bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta‐analysis
Authors: Varela‐Centelles Pablo , Gonzalez‐Moles Miguel Ángel , Seoane‐Romero Javier , Leira‐Feijoo Yago , Takkouche Bahi , Seoane‐Romero Juan Manuel 
Published: September 2020

AbstractObjectivesTo identify the immunohistochemical pattern of non‐tumoral epithelium adjacent to lip cancer (ANTE) to unveil molecular alterations and potential biomarkers in lip cancer patients.Materials and MethodsA systematic search at MEDLINE, EMBASE and proceedings Web of Science, OpenGrey and WorldCat. The PICOS outline (Population: lip cancer patients; Intervention: immunostaining with biomarkers in surgical specimens; Comparisons: ANTE versus LC; Outcomes: primary—to identify the immunohistochemical pattern of peritumoral epithelium and secondary—to assess the immunoreactivity of LC epithelium; and Study design: cross‐sectional, case‐control and cohort studies).ResultsA total of 339 records were identified. Seven studies reporting on ANTE and LCs were included in the qualitative synthesis, and 4 of them (p53 immunostaining) were selected for meta‐analysis. In the ANTE group, the pooled prevalence of p53 was 0.74 (95% CI: 0.66 – 0.82), while in the lip squamous cell carcinoma group this prevalence was 0.83 (95% CI: 0.75 – 0.89).ConclusionsSimilar immunoexpression was found in lip epithelium adjacent to lip carcinoma, even in epithelia with normal appearance or mild histological alterations. The role of biomarkers in the follow‐up of actinic cheilitis patients deserves additional clinical assessment.
Sagitta of ophthalmic lenses
Authors: Faria‐e‐Sousa Sidney Julio 
Published: September 2020

AbstractPurposeTo propose alternative formulas for the sagitta calculation of ophthalmic lenses.MethodsEquation factoring.ResultsThe conventional sagitta formula is algebraically inconsistent when applied to curves with direction‐oriented radii. It is possible to correct this problem by factoring it.ConclusionsThe conventional sagitta formula can and should be replaced by unambiguous equations.
When States Align Social Welfare Programs: Considering the Child Support Income Exclusion for SNAP
Authors: Heflin Colleen M. , Lopoo Leonard M. , Mackenzie‐Liu Mattie 
Published: September 2020

ObjectiveIn the United States, state social services rarely coordinate across departments, a practice that could both increase receipt and reduce administrative burden. The purpose of this article is to investigate the state‐level conditions associated with the adoption of policies that benefit participants in multiple social welfare programs, focusing on the case of the child support income exclusion for SNAP benefit eligibility calculations.MethodsUsing annual data for each of the states (including the District of Columbia), we estimate multiple analyses to test three hypotheses regarding which factors are associated with policy adoption.ResultsWe find that collaboration across social programs is more likely as state income tax revenues increase and when administrative costs are lower.ConclusionsOur findings suggest that state revenue and administrative costs are associated with state interagency alignment but find only weak evidence that political ideology is a factor.
Isavuconazole for the prophylaxis and treatment of invasive fungal disease: A single‐center experience
Authors: Vu Christine A. , Rana Meenakshi M. , Jacobs Samantha E. , Saunders‐Hao Patricia 
Published: September 2020

AbstractBackgroundInvasive fungal disease (IFD) is a serious complication among the immunocompromised population. Isavuconazole is a newer broad‐spectrum antifungal agent with promising efficacy and safety. However, there remains limited data to favor its use over current first‐line agents.ObjectivesWe aimed to evaluate isavuconazole use and describe rates of associated breakthrough invasive fungal disease (bIFD).MethodsA single‐center, retrospective study was conducted to evaluate patients receiving isavuconazole for prophylaxis or treatment of IFD between July 1, 2017 and December 31, 2018. Patient‐related and outcomes data were extracted from electronic medical records. Descriptive statistics were used to analyze our findings.ResultsA total of 54 patients received 61 isavuconazole courses. Isavuconazole was most commonly prescribed for primary prophylaxis in the acute myeloid leukemia (AML) and allogeneic hematopoietic stem cell transplant (HSCT) population along with treatment for possible invasive fungal disease. The primary reasons for choosing isavuconazole included QTc shortening effects, decreased risk of acute kidney injury, broader spectrum of activity, and concern for breakthrough invasive fungal disease on a different prophylactic agent. We found a breakthrough rate of 8.5% for patients and 7.8% for courses.ConclusionsIsavuconazole appears to be a promising alternative for prophylaxis and treatment of invasive fungal disease. We observed similar bIFD rates and improved tolerability when compared to historical data for posaconazole and voriconazole.
Normal Stress Differences of Human Blood in Unidirectional Large-Amplitude Oscillatory Shear Flow
Authors: Saengow Chaimongkol , Giacomin Alan Jeffrey , Dimitrov Andrea Stephanie 
Published: September 2020

AbstractThis work analyzes normal stress difference responses in blood tested in unidirectional large-amplitude oscillatory shear flow (udLAOS), a novel rheological test, designed for human blood. udLAOS mimics the pulsatile flow in veins and arteries, in the sense that it never reverses, and yet also nearly stops once per heartbeat. As for our continuum fluid model, we choose the Oldroyd 8-constant framework for its rich diversity of popular constitutive equations, including the corotational Jeffreys fluid. This work arrives at exact solutions for normal stress differences from the corotational Jeffreys fluid in udLAOS. We discover fractional harmonics comprising the transient part of the normal stress difference responses, and both integer and fractional harmonics, the alternant part. By fractional, we mean that these occur at frequencies other than integer multiples of the superposed oscillation frequency. More generally, predictions from the Oldroyd 8-constant framework are explored by means of the finite difference method. Finally, the generalized versions of both the Oldroyd 8-constant framework and the corotational Jeffreys fluid are employed to predict the nonlinear normal stress responses for the model parameters fitted to udLAOS measurements from three very different donors, all healthy. From our predictions, we are led to expect less variation in normal stress differences in udLAOS from healthy donor to donor, than for the corresponding measured shear stress responses.
Self-administration of adrenaline for anaphylaxis during in-hospital food challenges improves health-related quality of life
Authors: Burrell Sarah , Patel Nandinee , Vazquez-Ortiz Marta , Campbell Dianne E. , DunnGalvin Audrey , Turner Paul J. 
Published: September 2020

ObjectiveTo assess the impact of anaphylaxis on health-related quality of life (HRQL) and self-efficacy in food-allergic patients undergoing in-hospital food challenge.DesignSecondary analysis of a randomised controlled trial.SettingSpecialist allergy centre.PatientsPeanut-allergic young people aged 8–16 years.InterventionsDouble-blind, placebo-controlled food challenge to peanut, with HRQL and self-efficacy assessed using validated questionnaire, approximately 2 weeks prior to and 2 weeks after challenge. Where possible, anaphylaxis was treated with self-injected adrenaline (epinephrine).Main outcome measuresChange in HRQL and self-efficacy.Results56 participants had reactions at food challenge, of whom 16 (29%) had anaphylaxis. Overall, there was an improvement in HRQL (mean 2.6 points (95% CI 0.3 to 4.8); p=0.030) and self-efficacy (mean 4.1 points (95% CI 2.4 to 5.9); p<0.0001), independent of whether anaphylaxis occurred. Parents also reported improved HRQL (mean 10.3 points (95% CI 5.9 to 14.7); p<0.0001). We found evidence of discordance between the improvement in HRQL and self-efficacy as reported by young people and that perceived by parents in their child.ConclusionsAnaphylaxis at food challenge, followed by self-administration of injected adrenaline, was associated with an increase in HRQL and self-efficacy in young people with peanut allergy. We found no evidence that the occurrence of anaphylaxis had a detrimental effect. Young people should be encouraged to self-administer adrenaline using their autoinjector device to treat anaphylaxis at in-hospital challenge.Trial registration numberNCT02149719
Prospective multicentre multifaceted before-after implementation study of ICU delirium guidelines: a process evaluation
Authors: Trogrlic Zoran , van der Jagt Mathieu , van Achterberg Theo , Ponssen Huibert , Schoonderbeek Jeannette , Schreiner Frodo , Verbrugge Serge , Dijkstra Annemieke , Bakker Jan , Ista Erwin 
Published: September 2020

ObjectiveWe aimed to explore: the exposure of healthcare workers to a delirium guidelines implementation programme; effects on guideline adherence at intensive care unit (ICU) level; impact on knowledge and barriers, and experiences with the implementation.DesignA mixed-methods process evaluation of a prospective multicentre implementation study.SettingSix ICUs.Participants4449 adult ICU patients and 500 ICU professionals approximately.InterventionA tailored implementation programme.Main outcome measureAdherence to delirium guidelines recommendations at ICU level before, during and after implementation; knowledge and perceived barriers; and experiences with the implementation.ResultsFive of six ICUs were exposed to all implementation strategies as planned. More than 85% followed the required e-learnings; 92% of the nurses attended the clinical classroom lessons; five ICUs used all available implementation strategies and perceived to have implemented all guideline recommendations (>90%). Adherence to predefined performance indicators (PIs) at ICU level was only above the preset target (>85%) for delirium screening. For all other PIs, the inter-ICU variability was between 34% and 72%. The implementation of delirium guidelines was feasible and successful in resolving the majority of barriers found before the implementation. The improvement was well sustained 6 months after full guideline implementation. Knowledge about delirium was improved (from 61% to 65%). The implementation programme was experienced as very successful.ConclusionsMultifaceted implementation can improve and sustain adherence to delirium guidelines, is feasible and can largely be performed as planned. However, variability in delirium guideline adherence at individual ICUs remains a challenge, indicating the need for more tailoring at centre level.
Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression
Authors: Wang Liang , Hu Yi-Yang , Zhao Jun-Long , Huang Fei , Liang Shi-Qian , Dong Lei , Chen Yan , Yu Heng-Chao , Bai Jian , Yang Jia-Meng , Fan Jie-Yi , Feng Lei , Li San-Zhong , Han Hua , Qin Hong-Yan 
Published: September 2020

BackgroundAccumulating evidence has shown that tumor-associated macrophages (TAMs) play a critical role in tumor progression. Targeting TAMs is a potential strategy for tumor immunotherapy. However, the mechanism underlying the TAM phenotype and function needs to be resolved. Our previous studies have demonstrated that miR-125a can reverse the TAM phenotype toward antitumor. Meanwhile, we have found that miR-125a and miR-99b cluster in the first intron of the same host gene, and are transcribed simultaneously in bone marrow-derived macrophages (BMDMs) following LPS+IFNγ stimulation. However, it remains unclear whether miR-99b by itself can exert an antitumor effect by regulating macrophage phenotype.MethodsmiR-99b and/or miR-125a were delivered into TAMs of orthotopic hepatocellular carcinoma (HCC) or subcutaneous Lewis lung cancer (LLC) mice. The effect of treatment was evaluated by live imaging, TUNEL staining and survival tests. The phenotype of the immune cells was determined by qRT-PCR, ELISA, western blot and FACS. The capability of miR-99b-mediated macrophage phagocytosis and antigen presentation was detected by FACS and immunofluorescence staining. The underlying molecular mechanism was examined by qRT-PCR, reporter assay and western blot, and further verified in the tumor model. The expression of miR-99b and its target genes was determined in TAMs sorted from tumor and adjacent tissues in patients with liver cancer.ResultsTargeted delivery of miR-99b and/or miR-125a into TAMs significantly impeded the growth of HCC and LLC, especially after miR-99b delivery. More importantly, the delivery of miR-99b re-educated TAM toward antitumor phenotype with enhanced immune surveillance. Further investigation of mechanisms showed that macrophage-specific overexpression of miR-99b promoted M1 while suppressing M2 macrophage polarization by targeting κB-Ras2 and/or mTOR, respectively. miR-99b-overexpressed M1 macrophage was characterized by stronger capability of phagocytosis and antigen presentation. Additionally, delivery of simTOR or siκB-Ras2 into TAMs inhibited miR-99b antagomir-triggered tumor growth. Finally, miR-99b expression was lower in TAMs of patients with liver cancer than that in adjacent tissues, while the expression of κB-Ras2 and mTOR was reversed.ConclusionsOur results reveal the mechanism of miR-99b-mediated TAM phenotype, indicating that TAM-targeted delivery of miR-99b is a potential strategy for cancer immunotherapy.
Coleman–Weinberg potential in p-adic field theory
Authors: Ageev Dmitry S. , Bagrov Andrey A. , Iliasov Askar A. 
Published: September 2020

AbstractIn this paper, we study$$\lambda \phi ^4$$λϕ4scalar field theory defined on the unramified extension of p-adic numbers$${\mathbb {Q}}_{p^n}$$Qpn. For different “space-time” dimensionsn, we compute one-loop quantum corrections to the effective potential. Surprisingly, despite the unusual properties of non-Archimedean geometry, the Coleman–Weinberg potential of p-adic field theory has structure very similar to that of its real cousin. We also study two formal limits of the effective potential,$$p \rightarrow 1$$p→1and$$p \rightarrow \infty $$p→∞. We show that the$$p\rightarrow 1$$p→1limit allows to reconstruct the canonical result for real field theory from the p-adic effective potential and provide an explanation of this fact. On the other hand, in the$$p\rightarrow \infty $$p→∞limit, the theory exhibits very peculiar behavior with emerging logarithmic terms in the effective potential, which has no analogue in real theories.
Analysis of threats and security issues evaluation in mobile P2P networks
Authors: Mohammed Ali Abdulwahhab , Kadhim Dheyaa Jasim 
Published: September 2020

Technically, mobile P2P network system architecture can consider as a distributed architecture system (like a community), where the nodes or users can share all or some of their own software and hardware resources such as (applications store, processing time, storage, network bandwidth) with the other nodes (users) through Internet, and these resources can be accessible directly by the nodes in that system without the need of a central coordination node. The main structure of our proposed network architecture is that all the nodes are symmetric in their functions. In this work,
the security issues of mobile P2P network system architecture such as (web threats, attacks and encryption) will be discussed deeply and then we propose different approaches and we analysis and evaluation of these mobile P2P network security issues and submit some proposal solutions to resolve the related problems with threats and other different attacks since these threats and attacks will be serious issue as networks are growing up especially with mobility attribute in current P2P networks.
Multi-objective Pareto front and particle swarm optimization algorithms for power dissipation reduction in microprocessors
Authors: Sulaiman Diary R. 
Published: September 2020

The progress of microelectronics making possible higher integration densities, and a considerable development of on-board systems are currently undergoing, this growth comes up against a limiting factor of power dissipation. Higher power dissipation will cause an immediate spread of generated heat which causes thermal problems. Consequently, the system's total consumed energy will increase as the system temperature increase.
High temperatures in microprocessors and large thermal energy of computer systems produce huge problems of system confidence, performance, and cooling expenses. Power consumed by processors are mainly due to the increase in number of cores and the clock frequency, which is dissipated in the form of heat and causes thermal challenges for chip designers. As the microprocessor’s performance has increased remarkably in
Nano-meter technology, power dissipation is becoming non-negligible. To solve this problem, this article addresses power dissipation reduction issues for high performance processors using multi-objective Pareto front (PF), and particle swarm optimization (PSO) algorithms to achieve power dissipation as a prior computation that reduces the real delay of a target microprocessor unit. Simulation is verified the conceptual fundamentals and optimization of joint body and supply voltages (Vth-VDD) which showing satisfactory findings.
Use of a Novel Septal Occluder Device for Left Atrial Appendage Closure in Patients With Postsurgical and Postlariat Leaks or Anatomies Unsuitable for Conventional Percutaneous Occlusion
Authors: Della Rocca Domenico G. , Horton Rodney P. , Tarantino Nicola , Van Niekerk Christoffel Johannes , Trivedi Chintan , Chen Qiong , Mohanty Sanghamitra , Anannab Alisara , Murtaza Ghulam , Akella Krishna , Gianni Carola , Bassiouny Mohamed , Ahmadian-Tehrani Ashkan , Al-Ahmad Amin , Burkhardt J. David , Natale Veronica N. , Price Matthew , Gallinghouse G. Joseph , Gibson Douglas N. , Lakkireddy Dhanunjaya , Di Biase Luigi , Natale Andrea 
Published: September 2020

Background:
Interventional therapies aiming at excluding the left atrial appendage (LAA) from systemic circulation have been established as a valid alternative to oral anticoagulation in patients at high thromboembolic risk. However, their efficacy on stroke prophylaxis may be compromised owing to incomplete LAA closure. Additionally, the need for an alternative thromboembolic prevention may remain unmet in patients with contraindications to oral anticoagulation whose appendage anatomy is unsuitable for some conventional devices commercially available. We aimed at evaluating the feasibility of LAA closure with the novel Gore Cardioform Septal Occluder in patients with incomplete appendage ligation or anatomic features which do not meet the manufacturer’s requirements for Watchman deployment.

Methods:

Twenty-one consecutive patients (mean age: 72±6 years; 85.7% males; CHA
2
DS
2
-VASc: 4.5±1.4; HAS-BLED: 3.6±1.0) were included. Transesophageal echocardiography was performed within 2 months to assess for residual LAA patency.

Results:
Fourteen patients had incomplete LAA closure following surgical (n=6) or Lariat ligation (n=8). In 7 patients with an appendage anatomy unsuitable for Watchman deployment, the mean maximal landing zone size and LAA depth were 14.4±1.3 and 18.6±2.8 mm. Successful Cardioform Septal Occluder deployment was achieved in all patients. No peri-procedural complications were documented. Procedure and fluoroscopy times were 46±13 and 14±5 minutes. Follow-up transesophageal echocardiography after 58±9 days revealed complete LAA closure in all patients.

Conclusions:
Transcatheter LAA closure via a Cardioform Septal Occluder device might be a valid alternative in patients with residual leaks following failed appendage ligation or whose LAA anatomy does not meet the minimal anatomic criteria to accommodate a Watchman device.

Graphic Abstract:

A
graphic abstract
is available for this article.
TRaNsMOGRiFiER: Fictional Narratives as Catalyst for Experimental Instrument-Building and Musical/Artistic Collaboration
Authors: Ferguson John R. , Bussigel Peter 
Published: September 2020

AbstractThe authors report on their artistic research project TRaNsMOGRiFiER and highlight musician-specific approaches to creating with technology that privilege the sharing of tools and practical knowledge. The use of fictional narratives as a catalyst for instrument-building and art-making is at the foreground of the discussion. By rethinking DIY/maker culture with an emphasis on collaboration and collective creativity, the authors highlight the tension between the production of fixed media output and practices that resist encapsulation. TRaNsMOGRiFiER underscores the benefits of hands-on learning and presents a collaborative artistic platform with a focus on open-ended processes and ongoing change.
Hemodynamic Changes with 1:1000 Epinephrine on Wrung-Out Pledgets Before and During Sinus Surgery
Authors: Peleman John R. , Tarwade Pritee , Han Xiaoxia , Penning Donald H. , Craig John R. 
Published: September 2020

Background: Intranasal topical 1:1000 epinephrine has been used safely and effectively for hemostasis during endoscopic sinus surgery (ESS). Prior studies assessing hemodynamic changes after intranasal topical epinephrine application have only used soaking wet cottonoid pledgets, and have only assessed for hemodynamic changes before any surgery being performed. Objective: The purposes of this study were to determine whether intranasal application of topical 1:1000 epinephrine with wrung-out cottonoid pledgets caused significant hemodynamic changes both before and during ESS, and whether it allowed for adequate hemostasis. Methods: A prospective evaluation of 30 patients with eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) undergoing complete bilateral ESS was conducted. Heart rate, blood pressure (systolic, diastolic, and mean arterial pressure), and electrocardiography changes were recorded at 0, 1, 2, and 5-minute intervals after placing wrung-out epinephrine-saturated pledgets, both before and at the end of ESS. No submucosal epinephrine injections were performed. Estimated blood loss (EBL) and major intraoperative complications were recorded for all cases. Results: There were no significant hemodynamic changes or electrocardiographic abnormalities after placement of wrung-out epinephrine-soaked pledgets both before and after ESS. After bilateral ESS, there were actually mean decreases in heart rate and blood pressure parameters. Mean EBL was 75.8 ± 32.2 mL, and no major intraoperative complications occurred. Conclusion: Intranasal application of topical 1:1000 epinephrine via wrung-out cottonoid pledgets was effective for intraoperative hemostasis, and did not cause clinically significant alterations in hemodynamic parameters or cardiovascular events, either before or during ESS in patients with CRSwNP. Level of Evidence: 4