bluuebunny/crossref_metadata_2025_split huggingface dataset:
A gradient boosting decision tree algorithm combining synthetic minority oversampling technique for lithology identification
Authors: Zhou Kaibo , Zhang Jianyu , Ren Yusong , Huang Zhen , Zhao Luanxiao 
Published: January 2020

Lithology identification based on conventional well-logging data is of great importance for geologic features characterization and reservoir quality evaluation in the exploration and production development of petroleum reservoirs. However, there are some limitations in the traditional lithology identification process: (1) It is very time consuming to build a model so that it cannot realize real-time lithology identification during well drilling, (2) it must be modeled by experienced geologists, which consumes a lot of manpower and material resources, and (3) the imbalance of labeled data in well-log data may reduce the classification performance of the model. We have developed a gradient boosting decision tree (GBDT) algorithm combining synthetic minority oversampling technique (SMOTE) to realize fast and automatic lithology identification. First, the raw well-log data are normalized by maximum and minimum normalization algorithm. Then, SMOTE is adopted to balance the number of samples in each class in training process. Next, a lithology identification model is built by GBDT to fit the preprocessed training data set. Finally, the built model is verified with the testing data set. The experimental results indicate that the proposed approach improves the lithology identification performance compared with other machine-learning approaches.
Using a Quitline to Deliver Opt-Out Smoking Cessation for Cancer Patients
Authors: Notier Anna E. , Hager Polly , Brown Karen S. , Petersen Laura , Bedard Louise , Warren Graham W. 
Published: January 2020

PURPOSE: Although smoking by patients with cancer and survivors causes adverse outcomes, many patients with cancer do not receive access to evidence-based tobacco use treatment. The purpose of this article is to report on delivery of tobacco use treatment to patients with cancer using a state-supported Quitline. METHODS: Statewide agencies in Michigan partnered with the Michigan Oncology Quality Consortium to develop and implement a clinical quality improvement initiative with the goal of addressing tobacco use by patients with cancer across Michigan oncology practices. The collaborative designed an opt-out approach for identifying tobacco users and referring them to the Michigan Tobacco Quitline (hereafter known as Quitline) within participating practices. As the initiative progressed, patients with cancer who were not referred through the initiative also became eligible for enrollment in the Quitline program. RESULTS: A total of 4,347 patients with cancer enrolled in the Quitline between 2012 and 2017, and annual referrals from oncology practices increased from 364 (5% of Quitline participants) to 876 (17% of Quitline participants). The 2013-2016 Michigan Behavioral Risk Factor Surveillance System also demonstrated an increase from 60% to 80% of cancer survivors receiving smoking cessation resources. Of 3,892 patients with cancer who had Quitline follow-up data through 2017, 79% completed one or more counseling calls. The 6-month self-reported quit rate for patients with cancer assessed between 2013 and 2016 was 26%. CONCLUSION: Using statewide resources to increase access to evidence-based smoking cessation assistance to patients with cancer is achievable. In an increasingly cost-conscious health care environment, collaborative initiatives that use or enhance existing resources should be considered and refined to deliver effective evidence-based care.
Jewish Citizens of an Imperial Nation-State
Authors: Katz Ethan B. 
Published: January 2020

AbstractThis article draws on the work of recent years on Jews and Algeria to map a French-Algerian frame as a new approach to French Jewish history. The article thinks through the implications of two key ideas from the “new colonial history” for the history of Jews in France and Algeria and posits that Jews in French Algeria can profitably be understood as colonial citizens. After focusing briefly on the French-Algerian War and decolonization, a period for which recent scholarship has developed robustly in suggestive ways, the article turns to a case study from a different era: World War II and the Holocaust. It addresses the history of the majority-Jewish resistance movement in Algiers that paved the way for the success of Operation Torch. Finally, the article considers how this French-Algerian framework might reshape our thinking about certain basic issues in the field of French Jewish history.Cet article s'appuie sur les travaux des dernières années sur les juifs et l'Algérie pour tracer un modèle franco-algérien comme nouvelle approche de l'histoire des juifs en France. L'article examine les implications de deux idées clés de la « nouvelle histoire coloniale » pour l'histoire des juifs en France et en Algérie, et pose comme principe que les juifs de l'Algérie française peuvent à juste titre être compris comme des « citoyens coloniaux ». Cet article commence par aborder brièvement une période que l'historiographie récente a développé de manière suggestive—la guerre franco-algérienne et la décolonisation—avant de passer à l'étude d'une autre époque, la Deuxième Guerre mondiale et l'Holocauste. L'article analyse l'histoire du mouvement de résistance à majorité juive qui a ouvert la voie au succès de l'opération Torch. Enfin, l'article discute de la manière dont ce cadre franco-algérien pourrait modifier notre réflexion sur certaines questions fondamentales pour l'histoire des juifs en France.
Melting Muscles
Authors: Corfman S. Brook 
Published: January 2020

Abstract
This essay considers transmasculine performance artist Cassils's durational piece Tiresias (2010–13) in light of questions around the connections between affect, embodied knowledge, and the capacity of particular forms. Considering the multiple relationships between Cassils and the ice torso that make up Tiresias in its various media, this essay proposes heat as a bodily knowing that is also a specific affective intake, arguing that inquiry into affect should follow the specific pathways of its generation rather than reducing it to a generalized sensation or an always “unexpressed” or “unactualized” potential beyond the scope of particularity. Such a proposal takes an approach both speculative and material to what bodily knowledge might mean for trans studies without reifying a Cartesian dichotomy. In particular, following temperature in Tiresias delimits the tension between the possibility of shifting, in Susan Stryker's words, “the signs of the flesh that discourse fastens upon to situate the body” through the extreme exercise of a body's gestural capabilities and the temporal nature of a body's always shifting form.
Transgender as a Humanitarian Category
Authors: Saleh Fadi 
Published: January 2020

AbstractIn this article, the author foregrounds transgender as a useful category of analysis to shed light on the issue of gender variance and its articulations within the encounter between Syrian queer and gender-variant refugees and the humanitarian-asylum complex. Based on ethnographic fieldwork conducted with Syrian queer and gender-variant refugees in Istanbul in 2014 and 2015, this article contends that transgender as a term first circulates among the queer and gender-variant circles as a thinkable possibility primarily through its function as a humanitarian category, especially as propagated by the United Nations High Commissioner for Refugees (UNHCR). By highlighting this specific encounter, the author attempts to demonstrate, however, that rather than focusing on what the term does to the persons it interpellates, one must map out and document the ways the term is taken up and negotiated by the Syrian queer and gender-variant populations themselves, a method that could help ameliorate the negativity attached to transgender as a Western term and show that other systems of identification and histories of gender variance in the Syrian or Syrian diasporic contexts do not simply disappear or are subsumed by transgender, but are further complicated by it and continue to exist alongside it.
Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells
Authors: Lund Carina , Yellapragada Venkatram , Vuoristo Sanna , Balboa Diego , Trova Sara , Allet Cecile , Eskici Nazli , Pulli Kristiina , Giacobini Paolo , Tuuri Timo , Raivio Taneli 
Published: January 2020

ABSTRACT
Gonadotropin-releasing hormone (GnRH) neurons provide a fundamental signal for the onset of puberty and subsequent reproductive functions by secretion of gonadotropin-releasing hormone. Their disrupted development or function leads to congenital hypogonadotropic hypogonadism (CHH). To model the development of human GnRH neurons, we generated a stable GNRH1-TdTomato reporter cell line in human pluripotent stem cells (hPSCs) using CRISPR-Cas9 genome editing. RNA-sequencing of the reporter clone, differentiated into GnRH neurons by dual SMAD inhibition and FGF8 treatment, revealed 6461 differentially expressed genes between progenitors and GnRH neurons. Expression of the transcription factor ISL1, one of the top 50 most upregulated genes in the TdTomato-expressing GnRH neurons, was confirmed in 10.5 gestational week-old human fetal GnRH neurons. Among the differentially expressed genes, we detected 15 genes that are implicated in CHH and several genes that are implicated in human puberty timing. Finally, FGF8 treatment in the neuronal progenitor pool led to upregulation of 37 genes expressed both in progenitors and in TdTomato-expressing GnRH neurons, which suggests upstream regulation of these genes by FGF8 signaling during GnRH neuron differentiation. These results illustrate how hPSC-derived human GnRH neuron transcriptomic analysis can be utilized to dissect signaling pathways and gene regulatory networks involved in human GnRH neuron development.
This article has an associated First Person interview with the first author of the paper.
Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1
Authors: Rodriguez-Gil Jorge L. , Watkins-Chow Dawn E. , Baxter Laura L. , Elliot Gene , Harper Ursula L. , Wincovitch Stephen M. , Wedel Julia C. , Incao Arturo A. , Huebecker Mylene , Boehm Frederick J. , Garver William S. , Porter Forbes D. , Broman Karl W. , Platt Frances M. , Pavan William J. 
Published: January 2020

ABSTRACT
Niemann-Pick disease type C1 (NPC1) is a rare, fatal neurodegenerative disorder characterized by lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological degeneration and premature death. NPC1 is extremely heterogeneous in the timing of clinical presentation and is associated with a wide spectrum of causative NPC1 mutations. To study the genetic architecture of NPC1, we have generated a new NPC1 mouse model, Npc1em1Pav. Npc1em1Pav/em1Pav mutants showed notably reduced NPC1 protein compared to controls and displayed the pathological and biochemical hallmarks of NPC1. Interestingly, Npc1em1Pav/em1Pav mutants on a C57BL/6J genetic background showed more severe visceral pathology and a significantly shorter lifespan compared to Npc1em1Pav/em1Pav mutants on a BALB/cJ background, suggesting that strain-specific modifiers contribute to disease severity and survival. QTL analysis for lifespan of 202 backcross N2 mutants on a mixed C57BL/6J and BALB/cJ background detected significant linkage to markers on chromosomes 1 and 7. The discovery of these modifier regions demonstrates that mouse models are powerful tools for analyzing the genetics underlying rare human diseases, which can be used to improve understanding of the variability in NPC1 phenotypes and advance options for patient diagnosis and therapy.
This article has an associated First Person interview with the first author of the paper.
YAP/TAZ functions and their regulation at a glance
Authors: Pocaterra Arianna , Romani Patrizia , Dupont Sirio 
Published: January 2020

ABSTRACT
YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs, including the Hippo pathway. In the nucleus, they pair with DNA-binding factors of the TEAD family to regulate gene expression. Nuclear YAP/TAZ promote cell proliferation, organ overgrowth, survival to stress and dedifferentiation of post-mitotic cells into their respective tissue progenitors. YAP/TAZ are required for growth of embryonic tissues, wound healing and organ regeneration, where they are activated by cell-intrinsic and extrinsic cues. Surprisingly, this activity is dispensable in many adult self-renewing tissues, where YAP/TAZ are constantly kept in check. YAP/TAZ lay at the center of a complex regulatory network including cell-autonomous factors but also cell- and tissue-level structural features such as the mechanical properties of the cell microenvironment, the establishment of cell–cell junctions and of basolateral tissue polarity. Enhanced levels and activity of YAP/TAZ are observed in many cancers, where they sustain tumor growth, drug resistance and malignancy. In this Cell Science at a Glance article and the accompanying poster, we review the biological functions of YAP/TAZ and their regulatory mechanisms, and highlight their position at the center of a complex signaling network.
Measures of family planning service quality associated with contraceptive discontinuation: an analysis of Measurement, Learning & Evaluation (MLE) project data from urban Kenya
Authors: Feeser Karla , Chakraborty Nirali M. , Calhoun Lisa , Speizer Ilene S. 
Published: January 2020

Introduction: Several measures to assess family planning service quality (FPQ) exist, yet there is limited evidence on their association with contraceptive discontinuation. Using data from the Measurement, Learning & Evaluation (MLE) Project, this study investigates the association between FPQ and discontinuation-while-in-need without switching in five cities in Kenya. Two measures of FPQ are examined – the Method Information Index (MII) and a comprehensive service delivery point (SDP) assessment rooted in the Bruce Framework for FPQ. Methods: Three models were constructed: two to assess MII reported in household interviews (as an ordinal and binary variable) among 1,033 FP users, and one for facility-level quality domains among 938 FP users who could be linked to a facility type included in the SDP assessment. Cox proportional hazards ratios were estimated where the event of interest was discontinuation-while-in-need without switching. Facility-level FPQ domains were identified using exploratory factor analysis (EFA) using SDP assessment data from 124 facilities. Results: A woman’s likelihood of discontinuation-while-in-need was approximately halved whether she was informed of one aspect of MII (HR: 0.45, p < 0.05), or all three (HR: 0.51, p < 0.01) versus receiving no information, when MII was assessed as an ordinal variable. Six facility-level quality domains were identified in EFA. Higher scores in information exchange, privacy, autonomy & dignity and technical competence were associated with a reduced risk of discontinuation-while-in-need (p < 0.05). Conclusions: The MII has potential as an actionable metric for FPQ monitoring at the health facility level. Furthermore, family planning facilities and programs should emphasize information provision and client-centered approaches to care alongside technical competence in the provision of FP care.
Dynamic Assortment Optimization for Reusable Products with Random Usage Durations
Authors: Rusmevichientong Paat , Sumida Mika , Topaloglu Huseyin 
Published: January 2020

We consider dynamic assortment problems with reusable products, in which each arriving customer chooses a product within an offered assortment, uses the product for a random duration of time, and returns the product back to the firm to be used by other customers. The goal is to find a policy for deciding on the assortment to offer to each customer so that the total expected revenue over a finite selling horizon is maximized. The dynamic-programming formulation of this problem requires a high-dimensional state variable that keeps track of the on-hand product inventories, as well as the products that are currently in use. We present a tractable approach to compute a policy that is guaranteed to obtain at least 50% of the optimal total expected revenue. This policy is based on constructing linear approximations to the optimal value functions. When the usage duration is infinite or follows a negative binomial distribution, we also show how to efficiently perform rollout on a simple static policy. Performing rollout corresponds to using separable and nonlinear value function approximations. The resulting policy is also guaranteed to obtain at least 50% of the optimal total expected revenue. The special case of our model with infinite usage durations captures the case where the customers purchase the products outright without returning them at all. Under infinite usage durations, we give a variant of our rollout approach whose total expected revenue differs from the optimal by a factor that approaches 1 with rate cubic-root of Cmin, where Cmin is the smallest inventory of a product. We provide computational experiments based on simulated data for dynamic assortment management, as well as real parking transaction data for the city of Seattle. Our computational experiments demonstrate that the practical performance of our policies is substantially better than their performance guarantees and that performing rollout yields noticeable improvements.This paper was accepted by Yinyu Ye, optimization.
How Fast Should Trades Settle?
Authors: Khapko Mariana , Zoican Marius 
Published: January 2020

Recent regulatory and industry initiatives aim to streamline post-trade infrastructures. Does faster settlement benefit markets? We build a model of intermediated trading with imperfectly competitive securities lending. Faster settlement benefits impatient traders but increases borrowing needs. We find that flexible failure-to-deliver penalties reduce this tension, disciplining security lender competition and allowing for real-time settlement. Optimal penalties resemble put options on the lending market: they protect traders against high settlement costs but do not eliminate failures to deliver. Mandating automatic security borrowing to prevent failures to deliver triggers a toxic settlement rat race to lock in low borrowing costs. This paper was accepted by Gustavo Manso, finance.
Low-loss and broadband fiber-to-chip coupler by 3D fabrication on a silicon photonic platform
Authors: Luo Haozhi , Xie Fei , Cao Yaoyu , Yu Siyuan , Chen Lifeng , Cai Xinlun 
Published: January 2020

We propose and demonstrate a low-loss fiber-to-chip vertical coupler on the silicon photonic platform by using a 3D two-photon fabrication method. Such a coupler significantly reduces insertion loss, measured to be 1 dB, and provides a wide working wavelength range for both TE and TM polarizations over the entire C-band. Moreover, a large tolerance for misalignment of the coupling fiber, up to 4.5 µm for a 1 dB loss, enables the development of relaxed alignment techniques.
KONTRIBUSI AUDIT INTERNAL TERHADAP MANAGEMEN RISIKO
Authors: Hadinata Sofyan 
Published: January 2020

AbstractRisks always exist in a business activity of an organization. Risks are closely related to the differences between the results and the expectations. Risk management focuses on the anticipatory actions by recognizing potential risks and influences. Risk management is part of the entity’s internal control in which the main responsibility is in the hand of the company manager or the entity. Internal auditor as the employee or the internal party has the duty to implement the risk management. Internal auditor conducts an audit process towards internal control and gives assurance in the process of risk management. The internal auditor who takes part in consultation role can assist the organization in identifying, evaluating, and implementing relevant risk management and risk control methodologies. Risk management procedures are identifying risks, constructing plans, and determining solutions. Some of the solutions are avoiding, minimizing, removing, or accepting the risks. Keywords: risk, anticipatory, internal controlAbstrakRisiko melekat pada suatu aktivitas bisnis organisasi. Risiko terkait erat antara ketidaksesuaian hasil dengan yang diharapkan. Managemen risiko merupakan suatu tindakan untuk mengurangi ketidakpastian yang berfokus pada tindakan antisipasi/pencegahan, dengan cara mengidentifikasi risiko yang mungkin terjadi sekaligus dampak yang mungkin ditimbulkan. Managemen risiko merupakan bagian dari pengendalian internal entitas yang tanggung jawab utamanya di tangan manager perusahaan atau entitas. Auditor internal selaku pegawai atau pihak internal perusahaan juga memiliki tugas atau kewajiban atas pelaksanaan managemen risiko. Audit internal melakukan proses audit terhadap pengendalian internal dan memberikan keyakinan terhadap proses managemen risiko. Auditor internal memiliki peran konsultasi yang dapat membantu organisasi dalam mengidentifikasi, mengevaluasi, dan menerapkan metodologi managemen risiko dan pengendalian yang relevan. Langkah-langkah yang harus dilakukan dalam managemen risiko adalah identifikasi risiko, membuat perencanaan, dan menentukan cara penanganannya. Penangannya risiko dapat dilakukan dengan cara yaitu menghindari, mengurangi, memindahkan, atau menerima risiko tersebut.Kata kunci: risiko, antisipasi/pencegahan, pengendalian internal
El karst de Yucatán: su origen, morfología y biología
Authors: Estrada Medina Hector , Jiménez Osornio Juan José , Álvarez-Rivera Oscar , Barrientos Medina Roberto Carlos 
Published: January 2020

El karst del estado de Yucatán, México, tiene su origen en los arrecifes coralinos y sedimentos marinos que, al exponerse a la superficie, formaron la roca caliza. Los procesos de solubilización-precipitación de esta roca han promovido la ausencia de corrientes de agua superficiales, un relieve ligeramente ondulado con planicies, depresiones y montículos, afloramientos y presencia de cenotes. Los diferentes grados de porosidad y dureza de la roca han permitido la formación desde pequeñas oquedades y acumulaciones de suelo, hasta complejos sistemas de cuevas secas y húmedas. El manejo de este tipo de áreas debe partir del conocimiento de su origen, morfología y biología para garantizar el uso sustentable de los recursos naturales. Se requiere especial atención en el manejo de la extracción de roca caliza, las actividades turísticas y productivas relacionadas con el uso de agua del acuífero, así como el volumen y calidad de las descargas de aguas residuales al suelo, cenotes y el mar.
Sejarah Peranan Perempuan dalam Hijrah Rasulullah SAW pada 622 M
Authors: Rubiyanah Rubiyanah 
Published: January 2020

This article discusses the period of Rasulullah saw hijriah which is an important moment in the history of Islam. The word hijriah means physically move to another place. Rasulullah saw and his companions moved from Mekkah to Yastrib which in 622 became Madinah. After the decease of Rasulullah, the context of hijrah changed; first, leaving a place full of kafir to a place full of Muslim, like the hijrah of Rasulullah saw from MEkkah to Madinah. Second, leaving bad behavior and sins to virtue Allah commands as explained in al-Qur'an; He said; " I will leave home for the sake of my LOrd" (Q.S 29;26). History notes the success of Rasulullah and his companions' hijrah was the result of good cooperation between generations; older generation (Ali ibn Abu Thali), and women (Asma binti Abu Bakar, Ummu Ma'nan, Shafiyah binti Abul Muthalib, etc.)