bluuebunny/crossref_metadata_2025_split huggingface dataset:
A panchromatic spatially resolved analysis of nearby galaxies – II. The main sequence – gas relation at sub-kpc scale in grand-design spirals
Authors: Morselli L , Rodighiero G , Enia A , Corbelli E , Casasola V , Rodríguez-Muñoz L , Renzini A , Tacchella S , Baronchelli I , Bianchi S , Cassata P , Franceschini A , Mancini C , Negrello M , Popesso P , Romano M 
Published: June 2020

ABSTRACT
In this work, we analyse the connection between gas availability and the position of a region with respect to the spatially resolved main-sequence (MS) relation. Following the procedure presented in Enia et al. (2020), for a sample of five face-on, grand design spiral galaxies located on the MS we obtain estimates of stellar mass and star formation rate surface densities (Σ⋆ and ΣSFR) within cells of 500 pc size. Thanks to H i 21cm and 12CO(2–1) maps of comparable resolution, within the same cells we estimate the surface densities of the atomic (ΣH i) and molecular ($\Sigma _{\rm {H_2}}$) gas and explore the correlations among all these quantities. Σ⋆, ΣSFR, and $\Sigma _{\rm {H_2}}$ define a 3D relation whose projections are the spatially resolved MS, the Kennicutt–Schmidt law and the molecular gas MS. We find that $\Sigma _{\rm {H_2}}$ steadily increases along the MS relation and is almost constant perpendicular to it. ΣH i is nearly constant along the MS and increases in its upper envelope. As a result, ΣSFR can be expressed as a function of Σ⋆ and ΣH i, following the relation log ΣSFR = 0.97log Σ⋆ + 1.99log ΣH i − 11.11. We show that the total gas fraction significantly increases towards the starburst regions, accompanied by a weak increase in star formation efficiency. Finally, we find that H2/H i varies strongly with the distance from the MS, dropping dramatically in regions of intense star formation, where the UV radiation from newly formed stars dissociates the H2 molecule, illustrating the self-regulating nature of the star formation process.
An EAGLE’s view of ex situ galaxy growth
Authors: Davison Thomas A , Norris Mark A , Pfeffer Joel L , Davies Jonathan J , Crain Robert A 
Published: June 2020

ABSTRACT
Modern observational and analytical techniques now enable the direct measurement of star formation histories and the inference of galaxy assembly histories. However, current theoretical predictions of assembly are not ideally suited for direct comparison with such observational data. We therefore extend the work of prior examinations of the contribution of ex situ stars to the stellar mass budget of simulated galaxies. Our predictions are specifically tailored for direct testing with a new generation of observational techniques by calculating ex situ fractions as functions of galaxy mass and morphological type, for a range of surface brightnesses. These enable comparison with results from large field of view (FoV) Integral Field Unit (IFU) spectrographs, and increasingly accurate spectral fitting, providing a look-up method for the estimated accreted fraction. We furthermore provide predictions of ex situ mass fractions as functions of galaxy mass, galactocentric radius, and environment. Using z = 0 snapshots from the 100 and 25 cMpc3 EAGLE (Evolution and Assembly of GaLaxies and their Environments) simulations, we corroborate the findings of prior studies, finding that ex situ fraction increases with stellar mass for central and satellite galaxies in a stellar mass range of 2 × 107 to 1.9 × 1012 M⊙. For those galaxies of mass M* &gt; 5 × 108 M⊙, we find that the total ex situ mass fraction is greater for more extended galaxies at fixed mass. When categorizing satellite galaxies by their parent group/cluster halo mass, we find that the ex situ fraction decreases with increasing parent halo mass at fixed galaxy mass. This apparently counterintuitive result may be due to high passing velocities within large cluster haloes inhibiting efficient accretion on to individual galaxies.
The compact triply eclipsing triple star TIC 209409435 discovered with TESS
Authors: Borkovits T , Rappaport S A , Tan T G , Gagliano R , Jacobs T , Huang X , Mitnyan T , Hambsch F-J , Kaye T , Maxted P F L , Pál A , Schmitt A R 
Published: June 2020

ABSTRACT
We report the discovery in TESS Sectors 3 and 4 of a compact triply eclipsing triple star system. TIC 209409435 is a previously unknown eclipsing binary with a period of 5.717 d, and the presence of a third star in an outer eccentric orbit of 121.872-d period was found from two sets of third-body eclipses and from eclipse timing variations. The latter exhibits signatures of strong third-body perturbations. After the discovery, we obtained follow-up ground-based photometric observations of several binary eclipses as well as another of the third-body eclipses. We carried out comprehensive analyses, including the simultaneous photodynamical modelling of TESS and ground-based light curves (including both archival WASP data, and our own follow-up measurements), as well as eclipse timing variation curves. Also, we have included in the simultaneous fits multiple star spectral energy distribution data and theoretical PARSEC stellar isochrones. We find that the inner binary consists of near twin stars of mass 0.90 M⊙ and radius 0.88 R⊙. The third star is just 9 per cent more massive and 18 per cent larger in radius. The inner binary has a rather small eccentricity, while the outer orbit has e = 0.40. The inner binary and outer orbit have inclination angles within 0.1° and 0.2° of 90°, respectively. The mutual inclination angle is ≲1/4°. All of these results were obtained without radial velocity observations.
Perinatal exposure to high dietary advanced glycation end products affects the reproductive system in female offspring in mice
Authors: Merhi Zaher , Du Xiu Quan , Charron Maureen J 
Published: June 2020

AbstractMaternal nutrition and the intrauterine environment are important in determining susceptibility to reproductive and metabolic disturbances. Advanced glycation end products (AGEs) are widely consumed in Western diet. The purpose of this study was to determine whether perinatal exposure to a high levels of dietary AGEs affect metabolic and reproductive parameters in female mice offspring. Female CD1 mice, 7 weeks old, were placed on either a diet low (L-AGE) or high (H-AGE) in AGEs before mating and then during pregnancy and lactation. All offspring were weaned onto the L-AGE diet and studied through to 16 weeks of age; they were counted and weighed at birth and then every week for a total of 11 weeks. Vaginal opening, litter size, growth curve, liver and abdominal fat weights, serum levels of anti-Mullerian hormone, leptin and adiponectin, as well as insulin and glucose tolerance tests were compared. Ovaries were harvested for follicular count and gene expression by real-time polymerase chain reaction. Compared to perinatal exposure to the L-AGE diet, perinatal exposure to the H-AGE diet caused lower body weight at birth, and adult offspring exhibited delayed growth, lower serum leptin and adiponectin levels, delayed vaginal opening, irregular oestrous cyclicity, arrested follicular development and significant alterations in the expression of genes involved in folliculogenesis (Amh and Amhr2) and steroidogenesis (Cyp19a1). These results indicate that perinatal exposure to a diet elevated in AGEs causes deficits in perinatal growth, pubertal onset, and reproductive organ development in female mice. Whether these findings translate to humans remains to be determined in future studies.
The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27
Authors: Lemus-Diaz Nicolas , Ferreira Rafael Rinaldi , Bohnsack Katherine E , Gruber Jens , Bohnsack Markus T 
Published: June 2020

Abstract
MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA biogenesis pathway involving stepwise processing and export of pri- and pre-miRNA transcripts by the microprocessor complex, Exportin 5 and Dicer, several alternative mechanisms of miRNA production have been described. Here, we reveal that the atypical box C/D snoRNA U3, which functions as a scaffold during early ribosome assembly, is a miRNA source. We show that a unique stem–loop structure in the 5′ domain of U3 is processed to form short RNA fragments that associate with Argonaute. miR-U3 production is independent of Drosha, and an increased amount of U3 in the cytoplasm in the absence of Dicer suggests that a portion of the full length snoRNA is exported to the cytoplasm where it is efficiently processed into miRNAs. Using reporter assays, we demonstrate that miR-U3 can act as a low proficiency miRNA in vivo and our data support the 3′ UTR of the sortin nexin SNX27 mRNA as an endogenous U3-derived miRNA target. We further reveal that perturbation of U3 snoRNP assembly induces miR-U3 production, highlighting potential cross-regulation of target mRNA expression and ribosome production.
Pain Status as a Predictor of Smoking Cessation Initiation, Lapse, and Relapse
Authors: Ditre Joseph W , Heckman Bryan W , LaRowe Lisa R , Powers Jessica M 
Published: June 2020

Abstract

Introduction
Pain and cigarette smoking are highly prevalent and frequently co-occurring conditions that interact in the manner of a positive feedback loop. Despite initial evidence that smokers with co-occurring pain may experience greater difficulty quitting, we are unaware of previous research that has tested prospective associations between pain status and the attainment of smoking cessation milestones.

Aims and Methods
This study examined past 2-week pain status as a predictor of cessation milestones among current smokers who were motivated to quit (Sample 1; N = 301) and smokers who recently initiated a cessation attempt (Sample 2; N = 242). Cessation milestones included initiation of a quit attempt and 7-day point prevalence abstinence (PPA; Sample 1), lapse/relapse (Sample 2), and 7-day PPA at 2-month follow-up (both samples). Indirect associations between pain status and cessation milestones via confidence in quitting and nicotine withdrawal were also examined.

Results
Smokers with pain (vs. no pain) were as follows: less likely to initiate a quit attempt and achieve 7-day PPA; more likely to lapse and/or relapse; and less likely to report 7-day PPA at follow-up. Pain status was indirectly associated with latency cessation milestones via confidence in quitting and with latency to lapse via withdrawal severity.

Conclusions
This study demonstrated that pain status can predict smoking cessation outcomes. Clinical implications include the need to assess pain in the context of quitting and that smokers with co-occurring pain may benefit from tailored/integrated cessation interventions.

Implications
A growing empirical literature indicates that the presence of co-occurring pain probably contributes to the maintenance of cigarette dependence. The current results provide novel evidence that smokers with co-occurring past 2-week pain are less likely to initiate a quit attempt and maintain smoking abstinence than smokers without co-occurring pain. These findings suggest that smokers with pain face unique barriers to quitting and underscore the utility of assessing and addressing pain among all smokers who are planning a smoking cessation attempt.
Quantification of Flavorants and Nicotine in Waterpipe Tobacco and Mainstream Smoke and Comparison to E-cigarette Aerosol
Authors: Erythropel Hanno C , Garcia Torres Deyri S , Woodrow Jackson G , de Winter Tamara M , Falinski Mark M , Anastas Paul T , O’Malley Stephanie S , Krishnan-Sarin Suchitra , Zimmerman Julie B 
Published: June 2020

Abstract

Introduction
Waterpipe use remains popular among youth with the availability of flavored shisha tobacco being one of the main drivers of waterpipe use. Although waterpipe mainstream toxicant emissions are well understood, less is known about the carryover of flavorants such as vanillin, benzaldehyde, and eugenol. In this study, flavored waterpipe tobacco was analyzed for flavorants and nicotine, and subsequent carryover to mainstream smoke.

Methods
Flavorants vanillin, benzaldehyde, and eugenol, and nicotine were quantified in vanilla-, cherry-, and cinnamon-flavored shisha tobacco by gas chromatography/flame ionization detector and subsequently in waterpipe mainstream smoke generated by a smoking machine. The setup allowed for sampling before and after the water-filtration step.

Results
Flavorant and nicotine content in smoke was reduced 3- to 10-fold and 1.4- to 3.1-fold, respectively, due to water filtration. Per-puff content of filtered waterpipe mainstream smoke ranged from 13 to 46 µg/puff for nicotine and from 6 to 55 µg/puff for flavorants.

Conclusions
Although water filtration reduced flavor and nicotine content in waterpipe mainstream smoke, the detected flavorant concentrations were similar or higher to those previously reported in e-cigarette aerosol. Therefore, users could be drawn to waterpipes due to similar flavor appeal as popular e-cigarette products. Absolute nicotine content of waterpipe smoke was lower than in e-cigarette aerosol, but the differential use patterns of waterpipe (&gt;100 puffs/session) and e-cigarette (mostly &lt;10 puffs/session, multiple session throughout the day) probably result in higher flavorant and nicotine exposure during a waterpipe session. Strategies to reduce youth introduction and exposure to nicotine via waterpipe use may consider similar flavor restrictions as those for e-cigarettes.

Implications
Although waterpipe mainstream smoke is well characterized for toxicants content, little is known about carryover of molecules relevant for appeal and addiction: flavorants and nicotine. This study shows that flavorant content of waterpipe mainstream smoke is comparable or higher than e-cigarette aerosol flavorant content. Regulatory action to address tobacco use behaviors targeting the availability of flavors should also include other tobacco products such as flavored shisha tobacco.
ENDS Device Type and Initiation of Combustible Tobacco Products Among Adolescents
Authors: Sumbe Aslesha , Clendennen Stephanie L , Opara Samuel C , Jackson Christian D , Chen Baojiang , Wilkinson Anna V , Harrell Melissa B 
Published: June 2020

Abstract

Introduction
The aim of this study was to determine whether Electronic Nicotine Delivery Systems (ENDS) device type (disposable devices, replaceable cartridges, and refillables) at initial or first ENDS use predicts subsequent initiation of combustible tobacco products (cigarettes, hookah, cigars) among adolescents and/or differentiates between those who initiate use of both ENDS and combustible tobacco products at the same time.

Methods
The study examined data from the Texas Adolescent Tobacco and Marketing Surveillance System (TATAMS), a longitudinal population-based cohort of students in major metropolitan areas of Texas (n = 3907; N = 461 069). Data were collected every 6 months, from 2014 to 2018; 33.9% (n = 1324; N = 151 784) of the sample initiated ENDS use across this period. Unadjusted and adjusted logistic regression models were used to assess the odds of initiating combustible tobacco products at a subsequent or similar wave as ENDS initiation, given initial ENDS device type.

Results
After adjusting for sociodemographic factors, the odds of initiating combustible tobacco use subsequent to ENDS initiation were significantly lower among those who reported using Cartridges as their initial device type compared to those who reported Refillables as their initial device type (adjusted odds ratio = 0.42 [0.18–0.98], p = .05). In addition, after controlling for sociodemographic variables, the odds of initiating combustible tobacco use in the same wave as ENDS initiation were significantly higher among those who reported using Cartridges as their initial device type, compared with those who reported Refillables as their initial device type (adjusted odds ratio = 2.31 [1.05–5.10], p = .04). No significant differences were found in adjusted models when Disposables were compared to Refillables and Cartridges to Disposables.

Conclusion
ENDS device type differentiates between adolescents who start using combustible tobacco products at the same time as initial ENDS use, or subsequently.

Implications
Previous research has shown ENDS use predicts subsequent combustible use among adolescents, but there is lack of research on the role of specific ENDS device types and the timing of initiation. Findings from this longitudinal study show that initiation of combustible tobacco product use varies by initial ENDS device type among adolescents. These findings can become a focal point for developing interventions for adolescents and could have regulatory implications for ENDS products.
Enhanced $\Gamma(p\to K^0\mu^+)/\Gamma(p\to K^+\bar{\nu}_\mu)$ as a signature of minimal renormalizable SUSY SO (10) GUT
Authors: Haba Naoyuki , Mimura Yukihiro , Yamada Toshifumi 
Published: June 2020

Abstract
The ratio of the partial widths of some dimension-5 proton decay modes can be predicted without detailed knowledge of supersymmetric (SUSY) particle masses, and this allows us to experimentally test various SUSY grand unified theory (GUT) models without discovering SUSY particles. In this paper, we study the ratio of the partial widths of the $p\to K^0\mu^+$ and $p\to K^+\bar{\nu}_\mu$ decays in the minimal renormalizable SUSY $SO(10)$ GUT, under only a plausible assumption that the 1st- and 2nd-generation left-handed squarks are mass-degenerate. In the model, we expect that the Wilson coefficients of dimension-5 operators responsible for these modes are on the same order and that the ratio of $p\to K^0\mu^+$ and $p\to K^+\bar{\nu}_\mu$ partial widths is $O(0.1)$. Hence, we may be able to detect both $p\to K^0\mu^+$ and $p\to K^+\bar{\nu}_\mu$ decays at Hyper-Kamiokande, thereby gaining a hint for the minimal renormalizable SUSY $SO(10)$ GUT. Moreover, since this partial width ratio is quite suppressed in the minimal $SU(5)$ GUT, it allows us to distinguish the minimal renormalizable SUSY $SO(10)$ GUT from the minimal $SU(5)$ GUT. In the main body of the paper, we perform a fitting of the quark and lepton masses and flavor mixings with the Yukawa couplings of the minimal renormalizable $SO(10)$ GUT, and derive a concrete prediction for the partial width ratio based on the fitting results. We find that the partial width ratio generally varies in the range $0.05$–$0.6$, confirming the above expectation.
Training cosmetology students in Arkansas to help dermatologists find skin cancers earlier: results of a cluster-randomized controlled trial
Authors: Fischbach Lori , Faramawi Mohammed F , Girard Deborah , Thapa Susan , Travers Robin 
Published: June 2020

Abstract

Background
We tested an educational video in cosmetology schools to increase students’ knowledge about skin cancer, sun-safety practices, identifying suspicious lesions and recommending clients consult a dermatologist when a suspicious lesion is observed.

Methods
We used a cluster-randomized controlled study design to randomize 22 cosmetology schools to receive our educational video or a publicly accessible healthy lifestyle video (control).

Results
Students who received the intervention were more likely than controls to increase their knowledge of skin cancer, risk factors and how to identify potential skin cancers (risk ratio [RR] and 95% confidence interval = 2.86 [1.58–5.20]). At follow-up, students in the intervention group were more likely than those in the control group to look for suspicious moles on their clients’ faces, scalps and necks (RRs = 1.75, 2.16 and 2.90, respectively). Additionally, students in the intervention group were more likely to communicate with clients about sun-safety practices (RR = 1.74 [1.11–2.73]) and consulting a dermatologist about suspicious moles (RR = 1.57 [1.03–2.41]).

Conclusions
Our educational video helped cosmetology students recognize potential skin cancers and talk with clients about sun safety and consulting a dermatologist about suspicious moles. Such videos may play a role in the public health surveillance of skin cancers in communities.
The incidence rate of pulmonary arterial hypertension and scleroderma renal crisis in systemic sclerosis patients with digital ulcers on endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i)
Authors: Pestaña-Fernández Melani , Rubio-Rivas Manuel , Tolosa-Vilella Carles , Guillén-Del-Castillo Alfredo , Colunga-Argüelles Dolores , Argibay Ana , Marí-Alfonso Begoña , Marín-Ballvé Adela , Pla-Salas Xavier , Chamorro Antonio-J , Castro-Salomó Antoni , Madroñero-Vuelta Ana Belén , Sánchez-García María Esther , Sáez-Comet Luis , González-Echávarri Cristina , Ortego-Centeno Norberto , Vargas-Hitos José Antonio , Todolí-Parra José Antonio , Trapiella-Martínez Luis , Lledó Gema María , Freire Mayka , Fonollosa-Pla Vicent , Simeón-Aznar Carmen Pilar ,   for RESCLE Investigators, Autoimmune Diseases Study Group (GEAS)
Published: June 2020

Abstract

Introduction
Endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i) are beneficial in pulmonary arterial hypertension (PAH) and digital ulcers (DU) and prevent from DU recurrences. Our study aimed to determine the difference in the incidence rate of PAH and scleroderma renal crisis (SRC) in patients with SSc and DU (SSc-DU) under ERAs/PDE5i or without treatment.

Methods
We conducted a retrospective cohort study including SSc-DU patients from the Spanish Scleroderma Registry (RESCLE). The primary outcome was the incidence rate of PAH and SRC in patients under ERAs/PDE5i or not.

Results
Some 544 patients out of 1817 (29.9%) in the RESCLE database had DU, 221 (40.6%) under ERAs/PDE5i and 323 (59.4%) not. The incidence rate (95% CI) difference between patients under treatment or not under did not reach statistical significance in PAH [−0.1 (−4.8, 4.69), P = 0.988] or in SRC [0.7 (−2.2, 3.7), P = 0.620]. However, the time from the first DU to the diagnosis of SRC was delayed in treated patients [mean (s.d.) 7.6 (5.8) years vs 2.9  (5.3); P = 0.021]. The dcSSc subset was more prevalent in the treatment group (36 vs 26%; P = 0.018), along with anti-topoisomerase I antibodies (34 vs 18%; P &lt; 0.001) and tendon friction rubs (12 vs 6%; P = 0.038), whereas the lcSSc subset was more prevalent in the no-treatment group (57 vs 66%; P = 0.031) along with ACA (37 vs 46%; P = 0.031).

Conclusion
There was no difference in the incidence rate of PAH and SRC between groups. However, treatment with ERAs and/or PDE5i appeared to delay the occurrence of SRC.