bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new goodness of fit test in the presence of uncertain parameters
Authors: Aslam Muhammad 
Published: October 2020

AbstractThe Weibull distribution has been widely used in the areas of quality and reliability. The Anderson–Darling test has been popularly used either the data in hand follow the Weibull distribution or not. The existing Anderson–Darling test under classical statistics is applied when all the observations in quality and reliability work are determined, précised, and exact. In the areas of reliability and quality, the data may indeterminate, in-interval and fuzzy. In this case, the existing Anderson–Darling test cannot be applied for testing the assumption of the Weibull distribution. In this paper, we present the Anderson–Darling test under neutrosophic statistics. We present the methodology to fit the neutrosophic Weibull distribution on the data. We discuss the testing procedure with the help of reliability data. We present the comparisons of the proposed test with the existing Anderson–Darling the goodness of fit test under classical statistics. From the comparison, it is concluded that the proposed test is more informative than the existing Anderson–Darling test under an indeterminate environment. In addition, the proposed test gives information about the measure of indeterminacy.
A Simple Thermal Conductivity Model for Unsaturated Geomaterials Accounting for Degree of Saturation and Dry Density
Authors: Bruno Agostino Walter , Alamoudi Doaa 
Published: October 2020

AbstractThis paper proposes a simple thermal conductivity model for geomaterials accounting for the combined effect of both degrees of saturation and dry density. The model only requires the determination of the thermal conductivity under dry conditions (i.e., at a degree of saturation equal to zero) and as little as two additional measurements of thermal conductivity performed at different levels of degree of saturation and dry density. The model is a function of only two fitting parameters, namely the moisture factor $${m}_{f}$$

m
f

and the density factor $${m}_{d}$$

m
d

. Despite its simplicity, the model can correctly predict the thermal conductivity of geomaterials and this has been validated against five sets of experimental data obtained on a very broad range of materials ranging from fine (e.g., bentonite) to coarser soils (e.g., a mix of gravel, coarse sand and silt) tested at different levels of degree of saturation and dry density. The paper also shows that the model can be applied to different engineering contexts such as (a) the thermal behaviour of earth materials used for building construction, (b) the thermal performance of bentonites employed for the storage of nuclear waste and (c) the estimation of the heat exchange in shallow geothermal reservoirs. Finally, the proposed model can be easily implemented in a finite element code to perform numerical simulations to study the heat transfer in unsaturated geomaterials.
Systematic Side-Channel Analysis of Curve25519 with Machine Learning
Authors: Weissbart Léo , Chmielewski Łukasz , Picek Stjepan , Batina Lejla 
Published: October 2020

AbstractProfiling attacks, especially those based on machine learning, proved to be very successful techniques in recent years when considering the side-channel analysis of symmetric-key crypto implementations. At the same time, the results for implementations of asymmetric-key cryptosystems are very sparse. This paper considers several machine learning techniques to mount side-channel attacks on two implementations of scalar multiplication on the elliptic curve Curve25519. The first implementation follows the baseline implementation with complete formulae as used for EdDSA in WolfSSl, where we exploit power consumption as a side-channel. The second implementation features several countermeasures, and in this case, we analyze electromagnetic emanations to find side-channel leakage. Most techniques considered in this work result in potent attacks, and especially the method of choice appears to be convolutional neural networks (CNNs), which can break the first implementation with only a single measurement in the attack phase. The same convolutional neural network demonstrated excellent performance for attacking AES cipher implementations. Our results show that some common grounds can be established when using deep learning for profiling attacks on very different cryptographic algorithms and their corresponding implementations.
Baton Rouge (Louisiana): On the Importance of Thematic Cartography for 'Neopragmatic Horizontal Geography’
Authors: Kühne Olaf , Jenal Corinna 
Published: October 2020

AbstractThe presented contribution is based on the testing of a 'neopragmatic' access to spaces in the context of horizontal geography using the case study of Baton Rouge, Louisiana (USA). In this approach, the focus is less on the theoretical framing or the detailed development of community development, but rather on the importance of thematic cartography in the neopragmatic approach of regional geography. The neopragmatic approach prioritizes the multi-perspective study of spatial constellations over theoretical 'purity' and methodological clarity. The investigation is 'horizontally' oriented and is characterized by the constructivist framed synthesis of research results from different disciplines (e.g., on economic or structural development).
Genital Gender-Affirming Surgery Without Urethral Lengthening in Transgender Men—A Clinical Follow-Up Study on the Surgical and Urological Outcomes and Patient Satisfaction
Authors: Pigot Garry L.S. , Al-Tamimi Muhammed , Nieuwenhuijzen Jakko A. , van der Sluis Wouter B. , Moorselaar R.Jeroen A. van , Mullender Margriet G. , van de Grift Tim C. , Bouman Mark-Bram 
Published: October 2020

Abstract

Background
Genital gender-affirming surgery (gGAS) with urethral lengthening (UL) in transgender men is associated with high urological complication and reoperation rates. Since 2009, we offer gGAS without UL to avoid these complications.

Aim
The aim of this study was to assess what portion of the transgender men opted for gGAS without UL and to assess functional, surgical outcomes, and patient satisfaction after gGAS without UL.

Material and methods
Retrospective data were collected from patients’ charts. The International Prostate Symptom Score, uroflowmetry, and 24-hour frequency voiding chart were used to assess voiding, and a self-constructed semistructured questionnaire was used to assess patient-reported outcomes. Transgender men who underwent gGAS without UL between January 2009 and January 2018 were included, and 56 transgender men were approached to complete the patient-reported outcome measurement. The simple statistical analysis combined with the Mann-Whitney U test and the Wilcoxon signed-rank test was used.

Outcomes
68 transgender men were included. Median follow-up time was 24 (6–129) months. Uroflowmetry and the International Prostate Symptom Score were completed by 44 transgender men, whereas 13 completed the frequency voiding chart preoperatively and postoperatively, respectively. The patient-reported outcome measurement was completed by 40 of 56 (71%) transgender men.

Result
Postoperative surgical and urological complications occurred in 9 of 68 (13%) and 8 of 68 (12%) patients, respectively. Storage and voiding function remained unchanged. The median quality of life because of urinary symptoms was scored as “pleased.” Sexual functioning and voiding were scored satisfactory and very satisfactory in 18 of 40 (45%) and 21 of 40 (53%) patients, respectively. The number of patients satisfied with the penis and neoscrotum was 25 of 40 (63%) and 26 of 40 (65%), respectively. Increased self-esteem was reported by 32 of 40 (80%), 32 of 40 (80%) would undergo the surgery again, and 28 of 40 (70%) would recommend it to others.

Clinical Implications
gGAS without UL should be part of the surgical armamentarium in centers performing gender-affirming surgery.

Strengths and limitations
Strengths of this study comprise the number of patients, the completeness of data, incorporation of patient-reported outcomes, and description of a relatively new surgical approach that may be well-suitable for a subgroup of transgender men. Limitations are the retrospective study design and the lack of validated questionnaires.

Conclusion
gGAS without UL shows good surgical and urological outcomes. After extensive counseling, the majority of this selective group of patients shows favorable patient-reported outcomes.
In-Hospital Endocrinology Consultation After Transsphenoidal Surgery: Is It Always Necessary?
Authors: Clarke David B. , Hebb Andrea L.O. , Massoud Emad , Imran Syed Ali 
Published: October 2020

ABSTRACT:Background:Patients with sellar masses undergoing transsphenoidal surgery (TSS) frequently develop endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended. However, we wondered whether routine endocrinology assessment of all TSS patients is always necessary.Methods:We developed an IHEC Physician’s Guide to identify patients who would require peri-operative IHEC. An analysis of all patients undergoing TSS for a sellar mass over a 4-year period was conducted to assess the predictive value of the IHEC Physician’s Guide in identifying patients who required IHEC.Results:A total of 116 patients underwent TSS; 24 required IHEC. As expected, the risk of endocrine complications requiring peri-operative endocrine management was significantly higher in the IHEC group versus no-IHEC group (96% vs. 1%; p < 0.001). The negative predictive value of the IHEC Physician’s Guide in identifying patients who did not require IHEC was 0.99 (95% CI 0.9409–0.9997); Fisher’s exact test, p < 0.001), meaning that the IHEC Physician’s Guide successfully identified all but one patient who truly required IHEC.Conclusion:Results from our study show that most patients do not need IHEC after TSS and that those patients requiring IHEC can be reliably predicted at surgery by using a simple IHEC Physician’s Guide.
Value of mesenchymal stem cell therapy for patients with septic shock: an early health economic evaluation
Authors: Thavorn Kednapa , van Katwyk Sasha , Krahn Murray , Mei Shirley H.J. , Stewart Duncan J. , Fergusson Dean , Coyle Doug , McIntyre Lauralyn 
Published: October 2020

Background.This study estimates the maximum price at which mesenchymal stem cell (MSC) therapy is deemed cost-effective for septic shock patients and identifies parameters that are most important in making treatment decisions.MethodsWe developed a probabilistic Markov model according to the sepsis care trajectory to simulate costs and quality-adjusted life years (QALYs) of septic shock patients receiving either MSC therapy or usual care over their lifetime. We calculated the therapeutic headroom by multiplying the gains attributable to MSCs with willingness-to-pay (WTP) threshold and derived the maximum reimbursable price (MRP) from the expected net monetary benefit and savings attributable to MSCs. We performed scenario analyses to assess the impact of changes to assumptions on the study findings. A value of information analysis is performed to identify parameters with greatest impact on the uncertainty around the cost-effectiveness of MSC therapy.ResultsAt a WTP threshold of $50,000 per QALY, the therapeutic headroom and MRP of MSC therapy were $20,941 and $16,748, respectively; these estimates increased with the larger WTP values and the greater impact of MSCs on in-hospital mortality and hospital discharge rates. The parameters with greatest information value were MSC's impact on in-hospital mortality and the baseline septic shock in-hospital mortality.ConclusionAt a common WTP of $50,000/QALY, MSC therapy is deemed to be economically attractive if its unit cost does not exceed $16,748. This ceiling price can be increased to $101,450 if the therapy significantly reduces both in-hospital mortality and increases hospital discharge rates.
Practitioner Empowerment, Older Adult Mistreatment, and Dementia
Authors: Lindenbach Jeannette , Larocque Sylvie , Morgan Debra , Jacklin Kristen 
Published: October 2020

ABSTRACTAlthough some studies have revealed practitioner disempowerment in cases of older adult mistreatment, this experience is poorly understood. In addition, dementia and contextual influences further complicate cases; yet, little is known about the experience of practitioners with this complexity. This critical inquiry, based on Critical social theory, critical consciousness, and professional agency, aimed to address these gaps. Fifty-one practitioners from diverse health care and social service disciplines from rural and urban communities in Northeastern Ontario participated in interviews, journals, and focus groups. Analysis of data revealed the need for empowerment within a perpetual cycle of non-resolution, to refocus on legal clarity and intervention versus the current legal complexity and education focus, and to develop adequate infrastructure to support interprofessional efforts. The infusion of this knowledge into policy, practice, and research has great potential to improve outcomes for older adults with dementia who are mistreated in their homes.
Possession is Nine-Tenths of the Law: possession, property, and coordination in a Hawk–Dove Experiment
Authors: Fabbri Marco , Rizzolli Matteo , Maruotti Antonello 
Published: October 2020

AbstractIn all legal systems, possession and property are inextricably linked. Game theory captures this relationship in the Hawk–Dove game: players competing for an asset are better off when the possessor plays Hawk and the intruder plays Dove (the bourgeois strategy) so that property can emerge as a spontaneous convention. This theory has been supported by large experimental evidence with animals. This paper presents a lab experiment where possession is manipulated to study the emergence of the property convention with human subjects. We show that the highest coordination emerges when possession is achieved meritoriously and that possession induces only bourgeois coordination (never antibourgeois).
The Power to Detect Cultural Transmission in the Nuclear Twin Family Design With and Without Polygenic Risk Scores and in the Transmitted–Nontransmitted (Alleles) Design
Authors: Bruins Susanne , Dolan Conor V. , Boomsma Dorret I. 
Published: October 2020

AbstractWe compare the power of two different approaches to detect passive genotype–environment (GE) covariance originating from cultural and genetic transmission operating simultaneously. In the traditional nuclear twin family (NTF) design, cultural transmission is estimated from the phenotypic covariance matrices of the mono- and dizygotic twins and their parents. Here, phenotyping is required in all family members. A more recent method is the transmitted–nontransmitted (T–NT) allele design, which exploits measured genetic variants in parents and offspring to test for effects of nontransmitted alleles from parents. This design requires two-generation genome-wide data and a powerful genome-wide association study (GWAS) for the phenotype in addition to phenotyping in offspring. We compared the power of both designs. Using exact data simulation, we demonstrate three points: how the power of the T–NT design depends on the predictive power of polygenic risk scores (PRSs); that when the NTF design can be applied, its power to detect cultural transmission and GE covariance is high relative to T–NT; and that, given effect sizes from contemporary GWAS, adding PRSs to the NTF design does not yield an appreciable increase in the power to detect cultural transmission. However, it may be difficult to collect phenotypes of parents and the possible importance of gene × age interaction, and secular generational effects can cause complications for many important phenotypes. The T–NT design avoids these complications.
Psychische Auffälligkeiten von Jugendlichen mit Adipositas in der stationären Rehabilitation
Authors: Hampel Petra , Petermann Franz , Stachow Rainer 
Published: October 2020

Zusammenfassung. Es wurden die Geschlechts- und Altersunterschiede in den selbst- und fremdbeurteilten psychischen Auffälligkeiten bei N = 142 Jugendlichen mit Adipositas in der stationären Rehabilitation untersucht. Mädchen wiesen im Selbsturteil höhere Ausprägungen in der Ängstlichkeit/Depressivität sowie den emotionalen und Verhaltensproblemen auf. Die Eltern gaben eine höhere Hyperaktivität ihrer Söhne an. Jüngere schätzten ihre Verhaltensprobleme höher ein als Ältere. Zudem wurde die klinische Stichprobe mit geschlechts- und altersgematchten Kontrollen aus der Normierungsstudie des Screenings psychischer Störungen im Jugendalter (SPS-J-II; Hampel & Petermann, 2012a ) verglichen ( N = 254). Es ergab sich ein 2.43-fach erhöhtes Risiko für auffällige Werte in der Ängstlichkeit/Depressivität bei den Jugendlichen mit Adipositas und ein signifikanter Mittelwertunterschied. Die Befunde sprechen für eine frühzeitige Diagnostik psychischer Auffälligkeiten und bedarfsgerechte Interventionen, um der Entwicklung komorbider psychischer Auffälligkeiten vorzubeugen.
A Synthesis of Observations and Models to Assess the Time Series of Sea Ice Mass Balance in the Beaufort Sea
Authors: Planck Cameron J. , Perovich Donald K. , Light Bonnie 
Published: October 2020

AbstractOver the past four decades, there has been a substantial thinning of the summer sea ice cover in the Beaufort Sea. Variations in sea ice mass balance reflect these changes and give insight to the environmental forcings which caused them. In this work, the time series results from eight Lagrangian mass balance sites that operated in the Beaufort Sea over the years 1997–2015 are analyzed. Direct measurements from the sites are combined with estimates of ice/ocean heat input to examine the roll of solar heating on ice loss, growth, and melt rates. Comparisons between ice and snow conditions and mass balance event timing, for example, surface and bottom melt onset, melt peak, and melt end, are also made. From the late 1990s to the present, a general increase in bottom melting and solar heat input to the upper ocean was observed. All sites showed a net loss of ice (ranging from 29 to 271 cm), and all but one site saw the majority of this loss from bottom melting. Bottom melt onset occurred within a relatively narrow 13‐day window between 1 and 13 June at all sites. The amount of observed bottom melt was also related to the heat deposited in the ocean available for melting, underscoring the increasingly important role of ocean thermodynamics in determining sea ice mass balance.
Groove Generation and Coalescence on a Large‐Scale Laboratory Fault
Authors: Brodsky Emily E. , McLaskey Gregory C. , Ke Chun‐Yu 
Published: October 2020

AbstractFaults are the products of wear processes acting at a range of scales from nanometers to kilometers. Grooves produced by wear are a first‐order observable feature of preserved surfaces. However, their interpretation is limited by the complex geological histories of natural faults. Here we explore wear processes on faults by forensically examining a large‐scale controlled, laboratory fault which has a maximum offset between the sides of 42 mm and has been reset multiple times for a cumulative slip of approximately 140 mm. We find that on both sides of the fault scratches are formed with lengths that are longer than the maximum offset but less than the cumulative slip. The grooves are explained as a result of interaction with detached gouge rather than as toolmarks produced by an intact protrusion on one side of the fault. The density of grooves increases with normal stress. The experiment has a range of stress of 1–20 MPa and shows a density of 10 grooves/m/MPa in this range. This value is consistent with recent inferences of stress‐dependent earthquake fracture energy of 0.2 J/m2/MPa. At normal stresses above 20 MPa, the grooves are likely to coalesce into a corrugated surface that more closely resembles mature faults. Groove density therefore appears to be an attractive target for field studies aiming to determine the distribution of normal stress on faults. At low stresses the groove spacing can be measured and contrasted with areas where high stresses produce a corrugated surface.
Attributing Causes of Future Climate Change in the California Current System With Multimodel Downscaling
Authors: Howard Evan M. , Frenzel Hartmut , Kessouri Fayçal , Renault Lionel , Bianchi Daniele , McWilliams James C. , Deutsch Curtis 
Published: October 2020

AbstractCoastal winds in the California Current System (CCS) are credited with the high productivity of its planktonic ecosystem and the shallow hypoxic and corrosive waters that structure diverse macrofaunal habitats. These winds thus are considered a leading mediator of climate change impacts in the CCS and other Eastern Boundary Upwelling systems. We use an eddy‐permitting regional model to downscale the response of the CCS to three of the major distinct climate changes commonly projected by global Earth System Models: regional winds, ocean warming and stratification, and remote water chemical properties. An increase in alongshore winds intensifies spring upwelling across the CCS, but this response is muted by increased stratification, especially during summer. Despite the seasonal shift in regional wind‐driven upwelling, basin‐scale changes are the decisive factor in the response of marine ecosystem properties including temperature, nutrients, productivity, and oxygen. Downscaled temperature increases and dissolved oxygen decreases are broadly consistent with coarse resolution Earth System Models, and these projected changes are large and well constrained across the models, whereas nutrient and productivity changes are small compared to the intermodel spread. These results imply that global models with poor resolution of coastal processes nevertheless yield important information about the dominant climate impacts on coastal ecosystems.
Characterization of weaning-induced breast involution in women: implications for young women’s breast cancer
Authors: Jindal Sonali , Narasimhan Jayasri , Borges Virginia F. , Schedin Pepper 
Published: October 2020

AbstractIn rodents, weaning-induced mammary gland involution supports increased mammary tumor incidence, growth, and progression to metastasis. Further, the protumor attributes of gland involution are COX-2 dependent and mitigated by short-duration non-steroidal anti-inflammatory drugs (NSAIDs), suggesting a potential prevention strategy. However, the transition from lactation to postweaning breast involution has not been rigorously evaluated in healthy women. Here we queried breast biopsies from healthy women (n = 112) obtained at nulliparity, lactation, and multiple postweaning time points using quantitative immunohistochemistry. We found that mammary remodeling programs observed in rodents are mirrored in the human breast. Specifically, lactation associates with the expansion of large, secretory mammary lobules and weaning associates with lobule loss concurrent with epithelial cell death and stromal hallmarks of wound healing, including COX-2 upregulation. Altogether, our data demonstrate that weaning-induced breast involution occurs rapidly, concurrent with protumor-like attributes, and is a potential target for NSAID-based breast cancer prevention.