bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary metabolite model to predict the dying process in lung cancer patients
Authors: Coyle Séamus , Chapman Elinor , Hughes David M. , Baker James , Slater Rachael , Davison Andrew S. , Norman Brendan P. , Roberts Ivayla , Nwosu Amara C. , Gallagher James A. , Ranganath Lakshminarayan R. , Boyd Mark T. , Mayland Catriona R. , Kell Douglas B. , Mason Stephen , Ellershaw John , Probert Chris 
Published: February 2025

Abstract

Background
Accurately recognizing that a person may be dying is central to improving their experience of care at the end-of-life. However, predicting dying is frequently inaccurate and often occurs only hours or a few days before death.

Methods
We performed urinary metabolomics analysis on patients with lung cancer to create a metabolite model to predict dying over the last 30 days of life.

Results
Here we show a model, using only 7 metabolites, has excellent accuracy in the Training cohort n = 112 (AUC = 0·85, 0·85, 0·88 and 0·86 on days 5, 10, 20 and 30) and Validation cohort n = 49 (AUC = 0·86, 0·83, 0·90, 0·86 on days 5, 10, 20 and 30). These results are more accurate than existing validated prognostic tools, and uniquely give accurate predictions over a range of time points in the last 30 days of life. Additionally, we present changes in 125 metabolites during the final four weeks of life, with the majority exhibiting statistically significant changes within the last week before death.

Conclusions
These metabolites identified offer insights into previously undocumented pathways involved in or affected by the dying process. They not only imply cancer’s influence on the body but also illustrate the dying process. Given the similar dying trajectory observed in individuals with cancer, our findings likely apply to other cancer types. Prognostic tests, based on the metabolites we identified, could aid clinicians in the early recognition of people who may be dying and thereby influence clinical practice and improve the care of dying patients.
Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas
Authors: Jokinen Vilja , Taira Aurora , Kolterud Åsa , Ahlgren Isa , Palin Kimmo , Katainen Riku , Räisänen Maritta , Kaasinen Eevi , Ilves Sini , Raitila Anniina , Kopp Kallner Helena , Siili Emma , Bützow Ralf , Heikinheimo Oskari , Pasanen Annukka , Karhu Auli , Välimäki Niko , Aaltonen Lauri A. 
Published: February 2025

Abstract

Background

Fibroblast growth factor 1-4 (FGFR1-4) are well-known oncogenic drivers in many cancer types. Here, we studied the role of FGFRs in uterine leiomyoma (UL) that is a benign neoplasm arising from the myometrium and the most common tumour in women. Although ULs can be classified to molecular subtypes based on genetic drivers, potential secondary drivers are not well characterised.

Methods
We performed mutation analysis of RNA-sequencing data of ULs, followed by screening of FGFR alterations in our Finnish (n = 2677) and Swedish (n = 372) UL collections, utilising Sanger-, next-generation and Nanopore sequencing and SNP array data. The role of FGFR genes in UL predisposition was examined by GWAS.

Results
We identified FGFR activation in a subset of ULs on both genetic and epigenetic levels. In addition to single-nucleotide mutations in FGFR1/2, we detected an FGFR2-ERC1 fusion gene, FGFR1 gains and hypomethylation of regulatory regions of FGFR2/3. FGFR alterations were enriched in molecularly similar HMGA2, HMGA1 and PLAG1 UL subtypes. We also unveil a UL predisposing variant upstream of FGFR4 associated with increased expression in both normal myometrium and ULs.

Conclusions
Our results establish the role of FGFR signalling in the genesis of UL.
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection
Authors: Rao Deepashri , Lewis Matthew , Meade-White Kimberly , Shaia Carl , Okumura Atsushi , Ferris Martin T. , Schäfer Alexandra , Baric Ralph , Feldmann Heinz , Hawman David W. 
Published: February 2025

Abstract
The Crimean-Congo hemorrhagic fever virus (CCHFV) causes Crimean-Congo hemorrhagic fever (CCHF), a widely distributed disease with significant morbidity and mortality. The virus has high genetic diversity correlated with geographic distribution but limited temporal evolution within regions. Despite this, cases of CCHF within a region present as a spectrum of disease from often unrecognized asymptomatic infections to severe, fatal viral hemorrhagic fever, suggesting host factors may play a role in disease outcome. We investigated the effect of host genetic diversity on the outcome of CCHFV infection in the genetically diverse Collaborative cross (CC)-mouse model. Infected mice recapitulated the full spectrum of disease recognized in humans, and similar to human disease, virus replication, tissue pathology, and inflammatory responses were associated with disease severity. Our study demonstrates that host genetics contribute to disease outcome in CCHF infection and establishes the CC mouse resource as a model to understand how host genetic diversity contributes to CCHF outcome.
Compact embedded RF sawtooth waveform generator for particle accelerator applications
Authors: Sharma Ashish , Kar Subrat , Sahu Bhuban Kumar 
Published: February 2025

A compact, wideband, completely reconfigurable, and digitally controlled embedded instrument has been designed to generate a sawtooth waveform in the radio frequency regime. This instrument drives an RF structure called a Multi-Harmonic Buncher in a particle accelerator. Its main application is to time-bunch a DC or continuous ion beam for nuclear physics experiments from a particle accelerator, such as an RF linear accelerator, to boost the beam energy. This paper elaborates on the construction of this instrument, including the design and implementation of multiple feedback controls and complex signal processing algorithms to generate a stable sawtooth waveform. The entire design is space and resource-optimized to be hosted on a single system-on-chip field programmable gate array board, which helped reduce the development effort. A TCP/IP-based server–client application has been developed and deployed on the instrument for easy remote operation and reconfiguration of various parameters. Many hardware complexities are handled by the firmware and control software, which provides additional design flexibility over the previous digital designs. While the system can be configured to generate a sawtooth waveform for any frequency in the range of 1–50 MHz, an example application of a 12.125 MHz sawtooth waveform has been presented in detail. This instrument will be tested with the Multi-Harmonic Buncher of the Pelletron and High-Current Injector accelerators of IUAC, New Delhi.
Rapid identification of shark species on mislabelled seafood products in Mexican markets
Authors: Jiménez-Pérez Alexis Alejandro , Garciglia-Mercado Carolina , Flores-Ramírez Sergio Francisco , Gónzalez-Armas Rogelio , Galván-Magaña Felipe , Zetina-Rejón Manuel Jesús , Cardona-Félix César Salvador 
Published: February 2025

Context Sharks have been captured globally for decades. Shark exploitation lacks appropriate regulation, hindering an assessment of captured and traded individuals. This necessitates the development of a method to quickly and easily identify shark species. Aims We aim to standardise and validate a rapid, effective method of shark species identification from Mexican markets. Methods Loop-Mediated Isothermal Amplification (LAMP) assays were developed for the identification of five commercially important shark species in the north-west region of Mexico: Carcharhinus falciformis, Prionace glauca, Isurus oxyrinchus, Sphyrna zygaena and Sphyrna lewini. A total of 350 samples was collected from markets and samples were labelled as ‘cazón’ (small shark), ‘marlín’ (marlin) and ‘tiburón’ (shark). Key results Through LAMP assay standardisation, individuals of five species were able to be identified: 17 individuals of S. zygaena, 17 of S. lewini, 24 of C. falciformis, 26 of P. glauca and 85 of I. oxyrinchus. To validate species identification by LAMP, sequences of COI and ITS2 were obtained and analysed by BLASTn. A 100% match identity for LAMP assays and associated sequences was obtained. Additionally, the DNA limit of detection was determined down to 0.1 ng/μL of shark DNA. Conclusions These results highlight an urgent need to effectively identify commercially traded species, some of which may be endangered and to establish species-level labelling in national policies. Implications Application of correct species labels to national seafood products could encourage consumers to make responsible food choices.
Narrating violent victimization by positioning self and others
Authors: Hatavara Mari , Presser Lois 
Published: February 2025

Abstract
Victimologists observe that telling one’s story can foster healing for survivors of violence. To understand these
processes better, victims’ narratives must be understood as situated acts of telling. This paper takes one man’s narration of
victimization long past — child abuse and rape — as a case. We examined his interview-derived storytelling with a focus on
narrative positioning, narrative discourse modes, and negations. We found that Stefan (a pseudonym) used various discursive modes
and narrative positionings to exercise control over the stories and what they mean. His agency was partly achieved by what he
recounted not doing or saying, and what he refused to address in the interview situation. Thus, his narratives feature his own
defiance and self-empowerment in both the scene and the aftermath of violence. These findings lead us to conclude that narrative
strategies of storytelling should be taken into account in any practical interventions that involves testimony about harm.
Attenuation characteristic of stress-wave in load-bearing soft-rock under different impact loading
Authors: Zhi Bin , Gao Yongji , Sun Yinhao , Qu Yakang 
Published: February 2025

Abstract
To explore the wave development law affected by impact loading, taking the sandstone of a tunnel as the material, this paper analyzed its development characteristics. The results show that stress significantly affects the propagation of stress waves. The peak of the compressive wave gradually decreases, and its waveform remains similar throughout. The stress influences the frequency spectrum characteristic. The frequency spectrum value initially shows a stage response law. Under the same load environment, the main frequency has a significant peak, and there is no secondary main frequency. In the low-stress environment, the main-frequency attenuation rate has high dispersion, and the data generally decreases nonlinearly. With the increase of the load value, the attenuation rate slows down, showing a typical linear development trend. The findings are of great significance for exploring the deterioration mechanism of sedimentary rock.
Natural convection characteristics of closed cavity in airflow inclination sensor
Authors: Zheng Yonghong , Xiao Wei 
Published: February 2025

Abstract
The basic equations of natural convection in a closed cavity are introduced and the characteristic numbers of natural convection are calculated. The results show that the convective problem of the cavity belongs to the small Reynolds number problem. The viscous force plays a major role. The thickness of the temperature boundary layer and the flow boundary layer in the closed cavity is approximately equal. The method of improving the stability of the sensor is proposed by the discussion of the Grashof number. The convective heat transfer in a closed cavity is equivalent to the thermal transfer of the cavity.
Dynamic response of panel dam of Anti-seepage reservoir basin considering Dam-reservoir water hydrodynamic interaction
Authors: Meng Yayun , Ye Xiangfei , Liu Yaolai , Wang Xiafei , Qiu Yun , Yuan Li , Liu Man 
Published: February 2025

Abstract
Based on the fluid motion equation, the finite element equation of the dam-reservoir water coupling system was established to calculate the dynamic response between the compressible reservoir water and the face rockfill dam, the dynamic response was compared with the dynamic response calculated by the Westergaard added mass formula, and the compressible and incompressible calculation results of the reservoir water were discussed. The results show that the failure of the panel tensile stress to exceed the standard will affect the overall anti-seepage safety of the reservoir basin. Although the dynamic response calculated by the Westergaard formula has little effect on the absolute acceleration and maximum dynamic displacement, it underestimates the influence of hydrodynamic pressure, and the calculated static and dynamic superimposed tensile stress along the slope is smaller. Therefore, it is necessary to consider the dam-reservoir water hydrodynamic interaction when the face rockfill dam of the anti-seepage reservoir basin is subjected to seismic analysis. In addition, the hydrodynamic pressure distribution when the water body is compressible is similar to when the water body is incompressible and only increases in numbers.
The lifespan of solutions for damped semilinear hyperbolic equation with logarithmic nonlinearity
Authors: Zu Ge , Lv Bo 
Published: February 2025

Abstract
This paper deals with the hyperbolic equation with strong damping, weak damping, and logarithmic nonlinearity. We prove a finite time blow-up result for high initial energy and the upper bounds of the blow-up time are obtained by using improved Levine’s concavity method. Furthermore, a control function with a small dissipative term is defined to obtain lower bounds of the blow-up time.
Lower bound for the minimal eigenvalue of M-matrices
Authors: Zhong Qin 
Published: February 2025

Abstract

M-matrices have several applications in domains such as control theory, numerical analysis, optimization problems, probability, and statistics. One of the key areas of M-matrix theory is the study of minimal eigenvalues of M-matrices. The goal of this note is to introduce a better lower bound for the minimal eigenvalue of M-matrices using the special inclusion theorem for matrix eigenvalues. Two numerical tests are considered to confirm the efficiency of the new lower bound.
A property of irrational numbers and its application in music
Authors: Chen Genfang 
Published: February 2025

Abstract
The concept of irrational envelope numbers and some properties of their polynomial range were introduced in this paper. The paper proves the number of two intervals forming a unit circle of Circumference 1, proposes a method of rolling subtraction to find the number of musical tones needed for any small comma in music, and finally gives the cent value of the interval corresponding to some envelope numbers.
Study on the joint detection of coalfield ‘skylight’ structure by high-density resistivity method and transient electromagnetic method
Authors: Tong Jingyang , He Xiaolong , Dong Yi 
Published: February 2025

Abstract
The water-conducting channel formed between adjacent aquifers is called ‘skylight’, which is an important factor leading to water and water-sand inrush accidents in coal mines. In order to find out the possible spatial position of the ‘skylight’ structure in a coal mine, the opposing coil’s transient electromagnetic method(OCTEM) and the high-density resistivity method are utilized for joint detection. Combined with geological data to interpret the resistivity section of the transient electromagnetic method, the position of low resistance anomaly is delineated. The results of the data are processed by 3D visualization. The results of the data are a ‘funnel-shaped’ structure in 3D space. Meanwhile, The findings in the high-density resistivity method further indicate that the resistivity at the delineated anomalous location exhibits a notable decrease compared to the resistivity of the adjacent rock formations.The results of the two methods verify each other and confirm the development position of the ‘skylight’ structure. The research shows that the combined detection of the transient electromagnetic method and high-density resistivity method can better identify the ‘skylight’ structure of coalfield, and can provide a safe geological guarantee for coal mine production, which has good application value and promotion significance.
Enhanced energy absorption in star-shaped honeycomb structures through the negative poisson’s ratio effect
Authors: Ren Jianpeng , Gu Zhoupeng , Zhao Aiguo , Wu Xianqian 
Published: February 2025

Abstract
Star-shaped honeycomb (SSH) structures exhibit broad application potential in impact protection by the negative Poisson’s ratio (NPR). However, existing research has primarily focused on conventional structures with positive Poisson’s ratios (PPR), leaving the performance of NPR effects in SSH, particularly in combination with other materials, insufficiently explored. This study aims to investigate the NPR effect in SSH structures by systematically analysing the influence of varying Poisson’s ratios on energy absorption performance through wall angle adjustments. Results indicate that the NPR effect significantly enhances the specific energy absorption of SSH. Furthermore, in the coupling system of SSH filled with shear-thickening fluid, the NPR effect further augments energy absorption and establishes a stable energy dissipation mechanism under dynamic impact conditions. This study provides theoretical and experimental support for the application of SSH structures in impact protection and introduces an effective strategy for designing energy-absorbing structures through SSH-STF coupling.
Thermal environment modelling - assessment of Fanger model’s usability in the smart building supplied from renewable energy sources
Authors: Dębska Luiza , Siwczuk Natalia 
Published: February 2025

Abstract
The proper design of smart buildings, usually powered with renewable energy sources, should ensure that the indoor conditions are comfortable and users experience thermal comfort throughout the year. The existing model of thermal comfort comes from the 60’s/70’s and was the basis for the ISO 7730 Standard. It utilizes the concept of the PMV (Predicted Mean Vote) and PPD (Predicted Percentage Dissatisfied) indicators. The current paper compares the actual expressions of people (as indicated by them in the anonymous questionnaires) with the PMV/PPD values calculated according to the Standard. Therefore, 76 people aged 20 to 40 were examined during the heating period. The temperature in the rooms ranged from 21.6°C to 24.1°C, and the insulation of the clothes of the examined people ranged from 0.40 to 1.39 clo. Differences between these values have been discussed and conclusions have been drawn as to the usability of this thermal comfort model in smart buildings, which still seem to be a novelty in Central European countries and data on their thermal comfort performance is still quite modest.
Lithium-ion-battery state of health estimation based on coefficient of variation
Authors: Liao Zihan , Zhang Zijie , Yang Jin , Li Chaoyang , Li JinJing , Han Jingang 
Published: February 2025

Abstract
The state of health (SOH) is an important indicator of the reliable and safe working of lithium-ion battery systems in new energy vehicles and energy storage power stations. In order to find a fast, accurate, concise and understandable approach for estimating the SOH of lithium-ion batteries, a health estimation method for lithium-ion batteries is proposed based on the coefficient of variation (COV) as the health factor. The battery SOH is estimated by deriving the COV based on the charge and discharge voltage series of li-ion batteries over a certain voltage window or a certain state of charge (SOC) range, calculating its linear relationship with the SOH, and finally building a COV-SOH model. The effects of different voltage windows on the health estimation model of nickel-cobalt-aluminum ternary batteries (NCA) and ferrous lithium phosphate (LFP) batteries are also investigated at different multiplications of the charging and discharging process. The results illustrate that for NCA batteries, the COV is linearly positively correlated with SOH for both voltage series based on 0.25C, 0.5C, and 1C charging multiplicity as well as 1C discharging, with a coefficient of determination (R2) of up to 0.98 after linear fitting; for the LFP batteries, the COV is linearly negatively correlated with SOH, whether based on partial voltage sequences of 5.2C and 4.2C charging or 4C discharging, with a R2 of up to 0.99 after linear fitting. The COV-SOH model demonstrates a strong linear correlation for both NCA and LFP batteries, under both charging and discharging conditions, and across a range of current multiplication rates, indicating the model’s high robustness.
Evaluation of Performance of Thermoelectric Generator Using Ethylene Glycol as a Heat Exchanger
Authors: Tan Nguyen Tien , Dien Vu Minh , Binh Pham Hoa , Quang Khong Vu , Vinh Nguyen Duy 
Published: February 2025

Abstract
This research examines the impact of heat exchanger solvents on the power-generating performance of a thermoelectric generator (TEG). The experimental configuration includes TEG modules and a heat exchange system utilizing water and ethylene glycol as solvents for comparative analysis. The temperature and mass flow of the heat exchanger solution were modified to assess the performance parameters. According to ly, the power of the TEG using ethylene glycol is smaller than that using water due to the difference in the heat exchange coefficient. Indeed, the freshwater heat capacity is 4.19 kJ/(kg oC), while the heat capacity of ethylene glycol is only 2.36 kJ/(kg oC). The findings indicated that the performance of the TEG is contingent upon the kinds of heat exchanger solvents and the intake temperature. The proposed experimental configuration is applicable for assessing thermoelectric energy potential or examining optimal cooling or heating procedures.
Modeling of hydrogen-enriched natural gas on flame speed propagation
Authors: Zvada Branislav , Nosek Radovan , Patsch Marek , Pilát Peter , Backa Alexander 
Published: February 2025

Abstract
This study investigates the effects of hydrogen addition on the laminar flame speed of natural gas using computational simulations performed with Cantera. The calculated laminar flame speed of hydrogen-enriched natural gas mixtures was simulated across a range of equivalence ratios (0.6-2) and hydrogen fractions (0-25% by volume). The modified GRI-Mech 3.0 mechanism was employed. Results demonstrate a significant increase in laminar flame speed with increasing hydrogen content, with the effect more pronounced at higher equivalence ratios. The peak flame speed was observed in stoichiometric conditions with increasing hydrogen fraction. The highest speed is achieved with a 25% hydrogen concentration in a natural gas mixture, reaching 45.219 cm/s at an equivalence ratio of 0.9. This study provides insights into the combustion characteristics of hydrogen-enriched natural gas and demonstrates the utility of Cantera for such simulations.