bluuebunny/crossref_metadata_2025_split huggingface dataset:
The performance effects of management control instruments in different stages of new product development
Authors: Munck Jan Christoph , Tkotz Alexander , Heidenreich Sven , Wald Andreas 
Published: June 2020

PurposeThe study builds on existing research in management control (MC) and innovation management. The purpose of this study is to identify patterns in the application of MC instruments which contribute to successful innovation. The application of MC instruments can reduce potential risks and make the new product development (NPD) process more transparent and efficient.Design/methodology/approachThe authors use dyadic data to determine the effect of 58 MC instruments on NPD process stage-specific performance and subsequent innovation and firm success. To provide empirical evidence of each MC instrument’s effectiveness, three importance-performance matrix analyses were conducted that assess the impact of each MC instrument.FindingsThe authors identify patterns in the application of MC instruments which contribute to successful innovation activities and the authors determine the impact of MC instruments on NPD performance, innovation performance and firm performance in different stages of the NPD process.Practical implicationsThe authors provide knowledge that can be used by managers to review their actual application of MC in the NPD process and to select their instrument set.Originality/valueThe authors contribute to the MC literature by examining data from a cross-industry study on the effects of MC instruments during the NPD process. The authors include a comprehensive set of MC instruments and show how their effect changes between the different stages of the NPD process.
An analysis of sustainability and channel coordination in a three-echelon supply chain
Authors: Huang Ruting , Yao Xin 
Published: June 2020

PurposeThe purpose of this paper is to investigate the decision behaviors and channel coordination of a sustainable three-echelon supply chain with retailer-led game setting.Design/methodology/approachThe authors develop game-theoretic models to examine the decision behaviors of channel members in a three-echelon supply chain consisting of one supplier, one distributor and one dominated retailer. The authors first formulate two models for centralized decision and decentralized decision. And then this paper proposes sub-supply chain coordination and a two-tariff contract to coordinate the full supply chain. Finally, some management insights are obtained with a case study.FindingsThe authors find that when faced with environmentally conscious consumers, the channel members can benefit from higher greening level; however, higher cost of green technologies would have negative impacts on manufacturer's effort. The analysis also shows that cooperation among players can improve the supply chain performance and help with environmental improvement.Research limitations/implicationsThe findings provide important managerial insights for the three-echelon supply chain to achieve sustainable goals where the retailer bears the environmental responsibility. However, this paper also has some limitations with assuming risk-neutral channel members and symmetric information.Originality/valueThe findings of the study contribute to coordination and collaboration in sustainability of supply chains. The results provide important managerial insights for the three-echelon supply chain to achieve sustainable goals.
Insights from corporate social innovation: a research agenda
Authors: Tabares Sabrina 
Published: June 2020

PurposeThe purpose of this study is to analyse the contributions, major discussions and trends in the literature driving the research agenda in corporate social innovation (CSI). This is done through a systematic review on CSI publications in an open time span. Salient themes and emerging research topics in this literature, as well as research questions and limitations, are identified, culminating in a discussion of what is next for CSI research.Design/methodology/approachA systematic review was undertaken from academic and grey literature. Results were analysed following a bibliometric and interpretative content analysis.FindingsThe study provides novel insights on CSI research by drawing attention to discussions around the consensus on a definition of CSI, its disciplinary origins and the denominations referring to this field. Although CSI struggles to gain independence as a research field, the evidence shows that CSI is a cross-disciplinary concept nourished by multiple disciplines.Research limitations/implicationsAnalysis in this paper has implications for research by highlighting the state of scholarship on CSI. Given the use of multiple denominations of CSI, several studies using low diffused denominations could be discarded.Originality/valueThis research contributes to the body of knowledge in the field of CSI by bringing clarity to former discussions and by suggesting how the field can move forward to a more advanced and mature state in research.
Identification of consumption patterns: an empirical study in millennials
Authors: Escandon-Barbosa Diana , Hurtado-Ayala Andrea , Rialp-Criado Josep , Salas-Paramo Jairo A. 
Published: June 2020

Purpose
Societal changes and technological development have brought about drastic lifestyle change in the past decades. This drastic change is evident when comparing the lifestyle and general characteristics of generations who have been born immersed in this technological context to those of other generations. The objective of this paper is to analyze brand image (BI) as determinant of brand attitude (AB), and the moderating effect of brand equity (BE), in the use of online information among millennial shoppers from Colombia. In general, the purpose of this paper is to contribute to existing literature related to the importance of generational membership in classifying individuals regarding brand perception (BI, AB and BE) and association with the use of shopping channels between different generations.

Design/methodology/approach
A hierarchical regression model is estimated with a sample of university students in Colombia who are considered potential coffee consumers, and who were classified as millennials based on their age.

Findings
The results support that BE effect has a greater impact on AB when consumers have a good BI. Millennials also use more online communication sources to create brand perceptions.

Originality/value
Nevertheless, few studies have concurrently analyzed the characteristics of brand building and types of sources of information (online vs offline). This paper attempts to analyze the behavior of millennial consumers and the use of information channels online vs offline to manage brand and analyze BI, AB and BE.
The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin
Authors: Zenklusen Isabelle , Muehlan Clemens , Ulc Ivan , Liška Jiří , Dingemanse Jasper 
Published: June 2020

AbstractDaridorexant is a dual orexin receptor antagonist in clinical development for the treatment of insomnia. Breast‐cancer resistant protein (BCRP) is an efflux pump expressed in intestinal epithelium and hepatocytes, contributing to the absorption, distribution, and elimination of drugs and endogenous compounds. In vitro, daridorexant inhibits BCRP with an IC50 of 3.0 μmol/L. The BCRP substrate rosuvastatin is a cholesterol‐lowering drug, recommended for clinical drug–drug interaction (DDI) studies. In order to exclude an inhibitory effect of daridorexant on BCRP, this single‐centre, open‐label, two‐treatment Phase 1 study investigated the effect of daridorexant at steady state on the pharmacokinetics (PK) of single‐dose rosuvastatin in 20 healthy male subjects. In addition, safety and tolerability were assessed. A single oral dose of 10 mg rosuvastatin on Day 1 was followed by 96 hours observation. Thereafter, 25 mg daridorexant was administered once daily (o.d.) on Days 5–8 and in combination with 10 mg rosuvastatin on Day 8. On Days 9–12, subjects received 25 mg daridorexant alone. PK sampling was performed up to 120 hours after treatment administration. The results showed that concomitant administration of 25 mg daridorexant o.d. at steady state did not affect the exposure parameters of rosuvastatin in a relevant way, as indicated by the ratios of geometric means (GMRs) ([rosuvastatin + daridorexant]/[rosuvastatin alone]) of 0.93 for both Cmax and AUC0‐∞. Administration of a single dose of 10 mg rosuvastatin, multiple doses of 25 mg daridorexant alone or in combination were well tolerated. Taken together, daridorexant and BCRP substrates can be safely co‐administered.
English, Welsh and Irish Scholars in the New Universities of the Continent in the Later Middle Ages
Authors: EMLYN RHUN 
Published: June 2020

AbstractWhen considering the experiences of medieval English, Welsh or Irish scholars in continental Europe historians have tended to focus on the older, more prestigious universities such as Paris or the numerous Italian centres of learning. There have been very few attempts to look systematically at the younger universities that were established in parts of northern Europe in the later Middle Ages, based on the assumption that very few students from England, Wales or Ireland studied at these institutions. By researching the matriculation registers of the universities of Cologne and Leuven, and using these universities as case studies, this article shows that a significant and increasing number of students were making their way to the new universities of the continent during the fifteenth century. These included a number of important figures in the political and ecclesiastical life of later medieval England. The article argues that these universities in fact played an important part in the academic life of England, and to a lesser degree Wales and Ireland. They enhanced the prospects of ambitious clerics, educated prominent figures in royal government, provided stepping stones to Italy, encouraged the pre‐existing political and economic links between England and the Low Countries and contributed towards the growth of humanism in England. By studying Cologne and Leuven we are given an insight into the process of migrating between universities, the effect of political and economic connections on university attendance and the role of universities in fostering more harmonious international relations.
From Territorial Cohesion to Regional Spatial Justice: The Well‐Being of Future Generations Act in Wales
Authors: Jones Rhys , Goodwin‐Hawkins Bryonny , Woods Michael 
Published: June 2020

AbstractThe European Union's flagship Cohesion Policy faces evidence of dubious economic effectiveness and growing political and philosophical critiques of the very ideals of furthering European integration. This article examines ambitions for territorial cohesion as they have been operationalized through regional development in Wales. We argue that a potential alternative to the failed realization of territorial cohesion lies in the principles of spatial justice. While territorial cohesion has typically emphasized the redistribution of funds to ‘lagging’ regions, spatial justice, as we define it, is premised upon enabling regions to assert their own capacity to act and pursue positive visions of regional futures, consider the implications of space and scale for the achievement of justice, and define well‐being, development and the ‘good life’ in ways that reflect regional priorities. We examine three ways in which recent political discourses and policy mechanisms in Wales resonate with these ideals. We focus on attempts to envision a progressive Welsh future, develop alternative spaces and scales of governance, and redefine and pluralize understandings of progress and well‐being. The article concludes by reflecting on the practical and conceptual implications of rescaling spatial justice to regional contexts.
The Application of Photogrammetry in the Autopsy Room: A Basic, Practical Workflow*
Authors: Gitto Lorenzo , Donato Laura , Di Luca Alessandro , Bryant Stephanie M. , Serinelli Serenella 
Published: June 2020

AbstractPhotogrammetry is a technique that uses two‐dimensional photographs taken from different angles and positions to determine three‐dimensional coordinates and distances. Becoming familiar with the photography technique for photogrammetry purposes is the first step to obtaining high‐quality results. Ten human cadavers were studied to develop this protocol. Appropriate equipment settings, measurements, and suitable ambient conditions were determined. Finally, the protocol was tested on one cadaver wherein a full postmortem examination was conducted, allowing accurate 3D modeling and measurements of the human body. This straightforward, step‐by‐step workflow will help users become familiar with this technique. A thorough description of the necessary steps is reported, including equipment, environment requirements, body placement, how to take photographs, and the minimum suggested number of photographs. Numerous graphics show the protocol's main steps to help users understand and reproduce the entire process. Photogrammetry allows the permanent recording and storage of photographic evidence of conditions that existed at the time of autopsy and accurate measurements of the body. The 3D model can have a powerful effect in court, where the findings can be accurately depicted without elicitation of strong emotion that may influence the judge or jurors. The primary disadvantage of photogrammetry for forensic pathology is its time‐consuming nature. However, the widespread use of the photogrammetry technique in postmortem rooms would allow in‐depth testing to detect and fix potential pitfalls, making this technique more reproducible and verifiable, increasing its admissibility in courts.
High‐efficiency transformation of archaea by direct PCR products with its application to directed evolution of a thermostable enzyme
Authors: Song Yunhong , Zhu Zhiguang , Zhou Wei , Zhang Yi‐Heng P. Job 
Published: June 2020

SummaryHyperthermophilic archaea with unique biochemical and physiological characteristics are important organisms for fundamental research of life science and have great potential for biotechnological applications. However, low transformation efficiency of foreign DNA molecules impedes developments in genetic modification tools and industrial applications. In this study, we applied prolonged overlap extension PCR (POE‐PCR) to generate multimeric DNA molecules and then transformed them into two hyperthermophilic archaea, Thermococcus kodakarensis KOD1 and Pyrococcus yayanosii A1. This study was the first example to demonstrate the enhanced transformation efficiencies of POE‐PCR products by a factor of approximately 100 for T. kodakarensis KOD1 and 8 for P. yayanosii A1, respectively, relative to circular shuttle plasmids. Furthermore, directed evolution of a modestly thermophilic enzyme, Methanothermococcus okinawensis 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGR), was conducted to obtain more stable ones due to high transformation efficiency of T. kodakarensis (i.e. ~3 × 104 CFU per μg DNA). T. kodakarensis harbouring the most thermostable MoHMGR mutant can grow in the presence of a thermostable antibiotic simvastatin at 85°C and even higher temperatures. This high transformation efficiency technique could not only help develop more hyperthermophilic enzyme mutants via directed evolution but also simplify genetical modification of archaea, which could be novel hosts for industrial biotechnology.
Al‐Ghoryeen: An Early Bronze Age settlement in central Oman peninsula
Authors: Al‐Jahwari Nasser S. , Douglas Khaled A. , Hesein Mohamad A. 
Published: June 2020

AbstractAl‐Ghoryeen, located 95 km southwest of Muscat, is a unique settlement dating to the Umm an‐Nar period and is built upon a Late Hafit period settlement. It was found in 2004 and excavation began in 2018. Preliminary analysis of the results revealed two major occupation phases with an occupational gap in between. A change occurred between the earlier and later phases of the settlement system reflected mainly in the difference in building sizes and plan. We excavated either partially or completely a stone round tower and more than 10 domestic structures. The distribution of the architectural features including the round tower, domestic structures and burials showed some kind of organised settlement structure. The Hafit period settlement was tested in two trenches where 14C analysis dated the earliest occupation to the late Hafit period.
Etomidate Use Is Associated With Less Hypotension Than Ketamine for Emergency Department Sepsis Intubations: A NEAR Cohort Study
Authors: Mohr Nicholas M. , Pape Stephen G. , Runde Dan , Kaji Amy H. , Walls Ron M. , Brown Calvin A. 
Published: June 2020

AbstractObjectiveThe objectives of this study were 1) to describe the current use of etomidate and other induction agents in patients with sepsis and 2) to compare adverse events between etomidate and ketamine in sepsis.MethodsThis was an observational cohort study of the prospective National Emergency Airway Registry (NEAR) data set. Descriptive statistics were used to report the distribution of induction agents used in patients with sepsis. Adverse events were compared using bivariate analysis, and a sensitivity analysis was conducted using a propensity score–adjusted analysis of etomidate versus ketamine.ResultsA total of 531 patients were intubated for sepsis, and the majority (71%) were intubated with etomidate as the initial induction agent. Etomidate was less frequently used in sepsis patients than nonsepsis patients (71% vs. 85%, odds ratio [OR] = 0.4, 95% confidence interval [CI] = 0.4 to 0.5). Sepsis patients had a greater risk of adverse events, and vasopressor therapy was required for 25% of patients after intubation. Postprocedure hypotension was higher between those intubated for sepsis with ketamine versus etomidate (74% vs. 50%, OR = 2.9, 95% CI = 1.9 to 4.5). After confounding by indication in the propensity score–adjusted analysis was accounted for, ketamine was associated with more postprocedure hypotension (OR = 2.7, 95% CI = 1.1 to 6.7). No difference in emergency department deaths was observed.ConclusionsEtomidate is used less frequently in sepsis patients than nonsepsis patients, with ketamine being the most frequently used alternative. Ketamine was associated with more postprocedural hypotension than etomidate. Future clinical trials are needed to determine the optimal induction agent in patients with sepsis.
Surgery as a safe and effective treatment option for spheno‐orbital meningioma: a systematic review and meta‐analysis of surgical techniques and outcomes
Authors: Fisher Fleur L. , Zamanipoor Najafabadi Amir H. , Schoones Jan W. , Genders Stijn W. , van Furth Wouter R. 
Published: June 2020

AbstractPurposeThe effectiveness and safety of surgery for spheno‐orbital meningiomas remains subject of debate, as studies often describe different surgical approaches and reconstruction techniques with very heterogeneous outcomes. We aimed to systematically summarize and analyse the literature on spheno‐orbital meningiomas regarding presenting symptoms, surgical techniques, outcomes and complications.MethodsStudies were retrieved from eight databases. Original articles were included if in ≥5 patients presenting symptoms, surgical treatment and outcomes were described. Fixed‐ and random‐effects meta‐analysis was performed to estimate weighted percentages with 95%CIs of presenting symptoms, outcomes and complications.ResultsThirty‐eight articles were included describing 1486 patients. Proptosis was the most common presenting symptom (84%; 95%CI 76–91%), followed by unilateral visual acuity deficits (46%; 95%CI 40–51%) and visual field deficits (31%; 95%CI 20–43%). In 35/38 studies (92%), a pterional craniotomy was used. Decompression of the optic canal (82%) and the superior orbital fissure (66%) was most often performed, and usually dural (47%) and bony defects (76%) were reconstructed. In almost all patients, visual acuity (91%; 95%CI 86–96%), visual fields (87%; 95%CI 70–99%) and proptosis (96%; 95%CI 90–100%) improved. Furthermore, surgery showed improvement in 96% (95%CI 78–100%) for both diplopia and ophthalmoplegia. The most common surgical complications were hypesthesia (19%; 95%CI 10–30%), ptosis and diplopia (both 17%; 95%CI, respectively, 10–26% and 5–33%) and ophthalmoplegia (16%; 95%CI 10–24).ConclusionPatients with spheno‐orbital meningioma usually present with proptosis or unilateral decreased visual acuity. Surgery shows to be effective in improving visual acuity and visual field deficits with mostly minor and well‐tolerated complications.
Outcomes of pattern scanning laser trabeculoplasty and selective laser trabeculoplasty: Results from the lausanne laser trabeculoplasty registry
Authors: Elahi Sina , Rao Harsha L. , Paillard Archibald , Mansouri Kaweh 
Published: June 2020

AbstractPurposeTo compare the long‐term safety and efficacy of pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT).MethodsThis was a retrospective database analysis (Lausanne Laser Trabeculoplasty Registry) of patients having had laser trabeculoplasty (LT) prior to 2017 with a minimum follow‐up of 1 year. Inclusion criteria were age ≥40 years and diagnosis of ocular hypertension (OHT) and open‐angle glaucoma (OAG). Selective laser trabeculoplasty (SLT) eyes were matched to PSLT eyes according to baseline intraocular pressure (IOP), baseline number of ocular hypotensive medications (OHM) and glaucoma diagnosis. Success was defined as an IOP ≤ 20% from baseline or an IOP equal or lower than baseline accompanied by a reduction in OHM. Multivariate regression models were used to study associations between success and baseline clinical parameters.ResultsFrom 280 eyes in the database, 81 eyes had PSLT and were matched with 81 SLT eyes (162 patients). Mean age was 69.4 ± 12.1 years, and 56.2% were female. Mean IOP was 18.6 ± 5.3 and 18.2 ± 4.1 mmHg at baseline and 15.9 ± 3.0 and 16.0 ± 3.4 mmHg at 12 months and 15.2 ± 2.7 and 16.2 ± 3.4 mmHg at 24 months, for PSLT and SLT, respectively. 60.5% of PSLT and 65.4% of SLT eyes achieved treatment success (p = 0.20). Number of OHM was 1.0 ± 1.0 and 1.4 ± 1.2, respectively (p = 0.052). Baseline IOP (OR = 1.23, p < 0.01) and number of OHM (OR = 1.67, p < 0.01) were associated with success in both PSLT and SLT, while LT modality was not [OR = 0.81 (0.43–1.53), p = 0.52], and a diagnosis of primary OAG was negatively associated (OR = 0.42, p = 0.04).ConclusionOur study did not find any significant differences between PSLT and SLT in terms of safety and efficacy in patients with OHT and glaucoma. Baseline IOP was associated with higher success rates in both procedures. Additional studies are needed to evaluate the outcomes of PSLT in non‐Caucasian populations and the ability of repeat PSLT to achieve additional IOP reduction.