bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of exacerbation and risk factors for postoperative adjuvant endocrine therapy- related arthralgia in patients with breast cancer: a prospective cohort study
Authors: Uno Maya , Takahashi Yuko , Hatono Minami , Kawada Kengo , Tsukioki Takahiro , Kochi Mariko , Ikeda Hirokuni , Iwatani Tsuguo , Iwamoto Takayuki , Hara Kyoko , Ogasawara Yutaka , Yoshitomi Seiji , Doihara Hiroyoshi , Shien Tadahiko , Taira Naruto , Toyooka Shinichi 
Published: December 2024

Abstract

Background: Postoperative endocrine therapy is crucial in reducing breast cancer recurrence; however, low completion rates attributable to arthralgia pose challenges. Furthermore, the specific risk factors for endocrine therapy-related arthralgia and the impact of lifestyle factors, such as soy isoflavone intake, as well as equol production capacity, on arthralgia remain elusive. Therefore, this study was undertaken to determine the frequency and risk factors for adjuvant endocrine therapy-related arthralgia in Japan, with a specific focus on the influence of soy isoflavone on this condition.
Methods: A prospective cohort of patients commencing adjuvant endocrine therapy post-breast cancer surgery at three centers in Japan was followed up for one year after treatment initiation. Data on clinicopathological background, social background, and lifestyle status, such as soy isoflavone intake,were collected from electronic medical records and self-administered questionnaires. The presence or absence of equol production capacity was assessed via urinalysis without soy food loading. The incidence of arthralgia was investigated using the Patient-Reported Outcome-Common Terminology Criteria for Adverse Events. Cox proportional hazard tests were used to examine risk factors for endocrine therapy-related arthralgia.
Results: Among the 297 patients included in this study, 138 were started on tamoxifen (TAM) and 159 on aromatase inhibitors (AIs). During the observation period, 64.6% of patients experienced exacerbation or onset of arthralgia, and 14.0% reported interference with daily activities owing to arthralgia. The risk factor for arthralgia was AI use (vs. TAM), and those for arthralgia-related interference encompassed smoking (vs. no smoking history) and major depressive disorder (vs. normal). Moreover, being more than 20 years postmenopausal (vs. premenopausal) was an independent risk-reducing factor.
Conclusions: The risk factors for endocrine therapy-related arthralgia in Japan included AI use, smoking, and depression. However, no significant association was observed between endocrine therapy-related arthralgia and high or low soy isoflavone intake, as well as the presence or absence of equol-producing capacity.
Trial Registration: This study has been registered and published in the University Hospital Medical Information Network-Clinical Trials Registry (Study ID: UMIN000030099) on January 25, 2018.
B lymphocyte subset-based stratification in primary Sjögren's syndrome: implications for lymphoma risk and personalized treatment
Authors: Qi Xuan , Zhao Doudou , Wang Naidi , Han Yipeng , Huang Bo , Feng Ruiling , Jin Yuebo , Wang Ruoyi , He Jing 
Published: December 2024

Abstract

Objective
This study aimed to perform a detailed stratification analysis of B lymphocyte subsets in patients with primary Sjögren's syndrome (pSS) and to investigate their associations with lymphoma risk, clinical phenotypes, and disease activity.
Methods
In this retrospective study, we analyzed data from 137 patients with pSS. We employed machine learning approaches, specifically principal component analysis (PCA) and k-means clustering, to examine B lymphocyte subset distributions from flow cytometry data and immunoglobulin IgG and complement (C3, C4) levels. The optimal cluster number was determined using the Elbow Method in R software. Based on these 10 variables, patients were categorized into distinct subgroups. We then comprehensively compared clinical characteristics, laboratory parameters, and disease activity indices among these identified subgroups.
Results
Four distinct subgroups were identified. Cluster A exhibited a significantly higher lymphoma incidence rate of 20%, compared to 3.39% in Cluster B and 0% in Clusters C and D (p = 0.007). Cluster A also had the highest percentage of double-negative B cells (32.26 ± 17.96%) and plasma cells (2.02 ± 1.92%). ESSDAI scores indicated that disease activity was highest in Cluster A (9.00, 6.00–20.00), followed by Clusters B (7.00, 3.50–14.00), C (6.00, 1.25–17.50), and D (5.00, 1.50–9.00), respectively.
Conclusion
This innovative stratification method revealed the critical role of B cell subset imbalance in the pathogenesis of pSS and provided new evidence for predicting lymphoma risk and guiding personalized treatment.
The impact of sagittal cortical support on stability after internal fixation of intertrochanteric femoral fractures: a finite element analysis
Authors: Miao Jinhu , Dai Jin , Chen Zhihao , Liu Yadong , Shao Guoxi 
Published: December 2024

Abstract

Objective: To explore the optimal sagittal cortical support reduction mode with proximal femoral bionic nails (PFBN) for treating intertrochanteric femoral fractures (ITFFs) with medial wall defects to prevent internal fixation failure.
Methods: A 64-year-old healthy male volunteer with no history of hip or systemic disease was recruited. High-resolution computed tomography images with a slice thickness of 0.602 mm of his right femur were obtained. These images were used to establish three-dimensional (3D) models. The lesser trochanter and medial wall were cut off to create an AO Foundation/Orthopaedic Trauma Association (AO/OTA) type 31-A1.3 pertrochanteric fracture model. PFBN was used to simulate fixation. Under the conditions of coronal anatomical reduction, eighteen different fracture sagittal reduction modes were examined, which included intact or defective medial walls, as well as neutral, negative 5%,10%,15%,20%, and positive 5%,10%,15%,20%, were simulated. A load of 600 N was applied to simulate a 60 kg elderly patient standing on one leg. The models were subjected to finite element analysis (FEA). The displacement and von Mises stress distributions were analyzed.
Results: Under the conditions of an intact or defective medial wall, the 10% positive sagittal cortical support reduction pattern showed minimal stress and displacement. In the case of medial wall defects, with 20% loss of reduction in both negative and positive sagittal mal reduction, the maximum equivalent stresses were 188.52 MPa and 211.21 MPa, respectively, which are 2.66 and 2.98 times greater than the maximum equivalent stress of 70.761 MPa observed when the medial wall was intact. Meanwhile, the 20% negative reduction pattern seemed to have the largest displacement.
Conclusion: Under the conditions of an intact or defective medial wall, the 10% positive sagittal support reduction pattern showed the best mechanical stability for ITFF. The negative support reduction pattern was prone to fixation failure and should be avoided during an operation.
Assessing the acute effects of diagonal mobilization on static and dynamic balance in young football players: A randomized double-blind study
Authors: Studnicki Rafał , Taraszkiewicz Marcin , Hansdorfer-Korzon Rita , Kawczyński Adam 
Published: December 2024

Abstract

This randomized double-blind study aimed to assess the acute effects of manual therapy focusing on diagonal sliding (DM) on the static and dynamic balance of young male and female soccer players. Thirty-two regional-level footballers aged between 14 and 16 were randomly assigned to either receive DM or to a control group exposed to a placebo condition. Participants underwent assessment twice: once before the intervention and again afterward. Tests included the single leg lend and hold test and the single leg standing test, measured using force plates. The following variables were recorded: time to stabilization, peak drop landing force, as well as center of pressure (CP) range in the anterior-posterior and medial-lateral directions, and mean velocity while standing on one leg. Significant interactions time × group were found in CP media-lateral (p = 0.003), CP anterior-posterior (p = 0.006), CP mean velocity (p = 0.044), time to stabilization (p < 0.001), and peak drop landing force (p = 0.347;). Within-experimental group analysis (post-pre) revealed significant differences in CP media-lateral (p = 0.001), CP anterior-posterior (p = 0.012), CP mean velocity (p < 0.001), time to stabilization (p < 0.001) and peak drop landing force (p = 0.425). The time to stabilization and the center of pressure range in the anterior-posterior and medial-lateral directions were significantly influenced by the DM intervention. Therefore, it is recommended that individuals involved in clinical or sports settings consider this approach in future analyses.
Sepsis secondary to co-infection with malaria, dengue and COVID 19 : a case report
Authors: Guibla Ismael , Zabramba Augustin , Traore Salah Idriss Seif , Tankoano Aida Ida , Ilboudo Charles Sombewindé , Ouédraogo R Franks Aymar , Ouédraogo Matharie Donalde , Poda Armel , Traoré Ibrahim Alain 
Published: December 2024

Abstract

The co-infection of malaria, dengue fever and COVID-19 is rarely described in sub-Saharan Africa. We report a case of co-infection of malaria, dengue fever and COVID-19 complicated by sepsis requiring an admission in intensive care unit. The diagnosis of COVID-19 was delayed due to the classical signs of malaria and dengue fever. This trio should be systematically considered in the context of any infectious presentation in sub-Saharan Africa, especially during the winter season, as symptoms and biological parameters are not discriminative.
Cybersecurity Culture Among Healthcare Workers in Indonesia: Knowledge Gaps, Demographic Influences, and Strategic Policy Solutions
Authors: Irwandy Irwandy , Mangilep Adelia U. Ady , Anggraeni Rini , Noor Noer Bahry , Niartiningsih Andi , Latifah Nur 
Published: December 2024

Abstract

Introduction: Digitalization in healthcare has increased cybersecurity risks, especially in regions with limited protective measures. In Indonesia, the cybersecurity culture among healthcare professionals remains underdeveloped, posing potential threats to patient data security.
Objectives: This study assessed cybersecurity culture among healthcare workers in Makassar, Indonesia, focusing on their knowledge, attitudes, and practices, and examined the influence of demographics on these factors.
Methods: A cross-sectional survey was conducted with 574 healthcare workers from three hospitals in Makassar. The survey measured cybersecurity knowledge, attitudes, and practices, and analyzed demographic influences such as age, gender, and profession.
Results: Findings revealed substantial knowledge gaps, with 61.7% of respondents unaware of cybersecurity policies, and 65.5% unable to recognize email fraud. Although attitudes toward security were generally positive, risky behaviors—such as using personal devices for sensitive data (72.1%) and installing unauthorized software (70.2%)—persisted. Younger healthcare workers and nurses exhibited stronger cybersecurity practices, while older staff and physicians had lower compliance.
Conclusion: This study underscores an urgent need for comprehensive cybersecurity training, policy clarity, and leadership support in Indonesian healthcare. Targeted interventions based on demographic factors could enhance adherence to cybersecurity practices, bolstering patient data protection and healthcare system resilience.
Prospective Study of Safety and Biomarkers Using Multimodal Analysis with Swept-Source Oct and Oct-Angiography in Patients with Dry Age Related Macular Degeneration Treated with Photobiomodulation.
Authors: Rezende Marcussi Palata , Faria Fernanda Atoui , Polido Julia , Belfort Rubens , Cabral Thiago 
Published: December 2024

Abstract

Background:
The Photobiomodulation-Valeda device is an innovative approach for treating dry age-related macular degeneration (AMD). The main objective of this study was to conduct a multimodal imaging analysis using swept-source technology in OCT (SS-OCT) and OCT-Angiography (SS-OCTA) in patients with dry AMD treated with Photobiomodulation (PBM), focusing primarily on safety and biomarkers.
Materials and Methods:
A prospective interventional study was conducted involving 19 patients (25 eyes) diagnosed with dry AMD. The treatment consisted of nine sessions of PBM using the Valeda Light Delivery System. Various biomarkers were assessed before and one week after the treatment, including Best Corrected Visual Acuity (BCVA) for logMAR, central macular thickness (CMT), subfoveal choroidal thickness (SCT), capillary density (CD), and avascular areas of the superficial (AASP) and deep plexus (AADP).
Results:
The study included 25 eyes, predominantly in AREDS category II. Significant improvements were observed in BCVA (p = 0.001). No significant changes were observed in CMT, SCT, CD, AASP, and AADP (p > 0,05). The treatment was well tolerated, with few mild side effects, and no patient developed wet AMD.
Conclusion:
PBM-Valeda therapy shows promise as a treatment strategy for dry AMD, resulting in improved visual acuity (as previously demonstrated in Lightsite I, II, and III). It is important to emphasize the safety of the treatment, as none of the biomarkers (CMT, SCT, CD, AASP, and AADP) exhibited harmful changes. Side effects were minimal, there were no signs of retinotoxicity, and no patient developed exudative AMD, after 1 cycle: 9 sessions of PBM treatment.
Contraceptive use after bariatric surgery
Authors: Tanjaturon Kasidech , Uaamnuichai Sutira , Suphapimol Suphachai , Porntawansak Gade , Kachornvitaya Pattharasai , Udomsawaengsup Suthep , Jaisamrarn Unnop , Santibenchakul Somsook 
Published: December 2024

Abstract

Background
Bariatric surgery is an effective intervention for morbid obesity with established short-term efficacy for weight reduction and long-term efficacy in improving health outcomes. Pregnancy is contraindicated in the first year after bariatric surgery and therefore necessitates careful contraceptive planning to reduce pregnancy complications. This study aimed to assess contraceptive use and counseling among women with obesity before and after bariatric surgery at King Chulalongkorn Memorial Hospital.
Methods
This descriptive study, including a retrospective group with data from records and a prospective group followed over time, was conducted from July 31, 2023, to May 26, 2024.The study included 90 reproductive-aged women who underwent bariatric surgery between January 1, 2018, and October 31, 2023. Participants were surveyed on contraceptive use, counseling, and related factors. Data were collected from medical records and through questionnaires.
Results
In this study, 85.7% of sexually active participants used contraception 6–12 months after surgery, with male condoms being the most common method. Only 31.4% of the participants used effective contraception (including male and female sterilization, contraceptive implants, intrauterine devices, and depot medroxyprogesterone acetate). Contraceptive counseling was most frequent before surgery and 3 months after surgery; however, seven participants did not receive adequate information about the appropriate contraception for their condition.
Conclusion
Although the contraceptive prevalence among participants was relatively high, the use of effective contraception was low. The study highlights the need for improved contraceptive counseling and education in patients who have undergone bariatric surgery. Enhanced counseling can help in selecting safe and effective contraceptive methods and reducing the risk of unintended pregnancies during the first year after surgery, a period considered unsafe for pregnancy.
Significance of mineral elements characterization for anaerobic digestion substrates: The case of avocado oil processing by-products
Authors: Rashama Charles , Ijoma Grace N , Matambo Tonderayi S. , Riann Christian 
Published: December 2024

Abstract

Mineral elements effects on anaerobic biogas production (AD) were reviewed and inferences made for avocado oil processing by-products. Mineral elements in these by-products were measured using ICP-OES methods. It was noted that there is no consensus among researchers on absolute mineral requirements for optimal digester performance and only ranges stating lowest and highest mineral requirements could be found from different studies. These ranges vary for each element depending on analytical methods used, substrate type and digester operating conditions. Mineral elements exceeding certain limits in digesters can be toxic to the AD microorganisms, a situation which negatively affect the efficiency and stability of substrate biodegradation to biogas. Other mineral elements, such as arsenic, despite their concentration in the digester, are naturally toxic to microorganisms. These toxic minerals must therefore be removed or detoxified if detected in substrates. Researchers choose to perform substrate mineral elemental analysis depending on their pre-existing knowledge of the substrate, recommendations from standards adopted in the research and objective of their studies. The bioavailability of minerals in substrates require further investigation to accurately correlate mineral elements concentration in avocado oil processing by-products by ICP-EOS methods to the expected AD performance when using these substrates. The current study revealed mineral elements related to avocado oil processing by-products that may need possible attention for optimal biodegradation of these substrates to biogas.
Validation and in-silico function prediction of circTIAL1 as a novel marker of abnormal lung development in nitrofen-induced Congenital Diaphragmatic Hernia (CDH)
Authors: Jank M. , Kraljevic M. , Aptekmann A. O. , Patel D. , Boettcher M. , LeDuc R. , Keijzer Richard 
Published: December 2024

Abstract

PURPOSE
Circular RNAs (circRNAs) are stable, non-coding RNAs with tissue- and developmental-specific expression making them suitable biomarkers for congenital anomalies. Current circRNA discovery pipelines have focused on human and mouse. We aim to bridge this gap by combining bioinformatics resources and used circTIAL1 as a model candidate in the nitrofen rat model of congenital diaphragmatic hernia (CDH).
METHODS
CircTIAL1 backsplice junction sequences from a microarray were used to predict mature circRNA sequences and downstream pathways by miRNA interactions using CRAFT and circAtlas. We validated circTIAL1 expression using conventional PCR, amplicon sequencing, RT-qPCR and Basescope™ in situ hybridization.
RESULTS
Expression of parental gene Tial1 was decreased in nitrofen-induced lungs at embryonic day (E)15 (p = 0.004) and E21 (p = 0.008); while at E18 there was no significant difference (p = 0.65). At E21, circTIAL1 expression did not differ between CDH and control lungs (p = 0.07); however, there was a decreased expression in male pups (p = 0.0167). In situ hybridization confirmed low circTIAL1 expression. CircRNA::miRNA::mRNA interactions revealed pathway enrichment for inflammation/infection and neuron function/development.
CONCLUSION
For the first time, we report circRNA profiling in nitrofen-induced CDH with a sex-specific expression of circTIAL1. Current bioinformatics tools have significant challenges, but can guide hypothesis formation on their biological role.
Machine Learning-Based Prediction of Depression Risk in Patients with Multimorbidity: A Study Using NHANES Data from 2009-2016
Authors: Ye Kangli , Peng Han , Zhang Xuan , Wang Lefeng , Yang Jian , Hu Mengjie 
Published: December 2024

Abstract

OBJECTIVE
Patients with multimorbidity are at a significantly higher risk of developing depression compared to those without multimorbidity, which can severely impair psychosocial functioning and decrease quality of life. However, no effective method currently exists to assess depression risk in these patients. In this study, we leveraged data from the National Health and Nutrition Examination Survey (NHANES) database and applied machine learning (ML) techniques to construct a depression risk prediction model, aiming to predict the likelihood of depression in patients with multimorbidity.
METHODS
Data from the 2009–2016 NHANES cycles were used, incorporating a wide range of demographic and clinical variables in the analysis. Various machine learning algorithms were evaluated for their predictive performance, and the CatBoost classifier, which demonstrated the best performance, was selected to build the prediction model. The model’s predictions were interpreted using SHapley Additive exPlanations (SHAP) values, which ranked the importance of features and visualized the contribution of variables, such as socioeconomic status, biological factors, and lifestyle habits, in predicting depression among multimorbid patients.
RESULTS
The predictive performance of the model was robust for both overall depression and the binary classification of moderate to severe depression. For moderate to severe depression classification, the model achieved an accuracy of 0.9541, an AUC of 0.9903, and an F1 score of 0.954. The accuracy and recall were 0.9475 and 0.9607, respectively, with a kappa value of 0.9081 and an MCC of 0.9083. SHAP plots revealed that age and socioeconomic status were among the most important predictors for both depression and moderate to severe depression classifications.
CONCLUSION
This study developed a machine learning model to predict depression risk in patients with multimorbidity using NHANES data. The model demonstrated excellent predictive performance, and SHAP plots highlighted key predictors such as age and socioeconomic status, which significantly influenced the prediction of depression and its severity.
Comparative effectiveness of combination therapy of adalimumab and glucocorticoid with glucocorticoid monotherapy in Vogt–Koyanagi–Harada disease
Authors: Chen Tingting , Liu Xiaotong , Li Guodong , Zhang Yingying , Mao Qinglan , Zhan Yurui 
Published: December 2024

Abstract

Purpose: To make a preliminary investigation of the clinical efficacy and safety in treating VKH between adalimumab combined with glucocorticoids and adalimumab alone.
Methods: The medical records of 23 patients with VKH diagnosed were retrospectively analyzed, the GM group received glucocorticoid monotherapy, and the ACWG group received a consolidation of adalimumab subcutaneous injection on top of the conventional treatment in the GM group. The BCVA, and the CMT, as well as the oral hormone dose, recurrence,and adverse events were investigated.
Results: 23 patients (46 eyes) with VKH syndrome were included in this study, 11 males and 12 females. After 3,6 and 10 months of the treatment, the ACWG group significantly improved BCVA compared to the GM group (P<0.05). Compared to pre-treatment, CMT decreased at all time points after treatment in both groups (P<0.05). There was a statistically significant difference in CMT improvement between the two groups after 1 month and 3 months of treatment (P＜0.05). The average steroid dose was reduced significantly in the ACWG group(P＜0.05). A higher recurrence rate was found in the GM group(P=0.046).
Conclusion: The therapy of adalimumab combined with a glucocorticoid is effective and safe, and the recurrence and the burden of oral hormones are also reduced.