bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioassessment of Mandakini River with the help of aquatic macroinvertebrates in the vicinity of Kedarnath Wildlife Sanctuary
Authors: Rawat Anjani , Gulati Gunjan , Maithani Rajat , Sathyakumar S. , Uniyal V. P. 
Published: December 2019

AbstractIncreasing advancement in development activities in the Indian Himalayan region in tandem with changing climate is influencing the ecological patterns of rivers. Thus, the present study investigates the effect of various degrees of anthropogenic stresses and possible implication of thermal dynamics of river water on the macroinvertebrate community in the Mandakini River, which flows in the vicinity of Kedarnath Wildlife Sanctuary of Chamoli district, Uttarakhand. The main objective was to study the community structure of macroinvertebrates in the Mandakini River and to calculate the effect of anthropogenic stresses on the macroinvertebrate community, particularly on Ephemeroptera, Plecoptera, and Trichoptera. The study was carried out in 10 spatially located sampling stations, and the frequency of sampling was divided into pre- and post-monsoon season (May and November 2017). Based on the degree of anthropogenic stresses, sampling locations were divided into least (Sonprayag), medium (Ukhimath), and high disturbed (Rudraprayag) sites. A total of 3257 individuals belonging to 7 orders and 21 families were found in both the sampling season. Diptera and Trichoptera were dominant orders in both the seasons, whereas Baetidae (Ephemeroptera), Hydropsychidae, Leptoceridae (Trichoptera) and Chironomidae (Diptera) were dominant families. Shannon diversity index varies from 2.048 to 2.25 in the least disturbed site (Sonprayag), 0.186–2.446 in medium disturbance (Ukhimath), and 1.362–2.271 in the highly disturbed site (Rudraprayag) in both the sampling season. Quantification of the EPT index shows a negative trend with an increase in anthropogenic stress, and it was least in Rudraprayag as compared to the other two sites. Result of one-way ANOVA shows a significant difference in diversity between pre- and post-monsoon season (p < 0.05). Analyzing the research gaps, it is recommended to have long-term ecological monitoring of high altitude and glacier-fed rivers and streams to obtain robust information regarding the dynamics of the riverine ecosystem in Garhwal Himalayas.
The extraordinary autonomy of sports bodies under Swiss law: lessons to be drawn
Authors: Baddeley Margareta 
Published: December 2019

AbstractHigh-profile decisions of the sports governing bodies and subsequent judicial decisions of the Court of Arbitration for Sports (CAS) in Lausanne, the Swiss Federal Tribunal and, sometimes, the European Court of Human Rights frequently draw wide public attention to the fact that in litigations of the sports world, the decisions of the sports governing bodies will generally be upheld on court appeal. This is due to the extraordinary autonomy that sports governing bodies enjoy under Swiss law, deriving on the one hand from the liberal legislations in Switzerland governing associations and arbitration, and on the other hand, from their equally liberal application by the courts, especially in sports-related cases. While the high degree of self-regulation and arbitration in sports allowed the efficient handling of the increasingly complex activities of international sports and of the ever-rising cases of contention among its stakeholders, it is also necessary to point out the flaws of the resulting situation: for the governing bodies of international sports, self-regulation serves primarily the smooth organization of sports, while the specific interests of the subjects of their rules, in particular those of the lower level sports organizations and of athletes, are of secondary importance or may fall completely by the way-side. By contrast, state and international political and judiciary bodies must weigh the interests and rights of all parties involved when regulating relations or deciding in litigation between private parties, so as to ensure that the essential rights of the weaker parties are respected in all situations. This is a heavy responsibility for courts facing the bulk and the power of international sports governing bodies, foremost the Swiss Federal Tribunal, and to a certain extent also the Swiss legislator.
Micromechanical modeling of polycrystalline high manganese austenitic steel subjected to abrasive contact
Authors: Lindroos Matti , Laukkanen Anssi , Andersson Tom 
Published: December 2019

AbstractThis study focuses on microstructural and micromechanical modeling of abrasive sliding contacts of wear-resistant Hadfield steel. 3D finite element representation of the microstructure was employed with a crystal plasticity model including dislocation slip, deformation twinning, and their interactions. The results showed that deformation twinning interacting with dislocations had a key role in the surface hardening of the material, and it was also important for the early hardening process of the sub-surface grains beyond the heavily distorted surface grains. The effects of grain orientation and microstructural features were discussed and analyzed according to the micromechanical model to give a perspective to the anisotropy of the material and the feasibility of using micromechanics in virtual material design.
Three questions about happiness
Authors: HELLIWELL JOHN F. 
Published: December 2019

AbstractThe paper by Frijters, Clark, Krekel and Layard makes a strong historical case for treating happiness as a primary measure of human welfare. They argue that it is now time to revamp the science of policy-making to re-establish this central tradition, building on recent progress in measuring and understanding subjective wellbeing. I agree with them. There are three key questions raised in or by their presentation that need further evidence. I shall try to address these in turn. The questions relate to how to measure happiness, how to measure and deal with inequality and how to take due account of the social context of wellbeing, including the need to achieve consistency between individual and societal happiness.
Finding the VOICE: organic carbon isotope chemostratigraphy of Late Jurassic – Early Cretaceous Arctic Canada
Authors: Galloway Jennifer M. , Vickers Madeleine L. , Price Gregory D. , Poulton Terence , Grasby Stephen E. , Hadlari Thomas , Beauchamp Benoit , Sulphur Kyle 
Published: December 2019

AbstractA new carbon isotope record for two high-latitude sedimentary successions that span the Jurassic–Cretaceous boundary interval in the Sverdrup Basin of Arctic Canada is presented. This study, combined with other published Arctic data, shows a large negative isotopic excursion of organic carbon (δ13Corg) of 4‰ (V-PDB) and to a minimum of −30.7‰ in the probable middle Volgian Stage. This is followed by a return to less negative values ofc. −27‰. A smaller positive excursion in the Valanginian Stage ofc. 2‰, reaching maximum values of −24.6‰, is related to the Weissert Event. The Volgian isotopic trends are consistent with other high-latitude records but do not appear in δ13Ccarbrecords of Tethyan Tithonian strata. In the absence of any obvious definitive cause for the depleted δ13Corganomaly, we suggest several possible contributing factors. The Sverdrup Basin and other Arctic areas may have experienced compositional evolution away from open-marine δ13C values during the Volgian Age due to low global or large-scale regional sea levels, and later become effectively coupled to global oceans by Valanginian time when sea level rose. A geologically sudden increase in volcanism may have caused the large negative δ13Corgvalues seen in the Arctic Volgian records but the lack of precise geochronological age control for the Jurassic–Cretaceous boundary precludes direct comparison with potentially coincident events, such as the Shatsky Rise. This study offers improved correlation constraints and a refined C-isotope curve for the Boreal region throughout latest Jurassic and earliest Cretaceous time.
Ménière's disease clinical subtypes in a population from the USA
Authors: Crossley J , Hussaini A S , Kim H J , Hoa M 
Published: December 2019

AbstractObjectiveTo ascertain the distribution of Ménière's disease phenotype subgroups in a US-based cohort, based on a recently introduced classification scheme utilising a Spanish and Portuguese cohort.MethodsA retrospective, cross-sectional, single-institutional chart review was conducted. The electronic medical records of Ménière's disease patients were identified using International Classification of Diseases codes at a tertiary referral centre and reviewed to extract subgroup-defining features. Patients with definite Ménière's disease as per American Academy of Otolaryngology–Head and Neck Surgery criteria were categorised into one of five subgroups, for unilateral and bilateral Ménière's disease.ResultsEighty-one patients with definite Ménière's disease were identified. Seventy-two cases of unilateral Ménière's disease were observed: 52.8 per cent were type 1, 20.8 per cent were type 2, 4.2 per cent were type 3, 18.1 per cent were type 4, and 4.2 per cent were type 5. This cohort differed significantly in distribution to a comparison Mediterranean cohort (p < 0.01). Nine cases of bilateral Ménière's disease were observed.ConclusionThe distribution of unilateral Ménière's disease subtypes in this US population was different from that observed in a European population.
Potential ecological and socio-economic effects of a novel megaherbivore introduction: the hippopotamus in Colombia
Authors: Subalusky Amanda L. , Anderson Elizabeth P. , Jiménez Germán , Post David M. , Lopez David Echeverri , García-R. Sebastián , Nova León Laura J. , Reátiga Parrish Juan F. , Rojas Ana , Solari Sergio , Jiménez-Segura Luz F. 
Published: December 2019

AbstractIntroduced species can have strong ecological, social and economic effects on their non-native environment. Introductions of megafaunal species are rare and may contribute to rewilding efforts, but they may also have pronounced socio-ecological effects because of their scale of influence. A recent introduction of the hippopotamusHippopotamus amphibiusinto Colombia is a novel introduction of a megaherbivore onto a new continent, and raises questions about the future dynamics of the socio-ecological system into which it has been introduced. Here we synthesize current knowledge about the Colombian hippopotamus population, review the literature on the species to predict potential ecological and socio-economic effects of this introduction, and make recommendations for future study. Hippopotamuses can have high population growth rates (7–11%) and, on the current trajectory, we predict there could be 400–800 individuals in Colombia by 2050. The hippopotamus is an ecosystem engineer that can have profound effects on terrestrial and aquatic environments and could therefore affect the native biodiversity of the Magdalena River basin. Hippopotamuses are also aggressive and may pose a threat to the many inhabitants of the region who rely upon the Magdalena River for their livelihoods, although the species could provide economic benefits through tourism. Further research is needed to quantify the current and future size and distribution of this hippopotamus population and to predict the likely ecological, social and economic effects. This knowledge must be balanced with consideration of social and cultural concerns to develop appropriate management strategies for this novel introduction.
Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol
Authors: Kessel Ellen M. , Frost Allison , Goldstein Brandon L. , Black Sarah R. , Dougherty Lea R. , Carlson Gabrielle A. , Klein Daniel N. 
Published: December 2019

AbstractBackgroundEarly irritability predicts a broad spectrum of psychopathology spanning both internalizing and externalizing disorders, rather than any particular disorder or group of disorders (i.e. multifinality). Very few studies, however, have examined the developmental mechanisms by which it leads to such phenotypically diverse outcomes. We examined whether variation in the diurnal pattern of cortisol moderates developmental pathways between preschool irritability and the subsequent emergence of internalizing and externalizing symptoms 9 years later.MethodWhen children were 3 years old, mothers were interviewed about children's irritability and completed questionnaires about their children's psychopathology. Six years later, children collected saliva samples at wake-up and bedtime on three consecutive days. Diurnal cortisol patterns were modeled as latent difference scores between evening and morning samples. When children were approximately 12 years old, mothers again completed questionnaires about their children's psychopathology.ResultsAmong children with higher levels of irritability at age 3, a steeper diurnal cortisol slope at age 9 predicted greater internalizing symptoms and irritability at age 12, whereas a blunted slope at age 9 predicted greater externalizing symptoms at age 12, adjusting for baseline and concurrent symptoms.ConclusionOur results suggest that variation in stress system functioning can predict and differentiate developmental trajectories of early irritability that are relatively more internalizing v. those in which externalizing symptoms dominate in pre-adolescence.
Nietzsche on the Rise of Strong Political States and Their Cultivation of Higher Individuals
Authors: Townsend Simon 
Published: December 2019

AbstractI argue that Nietzsche offers an account of how strong political states develop and how the highest forms of individuality emerge when the political will of these strong states weakens. Communities develop strength in proportion to the hostility of their environment. In order to flourish in a hostile environment, they must cultivate powerful and ambitious citizens by intensifying their most powerful drives, such as a lust for power. To control these citizens they must ruthlessly suppress individuality and allow these drives to be discharged in ways that do not threaten the community. This is achieved through an inflexible value system. When the political will of the state declines and this moral code weakens, the highest forms of individuality emerge. This account clarifies why Nietzsche tends to praise aristocratic states and brings into focus the obstacles to achieving the highest forms of human flourishing within a democratic state.
Influenza activity prediction using meteorological factors in a warm temperate to subtropical transitional zone, Eastern China
Authors: Liu Wendong , Dai Qigang , Bao Jing , Shen Wenqi , Wu Ying , Shi Yingying , Xu Ke , Hu Jianli , Bao Changjun , Huo Xiang 
Published: December 2019

AbstractInfluenza activity is subject to environmental factors. Accurate forecasting of influenza epidemics would permit timely and effective implementation of public health interventions, but it remains challenging. In this study, we aimed to develop random forest (RF) regression models including meterological factors to predict seasonal influenza activity in Jiangsu provine, China. Coefficient of determination (R2) and mean absolute percentage error (MAPE) were employed to evaluate the models' performance. Three RF models with optimum parameters were constructed to predict influenza like illness (ILI) activity, influenza A and B (Flu-A and Flu-B) positive rates in Jiangsu. The models for Flu-B and ILI presented excellent performance with MAPEs <10%. The predicted values of the Flu-A model also matched the real trend very well, although its MAPE reached to 19.49% in the test set. The lagged dependent variables were vital predictors in each model. Seasonality was more pronounced in the models for ILI and Flu-A. The modification effects of the meteorological factors and their lagged terms on the prediction accuracy differed across the three models, while temperature always played an important role. Notably, atmospheric pressure made a major contribution to ILI and Flu-B forecasting. In brief, RF models performed well in influenza activity prediction. Impacts of meteorological factors on the predictive models for influenza activity are type-specific.
The Ethics of Medical AI and the Physician-Patient Relationship
Authors: DALTON-BROWN SALLY 
Published: December 2019

Abstract:This article considers recent ethical topics relating to medical AI. After a general discussion of recent medical AI innovations, and a more analytic look at related ethical issues such as data privacy, physician dependency on poorly understood AI helpware, bias in data used to create algorithms post-GDPR, and changes to the patient–physician relationship, the article examines the issue of so-called robot doctors. Whereas the so-called democratization of healthcare due to health wearables and increased access to medical information might suggest a positive shift in the patient-physician relationship, the physician’s ‘need to care’ might be irreplaceable, and robot healthcare workers (‘robot carers’) might be seen as contributing to dehumanized healthcare practices.
Accelerated idioventricular rhythm resulting in torsades de pointes and cardiac arrest in a child: successfully cryoablated in left’coronary cusp
Authors: Ergul Yakup , Kafali Hasan C. , Uysal Fahrettin 
Published: December 2019

AbstractKnown as a benign arrhythmia and normally requiring no specific treatment, accelerated idioventricular rhythm can rarely degenerate to a life-threatening arrhythmia. Here, we present a child with left coronary cusp-originating accelerated idioventricular rhythm, degenerating into torsades de pointes and resulting in cardiac arrest, which was ablated with a cryocatheter. An 11-year-old boy, followed due to asymptomatic accelerated idioventricular rhythm before, was referred to our department because he had experienced an aborted cardiac arrest during sleep. He had been resuscitated for 5 minutes. Twenty-four-hour Holter-ECG revealed incessant accelerated idioventricular rhythm, consisting up to 90% of the whole record and two torsades de pointes attacks, triggered by accelerated idioventricular rhythm-induced “R on T” phenomenon, and resulting in syncope and cardiac arrest. Transthoracic echocardiography revealed no structural cardiac defect but mild left ventricular systolic dysfunction with an ejection fraction of 45% and shortening fraction 23%. An electrophysiologic study was conducted, and accelerated idioventricular rhythm focus was mapped to left aortic coronary cusp. A cryocatheter with an 8-mm tip was preferred for successful ablation of the accelerated idioventricular rhythm focus, due to close neighbourhood to coronary ostium. The patient was discharged in 3 days without any premature ventricular contractions or accelerated idioventricular rhythm and with normalised cardiac functions. After 9 months on follow-up, he was still asymptomatic, without any premature ventricular contractions or accelerated idioventricular rhythm and with normal cardiac functions. Although the clinical course of accelerated idioventricular rhythm is known as benign, accelerated idioventricular rhythm can rarely degenerate to a life-threatening arrhythmia. In such cases, electrophysiologic study and catheter ablation are a good option in such cases with accelerated idioventricular rhythm for an ultimate cure.
Subgroup stratification of adult diffuse gliomas and outcomes: an adaptation of the updated WHO classification in a resource-constrained environment
Authors: Naveen T. , Uday Krishna A. S. , Santosh Vani , Arivazhagan A. , Lokesh V. 
Published: December 2019

AbstractIntroduction:The updated World Health Organization 2016 classification of central nervous system tumours recommends the addition of molecular parameters to histological diagnosis. In a resource-constrained setting, molecular testing such as gene sequencing and fluorescence in situ hybridisation is not feasible for all the patients. We assessed the utility of immunohistochemistry (IHC) for isocitrate dehydrogenase (IDH1/R132H) gene and alpha thalassemia/mental retardation syndrome X linked gene (ATRX) to stratify adult diffuse gliomas into subgroups and analysed the outcomes.Materials/Methods:Fifty-eight patients with grades III/IV astrocytic gliomas were tested by IHC for IDH1/R132H and ATRX mutation as per the standard protocol and were later stratified into three subgroups based on IHC. IDH1/R132H positive/ATRX retained gliomas were stratified as group 1 (G1), IDH1/R132H positive/ATRX lost were grouped as G2 and IDH1/R132H negative (with or without ATRX loss) as G3. All patients underwent adjuvant therapy as per the Stupp regimen. Outcomes and survival were analysed by Kaplan–Meier analysis using SPSS 21.v.Results:Median age of the cohort of 58 patients (male: 39, female: 19) was 40 years. Histologically, glioblastoma multiforme (GBM), anaplastic astrocytoma (AA) and anaplastic oligodendroglioma (AOD) were seen in 23:17:18 patients. Forty-eight percent were tested positive for IDH1/R132H, 62% had retained ATRX protein stratifying patients into three subgroups (G1:14, G2:14, G3:30). The G3 group contained both AA and GBM cases. At median follow-up of 18 months, overall survival (OS) of the entire cohort was 76%, higher in G1, compared to G2 and G3 (log-rankp = 0·01). In comparison to various factors such as age, gender, location of the lesion and presenting symptom on survival among various groups, we found that gender of the patient in group I (men vs. women,p = 0·02), laterality of the tumour in group II (right vs. left,p = 0·07) and age of the patient in group III (<45 vs. >45,p = 0·01) demonstrated significant impact on OS.Conclusion:Subgroup stratification of adult diffuse gliomas based on IHC for IDH/R132H and ATRX demonstrates that group 1 was the most favourable prognostic factor. In a resource-constrained environment, IHC alone may guide appropriate management decision for the majority of adult diffuse gliomas, gene sequencing reserved for IDH1/R132H negative GBM in patients less than 45 years of age.
Assessing the Contributions of Comet Impact and Volcanism Toward the Climate Perturbations of the Paleocene‐Eocene Thermal Maximum
Authors: Liu Zeyang , Horton Daniel E. , Tabor Clay , Sageman Bradley B. , Percival Lawrence M.E. , Gill Benjamin C. , Selby David 
Published: December 2019

AbstractThe Paleocene‐Eocene Thermal Maximum is marked by a prominent negative carbon‐isotope excursion, reflecting the injection of thousands of gigatons of isotopically light carbon into the atmosphere. The sources of the isotopically light carbon remain poorly constrained. Utilizing a multiproxy geochemical analysis (osmium isotopes, mercury, sulfur, and platinum group elements) of two Paleocene‐Eocene boundary records, we present evidence that a comet impact and major volcanic activity likely contributed to the environmental perturbations during the Paleocene‐Eocene interval. Additionally, Earth system model simulations indicate that stratospheric sulfate aerosols, commensurate with the impact magnitude, were likely to have caused transient cooling and reduced precipitation.