bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault seal behaviour in Permian Rotliegend reservoir sequences: case studies from the Dutch Southern North Sea
Authors: van Ojik K. , Silvius A. , Kremer Y. , Shipton Z. K. 
Published: October 2019

Abstract
Permian Rotliegend reservoir rocks are generally characterized by high net/gross (N/G) ratios, and faults in such sand-dominated lithologies are typically not considered likely to seal. Nevertheless, many examples of membrane sealing are present in Rotliegend gas fields in the Southern Permian Basin. This manuscript reviews examples of membrane sealing in the Dutch Rotliegend; it presents an extensive dataset of petrophysical properties of Rotliegend fault rocks and analyses two case studies using commonly used workflows.
Fault (membrane) seal studies have been carried out on two Rotliegend fields to test the level of confidence and uncertainty of prediction of ‘across fault pressure differences’ (AFPD) based on existing SGR-based algorithms. From the field studies it is concluded that observable small AFPDs are present and that these are likely pre-production AFPDs due to exploration-time scale trapping and retention of hydrocarbons. Two shale gouge ratio (SGR)-based empirical algorithms have been used here to estimate AFPDs in lower N/G reservoir intervals with the aim of predicting membrane seal behaviour, and these results are compared to field data. It is concluded the selected SGR-based tools predict AFPD for Upper Rotliegend lower N/G reservoir rocks with reasonable results. Nonetheless, the core sample datasets show a much wider range of permeability and capillary entry pressure than predicted by the selected SGR transforms. This highlights the potential to modify existing workflows for application to faults in high N/G lithologies. Data sharing and collaboration between industry and academics is encouraged, so that in the long run workflows can be developed specifically for faults in high N/G lithologies.
Inhibition of the ATR–CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2
Authors: Koppenhafer Stacia L. , Goss Kelli L. , Terry William W. , Gordon David J. 
Published: October 2019

Abstract

Inhibition of ribonucleotide reductase (RNR), the rate-limiting enzyme in the synthesis of deoxyribonucleotides, causes DNA replication stress and activates the ataxia telangiectasia and rad3-related protein (ATR)-checkpoint kinase 1 (CHK1) pathway. Notably, a number of different cancers, including Ewing sarcoma tumors, are sensitive to the combination of RNR and ATR-CHK1 inhibitors. However, multiple, overlapping mechanisms are reported to underlie the toxicity of ATR-CHK1 inhibitors, both as single agents and in combination with RNR inhibitors, toward cancer cells. Here, we identified a feedback loop in Ewing sarcoma cells in which inhibition of the ATR–CHK1 pathway depletes RRM2, the small subunit of RNR, and exacerbates the DNA replication stress and DNA damage caused by RNR inhibitors. Mechanistically, we identified that the inhibition of ATR-CHK1 activates CDK2, which targets RRM2 for degradation via the proteasome. Similarly, activation of CDK2 by inhibition or knockdown of the WEE1 kinase also depletes RRM2 and causes DNA damage and apoptosis. Moreover, we show that the concurrent inhibition of ATR and WEE1 has a synergistic effect in Ewing sarcoma cells. Overall, our results provide novel insight into the response to DNA replication stress, as well as a rationale for targeting the ATR, CHK1, and WEE1 pathways, in Ewing sarcoma tumors.

Implications:
Targeting the ATR, CHK1, and WEE1 kinases in Ewing sarcoma cells activates CDK2 and increases DNA replication stress by promoting the proteasome-mediated degradation of RRM2.
A Universal Law of Estuarine Mixing
Authors: Burchard Hans 
Published: October 2019

AbstractA universal law of estuarine mixing is derived here, combining the approaches of salinity coordinates, Knudsen relations, total exchange flow, mixing definition as salinity variance loss, and the mixing–exchange flow relation. As a result, the long-term average mixing within an estuarine volume bounded by the isohaline of salinity S amounts to M(S) = S2Qr, where Qr is the average river runoff into the estuary. Consequently, the mixing per salinity class is m(S) = ∂SM(S) = 2SQr, which can also be expressed as the product of the isohaline volume and the mixing averaged over the isohaline. The major differences between the new mixing law and the recently developed mixing relation based on the Knudsen relations are threefold: (i) it does not depend on internal dynamics of the estuary determining inflow and outflow salinities (universality), (ii) it is exactly derived from conservation laws (accuracy), and (iii) it calculates mixing per salinity class (locality). The universal mixing law is demonstrated by means of analytical stationary and one-dimensional and two-dimensional numerical test cases. Some possible consequences for the salinity distribution in real estuaries are briefly discussed. Since the mixing per salinity class only depends on the river runoff and the chosen salinity, and not on local processes at the isohaline, low-mixing estuaries must have large isohaline volumes and vice versa.
The presence, characteristics and correlates of pathological social withdrawal in Taiwan: An online survey
Authors: Wu Alison Fang-Wei , Catmur Caroline , Wong Paul WC , Lau Jennifer YF 
Published: October 2019

Objectives: Pathological social withdrawal (PSW) has become a public health concern, especially in Asia. However, few studies have investigated the presence of PSW and its characteristics in Taiwan. In this study, we aimed to discover whether individuals in Taiwan display PSW behaviours, the demographic characteristics and psychiatric history of those meeting criteria for PSW and the associated psychological risks. Methods: An online self-report survey collected participants’ demographic characteristics, social behaviours and their psychiatric history, along with information on adherence to cultural norms and mental health. Results: Among 1,046 valid respondents, 9% reported behaviours consistent with PSW for at least 6 months, commensurate with other online surveys in Asian countries. Around 20% of these also reported current or past psychiatric disorders, although this was lower than previous findings (50%–80%). Participants with PSW reported poorer mental health and lower confidence in social/academic/work skills than unaffected participants. Conclusion: This study identified for the first time the presence of PSW in Taiwan. Except the lower rates of psychiatric comorbidity (which could be explained by sociocultural factors and sampling methods), data were consistent with previous findings. We also extended our understanding of possible psychological risk factors associated with this pathological condition.
Major depression subtypes are differentially associated with migraine subtype, prevalence and severity
Authors: Pisanu Claudia , Lundin Emma , Preisig Martin , Gholam-Rezaee Mehdi , Castelao Enrique , Pistis Giorgio , Merikangas Kathleen R , Glaus Jennifer , Squassina Alessio , Del Zompo Maria , Schiöth Helgi B , Mwinyi Jessica 
Published: October 2019

Objective Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investigating a) the lifetime associations between the atypical, melancholic, combined and unspecified subtype of major depressive disorder and migraine with and without aura and b) the associations between major depressive disorder and its subtypes and the severity of migraine. Methods A total of 446 subjects with migraine (migraine without aura: n = 294; migraine with aura: n = 152) and 2511 controls from the population-based CoLaus/PsyCoLaus study, Switzerland, were included. Associations between major depressive disorder subtypes and migraine characteristics were tested using binary logistic or linear regression. Results Melancholic, combined and unspecified major depressive disorder were associated with increased frequency of migraine with aura, whereas only melancholic major depressive disorder was associated with increased frequency of migraine without aura. Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while combined major depressive disorder was associated with higher migraine frequency independently from migraine subtype. Conclusion This study suggests that melancholic but not atypical major depressive disorder is associated with migraine and migraine subtypes. Future studies exploring pathophysiological mechanisms shared between melancholic depression and migraine are warranted.
Pharmacist-Led Annual Wellness Visits: A Review
Authors: Osae Sharmon P. , Rotelli Alaina 
Published: October 2019

Objective: To summarize findings of pharmacist involvement with Medicare Annual Wellness Visits (AWV), including the number of pharmacist interventions, patient/provider satisfaction, and billing models. Data Sources: A literature search was conducted using PubMed, ScienceDirect College Edition Journals Collection-Health and Life Sciences, Cochrane Library, CINAHL, Medline, and Academic Search Complete, including dates between January 01, 2011, and November 05, 2018. Study Selection: Search was limited to full-text, peer-reviewed articles, published in English which were relevant based on identification of a pharmacist’s role in AWV. Search terms included “Medicare annual wellness visits” and “Pharmacists.” Data Extraction: A data extraction tool was used to collect study authors, year published, study design, description of intervention, objectives, primary outcome measures, model of care, clinic setting, location, results, number of patients, and overall effect. Results: Of the 139 returned citations, 11 met inclusion criteria. Of the practice settings, 7 (72.72%) utilized a collaborative practice agreement for conducting AWV. Six (54.54%) of the studies measured financial outcomes, 3 (27.27%) measured satisfaction of students/patients/physicians, 2 (18.18%) measured clinical outcomes, and finally 4 (36.36%) measured number and types of interventions. Review revealed that 6 (54.54%) articles had more medication-related interventions than nonmedication-related interventions. Studies evaluating finances as it relates to AWVs had various findings including 38% return on investment, higher reimbursement for pharmacist-led visits, and an increase in revenue. Conclusion: In a variety of outpatient health centers, AWV were conducted by pharmacists, had a positive impact on patient care, and had high satisfaction rates between patients and physicians.
The validity of telemedicine-based screening for retinopathy of prematurity in the Premature Eye Rescue Program in Hungary
Authors: Maka Erika , Kovács Gábor , Imre László , Gilbert Clare , Szabó Miklós , Németh János , Nagy Zoltán Zsolt , Somogyvári Zsolt 
Published: October 2019

Purpose To assess the validity of wide-field digital imaging (WFDI) and telemedicine-based screening compared with examination by binocular indirect ophthalmoscopy (BIO) and to present some of the results from the first five years of telemedicine-based screening in the Premature Eye Rescue Program in Hungary. Methods We performed a retrospective analysis in two periods that aimed to assess (a) the validity of retinal digital imaging and (b) routine bedside screening. The validity was assessed in two neonatal intensive care units (NICUs), one in the First Department of Paediatrics and the other in the Second Department of Obstetrics and Gynaecology, Semmelweis University. The telemedicine-based WFDI (WFDI-TM) screening program was introduced in two phases. In the first phase (from 30 November 2009 to 8 August 2010), BIO and WFDI were performed by the same paediatric ophthalmologist (Group A). In the second phase (from 9 August 2010 to 29 March 2011), BIO was performed by the paediatric ophthalmologist, while retinal images were captured by a trained neonatal transport nurse practitioner (Group B). BIO screening was the reference method as a gold standard in both phases. Results During the validity assessment period 634 examinations were performed in 153 preterm infants. Overall, 76 babies were screened in Group A and 80 were screened in Group B. We found lower sensitivity and specificity in cases of any ROP (sensitivity 86%, specificity 99%) compared with those of treatment-requiring retinopathy of prematurity (TR-ROP) (both sensitivity and specificity 100%). In the Premature Eye Rescue Program between 1April 2011 and 31 March 2016, we used WFDI in 3035 infants (4589 procedures). Over this five-year period, 100 (9.6%) infants were treated by laser, and no child who received care in any of the Semmelweis University NICUs became blind from ROP. Conclusions (a) WFDI-TM ROP screening is a useful and efficient approach, although it cannot completely replace BIO; (b) no ROP-related blindness developed among the screened preterm babies; and (c) WFDI-TM ROP screening can be implemented in the logistics of a neonatal emergency and ambulance team infrastructure with neonatal transport nurse practitioners as ‘photographers’.
Pulmonary hypertension after bone marrow transplantation in children
Authors: Levy Marilyne , Moshous Despina , Szezepanski Isabelle , Galmiche Louise , Castelle Martin , Lesage Fabrice , Dupic Laurent , Neven Bénédicte , Fischer Alain , Blanche Stéphane , Bonnet Damien 
Published: October 2019

IntroductionPulmonary hypertension is a rare but important cause of mortality after haematopoietic stem cell transplantation (HSCT) in children. This complication is poorly characterised in the literature. We report here a series of children who developed pulmonary hypertension after HSCT.MethodsBetween January 2008 and December 2015, we retrospectively analysed 366 children who underwent HSCT (age range 0.5–252 months; median 20.3 months). During the post-HSCT course, echocardiography scans motivated by respiratory symptoms identified 31 patients with elevated tricuspid regurgitation velocity (>2.8 m·s−1), confirmed when possible by right heart catheterisation (RHC).Results22 patients had confirmed pulmonary hypertension with mean±sdpulmonary arterial pressure 40.1±10 mmHg (range 28–62 mmHg) and pulmonary vascular resistance 17.3±9.2 Wood Units (range 8–42 Wood Units). Among the 13 responders at reactivity test, only one patient responded to calcium channel blockers. Seven patients (32%) died. 15 pulmonary hypertension patients were alive after a mean±sdfollow-up of 6.5±2.3 years (range 2–10 years). All survivors could be weaned off pulmonary hypertension treatment after a median follow-up of 5 months (range 3–16). The delay between clinical symptoms and initiation of pulmonary hypertension therapy was significantly longer in patients who subsequently died (mean±sd33.5±23 days; median 30 days) than in survivors (mean±sd7±3 days) (p<0.001).ConclusionPulmonary hypertension is a severe complication of HSCT with an underestimated incidence and high mortality. Aggressive and timely up-front combination therapy allowed normalisation of pulmonary pressure and improved survival.
Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling
Authors: Jin Xinxin , Kang Xiaomin , Zhao Liting , Xu Mao , Xie Tianping , Li Huixia , Li Fang , Qian Zhuang , Ma Zhengmin , Zhang Ying , Yang Wei , Zhang Zhuanmin , Gao Xin , Chen Qian , Sun Hongzhi , Wu Shufang 
Published: October 2019

Abstract
A growing body of evidence implies a pivotal role of sirtuin-1 (Sirt1) in chondrocyte function and homeostasis; however, its underlying mechanisms mediating chondrogenesis, which is an essential process for physiological skeletal growth, are still poorly understood. In the current study, we generated TamCartSirt1−/− [Sirt1 conditional knockout (cKO)] mice to explore the role of Sirt1 during postnatal endochondral ossification. Compared with control mice, cKO mice exhibited growth retardation associated with inhibited chondrocyte proliferation and hypertrophy, as well as activated apoptosis. These effects were regulated by hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) signaling, and thereby inhibition of autophagy and induction of endoplasmic reticulum stress in growth plate chondrocytes. IP injection of the mTORC1 inhibitor rapamycin to mice with Sirt1 deletion partially neutralized such inhibitory effects of Sirt1 ablation on longitudinal bone growth, indicating the causative link between SIRT1 and mTORC1 signaling in the growth plate. Mechanistically, SIRT1 interacted with tuberous sclerosis complex 2 (TSC2), a key upstream negative regulator of mTORC1 signaling, and loss of Sirt1 inhibited TSC2 expression, resulting in hyperactivated mTORC1 signaling in chondrocytes. In conclusion, our findings suggest that loss of Sirt1 may trigger mTORC1 signaling in growth plate chondrocytes and contributes to growth retardation, thus indicating that SIRT1 is an important regulator during chondrogenesis and providing new insights into the clinical potential of SIRT1 in bone development.
Guardado en el armario: prejuicios “inexistentes” revelados en autobiografía
Authors: Xavier Carvalho Taís 
Published: October 2019

Gomes, S. (2017). Guardei no armário: a experiência de um jovem homossexual, negro e ex-evangélico na sétima maior cidade do mundo. Porto Alegre, RS: Pragmatha.El libro emGuardei no armário: a experiência de um jovem homossexual, negro e ex-evangélico na sétima maior cidade do mundo/em, autobiografía del autor y diseñador Samuel Gomes, se revela una obra cuya lectura es necesaria no solamente a causa de su autor (negro, homosexual y procedente de los suburbios pobres de São Paulo), sino también por su contenido. La obra aborda las diferentes situaciones preconceptuosas, a veces veladas, vividas por el escritor durante su vida y revela una realidad que muchos prefieren ignorar: la de un Brasil racista y preconceptuoso. Por eso, y por presentar un tema todavía muy actual, el texto de este autor novel es digno de atención y estudio.
Teacher candidates opinions on Arabic textbooks in grades 2-8
Authors: Polat Hüseyin 
Published: October 2019

Textbooks in formal education are a very important tool for the implementation of programs. It also plays a major role in achieving the objectives of the programs. The success of foreign language education in formal education is achieved through books used among other factors. Some individuals who learn Arabic as a foreign language in our country are often looking for problems in learning Arabic in Arabic textbooks in formal education. With this research, determination of these problems and solutions were sought. The research is concerned with the evaluation of the textbooks used in grades 2-8 in the 2018-2019 academic year from the eyes of prospective teachers. 76 prospective teachers who attended 3rd and 4th grades at Gazi University participated in the study. As a result of the research, the idea of developing Arabic textbooks in terms of internal and external structure was dominant. It was suggested that the books should be complementary and that listening, reading, speaking and writing skills would be improved. ​Extended English summary is in the end of Full Text PDF (TURKISH) file. Özet Örgün eğitimdeki ders kitapları, programların uygulanması için çok önemli bir araçtır. Programların hedeflerine ulaşmasında da büyük rol oynamaktadır. Örgün eğitimdeki yabancı dil eğitiminin başarılı olması diğer etkenlerin yanı sıra kullanılan kitaplar sayesinde olmaktadır. Ülkemizde Arapçayı yabancı dil olarak öğrenen bazı bireyler de Arapçayı öğrenmedeki sorunları çoğunlukla örgün öğretimdeki Arapça ders kitaplarında aramaktadırlar. Bu araştırmayla söz konusu sorunların tespiti ve çözüm yolları aranmıştır. Araştırma 2018-2019 eğitim öğretim yılındaki 2-8 sınıflarda kullanılan ders kitaplarını öğretmen adaylarının gözünden değerlendirilmesi ile ilgilidir. Araştırmaya söz konusu eğitim öğretim yılında Gazi Üniversitesi’ndeki 3. ve 4. sınıflarda öğrenim görmek olan 76 öğretmen adayı katılmıştır. Araştırma sonucunda Arapça ders kitaplarının iç ve dış yapı bakımından geliştirilmesi görüşü hâkim olmuştur. Kitapların birbirlerini tamamlar nitelikte olması, dinleme, okuma, konuşma ve yazma becerilerinin geliştirilmesi önerilmiştir.
Study of the behavior of the new insecticide cyantraniliprole in large lysimeters of the Moscow State University
Authors: Kolupaeva Victoria N. , Kokoreva Ann А. , Belik Alexandra A. , Pletenev Pavel A. 
Published: October 2019

Abstract
The behaviour of cyantraniliprole was studied in a lysimetric experiment. The experiment was carried out at the lysimeters of the Soil Research Station of Moscow State University from June 2015 to December 2018. The soil of lysimeter is soddy-podzolic silt loam. The insecticide was applied at the recommended and tenfold rates in 2015 and 2016. The maximum depth of migration of cyantraniliprole in the soil profile was 35 cm in October 2015 and 40 cm in October 2016. Cyantraniliprole was found in the leachate of lysimeter water 2 weeks after its first application in 2015 and continued until the end of 2018, that is, 2 years after the last treatment. Cyantraniliprole was found in most of the water samples analyzed. The maximum concentrations of cyantraniliprole in the leachate were 12.5 and 2.6 μg L−1 in lysimeters with tenfold and recommended doses, with mean values of - 1.7 and 0.6 μg L−1, respectively.
From shipwreck to constellation: Rethinking Meillassoux on Mallarmé from a semiotic perspective
Authors: Hopkins John Arnold Falcon 
Published: October 2019

Abstract
This essay assesses Quentin Meillassoux’s numerological approach to Mallarmé’s problematic but formally innovative poem “Un Coup de dés,” using a semiotic methodology to reveal the deficiencies of that approach from the viewpoint of literary theory. Section 1 describes my expanded version of Michael Riffaterre’s semiotic theory of the structure of modern poetry. Poems are generated by two underlying propositions, each of which governs the structure of a set of symbolic images on the textual surface. These “matricial” propositions are linked by a syntagmatic relation. The primary text functions as subject-sign of the Peircean semiotic triad; its object-sign is an intertextual model. The interpretant of these two textual signs is assembled by the reader and has a sociolectic counterpart – or context – which has similar lexical content but contrasting internal structure. This contrast may produce a change in the preconceptions of the reader. Section 2 examines Meillassoux’s approach to Mallarmé’s poem, which is preoccupied with a “number” supposedly encrypted in the text. This is not convincingly related to the propositional structure of the poem. In Section 3, the text is interpreted using a semiotics-based methodology. The poem is generated by two matrices: one concerning the “Master” versus the storm, and the second concerning the power of Chance. The relation linking the matrices is clarified. This analysis is compared with that of Meillassoux throughout. Section 4 resumes the differences between Meillassoux’s concentration on the “number” and the “siren,” and my analysis which centres on the relation between the Master (symbolising traditional poets and their preferred metre) and the Constellation (symbolising the wide range of new future poetic metres and formats). Meillassoux’s approach turns out to be unconvincing.