bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paine and socioeconomic rights
Authors: Philp Mark 
Published: October 2019

Abstract
This article focuses on Thomas Paine’s Agrarian Justice (1796–7). It argues that it represents a major development in his thinking linking social and economic rights to liberty and seeing positive and negative rights as closely connected. It locates the impetus for these changes in doctrine to his working out of the implications of the principle of generational sovereignty in relation to his developing case for universal manhood suffrage, against the background of discussions of the Directory Constitution of 1795. This account emphasizes the developing character of Paine’s thought and its increasing subtlety as he ties social and economic rights into an account of the pacific character of commercial society, thereby combining economic liberalism with a significant dimension of egalitarianism.
Evaluating Cross-resistance Between Vip and Cry Toxins of Bacillus thuringiensis
Authors: Tabashnik Bruce E , Carrière Yves 
Published: October 2019

Abstract
Crops genetically engineered to produce insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) have revolutionized control of some major pests. Some recently introduced Bt crops make Vip3Aa, a vegetative insecticidal protein (Vip), which reportedly does not share binding sites or structural homology with the crystalline (Cry) proteins of Bt used widely in transgenic crops for more than two decades. Field-evolved resistance to Bt crops with practical consequences for pest control includes 21 cases that collectively reduce the efficacy of nine Cry proteins, but such practical resistance has not been reported yet for any Vip. Here, we review previously published data to evaluate cross-resistance between Vip and Cry toxins. We analyzed 31 cases based on 48 observations, with each case based on one to five observations assessing cross-resistance from pairwise comparisons between 21 resistant strains and 13 related susceptible strains of eight species of lepidopteran pests. Confirming results from previous analyses of smaller data sets, we found weak, statistically significant cross-resistance between Vip3 and Cry1 toxins, with a mean of 1.5-fold cross-resistance in 21 cases (range: 0.30–4.6-fold). Conversely, we did not detect significant positive cross-resistance between Vip3 toxins and Cry2Ab. Distinguishing between weak, significant cross-resistance, and no cross-resistance may be useful for better understanding mechanisms of resistance and effectively managing pest resistance to Bt crops.
Knockdown of Methoprene-Tolerant Arrests Ovarian Development in the Sogatella furcifera (Hemiptera: Delphacidae)
Authors: Hu Kui , Tian Ping , Yang Lu , Qiu Lin , He Hualiang , Ding Wenbing , Li Zhongcai , Li Youzhi 
Published: October 2019

AbstractJuvenile hormone (JH) is responsible for repressing larval metamorphosis and inducing vitellogenesis and egg production in insects. Methoprene-tolerant (Met) is known to be an intracellular receptor and transducer of JH. We examined the role of Met in ovarian development in the rice pest Sogatella furcifera (Horváth). We first cloned and sequenced S. furcifera Met (SfMet). The SfMet protein belongs to the basic helix–loop–helix/Per-Arnt-Sim (bHLH-PAS) family with a bHLH domain and two PAS domains (PAS-A and PAS-B). SfMet was expressed in all developmental stages and tissues but was most highly expressed in the ovaries of adult females. Furthermore, RNA interference (RNAi) mediated silencing of SfMet substantially reduced the expression of SfVg, decreased yolk protein deposition and blocked oocyte maturation and ovarian development. These results demonstrate that SfMet plays a key role in female reproduction in S. furcifera and suggest that targeting this gene could be an effective way of controlling this pest.
Evolutionary Analyses of Base-Pairing Interactions in DNA and RNA Secondary Structures
Authors: Golden Michael , Murrell Benjamin , Martin Darren , Pybus Oliver G , Hein Jotun 
Published: October 2019

AbstractPairs of nucleotides within functional nucleic acid secondary structures often display evidence of coevolution that is consistent with the maintenance of base-pairing. Here, we introduce a sequence evolution model, MESSI (Modeling the Evolution of Secondary Structure Interactions), that infers coevolution associated with base-paired sites in DNA or RNA sequence alignments. MESSI can estimate coevolution while accounting for an unknown secondary structure. MESSI can also use graphics processing unit parallelism to increase computational speed. We used MESSI to infer coevolution associated with GC, AU (AT in DNA), GU (GT in DNA) pairs in noncoding RNA alignments, and in single-stranded RNA and DNA virus alignments. Estimates of GU pair coevolution were found to be higher at base-paired sites in single-stranded RNA viruses and noncoding RNAs than estimates of GT pair coevolution in single-stranded DNA viruses. A potential biophysical explanation is that GT pairs do not stabilize DNA secondary structures to the same extent that GU pairs do in RNA. Additionally, MESSI estimates the degrees of coevolution at individual base-paired sites in an alignment. These estimates were computed for a SHAPE-MaP-determined HIV-1 NL4-3 RNA secondary structure. We found that estimates of coevolution were more strongly correlated with experimentally determined SHAPE-MaP pairing scores than three nonevolutionary measures of base-pairing covariation. To assist researchers in prioritizing substructures with potential functionality, MESSI automatically ranks substructures by degrees of coevolution at base-paired sites within them. Such a ranking was created for an HIV-1 subtype B alignment, revealing an excess of top-ranking substructures that have been previously identified as having structure-related functional importance, among several uncharacterized top-ranking substructures.
Clinical Laboratory Validation and Implementation of Quantitative, Real-Time PCR-based Monitoring of NPM1 Type A Mutation
Authors: Racchumi Joelle , Tam Wayne , Kluk Michael J 
Published: October 2019

ABSTRACTNPM1 is frequently mutated in acute myeloid leukemia (AML) and the mutations consist of a variety of small insertions; the most common NPM1 mutation (ie, Type A) accounts for approximately 80% of all NPM1 mutations. NPM1 mutations have been reported to have prognostic significance in AML and, more recently, monitoring mutant NPM1 levels during and after therapy has been described to predict relapse and survival. Despite the published relevance of this molecular biomarker, routine residual disease monitoring for mutant NPM1 levels has not been widely adopted in many academic clinical laboratories. In this manuscript, we present the validation and implementation of a quantitative, real-time PCR-based method for the monitoring of NPM1 Type A mutant transcripts, for use in routine practice in a clinical laboratory. We have found that this assay format is sensitive and reproducible. We describe the rigorous validation procedure and share observations that will help other clinical laboratories that may wish to implement this type of testing. We show comparison of the results from this assay to other assays and a representative case is provided which highlights the utility of the findings from this assay. Taken together, in the context of molecular testing for residual disease in AML, which is an area of practice that continues to expand, we have found that this method and protocol will serve as an appropriate option for monitoring NPM1 Type A mutation levels in clinical practice.
Proteolysis and neurogenesis modulated by LNR domain proteins explosion support male differentiation in the crustacean Oithona nana
Authors: Sugier Kevin , Laso-Jadart Romuald , Kerbache Soheib , Kafer Jos , Arif Majda , Bertrand Laurie , Labadie Karine , Martins Nathalie , Orvain Celine , Petit Emmanuelle , Poulain Julie , Wincker Patrick , Jamet Jean-Louis , Alberti Adriana , Madoui Mohammed-Amin 
Published: October 2019

AbstractCopepods are the most numerous animals and play an essential role in the marine trophic web and biogeochemical cycles. The genus Oithona is described as having the highest numerical density, as the most cosmopolite copepod and iteroparous. The Oithona male paradox obliges it to alternate feeding (immobile) and mating (mobile) phases. As the molecular basis of this trade-off is unknown, we investigated this sexual dimorphism at the molecular level by integrating genomic, transcriptomic and protein-protein interaction analyses.While a ZW sex-determination system was predicted in O. nana, a fifteen-year time-series in the Toulon Little Bay showed a biased sex ratio toward females (male / female ratio < 0.15±0.11) highlighting a higher mortality in male. Here, the transcriptomic analysis of the five different developmental stages showed enrichment of Lin12-Notch Repeat (LNR) domains-containing proteins coding genes (LDPGs) in male transcripts. The male also showed enrichment in transcripts involved in proteolysis, nervous system development, synapse assembly and functioning and also amino acid conversion to glutamate. Moreover, several male down-regulated genes were involved in the increase of food uptake and digestion. The formation of LDP complexes was detected by yeast two-hybrid, with interactions involving proteases, extracellular matrix proteins and neurogenesis related proteins.Together, these results suggest that the O. nana male hypermotility is sustained by LDP-modulated proteolysis allowing the releases and conversions of amino acid into the excitatory neurotransmitter glutamate. This process could permit new axons and dendrites formation suggesting a sexual nervous system dimorphism. This could support the hypothesis of a sacrificial behaviour in males at the metabolic level.
Accounting for demography in the assessment of wild animal welfare
Authors: Hecht Luke B.B. 
Published: October 2019

AbstractWelfare is experienced by individual animals, but the quantity and average quality of welfare an individual is likely to experience in their lifetime is bounded by population demography; namely, age-specific survivorship and the ecological forces that shape it. In many species, a minority of the individuals who are born survive to adulthood, meaning that the lives of those we observe in nature are often unrepresentative of the typical individual born into their population. Since only living animals are capable of experiencing welfare, lifespan is effectively an upper bound on the amount of affectively positive or negative experience an animal can accrue. Life history strategies that increase the probability of a long life are therefore more permissive of good welfare; but even holding life expectancy constant, specific patterns of age-specific mortality may enable a larger proportion of individuals to live through periods characterized by above-average welfare. I formalize this association between demography and welfare through the concept of welfare expectancy, which is applied to published demographic models for >80 species to illustrate the diversity of age-specific mortality patterns and entertain hypotheses about the relationship between demography and welfare.
The First Reconstruction of Intercellular Interaction Network in Mus musculus Immune System
Authors: Azadian Somayeh , Zahiri Javad , Arab Seyed Shahriar , sajedi Reza Hassan 
Published: October 2019

AbstractIntercellular interactions play an important role in regulating communications of cells with each other. So far, many studies have been done with both experimental and computational approaches in this field. Therefore, in order to investigate and analyze the intercellular interactions, use of network reconstruction has attracted the attention of many researchers recently. The intercellular interaction network was reconstructed using receptor and ligand interaction dataset and gene expression data of the first phase of the immunological genome project. In the reconstructed network, there are 9271 communications between 162 cells which were created through 460 receptor-ligand interactions. The results indicate that cells of hematopoietic lineages use fewer communication pathways for interacting with each other and the most network communications belong to non-hematopoietic stromal cells and macrophages. The results indicated the importance of the communication of stromal cells with immune cells and also high specificity of genes expression in these cells. The stromal cells have the most autocrine communication, and interactions between the wnt5a with the Ror1/2 and Fzd5a among the stromal lineage cells are abundant.
Integrating the effects of price fairness and Islamic altruism with the TPB model
Authors: M. Sayuti Khadijah , Amin Hanudin 
Published: October 2019

Purpose
The purpose of this study is to examine the impacts of price fairness and Islamic altruism on the Islamic mortgage adoption along with theory of planned behaviour’s (TPB’s) constructs (i.e. attitude, subjective norm and perceived behavioural control). Attitude is also analysed as a mediator in this study.

Design/methodology/approach
Using TPB as a baseline theory, this study analyses the Islamic mortgage adoption involving a total of 281 Muslim consumers in Malaysia using partial least squares.

Findings
The results indicate that attitude, subjective norm, perceived behavioural control and price fairness significantly influence Muslim bank customers’ intention to choose Islamic home financing products. Other interesting findings are also provided.

Research limitations/implications
This study contains three limitations that include the geographical constraint, respondents’ selection and the limited number of factors used.

Practical implications
The results obtained can serve as a guideline for bank managers or marketers to generate better strategies, which are dynamic to improve the acceptance rate of Islamic mortgage.

Originality/value
This study extends the TPB flexibility to integrate with price fairness and Islamic altruism in the Islamic mortgage adoption context.
Designing with maritime heritage: adaptive re-use of small-scale shipyards in northwest Europe
Authors: Hettema Jelle , Egberts Linde 
Published: October 2019

Purpose
The purpose of this paper is to describe the different design approaches architects take towards the adaptive reuse of small-scale shipyards. Thereby giving a proposition for future projects by giving insight in how others preceded and showcasing different possibilities.

Design/methodology/approach
The research is based on a literary review in combination with a case study, following one main question: What architectural approaches do architects employ in redesigning nineteenth- and twentieth century dockyards in Northern Europe and how do these approaches consider the history of building and context? First, this paper researches the history of adaptive reuse. Additionally, the historical and cultural context of shipyards is researched. Finally, a case study is done linking theory with practice. Selected cases are: Kromhout shipyard in Amsterdam, Verftet Ny-Hellesund in Ny-Hellesund and the Maritime Museum in Helsingør.

Findings
Four approaches to adaptive re-use were distinguished in the cases: differentiation, continuation, cultivation and optimisation. Each has its own implications for the design and the chosen approach is ultimately related to the important heritage values of each individual shipyard. Heritage professionals proved to have a great say, in the early stages of the adaptation process, in which the adaptive reuse approach was chosen.

Research limitations/implications
This comparative research enables an in-depth analysis and comparison and thorough qualitative understanding. It however limits the insight in the representativeness of these cases.

Originality/value
This paper compares the adaptive reuse of small-scale shipyards in an international perspective. It offers insight into the patterns, principles and context of the architectural reuse of this underexposed industrial heritage.
Research opportunities for determining the elements of early trust in virtual teams
Authors: Gardner Ross , Kil Ad , van Dam Nick 
Published: October 2019

PurposeThis paper aims to analyze cognitive-based trust development during the beginning phase of virtual teams (VT) before any trustor’s firsthand, knowledge-based trust of a trustee can develop. At this phase, early cognitive trust development is largely an individual construct that can help set the tone for subsequent phases and may also influence final VT effectiveness and performance.Design/methodology/approachThis study begins with an analysis of cognitive-based trust and trust in VT and then focuses on the models and antecedents of early trust development in VT.FindingsThe conclusion offers a precise visualization of the research on early trust development in VT that identifies new research opportunities, particularly valuable for new field research.Research limitations/implicationsThis literature review could be useful to both researchers of early trust formation in VTs and to organizations that use VTs as a part of their workforce. The figures and tables produced in this literature could be useful to researchers of early trust development in VTs in two areas. First, researchers can use this information to quickly identify the academic literature associated with each component of early trust models, the type of research conducted for each component. Second, new research opportunities based on this sample for each component of the early trust model is clearly identified.Practical implicationsOrganizations need to ensure that members of VTs can form quickly and operate effectively within a short period. Identifying factors that may influence early trust formation could give managers and VT members an understanding of the importance of trust development in the early stages of VTs and how this may ultimately influence a VTs performance, effective teamwork and productivity.Originality/valueThe conclusion offers a precise visualization of the research on early trust development in VT that identifies new research opportunities, particularly valuable for new field research.
Increasing the scope of assurance research: new lines of inquiry and novel theoretical perspectives
Authors: Tyson Tom , Adams Carol A. 
Published: October 2019

PurposeTheorizing in the extant sustainability assurance literature is limited. This paper aims to identify apposite organizational theories from related fields which scholars could apply to sustainability assurance research. Through the introduction of theoretical perspectives new to the field, the authors seek to extend current research.Design/methodology/approachA literature review was undertaken and papers using theory to examine research questions concerned with sustainability assurance and business sustainability issues more broadly were categorized by theory and sub area of focus. The authors then considered how organizational theories used in other areas of business sustainability research might augment the current paucity of theorizing applied in sustainability assurance research, thereby opening up new research possibilities.FindingsThe review identified gaps in current theorizing in sustainability assurance research and theoretical frameworks which have the potential to augment research avenues in sustainability assurance, enhance the way researchers interpret their data and increase the understanding of sustainability assurance decisions.Practical implicationsInnovation in sustainability assurance research may lead to developments in sustainability assurance practice, which enhances the credibility of sustainability reports. It will inform ongoing debate regarding whether sustainability assurance should be mandatory, whether a specific reporting format and level of assurance should be prescribed, how the practice can be developed and whether alternatives to enhancing the credibility of sustainability reports need to be found.Social implicationsEnhanced theorizing may shed light on whether sustainability assurance enhances the credibility of sustainability disclosures and whether it leads, or fails to lead, to real improvements in preparers' sustainability-related practices.Originality/valueBy identifying theories which could be applied to sustainability assurance research, this paper facilitates the development of new avenues of research and new ways of interpreting data from the field.
Perspectives of individuals receiving occupational therapy services through the National Disability Insurance Scheme: Implications for occupational therapy educators
Authors: Barclay Linda , Callaway Libby , Pope Kirsty 
Published: October 2019

AbstractIntroductionWith the introduction of the National Disability Insurance Scheme (NDIS) in Australia, occupational therapy graduates need to be adequately prepared to support service users in this new policy context. There is, however, limited research informed by service users themselves to inform contemporary occupational therapy curriculum redesign. The aims of this study were: (a) to explore the experience of occupational therapy service provision from the perspective of service users with lived experience of disability; (b) to gain an understanding of the perceptions of people with lived experience of disability regarding the NDIS and whether it will change how they work with occupational therapists; (c) to gain an understanding of the perspectives of people with lived experience of disability regarding the NDIS, and how this influences curriculum content for occupational therapy education.MethodsA pragmatic qualitative design, underpinned by the constructivist paradigm was utilised. Demographic surveys and semi‐structured interviews were completed with 10 participants who were purposively recruited. Peer debriefing and use of an audit trail were undertaken to enhance the rigour of the analysis.ResultsThree themes were identified: (a) Occupational therapists as gatekeepers for equipment provision; (b) experience of the NDIS (Knowledge and understanding of the NDIS; Uncertainty regarding the NDIS; Choice and control in the NDIS); (c) curriculum content for occupational therapy.ConclusionThe insights provided by the people with lived experience in this study inform key areas of focus for occupational therapy curriculum to adequately prepare graduates to work in the evolving NDIS environment. Involving service users in an authentic manner in curriculum design, content delivery and student assessment is crucial for “real‐world” applicability of student education.