bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biofilm formation and extracellular microvesicles—The way of foodborne pathogens toward resistance
Authors: Begić Marija , Josić Djuro 
Published: September 2020

AbstractAlmost all known foodborne pathogens are able to form biofilms as one of the strategies for survival under harsh living conditions, to ward off the inhibition and the disinfection during food production, transport and storage, as well as during cleaning and sanitation of corresponding facilities. Biofilms are communities where microbial cells live under constant intracellular interaction and communication. Members of the biofilm community are embedded into extracellular matrix that contains polysaccharides, DNA, lipids, proteins, and small molecules that protect microorganisms and enable their intercellular communication under stress conditions. Membrane vesicles (MVs) are produced by both Gram positive and Gram negative bacteria. These lipid membrane‐enveloped nanoparticles play an important role in biofilm genesis and in communication between different biofilm members. Furthermore, MVs are involved in other important steps of bacterial life like cell wall modeling, cellular division, and intercellular communication. They also carry toxins and virulence factors, as well as nucleic acids and different metabolites, and play a key role in host infections. After entering host cells, MVs can start many pathologic processes and cause serious harm and cell death. Prevention and inhibition of both biofilm formation and shedding of MVs by foodborne pathogens has a very important role in food production, storage, and food safety in general. Better knowledge of biofilm formation and maintaining, as well as the role of microbial vesicles in this process and in the process of host cells’ infection is essential for food safety and prevention of both food spoilage and host infection.
Development and evaluation of an adapted physical activity program in anorexia nervosa inpatients: A pilot study
Authors: Kern Laurence , Morvan Yannick , Mattar Lama , Molina Estelle , Tailhardat Laura , Peguet Amandine , De Tournemire Renaud , Hirot France , Rizk Melissa , Godart Natalie , Fautrelle Lilian 
Published: September 2020

AbstractBackground and contextProblematic use of physical activity is frequent in subjects with anorexia nervosa (AN). Although it increases resistance to therapeutic treatment, paradoxically, physical activity in AN can also improve mental and physical health. Based on the literature review we hypothesized that adding an adapted physical activity (APA) program to treatment programs could be more beneficial than a total suppression of physical activities. We designed this open study to evaluate the outcome of AN inpatients after an APA program implementation as well as the perceived effect of APA.MethodForty‐one women with AN (17.2 (±2.5) years old, BMI of 16.86 (±2.0)) were included. An eight‐session (1 h30/session/week) standardized APA program was delivered and evaluated by structured questionnaires assessing exercise dependence, perceived physical activity, eating disorder (ED) symptoms, body mass index (BMI), along with an interview before and after the APA program.ResultsTwenty‐nine women complete the PA program and evaluation. BMI and perceived PA score significantly increased, ED and exercise dependence scores significantly decreased (p < .01). Participants appreciated the program.Discussion/conclusionThe inpatient program which included APA program helped AN inpatients in decreasing their ED symptoms and their dependence to PA, without any deleterious effect on BMI. Furthermore, APA was appreciated by participants.
Maillard conjugates and their potential in food and nutritional industries: A review
Authors: Liu Xiang , Xia Bing , Hu Long‐Teng , Ni Zhi‐Jing , Thakur Kiran , Wei Zhao‐Jun 
Published: September 2020

AbstractMaillard reaction (MR) is a cascade of complex interactions between reducing sugars and amine groups in food processing and storage. It produces a variety of volatile compound, nonenzymatic intermediates, and high molecular weight melanoidin contributing improved aroma, color, flavor, and antioxidant properties to the final food products. When uncontrolled, it can produce some harmful derivatives such as acrylamide, heterocyclic amine, advanced glycation end Products (AGEs), and other substances that can be detrimental to human health leading to cancer and chronic diseases. Herein, we reviewed the MR leading to different MRPs and factors affecting the MR and MRPs, their application in food model systems, their biological activities, and the formation mechanism and effective inhibition methods of common harmful MRPs. The updated overview can be useful to explore the rational use of MR, which can ameliorate its positive biological features with reduced adverse effects.
Curcumin (a constituent of turmeric): New treatment option against COVID‐19
Authors: Babaei Fatemeh , Nassiri‐Asl Marjan , Hosseinzadeh Hossein 
Published: September 2020

AbstractIn late December 2019, the outbreak of respiratory illness emerged in Wuhan, China, and spreads worldwide. World Health Organization (WHO) named this disease severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused by a new member of beta coronaviruses. Several medications are prescribed to patients, and some clinical trials are underway. Scientists are trying to find a specific drug against this virus. In this review, we summarize the pathogenesis, clinical features, and current treatments of coronavirus disease 2019 (COVID‐19). Then, we describe the possible therapeutic effects of curcumin and its molecular mechanism against coronavirus‐19. Curcumin, as an active constituent of Curcuma longa (turmeric), has been studied in several experimental and clinical trial studies. Curcumin has some useful clinical effects such as antiviral, antinociceptive, anti‐inflammatory, antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with COVID‐19. It has several molecular mechanisms including antioxidant, antiapoptotic, and antifibrotic properties with inhibitory effects on Toll‐like receptors, NF‐κB, inflammatory cytokines and chemokines, and bradykinin. Scientific evidence suggests that curcumin could have a potential role to treat COVID‐19. Thus, the use of curcumin in the clinical trial, as a new treatment option, should be considered.
Effect of pretreatment on physicochemical, microbiological, and aflatoxin quality of solar sliced dried ginger (Zingiber officinale Roscoe) rhizome
Authors: Amoah Roseline Esi , Wireko‐Manu Faustina Dufie , Oduro Ibok , Saalia Firibu Kwesi , Ellis William Otoo 
Published: September 2020

AbstractPretreatment of fruit and vegetables is necessary to reduce microbial proliferation and to preserve color of the produce. The effect of drying and pretreatment with potassium metabisulfite (KMBS) of concentrations 0.0%, 0.1%, 0.15%, 0.2%, and 1.0% and blanching at 100°C and 50°C using a tent‐like concrete solar (CSD) dryer as compared to open‐sun drying (OSD) of yellow ginger rhizomes was investigated using routine methods. The total color change and residual sulfur dioxide (SO2) were analyzed. KMBS reduced the yeast and mould load significantly from 3.6 × 104 ± 1.4 × 103 CFU/g in 0.0% (control) to <10 CFU/g in 1.0% KMBS and 100°C blanched fresh samples. Drying of the fresh samples for 5 days increased the yeast and mould load of all the treatments to as high as 1.15 × 105 ± 2.12 × 104 CFU/g for the 1.0% KMBS. Overall, the CSD had fewer microbial loads than the OSD but it was not significant. Aflatoxins and Salmonella sp. were not detected in any of the samples. The sulfur dioxide residue (SO2) for KMBS pretreated samples increased as the concentration of KMBS increased with the CSD retaining slightly higher amount than the OSD. The total color change index increased with increase in KMBS, and drying further increased the total color change index. On the whole, the blanched samples had the least color change among the pretreatments with 100°C CSD showing the least change among the dried samples.
Improvement in the Electrochemical Performance of Anode‐supported Solid Oxide Fuel Cells by Meso‐ and Nanoscale Structural Modifications
Authors: Seo H. , Kishimoto M. , Ding C. , Iwai H. , Saito M. , Yoshida H. 
Published: September 2020

AbstractTo improve the electrochemical performance of anode‐supported solid oxide fuel cells (SOFCs), microextrusion printing and wet infiltration techniques are employed for structural modification on the meso‐ (10–100 µm) and nanoscale order, respectively. In the mesoscale structural modification, anode ridge structures are fabricated by extruding an anode slurry on the surface of a flat anode disk to extend the electrode–electrolyte interfacial area. In the nanoscale structural modification, gadolinium‐doped ceria (GDC) nanoparticles are introduced into a porous lanthanum strontium cobalt ferrite (LSCF) cathode. To investigate the effects of mesoscale and nanoscale structural modifications, four different types of anode‐supported SOFC including a conventional cell are prepared, and their performance is evaluated at several operating temperatures. It is found that both the mesoscale and nanoscale structural modifications reduce not only the polarization resistance but also the ohmic resistance in the cells, resulting in the improvement in cell performance. Moreover, it is clarified that the improvement in cell performance becomes greater with decreasing operating temperature. Specifically, the maximum power density in the cell where both mesoscale and nanoscale structural modifications are applied is increased by 66% at 600 °C and 34% at 700 °C, compared with that in the conventional cell.
Characterization and sources of Paleolithic–Mesolithic ochre from Coves de Santa Maira (Valencian Region, Spain)
Authors: Aura Tortosa J. Emili , Gallello Gianni , Roldán Clodoaldo , Cavallo Giovanni , Pastor Agustín , Murcia‐Mascarós Sonia 
Published: September 2020

AbstractThe origin of iron‐oxide materials found at Paleolithic and Neolithic sites in the Spanish Mediterranean region is a pivotal issue that has not yet been explored. The aim of this study is to investigate the exploitation of local ochre sources during the different archaeological phases identified at the site of Coves de Santa Maira (Valencian Region, Eastern Spain). A sampling strategy and a methodological approach were developed. Lumps of ochre and raw materials were sampled from the archaeological site and its surroundings. The archaeological materials studied are from the occupational phases dated to between 15 and 6 ka cal BP, whereas the raw materials sampled from the surroundings of the cave are red fine‐grained and earthy‐grained sedimentary materials and Late Triassic (Keuper) clays. Morphological, mineralogical, and chemical analyses of the samples were carried out, and quantitative data on ochre fragments and processing tools recovered at the site were also included. Finally, Fe‐normalized and log10 transformed data and multivariate statistical analysis, using major, trace, and rare earth elements as variables, were applied to compare the mineralogical and chemical profiles of the archaeological materials with those from geological sources. The results obtained have provided interesting data about iron‐based mineral exploitation during Prehistory in the studied region.
CO2 to CO: Photo‐ and Electrocatalytic Conversion Based on Re(I) Bis‐Arene Frameworks: Synergisms Between Catalytic Subunits
Authors: Hernández‐Valdés Daniel , Fernández‐Terán Ricardo , Probst Benjamin , Spingler Bernhard , Alberto Roger 
Published: September 2020

AbstractReduction of CO2 to CO and H2O is a two electron/two proton process. For this process, multinuclear complexes offer advantages by concentrating reduction equivalents more efficiently than mononuclear systems. We present novel complexes with [Re(η6‐C6H6)2]+ as scaffold conjugated to one or two catalytically active [Ru(dmbpy)(CO)2Cl2] subunits (dmbpy=5,5′‐dimethyl‐2,2′‐bipyridine). The [Re(η6‐C6H6)2]+ scaffold was chosen due to its very high photo‐ and chemical stability, as well as the multiple degrees of freedom it offers for any conjugated functionalities. High efficiency and selectivity for the reduction of CO2 to CO (over H2 or HCOOH) is reported. TONs and TOFs were found to be comparable or higher than for the catalyst subunit without the rhenium framework. Cooperativity in photo‐ and electrocatalysis is observed for the complex comprising two catalytic subunits. The synergistic communication between the two catalytic subunits is responsible for the observed enhancement in both photo‐ and electrocatalytic performance. Confirmation of electronic communication between the two [Ru(dmbpy)(CO)2Cl2] subunits as well as the elucidation of a possible mechanism was supported by electrochemistry, IR‐spectroelectrochemistry and DFT studies.
Why nobody discusses the adverse psychiatric effects of chloroquine in case it might become the future treatment against COVID‐19?
Authors: Nessaibia Issam , Siciliano Dafne , Tahraoui Abdelkrim 
Published: September 2020

SummaryChloroquine represents at least a basic prototype antimalarial drug, widely applied in several branches of medicine and also recently against a new zoonotic origin coronavirus. At present, there is little awareness of chloroquine's psychiatric side effects, which appear to be overlooked by the Scientific Committee, although they may manifest in a worryingly wide range of symptoms. This is likely to interfere with the course of specifically long‐term (high‐dose) COVID‐19 treatment in some aggravated forms (25% of coronavirus patients were still carrying the virus 6 days after taking hydroxychloroquine). Besides, symptoms of infection, adverse effects from the 600 mg hydroxychloroquine daily plus azithromycin, including insomnia, headaches, skin reactions, digestive upset with nausea, vomiting, and diarrhea, blurred vision, and local pain, may lead to increased anxiety and mental distress.
Assessment of heat transfer and flow characteristics of a two‐phase closed thermosiphon
Authors: Ahmed Israa S. , Al Jubori Ayad M. 
Published: September 2020

AbstractIn this study, comprehensive modeling and simulations were developed and carried out to perform the investigation of the thermal performance of the enclosed thermosiphon through pool boiling in the evaporator sector and the condensation of the liquid film in the condenser part. To simulate these phenomena, the volume of fluid model was utilized. The simulation modeling using the computational fluid dynamics (CFD) technique was validated with existing experimental results, and a good agreement was reached. The simulation results were presented and evaluated in terms of temperature profiles and contours, the volume of fraction contours, and velocity vector distribution. Moreover, the thermal performance (ie, the heat transfer coefficient and thermal resistance) through the thermosiphon operation was analyzed. From the simulation results, it is found that the thermosiphon performance can be improved by the tilt angle and fill ratio. The results indicated that the optimal performance (ie, a high heat transfer coefficient and a low thermal resistance) was attained at a power input of 250 W, tilt angle of 90°, and fill ratio of 0.5. The established CFD simulations effectively predicted the formation of two‐phase flow pattern and boiling and condensation zones with water at a low power input, termed as geyser boiling.
Unconditional nonlinear stability for double‐diffusive convection with temperature‐ and pressure‐dependent viscosity
Authors: Mahajan Amit , Tripathi Vinit Kumar 
Published: September 2020

AbstractA linear and nonlinear stability analyses are carried out for a double‐diffusive chemically reactive fluid layer with viscosity being a function of temperature and pressure. The linear stability analysis is studied when the stabilizing salt gradient acts against the destabilizing thermal gradient. The effect of reaction parameters and variable viscosity on the stability of the system is studied for heated below, salted above, and the heated and salted below models with Rigid–Rigid boundary conditions. Chebyshev pseudospectral method is applied to determine the numerical solutions.
Effects ofPanax quinquefolius(American ginseng) on the steady state visually evoked potential during cognitive performance
Authors: White David J. , Camfield David A. , Ossoukhova Anastasia , Savage Karen , Le Cozannet Romain , Fança‐Berthon Pascale , Scholey Andrew 
Published: September 2020

AbstractObjectiveTo investigate the effects of acutePanax quinquefolius(American ginseng) administration on steady state visually evoked potentials (SSVEPs) during completion of working memory and continuous performance tasks.MethodsA randomised, double‐blind, placebo controlled, balanced, cross‐over trial was conducted in middle‐aged volunteers aged between 40 and 60 years. Participants were administered 200 mgP. quinquefoliusand placebo on two separate testing sessions. Six‐h post‐dose participants completed spatial working memory (SWM) and continuous performance (CP) tasks while SSVEP from a diffuse task‐irrelevant 13 Hz flicker was recorded.ResultsDuring SWM retrieval,P. quinquefoliuswas associated with significantly reduced prefrontal SSVEP latency. There were no significant treatment effects on CP nor behavioural performance of either task.ConclusionsThese findings provide preliminary evidence of increased recruitment of prefrontal brain regions during working memory processing following a single acute dose ofP. quinquefolius.
Climatic influences on forest fire and mountain pine beetle outbreaks and resulting runoff effects in large watersheds in British Columbia, Canada
Authors: Vore Margot E. , Déry Stephen J. , Hou Yiping , Wei Xiaohua 
Published: September 2020

AbstractMany studies have defined the interrelationships between climate, forest disturbance, and runoff at small scales (<100 km2), but few have translated these relationships to large watersheds (>500 km2). In this study, we explore the relationship between climate, extreme forest fire seasons, mountain pine beetle (MPB) outbreaks, and runoff in eight large watersheds within the Fraser and Peace drainage basins in British Columbia (BC), Canada from 1981–2019. Using a climate index based on precipitation and air temperature anomalies, we find extreme forest fire seasons (those that burned >5% of a watershed's area) are most likely to occur when a warm/dry summer is preceded by multiple seasons of cool/wet conditions. Using the climate suitability class (CSC) model to explore the relationship between climate and MPB outbreaks, we validate previous findings that lower‐than‐average precipitation, warm growing season temperatures, and lack of extremely cold temperatures during winter are connected to MPB outbreaks within central BC. However, the CSC model needs improvements to accurately assess MPB suitability in northern watersheds that are located outside the model's calibration region, either through weighted variables or lower degree day thresholds. Minimal runoff response occurs from these forest disturbances, with the most prominent runoff change being related to the 2014 fire season in the Osilinka and Mesilinka watersheds. The limited effects of forest disturbance on annual runoff are likely related to large watershed sizes, low percentages of disturbed area in some study watersheds and post‐MPB forest dynamics. These results provide valuable insight into the interrelationships of climate, forest disturbance and runoff in large Canadian boreal forested watersheds.
Passive money system and control of exchange rates: The case of Argentina 1976–1981
Authors: Futerman Alan G. 
Published: September 2020

AbstractThis paper analyses the consequences of controlling exchange rates, in the context of a passive money system. We use the administration of José Alfredo Martínez de Hoz at Argentina's Ministry of Economy in the period 1976–1981, during the last Argentine military dictatorship, as a case study. Following the work of Julio H. G. Olivera, the policies categorized under the passive money system are studied to corroborate the inconsistencies of the programme, in the context of the “trilemma” of open economies. In turn, a brief analysis of the administration in various areas is carried out, to identify its consequences. The paper finds that attempts to anchor inflation expectations in the context of a passive money system are not effective if large fiscal deficits need to be financed.
Flavonoid compound breviscapine suppresses human osteosarcoma Saos‐2 progression property and induces apoptosis by regulating mitochondria‐dependent pathway
Authors: Wang Zhijun , Li Hongyan , Yan Jiyuan , Liu Yang 
Published: September 2020

AbstractThis study was aimed to investigate the ability of a flavonoid compound breviscapine (BVP) to suppress growth and elicit apoptosis in human osteosarcoma (OS) Saos‐2 cells. The cells were cultured in vitro and treated with three concentrations of BVP (80, 160, and 320 μg/ml). Moreover, C57 mice were injected with Saos‐2 cells to establish a subcutaneous xenograft model, and they were subsequently treated with three doses of BVP via intraperitoneal injection. The viability of the cells was examined by the Cell Counting Kit‐8 method. The apoptotic cells were assessed by flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. The tumor volume and weight were monitored from day 3 through day 21 after the last injection. The expression of bax, bcl‐2, and cytochrome c (cyt c) mRNA was detected by a real‐time polymerase chain reaction. The protein levels of bax, bcl‐2, cyt c, caspase 3, and caspase 9 were evaluated by Western blot. The expression and distribution of bcl‐2 and bax in tissues were detected by immunohistochemistry. Compared with the control group, BVP treatment inhibited cell proliferation and induced apoptosis of Saos‐2 cells in vitro. Consistently, treatment of mice bearing transplanted tumors with BVP suppressed the growth of OS tumors and promoted cell apoptosis; it also reduced tumor volume and weight. Mechanistically, BVP‐induced apoptosis was mediated by the mitochondria‐dependent pathway, as evidenced by the increased expression of bax and cyt c and the decreased expression of bcl‐2, as well as activation of caspase 9 and caspase 3 in vitro and in vitro. Collectively, BVP inhibits growth and promotes apoptosis of OS by activating the mitochondrial apoptosis pathway.