bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Fold Structure on Heat Accumulation in Hot Dry Rocks
Authors: Leng Wenxiang , Hu Ming , Wang Yingchun 
Published: July 2020

Abstract
Hot dry rock resources as one of the most promising clean energy in the future, with large reserves, renewable and other advantages, since the 1970 s, many countries all over the world have explored and practiced a lot on the exploration and development of hot dry rock resources, however, few studied the heterogeneity of the rock and the underground geologic structures of hot dry rock resources influence domain enrichment regularity of heat transfer mechanism. Therefore, this article considered the thermal conductivity of rock anisotropy, and set up a horizontal stratum and a fold strata 2D geological model, through numerical simulation with the field rock samples indoor triaxial rock thermal conductivity test results, introducing the thermal conductivity of rock anisotropy index A = K vertical bedding/ K parallel bedding and analyze the underground geologic structures’ influence on heat transfer in the rock. The results show that the anisotropy of rock thermal conductivity has no influence on the heat transfer process in underground rock strata when the rock layer is horizontal, which can be regarded as one-dimensional multilayer wall heat transfer. Fold structure will influence the underground heat transfer direction, so it is not simply seen as a one-dimensional multilayer flat wall heat transfer process in numerical simulation. At the inclined interface of rock strata, "heat flow refraction" usually occurs, which further affects the direction of heat transfer. As a result, heat is concentrated in the syncline of the fold structure in the deep and anticline in the middle and deep layers, while the temperature distribution in the shallow layer is almost unaffected by the structure. The research results of this paper are of great significance to the delineation of the target area and the development and utilization of the hot dry rock resources.
An online survey to evaluate the awareness and acceptance of geothermal energy among an educated segment of the population in five European and American countries
Authors: Balzan-Alzate Daniel , López-Sánchez Jacqueline , Blessent Daniela , Raymond Jasmin , Dezayes Chrystel , Portela Juan Pablo , Restrepo Estefania Ramírez , Rendón David Moreno , Malo Michel , Goderniaux Pascal , Daniele Linda , Borgne Tanguy Le 
Published: July 2020

Abstract
Advances in new technologies and ensuring a sustainable and safe energy supply, put communities in a key position to achieve the transition from conventional to renewable resources, such as geothermal energy. Perception and acceptance have a high impact on the feasibility of energy projects amongst different audiences, which is an important aspect to analyze. For this reason, this study focuses on evaluating the level of awareness and acceptance of geothermal energy within an educated segment of the population in five European and American countries (Canada, Colombia, Chile, Belgium and France) facing different stages of geothermal development. This study was conducted through an online survey, which was targeted to post-secondary students and professionals. Some of the most significant conclusions are: 1) there is a high degree of awareness of geothermal energy among the respondents in Chile and Canada, an average level in Belgium and France, and a low one in Colombia; 2) there is a favorable acceptance of a geothermal project in each country, even when hydraulic stimulation is considered; 3) environmental aspects and community safety are the most important issues that must be addressed to support a pilot geothermal project.
Siglec10 as an Immunosuppressive and Tumorgenesis Signature for Prediction of Survival Prognosis in Gliomas
Authors: Feng Yanyan , Zhang Yuxiang , Wang Ting , Feng Yuyin , Wang Hesong , Yuan Kai 
Published: July 2020

Abstract
BackgroundGlioma is a type of tumor occurring in central nervous system. Specific factors mutations and molecular abnormalities are used to conduct glioma classification and clinical decision in recent decade. Siglec10 is a member of sialic acid binding immunoglobulin superfamily. MethodsWe analyzed the siglec10 expression in glioma patients with immunohistochemical (IHC) staining method and evaluated the survival prognosis. Bioinformatic datasets including TCGA and CGGA were used to validate the IHC results. Functional enrichment analysis including GO, KEGG, and GSEA were conducted to study the related mechanism of siglec10, either. ResultsHigh siglec10 expression had shorter survival prognosis than low siglec10 expression in patients especially with malignant gliomas. Bioinformatic datasets including TCGA and CGGA validated the IHC results and discovered the expression of siglec10 was higher in malignant subtype than benign subtype of gliomas. So, siglec10 contributes to the poor prognosis of gliomas. Furthermore, the related mechanisms of siglec10 in gliomas were investigated by functional enrichment analysis including GSEA, GO, and KEGG analysis. Siglec10 was correlated with inflammatory mediators, inflammatory cells, and inflammatory pathways in gliomas. ConclusionsSiglec10 might take part in the immune response in tumor microenvironment to induce the progression and metastasis of glioma. This study showed siglec10 was a biomarker in glioma and it might be the potential target of glioma immunotherapy in the future.
Prognostic Role of Preoperative C-Reactive Protein in Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy - An Updated Meta-Analysis
Authors: QIAN XIAOYUAN , QIAN CAN , ZHANG JIAQIAO , LU YUCHAO , WANG ZHIXIAN , WANG QING , XUN YANG , ZHOU PENG , YANG YUANYUAN , WANG SHAOGANG 
Published: July 2020

Abstract
Background: C-reactive protein (CRP) is an acute-phase protein that is mainly stimulated by the inflammation-associated cytokines and high concentrations of CRP have been detected in many tumors. Many studies have shown that there is a close correlation between CRP and the prognosis of upper urinary tract carcinoma (UTUC). However, the prognosis significance of CRP in UTUC is still controversial. Our study aims to perform an updated systematic review and meta-analysis to investigate the association between CRP and the prognostic value for UTUC undergoing radical nephroureterectomy (RNU).Methods: A comprehensive electronic database search, using PubMed, EMBASE, and Web of Science, was performed to identify relevant research articles published before April 2020. Strict inclusion and exclusion criteria were established to extract data. Newcastle-Ottawa Scale was used to assess the quality of all candidate studies. The pooled hazard ratios (HR) and 95% confidence intervals (CIs) for recurrence-free survival (RFS), cancer-specific survival (CCS), and overall survival (OS) were calculated to evaluate the intensity of association. And heterogeneity and publication bias were assessed. Moreover, to ensure the stability of the analysis results, a sensitivity analysis was tested. All data were analyzed by Stata 15.0 and Review Manager 5.3.Results: Thirteen studies including a total of 2801 patients were eligible for meta-analysis. Our results verified that elevated CRP predicted poorer FRS (pooled HR=1.38, 95%CIs：1.12-1.71, P=0.003), CCS (pooled HR=1.64, 95%CI：1.38-1.94, P<0.001), OS (pooled HR=1.35, 95%CIs: 1.03-1.79 ,P=0.03) in patients with UTUC after RNU. Besides, elevated CRP was overtly correlated with tumor pathological stage (T3/T4 vs. ≤T2: OR=3.40, 95% CIs 2.39-4.84, P<0.001), tumor grade ((1/2 vs. 3: OR=1.68, 95% CIs 1.24-2.28, P<0.001), lymph node involvement (LNI) (+ vs. -: OR=2.73, 95% CIs 1.80-4.14, P<0.001), lymphovascular invasion (LVI) (+ vs. -: OR=4.1, 95% CIs 2.26-7.44, P<0.001). And these results got after using sensitivity analysis were verified to be stable and reliable. Furthermore, Begg's test result (RFS: P=0.089, CCS: P=0.592, and OS: P=0.089) showed no significant publication bias in the procedure.Conclusion: Elevated CRP indicates a poor prognosis for patients with UTUC undergoing RNU. Elevated CRP plays a significant role in reasonable risk stratification and individualized treatment.
WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?
Authors: Elfarargy Mohamed Shawky , Ashmawy Ghada Al , Abu-Risha Sally , Khattab Haidy 
Published: July 2020

Abstract
Background: Neonatal jaundice is a common neonatal disease which had adverse effect in the neonates especially preterm neonates when the level of indirect bilirubin is high enough to pass the blood brain barrier causing bilirubin encephalopathy or kernicterus. Aim: The aim of this study is to investigate the value of zinc (Zn) supplementation in preterm neonates with jaundice and if it will be beneficial or not. Patients and methods: A prospective randomized clinical trial (RCT) study, identification number is TCTR20200504007, which was done at Tanta University Hospital (TUH) from July 2016 to March 2018 on 200 preterm neonates suffering from neonatal jaundice. The studied neonates were divided into 2 groups: group 1, which received Zn and phototherapy, and group 2, which received phototherapy only and did not take Zn. In the group 1, 100 preterm neonates with jaundice received Zn as 0.6 ml(cm3) of zinc origin/kg/day orally through oro/nasogastric tube divided into 2 doses (/12 hours) which is equal 1.2 mg elemental zinc/kg/day orally for 10 day. Results: There was no significant difference in serum bilirubin between the 2 groups in the 2nd, 4th and 6th day of admission while the serum bilirubin was significantly decreased in neonates who were treated by Zn and phototherapy in group 1, compared with neonates of group 2 who were treated with phototherapy only in the 8th , 9th and 10th day of admission where the p value was 0.045* ,0.027* and 0.004* respectively. Conclusion: Zn administration in jaundiced preterm neonates is beneficial in decreasing serum bilirubin. Recommendation: Zn supplementation for jaundiced preterm neonates.
Tinzaparin in Pregnancy, Cancer and Renal Impairment: A Systematic Review Focusing on Safety
Authors: Vathiotis Ioannis , Syrigos Nikolaos , Dimakakos Evangelos 
Published: July 2020

Abstract
Background: Low-molecular-weight heparins are approved for primary and secondary venous thromboembolism prevention. Tinzaparin (Innohep®) is the low-molecular-weight heparin with the highest average molecular weight. The purpose of this study is to provide an update regarding the safety profile of tinzaparin sodium, prescribed either as a prophylactic or as a therapeutic regimen for VTE, in pregnant women, cancer patients and individuals suffering from renal impairment. Methods: We identified clinical trials reporting safety outcomes for pregnant women, cancer patients and individuals with renal impairment receiving either prophylactic or therapeutic doses of tinzaparin. We extracted predefined, clinically relevant outcomes of patients on tinzaparin.Results: For pregnant women on tinzaparin bleeding rates ranged from 9.7% to 10.3%; reported rates of major bleeding events, allergic reactions and thrombocytopenia were low. No maternal deaths or neonatal hemorrhages were recorded. Prophylactic administration of tinzaparin also showed promising results in pregnant women with recurrent unexpected pregnancy loss. In patients with cancer bleeding rates fluctuated between 0.8% and 27%; there was a trend showing that patients on tinzaparin exhibited fewer bleeding events than those on vitamin K antagonists. Bioaccumulation of tinzaparin was not correlated with age, body weight or creatinine clearance. Therapeutic administration of tinzaparin did not produce significant increase in the rates of clinically relevant or major bleeding events in patients with renal impairment. Periodic administration of tinzaparin did not result in bioaccumulation and tinzaparin is safe and can be used without dose adjustment in patients with severe renal impairment and creatinine clearance < 20 ml/min.Conclusions: Tinzaparin represents a thoroughly studied and safe choice for special populations that are at increased risk for both thrombosis and bleeding. Tinzaparin is safe for pregnant women. Current literature supports the use of tinzaparin without dose adjustment in patients with renal impairment and creatinine clearance < 20ml/min.
The symbiotic capacity of rhizobium shapes root-associated microbiomes
Authors: Liu Yuanhui , Ma Bin , Chen Wenfeng , Schlaeppi Klaus , Erb Matthias , Stirling Erinne , Hu Lingfei , Wang Entao , Zhang Yunzeng , Zhao Kankan , Lu Zhijiang , Ye Shudi , Xu Jianming 
Published: July 2020

Abstract
Background: Root-microbiome interactions are of central importance for plant performance and yield. A distinctive feature of legumes in this context is that they engage in symbiosis with rhizobia, which are abundant in soils and include both symbiotic and non-symbiotic bacterial strains. If and how the capacity of rhizobia to form symbiosis modulates root-associated microbiomes are not well understood. Results: We address this question by inoculating soybean (Glycine max) plants with wild type (WT) or a noeI mutant of Bradyrhizobium diazoefficiens. The noeI mutant produces a defective Nod factor and is thus compromised in its ability to establish functional symbiosis. Compared to soybean plants inoculated with WT rhizobia, plants inoculated with the noeI mutant showed a significant decrease in nodulation and root-flavonoid exudation, and exhibited strong changes in microbiome assembly in the rhizosphere and the rhizoplane. NoeI mutant-inoculated roots exhibited reduced diversity, co-occurrence interactions and a substantial depletion of beneficial microbes on the roots. The effects of the noeI mutation were absent in soils without plants, demonstrating that they are plant dependent. Complementation experiments showed that flavonoid supplementation is sufficient to restore recruitment of beneficial microbes. Conclusion: The results illustrate that the capacity of a rhizobium to form microbial symbiosis dramatically alters root-associated microbiomes, most likely by changing root exudation patterns. The results of this study have important implications for our understanding of the evolution of plant-microbiome interactions in the context of plant-bacterial symbioses.
Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Integrating Analysis of Gene Expression Profile
Authors: Zhu Ya-zhen , Liu Yi , Liao Xi-wen , Mo Xian-wei , Lin Yuan , Tang Wei-zhong , Luo Shan-shan 
Published: July 2020

Abstract
Objective: We aimed to explore the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes in gastric cancer (GC).Methods: The RNA-sequencing (RNA-seq) expression data for 351 GC patients and other relevant clinical data was acquired from The Cancer Genome Atlas (TCGA). Survival analysis and a genome-wide gene set enrichment analysis (GSEA) were performed to define the underlying molecular value of the ADAMTS genes in GC development.Results: The Log rank test with both Cox regression and Kaplan–Meier survival analysis showed that ADAMTS6 expression profile correlated with the GC patients’ clinical outcome. Patients with a high expression of ADAMTS6 were associated with poor overall survival (OS). Comprehensive survival analysis of the ADAMTS genes suggests that ADAMTS6 might be an independent predictive factor for the OS in patients with GC. Besides, GSEA demonstrated that ADAMTS6 might be involved in multiple biological processes and pathways, such as the vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), tumor protein P53, c-Jun N-terminal kinase (JNK), cadherin (CDH1) or tumor necrosis factor (TNF) pathways.Conclusions: In summary, our study demonstrated that ADAMTS6 gene could be used as a potential molecular marker for GC prognosis.
Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review
Authors: song yanlin , Zhang Jing , Liu Yu , Ma Xuelei 
Published: July 2020

Abstract
Background: Glioma is the most common primary brain tumor with poor prognosis. Some studies have learned the prognostic role of tumor infiltrating lymphocytes (TILs) in gliomas. But conflict conclusions were drawn by these studies. In order to reach an agreement, we systematically performed a meta-analysis.Method: A systematic literature research was conducted on the Web of Science, EMBASE, PubMed, Cochrane Library and China National Knowledge Infrastructure. The eligible articles which met the inclusion criteria were included in our study. The clinical outcomes of included patients were defined as progression-free survival (PFS) and overall survival (OS). The basic characteristics and relevant data were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to evaluate the prognostic role of TILs in gliomas. Newcastle Ottawa Scale (NOS) was used to assess the quality of included studies.Results: Eight articles published from 2008 to 2019 were finally included in our study. And 25 studies were conducted in these articles. We assessed the prognostic role of TILs in gliomas by subgroup analysis according to the subtypes of TILs. The pooled HRs for OS revealed that high density of CD3+ and CD4+ TILs were related to the poor prognosis of gliomas (HR for CD3+ TILs=1.266; HR for CD4+ TILs= 2.128). The pooled HR for PFS indicated that only high density of FOXP3+ TILs were related to poor prognosis (HR=2.785; 95%CI=1.848, 4.197).Conclusion: High density of CD3+ and CD4+ TILs may be a potential candidate for predicting poor OS of gliomas while high density of FOXP3+ TILs may serve as a good biomarker for predicting poor PFS of gliomas.
Boron Sensitivity and Storage in Brassica Napus and Its Potential for Clubroot Management
Authors: Gossen Bruce D. , Wang Dongniu , McLean Andrew , Tu Jiangying , Lahlali Rachid , Karunakaran Chithra , Peng Gary , McDonald Mary Ruth 
Published: July 2020

Abstract
Clubroot [Plasmodiophora brassica] severity in canola (Brassica napus) can be suppressed by addition of boron (B), but excess B produces phytotoxicity. However, some lines of a closely related species, B. rapa, are relatively insensitive to high levels of B. Assessment of 150 accessions of B. napus and B. rapa treated with 0, 8 and 16 kg B ha-1 as disodium octaborate tetrahydrate (trade name Solubor) identified several lines that were relatively insensitive to high levels of B. In 2015, 88 lines were planted in a clubroot-infested plot in Ontario, Canada in a replicated split-plot design, where the subplot treatments were 8 kg ha-1 of B versus a non-treated control. Boron-insensitive lines generally had slightly lower clubroot severity than sensitive lines, even in the control with no added B. Application of B reduced clubroot slightly in the most sensitive lines, but produced a large and significant reduction in severity in the most insensitive lines. Assessment of five insensitive lines under controlled conditions supported the observation that application of B substantially reduced clubroot severity in insensitive lines. Comparison of two sensitive and two insensitive lines each of B. napus and B. rapa using Boron K-edge X-ray absorption near-edge structure (XANES) spectra from a synchrotron-based soft-X-ray beamline showed that some insensitive lines were able to extract B efficiently from a soil that contained very low levels of B. The spectra of sensitive and insensitive lines differed when additional B was applied, which demonstrated that the insensitive lines stored B (and other elements such as S and P) differently than the sensitive lines. Differences in the amount and type of storage likely affect the susceptibility to clubroot, and merits further study.
5 Gleason score-associated gene signatures serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma
Authors: Zhang Lingyu , Li Yu , Liu Weiwei , Wang Xuchu , Ping Ying , Wang Danhua , Cao Ying , Dai Yibei , Tao Zhihua 
Published: July 2020

Abstract
Background: Prostate cancer (PCa) recurrence leads to much higher mortality than those without recurring events. Early and accurate laboratory diagnosis is particularly important for early identification of patients at high risk of recurrence and to benefit from additional systemic intervention. This study aimed to develop efficient and accurate Prostate Cancer diagnostic and prognostic biomarkers for the identification of initial tumor new events. Methods: Gene Expression Omnibus (GEO) datasets and The Cancer Genome Atlas (TCGA) data portal were utilized to obtain differentially expressed genes (DEGs) and clinical trait information in PCa. WGCNA analysis obtained the most relevant clinical traits and genes enriched in several modules. Univariate Cox regression analysis and multivariate Cox proportional hazards (Cox-PH) model was employed to candidate gene signatures related to Disease-Free Interval (DFI). Internal and external cohort was utilized to test and validate the validity, accuracy, and clinical utility of prognostic models.Results: We constructed and optimized a valid and credible model for predicting patient outcomes, based on 5 Gleason score-associated gene signatures (ZNF695, CENPA, TROAP, BIRC5, KIF20A). Furthermore, ROC and Kaplan-Meier analysis revealed higher diagnostic efficiency for PCa and predictive effectiveness in tumor recurrence and metastasis. Calibration curve also revealed high prediction accuracy in internal TCGA cohort and external GEO cohort. The model was prognostically significant in the stratified cohort, including TNM classification and Gleason score, and was deemed to be an independent PCa prognostic factor, and superioring to other clinicopathological characteristics. On the other hand, we also measured the correlation between gene signatures’ expression and inflammation landscape. 5 gene signatures were significantly positively correlated with tumor purity and negatively correlated with the immersion levels of CD8+ T cells. Conclusions: Our study identified and validated 5 gene signatures as biomarkers for prostate cancer diagnosis, providing an assessment of DFI while predicting tumor progression, possibly providing novel theories for the treatment of prostate cancer.