bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of plot and sample sizes on aboveground biomass estimations in plantation forests using very high resolution stereo satellite imagery
Authors: Hosseini Zahra , Latifi Hooman , Naghavi Hamed , Bakhtiarvand Bakhtiari Siavash , Fassnacht Fabian Ewald 
Published: June 2020

AbstractRegular biomass estimations for natural and plantation forests are important to support sustainable forestry and to calculate carbon-related statistics. The application of remote sensing data to estimate biomass of forests has been amply demonstrated but there is still space for increasing the efficiency of current approaches. Here, we investigated the influence of field plot and sample sizes on the accuracy of random forest models trained with information derived from Pléiades very high resolution (VHR) stereo images applied to plantation forests in an arid environment. We collected field data at 311 locations with three different plot area sizes (100, 300 and 500 m2). In two experiments, we demonstrate how plot and sample sizes influence the accuracy of biomass estimation models. In the first experiment, we compared model accuracies obtained with varying plot sizes but constant number of samples. In the second experiment, we fixed the total area to be sampled to account for the additional effort to collect large field plots. Our results for the first experiment show that model performance metrics Spearman’s r, RMSErel and RMSEnor improve from 0.61, 0.70 and 0.36 at a sample size of 24–0.79, 0.51 and 0.15 at a sample size of 192, respectively. In the second experiment, highest accuracies were obtained with a plot size of 100 m2 (most samples) with Spearman’s r = 0.77, RMSErel = 0.59 and RMSEnor = 0.15. Results from an analysis of variance type-II suggest that the overall most important factors to explain model performance metrics for our biomass models is sample size. Our results suggest no clear advantage for any plot size to reach accurate biomass estimates using VHR stereo imagery in plantations. This is an important finding, which partly contradicts the suggestions of earlier studies but requires validation for other forest types and remote sensing data types (e.g. LiDAR).
Targeted Deletion of Interleukin-6 in a Mouse Model of Chronic Inflammation Demonstrates Opposing Roles in Aging: Benefit and Harm
Authors: Ma Lina , Nidadavolu Lolita S , Yang Huanle , Langdon Jackie , Westbrook Reyhan , Tsui Benjamin M W , Lee Taek-Soo , Hinson Jared , Ling Shizhang , Marx-Rattner Ruth , Wu Yuqiong , Nguyen Tu , Tan Jessica , Khadeer Mohammed , Moaddel Ruin , Le Anne , Walston Jeremy D , Abadir Peter M 
Published: June 2020

Abstract
Chronic inflammation (CI) in older adults is associated with reduced health span and life span. Interleukin-6 (IL-6) is one CI marker that is strongly associated with adverse health outcomes and mortality in aging. We have previously characterized a mouse model of frailty and chronic inflammatory pathway activation (IL-10tm/tm, IL-10 KO) that demonstrates the upregulation of numerous proinflammatory cytokines, including IL-6. We sought to identify a more specific role for IL-6 within the context of CI and aging and developed a mouse with targeted deletion of both IL-10 and IL-6 (IL-10tm/tm/IL-6tm/tm, DKO). Phenotypic characteristics, cytokine measurements, cardiac myocardial oxygen consumption, physical function, and survival were measured in DKO mice and compared to age- and gender-matched IL-10 KO and wild-type mice. Our findings demonstrate that selective knockdown of IL-6 in a frail mouse with CI resulted in the reversal of some of the CI-associated changes. We observed increased protective mitochondrial-associated lipid metabolites, decreased cardiac oxaloacetic acid, improved myocardial oxidative metabolism, and better short-term functional performance in DKO mice. However, the DKO mice also demonstrated higher mortality. This work shows the pleiotropic effects of IL-6 on aging and frailty.
Present-day deformation in the Upper Rhine Graben from GNSS data
Authors: Henrion Eric , Masson Frédéric , Doubre Cécile , Ulrich Patrice , Meghraoui Mustapha 
Published: June 2020

ABSTRACT
The Upper Rhine Graben (URG) undergoes continuous microseismicity recorded by seismic monitoring networks and moderate-magnitude earthquakes, such as in the zone north of the Alpine front, which includes the Jura thrust front, the Vosges, the Black Forest, the Swabian Jura and the Alsace plain. The surface velocity field is a good indication of the occurrence and location of strain gradients likely associated with seismogenic structures. To explore that possibility, we use long time-series of displacements measured from 2002 to 2018 with the dense GURN network (GNSS URG Network). The processing based on double differences of phase measurements offers an up-to-date surface velocity field of the URG and surrounding areas. The surface velocity field relative to the Eurasia reference frame (ITR2014) points out some areas where coherent movements are present for groups of stations. The heterogeneous velocity field across the Rhine Graben (Vosges, URG, Black Forest and Swabian Jura) displays velocity values below 0.2 mm yr−1. We compute a deformation field from the GNSS velocities to link the deformation to the spatial distribution of earthquakes in the Rhine Graben. The earthquakes are concentrated south of an east–west line passing through Strasbourg to the Alpine front. Instrumental and historical seismicity presents spatial similarities in the Vosges and Swabian Jura. Considering the consistent northward movement observed in the Alpine front, we suggest that the strong seismicity in the south of the URG is caused by the shortening of the Alps. North of the URG, the seismicity is more dispersed where the velocity field does not show coherent movements.
Females as the Gatekeepers to Seasonal Breeding: What We Can Learn by Studying Reproductive Mechanisms in Both Sexes
Authors: Kimmitt Abigail A 
Published: June 2020

Synopsis
Seasonal reproduction is a widespread adaptation in vertebrates, such that individuals time their reproductive efforts to match peak resource abundance. Individuals rely on environmental cues to regulate hormonal mechanisms governing timing of breeding. Historically, studies on physiological mechanisms of seasonal reproduction, specifically in birds, have disproportionately focused on males compared to females. For this review, I conducted a literature search of the last decade of avian research and found a persistent sex bias in the field of physiological mechanisms of seasonal reproduction. Using work conducted with the dark-eyed junco (Junco hyemalis) as a case study, I present a possible solution to combat the sex bias: natural comparisons of populations that differ in reproductive timing to investigate mechanisms of reproduction in both sexes. Populations of dark-eyed juncos that differ in migratory behavior (i.e., migrant and resident) exhibit overlapping ranges during winter and early spring; residents begin breeding in early spring prior to the departure of migrants. This system, and others like it, provides an opportunity to compare mechanisms of reproduction in populations that differ in reproductive timing despite experiencing the same environmental conditions in early spring. In juncos, migrant and resident females and males exhibit similar patterns of hypothalamic regulation of reproduction in early spring, but sex differences in gonadal sensitivity between the populations could be an important distinction that partially explains sex differences in reproductive development. Comparing mechanisms of reproduction in free-living populations and in captivity can reveal important mechanisms that determine the onset of reproductive development, as well as potential sex differences in these mechanisms. Understanding the mechanisms of reproductive phenology has important implications for understanding how species will survive and reproduce in a changing climate.
Northwest Atlantic mackerel population structure evaluated using otolith δ18O composition
Authors: Redding S Gray , Cooper L W , Castonguay M , Wiernicki C , Secor D H 
Published: June 2020

AbstractThe Northwest Atlantic mackerel (Scomber scombrus) population is comprised of northern and southern contingents, each with distinct natal regions in the United States and Canada. We tested hypotheses on natal origin and contingent mixing by analysing natal otolith δ18O values, evaluating the approach through an out-group comparison with the Northeast Atlantic population. Otolith δ18O values varied according to expectations between the Northeast (higher) and the Northwest (lower) Atlantic basins, and between contingents within the Northwest Atlantic stock, although contingent differences varied between years. Most adults (age-3+ years) sampled from US waters (1999–2003) represented the northern contingent (Canadian spawning site). The confirmation of the seasonal mixing of older and larger fish between the two contingents provides support and justification for the development of bi-national (United States–Canada) assessment and management of Northwest Atlantic mackerel.
Cormorant (Phalacrocorax carbo) predation on a coastal perch (Perca fluviatilis) population: estimated effects based on PIT tag mark-recapture experiment
Authors: Veneranta L , Heikinheimo O , Marjomäki T J 
Published: June 2020

Abstract
The number of cormorants has rapidly increased in the northernmost Baltic Sea. In 2018, 50 km × 50 km ICES catch rectangle 55H1 had 3140 breeding pairs. To estimate the predation effect of cormorants on perch populations, we Passive Integrated Tags tagged 1977 perch and 9.9% of tags were found. The median instantaneous cormorant-induced mortality during the breeding time, with consumption by non-breeding individuals, was estimated at 0.23 and at 0.35 during the whole residing period. We estimated with a yeild-per-recruit model that the long-term maximum loss of perch yield of tagged sub-population would be at 80% probability interval 32–67%, and when extended to the entire 55H1, 10–33%, respectively. The cormorants’ share of the &gt;2-year-old perch biomass and production would be 8%, while that of other natural mortality would be 63% and that of fishing 29% in 55H1. The yield-per-recruit-results should be interpreted as an estimate of maximum cormorant effect because the dependence of predation rate on prey density was not accounted for, and density-dependence of growth, mortality, and reproduction of perch could partly compensate the loss. The results indicate that high density of cormorants can reduce the perch stocks and catches locally.
The Status of the Testimony of the Non-Appearing Witness in International Arbitration
Authors: Brown Chester , Still Patrick 
Published: June 2020

Abstract
A problem that arises from time to time in international arbitration proceedings is how an arbitral tribunal is to deal with the evidence of a non-appearing witness. The applicable rules of arbitration typically confirm that the tribunal has the authority to determine (e.g.) the “admissibility, relevance, materiality and weight of the evidence offered,” but they rarely go any further than this. The purpose of this article is to seek to provide guidance to tribunals by reviewing the available arbitral practice. This reveals that there are circumstances in which tribunals have adopted broadly consistent approaches to the status of the non-appearing witness's written testimony (although this does not appear to extend to the treatment of a non-appearing expert's evidence), and that tribunals have generally not distinguished between the existence of a valid reason for a witness's failure to appear, or of exceptional circumstances which would warrant the witness's evidence being admitted. In addition, tribunals appear to be reluctant to place much weight on a non-appearing witness's written evidence unless it is corroborated by the testimony of other witnesses or documentary evidence, and they are also reluctant to draw adverse inferences from a witness's non-appearance.
Experimental studies on corrosion inhibition performance of acetylthiophene thiosemicarbazone for mild steel in HCl complemented with DFT investigation
Authors: Al-Baghdadi S , Gaaz T S , Al-Adili A , Al-Amiery A A , Takriff M S 
Published: June 2020

AbstractThe University of Technology in Baghdad addresses problems related to the corrosion of metals. In the present investigation, a thiophene derivative, namely, 2-acetylthiophene thiosemicarbazone (2-AT), was synthesized and examined as a corrosion inhibitor for mild steel in a 1-M hydrochloric acid environment by using weight loss and scanning electron microscopic techniques. The inhibition efficiency of this inhibitor increases with increase in concentration, which offered an inhibition efficiency up to 96%. It was found that the inhibition efficiency decreases with long immersion time. The temperature effect on the inhibition performance was studied at various immersion times and revealed that the inhibition efficiency decreases with increasing temperature. The adsorption of the inhibitor on the surface of mild steel in the corrosive environment followed the Langmuir isotherm. The results of scanning electron microscopy (SEM) reveal that the 2-AT molecules confirmed the presence of a protective layer on the surface of a mild steel sample. The density-functional theory as a quantum modeling technique which is used to study the electronic structure reveals that the obtained findings were found to be consistent with the experimental results.
Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly
Authors: Anderson Denise , Neri João I C F , Souza Cássio R M , Valverde Joanna G , De Araújo Josélio M G , Nascimento Maria D S B , Branco Rebeca C C , Arrais Nivia M R , Lassmann Timo , Blackwell Jenefer M , Jeronimo Selma M B 
Published: June 2020

Abstract
The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.
Opportunity for Real-Time, Longitudinal Clinical Laboratory Data to Enhance Diabetes Disease Surveillance: A Cross-Sectional, Laboratory Database–Enabled Population Study
Authors: Borunda Duque Teofilo , Dodd Monique , Mwithi Andrew , VanNess Richard , Swanson Kathleen 
Published: June 2020

Abstract

Background
Population disease surveillance can contribute to focused interventions to promote better disease management and prevention of noncommunicable diseases.

Methods
HbA1c results in TriCore Reference Laboratories’ (TriCore) data repository from residents in New Mexico (NM) from January 2014 to May 2019 were used in the study. Using the Behavioral Risk Factor Surveillance System (BRFSS) as the gold standard, a linear regression model was used to develop a model to estimate NM’s diabetes prevalence from HbA1cs. The American Diabetes Association guidelines HbA1c ranges were used to divide the population into groups according to their last HbA1c result, and patients were tracked by their TriCore identification number over the selected time period.

Results
The derived NM diabetes rate of 10.63%, 95% CI [10.1%–11.1%] was compared to the derived 10.4%, 95% CI [9.8%–11%] by the CDC. Moreover, TriCore’s longitudinal data were able to track a large number of patients’ transition between the different HbA1cs cut offs from 2014 to 2019.

Conclusion
Findings of this study substantiate the value of the laboratory outside of the traditional fee per service lab result model and support a possible novel role for clinical laboratories to play in population health.
Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: outcomes after aggressive surgeries at a single institution
Authors: Ishii Kenta , Yokoyama Yukihiro , Nishida Yoshihiro , Koike Hiroshi , Yamada Suguru , Kodera Yasuhiro , Sassa Naoto , Gotoh Momokazu , Nagino Masato 
Published: June 2020

Abstract

Objective
This study sought to investigate the characteristics of primary and repeated recurrent retroperitoneal liposarcoma.

Methods
Patients treated with primary or recurrent retroperitoneal liposarcoma between 2005 and 2018 were retrospectively reviewed. Survival time analysis of recurrence-free survival and overall survival was conducted using Kaplan–Meier analysis and log-rank test.

Results
Fifty-two patients with primary retroperitoneal liposarcoma were analysed. Amongst them, 46 patients (88%) had undergone surgery. Histologic grades included well-differentiated (n = 21), dedifferentiated (n = 21), myxoid (n = 3) and pleomorphic (n = 1) subtypes. The patients undergoing R0 resection in the first surgery had significantly higher recurrence-free survival rates compared with the patients undergoing non-R0 resection (3-year recurrence-free survival: 80 versus 38%; 5-year recurrence-free survival: 49 versus 29%, P = 0.033). Although overall survival rates tended to be higher in the patients undergoing R0 resection compared with the non-R0 resection, it did not reach to a statistical significant difference (5-year overall survival: 93 versus 75%; 10-year overall survival: 93 versus 59%, P = 0.124). The recurrence rates were 65, 67, 73 and 100%, and the median recurrence-free survival times were 46, 20, 9 and 3 months after the first, second, third and fourth surgeries, respectively. The 5-year overall survival rates were 82, 69, 40 and 0% after the first, second, third and fourth surgeries, respectively.

Conclusions
With repeated recurrence and surgeries, the time to recurrence decreased and the recurrence rate increased. R0 resection in the first surgery was considered the most important for longer recurrence-free survival and radical cure.
hTERT promoter methylation promotes small cell lung cancer progression and radiotherapy resistance
Authors: Zhai Guangsheng , Li Jianbin , Zheng Jianbo , An Peng , Chen Xiaohui , Wang Xiaodong , Li Chuanzhao 
Published: June 2020

Abstract
Small cell lung cancer (SCLC) has been a devastating actuality in clinic and the molecular mechanisms underlying this disease remain unclear. The epigenetic alterations located in the promoter region of human telomerase reverse transcriptase (hTERT) have been demonstrated as one of the most prevalent non-coding genomic modifications in multiple cancers. However, alteration of hTERT promoter methylation in SCLC and the subsequently induced change in tumor cell behavior remains unclear. In this research, we hypothesized that abnormal methylation of hTERT promotor enhanced the progression of SCLC and the outcome of radiotherapy resistance. Quantitative real-time PCR and western blot assays were performed to evaluate the RNA and protein levels of hTERT and enhancer of zeste homolog 2 (EZH2), respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to estimate the viability and X-ray sensitivity of H20 and H446 cell lines. Functionally, upregulation of hTERT promoted the proliferation and migration of H20 and H446 cells, and the high-level of methylation in the promoter region of hTERT induced by radiation caused radio-resistance in SCLC. Mechanically, methylation of hTERT promoter enhanced the progression and radio-resistance of SCLC through upregulating the expression of its downstream effector EZH2.
Hierarchical Bayesian CMB component separation with the No-U-Turn Sampler
Authors: Grumitt R D P , Jew Luke R P , Dickinson C 
Published: June 2020

ABSTRACT
In this paper, we present a novel implementation of Bayesian cosmic microwave background (CMB) component separation. We sample from the full posterior distribution using the No-U-Turn Sampler (NUTS), a gradient-based sampling algorithm. Alongside this, we introduce new foreground modelling approaches. We use the mean shift algorithm to define regions on the sky, clustering according to naively estimated foreground spectral parameters. Over these regions we adopt a complete pooling model, where we assume constant spectral parameters, and a hierarchical model, where we model individual pixel spectral parameters as being drawn from underlying hyperdistributions. We validate the algorithm against simulations of the LiteBIRD and C-Band All-Sky Survey (C-BASS) experiments, with an input tensor-to-scalar ratio of r = 5 × 10−3. Considering multipoles 30 ≤ ℓ &lt; 180, we are able to recover estimates for r. With LiteBIRD-only observations, and using the complete pooling model, we recover r = (12.9 ± 1.4) × 10−3. For C-BASS and LiteBIRD observations we find r = (9.0 ± 1.1) × 10−3 using the complete pooling model, and r = (5.2 ± 1.0) × 10−3 using the hierarchical model. Unlike the complete pooling model, the hierarchical model captures pixel-scale spatial variations in the foreground spectral parameters, and therefore produces cosmological parameter estimates with reduced bias, without inflating their uncertainties. Measured by the rate of effective sample generation, NUTS offers performance improvements of ∼103 over using Metropolis–Hastings to fit the complete pooling model. The efficiency of NUTS allows us to fit the more sophisticated hierarchical foreground model that would likely be intractable with non-gradient-based sampling algorithms.
Altered Patterns of Compositional and Functional Disruption of the Gut Microbiota in Typhoid Fever and Nontyphoidal Febrile Illness
Authors: Haak Bastiaan W , de Jong Hanna K , Kostidis Sarantos , Giera Martin , Maude Rapeephan R , Samad Rasheda , Wijedoru Lalith , Ghose Aniruddha , Faiz Mohammed Abul , Parry Christopher M , Wiersinga W Joost 
Published: June 2020

Abstract

Background
Experimental murine models and human challenge studies of Salmonella Typhi infection have suggested that the gut microbiome plays an important protective role against the development of typhoid fever. Anaerobic bacterial communities have been hypothesized to mediate colonization resistance against Salmonella species by producing short-chain fatty acids, yet the composition and function of the intestinal microbiota in human patients with typhoid fever remain ill defined.

Methods
We prospectively collected fecal samples from 60 febrile patients admitted to Chittagong Medical College Hospital, Bangladesh, with typhoid fever or nontyphoidal febrile illness and from 36 healthy age-matched controls. The collected fecal samples were subjected to 16s rRNA sequencing followed by targeted metabolomics analysis.

Results
Patients with typhoid fever displayed compositional and functional disruption of the gut microbiota compared with patients with nontyphoidal febrile illness and healthy controls. Specifically, typhoid fever patients had lower microbiota richness and alpha diversity and a higher prevalence of potentially pathogenic bacterial taxa. In addition, a lower abundance of short-chain fatty acid–producing taxa was seen in typhoid fever patients. The differences between typhoid fever and nontyphoidal febrile illness could not be explained by a loss of colonization resistance after antibiotic treatment, as antibiotic exposure in both groups was similar.

Conclusions
his first report on the composition and function of the gut microbiota in patients with typhoid fever suggests that the restoration of these intestinal commensal microorganisms could be targeted using adjunctive, preventive, or therapeutic strategies.