bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
Authors: Cui Lu , Chen Shih-Yu , Lerbs Tristan , Lee Jin-Wook , Domizi Pablo , Gordon Sydney , Kim Yong-hun , Nolan Garry , Betancur Paola , Wernig Gerlinde 
Published: June 2020

AbstractThe transcription factor JUN is highly expressed in pulmonary fibrosis. Its induction in mice drives lung fibrosis, which is abrogated by administration of anti-CD47. Here, we use high-dimensional mass cytometry to profile protein expression and secretome of cells from patients with pulmonary fibrosis. We show that JUN is activated in fibrotic fibroblasts that expressed increased CD47 and PD-L1. Using ATAC-seq and ChIP-seq, we found that activation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We further detect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. Using an in vivo mouse model of fibrosis, we found two distinct mechanisms by which blocking IL-6, CD47 and PD-L1 reversed fibrosis, by increasing phagocytosis of profibrotic fibroblasts and by eliminating suppressive effects on adaptive immunity. Our results identify specific immune mechanisms that promote fibrosis and suggest a therapeutic approach that could be used alongside conventional anti-fibrotics for pulmonary fibrosis.
Photon deceleration in plasma wakes generates single-cycle relativistic tunable infrared pulses
Authors: Nie Zan , Pai Chih-Hao , Zhang Jie , Ning Xiaonan , Hua Jianfei , He Yunxiao , Wu Yipeng , Su Qianqian , Liu Shuang , Ma Yue , Cheng Zhi , Lu Wei , Chu Hsu-Hsin , Wang Jyhpyng , Zhang Chaojie , Mori Warren B. , Joshi Chan 
Published: June 2020

AbstractAvailability of relativistically intense, single-cycle, tunable infrared sources will open up new areas of relativistic nonlinear optics of plasmas, impulse IR spectroscopy and pump-probe experiments in the molecular fingerprint region. However, generation of such pulses is still a challenge by current methods. Recently, it has been proposed that time dependent refractive index associated with laser-produced nonlinear wakes in a suitably designed plasma density structure rapidly frequency down-converts photons. The longest wavelength photons slip backwards relative to the evolving laser pulse to form a single-cycle pulse within the nearly evacuated wake cavity. This process is called photon deceleration. Here, we demonstrate this scheme for generating high-power (~100 GW), near single-cycle, wavelength tunable (3–20 µm), infrared pulses using an 810 nm drive laser by tuning the density profile of the plasma. We also demonstrate that these pulses can be used to in-situ probe the transient and nonlinear wakes themselves.
A glioneuronal tumor with CLIP2-MET fusion
Authors: Chowdhury Tamrin , Lee Yeajina , Kim Sojin , Yu Hyeon Jong , Ji So Young , Bae Jeong Mo , Won Jae Kyung , Shin Joo Heon , Weinberger Daniel R. , Choi Seung Hong , Park Chul-Kee , Kim Jong-Il , Park Sung-Hye 
Published: June 2020

AbstractWe report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. We deliberated that MAPK pathway activation is one of the driver pathways responsible for the oncogenesis of GNT.
Observations of enhanced internal waves in an area of strong mesoscale variability in the southwestern East Sea (Japan Sea)
Authors: Noh Suyun , Nam SungHyun 
Published: June 2020

AbstractOceanic internal waves near the local inertial frequency or near-inertial internal waves and internal waves of tidal origin or internal tides are two types of low-frequency internal waves. Their interactions, interaction with background field, and resulting internal waves at higher frequencies beyond the near-inertial and tidal frequencies have rarely been reported despite its importance on ocean mixing and circulation of energy and materials. Here, we present five episodic enhancements of the high-frequency or continuum frequency waves (CFWs) observed in the southwestern East Sea (Japan Sea) and discuss causes for the enhanced CFWs in relation to near-inertial waves (NIWs), semidiurnal internal tides (SDITs), mesoscale flow fields, and their interactions. The NIWs were amplified due to local surface wind forcing, significantly interacting with mesoscale strain via wave capture. The SDITs were generated in a remote place and propagated into the observational site, largely depending on the mesoscale fields. The observational results suggest that the five episodes of CFWs are results of enhanced NIWs or SDITs, or their wave-wave interaction, rather than locally generated lee-waves. Our study suggests the significant impact of mesoscale circulation on the variability of internal waves from near-inertial to buoyancy frequencies through multiple pathways.
Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus
Authors: Zacheo Antonella , Hodek Jan , Witt Dariusz , Mangiatordi Giuseppe Felice , Ong Quy K. , Kocabiyik Ozgun , Depalo Nicoletta , Fanizza Elisabetta , Laquintana Valentino , Denora Nunzio , Migoni Danilo , Barski Piotr , Stellacci Francesco , Weber Jan , Krol Silke 
Published: June 2020

AbstractDengue virus (DENV) causes 390 million infections per year. Infections can be asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome. Currently, no effective antivirals or safe universal vaccine is available. In the present work we tested different gold nanoparticles (AuNP) coated with ligands ω-terminated with sugars bearing multiple sulfonate groups. We aimed to identify compounds with antiviral properties due to irreversible (virucidal) rather than reversible (virustatic) inhibition. The ligands varied in length, in number of sulfonated groups as well as their spatial orientation induced by the sugar head groups. We identified two candidates, a glucose- and a lactose-based ligand showing a low EC50 (effective concentration that inhibit 50% of the viral activity) for DENV-2 inhibition, moderate toxicity and a virucidal effect in hepatocytes with titre reduction of Median Tissue Culture Infectious Dose log10TCID50 2.5 and 3.1. Molecular docking simulations complemented the experimental findings suggesting a molecular rationale behind the binding between sulfonated head groups and DENV-2 envelope protein.
Navigated repetitive transcranial magnetic stimulation as preoperative assessment in patients with brain tumors
Authors: Motomura Kazuya , Takeuchi Hiroki , Nojima Ippei , Aoki Kosuke , Chalise Lushun , Iijima Kentaro , Wakabayashi Toshihiko , Natsume Atsushi 
Published: June 2020

AbstractWe aimed to investigate clinical parameters that affected the results of navigated repetitive transcranial magnetic stimulation (nrTMS) language mapping by comparing the results of preoperative nrTMS language mapping with those of direct cortical stimulation (DCS) mapping. In the prospective, non-randomized study, patients had to meet all of the following inclusion criteria: the presence of left- or right-side brain tumors in the vicinity of or inside the areas anatomically associated with language functions; awake brain surgery scheduled; and age >18 years. Sixty one patients were enrolled, and this study included 42 low-grade gliomas and 19 high-grade gliomas (39 men, 22 women; mean age, 41.1 years, range 18–72 years). The tumor was located in the left and right hemisphere in 50 (82.0%) and 11 (18.0%) patients, respectively. In the 50 patients with left-side gliomas, nrTMS language mapping showed 81.6% sensitivity, 59.6% specificity, 78.5% positive predictive value, and 64.1% negative predictive value when compared with the respective DCS values for detecting language sites in all regions. We then investigated how some parameters, including age, tumor type, tumor volume, and the involvement of anatomical language-related regions, affected different subpopulations. Based on the receiver operating curve statistics, subgroup analysis showed that the non-involvement of language-related regions afforded significantly better the area under the curve (AUC) values (AUC = 0.81, 95% confidence interval (CI): 0.74–0.88) than the involvement of language-related regions (AUC = 0.58, 95% CI: 0.50–0.67; p < 0.0001). Our findings suggest that nrTMS language mapping could be a reliable method, particularly in obtaining responses for cases without tumor-involvement of classical perisylvian language areas.
Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects
Authors: Lim Yi Rong Ivan , Preshaw Philip M. , Lim Lum Peng , Ong Marianne Meng Ann , Lin Hai-Shu , Tan Kai Soo 
Published: June 2020

AbstractResveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the comparative antimicrobial properties of RES and its analogues (pterostilbene [PTS], oxyresveratrol [OXY] and piceatannol [PIC]), utilizing 2-hydroxypropyl-β-cyclodextrin (HPβCD) as a solubiliser, which has a well-documented safety profile and FDA approval. These properties were investigated againstFusobacterium nucleatum, a key periodontal pathogen. PTS demonstrated the most potent antibacterial effects in HPβCD, with MIC > 60-fold lower than that of RES, OXY and PIC. In addition, PTS inhibitedF. nucleatumbiofilm formation. PTS exerted antimicrobial effects by eliciting leakage of cellular contents, leading to loss of bacterial cell viability. PTS also conferred immunomodulatory effects onF. nucleatum-challenged macrophages via upregulation of antioxidant pathways and inhibition of NF-κB activation. Given the superior antimicrobial potency of PTS againstF. nucleatumcompared to RES and other analogues, and coupled with its immunomodulatory properties, PTS complexed with HPβCD holds promise as a candidate nutraceutical for the adjunctive treatment of periodontitis.
Low temperature SiC die-attach bonding technology by hillocks generation on Al sheet surface with stress self-generation and self-release
Authors: Chen Chuantong , Suganuma Katsuaki 
Published: June 2020

AbstractThis paper introduced an approach of die-attach bonding technology based on a low-cost high-purity aluminum (99.99%) sheet in a silicon carbide (SiC)/direct bonded aluminum (DBA) power module. Both sides of an Al sheet were sputtered by a thin Ti and Ag layer, which generated a tensile stress of 166 MPa on the Al surface. After heating, the Al surface displayed a large quantity of Ag hillocks by stress self-release due to the coefficient of thermal expansion (CTE) mismatch among Al, Ti, and Ag. The SiC/Al sheet/DBA substrate interfaces were bridged by the generation of these hillocks, which correspond to a robust shear strength of 33.4 MPa in a low-temperature process. Hillocks generation and the interface bonding mechanism by surface stress self-generation and self-release were systematically analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The shear strength remains constant at 32.1 MPa after high-temperature storage at 250 °C for 500 h, which suggests that the Al sheet possesses excellent high-heat resistance and thermal stability. This novel approach of die-attach bonding technology serves as an attractive alternative for SiC power devices that require high-temperature performance.
Revisiting dual AGN candidates with spatially resolved LBT spectroscopy
Authors: Husemann B. , Heidt J. , De Rosa A. , Vignali C. , Bianchi S. , Bogdanović T. , Komossa S. , Paragi Z. 
Published: June 2020

Context.The merging of supermassive black holes (SMBHs) is a direct consequence of our hierarchical picture of galaxy evolution. It is difficult to track the merging process of SMBHs during mergers of galaxies as SMBHs are naturally difficult to observe.Aims.We want to characterise and confirm the presence of two independent active galactic nuclei (AGN) separated by a few kiloparsec in seven strongly interacting galaxies previously selected from the Sloan Digital Sky Survey (SDSS) as Seyfert-Seyfert pairs based on emission-line ratio diagnostics.Methods.Optical slit spectra taken with MODS at the Large Binocular Telescope are presented to infer the detailed spatial distribution of optical emission lines, and their line ratios and AGN signatures with respect to the host galaxies, thereby quantifying the impact of beam smearing and large fibre apertures on the spectra captured by the SDSS.Results.We find that at most two of the seven targets actually retain a Seyfert-Seyfert dual AGN, whereas the others may be more likely powered by post-AGB stars in retired galaxies or through shocks in the ISM based on spatially resolved optical line diagnostics. The major cause of this discrepancy is a bias caused by the spillover of flux from the primary source in the secondary SDSS fibre which can be more than an order of magnitude at < 3″ separations. Previously reported extremely low X-ray–to–[O III] luminosity ratios may be explained by this misclassification, as can heavily obscured AGN for the primaries. We also find that the nuclei with younger stellar ages host the primary AGN.Conclusions.Studies of close dual AGN selected solely from fibre-based spectroscopy can create severe biases in the sample selection and interpretation of the results. Spatially resolved spectroscopy should ideally be used in the future to characterise such compact systems together with multi-wavelength follow-up observations.
Die Analyse von Schnarchen bei Patienten mit obstruktiver Schlafapnoe (OSA) anhand von Polysomnografie und LEOSound
Authors: Moaeri S. , Hildebrandt O. , Cassel W. , Viniol C. , Schäfer A. , Kesper K. , Sohrabi K. , Gross V. , Koehler U. 
Published: June 2020

Zusammenfassung
Einleitung In dieser Studie wird bei Patienten mit OSA parallel zur Erfassung des Biosignals Schnarchen aus der Polysomnografie auch eine akustische Aufzeichnung mit dem LEOSound (akustische Langzeitregistrierung der Atem- und Atemnebengeräusche) durchgeführt. Es stellt sich die Frage, wie viele der obstruktiven Apnoen bei apnoeterminierender Wiederaufnahme der Atmung mit Schnarchen einhergehen.
Methode Parallel zur polysomnografischen Messung wurde bei 40 Patienten mit OSA (AHI > 15/h) eine Atem- und Atemnebengeräuschaufzeichnung mit dem LEOSound-Rekorder durchgeführt. Das durchschnittliche Alter der Patienten lag bei 57 ± 11 Jahren. Das durchschnittliche Körpergewicht betrug 100 ± 19 kg bei einem mittleren Body-Mass-Index (BMI) von 33 ± 7 kg/m2. 12 der 40 Aufzeichnungen mussten aufgrund qualitativ unzureichender Messqualität von der Bewertung ausgeschlossen werden. Die visuell detektierten Schnarchereignisse in der Polysomnografie wurden mit den audiovisuell erfassten im LEOSound verglichen.
Ergebnisse Insgesamt konnten 3778 obstruktive Apnoephasen registriert werden. In der Polysomnografie gingen 2229 (58,8 %) Apnoen mit Schnarchen einher, in der akustischen Messung 1921 (51,0 %). Bei einem der Patienten war eine ausgeprägtere Abweichung der Frequenz der Schnarchereignisse von PSG und LEOSound nachweisbar.
Diskussion Schnarchen wird in beiden Verfahren bei etwa 60 % der obstruktiven Apnoephasen gefunden. Eine audiovisuelle Beurteilung von Schnarchen ist mittels Geräuschaufzeichnung sehr zuverlässig durchführbar. Es bedarf der weiteren Klärung, warum nur 60 % der apnoeterminierenden Hyperpnoen mit Schnarchen einhergehen. Pathophysiologisch wäre zu erwarten, dass das Öffnen des obstruierten Atemwegs in einem sehr viel höheren Prozentsatz mit einer turbulenten Strömung, Weichteilschwingung und damit auch Schnarchen kombiniert ist.
Paraneoplastisches Cushing-Syndrom als Ursache von therapierefraktärer Hypokaliämie
Authors: Gerhardt Louisa M. S. , Sabath Lisa , Müller Beat , Capraro Joel , Borm Katrin 
Published: June 2020

Zusammenfassung
Anamnese und klinischer Befund Ein 58-jähriger Mann stellte sich mit therapierefraktärer Hypokaliämie und rascher Gewichtszunahme vor. Klinisch bestanden hypertensive Blutdruckwerte, eine stammbetonte Adipositas und ausgeprägte Beinödeme.
Untersuchungen und Diagnose Die Laboruntersuchungen ergaben eine hypokaliämische metabolische Alkalose bei ACTH-abhängigem Hyperkortisolismus. Die Thorax-Abdomen-CT zeigte eine pulmonale Raumforderung und eine Raumforderung der rechten Nebenniere. Bioptisch wurde die Diagnose eines ACTH-produzierenden kleinzelligen Lungenkarzinoms gestellt.
Therapie und Verlauf Unter Therapie mit Ketoconazol und Chemotherapie war der Tumor größenregredient, der Hyperkortisolismus konnte kontrolliert werden. Die Raumforderung der rechten Nebenniere war im Verlauf größenkonstant, sodass wir von einem inzidentellen Nebennierenadenom ausgingen.
Folgerung Die Diagnose des paraneoplastischen Cushing-Syndroms kann eine Herausforderung sein, da klassische Cushing-Stigmata aufgrund des raschen Auftretens fehlen können. Bei neu aufgetretener, therapierefraktärer Hypokaliämie, metabolischer Alkalose und arterieller Hypertonie sollte man daher nicht zuletzt an Hyperkortisolismus denken.
Hemodynamic and Pressor Responses to Combination of Yoga and Blood
Flow Restriction
Authors: Wooten Savannah V. , Stray-Gundersen Sten , Tanaka Hirofumi 
Published: June 2020

AbstractA combination of yoga and blood flow restriction, each of which elicits marked
pressor responses, may further increase blood pressure and myocardial oxygen
demand. To determine the impact of a combination of yoga and blood flow
restriction on hemodynamic responses, twenty young healthy participants
performed 20 yoga poses with/without blood flow restriction bands placed
on both legs. At baseline, there were no significant differences in any of the
variables between the blood flow restriction and non-blood flow restriction
conditions. Blood pressure and heart rate increased in response to the various
yoga poses (p<0.01) but were not different between the blood flow
restriction and non-blood flow restriction conditions. Rate-pressure products,
an index of myocardial oxygen demand, increased significantly during yoga
exercises with no significant differences between the two conditions. Rating of
perceived exertion was not different between the conditions. Blood lactate
concentration was significantly greater after performing yoga with blood flow
restriction bands (p=0.007). Cardio-ankle vascular index, an index of
arterial stiffness, decreased similarly after yoga exercise in both conditions
while flow-mediated dilation remained unchanged. In conclusion, the use of lower
body blood flow restriction bands in combination with yoga did not result in
additive or synergistic hemodynamic and pressor responses.
Wart Treated with Constitutional Homoeopathic Remedy Natrum muriaticum: A Case Study
Authors: Garg Arvindra Kumar , Agarwal Neha 
Published: June 2020

AbstractWart is a common problem in younger and elder persons. Most of the warts are seen on neck, face and armpit. Practically there is no complaint due to wart, but it causes cosmetic problem so there is need for treatment. The best way to treat them is by homoeopathic medicines. Other methods like burning and cutting can cause more harm than help. Here I am presenting a case of warts that is treated very beautifully with Natrum muriaticum.
Linking Emotional Intelligence to Successful Health Care Leadership: The Big Five Model of Personality
Authors: Cavaness Keith , Picchioni Anthony , Fleshman James W. 
Published: June 2020

AbstractResearch has identified emotional intelligence as the ability to understand and manage emotions. This is especially important for surgical leaders who must interact constructively with teams, administrators, patients, colleagues, and the community. Conventional intelligence emphasizes the rational and analytical brain. When one becomes aware of emotional intelligence, it adds to the repertoire of the surgical leader. It gives them insight into the dynamics of interpersonal relationships. This will allow the surgeon to control the emotional side of communication. Specifically, emotional intelligence focuses on self-awareness, self-management, social skills, and resiliency. With these skills, they are able to modulate their leadership style, allowing for increased conflict management and persuasiveness, more effective change management, and consensus-building. Emotional intelligence is not innate; these are learned skills. With practice and attention, it is possible to acquire the skills to enhance relationships.
Surgical Leadership
Authors: Peters Walter , Picchioni Anthony , Fleshman James W. 
Published: June 2020

AbstractThere are few topics of more importance in health care today than surgical leadership. The surgical leader will need to organize and maintain a collective effort if the organization is going to be effective. Health care teams work in a volatile, uncertain, complex, and ambiguous ecosystem. Therefore, surgeons must develop skills beyond the operating room. The facilitative leader will lead from the middle, not the top. They will empower coworkers to participate in creating a vision by building consensus, developing teams, clarifying roles, and earning the loyalty and trust of their colleagues. Surgical leaders will use communication as the vehicle for their success, including intentional listening, asking open-ended questions, and creating dialog instead of argumentative exchanges. The future of health care belongs to the physicians who are investing the time and effort today to become leaders.
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
Authors: Aprile Francesco A. , Sormanni Pietro , Podpolny Marina , Chhangur Shianne , Needham Lisa-Maria , Ruggeri Francesco S. , Perni Michele , Limbocker Ryan , Heller Gabriella T. , Sneideris Tomas , Scheidt Tom , Mannini Benedetta , Habchi Johnny , Lee Steven F. , Salinas Patricia C. , Knowles Tuomas P. J. , Dobson Christopher M. , Vendruscolo Michele 
Published: June 2020

Significance
The accurate quantification of the amounts of small oligomeric assemblies formed by the amyloid β (Aβ) peptide represents a major challenge in the Alzheimer’s field. There is therefore great interest in the development of methods to specifically detect these oligomers by distinguishing them from larger aggregates. The availability of these methods will enable the development of effective diagnostic and therapeutic interventions for this and other diseases related to protein misfolding and aggregation. We describe here a single-domain antibody able to selectively quantify oligomers of the Aβ peptide in isolation and in complex protein mixtures from animal models of disease.
Fruit and seed production.
Authors: Wehner Todd C. , Naegele Rachel P. , Myers James R. , Dhillon Narinder P. S. , Crosby Kevin 
Published: June 2020

Abstract

This chapter deals with some aspects of fruit and seed production of cucurbit crops, such as cucumber, melon, squash and watermelon. The control of sex expression, pollination, harvesting, postharvest handling and storage (fruits and seeds) are discussed.