bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrimination between clinical significant and insignificant prostate cancer with Apparent diffusion coefficient – A systematic review and meta analysis
Authors: Meyer Hans-Jonas , Wienke Andreas , Surov Alexey 
Published: March 2020

Abstract
Background Multiparametric MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present analysis sought to compare ADC values of clinically insignificant with clinical significant PC based upon a large patient sample. Methods MEDLINE library and SCOPUS databases were screened for the associations between ADC and Gleason score in PC up to May 2019. The primary endpoint of the systematic review was the ADC value of PC groups according to Gleason score. In total 27 studies were suitable for the analysis and included into the present study. The included studies comprised a total of 1633 lesions. Results Clinically relevant PCs (Gleason score 7 and higher) were diagnosed in 1078 cases (66.0%) and insignificant PCs (Gleason score 5 and 6) in 555 cases (34.0%). The pooled mean ADC value of the clinically significant PC was 0.86x10-3 mm2/s [95% CI 0.83-0.90] and the pooled mean value of insignificant PC was 1.1 x10-3 mm2/s [95% CI 1.03-1.18]. Clinical significant PC showed lower ADC values compared to non-significant PC. The pooled ADC values of clinically insignificant PCs were no lower than 0.75 ×10-3 mm2/s. This value may be proposed as a threshold for distinguishing clinically significant from insignificant PCs. Conclusions We evaluated the published literature comparing clinical insignificant with clinically prostate cancer in regard of the Apparent diffusion coefficient values derived from magnetic resonance imaging. We identified that the clinically insignificant prostate cancer have lower ADC values than clinically significant, which may aid in tumor noninvasive tumor characterization in clinical routine.
Modeling and Forecasting the Macroeconomic Driver of Time-Varying Coffee Price Volatility in Ethiopia
Authors: Abebe Teshome Hailemeskel 
Published: March 2020

Abstract
Recently, modeling and forecasting of high frequency data (such as daily price) volatility using GARCH-MIDAS attracts the attention of many researchers. Thus, the objective of this study is to model and forecast the average daily coffee price volatility using GARCH-MIDAS model over the sample period from January 01, 2010 to June 30, 2019. The GARCH-MIDAS component model decomposes the conditional variance into short run component which follows a mean-reverting unit GARCH process and long run component which consider different frequency macroeconomic indicators (in this study GDP, interest rate, trade openness and money supply) via mixed interval data sampling (MIDAS) specification. Unit root test results show the return series are stationary at level, while macroeconomic variables are stationary at first difference except interest rate, which is stationary at level. From the result of estimated GARCH-MIDAS component model, all selected indicators are crucial in explaining the long-term component price volatility.The Conrad &Schienleregression based result shows the absence of model specification. Moreover, the estimated GARCH-MIDAS component model with money supply as a main driver is used for out-sample forecast. Finally, the DM test statistic used for comparing the forecasting performance of GARCH-MIDAS component model against the standard GARCH model.The result shows that multiplicative GARCH-MIDAS component model provide an explanation for stylized facts that cannot be captured by standard GARCH model.
Dual-Trigger Improves the Outcomes of in Vitro Fertilization Cycles in Older Patients with Diminished Ovarian Reserve: a retrospective cohort study
Authors: Chern Chyi-Uei , Li Ju-Yueh , Tsui Kuan-Hao , Wang Peng-Hui , Wen Zhi-Hong , Lin Li-Te 
Published: March 2020

Abstract
Background: Dual-trigger for final oocyte maturation has been applied on the women with poor ovarian response or diminished ovarian reserve. However, the results were controversial. The Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number (POSEIDON) stratification is a set of newly established criteria for low prognosis patients. The aim of this study was to examine the effectiveness of dual trigger for final oocyte maturation on the in vitro fertilization (IVF) outcomes of patients who fulfill the POSEIDON group 4 criteria.Methods: This retrospective cohort study investigated 384 cycles fulfilling the POSEIDON group 4 criteria. The patients underwent IVF treatment using the gonadotropin-releasing hormone (GnRH) antagonist protocol. The study group contained 194 cycles that received dual trigger (human chorionic gonadotropin [hCG] plus GnRH agonist) for final oocyte maturation. The control group included 114 cycles where final oocyte maturation was performed with only hCG. Baseline characteristics and cycle parameters, as well as IVF outcomes of both groups were compared.Results: Baseline characteristics were similar between the dual trigger group and the control group. In terms of IVF outcomes, the dual trigger group demonstrated significantly higher number of retrieved oocytes, metaphase II oocytes, fertilized oocytes, day-3 embryos, and top-quality day-3 embryos. A statistically significant improvement in clinical pregnancy rate and live birth rate was also observed in the dual trigger group. Regardless of whether the patients were aged < 40 or ≥ 40 years, those receiving dual trigger had increased numbers of oocytes retrieved, fertilized oocytes, day-3 embryos, top-quality day-3 embryos than those with hCG-only trigger. Clinical pregnancy rate and live birth rate were significantly increased in the < 40-year old group whilst not significantly increased in those ≥ 40 years.Conclusions: Our data suggests that dual trigger for final oocyte maturation might improve clinical pregnancy rates and live birth rates of IVF cycles in patients fulfilling the POSEIDON group 4 criteria.
High prevalence of t895 and t9364 spa types of methicillin-resistant Staphylococcus aureus in a tertiary-care hospital in México: Different lineages of Clonal Complex 5
Authors: Negrete-González C , Turrubiartes-Martínez E , Galicia-Cruz OG , Noyola DE , Martínez-Aguilar G , Pérez-González LF , González-Amaro R , Niño-Moreno P 
Published: March 2020

Abstract
BACKGROUND Staphylococcus aureus is a leading cause of broad-spectrum infections both, in the community and within the healthcare settings. The methicillin-resistant Staphylococcus aureus (MRSA) variant has became a global issue of public health. The aim of this study was to examine the clinical and molecular characteristics of Staphylococcus aureus isolates and to define the population structure and distribution of major MRSA clones present in a tertiary-care hospital in Mexico. RESULTS From April 2017 to April 2018, 191 isolates of Staphylococcus aureus were collected. The frequency of MRSA was 26.7%, these strains exhibited resistance to clindamycin (85.3%), erythromycin (86.2%), levofloxacin (80.3%), and ciprofloxacin (86.3%). The majority of MRSA strains harbored the SCCmec type II (39/51); the t895 (29/51) and t9364 (6/51) were the most common spa types in both, hospital-associated MRSA and community associated MRSA isolates. The clones ST5-MRSA-II-t895 (New York /Japan clone) and ST1011-MRSA-II-t9364 (New York /Japan-Mexican Variant clone) were the most frequent. Finally, different lineages of Clonal Complex 5 (90.6%) and Clonal Complex 8 (9.1%) were identified in this study. CONCLUSION Our study provides valuable information about the epidemiology of MRSA in a city of the central region of Mexico, and this is the first report on the association between the t895 and t9364 spa types and the ST5 and ST1011 lineages, respectively.
Effect of Deletion of Gene Cluster involved in Synthesis of Enterobacterial Common Antigen on Virulence and Immunogenicity of Live Attenuated Salmonella Vaccine when Delivering Heterologous Streptococcus pneumoniae Antigen rPspA
Authors: Liu Qing , Shen Xuegang , Bian Xiaoping , Kong Qingke 
Published: March 2020

Abstract
Background: Enterobacterial common antigen (ECA) is a family-specific surface antigen shared by all members of the Enterobacteriaceae family. Previous studies showed that the loss of ECA results in Salmonella attenuation, indicating its usefulness as a vaccine candidate for Salmonella infection, but no studies have shown whether the mutation resulting from the deletion of the ECA operon in conjunction with other mutations could be used as an antigen vehicle for heterologous protein antigen delivery.Results: In this study, we introduced a nonpolar, defined ECA operon deletion into wild-type S. Typhimurium χ3761 and an attenuated vaccine strain χ9241, obtaining two isogenic ECA operon mutants, namely, χ12357 and χ12358, respectively. A number of in vitro and in vivo properties of the mutants were analyzed. We found that the loss of ECA did not affect the growth, lipopolysaccharide (LPS) production and motility of S. Typhimurium wild type strain χ3761 and its attenuated vaccine strain χ9241 but significantly affected the virulence when administered orally to BALB/c mice. Furthermore, the effects of the ECA mutation on the immunogenicity of a recombinant S. Typhimurium vaccine strain χ9241 when delivering the pneumococcal antigen rPspA were determined. The result showed that the total anti-PspA IgG level of χ12358 (pYA4088) was slightly lower than that of χ9241 (pYA4088), but the protection rate was not compromised.Conclusions: ECA affects virulence and benefits the Th2 immunity of Salmonella Typhimurium, therefore, it is feasible to use a reversibly ECA mutant mode to design future Salmonella vaccine strains for heterologous protective antigens.
Rapid Rehabilitation Surgery Program In Perioperative Management Of Radical Cystectomy And Ileal Conduit Diversion
Authors: Chen Hualei , Zhuo Xiaoan , Che Xianping , Gu Jun 
Published: March 2020

Abstract
Background: To evaluate the clinical effect of rapid rehabilitation surgery in the perioperative period of radical resection of bladder cancer by using the comparison with traditional perioperative treatment scheme. Methods：In this study, 80 patients who underwent bladder cancer with bladder cancer from August 2010 to October 2017 were collected, and the rapid rehabilitation Surgical treatment program and traditional treatment plan were adopted respectively during perioperative period, and the hospitalization cost, first exhaust time and after operation were compared between the two groups of patients. Clinical indexes such as hospitalization time and the incidence of postoperative complications to evaluate the application of both in the perioperative period of the radical ileum bladder surgery for bladder cancer. Results：Both groups of patients were cured and discharged. Compared with the traditional control group, the first exhaust time of the patients in the rapid recovery group was significantly earlier (3.10±0.45 D vs 3.88±0.91d P<0.05), the hospitalization cost (4.80±0.56 million vs 5.62±0.76 million P<0.05), and the length of hospital stay (8.8 6±1.23 d vs 14.47±3.58d P<0.05). However, there was no significant difference in the number of complications between the two groups (6 vs P>0.05). Conclusions：It is safe and effective to have rapid rehabilitation surgery for the perioperative period of radical resection of bladder cancer, and the rapid rehabilitation Surgical treatment program has the advantage of shortening the length of hospital stay and reducing the cost of hospitalization compared with the traditional treatment plan, which is beneficial to the recovery of patients after operation.
Anti-proliferative activities of Byrsocarpus coccineus using ovarian cancer cell lines
Authors: Ukwade Caroline , Ebuehi Osaretin , Adisa Rashidat , Singh Santos , Singh Rajesh 
Published: March 2020

Abstract
Background: Ovarian cancer is one of the most lethal tumors of gynecologic malignancies, due to lack of early detection, and a high rate of metastasis. The standard treatment is surgery and cytotoxic chemotherapy, but due to its cost and side effects, medicinal plants are widely used in developing countries. Byrsocarpus coccineus plant preparation, has been administered to patients traditionally in the management of tumour in Nigeria. In this study, we investigated the anti-proliferative effects of B. coccineus ethanol leaf extract against OVCAR3 and SW626 ovarian cancer cell lines. After treatment of the two cell lines with the extracts, analyses were carried out to determine inhibition of proliferation and expression of cell cycle markers, pro-apoptotic and anti-apoptotic markers. Results: Results showed that B. coccineus ethanol leaf extract, significantly inhibited cell migration and colony formation in OVCAR3 and SW626 treated cells in a dose-dependent manner. Results also show that B. coccineus ethanol leaf extract modulated the expression of p53 gene, cell cycle progression, anti-apoptotic and pro-apoptotic genes. Conclusions: These results suggest that B. coccineus have anti-proliferative properties and could induce apoptosis. Further investigation will be carried out to isolate bioactive compounds for the treatment of ovarian cancer.
Oral intermittent Vitamin D substitution: Influence of pharmaceutical form and dosage frequency on medication adherence: A randomized clinical trial
Authors: Rothen Jean-Pierre , Rutishauser Jonas , Walter Philipp N , Hersberger Kurt E , Arnet Isabelle 
Published: March 2020

Abstract
Background: To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.Methods: A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 x 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value <50 nmol/l and age ≥18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels. Results: The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5 – 100.0%) than weekly (66.4 – 98.1 %) administration. Vitamin D levels increased significantly (p<0.001) in all participants. An optimal value of >75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants.Conclusions: Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of >75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.
Perceived Health and Stress among Primary Care visitors - a comparative cross-sectional study between Greece and Scandinavia
Authors: Koppner Jenny , Chatziarzenis Marios , Faresjö Tomas , Theodorsson Elvar , Thorsell Annika , Nilsson Staffan , Olsen Ole , Faresjö Åshild 
Published: March 2020

Abstract
Background: Health behavior varies highly across European countries, and stress and stress-related disorders are commonly seen in European Primary Health Care. Greece has suffered deeply from the 2008 international financial crisis, whereas Scandinavian countries were less affected. Several reports of increasing mental health issues and poorer perceived health among the Greek population have been published. Self-reported health and stress are established public health indicators. A novel physiological marker of long-term stress, cortisol in hair, is at hand and applied in this study. Here, our aim was to study perceived health, including mental health, and self-reported and biological stress in Greece compared to Scandinavia. Methods: A cross-sectional comparative study of adult (18-65) Primary Health Care visitors from semi-rural areas in Greece (n=84) and Scandinavia (n=140). Data collection encompassed a questionnaire with a variety of health and stress indicators and hair samples for analyzes of cortisol levels. Results: The Greek sample reported significantly poorer overall health (p<0.0001) than the Scandinavians and significantly higher perceived stress (p<0.0001). The Greeks were also less hopeful of the future (p<0.0001), and to a larger extent fulfilled the HAD criteria for depression (p<0.0001) and anxiety (p=0.002). There were no significant differences in cortisol levels between the study-groups. The strongest predictors explaining ill health in logistic regressions were being Greek (p=0.001) and feeling hopeless about the future p=0.001, OR= 6.00 (CI; 2.10-14.88). Strong predictors in logistic regressions for high perceived stress were anxiety: high (p=<0.0001) and medium, (p=0.0001), as well as medium depression (p=0.02). Participants with either low or high cortisol levels, and those that reported ill health, had elevated self-reports of high stress, but these did not reach statistical significance.Conclusions: The results suggest that Greek adult Primary Health Care visitors perceived their health more negatively than the Scandinavians, including a higher presence of depression, anxiety, and a lower hope for the future. The Greeks also reported higher perceived stress, not reflected in higher cortisol levels. These findings could be interpreted against the background of socio-cultural differences in northern and southern Europe, and might also reflect the economic crisis that the Greek population experienced at that time.
The impact of the stretching force of incision on early clinical results after primary total knee arthroplasty (TKA)
Authors: Gong Long , Yanlei Wang , Ping Yi , Yan Sun , Jipeng Song , Mingsheng Tan 
Published: March 2020

Abstract
Background：A variety of surgical approaches are used in primary total knee arthroplasty (TKA), including medial parapatellar, sub-vastus, mid-vastus, lateral, and less invasive techniques. Previous studies demonstrated that there existed widely varied degrees of anterior knee soft-tissue stretching in patients undergoing primary TKA. However, the impact of incision stretching on TKA’s results failed to be investigated.Methods：1210 patients accepted primary and unilateral TKA at the authors’ affiliated institutions between Jan. 2011 and Dec. 2015. We recorded and analyzed the following data, including each patient's characteristics, incision stretching index (IS index), perioperative information, and follow-up assessments. By trisecting the IS index, patients were grouped and compared about visual analogue scale (VAS) pain scores as the primary outcome, knee circumference, knee range of motion (ROM), sensory testing, and the strength of quadriceps. Results：1089 patients undergoing primary and unilateral TKA in our two institutions were screened for final analysis, and 121 ones were excluded. The mean IS index was 22.6 (range: 19.7-24.8). VAS pain score, knee circumference, ROM, area of abnormal sensation, and the strength of quadriceps among group IS A, IS B, and IS C were significantly different (P<0.05). With the increase in the IS index, VAS pain score, knee circumference, area of abnormal sensation, and incision problems were significantly increased (P<0.05), while ROM and the strength of quadriceps decreased (P<0.05). Also, no significant difference in PJI and deep vein thrombosis (DVT) among groups was observed (P>0.05). Conclusions： There was a significant impact of incision stretching on clinical outcomes after TKA. Decreased incision stretching, which mainly depended on the length in full extension of the knee, can improve postoperative pain relief, surgical swelling, ROM, sensory disturbance of the knee, and the strength of quadriceps with reduced risk of incision complications.
Straight stem and threaded cup total hip arthroplasty systems in patients under 60 years of age: outdated or still a benchmark? A report on a cohort of 75 patients after 28.8-30.2 years of follow-up
Authors: Pisecky Lorenz , Allerstorfer Jakob , Schauer Bernhard , Hipmair Günter , Hochgatterer Rainer , Böhler Nikolaus , Gotterbarm Tobias , Klotz Matthias 
Published: March 2020

Abstract
Purpose: The goal of this retrospective observational study of one cohort was to evaluate the long-term outcome in patients younger than 60 years after total hip arthroplasty using a straight uncemented stem and an uncemented threaded cup. Methods: Between 1986 and 1987, 75 hips of 75 patients (mean age: 53.35±6.17 years) were consecutively implanted with an Alloclassic Zweymüller/Alloclassic SL stem and an Alloclassic CSF cup. 44 patients had died over the last 30 years. The remaining 31 patients (mean age: 82.9±6.4years) were reinvited for follow-up examinations. Clinical and radiographic evaluations were carried out. Results: At a mean follow-up of 29.5 (28.8-30.2), 4 patients (5.3%) were lost to follow up. For the endpoint aseptic loosening (defined as the removal of stem or the cup for 2 cases), the overall survival rate is 97.3%. For the endpoint revision for any reason (22 patients), the survival rate is 70.6%. Eleven patients needed an exchange of head and liner due to wear. The mean time from implantation until change of head and liner was 21.44 years (SD 5.92). Other reasons for revisons were septic loosenings (3 cases), aseptic loosening of stem and cup (1 case), aseptic loosening of stem (1 case), periprosthetic calcification (2 cases), implant fracture (1 case), periprosthetic fracture (1 case), intraoperative fissure of stem (1 case), total wear of liner including cup (1 case). Conclusion: The combination of a straight stem (Alloclassic) and a screw cup (CSF) shows excellent results in young patients under the age of 60 at ultra-longterm follow up at 30 years. Revisions due to wear of the polyethylene liner are more likely than in the older patients.
Long-term survival after resection of pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: case report and review of literature
Authors: Tohyama Taiji , Sakamoto Katsunori , Tamura Kei , Nakamura Taro , Watanabe Jota , Wakisaka Hiroyuki , Takada Yasutsugu 
Published: March 2020

Abstract
Background: The most common sites of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been reported to be the liver, lung, bone, and adrenal glands, but there have also been many reports of cases of multiple recurrence. The prognosis after recurrence is poor, with reported median survival after recurrence of HCC ranging from 9 to 19 months. Here, we report a case of long-term survival after recurrence of pharyngeal metastasis following living-donor liver transplantation (LDLT) for HCC within the Milan criteria, by resection of the metastatic region and cervical lymph node dissection. Case presentation: A 47-year-old man with a Model End-stage Liver Disease (MELD) score of 11 underwent LDLT for HCC within the Milan criteria on liver cirrhosis associated with hepatitis B virus infection, with his 48-year-old elder brother as the living donor. One year and 10 months after liver transplantation, he visited a nearby hospital with a chief complaint of discomfort on swallowing. A pedunculated polyp was found in the hypopharynx, and biopsy revealed HCC metastasis. Pharyngeal polypectomy was performed, followed by neck lymph node dissection 2 years thereafter. Although recurrence subsequently occurred three times in the grafted liver, the patient is still alive 12 years 10 months after recurrence of pharyngeal metastasis. He is now a tumor-free outpatient taking sorafenib. Conclusion: It is necessary to recognize that the nasopharyngeal region is a potential site of HCC metastasis. Prognostic improvement can be expected with close follow-up, early detection, and multidisciplinary treatment including radical resection.