bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updates to the Regional Seismic Travel Time (RSTT) Model: 1. Tomography
Authors: Begnaud Michael L. , Myers Stephen C. , Young Brian , Hipp James R. , Dodge Doug , Phillips W. Scott 
Published: November 2020

AbstractA function of global monitoring of nuclear explosions is the development of Earth models for predicting seismic travel times for more accurate calculation of event locations. Most monitoring agencies rely on fast, distance-dependent one-dimensional (1D) Earth models to calculate seismic event locations quickly and in near real-time. RSTT (Regional Seismic Travel Time) is a seismic velocity model and computer software package that captures the major effects of three-dimensional crust and upper mantle structure on regional seismic travel times, while still allowing for fast prediction speed (milliseconds). We describe updates to the RSTT model using a refined data set of regional phases (i.e., Pn, Pg, Sn, Lg) using theBayeslocrelative relocation algorithm. The tomographic inversion shown here acts to refine the previous RSTT public model (rstt201404um) and displays significant features related to areas of global tectonic complexity as well as further reduction in arrival residual values. Validation of the updated RSTT model demonstrates significant reduction in median epicenter mislocation (15.3 km) using all regional phases compared to theiasp911D model (22.1 km) as well as to the current station correction approach used at the Comprehensive Nuclear-Test-Ban Treaty Organization International Data Centre (18.9 km).
Impact of melamine and its derivatives on the properties of poly(vinyl acetate)-based composite wood adhesive
Authors: Góral Zuzanna , Mastalska-Popławska Joanna , Izak Piotr , Rutkowski Paweł , Gnyla Joanna , Majka Tomasz M. , Pielichowski Krzysztof 
Published: November 2020

AbstractA fire retardant composite adhesive for bonding wood and wood-based elements has been developed and characterized. To obtain the enhanced fire-proof properties of the wood adhesive dispersion based on the poly(vinyl acetate) (PVAc), ceramic fillers (17.5 wt% total)—alumina, silica, kaolin and glass fibers were applied. Moreover, fire retardants such as melamine, melamine phosphate and melamine polyphosphate (up to 7 wt%) were also used. Thermal analysis (TG-DSC), strength tests, rheology, pH and flammability measurements (PCFC) were performed. The best properties of the adhesive were achieved for ceramic additives supported by melamine phosphate. A slight improvement of shear strength, shift of the last decomposition step of PVAc (residue degradation) towards higher temperatures by about 50 °C, reduction in mass loss from 100 wt% to less than 70 wt% and about 30–40% improvement of flammability parameters such as heat release capacity, total heat release or peak heat release rate were found compared to the pure poly(vinyl acetate) adhesive.
Laminar air flow reduces particle load in TKA—even outside the LAF panel: a prospective, randomized cohort study
Authors: Kirschbaum Stephanie , Hommel Hagen , Strache Peggy , Horn Roland , Falk Roman , Perka Carsten 
Published: November 2020

Abstract
Purpose
Released particles are a major risk of airborne contamination during surgery. The present prospective study investigated the quantitative and qualitative particle load in the operating room (OR) depending on location, time of surgery and use of laminar air flow (LAF) system.

Methods
The particle load/m3 was measured during the implantation of 12 total knee arthroplasties (6 × LAF, 6 × Non-LAF) by using the Met One HHPC 6 + device (Beckmann Coulter GmbH, Germany). Measurement was based on the absorption and scattering of (laser) light by particles and was performed at three different time-points [empty OR, setting up, ongoing operation) at 3 fixed measurement points [OR table (central LAF area), anaesthesia tower (marginal LAF area), surgical image amplifier (outside LAF area)].

Results
Independent of time and location, all measurements showed a significantly higher particle load in the Non-LAF group (p < 0.01). With ongoing surgical procedure both groups showed increasing particle load. While there was a major increase of fine particles (size < 1 µm) with advancing activity in the LAF group, the Non-LAF group showed higher particle gain with increasing particle size. The lowest particle load in the LAF group was measured at the operating column, increasing with greater distance from the operating table. The Non-LAF group presented a significantly higher particle load than the LAF group at all locations.

Conclusion
The use of a LAF system significantly reduces the particle load and therefore potential bacterial contamination regardless of the time or place of measurement and therefore seems to be a useful tool for infection prevention. As LAF leads to a significant decrease of respirable particles, it appears to be a protective factor for the health of the surgical team regardless of its use in infection prevention.

Level of evidence
I.
On the synergy of matrix-isolation infrared spectroscopy and vibrational configuration interaction computations
Authors: Dinu Dennis F. , Podewitz Maren , Grothe Hinrich , Loerting Thomas , Liedl Klaus R. 
Published: November 2020

AbstractThe key feature of matrix-isolation infrared (MI-IR) spectroscopy is the isolation of single guest molecules in a host system at cryogenic conditions. The matrix mostly hinders rotation of the guest molecule, providing access to pure vibrational features. Vibrational self-consistent field (VSCF) and configuration interaction computations (VCI) on ab initio multimode potential energy surfaces (PES) give rise to anharmonic vibrational spectra. In a single-sourced combination of these experimental and computational approaches, we have established an iterative spectroscopic characterization procedure. The present article reviews the scope of this procedure by highlighting the strengths and limitations based on the examples of water, carbon dioxide, methane, methanol, and fluoroethane. An assessment of setups for the construction of the multimode PES on the example of methanol demonstrates that CCSD(T)-F12 level of theory is preferable to compute (a) accurate vibrational frequencies and (b) equilibrium or vibrationally averaged structural parameters. Our procedure has allowed us to uniquely assign unknown or disputed bands and enabled us to clarify problematic spectral regions that are crowded with combination bands and overtones. Besides spectroscopic assignment, the excellent agreement between theory and experiment paves the way to tackle questions of rather fundamental nature as to whether or not matrix effects are systematic, and it shows the limits of conventional notations used by spectroscopists.
Insight into the effects of moisture and layer build-up on the formation of lead soaps using micro-ATR-FTIR spectroscopic imaging of complex painted stratigraphies
Authors: Possenti Elena , Colombo Chiara , Realini Marco , Song Cai Li , Kazarian Sergei G. 
Published: November 2020

AbstractMetal soaps are formed in paint layers thorough the reaction of metal ions of pigments and fatty acids of organic binders. In this study, micro-ATR-FTIR spectroscopic imaging was used to analyse the formation of lead soaps in oil-based paint layers in relation to their exposure to moisture sources. The investigations were carried out on authentic samples of complex stratigraphies from cold painted terracotta statues (Sacred Mount, Varallo, UNESCO) and different IR-active lead white pigments, organic materials, and lead soaps were discriminated. The saponification of selected paint layers was correlated to the conservation history, the manufacturing technique, and the build-up of layers. The presence of hydrophilic layers within the stratigraphy and their role as a further water source are discussed. Furthermore, the modifications experienced by lead-based pigments from the core of an intact grain of pigment towards the newly formed decay phases were investigated via a novel approach based on shift of the peak for the corresponding spectral bands and their integrated absorbance in the ATR-FTIR spectra. Qualitative information on the spatial distribution from the chemical images was combined with quantitative information on the peak shift to evaluate the different manufacture (lead carbonate, basic lead carbonate) or the extent of decay undergone by the lead-based pigments as a function of their grain size, contiguous layers, and moisture source. Similar results, having a high impact on heritage science and analytical chemistry, allow developing up-to-date conservation strategies by connecting an advanced knowledge of the materials to the social and conservation history of artefacts.
Lone Atrial Flutter in Children and Adolescents: Is It Really “Lone”?
Authors: Dieks Jana-K. , Backhoff David , Schneider Heike E. , Müller Matthias J. , Krause Ulrich , Paul Thomas 
Published: November 2020

AbstractAtrial flutter (AFL) in children and adolescents beyond the neonatal period in the absence of any underlying myocardial disease (“lone AFL”) is rare and data is limited. Our study aims to present clinical and electrophysiological data of presumed “lone AFL” in pediatric patients and discuss the role of endomyocardial biopsy (EMB) and further follow-up. Since July 2005, eight consecutive patients at a median age of 12.7 (range 10.4–16.7) years presenting with presumed “lone AFL” after negative non-invasive diagnostic work-up had electrophysiological study (EPS) and induction of cavotricuspid isthmus (CTI) conduction block by radiofrequency (RF) current application. In 6/8 patients EMB could be taken. Induction of CTI conduction block was achieved in all patients. Histopathological examination of EMB from the right ventricular septum exhibited myocarditis or cardiomyopathy in 4/6 patients, respectively. During follow-up, 4/8 patients had recurrent arrhythmia (AFL n = 2, wide QRS complex tachycardia n = 1, monomorphic premature ventricular contractions n = 1) after the ablation procedure. 3/4 patients with recurrent arrhythmia had pathological EMB results. The remaining patient with recurrent arrhythmia had a negative EMB but was diagnosed with Brugada syndrome during further follow-up. Taking together results of EMB and further clinical course, only 3/8 patients finally turned out to have true “lone AFL”. Our study demonstrates that true “lone AFL” in children and adolescents is rare. EMB and clinical course revealed an underlying cardiac pathology in the majority of the individuals studied. EMB was very helpful in order to timely establish the diagnosis of myocarditis or cardiomyopathy.
High-temperature creep of magnetite and ilmenite single crystals
Authors: Till J. L. , Rybacki E. 
Published: November 2020

AbstractWe performed deformation experiments on dry natural single crystals of magnetite and ilmenite to determine the rheological behavior of these oxide minerals as a function of temperature, orientation, and oxygen fugacity. Samples were deformed at temperatures of 825–1150 $$\,^{\circ }$$

∘

C to axial strains of up to 15–24% under approximately constant stress conditions up to 120 MPa in a dead-load-type creep rig at ambient pressure in a controlled gas atmosphere. Oxygen fugacity ranged from 10$$^{-9.4}$$

-
9.4

to 10$$^{-4}$$

-
4

atm. Ilmenite creep was insensitive to oxygen fugacity, while magnetite displayed a strong, non-monotonic oxygen fugacity dependence, with creep rates varying as $$f_{O_{2}}^{-0.7}$$

f

O
2

-
0.7

and $$f_{O_{2}}^{0.4}$$

f

O
2

0.4

at more reducing and more oxidizing conditions, respectively. Dislocation creep rates of magnetite single crystals were weakly dependent on crystallographic orientation with stress exponents that varied between 2.8 and 4.3 (mean 3.5 ± 0.4). Magnetite compressed parallel to <100>, <110>, and <111> axes exhibited apparent activation energies of 315±5, 345±30, and 290±5 kJ/mol, respectively. We estimated $${f_O}_2$$

f
O

2

-independent magnetite activation energies of 715 ± 150, 725 ± 145, and 690 ± 150 kJ/mol for <100>, <110>, and <111> orientations, respectively, in the region of negative $${f_O}_2$$

f
O

2

-dependence. Ilmenite single crystals were compressed parallel, normal, and inclined to the c-axis. Stress exponents of 3.4, 4.3, and 3.9 indicate dislocation creep with activation energies of 420 ± 35, 345 ± 30, and 360 ± 40 kJ/mol, respectively, for these orientations. Mechanical anisotropy in ilmenite is notably higher than in magnetite, as expected from its lower crystal symmetry. Constitutive equations were formulated for ilmenite and magnetite creep.
Autoimmunological serum parameters and bone mass density in premature ovarian insufficiency: a retrospective cohort study
Authors: Beitl Klara , Rosta Klara , Poetsch Nina , Seifried Manuel , Mayrhofer Daniel , Soliman Barbara , Marculescu Rodrig , Ott Johannes 
Published: November 2020

Abstract
Purpose
It is still not clear whether to screen women with primary premature ovarian insufficiency for autoimmunity. Moreover, a possible association of autoimmunity with decreased bone mass density in premature ovarian insufficiency patients has not been evaluated. Thus, the objectives of this study were to review our experience with the use of an autoimmune screening panel in premature ovarian insufficiency women and to focus on bone mass density.

Methods
In a retrospective cohort study, 76 chromosomally normal women with primary premature ovarian insufficiency were included. The main outcome parameters were the results of an autoimmune screening panel and of dual-energy X-ray absorptiometry.

Results
Median age was 33 years. Sixty percent of premature ovarian insufficiency patients revealed abnormal dual-energy X-ray absorptiometry results (minimal T-score < −1.0). Any signs of autoimmunity were found in 21 women (36.2%). The most frequent abnormal results were increased thyroperoxidase antibodies (24.1%) and thyroglobulin antibodies (20.7%). A longer duration of amenorrhea (β = −0.015; p = 0.007), any abnormality during autoimmune screening (β = −0.940; p = 0.010), and a lower body mass index (β = −0.057; p = 0.036) were associated with a lower minimal T-score.

Conclusion
In chromosomally normal women with primary premature ovarian insufficiency, the prevalence of autoimmunity and decreased bone mass density seem high. Our data highlight the association between autoimmune abnormalities and decreased dual-energy X-ray absorptiometry results.
Phase field simulation of fatigue crack propagation under complex load situations
Authors: Schreiber Christoph , Müller Ralf , Kuhn Charlotte 
Published: November 2020

AbstractWithin this work, we utilize the framework of phase field modeling for fracture in order to handle a very crucial issue in terms of designing technical structures, namely the phenomenon of fatigue crack growth. So far, phase field fracture models were applied to a number of problems in the field of fracture mechanics and were proven to yield reliable results even for complex crack problems. For crack growth due to cyclic fatigue, our basic approach considers an additional energy contribution entering the regularized energy density function accounting for crack driving forces associated with fatigue damage. With other words, the crack surface energy is not solely in competition with the time-dependent elastic strain energy but also with a contribution consisting of accumulated energies, which enables crack extension even for small maximum loads. The load time function applied to a certain structure has an essential effect on its fatigue life. Besides the pure magnitude of a certain load cycle, it is highly decisive at which point of the fatigue life a certain load cycle is applied. Furthermore, the level of the mean load has a significant effect. We show that the model developed within this study is able to predict realistic fatigue crack growth behavior in terms of accurate growth rates and also to account for mean stress effects and different stress ratios. These are important properties that must be treated accurately in order to yield an accurate model for arbitrary load sequences, where various amplitude loading occurs.
Evolution of the stiffness tetrad in fiber-reinforced materials under large plastic strain
Authors: Weber Martin , Glüge Rainer , Altenbach Holm 
Published: November 2020

AbstractThe main aim of this work is to track the evolution of the stiffness tetrad during large plastic strain. Therefore, the framework of a general finite plasticity theory is developed. Some special cases are examined, and the case of a material plasticity theory is considered more closely. Its main feature is that the elasticity law changes during plastic deformations, for which we develop an approach. As sample materials, we use three types of fiber-reinforced composites. For numerical experiments and verification of the model’s predictions, finite element simulations of representative volume elements for uni-, bi- and tri-directional reinforced materials with periodic boundary conditions are used. From these, we extract the stiffness tetrads before and after large deformations of the material. We quantify the change of the stiffness tetrads due to the fiber reorientation. Finally, we propose an analytical evolution with three parameters that account reasonably well for the evolution of the stiffness tetrad.
Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics
Authors: Vastagh Csaba , Farkas Imre , Scott Michael M. , Liposits Zsolt 
Published: November 2020

AbstractGlucagon-like peptide-1 (GLP-1) regulates reproduction centrally, although, the neuroanatomical basis of the process is unknown. Therefore, the putative networking of the central GLP-1 and gonadotropin-releasing hormone (GnRH) systems was addressed in male mice using whole mount immunocytochemistry and optogenetics. Enhanced antibody penetration and optical clearing procedures applied to 500–1000 µm thick basal forebrain slices allowed the simultaneous visualization of the two distinct systems in the basal forebrain. Beaded GLP-1-IR axons innervated about a quarter of GnRH neurons (23.2 ± 1.4%) forming either single or multiple contacts. GnRH dendrites received a more intense GLP-1 innervation (64.6 ± 0.03%) than perikarya (35.4 ± 0.03%). The physiological significance of the innervation was examined by optogenetic activation of channelrhodopsin-2 (ChR2)-expressing axons of preproglucagon (GCG) neurons upon the firing of GnRH neurons by patch clamp electrophysiology in acute brain slices of triple transgenic mice (Gcg-cre/ChR2/GFP-GnRH). High-frequency laser beam stimulation (20 Hz, 10 ms pulse width, 3 mW laser power) of ChR2-expressing GCG axons in the mPOA increased the firing rate of GnRH neurons (by 75 ± 17.3%, p = 0.0007). Application of the GLP-1 receptor antagonist, Exendin-3-(9-39) (1 μM), prior to the photo-stimulation, abolished the facilitatory effect. In contrast, low-frequency trains of laser pulses (0.2 Hz, 60 pulses) had no effect on the spontaneous postsynaptic currents of GnRH neurons. The findings indicate a direct wiring of GLP-1 neurons with GnRH cells which route is excitatory for the GnRH system. The pathway may relay metabolic signals to GnRH neurons and synchronize metabolism with reproduction.
Low-power integrated transmitter design using frequency multiplication techniques
Authors: Stadelmayer Markus , Schumacher Tim , Faseth Thomas , Pretl Harald 
Published: November 2020

AbstractThis paper proposes an approach to employ frequency multiplication techniques like edge-combining and third harmonic extraction in ultra-low-power integrated transmitter design. The overall power demand of the transmitter is reduced by keeping operating frequency of its components low. For that reason, edge-combining and third harmonic extraction are integrated directly into a switched mode power amplifier. Hence, the radio frequency signal is generated just before it is fed to the antenna. This leads to a reduced power demand of the overall transmitter in comparison to conventional designs where the oscillator and other components are operated directly at the radio frequency.Within this paper we propose an amplifier that generates a 2.4 GHz carrier frequency from a ring oscillator running at a low 200 MHz resulting in a frequency multiplication factor of twelve. The exemplary design is targeted to be used in ultra-low-power short range applications. Hence, our simulations using extracted layout models show that the amplifier provides an output power of approximately -12 dBm at a supply voltage of 0.6 V while consuming 2.4 mW of power fully integrated in a 180 nm 1P6M CMOS process.This demonstrates that the proposed techniques are especially suitable for ultra-low-power transmitter in short range applications. That includes medical and body area network applications.
Clinical characteristics of 172 children and adolescents with body dysmorphic disorder
Authors: Rautio Daniel , Jassi Amita , Krebs Georgina , Andrén Per , Monzani Benedetta , Gumpert Martina , Lewis Angela , Peile Lauren , Sevilla-Cermeño Laura , Jansson-Fröjmark Markus , Lundgren Tobias , Hillborg Maria , Silverberg-Morse Maria , Clark Bruce , Fernández de la Cruz Lorena , Mataix-Cols David 
Published: November 2020

AbstractBody dysmorphic disorder (BDD) often starts in childhood, with most cases developing symptoms before age 18. Yet, BDD research has primarily focused on adults. We report the clinical characteristics of the world’s largest cohort of carefully diagnosed youths with BDD and focus on previously unexplored sex and age differences. We systematically collected clinical data from 172 young people with BDD consecutively referred to 2 specialist pediatric obsessive–compulsive and related disorders outpatient clinics in Stockholm, Sweden and in London, England. A series of clinician-, self-, and parent-reported measures were administered. The cohort consisted of 136 girls, 32 boys, and 4 transgender individuals (age range 10–19 years). The mean severity of BDD symptoms was in the moderate to severe range, with more than one third presenting with severe symptoms and more than half showing poor or absent insight/delusional beliefs. We observed high rates of current psychiatric comorbidity (71.5%), past or current self-harm (52.1%), suicide attempts (11.0%), current desire for cosmetic procedures (53.7%), and complete school dropout (32.4%). Compared to boys, girls had significantly more severe self-reported BDD symptoms, depression, suicidal thoughts, and self-harm. Compared to the younger participants (14 or younger), older participants had significantly more severe compulsions and were more likely to report a desire for conducting cosmetic procedures. Adolescent BDD can be a severe and disabling disorder associated with significant risks and substantial functional impairment. The clinical presentation of the disorder is largely similar across sexes and age groups, indicating the importance of early detection and treatment. More research is needed specifically focusing on boys and pre-pubertal individuals with BDD.