bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERSONALIZED MEDICAL WEB SERVICES IN THE HEALTH CARE SYSTEM OF THE RUSSIAN FEDERATION
Authors: Maksimov D. Ye. , Mishkina A. I. , Karas S. I. , Finchenko Ye. A. 
Published: June 2020

Personal medical records of the patient in electronic form are the basis of modern health care information. With the development of medical technologies for patients have more opportunities to independently monitor various indicators of health. Currently, the process of self-observation of the patient is not possible without the use of modern medical equipment, allowing to measure the vital parameters of the body.It is important to storage and processing of information on the measured patient or family health indicators in a single system. This function is implemented in the Web services introspection of patient. Review of the most popular implementations of Web services listed in this article.
LONG-TERM RESULTS OF PROCTECTOMY WITH THE RECONSTRUCTION OF THE SPHINCTER, LEVATOR AND RESERVES-STORAGE TANK WITH LOW RECTAL CANCER
Authors: Bashirov S. R. , Trifonov M. N. , Tikhonov V. I. , Grishchenko M. Yu. 
Published: June 2020

Proctectomy with total mesorectal excision, resection of the internal sphincter, deep portions of the external sphincter and reductionwas performed on nine patients aged from 38 to 74 years with adenocarcinoma of low rectal cancer (T2N0M0 (n = 4), T2N1M0 (n = 1), T3N0M1 (n = 3), T4N2M1 (n = 1)), located in 8–25 mm from an anus. Simultaneously, atypical resections of the liver were performed on two of the patients. In the perineal section of the reduced intestine a sphincter was created from a smooth muscle cuff, a levator from not free serous, and a muscular flap, fixed to a forward wall of the small basin, and a reservoir of cross stitched submucosa site formed after the formation of a levator. 5 of the patients (T2N0-1M0)had no disease advance 3–9 years. They were able to hold firm feces, but were less able to hold liquid feces, and sometimes didn’t hold intestinal gas or differentiate between feces and gas, but were capable of ignoring an urge to defecate and to detain a defecation (level of a fecal continence on a scale of "Wexner score" (11 ± 1) of points).
CHARACTERISTICS OF LIPID METABOLISM IN PATIENTS WITH TYPE 1 DIABETES, DEPENDING ON THE AVAILABILITY OF DIABETIC MICROANGIOPATHY AND DIET
Authors: Samoilova Yu. G. , Yurchenko Ye. V. 
Published: June 2020

Was investigated 67 children (36 boys and 31 girls) in age from 6 to 18 years old, with type 1 diabetes patients who were treated at the Children's Hospital Endocrinology number 1 inTomsk, average age of the boys at the time of the survey amounted to (13.0 ± 0.4) years, girls – (13.5 ± 0.4) years. All children diagnosed with type 1 diabetes were under subcompensation. Clinical evaluation of patients included a medical history, physical examination, evaluation of physical development. A study of lipid profile (high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL), cholesterol (TC), triglycerides (TG), atherogenic index). Screening for diabetic retinopathy was performed by examining the fundus by direct ophthalmoscopy after pupil dilation. Diagnosis of diabetic nephropathy, retinopathy performed according to the classification. Patients were divided into groups depending on the presence of complications, and the level of compensation lipid metabolism (children with satisfactory compensation of lipid metabolism (total cholesterol level less than 5.2 mmol / l), children with poor compensation lipid metabolism (total cholesterol above 5.2 mmol / l)). Nature of the subjects studied nutrition using a questionnaire drawn up on the basis of the standard dietary questionnaire program CINDI, allowing to evaluate the eating habits by examining the frequency of intake of various foods, food preferences and priorities. Products, according to the lipid-lowering diet on the recommendations of the European Society for atherosclerosis were combined and divided into groups according to frequency of use: commonly used products, and rarely use the products. Mathematical treatment of the results was performed using the software package Statistica 5.5 for Windows. In the first phase expected to total group performance statistics – the arithmetic mean value M and the error of the mean m, as well as visualization of the distribution of values was performed using frequency histograms. To select a criterion to assess the significance of paired differences check compliance form normal distribution using the criterion χ2, and also controlled the general equality of variances using the F-test Fisher. Given that these conditions are satisfied only part of the empirical distributions of features tested the hypothesis that the general average in all cases was performed using Mann–Whitney U-test for independent variables. Null hypothesis was rejected when p < 0.05.In the study of lipid metabolism in patients with type 1 diabetes, no increase in the level of cholesterol, triglycerides, HDL, LDL and VLDL – cholesterol in patients with a combination of diabetic nephropathy and retinopathy compared with patients with type 1 diabetes without diabetic microangiopathy. Investigation of the nature of power in patients with type 1 diabetes, allowed us to estimate its impact on lipid metabolism.
IMMUNITY STATE IN THE OFFSPRING OF RATS EXPOSED ANTIGENS TOXOPLASMA GONDII
Authors: Sokolova T. F. , Novikov D. G. , Indutny A. V. , Turok N. Ye. , Velichko G. N. 
Published: June 2020

Today the questions about possibility of development disturbances in the immune system of the fetus and the newborn in chronic toxoplasmosis are poorly understood. Aim of research: to detect immunological disturbances in the offspring of rats which have been administered antigens T. gondii.Two series of experiments was performed. In these experiments white female Wistar rats in the III trimester of pregnancy have been administered corpuscular antigen T. gondii. The 60 days-old offspring of these rats have been included in study group of 137 animals. CD3+ cells count was performed in peripherical blood and standard suspension of splenocytesrats offspring. Peripherical blood cells count was performed in the blood of the rats offspring. In the second experiment rats offspring have been administered sheep erythrocytes in 5 days, before euthanasia. In spleen of this rats antigen-produced cells was counted.In control group was included 118 animals, which was born from white female Wistar rats have been administered 0,9% NaCl solution. CD3+ cells was detected in Cytomics FC500 flow cytometry analyzer (Beckman Coulter,USA) by use rats origne-specifed monoclonal antibodies Anti-Rat CD3-FITC (Beckman Coulter,USA). Hematological parameters was assessed by use hematological analyzer Excell-22 (USA).We observed, that CD3+ lymphocytes and antigen-produced cells was decreased in test group (degress of decrease CD3+ cells was 17,2%; р = 0,003 in spleen vs. control group, degress of decrease antigen-produced cells was 27,3%; р = 0,03 vs. control group). Number of leukocytes was increased in in test group (34,5%; р = 0,009 vs. control group). Power and strength correlation pleiades between studied blood and spenal markers were higher in in test group vs. control group (∑Gi = 16; ∑Di = 4,38 vs. ∑Gi = 13; ∑Di = 2,28). This phenomenon is probably due to the development adaptive reactions disruption in the immune system and development secondary immunodeficiency states in the offspring of rats.Violations of immunoreactivity, as well as disruption the possibility of operational restructuring of the immune system and choosing the best immune response in the offspring of rats whose perinatal development take place under the effect of antigens T. gondii, persists for a long time – within 60 days of postnatal life.
SODIUM-POTASSIUM-CHLORIDE COTRANSPORT IN THE REGULATION OF VASCULAR MYOGENIC TONE
Authors: Orlov S. N. , Koltsova S. V. , Anfinogenova Ya. D. , Kapilevich L. V. , Gusakova S. N. , Smagliy L. V. , Baskakov M. B. , Medvedev M. A. 
Published: June 2020

The article discusses the data on the functioning of Na+,K+,2Cl– cotransport – the carrier providing electroneutral symport of sodium, potassium and chloride, as well as molecular mechanisms of the regulation and physiological significance of this carrier. We analyzed the novel data on involvement of ubiquitous isoform of Na+,K+,2Cl–cotransporter (NKCC1) in regulation of vascular smooth muscle contraction, and role of this carrier in the regulation of cell volume and intracellular chloride concentration.
EFFECT OF ANTIHELMINTHIC THERAPY ON THE SKIN PROCESS IN ROSACEA PATIENTS IN COMBINATION WITH OPISTHORCHIASIS
Authors: Aripova M. L. 
Published: June 2020

The article presents results of examination of 144 patients, including 64 patients with rosacea in combination with chronic opisthorchiasis (group 1) and 80 patients with rosacea without opistorchiasis (group 2). Rosacea patients with concomitant chronic opisthorchosis revealed more severe clinical variants. Mean values of the index scale diagnostic assessment of rosacea is significantly higher than in patients rosacea without helminthiasis, indicating a more severe course. Dissatisfaction with the quality of life in patients with rosacea in combination with chronic opisthorchiasis was significantly higher than in patients with rosaceaonly. Patients with rosacea in combination with chronic opisthorchiasis reveled prevalence of anxiety and depression in scale of HADS. There are also were a comparative analysis of the clinical picture in patients with rosacea anthelmintic therapy and without deworming.
STRUCTURE OF THE NODULAR GOITER IN CHILDREN
Authors: Rogova O. S. , Samsonovа L. N. , Okminyan G. F. 
Published: June 2020

For today the question of early diagnosis of nosological variants, the method of treatment and prevention of nodular goiter in children is still not fully resolved. There is a few available literature data about study of this problem in children. Objective: to study morphofunctional structure of thyroid nodules in children.The article provides information consisting of the results of a retrospective analysis of case histories of 73 patients, operated with nodular goiter in Z.A. Bashlyaeva Children’sCityClinicalHospital(Moscow) from 2003 to May 2015. The examination included an evaluation of the functional status of the pituitary-thyroid system: there were investigated serum thyroxine, triiodothyronine and thyroid stimulating hor-mone, also was performed thyroid scintigraphy 99mТc. In the postoperative period, there was carried out a final verification of the diagnosis according to the results of the histological conclusion. The histologi-cal type of nodal disease was defined by the WHO classification of 2004. It was established that in the structure of a single-node goiter in children prevail nodular colloid goiter with equal frequency in boys and girls, with the same frequency occurs thyroid adenoma, but more often in girls than in boys. The multinodular goiter equally often detected in girls and boys both nodular goiter colloidal with varying degree of proliferation and colloid in combination with follicular thyroid adenoma. "Hot" nodes in the multinodular goiter are more common than in the single-node goiter and more fre-quently in girls than in boys. The half of children with nodular pathology have "hot" nodes and one out of every three – decompensated form of functional autonomy. Decompensated form of functional autonomy of the thyroid gland in children with "hot" nodes detects regardless of the number of nodes. Papillary thyroid cancer occurs not only in patients with a single-node, but with a multinodular goiter. The results allow to draw conclusions about the heterogeneity of the morphological structure as a single-node and multinodular goiter in children, including papillary thyroid cancer.
THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO
Authors: Nosareva O. L. , Stepovaya Ye. A. , Ryazantseva N. V. , Shakhristova Ye. V. , Vesnina O. N. , Novitsky V. V. 
Published: June 2020

The formation of oxidative stress lies at the heart of many frequent and socially-important diseases. Blood lymphocytes are the cells which provide immunological control of our organism. As a result of their function implementation blood lymphocytes contact with different endogenic and exogenic factors, which can lead to active oxygen species production activation, macromolecules oxidative modification and to cell survival alteration. At the present time it is essential to expand and deepen the fundamental knowledge of blood lymphocytes apoptosis regulation peculiarities. The research objective was to establish the interaction among alterations of glutathione system condition, carbonylation level, protein glutathionylation and caspase-3 activity in blood lymphocytes during oxidative stress in vitro.Material and Methods. The material for research was blood lymphocytes cultivated with addition of hydrogen peroxide in final concentration of 0,5 mmol and/or protein SH-group inhibitor N-ethylmaleimide – 5 mmol, protector – 5 mmol – 1,4-dithioerythritol. Reduced, oxidized and protein-bound glutathione concentration was measured by method of spectropho-tometry, additionally, the ratio size of reduced to oxidized thiol fraction was estimated. With help of enzymoimmunoassay the level of protein carbonyl derivatives was evaluated; caspase-3 activity was registered by spectrofluorometric method.Results. Protein SH-group blocking in blood lymphocytes during oxidative stress in vitro was accompanied by protein-bound glutathione concentration rapid decrease in connection with increase of protein carbonyl derivatives content and caspase-3 activity. Protein SH-group protection in blood lymphocytes during oxidative stress in vitro was accompanied by concentration increase of protein-bound glutathione and protein carbonyl derivatives under comparable values of enzyme activity under study.Conclusion. The carried out research shows that caspase-3 and protein-bound glutathione are the molecular targets of selective control over programmed cell death. The received indices of caspase-3 activity change and protein-bound glutathione concentration alteration in blood lymphocytes during oxidative stress in vitro can be used when elaborating target therapy approaches to diseases accompanied by apoptosis disregulation.
THE EVALUATION STUDIES OF KAMPUNG KB IN CENTRAL JAVA
Authors: Handayani Arri , Najib  , Ardini Sukma Nur , Yulianti Padmi Dhyah 
Published: June 2020

Kampung KB becomes one of the strategic innovations to implement the priority activities of the KKBPK Program as an effort to achieve the target of the Development of Population and Family Planning Control (Pembangunan Bidang Pengendalian Penduduk dan Keluarga Berencana). The data collected through a qualitative approach. The instrument used was an interview guide to conduct an in-depth interview with various participants. The location of the study was chosen by purposive technique; Magelang, Sukoharjo, and Temanggung. The data are grouping into input, process, and output. Related to the input, the establishment of Kampung KB is already by the guidelines, people's participation is quite good, but the support of facilities and infrastructure is still at a minimum level. About the process, the consuming data came from 2015, coaching and movement are not regularly scheduled. The last relates to the output, that is Kampung KB activities such as Tri Bina (BKB, BKR, BKL), UPPKS, PIK-R, learning guidance, and libraries, while activities from across sectors include drainage, privies, corn seedling, home industry training, duck livestock training, and infrastructure improvements. However, the improvement of the KKBPK program achievements has not been completed, even though it changes the social welfare.
Keywords: input, kampung KB, output, process

Studi Evaluasi Kampung KB di Jawa Tengah
Abstrak
Kampung KB menjadi salah satu inovasi strategis untuk dapat mengimplementasikan kegiatan-kegiatan prioritas Program KKBPK sebagai upaya pencapaian target Pembangunan Bidang Pengendalian Penduduk dan Keluarga Berencana. Pengumpulan data melalui pendekatan kualitatif. Instrumen yang digunakan pedoman wawancara untuk melakukan wawancara mendalam dengan berbagai informan. Lokasi penelitian dipilih secara purposif yaitu kota magelang, kabupaten sukoharjo, dan kabupaten temanggung. Berdasarkan hasil penelitian data pendekatan kualitatif, terdapat tiga kelompok yang meliputi input, proses, output. Pertama, berkaitan dengan input yakni pembentukan wilayah kampung KB sudah sesuai pedoman, partisipasi masyarakat cukup baik, namun dukungan sarana dan prasarana masih sangat minim. Kedua, berkaitan dengan proses yakni data, pembinaan dan penggerakan belum terjadwal secara rutin. Ketiga, berkaitan dengan output yakni bentuk kegiatan dikampung KB diantaranya Tri Bina (BKB, BKR, BKL), UPPKS, PIK-R, bimbingan belajar dan perpustakaan pintar, sedangkan kegiatan dari lintas sektor diantaranya meliputi drainase, jambanisasi, pembibitan jagung, bank sampah, pelatihan home industry, pelatihan ternak bebek, dan perbaikan infrastruktur. Namun, peningkatan capaian program KKBPK belum sepenuhnya terpenuhi, walaupun membawa sedikit perubahan pada kesejahteraan masyarakat.
Kata kunci: input, kampung KB, output, proses
Medial Condyle Fractures of the Humerus in the Pediatric Population: Diagnostic Challenges
Authors: Zukotynski Brian K. , Alswang Jared M. , Silva Mauricio 
Published: June 2020

Case:
We describe 3 cases of children, ages ranging from 3 years 11 months to 6 years 3 months, who presented with medial condyle fractures (MCF) over a 3-year period with 3 distinct treatment outcomes.

Conclusion:
Pediatric MCFs are rare and difficult to diagnose, but evidence of severe edema in the presence of an apparent avulsion fracture on the medial side of the elbow in patients younger than 6 years old could suggest the possibility of a displaced fracture of the medial humeral condyle and additional assessment involving evaluation under anesthesia, arthrography, or advanced imaging may be warranted. Open reduction with internal fixation should be considered for displaced fractures.
Simultaneous Posterior Shoulder Dislocation and Acromioclavicular Joint Separation: Single-Stage Arthroscopic Treatment of Combined Injuries
Authors: Toft Felix , Scheibel Markus 
Published: June 2020

Case:
We report on a patient who received arthroscopic treatment after a unique traumatic combined injury comprising a posterior shoulder dislocation with posterior labrum damage, a reverse Hill-Sachs lesion, and a concomitant Rockwood type-V acromioclavicular joint dislocation.

Conclusion:
Arthroscopy was applied to address all pathologies in a single-stage procedure. The outcome of reduced operating and patient recovery time suggests that our intervention is ideal for this specific indication.
Joëlle Ducos and Christopher Lucken (eds.), Richard de Fournival et les sciences au XIIIe siècle. Micrologus Library 88, Firenze, SISMEL, 2018, vi + 443 pp., ISBN: 97888845 08430. Cloth €68
Authors: DELAURENTI BÉATRICE 
Published: June 2020

Reseñado por BÉATRICE DELAURENTI EHESS,
Centre de Recherches Historiques, Paris, FR
beatrice.delaurenti@ehess.fr
Peningkatan Kompetensi Guru dalam Mengintegrasikan HOTS (Higher Order Thinking Skills) Pada Pembelajaran
Authors: Hanik Umi , Mardiyana Isna Ida , Rosid Abdul 
Published: June 2020

Salah satu masalah dalam pelaksanaan kurikulum 2013 adalah terkait pengintegrasian keterampilan berpikir tingkat tinggi atau HOTS (Higher Order Thinking Skills) dalam pembelajaran. Tujuan kegiatan ini adalah untuk memberikan pelatihan dan pendampingan kepada guru-guru khususnya di jenjang sekolah dasar. Metode yang digunakan yaitu, 1) tahap pra pelaksanaan kegiatan: wawancara dan observasi, dan 2) tahap pelaksanaan kegiatan: ceramah, tanya jawab, praktek, dan 3) tahap pasca pelaksanaan kegiatan: pendampingan intensif secara online melalui grup whatsapp . Kegiatan ini diikuti oleh guru-guru di Kecamatan Klampis, Kecamatan Sepulu dan Kecamatan Tanjung Bumi yang lokasi sekolahnya berada dalam wilayah penempatan KKN (Kuliah Kerja Nyata) yakni berada di beberapa desa di Kecamatan Klampis, Sepulu dan Tanjung Bumi. Struktur materi yang diberikan adalah 1) pemantapan kurikulum 2013, 2) pembelajaran berbasis HOTS, 3) penyusunan soal berbasis HOTS, 4) pengembangan perangkat pembelajaran berbasis HOTS. Hasil kegiatan ini adalah peserta berhasil: 1) meningkatkan pemahaman tentang kurikulum 2013 dan pembelajaran berbasis HOTS, 2) menyusun soal berbasis HOTS, dan 3) mengembangkan perangkat pembelajaran berbasis HOTS.
The influence of heat treatment on the structural phase state and durometric properties of small-sized castings from a copper alloy Cu-Cr-Al
Authors: Marukovich E. I. , Kukareko V. A. , Kharkov V. A. , Kushnerov V. A. , Sazonenko I. O. 
Published: June 2020

The effect of heat treatment on the structural-phase state and hardness of small-sized castings made from the Cu-Cr-Al copper alloy obtained by casting in a water-cooled metal mold is studied. Using X-ray diffraction analysis, it was found that the castings consist of a matrix solid solution based on copper. The increased value of the crystal lattice parameter of the copper phase is associated with aluminum atoms dissolved in it. After a low-temperature (450 °C) tempering for 10 hours, the crystal lattice parameter of the matrix solid solution decreases, which is associated with the formation of the Al8Cr5 intermetallic compound on the surface of the casting.It is established that after heat treatment (hardening and tempering), the hardness of castings from the Cu-Cr-Al alloy increases by 1.5 times.
Spectral analysis of UV-spectrum elements in steel using portable optical emission spectrometers
Authors: Bankova Zh. N. , Birisen T. S. 
Published: June 2020

Optical emission spectroscopy is used to determine the mass fraction of elements such as carbon, silicon, manganese, phosphorus, sulfur, chromium, nickel, copper, aluminum, molybdenum, vanadium, titanium, arsenic, tin, boron, calcium, etc. Most of the analytical lines of the analyzed elements are located in the visible light spectrum, but the analytical lines of carbon, phosphorus and sulfur are located in the ultraviolet radiation spectrum.Ultraviolet radiation (UV radiation) is electromagnetic radiation that occupies the spectral range between visible and x ray radiation. The wavelengths of UV radiation are in the range from 10 to 400 nm. The area of UV radiation is divided into: near from 400 to 200 nm; far from 380 to 200 nm; vacuum from 200 to 10 nm.Structural particularities of the structure of the optical system of stationary spectrometers allow determining the mass fraction of chemical elements, including phosphorus and sulfur, with sufficient accuracy and reliability. This article discusses the possibility of determining the mass fractions of phosphorus and sulfur, the analytical lines of which lie in the area of ultraviolet radiation, using portable optical emission spectrometers.