bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: acute abdominal pain in a 37-year-old patient and the consequences for his family
Authors: Niemeyer Elisabeth , Mofid Hamid , Zornig Carsten , Burandt Eike-Christian , Stein Alexander , Block Andreas , Volk Alexander E. 
Published: May 2020

Abstract
Background
Hereditary diffuse gastric cancer is a rare condition that accounts for approximately 1–3% of all gastric cancer cases. Due to its rapid and invasive growth pattern, it is associated with a very poor prognosis. As a result, comprehensive genetic testing is imperative in patients who meet the current testing criteria in order to identify relatives at risk. This case report illustrates the substantial benefit of genetic testing in the family of a patient diagnosed with hereditary diffuse gastric cancer.

Case presentation
A 37-year-old patient was admitted to the emergency department with acute abdominal pain. Following explorative laparoscopy, locally advanced diffuse gastric cancer was diagnosed. The indication for genetic testing of CDH1 was given due to the patient’s young age. A germline mutation in CDH1 was identified in the index patient. As a result, several family members underwent genetic testing. The patient’s father, brother and one aunt were identified as carriers of the familial CDH1 mutation and subsequently received gastrectomy. In both the father and the aunt, histology of the surgical specimen revealed a diffuse growing adenocarcinoma after an unremarkable preoperative gastroscopy.

Conclusion
Awareness and recognition of a potential hereditary diffuse gastric cancer can provide a substantial health benefit not only for the patient but especially for affected family members.
Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report
Authors: Li Wei , Su Ze-Zhen , Kang Ji-Hui , Xie Xiao-Yan , Xie Xiao-Hua , Zhuang Bo-Wen 
Published: May 2020

Abstract
Background
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is an uncommon malignant bladder tumor, and the overall prognosis is poor. Contrast-enhanced ultrasound (CEUS) provides a new effective modality for tumor detection and diagnosis.

Case presentation
A 30-year-old man complained of repeated painless gross haematuria for half a month. Conventional ultrasound demonstrated a hypoechoic solitary lesion with hyperechoic margins measuring 3.4 × 3.1 cm in the anterior wall of the bladder. Superb microvascular imaging (SMI) showed a strong flow signal in the mass. CEUS revealed that the lesion was characterized by hyper-enhancement in the early phase and hypo-enhancement in the late phase. The entire bladder wall was disrupted by homogeneous hyper-enhanced tumor tissue on CEUS. Time-intensity curves (TICs) showed a rapid wash-in with a high maximum signal intensity (SI) and quick wash-out. Finally, partial cystectomy was performed and the pathological examination confirmed the diagnosis of LCNEC with invasion into the whole layer of the bladder wall.

Conclusion
This case suggested that CEUS was a valuable imaging method to detect and diagnose LCNEC in the bladder, and that CEUS can provide information related to the depth of wall invasion and the microvasculature.
A population-based survey to assess the association between cannabis and quality of life among colorectal cancer survivors
Authors: Calcaterra Susan L. , Burnett-Hartman Andrea N. , Powers J. David , Corley Douglas A. , McMullen Carmit M. , Pawloski Pamala A. , Feigelson Heather Spencer 
Published: May 2020

Abstract
Background
As more states legalize cannabis for medical and recreational use, people increasingly use cannabis to treat medical conditions and associated symptoms. The prevalence and utility of cannabis for cancer-related symptoms may be clarified by examining cannabis use among patients with a common cancer diagnosis. We aimed to determine the prevalence of cannabis use among colorectal cancer (CRC) survivors and its associations with quality of life (QoL) and cancer-related symptomatology.

Methods
A cross-sectional survey of patient-reported QoL outcomes and behaviors, including cannabis use, was conducted within the Patient Outcomes To Advance Learning network’s (PORTAL) CRC Cohort. The cohort included a population-based sample of healthcare system members ≥18 years old diagnosed with adenocarcinoma of the colon or rectum from 2010 through 2016. We assessed the association between cannabis use and QoL using the European Organization for Research and Treatment of Cancer QLQ-C30 summary score.

Results
Of the 1784 respondents, 293 (16.4%) reported cannabis use following CRC diagnosis. Current tobacco smokers were more likely to use cannabis compared to former or never tobacco smokers (adjusted odds ratio [aOR] 2.71, 95% confidence interval [CI] 1.56 to 4.70). Greater alcohol use (> 4 drinks per month versus ≤4 drinks per month) was associated with cannabis use (aOR 2.17, 95% CI 1.65 to 2.85). There was an association between cannabis use and cancer stage at diagnosis, with stage 3 or 4 CRC patients more likely to use cannabis than stage 1 or 2 CRC patients (aOR 1.68, 95% CI 1.25 to 2.25). After adjusting for demographics, medical comorbidities, stage and site of CRC diagnosis, and prescription opioid use, people who used cannabis had significantly lower QoL than people who did not use cannabis (difference of − 6.14, 95% CI − 8.07 to − 4.20).

Conclusion
Among CRC survivors, cannabis use was relatively common, associated with more advanced stages of disease, associated with tobacco and alcohol use, and not associated with better QoL. Clinicians should inquire about cannabis use among their patients and provide evidence-based recommendations for cancer-related symptoms.
The effect of improved housing on indoor mosquito density and exposure to malaria in the rural community of Minkoameyos, Centre Region of Cameroon
Authors: Nguela Rachel L. , Bigoga Jude D. , Armel Tedjou N. , Esther Tallah , Line Dongmo , Boris Njeambosay A. , Frederic Tchouine , Kazi Riksum , Williams Peter , Mbacham Wilfred F. , Leke Rose G. F. 
Published: May 2020

Abstract
Background
This study evaluated the effectiveness of improved housing on indoor residual mosquito density and exposure to infected Anophelines in Minkoameyos, a rural community in southern forested Cameroon.

Methods
Following the identification of housing factors affecting malaria prevalence in 2013, 218 houses were improved by screening the doors and windows, installing plywood ceilings on open eaves and closing holes on walls and doors. Monthly entomological surveys were conducted in a sample of 21 improved and 21 non-improved houses from November 2014 to October 2015. Mosquitoes sampled from night collections on human volunteers were identified morphologically and their parity status determined. Mosquito infectivity was verified through Plasmodium falciparum CSP ELISA and the average entomological inoculation rates determined. A Reduction Factor (RF), defined as the ratio of the values for mosquitoes collected outdoor to those collected indoor was calculated in improved houses (RFI) and non-improved houses (RFN). An Intervention Effect (IE = RFI/RFN) measured the true effect of the intervention. Chi square test was used to determine variable significance. The threshold for statistical significance was set at P < 0.05.

Results
A total of 1113 mosquitoes were collected comprising Anopheles sp (58.6%), Culex sp (36.4%), Aedes sp (2.5%), Mansonia sp (2.4%) and Coquillettidia sp (0.2%). Amongst the Anophelines were Anopheles gambiae sensu lato (s.l.) (95.2%), Anopheles funestus (2.9%), Anopheles ziemanni (0.2%), Anopheles brohieri (1.2%) and Anopheles paludis (0.5%). Anopheles gambiae sensu stricto (s.s.) was the only An. gambiae sibling species found. The intervention reduced the indoor Anopheles density by 1.8-fold (RFI = 3.99; RFN = 2.21; P = 0.001). The indoor density of parous Anopheles was reduced by 1.7-fold (RFI = 3.99; RFN = 2.21; P = 0.04) and that of infected Anopheles by 1.8-fold (RFI = 3.26; RFN = 1.78; P = 0.04). Indoor peak biting rates were observed between 02 a.m. to 04 a.m. in non-improved houses and from 02 a.m. to 06 a.m. in improved houses.

Conclusion
Housing improvement contributed to reducing indoor residual anopheline density and malaria transmission. This highlights the need for policy specialists to further evaluate and promote aspects of house design as a complementary control tool that could reduce indoor human–vector contact and malaria transmission in similar epidemiological settings.
Modeling and dynamic analysis of tuberculosis in mainland China from 1998 to 2017: the effect of DOTS strategy and further control
Authors: Liu Siyu , Bi Yingjie , Liu Yawen 
Published: May 2020

Abstract
Background
Tuberculosis (TB) is one of the most important health topics in the world. Directly observed treatment and short course chemotherapy (DOTS) strategy combines medicine care and modern health system firmly, and it has been carried out by World Health Organization (WHO) since 1997. In the struggle with TB, China has promoted the process of controlling the disease actively, and the full coverage of DOTS strategy has been reached around 2004. Mathematical modeling is a very useful tool to study the transmission of diseases. Understanding the impact of DOTS strategy on the control of TB is important for designing further prevention strategy.

Methods
We investigate the impact of control strategy on the transmission of TB in China by dynamic model. Then we discuss further control for TB aiming at developing new vaccine and improving treatment. The optimal control problem, minimizing the total number of infectious individuals with the lowest cost, is proposed and analyzed by Pontryagin’s maximum principle. Numerical simulations are provided to illustrate the theoretical results.

Results
Theoretical analysis for the epidemic model is given. Based on the data reported by National Bureau of Statistics of China (NBSC), the basic reproduction number of each stage is estimated and compared, and they are $\mathcal {R}_{0}^{1}=1.7885$R01=1.7885 and $\mathcal {R}_{0}^{2}=1.0741$R02=1.0741, respectively. Optimal control strategy for further control is designed and proved well. An intuitionistic comparison between the optimal control strategy and the current control strategy is given.

Conclusions
The diagnosis and treatment of TB in China have been promoted a lot and the $\mathcal {R}_{0}$R0 is reduced by the full coverage of DOTS strategy. However, the $\mathcal {R}_{0}$R0 in China is still greater than 1 now. The relationship between $\mathcal {R}_{0}$R0 and vaccination strategy is shown. Optimal strategy aiming at exposed and infected population is suggested for further control.
Raman and FT-IR Spectroscopy investigation the cellulose structural differences from bacteria Gluconacetobacter sucrofermentans during the different regimes of cultivation on a molasses media
Authors: Atykyan Nelli , Revin Victor , Shutova Vitalina 
Published: May 2020

AbstractRaman and Fourier Transform Infrared (FT-IR) spectroscopy was used for investigation of structural differences of bacterial celluloses (BC), obtained by cultivation native and immobilized cells of Gluconacetobacter sucrofermentans during static and dynamic regimes of cultivation on a molasses media. It was found that the Raman and FT-IR spectra could characterized the groups of the cellulose molecules. The culturing bacterial cellulose in the presence of results in an increase of crystalline and it increased during cultivated on a molasses media with the addition of 1.5% ethanol—75.62%. The degree of BC crystallinity increased during dynamic regime of cultivation is higher than under static regime one. The maximal BC content was observed when 0.5% ascorbic acid was added to the cultivation medium with molasses and native cells. It was found, the degree of BC crystallinity during static regime cultivation on a molasses medium with ethanol, increased significantly to 73.5%, and during dynamic regime—75.6%. So, in this study, the changes of the bacterial cellulose conformation of were revealed during bacterial cultivation in a medium containing molasses in various cultivation modes.
Fractional Ostrowski type inequalities for bounded functions
Authors: Erden Samet , Budak Hüseyin , Zeki Sarikaya Mehmet , Iftikhar Sabah , Kumam Poom 
Published: May 2020

AbstractWe first establish some results involving Riemann–Liouville fractional integrals for partially differentiable functions. Then we obtain some fractional Ostrowski type inequalities for functions in class of functions$L_{p}$Lp,$L_{\infty }$L∞and$L_{1}$L1, respectively. We also give some midpoint type inequalities as special cases of our main results.
Development of the Modified Yale Food Addiction Scale Version 2.0 summary version in a representative sample of Czech population
Authors: Pipová Helena , Kaščáková Natália , Fürstová Jana , Tavel Peter 
Published: May 2020

Abstract
Background
Food addiction receives attention because of its participation in the rising obesity prevalence that affects the quality of life. The Czech Republic’s prevalence of obesity belongs to the highest in Europe.

Methods
We used the nationally representative non-clinical sample of 1841 respondents (N = 1841; 48,8% of men and 51.2% of women). Participants filled the sociodemographic questionnaire, Czech version of mYFAS 2.0 and the Relationship Questionnaire (RQ) to test the hypothesis.

Results
Confirmatory Factor Analysis showed that the single-factor model of Czech version of mYFAS 2.0 had adequate fit indices (χ2 (55) = 9670.8, p <  0.001; CFI, TLI > 0.95; SRMR < 0.07; and RMSEA < 0.08). The sample reliability in our research corresponded to Cronbach’s α = 0.89 (95% CI 0.88–0.90). The youngest population (aged 15–19) had a significantly higher score of mYFAS 2.0, than the older age groups. People living alone scored significantly higher than the married respondents. The middle-income groups scored significantly lower in mYFAS 2.0 than the lowest income group. Occasional (social) smokers showed a higher mYFAS 2.0 score in comparison with non-smokers. A difference regarding attachment styles has also been revealed, respondents characterized by insecure attachment styles showed a higher YFAS score.

Conclusion
The findings reinforce future work on the Czech version of mYFAS 2.0, including validation and using mYFAS 2.0 to explore food addiction and its related variables and attachment styles in the Czech environment.
A systematic review regarding women’s emotional and psychological experiences of high-risk pregnancies
Authors: Isaacs Nazeema Zainura , Andipatin Michelle Glenda 
Published: May 2020

AbstractBackgroundHigh-risk pregnancy refers to a pregnancy that negatively affects the health of the mother, the baby, or both. High-risk pregnancy evokes a range of emotional and psychological experiences for the expectant mother, and can adversely affect both the mother and the baby’s health. Medical research on high-risk pregnancy abounds, while women’s emotional/psychological experiences are not sufficiently documented, and hence much less attention and/or programming is directed to support women with high risk pregnancies.MethodsThe aim of this review is to present published evidence of how studies reported on the emotional and psychological experiences of a woman’s high-risk pregnancy journey. The systematic review examined qualitative studies over a 10 year period that were published between January 2006 and June 2017. These studies were identified on 10 databases. The study utilised three stages of review (i.e. abstract reading, title reading, and full-text reading) and for a successful conduction of the meta-synthesis, this study applied one of the phases provided by Noblit and Hare.ResultsThe findings provide empirical evidence that women’s emotional and psychological experiences (i.e. shock, fear, frustration, grief, isolation and loneliness, anger, sadness, guilt, and mental health disorder) are evident throughout their high-risk pregnancies experience.
Dentoskeletal effects of the maxillary splint headgear in the early correction of Class II malocclusion
Authors: Miguel José Augusto M. , Masucci Caterina , Fernandes Luciana Quintanilha Pires , Artese Flavia , Franchi Lorenzo , Giuntini Veronica 
Published: May 2020

Abstract
Background
To compare dentoskeletal changes produced by the maxillary splint headgear and cervical headgear appliance during the early phase of Class II treatment, specially the initial overjet and upper incisors position.

Subjects and methods
In this retrospective study, 28 Class II patients treated with the maxillary splint headgear (MSG, mean age 10.1 ± 1.9 years) and 28 Class II patients treated with cervical headgear (CHG, mean age 9.5 ± 1.9 years) were evaluated before and after treatment. Statistical comparisons between the two groups for cephalometric measurements at T1 and for T2-T1 changes were performed by means of independent sample t tests.

Results
The MSG showed a significantly greater reduction of the overjet in comparison to the CHG (− 2.4 mm and − 0.7 mm, respectively) and a significantly greater maxillary incisor uprighting (− 1.8 mm and 0.4 mm, respectively). In the MSG, overjet correction was due mainly to mandibular advancement (3.5 mm), while the correction of molar relationship (3.9 mm) was 64% skeletal and 36% dentoalveolar. In the CHG, the overjet correction was also more skeletal, due to mandibular growth (1.8 mm), while correction of molar relationship (3.5 mm) was 63% dentoalveolar and 37% skeletal.

Conclusions
Both groups showed favorable skeletal mandibular changes, which was more significant in the MSG. Regarding tooth movement, the maxillary splint headgear was more effective in uprighting upper incisors and reducing the overjet than cervical headgear appliance.
Comparison of Mycoplasma hyopneumoniae and porcine circovirus 2 commercial vaccines efficacy when applied separate or combined under experimental conditions
Authors: Sibila M. , Guevara G. , Cuadrado R. , Pleguezuelos P. , Pérez D. , Pérez de Rozas A. , Huerta E. , Llorens A. , Valero O. , Pérez M. , López C. , Krejci R. , Segalés J. 
Published: May 2020

Abstract
Background
Mycoplasma hyopneumoniae (Mhyo) and Porcine circovirus 2 (PCV-2) are two of the most significant infectious agents causing economic losses in the weaning to slaughter period. Due to their similar vaccination age, the objective of this study was to assess the efficacy of two already existing Mhyo (Hyogen®) and PCV-2 (Circovac®) vaccines when administered separately or combined (RTM) by means of Mhyo or PCV-2 experimental challenges.

Results
Seven groups of animals were included in the study, being three of them challenged with PCV-2, three with Mhyo and one composed of non-challenged, non-vaccinated pigs. Within each experimental challenge, non-vaccinated (NV) groups were compared with double vaccinated groups using the commercial products separated (VS) or combined (VC). Both vaccinated groups showed significant differences for most parameters measured regarding PCV-2 (serology, percentage of infected animals and viral load in tissues) and Mhyo (serology and gross lesions) when compared to NV groups. VS and VC offered similar results, being only significantly different the PCV-2 antibody values at different time points (higher in the VS group) of the study, although not at the termination day (21 days post-PCV-2 inoculation).

Conclusion
The present study expands the knowledge on the possibility of using two separate Mhyo and PCV-2 commercial vaccines as a RTM product, which offered equivalent virological, immunological and pathological outcomes as compared to these vaccines when used by separate.
Applications of radiomics in precision diagnosis, prognostication and treatment planning of head and neck squamous cell carcinomas
Authors: Haider Stefan P. , Burtness Barbara , Yarbrough Wendell G. , Payabvash Seyedmehdi 
Published: May 2020

AbstractRecent advancements in computational power, machine learning, and artificial intelligence technology have enabled automated evaluation of medical images to generate quantitative diagnostic and prognostic biomarkers. Such objective biomarkers are readily available and have the potential to improve personalized treatment, precision medicine, and patient selection for clinical trials. In this article, we explore the merits of the most recent addition to the “-omics” concept for the broader field of head and neck cancer – “Radiomics”. This review discusses radiomics studies focused on (molecular) characterization, classification, prognostication and treatment guidance for head and neck squamous cell carcinomas (HNSCC). We review the underlying hypothesis, general concept and typical workflow of radiomic analysis, and elaborate on current and future challenges to be addressed before routine clinical application.
Effect of carvedilol on premature ventricular complexes originating from the ventricular outflow tract
Authors: Hwang Jongmin , Lee Kyoungmin , Han Seongwook , Bae Han-Joon , Choi Sang Woong , Lee Cheol Hyun , Kim In-Cheol , Cho Yun-Kyeong , Park Hyoung-Seob , Yoon Hyuck-Jun , Kim Hyungseop , Nam Chang-Wook , Hur Seung-Ho 
Published: May 2020

Abstract
Background
Carvedilol is one of the most effective beta-blockers in reducing ventricular tachyarrhythmias and mortality in patients with heart failure. One of the possible antiarrhythmic mechanisms of carvedilol is the suppression of store overload-induced Ca2+ release, especially for the triggered activity.

Objectives
Premature ventricular complex (PVC) originating from the ventricular outflow tract (OT) is the most common form of idiopathic PVC, and its main mechanism is related to triggered activity. We evaluate the efficacy of carvedilol to suppress the OT PVC.

Methods
The electronic medical records at our hospital were screened to identify OT PVC patients treated with carvedilol. Clinical, electrocardiographic, and Holter monitoring studies were reviewed.

Results
A total of 25 patients who underwent Holter monitoring before and after carvedilol administration were found and enrolled. The mean age of the patients was 54.9 ± 13.9 years, and the mean dose of carvedilol was 18.2 ± 10.2 mg (sustained release formulation, 8/16/32 mg). The 24-h burden of PVC in 18 (72%) of 25 patients was significantly reduced from 12.2 ± 9.7% to 4.4 ± 6.7% (P = 0.006). In seven patients, the burden of PVC was changed from 7.1 ± 6.1% to 9.8 ± 8.4% (P = 0.061). There was no difference in age, carvedilol dose, duration of treatment, ventricular function, and left atrial size between responding and non-responding groups.

Conclusion
In this retrospective pilot study, treatment with carvedilol showed PVC suppression in 72% of patients. Now, we are conducting a prospective, randomized, multicenter study to evaluate the effect of carvedilol on OT PVC (Clinical trial registration: FOREVER trial, Clinical-Trials.gov: NCT03587558).