bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally invasive methods in pathomorphological assessment with a complete clinical response to neoadjuvant polychemotherapy in breast cancer patients
Authors: Maksimov K. V. , Bagdasarova D. V. , Leukhina I. А. , Mazo M. L. , Surkova V. S. , Gerasimov A. N. , Rozhkova N. I. , Volchenko N. N. , Kaprin A. D. , Zikiryakhodzhaev A. D. 
Published: December 2024

Purpose of the study. To evaluate and compare the diagnostic significance of vacuum‑ assisted biopsy (VAB) and multifocal trepan biopsy (MTB) methods based on a pathomorphological study of postoperative material in patients diagnosed with breast cancer (BC) in all molecular biological types after neoadjuvant polychemotherapy (NAPCT) with a complete clinical response (cCR). Patients and methods. The study included 70 patients with cT1–3N0–3M0 breast cancer with different molecular biological types after NAPCT. It was conducted at the P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre from 2021 to 2023. All patients underwent ultrasound and digital mammography before andafter NAPСT to assess the clinical response to treatment. MTB was performed in 35 patients, VAB in 35 patients, followed by surgical treatment. Histological findings obtained by VAB and MTB and surgical material were compared to assess the pathomorphological response of the tumor to treatment. Results. According to the pathomorphological conclusion, the following results were obtained during the VAB: 1 – truly positive, 29 – truly negative, 3 – falsely negative, 0 – falsely positive. The overall sensitivity of the technique was 25.0 % (CI 6.8–60.2 %); specificity – 100 % (CI 88.1–100 %); false negative result (presence of tumor cells in the surgical material and negative result of VAB) – 9.1 % (CI 3.4–20.2 %); false positive result (absence of tumor cells in the surgical material and a positive result of VAB) – 0 % (CI 0–10.6 %). The overall diagnostic accuracy of the method was 90.9 % (CI 79.8–96.6 %). According to the pathomorphological study, the following was obtained during the MTB: 1 – true positive, 17 – true negative, 5 – false negative and 0 – false positive results. The overall sensitivity of the technique was 16.7 % (CI: 4.3–45.9 %); specificity – (100.0 % CI: 80.5–99.9 %). The false negative result was 23.8 % (CI: 11.3–41.9 %). The false positive result is 0 %. The overall diagnostic accuracy of the method was 78.3 % (CI: 61.2–89.7 %). Conclusion. The results of the study indicate a higher sensitivity of the VAB method compared to MTB in assessing the pathomorphological response of breast cancer patients after antitumor drug treatment, which shows a vector for conducting large prospective studies of this method.
Pathomorphological and pathohistological characteristics of vulvar cancer associated with lichen sclerosus
Authors: Sovpel O. V. , Malik A. V. , Strelchenko Yu. I. , Sovpel I. V. , Mikhailichenko V. Yu. , Parshin D. S. 
Published: December 2024

Purpose of the study. To study the pathomorphological and pathophysiological characteristics of vulvar cancer associated with sclerosing lichen. Patients and methods. The study included 73 patients who underwent examination and treatment at the G. V. Bondar Republican Cancer Center in the period from 2002 to 2019. We performed a comprehensive morphological study, including an assessment of the specific volume of microhemocirculatory vessels and cellular infiltrates. Results. The tumor was most often localized in the area of the labia majora (57.5 %), with affected of the clitoris (12.3 %) and urethra (6.8 %), sometimes affecting both the labia minora and labia majora (23.3 %). Macroscopically, the infiltrative‑ edematous form predominates (63 %), followed by endophytic (20.6 %) and exophytic forms (16.4 %). In patients with invasive vulvar carcinoma associated with lichen sclerosus, undifferentiated types of VIN are often detected: in 52 cases out of 73 observations (71.2 ± 5.3 %). VIN1 was noted in 11 (15.1 ± 4.2 %), VIN2 in 16 (21.9 ± 4.8 %) and VIN3 in 25 (34.2 ± 5.5 %) cases. Thus, in VIN3 associated with LS, the specific volume of vessels was on average 0.1104 ± 0.0103. In well‑differentiated invasive squamous cell carcinoma in patients with LS, this indicator was statistically significantly higher – 0.1677 ± 0.0090 (p < 0.001). The number of cells per 1 mm² of stroma increased with decreasing differentiation degree: 1439 ± 56 in G1, 1550 ± 74 in G2, and 1729 ± 138 in G3. The average number of cells in the field of view also increased: 356 ± 05 in G1, 396 ± 30 in G2, and 520 ± 35 in G3. The specific volume of lymphocytes decreased with increasing tumor malignancy: G1–96.3 ± 2.1 %, G3–78.4 ± 3.9 %. The content of neutrophilic leukocytes and macrophage cells increased: neutrophils, G1–3.3 ± 0.5 %, G3–5.9 ± 0.2 %; macrophages, G1–2.6 ± 0.13 %, G3–4.8 ± 0.3 %. The specific volume of the parenchyma was 0.3501 ± 0.0194 in G1, 0.3711 ± 0.0203 in G2, and 0.4030 ± 0.0219 in G3. The specific volume of the stroma, on the contrary, decreased: G1–0.2052 ± 0.0218, G2–0.1650 ± 0.0206, G3–0.1477 ± 0.0198. Conclusion. The study showed a significant impact of the degree of differentiation of vulvar cancer on the morphological characteristics of the tumor and vessels of the microhemocirculatory bed, which can be used to improve diagnostic and therapeutic approaches.
The Synergistic Effect of Warm Salt Footbath and Foot-Ankle Exercises in Individuals with Type 2 Diabetes Mellitus: A Study Protocol for Multicenter Randomized Controlled Trial
Authors: Sirait Healthy Seventina , Said Faridah Mohd , Mohamad Nur Afiqah 
Published: December 2024

Individuals with type 2 diabetes mellitus (T2DM) experience issues with their sleep quality and elevated level of the neutrophil-lymphocyte ratio (NLR). Warm salt footbaths and foot-ankle exercises play a significant role in addressing inflammation and improving sleep quality. Nevertheless, no studies have examined the synergistic effects of warm salt footbaths and foot-ankle exercises. This study aims to investigate the synergistic effects of warm footbath water and foot-ankle exercises on sleep quality and NLR. A randomized controlled trial with a total of 108 individuals with T2DM randomly assigned to one four groups: a warm salt footbath, a foot-ankle exercises, a combination of both interventions, or a control group. The interventions administered over a period of 4 weeks (three times per week). Evaluations were performed by blinded evaluators at baseline, as well as after 2 and 4 weeks of interventions. Chi-squared test, one-way analysis of variance, and generalized estimating equations were employed for data analysis. The results of this trial were expected to elucidate the synergistic effects of warm salt water footbath and foot-ankle exercises on sleep quality and NLR. Furthermore, the combination of warm salt water footbaths and foot-ankle exercises is more effective either intervention alone or conventional treatment.
Health Literacy and Medication Adherence among Patients with Hypertension
Authors: Lenggogeni Devia Putri , Yeni Fitra , Malini Hema , Anyati Reffy 
Published: December 2024

Hypertension requires patients to adhere to a medication regimen that needs to be adhered to for life to control blood pressure and prevent complications. A related factor to medication adherence is patients' health literacy, which influences their ability to maintain hypertension prescription regimens. This factor is critical in managing chronic diseases, such as hypertension, to achieve optimal health. This study aims to investigate the relationship between health literacy and medication adherence in patients with hypertension. The study was conducted at public health care centers in West Sumatra. This study used a quantitative approach with a cross-sectional design. The researchers used a non-probability sampling technique, namely purposive sampling, for a total sample of 175 respondents. Data were collected using the Morisky Medication Adherence (MMAS-8) and Health Literacy Survey Europe-16 (HLS-EU-Q16) questionnaires. Data were processed using computerization with chi-square test. The results showed that 41.7% of patients with hypertension have sufficient health literacy, and 46.9% have low levels of medication adherence. In addition, 52.3% with inadequate health literacy had low levels of medication adherence. The statistical test results obtained a p-value = 0.001 (p < 0.005), indicating a relationship between health literacy and medication adherence. It is essential to improve hypertension treatment adherence by improving the health literacy of patients with hypertension.
The Cytotoxic Evaluation of Steroids Isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss.
Authors: Riyadi Sandra Amalia , Naini Al Arofatus , Mayanti Tri , Lesmana Ronny , Azmi Mohamad Nurul , Supratman Unang 
Published: December 2024

Dysoxylum alliaceum belongs to the Dysoxylum genus (Meliaceae) and there are few reports concerning the phytochemical components of this plant. To examine the chemical constituents of Dysoxylum alliaceum stem bark, a phytochemical study has been conducted and identified five known steroids, 3β,16β-dihydroxy-24(S)-methyl cholestenol (1), ergosta-5,22-dien-3β-ol (2), ergosta-7,24(28)-dien-3β-ol (3), 22(E)-ergosta-6,22-dien-3β,5α,8α-triol (4), and 20α-dihydroprogesterone (5) from its ethanolic extract. Spectroscopic data such as FT-IR, HR-ESI-MS, 1D, and 2D NMR as well as comparison with previously published spectral data were used to identify the chemical structures of compounds 1–5. Furthermore, these steroids 1-5 were assessed in vitro regarding their cytotoxic effect against A549 lung cancer cell lines and revealed weak to inactive with IC50 values ranging from 68.52 to >150 µM.
Keywords: A549 cell lines, cytotoxic evaluation, Dysoxylum alliaceum (blume) blume ex a.juss, meliaceae, steroid
Rancang bangun smart door double lock menggunakan sensor RFID dan piezoelektrik dengan home security detector berbasis IoT
Authors: Cahyani Ningrum Ayu , Hartono Hartono , Pratiwi Umi 
Published: December 2024

Seiring berkembangnya ilmu pengetahuan dan teknologi, kunci konvensional dinilai semakin tidak efisien. Selain rentan terhadap pembobolan, kunci konvensional juga lebih mudah diduplikat dan kurang praktis. Kekurangan-kekurangan pada sistem kunci konvensional tersebut dapat diatasi dengan beralih ke sistem kunci digital. Peneliti merancang dan membangun sistem smart door double lock yang dapat diakses menggunakan irama ketukan dan NUID pada RFID tag. Kunci pintu ada sistem ini juga diakses menggunakan ponsel android berbasis teknologi IoT. Selain itu, smart door double lock ini juga dapat mendeteksi adanya tindakan pembobolan dan langsung mengirimkan notifikasi kondisi anomali ke ponsel pengguna. Penelitian dilakukan dalam empat tahapan, yaitu persiapan, perancangan sistem, pembangunan sistem, dan pengujian sistem untuk mendapatkan karakterisasi dari sistem yang dibuat. Untuk dapat menghasilkan sistem yang sesuai, tahap perancangan sistem dibagi menjadi beberapa jenis diagram dan desain sistem, meliputi diagram blok, diagram pengkabelan, diagram skematik, desain prototipe 3D, dan desain antarmuka teknologi IoT. Dalam penelitian ini, sistem telah berhasil dibangun dan dapat berjalan dengan karakteristik statik berupa error sebesar 0% dan akurasi serta presisi sebesar 100% sehingga dapat dikatakan bahwa sistem telah berjalan dengan baik. Kebutuhan daya listrik dalam kondisi aktif stand by sebesar 1,788 W – 2,652 W, dan kebutuhan daya listrik ketika sistem aktif bekerja selama ±6 detik sebesar 6,960 W – 8,016 W.
EFEKTIVITAS PERLINDUNGAN HUKUM HAK CIPTA MUSIK YANG DIADAPTASI OLEH DISJOKI UNTUK KONSER BERBAYAR
Authors: Hakim Satria Sulton , . Pranoto 
Published: December 2024

<div class="WordSection1"><p>Artikel ini dilakukan dengan tujuan untuk mengidentifikasi apakah problematika perlindungan hukum musik di Indonesia yang menyebabkan pelanggaran hak cipta tersbut terjadi terus menerus dan bagaimana perlindungan hukum bagi pemegang hak cipta apabila lagunya diadaptasi oleh Disjoki untuk konser berbayar tanpa seiijin pemilik hak cipta. Metode yang digunakan dalam artikel ini adalah penelitian hukum empiris, yaitu suatu penelitian hukum yang dilaksanakan dengan cara meneliti bahan Kemudian, pendekatan yang digunakan penulis dalam artikel ini adalah pendekatan perundang-undangan (<em>statue approach</em>), dan pendekatan konseptual (<em>conceptual approach</em>), dengan jenis data yang terdiri dari data primer dan sekunder. Teknik analisis data yang digunakan yakni berupa reduksi data, penyampaian data dan menarik. Hasil dari penelitian ini adalah pelanggaran terus-menerus terjadi khususnya terkait hak cipta lagu dan/atau musik bidang performing right, dikarenakanbudaya hukum masyarakat Indonesia yang kurang memberikan penghargaan terhadap para pencipta dan karya ciptanya. Kemudian terhadap setiap pelanggaran hak cipta berupa ketiadaan izin tersebut diatas, oleh Undang- undang Hak Cipta telah memberikan perlindungan kepada pencipta berupa gugatan ganti rugi secara perdata serta adanya hak negara untuk melakukan penuntutan secara pidana.</p></div>
IMPLEMENTATION OF THE SETTLEMENT OF MSME BAD LOANS BASED ON POJK NUMBER 11 OF 2020 DUE TO THE COVID-19 PANDEMIC (STUDY AT PT. BANK RAKYAT INDONESIA (PERSERO) TBK SURAKARTA)
Authors: Izdihar Raihan Ade , Imanullah Moch. Najib 
Published: December 2024

<em>This article aims to review legal issues regarding the implementation of the settlement of M</em><em>SME bad loans based on Financial Services Authority (POJK) Regulation Number 11 of </em><em>2020 at PT. Bank Rakyat Indonesia and constraints in the implementation of bad credit settlement due to Covid-19 and alternative solutions. To achieve this goal, then empirical legal research is conducted which is descriptive The data type in this study consists of primary data obtained directly from the field and secondary data obtained from the results of literature study. The primary data collection technique used is to use interview techniques, while secondary data collection techniques use downloading and collecting necessary legal materials. The data analysis techniques used are interactive analysis models. The results of this research and study, show that the implementation of economic recovery policy issued by the government has been applied well by Bank BRI, especially for Micro, Small, and Medium Enterprises (MSMEs) debtors. The form of restructuring conducted by Bank BRI Surakarta is by lowering interest rates and extending the installment period. Government policy by issuing a credit relaxation policy is a very appropriate step, especially for debtors of Micro, Small, and Medium Enterprises or MSMEs of Bank BRI Surakarta. The settlement of bad loans due to the Covid-19 pandemic at Bank BRI Surakarta has been implemented based on The Financial Services Authority (POJK) Regulation Number 11 of 2020 on The Stimulus Impact of Covid-19. An alternative solution to the constraints of the implementation of bad credit settlement due to Covid-19 is the launch of</em> the<em> Economic Recovery Program (PEN) through the Regulation of the Financial Services Authority (POJK) Number 11 of 2020 on Stimulus Impact of Covid-19. State-owned banks, in this case Bank BRI Surakarta has helped MSME debtors affected by Covid-19</em>
PERLINDUNGAN HUKUM BAGI PENERIMA PINJAMAN DALAM MENGGUNAKAN PEER TO PEER LENDING
Authors: Sirait Gabriella Hosianna , Sudarwanto Albertus Sentot 
Published: December 2024

<p>Artikel ini bertujuan untuk mengkaji dan menganalisis perlindungan hukum terhadap penerima pinjaman dalam menggunakan layanan peer to peer lending. Penelitian ini adalah penelitian empiris bersifat deskriptif. Sumber data penelitian ini didapat dengan melakukan wawancara terhadap penerima pinjaman peer to peer lending, penyelenggara peer to peer lending, dan Otoritas Jasa Keuangan. Hasil penelitian menunjukkan bahwa dalam mengajukan pinjaman, penerima pinjaman sering kali merasa dirugikan oleh penyelenggara atau penyedia layananan. Perlindungan hukum yang dapat diperoleh oleh penerima pinjaman yaitu perlindungan hukum secara preventif dan represif. Perlindungan hukum secara preventif bersumber dari Undang-Undang Perlindungan Konsumen,Peraturan Otoritas Jasa Keuangan, dan perlindungan hukum yang berasal dari penyelenggara pinjaman. Perlindungan hukum secara represif yaitu penyelesaian sengketa melalui jalur litigasi maupun non litigasi</p>
Problematic issues of the development of hospital-replacing technologies in surgery at the prehospital stage and ways to solve them
Authors: Vorobyov V. V. , Novikov K. V. , Ovchinnikov D. V. 
Published: December 2024

Introduction. One of the main trends in the development of the healthcare system in the Russian Federation is a shift in the emphasis of care from inpatient to outpatient. At the beginning of 2000, this trend in healthcare was conﬁrmed by its development. However, the position on shifting the center of medical care from the inpatient to the outpatient level is currently not conﬁrmed, in particular, in outpatient surgery.The purpose of the study: to analyze the work of day surgical hospitals and identify problematic issues in the development of hospital-replacement technologies in surgery at the prehospital stage and propose ways to solve them.Materials and methods. The research materials were our own developments based on the results of the work of day surgical hospitals in the outpatient surgery clinic of the Military Medical Academy of S.M. Kirov, as well as statistical data, scientiﬁc works and publications presented in periodicals by the most authoritative representatives of domestic medicine in the ﬁeld of studying the development of hospital-replacement technologies (day surgical hospitals).Results. During the study, it was revealed that the number of surgical interventions performed at the prehospital stage has been progressively decreasing since 2005. The average bed occupancy per year in day hospitals of hospitals and clinics is lower than that of 24-hour hospital beds, which indicates the idleness of day hospital beds and their underutilization. There is a low turnover of day hospital beds. All this conﬁrms the presence of problems and low eﬃciency of day hospitals. To solve problematic issues in the development of hospital-replacement technologies, the authors recommend establishing “normative indicators” for the work of day hospitals, determining the status of a day hospital bed, increasing bed turnover, establishing targeted funding for day hospitals, etc. To improve the system of providing inpatient replacement care at the prehospital stage, it is proposed to create a multidisciplinary center for inpatient replacement technologies. All clinics assigned to the multidisciplinary center for hospital-replacement technologies refer patients who cannot receive routine medical care in the clinic to the multidisciplinary center. The center selects patients who will receive care using hospital-replacement technologies. The remaining patients are sent to hospitals for treatment.Conclusion. In order to increase the eﬃciency of day hospitals, it is necessary to establish standard indicators for their work. It is necessary to increase the turnover of day hospital beds. It is advisable to organize targeted funding for all day hospitals. An option for optimizing the organization of inpatient replacement care at the outpatient stage is the creation of a multidisciplinary center for inpatient replacement technologies, which will prevent the “outﬂow” of outpatients to hospitals and increase the eﬃciency of using day hospital beds.
Medical and social characteristics of doctors recognized as disabled for the first time in the Irkutsk region
Authors: Rybchenko N. V. , Vladimirova O. N. , Afonina K. P. , Butko D. Yu. , Goryainov I. V. 
Published: December 2024

Introduction. The problem of disability of doctors is the most important indicator of public health, since doctors solve an important task of state policy aimed at maintaining public health, which determines the study and analysis of the disability status of this contingent of specialists.The purpose of the study: analysis of factors that shape the medical and social portrait of doctors who have been diagnosed with a disability for the ﬁrst time. Task. To explore the medical and social characteristics of doctors who are ﬁrst recognized as disabled in the Irkutsk region in 2021–2023.Materials and methods. Subject of the study: 400 citizens who were recognized as disabled for the ﬁrst time in the Federal State Institution «Main Bureau of Medical and Social Expertise in the Irkutsk Region» in 2021–2023. Of these, 174 people are doctors. The study is selective. Selection criteria: persons recognized as disabled for the ﬁrst time in the Irkutsk region in 2021–2023, working at the time of examination in their specialty. Sources: form 7-social security. Research methods: documentary, analytical, statistical.Results. In the structure of those ﬁrst recognized as disabled among doctors, women predominate by gender, while men predominate in the control group, and the average age of initial recognition as disabled in the main group is older than in the control group. Most often, the III group of disability is established in the main and control group, the most rarely – I. Three main classes of diseases form more than 75,0% of primary disability in the Irkutsk region, and disability due to malignant neoplasms in the medical contingent is found slightly more often, and due to diseases of the circulatory system – somewhat less often than in the control group. Most often, in the ﬁrst-recognized person in the main and control group, restrictions on the ability to self-service, movement and work in their various combinations were revealed.Conclusion. Among doctors from among the factors that were ﬁrst recognized by people with disabilities, forming their medical and social portrait, were the female gender, the age of 55 years and older, the presence of a «light» group III of disability due to malignant neoplasms. The primary disability of doctors was most often established due to persistent disorders of the function of the blood system and the immune system, with a limitation of the ability to independently maintain, movement and work.
Análisis de videojuegos comerciales para el desarrollo de prácticas científicas y habilidades socioemocionales en la escuela primaria
Authors: Suarez Viviana Irma , Martín Rocio Belen , Occelli Maricel 
Published: December 2024

Con el objetivo de identificar videojuegos comerciales como mediadores para la enseñanza de las ciencias naturales, fortaleciendo prácticas científicas y habilidades socioemocionales, en el segundo ciclo nivel primario, se desarrolla un análisis documental, con la aplicación del modelo construido ad hoc, formando parte de un estudio más amplio. De los resultados se observa en las Dimensiones jugabilidad intrínseca (técnica) y mecánica, que todos pueden ser utilizados en las diferentes plataformas, la mayoría pertenece al género mixto con los objetivos y características dentro de la narrativa y presenta un avatar. En las Dimensiones jugabilidad interactiva- interpersonal y artística- intrapersonal, se detectan entre otros, factores concernientes con las habilidades socioemocionales. La mayoría evidenció la presencia de recompensas intrínsecas (habilidad de relacionarse y autonomía) y extrínsecas. En referencia a percepciones del jugador, escenario y sentimientos que se desencadenan: satisfacción, inmersión, etc. la mayoría de estos videojuegos los promueve con escenarios de realidad autogenerada y en primera persona. La Dimensión didáctica: prácticas científicas en su categoría indagación admiten observación y manipulación de variables, estimulan la formulación de preguntas, exploración del contexto y emisión de hipótesis/supuestos. En cuanto a la categoría modelización, menos de la mitad de los videojuegos representa entidades o fenómenos y en todos los escenarios y narrativas favorecerían la argumentación, el uso e identificación de pruebas, justificar acciones y elaborar conclusiones.

Palabras clave: Ciencias de la naturaleza, Afectividad y sentimiento, Aprendizaje, Juego de ordenador