bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and impact of cardiac injury on COVID‐19: A systematic review and meta‐analysis
Authors: Fu Linghua , Liu Xiao , Su Yuhao , Ma Jianyong , Hong Kui 
Published: December 2020

AbstractBackgroundThe exact prevalence and impact of cardiac injury in hospitalized patients with coronavirus disease 2019 (COVID‐19) is still controversial. Hence, we aim to investigate prevalence of cardiac injury and its impact on the outcomes in patients with COVID‐19.HypothesisCardiac injury is common and associated with higher risk of death.MethodsWe searched the Cochrane Library, PubMed, MedRxiv, and EMBASE databases from December 2019 to July 15, 2020 for studies that evaluated the prevalence and impact of cardiac injury on COVID‐19. This study has been registered with PROSPERO (International prospective register of systematic reviews)‐registration number‐CRD‐42020186120.ResultsTwenty‐one studies including 6297 participants were identified. The proportions of cardiac injury were 22%, 28% among hospitalized patients with COVID‐19 or severe COVID‐19 patients, respectively. The incidences of cardiac injury in advance age (>60 years) (30%) was about two‐fold than young patients (<60 years) (15%) with COVID‐19. Severe cases (42%) have seven‐fold prevalence cardiac injury than in their non‐ severe counterparts (6%). Furthermore, cardiac injury is associated with an increased risk of all‐cause mortality in patients with COVID‐19 (OR 10.11, 95% CI 4.49–22.77). In patients with severe COVID‐19, cardiac injury is associated with an increased risk of all‐cause mortality (OR: 16.79, 95% CI: 5.52–51.02).ConclusionsThis was the first meta‐analysis exploring the prevalence and impact of cardiac injury on COVID‐19. Cardiac injury is common in hospitalized patients and advanced age and severe COVID‐19 patients prone to experience more risk of cardiac injury. Furthermore, cardiac injury is associated with increased risk of all‐cause mortality.
Short‐term electric power load forecasting using factor analysis and long short‐term memory for smart cities
Authors: Veeramsetty Venkataramana , Chandra D. Rakesh , Salkuti Surender Reddy 
Published: December 2020

SummaryElectric load estimation is an important activity for electrical power system operators to operate the system stably and optimally. This paper develops a machine learning model with a long short‐term memory and a factor analysis to predict the load at a specific hour of the day on an electrical power substation. Historical load data from the 33‐/11‐kV substation near Kakatiya University in Warangal are taken at each hour of the day for the period from September 2018 to November 2018. A new long short‐term memory architecture with factor analysis is being designed based on the approach used to predict substation loads by simulation in Microsoft Azure Notebooks. Based on the study, it was found that the proposed design predicts loads with good accuracy.
A high efficiency soft‐switched DC–DC converter with high voltage conversion ratio
Authors: Shayeghi Hossein , Pourjafar Saeed , Hashemzadeh Seyed Majid , Blaabjerg Frede 
Published: December 2020

SummaryThis work proposes a kind of DC–DC topology with a higher voltage conversion ratio. The suggested converter utilizes a coupled inductor and a voltage multiplier cell to enhance the voltage conversion ratio. The voltage multiplier cell has the feature of the clamping circuit, which can decrease the maximum voltage of the semiconductors elements. In the presented structure, only one lower ON‐state resistance (RDS‐ON) power switch is utilized that makes the control circuit to be simple. The proposed converter has soft‐switching features such as zero‐current switching (ZCS) and zero voltage switching (ZVS) that lead to decrease the diodes reverse recovery losses and increase the efficiency. Besides, the ripple value of the input current is lower than the other similar works. The high efficiency and low input current ripple make the suggested converter suitable for photovoltaic (PV) applications. In order to approve the technical analysis of the recommended structure, technical investigations and comparison study with some similar structures are carried out. Finally, for demonstrating the advantages of the presented structure, a laboratory circuit is built with 12‐V DC source voltage, 120‐V load voltage, and power rate of 100 W in 50‐kHz operation frequency.
Unravelling the pore network and its behaviour: An integrated NMR, MICP, XCT and petrographical study of continental spring carbonates from the Ballık area, SW Turkey
Authors: Soete Jeroen , Claes Steven , Claes Hannes , Erthal Marcelle M. , Hamaekers Helen , De Boever Eva , Foubert Anneleen , Klitzsch Norbert , Swennen Rudy 
Published: December 2020

AbstractApplying an integrated methodology, including petrography, mercury injection capillary pressure, laboratory nuclear magnetic resonance and X‐ray computed tomography, on continental spring carbonate reservoir analogue samples is a prerequisite to understand plug scale porosity and permeability heterogeneities. Depending on the dominant pore type in a sample, the orientation and distribution of the pores, pore network connectivity varies from poor to excellent in these continental spring carbonates. The latter exhibit large‐scale ranges for both porosity (3%–25%) and permeability (0.004–3,675 mD). Facies classification alone proved insufficient to link porosity and permeability, due to intrafacies pore network variability. Better assessment of reservoir properties can be achieved by subdividing facies into lithotype and pore type classes. Obtained pore network data addresses the pore types, pore (throat) sizes, number of pore compartments, and allow a subdivision of the pore size distributions into unimodal, bimodal and atypical types. There is no micropore compartment present in samples with unimodal mercury injection capillary pressure and nuclear magnetic resonance distributions. Decoupled micropore compartments are observed in samples with bimodal mercury injection capillary pressure and nuclear magnetic resonance distributions, which show isolating calcite rims, and have limited permeabilities. The cement rims decrease the macropore connectivity and decouple the micropore compartments, which reside in micritic dendrites. The micropore compartment (r < 1 µm) is coupled with the mesopore (r = 1–15 µm) and macropore compartment (r > 15 µm) for atypical samples which lack pore‐lining calcite rims.
Intense pulsed light: The early years
Authors: Almukhtar Rawaa , Carr Emily , Goldman Mitchel 
Published: December 2020

AbstractBackgroundIntense pulsed light (IPL) is one of the most controversial and widely used light‐based technologies that had its origin in San Diego in 1992 and was approved by the US Food and Drug Administration in late 1995.AimsThe purpose of this review is to highlight the early years’ experience with IPL and development of its use over time.Material and MethodsArticles from PubMed on this subject were reviewed and clinical experience of the authors were shared.ResultsIPL was initially developed as an improved treatment for leg telangiectasias. Its ability to successfully treat vascular lesions while minimizing purpura, a common complication of pulsed dye lasers, as well as exfoliating superficial pigmented lesions and eliminating hair, extended the clinical utility of IPL to treat both pigmented and vascular lesions, providing the basis for its role in photo‐rejuvenation.DiscussionIPL is an effective and safe treatment modality for a wide range of dermatologic conditions from pigmented to vascular and inflammatory disorders.
Psychosocial predictors of eating classification in female athletes: From collegiate sport to retirement
Authors: Thompson Alexandra , Petrie Trent , Balcom Kayla , Tackett Bailey , Edward Watkins C. 
Published: December 2020

AbstractObjectiveDue to high prevalence, female athletes are considered a high‐risk group for eating disorders (i.e., clinical ED = 2.0% to 19.9%; subclinical ED = 7.1% to 49.2%). Cross‐sectional and longitudinal research have identified psychosocial factors that influence current and future disordered eating (e.g., appearance pressures, body satisfaction), but are limited in design (e.g., timeframe, active competitors). Quantitative evaluations of psychosocial predictors of female athletes' disordered eating in retirement are lacking.MethodThe current study investigated the predictive ability of psychosocial risk factors (e.g., body dissatisfaction, negative affect) from Time1, when collegiate female athletes were actively competing, to Time2, 6 years later when the women were retired (N = 194; Mage = 25.75 years [SD = 1.19]).ResultsFrom Time1 to Time2, 23.5% of the women who were Healthy moved to the Disordered classification; 51% remained in Disordered. The full model for athletes who maintained their Disordered status correctly classified 76% of the athletes. Dietary intent, pressure to exercise and change appearance, body satisfaction, and internalization significantly predicted athletes' maintenance as Disordered.DiscussionEarly intervention efforts that address appearance pressures, body image, and healthful eating when athletes are actively competing are vital to help alleviate future distress, particularly in retirement.
“This is just how I cope”: An inductive thematic analysis of eating disorder recovery content created and shared on TikTok using #EDrecovery
Authors: Herrick Shannon S. C. , Hallward Laura , Duncan Lindsay R. 
Published: December 2020

AbstractObjectiveTo explore eating disorder (ED) recovery‐related content created and shared on the social media platform TikTok.MethodA systematic review and inductive thematic analysis of 150 TikTok posts catalogued under hashtag (#) EDrecovery. Two coders independently analyzed the posts and a critical peer facilitated discussions about the resulting codes and themes.ResultsCreators on TikTok used #EDrecovery to share their personal experiences with recovery through the use and cooption of popular (or viral) video formats, succinct storytelling, and the production of educational content. Five themes were interpreted across the data: (a) ED awareness, (b) inpatient story time: “ED unit tings”, (c) eating in recovery, (d) transformations: “how about a weight gain glow up?”, and (e) trendy gallows humor: “let's confuse people who have a good relationship with food”.DiscussionTikTok as a user‐friendly, creative media may provide the artistic and social tools for some creators to add their distinct voice to the ED recovery narrative and foster some semblance of community. Although all of the analyzed content was catalogued under #EDrecovery, some of the posts reified the increasingly blurred boundary that exists between ED recovery and pro‐ED content on TikTok.
Development of an optical pressure‐sensitive membrane based on plasmon resonance on a gold island film
Authors: Takebayashi Nagato , Ikezawa Satoshi , Iwami Kentaro 
Published: December 2020

AbstractIn this paper, an optical pressure‐sensitive membrane based on plasmon resonance absorption has been designed, fabricated, and demonstrated. The membrane utilizes plasmon resonance on a gold island film embedded in a polydimethylsiloxane (PDMS) layers, and the shift of the resonant wavelength was used as an indicator of pressure‐induced strain of the membrane. The membrane with total thickness of 100 µm was prepared with spin‐coating of PDMS and vacuum evaporation of gold island film with the nominal thickness of 10 nm. Pressure sensitivity of the fabricated membrane was demonstrated from the measurement of absorbance spectra and the maximum sensitivity of 0.35 nm/kPa was achieved by applying pressure up to 35 kPa. Plasmon resonance mode attributing to the pressure sensitivity has been analyzed through comparison between electromagnetic simulation and membrane stretching test. From the stretching test, red shifts of the resonant wavelength were obtained for both parallel and perpendicular polarizations to the tensile direction with the sensitivities of 0.372 and 0.134 nm/%, respectively. From the electromagnetic simulation, these red shifts can be attributed to both gap‐mode and deformation‐mode resonances of the gold island film.
Effect of big eye tuna (Thunnusobesus) head soup with different colloidal particle size on TG and TC deposition in FFA‐exposed HepG2 cells
Authors: Zhang Jing , Lin Liu , Tao Ningping , Zhu Zheqing , Wang Xichang , Wang Mingfu 
Published: December 2020

AbstractMicro/nanocolloidal is confirmed as a self‐assembly structure in big eye tuna (Thunnus obesus) head soup, and lipids enriched with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the major component. In this study, the effect of big eye tuna head soup (BETHS) with different particle size micro/nanocolloidal on lipid accumulation was initially evaluated. The original soup and microfiltration soup (with or without ginger; OGS/OGSG and MFS/MFSG) were prepared firstly. A free fatty acid‐exposed (FFA‐exposed) HepG2 cell model was built using sodium oleic acid (OA) and sodium palmitic acid (PA) (2:1). The triglyceride (TG) and total cholesterol (TC) in the FFA‐exposed HepG2 cells were 8.6 ng/104 cells and 0.6 nM/104 cells, respectively, which were significantly different with control (p < .05). Both OGS and OGSG could significantly decline the TG deposition of FFA‐exposed HepG2 cells with 31% and 40% (p < .05), and in MFS and MFSG were 23% and 26% (p ≥ .05). Meanwhile, OGS inhibited the deposition of TG mainly in 18–24 hr, and OGSG mainly in 12–18 hr. All the BETHS samples showed no inhibition effect on TC deposition (p ≥ .05). This research might help to understand the improving activity of natural or traditional food products on metabolic syndrome.
The regulatory approval of anamorelin for treatment of cachexia in patients with non‐small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers.
Authors: Wakabayashi Hidetaka , Arai Hidenori , Inui Akio 
Published: December 2020

AbstractAnamorelin is a ghrelin receptor agonist that can be administered orally and thought to improve cancer cachexia by improving appetite and increasing serum insulin‐like growth factor‐1. Anamorelin was not approved for use in Europe. In contrast, the use of anamorelin for cancer cachexia in four types of cancer (non‐small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer) was approved in Japan on 11 December 2020. Phase 2 trial (ONO‐7643‐04) for the treatment of patients with non‐small cell lung cancer and cachexia resulted in 1.56 kg lean body mass increase assessed by dual‐energy X‐ray absorptiometry (DXA). Another study for advanced and unresectable gastrointestinal (colorectal, gastric, or pancreatic) cancer showed 1.89 ± 0.36 kg improvement in lean body mass. Skeletal lean body mass assessed by DXA is important for diagnosing sarcopenia and cachexia in Asia. The approval of anamorelin is expected to change clinical practice of cancer cachexia in Japan and hopefully in other countries. In the past, cachexia was rarely diagnosed in Japan, because it was often thought that cachexia meant terminal stage. The dissemination of clinical findings on anamorelin from Japan, as well as the creation of consensus papers and clinical practice guidelines for cachexia in Japan and Asia, will be required to promote international expansion in the future.
Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA
Authors: Orhan Ekim Onur , Irmak Özgür , Bal Emine Zeynep , Danacı Zeliha , Babayeva Fidan , Orhan Eren , Yücel Berk Can 
Published: December 2020

AbstractThe aim of this article was to investigate the unknown radiopacity performances of OrthoMTA and RetroMTA via means of a contemporary image analyzing methods and energy dispersive X‐ray spectroscopy. Three commercial hydraulic calcium silicate‐based cements and a calcium hydroxide‐based paste were used. Pure‐grade zirconium oxide, bismuth oxide, zinc oxide, barium sulfate, and calcium hydroxide were as references. An energy‐dispersive X‐ray spectroscopy instrument was used for the elemental analysis. Radiographic image data was obtained according to the International Organization for Standardization 6876‐2012 specifications. The region of interest was determined for each specimen. Mean (±SD) grey values of the X‐ray image data was measured with an image analyzing software. The calibration curve was created by curve‐plotting software and the mean grey‐values were matched versus Al values (mm Al). Data were analyzed with one‐way ANOVA followed by Tukey's multiple comparison test. Spectroscopic characterization of the commercial materials was shown with assigned Carbon, oxygen, aluminum, silicon, calcium, zinc, zirconium, barium, tungsten, bismuth, and sulfur elements. The major radiopacifier/s of OrthoMTA is Bi, of RetroMTA is Zr, of BioDentine are Ba and Zr, and of ProCal is Ba. The radiopacity values of all commercial materials are significantly different (p < .05). The rank of the radiopacity values: RetroMTA (3.36 ± 0.29mmAl) > OrthoMTA (2.56 ± 0.19mmAl) > BioDentine (2.02 ± 0.12mmAl) > ProCal (1.46 ± 0.60mmAl). The study reported that the radiopacity values and spectral characterization of RetroMTA and OrthoMTA cements. The pixel‐based and reproducible method could be used universally to the quantification of the radiodensity of digitally collected X‐ray data.
Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)‐Ambrisentan
Authors: Madhu Madasu , Doda Sai Reddy , Begari Prem Kumar , Dasari Krishna Rao , Thalari Gangadhar , Kadari Sudhakar , Yadav Jhillu Singh 
Published: December 2020

AbstractEnantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions are the key reactions.
The vitals of NETs
Authors: Tan Chuyi , Aziz Monowar , Wang Ping 
Published: December 2020

AbstractNeutrophils produce neutrophil extracellular traps (NETs) by expelling their extracellular chromatin embedded with citrullinated histone H3, myeloperoxidase, and other intracellular molecules. Since their discovery in 2004, numerous articles have demonstrated the mechanism of NET formation and their function in innate immunity and inflammation. NET components often play an antimicrobial role, but excessive NETs are deleterious and can cause inflammation and tissue damage. This review highlights recent advancements in the identification of novel pathways and mechanisms of NET formation. We also focus on the specific damaging impact of NETs in individual organs. We then discuss the progress and limitations of various NET detection assays. Collectively, these vital aspects of NETs significantly improve our understanding of the pathobiology of NETs and future diagnostics and therapeutic tools for examining and modulating NETs in inflammatory diseases.
Whole‐body magnetic resonance imaging for prostate cancer assessment: Current status and future directions
Authors: Van Nieuwenhove Sandy , Van Damme Julien , Padhani Anwar R. , Vandecaveye Vincent , Tombal Bertrand , Wuts Joris , Pasoglou Vassiliki , Lecouvet Frederic E. 
Published: December 2020

AbstractOver the past decade, updated definitions for the different stages of prostate cancer and risk for distant disease, along with the advent of new therapies, have remarkably changed the management of patients. The two expectations from imaging are accurate staging and appropriate assessment of disease response to therapies. Modern, next‐generation imaging (NGI) modalities, including whole‐body magnetic resonance imaging (WB‐MRI) and nuclear medicine (most often prostate‐specific membrane antigen [PSMA] positron emission tomography [PET]/computed tomography [CT]) bring added value to these imaging tasks. WB‐MRI has proven its superiority over bone scintigraphy (BS) and CT for the detection of distant metastasis, also providing reliable evaluations of disease response to treatment. Comparison of the effectiveness of WB‐MRI and molecular nuclear imaging techniques with regard to indications and the definition of their respective/complementary roles in clinical practice is ongoing. This paper illustrates the evolution of WB‐MRI imaging protocols, defines the current state‐of‐the art, and highlights the latest developments and future challenges. The paper presents and discusses WB‐MRI indications in the care pathway of men with prostate cancer in specific key situations: response assessment of metastatic disease, “all in one” cancer staging, and oligometastatic disease.
The effects of a novel non‐invasive application of platelet‐rich fibrin on periodontal clinical parameters and gingival crevicular fluid transforming growth factor‐β and collagen‐1 levels: A randomized, controlled, clinical study
Authors: Özcan Erkan , Saygun Işıl , Kantarcı Alpdogan , Özarslantürk Savaş , Serdar Muhittin A. , Özgürtaş Taner 
Published: December 2020

AbstractBackgroundSeveral potential benefits have been attributed to the platelet‐rich fibrin (PRF), including enhanced tissue healing properties. In this study, we hypothesized that the application of PRF as an adjunct to conventional scaling and root planing (ScRp) would enhance the outcomes of non‐surgical periodontal therapy.MethodsThe present study was a split‐mouth randomized controlled clinical trial design in 24 deep periodontal pockets in 12 patients with periodontitis. The pockets were randomly assigned as test or control. The test group received PRF as an adjunct to ScRp, whereas the control group received ScRp only. We measured periodontal clinical parameters at baseline, 3, and 6 months after the treatments. To study the initial healing in response to treatment, transforming growth factor‐β (TGF‐β) and collagen‐1 (Col‐1) in gingival crevicular fluid (GCF) were measured using enzyme‐linked immunosorbent assay at baseline, third, seventh, and 14th days.ResultsThe test group showed a significantly greater pocket reduction, higher clinical attachment gain, and less gingival recession than the control group at 3 and 6 months. The test Col‐1 levels (1.27 ± 1.05, 1.35 ± 0.76, 0.97 ± 0.53 ng/site) and TGF‐β levels (11.93 ± 2.68, 12.54 ± 3.66, 17.19 ± 11.66 pg/site) were higher than the control Col‐1 levels (0.76 ± 0.20, 0.84 ± 0.24, 0.57 ± 0.19 ng/site) and TGF‐β levels (6.34 ± 1.67, 6.35 ± 3.44, 7.51 ± 2.85 pg/site) at all measurement days respectively.ConclusionsNon‐surgical application of the PRF as an adjunct to conventional ScRp may effectively improve the periodontal clinical parameters via increasing expression of the GCF TGF‐β and Col‐1 levels.