bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the penetration, development and reproduction of Meloidogyne javanica and M. graminicola on partially resistant Oryza sativa cultivars from East Africa
Authors: Nzogela Yasinta Beda , Luzi-Kihupi Ashura , De Waele Dirk , Gheysen Godelieve 
Published: April 2020

Summary
The host response to Meloidogyne javanica infection of selected Oryza sativa and NERICA (New Rice for Africa) genotypes that are commonly grown in Tanzania and East Africa was examined. The O. sativa genotypes ‘Komboka’ and ‘Supa’ appeared to be partially resistant. A further experiment showed that both genotypes are also partially resistant to M. graminicola infection. The host response of ‘Komboka’ and ‘Supa’ to M. javanica and M. graminicola was further examined and compared in indoor growth chamber conditions. The genotypes ‘TOG5674’, ‘TOG5675’, ‘CG11’ and ‘CG14’ (both O. glaberrima) were included as the resistant reference genotypes for M. graminicola and the genotype ‘UPLRi-5’ (O. sativa) was included as the susceptible reference genotype for both species of root-knot nematodes. Meloidogyne graminicola was more aggressive on ‘Komboka’ and ‘Supa’ than M. javanica. Significantly less root galling was observed on ‘Komboka’ and ‘Supa’ than on ‘UPLRi-5’. In ‘Komboka’ and ‘Supa’ significantly fewer second-stage juveniles (J2) were able to penetrate the roots, to develop into adult females and to reproduce compared with ‘UPLRi-5’. Differential emigration of J2 from the roots of ‘Komboka’ and ‘Supa’ compared with ‘UPLRi-5’ contributed to the observed partial resistance in these genotypes to M. graminicola and M. javanica. Nematodes that successfully penetrated and developed in ‘Komboka’ and ‘Supa’ showed aberrant phenotypes. ‘Supa’ and ‘Komboka’ may be recommended for use by farmers in M. javanica and M. graminicola-infested fields.
Criteria and Constraints: the Human Rights Committee’s Test on Limiting the Freedom of Religion or Belief
Authors: Gunatilleke Gehan 
Published: April 2020

Abstract
The Human Rights Committee—the treaty body established under the International Covenant on Civil and Political Rights—performs a vital function in supervising the Covenant’s implementation. This article presents an analytical account of the Committee’s approach to determining the permissibility of limitations on the freedom of religion or belief under the Covenant. It finds that the Committee has set out certain primary legal criteria when determining the permissibility of a limitation. The Committee has then articulated certain additional normative constraints that apply to states’ authority to limit rights—such as the requirement that the limitation be compatible with the principle of non-discrimination. Based on an analysis of the Committee’s general comments and jurisprudence, the author argues that the Committee has offered a path towards imposing on states a heavier burden to justify limitations on the freedom of religion or belief.
Limitations to Freedom of Religion or Belief in Indonesia: Norms and Practices
Authors: Bagir Zainal Abidin , Asfinawati  , Suhadi  , Arianingtyas Renata 
Published: April 2020

Abstract
The landscape of freedom of religion or belief (FoRB) in Indonesia has been shaped by two elements: first, the progressive adoption of human rights in the new laws and amended constitution, as a result of the democratization which started in 1998; second, the old governance of religion which acknowledges limited religious pluralism and emphasizes harmony over freedom. A striking feature resulting from this combination is the addition of “religious values” as a ground of FoRB limitation in the new chapter on human rights in the amended Constitution, which otherwise draws its inspiration from the ICCPR and other international human rights covenants. Indonesian “public order” and “public morals” are understood to consist of, among other things, respect and protection of religious values. While the emphasis on religious values and public order produces most restrictions, when it comes to limitations to FoRB on grounds of public health, the government seems reluctant to impose necessary restrictions.
ENSO Teleconnections and Impacts on U.S. Summertime Temperature during a Multiyear La Niña Life Cycle
Authors: Jong Bor-Ting , Ting Mingfang , Seager Richard , Anderson Weston B. 
Published: April 2020

AbstractEl Niño–Southern Oscillation (ENSO) teleconnections have been recognized as possible negative influences on crop yields in the United States during the summer growing season, especially in a developing La Niña summer. This study examines the physical processes of the ENSO summer teleconnections and remote impacts on the United States during a multiyear La Niña life cycle. Since 1950, a developing La Niña summer is either when an El Niño is transitioning to a La Niña or when a La Niña is persisting. Due to the distinct prior ENSO conditions, the oceanic and atmospheric characteristics in the tropics are dissimilar in these two different La Niña summers, leading to different teleconnection patterns. During the transitioning summer, the decaying El Niño and the developing La Niña induce suppressed deep convection over both the subtropical western Pacific (WP) and the tropical central Pacific (CP). Both of these two suppressed convection regions induce Rossby wave propagation extending toward North America, resulting in a statistically significant anomalous anticyclone over northeastern North America and, therefore, a robust warming signal over the Midwest. In contrast, during the persisting summer, only one suppressed convection region is present over the tropical CP induced by the La Niña SST forcing, resulting in a weak and insignificant extratropical teleconnection. Experiments from a stationary wave model confirm that the suppressed convection over the subtropical WP during the transitioning summer not only contributes substantially to the robust warming over the Midwest but also causes the teleconnections to be different from those in the persisting summer.
SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS
Authors: Malcovati Luca , Stevenson Kristen , Papaemmanuil Elli , Neuberg Donna , Bejar Rafael , Boultwood Jacqueline , Bowen David T. , Campbell Peter J. , Ebert Benjamin L. , Fenaux Pierre , Haferlach Torsten , Heuser Michael , Jansen Joop H. , Komrokji Rami S. , Maciejewski Jaroslaw P. , Walter Matthew J. , Fontenay Michaela , Garcia-Manero Guillermo , Graubert Timothy A. , Karsan Aly , Meggendorfer Manja , Pellagatti Andrea , Sallman David A. , Savona Michael R. , Sekeres Mikkael A. , Steensma David P. , Tauro Sudhir , Thol Felicitas , Vyas Paresh , Van de Loosdrecht Arjan A. , Haase Detlef , Tüchler Heinz , Greenberg Peter L. , Ogawa Seishi , Hellstrom-Lindberg Eva , Cazzola Mario 
Published: April 2020

Abstract
The 2016 revision of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics. Notwithstanding, the myelodysplastic syndrome (MDS) with isolated del(5q) remains so far the only MDS subtype defined by a genetic abnormality. Approximately half of MDS patients carry somatic mutations in spliceosome genes, with SF3B1 being the most commonly mutated one. SF3B1 mutation identifies a condition characterized by ring sideroblasts (RS), ineffective erythropoiesis, and indolent clinical course. A large body of evidence supports recognition of SF3B1-mutant MDS as a distinct nosologic entity. To further validate this notion, we interrogated the data set of the International Working Group for the Prognosis of MDS (IWG-PM). Based on the findings of our analyses, we propose the following diagnostic criteria for SF3B1-mutant MDS: (1) cytopenia as defined by standard hematologic values, (2) somatic SF3B1 mutation, (3) morphologic dysplasia (with or without RS), and (4) bone marrow blasts &lt;5% and peripheral blood blasts &lt;1%. Selected concomitant genetic lesions represent exclusion criteria for the proposed entity. In patients with clonal cytopenia of undetermined significance, SF3B1 mutation is almost invariably associated with subsequent development of overt MDS with RS, suggesting that this genetic lesion might provide presumptive evidence of MDS in the setting of persistent unexplained cytopenia. Diagnosis of SF3B1-mutant MDS has considerable clinical implications in terms of risk stratification and therapeutic decision making. In fact, this condition has a relatively good prognosis and may respond to luspatercept with abolishment of the transfusion requirement.
Predicting potential adverse events using safety data from marketed drugs
Authors: Daluwatte Chathuri , Schotland Peter , Strauss David G. , Burkhart Keith K. , Racz Rebecca 
Published: April 2020

Abstract
Background
While clinical trials are considered the gold standard for detecting adverse events, often these trials are not sufficiently powered to detect difficult to observe adverse events. We developed a preliminary approach to predict 135 adverse events using post-market safety data from marketed drugs. Adverse event information available from FDA product labels and scientific literature for drugs that have the same activity at one or more of the same targets, structural and target similarities, and the duration of post market experience were used as features for a classifier algorithm. The proposed method was studied using 54 drugs and a probabilistic approach of performance evaluation using bootstrapping with 10,000 iterations.

Results
Out of 135 adverse events, 53 had high probability of having high positive predictive value. Cross validation showed that 32% of the model-predicted safety label changes occurred within four to nine years of approval (median: six years).

Conclusions
This approach predicts 53 serious adverse events with high positive predictive values where well-characterized target-event relationships exist. Adverse events with well-defined target-event associations were better predicted compared to adverse events that may be idiosyncratic or related to secondary target effects that were poorly captured. Further enhancement of this model with additional features, such as target prediction and drug binding data, may increase accuracy.
Association between extracellular volume control and survival in patients on short daily haemodialysis
Authors: Barra Ana Beatriz Lesqueves , Roque-da-Silva Ana Paula , Vasconcellos Marcos S. , Lugon Jocemir R. , Strogoff-de-Matos Jorge Paulo 
Published: April 2020

Abstract
Background
Fluid overload (FO) assessed by bioimpedance spectroscopy (BIS) is associated with higher mortality risk in maintenance haemodialysis (HD). The aim was to assess if a better management of FO through short daily haemodialysis (SDHD) could improve survival.

Methods
Retrospective analysis of patients who were on HD 3 sessions/week for at least 3 months and shifted to in-centre SDHD (5 or 6 sessions/week, 2 to 3 h/session) between July 2012 and June 2016 at 23 dialysis units in Brazil. The 12-month risk of death was analysed according to the predialysis hydration status measured before and 6 months after initiation of SDHD. Predialysis hydration status was considered adequate when FO ≤15% of extracellular volume.

Results
A total of 297 patients on SDHD were included in the analysis. Their median age was 57 (IQR 45–67) years, 62% were males, 44% diabetics, 57% on 6 dialysis sessions/week, with a median session duration of 130 (IQR 120–150) minutes. BIS assessment at initiation of the SDHD regimen was performed in 220 patients and FO > 15% was found in 46.4%. Twelve-month survival rates for those with FO ≤15 and > 15% before initiating SDHD were 87.4 and 88.0%, respectively (P = 0.92). BIS analysis when completing 6 months on SDHD were available for 229 patients, 26.6% with FO > 15%. The survival rates for the next 12 months (from the 6th to the 18th month of follow-up) for those with FO ≤15 and > 15% were 91.0 and 72.0%, respectively (P = 0.0006). In a Cox regression model, after adjustment for demographic, clinical and laboratory variables, FO ≤ 15% persisted associated with a lower mortality risk (hazard ratio 0.34, 95%CI 0.13–0.87).

Conclusions
Moving from conventional HD to SDHD was associated with better control of excessive extracellular volume. Patients who reached or maintained predialysis fluid overload ≤15% after initiating SDHD presented a lower risk of death.
The experiences of mothers with preterm infants within the first-year post discharge from NICU: social support, attachment and level of depressive symptoms
Authors: Leahy-Warren Patricia , Coleman Chelsea , Bradley Róisín , Mulcahy Helen 
Published: April 2020

Abstract
Background
The estimated global premature birth rate for 2014 was 10.6%, equating to an estimate of 14.84 million live premature births. The experience of premature birth does not impact solely on the infant and mother as individuals but occurs in the context of a critical point in time when they are developing a relationship with one another. The aim of this study was to investigate the relationships between social support, mother to infant attachment, and depressive symptoms of mothers with preterm infants within the first 12 months’ post discharge from the Neonatal Intensive Care Unit (NICU).

Methods
A correlational cross-sectional study design was used. Data were collected using a four-part online survey which included the Perinatal Social Support Questionnaire (PICSS), Maternal Postnatal Attachment Scale (MPAS) and the Edinburgh Postnatal Depression Scale (EPDS) with mothers of preterm infants (n = 140).

Results
The prevalence of postnatal depression was 37.9% (95% CI: 29.8 to 46.4%). In univariable analyses, history of depression (p = 0.005), aged 35–39 years (p = 0.006), no formal social support (p = 0.040), less informal social supports (p = 0.018), lower overall maternal attachment (p < 0.001) and lower overall functional social support (p < 0.001) were significantly associated with a higher level of depressive symptoms. Lower scores on two of the maternal attachment subscales (quality of attachment and absence of hostility) and all four of the functional social support subscales were significantly associated with a higher level of depressive symptoms (p < 0.001 for all). In the multivariable analysis, prior history of depression (p = 0.028), lower score of maternal attachment (p < 0.001) and lower emotional functional social support (p = 0.030) were significantly associated with a higher level of depressive symptoms.

Conclusion
Women who experience a premature birth, have a prior history of depression, poor infant attachment and poor emotional social support have a higher level of depressive symptoms. Results emphasise the need for professionals to encourage mobilisation of maternal formal and informal social supports. It is important to intervene early to address maternal emotional well-being and enhance the developing mother-preterm infant relationship.
Ethnicity, religious affiliation and girl-child marriage: a cross-sectional study of nationally representative sample of female adolescents in Nigeria
Authors: Mobolaji Jacob Wale , Fatusi Adesegun O. , Adedini Sunday A. 
Published: April 2020

AbstractBackgroundThe persistently high prevalence of girl-child marriage remains a public health and developmental concern in Nigeria. Despite global campaign against the practice and policy efforts by Nigerian government, the prevalence remains unabated. This study investigates the prevalence and the influence of ethnicity and religious affiliation on the girl-child marriage among female adolescents in Nigeria.MethodsData of 7804 girls aged 15–19 years extracted from the 2013 Nigeria Demographic and Health Survey were used. Ethnic groups were classified into five: major Northern ethnic group (Hausa/Fulani); Northern ethnic minorities; two major Southern ethnic groups (Yoruba and Igbo), and Southern ethnic minorities. The prevalence of girl-child marriage was determined for the five ethnic groups and individually for each ethnic minority group. Relationships between ethnicity and religious affiliation on girl-child marriage were explored using Cox proportional hazard regression models, adjusting for residence, education and wealth quintile.ResultsChild marriage was higher for the Northern majority ethnic group of Hausa/Fulani (54.8%) compared to the two major Southern ethnic groups (3.0–3.6%) and aggregated Northern ethnic minorities (25.7%) and Southern minorities (5.9%). However, overall, the less known Northern ethnic minority groups of Kambari (74.9%) and Fulfude (73.8%) recorded the highest prevalence. Compared to the major Southern ethnic group of Yoruba, the adjusted hazard ratio (AHR) of child marriage was significantly higher for Northern ethnic minorities (AHR = 2.50; 95% C.I. = 1.59–3.95) and Northern major ethnicity (AHR = 3.67, 95% C.I. = 2.33–5.77). No significant difference was recorded among Southern ethnic groups. Girls affiliated to other religions (Muslim and traditionalist) had higher child-marriage risks compared to Christians (AHR = 2.10; 95% C.I. = 1.54–2.86).ConclusionEthnicity and religion have independent associations with girl-child marriage in Nigeria; interventions must address culturally-laden social norms that vary by ethnic groups as well as religious-related beliefs.
LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-β1
Authors: Jiang Xueqin , Wang Jiong , Fang Lei 
Published: April 2020

Abstract
Background
LncRNA WT1-AS is a recently identified potential tumor suppressor in gastric cancer. This study mainly explored the role of WT1-AS in non-small cell lung cancer (NSCLC).

Methods
WT1-AS and TGF-β1 mRNA in two types of tissues of 74 NSCLC patients were detected by performing RT-qPCR experiments. WT1-AS and TGF-β1 expression vectors were established using the pcDNA3.1 vector. Protein concentration was measured by BCA assay. Mean values in this study were calculated using the data of three biological replicates of each experiment.

Results
We found that WT1-AS was down-regulated, while TGF-β1 was upregulated in NSCLC tissues. Survival analysis showed that low levels of WT1-AS expression predicted poor survival of NSCLC patients. WT1-AS and TGF-β1 were inversely correlated in NSCLC tissues. Over-expression experiments revealed down-regulated TGF-β1 after WT1-AS over-expression, while TGF-β1 over-expression failed to affect WT1-AS. WT1-AS over-expression resulted in inhibited cancer cell stemness. TGF-β1 over-expression played an opposite role and attenuated the effects of TGF-β1 over-expression.

Conclusion
Therefore, WT1-AS over-expression may inhibit non-small cell lung cancer cell stemness by down-regulating TGF-β1.

Trial registration
The First Affiliated Hospital of Anhui Medical University Ethics committee approved this study (AHMU20101009).
Clinical impact of advanced chronic kidney disease in patients with non-HIV pulmonary cryptococcosis
Authors: Tashiro Hiroki , Haraguchi Tetsuro , Takahashi Koichiro , Sadamatsu Hironori , Tajiri Ryo , Takamori Ayako , Kimura Shinya , Sueoka-Aragane Naoko 
Published: April 2020

AbstractBackgroundPulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. The severity of chronic kidney disease (CKD) was reported to be one of the risk factors for pulmonary cryptococcosis, but its clinical characteristics have not been fully assessed. The purpose of this study was to clarify the clinical characteristics of advanced CKD in patients with pulmonary cryptococcosis.MethodsThe present study retrospectively investigated 56 patients who had non-human immunodeficiency virus (HIV) pulmonary cryptococcosis and were treated at Saga University Hospital between 2005 and 2018. The clinical characteristics were evaluated and compared between patients with estimated glomerular filtration rate (eGFR) > 45 mL/min/1.73 m2(n = 42, early CKD) and those with eGFR < 45 mL/min/1.73 m2(n = 14, advanced CKD.ResultsCompared with patients with early CKD, those with advanced CKD had significantly higher rate of disseminated cryptococcosis (21.4% vs. 2.4%,p = 0.03); lower percentage of patients who recovered after treatment (63.6% vs. 92.5%,p = 0.02); and more frequent clinical features of fever (57.1% vs. 19.0%,p < 0.01), pleural effusion (21.4% vs. 2.4%,p = 0.03), high white blood cell count (8550/mL vs. 6150/mL,p = 0.01) and C-reactive protein (CRP) (2.1 mg/dL vs. 0.2 mg/dL,p = 0.02), and low level of serum albumin (3.0 g/dL vs. 3.8 g/dL,p < 0.01). Multivariate analysis adjusted by immunosuppressive drug use indicated the significant factors of fever (odds ratio or β value [95% confidence interval] 6.4 [1.65–20.09],p < 0.01), high white blood cell count (1293.2 [110.2–2476.2],p = 0.03), C-reactive protein (0.89 [0.18–1.59],p = 0.01) and low level of serum albumin (− 0.34 [− 0.54 – − 0.14],p < 0.01) in patients with eGFR < 45 mL/min/1.73m2.ConclusionAdvanced CKD was associated with poor clinical characteristics and outcomes in patients with non-HIV pulmonary cryptococcosis.Trial registrationThe patients in this study were registered retrospectively.
Reconstruction of finger joints using autologous rib perichondrium – an observational study at a single Centre with a median follow-up of 37 years
Authors: Muder Daniel , Nilsson Ola , Vedung Torbjörn 
Published: April 2020

AbstractBackgroundGratifying long-term results are difficult to achieve when reconstructing osteoarthritic finger joints. Implant surgery is the most commonly used method to restore function and dexterity. However, all types of implant have disadvantages and may be a less favorable option in some cases, especially in young patients with a long expected lifetime and high demands on manual load. Implant related complications as loosening, instability, subsidence and stiffness are the main concerns. In this context, joint reconstruction using rib perichondrium might be a reasonable alternative in selected cases. The aim of the study was to evaluate the long-term results of finger joint reconstruction using rib perichondrial transplantation.MethodsThe study group (n = 11) consisted of eight individuals reconstructed in the proximal interphalangeal (PIP) joints and three reconstructed in the metacarpophalangeal (MCP) joints during 1974–1981. All patients were evaluated at clinical visits (median: 37 years after perichondrial transplantation, range: 34–41 years) using radiographs, disability in arm-shoulder-hand (DASH) score, Visual Analog Scale (VAS), range-of-motion (ROM) and manual strength (JAMAR).ResultsNone of the 11 patients had undergone additional surgery. All of the PIP-joints (n = 8) were almost pain-free at activity (VAS 0,6) (range 0–4), had an average range-of-motion of 41 degrees (range 5–80) and a mean DASH-score of 8,3 (range 1–51). The mean strength was 41 kg compared to 44 kg in the contralateral hand (93%). The three MCP joints were almost pain-free at activity (VAS 0,7), (range 0–1). The ROM was on average 80 degrees (range 70–90) and the mean DASH-score was 2 (range 1–3). The mean strength was 43 kg compared to 53 kg in the contralateral hand (81%).ConclusionsPerichondrium transplants restored injured PIP and MCP joints that remained essentially pain-free and mostly well-functioning without need for additional surgeries up to 41 years after the procedure. Additional studies are needed to evaluate long-term results in comparison to modern implants and to better describe the factors that determine the outcome of these procedures.Level of evidenceLevel IV, Therapeutic Study.