bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational gait analysis
Authors: Donnan Leo 
Published: December 2024

Purpose of review
The review is aimed at practising paediatricians who want to improve their clinical skills in observational gait analysis. Many paediatric complaints relate to problems of walking or limb alignment, and only a small proportion of these are pathological. With a deeper understanding of normal gait and a framework to conduct an observational analysis, the clinician can feel more confident diagnosing and recognizing those walking patterns that need further investigation.

Recent findings
Advances in instrumented gait analysis over the last two decades have provided deeper insights into the mechanisms of walking, how to interpret gait deviations, and their effect on locomotion. This has helped improve the quality of observational gait analysis and, in many ways, defined its limitations.

Summary
This review explains the components of normal gait and provides a structured approach to observational gait analysis. It also discusses the cause of limps and expands upon the importance of understanding rotational deformities. Finally, some tools to enhance the observational analysis are presented.
Persistent lichen planus pigmentosus inversus in a 45-year-old woman: a decade-long clinical journey and therapeutic challenges in an uncommon dermatological variant
Authors: Alsoleman Moath Moeen , Alkheder Ahmad , Fathallah Ibrahim , Alsodi Zeina 
Published: December 2024

Introduction and significance:
Lichen planus pigmentosus inversus (LPPI), a rare variant primarily affecting non-sun-exposed areas in Caucasians, is resistant to standard treatments. This case highlights its clinical challenges and persistence.

Case presentation:
A 45-year-old woman with a decade-long history of light to dark brown macules and patches, initially in the axillary and inguinal regions, experienced progressive spread to her forearms, upper arms, and inframammary areas. Despite normal lab results and no significant family history or trauma, histopathology confirmed LPPI. Treatment with topical steroids, pimecrolimus, tretinoin, and oral prednisolone led to partial resolution, though irritation from pimecrolimus required reduced application.

Clinical discussion:
LPPI is a chronic inflammatory condition, first described by Pock et al. in 2001, affecting primarily intertriginous areas in lighter-skinned individuals. Characterized by hyperpigmented macules with minimal pruritus, LPPI often involves the axillae, groin, and inframammary regions. Histopathological features include atrophic epidermis, pigmentary incontinence, and a lichenoid inflammatory infiltrate. Differential diagnosis includes ashy dermatosis and post-inflammatory hyperpigmentation. LPPI’s clinical course is variable, with treatments like tacrolimus and corticosteroids yielding inconsistent results.

Conclusion:
This case report documents a rare instance of pigmented inverse lichen planus in a 45-year-old woman, highlighting its chronic nature, treatment resistance, and ongoing challenges in managing pigmentation.
The Use of Cannabis Products for the Management of Pain Associated With Gynecologic Conditions
Authors:   The American College of Obstetricians and Gynecologists’ Committee on Clinical Consensus – Gynecology in collaboration, Oelschlager Anne-Marie , Gecsi Kimberly , Rodriguez Melissa 
Published: December 2024

(Abstracted from Obstet Gynecol 2024;144:e24–e34
The public perception, use, and legal status of cannabis have shifted dramatically over the last few years, with notable gain in acceptance for medical and nonmedical use. Federal law currently classifies cannabis as a Schedule I substance, and federally, it is outlawed, but individual states have been legalizing cannabis for several decades.
Isolated Sagittal Craniosynostosis and Open or Endoscopic Cranial Vault Remodeling: An Evaluation of Developmental Outcomes
Authors: Paliwoda Ethan D. , Horne Mason J. , Patel Ishan , Gajjar Avi A. , Rudolph Christina , Adamo Matthew A. , Bray Stephanie M.C. 
Published: December 2024

Background:
Craniosynostosis, a condition involving the premature fusion of cranial sutures, can impair brain development and﻿ potentially lead to developmental delays. This study compares open cranial vault remodeling versus endoscopic strip craniectomy treatment for isolated sagittal craniosynostosis, primarily focusing on development outcomes.

Methods:
A retrospective cohort study was conducted at a tertiary pediatric surgery center, involving all 45 patients treated surgically ﻿for isolated sagittal craniosynostosis from 2013 to 2024. Patients were categorized into 2 groups based on surgical intervention: open cranial vault remodeling (n=17) and endoscopic strip craniectomy (n=28). Data collected included patient demographics, intraoperative specifics, and postoperative outcomes. Developmental outcomes were assessed using postoperative progress notes.

Results:
Of the 45 patients, those undergoing open surgery were older (10.7 mo and 9.4 kg versus 3.3 mo and 6.4 kg, P<0.001) and experienced higher use of intraoperative drains (65% versus 0%, P<0.001), more prolonged ﻿procedures (189 versus 58 min, P<0.001), more significant ﻿blood loss (102 versus 62 mL, P=0.009), longer stays (3.3 versus 2.6 d, P=0.011), and higher opioid prescription rates (82% versus 43%, P=0.013﻿) compared to ﻿the endoscopic group. Within 12 months postoperatively, social delays were more common in the open group (19 versus 0%, P=0.049), and, postoperatively in general, cognitive delays were more common in the open group (31% versus 4%, P=0.023) when compared to ﻿the endoscopic group.

Conclusions:
Endoscopic cranial vault remodeling produces preferentially better hemodynamic, postoperative, and hospital stay outcomes. Although inferences into long-term developmental delay outcomes were limited due to sample size, a preferential benefit toward endoscopic intervention may exist.
Deceased Donor Renal Allograft Utility in Adult Single and Multi-organ Transplantation in the United States
Authors: Altshuler Peter J. , Bodzin Adam S. , Andreoni Kenneth A. , Singh Pooja , Yadav Anju , Glorioso Jaime M. , Shah Ashesh P. , Ramirez Carlo Gerado B. , Maley Warren R. , Frank Adam M. 
Published: December 2024

Background.
Deceased donor multiorgan transplants utilizing kidneys (MOTs) can improve outcomes for multiorgan recipients but reduces kidneys for chronic renal failure patients.

Methods.
We reviewed the Organ Procurement and Transplantation Network database from 2015 through 2019, for adult deceased donor kidney transplants. Recipients were classified as kidney transplant alone (KTA) (n = 62,252) or MOTs pancreas-kidney, simultaneous pancreas-kidney (n = 3,976), liver-kidney, simultaneous liver-kidney (n = 3,212), heart-kidney, simultaneous heart-kidney (n = 808), and “other”-kidney, simultaneous “other” kidney (n = 73).

Results.
Liver, heart, and lung-alone transplants were at least 7 times more frequent than their MOT correlate, whereas the inverse was true with pancreas transplantation with SPKs being by far the most common pancreas transplant type. On average, KTA recipients waited between 2.8 and 21.4 times longer than MOTs, with SPKs waiting the longest of the MOT types. Predialysis initiation transplants were less frequent in KTAs compared with MOTs. Use of high-quality grafts according to Kidney Donor Profile Index < 35% was frequent among MOTs, but uncommon in KTAs who had an Estimated Post Transplant Survival score (EPTS) of >20%. For recipients older than 65, SPKs and SOKs were rare, but SLKs and SHKs had a higher fraction of recipients than KTAs and were much more likely to use a Kidney Donor Profile Index <35% kidney. SPKs and KTAs with an EPTS ≤20% had the best kidney graft survival. KTAs with an EPTS ≤80% had better kidney graft survival than SLKs, SHKs, and SOKs.

Conclusions.
This study highlights disparities in access to deceased donor kidneys for kidney-alone candidates versus MOTs and suggests opportunities to improve allocation.
Decoding the effect of temperatures on conformational stability and order of ligand unbound thermo sensing adenine riboswitch using molecular dynamics simulation
Authors: Das Soumi 
Published: December 2024

AbstractThe structure-function relationship of the riboswitch is governed mainly by two factors, ligand binding and temperature. Most of the experimental studies shed light on structural dynamics and gene regulation function of Adenine riboswitch from the aspect of ligand instead of temperature. Two unliganded Adenine riboswitch conformations (apoA and apoB) from the thermophileVibrio vulnificusdraw particular attention to the Biophysics research community due to their diverse and polymorphic structures. Ligand-free apoB Adenine riboswitch conformation is not able to interact with the ligand whereas ligand-free apoA Adenine riboswitch conformation adopts ligand-receptive form. The interconversion between apoA and apoB conformation is temperature-dependent and thermodynamically controlled. Therefore Adenine riboswitch is called a temperature sensing RNA. The molecular mechanism underlying the thermosensitivity of ligand free Adenine riboswitch is not well known. Hence it is essential to explore temperature-induced conformational dynamics of unliganded Adenine riboswitch. In this research work I make an attempt to examine conformational stability and order of apoA with respect to apoB Adenine riboswitch aptamer using conformational thermodynamics derived from all-atom molecular dynamics trajectories in the temperature range 283K-400K. The changes in conformational free energy and entropy of conformational degrees of freedom like pseudo-torsion angle ⍰ and θ are computed. RMSD, RMSF, RG, principal component analysis, hydrogen bonding interaction, and conformational thermodynamics data demonstrate that conformational stability and order of apoA with respect to apoB adenine riboswitch conformation is significant at 293K and 303K. The temperatures corresponding to the conformational order and stability of apoA adenine riboswitch with respect to apoB adenine riboswitch whole aptamer are shown in descending order 293K∼303K> 313K∼283K>373K>323K. The topological and conformational changes related to hydrogen bonding reorganization occur mostly at temperature 323K and 400K. Ligand unbound adenine riboswitch is sensitive to heat and may be inactivated at temperatures 323K and 400K.HighlightsMolecular Dynamics Simulation of ligand unbound two different conformations of adenine riboswitch with the same sequence at different temperatures are performed.At low temperatures (293K and 303K) the conformational stability of apoA is more pronounced compared to apoB adenine riboswitch.Thermal stability of apoA compared to apoB adenine riboswitch is the least at 323K temperature.At higher temperature (373K) and lower temperature (283K) apoA adenine riboswitch exerts moderate conformational stability.The nucleotides from stem2 and junction (J1/2, J2/3) regions of adenine riboswitch contribute the most to the conformational stability and order.
An eye-tracking study on the impact of incorporating rhetorical figures in English-Chinese advertisement translation
Authors: Cui Ying , Liu Xiao 
Published: December 2024

PurposeRhetorical figures are frequently used in English-Chinese advertisement translation, but their impact on consumers is an under-studied issue. This research aims to explore Chinese consumers’ perception of two categories of rhetorical figures in bilingual advertising, namely schemes and tropes, via an eye-tracking experiment.Design/methodology/approachIt takes rhyme and antithesis as representative examples of schemes and takes metaphor as an example of tropes. Eighty-six native Chinese speakers with satisfactory English proficiency participated in the experiment. Thirty English slogans without rhetorical figures were selected for the experiment. Two parallel Chinese versions were prepared, one with rhetorical figures and the other without. Participants were randomly assigned to read the English version and one Chinese version.FindingsData analyses show that the translations with rhetorical figures generally involve higher fixation duration or count, smaller saccade amplitude and higher subjective ratings. In particular, the impact of metaphor is more prominent than that of rhymes and antitheses. Still, English texts receive higher ratings than Chinese translations except for cases where metaphors are used in translations.Practical implicationsThe results suggest that incorporating rhetorical figures particularly tropes into Chinese translations is effective in increasing Chinese consumers’ attention and processing depth and to present English advertisements together with Chinese translations can be helpful for affecting their attitude.Originality/valueIt applies the eye-tracking approach to explore Chinese consumers’ perception of rhetorical figures. It provides empirical evidence for the effectiveness of tropes.
Scrutinizing informal female entrepreneurship: a systematic review and research agenda
Authors: Martins Izaias , Nunez Maria Antonia , Perez Juan P. , Villanueva Eduart 
Published: December 2024

PurposeInformal female entrepreneurship (IFE) represents a significant yet understudied dimension of economic activity globally. This research aims to conduct a systematic literature review (SLR) on IFE.Design/methodology/approachThis SLR delves into the intricate landscape of IFE, examining scholarly contributions sourced from the Web of Science Social Sciences Citation Index database.FindingsBy synthesizing existing literature, this review sheds light on the multifaceted dynamics surrounding IFE, encompassing factors such as socioeconomic contexts, cultural influences and institutional frameworks. Moreover, this study underscores the importance of addressing the unique challenges and opportunities faced by women engaged in informal entrepreneurial activities. In doing so, it not only enriches our understanding of female entrepreneurship but also underscores the need for tailored policies and interventions to support women in these endeavours.Originality/valueThis inquiry’s relevance stems from the pivotal role that women play in informal economies, which often remain obscured by traditional economic metrics. This review contributes to the scholarly discourse by proposing a research agenda to advance knowledge and inform future investigations into this critical domain.
Evaluating the effect of making the indication field compulsory in electronic prescriptions: A pre‐post study in a hospital prescribing system
Authors: Pairman Lorna , Chin Paul , Doogue Matthew 
Published: December 2024

AbstractAimsRecording the indication for a medicine in the prescription supports communication. In May 2023, our district hospitals made the free‐text indication field in prescriptions compulsory for all medicines in the inpatient prescribing system. This study aimed to evaluate the effect of introducing a compulsory indication field in an inpatient prescribing system.MethodsText in the indication field was manually classified as an indication, ‘other text’, ‘rubbish text’, ‘to be determined’ and ‘blank’. Prescribing data were extracted from the district data warehouse. The change in proportion of prescriptions with an indication was compared for 8 weeks after introduction of a compulsory indication field to an equivalent 8 weeks in 2022. Secondary outcomes included medication cessation and indication recording before discharge.ResultsWe analysed 81 634 prescriptions before and 82 726 after indications were made compulsory. The proportion of prescriptions with an indication increased from 29.2% to 75.6%. ‘Rubbish text’ increased from 0% to 2.3%, ‘other text’ from 2.5% to 14.7%, and ‘to be determined’ from 0.0% to 6.6%. Of 5557 prescriptions with ‘to be determined’ initially, 18.1% were ceased and 2.7% had an indication before discharge.ConclusionsAfter making the prescription indication field compulsory, the proportion of medicines with an indication increased from 29% to 76%, with only a small increase in ‘rubbish text’. Following the system change, the quality of information recording improved but there was no change in medicine use. Compulsory fields should be combined with improvements in other components of care to improve medicine use.
USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53
Authors: Zhu Yuqi , Chen Zixiang , Niu Kaifeng , Li Mengge , Deng Yuchun , Zhang Ji , Wei Di , Wang Jiaqi , Zhao YongLiang 
Published: December 2024

ABSTRACTThe de‐ubiquitinase USP33 has been shown to possess either tumour‐promoting or inhibitory effect on human cancer cells. However, all these findings are mainly based on in vitro cell culture models, and the in vivo evidence, which is more plausible to digest the functional role of USP33 in carcinogenic process, is still lacking. Here, we demonstrate that USP33 modulates DNA damage responses including cell cycle arrest and apoptosis induction through associating with p53. It directly interacts with p53 to mediate its de‐ubiquitination and further stabilisation under DNA damage condition. Depletion of USP33 induces an enhanced level of p53 ubiquitination, which de‐stabilises p53 protein leading to impaired DNA damage responses. Furthermore, USP33 silencing shows either promoted or inhibited effect on cell proliferation in human cancer cells with p53 WT and mutant background, respectively. Consistently, mice with hepatocyte‐specific USP33 knockout are more sensitive to nitrosodiethylamine (DEN)‐induced hepatocarcinogenesis compared to wild type mice. Thus, our in vitro and in vivo evidences illustrate that USP33 possesses anti‐tumour activity via regulating p53 stability and activity.
Sustainable‐collaborative scheduling of multi‐stage hybrid flowshop with heterogeneous production and transportation using a green scheduling strategy‐based NSGA‐II‐MFO algorithm
Authors: Duan Jianguo , Chen Fangrong , Feng Mengyu , Yang Mengpei , Du Yulin 
Published: December 2024

AbstractThe manufacturing of large metallic components typically involves cutting, welding, assembly, and machining, which consume a significant number of resources and result in substantial carbon emissions. In addition, there is a wide variety of intermediate parts in the production process, which is prone to the problem of kitting and long waiting times. The traditional single‐stage scheduling made it difficult to achieve overall production optimization. Furthermore, due to the large size of the workpiece, transportation equipment also consumes a significant amount of energy and generates carbon emissions during transportation. In heterogeneous hybrid flowshop, there is significant potential for optimizing the collaborative scheduling between processing machines and transportation equipment as well as between different transportation devices. This study presents a green scheduling model that considers the optimization of both the maximum makespan and the carbon emissions generated by the processing machines and transport equipment. The model also takes into account the idle state of the processing machines to further reduce carbon emissions. A green scheduling strategy is proposed to solve this model, along with an enhanced NSGA‐III (Non‐Dominated Sorting Genetic Algorithm III) that integrates the Moth‐Flame Optimization algorithm. Additionally, 15 arithmetic examples are provided to illustrate the manufacturing process of large metallic components of different scales. The effectiveness of the proposed algorithm is demonstrated through comparisons with commonly used intelligent optimization algorithms and non‐collaborative scheduling. The findings highlight the efficacy of collaborative scheduling in the heterogeneous multi‐stage hybrid flowshop for large metallic components, resulting in reduced manufacturing time and carbon emissions.
Barriers and Facilitators to Age‐Friendly Health Care: A Scoping Review
Authors: Xu Danni , Xu Suyi , Zheng Kexin , Zhang Meiyun 
Published: December 2024

ABSTRACTAimsAs the global population ages, older adults are increasingly experiencing more complex health problems, resulting in an increase in the prevalence of prolonged hospitalisation. This study aimed to explore the barriers and facilitators to age‐friendly health care.DesignScoping review.Data SourcesA systematic search was performed from 2004 to 2024 in the following eight electronic databases: PubMed, Cochrane Library, Web of Science, EBSCOhost, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, China Science and Technology Journal Database and WanFang. A manual search was conducted through the references of the included papers and related publications.Review MethodsThis review utilised the scoping review methodology framework proposed by Arksey and O'Malley. Studies were screened and extracted independently by two reviewers using a standardised form. Thematic synthesis was used to summarise data. The PRISMA‐ScR Checklist was also used.ResultsThirty‐seven studies were included. The following six themes were identified: (1) communication and services; (2) facilities and environment; (3) leadership and policy; (4) information management and investment; (5) education and training and (6) multidisciplinary resources.ConclusionSeveral barriers and facilitators to age‐friendly health care have been reported. Communication and service issues are critical to age‐friendly care both in developed and developing countries. Understanding modifiable barriers and facilitators is essential to addressing these factors and promoting evidence‐based care for older individuals.ImpactWith the rapid growth of ageing populations worldwide, hospitals need to adapt to ensure age‐friendly health care for older patients, and this review provides insights on barriers and facilitators to age‐friendly health care. To this end, the review is designed to stimulate global discussions among hospital leaders, clinicians and staff; policymakers and researchers to improve care for patients as they age.Patient or Public ContributionNo patient or public contribution.