bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on thermomechanical coupling characteristics of embedded sensor lithium batteries under low‐temperature environment
Authors: Chen Xian‐Tao , Wang Chun‐Xiao , Sun Qiang , Wang Hai‐bin , Xie Song , He Yuan‐Hua 
Published: November 2019

AbstractAircraft usually undergoes a low temperature during flight. It is crucial to understand the strain generation mechanism within lithium‐ion batteries in low temperature to prevent electrode rupture caused by uneven strain of the cell. As such, LFP pouch cell was chosen as experimental objects and the sensors were embedded inside the battery to get the internal parameters directly. Battery cycle experiments were conducted in a 2 m × 2 m × 2 m cabin in, respectively, 25°C, 10°C, −10°C, −20°C ambient temperatures with high C rates of 3C during the charge‐discharge process, which is to simulate the aircraft flying process in low temperatures at different altitudes. Parameters such as voltage, internal temperature, and strain were measured. The results revealed the significant impact on thermomechanical coupling characteristics of LFP battery caused by low temperature. As the ambient temperature decreases, the maximum strain increases. The strain is positively correlated with the temperature of the battery, and as the ambient temperature decreases, battery temperature would have more effects on strain. Besides, it was also found that in a low‐temperature environment, the heat generated by the battery itself is beneficial to its performance recovery.
Species differences in immune‐mediated CNS tissue injury and repair: A (neuro)inflammatory topic
Authors: Healy Luke M. , Yaqubi Moein , Ludwin Samuel , Antel Jack P. 
Published: November 2019

AbstractCells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) molecules, in neural development and rare genetic disorders (e.g., colony stimulating factor 1 receptor [CSF1R] deficiency). Genome wide association studies suggest a comparable role of the immune system in humans. Although the CNS can be the target of primary autoimmune disorders, no current experimental model captures all of the features of the most common human disorder placed in this category, multiple sclerosis (MS). Such features include spontaneous onset, environmental contributions, and a recurrent/progressive disease course in a genetically predisposed host. Numerous therapeutic interventions related to antigen and cytokine specific therapies have demonstrated effectiveness in experimental autoimmune encephalomyelitis (EAE), the animal model used to define principles underlying immune‐mediated mechanisms in MS. Despite the similarities in the two diseases, most treatments used to ameliorate EAE have failed to translate to the human disease. As directly demonstrated in animal models and implicated by correlative studies in humans, adaptive and innate immune constituents within the systemic compartment and resident in the CNS contribute to the disease course of neurodegenerative and neurobehavioral disorders. The expanding knowledge of the molecular properties of glial cells provides increasing insights into species related variables. These variables affect glial bidirectional interactions with the immune system as well as their own production of “immune molecules” that mediate tissue injury and repair.
Spatiotemporal analysis of event‐related fMRI to reveal cognitive states
Authors: Fincham Jon M. , Lee Hee Seung , Anderson John R. 
Published: November 2019

AbstractCognitive science has a rich history of developing theories of processing that characterize the mental steps involved in performance of many tasks. Recent work in neuroimaging and machine learning has greatly improved our ability to link cognitive processes with what is happening in the brain. This article analyzes a hidden semi‐Markov model‐multivoxel pattern‐analysis (HSMM‐MVPA) methodology that we have developed for inferring the sequence of brain states one traverses in the performance of a cognitive task. The method is applied to a functional magnetic resonance imaging (fMRI) experiment where task boundaries are known that should separate states. The method is able to accurately identify those boundaries. Then, applying the method to synthetic data, we explore more fully those factors that influence performance of the method: signal‐to‐noise ratio, numbers of states, state sojourn times, and numbers of underlying experimental conditions. The results indicate the types of experimental tasks where applications of the HSMM‐MVPA method are likely to yield accurate and insightful results.
Context of maternal intrusiveness during infancy and associations with preschool executive function
Authors: Broomell Alleyne P.R. , Smith Cynthia L. , Calkins Susan D. , Bell Martha Ann 
Published: November 2019

AbstractThe relation between maternal behavior and neurocognitive development is complex and may depend on the task context. We examined 5‐month‐old infant frontal electroencephalogram (EEG), maternal intrusiveness (MI) evaluated during two play contexts at 5 and 10 months, and a battery of executive function (EF) tasks completed at 48 months to evaluate if MI during infancy and infant neural function interacted to predict later cognition. Infant frontal EEG was a predictor of 4‐year EF. MI during structured play at both 5 and 10 months predicted preschool EF, and MI during unstructured did not have a main effect on EF but showed a potential moderating effect of infant EEG on later EF. The pattern changed between ages, with MI during structured play at 5 months showing a positive association with age 4 EF, whereas MI during structured play at 10 months had a negative association with age 4 EF. We demonstrate differences in the context of maternal behavior used to predict childhood EF, highlighting the importance of considering parenting context in EF development.Highlights

The context of maternal behavior is important for its longitudinal implications on cognitive development.
Level of maternal intrusiveness and infant frontal electroencephalogram (EEG) power predicted preschool executive function in different patterns depending on mother–infant interaction context.
The associations between maternal intrusiveness and executive function depended on the task context, age at interaction, and neural function of infants.
How does monetary policy respond to the dynamics of the shadow banking sector?
Authors: Agnello Luca , Castro Vitor , Jawadi Fredj , Sousa Ricardo M. 
Published: November 2019

AbstractWe investigate the response of the central bank to the change in size of nonbank financial intermediaries. Using quarterly data for the United States over the period 1946:Q1‐2016Q4, we find that when faced with an increase in the asset growth of the securities' brokers and dealers and the shadow banking sector, the monetary authority reacts by raising the short‐term nominal interest rate. This response is stronger in the case of sharp variation in the size of the balance sheet of nonbank financial intermediaries. From a policy perspective, our study suggests that an extended version of the original Taylor rule—embedding both price stability and financial stability concerns—provides a good characterization of the monetary policy reaction function.
Effect of a structured educational package on women's sexual function during pregnancy
Authors: Mahnaz Esmaeili , Nasim Bahrami , Sonia Oveisi 
Published: November 2019

AbstractObjectiveTo explore the effect of a structured educational package based on ADDIE (analysis, design, development, implementation, evaluation) to reduce sexual dysfunction during pregnancy.MethodsA randomized controlled trial study among pregnant women attending prenatal clinics in Tehran, Iran, from October 2017 to September 2018. The implementation group received the structured educational package; the control group received training on breastfeeding and normal delivery. The outcome measure was changes in total and domain scores of the Female Sexual Function Index (FSFI) questionnaire before and after the intervention; the groups were compared by repeated‐measures analysis of variance (ANOVA).ResultsOverall, 70 women completed the study: 36 in the intervention group and 34 in the control group. Sexual desire (P=0.019), arousal (P=0.001), lubrication (P=0.001), orgasm (P=0.001), satisfaction (P=0.007), and total FSFI score (P<0.001) improved significantly in the intervention group as compared with the control group. However, there was no difference in sexual pain after the intervention (P=0.78).ConclusionThe structured educational package was found to reduce sexual dysfunction by improving knowledge of and attitudes toward the physical and psychologic changes that occur during pregnancy among Iranian women attending routine prenatal care visits as part of a healthcare center's program.Iranian Registry of Clinical Trials: IRCT20140907019077N14.
The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone
Authors: Jo Stephanie Y , Domowicz Miriam S , Henry Judith G , Schwartz Nancy B 
Published: November 2019

ABSTRACTOsteoarthritis and osteoporosis are widely prevalent and have far‐reaching public health implications. There is increasing evidence that epigenetics, in particular, histone 3 lysine 79 methyltransferase DOT1L, plays an important role in the cartilage and bone biology. In this study, we evaluated the role of Dot1l in the articular cartilage, growth plate, and trabecular bone utilizing conditional KO mouse models. We generated chondrocyte‐specific constitutive and inducible conditional Dot1l KO mouse lines using Col2a1‐Cre and Acan‐CreER systems. Prenatal deletion of Dot1l in mouse chondrocytes led to perinatal mortality, accelerated ossification, and dysregulation of Col10a1 expression. Postnatal deletion of Dot1l in mouse chondrocytes resulted in trabecular bone loss decreased extracellular matrix production, and disruption of the growth plate. In addition, pharmacological inhibition of DOT1L in a progeria mouse model partially rescued the abnormal osseous phenotype. In conclusion, Dot1l is important in maintaining the growth plate, extracellular matrix production, and trabecular bone. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
The Polycomb Protein Bmi1 Plays a Crucial Role in the Prevention of 1,25(OH)2D Deficiency-Induced Bone Loss
Authors: Sun Haijian , Qiao Wanxin , Cui Min , Yang Cuicui , Wang Rong , Goltzman David , Jin Jianliang , Miao Dengshun 
Published: November 2019

ABSTRACT
We analyzed the skeletal phenotypes of heterozygous null Cyp27b1 (Cyp27b1+/−) mice and their wild-type (WT) littermates to determine whether haploinsufficiency of Cyp27b1 accelerated bone loss, and to examine potential mechanisms of such loss. We found that serum 1,25-dihydroxyvitamin D [1,25(OH)2D] levels were significantly decreased in aging Cyp27b1+/− mice, which displayed an osteoporotic phenotype. This was accompanied by a reduction of expression of the B lymphoma Moloney murine leukemia virus (Mo-MLV) insertion region 1 (Bmi1) at both gene and protein levels. Using chromatin immunoprecipitation (ChIP)-PCR, electrophoretic mobility shift assay (EMSA) and a luciferase reporter assay, we then showed that 1,25(OH)2D3 upregulated Bmi1 expression at a transcriptional level via the vitamin D receptor (VDR). To determine whether Bmi1 overexpression in mesenchymal stem cells (MSCs) could correct bone loss induced by 1,25(OH)2D deficiency, we overexpressed Bmi1 in MSCs using Prx1-driven Bmi1 transgenic mice (Bmi1Tg) mice. We then compared the bone phenotypes of Bmi1Tg mice on a Cyp27b1+/− background, with those of Cyp27b1+/− mice and with those of WT mice, all at 8 months of age. We found that overexpression of Bmi1 in MSCs corrected the bone phenotype of Cyp27b1+/− mice by increasing osteoblastic bone formation, reducing osteoclastic bone resorption, increasing bone volume, and increasing bone mineral density. Bmi1 overexpression in MSCs also corrected 1,25(OH)2D deficiency-induced oxidative stress and DNA damage, and cellular senescence of Cyp27b1+/− mice by reducing levels of reactive oxygen species (ROS), elevating serum total superoxide dismutase levels, reducing the percentage of γH2A.X, p16, IL-1β, and TNF-α–positive cells and decreasing γH2A.X, p16, p19, p53, p21, IL-1β, and IL-6 expression levels. Furthermore, 1,25(OH)2D stimulated the osteogenic differentiation of MSCs, both ex vivo and in vitro, from WT mice but not from Bmi1−/− mice and 1,25(OH)2D administration in vivo increased osteoblastic bone formation in WT, but not in Bmi1 −/− mice. Our results indicate that Bmi1, a key downstream target of 1,25(OH)2D, plays a crucial role in preventing bone loss induced by 1,25(OH)2D deficiency. © 2019 American Society for Bone and Mineral Research.
Estradiol‐17β inhibits homocysteine mediated damage by promoting H2S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells
Authors: Zhang Dandan , Hong Xiuqin , Wang Jia , Jiang Yu , Zhang Ying , Chen Jian , Niu Xiaona 
Published: November 2019

AbstractAssociated with reduced hydrogen sulfide (H2S) production in Hcy metabolic disorders, Plasma Hcy accumulation can bring about vascular dysfunction. Nevertheless, recently proposed therapies for vascular damage by estrogen could contribute to promoting endogenous hydrogen sulfide production. This study explores whether estrogen can come into play in protection in hyperhomocysteinemia and hypertensive patients at a population level, and then analyses the specific mechanism of estrogen protection in homocysteine (Hcy)‐treated human umbilical vein endothelial cells (HUVECs) at the foundational level. A case‐control study, conducted on 1277 female hypertension and non‐hypertensive patients from Hunan Provincial People's Hospital, showed that the Hcy concentration of hypertensive patients emerged higher than that of healthy controls (P < .001), and that of estrogen was the reverse (P < .001). Estrogen had a negative correlation with systolic blood pressure and plasma Hcy concentration. HUVECs were treated with estrogen and Hcy in the basic experimental part, and 17β‐estradiol (E2β) stimulated proliferation and inhibited damage in Hcy‐treated umbilical vein endothelial cells. Treatment with Hcy dampens the expression of cystathionine β‐synthase (CBS) and cystathionine γ‐lyase (CSE) then cuts down H2S production in cultured HUVECs, however, E2β reverses this process. To sum up, we have demonstrated a significant correlation between estrogen, Hcy concentration and systolic blood pressure reduction, which is bound up with Hcy metabolism and endogenous hydrogen sulfide production. The role of E2β was further strengthened by CBS and the CSE inhibitor through overthrowing the change in hydrogen sulfide of Hcy‐treated HUVECs.
A Review of Cannabis and Interactions With Anticoagulant and Antiplatelet Agents
Authors: Greger Jessica , Bates Vernice , Mechtler Laszlo , Gengo Fran 
Published: November 2019

AbstractLegalization of medical cannabis has occurred in 33 states and the District of Columbia, and recreational use has increased exponentially since 2013. As a result, it is important to understand how cannabis interacts with other drugs and has potential risks for patients on concomitant medications. Components of medical cannabis can inhibit or compete for several cytochrome P450 (CYP) hepatic isoenzymes, UDP‐glucuronosyltransferases, and P‐glycoprotein. These enzymes and transporters are involved in the metabolism and absorption of numerous medications, including anticoagulants (ACs) and antiplatelet agents (APs), potentially causing harmful drug‐drug interactions. ACs and/or APs are often prescribed to high‐risk patients with cardiac conditions, a history of myocardial infarction, or stroke. Cannabis may cause these medications to be less efficacious and put patients at risk for recurrent cardiovascular and cerebrovascular events. Several case reports show cannabis may inhibit the metabolism of warfarin because of CYP2C9 interactions, resulting in increased plasma concentrations, increased international normalized ratio, and risk of bleeding. Cannabidiol inhibits CYP2C19, an isoenzyme responsible for the transformation of clopidogrel to its active thiol metabolite. This interaction could lead to subtherapeutic levels of active metabolite and possibly increased stroke risk. Within this review, a total of 665 articles were screened from PubMed and EMBASE. Four case reports, 1 in vitro study, and 1 pharmacokinetic article were found to be of relevance. This review serves to examine reported and potential cannabis interactions with APs/ACs to help inform patients and health care providers of possible risks and knowledge gaps.
Transdifferentiation and mesenchymal‐to‐epithelial transition during regeneration in Demospongiae (Porifera)
Authors: Ereskovsky Alexander V. , Tokina Daria B. , Saidov Danial M. , Baghdiguian Stephen , Le Goff Emilie , Lavrov Andrey I. 
Published: November 2019

AbstractOrigin and early evolution of regeneration mechanisms remain among the most pressing questions in animal regeneration biology. Porifera have exceptional regenerative capacities and, as early Metazoan lineage, are a promising model for studying evolutionary aspects of regeneration. Here, we focus on reparative regeneration of the body wall in the Mediterranean demosponge Aplysina cavernicola. The epithelialization of the wound surface is completed within 2 days, and the wound is completely healed within 2 weeks. The regeneration is accompanied with the formation of a mass of undifferentiated cells (blastema), which consists of archaeocytes, dedifferentiated choanocytes, anucleated amoebocytes, and differentiated spherulous cells. The main mechanisms of A. cavernicola regeneration are cell dedifferentiation with active migration and subsequent redifferentiation or transdifferentiation of polypotent cells through the mesenchymal‐to‐epithelial transformation. The main cell sources of the regeneration are archaeocytes and choanocytes. At early stages of the regeneration, the blastema almost devoid of cell proliferation, but after 24 hr postoperation (hpo) and up to 72 hpo numerous DNA‐synthesizing cells appear there. In contrast to intact tissues, where vast majority of DNA‐synthesizing cells are choanocytes, all 5‐ethynyl‐2′‐deoxyuridine‐labeled cells in the blastema are mesohyl cells. Intact tissues, distant from the wound, retains intact level of cell proliferation during whole regeneration process. For the first time, the apoptosis was studied during the regeneration of sponges. Two waves of apoptosis were detected during A. cavernicola regeneration: The first wave at 6–12 hpo and the second wave at 48–72 hpo.
MnSb2O6‐chitosan nanocomposite: An efficient catalyst for the synthesis of coumarins via Pechmann reaction
Authors: Bahramnezhad Baharak , Ghazanfari Dadkhoda , Sheikhhosseini Enayatollah , Akhgar Mohammad Reza , Ahmadi Sayed Ali 
Published: November 2019

AbstractIn this work, MnSb2O6‐chitosan nanocomposites were synthesized and have been employed in Pechmann condensation for the synthesis of coumarin derivatives. MnSb2O6‐chitosan nanocomposites were characterized by Fourier transform infrared (FTIR), X‐ray powder diffraction (XRD), scanning electron microscope (SEM), and energy‐dispersive X‐ray spectroscopy (EDX) techniques. The particles of MnSb2O6‐chitosan have uniform spheres with sizes that are less than 100 nm. Simplicity, easy work‐up, and short reaction times are advantages of this reaction. Also, we evaluated the antibacterial activity for some of the products, and the result showed significant pharmaceutical activities as antibacterial reagents against Staphylococcus aureus and Escherichia coli.
Den Site Selection by the Florida Spotted Skunk
Authors: Harris Stephen N. , Doonan Terry J. , Ragheb Erin L. Hewett , Jachowski David S. 
Published: November 2019

ABSTRACTThe eastern spotted skunk (Spilogale putorius) is a species of conservation concern in much of its range and has experienced a decline since the early to mid‐1990s. But the subspecies that inhabits peninsular Florida, the Florida spotted skunk (S. p. ambarvalis), might still be abundant and is an important nest predator of the endangered Florida grasshopper sparrow (Ammodramus savannarum floridanus). To gain insight on this little‐studied subspecies and inform potential management strategies, we conducted a resource selection study on the Florida spotted skunk. We examined 5 hypotheses for den site selection related to den type, vegetation, and landscape characteristics in a dry prairie ecosystem in central Florida. We tracked 36 individual skunks to 757 den sites. Using discrete choice analysis, we found that male and nonbreeding female skunks at our study site were 5 times more likely to select a mammal burrow over a gopher tortoise (Gopherus polyphemus) burrow, that selection of a den site increased 34% for each 1‐burrow increase in the number of nearby burrows, and that selection of a den site increased 3% for every 10‐cm increase in a visual obstruction index. Similarly, breeding female skunks were more likely to select mammal burrows and shallow depressions over gopher tortoise burrows by 16‐fold and 13‐fold, respectively, and selection of a den site increased by 75% for every 1‐burrow increase in the number of nearby burrows. In contrast to previous studies that occurred in forested, mountainous environments elsewhere in the species' range, our findings suggest that den characteristics might be more important than landscape or vegetation characteristics to Florida spotted skunk den site selection in dry prairie. Additionally, the frequency of prescribed fires on the landscape did not appear to affect Florida spotted skunk den site selection. Thus, Florida spotted skunks in this ecosystem might be landscape generalists, thereby potentially limiting the ability of managers to control nest predation by this subspecies through habitat management. © 2019 The Wildlife Society.