bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid solvent-evaporation strategy for three-dimensional cobalt-based complex hierarchical architectures as catalysts for water oxidation
Authors: Jiang Hong , Zhang Hao , Kang Qiaoling , Ma Haifeng , Tong Yinlin , Gao Feng , Lu Qingyi 
Published: October 2019

AbstractIt is a challenging task to seek a highly-efficient electrocatalyst for oxygen evolution reaction (OER) of water splitting. Non-noble Co-based nanomaterials are considered as earth-abundant and effective catalysts to lower overpotential and increase polarization current density of OER. In this work, we reported, for the first time, a “rapid solvent-evaporation” strategy for the synthesis of three-dimensional (3D) cobalt complex hierarchical architectures constructed by two-dimensional (2D) nanosheets. The 3D structured cobalt complexes have excellent performances in catalyzing OER with lower onset potential, overpotential, Tafel slope and better stability than commercial IrO2. Superior electrochemical performances would be beneficial from the unique 3D structure. This extremely simple method for 3D Co complex with good OER activities makes the complex be promising commercial OER catalyst to replace earth-rare and expensive IrO2.
Southwest Greenland shelf glaciation during MIS 4 more extensive than during the Last Glacial Maximum
Authors: Seidenkrantz Marit-Solveig , Kuijpers Antoon , Olsen Jesper , Pearce Christof , Lindblom Sofia , Ploug Johan , Przybyło Piotr , Snowball Ian 
Published: October 2019

AbstractAlthough geological and modelling evidence indicate that the last glacial inception in North America was in NE Canada, little is known about the glacial response of the nearby western Greenland Ice Sheet (GIS) during the glacial advance of marine oxygen isotope stage 4 (MIS4). Our multi-proxy study of a marine sediment core collected about 60 km southwest of the Outer Hellefisk Moraines demonstrates that in the southern Davis Strait region the most extreme Greenland shelf glaciation of the last glacial cycle occurred during MIS 4, with another prominent glacial advance at 37–33 kyr BP. During those periods the GIS likely reached the Outer Hellefisk Moraines in this area. Except for these two periods, our data suggest significant advection of relatively warm Irminger Sea Water by the West Greenland Current since MIS 4. This advection likely limited the extent of the MIS2 glaciation on the SW Greenland shelf. Decreased precipitation over southwestern Greenland predicted by atmospheric models as a downstream effect of a much larger MIS2 Laurentide Ice Sheet may have played an additional role.
MicroRNA-146a-deficient mice develop immune complex glomerulonephritis
Authors: Amrouche Lucile , You Sylvaine , Sauvaget Virginia , Manda Victoria , Lamarthée Baptiste , Desbuissons Geoffroy , Tinel Claire , Rabant Marion , Nguyen Clément , Isnard Pierre , Burtin Martine , Charles Nicolas , Legendre Christophe , Terzi Fabiola , Anglicheau Dany 
Published: October 2019

AbstractMicroRNAs (miRNAs) play an important role in the kidneys under physiological and pathological conditions, but their role in immune glomerulonephritis is unclear. miR-146a has been identified as a key player in innate immunity and inflammatory responses, and in the kidney, this miRNA is involved in the response of injured tubular cells. We studied the renal and immune phenotypes of miR-146a+/+ and miR-146a−/− mice at 12 months of age, and the results showed that miR-146a−/− mice developed autoimmunity during aging, as demonstrated by circulating antibodies targeting double-stranded DNA and an immune complex-mediated glomerulonephritis associated with a mild renal immune infiltrate. In addition, miR-146a−/− mice showed reduced expression of the transmembrane protein Kim1/Tim1, a key regulator of regulatory B cell (Breg) homeostasis, in the kidney and the immune cells. The numbers of memory B cells and plasmablasts were increased in miR-146a−/− mice compared with the numbers in wild-type mice, whereas Bregs were decreased in number and displayed an altered capacity to produce IL-10. Finally, we showed that miR-146a−/− mice develop an autoimmune syndrome with increasing age, and this syndrome includes immune complex glomerulonephritis, which might be due to altered B cell responses associated with Kim1/Tim1 deficiency. This study unravels a link between miR-146a and Kim1 and identifies miR-146a as a significant player in immune-mediated glomerulonephritis pathogenesis.
Functional connectivity of music-induced analgesia in fibromyalgia
Authors: Pando-Naude Victor , Barrios Fernando A. , Alcauter Sarael , Pasaye Erick H. , Vase Lene , Brattico Elvira , Vuust Peter , Garza-Villarreal Eduardo A. 
Published: October 2019

AbstractListening to self-chosen, pleasant and relaxing music reduces pain in fibromyalgia (FM), a chronic centralized pain condition. However, the neural correlates of this effect are fairly unknown. In our study, we wished to investigate the neural correlates of music-induced analgesia (MIA) in FM patients. To do this, we studied 20 FM patients and 20 matched healthy controls (HC) acquiring rs-fMRI with a 3T MRI scanner, and pain data before and after two 5-min auditory conditions: music and noise. We performed resting state functional connectivity (rs-FC) seed-based correlation analyses (SCA) using pain and analgesia-related ROIs to determine the effects before and after the music intervention in FM and HC, and its correlation with pain reports. We found significant differences in baseline rs-FC between FM and HC. Both groups showed changes in rs-FC after the music condition. FM patients reported MIA that was significantly correlated with rs-FC decrease between the angular gyrus, posterior cingulate cortex and precuneus, and rs-FC increase between amygdala and middle frontal gyrus. These areas are related to autobiographical and limbic processes, and auditory attention, suggesting MIA may arise as a consequence of top-down modulation, probably originated by distraction, relaxation, positive emotion, or a combination of these mechanisms.
Refraction and pupil diameter in 3-year- and 1-month-old children as measured by Spot Vision Screener
Authors: Tatara Shunya , Maeda Fumiatsu , Mizuno Nobuko , Noguchi Atsushi , Yaoeda Kiyoshi , Abe Haruki 
Published: October 2019

AbstractSpot Vision Screener (SVS) can conduct refraction tests for both eyes within a short period. This study aims to evaluate the refraction and pupil diameters of 3-year- and 1-month-old Japanese children using SVS in regular medical checkup. We examined 2438 eyes of 1219 children (age: 3-year- and 1-month) in Fujieda (Shizuoka, Japan) to assess their refraction and pupil diameters and eye-position screening conducted by SVS. SVS successfully measured 1217 children (99.8%). Regarding the right eye refraction, the spherical power was +0.70 ± 0.55 D (median, +0.75 D), and the cylindrical power was −0.67 ± 0.49 D (median, −0.50 D). The pupil diameter of the right eyes was 5.57 ± 0.79 (median, 5.60) mm. we could obtain a large number of basic data for 3-year- and 1-month-old Japanese children. However, refraction and pupil diameter of children were not normally distributed, so careful handling of children’s basic data on the eye is necessary.
Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway
Authors: Davis Shamara E. , Khatua Atanu K. , Popik Waldemar 
Published: October 2019

AbstractAPOL1 alleles G1 and G2 are associated with faster progression to lupus nephritis (LN)-associated end-stage renal disease (LN-ESRD) in African Americans. Increased levels of type I interferons (IFNs) and nucleosome-associated double-stranded DNA (dsDNA) fragments (nsDNA) are the hallmark of this disease. Here, we identify cyclic GMP-AMP synthase (cGAS) and interferon-inducible protein 16 (IFI16) as the major DNA sensors in human immortalized podocytes. We also show that nsDNA triggers the expression of APOL1 and IFNβ via IRF3 activation through the cGAS/IFI16-STING pathway. We demonstrate that maximal APOL1 expression also requires the activation of type I IFN receptor (IFNAR) and STAT1 signaling triggered by IFNβ produced in response to nsDNA, or by exogenous IFNβ. Finally, we show that STAT1 activation is sufficient to upregulate IFI16, subsequently boosting APOL1 expression through a positive feedback mechanism. Collectively, we find that nsDNA-induced APOL1 expression is mediated by both IFNβ-independent and dependent signaling pathways triggered by activation of the cGAS/IFI16-STING pathway. We propose that simultaneous inhibition of STING and the IFNAR-STAT1 pathway may attenuate IFI16 expression, reduce IFI16-cGAS cross-talk, and prevent excessive APOL1 expression in human podocytes in response to nsDNA.
Mode of delivery and pregnancy outcomes in preterm birth: a secondary analysis of the WHO Global and Multi-country Surveys
Authors: Thanh Bao Yen Luong , Lumbiganon Pisake , Pattanittum Porjai , Laopaiboon Malinee , Vogel Joshua P. , Oladapo Olufemi T. , Pileggi-Castro Cynthia , Mori Rintaro , Jayaratne Kapila , Qureshi Zahida , Souza Joã 
Published: October 2019

AbstractMany studies have been conducted to examine whether Caesarean Section (CS) or vaginal birth (VB) was optimal for better maternal and neonatal outcomes in preterm births. However, findings remain unclear. Therefore, this secondary analysis of World Health Organization Global Survey (GS) and Multi-country Survey (MCS) databases was conducted to investigate outcomes of preterm birth by mode of delivery. Our sample were women with singleton neonates (15,471 of 237 facilities from 21 countries in GS; and 15,053 of 239 facilities from 21 countries in MCS) delivered between 22 and <37 weeks of gestation. We assessed association between mode of delivery and pregnancy outcomes in singleton preterm births by multilevel logistic regression adjusted for hierarchical data. The prevalences of women with preterm birth delivered by CS were 31.0% and 36.7% in GS and MCS, respectively. Compared with VB, CS was associated with significantly increased odds of maternal intensive care unit admission, maternal near miss, and neonatal intensive care unit admission but significantly decreased odds of fresh stillbirth, and perinatal death. However, since the information on justification for mode of delivery (MOD) were not available, our results of the potential benefits and harms of CS should be carefully considered when deciding MOD in preterm births.
Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations
Authors: Park Jong Chan , Bae Jung Won , Kim Jieun , Jung Min Whan 
Published: October 2019

AbstractDiverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1–7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration.
Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population
Authors: Chen Yuan Hua , Li Li , Chen Wei , Liu Zhi Bing , Ma Li , Gao Xing Xing , He Jia Liu , Wang Hua , Zhao Mei , Yang Yuan Yuan , Xu De Xiang 
Published: October 2019

AbstractThe association between suboptimal pre-pregnancy body mass index (BMI) and small-for-gestational-age (SGA) infants is not well defined. We investigated the association between pre-pregnancy BMI and the risk of SGA infants in a Chinese population. We performed a cohort study among 12029 mothers with a pregnancy. This cohort consisted of pregnant women that were: normal-weight (62.02%), underweight (17.09%), overweight (17.77%) and obese (3.12%). Birth sizes were reduced in the underweight and obese groups compared with the normal-weight group. Linear regression analysis indicated that birth size was positively associated with BMI in both the underweight and normal-weight groups. Further analysis showed that 12.74% of neonates were SGA infants in the underweight group, higher than 7.43% of neonates reported in the normal-weight group (adjusted RR = 1.92; 95% CI: 1.61, 2.30). Unexpectedly, 17.60% of neonates were SGA infants in the obese group, much higher than the normal-weight group (adjusted RR = 2.17; 95% CI: 1.57, 3.00). Additionally, 18.40% of neonates were large-for-gestational-age (LGA) infants in the obese group, higher than 7.26% of neonates reported in the normal-weight group (adjusted RR = 3.00; 95% CI: 2.21, 4.06). These results suggest that pre-pregnancy underweight increases the risk of SGA infants, whereas obesity increases the risks of not only LGA infants, but also SGA infants.
A spatiotemporal analysis of the food dissemination process and the trophallactic network in the ant Lasius niger
Authors: Planckaert Joffrey , Nicolis Stamatios C. , Deneubourg Jean-Louis , Sueur Cédric , Bles Olivier 
Published: October 2019

AbstractIntranidal food dissemination through trophallactic exchanges is a fundamental issue in social insect colonies but its underlying mechanisms are far from being clear. In light of the division of work, network theory and collective food management we develop a framework to investigate the spatiotemporal dynamics of the trophallactic network in starved Lasius niger ant colonies. Thanks to tracking methods we are able to record spatial locations of the trophallactic interactions in the nest. We highlight quantitative differences between the foragers and non-foragers concerning their contributions, their roles (donor/recipient) and their spatial distributions. Moreover, at the intracaste level, we show interindividual differences in all activities and we characterise their nature. In particular, within each caste, all the individuals have the same probability to start their food exchange activity but their probability to exchange differs after their first trophallactic event. Interestingly, despite the highlighted interindividual differences, the trophallactic network does not differ from a random network.
Screening Different Divalent and Trivalent Metals Containing Binary and Ternary Layered Double Hydroxides for Optimum Phosphate Uptake
Authors: Almojil Sattam Fahad , Othman Mohamed Abdelhalim 
Published: October 2019

AbstractThe elements constituting a layered double hydroxides material provide many alternatives for its optimization. Ten different layered double hydroxides materials with various combinations of Ni, Cu, Zn, Al, Cr, and Fe elements were studied as sorbent materials for phosphate ion. The type of element used in the layered double hydroxides affected the uptake capacity of phosphate. The influence of a specific element alone was not the primary role of enhancing the sorption performance of phosphate ion on the LDHs material. However, using specific two or three elements together is the key to achieve the best result due to synergistic effects. BET surface area of the sorbent showed no correlation with phosphate uptake. From the examined materials, Four layered double hydroxides of Cu-Zn-Cr, Zn-Cr, Ni-Al, and Cu-Ni-Cr showed high phosphate sorption capability. Sorption equilibrium isotherm, reaction kinetics, and desorption of phosphate from the sorbent materials were also investigated.
GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells
Authors: Usui Ryota , Yabe Daisuke , Fauzi Muhammad , Goto Hisanori , Botagarova Ainur , Tokumoto Shinsuke , Tatsuoka Hisato , Tahara Yumiko , Kobayashi Shizuka , Manabe Toshiya , Baba Yoshihiro , Kurosaki Tomohiro , Herrera Pedro Luis , Ogura Masahito , Nagashima Kazuaki , Inagaki Nobuya 
Published: October 2019

AbstractThe long-chain fatty acid receptor GPR40 plays an important role in potentiation of glucose-induced insulin secretion (GIIS) from pancreatic β-cells. Previous studies demonstrated that GPR40 activation enhances Ca2+ release from the endoplasmic reticulum (ER) by activating inositol 1,4,5-triphosphate (IP3) receptors. However, it remains unknown how ER Ca2+ release via the IP3 receptor is linked to GIIS potentiation. Recently, stromal interaction molecule (STIM) 1 was identified as a key regulator of store-operated Ca2+ entry (SOCE), but little is known about its contribution in GPR40 signaling. We show that GPR40-mediated potentiation of GIIS is abolished by knockdown of IP3 receptor 1 (IP3R1), STIM1 or Ca2+-channel Orai1 in insulin-secreting MIN6 cells. STIM1 and Orai1 knockdown significantly impaired SOCE and the increase of intracellular Ca2+ by the GPR40 agonist, fasiglifam. Furthermore, β-cell-specific STIM1 knockout mice showed impaired fasiglifam-mediated GIIS potentiation not only in isolated islets but also in vivo. These results indicate that the IP3R1/STIM1/Orai1 pathway plays an important role in GPR40-mediated SOCE initiation and GIIS potentiation in pancreatic β-cells.
Genes A27L and F13L as Genetic Markers for the Isolation of Recombinant Vaccinia Virus
Authors: Lorenzo María M. , Sánchez-Puig Juana M. , Blasco Rafael 
Published: October 2019

AbstractAfter assembly in the cytosol, some Vaccinia virus particles go through a complex process that leads to virus egress and eventually cell-to-cell transmission. Intracellular particles are fully infectious, and therefore virus mutants lacking essential functions in the exit pathway are unable to form plaques but can multiply intracellularly. We isolated virus mutants in which two of the genes required for virus spread (F13L and A27L) were deleted independently or concurrently. The phenotypes of the mutant viruses were consistent with the need of A27L and F13L for intercellular virus transmission, the effect of the ΔA27L mutation being more severe than that of ΔF13L. Despite their defect in spread, ΔA27L mutant viruses could be expanded by infecting cell cultures at high multiplicity of infection, followed by the release of virions from infected cells by physical means. We developed a novel system for the isolation of recombinant Vaccinia virus in which selection is efficiently achieved by recovering plaque formation capacity after re-introduction of A27L into a ΔA27L virus. This system allowed the insertion of foreign DNA into the viral genome without the use of additional genetic markers. Furthermore, starting with a double mutant (ΔA27L-ΔF13L) virus, A27L selection was used in conjunction with F13L selection to mediate simultaneous dual insertions in the viral genome. This selection system facilitates combined expression of multiple foreign proteins from a single recombinant virus.
Direct determination of phenolic secoiridoids in olive oil by ultra-high performance liquid chromatography-triple quadruple mass spectrometry analysis
Authors: Luque-Muñoz Antonio , Tapia Ruben , Haidour Ali , Justicia Jose , Cuerva Juan M. 
Published: October 2019

AbstractIn recent years, a large number of biological properties and an important role in the organoleptic characteristics of olive oil have been attributed to phenolic secoiridoids, such as oleacein, oleocanthal, oleuropein aglycone and ligstroside aglycone. Consequently, quantifying them is of great interest for the olive oil sector. Currently, there is no consensus in which analytical method must be use to accurately determine these compounds in olive oil, mainly owing to the lack of reference standards for calibration. In this work, analytical standards of phenolic secoiridoids have been used to develop a quantitative and rapid analytical method by UHPLC-MS/MS, in which sample extraction is not carried out. Simple dilutions of the sample with dry tetrahydrofuran and dry acetonitrile were performed before analysing them. It is worth noting that under these conditions the generation of artefacts such as acetals and hemiacetals of the aldehydic forms is highly reduced. The detection and quantification was performed with a Xevo TQS tandem quadrupole mass spectrometer. The method was validated at four concentration levels and finally applied to six samples of extra virgin olive oil.
A new perspective in understanding rainfall from satellites over a complex topographic region of India
Authors: Thakur Manoj Kumar , Kumar T. V. Lakshmi , Koteswara Rao K. , Barbosa Humberto , Rao V. Brahmananda 
Published: October 2019

AbstractPresent study focuses on rainfall over Western Ghats (WG), a complex topographic region (elevation > 500 m) of India to evaluate and to better understand the satellite behavior in contrast with a flat region (FR) (elevation < 500 m) of central India from 1998 to 2016 using the combinatory data sets of TMPA and IMERG (satellite rainfall estimation). The categorical Intra Seasonal Oscillations (ISO) of Indian summer monsoon (ISM) namely, Madden Julian Oscillation (MJO) and Quasi Bi-Weekly Oscillation (QBWO) are tested in satellite and India Meteorological Department (IMD) gridded rainfall data sets to find out the satellite performance. As the accurate estimation of rainfall from satellites over higher elevation zones is challenging, here we propose a new perspective to select the rainfall products of satellite for better comparison with ground measurements. Considering the satellite’s best capability in detecting the cold clouds resulting from deep convection and its coupling with higher-level circulation, we show that the rainfall from satellites yield fruitful comparison with ground measurements when moist static stability, tropical easterly jet is above the climatological values.
Improved Characterisation of Vegetation and Land Surface Seasonal Dynamics in Central Japan with Himawari-8 Hypertemporal Data
Authors: Miura Tomoaki , Nagai Shin , Takeuchi Mika , Ichii Kazuhito , Yoshioka Hiroki 
Published: October 2019

AbstractSpectral vegetation index time series data, such as the normalized difference vegetation index (NDVI), from moderate resolution, polar-orbiting satellite sensors have widely been used for analysis of vegetation seasonal dynamics from regional to global scales. The utility of these datasets is often limited as frequent/persistent cloud occurrences reduce their effective temporal resolution. In this study, we evaluated improvements in capturing vegetation seasonal changes with 10-min resolution NDVI data derived from Advanced Himawari Imager (AHI), one of new-generation geostationary satellite sensors. Our analysis was focused on continuous monitoring sites, representing three major ecosystems in Central Japan, wherein situtime-lapse digital images documenting sky and surface vegetation conditions were available. The very large number of observations available with AHI resulted in improved NDVI temporal signatures that were remarkably similar to those acquired within situspectrometers and captured seasonal changes in vegetation and snow cover conditions in finer detail with more certainty than those obtained from Visible Infrared Imaging Radiometer Suite (VIIRS), one of the latest polar-orbiting satellite sensors. With the ability to capturein situ-quality NDVI temporal signatures, AHI “hypertemporal” data have the potential to improve spring and autumn phenology characterisation as well as the classification of vegetation formations.