bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation
Authors: Milios Joanne E. , Ackland Timothy R. , Green Daniel J. 
Published: May 2020

Abstract

Introduction
Pelvic floor muscle (PFM) training for postprostatectomy incontinence is considered a first line approach to rehabilitation, but PFM training for erectile dysfunction (ED) after surgery is less well known. With more than 1.4 million new cases diagnosed globally per year, there is a need for non-invasive options to assist sexual dysfunction recovery.

Aim
Commencing preoperatively and using both fast and slow twitch fibre training performed in standing postures, new protocols were developed to address clinical presentations with aims to reduce ED and impact on quality of life (QoL). Comparisons with “usual care” PFM training, prerehabilitation and postrehabilitation were then assessed.

Methods
A randomised controlled trial of 97 men undergoing radical prostatectomy (RP) were allocated to either a control group (n = 47) performing “usual care” of 3 sets/d PFMT or an intervention group (n = 50), performing 6 sets/d in standing, commencing 5 weeks before RP.

Outcome measures
Participants were assessed preoperatively and at 2, 6, and 12 weeks after RP using the Expanded Prostate Cancer Index Composite for Clinical Practice, International Index of Erectile Function-5, and real time ultrasound measurements of PFM function.

Results
At all time points, there was a significant difference (P&lt; 0.05) between groups; however, the only time point where this difference was clinically relevant was at 2 weeks after RP, with the intervention group reporting less distress in the Expanded Prostate Cancer Index Composite for Clinical Practice QoL outcome. Secondary measures of EPIC-EF and real time ultrasound PFM function tests demonstrated improvement over all time points in both groups with lower bothersome scores in the intervention group.

Conclusions
Early PFM training reduces early QoL impact for postprostatectomy ED, with faster return to continence enabling earlier commencement of penile rehabilitation. While our 12-week protocol and sample size was not powerful enough to demonstrate conclusive benefits of early PFM training for ED, PFM intervention after RP over longer times has been supported by others.
Milios JE, Ackland TR, Green DJ. Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation. J Sex Med 2020;8:414–421.
Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors
Authors: Santos-Moreno Pedro , Castro Carlos Alberto , Villarreal Laura , Buitrago Diana 
Published: May 2020

Abstract

Introduction
Rheumatoid arthritis (RA) is a chronic and progressive pathology, present in between 0.5% and 1% of adults. Sexual disorders (SDs) occur in between 31% and 70% of all patients with RA.

Aim
To establish the associated risk factors and the prevalence of SDs in a group of patients with RA.

Methods
An analytical cross-sectional study was performed, evaluated with the Diagnostic and Statistical Manual of Mental Disorders-V tool. The related factors and the activity of the disease were explored. A multivariate logistic regression analysis was conducted.

Main Outcome Measure
The prevalence of SDs was 29.6%. There was an association between the presence of SDs and gender (women; odds ratio [OR]: 0.6, 95% CI: 0.4–0.8), age (OR: 1.4, 95% CI: 1.1–1.8), psychological alterations (OR: 12.1, 95% CI: 5.9–27.2), and Disease Activity Score 28 (OR: 1.6, 95% CI: 1.2–2).

Results
A total of 1,436 patients, with a median age of 56 years, were analyzed.

Conclusion
SDs are present in a third of patients with RA. Among the factors associated with SDs were the activity of the disease, presence of mood disorders, psychiatric disorders, alcoholism, and concomitant autoimmune pathologies. These findings suggest the necessity of a multidisciplinary approach to properly manage RA, as well as an enhancement in communication channels between the health professional team and the patient.
Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in the United Kingdom
Authors: Jacob Louis , Smith Lee , Butler Laurie , Barnett Yvonne , Grabovac Igor , McDermott Daragh , Armstrong Nicola , Yakkundi Anita , Tully Mark A. 
Published: May 2020

Abstract

Background
On 23rd March 2020, the UK government released self-isolation/social distancing guidance to reduce the risk of transmission of SARS-CoV-2. The influence such guidance has on sexual activity is not known.

Aim
To investigate levels and correlates of sexual activity during COVID-19 self-isolation/social distancing in a sample of the UK public.

Methods
This paper presents preplanned interim analyses of data from a cross-sectional epidemiological study, administered through an online survey.

Outcomes
Sexual activity was measured using the following question: “On average after self-isolating how many times have you engaged in sexual activity weekly?” Demographic and clinical data were collected, including sex, age, marital status, employment, annual household income, region, current smoking status, current alcohol consumption, number of chronic physical conditions, number of chronic psychiatric conditions, any physical symptom experienced during self-isolation, and number of days of self-isolation/social distancing. The association between several factors (independent variables) and sexual activity (dependent variable) was studied using a multivariable logistic regression model.

Results
868 individuals were included in this study. There were 63.1% of women, and 21.8% of adults who were aged between 25 and 34 years. During self-isolation/social distancing, 39.9% of the population reported engaging in sexual activity at least once per week. Variables significantly associated with sexual activity (dependent variable) were being male, a younger age, being married or in a domestic partnership, consuming alcohol, and a higher number of days of self-isolation/social distancing.

Clinical Implications
In this sample of 868 UK adults self-isolating owing to the COVID-19 pandemic, the prevalence of sexual activity was lower than 40%. Those reporting particularly low levels of sexual activity included females, older adults, those not married, and those who abstain from alcohol consumption.

Strength and Limitations
This is the first study to investigate sexual activity during the UK COVID-19 self-isolation/social distancing. Participants were asked to self-report their sexual activity potentially introducing self-reporting bias into the findings. Second, analyses were cross-sectional and thus it is not possible to determine trajectories of sexual activity during the current pandemic.

Conclusion
Interventions to promote health and well-being during the COVID-19 pandemic should consider positive sexual health messages in mitigating the detrimental health consequences in relation to self-isolation/social distancing and should target those with the lowest levels of sexual activity.
COVID-19 and ophthalmology: an underappreciated occupational hazard
Authors: Kuo Irene C. , O’Brien Terrence P. 
Published: May 2020

AbstractThe proximity required of a thorough biomicroscopic slit-lamp examination may put ophthalmologists at increased risk for respiratory-borne infection with SARS-CoV-2. Conjunctivitis has been described in a few patients with COVID-19 and other coronavirus syndromes. Although SARS-CoV-2 has been detected in the conjunctival secretions or tears of patients with COVID-19 and conjunctivitis, transmission of infection through respiratory droplets to ophthalmologists without eye protection or masks may be the bigger concern.
Allometric equations for the invasive vine air potato (Dioscorea bulbifera) in its exotic range in Florida
Authors: Rayamajhi Min B. , Rohrig Eric , Tipping Philip W. , Pratt Paul D. , Leidi Jorge G. 
Published: May 2020

AbstractNondestructive means for estimating air potato (also known as air yam; Dioscorea bulbifera L.) biomass will help gauge its management efficacy over time. We developed allometric equations to estimate total and fractional biomass components and densities of aerial bulbils and underground tubers of field-grown D. bulbifera in Florida. We selected four naturally infested sites representing its southern, central, and northern distribution in Florida and measured three independent variables (vine densities, stem diameters, and top heights) of 84 (21 site−1) discrete D. bulbifera patches during late October to early December of 2012. We destructively harvested D. bulbifera biomass, sorted by tubers, stems, leaves, and bulbils; counted units of bulbils and underground tubers (dependent variables); and dried to a constant weight. Mean percentages of tuber, stem, leaf, and bulbil fractions in total biomass were 42.0, 15.6, 26.0, and 16.4, respectively. We developed a parameterized multiplicative prediction model and regression equation for each dependent variable. Slopes of relationships among independent and dependent variables varied by biomass and density (bulbil and tuber) of plant components. Multiplied values of independent variables: all three for total, tuber, stem, and leaf biomass; two (vine base diameter*patch height) for bulbil biomass; two (vine density*patch height) for bulbil density; and only one (stem density) for tuber density provided best (R2-based) prediction values. These models will provide nondestructive methods for estimating biomass components and density of vegetative propagules of naturally growing D. bulbifera. Models are critical for understanding the performance of D. bulbifera in its exotic range, estimating biomass to project control costs, and comparing biomass components and bulbil/tuber densities during pre- and postmanagement periods to gauge control efficacy.
Getting a (big) data-based grip on ideological change. Evidence from Belgian Dutch
Authors: Grondelaers Stefan , Speelman Dirk , Lybaert Chloé , van Gent Paul 
Published: May 2020

AbstractIn this paper we introduce a computationally enriched experimental tool designed to investigate language ideology (change). In a free response experiment, 211 respondents returned three adjectives in reaction to the labels for five regional varieties, one ethnic variety and two supra-regional varieties of Belgian Dutch, as well as the standard accent of Netherlandic Dutch. Valence information (pertaining to the positive/negative character of the responses) and big data–based distributional analysis (to detect semantic similarity between the responses) were used to cluster the response adjectives into 11 positive and 11 negative evaluative dimensions. Correspondence analysis was subsequently used to compute and visualize the associations between these evaluative dimensions and the investigated language labels, in order to generate “perceptual maps” of the Belgian language repertoire. Contrary to our expectations, these maps unveiled not only the dominant value system which drives standard usage, but also the competing ideology which frames the increasingly occurring non-standard forms. In addition, they revealed a much richer stratification than the “one variety good, all other varieties bad” dichotomy we had anticipated: while VRT-Dutch remains the superior (albeit increasingly virtual) standard for Belgian Dutch, the stigmatized colloquial variety Tussentaal is gradually being accepted as a practical lingua franca, and the Ghent-accent is boosted by modern prestige (dynamism) features. Even more crucially, separate perceptual maps for the older and younger respondents lay bare generational change: there is a growing conceptual proximity between VRT-Dutch and Tussentaal in the younger perceptions.
Cosmogenic10Be and36Cl geochronology of cryoplanation terraces in the Alaskan Yukon-Tanana Upland
Authors: Nyland Kelsey E. , Nelson Frederick E. , Figueiredo Paula M. 
Published: May 2020

ABSTRACTCryoplanation terraces are prominent but enigmatic landforms found in present and past periglacial environments. Geomorphologists have debated for more than a century over processes involved in the formation of these elevated, step-like, bedrock features. Presented here are the first numerical surface exposure ages and scarp retreat rates from cryoplanation terraces in the Yukon-Tanana Upland (YTU) in Alaska, part of unglaciated eastern Beringia, obtained from terrestrial cosmogenic nuclides (TCN) in surface boulders. Ages comprise six10Be TCN ages from two terrace treads near Eagle Summit and six36Cl ages from two treads on Mt. Fairplay. Based on these exposure ages, scarps at both locations were last actively eroding from 49 to 22.4 ka. Both locations exhibit time-transgressive development, particularly near scarp-tread junctions. Boulder exposure ages and distances between sampled boulder locations were used to estimate scarp retreat rates of 0.11 to 0.56 cm/yr. These numerical exposure ages presented here demonstrate that the cryoplanation terraces in the YTU are diachronous surfaces actively eroding during multiple cold intervals. With these results, hypotheses for cryoplanation terrace formation are discussed and evaluated for the YTU, including those based on geologic structure, nivation, and the influence of permafrost.
Dietary patterns and relative expression levels of PPAR-γ, VEGF-A and HIF-1α genes in benign breast diseases: case–control and consecutive case-series designs
Authors: Asemani Sanaz , Montazeri Vahid , Foroutan-Ghaznavi Mitra , Pirouzpanah Seyed-Sajjad , Baradaran Behzad , Jafari Sahar , Barzegar Ali , Shanehbandi Dariush , Asadi Nahideh , Pirouzpanah Saeed 
Published: May 2020

AbstractWe aimed to study dietary patterns in association with the relative expression levels of PPAR-γ, vascular endothelial growth factor-A (VEGF-A) and hypoxia-inducible factor-1α (HIF-1α) in women with benign breast disease (BBD). The study design was combinative, included a case-series and case–control compartments. Initially, eligible BBD patients (n 77, aged 19–52 years old) were recruited at Nour-Nejat hospital, Tabriz, Iran (2012–2014). A hospital-based group of healthy controls was matched for age (n 231, aged 20–63 years old) and sex. Dietary data were collected using a valid 136-item FFQ. Principal component analysis generated two main components (Kaiser–Meyer–Olkin = 0·684), including a Healthy pattern (whole bread, fruits, vegetables, vegetable oils, legumes, spices, seafood, low-fat meat, skinless poultry, low-fat dairy products, nuts and seeds) and a Western pattern (starchy foods, high-fat meat and poultry, high-fat dairy products, hydrogenated fat, fast food, salt and sweets). High adherence to the Western pattern increased the risk of BBD (ORadj 5·59; 95 % CI 2·06, 15·10; P < 0·01), whereas high intake of the Healthy pattern was associated with a 74 % lower risk of BBD (95 % CI 0·08, 0·81; P < 0·05). In the BBD population, the Western pattern was correlated with over-expression of HIF-1α (radj 0·309, P < 0·05). There were inverse correlations between the Healthy pattern and expressions of PPAR-γ (radj −0·338, P < 0·05), HIF-1α (radj −0·340, P < 0·05) and VEGF-A (radj −0·286, P < 0·05). In conclusion, new findings suggested that the Healthy pattern was associated inversely with the risk of BBD, and this could be correlated with down-regulation of PPAR-γ, VEGF-A and HIF-1α genes, which might hold promise to preclude BBD of malignant pathological transformation.
Appraisal of nitric oxide priming to improve the physiology of bread wheat
Authors: Bibi Asia , Qureshi Sadia , Shehzadi Iram , Amjad Muhammad Shoaib , Azhar Nosheen , Batool Tahira , Firdous Sadiqa , Khan Muhammad , Shokat Sajid 
Published: May 2020

AbstractSeed priming is a pre-sown treatment and it is often used to improve the performance of plants in any environment, especially germination. In the current study, various concentrations of nitric oxide (NO) were used to evaluate its role for the induction of physiological variations within seven different wheat (Triticum aestivum L.) genotypes. Two experiments were conducted during 2013 and 2014 and the data were statistically analysed for significance. All these genotypes after treatment with sodium nitroprusside (SNP) as NO donor at 10−4 and 10−5 M concentrations were sown following randomized complete block design with triplicates in the fields of District Muzaffarabad, Pakistan. The concentration of NO at 10−4 M showed promising results and most of the studied characters were found improved compared to control. Wheat varieties primed with 10−4 M SNP showed highest germination speed and germination percentage. NARC-2011 and Uqab-2002 showed much improvement in physiological attributes at both concentrations of NO priming. However, Uqab-2002 and Punjab-2011 showed a significant increase in chlorophyll contents and leaf moisture content with 10−4 and 10−5 M SNP priming compared to control. Highest relative water content was observed within unprimed Lasani, whereas the relative injury was found to be decreased at 10−4 M SNP primed Faisalabad-2008. Wheat varieties Punjab-2011 and Faisalabad-2008 showed the highest increase in grain yield and biological yield by 10−4 M SNP. Hence, it is concluded that sowing of crops after priming at 10−4 M NO concentration can improve the germination, biochemistry and physiology that ultimately lead to an increase in crop yield.
The role of homofermentative and heterofermentative lactic acid bacteria for alfalfa silage: a meta-analysis
Authors: Blajman J. E. , Vinderola G. , Páez R. B. , Signorini M. L. 
Published: May 2020

AbstractLactic acid bacteria (LAB) are usually employed as alfalfa silage inoculants to obtain high-quality feed for animal husbandry. However, the effects of these inoculants are still unclear and need to be studied extensively. Therefore, the objective of this meta-analysis was to quantitatively summarize published research studies that assess the effects of homofermentative (HoLAB) and heterofermentative lactic acid bacteria (HeLAB) on fermentation parameters, nutritive value, microbiological composition and aerobic stability of alfalfa silage. PubMed, ScienceDirect and Scopus have been screened for articles published from 1980 to 2018. The criteria for inclusion were: randomized and controlled trials using alfalfa silage and published in peer-reviewed journals. It was found that inoculation with LAB decreased silage pH, neutral detergent fibre, acid detergent fibre and ammoniacal nitrogen, while it increased dry matter and crude protein compared to control in the pooled raw mean difference random-effect model. Additionally, LAB inoculation decreased acetate, propionate, ethanol and butyrate concentrations, whereas it increased lactate. In addition, inoculants reduced the counts of yeasts and moulds. Lastly, LAB inoculation improved aerobic stability. To the best of our knowledge, this is the first meta-analysis that aims at comparing the application of HoLAB and HeLAB for alfalfa silage. In the pool estimate, positive effects attributable to the application of microbial silage inoculants were found in most of the evaluated parameters; supporting the importance of applying both types of inoculants to improve forage preservation for the livestock industry.
Internal Labor Markets, Wage Convergence, and Investment
Authors: Silva Rui C. 
Published: May 2020

AbstractI document wage convergence in conglomerates using detailed plant-level data: Workers in low-wage industries collect higher-than-industry wages when the diversified firm also operates in high-wage industries. I confirm this effect by exploiting the implementation of the North American Free Trade Agreement (NAFTA) and changes in minimum wages at the state level as sources of exogenous increases in wages in some plants. I then track the evolution of wages of the remaining workers of the firm, relative to workers of unaffiliated plants. Plants where workers collect higher-than-industry wages operate with higher capital intensity, suggesting that internal labor markets may affect investment decisions in internal capital markets.
Baltic cod endohelminths reflect recent ecological changes
Authors: Setyawan A.C. , Jensen H.M. , Kania P.W. , Buchmann K. 
Published: May 2020

Abstract
We suggest helminthological investigations of cod as a supplement to traditional biological and hydrographical methods for elucidation of ecological changes in the Baltic Sea. It is under discussion if oxygen deficit or seal abundance should explain the present critical situation of Baltic cod. A comparative investigation of endoparasitic helminths in Baltic cod (Gadus morhua), captured in the same marine habitat with an interval of 35 years (1983/2018) recorded 11 species of helminths comprising trematodes (Hemiurus luehei, Podocotyle atomon, Lepidapedon elongatum), nematodes (Contracaecum osculatum, Hysterothylacium aduncum, Capillaria gracilis, Cucullanus cirratus), cestodes (Bothriocephalus sp.) and acanthocephalans (Echinorhynchus gadi, Pomphorhynchus laevis, Corynosoma semerme). Significant prevalence and intensity increases were recorded for third-stage larvae of the nematode C. osculatum (liver location) and larvae of C. semerme (encapsulated in viscera). Both parasite species use grey seal as their final host, indicating the recent expansion of the Baltic seal population. A lower E. gadi intensity and an increased prevalence of L. elongatum of small cod (31–40 cm body length) suggest a lowered intake of amphipods (intermediate host) and elevated ingestion of polychaetes, respectively, but no significant changes were seen for other helminths.
A conceptual tool for environmentally benign design: development and evaluation of a “proof of concept”
Authors: Acharya Shakuntala , Chakrabarti Amaresh 
Published: May 2020

AbstractDesign is a decision-making process for which knowledge is a prerequisite. Most decisions are taken at the conceptual stage and have pronounced influence on the final design. The literature, therefore, recommends the incorporation of sustainability criteria, such as environment, at this stage. Difficulty in performing life cycle assessment (LCA) due to low availability of information at the conceptual stage for evaluation and highly abstract nature of solutions, inadequate incorporation of DfE (Design for Environment) guidelines and LCA reports into the design process, and a lack of effective communication of the same to the designers for prompt decision-making are major motivations for the development of a support. This paper discusses a “conceptual Tool for environmentally benign design” – concepTe – that supports designers in decision-making during the conceptual design stage, by offering environmental impact (EI) estimates of abstract solutions with associated uncertainty, for evaluation and selection of the most environmentally benign solution as concept. The EI estimates are calculated by a module in the tool based on a proposed EI estimation method, which requires the support of a knowledge base to fetch appropriate LCA information corresponding to the design element being conceptualized. This knowledge base is grounded in the domain-agnostic SAPPhIRE model ontology, allows semantic operability of the knowledge, and offers the results to the designers in a familiar domain language to aid decision-making. A “proof of concept” of the tool is developed for application in design of building in the AEC (Architectural design, Engineering, and Construction) domain. Further, empirical studies are conducted to evaluate the effectiveness of the “proof of concept” to support decision-making and results are found favorable. The paper also discusses the future scope for further development of the tool into a holistic design decision-making platform.