bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A Rare Case of Silent Sinus Syndrome and Vertical Diplopia
Authors: Le Joan K. 
Published: July 2020

SIGNIFICANCE
Silent sinus syndrome is classically a maxillary sinus disease characterized by transient and variable vertical diplopia, hypoglobus, and enophthalmos. Uncommon presentations may exist, and although rare, it should be considered when diagnostic testing is inconsistent with more common etiologies of diplopia.

PURPOSE
This study aimed to report an unusual presentation of silent sinus syndrome and review the thought process in diagnosing and managing this condition.

CASE REPORT
A 65-year-old white man presented to the eye clinic with left upper eyelid ptosis and intermittent vertical diplopia of 2-month onset. Clinical testing was variable, and initial differential diagnoses included a partial left pupil–sparing third nerve palsy involving the superior division, myasthenia gravis, and orbital disease. After extensive workup and review of his computed tomography images, the patient was diagnosed with severe chronic pansinusitis with an underlying condition known as silent sinus syndrome. He was referred to otorhinolaryngology for sinus decompression and oculoplastics for orbital reconstruction. While awaiting orbital reconstruction after decompression of multiple sinuses, he returned reporting a significant reduction in his diplopia.

CONCLUSIONS
Vertical diplopia is a common complaint in primary care optometry. It is important to delve into more rare etiologies when clinical, laboratory, and radiological studies do not support the more common diagnoses.
Intra–Right Ventricle Course of the Coronary Arteries on Computed Tomography Angiography
Authors: Tyczyński Paweł , Skowroński Jarosław , Opolski Maksymilian P. , Pręgowski Jerzy , Kępka Cezary , Kruk Mariusz , Orczykowski Michał , Łazarczyk Hubert , Witkowski Adam , Michałowska Ilona 
Published: July 2020

BackgroundThe clinical relevance and anatomic characteristics of intracavitary coronary arteries coursing within the right ventricle (RV) are largely unknown.ObjectivesThe aim of our study was to assess the clinical and computed tomographic characteristics of patients diagnosed with intracavitary coronary arteries coursing within RV (intra-RV coronaries).MethodsElectronic records from a single high-volume cardiac center were retrospectively screened for the presence of intra-RV coronaries among consecutive patients who underwent coronary computed tomography angiography (coronary CTA) from 2008 to 2019.ResultsOverall, 31,748 coronary CTA reports were evaluated, and 17 subjects with intra-RV coronaries were identified. None of these patients was referred for subsequent invasive coronary angiography. One patient underwent coronary artery bypass grafting, 1 patient had a history of percutaneous coronary intervention, and 1 patient had a concomitant coronary anomaly: left circumflex coronary artery originating from the right coronary artery. All of the involved coronaries (n = 17) were the left anterior descending coronary arteries (LADs). Typical segmental coronary course within RV was along the border between free RV wall and interventricular septum (beneath interventricular groove), often within trabeculae carneae of the RV. Only the midsegment and distal segment of the LAD traversed within the RV. The mean ± SD distance from the aorta to the coronary entrance into the RV was 74.5 ± 17.1 mm, whereas the mean ± SD intra-RV coronary length was 25.1 ± 14.0 mm.ConclusionsIntra-RV course of the coronaries in an adult CTA population is an infrequent anatomical variant involving LAD. It may require additional attention during interventional and surgical interventions.
Patterns of Gray Matter Volume Alterations in Hemodialysis Patients With and Without Restless Legs Syndrome: Evidence From a Voxel-Based Morphometry Study
Authors: Wang Hao , Han Xue , Jin Mei , Zhang Peng , Wang Zheng , Lv Han , Ding He-yu , Zhang Zheng-yu , Zhao Peng-fei , Li Jing , Yang Zheng-han , Liu Wen-hu , Wang Zhen-chang 
Published: July 2020

PurposeThe purpose of this study was to investigate the differences of gray matter volume (GMV) alteration patterns between hemodialysis with restless legs syndrome (HD-RLS) and hemodialysis without restless legs syndrome (HD-nRLS) patients using voxel-based morphometry.MethodsTwenty-three HD-RLS patients, 27 HD-nRLS patients, and 27 age-, sex-, and education-matched healthy controls were included in this study. One-way analysis of covariance and post hoc analyses were used to assess differences in GMV, demographics, and clinical data among the 3 groups. Pearson correlation analysis was conducted between altered GMV in the HD-RLS group and clinical data.ResultsCompared with HD-nRLS patients, HD-RLS patients showed decreased GMV in the left primary motor cortex (false discovery rate corrected,P< 0.05). Compared with the healthy controls, both HD subgroups (ie, those with and without RLS) exhibited consistent GMV changes, including decreased GMV in the bilateral anterior cingulate and paracingulate gyrus and left middle temporal gyrus (false discovery rate corrected,P< 0.05). The GMV values in the left precentral gyrus were negatively correlated with the RLS rating scores (r= 0.2138,P= 0.0263).ConclusionsThis abnormal decreased GMV in the sensorimotor cortex provides evidence for a sensory processing disorder in RLS that may be involved in the pathogenesis of RLS in HD patients.
Coronary Sinus Diameter to Inferior Vena Cava Diameter Ratio in the Diagnosis of Cardiac Tamponade: A Novel Approach
Authors: Ozcan Cetin Elif Hande , Cetin Mehmet Serkan , Könte Hasan Can , Tak Bahar Tekin , Ekizler Firdevs Aysenur , Ozcan Fırat , Cay Serkan , Ozeke Ozcan , Akcay Burak , Topaloglu Serkan , Aras Dursun 
Published: July 2020

Background
In cardiac tamponade, coronary sinus (CS) as an intrapericardial structure can be easily compressed, whereas inferior vena cava (IVC) dilates. This inverse relationship may augment their roles in the evaluation of tamponade imaging.

Aim
We assessed the usefulness of computerized tomographic measures of CS diameter and also CS/IVC ratio to predict tamponade in clinically stable patients with large pericardial effusion.

Methods
Sixty-six clinically stable patients who had large pericardial effusions were included. Coronary sinus diameter was measured from the point at 1 cm proximal to the CS ostium. Inferior vena cava diameter was measured from the segment between its right atrial orifice and hepatic vein.

Results
Patients with tamponade had smaller CS diameter and CS/IVC ratio. After adjusting with other parameters, only either CS diameter or CS/IVC ratio predicted tamponade, respectively. (Nagelkerke r
2 value for CS was 53.7% and 72.1% for CS/IVC ratio). In Receiver Operating Characteristic Curve analysis, a cutoff value of 6.85 mm for CS diameter had 82.6% sensitivity and 83.7% specificity and a cutoff value of 27% for CS/IVC ratio had 87.0% sensitivity and 86.0% specificity for predicting cardiac tamponade.

Conclusions
The tomographic measures of both the CS diameter and the CS/IVC ratio predicted tamponade in clinically stable patients with large pericardial effusion. Compared with CS diameter, CS/IVC ratio seemed to be a more powerful predictor of tamponade.
Increased serum levels of soluble TNF-α receptor is associated with mortality of ICU COVID-19 patients
Authors: Mortaz Esmaeil , Tabarsi Payam , Jamaati Hamidreza , Roofchayee Neda Dalil , K.Dezfuli Neda , Hashemian Seyed Mohamadreza , Moniri Afshin , Marjani Majid , Malkmohammad Majid , Mansouri Davood , Varahram Mohammad , Folkerts Gert , Adcock Ian M 
Published: July 2020

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has spread to almost 100 countries, infected over 10M patients and resulted in 505K deaths worldwide as of 30thJune 2020. The major clinical feature of severe COVID-19 requiring ventilation is acute Respiratory Distress Syndrome (ARDS) with multi-functional failure as a result of a cytokine storm with increased serum levels of cytokines such as TNF-α and IL-6 being reported. TNF-α levels are increased during the cytokine storm in very ill patients and soluble receptors for IL-6 and IL-2 are present in the blood of COVID-19 patients,ObjectivesTo elucidate the involvement of serum levels of soluble TNF-Receptor of severe and mild COVID-19 patients to determine for severity of disease.MethodWe recruited16 severe COVID-19 patients in the ICU on ventilator support and 26 milder COVID-19 patients who were hospitalised but not within the intensive care unit (ICU) between March-May 2020 at the Masih Daneshvari Hospital Tehran, Iran. After harvesting of whole blood the serum was isolated and soluble TNF-Receptor levels measured by ELISA.ResultsSerum levels of the usually inhibitory soluble TNF-α receptor 1 (sTNFαR1) were significantly elevated in severe COVID-19 patients at admission to ICU. High serum levels of sTNFαR1 were associated with mortality of severe COVID-19 patients treated within ICU.ConclusionsThis pilot study demonstrates for role of STNF-αR1 receptor in severity of disease. Future studies should examine whether lower levels of systemic sTNFαR1 at admission may indicate a better disease outcome.
Association between epidemic dynamics of Covid-19 infection and ABO blood group types
Authors: Liu Yuefei , Häussinger Lisa , Steinacker Jürgen M. , Dinse-Lambracht Alexander 
Published: July 2020

AbstractBackgroundCovid-19 pandemic is the most critical challenge nowadays for the manhood, and the infection and death cases are still speedily increasing. Since there are no available vaccine and specifically effective treatment, to break the infectious way of the pandemic remains the unique measure to efficiently combat Covid-19 infection. Understanding factors that affect the Covid-19 infection can help make better balance between activity restriction and infection dynamics. This study sought to investigate association between Covid-19 infection and blood type distribution.MethodsThe big data provided by World Health Organization and Johns Hopkins University were taken to assess epidemic dynamics of Covid-19 infection. Growth rate and doubling time of infection and death cases, reproductive number, infection and death cases in the mid-exponential phase were analyzed in relation to blood type distribution.ResultsGrowth rate of infection and death cases correlated significantly to blood type A proportion of the population positively while to blood type B proportion negatively. In comparison with lower blood type A population (< 30%) people with higher blood type A (≥ 30%) had more infection and death cases in the early exponential phase, higher growth rates, and shorter case doubling time for infection and death.DiscussionCovid-19 infection is significantly associated with blood type distribution and people with blood type A are more susceptible to Covid-19 infection and have higher epidemic dynamics and higher case fatality rate. The results of this study provide important and useful information for fighting Covid-19 pandemic.
Association between health-related hope and adherence to prescribed treatment in CKD patients: multicenter cross-sectional study
Authors: Kurita Noriaki , Wakita Takafumi , Ishibashi Yoshitaka , Fujimoto Shino , Yazawa Masahiko , Suzuki Tomo , Koitabashi Kenichiro , Yanagi Mai , Kawarazaki Hiroo , Green Joseph , Fukuhara Shunichi , Shibagaki Yugo 
Published: July 2020

AbstractBackgroundIn chronic kidney disease (CKD), patients’ adherence to prescriptions for diet and for medications might depend on the degree to which they have hope that they will enjoy life, and that hope could vary with the stage of CKD. The aims of this study were to quantify both the association of CKD stage with health-related hope (HR-Hope), and the association of that hope with psychological and physiological manifestations of adherence.MethodsThis was a cross-sectional study involving 461 adult CKD patients, some of whom were receiving dialysis. The main exposure was HR-Hope, measured using a recently-developed 18-item scale. The outcomes were perceived burden of fluid restriction and of diet restriction, measured using the KDQOL, and physiological manifestations of adherence (systolic and diastolic blood pressure [BP], and serum phosphorus and potassium levels).General linear models and generalized ordered logit models were fit.ResultsParticipants at non-dialysis stage 4 and those at stage 5 had lower HR-Hope scores than did those at stage 2 or 3 (combined). Those at non-dialysis stage 5 had the lowest scores. HR-Hope scores of participants at stage 5D were similar to those of participants at stage 4, but they were lower than the scores of participants at stage 2 or 3 (combined). Higher HR-Hope scores were associated with lower perceived burdens of fluid restriction and of diet restriction (adjusted ORs per ten-point difference were 0.82 and 0.84, respectively). Higher HR-Hope scores were associated with lower systolic BP (adjusted mean difference in systolic BP per ten-point difference in HR-Hope scores was -1.87 mmHg). In contrast, HR-Hope scores were not associated with diastolic BP, serum phosphorus levels, or serum potassium levels.ConclusionsAmong CKD patients, HR-Hope is associated with disease stage, with psychological burden, and with some physiological manifestations of adherence.
Work-related and Personal Predictors of COVID-19 Transmission
Authors: Anand Paul , Allen Heidi , Ferrer Robert , Gold Natalie , Gonzales Martinez Rolando Manuel , Kontopantelis Evan , Krause Melanie , Vergunst Francis 
Published: July 2020

AbstractThe paper provides new evidence from a survey of 2000 individuals in the US and UK related to predictors of Covid-19 transmission. Specifically, it investigates work and personal predictors of transmission experience reported by respondents using regression models to better understand possible transmission pathways and mechanisms in the community. Three themes emerge from the analysis. Firstly, transport roles and travelling practices are significant predictors of infection. Secondly, evidence from the US especially shows union membership, consultation over safety measures and the need to use public transport to get to work are also significant predictors. This is interpreted as evidence of the role of deprivation and of reactive workplace consultations. Thirdly and finally, there is some, often weaker, evidence that income, car-owership, use of a shared kitchen, university degree type, risk-aversion, extraversion and height are predictors of transmission. The comparative nature of the evidence indicates that the less uniformly stringent nature of the US lockdown provides more information about both structural and individual factors that predict transmission. The evidence about height is discussed in the context of the aerosol transmission debate. The paper concludes that both structural and individual factors must be taken into account when predicting transmission or designing effective public health measures and messages to prevent or contain transmission.JEL CodesI1 I12 I14 I18
Analysis of COVID-19 cases and associated ventilator requirement in Indian States
Authors: Dhanya V , Anitha R , Kishan Ashwini Kumar , Sumathi S R , Roy Amrit 
Published: July 2020

AbstractAnalysis of COVID-19 cases and prediction of quantity of associated ventilator requirement is very relevant during this pandemic. This paper presents a method for predictive estimation of ventilator requirement for COVID-19 patients in Indian states. It uses ARIMA (Autoregressive Integrated Moving Average) model for predicting the future cumulative cases and daily fatality. Taking cue from this, ventilator requirement is estimated for each state. State wise estimation of ventilator is important because public healthcare system in India is managed at state level. Dataset on Novel Corona Disease 2019 in India from Kaggle website is used in this work.
Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity
Authors: Montague Zachary , Lv Huibin , Otwinowski Jakub , DeWitt William S. , Isacchini Giulio , Yip Garrick K. , Ng Wilson W. , Tsang Owen Tak-Yin , Yuan Meng , Liu Hejun , Wilson Ian A. , Peiris J. S. Malik , Wu Nicholas C. , Nourmohammad Armita , Mok Chris Ka Pun 
Published: July 2020

AbstractCOVID-19 patients show varying severity of the disease ranging from asymptomatic to requiring intensive care. Although a number of SARS-CoV-2 specific monoclonal antibodies have been identified, we still lack an understanding of the overall landscape of B-cell receptor (BCR) repertoires in COVID-19 patients. Here, we used high-throughput sequencing of bulk and plasma B-cells collected over multiple time points during infection to characterize signatures of B-cell response to SARS-CoV-2 in 19 patients. Using principled statistical approaches, we determined differential features of BCRs associated with different disease severity. We identified 38 significantly expanded clonal lineages shared among patients as candidates for specific responses to SARS-CoV-2. Using single-cell sequencing, we verified reactivity of BCRs shared among individuals to SARS-CoV-2 epitopes. Moreover, we identified natural emergence of a BCR with cross-reactivity to SARS-CoV-1 and SARS-CoV-2 in a number of patients. Our results provide important insights for development of rational therapies and vaccines against COVID-19.
Asthma in COVID-19: An extra chain fitting around the neck?
Authors: Hussein Mohammad Hosny , Toraih Eman Ali , Attia Abdallah S , Youssef Mohanad , Omar Mahmoud , Burley Nicholas , Zhang Allen D. , Roos Jackson , Houghton August , Aniemeka Nedum , Shama Mohamed Ahmed , Duchesne Juan , Kandil Emad 
Published: July 2020

AbstractIntroductionThe novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe, overwhelming healthcare systems and depleting resources. The infection has a wide spectrum of presentations, and pre-existing comorbidities have been found to have a dramatic effect on the disease course and prognosis. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients.MethodsWe conducted a multi-center retrospective study of positively confirmed COVID-19 patients from multiple hospitals in Louisiana. Demographics, medical history, comorbidities, clinical presentation, daily laboratory values, complications, and outcomes data were collected and analyzed. The primary outcome of interest was in-hospital mortality. Secondary outcomes were Intensive Care Unit (ICU) admission, risk of intubation, duration of mechanical ventilation, and length of hospital stay.ResultsA total of 502 COVID-19 patients (72 asthma and 430 non-asthma cohorts) were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%, higher than the national prevalence of asthma (7.7%). Univariate analysis revealed that asthma patients were more likely to be obese (75% vs 54.2%,p=0.001), with higher frequency of intubation (40.3% vs 27.8%,p= 0.036), and required longer duration of hospitalization (15.1±12.5 vs 11.5±10.6,p=0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR=1.81, 95%CI=0.98-3.09,p=0.06), endotracheal intubation (OR=1.77, 95%CI=0.99-3.04,p=0.06) or complications (OR=1.37, 95%CI=0.82-2.31,p=0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR=1.48, 95%CI=0.82-2.66, p=0.20) or with the duration of ICU stay (OR=0.76, 95%CI=0.28-2.02,p=0.58). Kaplan-Meier curve showed no significant difference in overall survival of the two groups (p=0.65).ConclusionDespite the increased prevalence of hospitalization in asthmatic COVID-19 patients compared to the general population, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes.
Consistent Consideration of RNA Structural Alignments Improves Prediction Accuracy of RNA Secondary Structures
Authors: Tagashira Masaki 
Published: July 2020

ABSTRACTThe probabilistic consideration of the global pairwise sequence alignment of two RNAs tied with their global single secondary structures, or global pairwise structural alignment, is known to predict more accurately global single secondary structures of unaligned homologs by discriminating between conserved local single secondary structures and those not conserved. However, conducting rigorously this consideration is computationally impractical and thus has been done to decompose global pairwise structural alignments into their independent components, i.e. global pairwise sequence alignments and single secondary structures, by conventional methods. ConsHomfold and ConsAlifold, which predict the global single and consensus secondary structures of unaligned and aligned homologs considering consistently preferable (or sparse) global pairwise structural alignments on probability respectively, were developed and implemented in this study. These methods demonstrate the best trade-off of prediction accuracy while exhibiting comparable running time compared to conventional methods. ConsHomfold and ConsAlifold optionally report novel types of loop accessibility, which are useful for the analysis of sequences and secondary structures. These accessibilities are average on sparse global pairwise structural alignment and can be computed to extend the novel inside-outside algorithm proposed in this study that computes pair alignment probabilities on this alignment.
SmartPeak automates targeted and quantitative metabolomics data processing
Authors: Kutuzova Svetlana , Colaianni Pasquale , Röst Hannes , Sachsenberg Timo , Alka Oliver , Kohlbacher Oliver , Burla Bo , Torta Federico , Schrübbers Lars , Kristensen Mette , Nielsen Lars , Herrgård Markus J. , McCloskey Douglas 
Published: July 2020

AbstractSmartPeak is an application that encapsulates advanced algorithms to enable fast, accurate, and automated processing of CE-, GC- and LC-MS(/MS) data, and HPLC data for targeted and semi-targeted metabolomics, lipidomics, and fluxomics experiments.HighlightsNovel algorithms for retention time alignment, calibration curve fitting, and peak integrationEnables reproducibility by reducing operator bias and ensuring high QC/QAAutomated pipeline for high throughput targeted and/or quantitative metabolomics, lipidomics, and fluxomics data processing from multiple analytical instrumentsManually curated data set of LC-MS/MS, GC-MS, and HPLC integrated peaks for further algorithm development and benchmarking