bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green coffee infusion: An endodontic elixir
Authors: Chondamma Tanya , Cariappa Ponappa Muckatira , Ponnappa K. C. , Shashidara R. 
Published: December 2024

Context:
Irrigation is a critical component in accessing the labyrinth of the pulp space. Although traditional irrigants such as sodium hypochlorite (NaOCl) are widely employed, they exhibit several limitations, including cytotoxicity and complete microbial eradication. In contrast, phytochemicals derived from plants, including coffee, present promising alternatives due to their established antimicrobial properties.

Aims:
The aim of this study was to evaluate the efficacy of intracanal irrigants derived from locally cultivated Coffea arabica and Coffea canephora (Robusta) varieties, both recognized for their antimicrobial attributes.

Subjects and Methods:
A total of 70 extracted human single-rooted teeth were prepared. Coffee extracts were prepared through a decoction method, and the minimum inhibitory concentrations (MICs) of these extracts were determined using microbroth dilution assays. Microbial growth was quantitatively assessed at predetermined intervals.

Results:
Green Robusta extracts exhibited antimicrobial effectiveness at lower concentrations of 25% and 12.5%. All coffee extract groups demonstrated substantial reductions in microbial counts compared to the negative control, with Robusta extracts proving particularly efficacious. Notably, the Robusta green 12.5% extract exhibited sustained antimicrobial efficacy, suggesting its potential as an alternative to NaOCl.

Conclusions:
The findings of this study suggest a novel approach to improving endodontic therapy outcomes through the utilization of coffee extracts, potentially enhancing dental health.
Endocrown-retained fixed partial dentures: Revolutionizing tooth restoration or risky business? A finite element study
Authors: Muthukumar Nivedha , Natarajan Parthasarathy , Kumar Seenivasan Madhan , Natarajan Shanmuganathan 
Published: December 2024

Aim:
This study aimed to compare the biomechanical performance of endocrown-retained and post-and-core-retained fixed partial dentures (FPDs), focusing on stress distribution, tensile, and shear stress.

Materials and Methods:
Finite element analysis was used to simulate occlusal loading on two FPD designs: endocrown-retained zirconia and post-and-core-retained zirconia which were subjected to a simulated occlusal load of 150 N. Stress distribution was analyzed using von Mises stress, tensile stress, and shear stress. Material properties for zirconia, resin cement, enamel, dentin, bone, Periodontal ligament (PDL), and fiber post were incorporated.

Results:
The endocrown design showed lower von Mises stress (176.35 MPa) than the post-and-core design (298.29 MPa). It also had lower shear stress at the cement interface and reduced stress on abutment teeth.

Conclusion:
Endocrown-retained FPDs provide better stress distribution and structural integrity, offering a reliable, minimally invasive option for restoring endodontically treated molars.

Clinical Significance:
Endocrown retained 3-unit fixed partial denture can be a promising alternative to the fiber-post retained FPD for restoring molars with extensive tooth loss.
Probing the Clinical, Laboratory, and Sociodemographic Factors Associated with Malaria: A Case-Control Study
Authors: Upadhyay Ritesh , Dhumale Annasaheb J. , Dehariya Chanchlesh , Waghmare Renu , Rangari Amit 
Published: December 2024

ABSTRACT

Background:
The National Malaria Elimination Program (NMEP) has helped reduce the mortality from malaria in India, and there are alarmingly high mortality rates from anemia in certain geographical regions.

Aim:
To assess the clinical, laboratory, and sociodemographic factors associated with malaria from P. falciparum and P. vivax.

Methods:
This retrospective record-based clinical study subjects with malaria were further divided into P. vivax and P. falciparum cases. In all the cases, the clinical, laboratory, and sociodemographic factors were assessed. Data gathered were analyzed statistically.

Results:
During the study period, 222 cases of malaria were assessed where 22.52% (n = 50) and 74.48% (n = 172) cases were due to P. falciparum and P. vivax, respectively. Hepatomegaly was common in P. falciparum cases and splenomegaly in P. vivax cases. Thrombocytopenia was seen in 58.1% (n = 100) and 72% (n = 36) subjects with P. vivax and P. falciparum cases. No significant difference was seen in other laboratory parameters.

Conclusions:
Clinical, laboratory, and sociodemographic factors associated with malaria from P. falciparum and P. vivax have no statistically significant difference.
Personalized Nursing and Precision Nursing: A Concept of the Future of the Health Model
Authors: Besharati Saeid , Kalaleh Azam Rahimzadeh 
Published: December 2024

Abstract
The advent of the biomedical data era has significantly propelled the advancement of personalized nursing and precision nursing (2PN). By utilizing comprehensive patient data, 2PN facilitates early screening, health management, and timely interventions, thereby enhancing disease prognosis and population health outcomes efficiently. This literature review identifies relevant electronic publications from databases such as Google Scholar, PubMed, Web of Science, Scopus, and ERIC, covering articles from 2019 to 2024. The keywords included “precision nursing,” “personalized nursing,” “precision care,” and “nursing health care” from Medical Subject Headings (MeSH). After applying inclusion and exclusion criteria, 13 articles were analyzed. The study underscores the necessity of interdisciplinary collaboration to thoroughly integrate 2PN concepts into nursing practice and highlights the pivotal role of biomedical big data in advancing 2PN. Various dimensions of 2PN were explored, demonstrating its significance in clinical practice, research, education, and nursing management. The findings support the development of strategic health plans aimed at improving individual, family, and societal health.
Identification of Putative Toxicophores in Annona muricata Phytochemical and their Hepatotoxic Potential
Authors: Castro Alexander Carlo S. , Austria Brianne M. , Nas John Sylvester B. 
Published: December 2024

Abstract

BACKGROUND:
Traditional herbal medicine is popular in Southeast and East Asia, particularly in the Philippines. Among the most widely utilized herbal remedies in this region is soursop or Annona muricata. Soursop is known for its numerous therapeutic properties, including anti-inflammatory, antiparasitic, antipyretic, antibacterial, and even anticancer activities. However, the wide availability and affordability of soursop, coupled with its promising medicinal properties, may lead to potential misuse or overuse, particularly among terminally ill patients. We hypothesize that the phytochemicals in the fruit pulp of A. muricata, which contain toxicophores, may contribute to its potential hepatotoxic effects. This study aims to explore whether A. muricata exhibits hepatotoxic properties.

MATERIALS AND METHODS:
A comprehensive literature search was conducted to identify the phytochemicals present in the fruit pulp of A. muricata. The potential toxicophores of these identified phytochemicals were then assessed through in silico analysis. Furthermore, molecular docking studies were performed to evaluate the binding affinity of each phytochemical with various hepatic enzymes.

RESULTS:
Our findings show that approximately half of the identified phytochemicals were predicted to possess hepatotoxic properties, potentially impairing liver function. Phytochemicals identified with toxic substructures include 2-methoxyphenol, 2,4,5-trimethoxybenzoic acid, chromocor, 2-isopropyl-3-phenyl, 4-oxide quinoxaline, 9-octadecen-12-ynoic acid methyl ester, 5-methyl-2 (3H)-furanone, tributyl aconitate, butyl citrate, tributyl acetyl citrate, 4-hydroxy-beta-ionone, and 1,2-diiodoethane. However, only six of these phytochemicals demonstrated high binding affinities with gamma-glutamyl transferase, CYP3A4, and CYP2D6, with most also showing high absorbability.

CONCLUSION:
These results suggest that the potential hepatotoxicity of soursop may be linked to altered drug metabolism and reduced glutathione biosynthesis. Consequently, the consumption of A. muricata should be regulated until further in vitro and in vivo studies provide conclusive evidence to the contrary.
Screening the Subsistence of Bacterial Propagation in Different Units of Tertiary Hospitals in Bangladesh Along with Their Drug Susceptible Pattern
Authors: Shom Pranto , Sultana Raquiba , Rahaman Md. Habibur , Sushree Susmita Banik , Supti Mahima Hossain , Sayem Md. A. R. M. , Acharjee Mrityunjoy 
Published: December 2024

Abstract

BACKGROUND:
Antibiotic resistance is concerning since it has been associated with higher mortality and healthcare expenditures, especially for patients, physicians, and the healthcare system. In order to address the significant issue of antibiotic-resistant patterns of pathogen, the current research aimed to isolate hospital-acquired bacterial stains from the premises of many private and public medical college hospitals in Dhaka, Bangladesh, India.

MATERIALS AND METHODS:
To conduct this study, the samples were collected from different units, for example, intensive care unit, general ward, gynecological ward, emergency ward and outdoor unit, employing swab technique method, and transferred aseptically in the Microbiology Laboratory of Stamford University Bangladesh. The drug-resistant profile of the isolates was estimated through the disk-diffusion method.

RESULTS:
The pattern of resistance of the isolates was clearly evident against seven different antibiotics such as cefexime (5 μg), ciprofloxacin (5 μg), Co-Trimoxazole (25 μg), cefuroxime (30 μg), gentamycin (10 μg), nalidixic acid (30 μg), and Polymyxin B (300 μg). According to our findings, Staphylococcus spp., Escherichia coli, Klebsiella spp., Bacillus anthracis, and Haemophilus influenza showed resistance against all the antibiotics except gentamycin (10 μg).

CONCLUSION:
The study revealed the multidrug resistance in clinically identified pathogens which is very alarming and could be the prime reason for spading the nosocomial infection.
Multiple liver metastases of unknown origin: A case report
Authors: Wang Ying-Jin , Liu Ze-Chuan , Wang Jian , Yang Yin-Mo 
Published: December 2024

BACKGROUND
The liver is the most common site of digestive system tumor metastasis, but not all liver metastases can be traced back to the primary lesions. Although it is unusual, syphilis can impact the liver, manifesting as syphilitic hepatitis with inflammatory nodules, which might be misdiagnosed as metastasis.
CASE SUMMARY
This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three months. No definitive diagnosis of a tumor had been made in the past decades, but signs of multiple liver metastases were recognized after a computed tomography scan without evidence of primary lesions. With positive serological tests for syphilis and a biopsy of the liver nodules, a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis therapy.
CONCLUSION
Clinicians must be aware of the possibility that syphilis can cause hepatic inflammatory masses, especially when liver metastasis is suspected without evidence of primary lesions. A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.
Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population
Authors: Lin Si-Yun , Huang Hou , Yu Jin-Jie , Su Feng , Jiang Tian , Zhang Shao-Yuan , Lv Lu , Long Tao , Pan Hui-Wen , Qi Jun-Qing , Zhou Qiang , Tang Wei-Feng , Ding Guo-Wen , Wang Li-Ming , Tan Li-Jie , Yin Jun 
Published: December 2024

BACKGROUND
Transforming growth factor-β (TGF-β) superfamily plays an important role in tumor progression and metastasis. Activin A receptor type 1C (ACVR1C) is a TGF-β type I receptor that is involved in tumorigenesis through binding to different ligands.
AIM
To evaluate the correlation between single nucleotide polymorphisms (SNPs) of ACVR1C and susceptibility to esophageal squamous cell carcinoma (ESCC) in Chinese Han population.
METHODS
In this hospital-based cohort study, 1043 ESCC patients and 1143 healthy controls were enrolled. Five SNPs (rs4664229, rs4556933, rs77886248, rs77263459, rs6734630) of ACVR1C were assessed by the ligation detection reaction method. Hardy-Weinberg equilibrium test, genetic model analysis, stratified analysis, linkage disequilibrium test, and haplotype analysis were conducted.
RESULTS
Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC, and those with rs77886248 TA mutant were related with higher risk, especially in older male smokers. In the haplotype analysis, ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC, while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.
CONCLUSION
ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC, which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
Hubungan Tingkat Kecukupan Zat Gizi Makro dan Aktivitas Fisik terhadap Status Gizi Atlet Bulutangkis di Kecamatan Kulisusu Kabupaten Buton Utara
Authors: Ayu Putri Inggri Fidayani Dwi , Dhesa Desiderius Bela , Abadi Ellyani , Ananda Siti Hadrayanti 
Published: December 2024

Bulutangkis menjadi satu dari beberapa cabang olahraga Indonesia yang paling digemari dan telah berkembang menjadi cabang olahraga unggulan Indonesia yang bergengsi dimata dunia. Nutrisi dibutuhkan untuk memenuhi kebutuhan tubuh dalam beraktivitas saat berolahraga; jika nutrisi ini tidak cukup untuk memenuhi asupan pada badan kita, yang terjadi adalah keseimbangan energi yang buruk dan jika terjadi pada waktu lama maka akan mengakibatkan status gizi jadinya tidak normal dan akan berpengaruh terhadap kesehatan. Pada penelitian ini bertujuan untuk mengetahui hubungan kecukupan zat gizi makro dan aktivitas fisik terhadap status gizi atlet bulutangkis di Kecamatan Kulisusu Kabupaten Buton Utara. Jenis penelitian yang digunakan adalah observasional dengan desain penelitian cross sectional study. Sampel pada penelitian ini merupakan atlet bulutangkis usia yaiyu 10-25 tahun di Kecamatan Kulisusu Kabupaten Buton Utara dengan menggunakan teknik pengamblan sampel accidental sampling.serta unntuk Pengumpulan data menggunakan timbangan berat badan, microtoise, recall 2x24 jam dan kuesioner IPAQ serta dianalisis menggunakan uji fisher exact. Hasil pada penelitian dapat disimpulkan bahwa ada hubungan antara asupan karbohidrat dan protein terhadap status gizi, sedangkan untuk asupan lemak dan aktivitas fisik tidak terdapat hubungan trhadap status gizi. Bagi atlet bulutangkis, sebaiknya penuhi kebutuhan asupan tubuh guna menjaga status gizi tetap normal dan sehat karena aktivitas fisik yang tinggi.

Absctract
Badminton is one of Indonesia's most popular sports and has developed into a pre-eminent Indonesian sport that is prestigious in the eyes of the world. Nutrition is needed to meet the needs of the body in activities during exercise; if these nutrients are not sufficient to meet the body's needs, a negative energy balance will occur and if this goes on for a long time it will result in abnormal nutritional status and will affect health. This study aims to determine the relationship between adequacy of macronutrients and physical activity on the nutritional status of badminton athletes in Kulisusu District, North Buton Regency. This type of research is an observational study with a cross-sectional study design. The sample in this study were badminton athletes aged 10-25 years in Kulisusu District, North Buton Regency using accidental sampling technique. Data were collected using body weight scales, microtoise, 2 x 24 hour recall and IPAQ questionnaires and analyzed using the Fisher's exact test. The results of this study indicate that there is a relationship between carbohydrate and protein intake on nutritional status, whereas for fat intake and physical activity there is no relationship to nutritional status. For badminton athletes, it is better to fulfill the body's intake needs in order to maintain normal and healthy nutritional status due to high physical activity
Hubungan Penyajian Makanan dengan Sisa Makanan Pasien Rawat Inap di RSUD Kabupaten Wakatobi
Authors: Nurilhida Nurilhida , Demmalewa Jenny Qlifianti , Ananda Siti Hadrayanti 
Published: December 2024

Perhentian terakhir dalam perjalanan kuliner adalah penyajian. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana hubungan praktik penyajian makanan dengan sisa makanan rawat inap di RSUD Wakatobi. Sampel penelitian adalah 86 pasien rawat inap RSUD Wakatobi. Purposive sampling digunakan dalam pendekatan pengambilan sampel ini. Desain penelitian bersifat cross sectional dan bersifat kuantitatif. metode pengumpulan data dengan menggunakan alat, seperti lembar observasi dan angket. Uji Chi square merupakan uji statistik. Berdasarkan temuan penelitian, sebagian besar responden baik laki-laki maupun perempuan yang meninggalkan sisa makanan berusia antara tiga puluh hingga tiga puluh lima tahun. Penelitian terhadap kebiasaan makan responden mengungkapkan mayoritas mengonsumsi makanan yang disajikan di rumah sakit. Pengaruh unsur eksternal seperti kualitas makanan, warna, rasa, tekstur, aroma, dan ketepatan waktu pelayanan terhadap kejadian sisa makanan pada pasien rawat inap. Jumlah rata- rata sisa makanan (>20%) dianggap berada di atas kebutuhan layanan minimal. Temuan sisa makanan (Sisa) yang tidak dimakan pasien rata-rata 60,3% untuk makanan pokok (nasi), 60,3% untuk lauk hewani, 58,8% untuk lauk nabati, 63,2% untuk sayur, dan 60,3% untuk buah. Mutu makanan terdiri dari penampilan makanan dan rasa makanan yang terdiri dari beberapa aspek yaitu warna makanan kategori suka sebanyak 26 responden tidak suka sebanyak 42 responden (p=0,011), aroma makanan kategori suka sebanyak 27 responden, tidak suka sebanyak 41 responden (p=7,30), terkstur makanan kategri suka sebanyak 27 responden, tidak suka sebanyak 41 responden (p=0,027), rasa makanan kategori suka sebanyak 41 responden, tidak suka sebanyak 27 responden (p=0, 00) dan waktu penyajian makanan yang tepat waktu sebanyak 34 responden, tidak tepat waktu 34 responden (p=0,046). Penelitian menyimpulkan bahwa sisa makanan dari pasien rawat inap berkorelasi dengan penyajian, warna, rasa, dan tekstur. Sedangkan sisa makanan dari pasien rawat inap tidak ada hubungannya dengan bau makanan.
The Role of Emotional Attachment in the Impact of Generation Z's Trust in Digital Influencers on Unplanned Purchase Behavior
Authors: Ateş Alper , Sunar Halil , Erdem Bilal 
Published: December 2024

By 2024, the global Internet user base is expected to reach 5.5 billion, with 94% actively engaging on social media platforms. Marketing managers increasingly employ strategies involving key opinion leaders to connect with Generation Z, a demographic known for its digital fluency and reliance on social networks. This study utilizes a qualitative approach to investigate how emotional attachment impacts Generation Z consumers’ trust in social media figures and its effect on impulsive buying behavior. It contributes to the body of knowledge on digital marketing by identifying factors that enhance the effectiveness of social media personalities in reaching and persuading Generation Z audiences.
The findings provide actionable insights for content creators aiming to expand their following and for businesses seeking to strengthen their credibility and drive consumer purchasing decisions through collaboration with digital creators. The results reveal that emotional attachment to online personalities is a crucial driver of trust among Generation Z, significantly affecting their unplanned purchasing habits. Additionally, emotional connection acts as a catalyst, amplifying the impact of trust on spontaneous buying tendencies.
Although trust in social media figures has a notable effect on unplanned purchasing, the relatively weak correlation underscores the need for further exploration of additional factors influencing Generation Z’s decision-making processes.
From Digital Social to Box Office Revenue: Analysis of the Impact and Trends of Electronic Word‑of‑Mouth
Authors: Qiao Weihua 
Published: December 2024

In the digital era, Electronic Word-of-Mouth (eWOM) — the online sharing of opinions and information about movies — has become a crucial factor influencing box office performance. Social media posts, reviews, and ratings shape audience perceptions and impact their choices. This study aims to comprehensively analyze the influence of eWOM on movie box office revenue, identifying key research areas, seminal works, and influential authors in this field, along with highlighting research trends through keyword analysis. The results reveal that the research field is divided into three stages: initial, exploratory, and empirical, with recent emphasis on factors such as the quantity, quality, and credibility of eWOM, significantly affecting consumer behavior. The study also identifies key eWOM research trends, including movie marketing, relevance analysis, and sentiment analysis of reviews. Target audiences include film industry professionals and academic researchers interested in understanding the role of eWOM in enhancing box office performance.
Images of I. V. Stalin and A. Hitler in Historical Memory: Constructing the Past in the Media Space
Authors: Artamonov Denis S. , Sidorov Sergei P. , Tikhonova Sophia V. 
Published: December 2024

The article is devoted to the consideration of the images of I. Stalin and A. Hitler in historical memory. The construction of ideas about the past is based on the possibilities of media, which in the digital age are becoming limitless. With the help of media, images of the past are integrated into the agenda and actualized in the mass consciousness, and personalized figures of history are most in demand. The historical memory of modern society is largely formed on the basis of ideas about the events and heroes of the 20th century, which include the history of totalitarian regimes and the Second World War. The authors put two key figures of the last century with contradictory historical reputations at the center of their research. The article shows the importance of I. Stalin and A. Hitler for historical memory on the basis of available sociological research data. A corpus analysis of the tonality of news reports mentioning these historical figures allowed us to present the proportions of positive and negative use of their names in foreign media publications. Quantitative data made it possible to compare attitudes towards Stalin and Hitler in English-language information resources and explain certain trends in the dynamics of their representation by the nature of the news content. The study of Internet users’ search queries allowed us to supplement the idea of the directions of constructing images of the Soviet leader and the Nazi Fuhrer in historical memory. The data obtained demonstrate the high interest of the world community in ambiguous historical figures. Their images have become part of popular culture, they are used in political struggle and entertainment network discourse, which leaves an imprint on the formation of ideas about them in the media environment. The use of quantitative analysis data to study the images of I. Stalin and A. Hitler makes it possible to determine their place in the historical memory of the modern global community.