bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Hybrid Molecules for the Visualization of Cancer: PESIN‐Homodimers Combined with Multimodal Molecular Imaging Probes for Positron Emission Tomography and Optical Imaging: Suited for Tracking of GRPR‐Positive Malignant Tissue**
Authors: Hübner Ralph , Cheng Xia , Wängler Björn , Wängler Carmen 
Published: July 2020

AbstractWe describe multimodal imaging probes for gastrin‐releasing peptide receptor (GRPR)‐specific targeting suited for positron emission tomography and optical imaging (PET/OI), consisting of PESIN (PEG3‐BBN7‐14) dimers connected to multimodal imaging subunits. These multimodal agents comprise a fluorescent dye for OI and the chelator ((1,4,7‐triazacyclononane‐4,7‐diyl)diacetic acid‐1‐glutaric acid) (NODA‐GA) for PET radiometal isotope labelling. Special focus was put on the influence of the used dyes on the properties of the whole bioconjugates. For this, several compounds with different fluorescent dyes and non‐dye carrying subunits were synthesized and investigated. As fluorescent dyes, dansyl, NBD, derivatives of fluorescein, coumarin and rhodamine as well as three pyrilium‐based dyes were employed. Considerable influence of the charge of the colored unit on hydrophilicity as well as in vitro target receptor binding was observed and classified. High radiochemical yields and purities were found during radiolabeling of the multimodal imaging subunits as well as their GRPR‐specific bioconjugates with 68Ga. Examinations of the photophysical properties of both molecule species displayed no loss or alteration of fluorescence characteristics.
Highly Conjugated π‐Systems Arising from Cannibalistic Hexadehydro‐Diels–Alder Couplings: Cleavage of C−C Single and Triple Bonds
Authors: Maier Jan , Deutsch Marian , Merz Julia , Ye Qing , Diamond Oliver , Schilling Maja‐Tessa , Friedrich Alexandra , Engels Bernd , Marder Todd B. 
Published: July 2020

AbstractWe have investigated the cannibalistic self‐trapping reaction of an ortho‐benzyne derivative generated from 1,11‐bis(p‐tolyl)undeca‐1,3,8,10‐tetrayne in an HDDA reaction. Without adding any specific trapping agent, the highly reactive benzyne is trapped by another bisdiyne molecule in at least three different modes. We have isolated and characterized the resulting products and performed high‐level calculations concerning the reaction mechanism. During the cannibalistic self‐trapping process, either a C≡C triple bond or an sp–sp3 C−C single bond is cleaved. Up to seven rings and nine C−C bonds are formed starting from two 1,11‐bis(p‐tolyl)undeca‐1,3,8,10‐tetrayne molecules. Our experiments and calculations provide considerable insight into the variety of reaction pathways which the ortho‐benzyne derivative, generated from a bisdiyne, can take when reacting with another bisdiyne molecule.
Charge‐Separated and Lewis Paired Metal–Organic Framework for Anion Exchange and CO2 Chemical Fixation
Authors: Thapa Sheela , Meng Lingyao , Hettiarachchi Eshani , Bader Yousef K. , Dickie Diane A. , Rubasinghege Gayan , Ivanov Sergei A. , Vreeland Erika C. , Qin Yang 
Published: July 2020

AbstractCharge‐separated metal–organic frameworks (MOFs) are a unique class of MOFs that can possess added properties originating from the exposed ionic species. A new charge‐separated MOF, namely, UNM‐6 synthesized from a tetrahedral borate ligand and Co2+ cation is reported herein. UNM‐6 crystalizes into the highly symmetric P43n space group with fourfold interpenetration, despite the stoichiometric imbalance between the B and Co atoms, which also leads to loosely bound NO3− anions within the crystal structure. These NO3− ions can be quantitatively exchanged with various other anions, leading to Lewis acid (Co2+) and Lewis base (anions) pairs within the pores and potentially cooperative catalytic activities. For example, UNM‐6‐Br, the MOF after anion exchange with Br− anions, displays high catalytic activity and stability in reactions of CO2 chemical fixation into cyclic carbonates.
Mechanisms, Methods of Tracking and Applications of DNA Walkers: A Review
Authors: Valero Julián , Škugor Marko 
Published: July 2020

AbstractIn recent years, DNA nanotechnology expanded its scope from structural DNA nanoarchitecture towards designing dynamic and functional nanodevices. This progress has been evident in the development of an advanced class of DNA nanomachines, the so‐called DNA walkers. They represent an evolution of basic switching between distinctly defined states into continuous motion. Inspired by the naturally occurring walkers such as kinesin, research on DNA walkers has focused on developing new ways of powering them and investigating their walking mechanisms and advantages. New techniques allowing the visualization of walkers as single molecules and in real time have provided a deeper insight into their behavior and performance. The construction of novel DNA walkers bears great potential for applications in therapeutics, nanorobotics or computation. This review will cover the various examples and breakthrough designs of recently reported DNA walkers that pushed the limits of their performance. It will also mention the techniques that have been used to investigate walker nanosystems, as well as discuss the applications that have been explored so far.
Retracted: Green human resource management and employees' green creativity: The roles of green behavioral intention and individual green values
Authors: Al‐Ghazali Basheer M. , Afsar Bilal 
Published: July 2020

RetractionAl‐Ghazali, BM, Afsar, B. Green human resource management and employees' green creativity: The roles of green behavioral intention and individual green values. Corp Soc Responsib Environ Manag. 2020; 1–18. https://doi.org/10.1002/csr.1987]The above article, published online on 2nd July 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Richard Welford and John Wiley and Sons Ltd. The retraction has been agreed due to unattributed overlap between this article and the following article under review with the Social Responsibility Journal: Ojo, Tan and Mazni SRJ‐12‐2019‐0403.R3: Linking Green HRM practices to environmental performance through pro‐environment behaviour in the Information Technology sector.
Simultaneous spectrum sensing, data transmission and Energy harvesting in multi‐channel cognitive sensor Networks with imperfect signal cancellation
Authors: Najimi Maryam 
Published: July 2020

SummaryIn multichannel cognitive sensor networks, the sensor users which have limited energy budgets sense the spectrum to determine the activity of the primary user. If the spectrum is idle, the sensor user can access the licensed spectrum. However, during the spectrum sensing, no data transmits. For improving the network throughput and saving more energy consumption, we propose the simultaneous spectrum sensing and data transmission scheme where the sensor receiver decodes the received signal, and from the remaining signal, the status of the channel (idle/busy) is determined. We also consider that the sensor users are powered by a radio‐frequency (RF) energy harvester. In this case, energy harvesting, data transmission, and spectrum sensing are done simultaneously. On the other hand, we select the proper sensor users for spectrum sensing and energy harvesting. We also allocate the best channels for data transmission simultaneously so that the network throughput maximizes and the constraints on the energy consumption and the detection performance are satisfied for each band. We formulate the problem and model it as a coalition game in which sensors act as game players and decide to make coalitions. Each coalition selects one of the channels to sense and transmit data, while the necessary detection probability and false alarm probability and also the energy consumption constraints are satisfied. The utility function of a coalition is proposed based on the energy consumption, false alarm probability, detection probability, and the network throughput. This paper proposes an efficient algorithm to reach a Nash‐stable coalition structure. It is demonstrated that the proposed method maximizes the network throughput and reduces the energy consumption while it provides sufficient detection quality, in comparison to other existent methods.
Sex‐specific alterations in GABA receptor‐mediated responses in laterodorsal tegmentum are associated with prenatal exposure to nicotine
Authors: Eliasen Jannik Nicklas , Krall Jacob , Frølund Bente , Kohlmeier Kristi A. 
Published: July 2020

AbstractSmoking during pregnancy is associated with deleterious physiological and cognitive effects on the offspring, which are likely due to nicotine‐induced alteration in the development of neurotransmitter systems. Prenatal nicotine exposure (PNE) in rodents is associated with changes in behaviors controlled in part by the pontine laterodorsal tegmentum (LDT), and LDT excitatory signaling is altered in a sex and age‐dependent manner by PNE. As effects on GABAergic LDT signaling are unknown, we used calcium imaging to evaluate GABAA receptor‐ (GABAAR as well as GABAA‐ρR) and GABAB receptor (GABABR)‐mediated calcium responses in LDT brain slices from female and male PNE mice in two different age groups. Overall, in older PNE females, changes in calcium induced by stimulation of GABAAR and GABABR, including GABAA‐ρR were shifted toward calcium rises. In both young and old males, PNE was associated with alterations in calcium mediated by all three receptors; however, the GABAAR was the most affected. These results show for the first time that PNE is associated with alterations in GABAergic transmission in the LDT in a sex‐ and age‐dependent manner, and these data are the first to show PNE‐associated alterations in functionality of GABA receptors in any nucleus. PNE‐associated alterations in LDT GABAergic transmission within the LDT would be expected to alter output to target regions and could play a role in LDT‐implicated, negative behavioral outcomes following gestational exposure to smoking. Accordingly, our data provide further supportive evidence of the importance of eliminating the consumption of nicotine during pregnancy.
Stability study of α‐bromophenylacetic acid: Does it represent an appropriate model analyte for chiral separations?
Authors: Jáč Pavel , Bubáková Zuzana , Moreno‐González David , Kováčová Gabriela , Špulák Marcel , Polášek Miroslav 
Published: July 2020

AbstractThe stability of α‐bromophenylacetic acid (BPAA) in 50% aqueous methanol solution has been tested. CE in different running buffers was used to separate BPAA from the decomposition reaction products α‐hydroxyphenylacetic (mandelic) acid and α‐methoxyphenylacetic acid. Suitable CE separation of all three compounds and other product, bromide, was achieved in 60 mmol/L formate buffer (pH 3.0) at −30 kV in 50 μm (i.d.) poly(vinyl alcohol)‐coated fused silica capillary (30 cm/24.5 cm) with UV detection at 200 nm. The CE method was applied to determine the reaction order of the decomposition of BPAA (0.47 mmol/L) via nucleophilic substitution in 50% aqueous methanol. The first‐order reaction kinetics was confirmed by linear and non‐linear regression, giving the rate constants 1.52 × 10−4 ± 2.76 × 10−5 s−1 and 7.89 × 10−5 ± 5.02 × 10−6 s−1, respectively. Additionally, the degradation products were identified by CE coupled to mass spectrometric (MS) detection. The CE–MS experiments carried out in 60 mmol/L formate buffer (pH 3.0) and in 60 mmol/L acetate buffer (pH 5.0) confirmed the results obtained by CE–UV. Furthermore, the stability of BPAA in polar solvents was tested by 1H NMR experiments. Our results provide strong evidence of the instability and fast degradation of BPAA in 50% aqueous methanol indicating that BPAA is not suitable as the model analyte for chiral separations.
An efficient approach for whirling speeds and mode shapes of uniform and nonuniform Timoshenko shafts mounted by arbitrary rigid disks
Authors: Wu Jong‐Shyong , Hsu Tzu‐Fu 
Published: July 2020

AbstractIn theory, the whirling motion of a shaft‐disk system is three‐dimensional (3D), however, if the transverse displacement in the vertical principal xy‐plane and that in the horizontal principal xz‐plane for the cross‐section of the shaft located at the axial coordinate x are represented by a complex number, then the mass moment of inertia for unit shaft length (at x) and that for each rigid disk i can be combined with their associated gyroscopic moments (GMs) to form the frequency‐dependent equivalent mass moments of inertia, respectively, in the equations of motion for the rotating Timoshenko shaft carrying arbitrary rigid disks. It is found that the above‐mentioned equations for the rotating 3D shaft‐disk system take the same forms as the corresponding ones for the associated stationary two‐dimensional (2D) Timoshenko beam carrying the same number of disks, so that the approaches for the free vibration analyses of the stationary 2D beam‐disk system can be used to solve the title problem for obtaining the whirling speeds and mode shapes of a rotating 3D shaft‐disk system. Since the order of the eigenproblem equation derived from the presented approach is much smaller than that derived from the conventional finite element method (FEM), the computer time consumed by the former is much less than that by the latter. In addition, the solutions obtained from the presented approach are exact and may be the benchmark for evaluating the accuracy of solutions of the other approximate methods. Numerical examples reveal that the presented approach is available for the uniform or nonuniform shaft‐disk system, and the obtained results are very close to those obtained from existing literature or the FEM. The formulation of this article is available for a shaft‐disk system with various boundary conditions (BCs), to save space, only the cases with pinned‐pinned BCs are illustrated.
Global On Line Fellowship in head and neck surgery and oncology
Authors: Shah Jatin P. , O'Neil James P. , Brennan Murray F. 
Published: July 2020

AbstractThe International Federation of Head and Neck Oncologic Societies and Memorial Sloan Kettering Cancer Center in New York have partnered to create the Global On Line Fellowship program, a postgraduate fellowship training opportunity for candidates all around the world who are not able to get on‐site fellowship training at centers of excellence. This article delineates the successes, challenges, and future goals for the program.
Meso‐Substituted Tetrabenzotriazaporphyrins for Dye‐Sensitized Solar Cells
Authors: Tejerina Lara , Yamamoto Satoshi , López‐Duarte Ismael , Martínez‐Díaz M. Victoria , Kimura Mutsumi , Torres Tomás 
Published: July 2020

AbstractA novel tetrabenzotriazaporphyrin (TBTAP) bearing an anchoring carboxy‐phenyl group at the meso‐carbon position (TT260) was synthesized by an efficient method, which involves the crossover condensation between phthalonitrile and aminoisoindoline precursors. Its optical and electrochemical properties were also investigated together with its use as sensitizer in dye‐sensitized solar cells (DSSCs). The performance of TT260 was compared with a benchmark molecule TT1, bearing similar bulky tert‐butyl groups at the periphery. The device, which is the first ever example of meso‐substituted TBTAP‐based DSSC, exhibits a modest maximum power conversion efficiency of 2.4±0.1 % under one‐sun conditions.
Deep transfer learning based hepatitis B virus diagnosis using spectroscopic images
Authors: Ali Safdar , Hassan Mehdi , Saleem Muhammad , Tahir Syed Fahad 
Published: July 2020

AbstractAccurate identification of Hepatitis B virus (HBV) disease by analyzing the Raman spectroscopic images is a challenge for pathologists. To save precious human lives, an efficient technique is required with higher diagnostic accuracy at early‐stage of HBV. We proposed a novel method of HBV diagnosis using deep neural networks with the concept of transfer learning and Raman spectroscopic images. The proposed approach developed by utilizing pretrained convolutional neural networks ResNet101 by employing transfer learning on a real dataset of HBV‐infected blood plasma samples. Dataset consists of 1000 Raman images in which 600 are HBV‐infected blood plasma samples, and 400 are healthy ones. The developed model is capable to detect minute variation between infected and healthy samples and achieved enhanced performance. The proposed approach has been assessed and attained high classification accuracy, sensitivity, specificity, and AUC of 99.7%, 100%, 99.25%, and 98.7%, respectively. The proposed TL‐ResNet101 model outperformed the conventional approaches such as PCA‐SVM and PCA‐LDA and demonstrated improved accuracy more than 7%. High performance indicates that the developed TL‐ResNet101 model has potential to use for HBV diagnosis. Moreover, the developed automated approach can be extended for other disease.
Antimicrobial efficacy of platinum‐doped silver nanoparticles
Authors: Wongkamhaeng Kan , Wang Junnan , Banas Jeffrey A. , Dawson Deborah V. , Holloway Julie A. , Haes Amanda J. , Denry Isabelle 
Published: July 2020

AbstractSilver nanoparticles (AgNPs) have been proposed to combat oral infection due to their efficient ionic silver (Ag+) release. However, concentrations required for antimicrobial efficacy may not be therapeutically viable. In this work, platinum‐doped silver nanoparticles (Pt‐AgNPs) were explored to evaluate their potential for enhanced Ag+ release, which could lead to enhanced antimicrobial efficacy against S. aureus, P. aeruginosa, and E. coli. AgNPs doped with 0.5, 1, and 2 mol% platinum (Pt0.5‐AgNPs, Pt1‐AgNPs, and Pt2‐AgNPs) were synthesized by a chemical reduction method. Transmission electron microscopy revealed mixed morphologies of spherical, oval, and ribbon‐like nanostructures. Surface‐enhanced Raman scattering revealed that the surface of Pt‐AgNPs was covered with up to 93% Pt. The amount of Ag+ released increased 16.3‐fold for Pt2‐AgNPs, compared to AgNPs. The initial lag phase in bacterial growth curve was prolonged for Pt‐AgNPs. This is consistent with a Ag+ release profile that exhibited an initial burst followed by sustained release. Doping AgNPs with platinum significantly increased the antimicrobial efficacy against all species. Pt2‐AgNPs exhibited the lowest minimum inhibitory concentrations, followed by Pt1‐AgNPs, Pt0.5‐AgNPs, and AgNPs, respectively. Doping AgNPs with a small amount of platinum promoted the release of Ag+, based on the sacrificial anodic effect, and subsequently enhanced their antimicrobial efficacy.
Red blood cell exchange to avoid intubating a COVID‐19 positive patient with sickle cell disease?
Authors: Allison David , Campbell‐Lee Sally , Crane Jason , Vidanovic Vladimir , Webb Shaun , Fraidenburg Dustin , Hussain Faiz 
Published: July 2020

AbstractAs the COVID‐19 pandemic continues to claim lives across the globe, insufficient data exists regarding the optimal treatment. It is well known that patients 55 years of age or older and patients with certain chronic diseases are at higher risk of severe illness, including acute respiratory distress syndrome and death. A potentially fatal pulmonary complication of sickle cell disease, acute chest syndrome, can be precipitated by acute infections, including respiratory viruses. We report the case of a patient with sickle cell disease (HbSC) who developed COVID‐19 pneumonia and acute chest syndrome who was treated with emergent red blood cell exchange in order to avoid endotracheal intubation.
Protective effect of microRNA‐134‐3p on multiple sclerosis through inhibiting PRSS57 and promotion of CD34+ cell proliferation in rats
Authors: Song Qihan , Zhao Fengli , Yao Jingfan , Dai Hailin , Hu Lei , Yu Shun 
Published: July 2020

AbstractMicroRNAs (miRs) have been extensively studied for their involvement in multiple sclerosis (MS). We investigated the involvement of miR‐134‐3p on MS. The MS rat model was established, and positive expression of interleukin‐17 (IL‐17) was detected using the immunohistochemical method while the expression of miR‐134‐3p and serine protease 57 (PRSS57) was determined by means of reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and Western blot analysis. Second, the miR‐134‐3p overexpression or short hairpin RNA against PRSS57 was introduced into the CD34+ cells to investigate the levels of proliferation and apoptosis‐related genes by RT‐qPCR and Western blot analysis. In addition, analysis of the targeting relations of miR‐134‐3p and PRSS57 was conducted using online software and dual‐luciferase reporter gene assay. Furthermore, neuronal functions, inflammatory response, proliferation, and apoptosis of CD34+ cells were assayed by flow cytometry, enzyme‐linked immunosorbent assay, and methyl thiazolyl tetrazolium. IL‐17 and PRSS57 expression increased while miR‐134‐3p expression decreased in the spinal cord from MS rats. miR‐134‐3p could target PRSS57. miR‐134‐3p overexpression or PRSS57 silencing enhanced mitochondrial activity of neurons, mitochondrial membrane potential content, CD34+ cell proliferation, while decreasing Cyt C content, inflammatory response, and cell apoptosis. Collectively, overexpression of miR‐134‐3p promotes CD34+ cell proliferation via inhibition of PRSS57 in MS, which may serve as a promising target for MS intervention.
Hypermethylation of lncRNA MEG3 impairs chemosensitivity of breast cancer cells
Authors: Li Hongchang , Wang Puhua , Liu Jiazhe , Liu Weiyan , Wu Xubo , Ding Junbin , Kang Jie , Li Jindong , Lu Jingfeng , Pan Gaofeng 
Published: July 2020

AbstractBackgroundChemoresistance posed a barrier to successful treatment of breast cancer (BC), and lncRNA MEG3 has been documented to implicate in BC development. However, whether MEG3 methylation, which led to low MEG3 expression, was relevant to BC progression and chemoresistance remained uncertain.MethodsIn the aggregate, 374 pairs of tumor tissues and adjacent normal tissues were collected from pathologically confirmed BC patients, and four BC cell lines, including MDA‐MB‐231, Bcap‐37, MCF‐7, and SK‐BR‐3, were purchased. Moreover, methylation‐specific polymerase chain reaction (PCR) was adopted to evaluate the methylation status of BC tissues and cell lines, and chemo‐tolerance of BC cell lines was assessed by performing MTT assay. Concurrently, transwell assay and scratch assay were carried out to estimate the migratory and invasive capability of BC cell lines.ResultsMethylated MEG3, lowly expressed MEG3, large tumor size (≥2 cm), advanced TNM grade and lymphatic metastasis were potentially symbolic of poor prognosis among BC patients (P < .05). Besides, MDA‐MB‐231 cell line exhibited the strongest resistance against paclitaxel, adriamycin, and vinorelbine (P < .05), while MCF‐7 cell line seemed more sensitive against these drugs than any other BC cell line (P < .05). Furthermore, pcDNA3.1‐MEG3 and 5‐Aza‐dC markedly sensitized MDA‐MB‐231 and MCF‐7 cell lines against the drug treatments (P < .05). Simultaneously, proliferation and metastasis of the BC cell lines were slowed down under the force of pcDNA3.1‐MEG3 and 5‐Aza‐dC (P < .05).ConclusionPreventing methylation of MEG3 might matter in lessening BC chemoresistance, owing to its hindering proliferation and metastasis of BC cells.