bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Segmentation of the Right Posterior Sector of the Liver
Authors: Minami Takayuki , Ebata Tomoki , Yokoyama Yukihiro , Igami Tsuyoshi , Mizuno Takashi , Yamaguchi Junpei , Onoe Shunsuke , Watanabe Nobuyuki , Nagino Masato 
Published: October 2019

AbstractBackgroundThe border between segments VI and VII of the right posterior sector of the liver is controversial owing to lack of anatomical landmarks. This study aimed to examine the segmentation of the right posterior sector.MethodsUsing three‐dimensional software, ramification type of the right posterior portal vein (RPPV) was analysed in 100 patients.ResultsA bow‐shaped anatomy, in which the RPPV exhibits a downward convex bow shape with several ramifications, was found in 50 patients. A bifurcation anatomy, in which the RPPV bifurcates into the cranial and caudal branches, was observed in 45 patients. In the bow‐shaped anatomy, setting the segmentation was difficult due to lack of definite landmarks; thus, the downward portal branches were determined as segment VI branches, while horizontal and upward branches were determined as segment VII branches. In the bow‐shaped anatomy, the incidence of full exposure of a thick branch of the right hepatic vein on virtual transection surface was 60.0%, while in the bifurcation anatomy, it was only 11.1%. No relations were observed between RPPV anatomy and main PV/right hepatic vein anatomy. The volumes of segments VI and VII were equal in both the bow‐shaped and bifurcation anatomy.ConclusionsThe bow‐shaped and bifurcation types are commonly observed in RPPV anatomy. In the bifurcation anatomy, the right posterior sector is divided into segments VI and VII. In the bow‐shaped anatomy, setting the segmentation was difficult, thus it may be compelled to be arbitrarily determined.
Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy
Authors: Braat A. J. A. T. , Ahmadzadehfar H. , Kappadath S. C. , Stothers C. L. , Frilling A. , Deroose C. M. , Flamen P. , Brown D. B. , Sze D. Y. , Mahvash A. , Lam M. G. E. H. 
Published: October 2019

Abstract

Purpose
Peptide receptor radionuclide therapy (PRRT) and radioembolization are increasingly used in neuroendocrine neoplasms patients. However, concerns have been raised on cumulative hepatotoxicity. The aim of this sub-analysis was to investigate hepatotoxicity of yttrium-90 resin microspheres radioembolization in patients who were previously treated with PRRT.

Methods
Patients treated with radioembolization after systemic radionuclide treatment were retrospectively analysed. Imaging response according to response evaluation criteria in solid tumours (RECIST) v1.1 and clinical response after 3 months were collected. Clinical, biochemical and haematological toxicities according to common terminology criteria for adverse events (CTCAE) v4.03 were also collected. Specifics on prior PRRT, subsequent radioembolization treatments, treatments after radioembolization and overall survival (OS) were collected.

Results
Forty-four patients were included, who underwent a total of 58 radioembolization procedures, of which 55% whole liver treatments, at a median of 353 days after prior PRRT. According to RECIST 1.1, an objective response rate of 16% and disease control rate of 91% were found after 3 months. Clinical response was seen in 65% (15/23) of symptomatic patients after 3 months. Within 3 months, clinical toxicities occurred in 26%. Biochemical and haematological toxicities CTCAE grade 3–4 occurred in ≤ 10%, apart from lymphocytopenia (42%). Radioembolization-related complications occurred in 5% and fatal radioembolization-induced liver disease in 2% (one patient). A median OS of 3.5 years [95% confidence interval 1.8–5.1 years] after radioembolization for the entire study population was found.

Conclusion
Radioembolization after systemic radionuclide treatments is safe, and the occurrence of radioembolization-induced liver disease is rare.

Level of Evidence
4, case series.
Electro-optic sensor for static fields
Authors: Grasdijk J. O. , Bai X. F. , Engin I. , Jungmann K. , Krause H. J. , Niederländer B. , Offenhäuser A. , Repetto M. , Willmann L. , Zimmer S. 
Published: October 2019

Abstract
A sensor has been developed for low frequency and DC electric fields E. The device is capable of measuring fields with $$\varDelta \mathrm{E}= 4$$ΔE=4 (1) V/cm resolution. It is based on a Y-cut Z-propagation lithium niobate electro-optic crystal. For a particular commercially available bare crystal, we achieved an in air time constant $$\tau _\mathrm{c}(\mathrm air)= 6.4(1.8)$$τc(air)=6.4(1.8) h for the decay of the electro-optic signal. This enables field monitoring for several hours. As an application, we demonstrated that a constant electric field $$E^{\mathrm{ext}} = 640$$Eext=640 V/cm applied via external electrodes to a particular spherical glass container holding an Xe/He gas mixture decays inside this cell with a time constant $$\tau _{E}^{\mathrm{glass}} = 2.5(5)$$τEglass=2.5(5) h. This is sufficient for the needs of experiments searching for a permanent electric dipole moment in $$^{129}$$129Xe. An integrated electric field sensor has been constructed which is coupled to a light source and light detectors via optical fibers. The sensor head does not contain any electrically conducting material.
Effects of single-nucleotide polymorphisms in the mTORC1 pathway on the risk of brain metastasis in patients with non-small cell lung cancer
Authors: Xu Yiquan , Huang Yina , Weng Lihong , Zheng Jiankun , Huang Yi , Lin Ying , Zhao Yunan , Li Hongru , Chen Yusheng 
Published: October 2019

Abstract
Purpose
The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway plays a vital role in cancer development and progression. This study aimed to investigate the relationship between genotype variants in mTORC1 pathway and the risk of brain metastasis (BM) in patients with non-small cell lung cancer (NSCLC).

Methods
We extracted genomic DNA from blood samples of 501 NSCLC patients and genotyped eight single-nucleotide polymorphisms (SNPs) in three core genes [mammalian target of rapamycin (mTOR), mammalian lethal with sec-13 protein 8 (mLST8) and regulatory-associated protein of mTOR (RPTOR)] of the mTORC1 pathway. The associations between these SNPs and the risk of BM development were assessed.

Results
The AG/GG genotype of mLST8:rs26865 and TC/CC genotype of mLST8:rs3160 were associated with an increased risk of BM [hazard ratios (HR) 2.938, 95% confidence interval (CI) 1.664–5.189, p < 0.001 and HR = 2.490, 95% CI = 1.543–4.016, p < 0.001, respectively]. These risk polymorphisms had a cumulative effect on BM risk, with two risk genotypes exhibiting the highest increased risk (p < 0.001). Furthermore, these risk SNPs were associated with the lymph node metastasis (N2/3), body mass index (BMI) (≥ 25 kg/m2), high level of squamous cell carcinoma (SCC) antigen and Ki-67 proliferation index. Moreover, patients with AG/GG genotype of mLST8:rs26865 had significantly lower median overall survival than those with AA genotype (12.1 months versus 21.6 months, p = 0.04).

Conclusions
Our results indicate that polymorphisms in mTORC1 pathway were significantly associated with increased risk of BM and may be valuable biomarkers to identify NSCLC patients with a high risk of BM.
On Hopf bifurcation in the problem of motion of a heavy particle on a rotating sphere: the viscous friction case
Authors: Kuleshov A. S. , Shalimova E. S. , Steindl A. 
Published: October 2019

Abstract
We investigate the Hopf bifurcation of a mass on a rotating sphere under the influence of gravity and viscous friction. After determining the equilibria, we study their stability and calculate the first Lyapunov coefficient to determine the post-critical behavior. It is found that the bifurcating periodic branches are initially stable. For several inclination angles of the sphere’s rotation axis, the periodic solutions are calculated numerically, which shows that for large inclination angles turning points occur, at which the periodic solutions become unstable. We also investigate the limiting case of small friction coefficients, when the mass moves close to the equator of the rotating sphere.
Does certification improve hired labour conditions and wageworker conditions at banana plantations?
Authors: van Rijn Fédes , Fort Ricardo , Ruben Ruerd , Koster Tinka , Beekman Gonne 
Published: October 2019

AbstractCertification of banana plantations is widely used as a device for protecting and improving socio-economic conditions of wageworkers, including their incomes, working conditions and—increasingly—voice [related to labour relations and workplace representation]. However, to date, evidence about the effectiveness of certification in these domains is scarce. We collected detailed field data on (1) economic benefits for improving household income, (2) social benefits for labour practices, and (3) the voice of wageworkers focusing on identity and identification issues amongst wageworkers at Fairtrade certified banana plantations and comparable, non-certified plantations in the Dominican Republic. We used different types of regression models to identify significant relationships. Econometrical analysis of survey results complemented by field observations and outcomes from in-depth stakeholder interviews indicate that the impact of Fairtrade certification on wageworkers’ economic benefits is rather limited. However, the impact on the voice of wageworkers (job satisfaction, sense of ownership, trust), is more evident. On Fairtrade certified plantations workers are more satisfied with the course of life and better represented. Thus while the additional value of Fairtrade certification on primary wages seems limited, Fairtrade has relevant positive effects on the labour force, particularly by delivering in-kind benefits, offering a sense of job-security, improving voice and enabling private savings. Benefits of (Fairtrade) certification, but also other interventions with a similar purpose, might therefore not be discerned in terms of economic benefits such as wages or basic labour conditions that are under direct control of (inter)national law, but they should be identified in terms of social benefits and improved norms of conduct for wageworker engagement.
The Inclusiveness and Emptiness of Gong Qi: A Non-Anglophone Perspective on Ethics from a Sino-Japanese Corporation
Authors: Dai Wenjin , Gosling Jonathan , Pye Annie 
Published: October 2019

Abstract
This article introduces a non-Anglophone concept of gong qi (communal vessel, 公器) as a metaphor for ‘corporation’. It contributes an endogenous perspective from a Sino-Japanese organizational context that enriches mainstream business ethics literature, otherwise heavily reliant on Western traditions. We translate the multi-layered meanings of gong qi based on analysis of its ideograms, its references into classical philosophies, and contemporary application in this Japanese multinational corporation in China. Gong qi contributes a perspective that sees a corporation as an inclusive and virtuous social entity, and also addresses the elusive, implicit, and forever evolving nature of organizational life that is rarely noticed. We propose gong qi can be applied in other organizations and wider cultural contexts to show a new way of seeing and understanding business ethics and organization. Rather than considering virtue as a list of definable individual qualities, we suggest that the metaphor of gong qi reveals how virtue can be experienced as indeterminate, yet immanently present, like the substance of emptiness. This, then allows us to see the virtue of immanence, the beauty of implicitness, and hence, the efficacy of gong qi.
Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders
Authors: Rutigliano Grazia , Zucchi Riccardo 
Published: October 2019

AbstractWe provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a small genomic region of 108 kb located in chromosome 6q23, which has been consistently identified by linkage analyses as a susceptibility locus for schizophrenia and affective disorders. Most TAARs are expressed in brain areas involved in emotions, reward and cognition. TAARs are activated by endogenous trace amines and thyronamines, and evidence for a modulatory action on other monaminergic systems has been reported. Therefore, linkage analyses were followed by fine mapping association studies in schizophrenia and affective disorders. However, none of these reports has received sufficient universal replication, so their status remains uncertain. Single nucleotide polymorphisms intaarshave emerged as susceptibility loci from genome-wide association studies investigating migraine and brain development, but none of the detected variants reached the threshold for genome-wide significance. In the last decade, technological advances enabled single-gene or whole-exome sequencing, thus allowing the detection of rare genetic variants, which may have a greater impact on the risk of complex disorders. Using these approaches, severaltaars(especiallytaar1) variants have been detected in patients with mental and metabolic disorders, and in some cases, defective receptor function has been demonstrated in vitro. Finally, with the use of transcriptomic and peptidomic techniques, dysregulations of TAARs (especially TAAR6) have been identified in brain disorders characterized by cognitive impairment.
Photogeneration of reactive oxygen species over ultrafine TiO2 particles functionalized with rutin–ligand induced sensitization and crystallization effects
Authors: Łabuz Przemysław , Gryboś Joanna , Pietrzyk Piotr , Sobańska Kamila , Macyk Wojciech , Sojka Zbigniew 
Published: October 2019

AbstractInteraction of amorphous and crystalline TiO2ultrafine particles (2–6 nm) with rutin results in the formation of colored nanomaterials of an excellent dispersity and enhanced colloidal stability in aqueous media. The FTIR and Raman spectra confirmed attachment of the rutin ligand via vicinal hydroxyl groups in a catechol-like fashion. The binding of rutin to amorphous TiO2gives rise to spontaneous crystallization of the parent nanoparticles into hydrogen titanates (H2Ti3O7and H2Ti12O25). Such structural transformations result in photosensitization toward visible light with enhanced efficiency of the charge separation and interfacial charge transfer processes, confirmed by detailed photoelectrochemical studies of the examined nanomaterials. The effectiveness of the photocatalytic ROS generation reactions was also strongly influenced by hydrogen peroxide, which plays a double role of a reactant prone to reduction and generation of hydroxyl radicals or a redox agent destroying the intra-band gap electronic states, suppressing thereby charge recombination. The photoinduced charge transfer processes lead to generation of various reactive oxygen species, which were detected by EPR using DMPO spin trap (HOO·detection) and in the reaction with terephthalic acid acting as a chemical scavenger (HO·detection). Complexation of TiO2particles with rutin shifts the photogeneration of hydroperoxyl (HOO·) and hydroxyl (HO·) radicals toward visible light (λ > 400 nm). A triple effect of rutin attachment to titania was established. It consists in pronounced photosensitization, promotion of crystallization and enhancement of the colloidal stability of ultrafine titania particles. Environmental implications of these assets on the photoinduced redox reactions with hydrogen peroxide in aqueous solutions upon UV or visible light irradiation were also discussed.
The Development of the Internalization of Sociocultural Body Ideals Scale Using Items From the Sociocultural Attitudes Towards Appearance Questionnaire: Validity, Reliability, and Measurement Invariance Testing
Authors: Sicilia Alvaro , Granero-Gallegos Antonio , Alcaraz-Ibáñez Manuel , Griffiths Mark D. , Sánchez-Gallardo Isabel , Medina-Casaubón Jesús 
Published: October 2019

AbstractEating disorders and body image disturbance are known to result in unhealthy consequences. When attempting to understand the etiology and management of these disorders, sociocultural models of body image disturbance and disordered eating have been predominant. The objective of the present study was to develop and validate the Internalization of Sociocultural Body Ideals Scale (ISBIS), a psychometric instrument that utilizes items from various versions of the Sociocultural Attitudes Towards Appearance Questionnaire (SATAQ). The ISBIS was developed to overcome some of the limitations found in existing instruments (including the SATAQ) that assess the internalization of sociocultural body ideals. The sample comprised 1130 students aged between 10 and 14 years. The psychometric properties of the ISBIS were examined using different analyses. The results supported the eight-item structure: four items for thin body ideal internalization and four items for thin body muscular/athletic internalization. The structure showed invariance to gender and achieved acceptable internal consistency and temporal stability indexes. Controlling for gender and body mass index, the results also showed that the internalization of the thin body ideal positively predicted social-physique anxiety in a statistically significant way. The results provide empirical evidence that the ISBIS is a reliable and valid instrument for assessing sociocultural body ideals in Spanish preadolescents.
Exploring enabling resources for place-based social entrepreneurship: a participatory study of Green Care practices in Finland
Authors: Moriggi Angela 
Published: October 2019

Abstract
Enabling resources are the array of tangible and intangible assets that social entrepreneurs mobilize or create to bring forward novel place-based initiatives, to respond to unmet sustainability challenges and ideally contribute to virtuous processes of socio-economic transformation. Understanding the role of resources in constraining or enabling the development of social enterprises holds important implications not merely for the initiatives, but also for the places where they are embedded. Existing studies fail to provide a comprehensive, empirically grounded account of resources for place-based social entrepreneurship. This paper aims to fill this gap, by exploring the array of resources that enable and constrain the development of Green Care practice, i.e., nature-based activities with a social innovation purpose. Three communities of Finnish practitioners—a nature-tourism company, a care farm, and a biodynamic farm—were involved over the span of 3 years in research activities conducted with an in-depth qualitative approach. Participants were engaged in several stages of iterative learning combining conventional and action-research methods: semi-structured interviews, participatory mapping, and a co-creation workshop. Results show that entrepreneurs resort to a great variety of enabling resources, inclusive of both tangible and intangible assets, that are only marginally considered by relevant literature. Based on these findings, the paper proposes a novel set of enabling resources, comprehensive of nine clusters: infrastructural, institutional, material, place-specific, organizational culture-related, social, ethical, affective, and competence-related. Two concluding insights can be inferred: understanding resources is paramount to grasp possibilities and challenges of place-based entrepreneurship; in-depth participatory processes are needed for a thorough and grounded investigation of enabling resources in places.
The second official report from Japanese registry for mechanical assisted circulatory support (J-MACS): first results of bridge to bridge strategy
Authors:   the J-MACS investigators, Kinugawa Koichiro , Nishimura Takashi , Toda Koichi , Saiki Yoshikatsu , Niinami Hiroshi , Nunoda Shinichi , Matsumiya Goro , Nishimura Motonobu , Arai Hirokuni , Morita Shigeki , Yanase Masanobu , Fukushima Norihide , Nakatani Takeshi , Sakata Yasushi , Ono Minoru 
Published: October 2019

Abstract

Background
The Japanese registry for mechanical assisted circulatory support (J-MACS) is a prospective registry to collect all data of implantable left ventricular assist device (LVAD) (and part of paracorporeal VAD) established in 2010. The first analytical report was published in 2017. The organization running J-MACS was used to be the pharmaceuticals and medical devices agency (PMDA), but has been changed to the council for clinical use of ventricular assist device related academic societies in 2017.

Methods
Since 2018, we changed the analytical methods as follows: first, we eliminated paracorporeal VAD from the analysis. Second, we included not only primary implantation but bridge to bridge (BTB) implantation of LVAD. Third, we added the analyses of adverse events that were not included in the previous analysis.

Results
As of Oct 2018, 711 primary LVAD implants and 168 BTB implants were enrolled. Survival rate of primary LVAD was 93% at 360 days and 91% at 720 days, and that of BTB was 86% at 360 days and 82% at 720 days.

Conclusion
We first reported the results of BTB in the second official report of J-MACS. The prognosis after LVAD implantation has been kept good in Japanese circumstances.
Colorectal cancer survivors only marginally change their overall lifestyle in the first 2 years following diagnosis
Authors: van Zutphen Moniek , Boshuizen Hendriek C. , Kok Dieuwertje E. , van Baar Harm , Geijsen Anne J. M. R. , Wesselink Evertine , Winkels Renate M. , van Halteren Henk K. , de Wilt Johannes H. W. , Kampman Ellen , van Duijnhoven Fränzel J. B. 
Published: October 2019

AbstractPurposeA healthy lifestyle after colorectal cancer (CRC) diagnosis may improve prognosis. Data related to lifestyle change in CRC survivors are inconsistent and potential interrelated changes are unknown.MethodsWe assessed dietary intake, physical activity, body mass index (BMI), waist circumference, and smoking among 1072 patients diagnosed with stages I–III CRC at diagnosis, 6 months and 2 years post-diagnosis. An overall lifestyle score was constructed based on the 2018 World Cancer Research Fund/American Institute of Cancer Research recommendations (range 0–7). We used linear mixed models to analyze changes in lifestyle over time.ResultsParticipants had a mean (± SD) age of 65 ± 9 years and 43% had stage III disease. In the 2 years following CRC diagnosis, largest changes were noted for sugary drinks (− 45 g/day) and red and processed meat intake (− 62 g/week). BMI (+ 0.4 kg/m2), waist circumference (+ 2 cm), and dietary fiber intake (− 1 g/day) changed slightly. CRC survivors did not statistically significant change their mean intake of fruits and vegetables, alcohol, or ultra-processed foods nor did they change their physical activity or smoking behavior. Half of participants made simultaneous changes that resulted in improved concordance with one component as well as deteriorated concordance with another component of the lifestyle score. Overall lifestyle score changed from a mean 3.4 ± 0.9 at diagnosis to 3.5 ± 0.9 2 years post-diagnosis.ConclusionsCRC survivors hardly improve their overall lifestyle after diagnosis.Implications for Cancer SurvivorsGiven the importance of a healthy lifestyle, strategies to effectively support behavior changes in CRC survivors need to be identified.