bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics of feline hypertrophic cardiomyopathy
Authors: Gil‐Ortuño Cristina , Sebastián‐Marcos Patricia , Sabater‐Molina María , Nicolas‐Rocamora Elisa , Gimeno‐Blanes Juan R. , Fernández del Palacio María J. 
Published: March 2020

AbstractHypertrophic cardiomyopathy (HCM) is characterized by an abnormal increase in myocardial mass that affects cardiac structure and function. HCM is the most common inherited cardiovascular disease in humans (0.2%) and the most common cardiovascular disease in cats (14.7%). Feline HCM phenotype is very similar to the phenotype found in humans, but the time frame for the development of the disease is significantly shorter. Similar therapeutic agents are used in its treatment and it has the same complications, such as heart failure, thromboembolism and sudden cardiac death. In contrast to humans, in whom thousands of genetic variants have been identified, genetic studies in cats have been limited to fragment analysis of two sarcomeric genes identifying two variants in MYBPC3 and one in MYH7. Two of these variants have also been associated with human disease. The high prevalence of the reported variants in non‐affected cats hinders the assumption of their pathogenicity in heterozygotes. An in‐depth review of the literature about genetic studies on feline HCM in comparison with the same disease in humans is presented here. The close similarity in the phenotype and genotype between cats and humans makes the cat an excellent model for the pathophysiological study of the disease and future therapeutic agents.
Right ventricle assessment in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation
Authors: Pardo Sanz Ana , Santoro Ciro , Hinojar Rocío , Salido Luisa , Rajjoub Ez‐Alddin , Monteagudo Juan Manuel , García Ana , González Ariana , Hernández‐Antolín Rosana , Sánchez Recalde Ángel , Zamorano José Luis , Fernández-Golfín Covadonga 
Published: March 2020

AbstractIntroductionLimited data are available regarding the evaluation of right ventricular (RV) performance in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI).ObjectiveTo evaluate the prevalence of RV dysfunction in patients with severe AS undergoing TAVI and long‐term changes.MethodsConsecutive patients with severe AS undergoing TAVI from January 2016 to July 2017 were included. RV anatomical and functional parameters were analyzed: RV diameters, fractional area change, tricuspid annular plane systolic excursion (TAPSE), S‐wave tissue Doppler of the tricuspid annulus (RV‐S'TDI), global longitudinal strain (RV‐GLS), and free wall strain (RV‐FWS). Preprocedure and 1‐year echo were analyzed.ResultsFinal population included 114 patients, mean age 83.63 ± 6.31 years, and 38.2% women. The prevalence of abnormal RV function was high, variable depending on the parameter that we analyzed, and it showed a significant reduction 1 year after TAVI implantation: 13.9% vs 6.8% (TAPSE < 17mm), P = .04; 26.3% vs 20% (fractional area change < 35%), P = .048; 41.2% vs 29.2% (RV‐S'TDI < 9.5cm/s), P = .04; 48.7% vs 39.5% (RV‐GLS > [20]), P = .049; and 48.7% vs 28.9% (RV‐FWS > [20]), P = .03. Significant differences were noted between patients with low‐flow (LF) vs normal‐flow (NF) AS in RV dysfunction prevalence as well as in RV function recovery which is less evident in LF compared with NF patients.ConclusionsRV dysfunction is high among symptomatic AS patients undergoing TAVI, with variable prevalence depending on the echocardiographic parameter used.
Effectiveness of home care for fever treatment in older people: A case–control study compared with hospitalized care
Authors: Arai Yasuyuki , Suzuki Takao , Jeong Seungwon , Inoue Yusuke , Fukuchi Masahiko , Kosaka Yoshimichi , Nagashima Koji , Ohta Hideki 
Published: March 2020

AimTo examine whether the outcomes of fever treatment through home care differ from those through hospitalized care for older people who regularly receive home care in Japan.MethodsA retrospective survey of medical record‐based data for 679 older people who regularly received home care provided by a clinic in Japan. From these data, 61 fever cases (21 cases treated in the hospital and 40 treated at home and assigned to the hospitalized and home‐care groups, respectively) were selected for analysis through a matching process. We compared the two groups in terms of mortality rate at 90 days after fever onset, and concerning changes in respective ranks for “Degree of Independent Living for the Elderly with Disability” and “Degree of Independent Living for the Elderly with Dementia” from immediately before fever onset to 90 days after fever onset.ResultsThe mortality rate tended to be higher in the hospitalized group than in the home‐care group (33% vs. 13%, respectively, P = 0.05). The hospitalized group also had a higher proportion of patients whose disability had worsened (43% vs. 23%, respectively, P = 0.16) and a significantly higher proportion of patients whose dementia had worsened (29% vs. 6%, respectively, P = 0.03).ConclusionsOur findings suggest that home care is more effective than hospitalized care for treating fever in older people who regularly receive home care in Japan, as it leads to lower mortality and better maintenance of activities of daily living capabilities. Geriatr Gerontol Int 2020; 20: 482–487.
Evaluating the cross‐cultural validity of three family quality of life sub‐scales
Authors: Hepperlen Renee A. , Rabaey Paula , Hearst Mary O. 
Published: March 2020

AbstractBackgroundFamilies of children with disabilities often face unique challenges. Developed in a U.S. context, the Beach Center Family Quality of Life measure assesses the effectiveness of supports and services that families receive. This study examines whether items from three sub‐scales of the Beach Center instrument perform similarly for two samples, one from Lusaka, Zambia, and the second from a Midwestern U.S. state.MethodsThis cross‐sectional research used secondary data and completed hierarchical ordinal regression analyses on item‐level performance within the sub‐scales.ResultsOnly one item flagged for potential item bias with remaining items performing similarly when controlling for overall sub‐scale scores.ConclusionsThis study extends existing research on the cultural and linguistic appropriateness of the Beach Center measure, providing additional validity evidence about the internal structure of the scales. Findings indicate that these items are acceptable outcome measures for policy and programme evaluations in Zambia.
TAT‐dextran–mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes
Authors: Maeda Hideki , Kami Daisuke , Maeda Ryotaro , Murata Yuki , Jo Jun‐ichiro , Kitani Tomoya , Tabata Yasuhiko , Matoba Satoaki , Gojo Satoshi 
Published: March 2020

AbstractAcute myocardial infarction is a leading cause of death among single organ diseases. Despite successful reperfusion therapy, ischaemia reperfusion injury (IRI) can induce oxidative stress (OS), cardiomyocyte apoptosis, autophagy and release of inflammatory cytokines, resulting in increased infarct size. In IRI, mitochondrial dysfunction is a key factor, which involves the production of reactive oxygen species, activation of inflammatory signalling cascades or innate immune responses, and apoptosis. Therefore, intercellular mitochondrial transfer could be considered as a promising treatment strategy for ischaemic heart disease. However, low transfer efficiency is a challenge in clinical settings. We previously reported uptake of isolated exogenous mitochondria into cultured cells through co‐incubation, mediated by macropinocytosis. Here, we report the use of transactivator of transcription dextran complexes (TAT‐dextran) to enhance cellular uptake of exogenous mitochondria and improve the protective effect of mitochondrial replenishment in neonatal rat cardiomyocytes (NRCMs) against OS. TAT‐dextran–modified mitochondria (TAT‐Mito) showed a significantly higher level of cellular uptake. Mitochondrial transfer into NRCMs resulted in anti‐apoptotic capability and prevented the suppression of oxidative phosphorylation in mitochondria after OS. Furthermore, TAT‐Mito significantly reduced the apoptotic rates of cardiomyocytes after OS, compared to simple mitochondrial transfer. These results indicate the potential of mitochondrial replenishment therapy in OS‐induced myocardial IRI.
Temporal patterns of hospital readmissions according to disease category for patients after elective colorectal surgery
Authors: Grass Fabian , Hübner Martin , Crippa Jacopo , Lovely Jenna K. , Huebner Marianne , Larson David W. 
Published: March 2020

AbstractRationaleThe aim of this study was to identify temporal readmission patterns according to baseline disease categories to provide opportunities for targeted interventions.MethodsRetrospective analysis of consecutive adult (≥18 years) patients who underwent elective colorectal resections (2011‐2017) at Mayo Clinic Rochester, MN. A prospective administrative database including patient demographics, procedure characteristics, discharge information and specifics on 30‐day readmissions (to index facility) including timing and reasons was utilized. The ICD‐9 codes were regrouped into the main pathologies Cancer, Crohn's disease (CD)/chronic ulcerative colitis (CUC), and diverticular disease.ResultsIn total, 521 (7.2%) out of 7245 patients undergoing inpatient colorectal surgery were readmitted. In all increments of time from discharge (0‐2 days: 31.3% of all readmissions, 3‐7 days: 32.4% of all readmissions, 8‐14 days: 18% of all readmissions, and 15‐30 days: 18.3% of all readmissions), reasons for readmission differed significantly (all P < 0.001). Across all disease categories, early readmissions (within 2 days of discharge) were most likely due to ileus/obstruction (53.4% of early readmissions), whereas with 42.5%, infection was the most common cause for late readmissions (>7 days). Patients with home discharge were more likely to be readmitted earlier within the 30‐day observation period (P = 0.099), whereas patients with a longer length of index hospital stay (>7 days) were readmitted later (P = 0.080).ConclusionsReasons for readmission appear to be universal across different disease categories. Targeted educational and collaborative measures may help to mitigate the burden of hospital readmissions to index facilities.
Identification of a morning out‐of‐hospital cardiac arrest cluster of high‐incidence: towards a chrono‐preventive care strategy
Authors: Baert Valentine , Vilhelm Christian , Escutnaire Joséphine , Marc Jean‐Baptiste , Wiel Eric , Tazarourte Karim , Goldstein Patrick , Khoury Carlos El , Hubert Hervé , Génin Michaël ,   on behalf GR‐RéAC
Published: March 2020

AbstractRationale, aims, and objectivesThe human body is regulated by intrinsic factors which follow a 24‐hour biological clock. Implications of a circadian rhythm in the out‐of‐hospital cardiac arrest (OHCA) are studied but the literature is not consistent. The main objective of our study was to identify temporal cluster of high or low incidence of OHCA occurrence during a day.MethodsMulticentre comparative study based on the French national OHCA registry data between 2013 and 2017. After describing the population, the detection of significant temporal clusters of OHCA incidence was achieved using temporal scan statistics based on a Poisson model adjusted for age and gender. Then, comparisons between identified patients clusters and the rest of the population were performed.ResultsDuring the study, 37 163 medical OHCA victims were included. The temporal scan revealed a significant 3‐hour high incidence temporal cluster between 8:00 am and 10:59 am (Relative R = 1.76, P < .001). In the identified cluster, OHCA occurred more out of the home with fewer witnesses, and advanced life support was less attempted in the cluster. No difference was observed on the return of spontaneous circulation, survival at hospital admission, and survival 30 days after the OHCA or at hospital discharge.ConclusionsWe observed a three‐hour morning high incidence peak of OHCA. This high incidence could be explained by different physiological changes in the morning. These changes are well known and the evidence of a morning peak of cardiovascular disease should enable medical teams to adapt care strategy and hospital organization.
Scale‐up model of forced air‐integrated gaseous chlorine dioxide for the decontamination of lowbush blueberries
Authors: Lacombe Alison , Antosch Jeremiah G. , Wu Vivian C. H. 
Published: March 2020

AbstractGaseous chlorine dioxide (ClO2) is a promising sanitizer for frozen products because of its efficacy under nonthermal and waterless conditions. A major knowledge gap exists between laboratory trials and effectiveness at the industrial scale. To address this, a pilot study implementing a pallet‐sized fumigation container (60 harvest totes) was designed for gaseous ClO2. Fifty kilograms of blueberries were exposed to initial dose of 57.46 mg/L, representing a treatment of 2.35 mg/g of blueberries. Blueberries remained enclosed for 10 hr. Reduction of all viable cells, coliforms, yeasts, and molds were measured by plating treated samples on Tryptic Soy Agar, Violet Red Bile Agar, and Dichloran Rose Bengal Chloramphenicol Agar and compared to untreated controls. The results demonstrate that a significant reduction of 1.5 log CFU/g can be achieved against coliforms after ClO2 exposure. Our findings demonstrate a cost‐effective procedure that could be adapted to commercial processing.
A Positive Side of Deployment: Vicarious Posttraumatic Growth in U.S. Military Nurses Who Served in the Iraq and Afghanistan Wars
Authors: Doherty Mary Ellen , Scannell‐Desch Elizabeth , Bready Jennifer 
Published: March 2020

AbstractPurposeTo describe vicarious posttraumatic growth in U.S. military nurses who served in the Iraq and Afghanistan wars.DesignA cross‐sectional descriptive design was used.MethodsRespondents were asked to complete the Posttraumatic Growth Inventory (PTGI), Core Beliefs Inventory (CBI), and six open‐ended write‐in questions as an electronic survey.FindingsAppreciation of life and Personal strength were the strongest dimensions on the PTGI. This was also evident in participant responses to the open‐ended questions. The five dimensions of the PTGI were significantly correlated, indicating as growth increased in one dimension, growth increased in all dimensions. The CBI showed moderate to strong positive correlations with all items. Thus, the relationship between the total PTGI scores and the total CBI scores showed a strong, positive correlation, which indicated higher overall core belief scores associated with more growth in total PTGI scores.ConclusionsThis study provided initial evidence that some nurses who served in the Iraq and Afghanistan wars experienced posttraumatic growth. While healthcare providers need to be educated about their vulnerability when exposed to trauma, they also need to be aware of potential growth when caring for casualties.Clinical RelevanceNurses preparing to serve in war, as well as those returning, need to pay attention to their physical, psychological, emotional, and spiritual health. Following return from war deployment, the military services need to take deliberate and careful measures to ensure that no returning personnel “fall through the cracks” in getting the help they need.
Student Experience of School Screening, Brief Intervention, and Referral to Treatment
Authors: Chadi Nicholas , Levy Sharon , Wisk Lauren E. , Weitzman Elissa R. 
Published: March 2020

ABSTRACTBACKGROUNDScreening, Brief Intervention and Referral to Treatment (SBIRT) is a clinical guideline that can help delay, prevent or reduce substance use behaviors in youth. We aimed to describe the experiences of middle and high school (MS and HS) students attending a school with an SBIRT program.METHODSThis was a survey study conducted in 2 school districts that implemented SBIRT programs prior to statewide roll‐out of mandatory school SBIRT in Massachusetts, in which students were asked about past‐year substance use and then received brief counseling by a school professional. Students in grades that received SBIRT were subsequently invited to complete an electronic questionnaire about their SBIRT experience.RESULTSA total of 890 students were included in the study (63.7% MS, 36.3% HS). Experiences of school SBIRT were predominantly positive: 74.0% of participants reported that the information received was useful. Students who reported having used substances were less likely to agree that “schools should screen for substance use” than students who did not report substance use (AOR: 0.39, 95%CI: 0.29‐0.53).CONCLUSIONSMost respondents found SBIRT of value, though students with past‐year substance use were less positive about the experience. More research is needed to optimize SBIRT delivery in schools.
Interleukin 6 as a marker of depression in women with sleep apnea
Authors: Campos‐Rodriguez Francisco , Cordero‐Guevara Jose , Asensio‐Cruz Maria Isabel , Sanchez‐Armengol Angeles , Sanchez‐Lopez Veronica , Arellano‐Orden Elena , Gozal David , Martinez‐Garcia Miguel Angel 
Published: March 2020

AbstractDepression is common in women with obstructive sleep apnea (OSA), but objective markers of depression have not yet been explored in such patients. We hypothesized that inflammation and antioxidant biomarkers may be associated with depression in a cohort of OSA women. We conducted a multicentre, cross‐sectional study in 247 women diagnosed with moderate‐to‐severe OSA. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Questionnaire (HAD‐D) and defined as a score ≥11. Associations between tumour necrosis factor α (TNFα), interleukin 6 (IL‐6), C‐reactive protein (CRP), intercellular adhesion molecule 1 (ICAM‐1), catalase (CAT), superoxide dismutase (SOD) and brain‐derived neurotrophic factor (BDNF) plasma levels and depression were assessed. The women had a median (25th‐75th percentiles) age of 58 (51–65) years, body mass index (BMI) of 33.5 (29.0–38.3) Kg/m2, Epworth Sleepiness Scale (ESS) score of 10 (6–13) and apnea–hypopnea index (AHI) of 33.3 (22.8–49.3). Logistic regression analyses revealed that only IL6 levels were associated with the presence of depression (adjusted odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08–1.34), whereas linear regression further confirmed that IL6 levels were significantly associated with HAD‐D scores (β = .154; 95% CI, 0.03–0.30). Multivariate regression analysis showed that IL6 (OR, 1.22; 95% CI, 1.09–1.36), ESS (OR, 1.10; 95% CI 1.02–1.19) and physical activity <30 min/day (OR, 2.51; 95% CI, 1.25–5.05) were independent predictors of depression. Thus, we conclude that in a cohort of women with moderate‐to‐severe OSA, IL6 levels are independently associated with the presence of depression and correlate with depression scores. Low physical activity and higher ESS scores are also independent indicators of risk of depression in this population.
Incidence of postoperative complications and outcome of 48 dogs undergoing surgical management of insulinoma
Authors: Del Busto Isaac , German Alexander J. , Treggiari Elisabetta , Romanelli Giorgio , O'Connell Erin M. , Batchelor Daniel J. , Silvestrini Paolo , Murtagh Kevin 
Published: March 2020

AbstractBackgroundInformation regarding outcome of dogs undergoing surgical management for insulinoma is based on studies of a small number of dogs.ObjectivesTo report the outcomes of dogs undergoing surgery as treatment for insulinoma, the prevalence of postoperative diabetes mellitus (DM) in this group and to determine if development of DM can be predicted.AnimalsForty‐eight client‐owned dogs, with a histopathological diagnosis of insulinoma, from three European referral hospitals.MethodsRetrospective observational study. Dogs were identified from a search of electronic hospital records. Cox's regression was used to determine factors associated with postoperative survival and relapse, and logistic regression was used to determine factors associated with the development of DM.ResultsMedian survival time (MST) was 372 days (range 1‐1680 days), with dogs with stage I disease having the longest survival time. Stage I dogs had MST of 652 days (range 2‐1680 days), whereas dogs with either stage II or III disease had MST of 320 days (range 1‐1260 days;P =0.045). Postoperative hyperglycemia was identified in 33% (16/48) of the dogs, of which 9 (19% of the total population) developed persistent DM. No factors that could be used as predictors for development of DM were identified.Conclusions and clinical importanceStage of disease and postoperative hypoglycemia were associated with greater odds of relapse and decreased survival time; these could be used when discussing prognosis. In this study, postoperative DM developed more commonly than previously reported, but no factors were identified that might be useful predictors.
Concurrently wasted and stunted children 6‐59 months in Karamoja, Uganda: prevalence and case detection
Authors: Odei Obeng‐Amoako Gloria Adobea , Myatt Mark , Conkle Joel , Muwaga Brenda Kaijuka , Aryeetey Richmond , Okwi Andrew Livex , Okullo Isaac , Mupere Ezekiel , Wamani Henry , Briend André , Karamagi Charles Amnon Sunday , Kalyango Joan Nakayaga 
Published: March 2020

AbstractWe assessed prevalence of concurrently wasted and stunted (WaSt) and explored the overlaps between wasted, stunted, underweight and low mid‐upper arm circumference (MUAC) among children aged 6–59 months in Karamoja, Uganda. We also determined optimal weight‐for‐age (WAZ) and MUAC thresholds for detecting WaSt. We conducted secondary data analysis with 2015–2018 Food Security and Nutrition Assessment (FSNA) cross‐sectional survey datasets from Karamoja. Wasting, stunting and underweight were defined as <−2.0 z‐scores using WHO growth standards. Low MUAC was defined as <12.5 cm. We defined WaSt as concurrent wasting and stunting. Prevalence of WaSt was 4.96% (95% CI [4.64, 5.29]). WaSt was more prevalent in lean than harvest season (5.21% vs. 4.53%; p = .018). About half (53.92%) of WaSt children had low MUAC, and all were underweight. Younger children aged <36 months had more WaSt, particularly males. Males with WaSt had higher median MUAC than females (12.50 vs. 12.10 cm; p < .001). A WAZ <−2.60 threshold detected WaSt with excellent sensitivity (99.02%) and high specificity (90.71%). MUAC threshold <13.20 cm had good sensitivity (81.58%) and moderate specificity (76.15%) to detect WaSt. WaSt prevalence of 5% is a public health concern, given its high mortality risk. All children with WaSt were underweight and half had low MUAC. WAZ and MUAC could be useful tools for detecting WaSt. Prevalence monitoring and prospective studies on WAZ and MUAC cut‐offs for WaSt detection are recommended. Future consideration to integrate WAZ into therapeutic feeding programmes is recommended to detect and treat WaSt children.