bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a nomogram to predict depression in older adults with heart disease: a national survey in China
Authors: Ding Xianghong , Shi Zijuan , Xiang Liping , Liu Qin , Wu Li , Long Qingwen , Lee Yujun 
Published: December 2024

BackgroundComorbid depression, frequently observed in heart disease patients, has detrimental effects on mental health and may exacerbate cardiac conditions. The objective of this study was to create and validate a risk prediction nomogram specifically for comorbid depression in older adult patients suffering from heart disease.MethodsThe 2018 data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) was analyzed and 2,110 older adult patients with heart disease aged 60 and above were included in the study. They were randomly divided in a 7:3 ratio into a training set (n = 1,477) and a validation set (n = 633). Depression symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) and the participants were categorized into depressed (n = 687) and non-depressed (n = 1,423) groups. We collected information regarding general demographics, lifestyle habits, and medical history of the included patients. LASSO regression and binary logistic regression analyses were performed to identify independent risk factors and construct the depression prediction nomogram. Receiver operating characteristic curve analysis and the Hosmer-Lemeshow test were used to assess the model's discrimination and calibration. Decision curve analysis helped evaluate the clinical utility of the predictive nomogram.ResultsBased on the LASSO and multivariable regression analyses, education level, quality of life, sleep quality, frequency of watching TV, and history of arthritis were identified as independent risk factors for comorbid depression in the older adult heart disease patients. A nomogram model was constructed with these five independent risk factors. The nomogram showed good clinical performance with an area under the curve (AUC) value of 0.816 (95% CI: 0.793 to 0.839). The calibration curves and Hosmer-Lemeshow goodness-of-fit test (training set χt2 = 4.796, p = 0.760; validation set χv2 = 7.236, p = 0.511) showed its satisfactory. Clinical usefulness of the nomogram was confirmed by decision curve analysis.ConclusionsA five-parameter nomogram for predicting depression in older adult heart disease patients was developed and validated. The nomogram demonstrated high accuracy, discrimination ability, and clinical utility in assessing the risk of depression in the older adult patients with heart disease.
The relationship between organizational trust and voice behavior among neonatal intensive care unit nurses in tertiary A hospitals in Sichuan Province: the mediating role of career resilience
Authors: Zhang Xiujuan , Huang Xi , Hu Yanling , Chen Qiong , Zhao Xiufang 
Published: December 2024

BackgroundNeonatal intensive care unit (NICU) nurses face immense pressure, yet research on their voice behavior and the motivational mechanisms behind it is limited. Specifically, the impact of organizational trust and career resilience on this behavior has not been thoroughly explored.AimThis study aims to examine the relationship between organizational trust and voice behavior in NICU nurses, with career resilience acting as a mediating factor, providing empirical evidence for nursing management.MethodsA multicenter cross-sectional survey was conducted from January to June 2023, involving 422 neonatal nurses from tertiary hospitals in Sichuan Province, China. Data were collected using a self-designed questionnaire, a voice behavior scale, an organizational trust scale, and a career resilience scale. Hierarchical regression and structural equation modeling (SEM) were employed to analyze the relationships among the variables.ResultsHierarchical regression analysis revealed that organizational trust (β = 0.28, p &lt; 0.001) and career resilience (β = 0.45, p &lt; 0.001) significantly predicted voice behavior. Mediation analysis using structural equation modeling confirmed that career resilience mediated the relationship between organizational trust and voice behavior, with a mediation effect of 0.340, accounting for 44.8% of the total effect. The structural model demonstrated good fit indices (CFI = 0.962, RMSEA = 0.045), indicating the robustness of the proposed model.ConclusionOrganizational trust significantly influences NICU nurses’ voice behavior, with career resilience playing a critical mediating role. Enhancing organizational trust and fostering career resilience among NICU nurses can improve their willingness to engage in voice behavior, ultimately leading to better healthcare outcomes.Implications for nursing managementNursing managers should foster a trusting and supportive work environment to improve nurses’ job satisfaction and organizational commitment. This can be achieved by enhancing psychological empowerment and promoting positive interactions between nurses, the organization, and leadership. Such an environment helps reduce burnout and strengthens career resilience. Increased resilience enables nurses to better manage clinical pressures and challenges, elevating their career expectations and enhancing their willingness to engage in work. This, in turn, promotes innovation, active participation, and improved voice behavior, ultimately contributing to organizational success.
Growth assessment of croakers (Pseudotolithus species) in West African waters
Authors: Mahe Kelig , Ekperusi Abraham O. , Diouf Khady , Munschy Catherine , Aminot Yann , Andrialovanirina Nicolas , Dussuel Antoine , Diop Mamadou 
Published: December 2024

IntroductionThe genus Pseudotolithus, commonly called croaker, is represented by the three main species found in West African waters.MethodsIn total, 934 individuals were sampled in 8 locations in Senegal, Ghana, and Nigeria. Several tests identified using sectioned otolith as the best method for determining the croakers' age. The marginal increment analysis validated the age data.ResultsThe relationship between total length and total weight was significant for all species. This relationship is significantly different according to the geographical area. There was significant sexual dimorphism in P. senegalensis and P. typus, and the reproduction period presented a significant effect on the body length-weight relationship of P. senegalensis. The von Bertalanffy growth model constrained by t0 = 0 was the best fit for the observed age data from the three species in the sampled countries. The asymptotic length TL∞ was estimated from 26.6 cm for P. elongatus on the Nigerian coast to 42.2 cm for P. senegalensis on the Senegalese coast. The growth rate K ranged from 0.58 for P. senegalensis to 1.12 for P. typus.DiscussionThe growth was significantly different among the three sampled countries for P. senegalensis. Conversely, there was no significant difference of growth between specimens of P. typus from Nigeria and Ghana. Finally, there was no significant sexual dimorphism in the growth of P. senegalensis in Senegalese waters. This new information on the biology of these three croaker species is essential for the future assessment and management of these commercial species in West African waters.
Collinear Fractals and Bandt’s Conjecture
Authors: Espigule Bernat , Juher David , Saldaña Joan 
Published: December 2024

For a complex parameter c outside the unit disk and an integer n≥2, we examine the n-ary collinear fractal E(c,n), defined as the attractor of the iterated function system {fk:C⟶C}k=1n, where fk(z):=1+n−2k+c−1z. We investigate some topological features of the connectedness locus Mn defined as the set of those c for which E(c,n) is connected. In particular, we provide a detailed answer to an open question posed by Calegari, Koch, and Walker in 2017. We also extend and refine the technique of the “covering property” by Solomyak and Xu to any n≥2. We use it to show that a nontrivial portion of Mn is regular closed. When n≥21, we enhance this result by showing that in fact, the whole Mn∖R lies within the closure of its interior, thus proving that the generalized Bandt’s conjecture is true.
Therapeutic Potential of Glutathione Augmentation in Cancer Patients Receiving Chemotherapy or Radiotherapy
Authors: Gutman Jimmy 
Published: December 2024

Abstract:
The majority of cancer patients receiving conventional medical therapy receive chemotherapy, radiotherapy, surgery or palliative support. Nutritional support is increasingly recognized as vital to successful treatment. Glutathione (GSH) is a naturally-occurring tripeptide in human cells that serves many important functions, including antioxidant regulation, detoxification, protein synthesis and repair, immune modulation, and redox signaling. Altering glutathione levels has been demonstrated to have significant effects in chemotherapy/radiotherapy outcomes as well as influence on retarding cachexia. This review article summarizes some of the most notable findings, suggesting that up-regulation of glutathione through nutritional intervention has a potential to be integrated into a holistic approach to cancer treatment.
Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients
Authors: Fu Zhen Ming , Xu Hong Xia , Song Chun Hua , Li Wei , Guo Zeng Qing , Lin Yuan , Shi Ying Ying , Hu Wen , Ba Yi , Li Su Yi , Li Zeng Ning , Wang Kun Hua , Wu Jing , He Ying , Yang Jia Jun , Xie Cong Hua , Song Xin Xia , Chen Gong Yan , Ma Wen Jun , Luo Su Xia , Chen Zi Hua , Cong Ming Hua , Ma Hu , Zhou Chun Ling , Wang Wei , Luo Qi , Shi Yong Mei , Qi Yu Mei , Jiang Hai Ping , Guan Wen Xian , Chen Jun Qiang , Chen Jia Xin , Fang Yu , Zhou Lan , Feng Yong Dong , Tan Rong Shao , Li Tao , Ou Jun Wen , Zhao Qing Chuan , Wu Jian Xiong , Wang Chang , Shi Han Ping ,   The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group
Published: December 2024

Abstract:
The prevalence of malnutrition is high among oncology patients in China. Although the Patient-Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types.
Bioelectrical Impedance Phase Angle as a Predictors of Mortality in Patients with Lung Cancer: a Prospective Study
Authors: Guo Jing , Chong Fei Fei , Yin Liang Yu , Lin Xin , Zhang Meng Yuan , Shi Mu Li , Zhang Hong Mei , Liu Jie , Xu Hong Xia , Kang Jun 
Published: December 2024

Abstract:

Objective
Bioelectrical impedance analysis (BIA) is used to measure a patient’s body composition. The phase angle (PA), the major parameter in BIA, is one of the most sensitive indicators of malnutrition. The aim of the current study was to investigate whether the PA can be used to predict survival in lung cancer patients.

Methods
One hundred sixty-six lung cancer patients were prospectively included from January 2014 to August 2016 in Daping Hospital. Anthropometric measurements, hematological values, the nutritional risk screening (NRS 2002) score, patient generated-subjective global assessment (PG-SGA) score, Karnofsky performance status (KPS) scale, European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ C-30) score, and BIA were investigated within 48 hours after admission to the hospital. A Spearman correlation analysis was applied to test the correlations between the study characteristics and PA. A Kaplan-Meier analysis and log-rank test were conducted to analyze the association between the overall survival (OS) and PA.

Results
The mean age for all patients was 63 years old (42 females and 124 males). The median PA was 5.5°(4.70°, 6.23°). The PA was positively associated with the body mass index, hand grip strength, mid-arm circumference, mid-arm muscle circumference, albumin, prealbumin, C-reactive protein, red blood cells, hemoglobin and KPS score. The PG-SGA scores, QLQ-C30 score, and NRS2002 score showed a significant negative association with the PA. According to a multivariate analysis, the PA (HR = 0.47; 95% CI: 0.27-0.81) was independent predictor of the lung cancer patients’ long-term OS. Patients with a higher PA (≥ 5°) had better overall survival (median = 426 days) compared to those with a lower PA (< 5°) (median = 96 days) based on the one-year follow-up data (P < 0.0001).

Conclusions
These studies indicate that the PA is a sensitive and early indicator to predict survival in lung cancer patients.
Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients
Authors: Chong Fei Fei , Yin Liang Yu , Liu Jie , Li Na , Guo Jing , Fan Yang , Zhang Meng Yuan , Zhang Ling , He Xiu Mei , Zhang Hong Mei , Shi Mu Li , Li Wei , Xu Hong Xia ,   The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group
Published: December 2024

Abstract:

Background
The Global Leadership Initiative on Malnutrition (GLIM) recently developed a new set of diagnostic criteria for identifying patients with malnutrition. Because the GLIM criteria were only introduced a little over 3 years ago, additional validation and reliability testing are needed in a variety of populations.

Methods
We performed an observational, multicenter cohort study. From July 2013 to October 2018, lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project. Previously-established cut-off values for the calf circumference (CC, male < 30 cm, female < 29.5 cm) were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis. Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.

Results
A total of 1219 patients with lung cancer were studied as subjects. Their age was 58.81 ± 9.92 years old, and 820 were male and 399 were female. According to the GLIM diagnostic criteria using the CC as a muscle mass measurement, 303 patients (24.9%) were categorized as malnourished, 142 patients (23.1%) in the adult group (18 ≤ age < 60) and 161 patients (26.7%) in the older group (age ≥ 60 years). The patients with malnutrition had a higher incidence of anemia than the nourished patients (P = 0.012). The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group (all P < 0.001). The median survival of the malnutrition group was 42 (95% CI: 34-50) months, which was much shorter than the 62 (95% CI: 57-66) months in the nourished group (P < 0.001). In the adult group, the median survival decreased from 65 (95% CI: 55-72) months in nourished group to 34 (95% CI: 25-48) months in the patients with malnutrition (P < 0.001). In the older group, it decreased from 61 (95% CI: 55-67) months to 48 (95% CI: 39-59) months (P = 0.001). A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group (HR = 1.670, 95% CI: 1.29-2.16), older group (HR = 1.332, 95% CI: 1.05-1.69) and overall (HR = 1.453, 95% CI: 1.22-1.72).

Conclusion
All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients, independent of age.
Actualización sobre el diagnóstico y tratamiento del síndrome de aspiración de meconio
Authors: Vargas Cedeño Juan Diego , Marín Zúñiga Josué , Carvajal Barboza Fiorella 
Published: December 2024

El Síndrome de Aspiración de Meconio (SAM) es una entidad caracterizada por dificultad respiratoria que sucede en pacientes que nacen a través de líquido amniótico meconizado, cuyos síntomas no pueden explicarse de otra manera. El SAM puede presentarse con diversos grados de severidad, desde una condición leve hasta ser potencialmente mortal con insuficiencia respiratoria y secuelas permanentes. Su fisiopatología involucra el paso o aspiración de meconio de manera intrauterina o postnatal con posterior enfermedad pulmonar que resulta en hipoxemia, acidosis y, potencialmente, hipertensión arterial pulmonar. El SAM se diferencia de otras causas de dificultad respiratoria neonatal según los antecedentes del paciente, la historia clínica, el examen físico y los hallazgos radiográficos. En esta revisión bibliográfica se revisa la presentación clínica y evaluación diagnóstica que debe realizarse, además se pretende direccionar el manejo médico y ventilatorio a seguir debido a las mejoras en la reanimación neonatal durante los últimos años. Estos cambios recientes han contribuido con la disminución de su incidencia y gravedad, sin embargo, aún se necesitan más estudios controlados aleatorizados para la optimización de la atención de los lactantes no vigorosos con SAM.
Susceptibilidad inmunológica a las infecciones virales de vía aérea posterior a la pandemia de COVID-19
Authors: Salazar Rodríguez Sender , Dozier Nadia Luella , Campos Paredes Melissa , Van den Boogaard Tessa , Vargas Acuña Elena 
Published: December 2024

La susceptibilidad inmunológica a las infecciones virales de vía aérea posterior a la pandemia covid-19 se ha relacionado a la disminución en la propagación de estos virus producto de las intervenciones no farmacéuticas implementadas durante la pandemia. El distanciamiento social, el confinamiento y el uso de mascarilla permitió limitar la cadena de transmisión respiratoria; disminuyendo el SARS-COV-2 y concomitantemente otros virus respiratorios como Influenza y Virus Respiratorio Sincicial. Sin embargo, este efecto beneficioso durante la pandemia COVID-19 es el responsable hoy en día de una disminución en la inmunidad colectiva contra ellos. La escasa exposición a estos virus respiratorios podría culminar en epidemias virales más graves futuramente así como un alza en la incidencia de otros virus respiratorios. El papel del sistema inmunológico tiene una implicación importante en esta susceptibilidad inmune sucedida posterior a la pandemia covid-19. Este sistema es la primera línea de defensa del cuerpo humano mediante el sistema inmune innato y adaptativo. La presente revisión, busca establecer la relación entre la susceptibilidad inmunológica a los virus respiratorios y la pandemia COVID-19; mediante la identificación de los factores asociados al alza de incidencia de virus respiratorios; así como la respuesta del sistema inmunológico ante estos virus. Además, de determinar la prevalencia etiológica de los principales virus ante esta susceptibilidad posterior a la pandemia COVID-19.
Направления совершенствования государственно-частного партнерства в Республике Башкортостан
Authors: Зайнашева З.Г. 
Published: December 2024

Государственно-частное партнерство (ГЧП) приобретает большую значимость в контексте стратегии импортозамещения, концепция которой активно развивается на федеральном уровне. В эпоху глобализации санкции создали серьезные вызовы, которые вынуждают искать пути для обеспечения собственной экономической устойчивости и независимости, и в данной ситуации ГЧП выступает ключевым инструментом для решения ряда задач, позволяя привлекать частные инвестиции в отрасли, требующие значительных финансовых вложений и технологических инноваций. Целью исследования является определение направлений дальнейшего развития государственно-частного партнерства в регионе, а задачами - выявление проблем в развитии ГЧП; предложение направлений совершенствования ГЧП в регионе. В процессе выполнения исследования использованы методы экспертных оценок, программно-целевого, системного и комплексного подходов.
Public-private partnership (PPP) is becoming more important in the context of the import substitution strategy, the concept of which is actively developing at the federal level. In the era of globalization, sanctions have created serious challenges that force us to look for ways to ensure our own economic stability and independence, and in this situation, PPP acts as a key tool for solving a number of tasks, namely, it allows us to attract private investment in industries that require significant financial investments and technological innovations. The purpose of the study is to identify areas for further development of public-private partnership in the region, and the objectives are to identify problems in the development of PPP; to propose ways to improve PPP in the region. In the course of the research, the methods of expert assessments, program-oriented, systemic and integrated approaches were used.
Повышение эффективности инструментов менеджмента и процесса их реализации на субъектах хозяйствования инфраструктуры железнодорожной отрасли
Authors: Козлов В.С. 
Published: December 2024

В статье рассматриваются теоретические аспекты методологии управления процессом ведения анализа и обоснование применяемых инструментов менеджмента на предприятиях железнодорожного транспорта. Акцент сделан на информационном развитии процессов управления и обработки данных для повышения качества управленческих решений.
The article discusses the theoretical aspects of the methodology of management of the analysis process and the justification of the management tools used at railway transport enterprises. The emphasis is on the information development of management and data processing processes to improve the quality of management decisions.