bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of COVID-19 on pregnancy and neonatal health: a systematic review
Authors: Mirbeyk Mona , Rezaei Nima 
Published: May 2020

Abstract
Background: In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan, China. With an incredible rate of contagion, it has reached all over the world, with more than 2 million confirmed cases at the mid of April. However, the vertical transmission of COVID-19 is uncertain. This is a systematic review of published studies concerning pregnant women with confirmed COVID-19 and their neonates.Methods: We performed a systematic search in Pubmed, Web of Sciences, Google Scholar, Scopus, and World Health Organization (WHO) COVID-19 database to find articles reporting clinical data of COVID-19-positive pregnant women and their neonates.Results: 37 articles, involving 364 pregnant women with COVID-19 and 302 neonates, were included. The vast majority of pregnant patients were in their third trimester of pregnancy, and only 45 cases were in the first or second trimester (12.4%). Most mothers described mild to moderate manifestations of COVID-19. Of 364 pregnant women, 25 were asymptomatic at the time of admission. The most common symptoms were fever (62.4%) and cough (45.3%). Two maternal deaths occurred. Some pregnant patients (12.1%) had a negative SARS‐CoV‐2 test but displayed clinical manifestations and abnormalities in computed tomography (CT) scan related to COVID‐19. Twenty‐two (6.0%) pregnant patients developed severe pneumonia. Two maternal deaths occurred from severe pneumonia and multiple organ dysfunction. Studies included a total of 302 neonates from mothers with COVID‐19. Of the studies that provided data on the timing of birth, there were 65 (23.6%) preterm neonates. One baby was born dead from a mother who also died from COVID-19. Of the babies born alive from mothers with COVID‐19, five newborns faced critical conditions, and two of which later died. A total of 219 neonates underwent nasopharyngeal specimen collection for SARS‐CoV‐2, of which 11 tested positive (5%). Seventeen studies examined samples of the placenta, breast milk, umbilical cord, and amniotic fluid, and all tested negative except one amniotic fluid sample.Conclusions: A systematic review of published studies confirm that the course of COVID-19 in pregnant women resembles that of other populations. However, there is not sufficient evidence to establish an idea that COVID-19 would not complicate pregnancy.
Structure-Based Screening of Novel Lichen Compounds for SARS Coronavirus Main protease (Mpro) and Angiotensin-Converting Enzyme 2 (ACE2) inhibitory potentials as multi-target inhibitors of COVID-19
Authors: Joshi Tanuja , Sharma Priyanka , Joshi Tushar , Pundir Hemlata , Mathpal Shalini , Chandra Subhash 
Published: May 2020

Abstract
Outbreak of SARS-CoV-2 and massing death caused by it all over world has imposed great concern on scientific community to develop potential drugs to combat with Coronaviruas disease 19 ( COVID-19 ). In this regard, lichen metabolites may offer a vast reservoir for discovery of anti-viral drug candidates. Therefore to find novel compounds against COVID-19, we created a library of 412 lichen compounds and subjected to virtual screening against two molecular targets; SARS-CoV-2 target- Main protease (Mpro) and host cell target- Angiotensin-converting enzyme 2 (ACE2). All the ligands were virtually screened, and 80 compounds were found to have better docking score with both the targets. These compounds were assessed for druglikeness analysis where 27 compounds were found to fit well for redocking studies. The results of redocking by X-Score showed that 7 out of 27 compounds were found to have high affinities with Mpro as well ACE2 which reflect that these compounds can function as dual inhibitors. Molecular docking, druglikeness, X-Score and toxicity analysis resulting seven novel lichen compounds (Orcinyllecanorate, Siphulin, Fremontol, Gyrophoric acid, Rhizocarpic acid, Ovoic acid, and Umbilicaric acid) with Mpro and ACE2 multi-target activities and they can be used as hit compounds to develop potential antiviral agents against SARS-CoV-2. These lichen compounds may be a suitable candidate for further experimental analysis.
Acute Pulmonary Embolism In Non-Hospitalized Covid-19 Patients Referred To CTPA By Emergency Department
Authors: Alban GERVAISE , Caroline BOUZAD , Evelyne PEROUX , Carole HELISSEY 
Published: May 2020

Abstract
Objectives: To evaluate the prevalence of acute pulmonary embolism (APE) in non-hospitalized COVID-19 patients referred to CT pulmonary angiography (CTPA) by Emergency Department.Methods: From March 14 to April 6, 2020, 72 non-hospitalized patients referred by Emergency Department to CTPA for COVID-19 pneumonia were retrospectively identified. Relevant clinical and laboratory data and CT scan findings were collected for each patient. CTPA scans were reviewed by two radiologists to determinate the presence or absence of APE. Clinical classification, lung involvement of COVID-19 pneumonia and CT total severity score were compared between APE group and Non-APE group.Results: APE was identified in 13 (18%) CTPA scans. The mean age and D-dimer of patients from APE group were higher in comparison with Non-APE group (74.4 vs. 59.6 years, p=0.008 and 7.29 vs. 3.29 µg/ml, p=0.011). There was no significant difference between APE and Non-APE groups concerning clinical type, COVID-19 pneumonia lung lesions (ground-glass opacity: 85 vs. 97%; consolidation: 69 vs. 68%; crazy paving: 38% vs. 37%; linear reticulation: 69 vs. 78%), CT severity score (6.3 vs. 7.1, p=0.365), quality of CTPA (1.8 vs. 2.0, p=0.518) and pleural effusion (38% vs. 19%, p=0.146).Conclusions: Non-hospitalized patients with COVID-19 pneumonia referred to CT-scan by Emergency Departments are at risk of APE. Presence of APE was not limited to severe or critical clinical type of COVID-19 pneumonia.
Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs
Authors: Anson Brandon J. , Chapman Mackenzie E. , Lendy Emma K. , Pshenychnyi Sergii , D’Aquila Richard T. , Satchell Karla J. F. , Mesecar Andrew D. 
Published: May 2020

Abstract
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to over 200,000 deaths thus far. We screened a library of approved antiviral drugs against the two SARS-CoV-2 proteases, 3C-like/main protease (3CLpro/Mpro) and papain-like protease (PLpro), which are essential for viral replication and attractive drug targets. Three HCV protease inhibitors were tested and found to inhibit 3CLpro and PLpro enzymes from Alpha-, Beta- and Gamma-coronaviruses. Anti-HIV drugs had no activity. Boceprevir and telaprevir inhibited 3CLpro, with boceprevir inhibiting eight of nine coronavirus 3CLpro enzymes tested including from SARS-CoV-2, MERS and SARS-CoV. Asunaprevir inhibited PLpro from SARS-CoV-2 and four other coronaviruses. The 1.4 Å X-ray structure of boceprevir bound to 3CLpro was determined to explain its broad-spectrum activity and guide structure-based design of inhibitors of multiple coronaviruses.Authors Brandon J. Anson, Mackenzie E. Chapman, and Emma K. Lendy contributed equally to this work.
PERAN RELIGIUSITAS DAN BATASAN WAKTU AUDIT TERHADAP EFEKTIVITAS FUNGSI INTERNAL AUDIT DI BMT KARISMA MAGELANG
Authors: Nurcahya Yulida Army , Ismawati Ema , Bharata Risma Wira 
Published: May 2020

Abstrak: Peran Religiusitas Dan Batasan Waktu Audit Terhadap Efektivitas Fungsi Internal Audit Di BMT Karisma Magelang Penelitian ini bertujuan untuk mengetahui peran religiusitas dan batasan waktu audit terhadap efektivitas fungsi audit internal di Baitul Mal Wa Tamwil (BMT) Karisma, Magelang. Terlibatnya sifat religiusitas pada sumber daya manusia di lembaga keuangan syariah, dan adanya batasan waktu yang berlaku dapat mempengaruhi efektivitas fungsi audit. Penelitian ini menggunakan metode kualitatif dengan menggunakan teknik wawancara untuk pengumpulan data. Narasumber dalam penelitian ini adalah 2 orang auditor internal yang telah menjalani profesi audit internal di BMT Karisma, Magelang. Hasil penelitian ini menunjukkan Religiusitas individu akan meningkatkan integritas dan independensi auditor yang kemudian dapat mencapai keefektifan fungsi audit internal. Adanya religiusitas di setiap individu akan mewujudkan kinerja yang penuh kehati – hatian, ketelitian, ketekunan dan terhindar dari kecurangan. Dengan terwujudnya efektivitas fungsi audit internal melalui faktor religiusitas akan menghasilkan laporan audit yang berkualitas dan dapat dipercaya, serta menjadi langkah untuk memajukan lembaga keuangan syariah. Batasan waktu sejalan dengan tingkat efektivitas fungsi audit internal. Auditor perlu menjalankan manajemen waktu di atas batasan waktu yang telah ditentukan. Sehingga, auditor dapat menuntaskan tugasnya, dan memenuhi fungsi auditor secara efektif. Kata kunci: Religiusitas, Batasan Waktu Audit, Efektivitas Fungsi Audit
The Feasibility and Utility of a Personal Health Record for Persons With Dementia and Their Family Caregivers for Web-Based Care Coordination: Mixed Methods Study
Authors: Peterson Colleen M , Mikal Jude P , McCarron Hayley R , Finlay Jessica M , Mitchell Lauren L , Gaugler Joseph E 
Published: May 2020

Background
Managing the complex and long-term care needs of persons living with Alzheimer disease and related dementias (ADRD) can adversely impact the health of informal caregivers and their care recipients. Web-based personal health records (PHRs) are one way to potentially alleviate a caregiver’s burden by simplifying ADRD health care management

Objective
This study aimed to evaluate Personal Health Record for Persons with Dementia and Their Family Caregivers (PHR-ADRD), a free web-based information exchange tool, using a multiphase mixed methods approach.

Methods
Dementia caregivers (N=34) were surveyed for their well-being and perceptions of PHR-ADRD feasibility and utility at 6 and 12 months using close- and open-ended questions as well as a semistructured interview (n=8). Exploratory analyses compared participants’ characteristics as well as PHR-ADRD use and experiences based on overall favorability status.

Results
Feasibility and utility scores decreased over time, but a subset of participants indicated that the system was helpful. Quantitative comparisons could not explain why some participants indicated favorable, neutral, or unfavorable views of the system overall or had not engaged with PHR-ADRD. Qualitative findings suggested that technology literacy and primary care provider buy-in were barriers. Both qualitative and qualitative findings indicated that time constraints to learn and use the system affected most participants.

Conclusions
Development and dissemination of PHRs for family caregivers of persons with ADRD should aim to make systems user-friendly for persons with limited time and technological literacy. Establishing health care provider buy-in may be essential to the future success of any PHR system.
Review of Cervical Cancer Preventive and Screening Strategies in India
Authors: Meena Devi , Chand Subhash , Kumar Deovrat 
Published: May 2020

Cervical cancer (CC) rapidly spread in the women. CC is the cancer which start from the cervix this is the 1st stage and 3rd most common type cancer in women’s worldwide. Continuously, Human papillomavirus (HPV) infection is the higher&strongest epidemiologic risk factor for CC.HPV-16 and HPV-18, these are type virus with high-risk HPV types. But at present many types of techniques available as – Pap smear test, Colposcopy, HPV virus test/detection, Visual inspection of cervix with 5% acetic acid, and Visual inspection of cervix with Lugol’s Iodine.The majority of diagnosis with CC will be analyzed more than 13000 and rate of death 4000 with women in United States and it also deadline disease in India. It is one of the cancer which is preventable. This article studied with in PubMed and Google scholar, studies about cervical cancer from Wikipedia and you-tube also. And it is only meta-analysis or multi-institutional, review article and research studies were considered for analysis of cervical cancer. The most important risk factor is determined with human beings Human papillomavirus (HPV) which traditional in worldwide. This is the type of cancer which is screening and detect in the early stage by the screening methods. In this article, abstracted published studies about to year between during 1995-2018 which has been carried out in worldwide on CC with significance on screening test methods. Basically, Pap smear is the method of screening for cytology but now a day many studies have been accomplish to investigate different methods as well as visual inspection method.
Keywords: Cervical Cancer screening, HPV, Screening methods, Pap Smear test, India United State.
Lead Exposure Causes Alteration of Haematological Indices in Adult Female Wistar Rats
Authors: I Adeyomoye O , A Adewumi N 
Published: May 2020

Objective: Lead is a heavy metal widely distributed in the environment. It is known to be a toxicant and has no biological function. Humans are constantly exposed to lead from many sources and its effects on the haematological indices have not been fully elucidated. Therefore, this study aimed to investigate the changes in haematological profile of adult female Wistar rats exposed to lead.
Design: Forty-five female Wistar rats with average weight of 150 ± 20g were randomly distributed into 3 groups of 15 rats each. Group 1 served as the control and was exposed to water only, group 2 was exposed to lead acetate (500mg/L) while group 3 was exposed to lead acetate (1000mg/L). The rats were exposed to lead for 52 days. On the 26th, 39th and 52nd days of exposure, five rats (n=5) were sacrificed from each group after mild anaesthesia and their blood samples were taken into EDTA bottles for haematological analysis using blood auto-analyzer. Results were analyzed using two-way ANOVA and p<0.05 were considered statistically significant.
Main outcome measure: There was significant increase (p<0.05) in white blood cell and lymphocyte counts in 500mg/L and 1000mg/L lead exposed groups when compared to the control. There was significant decrease (p<0.05) in monocyte and granulocyte counts in 500mg/L and 1000mg/L lead exposed groups when compared to control group. Platelet counts significantly increased (p<0.05) in 500mg/L and 1000mg/L lead exposed groups when compared to control group.
Conclusion: In conclusion, exposure to lead at 500 and 1000mg/L increased white blood cells, lymphocyte and platelet counts while it decreased monocyte and granulocyte counts in adult female Wistar rats. Therefore, lead at the exposed levels caused some alterations in the haematological parametersin adult female Wistar rats.
Quality Assessment of Antibiotic Oral Drug Formulations Marketed In Katsina State, Nigeria
Authors: Lawal Mukhtar Gambo , Mukhtar Muhammad Dauda , Magashi Abdulkadir Magaji 
Published: May 2020

There are increasing reports on the high incidence of substandard drugs, especially in developing countries.Pharmaceutical products have been reported to contain either no, low, or excessive amounts of the active pharmaceutical ingredient (API). Inview of the above, 112 samples of six different antibiotic oral drug formulations were evaluated for chemical quality by assessing the presence and the percentage content of the stated active pharmaceutical ingredients using validated HPLC assay as described in the official monograph of the British and United Stated pharmacopoeia. The result indicates that 43 (38.4%) had active ingredients outside the set pharmacopoeial limit and therefore were non-compliant to the BP and the USP specifications for percentage content. Ampiclox and Cotrimoxazole had the highest proportion of samples with active ingredient outside the pharmacopoeial limit, and in three samples (one Augmentin and two Ampiclox), no active ingredient was detected. The presence of API lower than the claimed content declared on the packaging was the primary cause of non-compliance. The potential implications of the use of substandard drugs are treatment failure and the development of drug-resistance.
Antiinflammatory Activity of Pagoda Flower (Clerodendrum Paniculatum L.) Ethanol Extract Using Paw Edema Method
Authors: Hafiz Ihsanul , Ginting Mandike 
Published: May 2020

Objectives: The purpose of this study was to determine antiinflammatory activity of pagoda flower (Clerodendrum paniculatum L.) ethanolic extract
Design: This study uses an experimental laboratory design. This research uses paw edema method by inducing carrageenin in the legs of male white rats as an induction of inflammation.
Interventions: The sample used was pagoda flower ethanol extract in various dosages of 25, 50 and 100 mg / kg. As a comparison, acetosal dose 33 mg / kg was used. Na CMC suspension was used as a negative control.
Main outcome measure: The results in this study are the difference in the volume of edema volume from rat feet per unit time. The measurement of the rat's leg volume was measured at 30, 60, 120, 180, 240 and 300 minutes.
Conclusion: Pagoda flower ethanol extract does not have good anti-inflammatory activity. there were no significant differences between groups except at dose 100 and positive control at minute 300 of negative control.
GALVANI, VOLTA E OS EXPERIMENTOS CRUCIAIS: A EMBLEMÁTICA CONTROVÉRSIA DA ELETRICIDADE ANIMAL
Authors: Raicik Anabel Cardoso 
Published: May 2020

A controvérsia entre Galvani e Volta, acerca da eletricidade animal, pode ser considerada uma das maiores da história da ciência. Ao longo dessa querela, os pressupostos teóricos de cada um dialogaram proficuamente com inúmeros experimentos desenvolvidos. Os experimentos, carregados de teoria, fizeram do sapo o melhor amigo ou inimigo, por tanto ‘sofrer’) de ambos; satisfazia os desejos de cada um, voltando-se tanto à eletrobiologia quanto a eletrofísica. Resgatando sucintamente este embate, esse artigo discute alguns experimentos desenvolvidos por esses dois estudiosos, que ilustram a concepção steinleana de experimentação exploratória, ressalta alguns aspectos relativos à Natureza da Ciência nesse percurso, discorre em que sentido alguns experimentos podem, em princípio, serem considerados cruciais na controvérsia e evidencia implicações para o ensino de ciências.
LICENCIATURAS EM CIÊNCIAS DA NATUREZA DO INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DE RONDÔNIA (IFRO): O SABER O QUE ENSINAR
Authors: Rohers Penha Maranei , Pontin Darsie Marta Maria 
Published: May 2020

Este artigo resulta de uma pesquisa realizada nas licenciaturas em Ciências da Natureza do Instituto Federal de Educação, Ciência e Tecnologia de Rondônia, por meio de análise documental e questionário misto, e integrou parte de uma pesquisa de doutorado, que objetivou compreender os processos de implantação de licenciaturas no IFRO e a formação inicial de professores das referidas licenciaturas. A análise de quatro Projetos Pedagógicos de Cursos, vigentes entre 2010/1 e 2015/2, evidenciou significativa diferença quantitativa de oferta de disciplinas relacionada ao saber o que ensinar e ausência de disciplinas vinculadas a saberes regionais. A pesquisa também demonstrou que 72,7% dos Docentes Formadores afirmaram que as licenciaturas em Ciências Biológicas, Física e Química garantem a aprendizagem do saber o que ensinar; contudo, apontaram a necessidade de mais discussões e ações coletivas. Todos os Professores Egressos declararam que o saber o que ensinar foi assegurado durante seus processos de formação inicial.
PENERAPAN METODE CONTRAST STRETCHING, HISTOGRAM EQUALIZATION DAN ADAPTIVE HISTOGRAM EQUALIZATION UNTUK MENINGKATKAN KUALITAS CITRA MEDIS MRI
Authors: Wijaya Kusuma I Wayan Angga , Kusumadewi Afriliana 
Published: May 2020

Citra medis adalah suatu pola atau gambar dua dimensi bagian dalam tubuh manusia yang digunakan oleh ahli kesehatan untuk mendeteksi dan menganalisa penyakit pasien. Pada bidang radiologi citra yang sering digunakan saat ini adalah citra Magnetic resonance Imaging (MRI). Keunggulan citra MRI adalah kemampuan menampilkan detail anatomi secara jelas dalam berbagai potongan (multiplanar) tanpa mengubah posisi pasien. Citra MRI ini akan digunakan oleh dokter ataupun peneliti untuk melakukan analisis ada tidaknya suatu tumor, kanker, atau kelainan pada pasien. Penelitian ini mengusulkan metode Contrast Stretching, Histogram Equalization dan Adaptive Histogram Equalization untuk meningkatkan kualitas citra medis. Batasan masalah penelitian ini adalah citra medis MRI yang digunakan sebagai obyek penelitian adalah citra medis MRI Otak baik yang normal atau yang mengalami lesi (gangguan). Dari hasil kualitas citra dan analisa kuantitatif menunjukkan bahwa metode contrast stretching menghasilkan hasil kualitas citra MRI jauh lebih baik dibandingkan dengan metosde histogram equalization, dan adaptive histogram equalization. Nilai MSE yang paling rendah adalah pada metode contrast stretching yaitu 0,00346. Sedangkan nilai MSE yang paling besar dihasilkan oleh metode histogram equalization. Kualitas citra dengan metode contrast stretching menghasilkan nilai PSNR yang paling besar yaitu 22,0677. Ini menandakan bahwa kualitas citra dari metode contrast stretching jauh lebih baik dibandingkan metode histogram equalization, dan adaptive histogram equalization.
CLUSTERING K-MEANS PADA DATA EKSPOR (STUDI KASUS: PT. GAIKINDO)
Authors: Afifi Wakhid , Nastiti Dhiya'an Ramadhanty , Aini Qurrotul 
Published: May 2020

PT Gaikindo adalah sebuah perusahaan otomotif dan produsen kendaraan bermotor yang mengirimkan produknya hingga ke luar negeri. Berdasarkan data ekspor mobil pada PT Gaikindo, terdapat banyak mobil dengan jumlah ekspor yang bervariasi. Oleh karena itu, PT. Gaikindo membutuhkan data mobil mana yang terlaris dan yang tidak laris untuk mengatur volume pengiriman mobil ke luar negeri. Penelitian ini menggunakan metode clustering dengan algoritma k-means. Metode ini mengelompokkan data dengan cara memasukkan data brand dan tipe mobil yang dikirim pada setiap negara. Hasil penelitian ini menunjukkan terdapat 3 cluster yang terbentuk dengan kategori sangat diminati, cukup diminati, dan sedikit diminati.
SIMULASI DATABASE BEBAN KERJA DOSEN PERGURUAN TINGGI MENGGUNAKAN DIMENSIONAL MODELING
Authors: Anisah Anisah , Yurindra Yurindra , Japriadi Yohanes Setiawan , Andrika Yuyi , Pradana Harizki Arie 
Published: May 2020

Data warehouse sudah banyak digunakan untuk membantu eksekutif dalam pengambilan sebuah keputusan, diantaranya bidang kesehatan, bidang perhotelan, dan tidak ketinggalan di bidang pendidikan. Akan tetapi, belum banyak yang menggunakan data warehouse khususnya untuk keperluan Beban Kerja Dosen (BKD). Penelitian sebelumnya ada yang melakukan penelitian mengenai BKD, tetapi sebatas perancangan untuk database operasional. Beban kerja dosen haruslah dilakukan evaluasi agar dosen yang ada di perguruan tinggi merupakan dosen yang profesional yang senantiasa menjunjung tinggi pelaksanaan Tri Dharma Perguruan Tinggi. Masalah yang dihadapi saat ini, untuk mendukung proses evaluasi beban kerja dosen dan pengambilan keputusan yang tepat oleh para pemangku kepentingan perguruan tinggi tersebut, belum adanya suatu database beban kerja dosen yang terintegrasi dan terpusat yang bisa diakses oleh pemangku kepentingan perguruan tinggi untuk memperoleh informasi stategis mengenai beban kerja dosen suatu perguruan tinggi secara lengkap, cepat dan akurat. Adapun tujuan dari penelitian ini adalah merancang data warehouse yang dapat membantu para pemangku kepentingan perguruan tinggi dalam memperoleh informasi stategis mengenai beban kerja dosen tersebut. Metode penelitian yang digunakan pada tahap analisis dan perancangan data warehouse menggunakan Four Step Methodology kimball. Database yang dihasilkan akan dilakukan simulasi dengan menggunakan interface PhpMyadmin untuk kemudian dilakukan evaluasi mengenai rancangan database yang dihasilkan untuk mengetahui sampai sejauh mana kemampuan database data warehouse beban kerja dosen ini bisa menghasilkan informasi strategis beban kerja dosen yang dibutuhkan oleh perguruan tinggi.