bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review
Authors: Koidou Vasiliki P. , Cavalli Nicolo , Hagi‐Pavli Eleni , Nibali Luigi , Donos Nikolaos 
Published: August 2020

AbstractBackgroundNon‐surgical periodontal treatment (NSPT) is widely employed for the treatment of periodontal disease and yields significant clinical improvements. Gingival crevicular fluid (GCF) can be used to profile health and disease, and recent technological advances, such as multiplex bead immunoassays, are promising in identifying a wider array of GCF factors with the ultimate aim to predict the treatment response.ObjectiveThe aim of this systematic review was to compare the expression of GCF markers using multiplex bead immunoassays before treatment and during early, average, or late healing period, following non‐surgical periodontal treatment (NSPT).MethodsAn electronic literature search was conducted by two independent examiners (VK and NC) in MEDLINE, EMBASE, OpenGrey, LILACS, and Cochrane Library up to January 2020. The PICO question formulated was as follows: “In patients with periodontal disease, does the expression of gingival crevicular fluid (GCF) markers detected using multiplex bead immunoassay differ at baseline compared with early (≤30 days), average (6‐8 weeks), or late (≥3 months) healing after intervention?”ResultsA total of 366 publications were obtained and reviewed for eligibility for inclusion. Of these, 12 publications fulfilled the inclusion criteria and were included in the present review. Data for a total of 31 different GCF markers were extracted and summarized for early, average, or late healing after NSPT. Early healing following NSPT (≤ 30 days) indicated an increase in IL‐1β, TNFα, and IL‐10. At the average healing period (6‐8 weeks), IL‐1β, IL‐1α, IL‐6, TNF‐α, IFN‐γ, GM‐CSF, MCP‐1, and MIP‐1α were all reduced, compared to their respective baseline values. Three months after NSPT, IL‐1β, IL‐4, IL‐6, IL‐10, TNF‐α, and IFN‐γ were detected at reduced levels, compared to pre‐treatment levels. Overall, the changes following treatment indicated a reduction of inflammation present at baseline.ConclusionFollowing non‐surgical periodontal treatment, an upregulation of inflammation markers is noted early post‐operatively and a subsequent reduction of their levels three months following treatment. The investigation of levels of GCF markers associated with inflammation and regeneration, especially using multiplex bead immunoassay technologies, is a valuable tool to better understand the processes associated with healing following periodontal treatment.
Growth and physiological responses of juvenile amberjack (Seriola dumerili) fed pellet diets bound by different binders
Authors: Yokoyama Saichiro , Asada Yuya , Ishikawa Manabu , Koshio Shunsuke 
Published: August 2020

AbstractAppropriate binders have not yet been determined in pellet feed for amberjack Seriola dumerili juveniles. This study aimed to assess the influence of binders (activated gluten [AG], guar gum [GG], and carboxymethylcellulose [CMC]) on growth, feed ingestion, gastric emptying time (GET), digestibility, intestinal histology, body composition, and blood chemical constituents of amberjack juvenile. Dry pellets bound by supplementing different binders (3% AG, 2.5% AG combined with 0.5% GG [AG + GG], and 3% CMC) were fed to fish (mean body weight ± SD = 52.5 ± 0.6 g) for 30 days. After feeding, fish fed the AG diet exhibited growth, protein and dry matter digestibility, and feed utilization levels significantly (p < .05) higher than those of fish fed the AG + GG and CMC diets. Moreover, GET in fish fed the AG + GG and CMC diets were slower than those from fish in the AG group. These responses appeared to be associated with the viscosity of binders and diets. In fish fed the AG + GG and CMC diets, several blood indices were significantly (p < .05) lower than those in fish fed the AG diet. These results suggest that AG is a candidate binder in pellet feed for amberjack juvenile.
Knowledge distance and R&D collaboration in Cournot oligopoly
Authors: Caminati Mauro 
Published: August 2020

AbstractA Cournot collaboration game is complemented with the hypothesis that the cost of R&D collaboration depends on firm’s directed knowledge distance with respect to potential R&D partners. The further hypothesis that directed distance may be non‐uniform and pair‐wise asymmetric reconciles theoretical predictions with qualitative evidence about concentration and multiplicity of components in industrial R&D networks. The welfare properties of sparse stable networks are also affected.
Bowen Family Systems Theory: Mapping a framework to support critical care nurses’ well‐being and care quality
Authors: Jakimowicz Samantha , Perry Lin , Lewis Joanne 
Published: August 2020

AbstractIntensive care nursing is prone to episodic anxiety linked to patients’ immediate needs for treatment. Balancing biomedical interventions with compassionate patient‐centred nursing can be particularly anxiety provoking. These patterns of anxiety may impact compassion and patient‐centred nursing. The aim of this paper is to discuss the application of Bowen Family Systems Theory to intensive care nursing, mapping a framework to support critical care nurses’ well‐being and, consequently, the quality of care they provide. This article is founded on research, theoretical papers and texts focused on Bowen Family Systems Theory (BFST), and findings from a constructivist study on patient‐centred nursing and compassion in the intensive care unit. The goal of Bowen Family Systems Theory is to empower individuals, decreasing blame and reactivity. Bowen Family Systems Theory can be applied to the sometimes intimate relationships that develop in this environment, aiding understanding of nurses’ experience of compassion satisfaction and fatigue. Where organizational factors and management styles fall short in supporting critical care nurses to meet expectations, BFST can offer a perspective on the processes that occur within the intensive care unit, impacting nurse well‐being and quality of care. This paper makes plain the importance of understanding the anxiety that occurs within the intensive care unit as a system, so that individuals, such as critical care nurses, can be supported appropriately to ensure nurse well‐being and quality care.
Controlling child feeding practices and child weight: A systematic review and meta‐analysis
Authors: Ruzicka Elizabeth B. , Darling Katherine E. , Sato Amy F. 
Published: August 2020

SummaryControlling child feeding practices (restriction and pressure‐to‐eat) have been theorized to predict increased child weight status. However, mixed evidence has been found for this association within previous narrative reviews. The present study quantitatively examined the association between controlling feeding practices and child weight status and examine potential study‐level and person‐level moderators. PubMed, PsychINFO, and Cochrane databases were utilized. Studies examining the association of controlling child feeding practices and child weight were included. Data from 51 studies, with 17 431 parent‐child dyads, were included. There was a small but significant association between restrictive child feeding practices and child weight (d = .22, 95% CI, .14 to .30). Restriction was significantly associated with higher child weight status. This association was significantly moderated by child age and household income. There was also a significant association between pressure‐to‐eat child feeding practices and child weight (d = −.30, 95% CI, −.38 to −.22). No significant moderators were identified. Pressure‐to‐eat was significantly associated with lower child weight status. There was a high degree of heterogeneity of effects between studies included in analyses. Longitudinal studies are needed to examine the effect of controlling feeding on child weight over time.
Putrescine elicits ROS‐dependent activation of the salicylic acid pathway in Arabidopsis thaliana
Authors: Liu Changxin , Atanasov Kostadin E. , Arafaty Nazanin , Murillo Ester , Tiburcio Antonio F. , Zeier Jürgen , Alcázar Rubén 
Published: August 2020

AbstractPolyamines are small amines that accumulate during stress and contribute to disease resistance through as yet unknown signaling pathways. Using a comprehensive RNA‐sequencing analysis, we show that early transcriptional responses triggered by each of the most abundant polyamines (putrescine, spermidine, spermine, thermospermine and cadaverine) exhibit specific quantitative differences, suggesting that polyamines (rather than downstream metabolites) elicit defense responses. Signaling by putrescine, which accumulates in response to bacteria that trigger effector triggered immunity (ETI) and systemic acquired resistance (SAR), is largely dependent on the accumulation of hydrogen peroxide, and is partly dependent on salicylic acid (SA), the expression of ENHANCED DISEASE SUSCEPTIBILITY (EDS1) and NONEXPRESSOR of PR GENES1 (NPR1). Putrescine elicits local SA accumulation as well as local and systemic transcriptional reprogramming that overlaps with SAR. Loss‐of‐function mutations in arginine decarboxylase 2 (ADC2), which is required for putrescine synthesis and copper amine oxidase (CuAO), which is involved in putrescine oxidation, compromise basal defenses, as well as putrescine and pathogen‐triggered systemic resistance. These findings confirm that putrescine elicits ROS‐dependent SA pathways in the activation of plant defenses.
Confucianism and Daoism: On the relationship between theAnalects,Laozi, andZhuangzi, Part I
Authors: D'Ambrosio Paul J. 
Published: August 2020

AbstractTheLunyu論語 (Analectsof Confucius),Daodejing道德經 (Classic of the Way and Virtuosity) orLaozi老子 (Book of Master Lao), and theZhuangzi莊子 (Book of Master Zhuang) have been broadly classified as representative of Confucianism (Lunyu) and Daoism (LaoziandZhuangzi). This loose grouping, and the similarities and differences associated with these “schools” include some of the most telling and simultaneously misleading generalizations about Chinese philosophy or thought in general. These articles seek to provide an overview of the relationship between Confucianism and Daoism. The first article begins before with a generalized topics based comparison of the Lunyu,LaoziandZhuangzi. The latter two texts include their own significant differences, but I will, wherever possible, look for generalities that fit both. The major themes considered in this first part are (1) the perspectives on names (ming 名) and actualities (shi 實), (2) cultivation, learning, and what is considered natural (ziran 自然), and finally (3) conceptions of the person.
Fatigue‐induced change in T‐system excitability and its major cause in rat fast‐twitch skeletal muscle in vivo
Authors: Watanabe Daiki , Wada Masanobu 
Published: August 2020

Key points
Using mechanically skinned rat muscle fibres, we investigated (i) transverse tubular‐system (T‐system) excitability after high‐intensity contractions, and (ii) the mechanisms underlying the fatigue‐induced alteration of the T‐system excitability.
T‐system excitability estimated by using skinned fibres, which is highly regulated by T‐system Na+‐K+‐ATPase, was decreased after muscle contractions, but was fully restored by treatment with dithiothreitol.
The S‐glutathionylation of Na+–K+‐ATPase in whole muscle was increased after muscle contractions and also occurred under very low ATP conditions in rested but not stimulated fibres.
In conclusion, T‐system excitability was decreased after high‐intensity exercise due at least in part to the S‐glutathionylation of Na+–K+‐ATPase, which may be enhanced by contraction‐induced ATP depression.
AbstractThe purpose of this study was to investigate transverse tubular system (T‐system) excitability after skeletal muscle contractions in vivo, and the contribution of S‐glutathionylation of Na+–K+‐ATPase. T‐system excitability was estimated by measuring the repriming period (RP) required for double action potentials in mechanically skinned fibres where the sarcolemma was removed but the T‐system still functioned. The RP under partially depolarized conditions was highly dependent on the function of Na+–K+‐ATPase. Rat gastrocnemius (GAS) muscles were subjected to repetitive contractions until the force was decreased to ∼50% of initial force, and then the muscles were very quickly excised and used for skinned fibre and biochemical experiments. The RP under partially depolarized conditions was increased in stimulated fibres (5.9 ± 1.0 ms in rested vs. 8.0 ± 1.5 ms in stimulated); however, this increase in RP was reversed by sequential treatment with dithiothreitol. The skinned fibres from rested muscles exhibited slower repriming only when treated with oxidized glutathione (GSSG) under very low ATP (≤1 mm) conditions, whereas the RP in stimulated fibres was not altered after GSSG treatment without ATP. In line with this, the α2‐ and β‐subunits of Na+–K+‐ATPase were more S‐glutathionylated in stimulated than in rested muscles. These results suggest that (i) T‐system excitability is decreased during contractions, in part due to a downregulation of T‐system Na+–K+‐ATPase, (ii) S‐glutathionylation contributes to the fatigue‐induced decline of the T‐system Na+–K+‐ATPase function, and (iii) ATP depression throughout contractions may enhance S‐glutathionylation of T‐system Na+–K+‐ATPase.
Fiber Crimp Confers Matrix Mechanical Nonlinearity, Regulates Endothelial Cell Mechanosensing, and Promotes Microvascular Network Formation
Authors: Davidson Christopher D. , Jayco Danica Kristen P. , Wang William Y. , Shikanov Ariella , Baker Brendon M. 
Published: August 2020

Abstract
Mechanical interactions between cells and their surrounding extracellular matrix (ECM) guide many fundamental cell behaviors. Native connective tissue consists of highly organized, 3D networks of ECM fibers with complex, nonlinear mechanical properties. The most abundant stromal matrix component is fibrillar type I collagen, which often possesses a wavy, crimped morphology that confers strain- and load-dependent nonlinear mechanical behavior. Here, we established a new and simple method for engineering electrospun fibrous matrices composed of dextran vinyl sulfone (DexVS) with controllable crimped structure. A hydrophilic peptide was functionalized to DexVS matrices to trigger swelling of individual hydrogel fibers, resulting in crimped microstructure due to the fixed anchorage of fibers. Mechanical characterization of these matrices under tension confirmed orthogonal control over nonlinear stress–strain responses and matrix stiffness. We next examined ECM mechanosensing of individual endothelial cells (ECs) and found that fiber crimp promoted physical matrix remodeling alongside decreases in cell spreading, focal adhesion area, and nuclear localization of Yes-associated protein (YAP). These changes corresponded to an increase in migration speed, along with evidence for long-range interactions between neighboring cells in crimped matrices. Interestingly, when ECs were seeded at high density in crimped matrices, capillary-like networks rapidly assembled and contained tube-like cellular structures wrapped around bundles of synthetic matrix fibers due to increased physical reorganization of matrix fibers. Our work provides an additional level of mechanical and architectural tunability to synthetic fibrous matrices and implicates a critical role for mechanical nonlinearity in EC mechanosensing and network formation.
A Post-COVID-19 Lifestyle Sport Research Agenda: Communication, Risk, and Organizational Challenges
Authors: Smith William Roth 
Published: August 2020

The cancellations and postponements of large-scale organized sport competitions provided the first indicators of the impact that COVID-19 would have on society. During the pandemic, sport media reporting has focused on cancellations. Although not receiving as much media attention, “lifestyle sports,” such as rock climbing, parkour, BMX, kayaking, or skateboarding, were also impacted by COVID-19 in ways that differ from organized team sports. In this commentary, the author draws upon select media reports and subcultural social media posts to highlight two primary impacts of COVID-19: (a) the civic organizational challenges of limiting lifestyle sport participation and (b) the influence on the social and risk-laden experience of these sports. The article concludes by detailing lifestyle sport stakeholder communication, digital sporting communities, the use of social media for organizing lifestyle sport communities, and sport risk communication as fruitful avenues for future research in a postpandemic lifestyle sports.
Can Treadmill Slip-Perturbation Training Reduce Longer-Term Fall Risk Upon Overground Slip Exposure?
Authors: Lee Anna , Bhatt Tanvi , Liu Xuan , Wang Yiru , Wang Shuaijie , Pai Yi-Chung (Clive) 
Published: August 2020

The purpose was to examine and compare the longer-term generalization between 2 different practice dosages for a single-session treadmill slip-perturbation training when reexposed to an overground slip 6 months later. A total of 45 older adults were conveniently assigned to either 24 or 40 slip-like treadmill perturbation trials or a third control group. Overground slips were given immediately after initial training, and at 6 months after initial training in order to examine immediate and longer-term effects. The performance (center of mass stability and vertical limb support) and fall percentage from the laboratory-induced overground slips (at initial posttraining and at 6 mo) were measured and compared between groups. Both treadmill slip-perturbation groups showed immediate generalization at the initial posttraining test and longer-term generalization at the 6-month retest. The higher-practice-dosage group performed significantly better than the control group (P < .05), with no difference between the lower-practice-dosage and the control groups at the 6-month retest (P > .05). A single session of treadmill slip-perturbation training showed a positive effect for reducing older adults’ fall risk for laboratory-induced overground slips. A higher-practice dosage of treadmill slip perturbations could be more beneficial for further reducing fall risk.
Rapid expansion of meso-megathermal rain forests into the southern high latitudes at the onset of the Paleocene-Eocene Thermal Maximum
Authors: Huurdeman E.P. , Frieling J. , Reichgelt T. , Bijl P.K. , Bohaty S.M. , Holdgate G.R. , Gallagher S.J. , Peterse F. , Greenwood D.R. , Pross J. 
Published: August 2020

Abstract
Current knowledge of terrestrial ecosystem response to the Paleocene-Eocene Thermal Maximum (PETM; ca. 56 Ma) is largely based on the midlatitudes of the Northern Hemisphere. To more fully reconstruct global terrestrial ecosystem response to the PETM, we generated vegetation and biomarker proxy records from an outcrop section on the southern coast of Australia (∼60°S paleolatitude). We documented a rapid, massive, and sustained vegetation turnover as a response to regional PETM warming of ∼1–4 °C, abruptly transitioning from a warm temperate to a meso-megathermal rain forest similar to that of present-day northeastern Queensland, Australia. The onset of this vegetation change preceded the characteristic PETM carbon-isotope excursion (CIE) by several thousand years. The reconstructed ecosystem change is much stronger than in other Southern Hemisphere records, highlighting the need for consideration of regional paleoceanographic, paleogeographic, and biogeographic characteristics to fully understand the global terrestrial ecosystem response to PETM climate forcing.
Negligible surface uplift following foundering of thickened central Tibetan lower crust
Authors: Zeng Yunchuan , Ducea Mihai N. , Xu Jifeng , Chen Jianlin , Dong Yan-Hui 
Published: August 2020

AbstractThis study used clinopyroxene (cpx) compositions and zircon Hf-O isotopes of Eocene adakitic rocks (EARs) from the Qiangtang block to resolve the mechanism(s) responsible for the formation of the central Tibetan Plateau. The two leading and opposing hypotheses for the origin of these rocks are (1) partially molten foundered lower crust, and (2) partial melting of continentally subducted upper crust. The consensus is that some crustal sources within the mantle have reached eclogite facies, while evidence remains insufficient. Reverse zonation for cpx in high Mg# andesitic samples shows a low Mg# core with lower Sr and Sr/Y than the high Mg# rim, suggesting derivation of parent magma by interaction between some eclogite-derived felsic melts and mantle peridotite. Overall, the mantle-like zircon δ18O (mean value of ∼5.9‰) and εHf(t) (up to +6.7) values argue for a mafic source rather than buried upper-crustal rocks. Given the EARs were formed within a short time span after the end of crustal shortening, the original felsic melts were most likely derived from the foundered and eclogitized lower crust. The foundering process explains the early Eocene low-relief topography and the intermediate, eclogite-free modern crustal composition of central Tibet. Surface uplift as a response to lithosphere removal, however, was likely negligible, based on various lines of evidence, including sediment provenance, isotope paleoaltimetry, and thermochronology, perhaps because the central Tibetan crust was weak.
Formation of the First Bend in the late Eocene gave birth to the modern Yangtze River, China
Authors: Zheng Hongbo , Clift Peter D. , He Mengying , Bian Zixuan , Liu Gaozheng , Liu Xiaochun , Xia Lei , Yang Qing , Jourdan Fred 
Published: August 2020

AbstractThe First Bend on the Yangtze River (China), the point where the river ceases flowing toward the south and heads toward the northeast, has been one of the most strongly debated geomorphic features in Asia because it holds the key to understanding the history of the Yangtze River and is linked to the tectonically driven surface uplift of the southeastern Tibetan Plateau. Mid- to upper Eocene sedimentary rocks preserved in the Jianchuan Basin located immediately southwest of the First Bend demonstrate that a large river system, presumably the paleo–Jinshajiang River (the upper Yangtze), used to flow south through that region. Provenance analysis of sediments over the wider region, based mostly on U-Pb dating of detrital zircon grains, confirms that the once south-flowing paleo–Yangtze River originated in the Tibetan Plateau and flowed into the South China Sea. Inversion of the Jianchuan Basin, starting in or after the latest Eocene and associated with wider plateau surface uplift at that time, caused the river to be diverted toward the northeast where it was confined along tectonic lineaments associated with strike-slip faulting, giving birth to the First Bend, a major step in the formation of the modern Yangtze River.