y BMS 193885 does not cause a change in the CPP of alcohol.
Medicaments and law (scientific review of the monograph of I.V. Ponkin and A.A. Ponkina «Pharmaceutical Law» (Moscow, GEOTAR-Media, 2017, 144 p.)).
Authors: Chelpanova Tatiana M. 
Published: August 2020

This publication is a review of the scientific monograph by I.V. Ponkina and A.A. Ponkina Pharmaceutical Law (Moscow: GEOTAR-Media, 2017).
The author of the review offers conclusions about the uniqueness of the research conducted for Russian legal science and about its high relevance in the field of legislative developments and accepting urgent measures on the fact of the threat of the COVID-19 pandemic.
The results of the research is the identification of a branch of pharmaceutical law in the Russia legal science and the possibility of legislative regulation of its unique legal elements in the field of production, use, quality control and safety of medicines, also in related branch of law, including intellectual property rights in the pharmaceutical field.