bluuebunny/crossref_metadata_2025_split huggingface dataset:
A process innovation mode of semiconductor integrated circuit products based on the integration of Internet of things and sensing big data
Authors: Huang Yin , Huang Shumin , Zhang Yichen , Sheng Sishi , Yang Xue , Liu Runda 
Published: December 2019

OBJECTIVE: At present, Internet of things (IoT) technologies such as radio frequency identification devices (RFID) have been widely used. In such context, manufacturing industries of semiconductor integrated circuits have gradually realised that it is necessary to integrate IoT technologies such as RFID with other systems of technologies. The research provides a new idea for the deep integration of IoT technologies including RFID with new-generation information technologies (IT) such as big data and deep learning and drives IoT technologies to develop with multiple functions and diverse types. DESIGN, METHODOLOGY, and APPROACH: The research takes the manufacturing enterprises of semiconductor integrated circuits as the objects and integrates IoT technologies involving RFID and intelligent sensors with new-generation IT technologies such as big data, sensing database, deep learning, knowledge discovery, etc. On this basis, a process innovation mode based on the integration of IoT and sensing big data is established. Based on the characteristics of sensing big data of enterprises manufacturing semiconductor integrated circuits, the innovation mode is designed in three stages including: data integration and fusion, data optimisation and modelling, and data application. Moreover, the system architecture, key technologies, modelling process, and algorithm design are also analysed. FINDINGS: A process innovation mode of semiconductor integrated circuit products based on the integration of IoT and sensing big data is provided.
The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson’s disease with dementia: Pilot study
Authors: Khedr Eman M. , Mohamed Khaled O. , Ali Anwar M. , Hasan Asmaa M. 
Published: December 2019

Background: The exact mechanism of cognitive impairment in PD is not known. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for cognitive impairment and to treat the motor symptoms in Parkinson’s disease (PD) where its effects seem additive to those of dopaminergic medications. Objective: In this pilot study we investigated whether repeated sessions of rTMS have an effect on measures of cognitive impairment in patients with PD dementia. Methods: 33 patients with PD dementia were randomly assigned sham or real rTMS (2000 pulses; 20 Hz; 90% RMT; 10 trains of 10 s with 25 s between each train) over the hand area of each motor cortex (5 min between hemispheres) for 10 days (5 days/week) followed by 5 booster sessions every month for 3 months. Assessments included the Unified Parkinson’s Disease Rating Scale part III (UPDRS), Montreal Cognitive Assessment (MoCA); Mini Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR); Memory and Executive Screening (MES) and Instrumental activity of Daily Living (IADL). Event related potentials (P300) and cortical excitability were measured before treatment and after the last session. Results: There were no significant differences in the effects of rTMS between groups. Although rTMS improved motor function in the active group it had only a minor effect on two of the dementia rating scores (the MMSE and MoCA) but not the others (CDR and MES). There was also a reduction in the latency of the P300 in the active group. Conclusions: rTMS over M1 is useful for motor function and may have a small positive effect on cognition. However, better approaches for the latter are necessary, may be require multisite rTMS to target both motor and frontal cortical region.
EVALUASI TERHADAP RUMUSAN PERNYATAAN PASTORAL PGI TENTANG LGBT
Authors: Hutabarat Binsar Antoni 
Published: December 2019

â€œEvaluasi terhadap Rumusan Pernyataan Pastoral Majelis Pekerja Harian PGI (Persekutuan Gereja-gereja di Indonesia)â€ 28 Mei 2016 tentang LGBT (lesbian, gay, biseksual, transgender) fokus pada evaluasi terhadap rumusan Pernyataan Pastoral MPH PGI yang berisi himbauan terhadap gereja-gereja anggota PGI, masyarakat dan negara. Evaluasi ini didasarkan pada konteks gereja-gereja anggota PGI yang terbagi dua, yakni gereja-gerejaÂ yang menolak orientasi seksual LGBT, dan sebagian lagi yang menerima orientasi seksual LGBT. Metode penelitian yang digunakan adalah metode evaluasi rumusan kebijakan, secara khusus tentang bagaimana proses perumusan kebijakan itu dihasilkan, dan isi dari rumusan kebijakan tersebut. Temuan tulisan ini adalah Pernyataan Pastoral MPH-PGI tentang LGBT merupakan rumusan kebijakan elite MPH-PGI yang lebih berpihak kepada kelompok-kelompok yang menerima orientasi seksual LGBT, dan kurang memerhatikan pandangan mereka yang menolak orientasi seksual LGBT.
PERIANAL INFECTIONS AS FIRST PRESENTATION OF HEMOBLASTOSIS AND APLASTIC ANEMIA
Authors: Shtyrkova S. V. , Karagyulyan S. R. , Gemdzhian E. G. , Ntanishyan K. I. 
Published: December 2019

AIM: to present clinical variability of perianal infection (PI), developed in the debut of oncohematological disease and to determine the factors that impede PI relief and time of antitumor treatment initiation, as well as the causes of complications during chemotherapy (ChT).PATIENTS AND METHODS: the analysis included 8 patients with an infectious process in the perianal region developed in the debut of hemoblastosis and aplastic anemia (before ChT).RESULTS: in 5 of 8 patients there was a long time between start of PI and the start of ChT for hemoblastosis, from 18 to 49 days. The impediment for a favorable time to start ChT were not clarified diagnosis of hemoblastosis (acute myeloid leukemia – 2 cases, multiple myeloma – 1, lymphoma – 1) and the ongoing infectious process in patients with severe granulocytopenia (GCP). Usually undetected hematological malignancies were observed in patients with compensated data of haemogram. Complications during ChT were associated with recurrence of PI in the area of surgery (palliative drainage of anorectal abscess and fistula-in-ano) and of the sepsis with persisted inflammation in the postoperative wound on the background of GCP.CONCLUSION: PI is one of the infectious complications peculiar for the debut of oncohematological disease. Therefore, a general blood test with leukocyte formula should be performed before surgery in all patients with paraproctitis to exclude hemoblastosis. The unknown diagnosis of hemoblastosis and the ineffectiveness of surgical treatment of paraproctitis in patients with severe GCP were the main reasons for the delay in the beginning of antitumor treatment in this study. Persistent infection (fistula-in-ano) and the persistent inflammation in the wound on the background of the GCP has resulted in the recurrence of PI and sepsis during chemotherapy.
FXYD5/Dysadherin, a Biomarker of Endometrial Cancer Myometrial Invasion and Aggressiveness: Its Relationship With TGF-β1 and NF-κB Pathways
Authors: Besso María José , Rosso Marina , Lapyckyj Lara , Moiola Cristian Pablo , Matos María Laura , Mercogliano María Florencia , Schillaci Roxana , Reventos Jaume , Colas Eva , Gil-Moreno Antonio , Wernicke Alejandra , Orti Roberto , Vazquez-Levin Mónica Hebe 
Published: December 2019

Objective: Endometrial cancer (EC) is the second most common gynecological cancer worldwide. Myometrial invasion (MI) is a key event in EC dissemination. This study aimed to evaluate FXYD5/dysadherin (FXYD5/Dys) expression in EC tissue and uterine aspirate (UA) biopsies and to assess molecular/functional changes associated with its expression in cellular models.Methods: FXYD5/Dys messenger RNA (mRNA) levels were determined in EC tissue and UA biopsies. FXYD5/Dys expression was evaluated in EC RNAseq data from The Cancer Genome Atlas (TCGA) and GENEVESTIGATOR tools. FXYD5/Dys impact on E-cadherin expression and cell behavior was assessed in EC Hec1a cells treated with transforming growth factor (TGF)-β1, stably transfected with ETV5, and transiently transfected with FXYD5/Dys small interfering RNA (siRNA) or pcDNA3-FXYD5/Dys plasmid.Results: FXYD5/Dys was associated with EC aggressiveness, finding high mRNA levels in tumors depicting MI &gt; 50%, Grade 3, and intermediate/high risk of recurrence. FXYD5/Dys was highly expressed at the tumor invasive front compared to the superficial area. Most results were recapitulated in UA biopsies. FXYD5/Dys modulation in Hec1a cells altered cell migration/adhesion and E-cadherin expression. TGF-β1 treatment of Hec1a cells induced FXYD5/Dys expression. TCGA-UCEC RNAseq analysis revealed a positive correlation between FXYD5/Dys, TGF-β1, and plasminogen activator inhibitor (PAI)-1 mRNA levels. FXYD5/Dys induced nuclear factor (NF)-κB pathway activation in Hec1a cells. FXYD5/Dys mRNA levels positively correlated with transcriptional activation of NF-κB p65-regulated genes. Survival analysis revealed patient segregation into low- and high-risk groups, the latter depicting the highest FXYD5/Dys, PAI-1, tumor necrosis factor (TNF)-α, and TGF-β1 mRNA levels and shorter survival rates.Conclusion: FXYD5/Dys is a novel biomarker of EC progression related to TGF-β1 and NF-κB pathways that collectively promote tumor dissemination and result in poor patient prognosis.
EVALUATION OF DRUG USE IN PATIENTS PREOPERATIVE AT CENTRAL SURGERYCAL INSTALLATION RSUD dr. SOEKARDJO TASIKMALAYA
Authors: Retnasari Irma 
Published: December 2019

<p><em>Surgical services are hospital services which often lead to medical injuries and complications such as wound infection (ILO) and anesthetic complications are becoming one of the most common causes of serious surgical complications. Provision of appropriate drug therapy, safe, effective and patient safety standards and monitoring operations can be reduces the incidence of complications and mortality of patients. The use of appropriate drug therapy, safe and effective can be determined by evaluation of the use of drugs. This study aims to describe the pattern of drug use and appropriateness of using the drug in patients in the preoperative surgical installation of central dr. Soekardjo Tasikmalaya which include proper indications, the exact dosage and drug interactions. This study is a cross-sectional, Data collection was done prospectively and statistical data. Data generated from the 120 patients who met the inclusion criteria preoperative inaccuracy indications showed 22.5%; inaccuracy dose of 22.9% and 87.5% of potential drug interactions.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: preoperative, drug use evaluation, Antibiotic prophylaxis, anesthesia</em><em>.</em></p>
UJI TOKSISITAS AKUT EKSTRAK BUAH OKRA (Abelmoschus esculatus L. Moench) TERHADAP PARAMETER KADAR SGOT DAN SGPT SERTA HISTOPATOLOGI HEPAR TIKUS GALUR WISTAR
Authors: Nurfatwa Maritsa 
Published: December 2019

<p><em>Okra (Abelmoschus esculatus l. Moench) fruit has been used empirically and scientifically proven to have effect to control blood cholesterol and blood glucose level. However, there has been no research on okra ethanol extract acute toxicity effect on hepatocyte. This research was aim to evaluate okra ethanol extract acute toxicity on liver using SGOT, SGPT and liver histopathology parameter after given 300 mg/kg bw (1 dose), 2000 mg/kg bw (dose 2) and 5000 mg/kg bw (3 doses) okra ethanol extract to female wistar rats. There were no significant differences on SGOT and SGPT level among all of experiment groups, but SGOT and SGPT increased along with increasing dosage. Histopathology showed no significant damage on hepatocytes. Okra ethanol extract has no acute toxic effect on the liver.</em></p><p><strong> </strong><strong><em>Keywords:</em></strong><strong><em> </em></strong><em>Okra, SGOT, SGPT, histopathology</em><em>.</em></p>
Kurumsal İktisatçı Olarak Hayek: Kültürel Evrim, Kurallar ve Kurumlar
Authors: LEVENT Adem 
Published: December 2019

Avusturya iktisat okulunun 20. yüzyıldaki en önemli düşünürlerinden biri hiç şüphesiz Friedrich August von Hayek’tir. Hayek kültürel evrim teorisiyle kurumsal iktisada katkı olarak değerlendirilebilecek gelişmiş bir kurallar teorisi sunar. Bu çalışma boyunca Hayek’in kurumsal iktisatçı olduğu iddia edilmiştir. Hayek’in kurumsal iktisatçı olarak ele alınması, iktisat ve modern sosyal teorinin kurumlar merkezli anlaşılması için önem arz ettiği kadar modern sosyal teorideki aktör-yapı ikiliğindeki metodolojik sorunların giderilmesine de katkı sunar. Aynı zamanda modern toplumdaki sosyal kurumların nasıl oluştuğunu da gösterir. Hayek’in bireyciliği, atomistik ve toplumdan izole edilmiş bir bireycilikten ziyade sosyal kurallar ve kurumlar analizine dayanan kendiliğinden gelişen düzene dayalıdır. Çalışmanın ana hedeflerinden biri Hayek’in kültürel evrim teorisinin kurumsal iktisat bağlamında analiz edilmesidir. Bu amaçla öncelikle Avusturya iktisadı ve kurumsal iktisat metodolojik açıdan karşılaştırılmıştır. Daha sonra Hayek’in kültürel evrim teorisi, kurumsal iktisat ve metodolojik bireycilik bağlamında detaylı analiz edilmiştir.
EDITORIAL
Authors: Quezada Meireles Leite Sidnei 
Published: December 2019

O número 3 de 2016 (volume 6) da Revista Eletrônica Debates em Educação Científica e Tecnológica reúne artigos e ensaios sobre a educação e o ensino produzidos em um dos seis eixos dessa revista científica, a saber: (a) Ensino de Ciências e Matemática; (b) Ensino de Humanidades; (c) Formação Inicial e Continuada de Professores da Educação Básica; (d) Tecnologias Educacionais e Recursos Didáticos; (e) Educação Profissional e Tecnológica; e (f) Diversidades e Inclusão Social. Os artigos tratam de propostas inovadoras de ensino, estudos sobre tecnologias educacionais e formação de professores no contexto da educação básica. Alguns dos trabalhos foram realizados em programas de pós-graduação stricto sensu da área de Ensino e da Educação, desenvolvidos tanto no âmbito nacional como, também, internacional. Também, a revista DECT está cadastrada no sistema Diadorim (Brasil) e já se encontra no banco de dados do Google Acadêmico, o que melhorou o processo de busca dos artigos nos aplicativos como Google, Bing e Yahoo.
Com a colaboração conjunta de professores do Programa de Pós-graduação em Educação em Ciências e Matemática (Educimat) e do Programa de Pós-graduação em Ensino de Humanidades (PPGEH), ambos da área 46 da CAPES – Ensino, a revista ampliou sua abordagem no campo do Ensino, passando a abordar estudos sobre metodologias educacionais, teorias de aprendizagem, formação de professores, uso de espaços de educação não formal, práticas pedagógicas abordando sustentabilidade, diversidades e inclusão social no contexto do ensino de história, geografia, filosofia, sociologia, artes e línguas, além dos estudos antes abordados no campo da educação científica.
A presença de alguns investigadores nas duas áreas Ensino desenvolvidas nos programas Educimat e PPGEH, produziram articulações impactaram na visão da Revista Eletrônica DECT, a qual muito gentilmente abraçou o horizonte de estudos científicos e tecnológicos no campo do ensino de humanidades. A criação desses dois programas foi uma conquista do Ifes e do Estado do Espírito Santo, para ampliar a formação de pessoas qualificadas e mentes criativas para pensar, planejar e executar projetos voltados para a educação básica e a formação de professores, sobretudo, para as regiões norte e sul do estado do Estado do Espírito Santo, norte do Rio de Janeiro, Sul da Bahia e nordeste do Estado do Minas Gerais.
Agradecemos a colaboração do Comitê Científico e dos Consultores ad hoc que dedicaram um pouco de seu tempo na avaliação dos artigos. Esperamos que os leitores aproveitem este número da Revista Eletrônica Debates em Educação Científica e Tecnológica.
Pemberitaan Dukungan Keluarga Pendiri Nahdlatul Ulama (NU) pada Prabowo-Sandi dalam Liputan6.Com (<em>Liputan6.com Reporting of NU Founders Familyâ€™s Support to Prabowo-Sandi</em>)
Authors: Zulianto Roni Ardian 
Published: December 2019

Berita yang ditayangkan oleh media massa tidak sepenuhnya sesuai dengan apa yang terjadi di lapangan, tetapi sudah mengalami pengolahan yang disesuaikan dengan ideologi media massa. Oleh sebab itu, penelitian ini ingin mengkaji teks berita dukungan keturunan keluarga pendiri NU pada capres Prabowo dan Sandi yang ditayangkan oleh Liputan6.com. Sumber data dalam penelitian ini berupa teks berita Liputan6.com pada November 2018. Metode yang digunakan adalah simak-bebas libat cakap dengan teknik klasifikasi terhadap data yang dikumpulkan. Analisis data dalam penelitian ini menggunakan metode padan-pragmatis sehingga hasil analisis data disajikan dalam uraian. Selain itu, peneliti menggunakan teori tiga dimensi Fairclough (1995) yang meliputi (1) text, (2) discourse practice, dan (3) sociocultural practice. Dari hasil penelitian ditemukan bahwa berita yang dimuat tentang dukungan tersebut tidak benar karena pada praktik sosial yang disisipkan pada beberapa kalimat oleh penulis menyatakan bahwa keturunan pendiri NU tersebut memang berkunjung, tetapi bukan untuk mendukung dalam pemilihan suara.Â The news published by mass media is not suitable with the event in the real life. However, it is processed by the ideology from mass media. That is why, this study wants to examine the critical discourse of the news about the NU founders of descendants familyâ€™s support to Prabowo-Sandi aired by the liputan6.com. The data source of this study are the news from liputan6.com in November 2018. The method used simak bebas libat cakap by using classification techniques on the data collected. While for the data analysis, the researcher uses padan-pragmatic method and the results of data analysis present in a description. The researcher uses three dimensions theories from Fairclough (1995) which are (1) text, (2) discourse practice, and (3) sociocultural practice. The result of this study showed that the news about the support of NU founder family was not true because the social practice that was inserted by writer stated that the descendants of the founder of the NU had just visited, but had not supported them in the election.
Aplikasi Berbagai Dosis dan Dua Jenis Guano pada Budidaya Tanaman Jagung Pakan (Zea mays. L) di Lahan Podsolik
Authors: Azai M. , Hafizah Nur , Mahdiannoor Mahdiannoor 
Published: December 2019

Corn feed is one animal feed that has many advantages, as corn feed is used for metabolic energy sources. Podsolic land is a land with very low nutrient value. This study aims to (i) determine the effect of various doses, and two types of guano interactions, (ii) determine the effect of various doses of guano, (iii) find out influence of two types of guano, (iv) get the best interaction, (v) get the best dose, (vi) get the best type of guano in the cultivation of corn feed in podsolic land. This research was conducted in Hawang Village, Limpasu District, Hulu Sungai Tengah Regency, from March to June 2018. They are using Group Random Design (GRD) Factorial 2 factors. The first factor is various doses of guano with five levels: d1 = 1.5 kg. plot-1, d2 = 3 kg. plot-1, d3 = 4.5 kg. plot-1, d4 = 6 kg. plot-1, d5 = 7.5 kg. plot-1. The second factor is two types of guano with two levels: g1 = bat guano, g2 = swallow guano. The results showed that the interaction between various doses and two types of guano had no effect on growth and yield, except that the effect was very significant on long cob weighted, whereas a single factor of various doses had significant and very real effect on all observation variables and the factor of two types of guano had no effect on all variables. Except for significant effect on plant height growth at the age of 56 HST.
БРОНХИАЛЬНАЯ АСТМА: ФАРМАКОГЕНЕТИЧЕСКИЕ ПОДХОДЫ К ОПТИМИЗАЦИИ ТЕРАПИИ ИНГАЛЯЦИОННЫМИ ГЛЮКОКОРТИКОСТЕРОИДАМИ
Authors: Zastrozhina A.K. , Zakharova I.N. , Sychev D.A. 
Published: December 2019

Согласно национальным и международным клиническим рекомендациям, наиболее эффективными препаратами контролирующей терапии бронхиальной астмы (БА) являются ингаляционные глюкокортикостероиды (ИГКС). Однако терапия ИГКС не всегда способствует полному контролю симптомов БА. Помимо внешних факторов, включающих низкую приверженность медицинским рекомендациям, ошибки в технике ингаляции, коморбидные состояния, а иногда и неправильную диагностику заболевания, в последнее время большое внимание уделяется фармакогенетическим механизмам снижения эффективности терапии БА. В статье представлены обзорные данные по фармакогенетическим особенностям снижения эффективности ИГКС в терапии БАAccording to national and international clinical guidelines, inhaled glucocorticosteroids (IGCS) are the most effective drugs in bronchial asthma (BA) therapy. However, IGCS do not always contribute to the full asthma control. In addition to external factors, including low adherence to medical recommendations, errors in the inhalation technique, comorbid conditions, lack of control over the effectiveness of therapeutic measures, and sometimes incorrect diagnosis, recently, much attention has been paid to pharmacogenetic mechanisms in reducing the effectiveness of asthma therapy. The article presents overview data on the pharmacogenetic features of reducing the effectiveness of inhaled corticosteroids in bronchial asthma therapy.
ДОЛГОСРОЧНАЯ ПРОФИЛАКТИКА АНГИООТЕКОВ У ПАЦИЕНТОВ С НАО
Authors: Latysheva T.V. , Latysheva E.A. , Manto I.A. 
Published: December 2019

Наследственный ангиоотек (НАО) с дефицитом С1ингибитора (С1ИНГ) представляет собой редкое заболевание, которое оказывает сильное воздействие на жизнь пациентов как физически, так и эмоционально. Непредсказуемость атак влияет на повседневную жизнь, выбор профессии, социальную активность. Кроме того, страх перед развитием отека, а также связанными с ним болью и риском смерти приводит к депрессивным расстройствам, характерным для хронических, в особенности жизнеугрожающих заболеваний. Появление современных патогенетических препаратов способно минимизировать влияние НАО и улучшить качество жизни больных. В основе терапии НАО лежат долгосрочная профилактика, краткосрочная профилактика и купирование острых атак. В данной статье речь пойдет о долгосрочной профилактике.Hereditary angioedema (HAE) due to of C1inhibitor deficiency is a rare disease, which causes a strong physical and psychological impact on patients lives. HAE affects daily life, career opportunities, and social activity. In addition, fear of the edema development, as well as the associated with it pain and risk of death leads to depressive disorders specific for chronic (especially lifethreatening) diseases. The emergence of modern pathogenetic drugs can minimize the effect of HAE and improve the patients quality of life. There are three different therapeutic strategies that are used for HAE treatment: longterm prophylaxis, shortterm and ondemand therapy for acute attacks. This article focuses on longterm prophylaxis.
PENGARUH BUDAYA ORGANISASI TERHADAP NILAI PERUSAHAAN DAN GCG SEBAGAI VARIABEL MODERATING
Authors: Dasmaran Verliani 
Published: December 2019

Abstract
The purpose of this study is To know how the influence of organizational culture on Corporate Value and To Know how Good Corporate Governance can strengthen the influence of organizational culture on corporate value, the study population is 30 companies registered in CGPI (Coorporate Governance Persepsion Index) in 2015 and the sample research into 25 companies with research methods The type of research used is associative research that is associative technique of associative research using quantitative analysis technique (statistic). To know the amount of influence between variable of writer use data analysis with help SPSS 22 : The result of research proves that there is positive influence of Organization Culture to Company Value or hypothesis (H1) accepted, and H2 rejected means Good Corporate Governance (GCG) Minimize the Effect of Organizational Culture Variables on Corporate Value. .

Keyword : organizational culture, Good Corporate Governance, Corporate Value