bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study
Authors: Xie Jinzhao , Wang Zixin , Li Quanmin , He Qiangsheng , Xu Guohong , Li Yonghong , Zhou Kai , Li Linghua , Gu Jing 
Published: September 2020

Abstract
Background: Antiretroviral therapy (ART) coverage has increased sharply. This prospective observational cohort study investigated the association between experiences related to ART and mental health problems among a sample of people living with HIV in China.Methods: The participants were 400 people living with HIV who had started ART for the first time in Guangzhou city. They were followed-up one-year after ART initiation. Probable depression and moderate/severe anxiety were measured at baseline and Month 12, while experiences related to ART were measured at Month 6. Univariate and multivariate logistic regressions were used to explore the predictors of mental health status.Results: Among the 300 participants (75.0%) who completed all three surveys, a significant decline in prevalence of probable depression (23.0% at baseline vs. 14.0% at Month 12, P = 0.002) and moderate/severe anxiety (14.7% at baseline vs. 8.7% at Month 12, P = 0.023) was observed during the follow-up period. After adjustment for mental health status and potential confounders at baseline, a number of ART-related experiences at Month 6 were associated with probable depression and/or moderate/severe anxiety measured at Month 12. Improved physical health, relationships with sexual partners, and self-confidence were associated with decreased mental health issues, while the side effects of ART, AIDS-related symptoms, and inconvenience in daily life due to ART use were associated with increased mental health issues.Conclusions: ART-related experiences were predictors of mental health problems, tailored mental health promotion interventions targeting these experiences are needed.
Association Between Triglyceride Glucose Index and Risk of New-onset Diabetes Among Chinese Adults: Findings From the China Health and Retirement Longitudinal Study
Authors: Chen Chaolei , Liu Lin , LO Kenneth , HUANG Jiayi , Yu yuling , HUANG yuqing , Yingqing Feng 
Published: September 2020

Abstract
BackgroundThe triglyceride glucose (TyG) index has been proposed to be a simple surrogate of insulin resistance. We aimed to examine the relationship between TyG index and risk of incident diabetes in middle-age and elderly adults in China.MethodsNationally representative data from the China Health and Retirement Longitudinal Study 2011-2015 were used. Sociodemographic, medical, anthropometric, and laboratory information were collected following a standard protocol. Cox proportional hazards models and restricted cubic spline regression were performed to estimate hazard ratio (HR) with 95% confidence interval (CI) of diabetes for TyG index. Subgroup analyses were also conducted to examine potential interactions. ResultsOf 7428 participants without at baseline diabetes, 791 (10.6%) participants developed diabetes over 3.4 years of follow-up. The multivariate HR for every SD increase in TyG index was 1.22 (95% CI, 1.14-1.31). When dividing TyG index into quartiles, the multivariate HRs for new-onset diabetes were 1.22 (0.96-1.54) for Q2, 1.61 (1.28-2.01) for Q3, and 1.73 (1.38-2.16) for Q4 (P for trend < 0.001) compared with Q1. The restricted cubic spline regression confirmed a linear association. No interaction was found between subgroup variables and association of TyG index with risk of diabetes.ConclusionTyG index was significantly and positively associated with risk of new-onset diabetes in middle-aged and elderly adults. TyG index may be a useful predictive marker for predicting new-onset diabetes.
Validation of the Functions and Prognostic Values of Synapse Associated Proteins in Lower-Grade Glioma
Authors: Lin Han , Yang Yong , Hou Chongxian , Zheng Jiantao , Lv Guangzhao , Mao Rui , Xu Peihong , Chen Shanwei , Zhou Yujun , Wang Peng , Zhou Dong 
Published: September 2020

Abstract
BackgroundSynapse and synapse associated proteins (SAPs) play critical roles in various neurodegeneration diseases and brain tumors. However, in lower-grade gliomas (LGG), SAPs have not been explored systematically. Herein, we are going to explore SAPs expression profile and its clinicopathological significance in LGG which can offer new insights to glioma therapy. MethodIn this study, we used five sources including, Venkatesh, Shen, Colón, Jüttner R, Gene Ontology (GO) project to integrate a list of SAPs that covered 231 proteins with synaptogenesis activity and post synapse formation. The LGG RNA-seq data were downloaded from gene expression omnibus (GEO) database, The Cancer Genome Atlas (TCGA), and Chinese Glioma Genome Atlas (CGGA). The differentially expressed SAPs were filtered out and constructed PPI to search for key modules and SAPs. Then, using Kaplan–Meier survival analysis, least absolute shrinkage and selection operator (LASSO), and multicox regression analysis, the prognostic significance of these key SAPs was evaluated. CGGA database, Human Protein Altas (HPA) and quantitative real-time PCR were used to verify our findings. ResultData from function enrichment analysis revealed functions of differentially expressed SAPs in synapse organization and glutamatergic receptor pathway in LGGs. Survival analysis revealed four SAPs, GRIK2, GABRD, GRID2, ARC that were correlate with the prognosis of LGG patients and used to construct the prognostic models. Among them, the expression of GABRD was lower in glioma tissue than normal brain tissue, but higher in seizure LGG patients than non-seizure patients. The four-SAPs signature was revealed as an independent prognostic factor in gliomas. ConclusionOur study presented a novel strategy to assess the prognostic risks of LGGs, based on the expression of SAPs. Also, we revealed that several SAPs upregulated in patients with seizures, indicating that they are linked to the pathogenesis of seizures in glioma patients.
Evaluation of Intracranial Pressure by Ultrasound of the Optic Nerve Sheath in an Animal Model of Intracranial Hypertension
Authors: Jeng Brasil P , Andrade Almir F , Bor-Seng-Shu Edson , Belon Alessandro R , Robertis Maira , Oliveira Marcelo L , Rubiano Andres M , Godoy Daniel A , Teixeira Manoel J , Paiva Wellingson Silva 
Published: September 2020

Abstract
Background: Invasive monitoring of intracranial pressure is currently the only accepted method for the safe diagnosis and treatment of intracranial hypertension, but it is subject to hemorrhage, infection and malfunction. Ultrasound of the optic nerve sheath diameter is a non-invasive alternative that is cost effective and available at the bedside. The objective of this study was to correlate intracranial pressure and ultrasonography of the optic nerve sheath in an experimental animal model of cerebral hematoma. Materials and Methods: An experimental study was conducted on 30 male and female pigs wighing about 20 kg. The diameter of the optic nerve sheath was measured by ultrasound at different points of intracranial pressure. Intracranial pressure was simultaneously measured with an intraparenchymal catheter, and laboratory and hemodynamic data was collected from the animals. The values were correlated with each other to explore the application of this procedure in different clinical situations involving intracranial hypertension. Results: All the variables obtained by ONSD ultrasonography (Left Optic nerve LON, Rigth optic nerve RON and Avarage of Optic Nerve sheath AON) were statistically significant to predict the ICP value. AON presentation changes in relation to baseline from the moment of balloon inflation. AON proved to be the best parameter for predicting ICP and presented the best correlation. AON showed a delay of 30 minutes compared to ICP decrease, as it maintained values higher than baseline values at the ballon deflation moment (p = 0.016). Thus, intracranial pressure can be predicted using the linear function: -80.5 + 238.2 × the optic nerve sheath diameter. Conclusion: Optic nerve sheath diameter ultrasound is a reliable method for predicting intracranial pressure.
Increased Bone Formation and Bone Resorption in Patients with Hemophilic Arthropathy: A Cross-Sectional Study
Authors: Zhang Shengyang , He Bangjian , Xu Huihui , Shi Zhenyu , Tong Peijian , Mao Qiang 
Published: September 2020

Abstract
Background: Previous studies have revealed that hemophilia patients with severe osteoporosis have more arthropathy symptoms and that their bone metabolism is frequently abnormal. However, it is unclear how to achieve an early diagnosis of hemophilic arthropathy (HA) through abnormalities in bone metabolism.Methods: This study includes 46 patients with HA, 48 healthy controls (HC) and 43 hemophilia without arthropathy (HWA) patients (5 patients were excluded). We measured and compared bone turnover markers (BTMs) including osteocalcin (OC), n-terminal procollagen 1 elongating pro-peptide (t-P1NP) and β-isomerized collagen I-c-terminal peptide breakdown product (β-CTx) of three groups. Receiver operating characteristic (ROC) curve was drawn to obtain the critical value of BTMs for the diagnosis of HA. One-way ANOVA was used to compare the BTMs levels in different degrees of hemophilia. Multivariate linear regression was performed to analyze the correlation between BTMs and clinical severity of HA. Results: The t-P1NP, β-CTx and OC levels of HA and HWA patients were higher than HC, and HA patients had higher t-P1NP and β-CTx levels than HWA patients (p<0.001). But there was no significant difference in OC levels between HA and HWA groups. Logistic regression analysis revealed that high β-CTx and high t-P1NP were significantly associated with HA. ROC curve showed the highest area under the curve was the t-P1NP+β-CTx model (area under the curve was 0.686, the sensitivity was 54.5% and the specificity was 82.5%, the cut-off value was 0.578). Multivariate linear regression analysis indicated that β-CTx was positively correlated with the clinical severity of HA, and t-P1NP levels was negatively correlated with the clinical severity of HA. β-CTx levels decreased with the degree of hemophilia. Conclusions: Increased bone resorption and bone formation were associated with the onset of HA, and the t-P1NP+β-CTx model (β-CTx >775.200 ng/mL and t-P1NP>55.100 ng/mL) contributed to the diagnosis of HA.
Perfusion Technique in Total Arch Replacement to Prevent Cerebral Stroke in Patients Over 75 Years Old a Single Center Retrospective Cohort Study
Authors: kasama keiichiro , Uchida Keiji , Goda Motohiko , Suzuki Shinishi , Imoto Kiyotaka , Takebayashi Shigeo , Misumi Toshihiro , Masuda Munetaka 
Published: September 2020

Abstract
BackgroundTo evaluate the efficacy of isolated cerebral perfusion (ICP) for the prevention of cerebral infarction and the occurrence of early mortality, we retrospectively compared the outcomes between old patients with or without ICP in total arch replacement (TAR)MethodsBetween January 2003 and March 2019, 74 patients aged older than 75 years underwent elective TAR for arch aneurysm. The participants were divided into two groups according to the brain protection method used: the ICP method (ICP group, n = 46) and the selective antegrade cerebral perfusion method (non-ICP group, n = 28). ResultsThe 30-day mortality rates of both groups were zero. The in-hospital mortality rates of the ICP and non-ICP groups were 4.3% and 3.5%, respectively. The median follow-up duration was 34 months, and the 1-year survival rates were 90.1% in the ICP group and 90.7% in the non-ICP group. The incidence of postoperative cerebral infarction was significantly lower in the ICP group (n = 1, 2.1%) than in the non-ICP group (n = 5, 17.8%).ConclusionsICP could result in a lower incidence of postoperative cerebral infarction in old patients who undergo TAR.
The Effects of Chronic Branched-Chain Amino Acid Supplementation on Running Kinematics: Single Case Research
Authors: Whiton Tara K. , Sato Kimitake , Bazyler Caleb , DeWeese Brad , Stone Michael H 
Published: September 2020

Abstract
Purpose: To monitor the effects of chronic branched-chain amino acid (BCAA) supplementation on running kinematics in a trained ultra-endurance runner. Methods: One well-trained ultra-endurance runner followed three 10-day cycles of an AB design consuming a BCAA drink (SUP) or placebo (PLA) surrounding daily key workouts leading up to a 50-mile race (dosage = 0.08g/kg/day = 3.52g BCAA/day and 10.32g AA/day). During each 10-day cycle, the athlete completed a 5km run on an outdoor track at 6:30min/mile pace. A 10-meter capture zone was measured and marked with two orange cones for video recording and analysis. Kinovea open-source software (Version 0.8.15) was used to measure running kinematic variables: ground contact time (GCT), flight time (FT), and vertical oscillation (VO). Results: Vertical oscillation (VO) during a constant-pace run was significantly reduced from 88mm to 76mm when athlete was on SUP vs PLA condition (p = 0.00, Tau-U = 0.40). Statistical significance was not achieved for differences in GCT and FT between SUP and PLA (p = 0.06, Tau-U = 0.-17 and p = 0.28, Tau-U = 0.10 for GCT and FT, respectively). Weighted Tau-U results suggest that the BCAA supplement was overall 11% effective in improving combined measures of running kinematics (p = 0.04, Tau-U = 0.11). Discussion: A decrease in VO can indicate less overall muscle support requirements during stance phase and a reduced aerobic demand for a given task. We observed decreased VO during the 5km running tests on SUP indicating a reduction in wasteful vertical motion. Possible explanations for this could relate to improvement in muscle recovery characteristics from increased availability of BCAAs resulting in less chronic fatigue. Less fatigue can allow greater coactivation between two-joint muscles of the leg during stance resulting in more efficient joint rotations that are transferred into desired external forces, promoting more efficient movement and a more economical runner.
Comparison of the efficiency, safety and survival outcomes in two stem cells mobilization regimens with cyclophosphamide plus G-CSF or G-CSF alone in multiple myeloma: a meta-analysis
Authors: Wang Liwen , Xiang Hongxian , Yan Yuhan , Deng Zuqun , Li Hui , Li Xin , Liu Jing 
Published: September 2020

Abstract
Background Autologous stem cell transplantation as a frontline treatment for patients with multiple myeloma (MM), it requires an adequate peripheral blood stem cells (PBSC) collection before processing. Granulocyte-colony stimulating factor (G-CSF) with or without cyclophosphamide (CTX) are common regimens for PBSC mobilization, their benefits and risks are controversial. Methods To compare the efficiency, safety, and survival outcomes between the two regimens, we conducted a meta-analysis including 18 studies with 4 prospective and 14 retrospective studies, a total of 2770 patients with MM analyzed. Results The CTX plus G-CSF regimen had higher yields of total CD34+ cells (SMD = 0.39, 95% CI (0.30, 0.49)), and higher mobilization rates of the target ⩾ 2x106/kg (OR = 3.34, 95% CI (1.82, 6.11)) and 4x106/kg (OR = 2.16, 95% CI (1.69, 2.76)) cells. A favorable EFS (HR = 0.73, 95% CI (0.58, 0.93), p = 0.01) and better 3-year EFS rate (OR = 1.65, 95% CI (1.1, 2.47), p = 0.02) were also reached in the patients with CTX plus G-CSF mobilization, although the risks of admission (OR = 26.49, 95% CI (7.31, 95.97)) and fever (OR = 13.66, 95% CI (6.21, 30.03)) during mobilization were increased, the treatment-related mortality were consistent (p = 0.26). Conclusions The CTX plus G-CSF regimen was superior to the G-CSF-alone regimen for PBSC mobilization in patients with MM.
Ultra-early indicators of acute hypertriglyceridemic pancreatitis may affect treatment decision-making
Authors: Wu Jing , Tang Xiaoting , Li Chaowei , Rao Zilan , Liang Yizhi , Pan Xiaoping , Fang Taiyong 
Published: September 2020

Abstract
Background: The present study aimed to investigate whether the ultra-early indicators can predict severity of acute hypertriglyceridemic pancreatitis (HTGP) and affect clinical decisions. Methods: We performed an observational retrospective study with data from 110 enrolled patients with HTGP from January 2017 to February 2020. According to the final clinical outcome, HTGP patients were divided into MAP group and MSAP-SAP group. Demographic and clinical data were collected, and ultra-early indicators (serum calcium, TG, IL-6, D-dimer, HbAc1, arterial lactate) levels were measured within 6 h of admission. A multivariate logistic regression analysis model and receiver operating characteristic curve were adopted to evaluate the value of ultra-early indicators for identifying high-risk patients. The chi-square test method was used to estimate the time of hospitalization and complications in MSAP-SAP group after plasma exchange within or more than 24 hours. Results: Of the 110 HTGP patients, a total of 56 patients with mild AP and 54 MSAP-SAP HTGP patients included. TG, IL-6, D-dimer, HbAc1, and arterial lactate levels which measured within 6 h after admission were significantly higher in the MSAP-SAP group, but serum calcium was significantly lower, versus the mild AP group. IL-6, D-dimer, and serum calcium were found to be risk factors for MSAP-SAP and could ultra-early predict HTGP severity, particularly within 6 hours of admission. We found that patients of MSAP-SAP treated with Blood purification within 24 hours of admission have shorter hospital stay time than over 24 hours of admission. Conclusion: Ultra-early indicators of IL-6, D-dimer, and serum calcium may be useful biomarkers for assessing AP severity in HTGP patients within 6 hours. Early blood purification therapy should be taken for MSAP-SAP patients within 24 hours, because fewer patients could suffer from complications and more patients had shorter hospital stay time. While traditional treatment could be implemented for MAP patients to reduce medical expenses and still obtain good therapeutic effect. Keywords: Hypertriglyceridemic pancreatitis, Ultra-early indicators, Clinical decisions, Therapeutic effect
Circulating long non-coding RNAs as potential biomarkers for stomach cancer: A systematic review and meta-analysis
Authors: Cao Fang , Hu Yongwei , Chen Zaichang , Han Wei , Lu Weijie , Xu Jianhao , Ding Houzhong , Shen Xiaojun 
Published: September 2020

Abstract
Background: Recent researches have suggested that long non-coding RNA (lncRNA) is involved in the tumorigenesis and development of stomach cancer (SC). This meta-analysis aimed to identify the diagnostic performance of circulating lncRNAs in SC.Methods: All relevant studies were systematically searched through PubMed, Web of Science, Cochrane Library and EMBASE databases. The diagnostic values of lncRNAs were mainly assessed by pooled sensitivity (SEN), specificity (SPE), and summary receiver operating characteristic area under the curve (SROC AUC). Meta-DiSc 1.4, Review Manager 5.3 and STATA 12.0 were used for statistical analysis. Results: A total of 42 eligible studies were included in this meta-analysis. The pooled SEN, SPE, and AUC were 0.78 (95%CI: 0.75-0.81), 0.75 (95%CI: 0.71-0.78), and 0.83 (95%CI: 0.80-0.86) respectively, suggesting that the lncRNAs test had a high accuracy for the diagnosis of SC. Obvious heterogeneity might come from the type of lncRNA through subgroup and meta-regression analysis. Fagan diagram showed the clinical value of lncRNAs test in SC. Conclusions: Abnormal expression of circulating lncRNAs exhibits a high efficacy for diagnosing SC, which is promising in clinical application.
The Effectiveness Of Application Of The Leadership Style And Entrepreneurial Orientation To Improve Business Performance
Authors: Siregar Budi Alamsyah 
Published: September 2020

Abstract
An owner's leadership style determines how the company carries out the activities in achieving its performance. The entrepreneurial orientation behavior present in an owner also determines how higher business performance can improve success. This study aims to understand how the role of a manager's leadership style and entrepreneurial orientation in improving his business performance. This research used a qualitative Delphi method by collecting in-depth data from 20 company owner. The results indicate the owner's transformational leadership style, a group of medium-sized enterprises that have developed and are beginning to be established, directly determines the applied entrepreneurial orientation. Finally, the application can affect the performance of the business. Behavior entrepreneurial orientation; not only promotes business growth medium, but it can also affect large enterprises' profitability due to the indirect impact achieved by large companies through cooperation in the supply of raw materials for products. The impact of increasing innovation power, proactive power, and risk-taking power on business performance arise from the support of a transformational leadership style. When transformational leadership styles and entrepreneurial orientations combine, medium-sized enterprises will achieve higher performance.
Stereospecific Synthesis of (4E,10Z)- 4,10-Tetradecadienyl Acetate, the Major Sex Pheromone of Apple Leaf Miner Moth, Phyllonorycter ringoniella
Authors: Awalekar Ramchandra , Jagadhane Kishor , Usmani Shams , Salunkhe Shilpa , Jamale Dattatray , Hangirgekar Shankar , Kolekar Govind , Anbhule Prashant 
Published: September 2020

:
The main component of the sex pheromone of many lepidopteran pests, (4E,10Z)-4,10-tetradecadienyl acetate
(1) has been synthesized stereoselectively by using a simple route with 4-pentynol as a starting material. The stereoselective
formation of the 4E double bond is based on the stereospecific reduction of internal alkyne with lithium aluminium hydride
(LAH) while Wittig reaction was used to achieve 10Z double bond in the target pheromone component. The GC purity of
the final acetate was achieved 97.87% while isomeric purities are more than 99%. The green chemistry principle shows a
new concept towards for the multistep pheromone synthesis via green metrics calculations.
An Efficient Rapid Synthesis of Benzoxazoles and Benzothiazoles Using PMA.SiO2 at Room Temperature under Heterogeneous Conditions
Authors: Sudhakar Chithaluri , Shekar Vanam , Shyamsunder Manchi , Suryakumari Adurthi , Manojkumar Vala 
Published: September 2020

:
Treatment of 2-aminophenol (or 2-aminothiophenol) with aromatic aldehydes in the presence of phosphomolybdic acid on silica at room temperature affords the corresponding benzoxazoles (or benzothiazoles) in excellent yields (88-
96%) under heterogeneous conditions. Benzoxazoles and benzothiazoles are formed less than 10 min.
Investigation and Analytical Applications of the Reaction of N1-methylnicotinamide and Active Methylene Containing Drugs
Authors: Elsebaie Heba A. , Elhamamsy Mervat H. , Elokely Khaled M. , Eldawy Mohammed A. 
Published: September 2020

Background:
The reaction between N1-methylnicotinamide iodide (NMNI) and the active
methylene group-containing compounds yields a fluorescent product, which can be used in the
quantitative determination of certain drugs.

Objective:
The objective is to develop, adapt, and validate a simple spectrofluorometric method for
the quantitative analysis of modafinil 1, budesonide 2, allicin 3, and florfenicol 4.

Methods:
Spectral analysis (elemental analysis, 1H, 13C NMR, MS), computational methods (geometry
optimization, Gibbs free energy and pKa calculations) and spectrofluorometric approaches
were conducted.

Results:
A C4 cyclization pathway was confirmed for the formation of the fluorophore. The spectrofluorometric method showed good linearity (R2= 0.996-0.999) over concentrations of 1-50 ng/mL, 0.5-5 ng/mL, 60-150 pg/mL, and 1-15 ng/mL of the standard solutions of 1, 2, 3, and 4, respectively.

Conclusion:
The proposed method is simple and suitable for quality control and assurance studies