bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propensity-matched Analysis Demonstrates Long-term Risk of Respiratory and Cardiac Mortality After Pneumonectomy Compared With Lobectomy for Lung Cancer
Authors: Jones Gregory D. , Caso Raul , Tan Kay See , Dycoco Joseph , Adusumilli Prasad S. , Bains Manjit S. , Downey Robert J. , Huang James , Isbell James M. , Molena Daniela , Park Bernard J. , Rocco Gaetano , Rusch Valerie W. , Sihag Smita , Jones David R. , Bott Matthew J. 
Published: June 2020

Objective:
We sought to quantify and characterize long-term consequences of pneumonectomy, with particular attention to nononcologic mortality.

Summary of Background Data:
Pneumonectomy is associated with profound changes in cardiopulmonary physiology. Studies of long-term outcomes after pneumonectomy typically report generalized measures, such as disease-free and overall survival.

Methods:
Patients undergoing lobectomy or pneumonectomy for lung cancer at our institution from 2000 to 2018 were reviewed. Propensity-score matching was performed for 12 clinicopathologic factors. Ninety-day complications and deaths were compared. Five-year cumulative incidence of oncologic and nononcologic mortality were compared using competing risks approaches.

Results:
From 3339 lobectomy and 355 pneumonectomy patients identified, we derived 318 matched pairs. At 90 days, rates of overall complications were similar (46% for pneumonectomy vs 43% for lobectomy; P = 0.40), but rates of major complications (21% vs 13%; P = 0.005) and deaths (6.9% vs 1.9%; P = 0.002) were higher the pneumonectomy cohort. The cumulative incidence of oncologic mortality was not significantly different between cohorts (P = 0.9584). However, the cumulative incidence of nononcologic mortality was substantially higher in the pneumonectomy cohort for both date of surgery and 1-year landmark analyses (P < 0.0001 and P = 0.0002, respectively). Forty-five pneumonectomy patients (18%) died of nononcologic causes 1–5 years after surgery; pneumonia (n = 21) and myocardial infarction (n = 10) were the most common causes. In pneumonectomy patients, preexisting cardiac comorbidity and low diffusion capacity of the lungs for carbon monoxide were predictive of nononcologic mortality.

Conclusions:
Compared to lobectomy, excess mortality after pneumonectomy extends beyond 1 year and is driven primarily by nononcologic causes. Pneumonectomy patients require lifelong monitoring and may benefit from expeditious assessment and intervention at the initial signs of illness.
The Prevalence of Pelvic Floor Hematoma After Vaginal Delivery
Authors: Denson Lindsay E. , Terrell Deirdra R. , Vesely Sara K. , Peck Jennifer D. , Quiroz Lieschen H. , Shobeiri S. Abbas 
Published: June 2020

Objective
The goal of this study was to evaluate differences in levator ani hematoma formation within 3 days of delivery between adult women after their first vaginal delivery and adult women who have had multiple vaginal deliveries.

Methods
This was a cross-sectional study at a single institution from 2013 to 2015 using a high-resolution endovaginal ultrasound transducer to identify postvaginal delivery hematoma formation. Logistic regression was used to examine the association between hematoma formation and vaginal parity while considering potential confounders including induction, vaginal operative delivery, vaginal birth after cesarean, fetal weight, fetal head circumference, race and ethnicity, body mass index, age at delivery, gestational age, and length of second-stage labor.

Results
Ninety women (46 vaginal-primiparous; 44 vaginal-multiparous) were included in this study. After adjusting for oxytocin use, length of second-stage labor, and body mass index, the odds of pelvic floor hematoma of 1000 mm3 or greater were 2.93 (95% confidence interval, 0.78–10.91) times greater in women after their first vaginal delivery compared with women with a history of multiple vaginal deliveries. The adjusted odds of pelvic floor hematoma of 1500 mm3 or greater were 6.02 (95% confidence interval, 1.09–33.24) times greater in vaginal-primiparous compared with vaginal-multiparous women.

Conclusions
Although the prevalence of pelvic floor hematoma was higher in vaginal-primiparous women than vaginal-multiparous women after vaginal delivery, hematomas were present in both groups. Future prospective studies are needed to evaluate the additive effect of multiple vaginal deliveries on the pelvic floor.
Design of a Randomized Clinical Trial of Perioperative Vaginal Estrogen Versus Placebo With Transvaginal Native Tissue Apical Prolapse Repair (Investigation to Minimize Prolapse Recurrence of the Vagina using Estrogen: IMPROVE)
Authors: Rahn David D. , Richter Holly E. , Sung Vivian W. , Larsen Wilma I. , Hynan Linda S. 
Published: June 2020

Objectives
To provide the rationale and design for a randomized, double-blind clinical trial of conjugated estrogen vaginal cream (applied for at least 5 weeks preoperatively and continued twice-weekly through 12 months postoperatively) compared with placebo in postmenopausal women with symptomatic pelvic organ prolapse undergoing a standardized transvaginal native tissue apical repair.

Methods
Study population, randomization process, study cream intervention, masking of participants and evaluators, placebo cream manufacture, standardized surgical intervention, and collection of adverse events are described. The primary outcome of surgical success is a composite of objectively no prolapse beyond the hymen and the vaginal cuff descending no more than one third the vaginal length; subjectively, no sense of vaginal pressure or bulging; and no retreatment for prolapse at 12 months. Time-to-failure postoperatively will be compared in the 2 groups with continued surveillance to 36 months. Secondary outcomes assessed at baseline, preoperatively (ie, after at least 5 weeks of study cream), and postoperatively at 6 month intervals include validated condition-specific and general quality-of-life metrics, overall impression of improvement, sexual function, vaginal atrophy symptoms, and body image. Challenges unique to this study include design and manufacture of placebo and defining and measuring study drug adherence.

Results
Recruitment of 204 women is complete with 197 randomized. There have been 174 surgeries completed with 15 more pending; 111 have completed their 12 month postoperative visit.

Conclusions
This trial will contribute evidence-based information regarding the effect of perioperative vaginal estrogen as an adjunct therapy to standardized transvaginal native tissue prolapse surgical repair.
Abdominal Normothermic Regional Perfusion in Donation After Circulatory Death: A Systematic Review and Critical Appraisal
Authors: van de Leemkolk Fenna E.M. , Schurink Ivo J. , Dekkers Olaf M. , Oniscu Gabriel C. , Alwayn Ian P.J. , Ploeg Rutger J. , de Jonge Jeroen , Huurman Volkert A.L. 
Published: June 2020

Background.
Abdominal normothermic regional perfusion (aNRP) for donation after circulatory death is an emerging organ preservation technique that might lead to increased organ utilization per donor by facilitating viability testing, improving transplant outcome by early reversal of ischemia, and decreasing the risk of unintentional surgical damage. The aim of the current review is to evaluate the recent literature on the added value of aNRP when compared to local standard perfusion technique.

Methods.
The Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline for systematic reviews was used, and relevant literature databases were searched. Primary outcomes were organ utilization rate and patient and graft survival after 1 year. Secondary outcomes included delayed graft function, primary nonfunction, serum creatinine, and biliary complications.

Results.
A total of 24 articles were included in this review. The technique is unanimously reported to be feasible and safe, but the available studies are characterized by considerable heterogeneity and bias.

Conclusions.
Uniform reported outcome measures are needed to draw more definitive conclusions on transplant outcomes and organ utilization. A randomized controlled trial comparing aNRP with standard procurement technique in donation after circulatory death donors would be needed to show the added value of the procedure and determine its place among modern preservation techniques.
Low-dose Aripiprazole Induced Enuresis Continuum in a Child
Authors: Karatoprak Serdar , Uzun Necati 
Published: June 2020

Abstract
Aripiprazole is an atypical antipsychotic commonly used in the treatment of childhood disorders, such as bipolar disorder, psychosis, and irritability associated with autism spectrum disorder. Common side effects of its use include extrapyramidal side effects, somnolence, tremor, fatigue, nausea, and akathisia. Enuresis is an additional and rare side effect of aripiprazole use. There is limited data on the subject of enuresis induced as a result of treatment with aripiprazole. To our knowledge, there are no reports in the literature on aripiprazole-induced enuresis continuum in children. In this report, we present the case of a 9-year-old boy who developed enuresis continuum after the initiation of a low dose of aripiprazole and describe his rapid improvement when administration of the drug was ended.
Rhodococcus cavernicola sp. nov., isolated from a cave, and Rhodococcus degradans is a later heterosynonym of Rhodococcus qingshengii
Authors: Lee Soon Dong , Kim In Seop , Kim Young-Ju , Joung Yochan 
Published: June 2020

A Gram-reaction-positive, strictly aerobic, catalase-positive, oxidase-negative, non-motile actinobacterium, designated C1-24T, was isolated from a soil sample collected inside a natural cave. The organism exhibited a rod–coccus developmental cycle during its growth phase. Results of 16S rRNA gene-based phylogenetic analysis showed that the novel strain belonged to the genus

Rhodococcus

and formed a distinct sublineage at the base of the radiation including a Rhodococcus enclensis–Rhodococcus kroppenstedtii–Rhodococcus corynebacterioides–Rhodococcus trifoli cluster. In the results of phylogenomic analysis, the novel strain was loosely associated to

Rhodococcus corynebacterioides

. The closest relatives were

Rhodococcus qingshengii

(98.01 % 16S rRNA gene sequence similarity) and

Rhodococcus degradans

(98.01 %). The genome size was 5.66 Mbp and the DNA G+C content was 64.30 mol%. Whole-cell hydrolysates contained meso-diaminopimelic acid, arabinose and galactose as the diagnostic diamino acid and sugars. MK-8(H2) was the predominant menaquinone. The polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, an unidentified glycolipid and three unidentified phospholipids. Mycolic acids were present. The major fatty acids were C16 : 0, C18 : 1
ω9c, C16 : 1
ω7c and/or C16 : 1
ω6c and 10-methyl C18 : 0. Digital DNA–DNA hybridization and average nucleotide identity values revealed that the novel strain should be assigned to a different species. Based on the combined data obtained here, strain C1-24T (=KACC 19964T=DSM 109484T) represents a new species of the genus

Rhodococcus

, for which Rhodococcus cavernicola sp. nov. is proposed. Also, it is proposed that

R. degradans

is a later heterosynonym of

R. qingshengii

based on analyses of 16S rRNA gene and whole-genome sequences.
CTDPathSim: Cell line-tumor deconvoluted pathway-based similarity in the context of precision medicine in cancer*
Authors: Bose Banabithi , Bozdag Serdar 
Published: June 2020

ABSTRACTIn cancer research and drug development, human tumor-derived cell lines are used as popular model for cancer patients to evaluate the biological functions of genes, drug efficacy, side-effects, and drug metabolism. Using these cell lines, the functional relationship between genes and drug response and prediction of drug response based on genomic and chemical features have been studied. Knowing the drug response on the real patients, however, is a more important and challenging task. To tackle this challenge, some studies integrate data from primary tumors and cancer cell lines to find associations between cell lines and tumors. These studies, however, do not integrate multi-omics datasets to their full extent. Also, several studies rely on a genome-wide correlation-based approach between cell lines and bulk tumor samples without considering the heterogeneous cell population in bulk tumors. To address these gaps, we developed a computational pipeline, CTDPathSim, a pathway activity-based approach to compute similarity between primary tumor samples and cell lines at genetic, genomic, and epigenetic levels integrating multi-omics datasets. We utilized a deconvolution method to get cell type-specific DNA methylation and gene expression profiles and computed deconvoluted methylation and expression profiles of tumor samples. We assessed CTDPathSim by applying on breast and ovarian cancer data in The Cancer Genome Atlas (TCGA) and cancer cell lines data in the Cancer Cell Line Encyclopedia (CCLE) databases. Our results showed that highly similar sample-cell line pairs have similar drug response compared to lowly similar pairs in several FDA-approved cancer drugs, such as Paclitaxel, Vinorelbine and Mitomycin-c. CTDPathSim outperformed state-of-the-art methods in recapitulating the known drug responses between samples and cell lines. Also, CTDPathSim selected higher number of significant cell lines belonging to the same cancer types than other methods. Furthermore, our aligned cell lines to samples were found to be clinical biomarkers for patients’ survival whereas unaligned cell lines were not. Our method could guide the selection of appropriate cell lines to be more intently serve as proxy of patient tumors and could direct the pre-clinical translation of drug testing into clinical platform towards the personalized therapies. Furthermore, this study could guide the new uses for old drugs and benefits the development of new drugs in cancer treatments.CCS CONCEPTSComputational biologyGenomicsSystems biologyBioinformaticsGeneticsACM Reference formatBanabithi Bose, Serdar Bozdag. 2020. CTDPathSim: Cell line-tumor deconvoluted pathway-based similarity in the context of precision medicine in cancer.
Orthotopic Transplantation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Alveolar Progenitor Cells into Murine Lungs
Authors: Weiner Aaron I. , Fernandez Rafael , Zhao Gan , Palashikar Gargi , de Mello Costa Maria Fernanda , Adams Stephanie , Lengner Christopher J. , Johnson F. Brad , Vaughan Andrew E. 
Published: June 2020

ABSTRACTHumanized mice possessing human cells, tissues, or organ systems provide an unparalleled platform for preclinical studies in oncology, immunology, and infectious diseases. While the lungs are a vital organ subject to a wide variety of pathologies, exemplified by the ongoing COVID-19 pandemic, discrete differences in murine and human lungs can obfuscate interpretation of murine models of lung disease. Here we provide proof-of-concept methodology for the potential humanization of murine lungs via orthotopic transplantation of human NKX2.1+ progenitor cells and alveolar type 2 cells derived from induced pluripotent stem cells. We show that these cells engraft readily into highly immunocompromised mice after pharmacological injury with bleomycin, which presumably generates “space” for human cells to access denuded basement membrane and engraft. Transplanted cells stably retain their pulmonary lineage restriction and persist as superficially differentiated alveolar type 2 and type 1 cells. Future work should focus on strategies to promote xenorepopulation of most / all of the murine lung with human cells while retaining appropriate regio-specific epithelial differentiation and normal physiological function.
Evaluation of Field Sampling Techniques for Environmental Microbial Exposure: Assessing Efficacy and Feasibility
Authors: Dalton Kathryn R. , Spicer Kristoffer , Ludwig Shanna , Clemons-Erby Dorothy , Green Timothy , Rule Ana M. , Koehler Kirsten , McCormack Meredith C. , Davis Meghan F. 
Published: June 2020

AbstractEnvironmental exposures in schools, including microbial exposures, can lead to detrimental childhood health outcomes. We evaluated two sampling techniques – standard flocked swabs versus sterile electrostatic cloths – to quantifyStaphylococcusbacterial burden from school surfaces. Electrostatic cloths demonstrated higher test sensitivity and yielded higher surface area-standardized colony forming units compared to swabs. Despite protocol standardization, consistently larger surface areas were sampled with electrostatic cloths. This suggest that electrostatic cloths were more effective and practical for fieldwork.
Evolutionary phenome-genome analysis of cranial suture closure in mammals
Authors: Esteve-Altava Borja , Barteri Fabio , Farré Xavier , Muntané Gerard , Pastor Juan Francisco , Navarro Arcadi 
Published: June 2020

ABSTRACTCranial sutures are growth and stress diffusion sites that connect the bones protecting the brain. The closure of cranial suture is a key feature of mammalian late development and evolution, which can also lead to head malformations when it occurs prematurely (craniosynostosis). To unveil the phenotypic and genetic causes of suture closure in evolution, we examined 48 mammalian species searching for (i) causal links between suture patency, brain size, and diet using phylogenetic path analysis; and (ii) instances of genome-phenome convergence amino acid substitutions. Here we show that brain size and the anteroposterior order of ossification of the skull are the two main causes of sutures patency in evolution. We also identified three novel candidate genes for suture closure in evolution (HRNR,KIAA1549, andTTN), which have never been reported in clinical studies of craniosynostosis. Our results suggest that different genetic pathways underlie cranial suture closure in evolution and disease.
Consumer preferences for three dimensions of country of origin of a processed food product
Authors: Aizaki Hideo , Sato Kazuo 
Published: June 2020

PurposeThe production process of processed food products may involve several countries. This multi-dimensionality of the country of origin (COO) may affect consumer preferences for the products. We apply Case 2 best–worst scaling to measure Japanese consumers’ preferences for three dimensions of the COO of a vegetable juice product.Design/methodology/approachThe three dimensions of the COO include these: the country where the raw materials of the product were grown (the country of growing), the country where the raw materials were processed (the country of processing) and the country where the food company producing the product is headquartered (the country of the company). Japan, Australia, Thailand and China are the countries considered for the three COO-related attributes. Sixteen juice products (profiles) were created from the three four-level attributes. A survey queried 416 consumers to select the best and worst ones from among the three attribute levels shown in each profile.FindingsThe average utility of the country of growing is the highest among those of the three COO-related attributes. However, consumers evaluate the country of growing as the least preferred among the three attributes with respect to a country with a negative food quality reputation.Originality/valueThis is the first Case 2 best–worst scaling study to measure consumer preferences for the three dimensions of the COO of processed food products. It suggests marketing strategies for domestic and international juice companies.
Food-related lifestyle segmentation and beverage attribute' selection: toward understanding of sugar-reduced beverages choice
Authors: Yeo Ga Eun , Cho Mi-Sook , Oh Jieun 
Published: June 2020

PurposeAs the risks associated with sugar-sweetened beverages (SSBs) increase, various policies require sugar to be reduced in beverages. This paper segmented consumers according to food-related lifestyle (FRL), analyzed beverage selection attributes and preference for sugar-reduced beverages (SRBs) for each group and presented basic data for the strategies of SRBs for each consumer group.Design/methodology/approachIn total, 1,000 Korean consumer panels responded to the online survey. The questionnaire consisted of FRL, beverage selection attributes and attitude toward SRBs.FindingsConsumer groups were divided according to FRL: rational, value seeking and careless consumer. Rational consumers tended to be in their 30s or 50s and women, and they focused on product quality/hygiene when choosing beverages. Value seeking consumers were mainly in their 40s and 50s and were characterized by high education and income. They showed high scores in quality/hygiene, economy and sensory traits. Careless consumers were more likely to be in their 20s–30s, unmarried men and considered sensory traits as the most important factor.Research limitations/implicationsThe main limitation of this study is the lack of generalization of consumer panels to represent the entire population because they were part of an online research firm.Originality/valueThis study implies that segmenting consumers according to FRL allows detailed analysis of consumer attitudes and behaviors. Using this analysis, the complex consumer pattern can be used as basic data for promoting sugar-reduced beverages.
A new conceptual framework for identifying the factors influencing the effectiveness of competitive intelligence
Authors: Asghari Somayeh , Targholi Sahar , Kazemi Ali , Shahriyari Saeed , Rajabion Lila 
Published: June 2020

Purpose
Competitive intelligence (CI) collects data through the distribution of knowledge to make decisions in a competitive environment. To better comprehend the concept of CI, the purpose of this paper is to determine the role of effective factors (knowledge sharing, competitor information, information technology (IT) and organizational culture) and their impact on CI. In addition, the paper provides a conceptual framework for determining the practical factors on CI.

Design/methodology/approach
For evaluating the elements of the model, a questionnaire is considered. Questionnaires were reread by specialists with significant experiences in the CI field. For statistical analysis, the SPSS 22 and SmartPLS 3.2 software package is also used.

Findings
Findings from the study showed the validity of the model for a CI assessment. Furthermore, the results confirmed that the competitor information significantly influenced CI. In addition, the obtained results implied that IT has a significant and positive influence on CI. The effect of organizational culture on CI also proved to be positive and significant.

Research limitations/implications
This paper makes significant contributions for both researchers and practitioners; however, the authors determine some limitations, which are as follows: First, the authors showed the result in a single region. It cannot be assured that the results are generalizable to other areas. Second, because of time and financial constraints, the authors gathered the data using a sample from a single location. Third, the use of variables to depict CI may be not exhaustive. The authors, therefore, encourage future research to study these CI dimensions.

Practical implications
This study meaningfully contributes to the knowledge and literature by focusing more on CI, examining other significant aspects and applying advanced statistical analysis method. Also, current research results suggest practical implications for marketing practitioners and managers who implemented tools and made strategic plans to enhance the organization’s performance. From a practical perspective, the statistical results support the crucial role of the following factors: IT, competitor information, organizational culture and knowledge sharing on CI.

Originality/value
Experts in the area of knowledge management, CI and strategic management can use this study to gain a competitive advantage based on knowledge and information resources. Organizations must have knowledge management function and CI to support the strategy formulation, implementation and evaluation.