bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Binnenmarkt für Philanthropie - Programm für eine europäische Stiftungspolitik“
Authors: Oldenburg Felix , von Abendroth Max 
Published: February 2020

Zusammenfassung
Wenn eine deutsche gemeinnützige Stiftung ein griechisches Flüchtlingscamp mit Fördermitteln unterstützen möchte, bedeutet das in rechtlicher Hinsicht, Formen der Steuerbegünstigung unterschiedlicher Länder gleichzeitig zu managen. Das ist verbunden mit hohem administrativem Aufwand. Was fehlt, ist ein „Binnenmarkt für Philanthropie“. Dieser Beitrag befasst sich mit der Frage, warum ein europäischer Binnenmarkt für Philanthropie wichtig ist und was die europäische Stiftungswelt mit dem „European Philanthropy Manifesto“ (20. März 2019) fordert.
Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer
Authors: Singh Praveen , Kumari Munmun , Bal Amanjit , Srinivasan Radhika , Ghosh Sujata 
Published: February 2020

Abstract
The diagnostic and therapeutic potential of Maackia amurensis agglutinin (MAA) have been reported in various malignancies. Earlier, we have found that MAA specifically interacted with human non-small cell lung-cancer (NSCLC) cells and induced apoptosis in these cells. The present study was designed to identify M. amurensis leukoagglutinin (MAL-I, one of the components of MAA, having the same carbohydrate specificity as MAA) interacting membrane sialoglycoprotein(s) of two subtypes of human NSCLC cell lines. Nine proteins were identified using two-dimensional (2D)-polyacrylamide gel electrophoresis (PAGE) followed by MAL-I-overlay transblotting and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS). Among these proteins, HSP60 was selected for further characterization. The sialoglycoprotein nature of membrane-HSP60 of NSCLC cell lines was confirmed by its reduced reactivity with MAL-I in Western blots in the presence of GM2 and by dual staining of the cell lines with MAL-I and HSP60-antibody. These findings were further substantiated by enzymatic analysis of membrane-HSP60 as well as in-silico evidence regarding this protein. Our observations were validated by immunohistochemical analysis of both subtypes of NSCLC tissue sections. Membrane-HSP60 was found to be involved in the inhibition of MAL-I-induced morphological alteration of NSCLC cells and also in the proliferation and migration of these cells, indicating the probable role of sialylated membrane-HSP60 in this disease.
The Effect of Temperature Change on the Output Characteristics of a Solar Power Plant under Partial Shading Conditions
Authors: Kievets Anton , Bay Julius , Suvorov Aleksey , Askarov Alisher , Rudnik Vladimir 
Published: February 2020

AbstractCurrently, the world is widely introducing renewable energy sources including solar power plants (SPP). In order to predict their work, it is necessary to adequately simulate the processes occurring in solar panels, not only in standard conditions, but also in conditions of partial shading. At present, the effect of partial shadowing is considered from the point of view of changes in the luminous flux, however, for a more adequate and comprehensive simulation, it is also necessary to take into account the temperature change in the shaded areas of SPP, especially considering the area of powerful SPP, the temperature of individual sections of which can radically differ, which is undoubtedly will lead to a change in the output characteristics of the SPP. Failure to take this factor into account, when modeling high-power SPP leads to results that do not correspond to real data.
Observation of an exceptional point in a non-Hermitian metasurface
Authors: Park Sang Hyun , Lee Sung-Gyu , Baek Soojeong , Ha Taewoo , Lee Sanghyub , Min Bumki , Zhang Shuang , Lawrence Mark , Kim Teun-Teun 
Published: February 2020

Abstract
Exceptional points (EPs), also known as non-Hermitian degeneracies, have been observed in parity-time symmetric metasurfaces as parity-time symmetry breaking points. However, the parity-time symmetry condition puts constraints on the metasurface parameter space, excluding the full examination of unique properties that stem from an EP. Here, we thus design a general non-Hermitian metasurface with a unit cell containing two orthogonally oriented split-ring resonators (SRRs) with overlapping resonance but different scattering rates and radiation efficiencies. Such a design grants us full access to the parameter space around the EP. The parameter space around the EP is first examined by varying the incident radiation frequency and coupling between SRRs. We further demonstrate that the EP is also observable by varying the incident radiation frequency along with the incident angle. Through both methods, we validate the existence of an EP by observing unique level crossing behavior, eigenstate swapping under encirclement, and asymmetric transmission of circularly polarized light.
Crystal structure of bis[(μ2-4⋯O,O′:O′)-(4-hydroxybenzoato-κ2
O,O′)-(1,10-phenanthroline-κ2
N,N′)]-di-lead(II)μ-4-hydroxybenzoato-κ3
O,O′:O′;κ3
O,O′:O′-bis-[(4-hydroxybenzoato-κ2
O,O′)bis(1,10-phenanthroline-κ2
N,N′)di-lead(II)] monohydrate, C52H36N4O12Pb2 ⋅ H2O
Authors: Dai Ben-Cai , Liu Chang-Chun , Zhou Yang , Chen Jin , Fu Yang , Zhao Pei-Zheng 
Published: February 2020

Abstract
C52H36N4O12Pb2 ⋅ H2O, monoclinic, P21/n (no. 19), a = 13.7767(1) Å, b = 7.9925(1) Å, c = 21.2490(2) Å, β = 93.1490(10)°, V = 2336.20(4) Å3, Z = 4, R
gt(F) = 0.0220, wR
ref(F
2) = 0.0582, T = 170 K.
A bioinspired strategy for poly(3,4-ethylenedioxypyrrole) films with strong water adhesion
Authors: Sathanikan Ananya , Guittard Frédéric , Darmanin Thierry 
Published: February 2020

Abstract
Using a bioinspired approach, we prepare poly(3,4-ethylenedioxypyrrole) (PEDOP) films with parahydrophobic properties, characterized by high apparent water contact angle and strong water adhesion. The films are made by electropolymerization and the influence of substitution by an alkyl chain of various length (from C4H9 to C14H29) on the 3,4-ethylenedioxy-bridge is reported. More precisely, the best properties are obtained from a length of C12H25 due to the formation of spherical nanoparticles.
Öffentliche Investitionen: Die Schuldenbremse ist nicht das Problem
Authors: Feld Lars P. , Reuter Wolf Heinrich , Yeter Mustafa 
Published: February 2020

ZusammenfassungEs gibt öffentlichen Investitionsbedarf in Deutschland, zum Beispiel zur Bewältigung des Strukturwandels, im Rahmen der Klimapolitik oder mit Blick auf die öffentliche Infrastruktur. Die genaue Höhe dieses Bedarfs ist jedoch äußerst unsicher. Einer Erhöhung der Investitionen stehen die ausgelasteten Kapazitäten in der Bauwirtschaft und den Planungsämtern, kommunale Finanzprobleme sowie Regulierungen und lange Verfahrensdauern entgegen. Die sprunghafte Erhöhung der Investitionsausgaben in künftigen Haushaltsplänen durch eine Änderung oder Umgehung der Schuldenbremse dürfte nicht zu entsprechend höheren realen Investitionen führen. Vielmehr ist davon auszugehen, dass wie in den vergangenen Jahren die Preise steigen und überschüssige Mittel von einem ins nächste Jahr verschoben werden. Die Schuldenbremse bietet derzeit genug Spielraum für eine schrittweise Steigerung der Investitionen, die angesichts der Hindernisse und Unsicherheiten angezeigt ist. Die Änderung oder Umgehung der Schuldenbremse ist in der Diskussion um öffentliche Investitionen derzeit fehlplatziert. Vielmehr besteht die Gefahr, die Glaubwürdigkeit der europäischen Fiskalregeln aufs Spiel zu setzen, die für das Funktionieren der Europäischen Währungsunion und für die unabhängige Geldpolitik notwendig sind.
Production of 67Cu by enriched 70Zn targets: first measurements of formation cross sections of 67Cu, 64Cu, 67Ga, 66Ga, 69mZn and 65Zn in interactions of 70Zn with protons above 45 MeV
Authors: Pupillo Gaia , Mou Liliana , Martini Petra , Pasquali Micòl , Boschi Alessandra , Cicoria Gianfranco , Duatti Adriano , Haddad Férid , Esposito Juan 
Published: February 2020

Abstract
Despite its insufficient availability, Copper-67 is currently attracting much attention for its enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately measure the unexplored cross section 70Zn(p,x)67Cu in the energy range 45–70 MeV and to evaluate its potential advantages in the case of high-intensity proton beams provided by compact cyclotrons. Thin target foils of enriched 70Zn were manufactured by lamination at the INFN-LNL and irradiated at the ARRONAX facility using the stacked-foils method. A radiochemical procedure for the separation of Cu, Ga and Zn contaminants and the isolation of 67Cu from the irradiated material was developed. The efficiency of the chemical processing was determined for each foil by monitoring the activity of selected tracer radionuclides (61Cu, 66Ga and 69mZn) through γ-spectrometry. Experimental data of the 70Zn(p,x)67Cu, 64Cu, 67Ga, 66Ga, 69mZn, 65Zn cross sections were measured for the first time in the energy range 45–70 MeV and compared with the theoretical results obtained by using the TALYS code. The 67Cu production yield by using enriched 70Zn thick targets was compared with the results obtained by using 68Zn targets in the same irradiation conditions.
Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review
Authors: Amoatey Patrick , Omidvarborna Hamid , Baawain Mahad Said , Al-Mamun Abdullah , Bari Aynul , Kindzierski Warren B. 
Published: February 2020

AbstractStudies on the assessment of indoor air pollutants in terms of concentration and characterization in the Gulf Cooperation Council (GCC) countries have been recently carried out. This review assesses the health effects associated with indoor air pollution exposures in GCC, including other air pollutants (siloxanes, flame retardants, synthetic phenolic antioxidants) which were not explored in a previous study. In addition, the influence of ventilation conditions due to different indoor environments was also investigated. It was revealed that there is a lack of human health assessment studies on most indoor air pollutants in almost all GCC countries, except the United Arab Emirates, Kingdom of Saudi Arabia and Kuwait, where few attempts were made for some specific pollutants. Commonly reported plausible health effects potentially associated with indoor air pollution were related to respiratory symptoms and sick building syndrome (SBS). Many of the current health assessment studies in GCC countries were based on predictions and/or estimates of exposures rather than clinically based observational studies. Measured ventilation levels and indoor air velocities in most buildings failed to meet the American Society of Heating, Refrigerating and Air-conditioning Engineers (ASHRAE) threshold limits of 8 L/s/p and 0.18–0.25 m/s, respectively. Additionally, limited studies have investigated respiratory symptoms and SBS potentially attributable to poor ventilation in the region. It is highly recommended that future indoor air quality (IAQ) studies in GCC should focus more on epidemiologic and intervention studies.
Investigation of MMP-9 rs3918242 and TIMP-2 rs8179090 polymorphisms in renal cell carcinoma tissues
Authors: Çaykara Burcu , Alsaadoni Hani , Pençe Sadrettin , Pençe Halime Hanım , Ötünçtemur Alper 
Published: February 2020

Abstract

Background
The proteolytic activities of matrix metalloproteinases (MMP), cell surface enzymes degrading extracellular matrix, is inhibited by matrix metalloproteinase tissue inhibitors (TIMP). We aim to detect the effects of MMP-9 rs3918242 and TIMP-2 rs8179090 gene variations in renal cell cancer transformation.

Methods
One hundred tumor and 100 adjacent healthy tissues were obtained from the patients with renal cell cancer. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was performed and the products carried out in agarose gel electrophoresis were visualized under UV light. Statistical analyses were performed using SPSS 22 and p-values of less than 0.05 were considered as statistically significant.

Results
MMP-9 rs3918242 T allele was higher in tumor tissues (36.5%) than adjacent tissues (17%) and odds ratio was found 2.8 in T allele (p<0.001). Odds ratio values were found 3.325 in the carriers of TT genotype and 3.5 in the carriers of CT genotype compared to the carriers of CC genotype (p<0.01). The polymorphism of TIMP-2 rs8179090 was not found statically significant in tumor and adjacent tissues (p>0.05).

Conclusion
MMP-9 rs3918242 T allele, TT and CT genotypes can be used as biomarkers in determining of renal cell carcinoma.
GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients
Authors: Chatterjee Sumana , Cottrell Emily , Rose Stephen J , Mushtaq Talat , Maharaj Avinaash V , Williams Jack , Savage Martin O , Metherell Louise A , Storr Helen L 
Published: February 2020

Objectives
The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity. We investigated whether transcript heterogeneity (6Ψ-GHR to WT-GHR transcript ratio) and/or concurrent defects in other short stature (SS) genes contribute to this.

Methods
6Ψ-GHR and WT-GHR mRNA transcripts of four 6Ψ patients (height SDS −4.2 to −3.1) and one control fibroblast were investigated by RT-PCR. Transcripts were quantified by qRT-PCR and delta delta CT analysis and compared using ANOVA with Bonferroni correction. In eleven 6Ψ patients, 40 genes known to cause GHI/SS were analysed by targeted next generation sequencing.

Results
RT-PCR confirmed 6Ψ-GHR transcript in the 6Ψ patients but not in the control. 6Ψ-GHR transcript levels were comparable in patients 1 and 3 but significantly different among all other patients. The mean 6Ψ:WT transcript ratios ranged from 29–71:1 for patients 1–4 and correlated negatively with height SDS (R = −0.85; P < 0.001). Eight deleterious variants in six genes were detected, but the number of gene hits did not correlate with the degree of SS in individual 6Ψ patients.

Conclusion
Variable amounts of 6Ψ- and WT-GHR transcripts were identified in 6Ψ patients but no 6Ψ transcript was present in the control. Higher 6Ψ:WT-GHR transcript ratio correlated with SS severity and may explain the phenotypic variability. Analysis of known SS genes suggested that phenotypic variation is independent of the genetic background. This is the first report of transcript heterogeneity producing a spectrum of clinical phenotypes in different individuals harbouring an identical homozygous genetic mutation.
Decoupling of Apoptosis from Activation of the ER Stress Response by theDrosophilaMetallopeptidasesuperdeath
Authors: Palu Rebecca A S , Dalton Hans M , Chow Clement Y 
Published: February 2020

AbstractGenetic diseases display a great deal of variability in patient outcomes, much of which is caused by differences in genetic background. The endoplasmic reticulum (ER) stress response commonly modifies degenerative disease...Endoplasmic reticulum (ER) stress-induced apoptosis is a primary cause and modifier of degeneration in a number of genetic disorders. Understanding how genetic variation influences the ER stress response and subsequent activation of apoptosis could improve individualized therapies and predictions of outcomes for patients. In this study, we find that the uncharacterized, membrane-bound metallopeptidase CG14516 in Drosophila melanogaster, which we rename as SUPpressor of ER stress-induced DEATH (superdeath), plays a role in modifying ER stress-induced apoptosis. We demonstrate that loss of superdeath reduces apoptosis and degeneration in the Rh1G69D model of ER stress through the JNK signaling cascade. This effect on apoptosis occurs without altering the activation of the unfolded protein response (IRE1 and PERK), suggesting that the beneficial prosurvival effects of this response are intact. Furthermore, we show that superdeath functions epistatically upstream of CDK5—a known JNK-activated proapoptotic factor in this model of ER stress. We demonstrate that superdeath is not only a modifier of this particular model, but affects the general tolerance to ER stress, including ER stress-induced apoptosis. Finally, we present evidence of Superdeath localization to the ER membrane. While similar in sequence to a number of human metallopeptidases found in the plasma membrane and ER membrane, its localization suggests that superdeath is orthologous to ERAP1/2 in humans. Together, this study provides evidence that superdeath is a link between stress in the ER and activation of cytosolic apoptotic pathways.
Філософський аналіз еволюції штучного інтелекту
Authors: Добровольська О. В. , В. І. Штанько 
Published: February 2020

Здійснено аналіз сучасного стану розвитку напряму штучного інтелекту з філософської точки зору. Ґрунтуючись на порівняльно-історичному аналізі, з’ясовано, що спричинило кризи в межах цієї сфери, визначено основні обмеження філософського характеру, які не дозволяють створити «сильну» форму штучного інтелекту: його нездатність до саморефлексії, відчуттів, творчості та гнучкої поведінки; обмеження обчислювального підходу; неможливість повної формалізації знання.
Проаналізовано, чим обумовлені успіхи в межах галузі в останнє десятиліття, і чи були подолані раніше виявлені обмеження. З’ясовано, що еволюція напряму ґрунтується на технічних досягненнях останніх років, що допомогло реалізації алгоритмів, які раніше вимагали багатогодинних обчислень. Визначено, що господарювання прагматичного підходу в галузі призвело до роздрібнення досліджень, фрагментації і спрощення уявлення про світ задля вирішення конкретних задач. З’ясовано, що успішне програмне імітування людської діяльності в різних сферах і неможливість вирішення філософських проблем призвели до розвитку тільки «слабкої» форми штучного інтелекту.
Проведене дослідження показало, що через “однобічний” технічний розвиток і відкритість філософських проблем не можна говорити про еволюцію напряму в цілому.
Modality and folk psychology
Authors: Petik Ja. O. 
Published: February 2020

The connection of the modern psychology and formal systems remains an important direction of research. This paper is centered on philosophical problems surrounding relations between mental and logic. Main attention is given to philosophy of logic but certain ideas are introduced that can be incorporated into the practical philosophical logic.
The definition and properties of basic modal logic and descending ones which are used in study of mental activity are in view. The defining role of philosophical interpretation of modality for the particular formal system used for research in the field of psychological states of agents is postulated. Different semantics of modal logic are studied. The hypothesis about the connection of research in cognitive psychology (semantics of brain activity) and formal systems connected to research of psychological states is stated.
Вклад ученых и конструкторов ГП «КБ «Южное» им. М. К. Янгеля» в изучение механических колебаний в ракетной технике К 65-летию ГП «КБ «Южное»»
Authors: Е. В. Никифорова  , Г. И. Сокол  , А. С. Лучко  
Published: February 2020

В работе обобщены результаты и проведен анализ работ ученых и конструкторов ГП «КБ «Южное» им. М. К. Янгеля» по изучению колебаний и волн в ракетно-космической технике (РКТ). Рассмотрены монографии, диссертации, статьи, в которых исследованы процессы динамики ракетоносителей и космических аппаратов. Достижения коллектива включают в себя важные научно- исследовательские работы из области механических колебаний и волн. Ключевым направлением в развитии РКТ стало не только их изучение, но рождение многих изобретений, которые легли в основу методов гашения вибраций и явлений неустойчивости в работе двигателей. В большинстве своем научно- конструкторские разработки имели грифы «секретно» и «совершенно секретно». Работы ученых, работавших в этих учреждениях, длительное время не были достоянием научной общественности.
В работе представлена история рождения фундаментальных идей применительно к динамике ракетных конструкций. Представлен исторический вклад в развитие идей механических колебаний и волн отдельных ученых – личностей и их научных школ.
The Political and Economic Dimensions of China’s Relations with Latin America ( الابعاد السياسية والاقتصادية لعلاقات الصين مع امريكا اللاتينية )
Authors: Dheyaa Shkara Prof. Nadia 
Published: February 2020

This research uses scientific analysis to look at China's relations with Latin American countries, especially its investment in those countries.
There are two objectives behind Chinese investments in South America.
The first is to solidify its position as the second largest economic power in the world after the United States of America. China's position is further ensured by its huge store of raw materials and energy sources that support its accelerating economic needs of energy to keep pace with the steady growth of its economy.
The second objective is to prevent and deter the United States of America from harming the growing Chinese interests in the world by restricting the effects of the American Containment and Pivot strategies, which revealed the determination of the American administration to besiege China, and its growing influence, economically & politically by alliances & treaties, and to besiege China militarily by American bases Japan, South Korea, the Philippines and others of China's neighbors.
Thus, China considered it only fair to retaliate by strengthening its relations with U.S.A. neighbors, especially the Latin American countries who are U.S.A.'s backyard and strategic backers, and who can restrict the American ability to harm China's vital interests.