bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Survival Prediction Model for Patients with Synchronous Colorectal Carcinomas Based on SEER
Authors: Xu YuXin , Wang XiaoJie , Huang Ying , Ye DaoXiong , Chi Pan 
Published: April 2020

Abstract
Introduction

The nomogram for postoperative prediction of overall survival (OS) in patients’ synchronous colorectal carcinomas (SCC) was developed and validated by LASSO regression combined with COX regression.

Methods

The data was obtained from the SEER database of patients diagnosed with colorectal cancer (CRC) more than one time between 2004 and 2013. The cut-off points for the continuous variable were identified by the K-adaptive partitioning algorithm and x-tile software. Using LASSO regression combined with the Cox regression, a model for predicting the overall survival of SCC was built, internally and externally validated, and measured through a calibration curve, C-index, AIC, BIC, IDI, NRI, timeROC, timeAUC, and decision curve analysis (DCA), and results compared to the model developed by the Cox regression.

Results

Patients with SCC were found to be older, more often men, and likely to have a depth of invasion by T3. In addition, there were no significant differences between the model developed by LASSO regression combined with Cox regression and the Cox regression in the calibration curve, C-index, AIC, BIC, IDI, NRI, timeROC, and DCA. Besides, the model developed by LASSO regression combined with Cox regression was found to perform better than the Cox regression in the timeAUC. Moreover, the model developed by LASSO regression combined with Cox regression showed good calibration, C-index, AIC, BIC, IDI, NRI, timeROC, timeAUC and had a larger net benefit compared to both the first time TNM staging and the combination of two times TNM staging.

Discussion

This present study indicates that a close follow-up of older patients, male, and T3 should be made. LASSO regression combined with COX regression decreases the variables of the model, avoids overfitting and collinearity and has clinical significance.
High-risk factors for ipsilateral lateral neck lymph node metastasis in clinically node-negative patients with papillary thyroid microcarcinoma (cT1aN0)
Authors: ZHOU BIN , WEI LIN , QIN JIANWU 
Published: April 2020

Abstract
Background: The incidence of papillary thyroid microcarcinoma (PTMC) increases yearly. There are several studies on the high-risk factors for lymph node metastasis in the central compartment of PTMC but few studies on the high-risk factors for lateral neck lymph node (LNLN) metastasis. Few studies have analyzed the high-risk factors for LNLN metastasis for clinically lymph node-negative PTMC patients in stage T1a (cT1aN0). We investigated the risk factors for LNLN metastasis in these patients.Methods: In total, 127 PTMC (cT1aN0) patients underwent hemi- or total thyroidectomy with ipsilateral central lymph node dissection (CLND) plus lateral lymph node dissection (LLND), including levels III and IV, between 2018 and 2019 in our hospital. Univariate and multivariate analyses identified the high-risk factors for LNLN metastasis in PTMC (cT1aN0).Results: The rate of LNLN metastasis was 21.26% (27/127). The multivariate analysis showed that capsular invasion (p=0.027), tumor location at the superior pole (p=0.002) and ipsilateral central lymph node positivity (p=0.001) were independent risk factors for LNLN metastasis in PTMC patients (cT1aN0), with odds ratios (ORs) of 0.181 (95% confidence interval (95% CI): 0.039-0.827), 5.994 (95% CI: 1.949-18.435) and 6.182 (95% CI: 2.193-17.425), respectively.Conclusions: These findings indicate that capsular invasion, tumor location at the superior pole and ipsilateral central lymph node positivity are independent high-risk factors for LNLN metastasis in clinically node-negative PTMC (cT1aN0) patients. High-risk factors should be correctly evaluated to guide surgical treatment for PTMC patients.
Evidence for circulating microRNA hsa-let-7d-3p as a potential new biomarker for sepsis in human subject
Authors: Zhang Zhaorui , Luo Hailun , Li Chunsun , Liang Zhixin 
Published: April 2020

Abstract
Background: Current biomarkers for early detection of sepsis have low sensitivity and specificity. Serum microRNAs (miRNAs) have been proposed as novel non-invasive biomarkers for various diseases. The aim of the present study was to discover a novel diagnostic biomarker for sepsis in human subjects. Methods: miRNA expression profile was performed using peripheral blood from three sepsis patients in sepsis stage and condition improved stage using microarray screening. The differentially expressed miRNAs were primary validated by real-time quantitative polymerase chain reaction (qRT-PCR) in a further set of 20 sepsis patients in the sepsis stage and condition improved stage. We finally validate the different expressed miRNA in 95 sepsis patients and 66 non sepsis patients. The validated miRNAs along with patients’ clinical indictors were analyzed in a multivariate logistic regression model. The diagnosis value of the changed miRNA in sepsis was determined and compared with CRP and WBC by analyzing the receiver operating characteristic (ROC) curves. Results: According to the criteria we detected 3 miRNAs up regulated and 8 miRNAs down regulated by miRNA chip. qRT-PCR detection showed that the expression of hsa-let-7d-3p in sepsis patient was up regulated compared with non-sepsis patients. In a multiple logistic regression analysis, serum miRNA hsa-let-7d-3p was found to be independent predictor of sepsis. Receiver operating characteristic curve (ROC) analysis showed that the area under ROC curve of serum miRNA hsa-let-7d-3p was 0.696 (95% confidence interval [0.615, 0.778]). Conclusion: miRNA hsa-let-7d-3p was identified as novel biomarkers for the early detection of sepsis.
Antithrombotic Therapy in Patients with Recent Stroke and Atrial Fibrillation
Authors: Saberwal Bunny , Ioannou Adam , Lim Wei Y. , Beirne Anne-Marie , Chow Anthony W. , Tousoulis Dimitris , Ahsan Syed , Papageorgiou Nikolaos 
Published: April 2020

:
Atrial fibrillation (AF) is a common arrhythmia which carries a significant risk of stroke. Secondary
prevention, particularly in the acute phase of stroke with anti-thrombotic therapy, has not been validated. The aim
of this review is to evaluate the available evidence on the use of antithrombotic therapy in patients with recent
stroke who have AF, and suggest a treatment algorithm for the various time points, taking into account both the
bleeding and thrombosis risks posed at each stage.
Antithrombotic Treatment after Atrial Fibrillation Ablation
Authors: Antoniou Christos-Konstantinos , Manolakou Panagiota , Arsenos Petros , Dilaveris Polychronis , Gatzoulis Konstantinos , Tousoulis Dimitrios 
Published: April 2020

:Atrial fibrillation is a major cause of debilitating strokes and anticoagulation is an established and indispensable therapy for reducing their rate. Ablation of the arrhythmia has emerged as a putative means of disrupting its natural course by isolating its triggers and modifying its substrate, dependent on the chosen method. An important dilemma lies in the need for continuation of anticoagulation therapy in those previously receiving it following an, apparently, successful intervention, purportedly preventing arrhythmia recurrence with considerably high rates. Current guidance, given scarcity of high-quality data from randomized trials, focuses on established knowledge and recommends anticoagulation continuation based solely on estimated thromboembolic risk. In the present review, it will be attempted to summarize the pathophysiological rationale for maintaining anticoagulation post-successful ablation, along with the latter’s definition, including the two-fold effects of the procedure per se on thrombogenicity. Available evidence pointing to an overall clinical benefit of anticoagulation withdrawal following careful patient assessment will be discussed, including ongoing randomized trials aiming to offer definitive answers. Finally, the proposed mode of post-ablation anticoagulation will be presented, including the emerging, guideline-endorsed, role of direct oral anticoagulants in the field, altering cost/benefit ratio of anticoagulation and potentially affecting the very decision regarding its discontinuation.
Integrated ANP and TOPSIS Method for Supplier Performance Assessment
Authors: Natalia Christine , Surbakti Ita Primsa , Oktavia Chendrasari Wahyu 
Published: April 2020

A supplier has become one of the main factors that influence a company's supply chain activities. Supplier assessment is vital as suppliers have different performance. This study aims at assessing supplier performance using the integration of ANP and TOPSIS methods. Supplier performance assessment was based on supplier criteria indicators. The weighting criteria used ANP was used to determine the most significant influence criteria of supplier performance. Furthermore, TOPSIS was also employed to obtain supplier preference. Eight criteria and twenty-five sub-criteria were used for the supplier performance assessment. The three highest sub-criteria were specification of quality, the flexibility of order changes, and production capacity. The priority results for suppliers were sorted from the highest to lowest ratio values.
PENGARUH DISIPLIN KERJA, PENGALAMAN KERJA DAN PENDIDIKAN KARYAWAN TERHADAP PROMOSI JABATAN PADA SWALAYAN EMBAH;E MURAH PONOROGO, MADIUN DAN MAGETAN
Authors: Andriani Dwi Ayu 
Published: April 2020

Metode survey dipilih sebagai sumber data primer diperoleh melalui kuesioner. Populasi dalam penelitian ini adalah seluruh karyawan Swalayan Embah’e Murah jl. Raya Sampung, Ds. Sumoroto Kec. Kauman Kab. Ponorogo, jl. Raya Barat Maospati, Madiun dan jl. -Raya Takeran, Magetan. Sampel yang digunakan sebanyak 60 responden. Uji instrumen dengan uji validitas dan uji reliabilitas. Teknik bahwa: (1) Disiplin kerja tidak pengaruh terhadap promosi jabatan dengan t-hitung sebesar 0,200 < t-tabel 2,003 dan tingkat signifikan 0,842. (2) Pengalaman kerja tidak pengaruh terhadap promosi jabatan dengan t-hitung -0,608 < t-tabel 2,003 dan tingkat signifikan 0,546. (3) Pendidikan karyawan tidak berpengaruh terhadap promosi jabatan dengan t-hitung 1,521 < t-tabel 2,003 dan tingkat signifikan 0,134. (4) Disiplin Kerja, PengalamanmKerja dan Pendidikan Karyawan tidak berpengaruh terhadap promosi jabatan dengan nilai f-hitung 0,882 < f-tabel 2,54 dan tingkat signifikan 0,456. (5) Besarnya kemampuan model dalam menerangkan variabel Disiplin kerja, Pengalaman Kerjaidan Pendidikan karyawan terhadap Promosi Jabatan (adjusted ) adalah sebesar 4,5%. Persamaan regresi linear berganda diperoleh Y = 14,357+ 0,019 + (-0,072) + 0,219Kata Kunci : Disiplin Kerja, Pengalaman Kerja, Pendidikan Karyawan dan Promosi
Carcinoma basocelular como debut por exposición al sol.
Authors: Álava Cedeño María Susana , Herrera Álava José Carlos , Montesdeoca Chancay Andrea Lissette , Macías Palma Andrea Jamileth , Quijije Roldán Julexi Tatiana 
Published: April 2020

Introducción: Es reconocida la importancia de la luz solar para la evolución de la vida en la tierra y su papel en el desarrollo humano. Sin embargo, todos los humanos, especialmente las personas cuya piel no está tan pigmentada o cuya ocupación o estilo de vida los expone a cantidades excesivas de luz solar, son potencialmente susceptibles a sus efectos nocivos. Es indiscutible el vínculo entre la exposición crónica al sol de la piel humana y las consecuencias clínicas nocivas como el fotoenvejecimiento y los cánceres de piel, como es el carcinoma basocelular.
Objetivo: Describir el efecto que tiene la exposición prolongada al sol como factor de riesgo para desarrollar Carcinoma Basocelular.
Material y métodos: Estudio descriptivo retrospectivo, presentación de caso clínico de Carcinoma Basocelular por exposición al sol
Resultados: Existieuna asociación entre la exposición excesiva a radiaciones solares por el paciente y la aparición de un carcinoma basocelular en la piel.
Conclusiones: El Carcinoma Basocelular representa la neoplasia cutánea más frecuente, por lo cual se hace imprescindible para lograr el correcto diagnóstico y tratamiento, conocer su comportamiento clínico y evolución de la lesión. El factor de riesgo más importante a considerar es el tiempo de exposición a los rayos solares.
Effect of Active Learning in Form of Scientific Approach with Assistance of Student Worksheets Based Problem Based Learning (PBL) Towards Students Biology Psychomotor Competence in Bacterial Material
Authors: Lufri Lufri , Laili Fitria , Anhar Azwir 
Published: April 2020

In the 2013 curriculum, students are demanded to be active in learning process. To actualize it, teacher should has adequate ability and skills by implementing appropriate learning model in teaching. Purpose of the research was to know effect of Active Learning in form of scientific approach with assistance of student worksheets based Problem Based Learning to wards students' Biology competence in Bacterial material. The research method used a quasi experimental research by using randomized control posted only design. The population was students in grade X MIPA of SMAN 1 Pasaman registered in academic year 2018/2019. Samples were taken by using Purposive Sampling technique. Instrument used was psychomotor competence observation sheet. Data analysis was conducted by using Mann Whitney U test. The finding showed that there is a significant difference between students' biology competence in experimental class and control class, in which students' biology competence in experimental class is higher than in control class. Average score of students' biology competence in experimental class is 3.34 (B+) and in control class is 3.17 (B). So, it can be concluded that Active Learning in form of scientific approach with assistance of student worksheets based Problem Based Learning can improve students Biology competence.
Implementasi E-learning Dengan Model Flipped Classroom Dalam Aktivitas Belajar Siswa Pada Mata Pelajaran Sistem Komputer
Authors: Bariyah Siti Husnul 
Published: April 2020

Penelitian ini bertujuan untuk mengimplementasikan E-Learning dengan model Flipped Classroom dalam aktivitas belajar siswa pada mata pelajaran sistem computer. Dilatar belakangi atas kurangnya aktivitas belajar siswa pada mata pelajaran sistem komputer kelas X Multimedia. Metode yang digunakan dalam penelitian ini adalah Mixed Methods atau metode yang menggabungkan antara kuantitatif dengan kualitatif dengan menggunakan strategi sequential mixed methods. Populasi dalam penelitian ini adalah seluruh siswa kelas X sebanyak 3 Kelas Semester 1 SMK Negeri 9 Garut dengan sampel yang diambil 1 kelas yaitu kelas X MM 1 sebanyak 32 siswa. Teknik pengumpulan data dilakukan dengan tes hasil belajar, dan angket yang diberikan kepada siswa maupun guru. Hasil penelitian dan analisis data diketahui bahwa kemampuan aktivitas belajar siswa pada mata pelajaran sistem komputer dengan materi sistem bilangan menunjukan dengan persentase ketuntasan belajar sebanyak 75%, menunjukan rasa ketertarikan 77%, rasa keingintahuan 78%, rasa senang 58%, rasa keaktifan 65%, rasa perhatian 58%.Kata Kunci : aktivitas belajar siswa, media pembelajaran e-learning, Flipped Classroom.
SUBJECT OF CRIMINALISTICS’ TACTIC: FORMATION HISTORY, CONTENTS AND TRENDS
Authors: Shepitko V. 
Published: April 2020

The history of the emergence of tactical beginnings in the investigation of the criminal for forensic purposes is considered and the further formation of the system of scientific knowledge in countering crime is tracked. A historical excursion to the emergence and development of criminal tactics and its role for other branches of forensic tactics has been undertaken. The formation of criminal tactics is conditioned using psychological knowledge in in the context of crime counteraction. In the genesis

of criminalistics tactics, the data of psychological science are traditionally attributed to its sources.
Attention is paid to changing the subject of forensic tactics in modern conditions and the causes of such changes are determined. The content and structure of forensic tactics are conditioned by the need to provide the tactical means of various subjects (investigator, detective, prosecutor, investigative judge, parties to criminal proceedings, court, etc.). The activity approach to criminalistics tactics is proposed and the necessity of isolation of its branches (advocacy, judicial, investigative, searching) is substantiated. Forensic data should be used not only by the prosecution but also by the defense. Arguments are given regarding the need to develop the scientific provisions of advocacy tactics (defense tactics or tactics of professional defense in criminal cases) and to consider it as a separate branch of forensic tactics. The expediency of separating the responding counter-investigation tactics as a structural part of criminalistics tactics was also emphasized.
The substantive side of criminalistics tactics is considered with the help of its structural elements (tactical techniques, tactical systems, tactical combinations, tactical operations, etc.). Changes in the legal field, the model of criminal proceedings, the “revision” of traditional criminal law institutions and the process have a significant impact on the content of criminalistics tactics.
THE CRIMINALISTIC SITUATION AND ITS EFFECT ON THE FORMATION OF THE CONCEPT OF TACTICAL OPERATIONS
Authors: Shevchyuk V. 
Published: April 2020

The problems of formation of scientific concession of tactical operations and its are investigated.
The problems of formation of the scientific concentration of tactical operations and its interrelation with the forensic situation are investigated. It is substantiated that at the present stage of the development of forensics, the problem of developing a separate forensic theory of tactical operations, taking into account the provisions of the forensic situation, is very relevant and important. It is proved that the investigative (judicial) situation exerts a direct managerial influence on a tactical operation, determines the need for its production, determines the specificity and substantive content, so in the procedure of preparing and deciding to conduct a tactical operation, the assessment of the current situation occupies one of the central places. Tactical operation is considered as a specific tactical means of solving the investigative and judicial situation. It is substantiated that studies of the forensic situation open up new perspectives and opportunities for successful formation of the scientific concept of tactical operations and implementation of its provisions in practical activity. Further researches of these issues will contribute to the enrichment of forensic theory, will provide prerequisites for the emergence of new approaches to the solution of important problems of forensic tactics and techniques aimed at improving the efficiency of criminal proceedings. Today the gradual process of formation of the corresponding scientific concept of tactical operations is traced, its interrelation with the forensic situation, which is transformed into an independent forensic theory. Prospective directions of further scientific developments of the considered problems are offered.
Integrating problem-based learning with schoology in criminal law course
Authors: Rachman Dzul , Pratama Rio Arif , Mahayanti Ni Wayan Surya , Kusuma I Putu Indra 
Published: April 2020

This study indents to investigate students’ perception of problem-solving skill and influence of Schoology on students’ ability to solve problems used in the criminal course in tertiary education. In reality, this course requires many activities involving students to solve various types of cases. This study used the quasi-experimental method at the class of criminal law. The students were from the Faculty of Law taking a 14 week enrolled in the Criminal course in the second semester. The instruments in this study were test and questionnaire. Data were analyzed using descriptive and inferential analysis. The overall, There are significant differences in problem-solving skills between the students who learn the material of solubility and constant solubility product using Problem-solving learning model through Schoology in the learning activities. Furthermore, this learning model can also be applied to overcome the lack of time allocation for face-to-face learning.
HUBUNGAN ANTARA PENDAPATAN NASIONAL DAN INVESTASI DI INDONESIA (Suatu Kajian Ekonomi Makro Dengan Model VAR)
Authors: Kholis Muhammad , Astuti Diah , Febrianti Rini 
Published: April 2020

Some previous studies suggested pros and cons regarding the correlation between investment and economic growth. The study is to determined if investment in Indonesia has a positive influence on the economic growth in Indonesia. This study uses a Vector Auto Regression/ VAR. Variables used in this study include economic growth, investment growth, export growth and import growth. The calculations show that investment growth and export growth has a positive effect on economic growth, whereas import growth has a negative effect on economic growth in Indonesia. These results indicate that the driver of economic growth is investment and exports. Thus, the government must create a climate to increase the role of investment in economic growth.

Beberapa kajian terdahulu menyatakan adanya pro dan kontra mengenai korelasi antara investasi dengan pertumbuhan ekonomi. Hipotesis yang ingin dibuktikan dalam kajian ini adalah investasi di Indonesia memiliki pengaruh yang positif dengan pertumbuhan ekonomi di Indonesia. Penelitian ini menggunakan metode Vector Auto Regression (VAR). Variabel yang digunakan dalam penelitian ini antara lain pertumbuhan ekonomi, pertumbuhan investasi, pertumbuhan ekspor dan pertumbuhan impor. Hasil perhitungan menunjukkan bahwa pertumbuhan investasi dan pertumbuhan ekspor memiliki pengaruh positif terhadap pertumbuhan ekonomi, sebaliknya pertumbuhan impor memiliki pengaruh negative terhadap pertumbuhan ekonomi di Indonesia. Hasil ini mengindikasikan bahwa pendorong pertumbuhan ekonomi adalah investasi dan ekspor. Dengan demikian pemerintah harus menciptakan iklim untuk meningkatkan peran investasi dalam pertumbuhan ekonomi.
SIMULASI DAMPAK LIBERALISASI PERDAGANGAN BILATERAL RI-YAMAN TERHADAPPEREKONOMIAN INDONESIA DAN YAMAN: SEBUAH PENDEKATAN SMART MODEL
Authors: Sabaruddin Sulthon Sjahril 
Published: April 2020

This paper is intended to evaluate the impact of Indonesia's trade liberalization with Yemen on the Indonesian economy. In order to evaluate the impact of the Indonesian economy, we analyzed it through the analysis method of Software for Market Analysis and Restrictions on Trade (SMART) model. The result of the analysis, the scenario of the impact of trade liberalization of RI-Yemen on the economy of Indonesia with complete tariff dismantlement, by utilizing the analysis of consumer surplus change, the change of import and export, and the change of tariff income can be concluded that the liberalization of RI-Yaman trade with zero tariff has very positive impact to the economy Indonesia and quite positively to the Yemeni economy. This passage is a form of anticipation of possible policy changes when the political, economic and security situation in Yemen has recovered.

Tulisan ini dimaksudkan untuk mengevaluasi dampak liberalisasi perdagangan Indonesia dengan Yaman terhadap perekonomian Indonesia. Guna mengevaluasi dampak yang ditimbulkan terhadap perekonomian Indonesia, dianalisis melalui pendekatan metode analisis model Software for Market Analysis and Restrictions on Trade (SMART). Hasil analisis skenario dampak liberalisasi perdagangan RI-Yaman terhadap perekonomian Indonesia dengan complete tariff dismantlement, dengan memanfaatkan analisa perubahan consumer surplus, perubahan impor dan ekspor, serta perubahan pendapatan tarif dapat disimpulkan bahwa liberalisasi perdagangan RI-Yaman dengan nol tarif berdampak sangat positif terhadap perekonomian Indonesia dan cukup positif terhadap perekonomian Yaman. Telahaan ini merupakan bentuk antisipasi kemungkinan perubahan kebijakan manakala situasi politik, ekonomi, dan keamanan di Yaman telah pulih kembali.