bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displacement-mediated bound states in the continuum in all-dielectric superlattice metasurfaces
Authors: Shi Tan , Deng Zilan , Tu Qing-An , Cao Yaoyu , Li Xiangping 
Published: January 2021

Abstract
Bound states in the continuum (BICs) are localized states coexisting with extended waves inside the continuous spectrum range, which have infinite lifetimes without any radiation. To extract high-Q quasi-BIC resonances from the symmetry-protected BIC for practical applications, symmetry-breaking approaches are usually exploited, either by slightly breaking the excitation field symmetry or structure symmetry. Here, we introduce an all-dielectric superlattice metasurface that can symmetry-compatibly convert BIC states into high-Q quasi-BIC modes based on the guided-mode resonance coupling by relative displacement tuning. The metasurface is composed of a superlattice of multiple nanobeams, supporting both magnetic mode and toroidal mode with large tunability. Both modes can interact with the incident continuum by mediating the displacement between nanobeams, which empowers dual asymmetric Fano resonances with high Q-factors. The bandwidth of the toroidal mode under TE-polarized incidences and that of the magnetic mode under TM-polarized incidences can be readily tuned by the local displacement between nanobeams in each unit cell. Such displacement-mediated BIC resonance is promising for various applications such as bio-molecule sensing and low threshold lasing.
Undergraduate Medical Education in Bangladesh during Coronavirus Disease 2019: Scope and Limitations
Authors: Parveen Mosammat Kohinoor , Hannan Md Jafrul , Hasan Md Samiul , Nandy Alak 
Published: January 2021

Abstract
Background: COVID-19 has highly impacted the education system and has created trends in online classes. To fill in the gap created by lockdown and to continue the uninterrupted learning process, educational institutions worldwide started organizing online classes. Although medical education is mostly practical, it is not safe to conduct on campus classes. This study aimed to measure the scope and limitations of online education and the overall impact of COVID-19 on the medical education system.Methodology: This was a cross-sectional study. Ethical approval was obtained from the ethical committee of the South Point Hospital. Informed consent was obtained. Self-administered questionnaires were administered to participants.Results: E-Learning opportunities were made available in 98.69% of cases; some student forums also participated. Among survey respondents, females predominated (57.39%), and 42% of respondents belonged to rural areas and small towns. Access and quality of internet during online classes was average to poor in 54%, and only 10% said it was good. Zoom was the platform for classes in 98% of situations, followed by Facebook live (41.05%), prerecorded video upload, YouTube link, etc. Sixty percent graded the quality of online classes as good, 10% excellent, and 5% bad. Approximately 43% of the participants evaluated online assessments as good. Of the respondents, 17% faced substantial stress, and 18% did not. Twenty-eight percent of the students faced huge mental stress during COVID-19.Conclusions: E-learning is a new normal during the COVID-19 pandemic. Given the opportunity, medical students benefited greatly, but there was a technological divide. There were also financial and mental stresses to a certain extent.
DeepGRN: Prediction of transcription factor binding site across cell-types using attention-based deep neural networks&nbsp;
Authors: Chen Chen , Hou Jie , Shi Xiaowen , Yang Hua , Birchler James A. , Cheng Jianlin 
Published: January 2021

Abstract
BackgroundDue to the complexity of the biological systems, the prediction of the potential DNA binding sites for transcription factors remains a difficult problem in computational biology. Genomic DNA sequences and experimental results from parallel sequencing provide available information about the affinity and accessibility of genome and are commonly used features in binding sites prediction. The attention mechanism in deep learning has shown its capability to learn long-range dependencies from sequential data, such as sentences and voices. Until now, no study has applied this approach in binding site inference from massively parallel sequencing data. The successful applications of attention mechanism in similar input contexts motivate us to build and test new methods that can accurately determine the binding sites of transcription factors.ResultsIn this study, we propose a novel tool (named DeepGRN) for transcription factors binding site prediction based on the combination of two components: single attention module and pairwise attention module. The performance of our methods is evaluated on the ENCODE-DREAM in vivo Transcription Factor Binding Site Prediction Challenge datasets. The results show that DeepGRN achieves higher unified scores in 6 of 13 targets than any of the top four methods in the DREAM challenge. We also demonstrate that the attention weights learned by the model are correlated with potential informative inputs, such as DNase-Seq coverage and motifs, which provide possible explanations for the predictive improvements in DeepGRN.ConclusionsDeepGRN can automatically and effectively predict transcription factor binding sites from DNA sequences and DNase-Seq coverage. Furthermore, the visualization techniques we developed for the attention modules help to interpret how critical patterns from different types of input features are recognized by our model.
Heparin-induced thrombocytopenia presenting as splenic hemorrhage following cardiac surgery: a case report
Authors: Ferry Joseph F. , Youssef Samuel , Wu Pierce , Hegerova Livia 
Published: January 2021

Abstract
Background: Heparin-induced thrombocytopenia with thrombosis (HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT presenting as thrombocytopenia with or without thrombosis within 5-10 days of heparin exposure. Thrombotic complications associated with HIT carry a mortality rate of 5-10%. Case presentation: We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as the main indicator of HIT following cardiac surgery in a 62-year-old woman. She presented to the emergency department on day nine following coronary artery bypass graft surgery with acute weakness, dizziness, and malaise. Her evaluation in the emergency department found anemia and thrombocytopenia. A coagulation profile revealed a markedly elevated d-dimer. She underwent a computed tomography scan of the chest, abdomen and pelvis for suspected bleed and was found to have splenic vein thrombosis, right atrial filling defects consistent with atrial thrombus and mild to moderate hemoperitoneum. Surgical consultation was obtained due to splenic hemorrhage. Hematology was consulted on post-operative day 10, however, she unfortunately developed left sided weakness concerning for stroke. A magnetic resonance imaging scan of the brain demonstrated infarct involving distribution of the right anterior cerebral artery. A transesophageal echocardiogram demonstrated a large immobile thrombus within the right atrium with a second, mobile thrombus arising from the left tricuspid valve annulus. Due to a 4Ts score of 7 and markedly positive platelet factor 4 (PF4) IgG antibody a serotonin release assay was not performed given the high probability of HIT. She was cautiously treated with bivalirudin and was transitioned to warfarin anticoagulation. In the following days her platelet count recovered and 3 months later a transthoracic echocardiogram revealed solution of the intracardiac thrombi. Conclusions: Atraumatic splenic hemorrhage is an unusual presentation of HIT that is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that also occurs in HIT. Alternative anticoagulation is the mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability. Despite similarities of the presentation between splenic hemorrhage and bilateral adrenal hemorrhage, splenic hemorrhage is rarely described in the literature. HIT should be considered in patients presenting with thrombocytopenia following cardiac surgery.
Improved dynamics of sharing research findings in the COVID-19 epidemic compared with the SARS and Ebola epidemics
Authors: Khanali Javad , Malekpour Mohammad-Reza , Kolahi Ali-Asghar 
Published: January 2021

Abstract
Background: When a new or re-emergent pathogen, such as SARS-CoV-2, causes a major outbreak, rapid access to pertinent research findings is crucial for planning strategies and decision making. We researched whether the speed of sharing research results in the COVID-19 epidemic was higher than the SARS and Ebola epidemics. We also researched whether there is any difference in the most frequent topics investigated before and after the COVID-19, SARS, and Ebola epidemics started. Methods: We used PubMed database search tools to determine the time-period it took for the number of articles to rise after the epidemics started and the most frequent topics assigned to the articles.Results: The main results were, first, the rise in the number of articles occurred six weeks after the COVID-19 epidemic started whereas, this rise occurred five months after the SARS and seven months after the Ebola epidemics started. Second, etiology, statistics & numerical data, and epidemiology were the three most frequent topics investigated in the COVID-19 epidemic. However, etiology, microbiology, and genetics in the SARS epidemic, and statistics & numerical data, epidemiology, and prevention & control in the Ebola epidemic were more frequently studied compared with other topics. Third, some topics were studied more frequently after the epidemics started.Conclusions: The speed of sharing results in the COVID-19 epidemic was much higher than the SARS and Ebola epidemics, and that there is a difference in the most frequent articles’ topics investigated in these three epidemics. Due to the value of time in controlling epidemics spread, the study highlights the necessity of defining more solutions for rapidly providing pertinent research findings in fighting against the next public health emergency.
Population migration, spread of COVID-19, and epidemic prevention and control: empirical evidence from China
Authors: Hu Zhen , Wu Yuanyang , Su Mohan , Xie Lin , Zhang Anqi , Lin Xueyu , Nie Yafeng 
Published: January 2021

Abstract
Background: This study applied the SEIR model to analyze and simulate the transmission mechanisms of the coronavirus disease 2019 (COVID-19) in China. Methods: The population migration was embedded in the SEIR model to simulate and analyze the effects of the amount of population inflow on the number of confirmed cases. Based on numerical simulations, this study used statistical data for the empirical validation of its theoretical deductions and discussed how to improve the effectiveness of epidemic prevention and control considering population migration variables. Statistics regarding the numbers of infected people in various provinces were obtained from the epidemic-related data reported by China’s National Health Commission. Results: This study explored how the epidemic should be prevented and controlled from the perspective of population migration variables. It found that a combination of a susceptible population, an infected population, and transmission media was an important route affecting the number of infections and that the migration of a Hubei-related infected population played a key role in promoting epidemic spread. Epidemic prevention and control should focus on regions with better economic conditions than the epidemic region. Prevention and control efforts should focus on the more populated neighboring provinces having convenient transportation links with the epidemic region. To prevent and control epidemic spread, priority should be given to elucidating the destinations and directions of population migration from the domestic origin of infections, and then stemming population migration or human-to-human contact after such migration. Conclusions: This study enriched and expanded on simulations of the effects of population migration on the COVID-19 epidemic and China-based empirical studies while offering an epidemic evaluation and warning mechanism to prevent and control similar public health emergencies in the future.
Developing a Comprehensive School-Based Physical Activity Program with Flexible Design – From Pilot to National Program
Authors: Mooses Kerli , Vihalemm Triin , Uibu Marko , Mägi Katrin , Korp Leene , Kalma Maarja , Mäestu Evelin , Kull Merike 
Published: January 2021

Abstract
This article focuses on the process of designing the vital, participatory school-based intervention program aiming to increase the physical activity in schools. The program analyzed is Estonian nationwide comprehensive physical activity program Schools in Motion (SiM) that recently received European Commission’s #BeActive Education Award. The program has a good performance in terms of willingness of schools to participate in co-creation of program development, the high interest to join the program and zero dropouts, and strong partnership with ministries which enables to actively participate in policy making. Authors analyze the key elements of the planning, piloting, implementation, and scaling phases of the SiM program and share their lessons learnt in co-working with schools. The difficulties faced during the development process, the strengths and challenges associated with an interdisciplinary approach, and involvement of schools as experts have been addressed.
Electronic Reporting of Integrated Disease Surveillance and Response: Lessons learned from Northeast, Nigeria, 2019.
Authors: Ibrahim Luka Mangveep , Okudo Ifeanyi , Stephen Mary , Ogundiran Opeayo , Pantuvo Jerry Shitta , Oyaole Daniel Rasheed , Tegegne Sisay Gashu , Khalid Abdelrahim , Ilori Elsie , Ojo Olubunmi , Ihekweazu Chikwe , Baraka Fiona , Mulombo Walter Kazadi , Lasuba Clement Lugala Peter , Nsubuga Peter , Alemu Wondimagegnehu 
Published: January 2021

Abstract
Background: Electronic reporting of integrated disease surveillance and response (eIDSR) was implemented in Adamawa and Yobe states, North-East of Nigeria, as an innovative strategy to improve disease reporting. Its objectives were to improve the timeliness and completeness of IDSR reporting by health facilities, prompt identification of public health events, timely information sharing, and public health action. We evaluated the project to determine whether it met its set objectives.Method: We conducted a cross-sectional study to assess and document the lessons learned from the project. We reviewed the performance of the local government areas (LGAs) on timeliness and completeness of reporting, rumors identification, and reporting on the eIDSR and the traditional paper-based system using a checklist. Respondents were interviewed online on the relevance, efficiency, sustainability, project progress and effectiveness, the effectiveness of management, and potential impact and scalability of the strategy using structured questionnaires. Data were cleaned, analyzed, and presented as proportions using an MS Excel spreadsheet. Responses were also presented as direct quotes.Results: The number of health facilities reporting IDSR increased from 103 to 228 (117%) before and after implementation of the eIDSR respectively. The timeliness of reporting was 43% in the LGA compared to 73% in health facilities implementing eIDSR. The completeness of IDSR reports in the last six months before the evaluation was ≥ 85%. Of the 201 rumors identified and verified, 161 (80%) were from the eIDSR pilot sites. The majority of the stakeholders interviewed believed that eIDSR met its predetermined objectives for public health surveillance. The benefits of eIDSR included timely reporting and response to alerts and disease outbreaks, improved timeliness, and completeness of reporting, and supportive supervision to the operational levels. The strategy helped stakeholders to appreciate their roles in public health surveillance.Conclusion: The eIDSR has increased the number of health facilities reporting IDSR, enabled early identification, reporting, and verification of alerts, improved timeliness and completeness of reports, and supportive supervision of staff at the operational levels. It was well accepted by the stakeholder as a system that made reporting easy with the potential to improve the public health surveillance system in Nigeria.
Effects of trees, gardens, and nature trails on heat index and child health: Design and methods of the Green Schoolyards Project
Authors: Lanza Kevin , Alcazar Melody , Hoelscher Deanna M. , Kohl III Harold W. 
Published: January 2021

Abstract
Background: Latinx children in the United States are at high risk for nature-deficit disorder, heat-related illness, and physical inactivity. We developed the Green Schoolyards Project to investigate how green features—trees, gardens, and nature trails—in school parks impact heat index (i.e., air temperature and relative humidity) within parks, and physical activity levels and socioemotional well-being of these children. Herein, we present novel methods for a) observing children’s interaction with green features and b) measuring heat index and children’s behaviors in a natural setting, and a selection of baseline results.Methods: During two September weeks (high temperature) and one November week (moderate temperature) in 2019, we examined three joint-use elementary school parks in Central Texas, United States, serving predominantly low-income Latinx families. To develop thermal profiles for each park, we installed 10 air temperature/relative humidity sensors per park, selecting sites based on land cover, land use, and even spatial coverage. We measured green features within a geographic information system. In a cross-sectional study, we used an adapted version of System for Observing Play and Recreation in Communities (SOPARC) to assess children’s physical activity levels and interactions with green features. In a cohort study, we equipped 30 3rd and 30 4th grade students per school during recess with accelerometers and Global Positioning System devices, and surveyed these students regarding their connection to nature. Baseline analyses included inverse distance weighting for thermal profiles and summing observed counts of children interacting with trees.Results: In September 2019, average daily heat index ranged 2.0°F among park sites, and maximum daily heat index ranged from 103.4°F (air temperature = 33.8°C; relative humidity = 55.2%) under tree canopy to 114.1°F (air temperature = 37.9°C; relative humidity = 45.2%) on an unshaded playground. 10.8% more girls and 25.4% more boys interacted with trees in September than in November.Conclusions: We found extreme heat conditions at select sites within parks, and children positioning themselves under trees during periods of high heat index. These methods can be used by public health researchers and practitioners to inform the redesign of greenspaces in the face of climate change and health inequities.
Changes in Patient Visits and Diagnoses seen in an Academic Ophthalmology Department during the COVID-19 pandemic
Authors: Berkenstock Meghan K , Liberman Paulina , McDonnell Peter J , Chaon Benjamin C 
Published: January 2021

Abstract
BACKGROUND: To minimize the risk of viral transmission, ophthalmology practices limited face to face encounters to only patients with urgent and emergent ophthalmic conditions, in the weeks after the start of the COVID-19 epidemic in the United States. The impact of this is unknown. METHODS: We did a retrospective analysis of the change in the frequency of ICD-10 code use and patient volumes in the six weeks before and after the changes in clinical practice associated with COVID-19.RESULTS: The total number of encounters decreased four-fold after the implementation of clinic changes associated with COVID-19. The low vision, pediatric ophthalmology, general ophthalmology, and cornea divisions had the largest total decrease of in-person visits. Conversely, the number of telemedicine visits increased sixty-fold. The number of diagnostic codes associated with ocular malignancies, most ocular inflammatory disorders, and retinal conditions requiring intravitreal injections increased. ICD-10 codes associated with ocular screening exams for systemic disorders decreased during the weeks post COVID-19. CONCLUSION: Ophthalmology practices need to be prepared to experience changes in practice patterns, implementation of telemedicine, and decreased patient volumes during a pandemic. Knowing the changes specific to each subspecialty clinic is vital to redistribute available resources correctly.
A potential suite of climate markers of long-chain n-alkanes and alkenones preserved in the top sediments from the Pacific sector of the Southern Ocean
Authors: Chen Xin , Liu Xiaodong , Lin Da-Cheng , Wang Jianjun , Chen Liqi , Yu Pai-Sen , Wang Linmiao , Xiong Zhifang , Chen Min-Te 
Published: January 2021

Abstract
Investigating organic compounds in marine sediments can potentially unlock a wealth of new information in these climate archives. Here we present pilot study results of organic geochemical features of long-chain n-alkanes and alkenones and individual carbon isotope ratios of long-chain n-alkanes from a newly collected, approximately 8-meter long, located in the far reaches of the Pacific sector of the Southern Ocean. We analyzed a suite of organic compounds in the core. The results show abundant long-chain n-alkanes (C29-C35) with predominant odd-over-even carbon preference, suggesting an origin of terrestrial higher plant waxes via long-range transport of dust, possibly from Australia and New Zealand. The δ13C values of the C31 n-alkane range from -29.4 to -24.8‰, in which the higher δ13C values suggest more contributions from C4 plant waxes. In the analysis, we found that the mid-chain n-alkanes (C23-C25) have a small odd-over-even carbon preference, indicating that they were derived from marine non-diatom pelagic phytoplankton and microalgae and terrestrial sources. Furthermore, the C26 and C28 with lower δ13C values (~ -34‰) indicate an origin from marine chemoautotrophic bacteria. We found that the abundances of tetra-unsaturated alkenones (C37:4) in this Southern Ocean sediment core ranges from 11-37%, perhaps a marker of low sea surface temperature (SST). The results of this study strongly indicate that the δ13C values of long-chain n-alkanes and index are potentially useful to reconstruct the detailed history of C3/C4 plants and SST change in the higher latitudes of the Southern Ocean.