bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant expression of lncRNA Sox2ot is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer
Authors: Zhang Keqian , Mao Tianqi , He Zhicheng , Wu Xiaojiao , Peng Yu , Chen Yanrong , Dong Yan , Ruan Zhihua , Wang Zhe 
Published: August 2020

Abstract
Background: Long non-coding RNA (lncRNA) plays an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA Sox2ot in colorectal cancer (CRC) patients. This study sought to investigate the expression level of lncRNA Sox2ot in CRC, as well as explore its association with CRC progression and prognosis.
Methods: LncRNA Sox2ot expression was measured in 117 paired CRC tissues and adjacent non-cancerous tissues using quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationship between lncRNA Sox2ot expression and clinicopathological characteristic of CRC patients was detected by Chi-square test. Lastly, relationship between the expression level of lncRNA Sox2ot and overall survival (OS) was analyzed using Kaplan–Meier analysis and univariate and multivariate analyses were evaluated by Cox regression models.
Results: The expression level of lncRNA Sox2ot in CRC tissues were significantly higher than in the adjacent non-cancerous tissues (P<0.05). In addition, high lncRNA Sox2ot expression was positively correlated with N stage, T stage, TMN stage, distant metastasis, histological differentiation grade and lymph node involvement in CRC patients (all, P<0.05). Kaplan-Meier analysis showed that patients with high expression of lncRNA Sox2ot had a shorter OS than those with low lncRNA Sox2ot expression (log rank test, P<0.001). Moreover, in univariate and multivariate Cox regression models, lncRNA Sox2ot expression was an independent prognostic factor for CRC patients.
Conclusion: LncRNA Sox2ot over-expression may serve as an unfavorable prognosis predictor for CRC patients.
A comprehensive review of deep learning applications in hydrology and water resources
Authors: Sit Muhammed , Demiray Bekir Z. , Xiang Zhongrun , Ewing Gregory J. , Sermet Yusuf , Demir Ibrahim 
Published: August 2020

AbstractThe global volume of digital data is expected to reach 175 zettabytes by 2025. The volume, variety and velocity of water-related data are increasing due to large-scale sensor networks and increased attention to topics such as disaster response, water resources management, and climate change. Combined with the growing availability of computational resources and popularity of deep learning, these data are transformed into actionable and practical knowledge, revolutionizing the water industry. In this article, a systematic review of literature is conducted to identify existing research that incorporates deep learning methods in the water sector, with regard to monitoring, management, governance and communication of water resources. The study provides a comprehensive review of state-of-the-art deep learning approaches used in the water industry for generation, prediction, enhancement, and classification tasks, and serves as a guide for how to utilize available deep learning methods for future water resources challenges. Key issues and challenges in the application of these techniques in the water domain are discussed, including the ethics of these technologies for decision-making in water resources management and governance. Finally, we provide recommendations and future directions for the application of deep learning models in hydrology and water resources.
Uncovering Active Ingredients and Mechanisms of Spica Prunellae in the Treatment of Colon Adenocarcinoma: A Study Based on Network Pharmacology and Bioinformatics
Authors: Lei Yan , Yuan Hao , Gai Liyue , Wu Xuelian , Luo Zhixiao 
Published: August 2020

Background:
As a well-known herb used in the treatment of colon adenocarcinoma
(COAD), Spica Prunellae (SP) shows favorable clinical effect and safety in China for many years,
but its active ingredients and therapeutic mechanisms against COAD remain poorly understood.
Therefore, this study aims to uncover active ingredients and mechanisms of SP in the treatment of
COAD using a combined approach of network pharmacology and bioinformatics.

Methods:
A comprehensive approach mainly comprised of target prediction, network construction,
pathway and functional enrichment analysis, and hub genes verification was adopted in the current
study.

Results:
We collected 102 compounds-related genes and 3549 differently expressed genes (DEGs)
following treatment with SP, and 64 disease-drug target genes between them were recognized. In
addition, a total of 25 active ingredients in SP were identified. Pathway and functional enrichment
analyses suggested that the mechanisms of SP against COAD might be to induce apoptosis of
colon cancer cells by regulating PI3K-Akt and TNF signaling pathways. Recognition of hub genes
and core functional modules was performed by constructing protein-protein interaction (PPI)
network, from which TP53, MYC, MAPK8 and CASP3 were found as the hub target genes that
might play an important part in therapy for COAD. Subsequently we further compared the
differential expression level and assessed the prognostic value of these four hub genes. These result
of verification suggested that SP exerted therapeutic effects against COAD via a PPI network
involving TP53, MYC, MAPK8 and CASP3.

Conclusion:
In this study, active ingredients and mechanisms of SP in the treatment of COAD
were systematically discussed, which provided the foundation for further experimental studies and
might act to promote its appropriate clinical application.
Engineering of Nanospheres Dispersed Microneedle System for Antihypertensive Action
Authors: Sardesai Mrunmayi , Shende Pravin 
Published: August 2020

Background:
A combinational therapy is mostly preferred in hypertension treatment because
of low-dose and less side effects like pretibial edema, and gastrointestinal bleeding.

Objective:
So the objective of the present work was to formulate an advanced drug delivery system in
the form of bio-responsive microneedles by incorporating nifedipine, a cardiodepressant and diltiazem,
a vasodilator for effective synergism in the treatment of hypertension.

Methods:
The pH-responsive PLGA nanospheres of diltiazem were formulated using Water-in-Oil-in-
Water (W/O/W) double emulsion and solvent-diffusion-evaporation technique. These nanospheres were
added to nifedipine-PVP mixture and then incorporated into mold to develop microneedles.

Results:
The microneedles showed the release of nifedipine almost 96.93± 2.31% for 24 h due to high
PVP solubilization. The nanospheres of diltiazem on contact with acidic pH of skin managed to form of
CO2 bubbles and increase the internal pressure to burst PLGA shell due to pore formation. The mean
blood pressure observed for the normal group was 89.58 ± 3.603 mmHg, whereas the treatment with the
new formulation significantly reduced the mean blood pressure up to 84.11 ± 2.98 mmHg in comparison
to the disease control group (109.9 ± 1.825 mm Hg).

Conclusion:
This system co-delivers the drugs nifedipine and diltiazem in hypertension and shows an
advance alternative approach over conventional drug delivery system.
Evaluation of the Technological Potential of Grape Peels Through Patent Document Analysis: Agro-industrial Waste with Biotechnological Potential
Authors: Souza Euzelia L. , Leal Ingrid L. , Umsza-Guez Marcelo A. , Machado Bruna A.S. 
Published: August 2020

Background:
Grape (Vitis vinifera L.) is consumed by old-world populations in its natural
form and is used to produce wine or juice. Currently, China is the largest grape producer in the world.
The red grapes stand out because of their phytochemical composition, more specifically their high
resveratrol levels. Resveratrol is a compound that has a number of different beneficial effects on health
and is mainly used in the food and cosmetic industries. Grape peel is a waste product and new strategies
based on nanotechnology can minimize its environmental impact and add value to this residue.

Objectives:
The first objective of this study was to evaluate the technological potential of utilizing
grape peel by researching and analyzing information extracted from patent documents filed worldwide
in order to identify the main countries that hold the research technology, the main depositors and inventors,
and the main areas of application. The second aim was to research and investigate grape peel
products that have been created using nanotechnology.

Methods:
An analysis of all patented documents related to grape peel processes, products, or different
industrial applications that may use nanotechnology was carried out. This was achieved by undertaking
a Derwent Innovation Index (DII) database search.

Results:
A total of 752 patent documents were identified in the surveyed area. These were assessed for
depositor country of origin, type of depositor, inventors, the evolution of deposits over time, and areas
of application. Only 6% of the total represented products and processes in the nanotechnology area.
There was a growth in the number of patent filings from 2015, which showed that the researched area
is a current and developing technology with new application possibilities. The main depositing countries
were China, the United States, and Japan, which dominate the researched technology. The identified
documents discussed using the grape peel to develop new food, medical and dental products.

Conclusion:
Over the last few years, different approaches have been suggested for the production of
nanoproducts based on grape peel. The results from this study showed that although incipient, nanotechnology
is a promising area of research that can be explored by universities and companies because
the products could have significant positive characteristics and, even though they are made out of a
byproduct, have great application potential.
Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation
Authors: Yu Kun-Hsing , Lee Tsung-Lu Michael , Yen Ming-Hsuan , Kou S C , Rosen Bruce , Chiang Jung-Hsien , Kohane Isaac S 
Published: August 2020

Background
Chest computed tomography (CT) is crucial for the detection of lung cancer, and many automated CT evaluation methods have been proposed. Due to the divergent software dependencies of the reported approaches, the developed methods are rarely compared or reproduced.

Objective
The goal of the research was to generate reproducible machine learning modules for lung cancer detection and compare the approaches and performances of the award-winning algorithms developed in the Kaggle Data Science Bowl.

Methods
We obtained the source codes of all award-winning solutions of the Kaggle Data Science Bowl Challenge, where participants developed automated CT evaluation methods to detect lung cancer (training set n=1397, public test set n=198, final test set n=506). The performance of the algorithms was evaluated by the log-loss function, and the Spearman correlation coefficient of the performance in the public and final test sets was computed.

Results
Most solutions implemented distinct image preprocessing, segmentation, and classification modules. Variants of U-Net, VGGNet, and residual net were commonly used in nodule segmentation, and transfer learning was used in most of the classification algorithms. Substantial performance variations in the public and final test sets were observed (Spearman correlation coefficient = .39 among the top 10 teams). To ensure the reproducibility of results, we generated a Docker container for each of the top solutions.

Conclusions
We compared the award-winning algorithms for lung cancer detection and generated reproducible Docker images for the top solutions. Although convolutional neural networks achieved decent accuracy, there is plenty of room for improvement regarding model generalizability.
RADIVOJE KONSTANTINOVIĆ SOBRE JORGE LUIS BORGES
Authors: Dickov Vesna 
Published: August 2020

En este artículo nos ocupamos del papel de Radivoje Konstantinović en la recepción interpretativa de la obra literaria del escritor argentino Јorge Luis Borges en el área de la lengua serbia. En este sentido, el campo de nuestro interés está compuesto por varios textos (prefacios, postfacios, ponencias presentadas en las reuniones científicas internacionales) publicados por Radivoje Konstantinović durante la segunda mitad del siglo XX en ediciones particulares impresas en el idioma serbio. Estos textos se presentan de una manera crítica, con respecto al criterio cronológico, a fin de señalar los parámetros cualitativos y cuantitativos básicos que son característicos para esta clase de recepción (tipo de textos, fecha y lugar de publicación, distribución, editores), con el objetivo de determinar la importancia de la influencia de Radivojе Konstantinovic en la formación y modificación del horizonte de expectativas de los lectores en relación con la aceptación de las creaciones literarias de Jorge Louis Borges en el área de la lengua serbia.
SOBRE LA INTERPRETACIÓN SIMBÓLICA Y TRADUCCIÓN DEJ.L. BORGES EN RADIVOJE KONSTANTINOVIĆ
Authors: Trivić Aneta 
Published: August 2020

Este trabajo tiene doble objetivo: por un lado representamos los temas, símbolos y metáforas empleadas por J. L. Borges en su obra prosaicay dirigimos nuestra atención hacia su recepción e interpretación en el ámbito serbio (nos centramos en primer lugar ellaberinto como símbolo de la construcción espacio-temporal, psicológica, existencial u onírica). Paralelamente exploramos las críticas y observaciones que sobre Borges ha elaborado profesor Radivoje Konstantinović, uno de los mejores conocedores de la obra borgeana. El segundo objetivo que perseguimos concierne el análisis traductológico: examinamos las soluciones y métodos traductológicos empleados en textos serbios por Konstantinović. En tal análisis partimos de la estructuración sistemática y jerárquica del sistema lingüístico y comentamos las soluciones gramáticas y estilísticas interesantes para los serbio hablantes. El corpus principal está basado en el relato La casa de Asterión y su traducción serbia Asterionovdom (ZUNS). En la investigación nos apoyamos en los métodos de interpretación simbólica/metafórica (cuando representamos y analizamos ideas y símbolos dominantes en la obra prosaica de J.L. Borges), análisis lingüístico y traductológico del texto en prosa y análisis contrastivo (cuando utilizamos los corpus paralelos para comparar las distintas soluciones traductológicas del mismo texto).
LE CHANGEMENT DE SENS DES LEXEMES EN DIACHRONIE
Authors: Miljković Ivana 
Published: August 2020

Dans le cadre d’une analyse diachronique nous nous proposons d’étudier, du point de vue de la sémantique, les lexèmes français qui ont subi des changements de sens. L’objectif de nos recherches est de mettre en évidence les différents types d’évolutions du sens, tant pour les substantifs que pour les adjectifs et les verbes. Parfois le sens d’origine est perdu, parfois il continue de coexister avec un sens nouveau, parfois il a perdu son caractère polysémique, etc. Et les raisons de ces évolutions de sens sont variables, depuis un simple changement d’usage jusqu’à une évolution de vision sociétale. En nous basant sur un corpus incluant les lexèmes « panier », « compter/conter », « voler », « vilain », ou encore « calcul » nous allons nous attacher à caractériser les différents types d’évolution et leurs raisons historiques. Nous évoquerons toutes les relations sémantiques en diachronie, en insistant particulièrement sur le changement de sens, la polysémie et l’homonymie.
ANALYSIS OF SOMATOTYPE OF TOP YOUNG RACE WALKERS BY MEANS OF THE HEATH-CARTER METHOD
Authors: Stanković Daniel , Raković Aleksandar , Petković Emilija , Petrović Ivana , Savanović Vladimir 
Published: August 2020

The aim of this study was to analyze the somatotypes of top young race walkers in Europe. For the analysis of their somatotype, the Heath-Carter method was used. By applying digital anthropometry and computer programs, the somatotypes of 44 participants aged 15 to 17, sports walkers of both genders (21 boys and 23 girls), were determined. Based on the analysis, extensive data were obtained on the somatotype of top young race walkers, where a large number of groups emerged. Among the boys, there are three groups of somatotypes: ectomorph-mesomorph (1.8-6.7-4.1), mesomorph-ectomorph (1.4-4.2-5.6) and mesomorph-ectomorph (1.7-5.1-5.1). The results showed that as many as 7 different groups of somatotypes can be found among the girls: endomorph-mesomorph (4.5-7.9-2.4), ectomorph-mesomorph (3.5-6.4-4.3), central (3.1-3.7-4.0), balanced mesomorph (3.5-6.0-3.6), balanced ectomorph (2.7-1.6-6.4), mesomorph-ectomorph (3.3-5.0-4.7), mesomorph-ectomorph (2.7-4.4-5.2). The analyzed somatotypes of top young race walkers indicate the considerable heterogeneity of the group of participants. The intermediate somatotype among the males is defined as ectomorph-mesomorph (1.7-6.1-4.5), whereas the intermediate somatotype among the females is defined as a central somatotype (3.5-5.5-4.0).
Estado integral de derecho y derechos humanos. Propuesta de actualización
Authors: De Silva Gutiérrez Gustavo 
Published: August 2020

En estas líneas se analiza la noción de “estado de derecho” y la evolución del mismo con las características que en cada momento lo conformaron, desde el estado liberal, pasando por el estado social, el pretendido estado democrático, hasta el actual estado constitucional de derecho. Se proponen elementos adicionales buscando mayor plenitud del mismo, mediante el fortalecimiento institucional, su integración en todo el derecho y la necesaria participación social en el sistema de estado de derecho, para alcanzar una nueva etapa denominada estado integral de derecho.
El efecto global de la actual revolución tecnológica 4ª revolución industrial y la industria 4.0 en acción
Authors: Orellana-Daube David Francisco 
Published: August 2020

La motivación para investigar sobre la 4ª Revolución Industrial, es que ya está activamente presente en muchos países desarrollados y en mucho menor magnitud en paises de Latinoamérica.
La comunidad científica Latinoamericana no se ha abocado a investigar con la profundidad que los cambios que está introduciendo la 4ª Revolución Industrial requieren, dado el bajo apoyo de las instituciones universitarias. Esto generará importantes beneficios a la comunidad científica ya que expone las diferentes tecnologías que componen esta revolución para su profunda aplicación, enseñanza e interrelación.
Este trabajo se dividirá en tres capítulos. El primero, considera un análisis las anteriores revoluciones hsta la cuarta revolución industrial describiendo las tendencias tecnológicas. El segundo, señala los elementos inherentes a la industria 4.0 y las modificaciones del requerimiento de los talentos. El tercer capítulo, analiza la relación entre la cuarta revolución industrial y el área de recursos humanos de empresas.
Como resultados relevantes hay que destacar que la tecnología está impulsando cambios e innovaciones disruptivas que están modificando la realidad actual. Por otro lado, resaltar que la gestión del recurso humano de las organizaciones no se está adaptando a las nuevas exigencias y requerimientos del talento a incorporar a las organizaciones latinoamericanas.
Las implicancias prácticas de la investigación para este paper señalan que no incorporarse a estos nuevos procesos tecnológicos de la industria 4.0, puede implicar pobreza e importantes desventajas para los países latinos.
The Right Stuff: Are Not-For-Profit Managers Really Different?
Authors: Fiolleau Krista , Libby Theresa , Thorne Linda 
Published: August 2020

ABSTRACT
In response to public pressure for accountability in the not-for-profit (NFP) sector, attempts have been made to adopt for-profit controls. These have generated mixed results. While many have argued that employees attracted to the NFP sector are “different,” little prior empirical evidence backs up this claim. To address this gap, we review the literature to identify claimed individual characteristics that might differ and use the survey method to examine whether these differences exist between the groups of responding managers working in the NFP and for-profit sectors. NFP respondents exhibit lower levels of narcissism, lower levels of entitlement, less extroversion, and a more externally oriented locus of control than their for-profit counterparts. In exploratory multivariate analysis, best predictors of NFP membership include extroversion, locus of control, conscientiousness, and moral reasoning. Rather surprisingly, the groups did not differ on altruism or tolerance for ambiguity. Implications for control system design are discussed.
PENGARUH MORFOLOGI DAN LITOLOGI KAWASAN KARST KABUPATEN REMBANG TERHADAP POTENSI HUNIAN GUA PRASEJARAH [THE INFLUENCE OF MORPHOLOGY AND LITHOLOGY OF REMBANG KARST ON THE POTENTIAL OF PREHISTORIC CAVE DWELLINGS]
Authors: Wibowo Hari , Yuwono J.S.E. , Nurani Indah Asikin 
Published: August 2020

Kawasan karst di Kabupaten Rembang adalah bagian dari Karst Perbukitan Rembang yang membentang dari Jawa Tengah hingga ke Pulau Madura. Di bagian Jawa lainnya terdapat pula barisan karst Gunung Sewu sebagai salah satu kawasan karst Pegunungan Selatan Jawa. Tidak seperti situs-situs arkeologi di Gunung Sewu yang telah diteliti secara intensif, kawasan karst Rembang di gugusan utara belum banyak diteliti. Hal inilah yang menggaris bawahi pentingnya penelitian arkeologi di kawasan karst di perbukitan Rembang, yaitu untuk menjajaki potensi gua-guanya sebagai hunian prasejarah. Penelitian ini menggunakan metode deskriptif dengan penalaran induktif, dengan memakai variabel potensi gua, dan dilakukan dengan teknik survei gemorfologis dan arkeologis. Hasil survei kemudian dibagi menjadi tiga variabel pengharkatan, yaitu kandungan arkeologis gua, aksesibilitas, dan morfologi gua. Dalam penelitian lapangan terdapat 41 titik gua yang menjadi objek pengamatan, dan beberapa di antara gua-gua tersebut memenuhi tingkat probabilitas untuk dihuni. Namun demikian, tentu saja untuk membuktikan gua-gua ini benar-benar dihuni atau tidak pada masa prasejarah diperlukan penelitian lebih lanjut. Lebih lanjut, jika dibandingkan dengan segmen-segmen di sebelah barat dan timurnya, potensi arkeologi kawasan karst Rembang, dalam pengertian situs-situs guanya, termasuk rendah.
The karst region in Kabupaten Rembang is part of the Rembang Karst Zone that stretches from Central Java to Madura Island. Another mountain range of karst, the Gunung Sewu, lies on the southern region of Java. Unlike the archeological sites of Gunung Sewu that have been intensively investigated, the Rembang karst region in the northern ranges has not been much studied. This underlines the importance of archeological research in the karst region of Rembang, which is to explore the potentiality of its caves as prehistoric dwellings. This research employs descriptive method with inductive reasoning, using potential variables of a cave, and carried out with geomorphological and archaeological survey techniques. Survey results are further divided into three criteria, i.e. archaeological findings in caves, accessibility, and cave morphology. The field observation was focussed on 41 caves, and several of them indicated the probability of inhabitation. Nevertheless, further researches are required to prove whether these caves were inhabited or not during the prehistoric period. Furthermore, in terms of cave sites when compared to the west and east segments, the archaeological potency of Rembang karst regions is low.