bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergies of river and land circulation in towns with small rivers: The case of Poitiers (France)
Authors: Gorin Camille 
Published: January 2021

AbstractThe development of waterfront archeology since the 1970s has motivated the study of the synergies between cities and rivers. The increasing number of excavations in city waterfronts with its inception in Northern Europe, emphasize the complexity and value of riparian areas. These city‐river synergies shed light on such natural and cultural complexity, which requires a multidisciplinary approach and highlights the dynamics of a changing, hybrid and multifunctional riverine area. Although this interdisciplinary field of research has recently been growing, archeological research in France is focused primarily on large hydro systems with respect to smaller ones. This paper focuses on two secondary watercourses—the Clain and the Boivre—surrounding the city of Poitiers in Western France. Studying river and land circulation of the city in a longue durée perspective highlights the importance of small rivers in waterway traffic, as well as their archeological potential. These findings call for a reconsideration of the rich heritage of small rivers in future urban development projects, taking into account the sensitivity of small hydro systems to environmental changes.This article is categorized under:
Human Water > Human Water
Priorisierung intensivmedizinischer Behandlungsplätze – Konzeptvorschlag
Authors: Deppe A. C. , Kolibay F. , Burst V. , Simon S. , Rothschild M. , Kochanek M. , Annecke T. , Adler C. , Dusse F. , Hof M. , Langebartels G. , Reimers S. , Muckel S. , Roth B. , Wolff J. , Onur O. A. 
Published: January 2021

ZusammenfassungIn der Situation des Beatmungsbettenmangels sind ethisch begründbare, transparente und nachvollziehbare Entscheidungen zu treffen. Dieses Konzept sieht vor, dass zunächst alle Patienten nach Notwendigkeit intubiert und dann von einem Triage-Team beurteilt werden. Dabei stehen neu aufgenommene COVID-Patienten mit neu aufgenommenen Nicht-COVID-Patienten und bereits intensivmedizinisch behandelte Patienten in Konkurrenz um ein Beatmungsgerät. Die Kombination der kurz- und langfristigen Prognose soll dem interprofessionellen Triage-Team ermöglichen, nachvollziehbare Entscheidungen zu treffen. Ziel des Priorisierungskonzeptes ist es, möglichst viele Menschenleben zu retten und die Behandlungsteams von der schwierigen Entscheidung der Priorisierung zu entlasten.
Criminal victimization, cognitive social capital and mental health in an urban region in Germany: a path analysis
Authors: Kilian Reinhold , Müller-Stierlin Annabel , Lamp Natalie , von Gottberg Carolin , Becker Thomas 
Published: January 2021

Abstract
Purpose
There is ample evidence that experiencing a criminal victimization is associated with lasting emotional problems among victims. To date, the mechanisms behind this association are not well understood. Based on the theoretical assumptions derived from a transactional stress-appraisal and coping model this study analyses the role of cognitive social capital (SC) in the association between criminal victimization (CV) and victims’ mental health.

Methods
A cross-sectional, computer-aided telephone survey including a representative sample of 3005 persons from three German cities was conducted. Respondents were asked about CV during their lifetime, cognitive SC, perceived victimization risk, perceived safety and perceived ability to prevent victimization. The PHQ-4 was used as a measure of anxiety and depression. The data were analyzed by means of logistic regression models and a path model controlled for sociodemographic characteristics.

Results
Lifetime CV with any type of crime was associated with a clinically relevant increased risk of mental disorder (PHQ-4 ≥ 9; OR 1.8, p ≤ 0.05). Path analyses revealed that the direct association between CV and PHQ-4 (β = 0.454; p ≤ 0.01) was significantly diminished by cognitive SC (β =  − 0.373; p ≤ 0.05).

Conclusion
Our results suggest that cognitive SC is an individual resilience factor against negative experiences related to CV and that it holds the potential to diminish negative mental health consequences of CV. Further research should explore to what extent an enhancement of cognitive SC can help to prevent anxiety and depression among crime victims.
UB-H: an unbalanced-hierarchical layer binary-wise construction method for high-dimensional data
Authors: Ihm Sun-Young , Park So-Hyun , Park Young-Ho 
Published: January 2021

AbstractCloud computing, which is distributed, stored and managed, is drawing attention as data generation and storage volumes increase. In addition, research on green computing, which increases energy efficiency, is also widely studied. An index is constructed to retrieve huge dataset efficiently, and the layer-based indexing methods are widely used for efficient query processing. These methods construct a list of layers, so that only one layer is required for information retrieval instead of the entire dataset. The existing layer-based methods construct the layers using a convex hull algorithm. However, the execution time of this method is very high, especially in large, high-dimensional datasets. Furthermore, if the total number of layers increases, the query processing time also increases, resulting in efficient, but slow, query processing. In this paper, we propose an unbalanced-hierarchical layer method, which hierarchically divides the dimensions of input data to increase the total number of layers and reduce the index building time. We demonstrate that the proposed procedure significantly increases the total number of layers and reduces the index building time, compared to existing methods through the various experiments.
Traumatic open globe injury—epidemiology, risk factors and visual outcome at the University Hospital Aachen
Authors: Djalali-Talab Yassamin , Mazinani Babac , Djalali-Talab Yassin 
Published: January 2021

Summary
Background
Ocular trauma is still a major cause leading to enucleation. This study aims to analyze the visual outcome, epidemiology and risk factors of open globe injury (OGI) at the University Hospital Aachen, Germany.

Material and methods
A retrospective analysis of patient records involving traumatic OGI treated surgically between 2005 and 2015 was conducted. Age, gender, cause of accident, ocular trauma score, best corrected visual acuity (BCVA) at presentation and after treatment as well as location of injury were evaluated.

Results
Of 2272 eyes with trauma, 102 patients with OGI were identified, of which 65% were male and 35% were female. Women were significantly older than men (p < 0.001). The most common cause of injury was domestic syncopal episodes (47%). Work-related injuries occurred exclusively in men in 8.8%. A total of 16% had no light perception (NLP) at presentation, 69% of which improved post intervention to hand movement or better. Endophthalmitis was observed in 4% of all cases. Enucleation was needed mostly due to rupture. Location of OGI, pseudophakia and initial BCVA are risk factors for poor final BCVA. Patients’ BCVA did not improve further after three surgeries.

Conclusion
Traumatic OGI still poses a challenge in terms of treatment planning and prognostic outcome. A rise in elderly patients with multimorbidity represents a secondary obstacle to treatment. Patients with initial NLP can be treated with moderate success. Nevertheless, risk factors and ocular trauma score are unable to provide definitive therapy decisions. OGI should be assessed case by case, taking risk factors for OGI into account. Treating physicians should consider the ethical and economic reasons with regard to whether a high number of surgeries with possible comorbidities is justified.
Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?
Authors: Samuel Sabrina F. , Barry Antonia , Greenman John , Beltran-Alvarez Pedro 
Published: January 2021

AbstractDespite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16 months after diagnosis, on average. Inhibitors of protein arginine methyltransferases (PRMTs) have been developed and investigated over the past 15 years and have now entered oncology clinical trials, including for brain tumours. This review collates recent advances in the understanding of the role of PRMTs and arginine methylation in brain tumours. We provide an up-to-date literature review on the mechanisms for PRMT regulation. These include endogenous modulators such as alternative splicing, miRNA, post-translational modifications and PRMT–protein interactions, and synthetic inhibitors. We discuss the relevance of PRMTs in brain tumours with a particular focus on PRMT1, -2, -5 and -8. Finally, we include a future perspective where we discuss possible routes for further research on arginine methylation and on the use of PRMT inhibitors in the context of brain tumours.
Hardware Failure Prediction on Imbalanced Times Series Data
Authors: Rücker Nadine , Pflüger Lea , Maier Andreas 
Published: January 2021

AbstractMagnetic resonance imaging (MRI) systems and their continuous, failure-free operation is crucial for high-quality diagnostics and seamless workflows. One important hardware component is coils as they detect the magnetic signal. Before every MRI scan, several image features are captured which represent the used coil’s condition. These image features recorded over time are used to train machine learning models for classification of coils into normal and broken coils for faster and easier maintenance. The state-of-the-art techniques for classification of time series involve different kinds of neural networks. We leveraged sequential data and trained three models, long short-term memory (LSTM), fully convolutional network (FCN), and the combination of those called LSTMFCN as reported by Karim et al. (IEEE access6:1662–1669, 2017). We found LSTMFCN to combine the benefits of LSTM and FCN. Thus, we achieved the highest F1-score of 87.45% and the highest accuracy of 99.35% using LSTMFCN. Furthermore, we tackled the high data imbalance of only 2.1% data collected from broken coils by training a Gaussian process (GP) regressor and adding predicted sequences as artificial samples to our broken labelled data. Adding 40 synthetic samples increased the classification results of LSTMFCN to an F1-score of 92.30% and accuracy of 99.83%. Thus, MRI head/neck coils can be classified normal or broken by training a LSTMFCN on image features, successfully. Augmenting the data using GP-generated samples can improve the performance even further.
Clinical value of digital tomographic fusion imaging in the diagnosis of avascular necrosis of the femoral head in adults
Authors: Zhang Jiangang , Wang Zhuhai , Hong Ge 
Published: January 2021

Abstract
Background
To explore the clinical significance of digital tomographic fusion imaging in the diagnosis of avascular disease of the femoral head in adults.

Methods
Eighty-two adult patients with avascular necrosis of the femoral head confirmed by MRI in the department of orthopedics of our hospital were studied retrospectively. The related signs of adult avascular necrosis of the femoral head were diagnosed by digital tomographic fusion imaging, and the detection rates of digital X-ray (DR) and digital tomosynthesis (DTS) were compared to clarify the clinical value of digital tomographic fusion imaging in the diagnosis of adult avascular necrosis of the femoral head.

Results
DTS detected DR and 78 cases identified 55 cases. Taking the results of CT/MRI as the gold standard, the sensitivity, specificity, positive predictive value, and negative predictive value of DR and DTS in the diagnosis of ANFH were calculated. There was a significant difference in the detection rate between the two methods (P < 0.05).

Conclusion
The digital tomographic fusion imaging technique has the advantages of high detection rate and excellent image quality, is economical, and is worth popularizing. For those with negative X-rays, DTS diagnosis and CT or/and MRI can avoid unnecessary CT and MRI examinations, which is helpful to reduce the waste of medical resources.
Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells
Authors: Feng Jia , Xu Haichan , Cinquina Andrew , Wu Zehua , Chen Qi , Zhang Ping , Wang Xingen , Shan Huiming , Xu Lei , Zhang Qian , Sun Lihua , Zhang Wenli , Pinz Kevin G. , Wada Masayuki , Jiang Xun , Hanes William M , Ma Yupo , Zhang Hongyu 
Published: January 2021

AbstractWhile treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies for T-cell malignancies have been limited. Additionally, T-cell leukemias and lymphomas can commonly metastasize to the CNS, where outcomes are poor and treatment options are associated with severe side effects. Consequently, the development of safer and more effective alternatives for targeting malignant T cells that have invaded the CNS remains clinically important. CD5 CAR has previously been shown to effectively target various T-cell cancers in preclinical studies. As IL-15 strengthens the anti-tumor response, we have modified CD5 CAR to secrete an IL-15/IL-15sushi complex. In a Phase I clinical trial, these CD5-IL15/IL15sushi CAR T cells were tested for safety and efficacy in a patient with refractory T-LBL with CNS infiltration. CD5-IL15/IL15sushi CAR T cells were able to rapidly ablate the CNS lymphoblasts within a few weeks, resulting in the remission of the patient’s lymphoma. Despite the presence of CD5 on normal T cells, the patient only experienced a brief, transient T-cell aplasia. These results suggest that CD5-IL15/IL15sushi CAR T cells may be a safe and useful treatment of T-cell malignancies and may be particularly beneficial for patients with CNS involvement.Graphical Abstract
New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice
Authors: Froghi Saied , Grant Charlotte R. , Tandon Radhika , Quaglia Alberto , Davidson Brian , Fuller Barry 
Published: January 2021

AbstractCalcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells is store-operated calcium entry (SOCE), which occurs via calcium release-activated channels (CRACs). SOCE is central to the activation of immune system cells; however, more recent studies have demonstrated the crucial role of other calcium channels, including transient receptor potential (TRP) channels. In this review, we describe the expression and function of TRP channels within the immune system and outline associations with murine models of disease and human conditions. Therefore, highlighting the importance of TRP channels in disease and reviewing potential. The TRP channel family is significant, and its members have a continually growing number of cellular processes. Within the immune system, TRP channels are involved in a diverse range of functions including T and B cell receptor signalling and activation, antigen presentation by dendritic cells, neutrophil and macrophage bactericidal activity, and mast cell degranulation. Not surprisingly, these channels have been linked to many pathological conditions such as inflammatory bowel disease, chronic fatigue syndrome and myalgic encephalomyelitis, atherosclerosis, hypertension and atopy.
Explanations of variability in Middle Stone Age stone tool assemblage composition and raw material use in Eastern Africa
Authors: Blinkhorn J. , Grove M. 
Published: January 2021

AbstractThe Middle Stone Age (MSA) corresponds to a critical phase in human evolution, overlapping with the earliest emergence of Homo sapiens as well as the expansions of these populations across and beyond Africa. Within the context of growing recognition for a complex and structured population history across the continent, Eastern Africa remains a critical region to explore patterns of behavioural variability due to the large number of well-dated archaeological assemblages compared to other regions. Quantitative studies of the Eastern African MSA record have indicated patterns of behavioural variation across space, time and from different environmental contexts. Here, we examine the nature of these patterns through the use of matrix correlation statistics, exploring whether differences in assemblage composition and raw material use correlate to differences between one another, assemblage age, distance in space, and the geographic and environmental characteristics of the landscapes surrounding MSA sites. Assemblage composition and raw material use correlate most strongly with one another, with site type as well as geographic and environmental variables also identified as having significant correlations to the former, and distance in time and space correlating more strongly with the latter. By combining time and space into a single variable, we are able to show the strong relationship this has with differences in stone tool assemblage composition and raw material use, with significance for exploring the impacts of processes of cultural inheritance on variability in the MSA. A significant, independent role for terrain roughness for explaining variability in stone tool assemblages highlights the importance of considering the impacts of mobility on structuring the archaeological record of the MSA of Eastern Africa.
Characterisation of charred organic matter in micromorphological thin sections by means of Raman spectroscopy
Authors: Lambrecht Glenn , Rodríguez de Vera Caterina , Jambrina-Enríquez Margarita , Crevecoeur Isabelle , Gonzalez-Urquijo Jesus , Lazuen Talía , Monnier Gilliane , Pajović Goran , Tostevin Gilbert , Mallol Carolina 
Published: January 2021

AbstractBurned or charred organic matter in anthropogenic combustion features may provide important clues about past human activities related to fire. To interpret archaeological hearths, a correct identification of the organic source material is key. In the present work, Raman spectroscopy is applied to characterise the structural properties of char produced in laboratory heating- and open-fire experiments. This reference data set is compared to analyses of three different archaeological sites with Middle Palaeolithic combustion contexts. The results show that it is possible to determine whether a charred fragment is the product of burning animal-derived matter (e.g. meat) or plant-derived matter (e.g. wood) by plotting a few Raman spectral parameters (i.e. position of G and D bands, and intensity ratios HD/HG and HV/HG) against one another. The most effective parameters for discriminating animal- from plant-derived matter are the position of the G band and the HV/HG intensity ratio. This method can be applied on raw sample material and on uncovered micromorphological thin sections. The latter greatly compliments micromorphology by providing information about char fragments without any clear morphological characteristics. This study is the first of its kind and may provide archaeologists with a robust new method to distinguish animal- from plant-derived char in thin sections.
Skill and Sensitivity to Reasons
Authors: Shepherd Joshua 
Published: January 2021

AbstractIn this paper I explore the relationship between skill and sensitivity to reasons for action. I want to know to what degree we can explain the fact that the skilled agent is very good at performing a cluster of actions within some domain in terms of the fact that the skilled agent has a refined sensitivity to the reasons for action common to the cluster. The picture is a little bit complex. While skill can be partially explained by sensitivity to reasons – a sensitivity often produced by rational practice – the skilled human agent, because imperfect, must navigate a trade-off between full sensitivity and a capacity to succeed.
Explication as a Three-Step Procedure: the case of the Church-Turing Thesis
Authors: De Benedetto Matteo 
Published: January 2021

AbstractIn recent years two different axiomatic characterizations of the intuitive concept of effective calculability have been proposed, one by Sieg and the other by Dershowitz and Gurevich. Analyzing them from the perspective of Carnapian explication, I argue that these two characterizations explicate the intuitive notion of effective calculability in two different ways. I will trace back these two ways to Turing’s and Kolmogorov’s informal analyses of the intuitive notion of calculability and to their respective outputs: the notion of computorability and the notion of algorithmability. I will then argue that, in order to adequately capture the conceptual differences between these two notions, the classical two-step picture of explication is not enough. I will present a more fine-grained three-step version of Carnapian explication, showing how with its help the difference between these two notions can be better understood and explained.
Asymptotic stability of porous-elastic system with thermoelasticity of type III
Authors: Lacheheb Ilyes , Messaoudi Salim A. , Zahri Mostafa 
Published: January 2021

AbstractIn this work, we investigate a one-dimensional porous-elastic system with thermoelasticity of type III. We establish the well-posedness and the stability of the system for the cases of equal and nonequal speeds of wave propagation. At the end, we use some numerical approximations based on finite difference techniques to validate the theoretical results.
Mazur’s rational torsion result for pointless genus one curves: examples
Authors: Dwarshuis Arjan , Roelfszema Majken , Top Jaap 
Published: January 2021

AbstractThis note reformulates Mazur’s result on the possible orders of rational torsion points on elliptic curves over$$\mathbb {Q}$$Qin a way that makes sense for arbitrary genus one curves, regardless whether or not the curve contains a rational point. The main result is that explicit examples are provided of ‘pointless’ genus one curves over$$\mathbb {Q}$$Qcorresponding to the torsion orders 7, 8, 9, 10, 12 (and hence, all possibilities) occurring in Mazur’s theorem. In fact three distinct methods are proposed for constructing such examples, each involving different in our opinion quite nice ideas from the arithmetic of elliptic curves or from algebraic geometry.
Wave Breaking in Undular Bores with Shear Flows
Authors: Bjørnestad Maria , Kalisch Henrik , Abid Malek , Kharif Christian , Brun Mats 
Published: January 2021

AbstractIt is well known that weak hydraulic jumps and bores develop a growing number of surface oscillations behind the bore front. Defining the bore strength as the ratio of the head of the undular bore to the undisturbed depth, it was found in the classic work of Favre (Ondes de Translation. Dunod, Paris, 1935) that the regime of laminar flow is demarcated from the regime of partially turbulent flows by a sharply defined value 0.281. This critical bore strength is characterized by the eventual breaking of the leading wave of the bore front. Compared to the flow depth in the wave flume, the waves developing behind the bore front are long and of small amplitude, and it can be shown that the situation can be described approximately using the well known Kortweg–de Vries equation. In the present contribution, it is shown that if a shear flow is incorporated into the KdV equation, and a kinematic breaking criterion is used to test whether the waves are spilling, then the critical bore strength can be found theoretically within an error of less than ten percent.