bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eski Dersim Mebusu Lütfi Fikri Bey'in 1925 Yılında Ankara İstiklal Mahkmesi'nde Yargılanması
Authors: GAZEL Ahmet 
Published: March 2020

II. Abdülhamit, II.
Meşrutiyet ve Atatürk dönemlerinde siyasi faaliyette bulunan Lütfi Fikri Bey,
genelde her dönemde muhalefette yer almış ve zaman zaman da çeşitli
mahkemelerde yargılanmıştır. Lütfi Fikri Bey ilk olarak II. Abdülhamit
döneminde mahkeme önüne çıkmıştır. Mısır’da neşredilen Mizan gazetesine yazı yazmayı teklif ettiği gerekçesiyle 1895
yılında 14 ay hapis cezasına çarptırılmıştır. Lütfi Fikri Bey, ikinci olarak
Halifeliğin kaldırılmasına karşı çıktığı için 1923 yılında İstanbul’da kurulan
İstiklal Mahkemesi’nde yargılanmış ve 27 Aralık 1923 tarihinde İstiklal
Mahkemesince beş yıl ağır hapse mahkûm edilmiştir. Ancak 13 Şubat 1924
tarihinde TBMM tarafından çıkarılan 124 sayılı özel bir yasa ile affedilmiştir. Lütfi Fikri Bey,
1925 yılında ise Ankara İstiklal Mahkemesi’nde yargılanmıştır. Bu seferki
suçlama Tarikat-ı Salahiye adlı gizli bir cemiyete üye olmaktır. Lütfi
Fikri’nin cemiyetle tam bir bağlantısı tespit edilememiştir. Mahkemede bazı
kişilerin adını vermesi ve cemiyet üyelerince 1922 yılında yapılan bir kabine
listesinde yer almış olmasından dolayı evinde arama yapılmıştır. Arama
sırasında cemiyetle bağlantısını gösterecek bir delil bulunamazken abisi Münci
Bey’in yazdığı bir mektup ve 1923 yılına ait günlükleri bulunmuştur. Özellikle günlüğünde
Cumhuriyete ve Mustafa Kemal Paşa’ya yönelik bazı ithamlar tespit edilmiştir.
Neticede tutuklanarak Ankara İstiklal Mahkemesi’ne sevk edilmiştir. 15 Ağustos
1925 tarihinde karar açıklanmış ve cemiyetle bağlantısına dair bir delil
bulunamadığı için Lütfi Fikri Bey beraat etmiştir. Beraat etmesinde cemiyetle
bir bağlantısının tespit edilememesi yanında Mustafa Kemal Paşa’nın Lütfi
Fikri’nin affına dair mahkeme heyetine yazdığı mektup da etkili olmuştur. Bu
makalede Lütfi Fikri Bey’in Tarikat-ı Salahiye Cemiyeti’ne üye olmaktan dolayı
1925 yılında İstiklal Mahkemesinde yargılanması dönemin gazetelerine dayalı
olarak anlatılmıştır.
Imaging Analyses of Bone Tumors
Authors: Errani Costantino , Tsukamoto Shinji , Mavrogenis Andreas F. 
Published: March 2020

» Despite the evolution in imaging, especially the introduction of advanced imaging technologies, radiographs still are the key for the initial assessment of a bone tumor. Important aspects to be considered in radiographs are the location, shape and size or volume, margins, periosteal reaction, and internal mineralization of the tumor’s matrix; careful evaluation of these may provide for accurate diagnosis in >80% of cases.» Computed tomography and magnetic resonance imaging are often diagnostic for lesions with typical findings such as the nidus of osteoid osteoma and bone destruction such as in Ewing sarcoma and lymphoma that may be difficult to detect with radiographs; they may also be used for surgical planning. Magnetic resonance imaging accurately determines the intraosseous extent and articular and vascular involvement by the tumor.» This article summarizes the diagnostic accuracy of imaging analyses in bone tumors and emphasizes the specific radiographic findings for optimal radiographic diagnosis of the patients with these tumors.
Psychological Readiness to Return to Sport Following Anterior Cruciate Ligament Reconstruction
Authors: Ashton Matthew L. , Kraeutler Matthew J. , Brown Symone M. , Mulcahey Mary K. 
Published: March 2020

» Anterior cruciate ligament (ACL) tears are among the most common athletic injuries in the United States, and reconstruction is often necessary for athletes to be able to return to their pre-injury level of sport.» Following ACL reconstruction, many athletes are not able to return to sport.» A number of factors have been identified that could account for the return-to-sport discrepancy; however, psychological readiness can have an important influence on an athlete’s ability to return to sport.» Various interventions aimed at improving psychological factors have shown mixed results, although overall they seem promising.» Sociodemographic factors (e.g., age, sex, and race) appear to have an influence on psychological readiness to return to sport; however, little research has been conducted on this topic.
Feasibility of Electromagnetic Heating for Oil Sand Reservoirs
Authors: Ji Dongqi , Harding Thomas Grant , Chen Zhangxing , Dong Mingzhe , Liu Hui , Li Zhiping , Lai Fengpeng 
Published: March 2020

Abstract
For methods of thermal heavy oil recovery, an alternative approach of applying electrical energy, such as electromagnetic heating, can be used to generate heat in reservoirs that are not suitable for steam injection or to improve the economics and reduce environmental impact of the heavy oil recovery compared to using steam injection. While much progress in the development of electromagnetic heating technology has been made in recent years, the ability to accurately and effectively mathematically model the application of an electromagnetic heating process to a reservoir has been limited. In this paper, based on our reliable and efficient electromagnetic heating simulator, the effects of operational parameters on electromagnetic heating performance are investigated including evaluation of antenna location, well constraints, and applied power and frequency. The feasibility of electromagnetic heating in oil sands reservoirs has been examined for two cases: a) a single horizontal well containing a heating source and b) a horizontal well-pair with heating sources located in both wells.
The Myth of Residual Oil Saturation in SAGD - Simulations Against Reality
Authors: Gupta Subodh , Gittins Simon , Oskouei Javad , Quiroga Samuel , Christiansen Joel 
Published: March 2020

Abstract
Understanding how SAGD works is important as most of the in-situ production of bitumen in Alberta is using SAGD technology. A key parameter in simulation-based SAGD performance prediction is the residual oil saturation, which usually in SAGD simulations is a fixed number based on typical two-phase end-point relative permeability curves, combined with Stone's model to yield oil's relative permeability. Therefore, in simulations residual oil saturation (Sor) never goes below a certain number (typically 0.15-0.2). In reality, based on retrieved cores, there is evidence of Sor continuously decreasing to as low as 0.03 and below. This paper explains the reason for this discrepancy and suggests modifications to the relative permeability model for more realistic simulations.
Observations from retrieved cores suggest the residual oil saturation is dependent on the length of SAGD operation. This is also supported by Cardwell-Parsons correlation albeit for a two-phase system. The discrepancy between the current simulation results and actual observations point to the inadequacy of the relative permeability models containing the end points where krog and krog vanish at abscissas Sw, Sg less than 1. In this work effect of extending mobility of the oil phase all the way to Sw, Sg = 1 and krw, krg all the way to Sw, Sg = 0 is examined. First, a column drainage is numerically simulated, and relevant curve parameters are retrieved by comparing results against field results. These curves are then extended to simulate SAGD.
The results show that the modified relative permeability curves mimic the observed behavior better with residual oil phase saturation progressively decreasing with time, rather than remaining constant after a certain point. Improved correlation with observed saturations obtained using modified curves suggest that the fixed residual saturations resulting from current models are a myth. When extended to solvent aided processes, the model reinforces the benefit of solvent additives even further.
To the best of the authors’ knowledge most current SAGD simulations are done in a manner resulting in a fixed residual oil saturation. The proposed method presents an opportunity for better prediction of oil saturation with time and location and the corresponding performance of the SAGD process.
Does Socioeconomic Status Affect Oral Health? Results from the PERSIAN Cohort Study
Authors: Najafi Farid , Hajizadeh Mohammad , Soofi Moslem , Salimi Yahya , Karyani Ali KAzemi , Soltani Shahin , Ahmadi Sina , Rad Enayatollah Homaie , MAtin Behzad Karami , Pasdar Yahya , Hamzeh Behrooz , Nazar Mehdi Moradi , Mohammadi Ali , Malekzadeh Reza , Poustchi Hossein , Motamed-Gorji Nazgol , Moslem Alireza , Khaleghi Ali Asghar , Fatthi Mohammad Reza , Aghazadeh-Attari Javad , Ahmadi Ali , Pourfarzi Farhad , Somi Mohammad Hossein , Sohrab Mehrnoush , Ansari-Moghadam Alireza , Edjtehadi Farhad , Esmaeili Ali , Joukar Farhad , Lotfi Mohammad Hasan , Aghamolaei Teamur , Eslami Saied , Tabatabaee Seyed Hamid Reza , Saki Nader , Haghdost Ali Akbar , Rezaei Satar 
Published: March 2020

Abstract
The authors have withdrawn this preprint from Research Square.
Generation of human knock-in organoids by CRISPR-HOT
Authors: Artegiani Benedetta , Hendriks Delilah , Clevers Hans 
Published: March 2020

Abstract
This protocol outlines reagents and procedures to generate human knock-in organoids using our established strategy named CRISPR-HOT. The protocol describes the plasmids to be used and strategies to generate knock-in organoids from different organs.
Echocardiography assessment of the left ventricle apical morphology and dynamics in patients with unexplainable deep T-wave inversion and apical wall thickness&lt;15 mm
Authors: Lin Shengnan , Ruan Qinyun , Huang Chunyan , Yan Lei , Fu Liyun , Cai Huang'e 
Published: March 2020

Abstract
Background: There exists a group of patients with the same ECG characteristics as typical apical hypertrophic cardiomyopathy (AHCM) but fails to reach the diagnostic criteria. The objective of this study was to evaluate the apical morphological and dynamical features of this type of patients using echocardiography.Methods:A total of 30 subjects with unexplainable T-wave inversion (TWI) on ECG and apical myocardium thickness <15 mm by echocardiography were recruited. The apical morphological and dynamic features included the left ventricular (LV) apical-to-basal posterior wall thickness ratio (ABR), apical angle (apA) and its percentage change in cardiac cycle, peak blood flow velocity at the apical cavity (Vap) and its ratio to the velocity at LV outflow tract (Vap/VLVOT). The results were compared to those from 32 patients with typical AHCM, 44 with essential hypertension and 43 healthy controls.Results: Compared to healthy controls and hypertension patients, the suspected AHCM group had a significantly higher ABR (1.37±0.23 vs. 0.75±0.08 and 0.75±0.11, P<0.001), lower apAs, higher percent change of apA (74±23% vs. 16±8% and 28±13%, P<0.001) and higher Vap/VLVOT (0.5±0.3 vs. 0.3±0.1 and 0.3±0.1, P<0.05). Patients with typical AHCM had similar apAs and its change and significantly higher ABR (1.85±0.42, P<0.001) and Vap/VLVOT (0.8±0.5, p=0.009) than the suspected AHCM group.Conclusion: Apical morphology and dynamic features of subjects with TWI and LV apical thickness <15 mm were significantly different from healthy controls and hypertension patients, but shared similarities with typical AHCM patients. The results suggest this suspected group may be in an early stage or exhibit a mild phenotype of AHCM. With careful assessment and additional quantitative measurements, it is possible to detect this suspected AHCM group using echocardiography.
Early postpartum oral metoclopramide augments lactogenesis II in insulin-dependent mothers with gestational diabetes: a randomized placebo-controlled trial
Authors: Fok Doris , Chan Yiong Huak , Ho Jiahui , Rauff Mary HJ , Chan Yah Shih , Chong Yap Seng , Mattar Citra NZ 
Published: March 2020

Abstract
Background Mothers with gestational diabetes are at risk of lactogenesis II delayed beyond the third postnatal day and early breastfeeding cessation, which may be overcome by prophylactic intervention. Research aim To evaluate the effect of oral metoclopramide commenced within twelve hours of delivery on lactogenesis II in mothers with insulin-dependent (iGDM) or diet-controlled (dGDM) gestational diabetes. Methods Between July 2006 and January 2009, 73 mothers of term neonates (iGDM, n=20 and dGDM, n=53) were randomized to the metoclopramide (n=37) or placebo groups (n=36). Mothers with gestational diabetes in the intervention group received 30mg of oral metoclopramide daily for the first postnatal week in a randomized double-blinded placebo-controlled study. Primary outcome was lactogenesis II onset by postnatal day 3, while secondary outcomes included expressed human milk volumes (EHM) and exclusive breastfeeding rates and infant weight change.Results 40% more iGDM metoclopramide users achieved lactogenesis II by postnatal day 3 (p=0.01), with 4.8-fold EHM increase over controls (p=0.04); 50% of iGDM mothers perceived lactogenesis II onset by day 2 and more rapid EHM accumulation was observed in all metoclopramide users. Despite this, metoclopramide-users demonstrated less exclusive breastfeeding, earlier cessation and more frequent formula-feeding. Conclusions Short-term metoclopramide uses within the first 12 postnatal hours significantly improved daily EHM production and maternal perception of lactogenesis II onset in iGDM mothers. Treated iGDM mothers did not experience the natural EHM decrease of iGDM placebo-users. The low breastfeeding rate suggested that physiological breastfeeding barriers may not modifiable by metoclopramide or traditional lactation support.
Antimalarial activity of seed extracts of Schinus molle against plasmodium berghei in mice﻿
Authors: Mekuria Abebe Basazn , Geta Mestayet , Birru Eshetie Melese , Gelayee Desalegn Asmelashe 
Published: March 2020

Abstract
Background: Due to drug resistance and inefficient eradication techniques, malaria continues to be a major public health issue in countries with low- and middle-income. The seeds of Schinus molle are used in the Ethiopian folklore medicine for the treatment of malaria. However, this claim is not yet supported with scientific researches. Hence, the current study aims to investigate in vivo, antimalarial activity of hydro-alcoholic crude extract and subsequent solvent fraction of Schinus molle seeds on Plasmodium berghe infected mice.Methods: A hydro-alcoholic crude extract and solvent fractions (ethyl acetate, chloroform and aqueous) of Schinus molle seeds were tested at different doses (100, 200 and 400 mg/kg respectively ) to evaluate in vivo antimalarial activity of extracts in a 4-day suppressive, curative, and prophylaxis antimalarial test models. The parasitemia level, packed cell volume, survival of date, body weight, and body temperature were used to evaluate the anti-plasmodia activity of the extracts. One way ANOVA was employed to analyze these data, followed by post hoc Tukey’s HSD multiple comparison test.Results: The chemo-suppressive activities produced by the highest dose (400mg/kg) of crude extract and the aqueous fraction of Schinus molle seeds in the four-day suppressive test were 76.03% and 73.82%(p<0.001), respectively. In the curative test, the highest dose of crude and the aqueous fraction of Schinus molle seeds had 82.12% and 84.30% (p<0.001) suppression activity, respectively. The percentage of suppression in the prophylactic activities test of the aqueous fraction was 79.78% (p<0.001) at 400mg/kg compared to the negative control group. The studied plant extracts were likely anticipated to show rapid rectal temperature reduction and weight loss significantly. Among the extracts, only chloroform fraction has prevented the reduction of packed cell volume, due to the absence of saponin in the fraction. The mice which were treated with crude extract and aqueous fraction survived longer and gained net body weight as compared to vehicle-treated mice (p<0.001).Conclusion: The crude extract and aqueous fraction of Schinus molle seeds possessed significant antimalarial activity. These results collectively indicate that the plant has promising anti-plasmodial activity against Plasmodium berghei. However, further confirmatory studies followed by isolation and characterization of the active antimalarial compound are recommended.
Benefits of balneotherapy in the management of fibromyalgia syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Cao Chun-Feng , Ma Kun-Long , Li Qian-Lu , Luan Fu-Jun , Wang Qun-Bo , Zhang Ming-Hua , Wang Hai Qiang 
Published: March 2020

Abstract
Objective To assess the effectiveness of balneotherapy (BT) in the management of fibromyalgia syndrome (FMS). Methods The Cochrane Library, EMBASE, MEDLINE, and PubMed were thoroughly searched for relevant studies with a pre-specified searching strategy (from their inception to May 31 st , 2019), to identify randomized controlled trials (RCTs) evaluating BT in FMS management. The primary outcomes were pain, Fibromyalgia Impact Questionnaire (FIQ), Tender Points Count (TPC), Beck’s Depression Index (BDI). A meta-analysis was performed to identify risk ration (RR) or standardized mean difference (SMD) where appropriate, 95%CI with random-effect and consistent models. Results Ten RCT studies with 611 participants were included. Pooled results showed that BT can benefit FMS with significant improvement reflected as, pain (SMD= -0.90, 95%CI [−1.37 to −0.42] I 2 =86%), FIQ (SMD= −0.81, 95% CI [−1.24 to −0.38] I 2 =84%), TPC (SMD= −0.88, 95% CI [−1.63 to −0.14] I 2 =91%) and BDI (SMD= −0.29, 95% CI [−0.53 to −0.05] I 2 =22%) at the end of treatment. However, there was no significant effect on BDI (SMD= −0.57, 95% CI [−1.40 to 0.26]) at follow up. Conclusion Based on 12 to 48 weeks observation, pooled evidence from RCTs indicates BT may reduce pain and improve the quality of life of patients with FMS. Definitive, large-sample studies are needed, with focus on long-term results and maintenance of the beneficial effects.
Core clinical symptoms and heterogeneous manifestations of NS / LAH: three case reports and review of the literature
Authors: zhang qiang , Qin Zailong , Chen Shaoke , Fan Xin 
Published: March 2020

Abstract
Background Noonan-like syndrome with loose anagen hair-a rare autosomal dominant disease with very clinical heterogeneity, is difficult to make clinical diagnosis in the earlier period. We identified the cause of disease with severely short stature by WES on three pediatric cases. Meanwhile, we summarized the clinical manifestations of these three patients and reviewed the literature of the syndrome. Case presentations We finally confirmed three cases of Noonan-like syndrome with loose anagen hair (NS / LAH) (OMIM # 607721) and hotspot mutation in SHOC2 gene (OMIM# 602775), which both involved in the RAS-MAPK signaling pathway. The mutation located in chr10: 112724120, NM_007373.3, c.4A>G (p.Ser2Gly) is de-novo heterozygous in all patients. NS / LAH show some core clinical symptoms, such as craniofacial anomalies, short stature, weight loss, abnormal hair, growth retardation and heterogeneous manifestations (macrocephaly, GH deficiency, congenital heart disease, skin pigmentation, mental retardation, etc.). In the study, we have also proved that it is safe and feasible to apply rhGH treatent on Noonan-like syndrome with loose anagen hair. Conclusions Through our effort, we have identified a rare disease in China. The molecular characteristics, clinical manifestations, and therapeutic measure were summarized so that it can help to clinicians a better understanding of the disease and offer patients effective and timely assistance.
Unresolved atelectasis in refractory Mycoplasma pneumoniae pneumonia: Predictive factors and the influence of corticosteroids and bronchoscopy lavage therapy
Authors: Liu Jianhua , Liu Jinrong , Wang Bei , Liu Yajing , Zhao Chengsong , Zhao Fei , Zhang Jianzhong , Zhao Shunying 
Published: March 2020

Abstract
Background Unresolved atelectasis occurs in some children with refractory mycoplasma pneumoniae pneumonia (RMPP). The aim was to analyze factors predicting unresolved atelectasis in RMPP and the impact of corticosteroids and bronchoscopy lavage therapy (BLT) on developing atelectasis.Methods We retrospectively analyzed data for 230 pediatric RMPP from January 2013 to June 2017 in Beijing Children’s Hospital. In this study, we diagnosed RMPP when patients' clinical and radiological findings deteriorated after 7 days of macrolide therapy, peripheral blood C-reactive protein (CRP) was higher than 40mg/L, and chest imaging showed consolidation with high density > 1/2 pulmonary lobe. We divided patients into two groups according to the presence/absence of atelectasis on chest imaging after a 6-month follow-up. We calculated the predictive value of fever duration, levels of CRP and lactate dehydrogenase (LDH), and the size of lobe consolidation, regarding atelectasis. Additionally, we compared the starting time and dosage of corticosteroids and the starting time of BLT between the two groups.Results Ninety-five patients developed atelectasis (atelectasis group/group A), and 135 patients did not (non-atelectasis group/group NA). Chest imaging showed > 2/3 pulmonary lobe consolidation in 93.7% of patients in group A and 54.1% of patients in group NA. Multiple logistic regression analysis showed that fever duration, CRP and LDH levels, and lobe consolidation were related to developing atelectasis. Areas under the curve revealed that CRP ≥ 137 mg/L had 82.11% sensitivity and 80.07% specificity, and LDH ≥ 471 IU/L had 62.65% sensitivity and 60.31% specificity to predict atelectasis. Fewer patients receiving corticosteroids and BLT within 10 days after illness onset developed atelectasis.Conclusions Fever duration>10 days, CRP and LDH levels, and lobe consolidation are risk factors for developing atelectasis in RMPP. CRP ≥ 137 mg/L, LDH ≥ 471 IU/L, and >2/3 pulmonary lobe consolidation were significant predictors of atelectasis, which can aid in early recognition. Corticosteroid administration and subsequent BLT within 10 days of the disease onset, and increased corticosteroid dosage may help reduce the incidence of atelectasis in these RMPP patients.