bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimyotoxic Activity of Synthetic Peptides Derived from Bothrops atrox Snake Gamma Phospholipase A2 Inhibitor Selected by Virtual Screening
Authors: Sobrinho J.C. , Francisco A.F. , Simões-Silva R. , Kayano A.M. , Ruiz Diaz J.J. Alfonso , Garay A.F. Gomez , Arruda A. , Ferreira A.S. , Santos A.P.A. , Luiz M.B. , Teles C.B.G. , Pereira S.S. , Zanchi F.B. , Calderon L.A. , Zuliani J.P. , Soares A.M. 
Published: October 2019

Background:
Several studies have aimed to identify molecules that inhibit the toxic actions
of snake venom phospholipases A2 (PLA2s). Studies carried out with PLA2 inhibitors (PLIs) have been
shown to be efficient in this assignment.

Objective:
This work aimed to analyze the interaction of peptides derived from Bothrops atrox PLIγ
(atPLIγ) with a PLA2 and to evaluate the ability of these peptides to reduce phospholipase and myotoxic
activities.

Methods:
Peptides were subjected to molecular docking with a homologous Lys49 PLA2 from B. atrox
venom modeled by homology. Phospholipase activity neutralization assay was performed with BthTX-II
and different ratios of the peptides. A catalytically active and an inactive PLA2 were purified from the B.
atrox venom and used together in the in vitro myotoxic activity neutralization experiments with the peptides.

Results:
The peptides interacted with amino acids near the PLA2 hydrophobic channel and the loop that
would be bound to calcium in Asp49 PLA2. They were able to reduce phospholipase activity and peptides
DFCHNV and ATHEE reached the highest reduction levels, being these two peptides the best that
also interacted in the in silico experiments. The peptides reduced the myotubes cell damage with a highlight
for the DFCHNV peptide, which reduced by about 65%. It has been suggested that myotoxic activity
reduction is related to the sites occupied in the PLA2 structure, which could corroborate the results
observed in molecular docking.

Conclusion:
This study should contribute to the investigation of the potential of PLIs to inhibit the toxic
effects of PLA2s.
rs3851179G>A in PICALM is Protective Against Alzheimer’s Disease in Five Different Countries Surrounding the Mediterranean
Authors: Masri Inas , Salami Ali , El Shamieh Said , Bissar-Tadmouri Nisrine 
Published: October 2019

Background::
Alzheimer’s Disease (AD) is a multifactorial disease affected by various
factors including genetics. Although APOE is considered the major and strongest genetic risk factor,
other genetic factors such as rs3851179G>A in PICALM have been reported despite that not
being fully clear.

Objective:
We first aimed to investigate the correlation between rs3851179G>A in PICALM and
AD in Lebanese individuals affected with AD. Then, we further investigated its overall effect in
five different populations from the Mediterranean region (Turkey, Italy, Spain, France and ours)
through performing a meta-analysis.

Method:
We investigated the relationship between the rs3851179G>A and AD in 109 Lebanese
individuals (54% affected with AD) using allele-specific PCR. Sanger Sequencing was also used to
verify genotyping.

Results:
Using a multiple logistic regression model adjusted for many covariates, only
rs3851179G>A showed a negative correlation with AD (OR=0.28, P=0.04 and OR=0.07, P=0.01
for GA and AA, respectively). To go further, a meta-analysis was conducted using studies on 3,619
participants from five different populations that belong to countries surrounding the Mediterranean
(Turkey, Italy, Spain, France and ours). The sensitivity test showed no genetic heterogeneity for
rs3851179G>A in the pooled analysis (P=0.44 and I2=0%) and in each individual study (P>0.05).
Using an additive model, our results showed a significant association between rs3851179G>A and
AD (OR=0.91, P=0.003). The funnel plot was a symmetrical inverted funnel and no significant
publication bias was found for our model (P=0.46).

Conclusion:
rs3851179A allele in PICALM tends to have a protective factor against AD in the Mediterranean region.
Efficient Solar Integrated Doubly Fed Induction Generator for Wind Energy Harnessing
Authors: Kumar Arjun , Shivashankar  , Ram Bhagwan S. 
Published: October 2019

Background:
Doubly-Fed Induction Generator (DFIG) is a dual input conventional asynchronous
device connected across both stator and rotor, which also functions as an electrical transducer
consuming up-to 30 % of the generated power during the rotor injection. This is the major
concern with respect to the DFIG in terms of effective power generation.

Methods:
The proposed work provides the solution for this undesirable power loss by connecting
the DFIG with an array of solar Photovoltaic (PV) panel through a conventional direct current bus
using a boost converter. This research setup can work on the basis of indirect vector control algorithms
applied at the rotor and grid converter level in order to maintain the constant DC voltage under
arbitrary conditions.

Results:
Even the variations in voltage and frequency will be controlled with this novel approach. A
simulation model of the 300KW solar PV array and a 2MW DFIG system is developed using
MATLAB/Simulink environment.

Conclusion:
Solar and wind energy sources incorporate Maximum Power Point Tracking (MPPT)
through their control algorithms resulting in the add on 30-80 KW of solar power for rotor injection
compared to the existing system in order to reduce the power rating of the converters and power
consumption from the grid.
Como o novo guideline americano para o diagnóstico de hipertensão afetará a rotina médica?/ How the new American guideline for diagnosis of hypertension will affect the physician routine?
Authors: Maciel de Oliveira Camila , Dos Santos Eli Basílio Alves , Bermude Beatriz Elizabeth Bagatin Veleda , Ferreira Lucille Ribeiro , Tizzot Edison Almeida , Mourao Junior Carlos Alberto 
Published: October 2019

Na tentativa de alterar as taxas de morbimortalidade, em novembro de 2017, foi publicado o novo guidelinepela American Heart Association sugerindo que o limite pressórico para o diagnóstico de hipertensão fosse de 130 mmHg para a pressão arterial sistólica (PAS) (ao invés de 140 mmHg) e 80 mmHg para a pressão arterial diastólica (PAD) (ao invés de 90 mmHg) Trying to change the mobimortaly rates, in November 2017, the new guideline published by American Heart Association suggested that the limit for diagnosis of hypertension would be 130mmHg for systolic blood pressure (instead 140mmHg) and 80mmHg for diastolic blood pressure (instead 90mmHg).
Aspectos epidemiológicos e anatomopatológicos do câncer pulmonar diagnosticado em laboratório de um hospital do Sul de Minas Gerais/ Epidemiological and anatomopathological aspects of lung cancer diagnosed in a laboratory in a hospital in the South of Minas Gerais
Authors: De Souza Cândido Irulegui Roseane , Teodoro Paula Pereira , Koga Tatiane Mitsue 
Published: October 2019

Introdução: O câncer de pulmão é o terceiro mais comum no Brasil e no mundo, depois do câncer de mama e de próstata. Destacam-se, como fatores de risco, tabagismo, sexo, idade, exposição a determinados agentes químicos, fatores genéticos, doenças pulmonares prévias e hábitos alimentares. O objetivo desse estudo é identificar os aspectos epidemiológicos e anatomopatológicos do câncer pulmonar. Métodos: Foram avaliados 180 laudos e prontuários dos pacientes submetidos a biópsia pulmonar no período de janeiro de 2009 a dezembro de 2014. Os dados foram descritos sob a forma de frequência relativa e absoluta. Resultados: Dos 180 laudos e prontuários analisados, 70 (40%) foram positivos para malignidade. Destes os dois tipos histológicos mais comuns foram adenocarcinoma e carcinoma epidermoide. O sexo masculino (54%) foi discretamente mais acometido que o feminino (46%). A faixa etária maior que 65 anos foi a de maior incidência. Não foi possível identificar dados completos acerca do consumo de tabagismo. Conclusão: O câncer pulmonar, nesse estudo, foi mais incidente no sexo masculino, o tipo histológico mais encontrado foi o adenocarcinoma e faixa etária mais acometida foi, principalmente, a mais idosa.Introduction: Lung cancer is the third most common cancer in Brazil and in the world, after breast and prostate cancer. Risk factors include smoking, sex, age, exposure to chemical agents, genetic factors, previous pulmonary diseases and eating habits. The aim of this study is to identify the epidemiological and anatomopathological aspects of lung cancer. Methods: Data were collected from 180 anatomopathological reports and medical records from patients submitted to lung biopsies between January 2009 and December 2014. Data were collected and described as relative and absolute frequency. Results: Among the 180 reports and medical records analyzed, 70 (40%) were positive for malignacy. The two most common histological types were adenocarcinoma and epidermoid carcinoma. Men (54%) were slightly more affected than women (46%). The age group over 65 years old was the most affected. It was not possible to obtain complete data above smoking habits. Conclusion: Lung cancer in this study was more frequent in males, the most common histological type was adenocarcinoma, and the age group affected was the oldest.
Eficácia da hemostasia após cateterismo arterial utilizando torniquete de compressão de artéria radial/ Efficacy of hemostasis after arterial catheterization using Radial Artery Compression Tourniquet
Authors: Souto Jaqueline Pereira , Evangelista Christian Pietro , Hueb Alexandre Ciappina , Cortez Paulo José Oliveira 
Published: October 2019

Introdução: Com o aumento da expectativa de vida há também um consequente aumento das doenças cardiovasculares e de intervenções coronárias percutâneas. Objetivo: Avaliar obtenção de hemostasia após cateterizações arteriais percutâneas, por via radial, utilizando torniquete de compressão de artéria radial (TCAR). Métodos: Foi realizado um estudo observacional, transversal quantitativo, que avaliou 80 prontuários de pacientes submetidos consecutivamente a operações arteriais percutâneas (cateterismo cardíaco com ou sem necessidade de angioplastia) por acesso radial, que utilizaram TCAR da marca COMED®, como técnica para obtenção da hemostasia, baseando-se o protocolo institucional para manuseio e retirada do dispositivo. Resultados: Sessenta e cinco por cento dos pacientes eram do sexo masculino, com média de idade de 63 anos, peso médio de 76,5 Kg. Cinco mil unidades internacionais de heparina não fracionada foram administradas em todos os procedimentos, com doses adicionais em pacientes que foram submetidos à angioplastia. A maioria (88,7%) dos dispositivos foram insuflados com 15 ml de ar após o procedimento e a hemostasia foi obtida em 78,7% dos casos. Conclusão: A obtenção de hemostasia com compressão da artéria pelo TCAR COMED®, e com a técnica realizada seguindo o protocolo da instituição, mostrou-se efetiva, reduzindo o tempo de compressão sugerido pelo fabricante.Introduction: With the increase in life expectancy, there is also a consequent increase in cardiovascular diseases and percutaneous coronary interventions. Objective: To evaluate hemostasis after radial percutaneous arterial catheterization using the radial artery compression tourniquet (RACT). Methods: An observational, cross-sectional quantitative study was carried out to evaluate 80 medical records of patients consecutively submitted to percutaneous arterial surgeries (cardiac catheterization with or without angioplasty) by radial access using COMED® RACT as the technique to obtain hemostasis, based on the institutional protocol for device handling and removal. Results: Sixty-five percent of the patients were male, with a mean age of 63 years, mean weight of 76.5 kg. Five thousand international units of unfractionated heparin were administered in all procedures, with additional doses in patients who underwent angioplasty. Most (88.7%) devices were inflated with 15 ml of air after the procedure and hemostasis was obtained in 78.7% of cases. Conclusion: Obtaining hemostasis with compression of the artery by COMED® RACT, and with the technique performed following the protocol of the institution, was effective, reducing the time for compression suggested by the manufacturer.
Reaching People With Disabilities in Underserved Areas Through Digital Interventions: Systematic Review
Authors: Zhou Leming , Parmanto Bambang 
Published: October 2019

BackgroundPeople with disabilities need rehabilitation interventions to improve their physical functioning, mental status, and quality of life. Many rehabilitation interventions can be delivered electronically ("digitally") via telehealth systems. For people with disabilities in underserved areas, electronically delivered rehabilitation interventions may be the only feasible service available for them.ObjectiveThe objective of this study was to evaluate the current status of digital interventions for people with disabilities in remote and underserved areas.MethodsA systematic review was conducted on this topic. Keyword searches in multiple databases (PubMed, CINAHL, and Inspec) were performed to collect articles published in this field. The obtained articles were selected based on our selection criteria. Of the 198 identified articles, 16 duplicates were removed. After a review of the titles and abstracts of the remaining articles, 165 were determined to be irrelevant to this study and were therefore removed. The full texts of the remaining 17 articles were reviewed, and 6 of these articles were removed as being irrelevant to this study. The 11 articles remaining were discussed and summarized by 2 reviewers.ResultsThese 11 studies cover a few types of disabilities, such as developmental disabilities and mobility impairments as well as several types of disability-causing disorders such as stroke, multiple sclerosis, traumatic brain injury, and facio-scapulo-humeral muscular dystrophy. Most of these studies were small-scale case studies and relatively larger-scale cohort studies; the project evaluation methods were mainly pre-post comparison, questionnaires, and interviews. A few studies also performed objective assessment of functional improvement. The intervention technology was mainly videoconferencing. Moreover, 10 of these studies were for people with disabilities in rural areas and 1 was for people in urban communities.ConclusionsA small number of small-scale studies have been conducted on digital interventions for people with disabilities in underserved areas. Although the results reported in these studies were mostly positive, they are not sufficient to prove the effectiveness of telehealth-based digital intervention in improving the situation among people with disabilities because of the small sample sizes and lack of randomized controlled trials.
Improving the Course of Depressive Symptoms After Inpatient Psychotherapy Using Adjunct Web-Based Self-Help: Follow-Up Results of a Randomized Controlled Trial
Authors: Zwerenz Rüdiger , Baumgarten Carlotta , Becker Jan , Tibubos Ana , Siepmann Martin , Knickenberg Rudolf J , Beutel Manfred E 
Published: October 2019

Background
We recently showed in a randomized controlled trial that Web-based self-help as an adjunct improved the effectiveness of multimodal inpatient psychotherapy for depression.

Objective
The aims of this study were (1) to determine whether a Web-based self-help adjunctive to multimodal inpatient psychotherapeutic treatment could also improve the course of depressive symptoms and (2) to identify predictors of residual depressive symptoms at follow-up.

Methods
Overall, 229 patients were randomized either to the Web-based self-help intervention group (Deprexis) or an active control group (Web-based information about depression and depressive symptoms) in addition to multimodal inpatient psychotherapy. Participants in both groups were able to access their respective Web-based programs for 12 weeks, which meant that they typically had access after discharge from the inpatient unit (mean hospitalization duration: 40 days, T1). Follow-up was performed 6 months after study intake (T3).

Results
At follow-up, participants of the Web-based self-help group had considerably lower symptom load regarding depressive symptoms (d=0.58) and anxiety (d=0.46) as well as a better quality of life (d=0.43) and self-esteem (d=0.31) than participants of the control group. Nearly 3 times as many participants of the intervention group compared with the control group achieved remission in accordance with less deterioration. The number needed to treat based on the Beck Depression Inventory-II (BDI-II) improved over time (T1: 7.84, T2: 7.09, and T3: 5.12). Significant outcome predictors were BDI at discharge and treatment group.

Conclusions
Web-based self-help as an add-on to multimodal inpatient psychotherapy improved the short-term course of depressive symptoms beyond termination. Residual symptoms at discharge from inpatient treatment and utilization of the Web-based self-help were the major predictors of depressive symptoms at follow-up. Challenges and barriers (eg, costs, therapists’ concerns, or technical barriers) of adding Web-based interventions to inpatient treatment have to be addressed.

Trial Registration
ClinicalTrials.gov NCT02196896; https://clinicaltrials.gov/ct2/show/NCT02196896.
An Online Survey for Pharmacoepidemiological Investigation (Survey of Non-Medical Use of Prescription Drugs Program): Validation Study
Authors: Black Joshua Curtis , Rockhill Karilynn , Forber Alyssa , Amioka Elise , May K Patrick , Haynes Colleen M , Dasgupta Nabarun , Dart Richard C 
Published: October 2019

BackgroundIn rapidly changing fields such as the study of drug use, the need for accurate and timely data is paramount to properly inform policy and intervention decisions. Trends in drug use can change rapidly by month, and using study designs with flexible modules could present advantages. Timely data from online panels can inform proactive interventions against emerging trends, leading to a faster public response. However, threats to validity from using online panels must be addressed to create accurate estimates.ObjectiveThe objective of this study was to demonstrate a comprehensive methodological approach that optimizes a nonprobability, online opt-in sample to provide timely, accurate national estimates on prevalence of drug use.MethodsThe Survey of Non-Medical Use of Prescription Drugs Program from the Researched Abuse, Diversion and Addiction Related Surveillance (RADARS) System is an online, cross-sectional survey on drug use in the United States, and several best practices were implemented. To optimize final estimates, two best practices were investigated in detail: exclusion of respondents showing careless or improbable responding patterns and calibration of weights. The approach in this work was to cumulatively implement each method, which improved key estimates during the third quarter 2018 survey launch. Cutoffs for five exclusion criteria were tested. Using a series of benchmarks, average relative bias and changes in bias were calculated for 33 different weighting variable combinations.ResultsThere were 148,274 invitations sent to panelists, with 40,021 who initiated the survey (26.99%). After eligibility assessment, 20.23% (29,998/148,274) of the completed questionnaires were available for analysis. A total of 0.52% (157/29,998) of respondents were excluded based on careless or improbable responses; however, these exclusions had larger impacts on lower volume drugs. Number of exclusions applied were negatively correlated to total dispensing volume by drug (Spearman ρ=–.88, P<.001). A weighting scheme including three demographic and two health characteristics reduced average relative bias by 31.2%. After weighting, estimates of drug use decreased, reflecting a weighted sample that had healthier benchmarks than the unweighted sample.ConclusionsOur study illustrates a new approach to using nonprobability online panels to achieve national prevalence estimates for drug abuse. We were able to overcome challenges with using nonprobability internet samples, including misclassification due to improbable responses. Final drug use and health estimates demonstrated concurrent validity to national probability-based drug use and health surveys. Inclusion of multiple best practices cumulatively improved the estimates generated. This method can bridge the information gap when there is a need for prompt, accurate national data.
Sex Differences in Kidney Replacement Therapy Initiation and Maintenance
Authors: Antlanger Marlies , Noordzij Marlies , van de Luijtgaarden Moniek , Carrero Juan Jesus , Palsson Runolfur , Finne Patrik , Hemmelder Marc H. , Aresté-Fosalba Nuria , Reisæter Anna Varberg , Cases Aleix , Traynor Jamie P. , Kramar Reinhard , Massy Ziad , Jager Kitty J. , Hecking Manfred ,   on behalf of the ERA-EDTA Registry
Published: October 2019

Background and objectives
More men than women undergo kidney replacement therapy (KRT) despite a larger number of women being affected by CKD. The aim of this multinational European study was to explore whether there might be historic and geographic trends in sex-specific incidence and prevalence of various KRT modalities.

Design, setting, participants, & measurements
We assessed sex-specific differences in KRT incidence and prevalence using data from nine countries reporting to the European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) Registry for at least 40 years, during the period 1965–2015. Sex distribution data were compared with the European general population (Eurostat). Statistical methodology included basic descriptive statistics, incidence and prevalence calculations per million population (pmp), as well as their male-to-female ratios. Analyses were stratified by age group and diabetic status.

Results
We analyzed data from 230,378 patients receiving KRT (38% women). For all KRT modalities, the incidence and prevalence rates were consistently higher in men than women. For example, the KRT incidence increased from 8 pmp in 1965–1974 to 98 pmp in 2005–2015 in women, whereas it rose from 12 to 173 pmp in men during the same period. Male-to-female ratios, calculated for incident and prevalent KRT patients, increased with age (range 1.2–2.4), showing consistency over decades and for individual countries, despite marked changes in primary kidney disease (diabetes more prevalent than glomerulonephritis in recent decades). The proportion of kidney transplants decreased less with age in incident and prevalent men compared with women on KRT. Stratified analysis of patients who were diabetic versus nondiabetic revealed that the male-to-female ratio was markedly higher for kidney transplantation in patients with diabetes.

Conclusions
Since the beginning of KRT programs reporting to the ERA-EDTA Registry since the 1960s, fewer women than men have received KRT. The relative difference between men and women initiating and undergoing KRT has remained consistent over the last five decades and in all studied countries.
Manejo empírico y emergente del espacio interno de ventas de tiendas de barrio en Bogotá – Luis Marquez
Authors: Márquez Valencia Luis Fernando 
Published: October 2019

El presente artículo buscó conceptualizar desde el pensamiento complejo con observaciones y diálogos cómo se maneja la exhibición y el espacio interno de ventas de un grupo de tiendas de barrio de la Localidad de Barrios Unidos en la ciudad de Bogotá. Partió de los conocimientos y experiencia del autor y del diálogo individual con un grupo de tenderos de la citada Localidad. A través de su propio lenguaje y sus interacciones, para comprender como manejan elobjeto descrito, generando una nueva mirada sobre el asunto. Para ello se usaron métodos cualitativos de investigación y recolección de información, como la observación y las entrevistas de profundidad de donde emergieron varias percepciones, que permiten entender la forma como los tenderos han manejado laexhibición y los espacios internos de ventas de sus tiendas.