bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterus transplantation: joys and frustrations of becoming a ‘complete’ woman—a qualitative study regarding self-image in the 5-year period after transplantation
Authors: Järvholm Stina , Enskog Anders , Hammarling Catrina , Dahm-Kähler Pernilla , Brännström Mats 
Published: May 2020

Abstract

STUDY QUESTION
How is a women’s self-image affected by uterus transplantation (UTx)?

SUMMARY ANSWER
Women experienced receiving a uterus in both positive and negative ways, but in general, their self-image was positively affected; regardless of whether they have given birth to a child or not, recipients describe themselves as being ‘back to normal’ after the hysterectomy to remove the transplanted uterus.

WHAT IS KNOWN ALREADY
UTx has repeatedly proved to be a successful treatment for absolute uterine factor infertility. However, there has been no previous qualitative long-term research into the self-image of women undergoing UTx.

STUDY DESIGN, SIZE, DURATION
This complete, prospective cohort study included the nine recipients of the first UTxs performed in Sweden mostly in 2013. Interviews took place in the 5 years following surgery.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Eight out of the nine recipients had congenital absence of the uterus, a characteristic of Mayer–Rokitansky–Küster–Hauser syndrome, and one recipient lacked a uterus after a radical hysterectomy due to cervical cancer. The mean age of participants was 31.5 years at inclusion and at this time they all lived in stable marital relationships. Post-transplantation, interviews were performed annually for 5 years, comprising a total of 43 interviews. The interview followed a semi-structured guide. All interviews (median duration of around 25 minutes) were recorded, transcribed verbatim and then analysed by thematic approach.

MAIN RESULTS AND THE ROLE OF CHANCE
The joys and frustrations of becoming a ‘complete’ woman are seen as a master theme, which influences the three underlying subthemes, a changed self-perception, a changed body and a changed sexuality. Each of these subthemes have three underlying categories.

LIMITATIONS, REASONS FOR CAUTION
The small sample size is a limitation.

WIDER IMPLICATIONS OF THE FINDINGS
The results provide information that will be helpful in pre-operative screening procedures and in the psychological support offered both to women who experienced successful and unsuccessful outcomes following UTx.

STUDY FUNDING/COMPETING INTEREST(S)
Funding was received from the Jane and Dan Olsson Foundation for Science; the Knut and Alice Wallenberg Foundation; an ALF grant from the Swedish state under an agreement between the government and the county councils; the Swedish Research Council; a Ferring Pharmaceuticals scholarship in memory of Robert Edwards; and the Iris Jonzén-Sandblom and Greta Jonzén Foundation. The authors have no competing interests.

TRIAL REGISTRATION NUMBER
NCT01844362.
Automatic detection of hand hygiene using computer vision technology
Authors: Singh Amit , Haque Albert , Alahi Alexandre , Yeung Serena , Guo Michelle , Glassman Jill R , Beninati William , Platchek Terry , Fei-Fei Li , Milstein Arnold 
Published: May 2020

Abstract

Objective
Hand hygiene is essential for preventing hospital-acquired infections but is difficult to accurately track. The gold-standard (human auditors) is insufficient for assessing true overall compliance. Computer vision technology has the ability to perform more accurate appraisals. Our primary objective was to evaluate if a computer vision algorithm could accurately observe hand hygiene dispenser use in images captured by depth sensors.

Materials and Methods
Sixteen depth sensors were installed on one hospital unit. Images were collected continuously from March to August 2017. Utilizing a convolutional neural network, a machine learning algorithm was trained to detect hand hygiene dispenser use in the images. The algorithm’s accuracy was then compared with simultaneous in-person observations of hand hygiene dispenser usage. Concordance rate between human observation and algorithm’s assessment was calculated. Ground truth was established by blinded annotation of the entire image set. Sensitivity and specificity were calculated for both human and machine-level observation.

Results
A concordance rate of 96.8% was observed between human and algorithm (kappa = 0.85). Concordance among the 3 independent auditors to establish ground truth was 95.4% (Fleiss’s kappa = 0.87). Sensitivity and specificity of the machine learning algorithm were 92.1% and 98.3%, respectively. Human observations showed sensitivity and specificity of 85.2% and 99.4%, respectively.

Conclusions
A computer vision algorithm was equivalent to human observation in detecting hand hygiene dispenser use. Computer vision monitoring has the potential to provide a more complete appraisal of hand hygiene activity in hospitals than the current gold-standard given its ability for continuous coverage of a unit in space and time.
Digestibility of amino acids, energy, and minerals in roasted full-fat soybean and expelled-extruded soybean meal fed to growing pigs without or with multienzyme supplement containing fiber-degrading enzymes, protease, and phytase
Authors: Kiarie Elijah G , Parenteau Ilona A , Zhu Cuilan , Ward Nelson E , Cowieson Aaron J 
Published: May 2020

Abstract
Indigestible fiber–protein–phytate complexes reduce the feeding value of soy products. We investigated the effects of multienzyme supplement (MES, Victus) on standardized ileal digestibility (SID) of amino acids (AA) and apparent total tract digestibility (ATTD) of energy and minerals in roasted full-fat soybean (FFSB) seeds and expelled-extruded soybean meal (SBM) fed to growing pigs. The crude protein (CP) was 33.4% and 42.8% dry matter (DM) in FFSB seeds and SBM, respectively and corresponding values for crude fat were 17.4% and 11.8% DM. Semi-purified diets with 50% of either FFSB seeds or SBM as the sole source of AA were prepared without or with MES supplying phytase, protease, xylanase, and β-glucanase at 2,200, 8,300, 400, and 100 U/kg of feed, respectively. Diets had TiO2 as an indigestible marker and the ratio of cornstarch to sucrose and corn oil was identical to calculate DE by the difference method. Eight ileal-cannulated barrows (22.1 ± 0.61 kg) were fed diets in a replicated 4 × 4 Latin square design to give eight replicates per diet. The period lasted for 9 d: 5 d for acclimation, 2 d for fecal, and 2 d for ileal digesta samples. There was no (P &gt; 0.05) interaction between soy type and MES or MES effect on SID of AA; SBM had higher (P &lt; 0.05) SID of CP, His, Leu, and Lys. There was no (P &gt; 0.05) interaction between soy type and MES on energy digestibility. The FFSB seeds had higher ATTD of gross energy (GE, 80.2% vs. 76.6%; P &lt; 0.01) than SBM. Pigs fed MES had higher (P &lt; 0.05) ATTD of DM (91.3% vs. 87.7 %), GE (87.5% vs. 82.4%), CP (86.4% vs. 82.9%), crude fat (70.6% vs. 54.9%), Ca (63.2% vs. 60.2%), and P (67.5% vs. 63.2%). In conclusions, differences on AA and energy digestibility in soy products could be linked to processing and compositional differences. Although MES had no effect on SID of AA, the effects on the utilization of minerals and energy demonstrated the value of fiber-degrading enzymes, protease, and phytase in improving the nutritive value of soy products independent of processing.
Separating Predicted Randomness from Residual Behavior
Authors: Apesteguia Jose , Ballester Miguel A 
Published: May 2020

AbstractWe propose a novel measure of goodness of fit for stochastic choice models, that is, the maximal fraction of data that can be reconciled with the model. The procedure is to separate the data into two parts: one generated by the best specification of the model and another representing residual behavior. We claim that the three elements involved in a separation are instrumental in understanding the data. We show how to apply our approach to any stochastic choice model and then study the case of four well-known models, each capturing a different notion of randomness. We illustrate our results with an experimental data set.
Development of an Observational Parental Scaffolding Measure for Youth with Spina Bifida
Authors: Winning Adrien M , Stiles-Shields Colleen , Driscoll Colleen F Bechtel , Ohanian Diana M , Crowe Autumn N , Holmbeck Grayson N 
Published: May 2020

Abstract

Objective
To examine the reliability and validity of a new observational measure of parental scaffolding, as well as the impact of parental scaffolding on academic and social outcomes among youth with spina bifida (SB).

Methods
As part of a larger study, 137 families of youth with SB participated in family interaction tasks and self-report questionnaires at the baseline assessment. Teachers also reported on youth’s academic independence and competence, as well as social skills. Guided by previous research and theoretical formulations, a rational approach to measure development was employed whereby maternal and paternal scaffolding composites were created using the Family Interaction Macro-coding System (Holmbeck, Zebracki, Johnson, Belvedere, & Hommeyer (2007). Parent-child interaction macro-coding manual. Unpublished coding system. Chicago: Loyola University Chicago).

Results
The scaffolding measure demonstrated acceptable interrater and scale reliabilities. Additionally, both the maternal and paternal scaffolding composites were significantly associated with scores from self-report questionnaires of parenting behaviors in the expected directions. Maternal scaffolding was positively associated with IQ, academic competence, academic independence, and social self-control in youth with SB, whereas paternal scaffolding was positively associated with social cooperation and social self-control. Differences in scaffolding emerged between mothers and fathers, as well as across demographic variables.

Conclusion
Initial findings support the use of the scaffolding measure. Future research should continue to examine the utility of this scaffolding measure in families of youth with SB.
Sleep Disturbances in Survivors of Pediatric Acute Lymphoblastic Leukemia and Their Siblings
Authors: Russell K Brooke , Merz Erin L , Reynolds Kathleen , Schulte Fiona , Tomfohr-Madsen Lianne 
Published: May 2020

Abstract

Objective
Sleep disturbances have been identified by patients with cancer as common and distressing; however, conflicting evidence about the prevalence of these outcomes exists for survivors of childhood cancers. Additionally, little is known about how the experience of cancer might impact survivor siblings’ sleep. The current study compared the sleep of survivors of acute lymphoblastic leukemia who were 2–7 years off therapy and their siblings to healthy control/sibling dyads.

Methods
Participants (survivors, n = 45; survivor siblings, n = 27; controls, n = 45; control siblings, n = 41; 58% male) aged 8–18 (m = 11.64) completed a 7-day sleep diary and seven consecutive days of actigraphy. Parents (n = 90) completed the Children’s Sleep Habits Questionnaire for each of their children.

Results
No between-group differences were found on measures of sleep diaries or actigraphy. Parents reported that survivor siblings had significantly poorer sleep habits than survivors or controls. For survivors, greater time off treatment and younger age at diagnosis were associated with less total sleep time, more wake after sleep onset, and decreased sleep efficiency via actigraphy.

Conclusion
Sleep across all groups was consistent and below national guidelines. Although the survivor group did not have poorer sleep compared to their siblings or matched controls, within the survivor group, those who were diagnosed at an earlier age and those who were further off treatment had more disrupted sleep. Parent reports suggested that survivor siblings may be at risk for sleep problems.
Duodenocolic fistula by nail ingestion in a child
Authors: Kassegne Iroukora , Kanassoua Kokou Kouliwa , Dossouvi Tamegnon , Amouzou Yawod Efoe-Ga , Sakiye Aboza , Adabra Komlan , Alassani Fousseni , Amavi Ayi Kossigan , Tchangai Boyodi , Mouzou Tabana Essohanam , Dosseh Ekoue David Joseph 
Published: May 2020

Abstract
Unintentional foreign body ingestion is common among children. Normally, these ingested foreign bodies pass spontaneously. Only few of them may lead to complications such as fistula, which requires surgical intervention. We are reporting a case of accidental construction nail ingestion in a 3-year-old male child, for 30 days, without any symptoms. Diagnosis of duodenocolic fistula by construction nail was made on clinical examination and abdominal radiography features. He underwent surgical intervention, with nail removal, dudenal and colic primary closure. The follow-up was uneventful. We recommend emergently retrieval of sharp-pointed and long-ingested foreign bodies like a construction nail. Conservative outpatient management by clinical observation is not appropriate for this kind of foreign bodies. It may lead to complications such as perforation and fistula.
Agreeing to disagree: structuring future capital investment provisions in joint ventures
Authors: Elliott Edgar , D’Costa Lois , Bamford James 
Published: May 2020

Abstract
Prior to entering into any joint venture agreement (JVA), dealmakers should be aware of the options available to resolve future investment disagreements. There are three broad capital investment structures commonly found in joint ventures: (i) standard passmark rules; (ii) non-consent/opt-out; and (iii) sole risk. Within each category, deal practitioners have numerous options to tailor capital investment structures. As much as possible, deal practitioners should contemplate the most likely areas of disagreement, and then tailor the capital investment structures appropriately to ensure that the joint ventures (JV) can manage capital investment decisions in an efficient, value-preserving way.
While it is impossible to establish a formula to determine which specific contractual structures will best accommodate future capital investments in a given JV, companies should weigh various factors to inform their position. We reviewed 40 JVAs to understand various capital investment mechanics and how they differ based on the nature of the venture and owner context. Our research found an extremely diverse array of creative structural work-arounds to address different owner appetites to make future capital investments.
The purpose of this article is to describe, illustrate and provide benchmarks on different mechanics and contractual terms found in joint venture agreements, and to offer guidance as to which future capital investment mechanics should be included in venture agreements.
SDSS-IV MaNGA: spatially resolved star formation in barred galaxies
Authors: Fraser-McKelvie Amelia , Aragón-Salamanca Alfonso , Merrifield Michael , Masters Karen , Nair Preethi , Emsellem Eric , Kraljic Katarina , Krishnarao Dhanesh , Andrews Brett H , Drory Niv , Neumann Justus 
Published: May 2020

ABSTRACT
Bars inhabit the majority of local-Universe disc galaxies and may be important drivers of galaxy evolution through the redistribution of gas and angular momentum within discs. We investigate the star formation and gas properties of bars in galaxies spanning a wide range of masses, environments, and star formation rates using the Mapping Nearby Galaxies at APO galaxy survey. Using a robustly defined sample of 684 barred galaxies, we find that fractional (or scaled) bar length correlates with the host’s offset from the star formation main sequence. Considering the morphology of the Hα emission we separate barred galaxies into different categories, including barred, ringed, and central configurations, together with Hα detected at the ends of a bar. We find that only low-mass galaxies host star formation along their bars, and that this is located predominantly at the leading edge of the bar itself. Our results are supported by recent simulations of massive galaxies, which show that the position of star formation within a bar is regulated by a combination of shear forces, turbulence, and gas flows. We conclude that the physical properties of a bar are mostly governed by the existing stellar mass of the host galaxy, but that they also play an important role in the galaxy’s ongoing star formation.
High-redshift JWST predictions from IllustrisTNG: II. Galaxy line and continuum spectral indices and dust attenuation curves
Authors: Shen Xuejian , Vogelsberger Mark , Nelson Dylan , Pillepich Annalisa , Tacchella Sandro , Marinacci Federico , Torrey Paul , Hernquist Lars , Springel Volker 
Published: May 2020

ABSTRACT
We present predictions for high redshift (z = 2−10) galaxy populations based on the IllustrisTNG simulation suite and a full Monte Carlo dust radiative transfer post-processing. Specifically, we discuss the H α and H β + $[\rm O \,{\small III}]$ luminosity functions up to z = 8. The predicted H β + $[\rm O \,{\small III}]$ luminosity functions are consistent with present observations at z ≲ 3 with ${\lesssim} 0.1\, {\rm dex}$ differences in luminosities. However, the predicted H α luminosity function is ${\sim }0.3\, {\rm dex}$ dimmer than the observed one at z ≃ 2. Furthermore, we explore continuum spectral indices, the Balmer break at 4000 Å; (D4000) and the UV continuum slope β. The median D4000 versus specific star formation rate relation predicted at z = 2 is in agreement with the local calibration despite a different distribution pattern of galaxies in this plane. In addition, we reproduce the observed AUV versus β relation and explore its dependence on galaxy stellar mass, providing an explanation for the observed complexity of this relation. We also find a deficiency in heavily attenuated, UV red galaxies in the simulations. Finally, we provide predictions for the dust attenuation curves of galaxies at z = 2−6 and investigate their dependence on galaxy colours and stellar masses. The attenuation curves are steeper in galaxies at higher redshifts, with bluer colours, or with lower stellar masses. We attribute these predicted trends to dust geometry. Overall, our results are consistent with present observations of high-redshift galaxies. Future James Webb Space Telecope observations will further test these predictions.
Characterizing brown dwarf companions with IRDIS long-slit spectroscopy: HD 1160 B and HD 19467 B
Authors: Mesa D , D’Orazi V , Vigan A , Kitzmann D , Heng K , Gratton R , Desidera S , Bonnefoy M , Lavie B , Maire A-L , Peretti S , Boccaletti A 
Published: May 2020

ABSTRACT
The determination of the fundamental properties (mass, separation, age, gravity, and atmospheric properties) of brown dwarf companions allows us to infer crucial informations on their formation and evolution mechanisms. Spectroscopy of substellar companions is available to date only for a limited number of objects (and mostly at very low resolution, R &lt; 50) because of technical limitations, i.e. contrast and angular resolution. We present medium resolution (R = 350), coronagraphic long-slit spectroscopic observations with SPHERE of two substellar companions, HD 1160 B and HD 19467 B. We found that HD 1160 B has a peculiar spectrum that cannot be fitted by spectra in current spectral libraries. A good fit is possible only considering separately the Y+J and the H spectral band. The spectral type is between M5 and M7. We also estimated a Teff of 2800–2900 K and a log g of 3.5–4.0 dex. The low surface gravity seems to favour young age (10–20 Myr) and low mass (∼20 MJup ) for this object. HD 19467 B is instead a fully evolved object with a Teff of ∼1000 K and log g of ∼5.0 dex. Its spectral type is T6 ± 1.
Venom Systems as Models for Studying the Origin and Regulation of Evolutionary Novelties
Authors: Zancolli Giulia , Casewell Nicholas R 
Published: May 2020

Abstract
A central goal in biology is to determine the ways in which evolution repeats itself. One of the most remarkable examples in nature of convergent evolutionary novelty is animal venom. Across diverse animal phyla, various specialized organs and anatomical structures have evolved from disparate developmental tissues to perform the same function, that is, produce and deliver a cocktail of potent molecules to subdue prey or predators. Venomous organisms therefore offer unique opportunities to investigate the evolutionary processes of convergence of key adaptive traits, and the molecular mechanisms underlying the emergence of novel genes, cells, and tissues. Indeed, some venomous species have already proven to be highly amenable as models for developmental studies, and recent work with venom gland organoids provides manipulatable systems for directly testing important evolutionary questions. Here, we provide a synthesis of the current knowledge that could serve as a starting point for the establishment of venom systems as new models for evolutionary and molecular biology. In particular, we highlight the potential of various venomous species for the study of cell differentiation and cell identity, and the regulatory dynamics of rapidly evolving, highly expressed, tissue-specific, gene paralogs. We hope that this review will encourage researchers to look beyond traditional study organisms and consider venom systems as useful tools to explore evolutionary novelties.
Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors
Authors: Wongthida Phonphimon , Schuelke Matthew R , Driscoll Christopher B , Kottke Timothy , Thompson Jill M , Tonne Jason , Stone Cathy , Huff Amanda L , Wetmore Cynthia , Davies James A , Parker Alan L , Evgin Laura , Vile Richard G 
Published: May 2020

Abstract

Background
Diffuse midline glioma, formerly DIPG (diffuse intrinsic pontine glioma), is the deadliest pediatric brainstem tumor with median survival of less than one year. Here, we investigated (i) whether direct delivery of adenovirus-expressing cluster of differentiation (CD)40 ligand (Ad-CD40L) to brainstem tumors would induce immune-mediated tumor clearance and (ii) if so, whether therapy would be associated with a manageable toxicity due to immune-mediated inflammation in the brainstem.

Methods
Syngeneic gliomas in the brainstems of immunocompetent mice were treated with Ad-CD40L and survival, toxicity, and immune profiles determined. A clinically translatable vector, whose replication would be tightly restricted to tumor cells, rAd-Δ24-CD40L, was tested in human patient–derived diffuse midline gliomas and immunocompetent models.

Results
Expression of Ad-CD40L restricted to brainstem gliomas by pre-infection induced complete rejection, associated with immune cell infiltration, of which CD4+ T cells were critical for therapy. Direct intratumoral injection of Ad-CD40L into established brainstem tumors improved survival and induced some complete cures but with some acute toxicity. RNA-sequencing analysis showed that Ad-CD40L therapy induced neuroinflammatory immune responses associated with interleukin (IL)-6, IL-1β, and tumor necrosis factor α. Therefore, to generate a vector whose replication, and transgene expression, would be tightly restricted to tumor cells, we constructed rAd-Δ24-CD40L, the backbone of which has already entered clinical trials for diffuse midline gliomas. Direct intratumoral injection of rAd-Δ24-CD40L, with systemic blockade of IL-6 and IL-1β, generated significant numbers of cures with readily manageable toxicity.

Conclusions
Virus-mediated delivery of CD40L has the potential to be effective in treating diffuse midline gliomas without obligatory neuroinflammation-associated toxicity.