bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Protein Phosphatase 1 Regulatory Subunit 3 as a Prognostic Biomarker in Patients with Gastric Cancer
Authors: Zhu Ya-Zhen , Liao Xi-Wen , Liu Yi , Mo Xian-Wei , Tang Wei-Zhong , Lin Yuan , Luo Shanshan 
Published: August 2020

Abstract
Background: The study aimed to determine: (1) The potential application of the protein phosphatase 1 regulatory subunit 3 (PPP1R3B) gene as a prognostic marker in gastric cancer (GC) and (2) The possible role of PPP1R3B in biological processes and pathways.Methods: The complete RNA-sequencing (RNA-seq) data and other relevant clinical and survival information was acquired from The Cancer Genome Atlas (TCGA). The univariate survival analysis with Cox regression model and Kaplan‐Meier analysis was used to investigate the association between clinical pathologic features and PPP1R3B gene expression. A genome-wide gene set enrichment analysis (GSEA) was also conducted to define the underlying molecular mechanism of the PPP1R3B gene in GC development.Results: The Log rank test and Cox regression identified the prognostic application of PPP1R3B expression in GC patients. Comprehensive survival analysis suggested that PPP1R3B might be an independent predictive factor for the survival time in patients with GC. The prognostic relationship between PPP1R3B and GC was also verified by the Kaplan–Meier plotter (KM plotter). Patients with a high expression of PPP1R3B were associated with a shorter clinical survival time. Additionally, GSEA demonstrated that PPP1R3B might be involved in multiple biological processes and pathways.Conclusions: Our findings demonstrated that the PPP1R3B gene could be used as a potential molecular marker for GC prognosis.
Effect of posterior cruciate ligament recession on knee joint pressure and joint space measured by an electronic pressure sensor during total knee arthroplasty
Authors: Zhao Ran , Liu Yanqing , Tian Hua 
Published: August 2020

Abstract
Purpose: The purpose of this study was to evaluate the change in posterior cruciate ligament (PCL) tension by directly measuring the pressure changes in the knee joint when the ligament was released or resected during total knee arthroplasty (TKA).Methods: We prospectively analysed 22 patients who underwent primary TKA (28 knees) between October 2019 and January 2020. The pressure changes in the medial and lateral compartment were measured with an electronic pressure sensor with PCL retention (at 0°, 45°, 90° and 120° of flexion), tibial recession and PCL resection, and changes in the knee joint space were measured.Results: At 0°, 45°, 90° and 120° of flexion, the total pressure in the knee joint after tibial recession of the PCL was significantly higher than with PCL resection, and higher than PCL recession, but only at 120°. Recession or resection of the PCL affected knee joint extension, and the medial/lateral pressure in the knee joint decreased. Pressure in the lateral compartment showed no significant change, while pressure in the medial compartment decreased significantly during knee flexion, which also led to a change in the ratios of the medial and lateral pressures in the knee joint. After resecting the PCL, the mean flexion and extension gaps increased by 0.64 mm and 0.46 mm, respectively.Conclusion: Tibial recession of the PCL can release the PCL while retaining some PCL function. PCL release affects both the flexion and extension gaps, and more cases will increase the flexion gap.
Effect and Safety of Naomaili Granules (脑脉利颗粒) for the Treatment of Acute Ischemic Stroke: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Authors: Li Xiaogang , Song Dongjing , Zhou Peiyang , Wang Huagang , Zhou Chengfang , Hu Bo , Li Wentao , Yang Dongdong 
Published: August 2020

Abstract
Background: It is of vital importance for the treatment and prognosis of Acute Stroke to find effective Chinese medicine that can be combined with western medicine in the acute stage. The purpose of this study is to investigate the effect and safety of Naomaili Granules (脑脉利颗粒, NML) for the treatment of acute stroke, hoping to provide a new idea and drug choice for the integrated treatment of Chinese and Western medicine in the acute stage of ischemic stroke, and at the same time to improve the treatment plan in the acute stage of ischemic stroke from the perspective of TCM syndromes. Methods: A total of 187 patients with acute ischemic stroke were randomly divided into the NML group (93 cases) and the placebo group (94 NML mimics), 1 bag (10g/bag), thrice daily for 20 days. Basic medications during the trial: Aspirin enteric-coated tablets, 1 tablet (0.1g/tablet), once a day. After treatment, the modified Rankin scale, the incidence of cardiovascular events and TCM Syndrome effect were the main efficacy indicators. Meanwhile, adverse events (AEs) were evaluated during the whole clinical trial. Results: In the FAS 90 days after the onset, the experimental group was 70.00%, and the control group was 45.24%. There was a statistically significant difference between the two groups. The incidence of acute cardio-cerebrovascular events was 1 case (1.08%) in the experimental group and 0 in the control group after 20 days of FAS treatment. Conclusion: The combined application of NML in the acute stage of ischemic stroke can effectively improve the prognosis of patients, and improve the independent survival ability of patients, and its safety is reliable, providing a new way of thinking and medication choice for the treatment of acute ischemic stroke with integrated traditional Chinese and western medicine.Trial registration: ChiCTR, ChiCTR2000033619. Registered 7 June 2020 - Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=54619
A Central Nervous System Focused Treatment Program for People with Frozen Shoulder: A Feasibility Study.
Authors: Horno Silvia Mena-del , Moscardó Lirios Dueñas , Lluch Enrique , Louw Adriaan , Luque-Suárez Alejandro , Navarro-Ledesma Santiago , Bernat Mercè Balasch i 
Published: August 2020

Abstract
Background: Frozen shoulder (FS) is a highly disabling pathology of poorly understood etiology, which is characterized by the presence of intense pain and progressive loss of range of motion (ROM). The aim of this study was to evaluate the feasibility and clinical impact of a CNS-focused treatment program for people with frozen shoulder (FS).Methods: 10 subjects with primary FS received a 10 weeks CNS-focused intervention including sensory discrimination training and graded motor imagery techniques delivered as clinic sessions (60 minutes) and home therapy (30 minutes five times per week). Measurements were taken at baseline, after a 2-weeks washout period, after treatment and at three months follow-up. The Shoulder Pain and Disability Index (SPADI) was the primary outcome. Secondary measures were: feasibility-related outcomes, self-reported shoulder pain, active and passive range of motion, two-point discrimination threshold (TPDT), left/right judgement task (LRJT), fear-avoidance (Tampa Scale for Kinesiophobia), pain catastrophization (Pain Catastrophizing Scale) and pain sensitization (Central Sensitization Inventory).Results: 70% of participants completed the treatment. No significant changes were found after washout period except for TPDT (p=0.02) and SPADI (p=0.025). Improvements in self-reported shoulder pain (p=0.028) and active shoulder flexion (p=0.016) were shown after treatment (p=0.028) and follow-up (p=0.001) and in SPADI at follow-up (p=0.008). No significant changes were observed in TPDT, LRJT, fear-avoidance, pain catastrophization and pain sensitization. Conclusions: a CNS-focused treatment program might be a suitable approach to improve pain and disability in FS but further research is needed to draw firm conclusions.Trial registration: Clinical Trials. NCT03320200. Registered 25 October 25 2017, https://clinicaltrials.gov/ct2/show/NCT03320200?term=NCT03320200&draw=2&rank=1
Spatial-temporal patterns and trends of homicide in socioeconomically deprived settings: violence surveillance in Alagoas, Brazil, 2006‒2015
Authors: Barbosa Kevan Guilherme Nóbrega , Walker Blake Byron , Silva Alessandra Vieira da , Gonzaga Géssyca Luise Procópio , Brum Evanisa Helena Maio de , Ribeiro Mara Cristina 
Published: August 2020

Abstract
Background

Homicide rates in the state of Alagoas (Brazil) have been high for a long time over the last decade. In this study, we quantified the violence rates and mapping the cities in higher risk for homicide.
Method:

A surveillance of homicide rates over ten years in the state of Alagoas, located in North-Eastern of Brazil was carried out through spatial-temporal analysis. First, the male/female ratio was calculated later the top violent cities and the relative risk for males and females were mapped.
Results

A total of 19,560 homicides were investigated in two large regions of the state called Metro Region and Inner Cities. A pattern of violence by homicide involving mostly men throughout all state was observed and highest rates for the metropolitan region of the state capital. Homicide has been spreading from the capital to other inner cities, and distinct pattern was observed when mapping the risk according to sex.
Conclusions

Homicide has remained as a serious local problem in the state over ten years, and our results suggest that inner areas in the state have experienced an increase of homicide rates, requiring strong investment in combat and prevention.
Effectiveness of personal letters to healthcare professionals in changing clinical practice behaviours: A Systematic Review protocol
Authors: Grimani Aikaterini , Goffe Louis , Tang Mei Yee , Beyer Fiona , Sniehotta Falko F. , Vlaev Ivo 
Published: August 2020

Abstract
Background: Letters are regularly sent by healthcare organisations to healthcare professionals to encourage them to take action, change practice or implement guidance. However, whether letters are an effective tool in delivering a change in clinical practice behaviour is currently uncertain. In addition, there are currently no evidence-based guidelines to support providers and health authorities with advice on how to formulate the communication, what information and behaviour change techniques to include in order to optimise the potential effect on the behaviour of the receivers. To address this research gap, we aim to inform such guidance through this systematic review.Methods/ Design: A systematic literature search of published and unpublished studies (the grey literature) in electronic databases will be conducted to identify studies that meet our inclusion criteria. The search will be conducted in five electronic databases: MEDLINE, EMBASE, PsycINFO, the Cochrane Library and CINAHL. We will also conduct supplementary searches in Google Scholar, hand search relevant journals, and conduct backward and forward citation searching for included studies and relevant reviews. A systematic approach to searching, screening, reviewing and data extraction will be applied based on Preferred Reporting Items for Systematic reviews and Meta-Analysis. Titles, abstracts, full-texts for eligibility will be examined independently by researchers. The quality of the included studies will be assessed using quality assessment tool for studies with diverse design and Cochrane risk of bias tool. Disagreements will be resolved by a consensus procedure.Discussion: This review aims to provide comprehensive evidence of the effectiveness of personal letters to healthcare professionals in changing clinical practice behaviours. Health policy makers across government will benefit from being able to increase compliance in clinical settings by applying theories of behaviour to design of policy communications. The synthesized findings will be disseminated through peer-reviewed publication.Systematic review registration: PROSPERO CRD42020167674
Syndromic Management of Female Sexually Transmitted Infections at Primary Care Level in Tunisia (Monastir 2007-2017)
Authors: Dhouib wafa , Zemni Imen , Kacem Meriem , Bennasrallah Cyrine , Fredj Manel Ben , Abroug Hela , Grira Samia , Mastouri Maha , Sr Asma Belguith 
Published: August 2020

Abstract
Background: In the world as in North Africa,Sexually Transmitted Infections (STIs) are a public health problem especiallyfor reproductive-age women.Since the quantification of the prevalence of STIs is important for the planning of interventions and the promotion of resources, it is necessary to have current data to evaluate the situation in the Maghreb and to give the answer as to the possibility of reaching the desired WHO goal of ending STIs epidemics as a public health concerns by 2030.The aim of this study was to determine the prevalence and trend of STIs during 11 yearsin Tunisia (2007-17).Methods: We conducted a descriptive cross-sectional study including all women with STIs diagnosed with the syndromic approach in all basic health care centers of the Governorate of Monastir (Tunisia) from 2007 to 2017.Syndromes included, Pelvic Pain (PP),Vaginal Discharge (VD)and Genital Ulceration (GU). Results: We analyzed 40388 cases of genital infection with a crude prevalence rate and age standardized prevalence rate of13.93/ 1000 inh and 72.38/ 1000 respectively.The prevalence rate was relatively high and showed a positive trend over 11 years for all age groups and syndromes. VD was the most common syndrome with a CPR of 11.7/1000. For all syndromes, women of childbearing age(20 to 39 years) were the most affected age group(p <0.05). Conclusion:Our results were consistent with the global evidence, suggesting a focus on primary prevention reinforcement and STIs surveillance system improving in North Africa countries to achieve the World health organization goalof ending STIs epidemics by 2030.
Performance of the lower limb musculoskeletal system in patients with different degree of diabetic ulcer risk
Authors: Bursać Snježana Novaković , Talić Goran , Tomić Nataša , Jandrić Slavica 
Published: August 2020

Abstract
BackgroundThe objective of the study was to determine the correlation between the biomechanical parameters: ankle and foot muscle strength, range of motion (ROM) at ankle joint (AJ), subtalar joint (SJ) and first metatarsophalangeal joint (I MTP) in patients with different diabetic ulcer risk assessed by IWGDF 2019 Guidance risk stratification system.MethodA cross-sectional study included 100 diabetic patients. The patients were classified into 4 risk categories of development of diabetic foot ulcer (DFU) applying IWGDF Guidelines 2019 stratification risk system. The function of ten foot and ankle muscles was evaluated by manual muscle testing and application of the Michigan Diabetic Neuropathy Score (MDNS) system. The range of motion ROM at the ankle, subtalar and first metatarsophalangeal joint was measured with a goniometer. The risk assessment was done applying IWGDF Guidelines 2019 stratification risk system. To test the statistical significance the ANOVA test was applied.ResultsAverage muscle strength in specified categories was category 0:9.2; category 1:13.9; category 2:13.3; category 3:15.2. Average ROM at AJ in specified categories was: category 0:49.3°; category 1:48.8°; category 2:45.5°; category 3:44.6°. Average ROM at SJ in specified categories was: category 0:37.8°; category 1:31.3°; category 2:35°; category 3:28.7°. Average ROM at I MTP in specified categories was: category 0:78.6°; category 1:74.4°; category 2:65.5°; category 3:57.9°. ConclusionThe risk for DFU significantly correlates with foot muscle strength and ROM at SJ, and I MTP, but does not with ROM at AJ.
Development and Evaluation of a New Assessment Tool for Myelopathy Hand
Authors: Su Xin-Jin , Lv Zhen-Dong , Zhang Wei-Zhong , Hou Cang-Long , Lao Li-Feng , Li Quan , Hong-Xing Shen 
Published: August 2020

Abstract
Background: Impairment of hand function in myelopathy patients is commonly observed. However, no objective and effective evaluation method has been widely accepted in clinical practice. The study aimed to evaluate the validity, reliability and effectiveness of a new assessment tool, Myelopathy-hand Functional Evaluation System (MFES), in evaluating the hand dysfunction of myelopathy-hand in the 10-s hand grip-and-release test (10s G-R test).Methods: MFES mainly consists of a pair of wise-gloves and a computer with software. All included patients received optimal surgery treatment. The Japanese Orthopedic Association (JOA) scores of each patient were marked and the hand function was evaluated using MFES before, and 6 months after surgery. All patients were asked to perform the 10s G-R test and the hand movements were simulated and converted into waveforms by MFES. The waveform parameters were measured and analyzed. The validity and test-retest reliability were assessed.Results: The Bland-Altman showed significant agreement with a low bias and narrow limits of agreement. The test-retest reliability was high with a significant value (r=0.911). The JOA scores and the number of G-R cycles significantly increased after surgery. Correspondingly, the waveforms of ulnar three fingers were significantly higher and narrower, along with the significantly declined average time per cycle in postoperative. The number of the first five-second segment (N1) was significantly higher than the second-five segment (N2) in postoperative, indicating the recovery of spinal cord function after surgery. The preoperative number of cycles was positively correlated with the improvement rates of JOA scores. And the increased number of cycles was significantly correlated with the improvement rates of JOA scores.Conclusion: MFES is a reliable and valid assessment tool for myelopathy hand, which can detect small changes of neurological function after decompression surgery.
The Differences of the Psychological Status of the Public Between Hubei Provinces and Other Provinces After the COVID-19 Outbreak: a Cross-sectional Study
Authors: Du Na , Ouyang Yingjie , Li Yunge , He Manxi , Geng Ting , Li Chunya , Hu Yalan , Liu Fengyu , Zhang Li , Zhu Min , Luo Lishi , Huang Juan , Wang Hongming , Chen Yong , Yue Yuchuan , Xiong Maoxiang , Pan Keliang 
Published: August 2020

Abstract
Background: Assessing the psychological status of public from different areas after the COVID-19 outbreak in China and analyzing the risk factors. Methods: A cross-sectional survey via online questionnaires was conducted. Occurrence of pressure, anxiety and depression were measured with Perceived Stress Scale (PSS), Generalized Anxiety Scale (GAD-7), and Patient Health Questionnaire-9 (PHQ-9), respectively. Results: The study included 3300 participants, with 1644 from Hubei and 1656 from outside Hubei. The rates of anxiety and depression among subjects from Hubei were 59.6% and 52.3%, while the corresponding rates for those outside Hubei were 44.4% and 46.6%. The scores of PSS, GAD-7, and PHQ-9 in Hubei were significantly higher than those in other areas (t = 3.823, 5.860, 2.211; P < 0.05). Multiple linear regression analysis indicated that among the participants from Hubei, the higher the educational background, the history of psychosis, the worse their physical health, the COVID-19 infected, isolated, and their families infected with the COVID-19, their mental health was relatively poor. In the participants outside Hubei, the more unstable their marriage status, the worse their physical health, isolated, and their families infected with the COVID-19, the worse their mental health level. Conclusions: The stress, anxiety, and depression of the public in Hubei are more prominent and the factors that affect their mental health are more complex. When conducting psychological intervention on the general public, we still need to formulate special intervention plans according to the different characteristics of different groups of people to provide them with appropriate crisis intervention services.
Investigating Teachers’ Self-efficacy, Instructional Practice and Self-reflective Practice: The Case of Tertiary Level Teachers
Authors: Khanshan Shabnam Kurosh , Yousefi Mohammad Hossein , Kashef Seyyed Hossein 
Published: August 2020

Abstract
The present study was an attempt to shed light on university level teachers’ self-efficacy perceptions in relation to their reflective practice and instructional practice. For this purpose, 70 teachers from both public and private universities in Iran took part in this survey research. Participants were asked to fill out three Likert-type questionnaires: Teacher Efficacy Scale, The Instructional Practices Survey, and Teacher Reflection Questionnaire. The collected data were quantitatively analyzed using SPSS version 21. Results of Pearson correlation coefficients revealed that although teachers’ self-efficacy perceptions were significantly correlated with both their instructional practice and reflective practice, the former established a relationship with a higher effect size than the latter. Implications of the results with respect to teacher development are presented and directions for further research are offered.
Atezolizumab and Granzyme B as Immunotoxin Against PD-L1 Antigen; An Insilico Study
Authors: Sefid Fateme , Payandeh Zahra , Baradaran Behzad , Nabbi Mohsen , Islami Maryam , Darvish Maryam , Kalantar Seyed Mehdi 
Published: August 2020

Abstract
Background

Programmed death-ligand 1 (PD-L1), also called B7 homolog 1 (B7-H1), is a human protein playing an important biomarker role in highly proliferation cells (like cancer cells) which is encoded by the CD274 gene. The interaction between PD-1 and PD-L1 inhibits T cell growth and cytokine secretion. Therefore, PD-L1 negatively regulates immune responses and permits tumor cells to evade immune surveillance. Thus, PD-L1 seems to be a suitable target for designing the immune-therapeutics.
Results

The predicted structure of this protein indicated that the chains were linked by (Gly4Ser)3 linker. In that line, using different simulation software, the structure of Granzyme B (GrB), a serine protease exists in cytotoxic lymphocytes granules as an apoptosis mediator, was attached to its specific antibody structure (Atezolizumab) via an adaptor sequence. Evaluation of accuracy, energy minimization and characterization of biological properties of the final processed structure were done. Our computational outcomes showed that the method of employed structure prediction has been successfully managed to design the immunotoxin structure.
Conclusion

It is necessary to mention that the precise and accurate design of the immune-therapeutic agents against cancer cells, can be confirmed by employed in-silico approach. So, using this method, we have designed a capable immunotoxin targeting the PD-L1 in an accurate orientation and cause the cancer cell destruction by its toxin domain.