bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term heart-rate variability in healthy small and medium-sized dogs over a five-minute measuring period
Authors: Baisan Radu Andrei , Condurachi Eusebiu Ionuț , Vulpe Vasile 
Published: February 2020

Abstract

Introduction
Five-minute heart-rate variability (HRV) measurement is a useful tool for assessing the autonomic nervous system (ANS) balance in humans, but there are no studies on healthy dogs. The aim of the study was, therefore, to provide the reference ranges in small and medium-sized breeds for short-term HRV time and frequency domain (TFD) analyses.

Material and Methods
A total of 79 healthy dogs were included in the study between 2015 and 2019. Grouping by age with the breakpoint at six years and subgrouping by reproductive status and sex was imposed. All the dogs were included after physical and cardiological examinations and blood analyses. The TFD of HRV were analysed from a five-minute-long digital ECG recording after removal of non-sinus complexes.

Results
There were no statistically significant differences in any TFD parameters between age, reproductive status or sex groups. A mild increase in all time domain parameters and the high-frequency (HF) band was observed in older dogs, and the low frequency (LF):HF ratio decreased in these dogs. In males, the time domain parameters and HF band increased slightly.

Conclusion
The normal ranges for HRV derived from short-term ECG recording in the usual clinical environment now have proposed reference ranges. Our findings suggest that accommodation time, age, sex, or reproductive status do not influence the results derived from these recordings, indicating that this method is reliable for assessing the ANS function in small and medium-sized dog breeds.
The kinetics of γ-H2AX during radiotherapy of head and neck cancer potentially allow for prediction of severe mucositis
Authors: Kazmierska Joanna , Barczak Wojciech , Winiecki Tomasz , Łuczewski Łukasz , Marciniak Magdalena , Suchorska Wiktoria 
Published: February 2020

Abstract

Background
The aim of the study was to evaluate the changes in γ-H2AX expression in peripheral blood lymphocytes (PBL) according to severity of radiation-induced mucositis.

Patients and method
Fifty patients with head and neck cancer treated with radiotherapy (RT) or chemoradiation were included in the study. Blood samples were collected before treatment to measure baseline γ-H2AX levels. Second sample was taken 45 minutes after the first RT fraction and then once a week, 45 min after irradiation. In patients treated with chemoradiation the blood sample was taken the day after chemotherapy. Mucositis was evaluated once a week and reported according to CTCAE v4 and RTOG/EORTC scales. PBL were analyzed with flow cytometry and level of H2AX phosphorylation at every time point was evaluated.

Results
In 35 patients mild to moderate (grade 1–2) mucositis was observed and 15 patients developed severe (grade 3) mucositis. No cases of grade 4 mucositis were observed. The difference in baseline levels of γ-H2AX between groups with mild and severe mucositis was statistically insignificant (p = 0.25). The statistically significant difference in γ-H2AX level was observed in week 7 of treatment (p = 0.01). No significant differences in γ-H2AX level were found neither between group treated with concomitant chemoradiation or RT alone neither between groups with and without common comorbidities. In the analysis of the kinetics of γ-H2AX during treatment, a statistically significant difference (p = 0.0088) between groups with mild and severe mucositis was observed. After fourth week of treatment levels of γ-H2AX decreased significantly in the group with severe mucositis and increased in patients with mild side effects. The observed difference was not caused by the decrease in peripheral lymphocyte count, which was similar in both groups.

Conclusions
Presented results indicate that severity of radiation-induced mucositis does not correlate directly with γ-H2AX levels measured in vivo in PBL. Prediction of mucositis grade based on γ-H2AX level is not yet possible, either before treatment or early during treatment, but preliminary results, indicating significant differences in γ-H2AX kinetics between groups, encourage further studies.
Do Individual Risk Attitudes, Experience, and Organizational Culture Influence the Conservatism of Indonesian Auditors?
Authors: Maradona Agus Fredy 
Published: February 2020

This study examines the effects of individual risk attitudes, professional experiences, and organizational cultures on auditor conservatism in Indonesia. On the basis of a factorial survey involving 153 auditors in three major cities in Indonesia (Jakarta, Surabaya, and Denpasar), this study finds strong evidence that, compared with others, auditors with a lower tendency to take risks and those who have less professional experience tend to be more conservative when performing audit tasks. Nonetheless, this study does not find evidence of the influence of organizational culture on auditor conservatism. Overall, the findings of this study could be of interest to professional associations, regulatory bodies, and other policymakers in Indonesia and other countries as they attempt to constrain aggressive reporting through high-quality independent audits by public accountants in their jurisdictions.
Keywords: Auditor conservatism, risk attitude, experience, organisational culture, auditing standards
Disclosure of Risk Factors on Prospectus and Initial Public Offerings (IPO) Performance: Evidence from Indonesia
Authors: Kuswanto Randy 
Published: February 2020

The purpose of this study is to investigate how risk information disclosed in prospectus influences the initial returns of initial public offerings (IPOs) in Indonesia. This study collected 62 sample IPOs offered in the Indonesian Stock Exchange from 2017–2018. Ordinary least squares was performed to test the association between risk disclosure and initial returns. Results indicate that prospectus provides risk information associated with initial returns. Both qualitative and quantitative dimensions have a significant negative impact on the initial returns. It can be concluded that risk information has an important role in the underpricing phenomenon. The study has extended the available literature by investigating risk disclosure from a dual perspective. Moreover, qualitative and quantitative assessments both have a direct impact on the initial returns and must be considered in investment decision making.
Keywords: Risk, IPO, underpricing, initial returns
Analyzing and Formulating a Statutory General Anti-Avoidance Rule (GAAR) in Indonesia
Authors: Wijaya Suparna , Kusumaningtyas Dewi Sekarsari 
Published: February 2020

Dealing with the practice of tax avoidance in general, many countries have compiled and implemented their own general anti-avoidance rules (GAAR). This research aims to explore the potential of statutory GAAR in handling tax avoidance practices in Indonesia and SAAR formulas that are suitable for the Indonesian context. This qualitative research employed a case study approach. Results show that the application of SAAR and the principle of substance over form in Indonesia cannot yet be applied properly; thus GAAR is needed. It is expected that the implementation of statutory GAAR can accommodate the limitations of regulators in light of unknown and future tax avoidance schemes..
Keywords: Tax-avoidance, tax planning, specific anti avoidance rule (SAAR), international tax
Corporate Governance, Market Share, and Intellectual Capital Disclosure: Evidence from the Indonesian Agriculture and Mining Sectors
Authors: Hatane Saarce Elsye , Kuanda Elenne Stefanie , Cornelius Elizabeth , Tarigan Josua 
Published: February 2020

Using a sample of Indonesian agricultural and mining companies, this study aims to provide empirical evidence to prove the effects of auditor type, the board size, and audit committee on intellectual capital disclosure (ICD). The sample consisted of 18 agricultural and 28 mining companies, which were chosen using the content analysis method. The five-year observation period lasted from 2013 to 2017, resulting in 230 units of analysis. Data analysis employed a panel regression model with panel data testing. The study finds a positive impact of auditor type and audit committee on ICD as well as a negative influence of board size on ICD. The results conform to existing stakeholder and legitimacy theories.
Keywords: Intellectual capital disclosure; auditor type; board size; audit committee
The Impact of Internal Control and Individual Morals on Fraud: An Experimental Study
Authors: Efrizon Efrizon , Febrianto Rahmat , Kartika Rayna 
Published: February 2020

This study aims to obtain evidence to determine whether there are differences in the likelihood to commit fraud between individuals under the conditions of present and absent internal control and between individuals with high and low levels of individual morality. The study also aims to determine whether the interaction between individual morality and internal controls lead to fraud. Results show differences among individuals under the conditions of present or absent internal control to commit fraud. Moreover, there are differences among individuals who have high and low levels of individual morality to commit fraud. Finally, results reveal that the interaction between individual morality and internal controls lead to fraud.
Keywords: Fraud; internal control; individuals moral
Improving Patient-Pharmacist Encounters with Over-The-Counter Medications: A Mixed-Methods Pilot Study
Authors: Gilson Aaron , Xiong Ka , Stone Jamie , Jacobson Nora , Phelan Cynthia , Reddy Apoorva , Chui Michelle 
Published: February 2020

Background and Objectives: Over-the-counter (OTC) medication use has increased safety risks for adults older than 65. Most older adults purchase OTC medications from community pharmacies, where the considerable distance or visual obstructions between the prescription area and OTC aisles undermine pharmacists’ ability to assist patients with OTC medication decisions. An innovative redesign of an abbreviated medication section specifically for older adults (called the Senior SectionTM) can facilitate pharmacy staff/patient interaction, potentially improving safe medication selection and use. This study evaluated the impact of the Senior Section on the frequency and content of OTC encounters between pharmacy staff and patients.
Research Design and Methods: An intervention mixed-methods design generated data from patient OTC encounters, and interviews with two pharmacists and two technicians, throughout the study. NVivo was used to code interview transcripts, and frequencies and chi-square analyses demonstrated pre/post-intervention comparisons for the OTC encounter variables.
Results: After Senior Section implementation, pharmacy staff were more likely to initiate (and be involved in) patient encounters, address more topics or problem/symptoms, provide details about OTC products, discuss appropriateness of OTC use, and discuss medication classes highlighted in the Senior Section. Pharmacy staff were less likely to need to leave the prescription department for extended periods; they also had fewer prolonged encounters or encounters about product location. Importantly, the Senior Section did not impede pharmacy workflow.
Discussion and Implications: The Senior Section prompted more frequent, effective, and efficient engagements between pharmacy staff and patients, which may substantially reduce OTC-related harms among older adults.

Article Type: Original Research
A clínica da psicose: Uma direção à possibilidade
Authors: Morais Fernanda Gonçalves de Abreu Rocha de , Oliveira Rayssa Caroline de , Gusmão Ricardo Otávio Maia 
Published: February 2020

Introdução: A clínica com a psicose produz enigmas que se apresentam no contexto da Atenção Psicossocial e instituições. Este estudo de revisão narrativa teve por objetivo produzir considerações teóricas e críticas acerca das especificidades à clínica da psicose a partir das contribuições da psicanálise. Revisão Bibliográfica: em Freud, utilizou-se: “Caso Schereber” (1911/1996), “Introdução ao narcisismo” (1914/1996), “A teoria da libido e o narcisismo” (1916-1917/1996), “Neurose e Psicose” e “A perda da realidade na Neurose e Psicose”, ambos de (1924/1996). Em Lacan, usou-se: “Seminário - livro 3 “As Psicoses” (1955-6/1998) e “De uma questão preliminar a todo tratamento possível na psicose” (1958/ 1998). Além disso, artigos de estudiosos de Freud e de Lacan foram usados. A discussão foi apresentada através dos seguintes tópicos: Teoria do narcisismo na psicose; As manifestações de corpo na clínica da psicose; O desencadeamento psicótico e a estabilização; A questão da transferência na psicose; e Impasses institucionais na clínica da psicose. Considerações Finais: as alterações no processo da linguagem implicam nas manifestações bem características dessa clínica, como exemplo acontecimentos de corpo, alucinações e delírios. Apesar disso, Lacan em seu ensino propõe a possibilidade de pensar o manejo da transferência na clínica da psicose pela via do secretariado.
Gravidez pós cirurgia bariátrica: uma revisão integrativa
Authors: Rosales July Jenny Blas , Camac Luis Alberto Leon , Cardoso Jacinta Lima Rogério , Nascimento Larissa Boaes , Westry Alan Guillermo Avila 
Published: February 2020

Objetivo: Pesquisar na literatura científica quais são os fatores de risco associados a gravidez pós cirurgia bariátrica, bem como seus benefícios e recomendações. Métodos: Foi realizada uma revisão bibliográfica nas bases de dados PUBMED, Science Direct, NCBI e Scielo, usando como critério de inclusão artigos originais disponíveis, publicados no período de 2015 a 2019, nos idiomas inglês e português, e como critérios de exclusão, artigos duplicados e aqueles sem relação com o tema. As buscas foram realizadas utilizando como descritores “Pregnancy after bariatric surgery”, “Bariatric surgery and gestation” “Bariatric surgery and pregnancy” e “Complications in pregnancy bariatric surgery”. Resultados: Compõem essa pesquisa 12 artigos, nos quais foi possível averiguar que a gestação pós cirurgia bariátrica deve ser concebida no período entre 12 a 24 meses após o procedimento, com a finalidade de evitar complicações materno e fetal assim como menor tempo de duração da gestação, partos prematuros espontâneos, abortos, malformações congênitas. Considerações Finais: Mulheres que engravidam após cirurgia bariátrica apresentam menor risco de apresentar diabetes gestacional, hipertensão gestacional, macrossomia fetal e maior risco de apresentar deficiências nutricionais maternas assim como recém-nascido com baixo peso ao nascer, restrição de crescimento intrauterino, partos prematuros e mortalidade intrauterina e neonatal.
Induction of apoptosis by Stichopus chloronotus and Holothuria nobilis fractions in the human cervical cancer cell line, HeLa
Authors: Gul-e-Saba Chaudhry  , Murni Nur Islamiah kassim  , Muhammad Naveed Zafar  , Habsah Mohamad  , Yosie Andriani  , Noraznawati Ismail  , Tengku Sifzizul Tengku Muhammad  , Yeong Yik Sung  
Published: February 2020

Cancer is an uncontrolled growth of rapidly dividing cells. Decreased efficacy of current anticancer drugs urges to further screening and investigation for a better alternative to current chemotherapeutics. Natural products of marine origin are great sources of potential new drugs of enhanced biological activities. Thus, the work aims to investigate the cytotoxic effects along with the mode of cell death exerted by SC-8, SC-9, HN-3, HN-4 and HN-5 fractions prepared from Stichopus chloronotus and Holothuria nobilis marine-sponge on the human cervical cell line, HeLa. The fractions produced effective cytotoxicity with IC50 values at 72hr of less than 30 μg/ml in the order of HN-3 > HN-4 > SC-9 > SC-8 > HN-5. These fraction induced cytotoxicity via mediating apoptosis in HeLa cells. The early apoptosis was done by fractions via exposure of protein phosphatidylserine (PS) to the outer leaflet of the plasma membrane and late apoptosis confirmed due to the presence of fragmented DNA in treated cells. The presence of potentially bioactive compounds in these fractions might be responsible for inducing apoptosis and, thus, own potential to be a successful candidate for exploring forthcoming chemotherapeutic drugs
Quality of sleep and changes in the level of blood pressure
Authors: Aruna Jothishanmugam  , K Sithara Begum , Hawa Ibrahim Abd Alla Hamid  , Amani Abdelgader Mohammed  
Published: February 2020

Sleep is a naturally recurring state of mind and body in which the main features are the changes in the level of consciousness, reduced sensory and motor activity and reduced interactions with the environment. We need to have adequate sleep to maintain an optimal health and wellbeing. Human beings need to sleep at least 6 hours during night to maintain optimal health. People who are sleeping five hours or less than five hours can alter the level of blood pressure. Sleep promotes general health, concentration and regulates the blood stress hormones and it keeps our nervous system healthy. If a person doesn’t have adequate sleep for a longer period, can change the level of stress hormone in the blood and it can increase the level of blood pressure. This study was done to find out the relationship between quality of sleep and the level of blood pressure among working adults. The descriptive research design was used to assess the relationship between qualities of sleep with the history of changes in the level of blood pressure of working adults. The study was done among the working people who are living in Jazan region. Based on the inclusion and exclusion criteria, a total of 30 participants were selected by using convenient sampling technique. The Quality of sleep of the participants was assessed by using Pittsburgh Sleep Quality Index questionnaire (PSQI). The total number of male participants were 4 and female participants were 26. Majority of them were in the age group between 30 and 40 years, and most of them had a preference for mixed food habits. Majority of them were in the age group between 30 and 40 years, and most of them preferred mixed food habits. Assessment of the quality of sleep of participants shows that overall 60% of the participants have poor sleep quality.
Preliminary Assessment of the Antihypertensive and Antioxidative Activities of the Peptides from “Saba” Banana (Musa balbisiana Colla) Flesh
Authors: Magpantay Eugene Clark L. , Sucgang Ana Teresa B. , Clemencia Mia Clare Marie B. , Villar Teofila D. C. , Torio Mary Ann O. 
Published: February 2020

The crude proteins were isolated using 0.125 M Tris-HCl with 50 mM NaCl at pH 7.4. The protein content of the crude extract was determined using the Lowry assay and was found to be 4.28 mg/mL. The major band which corresponds to the major protein has an approximate molecular weight of 20 KDa. The isolated crude proteins were subjected to enzymatic digestion using pepsin, trypsin, chymotrypsin, and thermolysin for 3, 4, 12, and 24 hours. The 24-hour digest was found to have the highest percent anti-Angiotensin Converting Enzyme (ACE) activity (36.02%) while the 12-hour digest was found to have the highest anti-oxidative activity (33.14%) using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The 24-hour digest was subjected to Ultra-Performance Liquid Chromatography (UPLC) to determine the peptide fraction responsible for the ACE inhibitory activity. Three peptide fractions (PF1, PF2 and PF3) were chosen and PF2 exhibited the highest percent inhibitory activity (32.21) against ACE. PF2 was subjected to thin layer chromatography (TLC) and the possible identity is EK based on the Rf value traveled by glutamic acid (E) (0.43) and Lysine (K) (0.13). In silico analysis was done to correlate the results with the presence of putative peptides with antioxidative and antihypertensive activities. Results showed that antihypertensive peptides EK, GS, TY, FNE, FP, LKA, PT, PP, FAL and antioxidative peptides IR and VPW were found based on the sequence of the protein in “Saba” banana. The presence of the antihypertensive peptide EK was verified using thin layer chromatography (TLC).
O DEVIR COMO INTERSECÇÃO DOS CONCEITOS DE ARTE E DIREITO
Authors: Florentino Thiago , Campos Sandra 
Published: February 2020

Este artigo apresenta como foco de análise a distinção entre o entendimento dos conceitos de arte e de direito que podem ser considerados como conceitos abertos ou fechados. O objetivo deste artigo é expor a relação entre arte e direito através do conceito grego de devir. Inserindo essa conjunção em uma dinâmica de movimento e continuidade. Revelando que a simplificação do fato pela linguagem jurídica é vinculada à necessidade da retórica, consequentemente em conformidade com a Antropologia Filosófica Alemã.
Enjeux de la contextualisation de la classe inversée chez les apprenants du FLE en Iran
Authors: Gashmardi Mahmoud Reza , Hashemiannejad Bita , Shairi Hamid Reza , Rahmatian Rouhollah 
Published: February 2020

L’avènement des technologies de l’information et de la communication (TIC) dans la vie quotidienne et professionnelle nous pousse à profiter des avantages de l’accès à ces outils dans le domaine de l’enseignement et l’apprentissage du français en Iran. Les TIC nous conduisent à une nouvelle interpénétration des lieux et des pratiques de formation. Grâce aux classes inversées, les contextes traversent les quatre murs de la classe. La façon de « faire la classe » se transforme en un modèle plus pratique encourageant des méthodes pédagogiques et des activités interactives pendant le temps précieux de la classe. Le partage des savoirs, la régulation de l’apprentissage par des partenaires pédagogiques et l’interactivité augmentent dans l’espace d’apprentissage.
La nécessité de la prise en considération des paramètres locaux nous amène à une application contextualisée et appropriée de la classe inversée qui aurait des effets considérables sur l’évolution des pratiques d’enseignement et d’apprentissage du FLE en Iran. Cette étude a donc pour origine deux questions à répondre : quels sont les facteurs contextuels et éducatifs qui influent davantage sur l’application contextualisée de la classe inversée dans le cours du FLE en Iran ? Quels sont les enjeux de l’application des TIC dans la mise en place de la classe inversée ? Nos résultats s’inscrivent au croisement d’entretiens semi-directifs avec les enseignants du FLE et de questionnaires comprenant des questions ouvertes et des questions fermées auprès des apprenants du FLE en Iran. Nous avons montré l’importance de la prise en considération des facteurs contextuels et éducatifs dans l’introduction de nouvelles démarches telles que la classe inversée ainsi que les enjeux de l’application des TIC dans les cours de français en Iran.
Mots clés : Classe inversée, TIC, Contextualisation, Apprenants iraniens, FLE.