bluuebunny/crossref_metadata_2025_split huggingface dataset:
P282 Elevated serum uric acid associated with both electrocardiographic and echocardiographic left ventricular hypertrophy independent of blood pressure in healthy individuals
Authors: Liu C W , Chang W C , Pan R H 
Published: January 2020

Abstract

Funding Acknowledgements
TSGH 108-11

Background
Elevated serum uric acid (SUA) is associated with cardiac fibrosis and hypertrophy. A growing body of evidence showed the positive correlation between hyperuricemia (HUA) and left ventricular hypertrophy (LVH), but most studies defined LVH by a single method such as electrocardiogram or echocardiogram; the former is generally used in massive screen but the latter take advantage of the accuracy of LVH.

Purpose
We conducted this study to concomitantly investigate the association between SUA and electrocardiographic and echocardiographic LVH.

Methods
We initially enrolled 17,913 healthy individuals, who routinely underwent an annual health exam at our hospital between 2016/1/1∼2016/12/31. Of them, 347 individuals received transthoracic echocardiography because of abnormal results in their electrocardiogram. Amplitudes of 12-lead electrocardiogram were artificially measured by a study assistant under the supervision and by artificial intelligence. HUA is defined as an SUA level of ≥7 mg/dl in men and ≥6 mg/dl in women. Electrocardiographic LVH is defined by the criteria of Cornel voltage and product and Sokolow-Lyon and the Minnesota Code ECG classification. Echocardiographic LVH is defined by LV mass index ≥115g/m² in men or ≥95g/m² in women.

Results
The HUA group (n = 233) vs. normouricemic group (n = 114) was older and predominant male with greater values of body mass index, systolic and diastolic blood pressure and laboratory biomarkers, including non-high density total cholesterol, fasting glucose impairment, creatinine clearance, and haemoglobin. The two groups had comparable lifestyle choices, including tobacco use, alcohol intake, and physical activities per week. The HUA group compared with the normouricemic group had greater values of S amplitude of V1 plus R amplitude of V5 (3031 ± 2055 uV vs. 2566 ± 1021 uV, P = 0.005), R amplitude in lead I plus S amplitude in lead III (842 ± 443 uV vs. 696 ± 386 uV, P = 0.002) and LV mass index (95 ± 23 g/m² vs. 85 ± 30 g/m², P = 0.001). The prevalence of electrocardiographic and echocardiographic LVH was greater in the HUA group than the normouricemic group (7.0% vs. 2.1%, P = 0.034 for electrocardiographic LVH and 15.8% vs. 7.7%, P = 0.025 for echocardiographic LVH). In multivariate logistic regression analyses, elevated SUA was associated with LVH after the confounders were fully adjusted (OR: 1.38, 95% CI: 1.07-1.77, P = 0.012 for electrocardiographic LVH and OR: 1.58, 95% CI 1.15-2.17, P = 0.004 for echocardiographic LVH).

Conclusion
Elevated SUA is independently associated with the prevalence of both electrocardiographic and echocardiographic LVH in healthy individuals from Taiwan. Future studies might evaluate urate-lowering effects on the regression of LVH.
Surgical access trauma following minimally invasive thoracic surgery
Authors: Chan Joyce W Y , Yu Peter S Y , Yang Jack Hong , Yuan Evan Qize , Jia Hao , Peng Jia , Lau Rainbow W H , Ng Calvin S H 
Published: January 2020

SummarySurgical access trauma has important detrimental implications for immunological status, organ function and clinical recovery. Thoracic surgery has rapidly evolved through the decades, with the advantages of minimally invasive surgery becoming more and more apparent. The clinical benefits of enhanced recovery after video-assisted thoracoscopic surgery (VATS) may be, at least in part, the result of better-preserved cellular immunity and cytokine profile, attenuated stress hormone release and improved preservation of pulmonary and shoulder function. Parameters of postoperative pain, chest drain duration, hospital stay and even long-term survival are also indirect reflections of the advantages of reduced access trauma. With innovations of surgical instruments, optical devices and operative platform, uniportal VATS, robotic thoracic surgery and non-intubated anaesthesia represent the latest frontiers in minimizing trauma from surgical access.
Bacterial community profile after the lethal infection of Steinernema–Xenorhabdus pairs into soil-reared Tenebrio molitor larvae
Authors: Cambon Marine C , Lafont Pierre , Frayssinet Marie , Lanois Anne , Ogier Jean-Claude , Pagès Sylvie , Parthuisot Nathalie , Ferdy Jean-Baptiste , Gaudriault Sophie 
Published: January 2020

ABSTRACT
The host microbiota may have an impact on pathogens. This is often studied in laboratory-reared hosts but rarely in individuals whose microbiota looks like that of wild animals. In this study, we modified the gut microbiota of the insect Tenebrio molitor by rearing larvae in soil sampled from the field. We showed by high throughput sequencing methods that this treatment modifies the gut microbiota so that it is more diversified than that of laboratory-reared insects, and closely resembled the one of soil-dwelling insects. To describe what the entomopathogenic bacterial symbiont Xenorhabdus (Enterobacteriaceae), vectored by the soil-dwelling nematode Steinernema, might experience in natural conditions, we studied the infestation of the soil-reared T. molitor larvae with three Steinernema–Xenorhabdus pairs. We performed the infestation at 18°C, which delays the emergence of new infective juveniles (IJs), the soil-dwelling nematode forms, but which is a temperature compatible with natural infestation. We analyzed by high throughput sequencing methods the composition of the bacterial community within the insect cadavers before the first emergences of IJs. These bacterial communities were generally characterized by one or two non-symbiont taxa. Even for highly lethal Steinernema–Xenorhabdus pairs, the symbiont does not dominate the bacterial community within the insect cadaver.
Fast collocation for Moho estimation from GOCE gravity data: the Iran case study
Authors: Heydarizadeh Shali H , Sampietro D , Safari A , Capponi M , Bahroudi A 
Published: January 2020

SUMMARY
The study of the discontinuity between crust and mantle beneath Iran is still an open issue in the geophysical community due to its various tectonic features created by the collision between the Iranian and Arabian Plate. For instance in regions such as Zagros, Alborz or Makran, despite the number of studies performed, both by exploiting gravity or seismic data, the depth of the Moho and also interior structure is still highly uncertain. This is due to the complexity of the crust and to the presence of large short wavelength signals in the Moho depth. GOCE observations are capable and useful products to describe the Earth’s crust structure either at the regional or global scale. Furthermore, it is plausible to retrieve important information regarding the structure of the Earth’s crust by combining the GOCE observations with seismic data and considering additional information. In the current study, we used as observation a grid of second radial derivative of the anomalous gravitational potential computed at an altitude of 221 km by means of the space-wise approach, to study the depth of the Moho. The observations have been reduced for the gravitational effects of topography, bathymetry and sediments. The residual gravity has been inverted accordingly to a simple two-layer model. In particular, this guarantees the uniqueness of the solution of the inverse problem which has been regularized by means of a collocation approach in the frequency domain. Although results of this study show a general good agreement with seismically derived depths with a root mean square deviation of 6 km, there are some discrepancies under the Alborz zone and also Oman sea with a root mean square deviation up 10 km for the former and an average difference of 3 km for the latter. Further comparisons with the natural feature of the study area, for instance, active faults, show that the resulting Moho features can be directly associated with geophysical and tectonic blocks.
Art, Collaboration and Multi-Sensory Approaches in Public Microhistory: Journey with Absent Friends
Authors: Hammett Jessica , Harrison Ellie , King Laura 
Published: January 2020

Abstract
In this article we reflect upon the many advantages of collaborations between academic historians and artists, as a method for presenting our work, communicating with different audiences and, most importantly, beginning conversations which cause us to think about our research in new and creative ways. We argue that collaboration allows us to rethink the boundaries of expertise, it opens up both historical knowledge and the process of knowledge creation to different audiences in more egalitarian ways, and it provides innovative ways of doing historical research.
The Body Inside the Art and the Law of Marikana: A Case for Corporeality
Authors: Gill-Leslie Robyn 
Published: January 2020

ABSTRACT∞
This article positions the Marikana Commission of Inquiry as a transitional justice moment for South Africa. Using aesthetic and affect theory, the article examines instances of bodily engagement at this Commission and in the art related to it. The resultant foregrounding of physicality reveals the possibility of both resistance and conformity that has been overlooked in current arts and transitional justice literature. Such resistance and conformity, present inside both the law and the art of Marikana and its Commission, suggest that a binaristic approach to arts and transitional justice misses the full critical potential of each discipline. Softening the boundaries of each discipline through a corporeal approach can reveal different evaluations of the efficacy of transitional justice – in this case, challenging the efficacy of the Marikana Commission’s goal of stakeholder inclusion.
Settling Resistant Territorial Disputes: The Territorial Boundary Peace in Latin America
Authors: Schenoni Luis L , Goertz Gary , Owsiak Andrew P , Diehl Paul F 
Published: January 2020

AbstractWhy do some territorial disputes defy settlement? Through what mechanism might these resistant territorial disputes be settled? We propose that the answer involves three individually necessary and jointly sufficient conditions. First, the dispute must receive attention—i.e., be (re)placed and (re)prioritized on the dyad's agenda. Second, governments need altered preferences that expand the bargaining range so they can break deadlock and pursue settlement. Finally, disputing states need third-party assistance to facilitate, locate, incentivize, and support a settlement of their protracted dispute. We test this “AAA Model” in post–World War II Latin America. To do this, we first theorize the particular form of the general model; in post–1945 Latin America, attention, altered preferences, and third-party assistance operate through the mechanisms of militarization, democratization, and mediation respectively. We then identify resistant territorial disputes and advance a novel, multimethod research design to evaluate our hypotheses—one that relies more heavily on within-case counterfactual analysis. An extensive series of these counterfactual analyses, along with a statistical analysis, produce consistent, significant support for our model. When resistant territorial disputes in post–1945 Latin America have attention, altered preferences, and third-party assistance simultaneously, they always settle; when they lack any one factor, however, settlement never occurs.
Temporal condition pattern mining in large, sparse electronic health record data: A case study in characterizing pediatric asthma
Authors: Campbell Elizabeth A , Bass Ellen J , Masino Aaron J 
Published: January 2020

Abstract

Objective
This study introduces a temporal condition pattern mining methodology to address the sparse nature of coded condition concept utilization in electronic health record data. As a validation study, we applied this method to reveal condition patterns surrounding an initial diagnosis of pediatric asthma.

Materials and Methods
The SPADE (Sequential PAttern Discovery using Equivalence classes) algorithm was used to identify common temporal condition patterns surrounding the initial diagnosis of pediatric asthma in a study population of 71 824 patients from the Children’s Hospital of Philadelphia. SPADE was applied to a dataset with diagnoses coded using International Classification of Diseases (ICD) concepts and separately to a dataset with the ICD codes mapped to their corresponding expanded diagnostic clusters (EDCs). Common temporal condition patterns surrounding the initial diagnosis of pediatric asthma ascertained by SPADE from both the ICD and EDC datasets were compared.

Results
SPADE identified 36 unique diagnoses in the mapped EDC dataset, whereas only 19 were recognized in the ICD dataset. Temporal trends in condition diagnoses ascertained from the EDC data were not discoverable in the ICD dataset.

Discussion
Mining frequent temporal condition patterns from large electronic health record datasets may reveal previously unknown associations between diagnoses that could inform future research into causation or other relationships. Mapping sparsely coded medical concepts into homogenous groups was essential to discovering potentially useful information from our dataset.

Conclusions
We expect that the presented methodology is applicable to the study of diagnostic trajectories for other clinical conditions and can be extended to study temporal patterns of other coded medical concepts such as medications and procedures.
An evaluation of the economic effects of bovine respiratory disease on animal performance, carcass traits, and economic outcomes in feedlot cattle defined using four BRD diagnosis methods
Authors: Blakebrough-Hall Claudia , McMeniman Joe P , González Luciano A 
Published: January 2020

AbstractBovine respiratory disease (BRD) causes significant economic losses to the feedlot industry due to decreased production and increased costs associated with treatment. This study aimed to assess the impacts of BRD on performance, carcass traits, and economic outcomes defined using four BRD diagnosis methods: number of BRD treatments an animal received, pleural lesions at slaughter, lung lesions at slaughter, and clinical BRD status defined using both treatment records and lung and pleural lesions. Crossbred steers (n = 898), with an initial body weight of 432 kg (± SD 51), were followed from feedlot entry to slaughter. Veterinary treatment records were collected and lungs scored at slaughter for lesions indicative of BRD. There was an 18% morbidity rate and a 2.1% BRD mortality rate, with an average net loss of AUD$1,647.53 per BRD mortality. Animals treated ≥3 times for BRD had 39.6 kg lighter carcasses at slaughter and returned an average of AUD$384.97 less compared to animals never treated for BRD (P &lt; 0.001). Animals with severe lung lesions at slaughter grew 0.3 kg/d less, had 14.3 kg lighter carcasses at slaughter, and returned AUD$91.50 less than animals with no lung lesions (P &lt; 0.001). Animals with subclinical and clinical BRD had 16.0 kg and 24.1 kg lighter carcasses, respectively, and returned AUD$67.10 and AUD$213.90 less at slaughter, respectively, compared to healthy animals that were never treated with no lesions (P &lt; 0.001). The severity of BRD based on the number of treatments an animal received and the severity of lung and pleural lesions reduced animal performance, carcass weight and quality, and economic returns. Subclinical BRD reduced animal performance and economic returns compared to healthy animals; however, subclinical animals still had greater performance than animals with clinical BRD. This information can be used to plan for strategic investments aimed at reducing the impacts of BRD in feedlot cattle such as improved detection methods for subclinical animals with lesions at slaughter and BRD treatment protocols.
Translation and Cross-cultural Validation of the English Young Adult Burn Outcome Questionnaire (YABOQ) in Spanish
Authors: Brady Keri J S , Ni Pengsheng , Grant Gabrielle G , Thorpe Catherine R , Nadler Deborah , Lee Austin , Shapiro Gabriel D , Kogosov Ann , Palmieri Tina L , Tompkins Ronald G , Schneider Jeffrey C , Kazis Lewis E , Ryan Colleen M 
Published: January 2020

Abstract
The Young Adult Burn Outcome Questionnaire (YABOQ) is a validated, English-language patient-reported outcome assessment of young adults’ recovery from burn injury across 15 scale domains. We evaluated the cross-cultural validity of a newly developed Spanish version of the YABOQ. Secondary data from English- and Spanish-speaking burn survivors (17 to 30 years of age) were obtained from the Multicenter Benchmarking Study. We conducted classic psychometric analyses and evaluated the measurement equivalence of the English and Spanish YABOQs in logistic and ordinal logistic regression differential item functioning analyses. All multi-item scales in the Spanish YABOQ demonstrated adequate reliability except the Pain and Itch scales. One item in the Perceived Appearance scale showed differential item functioning across English- and Spanish-speaking burn survivors, but the observed differential item functioning had no clinically significant impact on scale-level Perceived Appearance scores. Our findings support the cross-cultural validity of the YABOQ Physical Function, Perceived Appearance, Sexual Function, Emotion, Family Function, Family Concern, Satisfaction with Symptom Relief, Satisfaction with Role, Work Reintegration and Religion scales among English- and Spanish-speaking young adult burn survivors. This work supports the use of these English and Spanish YABOQ scales to assess the effect of therapeutic interventions on young adults’ burn outcomes in pooled analyses and to assess disparities in young adults’ burn outcomes across language groups.
Aluminium–silicon interactions in higher plants: an update
Authors: Hodson Martin J , Evans David E 
Published: January 2020

Abstract
Aluminium (Al) and silicon (Si) are abundant in soils, but their availability for plant uptake is limited by low solubility. However, Al toxicity is a major problem in naturally occurring acid soils and in soils affected by acidic precipitation. When, in 1995, we reviewed this topic for the Journal of Experimental Botany, it was clear that under certain circumstances soluble Si could ameliorate the toxic effects of Al, an effect mirrored in organisms beyond the plant kingdom. In the 25 years since our review, it has become evident that the amelioration phenomenon occurs in the root apoplast, with the formation of hydroxyaluminosilicates being part of the mechanism. A much better knowledge of the molecular basis for Si and Al uptake by plants and of Al toxicity mechanisms has been developed. However, relating this work to amelioration by Si is at an early stage. It is now clear that co-deposition of Al and Si in phytoliths is a fairly common phenomenon in the plant kingdom, and this may be important in detoxification of Al. Relatively little work on Al–Si interactions in field situations has been done in the last 25 years, and this is a key area for future development.
The High Time Resolution Universe Pulsar Survey – XVI. Discovery and timing of 40 pulsars from the southern Galactic plane
Authors: Cameron A D , Champion D J , Bailes M , Balakrishnan V , Barr E D , Bassa C G , Bates S , Bhandari S , Bhat N D R , Burgay M , Burke-Spolaor S , Flynn C M L , Jameson A , Johnston S , Keith M J , Kramer M , Levin L , Lyne A G , Ng C , Petroff E , Possenti A , Smith D A , Stappers B W , van Straten W , Tiburzi C , Wu J 
Published: January 2020

ABSTRACT
We present the results of processing an additional 44  per cent of the High Time Resolution Universe South Low Latitude (HTRU-S LowLat) pulsar survey, the most sensitive blind pulsar survey of the southern Galactic plane to date. Our partially coherent segmented acceleration search pipeline is designed to enable the discovery of pulsars in short, highly accelerated orbits, while our 72-min integration lengths will allow us to discover pulsars at the lower end of the pulsar luminosity distribution. We report the discovery of 40 pulsars, including three millisecond pulsar-white dwarf binary systems (PSRs J1537−5312, J1547−5709, and J1618−4624), a black-widow binary system (PSR J1745−23) and a candidate black-widow binary system (PSR J1727−2951), a glitching pulsar (PSR J1706−4434), an eclipsing binary pulsar with a 1.5-yr orbital period (PSR J1653−45), and a pair of long spin-period binary pulsars which display either nulling or intermittent behaviour (PSRs J1812−15 and J1831−04). We show that the total population of 100 pulsars discovered in the HTRU-S LowLat survey to date represents both an older and lower luminosity population, and indicates that we have yet to reach the bottom of the luminosity distribution function. We present evaluations of the performance of our search technique and of the overall yield of the survey, considering the 94  per cent of the survey which we have processed to date. We show that our pulsar yield falls below earlier predictions by approximately 25  per cent (especially in the case of millisecond pulsars), and discuss explanations for this discrepancy as well as future adaptations in RFI mitigation and searching techniques which may address these shortfalls.
A new and unusual LBV-like outburst from a Wolf–Rayet star in the outskirts of M33
Authors: Smith Nathan , E Andrews Jennifer , Moe Maxwell , Milne Peter , Bilinski Christopher , Kilpatrick Charles D , Fong Wen-Fai , Badenes Carles , Filippenko Alexei V , Kasliwal Mansi , Silverman Jeffrey M 
Published: January 2020

ABSTRACT
MCA-1B (also called UIT003) is a luminous hot star in the western outskirts of M33, classified over 20 yr ago with a spectral type of Ofpe/WN9 and identified then as a candidate luminous blue variable (LBV). Palomar Transient Factory data reveal that this star brightened in 2010, with a light curve resembling that of the classic LBV star AF And in M31. Other Ofpe/WN9 stars have erupted as LBVs, but MCA-1B was unusual because it remained hot. It showed a WN-type spectrum throughout its eruption, whereas LBVs usually get much cooler. MCA-1B showed an almost four-fold increase in bolometric luminosity and a doubling of its radius, but its temperature stayed ≳29 kK. As it faded, it shifted to even hotter temperatures, exhibiting a WN7/WN8-type spectrum, and doubling its wind speed. MCA-1B is reminiscent of some supernova impostors, and its location resembles the isolated environment of SN 2009ip. It is most similar to HD 5980 (in the Small Magellanic Cloud) and GR 290 (also in M33). Whereas these two LBVs exhibited B-type spectra in eruption, MCA-1B is the first clear case where a Wolf–Rayet (WR) spectrum persisted at all times. Together, MCA-1B, HD 5980, and GR 290 constitute a class of WN-type LBVs, distinct from S Doradus LBVs. They are most interesting in the context of LBVs at low metallicity, a possible post-LBV/WR transition in binaries, and as likely Type Ibn supernova progenitors.