bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Critical Role of Tumor Size in Predicting Prognosis for T1 Colon Cancer
Authors: Dai Weixing , Mo Shaobo , Xiang Wenqiang , Han Lingyu , Li Qingguo , Wang Renjie , Xu Ye , Cai Guoxiang 
Published: November 2019

Abstract

Background
The role of horizontal growth index of tumor size in survival prediction is still underappreciated in colon cancer because of the identification of vertical infiltration index reflected by T stage. We sought to reveal the impact of T stage on the prognostic and predictive value of tumor size in colon cancer.

Materials and Methods
Data of patients with stage I–III colon cancer were extracted from Surveillance, Epidemiology, and End Results Program (SEER) and Fudan University Shanghai Cancer Center (FUSCC) databases. Harrell's concordance index (c-index) and time-dependent receiver operating characteristic curve (ROC) were used to analyze the discriminative ability of prognostic factors.

Results
Stratified analyses based on T stage found that the increase of T stage significantly and negatively repressed the effect of tumor size on death and recurrence risk. In addition, tumor size showed the greatest hazard ratio of cancer-specific death and relapse in T1 colon cancer. Even more importantly, the discriminatory ability of tumor size outperformed any other widely accepted prognostic clinical features in predicting cancer-specific survival (SEER: c-index 0.637, area under the ROC [AUC] 0.649; FUSCC: c-index 0.673, AUC 0.686) and disease-free survival (FUSCC: c-index 0.645, AUC 0.656) in T1 stage colon cancer.

Conclusion
Tumor size is a critical clinical factor with considerable prognostic and predictive value for T1 colon cancer, and it should be selectively incorporated into the current staging system to facilitate prediction of death and recurrence risk.
KÜÇÜK HÜCRELİ DIŞI AKCİĞER KANSERLİ HASTALARDA TÜMÖR HİSTOPATOLOJİSİNİN LOKAL VE UZAK NÜKSE ETKİLERİ
Authors: AKIN Süleyman Emre , DURAN Ferdane Melike 
Published: November 2019

Amaç: Akciğer kanseri tüm dünyada kansere bağlı ölümlerde
kadınlarda ve erkeklerde birinci sırada yer almaktadır. Sağkalımı etkileyen en
önemli belirleyici TNM evreleme sistemi ve en etkili tedavi cerrahidir. Bu
çalışmada komplet rezeksiyon uyguladığımız küçük hücreli dışı akciğer kanserli
(KHDAK) hastalarda tümör patolojik özelliklerinin lokal ve uzak nükse
etkilerini araştırmayı amaçladık.

Yöntem: 2008-2012 yılları arasında kliniğimizde KHDAK nedeniyle
komplet cerrahi rezeksiyon gerçekleştirilen 57 hasta retrospektif olarak
değerlendirildi. Hastalara ait histolojik tip, diferansiasyon, nekroz varlığı,
visseral-paryetal plevra tutulumu, N1-N2 tutulumu, patolojik evre gibi
verilerle lokal ve uzak nüks gelişimi, nüks yeri ilişkisi ve bunların 3 yıllık
sağkalıma etkileri araştırıldı.

Bulgular: Tümör histopatolojik özellikleri ile lokal ve uzak nüks arasında yapılan
kıyaslamada elde edilen değerler istatistiksel olarak anlamlı bulunmadı. 3 yıllık sağkalımı etkileyen parametrelerden
diferansiasyon (p=0.012), patolojik evre (p=0.027), paryetal plevra tutulumu
(p=0.016), uzak nüks gelişimi (p=0.014), uzak nüks yeri (p=0.011) ve
postoperatif uzak nüks zamanı (p=0.048) arasındaki kıyaslamada istatistiksel
olarak anlamlı değerler elde ettik.

Sonuç:
KHDAK’li hastalarda tümör patolojik özellikleri lokal ve uzak nüks üzerinde etkili bir parametre olarak
gözükmemektedir.
The relationship between sexuality and temperament in patients with epilepsy
Authors: Sosnina V. G. , Saraykin D. M. , Lipatova L. V. 
Published: November 2019

Aim: to study the relationship between sexuality and temperament in patients with epilepsy.Materials and methods. The study included 102 participants: 52 patients with epilepsy and 50 healthy individuals aged from 19 to 45 years. The psychological examination was based on the I-structural test of Ammon (ISTA), the Structure of temperament questionnaire (STQ) of Rusalov, and a clinical interview.Results. Using the correlation analysis we were able to reveal 9 correlations between the types of sexuality and the temperament characteristics in patients with epilepsy; in subjects of the control group – 4 correlations were found. Thus, in patients with epilepsy, constructive sexuality positively correlated with plasticity, social erginess, and pace, whereas in healthy subjects – with social erginess. In patients with epilepsy, destructive sexuality positively correlated with plasticity, social erginess, and social plasticity; in healthy subjects, destructive sexuality negatively correlated with social erginess. In patients with epilepsy, deficient sexuality negatively correlated with pace, plasticity, and social erginess, whereas in healthy subjects – with plasticity and social plasticity.Conclusion. The study shows that the sexuality in patients with epilepsy is more deterministic than that in the comparison group. In addition, all types of sexuality in these patients correlate with plasticity and social erginess, which suggests that patients with epilepsy can be satisfied with sexual relations, show flexibility and strive for diversity while being flexible and socially active. These correlations can be read vice versa, i.e., striving for diversity and social activity in patients with epilepsy is accompanied by satisfaction with their sexual relations and inclination to experiment.
TRENDS IN THE MODERNIZATION OF THE CRIMINAL LAW RESPONSE TO DRUG CRIME
Authors: Dziadkouski Andrei 
Published: November 2019

The paper deals with the problem of countering the illicit drug trafficking, psychotropic substances, their precursors and analogues in the Eurasian Economic Union countries. The authors, basing on the statistical data analysis, demonstrated an increase in the number of drug addicts; it is shown that drug addiction is a global problem nowadays. The constant increase of registered criminal acts related to drugs and their cross-border nature make it necessary to develop cooperation in combating the illicit distribution of drugs, harmonizing and unifying legal norms in this area, especially within the framework of the Eurasian Economic Union. A comparative legal analysis of the criminal law governing liability for drug trafficking in the EAEU countries shows the diversity of legislative structures in the key elements of the crimes under consideration. The issues of personal non-medical use liability, the subject of crimes, the criminalization of individual acts related to drug trafficking, should be the subject of discussion on developing a unified approach of criminal law to counter the analyzed crimes in the EAEU countries.
DEVELOPMENT OF UNIFIED PROCEDURES FOR FINANCIAL INSTITUTIONS IN ORDER TO PREVENT MONEY LAUNDERING AND TERRORISM FINANCING
Authors: Kalinina Suzanna 
Published: November 2019

The relevance of the topic is confirmed by the changes taking place in the financial monitoring system: the expansion of the financial monitoring range of procedures complication´s supervisory bodies aimed at countering money laundering and financing of terrorism, the creation of specialized international and European requirements, which causes changes in the legal regulation of public relations in this area, both at the level of the Estonian Republic, and at international level. Taking into account these changes, financial institutions are a subject to significant legal risks. The purpose of this topic is to improve the financial institution risk management system, in the field of anti-money laundering and countering financing of terrorism. The theoretical and methodological basis of the study are the provisions and conclusions regarding anti-money laundering and countering financing of terrorism risk management issues contained in the research works of different Estonian and Russian authors; as well as the author analysed anti money laundering and counter terrorism financing legal acts and revealed the main recommendations to financial institutions for preventing money laundering and terrorism financing. The author analyses reasons, which affect licenses withdrawal due to breach of money laundering. The nature of the tasks and the system approach to their solution determined the use of the following research methods in the research: analysis and synthesis, grouping and classification, scientific generalization, expert assessments and graphical analysis.
Earthquake Rupture Scaling Relations for Mainland China
Authors: Cheng Jia , Rong Yufang , Magistrale Harold , Chen Guihua , Xu Xiwei 
Published: November 2019

AbstractMagnitude‐rupture scaling relations describe how the length, width, and area of fault rupture vary with earthquake magnitude. These parameters are required in seismic hazard models to fit the models’ earthquakes onto faults and to define the site‐rupture distances needed in ground‐motion prediction equations. We collected the magnitude and rupture parameters of 91 earthquakes in Mainland China and nearby regions to study magnitude‐rupture scaling relations. We find no systematic deviations for the subsurface rupture length (RLD) obtained from different methods versus earthquake magnitude. We performed regressions of RLD versus magnitude and versus rupture width using general orthogonal regression. Then, we derived the relations between rupture area and magnitude. Our relations are not statistically different from the results derived by others using global datasets, if the parameters of the five pre‐1900 great earthquakes in eastern China are not used. However, if the five earthquakes are used, the magnitude‐rupture length scaling relation for large strike‐slip earthquakes in eastern China gives shorter rupture lengths than earthquakes in western China and other plate boundary regions in the world.
Consejos de Papá
Authors: Goyeneche Fredy Eduardo 
Published: November 2019

Camina por el lado opuesto de las angustias, desplaza tus pasos un tanto al centro pero mantén el equilibrio, que el lado izquierdo cercano al corazón sepa que hace tu mano derecha de acciones diversas. No te distraigas con mariposas amarillas, ni escuches la última campanada ni el tercer canto de gallos de falsas madrugadas. Los ladrones de destinos acecharán para la primera dentellada cuando te muestren el oropel de las fantasías de mala ley y peores premoniciones de recuerdos vacíos...
INVESTIGATING THE USE OF CIGARETTE, ALCOHOL, AND DRUG IN STUDENTS AND FACTORS AFFECTING IT
Authors: Rahmati Robab , Amirfakhraei Azita , Karemafshar Eshrat 
Published: November 2019

Purpose: Increasing the use of cigarettes, drug and alcohol in adolescents have nowadays become a serious challenge in communities. Thus, the present study was conducted to investigate the use of drugs, cigarettes, and alcohol and factors affecting adolescents.
Methodology: The research method was a cross-sectional survey study. The research population included all of the second-grade high school students in the Tehran province cities. Using random cluster sampling method, 448 of them were selected and responded to the test questions.
Result: The research results showed that boys used hubble-bubble (0.88), alcohol (0.51), cigarette (0.39), psychotropic pills (21) and girls used hubble-bubble (0.79), alcohol (0.29), and psychotropic pills (0.28) and cigarettes (0.17). The rate of using all drugs was higher in boys than that of girls. The use of hubble-bubble and alcohol had the highest rate and the use of heavier drugs was less prevalent. However, as the use of lighter drugs predisposed one person to use other drugs, taking preventive measures in schools and at an early age was essential.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of Investigating the Use of Cigarette, Alcohol, and Drug in Students and Factors Affecting it is presented in a comprehensive and complete manner.
ASSESSMENT MODEL OF QUALITY AND DEMAND FOR EDUCATIONAL SERVICES CONSIDERING THE CONSUMERS’ OPINION
Authors: A. G. Tyurikov , A. N. Zubets , P. V. Razov , A. N. Amerslanova , N. V. Savchenko 
Published: November 2019

Purpose: The purpose of the article is to develop an integrative, structural and functional, indicative, aggregating, algorithmic, the multi-criteria model for assessing the quality and demand for educational services of higher education considering the consumers’ opinion.
Methodology: The leading research method of the indicated problem was the assessment of various aspects of educational relations in the process of complex diagnostics of the studied phenomena, which includes: preliminary system model of research, interpretation and operationalization of the basic concepts included in it; relevant means of fixation of primary characteristics; the order of data collection; algorithm of analysis and data processing in order to obtain a rating assessment proposed as a mechanism for assessing the quality and demand for educational services with the participation of consumers.
Result: The authors substantiate the inclusion in the system of indicators of both objective characteristics: the professional status of graduates of higher educational institutions (the share of employed, the level of wages, the area of employment), the status of educational programs (social and professional accreditation), and their subjective characteristics, expressed in: the formation of professional competencies of graduates (including hard skills and soft skills), which together characterize their professional subjectivity. The materials of the article are of practical value for government agencies, heads of educational institutions, rating agencies, representatives of organizations-employers, applicants, their parents, and students.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of Assessment model of quality and demand for educational services considering the consumers’ opinion is presented in a comprehensive and complete manner.
Karakterisasi Bakteri Endofit Kitinolitik sebagai Agens Biokontrol Patogen Ganoderma boninense pada Kelapa Sawit [Characterization of Chitinolytic Endophyte Bacteria as Biocontrol Agents of Ganoderma boninense Pathogen on Oil Palm]
Authors: Rahma Rahma , Kuswinanti Tutik , Rosmana Ade 
Published: November 2019

<p>Basal stem rot caused by <em>Ganoderma boninense</em> is one crucial disease in oil palm. The used of chitinolytic bacteria is one part of biological control to suppress <em>G. boninense</em>. This study aimed to isolate and characterize chitinolytic bacteria associated with roots of oil palm which have the potential as agents biocontrol against the pathogens of <em>G. boninense</em>, the caused of basal stem rot disease of oil palm. The study was conducted in North Luwu, East Luwu, and Makassar Districts from January to September 2017. The research was done in four stages that consist of isolation of endophytic bacterial, testing chitinolytic activity, testing antagonistic and biochemical identification. The results showed that from 14 bacterial isolates obtained, two of them had chitinolytic activity with index of 2,35 and 3,37 respectively. Both of these bacteria can inhibit <em>G. boninense</em> on solid medium by 24,9% and 69,4% respectively and on the liquid medium by 47,5% and 68,5% respectively five days after inoculation. Based on biochemical characterization, these bacteria have similarities with <em>Bacillus</em> sp, and <em>Serratia</em> sp. To be concluded, <em>Serratia</em>sp. is a potential medium to be for controling basal stem rot disease on oil palm.</p><p align="center"><strong>ABSTRAK</strong></p>Busuk pangkal batang yang disebabkan oleh cendawan <em>Ganoderma</em> <em>boninense</em> merupakan salah satu penyakit penting pada kelapa sawit. Pemanfaatan bakteri kitinolitik merupakan salah satu bagian pengendalian hayati untuk mengontrol <em>G. boninense. </em>Penelitian ini bertujuan untuk mengisolasi dan mengkarakterisasi bakteri kitinolitik yang berasosiasi dengan akar tanaman kelapa sawit yang berpotensi sebagai agens biokontrol terhadap <em>G. boninense, </em>penyebab penyakit busuk pangkal batang kelapa sawit. Penelitian dilaksanakan di Kabupaten Luwu Utara, Luwu Timur, dan Makassar sejak bulan Januari sampai September 2017. Penelitian ini terdiri atas empat tahap, yaitu isolasi bakteri endofit, uji aktivitas kitinolitik, uji antagonis dan identifikasi secara biokimia. Hasil penelitian diperoleh 14 isolat bakteri dimana dua bakteri diantaranya memiliki aktivitas kitinolitik dengan indeks masing masing 2,35 dan 3,37. Kedua bakteri tersebut dapat menghambat <em>G. boninense</em> pada medium padat masing masing 24,9% dan 69,4% serta pada medium cair masing masing 47,5% dan 68,5% lima hari setelah inokulasi. Berdasarkan karakterisasi secara biokimia, bakteri tersebut memiliki kemiripan dengan <em>Bacillus </em>sp, dan <em>Serratia </em>sp. Hasil penelitian menunjukkan bahwa <em>Serratia </em>sp. berpotensi dalam mengendalikan penyakit busuk pangkal batang pada kelapa sawit.<em></em><p> </p><p> </p>
Pertumbuhan dan Produktivitas Beberapa Varietas Ubi Kayu dengan Tingkat Pupuk yang Berbeda di Lahan Tegakan Jati Muda
Authors: Wahyuningsih Sri , Sutrisno Sutrisno 
Published: November 2019

<p>Penelitian dilaksanakan pada lahan jati umur 2 tahun di Perum Perhutani KPH Blora, Desa Bogem, Kecamatan Japah. Percobaan menggunakan rancangan petak terbagi, diulang empat kali. Petak utama adalah lima varietas ubi kayu yaitu: Adira 4, Malang 4, Litbang UK 2, Cecek Ijo, dan UJ 5. Anak petak adalah tiga dosis pemupukan yaitu: a) 100 kg Urea + 125 kg SP36 + 75 KCl (input rendah), b) 125 kg Urea + 150 kg SP36 + 100 KCl, (input sedang), c) 200 kg Urea + 200 kg SP36 + 125 kg KCl + 5000 kg pupuk kandang (input tinggi). Hasil penelitian menunjukkan tidak terdapat pengaruh interaksi antara varietas dengan pemberian pupuk terhadap hasil ubi kayu. Hasil ubi kayu dengan input rendah, sedang, dan tinggi berturut-turut adalah 25,38 t, 27,29 t, dan 25,81 t/ha. Rata-rata hasil ubi tertinggi diperoleh Varietas Malang 4 (32,01 t/ha), kemudian diikuti Adira 4, Cecek ijo, UJ 5, dan Litbang UK 2, masing-masing 28,22 t, 27,64 t, 23,43 t dan 21,50 t/ha. Varietas Malang 4 memberikan hasil tertinggi dengan perlakuan input sedang (33,00 t/ha). <br /><br /></p>
Produktivitas Beberapa Genotipe Kacang Tanah dan Ketahanannya terhadap Penyakit Layu Bakteri Ralstonia Solanacearum
Authors: Purnomo Joko , Nugrahaeni Novita , Baliadi Yuliantoro 
Published: November 2019

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Di Indonesia, kacang tanah ditanam pada beragam tipe lahan yaitu lahan sawah pada musim kemarau, sawah tadah hujan pada awal atau pertengahan musim kemarau, dan lahan kering pada awal musim hujan. Pada lahan-lahan tersebut, penyakit layu bakteri menjadi kendala biotik utama dalam budi daya kacang tanah sehingga produktivitasnya rendah. Penelitian ini bertujuan untuk mengevaluasi tingkat hasil galur-galur harapan kacang tanah dan ketahanannya terhadap serangan penyakit layu bakteri </span><span>Ralstonia solanacearum. </span><span>Penelitian dilaksanakan pada sembilan lokasi di enam daerah sentra produksi kacang tanah pada musim kemarau dan musim hujan mulai tahun 2014 hingga 2016, menggunakan rancangan acak kelompok, tiga ulangan. Perlakuan adalah 14 galur harapan dan dua varietas pembanding. Uji ketahanan terhadap serangan penyakit layu bakteri dilaksanakan di rumah kaca dan di Pati, Jepara, dan Wonogiri yang endemik layu bakteri. Hasil penelitian menunjukkan bahwa Mutan 6 (tipe Spanish) dan BM/ IC//IC-172-1 (tipe Valencia) mempunyai potensi hasil tertinggi di sembilan lokasi, masing-masing 3,48 t/ha dan 3,44 t/ha polong kering. Hasil polong genotipe Mutan 6 unggul di dua lokasi, dan BM/IC//IC-172-1 unggul di tiga lokasi. Mutan 3, Mutan 5, BM/IC-154-2, Bm/IC/ /IC-170-8, dan BM/IC//IC-164-1 memberikan hasil polong tertinggi di satu lokasi, dan genotipe lainnya tidak unggul di semua lokasi uji. Genotipe Mutan 6 mempunyai daya adaptasi umum yang baik dan mampu beradaptasi di banyak ragam lingkungan. BM/IC//IC-172-1 mempunyai daya adaptasi yang baik di sembilan lokasi. Hampir semua genotipe yang diuji menunjukkan status rentan hingga agak rentan, sedangkan BM/IC-154-2 dan BM/ IC//IC-172-1 mempunyai status agak tahan ketika ditanam di tiga daerah endemik penyakit layu bakteri </span><span>R. solanacearum</span><span>. </span></p></div></div></div>
Isotopic tracing with carbon-13 in primary hepatocytes
Authors: Overmyer Katherine A 
Published: November 2019

Abstract
Isotopic labeling is commonly applied for investigating intracellular metabolism. The general workflow is to first introduce isotopically-labeled metabolites into the culture medium, then at defined time points wash and harvest cells, process samples for metabolomics analysis, and analyze the samples for isotopic enrichment in specified metabolite pools. Here we apply this technique to primary hepatocytes from mice. We introduce either 13C5 glutamine or 13C6 glucose at the typical media concentrations, 1:1 replacing the 12C version with 13C version. Cells are harvested at 0 and 30 min after isotope introduction, metabolites are extracted and then analyzed by GC-MS and LC-MS. The resulting data are used to compare relative 13C isotopic labeling in metabolites between different genetic mutants. This strategy is not suitable for directly quantifying metabolic flux (i.e., Metabolic flux analysis), but is useful for describing relative metabolic flux between two models. The expected time to complete is ~3-5 days.
The effect of rhizosphere soil on the flavonoid metabolism in the roots of Tetrastigma hemsleyanum
Authors: Xiang Taihe , Tong Xiaxiu , Li Jiangshan , Xu Zhengxian , Zhou Xinyuan , Bao Shuying , Li Chongshun 
Published: November 2019

Abstract
Background: Tetrastigma hemsleyanum (T. hemsleyanum) is a precious and rare traditional Chinese medicinal plant. Flavonoid is its main medicinal ingredient. Wild T. hemsleyanum (W-TH) growing in Zhejiang Province, China is recognized as a medicinal material of “San Ye Qing” Dao-di herbs. The different origins and thus the contents of medicinal ingredients are the key criteria used to determine whether the medicinal materials are authentic Dao-di herbs. However, it is less known how the eco-environments of its specific producing area, especially microbial community in rhizosphere soil, affect the content of medicinal ingredients in “San Ye Qing”. In the present study, we determined the content of total flavonoids and the enzymatic activity of phenylalanine ammonia-lyase (PAL) in the roots of W-TH and artificially cultivated T. hemsleyanum (C-TH), as well as the nutrient compositions and metagenome in rhizosphere soil. The effects of the rhizosphere soil on the flavonoid metabolism in T. hemsleyanum were evaluated. Results: The contents of total flavonoids and the PAL activity were higher in W-TH root than in C-TH root. The contents of both available phosphorus and available potassium were higher in the rhizosphere soil of W-TH than in that of C-TH, while the contents of nitrogen and organic matter in the rhizosphere root of C-TH were higher than that of W-TH. Compared with the rhizosphere of C-TH, the abundances of genera Enterobacter, Serratia, Raoultella, Kluyvera, Comamonas, Acinetobacte, and Arthrobacter, and the pathways related to nitrogen metabolism, inositol phosphate metabolism, phosphinate metabolism, and phosphotransferase system in the rhizosphere of W-TH were significantly different. There existed differences in phenylpropanoid biosynthesis and phenylalanine metabolism in the rhizospheres of W-TH and C-TH. Conclusions: The contents of nitrogen and available phosphorus in the rhizosphere soil affect diversity abundance, nitrogen metabolism, phosphorus metabolism, and phenylalanine (Phe) anabolism of rhizosphere microorganisms. They may further affect Phe content and PAL activity for the synthesis of flavonoids in the root of T. hemsleyanum.