bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis for sizing of the stand-alone solar photovoltaic thermal system for the residential house at Sultanpur
Authors: Singh Shweta , Singh Rakesh Kumar , Tiwari Gopal Nath 
Published: July 2020

Abstract
Background: In this article, the potential applications of the solar photovoltaic thermal system have been discussed. The increasing cost and rapid depletion of conventional energy, researchers are optimizing the use of solar energy in residential and commercial purposes—the scope of solar energy, providing an alternative for residential and commercial power requirements. The average power requirement of a residential house is calculated with the help of power ratings. Hourly, daily, and monthly power requirement is calculated for designing the optimum size of solar photo voltaic thermal.Results: A stand-alone solar photovoltaic thermal system has been designed. For the sizing of the solar photovoltaic thermal system, meteorological data are collected through Synergy Enviro and PVWatts Calculator. The mathematical calculation and simulation study has been performed to estimate the expected power generation from the PVT. The cash flow and payback period of PVT are calculated. The total cost of installation was rupees 114450/- and the payback period was 9 years approximately.Conclusions: The forecasted output of solar photovoltaic thermal has been calculated based on solar radiation value obtained from different sources. The significant finding of the present study are: The maximum and the minimum electrical load was approximately 7.7 kWh per day in summer and about 2.5 kWh per day in winter. The maximum and minimum solar radiation at the installed site was 7.08 kWh / m 2 / day and 3.32 kWh / m 2 / day. The maximum electrical power calculated by installed solar module is 2466 kWh per year.
CompLement C5 Antibodies for decreasing brain injury after aneurysmal Subarachnoid Hemorrhage (CLASH): study protocol for a randomized controlled phase II clinical trial
Authors: Koopman Inez , Rinkel Gabriel J.E. , Vergouwen Mervyn D.I. 
Published: July 2020

Abstract
BackgroundThe inflammatory response after aneurysmal subarachnoid hemorrhage (aSAH) has been associated with early brain injury, delayed cerebral ischemia, poor functional outcome, and case-fatality. In experimental SAH studies, complement C5 antibodies administered shortly after SAH reduce brain injury with approximately 40%. Complement component C5 may be a new therapeutic target to reduce brain injury and hereby improve outcome after aSAH. We aim to investigate the pharmacodynamic efficacy and safety of eculizumab (complement C5 antibody) in patients with aSAH.MethodsA randomized, controlled, open-label, phase II clinical trial with blinded outcome assessment. Eculizumab (1200 mg) is administered intravenously <12 hours, on day 3 and on day 7 after ictus. Patients in the intervention group receive prophylactic antibiotics for 4 weeks, and those with a central line or an external ventricular shunt and a positive fungal or yeast culture also receive prophylactic antifungal therapy for 4 weeks. The primary outcome is C5a concentration in cerebrospinal fluid (CSF) on day 3 after ictus. Secondary outcomes include the occurrence of adverse events, inflammatory parameters in blood and CSF, cerebral infarction on magnetic resonance imaging, and clinical- and cognitive outcomes. We aim to evaluate 26 patients with CSF assessments, 13 in the intervention group and 13 in the control group. To compensate for early case fatality and inability to obtain CSF, we will include 20 patients per group.DiscussionThe CLASH trial is the first trial to investigate the pharmacodynamic efficacy and safety of eculizumab in the early phase after aSAH.Trial registrationNetherlands Trial Register: NTR6752, https://www.trialregister.nl/trial/6579. Registered on 27 October 2017. European Clinical Trials Database: EudraCT 2017-004307-51.
Effect of COVID-19 Pandemic on Anxiety in Rheumatology Patients Taking Immunosuppressive Drugs
Authors: Duran Tugba Izci , Acikgoz Seyyid Bilal , Gurbuz Cemal , Ucar Aysegul , Yavuzbilge Gokhan , Ozgen Metin 
Published: July 2020

Abstract
Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a public health emergency that is causing international concern. Patients with medical comorbidities are more likely to be infected and have a worse prognosis. The purpose of this study was to determine the prevalence of anxiety due to COVID-19 pandemic in patients with rheumatic and musculoskeletal diseases (RMDs) who used immunosuppressive drugs during the initial stage of the COVID-19 pandemic and to identify the risk and protective factors that cause anxiety.Methods: A total of 145 patients with RMDs aged ≥18 years who used regular immunosuppressive drugs and 95 healthy controls were included in the study. An anonymous survey comprising questions regarding the COVID-19 pandemic was used, and the Beck anxiety inventory (BAI) was used to measure the anxiety levels of participants. Additional information was collected such as demographic data, current RMDs, immunosuppressive drugs used, information and concerns about COVID-19, and the source of information about COVID-19.Results: About 42.1% patients reported that the epidemic caused concern due to the drug they were using, and 33.8% rated their concerns as moderate and severe. The BAI scores of patients and healthy controls were 4 (0-52) and 3 (0-18) respectively. According to the BAI scores, 16.5% patients had moderate to severe anxiety symptoms; and comparison of the groups showed that the anxiety level of the patient group was significantly higher (38.6% vs. 18.9%, p=0.001). Female had more anxiety symptoms in both groups (p<0.005). In addition, anxiety was lower in patients with higher education levels (p=0.039).Conclusion: It should be ensured that patients in the high-risk group are not provided false information, the patients are individually informed, and they trust the treatment team. Providing online or smartphone-based psychoeducation and psychological interventions may be considered for these patients with high anxiety levels.
Risk factors for stillbirth and early neonatal death: A case-control study in tertiary hospitals in Addis Ababa, Ethiopia
Authors: Weldetensaye Eskinder Kebede , Kekulawala Melani 
Published: July 2020

Abstract
Background: Globally, Ethiopia is ranked seventh in the absolute number of stillbirths. Attempts to decrease this number have been obstructed by an inadequate understanding of the risk factors leading to stillbirth and early neonatal death in Ethiopia. This study was conducted in two tertiary hospitals in Addis Ababa, Ethiopia, to identify the risk factors for stillbirth and neonatal death in this setting.Methods: This case-control study was conducted between October 2016 and May 2017 at Tikur Anbessa Hospital (TAH) and Gandhi Memorial Hospital (GMH). All enrolled women who had a stillbirth or early neonatal death during this period were included as cases and a random sample of women delivering at the hospital was selected to enroll as controls for a 2:1 ratio of controls to cases. Data on potential risk factors were retrieved from medical records including health passports, delivery records, and treatment charts. Statistical differences in background and social characteristics of cases and controls were determined by t-test and chi-squared (or fisher’s exact test) for quantitative and categorical variables, respectively. Binary logistic regression analysis was completed to determine any associations between risk factors and stillbirth/early neonatal death.Results: During the study period, 366 women delivering at the hospitals were enrolled as cases and 711 women delivering at the hospitals were enrolled as controls. During the study period, hospital records indicated that the estimated stillbirth and neonatal death rates were 30.7 per 1000. Neonatal causes (43.4%) were the most common, followed by antepartum (32.5%) and intrapartum (24.5%). Risk factors for stillbirths and early neonatal death were maternal education (aOR 1.747, 95%CI 1.098-2.780), parity (aOR 1.114, 95%CI .058- 2.484), previous stillbirth (aOR 9.447, 95%CI 6.245-14.289), previous preterm birth (aOR 3.620, 95%CI 2.363-5.546), and previous child with congenital abnormality (aOR 2.190, 95% 1.228-3.905), and antepartum hemorrhage during pregnancy (aOR 3.273, 95% 1.523-7.031).Conclusion: Antepartum hemorrhaging is the only risk factor in our study amenable for direct intervention. Efforts should be maximized to improve patient education and antenatal and obstetric services, particularly for women who have a history of obstetric complications identified as risk factors.
Effect of Health Transformation Plan on the Public Hospitals Performance Indicators; a case study in Iran
Authors: Ranjbar Mohammad , Jafari Hassan , Baziyar Mohammad , Pakdaman Mohsen , Pirasteh Vahid 
Published: July 2020

Abstract
Introduction: Health systems need constant changes and reforms in their structure in order to adapt to changing conditions and meet the needs of society. One of the fundamental changes in the health system of Iran is the health transformation plan (HTP), the effects of which must be examined from different aspects. Therefore, the purpose of this study is to investigate the effect of HTP on the performance indicators of public hospitals in the context of Yazd. Methods: The present cross-sectional study was carried out in all public hospitals in Yazd. Six performance indicators were examined on a monthly basis and in two time periods of 12 months before and after the implementation of HTP. Data were analyzed using SPSS software program version 22, the paired T-test and the Interrupted Time Series model. Findings: The implementation of the health transformation plan did not have a significant effect on the bed rotation distance, average length of stay and the ratio of surgical operations to bed indicators (p> 0.05). However, it had a statistically significant effect on the level and trend of mortality and hospitalization rates (p <0.05). Moreover, the implementation of HTP had a significant effect on the level of the bed occupancy indicator (P <0.05), but did not have a significant effect on the trend of this indicator (p> 0.05).Conclusion: Based on the research findings, all the selected indicators changed to some extent after the implementation of HTP, which in a way showed the effect of this plan on the performance of hospitals. Therefore, the continuation of such a plan, provided that sustainable financial resources are planned and human and physical resources are organized properly, can be an important step towards achieving universal health coverage and increasing justice in access to services.
Assessment of Isokinetic Trunk Muscle Strength and its Association with Health- Related Quality of Life in Patients with Degenerative Spinal Deformity
Authors: Yang Sen , Chen Can , Du Shiyu , Tang Yong , Li Kai , Yu Xueke , Tan Jiulin , Zhang Chengmin , Rong Zhigang , Xu Jianzhong , Wu Wenjie , Luo Fei 
Published: July 2020

Abstract
Background: A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality of life (HQOL). This index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural deformity represents only one aspect for consideration, namely, the disability effect of DSD.We assessed the isokinetic strength of trunk muscle in patients with degenerative spinal deformity (DSD), and investigated its relationship with health-related quality of life (HQOL).Methods: In total, 38 patients with DSD (DSD group) and 32 healthy individuals (control group) were recruited. Both groups were homogeneous for age, weight, height and body mass index (BMI). Assessments were performed using the isokinetic dynamometer IsoMed-2000; trunk extensor, flexor strength and flexion/extension (F/E) ratios were explored concentrically at speeds of 30°, 60° and 120° per second. The grip strength of both hands was measured using a hand-held dynamometer. Visual analogue scale (VAS) scores, the Oswestry Disability Index (ODI), a Roland-Morris disability questionnaire (RDQ), and a 36-item Short Form Health Survey (SF-36) evaluated patient HQOL. Correlations between trunk strength and HQOL were analyzed.Results: When compared with the control group, the DSD group showed lower trunk extensor strength at three velocity movements, and higher F/E ratios at 60° and 120°/s (p < 0.05). Both groups exhibited similar trunk flexor strength and grip strength (p > 0.05). In DSD group，trunk extensor strength at 60°/s was negatively associated with ODI and RDQ (p < 0.05). A negative relationship between trunk flexor strength at 120°/s and ODI was also recorded (p < 0.05). In addition, trunk extensor strength at 60°/s and trunk flexor strength at 120°/s were positively correlated with physical functioning and role-physical scores according to the SF-36 (p < 0.05). Conclusions: We identified isolated trunk extensor myopathy in DSD, which causes an imbalance in trunk muscle strength. Isokinetic trunk extensor strength at 60°/s and trunk flexor strength at 120°/s can predict disability, and decrease physical HQOL in DSD patients.
Development and External Evaluation of Predictions Models for Mortality of COVID-19 Patients using Machine Learning Method
Authors: Li Simin , Lin Yulan , Zhu Tong , Fan Mengjie , Xu Shicheng , Qiu Weihao , Chen Can , Li Linfeng , Wang Yao , Yan Jun , Wong Justin , Naing Lin , Wang Minghuan , Qin Chuan , Song Jia , Xu Shabei , Liu Zheng 
Published: July 2020

Abstract
Background To develop and evaluate the prognostic machine-learning model for mortality in patients with coronavirus disease 2019 (COVID-19).Methods Clinical data of confirmed COVID-19 were retrospectively collected from Wuhan between 18th January and 29th March 2020. Gradient Boosting Decision Tree (GBDT), logistic regression (LR) model, and simplified LR with selected 5 features (LR-5) model were built to predict the mortality of COVID-19. 5-fold area under curve (AUC), accuracy, positive predictive value (PPV), and negative predictive value (NPV) were calculated and compared between models.Results A total of 2,924 patients were included in the final analysis, 257(8.8%) of whom died during hospitalization and 2,667 (91.2%) survived. There were 21(0.7%) mild cases, 2,051(70.1%) moderate case, 779(26.6%) severe cases, and 73(2.5%) critically severe cases of COVID-19 on admission. The overall 5-fold AUC was observed highest in GBDT model (0.941), followed by LR (0.928) and LR-5 (0.913). The diagnostic accuracy were 0.889 in GBDT, 0.868 in LR and 0.887 in LR-5. GBDT model also showed the highest sensitivity (0.899) and speciality (0.889). The NPV of all three models exceeded 97%, while the PPV were relatively low in all models, 0.381 for LR, 0.402 for LR-5 and 0.432 for GBDT. In subgroups analysis with severe cases only, GBDT model also performed the best with a accuracy of 0.799 and 5-fold AUC (0.918).Conclusion The finding revealed that mortality prediction performance of the GBDT was superior to the LR models in confirmed cases of COVID-19, regardless of disease severity.
Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual, and Performance Parameters
Authors: Prins Philip , D’Agostino Dominic P. , Rogers Christopher Q. , Ault Dana L. , Welton Gary L. , Jones Dalton W. , Henson Samuel R. , Rothfuss Tyler J. , Aiken Kylie G. , Hose Jantzen L. , England Emilia L. , Atwell Adam D. , Buxton Jeffrey D. , Koutnik Andrew P. 
Published: July 2020

Abstract
Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, HR, RPE, affect, RER, VO2, VCO2, and VE were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance.
Objectively Measured Physical Activity Patterns in Children With Overweight and (Morbid) Obesity Across Different Weight Categories, Age Groups and Gender; Baseline Data of a Multidisciplinary Tailored Intervention Program
Authors: Velde Gabrielle ten , Plasqui Guy , Dorenbos Elke , Winkens Bjorn , Vreugdenhil Anita 
Published: July 2020

Abstract
BackgroundReduced physical activity (PA) is associated with childhood obesity and is a target for intervention. This study aimed to assess objectively measured PA patterns in Dutch children across weight categories, age groups and gender at the start of a lifestyle intervention.Methods202 children with overweight and (morbid) obesity (55% girls, 12 ± 3y of age, BMI z-score + 3.15 ± 0.73), referred to the Centre for Overweight Adolescents and Children’s Healthcare (COACH, Maastricht UMC+) were included. Children were categorized as overweight, obese or morbidly obese according to their BMI z-score. PA was measured with the GT3X Actigraph accelerometer.ResultsPA levels in children with morbid obesity were higher compared to children with obesity, also after correction for age and gender (corrected difference (B) 118 counts per minute (cpm), p = .006). Sedentary behaviour (SB) was lower in children with morbid obesity compared to children with obesity (B -51 min/day, p = .018). Girls performed significantly less moderate to vigorous PA than boys (B -11 min/day, p < .001) and with increasing age, children performed less PA (B -46 cpm, p < .001) and SB increased (B 18 min/day, p < .001).ConclusionWeight category morbid obesity, lower age and male gender were positively associated with PA and negatively with SB. These findings highlight the need for tailored PA promotion.Trial registration: The trial is registered with Clinicaltrials.gov NCT02091544. Registration date: March, 19th, 2014. (https://clinicaltrials.gov/ct2/show/NCT02091544?term=NCT02091544&draw=2&rank=1)
Secondary pneumothorax as a potential marker of apatinib efficacy in osteosarcoma: a multicenter analysis
Authors: Tian Zhichao , Yang Yang , Gao Songtao , Zhao Yao , Wang Xiaofeng , Zhang Fan , Li PO , Yao Weitao 
Published: July 2020

Abstract
Background
Studies have shown that apatinib is effective for treatment of osteosarcoma. However, pneumothorax is a major adverse event associated with treatment of osteosarcoma with apatinib. This study was performed to investigate pneumothorax characteristics and association with clinical outcomes in patients with osteosarcoma treated with apatinib.
Methods
We retrospectively reviewed the medical records of osteosarcoma patients treated with apatinib between January 2016 and April 2020 at three institutions. We evaluated the prevalence, healing time, recurrence, severity, clinical management, and prognosis of pneumothorax in these patients.
Results
A total of 54 osteosarcoma patients who received apatinib treatment were enrolled in this study. Among them, 14 patients had pneumothorax. There were significant differences between the patients with and without pneumothorax with regard to the cavitating rate of lung metastases (92.86% vs 32.50%, respectively, p < 0.001), objective response rate (42.86% vs 10.00%, p = 0.013), disease control rate (85.71% vs 42.50%, p = 0.006), 4-month progression-free survival (PFS) rate (57.10% vs 20.00%, p < 0.001), and median PFS (5.65 months vs 2.90 months, p = 0.011).
Conclusions
Pneumothorax and cavitation in lung metastases may be effective prognostic markers for patients with osteosarcoma treated with apatinib.
Lead Exposure Induced Copper Clearance Disorder of Blood-CSF Barrier
Authors: He Bin , Wang Liyuan , Li Shuang , Cao Fuyuan , Wu Lei , Chen Song , Pang Shulan , Zhang Yanshu 
Published: July 2020

Abstract
Lead is a heavy metal commonly found in the environment with known neurotoxicity, hematological and other toxicities. It has been found that lead exposure can disturb partial metal regulatory function in the blood-CSF barrier (BCB). Copper, which play an important role in maintaining normal brain function, can accumulate in brain after lead exposure. The studies of Alzheimer's disease (AD) indicated that abnormal copper homeostasis in cerebrospinal fluid (CSF) may be involved in the pathogenesis. However, the mechanism of copper disturbance in the brain caused by lead is still unknown. This study was designed to investigate copper clearance by the BCB in central nervous system after lead exposure, with focus on copper transporter protein CTR1/ATP7A. Inductively coupled plasma mass spectrometry (ICP-MS) and principal component analysis (PCA) were used to identify the changes of heavy metal level in hippocampus and CSF after lead exposure. It was found that the change in copper level was most pronounced in the brain between 3 to 12 weeks post lead exposure. Ventriculo-cisternal (VC) perfusion in Sprague Dawley (SD) rat suggested that the ability of BCB to deliver copper from the CSF to blood was decreased after lead exposure. Confocal microscope showed evidence of the presence of excess copper in the choroid plexus cells leading to CTR1/ATP7A shifting toward the apical microvilli facing the CSF after lead exposure. Finally, transmission electron microscopy (TEM) was used for observation of the microstructure of choroid plexus showed altered mitochondrial morphology with decreased microvilli after lead exposure. Our data suggested that lead exposure may alter BCB cellular microscopic structure and its copper transport, clearance function that might further cause brain injury.