bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subaru Hyper Suprime-Cam view of quasar host galaxies at z &lt; 1
Authors: Ishino Toru , Matsuoka Yoshiki , Koyama Shuhei , Saeda Yuya , Strauss Michael A , Goulding Andy D , Imanishi Masatoshi , Kawaguchi Toshihiro , Minezaki Takeo , Nagao Tohru , Noboriguchi Akatoki , Schramm Malte , Silverman John D , Taniguchi Yoshiaki , Toba Yoshiki 
Published: July 2020

Abstract
Active galactic nuclei (AGNs) are key in understanding the coevolution of galaxies and supermassive black holes (SMBHs). AGN activity is thought to affect the properties of their host galaxies via a process called “AGN feedback,” which drives the coevolution. From a parent sample of 1151 z &lt; 1 type-1 quasars from the Sloan Digital Sky Survey quasar catalog, we detected the host galaxies of 862 of them in the high-quality grizy images of the Subaru Hyper Suprime-Cam survey. The unprecedented combination of the survey area and depth allowed us to perform a statistical analysis of the quasar host galaxies, with small sample variance. We fitted the radial image profile of each quasar as a linear combination of the point spread function and the Sérsic function, decomposing the images into the quasar nucleus and the host galaxy components. We found that the host galaxies are massive, with stellar mass Mstar ≳ 1010 $M_\odot$, and are mainly located on the green valley. This trend is consistent with a scenario in which star formation in the host galaxies is suppressed by AGN feedback, that is, AGN activity may be responsible for the transition of these galaxies from the blue cloud to the red sequence. We also investigated the SMBH mass to stellar mass relation of the z &lt; 1 quasars, and found a consistent slope with the local relation, while the SMBHs may be slightly undermassive. However, the above results are subject to our sample selection, which biases against host galaxies with low masses and/or large quasar-to-host flux ratios.
Application of High-Intensity Functional Resistance Training in a Skilled Nursing Facility: An Implementation Study
Authors: Gustavson Allison M , Malone Daniel J , Boxer Rebecca S , Forster Jeri E , Stevens-Lapsley Jennifer E 
Published: July 2020

Abstract

Objective
Rehabilitation in skilled nursing facilities (SNFs) is under scrutiny to deliver high-quality care and superior outcomes in less time. High-intensity resistance training demonstrates functional improvements in community-dwelling and long-term care populations but has not been generalized to the SNF population. The purpose of this study was to evaluate implementation issues including safety and feasibility and to provide preliminary information on effectiveness of rehabilitation focused on high-intensity functional resistance training in an SNF.

Methods
The implementation study design consisted of 2 nonrandomized independent groups (usual care and high intensity) that were staged within a single SNF. The i-STRONGER program (IntenSive Therapeutic Rehabilitation for Older Skilled NursinG HomE Residents) integrates principles of physiologic tissue overload into rehabilitation. Physical therapists administered the Short Physical Performance Battery and gait speed at evaluation and discharge. Reach, Effectiveness, Adoption, Implementation, and Maintenance was used to evaluate the implementation process. An observational checklist and documentation audits were used to assess treatment fidelity. Regression analyses evaluated the response of functional change by group.

Results
No treatment-specific adverse events were reported. Treatment fidelity was high at &gt;99%, whereas documentation varied from 21% to 50%. Patient satisfaction was greater in i-STRONGER, and patient refusals to participate in therapy sessions trended downward in i-STRONGER. Patients in i-STRONGER exhibited a 0.13 m/s greater change in gait speed than in the usual care group. Although not significant, i-STRONGER resulted in a 0.64-point greater change in the Short Physical Performance Battery than usual care, and average SNF length of stay was 3.5 days shorter for i-STRONGER patients.

Conclusion
The findings from this study indicate that implementation of a high-intensity resistance training framework in SNFs is safe and feasible. Furthermore, results support a signal effectiveness of improving function and satisfaction, although the heterogeneity of the population necessitates a larger implementation study to confirm.

Impact Statement
This pragmatic study demonstrates that high-intensity resistance training in medically complex older adults is safe and favorable in SNFs. This work supports the need to fundamentally change the intensity of rehabilitation provided to this population to promote greater value within post-acute care. Furthermore, this study supports the application of implementation science to rehabilitation for rapid and effective translation of evidence into practice.
Site Index Curves for Direct-Seeded Loblolly and Longleaf Pines in Louisiana
Authors: Cao Quang V. , Baldwin V. Clark , Lohrey Richard E. 
Published: July 2020

Abstract
Site index equations were developed for direct-seeded loblolly pine (Pinus taeda L.) and longleaf pine (Pinus palustris Mill.) based on data from 148 and 75 permanent plots, respectively. These plots varied from 0.053 to 0.119 ac in size, and were established in broadcast, row, and spot seeded stands throughout Louisiana. The Bailey and Clutter (1974) model was selected for stand height prediction. Site index curves are presented for both species based on these equations. These site index models should provide satisfactory short-term height projection for direct-seeded loblolly and longleaf pine stands in Louisiana. South. J. Appl. For. 21(3):134-138.
Contextualizing Educational Disparities and the Evaluation of Teacher Quality
Authors: Shifrer Dara 
Published: July 2020

Abstract
Value added scores, statistical estimates of teacher quality, are representative of neoliberal logic. The higher average scores of teachers of socially advantaged students raise concerns that scores are inaccurate and unfair, and propagate decontextualized neoliberal understandings of the nature of learning and teachers’ work. This study uses longitudinal data from roughly 4,500 teachers in a large urban district between 2007–08 through 2012–13 to follow individual teachers as they switch into schools of different “performance levels” over time. Fixed-intercept models tracking individual teachers between 2007–08 and 2012–13 showed scores increased for teachers who switched into high-performing schools and decreased for teachers who switched into low-performing schools. Particularly indicative of scores biased by contextual factors outside teachers’ control, score changes for mobile teachers are partially attributable to shifts in the economic status and race of students in teachers’ classrooms and schools. Understanding how neoliberalism operates within education provides sociological insight into how neoliberalism is legitimated and perpetuated in other central social institutions, such as the criminal justice system, the environment, gender, sexuality, and health.
Effect of rumen-protected lysine on growth performance, carcass characteristics, and plasma amino acid profile in feedlot steers
Authors: Heiderscheit Katie J , Hansen Stephanie L 
Published: July 2020

Abstract
The objective of this study was to evaluate growth performance, carcass characteristics, and plasma amino acid profiles of feedlot steers fed rumen-protected Lys. Forty-two Angus-cross steers (304 ± 25 kg) were blocked by weight and fed treatment diets for 180 d (growing days 0 to 55; finishing days 56 to 180): 1) Lys-deficient diet (CON; n = 12 steers), 2) Lys-adequate diet containing soybean meal (POS; n = 12 steers), or 3) Lys-deficient diet plus supplemental rumen-protected Lys (RPL; AjiPro-L; Ajinomoto Animal Nutrition North America, Eddyville, IA; n = 18 steers). Consecutive day bodyweights (BWs) were recorded to begin and end growing and finishing. Individual steer dry matter intake (DMI) was recorded. Blood was collected on days 0, 56, and 179 for analysis of physiological free amino acids. Steers were harvested on day 180 and carcass characteristics were recorded. Data were analyzed using Proc Mixed of SAS 9.4. Steer was the experimental unit and treatment was the fixed effect for all parameters. Block was a fixed effect for growth performance, feed intake, and carcass data. The day 0 value for each parameter of physiological free amino acids was used as a covariate during analysis. The CON steers had greater BW, average daily gain (ADG), and gain to feed (G:F) at the end of growing (day 56; P ≤ 0.05) vs. POS and RPL. The CON steers also had greater final BW (P = 0.04) and overall ADG (P = 0.04) than RPL, while POS was intermediate. Carcass characteristics were not different across treatments [hot carcass weight, dressing percent, ribeye area, back fat, kidney/pelvic/heart (KPH) percent, marbling, or calculated yield grade; P ≥ 0.13]. Plasma urea N was greater in POS steers on days 56 and 179 (P ≤ 0.04). Plasma Lys and Arg concentrations were greater in POS at day 56 (P ≤ 0.02); however, there was no difference among treatments for these two variables at day 179 (P ≥ 0.44). Steers in all treatments had greater DMI than predicted, causing a negative metabolizable Lys balance for all treatments during growing. Though the metabolizable Lys balance was positive for POS and RPL-fed steers during finishing, the increased metabolizable Lys in these treatments may have decreased performance if other amino acids were imbalanced due to increased intakes.
Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway
Authors: Salama Rania M , Mohamed Abdelkader M , Hamed Nada S , Ata Raneem M , NourelDeen Amira S , Hassan Mohamed A 
Published: July 2020

AbstractCyclophosphamide (CP) is one of the most potent alkylating agents and is widely used in the treatment of numerous neoplastic conditions, autoimmune diseases and following organ transplantation. Due to its ability to induce oxidative stress and subsequent apoptosis, CP is affiliated with many adverse effects with special emphasis on the highly prevalent hepatotoxicity. Dipeptidyl peptidase 4 (DDP-IV) inhibitors are being rediscovered for new biological effects due to their ability to target multiple pathways, among which is the phosphoinositide 3–kinase (PI3K) and protein kinase B (Akt) axis. This could offer protection to multiple organs against reactive oxygen species (ROS) through modulating sirtuin 1 (SIRT1) expression and, in turn, inactivation of forkhead box transcription factor of the O class 1 (FoxO1), thus inhibiting apoptosis. Accordingly, the current study aimed to investigate the potential therapeutic benefit of alogliptin (Alo), a DPP-IV inhibitor, against CP-induced hepatotoxicity through enhancing PI3K/Akt/SIRT1 pathway. Forty male Wistar rats were randomly divided into four groups. The CP-treated group received a single dose of CP (200 mg/kg; i.p.). The Alo-treated group received Alo (20 mg/kg; p.o.) for 7 days with single CP injection on Day 2. Alo successfully reduced hepatic injury as witnessed through decreased liver function enzymes, increased phospho (p)-PI3K, p-Akt, superoxide dismutase (SOD) levels, SIRT1 expression, p-FoxO1 and anti-apoptotic B-cell lymphoma 2 (Bcl-2). This resulted in decreased apoptosis, as witnessed through decreased caspase-3 levels and improved histopathological picture. In conclusion, the current study succeeded to elaborate, for the first time, the promising impact of Alo in ameliorating chemotherapy-induced liver injury.
Microscopic and biochemical changes on liver and kidney of Wistar rats on combination antiretroviral therapy: the impact of naringenin and quercetin
Authors: Akang Edidiong Nnamso , Dosumu Olufunke O , Okoko Ini-ibehe Essien , Faniyan Oluwatomisin , Oremosu Ademola A , Akanmu Alani Sulaimon 
Published: July 2020

AbstractCombination antiretroviral therapy (cART), which is a lifelong therapy for people living with human immunodeficiency virus, has been associated with nephrotoxicity and hepatotoxicity leading to its discontinuation. This study aimed at investigating the ameliorative potential of naringenin and quercetin on cART-induced hepatotoxicity and nephrotoxicity. Seventy male Wistar rats (225–260 g) were divided into seven groups as control, cART, naringenin, quercetin, dimethyl sulfoxide (DMSO), naringenin/cART (CN) and quercetin/cART (CQ). cART (24 mg/kg), naringenin (50 mg/kg) and quercetin (50 mg/kg) were dissolved in 1% v/v DMSO and administered orally for 56 days. Combination of cART and bioflavonoids had significant increase in superoxide dismutase (P &lt; 0.05), catalase (P &lt; 0.01), reduced glutathione (P &lt; 0.001) and decreased malondialdehyde (P &lt; 0.001) compared to cART only. Tumor necrosis factor Alpha (TNFα) level increased significantly in cART and CQ (P &lt; 0.01) groups, while others showed no significant changes compared to control. TNFα also significantly decreased in CQ level compared to cART (P &lt; 0.001). In addition, significant increase in creatinine level in cART only indicated progressive renal toxicity. Also, progressive pathological changes including congested blood vessels and hepatocellular necrosis were found in the liver, while the kidney had glomerular atrophy, and tubular distortion in cART-only group. Control, naringenin- and quercetin-treated groups showed normal renal and hepatic cytoarchitecture. These findings elucidate that progressive renal and hepatic toxicity is associated with the continuous use of cART; however, a combination of quercetin and naringenin with cART showed possible potential of ameliorating the damages posed by cART.
PtKTI12genes influence wobble uridine modifications and drought stress tolerance in hybrid poplar
Authors: Wang Hailang , Xu Chao , Zhang Youbing , Yan Xu , Jin Xiaohuan , Yao Xiaoqing , Chen Peng , Zheng Bo 
Published: July 2020

ABSTRACTThe multisubunit Elongator complex plays key roles in transcription by interacting with RNA polymerase II and chromatin modeling. Kti proteins have been identified as the auxiliary protein for the Elongator complex. However, our knowledge of Kti proteins in woody plants remains limited. In this study, in total 16 KTI gene homologs were identified in Populus trichocarpa. Among them, the two KTI12 candidates were named PtKTI12A and PtKTI12B. Although PtKTI12A and PtKTI12B were largely different in gene expression level and tissue specificity, both genes were induced by heat and drought stresses. PtKTI12A and PtKTI12B RNAi transgenic poplar plants showed reduced levels of modified nucleosides, in particular 5-carbamoylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine. Meanwhile, their tolerance to drought was improved when subjected to withdrawal of watering. Also, the protein products of PtKTI12A and PtKTI12B had similar subcellular localization and predicted tertiary structure. The results suggest that Kti12 proteins are involved in tRNA wobble uridine modification, stress response and drought stress tolerance in hybrid poplar.
Developing consensus of evidence to target case finding surveys for podoconiosis: a potentially forgotten disease in India
Authors: Simpson Hope , Panicker K N , George Leyanna Susan , Cano Jorge , Newport Melanie J , Davey Gail , Deribe Kebede 
Published: July 2020

Abstract

Background
Podoconiosis is a non-infectious geochemical lymphoedema of the lower legs associated with a significant burden of morbidity. There are historical reports of podoconiosis in India, but its current endemicity status is uncertain. In this investigation we aimed to prioritise the selection of districts for pilot mapping of podoconiosis in India.

Methods
Through a consultative workshop bringing together expert opinion on podoconiosis with public health and NTDs in India, we developed a framework for the prioritisation of pilot areas. The four criteria for prioritisation were predicted environmental suitability for podoconiosis, higher relative poverty, occurrence of lymphoedema cases detected by the state health authorities and absence of morbidity management and disability prevention (MMDP) services provided by the National Programme for Elimination of Lymphatic Filariasis.

Results
Environmental suitability for podoconiosis in India was predicted to be widespread, particularly in the mountainous east and hilly southwest of the country. Most of the districts with higher levels of poverty were in the central east and central west. Of 286 districts delineated by state representatives, lymphoedema was known to the health system in 189 districts and not recorded in 80. Information on MMDP services was unavailable for many districts, but 169 were known not to provide such services. We identified 35 districts across the country as high priority for mapping based on these criteria.

Conclusions
Our results indicate widespread presence of conditions associated with podoconiosis in India, including areas with known lymphoedema cases and without MMDP services. This work is intended to support a rational approach to surveying for an unrecognised, geographically focal, chronic disease in India, with a view to scaling up to inform a national strategy if required.
Pattern of Deterioration and Recovery of Wood from Dead Yellow-Cedar in Southeast Alaska
Authors: Hennon Paul E. , Wittwer Dustin T. , Stevens John , Kilborn Ken 
Published: July 2020

Abstract
Live yellow-cedar (Chamaecyparis nootkatensis) trees and five classes of snags dead up to 81 yr were contrasted based on the following: the retention of bark and sapwood; the penetration of stain, decay, and weather checks; and the volume and grade of lumber recovered. Of 138 sample trees, most bark was retained on the boles of trees dead &lt;14 yr but thereafter sloughed away and was generally missing by 51 yr after death. Stain, decay, and weather checks were limited to the narrow sapwood on snags 26 yr after tree death (n = 280 log end surfaces). Weather checking, the most serious deterioration defect in snags, did not encroach on heartwood until the sapwood was missing some 51 yr after death. Checking penetration averaged 1.3 in. for the last two snag classes. Cubic volume recovery from 305 mill-length logs did not differ significantly by classes of live trees or snags dead up to 26 yr, and the significant reduction in recovery from snags dead 51 and 81 yr was less than 15%. Grades of lumber were generally similar among the classes of trees, but no clear lumber was recovered from the oldest snag class. These results indicate little to no measurable difference of recovered wood from live trees and the first three snag classes, dead up to 26 yr, and a modest reduction in volume and grade in snags dead up to 81 yr. West. J. Appl. For. 15(2):49-58.
Evaluation of mental health stigma on medical education: an observational study with Portuguese medical students
Authors: Pinto Inês C. , Bernardo Margarida , Sousa Sara , Curral Rosário 
Published: July 2020

Abstract

Background:
The Portuguese mental health care plan emphasizes that health care professionals can be a source of stigma against people with mental illness enhancing self-stigma and leading to a decrease in the search for help and adherence to treatment.

Methods:
In this exploratory study, we surveyed 111 first and last year students from the Faculty of Medicine of the University of Porto, Portugal, using the Portuguese version of the Attribution Questionnaire AQ-27 to assess the attitudes toward mental illness.

Results:
The students showed a significant difference in the segregation dimension, and in some items related with pity and coercion in the end of the course. These results express a positive will to integrate people with mental illness in community, a decrease of pity and a valorization of the pharmacological treatment in this kind of disease. The previous personal experience of psychiatric problems decreases the level of segregation and psychological problems increase the motivation to help.

Conclusion:
Final-year students express more positive and less discriminatory attitudes toward people with severe mental illness than first-year students. This is likely due to education and contact opportunities promoted throughout the medical school, as well as due to the experience of having gone to a psychology or psychiatric consultation. Knowledge of stigma levels of future medical doctors is therefore crucial for the prevention of attitudes that could condition the provision of medical care.
Comparison of the efficacy between concurrent chemoradiotherapy with or without adjuvant chemotherapy for stage II nasopharyngeal carcinoma
Authors: Chen Jing , Liu Tongxin , Sun Quanquan , Jin Ting 
Published: July 2020

Abstract

Background:
Although common, the use of concurrent chemoradiotherapy with adjuvant chemotherapy for stage II nasopharyngeal carcinoma (NPC) is controversial due to its undefined clinical benefits. We, therefore, conducted a retrospective cohort study to investigate whether adjuvant chemotherapy confers survival gains to stage II NPC patients.

Methods:
In this study, we examined whether combining adjuvant chemotherapy (AC) and/or concurrent chemotherapy with radiotherapy (CCRT) improved survival in patients with stage II NPC. Three hundred thirty-five stage II NPC patients were retrospectively analyzed between June 2003 and June 2016 and received CCRT; some patient groups also received AC every 3 weeks for 2 to 3 cycles.

Results:
The median follow-up duration was 72 months for all patients (range, 26–151 months) and the estimated 5-year locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) rates were 95.1%, 97.8%, 93.5%, and 94.3%. At the last follow-up, there were no statistically significant differences among the CCRT and CCRT+AC groups in 5-year LRRFS (95.2% vs 94.9%, P = .599), DMFS (98.5% vs 92.4%, P = .152), PFS (93.8% vs 90.2%, P = .599), or OS (95.5% vs 93.9%, P = .682) rates.

Conclusion:
The analyses revealed that a combined regimen was not an independent prognostic factor for any survival outcome. However, patients who received CCRT plus AC experienced more acute adverse events than those who received CCRT alone. Thus, the addition of AC to CCRT did not improve survival outcomes, but was associated with higher incidences of acute treatment-associated toxicities than CCRT alone in patients with stage II NPC.
Phenotypic spectrum and genetic analysis in the fatal cases of Schaaf-Yang syndrome
Authors: Chen Xuefei , Ma Xiaolu , Zou Chaochun 
Published: July 2020

Abstract

Rationale:
Schaaf-Yang syndrome, a rare imprinted hereditary disease caused by MAGEL2 variants, manifests as developmental delay/intellectual disability, neonatal hypotonia, feeding difficulties, contractures, and autism spectrum disorder.

Patient concerns:
Patient 1 and 2 were infant girls presenting facial dysmorphisms, contractures of interphalangeal joints, neonatal hypotonia, feeding difficulties, congenital heart diseases, and respiratory complications. Besides, Patient 2 presented with delayed psychomotor development.

Diagnosis:
Whole-exome sequencing was performed and heterozygous mutations of the MAGEL2 gene were detected in the patients. They were diagnosed as Schaaf-Yang syndrome.

Interventions:
The patients received supportive treatment including mechanical ventilation, parenteral nutrition and gastric tube feeding.

Outcomes:
Whole-exome sequencing revealed de novo heterozygous c.1996dupC pathogenic mutations in the MAGEL2 gene in the 2 patients. They died due to respiratory failure at the age of 20 days and 98 days, respectively.

Lessons:
Our results indicate that MAGEL2 variants can cause congenital heart disease and fatal respiratory complications, broadening the phenotypic spectrum and adding to the fatal cases of Schaaf-Yang syndrome. We highly suggest that the MAGEL2 gene should be added to gene-panels or gene-filters in next-generation sequencing-based diagnostics, which is of great significance for early diagnosis and early intervention of Schaaf-Yang syndrome patients.