bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengukuran Kinerja Mesin Perusahaan Menggunakan Overall Equipment Effectiveness Dan Usulan Perbaikan Menggunakan Diagram Sebab Akibat (Fish-Bone) Pada CV. Jati Makmur Pasuruan
Authors: Karismawan Fredo , Katias Puspandam 
Published: December 2020

This study aims to to know costs inflicted of a system of preventive maintenance and maintenance of the breakdown and its effect on downtime .The research was done in the lumber cv .Jati prosper with the qualitative study approach uses the descriptive . Procedures data collection in penellitian it has several stages of , namely the preliminary survey , theoretical survey , and field study . The result from research found that among januari until december 2010 OEE range 65,093% -81,175%.after research found that two factors majority affect OEE value in CV.Jati Makmur two factors is reduce speed losses and setup and adjustment losses with proportion 45,83% and 40,88%.
DETERMINAN KINERJA INVESTASI PERUSAHAAN ASURANSI SYARIAH DI INDONESIA PERIODE 2014-2018
Authors: Ilma Nafiatul , Filianti Dian 
Published: December 2020

ABSTRAKPenelitian ini menggunakan pendekatan kuantitatif dengan menggunakan jenis penelitian explanatory research. Populasi dalam penelitian ini adalah Perusahaan asuransi syariah di Indonesia yang terdaftar di Otoritas Jasa Keuangan periode 2014 – 2018. Teknik pengambilan sampel pada penelitian ini adalah purposive sampling dan diperoleh syariah 18 perusahaan asuransi syariah sebagai sampel. Penelitian ini menggunakan analisis regresi linear berganda. Hasil penelitian ini menunjukkan bahwa secara parsial company size dan volume of capital tidak berpengaruh signifikan sedangkan likuiditas, leverage, premium growth berpengaruh signifikan negatif sedangkan asset growth berpengaruh signifikan positif terhadap investment yield, secara simultan company size, likuiditas, asset growth, leverage, volume of capital, premium growth secara simultan berpengaruh signifikan terhadap investment yield.Kata Kunci: company size, liquidity, leverage, asset growth, volume of capital, premium growth, investment yield, takaful ABSTRACTThis research uses a quantitative approach using an explanatory research type. The population in this study is sharia insurance companies in Indonesia registered with the Financial Services Authority for the period 2014 - 2018. The sampling technique in this study was purposive sampling and 18 sharia insurance companies were obtained as samples. This study uses multiple linear regression analysis. The results of this study indicate that partially company size and volume of capital have no significant effect while liquidity, leverage, premium growth have a significant negative effect while asset growth has a significant positive effect on investment yield, simultaneously company size, liquidity, asset growth, leverage, volume of capital, premium growth simultaneously have a significant effect on investment yield.Keyword: company size, liquidity, leverage, asset growth, volume of capital, premium growth, investment yield, takaful
Changes in Practitioners’ Attitudes, Perceived Training Needs and Self-Efficacy over the Implementation Process of an Evidence-Based Parenting Program
Authors: Côté Marie-Kim , Gagné Marie-Hélène 
Published: December 2020

Abstract
Background: Evidence-based family support programs such as the Triple P – Positive Parenting Program have the potential to enhance the well-being of children and families. However, they cannot achieve their expected outcomes if insufficient attention is paid to the implementation process. It has been demonstrated that practitioners’ attitudes towards evidence-based programs (EBPs), perceived training needs and self-efficacy for working with parents influence implementation outcomes (e.g., program acceptability, adoption, adherence and sustainability). At the same time, the experience of being involved in the implementation process of an EBP could enhance practitioners’ perceptions of the initiative. This study aimed to assess changes in practitioner’s attitudes, perceived training needs and self-efficacy over a two-year EBP implementation process, in interaction with their appraisal of their organization’s capacity to implement the EPBMethods: In the province of Quebec, Canada, Triple P was implemented and evaluated in two communities. Ninety-nine practitioners from various organizations completed questionnaires shortly before their training in Triple P and two years later. Results: Findings show that practitioners who displayed more initial skepticism regarding their organization’s capacity to implement the program reported greater improvements in attitudes over time, while practitioners who showed more optimism at baseline reported a greater decrease in their perceived training needs. Practitioners’ self-efficacy increased moderately regardless of perceived organizational capacity. Conclusions: These results are encouraging given that more positive perceptions of EBPs could foster the systematic use of these programs in communities, for the potential benefit of a greater number of families.
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype&nbsp;in vitro
Authors: Raut Snehal , Patel Ronak , Al-Ahmad Abraham 
Published: December 2020

Abstract
Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disease. It is an irreversible condition marked by irreversible cognitive loss, commonly attributed to the loss of hippocampal neurons due to the formation of senile plaques and neurofibrillary tangles. Although the sporadic form is the most prevalent, the presence of familial form (involving several genes such as APP, PSEN1 and PSEN2) of the disease is commonly used as a model for understanding the pathophysiology of the disease. The aim of this study is to investigate the effect of mutation on PSEN1 and PSEN2 genes on the BBB function using induced pluripotent stem cells (iPSCs). Methods: iPSC lines from patients suffering from familial form of Alzheimer’s disease and harboring mutations in PSEN1 or PSEN2 were used in this study and compared to a control iPSC line. Cells were differentiated into brain microvascular endothelial cells (BMECs) following established differentiation protocols. Barrier function was assessed by measuring TEER and fluorescein permeability, drug transporters activity was assessed by uptake assay, glucose uptake and metabolism assessed by cell flux analyzer, mitochondrial potential by JC-1 and lysosomal acidification by acridine orange. Results: iPSC derived BMECs from the FAD patient presenting a mutation in PSEN1 gene showed impaired barrier function compared to the FAD patient harboring a mutation in PSEN2 and to control group. Such impaired barrier function correlated with poor tight junction complexes and reduced drug efflux pump activity. In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production. Finally, PSEN1- and PSEN2-BMECs showed an elevated secretion of Ab1-40 peptides compared to control-BMECs. Conclusion: Our study reports that iPSC-derived BMECs obtained from FAD patients showed impaired barrier properties and BMECs metabolism. In particular, PSEN1 mutation was associated with a more detrimental phenotype than the PSEN2 mutation, as noted by a reduced barrier function, reduced drug efflux pump activity and diminished glucose metabolism. Therefore, assessing the contribution of genetic mutations associated with Alzheimer’s disease will allow us to better understand the contribution of the BBB in dementia, but also other neurodegenerative diseases.
Parental Stress around Ophthalmological Health Conditions: A Systematic Review of Literature Protocol
Authors: SOUZA-SILVA JULIO CESAR , Martins Cleusa Alves , Garciazapata Marco Túlio Antonio , Barbosa Maria Alves 
Published: December 2020

Abstract
Background Parents can be psychologically impacted when children have eye diseases such as blindness, strabismus, and eye cancer. Stress can reduce the quality of parental care, and may be linked to the deterioration of parents’ and children’s mental and physical health, and family dynamics. No systematic literature review on parental stress in ophthalmology has been found to provide evidence synthesis capable of stimulating and defining new studies promoting research in this field. To address this important gap, the present review aims to synthesize evidence about approaches, methods, instruments, and results from research regarding ophthalmology-related parental stress. Methods Primary epidemiological observational studies should be original in addressing parental stress caused by ophthalmological health conditions in children, and their originality should be explained in both the summary and full text. They should present the characteristics of the study population, and the clinical and ophthalmic characterizations of children. MEDLINE (via Ovid), EMBASE, PsycINFO, Google Scholar, and Gray Literature (PsycEXTRA, NTIS and OpenSINGLE) will be searched. Controlled vocabulary, Boolean operators, and defined search strategies will be used. There will be no restrictions on the studies’ publication language, which will be selected in two screening stages. Two reviewers will independently retrieve full-text studies, assess methodological quality, and extract data. Data available through December 2021 will be considered for inclusion. Discussion The socioeconomic characterization of the participants, the identification of which ophthalmological diseases have been studied in relation to parental stress, and the knowledge of each instrument and methodology peculiarities potentially contribute to this study. The results may promote the development or enhancement of public policies focused on this specific theme, thereby providing the means for potential improvement of physical and mental health for parents and children with eye diseases.Systematic review registration The review protocol was registered in PROSPERO: number CRD42018094972.
Prevalence and risk factors of falls among community-dwelling older people: results from three consecutive waves of the national health interview survey in Taiwan
Authors: Tsai Yih-Jian , Yang Ping-Yen , Yang Yi-Ching , Lin Mau-Roung , Wang Ying-Wei 
Published: December 2020

Abstract
Background: An aging society incurs great losses due to fall-related injuries and mortalities. The foreseeable increased burden of fall-related injury among older people requires a regular nationwide study on the fall epidemic and prevention strategies. Methods: The fall epidemic was examined using data from three consecutive waves of the National Health Interview Survey (2005, 2009, and 2013). Common explanatory variables across these surveys included sociodemographic factors (age, sex, and difficulty in performing activities of daily living (ADL) or instrumental ADL), biological factors (vision, comorbidities, urinary incontinence, and depressive symptoms), and behavioral risk factors (sleeping pill use, and frequency of exercise). After the univariate and bivariate analyses, the prevalence of falls was investigated using multiple linear regression models adjusted for age group, sex, and year of survey. A multivariate logistic regression model for falls with adjustments for these common explanatory variables was established across three waves of surveys. The effect of fall prevention programs was examined with the effect size in terms of age-specific and sex-specific prevalence of falls and fall-related hospitalization rates during 2005 and 2009.Results: For each survey, there were consecutively 2,722; 2,900; and 3,200 respondents with a mean age of 75.1, 75.6, and 76.4 years, respectively. The multiple linear regression model yielded a negative association between the prevalence of falls and year of survey. Several sociodemographic and biological factors, including female sex, difficulty in performing one basic ADL, difficulty in performing two or more instrumental ADLs, unclear vision, comorbidities, urinary incontinence, and depressive symptoms, were significantly associated with falls. In contrast to the universal positive effect on the prevalence of falls among older adults, the effect size of fall-related hospitalization rates revealed a 2% relative risk reduction only for those aged 65-74 years, but deteriorated for those aged 75-84 (-10.9%).Conclusion: Although the decline in fall prevalence over time supports existing fall intervention strategies in Taiwan, the differential prevention effect and identification of risk factors in older people suggest the necessity of adjusting fall prevention programs.
A polypeptide D-TTK001 targeting HBx controls cccDNA against HBV
Authors: Zhang Xiaodong , Yuan Hongfeng , Zhang Shuai , Zhang Shuqin , Zhao Lina , Gao Hongwei , Yang Guang , Zhang Xuezhi , Yun Haolin , Shan Changliang , Liu Yunxia , Geng Yu , Zheng Wei , Gao Xiuzhu , Wang Xiaomei , Yuan Ying , Miao Zhenchuan , Yin Ming , Zhao Man , Wang Yufei , Wang Jiapei , Niu Junqi 
Published: December 2020

Abstract
Chronic infection of HBV is a serious global health issue. However, the HBV covalently closed circular DNA (cccDNA) cannot be completely cleaned in liver. Here, we engineer a novel polypeptide, termed D-TTK001, targeting HBV X protein (HBx) against HBV cccDNA. D-TTK001 is a D-type polypeptide, which has a high binding affinity to HBx. Interestingly, it is able to against HBV efficiently in primary human hepatocytes (PHHs) from three donors. D-TTK001 displays high activities against HBV, remarkably reducing the levels of cccDNA in the HBV-infected human liver-chimeric mice. Mechanically, D-TTK001 depresses cccDNA transcription by regulating the epigenetic modification of cccDNA minichromosome and disturbing the interaction of HBx with DDB1 in the cells. D-TTK001 decreases the levels of cccDNA by down-regulating MSL2, leading to the increase of APOBEC3B in liver. When combined with entecavir or interferon-α, D-TTK001 shows additive antiviral effects. Clinically, D-TTK001 is a strong candidate to clear cccDNA against HBV.
An African Tick Flavivirus Forming an Independent Clade Exhibits Unique Exoribonuclease-Resistant&nbsp;RNA Structures in the Genomic 3′-Untranslated Region
Authors: Harima Hayato , Orba Yasuko , Torii Shiho , Qiu Yongjin , Kajihara Masahiro , Eto Yoshiki , Matsuta Naoya , Hang’ombe Bernard , Eshita Yuki , Uemura Kentaro , Matsuno Keita , Sasaki Michihito , Yoshii Kentaro , Nakao Ryo , Hall William , Takada Ayato , Abe Takashi , Wolfinger Michael , Simmunza Martin , Sawa Hirofumi 
Published: December 2020

Abstract
Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals. Despite their importance to public health, there is limited epidemiological information on TBFV infection in Africa is limited. Herein, we report that a novel flavivirus, Mpulungu flavivirus (MPFV), was discovered in a Rhipicephalus muhsamae tick in Zambia. MPFV was found to be genetically related to Ngoye virus detected in ticks in Senegal, and these viruses formed a unique lineage in the genus Flavivirus. Analyses of dinucleotide contents of flaviviruses indicated that MPFV was similar to those of other TBFVs with a typical vertebrate genome signature, suggesting that MPFV may infect vertebrate hosts leading to significant public health problems. Bioinformatic analyses of the secondary structures in the 3′-untranslated regions (UTRs) revealed that MPFV exhibits unique exoribonuclease-resistant RNA (xrRNA) structures. Utilizing biochemical approaches, we clarified that two xrRNA structures of MPFV in the 3′-UTR could prevent exoribonuclease activity. In summary, our findings provide new information regarding the geographical distribution of TBFV and xrRNA structures in the 3′-UTR of flaviviruses.
Anxiety for the pandemic and trust in financial markets
Authors: Cerqueti Roy , Ficcadenti Valerio 
Published: December 2020

Abstract
The COVID-19 pandemic has generated a novel context of global financial distress. This paper enters the related scientific debate and focuses on the relationship between the anxiety felt by the population of a wide set of countries during the pandemic and the trust in the future performance of financial markets. Precisely, we move from the idea -- grounded on some recent literature contributions -- that the volume of Google searches about "coronavirus" can be considered as a proxy of the anxiety and, jointly with the stock index prices, can be used to produce indicators of the population mood -- in terms of pessimism and optimism -- at country level. We analyse the ``very high human developed countries'' according to the Human Development Index plus China and their respective main stock market indexes. Namely, we propose both a temporal and a global measure of pessimism and optimism and provide accordingly a classification of indexes and countries. The results show the existence of different clusters of countries and markets in terms of pessimism and optimism. Moreover, specific regimes along the time emerge, with an increasing optimism spreading during the mid of June 2020. Furthermore, countries with different government responses to the pandemic have experienced different levels of mood indicators, so that countries with less strict lockdown had a higher level of optimism.
β-catenin/LEF-1 Transcription Complex is Responsible for the Transcriptional Activation of LINC01278
Authors: Lin Shaojian , Zhang Weiwei , Shi Ziwen , Tan Langping , Zhu Yue , Li Honghao , Peng Xinzhi 
Published: December 2020

Abstract
Background: Our previous study shows that LINC01278 inhibits the development of papillary thyroid carcinoma (PTC) by regulating miR-376c-3p/DNM3 axis. However, the regulation mechanism of LINC01278 expression in PTC cells is still unclear. Methods: The luciferase reporter and ChIP assays were used to confirme the binding of LEF-1 to the putative promoter site of LINC01278. The RNA immunoprecipitation was used the enrichment of LINC01278 in β-catenin protein. Western blot was used to detected the expression of target proteins. Results: Firstly, the online PROMO algorithm determined a putative LEF-1 binding site on LINC01278 promoter. Then, the luciferase reporter and ChIP assays confirmed the binding of LEF-1 to the putative promoter site of LINC01278. Furthermore, the overexpression of β-catenin increased the binding of LEF-1 to the LINC01278 promoter, and the knockdown or overexpression of LEF-1 or β-catenin can affect the expression level of LINC01278. In addition, RNA immunoprecipitation showed that LINC01278 was enriched in β-catenin protein. RNA pulldown and western blot also confirmed that LINC01278 precipitated β-catenin in TPC-1 and BCPAP cells. Furthermore, the knockdown or overexpression of LINC01278 significantly affected the expression of β-catenin and targets of Wnt/β-catenin signaling pathway (CCND2, CyclinD1, MYC, and SOX4). Conclusion: In summary, we found the transcriptional activation of LINC01278 by the β-catenin/LEF-1 transcription factor, and the negative feedback regulation of LINC01278 on Wnt/β-catenin signaling pathway activation.
Plasticity in Plastid Redox Networks: Evolution of Glutathione-Dependent Redox Cascades and Glutathionylation Sites
Authors: Mueller-Schuessele Stefanie J. , Bohle Finja A. , Rossi Jacopo , Trost Paolo , Meyer Andreas J. , Zaffagnini Mirko 
Published: December 2020

Abstract
Background: Flexibility of plant metabolism is supported by redox regulation of enzymes via posttranslational modification of cysteine residues, especially in plastids. Here, the redox states of cysteine residues are partly coupled to the thioredoxin system and partly to the glutathione pool for reduction. Moreover, several plastid enzymes involved in reactive oxygen species (ROS) scavenging and damage repair draw electrons from glutathione. In addition, cysteine residues can be post-translationally modified by forming a disulfide with glutathione (S-glutathionylation), which protects thiol groups from further oxidation and can influence protein activity. However, the evolution of the plastid glutathione-dependent redox network in land plants and the conservation of cysteine residues undergoing S-glutathionylation is largely unclear.Results: We analysed the genomes of nine representative model species from streptophyte algae to angiosperms and find that the components of the plastid glutathione-dependent redox network are largely conserved, except for lambda- and the closely related iota-glutathione S-transferases. Screening the literature for target thiols of S-glutathionylation, we find that 151 plastid proteins have been identified as glutathionylation targets, while the exact cysteine residue is only known for 17% (26 proteins), with one or multiple sites per protein, resulting in 37 known S-glutathionylation sites for plastids. However, 38% (14) of the known sites were completely conserved in model species from green algae to flowering plants, with 22% (8) on non-catalytic cysteines. Variable conservation of the remaining sites indicates independent gains and losses of cysteines at the same position during land plant evolution.Conclusions: We conclude that the glutathione dependent redox network in plastids is highly conserved in streptophytes with some variability in scavenging and damage repair enzymes. Our analysis of cysteine conservation suggests that S-glutathionylation in plastids plays an important and yet under-investigated role in redox regulation and stress response.
Data Analysis on Medical Service Utilization and Out-of-pocket Spending among Near-poor National Health Insurance Members in South Korea
Authors: park sooyeol 
Published: December 2020

Abstract
Background: The near poor, a low income population which is excluded from the Republic of Korea's Medical Aid (MA) program, experiences insufficient use of medical services and high out-of-pocket (OOP) spending due to insufficient coverage by the country's National Health Insurance (NHI). This study aims to examine medical utilization, OOP spending, and occurrence of catastrophic health expenditures (CHE) among the near poor compared to MA beneficiaries and other NHI members.Methods: A cross-sectional study was conducted drawing upon a nationally representative dataset based on the 2018 Korea Welfare Panel Study (KOWEPS). We classified people into MA beneficiaries, the near-poor population below 50% of the median income threshold, and other NHI members above the 50% median income threshold. Using propensity score matching between MA beneficiaries and the near poor and between the near-poor group and the group of those above the poverty line, this study examined medical utilization, OOP spending, and the occurrence of CHE among the study groups. Results: The findings suggest that MA beneficiaries make greater use of outpatient services compared to the near poor, but other uses of medical services were not significantly different among the study groups. However, OOP spending and occurrence of CHE were significantly higher in the near-poor group compared to the other two groups. Conclusion: We found that the near-poor group was the most vulnerable group in these terms among the Korean population. Health policy needs to take into account the vulnerability of the near-poor population.