bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors that influence the level of fish consumption in Tabanan Regency, Bali Province
Authors: Widihastuti R , Arthatiani F Y 
Published: July 2020

AbstractFish is an important source of animal protein and unsaturated fatty acids needed for the development of children and to prevent several other diseases. The promotion of fish nutrition benefits (fish eating) has been carried out for more than 10 years by the local government and by the Ministry of Maritime Affairs and Fisheries through some activities. Specifically in Tabanan Regency, a fish-eating program targeting students and women of reproductive age has been developed in the area. Apart from these activities, no significant changes in fish consumption in the target group were observed and in 2017. Tabanan was ranked the second lowest in the Province of Bali for fish consumption, with a value of 15.25 kg/cap/year. In 2016, fish consumption by 17.46 kg/capita/year. Thus, fish consumption in 2017 has decreased by 2.21 kg/capita/year compared to 2016. However, considering that in 2019 macro data processing has not been carried out, this study will conduct micro data processing to determine the development of fish consumption in 2019 using representative respondents in Tabanan Regency. The purpose of this study was to determine the factors that influence the level of fish consumption in Tabanan Regency. The independent variable consisted of age, education, occupation, status, and income, and the dependent variable was fish consumption. analyzed using multiple linear regression. This study involved 31 respondents to fill out questionnaires and interviews, as well as interviews with key informants in the district. Primary data were obtained through a closed questionnaire that was used to distribute data collection in addition to secondary data obtained from marine and fisheries services, as well as from district food security services. The analysis shows that age is an independent variable that affects the level of fish consumption in Tabanan. The age factor that affects the level of fish consumption has the highest percentage of samples at the age of 45-49 years which is 58.1% and a significance value (P<0.05). To realize programs to increase fish consumption that are more supported by the community, it is recommended to involve family heads aged 45-49 in the process of educating the community. Besides having a productive age, they also have insights that can be used as a way to facilitate education to the community and family. Thus, the realization of stunting prevention and handling program can be more resolved.
Risk assessment on the vulnerability of freshwater aquaculture to climate change: a case study from West Java, Indonesia
Authors: Prakoso V A , Gustiano R , Kristanto A H , Veeran R R , Ravitu N 
Published: July 2020

Abstract
Since the beginning of 1970, aquaculture has already become an important sub-sector to provide job and protein supply that contributes to economic growth, especially ii developing countries. Over two decades, climate change disturbs crop production globally Therefore, relevant stakeholders should pay attention to the impacts of climate change on the parameters that influence aquaculture production. This paper aimed to assess the vulnerability of aquaculture to climate change impacts in West Java, Indonesia. The first stage of the research involved the selection of specific and proper indicators and then calculated to assess vulnerability of aquaculture to climate change. The assessment was applied to 11 major species in West Java using a simple, transparent, and repeatable methodology that was appropriate fo a range of different aquaculture systems and fish species. The second stage consisted of two key step analyses: literature-based review or ‘species profiling’ and risk scoring assessmen related to sensitivity and impact to the species based on the previous study to rank the species from higher to lower risk based on several attributes. From the analysis, the study focused on highlighting the impacts of climate change on several key attributes of aquaculture production from each species. The results indicated that the highest vulnerabilities were found on striped snakehead and giant gourami aquaculture, with tilapia and African catfish, were found at the lowest vulnerabilities. The impacts of climate change to freshwater aquaculture across majo: species in West Java, Indonesia mostly affected larval rearing, connectivity of grow-out to the natural environment, and diseases-related problems.
Molecular Genetic Landscape of Sclerosing Pneumocytomas
Authors: Boland Jennifer M , Lee Hee Eun , Barr Fritcher Emily G , Voss Jesse S , Jessen Erik , Davila Jaime I , Kipp Benjamin R , Graham Rondell P , Maleszewski Joseph J , Yi Eunhee S 
Published: July 2020

Abstract

Objectives
Sclerosing pneumocytomas are rare pulmonary neoplasms that are typically benign. However, rare patients experience progressive disease, and therapy targeting specific genetic underpinnings could be an attractive therapeutic option. Recent studies have found recurrent AKT 1 mutations in sclerosing pneumocytoma, but little is known about whether oncogenic fusion genes may also be present.

Methods
To better understand the genetic background, 10 sclerosing pneumocytomas were subjected to next-generation sequencing cancer mutation panel testing (n = 9) and/or RNA sequencing (n = 3). The patients were all women (average age, 47 years; range, 17-74 years).

Results
Eight patients had solitary sclerosing pneumocytomas, while one had two tumors, and one had many bilateral tumors. Recurrent mutations were noted in genes involved in the mTOR pathway, including AKT1, PIK3R1, and PTEN. AKT1 alterations were particularly common, present in 78%. No recurrent genetic fusions were identified. The patient in our study with multiple bilateral lesions was treated with the mammalian target of rapamycin (mTOR) inhibitor everolimus, with no objective radiographic evidence of treatment response after 4 months.

Conclusions
Our data further support that abnormal activation of the mTOR pathway is a consistent genetic event in sclerosing pneumocytoma. This warrants further exploration to determine if mTOR pathway inhibitors may be effective in patients with metastatic or recurrent disease.
DeepAtomicCharge: a new graph convolutional network-based architecture for accurate prediction of atomic charges
Authors: Wang Jike , Cao Dongsheng , Tang Cunchen , Xu Lei , He Qiaojun , Yang Bo , Chen Xi , Sun Huiyong , Hou Tingjun 
Published: July 2020

Abstract
Atomic charges play a very important role in drug-target recognition. However, computation of atomic charges with high-level quantum mechanics (QM) calculations is very time-consuming. A number of machine learning (ML)-based atomic charge prediction methods have been proposed to speed up the calculation of high-accuracy atomic charges in recent years. However, most of them used a set of predefined molecular properties, such as molecular fingerprints, for model construction, which is knowledge-dependent and may lead to biased predictions due to the representation preference of different molecular properties used for training. To solve the problem, we present a new architecture based on graph convolutional network (GCN) and develop a high-accuracy atomic charge prediction model named DeepAtomicCharge. The new GCN architecture is designed with only the atomic properties and the connection information between the atoms in molecules and can dynamically learn and convert molecules into appropriate atomic features without any prior knowledge of the molecules. Using the designed GCN architecture, substantial improvement is achieved for the prediction accuracy of atomic charges. The average root-mean-square error (RMSE) of DeepAtomicCharge is 0.0121 e, which is obviously more accurate than that (0.0180 e) reported by the previous benchmark study on the same two external test sets. Moreover, the new GCN architecture needs much lower storage space compared with other methods, and the predicted DDEC atomic charges can be efficiently used in large-scale structure-based drug design, thus opening a new avenue for high-performance atomic charge prediction and application.
Disease-modifying drugs can reduce disability progression in relapsing multiple sclerosis
Authors: Amato Maria Pia , Fonderico Mattia , Portaccio Emilio , Pastò Luisa , Razzolini Lorenzo , Prestipino Elio , Bellinvia Angelo , Tudisco Laura , Fratangelo Roberto , Comi Giancarlo , Patti Francesco , De Luca Giovanna , Brescia Morra Vincenzo , Cocco Eleonora , Pozzilli Carlo , Sola Patrizia , Bergamaschi Roberto , Salemi Giuseppe , Inglese Matilde , Millefiorini Enrico , Galgani Simonetta , Zaffaroni Mauro , Ghezzi Angelo , Salvetti Marco , Lus Giacomo , Florio Ciro , Totaro Rocco , Granella Franco , Vianello Marika , Gatto Maurizia , Di Battista Giancarlo , Aguglia Umberto , Logullo Francesco Ottavio , Simone Marta , Lucisano Giuseppe , Iaffaldano Pietro , Trojano Maria 
Published: July 2020

Abstract
An ever-expanding number of disease-modifying drugs for multiple sclerosis have become available in recent years, after demonstrating efficacy in clinical trials. In the real-world setting, however, disease-modifying drugs are prescribed in patient populations that differ from those included in pivotal studies, where extreme age patients are usually excluded or under-represented. In this multicentre, observational, retrospective Italian cohort study, we evaluated treatment exposure in three cohorts of patients with relapsing-remitting multiple sclerosis defined by age at onset: paediatric-onset (≤18 years), adult-onset (18–49 years) and late-onset multiple sclerosis (≥50 years). We included patients with a relapsing-remitting phenotype, ≥5 years follow-up, ≥3 Expanded Disability Status Scale (EDSS) evaluations and a first neurological evaluation within 3 years from the first demyelinating event. Multivariate Cox regression models (adjusted hazard ratio with 95% conﬁdence intervals) were used to assess the risk of reaching a first 12-month confirmed disability worsening and the risk of reaching a sustained EDSS of 4.0. The effect of disease-modifying drugs was assessed as quartiles of time exposure. We found that disease-modifying drugs reduced the risk of 12-month confirmed disability worsening, with a progressive risk reduction in different quartiles of exposure in paediatric-onset and adult-onset patients [adjusted hazard ratios in non-exposed versus exposed &gt;62% of the follow-up time: 8.0 (3.5–17.9) for paediatric-onset and 6.3 (4.9–8.0) for adult-onset, P &lt; 0.0001] showing a trend in late-onset patients [adjusted hazard ratio = 1.9 (0.9–4.1), P = 0.07]. These results were confirmed for a sustained EDSS score of 4.0. We also found that relapses were a risk factor for 12-month confirmed disability worsening in all three cohorts, and female sex exerted a protective role in the late-onset cohort. This study provides evidence that sustained exposure to disease-modifying drugs decreases the risk of disability accumulation, seemingly in a dose-dependent manner. It confirms that the effectiveness of disease-modifying drugs is lower in late-onset patients, although still detectable.
Socioeconomic factors in disability retirement due to mental disorders in Finland
Authors: Karolaakso Tino , Autio Reija , Näppilä Turkka , Nurmela Kirsti , Pirkola Sami 
Published: July 2020

Abstract

Background
Previous research has identified low socioeconomic status (SES) as an epidemiological risk factor for early retirement and disability pension (DP) due to mental disorders. This study aims to examine these associations in greater detail, with separate consideration of the risk factors for mood disorders (F30–39) and non-affective psychotic disorder (F20–29) DP.

Methods
In this case–control setting the subjects (N = 36 879) were all those granted DP due to a mental disorder for the first time between 2010 and 2015 in Finland. All the subjects were matched with three controls for their gender, age and hospital district (N = 94 388). Three measures of dimensions of SES were used: education, income and occupational status, as well as family type as a control factor. Differences between DP recipients and controls, and between diagnostic groups, were studied using calculated characteristics and conditional logistic regression models.

Results
DP recipients often lived alone and had low educational and income levels. These characteristics were more prominent in non-affective psychotic disorder than in mood disorder DP. In white-collar occupational groups, the risk of DP was greater compared with blue-collar workers. Students were associated with the highest level of risk for all mental and mood disorder DPs.

Conclusions
We found evidence of SES factors associating with mental disorder-related severe loss of working and studying ability in a disorder-specific way. Notably, white-collar workers had an increased risk of mental disorder DP. This could be related to the psychosocially demanding contemporary working life in non-manual work.
A public–private partnership for dialysis provision in Ethiopia: a model for high-cost care in low-resource settings
Authors: Paltiel Ora , Berhe Ephrem , Aberha Amanuel Haile , Tequare Mengistu Hagazi , Balabanova Dina 
Published: July 2020

Abstract
Our purpose was to explore whether private–public partnerships (PPPs) can serve as a model for access to high-cost care in low-resource settings by examining a unique PPP providing haemodialysis services in a remote setting, investigating challenges and enablers. The study setting is a 500-bed teaching hospital serving a catchment population of 8 million in Northern Ethiopia. Based on local data collection, observation and in-depth interviews, we identified the impetus for the PPP, described the partnership agreement, reported outcomes after 6 years of activity and examined challenges that have arisen since the programme’s inception, including funding sustainability. The PPP was established in 2013 based on a decision by local leadership that treatment of patients with acute kidney injury (AKI) is a necessity rather than a luxury. A private partner was sought who could ensure service delivery as well as a reliable supply of consumables. The hospital contributions included infrastructure, personnel and sharing of maintenance costs. The partnership has facilitated uninterrupted haemodialysis service to 101 patients with AKI and 202 with chronic kidney disease. The former (&gt;50% cured) were mainly supported by charitable donations procured by the hospital’s leadership, while the latter were self-funded. The local university and community contributed to the charity. Utilization has increased yearly. Funding and logistical issues remain. In conclusion, this PPP enabled access to previously unavailable lifesaving care in Northern Ethiopia and could serve as a model for potential scale-up for haemodialysis provision in particular, and more broadly, high-cost care in low-resource settings. An ethical commitment to provide the service, combined with ongoing administrative and community involvement has contributed to its sustained success. Lack of affordability for most patients requiring chronic haemodialysis and reliance on charitable donations for treatment of patients with AKI pose challenges to long-term sustainability.
On best constants in L2 approximation
Authors: Bressan Andrea , Floater Michael S , Sande Espen 
Published: July 2020

Abstract
In this paper we provide explicit upper and lower bounds on certain $L^2$$n$-widths, i.e., best constants in $L^2$ approximation. We further describe a numerical method to compute these $n$-widths approximately and prove that this method is superconvergent. Based on our numerical results we formulate a conjecture on the asymptotic behaviour of the $n$-widths. Finally, we describe how the numerical method can be used to compute the breakpoints of the optimal spline spaces of Melkman and Micchelli, which have recently received renewed attention in the field of isogeometric analysis.
Propagation characteristics of ultrasonic P-wave velocity in artificial jointed coal briquettes
Authors: Sun Xiaoyuan , Chen Gengyue , Li Jihui , Xu Xiaomeng , Fu Shuai , Xie Jianlin , Liang Lei 
Published: July 2020

AbstractAbundant engineering practice shows that coal and rock dynamic disasters often occur in fault zones; hence, the detection of faults in coal mines is important. As an essential branch of seismic tomographic application, research shows that ultrasonic P-wave velocity can detect mine faults and provide technical support for dynamic disaster prewarning systems. Traditional P-wave testing mostly takes rock or raw coal as the research object, which has some shortcomings in controllability, homogeneity and comparability. This paper compares the difference in ultrasonic P-wave propagation velocity in jointless and jointed briquettes through laboratory research, focuses on the effect of macro-joints on P-wave velocity and makes a preliminary theoretical analysis. The results show that: (i) the three-dimensional P-wave velocity throughout a jointless briquette specimen is similar, which reflects the high homogeneity of this medium and avoids the influence of the random distribution of primary bedding, joints and structural planes; (ii) the P-wave velocity in jointless and jointed briquettes is positively correlated with density and forming pressure, and is negatively correlated with the angle between the ultrasonic wave and the joint surface in a sample and (iii) when the P-wave encounters the macroscopic joint surface, it may reflect and refract, changing the propagation direction and inducing wave mode conversion. This study provides the necessary technical support and a theoretical guide to optimise acoustic property analysis of coal and rock as well as a field application for seismic tomography technology.
Friend or Foe? Orb-Weaver Spiders Inhabiting Ant–Acacias Capture Both Herbivorous Insects and Acacia Ant Alates
Authors: Ledin Anna E , Styrsky John D , Styrsky Jennifer Nesbitt 
Published: July 2020

AbstractThe orb-weaver spiders Eustala oblonga (Chickering) and Eustala illicita (O. Picard-Cambridge) (Araneae: Araneidae) inhabit the ant-defended acacias Vachellia melanocerus (Beurling) and Vachellia collinsii (Safford) (Fabales: Fabaceae), respectively, in Panama. These spiders do not capture patrolling Pseudomyrmex ants but exploit their plant-protection services to escape predation. What effect the spiders have on the ant-acacia mutualisms is unknown. They may provide an additional layer of plant defense by capturing flying herbivorous insects in their webs. Alternatively, the spiders may disrupt the ant–acacia mutualisms by capturing alate acacia ants during nuptial flights. We evaluated these two hypotheses by sampling insects flying through acacia foliage and by identifying prey remains in webs. The proportions of insects captured on sticky card traps and in webs varied with taxonomic order and ecological role. Herbivorous insects greatly outnumbered other groups captured on sticky cards and were captured in spiders’ webs in both acacia species but made up a minority of prey remains in webs. Instead, insect predators and parasitoids made up the majority of prey remains and were comprised primarily by alate ant mutualists of the host acacias. These results provide indirect support for both hypotheses and suggest that the spiders potentially both benefit and harm their host ant-acacia mutualisms. The net effect of spider exploitation, however, is unclear and is likely based on both the effectiveness of plant protection from herbivory provided by the spiders relative to that provided by acacia ants, as well as the overall proportion of the ant reproductive caste the spiders actually capture.
Urban Entomology Highlights From 2019 Help Create Integrated Pest Management Plans
Authors: Gordon Jennifer R 
Published: July 2020

Abstract
Urban insect pests such as ants, termites, cockroaches, and bed bugs are more than just nuisances; they often negatively impact structures, landscapes, animal health, commercial food production, food safety, and public health (mental, physical, and financial). Due to the tremendous burden these insects can inflict, researchers, manufacturers, and pest management professionals work to create solutions that effectively manage urban and structural pests. One solution that has proven useful in agriculture is the development of an integrated pest management (IPM) plan; i.e., a science-based approach to pest control that utilizes multiple tactics such as preventative tools, chemical control (sprays, fumigation, and baits), biological control, and exclusion. There are many permutations of urban IPM plans, but in general they consist of five components: 1) identifying the pest, 2) monitoring the pest, 3) developing an intervention plan (including prevention and control techniques), 4) implementing the program, and 5) recording and evaluating the results. The objectives of the current publication were to 1) highlight urban entomology research published in 2019 and 2) show how the results from these publications help pest management professionals create and implement IPM plans.
Introduction to the Special Issue: Addressing Health Disparities in Pediatric Psychology
Authors: Valrie Cecelia , Thurston Idia , Santos, Melissa 
Published: July 2020

AbstractThis introduction to the special issue on Addressing Health Disparities in Pediatric Psychology provides context for why this special issue is needed, reviews key findings of the accepted articles, and discusses future directions for advancing the field. This special issue, one of three on this topic area that has been put forth in the history of this journal, comes at a critical point in our world. This is a time when the COVID-19 pandemic is systematically infecting Black, Indigenous, and People of Color and when there has been increased attention to systemic racism and intersecting violence inherent in multiple systems, including the justice, health, and educational systems. Using Kilbourne et al. (2016) framework, this special issue focuses on Phase 2 and Phase 3 research. Rather than only identifying health disparities (Phase 1), this issue focuses on understanding mechanisms and translating such understanding into interventions and policy changes. The accepted articles span a wide gamut from obesity to autism to rural populations. Furthermore, the articles provide methods for advancing the field beyond simply noting that systematic differences exist toward strategies to address these inequities. We conclude this introduction by discussing next steps for future research, with hopes that it inspires the next generation to study issues of disparities and inequity in deeper, more meaningful, and impactful ways.