bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Factors Affecting Pregnancy Outcomes in Hypothyroid Women of Pakistan: A Retrospective Study From a Tertiary Center. (MHPO-II)
Authors: Kiran Zareen , Khoja Adeel , Barkat Rahil , Rashid Muhammad Owais , Sheikh Aisha , Islam Najmul 
Published: November 2020

Abstract
Background: Hypothyroidism in pregnancy is known to be associated with adverse outcomes depending on geographical distribution and diagnostic criteria. We analyze the maternal factors affecting pregnancy outcomes in maternal hypothyroidism for the first time in Pakistan.Methods: We conducted a retrospective study on pregnant women attending obstetric clinics during the year 2008-2016. We noted maternal factors such as maternal age, gestational age at antenatal visit, gestational diabetes mellitus, hypertension, and past obstetric history of miscarriages affecting pregnancy loss or live birth in pregnant hypothyroid women as well as normal healthy pregnant women. Odds ratio was calculated using multivariate logistic regression. Subgroup analysis was carried out to compare women with overt versus subclinical hypothyroidism. All data analysis was performed on Stata version 12.Results: Maternal age, gestational age at antenatal visit, gestational diabetes mellitus, hypertension, and past obstetric history of miscarriages were significantly associated with the outcome at the univariate analysis. At multivariable analysis, maternal age, gestational age at the antenatal visit, and past obstetric history of miscarriages were associated with an increased likelihood of pregnancy loss, whereas, gestational diabetes mellitus and hypothyroidism were found to be counter-protective. Subgroup analysis revealed no difference between women those with overt versus subclinical hypothyroidism.Conclusion: We report maternal factors such as age, gestational age at the antenatal visit, and past obstetric history of miscarriages as significant factors affecting adverse pregnancy outcomes in hypothyroidism for the first time from Pakistan.
Depression in Public officials during the COVID-19 Pandemic in Paraguay: A Web-based Study
Authors: Kim Ji Eon , Lee Ji Ho , Kang Yanghee , Lee Sun Ha , Shin Hyein , Rönnebeck Nadia , Rönnebeck Renato , Nam Eun Woo 
Published: November 2020

Abstract
Background: This study investigated the factors influencing depressive feelings in Paraguayan public officials caused by the coronavirus disease (COVID-19) pandemic. Methods: This study used a web-based cross-sectional method to analyze the factors influencing COVID-19-induced depressive feelings in Paraguayan public officials. The study’s research area was Asuncion and Limpio in Paraguay. Results: The results of Model 4 indicated high levels of depressive feelings among public officials, as well as concerns about COVID-19 infection among female public officials. The study also found that public officials’ high levels of depressive feelings were related to the duration of COVID-19 self-quarantine periods. Conclusions: The conclusions drawn from these findings were as follows: First, a targeted intervention program should be developed for female public officials who were found to be more vulnerable to depressive feelings. Second, a program should be developed for people facing deteriorating mental health due to social isolation and loneliness caused by social distancing during prolonged periods of self-quarantine. Third, mental health care programs should be organized in a community-focused way, and online systems should be utilized for more effective mental health recovery.
Mediation Role of Body Fat Distribution (FD) on the Relationship Between CAV-1 rs3807992 Polymorphism and Metabolic Syndrome in Overweight and Obese Women
Authors: Abaj Faezeh , Saeedy Said Abdul Ghafour , Mirzaei Khadijeh 
Published: November 2020

Abstract
Background: Metabolic syndrome (MetS) carries increased risk of the mortality of almost all chronic diseases. The most frequently used methods for calculation of a continuous MetS (cMetS) score have used the MetS severity z- score. Caveolin-1 (CAV-1(is one of the gens that is suggested by some authors that has a great effect on the visceral fat. This study was designed to investigate the relationship between CAV-1 markers and cMetS, the associations between CAV-1 rs3807992 and FD; and to assess FD mediators of the predicted association between CAV-1 and cMetS. Methods: The current cross-sectional study was conducted on 404 overweight and obese females. The CAV-1 rs3807992 and anthropometric data were measured by the PCR-RFLP method and bioelectrical impedance analysis (BIA), respectively. Serum profiles (HDL-C, TG, FPG, and Insulin) were measured by standard protocols. Results: Individuals with GG allele had significantly lowered (Z-MAP (p=0.02), total cMetS (p=0.03)) and higher Z-HDL (p=0.001) compared with A allele carrier. There was a significant specific indirect effect (standardized coefficient = 0.19; 95% CI: 0.01–0.4) of VFL. Although, total body fat was significantly associated with CAV-1 rs3807992 and cMetS, the specific indirect effect was not significant (standardized coefficient = 0.21; 95% CI: (-0.006,0.44). Visceral fat level contributed to significant indirect effects of 35% on the relationship between CAV-1 and cMetS. Conclusion: Higher visceral adipose tissue may affect the relationship between CAV-1 and MetS. Although CAV-1 rs3807992 is linked to visceral fat in our study, the influence of this polymorphism on MetS is not via total fat.
Toxicity and Risk of Plant-Produced Alkaloids to Daphnia magna.
Authors: Griffiths Megan , Strobel Bjarne , Hama Jawameer , Cedergreen Nina 
Published: November 2020

Abstract
Background Many plants contain phytotoxic alkaloids to deter herbivorous pests and grazing animals. Alkaloids include quinolizidine and indole alkaloids found in the lupin (Lupinus spp.), an ornamental flower and emerging protein crop, as well as pyrrolizidine alkaloids in the ragwort (Senecio jacobaea), an invasive, weed-like flower. When lupins and ragworts are present in large densities in fields, there is a concern that alkaloids may leach into freshwater environments in amounts that may affect non-target organisms, such as Daphnia magna. This study aimed to investigate i) the acute toxicity of alkaloids (gramine, heliotrine, lupanine, lupinine, monocrotaline, monocrotaline N-oxide, senecionine and sparteine) in D. magna, ii) the contribution of these individual alkaloids to lupin plant extract toxicity, iii) the longer term reproductive effects of a representative alkaloid, sparteine, and finalise with iv) a tentative risk assessment for the sum of alkaloids measured in soil and surface waters. Results The alkaloids exhibited toxicity, with 48 h EC50 values in the range of 5.6 to >100 mg/L. The 48 h EC50 of the Lupinus angustifolius plant extract was 1.38 mg/L, which was far more toxic than the simulated extract where lethality was <10% at 10 mg/L after 48 h. Hence, non-measured compounds may have contributed to the joint toxicity. Daphnid mothers exposed to >2.5 mg/L sparteine produced significantly fewer and smaller offspring during the 21-day exposure, making chronic effects occur at concentrations approximately 10-fold lower than the 48 h EC50 for sparteine. The risk assessment of cumulated alkaloids measured in drain, running and pond waters showed a potential risk, particularly for stagnant pond water, where concentrations were severalfold higher than in the drain and running waters. Conclusions The results highlight that natural toxins may contribute to poor chemical quality of natural waters, and that natural toxins from upcoming crops or invasive weeds should be considered aquatic in risk assessments.
NT-probnp Variability as a Predictor of Adverse Outcomes in Patients With Cardiorenal Syndrome Type 2
Authors: Ma Mingming , Dong Xiangnan , Cui Shuang , Hocher Berthold , Zeng Shufei , Liang Wenxue , Li Qiang , Chen Xiaoyi , Chen Xin , Meng Yu , Lu Yongping , Yin Lianghong 
Published: November 2020

Abstract
Background: N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is a significant predictor of cardiovascular and all-cause mortality in patients with chronic heart failure (HF) without chronic kidney disease (CKD). However, it is unknown whether variability of NT-proBNP is predictive of the outcomes of those with advanced HF and CKD.Methods: Intra-individual fluctuations in NT-proBNP values from baseline to follow-up were determined to assess the prognostic value of NT-proBNP variability in patients with cardiorenal syndrome (CRS) type 2 in a retrospective cohort of 136 patients treated for advanced HF with CKD at the First Affiliated Hospital of Jinan University from 2012 to 2016. Patients hospitalized for CRS type 2 who underwent follow-up examinations were eligible for study inclusion and grouped according to optimal cutoff values of receiver operating characteristic (ROC) curve analysis of log10(NT-proBNP) variability. The primary outcomes were major adverse renal and cardiac events( a composite of acute kidney disease, nonfatal myocardial infarction, cardiac death ,stroke or maintenance hemodialysis). Secondary outcomes were repeated hospitalization for heart failure or all cause death.Results: The results showed that higher NT-proBNP variability group was associated with lower hemoglobin(p ＜ 0.01) and plasma serum albumin levels(p ＜ 0.02) , and greater decline in left ventricular ejection fraction(p ＜ 0.02 ) compared with the lower NT-proBNP variability group. At a median follow-up of 22 (interquartile range, 5–32) months, Individuals in the higher NT-proBNP variability group was associated with a greater risk of major adverse renal and cardiac events (HR = 3.467, 95% CI =1.463–8.215, p = 0.01). ROC analysis revealed that NT-proBNP variability rather than average NT-proBNP level, was a better predictive biomarker of the primary outcomes (AUC = 0.726,95% CI = 0.640–0.812) and secondary outcomes(AUC = 0.701,95% CI = 0.611–0.791). Kaplan-Meier analysis showed that NT-proBNP variability of ≥0.272 was significantly correlated with a higher prevalence of primary and secondary outcomes (p < 0.03). This correlation remained significant in multivariate Cox regression models after adjustments for age, anemia, and traditional risk factors. Conclusions: NT-proBNP variability might serve as an independent predictor for major adverse renal and cardiac events and all-cause death in patients with CRS type 2.
Experimental, Statistical, and Analytical Evaluation of The Springback Behavior of Martensitic 1400 Sheet in V-Bending
Authors: ŞEN Nuri , SEÇGİN Ömer 
Published: November 2020

Abstract
Ultra-high-strength Martensitic 1400 steel is preferred in the automotive industry because of its high strength as well as its light weight. In this study, Martensitic 1400 steel was subjected to the V-bending process. As a result of 48 different tests, the amount of springback resulting from the V-bending process was determined. A finite element (FE) model was then created based on these experimental data. After it was determined that the experimental results concurred with the FE model, without performing new experiments, further analyses were carried out at different temperatures. Using the results of a total of 96 FE analyses, variance analysis was performed and the effects of the operation parameters on springback were determined. As a result of the study, it was concluded that the most effective parameter on springback in the V-bending process was the die angle and that holding time had no significant effect. It was observed that the springback increased in parallel with the punch radius and die angle and that increases in temperature reduced the springback.
Movement Modeling and Control for Robotic Bonnet Polishing
Authors: LIN Zewen , Wang Zhenzhong , HUANG Xuepeng 
Published: November 2020

Abstract
The spin axis of bonnet tool maintains a constant angle (precession angle) with the normal of polishing point in polishing. In this paper, a controlled model was established on robotic machining platform to polish large diameter axisymmetric aspheric optics. Based on the transformation relationship in spatial coordinate system, the relationships between workpiece coordinate system, polishing point local coordinate system and the bonnet tool coordinate system were set up respectively. So that the movement model of bonnet precession polishing was obtained. What’s more, the efficiency optimal control was added to the movement model. the trajectories and poses of the polishing were determined, and the change of robot linkage angle difference was obtained. Finally, the precession movement model and the control algorithm were verified by the simulation in the Robotstudio, an offline simulation software and experiment for plane component.
Effect of Texture on Energy Consumption for High Frequency Hydraulic Impact Piston Pair
Authors: Mo Hu , Guo Yong , Yanping Hu , Quan Song , Chen Zhewu 
Published: November 2020

Abstract
Limited by the influence of the traditional clearance seal structure on the leakage and friction loss of the piston pair, the energy utilization ratio of the hydraulic impactor is difficult to improve. As such, a novel clearance seal structure with cylindrical texture for the impact piston is proposed to solve it. Considering the leakage and friction loss of impact piston pair, an energy consumption evaluation index is put forward. Based on the average Reynolds equation, an energy consumption analysis model for a textured high-frequency hydraulic impact piston pair is established, and the influence of piston texture parameters for the YG45 hydraulic impactor on energy consumption under rated working conditions is studied. The results show that energy consumption of an impact piston pair accounts for 29.77% of total energy loss. The variation of area ratio textured makes the ratio of energy consumption to the piston pair decline 1.32%~10.98%, where the optimum area rate textured is 0.64 ~ 0.7. The variation of depth ratio textured leads to the reduction of the ratio of energy consumption to piston pair by 3.21% ~ 5.68%, where the optimum depth ratio textured is 1 ~ 1.1.The texture structure of the piston pair significantly reduces the energy consumption of the impact piston pair, and it is an effective approach to avoid the design dilemma for the conventional impact piston pair.
Taylor collocation method for a system of nonlinear Volterra delay integro-differential equations with application to COVID-19 epidemic
Authors: Laib Hafida , Bellour Azzeddine , Boulmerka Aissa 
Published: November 2020

Abstract
The present paper deals with the numerical solution for a general form of a system of nonlinear Volterra delay integro-differential equations (VDIDEs). The main purpose of this work is to provide a current numerical method based on the use of continuous collocation Taylor polynomials for the numerical solution of nonlinear VDIDEs systems. It is shown that this method is convergent. Numerical results will be presented to prove the validity and effectiveness of this convergent algorithm. We apply two models to the COVID-19 epidemic in China and one for the Predator-Prey model in mathematical ecology.
Relationship between Internet use and leaving home during the first wave of the COVID-19 outbreak in Japan
Authors: Yabe Naoto , Hanibuchi Tomoya , Adachi Hiroki M. , Nagata Shohei , Nakaya Tomoki 
Published: November 2020

Abstract
Following the first wave of the COVID-19 outbreak, the Japanese government announced the Declaration of a State of Emergency in April 2020, which aimed to decrease contact between people and requested that residents refrain from leaving home. Even in the absence of penalties, outings decreased under the declaration. We are interested in how outings declined and studied the substitution relationship between Internet use and outings. A web-based survey was conducted to collect data on Internet use and outings in a retrospective manner. The period covered by our data is from mid-February to mid-May 2020. Multilevel analysis and correspondence analysis were performed to examine the relationship between Internet use and outings. The results clearly show that Internet use replaced outings. In particular, Internet use for socializing, exercise, and leisure/entertainment had a significant substitution relationship with outings. In contrast, there was a weak substitution relationship between Internet use for daily shopping and outings. Although telework tends to be an accepted focus of Internet use under the COVID-19 outbreak, it should not be overlooked that other uses of the Internet, such as for leisure/entertainment, also supported the decline in outings.
Role of ROX Index in the first assessment of COVID-19 patients in the Emergency Department
Authors: Gianstefani Alice , Farina Gabriele , Salvatore Veronica , Alvau Francesca , Artesiani Maria Laura , Bonfatti Sara , Campinoti Francesca , Caramella Ilaria , Ciordinik Michele , Lorusso Andrea , Nanni Sara , Nizza Daniela , Nava Stefano , Giostra Fabrizio 
Published: November 2020

Abstract
Background: In Italy, since the first symptomatic cases of Coronavirus disease 2019 (COVID-19) appeared in late February 2020, 205.463 cases of Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) were reported as of April 30, causing an high rate of hospital admission through the Emergency Department (ED).Objectives: The aim of the study was to evaluate the accuracy of ROX index in predicting hospitalization and mortality in patients with suspected diagnosis of COVID-19 in the ED. Secondary outcomes were to assess the number of readmissions and the variations of ROX index between first and second admission.Methods: This is an observational prospective monocentric study, conducted in the ED of Policlinico Sant’Orsola-Malpighi in Bologna. We enrolled 1371 consecutive patients with suspected COVID-19 and ROX index was calculated in 554 patients. Patients were followed until hospital discharge or death. Results: ROX index value < 25.7 was associated with hospitalization (AUC=0.737, 95%CI 0.696–0.779, p<0.001). ROX index < 22.3 is statistically related with higher 30-days mortality (AUC= 0.764, 95%CI 0.708-0.820, p<0.001). 8 patients were discharged and returned in the ED within the following 7 days, their mean ROX index was 30.3 (6.2; range 21.9-39.4) at the first assessment and 24.6 (5.5; 14.5-29.5) at the second assessment, (p=0.012).Conclusion: ROX index, together with laboratory, imaging and clinical findings, can help discriminate patients suspected for COVID-19 requiring hospital admission, their clinical severity and their mortality risk. Furthermore, it can be useful to better manage these patients in territorial healthcare services, especially in the hypothesis of another pandemic.
Liver bacterial dysbiosis occurs in SIV-infected macaques and persists during antiretroviral therapy
Authors: Fisher Bridget S , Fancher Katherine A , Gustin Andrew T , Fisher Cole , Wood Matthew P , Derby Nina , Gale Michael , Burwitz Benjamin J , Smedley Jeremy , Klatt Nichole R , Sodora Donald L 
Published: November 2020

Abstract
Background: Liver disease remains a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful treatment with combination antiretroviral therapy (cART). In non-human primates, SIV infection is associated with gut microbiome dysbiosis as well as bacterial translocation into the colonic lamina propria and liver via the portal vein. Here the liver microbiome was evaluated in rhesus macaques to discern the influence of SIV infection alone (SIV+) and during cART administration (SIV+cART) on liver bacterial dysbiosis and neutrophil infiltration.Results: Dysbiosis in liver bacterial composition was observed, encompassing changes in a number of genera, during SIV infection in the absence and presence of cART. The most striking finding was an increase in the level of Mycobacterium, which while barely detectable in the uninfected macaques, was the most abundant genus observed in the livers of a majority SIV+ and SIV+cART macaques. Multi-gene sequencing analyses identified a species of environmental mycobacteria similar to the opportunistic pathogen M. smegmatis. The effect of M. smegmatis on host gene expression in primary hepatocytes was evaluated in vitro utilizing PILAM, a glycolipid cell wall component found in atypical Mycobacteria. PILAM induced an upregulation of inflammatory responses, including an increase in the chemokines associated with neutrophil chemotaxis (CXCL1, CXCL5, and CXCL6). Assessment of the macaque livers by microscopy determined that neutrophil levels were reduced in SIV+cART macaques, suggesting that the SIV infection and/or cART treatment influence the liver-associated neutrophil response. Conclusions: A number of liver bacteria genera were altered following SIV infection even in the context of cART, possibly as a consequence of reduced neutrophil recruitment. Mycobacteria became a major component of the SIV infected macaque liver microbiome, raising the possibility that bacteria of this genus might contribute to liver disease in HIV infected patients.
Research and Analysis of the Effect of Refined Nursing Intervention on COVID-19 Epidemic in Hemodialysis Center Runing Title:Effect of Refined Nursing Intervention on COVID-19 Epidemic
Authors: Zhang Qinglai , Wang Shuo , Zhang Yue , Meng Fei 
Published: November 2020

Abstract
Background To analyze and discuss the effect of clinical refined nursing intervention on maintenance hemodialysis patients during the outbreak of COVID-19.Methods The Symptom Checklist90 (SCL‑90) was used to conduct nursing interventions before, during and after dialysis for maintenance hemodialysis patients, and the results were compared with the Chinese adult SCL‑90 norm.Results The scores of all factors of SCL-90 in maintenance hemodialysis patients are all higher than normal Chinese SCL-90, and patients with a single factor score greater than or equal to 2 have a higher proportion of depression and anxiety, with extremely significant difference (P < 0.01). The depression and anxiety of the patients were reduced after the intervention, and there was a statistical difference. Two nucleic acid test results of 172 patients were negative.Conclusion During the COVID-19 epidemic, providing maintenance hemodialysis patients with refined nursing intervention can improve their health behavior compliance, regulate negative emotions, reduce related complications, improve their quality of life, and improve the nurse-patient relationship. At the same time, it can fundamentally control the occurrence of nursing errors and adverse events, with outstanding clinical application value.