bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Investigation of Heat Transfer on the Internal Tip Wall in a Rotating Two-Pass Rectangular Channel
Authors: Chia Kai-Chieh , Huang Szu-Chi , Liu Yao-Hsien 
Published: August 2020

Abstract
The tip turn region within the gas turbine blade experienced severe thermal issues related to temperature variations and temperature gradients. The current study experimentally measured the heat transfer distribution of the internal blade tip wall in a rotating cooling channel. The aspect ratio of this rectangular channel was 1:4, and the hydraulic diameter was 25.6 mm. Due to the impact of the 180 deg turn, complex three-dimensional flow significantly affected the heat transfer on the internal tip surface. The steady-state liquid crystal method was used to obtain a detailed distribution of heat transfer on the internal tip surface. In this study, the leading and trailing surfaces of the channel wall were either smooth or roughened with 45 deg angled ribs. The Reynolds number inside the pressurized cooling channel ranged from 10,000 to 30,000, and the rotation number was up to 0.53. Furthermore, two-channel orientations (90 deg and 135 deg) with respect to the rotation direction were tested. The tip heat transfer from the smooth channel wall was more sensitive to rotation, and the largest heat transfer enhancement caused by rotation was 68%. Channel orientation of 90 deg produced higher heat transfer compared to the orientation of 135 deg.
Experimental Validation of a Robust H∞ Control Method on Miniaturized Optical Image Stabilizer Prototypes
Authors: Alizadegan Alireza , Zhao Pan , Nagamune Ryozo , Chiao Mu 
Published: August 2020

Abstract
This paper validates a robust H∞ controller design method, experimentally, on miniaturized prototypes of the magnetically actuated lens-tilting optical image stabilizers (OISs) with product variabilities. Five small-scale OIS prototypes with product variations are constructed by three-dimensional (3D) printing. For the prototypes, the model parameters are identified based on experimental frequency response data of the prototypes. Using the identified model, a robust H∞ controller is designed to guarantee the robust stability of the closed-loop system and to optimize the closed-loop performance. The experimental results reveal larger and more complex uncertainties in miniaturized OISs with mass-produced parts compared to large-scale prototypes. Despite the increased amount of uncertainties, it is demonstrated that the robust H∞ controller still outperforms the conventional controllers in terms of robust closed-loop stability, performance, and controller order for practical implementation on a mobile phone device.
Critical COVID-19 patient evacuation on an amphibious assault ship: feasibility and safety. A case series
Authors: Nguyen Cédric , Montcriol A , Janvier F , Cungi P-J , Esnault P , Mathais Q , Vallet C , Boussen S , Cordier P-Y , Serpin L , Papazian L , Bordes J 
Published: August 2020

IntroductionAn amphibious assault ship was deployed on 22 March in Corsica to carry out medical evacuation of 12 critical patients infected with COVID-19. The ship has on-board hospital capacity and is the first time that an amphibious assault ship is engaged in this particular condition. The aim is to evaluate the feasibility and safety of prolonged medical evacuation of critical patients with COVID-19.MethodsWe included 12 patients with confirmed COVID-19 infection: six ventilated patients with acute respiratory distress syndrome and six non-ventilated patients with hypoxaemia. Transfer on an amphibious assault ship lasted 20 hours. We collected patients’ medical records: age, comorbidities, COVID-19 history and diagnosis, ventilation supply and ventilator settings, and blood gas results. We calculated oxygen consumption (OC).ResultsAll patients had a medical history. The median delay from onset of symptoms to hospitalisation was 8 (7–10) days. The median Sequential Organ Failure Assessment score on admission was 3 (2–5). There was no significant increase in oxygen during ship transport and no major respiratory complication. There was no significant increase in arterial oxygen pressure to fractional inspired oxygen ratio among ventilated patients during ship transport. Among ventilated patients, the median calculated OC was 255 L (222–281) by hours and 5270 L (4908–5616) during all ship transport. Among non-ventilated patients, the median calculated OC was 120 L (120–480) by hours and 2400 L (2400–9600) during all ship transport.ConclusionThe present work contributes to assessing the feasibility and safety condition of critical COVID-19 evacuation on an amphibious assault ship during an extended transport. The ship needs to prepare a plan and a specialised intensive team and conduct patient screening for prolonged interhospital transfers.
Value of FEops HEARTguide patient-specific computational simulations in the planning of left atrial appendage closure with the Amplatzer Amulet closure device: rationale and design of the PREDICT-LAA study
Authors: Garot Philippe , Iriart Xavier , Aminian Adel , Kefer Joelle , Freixa Xavier , Cruz-Gonzalez Ignacio , Berti Sergio , Rosseel Liesbeth , Ibrahim Reda , Korsholm Kasper , Odenstedt Jacob , Nielsen-Kudsk Jens-Erik , Saw Jaqueline , Sondergaard Lars , De Backer Ole 
Published: August 2020

BackgroundOptimal preprocedural planning is essential to ensure successful device closure of the left atrial appendage (LAA).DesignThe PREDICT-LAA study is a prospective, international, multicentre, randomised controlled trial (ClinicalTrials.govNCT04180605). Two hundred patients eligible for LAA closure with an Amplatzer Amulet device (Abbott, USA) will be enrolled in the study. Patients will be allocated to a computational simulation arm (experimental) or standard treatment arm (control) using a 1:1 randomisation. For patients randomised to the computational simulation arm, preprocedural planning will be based on the analysis of cardiac computed tomography (CCT)-based patient-specific computational simulations (FEops HEARTguide, Ghent, Belgium) in order to predict optimal device size and position. For patients in the control arm, preprocedural planning will be based on local practice including CCT analysis. The LAA closure procedure and postprocedural antithrombotic therapy will follow local practice in both arms. The primary endpoint of the study is incomplete LAA closure and device-related thrombus as assessed at 3 months postprocedural CCT. Secondary endpoints encompass procedural efficiency (number of devices used, number of repositioning, procedural time, radiation exposure, contrast dye), procedure-related complications within 7 days postprocedure and a composite of all-cause death and thromboembolic events at 12 months.ConclusionThe objective of the PREDICT-LAA study is to test the hypothesis that a preprocedural planning for LAA closure with the Amplatzer Amulet device based on patient-specific computational simulations can result in a more efficient procedure, optimised procedural outcomes and better clinical outcomes as compared with a standard preprocedural planning.Trial registration numberClinicalTrials.gov Registry (NCT04180605).
Extending trinity to the scalar sector through discrete flavoured symmetries
Authors: Alves João M. , Botella Francisco J. , Branco Gustavo C. , Nebot Miguel 
Published: August 2020

AbstractWe conjecture the existence of a relation between elementary scalars and fermions, making it plausible the existence of three Higgs doublets. We introduce a Trinity Principle (TP) which, given the fact that there are no massless quarks, requires the existence of a minimum of three Higgs doublets. The TP states that each row of the mass matrix of a quark of a given charge should receive the contribution from one and only one scalar doublet and furthermore a given scalar doublet should contribute to one and only one row of the mass matrix of a quark of a given charge. This principle is analogous to the Natural Flavour Conservation (NFC) of Glashow and Weinberg with the key distinction that NFC required the introduction of a flavour blind symmetry, while the TP requires a flavoured symmetry, to be implemented in a natural way. We provide two examples which satisfy the Trinity Principle based on $${\mathbb {Z}}_3$$Z3 and $${\mathbb {Z}}_2\times {\mathbb {Z}}_2'$$Z2×Z2′ flavoured symmetries, and show that they are the minimal multi-Higgs extensions of the Standard Model where CP can be imposed as a symmetry of the full Lagrangian and broken by the vacuum, without requiring soft-breaking terms. We show that the vacuum phases are sufficient to generate a complex CKM matrix, in agreement with experiment. The above mentioned flavoured symmetries lead to a strong reduction in the number of parameters in the Yukawa interactions, enabling a control of the Scalar Flavour Changing Neutral Couplings (SFCNC). We analyse some of the other physical implications of the two models, including an estimate of the enhancement of the Baryon Asymmetry of the Universe provided by the new sources of CP violation, and a discussion of the strength of their tree-level SFCNC.
Differential and difference equations for recurrence coefficients of orthogonal polynomials with hypergeometric weights and Bäcklund transformations of the sixth Painlevé equation
Authors: Hu Jie , Filipuk Galina , Chen Yang 
Published: August 2020

It is known from [G. Filipuk and W. Van Assche, Discrete orthogonal polynomials with hypergeometric weights and Painlevé VI, Symmetry Integr. Geom. Methods Appl. 14 (2018), Article ID: 088, 19 pp.] that the recurrence coefficients of discrete orthogonal polynomials on the nonnegative integers with hypergeometric weights satisfy a system of nonlinear difference equations. There is also a connection to the solutions of the [Formula: see text]-form of the sixth Painlevé equation (one of the parameters of the weights being the independent variable in the differential equation) [G. Filipuk and W. Van Assche, Discrete orthogonal polynomials with hypergeometric weights and Painlevé VI, Symmetry Integr. Geom. Methods Appl. 14 (2018), Article ID: 088, 19 pp.]. In this paper, we derive a second-order nonlinear difference equation from the system and present explicit formulas showing how this difference equation arises from the Bäcklund transformations of the sixth Painlevé equation. We also present an alternative way to derive the connection between the recurrence coefficients and the solutions of the sixth Painlevé equation.
Multimodal Analgesia and Decreased Opioid Use in Adult Trauma Patients
Authors: Drahos Andrew L. , Scott Anthony M. , Johns Tracy J. , Ashley Dennis W. 
Published: August 2020

Background There is an opioid epidemic in the United States. With the increased concern of over-prescribing opioids, physicians are seeking alternative pain management strategies. The purpose of this study is to review the impact of instituting a multimodal analgesia (MMA) guideline on decreasing opioid use in trauma patients at a Level 1 trauma center. Methods In 2017, an MMA guideline was developed and included anti-inflammatories, muscle relaxants, neuropathic agents, and local analgesics in addition to opioids. Staff were educated and the guideline was implemented. A retrospective review of medications prescribed to patients admitted from 2016 through 2018 was performed. Patients admitted in 2016 served as the control group (before MMA). In 2018, all patients received multimodal pain therapy as standard practice, and served as the comparison group. Results A total of 10 340 patients were admitted to the trauma service from 2016 through 2018. There were 3013 and 3249 patients for review in 2016 and 2018, respectively. Total morphine milligram equivalents were 2 402 329 and 1 975 935 in 2016 and 2018, respectively, a 17.7% decrease ( P < .001). Concurrently, there was a statistically significant increase in the use of multimodal pain medications. A secondary endpoint was studied to evaluate for changes in acute kidney injury; there was not a statistically significant increase (0.56% versus 0.68%, P = .55). Discussion Implementation of an MMA guideline significantly reduced opioid use in trauma patients. The use of nonopioid MMA medications increased without an increased incidence of acute kidney injury.
The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study
Authors: Bloomfield Michael A P , Green Sebastian F , Hindocha Chandni , Yamamori Yumeya , Yim Jocelyn Lok Ling , Jones Augustus P M , Walker Hannah R , Tokarczuk Pawel , Statton Ben , Howes Oliver D , Curran H Valerie , Freeman Tom P 
Published: August 2020

Background: Cannabidiol (CBD) is being investigated as a potential treatment for several medical indications, many of which are characterised by altered memory processing. However, the mechanisms underlying these effects are unclear. Aims: Our primary aim was to investigate how CBD influences cerebral blood flow (CBF) in regions involved in memory processing. Our secondary aim was to determine if the effects of CBD on CBF were associated with differences in working and episodic memory task performance. Methods: We used a randomised, crossover, double-blind design in which 15 healthy participants were administered 600 mg oral CBD or placebo on separate days. We measured regional CBF at rest using arterial spin labelling 3 h after drug ingestion. We assessed working memory with the digit span (forward, backward) and n-back (0-back, 1-back, 2-back) tasks, and we used a prose recall task (immediate and delayed) to assess episodic memory. Results: CBD increased CBF in the hippocampus (mean (95% confidence intervals) = 15.00 (5.78–24.21) mL/100 g/min, t14 = 3.489, Cohen’s d = 0.75, p = 0.004). There were no differences in memory task performance, but there was a significant correlation whereby greater CBD-induced increases in orbitofrontal CBF were associated with reduced reaction time on the 2-back working memory task ( r= −0.73, p = 0.005). Conclusions: These findings suggest that CBD increases CBF to key regions involved in memory processing, particularly the hippocampus. These results identify potential mechanisms of CBD for a range of conditions associated with altered memory processing, including Alzheimer’s disease, schizophrenia, post-traumatic stress disorder and cannabis-use disorders.
Circulating IGFBP-2 levels are inversely associated with the incidence of nonalcoholic fatty liver disease: A cohort study
Authors: Yang Ji , Zhou Wenjing , Wu Yue , Xu Liqian , Wang Yuming , Xu Zherong , Yang Yunmei 
Published: August 2020

Objective The insulin-like growth factor (IGF) axis is essential for the body’s metabolism. The hepatokine, insulin-like growth factor-binding protein 2 (IGFBP-2), acts as a major regulator of this metabolism. We aimed to evaluate the role of serum IGFBP-2 in the incidence of nonalcoholic fatty liver disease (NAFLD). Methods This hospital-based prospective cohort study recruited residents from a health program from January to November 2013, and re-invited them for follow-up in 2016. The occurrence of NAFLD was noted and IGFBP-2 levels were evaluated by enzyme-linked immunosorbent assay at both visits. Results Of 763 participants at baseline, 296 completed the re-evaluation. Baseline serum IGFBP-2 levels were significantly lower in subjects with NAFLD compared with those without NAFLD. Circulating IGFBP-2 levels were negatively correlated with body mass index, waist-to-hip ratio, alanine transaminase, triglycerides, fasting glucose, and insulin. IGFBP-2 levels at follow-up decreased in subjects who developed NAFLD compared with those who did not. Higher circulating levels of IGFBP-2 at baseline were negatively associated with the incidence of NAFLD. Conclusion These results indicate that IGFBP-2 levels are inversely associated with the risk of NAFLD. This offers new insights into the role of circulating IGFBP-2, as an IGF-axis hepatokine, in the pathogenesis of hepatic steatosis.
A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels
Authors: Yuan Bo , Pi Ya-Lei , Zhang Ya-Nan , Xing Peng , Chong He-Meng , Zhang Hui-Feng 
Published: August 2020

Objective To establish a diagnostic model of idiopathic central precocious puberty on the basis of transrectal pelvic ultrasound and basal gonadotropin. Methods A total of 669 girls with Tanner breast development stage II were enrolled in this study from January 2015 to December 2018. The participants were divided into the ICPP group and the premature thelarche group. We analyzed various variables, including age at initial diagnosis, basal luteinizing hormone levels, the long diameter of the uterus, the transverse diameter of the uterus, the anterior–posterior diameter of the uterus, the volume of the uterus, maximum ovarian diameter, average ovarian volume, maximum ovarian volume, number of follicles (≥4 mm), maximum follicular diameter, endometrial thickness, and vaginal wall thickness. Results The following diagnostic model was established: Y=−14.123 + 0.630 × age at initial diagnosis + 1.119 × transverse diameter of the uterus + 1.278 ×  anterior–posterior diameter of the uterus + 0.637 × average ovarian volume + 1.316 × maximum ovarian diameter + 0.146 ×number of follicles ≥4 mm + 2.925 × endometrial thickness + 0.559 × basal luteinizing hormone value. The area under curve was 0.922, sensitivity was 84.9%, and specificity was 86.2%. Conclusion Basal LH levels and transrectal pelvic ultrasound should be applied together to improve the accuracy of diagnosis in ICPP.
Management of bleeding associated with radiofrequency ablation of benign thyroid nodules
Authors: Hu Kunpeng , Lian Yufan , Wang Jinfen , Li Wenchao , Yao Zhicheng , Liu Bo , Ren Jie 
Published: August 2020

Objective This study was performed to explore the effective management of bleeding associated with radiofrequency ablation (RFA) of benign thyroid nodules. Methods Thirty-five patients with benign thyroid nodules who were treated with ultrasound-guided RFA from July 2015 to December 2016 at the Third Affiliated Hospital of Sun Yat-sen University were retrospectively reviewed. The technique efficacy, bleeding, and other complications were assessed during the follow-up period. Results The mean technique efficacy was 55.6%±22.8% at 1 month and 24.1%±17.1% at 6 months after the procedure. One case of an intranodular haematoma and two cases of voice change (>1 month) were observed. All patients recovered with corresponding treatment. Conclusion Although the incidence of haemorrhage is low, serious haematomas are life-threatening. Therefore, having a comprehensive understanding of the potential complications, an accurate clinical strategy, and adequate technical skills may prevent or help to properly manage these complications.
Disease Progression in Frontotemporal Dementia and Alzheimer Disease: The Contribution of Staging Scales
Authors: Lima-Silva Thaís Bento , Mioshi Eneida , Bahia Valéria Santoro , Cecchini Mário Amore , Cassimiro Luciana , Guimarães Henrique Cerqueira , Gambogi Leandro Boson , Caramelli Paulo , Balthazar Márcio , Damasceno Benito , Brucki Sônia M. D. , de Souza Leonardo Cruz , Nitrini Ricardo , Yassuda Mônica Sanches 
Published: August 2020

Introduction: There is a shortage of validated instruments to estimate disease progression in frontotemporal dementia (FTD). Objectives: To evaluate the ability of the FTD Rating Scale (FTD-FRS) to detect functional and behavioral changes in patients diagnosed with the behavioral variant of FTD (bvFTD), primary progressive aphasia (PPA), and Alzheimer disease (AD) after 12 months of the initial evaluation, compared to the Clinical Dementia Rating scale−frontotemporal lobar degeneration (CDR-FTLD) and the original Clinical Dementia Rating scale (CDR). Methods: The sample consisted of 70 individuals, aged 40+ years, with at least 2 years of schooling, 31 with the diagnosis of bvFTD, 12 with PPA (8 with semantic variant and 4 with non-fluent variant), and 27 with AD. The FTD-FRS, the CDR, and the 2 additional CDR-FTLD items were completed by a clinician, based on the information provided by the caregiver with frequent contact with the patient. The Addenbrooke Cognitive Examination-Revised was completed by patients. After 12 months, the same protocol was applied. Results: The FTD-FRS, CDR-FTLD, and CDR detected significant decline after 12 months in the 3 clinical groups (exception: FTD-FRS for PPA). The CDR was less sensitive to severe disease stages. Conclusions: The FTD-FRS and the CDR-FTLD are especially useful tools for dementia staging in AD and in the FTD spectrum.
Classical Hodgkin lymphoma-like post-transplant lymphoproliferative disease after allogeneic stem cell transplantation for primary myelofibrosis is successfully treated with nivolumab: A case report
Authors: Gunes Ahmet K. , Demir Ilknur , Pehlivan Mustafa 
Published: August 2020

Introduction Post-transplant lymphoproliferative disease (PTLD), a lymphoid proliferation observed after the solid organ transplantation or allogeneic stem cell transplant, is an important and mortal complication that can occur during the post-transplant period. Classical Hodgkin lymphoma-like PTLD is the least form of PTLD. We are presenting an adult case of classical Hodgkin lymphoma-like PTLD which was successfully treated with nivolumab. Case report A 31-year-old female was diagnosed with primary myelofibrosis and we performed allogeneic stem cell transplantation from her HLA fully matched brother in 2015. Two years after transplant, classical Hodgkin lymphoma-like PTLD was diagnosed. The patient was resistant to six cycles of ABVD chemotherapy and four cycles of brentuximab vedotin. Management and outcome After the failure of ABVD and brentuximab vedotin, we started nivolumab therapy at a dose of 3 mg/kg every 2 weeks. After six cycles, we achieved a PET negative complete remission. After 10 cycles of nivolumab, the patient is still followed with a complete remission. Still, there is no evidence of acute or chronic GvHD, and therefore no need for immunosuppressive treatment. No auto-immune complication was observed. It is planned to give nivolumab treatment to the patient until the progression. Discussion Our case has depicted that the classical Hodgkin lymphoma type PTLD may be resistant to the conventional treatments and anti-CD30 brentuximab vedotine. In such cases, nivolumab may be an effective and worth assessing agent in terms of both activity and safety profile.