bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence a shared mechanism mediates ipsi- and contralesional compensatory saccades and gait after unilateral vestibular deafferentation
Authors: Wagner Andrew R. , Schubert Michael C. 
Published: March 2020

The study objective was to understand how the contralesional labyrinth contributes to gaze and gait stability after unilateral vestibular deafferentation (UVD). Head impulse testing (vHIT) was completed in 37 individuals [22 women (59%); age 52.13 ± 11.59 yr, mean ± SD] with UVD from vestibular schwannoma resection. Compensatory saccades (CS) and vestibulo-ocular reflex (VOR) gain were analyzed for both ipsilesional and contralesional impulses. Gait speed (10-m walk test) and endurance (2-min walk test) were collected for 35 individuals. CS were recruited during contralesional head rotation regardless of VOR gain on either the ipsilesional [ρ = 0.21 (−0.14, 0.57); Spearman rank (95% confidence interval)] or contralesional side [ρ = −0.04 (−0.42, 0.35)]. Additionally, the latency of these CS (151.19 ± 52.41 ms) was similar to that of CS generated during ipsilesional rotation (165.65 ± 21.62 ms; P = 0.159). CS recruited during ipsilesional vHIT were of a higher velocity ( P < 0.001) and greater frequency ( P < 0.001) compared with contralesional CS. VOR gain asymmetry was significantly correlated with gait speed [ρ = −0.37 (−0.73, −0.01)], yet individual VOR gain was not correlated [ipsilesional: ρ = 0.17 (−0.20, 0.55); contralesional: ρ = −0.18 (−0.52, 0.15)]. Our data reveal CS are recruited at similar latencies without correlation to VOR gain or direction of head rotation, and that the central integration of ipsilesional and contralesional vestibular afference correlates with gait. Together, our data suggest the brain considers vestibular afference from both sides when generating related behavioral output after UVD. NEW & NOTEWORTHY After unilateral vestibular deafferentation, compensatory saccades (CS) have similar latencies regardless of the direction of head rotation, and those CS generated during contralesional head rotation are unrelated to extent of vestibular loss. Additionally, the extent of asymmetry in residual vestibular function, not the extent of vestibular loss, correlates with gait speed. Our data suggest a common mechanism is responsible for the generation of CS and restoration of gait speed in vestibular compensation.
Possible Limitations to the Role of Subsequent Agreements and Subsequent Practice – Viewed from Some State Practices
Authors: Hamamoto Yukiya 
Published: March 2020

Abstract
The International Law Commission completed its work on subsequent agreements and subsequent practice in relation to the interpretation of treaties. While acknowledging the importance of the work, this article attempts to highlight some issues that may limit treaty interpretation through subsequent agreements and subsequent practice. Concrete examples of treaties on the avoidance of double taxation and a treaty ending a war are used to illustrate such potential limitations.
Contributions to the Surface Downwelling Longwave Irradiance during Arctic Winter at Utqiaġvik (Barrow), Alaska
Authors: Sokolowsky G. Alexander , Clothiaux Eugene E. , Baggett Cory F. , Lee Sukyoung , Feldstein Steven B. , Eloranta Edwin W. , Cadeddu Maria P. , Bharadwaj Nitin , Johnson Karen L. 
Published: March 2020

AbstractIntrusions of warm, moist air into the Arctic during winter have emerged as important contributors to Arctic surface warming. Previous studies indicate that temperature, moisture, and hydrometeor enhancements during intrusions all make contributions to surface warming via emission of radiation down to the surface. Here, datasets from instrumentation at the Atmospheric Radiation Measurement User Facility in Utqiaġvik (formerly Barrow) for the six months from November through April for the six winter seasons of 2013/14–2018/19 were used to quantify the atmospheric state. These datasets subsequently served as inputs to compute surface downwelling longwave irradiances via radiative transfer computations at 1-min intervals with different combinations of constituents over the six winter seasons. The computed six winter average irradiance with all constituents included was 205.0 W m−2, close to the average measured irradiance of 206.7 W m−2, a difference of −0.8%. During this period, water vapor was the most important contributor to the irradiance. The computed average irradiance with dry gas was 71.9 W m−2. Separately adding water vapor, liquid, or ice to the dry atmosphere led to average increases of 2.4, 1.8, and 1.6 times the dry atmosphere irradiance, respectively. During the analysis period, 15 episodes of warm, moist air intrusions were identified. During the intrusions, individual contributions from elevated temperature, water vapor, liquid water, and ice water were found to be comparable to each other. These findings indicate that all properties of the atmospheric state must be known in order to quantify the radiation coming down to the Arctic surface during winter.
Use of the Autoregressive Integrated Moving Average (ARIMA) Model to Forecast Near-Term Regional Temperature and Precipitation
Authors: Lai Yuchuan , Dzombak David A. 
Published: March 2020

AbstractA data-driven approach for obtaining near-term (2–20 years) regional temperature and precipitation projections utilizing local historical observations was established in this study to facilitate civil and environmental engineering applications. Given the unique characteristics of temporal correlation and skewness exhibited in individual time series of temperature and precipitation variables, a statistical time series forecasting technique was developed based on the autoregressive integrated moving average (ARIMA) model. Annual projections obtained from the ARIMA model—depending on individual series—can be interpreted as an integration of the most recent observations and the long-term historical trend. In addition to annual temperature and precipitation forecasts, methods of estimating confidence intervals for different return periods and simulating future daily temperature and precipitation were developed to extend the applicability for use in engineering. Quantitative comparisons of annual temperature and precipitation forecasts developed from the ARIMA model and other common statistical techniques such as a linear trend method were performed. Results suggested that while the ARIMA model cannot outperform all other techniques for all evaluated climate indices, the ARIMA model in general provides more accurate projections—especially interval forecasts—and is more reliable than other common statistical techniques. With the use of the ARIMA-based statistical forecasting model, interpretable and reliable near-term, location-specific temperature and precipitation forecasts can be obtained for consideration of changing climate in civil and environmental engineering applications.
A Theoretical Note on Sector-specific FDI Inflow in Developing Economies and the Real Exchange Rate
Authors: Mandal Biswajit , Bhattacharjee Prasun 
Published: March 2020

Using a hybrid of the Heckscher–Ohlin model and specific factor model of trade, this article considers the phenomenon of FDI inflows only in the exportable sector of developing economies. We investigate the impact of such capital flow on factor prices and the real exchange rate (RER) in the host country. Our results indicate that the exportable production expands while both the non-traded good production and the return to the factor specific to the non-traded good decrease, consequent upon an inflow of capital specific to the exportable sector. The effect of such inflow of foreign capital on the RER is unambiguous and it increases. JEL Codes: F1, F21, F31
Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis
Authors: Rowan Aileen G. , Dillon Richard , Witkover Aviva , Melamed Anat , Demontis Maria-Antonietta , Gillet Nicolas A. , Mun Liew Jun , Bangham Charles R. M. , Cook Lucy B. , Fields Paul A. , Taylor Graham P. 
Published: March 2020

Abstract
Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic HTLV-1 infection, and the tumors carry both somatic mutations and proviral DNA integrated into the tumor genome. In order to gain insight into the oncogenic process, we used targeted sequencing to track the evolution of the malignant clone in 6 individuals, 2 to 10 years before the diagnosis of ATL. Clones of premalignant HTLV-1–infected cells bearing known driver mutations were detected in the blood up to 10 years before individuals developed acute and lymphoma subtype ATL. Six months before diagnosis, the total number and variant allele fraction of mutations increased in the blood. Peripheral blood mononuclear cells from premalignant cases (1 year prediagnosis) had significantly higher mutational burden in genes frequently mutated in ATL than did high-risk, age-matched HTLV-1 carriers who remained ATL-free after a median of 10 years of follow-up. These data show that HTLV-1–infected T-cell clones carrying key oncogenic driver mutations can be detected in cases of ATL years before the onset of symptoms. Early detection of such mutations may enable earlier and more effective intervention to prevent the development of ATL.
Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study
Authors: Royal Virginie , Leung Nelson , Troyanov Stéphan , Nasr Samih H. , Écotière Laure , LeBlanc Richard , Adam Benjamin A. , Angioi Andrea , Alexander Mariam P. , Asunis Anna Maria , Barreca Antonella , Bianco Paola , Cohen Camille , Drosou Maria E. , Fatima Huma , Fenoglio Roberta , Gougeon François , Goujon Jean-Michel , Herrera Guillermo A. , Knebelmann Bertrand , Lepori Nicola , Maletta Francesca , Manso Rita , Motwani Shveta S. , Pani Antonello , Rabant Marion , Rennke Helmut G. , Rocatello Dario , Rosenblum Frida , Sanders Paul W. , Santos Afonso , Soto Karina , Sis Banu , Touchard Guy , Venner Christopher P. , Bridoux Frank 
Published: March 2020

Abstract
Light chain cast nephropathy (LCCN) in multiple myeloma often leads to severe and poorly reversible acute kidney injury. Severe renal impairment influences the allocation of chemotherapy and its tolerability; it also affects patient survival. Whether renal biopsy findings add to the clinical assessment in predicting renal and patient outcomes in LCCN is uncertain. We retrospectively reviewed clinical presentation, chemotherapy regimens, hematologic response, and renal and patient outcomes in 178 patients with biopsy-proven LCCN from 10 centers in Europe and North America. A detailed pathology review, including assessment of the extent of cast formation, was performed to study correlations with initial presentation and outcomes. Patients presented with a mean estimated glomerular filtration rate (eGFR) of 13 ± 11 mL/min/1.73 m2, and 82% had stage 3 acute kidney injury. The mean number of casts was 3.2/mm2 in the cortex. Tubulointerstitial lesions were frequent: acute tubular injury (94%), tubulitis (82%), tubular rupture (62%), giant cell reaction (60%), and cortical and medullary inflammation (95% and 75%, respectively). Medullary inflammation, giant cell reaction, and the extent of cast formation correlated with eGFR value at LCCN diagnosis. During a median follow-up of 22 months, mean eGFR increased to 43 ± 30 mL/min/1.73 m2. Age, β2-microglobulin, best hematologic response, number of cortical casts per square millimeter, and degree of interstitial fibrosis/tubular atrophy (IFTA) were independently associated with a higher eGFR during follow-up. This eGFR value correlated with overall survival, independently of the hematologic response. This study shows that extent of cast formation and IFTA in LCCN predicts the quality of renal response, which, in turn, is associated with overall survival.
Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency
Authors: Troilo Arianna , Wehr Claudia , Janowska Iga , Venhoff Nils , Thiel Jens , Rawluk Justyna , Frede Natalie , Staniek Julian , Lorenzetti Raquel , Schleyer Marei-Theresa , Herget Georg W. , Konstantinidis Lukas , Erlacher Miriam , Proietti Michele , Camacho-Ordonez Nadezhda , Voll Reinhard Edmund , Grimbacher Bodo , Warnatz Klaus , Salzer Ulrich , Rizzi Marta 
Published: March 2020

Abstract
Common variable immunodeficiency (CVID) is a disease characterized by increased susceptibility to infections, hypogammaglobulinemia, and immune dysregulation. Although CVID is thought to be a disorder of the peripheral B-cell compartment, in 25% of patients, early B-cell development in the bone marrow is impaired. Because poor B-cell reconstitution after hematopoietic stem cell transplantation has been observed, we hypothesized that in some patients the bone marrow environment is not permissive to B-cell development. Studying the differentiation dynamics of bone marrow-derived CD34+ cells into immature B cells in vitro allowed us to distinguish patients with B-cell intrinsic defects and patients with a nonpermissive bone marrow environment. In the former, immature B cells did not develop and in the latter CD34+ cells differentiated into immature cells in vitro, but less efficiently in vivo. In a further group of patients, the uncommitted precursors were unable to support the constant development of B cells in vitro, indicating a possible low frequency or exhaustion of the precursor population. Hematopoietic stem cell transplantation would result in normal B-cell repopulation in case of intrinsic B-cell defect, but in defective B-cell repopulation in a nonpermissive environment. Our study points to the importance of the bone marrow niche in the pathogenesis of CVID.
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial
Authors: Jagasia Madan , Perales Miguel-Angel , Schroeder Mark A. , Ali Haris , Shah Nirav N. , Chen Yi-Bin , Fazal Salman , Dawkins Fitzroy W. , Arbushites Michael C. , Tian Chuan , Connelly-Smith Laura , Howell Michael D. , Khoury H. Jean 
Published: March 2020

Abstract
Patients who develop steroid-refractory acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic cell transplantation have poor prognosis, highlighting an unmet therapeutic need. In this open-label phase 2 study (ClinicalTrials.gov identifier: NCT02953678), patients aged at least 12 years with grades II to IV steroid-refractory aGVHD were eligible to receive ruxolitinib orally, starting at 5 mg twice daily plus corticosteroids, until treatment failure, unacceptable toxicity, or death. The primary end point was overall response rate (ORR) at day 28; the key secondary end point was duration of response (DOR) at 6 months. As of 2 July 2018, 71 patients received at least 1 dose of ruxolitinib. Forty-eight of those patients (67.6%) had grade III/IV aGVHD at enrollment. At day 28, 39 patients (54.9%; 95% confidence interval, 42.7%-66.8%) had an overall response, including 19 (26.8%) with complete responses. Best ORR at any time was 73.2% (complete response, 56.3%). Responses were observed across skin (61.1%), upper (45.5%) and lower (46.0%) gastrointestinal tract, and liver (26.7%). Median DOR was 345 days. Overall survival estimate at 6 months was 51.0%. At day 28, 24 (55.8%) of 43 patients receiving ruxolitinib and corticosteroids had a 50% or greater corticosteroid dose reduction from baseline. The most common treatment-emergent adverse events were anemia (64.8%), thrombocytopenia (62.0%), hypokalemia (49.3%), neutropenia (47.9%), and peripheral edema (45.1%). Ruxolitinib produced durable responses and encouraging survival compared with historical data in patients with steroid-refractory aGVHD who otherwise have dismal outcomes. The safety profile was consistent with expectations for ruxolitinib and this patient population.
Midgut microbiota diversity of potato tuber moth associated with potato tissue consumed
Authors: Zheng Yaqiang , Xiao Guanli , Zhou Wenwu , Gao Yulin , Li Zhengyue , Du Guangzu , Chen Bin 
Published: March 2020

Abstract
Background
The potato tuber moth (PTM), Phthorimaea operculella (Zeller), is a worldwide pest that feeds on both the leaves and tubers of potato plants. PTM larvae can digest leaves, or tubers, resulting in serious damage to potato plants in the field and potato tubers in storage. To understand how midgut bacterial diversity is influenced by the consumption of these two tissue types, the symbiotic bacteria in the potato-feeding PTM midgut and the endophytic bacteria of potato tissues were analyzed.

Results
At the genus level, the bacterial community composition in the PTM midgut was influenced by the tissues consumed, owing to their different nutrient contents. Escherichia_Shigella and Enterobacter were the most dominant genera in the midgut of leaf-feeding and tuber-feeding PTMs, respectively. Interestingly, even though only present in low abundance in leaves and tubers, Escherichia_Shigella were dominantly distributed only in the midgut of leaf-feeding PTMs, indicating that specific accumulation of these genera have occurred by feeding on leaves. Moreover, Enterobacter, the most dominant genus in the midgut of tuber-feeding PTMs, was undetectable in all potato tissues, indicating it is gut-specific origin and tuber feeding-specific accumulation. Both Escherichia_Shigella and Enterobacter abundances were positively correlated with the dominant contents of potato leaves and tubers, respectively.

Conclusions
Enrichment of specific PTM midgut bacterial communities was related to different nutrient levels in different tissues consumed by the insect, which in turn influenced host utilization. We provide evidence that a portion of the intestinal microbes of PTMs may be derived from potato endophytic bacteria and improve the understanding of the relationship between potato endophytic bacteria and the gut microbiota of PTMs, which may offer support for integrated management of this worldwide pest.
Heparin-binding protein measurement improves the prediction of myocardial injury-related cardiogenic shock
Authors: Pan Tuo , Long Guang-Feng , Chen Cheng , Zhang Hai-Tao , Wang Jun-Xia , Ahaskar Anshu , Chen Hong-Bing , Wang Dong-Jin 
Published: March 2020

Abstract
Background
Heparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcomes in patients with postoperative myocardial injury-related cardiogenic shock (MIRCS). We aimed to evaluate and validate HBP as a prognostic biomarker for postoperative MIRCS.

Methods
We performed a case-control study in 792 patients undergoing cardiac surgery from January 1, 2016, to August 1, 2019, including 172 patients with postoperative MIRCS and 620 age- and sex-matched controls. The association between HBP and MIRCS was determined by multivariate logistic regression analysis. Receiver operating characteristic curves (ROCs) with area under the curve (AUC) were performed to calculate the cut-off value, sensitivity and specificity. The association between HBP and cardiac troponin T (cTnT) was determined by multivariable linear regression analysis. Blood samples were drawn from the coronary sinus and arterial line of the cardiopulmonary bypass (CPB) before aortic cross-clamping (time point 1) and 5 min after aortic declamping (time point 2).

Results
Before aortic cross-clamping, coronary sinus HBP (HBPCS1) showed no differences between the two groups. However, after declamping, the MIRCS group had a significantly higher sinus HBP level (HBPCS2) than did the control group. HBPCS2 predicted MIRCS with an AUC of 0.85 (95% CI: 0.81–0.89, cut-off: 220 ng/ml, sensitivity: 92% and specificity: 70%). After adjusting for confounding factors, we found that HBP was an independent risk factor for MIRCS (OR: 7.65, 95% CI: 4.86–12.06, P < 0.01) and was positively associated with cTnT (β > 0, P < 0.01).

Conclusions
Elevated levels of coronary sinus HBP were useful biomarkers for predicting MIRCS after cardiac surgery.
Association between serum liver enzymes and hypertension: a cross-sectional study in Bangladeshi adults
Authors: Rahman Sadaqur , Islam Shiful , Haque Tangigul , Kathak Rahanuma Raihanu , Ali Nurshad 
Published: March 2020

Abstract
Background
Hypertension is a major contributing factor to cardiovascular disease and is a leading cause of death in the world. The association between hepatic enzymes and hypertension has been reported in limited studies and the findings are inconsistent; data from Bangladeshi adults are not available yet. This study was conducted to estimate the prevalence of elevated liver enzymes and evaluate the association of elevated liver enzymes with hypertension in Bangladeshi adults.

Methods
In this cross-sectional study, 302 blood samples were collected from adult participants and analyzed the serum concentrations of alanine and aspartate aminotransferase (ALT, AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (GGT) and other markers related to hypertension. Hypertension was defined as resting SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg. Associations between elevated liver enzymes and hypertension were evaluated by multinomial logistic regression.

Results
The mean concentrations of serum ALT, AST and GGT were significantly higher in the hypertensive group compared to the normotensive group (p < 0.01, p < 0.01 and p < 0.001, respectively). Overall, 49.2% of subjects in the hypertensive group and 38.1% of individuals in the normotensive group had at least one or more elevated liver enzymes. The prevalence of elevated ALT, AST, and GGT was significantly higher among participants in the hypertensive group compared to the normotensive group (p < 0.01, p < 0.01 and p < 0.001, respectively). An increasing trend for elevated liver enzymes was observed with increasing blood pressure. Serum ALT and GGT showed an independent relationship with hypertension.

Conclusions
The prevalence of elevated liver enzymes was higher in hypertensive individuals. Increased serum ALT and GGT activities were positively associated with hypertension in Bangladeshi adults.