bluuebunny/crossref_metadata_2025_split huggingface dataset:
δ-protocadherins control neural progenitor cell proliferation by antagonizing Ryk and Wnt/β-catenin signaling
Authors: Biswas Sayantanee , Emond Michelle R. , Chenoweth Kurtis , Jontes James D. 
Published: September 2020

AbstractThe proliferation of neural progenitor cells provides the cellular substrate from which the nervous system is sculpted during development. The δ-protocadherin family of homophilic cell adhesion molecules is essential for the normal development of the nervous system and has been linked to an array of neurodevelopmental disorders. However, the biological functions of δ-protocadherins are not well-defined. Here, we show that the δ-protocadherins regulate proliferation in neural progenitor cells, as lesions in each of six, individual δ-protocadherin genes increase cell division in the developing hindbrain. Moreover, Wnt/β-catenin signaling is upregulated in δ-protocadherin mutants and inhibition of the canonical Wnt pathway occludes the observed proliferation increases. We show that the δ-protocadherins physically associate with the Wnt receptor Ryk, and that Ryk is required for the increased proliferation in protocadherin mutants. Thus, the δ-protocadherins act as novel regulators of Wnt/β-catenin signaling during neural development and could provide lineage-restricted local regulation of canonical Wnt signaling and cell proliferation.
Powered by healthism? Marketing discourses of food and health
Authors: Silchenko Ksenia , Askegaard Søren 
Published: September 2020

PurposeDriven by the visible proliferation of marketing scholarship dedicated to the topics of food marketing and consumer well-being, this study aims to examine the prevailing meanings and assumptions around food and health in marketing research.Design/methodology/approachFollowing the guiding principles of Foucault’s archaeology of knowledge and the methodological orientation of critical discourse analysis, the authors analyze a systematically produced corpus of 190 academic articles from 56 publication outlets.FindingsThe study identifies three discourses of health and food dominant in marketing and consumer research. Each of the three discourses blends the ideology of healthism with market(ing) ideologies and provides a unique perspective on the meanings of health and health risks, the principles of appropriate consumer conduct and the role of marketing in regard to consumer and societal well-being.Research limitations/implicationsThe study contributes to research into ideologies in and of marketing by introducing useful concepts that help explain the role of healthism in marketing discourse.Practical implicationsThe finding of three dominant discourses could help reduce at least some of the existing complexity in regard to conflicting knowledge existing in the domain of health and food, and thus could inspire a more reflective body of work by researchers, policymakers and marketers towards improved food-related well-being.Originality/valueThis analysis of assumptions and consequences of the meanings mobilized by the dominant marketing discourses contributes to a better understanding of the current state of knowledge about health in the market reality.
How could future professionals excel in wine tourism delivery? Evidence from wine regions in emerging economies
Authors: Duarte Alonso Abel , Kok Seng Kiat 
Published: September 2020

Purpose
The purpose of this paper is to investigate the different traits, characteristics and skills future professionals need to contemplate to address the demands of the competitive wine industry, more specifically, concerning the provision of wine tourism experiences. The insights within self-determination theory are considered to develop more robust understanding of this central theme.

Design/methodology/approach
The views of 32 winery representatives in ownership and management roles, operating in two emerging economies were gathered through un-structured, face-to-face interviews conducted on-site.

Findings
Participants’ comments revealed five key dimensions illustrated, notably, through attitudinal aspects (passion, empathy), knowledge-based (constant learning), strategy-based (problem-solver), previous work experience and adaptation-based. This last aspect highlighted coping with the dynamic nature of the industry, while assimilating tasks or learning by doing. These findings have important implications, in particular, for the future delivery of wine tourism experiences.

Originality/value
By empirically examining an important knowledge gap associated with the traits and characteristics of future wine tourism professionals, the study provides original and valuable practical insights. From a theoretical point of view, the study proposes a model originating from the findings and its associations with the revisited theoretical underpinnings.
Do performance measurement models have any impact on primary health care? A systematic review
Authors: Zaadoud Brahim , Chbab Youness , Chaouch Aziz 
Published: September 2020

PurposeThe purpose of this article is to analyze and compare between the frameworks of performance measurement in primary health care in the world. The subject of search is to compare if the frameworks of performance measurement in primary health care have an influence on performances of health centers.Design/methodology/approachWe conducted a systematic review of the literature to (1) identify the conceptual framework for measuring quality management systems, (2) assess the effects of conceptual framework on quality improvement and quality of care outcomes. We opted for the frameworks that are more cited in the literature and we analyzed and compared between these frameworks.FindingsEight dimensions were identified for assessing performance in Primary Health Care Facilities “PHCF” in more than 50% frameworks: Effectiveness, Safety, Accessibility, Equity, Efficiency, Acceptability, Patient Centeredness and Timeliness.Research limitations/implicationsThe limits of this study can be represented by the following elements: (1) lack of exhaustiveness with regard to the current Frameworks. (2) The evaluation of reliability and validity of the qualitative studies remains difficult to appreciate. (3) Most of the evaluation tools of the primary health care are not validated yet. (4) The difference in performance levels between countries, especially for the developed countries and the multitude of the frames of measure of performance, limits the comparability of the results.Practical implicationsThis study provides a conceptual and descriptive literature on the different conceptual frameworks for performance measurement in primary health care, and a practical and useful tool for comparison between the different conceptual frameworks. Several organisations of accreditation or certification introduced, developed, incorporated and checked the indicators of clinical quality in the organizations of health care. Some studies revealed links with the governance, the access, the continuity, the coordination, the efficiency and the strength primary care (Dionne Kringos, 2018). Improvements in the quality of care have been observed in the results of accreditation and certification bodies regarding hospital infection control infrastructure, organization and performance.Originality/valueEven if the links are not established within the framework of a scientific research, quality approaches are generally recognized as an essential tool to help establishments to improve the quality and the safety of the patients. Until now, it is not still common to make evaluation of the quality of care in the “PHCF” to obtain the relevant information. The necessity of having performance measurement tools, which puts in coherence the piloting of the operational level with the strategy, to integrate the organizational objectives into the measures of operational performances and make estimate its structures towards a real management by the quality.
A decision-support approach under uncertainty for evaluating reverse logistics capabilities of healthcare providers in Iran
Authors: Karbassi Yazdi Amir , Wanke Peter Fernandes , Hanne Thomas , Bottani Eleonora 
Published: September 2020

PurposeThis paper aims to assess and prioritize manufacturing companies in the healthcare industry based on critical success factors (CSFs) of their reverse logistics (RL). The research involves seven medical device companies located in the Tehran Province, Iran.Design/methodology/approachTo identify and prioritize companies based on CSFs of RL, the study proposes a three-phase decision-making framework that integrates the Delphi method, the best-worst method (BWM) and the Additive Ratio Assessment (ARAS) method with Z-numbers. The weights required for this method are obtained by a variant of the BWM based on Z-numbers, denoted as Z-numbers Best-Worst Method, or ZBWM. Since decision-makers face an uncertain environment, Z-numbers, which are a kind of fuzzy numbers, are applied.FindingsFirst, after customizing CSFs by the Delphi method and obtaining 15 CSFs of RL, these are ranked by the hybrid BWM-ARAS method with Z-numbers. Results reveal which company appears to perform best with respect to their RL implementations. Based on this result, healthcare device companies should choose the highest priority company based on the selected RL CSFs and results from using the BWM-ARAS method with Z-numbers.Originality/valueThe contribution of this paper is using a hybrid ARAS-BWM method based on Z-numbers. Each of these methods has some merits compared to other similar methods. The combination of these methods contributes a new approach for prioritizing companies based on RL CSFs with high accuracy and reliability.
The intentions to use social commerce from social, technology, and personal trait perspectives: analysis of direct, indirect, and moderating effects
Authors: Handarkho Yonathan Dri 
Published: September 2020

Purpose
This study aims to propose a theoretical model to determine factors affecting an individual’s intentions to use social commerce (SC) in generating and sharing information on a vendor’s products and services. This, however, involves the application of three fundamental aspects including social interaction, social technology and personal trait used in constructing SC to propose these factors.

Design/methodology/approach
A cross-sectional time approach of the quantitative field study was used with the data collected from 874 users of SC in Indonesia using questionnaires.

Findings
The results showed social technology to be the dominant aspect influencing users’ intention to use SC followed by social experience and personality traits while, in detail, perceived enjoyment was discovered to have the most influence and this is in line with the findings of previous studies. Moreover, new results were also identified based on direct, indirect and moderating effects of gender, age and experience.

Originality/value
This research is different from previous ones because of its proposal of an extensive model that combines three main perspectives used in constructing SC and its emphasis on the theoretical and practical importance of studying not only the direct but also the indirect and moderating effects.
The mediating role of transformational leadership between learning culture and knowledge application
Authors: Gil Alfonso J. , Rodrigo-Moya Beatriz , Cegarra-Navarro Juan Gabriel 
Published: September 2020

Purpose
This study aims to analyse the influence of learning culture (LC) and transformational leadership (TL) on knowledge application (KA) in the school context. Mediation analysis is used to quantify the effects that the LC has on the application of leadership, mediated by TL.

Design/methodology/approach
The method involves two samples of subjects – school managers and teaching staff – from 17 educational organisations. This study used the partial least squares method in the SmartPLS.

Findings
The results prove an effect of total mediation of TL.

Originality/value
This study highlights the importance of KA in educational organisations and propounds the responsibility of leadership in educational management.
Tradeoff Assessments for Part Load Controlled Cooling Air in Stationary Gas Turbines
Authors: Woelki Dominik , Peitsch Dieter 
Published: September 2020

AbstractThe demand for flexible part load operation of stationary gas turbines requires the simultaneous design for sufficient efficiency and lifetime. Both can be addressed by the secondary air system. This paper presents investigations on the concepts of cooling air reduction in off-design, aiming for tradeoffs between fuel burn and turbine blade life. The considered lifetime mechanisms are creep and oxidation. In addition, the effects on emissions from the combustion are outlined. The reference gas turbine is a generic gas turbine in the 300 MW power output segment. The focus is on the first two stages of the four-stage turbine. All simulations are performed by application of a coupled model that essentially connects gas turbine performance with a secondary air system network model. This coupled model is now extended with blade life evaluation and emission models. The results contain tradeoffs for operating points at base and part load. For example, the combined cooling air control of stage 1 rotor blade and stage 2 vane offers savings up to 0.5% fuel flow at 60% of base load in a combined cycle application. This saving is at the expense of creep life. However, some operating points could even operate at higher blade temperatures in order to improve life regarding hot corrosion. Furthermore, generic sensitivities of controlled secondary air supply to cooling layers and hot gas ingestion are discussed. Overall, the presented trades mark promising potentials of modulated secondary air system concepts from a technical point of view.
Long-term outcome of transcanalicular microdrill dacryoplasty: a minimally invasive alternative for dacryocystorhinostomy
Authors: Mihailovic Natasa , Blumberg Alina Friederike , Rosenberger Friederike , Brücher Viktoria Constanze , Lahme Larissa , Eter Nicole , Merté Ralph-Laurent , Alnawaiseh Maged 
Published: September 2020

Background/Aim
Dacryocystorhinostomy (DCR) remains the gold standard therapy for nasolacrimal duct obstruction (NLDO), but is invasive and does not maintain the physiology of the lacrimal pathway. With transcanlicular microdrill dacryoplasty (MDP), there is a minimally invasive alternative surgical approach. This study aimed to present this modern lacrimal duct surgery technique and to evaluate its long-term success rate in a large study population.

Methods
The medical records of 1010 patients with acquired NLDO were retrospectively reviewed. Adult patients who had undergone transcanalicular MDP were included. The evaluation included the following parameters: age, gender, success rate, complication rate, obstruction grade and patient satisfaction. Long-term results regarding patient satisfaction and success rate were evaluated by a telephone survey. Only a complete resolution of symptoms was defined as success.

Results
793 eyes of 576 patients after transcanalicular MDP could be included in the study. The mean follow-up time was 8.7±0.9 years. Initial surgical success rate was 84.0%. At the time of the follow-up, 57.5% (n=229) still had full resolution of symptoms. The mean patient satisfaction with the procedure was 6.9±3.2 out of 10 points. Heavy bleeding occurred in two cases only (0.25%).

Conclusion
This is the first study to show the success rate of microendoscopic lacrimal duct surgery after such a long follow-up period and in such a large study population. Transcanalicular MDP is a minimally invasive technique with a very low complication rate and can be used as an alternative procedure before performing more invasive lacrimal duct surgery such as DCR.
Quantification of vascular and neuronal changes in the peripapillary retinal area secondary to diabetic retinopathy
Authors: Frizziero Luisa , Parrozzani Raffaele , Londei Davide , Pilotto Elisabetta , Midena Edoardo 
Published: September 2020

Purpose
To investigate and quantify peripapillary vascular and neuronal changes secondary to diabetic retinopathy, using spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA).

Design
This was a cross-sectional study.

Methods
51 eyes of 51 patients affected by non-proliferative diabetic retinopathy (NPDR) and 19 age-matched healthy control eyes underwent full ophthalmic examination, including OCT and OCTA in the peripapillary area. Vessel area density (VAD), vessel length fraction (VLF) and vessel diameter index (VDI) were quantified in a ring-shaped region of interest of each OCTA image. Capillaries and larger vessels were separately analysed. The thickness of the peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell complex (GCC) was also analysed.

Results
VAD and VLF of peripapillary capillaries were significantly reduced in NPDR eyes, along with the progression of NPDR (p<0.05). VDI was significantly reduced in mild (p=0.0093) and moderate (p=0.0190) NPDR eyes, but not in severe NPDR (p=0.0841). Larger peripapillary vessels showed a significant increase of both VAD and VDI in NPDR eyes. pRNFL and GCC thickness decreased in NPDR eyes, reaching statistical significance only for GCC. No statistically significant correlation was found between perfusion parameters and pRNFL and GCC thickness.

Conclusions
Retinal capillary remodelling in NPDR involves the peripapillary vascularisation too, as confirmed by OCTA quantitative parameters. The peripapillary macrovasculature and microvasculature need to be separately evaluated. The lack of direct correlation between peripapillary capillaries changes and the loss of retinal nerve fibres suggests that neuronal damage cannot be simply considered secondary to the microvascular one.
Acceptability and feasibility of two interventions in the MooDFOOD Trial: a food-related depression prevention randomised controlled trial in overweight adults with subsyndromal symptoms of depression
Authors: Owens Matthew , Watkins Edward , Bot Mariska , Brouwer Ingeborg Annemarie , Roca Miquel , Kohls Elisabeth , Penninx Brenda , van Grootheest Gerard , Cabout Mieke , Hegerl Ulrich , Gili Margalida , Visser Marjolein 
Published: September 2020

ObjectivesWe report on the acceptability, feasibility, dose-response relationship and adherence of two nutritional strategies to improve mood (multinutrient supplements; food-related behavioural activation (F-BA)) studied in a randomised controlled depression prevention trial (the Multi‐country cOllaborative project on the rOle of Diet, Food‐related behaviour, and Obesity in the prevention of Depression (MooDFOOD) Trial). We also assessed baseline determinants of adherence and assessed whether better adherence resulted in lower depressive symptoms.DesignRandomised controlled trial with a 2×2 factorial design conducted between 2015 and 2017.SettingGermany, the Netherlands, UK and Spain.ParticipantsCommunity sample of 1025 overweight adults with elevated depressive symptoms without a current episode of major depressive disorder. Main eligibility criteria included age (18–75 years), being overweight or obese, and having at least mild depressive symptoms, shown by a Patient Health Questionnaire Score of ≥5. A total of 76% of the sample was retained at the 12-month follow-up.InterventionsDaily nutritional supplements versus pill placebo or an F-BA therapy, delivered in individual and group sessions versus no behavioural intervention over a 1-year period.Primary and secondary outcome measuresPrimary outcome: self-reported acceptability of the interventions. Secondary outcomes: adherence and self-reported depressive symptoms.ResultsMost participants reported that the F-BA was acceptable (83.61%), feasible to do (65.91%) and would recommend it to a friend (84.57%). Individual F-BA sessions (88.10%) were significantly more often rated as positive than group F-BA sessions (70.17%) and supplements (28.59%). There were statistically significant reductions in depressive symptoms for those who both adhered to the F-BA intervention and had a history of depression (B=−0.08, SE=0.03, p=0.012) versus those who had no history of depression. Supplement intake had no effect on depressive symptoms irrespective of adherence.ConclusionsF-BA may have scope for development as a depression prevention intervention and public health strategy but further refinement and testing are needed.Trial registration numberNCT02529423.
Cost–utility and budget impact analysis of tocilizumab for the treatment of refractory systemic juvenile idiopathic arthritis in Thailand
Authors: Kittiratchakool Nitichen , Kulpokin Disorn , Chanjam Chonticha , Vilaiyuk Soamarat , Charuvanij Sirirat , Phongsamart Gun , Khaosut Parichat , Tanya Manasita , Nanagara Ratanavadee , Nantapaisarn Sira , Leelahavarong Pattara 
Published: September 2020

ObjectivesThis study aimed to analyse the cost–utility and budget impact of adding tocilizumab to the standard treatment for patients with refractory systemic juvenile idiopathic arthritis (sJIA) in Thailand.DesignEconomic evaluation using a decision-analytical model.SettingThailand.ParticipantsPatients with refractory sJIA who were ≥2 years old.MethodsThe use of tocilizumab as an add-on therapy to standard treatment was compared with standard treatment alone. A simulated health state transition model was used to estimate the lifetime costs and health outcomes from a societal perspective. Direct medical costs were collected from tertiary hospital databases while direct non-medical costs were derived from interviews. Health-related quality of life (QoL) was measured using the proxy version of three-level EuroQol five-dimensional questionnaire (EQ-5D-3L). Future costs and outcomes were discounted at an annual rate of 3%. The base case population was patients aged 9.41 years old at refractory disease onset. The results were reported as incremental cost-effectiveness ratios (ICER) in US dollar (USD). One-way and probabilistic sensitivity analysis were conducted to investigate parameter uncertainty. The 5-year budget impact was estimated from a governmental perspective.ResultsThe ICER of standard treatment plus tocilizumab was US$35 799 per quality-adjusted life-year (QALY) gained compared with standard treatment alone, which was not cost-effective at the threshold of US$5128 per QALY gained. The estimated 5 years budget impact was approximately US$4.8 million.ConclusionsThe use of standard treatment plus tocilizumab was not cost-effective in the Thai context, which has limited data. However, there is currently no second-line treatment for refractory sJIA in the Thai National List of Essential Medicines; thus, patients must receive higher doses of standard treatment which can cause many side effects. In contrast, tocilizumab showed obvious efficacy in clinical trials in improving treatment response and QoL. Therefore, the price of tocilizumab should be negotiated to reduce the financial impact on the healthcare system.