bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carboplatin dose capping affects pCR rate in HER2-positive breast cancer patients treated with neoadjuvant Docetaxel, Carboplatin, Trastuzumab, Pertuzumab (TCHP)
Authors: Howell Sacha J. , Coe Faye , Wang Xin , Horsley Laura , Ekholm Maria 
Published: August 2020

Abstract
Purpose
Estimated glomerular filtration rate (eGFR) is commonly used to calculate carboplatin doses and capping the eGFR may be used to reduce the risk of excessive dosing and toxicity. We sought to retrospectively examine the impact of our carboplatin guidelines on pathological complete response rates (pCR) and toxicity in women with HER2+ breast cancer receiving neoadjuvant docetaxel, carboplatin, trastuzumab and pertuzumab (TCHP).

Methods
The delivered area under the curve (dAUC) was calculated [(actual carboplatin dose at cycle 1 ÷ dose calculated with uncapped/unbanded eGFR) × 6] and dichotomized at the median value. The impact of this and other clinical factors on pCR rate, dose intensity (DI) and toxicity was assessed.

Results
124 eligible patients were identified of whom 63.7% (79/124) achieved pCR. The median dAUC at cycle 1 was 5.75 mg × ml/min. Those with lower dAUC were more frequently younger and overweight/obese. Patients with lower dAUC had significantly inferior pCR rates of 54.8% (34/62) vs 72.6% (45/62), respectively (p = 0.040). Similar results were seen in the ER+ subgroup; 45.2% (19/42) vs 68.3% (28/41), p = 0.037%, whereas no significant difference was seen among ER- patients; 75.0% (15/20) vs 81.0% (17/21), p = 0.72. DI and toxicity were comparable between the two dAUC groups.

Conclusions
The overall pCR rate was high in patients with HER2+ breast cancer receiving the TCHP regimen; however, carboplatin dose capping resulted in inferior pCR rates, particularly in the ER+ subgroup. To ensure optimal dosing, isotopic measurement of renal function is warranted in patients who would otherwise have their eGFR and dose capped.
An engineering approach to study the effect of saturation-dependent capillary diffusion on radial Buckley-Leverett flow
Authors: Meulenbroek Bernard , Gargar Negar Khoshnevis , Bruining Hans 
Published: August 2020

Abstract1D water oil displacement in porous media is usually described by the Buckley-Leverett equation or the Rapoport-Leas equation when capillary diffusion is included. The rectilinear geometry is not representative for near well oil displacement problems. It is therefore of interest to describe the radially symmetric Buckley-Leverett or Rapoport-Leas equation in cylindrical geometry (radial Buckley-Leverett problem). We can show that under appropriate conditions, one can apply a similarity transformation $(r,t) \rightarrow \eta = r^{2}/(2t) $
(
r
,
t
)
→
η
=

r

2

/
(
2
t
)
that reduces the PDE in radial geometry to an ODE, even when capillary diffusion is included (as opposed to the situation in the rectilinear geometry (Yortsos, Y.C. (Phys. Fluids 30(10),2928–2935 1987)). We consider two cases (1) where the capillary diffusion is independent of the saturation and (2) where the capillary diffusion is dependent on the saturation. It turns out that the solution with a constant capillary diffusion coefficient is fundamentally different from the solution with saturation-dependent capillary diffusion. Our analytical approach allows us to observe the following conspicuous difference in the behavior of the dispersed front, where we obtain a smoothly dispersed front in the constant diffusion case and a power-law behavior around the front for a saturation-dependent capillary diffusion. We compare the numerical solution of the initial value problem for the case of saturation-dependent capillary diffusion obtained with a finite element software package to a partially analytical solution of the problem in terms of the similarity variable η.
Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings
Authors: Mandoli Giulia Elena , Sciaccaluga Carlotta , Bandera Francesco , Cameli Paolo , Esposito Roberta , D’Andrea Antonello , Evola Vincenzo , Sorrentino Regina , Malagoli Alessandro , Sisti Nicolò , Nistor Dan , Santoro Ciro , Bargagli Elena , Mondillo Sergio , Galderisi Maurizio , Cameli Matteo ,   on behalf of Working group of Echocardiography of Italian Society of Cardiology (SIC)
Published: August 2020

AbstractCor pulmonale is the condition in which the right ventricle undergoes morphological and/or functional changes due to diseases that affect the lungs, the pulmonary circulation, or the breathing process. Depending on the speed of onset of the pathological condition and subsequent effects on the right ventricle, it is possible to distinguish the acute cor pulmonale from the chronic type of disease. Echocardiography plays a central role in the diagnostic and therapeutic work-up of these patients, because of its non-invasive nature and wide accessibility, providing its greatest usefulness in the acute setting. It also represents a valuable tool for tracking right ventricular function in patients with cor pulmonale, assessing its stability, deterioration, or improvement during follow-up. In fact, not only it provides parameters with prognostic value, but also it can be used to assess the efficacy of treatment. This review attempts to provide the current standards of an echocardiographic evaluation in both acute and chronic cor pulmonale, focusing also on the findings present in the most common pathologies causing this condition.
Strategic considerations for establishing a large-scale seaweed industry based on fish feed application: a Norwegian case study
Authors: Emblemsvåg Jan , Kvadsheim Nina Pereira , Halfdanarson Jon , Koesling Matthias , Nystrand Bjørn Tore , Sunde Jan , Rebours Céline 
Published: August 2020

AbstractSoy protein concentrate (SPC) is a key ingredient in fish feed and most of it originates from Brazil. However, the Brazilian soy industry has reportedly resulted in significant environmental problems including deforestation. Consequently, new sources for protein are investigated and protein extracted from farmed seaweed is considered an alternative. Therefore, we investigate how seaweed protein product (SPP) can compete against SPC as a protein ingredient for fish feed. The study uses the positioning matrix, cost analyses involving the power law, and uncertainty analysis using Monte Carlo simulations, and key research challenges are identified. The initial finding is that, with the emerging seaweed industry, the cost of producing SPP is too high to be competitive for fish feed applications. To overcome this challenge, two solutions are investigated. First, substantial investments in cultivation and processing infrastructure are needed to accomplish scale, and a break-even scale of 65,000 tonnes is suggested. The second but more promising avenue, preferably in combination with the former, is the extraction of seaweed protein and high-value seaweed components. With mannitol and laminaran as co-products to the SPP, there is a 25–30% probability of a positive bottom line. Researches on extraction processes are therefore a necessity to maximize the extraction of value-added ingredients. Over time, it is expected that the competitive position of SPP will improve due to the upscaling of the volume of production as well as better biorefinery processes.
Higher-Order Quantifier Elimination, Counter Simulations and Fault-Tolerant Systems
Authors: Ghilardi Silvio , Pagani Elena 
Published: August 2020

AbstractWe develop quantifier elimination procedures for fragments of higher order logic arising from the formalization of distributed systems (especially of fault-tolerant ones). Such procedures can be used in symbolic manipulations like the computation of pre/post images and of projections. We show in particular that our procedures are quite effective in producing counter abstractions that can be model-checked using standard SMT technology. In fact, very often in the current literature verification tasks for distributed systems are accomplished via counter abstractions. Such abstractions can sometimes be justified via simulations and bisimulations. In this work, we supply logical foundations to this practice, by our technique for second order quantifier elimination. We implemented our procedure for a simplified (but still expressive) subfragment and we showed that our method is able to successfully handle verification benchmarks from various sources with interesting performances.
Quantized Vortex Rings and Loop Solitons
Authors: Green P. J. , Grant M. J. , Nevin J. W. , Walmsley P. M. , Golov A. I. 
Published: August 2020

AbstractThe vortex filament model is used to investigate the interaction of a quantized vortex ring with a straight vortex line and also the interaction of two solitons traveling in opposite directions along a vortex. When a ring reconnects with a line, we find that a likely outcome is the formation of a loop soliton. When they collide, loop solitons reconnect as they overlap each other producing either one or two vortex rings. These simulations are relevant for experiments on quantum turbulence in the zero temperature limit where small vortex rings are expected to be numerous. It seems that loop solitons might also commonly occur on vortex lines as they act as transient states between the absorption of a vortex ring before another ring is emitted when the soliton is involved in a reconnection.
NM GRADS: Lessons Learned from Implementing a School-Based Program for Young Parents Across New Mexico
Authors: Harper Jessica , Hopper Dean , Keating Betsy , Harding Jessica 
Published: August 2020

Abstract
Purpose
The New Mexico Graduation Reality and Dual-role Skills (GRADS) program provides services for expectant and parenting students at high schools. The GRADS program has operated since 1989, serving more than 17,000 youth. This study summarizes the GRADS program model and program administrators’ lessons learned from implementing this comprehensive, large-scale program.

Description
The GRADS program is a multicomponent intervention that can include a classroom intervention, case management, linkages to child care and health care, and support for young fathers. The program aims to support expectant and parenting youth in finishing high school, delaying a repeat pregnancy, promoting health outcomes for their children, and preparing for college and career. This study presents program administrators’ lessons learned to increase understanding of how to implement a statewide program to support expectant and parenting students.

Assessment
During the 2010–2017 school years, the GRADS program operated in 26–31 sites each year, serving a total of 2691 parenting youth. Program administrators identified lessons learned from implementing the GRADS program during that period of expansion, including allowing variation across sites based on resources and needs, providing centralized implementation support, fostering buy-in from school and district leaders, and collecting consistent data to better understand participant outcomes.

Conclusions
Although not based on a rigorous impact or implementation study, this article provides lessons learned from a statewide, school-based program that may be a promising way to serve a large number of expectant and parenting youth and help them overcome challenges for completing high school.
On the application of the reachability distance in the suppression of mixed Gaussian and impulsive noise in color images
Authors: Smolka Bogdan , Kusnik Damian 
Published: August 2020

AbstractIn this paper, we address the problem of mixed Gaussian and impulsive noise reduction in color images. A robust filtering technique is proposed, which is utilizing a novel concept of pixels dissimilarity based on the reachability distance. The structure of the denoising method requires the estimation of the impulsiveness of each pixel in the processing block using the introduced local reachability concept. Furthermore, we determine the similarity of each pixel in the block to the central patch consisting of the processed pixel and its neighbors. Both measures are calculated as an average of modified reachability distances to the most similar pixels of the central patch and the final filtering output is a weighted average of all pixels belonging to the processing block. The proposed technique was compared with widely used filtering methods and the performed experiments proved its satisfying denoising properties. The introduced filtering design is insensitive to outliers and their clusters introduced by the impulsive noise process, preserves details and is able to efficiently suppress the Gaussian noise while enhancing the image edges. Additionally, we proposed a method which estimates the noise contamination intensity, so that the proposed filter is able to adaptively tune its parameters.
ICT skills measurement in social surveys: Can we trust self-reports?
Authors: Palczyńska Marta , Rynko Maja 
Published: August 2020

AbstractSelf-reports are the most common way of measuring information and communications technology (ICT) skills in social surveys. Studies comparing self-reported computer skills with objective assessments have found evidence of significant overreporting of skills, but were conducted only among non-representative groups of individuals. This paper fills an important gap by analysing the degree to which ICT skills are overreported in the working-age population of Poland, and the potential causes of this behaviour. We compare answers to Eurostat questions on ICT usage with direct assessments of the corresponding tasks. The results suggest that those individuals who are most likely to possess ICT skills are also most likely to overreport having these skills. The propensity to overreport decreases with age and increases with years of education and numeracy level; women are less likely than men to overestimate their skills. The positive relationship between the probability of a group to overreport their own skills and their expected levels of skills suggests that social desirability bias may explain this phenomenon.
Competition under revenue-cap regulation with efficiency benchmarking: tariff related incentives for gas transmission system operators in merged markets
Authors: Keller Jann T. , Kuper Gerard H. , Mulder Machiel 
Published: August 2020

AbstractIn Europe, gas market mergers aim at reducing restrictions on gas wholesale markets. Market mergers also allow network users to book transport capacity at different gas transmission system operators (TSOs), which may give rise to inter-TSO competition. Our theoretical analysis reveals the incentive for TSOs, operating under a revenue-cap regulation in merged markets, to charge lower tariffs at borders where different TSOs offer capacity, compared to borders where only one TSO offers capacity. This incentive does not directly result from revenue-cap regulation but is due to efficiency benchmarking. We test this hypothesis by applying a panel data analysis to tariffs charged at German border points between 2015 and 2018. In line with our hypothesis, we find lower tariffs at those border points where network users have a choice between different TSOs. An additional sensitivity analysis differentiating between transit and meshed networks confirms this result. We conclude that German TSOs, operating in merged markets and under a revenue-cap regime with efficiency benchmarking, compete for demand at borders at which different TSOs offer capacity.
ADHD symptoms, entrepreneurial passion, and entrepreneurial performance
Authors: Hatak Isabella , Chang Manling , Harms Rainer , Wiklund Johan 
Published: August 2020

AbstractRecent studies have substantially enhanced our understanding of attention deficit and hyperactivity disorder (ADHD) in entrepreneurship—articulating the theoretical relevance of ADHD-type traits in entrepreneurship and confirming the positive linkages between ADHD symptoms/diagnosis and entrepreneurial intentions and behavior. However, how and why some people with ADHD symptoms run successful ventures, while other entrepreneurs fail to perform well, is still not well established. Our study builds on a Gestalt perspective that integrates person–environment fit and broaden-and-build theorizing, and proposes that strong positive emotions enable entrepreneurs with ADHD symptoms (at the subclinical level) to mitigate/reinforce the effect of ADHD’s trait-specific weaknesses/strengths to achieve entrepreneurial performance. Relying on fuzzy-set methodology, our findings indicate that for entrepreneurs with ADHD symptoms, entrepreneurial performance occurs when they simultaneously experience passion for founding and developing. This passion configuration is unique to successful ADHD-type entrepreneurs. As such, this study offers novel theoretical and empirical insights as well as implications for practitioners.Plain English SummaryDo people with ADHD perform well in entrepreneurship? Our research shows how ADHD symptoms relate to entrepreneurial performance finding that passion is important. Entrepreneurs who are highly and thereby ambidextrously passionate for growing their businesses and for founding activities while lacking intense positive feelings for coming up with new ideas can benefit from ADHD. These results are important for people with ADHD and their loved ones.
Novel approach for electromyography-controlled prostheses based on facial action
Authors: Zhang Xiaodong , Li Rui , Li Hanzhe , Lu Zhufeng , Hu Yong , Alhassan Ahmad Bala 
Published: August 2020

AbstractIndividuals with severe tetraplegia frequently require to control their complex assistive devices using body movement with the remaining activity above the neck. Electromyography (EMG) signals from the contractions of facial muscles enable people to produce multiple command signals by conveying information about attempted movements. In this study, a novel EMG-controlled system based on facial actions was developed. The mechanism of different facial actions was processed using an EMG control model. Four asymmetric and symmetry actions were defined to control a two-degree-of-freedom (2-DOF) prosthesis. Both indoor and outdoor experiments were conducted to validate the feasibility of EMG-controlled prostheses based on facial action. The experimental results indicated that the new paradigm presented in this paper yields high performance and efficient control for prosthesis applications.
Progressive hedging for stochastic energy management systems
Authors: Kaisermayer Valentin , Muschick Daniel , Horn Martin , Gölles Markus 
Published: August 2020

AbstractEnergy systems have increased in complexity in the past years due to the ever-increasing integration of intermittent renewable energy sources such as solar thermal or wind power. Modern energy systems comprise different energy domains such as electrical power, heating and cooling which renders their control even more challenging. Employing supervisory controllers, so-called energy management systems (EMSs), can help to handle this complexity and to ensure the energy-efficient and cost-efficient operation of the energy system. One promising approach are optimization-based EMS, which can for example be modelled as stochastic mixed-integer linear programmes (SMILP). Depending on the problem size and control horizon, obtaining solutions for these in real-time is a difficult task. The progressive hedging (PH) algorithm is a practical way for splitting a large problem into smaller sub problems and solving them iteratively, thus possibly reducing the solving time considerably. The idea of the PH algorithm is to aggregate the solutions of subproblems, where artificial costs have been added. These added costs enforce that the aggregated solutions become non-anticipative and are updated in every iteration of the algorithm. The algorithm is relatively simple to implement in practice, re-using almost all of a possibly existing deterministic implementations and can be easily parallelized. Although it has no convergence guarantees in the mixed-integer linear case, it can nevertheless be used as a good heuristic for SMILPs. Recent theoretical results shown that for applying augmented Lagrangian functions in the context of mixed-integer programmes, any norm proofs to be a valid penalty function. This is not true for squared norms, like the squared $$L_2$$

L
2

-norm that is used in the classical progressive hedging algorithm. Building on these theoretical results, the use of the $$L_1$$

L
1

and $$L_{\infty }$$

L
∞

-norm in the PH algorithm is investigated in this paper. In order to incorporate these into the algorithm an adapted multiplier update step is proposed. Additionally a heuristic extension of the aggregation step and an adaptive penalty parameter update scheme from the literature is investigated. The advantages of the proposed modifications are demonstrated by means of illustrative examples, with the application to SMILP-based EMS in mind.
What does hand motor function tell us about our aging brain in association with WMH?
Authors: Riaz Misbah , Vangberg Torgil Riise , Vasylenko Olena , Castro-Chavira Susana , Gorecka Marta M. , Waterloo Knut , Rodríguez-Aranda Claudia 
Published: August 2020

AbstractBackgroundWhite matter hyperintensities (WMH) are a common cerebral finding in older people. WMH are usually asymptomatic, but excessive WMH are associated with cognitive decline and dementia. WMH are also among the neurological findings most consistently associated with declining motor performance in healthy ageing.AimsTo determine if WMH load is associated with simple and complex motor movements in dominant and non-dominant hands in cognitively intact older subjects.MethodsHand motor performance was assessed with the Purdue Pegboard and Finger-tapping tests on 44 healthy right-handed participants, mean age 70.9 years (range 59–84 years). Participants also underwent magnetic resonance (MR) imaging, which were used to quantify WMH volume. The effect of WMH on the motor parameters was assessed via mediation analyses.ResultsWMH load increased significantly with age, while the motor scores decreased significantly with age. WMH load mediated only the relationship between age and left-hand pegboard scores.DiscussionWMH mediated only the more complex Purdue Pegboard task for the non-dominant hand. This is likely because complex movements in the non-dominant hand recruit a larger cerebral network, which is more vulnerable to WMH.ConclusionsComplex hand movements in the non-dominant hand are mediated by WMH. Subtle loss of motor movements of non-dominant hand might predict future excessive white matter atrophy.
An Efficient Trap Passivator for Perovskite Solar Cells: Poly(propylene glycol) bis(2-aminopropyl ether)
Authors: Chen Ningli , Yi Xiaohui , Zhuang Jing , Wei Yuanzhi , Zhang Yanyan , Wang Fuyi , Cao Shaokui , Li Cheng , Wang Jizheng 
Published: August 2020

AbstractPerovskite solar cells (PSCs) are regarded as promising candidates for future renewable energy production. High-density defects in the perovskite films, however, lead to unsatisfactory device performances. Here, poly(propylene glycol) bis(2-aminopropyl ether) (PEA) additive is utilized to passivate the trap states in perovskite. The PEA molecules chemically interact with lead ions in perovskite, considerably passivate surface and bulk defects, which is in favor of charge transfer and extraction. Furthermore, the PEA additive can efficiently block moisture and oxygen to prolong the device lifetime. As a result, PEA-treated MAPbI3 (MA: CH3NH3) solar cells show increased power conversion efficiency (PCE) (from 17.18 to 18.87%) and good long-term stability. When PEA is introduced to (FAPbI3)1-x(MAPbBr3)x (FA: HC(NH2)2) solar cells, the PCE is enhanced from 19.66 to 21.60%. For both perovskites, their severe device hysteresis is efficiently relieved by PEA.