bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wholesale and retail trade sector occupational fatal and nonfatal injuries and illnesses from 2006 to 2016: Implications for intervention
Authors: Putz Anderson Vern , Schulte Paul A. , Novakovich Jeanette , Pfirman Donna , Bhattacharya Anasua 
Published: November 2019

AbstractBackgroundWe analyzed the Bureau of Labor Statistics (BLS) fatal and nonfatal injuries and illness data on U.S. workers in the wholesale and retail trade (WRT) sector from 2006 to 2016. The purpose was to identify elevated fatal and nonfatal injury and illness rates in WRT subsectors.MethodsTo assess the WRT health and economic burden, we retrieved multiple BLS data sets for fatal and nonfatal injury and illness data, affecting more than 20 million employees. We examined yearly changes in incidence rates for lost work‐time across event and exposure categories.ResultsIn 2016, 553 100 injuries and illnesses and 461 fatalities occurred among WRT workers. WRT has a disproportionately 5% larger burden of nonfatal injuries for its size. From 2006 through 2016, wholesale sector fatality rates (4.9/100 000 FTE) exceeded private industry rates (3.8/100 000 FTE). The largest causal fatal factors were transportation in wholesale and violence in retail. Private industry and WRT experienced a decline in nonfatal injuries and illnesses. Wholesale subsectors with elevated nonfatal rates included durable and nondurable goods, recycling, motor parts, lumber, metal and mineral, grocery, and alcohol merchants. Retail subsectors with elevated rates included motor parts dealers, gasoline stations, nonstores, tire dealers, home and garden centers, supermarkets, meat markets, warehouse clubs, pet stores, and fuel dealers.DiscussionThrough the identification of safety and health risks, researchers and safety practitioners will be able to develop interventions and focus future efforts in advancing the safety and health of WRT employees.
Highly Acidic Conjugate‐Base‐Stabilized Carboxylic Acids Catalyze Enantioselective oxa‐Pictet–Spengler Reactions with Ketals
Authors: Zhu Zhengbo , Odagi Minami , Zhao Chenfei , Abboud Khalil A. , Kirm Helmi Ulrika , Saame Jaan , Lõkov Märt , Leito Ivo , Seidel Daniel 
Published: November 2019

AbstractAcyclic ketone‐derived oxocarbenium ions are involved as intermediates in numerous reactions that provide valuable products, however, they have thus far eluded efforts aimed at asymmetric catalysis. We report that a readily accessible chiral carboxylic acid catalyst exerts control over asymmetric cyclizations of acyclic ketone‐derived trisubstituted oxocarbenium ions, thereby providing access to highly enantioenriched dihydropyran products containing a tetrasubstituted stereogenic center. The high acidity of the carboxylic acid catalyst, which exceeds that of the well‐known chiral phosphoric acid catalyst TRIP, is largely derived from stabilization of the carboxylate conjugate base through intramolecular anion‐binding to a thiourea site.
Controlling the Microstructure of Conjugated Polymers in High‐Mobility Monolayer Transistors via the Dissolution Temperature
Authors: Li Mengmeng , Bin Haijun , Jiao Xuechen , Wienk Martijn M. , Yan He , Janssen René A. J. 
Published: November 2019

AbstractIt remains a challenge to precisely tailor the morphology of polymer monolayers to control charge transport. Herein, the effect of the dissolution temperature (Tdis) is investigated as a powerful strategy for morphology control. Low Tdis values cause extended polymer aggregation in solution and induce larger nanofibrils in a monolayer network with more pronounced π–π stacking. The field‐effect mobility of the corresponding monolayer transistors is significantly enhanced by a factor of four compared to devices obtained from high Tdis with a value approaching 1 cm2 V−1 s−1. Besides that, the solution kinetics reveal a higher growth rate of aggregates at low Tdis, and filtration experiments further confirm that the dependence of the fibril width in monolayers on Tdis is consistent with the aggregate size in solution. The generalizability of the Tdis effect on polymer aggregation is demonstrated using three other conjugated polymer systems. These results open new avenues for the precise control of polymer aggregation for high‐mobility monolayer transistors.
Zeise, Liebig, Jensen, Hückel, Dewar, and the Olefin π‐Complex Bonds
Authors: Wentrup Curt 
Published: November 2019

AbstractZeise's salt, KPt(C2H4)Cl3, was the first characterized organometallic compound; it was also the first olefin π‐complex. It was published in 1825–1830 in the middle of a fight between Dumas on the one hand and Berzelius and Liebig on the other, who defended the etherin (ethylene) and radical theories, respectively. Although Zeise's formulation as a compound containing ethylene was vindicated, the fight went on for many years. This was a time when the theories of organic chemistry were being developed, before any clear understanding of the nature of molecules, bonding, and structure. Zeise thought of the structure of his salt as a product of the addition of PtCl2 to ethylene. Jensen assumed a central bonding to ethylene but needed theoretical assistance to explain it. His attempt to obtain such an explanation from Hückel failed, and it was Dewar who explained the nature of π‐complexes in molecular orbital terms in 1951.
Green synthesis and formulation a modern chemotherapeutic drug of Spinacia oleracea L. leaf aqueous extract conjugated silver nanoparticles; Chemical characterization and analysis of their cytotoxicity, antioxidant, and anti‐acute myeloid leukemia properties in comparison to doxorubicin in a leukemic mouse model
Authors: Zangeneh Mohammad Mahdi 
Published: November 2019

There is an increasing commercial demand for nanoparticles due to their wide applicability in various areas such as electronics, catalysis, chemistry, energy, and medicine. Recently, researchers have tried to synthesize the chemotherapeutic drugs from metallic nanoparticles especially gold and silver nanoparticles. In the current study, silver nanoparticles using Spinacia oleracea L. leaf aqueous extract (AgNPs) are reported for the first time to exert a dietary remedial property compared to doxorubicin in an animal model of acute myeloid leukemia. The synthesized AgNPs were characterized using different techniques including UV‐Vis., EDS, TEM, FT‐IR, and FE‐SEM. UV‐Vis. indicates an absorption band at 462 nm that is related to the surface plasmon resonance of AgNPs. In EDS, metallic silver nanocrystals indicated an optical absorption peak at roughly 4keV. TEM and FE‐SEM images exhibited a uniform spherical morphology and diameters of 20–40 nm for the nanoparticles. FT‐IR findings suggested antioxidant compounds in the nanoparticles were the sources of reducing power, reducing silver ions to AgNPs. In vivo design, induction of acute myeloid leukemia was done by 7,12‐Dimethylbenz[a]anthracene in 75 mice. Then, the animals were randomly divided into six subgroups, including control, untreated, AgNO3, S. oleracea, AgNPs, and doxorubicin. Similar to doxorubicin, AgNPs significantly (p ≤ 0.01) reduced the pro‐inflammatory cytokines, and the total WBC, blast, neutrophil, monocyte, eosinophil, and basophil counts and increased the weight of the body, the anti‐inflammatory cytokines and the lymphocyte, platelet, and RBC parameters as compared to the untreated mice. DPPH free radical scavenging test was done to evaluate the antioxidant potentials of AgNO3, S. oleracea, AgNPs, and doxorubicin. DPPH test revealed similar antioxidant potentials for doxorubicin and AgNPs. For the analyzing of cytotoxicity effects of AgNO3, S. oleracea, AgNPs, and doxorubicin, MTT assay was used on HUVEC, Human HL‐60/vcr, 32D‐FLT3‐ITD, and Murine C1498 cell lines. AgNPs similar to doxorubicin had low cell viability dose‐dependently against Human HL‐60/vcr, 32D‐FLT3‐ITD, and Murine C1498 cell lines without any cytotoxicity on HUVEC cell line. These results reveal that the inclusion of S. oleracea leaf aqueous extract improves the remedial effects of AgNPs, which led to a significant enhancement in the antioxidant, cytotoxicity, and anti‐acute myeloid leukemia potentials of the nanoparticles. It seems that AgNPs can be applied as a chemotherapeutic supplement or drug for the treatment of acute myeloid leukemia in the clinical trial.
Modeling the valorization of poultry litter via thermochemical processing
Authors: Adeniyi Adewale G. , Ighalo Joshua O. , Onifade Damilola V. , Adeoye Samson A. 
Published: November 2019

AbstractWaste management via thermochemical processing is gaining increasing importance as larger volumes of solid waste are generated yearly. The poultry industry generates a variety of wastes, of which the largest stream in terms of volume is the litter. In this study, three thermodynamic models were developed on ASPEN Plus v8.8 for pyrolysis, in‐line steam reforming, and gasification of poultry litter. At optimal pyrolysis of 450 °C, the product yield was 43.74 wt% bio‐oil, 6.71 wt% gas, and 49.55 wt% char. The optimal conditions for the in‐line steam reforming of poultry litter were observed to be 400 °C temperature and 12 kg kg−1 steam‐to‐feed ratio (STFR), yielding a syngas composition of 70.2 mol% H2, 29.4 mol% CO2, 0.22 mol% CH4, and a trace amount of CO. The optimal conditions for the gasification of poultry litter were 700 °C temperature and 0.2 kg kg−1, yielding a syngas composition of 52.6 mol% H2, 10.3 mol% CO2, 2.77 mol% CH4 and 34.3 mol% CO. Gasification gave a higher syngas yield but with less quality. Steam reforming gave better quality but a lower yield. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd
Energy eco‐innovations for sustainable development: Exploring organizational strategic capabilities through an energy cultures framework
Authors: Walton Sara , Zhang Annie , O'Kane Conor 
Published: November 2019

AbstractThis article reports on research on energy eco‐innovation using case studies of firms. Positioning energy efficiency changes in an organization as “eco‐innovations,” the paper examines the firm‐level resources involved for these to be successful. To identify these resources, the energy cultures (EC) framework, an organizing tool to understand energy behaviour, is drawn on. From an analysis of 142 case studies of successful business and energy change, three models are developed. It is found that the EC framework (consisting of norms, material culture, and practices) makes explicit key resources involved in developing energy eco‐innovations. The findings show that for an eco‐innovation capability, there is a need to align the physical resources with intangible resources to lead to learning and knowledge that, in turn, needs to be aligned with the firm strategies. This research has implications for developing company strategy and practice to drive energy eco‐innovations.
Effect of green innovation strategy on firm‐idiosyncratic risk: A competitive action perspective
Authors: Lin Woon Leong , Mohamed Azali Bin , Sambasivan Murali , Yip Nick 
Published: November 2019

AbstractDespite increasing concern for corporate environmental responsibility in numerous industries, the relationship between green innovation strategy (GIS) and idiosyncratic risk is a rarely scrutinised topic, particularly in the automotive domain. In this study, we empirically explore the association between GIS and idiosyncratic risk and analyse the moderating role played by the firm's competitive action. We rely on the secondary information sourced for 132 top automotive firms, in the period ranging from 2011 to 2017 by applying the system generalised methods of moments estimator to the dynamic panel data model. Our findings indicate that GIS significantly reduces the idiosyncratic risk of all firms, and this relationship strengthens with the increase in the competitive action of the firms. Our evidence supports “it pays to be green” firm heterogeneity argument. This study highlights the academic and managerial implications and focuses on the environmental issues published in environmental management literature.
Influence of potato pulp on gluten network structure in wheat dough and steamed bread
Authors: Cao Yanfei , Yang Zhe , Zhang Haijing , Guo Peng , Dong Shuang , Li Hongjun 
Published: November 2019

AbstractBackground and objectivesSteamed bread is the traditional fermented wheat product in China and has popularity in other Asian, European, and some North American countries. Wheat flour replaced by potato pulp can be an effective way to improve nutritive values of steamed bread and promote potato consumption. The aim of this study was to investigate the influences of potato pulp on disulfide bond (S–S) contents, protein secondary structures, starch crystallinity, and microstructures of dough and steamed bread. Spectrophotometry, Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM) were used for analyses.FindingsThe dough and steamed bread samples added with 10% potato pulp had higher S–S contents than the other tested samples. Compared with the control, the free sulfhydryl contents in the dough (3.2 μmol/g) and steamed bread (2.7 μmol/g) added with 30% potato pulp significantly increased, whereas those of the S–S decreased to 10.0 and 10.9 μmol/g, respectively. The contents of β‐sheet and α‐helix in the dough and steamed bread containing 10% potato pulp were higher than those in samples without the potato pulp. The relative crystallinity of starch in the dough significantly decreased with increasing potato pulp level (p < .05). The CLSM and SEM images showed that potato pulp significantly affected the microstructure. Sample with 10% potato pulp possessed improved gluten network structures. However, samples with high potato pulp contents (>20%) possessed more gas cells and a loose gluten network structure.ConclusionsThe results showed that the addition of potato pulp affected gluten network structural characteristics in wheat flour dough and steamed bread, but appropriate level of potato pulp could be produced for gluten network enhancement.Significance and noveltyThe study would contribute to better understanding of the effect of potato pulp on the structural characterization of gluten network in steamed bread making and provide theoretical basis for in‐depth application to wheat‐based products.
Neurosarcoidosis manifesting as panhypopituitarism
Authors: Oye Monique , Chahin Michael , Krishnan Nithya , Reddy Pramod 
Published: November 2019

AbstractPanhypopituitarism secondary to Neurosarcoidosis is a rare however serious complication. This diagnosis should remain in the differential in patients with hypothalamic‐pituitary dysfunction. Biopsy of lesions will give definitive diagnosis.
Pervaporation Reactor for Enhanced Esterification of Lactic Acid and Isobutyl Alcohol
Authors: Chandane Vishal S. , Rathod Ajit P. , Wasewar Kailas L. 
Published: November 2019

AbstractThe esterification of lactic acid and isobutyl alcohol to isobutyl lactate and water was intensified. An ex situ pervaporation reactor (PVR) shifted the equilibrium towards the formation of isobutyl lactate. The effects of temperature, molar acid/alcohol ratio, catalyst loading, and ratio of effective membrane area to total reaction volume were investigated with and without a PVR. Lactic acid conversion beyond reaction equilibrium was enhanced with such a reactor. The partial fluxes of the individual components were evaluated for each reaction parameter indicating that the membrane was selective towards separation of water and exhibited a good performance. The performance of the ex situ PVR was studied, which revealed that the water removal rate exceeded the water production rate.
QSAR and docking studies on Triazole Benzene Sulfonamides with human Carbonic anhydrase IX inhibitory activity
Authors: Gopinath P. , Kathiravan M.K. 
Published: November 2019

AbstractCancer is the second leading cause of death worldwide, and breast cancer accounts for 2.09 million cases in the year 2018. Hypoxia‐related human carbonic anhydrase IX enzyme was found to play a key role in metastasis also. In this view, quantitative structure activity relationship (QSAR) studies were carried out by QSARINS on triazole benzene sulfonamide derivatives for carbonic anhydrase IX inhibitory activity targeting breast cancer. A new scope to explore 3D‐MoRSE descriptors in carbonic anhydrase inhibition has been initiated by this study. The best model 3 generated includes five variables MoRSEV22, MoRSEC17, MoRSEV1, MoRSEC4, and MoRSEE2 with statistical values R2 = 0.7852, CCCtr = 0.8797, Q2LOO = 0.7237, Q2LMO = 0.7071, CCCcv = 0.8472, R2ext = 0.7894, and CCCext = 0.8784. The developed QSAR model suggests that the atomic volume, atomic charges, and Sanderson's electronegativity play key roles and were extremely helpful in designing and optimizing the lead. Molecular docking studies were performed using Autodock v 4.2.6 and the residues of active site region involving both hydrophilic and hydrophobic parts interacted with best predicted active compounds 1d, 3e, 6f and 9f. The study leads to the development of new inhibitors targeting breast cancer.
Impact of immune thrombocytopenic purpura on clinical outcomes in patients with acute myocardial infarction
Authors: Chehab Omar , Abdallah Nadine , Kanj Amjad , Pahuja Mohit , Adegbala Oluwole , Morsi Rami Z. , Mishra Tushar , Afonso Luis , Abidov Aiden 
Published: November 2019

AbstractBackgroundPatients with immune thrombocytopenic purpura (ITP) admitted with acute myocardial infarction (AMI) may be challenging to manage given their increased risk of bleeding complications. There is limited evidence in the literature guiding appropriate interventions in this population. The objective of this study is to determine the difference in clinical outcomes in AMI patients with and without ITP.MethodsUsing the United States national inpatient sample database, adults aged ≥18 years, who were hospitalized between 2007 and 2014 for AMI, were identified. Among those, patients with ITP were selected. A propensity‐matched cohort analysis was performed. The primary outcome was in‐hospital mortality. Secondary outcomes were coronary revascularization procedures, bleeding and cardiovascular complications, and length of stay (LOS).ResultsThe propensity‐matched cohort included 851 ITP and 851 non‐ITP hospitalizations for AMI. There was no difference in mortality between ITP and non‐ITP patients with AMI (6% vs7.3%, OR:0.81; 95% CI:0.55‐1.19; P = .3). When compared to non‐ITP patients, ITP patients with AMI underwent fewer revascularization procedures (40.9% vs 45.9%, OR:0.81; 95% CI:0.67‐0.98; P = .03), but had a higher use of bare metal stents (15.4% vs 11.3%, OR:1.43; 95% CI:1.08‐1.90; P = .01), increased risk of bleeding complications (OR:1.80; CI:1.36‐2.38; P < .0001) and increased length of hospital stay (6.14 vs 5.4 days; mean ratio: 1.14; CI:1.05‐1.23; P = .002). More cardiovascular complications were observed in patients requiring transfusions.ConclusionsPatients with ITP admitted for AMI had a similar in‐hospital mortality risk, but a significantly higher risk of bleeding complications and a longer LOS compared to those without ITP. Further studies are needed to assess optimal management strategies of AMI that minimize complications while improving outcomes in this population.
The impact of the Patient Protection and Affordable Care Act on insurance coverage and cancer‐directed treatment in HIV‐infected patients with cancer in the United States
Authors: Corrigan Kelsey L. , Nogueira Leticia , Yabroff K. Robin , Lin Chun Chieh , Han Xuesong , Chino Junzo P. , Coghill Anna E. , Shiels Meredith , Jemal Ahmedin , Suneja Gita 
Published: November 2019

BackgroundTo the authors' knowledge, little is known regarding the impact of the Patient Protection and Affordable Care Act (ACA) on people living with HIV and cancer (PLWHC), who have lower cancer treatment rates and worse cancer outcomes. To investigate this research gap, the authors examined the effects of the ACA on insurance coverage and receipt of cancer treatment among PLWHC in the United States.MethodsHIV‐infected individuals aged 18 to 64 years old with cancer diagnosed between 2011 and 2015 were identified in the National Cancer Data Base. Health insurance coverage and cancer treatment receipt were compared before and after implementation of the ACA in non–Medicaid expansion and Medicaid expansion states using difference‐in‐differences analysis.ResultsOf the 4794 PLWHC analyzed, approximately 49% resided in nonexpansion states and were more often uninsured (16.7% vs 4.2%), nonwhite (65.2% vs 60.2%), and of low income (36.3% vs 26.9%) compared with those in Medicaid expansion states. After 2014, the percentage of uninsured individuals decreased in expansion states (from 4.9% to 3%; P = .01) and nonexpansion states (from 17.6% to 14.6%; P = .06), possibly due to increased Medicaid coverage in expansion states (from 36.9% to 39.2%) and increased private insurance coverage in nonexpansion states (from 29.5% to 34.7%). There was no significant difference in cancer treatment receipt noted between Medicaid expansion and nonexpansion states. However, the percentage of PLWHC treated at academic facilities increased significantly only in expansion states (from 40.2% to 46.7% [P < .0001]; difference‐in‐differences analysis: 7.2 percentage points [P = .02]).ConclusionsThe implementation of the ACA was associated with improved insurance coverage among PLWHC. Lack of insurance still is common in non–Medicaid expansion states. Patients with minority or low socioeconomic status more often resided in nonexpansion states, thereby highlighting the need for further insurance expansion.
A machine learning method correlating pulse pressure wave data with pregnancy
Authors: Chen Jianhong , Huang Huang , Hao Wenrui , Xu Jinchao 
Published: November 2019

AbstractPulse feeling , representing the tactile arterial palpation of the heartbeat, has been widely used in traditional Chinese medicine (TCM) to diagnose various diseases. The quantitative relationship between the pulse wave and health conditions however has not been investigated in modern medicine. In this paper, we explored the correlation between pulse pressure wave (PPW), rather than the pulse key features in TCM, and pregnancy by using deep learning technology. This computational approach shows that the accuracy of pregnancy detection by the PPW is 84% with an area under the curve (AUC) of 91%. Our study is a proof of concept of pulse diagnosis and will also motivate further sophisticated investigations on pulse waves.
Reduction of Transient Histidine Radicals by Tyrosine: Influence of the Protonation State of Reactants
Authors: Morozova Olga B. 
Published: November 2019

AbstractThe role of tyrosine radicals as mediators of electron transfer reactions in enzymes is well established, as is the involvement of histidine as a binding partner. But how environmental factors affect these reactions remains poorly explored. In the study presented here, kinetic data on the influence of the protonation state of the reactants on the reduction of transient histidine radicals by tyrosine were obtained in neutral and basic aqueous solution (pH 6–12) using time‐resolved chemically induced dynamic nuclear polarization (CIDNP). The histidine radicals were generated in the photo‐induced reaction with the photosensitizer 3,3′,4,4′‐tetracarboxy benzophenone. From model simulations of the detected CIDNP kinetics, pH dependent second‐order rate constants of the reduction of histidine radicals were obtained for four possible combinations of the amino acids and their N‐acetyl derivatives, and also for the systems histidine‐phenylalanine dipeptide/N‐acetyl tyrosine, and N‐acetyl histidine/tyrosine‐glutamine dipeptide. The pH dependences of the rate constant of the reduction reaction are explained accounting for the protonation states of reactants, and also protonation state of the equilibrium form of the product ‐ reduced form of histidine radical, which is histidine with neutral or a positively charged imidazole.