bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Application of HPLC Method for Clinical Pharmacokinetic Study of Domperidone
Authors: Neerati Prasad , A Bhargavi Latha , Kumar Y. Shravan , Rao Y Madhusudan 
Published: August 2020

A simple and sensitive high performance liquid chromatographic method for quantification of domperidone in human serum was developed and validated. Domperi-done and internal standard (IS) propranolol hydrochloride were extracted into acetonitrile and separated using an isocratic mobile phase on a Phenomenx C18 column. The eluent was monitored by UV detector at 270 nm at a flow rate of 1.0 mL min–1. The linearity range of proposed method was 2.5–1000 ng/ml. The intra-day and inter-day coefficient of variation and percent error values of the assay method were less than 15% and mean recovery was more than 97 and 96% for domperidone and IS, respectively. The method was found to be precise, accurate and specific during the study. The method was successfully applied for pharmacokinetic study of domperidone in humans.
Improving Hepatobiliary Imaging as a Physiologic Test with Superior Clinical Outcomes
Authors: Gayed Isis , Dawood Lydia , Xu Zhang , Rizk Grace , Dupont Andrew , Atta Monica , Robinson Emily 
Published: August 2020

AbstractThis study aims at prospectively evaluating the difference in the effect of cholecystokinin (CCK) and half-and-half milk (HHM) administered in the same patient on gallbladder contractility and correlation with clinical outcomes. Upon gallbladder visualization during standard hepatobiliary imaging, 0.02 μg/kg of CCK was injected over 3 min, and additional 30 min of dynamic imaging was obtained. Patients with gallbladder ejection fraction (GBEF) <35% after CCK were administered 8 oz of HHM followed by 30 min of imaging. The GBEF was recalculated. The number of patients whom GBEF changed from below 35% (abnormal) after CCK to above 35% (normal) after HHM was recorded. Follow-up of the clinical outcome at 6 months was performed. Fifty patients with abnormal GBEF were prospectively included. The average GBEF after CCK was 14.7% ± 8.5% and after HHM was 30.7% ± 20.8%. The average increase in GBEF with HHM was 16.0% ± 22.2%. The GBEF changed from abnormal to normal in 17 patients (34%). The remaining 33 patients remained abnormal. Clinical outcomes at 6 months were available in 47 patients. Cholecystectomy was performed in 60% of patients with abnormal GBEF with CCK and HHM with resolution or improvement of pain. Two of 16 patients (12%) with abnormal GBEF after CCK but normal after HHM had cholecystectomies with pain improvement, while 8 out of these patients (50%) were diagnosed and treated with other disorders and improved. Hepatobiliary imaging with HHM stimulation is a superior physiologic test which can lower the number of unnecessary cholecystectomies and misdiagnoses as functional cholecystitis.
Flavodoxin in a binary surfactant system consisting of the nonionic 1-decanoyl-rac-glycerol and the zwitterionic lauryldimethylamine-N-oxide: Molecular dynamics simulation approach
Authors: Bazaziyan Behnaz , Bozorgmehr Mohammad Reza , Momen-Heravi Mohammad , Beyramabadi S. Ali 
Published: August 2020

Due to the short time constant of the spin-spin relaxation process, there is a limitation in the preparation of NMR sample solution for large proteins. To overcome this problem, reverse micelle systems are used. Here, molecular dynamics simulation was used to study the structure of flavodoxin in a quaternary mixture of 1-decanoyl-rac-glycerol, lauryldimethylamine-N-oxide, pentane and hexanol. Hexanol was used as co-solvent. Simulations were performed at three different co-solvent concentrations. The proportion of components in the mixture was selected according to experimental conditions. For comparison, simulation of flavodoxin in water was also performed. The simulation results show that the C$\alpha$-RMSD for the protein in water is less than for the surfactant mixture. Also, the radius of gyration of flavodoxin increased in the presence of surfactants. The distance between the two residues trp-57 and phe-94, as a measure of protein activity, was obtained from the simulations. The results showed that in the surfactant mixtures this distance increases. Analysis of the secondary structure of the protein shows that the N-terminal part of the flavodoxin is more affected by surfactants. The flavodoxin diffusion coefficient in the surfactant mixture decreased in relation to its diffusion coefficient in water.
Pregnancy follow-up and outcomes of patients diagnosed with fetal hypoplastic left heart syndrome
Authors: Yücel Çelik Özge , Yılmaz Osman , Obut Mehmet , Keleş Ayşe , Gültekin Çalık Mine , Yücel Aykan , Şahin Dilek 
Published: August 2020

Objective: The study aimed to evaluate the follow-up and outcomes of patients diagnosed with fetal hypoplastic left heart syndrome in the prenatal period.
Materials: Between January 2017 and June 2019 the data of 36 patients diagnosed with fetal hypoplastic left heart syndrome (HLHS) in Etlik Zübeyde Hanım Woman’s Health Care Training and Research Hospital (EZH) were evaluated retrospectively. All patients who suspected for any fetal or cardiac anomaly were evaluated in detail ultrasound by two senior perinatologists and a pediatric cardiologist fort a detailed cardiac evaluation. The demographic characteristics, pregnancy follow-up and maternal and fetal outcomes of patients were evaluated.
Results: During the study period fetal echocardiography was performed for 10.377 patients. A totally 382 (3.7%) fetuses were diagnosed with congenital heart diseases and 36 (9.4%) of these fetuses were diagnosed with hypoplastic left heart syndrome. Additional extracardiac anomalies were detected in 13 (36.1%) fetuses. Concomitant fetal cardiac anomalies were detected in 15 patients and ventricular septal defect (n: 11) and double outlet right ventricle (n:8) were the most common concomitant cardiac anomalies. Eight pregnancies with fetal HLHS were terminated. The data of 10 patient’s newborns were obtained and none of them lived up to a year.
Conclusion: The study revealed that the majority of patients with fetal HLHS are in low-risk population thus the routine fetal cardiac evaluation is of great importance. The prognosis and outcome of the pregnancy diagnosed with fetal HLHS are poor. The option of termination of the pregnancy should be considered.
Extrapulmonary Manifestations of COVID-19: A Call to Extra Vigilance and Tribute to Dr Li Wenliang
Authors: Onoja AM , Jombo GTA , Onoja AT , Nwannadi AI , Aba IH 
Published: August 2020

COVID-19 pandemic has covered all continents and virtually all countries of the world infecting millions of people with several hundred thousands of death. It was first brought to the attention of a Chinese ophthalmologist Dr Li Wenliang. The disease which was first believed to be solely associated with the lungs and respiratory system has now shown that the spectrum of organ involvement of the disease is much larger than earlier believed. While lung and pulmonary features still account for a much larger presentation of the disease, other clinical manifestations such as fulminant myocarditis, arteriovenous thromboembolism, disseminated intravascular coagulopathy, intracerebral haemorrhage, diarrhea, hypoxic encephalopathy, septicaemia and detection of SARS-CoV-2 particles in stool, saliva and semen of infected individuals are also becoming less infrequent. Haematologic manifestations of hypercoagulable blood are commonly reported among hospitalized COVID‐19 patients. An elevated D‐Dimer, that is rising in the course of disease may signifies disease deterioration. Prolonged PT and aPTT and increased fibrin degradation products with severe thrombocytopenia have been associated with life-threatening disseminated intravascular coagulation (DIC). Physicians should therefore be on a watch out for these features in the management of patients and be ready to spot out other new surprises by the disease. This should be through deepening of curiosity by health personnel in the assessment and management of patients to spot out early surprises of COVID-19 to strengthen the sustenance of the ongoing control of the pandemic
The Applicability of Item Response Theory Based Statistics to Detect Differential Item Functioning in Polytomous Tests
Authors: Ibrahim Abdul Wahab 
Published: August 2020

The study used statistical procedures based on Item Response Theory to detect Differential Item Functioning (DIF) in polytomous tests. These were with a view to improving the quality of test items construction. The sample consisted of an intact class of 513 Part 3 undergraduate students who registered for the course EDU 304: Tests and Measurement at Sule Lamido University during 2017/2018 Second Semester. A self-developed polytomous research instrument was used to collect data. Data collected were analysed using Generalized Mantel Haenszel, Simultaneous Item Bias Test, and Logistic Discriminant Function Analysis. The results showed that there was no significant relationship between the proportions of test items that function differentially in the polytomous test when the different statistical methods are used. Further, the three parametric and non-parametric methods complement each other in their ability to detect DIF in the polytomous test format as all of them have capacity to detect DIF but perform differently. The study concluded that there was a high degree of correspondence between the three procedures in their ability to detect DIF in polytomous tests. It was recommended that test experts and developers should consider using procedure based on Item Response Theory in DIF detection.
Compartilhando olhares sobre a terapia ocupacional em um centro de tratamento de queimados / Sharing views about occupational therapy at a burn treatment center
Authors: Azevedo Manuella Matos de , Castro Ivana Monique Corpes 
Published: August 2020

No Brasil, a Terapia Ocupacional sempre esteve ligada ao contexto hospitalar, e através dos tempos veio se consolidando como profissão da área da saúde que busca por meio do fazer humano o tratamento de diversas patologias com intuito principal de devolver a funcionalidade do indivíduo, porém, segue em busca de maior reconhecimento profissional. Por ainda estar em busca do seu valimento, este estudo intenta analisar as percepções acerca do terapeuta ocupacional na visão da equipe multidisciplinar. Esta pesquisa tem uma abordagem qualitativa fenomenológica do tipo descritiva exploratória, sendo desenvolvida com a equipe multiprofissional do Centro de Tratamento de Queimados do Hospital Metropolitano de Urgência e Emergência. Por meio das falas expostas percebe-se que, mesmo valorizado, pouco se entende do propósito do terapeuta ocupacional, porém, ainda foi evidenciado um olhar mais abrangente da prática deste profissional. Desta forma, refletiu-se sobre a necessidade de os terapeutas ocupacionais buscarem seu lugar junto a equipe do Sistema Único de Saúde, ressaltando sua importância no tratamento do queimado, e de se fazerem reconhecidos perante a equipe multidisciplinar. AbstractIn the Brazilian context Occupational Therapy is always linked to the hospital context, has been consolidating itself through the times as a profession in the health area that seeks return the individual's functionality but continues in search of greater professional recognition. Still searching of your validity, this study tries to analyze the perceptions about the occupational therapist in the view of the multidisciplinary team. This research has a qualitative phenomenological approach of the exploratory descriptive type, being developed with the multiprofessional team of the Centro de Tratamento de Queimados of the Hospital Metropolitano de Urgência e Emergência, Brasil. Through the spoken lines, it was perceived that, even when valued, little is known about the purpose of the occupational therapist, but a more comprehensive look has been evidenced than it is. However there is need for occupational therapists to seek their place with the minimum team of the Unified Health System, emphasizing its importance in the treatment of burnt and to make themselves recognized by the multidisciplinary team was reflected.Keywords: Hospitalization; Occupational therapy; Burn units.
Efeito de posturas estáticas e dinâmicas na distribuição da pressão nádega-almofada em um caso de tetraplegia por lesão medular/The effect of statistical and dynamic positions in the distribution of buttock-cushion pressure in a case of tetraplegia
Authors: Mendes Paulo Vinicius Braga , Da Cruz Daniel Marinho Cezar 
Published: August 2020

Introdução: as úlceras por pressão são complicações frequentes em pacientes com lesão medular. Almofadas de ar são apontadas como as mais indicadas para aliviar a pressão de interface e prevenir úlceras. Objetivo: Analisar, em um caso de tetraplegia por lesão medular, o efeito da distribuição da pressão de interface nádega/almofada em posturas estáticas e dinâmicas e verificar se o uso de uma almofada nova interfere na distribuição da pressão. Método: A análise da pressão de interface foi realizada durante duas situações distintas: com o participante sentado em postura estática; e mais uma etapa utilizando a cadeira de rodas para a locomoção. Para a avaliação da pressão de interface foram utilizadas duas almofadas Roho® Quadtro Select High Profileâ„¢: uma em uso pela participante e outra fornecida pelos pesquisadores. Resultados: Foram analisados: pressão média, pico de pressão e área de contato na interface nádega/almofada nas duas etapas de coletas de dados. A almofada fornecida pelo estudo apresentou índices melhores para pressão média, pico de pressão e área de contato. Conclusão: O estudo traz evidências da importância de manter a calibração de almofadas para sujeitos lesados medulares para prevenção de úlceras de pressão. Abstract Introduction: pressure ulcers are frequent complications in patients with spinal cord injury. Air cushions are appointed as the most appropriate to relieve the interface pressure and prevent pressure ulcers. Objective: To analyze the effect of the distribution of the buttock / cushion interface pressure under static and dynamic posture and check the use of a new cushion interferes with the pressure distribution in a case of tetraplegia after spinal cord injury. Method: Analysis of interface pressure was performed for two different situations, with the participant sitting in static and one more step using the wheelchair for locomotion. For the evaluation of interface pressure were used two Roho® Quadtro Select High Profile â„¢ cushions: one used by the participant and another provided by the researchers. Resulted: Was analyzed the mean pressure, peak pressure and the contact area in buttock/cushion in both data collect. The cushion provided by the study presented better indices for mean pressure, peak pressure and contact area. Conclusion: The study provides evidence of the importance of maintaining cushion calibration for spinal cord injured individuals to prevent pressure ulcers.Keywords: Cushion; Spinal Cord Injury; Assistive Technology.
A construção de mobiliário adaptado para facilitar a inclusão escolar de uma estudante com paralisia cerebral/The construction of adapted furniture to support the education of a student with cerebral palsy
Authors: Calheiros David dos Santos , Mendes Enicéia Gonçalves , Silva Flávia Calheiros da , Santos Emanuele Mariano de Souza , Nabuco Thais Quintela de Andrade , Dounis Alessandra Bonorandi 
Published: August 2020

Resumo Analisou-se a construção de um mobiliário adaptado, a partir da parceria entre setores da saúde e educação, para apoiar a escolarização de uma estudante com paralisia cerebral. A confecção do recurso pautou-se na necessidade de ajustar a postura da estudante, que possui um grave quadro motor, para sua participação independente e autônoma em atividades de roda, no chão. A criação do recurso implicou em recorrentes ajustes, oficinas e elaboração de materiais instrucionais. De modo particular, favoreceu a participação da estudante nas atividades em roda, colocando-a na mesma posição que seus pares e proporcionando maior interação em sala de aula. Abstract We sought to analyze the construction of adapted furniture, based on the association between health and education sectors, to support the schooling of a student with cerebral palsy. The preparation of the resource was based on the need to adjust the position of the student, who has a serious motor picture, for independent and autonomous participation in wheel activities, on the ground. The creation of the resource involved in recurrent adjustments, workshops and the preparation of instructional materials. In a particular way, it favored the participation of the student in the activities in wheel, leaving her in the same position as her peers and providing more interaction in the classroom.Keywords: Special Education; Assistive Technology; Cerebral Palsy.
Avaliação interdisciplinar em um centro especializado em reabilitação/ Interdisciplinary evaluation in a rehabilitation specialized center
Authors: Morimoto Sandra Yoshie Uraga , Portela Catharina Machado , Coelho Weldma Karlla , Jucá Adriana Lobo 
Published: August 2020

Tendo em vista a importância do caráter interdisciplinar dos serviços de reabilitação de pessoas com deficiência, buscou-se apresentar a avaliação interdisciplinar utilizada em um Centro Especializado em Reabilitação do Recife. A avaliação, baseada na Classificação Internacional de Funcionalidade, Incapacidade e Saúde, faz parte do processo de admissão dos pacientes ao serviço de reabilitação e conta com a participação de Terapeuta Ocupacional, Fisioterapeuta e Fonoaudiólogo, com o objetivo de atender as diferentes demandas dos pacientes com comprometimento neurológico de maneira cooperativa entre as profissões Logo, foi possível perceber sua eficiência na visualização do sujeito integral, permitindo maior precisão no planejamento terapêutico. Abstract: Bearing in mind the importance of the interdisciplinary character of rehabilitation services, this analysis seeks to present an interdisciplinary evaluation used in a specialized rehabilitation center in Recife. The evaluation, based on the International Classification of Functioning, Disability and Health, is part of the patients admission process. Occupational therapists, physiotherapists and speech therapists take part in the process. It aims to meet different demands from neurologically demaged patients in a cooperative manner among the three perspectives. Therefore, it was possible to notice its efficiency in seeing the patient as a whole, bringing greater precision to the therapeutical planning.Key words: Rehabilitation; International Classification of Functioning, Disability and Health; Disability Evaluation.Resumen: Dada la importancia del carácter interdisciplinario de los servicios de rehabilitación de personas con discapacidad, se buscó presentar la evaluación interdisciplinaria de un Centro Especializado en Rehabilitación del Recife. La evaluación, basada en la Clasificación Internacional de Funcionalidad, Incapacidad y Salud, forma parte del proceso de admisión de los pacientes al servicio y cuenta con un Terapeuta Ocupacional, Fisioterapeuta y Fonoaudiólogo, cuyo objetivo es atender las diversas demandas de los pacientes con enfermedad neurológica, de manera cooperativa entre las profesiones. Luego, fue posible percibir su eficiencia en la visualización del sujeto integral, permitiendo mayor precisión en el planeamento terapéutico.Palabras claves: Rehabilitación; Classificación Internacional del Funcionamiento, de la Discapacidad y de la Salud; Evaluación de la Discapacidad.
Pandemia, desigualdade social e necropolítica no Brasil: reflexões a partir da terapia ocupacional social/Pandemic, social inequality and necropolitics in Brazil: reflections from social occupational therapy
Authors: Bardi Giovanna , Bezerra Waldez Cavalcante , Monzeli Gustavo Artur , Pan Lívia Celegati , Braga Iara Falleiros , Macedo Maria Daniela Corrêa de 
Published: August 2020

A pandemia provocada pela CoVid-19 tem se expandido e levado à uma grave crise mundial. A partir do contexto brasileiro, este ensaio objetiva reunir, sob a perspectiva da terapia ocupacional social, reflexões sobre essa pandemia com foco nas questões socioeconômicas e políticas. Concluímos que os impactos dessa crise possuem a marca da desigualdade, uma vez que expõem a população mais pobre a maiores riscos de contaminação e à intensificação das vulnerabilidades sociais. O Estado brasileiro tem empreendido uma necropolítica, que pouco responde às demandas desses grupos populacionais e imputa à classe trabalhadora uma conta que é estrutural do capitalismo. AbstractThe pandemic caused by CoVid-19 has been expanding and leading to a serious global crisis. From the Brazilian context, this essay aims to gather, from the perspective of social occupational therapy, reflections on this pandemic with a focus on socioeconomic and political issues. We conclude that the impacts of this crisis have the mark of inequality, since it exposes the poorest population to greater risks of contamination and to the intensification of social vulnerabilities. The Brazilian State has undertaken a necropolitics, which produces few responses to the demands of these population groups and charges the working class with a bill that is structural of capitalism.Keywords: Pandemics, social inequality, occupational therapy.ResumenLa pandemia causada por CoVid-19 se ha expandido y ha llevado a una grave crisis mundial. Desde el contexto brasileño, este ensayo tiene como objetivo reunir, desde la perspectiva de la terapia ocupacional social, reflexiones sobre esta pandemia con un enfoque en temas socioeconómicos y políticos. Llegamos a la conclusión de que los impactos de esta crisis llevan la marca de la desigualdad, ya que exponen a la población más pobre a mayores riesgos de contaminación y a la intensificación de las vulnerabilidades sociales. El Estado brasileño ha emprendido una necropolítica, que responde poco a las demandas de estos grupos de población y carga a la clase trabajadora con una cuenta que es estructural del capitalismo.Palabras clave: Pandemia, desigualdad social, terapia ocupacional.