bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pushing the Limits of Transmission Concurrency for Low Power Wireless Networks
Authors: Liu Daibo , Cao Zhichao , Hou Mengshu , Rong Huigui , Jiang Hongbo 
Published: September 2020

Concurrent transmission (CT) has been widely adopted to optimize the throughput of various data transmissions in wireless networks, such as bulk data dissemination and high-rate data collection. In CT, besides the possible data frame collision at receivers, we observe that acknowledgment frame (ACK) collision at senders can also significantly diminish concurrency opportunities.
In this article, to avoid the potential ACK collision in CT, we propose ALIGNER which develops a new transmission pattern to coordinate concurrent senders in a distributed manner. The key idea is to align the silent periods of concurrent transmitters. To achieve this goal, we align the end of data frames concurrently transmitted by several senders. Therefore, the potentially arriving ACKs can avoid a collision with ongoing data transmissions because the concurrent senders are in a listening state to wait for receivers’ ACKs for a short and fixed period. ALIGNER can be applied for both deterministic and opportunistic forwarding protocols. It optionally uses a random back-off and slotted ACK mechanism to avoid a potential collision among simultaneously arrived ACKs in opportunistic forwarding. In addition, ALIGNER adopts a tailor-made metrics to analyze the throughput benefit of concurrent transmission for both deterministic and opportunistic data collection protocols. We have implemented ALIGNER in TinyOS and conducted extensive experiments on a real testbed. Experimental results show that ALIGNER can significantly increase the concurrency opportunities in both deterministic (up to 105%) and opportunistic (up to 89.7%) forwarding compared with the state-of-the-art CT methods.
Low Levels of Alcohol Consumption and Risk of Intestinal Metaplasia: A Cohort Study
Authors: Kim Kyungeun , Chang Yoosoo , Ahn Jiin , Yang Hyo-Joon , Ryu Seungho 
Published: September 2020

Abstract

Background:
The impact of alcohol drinking on gastric precancerous lesions remains unclear. We investigated the relationship of alcohol intake with risk of atrophic gastritis (AG) and intestinal metaplasia (IM).

Methods:
This study included 202,675 Korean adults free from AG and IM on their initial endoscopy who were followed with repeated endoscopic examinations. A parametric proportional hazards model was used to estimate the adjusted HR (aHR) with 95% confidence interval (CI) for incident AG and IM based on endoscopic diagnosis.

Results:
During a mean follow-up of 4.7 years, 64,853 incident AG cases and 4,536 IM cases were identified. Alcohol consumption including drinking frequency, quantity, and binge drinking were consistently associated with increased risk of both AG and IM in a dose–response manner. After adjustment for confounders, the multivariable aHRs (95% CIs) for incident IM comparing average alcohol intake of &lt;10, 10–&lt;20, 20–&lt;40, and ≥40 g/day with lifetime abstainers were 1.27 (1.02–1.56), 1.34 (1.07–1.66), 1.50 (1.20–1.86), and 1.54 (1.23–1.93), respectively. Former drinkers were also at a higher risk for AG and IM compared with lifetime abstainers. These associations were consistently observed in never smokers and in time-dependent analyses.

Conclusions:
In a large cohort of Korean individuals, alcohol intake even at low levels was independently associated with increased risk of developing endoscopic AG and IM, supporting a role of alcohol consumption in the pathogenesis of AG and IM, the precursor lesions of stomach cancer.

Impact:
Alcohol consumption from low-level drinking may contribute to gastric carcinogenesis.
Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer
Authors: Burkhart Deborah L. , Morel Katherine L. , Wadosky Kristine M. , Labbé David P. , Galbo Phillip M. , Dalimov Zafardjan , Xu Bo , Loda Massimo , Ellis Leigh 
Published: September 2020

Abstract
Chemoprevention trials for prostate cancer by androgen receptor or androgen synthesis inhibition have proven ineffective. Recently, it has been demonstrated that the histone methlytransferase, EZH2 is deregulated in mouse and human high-grade prostatic intraepithelial neoplasia (HG-PIN). Using preclinical mouse and human models of prostate cancer, we demonstrate that genetic and chemical disruption of EZH2 expression and catalytic activity reversed the HG-PIN phenotype. Furthermore, inhibition of EZH2 function was associated with loss of cellular proliferation and induction of Tp53-dependent senescence. Together, these data provide provocative evidence for EZH2 as an actionable therapeutic target toward prevention of prostate cancer.
The Acceptability and Preference of Vaginal Self-sampling for Human Papillomavirus (HPV) Testing among a Multi-ethnic Asian Female Population
Authors: Khoo Su Pei , Lim Wen Tzien , Rajasuriar Reena , Nasir Nazrila Hairizan , Gravitt Patti , Woo Yin Ling 
Published: September 2020

Abstract

Vaginal self-sampling for human papillomavirus (HPV) testing can potentially increase cervical screening coverage. This study aimed to investigate the acceptability of vaginal self-sampling for HPV testing and factors that might influence a woman's preference for this as a cervical screening method. This was a cross-sectional study that recruited 725 women from the urban and suburban areas of Selangor, Malaysia. All study participants were instructed to self-collect vaginal sample using a dry flocked swab before responding to a detailed questionnaire documenting their experience and preference for self-sampling. Most of the study participants (&gt;80%) perceived vaginal self-sampling as easy, convenient, not embarrassing, comfortable, and were confident in performing the test. This suggests high acceptability toward vaginal self-sampling for HPV testing. Of the 725 women, 83% preferred self-sampling HPV testing over healthcare personnel sampling HPV testing and Pap test. Women with higher household income and full-time employment status were more likely to prefer self-sampling. Those who had not undergone Pap test also expressed preference for self-sampling HPV testing. Convenience and women's confidence in performing a vaginal self-sampling for HPV testing were the independent key factors that influenced the preference for self-sampling method. Vaginal self-sampling for HPV testing is highly acceptable among Malaysian women. It is the preferred choice as a primary cervical screening method and serves as an alternative to healthcare-acquired sample for Pap test.

Prevention Relevance:
Organized cervical cancer screening remains unachievable in many countries. Self-sampling HPV testing is an evidence-based method that can remove barriers to cervical screening. This is particularly important for developing countries in order to achieve the WHO global strategy to accelerate cervical cancer elimination.
Desenvolvimento neuropsicomotor e o brincar de crianças em uma unidade de educação infantil
Authors: Teixeira Natali Machado Pena , Lourenço Priscila Barros , Costa Elson Ferreira , Oliveira Luísa Sousa Monteiro , Cruz Dalízia Amaral 
Published: September 2020

Este estudo teve como objetivo verificar a relação entre as características do brincar e o desenvolvimento neuropsicomotor de crianças de uma Unidade de Educação Infantil (UEI). Trata-se de uma pesquisa com delineamento longitudinal, de caráter descritivoexploratório, observacional e com abordagem quantitativa dos dados. Participaram 23 crianças, de ambos os sexos, com idade entre 3 e 4 anos, matriculadas em uma UEI do município de Belém-PA, em 2017. Para registro das características do brincar das crianças na escola foi utilizado o Protocolo de Observação do Brincar (POB) e para avaliação do desenvolvimento neuropsicomotor usou-se o Teste de Denver II. O estudo revelou que 56,5% das crianças apresentaram o resultado suspeita de atraso no desenvolvimento. As variáveis do brincar que tiveram associação estatisticamente significativa com a suspeita de atraso no DNPM, a partir do Teste U de Mann-Whitney foram: interação em grupo (p=0,04), brincadeira proposta pelo objeto (p=0,03) e não brincadeira-exploração (p=0,02). Considera-se que esta pesquisa possa contribuir para a identificação precoce de desvios no desenvolvimento de crianças no contexto escolar.
Análise qualitativa do efeito da terapia por contensão induzida em crianças com paralisia cerebral
Authors: Rohr Liz Araújo , Santana Camila Araújo , Silva Erika Shirley Moreira da , Alvarez Carolina Daniel de Lima , Maia Gabriela Lopes dos Santos , Tudella Eloisa 
Published: September 2020

This study describes the results of four children with hemiparetic cerebral palsy, age between four and eleven years (6.50± 3.32) who had performed a Constraint-induced Movement Therapy (CIMT) protocol. The purpose was to analyze qualitatively the effects of the CIMT protocol on the use of the affected upper limb. The protocol was performed for three weeks, with restriction of the nonaffected upper limb and functional activities were performed with the transfer of gains during treatment to the real environment. A qualitativeanalysis of the upper limb movement was performed through the Quality of Upper Skills Test (QUEST) scale and the assessment of distal adjustments. Improvements on the QUEST scale score and on the distal adjustments were observed in all four participants after the training protocol. The constraint-induced movement therapy may be an effective intervention aiming to improve the quality of the upper limb movement in children with hemiparetic cerebral palsy.
O brincar de faz de conta como ferramenta na expressão do imaginário de crianças em tratamento quimioterápico hospitalizadas
Authors: Campos Stefanny Maria Santana de , Garcia Luara Engracia , Pfeifer Luzia Iara 
Published: September 2020

Objetivo: Compreender os comportamentos e vivências de crianças submetidas ao tratamento quimioterápico por meio do brincar de faz de conta. Métodos: Estudo de casos múltiplos, abrangendo 5 crianças em uma enfermaria de oncopediatria, para tratamento quimioterápico, tendo como estratégia o brincar de faz de conta. As sessões foram filmadas, com posterior transcrição realizada por duas avaliadoras independentes, garantindo maior fidedignidade dos dados, e separando-os em categorias de análise.Resultados: De acordo com as categorias definidas, pode-se identificar que durante o faz de conta as crianças apresentaram boa exploração e escolha adequada dos materiais; houve presença de distratoresdurante a brincadeira; a imitação não foi um recurso utilizado pelas crianças em suas ações; apesar de trazerem temas domésticos em seu brincar, a hospitalização aparece como tema principal, demonstrandogrande riqueza de detalhes e conhecimento sobre os procedimentos clínicos vivenciados. Conclusão: Apesar das limitações impostas pelo processo quimioterápico, o engajamento das crianças nas brincadeirasde faz de conta se mostrou efetivo e favoreceu a expressão dos sentimentos acerca do processo vivenciado.
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages
Authors: Jia Daile , Bai Peiyuan , Wan Naifu , Liu Jiao , Zhu Qian , He Yuhu , Chen Guilin , Wang Jing , Chen Han , Wang Chen , Lyu Ankang , Lazarus Michael , Su Yunchao , Urade Yoshihiro , Yu Ying , Zhang Jian , Shen Yujun 
Published: September 2020

Rationale:

Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular remodeling, accompanied by varying degrees of perivascular inflammation. Niacin, a commonly used lipid-lowering drug, possesses vasodilating and proresolution effects by promoting the release of prostaglandin D
2
(PGD
2
). However, whether or not niacin confers protection against PAH pathogenesis is still unknown.

Objective:
This study aimed to determine whether or not niacin attenuates the development of PAH and, if so, to elucidate the molecular mechanisms underlying its effects.

Methods and Results:

Vascular endothelial growth factor receptor inhibitor SU5416 and hypoxic exposure were used to induce pulmonary hypertension (PH) in rodents. We found that niacin attenuated the development of this hypoxia/SU5416–induced PH in mice and suppressed progression of monocrotaline-induced and hypoxia/SU5416–induced PH in rats through the reduction of pulmonary artery remodeling. Niacin boosted PGD
2
generation in lung tissue, mainly through H-PGDS (hematopoietic PGD
2
synthases). Deletion of H-PGDS, but not lipocalin-type PGDS, exacerbated the hypoxia/SU5416–induced PH in mice and abolished the protective effects of niacin against PAH. Moreover, H-PGDS was expressed dominantly in infiltrated macrophages in lungs of PH mice and patients with idiopathic PAH. Macrophage-specific deletion of H-PGDS markedly decreased PGD
2
generation in lungs, aggravated hypoxia/SU5416–induced PH in mice, and attenuated the therapeutic effect of niacin on PAH.

Conclusions:

Niacin treatment ameliorates the progression of PAH through the suppression of vascular remodeling by stimulating H-PGDS–derived PGD
2
release from macrophages.
Exome Array Analysis of Early-Onset Ischemic Stroke
Authors: Jaworek Thomas , Ryan Kathleen A. , Gaynor Brady J. , McArdle Patrick F. , Stine Oscar C. , OConnor Timothy D. , Lopez Haley , Aparicio Hugo J. , Gao Yan , Lin Xiaochen , Groves Megan L. , Flaherty Matthew L. , Liu Simin , Yang Qiong , Wilson James , Seshadri Sudha , Kittner Steven J. , Mitchell Braxton D. , Xu Huichun , Cole John W. 
Published: September 2020

Background and Purpose:
The genetic contribution to ischemic stroke may include rare- or low-frequency variants of high-penetrance and large-effect sizes. Analyses focusing on early-onset disease, an extreme-phenotype, and on the exome, the protein-coding portion of genes, may increase the likelihood of identifying such rare functional variants. To evaluate this hypothesis, we implemented a 2-stage discovery and replication design, and then addressed whether the identified variants also associated with older-onset disease.

Methods:
Discovery was performed in UMD-GEOS Study (University of Maryland-Genetics of Early-Onset Stroke), a biracial population-based study of first-ever ischemic stroke cases 15 to 49 years of age (n=723) and nonstroke controls (n=726). All participants had prior GWAS (Genome Wide Association Study) and underwent Illumina exome-chip genotyping. Logistic-regression was performed to test single-variant associations with all-ischemic stroke and TOAST (Trial of ORG 10172 in Acute Stroke Treatment) subtypes in Whites and Blacks. Population level results were combined using meta-analysis. Gene-based aggregation testing and meta-analysis were performed using seqMeta. Covariates included age and gender, and principal-components for population structure. Pathway analyses were performed across all nominally associated genes for each stroke outcome. Replication was attempted through lookups in a previously reported meta-analysis of early-onset stroke and a large-scale stroke genetics study consisting of primarily older-onset cases.

Results:

Gene burden tests identified a significant association with
NAT10
in small-vessel stroke (
P
=3.79×10
−
6
). Pathway analysis of the top 517 genes (
P
<0.05) from the gene-based analysis of small-vessel stroke identified several signaling and metabolism-related pathways related to neurotransmitter, neurodevelopmental notch-signaling, and lipid/glucose metabolism. While no individual SNPs reached chip-wide significance (
P
<2.05×10
−7
), several were near, including an intronic variant in
LEXM
(rs7549251;
P
=4.08×10
−
7
) and an exonic variant in
TRAPPC11
(rs67383011;
P
=5.19×10
−
6
).

Conclusions:
Exome-based analysis in the setting of early-onset stroke is a promising strategy for identifying novel genetic risk variants, loci, and pathways.
Robotic Light Touch Assists Human Balance Control During Maximum Forward Reaching
Authors: Johannsen Leif , Potwar Karna , Saveriano Matteo , Endo Satoshi , Lee Dongheui 
Published: September 2020

Objective We investigated how light interpersonal touch (IPT) provided by a robotic system supports human individuals performing a challenging balance task compared to IPT provided by a human partner. Background IPT augments the control of body balance in contact receivers without a provision of mechanical body weight support. The nature of the processes governing the social haptic interaction, whether they are predominantly reactive or predictive, is uncertain. Method Ten healthy adult individuals performed maximum forward reaching (MFR) without visual feedback while standing upright. We evaluated their control of reaching behavior and of body balance during IPT provided by either another human individual or by a robotic system in two alternative control modes (reactive vs. predictive). Results Reaching amplitude was not altered by any condition but all IPT conditions showed reduced body sway in the MFR end-state. Changes in reaching behavior under robotic IPT conditions, such as lower speed and straighter direction, were linked to reduced body sway. An Index of Performance expressed a potential trade-off between speed and accuracy with lower bitrate in the IPT conditions. Conclusion The robotic IPT system was as supportive as human IPT. Robotic IPT seemed to afford more specific adjustments in the human contact receiver, such as trading reduced speed for increased accuracy, to meet the intrinsic demands and constraints of the robotic system or the demands of the social context when in contact with a human contact provider.
Risk Factors for Recurrence After Arthroscopic Instability Repair—The Importance of Glenoid Bone Loss >15%, Patient Age, and Duration of Symptoms: A Matched Cohort Analysis
Authors: Dekker Travis J. , Peebles Liam A. , Bernhardson Andrew S. , Rosenberg Samuel I. , Murphy Colin P. , Golijanin Petar , Provencher Matthew T. 
Published: September 2020

Background: Glenoid bone loss (GBL) has been implicated as a risk factor for failure of arthroscopic anterior glenohumeral instability repair. Although certain amounts of GBL are associated with higher recurrence rates, there are limited studies on successes versus failures in these cohorts. Purpose: To compare the outcomes of arthroscopic Bankart repair in patients with and without GBL to determine a threshold percentage of GBL that predicts success. Study Design: Cohort study; Level of evidence, 2. Methods: All consecutive patients who underwent arthroscopic Bankart repair for anterior shoulder instability between 2004 and 2013 were prospectively enrolled. Patients with ≤25% GBL were included. Patients with no GBL were grouped and compared with those having 5% to 25% GBL. Outcomes included Single Assessment Numerical Evaluation, Western Ontario Shoulder Index, and American Shoulder and Elbow Surgeons scores, with evidence of recurrent instability. Patients with and without GBL were statistically compared with respect to outcomes and recurrence rates. Results: Of 434 eligible patients, the cases of 405 (45 female, 360 male; mean age, 27.5 years [range, 18-47 years]) were followed for a mean 61 months (range, 48-96 months). There were 189 (46.6%) with no GBL and 216 (53.3%) with GBL; the mean GBL of the latter cohort was 15% (range, 5%-25%). The mean duration of instability symptoms was 7.9 months (range, 1-21 months) and was significantly longer in the GBL group ( P < .05). The mean recurrence rate was 14.8%, which was significantly greater in patients presenting with GBL versus those with none (48/216 [22.2%] vs 12/189 [6.3%]; P < .01). Within the GBL group, GBL ≥15%, duration of symptoms >5 months, and younger age (<20 years) were independent risk factors for failure ( P < .01). Patients with any GBL had >4-times greater odds of recurrence after arthroscopic stabilization (odds ratio, 4.21; 95% CI, 2.16-8.21). Moreover, patients presenting for arthroscopic Bankart repair with GBL ≥15% had nearly 3-times greater odds of recurrent instability. Conclusion: GBL ≥15% in an active patient population portends to increased odds of recurrent instability events and inferior clinical outcomes after arthroscopic Bankart repair. Furthermore, nonmodifiable risk factors, such as age (<20 years) and duration of symptoms before presentation (>5 months), significantly affect risk of recurrence and should be key factors when counseling patients on risk of failure and determining the ideal procedure for the individual patient.
Characterizing Family Physicians Who Refer to Telepsychiatry in Ontario
Authors: Serhal Eva , Iwajomo Tomisin , de Oliveira Claire , Crawford Allison , Kurdyak Paul 
Published: September 2020

Introduction: Telepsychiatry can improve access to psychiatric services for those who otherwise cannot easily access care. Family physicians are gatekeepers to specialized care in Ontario, so it is essential to understand predictors relating to referrals to telepsychiatry to better plan services and increase telepsychiatry adoption. Methods: This study used an annual retrospective cross-sectional study design to compare physicians who referred their patients to telepsychiatry each year from fiscal year (FY) 2008 to FY 2016. A 1-year (FY 2016) comparison of family physicians who referred to telepsychiatry (FPTs) compared to family physicians who did not refer to telepsychiatry (FPNTs) matched (1:2) by region was also conducted. Finally, we used statistical modeling to understand the predictors of referring to telepsychiatry among physicians. Results: Between FY 2008 and FY 2016, the number of patients receiving telepsychiatry increased from 925 visits to 13,825 visits. Thirty-two percent of Ontario primary care physicians referred to telepsychiatry in 2016. Several characteristics were notably different between FPTs and FPNTs: FPTs were more likely to be from a residence with less than 10,000 people, to have more nurse practitioners in the practice, and to be from a family health team than FPNTs. Rostered patients of FPTs were more likely to reside in rural areas, have more clinical complexity, and to utilize more mental health services compared to FPNTs. Conclusions: There has been an increase in the use of telepsychiatry by patients and family physicians over the study period, although there remains opportunity for significant growth. Family physicians who live in rural areas, are part of an FHT, have more NPs, with more rural and complex patients were more likely to refer to telepsychiatry. As recent pro-telemedicine policies support the growth of telepsychiatry, this study will serve as an important baseline.