bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of infliximab in real clinical practice
Authors: Aronova E. S. , Lukina G. V. 
Published: December 2019

A wide range of highly effective genetically engineered biological preparations introduced into clinical rheumatology in recent years causes a special interest in their safety.Purpose of the study. Evaluation of the safety of infliximab therapy in patients with rheumatoid arthritis.Materials and methods. The authors' own data, which analyzed the undesirable effects of infliximab in 135 patients with rheumatoid arthritis in actual clinical practice, are presented. A case report of the adverse reaction of combination therapy with leflunomide and infliximab is presented.Results and its discussion. The overall tolerability of infliximab was satisfactory. Adverse events were observed in 28.1 % of cases, including 19.1 % of patients (14.1 %) had serious side effects that required discontinuation of the drug.Findings. In most cases, infliximab is safe for use in actual clinical practice. Patients should be informed about the risks of undesirable effects and the need for a rheumatologist's examination before each infliximab administration before prescribing therapy.
Effectiveness of UVB-therapy with 311 nm wave-length and tacrolimus in treatment of psoriasis in children
Authors: Turovskaya S. N. , Matushevskaya E. V. 
Published: December 2019

Relevance. Of particular relevance in recent years has become the problem of psoriasis in children, it is noted an increase in cases of severe psoriasis refractory to traditional drug therapy, which together with a high incidence raises the questions of optimization of therapeutic interventions in this category of patients in the category of social.The purpose of the study. To study the efficacy and safety of UVB-phototherapy 311 nm, tacrolimus from pediatric patients with psoriasis.Material and methods. Under supervision there were 26 patients from 5 to 16 years old. All patients received UVB 311 nm phototherapy. The effectiveness evaluated in accordance with the dynamics of the indexes PASI, BSA, Quality of Life.Results. As a result of the course of UVB-therapy with 311 nm wave-length the number of patients with PASI 100 was 69 %, PASI 90 was 23 %, PASI 75 was 8 %. Index BSA were thus reduced to 81.5 %, DIKE improved by 65.3 %. The tolerance to UVB 311 nm was evaluated as very good. Adverse reactions such as transient erythema was observed in 11.5 % of patients, xerosis in 19.2 %.Conclusion. UVB 311 nm phototherapy is a highly effective and safe method of therapy of medium-severe psoriasis in children.
New horizons in systemic therapy of acne
Authors: Kruglova L. S. , Gryazeva N. V. , Nazarenko A. R. 
Published: December 2019

According to some authors, systemic corticosteroids can be used at the beginning of the course of treatment, which helps to accelerate the achievement of a significant effect and reduces the severity of side effects of retinoids. However, many issues of the combined use of isotretinoin and systemic corticosteroids in terms of the methodological approach remain unclear, which determined the purpose of this research.Material and methods. We observed 84 patients with moderate to severe acne. Among them, 51 (60.7 %) women and 33 (39.3 %) men, the average age of the patients was 17.1 ± 1.8 years. Patients were divided into 2 groups: moderate severe course — 1 group (n = 40), severe acne — 2 group (n = 44). Within the groups, depending on the therapy, the patients were divided into 2 subgroups: A subgroup — received isotretinoin in standard dosages, B subgroup — received isotretinoin also in standard dosages, while the initiation of therapy was carried out while taking systemic corticosteroid (1 month dexamethasone was prescribed at a dose 1 mg / day in 1 dose (in the morning)).The results of the study. The dynamics of the DICI index, the global IGA score, DICI showed comparable efficacy results in long-term follow-ups and early differences, an advantage was noted in the groups treated with dexetozone.Findings. Systemic retinoid is effective in preventing the formation of post-acne scars, which allows us to recommend it as the first choice in patients with risk factors for scar development. Important factors in the effectiveness of isotretinoin and the prevention of relapse are individual dose selection, the total cumulative and single dose and the duration of therapy for at least 6 months. The data obtained showed that the administration of a systemic corticosteroid in low doses (1 mg / day of dexamethasone) for 1 month of taking isotretinoin improves the effectiveness of therapy in the early stages of therapy and reduces the frequency / severity of side effects of retinoids.
Design of method for detecting single nucleotide polymorphisms of DNA non-coding region rs17185536: potential diagnostic value
Authors: Gorbenko A. S. , Stolyar M. A. , Komarovsky Yu. Yu. , Mikhalev M. A. , Potylitsyna V. V. , Vasilyev E. V. , Olkhovsky I. A. 
Published: December 2019

A large-scale study of DNA sequencing databases (Jorgenson E., et al., 2018) to search for hereditary susceptibility to early erectile dysfunction revealed an association with the rs17185536-T polymorphism regulating the expression of topologically associating domain, among which is the SIM1 gene, which plays an important role in maintaining mass body and sexual function. The proximity of the rs17185536 locus to the CCNC (cyclin C), PRDM13 (histone methyltransferase) and USP45 (ubiquitin-specific peptidase 45) genes suggests the possible involvement of this polymorphism in the pathogenesis and other diseases associated with impairments of these genes.Materials and methods. The study included a total of 280 people: 81 of which were healthy donors, 116 pregnant women, 25 patients with polycythemia vera, 29 with essential thrombocythemia, and 29 with primary myelofibrosis.Results. Using the original method of determining the polymorphism rs17185536, the allele of specific PCR-RT showed that the prevalence of the T allele among all examined patients was 19 %, and variants of the genotypes: C/C with 73 %, C/T with 23 % and T/T with 4 %, which corresponds to Winkler e. a. data. The absence of statistically significant differences in the frequency of occurrence of this polymorphism in the pathology of pregnancy and in chronic myeloproliferative diseases indicates a low probability of involvement of rs17185536-T in the pathogenesis of these diseases. In the group of pregnant women, there is an association of the rs17185536-T allele with obesity, uterine fibroids and the development of preeclampsia.Conclusions. For the first time, using the original method of analysis, it was confirmed that the Russian population has a comparable prevalence of the gene of hereditary susceptibility to impotence. Despite the topographic proximity of the rs17185536 locus to the genes regulating the repair and functioning of DNA, its polymorphisms do not affect the risk of chronic myeloproliferative diseases developing. The association of the rs17185536-T allele with the risk of developing a pregnancy pathology requires further study.
Factors Affecting Prolonged Stay in Postoperative Period in General Surgery Intensive Care Unit
Authors: ÜSTÜN Mehmet , KILINÇ Gizem , KARACA Avni Can , DEMİR Halit Batuhan , ŞENOĞLU Nimet , AYDIN Cengiz 
Published: December 2019

Aim:Prolonged stay in intensive care unit is associated with a high risk of mortality. Predictability of it is important to reduce mortality. The aim of this study is to determine the factors affecting prolonged stay in secondary general surgery intensive care unit.Materials and Methods: Between January 2014 and October 2017, 68 patients with prolonged stay undergoing general surgery ICU follow-up in the postoperative period after the general surgical procedure and the same number of randomly selected patients with similar characteristics were compared in two groupsResults:The median age of the patients with prolonged stay was 69,00 (22,50) and the median age of the patients in the control group was 59,00 (14,75) (p &lt; 0,001).In prolonged stay group, 59 patients underwent abdominal emergency surgery, and 9 patients underwent abdominal elective surgery. The number of patients undergoing abdominal emergency procedures in the control group was 23, and the number of patients undergoing abdominal elective procedure was 45 ( p=0,001). Fourty eight of the patients in the prolonged stay group had mortality, 7 of the patients in the control group had mortality (p=0,001). As a result of multivariate analysis; in the prolonged stay group, emergency abdominal surgical procedure rate (p &lt;0.001) (Odds ratio:12.983), age (p = 0.006) (Odds ratio:0.96) and mortality rate (p &lt;0.001) (Odds ratio: 20,91) was found to be statistically significant.Conclusion: . Emergency abdominal surgical procedure, age and high mortality rate are associated with prolonged stay.
URGENSI MENCIPTAKAN PEMBELAJARAN YANG BERKUALITAS BAGI SEORANG GURU
Authors: B Abdul Hamid 
Published: December 2019

Learning is all efforts of teaching and learning in order to create effective and efficient teaching and learning process. Learning is a process to help students to learn well. The learning activities are expected to be a better change for students who study. These changes are related to cognitive, psychomotor, and affective aspects. The main purpose of learning is to provide opportunities for students to express their abilities so that there is a better change in themselves. There are several factors that affect learning outcomes, including (1) Student, (2) Teacher, and (3) Learning Designs. To achieve these learning objectives, it is necessary to have the skills of a teacher in designing quality learning. There are several methods that can be done by teachers to create quality learning, namely: (1) Understanding Student Characteristics, (2) Developing Learning Implementation Plans, (3) Building Student Learning Motivation, (4) Mastering Learning Materials, (5) Using Innovative Learning Media, (6) Using Innovative Learning Models, (7) Interspersing with Joke in Learning Activities, (8) Conducting feedback, and (9) Conducting Evaluations.
KAJIAN MAKNA DAN FUNGSI PIS BOLONG DALAM UPACARA DEWA YAJNA BAGI UMAT HINDU DI KOTA PALU
Authors: Merthawan Gede 
Published: December 2019

Pis bolong merupakan sarana upakara yang memiliki kedudukan yang sangat penting yaitu inti dari sebuah yajna. Dalam hakekatnya pis bolong yang digunakan dalam upacara dewa yajna yakni pis bolong asli yang mengandung unsur panca datu yang meliputi perak, tembaga, emas, besi, dan kuningan yang mewakili panca dewata dalam ajaran agama Hindu. Namun pada saat ini umat Hindu yang ada di Kota Palu menggunakan pis bolong jenis seng yang berbahan dasar dari seng atau hanya berbahan dasar dari satu logam saja yang hanya dibuatkan lubang tanpa disertai huruf pada kedua sisinya.
Rumusan masalah dalam penelitian ini adalah sebagai berikut: 1) Bagaimanakah makna dan fungsi pis bolong dalam upacara dewa yajna bagi umat Hindu di Kota Palu? 2) Bagaimanakah nilai-nilai religius penggunaan pis bolong dalam upacara dewa yajna bagi umat Hindu di Kota Palu? Penelitian ini memiliki tujuan yaitu: 1) Untuk mengetahui makna dan fungsi pis bolong dalam upacara dewa yajna bagi umat Hindu di Kota Palu. 2) Untuk mengetahui nilai-nilai religius penggunaan pis bolong dalam upacara dewa yajna bagi umat Hindu di Kota Palu.
Teori yang digunakan untuk membedah permasalahan adalah Teori Simbol, Teori Religi dan Teori Nilai. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Penentuan informan menggunakan teknik purposive sampling. Informan terdiri dari pinandita atau pemangku, sarati, parisadha, tokoh umat dan beberapa umat Hindu di Kota Palu. Teknik yang digunakan dalam pengumpulan data adalah observasi, wawancara, studi kepustakaan, dokumentasi. Instrumen penelitian yaitu peneliti sebagai instrumen kunci. Teknik analisis data dilakukan melalui tiga tahap yaitu: reduksi data, penyajian data dan penarikan kesimpulan.
Hasil penelitian: Makna dan fungsi pis bolong dalam upacara dewa yajna khususnya pada daksina yaitu : Pis bolong panca datu bermakna sebagai lambang atau simbol dari windu (O) yang berarti kekosongan atau kesucian tanpa noda yang merupakan inti dari pada sebuah yajna dan sebagai lambang kekuatan panca dewata (panca datu) yang dapat menghadirkan Ida Sang Hyang Widhi Wasa. Fungsi pis bolong yaitu: Sebagai sarana untuk menghubungkan diri kepada Ida Sang Hyang Widhi Wasa dan sebagai sesari. Nilai-nilai religius penggunaan pis bolong dalam upacara dewa yajna khususnya pada daksina yaitu: Nilai kejujuran dan nilai tanggung jawab.
RELAÇÃO ENTRE TEMPO DE USO E QUALIDADE DE VIDA EM USUÁRIOS DE PRÓTESE TOTAL NO ESTADO DO AMAPÁ
Authors: Celis de Cardenas Anneli Mercedes , Coelho Paraguassu Eber 
Published: December 2019

Introduction: É crescente o número de pessoas sem nenhum dente no Brasil, 11% da população é desdentada total, o que corresponde a um montante de 16 milhões de pessoas e 33% da população faz uso de algum tipo de prótese dentária. O número de dentes presentes na cavidade bucal é pequeno, fazendo com que problemas sociais, físicos, psicológicos e nutricionais afetem diretamente a qualidade de vida dos edêntulos.
Objetive: O objetivo deste artigo é relacionar o tempo de uso de próteses totais com a qualidade de vida destes usuários.
Methodology: Foram entrevistados 299 usuários de prótese total mucossuportada e 48 usuários de prótese total implantossuportada por meio de dois questionários, o Oral Health Impact Profile-14Br (OHIP-14Br) e questionário sociodemográfico.
Results: Ususarios de prótese total possuem melhor qualidade de vida em todas as variáveis comparadas com ussuarios de prótese mucossuportada e usuários de prótese total mucossuportada apresentam grande relação entre qualidade de vida e tempo de uso das próteses.
MITIGASI BENCANA BANJIR UNTUK MENGURANGI DAMPAK TERHADAP LINGKUNGAN DAN KEHIDUPAN SOSIAL MASYARAKAT
Authors: Indra Khaidir  
Published: December 2019

Banjir adalah suatu bencana alam yang datang di saat musim hujan tiba. Intensitas air yang tinggi saat musim hujan datang mengakibatkan dampak banjir yang sangat dirasakan bagi korban banjir, mulai dari terganggunya aktivitas masyarakat, lalu lintas menjadi padat dan macet, terserang penyakit, serta banyak masyarakat yang harus mengungsi karena rumahnya terendam banjir. Salah satu penyebab banjir karena semakin tinggi tingkat perubahan tata guna lahan dari sawah ke permukiman, pelebaran jalan , betonisasi pada jalan-jalan komplek permukiman yang mana hal ini menyebabkan berkurangnya daerah resapan sehingga aliran permukaan (run off) menjadi semakin besar, disamping itu banyaknya sampah dan lumpur menyebabkan penyumbatan aliran air pada saluran drainase. Kondisi inilah yang menyebabkan genangan air jika tingginya intensitas curah hujan karena debit limpasan yang ada sudah tidak tertampung lagi oleh kapasitas saluran. Masyarakat adalah yang pertama merasakan dampak yang diakibatkan oleh banjir ini. Selain itu masyarakat jugalah yang bertanggumg jawab untuk menjaga dan melestarikan lingkungan sekitar, tetapi yang terjadi adalah sebaliknya, masyarakat sering tidak memperhatikan lingkungan sekitar dan bahkan merusak lingkungan yang ada. Pada gagasan tertulis ini penulis akan menjelaskan betapa pentingnya menjaga lingkungan dan dampak yang diakibatkan oleh banjir tersebut.
Estudio Comparativos entre Mapas Conceptuales y Mentefactos
Authors: De la Herrán Agustín , Linares Alvaro Manuel , Mendoza Navarrete Martha Lorena 
Published: December 2019

RESUMEN
La educación actual se ha caracterizado por el empleo de técnicas educativas encaminadas a facilitar y mejorar la calidad del aprendizaje. Tanto los mapas conceptuales, como los mentefactos, son herramientas encaminadas a lograr los propósitos antes señalados, sin embargo, ambos recursos presentan destacadas similitudes y diferencias, también existen marcados aspectos positivos y negativos entre ambos organizadores gráficos. Este artículo surge de esta situación, tomando como base la idea de proponer un recurso u organizador gráfico, que sea capaz de mezclar tanto mapas como mentefactos, para que sea capaz de aprovechar las potencialidades de cada uno, y minimizar sus aspectos negativos.
También, se ha incluido una breve descripción y conceptualización de ambos organizadores, profundizándose en sus aspectos tanto negativos como positivos, ventajas, diferencias y similitudes.
ABSTRACT:
Nowadays education has been characterized by the use of educational techniques to facilitate and improve the learning quality. Both concept maps and “mentefactos” are tools designed to achieve the purposes mentioned above, however, both have resources highlights similarities and differences, there are also marked aspects between positive and negative graphic organizers. This article arises from this situation, based on the idea of proposing an action or graphic organizer that is able of mixing well as maps as “mentefactos”, to be able to exploit the potentialities of each, and minimize its negative aspects. Also, it has included a brief description and conceptualization of both organizers, deepening in their negative and positive aspects, advantages, differences and similarities.
Universidad y su Función Territorial para el Desarrollo Local
Authors: Calle García Aldrin Jefferson , Calle  García Jonás Sneider , Yoza Rodríguez Narciso Roberto , Sánchez Chóez Liliam Rosalía 
Published: December 2019

Este trabajo de investigación fue motivado ante las deficiencias de articulación entre las universidades y actores territoriales para el desarrollo local, planteando como objetivo diseñar un modelo que logre dicha articulación. El estudio fue de cohorte cuasi-experimental, se aplicaron entrevistas y encuestas como métodos empíricos, resultados que permitieron obtener las conclusiones, las mismas que viabilizaron el diseño del modelo, el cual tiene como eje articulador el liderazgo que debe desarrollar la universidad como ente de desarrollo de los pueblos, generando sinergia con los gobiernos locales descentralizados y los demás actores territoriales, propiciando una planificación que permita cambios hacia el desarrollo sostenible en el ámbito social del territorio. De la misma forma se detecta que el tema desarrollo local abarca muchos campos y está siendo introducido con énfasis en los programas que presenta el gobierno central, cada uno de ellos orientado con el plan nacional del buen vivir, se destaca también el rol de la cooperación internacional dentro del proceso de desarrollo endógeno.
Palabras clave: Desarrollo local, actores territoriales, desarrollo endógeno, universidad, desarrollo sostenible
Summary
This research work was motivated by the deficiencies of articulation between universities and territorial actors for local development, aiming to design a model that achieves this articulation. The study was a quasi-experimental cohort, interviews and surveys were applied as empirical methods, results that allowed the conclusions to be obtained, which enabled the design of the model, which has as articulating axis the leadership that must develop the university as a body of Development of the towns, generating synergy with the decentralized local governments and the other territorial actors, propitiating a planning that allows changes towards the sustainable development in the social area of ​​the territory. In the same way it is detected that the topic of local development covers many fields and is being introduced with emphasis in the programs presented by the central government, each of them oriented with the national plan of good living, also highlights the role of cooperation Within the process of endogenous development.
Keywords: Local development - territorial actors - endogenous development – University - sustainable development.
PARTICIPACIÓN EN LA PUBLICACIÓN: Autor: Aldrin Jefferson Calle García. Mg. Co – Autores: Jonás Sneider Calle García. Mg, Narciso Roberto Yoza Rodríguez. Mg, Liliam Rosalía Sánchez Chóez. Mg.
Percepción de los universitarios en el aprendizaje del inglés
Authors: Álvarez Zapata Mary Cruz , Hernández Romero Gladys 
Published: December 2019

La presente investigación muestra como en la actualidad el idioma inglés se ha vuelto indispensable en la formación de los estudiantes de la Licenciatura en Contaduría Pública de la Universidad Juárez Autónoma de Tabasco, y cuál es la perspectiva que ellos tienen respecto al aprendizaje del mismo. El educarse en una nueva lengua es un reto hoy en día, sin embargo, adquirirla genera una ventaja competitiva para los futuros profesionistas. Para la obtención de datos se implementó un estudio empírico basado en una muestra intencional o de conveniencia de 155 universitarios. Reflejando que los alumnos no solo aprenden el idioma por obligación, sino que también lo hacen para obtener beneficios dentro del ámbito laboral y social, ya que vivir en un país cada vez más globalizado, lo exige. El aprender inglés es más fácil para los estudiantes cuando éstos emplean diferentes herramientas de aprendizaje tales como las prácticas con especialistas, presencial con técnicas y el utilizar software digitalizado.

Palabras claves
Lengua extranjera, educación bilingüe, tecnología avanzada, profesionistas, globalización.

Abstract
The present work shows how in the present day the English language has become essential in the formation of the Public Accounting degree students, in the Juarez Autonomous University of Tabasco, and the view they have of the learning of this language. Learning a new language is a challenge nowadays, however, acquiring this knowledge gives a competitive advantage for the future professionals. For the obtaining of this information, an empirical study was applied on an intentional or convenience sample of 155 university students. Reflecting that students don’t learn English just because they have to, but they also do it to obtain benefits among the labor and social environment, since living in a globalized country, demands it. Learning English is easier for students when they use different learning tools, such as talking with specialists, techniques and using digitalized software.
Keywords
Foreign language, Bilingual education, advanced technology, professionals, globalization.
Percepción y actitudes de los estudiantes sobre el m-learning en la asignatura Ingeniería del software
Authors: Mero Suárez Karina Virginia , Merchán Carreño Edwin Joao , Mero Suárez Carlos Renán 
Published: December 2019

Los dispositivos móviles, son una herramienta de gran importancia en el ámbito educativo. El presente artículo tiene como objetivo determinar la percepción y actitud de los alumnos para valorar la implementación del uso de los móviles en la asignatura Ingeniería del Software en la carrera en de Ingeniería en Sistemas Computacionales, de la Universidad Estatal del Sur de Manabí, Ecuador. El tipo de investigación fue exploratorio-descriptivo, con un diseño no experimental. La muestra estuvo conformada por 42 estudiantes que formaron parte de la investigación, en el curso 2018-2019. Dentro de los resultados se destaca que los alumnos en un 95,23% consideran una mayor utilidad del dispositivo móvil, como medio de comunicación. Un 88, 09% lo utilizan para revisar el correo y el 78,57% lo emplean para la gestión de información científica y académica. Para el análisis de resultados se empleó el programa SPSS. Los resultados alcanzados permiten concluir que se logró determinar la percepción y actitud de los educandos y docentes, para la posible implementación del aprendizaje móvil en la asignatura Ingeniería del Software, de la carrera de Ingeniería en Sistemas Computacionales, de la Universidad Estatal del Sur de Manabí, Ecuador y de acuerdo con la información obtenida los estudiantes cuentan con los dispositivos móviles, manifiestan buena disposición para usar los dispositivos móviles en sus prácticas educativas.