bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Observational Registry of Repository Corticotropin Injection (Acthar® Gel) for the Treatment of Multiple Sclerosis Relapse
Authors: Kaplan Jeffrey , Miller Tamara , Baker Matthew , Due Bryan , Zhao Enxu 
Published: December 2020

Background and Purpose: Effective relapse treatment is critical for minimizing disability in patients with multiple sclerosis (MS). Repository corticotropin injection (RCI; Acthar® Gel) has demonstrated efficacy for the treatment of MS exacerbations. However, there is limited real-world evidence available regarding the relationship between the use of RCI for MS relapses and patient demographics, disease characteristics, and dosing regimens. In this multicenter, prospective, observational registry, patients receiving RCI for acute MS relapse were characterized, and recovery and safety outcomes were described.Methods: Patients were invited by their treating clinician to participate in the registry during a routine care visit. The decision to initiate RCI occurred before determination of study eligibility. All treatment decisions were made at the discretion of the patient's health care provider and were not mandated by the study design or protocol. Each enrolled patient was followed for up to 24 Months or until the date of study termination. The primary endpoint was the change from baseline in MS Impact Scale Version 1 (MSIS-29v1) physical subscale scores at Month 2. Additional assessments included the MSIS-29v1 psychological subscale, Expanded Disability Status Scale (EDSS), Clinical Global Impression of Improvement (CGI-I), Work Productivity and Activity Impairment Questionnaire: MS (WPAI:MS), and Health Resource Utilization (HRU) questionnaire.Results: Of 145 patients enrolled, 82 (56.6%) completed 24 Months of follow-up. Mean MSIS-29v1 physical subscale scores improved at 2 Months (−8.0; P = 0.0002) and 6 Months (−9.6; P &lt; 0.0001). Mean MSIS-29v1 psychological subscale scores also improved at 2 Months (−7.9; P = 0.0040) and 6 Months (−9.9; P = 0.0012). Mean EDSS scores improved at 2 Months (−0.4; P &lt; 0.0001) and 6 Months (−0.5; P &lt; 0.0001). CGI-I scores indicated improvement in 63.4% of 71 patients at 2 Months and 61.4% of 57 patients at 6 Months (both P &lt; 0.0001). Improvements on the WPAI:MS activity impairment domain (P &lt; 0.001) and reductions in outpatient, specialist, and emergency department visits were observed at 2 and 6 Months. A total of 35 (28.0%) patients reported 83 adverse events; 11 (8.8%) patients reported 16 serious adverse events.Conclusions: This observational study found significant improvements in MS assessment scores after RCI treatment and supports the efficacy and tolerability of RCI for MS relapse.Clinical Trial Registration: This trial is registered on ClinicalTrials.gov with the identifier NCT02633033.
Investigation of PolyVinyl Chloride Plastisol Tissue-Mimicking Phantoms for MR- and Ultrasound-Elastography
Authors: Chatelin Simon , Breton Elodie , Arulrajah Ajeethan , Giraudeau Céline , Wach Benoit , Meylheuc Laurence , Vappou Jonathan 
Published: December 2020

Objective: Realistic tissue-mimicking phantoms are essential for the development, the investigation and the calibration of medical imaging techniques and protocols. Because it requires taking both mechanical and imaging properties into account, the development of robust, calibrated phantoms is a major challenge in elastography. Soft polyvinyl chloride gels in a liquid plasticizer (plastisol or PVCP) have been proposed as soft tissue-mimicking phantoms (TMP) for elasticity imaging. PVCP phantoms are relatively low-cost and can be easily stored over long time periods without any specific requirements. In this work, the preparation of a PVCP gel phantom for both MR and ultrasound-elastography is proposed and its acoustic, NMR and mechanical properties are studied.Materials and methods: The acoustic and magnetic resonance imaging properties of PVCP are measured for different mass ratios between ultrasound speckle particles and PVCP solution, and between resin and plasticizer. The linear mechanical properties of plastisol samples are then investigated over time using not only indentation tests, but also MR and ultrasound-elastography clinical protocols. These properties are compared to typical values reported for biological soft tissues and to the values found in the literature for PVCP gels.Results and conclusions: After a period of two weeks, the mechanical properties of the plastisol samples measured with indentation testing are stable for at least the following 4 weeks (end of follow-up period 43 days after gelation-fusion). Neither the mechanical nor the NMR properties of plastisol gels were found to be affected by the addition of cellulose as acoustic speckle. Mechanical properties of the proposed gels were successfully characterized by clinical, commercially-available MR Elastography and sonoelastography protocols. PVCP with a mass ratio of ultrasound speckle particles of 0.6%–0.8% and a mass ratio between resin and plasticizer between 50 and 70% appears as a good TMP candidate that can be used with both MR and ultrasound-based elastography methods.
Neuropsychological Subgroups of Emotion Processing in Youths With Conduct Disorder
Authors: Kohls Gregor , Fairchild Graeme , Bernhard Anka , Martinelli Anne , Smaragdi Areti , Gonzalez-Madruga Karen , Wells Amy , Rogers Jack C. , Pauli Ruth , Oldenhof Helena , Jansen Lucres , Rhijn Arthur van , Kersten Linda , Alfano Janine , Baumann Sarah , Herpertz-Dahlmann Beate , Vetro Agnes , Lazaratou Helen , Hervas Amaia , Fernández-Rivas Aranzazu , Popma Arne , Stadler Christina , De Brito Stephane A. , Freitag Christine M. , Konrad Kerstin 
Published: December 2020

Background: At the group level, youths with conduct disorder (CD) show deficient emotion processing across various tasks compared to typically developing controls (TDC). But little is known about neuropsychological subgroups within the CD population, the clinical correlates of emotion processing deficits [for instance, with regard to the presence or absence of the DSM-5 Limited Prosocial Emotions (LPE) specifier], and associated risk factors.Methods: 542 children and adolescents with CD (317 girls) and 710 TDCs (479 girls), aged 9–18 years, were included from the FemNAT-CD multisite study. All participants completed three neuropsychological tasks assessing emotion recognition, emotion learning, and emotion regulation. We used a self-report measure of callous-unemotional traits to create a proxy for the LPE specifier.Results: Relative to TDCs, youths with CD as a group performed worse in all three emotion domains. But using clinically based cut-off scores, we found poor emotion recognition skills in only 23% of the participants with CD, followed by emotion regulation deficits in 18%, and emotion learning deficits in 13% of the CD group. Critically, the majority of youths with CD (~56%) did not demonstrate any meaningful neuropsychological deficit, and only a very small proportion showed pervasive deficits across all three domains (~1%). Further analyses indicate that established DSM-5 subtypes of CD are not tightly linked to neurocognitive deficits in one particular emotion domain over another (i.e., emotion recognition deficits in CD+LPE vs. emotion regulation deficits in CD–LPE).Conclusions: Findings from this large-scale data set suggest substantial neuropsychological diversity in emotion processing in the CD population and, consequently, only a subgroup of youths with CD are likely to benefit from additional behavioral interventions specifically targeting emotion processing mechanisms.
Implementing Organizational WHP Into Practice: Obstructing Paradoxes in the Alignment and Distribution of Empowerment
Authors: Skagert Katrin , Dellve Lotta 
Published: December 2020

Background: According to policy and theory, there is need for organizational workplace health promotion (WHP) to strengthen working conditions for all employees. However, earlier studies show it is hard to implement in practice. The aim was to critically analyze and identify interacting mechanisms and obstacles behind failures of organizational WHP projects from system perspectives.Methods: A holistic case study was performed, to critically analyze data from an organizational WHP project approach at a public health care organization. The qualitative data was collected over 5 years and included interviews with key actors (n = 80), focus groups (n = 59 managers), structured observations (n = 250 hours), continuous field observations and documents (n = 180). Questionnaires to employees (n = 2,974) and managers (n = 140) was complementing the qualitative-driven mixed method approach.Results: The analysis shows obstructing paradoxes of alignment and distribution of empowerment during the process of implementation into practice. The obstacles were interacting over system levels and were identified as: Governance by logics of distancing and detaching, No binding regulation of WHP, Separated responsibility of results, Narrow focus on delegated responsibilities, Store-fronting a strategic model, Keeping poor organizational preconditions and support for developments and Isolate WHP from other organizational developments.Conclusions: The following premises can be formulated regarding successful organizational WHP programs. Consider (1) the uncertainty a distributed empowerment to all system levels may create; (2) the distributed impact to define the target and allow broader areas to be included in WHP; and (3) the integration into other development processes and not reducing the organizational WHP to the form of a project.
Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis
Authors: Lee Dong Hwan , Kim Min Ji , Lee Il Jae , Park Dong Ha 
Published: December 2020

Background: Malignant melanoma is the most serious type of skin cancer, and its incidence rate increases with age. Malignant melanoma in infants has been rarely reported in the literature. Herein, we report a case of malignant transformation of a nodular lesion found in the penis of a patient with a giant congenital nevus.Case presentation: A 1-month-old male patient was admitted due to the presence of a giant congenital nevus involving the lower abdomen, bilateral inguinal areas, genitals, and left thigh and knee. Six months later, nodules measuring 1 cm in diameter protruding from the genital area were noted, and a part of the nodule was removed via elliptical excision with the patient under general anesthesia. Gross examination showed an edematous lesion similar to a neurofibroma and with unclear boundaries. Biopsy revealed a malignant melanoma, with a Breslow thickness of at least 3 mm, and absence of lymphovascular invasion; the biopsy confirmed incomplete excision. The patient was scheduled for radical resection, but reconstruction was not performed following surgical resection due to the guardian's refusal. Hence, the patient only received an adjuvant medical treatment and eventually died.Conclusion: We reported a rare case of an infant with a malignant melanoma in the penis. Congenital malignant melanoma rarely occurs in infants; however, due to its fatal consequences, follow-up should be performed to assess for malignant changes.
Measuring the complexity of general practice consultations: a Delphi and cross-sectional study in English primary care
Authors: Salisbury Chris , Lay-Flurrie Sarah , Bankhead Clare R , Fuller Alice , Murphy Mairead , Caddick Barbara , Ordóñez-Mena José M , Holt Tim , Nicholson Brian D , Perera Rafael , Hobbs FD Richard 
Published: December 2020

BackgroundThe complexity of general practice consultations may be increasing and varies in different settings. A measure of complexity is required to test these hypotheses.AimTo develop a valid measure of general practice consultation complexity applicable to routine medical records.Design and settingDelphi study to select potential indicators of complexity followed by a cross-sectional study in English general practices to develop and validate a complexity measure.MethodThe online Delphi study over two rounds identified potential indicators of consultation complexity. The cross-sectional study used an age–sex stratified random sample of patients and general practice face-to-face consultations from 2013/2014 in the Clinical Practice Research Datalink. The authors explored independent relationships between each indicator and consultation duration using mixed-effects regression models, and revalidated findings using data from 2017/2018. The proportion of complex consultations in different age–sex groups was assessed.ResultsA total of 32 GPs participated in the Delphi study. The Delphi panel endorsed 34 of 45 possible complexity indicators after two rounds. After excluding factors because of low prevalence or confounding, 17 indicators were retained in the cross-sectional study. The study used data from 173 130 patients and 725 616 face-to-face GP consultations. On defining complexity as the presence of any of these 17 factors, 308 370 consultations (42.5%) were found to be complex. Mean duration of complex consultations was 10.49 minutes, compared to 9.64 minutes for non-complex consultations. The proportion of complex consultations was similar in males and females but increased with age.ConclusionThe present consultation complexity measure has face and construct validity. It may be useful for research, management and policy, and for informing decisions about the range of resources needed in different practices.
Hubungan Kebiasaan Merokok di dalam Rumah dengan Kejadian Pneumonia pada Anak Usia 1-4 Tahun
Authors: Wahyuni Nuniek Tri , Aeni Heni Fa'riatul , Azizudin Muhammad 
Published: December 2020

ABSTRAK Pneumonia merupakan penyebab dari 15% kematian pada balita. Keberadaan anggota keluarga yang merokok di dalam rumah merupakan salah satu faktor penyebab terjadinya masalah kesehatan pada sistem pernafasan khususnya Pneumonia pada anak. Tujuan penelitian ini adalah untuk mengetahui hubungan kebiasaan merokok di dalam rumah dengan kejadian Pneumonia pada anak usia 1-4 tahun. Jenis penelitian ini adalah penelitian analitik dengan pendekatan cross sectional. Populasi penelitian ini adalah anggota keluarga yang memiliki anak usia 1-4 tahun yang terkena Pneumonia sebanyak 110 dengan jumlah sampel 86 responden menggunakan accidental sampling. Pengumpulan data diperoleh dengan menggunakan kuesioner dan dianalisis secara statistik menggunakan uji Chi Square. Berdasarkan hasil uji statistik dari 86 responden yang memiliki keberadaan orang yang merokok di dalam rumah sebanyak 52 orang (60,47%) sedangkan keberadaan orang yang tidak merokok di dalam rumah sebanyak 34 (39,53%). Responden dengan kategori mengalami Pneumonia sebanyak 75 orang (87,21%), yang mengalami Pneumonia berat sebanyak 7 orang (8,14%) dan yang mengalami Pneumonia sangat berat sebanyak 4 orang (4,63 %) dengan P value = 0,016 (< 0,05). Terdapat hubungan kebiasaan merokok dengan kejadian Pneumonia pada anak usia 1-4 tahun. Kata kunci : kebiasaan merokok; pneumonia; anak CORRELATION BETWEEN SMOKING HABITS AT HOME AND THE INCIDENT OF PNEUMONIA AMONG CHILDREN AGED 1-4 YEARS ABSTRACT Pneumonia is the cause of 15% of deaths in children under five. The presence of family members who smoke in the house is one of the causal factors of health problems in the respiratory system, especially pneumonia among children. This study was aimed to determine the correlation between smoking habits at home and the incidence of pneumonia among children aged 1-4 years. This was an analytic study with cross sectional approach. The population of this study were family members who had children aged 1-4 years with pneumonia as many as 110 people. The number of samples was taken through the Slovin sample size formula totally 86 respondents and the determination of the samples used Accidental Sampling. Data were collected using a questionnaire and analyzed statistically using the Chis Square test. Based on the results of statistical tests, it was revealed that of 86 respondents, 52 people (60.47%) had the presence of people who smoked in the house while 34 (39.53%) did not have had the presence of people who smoked in the house. 75 respondents (87.21%) had pneumonia, 7 people experienced severe pneumonia (8.14%) and 4 people experienced very severe pneumonia (4.63%). Chi Square test results obtained a P value=0.016 (<0.05), which meant that there is a relationship between smoking habit at home and the incidence of pneumonia among children aged 1-4 years. Keywords: Smoking habit; pneumonia; children
Pengaruh Faktor-Faktor Produksi Terhadap Produktivitas Usaha Tani Padi Sawah di Kelurahan Ngkari-Ngkari Kecamatan Bungi Kota Baubau
Authors: Zarliani Waode Al 
Published: December 2020

Tujuan penelitian ini (1) untuk mengetahui pengaruh luas lahan, bibit, tenaga kerja, pupuk, dan pestisida secara simultan terhadap produktivitas usaha tani padi sawah; dan (2) untuk mengetahui pengaruh luas lahan, bibit, tenaga kerja, pupuk, pestisida dan terhadap produktivitas usaha tani padi sawah. Populasi dalam penelitian ini adalah keseluruhan petani yang mengusahakan tanaman padi sawah yang berjumlah 470 orang. Penentuan sampel dilakukan dengan metode simple random sampling dengan mengambil 10% dari populasi, sehingga diperoleh jumlah sampel 47 responden. Selanjutnya data ditabulasi dan dianalisis dengan teknik analisis regresi linear berganda. Hasil penelitian diperoleh bahwa terdapat pengaruh Faktor-faktor produksi secara simultan terhadap produktifitas pada usahatani padi sawah dengan pengaruh sebesar 75,9% dan selebihnya 24,1%% dipengaruhi oleh faktor lain. Nilai signifikansi lahan (X1) = 0,009, bibit (X2)=0,040, Jumlah tenaga kerja (X3) =0,981, Pupuk (X4)=0,013, pestisida X5= 0.000. dari hasil tersebut, tenaga kerja tidak berpengaruh signifikan sedangkan luas lahan, bibit,pupuk dan pestisida berpengaruh signifikan terhadap produktivitas usaha tani padi sawah dengan persamaan Regresi Y= 1370,989 -802,119 X1 + 11,107 X2 -101 X3 + 1.010 X4 + 519,958 X5 + e.
Effect of Downstream Expansion of a Long-Throated Flume on Flow Properties
Authors: HATİPOĞLU Murat , GÖĞÜS Mustafa , UÇAR Muhammed 
Published: December 2020

Long throated flumes are widely used flow measurement devices that not requiring site-specific level to flow curves and therefore laboratory experiments. In this study, downstream expansion effect of the long throated flumes with rectangular cross section were analysed for the dimensionless parameters derived from Buckingham’s pi theorem and some other known hydraulic quantities such as discharge coefficient, approach velocity coefficient, submergence ratio of the flow etc. Therefore, five downstream transitions with different expansion angles were tested. In each test, the critical depth yc, the flow head at the depth measurement section h1, minimum required energy dissipater length Lt and the head after hydraulic jump y2 were measured for both modular and free flow conditions. The relation of hydraulic quantities of calculated dimensionless parameters with relevant parameters; modular limits, approach velocity coefficients and discharge coefficients etc. were graphed to represent the design relationships for long throated flumes.Long throated flumes are widely used flow measurement devices that not requiring site-specific level to flow curves and therefore laboratory experiments. In this study, downstream expansion effect of the long throated flumes with rectangular cross section were analysed for the dimensionless parameters derived from Buckingham’s pi theorem and some other known hydraulic quantities such as discharge coefficient, approach velocity coefficient, submergence ratio of the flow etc. Therefore, five downstream transitions with different expansion angles were tested. In each test, the critical depth yc, the flow head at the depth measurement section h1, minimum required energy dissipater length Lt and the head after hydraulic jump y2 were measured for both modular and free flow conditions. The relation of hydraulic quantities of calculated dimensionless parameters with relevant parameters; modular limits, approach velocity coefficients and discharge coefficients etc. were graphed to represent the design relationships for long throated flumes.
A Análise do discurso e lugares do dizer – topoi e tropismos em tempos de resistência política: o caso Georg Floyd Discourse Analyses and spech´s place – topies and tropisms in time of politic resistence: the case Georg Floyd
Authors: Carreira Rosangela , Chaves Ramon 
Published: December 2020

RESUMO
Este artigo tem por objetivo analisar os lugares do dizer na sociedade, partindo das concepções topológico-discursivas trazidas por Maingueneau (2006, 2008 e 2010) e ampliadas estudos sobre discurso da negritude e identidade negra. Davis (2015) no que concerne à relação resistência e classe; Buttler (2017) e Goffman (2012) no que fiz respeito a concepções relativas aos corpos dos sujeitos e Courtine (2014) e Foucault (1984 e 2000) aos aspectos relacionados ao discurso político e enfrentamentos para compreensão de tropismos discursivos. Trata-se de uma pesquisa de ordem interpretativa orientada pela Análise do Discurso (AD). Para isso, apresenta uma análise sobre lugares do dizer e condições sócio-históricas de produção, tendo como norte e objeto de análise o caso Georg Floyd cujas cenas de enunciação apresentam elementos (para)tópicos, atópicos e tropismos em movimentos discursivos que consolidam ações de resistência política.

Palavras-chave: Paratopia. Corpo. Negro. Resistência. Discurso
Experiencias educativas y pandemia, una reflexión desde la Cibercultur@
Authors: González Morales Laura , López López Guilebaldo Fermín Fermín 
Published: December 2020

En este artículo se propone un ejercicio de análisis sobre los procesos de organización que se han generado en el ámbito educativo en regiones de América Latina que se caracterizan por una alta marginación, a partir de la experiencia de emergencia sanitaria por la pandemia de COVID-19, provocada por el virus SARS-CoV-2, desde algunos planteamientos contemporáneos de la comunicación para el desarrollo como la comunicación para el cambio social, la cibercultur@, la ingeniería social de la comunicación y la cultura de participación. El artículo está organizado en tres partes, la primera presenta de manera general el perfil de la propuesta latinoamericana de la comunicación para el desarrollo que comienza en la década de los años setenta del siglo xx. En la segunda, se mencionan algunas características de las sociedades urbanas que han ido configurando su sistema de información a partir de la relación que establecen con los medios de comunicación tradicionales y nuevos medios, y en la parte final se esboza el trazo de una propuesta de análisis que permitió identificar los modos de actuación en el ámbito educativo en situaciones materiales poco favorables.
Food as a Nonverbal Communication System
Authors: M. Fayer Joan , Ferri Joseph M. , Simounet de Géigel Alma , Boero de Peters Amalia 
Published: December 2020

Abstract/short description:
This study presents a cross-region comparison of the food cultures of Puerto Rico, Dominican Republic and United States of America. The food is here conceptualized as a non-verbal communication system and Barthes' structural model is used for its analysis and comparison. The authors observe that food can indicate social status, religion, gender, age and geographical origins. Also, they observe that in the regions where different cultures are in contact, their cuisines can often mix with each other.
Short description written by Michał Gilewski