bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitric oxide coordinates histone acetylation and expression of genes involved in growth/development and stress response
Authors: Ageeva-Kieferle Alexandra , Georgii Elisabeth , Winkler Barbro , Ghirardo Andrea , Albert Andreas , Hüther Patrick , Mengel Alexander , Becker Claude , Schnitzler Jörg-Peter , Durner Jörg , Lindermayr Christian 
Published: June 2020

AbstractNitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. Besides direct effects on the transcriptional machinery, NO can fulfill its signaling function via epigenetic mechanisms.We report that light intensity-dependent changes in NO correlate with changes in global histone acetylation (H3, H3K9 and H3K9/K14) inArabidopsis thalianawild-type leaves and that this correlation depends on S-nitrosoglutathione reductase and histone deacetylase 6. The activity of histone deacetylase 6 was sensitive to NO, which demonstrates that NO participates in regulation of histone acetylation. ChIP-seq and RNA-seq analyses revealed that NO is involved in the metabolic switch from growth and development to stress response. This coordinating function of NO might be of special importance in adaptation to a changing environment and could therefore be a promising starting point to mitigating the negative effects of climate change on plant productivity.
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins
Authors: Steblyanko Yulia , Rajendraprasad Girish , Osswald Mariana , Eibes Susana , Geley Stephan , Pereira António J. , Maiato Helder , Barisic Marin 
Published: June 2020

AbstractMitotic spindle microtubules (MTs) undergo continuous poleward flux, whose driving force and function in humans remain unclear. Here, we combined loss-of-function screenings with analysis of MT dynamics in human cells to investigate the molecular mechanisms underlying MT-flux. We report that kinesin-7/CENP-E at kinetochores (KTs) is the predominant driver of MT-flux in early prometaphase, while kinesin-4/KIF4A on chromosome arms facilitates MT-flux during late prometaphase and metaphase. We show that both of these activities work in coordination with MT-crosslinking motors kinesin-5/EG5 and kinesin-12/KIF15. Our data further indicate that MT-flux driving force is transmitted from non-KT MTs to KT-MTs via MT-coupling by HSET and NuMA. Moreover, we found that MT-flux rate correlates with spindle size and this correlation depends on the establishment of stable end-on KT-MT attachments. Strikingly, we revealed that flux is required to counteract the kinesin 13/MCAK-dependent MT-depolymerization to regulate spindle length. Thus, our study demonstrates that MT-flux in human cells is driven by the coordinated action of four kinesins, and is required to regulate mitotic spindle size in response to MCAK-mediated MT-depolymerizing activity at KTs.
Language impairment with a partial duplication of DOCK8
Authors: Benítez-Burraco Antonio , Fernández-Urquiza Maite , Jiménez-Romero Mª Salud 
Published: June 2020

ABSTRACTCopy-number variations of the distal region of the short arm of chromosome 9 are associated with learning disabilities and behavioral disturbances. Deletions of the 9p are more frequent than duplications. We report in detail on the cognitive and language features of a child with a duplication in the 9p24.3 region (arr[hg19] 9p24.3(266,045-459,076)x3). He exhibits marked expressive and receptive problems, which affect to both structural aspects of language (notably, inflectional morphology, complex syntax, and sentence semantics), and to functional aspects (pragmatics). These problems might result from a severe underlying deficit in working memory. Regarding the molecular causes of the observed symptoms, they might result from the altered expression of selected genes involved in procedural learning, particularly, some of components of the SLIT/ROBO/FOXP2 network, strongly related to the development and evolution of language. Dysregulation of specific components of this network can result in turn from an altered interaction between DOCK8, affected by the microduplication in 9p24.3 borne by our proband, and CDC42, acting as the hub component of the network encompassing language-related genes. Still, some genes found strongly upregulated in the subject and not related to these genes, particularly NRCAM, can contribute to the observed problems in the language domain, as well as to specific features of the proband, particularly, his impulsivity.
Personalized vagino-cervical microbiome dynamics after oral probiotics
Authors: Chen Chen , Hao Lilan , Tian Liu , Song Liju , Zhang Xiaowei , Jie Zhuye , Tong Xin , Xiao Liang , Zhang Tao , Jin Xin , Xu Xun , Yang Huanming , Wang Jian , Kristiansen Karsten , Jia Huijue 
Published: June 2020

AbstractThe vaginal microbiota is presumably much simpler than the gut microbiome, and oral probiotics appear as a promising means to modulate its homeostasis in the general population. Here, 60 women were followed for over a year before, during and after a probiotic containingLactobacillus rhamnosusGR-1 andL. reuteriRC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support colonization of the probiotics to the vagino-cervical microbiome, yet the microbiome was stable in those dominated by Lactobacilli and some individuals have likely benefited from this medication-free intervention.
Symmetry and Painlevé analysis for the extended Sakovich equation
Authors: Wang Gangwei , Wazwaz Abdul-Majid 
Published: June 2020

Purpose
The purpose of this paper is to concern with introducing symmetry analysis to the extended Sakovich equation.

Design/methodology/approach
The newly developed Sakovich equation has been handled by using the Lie symmetries via using the Lie group method.

Findings
The developed extended Sakovich model exhibit symmetries and invariant solutions.

Research limitations/implications
The present study is to address the two main motivations: the study of symmetry analysis and the study of soliton solutions of the extended Sakovich equation.

Practical implications
The work introduces symmetry analysis to the Painlevé-integrable extended Sakovich equation.

Social implications
The work presents useful symmetry algorithms for handling new integrable equations.

Originality/value
The paper presents an original work with symmetry analysis and shows useful findings.
Thermal effect on stability and minimum oil film thickness of a deep/shallow pockets conical bearing
Authors: Wu Ningning , Guo Hong , Yang Shuai , Zhang Shaolin 
Published: June 2020

PurposeThis paper aims to study the influence of thermal effect on the performance for a high-speed conical hybrid bearing including stability and minimum oil film thickness.Design/methodology/approachA thermal hydrodynamic (THD) model and dynamic model of single mass rigid rotor system were established by taking conical hybrid bearing with shallow and deep pockets as the research object, dynamic coefficient and stability parameters of bearing-rotor system were obtained by using finite element method (FEM) and finite difference method (FDM) to solve computational models of Reynolds equation, energy equation and viscosity-temperature equation. Minimum oil film thickness was obtained based on bearing force balance. Dynamic coefficient was compared with previous findings.FindingsAfter considering thermal effect, the dimensionless critical mass decreases, a significant decrease in the instability speed, and the stability of the system decreases greatly; the minimum oil film thickness decreases because of thermal effect.Originality/valueThe thermal effect is combined with dynamic characteristics to analyze stability of the rotor system for a conical hybrid bearing. Influence of thermal effect on minimum oil film thickness is studied.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/ILT-12-2019-0542/
How does mobile social media affect knowledge sharing under the “Guanxi” system?
Authors: Zhang Xi , Tang Jiaxin , Wei Xin , Yi Minghui , Ordóñez de Pablos Patricia 
Published: June 2020

Purpose
The purpose of this paper is to explore the impact of mobile social media functions on explicit and implicit knowledge sharing under the “Guanxi” system based on the framework of stimulus–organism–response (SOR).

Design/methodology/approach
Combined with Guanxi theory, this paper designs an experiment to collect data from the new product development (NPD) teams.

Findings
Interestingly, the results show that the effect of social media communication function on employees is greater than the impact of collaboration on employees. Specifically, on the one hand, the more employees communicate in social media, the better their feelings will be, the less they will share knowledge. On the other hand, the collaboration function has a significantly negative impact on the psychological factors of employees. Excessively close cooperation and contact may instead create a contradiction between the employees, which is not conducive to the occurrence of knowledge sharing.

Originality/value
This paper extends SOR framework by combining Guanxi theory to examine the relationship between social media functions and knowledge sharing behavior (KSB). In practical, companies should pay attention to the frequency of employee using social media when it is introduced for NPD teams to control the negative influence of social media functions on employee KSB.
Correlation of anthropometric indices with lipid profile indices among Malay obese and non-obese subjects in Malaysia
Authors: Nadeem Muhammad Ilyas , Abu Bakar Yasrul Izad , Akram Sana , Baig Atif Amin 
Published: June 2020

PurposeThis study aims to determine the correlation of anthropometric measurements with serum lipid profile among Malay subjects in Kuala Terengganu, Malaysia.Design/methodology/approachThis cross-sectional study was conducted in Kuala Terengganu on a total of 193 individuals aged 18-60 years. Subjects were recruited via direct interview as per inclusion criteria and anthropometric measurements, i.e. body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio, abdominal volume index and conicity index, were taken using International Standards for Anthropometric Assessment Guidelines. Fasting blood samples were collected for serum lipid profile analysis that measures triglyceride (TG), total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL), TG/HDL, TC/HDL and LDL/HDL. Besides socio-demographic characteristics, means and association of anthropometric parameters with lipid profiles were performed using simple linear regression and multivariate-adjusted regression analysis.FindingsThe mean age of obese (male [39.2 ± 8.7] and female [41.1 ± 1.0]) and non-obese (male [29.8 ± 1.3] and female [33.3 ± 1.3]) respondents was compared. Means of anthropometric indices and lipid profile were significantly (p< 0.001) higher in obese than in non-obese group. Multivariate-adjusted regression showed that weight and BMI increased risks for prevalent high TC, TG, LDL, TC/HDL, TG/HDL, LDL/HDL, hypercholesterolemia, hypertriglyceridemia and dyslipidemia. Regardless of sex, age and prevalent obese status, WHR increased risks for high prevalence of TC, TG, LDL, TC/HDL and LDL/HDL, and presents an independent risk factor for hypercholesterolemia and dyslipidemia. WC was highly associated with TG, while HC was associated with atherogenic lipid profile ratios: TC/HDL, TG/HDL and LDL/HDL.Originality/valueIn conclusion, the lipid profile (TC, TG and TG/HDL) of triglyceridemia and hypercholesteremia is highly correlated with anthropometric measurements (BMI, WC and WHR) of central obesity that predict obesity-associated cardiac risks.
Unpacking ‘patient‐centredness’: how knowledge is negotiated dialogically in the interweaving of genres and voices in counselling conversations
Authors: Phillips Louise , Scheffmann‐Petersen Michael 
Published: June 2020

AbstractIn the literature, difficulties in implementing policy principles of patient‐centredness are often understood as obstacles to patient‐centred care leading to a gap between the ideals and practice. This article proposes that what are often identified in the literature as obstacles can be usefully construed as intrinsic tensions that cannot be eradicated. It offers a theoretical framework for exploring the tensions that builds on Bakhtin’s theory of dialogue and Foucault’s theory of power/knowledge. The framework is designed to ‘unpack’ the tensional, context‐specific nature of ‘patient‐centredness’ through empirical exploration of how particular forms of ‘patient‐centredness’ are produced through tensional meaning‐making in particular contexts. The use of the framework is illustrated in an analysis of how ‘patient‐centredness’ is ascribed specific meanings and enacted in collaborative telephone counselling conversations in a Danish patient‐centred programme entitled ‘Active Patient Support’. The analysis shows how the interweaving of genres and voices works to manage the patient’s uncertainty in ways that both empower and self‐discipline the patient. The discussion explores the implications of the specific form of ‘patient‐centredness’ articulated in the conversations with respect to patient empowerment and participation. It also critically reflects on the theoretical framework as a reflexive approach to tackling the tensions in ‘patient‐centredness’.
In a vigilant state of chronic disruption: how parents with a young child with type 1 diabetes negotiate events and moments of uncertainty
Authors: Kingod Natasja , Grabowski Dan 
Published: June 2020

AbstractLiving as a parent and self‐care surrogate of a young child with type 1 diabetes (T1D) is demanding and a disruption to ‘normal’ routinised daily living. Research has mainly focused on the time of diagnosis as a one‐time biographical disruption. In this article, we will show how, in the case of families with young children with T1D, the biographical disruption can be viewed as a continuous state of vigilance that affects family functioning and ‘normal’ living. We will show this by focusing on the temporal events and moments that keep the families in a state of what we will term ‘chronic disruption’. The events are the transitions from hospitalisation to home, home to nursery, nursery to daycare, and daycare to school and preparations for social activities concerning the child. The moments are more fluid, ranging from daily interruptions when daycare workers and teachers call parents with doubts about self‐care to negotiations with institutions and municipalities and a constant state of worry.
Does asset location and concentration explain REIT IPO valuation?
Authors: Ling David C. , Marcato Gianluca , Zheng Chen 
Published: June 2020

AbstractFollowing recent developments in the asset pricing literature on geographic concentration, we complement classic theories based on information asymmetry and explain the short‐run performance of real estate investment trust (REIT) initial public offerings (IPOs) through an investor base mechanism. We analyze the U.S. market and show that issuers are more likely to underprice when a REIT is more geographically concentrated. In particular, by adopting an identification strategy of pre‐ and post‐IPO returns, we find evidence for an investor base channel rather than a diversification discount channel. In addition, geographic portfolio concentration has a stronger impact on the initial returns of REIT IPOs than property type concentration. Finally, we find that lower deadweight costs at the time of an IPO weaken the influence of geographic concentration on initial returns. Our results are robust to the firm's geographic concentration in economically defined regions, different measures of deadweight costs, the control of information environment of the portfolio and headquarters markets, and to controlling for the REIT's property type focus.
Not All Is Lost for Relapsers: Relapsers With Low WHO Risk Drinking Levels and Complete Abstainers Have Comparable Regional Gray Matter Volumes
Authors: Meyerhoff Dieter J. , Durazzo Timothy C. 
Published: June 2020

BackgroundReductions in substance use are associated with positive long‐term treatment outcomes such as psychosocial functioning; substance use–related consequences; and mental, physical, and neurobiological health. Therefore, nonabstinent clinical trial endpoints have received growing attention from substance abuse treatment experts. Regional brain tissue volumes in alcoholism treatment seekers increase during abstinence, in parallel to cognitive performance.MethodsWe examined the relationships of drinking levels in those who did not maintain abstinence after treatment with magnetic resonance imaging‐derived gray matter (GM) volumes measured 8 months after baseline assessments while in outpatient treatment. The complex drinking behavior during the interval was operationalized as World Health Organization risk drinking levels (WHO‐RDL), derived from the number of standard alcoholic drinks per day. We compared the volumes of addiction‐relevant cortical and subcortical brain regions at long‐term follow‐up among abstainers and 2 groups of relapsers with low and higher WHO‐RDL.ResultsWe found that: (i) relapsers with low WHO‐RDL at follow‐up, who as a group had reduced their risk levels by 2.8 units (by consuming <40 g of ethanol per day over the recovery interval), had regional brain tissue volumes indistinguishable from those of abstainers tested after the same time period and that (ii) relapsers with higher WHO‐RDL, with only 1.2 units average risk‐level reductions, had significantly smaller frontal GM and thalamic volumes than abstainers and relapsers with low WHO‐RDL. Despite many drinking days during recovery, including several with >10 drinks per day, relapsers with low WHO‐RDL at follow‐up tended to perform better than those with higher WHO‐RDL on cognitive domains of working memory and visuospatial skills assessed over the recovery interval.ConclusionsNonabstinent recovery is characterized by addiction‐relevant GM volumes comparable to those of complete abstainers. The WHO‐RDL has meaningful structural neuroimaging correlates potentially suitable as cognitively relevant biomarkers of treatment response and general brain health, perhaps even as objective clinical trial endpoints.
Duration of adhesion of swallowed alginates to distal oesophageal mucosa: implications for topical therapy of oesophageal diseases
Authors: Sonmez Shirley , Coyle Cathal , Sifrim Daniel , Woodland Philip 
Published: June 2020

SummaryBackgroundWe have previously shown, ex vivo, that alginate solutions can have a topical protective effect on oesophageal mucosal biopsies exposed to simulated gastric juice. Oesophageal mucosal impedance can measure the duration of mucosal adherence of ionic solutions since the impedance drops when the solution is present, and rises to baseline as the solution clears.AimTo investigate the in vivo duration of adhesion of swallowed alginate solution to distal oesophageal mucosa.MethodsWe studied 20 healthy volunteers and 10 patients with heartburn. A pH‐impedance catheter was inserted, and baseline distal channel oesophageal impedance measured. Healthy volunteers received 10 mL of either sodium alginate (Gaviscon Advance), Gaviscon placebo (no alginate) or viscous slurry (saline mixed with sucralose), given in a randomised, single‐blinded order over three visits. Patients received either sodium alginate or placebo on two visits. Initial impedance drop was measured, then 1‐minute mean impedance was measured each minute until ≥75% recovery to baseline.ResultsIn healthy volunteers, sodium alginate adhered to the oesophageal mucosa for longer than placebo or viscous slurry (10.4 [8.7] minutes vs 1.1 [1.6] vs 3.6 [4.0], P < 0.01). In patients, sodium alginate adhered to the oesophageal mucosa for longer than placebo (9.0 (5.4) vs 3.7 (4.1), P < 0.01).ConclusionsSodium alginate solution adhered to the oesophageal mucosa for significantly longer than placebo or viscous slurry. This demonstrates that alginates could confer a protective benefit due to mucoadhesion and can be a basis for further development of topical protectants and for topical drug delivery in oesophageal disease.
Conducting a consensus conference to design a psychology service model for acute mental health wards
Authors: Raphael Jessica , Haddock Gillian , Edge Dawn , Lovell Karina , Bucci Sandra , Winter Rachel , Drake Richard , Price Owen , Berry Katherine 
Published: June 2020

ObjectivesThis paper outlines best practice recommendations for the clinical psychologist's role in inpatient settings and also presents a methodology for deriving evidence‐based recommendations, which may be replicated by health care professionals in other areas of service development.MethodsTwenty‐three, nationally drawn experts, deemed expert by profession and/or experience attended a one‐day conference. Participants were presented with findings from previous research and key unanswered questions in terms of how psychological services should be delivered in inpatient settings. Participants discussed the information presented within small groups and then independently responded to the questions posed. Responses to questions either involved ranking priorities or choosing the best possible option in terms of what or how aspects of the model should be delivered.ResultsWe were able to identify referral priorities for formulation, nurse‐led psychosocial interventions and psychological therapy using ranking questions. Consensus (defined as 70% agreement) was achieved within 1–3 voting rounds for all questions which involved selecting one of a range of possible options. These responses provided information about how to deliver formulation, supervision of nurse‐led psychosocial interventions, staff well‐being interventions, and one‐to‐one therapy, as well as psychologists' own training and supervisions needs.ConclusionsFindings provide recommendations relating to five different service areas for inpatient settings seeking to implement a psychological service model: formulation, nurse‐led interventions, one‐to‐one therapy, staff well‐being, and psychologist training and supervision. Additionally, we showcase a methodology for synthesizing knowledge and decision‐making that can be implemented by researchers and health care professionals seeking to design interventions or service models in other settings.Practitioner points

Psychologists working on inpatient wards should endeavour to develop a team formulation for each patient, prioritizing patients with longer length of stay, repeated admissions, and who staff find challenging.
Psychologists should offer 1:1 therapy with patients who have complex needs that cannot be addressed by nurse‐led interventions.
Reflective practice sessions should be a key component of the psychologist's role on inpatient wards with the function of improving staff well‐being.
Consensus conferences are useful methodology to synthesize knowledge and undertaking decision‐making in relation to the design of interventions or service models.