bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of second primary tumors and outcomes in medulloblastoma by treatment modality: A Surveillance, Epidemiology, and End Results analysis
Authors: Nantavithya Chonnipa , Paulino Arnold C. , Liao Kaiping , McGovern Susan L. , Grosshans David R. , McAleer Mary F. , Woodhouse Kristina D. , Khatua Soumen , Chintagumpala Murali M. , Majd Nazanin K. , Yeboa Debra N. 
Published: May 2020

AbstractBackgroundAs treatment modalities for medulloblastoma have developed and overall survival (OS) has improved, there are relatively limited data on the impact of long‐term effects such as risk of second primary tumors (SPT). To address the knowledge gap, we analyzed factors associated with the risk of SPT and OS by treatment modality for medulloblastoma.MethodsWe queried the Surveillance, Epidemiology, and End Results (SEER)‐18 database for patients diagnosed with medulloblastoma in 1973‐2014. Patients were then grouped by age, gender, race, geographic region, histology, adjuvant treatment (no radiation [RT] and no chemotherapy [CT], RT and CT, RT alone, or CT alone), era of diagnosis (1973‐1994 or 1995‐2014), and survival time. Cumulative incidence, factors associated with SPT and OS were analyzed.ResultsOf 2271 patients, 146 developed SPT, of which 42 were benign. The incidence of SPT was 3.1% and 4.9% at 10 and 15 years, respectively. The incidence of SPT was 3.1% with RT + CT versus 3.7% with RT alone at 10 years. The most common site for an SPT was the central nervous system. Female gender (P = 0.01) and longer OS of ≥21 years (P < 0.01) were associated with higher risk of SPT. RT + CT led to better OS than RT only (66.1% and 61.4% vs 55.6% and 49.7% at 10 and 15 years) (P < 0.01).ConclusionsMedulloblastoma patients have a relatively low risk of SPT at 10 years with treatment. Use of RT + CT led to better OS with no statistical difference in SPT compared with the RT alone.
Estimating thermal conductivity of frozen soils from air‐filled porosity
Authors: Tian Zhengchao , Ren Tusheng , Heitman Joshua L. , Horton Robert 
Published: May 2020

AbstractSoil thermal conductivity (λ) is an important thermal property for environmental, agricultural, and engineering heat transfer applications. Existing λ models for frozen soils are complicated to use because they require estimates of both liquid water content and ice content. This study introduces a new approach to estimate λ of partially frozen soils from air‐filled porosity (na), which can be determined by using an oven‐drying method. A λ and na relationship was established based on measurements for 28 partially frozen soils. A strong exponential relationship between λ and na was found (with R2 of 0.82). Independent tests on 10 partially frozen soils showed that the exponential λ–na model produced reliable λ estimates with a RMSE of 0.319 W m−1 K−1, which was smaller than those of two widely used λ models for partially frozen soils. The λ–na model is easier to use than existing models, because it requires fewer parameters. Note that the λ‐na model ignores the effect of temperature on λ of frozen soils and is most applicable to soil at temperatures of at least −4 °C.
Method development of statistical modeling for the description of welding fume emissions in gas metal arc welding using transient process characteristics
Authors: Reisgen Uwe , Sharma Rahul , Christ Martin , Mann Samuel 
Published: May 2020

AbstractIn the past, most approaches to reduce welding fume emissions were primarily based on welding consumables, whereas in the context of the present work, a new concept with direct reference to the welding process technology is pursued. Many other measures to improve occupational health and safety, such as use of extended personal protective equipment (e.g., forced air ventilated helmets) and extraction systems, relate to the reduction of immissions of welding fumes already emitted. In comparison, the selection of optimized parameter settings in terms of gas metal arc welding (GMAW) provides a process-related possibility to reduce welding fume emissions without the need for additional equipment. In order to illustrate and quantify the functional interdependencies between process parameterization and the resulting fume emission generation, a model relationship is developed which is primarily based on empirical investigations. Via post-process analysis, certain features are extracted from the transient measurement data and correlated with the process-specific emission rates. With the help of the model, individual parameters can be iteratively set on the basis of representative process features. Besides parameter optimization with regard to emission-reduced processes, a forecast of the expected fume emission rate can be derived based on the selected settings. The methodology described and examined is applicable to different process spaces of GMAW or even other fume-emitting welding processes.
Investigation of electropolishing characteristics of tungsten in eco-friendly sodium hydroxide aqueous solution
Authors: Han Wei , Fang Feng-Zhou 
Published: May 2020

AbstractIn this study, an eco-friendly electrolyte for electropolishing tungsten and the minimum material removal depth on the electropolished tungsten surface are investigated using an electrochemical etching method. Using a concentrated acid electrolyte, the polarization curve and current density transient are observed. For a NaOH electrolyte, the effects of interelectrode gap and electrolyte concentration on electropolishing are investigated. The differences in electropolishing characteristics are compared among different electrolyte types. Microholes are etched on the electropolished tungsten surface to determine the minimum material removal depth on the tungsten surface. Experimental results indicate the color effect due to a change in the thickness of the oxide film on the tungsten surface after electropolishing with a concentrated acid electrolyte. The surface roughness decreases with the interelectrode gap width owing to the increased current density when using the NaOH electrolyte. However, the electropolishing effect is less prominent with a significantly smaller gap because the generated bubbles are unable to escape from the narrow working gap in time. A material removal depth of less than 10 nm is achieved on the tungsten surface in an area of diameter 300 µm, using the electrochemical etching method.
A Diverse Specialty: What Students Teach Us About Neurology and “Neurophobia”
Authors: Moore Fraser G. A. 
Published: May 2020

ABSTRACT:Objective:To explore what elective students learn about the specialty of Neurology.Methods:A prospective qualitative study using pre- and post-elective written questionnaires.Results:Analysis concentrated on three main themes: What did students learn about the specialty of Neurology? What would they change about their experience? Did their opinions change? Major findings were (i) pre- and post-elective the most frequent response for “what is the best thing about Neurology?” was the “process of localization” and (ii) post-elective students were less likely to cite the challenge or problem-solving aspect of Neurology as the best thing while more emphasized the importance of the physical exam and the variety of cases. (iii) Students were most surprised by the scope of neurological practice. (iv) They would diversify the setting of their elective to include less time spent in the emergency room and more time in clinic. (v) The perception of Neurology as a specialty in which patients have a poor prognosis was the opinion that changed the most.Conclusions:Showcasing the diversity of cases and careers in Neurology may be a useful strategy to increase interest in the specialty and reduce neurophobia. Lectures or small groups early in medical school should concentrate on clear examples of common neurological conditions and emphasize the role of general neurologists and subspecialists involved in patient care. Whenever possible students should rotate through different clinics and not concentrate exclusively on emergency room and in-patient cases.
Serial Hurricanes The 2017 Hurricane Public Health Responses: Case Studies Illustrating the Role of Centers for Disease Control and Prevention’s Public Health Emergency Preparedness Program
Authors: Martinez DeAndrea , Landon Kelcie A. , McDermott Wesley , Roth Joseph , Schnall Amy Helene , Talbert Todd P. , Mainzer Hugh M. 
Published: May 2020

ABSTRACT
The Centers for Disease Control and Prevention (CDC), Division of State and Local Readiness (DSLR), Public Health Emergency Preparedness(PHEP) program funds 62 recipients to strengthen capability standards to prepare for and respond to public health emergencies. Recipients use these PHEP resources in addition to CDC’s administrative and scientific guidance to support preparedness and response program planning and requirements. It is expected that public health agencies develop and maintain comprehensive emergency preparedness and response plans in preparation for disasters such as hurricanes. The 2017 historic hurricane season highlighted how emergency planning and collaborative operational execution is important for public health agencies to effectively prepare for and respond to both the immediate and long-term population health consequences of these disasters. In 2017, the southeastern United States (US) and US Caribbean territories experienced 3 Category 4 or higher Atlantic hurricanes (Harvey, Irma, and Maria) within a 5-week period. This paper highlights selected case studies that illustrate the contributions and impact of jurisdictional emergency management planning and operational capacity supported by capability standards during the 2017 hurricane season. Although the magnitude of the 2017 hurricanes required public health officials to seek additional assistance, the following case studies describe the use of public health preparedness systems and recovery resources supported by the PHEP program.
The Three Graces of Leadership: Untangling the Relative Importance and the Mediating Mechanisms of Three Leadership Styles in Russia
Authors: Koveshnikov Alexei , Ehrnrooth Mats , Wechtler Heidi 
Published: May 2020

ABSTRACTDrawing on the job-demand resource theory, the article examines the relative importance and the complementarity of three widely practiced leadership styles – transformational, paternalistic, and authoritarian. It investigates how the three styles relate to followers’ work engagement amongst employees in Russian domestic organizations. It also theorizes and tests the mediating effects of three psychological mechanisms, namely self-efficacy, self-esteem, and job control, on the examined relationships. The findings show that all three leadership styles relate to followers’ work engagement positively. The relationship of transformational leadership is dominant and mediated by all three psychological mechanisms. The remaining two styles also make their unique contributions to followers’ work engagement. Whereas authoritarian leadership influences followers by enhancing their self-efficacy and self-esteem, paternalistic leadership operates more extrinsically by increasing followers’ job control. Surprisingly, our analyses found that the role of control variables such as gender, age, and hierarchical position were insignificant in predicting how the three leadership styles influence employee work engagement. The study is among the first to shed light on the relative importance of the three focal leadership styles, their differential influences and interrelations, and the different mechanisms through which they relate to followers’ work engagement.
THE VALLEY OF JUIGALPA, MAYALES RIVER SUBBASIN MICROREGION (CHONTALES, NICARAGUA) DATE LIST II
Authors: Donner Natalia R , Geurds Alexander 
Published: May 2020

ABSTRACTThe material evidence of human presence in the Chontales region of central Nicaragua spans from 1420 ± 30 BP, or cal AD 554–670 (±2σ) through to the present, as was recently established (Donner and Geurds 2018). This cultural chronology, divided into three main periods, contrasts with the one previously proposed by (Gorin 1990), who defined six different phases from 500 BC through AD 1600. Here, we report on 11 new radiocarbon (14C) assays, introducing an update to the cultural sequence, consisting of two considerable changes, while also providing further overall strengthening. First, the earliest traces of human groups are now placed at 1645 ± 25 BP, or cal AD 263–536 (±2σ); second, five different periods are established for the research area. A recalibration of Gorin’s dates identified their consistency with the results reported here, supporting the new cultural chronology of central Nicaragua. Additionally, this study achieved the complete temporal characterization of Aguas Buenas, the largest pre-colonial archaeological site in Nicaragua.
Molecular characterisation of methicillin-resistant Staphylococcus aureus from chronically colonised cystic fibrosis paediatric patients in Brazil
Authors: Rodrigues D. C. S. , Lima D. F. , Cohen R. W. F. , Marques E. A. , Leão R. S. 
Published: May 2020

Abstract
Persistent methicillin-resistant Staphylococcus aureus (MRSA) infection in cystic fibrosis (CF) patients has been associated with a more rapid decline in lung function, increased hospitalisation and mortality. The aim of this study was to evaluate the clonal relationships among 116 MRSA isolates from 12 chronically colonised CF pediatric patients over a 6-year period in a Rio de Janeiro CF specialist centre. Isolates were characterised by antimicrobial resistance, SCCmec type, presence of Panton-Valentine Leukocidin (PVL) genes and grouped according to DNA macrorestriction profile by pulsed-field gel electrophoresis (PFGE) and spa gene type. High resistance rates were detected for erythromycin (78%) and ciprofloxacin (50%) and SCCmec IV was the most common type (72.4%). Only 8.6% of isolates were PVL positive. High genetic diversity was evident by PFGE (39 pulsotypes) and of nine that were identified spa types, t002 (53.1%) and t539 (14.8%) were the most prevalent. We conclude that the observed homogeneity of spa types within patients over the study period demonstrates the persistence of such strain lineages throughout the course of chronic lung infection.
The Influence of Personality and Drinking Motives on College Student	Binge Drinking in the US and Portugal
Authors: Martin Jessica L. , Ferreira Joaquim Armando , Haase Richard F. , Martens Matthew P. , Coelho Mariana , Martins Jorge , Jome LaRae M. , Santos Eduardo R. 
Published: May 2020

Abstract. The present study examined whether personality traits and drinking motives interact to predict binge drinking and alcohol-related problems in a cross-cultural sample of college students. Participants were undergraduate drinkers ( N = 904; 66% female) from universities in Portugal ( N = 391) and the US ( N = 513). Participants completed measures assessing neuroticism, extraversion, conscientiousness, drinking motives, frequency of binge drinking, and the number of alcohol-related problems. A significant Country × Neuroticism × Conformity interaction was explained by differences between US and Portuguese samples. The effect of this interaction on alcohol- related problems was mediated by binge drinking. Findings suggest similarities and differences across cultures in the manner in which personality and drinking motives are associated with alcohol outcomes. Across cultures, neuroticism, extraversion, conscientiousness, and drinking motives are key factors to consider in the assessment, prevention, and treatment of alcohol use among college students.
Projected Impacts of Climate Change on Drought Patterns Over East Africa
Authors: Haile Gebremedhin Gebremeskel , Tang Qiuhong , Hosseini‐Moghari Seyed‐Mohammad , Liu Xingcai , Gebremicael T. G. , Leng Guoyong , Kebede Asfaw , Xu Ximeng , Yun Xiaobo 
Published: May 2020

AbstractInvestigation of the pressing impacts of climate change on drought is vital for sustainable societal and ecosystem functioning. The magnitude of how much the drought will change and the way how droughts would affect society and the environment are inadequately addressed over East Africa. This study aimed at assessing future drought changes using an ensemble of five Global Climate Models (GCMs) in the Coupled Model Intercomparison Project (CMIP5) over East Africa. To this end, drought characteristics were investigated under the Representative Concentration Pathways (RCPs) 2.6, 4.5, and 8.5 in the near term (the 2020s; 2011–2040), midcentury (2050s; 2041–2070), and end of century (2080s; 2071–2,100). The changes of the Standardized Precipitation Index (SPI) and Standardized Precipitation‐Evapotranspiration Index (SPEI) were first compared, and the SPEI was used for measuring future droughts as it showed stronger changes due to its inclusion of temperature effects. Drought area in East Africa is likely to increase at the end of the 21st century by 16%, 36%, and 54% under RCP 2.6, 4.5, and 8.5, respectively, with the areas affected by extreme drought increasing more rapidly than severe and moderate droughts. Spatially, drought event, duration, frequency and intensity would increase in Sudan, Tanzania, Somalia, and South Sudan, but generally decrease in Kenya, Uganda, and Ethiopian highlands. Results also confirm that drought changes over East Africa follow the “dry gets drier and wet gets wetter” paradigm. The findings provide important guidance for improving identification of causes, minimizing the impacts and enhancing the resilience to droughts in East Africa.
Anomalous Propagation of Radio Waves from Distant ILS Localizers Due to Ionospheric Sporadic‐E
Authors: Sakai J. , Saito S. , Hosokawa K. , Tomizawa I. 
Published: May 2020

AbstractThe ionospheric sporadic‐E (Es) layer occasionally causes anomalous propagation (AP) of VHF radio waves to distant locations. This effect, EsAP, may cause interference to VHF radio operation above 100 MHz. Recent study showed that VHF air navigation signals from distant stations are frequently observed when Es occurs. The observed frequencies includes channels of VHF omnidirectional radio range (VOR) and instrument landing system localizer (ILS LOC). The study showed that EsAP signals can be very strong and frequently exceeded the allowable interference limit of navigation receivers. In this paper, we focus on EsAP on ILS LOC channels using the data obtained in the previous study. A series of extremely strong signals was observed on an ILS LOC frequency at Kure, Japan, on 15 May 2014 when an ionosphere sounder observed high‐density Es. The source of the signal was identified as an ILS LOC‐type direction aid (LDA) at Hualien, Taiwan. During the same period, several EsAP signals were observed on other ILS LOC channels, but their strengths were less significant. Analysis showed the causes of the strong signal from Hualien LDA: (1) the center of the narrow radio beam passed through the region very close to the receiver site; (2) the elevation angle of the propagation path was very close to that of the actual beam center. Statistics showed that there were several outstanding EsAP events of which source was Hualien LDA. This study suggests that if similar conditions exist, radio interference to ILS LOC receiver can happen on any ILS LOC channels.
Evaluation of the activity of a chemo-ablative, thermoresponsive hydrogel in a murine xenograft model of lung cancer
Authors: Rossi Seóna M. , Ryan Benedict K. , Kelly Helena M. 
Published: May 2020

Abstract
Background
Minimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response to temperature, has been proposed as a potential treatment modality for solid tumours. The aim of this study was to assess the inherent cytotoxicity of a poloxamer-based thermoresponsive hydrogel in a murine xenograft model of lung cancer.

Methods
In vitro viability assessment was carried out in a lung cancer (A549) and non-cancerous (Balb/c 3T3 clone A31) cell line. Following intratumoural administration of saline or the thermoresponsive hydrogel to an A549 xenograft model in female Athymic Nude-Foxn1nu mice (n = 6/group), localisation was confirmed using IVIS imaging. Tumour volume was assessed using callipers measurements over 14 days. Blood serum was analysed for liver and kidney damage and ex vivo tissue samples were histologically assessed.

Results
The thermoresponsive hydrogel demonstrated a dose-dependent cancer cell-specific toxicity in vitro and was retained in situ for at least 14 days in the xenograft model. Tumour volume increase was statistically significantly lower than saline treated control at day 14 (n = 6, p = 0.0001), with no associated damage of hepatic or renal tissue observed.

Conclusions
Presented is a poloxamer-based thermoresponsive hydrogel, suitable for intratumoural administration and retention, which has demonstrated preliminary evidence of local tumour control, with minimal off-site toxicity.
Association between serum copper levels and prevalence of hyperuricemia: a cross-sectional study
Authors: Jiang Ting , Xie Dongxing , Wu Jing , He Hongyi , Wang Haochen , Wang Ning , Zhu Zhenglei , Wang Yilun , Yang Tuo 
Published: May 2020

AbstractHyperuricemia has been recognized as a worldwide public health concern. This study was conducted to examine the association between serum copper (Cu) concentration and the prevalence of hyperuricemia in a middle-aged and elderly population. Serum Cu concentration was measured by Roche modular P800 using the PAESA method. Serum uric acid (UA) concentration was detected by a Beckman Coulter AU 5800. Presence of hyperuricemia was defined as serum UA ≥ 416 μmol/L for men and ≥360 μmol/L for women. The association between serum Cu concentration and the prevalence of hyperuricemia was evaluated by logistic regression. The prevalence of hyperuricemia was 17.6% (n = 6,212) in the present study. Relative to the lowest quintile, the age- and sex-adjusted odds ratios for hyperuricemia were 1.38 (95% CI: 1.12 to 1.70), 1.34 (95% CI: 1.07 to 1.66), and 1.53 (95% CI: 1.23 to 1.91) in the third, fourth, and fifth serum Cu concentration quintiles (P for trend < 0.001). Similar results were found both in men and women subgroups. None of the findings were materially altered after adjustment for additional potential confounders. In conclusion, in this population-based cross-sectional study, serum Cu concentration was positively associated with the prevalence of hyperuricemia.
Time-resolved 3D imaging of two-phase fluid flow inside a steel fuel injector using synchrotron X-ray tomography
Authors: Tekawade Aniket , Sforzo Brandon A. , Matusik Katarzyna E. , Fezzaa Kamel , Kastengren Alan L. , Powell Christopher F. 
Published: May 2020

AbstractThe multiphase flow inside a diesel injection nozzle is imaged using synchrotron X-rays from the Advanced Photon Source at Argonne National Laboratory. Through acquisitions performed at several viewing angles and subsequent tomographic reconstruction, in-situ 3D visualization is achieved for the first time inside a steel injector at engine-like operating conditions. The morphology of the internal flow reveals strong flow separation and vapor-filled cavities (cavitation), the degree of which correlates with the nozzle’s asymmetric inlet corner profile. Micron-scale surface features, which are artifacts of manufacturing, are shown to influence the morphology of the resulting liquid-gas interface. The data obtained at 0.1 ms time resolution exposes transient flow features and the flow development timescales are shown to be correlated with in-situ imaging of the fuel injector’s hydraulically-actuated valve (needle). As more than 98.5% of the X-ray photon flux is attenuated within the steel injector body itself, we are posed with a unique challenge for imaging the flow within. Time-resolved imaging under these low-light conditions is achieved by exploiting both the refractive and absorptive properties of X-ray photons. The data-processing strategy converted these images with a signal-to-noise ratio of ~ 10 into a meaningful dataset for understanding internal flow and cavitation in a nozzle of diameter 200 μm enclosed within 1–2 millimeters of steel.