bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reengineer healthcare: a human factors and ergonomics framework to improve the socio-technical system
Authors: Santos Raquel 
Published: August 2020

Abstract

Objective
Human Factors and Ergonomics (HFE) discipline is critical to improve the healthcare system. The technical development of medicine in general is not accompanied by the organizational system that supports the delivery of high-quality, safe care. The potential for improvement in care delivery is overwhelming. This paper describes an HFE framework that consists of four main domains of action within the organization: (1) Process; (2) Product; (3) Training and (4) Research. It aims to demonstrate to healthcare stakeholders, especially boards, management and professionals, as well as to the community of human factors, how HFE can be structured to respond to the challenges of improving the socio-technical health system.

Design
None.

Setting
Intra-hospital environment of a private healthcare group.

Participants
None.

Intervention(s)
None.

Main outcome measure(s)
None.

Results
HFE framework.

Conclusion
Together with other disciplines, HFE can and must play a determinant role in the reengineering of a human-centered healthcare. HFE must be embedded in healthcare organizations and must demonstrate its value in a more comprehensive way, so that stakeholders become aware of the benefits and feel the need to ask for help. Examples of systemic, practical and comprehensive applications are needed. This framework is a contribution in this direction.
In vitro activity of olorofim against clinical isolates of Scedosporium species and Lomentospora prolificans using EUCAST and CLSI methodologies
Authors: Rivero-Menendez Olga , Cuenca-Estrella Manuel , Alastruey-Izquierdo Ana 
Published: August 2020

Abstract

Objectives
To evaluate the in vitro activity of olorofim, a new broad-spectrum antifungal with a novel mechanism of action, against a collection of 123 Spanish clinical isolates belonging to five Scedosporium species and Lomentospora prolificans.

Methods
The activity of olorofim against Scedosporium apiospermum (n = 30), Scedosporium boydii (n = 30), Scedosporium ellipsoideum (n = 10), Scedosporium aurantiacum (n = 20), Scedosporium dehoogii (n = 3) and Lomentospora prolificans (n = 30) was compared with that of amphotericin B, voriconazole, isavuconazole and micafungin by performing EUCAST and CLSI reference methods for antifungal susceptibility testing.

Results
Amphotericin B and isavuconazole showed MICs ≥2 mg/L for all the species evaluated and voriconazole was moderately active (GM, MIC50 and MIC90 values ≤2 mg/L) against all of them except L. prolificans. Micafungin was effective against S. apiospermum complex strains, but exhibited elevated MECs for S. dehoogii and S. aurantiacum. Olorofim showed low MICs for all the Scedosporium strains tested (GM values were lower than 0.130 and 0.339 by the EUCAST method and the CLSI method, respectively, for all of the species), including those belonging to the MDR species L. prolificans, for which GM values were 0.115 and 0.225 mg/L by the EUCAST method and the CLSI method, respectively, while the GMs for the rest of the antifungals evaluated were higher than 3.732 mg/L using both methodologies.

Conclusions
Olorofim displayed promising in vitro activity against the Scedosporium and L. prolificans strains tested, some of which have reduced susceptibility to the antifungals that are currently in use.
Evaluation and Comparison of Bioactive Constituents of Artemisiae argyi Folium Collected at Different Developmental Stages
Authors: Zhang Dan , Yao Limin , Chang Yaqing , Yang Guiya , Xue Zijing , Wang Lei , Zheng Yuguang , Guo Long 
Published: August 2020

AbstractBackgroundArtemisiae argyi Folium (AF) has been used as herbal medicine and a food supplement in China and other Asian countries. There is no report about whether the different developmental stages can influence the bioactive compositions of AF.ObjectiveTo investigate the dynamic changes of bioactive constituents of AF collected at different developmental stages.MethodThe volatile and nonvolatile bioactive components in AF collected at six different developmental stages were analyzed by gas chromatography-mass spectrometry and (GC-MS) high-performance liquid chromatography (HPLC). Chemometrics analysis, including principal component analysis (PCA) and partial least squares discrimination analysis (PLS-DA), were further performed to compare and discriminate the AF samples based on the analysis results.ResultsThe results indicated the bioactive compositions in AF underwent obvious changes during the period of growth. The volatile compositions of AF collected at different stages were the same, while their relative contents were different. Six volatile compounds could be regarded as chemical markers, which were responsible for the intergroup differences. The phenolic profiles of AF at different stages indicated a similar composition when the content levels of the main phenolic compounds were variated.ConclusionsThe comparative results will facilitate better understanding of dynamic changes of bioactive constituents of AF samples collected at different stages and will provide useful information for cultivation and utilization of this herbal medicine.HighlightsThe volatile and nonvolatile bioactive components in AF collected at different developmental stages were evaluated and compared for the first time.
Identification of A-Type Proanthocyanidins in Cranberry-Based Foods and Dietary Supplements by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, First Action Method: 2019.05
Authors: Esquivel-Alvarado Daniel , Alfaro-Viquez Emilia , Krueger Christian G , Vestling Martha M , Reed Jess D 
Published: August 2020

Abstract

Background
Cranberry proanthocyanidins (c-PAC) are oligomeric structures of flavan-3-ol units, which possess A-type interflavan bonds. c-PAC differs from other botanical sources because other PAC mostly have B-type interflavan bonds. Cranberry products used to alleviate and prevent urinary tract infections may suffer from adulteration, where c-PAC are replaced with less expensive botanical sources of PAC that contain B-type interflavan bonds.

Objective
Identifying the presence of A-type interflavan bonds in cranberry fruit and dietary supplements.

Methods
Thirty-five samples reported to contain A-type PAC (cranberry fruit and cranberry products) and 36 samples reported to contain B-type PAC (other botanical sources) were identified and differentiated using MALDI-TOF MS, deconvolution of overlapping isotope patterns, and principal component analysis (PCA).

Results
Our results show that both MALDI-TOF MS and deconvolution of overlapping isotope patterns were able to identify the presence of A-type interflavan bonds with a probability greater than 90% and a confidence of 95%. Deconvolution of MALDI-TOF MS spectra also determined the ratio of A-type to B-type interflavan bonds at each degree of polymerization in cranberry fruit and cranberry products, which is a distinguishing feature of c-PAC in comparison to other botanical sources of PAC. PCA shows clear differences based on the nature of the interflavan bonds.

Conclusions
MALDI-TOF MS, deconvolution of overlapping isotope patterns of MALDI-TOF MS spectra, and PCA allow the identification, estimation, and differentiation of A-type interflavan bonds in cranberry-based foods and dietary supplements among other botanical sources containing mostly B-type interflavan bonds.
A New Green In Situ Effervescent CO2-Table-Induced Switchable Hydrophilicity Solvent Extraction Method of Rhodamine B in Food and Soft Drink Samples
Authors: Khan Naeemullah , Tuzen Mustafa 
Published: August 2020

Abstract

Background
A new and simple effervescent CO2-table-induced switchable hydrophilicity solvent extraction method (CI-SHS) was used for the preconcentration of rhodamine B (RB).

Objective
The main theme of the proposed method to disperse green solvent by in situ CO2-table system overcome on the contamination and to avoid the dispersion by using different chemicals.

Methods
Switchable hydrophilicity solvent (N, N-Dimethyl cyclohexylamine) was dispersed in an aqueous solution by reaction of CO2-table of sodium carbonate and citric acid to enhance the contact area between two medium, which radically improved the extraction capacity of the RB from aqueous medium to switchable solvent. The phase separation was achieved by simple heating not by centrifugation that makes a change on hydrophilicity to hydrophobicity. The supernatant-enriched RB- N, N-Dimethyl cyclohexylamine phase was withdrawn and injected into the UV glass cells. The absorbance was measured at 542.

Results
Limit of detection and enhancement factor were achieved to be 0.042 and 50 µg/L. Validity and accuracy of the method verified by analysis of real samples by the spiking addition method. The relative standard deviation was obtained at 3.2%. The method was applied to food and soft drink samples.

Conclusions
This method offers high sensitivity, selectivity, accuracy, and precision for the separation, preconcentration, and spectrophotometric determination of RB. Simple, fast, low-cost, and green extraction method was developed.

Highlights
High enrichment factor and lower detection limits were observed in this microextraction method. Present method is sensitive, selective, very accurate, and precise.
Comparison of Spectroscopic Techniques Combined with Chemometrics for Cocaine Powder Analysis
Authors: Eliaerts Joy , Meert Natalie , Dardenne Pierre , Baeten Vincent , Pierna Juan-Antonio Fernandez , Van Durme Filip , De Wael Karolien , Samyn Nele 
Published: August 2020

Abstract
Spectroscopic techniques combined with chemometrics are a promising tool for analysis of seized drug powders. In this study, the performance of three spectroscopic techniques [Mid-InfraRed (MIR), Raman and Near-InfraRed (NIR)] was compared. In total, 364 seized powders were analyzed and consisted of 276 cocaine powders (with concentrations ranging from 4 to 99 w%) and 88 powders without cocaine. A classification model (using Support Vector Machines [SVM] discriminant analysis) and a quantification model (using SVM regression) were constructed with each spectral dataset in order to discriminate cocaine powders from other powders and quantify cocaine in powders classified as cocaine positive. The performances of the models were compared with gas chromatography coupled with mass spectrometry (GC–MS) and gas chromatography with flame-ionization detection (GC–FID). Different evaluation criteria were used: number of false negatives (FNs), number of false positives (FPs), accuracy, root mean square error of cross-validation (RMSECV) and determination coefficients (R2). Ten colored powders were excluded from the classification data set due to fluorescence background observed in Raman spectra. For the classification, the best accuracy (99.7%) was obtained with MIR spectra. With Raman and NIR spectra, the accuracy was 99.5% and 98.9%, respectively. For the quantification, the best results were obtained with NIR spectra. The cocaine content was determined with a RMSECV of 3.79% and a R2 of 0.97. The performance of MIR and Raman to predict cocaine concentrations was lower than NIR, with RMSECV of 6.76% and 6.79%, respectively and both with a R2 of 0.90. The three spectroscopic techniques can be applied for both classification and quantification of cocaine, but some differences in performance were detected. The best classification was obtained with MIR spectra. For quantification, however, the RMSECV of MIR and Raman was twice as high in comparison with NIR. Spectroscopic techniques combined with chemometrics can reduce the workload for confirmation analysis (e.g., chromatography based) and therefore save time and resources.
Structural insight and stability of TNFR-Fc fusion protein (Etanercept) produced by using transgenic silkworms
Authors: Kiyoshi Masato , Tatematsu Ken-Ichiro , Tada Minoru , Sezutsu Hideki , Shibata Hiroko , Ishii-Watabe Akiko 
Published: August 2020

Abstract
Therapeutic proteins expressed using transgenic animals have been of great interest for several years. Especially, transgenic silkworm has been studied intensively because of its ease in handling, low-cost, high-yield and unique glycosylation patterns. However, the physicochemical property of the therapeutic protein expressed in transgenic silkworm remains elusive. Here, we constructed an expression system for the TNFR-Fc fusion protein (Etanercept) using transgenic silkworm. The TNFR-Fc fusion protein was employed to N-glycan analysis, which revealed an increased amount of afucosylated protein. Evidence from surface plasmon resonance analysis showed that the TNFR-Fc fusion protein exhibit increased binding affinity for Fcγ receptor IIIa and FcRn compared to the commercial Etanercept, emphasizing the profit of expression system using transgenic silkworm. We have further discussed the comparison of higher order structure, thermal stability and aggregation of the TNFR-Fc fusion protein.
The Unstable Object: Glifo, Blow and Sacco at MoMA, 1972
Authors: Halland Ingrid 
Published: August 2020

Summary
This article discusses three radical objects—the Glifo shelf from 1966, the Blow chair from 1967 and the Sacco chair from 1968—that were all exhibited at Museum of Modern Art’s ground-breaking architecture and design exhibition Italy: The New Domestic Landscape in 1972. The article proposes that these early postmodern objects should not merely be considered a new stylistic development, a new aesthetics or as expressing new conceptions of sociopolitical ideologies; rather, they can be considered as instigating a new epistemological status of objects. A close reading reveals how the structural element of Glifo, Blow and Sacco is hard to trace and how these objects’ physical limits seem to soften or even dissolve. By engaging with the writings of Jean Baudrillard, Jacques Derrida and Manfredo Tafuri, this article claims that the poststructuralist landscape of ideas has a material counterpart in some objects from the late 1960s and then discusses the political and intellectual implications of such unstable objects.
Evaluating National Preventive Mechanisms: A Conceptual Model
Authors: Carver Richard , Handley Lisa 
Published: August 2020

Abstract
This article outlines a rigorous and systematic approach to evaluating both the performance and impact of national preventive mechanisms (NPMs) formed under the Optional Protocol to the Convention against Torture. Many human rights practitioners remain sceptical about both the desirability and feasibility of evaluating human rights work. One obstacle has been that ‘indicators’ of human rights progress are formulated without evidence that they actually have a causal relationship to the intended outcome. By contrast, the tools used in this assessment model are derived from scientific research into what forms of torture prevention actually work, meaning that greater weight can be assigned to more effective activities (and vice versa). The model is piloted in an assessment of the performance and impact of the Georgian NPM, which in ten years of work is shown to have had a significant impact in reducing the incidence of torture and other ill-treatment, particularly in police detention and prisons.
Women at the Frontline of COVID-19: Can Gender Mainstreaming in Free Trade Agreements Help?
Authors: Bahri* Amrita 
Published: August 2020

ABSTRACT
Health pandemics affect women and men differently, and they can make the existing gender inequalities much worse. COVID-19 is one such pandemic, which can have substantial gendered implications both during and in the post-pandemic world. Its economic and social consequences could deepen the existing gender inequalities and roll back the limited gains made in respect of women empowerment in the past few decades. The impending global recession, multiple trade restrictions, economic lockdown, and social distancing measures can expose vulnerabilities in social, political, and economic systems, which, in turn, could have a profound impact on women’s participation in trade and commerce. The article outlines five main reasons that explain why this health pandemic has put women employees, entrepreneurs, and consumers at the frontline of the struggle. It then explores how free trade agreements can contribute in repairing the harm in the post-pandemic world. In doing so, the author sheds light on various ways in which the existing trade agreements embrace gender equality considerations and how they can be better prepared to help minimize the pandemic-inflicted economic loss to women.
Insulin insulated: barriers to competition and affordability in the United States insulin market
Authors: Knox Ryan 
Published: August 2020

Abstract
Insulin prices in the United States are skyrocketing. In addition to several challenges common to high-priced prescription drugs, insulin faces several unique legal, regulatory, and practical challenges to increasing access and affordability. Despite the fact that insulin was developed almost 100 years ago, the insulin market is dominated by only three companies and there continue to be no biosimilar competitors in the United States. Unlike many high-priced prescription drugs, insulin has been insulated from competition for years. This article examines the barriers to competition in the insulin market, considering the challenges surrounding regulatory approval, interchangeability, trade secrets, and anticompetitive behavior. Further, this article discusses the potential and limitations of various legislative proposals to address access to insulin. In doing so, this article attempts to explain why there is such limited competition in the insulin market and identifies issues specific to the insulin market for lawmakers to consider in developing proposals to address access to affordable insulin in the United States.
Increasing the Role of Phenomenology in Psychiatric Diagnosis–The Clinical Staging Approach
Authors: Drożdżowicz Anna 
Published: August 2020

Abstract
Recent editions of diagnostic manuals in psychiatry have focused on providing quick and efficient operationalized criteria. Notwithstanding the genuine value of these classifications, many psychiatrists have argued that the operationalization approach does not sufficiently accommodate the rich and complex domain of patients’ experiences that is crucial for clinical reasoning in psychiatry. How can we increase the role of phenomenology in the process of diagnostic reasoning in psychiatry? I argue that this could be done by adopting a clinical staging approach in diagnostic reasoning in psychiatry. The approach has the resources to include the progressive nature of patients’ experiences to a much greater degree than is currently practiced. It can address the recent plea for increasing the role of phenomenology in psychiatric diagnosis by offering a model for clinical reasoning that goes beyond the operationalized, static criteria of diagnostic manuals, without depriving us of their benefits.
Questionable Agreement: The Experience of Depression and DSM-5 Major Depressive Disorder Criteria
Authors: Nussbaum Abraham M 
Published: August 2020

AbstractImmediately before the release of DSM-5, a group of psychiatric thought leaders published the results of field tests of DSM-5 diagnostic criteria. They characterized the interrater reliability for diagnosing major depressive disorder by two trained mental health practitioners as of “questionable agreement.” These field tests confirmed an open secret among psychiatrists that our current diagnostic criteria for diagnosing major depressive disorder are unreliable and neglect essential experiences of persons in depressive episodes. Alternative diagnostic criteria exist, but psychiatrists rarely encounter them, forestalling the discipline’s epistemological crisis. In Alsadair MacIntyre’s classic essay, such crises occur in science when a person encounters a rival schemata that is incompatible with their current schemata and subsequently constructs a narrative that allows them to reconstruct their own tradition. In search of rival schemata that are in conversation with their own tradition, psychiatric practitioners can utilize alternative diagnostic criteria like the Cultural Formulation Interview, embrace an epistemologically humble psychiatry, and attend to the narrative experience of a person experiencing a depressive episode.
Comparing the Cost-Effectiveness of Innovative Colorectal Cancer Screening Tests
Authors: Peterse Elisabeth F P , Meester Reinier G S , de Jonge Lucie , Omidvari Amir-Houshang , Alarid-Escudero Fernando , Knudsen Amy B , Zauber Ann G , Lansdorp-Vogelaar Iris 
Published: August 2020

Abstract

Background
Colorectal cancer (CRC) screening with colonoscopy and the fecal immunochemical test (FIT) is underused. Innovative tests could increase screening acceptance. This study determined which of the available alternatives is most promising from a cost-effectiveness perspective.

Methods
The previously validated Microsimulation Screening Analysis-Colon model was used to evaluate the cost-effectiveness of screening with capsule endoscopy every 5 or 10 years, computed tomographic colonography every 5 years, the multi-target stool DNA test every 1 or 3 years, and the methylated SEPT9 DNA plasma assay (mSEPT9) every 1 or 2 years. We also compared these strategies with annual FIT screening and colonoscopy screening every 10 years. Quality-adjusted life-years gained (QALYG), number of colonoscopies, and incremental cost-effectiveness ratios were projected. We assumed a willingness-to-pay threshold of $100 000 per QALYG.

Results
Among the alternative tests, computed tomographic colonography every 5 years, annual mSEPT9, and annual multi-target stool DNA screening had incremental cost-effectiveness ratios of $1092, $63 253, and $214 974 per QALYG, respectively. Other screening strategies were more costly and less effective than (a combination of) these 3. Under the assumption of perfect adherence, annual mSEPT9 screening resulted in more QALYG, CRC cases averted, and CRC deaths averted than annual FIT screening but led to a high rate of colonoscopy referral (51% after 3 years, 69% after 5 years). The alternative tests were not cost-effective compared with FIT and colonoscopy.

Conclusions
This study suggests that for individuals not willing to participate in FIT or colonoscopy screening, mSEPT9 is the test of choice if the high colonoscopy referral rate is acceptable to them.
Audience Heterogeneity, Costly Signaling, and Threat Prioritization: Bureaucratic Reputation-Building in the EU
Authors: van der Veer Reinout Arthur 
Published: August 2020

Abstract
Organizational reputation theory suggests reputational threats can induce public organizations to change their behavior. However, it offers few insights into how organizations in contexts of high audience heterogeneity prioritize between conflicting threats, or how they ensure reputation-seeking signals reach their intended audiences. This article seeks to close these knowledge gaps. It expects organizational threat prioritization to be shaped by the centrality of the threat to the organization’s distinct reputation, and by differences in audiences’ capacity to put pressure on the organization through mobilization. Moreover, it argues that public organizations strategically vary the observability and costliness of outgoing reputation-seeking signals in response to shifts in the balance of reputational threats they face. It finds support for these expectations in the context of the European Commission, a supranational organization operating in a context of high audience heterogeneity and severe reputational threats. The empirical analysis is based on the Bayesian longitudinal modeling and simulation of Commission decision-making and applies a novel dataset on fiscal rule enforcement in the European Union (EU). The findings have important implications for organizational reputation theory and call for a renewed focus on the mechanisms underlying audience-induced organizational behavior.