bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSTRUCTION OF THE STRUCTURE OF RURAL ELECTRIC NETWORKS TAKING INTO ACCOUNT THE AVAILABILITY OF RENEWABLE SOURCES OF ELECTRICITY
Authors: Zabolotnyi Anatolii , Fedosha Denys , Dyachenko Vera , Liush Yuliya 
Published: December 2024

It is noted that although the share of renewable electricity sources continues to grow and develop rapidly, the industry still faces many challenges, including how to continue to reduce electricity losses and annualized costs, improve operation and maintenance efficiency, maintain grid stability, ensure safety and reliability of the power supply system containing renewable sources of electrical energy.
It is shown that an effective solution to these problems is possible only on the basis of the analysis of the prospects for the development of local electric power systems that contain renewable sources of electric energy, the development of technical and organizational support mechanisms that will contribute to the construction of modern system (schematic) solutions.
It is proposed to apply the potential surface method for building the optimal structure of the rural electrical network during its design and modernization in the presence of renewable sources of electrical energy, which allows optimizing the structure of the network from the point of view of electrical energy losses and reducing annualized costs.
The algorithm for forming the structure of power supply systems is described, which implements the simultaneous solution of the tasks of determining the number of load nodes, distributing electrical receivers between them, determining the design of power sources,taking into account the discreteness of the design of system elements.
The results of numerical modeling based on the proposed algorithm are presented on the example of solving the problem of reconstruction of a section of the rural electricity network.
Effect of Fullerene C60 on Tomato Plants
Authors: Buziashvili Anastasiia , Prylutska Svitlana , Yemets Alla 
Published: December 2024

Background. Fullerenes, one of the allotropic forms of carbon, are the focus of intensive research in nanobio­technology. Due to their unique physicochemical properties, there is growing interest in using them to enhance plant productivity and provide protection against various stresses. However, data on the effects of fullerenes on different plants are often contradictory.
Objective. To investigate the effect of colloidal water-soluble fullerene C60 on various stages of tomato deve­lopment.
Methods. The study examined the influence of fullerene C60 (0–50 µg/ml) on the seed germination of the Money Maker cv. and the growth and development of seedlings and adult plants. For this purpose, morphophysiological parameters such as shoot and root length, number of lateral and adventitious roots, fresh weight, accumulation of photosynthetic pigments, and nitric oxide (II) were assessed.
Results. Both positive and some phytotoxic effects of fullerene C60 on tomatoes were observed. Specifically, inhibition of seedling growth and a decrease in chlorophyll b and carotenoid content in adult plants were noted. Positive effects included an increased seed germination rate, higher fresh weight, greater length and number of adventitious roots in tomatoes grown in the presence of fullerene C60, and a higher nitric oxide (II) content in adult plants, which may contribute to enhanced stress resistance.
Conclusions. Fullerene C60 at a concentration of 25 μg/ml has a predominantly positive effect on tomato development and may be considered a promising nanomaterial for plant biotechnology.
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions
Authors: Lu Junlin , Li Jiarui , Wang Lu , Chen Yao , Wu Yulun , Zhang Ziying , Zhang Jingying , Gao Feng , Jia Chaoran , Bao Yongli , Yang Xiaoguang , Song Zhenbo 
Published: December 2024

Cervical cancer poses a significant threat to women&#039;s health, underscoring the critical need for the development of low-toxicity, high-efficacy pharmacological drugs that specifically target cervical cancer cells. During cancer progression, elevated glucose consumption leads to a pervasive state of glucose deficiency within the tumor microenvironment (TME). Consequently, it is imperative to identify pharmacological agents capable of effectively killing cancer cells under conditions of low-glucose availability within the TME. Previous studies have demonstrated that Gboxin, a small molecular compound, effectively inhibited the growth of Glioblastoma (GBM) by targeting the activity of the ATP synthase complex, while exhibiting no detrimental effects on normal cells. However, the role and underlying molecular mechanisms of Gboxin in cervical cancer cells within a low-glucose microenvironment remain inadequately understood. This study suggested that Gboxin significantly promoted autophagy, apoptosis, and ferroptosis of cervical cells under low-glucose conditions while had no obvious effect on cell survival under normal conditons. Further study suggested that Gboxin inhibited mitochondrial function under low-glucose culture conditions while showing no significant changes on glycolysis. Mechanistic analysis revealed that Gboxin inhibited ATP synthesis and activated the AMPK signaling pathway by targeting mitochondrial complex V. Furthermore, the increased AMPK activation subsequently promoted autophagy and reduced p62 protein levels. The decreased levels of p62 protein facilitated the degradation of Nrf2 by regulating p62-Keap1-Nrf2 axis thereby diminishing the antioxidant capacity of cervical cancer cells, ultimately leading to the induction of apoptosis and ferroptosis. This study provided a better theoretical basis for exploring Gboxin as a potential drug for cervical cancer treatment.
Functional assessment of citral dietary supplementation on growth performance, intestinal parameters, and specific activity of the digestive enzymes of Sardinella brasiliensis reared in recirculating aquaculture system
Authors: Michelotti Bruna Tomazetti , Owatari Marco Shizuo , Magnotti Caio , Klinger Ana Carolina Kohlrausch , Palma Ulyssses da Silva , Santos Marina Cesconeto dos , Descovi Sharine Nunes , Cerqueira Vinícius Ronzani , Costa Sílvio Teixeira da , Bianchin Letícia Bogoni , Baldisserotto Bernardo 
Published: December 2024

This study evaluated the effects of dietary supplementation with citral on growth performance and intestinal parameters, and specific activity of the digestive enzymes of Sardinella brasiliensis. 240 juvenile S. brasiliensis were randomly distributed in a recirculating aquaculture system (RAS) composed of 12 circular tanks of 150 L (n = 20 per tank). A diet without citral addition (control) and three diets containing different levels of citral inclusion (0.5, 1.0 and 2.0 mL kg*feed–1) were used in the fish feeding management during 20 days. The indexes of zootechnical performance, survival, weight gain, specific growth rate, feed conversion and condition factor of the fish were verified, as well as digestive enzymes and histological analysis. A significant positive relationship was found between citral supplementation and fish survival. In the specific activity of digestive enzymes, dietary citral supplementation at 2.0 mL* kg feed–1 increased lipase and amylase activity. Citral supplementation positively influenced the number of villi and intestinal crypt depth. Furthermore, the inclusion of citral at 0.5 mL kg*feed–1 increased the intestine diameter of the fish. The results of the experiment suggest that the addition of citral as an additive in the diet of S. brasiliensis improved the survival of fish.
Experimental Evaluation of Low-Carbon Cement and Its Application to the Oil and Gas Industry
Authors: Findlay Tristin , Tabatabaei Maryam , Dahi Taleghani Arash 
Published: December 2024

Summary
This study initiates a series of tests to examine the application of Type IL cement for well-cementing operations. Type IL cement is a blend of 5–15% limestone with Type I/II Portland cement. This substitution by reducing the amount of CO2 emitted from cement plants can be aligned with sustainability efforts in the cement industry. We first measured the properties of cement slurry made of Type IL cement and compared them with specifications for the well cementing. The properties of hardened cement including the compressive strength and bonding strength were also examined. For compressive strength measurement, both cubic and cylindrical samples were prepared. To measure the bonding strength, the modified pushout test was used. We also investigated the effect of severe environments on the strength reduction of the hardened cement. In addition, the scaled abandonment plugging setup was used to quantify the sealing capabilities of Type IL cement in a well-plugging scenario. To force nitrogen flow through, differential pressure was applied to the system by decreasing the pressure above the plug-in controlled timesteps. We found that Type IL hardened cement offers substantial sealing capabilities compared with data available in the literature, although the leakage rate seems to gradually increase with each increase in differential pressure.
The Autonomic Craving Signature: physiological signals as a daily-life biomarker of craving
Authors: Baillet Emmanuelle , Serre Fuschia , Si-Mohammed Hakim , Romao Cassandre , Bruneau Arthur , Vacher Chloé , Monseigne Thibaut , Jeunet-Kelway Camille , Auriacombe Marc 
Published: December 2024

Abstract

Craving variations have been shown to be prospectively associated to relapse and are a target for treatment in substance use disorders (SUD). We show that a set of physiological features captured in daily life can distinguish within-day craving from no-craving states, among SUD participants in a 14-day multimodal study. Craving was assessed Signal-contingent and event-contingent. Continuous recording of physiological signals was conducted daily. After labeling samples as “craving” and “no-craving” using a double-check verification, features of each signal were extracted, normalized and standardized and a principal component analysis was applied. Using Support Vector Machines and Linear Discriminant Analysis classifiers, physiological signals allowed to discriminate craving from no-craving episodes with a high cross-validation accuracy (73.6% and 72.2% respectively). This finding is an important breakthrough that paves the way to a biomarker of craving in daily life.
Heterojunction design of ZnO/α-Fe2O3 with dual enhancement of ion/electron transport for energy storage
Authors: Wu Qinyu , Wang Shuai , Cao Rui , Lei Qian , Ma Ziyang , Ma Yangzhou Z. , Xia Ailin L. , Song Guangsheng S. 
Published: December 2024

Abstract

Transition metal oxides (TMOs), such as Fe2O3 and ZnO, are attractive as anode materials for battery application due to the high theoretical specific capacity, environmental friendliness, and low price. However, poor electron conductivity or poor ion migration rate significantly limit the application of TMOs in lithium-ion batteries. To overcome both challenges, a heterostructured construction consisting of two different transition metal oxides proves to be effective for cycling stability and rate performance. In the present work, high-capacity α-Fe2O3 and ZnO are combined into a nanocomposite with heterojunction by facile wet ball-milling process. Microstructural observation shows that the irregular ZnO surface is tightly wrapped by needle-like Fe2O3, and the interface of the two phases is in close contact at the atomic level. According to the energy band theory, heterojunction is formed at the interface. Electrochemical tests showed that the construction of heterojunction promotes the release of inert lithium from the inner ZnO, thus improving the initial Coulombic efficiency (ICE). The two phases synergistically regulate the electron/ion transport of the composites. In addition, The heterojunction at the interface of the two phases achieved rapid electron transport, resulting in excellent cycling and rate perfomance (∼472 mA h/g at 200 mA/g after 270 cycles). In fact, the straightforward and scalable technique without carbon which is used on this heterostructured metal oxide anodes provides a viable solution for future industrial-grade preparations.
Differential miRNA Expression in Neuronal-Derived Extracellular Vesicles as potential biomarker for Frontotemporal Dementia and Bipolar Disorder
Authors: Serpente Maria , Delvecchio Giuseppe , Fenoglio Chiara , Consoli Lorena Di , Giudici Giulia , Borracci Vittoria , Rotondo Emanuela , Arcaro Marina , Sacchi Luca , Pintus Manuela , Ghezzi Laura , Ferro Adele , Prunas Cecilia , Callari Antonio , Scola Elisa , Triulzi Fabio , Arighi Andrea , Brambilla Paolo , Galimberti Daniela 
Published: December 2024

Abstract

Frontotemporal Dementia (FTD) and Bipolar Disorder (BD) share overlapping symptoms, complicating diagnosis. FTD, especially linked to C9orf72 expansions, often mimics BD, highlighting the need for reliable biomarkers. This study aimed to differentiate FTD from BD using miRNA profiles in neuronal-derived extracellular vesicles (NDEVs). A cohort of 100 subjects was analyzed: 40 FTD (20 sporadic, 20 C9orf72 carriers), 40 BD, and 20 healthy controls. NDEVs were isolated from plasma and profiled using real-time PCR. Among 754 miRNAs, 11 were significantly deregulated in FTD and BD. miR-152-5p was downregulated in sporadic FTD, while let-7b, let-7e, miR-18b, and miR-142-5p were altered in C9orf72 carriers. BD patients showed distinct patterns in miR-331-5p, miR-335, and miR-345 compared to FTD. Bioinformatics analysis revealed no common protein-coding targets but significant overlap in lncRNA targets, particularly XIST, NEAT1, and KCNQ1OT1, suggesting a shared molecular mechanism. These miRNA signatures can differentiate FTD from BD, especially in C9orf72-related cases, and offer insights into disease pathways. Further research is needed to validate these findings and explore their clinical application.
A superconducting metamaterials transmission line resonator: experimental verification of the non-uniform mode spacing
Authors: Tang Qing , He Jia Xin , Chai Ya Qiang , Ouyang Peng Hui , Wei Lian Fu 
Published: December 2024

Abstract

Superconducting transmission line resonators (TLRs) have been widely applied to circuit quantum electrodynamical systems for superconducting quantum computation and single-photon detections. Recently, such a right-handed TLR has been generalized to electromagnetic metamaterials (MTMs), and its unconventional mode structure has been experimentally characterized [H. Wang et al., Phys. Rev. Applied 11, 054062 (2019)]. Here, we demonstrate another kind of MTM TLR, a superconducting quarter-wavelength composite right/left-handed (CRLH) TLR composed of lumped-elements. We design the devices and analyze their transport properties by developing a real-space approach, wherein the physical parameters at the device boundaries are utilized conveniently. Superconducting MTM TLRs with typical three unit cells were experimentally prepared by etching a superconducting aluminum film on a SiO2 substrate, and their microwave transport properties were measured at low temperatures of 50mK. The results show that the modes spacing in such a quarter-wavelength CRLH-TLR is non-uniform due to the nonlinear dispersion relation. This implies that they could be utilized to encode the superconducting qubits, analogously to the usual ones encoded by the Josephson devices.
Levodopa influence on turning dynamics in people with Parkinson’s disease
Authors: Pillai Lakshmi , Landes Reid D. , Virmani Tuhin 
Published: December 2024

Abstract

Turning behaviors are affected in people with Parkinson’s disease (PwPD) leading to falls and Freezing of Gait (FOG). Levodopa therapy is commonly recommended for PwPD to help alleviate motor symptoms. Knowledge of turning dynamics with levodopa therapy is limited and could improve clinical care. We enrolled 44 PwPD already on levodopa therapy and analyzed their turns on an instrumented gait mat. Participants made 180-degree turns in their OFF-state (> 8 hours off levodopa) then ON-state (1 hour after levodopa). Thirteen turn measures were assessed for changes between the OFF to ON-state. Turns in the ON-state had faster stride-velocity, fewer steps, and trending towards lengthier turns, better foot ground contact, and decreased variability in stance-time. Regression modeling suggested greater improvement in turn stride-velocity, better foot contact, and lengthier turns with longer levodopa duration, and fewer steps and lower variability in stance-time with higher FOG severity. Our data suggests worse OFF-state function and retained levodopa responsiveness leading to larger improvement in turn measures in those on levodopa longer (or longer disease duration) and in those with levodopa unresponsive FOG. Our results provide important evidence for continued aggressive levodopa management to improve mobility during turns even in advanced Parkinson’s disease.
A Quantum Chemical, Biological, and Experimental Analysis of Newly Synthesized Schiff-based PEI CA/N-GQDs Nanomaterials: Evaluation of Anticancer Potential in Human Neuroblastoma Cell
Authors: Kilic Murat , Gunes Buket Altinok , Kirlangic Omer Faruk , Aslan Aysenur , Ketenoglu Didem , Kirlangic Fatma Zeynep , Elci Pinar Mualla , Mert Faruk , Gulec Neslihan , Boyacioglu Bahadir , Unver Huseyin , Chaterjee Ashok , Yildiz Mustafa 
Published: December 2024

Abstract

In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The synthesized material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well as theoretically by DFT method. In addition to their biological activities, their cytotoxic, apoptotic and cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According to the UV-Vis data, we observed that the material exhibits phenol-imine/keto-amine tautomerism, a phenomenon common in 2-hydroxy Schiff bases that help to explain the various properties of material. Furthermore, this material predominantly exists in the keto-amine form. The material demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed that it binds to DNA through an electrostatic interaction and causes oxidative and hydrolytic cleavage in DNA, which results in an increase in ROS in the cell, an activation of the CASPASE-3, leading the cells undergo apoptosis, and inhibiting cell division in the G1/S phase. We believe that the chemical properties of the Schiff-based PEI N-GQDs make them a superior carrier molecule for cancer treatment. Furthermore the anticancer properties of the Schiff-based PEI-CA/N-GQDs suggest their potential as a therapeutic agent for neuroblastoma.
Traps suitability to monitor the above- and below-ground insect diversity in different forage production systems of the semi-arid regions of India
Authors: Govindasamy Prabhu , MC Keerthi , Sujayanand G.K. , Bhargavi H.A. , Mahesha H.S. , Sriniv R. , Choudhary Mukesh , Chaudhary Manoj , Prasad Mahendra , Kumar Sonu , Tyagi V.C. , Deb Dibyendu , Sivakumar U 
Published: December 2024

Abstract

Insects play vital roles in ecological processes and are recognized as fundamental elements of global biodiversity. Assessments of insect biodiversity from different ecosystems are essential to knowing the status of insect diversity. Therefore, the insect biodiversity of three different forage production systems (annual, perennial, and grassland) in the Bundelkhand region of India was assessed by employing three sampling methods: manual insect sweep net collection, yellow sticky traps, and pitfall traps. The experiment runs for three seasons (rainy, winter, and summer) from 2019 to 2021. The findings from this study indicate that the choice of insect traps significantly influences the assessment of insect diversity. Yellow sticky traps were more efficient in documenting species richness, abundance, and Shannon-Wiener diversity. However, all three traps were comparable in terms of measuring insect dominance. Seasonal variations were observed, with the summer season exhibiting higher species numbers (16.6±1.3) and abundance (409.7 ±76.4). The study also highlighted the influence of climatic factors and study years on insect diversity, emphasizing the need for suitable sampling techniques to estimate abundance accurately. The interaction effect of year-by-traps showed that yellow sticky traps were more effective than sweep nets and pitfall traps in 2019–2020 and 2020–2021. The study identified the most suitable meteorological weeks for each trapping method. Yellow sticky traps were effective during the 4–12th, 21st, 24th, 35th, and 38th standard meteorological week (SMW), while sweep nets and pitfall traps showed efficacy during the 23rd, 24th, 35th, and 36th SMW. The research emphasizes the importance of selecting appropriate sampling methods and considering seasonal and yearly variations in estimating insect diversity. Our study findings contribute valuable insights into insect biodiversity in the forage production systems of the Bundelkhand region, providing a foundation for future conservation strategies.
Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer
Authors: Huang Xu , Hong Lin , Lv Yufan , Li Kejun , Zhang Zengxing , Deng JunJian , Shen Lei 
Published: December 2024

Abstract

While chemotherapy and radiotherapy may alleviate symptoms and prolong survival in patients with advanced gastric cancer, their efficacy is constrained. In contrast, immunotherapies, including immune checkpoint inhibitors, T-cell transfer therapy, and therapeutic vaccines, demonstrate greater potency in treating advanced gastric cancer. This study developed a single-injection peptide hydrogel-based nanovaccine therapy for gastric cancer treatment. The therapy employs a RADA32 peptide hydrogel, sensitive to metal ion concentration, encapsulating manganese ions and HPPS nanovaccines (containing antigen peptides and CpG-ODN) to facilitate a stable, sustained release of the nanovaccine. This strategy activates both the toll-like receptor 9 and cGAS-STING signaling pathways in antigen-presenting cells, enhancing the body's effective recognition and response to antigens. The system's efficacy was confirmed using the model antigen OVA and the gastric cancer-specific antigen MG7-related peptide. This approach offers a novel strategy for clinical anti-tumor vaccine administration and may be applicable in preventing and treating gastric cancer.
V- and VL-Scores Uncover Viral Signatures and Origins of Protein Families
Authors: Anantharaman Karthik , Zhou Kun , Kosmopoulos James , Dieppa Etan , Badciong Peter 
Published: December 2024

Abstract

Viruses are key drivers of microbial diversity, nutrient cycling, and co-evolution in ecosystems, yet their study is hindered due to challenges in culturing. Traditional gene-centric methods, which focus on a few hallmark genes like for capsids, miss much of the viral genome, leaving key viral proteins and functions undiscovered. Here, we introduce two powerful annotation-free metrics, V-score and VL-score, designed to quantify the “virus-likeness” of protein families and genomes and create an open-access searchable database, ‘V-Score-Search’. By applying V- and VL-scores to public databases (KEGG, Pfam, and eggNOG), we link 38−77% of protein families with viruses, a 9−16x increase over current estimates. These metrics outperform existing approaches, enabling precise detection of viral genomes, prophages, and host-derived auxiliary viral genes (AVGs) from fragmented sequences, and significantly improving genome binning. Remarkably, we identify up to 17x more AVGs, dominated by non-metabolic proteins of unknown function. This innovation unlocks new insights into virus signatures and host interactions, with wide-ranging implications from genomics to biotechnology.