bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ojeada crítica al Diccionario de la lengua española de 2014
Authors: Trujillo Carreño Ramón , Portilla Durand Luisa 
Published: February 2020

En octubre de 2014 se publicó la 23.ª edición del Diccionario de la lengua española (DLE), texto en el cual era deesperar que se enmendasen aspectos cuestionables hallados en la 22.ª edición (2001). Nuestro interés al redactar el presente artículo es formular algunas reflexiones en relación con aspectos que requieren ser analizados. Consideramos preocupante queen la vigesimotercera edición del Diccionario se encuentren aún definiciones discutibles («que se deben discutir»), ya sea por la presencia de contorno (información innecesaria como parte de la definición), por las cadenas sinonímicas,por las entradas dobles que manifiestan un matiz sexista, por la ausencia de marca diatópica (acepciones desconocidas), por las formas definitorias (hiperónimos) disímiles o por el tratamiento erróneo de preposiciones, siglas y acrónimos.
Barriers and facilitators to the effective de-escalation of conflict behaviours in forensic high-secure settings: A qualitative study
Authors: Goodman Helena Mary , Brooks Cat Papastavrou , Price Owen , Barley Elizabeth Alexandra 
Published: February 2020

Abstract
Background: Violent and aggressive incidents are common within mental health settings and are often managed using high-risk physical interventions such as restraint and seclusion. De-escalation is a first-line technique to manage conflict behaviours and prevent violence and aggression. There is limited research into the use of de-escalation in high-secure settings. This study investigated staff, patient and carer perspectives on the barriers and facilitators to using de-escalation for conflict behaviours.
Methods: Semi-structured individual interviews (n=12) and focus groups (n=3) were conducted with eight patients, four carers and twenty-five staff members in a high-secure hospital in England. Interviews and focus groups were informed by the theoretical domains framework and were digitally recorded, transcribed verbatim and analysed using framework analysis and the COM-B behaviour change model.
Results: Four themes and 15 sub-themes (barrier and facilitators) were identified. Themes related to capabilities (building relationships: knowing the patient and knowing yourself), opportunities (filling the void: challenges within the high-security environment; dynamic relationships) and motivation (keeping everyone safe). Strong staff-patient therapeutic relationships underpinned by trust, fairness, consistency and an awareness of the trauma-aggression link were considered key to successful de-escalation. Specific psychological and interpersonal skills including empathy, respect, reassurance, sincerity, genuine concern and validation of the patient perspective are needed to achieve this. Barriers related to the physical environment; organisational resources, practices and systems; staff traumatisation; hierarchical and punitive attitudes towards patient care, and an insufficient understanding of psychiatric diagnoses, especially personality disorder. It was apparent across themes that fear, which was experienced by both staff and patients, was a driver for many behaviours.
Conclusions: This work has identified organizational and behaviour change targets for interventions seeking to reduce violence and restrictive practices through the use of de-escalation in high-secure hospitals. The potential for, and occurrence of, violence in such settings is high and leads to fear in patients and staff. The different factors which promote fear in each group should be addressed in de-escalation training.
The impact of cataract surgery on vision-related quality of life for cataract patients in China: a prospective study
Authors: Tu changsen , Ni Ji , Xu Xu , Mima Zhuoma 
Published: February 2020

Abstract
Background: Cataract is one of the most common blinding eye diseases, and patients' psychological, life and social activities will be significantly affected. Thus, the aim of this study is to to assess the impact of cataract surgery on vision-related quality of life (VRQOL) in China’s poor areaTibet. Methods: This study was a prospective cohort study. Subjects were invited to complete a validated questionnaire before and three months after cataract surgery. The 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) was used to assess the Vision-related quality of life. Generalized linear estimating equation (GEE) analysis and descriptive analyses were performed to record change of VRQOL before and after surgery. Results: One hundred and twenty-two patients were included. Among the One hundred and twenty-two patients, one hundred and seventeen (94.26%) completed the follow-up assessment after surgery. The total VRQOL was significantly improved after cataract surgery (p <0.001). the item of stereopsis and Binocular contrast sensitivity were also related to changes in VRQOL. Conclusions: The majority of patients had significantly improved VRQOL after cataract surgery in Chinese population.
Engaging stakeholders to identify implementation strategies for a faith-based physical activity program
Authors: Haughton Jessica , Takemoto Michelle L. , Schneider Jennifer , Hooker Steven P. , Rabin Borsika , Brownson Ross C. , Arredondo Elva M. 
Published: February 2020

Abstract
Background Stakeholder engagement is critical to the acceleration of evidence-based interventions into community settings. Harnessing the knowledge and opinions of community stakeholders increases the likelihood of successful implementation, scale up, and sustainment of evidence-based interventions. Faith in Action ( Fe en Acción ) is an evidence-based promotora -led physical activity program designed to increase moderate-to-vigorous physical activity among churchgoing Latina women. Methods We conducted in-depth interviews using a semi-structured interview guide based on the Consolidated Framework for Implementation Research (CFIR) at various Catholic and Protestant churches with large Latino membership in San Diego County, California to explore barriers and facilitators to implementation of a Faith in Action and to identify promising implementation strategies for program scale-up and dissemination. We interviewed 22 pastors and church staff and analyzed transcripts using an iterative-deductive team approach. Results Stakeholders described barriers and facilitators to implementation within three domains of CFIR: characteristics of individuals (lack of self-efficacy for and knowledge of PA; influence on churchgoers’ behaviors), inner setting (church culture and norms, alignment with mission and values, competing priorities, lack of resources), and outer setting (need for buy-in from senior leadership). From the interviews, we identified four promising implementation strategies for the scale-up of faith-based health promotion programs: 1) health behavior change training for pastors and staff; 2) tailored messaging; 3) developing community collaborations; and 4) gaining denominational support. Conclusions While churches can serve as valuable partners in health promotion, specific barriers and facilitators to implementation must be recognized and understood. Addressing these barriers through targeted implementation strategies at the adopter and organizational level can facilitate improved program implementation and lead the way for scale-up and dissemination.
The new AqE gene studied in non-tetrapoda vertebrates is high conserved
Authors: Puzakova Lyudmila V. , Puzakov Mikhail V. , Gostyukhina Olga L. 
Published: February 2020

Abstract
Background: The AqE gene encoding the NAD(P)H-dependent LDH2/MDH2 oxidoreductase has been described in living organisms predominantly in the aquatic environment. It was shown that the gene is present in bacteria and archaea. In the plant kingdom this gene is present only in algae. Animals have the AqE gene in all groups, from protozoa to fish. In the ancestor of tetrapods, the gene disappears and, accordingly, is absent in amphibians, reptiles, birds and mammals. It was suggested that the gene is involved in anaerobic respiration. The loss of the AqE gene in animals and plants is likely to be associated with living on land and the corresponding restructuring of their metabolic pathways, due to oxygen saturation and the absence of natural hypoxia as in aquatic organisms
Results: A study of the distribution of the AqE gene among non-tetrapoda vertebrates showed that it is present in the genomes of bony and cartilaginous fishes, as well as in the genomes of hagfishes and lampreys. In addition, it was reliably shown that, for representatives of Cypriniformes, the AqE gene was lost, and for representatives of Salmoniformes, it underwent significant deletions, which most likely led to its pseudogenization.
Conclusions: In most orders of non-tetrapoda vertebrates, the AqE gene remains highly conserved. This suggests that the AqE in aquatic vertebrates is an essential gene and undergoes to rigorous selection. AqE gene has the highest homology with the archaeal ComC that encoding SLDH. Based on the similarity of substrates, it cannot be excluded that the enzyme encoded by the AqE gene is involved in the malate-aspartate shuttle mechanism or biosynthesis of energy coenzyme M equivalent.
Application of ultrasound and magnetic resonance imaging in diagnosis of extra-abdominal desmoid-type fibromatosis
Authors: Li Wei , Fan Bing-Hui , Guo Zhi-Ying , Wang Zong-Bo , jia yanbo 
Published: February 2020

Abstract
Objective : To investigate the imaging characteristics of ultrasound and magnetic resonance imaging in extra-abdominal desmoid-type fibromatosis. Methods : Ultrasonic images of 58 patients with extra-abdominal desmoid-type fibromatosis and MRI images of 59 patients with extra-abdominal desmoid-type fibromatosis were analyzed retrospectively. The imaging characteristics of the two methods in the diagnosis of extra-abdominal desmoid-type fibromatosis were analyzed. Results : Among the 58 patients detected by ultrasound, obvious strong cord-like, columnar, and flocculent echoes were seen in 50 patients; blood flow signal was abundant in 37 patients. Among the 59 patients detected by MRI, fat-suppressed sequence scanning mainly presented high signal intensities. Spot-like and cordlike low signal intensities could be seen in lesions. Enhancement was obvious in 59 patients. In 58 patients detected by ultrasound, preoperative tumor diameter (4.46 ± 1.95) cm was shorter than the postoperative pathological result (6.33 ± 1.32) cm ( P < 0.05). In 59 patients detected by MRI, no significant difference in tumor diameter was detectable between preoperative (6.17 ± 0.98) cm and postoperative (6.32± 0.77) cm results ( P > 0.05). Conclusion : Ultrasound can reveal the fiber composition of desmoid-type fibromatosis well. MRI has certain advantages in diagnosing the true size and invasion range of desmoid-type fibromatosis, and can provide imaging reference for preoperative and postoperative evaluation.
Nomogram predicted overall survival of patients with neuroendocrine carcinoma of the breast
Authors: Tian Wenwen , Xie Xinhua , Kong Yanan , Liu Peng , Tan Weige , Xie Xiaoming 
Published: February 2020

Abstract
Background For primary neuroendocrine carcinoma of breast was a very rare subtype in breast cancers, its prognosis was still controversial and there was no independent standard for its treatment. The purpose of our retrospective study was to construct a nomogram to predict the overall survival (OS) of patients with neuroendocrine carcinoma of the breast. Methods 150 patients of training cohort were collected from Surveillance, Epidemiology, and End Results (SEER) database diagnosed between 2003 and 2015, and 93 patients of verification cohort were enrolled from Sun Yat-sen University Cancer Center (Guangzhou, China) diagnosed between 2004 and 2018. The nomogram was constructed uniting three significantly risk factors of overall survival identified by univariate and multivariate analysis and then validated using receiver operating characteristic (ROC) curves for discrimination, calibration plots and the decision curves analysis (DCA). Results Age, N stage and PR status were closely and significantly related to overall survival in patients with breast neuroendocrine carcinoma. The C-index of nomogram in the training and verification cohorts are 0.775 (95% CI, 0.784 to 0.615) and 0.760 (95% CI, 0.705 to 0.800) respectively. Calibration plots of practical and predicted possibility for the nomogram demonstrated that the predictive 5-year overall survival rate was in accordance with the actual overall survival probability in both sets. Moreover, the decision curves (DCA) also expressed pretty clinical benefit of the nomogram across a range of high-risk threshold. Conclusion This novel population-based nomogram may help with treatment decisions in patients with neuroendocrine carcinoma of the breast (NEBC).
Potential diagnostic value of novel circular RNA hsa_circ_0060927 in human colorectal cancer
Authors: Sadeghi Hossein , Heiat Mohammad 
Published: February 2020

Abstract
Background CYP24A1 plays a role in strictly regulated vitamin D metabolism pathway and has been nominated as a prognostic biomarker for colorectal cancer (CRC). Increasing evidence suggests that circular RNAs (circRNAs) are involved in cancer initiation and progression; however, their diagnostic values in cancers as the new potential biomarkers are still not fully understood. Methods and Results In the present study, by using quantitative real-time polymerase chain reaction (qRT-PCR), we demonstrated that CYP24A1 and hsa_circ_0060927 were only transcribed in 33 and 25 out of 83 CRC tissues, respectively. In these samples, we demonstrated that CYP24A1 was up-regulated in both linear and circular forms ( P < 0.05). Furthermore, we showed that CYP24A1 and hsa_circ_0060927 transcription were induced after vitamin D treatment in HCT-116 and HT-29 colon cancer cell lines. Importantly, analysis of the ROC curve in expressed samples indicated that CYP24A1 and hsa_circ_0060927 could serve as the potential diagnostic markers of CRC, but due to the fact that these genes are not expressed in many samples, the diagnostic role of these genes could be rejected. Conclusion Taken together, for the first time, the results of our study illustrated the expression levels hsa_circ_0060927 in CRC; however, further studies are required to validate the present results.
Study on the germination of nano - TiO 2 synthetic seeds and the physiology of Dendrobium officinale regenerated plants
Authors: Guan Jiemin , Lai Xiaoping , Zhang Guifang , Li Shijie , Guan Jiexian , Li Baohua 
Published: February 2020

Abstract
Synthetic seed of biological technology has been suggested as an effective strategy to improve breeding. Nano-TiO2 is a photosemiconductor material widely used in life science and agriculture. Nano-TiO2 has been recently shown to improve photosynthetic function, promote plant growth and development，but the physiology mechanism is still unclear. The aim of the current study was to confirm whether or not nano-TiO2 synthetic seed has an effect on germination and physiology of Dendrobium officinale. Using D. officinale protocorm models, we demonstrate that appropriate nano-TiO2 leads to growth and development of germination seedlings, and improves the root activity, nitrate reductase activity and antioxidant system activity. Our data also provide a basis for the improvement of the preparation process and practical production of D. officinale synthetic seeds.
Proteomic Analysis of Medicinal Plant Calotropis Gigantea by In Silico Peptide Mass Fingerprinting
Authors: Rehman Saad Ur , Rizwan Muhammad , Khan Sajid , Mehmood Azhar , Munir Anum 
Published: February 2020

:
Medicinal plants are the basic source of medicinal compounds traditionally used for the
treatment of human diseases. Calotropis gigantea is a medicinal plant belonging to the family of
Apocynaceae in the plant kingdom and subfamily Asclepiadaceae usually bearing multiple medicinal
properties to cure a variety of diseases.

Background:
The Peptide Mass Fingerprinting (PMF) identifies the proteins from a reference protein database by comparing the amino acid sequence that is previously stored in a database and identified.

Method:
The calculation of insilico peptide masses is done through the ExPASy PeptideMass and these masses are used to identify the peptides from MASCOT online server. Anticancer probability is calculated from the iACP server, docking of active peptides is done by CABS-dock the server.

Objective:
The purpose of the study is to identify the peptides having anti-cancerous properties by
in silico peptide mass fingerprinting.

Results :
The anti-cancer peptides are identified with the MASCOT peptide mass fingerprinting
server, the identified peptides are screened and only the anti-cancer are selected. De-novo peptide
structure prediction is used for 3D structure prediction by PEP-FOLD 3 server. The docking results
confirm strong bonding with the interacting amino acids of the receptor protein of breast cancer
BRCA1 which shows the best peptide binding to the active chain, the human leukemia protein
docking with peptides shows the accurate binding.

Conclusion :
These peptides are stable and functional and are the best way for the treatment of cancer and many other deadly diseases.
DFT based Computational Methodology of IC50 Prediction
Authors: Bag Arijit 
Published: February 2020

Background:
IC50 is one of the most important parameters of a drug. But, it is very difficult
to predict this value of a new compound without experiment. There are only a few QSAR
based methods available for IC50 prediction, which is also highly dependable on a huge number of
known data. Thus, there is an immense demand for a sophisticated computational method of IC50
prediction in the field of in silico drug designing.

Objective:
Recently developed quantum computation based method of IC50 prediction by Bag and
Ghorai requires an affordable known data. In present research work, further development of this
method is carried out such that the requisite number of known data being minimal.

Methods:
To retrench the cardinal data span and shrink the effects of variant biological parameters
on the computed value of IC50, a relative approach of IC50 computation is pursued in the present
method. To predict an approximate value of IC50 of a small molecule, only the IC50 of a similar kind
of molecule is required for this method.

Results:
The present method of IC50 computation is tested for both organic and organometallic compounds
as HIV-1 capsid A inhibitor and cancer drugs. Computed results match very well with the
experiment.

Conclusion:
This method is easily applicable to both organic and organometallic compounds with
acceptable accuracy. Since this method requires only the dipole moments of an unknown compound
and the reference compound, IC50 based drug search is possible with this method. An algorithm is
proposed here for IC50 based drug search.
PCR Detection and Sequencing of Trichomonas vaginalis in Women with Suspected Vaginitis in Southwestern Iran
Authors: Rafiei Abdollah , Safaie Khatereh , Tavalla Mehdi , Najafian Mahin 
Published: February 2020

Introduction:
The human being is considered a natural host for Trichomonas vaginalis
(T. vaginalis), which causes trichomoniasis, the most frequent non-viral sexually transmitted infectious
disease in the world. The current study aimed to evaluate the prevalence and sequencing of T.
vaginalis in women with vaginitis.

Methods:
In the current research, 514 vaginal discharge samples were obtained from women with
vaginitis. The specimens were evaluated by the direct wet mount examination, Dorset culture medium,
and PCR technique. Primers were designed for the detection of TVK3/TVK7, TVA5/TVA6
genes specific for the identification of T. vaginalis. The PCR-positive samples were sequenced and
compared with the sequences registered in the GenBank database.

Results:
Among the collected samples, 30 (5.83%), 45 (8.75%), 90 (17.50%), and 62 (12.06%) cases
were positive for T. vaginalis when assayed by the direct wet mount examination, Dorset culture
medium, and PCR technique (TVK3/TVK7, TVA5/TVA6 genes), respectively. There was no significant
relationship between trichomoniasis and demographic characteristics of women, such as age,
occupational status, mode of delivery, number of deliveries, educational level, and contraceptive
methods (p˃0.05). The range of vaginal pH was between 5-7 in women with vaginitis, and there
was a significant statistical correlation between the pH values and the infection rate (p<0.05). The
PCR-positive samples had 100% sequence homology with the reference sequence in the GenBank
database (accession number L23861.1).

Conclusion:
This study confirmed a relatively high prevalence of T. vaginalis in the southwestern
region of Iran. According to our results, the PCR method, especially detecting TVK3/TVK7 genes,
was more sensitive than the direct wet mount examination and Dorset culture medium methods.
Different Treatment Modalities followed by Dental Practitioners for Ellis Class 2 Fracture – A Questionnaire-based Survey
Authors: Jose Jerry , P. Ajitha , Subbaiyan Haripriya 
Published: February 2020

Introduction:Dental trauma is one of the most commonly seen injuries involving teeth and surrounding structures. The frequent causes of dental trauma are usually falls, traffic accidents, fights and sports injuries. Rapid treatment can prevent long-term damage to the orofacial structures and save the teeth. Ellis class 2 fracture is classified as the involvement of enamel and dentin excluding pulp. Dental practitioners are used to treating Ellis class 2 fracture very often in their dental practice and is usually considered as a dilemma among dental practitioners for the different treatment modalities followed for treatment of Ellis class 2 fracture. A survey is done among dental practitioners to assess the different treatment modalities followed by them in the case of Ellis class 2 fracture.Materials and Methods:A survey was done among 380 dental practitioners in the Chennai region in which 360 dental practitioners responded. The survey was distributed through electronic media and other means of communication. The survey data was collected, analysed and interpreted.Results:The results suggested that about 90% of dental practitioners had adequate knowledge and attitude towards the management of dental traumatic injuries. However, the practical application of the different treatment modalities was seen to be varied among dental practitioners. Based on this survey it was clear that majority of the dental practitioners in Chennai have good knowledge, attitude but there was a lack of clinical practice regarding the different treatment modalities followed by general practitioners for Ellis class 2 fracture.Conclusion:The survey shows that dental practitioners have a sound knowledge, attitude, but the practical application of the various treatment modalities available was seen to vary among various dental practitioners for Ellis class 2 fracture.