bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rearing condition may alter neonatal development of captive Bolivian squirrel monkeys (Saimiri boliviensis boliviensis)
Authors: Mulholland Michele M. , Williams Lawrence E. , Abee Christian R. 
Published: February 2020

AbstractNursery rearing has well‐known consequences for primate species. Relative to some other primate species, research has indicated a reduced impact of nursery rearing on squirrel monkeys, particularly in terms of rates, severity, and persistence of abnormal behavior. We administered the Primate Neonatal Neurobehavioral Assessment to 29 dam‐reared and 13 nursery‐reared squirrel monkeys (Saimiri boliviensis boliviensis) at 2 and 6 weeks of age. Mixed‐model ANOVAs comparing composite scores and individual assessment items across age, rearing status, and sex revealed a number of developmental differences. Dam‐reared infants scored higher on all four composite measures compared to nursery‐reared infants (p < .05) indicating that nursery‐reared animals had slower motor development, were less active and attentive, and were more passive than their dam‐reared counterparts. Consistent with infant rhesus macaques, nursery‐reared squirrel monkeys showed an increased sensitivity to tactile stimulation (p < .05). Altogether, these results suggest a disruption of species‐typical development when squirrel monkey infants are reared in a nursery setting, with activity, orientation, and state control areas most affected, though experimental research is needed to determine if this is a causal relationship. Contrary to previous behavioral research, there are likely developmental differences between dam‐reared infant squirrel monkeys and those reared in a nursery setting.
Double hybrids and time‐dependent density functional theory: An implementation and benchmark on charge transfer excited states
Authors: Ottochian Alistar , Morgillo Carmela , Ciofini Ilaria , Frisch Michael J. , Scalmani Giovanni , Adamo Carlo 
Published: February 2020

AbstractIn this paper we present the implementation and benchmarking of a Time Dependent Density Functional Theory approach in conjunction with Double Hybrid (DH) functionals. We focused on the analysis of their performance for through space charge‐transfer (CT) excitations which are well known to be very problematic for commonly used functionals, such as global hybrids.Two different families of functionals were compared, each of them containing pure, hybrid and double‐hybrid functionals.The results obtained show that, beside the robustness of the implementation, these functionals provide results with an accuracy comparable to that of adjusted range‐separated functionals, with the relevant difference that for DHs no parameter is tuned on specific compounds thus making them more appealing for a general use. Furthermore, the algorithm described and implemented is characterized by the same computational cost scaling as that of the ground state algorithm employed for MP2 and double hybrids.
Psychotherapy for personal growth? A multicultural and multitheoretical exploration
Authors: Aafjes‐van Doorn Katie , Garay Cristian , Etchebarne Ignacio , Kamsteeg Céline , Roussos Andrés 
Published: February 2020

AbstractObjectiveThis paper reports on a focus‐group discussion of four expert psychotherapy researchers facilitated at an international conference from the Society of Psychotherapy Research. A discussion was facilitated to explore their perspectives on psychotherapy practices of personal growth (intentionally working towards a strengthened sense of autonomy, mastery, and self‐acceptance) in different countries (United States, Canada, Argentina, and Chile) and different modalities (psychoanalysis, humanistic therapy, and cognitive behavioral therapy).MethodsFollowing the conference, the audio recording of this discussion was transcribed and analyzed using consensual qualitative research methods. Results. Six domains were identified; definition of personal growth, mental health care systems, psychotherapy practice, psychotherapy research, client and therapist characteristics, and social stigma.ResultsSix domains were identified; definition of personal growth, mental health care systems, psychotherapy practice, psychotherapy research, client and therapist characteristics, and social stigma.ConclusionFuture research examining the cost‐effectiveness and benefits of psychotherapy for personal growth is warranted. Building on the six domains, specific future research projects on the evidence‐based practice of psychotherapy for personal growth are suggested.
t‐Cores for (Δ+t)‐edge‐coloring
Authors: McDonald Jessica , Puleo Gregory J. 
Published: February 2020

AbstractWe extend the edge‐coloring notion of core (subgraph induced by the vertices of maximum degree) to ‐core (subgraph induced by the vertices with ), and find a sufficient condition for ‐edge‐coloring. In particular, we show that for any , if the ‐core of has multiplicity at most , with its edges of multiplicity inducing a multiforest, then . This extends previous work of Ore, Fournier, and Berge and Fournier. A stronger version of our result (which replaces the multiforest condition with a vertex‐ordering condition) generalizes a theorem of Hoffman and Rodger about cores of ‐edge‐colorable simple graphs. In fact, our bounds hold not only for chromatic index, but for the fan number of a graph, a parameter introduced by Scheide and Stiebitz as an upper bound on chromatic index. We are able to give an exact characterization of the graphs such that whenever has as its ‐core.
Development and validation of a multiplex UHPLC‐MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV
Authors: Courlet Perrine , Alves Saldanha Susana , Cavassini Matthias , Marzolini Catia , Choong Eva , Csajka Chantal , Günthard Huldrych F. , André Pascal , Buclin Thierry , Desfontaine Vincent , Decosterd Laurent Arthur 
Published: February 2020

AbstractThe widespread use of highly active antiretroviral treatments has dramatically changed the prognosis of people living with HIV (PLWH). However, such treatments have to be taken lifelong raising issues regarding the maintenance of both therapeutic effectiveness and long‐term tolerability. Recently approved or investigational antiretroviral drugs present considerable advantages, allowing once daily oral dosage along with activity against resistant variants (eg, bictegravir and doravirine) and also parenteral intramuscular administration that facilitates treatment adherence (eg, long‐acting injectable formulations such as cabotegravir and rilpivirine). Still, there remains a risk of insufficient or exaggerated circulating exposure due to absorption issues, abnormal elimination, drug‐drug interactions, and others. In this context, a multiplex ultra‐high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC‐MS/MS) bioassay has been developed for the monitoring of plasma levels of bictegravir, cabotegravir, doravirine, and rilpivirine in PLWH. A simple and convenient protein precipitation was performed followed by direct injection of the supernatant into the UHPLC‐MS/MS system. The four analytes were eluted in less than 3 minutes using a reversed‐phase chromatography method coupled with triple quadrupole mass spectrometry detection. This bioassay was fully validated following international guidelines and achieved good performances in terms of trueness (94.7%‐107.5%), repeatability (2.6%‐11%), and intermediate precision (3.0%‐11.2%) over the clinically relevant concentration ranges (from 30 to 9000 ng/mL for bictegravir, cabotegravir, and doravirine and from 10 to 1800 ng/mL for rilpivirine). This sensitive, accurate, and rapid UHPLC‐MS/MS assay is currently applied in our laboratory for routine therapeutic drug monitoring of the oral drugs bictegravir and doravirine and is also intended to be applied for the monitoring of cabotegravir/rilpivirine levels in plasma from PLWH receiving once monthly or every 2‐month intramuscular injection of these long‐acting antiretroviral drugs.
Measuring team trust: A critical and meta‐analytical review
Authors: Feitosa Jennifer , Grossman Rebecca , Kramer William S. , Salas Eduardo 
Published: February 2020

SummaryTeam trust is gaining attention in research and practice due to its benefits for team performance, yet clarity about the intricacies of its measurement is needed. Therefore, we meta‐analyzed 118 studies (N= 7,738) to untangle the role of measurement features by investigating the degree to which they influence the trust–performance relationship. Results showed that the trust–performance relationship is contingent upon time lag and source of measurement. Specifically, cross‐sectional and single‐source studies produced higher effect sizes than time‐lagged and different‐source studies. In contrast, the moderating roles of conceptualization–operationalization alignment and referent of trust measures were not supported. Post hoc analyses revealed that affective trust is more strongly related to global, versus specific team outcomes, and that mixed‐referent items are particularly effective within intact teams, whereas the trust–performance relationship is constrained when direct consensus items are used within ad hoc teams. Furthermore, we provided a critical review that highlights the importance of composites, multilevel forces, and item content and wording. Finally, we clarified key gaps in the literature, calling for research where needed. This review serves as a bridge between conceptualization and measurement and lays the groundwork for advancing knowledge of team trust.
Three‐dimensional hip joint congruity evaluation of the borderline dysplasia: Zonal‐acetabular radius of curvature
Authors: Irie Tohru , Espinoza Orías Alejandro A. , Irie Tomoyo Y. , Nho Shane J. , Takahashi Daisuke , Iwasaki Norimasa , Inoue Nozomu 
Published: February 2020

AbstractIn theory, a hemispherical acetabulum provides the ideal hip congruity in any hip position. However, it remains unknown how the three‐dimensional acetabular morphology of borderline dysplastic and frank dysplastic hips compare to normal hips. This study inquires if borderline dysplastic zonal‐acetabular curvatures in the anterior, superior, and posterior zones are different from normal or dysplastic hips three‐dimensionally. One‐hundred and fifteen hips, grouped as control (25°≤ LCEA <40°), 36 hips; borderline (20°≤ LCEA <25°), 32 hips; dysplasia (LCEA ≤20°), 47 hips were analyzed. The radii of acetabular curvature for the anterior, superior, and posterior zones were calculated as the zonal‐acetabular radius of curvature (ZARC). The mean acetabular roof obliquity of the borderline (10.6 ± 4.3 [SD]°) was significantly larger than the control (3.0° ± 5.4°; P < .001) and smaller than the dysplasia (19.3° ± 5.7°; P < .001). Although the mean acetabular anteversion angle of the borderline (21.3° ± 3.7°) was significantly larger than control (17.9 ± 3.5°; P = .001), that of the borderline was not different from the dysplasia (23.3° ± 4.0°; P = .053). The mean anterior ZARC in the borderline (29.8 ± 2.6 mm) was significantly larger than the control (28.0 ± 2.2 mm; P = .011) and smaller than the dysplasia (31.5 ± 2.7 mm; P = .009). The mean superior ZARC in the borderline (25.7 ± 3.0 mm) was not different from the control (25.9 ± 2.2 mm; P = .934) or the dysplasia (25.8 ± 2.5 mm; P = .991). Although the mean posterior ZARC in the borderline (27.2 ± 2.5 mm) was not different from the control (26.4 ± 1.9 mm; P = .455), that of the borderline group was significantly smaller than the dysplasia (30.4 ± 3.3 mm; P < .001); that is, the severity of lateral under‐coverage affects the anterior and/or posterior zonal‐acetabular curvature.
Observation of propagating surface plasmon polaritons by using functionalized tip‐enhanced Raman spectroscopy
Authors: Awada Chawki , Dab Chahinez , Zhang Jiawei , Ruediger Andreas 
Published: February 2020

AbstractWe report on surface plasmon polaritons (SPPs) observed by functionalized‐tip/surface enhanced Raman scattering. In particular, a short‐range SPPs was detected on a rough gold film with high spatial resolution. The SPPs are launched by large noble metal nanostructures. SPPs interferences patterns with a beating period of around 400 nm are observed. Manipulation of the optical enhancement has been carried out by tuning the tip‐sample distance. An increase of Raman scattering due to the highly directional surface plasmon coupled emission is observed. A finite element simulation has been carried out in order to simulate the SPPs patterns and also the influence of the emission angle and the tip to sample distance on far field intensity. These simulations in particular confirm that the SPPs mode is resulting from the interference between the wave vector of the incident and scattered light and the wave vector of the scattered SPPs. The contribution of surface plasmon coupled emission in increasing the sensitivity of Raman intensity with a tip‐enhanced Raman scattering configuration is observed.
Spinopelvic alignment predicts disc calcification, displacement, and Modic changes: Evidence of an evolutionary etiology for clinically‐relevant spinal phenotypes
Authors: Zehra Uruj , Cheung Jason P. Y. , Bow Cora , Crawford Rebecca J. , Luk Keith D. K. , Lu William , Samartzis Dino 
Published: February 2020

AbstractLumbar disc‐displacement, Modic changes (MCs), and UTE Disc Sign (UDS) on MRI are clinically relevant spinal phenotypes that can lead to sciatica/LBP. Not all degenerated discs result in disc‐displacement, MCs and UDS, suggesting varied etiologies. Spinopelvic parameters have been implicated in various spinal disorders. Pelvic incidence (PI) is “fixed parameter” since skeletal maturity. No study has addressed disc‐displacement, MCs and UDS in context of spinopelvic parameters. Therefore, the aim of study was to determine if spinopelvic parameters are associated and predict clinically‐relevant MRI‐phenotypes. One hundred and eight population‐based subjects (mean age: 52.3 years) were recruited. Spondylolisthesis and scoliosis individuals were excluded. Lumbar lordosis (LL), PI, sacral slope (SS), and pelvic tilt (PT) were assessed on lateral plain radiographs. Disc degeneration was assessed and summated, and presence or not of disc‐displacement and MCs were noted on T2W MRI. UDS was detected on UTE. Following exclusion criteria, 95 subjects were assessed. Disc‐displacement (82.1%), MCs (52.6%), and UDS (37.9%) were associated with lower PI, SS, LL, and LL/PI index. On multivariate analyses, lower PI was significantly related to development of these MRI phenotypes (adjusted OR range:0.95‐0.92; P < .05), with critical PI value of 42° or lower exhibiting fourfold increase risk of combined phenotypes (P = .020). Of UDS discs, 39.3% had adjacent MCs and 83.6% had disc‐displacement. 87.5% of MC had directly adjacent UDS. The first study to note that PI may “predict” the development of disc‐displacement, MCs and UDS, suggesting potential sub‐variants and mechanistic susceptibility that may be grounded in spinopelvic evolution. An “evolutionary etiological pathway” of spinal phenotype development is proposed.
Prediction of Delivery Complications by First‐Trimester Ultrasound Measurement of the Gestational Sac's Distance From a Previous Cesarean Section Scar
Authors: Li Cong , Yang Pan , Luo Hong 
Published: February 2020

ObjectivesThis study was designed to investigate the clinical relationship between labor complications in the second and third trimesters and the distance from the gestational sac to a previous cesarean section (CS) scar.MethodsWe conducted a retrospective review of the electronic medical records and included all 7‐ to 9‐week transvaginal ultrasound examination reports from pregnancies with a history of a single cesarean delivery in our hospital between January 2015 and December 2017. Women were divided into 6 groups according to the distance of the gestational sac to the CS scar (groups A–F). A composite of pregnancy outcomes (gestational age at birth, delivery mode, placental abnormality, blood loss, uterine rupture, and hysterectomy) and other maternal and neonatal outcomes were assessed.ResultsA total of 699 cases were included in our study. The median gestational age was 39.0 (range, 38.1–39.9) weeks. The median intrapartum blood loss volume was 400 (range, 300–500) mL. The results showed no statistically significant difference in blood loss (P = .297) or birth weight of the neonate (P = .318) among the distance subgroups. Overall, the fetuses were stillborn in 9 of 699 cases (1.29%). There was a statistically significant difference in a morbidly adherent placenta, placenta previa, and preterm labor, and their incidence increased with decreasing distance (P < .001; P for trend < .05). There was no statistically significant difference in uterine rupture (P = .597) or the delivery mode (P = .187) among the subgroups.ConclusionsThe relative positions of a CS scar and the gestational sac in the first trimester are associated with the incidence of placental abnormalities. As the distance decreases, the extent of a morbidly adherent placenta increases.
Assembly and Characterization of Biocompatible Coenzyme Q10‐Enriched Lipid Nanoparticles
Authors: Moschetti Anthony , Vine Lucas N. , Lethcoe Kyle , Dagda Ruben K. , Ellison Patricia , Ryan Robert O. 
Published: February 2020

AbstractCoenzyme Q10 (CoQ10) is a strongly hydrophobic lipid that functions in the electron transport chain and as an antioxidant. CoQ10 was conferred with aqueous solubility by incorporation into nanoparticles containing phosphatidylcholine (PtdCho) and apolipoprotein (apo) A‐I. These particles, termed CoQ10 nanodisks (ND), contain 1.0 mg CoQ10/5 mg PtdCho/2 mg apoA‐I (97% CoQ10 solubilization efficiency). UV/Vis absorbance spectroscopy of CoQ10 ND revealed a characteristic absorbance peak centered at 275 nm. Incorporation of CoQ10 into ND resulted in quenching of apoA‐I tryptophan fluorescence emission. Gel filtration chromatography of CoQ10 ND gave rise to a single major absorbance peak and HPLC of material extracted from this peak confirmed the presence of CoQ10. Incubation of cultured cells with CoQ10 ND, but not empty ND, resulted in a significant increase in the CoQ10 content of mitochondria as well as enhanced oxidative phosphorylation, as observed by a ~24% increase in maximal oxygen consumption rate. Collectively, a facile method to solubilize significant quantities of CoQ10 in lipid nanoparticles has been developed. The availability of CoQ10 ND provides a novel means to investigate biochemical aspects of CoQ10 uptake by cells and/or administer it to subjects deficient in this key lipid as a result of inborn errors of metabolism, statin therapy, or otherwise.
Value of Full‐Field Optical Coherence Tomography Imaging for the Histological Assessment of Head and Neck Cancer
Authors: De Leeuw Frederic , Abbaci Muriel , Casiraghi Odile , Ben Lakhdar Aïcha , Alfaro Alexia , Breuskin Ingrid , Laplace‐Builhé Corinne 
Published: February 2020

Background and ObjectivesIn head and neck surgery, intraoperative and postoperative evaluation of tumor margins is achieved by histopathological assessment, which is a multistep process. Intraoperative analysis of tumor margins to obtain a preliminary diagnosis is usually carried out on frozen sections. Analysis of frozen sections is challenging due to technical difficulties in processing. Full‐field optical coherence tomography (FFOCT) provides ex vivo images of fresh tissue samples at a microscopic scale without tissue processing. The objectives of our study were to define the diagnostic criteria required to interpret head and neck FFOCT images and to evaluate the reliability of a histological diagnosis made on an “optical biopsy” produced by head and neck FFOCT imaging compared with conventional histology.Study Design/Materials and MethodsFirst, we established an atlas of comparative images (FFOCT/standard histology) and defined the diagnostic criteria based on FFOCT images. Two pathologists subsequently performed a blinded review on 57 FFOCT images (32 patients). Specificity and sensitivity were measured by comparison with the standard histological diagnosis. The primary endpoint was major concordance, defined as two classifications leading to the same therapeutic decision (treatment/no treatment).ResultsPathologists identified four main criteria for tissue diagnosis on FFOCT images: heterogeneous cell distribution, stromal reaction, coiling, and keratinization abnormalities. The correlation study showed good results, with sensitivity from 88% to 90% and specificity from 81% to 87%, regardless of whether the FFOCT image review was performed by a pathologist with or without previous experience in optical imaging.ConclusionsOur results demonstrate that FFOCT images can be used by pathologists for differential diagnosis, and that high‐resolution FFOCT imaging can provide an assessment of microscopic architecture in head and neck tissues without tissue processing requirements. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.
Characterization and thermodynamic study of nanostructured Cu‐26Zn‐4Al (wt.%) shape memory alloy through mechanical alloying
Authors: Mayahi R. , Shokuhfar A. , Vaezi M.R. 
Published: February 2020

AbstractIn the current study, nanostructured Cu−Zn−Al ternary alloy was synthesized via mechanical alloying. The structural evolutions were also measured using x‐ray diffraction and scanning electron microscope. The results showed an increase in lattice strain while the crystallite size decreased. Afterwards, thermodynamic analysis was carried out on Cu−Zn, Cu−Al and Zn−Al binary systems through Miedema's semi‐empirical model. It was found that in all binary systems, there is a driving force for solid solution formation over all compositions due to its negative Gibbs free energy changes in those compositions, whilst, this value is positive for the formation of amorphous phase over some compositions which can be attributed to the absence of driving force. Finally, the extended version of Miedema's semi‐empirical model was used and discussed in detail to determine the thermodynamic desirability of solid solution and amorphous phase formation for Cu−Zn−Al ternary system. It was concluded that in this ternary system, the minimum thermodynamic driving force for solid solution formation occurred for those compositions which were located in the corners of ternary diagram.
The effect of micro alloying elements (vanadium, titanium) additions on the austenite grain growth behavior in medium carbon steel containing nitrogen
Authors: Fang W. , Zhang C. , Gou F. , Jiang B. , Zhang C. , Liu Y. 
Published: February 2020

AbstractThe austenite grain growth behavior of microalloying elements free steel (nitrogen steel) and micro alloyed steel (V−N steel and V−Ti−N steel) was investigated. The equilibrium dissolving behavior of precipitates was calculated by thermodynamic software and the morphology was observed by tunneling electron microscope. Moreover, grain growth kinetics was analyzed through theoretical calculation. Results show that the austenite grain size of V−N steel and V−Ti−N steel are significantly refined by the undissolved precipitates compared to nitrogen steel. Due to higher dissolving temperature of (vanadium, titanium)(carbon, nitrogen), the austenite grain of V−Ti−N steel keeps fine and increases slowly from 900 °C to 1250 °C. The difference of activation energy between V−N steel and V−Ti−N steel was supposed to come from the effect of different kinds of precipitates on the austenite grain growth. Compared to the vanadium rich (vanadium, titanium)(carbon, nitrogen), the titanium rich (vanadium, titanium)(carbon, nitrogen) is larger and more stable in view of its existence at higher temperature. The decrease of pinning forces can be attributed to the decrease of volume fraction and increase of radius of (vanadium, titanium)(carbon, nitrogen). Compared with critical grain sizes, the larger experimental grain sizes lead to grain growth from 900 °C to 1250 °C.