bluuebunny/crossref_metadata_2025_split huggingface dataset:
ssc-micorRNA-132 suppresses theClostridium perfringensbeta2 toxin induced inflammation and apoptosis of IPEC-J2 cells via targetingDACH1
Authors: Xie Kaihui , Yan Zunqiang , wang Wei , Luo Ruirui , Gao Xiaoli , Wang Pengfei , Yang Qiaoli , Huang Xiaoyu , Zhang Juanli , Yang Jiaojiao , Gun Shuangbao 
Published: November 2020

ABSTRACTClostridium perfringens(C. perfringens) beta2 (CPB2) is the main virulence factor secreted fromC. perfringenstype C, which caused diarrhea characterized by high mortality in pig, especially newborn piglets. Our previous research found that ssc-miR-132 displayed decreased expression in piglets diarrhea after infected withC. perfringenstype C compared with normal piglets. We speculated that ssc-miR-132 may play an important role in the diarrhea. However, the function of ssc-miR-132 in the diarrhea is limited. Thus, we overexpressed and knocked down ssc-miR-132 in intestinal porcine epithelial (IPEC-J2) cells, and then treated the cells with recombinant CPB2 (rCPB2) toxin (20 μg/mL). Our results showed that ssc-miR-132 was significantly decreased after treated with rCPB2 toxin. In addition, overexpression of ssc-miR-132 reduced the expression of lactate dehydrogenase (LDH) and tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) caused by rCPB2 toxin. The CCK8, Edu and TUNEL staining showed that overexpression of ssc-miR-132 weakened the inhibition of rCPB2 toxin on cell proliferation and reduced the promotion of cell apoptosis; while inhibition of ssc-miR-132 had opposite results. The dual luciferase experiment showed that dachshund family transcription factor 1 (DACH1) was the target gene of ssc-miR-132. SilencingDACH1was consistent with the results of overexpression of ssc-miR-132, and reversed the apoptosis and inflammation caused by rCPB2 toxin. Overexpression ofDACH1weakened the role of ssc-miR-132 in rCPB2 toxin -induced inflammation and apoptosis. In summary, ssc-miR-132 inhibited rCPB2 toxin-induced apoptosis and inflammation in IPEC-J2 cells by targetingDACH1.
Chromatin Fiber Folding Represses Transcription and Loop Extrusion in Quiescent Cells
Authors: Swygert Sarah G. , Lin Dejun , Portillo-Ledesma Stephanie , Lin Po-Yen , Hunt Dakota R. , Kao Cheng-Fu , Schlick Tamar , Noble William S. , Tsukiyama Toshio 
Published: November 2020

AbstractDetermining the conformation of chromatin in cells at the nucleosome level and its relationship to cellular processes has been a central challenge in biology. We show that in quiescent yeast, widespread transcriptional repression coincides with the local compaction of chromatin fibers into structures that are less condensed and more heteromorphic than canonical 30-nanometer forms. Acetylation or substitution of H4 tail residues decompacts fibers and leads to global transcriptional de-repression. Fiber decompaction also increases the rate of loop extrusion by condensin. These findings establish a role for H4 tail-dependent local chromatin fiber folding in regulating transcription and loop extrusion in cells. They also demonstrate the physiological relevance of canonical chromatin fiber folding mechanisms even in the absence of regular 30-nanometer structures.
Dissecting genomic determinants of positive selection with an evolution-guided regression model
Authors: Huang Yi-Fei 
Published: November 2020

AbstractIn evolutionary genomics, it is fundamentally important to understand how characteristics of genomic sequences, such as gene expression level, determine the rate of adaptive evolution. While numerous statistical methods, such as the McDonald-Kreitman test, are available to examine the association between genomic features and the rate of adaptation, we currently lack a statistical approach to disentangle the independent effect of a genomic feature from the effects of other correlated genomic features. To address this problem, I present a novel statistical model, the MK regression, which augments the McDonald-Kreitman test with a generalized linear model. Analogous to the classical multiple regression model, the MK regression can analyze multiple genomic features simultaneously to infer the independent effect of a genomic feature, holding constant all other genomic features. Using the MK regression, I identify numerous genomic features driving positive selection in chimpanzees. These features include well-known ones, such as local mutation rate, residue exposure level, tissue specificity, and immune genes, as well as new features not previously reported, such as gene expression level and metabolic genes. In particular, I show that highly expressed genes may have a higher adaptation rate than their weakly expressed counterparts, even though a higher expression level may impose stronger negative selection. Also, I show that metabolic genes may have a higher adaptation rate than their non-metabolic counterparts, possibly due to recent changes in diet in primate evolution. Overall, the MK regression is a powerful approach to elucidate the genomic basis of adaptation.
Knowledge map: a creative visual path to library guides and resources
Authors: Liu Weiling 
Published: November 2020

Purpose
This paper aims to indicate that library guides seem to be unfamiliar to most students or not easy to find or use. Some improvements have been made by embedding the guides in the learning management system or promoting the guides in formal library instructional classes. Are there other ways to promote or improve the use of library guides? The author proposes an exploratory visual solution to minimize this gap between library users and library guides.

Design/methodology/approach
Guided by the cognitive load theory, the proposed solution is a knowledge map created with Freeplane. The proposal is illustrated by comparing a sample knowledge map with its content source, a subject guide in LibGuides, via three browsing paths in locating a recommended database for a particular course on the sample subject guide website.

Findings
The knowledge map can display contents in different ways and provide a simple and visual layout with direct access to the library resources, which may help lessen users’ intrinsic cognitive load, minimize extraneous load or promote germane load. The map can also be beneficial to librarians for preparing teaching materials or guides management.

Practical implications
The proposed solution can be implemented with Freeplane based on existing library guides or created from scratch.

Originality/value
The proposed solution addresses a gap in the library field, where the use of knowledge maps for library services is overlooked.
Textbook ranking and an assessment method and system: a case study using surveying textbooks
Authors: Kuo Chien-Min , Chen Kuan-Yu , Lin Yi-Ching 
Published: November 2020

Purpose
Teachers, students, librarians, scholars and domain experts often spend a lot of time and effort to select good and suitable textbooks. This study aims to propose and construct a computer-aided bibliometric system to rate textbooks. Through the software system designed here, the quality of every textbook can be easily and quickly known. This system will benefit both scholars and librarians.

Design/methodology/approach
Four methods were used to evaluate textbooks in this study, including: questionnaire recommendation analysis, dissertation citation analysis, library circulation analysis and bibliography analysis. The system architecture includes three subsystems: the textbook indexing and searching subsystem, the statistics added-value analysis subsystem and the citation report inquiry subsystem. An example demonstrates the usability and validity of the proposed method and system. The example uses surveying textbooks. The following percentages were used in the correlation calculation: textbook citation percentage (TCP), textbook library circulation percentage (TLP) and textbook recommend percentage (TRP).

Findings
There are three textbook assessment methods applied in this study, including: dissertation citation, library circulation and questionnaire recommendation. Dissertation citations for textbooks have a high correlation value with library circulation. The frequency correlation calculation was 0.7, while the TCP, TLP and TRP correlation calculation was 0.84. Therefore, the dissertation citation method can be accepted to evaluate textbooks effectively.

Originality/value
To the best of the authors’ knowledge, this is the first work related to evaluating surveying textbooks using a computer-aided bibliometrics system that can deal with large amounts of data and generate results quickly. This can be applied to other fields as well.
Work–family policies and the transformation triangle: women, organizational culture and managerial strategy
Authors: Goñi Salomé , Corredor Pilar , León Consuelo 
Published: November 2020

PurposeThis research addresses how companies develop a process of transformation to a more family responsible behaviour and the role that women play in this process. This paper aims to propose a model in which a female workforce is seen as contributing to the development of the family responsible firm. The model includes two paths for transformation, the supportive work–family culture and the managerial strategy for work–family using a mediation model. The analysis was performed in a sample of 1,048 Spanish firms.Design/methodology/approachThe hypotheses are tested using Baron and Kenny’s (1986) mediated regression technique, the Sobel’s test (1982) and a bootstrap re-sampling with 5,000 and 10,000 iterations to determine the significance of the mediation.FindingsThe results confirm the impact of the proportion of women in the workforce on organizational culture and managerial strategy, factors that lead to a real increase in the accessibility of work–family policies. The mediation effect is total.Research limitations/implicationsLimitations stemming from the survey used and from the cross-sectional data.Practical implicationsThe role of women, the culture and managers in promoting work–family policies appears clear. The need for the active reinforcement of the supportive work–family culture in companies and managerial strategy, diffusion, planning and involvement are all key factors in the development of work–family policies.Social implicationsGovernments and society as a whole should urge firms to use all means at their disposal to guarantee the formal adoption of work–family policies.Originality/valueResearch that analyses the way in which work–family culture and the managerial strategy for work–family generate change does not usually incorporate the female component of the labour force as an explanatory element.
Bibliometric survey of IT Infrastructure Management to Avoid Failure Conditions
Authors: Bhanage Deepali Arun , Pawar Ambika Vishal 
Published: November 2020

Purpose
The purpose of this paper is to present the bibliometric study of articles IT Infrastructure Management to Avoid Failure Conditions. As in today’s era of IT Industries, IT infrastructure management plays a crucial role. As a result, substantial research is going on to improve the reliability and availability of assets in IT infrastructure.

Design/methodology/approach
The paper analyzes and focuses the results acquired from articles accessed from Scopus for the past 15 years by examining in terms of frequently used keywords, the amount of work done in different countries and year-wise progression of the research, prolific authors, article citation frequencies, etc. Tools such as Gephi, Word Cloud, BiblioShiny, GPS visualizer, etc. are used for bibliometric analysis.

Findings
The study comes out with maximum publications of IT infrastructure management from conferences and journals. Anomaly detection, log analysis and learning system are the most frequently used keywords in the publications. Significant research has been done in the USA, followed by China under the area of Computer Science with an increase in publication since 2018.

Originality/value
This paper provides an accurate idea about the amount of work done in different countries and year-wise progression of the research. This bibliometric analysis will be useful for beginners to conduct a literature survey using appropriate literature available on the Scopus database.
Business model innovation: a systematic review and future research directions
Authors: Bashir Makhmoor , Naqshbandi M. Muzamil , Farooq Rayees 
Published: November 2020

Purpose
The purpose of this paper is to systematically analyze the literature on business model innovation by identifying its triggers, enablers, barriers, dimensions, outcomes and highlight avenues for future research.

Design/methodology/approach
A systematic literature review of papers on business model innovation was conducted based on the recommendations of Tranfield et al. (2003) from 2000–2019. A total of 70 conceptual and empirical studies on business model innovation research spanning from 2000 to 2019 were analyzed based on different classification schemes.

Findings
The systematic review approach of this paper offers a new perspective in understanding business model innovation, bridges the gap in the extant literature by providing consolidation regarding the triggers, enablers, barriers, dimensions and outcomes of business model innovation and indicating avenues for future research.

Research limitations/implications
A review of literature on business model innovation carried out in this paper is expected to open up new horizons for future researchers to develop and empirically test frameworks related to business model innovation. The five themes identified to shed light on important aspects of business model innovation. These themes are expected to not only strengthen the theoretical foundations of business model innovation but also help practitioners develop and implement business model innovations in their organizations. In particular, the themes related to the enablers, barriers, triggers and outcomes of business model innovation can provide useful insights for practitioners.

Originality/value
This study is the first of its kind that has provided consolidation regarding the triggers, enablers, barriers, dimensions and outcomes of business model innovation.
Improving ICU transitional care by combining quality management and nursing science – two scientific fields meet in a systematic literature review
Authors: Sten Lilly-Mari , Ingelsson Pernilla , Bäckström Ingela , Häggström Marie 
Published: November 2020

Purpose
The purpose of this literature review was to explore to what extent quality management (QM) and nursing science offer complementary perspectives to provide better quality care, by looking at QM core concepts and tools.

Design/methodology/approach
A systematic literature review was conducted. Papers published in academic journals between January 2013 and December 2019 were included. A deductive content analysis was chosen using QM core values as an analytical framework.

Findings
The results showed that QM core values, methodologies and tools were found in the reviewed articles about intensive care unit (ICU) transitional care. The results indicated that core values in QM and the core competencies within nursing science in ICU transitional care are mutually dependent upon each other and exist as a whole. ICU transitional care is, however, a complex interpersonal process, characterized by differences in organizational cultures and core values and involving multidisciplinary teams that collaborate across hospital units. The QM core value that was least observed was committed leadership.

Research limitations/implications
Combining QM and nursing science can contribute to a deeper understanding of how to improve the ICU transitional care process by bringing complementary perspectives.

Practical implications
The included articles portray how QM is applied in ICU transitional care. Implications for future research focus on enhancing the understanding of how QM and nursing science can bring complementary perspectives in order to improve ICU transitional care and how QM values, methodologies and tools can be used in ICU transitional care. Committed leadership and team collaboration in ICU transitional care are areas that call for further research.

Originality/value
The findings contribute to the body of literature by providing important insights in terms of how QM core values, methodologies and tools are present in research about ICU transitional care and how the two research subjects, namely, QM and nursing science, bring complementary perspectives.
The recruitment, retention and development of an integrated urgent care telephone triage workforce: a small-scale study
Authors: Snell Laura , Grimwood Tom 
Published: November 2020

PurposeNHS 111 is a non-emergency telephone triage service that provides immediate access to urgent care 24 h a day. This study explored the recruitment, retention and development of one integrated urgent care (IUC) workforce in England, specifically the NHS 111 service and Clinical Hub.Design/methodology/approachAn online survey was distributed to the NHS 111 and Clinical Hub workforce. The data from 48 respondents were summarised and analysed thematically.FindingsThe survey respondents held a variety of clinical and non-clinical roles within NHS 111 and the Clinical Hub. The findings indicate that the IUC workforce is motivated to care for their patients and utilise a range of communication and cognitive skills to undertake their telephone triage roles. In total, 67% of respondents indicated that their work was stressful, particularly the volume and intensity of calls. Although the initial training prepared the majority of respondents for their current roles (73%), access to continuing professional development (CPD) varied across the workforce with only 40% being aware of the opportunities available. A total of 81% of respondents stated that their shifts were regularly understaffed which indicates that the retention of IUC staff is problematic; this can put additional pressure on the existing workforce, impact on staff morale and create logistical issues with managing annual leave entitlements or scheduling time for training.Originality/valueThis small-scale study highlights some of the complexities of telephone triage work and demonstrates the challenges for IUC service providers in retaining an appropriately skilled and motivated workforce.
2020 SEC risk alert provides guidance for private fund advisers
Authors: Breen Kenneth , Guberman Phara 
Published: November 2020

Purpose
To analyze the U.S. Securities and Exchange Commission (“SEC”) Office of Compliance Inspections and Examinations (“OCIE”) June 2020 Risk Alert, which identified three categories of deficiencies that the SEC regularly finds in its reviews of advisers to private funds, in order to understand its guidance and recommend best practices.

Design/methodology/approach
The study discusses the categories of deficiencies that the SEC regularly finds in its reviews of private fund advisers, current SEC enforcement trends, and recommendations for disclosures, internal controls, policies and procedures.

Findings
The SEC will expect private funds to identify and remedy regular deficiencies in three primary categories: gaps in client and investor disclosures regarding conflicts of interest; deficiencies in disclosures related to fees and expenses; and issues with policies and procedures regarding the treatment of material nonpublic information.

Practical implications
Private fund advisers should expect increased scrutiny during examinations on the identified deficiencies and use this opportunity to be proactive in addressing these issues.

Originality/value
Expert analysis and guidance from experienced securities enforcement attorneys.
EU whistleblowing rules to change in favor of whistleblowers
Authors: De Zwart Alja Poler 
Published: November 2020

Purpose
To describe the new EU Whistleblowing Directive and its implications.

Design/methodology/approach
Describes organizations to which the Directive applies, the scope of reportable whistleblowing concerns, whistleblowers’ reporting channels and mechanisms, whistleblower protections, how organizations should respond to whistleblower reports and how organizations should prepare for the new rules.

Findings
The new Directive will require Member States to create rules for organizations with more than 50 workers, will mandate such organizations to implement whistleblowing hotlines for reporting a broad range of EU law violations, and will contain minimum standards on how to respond to and handle any concerns raised by whistleblowers.

Practical implications
Organizations in the EU can and should start taking initial steps to prepare for the new rules as soon as possible. There will likely be some differences among whistleblower rules in individual EU Member States.

Originality/value
Practical guidance from experienced corporate, technology, media, telecommunications and compliance lawyer.
Liu v. S.E.C.: Supreme Court’s narrowing of SEC disgorgement raises questions for insider trading cases
Authors: Friedman Alan R. , James Dani R. , Naftalis Gary P. , Schoeman Paul H. , Mechanick Chase Henry 
Published: November 2020

Purpose
To analyze the U.S, Supreme Court’s decision in Liu v. S.E.C., 140 S. Ct. 1936 (2020) and its potential implications for insider trading cases.

Design/Methodology/Approach
Provides context on the history of disgorgement in SEC enforcement proceedings; discusses factual and procedural background underlying the Liu decision; summarizes the Court’s opinion and rationale, with a particular focus on the Court’s pronouncements regarding the permissible scope of SEC disgorgement as an equitable remedy; identifies and explores three possible issues in insider trading cases that may be affected by the Court’s narrowing of SEC disgorgement.

Findings
In Liu, the Supreme Court narrowed SEC disgorgement by stating that, as a general matter, SEC disgorgement is not permitted where: (1) the proceeds are not remitted to investors; (2) one defendant is made to disgorge profits that were received by someone else; or (3) the amount of disgorgement fails to deduct legitimate business expenses, in each case subject to possible exemptions as outlined by the Court.

Practical implications
This rule may call into question whether courts may: (a) order disgorgement against insider traders, given the difficulty of identifying investors who have been harmed; (b) order insider traders to disgorge profits earned by others on account of their violations; or (c) order insider traders to pay civil penalties under Section 21 A of the Exchange Act based on profits earned by others.

Originality/Value
Expert analysis and guidance from experienced securities enforcement lawyers with expertise in insider trading.