bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitro derivatives of quinoline and quinoline N-oxide as low-cost alternative for the treatment of SARS-CoV-2 infection
Authors: Assis Letícia Cristina , Castro Alexandre Alves de , Jesus João Paulo Almirão de , Nepovimova Eugenie , Kuca Kamil , Ramalho Teodorico de Castro , Porta Felipe de Almeida La 
Published: May 2020

Abstract
A new and more aggressive strain of coronavirus, known as SARS-CoV-2, which is highly contagious, has rapidly spread across the planet within a short period of time. Due to its high transmission rate and the significant time–space between infection and manifestation of symptoms, the WHO recently declared this a pandemic. Because of the exponentially growing number of new cases of both infections and deaths, development of new therapeutic options to help fight this pandemic is urgently needed. The target molecules of this study were the nitro derivatives of quinoline and quinoline N-oxide. Computational design at the DFT level, docking studies, and molecular dynamics methods as a well-reasoned strategy will aid in elucidating the fundamental physicochemical properties and molecular functions of a diversity of compounds, directly accelerating the process of discovering new drugs. In this study, we discovered isomers based on the nitro derivatives of quinoline and quinoline N-oxide, which are biologically active compounds and may be low-cost alternatives for the treatment of infections induced by SARS-CoV-2.
Movimentos, Tecnologia e Pessoas Negras: é possível um outro turismo?
Authors: Alves Ferreira Michel , Salete Casagrande Lindamir 
Published: May 2020

Este estudo, de natureza teórico/metodológica qualitativa e bibliográfica, objetiva tecer uma discussão crítica acerca das vivências/experiências de pessoas negras no turismo, tendo como elementos teóricos balizadores centrais os construtos de tecnologia de Andrew Feenberg e o conceito de racismo cotidiano, teorizado por Philomena Essed. Para corroborar com o objetivo central deste artigo e seus argumentos teóricos, buscou-se uma empresa brasileira online de acomodações/hospedagens compartilhadas, voltada especialmente às pessoas negras viajantes. Destarte, foram transcritos três fragmentos de relatos de pessoas negras à empresa analisada, uma vez que estas pessoas vivenciaram situações de discriminação misóginas e/ou racistas ao experienciarem o turismo, seja como visitantes ou anfitriões de hospedagens. Por fim, se buscam possibilidades democráticas e não maniqueístas para responder à pergunta título deste artigo: é possível um outro turismo?
Palavras-chave: Tecnologia. Intersubjetividade. Racismo Cotidiano. Pessoas Negras. Turismo.
Noncoding RNAs in Medicinal Plants and their Regulatory Roles in Bioactive Compound Production
Authors: Li Caili , Wang Meizhen , Qiu Xiaoxiao , Zhou Hong , Lu Shanfa 
Published: May 2020

Background:
Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), small interfering
RNAs (siRNAs) and long noncoding RNAs (lncRNAs), play significant regulatory roles in plant development
and secondary metabolism and are involved in plant response to biotic and abiotic stresses.
They have been intensively studied in model systems and crops for approximately two decades and massive
amount of information have been obtained. However, for medicinal plants, ncRNAs, particularly
their regulatory roles in bioactive compound biosynthesis, are just emerging as a hot research field.

Objective:
This review aims to summarize current knowledge on herbal ncRNAs and their regulatory
roles in bioactive compound production.

Results:
So far, scientists have identified thousands of miRNA candidates from over 50 medicinal
plant species and 11794 lncRNAs from Salvia miltiorrhiza, Panax ginseng, and Digitalis purpurea.
Among them, more than 30 miRNAs and five lncRNAs have been predicted to regulate bioactive
compound production.

Conclusion:
The regulation may achieve through various regulatory modules and pathways, such as
the miR397-LAC module, the miR12112-PPO module, the miR156-SPL module, the miR828-MYB
module, the miR858-MYB module, and other siRNA and lncRNA regulatory pathways. Further functional
analysis of herbal ncRNAs will provide useful information for quality and quantity improvement
of medicinal plants.
Role of P-gp and HDAC2 and their Reciprocal Relationship in Uncontrolled Asthma
Authors: Mishra Ravi , Chaturvedi Rachna , Hashim Zia , Nath Alok , Khan Ajmal , Gupta Mansi , Singh Harshit , Agarwal Vikas 
Published: May 2020

Introduction:
Resistance to corticosteroid is an essential mechanism in uncontrolled asthma
as the corticosteroid is the mainstay of therapy. There are recent reports that epigenetic factors play a
crucial role in the regulation of steroid action. Overexpression of P glycoprotein (P-gp) and reduced
expression of Histone Deacetylase 2 (HDAC2) have been linked to regulating the steroid action in other
diseases like Nephrotic Syndrome (NS). However, their role in uncontrolled asthma is still not clear
and warrants further investigation. We evaluated the expression and activity of P-gp and HDAC2 in
patients with Controlled Asthma (CA) and Uncontrolled Asthma (UA).

Methods:
A total of 60 CA (mean age 51.72±17.02 years, male=38), and 38 of UA (mean
age=53.55±11.90 years, male=17) were recruited. The level of control was defined according to
(Global Initiative for Asthma) GINA 2016 criteria. The mRNA expression of HDAC2 and P-gp was
studied by quantitative real-time Polymerase Chain Reaction (PCR), the functional activity of P-gp
was evaluated by a commercially available kit via flow cytometry, and HDAC2 enzymatic activity was
measured by commercially available kit by Enzyme-Linked Immunosorbent Assay (ELISA).

Results:
P-gp expression and the functionality were significantly higher in the UA group of patients as
compared to the CA group of patients (p<0.005), moreover HDAC2 expression was significantly reduced
in UA patients as compared to CA patients, (p<0.005). The enzymatic activity of HDAC2 was also significantly
reduced in UA patients as compared to CA patients (p<0.005).

Conclusion:
P-gp overexpression and HDAC2 under expression play an essential role in uncontrolled
asthma by impairing the response to corticosteroid.
In Vitro Kinetic Hydrolysis Study of Metronidazole Derivatives with Carvacrol and Eugenol Using Validated RP-HPLC Method
Authors: Alarjah Mohammed 
Published: May 2020

Background:
Prodrugs principle is widely used to improve the pharmacological and pharmacokinetic properties of
some active drugs. Much effort was made to develop metronidazole prodrugs to enhance antibacterial activity and
or to improve pharmacokinetic properties of the molecule or to lower the adverse effects of metronidazole.

Objective:
In this work, the pharmacokinetic properties of some of monoterpenes and eugenol pro metronidazole
molecules that were developed earlier were evaluated in-vitro. The kinetic hydrolysis rate constants and half-life
time estimation of the new metronidazole derivatives were calculated using the validated RP-HPLC method.

Method:
Chromatographic analysis was done using Zorbbax Eclipse eXtra Dense Bonding (XDB)-C18 column of
dimensions (250 mm, 4.6 mm, 5 μm), at ambient column temperature. The mobile phase was a mixture of sodium
dihydrogen phosphate buffer of pH 4.5 and methanol in gradient elution, at 1ml/min flow rate. The method was
fully validated according to the International Council for Harmonization (ICH) guidelines. The hydrolysis process
carried out in an acidic buffer pH 1.2 and in an alkaline buffer pH 7.4 in a thermostatic bath at 37ºC.

Results:
The results followed pseudo-first-order kinetics. All metronidazole prodrugs were stable in
the acidic pH, while they were hydrolysed in the alkaline buffer within a few hours (6-8 hr). The rate
constant and half-life values were calculated, and their values were found to be 0.082- 0.117 hr-1 and
5.9- 8.5 hr., respectively.

Conclusion:
The developed method was accurate, sensitive, and selective for the prodrugs. For most of the
prodrugs, the hydrolysis followed pseudo-first-order kinetics; the method might be utilised to conduct an in-vivo
study for the metronidazole derivatives with monoterpenes and eugenol.
Penerapan Media Bimbingan Konseling untuk Meningkatkan Keterampilan Guru BK dalam Memberikan Layanan Pendidikan Seks terhadap Peserta Didik
Authors: Yuliastini Ni Komang Sri , Dharma Tari I Dewa Ayu Eka Purba , Putra Giri Putu Agus Semara , Dartiningsih Made Wery 
Published: May 2020

Tujuan pengabdian ini adalah peningkatan keterampilan Guru Bimbingan dan Konseling dalam membuat materi dan media Bimbingan dan Konseling pada SMP Swastika Kapal, Kab. Badung. Media bimbingan dan konseling ialah segala sesuatu yang dapat digunakan untuk menyampaiakan pesan bimbingan dan konselinya yang merangsang pikiran, perasaan, perhatian, keinginan konseli untuk memahami diri dan mengambil keputusan atau masalah yang sedang dihadapi. Sasaran kegiatan pengabdian masyarakat adalah Guru Bimbingan Konseling SMP Swastika Kapal. Kegiatan diharapkan memberikan kontribusi kepada Sekolah, guru BK serta peserta didik, dimana dari pihak sekolah menambah perangkat pembelajaran berupa media BK, guru BK memiliki pengetahuan dan kreativitas untuk menuangkan materi BK salah satunya pendidikan seks dan bagi peserta didik memberikan wawasan mengenai pendidikan seks serta mencegah perilaku yang menyimpang bagi remaja. Menghasilkan produk media BK yang interaktif sesuai tema yaitu “Pendidikan Seks pada Peserta Didik” serta hasil post test peserta didik yang tinggi mengenai pemahaman paparan materi yang disampaikan oleh guru BK merupakan keberhasilan dalam pelatihan ini. Penerapan Media BK diharapkan memiliki ragam tema dan ide yang kreatif sehingga program BK di Sekolah berjalan secara efektif.
ANALISIS PERUBAHAN PENGGUNAAN LAHAN MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS (SIG) DI GAMPONG ALUE NAGA KECAMATAN SYIAH KUALA TAHUN 2004-2019
Authors: Zalmita Novia , Alvira Yuri , Furqan M. Hafizul 
Published: May 2020

Gampong Alue Naga merupakan salah satu gampong di Kecamatan Syiah Kuala Kota Banda Aceh dan berada di kawasan pesisir yang berbatasan langsung dengan Selat Malaka. Gampong Alue Naga dipisahkan oleh Sungai Lamyong yang berada ditengah gampong. Pasca tsunami penggunaan lahan di Gampong Alue Naga mengalami perubahan yang cukup besar. Penelitian ini mengangkat masalah tentang perubahan penggunaan lahan yang terjadi Gampong Alue Naga Kecamatan Syiah Kuala. Tujuan penelitian ini adalah untuk mengetahui seberapa besar perubahan penggunaan lahan yang terjadi di Gampong Alue Naga menggunakan Sistem Informasi Geografis (SIG) menggunakan aplikasi ArcGIS pada citra temporal Gampong Alue Naga. Adapun citra temporal yang digunakan yaitu citra tahun 2004, 2009, dan 2019. Untuk melihat perubahan penggunaan lahan yang ada di Gampong Alue Naga maka peta penggunaan lahan di overlay hingga mendapatkan peta yang baru yaitu peta perubahan penggunaan lahan. Hasil menunjukkan bahwa, perubahan lahan yang terjadi di Gampong Alue Naga Kecamatan Syiah Kuala cukup signifikan pada beberapa lahan seperti lahan terbangun, kebun kelapa, dan lahan tambak.
ABSTRACT
Gampong Alue Naga is one of the villages in the Syiah Kuala District of Banda Aceh City and is located in a coastal area directly adjacent to the Selat Malaka. Gampong Alue Naga is separated by the Lamyong River in the center of the village. After the tsunami the land use in Gampong Alue Naga has experienced significant changes. This study raises the problem of land use changes that occur in Gampong Alue Naga, Syiah Kuala District. The purpose of this study was to determine how much land use change occurred in the Gampong Alue Naga using a Geographic Information System (GIS) using the ArcGIS application on the temporal image of the Gampong Alue Naga. The temporal image used is the image in 2004, 2009 and 2019. To see changes in land use in the Gampong Alue Naga, the land use map is overlaid to get a new map, namely the land use change map. The results show that land changes that occurred in Gampong Alue Naga, Syiah Kuala District were quite significant in some lands such as built up land, coconut plantations, and pond areas.
Authors: Juhadi Juhadi , Rahma Risti Ainur , Santoso Apik Budi 
Published: May 2020

Abstract
The purpose of this research is (1) analyzing the Mangrove forest management system conservation based; (2) Analyzing the potential resources of mangrove forest as edu-ecotourism. Research was conducted on the coastal area of Pasarbangi Rembang, Central Java. Qualitative research approaches; Data and information are gathered through interviews, observations, FGD and Surve ad hoc. Tenik qualitative descriptive analysis. The results showed tHat growth and development of mangrove forest resources are not separated from local community participation, which is full of awareness to manage mangrove forest sustainably. The existence of mangrove forest tHat Has been well maintained by the community and supported by local government, attracting attention from various people and made as an edu-ecotourism tourist destination.
Keywords: edu-ecotourism, mangrove forest, consevation, coastal area
Dualisme Pelestarian dan Pengembangan Musik Keroncong pada Tahun 1970-an
Authors: Mulyadi Raden Muhammad , Indira Dian 
Published: May 2020

Keroncong merupakan suatu genre musik yang khas Indonesia, keberadaanya selalu dikaitkan dengan statusnya sebagai salah satu warisan seni budaya bangsa Indonesia yang perlu dilestarikan. Selain perlu dilestarikan, para penggiat keroncong dan pemerintah pun menganggap perlu mengembangkan keroncong dalam segi musik maupun perluasan peminatnya, khususnya di kalangan generasi muda. Penelitian ini memperlihatkan popularitas keroncong yang sudah menurun sejak akhir tahun 1960-an bahkan pada tahun 1970-an keroncong sudah dinyatakan harus diselamatkan atau dilestarikan. Perkembangan keroncong terhambat oleh semangat pelestarian musik tersebut. Pelestarian keroncong terhambat oleh pakem-pakem yang ditentukan oleh para tokoh senior musik tersebut. Pakem-pakem keroncong merupakan suatu bentuk hegemoni para tokoh senior keroncong untuk memberi batasan keroncong yang baik dan benar menurut versi mereka. Pada satu sisi, pakem-pakem dalam keroncong telah dapat menjaga kelestarian keroncong, sementara pada sisi lainnya tidak berhasil mengembangkan keroncong kepada peminat yang lebih luas. Keroncong is a music genre that is typical of Indonesia, its existence is always associated with its status as one of the Indonesian cultural arts heritage that needs to be preserved. Besides needing to be preserved, keroncong activists and the government also consider it necessary to develop keroncong in terms of music and the expansion of their interests, especially among the younger generation. This study examine that the popularity of keroncong which has declined since the late 1960s even in the 1970s that keroncong has been declared to be saved or preserved. Keroncong development is hampered by the spirit of preservation of the music. Keroncong conservation is hampered by the standards determined by the senior figures of the music. Pakem-pakem (standards) keroncong is a form of hegemony of senior keroncong figures to limit the keroncong to good and correct according to their version. On the one hand, the features in keroncong have been able to preserve keroncong, while on the other hand they have not succeeded in developing keroncong for wider interested ones.
KONSEPSI SENI BORIS PASTERNAK DALAM “DEFINISI PUISI”
Authors: Gumilar Tisna , Prabasmoro Tisna , Budhyono Rasus 
Published: May 2020

Tulisan ini mencoba mencari sebuah konsep estetik Boris Pasternak melalui penelusuran puisi ars poetica-nya berjudul Определение поэзии [Opredjelenje Poezzia] ‘Definisi Puisi’. “definisi puisi” diasumsikan sebagai representasi imaji personalitas pengarangnya baik melalui pernyataan langsung yang berhubungan dengan personalitas pengarang (pengetahuan atau pandangan-pandangan yang diekspresikan) juga melalui seluruh struktur karya tersebut. Untuk mencapai tujuan tersebut, dalam analisis karya digunakan pendekatan hermeneutic Ricoeur(1976) terutama mengenai teori metafora. Hermeneutika digunakan sebagai teori untuk mengungkap konsep filosofi yang terkandung dalam puisi tersebut. Definisi puisi adalah konsepsi seni Boris Pasternak yang di tuangkan dalam metafora-metafora.
Efficient Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer
Authors: Cambeiro Xacobe , Larionova Natalia A. , Miyatake Ondozabal Jun 
Published: May 2020

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled thedevelopment of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism, key to circumventthe problems associated with the low electron affinity of alkenes, is supported by experimental and computational studies. The reaction is appliedto a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawingsubstituents in the aromatic ring and with good functional group compatibility.
PARANOID SCHIZOPHRENIA AND THE PARADOXICAL PATH TO PARAPHRENIA AND AFFECTIVITY – A CASE STUDY
Authors: Voicu Tiana , Chipeșiu Ana Maria , Trifu Simona 
Published: May 2020

Motivation: Analyzing a case of paranoid schizophrenia is a challenge to understand the mechanisms underlying the mind of a schizophrenic. The study became captivating because in the patient's delusional cofabulations there were many fingerprints that the communist period of that time left on the woman's psyche, thus observing the repressions following personal failures that probably led to the current state.
Objective: Carrying out an analysis of the life history of a patient with paranoid schizophrenia who, although voluntarily presenting at the hospital, does not recognize her diagnosis and treatment. It presents symptoms that include the delusional ideas of persecution or greatness. It has two possible admissions, currently admitted to the psychiatric department in Bucharest.
Results: The patient presents disorders regarding perception, memory, affectivity, observing a disorganized discourse that includes a qualitative perceptual disorder, schizophrenia-specific hypoprosexias, disorders of the immediate mental synthesis with illusions of non-recognition, impossibility of evoking recent events, mental and ideation disorganization, the reversal of the affective, which generates conflicting emotional experiences.
Conclusion: Although the patient is under treatment, insight is still not present, so patient supervision is recommended. The paranoid nucleus has diminished, but delusional ideas still persist, and the patient became affected during hospitalization.
ASSESSMENT OF PROFITABILITY OF WATER MELON (CITRILLUS LANATUS) IN SELECTED MARKETS IN PARTS OF KADUNA NORTHERN GUINEA SAVANNAH OF NIGERIA
Authors: Sodimu A.I , Usman M.B , Oladele N.O , Lapkat L.G. , Awobona T.A , Suleiman R 
Published: May 2020

The study examines the assessment of profitability of watermelon (Citrillus lanatus) in selected markets in parts of Kaduna Northern Guinea Savanna of Nigeria. One hundred questionnaires were randomly administered (100) and 51 were recovered from the respondents. Descriptive statistics gross margin analysis and Z- test were used to analyze the data collected. The results revealed that 74.51% of the respondents are male and 25.29% are female. Majority of the respondents are aged between 35 – 45 years (43.14%) and 12.55% are married. 35.29% of the respondent had secondary education and 39.21% had primary education. The gross margin analysis shows a significant level of profitability at (P>0.05) with estimated net income of #10,851.20 per annum. The Z- test further shows that the calculated value was statistically significant at (P>0.05) probability level. However, recommendation for improvement and marketing of the species were highlighted.
Pembuatan Pakan Pellet Moist Berbahan Baku Lokal Untuk Budidaya Lobster di Karamba Jaring Apung
Authors: Cokrowati Nunik , Setyowati Dewi Nu'Aeni , Diniarti Nanda , Mukhlis Alis , Perwitasari Woro Kusumaningtyas , Amiri Mochammad 
Published: May 2020

Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan keterampilan pembuatan pakan pellet moist pada pembudidaya lobster yang ada di desa Batunampar Selatan. Kegiatan ini dilaksanakan pada tanggal 29 Juli 2016. Metode yang digunakan pada kegiatan ini adalah tutorial dan praktek langsung. Tutorial dilakukan dengan cara memberi penjelasan pentingnya pengetahuan dan keterampilan membuat pakan buatan, formulasi pellet moist dan keterkaitannya dengan biaya produksi budidaya. Kegiatan ini dilakukan di Desa Batunampar Selatan Kecamatan Jerowaru Kabupaten Lombok Timur. Kegiatan dilakukan di kantor desa dan karamba jaring apung lobster. Peserta kegiatan ini terdiri dari 10 orang pembudidaya lobster dan kerapu, 5 orang aparat desa dan 2 orang perwakilan Dinas Kelautan dan Perikanan Kabupaten Lombok Timur. Tim kegiatan ini adalah 5 orang dosen Program Studi Budidaya Perairan dan 2 orang peneliti dari BPBLL Sekotong. Pakan yang dibuat adalah pellet moist untuk lobster. Formulasi pakan moist lobster yang dilakukan di kegiatan ini adalah 500 gram ikan rucah, 2 kg tepung pakan udang, 400 gram Vitamin ikan, 400 gram binder pakan dan 250 ml Air. Alat yang digunakan adalah blender, panci kukusan, kompor gas, cetakan pakan, ember, baskom, pisau, gunting, sendok, dan nampan. Cara pembuatan pellet moist adalah dengan tahapan 1) Ikan rucah dihaluskan; 2) Tepung pakan udang, ikan rucah; 3) vitamin, air dan binder di blender hingga tercampur rata; 4) Adonan dicetak menggunakan cetakan pakan; 5) Pakan dikukus selama 10 menit kemudian dijemur hingga kering. Pellet moist diberikan ke lobster yang dibudidayakan di karamba jaring apung. Keywords: Teknologi; pakan buatan; nutrisi; ikan rucah, pertumbuhan; biaya; produksi.
PENCEGAHAN TERHADAP PELANGGARAN HAK PEREMPUAN SEBAGAI PEKERJA BERDASARKAN UNDANG-UNDANG NOMOR 13 TAHUN 2003
Authors: Widyaningrum Hesti 
Published: May 2020

Peningkatan daya produksi oleh perusahaan sangat dibutuhkan dalam memenuhi kebutuhan pasar baik dalam skala nasional, maupun global. Tenaga kerja sangat dibutuhkan dalam sistem produksi suatu perusahaan. Kebutuhan terhadap jumlah tenaga kerja tidak hanya pada pekerja laki-laki akan tetapi juga pada perempuan. Kondisi hari ini, beberapa perusahaan di Indonesia membutuhkan pekerja perempuan dalam mendukung produksinya. Peningkatan tersebut, mestinya seiring meningkatnya proteksi hak pekerja perempuan dalam Hubungan Industrial, Sayangnya, banyak kasus terhadap pelanggaran di berbagai daerah masih saja terjadi. Berdasarkan latar belakang ini, Penulis mengadakan Pengabdian Kepada Masyarakat dalam bentuk penyuluhan mengenai “Pencegahan terhadap Pelanggaran Hak Perempuan sebagai Pekerja Berdasarkan Undang-Undang Ketenagakerjaan.”Pelaksanaan kegiatan ini di PT. PAS (Prakarsa Alam Segar), Bekasi. Perusahaan ini memiliki 80% pekerja perempuan dari seluruh pekerja sebanyak 5.925 pekerja. Peserta kegiatan ini sebanyak 71 peserta dan 40% dari peserta adalah perempuan. Walaupun begitu, Informasi yang disampaikan oleh Penulis tetap tersampaikan terhadap peserta sesuai dengan tujuan semula. Ini dilihat dari hasil Pra dan Pasca tes yang diberikan kepada peserta. Berdasarkan hasil pelaksanaan kegiatan, Secara normatif hak pekerja perempuan telah dipenuhi oleh pihak Perusahaan sebagaimana diatur dalam perjanjian kerja bersama mereka. Sayangnya, ada beberapa klausul dalam perjanjian tersebut, yang membuat hak mereka sulit untuk dipenuhi oleh Perusahaan. Seperti salah satu contohnya, adanya kewajiban menyerahkan surat keterangan dokter ketika mengajukan cuti haid. Adanya perjanjian tersebut membuat, perlindungan hak perempuan sebagai pekerja menjadi terabaikan. Akibatnya, Fungsi reproduksi pekerja dapat terganggu, maka hasil produktivitasnya juga ikut terganggu. Selain itu juga Pengabaian pemenuhan hak mereka dapat memicu timbulnya sengketa antara pekerja dan perusahaan.