bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant Laparoscopic Hiatal Hernia Repair With Cholecystectomy: A Multicentric Study
Authors: zarogoulidis paul , Preda Silviu-Daniel , Konstantinos Sapalidis , Bințintan Vasile Virgil , Cristian Daniel Alin , Bică Marius , Pătrașcu Ștefan , Pantea Stelian , Patru Daniela , Șurlin Marin Valeriu 
Published: June 2020

Abstract
Introduction Concomitant surgery refers to performing two or more surgical operations on one patient under the same anesthesia. Patients and Methods We performed a retrospective multicentric study from October 2016 to October 2019, analyzing patients who underwent laparoscopic hiatal hernia repair. We extracted data of patients who underwent concomitant laparoscopic surgery for both hiatal hernia repair and cholecystectomy in the following Clinics: 1st Clinic of Surgery of Craiova Emergency Clinical County Hospital, “Colțea” Hospital, 3rd Clinic of Surgery of Cluj-Napoca and 3rd Surgery Clinic of University General Hospital of Thessaloniki and identified 20 patients who underwent hiatal hernia repair and had an added cholecystectomy. Allocation of data by hiatal hernia type showed 6 type IV hernia (complex hernia), 13 type III hernias (mixed type) and 1 type I hernia (sliding hernia). Out of the 20 cases analyzed, 19 were chronic cholecystitis and one patient presented with acute cholecystitis.Average operating time was 168 minutes. Blood loss was minimum. Cruroraphy was performed in all cases, mesh reinforce was added in 5 cases, and fundoplication was added in all cases: 3 Toupet, 2 Dorr and 15 Floppy-Nissen. Fundopexy was routinely added in cases with Toupet fundoplication. Cholecystectomy was performed in the following manner: 19 retrograde, 1 bipolar. Results All patients had favorable postoperative evolution. Patient follow up was at 1 month, 3 months and 6 months, with no sign of recurrence for hiatal hernia (anatomical or symptomatic) and no postcholecystectomy syndrome. In conclusion concomitant laparoscopic hiatal hernia repair and cholecystectomy is a safe and feasible option for patients with indication of surgery for both pathologies.
Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions
Authors: pan jianyuan , Chen Zhenfei , Zhou Gaoliang , Feng Jun , Zhang Jing 
Published: June 2020

Abstract
Objective: Cystatin C (Cys C) has been proposed as a useful biomarker of early impaired kidney function and predictor of mortality risk. The present analysis is to investigate the association of serum Cystatin C with the severity of coronary artery lesions, Gensini score (GS) and the risk of CAD.Methods: 682 CAD patients (230 females, 452 males; mean age 62.6±10.7 years, range from 31 to 86 years) and 135 healthy controls (41 females, 94 males; mean age 58.0±10.3 years, range from 38 to 84 years) were recruited in the current study. ELISA was applied to measure serum Cystatin C levels. Estimated glomerular filtration rate (eGFR) and Gensini score were calculated. Results: Serum TC, LDL-C, UA, Cystatin C and HCY were significantly elevated in CAD patients compared to healthy controls. There were significant differences regarding to Cystatin C, eGFR and Gensini score among different type of CAD patients, of which AMI group had an elevated serum Cystatin C, LDL-C, HCY and Gensini score than the other two groups. When stratified by the quartiles of Cystatin C, we found that age, proportion of male patients and hypertension and diabetes, HCY and Gensini score were increased in Quartile fourth groups than in other quartile groups. Spearman's correlation test revealed positive relationship between Cystatin C, HCY and Gensini score. Multivariate logistic regression analysis revealed that serum Cystatin C level, presence of hypertension and diabetes, HCY, age and male were the risk factors for coronary artery lesions.Conclusions: In summary, our results suggested that Cystatin C is a promising clinical biomarker that provides complementary information to the established risk determinants. The serum Cystatin C level is strongly associated with Gensini score and could be used to evaluate the severity of coronary artery lesions.
Prognostic significance of platelet-lymphocyte ratio in extrapulmonary neuroendocrine carcinoma
Authors: Kim Hyeon-Jong , Bae Woo Kyun , Lee Kang Han , Hwang Eu-Chang , Bang Hyun-Jin , Shim Hyun Jeong , Cho Sang Hee , Chung Ik-Joo , Hwang Jun Eul 
Published: June 2020

Abstract
Background

Extrapulmonary neuroendocrine carcinoma (EP-NEC) is an aggressive type of cancer with poor prognosis. Although several biological and histological markers are prognostic factors in NEC, the correlation between prognosis and systemic inflammation markers, such as the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), is unclear. This study evaluated the association between NLR or PLR and median overall survival (OS) or progression-free survival (PFS) in EP-NEC.
Methods

We retrospectively analyzed the clinical data from patients with unresectable or metastatic EP-NECs who received platinum-based chemotherapy at Chonnam National University Hwasun Hospital from August 2007 to March 2019. The cut-off values for NLR and PLR were 3 and 160, respectively.
Results

In total, 38 patients were analyzed. Both NLR and PLR at diagnosis had no significant associations with the response to initial chemotherapy. However, in the high-PLR group, median overall survival (OS) and progression-free survival (PFS) were poorer than those in the low-PLR group (high vs. low: 10.6 vs. 17.1 months, log-rank p = 0.007 and 4.1 vs. 9.3 months, log-rank p = 0.032, respectively). However, the high-NLR group had insignificantly poorer median OS and PFS than the low-NLR group. In the multivariate analysis, high PLR and LDH were independent prognostic factors for median OS and PFS.
Conclusions

High PLR was associated with shorter survival of EP-NEC patients receiving platinum-based chemotherapy. Therefore, PLR may be an independent prognostic factor in EP-NEC.
Prediction of Size of the COVID-19 Pandemic Using Wavelength Models: Cases of Turkey and World
Authors: Bulut Tevfik , Yıldız Mustafa Çağrı 
Published: June 2020

Abstract
The main purpose of the study is to predict the magnitude of the Covid-19 pandemic by using epidemiological wavelength models in Turkey and at international level. Therefore, firstly, the first 36 days of wavelengths based on the number of daily coronavirus cases in Turkey were calculated. In addition, 114 countries were compared in terms of Covid-19 wavelengths considering the cumulative number of the pandemic cases occured at the end of the first 36 days for evaluation on an equal plane. In the last part of the study, the wavelengths of 185 countries were examined comparatively based on the cumulative number of cases at the end of the time frame from the first epidemic case until 2020-04-16 (including that date). According to the findings of wavelength obtained in Turkey, it was observed that case wavelength on 2020-04-11, death and recovered case wavelength on 2020-04-16, and net wavelength on 2020-03-26 reached its peak. China was the country having the highest wavelength of case, death, and recovered case wavelengths in 114 countries at the end of the first 36 days since the first case occurred. In that country, wavelengths of case, death and recovered case were 33.6, 23.5 and 30.7, respectively. The first three countries with the highest net wavelength at the end of the first 36 days were Serbia (36.5), Netherlands (33.5) and Portugal (30.3), respectively. On the other hand, the country having the highest case and death wavelengths among 185 countries in the time interval from the first case until the date of 2020-04-16 (including that date) was the USA, and case and death wavelengths were 39.7 and 30.7, respectively. The country with the highest recovered case wavelength was China (33.3). The first 3 countries with the highest wavelengths are Canada (51.4), England (45.0) and Serbia (39.2), respectively.
WITHDRAWN: hnRNPM Deficiency Deteriorates Cognitive Function by Decreasing Synaptic Proteins
Authors: Akinyemi Akinsola Raphael , Li Dingfeng , Zhang Juan , Liu Qiang 
Published: June 2020

Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs), a wide sub-family within the diverse RNA-binding proteins family, contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, transcriptional, posttranscriptional and translational regulation. In this study, we report that alteration to the endogenous level of Heterogeneous nuclear ribonucleoprotein M (hnRNPM) in pyramidal cells of the CA1 hippocampal region of young wildtype mice brain leads to cognitive dysfunction. We further show that deficit to hnRNPM level impedes synaptic transmission while affecting the expression levels of pre- and post-synaptic markers following its binding to the 3´UTR of synaptophysin (SYP) and Postsynaptic Density Protein 95 (PSD95). In addition, we gathered that knockdown of hnRNPM affects the expression level of NeuN (Rbfox3), a protein essential for hippocampal neurogenesis and synaptogenesis. These further suggest that diminished level of hnRNPM could lead to synaptic dysfunction or deficits in neurogenesis and impaired cognitive functions as reported in NeuN homozygous knockout mice. Furthermore, we then show that hnRNPM binds directly and significantly to the 3´UTR of NeuN, synaptophysin and PSD95 to stabilize their mRNA. Our findings present a novel insight into the regulatory role of hnRNPM in synaptic transmission and cognitive functions.
Perceptions and knowledge of oncology patients of covid-19 infection in a developing country
Authors: Alami Arwa Y , Abdeen Gadeer , Sabbagh Rula El , Dabor Amneh 
Published: June 2020

Abstract
PurposeTo assess knowledge, beliefs, and measures followed by oncology patients in a developing country during the pandemic covid-10.Methods A survey conducted by phone calls to a group of patients treated at a cancer hospital, answers were recorded by the investigators. Data were analysed descriptively.Results Two hundred and one oncology patients answered the survey, mean age was 51.49 years; 66.2% were females, 49.2% of them were on active anticancer treatment. All patients knew of covid-19, 91%believed that it was contagious but only 46.3% thought they could become infected. While 75.1% believed that coming to the hospital increased the risk of infection, only 33.3% preferred to postpone their treatment. Only a minority thought that they will not seek medical treatment if they were infected with covid-19. Most of the participants followed preventive measures such as hand washing and use of disinfectants. Patients were followed by phone calls instead of clinical visits and 85.6% were satisfied with it.Conclusion: Study showed that most oncology patients are aware of the covid-19 pandemic, methods of spread and risk of infection. Most of them followed protective measures and adhered to social distancing. Patients were satisfied with phone calls as a replacement to clinical visits during the pandemic and their treatment plan was followed.
Crisis Management for Small Business during the COVID-19 Outbreak:Survival, Resilience and Renewal Strategies of Firms in Macau
Authors: ALVES Jose C , LOK Tan Cheng , LUO YuBo , HAO Wei 
Published: June 2020

Abstract
We know that small businesses are vulnerable to crisis, however little is still known about how they cope during long crisis as the COVID-19 pandemic. This paper provides a qualitative analysis of small businesses in Macau, China, in the months following the outbreak. We collected interview data from six local small firms. We found that the sudden decline in demand has the strongest impact on small firms. As compared with large firms, new startups and small firms show high flexibility in their reactions to the crisis, partly due to the low level of bureaucracy and limited social responsibility compliance. Among the various types of response strategies, all participant firms adopted flexible HR strategies. Other common survival strategies include the increase of product diversification, exploration of new markets, and increase of learning. We also found that some small businesses had a formal crisis plan and strategy before the outbreak, and these firms tend to have longer history, experience in dealing with crisis, and operate in more regulated sectors. Based on these results, we define five types of renewal and survival strategies for small businesses and propose a SME crisis resilience model.
Prognostic Function of Neutrophil-to-Lymphocyte Ratio in Patients with GEP-NEN: A Systematic Review and Meta-Analysis
Authors: Wang Yajie , Wen Bei , Zhang Yuxin , Dong Kangdi , Tian Shubo , Li Leping 
Published: June 2020

Abstract
Purpose: A high neutrophil-to-lymphocyte ratio (NLR) might be related to unfavorable prognosis. We sought to conduct a systematic review and meta-analysis of published studies exploring the relationship between NLR with the prognosis in patients with gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).Methods: The databases PubMed, Embase, and Web of Science were searched using words like 'neutrophil lymphocyte ratio', neuroendocrine tumors', and others through May 2020. We evaluated the significance of NLR on overall survival (OS) and recurrence-free survival (RFS) of patients with GEP-NEN in our study.Results: We gathered thirteen cohorts with 1598 cases. The pooled analysis revealed that a higher NLR related to worse OS (hazards ratio (HR): 4.59, 95% confidence interval (CI) 3.35-6.29, P < 0.00001) and poor RFS (HR: 4.05, 95% CI: 2.78–5.90, P＜0.00001) in patients with GEP-NEN.Conclusion: A high NLR can be considered a high-risk prognostic factor in GEP-NEN.
Metal contamination assessment in water column and surface sediments of a warm monomictic man-made lake: Sabalan Dam Reservoir, Iran
Authors: Aradpour Saber , Noori Roohollah , Tang Qiuhong , Bhattarai Rabin , Hooshyaripor Farhad , Hosseinzadeh Majid , Haghighi Ali Torabi , Klöve Björn 
Published: June 2020

Abstract
In this study, metal concentrations in the water column and surface sediment of the Sabalan Dam Reservoir (SDR) were determined. Moreover, heavy metal pollution index (HPI), contamination index (CI), heavy metal evaluation index (HEI), enrichment factor (EF), geo-accumulation index (Igeo), sediment quality guidelines (SQGs), consensus-based SQGs (C-BSQGs), and mean probable effect concentration quotients (mPECQs) were evaluated for water and sediments of SDR. It was observed that metal concentrations in river entry sediment were lower, but those in river entry water were higher than corresponding values in the vicinity of the dam structure. The HPI values of water samples taken from 10 m depth in the center of SDR exceeded the critical limit, due to high concentrations of arsenic. However, according to CI, the reservoir water was not contaminated. The HEI values indicated contamination of SDR water with metals at 10 m depth. A comparison of water quality indices revealed that HEI was the most reliable index in water quality assessment, while CI and HPI were not sufficiently accurate. For SQGs, As and Cu concentrations in sediments were high, but mPECQ, Igeo, and EF revealed some degree of sediment pollution in SDR. The calculated EF values suggested minor anthropogenic enrichment of sediment with Fe, Co, V, and Ni; moderate anthropogenic enrichment with As and Mn; and moderate to severe anthropogenic enrichment with Cu. A comparison of SQG values revealed that the threshold effect and probable effect levels were the most reliable metrics in the assessment of sediment toxicity. Statistical analysis indicated similarities between metal concentrations in the center of the reservoir and near to the dam structure, as a result of similar sediment deposition behavior at these points, while higher flow velocity at the river entry point limited deposition of fine particles and associated metals.
Dihydroorotate Dehydrogenase Inhibitors Promote Cell Cycle Arrest and Disrupt Mitochondria Bioenergetics in Ramos Cells
Authors: Kadir Mohamad F.A. , Othman Shatrah , Nellore Kavitha 
Published: June 2020

Background:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries.Objective:The effects of Brequinar Sodium (BQR) and 4SC-101 on lymphoblastoid cell lines were investigated.Methods:DHODH expression and cell proliferation inhibition of lymphoblastoid and lymphoma cell lines were analyzed using Western blot analysis and XTT assay, respectively. JC-1 probe and ATP biochemiluminescence kit were used to evaluate the mitochondrial membrane potential and ATP generation in these cell lines. Furthermore, we explored the cell cycle progression using Muse™ Cell Cycle Kit.Results:Ramos, SUDHL-1 and RPMI-1788 cells are fast-growing cells with equal expression of DHODH enzyme and sensitivity to DHODH inhibitors that showed that the inhibition of DHODH was not cancer-specific. In ATP depletion assay, the non-cancerous RPMI-1788 cells showed only a minor ATP reduction compared to Ramos and SUDHL-1 (cancer) cells. In the mechanistic impact of DHODH inhibitors on non-cancerous vs cancerous cells, the mitochondrial membrane potential assay revealed that significant depolarization and cytochrome c release occurred with DHODH inhibitors treatment in Ramos but not in the RPMI-1788 cells, indicating a different mechanism of proliferation inhibition in normal cells.Conclusion:The findings of this study provide evidence that DHODH inhibitors perturb the proliferation of non-cancerous cells via a distinct mechanism compared to cancerous cells. These results may lead to strategies for overcoming the impact on non-cancerous cells during treatment with DHODH inhibitors, leading to a better therapeutic window in patients.
Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review
Authors: Azimi Maryam , Zahedi Mohammad Javad 
Published: June 2020

Introduction:According to Rome IV, functional dyspepsia is diagnosed with the presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors, such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported the effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal medicine in FD.Methods:Electronic databases, including Pubmed, Scopus, Cochrane, Embase, Web of science and Ovid, were searched so as to find clinical articles related to dyspepsia and herbal medicine by July 2019. Our search strategies were traditional medicine, complementary and alternative medicine, herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials.Results:We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa, Pistatio Atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence, Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional dyspepsia.Conclusion:Many people use herbal and traditional remedies for the treatment of disorders such as gastrointestinal disorders, especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.
Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies
Authors: Ali Mahboob , Khan Momin , Zaman Khair , Wadood Abdul , Iqbal Maryam , Alam Aftab , Shah Sana , Ashfaq Ur Rehman  , Yousaf Muhammad , Rafique Rafaila , Khan Khalid Mohammed 
Published: June 2020

Background:
The inhibition of α-amylase enzyme is one of the best therapeutic approach for
the management of type II diabetes mellitus. Chalcone possesses a wide range of biological activities.

Objective:
In the current study chalcone derivatives (1-16) were synthesized and evaluated their inhibitory
potential against α-amylase enzyme.

Methods:
For that purpose, a library of substituted (E)-1-(naphthalene-2-yl)-3-phenylprop-2-en-1-ones
was synthesized by Claisen-Schmidt condensation reaction of 2-acetonaphthanone and substituted aryl
benzaldehyde in the presence of base and characterized via different spectroscopic techniques such as
EI-MS, HRESI-MS, 1H-, and 13C-NMR.

Results:
Sixteen synthetic chalcones were evaluated for in vitro porcine pancreatic α-amylase inhibition.
All the chalcones demonstrated good inhibitory activities in the range of IC50 = 1.25 ± 1.05 to 2.40 ±
0.09 μM as compared to the standard commercial drug acarbose (IC50 = 1.34 ± 0.3 μM).

Conclusion:
Chalcone derivatives (1-16) were synthesized, characterized, and evaluated for their α-
amylase inhibition. SAR revealed that electron donating groups in the phenyl ring have more influence
on enzyme inhibition. However, to insight the participation of different substituents in the chalcones on
the binding interactions with the α-amylase enzyme, in silico (computer simulation) molecular modeling
analyses were carried out.
Elaboration of Novel TTK1 Inhibitory Leads via QSAR-Guided Selection of Crystallographic Pharmacophores Followed By In Vitro Assay
Authors: Al-Sha'er Mahmoud A. , Taha Mutasem O. 
Published: June 2020

Introduction:
Tyrosine threonine kinase (TTK1) is a key regulator of chromosome segregation.
Recently, TTK targeting came into focus for the enhancement of possible anticancer therapies.

Objective:
In this regard, we employed our well-known method of QSAR-guided selection of the
best crystallographic pharmacophore(s) to discover considerable binding interactions that transfer
inhibitors into TTK1 binding site.

Methods:
Sixty-one TTK1 crystallographic complexes were used to extract 315 pharmacophore
hypotheses. QSAR modeling was subsequently used to choose a single crystallographic pharmacophore
that, when combined with other physicochemical descriptors, elucidates discrepancy in bioactivity
of 55 miscellaneous inhibitors.

Results:
The best QSAR model was robust and predictive (r2(55) = 0.75, r2LOO = 0.72 , r2press
against external testing list of 12 compounds = 0.67), Standard error of estimate (training set) (S)=
0.63 , Standard error of estimate (testing set)(Stest) = 0.62. The resulting pharmacophore and QSAR
models were used to scan the National Cancer Institute (NCI) database for new TTK1 inhibitors.

Conclusion:
Five hits confirmed significant TTK1 inhibitory profiles with IC50 values ranging between
11.7 and 76.6 mM.