bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atlantic Ocean Heat Transport Enabled by Indo‐Pacific Heat Uptake and Mixing
Authors: Holmes Ryan M. , Zika Jan D. , Ferrari Raffaele , Thompson Andrew F. , Newsom Emily R. , England Matthew H. 
Published: November 2019

AbstractThe ocean transports vast amounts of heat around the planet, helping to regulate regional climate. One important component of this heat transport is the movement of warm water from equatorial regions toward the poles, with colder water flowing in return. Here, we introduce a framework relating meridional heat transport to the diabatic processes of surface forcing and turbulent mixing that move heat across temperature classes. Applied to a (1/4)° global ocean model the framework highlights the role of the tropical Indo‐Pacific in the global ocean heat transport. A large fraction of the northward heat transport in the Atlantic is ultimately sourced from heat uptake in the eastern tropical Pacific. Turbulent mixing moves heat from the warm, shallow Indo‐Pacific circulation to the cold deeper‐reaching Atlantic circulation. Our results underscore a renewed focus on the tropical oceans and their role in global circulation pathways.
Intermittency in Wind‐Driven Surface Alteration on Mars Interpreted From Wind Streaks and Measurements by InSight
Authors: Day Mackenzie , Rebolledo Laura 
Published: November 2019

AbstractWind interacts with the surface of Mars to create the diverse landforms seen today. The morphology of wind streaks and related surface features has been used to interpret the winds on Mars in regions where actual wind measurement are lacking. Here we compare wind directions interpreted from bright wind streaks observed in orbitally‐acquired images with winds measured at the surface by the InSight lander in Elysium Planitia. The distribution of streak orientations is trimodal, dominantly reflecting winds from the southeast. The distribution of winds measured by InSight was highly variable with time of day but was dominantly characterized by winds from the northwest. The lack of coincidence between the two suggests that wind only intermittently deposits dust on the surface. The persistence of the streak orientations over five Mars years demonstrates that saltation in the region, if occurring, is not sustained long enough to rework these dust depositional surfaces.
Endocrine Complications of Cystic Fibrosis: A Multisystem Disease of the Endocrine Organs
Authors: Ode Katie Larson , Chan Christine L. , Granandos Andrea , Putman Melissa , Moheet Amir 
Published: November 2019

AbstractCystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans lengthen, increasing the impact of nonpulmonary complications. Our understanding of the management of these concerns continues to evolve, and, although there are some effective treatments, there is great opportunity for continued investigation into the pathophysiology of the endocrine complications of CF and their treatment.
Trituration Proving of Australian Acacias (WA)
Authors: Moore Sally 
Published: November 2019

AbstractTo date, a few Australian plants have been proven and used as homoeopathic remedies.We believe that the Australian native flora provides a yet untapped reservoir of healing potential.Four Australian Acacia species were used in the trituration: Acacias dentifera, pulchella, floribunda and longifolia.Potencies are available in the 3C, 4C and 5C range.
Implementation of the best practice guidelines on geriatric trauma care: a Canadian perspective
Authors: Bérubé Melanie , Pasquotti Theresa , Klassen Barbara , Brisson Angie , Tze Nancy , Moore Lynne 
Published: November 2019

Abstract

Background
traumatic injuries are increasingly affecting older patients who are prone to more complications and poorer recovery compared to younger patients. Practices of trauma health care providers therefore need to be adapted to meet the needs of geriatric trauma patients.

Objective
to assess the implementation of the American College of Surgeons best practice guidelines on geriatric trauma management across level I to III Canadian trauma centres.

Methods
69 decision-makers working in Canadian trauma centres were approached to complete a web-based practice survey. Percentages and means were calculated to describe the level of best practice guideline implementation.

Results
50 decision-makers completed the survey for a response rate of 72%. Specialised geriatric trauma resources were utilised in 37% of centres. Implementation of mechanisms to evaluate common geriatric issues (e.g. frailty, malnutrition and delirium) varied from 28 to 78% and protocols for the optimisation of geriatric care (e.g. Beers criteria to adjust medication, anticoagulant reversal and early mobilisation) from 8 to 56%. Guideline recommendations were more often implemented in level I and level II trauma centres. The adjustment of trauma team activation criteria to the geriatric population and transition of care protocols were more frequently used by level III centres.

Conclusion
despite the growing number of older patients admitted in Canadian trauma centres annually, the implementation of best practice guidelines on geriatric trauma management is still limited. Prospective multicentre studies are required to develop and evaluate interdisciplinary knowledge translation initiatives that will promote the uptake of guidelines by trauma centres.
Accuracy of computational pressure-fluid dynamics applied to coronary angiography to derive fractional flow reserve: FLASH FFR
Authors: Li Jianping , Gong Yanjun , Wang Weimin , Yang Qing , Liu Bin , Lu Yuan , Xu Yawei , Huo Yunlong , Yi Tieci , Liu Jian , Li Yongle , Xu Shaopeng , Zhao Lei , Ali Ziad A , Huo Yong 
Published: November 2019

AbstractAimsConventional fractional flow reserve (FFR) is measured invasively using a coronary guidewire equipped with a pressure sensor. A non-invasive derived FFR would eliminate risk of coronary injury, minimize technical limitations, and potentially increase adoption. We aimed to evaluate the diagnostic performance of a computational pressure-flow dynamics derived FFR (caFFR), applied to coronary angiography, compared to invasive FFR.Methods and resultsThe FLASH FFR study was a prospective, multicentre, single-arm study conducted at six centres in China. Eligible patients had native coronary artery target lesions with visually estimated diameter stenosis of 30–90% and diagnosis of stable or unstable angina pectoris. Using computational pressure-fluid dynamics, in conjunction with thrombolysis in myocardial infarction (TIMI) frame count, applied to coronary angiography, caFFR was measured online in real-time and compared blind to conventional invasive FFR by an independent core laboratory. The primary endpoint was the agreement between caFFR and FFR, with a pre-specified performance goal of 84%. Between June and December 2018, matched caFFR and FFR measurements were performed in 328 coronary arteries. Total operational time for caFFR was 4.54 ± 1.48 min. caFFR was highly correlated to FFR (R = 0.89, P = 0.76) with a mean bias of −0.002 ± 0.049 (95% limits of agreement −0.098 to 0.093). The diagnostic performance of caFFR vs. FFR was diagnostic accuracy 95.7%, sensitivity 90.4%, specificity 98.6%, positive predictive value 97.2%, negative predictive value 95.0%, and area under the receiver operating characteristic curve of 0.979.ConclusionsUsing wire-based FFR as the reference, caFFR has high accuracy, sensitivity, and specificity. caFFR could eliminate the need of a pressure wire, technical error and potentially increase adoption of physiological assessment of coronary artery stenosis severity.Clinical Trial RegistrationURL: http://www.chictr.org.cn Unique Identifier: ChiCTR1800019522.
Effects of Water Temperature Under Projected Climate Change on the Development and Survival of Enallagma civile (Odonata: Coenagrionidae)
Authors: Starr S M , McIntyre N E 
Published: November 2019

AbstractCurrent climate projections for the Great Plains of North America indicate markedly increased air temperatures by the end of the current century. Because the Great Plains contains &gt;80,000 intermittent wetlands that serve as irreplaceable wildlife habitat, this projected warming may have profound effects throughout a continental-scale trophic network. However, little research has been done to determine how projected warming may affect the growth, development, or survival of even common species in this region. We conducted laboratory warming experiments, using an abundant amphibious predatory insect, Enallagma civile (Hagen, 1861), as a model organism, to determine whether projected warming may affect development or survival. Eggs were collected and reared under four water temperature regimes representing current (26°C) and projected future conditions (32, 38, and 41°C). Nymph body size after each molt, development rate, and deaths were recorded. Elevated water temperatures were found to significantly affect the survivorship of E. civile eggs and nymphs as well as adult body size at emergence: an increase in temperature incurred a decrease in survival and size. Nymphs in the two hotter treatments were smaller and had low survivorship whereas individuals in the cooler temperatures generally survived to adulthood and were larger. Nymphs reared at 32°C experienced accelerated ontogenetic development compared with the other temperatures, going from egg to adult in 26 d. Projected elevated temperatures may, thus, be both advantageous and detrimental, causing concern for aquatic invertebrates in this region in the future.
Urban green space, tree canopy and prevention of cardiometabolic diseases: a multilevel longitudinal study of 46 786 Australians
Authors: Astell-Burt Thomas , Feng Xiaoqi 
Published: November 2019

Abstract

Background
Cross-sectional studies suggest that more green space may lower the odds of prevalent diabetes, hypertension and cardiovascular diseases (CVD) in cities. We assess if these results are replicable for tree canopy exposure and then extend the study longitudinally to examine incident cardiometabolic outcomes.

Methods
The study was set in the Australian cities of Sydney, Wollongong and Newcastle. Total green space and tree canopy as percentages of landcover within 1.6 km (1 mile) from home were linked to a residentially stable sample of 46 786 participants in the Sax Institute’s 45 and Up Study (baseline 2006–09; follow-up 2012–15). Separate multilevel models were used to investigate whether the odds of prevalent and incident doctor-diagnosed diabetes, hypertension and CVD were associated with total green space and tree canopy provision, adjusting for age, sex, income, education, employment and couple status.

Results
Lower odds of prevalent diabetes were observed with 1% increases in total green space [odds ratio (OR) 0.993, 95% confidence interval (CI) 0.988 to 0.998] and tree canopy (0.984, 0.978 to 0.989). Lower odds of prevalent CVD were found with a 1% increase in tree canopy only (0.996, 0.993 to 0.999). Lower odds of incident diabetes (0.988, 0.981 to 0.994), hypertension (0.993, 0.989 to 0.997) and CVD (0.993, 0.988 to 0.998) were associated with a 1% increase in tree canopy, but not total green space. At ≥30% compared with 0–9% tree canopy, there were lower odds of incident diabetes (0.687, 0.547 to 0.855), hypertension (0.828, 0.719 to 0.952) and CVD (0.782, 0.652 to 0.935). However, ≥30% compared with 0–4% total green space was associated with lower odds of prevalent diabetes only (0.695, 0.512 to 0.962).

Conclusions
Restoring local tree canopy in neighbourhoods may help to prevent the incidence of cardiometabolic diseases.
The effect of openings ratio and wall thickness on energy performance in educational buildings
Authors: Hashem Alqahtani Laila Amer , Eldeen Elgizawi Lamis Saad 
Published: November 2019

Abstract
The building envelope is the boundary between the outer and inner spaces and it is considered as the most significant part in the process of preservation of internal spaces cooling energy consumption. In this context, it is argued that the weakest point in the envelope with the highest transmittance of thermal energy into and out of the internal spaces is the openings (windows and doors) which are affected by many factors such as their ratio, material thermal properties and construction. Therefore, this study sheds light on the alternatives of the envelope design generated with the help of a computer-based simulation tool, Design-Builder, as it has great possibilities for creating simulated scenarios for a specific building or space by linking these scenarios with specific changes in the building parameters. Thus, the study will focus on creating different scenarios for a selected classroom in the College of Arts and Design at Princess Nourah bint Abdulrahman University (Riyadh, KSA), with the aim of associating the openings ratios (20%, 30%, 50%, 100%) with wall thickness (12 cm, 25 cm solid brick, 25 cm hollow brick) and energy consumption. Optimum alternatives for the opening ratio and construction materials with the lowest cooling loads during working hours are proposed.
Rapid determination of the content of digestible energy and metabolizable energy in sorghum fed to growing pigs by near-infrared reflectance spectroscopy1
Authors: Hu Jie , Li Juntao , Pan Long , Piao Xiangshu , Sui Li , Xie Gengnan , Zhang Shuai , Zhang Liying , Wang Junjun 
Published: November 2019

Abstract
The object of this study was to establish a new method to predict the content of DE and ME in sorghum fed to growing pigs by using near-infrared reflectance spectroscopy (NIRS). A total of 33 sorghum samples from all over China were used in this study. The samples were scanned for their spectra in the range of 12,000 to 4,000 cm−1. Based on principal components analysis of the spectra, the samples were split into a calibration set (n = 24) and a validation set (n = 9) according to the ratio of 3:1. With animal experiment values as calibration reference, the calibration models of DE and ME were established using partial least squares regression algorithm. Different spectral pretreatments were applied on the spectra to reduce the noise level. The best wavenumber ranges were also investigated. Results showed that DE and ME content in sorghum fed to growing pigs ranged from 14.57 to 16.70 MJ/kg DM and 14.31 to 16.35 MJ/kg DM, respectively. The optimal spectral preprocessing method for DE and ME was the combination of first derivative and multiplicative scatter correction. The most informative near-infrared spectral regions were 9,403.9 to 6,094.4 cm−1 and 4,605.5 to 4,242.9 cm−1 for both DE and ME. The best performance for DE and ME calibration models was the coefficient of determination of calibration (R2c) of 0.94 and 0.93, coefficient of determination of cross-external validation (R2cv) of 0.88 and 0.86, residual predictive deviation of cross-external validation (RPDcv) of 2.86 and 2.64, coefficient of determination of external validation (R2v) of 0.90 and 0.81, and residual predictive deviation of external validation (RPDv) of 3.15 and 2.35, respectively. There were no significant differences between the measured and NIRS predicted values for DE and ME (P = 0.895 for DE and P = 0.644 for ME). As the number of calibration samples increased from 24 to 33, the calibration performance of DE and ME models was improved, indicated by increased R2c, R2cv, and RPDcv values. In conclusion, NIRS quantitative models of the available energy in sorghum were established in this study. The results demonstrated that the content of DE and ME in sorghum could be predicted with relatively high accuracy based on NIRS and NIRS showed the superiority of speediness and practicality when compared with previous research methods including animal experiments, regression equations, and computer-controlled simulated digestion system.
Effects of central and peripheral administration of an acute-phase protein, α-1-acid-glycoprotein, on feed intake and rectal temperature in sheep
Authors: Gregg Brittany A , Parker Paxton A , Waller Kathryn M , Schneider Liesel G , Garcia Miriam , Bradford Barry , Daniel Joseph A , Whitlock Brian K 
Published: November 2019

Abstract
In rodents, an acute-phase protein, α-1-acid-glycoprotein (AGP), was shown to provide a link between inflammation and suppression of feed intake by acting as a leptin receptor agonist. The objective of this study was to determine the effects of AGP on feed intake and rectal temperature in sheep. Ewes were ovariectomized, implanted with a cannula into a lateral ventricle of the brain, and kept indoors in individual pens. Feed intake and rectal temperature were determined for sheep in all experiments. In the first experiment, ewes (n = 4) received 1 of 4 treatments [0 (control), 0.012 (low), 0.06 (medium), or 0.30 (high) mg/kg BW AGP] into the lateral ventricle (ICV). All sheep received all treatments in a Latin square design balanced for carryover effects with 10 d between treatments. In the second experiment, ewes (n = 10) received 1 of 2 treatments (0 and 3 mg/kg BW of AGP) intravenously (IV) in a completely randomized design. In the third experiment, ewes (n = 19) received peripheral treatments (IV) of an antipyretic [0 (control) or 2.2 mg/kg BW flunixin meglumine (FLU)] 30 min before receiving central AGP [0 (control) or 0.3 mg/kg BW of AGP] in a completely randomized design. All data were analyzed using a mixed model analysis of variance and tested for effects of treatment, time, and the interaction of treatment and time. Cumulative 48-h feed intake after administration of treatments was also determined. In the first experiment, there was no effect of ICV treatment (P = 0.37) on feed intake rate or on cumulative feed intake (P = 0.31). There was an effect of ICV treatment (P = 0.002) on rectal temperatures, which were greater (P &lt; 0.05) after the high dose of centrally administered AGP. In the second experiment, there was no effect of AGP administration IV on feed intake rate (P = 0.98), on cumulative feed intake (P = 0.41) or on rectal temperature (P = 0.71). In the third experiment, there was an effect of central AGP treatment (P &lt; 0.0001) and an interaction of central AGP and time (P &lt; 0.0001) on rectal temperature, whereas FLU had no effect (P = 0.93), demonstrating that AGP increased rectal temperatures regardless of antipyretic treatment. These results indicate that central AGP increases rectal temperature in sheep by pathways that do not involve prostaglandins. Further research is needed to determine whether AGP may be an important integrator of energy balance and inflammation.
Prevention of peritoneal dialysis-related peritonitis by regular patient retraining via technique inspection or oral education: a randomized controlled trial
Authors: Xu Ying , Zhang Yuhui , Yang Bin , Luo Suping , Yang Zhikai , Johnson David W , Dong Jie 
Published: November 2019

AbstractBackgroundThere has been little research on strategies for prevention of peritoneal dialysis (PD)-related peritonitis. We explored whether regular retraining on bag exchanges (via two methods: technique inspection and oral education) every other month could help reduce the risk of peritonitis in PD patients through a randomized controlled trial (RCT).MethodThis is an RCT conducted at Peking University First Hospital. A total of 150 incident patients receiving PD at our centre were included between December 2010 and June 2016 and followed up until June 2018. Patients were randomly assigned 1:1:1 to receive retraining on bag exchange via technique inspection, oral education or usual care. The primary outcome was time to the first peritonitis episode. Secondary outcomes were time to organism-specific peritonitis, transfer to haemodialysis and all-cause death.ResultsPatients in the technique inspection group, oral education group and usual care group (n = 50 for each group) were followed up for 47.5 ± 22.9 months. Time to first peritonitis was comparable between the groups. The technique inspection group showed a lower risk of first non-enteric peritonitis than the usual care group, while the oral education group did not show a significant benefit. The incidence of first non-enteric peritonitis in the usual care group (0.07/patient-year) was significantly higher than that in the technique inspection group (0.02/patient-year; P &lt; 0.01) but was comparable with that in the oral education group (0.06/patient-year). Transfer to haemodialysis and all-cause mortality were not significantly different between the groups.ConclusionsNeither technique inspection nor oral education significantly altered the risk of all-cause peritonitis compared with usual care, despite technique inspection showing a trend towards reducing the risk of non-enteric PD-related peritonitis.Trial registrationClinicalTrials.gov (NCT01621997).
A 7-Year-Old Child With Headaches and Prolonged Fever Associated With Oral and Nail Lesions
Authors: Martin Sophie , Balligand Elise , Peeters Julie , Nassogne Marie-Cécile , Mondovits Bénédicte , Loop Michèle , de Selys Ariel , Vanclaire Jean , Vermylen Christiane , De Bruyckere Jean- Jacques , Chatzis Olga , Puel Anne , Gilliaux Olivier , Van Der Linden Dimitri 
Published: November 2019

Abstract
A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by oral Fluconazole after regression of CNS lesions was observed on MRI. A complete immune evaluation was performed, and genetic analysis detected homozygous CARD9 mutation. CARD9 deficiency have been associated with invasive candidiasis in otherwise healthy patients.
Culture of the cerebrospinal fluid grew for multisensitive Candida albicans. Brain magnetic resonance (MRI) showed the presence of focal lesions in the left caudate nucleus and in the right cerebellar hemisphere. Medullar MRI showed diffuse meningeal nodular lesions. Treatment with intravenous amphotericin B liposomal was given during 6 months relayed by oral fluconazole after regression of CNS lesions was observed on MRI.
A complete immune evaluation was performed and genetic analysis detected a homozygous CARD9 mutation. CARD9 deficiency have been associated with invasive candidiasis in otherwise healthy patients.