bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide analyses reveal antibiotic resistance genes and mechanisms in pathogenic Pseudomonas bacteria
Authors: Benson Otarigho 
Published: August 2020

Background: The global emergence and re-emergence of antibiotic resistance among the Pseudomonas pathogens causes great problems to patients undergoing chemotherapy. However, there is limited comparative information on the antibiotic resistance genes (ARGs) and mechanisms across the Pseudomonas pathogenic groups. Methods: The complete genomes of five Pseudomonas pathogen groups, P. aeruginosa, P. fluorescens, P. putida, P. stutzeri and P. syringae, were analyzed for ARGs. Results: A significant number of ARGs were identified in the P. aeruginosa genome compared to the other Pseudomonas pathogens. The opportunistic pathogens P. stutzeri and P. putida were shown to be the closest to P. aeruginosa with an average nucleotide identity (%) of 80.30 and 79.52. The pathogen genome with the least hit was P. stutzeri. The four major antibiotic resistance mechanisms that include the efflux, inactivation, target alteration and efflux::target alteration were reported. Conclusion: The findings of this brief report could be useful in understanding the chemotherapeutics against antibiotic resistance strains of Pseudomonas pathogens
Refinement of the critical genomic region for congenital hyperinsulinism in the Chromosome 9p deletion syndrome
Authors: Banerjee Indraneel , Senniappan Senthil , Laver Thomas W. , Caswell Richard , Zenker Martin , Mohnike Klaus , Cheetham Tim , Wakeling Matthew N. , Ismail Dunia , Lennerz Belinda , Splitt Miranda , Berberoğlu Merih , Empting Susann , Wabitsch Martin , Pötzsch Simone , Shah Pratik , Siklar Zeynep , Verge Charles F. , Weedon Michael N. , Ellard Sian , Hussain Khalid , Flanagan Sarah E. 
Published: August 2020

Background: Large contiguous gene deletions at the distal end of the short arm of chromosome 9 result in the complex multi-organ condition chromosome 9p deletion syndrome. A range of clinical features can result from these deletions with the most common being facial dysmorphisms and neurological impairment. Congenital hyperinsulinism is a rarely reported feature of the syndrome with the genetic mechanism for the dysregulated insulin secretion being unknown. Methods: We studied the clinical and genetic characteristics of 12 individuals with chromosome 9p deletions who had a history of neonatal hypoglycaemia. Using off-target reads generated from targeted next-generation sequencing of the genes known to cause hyperinsulinaemic hypoglycaemia (n=9), or microarray analysis (n=3), we mapped the minimal shared deleted region on chromosome 9 in this cohort. Targeted sequencing was performed in three patients to search for a recessive mutation unmasked by the deletion. Results: In 10/12 patients with hypoglycaemia, hyperinsulinism was confirmed biochemically. A range of extra-pancreatic features were also reported in these patients consistent with the diagnosis of the Chromosome 9p deletion syndrome. The minimal deleted region was mapped to 7.2 Mb, encompassing 38 protein-coding genes. In silico analysis of these genes highlighted SMARCA2 and RFX3 as potential candidates for the hypoglycaemia. Targeted sequencing performed on three of the patients did not identify a second disease-causing variant within the minimal deleted region. Conclusions: This study identifies 9p deletions as an important cause of hyperinsulinaemic hypoglycaemia and increases the number of cases reported with 9p deletions and hypoglycaemia to 15 making this a more common feature of the syndrome than previously appreciated. Whilst the precise genetic mechanism of the dysregulated insulin secretion could not be determined in these patients, mapping the deletion breakpoints highlighted potential candidate genes for hypoglycaemia within the deleted region.
Las configuraciones de la convivencia y sus imaginarios: estudio en tres barrios de Armenia (Quindío)
Authors: Mejìa Escobar Bibiana Magaly , Giraldo Lucero , Martìnez Salazar Betty 
Published: August 2020

Se presentan los resultados de la investigación “Cómo estamos conviviendo en la Colombia del siglo XXI”, que tuvo como objetivo general “Comprender, desde la perspectiva de los actores en Armenia, Quindío, las configuraciones de la convivencia y sus imaginarios”. Se estudiaron tres experiencias comunitarias, de iniciativa ciudadana, en barrios que concentran conflictos sociales pero que, también, han encontrado diferentes estrategias para superar su vulnerabilidad y mejorar la calidad de vida.La convivencia se caracterizó con base en tres subcategorías: normatividad, usos y costumbres y pertenencia. El estudio de los imaginarios se abordó desde la propuesta de Pintos (2006), quien sugiere la aplicación del código relevancia/opacidad.Se encontró que, por su participación en las experiencias estudiadas, muchos individuos pudieron resignificar su papel social porque consolidaron nuevos imaginarios. Sin embargo, la convivencia no la orienta el cumplimiento efectivo de normas constitucionales y el respeto por los derechos humanos, sino que se alcanza, incluso, por encima y a pesar de ellas. Normas implícitas como los pactos de silencio y la no denuncia de formas de delincuencia, rigen la vida de estas comunidades. Esas normas, a su vez, determinan los usos y costumbres, así como la pertenencia de los habitantes a la comunidad.
Innovations in the Science and Practice of Decision Analysis: The Role ofManagement Science
Authors: Dyer James S. , Smith James E. 
Published: August 2020

In this paper, we reflect on research in decision analysis that has appeared in Management Science and its impact on decision analysis practice and applications. We consider professional applications of decision analysis in business and government settings as well as everyday conversational applications.This paper was accepted by David Simchi-Levi, Special Section of Management Science: 65th Anniversary.
Improving guideline-mandated care of patients with implantable cardiac defibrillators
Authors: Garner Daniel , Blackburn Matthew , Wright David J , Rao Archana 
Published: August 2020

Background/AimsImplantable cardiac defibrillators reduce the risk of sudden cardiac death in selected patients. The value of an implantable cardiac defibrillator declines as the patient's disease progresses. Guidelines suggest that the appropriateness of maintaining implantable cardiac defibrillator therapy be regularly reviewed as part of monitoring of the patient's disease trajectory. It is recommended that implantable cardiac defibrillators are deactivated as patients approach the end of life. Patients with a better understanding of their current state of health and the role that the implantable cardiac defibrillator plays within it are more likely to make informed decisions about the timing of deactivation.Methods:A quality improvement project was undertaken on appropriate deactivation of implantable cardiac defibrillators within a large tertiary cardiac centre. This was driven by audit data showing inadequate patient communication and documentation around deactivation. Drivers for change included the introduction of electronic data records, clinical review of comorbid patients approaching elective battery change and an ongoing forum for patient and carer education. Measured outcomes included the number of deactivations performed, evidence of patient discussion and consent, and timing of deactivation of the implantable cardiac defibrillator.ResultsThere were increased numbers of timely device deactivations undertaken following the interventions with improved documented evidence of patient discussion and consent. The educational forum was received favourably.ConclusionsFocused multidisciplinary interventions can impact favourably on appropriate implantable cardiac defibrillator deactivation and improve patient engagement.
Orthopaedic manifestations of glutaric acidemia Type 1
Authors: Imerci Ahmet , Strauss Kevin A. , Oleas-Santillan Geovanny F. , Miller Freeman 
Published: August 2020

Purpose Glutaric acidemia type 1 (GA1), a rare hereditary metabolic disease caused by biallelic mutations of GCDH, can result in acute or insidious striatal degeneration within the first few years of life. We reviewed the orthopaedic sequelae and management of 114 neurologically injured patients with a confirmed molecular diagnosis of GA1. Methods We performed a retrospective chart review spanning 28 years identifying 114 GA1 patients, most from the Old Order Amish population of Lancaster County, Pennsylvania, who were homozygous for a pathogenic founder variant of GCDH (c.1262C>T). We collected demographics, medical comorbidities, muscle tone patterns, Gross Motor Function Classification System level, gastrostomy tube status, seizure history, inpatient events, orthopaedic diagnoses and operative characteristics. Results Over an average follow-up of 4.7 ± 3.4 years, 24 (21%) of 114 patients had musculoskeletal problems requiring orthopaedic consultation. Scoliosis (n = 14), hip dislocation (n = 8/15 hips), hip subluxation (n = 2/three hips), and windswept hip deformity (n = 2) in the spine and hip joint were most common. In total, 35 orthopaedic surgeries were performed in 17 (71%) patients. The most common primary operations were one-stage procedures with proximal femoral varus derotation osteotomy and/or pelvic osteotomy (n = 8/14 hips) for subluxation or dislocation. In all, 11 patients had posterior spinal fusion for severe scoliosis. With the recommended metabolic management, there were no disease-specific complications in this cohort. Conclusions Children with GA1 who have static striatal lesions are at risk for musculoskeletal complications, especially scoliosis and hip dislocation, and appropriate operative management requires consultation with a metabolic specialist with specific considerations for fluid management and nutrition. Level of Evidence IV
“It's Not Just About a Paycheck”: Perspectives on Employment Preparation of Students With Intellectual Disability in Federally Funded Higher Education Programs
Authors: Domin Daria , Taylor Allison B. , Haines Kelly A. , Papay Clare K. , Grigal Meg 
Published: August 2020

Abstract
Students with intellectual disability (ID) are increasingly attending postsecondary education institutions and acquiring work experiences while completing their studies. One of the main motivations for students with ID to seek higher education is to broaden and increase their chance for finding fulfilling, paid employment in their communities. Findings from a qualitative study on staff perspectives regarding career development and employment supports and services provided to students attending Transition and Postsecondary Education Programs for Students With Intellectual Disability (TPSID) model demonstration programs in the United States are presented. Results reflect consensus across program staff regarding the goals and expectations for employment of TPSID students. Programs vary considerably in their institutional context, their partnership with other entities, and the structure of employment services, as well as the emphasis placed on paid versus unpaid employment. Some of the key strategies shared by staff regarding successful student employment practices involved outreach and engagement, visibility on campus, improving access to career services, and cultivating partnerships. As higher education continues to expand its offerings to students with ID, postsecondary education programs need to continue to emphasize and honor the importance of paid employment, and continue to seek the best methods to achieve this outcome for students with ID.
Dynamic pose estimation of uncooperative space targets based on monocular vision
Authors: Zhang Zhen , Bin Wu , Kang Jiehu , He Rongfang , Gao Guofang 
Published: August 2020

A novel algorithm of dynamic pose estimation for monocular visual sensor is proposed in this paper. The sensor is principally composed of two 1D turntables, one collimated laser, and one industrial camera. In particular, the proposed algorithm is suitable for the cases of uncooperative targets. By analyzing the motion of a laser beam based on quaternion, the functional detection algorithm is derived from the position information of multiple scanning points. Furthermore, the depth recovery based on a nonparametric model is a key step in the pose calculation, which is unnecessary to make use of the calibration parameters of an industrial camera. It is, however, effective to avoid the influence of camera distortion and calibration error. After establishing a test platform, simulation and experiments for pose estimation are carried out. The experimental results show that the maximum error is 0.98° at a range of 500 mm, which proves that the proposed algorithm is accurate and effective.
Fabrication and characterization of deformed microdisk cavities in silicon dioxide with high Q-factor
Authors: Behrens Arne , Bosch Martí , Fesser Patrick , Hentschel Martina , Sinzinger Stefan 
Published: August 2020

We demonstrate the excitation and characterization of whispering gallery modes in a deformed optical microcavity. To fabricate deformed microdisk microresonators we established a fabrication process relying on dry plasma etching tools for many degrees of freedom and a shape-accurate morphology. This approach allowed us to fabricate resonators of different sizes with a controlled sidewall angle and underetching in large quantities with reproducible properties such as a surface roughness

R
Q

≤
2

n
m

. The excitation and characterization of these modes were achieved by using a state-of-the-art tapered fiber coupling setup with a narrow linewidth tunable laser source. The conducted measurements in shortegg resonators showed at least two modes within a spectral range of about 237 pm. The highest

Q

-factors measured were in the range of

10
5

. Wave optical eigenmode and frequency domain simulations were conducted that could partially reproduce the observed behavior and therefore allow us to compare the experimental results.
Influence of Ho3+ doping on the structural and optical characteristics of ZnO–ZrO2 nanocomposites synthesized by the solution combustion method
Authors: Musembi M. K. , Dejene F. B. , Ahemen I. , Tshabalala K. G. 
Published: August 2020

The

Z
n
O

−

Z
r
O

2

nanocomposites were prepared using varying concentrations of

H
o

3
+

ions through the solution combustion method. Zirconium butoxide and zinc nitrate were used as the precursor solutions with citric acid as a fuel. The synthesis was done at a low temperature of 80°C and then the samples calcined at 600°C for 2 h, before characterization. Rietveld refinement revealed that the nanocomposite consisted of wurtzite zinc oxide, mixed with cubic and tetragonal zirconia phases. Scanning electron microscopy images show dispersed small polygonal crystals within a spongy matrix for lower

H
o

3
+

concentrations, while samples with higher dopant ratios featured larger crystals mixed with rods. The UV spectra had absorption edges from 400 nm with a dopant-dependent energy band gap ranging between 2.78 and 3.04 eV. The nanocomposites exhibited an initial violet emission that varied through blue into the green region, depending on the

H
o

3
+

doping concentration. Dipole–dipole interaction was found to be responsible for the luminescence quenching within the nanocomposite material.
Nonlinearity-aware optoelectronic terahertz discrete multitone signal transmission with a zero-bias diode
Authors: Zhang Lu , Qiao Mengyao , Wang Shiwei , Lu Zijie , Zhang Le , Pang Xiaodan , Zhang Xianmin , Yu Xianbin 
Published: August 2020

The terahertz band has been recognized as a promising candidate to
support future rate-greedy applications such as 6G communications.
Optoelectronic terahertz communications are beneficial for the
realization of high-speed transmission. In this Letter, we propose and
experimentally demonstrate an optoelectronic terahertz transmission
system with intensity modulation and direct detection, where a
discrete multitone (DMT) waveform with high-order quadrature amplitude
modulation (QAM) is used. A zero-bias diode (ZBD) is used in the
system as a simple, cost-effective direct detection terahertz
receiver. A nonlinearity-aware digital signal reception routine is
proposed to mitigate the nonlinear impairments induced by
subcarrier-to-subcarrier beating interference from the ZBD. In this
experiment, up to a 60 Gbit/s line rate 16QAM-DMT signal is
successfully transmitted over a 3 m wireless link in the 310 GHz band,
and the mean signal-to-noise ratio is improved by 3 dB with
nonlinearity-aware signal processing routine. The advantageous
features of such a scheme make it a promising solution for terahertz
wireless communications.
The Children’s Music Studio: A Reggio-inspired Approach, Wendell Hanna (2016)
Authors: Olesko Beatrice B. 
Published: August 2020

Review of: The Children’s Music Studio: A Reggio-inspired Approach, Wendell Hanna (2016)
New York: Oxford University Press, 211 pp.,
ISBN 978-0-19938-479-2, p/bk, $35.00
Cuerpos significantes. Nuevas travesías dialécticas
Authors: Citro Silvia 
Published: August 2020

Este artículo traza una breve genealogía de mis investigaciones socioantropológicas sobre la corporalidad en Argentina, partiendo del entrecruzamiento entre ciertas experiencias intersubjetivas que involucraron intensamente la corporalidad desde lo sensorial y emotivo, las performances artísticas y las etnografías realizadas desde mediados de los años noventa. A partir de esta travesía inicial, que vincula experiencias personales y producciónartística e intelectual, en un contexto geopolítico e histórico determinado, discuto tres problemáticas teóricometodológicas claves en el campo actual de los estudios sobre el cuerpo en América Latina, por cuanto constatamos que también otros colegas de nuestros países las comparten. En primer lugar, sobre los modos en que nuestras corporalidades y, agregaría, nuestras producciones intelectuales sobre el cuerpo son el resultado de un complejo entramado de materialidades biológicas, tecnologías, procesos psicológicos,intersubjetivos, históricos y político-culturales que entrelazan sensaciones, movimientos,afectividades, imágenes, representaciones y discursos. Por ello, creemos que el desafío ante tal complejidad es evitar caer en un reduccionismo del cuerpo que lo someta a la mirada unilateral de una sola disciplina, y tratar de avanzar, en cambio, hacia una progresiva interdisciplinariedad.
Construcción de cuerpos: Fortaleza y armonía en los ideales de cuerpo-sonidomovimiento en las poblaciones afrochocoanas
Authors: María Arango Ana 
Published: August 2020

Esta ponencia es una reflexión sobre uno de los principales conceptos de lainvestigación Velo qué bonito: saberes y prácticas sonoro-corporales en la primera infancia de las poblaciones afrochocoanas: la “fortaleza armónica”.Tras tres años de investigación en cinco municipios del Chocó, uno de sus principales hallazgos fue comprender que los cuidados, imaginarios y discursos alrededor de la relación entre cuerpo, sonido y movimiento reposan en labúsqueda de una fortaleza que, más que física, es espiritual, y de una armonía que se sustenta en la compenetración con el entorno, los seres supranaturales y los lazos familiares.La fortaleza armónica, como ideal que buscan las madres y abuelas choconas en sus bebés, y que más adelante refuerzan los demás miembros de la comunidaden diferentes prácticas sonoro-corporales, muchas veces choca con las políticas y discursos hegemónicos del Estado y que propenden por la consolidación de tipos concretos de subjetividad insertos en la modernidad y la idea de nación.
Bokavia Sebagai Alternatif Media Pembelajaran Pada Olahraga Petanque
Authors: Irawan Fajar Awang , Pangesti Oktavia Pratiwi Diah Ayu 
Published: August 2020

Siswa tingkat sekolah dasar mengalami kesulitan dalam bermain petanque karena bola besi terasa berat saat dimainkan. Tujuan penelitian ini untuk memberikan alternative media permainan melalui modifikasi bola petanque yang lebih murah, ringan, praktis, dan menarik tetapi tetap standar. Penelitian ini menggunakan 10 orang dalam uji coba kecil dan 20 orang dalam uji coba besar dengan rentang usia 8 sampai 10 tahun. Hasil dari penelitian ini pada uji coba skala kecil diperoleh 84% spesifikasi produk pada kategori baik dan 90% relevansi produk juga pada kriteria baik. Untuk uji coba skala besar diperoleh 88% spesifikasi pada kategori baik, sedangkan relevansi produk 92% pada kategori baik pula. Hasil lain pada komentar ahli ditemukan 94.15% untuk kualitas produk Bokavia pada kategori sangat baik dan 96.65% untuk spesifikasi produk juga pada kategori sangat baik. Kesimpulan yang didapat bahwa Bokavia ini layak digunakan untuk bermain petanque dan juga sebagai alternative pilihan dalam pembelajaran.Elementary student felt difficult when playing petanque because of the weight. The aim of this study was to give media alternative using petanque ball modification that more cheap, light, and interesting as petanque standard. This study using 10 participants in small-scale and 20 participants in large-scale with the mean age 8 to 10 years old. Result of this study found that 84% product specifications in small-scale was good and 90% product relevance was also in good category. Large-scale data found 88% product specification in 88% and 92% relevance product was good in category. Results from the expertise found that 94.15% for product quality was very good and 96.65% product specification was also very good. The conclusion stated that Bokavia suitable for was petanque and also as an alternative choice for learning.
Correlation between Knowledge and Attitudes to the Behavior of Personal Hygiene Food Handlers in Nutrient Department
Authors: Hardiah Muayanah , Nabawiyah Hafidhotun , Pibriyanti Kartika 
Published: August 2020

Personal hygiene food handlers of processing food at the hospital nutrition department is very important to control the quality of patient food, to improve patient condition. This is because the presence of good hygiene behavior can reduce the risk of contamination in food. Personal hygiene behavior can be influenced by knowledge and attitude. Some factors to determine the prevalence of congenital diseases in food are the lack of knowledge of food handlers and the inattention to apply hygiene when processing food. The purpose of this study was to determine the correlation between knowledge and attitudes towards personal hygiene behavior food handlers in nutrition department of UNS Hospital Surakarta.
This type of research was quantitative observation with cross sectional research design. The total population was all food processing workers in Nutrition Department of the UNS Hospital of Surakarta with a total of 22 people. Knowledge and attitude data were obtained by using questionnaire wether behavior data was collected by using a checklist form. Data was analysed using Chi Square test.
The results showing the dominant gender of the study is female at 59,1%, then the highest age group is adult at 68,2%, the highest level of education was SMA /SMK 81,8%, the length working time was more than 2 years at 54,5% and the income range is 1.000.000-2.000.000. The level of good food handlers knowledge is 81,8%, good food handlers attitude is 72,7% and good food handlers behavior is 59,1%. Based on statistical tests the results showed that there was no correlation between knowledge and personal hygiene behavior of food handlers p = 1,000 and there was no correlation between attitudes and personal hygiene behavior of food handlers p = 0,178.