bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Campus Data in Representing Depression Among College Students: Exploratory Research
Authors: Mei Guang , Xu Weisheng , Li Li , Zhao Zhen , Li Hao , Liu Wenqing , Jiao Yueming 
Published: November 2019

Background
Depression is a predominant feature of many psychological problems leading to extreme behaviors and, in some cases, suicide. Campus information systems keep detailed and reliable student behavioral data; however, whether these data can reflect depression and we know the differences in behavior between depressive and nondepressive students are still research problems.

Objective
The purpose of this paper is to investigate the behavioral patterns of depressed students by using multisource campus data and exploring the link between behavioral preferences and depressive symptoms. The campus data described in this paper include basic personal information, academic performance, poverty subsidy, consumption habit, daily routine, library behavior, and meal habit, totaling 121 features.

Methods
To identify potentially depressive students, we developed an online questionnaire system based on a standard psychometric instrument, the Zung Self-Rating Depression Scale (SDS). To explore the differences in behavior of depressive and nondepressive students, the Mann-Whitney U test was applied. In order to investigate the behavioral features of different depressive symptoms, factor analysis was used to divide the questionnaire items into different symptom groups and then correlation analysis was employed to study the extrinsic characteristics of each depressive symptom.

Results
The correlation between these factors and the features were computed. The results indicated that there were 25 features correlated with either 4 factors or SDS score. The statistical results indicated that depressive students were more likely to fail exams, have poor meal habits, have increased night activities and decreased morning activities, and engage less in social activities (eg, avoiding meal times with friends). Correlation analysis showed that the somatic factor 2 (F4) was negatively correlated with the number of library visits (r=–.179, P<.001), and, compared with other factors, had the greatest impact on students’ daily schedule, eating and social habits. The biggest influencing factor to poor academic performance was cognitive factor F1, and its score was found to be significantly positively correlated with fail rate (r=.185, P=.02).

Conclusions
The results presented in this study indicate that campus data can reflect depression and its symptoms. By collecting a large amount of questionnaire data and combining machine learning algorithms, it is possible to realize an identification method of depression and depressive symptoms based on campus data.
PHYTOCHEMICAL PROFILING, ASSESSMENT OF TOTAL PHENOLIC CONTENT, TOTAL FLAVONOID CONTENT, AND ANTIOXIDANT ACTIVITY OF ETHNOMEDICINAL PLANT, MEYNA SPINOSA FROM ASSAM
Authors: REKHA BORA  , SEEMA KHAKHALARY  , TAPAN DUTTA  
Published: November 2019

Objective: The present study qualitative phytoconstituents examine the total phenol, total flavonoid content (TFC), and antioxidant efficiencies traditionally used plant, Meyna spinosa.
Methods: Chemical profiling, estimation of total phenolic content (TPC), TFC, and antioxidant activity of ethanol extracts of M. spinosa have performed by applying standard protocols. Antioxidant activity of leaf and stem was evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. TPC and TFC of the plant were assessed using Folin–Ciocalteu colorimetric and aluminum colorimetric assay, respectively.
Results: The findings of the study exhibit that ethanol extract of M. spinosa is proved to be the presence of phytoconstituents (7/9) such as alkaloids, terpenoids, saponins, tannins, phytosterols, flavonoids, and phenolic compounds, while carbohydrate, fixed oils, and fats are unavailable. In addition, phenolic compositions of ethanol extract of leaf and stem; 93.21±2.93 and 54.33±0.69 mg gallic acid equivalents/g extract, respectively; TFCs of leaf and stem have recorded as 61.55±1.21 and 37.55±1.28 mg quercetin equivalents/g extract, respectively. Antioxidant efficiency of both leaf and stem is tested using DPPH radical scavenging assay as IC50 20.68±0.32 and 50.99±0.56 μg/ml, respectively.
Conclusion: From the above results, it has concluded that the ethanol extract of the M. spinosa leaves and stems seizes rich phytoconstituents which can be applied in food technology, drug industries, ethnopharmacological fields, etc., for the development of healthiness and to battle against negative health consequences.
COMPARISON OF EXTRACELLULAR SECRETION OF RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR USING TORA AND PELB SIGNAL PEPTIDES IN ESCHERICHIA COLI BL21 (DE3)
Authors: RIMA MELATI  , ANNISA INDRIYANI  , SHABARNI GAFFAR  , SRIWIDODO  , IMAN PERMANA MAKSUM  
Published: November 2019

Objective: The objective of this study was to evaluate two signal peptides (TorA and PelB), representing the most common secretion pathways in Escherichia coli, for their ability to secrete recombinant human epidermal growth factor (rhEGF) protein in the extracellular expression.
Methods: E. coli BL21 (DE3) as the host cell to be transformed using recombinant plasmid pD881-TorA the consensus already containing hEGF gene and the signal peptide TorA or PelB, then expressed by L-rhamnose induction. rhEGF purified by heat treatment and ion-exchange chromatography. The hEGF protein was characterized using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and ELISA.
Results: The result showed that PelB was secreting more hEGF protein compared to TorA with protein expression results of 48.2 μg/L and purification results of 0.360 μg/L, with a purity level of 83%.
Conclusion: The results of this study explain in extracellular expression of hEGF protein in E. coli, PelB helps hEGF protein secretion to culture media better than TorA.
A COMPREHENSIVE ANALYSIS OF DRUG PRESCRIBING PRACTICES OF DOCTORS AND COMPLETENESS OF PRESCRIPTION IN A GOVERNMENT MEDICAL COLLEGE IN NORTHERN INDIA
Authors: KAMALDEEP SINGH  , GARIMA BHUTANI  , SEEMA RANI  , RAHUL SAINI  , ARVIND NARWAT  
Published: November 2019

Objective: This study was designed to analyze the drug prescribing practices of doctors and completeness of prescriptions in a government medical college in Northern India.
Methods: A total of 2155 prescriptions were evaluated for adequacy of information related to prescribed drugs and completeness of information related to patients and doctors.
Results: The weight of the patient was written only in 1.90% prescriptions. The diagnosis was not written on 43.85% prescriptions. A total number of drugs prescribed in all the prescriptions was 6998. The average number of drugs per prescription was found to be 3.25±0.24. Out of these, 64.10% were prescribed by brand names. About 69.14% of drugs were prescribed in the form of tablets. Route of administration was not found to be mentioned for 86.08% drugs. For 53.90% drugs, dose was not mentioned. The name of the prescribing doctor was mentioned in 1.95% prescriptions only.
Conclusion: The study revealed that many prescriptions lacked crucial components of information pertaining to the drugs prescribed and the prescribing doctor. There is a vast scope for improvement by the prescribers.
TOPICAL SOLID LIPID NANOPARTICLES BASED GEL OF LAVENDER ESSENTIAL OIL FOR ANTI‑INFLAMMATORY ACTIVITY
Authors: PALLAVI M CHAUDHARI  , VAISHNAVI M BIND  
Published: November 2019

Objective: The main objective of the study was to formulate and evaluate and perform an optimization study of lavender essential oil loaded solid lipid nanoparticles (SLNs) based gel.
Materials and Methods: SLNs were prepared by the hot homogenization technique. A total of eight formulations were formulated as per 23 factorial design by design expert 11 software. The formulated SLNs were further evaluated for particle size, entrapment efficiency, drug release profile. After evaluation, the optimized batch was further used for formulating gel. The formulated gel was further subjected to ex vivo studies.
Results: After the evaluation of all the parameters, batch 7 was found to be optimized. Batch 7 was found to have the lowest particle size of 30.91±0.30, higher entrapment efficiency of 89.99±0.87, and higher drug release of 90.41±0.55. It was further used for formulating gel which was found to be consistent, homogenous, smooth, and spreadable. The % inhibition of the formulated SLN based gel was found to be 28±0.1%.
Conclusion: The SLNs were prepared and were formulated into the gel. The gel showed anti-inflammatory activity.
FORMULATION, OPTIMIZATION, AND IN VITRO EVALUATION OF POLYMERIC NANOSUSPENSION OF FLURBIPROFEN
Authors: PANKAJ JADHAV  , ADHIKRAO YADAV  
Published: November 2019

Objective: At present, more than 40% of drugs are poorly water-soluble that leads to reduced bioavailability. The objective of the present investigation was to overcome the issue of poor aqueous solubility of drug; therefore, stable flurbiprofen (FBF) nanosuspensions were developed by nanoprecipitation method.
Materials and Methods: Based on particle size, zeta potential, and entrapment efficiency, the polymeric system of hydroxypropyl methylcellulose E15 and poloxamer 188 was used effectively. The prepared formulations were evaluated for Fourier transform infrared spectroscopy, transmission electron microscopy, differential scanning calorimetry, powder X-ray diffraction, saturation solubility, entrapment efficiency, particle size, zeta potential, dissolution profile, and stability.
Results: The resultant FBF nanosuspensions depicted particles in size range of 200–400 nm and were physically stable. After nanonization, the crystallinity of FBF was slightly reduced in the presence of excipients. The aqueous solubility and dissolution rate of all FBF nanosuspensions were significantly increased as compared with FBF powder.
Conclusion: This investigation demonstrated that nanoprecipitation is a promising method to develop stable polymeric nanosuspension of FBF with significant increase in its aqueous solubility.
Comparative and International Education/Éducation comparée et internationale
Authors: Larsen Marianne A. , Sperduti Vanessa R. 
Published: November 2019

The first section of this article provides a brief history of Comparative and International Education (CIE), the official journal of the Comparative and International Education Society of Canada, over its almost 50-year history. The second section outlines general characteristics of the journal, including the role of the editors and editorial board, the bilingual nature of the journal, special issues, and book reviews. The article reviews the current general operations associated with the journal, providing details about financial aspects and changes in the production and dissemination processes as it moved from a print to an online format in 2012. Finally, the article recaps some challenges the journal has had and currently faces, as well as aspirations for the future. It demonstrates the resilience of the journal to adapt and notes the commitment of its champions, who have kept it going through challenging times.
Keywords Journal publishing; Bilingual publishing; Editorial process; Knowledge dissemination; Comparative education; International education; Canada
Résumé
La première partie de ce document présente une brève histoire de la Éducation comparéeet internationale (ECI), la revue officielle de la Société canadienne d’éducation comparée et internationale (SCECI), au cours de ses presque 50 ans d’existence. La deuxième partie est consacrée aux caractéristiques générales de la revue, notamment le rôle des éditeurs et du comité de rédaction, son bilinguisme, ses numéros spéciaux ainsi que les critiques littéraires. Sont examinées les questions générales relatives à la revue en fournissant des éléments d’information sur les aspects financiers et sur les changements apportés aux processus de production et de diffusion de la revue, passée d’un format papier à un format consultable en ligne. Enfin, sont rappelés certains défis que la revue a dû relever et continue à ce jour de relever, ainsi que ses aspirations pour l’avenir. Cet article démontre la capacité d’adaption de la revue et souligne l’engagement de ses champions qui lui ont permis de se maintenir, même en des temps difficiles.
Mots clés Publication de revues; Publication bilingue; Processus éditorial; Diffusion des connaissances; Éducation comparée; Éducation internationale; Canada
PHYTOCEMICALS SCREENING AND CELL CYCLE ARREST ACTIVITY OF n-HEXANE EXTRACT OF Vernonia amygdalina Delile LEAVES AGAINST PANCREATIC CANCER CELL LINE
Authors: Fauzan M L , Hasibuan P A  Z , Harahap U 
Published: November 2019

Objective: This study aims to determined phytochemical compounds of simplex and n-hexane extract (nHE) of Vernonia amygdalina Delile Leaves and cell cycle arrest activity against PANC-1 cells.
Methods: The leaves of Vernonia amygdalina Delile were dried and extracted with n-hexane, followed by evaporation and freeze-drying. Phytochemicals screening were analyzed with standard procedures. Cytotoxic activity was carried out using MTT assay method. PANC-1 cells were treated with different concentrations of nHE (500 ug/mL, 250 ug/mL, 125 ug/mL, 61.5 ug/mL and 31.25 ug/mL) for 24 hours to obtained IC50 values. The cell cycle inhibition activity of nHE was carried out used flowcytometry method and apoptosis activity used double staining method.
Results: Then HE was identified contains steroids/triterpenoids. The IC50 was114.80 ± 1.21 ug/mL. The nHE inhibited cell cycle PANC-1 on M1 phase (67.39%) and it was induced apoptosis process on PANC-1 cells.
Conclusions: Our results suggest that extractsn­-hexane of Vernonia amygdalina Delile Leaves had as cancer chemoprevention activities with inhibits cell cycle and spur apoptosis process on PANC-1 cells.

Keywords:
Effect of Four Essential Oils on Cells Release Membrane and Biofilm Formation of Clinical Bacterial Isolated From Oral Infection
Authors: Ngongang Dimitri Tchami , Nyegue Ascension Maximilienne , Ndedi Del Florence Esther , Etoa Xavier François 
Published: November 2019

Background: Bacterial biofilms forming are current resistant bacterial form to the treatment of oral diseases that colonizes in the gingival and sub-gingival regions of the mouth. The present study aims to screen the anti-biofilm potential and evaluate the effect of four essential oils on cells release membrane. Methods: Seven type isolate bacteria obtained during previous work were screen to select those who had ability to form biofilm using Congo Red Agar method, tube method and crystal violet method. The inhibitory parameter of biofilm forming was determine using microtiter plate method. The effect of essential oil on cell membrane release of each selected bacterial was put in evidence by measuring cellular material that absorb at 260 nm and 280 nm after 0 min, 30 min and 60 min of exposure and confirm by measuring DNA, RNA and proteins release by treated cells on extracellular medium using Nanodrop 1000 spectrophotometer. Results: The crystal violet method shows twelve (12) strong, five (05) moderate and five (05) weak biofilm forming bacteria. The anti-biofilm activity against the oral bacteria who shown that most of essentials oils have activity on different biofilm formation and the MICs ranged from 0.31 mg/mL to 1.25 mg/mL. Concentration of intracellular material released in extracellular medium ranged from 186,56 ± 2,35 ng/µL to 766,6 ± 2,84 ng/µL for DNA, 158,06 ± 1,87 ng/µL to 628,53 ± 2,05 ng/µL for RNA and 695,9 ± 2,11ng/µL to 1125,23 ± 2,15 ng/µL for proteins. Conclusion: This study demonstrates that the selected EOs have a significant anti-biofilm activity, acting on the cell surface and causing the disruption of the bacterial membrane. These EOs are interesting alternative to conventional antimicrobials for the control of oral microorganisms.
Keywords: Anti-biofilm activity, Biofilm, oral diseases
Anti-inflammatory and healing effect of leaf-flower mixture extract of Cytisus triflorus L
Authors: Madoui Soraya , Mokhnache Kamel , Khither Hanane , Aouchria Sana , Charef Noureddine 
Published: November 2019

Objective: The present study aims to study the anti-inflammatory and healing effects of the crude leaf and flower mixture extract of Cytisus triflorus L., known in Algeria as Igoulli.
Methodology and results: The method consists of studying the anti-inflammatory effect by measuring the diameter of edema of the paw of rats that received carrageenan. In addition, 2 cm diameter circular incision wounds were made in rats to evaluate the healing activity of the crude leaf and flower mixture extract of Cytisus triflorus L. at doses of 200 mg/kg and 400 mg/kg. The anti-inflammatory effect of C. triflorus showed that E.Br at the dose 400 mg has the higher activity, which induces a significant decrease in the thickness of the rat paw from the second hour, its effects being similar to those of Diclofenac. The percentages of inhibition of edema at 4 h and 6 h are 80.05 and 88.56% for E.Br and Diclofenac respectively. With respect to healing activity, the results show that after 18 days, complete healing was achieved with almost two concentrations of crude C. triflorus, tissue remodeling and reoccurrence of hair was observed at level of scars.
Conclusion: The results of the study show that the leaf extract and flower extract of Cytisus triflorus L. has healing and anti-inflammatory properties that could justify the use of this plant in traditional medicine against inflammatory diseases.
Keywords: Cytisus triflorus, anti-inflammatory, healing activity.
Evaluation of isoniazid-oxidative reactions in mice model
Authors: Mokhnache Kamel , Karbab Ahlem , Madoui Soraya , Khither Hanane , Soltani El-Khamsa , Charef Noureddine 
Published: November 2019

In this study the anti-tubercular drug; isoniazid (INH) was investigated for their adverse effect; the oxidative stress. This effect was evaluated by using mice model, at the dose of 151 mg/kg. We found that oxidative stress induced by INH is associated with lipid peroxidation expressed by the increase in the level of MDA from 76.9 ± 1.74 to 79.61 ± 2.67 nmol/g tissue. The oxidative stress of INH is accompanied by a decrease in reduced GSH level (from 79.9 ± 12 μmol / mg to 68.48 ± 4.28 μmol / mg compared to of the control group). After treatment with INH at 151 mg/kg, a decrease in CAT activities occurred compared to control (2.53 ± 0.39 U/mg Pr vs 5.07 ± 0.73 U/mg Pr).
Keywords: isoniazid, oxidative stress, MDA, GSH, CAT
Analysis of vibration status of power generating unit reducers
Authors: Пшеничный Вадим , Pshenichnyy Vadim , Сальников Алексей , Salnikov Alexey 
Published: November 2019

The reducers of power units are being studied. Dynamic analysis of the basic structural elements of reducers has been carried out. There have been found the possible causes of the increased wear of surfaces of toothed linkages of herringbone transfer. There are given the results of studying dynamic interactions by vibration characteristics of measuring the vibration level in bearing blocks and elements of reducers of power units at their technological operation mode. To analyze the frequency interaction of structural elements of the studied reducers there were used the results of modal analysis of earlier conducted researches of the reducer power unit. It has been stated that for conducting vibrodiagnostic control the third class machines were chosen due to their powerful primary engines, and other machines with rotating masses mounted on massive foundations, rigid in the direction of vibration measurement. Phase angles of high-speed and low-speed shaft wheels for the purpose of defining a corner of phase shift (torsional fluctuations of shaft wheels) at reverse frequencies and frequencies of toothed linkage have been studied. In terms
of dynamic analysis it allows to trace trajectories of linkages in toothed couples of divided wheels of herringbone gearing. The diagrams of gear trajectories are illustrated for bending vibrations
of the shaft-wheels. The research results confirming the nonlinear relationship between the level
of axial vibrations and the displacement angle of instantaneous phase angle are presented. It has been recommended to reduce the level of axial vibration transmitted from the coupling to 0.1–0.2 mm/s for eliminating uneven wear in the chevron gear; carry out structural improvements to the high-speed and low-speed shaft-wheels with increasing rigidity between the elements of chevron transmission; operate gearboxes within critical values; timely monitor the technical condition of gearboxes.
Neurologic and magnetic resonance imaging features of German Shepherd Dogs with cervical spondylomyelopathy: 10 cases (2006-2018)
Authors: Bonelli Marília de A. , da Costa Ronaldo C. 
Published: November 2019

Abstract

OBJECTIVE
To describe the neurologic signs and MRI findings for German Shepherd Dogs (GSDs) with cervical spondylomyelopathy (CSM).

ANIMALS
10 GSDs with confirmed CSM.

PROCEDURES
Medical records from January 2006 through July 2018 were reviewed to identify dogs with CSM. For each CSM-affected dog, information regarding age, duration of clinical signs, presence of neurologic signs, and treatments administered were obtained; the main site and cause of spinal cord compression and other vertebral and spinal cord changes were identified on MRI images.

RESULTS
Data for 9 male and 1 female (mean age, 6.2 years) GSDs with CSM were assessed. Dogs were classified as having chronic (n = 9) or acute (1) CSM. Nine dogs had ataxia; 1 dog had only signs of cervical hyperesthesia. Neurologic examination findings localized the lesion to the cervical portion of the vertebral column in each dog. The main spinal cord compression site was at the C6-7 (n = 5), C5-6 (4), or C4-5 (1) intervertebral spaces; osseous proliferation of the articular processes was the sole or a contributory cause of these compressions for 6 of the 10 dogs. Eight dogs also had dorsal compression of the spinal cord as the result of ligamenta flava hypertrophy.

CONCLUSIONS AND CLINICAL RELEVANCE
The 10 GSDs of the present retrospective case series had CSM that was often characterized by osseous changes and a ligamentous component and were older than dogs of other breeds (eg, Great Dane and Mastiff) with osseous-associated CSM described in previous reports. Cervical spondylomyelopathy should be a differential diagnosis for GSDs with ataxia, paresis, or signs of cervical hyperesthesia.