bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening Supportive Care Needs, Compliance to Exercise Program, Quality of Life, and Anxiety Level During the COVID-19 Pandemic in Individuals Treated with Hematopoietic Stem Cell Transplantation
Authors: Kabak Vesile Yildiz , Uysal Songul Atasavun , Duger Tulin 
Published: August 2020

Abstract
Purpose: Primary aim was to address supportive care needs, compliance to exercise program, quality of life level (QOL), and anxiety level during the COVID-19 pandemic in individuals treated with hematopoietic stem cell transplantation (HSCT). Secondary aim was to investigate differences in outcome measures in terms of gender and to determine associated factors with supportive care needs and compliance to exercise program during pandemic.Methods: The present study included individuals treated with HSCT and previously consulted to physical therapy. Data were collected by interviewing with participants on phone. Supportive care needs were assessed by using Supportive Care Needs Survey-Short Form 29TR. Compliance to the exercise program was recorded as percentage of walking duration to the recommended duration during the last week. The European Cancer Research and Treatment Organization Quality of Life Questionnaire-Cancer30 was used to assess QOL. The State-Trait Anxiety Inventory-I and Visual Analogue Scale were used to assess anxiety level. Results: Totally 106 individuals were included. The psychological and physical supportive care needs were predominant in participants. Compliance to exercise program was low during the pandemic. Anxiety level was low, yet anxiety about COVID-19 was moderate severity in participants. Supportive care needs were correlated with anxiety level, performance level, duration after HSCT, and QOL (p˂0.05). Compliance to exercise program was associated with performance level and QOL (p˂0.05). Conclusion: Our results offer supportive telehealth interventions should be considered during the COVID-19 pandemic for individuals treated with HSCT to decrease unmet supportive care needs and anxiety, to increase QOL, and to reduce isolation related physical inactivity.
Designing a Paradigm Model for Green Human Resource Management using Data-based Method (Case study on Municipality of Mashhad)
Authors: Janali Mahdi , Kaffashpoor Azar , Rahimpour Amir , Samanian Mosayeb 
Published: August 2020

Abstract
Purpose This paper aims are establishment of management systems such as the Green Human Resource Management System can be effective in achieving the sustainable development and the use of an environmental management system.Design/methodology/approach The research strategy used in this study is the Grounded Theory with Qualitative Research Approach. In order to achieve this goal, a semi-structured interview was conducted in the beginning with human resources experts, including management professors and environment and human resources specialists.Finding Codes of green human resource management in 23 categories including: Green motivation, knowledge, personality, organization, Partnership, Maintenance, compensation, Promotion, Organizational Culture, City, City Council, Rules and Regulations, Government, International Organizations, Suppliers, Media and Green NGOs. Practical implications Management system in urban areas, Prevention with the environmental crisis,Promoting organizational culture in urban planning, Sustainable urban development using green human resources.Social implications A more general implication of the proposed argument for GHRM the concept of "green" has been changed in to a norm and "green actions" refer to activities that not only do not harm the environment, but also improve it. Green human resource management suggests that human resources should be redesigned or re-engineered to be sensitive to laws, policies, resources, proper consumption, non-extravagance, and so on so that they provide optimal and targeted consumption of resources and reduce environmental pollution.Originality/value Designing the model of dimensions of green human resource in 23 categories and in three categories or levels: individual level, organizational level and supra-organizational level.
Congenital Chylothorax in Preterm Infants – A New Approach in Dietary Treatment with Skimmed Breast Milk
Authors: Höck Michaela , Höller Alexander , Hammerl Marlene , Wechselberger Karina , Krösslhuber Jakob , Kiechl-Kohlendorfer Ursula , Scholl-Bürgi Sabine , Karall Daniela 
Published: August 2020

Abstract
BackgroundCongenital chylothorax (CC) is a rare but potentially life-threatening condition in newborns. It is defined as an accumulation of chyle in the pleural cavity. The few publications regarding medical management and therapeutic dietary intervention motivated us to share our experience.MethodsNeonates diagnosed with congenital chylothorax and treated at Innsbruck Medical University Hospital between 2013 and 2019 (n = 5, gestational age: 36 3/7, 32 5/7, 36 4/7, 35 0/7, 35 4/7) were eligible for this report. The cornerstones of treatment for chylothorax conventionally consist of chest tube drainage (CTD), respiratory support, dietary restriction of long-chain triglycerides (LCT) or total parenteral nutrition (TPN). In further course the introduction of a medium-chain triglyceride (MCT)-based formula followed by an overlapping switch to a formula with low LCT and high MCT, containing the essential long-chain fatty acids (LCFA), is attempted. As soon as possible, the change is made to breast milk feeding or breastfeeding. In two patients we used fat-modified (skimmed) breast milk to avoid discontinuation of breast milk feeding.ResultsThe early introduction of LCFA in the form of breast milk after resolution of chylothorax was associated with favourable outcome (no recurrence of pleural effusion and adequate weight gain).ConclusionThe first-line therapy of chylothorax is a combination of respiratory stabilization and dietary modification. The purpose of this report is to point out the feasibility of a fast change from LCT fat-free nutrition to full-fat nutrition once the chylothorax has dissolved, especially the early introduction of breast milk feeding / breastfeeding in infants with chylothorax.
A Novel Ruthenium Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis Via Activating PI3K/Akt/mTOR/VEGF/ MAP Kinase Pathway
Authors: Liang Wei , Shi Junfeng , Xia Haiyan , Wei Xiaowei 
Published: August 2020

Abstract
Background: Breast cancer is the most common cause of malignancy and cancer related morbidity and death worldwide that requests effective and safe chemotherapy. Evaluation of metallo drug based anticancer agents and statins as chemotherapeutics with fewer side effects is largely unexplored research fieldsMethods: The synthesis and characterization of Ruthenium fluvastatin complex was achieved using multiple spectroscopic techniques and thus further examined to evaluate its chemotherapeutic prospects in both MDA-MB-231 and MCF-7 cancer lines and eventually in vivo models of DMBA induced mammary carcinogenesis in rodents. The viability of cells was tested using MTT assay. The apoptotic assay in cell lines was analyzed by flow cytometry. Western blot technique and immunohistochemical approach were used to investigate complex induced signaling pathways. TUNEL assay had predicted in-vivo apoptosis.Results: Our studies indicate that the metal and ligand chelation was materialized by the ligand's functional groups of carbonyl (= O) oxygen and hydroxyl (-OH) and the complex has been observed to be crystalline and able to chelate with CT-DNA. The complex was able to reduce cell proliferation and activate apoptotic events in breast carcinoma cell lines MCF-7 and MDA-MB-231. In addition, the complex was able modify p53 expressions to interfere with apoptosis in the carcinoma of the breast, stimulated by the intrinsic apoptotic path assisted by Bcl2 and Bax, yet at the same point controlling the PI3K / Akt / mTOR pathway correlated with MMP9 regulated tumor mechanisms.Conclusion: Our research reveals that ruthenium-fluvastatin chemotherapy may disrupt, rescind or interrupt breast carcinoma progression by modifying intrinsic apoptosis as well as the antiangiogenic cascade, thereby taking the role of a potential candidate in cancer therapy for the immediate future.
MAZ-LINC00645-GP73 Axis Promotes Hepatocellular Carcinoma Proliferation and Metastasis
Authors: Chen Yang , Li Huiyan , Liu Chunxun , Han Yongmei , Zhang Yubao , Liu Yanlong , Xu Haitao 
Published: August 2020

Abstract
BACKGROUND: Long non-coding RNAs (lncRNA) have been shown to play important roles in the development and progression of hepatocellular carcinoma (HCC). In this report, we examined the role of lncRNA LINC00645 in HCC. MATERIAL AND METHODS: Based on public databases and integrating bioinformatics analyses, the over-expression of LINC00645 in HCC tissues was detected and further validated in a cohort of liver tissues. A series of in vitro and in vivo functional experiments were executed to investigate the role of LINC00645 in the carcinogenesis and development of HCC. Comprehensive transcriptional analysis, chromatin immunoprecipitation (ChIP) assay, dual-luciferase reporter assay and western blot etc. were performed to explore the molecular mechanisms underlying the functions of LINC00645. RESULTS: LINC00645 was significantly upregulated in HCC cell lines and HCC tissues, which was correlated with poor prognosis in HCC patients. LINC00645 knockdown remarkably suppressed tumor growth in vitro and in vivo. Mechanistically, LINC00645 could competitively bind with miR-141-3p to prevent the degradation of its target gene GP73, which acts as a tumor-promoter in HCC. Furthermore, the ChIP assay showed that the transcription factor MAZ could bind to the LINC00645 promoter and increase its transcription. CONCLUSIONS: Collectively, this study demonstrated that LINC00645 plays a critical regulatory role in hepatocellular carcinoma cells and LINC00645 may serve as a potential diagnostic biomarker and therapeutic target of HCC. Thus, targeting MAZ/LINC00645/miR-141-3p/GP73 signaling axis may prevent the progression of HCC.
Managing Urban Solid Waste in Ghana: Perspective and Experiences of Municipal Waste Company Managers and Supervisors in an Urban Municipality
Authors: Lissah Samuel Yaw , Ayanore Martin Amogre , Krugu John K. , Aberese-Ako Matilda , Ruiter Robert A.C. 
Published: August 2020

Abstract
Background: Population growth and rapid urbanization have resulted in the generation of large quantities of solid waste across major urban cities in Ghana, outstripping local authorities’ ability to manage and dispose of waste in a sanitary manner. This study explored the perspectives and experiences of municipal waste company managers and supervisors in the Ho municipality of Ghana on solid waste management practices. Method: A qualitative inquiry was conducted by adopting a phenomenological approach, using in-depth interviews and focus group discussions for data collection. A total of 35 participants, made up of 12 managers and 23 supervisors took part in the study. Transcribed data were imported into NVivo 11.0 software for coding. Content analysis was applied to analyze all transcribed data using processes of induction and deduction. Results are presented using descriptive narratives supported by illustrative quotes. Results: Three themes emerged from the study. The results showed that organizational capacity, resources, and expertise; community factors such as socio-cultural beliefs and a low sense of responsibility towards solid waste management among urban residents; contextual factors such as regulations, and weak enforcement all influence and shape the level of efficiency and effectiveness of solid waste management practices in the study setting. Conclusion: The findings suggest that policy frameworks and procedures implemented should be systematic and thorough in order to tackle the issue of solid waste in the study setting and Ghana in general. The nature of the identified issues and challenges requires multidimensional and multilevel interventions to provide sustainable solutions for managing urban waste in Ghana.
The Impact of COVID-19 on Systemic Anti-Cancer Treatment Delivery in Scotland
Authors: MA Baxter , J Murphy , D Cameron , J Jordan , C Crearie , C Lilley , A Sadozye , M Maclean , P Hall , A Phillips , A Greger , J Madeleine , RD Petty 
Published: August 2020

Abstract
Understanding the impact of the COVID19 pandemic on systemic anti-cancer therapy delivery (SACT) is crucial for a full appreciation of the short and long-term consequences for cancer patients and for planning future cancer care. In this article we report real-time national SACT delivery data from NHS Scotland. We demonstrate an initial rapid reduction in patient attendance for SACT of 28.7% with a subsequent rapid and full recovery following service re-design. Regional variation in the magnitude of impact on SACT delivery was observed, but nadirs occurred at the same time and the rate of recovery was similar across all regions. This recovery reflected a co-ordinated national approach and associated patient and clinician support structures which facilitated the creation of COVID-19 protected areas for SACT delivery in Scottish cancer centres and enabled rapid sharing of successful and innovative strategies. The data shows that these actions have limited the disadvantage to cancer patients.
Deep_Saliency: A Deep Learning based Saliency Approach to detect Covid-19 through x-ray images
Authors: Verma Praveen , Negi Chetan Singh , Pant Maneesh , Saxena Anuj 
Published: August 2020

Abstract
Covid-19 a small virus has created a havoc in the world. The pandemic has already taken over 4 lakh lives. The tests to detect a Covid-19 positive takes time and is costly. Moreover, the ability of the virus to mutate surprises the doctors every day. Present paper proposes a saliency-based model called Deep_Saliency. The model works on chest x-rays of healthy, unhealthy, and covid-19 patients. An x-ray repository of Covid-19, available in public domain, is taken for the study. Deep_Saliency uses visual, disparity, and motion saliency to create a feature dataset of the x-rays. The collected features are tested and trained using Long Short-Term Memory (LSTM) network. A predictive analysis is performed using the x-ray of a new patient to confirm a Covid-19 positive case. The first objective of the paper is to detect Covid-19 positive cases from x-rays. The other objective is to provide a benchmark dataset of biomarkers. The proposed work achieved an accuracy of 96.66%.
Depression, Sexual dysfunction and Quality of Life Among Breast Cancer Patients with Ovarian Function Suppression: A Cross Sectional Study between Ovarian Ablation Verse GnRH Agonists
Authors: Jiang junhan , Xu Junnan , Cai Li , Hu Juan , Man Li , Niu Limin , Sun Tao , Zheng Xinyu 
Published: August 2020

Abstract
Background: Ovarian function suppression is being widely utilized as endocrine therapy to reduce estrogen release in premenopausal breast cancer patients and was achieved either by medical treatment with bilateral oophorectomy, irradiation, or the Gonadotropin releasing hormone (GnRH) agonist. This study aimed to examine whether GnRHa differed from ovarian ablation on depression, sexual dysfunction and quality of life.Methods: The premenopausal breast cancer patients who received ovarian function suppression were enrolled from seven hospital between June 2019 and June 2020. Our independent variable was the type of ovarian suppression, categorized as Ovarian Ablation (OA cohort, n=174) and medical GnRH agonist (GnRHa cohort, n=389). The self-administered questionnaire (OFS-Q5) was developed and used in this study aimed to assess the depression (PHQ-9), sexual dysfunction (FSFI) and quality of life (EORTC QLQ-BR23).Results: In this cross-sectional study, 563 patients with ovarian function suppression completed surveys were collected. The mean sum score of the PHQ-9 tend to be slight decrease in GnRHa cohort than that in ovarian ablation (OA) cohort (11.4 ±5.7 vs. 12.8 ±5.8, OR=1.910, P=0.079). Patients with major depression (PHQ-9≧15) was indicated significantly fewer in GnRHa cohort (31.1% vs 40.2%, P=0.025). The more surprising correlation is less patients with sexual dysfunction (61.5%, FSFI< 23) in OA cohort, a remarkable increase in GnRHa cohort (72.2%, P = 0.011). The ratio of sexual dysfunction remained lower for ovarian ablation women in long-term ovarian suppression (duration of ovarian suppression > 2 years: OA vs GnRHa, OR=1.555, P=0.037). No significantly difference for most subscales of QLQ-BR23 between two cohorts was evident.Conclusions: Our current investigation demonstrate here for the first time that medical GnRHa resulted in favour depression, worse sexual function than those with ovarian ablation, with similar quality of life. This new understanding should help to improve and alleviate adverse effect in patients with diverse ovarian function suppression.
The Increased Levels of Faecal Calprotectin in Children With Active Enthesitis Related Arthritis and Mri Signs of Sacroiliitis: the Results of A Single Centre Cross-Sectional Study in Juvenile Idiopathic Arthritis Patients
Authors: Lamot Lovro , Miler Marijana , Vukojevic Rudolf , Vidovic Mandica , Lamot Mirta , Trutin Ivana , Gabaj Nora Nikolac , Harjacek Miroslav 
Published: August 2020

Abstract
Background: Enthesitis related arthritis (ErA) is a specific subtype of juvenile idiopathic arthritis (JIA) which is often regarded as an undifferentiated form of juvenile spondyloarthritis (jSpA). Beside the arthritis of the peripheral joints, the crucial features of jSpA include enthesitis and/or arthritis of axial joints. Moreover, in adult onset spondyloarthritis gut is increasingly recognized as origin and/or target of inflammation, while the incidence of gut involvement in ErA patients is still largely unknown. The aim of this study was to assess the fCAL concentration, a surrogate marker of gut inflammation, in patients with various subtypes of JIA and non-inflammatory musculoskeletal conditions and to assess the correlation with various demographic, clinical, laboratory, imaging and treatment characteristics.Methods: This was a cross-sectional study involving 71 patients with various forms of JIA and other noninflammatory musculoskeletal diseases (NI-MSD). Along with detailed clinical and laboratory examination, fCAL and magnetic resonance imaging (MRI) of sacroiliac joints, thoracic and lumbar spine was routinely performed in all ErA patients, as well as in other patients who complained of abdominal and/or back pain, respectively. In all JIA patients, disease activity was measured using the juvenile arthritis (JADAS) or spondyloarthritis (jSpADA) disease activity score. Results: The median concentration of fCAL was highest in ErA subgroup (33.2 mg/kg, p=0.043), with a significant difference between patients with inactive and active disease (20.0 mg/kg vs 57.4 mg/kg, p=0.01), as well as between those with or without MRI signs of SIJ inflammation (22.6 mg/kg vs 54.3 mg/kg, p=0.048). In all patients, the fCAL concentration did not significantly differ among those receiving and not receiving NSAIDs (23 mg/kg vs 20 mg/kg, p=0.18), although weak correlation was found with the duration of the use (r=0.25, p=0.03).Conclusion: The (subclinical) gut inflammation might not be present only in adults with SpA, but also in children with undifferentiated forms of the jSpA, especially with active disease and/or MRI signs of SI inflammation.
Histochemical Analysis of Lacrimal Concretions in the Patients using Rebamipide Ophthalmic Suspension
Authors: Yamashita Ken , hiraoka miki , Sugita Shintaro , Yotsuyanagi Takatoshi 
Published: August 2020

Abstract
Backgroud: Concretions of the lacrimal drainage system can cause dacryocystitis. In the present study, our patient developed dacryocystisis with lacrimal concretions of a white soft mass. Rebamipide ophthalmic suspension had been applied for treatment of dry eye. To evaluate the pathogenic mechanism of the case, histological and chemical studies were performed.Case presentation: Our case was woman in her seventies. She had a medical history of rheumatoid arthritis. She was referred to our hospital for dacryocystitis after showing a poor response to treatment with antibiotic agents. A head computed tomography (CT) scan showed ductal high-density deposits along the lacrimal sacs. During dacryocystotomy, the hypertrophy of the lacrimal sacs was found replete with pus and cottage cheese-like white substances. The extracts were surgically removed and histological and chemical analysis was performed. The histological examination showed granulation tissues and acellular amorphous material with crystal-like structures. Positive staining by Alcian blue and Kossa was found in crystal-like legions. The extract obtained from the concretions showed the same fluorescence band and UV absorption spectrum in thin layer chromatography (TLC) and spectrometry, respectively, as rebamipide.Conclusion: Our findings suggest that the obstruction by lacrimal concretions containing rebamipide resulted in dacryocystitis in this case. In addition, it is speculated that in patients who have impaired tear secretion, refractory dacryocystitis may be evoked following the accumulation of rebamipide in the lacrimal sacs.
KIMIE: New Human Breast Milk Pasteurizer-Fully Automated, User Friendly, Cost-Effective Device for Universal Application
Authors: Waghmare Sudhir , Kharche Akshay , Kalane Shilpa , Haridas Vishakha , Patwardhan Sampada , Devaskar Uday 
Published: August 2020

Abstract
Natural mother’s breast milk (MBM) is the best food for all newborns especially the preterm. However, when natural MBM is not available or insufficient donor breast milk (DBM) is the second-best option. Sterifeed or HSC human milk pasteurizers have been commonly used for several decades. While these devices have served the purpose, they are relatively large, expensive, require special electrical and water connections, need a large amount of water which is not recycled and an ongoing supply of disposable plastic bottles. In addition, the use of these machines requires special training. Here we describe the development of a compact, automated, user-friendly human breast milk pasteurizer (HBMP) named Kimie capable of pasteurizing small volumes of DBM. This device does not require special water plumbing, recycles water, is inexpensive and does not require FDA approval.
Aspectos penales del Derecho Ambiental y su vinculación con los Derechos del Consumidor: el caso de los residuos peligrosos
Authors: Yapur María Fernanda , Tambussi Carlos Eduardo 
Published: August 2020

La relación de consumo no se limita a la contratación de bienes y servicios. Comprende también el estudio de los procesos productivos, los insumos utilizados, la producción ambientalmente adecuada y el tratamiento de los desechos. De esa manera, los conceptos de consumo y desarrollo sustentable como valores componentes de derechos humanos fundamentales se complementan mutuamente, como principios que jurídicamente postulan las condiciones para una mejor calidad de vida en el marco de un compromiso respecto de las generaciones futuras relacionado con la conservación del ambiente. Las normas penales respecto a los residuos peligrosos resguardan el ambiente, la salud y la seguridad de los consumidores, contemplando sanciones para determinadas conductas de los proveedores. Un estudio de su contenido, alcance, interpretación y definición de los bienes jurídicos protegidos en el caso del derecho argentino, donde el consumo sustentable es un principio constitucional y legislativo de observación obligatoria por parte de los operadores e intérpretes jurídicos, convierte al derecho penal ambiental en un factor más de protección de los derechos del consumidor.