bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-specific predictive values of biomarkers for immunotherapy efficacy in lung adenocarcinoma
Authors: Jia Mingming , Chi Tian 
Published: October 2020

AbstractIt remains a challenge to accurately predict patient responses to tumor immunotherapy, although various biomarkers have been proposed to predict patient responses to anti-PD-1 therapy. Here by integrating genomic, transcriptomic, proteomic and clinical phenotype data from three immunotherapeutic cohorts and a multiple-dimensional dataset of The Cancer Genome Atlas (TCGA) project, we uncovered a profound effect of Sex on the predictive values of conventional biomarkers in lung adenocarcinoma (LUAD): only in females were nonsynonymous mutation burden (TMB), neoantigen burden, smoking signature, KRAS mutations (especially G12C and G12V) or tumor microenvironment robustly correlated with anti-PD-1 efficacy; the correlations in males were either absent or weaker. We propose that Sex be considered in conjunction with conventional biomarkers when predicting immunotherapy efficacy, and conversely, conventional biomarkers be carefully controlled for when attempting to dissect the impact of Sex on immunotherapy efficacy.
DNA-loop extruding SMC complexes can traverse one anotherin vivo
Authors: Brandão Hugo B. , Ren Zhongqing , Karaboja Xheni , Mirny Leonid A. , Wang Xindan 
Published: October 2020

SummaryThe spatial organization of chromosomes by structural maintenance of chromosomes (SMC) complexes is vital to organisms from bacteria to humans1,2. SMC complexes were recently found to be motors that extrude DNA loops3–11. It remains unclear, however, what happens when multiple SMC complexes encounter one anotherin vivoon the same DNA, how encounters are resolved, or how interactions help organize an active genome12. Here, we set up a “crash-course track” system to study what happens when SMC complexes encounter one another. Using theparS/ParB system, which loads SMC complexes in a targeted manner13–17, we engineered theBacillus subtilischromosome to have multiple SMC loading sites. Chromosome conformation capture (Hi-C) analyses of over 20 engineered strains show an amazing variety of never-before-seen chromosome folding patterns. Polymer simulations indicate these patterns require SMC complexes to traverse past each otherin vivo, contrary to the common assumption that SMC complexes mutually block each other’s extrusion activity18. Our quantitative model of bypassing predicted that increasing the numbers of SMCs on the chromosome could overwhelm the bypassing mechanism, create SMC traffic jams, and lead to major chromosome reorganization. We validated these predictions experimentally. We posit that SMC complexes traversing one another is part of a larger phenomenon of bypassing large steric barriers which enables these loop extruders to spatially organize a functional and busy genome.
Co-infection in critically ill patients with COVID-19: An observational cohort study from England
Authors: Baskaran Vadsala , Lawrence Hannah , Lansbury Louise , Webb Karmel , Safavi Shahideh , Zainuddin Izzah , Huq Tausif , Eggleston Charlotte , Ellis Jayne , Thakker Clare , Charles Bethan , Boyd Sara , Williams Tom , Phillips Claire , Redmore Ethan , Platt Sarah , Hamilton Eve , Barr Andrew , Venyo Lucy , Wilson Peter , Bewick Tom , Daniel Priya , Dark Paul , Jeans Adam R , McCanny Jamie , Edgeworth Jonathan D , Llewelyn Martin J , Schmid Matthias L , McKeever Tricia M , Beed Martin , Lim Wei Shen 
Published: October 2020

AbstractObjectiveTo describe the incidence and nature of co-infection in critically ill adults with COVID-19 infection in England.MethodsA retrospective cohort study of adults with COVID-19 admitted to seven intensive care units (ICUs) in England up to 18 May 2020, was performed. Patients with completed ICU stays were included. The proportion and type of organisms were determined at <48 and >48 hours following hospital admission, corresponding to community and hospital-acquired co-infections.ResultsOf 254 patients studied (median age 59 years (IQR 49-69); 64.6% male), 139 clinically significant organisms were identified from 83(32.7%) patients. Bacterial co-infections were identified within 48 hours of admission in 14(5.5%) patients; the commonest pathogens were Staphylococcus aureus (four patients) and Streptococcus pneumoniae (two patients). The proportion of pathogens detected increased with duration of ICU stay, consisting largely of Gram-negative bacteria, particularly Klebsiella pneumoniae and Escherichia coli. The co-infection rate >48 hours after admission was 27/1000 person-days (95% CI 21.3-34.1). Patients with co-infections were more likely to die in ICU (crude OR 1.78,95% CI 1.03-3.08, p=0.04) compared to those without co-infections.ConclusionWe found limited evidence for community-acquired bacterial co-infection in hospitalised adults with COVID-19, but a high rate of Gram-negative infection acquired during ICU stay.
Decline in mortality among hospitalised covid-19 patients in Sweden: a nationwide observational study
Authors: Strålin Kristoffer , Wahlström Erik , Walther Sten , Bennet-Bark Anna M , Heurgren Mona , Lindén Thomas , Holm Johanna , Hanberger Håkan 
Published: October 2020

ABSTRACTOBJECTIVEIt is important to know if mortality among hospitalised covid-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics of mortality among patients hospitalised for covid-19 in a nationwide study.DESIGNNationwide observational cohort study of all patients hospitalised in Sweden 1 March to 30 June 2020 with SARS-CoV-2 RNA positivity 14 days before to 5 days after admission, and a discharge code for covid-19.SETTINGAll hospitals in Sweden.PARTICIPANTS15 761 hospitalised patients with covid-19, with data compiled by the Swedish National Board of Health and Welfare.MAIN OUTCOME MEASURESOutcome was 60-day all-cause mortality. Patients were stratified according to month of hospital admission. Poisson regression was used to estimate the relative risk of death by month of admission, adjusting for pre-existing conditions, age, sex, care dependency, and severity of illness (Simplified Acute Physiology, version 3), for patients in intensive care units (ICU).RESULTSThe overall 60-day mortality was 17.8% (95% confidence interval (CI), 17.2% to 18.4%), and it decreased from 24.7% (95% CI, 23.0% to 26.5%) in March to 13.3% (95% CI, 12.1% to 14.7%) in June. Adjusted relative risk (RR) of death was 0.56 (95% CI, 0.51 to 0.63) for June, using March as reference. Corresponding RR for patients not admitted to ICU and those admitted to ICU were 0.60 (95% CI, 0.53 to 0.67) and 0.61 (95% CI, 0.48 to 0.79), respectively. The proportion of patients admitted to ICU decreased from 19.5% (95% CI, 17.9% to 21.0%) in the March cohort to 11.0% (95% CI, 9.9% to 12.2%) in the June cohort.CONCLUSIONSThere was a gradual decline in mortality from March to June 2020 in Swedish hospitalised covid-19 patients, which was independent of pre-existing conditions, age, and sex. Future research is needed to explain the reasons for this decline. The changing covid-19 mortality should be taken into account when management and results of studies from the first pandemic wave are evaluated.
The effect of China factor on Taiwan's elections: how has it changed across generations from 2008 to 2014?
Authors: Weng Dennis Lu-Chung , Chen Lu-Huei , Wang Ching-Hsing 
Published: October 2020

PurposeThe main purpose of this study is to reveal how the China factor influences Taiwan voters' evaluations of the two major parties across elections and generations. We contend that 1) elderly Taiwan voters may take the China factor more seriously than younger cohorts, and 2) China factor may be weighted differently depending on the levels of elections. More importantly, we argue that the China factor is tangled with voters' partisanship.Design/methodology/approachData gathered from 2008 to 2014 Taiwan's Election and Democratization Study (TEDS) enable in investigating the influence of the China factor on Taiwan people's vote choices in the two local and two presidential elections. To answer the research question, this study applies issue voting theory and the seemingly unrelated regression (SUR) employed for empirical investigations.FindingsThe findings of this study provide empirical evidence on how political generations have changed their reactions to China in Taiwan's elections. The fundamental variables, party identification and the China issue are still very important and cannot be disregarded. Specifically, the China factor played a quite influential role in the Democratic Progressive Party (DPP) supporters' voting decisions regardless of their generations, whereas its effect on the Kuomintang (KMT) supporters' voting decisions varies depending on electoral contexts and generations.Originality/valueWhile some scholars might suspect that the single item is not sufficient to be an effective predictor of vote choice, we contend that the China factor is definitely the most significant component in Taiwan's elections, especially when it is tangled with partisanship. The SUR approach in this study confirms that partisanship and the China factor cannot be viewed separately.
Implementation of age-friendly initiatives in smart cities: probing the barriers through a systematic review
Authors: Torku Alex , Chan Albert P.C. , Yung Esther H.K. 
Published: October 2020

PurposeThe purpose of this study is to identify the barriers that hinder the implementation of age-friendly initiatives in smart cities.Design/methodology/approachA systematic review of the literature was conducted using Scopus search engine. Relevant keywords were used to discover 81 publications in academic journals. The titles, abstracts, keywords and full texts of the publications were examined to select 39 publications that were relevant for identifying the barriers that hinder the implementation of age-friendly initiatives in smart cities. The contents of the 39 relevant publications were analysed to ascertain the key barriers. A system thinking approach was adopted to understand the interaction among the barriers.FindingsThe study identified five key groups of barriers – namely physical barriers and environmental characteristics, technological barriers, social barriers, financial barriers and political barriers – that smart cities encountered or are likely to encounter in implementing age-friendly initiatives. Moreover, practical examples of good age-friendly implementation practices were highlighted.Research limitations/implicationsA limitation of this study is in the number of publications reviewed. Despite the comprehensive review, the number of publications reviewed may not be exhaustive. This is justified by the inapplicability of considering all possible keywords in one review study.Practical implicationsThe systemic perspective of the barriers that hinder the implementation of age-friendly initiatives in smart cities would support policymakers in formulating policy recommendations to improve age-friendliness in cities.Originality/valueThis study underscores the variable and dynamic nature of developing age-friendly smart cities and forms novel basis for gaining insights into the multiple factors that can promote the integration of age-friendly initiatives within smart cities.
Same talk, different reaction? Communication, emergent leadership and gender
Authors: Schlamp Sofia , Gerpott Fabiola H. , Voelpel Sven C. 
Published: October 2020

PurposeWe investigate the role of gender in linking communicative acts that occur in the interactions of self-managed teams to emergent leadership. Specifically, this study presents a framework that differentiates between agentic and communal task- and relations-oriented communication as predictors of emergent leadership, and it hypothesizes that men and women do not differ in what they say but do differ in how they are rewarded (i.e. ascribed informal leadership responsibilities) for their statements.Design/methodology/approachInteraction coding was used to capture the meeting communication of 116 members of 41 self-managed teams.FindingsMen and women exhibited the same amount of agentic and communal task- and relations-oriented communication and were equally likely to emerge as leaders. However, men experienced an emergent leadership advantage when engaging in agentic and communal task-oriented behaviors. Agentic and communal relations-oriented behaviors did not predict emergent leadership.Research limitations/implicationsThe findings imply that theories could be more precise in differentiating between objective behaviors (i.e. actor perspective) and perceptions thereof (i.e. observer perspective) to understand why women experience a disadvantage in assuming leadership roles.Practical implicationsAlthough women displayed the same verbal behaviors as men, they experienced different consequences. Organizations can provide unconscious bias training programs, which help increase employees' self-awareness of a potential positive assessment bias toward men's communication.Originality/valueThis research utilizes an innovative, fine-grained coding approach to gather data that add to previous studies showing that, unlike men, women experience a disadvantage in terms of emergent leadership ascriptions when they deviate from stereotypically expected behavior.
Customer brand engagement during service lockdown
Authors: Hollebeek Linda D. , Smith Dale L.G. , Kasabov Edward , Hammedi Wafa , Warlow Alexander , Clark Moira K. 
Published: October 2020

Purpose
While the customer brand engagement (CBE) research has advanced important insight, most studies to date explore CBE under regular, free-market conditions, yielding an important knowledge gap regarding its manifestation under less regular conditions, including disaster/pandemics. This study, therefore, aims to explore CBE with essential/non-essential service during COVID-19-prompted citizen lockdown.

Design/methodology/approach
Based on a review, the authors develop a framework of lockdown-based CBE with essential/non-essential service interactions, which are conceptualized by their respective capacity to meet differing needs in Maslow’s hierarchy. The authors view lockdown-based essential/non-essential service interactions to differentially impact CBE, as summarized in a set of propositions.

Findings
The framework depicts lockdown-based essential/non-essential service interactions and their respective impact on CBE. The authors propose two essential service modes (i.e. socially distant/platform-mediated interactions) and two non-essential service modes (i.e. service closure/platform-mediated interactions), which the authors hypothesize to differently affect CBE. Moreover, the authors view the associations between our lockdown-based service modes and CBE to be moderated by customers’ regulatory focus (i.e. promotion/prevention), as formalized in the propositions.

Research limitations/implications
Given the authors’ focus on lockdown-based CBE, this paper adds unique insight to the literature. It also raises ample opportunities for further study, as outlined.

Practical implications
This study yields important managerial implications, including the suggested adoption of differing tactics/strategies to leverage promotion/prevention-focused customers’ brand engagement during lockdown.

Originality/value
By exploring the effects of lockdown-based essential/non-essential service modes on promotion/prevention-focused customers’ brand engagement, this paper adds novel insight.
Conflict management as an organizational capacity: survey of hospital managers in healthcare organizations
Authors: Vesperi Walter , Ventura Marzia , Cristofaro Concetta Lucia 
Published: October 2020

Purpose
The purpose of this paper is twofold. The first objective is to outline the main theoretical framework on the conflict style phenomenon; the second purpose is to understand the conflict style in a sample of Medical Health Manager.

Design/methodology/approach
The authors based this research on qualitative-quantitative analysis. This study starts with a survey questionnaire as a method to collect quantitative data. Therefore, the authors conducted a survey on the style of conflict management of hospital managers with subordinates. A modified version of the Rahim Organizational Conflict Inventory II (ROCI II) (Rahim, 1983) – Module B is used. This instrument is composed of 28 entries.

Findings
The results of this study offer a double perspective. From a theoretical point of view, the results highlight the main theoretical references related to conflict management. In particular, the main currents of study and the results of empirical evidence have been identified within organizational theory. The empirical part of this study, instead, offers a survey, carried out through the administration of the ROCI II – module B questionnaire.

Originality/value
This paper offers interesting food for thought on conflict management. In particular, it offers theoretical references on the subject and on the validation of the ROCI II - Form B model, in health organizations.
Teaching young adult learners is an intelligent orchestration of science and arts
Authors: Namhata Rima , Ghosh Vinit 
Published: October 2020

Purpose
This paper aims to propose a classroom teaching orchestration technique, analogically drawing a reference from the movie, Prestige (2006). The generation of post-millennials has shorter attention span and motivation and prefers a learner-centric teaching style. This paper attempts to mitigate such challenges by bringing an analogy with a magic trick along with proposing a “divergent-convergent diamond structure” to anchor and synthesise teaching deliverables for the learners.

Design/methodology/approach
This is a practitioner’s study where practical experiences of the authors have led to the conceptualisation of the central theme discussed.

Findings
From a practitioner’s opinion and interpretation, the proposed “divergent-convergent diamond structure” has the potential to make postgraduate classes more engaging. The proposed structure may suggestively promote self-efficacy, trigger curious minds, bring relevance, indulge participatory learning and consolidate the concepts.
Affiliation bias in the online market for rental accommodation
Authors: Bliss Barbara A. , Engelberg Joseph , Warachka Mitch 
Published: October 2020

AbstractWe find evidence of taste‐based discrimination against rival affiliations in the online market for rental accommodation. Airbnb hosts in college towns increase their listing prices more than hotels on home football games against rival teams. By setting listing prices too high as a result of their affiliation bias against rival fans, hosts experience a 30% reduction in rental income. The overestimation of demand, the cost (inconvenience) of temporary relocation, and the likelihood of incurring damage cannot explain the inverse relation between listing price increases, and rental incomes that is limited to games against rival teams. Instead, greater financial constraints are associated with smaller listing price increases, and higher rental incomes on rival games, suggesting that taste‐based discrimination is a luxury.
Vaspin deficiency failed to promote the proliferation of BMSCs in osteoarthritis
Authors: Wang Junfeng , Chen Zhongqiang , Guan Zhenpeng 
Published: October 2020

AbstractObjectiveThe aim of this study was to estimate the possible role of vaspin in the proliferation of bone mesenchymal stem cells (BMSCs) and its molecular mechanisms in the bone marrow microenvironment of osteoarthritis (OA).MethodsThis study included 15 non‐obese elderly patients with severe knee OA and 15 non‐obese controls with femoral neck fracture. Patients all underwent hip or knee arthroplasty surgery to restore joint shape and function. Bone marrow samples were taken during surgery to estimate vaspin and transforming growth factor (TGF)‐β1 levels by enzyme‐linked immunosorbent assay and to observe the effect of vaspin on BMSCs proliferation by Cell Counting Kit‐8. Real‐time polymerase chain reaction and western blot were performed to evaluate the effect of vaspin on the genes and proteins of Akt involved in the PI3K/AKT signaling pathway.ResultsBone marrow vaspin levels were significantly lower in OA patients compared to controls (P = .03). Furthermore, we found a significant correlation between vaspin and TGF‐β1 concentrations in bone marrow (r = .60, P < .01). In addition, the in vitro studies indicated the proliferation of BMSCs was significantly promoted when the vaspin treatment concentration was 150 ng/mL (P < .01). Meanwhile, we found that the Akt messenger RNA and pAkt protein levels in BMSCs were increased after vaspin treatment (P < .05).ConclusionThe findings of this study suggest there was abnormal expression of vaspin in OA bone marrow microenvironment, and vaspin likely had a mediator role in the proliferation of BMSCs, which may work by promoting the activation of the PI3K/AKT signaling pathway.
Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits
Authors: Sweet‐Jones J. , Yurchenko A. A. , Igoshin A. V. , Yudin N. S. , Swain M. T. , Larkin D. M. 
Published: October 2020

SummaryRussian sheep breeds represent an important economic asset by providing meat and wool, whilst being adapted to extreme climates. By resequencing two Russian breeds from Siberia: Tuva (n = 20) and Baikal (n = 20); and comparing them with a European (UK) sheep outgroup (n = 14), 41 million variants were called, and signatures of selection were identified. High‐frequency missense mutations on top of selection peaks were found in genes related to immunity (LOC101109746) in the Baikal breed and wool traits (IDUA), cell differentiation (GLIS1) and fat deposition (AADACL3) in the Tuva breed. In addition, genes found under selection owing to haplotype frequency changes were related to wool traits (DSC2), parasite resistance (CLCA1), insulin receptor pathway (SOCS6) and DNA repair (DDB2) in the Baikal breed, and vision (GPR179) in the Tuva breed. Our results present candidate genes and SNPs for future selection programmes, which are necessary to maintain and increase socioeconomic gain from Siberian breeds.
Spaces for Feminist Commoning? Creative Social Enterprise’s Enclosures and Possibilities
Authors: McLean Heather 
Published: October 2020

AbstractThis paper contributes an intersectional feminist analysis and methodological approach to debates about commoning and social enterprise. Through a narrative description of feminist social enterprise projects based on action research with the Kinning Park Complex, a social centre with a radical history in Glasgow’s South Side, I demonstrate how contemporary community economic development models can entrench intersectional exclusion. Specifically, I show how market‐oriented social enterprise models reproduce precarious work, hinder cooperative ethics, and promote depoliticised notions of difference. However, I also investigate the ways that community organisers and activists at KPC are re‐working these neoliberal models to carve out spaces for feminist commoning. Through these acts, women‐identifying and non‐binary activists, artists, and community organisers grapple with the classed, raced, and gendered politics of community organising and foster solidarities across difference.