bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of a demonstrator repository for individual clinical trial data built upon DSpace
Authors: Tilki Birol , Schulenberg Thomas , Canham Steve , Banzi Rita , Kuchinke Wolfgang , Ohmann Christian 
Published: April 2020

Background: Given the increasing number and heterogeneity of data repositories, an improvement and harmonisation of practice within repositories for clinical trial data is urgently needed. The objective of the study was to develop and evaluate a demonstrator repository, using a widely used repository system (DSpace), and then explore its suitability for providing access to individual participant data (IPD) from clinical research. Methods: After a study of the available options, DSpace (version 6.3) was selected as the software for developing a demonstrator implementation of a repository for clinical trial data. In total, 19 quality criteria were defined, using previous work assessing clinical data repositories as a guide, and the demonstrator implementation was then assessed with respect to those criteria. Results: Generally, the performance of the DSpace demonstrator repository in supporting sensitive personal data such as that from clinical trials was strong, with 14 requirements demonstrated (74%), including the necessary support for metadata and identifiers. Two requirements could not be demonstrated (inability to incorporate de-identification tools in the submission workflow, lack of a self-attestation system) and three requirements were only partially demonstrated (ability to provide links to de-identification tools and requirements, incorporation of a data transfer agreement in system workflow, and capability to offer managed access through application on a case by case basis). Conclusions: Technically, the system was able to support most of the pre-defined requirements, though there are areas where support could be improved. Of course, in a productive repository, appropriate policies and procedures would be needed to direct the use of the available technical features. A technical evaluation should therefore be seen as indicating a system’s potential, rather than being a definite assessment of its suitability. DSpace clearly has considerable potential in this context and appears a suitable base for further exploration of the issues around storing sensitive data.
Confronting Covid-19 by exploring the possibility of vaccinating with live SARS-CoV-2 virus itself, via a route that would reduce the incidence of pulmonary complications
Authors: Joly Etienne 
Published: April 2020

This article proposes that one should explore whether the pulmonary complications of Covid-19 can be reduced or avoided by bypassing the airway entry of the SARS-CoV-2 virus. This could possibly be achieved by injecting live SARS-CoV-2 virus intradermal (ID), subcutaneous, intra-muscular (IM) or intra-peritoneal (IP), or by targeting the virus to the digestive tract. The effectiveness and innocuity of using those various routes could be tested very rapidly in animal models, such as Macaques, Hamsters, Ferrets or Cats. The hope is that these experiments will reveal a route of inoculation that can reliably lead to bona-fide infections, resulting in strong immune responses, with both cellular and serological components, but with much less viral replication in the lungs. This would not only hopefully reduce the incidence of pulmonary complications in the infected subjects, but would also probably reduce the amount of virus released by them via aerosols, and thus reduce the vector of contagiosity that is hardest to control, and that probably leads most effectively to viral replication in the lungs. If those experiments in animal models reveal that one or several routes can be used effectively to reduce pulmonary pathology, a clinical trial could be conducted in human volunteers with very low risk profiles. The ID route should probably be considered as a priority, since it could double-up as a skin test to reveal the immune status of the recipients towards the SARS-CoV-2 virus. The course of action proposed here may possibly provide a way of taking a step ahead of the virus, and if it works as hoped, could help to end the need for confinement within a matter of months, if not weeks.
The Bank of Biological Samples by Seversk Biophysical Research Center
Authors: Takhauova T. , Isubakova D. , Bronikovskaya E. , Tsymbal O. , Khalyuzova M. , Takhauova L. , Karpov A. , Litviakov N. , Milto I. 
Published: April 2020

Purpose: Description of the collection, structure and development dynamics during the period from 2015 to 2019 of the biological material bank of the Seversk Biophysical Research Center, as well as research works carried out using biological material from its collection.
Material and methods: The collection of bank of biological material includes the following types of biological material: venous blood, genomic DNA of white blood cells, cytogenetic suspensions of blood lymphocytes, surgical, biopsy and autopsy material. Biological material was obtained from people exposed to chronic radiation exposure: employees of the nuclear industry and the population permanently residing in the territory located in the area of the nuclear industry.
Results: At present, the collection of the biological material bank contains more than 21,000 samples of biological material obtained from more than 8,000 donors. The collection of bank of biological material is represented by 4 main blocks: biological material of conditionally healthy employees of company of the nuclear industry (Siberian Chemical Combine); biological material of conditionally healthy people permanently residing in the territory located in the area of the nuclear industry enterprise (Seversk); biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with malignant neoplasms and biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with acute myocardial infarction. In the collection of bank of biological material, the proportion of samples of biological material of relatively healthy workers of the Siberian Chemical Combine is 33 %, residents of Seversk — 40.8 %, patients with malignant neoplasms — 22.2 %, patients with acute myocardial infarction — 4 %.
Conclusion: Biological material bank Seversk Biophysical Research Center is unique collection of biological material samples of healthy people and patients with socially significant diseases. A feature of the biological material of the biological material bank is that it is obtained from people who have been exposed to chronic low-intensity radiation exposure and can be used to evaluate its radiogenic effects.
Development of Chemical Samples Preparation Method to Reduce the Lower Limit of Absorbed Dose Assessment by Electron Paramagnetic Resonance Spectrometry
Authors: Pantelkin V. , Zhuravleva V. , Tsoviyanov A. 
Published: April 2020

Purpose: Development of a method of chemical sample preparation to reduce the lower limit of the absorbed dose estimation by EPR spectrometry.
Material and methods: The required number of bone samples was prepared to study the effect of chemical treatment of bone material samples in organic solvents on their EPR spectra. They were subjected to primary treatment to separate the bones from the remains of soft biological tissue, then a dense bone was isolated and its defatting was carried out. Further, a series of parallel experiments on chemical treatment of bone materials in solutions of three organic reducing agents (hydrazine hydrate, ethylenediamine and diethylenetriamine) were done to reduce the magnitude of the native signal when carrying out works on reconstruction of absorbed doses using EPR spectroscopy. Recording of EPR spectra was performed on the ELEXSYS E500 Bruker spectrometer equipped with a high-q cylindrical resonator SHQE. Irradiation of the samples was carried out on the X-ray biological unit RUB RUST-M1.
Results: To reduce the lower limit of detection of the absorbed dose and improve the reliability of the assessment of the absorbed dose using the EPR method, it is required to reduce the native component of the EPR signal without affecting, if possible, the radiation component of the EPR signal. To achieve this effect, a chemical treatment in solutions of amines was proposed, which affect the collagen compounds that present in the bones and which are responsible for the appearance of a native signal in the EPR spectrum. After chemical treatment of bone material samples at 30°C for 30 minutes in a solution of different amines, there was a significant decrease in the amplitude of the native signal, which was: 4 for hydrazine hydrate, 3.3 for diethylenetriamine and 2.1 for ethylenediamine. For bone material samples that were subjected to the proposed chemical treatment in hydrazine hydrate, it is possible to confidently determine the amplitude of the radiation signal by a value of 2–3 Gy against the minimum dose values of 6–8 Gy for bone material samples that were not chemically treated.
Conclusion: It was found that during the chemical treatment there is a significant reduction of the native signal in the spectra of EPR of bone materials, the decrease of the radiation signal at the same time was slightly. Comparison of the results of treatment of bone materials in three organic reducing agents showed that the best results are obtained by the use of hydrazine hydrate at a temperature of 30°C for 30 minutes.
Phase demodulation method based on a dual-identical-chirped-pulse and weak fiber Bragg gratings for quasi-distributed acoustic sensing
Authors: Liang Guanhua , Jiang Junfeng , Liu Kun , Wang Shuang , Xu Tianhua , Chen Wenjie , Ma Zhe , Ding Zhenyang , Zhang Xuezhi , Zhang Yongning , Liu Tiegen 
Published: April 2020

A phase demodulation method for quasi-distributed acoustic sensing (DAS) systems based on a dual-identical-chirped-pulse and weak fiber Bragg gratings (WFBGs) is proposed. Compared to the use of Rayleigh backscattering light in optical fibers, the implementation of WFBGs can contribute to obtaining an optical signal with a higher signal-to-noise ratio (SNR). The dual-identical-chirped-pulse is generated by a time-delay fiber, and the sinusoidal carrier is generated by the interference between the two chirped pulses reflected by adjacent WFBGs. The phase of the sinusoidal carrier represents the dynamic strain change posed on the sensing fiber. Discrete Fourier transform is used to directly retrieve the phase information. The performance of the phase demodulation from interference signals under different sinusoidal carrier frequencies and SNRs is numerically investigated. The piezoelectric transducer is employed to emulate the sound in the experiment to verify the effectiveness of our method. It is shown that the dynamic strain can be well reconstructed at the end of a 101.64 km fiber when the signal SNR is down to 3.234 dB. Our proposed method enables the application of the long-distance sensing in quasi-DAS systems.
MXene-based high-performance all-optical modulators for actively Q-switched pulse generation
Authors: Wu Qing , Wang Yunzheng , Huang Weichun , Wang Cong , Zheng Zheng , Zhang Meng , Zhang Han 
Published: April 2020

Q

-switched fiber lasers are integral tools in science, industry, and medicine due to their advantages of flexibility, compactness, and reliability. All-optical strategies to generate ultrashort pulses have obtained considerable attention as they can modulate the intracavity

Q

factors without employing costly and complex electrically driven devices. Here, we propose a high-performance all-optical modulator for actively

Q

-switched pulse generation based on a microfiber knot resonator deposited with

V
2

CT
x

MXene. Experimental results show that the obtained

Q

-switching pulses exhibit a wide adjustment range of repetition rate from 1 kHz to 20 kHz, a high signal-to-background contrast ratio of

∼
55

dB

, and a narrow pulse width of 8.82 μs, indicating great potentials of providing a simple and viable solution in photonic applications.
Besifovir Dipivoxil Maleate 144-Week Treatment of Chronic Hepatitis B: An Open-Label Extensional Study of a Phase 3 Trial
Authors: Yim Hyung Joon , Kim Won , Ahn Sang Hoon , Yang Jin Mo , Jang Jae Young , Kweon Yong Oh , Cho Yong Kyun , Kim Yoon Jun , Hong Gun Young , Kim Dong Joon , Jung Young Kul , Um Soon Ho , Sohn Joo Hyun , Lee Jin Woo , Park Sung Jae , Lee Byung Seok , Kim Ju Hyun , Kim Hong Soo , Yoon Seung Kew , Kim Moon Young , Lee Kwan Sik , Lim Young Suk , Lee Wan Sik , Han Kwang-Hyub 
Published: April 2020

INTRODUCTION:
Chronic hepatitis B (CHB) remains a major worldwide public health concern. Besifovir dipivoxil maleate (BSV) is a new promising treatment for CHB. However, long-term efficacy and safety have not yet been evaluated. Therefore, the goal of the study is to determine the antiviral efficacy and safety of BSV treatment over a 144-week duration (BSV-BSV) in comparison with those of a sequential treatment with tenofovir disoproxil fumarate (TDF) followed by a 96-week duration BSV administration (TDF-BSV).

METHODS:
After 48 weeks of a double-blind comparison between BSV and TDF treatments, patients continued the open-label BSV study. We evaluated antiviral efficacy and drug safety up to 144 weeks for BSV-BSV and TDF-BSV groups. The primary endpoint was a virological response (hepatitis B virus DNA < 69 IU/mL).

RESULTS:
Among the 197 patients enrolled, 170 and 158 patients entered the second-year and third-year open-label phase extensional study, respectively, whereas 153 patients completed the 144-week follow-up. The virological response rate over the 144-week period was 87.7% and 92.1% in BSV-BSV and TDF-BSV groups, respectively (P = 0.36). The rates of ALT normalization and HBeAg seroconversion were similar between the groups. No drug-resistant mutations to BSV were noted. Bone mineral density and renal function were well preserved in the BSV-BSV group and were significantly improved after switching therapy in TDF-BSV patients.

DISCUSSION:
This extensional study of a phase 3 trial (NCT01937806) suggests that BSV treatment is efficacious and safe for long-term use in treatment-naïve and TDF-experienced patients with CHB.
PENGARUH EDUKASI GIZI DENGAN METODE CERAMAH BERBASIS BAHASA ISYARAT INDONESIA (BISINDO) DAN BOOKLET TERHADAP PENGETAHUAN, SIKAP DAN PRAKTIK GIZI PADA REMAJA TULI SLB DI SEMARANG
Authors: Ayumar Duena Firsta Sridiasti , Margawati Ani , Wijayanti Hartanti Sandi 
Published: April 2020

Latar Belakang : Sebanyak 73,6% siswa remaja Tuli SLB Negeri Semarang tidak mengonsumsi sayur dan buah sesuai anjuran. Edukasi gizi dibutuhkan untuk meningkatkan pengetahuan dan sikap gizi, dimana keduanya memiliki peran dalam perubahan perilaku gizi remaja. Metode ini memanfaatkan indera Tuli yang bekerja dengan optimal yaitu penglihatan. Akan tetapi Tuli memiliki perbendaharaan kata yang cukup terbatas. Metode ceramah yang diterapkan di sekolah (lip-reading) diharapkan meningkatkan kemampuan Tuli menyesuaikan diri dalam kelompok sosial. Namun, penelitian sebelumnya menunjukkan bahwa lip-reading akan lebih optimal apabila dibersamai dengan penggunaan isyarat. Tujuan penelitian ini adalah mengetahui pengaruh edukasi gizi dengan metode ceramah berbasis BISINDO dan booklet terhadap pengetahuan, sikap dan praktik gizi pada remaja Tuli SLB di Semarang.Metode : Jenis penelitian ini adalah Quasi Experimental dengan rancangan pre-post test group design. Subjek penelitian adalah 27 siswa SMP dan SMA LB di Semarang, yang dibagi menjadi kelompok booklet dan ceramah. Edukasi gizi diberikan oleh orang Dengar dengan bantuan juru bahasa isyarat. Hasil : Tidak ada beda pengetahuan (p=0,359), sikap (p=0,063), dan praktik konsumsi sayur dan buah (p=0,692) antara kedua kelompok perlakuan setelah pemberian edukasi gizi. Median nilai pengetahuan mengalami peningkatan. Walaupun kecenderungan hasil penelitian menunjukkan tidak ada perbedaan, nilai kelompok ceramah lebih baik dibandingkan kelompok booklet kecuali pada praktik konsumsi sayur dan buah.Simpulan : Tidak ada pengaruh edukasi gizi dengan metode ceramah berbasis bahasa isyarat Indonesia (BISINDO) dan booklet terhadap pengetahuan, sikap dan praktik konsumsi sayur dan buah pada remaja Tuli SLB di Semarang
HUBUNGAN TINGKAT ASUPAN SENG DAN ZAT BESI DENGAN JUMLAH LEUKOSIT ATLET SEPAK BOLA REMAJA
Authors: Setyarsih Liani , Safitri Iqlima , Susanto Hardhono , Suhartono Suhartono , Fitranti Deny Yudi 
Published: April 2020

Latar belakang: Latihan fisik intensitas tinggi dapat menyebabkan timbulnya stres fisik yang akan menekan sistem imun pada tubuh atlet. Penurunan fungsi sistem imun tersebut akan meningkatkan risiko infeksi dan menurunkan performa atlet. Leukosit adalah komponen yang berperan dalam homeostasis sistem imun. Salah satu faktor yang mempengaruhi sistem imun adalah asupan zat gizi termasuk seng dan zat besi.Tujuan: Untuk mengetahui hubungan tingkat asupan seng dan zat besi dengan jumlah leukosit pada atlet sepak bola remaja.Metode: Penelitian ini merupakan penelitian observasional dengan rancangan Cross sectional. Penelitian dilaksanakan di Sekolah Sepak Bola (SSB) Terang Bangsa Semarang. Jumlah subjek sebanyak 24 atlet remaja dengan metode pengambilan sampel Simple Random Sampling. Data asupan makan diperoleh melalui food recall 24 jam, data aktivitas fisik, kualitas tidur dan kondisi stres psikologis diambil menggunakan kuesioner, dan sampel darah diambil melalui pembuluh darah vena. Data dianalisis menggunakan uji korelasi pearson dan rang spearman.Hasil: Sebanyak 91,7% jumlah leukosit subjek dalam kategori normal. Rerata tingkat asupan seng subjek yaitu 56,22% sedangkan zat besi sebesar 57,7%.Tidak terdapat hubungan signifikan antara tingkat asupan seng dan zat besi dengan jumlah leukosit.Simpulan: Tidak terdapat hubungan signifikan antara tingkat asupan seng dan zat besi dengan jumlah leukosit.
Laboratory Evaluation of the Measuring Capabilities of an Innovative Pressuremeter Probe in Dry Sand
Authors: Lopes dos Santos Alexandre , Dupla Jean-Claude , Canou Jean , Cour Francis , Puech Alain , Droniuc Niculai 
Published: April 2020

Abstract
This article presents the experimental procedures performed in a laboratory to evaluate the measuring capabilities of an innovative monocellular pressuremeter probe. This probe takes advantage of recent technological developments in the domain of inflatable membranes currently applied in the so-called Francis Cour standard tricellular probes, which allow covering an expansion range up to large cavity strains. Those improvements were found to enable increasing the accuracy in the assessment of radial expansion through volume injection in the probe measuring cell at relatively small strain levels without the need of sophisticated punctual measuring arms. Assessing this domain via in situ tests makes up a major contribution to the design of geotechnical structures under cyclic loads, for which the current design practice is mainly developed through laboratory soil tests. To reach this final objective, the probe’s validation program was launched based on pressuremeter tests with unload-reload loops performed in a laboratory calibration chamber and in situ on reference testing sites. This paper focuses on the laboratory testing protocols performed in dry Fontainebleau sand specimens. Shear moduli obtained with the pressuremeter are compared with the expected elementary values for this sand, and it is shown that it was possible to assess sand stiffness at a small strain level using this probe under controlled conditions in a laboratory.
Functional magnetic resonance imaging in primary hyperparathyroidism
Authors: Gazes Yunglin , Liu Minghao , Sum Melissa , Cong Elaine , Kuo Jennifer , Lee James A , Silverberg Shonni , Stern Yaakov , Walker Marcella 
Published: April 2020

Objective
The neurophysiological mechanisms underlying cognitive dysfunction in primary hyperparathyroidism (PHPT) and the brain regions affected are not clear. We assessed neural activation during cognitive testing (matrix reasoning, paired associates, and logical memory) using functional MRI (fMRI) in 23 patients with PHPT and 23 healthy controls. A subset with PHPT was re-assessed 6 months post-parathyroidectomy (PTX).

Design
This is an observational study comparing neural activation by fMRI in patients with PHPT to normative controls. Postmenopausal women were studied at a tertiary referral center.

Results
There were no between-group differences in cognitive task performance. Patients with PHPT had lower neural activation vs controls (max Z = 4.02, all P < 0.01) during matrix reasoning in brain regions involved in executive function (left frontal lobe (k = 57) and right medial frontal gyrus (k = 72)) and motor function (right precentral gyrus (k = 51)). During paired associates (verbal memory), those with PHPT had greater activation in the right inferior parietal lobule (language/mathematical operations; k = 65, P < 0.01). Greater activation in this region bilaterally correlated with higher PTH (k = 96, P < 0.01). Post-PTX, activation decreased during matrix reasoning, but in different regions than those affected pre-PTX.

Conclusions
PHPT is associated with differences in task-related neural activation patterns, but no difference in cognitive performance. While this may indicate compensation to maintain the same cognitive function, there was no clear improvement in neural activation after PTX. Larger, longitudinal studies that include PHPT patients followed without surgery are needed to determine if PTX could prevent worsening of altered neural activation patterns in PHPT.
Projeto Novos Rumos 4.0: pedagogia crítica, metodologias ativas e desenvolvimento humano no ensino de programação básica
Authors: Costa Máximo Jônios , Zavilenski Custódio Karina 
Published: April 2020

Este artigo traz um estudo de caso sobre o Projeto Novos Rumos 4.0, executado em Foz do Iguaçu/PR, pelo Parque Tecnológico Itaipu – PTI-BR, no ano de 2018. A iniciativa capacitou jovens em situação de vulnerabilidade social para a elaboração de softwares utilizando a linguagem de programação Python, por meio de uma formação voltada ao desenvolvimento humano, crítico e técnico. A análise faz uso de um levantamento bibliográfico e documental para referenciar todas as etapas de criação e aplicação da proposta, que formou 30 alunos e buscou desenvolver soluções tecnológicas para problemas enfrentados por entidades do terceiro setor do município. O sucesso alcançado pela ação permite concluir que a elaboração de cursos na área da tecnologia deve passar, necessariamente, pela construção de Projetos Político-Pedagógicos mais aderentes às necessidades reais e práticas de uma sociedade contemporânea que, cada vez mais, faz uso de recursos tecnológicos para superar dificuldades de seu cotidiano. Nesse sentido, o Projeto Novos Rumos 4.0 pode ser uma referência inspiradora e embasadora de políticas públicas educacionais e iniciativas similares em outras localidades.