bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats
Authors: ZAİMOĞLU Ayşenur , AKYÜZ Bahar , BİLGE S. Sırrı 
Published: October 2019

Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopram, one of the most prescribed antidepressants, on developmental characteristics, reflex and motor functions of rat pups. Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were used in the experiments. Rats were divided into 3 groups and separated into individual cag-es. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric ga-vage from gestational days 1 to 18, control group received the same amount of saline (2 ml/kg/d). After birth duration of gestation, number of live and dead pups and gross malformation are evaluated. Eye opening, pinna detachment, incisor eruption, the development of fur and weight gain were monitored as developmental parameters. Markers for reflex development were identified as righting reflex, negative geotaxis and grip response. Motor developments and cognitive functions were established with locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test. Results: Developmental parameters, reflex, motor and cognitive development as-sessments of pups were not significantly different in treatment groups compared to control group. Conclusion: The results of the study show that prenatal exposure to citalopram has no effect on motor and cognitive functions of rat offspring.
The Role of Arthroscopic Decompression in Subacromial Impingement Syndrome
Authors: ATİK Aziz 
Published: October 2019

Aim: The aim of this study was to evaluate the clinical results of patients who had arthroscopic subacromial decompression for the diagnosis of subacromial impingement syndrome which is characterized by compression of the coracoacromial arc on rotator cuff tendons. Patients and Methods: We have evaluated the Constant scores, rest VAS and motion VAS scores of 25 patients who had arthroscopic subacromial decompression after six months of failed conservative treatment, at the preoperative day, 15th day and 6th month after the operation. Results: There was a statistically significant difference between pre-operative and 15th day / 6th month scores with Mann Whitney U test (p &lt;0.0001). We found that the patients’ pain decreased and shoulder functions improved statistically. Conclusion: We believe that the choice of treatment for early stages of subacromial impingement syndrome is conservative, but if complaints persist even six months after conservative treatment, then arthroscopic subacromial decompression is a good choice of treatment.
Eklem Hastalıkları ve Cerrahisi Dergisinin Bibliometrik Analizi: Bölüm-1: SCI-E öncesi dönem
Authors: ASLAN Ahmet 
Published: October 2019

Amaç: Bibliyometrik analizler; bilimsel dergilerin iç değerlendirilmesinin yapılması ve etki değerinin arttırılmasına yönelik editöryal politikaların belirlenmesi açısından önemlidir. Bu makalede Eklem Hastalıkları ve Cerrahisi (EHC) Dergisinin bibliyometrik verilerin tanımlanması ve atıf almasını etkileyen faktörler araştırılmıştır. Gereç ve Yöntem: Retrospektif bibliyometrik olarak dizayn edilen bu çalışmada: Yayımlandığı ilk sayısından bu yana 30 yılık süreçteki EHC tüm makaleleri gözden geçirildi. Çalışmanın bu ilk bölümünde SCI-E öncesi dönem araştırıldı. Makalelerin yazar, kurum, çeşit ve konu özellikleri değerlendirildi. Atıf almayı etkileyen faktörler analiz edildi. Kategorik veriler için ki-kare, sayısal veriler için Anova testi ve posthoc karşılaştırmada t testi kullanıldı. Bulgular: Değerlendirilen toplam 688 makaleden 134 ü (%19,5) en az bir atıf almıştır. Bu çalışmada atıf almayı etkileyen en önemli faktör; makalelerin tam metinine internetten ulaşılabilmesi olmuştur (p&lt;0,01). Ayrıca makale dili de atıf almada anlamlı bulundu (p=0,026). Makale başına ortalama yazar sayısı 3,8 ve atıf sayısı 0,7 olarak bulundu. Makalelerin en çok Üniversitelerden gönderildiği tespit edildi. Sonuç: Bilimsel bir derginin gelişim süreci içerisinde bazı mesafeler kat etmesi gerekmektedi. Dergide yayımlanan makalelerin tam metinlerine web ortamında erişilebilir olması, atıf almada önemli bir etkendir. Ayrıca özgün araştırma ve derleme türü makalelerin daha çok atıf alabileceği değerlendirilmiştir. Bununla birlikte iyi seçilmiş bir olgu sunumu da atıf alabilir. Son olarak uluslararası atıf açısından yurtdışı ve İngilizce makaleler avantajlı olabilir.
CUMHURİYET DÖNEMİ TÜTÜN VE SİGARA KAÇAKÇILIĞI BAĞLAMINDA SURİYE SINIR GÜVENLİĞİNE BAKIŞ (1923-1940)
Authors: BORLAT Barış 
Published: October 2019

Tütünün Osmanlı Devletine girişi ve kârlı bir tarım ürünü
olarak görülmesi kaçakçılığı da beraberinde getirmiştir. Osmanlı Devleti tütün
tarımında, Avrupalı devletlerin denetimiyle birlikte kaçakçılığın çözümü için
silahlı önlemler başta olmak üzere değişik politikalar geliştirilmiştir. Ancak
sorunun çözümüne yüzeysel olarak bakıldığı için çözümden öte yeni sorunları da
ortaya çıkarmıştır.

Cumhuriyet döneminde tütün tarımının geliştirilmesi, milli
ekonomi politikaları içerisinde yer aldığı için kaçakçılık sorununun çözümü de
önemli konular arasında görülmüştür. Ancak devletin ekonomik gücüyle orantılı
olarak geliştirilebilen sınır güvenliği sorunu kısa vadede çözülememiştir. Bu
durum Türkiye’de sınır kaçakçılığını ve kârlı görülen bu uğraştan faydalanmak
isteyen grupları ortaya çıkarmıştır. Kaçakçılık yapan kişilerin bunun dışında
diğer yasa dışı oluşum ve eylemlerde de bulunması yaygın bir kullanıma sahip
olan tütün kaçakçılığını ön plana çıkarmıştır.

Kaçakçılar zamanla kendilerine has yöntemler geliştirmekle
birlikte, bu tecrübelerini etrafına, yoğun olarak da ailesine aktararak bu
olguyu gelenekselleştirmiştir. Sorunun en önemli boyutu ise kaçakçılık ve
eşkıyalık yaklaşımlarının paralel olarak ilerlemesidir.

Atatürk Dönemi Tütün ve Sigara Kaçakçılığı (1923-1938)
başlıklı tez çalışmamdan genişleterek hazırlamış olduğum makalemde kaçakçılık,
kaçakçılık güzergâhları, kaçakçıların profilleri, eşkıyalığın kaçakçılığa
etkileri ve sorunun çözüm arayışları incelenmeye çalışılmıştır.
Türk Sigortacılık Sektörünün 2007-2018 Yıllarına Ait Performansının Oran Analizi Yöntemi ile Ölçülmesi ve Sektörün Ekonomik Büyüme Üzerindeki Etkisi
Authors: HAYIRSEVER BAŞTÜRK Feride 
Published: October 2019

Araştırmada, finansal aracılık görevini gören sigorta sektörünün
performansının ölçülmesi ve ekonomik büyüme üzerindeki etkisinin incelenmesi
amaçlanmıştır. İlk olarak Türk Sigortacılık Sektörünün 2007-2018 yılları
arasındaki performansı oran analizi yöntemi ile değerlendirilmiş, ikinci olarak
Türkiye’de üretilen toplam primler ile GSYH arasındaki ilişki incelenmiştir.
Sigorta şirketlerinde finansal analizin amacı, şirketlerin finansal yapısının
dayanıklılığının saptanmasıdır. Sigorta şirketlerinin aktif kaliteleri ödeme
gücünün yeterliliği açısından oldukça önemlidir. Sigorta şirketlerinin
aktifleri bir yandan getiri sağlarken bir yandan da nakit ihtiyacını
karşılayabilecek likidite yapısında olmalıdır. Hayat dışı branşlarda aktif
kalitesi ve likidite oranları olması gereken seviyenin altında iken, hayat
branşında ise yeterli düzeydedir. Hayat dışı branşta Muallak Hasar Karşılıkları
hasar prim oranının artmasına sebep olmuştur. Bileşik oran, hayat dışı branşta
hayat branşından daha yüksek olarak görülmektedir. Teknik karşılık oranlarında sektör
genelinde büyük bir sorun gözükmese de, hayat dışı branşta özellikle
özsermaye/teknik karşılık oranının hayat branşına göre daha yüksek seyrettiği
görülmektedir. Ayrıca toplam primler ile ekonomik
büyüme arasında pozitif yönlü bir ilişkinin söz konusu olduğu gözlemlenmiştir.
Événements indésirables au cours de transfert interhospitalier de patients présentant un syndrome coronaire aigu non ST+
Authors: Lenglet A. , Balen F. , Charpentier S. , Sourbes A. , Arcuset D. , Delonglée V. , Fort P.A. , Bounes V. , Dadone B. Charriton 
Published: October 2019

Introduction : Cette étude a pour objectif de connaître l’incidence et la nature des événements indésirables (EI) se produisant lors des transports interhospitaliers (TIH) des patients souffrant d’un syndrome coronarien aigu sans sus-décalage du segment ST (SCA non ST+). L’objectif secondaire est d’étudier les performances pronostiques des différentes évaluations de risque existantes de ces malades (score de GRACE, score de TIMI, grille de Fiancette et niveau de risque de la Société européenne de cardiologie [ESC]) dans la prédiction de ces EI.
Méthode : Il s’agit d’une étude de cohorte multicentrique rétrospective. Du 1er novembre 2016 au 31 octobre 2017, les patients SCA non ST+ et bénéficiant d’un transport secondaire ont été inclus à partir des fiches de régulation de trois Samu du sud-ouest de la France. Les types d’EI ont été recueillis. Les différents scores ont été calculés pour chaque patient ainsi que leur performance pronostique (sensibilité, spécificité, valeurs prédictives positives [VPP] et négatives [VPN]).
Résultats : Sur un an, 315 patients ont été inclus, et neuf patients (3 % ; IC 95 % : 1,3–5,3) ont présenté un EI. Soixante-dix-huit pour cent des événements recueillis n’ont pas engagé le pronostic vital des patients, et 40 % n’ont pas nécessité d’intervention thérapeutique nécessitant la présence physique d’un médecin. Aucun score n’est retrouvé statistiquement significatif dans la prédiction des EI. Toutefois, la stratification du risque de la ESC semble être la plus simple d’utilisation tout en assurant une valeur prédictive négative de 98 % (IC 95 % : 94–99).
Conclusion : Il y a peu d’EI lors du transport des SCA non ST+. L’utilisation en régulation de l’évaluation du risque ischémique de la ESC pourrait réduire la surmédicalisation de ces malades au bénéfice des TIH.
RANCANG BANGUN SISTEM MONITORING DETAK JANTUNG MENGGUNAKAN ELEKTROKARDIOGRAF BERBASIS BLUETOOTH DAN LABVIEW
Authors: Alam Syah , Hartanto Sri , Pratama Ikbal 
Published: October 2019

Elektrokardiograf (EKG) adalah alat yang digunakan untuk mendeteksi detak jantung pada manusia yang biasa digunakan di rumah sakit khususnya pada ruang ICU. Pada umumnya alat EKG dikendalikan secara manual menggunakan medium kabel sehingga memiliki keterbatasan jarak dan akses untuk melakukan monitoring. Penelitian ini mengusulkan rancang bangun prototype alat monitoring detak jantung pada manusia dengan berbasis arduino dan labview yang dikomunikasikan menggunakan Bluetooth agar dapat diakases secara efektif menggunakan wireless. Perancangan dilakukan menggunakan sensor elektroda yang dihubungkan dengan penguat awal, band pass filter, penguat akhir, rangkaian clamper dan arduino uno yang dihubungkan dengan modul bluetooth serial HC-05 dan dapat dimonitor menggunakan labview menggunakan Personal Computer (PC). Dari hasil pengujian dan pengukuran, diperoleh jarak maksimal monitoring adalah 5 meter dengan tanpa halangan serta tingkat keakuratan detak jantung 96.1 % jika dibandingkan dengan detak jantung yang di deteksi dari nadi manusia. Hasil ini menunjukkan bahwa prototype yang diusulkan dapat bekerja dengan baik dan memenuhi syarat untuk dapat diaplikasikan pada sistem pendeketsi detak jantung manusia menggunakan elektrokardiograf.
Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort
Authors: Nakanishi Miharu , Yamasaki Syudo , Nishida Atsushi , Richards Marcus 
Published: October 2019

Background: There is growing interest in public health strategies to modify dementia risk in midlife to reduce the burden of cognitive impairment in subsequent decades. Risk reduction messages should include key recommendations for women in response to the high prevalence of dementia observed in this population. Midlife is a critical period for dementia-related brain changes and psychosocial crises. Psychological well-being can improve resilience to crises, yet it is not well understood with respect to dementia risk reduction. Objective: This study aimed to examine the association between midlife psychological well-being and cognitive function in later life in women. Methods: The study included 703 women from the British 1946 birth cohort in the Medical Research Council’s National Survey of Health and Development. Psychological well-being at 52 years was assessed using the Ryff Scales of Psychological Well-being over six dimensions: autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance. Cognitive function at 69 years was measured using the Addenbrooke’s Cognitive Examination, Third Edition. Results: After controlling for cognitive ability at eight years, educational attainment by 26 years, occupational attainment and marital status by 53 years, depression, smoking, and physical exercise at 60–64 years, there was a significant association between greater personal growth and lower self-acceptance at 52 years, and better cognition at 69 years. However, there was no association between cognition and the other four Ryff scales. Conclusion: Most aspects of midlife psychological well-being, except for personal growth and self-acceptance, were not prospectively associated with cognition.
Plasma Neurofilament Light Chain in Primary Progressive Aphasia and Related Disorders: Clinical Significance and Metabolic Correlates
Authors: Matías-Guiu Jordi A. , Gómez-Pinedo Ulises , Forero Lucía , Pytel Vanesa , Cano Fátima , Moreno-Ramos Teresa , Cabrera-Martín María Nieves , Matías-Guiu Jorge , González-Rosa Javier J. 
Published: October 2019

Background: Primary progressive aphasia (PPA) is a heterogeneous syndrome that is difficult to diagnose at early stages. Plasma neurofilament light chain (NFL) has been proposed as a potential biomarker for PPA. Objective: To examine the diagnostic properties of plasma NFL in PPA and to evaluate its association with clinical stages of the disease and brain metabolism. Methods: Our study included 80 participants (13 with non-fluent, 12 with semantic, and 16 with logopenic variant PPA; 13 with amnestic Alzheimer’s disease [AD]; 13 with behavioral variant frontotemporal dementia; and 13 healthy controls). Plasma NFL concentration was measured using a high-sensitivity enzyme-linked immunosorbent assay (ELISA) kit. PET imaging was performed in a subgroup of patients. Results: NFL discriminated patients from controls with an area under the curve of 0.914 (95% CI, 0.843–0.984; p < 0.001) (cut-off: 76.46 pg/mL; 94% sensitivity, 76.9% specificity). There were no significant differences between clinical syndromes (PPA subtypes), the main clinical forms of dementia (frontotemporal dementia and AD), or the expected pathological groups (frontotemporal lobar degeneration-tau [FTLD-tau], FTLD-TDP43, and AD). NFL levels showed weak to moderate correlations with age and functional scale score. We found no significant correlation with the extent of hypometabolism observed on FDG-PET images. Conclusion: Plasma NFL is a non-specific marker of neurodegeneration, and may be helpful in the diagnosis of PPA. However, NFL does not permit differential diagnosis between PPA subtypes and is not correlated with the extent of neurodegeneration.
Radiomics study for differentiating gastric cancer from gastric stromal tumor based on contrast-enhanced CT images
Authors: Sun Zong-Qiong , Hu Shu-Dong , Li Jie , Wang Teng , Duan Shao-Feng , Wang Jun 
Published: October 2019

PURPOSE: To test the feasibility of differentiate gastric cancer from gastric stromal tumor using a radiomics study based on contrast-enhanced CT images. MATERIALS AND METHODS: The contrast-enhanced CT image data of 60 patients with gastric cancer and 40 patients with gastric stromal tumor confirmed by postoperative pathology were retrospectively analyzed. First, CT images were read by two senior radiologists to acquire subjective CT signs model, including perigastric fatty infiltration, perigastric enlarged lymph nodes, the enhancement and growth modes of gastric tumors. Second, the manual segmentation of gastric tumors from the CT images was performed by the two radiologists to extract radiomics features via ITK-SNAP software, and to construct radiomics signature model. Finally, a diagnostic model integrated with subjective CT signs and radiomics signatures was constructed. The diagnostic efficacy of three models in differentiating gastric cancer from gastric stromal tumor was compared by using receiver operating characteristic curves (ROC). RESULTS: There are statistically significant differences between the gastric cancer and gastric stromal tumor in the perigastric enlarged lymph nodes, growth mode and radiomics signature ( p < 0.05). The area under ROC curve (AUC), sensitivity and accuracy of subjective CT signs model were the lowest among the three models. While the combined model yields the highest AUC value (0.903), specificity (93.33%) and accuracy (86.00%) among the three models ( p = 0.03). CONCLUSION: The diagnostic model integrating subjective CT signs and radiomics signature can improve the diagnostic accuracy of gastric tumors.
Design and Performance Test of Rubber Grinding Machine
Authors: Novita Sri Aulia , Hendra Hendra , Jamaluddin Jamaluddin , Makky Muhammad , Fahmi Khandra 
Published: October 2019

The quality of rubber processed materials, that is produced by the farmer is generally low and can be seen from their colour, pollutants levels, foul odour and the very cheap price. To improve the quality of the rubber should be done both in terms of its treatment and processing equipment. The main objective of this research is to enhance and improve the quality of farmer's rubber processed materials by using natural coagulant which liquid smoke to agglomerate the rubber, and designing of rubber grinding machine. The component of rubber grinding machine including hopper, regulating entry materials, three rollers, pulleys and belt, outlet, gears, engine, regulating the thickness and chassis. In this research, the thickness rubber after grinding is 3-5 mm accordance with Indonesian National Standard rubber. Processed material rubber produced is white and no pollutants. The coagulant used was liquid smoke with a concentration of 10 -20%, where this addition affects the agglomeration speed of rubber and smelled slightly of smoke. The average rate of Feed is 48.58 kg / h, a capacity of the machine is 37.40 kg/hr and cost of operation is Rp. 650 / kg.
ION CHROMATOGRAPHY METHOD FOR DETERMINATION OF ISOPROPYLAMINE CONTENT IN METOPROLOL SUCCINATE
Authors: More Rohan , Gosar Dr. Amit , Shaikh Dr. Tabrez , Joglekar Amit 
Published: October 2019

A simple, sensitive, specific, linear and effective Ion chromatography method has been developed and validated for the determination of Isopropylamine content in Metoprolol Succinate. Isopropylamine is possible impurity that may be present in Metoprolol succinate samples. The method was validated as per International Council for Harmonisation (ICH) guidelines, for which limit of detection and limit of quantitation obtained were 29 ppm and 87 ppm respectively. % RSD for System precision observed was 1.38. The regression coefficient found for the linearity study was 0.9997. The % recovery of the spiked Isopropylamine in drug substance obtained was in the range of 83.2 to 100.7 from 50 % to 150 % level ensured the accuracy of the method. The method can be adapted to determine Isopropylamine content in Metoprolol Succinate drug substance (API).
Keywords: Ion chromatography (IC), Metoprolol Succinate, Isopropylamine, development, validation.
ВПЛИВ ІНОЗЕМНОГО КАПІТАЛУ НА БАНКІВСЬКУ СИСТЕМУ УКРАЇНИ В УМОВАХ ГЛОБАЛІЗАЦІЇ
Authors: Татар М. С. , Нужнова Ю. А. , Рябус К. М. 
Published: October 2019

Formulation of the problem. In the last five years the number of insolvent banking institutions was reduced, however, the percentage of banks with foreign capital in the total number of banks was increased, which may affect the banking system stability and require a research of the positive and negative effects of foreign banks on Ukraine banking system. The aim of the research is analizing trends of the foreign capital presence in Ukraine banking sector and determination its positive and negative impact on Ukraine banking system. The subject of the research is the activity of foreign banks in Ukraine. The methods of the research: logical and meaningful method, method of comparison, methods of induction and deduction, etc. The hypothesis of the research. Existence of significant influence of foreign capital on Ukraine banking system. The statement of basic materials. The main tendencies of development of Ukrainian banks and place in ratings of state-owned banks and banks of foreign banking groups are analyzed. It has been found that according to different ratings, banks of foreign banking groups occupy the first leading five positions in the rating, while banks with state-owned shares occupy mostly middle positions. The positive and negative influence of the presence of foreign banks in the territory of Ukraine on the banking system of Ukraine is analyzed. The originality and practical significance of the research is determination the positive and negative impact of foreign capital banks on Ukraine banking system. Conclusions and perspectives of further research. Positive and negative influence of presence of foreign capital banks on the Ukraine banking system is analyzed, which is the basis for further research, in which it is planned to quantify the power of influence of individual banks with foreign capital on Ukraine banking system development, to determine the effectiveness of attracting foreign banking capital in Ukraine, to form a mechanism for admission of banks with foreign capital to the domestic banking services market.
PENENTUAN KONDISI KESEIMBANGAN UNIT LEACHING PADA PRODUKSI EUGENOL DARI DAUN CENGKEH
Authors: Tagora Bangkit P.S  , Rinaldry Sirait  , Iriany  
Published: October 2019

Leafs of clove is an alternative source to obtain clove oil. Clove oil is classified into essential oil with eugenol as its main component. Clove oil is widely used in pharmaceutical, food and beverage industries. The objective of this research is to obtain clove oil by solid-liquid extraction (leaching). This research was expected to give data of solid-liquid equilibrium for designing solid liquid extractor. This research was carried out by leaching process with ethanol as its solvent. The extract was then purified by distillation to separate solvent from oil. The fixed variables which were used in this research were stirring rate of 460 rpm and 90 grams dry-based clove leaf. Extraction process was carried out by using solvent with temperature of 30oC and 50oC, extraction time of 1-3 hours with 0.5 hour increment and solvent volume of 500 ml and 600 ml. The results showed that the highest yield of clove oil extraction was obtained at temperature of 50oC and solvent volume of 600 ml. Equilibrium was reached after 2.5 hours and 79% eugenol concentration in the solvent.