bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le bien-être de l’enfant : évolution
d’une notion, ambiguïtés des dimensions et mesures
Authors: Martin Claude , Perron Zoé , Buzaud Julia 
Published: March 2020

Cadre de la recherche : Cet article
propose une revue de la littérature sur les déterminants et la mesure du
bien-être des enfants, et une analyse secondaire de bases de données
internationales dans le but de repérer des questions encore relativement
inexpliquées.
Objectifs : Il vise à proposer des
hypothèses pour expliquer les écarts entre le niveau d’investissement public
dans des politiques visant les enfants et leur niveau de bien-être
subjectif.
Méthodologie : Cette enquête repose sur
une revue de questions et des analyses secondaires de bases de données
internationales.
Résultats : L’article met en lumière
l’importance de la communication entre parents et adolescents dans le sentiment
de bien-être subjectif exprimé par les adolescents.
Conclusions : Des recherches
qualitatives et comparatives sont nécessaires pour mieux saisir les mécanismes
en cause.
Contribution : Les travaux
de la chaire CNAF-EHESP « Enfance, bien-être, parentalité » sur lesquels
s’appuient cet article permettent de s’interroger sur l’engouement actuel pour
les questions de bien-être et de bonheur des populations afin d’améliorer leur
compréhension par les sciences sociales
Impact of breast surgery on survival of patients with stage IV breast cancer: a SEER population-based propensity score matching analysis
Authors: Lin Yuxiang , Huang Kaiyan , Zeng Qiang , Zhang Jie , Song Chuangui 
Published: March 2020

Background
Breast surgery for stage IV breast cancer remains controversial. The aim of this study was to investigate the impact of breast surgery on survival of stage IV breast cancer patients based on the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015.

Methods
In total, 13,034 patients were selected and divided into surgery and non-surgery groups. Univariate and multivariable analyses were conducted to determine factors related to survival. Propensity score matching method was utilized to achieve balanced covariates across different groups. One-to-one (1:1) PSM was conducted to construct a matched sample consisting of pairs of surgery and non-surgery subjects. Breast cancer-specific survival (BCSS) and overall survival (OS) of the two groups were assessed by Kaplan–Meier plots and Cox proportional hazard regression models. Stratified analysis according to different variables was also performed.

Results
Patients treated with breast surgery were more likely to be younger, smaller tumor size, more advanced nodal status, higher histology grade and higher proportion of bone-only metastasis. Those who received chemotherapy and radiotherapy also tended to be treated with surgery. After adjustment for potential confounders, breast surgery group exhibited a better survival both in BCSS (HR = 0.557, 95% CI [0.523–0.594], p < 0.001) and OS (HR = 0.571, 95% CI [0.537–0.607], p < 0.001). After propensity score matching, the surgery and non-surgery group consisted of 2,269 patients respectively. The median survival time was 43 months for the surgery group and 27 months for the non-surgery group. Kaplan–Meier curves indicated that breast surgery could clearly improve both the BCSS and OS for patients with stage IV breast cancer. On multivariate analysis, surgery group was associated with a better survival compared with the non-surgery group (BCSS: HR = 0.542, 95% CI [0.499–0.589], p < 0.001; OS: HR = 0.555, 95% CI [0.512–0.601], p < 0.001). Furthermore, this survival advantage persisted in all subgroups irrespective of age, race, tumor size, nodal status, histology grade, molecular subtype, chemotherapy status, radiotherapy status or status of distant metastasis.

Conclusion
Our study provided additional evidence that patients with stage IV breast cancer could benefit from breast surgery and it might play a more important role in multimodality therapy.
Icariin affects cell cycle progression and proliferation of human retinal pigment epithelial cells via enhancing expression of H19
Authors: Zhang Yibing , Li Min , Han Xue 
Published: March 2020

Background
Aberrant proliferation of retinal pigment epithelial (RPE) cells under pathologic condition results in the occurrence of proliferative vitreoretinopathy (PVR). Icariin (ICA)-a flavonol glucoside-has been shown to inhibit proliferation of many cell types, but the effect on RPE cells is unknown. This study aimed to clarify the inhibitory effects of ICA on RPE cells against platelet-derived growth factor (PDGF)-BB-induced cell proliferation, and discuss the regulatory function of H19 in RPE cells.

Methods
MTS assay was conducted to determine the effects of ICA on cell proliferation. Flow cytometry analysis was performed to detect cell cycle progression. Quantitative real-time PCR and western blot assay were used to measure the expression patterns of genes in RPE cells.

Results
ICA significantly suppressed PDGF-BB-stimulated RPE cell proliferation in a concentration-dependent manner. Moreover, since administration of ICA induced cell cycle G0/G1 phase arrest, the anti-proliferative activity of ICA may be due to G0/G1 phase arrest in RPE cells. At molecular levels, cell cycle regulators cyclin D1, CDK4, CDK6, p21 and p53 were modulated in response to treatment with ICA. Most importantly, H19 was positively regulated by ICA and H19 depletion could reverse the inhibitory effects of ICA on cell cycle progression and proliferation in PDGF-BB-stimulated RPE cells. Further mechanical explorations showed that H19 knockdown resulted in alternative expressions levels of cyclin D1, CDK4, CDK6, p21 and p53 under ICA treatment.

Conclusions
Our findings revealed that ICA was an effective inhibitor of PDGF-BB-induced RPE cell proliferation through affecting the expression levels of cell cycle-associated factors, and highlighted the potential application of ICA in PVR therapy. H19 was described as a target regulatory gene of ICA whose disruption may contribute to excessive proliferation of RPE cells, suggesting that modulation of H19 expression may be a novel therapeutic approach to treat PVR.
The combined effects of temperature and aromatase inhibitor on metamorphosis, growth, locomotion, and sex ratio of tiger frog (Hoplobatrachus rugulosus) tadpoles
Authors: Tang Yun , Chen Zhi-Qiang , Lin You-Fu , Chen Jing-Yi , Ding Guo-Hua , Ji Xiang 
Published: March 2020

BackgroundThe tiger frog (Hoplobatrachus rugulosus) is widely raised by many farms in southern region of China as an economically edible frog. The growth, development, and sexual differentiation of amphibians are influenced by temperature and steroid hormone level. However, the problem of hormone residues is caused by the addition of exogenous hormones in frog breeding, it is worth considering whether non-sterol aromatase inhibitors can be used instead of hormones.MethodsIn our study,H. rugulosustadpoles were subjected to two water temperatures (29 °C and 34 °C) and three letrozole concentrations in the feed (0, 0.1 and 1 mg/g) to examine the effects of temperature, aromatase inhibitor and their interaction on metamorphosis, locomotion, and sex ratios. AG-test and contingency table were used to analyze the metamorphosis rate of tadpoles and the survival rate of froglets after feeding for 90 days. AG-test was also used to analyze sex ratios in different treatment groups.ResultsMetamorphosis time and body size (snout–vent length, body mass and condition factor) were significantly different between the two temperature treatments. Metamorphosis time was longer and body size was increased at 29 °C compared to those at 34 °C. Letrozole concentration and the temperature × letrozole interaction did not affect these variables. The jumping distance of froglets following metamorphosis was positively associated with the condition factor; when controlling for condition factor, jumping distance was not affected by temperature, letrozole concentration and their interaction. Temperature and letrozole concentration also did not affect metamorphosis and survival rate. Sex ratio of the control group (0 mg/g letrozole) was 1:1 at 29 °C, but there were more males at 34 °C. The sex ratios ofH. rugulosustreated with letrozole at 29 °C and 34 °C were significantly biased toward males, and male ratio increased as letrozole concentration increased. Furthermore, more males were produced at 34 °C than at 29 °C at each letrozole concentration.
Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis
Authors: Guo Dongmei , Wang Hongchun , Sun Li , Liu Shuang , Du Shujing , Qiao Wenjing , Wang Weiyan , Hou Gang , Zhang Kaigang , Li Chunpu , Teng Qingliang 
Published: March 2020

Purpose
Mantle cell lymphoma (MCL) is a rare and aggressive subtype of non-Hodgkin lymphoma that is incurable with standard therapies. The use of gene expression analysis has been of interest, recently, to detect biomarkers for cancer. There is a great need for systemic coexpression network analysis of MCL and this study aims to establish a gene coexpression network to forecast key genes related to the pathogenesis and prognosis of MCL.

Methods
The microarray dataset GSE93291 was downloaded from the Gene Expression Omnibus database. We systematically identified coexpression modules using the weighted gene coexpression network analysis method (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were performed on the modules deemed important. The protein–protein interaction networks were constructed and visualized using Cytoscape software on the basis of the STRING website; the hub genes in the top weighted network were identified. Survival data were analyzed using the Kaplan–Meier method and were compared using the log-rank test.

Results
Seven coexpression modules consisting of different genes were applied to 5,000 genes in the 121 human MCL samples using WGCNA software. GO and KEGG enrichment analysis identified the blue module as one of the most important modules; the most critical pathways identified were the ribosome, oxidative phosphorylation and proteasome pathways. The hub genes in the top weighted network were regarded as real hub genes (IL2RB, CD3D, RPL26L1, POLR2K, KIF11, CDC20, CCNB1, CCNA2, PUF60, SNRNP70, AKT1 and PRPF40A). Survival analysis revealed that seven genes (KIF11, CDC20, CCNB1, CCNA2, PRPF40A, CD3D and PUF60) were associated with overall survival time (p < 0.05).

Conclusions
The blue module may play a vital role in the pathogenesis of MCL. Five real hub genes (KIF11, CDC20, CCNB1, CCNA2 and PUF60) were identified as potential prognostic biomarkers as well as therapeutic targets with clinical utility for MCL.
Dust Pollution Reduced Stomatal Conductance and Photosynthetic Pigments of Selected Medicinal Plants Growing at Lokpa Ukwu Quarry Site in Abia State, Nigeria
Authors: Ogbonna C. E. , Nwafor F. I. , Nweze N. O. 
Published: March 2020

Aims: We investigated the influence of dust pollution on stomatal conductance and photosynthetic pigments in some medicinal plants growing at Lokpa Ukwu quarry site, Abia State, Nigeria.
Place and Duration of Study: Samples were collected from Lokpa Ukwu, Abia State while laboratory analyses were carried out in the Department of Pharmacognosy and Environmental Medicines, University of Nigeria, Nsukka between February and April, 2019.
Methodology: A total of nine (9) plants were sampled for the study. Leaf epidermises were prepared by clearing method and stomata were observed and studied quantitatively. Stomatal conductance was estimated from the anatomical variables following standard procedures. Total chlorophyll and β-carotene contents were also analysed and compared with control groups.
Results: We observed some physiological changes in the plants from dust-polluted site such as stretched epidermal cells, deformed stomata and plasmolysed guard cells. It reduced the potential conductance indices (PCI) of the plants by 87.4% in Aspilia africana and 67% in Chromolaena odorata. The least reduction in PCI was observed in Celosia trigyna (7.2%). Operating conductance (gop) and maximum conductance (gmax) were reduced by 69.2% and 72.3% in C. odorata and A. africana respectively. Celosia trigyna was least affected with percentage reductions of 18.3% and 1.4% for gop and gmax respectively. Reduction in PCI and gmax followed the order: C. trigyna ˂ C. papaya ˂ P. discoideus ˂ D. oliveri ˂ T. rhomboidea ˂ T. orientalis ˂ V. doniana ˂ C. odorata ˂ A. africana. Total chlorophyll and β-carotene contents were reduced the most in V. doniana (45.73%) and C. odorata (40.31%) respectively and least reduced in T. orientalis by 19.54% and 13.24% respectively.
Conclusion: Our findings validate previous reports of negative effects of dust pollution from quarry industries on both humans and plants alike.
Serodetection Bovine Herpesvirus Types 1, 4 and Bovine Parainfluenza Virus Type 3 Infections in Milk of Cows with Clinical Mastitis Based in Dairy Cattle Management in Turkey
Authors: Celik Bayram , Kale Mehmet 
Published: March 2020

Aims: The present study aimed to Searching Bovine Herpesvirus Types 1, 4 and Bovine Parainfluenza Virus Type 3 Infections in Milk of Cows with Clinical Mastitis Based in Dairy Cattle Managements.
Study Design: In 35 managements around Burdur region, milk of 123 cows with clinical mastitis was searched for Bovine Herpesvirus Types 1 (BHV-1), 4 (BHV-4) and Bovine Parainfluenza Virus Type 3 (BPIV-3) infections.
Results: In the study, the highest seropositivity was detected against BPIV-3. The highest seropositivity on infection distribution according to age was found against every four viruses in animals within the three-year-old group. The highest seropositivity in this group and other age groups was detected against BPIV-3. Seropositivity against these viruses was found in the highest right anterior one and the lowest left posterior one out of determined udder lobes. The highest seropositivity was found in semi-outdoor managements with concrete and dirty grounds where cleaning/disinfection of teats before and after milking was performed, mastitis treatment and viral vaccination was not applied, the ground of stable was cleaned monthly, only feces was collected from the grounds, water was used for cleaning of milking machines and hands and iodised disinfectant was used. During udder inspection evaluation of animals with clinical mastitis, the highest seropositivity was detected in the ones having normal udder, teat and skin appearance. Out of udder and teat skin lesions, the highest seropositivity was found in crushed ones. In the evaluation of udder palpation in animals with clinical mastitis, the highest seropositivity was detected in the ones with teat tissue thickening and with elastic teat sinuses and lobes. In the milk of these animals, the highest seropositivity was found in the ones showing coagulation.
Conclusion: It was stated that viruses took a vital part in clinical mastitis cases, the structure, practice, cleaning and disinfection of managements was really important, udder and teat skin lesions, tissue thickening, elastic teat sinuses and lobes and coagulation of milk was also crucial. Besides, the appearance of udder, teat and skin was not relevant.
Prenatal Tobacco Exposure, Brain Subcortical Volumes, and Gray-White Matter Contrast
Authors: Puga Troy B. , Doucet Gaelle E. , Thiel Grace E. , Theye Elijah , Dai Hongying Daisy 
Published: December 2024

ImportanceMaternal tobacco use during pregnancy (MTDP) remains a major public health challenge. However, the complete spectrum of effects of MTDP is not fully understood.ObjectivesTo examine the longitudinal associations of MTDP and children’s brain morphometric subcortical volume and gray-white matter contrast (GWC) development.Design, Setting, and ParticipantsCohort study of children aged 9 to 10 years at wave 1 (October 2016 to October 2018) and at a 2-year follow-up (wave 2; August 2018 to January 2021; aged 11-12 years) across 21 US sites in the Adolescent Brain Cognitive Development (ABCD) Study. Data were analyzed from October 2023 to October 2024.ExposureMTDP.Main outcomes and measuresMorphometric brain measures of subcortical volume and GWC.ResultsAmong the 11 448 children (51.5% male; 13.1% Black; 24.0% Hispanic; and 52.9% White) at wave 1, 1607 (16.6%; 95% CI, 13.0%-20.2%) were identified with MTDP exposure. At wave 1, children with MTDP exposure (vs no exposure) exhibited lower GWC in widespread brain regions primarily located in the frontal (eg, superior frontal; regression coefficient [B] = −0.0019; SE, 0.0006; P = .004), parietal (eg, supramarginal; B = −0.0021; SE, 0.0007; P = .002) and temporal lobes (eg, middle temporal; B = −0.0024; SE, 0.0007; P &amp;lt; .001). These differences in GWC continued to be significant at wave 2. In regard to subcortical volume, children with MTDP exposure demonstrated smaller volume of the lateral ventricle (B = −257.5; SE, 78.6; P = .001) and caudate (B = −37.7; SE, 14.0; P = .01) in the left hemisphere at wave 1, and lower volume of the caudate in both left (B = −48.7; SE, 15.9; P = .002) and right hemisphere (B = −45.5; SE, 16.1; P = .01) at wave 2.Conclusions and RelevanceThis cohort study found that MTDP exposure was associated with lower GWC across the whole cortex and smaller caudate nuclei volume compared with no exposure, signifying the importance of preventing MTDP and necessitating further research on this topic.
Symptoms, Quality of Life, and Executive Function in Children Who Snore
Authors: Yu Phoebe K. , Cook Kaitlyn , Tapia Ignacio E. , Ross Kristie R. , Ibrahim Sally , Amin Raouf , Ishman Stacey L. , Hassan Fauziya , Chervin Ronald D. , Liu Christopher , Mitchell Ron B. , Stone Laura , Taylor H. Gerry , Radcliffe Jerilynn , Redline Susan , Baldassari Cristina M. 
Published: December 2024

IntroductionMild sleep-disordered breathing (mSDB) in children is associated with both neurobehavioral morbidity and reduced quality of life (QOL). However, the association between symptom burden and QOL with executive function is not well understood, and it is not known whether QOL and symptom burden may help identify children with neurocognitive dysfunction.ObjectiveTo assess associations among executive function, QOL, and symptom burden in children with mSDB.Design, Setting, and ParticipantsThis cross-sectional study was a secondary analysis of the multicenter Pediatric Adenotonsillectomy Trial for Snoring, which included children aged 3 to 12 years randomized to watchful waiting or adenotonsillectomy for mSDB (snoring and an obstructive apnea-hypopnea index &amp;lt;3) between June 29, 2016, and February 1, 2021. The data for this report were analyzed between December 22, 2020, and October 3, 2024.ExposurePediatric mSDB.Main Outcomes and MeasuresQuality of life was assessed using the Obstructive Sleep Apnea–18 (OSA-18), and symptom burden was assessed using the Pediatric Sleep Questionnaire–Sleep-Related Breathing Disorder Scale (PSQ-SRBD). Executive function, including self-control and working memory, was measured using the Behavior Rating Inventory of Executive Function Global Executive Composite (BRIEF GEC), and inhibitory control and sustained attention were measured by the GoNoGo vigilance test. Partial Pearson correlations and multiple linear regression models were used to assess the associations among QOL, symptoms, and executive function.ResultsThe sample included 459 children (mean [SD] age, 6.1 [2.3] years; 230 female [50.1%]). Moderate correlations were found between the BRIEF GEC and the PSQ-SRBD and OSA-18 (r = 0.58 [95% CI, 0.51-0.64] and 0.59 [95% CI, 0.52-0.64], respectively). After adjusting for age, sex, race and ethnicity, body mass index percentile, household income, maternal education, attention-deficit/hyperactivity disorder, test characteristics, and disease severity, both OSA-18 and PSQ-SRBD scores were associated with the BRIEF GEC (β = 0.41 [95% CI, 0.36-0.47] and 3.66 [95% CI, 3.17-4.15], respectively). In the fully adjusted model, PSQ-SRBD was also associated with GoNoGo inhibitory control (β = −0.04 [95% CI, −0.08 to −0.01]) and sustained attention (β = −0.05 [95% CI, −0.10 to −0.01]).Conclusions and RelevanceIn this study, disease-specific QOL and symptom burden were associated with executive function in children with mSDB. These findings may be useful in identifying those children who are at risk for neurocognitive dysfunction.
Engineered Bacteria Manipulate Cysteine Metabolism to Boost Ferroptosis‐Based Pancreatic Ductal Adenocarcinoma Therapy
Authors: Qiao Chaoqiang , Wang Lexuan , Huang Chuting , Jia Qian , Bao Weier , Guo Peilin , Tan Dengxu , Chen Zhuang , Shi Changhong , Rao Zhiping , Zhang Ruili , Wei Wei , Wang Zhongliang 
Published: December 2024

AbstractCysteine metabolism is a key determinant of the defense against ferroptosis in pancreatic ductal adenocarcinoma (PDAC). Blocking cysteine metabolism may trigger potent ferroptosis in PDAC cells by generating lipid peroxides during tumor metabolic processes. However, current methods to limit cysteine availability fall short, failing to efficiently block cysteine metabolism due to inadequate tumor targeting and compensatory cysteine sources. Inspired by sulfur‐metabolizing bacteria, synthetic biology to develop an engineered bacterium capable of directly depleting cysteine to block its metabolism is used. Acting as a living drug, these engineered bacteria colonize the tumor and continuously produce engineered cyst(e)inase enzyme (CGL) under the stimulation of tumor hypoxia. The CGL exhausts the substrate cysteine, completely impeding cysteine metabolism. This process dismantles the ferroptosis defense system in PDAC cells, triggers potent ferroptosis, and achieves efficient treatment. The results demonstrate that engineered bacteria designed for cysteine metabolism modulation possess unparalleled advantages in efficacy, persistence, and precision in blocking cysteine metabolism, making them highly suitable for effective ferroptosis treatment of PDAC.
Molecular Imaging of Ovarian Follicles and Tumors With Near‐Infrared II Bioconjugates
Authors: Wang Yicong , Lu Wenhan , Chen Zi‐Han , Xiao Yan , Wang Yu , Gao Wenhao , Wang Zhiming , Song Ruihu , Fang Zhao , Hu Wei , Tong Xiaoyu , Lee Kuinyu , Pei Zhenle , Xu Minzhen , Zhang Fan , Chen Hao , Feng Yi 
Published: December 2024

AbstractFollicular tracking is typically conducted using ultrasound technology, but its effectiveness is constrained by limited resolution. High‐resolution imaging of deep tissues can be accomplished using luminescence imaging in the near‐infrared II window (NIR‐II, 1000–1700 nm); however, the contrast agents that are used lack specificity. Here, it is reported that the FDA‐approved indocyanine green (ICG)‐conjugated recombinant human chorionic gonadotropin (hCG) protein can target early follicles with long‐term effectiveness. A novel high‐resolution NIR‐II imaging approach is developed for monitoring follicular development as well as ovulation using multi‐color imaging of ovarian vessels with a combination of non‐overlapping downconversion nanoparticles (DCNPs). The results showed that the ability to monitor early follicles of around 50 µm in diameter exceeded the spatial and temporal resolution of ultrasound or MRI without the reproductive damage associated with computed tomography radiation, and this enabled the clinical identification of the follicular reserve in patients with infertility diseases such as polycystic ovary syndrome (PCOS). In addition, NIR‐II imaging clearly targeted ovarian tumors and showed micro‐metastatic lesions, thus providing a new tool for monitoring tumors in vivo and guiding surgical resection.