bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma
Authors: An Shejuan , Camarillo Jeannie , Huang Tina , Li Daphne , Morris Juliette , Zoltek Madeline , Qi Jin , Behbahani Mandana , Kelleher Neil , Nazarian Javad , Thomas Paul , Saratsis Amanda Muhs 
Published: November 2020

Abstract
Background: Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone post-translational modification (PTM) states and transcription. Here, we employed quantitative proteomic analysis to elucidate the impact of the H3.3K27M mutation, as well as radiation and bromodomain inhibition (BRDi) with JQ1, on DIPG PTM profiles.Methods: We performed targeted mass spectrometry on H3.3K27M mutant and wild-type tissues (n=12) and cell lines (n=7).Results: We found 29.2% and 26.4% of total H3.3K27 peptides were H3.3K27M in mutant DIPG tumor cell lines and tissue specimens, respectively. Significant differences in modification states were observed in H3.3K27M specimens, including at H3K27, H3K36, and H4K16. In addition, H3.3K27me1 and H4K16ac were the most significantly distinct modifications in H3.3K27M mutant tumors, relative to wild-type. Further, H3.3K36me2 was the most abundant co-occurring modification on the H3.3K27M mutant peptide in DIPG tissue, while H4K16ac was the most acetylated residue. Radiation treatment caused changes in PTM abundance in vitro, including increased H3K9me3. JQ1 treatment resulted in increased mono- and di-methylation of H3.1K27, H3.3K27, H3.3K36 and H4K20 in vitro. Conclusion: Taken together, our findings provide insight into the effects of the H3K27M mutation on histone modification states and response to treatment, and suggest that H3K36me2 and H4K16ac may represent unique tumor epigenetic signatures for targeted DIPG therapy.
An Assessment of Band Keratopathy Depth With Anterior Segment Optical Coherence Tomography
Authors: Song Hee-Jun , Rand Gabriel M. , Chuck Roy S. , Kwon Ji-won 
Published: November 2020

Abstract
Background: To describe the anterior segment optical coherence tomography (AS-OCT) findings in a series of patients with band keratopathy (BK) and discuss its possible clinical utility. Methods: A retrospective review of 31 eyes from 31 consecutive patients with BK from November 2013 to October 2018. Lesion depth and central corneal thickness (CCT) were outputted from AS-OCT (RS-3000 Advance, NAVIS-EX 1.5.5 Nidek CO LTD, Japan). Results: There were 20 cases of ocular trauma, 3 cases of retinal detachment, 2 cases of glaucoma, 2 cases of uveitis, 1 case of Coats’ disease, 1 case of complicated cataract surgery, 1 case of non-clearing vitreous hemorrhage, and 1 case of unknown etiology. Mean duration of the opacity per patient history was 22.4±11.3 (range 3-40) years. 26 eyes were no light perception (NLP), 3 eyes were light perception (LP) and 2 eyes were hand motion (HM). The calcium band as seen on AS-OCT corresponded to a hyperflective layer with posterior shadowing. The median depth of calcium was 100 µm (range 55-320) and the median CCT was 623 µm (range 534-785). The calcium depth was strongly correlated with the duration of the opacity per patient history (r=0.68, p<0.001). Conclusions: AS-OCT may be utilized to assess BK depth. This depth has a wide distribution that is positively correlated with the duration of the opacity per patient history. Future studies will be required to measure BK depth across patients with less severe vision loss, test the consistency of AS-OCT measurements across different instruments, and confirm its clinical utility.
Role of temporal discounting in a conditional cash transfer (CCT) intervention to improve engagement in the prevention of mother-to-child transmission (PMTCT) cascade
Authors: Saleska Jessica Londeree , Turner Abigail Norris , Gallo Maria F. , Shoben Abigail , Kawende Bienvenu , Ravelomanana Noro Lantoniaina Rosa , Thirumurthy Harsha , Yotebieng Marcel 
Published: November 2020

Abstract
Background: Temporal discounting, the tendency of individuals to discount future costs and benefits relative to the present, is often associated with greater engagement in risky behaviors. Incentives such as conditional cash transfers (CCTs) have the potential to counter the effects of high discount rates on health behaviors. Methods: With data from a randomized trial of a CCT intervention among 434 HIV-positive pregnant women in the Democratic Republic of Congo, we used binomial models to assess interactions between discount rates (measured using a delay-discounting task) and the intervention. The analysis focused on two outcomes: 1) retention in HIV care, and 2) uptake of prevention of mother-to-child transmission (PMTCT) services. Results: The effect of high discount rates on retention was small, and we did not observe evidence of interaction between high discount rates and CCT on retention. However, our findings suggest that CCT may mitigate the negative effect of high discount rates on uptake of PMTCT services (interaction contrast (IC): 0.18, 95% CI: -0.09, 0.44). Conclusions: Our findings provide evidence to support the continued use of small, frequent incentives, to motivate improved uptake of PMTCT services, especially among women exhibiting high rates of temporal discounting.
Social Listening – Revealing Parkinson’s Disease over Day and Night
Authors: Zhang Hui , Meng Fanwen , Li Xingyu , Ning Yali , Cai Meng 
Published: November 2020

Abstract
Background: Nocturnal symptoms in Parkinson’s disease are often treated after management of daytime manifestations. In order to better understand the unmet needs of nocturnal symptoms management, we analyzed the characteristics and burden of nocturnal symptoms from patients’ perspectives and explored their changes over time. Overall symptoms (occurring at day or night) were collected to compare whether the unmet needs related to nocturnal symptoms and to overall symptoms are different.Methods: We used a Social Listening big-data technique to analyze large amounts of Parkinson’s disease symptoms in dialogues available from social media platforms in 2016 to 2018. These symptoms were classified as either overall symptoms or nocturnal symptoms. We used share of voice (SOV) of symptoms as a proportion of total dialogues per year to reflect the characteristics of symptoms. Negative sentiment score of symptoms was analyzed to find out their related burden. Results: We found the SOV for overall motor symptoms was 79% and had not increased between 2016 and 2018 (79%, p = 0.5). The SOV for non-motor symptoms was 69% and had grown by 7% in 2018 (p < 0.01). The SOV for motor complications was 9% and had increased by 6% in 2018 (p < 0.01). The SOV of motor symptoms was larger than non-motor symptoms and motor complications (p < 0.01). The SOV of non-motor symptoms was larger than motor complications (p < 0.01). For nocturnal symptoms, 45% of the analyzed PD population reported nocturnal symptoms in 2018, growing by 6% (p < 0.01). The SOV for nocturnal-occurring motor symptoms was higher than most non-motor symptoms. However, non-motor symptoms had the higher increases and evoked higher negative sentiment regardless of whether they occurred during the day or night. For symptoms that can occur at either day or night, each nocturnal symptom was rated with a higher negative sentiment score than the same symptom during the day.Conclusions: The growing SOV and the greater negative sentiment of nocturnal symptoms suggest management of nocturnal symptoms is an unmet need of patients. A greater emphasis on detecting and treating nocturnal symptoms with 24-hour care is encouraged.
Bile acid, glucose, lipid profile, and liver enzyme changes in pre-diabetics: 1-year data after sleeve gastrectomy
Authors: Mak Tsz Kin , Huang Shifang , Guan Bingsheng , Au Hoyin , Chong Tsz Hong , Peng Juzheng , Chen Fazhi , Liang Chuqiao , Lai Wanjing , Ho LongLam , Wang Cunchuan , yang jingge 
Published: November 2020

Abstract
Background: Few articles have studied pre-diabetes after sleeve gastrectomy. Bile acid, and lipid level remains inconsistent in post-bariatric patients. To explore bile acid and glucose, lipid, and liver enzyme changes in different diabetic status underwent sleeve gastrectomy. To discuss the impact of bariatric surgery and its potential benefits to pre-diabetics Methods: 202 overweight and obese patients underwent bariatric surgery between January 2016 and October 2018 in our hospital were retrospectively reviewed. They were divided into Pre-diabetes (n=32), Non-diabetes (n=144), and Diabetes (n=26) and analyzed respectively. Data of glucose and lipid were collected from medical records from baseline and each follow-up visit. Result: Significant improvement in body weight, glucose and lipid level, and liver enzyme at P≤0.05 in prediabetics were found throughout first year post-op. Improvement of glycemic control was first seen in a month post op, followed by persistent improvement in the next 12 months. Total bile acid (TBA) decreased, associated with ALT improvement, in pre-diabetes 1-year post-surgery. There was no significant differences in HbA1c, glucose, and triglycerides (TG) between Pre-diabetics and T2DM nor between prediabetics and non-diabetics at 12 months post-surgery. Conclusion: LSG is highly effective in interfering glucose and lipid level as well as total bile acid of prediabetics in the first year post operation. Thus, LSG is indeed an alternative for overweight and obese pre-diabetics
Joint Optic Disc and Cup Segmentation Based on Densely Connected Depthwise Separable Convolution Deep Network
Authors: Liu Bingyan , Pan Daru , Song Hui 
Published: November 2020

Abstract
Background: Glaucoma is an eye disease that causes vision loss and even blindness. The cup to disc ratio (CDR) is an important indicator for glaucoma screening and diagnosis. Accurate segmentation for the optic disc and cup helps obtain CDR. Although many deep learning-based methods have been proposed to segment the disc and cup for fundus image, achieving highly accurate segmentation performance is still a great challenge due to the heavy overlap between the optic disc and cup.Methods: In this paper, we propose a two-stage method where the optic disc is firstly located and then the optic disc and cup are segmented jointly according to the interesting areas. Also, we consider the joint optic disc and cup segmentation task as a multi-category semantic segmentation task for which a deep learning-based model named DDSC-Net (densely connected depthwise separable convolution network) is proposed. Specifically, we employ depthwise separable convolutional layer and image pyramid input to form a deeper and wider networkto improve segmentation performance. Finally, we evaluate our method on two publicly available datasets, Drishti-GS and REFUGE dataset.Results: The experiment results show that the proposed method outperforms state-of-the-art methods, such as pOSAL, GL-Net, M-Net and Stack-U-Net in terms of disc coefficients, with the scores of 0.9780 (optic disc) and 0.9123 (optic cup) on the DRISHTI-GS dataset, and the scores of 0.9601 (optic disc) and 0.8903 (optic cup) on the REFUGE dataset. Particularly, in the more challenging optic cup segmentation task, our method outperforms GL-Net by 0.7 % in terms of disc coefficients on the Drishti-GS dataset and outperforms pOSAL by 0.79 %on the REFUGE dataset, respectively.Conclusions: The promising segmentation performances reveal that our method has the potential in assisting the screening and diagnosis of glaucoma.
Effect of Opium Consumption on Cardiovascular Diseases – A cross- sectional study based on data of Rafsanjan cohort study
Authors: Khalili Parvin , Ayoobi Fatemeh , Mohamadi Maryam , Jamalizadeh Ahmad , Vecchia Carlo La , Esmaeili-Nadimi Ali 
Published: November 2020

Abstract
Background: There are differences of opinion about the beneficial or detrimental effects of opium consumption on cardiovascular diseases (CVDs). So, we aimed to study the association between opium use and CVDs. Methods: We used data obtained from the Rafsanjan Cohort Study (RCS), as a part of the prospective epidemiological research studies in IrAN (PERSIAN), with detailed, validated data on opium consumption and some other exposures. A total of 10,000 adults were enrolled in the study. Logistic regression models were used to assess the possible relationships of opium consumption with the prevalence of ischemic heart diseases (IHD) and myocardial infarction (MI). Results: In this study, 9990 participants in the baseline phase of the Rafsanjan adult cohort study were included according to their completed questionnaire. Among all participants, 870 and 296 individuals were found to suffer from IHD and MI, respectively. Opium consumption was found to be relatively high in the RCS participants, especially in men (men= 2150 and women= 228). Opium use was associated with a higher odds of IHD and MI, with the adjusted odds ratios (95% CI) of 1.51 (1.22-1.86) and 1.79 (1.31-2.45), respectively. Also, dose-response increases were observed with the highest odds ratios in the 4th quartile for MI and IHD (p-values for trend < 0.001). Increased odds were observed for the two main methods of opium consumption, i.e. oral and smoking, but oral administration had higher odds ratio.Conclusions: Opium consumption is associated with the increased odds of both IHD and MI diseases.
Inguinal hernias in patients on continuous ambulatory peritoneal dialysis: is tension-free mesh repair feasible?
Authors: Chi Qiyu , Shi Zheng , Zhang Zhibo , Lin Chunzhong , Liu Guozhong , Weng Shangeng 
Published: November 2020

Abstract
Background:Continuous ambulatory peritoneal dialysis (CAPD), which often causes a common complication such as abdominal wall hernia, is a prevalent alternative therapy for end-stage renal failure patients. However, relevant studies are somewhat rare, and the peritoneal dialysis (PD) protocol during the perioperative period is still controversial. The aim of this study was to evaluate the effectiveness and perioperative management of tension-free mesh repair for inguinal hernias in CAPD patients.Methods:Between January 2013 and December 2019, 18 CAPD patients with 20 inguinal hernias who underwent tension-free mesh repair were retrospectively analyzed. Data on demographics, perioperative features, the perioperative dialysis protocol and surgical complications were collected and assessed.Results:All hernias were diagnosed after the start of CAPD, and the median duration from PD onset to hernia formation was 16 months (2-61 months). All patients underwent successful tension-free mesh repair, including 17 Lichtenstein and 3 anterior Kugel procedures. The median operation time was 62.5 min, and the median postoperative hospital stay was 3 days. Fifteen patients received low-exchange volumes and high-frequency exchanges from 1-3 days after surgery for 2 weeks with gradual resumption of the original CAPD regimen within 4 weeks. Complications included seroma (n = 2) and hematoma (n = 1). No wound or mesh infection or recurrence occurred during the follow-up period.Conclusions:Tension-free mesh repair is safe and feasible for inguinal hernias in CAPD patients, The Lichtenstein mesh repair should be the first choice, and anterior Kugel repair may be considered an effective procedure. Bridging hemodialysis seems unnecessary except for emergency surgery.
Analysis of treatment outcomes for destructive pulmonary tuberculosis in patients with multiple drug resistance of M. tuberculosis
Authors: Sheyfer Yu. A. , Gelberg I. S. 
Published: November 2020

The objective of the study: to analyze treatment outcomes in patients with pulmonary destructive MDR tuberculosis who completed the intensive phase of treatment and had healed or persisting cavities.Subjects and methods. Treatment outcomes were retrospectively analyzed in 191 patients suffering from destructive pulmonary MDR tuberculosis who underwent the intensive phase of chemotherapy in in-patient settings in 2009-2012 and 2013-2015 (treated by different regime ns); in each of those cohorts, groups were formed depending on persistence/healing of destruction (cavities) during the intensive phase of chemotherapy: (CV-) ‒ the destruction healed, (CV+) – the destruction persisted.Results. In 24 months, treatment was found to be effective only in 19/68 (27.9%) in the (CV+) group versus 31/40 (77.5%) in the (CV-) group, p < 0.05 (cohort 2009-2012); 17/42 (40.5%) versus 29/41 (70.7%), respectively, p < 0.05 (2013-2015 cohort). Within 48 months, treatment outcomes were as follows: clinical cure in the (CV+) group was 38.2% (26/68 people), and in the (CV-) group – 72.7% (29/40 people), p < 0.05 (2009- 2012) and 23/42 (54.7%) and 33/41 (80.5%), respectively, p < 0.05 (2013-2015 cohort).Conclusion. Considering the above, when assessing treatment in the intensive phase of chemotherapy in destructive pulmonary tuberculosis patients, it is necessary to take into account the rate of cavity healing but not being limited to sputum conversion. Patients with persisting cavities should not be transferred to the continuation phase, the surgery or collapse treatment should be considered for such patients.
Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis
Authors: Lapshina I. S. , Salikhov B. U. , Myakisheva T. V. , Kostromtsov S. V. , Paramonov A. V. , Аndreev V. A. 
Published: November 2020

The objective: to determine factors influencing treatment efficacy in patients with multiple (MDR) and extensive (XDR) drug resistant tuberculosis. Subjects and methods. The medical files of 107 tuberculosis patients (men – 75, women – 32) were analyzed, 17 of them were HIV positive. Those 107 patients were registered for treatment as per chemotherapy (CT) regimens IV-V in 2017 in Kaluga Region. 99 (92.5%) patients suffered from tuberculosis with lung tissue destruction. 60.7% (65 patients) had MDR, while 20.8% (22 patients) had XDR. Only 58.2% of patients had MDR TB confirmed by polymerase chain reaction before treatment start.Results. In 24 months, the effective course of treatment was registered in 64/107 (59.8%). The highest level of effective treatment was expectedly registered among new cases – 21/30 (70%); and the lowest level was among patients starting chemotherapy again after treatment interruption – 4/10 (40%), p > 0.05. Among 64 patients with effective treatment course, 25 (39.1%) had surgery and 39 (60.9%) had chemotherapy only. Surgical activity among the cohort of 2017 made 26/107 (24.3%). The effective treatment outcome was achieved in 8 (47%) out of 17 patients with TB/HIV co-infection, and among HIV negative patients it was reached in 56/90 (62.2%), p > 0,05.
Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study
Authors: Vizel A. A. , Culver D. A. , Vizel I. Yu. , Shakirova G. R. , Bakunina E. A. 
Published: November 2020

The objective:to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment.Subjects and methods.The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).Conclusion.The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.
Energy Optimisation of Research Buildings in Vienna with a Photovoltaic Façade.
Authors: BIEDROŃSKA Joanna 
Published: November 2020

Abstract
Research consisting in the analysis, definition of parameters of a high degree of energy efficiency with a guaranteed share of renewable energy is of particular importance in the implementation of the concept of sustainable development. In Vienna, there have been built buildings whose construction and operation inscribe into an extensive research programme that includes an energy management strategy according to the latest standards developed for energy-efficient construction. These buildings, which are represented by research and educational institutions, are a kind of research field for new technologies and solutions to optimise energy consumption. In architectural terms, the implementation of photovoltaic façades signals the high technological level of prototype solutions. The Author’s research methodology was based on the analysis of data characterizing new and modernized buildings, carried out on the basis of current internet sources, literature data and local visions during her study trip to Vienna. The aim of the paper is to present the energy concept of buildings, used to optimize energy acquisition and consumption, as a signpost for the application of guidelines and standards in possible Polish solutions.
The Potential Clinical Value of Curcumin and its Derivatives in Colorectal Cancer
Authors: Yao Zhaoying , Le Thi Ha , Du Qianming , Mu Huiwen , Liu Chao , Zhu Yubing 
Published: November 2020

Background:
Curcumin, a naturally occurring polyphenol, possesses pleiotropic pharmacologic
properties, including anti-inflammatory and anti-oxidant activities. Epidemiological evidence suggests that
curcumin intake is associated with a reduced risk of Colorectal Cancer (CRC), highlighting the enormous
potential of this botanical agent in the prevention and treatment of CRC.

Objective:
We summarize the anticancer activity of curcumin and its derivatives in CRC.

Methods:
We conducted a literature review on the therapeutic effects of curcumin and its derivatives in CRC.

Results:
In this review, a summary of the activities of curcumin in the treatment of CRC regarding its
bioavailability, anticancer activity, modes of action, curcumin delivery systems have been provided based on the
researches from preclinical experiments. Also, we discuss the therapeutic effects of curcumin derivatives in CRC.
The human clinical trials that used curcumin or curcumin derivatives for the treatment of CRC are also
highlighted here.

Conclusion:
Curcumin possesses great potential as a chemopreventive agent in CRC. Moreover, emerging
evidence reveals that it can be an effective adjuvant to CRC therapy. To date, few studies have explored the anticolon
cancer activity of curcumin formulation and curcumin derivatives in vivo; therefore, more works are
needed to confirm their effectiveness. In clinical trials, curcumin treatment protocols (formulation, dose, and
duration) vary among studies. However, these trials consistently point out that the compound is well-tolerated
and safe, albeit with little consensus on its therapeutic efficacy.
Do velho exército profissional ao cidadão soldado
Authors: Peregrino Humberto 
Published: November 2020

Enquanto predominou, sólida e suficiente, a burguesia rural, o Exércitopermaneceu em posição secundária, como organização militar. É verdade que‘'a formação brasileira foi tão complexa, em seu processo, que admitiu — conformeaguda observação de Nelson Werneck Sodré — a discordância, emverdade berrante, da elaboração, dentro de um estado em que dominavauma classe, de uma fôrça militar que não era, de forma absoluta, representaçãofiel dessa classe” ; muito ao contrário, nas fileiras, na sua intimidadeorgânica, ocorrera “a infiltração e até a dominação, de elementos que eram,pela ordem natural das coisas, adversos à burguesia rural.”