bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
Authors: Song Yun-Jeong , Choi In Ah. , Meylan Françoise , Demoruelle M. Kristen , Farley Taylor , Richard Arianne C. , Hawley Eric , Botson John , Hong Yoo Jin , Lee Eun Young , Mian Sabina R. , Hamilton Bartlett C. , Thiele Geoffrey M. , Mikuls Ted R. , Gara Naveen , Ward Chris D. , Lamberth Sarah , Deane Kevin D. , Heller Theo , Ward Michael M. , Lee David M. , Migone Thi-Sau , Stohl William , O’Dell James R. , Norris Jill M. , Holers V. Michael , Gregersen Peter , Song Yeong-Wook , Siegel Richard M. 
Published: May 2020

Abstract
Background
The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationship of TL1A to disease duration, activity, and response to anti-TNF and other therapies in RA is not clear.

Methods
We measured soluble TL1A in synovial fluid (SF), serum, or plasma from RA first-degree relatives (FDRs) and in early RA and established disease. We measured the effects of anti-TNF and methotrexate (MTX) therapy on circulating TL1A from multiple independent RA treatment trials. We also determined the ability of a blocking anti-TL1A antibody to inhibit clinical disease and articular bone destruction in the murine collagen-induced arthritis (CIA) model of human RA.

Results
Soluble TL1A was specifically elevated in the blood and SF of patients with RA compared to patients with other diseases and was elevated early in disease and in at-risk anti-cyclic citrullinated peptide (CCP) (+) first-degree relatives (FDRs). Therapeutic TNF inhibition reduced serum TL1A in both responders and non-responders, whereas TL1A declined following MTX treatment only in responders. In murine CIA, TL1A blockade was clinically efficacious and reduced bone erosions.

Conclusions
TL1A is specifically elevated in RA from early in the disease course and in at-risk FDRs. The decline in TL1A after TNF blockade suggests that TL1A levels may be a useful biomarker for TNF activity in RA. These results support the further investigation of the relationship between TL1A and TNF and TL1A blockade as a potential therapeutic strategy in RA.
Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis
Authors: Koga Tomohiro , Sumiyoshi Remi , Furukawa Kaori , Sato Shuntaro , Migita Kiyoshi , Shimizu Toshimasa , Umeda Masataka , Endo Yushiro , Fukui Shoichi , Kawashiri Shin-ya , Iwamoto Naoki , Ichinose Kunihiro , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Nonaka Fumiaki , Yachie Akihiro , Kondo Hideaki , Maeda Takahiro , Kawakami Atsushi 
Published: May 2020

Abstract
Objective
To identify potential biomarkers to distinguish adult-onset Still’s disease (AOSD) from sepsis.

Method
We recruited 70 patients diagnosed with AOSD according to the Yamaguchi criteria, 22 patients with sepsis, and 118 age-matched controls. Serum levels of 40 cytokines were analyzed using multi-suspension cytokine array. We performed a cluster analysis of each cytokine in the AOSD and sepsis groups in order to identify specific molecular networks. Further, multivariate classification (random forest analysis) and logistic regression analysis were used to rank the cytokines by their importance and determine specific biomarkers for distinguishing AOSD from sepsis.

Results
Seventeen of the 40 cytokines were found to be suitable for further analyses. The serum levels of eleven were significantly higher in patients with AOSD than healthy controls. Levels of serum fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor (G-CSF), and interleukin (IL)-18 were significantly elevated in patients with AOSD compared with those with sepsis, and cytokine clustering patterns differed between these two groups. Multivariate classification followed by logistic regression analysis revealed that measurement of both FGF-2 and IL-18 could distinguish AOSD from sepsis with high accuracy (cutoff value for FGF-2 = 36 pg/mL; IL-18 = 543 pg/mL, sensitivity 100%, specificity 72.2%, accuracy 93.8%).

Conclusion
Determination of FGF-2 and IL-18 levels in combination may represent a biomarker for the differential diagnosis of AOSD from sepsis, based on the measurement of multiple cytokines.
On $\mathcal{I}_{{\theta}_{2}}$-convergence in fuzzy normed spaces
Authors: Türkmen Muhammed Recai 
Published: May 2020

AbstractIn this study, first, lacunary convergence of double sequences is introduced in fuzzy normed spaces, and basic definitions and theorems about lacunary convergence for double sequences are given in fuzzy normed spaces. Then, we introduce the concept of lacunary ideal convergence of double sequences in fuzzy normed spaces, and the relation between lacunary convergence and lacunary ideal convergence is investigated for double sequences in fuzzy normed spaces. Finally, in fuzzy normed spaces, we give the concept of limit point and cluster point for double sequences, and the theorems related to these concepts are given.
Analysis of the role of the interleukins in colon cancer
Authors: Wei Xiyi , Zhang Yuan , Yang Zhou , Sha Yeqin , Pan Yitong , Chen Yusheng , Cai Lei 
Published: May 2020

Abstract
Background
The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients.

Methods
A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. The signaling pathway associated with IL-7 was then investigated using gene enrichment analysis. In addition, subsets of TNM were analyzed in detail and univariate and multivariate COX regression analysis were conducted. Finally, we performed western blotting, immunohistochemistry, cell proliferation and cell apoptosis analysis to examine the expression of IL-7 in patients with intestinal cancer.

Results
The study demonstrated that IL-7 could inhibit the progression of colon cancer. In addition, IL-7 was found to be associated with overall survival (OS) and pathological stage. Further analysis of IL-7 expression with clinical data indicated that IL-7 was a key factor in inhibiting colon cancer progression.

Conclusion
IL-7 was a key factor in inhibiting the progression of colon cancer and was closely related to overall survival.
A controlled pilot trial of a nurse-led intervention (Mini-AFTERc) to manage fear of cancer recurrence in patients affected by breast cancer
Authors: McHale Calum T. , Cruickshank Susanne , Torrens Claire , Armes Jo , Fenlon Deborah , Banks Elspeth , Kelsey Tom , Humphris Gerald M. 
Published: May 2020

Abstract
Background
Fear of cancer recurrence (FCR) is common in people affected by breast cancer. FCR is associated with increased health service and medication use, anxiety, depression and reduced quality of life. Existing interventions for FCR are time and resource intensive, making implementation in a National Health Service (NHS) setting challenging. To effectively manage FCR in current clinical practice, less intensive FCR interventions are required. Mini-AFTERc is a structured 30-min counselling intervention delivered over the telephone and is designed to normalise moderate FCR levels by targeting unhelpful behaviours and misconceptions about cancer recurrence.
This multi-centre non-randomised controlled pilot trial will investigate the feasibility of delivering the Mini-AFTERc intervention, its acceptability and usefulness, in relation to specialist breast cancer nurses (SBCNs) and patients. This protocol describes the rationale, methods and analysis plan for this pilot trial of the Mini-AFTERc intervention in everyday practice.

Methods
This study will run in four breast cancer centres in NHS Scotland, two intervention and two control centres. SBCNs at intervention centres will be trained to deliver the Mini-AFTERc intervention. Female patients who have completed primary breast cancer treatment in the previous 6 months will be screened for moderate FCR (FCR4 score: 10‑14). Participants at intervention centres will receive the Mini-AFTERc intervention within 2 weeks of recruitment. SBCNs will audio record the intervention telephone discussions with participants. Fidelity of intervention implementation will be assessed from audio recordings. All participants will complete three separate follow-up questionnaires assessing changes in FCR, anxiety, depression and quality of life over 3 months. Normalisation process theory (NPT) will form the framework for semi-structured interviews with 20% of patients and all SBCNs. Interviews will explore participants’ experience of the study, acceptability and usefulness of the intervention and factors influencing implementation within clinical practice. The ADePT process will be adopted to systematically problem solve and refine the trial design.

Discussion
Findings will provide evidence for the potential effectiveness, fidelity, acceptability and practicality of the Mini-AFTERc intervention, and will inform the design and development of a large randomised controlled trial (RCT).

Trial registration
ClinicalTrials.gov: NCT0376382. Registered 4th December 2018, https://clinicaltrials.gov/ct2/show/NCT03763825
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?
Authors:   on behalf of the Korean Society of Hypertension, Park Sungha , Lee Hae Young , Cho Eun Joo , Sung Ki Chul , Kim Juhan , Kim Dae-Hee , Ihm Sang-Hyun , Kim Kwang-il , Sohn Il-Suk , Chung Wook-Jin , Kim Hyeon Chang , Ryu Sung Kee , Pyun Wook Bum , Shin Jinho 
Published: May 2020

AbstractAntihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of death in the extremely old subject. During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. Severe Acute Respiratory Syndrome-Coronavirus-1 and 2 viral surface protein is known to attach angiotensin converting enzyme 2 (ACE2) on the cell membrane to facilitate viral entry into the cytoplasm. Despite the theoretical concerns of increased ACE2 expression by Renin-Angiotensin-Aldosterone system (RAS) blockade, there is no evidence that RAS inhibitors are harmful during COVID-19 infection and have in fact been shown to be beneficial in animal studies. Therefore, it is recommended to maintain RAS blockade during the current corona virus pandemic.
Learning about how public involvement strengthens HIV research as a medical student
Authors: Lewis Joseph 
Published: May 2020

Plain English summary
A small medical school research project entitled ‘PPI to strengthen clinical and population health research’ caused me to look at an entirely new field – that of Public and Patient Involvement (PPI). PPI is the development of an active partnership between patients and the public and researchers to work alongside each other not just during trial participation but, at each research step. Internet research and use of materials supplied by my tutors changed my understanding and appreciation for the field of PPI. Coming across the story surrounding gay rights campaigners and development of early PPI inspired me to investigate how it is used it modern studies. It struck me how despite its importance, PPI often went undiscussed in contemporary studies. However, one study named PROUD used and reported PPI in an exemplary fashion in order to combat issues and strengthen the trial. PROUD’s PPI improved study design, safety and advertising as well as providing reassurance in difficult times. It also improved recruitment, dissemination of information and made sure that results and future research fields were relevant. Through PROUD and also my own experiences working with a PPI group I was able to develop an understanding and appreciation for the importance PPI. I write with hope to make my learning available to others.

Abstract
A research project during my third year at medical school introduced me to PPI. PPI is defined as research carried out with or by members of the public rather than to, about or for them. Historical gay rights activists’ involvement in research catalysed developments in PPI before it was widely recognised. A contemporary study, PROUD, used exemplary PPI contributions to tackle these issues and make the study successful. My research project was entitled ‘How did PPI contribute towards the PROUD study & what can be learnt from this?’. This letter aims to answer this question but also include my personal reflections on my work and how I developed an understanding and appreciation for the importance PPI. PubMed and Google were examined, as well as University resources. Correspondence with PROUDs lead investigator also informed this letter. It was found that PROUD’s PPI improved study design, safety and advertising as well as providing reassurance in difficult times. It also improved recruitment, dissemination of information and made sure that results and future research fields were relevant. This allows us to understand and appreciate PPI’s role in research and the provision of healthcare. It is also important to increase discussion and learning around PPI for the future.
Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion
Authors: Earpina Srikanth , McDonough Karen , Yeboah-Awudzi Millicent , Cook Kristina J. , Aggarwal Sita , Losso Jack N. 
Published: May 2020

AbstractGlucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined the effect of ellagic acid, ellagic acid-rich muscadine or amla extract, or urolothin A on inflammation in β cells under glucolipotoxic conditions. Rat NIT-1 β cells were incubated in glucolipotoxic conditions (33.3 mM glucose, 250 μM palmitic acid or 33.3 mM glucose + 250 μM palmitic acid with or without ellagic acid, ellagic acid-rich muscadine or amla extracts standardized to its ellagic acid content, or urolithin A). Inflammatory status was evidenced by ELISA analysis of insulin and IL-1β secretion. Ellagic acid-rich muscadine or amla extracts dose-dependently stimulated insulin secretion and down-regulated IL-1β better than pure ellagic acid, or urolithin A. Urolithin A did not statistically stimulate insulin secretion and did not inhibit IL-1β.
Trans Porn Genealogy beyond the Queer Canon
Authors: Strub Whitney 
Published: May 2020

Abstract
While placing transgender pornography under the sign of queerness has been a necessary feature of queer politics, much of the genealogy of trans porn falls more within the orbit of heteronormative capitalism and was enacted through the problematic figure of the “she-male.” Queer and trans scholars have been eager to seize on the work of queer trans culture workers but less attentive to the pioneering efforts of Kim Christy and Joey Silvera, who occupy complicated positions not entirely commensurate with queerness. Christy emerged out of 1970s transfeminine culture to shape “she-male” pornography as a genre, and longtime straight cisgender hardcore performer Silvera moved to directing in the mid-1990s largely by locating transsexuality within an entirely heteronormative market context. Vexed as they are, these works occupy important places within the genealogy of trans porn, even if often by embodying what queer trans porn imagines itself against.
A Timeline of Our Own
Authors: Greenberg Slava 
Published: May 2020

Abstract
Spectrums: New Gender Movement (2017) is a low-budget, independent documentary web series directed, filmed, and edited by Zohar Melinek Ezra and Afek Testa Launer. Spectrums breaks linear time by delaying progress, jumping back and forth, and mourning and celebrating the past while imagining futures that include trans* and gender-nonconforming bodies. The rapid jump-cuts draw attention to this flawed continuity (in documentary as well as in life) and emphasize the fragility of trans* time. Spectrums’ characters disrupt linearity by wasting time, purposely delaying linear progress in their transitions, being pushed outside “family time,” and even circling back. Spectrums operates on trans* time lines, delaying progress in a loopy present and imagining possible futures from reinvented pasts.
Knowledge of and willingness to promote advanced care planning among oncology nurses in southwest China
Authors: Tang Meng-Yan , Li Xiao-Ling , Shi Zheng-Yan , Fu Wen-Jing 
Published: May 2020

Background: Nurses feature prominently in promoting advance care planning (ACP), but only a limited amount of relevant research has been conducted from the nurses' viewpoint, and little is known about the nurses' knowledge of and their willingness to promote ACP in China. Aims: The aims of this study were to investigate oncology nurses' knowledge of and their willingness to promote ACP, and to explore associated factors. Methods: A multi-centre study was conducted to investigate 350 nurses in the oncology departments of four university hospitals in southwestern China. Cluster sampling was used in data collection, which involved three categories of questionnaires concerning demographic characteristics, knowledge about ACP and willingness to promote ACP. Chi-squared tests and multiple linear regression were employed in data analysis. Results: Some 293 valid questionnaires were collected, among which, 60.1% of respondents never received palliative care education, 89.1% never received training about ACP and 72.7% had not even heard of ACP. Nurses with higher position titles (χ2=18.41, p<0.001) and longer working experience (χ2=12.25, p=0.001) were more likely to have received palliative care education; nurses with higher educational background levels (χ2=12.91, p<0.001), higher position titles (χ2=9.77, p=0.003) and longer working experience (χ2=7.92, p=0.006) were more likely to have learned about ACP; nurses with higher position titles had more access to relevant training (χ2=5.10, p=0.03). Furthermore, whether the nurse had ‘heard about ACP’ (B=3.113, p=0.018) and ‘received training about ACP’ (B=3.894, p=0.04) were both associated with their willingness to promote ACP. Conclusions: The findings of this study indicated that oncology nurses were highly inclined to promote ACP, but limited by their lack of knowledge and understanding of it. Therefore, a systematic and adequate training programme about ACP for nurses is an urgent requirement to effectively enhance the implementation of ACP in China.
SAFER PRACTICES in the COVID-19 pandemic
Authors: Silverston Paul 
Published: May 2020

COVID-19 has created a wave of uncertainty for nurses and healthcare practitioners, with new information on the virus being released constantly. Paul Silverston discusses the assessment of patients with symptoms of COVID-19 and how to reduce the risk of misdiagnosis Errors in diagnosis are relatively common in primary care which often result in serious harm to patients. The majority of these errors are preventable. This article describes a diagnostic error checklist, SAFER PRACTICES, which can be used to help clinicians prepare themselves for consulting in patients with suspected or confirmed COVID-19 disease so that they come to the consultation with the correct medical knowledge, clinical assessment plan and diagnostic reasoning required to reduce the risk of diagnostic error. It can also be used during the consultation to deliver a systematic approach to the prevention and detection of diagnostic errors.
Measles: An overview for practice nurses
Authors: Perry Margaret Ann 
Published: May 2020

Since 2017, the United Kingdom has not been classed as ‘measles free’. Margaret Ann Perry examines measles symptoms, treatment and complications, showing why nurses should encourage vaccine uptake This article will give an overview of measles, its symptoms, treatment and complications. Although rare, complications do still occur and can be fatal. Vaccination is the key to preventing this disease and the article therefore aims to raise awareness of potentially serious complications and will give nurses confidence in encouraging vaccine uptake among their patient population.
The potency of endophytic bacteria isolated from Ficus septica as phytoremediation promoting agent of Cr (VI) contaminated soil
Authors: Nita Shilfiani Rohmah Nita Shilfiani Rohmah , SUHARJONO  , YOGA DWI JATMIKO  , DIAN SISWANTO  , IRFAN MUSTAFA  
Published: May 2020

Abstract. Rohmah NS, Suharjono, Jatmiko YD, Siswanto D, Mustafa I. 2020. The potency of endophytic bacteria isolated from Ficus septica as phytoremediation promoting agent of Cr (VI) contaminated soil. Biodiversitas 21: 1920-1927. Endophytic bacteria tolerant of chromium have the potential to reduce Cr (VI) to Cr (III) and produce compounds that can improve plant survival in Cr (VI) contaminated soils. This study was performed to isolate and identify Cr (VI)-tolerant bacteria from the endosphere of Ficus septica Burm.F growing on the tannery waste contaminated soil, Screening of bacteria was carried out based on the level of Cr (VI) tolerance. High tolerant isolates were tested for their potential of Indole Acetic Acid (IAA) and exopolysaccharide (EPS) production, phosphate solubilizing, and the presence of chromate reductase (ChR) genes. The most potential bacterial isolate was identified based on 16S rDNA sequences. The results showed that three isolates (E3, E4, and E8) were tolerant of Cr (VI) up to 900 mg/L. E8 isolates produced the highest IAA production (20.05 μg/mL), phosphate solubilization (127.78 μg/mL), and EPS production (9,70 μg/mL), and all isolates had the ChR gene. E8 isolate was found to be 100% identical to Enterobacter cloacae ATCC 13047.