bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of clinohumite ± spinel in dolomitic marbles from the Makrohar Granulite Belt, Central India: Evidence for Ti mobility during regional metamorphism
Authors: Karmakar Shreya 
Published: December 2020

Abstract
The mobility of Ti, a member of high field strength elements, in metamorphic fluids is crucial to understand the recycling of commonly perceived nominally soluble elements and for mass-flux calculations during crustal processes. In this study, we present evidence for large-scale Ti mobility from a suite of clinohumite±spinel-bearing dolomitic marbles from the Makrohar area in central India. The studied rocks mostly contain dolomite and calcite (in subequal proportions) and a subordinate amount of forsterite. It commonly develops 1–5 cm thick, laterally continuous, mostly parallel, sometimes anastomosing, brown-colored clinohumite rich bands with variable spinel. Clinohumite has moderate Ti and F (TiO2 = 0.55–2.88 wt%; F = 0.94–1.88 wt%; n = 32). Textural and phase equilibria modeling indicate that clinohumite grew at the expense of forsterite + dolomite under static conditions due to infiltration of F- and Ti-bearing extremely H2O-rich fluids (XCO2 &lt; 0.03), at ~5–6 kbar pressure and ~650–700 °C temperature. The Ti and F were most likely supplied by highly channelized aqueous fluids restricted within the centimeter-thick bands. The negative volume change of the reactions further facilitated fluid ingress. The lateral continuity of the bands over several meters across multiple out-crops indicates that Ti was mobile at the meter to kilometer scale. The results are in accordance with experimental studies that solubility of Ti increases in the presence of halides and imply that Ti may be much more mobile in metamorphic fluids during regional metamorphism than previously anticipated.
Vibration research of heavy trucks. Part 2: Optimization of vehicle dynamic parameters
Authors: Ye Yong , Nguyen Vanliem , Hu Yongzhu 
Published: December 2020

In order to enhance the ride comfort, stability, and safety of heavy trucks. Based on the dynamic characteristics of the parameters of heavy trucks and its dynamic model, a multi-objective genetic algorithm are developed in the MATLAB environment and applied to optimize the dynamic parameters of vehicles. The weighted root-mean-square (RMS) accelerations of the cab and driver seat vibrations are chosen as the study goals to evaluate the results under different vehicle conditions. The obtained results show that the optimal parameters of vehicles are significantly enhanced the vehicle ride comfort under different operation conditions. Particularly, the weighted RMS accelerations of the awz and awφc are significantly reduced by 26.3 % and 35.3 % under the ISO level B of the road surface, and a vehicle speed region from 17.5 m/s to 20 m/s (63 km/h to 72 km/h).
Comparative Analysis of Risk Stratification Scores in Atrial Fibrillation
Authors: Samaras Athanasios , Doundoulakis Ioannis , Antza Christina , Zafeiropoulos Stefanos , Farmakis Ioannis , Tzikas Apostolos 
Published: December 2020

Background:
Atrial Fibrillation (AF) has become a major global health concern and is associated
with an increased risk of poor outcomes. Identifying risk factors in patients with AF can be challenging, given
the high burden of comorbidities in these patients. Risk stratification schemes appear to facilitate accurate prediction
of outcomes and assist therapeutic management decisions.

Objective:
To summarize current evidence on risk stratification scores for patients with AF.

Results:
Traditional risk models rely heavily on demographics and comorbidities, while newer tools have been
gradually focusing on novel biomarkers and diagnostic imaging to facilitate more personalized risk assessment.
Several studies have been conducted to compare existing risk schemes and identify specific patient populations
in which the prognostic ability of each scheme excels. However, current guidelines do not appear to encourage
the implementation of risk models in clinical practice, as they have not incorporated new ones in their recommendations
for the management of patients with AF for almost a decade.

Conclusion:
Further work is warranted to analyze new reliable risk stratification schemes and optimally implement
them into routine clinical life.
A Combined Method of Protein Extraction from Unorthodox Plant Samples for Proteomics
Authors: Yilmaz Can , Iscan Mesude 
Published: December 2020

Aim:
This study aimed to generate an improved method of protein extraction and purification
from plant tissues containing very high amounts of phenolic compounds and other interfering
biomolecules.

Background:
Protein extraction at proteomic studies on some plant species, including conifers, is
challenging, and the yield and quality are unpredictable.

Objective:
Two popular protocols were combined with each other to construct a novel one with enhanced
abilities to produce higher purity of samples compatible for high precision molecular systems
and analysis.

Method:
The new method was compared with the other two for their efficiencies in classical SDS-
PAGE, 2-DE and capillary chromatography applications.

Results:
All three methods were comparable in SDS-PAGE procedure; however, only the new
method created acceptable gel images in 2-DE. Bioanalyzer results, also, demonstrated that the
new method provided protein samples pure enough to be used in capillary chromatography with 2
times more peaks in electropherograms with lower noise and higher total relative protein concentrations
closest to the applied amount.

Conclusion:
The new combined method is a successful alternative for plant proteomicists with
higher yield and quality of proteins from recalcitrant tissues.

Other:
The new method could be preferred, especially, for high-tech, sensitive proteomic analysis.
Anti-Hypertensive Potential and Epigenetics of Angiotensin II type 2 Receptor (AT2R)
Authors: Chaudhary Mayank 
Published: December 2020

Background::Renin angiotensin system (RAS) is a critical pathway involved in blood pressure regulation. Octapeptide, angiotensin II (Ang II), is a biologically active compound of RAS pathway which mediates its action by binding to either angiotensin II type 1 receptor (AT1R) or angiotensin II type 2 receptor (AT2R). Binding of Ang II to AT1R facilitates blood pressure regulation, whereas AT2R is primarily involved in wound healing and tissue remodeling.Objective::Recent studies have highlighted additional role of AT2R to counter balance detrimental effects of AT1R. Activation of angiotensin II type 2 receptor using AT2R agonist has shown effect on natriuresis and release of nitric oxide. Additionally, AT2R activation has been found to inhibit angiotensin converting enzyme (ACE) and enhance angiotensin receptor blocker (ARB) activity. These findings highlight the potential of AT2R as novel therapeutic target against hypertension.Conclusion::The potential role of AT2R highlights the importance of exploring additional mechanisms that might be crucial for AT2R expression. Epigenetic mechanisms, including DNA methylation and histone modification, have been explored vastly with relation to cancer, but the role of such mechanisms in the expression of AT2R has recently gained interest.
Development and Innovation on Dental Products in Argentina: A Technological Prospecting Based on Patents
Authors: Valadas Lidia Audrey Rocha , de Oliveira Filho Rosueti Diogenes , Lotif Mara Assef Leitão , Josimar Girão Francisco , de-Alencar Emmanuel Arraes , Bandeira Mary Anne Medeiros , Squassi Aldo 
Published: December 2020

Background::
Argentina has progressed with industrialization in comparison
to other Latin American countries and this process had a direct impact on the innovative
capacity of the national economy. A constant search for market leadership, including the
dentistry field and dental materials, stimulates the industries to launch new products daily.
Inventions related to health researches are mostly protected by patents as intellectual
property. A patent landscape analysis through searches in patent banks is a tool used to
identify trends in different areas of innovations.

Objective::
This study aims to identify and evaluate the scenario of research, development
and innovation of dental products in Argentina by a technological prospecting based on
patents.

Methods::
A survey of patent documents was conducted by searching for deposited and
granted patents of dental products. The search was carried out during January 2020 in the
patent database of the National Institute of Industrial Property of Argentina (INPI-AR).
The terms “dentistry”, “buccal”, “dental” and “oral” were used to select the titles and abstracts
of patent application reports. The information extracted from patent reports was organized
in tables and Figs using Fig.Pad Prism 6 software to evaluate the applications.

Results::
A total of 363 patents were published from 1989 to 2016, mainly by international
industries, 93.3% as patent invention and 3.0% as utility model applications on dentistry.
Only two patents (0.5%) were deposited by universities, as the University of Melbourne
(Patent number 20060102378) and Universidad Nacional del Nordeste (Patent
number 20140104149), among which only the last one is national. Among the deposits,
only 6.6% were granted; mostly were in force, denied or lost. According to the specialties,
most patents were related to compositions (64.7%) and personal products (21.7%),
also on dentistry/cariology (6.33%) and prostheses/implants (4.68%).

Conclusion::
In general, we find that most patent applications are related to the preventive
area, personal products and compositions for formulations. Few dental patents deposits
are currently available in Argentina, suggesting that the importation of products into
the area remains large, which can make dental products more expensive. It is important
to invest in technology-based companies to promote increased economic activity, being
a consequence of an investment in knowledge creation and intellectual property to
the Dentistry area.
Melittin: A Natural Peptide with Expanded Therapeutic Applications
Authors: Tiwari Ruchi , Tiwari Gaurav , Lahiri Akanksha , Ramachandran Vadivelan , Rai Awani 
Published: December 2020

Background:
Apis mellifera, European honey bee venom (BV) is a complex combination of chemical compounds
comprising proteins, peptides, enzymes, and other small molecules. Melittin (MEL), which is the key component of BV is
considered as an alternative for treatment of various infections. MEL is an amphipathic, cell-penetrating, 26-residue, ahelical anti-hepatoma peptide derived from BV. However, owing to its initial conformational strength and poor stability,
melittin is constrained in use as a medication.

Objective:
The study focused on collective data of therapeutic activities of Bee venom component, MEL.

Method:
Regardless of its broad variety of biological and possible therapeutic uses, there has been increasing concern in
the use of MEL. According to literature, MEL revealed range of activities started from Anti- cancer activity, Anti- microbial
activity, Anti- viral activity, Anti-inflammatory activity to Anti- diabetic activity. Present review article summarized
therapeutic applications of MEL, their mechanism of action along with recent research progress in field of its delivery.

Conclusion:
It could be concluded that MEL exerts multiple effects on cellular functions of infected cells.
Addressing Depression and Suicidality in the College Population
Authors: Alexander Amy W. , Morris Marcia , Chopra Mehak 
Published: December 2020

Background:
The need for mental health care among college students has grown exponentially
over the last decades; not only is the number of students needing care greater, but there is a
higher acuity as well. 19.9 million students are estimated to attend college in fall 2019. Relatively
few consensus guidelines exist on college mental health treatment and services.

Objective:
The aim of this study is to review the current understanding of depression and suicidality
in the college population, current treatment methods, and campus-wide systems considerations for
addressing these issues.

Method:
Review of current literature.

Results:
The increasing rates of depression and suicidality in the college student population have resulted
in increased morbidity and mortality, affecting college students and campuses across the country.
A comprehensive approach to address these issues includes treatment at an individual levelincluding
psychopharmacological treatment and various therapies, knowledge of campus and local
community resources, engaging students’ support systems including parents when appropriate, and
campus-wide systems approaches and interventions for reducing depression and increasing ease of
access to mental health services.

Conclusion:
A comprehensive and systems approach is necessary for addressing the increased rates
of depression and suicidality among college students.
Fault Detection in Power Distribution
Authors: Jhajharia Amarjeet , Kumari Uma , Chouhan Nitesh , Meena Yogesh 
Published: December 2020

Background :
In the present scenario, electricity theft is a major problem for the government.
This problem affects the Indian economy since GDP goes down due to theft. Electricity is a
part of living and its theft affects the common man who indirectly pays for the theft done by someone
else in the form of extra charges.

Methods:
In this paper, we present a novel identification pattern-based energy fault detector, by leveraging
the customers' normal and faulty line. The target of this paper was to implement a system to
monitor the readings and to find the fault in the power line in real time. Manipulations in readings of
the meter are impossible.

Results:
There is a real time monitoring of meters. Readings could be provided to customers on daily,
weekly, monthly or yearly basis. As soon as there occurs a fault, it could be rectified because
detection is on a real time basis and further messages can be sent to the customer about the fault.

Conclusion:
A comparison of developed real time monitoring system is done with GSM meters and
analog meters.
Cell Wall Components of Bacillus pumilus SE5 Improved the Growth, Digestive and Immunity of Grouper (Epinephelus coioides)
Authors: Yang Hong-Ling , Hu Xi , Ye Ji-Dan , Seerengaraj Vijayaram , Yang Wei , Ai Chun-Xiang , Sun Yun-Zhang 
Published: December 2020

Background::
Probiotic cellular components could be an interesting alternative to live
probiotics, which could potentially cause safety problems in open aquatic environments.

Objective::
The cell wall (CW), peptidoglycan (PG) and lipoteichoic (LTA) were extracted from
probiotic strain of Bacillus pumilus SE5, and these biomolecules were used to develop the possible
application in fish aquaculture.

Methods::
Grouper (Epinephelus coioides) juveniles were fed with either a basal control diet or the
basal diet supplemented with CW, PG and LTA respectively for 60 days, and the growth performance,
digestive enzymes activities, serum immune responses and immune genes expression in
head kidney were determined.

Results::
Dietary supplement PG and LTA significantly improved final body weight (FBW), weight
gain rate (WGR), specific growth rate (SGR) and protein efficiency ratio (PER), while significantly
decreased feed conversion ratio (FCR) was noticed in all the treatments compared with the control
group. Dietary supplements of CW, PG and LTA enhanced the activities of trypsin, lipase and amylase
in the liver. Serum complement C3 and IgM levels as well as, AKP, ACP and SOD activities
elevated significantly in fish fed the PG and LTA containing diets. Furthermore, PG and LTA containing
diets, significantly up-regulated expression of TLR2, NOD2, IL-8, IgM and three antibacterial
peptides genes (epinecidin-1, hepcidin-1 and β-defensin) in the head kidney.

Conclusion::
PG and LTA originated from probiotic B. pumilus SE5 could effectively enhance the
growth performance, feed utilization, digestive ability and boost innate and adaptive immune system
of E. coioides.
Reflecting on the Role of the Arctic Council vis-à-vis a Future International Legally Binding Instrument on Biodiversity in Areas Beyond National Jurisdiction
Authors: De Lucia Vito , Nickels Philip Peter 
Published: December 2020

Negotiations are ongoing to develop an international legally binding instrument (ILBI) under the United Nations Convention on the Law of the Sea (UNCLOS) on the conservation and sustainable use of marine biological diversity in areas beyond national jurisdiction (BBNJ). If adopted, the ILBI will likely apply to parts of the Arctic Ocean where the Arctic Council has played an important role for ocean governance. This begs the question of what role the Arctic Council will play vis-à-vis a future ILBI, which is envisioned to “not undermine existing relevant legal instruments and frameworks and relevant global, regional and sectoral bodies” (UN General Assembly Resolution 72/249). Against this backdrop, this article reflects on the future relationship between the Arctic Council and the ILBI. In so doing, the article initially discusses possible meanings of the notion of not undermining and, more broadly, how the ILBI will likely determine its institutional relationship with relevant bodies for BBNJ. Based on that, the article provides a short overview of the role of the Arctic Council in Arctic Ocean governance and explores whether the Arctic Council would qualify as a relevant regional body that shall not be undermined by the future ILBI.
Tumor de sistema nervoso central e o paciente pediátrico: alterações fonoaudiológicas
Authors: Silva Gabriela Pereira da , Palermo Rafaela Pagani , Etges Camila Lucia , Silva Roberta Alves da , Cardoso Maria Cristina de Almeida Freitas , Castro Junior Cláudio Galvão de , Barbosa Lisiane De Rosa 
Published: December 2020

Introdução: Os tumores do sistema nervoso central (SNC) constituem a segunda neoplasia mais frequente na criança. Os distúrbios tratados pela equipe de fonoaudiologia mais observados em pacientes com tumores são: disfagia, disfonia, alterações de linguagem, transtorno da articulação temporomandibular, disacusia, disartria e paralisia facial. A detecção precoce de alterações fonoaudiológicas em pacientes com tumores pediátricos, na fase do diagnóstico ou início do tratamento, é essencial para um manejo terapêutico mais adequado. Objetivo: descrever as alterações fonoaudiológicas de pacientes pediátricos com diagnóstico de tumor de sistema nervoso central em atendimento durante internação hospitalar. Método: Estudo retrospectivo, com coleta realizada através da pesquisa de dados extraídos de prontuário eletrônico, com dados dos pacientes internados de março de 2016 a agosto de 2018. Para avaliar a associação entre as variáveis categóricas, o teste Qui-quadrado de Pearson foi aplicado. O nível de significância adotado foi de 5% (p&#60;0,05). Resultados: Verificou-se maior relevância nos dados relacionados aos distúrbios de deglutição e motricidade orofacial. Observou-se significância estatística na variável local da lesão - em fossa posterior -, com presença de alterações fonoaudiológicas. Conclusão: A amostra de pacientes oncológicos pediátricos demonstrou alterações fonoaudiológicas, principalmente nas áreas de disfagia e de motricidade orofacial.
Metode Tafsir al-Baghawi dalam kitab Ma'a>lim al-Tanzi>l
Authors: Rohmanan Mohammad , Arminsa M. Lytto Syahrum 
Published: December 2020

AbstractMa'alim al-Tanzilby Al-Baghawi is a commentary book that has a concise explanation. Ma'alim al-Tanzil belongs to the commentary bookwhich is in the middle of the discussion, neither too long nor too short. The contents of the discussion are simple and not long winded. This paper wants to discuss about methodology, strenghts and weakness of the Tafsir Al-Baghawi. The method used in this paper is descriptive-analytic with the aim of further discussing and anlysing the interpretation method of the Qur’an used by Al-Baghawi in the book of interpretation. In carrying out the classification analysis, this paper discusses the Ridwan Nasir classification model. The conclusion resulting from this article is: seen from the sources of interpretation of Al-Baghawi inclined to use the bi al-Iqtiran method. For breadth of explanation, it falls into the category of interpretation of tafsiliy/it}nabiy. Lather, method of presenting interpretation resulting from the target and order of the verses that are transferred using the interpretation method tahlili. In addition, from several methods used, based on further reading, Tafsir Al-Baghawi has advantages and disadvantages. There fore, this paper only focuson the methodology, weakness and strengths side of the Tafsir Al-Baghawi. AbstrakMa'alim al-Tanzil karya Al-Baghawi merupakan kitab tafsir yang memiliki penjelasan yang ringkas. Ma'alim al-Tanzil tergolong kitab tafsir yang berada di tengah-tengah dalam pembahasannya, tidak terlalu panjang dan juga tidak terlalu pendek. Muatan pembahasannya terbilang sederhana dan tidak bertele-tele. Tulisan ini ingin membahas seputar metodologi, kelebihan dan kekurangan dari kitab Tafsir Al-Baghawi. Metode yang digunakan dalam tulisan ini deskriptif-analitik dengan tujuan mengeksplorasi dan menganalisis lebih jauh metode penafsiran al-Qur’an yang digunakan Al-Baghawi dalam kitab tafsirnya. Dalam melakukan klasifikasi analisis, tulisan ini mengacu pada model klasifikasi Ridwan Nasir. Kesimpulan yang dihasilkan dari artikel ini yaitu: dilihat dari sumber penafsiran, Al-Baghawi condong menggunakan metode tafsir bi al-Iqtiran. Untuk keluasan penjelasan masuk pada kategori tafsir tafsily/it}nabiy. Adapun metode penyajian tafsir yang dihasilkan dari sasaran dan tertib ayat yang ditafsirkan menggunakan metode tafsir tahlili. Selain itu, dari beberapa metode yang telah digunakan, berdasarkan pembacaan lebih lanjut, Tafsir Al-Baghawi memiliki kelebihan dan kekurangan. Oleh karena itu, tulisan ini hanya berfokus pada sisi metodologi, kekurangan dan kelebihan dari Tafsir Al-Baghawi. Kata Kunci: Tafsir Al-Baghawi, Metodologi, Kelebihan dan Kekurangan.
La Universidad Pública y su rol en la pandemia COVID-19: laboratorios de diagnóstico al servicio de la red nacional de laboratorios de influenza y otros virus respiratorios
Authors: Toro Rosana , Unzaga Juan Manuel , Marquez Gonzalo , Panei Javier , Bosch Alejandra , Docena Guillermo , Abba Martín Carlos , Hozbor Daniela 
Published: December 2020

La enfermedad por coronavirus 2019 (COVID-19) se informó por primera vez en Wuhan, China, el 31 de diciembre de 2019, declarándose emergencia de salud pública de importancia internacional en primera instancia y posteriormente elevada a la categoría de pandemia. Ante la grave situación sanitaria producto de la propagación del SARS-CoV-2, el Ministerio de Salud de la Provincia de Buenos Aires y la Universidad Nacional de La Plata establecieron un convenio de cooperación con la finalidad de que la Universidad Nacional de La Plata provea capacidad diagnóstica al sistema sanitario. Luego de un período de adecuación de los laboratorios e implementación de protocolos se inició tempranamente con el diagnóstico del SARS-CoV-2, habiendo procesado a fines de septiembre de 2020 más de 32.000 muestras provenientes de diversos Municipios de las Regiones Sanitarias I, II, IV, VI, X y XI de la Provincia de Buenos Aires. Los laboratorios participantes de las Facultades de Ciencias Exactas, Ciencias Médicas y Ciencias Veterinarias forman parte de los Laboratorios de referencia de COVID-19 de la Provincia de Buenos Aires y articulan dicha labor con diversas actividades de investigación, docencia y desarrollo con la finalidad de proveer soluciones al sistema de salud en el contexto de la pandemia. de salud en el contexto de la pandemia.