bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applicability of American College of Clinical Pharmacy (ACCP) competencies to clinical pharmacy practice in Egypt
Authors: Elmaaty Mahmoud A. , Elberry Ahmed A. , Hussein Raghda R. , Khalil Doaa M. , Khalifa Amani E. 
Published: September 2020

Background: The American College of Clinical Pharmacy (ACCP) prepared clinical pharmacist competencies that have specific recommendations. Recently, many efforts to advance clinical pharmacy services in Egypt exist. The literature revealed that no country has assessed the extent of applicability of ACCP competencies in its current pharmacy practice setting. Egyptian pharmacists can provide feedback about applicability of such competencies in clinical pharmacy settings in Egypt.
Objective: The objective of this study was to investigate the extent to which ACCP competencies were implemented by Egyptian clinical pharmacists and therefore evaluate development of clinical pharmacy practice in Egypt. The study also investigated factors affecting the applicability of such competencies in the current clinical pharmacy practice setting in Egypt.
Methods: Four hundred and ninety-five randomly selected clinical pharmacists from several hospitals were invited to participate in a cross sectional survey using a self-administered validated questionnaire composed of 31 questions classified into six domains. This questionnaire was designed to determine the pharmacists’ perception about applicability of ACCP competencies to clinical pharmacy practice in Egypt.
Results: The response rate was 64% as 317 out of 495 pharmacists completed the questionnaire. These pharmacists were categorized according to age; gender; qualifications; years of previous work experience, years since BSc. and type of hospitals they are currently working at. Analysis of data revealed the professionalism domain to have the highest percentage of acceptance among pharmacists, while the system-based care & population health domain had the lowest percentage of acceptance. Results also showed that qualifications of participants did not affect their response in three domains; “Direct Patient Care”, “Systems-based Care & Population Health” and “Continuing Professional Development” (p=0.082, 0.081, 0.060), respectively. Nevertheless, qualifications of participants did affect their response in the other three domains; “Pharmacotherapy Knowledge”, “Communication” and “Professionalism” (p<0.05). The age of pharmacists, gender, years of previous work experience, and graduation year did not affect their responses in all six domains. The type of hospital they are currently working at, though, affected their responses where, there was a highly statistically significant increase of the mean score of all domains among participants working at the NGOs/private hospitals compared to governmental hospitals (p<0.001).
Conclusions: Egyptian pharmacists generally apply high percentage of ACCP competencies but the provided clinical pharmacy services need to be improved through applying the standards of best practice.
Monocyte to high-density lipoprotein ratio and high sensitive c-reactive protein levels in patients with isolated coronary artery ectasia
Authors: KILIÇ Alparslan , BAYDAR Onur 
Published: September 2020

Aim: Isolated coronary artery ectasia (ICAE) is a rare form of coronary artery disease and has almost same mortality and morbidity rate to atherosclerotic coronary artery disease. Monocyte to HDL-cholesterol ratio (MHR) has been entered the literature as a new inflammatory indicator in various cardiovascular disease. In this study we want to investigate relationship between inflammatory and oxidative markers that high sensitive C reactive protein (Hs-Crp), MHR and ICAE.
Material and Methods: We retrospectively observed patients who underwent elective coronary angiography. Patients with ICAE and normal coronary arteries included in the study. MHR and Hs-Crp levels were observed just before the coronary angiography procedure.
Results: A total of 98 patients (61, 62 % men) patients were included in this study and 28 (28.6%) of them had DM. 68 (69.3%) of patients had ICAE. MHR was significantly higher in patients with ICAE (0.0153 (0.007-0.130)ve 0.0111 (0.005-0.020), p< 0.001). Hs-Crp was also significantly higher in patients with ICAE (Yd-Crp: 6 (0.2-33)ve 1(0.2-14), p < 0.001). MHR was also significantly correlated with Hs-crp levels (r:0,338, p: 0.001). Additionally; DM, smoking, HT, MHR and Hs-crp were detected as independent risk factors of ICAE in logistic regression analysis. In receiver operating characteristic curve analysis, the area under the curve for predicting CAE was 0.744 (p
Alopesi areata ile serum 25(OH) d vitamini ilişkisi
Authors: TERZİ Erdinç 
Published: September 2020

Amaç:Alopesi areata(AA) hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile AA arasında olası bir ilişki olup olmadığı belirlemektir.
Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında AA tanısı konulan 43 hasta ve 69 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi.Ayrıca serum kalsiyum, fosfor, alkalen fosfataz ve paratiroid hormon seviyeleri de değerlendirildi.
Bulgular: Çalışmamıza 10-47 yaş(ortalama: 33.41 ± 7.2) arasındaki 43 hasta ve kontrol grubunda 18-55 yaş arası(ortalama: 33,53 ± 7.2). 69 sağlıklı birey katılmıştır. AA'lı hastalarda serum 25 (OH) D seviyeleri ortalama 20,21 ng / ml (3,7-43,5 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 24,09 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05).
Sonuç: Bu sonuçlar ışığında AA ile serum 25(OH) D vitamini arasında herhangi bir ilişki saptanmamıştır.
N-acetyl cysteine attenuates ferroptosis mediated lung injury induced by lower limb ischaemia/reperfusion
Authors: TÜMER Naim Boran 
Published: September 2020

Aim: This study aimed to analyze the effect of N-acetyl cysteine pretreatment on the prevention of ferroptosis mediated lung injury induced by lower limb ischemia and reperfusion.
Material and Methods: Eighteen male Sprague-Dawley rats weighing 350-400 g were randomized into three groups. The animals received N-acetyl cysteine 150 mg/kg or normal saline 0.1 ml/kg intraperitoneally before the ischemic period. In the control and study groups, I/R injury was induced by clamping the aorta infrarenal for 2 hours, followed by 4 hours of reperfusion. The third group underwent sham surgery. After sacrifice, the lungs of the animals were extracted for both histopathological and biochemical analysis.
Results: There was a significant difference between the control and study animals regarding tissue malondialdehyde (MDA), and glutathione (GSH) levels. In the control group, the MDA levels were increased and the GSH levels were increased significantly compared to the sham group that revealed a ferroptosis mediated lung injury. However, N-acetyl cysteine decreased the levels of MDA and increased the levels of GSH revealing a protective effect. The Prussian blue (free iron stain) staining which was used to examine iron deposition revealed a reduced deposition of iron in the N-acetyl cysteine group.
Conclusion: The results of the present study suggest a protective effect of N-acetyl cysteine on ferroptosis mediated lung injury induced by lower limb ischemia-reperfusion in a rat model.
Effects of single high dose topical tranexamic acid administration on bleeding and complicatıons after total knee arthroplasty surgery:A retrospective clinical study
Authors: ŞİMSEK Ekin Kaya , HABERAL Bahtiyar 
Published: September 2020

Aim: There is no consensus on the optimal method of Tranexamic acid (TA) usage in orthopaedic surgery in the literature. The aim of this study is to evaluate the effects of single high dose (3g) topical TA application on postoperative bleeding and complications in total knee arthroplasty (TKA) surgery.
Material and Methods: We retrospectively evaluated patients who underwent TKA in our clinic between January 2016 and June 2018. The patients were divided into two groups according to TA administration: Group 1 (topical TA, n=105/242) and Group 2 (non-TA, n=137/242). Demographic parameters, comorbidities, high-risk factors, preoperative hemoglobin (Hb) level, lowest postoperative Hb level, change in Hb, total drainage output, presence or absence of a transfusion, amount of blood transfused, length of stay, and complications were evaluated.

Results:In group 1, postoperative first- and second-day Hb levels were significantly higher than those in group 2. The blood loss on the day of surgery, the blood loss on the first postoperative day and total drain blood loss were significantly lower in group 1. It was determined that the patients in group 2 needed significantly more blood transfusions and had more length of hospital stay. There was no statistical difference in complications between the two groups.
Conclusion:Topical TA application effectively and significantly reduces blood loss and transfusion rates after surgery, without serious side effects, in patients undergoing primary TKA. This also reduces the length of the hospital stay.
Supraglottik Havayolu Gereçleri Kullanılan Çocuklarda Perioperatif Havayolu Kalitesi
Authors: KOTANOĞLU Mustafa Sırrı , BALTACI Bülent , BEKTAŞ Meltem , ÇAKIRCA Mehmet , NAKİP Mert , VARLI Muhiddin , BAŞAR Hülya 
Published: September 2020

Amaç:
Supraglottik havayolu araçları havayolunun kontrolü ve mekanik ventilasyon için yaygın olarak kullanılmaktadır. Bu çalışmada 1 saatten kısa süreli pediatrik cerrahi olgularında 2 farklı supraglottik havayolu aygıtının (Klasik LMA, İ-gel LMA) yerleştirme koşulları ve ventilasyondaki etkinliğinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem:
Ankara Eğitim ve Araştırma Hastanesi Eğitim Planlama Koordinasyon Kurulu onayı alındıktan sonra, Klasik LMA ve İ-gel LMA yerleştirilecek 2-7 yaş arası ASA I-II grubu 60 pediatrik olgu, ailelerinden onam alınarak çalışmaya dahil edilmiştir. Anestezi indüksiyonu 2,5 mgkgˉ¹ propofol, 1mcgkgˉ¹ fentanyl, 1 mgkgˉ¹ lidokain ve 0,2 mgkgˉ¹ rocuronyum uygulanmıştır. Anestezi idamesinde 2ltdkˉ¹ %50 N2O – O2 karışımı %2 Sevofluran ile sağlanmıştır. Klasik LMA uygulanan olgular grup K-LMA (n=30), İ-gel LMA uygulanan olgular ise Grup İ-gel (n=30) dahil edilmiştir. Olguların demografik verileri, kullanılan LMA tipi, LMA boyutu, LMA’nın kaçıncı denemede yerleştirildiği, LMA yerleştirme süresi, LMA kaçak basıncı kaydedilmiştir. Uygulayıcı tarafından LMA’nın yerleştirme kolaylığı 3 puan üzerinden (1: Çok kolay, 2: Kolay 3: Zor) değerlendirilmiştir. Vokal kordların görünümü ise Fiberoptik Bronkoskop (FOB) ile kontrol edilerek 4 puan üzerinden değerlendirilmiştir. İstatistiksel analiz için SPSS paket veri 23 programı kullanılmıştır.
Bulgular:
Grupların demografik verilerinde istatistiksel olarak anlamlı fark bulunamamıştır. LMA deneme sayısı, yerleştirme süresi, uygulama kolaylığı, kaçak basıncı ve FOB ile glottik görünüm için istatistiksel olarak anlamlı fark bulunamamıştır. İlk denemede yerleştirme için gruplar arasında anlamlı fark bulunamamıştır.

Sonuç:
Bu çalışmada 2-7 yaş arası pediatrik olgularda Klasik LMA ile İ-gel LMA’nın aynı etkinlikte kullanılabildiği sonucuna ulaşılmıştır. Fiberoptik görünümde İ-gel LMA’nın Klasik LMA’ya üstünlüğü saptanamamıştır.
PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomları patoloji sonucunu ön görebilir mi?
Authors: BAŞER Aykut , AYDIN Cemil , ÇELİKÖRS Bilal , YILMAZ BAŞER Hülya , BAYKAM Mehmet Murat , ALKIŞ Okan 
Published: September 2020

Amaç: Bu çalışmada PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomalarının prostat adenokanser ve benign prostat hiperplazisini ön görecek bir parametre olup olmadığını araştırmayı amaçladık.
Gereç ve Yöntemler: 01 Haziran 2019 - 01 Şubat 2020 tarihleri arasında PSA değeri 4-10 ng/ml olan ilk kez TRUS-Bx uygulanan 75 hasta prospektif olarak çalışmaya dahil edildi. Hastaların yaş, BMI, PSA, Prostat hacmi, PSA dansitesi, uluslararası prostat semptom skorları ve uluslararası erektil fonksiyon skorları kayıt edildi. Patoloji sonucuna göre grup 1 (benign prostat hiperplazisi) ve grup 2 (prostat adenokanser) olarak hastalar 2 gruba ayrılarak belirtilen parametreler ile ilişkisi araştırıldı.
Bulgular: PSA değeri 4-10 ng/ml olan ilk kez TRUS-Bx uygulanan 75 hastanın patoloji sonucunda; 57 (%76) hastada Benign Prostat Hiperplazisi (BPH) (grup 1), 18 (%24) hastada Prostat Adenokanser (PCa) (grup 2) saptandı. İncelenen parametrelerden sadece rektal tuşe de sertlik bulgusu (p=0.001) ve IPSS skor düşüklüğü (p=0.022) Grup 2’de grup 1’e göre istatistiksel anlamlı farklılık saptandı. Yapılan korelasyon analizinde de bulgular teyit edildi.
Sonuç: PSA 4-10 ng/mL olan hastalar için IPSS skor düşüklüğü, rektal tuşe de sertlik olması kanser saptanma ihtimalini arttırmaktadır.
Analysis Metallothionein of Carp fish in The Brantas River, Indonesia
Authors: Setiyowati Putri Ayu Ika , Solekha Rofiatun , Sahara Sri Bintang , Hapsari Febianti Dwi 
Published: September 2020

This study aimed to detection of protein profile, expression of metalothionein (MT) protein, and analyze difference of MT density in liver and gill in one of Carp fish that is Barbonymus balleroides in the upstream and downstream of Brantas river. The method used observasional analytic, Two individual of Barbonymus balleroides samples taken three times (with difference of month) from two station there are upstream and downstream of Brantas river. Analysis protein profile used electrophoresis SDS-PAGE (15%), expression and density of MT used western blot method and imageJ software. Difference between MT density in liver and gill of Barbonymus balleroides in the upstream and downstream of Brantas river analyzed with Two-way ANOVA. The results showed, protein profile in liver and gill Barbonymus balleroides in the upstream and downstream Brantas river have molecular weight about 8-93 kDa, expression of MT showed band of MT with molecular weight 24 kDa, results of MT density in liver and gill on upstream and downstream, continuously 231.29 MT/µm2 and 229.87MT/µm2, 232.41 MT/µm2 and 231.56 MT/µm2 but there is not significant.
THE EFFECTS OF MODEL PROJECT-BASED LEARNING APPROACH ON STEM (SCIENCE, TECHNOLOGY, ENGINEERING, MATHEMATIC) ON SCIENCE LEARNING TO JUNIOR HIGH SCHOOL STUDENT’S CRITICAL THINKING SKILLS AND COOPERATIVE SKILLS
Authors: Indriyana Riyani Septi , Susilowati Susilowati 
Published: September 2020

The research aimed to (1) analyzes the effects of model project-based learning approach on STEM (science, technology, engineering, mathematic) on science learning to junior high school student’s critical thinking skills and cooperative skills, and (2) analyze how the effects of model project-based learning approach on STEM (science, technology, engineering, mathematic) on science learning to junior high school student’s critical thinking skills and cooperative skills. The research was quasi-experimental with a non-equivalent control group design. The population was eighth-grade students of SMP Negeri 1 Berbah. The sample of the study was selected with cluster random sampling techniques and obtained grade-VIII B as an experimental class and grade-VIII C as a control class. Learning in the experimental class with a project-based learning model was STEM-oriented and the control class used a scientific approach. The data were pretest and posttest of critical thinking and observation sheets of cooperation. The analysis used the normality test, homogeneity test, MANOVA test, and effect size. The results showed that (1) there was an effect of project based learning model on STEM approach on critical thinking skills and cooperative skills of students of SMP Negeri 1 Berbah, (2) the effect of science learning project based learning model on STEM approach on critical thinking and collaborative skill was on medium category.
Analisis kesalahan siswa dalam menyelesaikan soal cerita matematika berdasarkan kriteria Watson
Authors: Mafruhah Laely , Muchyidin Arif 
Published: September 2020

Tujuan dari penelitian ini adalah untuk mendeskripsikan kesalahan yang dilakukan oleh siswa dalam menyelesaikan soal cerita matematika berdasarkan kriteria Watson dan faktor-faktor yang menyebabkan siswa melakukan kesalahan tersebut. Penelitian ini merupakan penelitian deskriptif kualitatif dengan melibatkan 44 siswa kelas VII MTs Yapik Sindangjawa, Cirebon sebagai subjek penelitian. Data jenis kesalahan dan faktor yang menyebabkan siswa melakukan kesalahan dalam menyelesaikan soal cerita matematika diperoleh melalui tes penyelesaian masalah berbentuk soal cerita matematika dan pedoman wawancara. Hasil penelitian menunjukkan bahwa subjek dalam penelitian ini melakukan kesalahan yang bervariasi dari delapan jenis kesalahan yang ada pada kriteria Watson. Jenis kesalahan yang sering dilakukan oleh siswa adalah Inappropriate Procedure (IP) yaitu prosedur yang digunakan tidak tepat, Omitted Conclusion (OC) yaitu tidak menuliskan kesimpulan, dan Above Other (AO) yaitu kesalahan lainnya seperti tidak mengerjakan soal. Adapun jenis kesalahan yang jarang dilakukan oleh siswa adalah Response Level Conflict (RLC) yaitu siswa berusaha menyelesaikan soal, namun menghasilkan kesimpulan yang kurang logis. Beberapa faktor penyebab siswa melakukan kesalahan dalam menyelesaikan soal cerita matematika adalah siswa tidak mengetahui rumus yang akan digunakan, kurangnya waktu dalam mengerjakan semua soal tes, dan siswa menganggap bahwa soal cerita merupakan soal yang sulit untuk diselesaikan. Analysis of students' errors in solving mathematical word problems based on Watson's criteriaAbstractThis study aimed to describe the errors made by students in solving mathematical word problems according to Watson’s criteria as well as factors that cause students to do that errors. This study was a qualitative descriptive study involved 44 seventh graders of MTs Yapik Sindangjawa, Cirebon, Indonesia as the subjects of this study. Data of error types and factors that lead students to do such errors in solving mathematical word problems were collected using the test of solving mathematical word problems and interview guidelines. The results showed that the subjects made various errors from the eight types of errors that exist in Watson's criteria. The types of errors that often made by students were Inappropriate Procedure (IP) namely using inappropriate procedures; Omitted Conclusion (OC) namely students not writing conclusions; and Above Other (AO) namely making other mistakes such as not giving a response towards the given problem. The type of error that was rarely made by students was Response Level Conflict (RLC), where students try to solve the problem but produce less logical conclusions. Some of the factors that cause students to do some errors in solving mathematical word problems namely students do not know the formula to be used to solve the given problems, lack of time to solve all problems of the test, and students think that the mathematical word problem was difficult to be solved.
Analisis situasi didaktis dalam pembelajaran matematika berbantuan ICT pada siswa SMP
Authors: Prabowo Ardhi , Juandi Dadang 
Published: September 2020

Penelitian ini bertujuan untuk mengidentifikasi apakah mahasiswa calon guru matematika mampu membangun situasi didaktis matematis pada siswa SMP dalam pembelajaran matematika berbasis ICT (Information and Communications Technology). Penelitian ini adalah penelitian deskriptif kualitatif. Subjek penelitian adalah mahasiswa calon guru yang telah praktik mengajar di sekolah. Subjek menggunakan aplikasi yang dibuat sendiri oleh subjek. Aplikasi yang dibuat berupa Augmented Reality (realitas bertumbuh), yaitu teknologi yang menggabungkan benda maya dua dimensi dan atau pun tiga dimensi ke dalam sebuah lingkungan nyata tiga dimensi lalu memproyeksikan benda-benda maya tersebut dalam waktu nyata. Hasil penelitian menunjukkan karakteristik situasi didaktis dalam pembelajaran matematika berbantuan ICT pada siswa SMP yang dibangun oleh mahasiswa calon guru adalah sebagai berikut: situasi didaktis matematis yang dibangun belum mengonstruksi pengetahuan siswa secara mandiri; situasi didaktis matematis yang dibangun cenderung berasal dari informasi yang disampaikan guru, bukan dari media ICT yang digunakan; dan ICT yang dilibatkan dalam pembelajaran belum mampu mengelaborasikan proses kognitif siswa dalam jejak pembelajarannya. Analysis of a didactic situation in ICT-assisted mathematics learning in junior high school studentsAbstractThis study aims to identify whether prospective mathematics teacher students are able to build mathematical didactic situations in junior high school students in ICT-based mathematics learning. This research is descriptive qualitative research. The research subjects were prospective teachers who had practiced teaching at school. The subjects used applications made by themselves. Those applications were in the form of augmented reality (reality grows), namely technology that combines two-dimensional and or three-dimensional virtual objects into a real three-dimensional environment and then projecting these virtual objects in real-time. The results showed the characteristics of didactic situations in ICT-assisted mathematics learning in junior high school students built by prospective teacher students were as follows: didactic mathematical situations that were built had not constructed students' knowledge independently; the built mathematical didactic situation tends to originate from the information conveyed by the teacher, not from the ICT media used; and ICT involved in learning has not been able to elaborate the cognitive processes of students in their learning footprint.
Studies on mosquito density in urban Kano: a study to calculate larval indices in municipal area of Gwale, Kano, Nigeria
Authors: Umar A.B. , Dankaka A.H. , Manjur Shah M. 
Published: September 2020

The study is carried out to standardize larval indices namely House Index, Container Index and Breteau Index and also to identify the major breeding sources of mosquitoes in the residential environment in and around the Gwale Local government area of Kano, Nigeria. A cross-sectional study by selecting 50 houses randomly from the 6 wards of Municipality was employed. Every water holding container indoors and outdoors were counted and searched for larval presence and noted on a pretested format. In this study, 300 houses were surveyed in 21 days out of which 94.33% (283 houses) were found to have potential sources for mosquito breeding. All the entomological indices were found to be above the critical level. House Index = 28.67%; Container Index = 12.14%; Breteau Index = 64.00% showing high chances for outbreaks of mosquito borne diseases. The area is prone to mosquito borne disease like malaria and therefore warrants interventions from the competent.
Critical length for the spreading-vanishing dichotomy in higher dimensions
Authors: Simpson Matthew J. 
Published: September 2020

We consider an extension of the classical Fisher–Kolmogorov equation, called the “Fisher–Stefan” model, which is a moving boundary problem on \(0<x<L(t)\) . A key property of the Fisher–Stefan model is the “spreading–vanishing dichotomy”, where solutions with \(L(t) > L_{\textrm{c}}\) will eventually spread as \(t \to \infty\) , whereas solutions where \(L(t) \ngtr L_{\textrm{c}}\) will vanish as \(t \to \infty\) . In one dimension it is well known that the critical length is \(L_{\textrm{c}} = \pi/2\) . In this work, we re-formulate the Fisher–Stefan model in higher dimensions and calculate \(L_{\textrm{c}}\) as a function of spatial dimensions in a radially symmetric coordinate system. Our results show how \(L_{\textrm{c}}\) depends upon the dimension of the problem, and numerical solutions of the governing partial differential equation are consistent with our calculations.
doi: 10.1017/S1446181120000103