bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job role and stress influence student movement during postpartum haemorrhage simulation: an exploratory study
Authors: Bican Rachel , Heathcock Jill C , Jedryszek Flora , Debarge Veronique , DeJonckheere Julien , Cybalski M C , Hanssens Sandy 
Published: November 2020

IntroductionPostpartum haemorrhage is the leading cause of maternal death. Healthcare simulations are an educational tool to prepare students for infrequent high-risk emergencies without risking patient safety. Efficiency of movement in the simulation environment is important to minimize the risk of medical error. The purpose of this study was to quantify the movement behaviours of the participants in the simulation and evaluate the relationship between perceived stress and movement.MethodsN=30 students participated in 10 high-fidelity medical simulations using an adult patient simulator experiencing a postpartum haemorrhage. The participants completed the State-Trait Anxiety Inventory prior to the simulation to measure perceived stress. Physical movement behaviours included walking around the simulation, time spent at bedside, arm movements, movements without purpose, looking at charts/vitals and total movement.ResultsMidwife (MW) students spent significantly more time walking (p=0.004) and looking at charts/vitals (p=<0.001) and significantly less time at bedside (p=<0.001) compared to obstetric (OB) students. The MW students demonstrated significantly more total movements compared to the OB students (p=<0.001). There was a significant, moderate, positive relationship between perceived stress and total movement during the simulation for the MW group (r=0.50, p=0.05). There was a trend for a moderate, positive relationship between perceived stress and total movement during the simulation for the OB group (r=0.46, p=0.10).ConclusionsPhysical movement during a simulation varies by job role and is influenced by perceived stress. Improved understanding of physical movement in the simulation environment can improve feedback, training and environmental set-up.
Legislative framework for animal research in the UK
Authors: Dennison Ngaire , Petrie Anja 
Published: November 2020

BackgroundIn 1986, the Animals (Scientific Procedures) Act 1986 (ASPA) replaced the Cruelty to Animals Act 1876, which had up until then protected animals used for ‘vivisection’ in the UK. ASPA itself was amended in 2013 to ensure the full implementation of EU Directive 2010/63/EU, the European Union legislation ‘on the protection of animals used for scientific purposes’, which is considered to be one of the most stringent ethical and welfare standards worldwide. ASPA allows (and controls) legitimate studies using animals in a framework designed to ensure that the potential harms to the animals are justified by the likely benefits of the research. While most veterinary surgeons working in clinical situations do not set out to perform ASPA‐regulated research, a desire to improve clinical outcomes for their patients or for the wider population means that, at times, they may approach or even cross the line from recognised veterinary practice into procedures or activities that require regulation under ASPA, the Veterinary Medicines Regulations (VMR) or other legislation.Aim of the articleThis article provides information on the legislation that exists to protect animals in research and explains how ASPA can affect all veterinary surgeons, and not just those working in research, due to its intersection with the Veterinary Surgeons Act and VMR.
Working while sick in context of regional unemployment: a Europe-wide cross-sectional study
Authors: Reuter Marvin , Dragano Nico , Wahrendorf Morten 
Published: November 2020

BackgroundResearch suggests that areas with high unemployment have lower rates of sickness absence, but the underlying mechanisms remain unclear. One assumption is that when unemployment is high people are more likely to work while being sick (discipline hypothesis). Against this background, we investigate the association between regional unemployment and sickness presenteeism. Second, we study interactions with factors of occupational disadvantage.MethodsWe combined survey data of 20 974 employees collected 2015 in 232 regions from 35 European countries with data on regional unemployment rates obtained from Eurostat. Presenteeism was assessed by the fraction of days worked while ill among all days with illness (presenteeism propensity). To investigate if unemployment was related to presenteeism, we estimated multi-level models (individuals nested in regions) that were adjusted for socio-demographic and occupational covariates to account for compositional differences of the regions.ResultsThe mean presenteeism propensity was 34.8 (SD 40.4), indicating that workers chose presenteeism in 1 out of 3 days with sickness. We found that a change in unemployment by +10 percentage points was associated with a change in presenteeism by +5 percentage points (95% CI 1.2 to 8.6). This relationship was more pronounced among workers with low salary, low skill-level, and industrial and healthcare workers.ConclusionOur results support the assumption that high unemployment elevates presenteeism, and that people in disadvantaged occupations are particularly affected. Policies managing presenteeism should consider the labour market context, particularly during the aftermath of the COVID-19 pandemic.
Reactions to messages about smoking, vaping and COVID-19: two national experiments
Authors: Grummon Anna H , Hall Marissa G , Mitchell Chloe G , Pulido Marlyn , Mendel Sheldon Jennifer , Noar Seth M , Ribisl Kurt M , Brewer Noel T 
Published: November 2020

IntroductionThe pace and scale of the COVID-19 pandemic, coupled with ongoing efforts by health agencies to communicate harms, have created a pressing need for data to inform messaging about smoking, vaping, and COVID-19. We examined reactions to COVID-19 and traditional health harms messages discouraging smoking and vaping.MethodsParticipants were a national convenience sample of 810 US adults recruited online in May 2020. All participated in a smoking message experiment and a vaping message experiment, presented in a random order. In each experiment, participants viewed one message formatted as a Twitter post. The experiments adopted a 3 (traditional health harms of smoking or vaping: three harms, one harm, absent) × 2 (COVID-19 harms: one harm, absent) between-subjects design. Outcomes included perceived message effectiveness (primary) and constructs from the Tobacco Warnings Model (secondary: attention, negative affect, cognitive elaboration, social interactions).ResultsSmoking messages with traditional or COVID-19 harms elicited higher perceived effectiveness for discouraging smoking than control messages without these harms (all p <0.001). However, including both traditional and COVID-19 harms in smoking messages had no benefit beyond including either alone. Smoking messages affected Tobacco Warnings Model constructs and did not elicit more reactance than control messages. Smoking messages also elicited higher perceived effectiveness for discouraging vaping. Including traditional harms in messages about vaping elicited higher perceived effectiveness for discouraging vaping (p <0.05), but including COVID-19 harms did not.ConclusionsMessages linking smoking with COVID-19 may hold promise for discouraging smoking and may have the added benefit of also discouraging vaping.
Effects of combined exercise training and Chlorella intake on vasorelaxation mediated by nitric oxide in aged mice
Authors: Fujie Shumpei , Hasegawa Natsuki , Horii Naoki , Inoue Kenichiro , Uchida Masataka , Iemitsu Motoyuki 
Published: November 2020

Chronic Chlorella intake and aerobic exercise training reduce arterial stiffness and increase circulating nitric oxide (NO) levels, which has beneficial effects. This study aimed to clarify the combined aortic NO-mediated effects of chronic Chlorella intake and aerobic exercise training on endothelial vasorelaxation in aged mice. In this study, 38-week-old male senescence-accelerated mouse prone 1 (SAMP1) mice were divided into aged sedentary control (Con), aerobic exercise training (AT; voluntary wheel running for 12 weeks), Chlorella intake (CH; 0.5% Chlorella powder in normal diet), and AT and CH combined (AT+CH) groups. Endothelium-dependent vasorelaxation by addition of acetylcholine to the isolated mouse aortic rings was significantly higher in the AT, CH, and AT+CH groups than in the Con group; a significantly greater effect was seen in the AT+CH group than in the AT and CH groups. Similarly, plasma and arterial nitrite/nitrate levels and arterial endothelial NO synthase phosphorylation were significantly higher in the AT, CH, and AT+CH groups than in the Con group; the AT+CH group had higher values than the AT and CH groups. Thus, chronic Chlorella intake combined with aerobic exercise training had pronounced effects on endothelial vasorelaxation in aged mice via an additive increase in arterial NO production. Novelty: Endothelium-dependent vasorelaxation was improved by Chlorella intake and exercise. Chlorella intake and exercise increased arterial Akt/eNOS/NO signaling. This combination approach further improved vasorelaxation via arterial NO production.
Membrane proteomic profiling of the heart: past, present, and future
Authors: Lee Shin-Haw , Kim Da Hye , Kuzmanov Uros , Gramolini Anthony O. 
Published: November 2020

Cardiovascular diseases remain the most rapidly rising contributing factor of all-cause mortality and the leading cause of inpatient hospitalization worldwide, with costs exceeding $30 billion annually in North America. Cell surface and membrane-associated proteins play an important role in cardiomyocyte biology and are involved in the pathogenesis of many human heart diseases. In cardiomyocytes, membrane proteins serve as critical signaling receptors, Ca2+ cycling regulators, and electrical propagation regulators, all functioning in concert to maintain spontaneous and synchronous contractions of cardiomyocytes. Membrane proteins are excellent pharmaceutical targets due to their uniquely exposed position within the cell. Perturbations in cardiac membrane protein localization and function have been implicated in the progression and pathogenesis of many heart diseases. However, previous attempts at profiling the cardiac membrane proteome have yielded limited results due to poor technological developments for isolating hydrophobic, low-abundance membrane proteins. Comprehensive mapping and characterization of the cardiac membrane proteome thereby remains incomplete. This review will focus on recent advances in mapping the cardiac membrane proteome and the role of novel cardiac membrane proteins in the healthy and the diseased heart. Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/membrane-proteomic-profiling-of-the-heart/ .
Conditional Relative Survival and Competing Mortality of Patients with Prostate Cancer in Korea: A Nationwide Cohort Study
Authors: Park Jinsung , Han Kyungdo , Shin Dong Wook , Park Sang Hyun , Shin Hyun Bin 
Published: November 2020

Abstract

Background:
Conditional relative survival (CRS) and competing mortality are important survivorship issues after cancer treatment. We aimed to investigate them among patients with prostate cancer treated by various modalities.

Methods:
Using a nationwide population-based database, we calculated 5-year CRS conditioned on 1 through 5 years survival after diagnosis. These rates were stratified by age, sex, socioeconomic status, comorbidities, and treatment received. Cause of death and estimated cause-specific mortality were also described and considered with competing risks.

Results:
A total of 81,773 patients newly diagnosed with primary prostate cancer from 2007 to 2013 were identified. The 5-year CRS was 81.1% at baseline, but increased gradually up to 95.4% at 4 years and exceeded 100% at 5 years after diagnosis, suggesting no excess mortality compared with the general population. However, this pattern differed by treatment received. Patients who underwent androgen deprivation therapy showed 5-year CRS of only 88.4% at 5 years after diagnosis, implying persistent excess mortality. Prostate cancer constituted around one-third of deaths, while other cancers were the main cause of death within &lt;2 years after diagnosis. Noncancer-related deaths, including cardiovascular disease and respiratory disease, increased with time since diagnosis.

Conclusions:
CRS rates for patients with prostate cancer improved over time and exceeded that of the general population at 5 years. Other cancers were the main cause of death in the earlier survivorship phase, and deaths from noncancer causes gradually increased over time.

Impact:
Our findings will help patients and clinicians make evidence-based decisions on the basis of a patient's dynamic risk profile.
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Authors: Boucher Justin C. , Li Gongbo , Kotani Hiroshi , Cabral Maria L. , Morrissey Dylan , Lee Sae Bom , Spitler Kristen , Beatty Nolan J. , Cervantes Estelle V. , Shrestha Bishwas , Yu Bin , Kazi Aslamuzzaman , Wang Xuefeng , Sebti Said M. , Davila Marco L. 
Published: November 2020

Abstract
An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion and shortened persistence. This work led us to hypothesize that by incorporating null mutations of CD28 subdomains (YMNM, PRRP, or PYAP), we could optimize CAR T-cell costimulation and enhance function. In vivo, we found that mice given CAR T cells with only a PYAP CD28 endodomain had a significant survival advantage, with 100% of mice alive after 62 days compared with 50% for mice with an unmutated endodomain. We observed that mutant CAR T cells remained more sensitive to antigen after ex vivo antigen and PD-L1 stimulation, as demonstrated by increased cytokine production. The mutant CAR T cells also had a reduction of exhaustion-related transcription factors and genes such as Nfatc1, Nr42a, and Pdcd1. Our results demonstrated that CAR T cells with a mutant CD28 endodomain have better survival and function. This work allows for the development of enhanced CAR T-cell therapies by optimizing CAR T-cell costimulation.
Myocardial Injury in Severe COVID-19 Compared With Non–COVID-19 Acute Respiratory Distress Syndrome
Authors: Metkus Thomas S. , Sokoll Lori J. , Barth Andreas S. , Czarny Matthew J. , Hays Allison G. , Lowenstein Charles J. , Michos Erin D. , Nolley Eric P. , Post Wendy S. , Resar Jon R. , Thiemann David R. , Trost Jeffrey C. , Hasan Rani K. 
Published: November 2020

Background:
Knowledge gaps remain in the epidemiology and clinical implications of myocardial injury in coronavirus disease 2019 (COVID-19). We aimed to determine the prevalence and outcomes of myocardial injury in severe COVID-19 compared with acute respiratory distress syndrome (ARDS) unrelated to COVID-19.

Methods:
We included intubated patients with COVID-19 from 5 hospitals between March 15 and June 11, 2020, with troponin levels assessed. We compared them with patients from a cohort study of myocardial injury in ARDS and performed survival analysis with primary outcome of in-hospital death associated with myocardial injury. In addition, we performed linear regression to identify clinical factors associated with myocardial injury in COVID-19.

Results:

Of 243 intubated patients with COVID-19, 51% had troponin levels above the upper limit of normal. Chronic kidney disease, lactate, ferritin, and fibrinogen were associated with myocardial injury. Mortality was 22.7% among patients with COVID-19 with troponin under the upper limit of normal and 61.5% for those with troponin levels >10 times the upper limit of normal (
P
<0.001). The association of myocardial injury with mortality was not statistically significant after adjusting for age, sex, and multisystem organ dysfunction. Compared with patients with ARDS without COVID-19, patients with COVID-19 were older and had higher creatinine levels and less favorable vital signs. After adjustment, COVID-19–related ARDS was associated with lower odds of myocardial injury compared with non–COVID-19–related ARDS (odds ratio, 0.55 [95% CI, 0.36–0.84];
P
=0.005).

Conclusions:
Myocardial injury in severe COVID-19 is a function of baseline comorbidities, advanced age, and multisystem organ dysfunction, similar to traditional ARDS. The adverse prognosis of myocardial injury in COVID-19 relates largely to multisystem organ involvement and critical illness.
Long‐Term Effectiveness and Safety of Initiating Statin Therapy After Index Revascularization In Patients With Peripheral Arterial Occlusive Disease
Authors: Peters Frederik , Kuchenbecker Jenny , Kreutzburg Thea , Marschall Ursula , Debus E. Sebastian , Behrendt Christian‐Alexander 
Published: November 2020

Background
An increasing number of patients with a peripheral arterial occlusive disease were put on statins during the past years. This study assessed whether statin therapy was effective and safe for these new users.

Methods and Results
Using health insurance claims data from Germany’s second‐largest insurance fund, BARMER, we identified patients with peripheral arterial occlusive disease who had index revascularization between 2008 and 2018 without prior statin therapy. We compared patients with and without statin therapy in addition to antithrombotics during the first quarter after discharge (new users versus nonusers). Outcomes were all‐cause mortality, cardiovascular events, and incident major amputation for effectiveness and incident diabetes mellitus and incident myopathy for safety. Propensity score matching was used to balance the study groups. All analyses were stratified into patients with chronic limb‐threatening ischemia and intermittent claudication. A total of 22 208 patients (mean age 71.1 years and 50.3% women) were included in the study. In 10 922 matched patients, statin initiation was associated with lower all‐cause mortality (chronic limb‐threatening ischemia: hazard ratio [HR], 0.75 [95% CI, 0.68–0.84]; intermittent claudication: HR, 0.80 [95% CI, 0.70–0.92]), lower risk of major amputation in patients with chronic limb‐threatening ischemia (HR, 0.73; 95% CI, 0.58–0.93) and lower risk of cardiovascular events (hazard ratio, 0.80; 95% CI, 0.70–0.92) in patients with intermittent claudication during 5 years of follow‐up. Safety outcomes did not differ among the study groups.

Conclusions
Initiating statin therapy in patients with peripheral arterial occlusive disease after index revascularization is efficient and safe with an effect size comparable to earlier studies. Awareness campaigns for evidence‐based optimal pharmacological treatment among patients are recommended.
Tradizione e prassi editoriale dei testi etiopici: un breve sguardo d’insieme
Authors: Bausi Alessandro 
Published: November 2020

Abstract
The tradition of Ethiopic texts, although characterized by a particular temporal articulation of its own that distinguishes texts from Antiquity and Late Antiquity and texts of the medieval age, has been and is the object of study of a philology that shares the history and paradigms of the other philologies of the Christian East; like these, throughout the course of the twentieth century and almost without exception, the criterion unwittingly selected and adopted as the norm of the ‘base manuscript’ dominated. Unlike the other philologies, however, in the last two decades of the twentieth century, the Italian school of Ethiopian studies renewed by Paolo Marrassini and eventually appreciated also in Europe and in Ethiopia, has largely applied the Neo-Lachmannian reconstructive stemmatic method to Ethiopic texts. Even in the absence of universal consensus, this method is still the only one that has prompted a theoretical-methodological reflection on the phenomenology of Ethiopic texts.
The Megacity Lagos and Three Decades of Urban Heat Island Growth
Authors: Bassett R. , Young P. J. , Blair G. S. , Samreen F. , Simm W. 
Published: November 2020

AbstractLagos, Nigeria, is rapidly urbanizing and is one of the fastest-growing cities in the world, with a population that is increasing at almost 500 000 people per year. Yet the impacts on Lagos’s local climate via its urban heat island (UHI) have not been well explored. Considering that the tropics already have year-round high temperatures and humidity, small changes are very likely to tip these regions over heat-health thresholds. Using a well-established model, but with an extended investigation of uncertainty, we explore the impact of Lagos’s recent urbanization on its UHI. Following a multiphysics evaluation, our simulations, against the background of an unusually warm period in February 2016 (during which temperatures regularly exceeded 36°C), show a 0.44°C ensemble-time-mean increase in nighttime UHI intensity between 1984 and 2016. The true scale of the impact is seen spatially as the area over which ensemble-time-mean UHIs exceed 1°C was found to increase steeply from 254 km2 in 1984 to 1572 km2 in 2016. The rate of warming within Lagos will undoubtedly have a high impact because of the size of the population (12+ million) already at risk from excess heat. Significant warming and modifications to atmospheric boundary layer heights are also found in rural areas downwind, directly caused by the city. However, there is limited long-term climate monitoring in Lagos or many similarly expanding cities, particularly in the tropics. As such, our modeling can only be an indication of this impact of urbanization, and we highlight the urgent need to deploy instrumentation.
Seasonal Precipitation Predictability for the Northern Hemisphere Using Concurrent and Preseason Atmospheric Water Vapor Transport and Sea Surface Temperature
Authors: Gao Shida , Liu Pan , Lall Upmanu 
Published: November 2020

AbstractIntegrated atmospheric water vapor transport (IVT) is a determinant of global precipitation. In this paper, using the CERA-20C climate reanalysis dataset, we explore three questions in Northern Hemisphere precipitation for four seasons: 1) What is the covariability between the leading spatiotemporal modes of seasonal sea surface temperature (SST), the seasonal IVT, and the seasonal precipitation for the Northern Hemisphere? 2) How well can the leading spatial modes of seasonal precipitation be reconstructed from the leading modes of IVT and SST for the same season? 3) How well can the leading modes of precipitation for the next season be predicted from the leading modes of the current season’s SST and IVT? Wavelet analyses identify covariation in the leading modes of seasonal precipitation and those of IVT and SST in the 2–8-yr band, with the highest amplitude in the March–May (MAM) season, and provide a firm physical explanation for the potential predictability. We find that a subset of the 10 leading principal components of the seasonal IVT and SST fields has significant trends in connections with seasonal precipitation modes, and provides an accurate statistical concurrent reconstruction and one-season-ahead forecast of the leading seasonal precipitation modes, thus providing a pathway to improving the understanding and prediction of precipitation extremes in the context of climate change attribution, seasonal and longer prediction, and climate change scenarios. The same-season reconstruction model can explain 76% of the variance, and the next-season forecast model can explain 58% variance of hemispheric precipitation on average.