bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of long noncoding RNA maternally expressed gene 3 in acute promyelocytic leukemia
Authors: Jiang Mei , Wang Qiufeng , Yu Ganquan , Wan Jinghua , Liu Shuyuan , Zhang Zhanglin , Le Aiping 
Published: December 2020

AbstractIntroductionLong noncoding RNA maternally expressed gene 3 (MEG3) expression was significantly decreased in acute myeloid leukemia (AML). However, its expression and clinical significance in acute promyelocytic leukemia (APL) remain unclear. Thus, the present study aimed to investigate the expression of MEG3 in APL and explore its clinical value.MethodsA total of 287 AML patients derived from The Cancer Genome Atlas (TCGA) and Vizome database were enrolled. A development and validation cohort, including APL, AML with AML1/ETO, and other types of AML patients and disease controls, from the First Affiliated Hospital of Nanchang University, were also enrolled in this study. The correlation between MEG3 expression and the clinicopathological features in APL was investigated. The diagnostic values of MEG3 expression in APL were analyzed by receiver operating characteristic (ROC) curves.ResultIn the development set, MEG3 expression was significantly increased in APL than AML with AML1/ETO, other types of AML, and disease controls, which was consistent with the results from the database analysis. MEG3 expression in APL was associated with age (P = .0053) but did not correlate with other clinicopathological features (P > .05). ROC curve analysis in the development set and diagnostic test analysis in the validation set suggested that MEG3 expression has a significant value in the diagnosis of APL. Furthermore, the expression of MEG3 decreased during the follow‐up of patients with negative PML/RARα fusion gene.ConclusionMEG3 serves as a novel marker for the diagnosis of APL, evaluates the curative effect, and provides a novel direction for further research.
Metaheuristics for the work‐troops scheduling problem
Authors: Barbalho Thiago Jobson , Santos Andréa Cynthia , Aloise Dario José 
Published: December 2020

AbstractAfter disasters, such as in the aftermath of a major earthquake, the road network can be blocked by debris from collapsed buildings, impacting accessibility to the affected population. In addition, people move and assemble in various points of the city. In this context, road network accessibility becomes an important issue for logistics operations responsible for the relief and the distribution of supplies to the affected population. We propose metaheuristics for the multi‐period Work‐troops Scheduling Problem (WSP), extending a contribution from the literature. The WSP is an NP‐hard problem. This study brings several contributions to the WSP such as a dedicated local search and two metaheuristics: a Greedy Randomized Adaptive Search procedure and an Iterated Local Search. Results are performed on theoretical instances, and on a realistic instance of Port‐au‐Prince city in Haïti after the 2010 earthquake, where the problem has 16,660 vertices and 19,866 routes representing the urban network, and more than 500 blocked roads. The method developed improved the results from the literature and the results indicate its robustness. Moreover, the best‐known results for the case of the Haïti instances are presented in this study.
Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails
Authors: Yuan Xi , Shen Jie , Chen Li , Wang Liang , Yan Qing , Zhang Jiaping 
Published: December 2020

AbstractTo evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta‐analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta‐analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed‐effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.
Good dielectric performance and broadband dielectric polarization in Ag, Nb co‐doped TiO2
Authors: Liang Pengfei , Zhu Jie , Wu Di , Peng Hui , Chao Xiaolian , Yang Zupei 
Published: December 2020

AbstractDue to the demand of miniaturization and integration for ceramic capacitors in electronic components market, TiO2‐based ceramics with colossal permittivity has become a research hotspot in recent years. In this work, we report that Ag+/Nb5+ co‐doped (Ag1/4Nb3/4)xTi1−xO2 (ANTOx) ceramics with colossal permittivity over a wide frequency and temperature range were successfully prepared by a traditional solid–state method. Notably, compositions of ANTO0.005 and ANTO0.01 respectively exhibit both low dielectric loss (0.040 and 0.050 at 1 kHz), high dielectric permittivity (9.2 × 103 and 1.6 × 104 at 1 kHz), and good thermal stability, which satisfy the requirements for the temperature range of application of X9R and X8R ceramic capacitors, respectively. The origin of the dielectric behavior was attributed to five dielectric relaxation phenomena, i.e., localized carriers' hopping, electron–pinned defect–dipoles, interfacial polarization, and oxygen vacancies ionization and diffusion, as suggested by dielectric temperature spectra and valence state analysis via XPS; wherein, electron‐pinned defect–dipoles and internal barrier layer capacitance are believed to be the main causes for the giant dielectric permittivity in ANTOx ceramics.
Can permanent His bundle pacing be safely started by operators new to this technique? Data from a multicenter registry
Authors: Chaumont Corentin , Auquier Nathanael , Milhem Antoine , Mirolo Adrian , Al Arnaout Alain , Popescu Elena , Viart Guillaume , Godin Bénédicte , Gillibert André , Savouré Arnaud , Eltchaninoff Hélène , Anselme Frédéric 
Published: December 2020

AbstractBackgroundRight ventricular pacing (RVP) induces ventricular asynchrony in patients with normal QRS and increases the risk of heart failure and atrial fibrillation in long term. His bundle pacing (HBP) is a physiological alternative to RVP, and could overcome its drawbacks. Recent studies assessed the feasibility and safety of HBP in expert centers with a vast experience of this technique. These results may not apply to less experienced centers. We aim to evaluate the feasibility and safety of permanent HBP performed by physicians who are new to this technique.MethodsWe included all patients who underwent pacemaker implantation with attempt of HBP in three hospitals between September 2017 and January 2020. Indication for HBP was left to operators' discretion. All the operators were new for HBP. His bundle (HB) electrical parameters were recorded at implant, 3‐ and 12‐month follow‐up.ResultsHBP was successful in 141 of 170 patients (82.9%); selective HBP was obtained in 96 patients and nonselective HBP in 45. The mean procedure and fluoroscopy durations were 67.0 ± 28.8 min, and 7.3 ± 8.1 min (3.1 ± 4.1 Gy·cm2), respectively. The mean HB paced QRS duration was 106 ± 18 ms. The mean HB capture threshold was 1.29 ± 0.77 V and did not increase at 3‐ and 12‐month follow‐up. The ventricular lead revision was required in five patients. Our results showed a rapid technical learning allowing a high procedure success rate (89.8%) after 15 procedures.ConclusionHBP performed by operators new to this technique appeared feasible and safe. This should encourage HBP to be performed in patients expected to experience high RVP burden.
Under‐recognition of pediatric hypertension diagnosis: Examination of 1 year of visits to community health centers
Authors: Moin Anoosh , Mohanty Nivedita , Tedla Yacob G. , Carroll Allison J. , Padilla Roxane , Langman Craig B. , Smith Justin D. 
Published: December 2020

AbstractPediatric hypertension is associated with significant target organ damage in children and cardiovascular morbidity in adulthood. Appropriate diagnosis and management per guideline recommendations are inconsistent. In this study, we determined the proportion of missed diagnosis of hypertension and prehypertension and appropriate follow‐up in pediatric patients, stratified by sex, age, race/ethnicity, and weight status. Based on the electronic health record (EHR) data from eight federally qualified health centers, among 62,982 children aged 3 to 18 years, 6233 (10%) had at least one abnormal blood pressure (BP) measurement over twelve months. Among those children whose recorded BPs met the criteria for prehypertension (N = 6178), 14.6% had a diagnosis in the EHR. These children were more likely to be White and have obesity compared with children who met the criteria but were not diagnosed with prehypertension. Among those who met the criteria for hypertension (N = 55), 41.8% had a diagnosis of hypertension in the EHR. Being diagnosed with hypertension was not associated with any examined patient characteristics. Over eleven months, 2837 children had BP ≥ 95th percentile on ≥ 1 visit. Only 13% had guideline‐adherent follow‐up within 1 month and were more likely to be older, female, and of Hispanic ethnicity or “other” race. Over six months, 2902 children had BP ≥ 90th percentile on one visit. 41% had guideline‐adherent follow‐up within 6 months and were more likely to be older, of either White, Hispanic, Asian race, or Hispanic ethnicity. In a community‐based setting, pediatric hypertension and prehypertension were persistently underdiagnosed with low adherence to recommended follow‐up.
Factors associated with Diaphorina citri immigration into commercial citrus orchards in São Paulo State, Brazil
Authors: Zorzenon Fernando P. F. , Tomaseto Arthur F. , Daugherty Matthew P. , Lopes João R. S. , Miranda Marcelo P. 
Published: December 2020

AbstractSeasonality often influences multiple aspects of vector‐borne plant diseases. With respect to the management of plant disease vectors, an understanding of the factors driving seasonal changes in vector flight activity may improve management outcomes by facilitating more proactive application of control measures. One of the most challenging issues for citrus Huanglongbing management is to forecast when disease primary spread by bacteriliferous Diaphorina citri will occur. We monitored the temporal patterns of immigrating psyllids, using upwards of 1,200 traps spread among 9 citrus farms and checked on a weekly basis over 4 years. This dataset was analysed with a set of hierarchical models to estimate the effect of climatic variables on citrus foliage production (i.e. flush), and effects of climatic variables and citrus foliage dynamics on D. citri catches over the season. The results showed substantial seasonal variability in immigrating D. citri abundance, with the critical dispersal/migration period occurring between end of winter and spring. During this period, 65% of the total psyllids were collected on sticky traps. Seasonality of immigrating D. citri coincided with changes in certain climate variables, with negative effects of humidity and daily maximum temperatures, and a positive effect of rainfall amount in prior weeks. Maximum temperature and both daily minimum temperature and rainfall during prior weeks were also associated with new citrus flush production, which itself was positively related to immigrating D. citri abundance. Based on these results, citrus growers should be aware and intensify the frequency of psyllid control tactics (i.e. insecticide and/or kaolin sprays) during this period in order to prevent Ca. L. asiaticus transmission. These results are an important step towards developing the predictive framework needed to refine D. citri and huanglongbing management.
Modeling and optimization of drying conditions of dog rose for preparation of a functional tea
Authors: Pashazadeh Hojjat , Zannou Oscar , Koca Ilkay 
Published: December 2020

AbstractDog rose (Rosa caninaL.) is a rosehip used for domestic and industrial purposes. It has great antioxidant compounds such as lycopene and phenolic compounds. In the present study, technological processing was investigated to formulate a functional tea with great nutraceutical compounds. The drying conditions were optimized to have maximum antioxidant properties. The optimum conditions were 68°C and 1 m s−1, providing the values of 40751.17 mg GAE/kg, 14.17 mg EGC E/100 g, 278.87 mmol TE/g, 44.62 mmol ISE/g, 3051.36 mg/kg, and 13.28 mg/kg for TPC, TFC, DPPH radical scavenging, FRAP, ascorbic acid, and lycopene, respectively. Midilli model described well the drying behavior of Dog rose and, Peleg, Weibull and Vega‐galves models predicted well the rehydration kinetics. A two‐factor and central composite design was applied to evaluate the effects of decoction time and solid‐to‐liquid ratio. At the optimal conditions, the Dog rose tea had 98141.28 mg GAE/kg, 2720.66 mg EGC E/100 g, 8616.57 mmol TE/g, 728.24 mmol ISE/g; and 3,358 for TPC, TFC, DPPH radical scavenging, FRAP, and ascorbic acid content, respectively. The findings showed that Dog rose fruit is a great source of nutraceutical compounds and a potential industrial product.Practical applicationThe drying conditions to have a dried fruit with high antioxidant properties were determined. The dried Dog rose fruit is stable for long storage period and be afforded in off‐seasons. Optimization and mathematical models were successfully applied to determine the optimum drying conditions and to predict the drying and rehydration kinetics, respectively. Midilli model was the most fitted model to predict the drying kinetics, while, Peleg, Vegas‐gálves and Weibull models depicted better the rehydration kinetics at 20, 40, and 60°C. The dried fruit can be used in food, cosmetic, and pharmaceutical industries for many purposes. A functional fruit tea was formulated and optimized for its nutraceutical properties. This tea is a functional food used as a natural preventive remedy for flu, cancer, anemia, cardiovascular diseases and diabetes as well.
Use of phenomenological rheology methods to analyze the viscoelastic properties of bee honeys
Authors: Orczykowska Magdalena , Olejnik Tomasz P. , Rosicka‐Kaczmarek Justyna , Miśkiewicz Karolina , Kowalska Gabriela 
Published: December 2020

AbstractThe purpose of this study was to analyze the influence of temperature on the rheological properties of natural Polish honeys. We used phenomenological rheology methods to assess the elasticity and crosslinking ability of the structure of the honeys, as well as to investigate both the possibility of slowing down the aging process and the damping factor of the network oscillations. Dynamic tests of buckwheat, clover, and honeydew honeys were performed by measuring the storage modulus (G′) and loss modulus (G′′) in the angular frequency range of 0.1 rad/s to 100 rad/s across a wide temperature range (−20°C to 70°C). The honeys were found to have a typical structure for viscoelastic quasi‐solid bodies, with a tendency to form a pseudo‐gel. Phenomenological rheology methods were shown to be suitable for assessing changes in the structures of bioproducts, such as bee honeys.Practical ApplicationsThe presence of so many different chemical compounds in honey makes it a material with heterogeneous and variable molecular structure, which depends on the way it is stored and the individual operations performed during processing (liquefaction, pumping, transport, etc.). Temperature is among many factors influencing the properties and structure of honey during technological operations. Phenomenological rheology methods have been shown to be an appropriate tool for assessing changes in the structure of bioproducts such as bee honeys. Their use makes it possible to determine changes in the rheological parameters of the tested honeys, resulting from temperature changes during storage or transport. The analysis of the mechanical state of the structure honeys carried out this way can be useful to properly design (predict) the course of processing processes of such a medium, which is particularly important from the point of view of utility characteristics and physicochemical properties of the final product obtained with the use of honey.
COVID‐19 Infection Prevention and Control Adherence in Long‐Term Care Facilities, Atlanta, Georgia
Authors: Telford Carson T. , Bystrom Cyndra , Fox Teresa , Holland David P. , Wiggins‐Benn Sherry , Mandani Anjum , McCloud Meshell , Shah Sarita 
Published: December 2020

Background/ObjectiveRecommendations for infection prevention and control (IPC) of COVID‐19 in long‐term care settings were developed based on limited understanding of COVID‐19 and should be evaluated to determine their efficacy in reducing transmission among high‐risk populations.Design and SettingSite visits to 24 long‐term care facilities (LTCFs) in Fulton County, Georgia, were conducted between June and July 2020 to assess adherence to current guidelines, provide real‐time feedback on potential weaknesses, and identify specific indicators whose implementation or lack thereof was associated with higher or lower prevalence of COVID‐19.ParticipantsTwenty‐four LTCFs were visited, representing 2,580 LTCF residents, among whom 1,004 (39%) were infected with COVID‐19.MeasurementsOverall IPC adherence in LTCFs was analyzed for 33 key indicators across five categories: Hand Hygiene, Disinfection, Social Distancing, PPE, and Symptom Screening. Facilities were divided into Higher‐ and Lower‐prevalence groups based on cumulative COVID‐19 infection prevalence to determine differences in IPC implementation.ResultsIPC implementation was lowest in the Disinfection category (32%) and highest in the Symptom Screening category (74%). Significant differences in IPC implementation between the Higher‐ and Lower‐prevalence groups were observed in the Social Distancing category (Higher‐prevalence group 54% vs Lower‐prevalence group 74%, P < .01) and the PPE category (Higher‐prevalence group 41% vs Lower‐prevalence group 72%, P < .01).ConclusionLTCFs with lower COVID‐19 prevalence among residents had significantly greater implementation of IPC recommendations compared to those with higher COVID‐19 prevalence, suggesting the utility in adhering to current guidelines to reduce transmission in this vulnerable population.
Isolation and characterization of exosomes from adipose tissue‐derived mesenchymal stem cells
Authors: González‐Cubero Elsa , González‐Fernández María Luisa , Gutiérrez‐Velasco Laura , Navarro‐Ramírez Eliezer , Villar‐Suárez Vega 
Published: December 2020

AbstractMesenchymal stem cells (MSCs) are the subject of intense research as they are a potential therapeutic tool for several clinical applications. The new MSCs action models are focused on the use of MSC‐derived secretome which contains several growth factors, cytokines, microRNAs, and extracellular vesicles such as exosomes. Exosomes have recently emerged as a component with great potential involved as mediators in cellular communication. The isolation and identification of exosomes has made it possible for them to be used in cell‐free therapies. The purposes of this study are: (i) to detect exosomes released into adipose‐derived MSC conditioned cell culture medium, (ii) to identify exosome morphology, and (iii) to carry out a complete characterization of said exosomes. Moreover, it is aimed at determining which method for exosome isolation would be best to use. Precipitation has been identified as a highly useful method of exosome isolation since it provides higher efficiency and purity values than other methods. A broad characterization of the exosomes present in the MSC‐conditioned medium was also carried out. This work fills a gap in the existing literature on bioactive molecules which have attracted a great deal of interest due to their potential use in cellular therapies.
Exploring the macrostructural anatomy of dendrochirotid sea cucumber’s (Echinodermata) calcareous rings under micro‐computed tomography and its bearing on phylogeny
Authors: Martins Luciana , Souto Camilla , Tavares Marcos 
Published: December 2020

AbstractDespite descending from heavily calcified ancestors, the holothuroid skeleton is fully internal and composed of microscopic ossicles and a ring of plates bound by connective tissue, the calcareous ring. The calcareous ring exhibits a complex and poorly understood morphology; as a result, establishing unambiguous homology statements about its macrostructure has been challenging and phylogenetic studies have had to simplify this important structure. Here, we provide the first broad comparative study of Dendrochirotida calcareous rings using micro‐computed tomography (μCT). A detailed description of the three‐dimensional macrostructure of the calcareous ring of 10 sea cucumber species, including rare and type specimens, is presented. The structures observed were highly variable at the subfamily level, especially at the point of tissue attachment. The relationship between the calcareous ring and its associated organs, and their functional morphology are discussed. To aid future phylogenetic studies, we listed 22 characters and performed a preliminary cladistic analysis. The topology obtained supports the idea that the simple, cucumariid ring is ancestral to the mosaic‐like phyllophorid ring; however, it did not support the monophyly of the cucumariids. It also did not support the family Sclerodactylidae, which was described based on the ring morphology. Differently from the dermal ossicles, which are highly homoplastic, the general homoplasy index of the calcareous ring characters was relatively low. This result highlights the importance of this structure for phylogenetic inference. Unfortunately, time since collection, rough collection methods and fixation can damage the skeleton, and the calcareous ring is often overlooked in taxonomic descriptions. The data presented here will improve our understanding of holothuroid relationships and facilitate studies on holothuroid functional morphology and biomechanics.