bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of Pharmacists’ Reported Interventions to Prevent Prescribing Errors among in Hospital Inpatients: A Cross Sectional Retrospective Study
Authors: Alzahrani Abdulhakim , Alwhaibi Monira , Asiri Yousif , Kamal Khalid , Alhawassi Tariq 
Published: March 2020

Abstract
Background: Prescribing errors (PEs) are a common cause of morbidity and mortality, both in community practice and in hospitals. Pharmacists have an essential role in minimizing and preventing PEs, thus, there is a need to document the nature of pharmacists’ interventions in preventing PEs. The purpose of this study was to describe reported interventions conducted by pharmacists that to prevent or minimize PEs in a tertiary care hospital. Methods: A retrospective analysis of the electronic medical records data was conducted to identify pharmacists’ interventions related to reported PEs. The PE-related data was extracted for a period of six-month (April to September 2017) and comprised of patient demographics, medication-related information, and the different interventions by the pharmacists. The study was conducted in a tertiary care hospital in Riyadh region. The study was ethically reviewed and approved by the hospital IRB committee. Descriptive analyses were appropriately conducted using the IBM SPSS Statistics. Results: A total of 2,564 pharmacists’ interventions related to PEs were recorded. These interventions were reported in 1,565 patients. Wrong dose (54.3%) and unauthorized prescription (21.9%) were the most commonly encountered PEs. Anti-infectives for systemic use (49.2%) and alimentary tract and metabolism (18.2%) were the two most common medications, which involved PEs. Most commonly reported pharmacists’ interventions included dose adjustments (44.0%), restricted medication approvals (21.9%), and therapeutic duplications (11%). Conclusions: PEs occur commonly in hospitals and pharmacists’ interventions are critical is preventing possible harm to patients. Care coordination and prioritizing patient safety through quality improvement initiatives at all levels of the health care system can play a key role in this quality improvement drive. Future studies should evaluate the impact of pharmacists’ interventions on patient outcomes.
Costs and Effectiveness of a Culturally Tailored Communication Training Program to Increase Cultural Competence Among Multi-Disciplinary Care Management Teams
Authors: Parker Brenda Marie , Fang Xiangming , Bradlyn Andrew S 
Published: March 2020

Abstract
Background. Several studies have demonstrated that cultural competence improves patient-provider communication, which promotes adherence to established care plans and improves patient satisfaction and health outcomes. However, there is very little data available regarding the costs associated with the development and implementation of cultural competence training, or the cost-effectiveness of these programs. To that end, this evaluation aims to describe programmatic effectiveness, cost, and cost-effectiveness of a culturally tailored communication training program to improve cultural competence among multi-disciplinary care management teams.Methods. As part of a region-wide quality improvement initiative to reduce healthcare disparities among African American patients with uncontrolled hypertension, three multi-disciplinary care management teams were invited to participate in a two-part communication training program. A paired samples t-test was used to assess program effectiveness based on participant responses to a validated cultural competence self-assessment survey two weeks before and after the training program. A micro-costing approach was used to estimate programmatic costs for content development and delivery. Cost-effectiveness was then determined using the average cost-effectiveness ratio, and sensitivity analyses were conducted to assess the impact of participant mix on this result.Results. All scores (n=17) improved after training; however, only the culturally competent behaviors (CCB) subscale change was statistically significant (p=0.02). Overall program costs were $5,754.19. The average program cost per participant was $138.51, with an ACER of $337.83 per 1-unit increase in CCB score. Sensitivity analyses yielded a range of ACERs between $122.59 and $457.07, where all participants are support staff and nurses, respectively.Conclusions. Culturally tailored communication training increases how frequently participants demonstrate culturally competent behaviors and may be a cost-effective intervention for care management teams to address individual cultural competence. Detailed costs associated with cultural competence training are largely unavailable in the literature; as such, these data may serve as a financial framework for organizations considering the implementation of similar programs.
Relationship of Breastfeeding Duration with Joint Pain and Knee Osteoarthritis in Middle-aged Korean Women: A Cross-sectional Study using the Korea National Health and Nutrition Examination Survey
Authors: Kim Min-Young , Kim Hyun-Joong , Noh Je-Heon , Kim Sun-A , Hwang Deok-Sang , Lee Chang-Hoon , Ha In-Hyuk 
Published: March 2020

Abstract
Background The effect of joint health on quality of life in middle-aged and older women is becoming more widely recognized with the aging of the world’s population. However, the association of long-term breastfeeding with joint pain and knee osteoarthritis has not been fully examined. The aim of this study was to determine the association of long-term breastfeeding with joint pain and knee osteoarthritis in middle-aged Korean women. Methods A cross-sectional study was conducted among 3,454 women aged ≥50 years who underwent knee radiography and answered a questionnaire on breastfeeding and joint pain for the 5 th Korean National Health and Nutrition Examination Survey (2010–2011). After adjusting for confounding sociodemographic, medical history, and obstetric and gynecologic variables, logistic regression analysis was conducted to analyze the incidence of joint pain and knee osteoarthritis according to breastfeeding and its duration. Among the 3,454 participants, 298 had not breastfed and 1,042, 815, and 1,299 had breastfed for 1–24, 25–48, and ≥49 months, respectively. Of all participants, 1,731 had joint pain and 739 were diagnosed with knee osteoarthritis after radiography. Results The odds ratio (OR) for joint pain among women who breastfed was 1.493 times higher than that among women who did not (p=0.044). As breastfeeding duration increased, the OR of joint pain incidence also increased (p for trend; p=0.002). For knee osteoarthritis, the OR was significantly different between the 25–48 and ≥49 months groups (2.299 [p=0.03] and 2.166 [p=0.047], respectively). Reanalysis after selecting only participants aged ≥60 years showed that the prevalence of joint pain and knee osteoarthritis was more positively correlated with extended breastfeeding duration (joint pain, p for trend; p=0.005) (knee osteoarthritis, p for trend; p=0.012). Conclusions Long-term feeding of more than 25 months was associated with an increased prevalence of arthralgia and degenerative arthritis after menopause in Korean elderly women.
Spatio-temporal impact of self-financed Rotavirus vaccination on Rotavirus and acute gastroenteritis hospitalisations in the Valencia Region, Spain
Authors: López-Lacort Mónica , Orrico-Sánchez Alejandro , Martínez-Beneito Miguel Ángel , Muñoz-Quiles Cintia , Díez-Domingo Javier 
Published: March 2020

Abstract
Background Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a dynamic and complex space-time process. Therefore, there is a need to analyse the impact of RV vaccination on RV and AGE hospitalisations in a space-time framework to detect geographical-time patterns while avoiding the potential confusion caused by population inequalities in the impact estimations. Methods A retrospective population-based study using real-world data from the Valencia Region was performed among children aged less than 3 years old in the period 2005-2016. A Bayesian spatio-temporal model was constructed to analyse RV and AGE hospitalisations and to estimate the vaccination impact measured in averted hospitalisations. Results We found important spatio-temporal patterns in RV and AGE hospitalisations, RV vaccination coverage and in their associated adverted hospitalisations. Overall, ~1866 hospital admissions for RV were averted by RV vaccination during 2007–2016. Despite the low-medium vaccine coverage (~50%) in 2015-2016, relevant 36% and 20% reductions were estimated in RV and AGE hospitalisations respectively. Conclusions The introduction of the RV vaccines has substantially reduced the number of RV hospitalisations, averting ~1866 admissions during 2007-2016 which were space and time dependent. This study improves the methodologies commonly used to estimate the RV vaccine impact and their interpretation.
Co-regulation role of endogenous hormones and transcriptomics profiling under cold stress in Tetrastigma hemsleyanum
Authors: Peng Xin , Qiu Wenyu , Li Mingjie , Wu Hao , Chen Hongjiang , Zhang Zhongyi 
Published: March 2020

Abstract
Background: Tetrastigma hemsleyanum Diels et Gilg is a valuable medicinal herb, Chilling sensitivity is the dominant environmental factor limiting the artificial domestication of the plant. Hormone-related gene regulation and hormone signaling pathways in response to cold stress in T. hemsleyanum remain unknown. Results: Some key genes involved in hormones biosynthesis, such as ZEP and NCED genes of ABA biosynthesis, GA2ox, GA3ox, and GA20ox genes of GA biosynthesis, ACO genes of ET biosynthesis pathway were screened to be crucial in cold response. Consistently, the response of ABA and ABA/GA1+3 to cold stress was prior to that of GA1+3, ZR, ABA/IAA, and ABA/ZR. The increasing changes in ABA/GA1+3 turned to a steep decline with the extension of stress time, which might be one factor contributing to cold-sensitivity of T. hemsleyanum under prolonged stress. The cold tolerance of T. hemsleyanum would be enhanced by ABA but repressed by GA3 when each phytohormone was applied alone. The ABA-mediated promotion and GA-mediated repression of cold tolerance could both be attenuated by the co-application of the two phytohormones within 6h. When the biosynthesis of endogenous ABA and GA were inhibited by FLU and PAC, respectively, the effects of GA and ABA treatment were reversed partially. Conclusions: In summary, we presented the ﬁrst study of global expression patterns of hormone-regulated transcripts in T. hemsleyanum. This study suggested that GA and ABA could work antagonistically to balance the responses to cold in T. hemsleyanum. PAC, a GA biogenesis inhibitor, as well as exogenous ABA, might be potential plant growth regulators that can promote cold tolerance of T. hemsleyanum. The study also provided valuable hints in revealing a new theoretical basis and potential candidate genes that govern cold tolerance of T. hemsleyanum.
Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigs
Authors: Ma Cheng , Khederzadeh Saber , Adeola Adeniyi C. , Han Xu-Man , Xie Hai-Bing , Zhang Ya-Ping 
Published: March 2020

Abstract
Background: Polydactyly is one of the most common congenital limb dysplasia in many animal species. Although preaxial polydactyly (PPD) has been comprehensively studied in humans as a common abnormality, the genetic variations in other animals have not been fully understood. Herein, we focused on the pig, as an even-toed ungulate mammal model with its unique advantages in medical and genetic researches, two PPD families consisting of four affected and 20 normal individuals were sequenced.Results: Our results showed that the PPD in the sampled pigs were not related to the variants reported in earlier studies. A strong association was identified at ABCC4 and it encodes a transmembrane protein involved in ciliogenesis. We found that the affected and normal individuals were highly differentiated at ABCC4, and all the PPD individuals shared long haplotype stretches as compared with the unaffected individuals. A highly differentiated missense mutation (I85T) in ABCC4 was observed at a residue from a transmembrane domain highly conserved among a variety of organisms.Conclusions: This study reports ABCC4 as a new candidate gene for PPD in pigs and identifies a missense mutation. Our results illustrate a putative role of ciliogenesis process in PPD, coinciding with an earlier observation of ciliogenesis abnormality resulting in pseudo-thumb development in pandas. These results expand our knowledge on the genetic variations underlying PPD in animals.
Maternal Morbidity and Co-morbidity During and After Pregnancy in Women in Low- and Middle-Income Countries: A Systematic Literature Review
Authors: McCauley Mary , Zafar Shamsa , Broek Nynke van den 
Published: March 2020

Abstract
BackgroundFor every maternal death, it is estimated that 20 or 30 women have morbidity related to pregnancy or childbirth. The majority of this burden of disease is in women living in low and middle income countries. Maternal morbidity includes physical, psychological and social ill-health. There is limited data on the strength of association between these co-morbidities. In order to address all health needs that a woman may have when attending for maternity care, it is important to be able to identify all types of co-morbidities and understand how each co-morbidity influences other aspects of a woman’s health and wellbeing during and after pregnancy.MethodsWe systematically reviewed published literature, in English, describing measurement of two or more types of maternal morbidity, and/or associations between co-morbidities, during or after pregnancy and childbirth for women living in low- and middle-income countries. CINAHL plus, Global Health, Medline and Web of Science databases were searched from 2007-2018. Outcomes were descriptions, occurrence of maternal co-morbidities, and associations between these co-morbidities. Narrative analysis was conducted.Results38 papers reporting on 36 studies were included (71,229 women; 60,911 during and 10,318 after pregnancy from 17 countries). The majority of studies (26/36) were cross-sectional surveys. Self-reported physical ill-health was documented in 26 studies but there was no standardised data collection tool used. In total, physical morbidity was included in 28 studies; psychological morbidity in 32 studies and social morbidity in 27 studies; with 3 studies assessing association between all three types of morbidity and 30 studies assessing association between two types of morbidity. In four studies, clinical examination and/or basic laboratory investigations were also conducted. There is reported association between physical and psychological morbidity (four studies); and association between psychological and social morbidity (six studies). Domestic violence increases risk of physical ill-health (two studies).ConclusionsThere is a lack of standardised, comprehensive and routine measurements and tools used to assess the burden maternal morbidity and co-morbidity in women during and after pregnancy. There is emerging data to suggest strong associations between the different types of morbidity.
A Review of Multi-dimensional Diagnosis of Alport Syndrome in 22 Children in Northeast China
Authors: Zhang Li , Sun Bai-chao , Zhao Bing-gang , Ma Qing-shan 
Published: March 2020

Abstract
Background Alport syndrome (AS) is progressive hereditary nephritis due to different gene mutations. Affected individuals usually develop hematuria during childhood with gradual deterioration of renal functions. We adopted multi-dimensional methods to diagnose Alport syndrome in order to decrease the misdiagnosis.Methods Twenty-two children were diagnosed and managed by the Department of Pediatric Nephrology of Jilin University First Hospital between January 2017 and January 2020 through multi-dimensional methods. Information collected included age of onset, age at diagnosis, clinical manifestations, family history (FH), renal pathology and their genotype. Results All patients presented with hematuria with various degrees of proteinuria in partial patients. While three children suffered from hearing loss, none of the children in the cohort had any visual problem or renal failure. Besides five patients estimated as Stage 2, the remain seventeen cases were at Stage 0. Renal biopsy were obtained in eighteen patients and fourteen of them showed glomerular basement membranes (GBM)-specific abnormalities. Thirteen children had mutations of the collagen IV genes.Conclusion Combined with the importance of early diagnosis and economic factors, we adopted multi-dimensional methods to diagnose Alport syndrome and estimate the risk of progression. We also reviewed the therapy progress.
Examining Innovation in Hospital Units: A Complex Adaptive Systems Approach
Authors: Glover Wiljeana , Nissinboim Noa , Naveh Eitan 
Published: March 2020

Abstract
Background: Health innovation has been dominant in the pharmaceutical, biomedical, and to some extent insurance institutions for quite some time. Now we are in an innovation age for healthcare delivery. Some note that the complexity of healthcare delivery may make innovation in this setting more difficult and may require more adaptive solutions. The aim of this study is to examine the relationship between departmental complexity and innovation, using a complex adaptive systems approach in a hospital setting. Methods: We conducted a quantitative study of 31 hospital units within one hospital and use complex adaptive systems (CAS) theory to examine how two CAS factors, autonomy and performance orientation, moderate the relationship between departmental complexity and innovation. Results: We find that departmental complexity is associated with higher innovation performance when autonomy is low rather than high. We also find that departmental complexity is associated with higher innovation performance when performance orientation is high rather than low. Our findings make three distinct contributions: we quantify the influence of complexity on innovation success in the health care sector, we examine the impact of autonomy on innovation in health care, and we are the first to examine performance orientation on innovation in health care. Conclusions: This study tackles the long debate about the influence of complexity on healthcare delivery, particularly innovation. Instead of being subject to the influence of complexity with no means of making progress or gaining control, hospitals looking to implement innovation programs should provide guidance to teams and departments regarding the type of innovation sought and provide support in terms of time and management commitment. Hospitals should also find ways to promote and make successful pilot implementations of such innovations visible in the organization. A close connection between the targeted innovation and the overall success and performance of the hospital unit is ideal.
Developing and implementing guidelines on culturally adapting cognitive tests: A qualitative illustration with the Addenbrooke’s Cognitive Examination Version III (ACE-III)
Authors: Waheed Waquas , Mirza Nadine , Waheed Muhammed Wali , Malik Abid , Panagioti Maria 
Published: March 2020

Abstract
Background: We aimed to devise a methodology on developing and implementing guidelines for culturally adapting any cognitive test. We demonstrated this through developing guidelines for culturally adapting the Addenbrooke’s Cognitive Examination Version III (ACE-III) and utilising them to develop an ACE-III Urdu for a British South Asian population. Methods: We had a several stage qualitative study. We collated information from our systematic review on the translation and cultural adaptation of the ACE-III and its predecessors, and feedback from previous adaptors of the ACE-III to identify steps for cultural adaptation. We formatted these into question-by-question guidelines. These guidelines were used with feedback from focus groups with cognitively healthy older British South Asians and a consensus meeting with relevant experts, to develop an ACE-III Urdu. Results: Our systematic review found 32 adaptations and we received feedback from seven adaptors to develop guidelines for culturally adapting the ACE-III. Through the use of these guidelines, two focus groups with 12 participants, and a consensus meeting of two psychiatrists with a South Asian background and familiarity with cognitive assessments and cultural adaptation, the ACE-III Urdu was developed. Conclusions: We developed a set of guidelines for culturally adapting the ACE-III that can be used by future adapters for their own language or cultural context. We demonstrated how guidelines on cultural adaptation can be developed for any cognitive test and how they can be used to culturally adapt the measure.
Internet addiction mediates the association between cyber victimization and psychological and physical symptoms：moderation by physical exercise
Authors: Lin Ling , Liu Jianbo , Cao Xiaolan , Wen Siying , Xu Jianchang , Xue Zhenpeng , Lu Jianping 
Published: March 2020

Abstract
Background: The potential mechanisms underlying cyber victimization and the resulting psychological and physical symptoms remain unclear. Thus, the present study investigated whether Internet addiction mediates the association between peer victimization (e.g., cyberbullying) and psychological and physical symptoms. Furthermore, it was assessed whether physical exercise moderates the hypothetical mediation.Methods: 1,854 students from 11 middle and high schools in Shenzhen, Guangdong Province, China, were sampled for this study. Psychological and physical symptoms were assessed using the World Health Organization Quality of Life-BREF, while Internet addiction was evaluated using the Internet addiction test by Young. Cyber victimization was measured using a single question. In addition, this study examined whether Internet addiction mediated the association between cyber victimization and both psychological and physical symptoms. Additional work was conducted to test if physical exercise played a moderating role in the mediation hypothesized above. Mediation and moderation were analyzed using PROCESS macro for SPSS.Results: Regression analysis showed that both cyber victimization (β = -0.102, p < 0.05) and Internet addiction (β = -0.278, p < 0.05) significantly predicted psychological and physical symptoms and demographic variables were controlled. Further mediation analysis suggested that Internet addiction mediated the relationship between cyber victimization and psychological and physical symptoms. The 95% confidence interval of the direct effect was (-4.283, -1.696) and the indirect effect (­–1.904, -0.820), respectively, excluding zero. Finally, moderation analysis indicated that physical exercise moderated the relationship between Internet addiction and psychological and physical symptoms (p = 0.047).Conclusions: Internet addiction plays a mediating role in the association between cyber victimization and both psychological and physical symptoms, Thus, addressing Internet addiction among cyberbullying victims is worthwhile. Furthermore, physical exercise alleviates negative impacts on health and should thus be promoted.