bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function
Authors: Taylor Guy S. , Smith Kieran , Capper Tess E. , Scragg Jadine H. , Bashir Ayat , Flatt Anneliese , Stevenson Emma J. , McDonald Timothy J. , Oram Richard A. , Shaw James A. , West Daniel J. 
Published: August 2020

OBJECTIVE
To investigate the impact of residual β-cell function on continuous glucose monitoring (CGM) outcomes following acute exercise in people with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Thirty participants with T1D for ≥3 years were recruited. First, participants wore a blinded CGM unit for 7 days of free-living data capture. Second, a 3-h mixed-meal test assessed stimulated C-peptide and glucagon. Peak C-peptide was used to allocate participants into undetectable (Cpepund &lt;3 pmol/L), low (Cpeplow 3–200 pmol/L), or high (Cpephigh &gt;200 pmol/L) C-peptide groups. Finally, participants completed 45 min of incline treadmill walking at 60% VO2peak followed by a further 48-h CGM capture.

RESULTS
CGM parameters were comparable across groups during the free-living observation week. In the 12- and 24-h postexercise periods (12 h and 24 h), the Cpephigh group had a significantly greater amount of time spent with glucose 3.9–10 mmol/L (12 h, 73.5 ± 27.6%; 24 h, 76.3 ± 19.2%) compared with Cpeplow (12 h, 43.6 ± 26.1%, P = 0.027; 24 h, 52.3 ± 25.0%, P = 0.067) or Cpepund (12 h, 40.6 ± 17.0%, P = 0.010; 24 h, 51.3 ± 22.3%, P = 0.041). Time spent in hyperglycemia (12 h and 24 h glucose &gt;10 and &gt;13.9 mmol/L, P &lt; 0.05) and glycemic variability (12 h and 24 h SD, P &lt; 0.01) were significantly lower in the Cpephigh group compared with Cpepund and Cpeplow. Change in CGM outcomes from pre-exercise to 24-h postexercise was divergent: Cpepund and Cpeplow experienced worsening (glucose 3.9–10 mmol/L: −9.1% and −16.2%, respectively), with Cpephigh experiencing improvement (+12.1%) (P = 0.017).

CONCLUSIONS
Residual β-cell function may partially explain the interindividual variation in the acute glycemic benefits of exercise in individuals with T1D. Quantifying C-peptide could aid in providing personalized and targeted support for exercising patients.
PENGARUH VARIETAS DAN JARAK TANAM YANG BERBEDA TERHADAP KANDUNGAN NUTRIEN HIJAUAN JAGUNG
Authors: Farda Fitria Tsani , Wijaya Agung Kusuma , Liman Liman , Muhtarudin Muhtarudin , Putri Deviana , Hasanah Miftahul 
Published: August 2020

Penelitian bertujuan untuk mengetahui pengaruh varietas dan jarak tanam yang berbeda terhadap kandungan nutrisi hijauan jagung. Penelitian dilakukan pada bulan Desember 2018 hingga Juni 2019 di Laboratorium Lapang Terpadu dan Laboratorium Nutrisi dan Makanan Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung. Perlakuan dilakukan secara eksperimental menggunakan Rancangan Acak Kelompok Faktorial. Faktor pertama adalah varietas jagung (A = Bisi-18, B = NK 212, C = Pioneer 36) dan faktor ke dua jarak tanam jagung (J1= 60x20 cm, J2=80x20 cm). Tahapan penelitian mencakup tujuh tahap yaitu tahap pembuatan kompos kotoran sapi, persiapan lahan dan penanaman, pemupukan, pemeliharaan hijauan, panen dan pascapanen, pengambilan sampel, serta tahap analisis proksimat. Setiap perlakuan dikelompokkan berdasarkan ketinggian lahan menjadi kelompok 1, kelompok 2 dan kelompok 3. Peubah yang diamati adalah kandungan nutrisi bahan organik, protein kasar, lemak kasar, serat kasar dan Total Digestible Nutrient hijauan jagung. Hasil penelitian menunjukkan tidak terdapat interaksi antara perlakuan varietas dan jarak tanam. Perlakuan varietas serta jarak tanam tidak berpengaruh nyata terhadap kadar protein kasar, lemak kasar dan serat kasar hijauan jagung. Kata kunci : Analisis proksimat, Hijauan jagung, Jarak tanam, Kandungan nutrisi, Varietas jagung.
KLASTERISASI CLV DENGAN MODEL LRFM MENGGUNAKAN ALGORITMA FUZZY C-MEANS (Studi Kasus: Pangeran Gym Pekanbaru)
Authors: Ditendra Eghi , Monalisa Siti , Anderjovi Stedico , Lesmana Surya 
Published: August 2020

Kepuasan pelanggan merupakan faktor yang sangat penting bagi setiap perusahaan maka dari itu Perusahaan perlu mempelajari perilaku konsumen yang bertujuan untuk mengetahui dan memahami berbagai aspek yang ada pada konsumen.Penelitian ini bertujuan untuk menghasilkan nilai Customer Lifetime Value (CLV) setiap segmen pelanggan pada Pangeran Gym Pekanbaru dan menentukan segmentasi pelanggan berdasarkan jenis kelamin serta umur dengan menggunakan algoritma fuzzy c-means. Klasterisasi pelanggan menggunakan model Length Recency Frequency Monetary (LRFM) dan pembentukan kluster dibagi atas 3 kluster.Nilai CLV akan dihasilkan dengan mengalikan nilai normalisasi LRFM dengan nilai bobot LRFM dan selanjutnya dijumlahkan.Penjumlahan CLV dilakukan pada masing-masing kluster yang telah terbentuk.Hasil dari penjumlahan tersebut maka dicari hasil rangking CLV. Rangking CLV tertinggi dihasilkan dari nilai CLV terbsesar diantara 3 kluster tersebut. Rangking CLV tertinggi pada penelitian ini adalah kluster pertama yaitu dengan nilai CLV 0,504 dengan simbol LRFM L↑R↑F↑M↑ dengan arti bahwa kluster ini memiliki segmen pelanggan dengan nilai loyalitas yang tinggi. Ranking CLV ke 2 adalah kluster ketiga dengan nilai CLV 0,341 dan selanjutnya kluster kedua dengan nilai CLV 0,225. Dari 100 data transaksi pada Pangeran Gym Pekanbaru terdapat 83 transaksi oleh jenis kelamin laki-laki dan 17 transaksi dilakukan oleh jenis kelamin perempuan. Kemudian dari 100 data transaksi pada Pangeran Gym Pekanbaru terdapat 82 transaksi dilakukan oleh remaja umur 12 – 25 tahun dan 18 transaksi dilakukan oleh dewasa umur 26 – 45 tahun.
Estratégias didáticas na educação digital MOOC RRI
Authors: Santos Katia Ethiénne Esteves dos , Torres Patrícia Lupion , Chery Pierre Narcisse 
Published: August 2020

As transformações acontecem de forma vertiginosa nos últimos anos em nossa sociedade, impulsionando os diferentes processos e as relações entre grupos sociais. A educação digital possibilita o acesso à informação e ao conhecimento em diferentes espaços, contextos e temporalidades, tanto em ambientes formais de educação quanto não formais, na perspectiva da aprendizagem on-life. Este cenário passa a demandar a necessidade de que as pessoas estejam formadas para a gestão do conhecimento que envolve a aprendizagem ao longo da vida, o ser autônomo, o saber, o pesquisar, o refletir, o analisar e criar soluções possíveis. Na perspectiva de mudança nas propostas didático-pedagógicas-tecnológicas verifica-se a premissa de utilizar estratégias didáticas diferenciadas. Para esta reflexão, os autores Santos (2018), Okada (2016), Torres (2017) e Kowalski (2018) entre outros dão sustentação para a discussão referente a valorização efetiva dos estudantes na construção do conhecimento e no desenvolvimento de investigadores, com foco na proposta de Pesquisa e Inovação Responsáveis (Responsible Research and Innovation - RRI) oportunizando a estes pesquisar, refletir, experimentar e criar, partindo de situações-problema reais. Este artigo resulta de uma investigação realizada com um grupo de estudos do mestrado e doutorado em Educação e propõe-se a refletir sobre o processo de construção de um curso a distância (MOOC) para a formação de professores na utilização da proposta de RRI. O curso busca valorizar a pesquisa e a inovação, estruturado em cinco módulos que envolvem uma ambientação inicial e as habilidades de investigação científica por meio do adotar, do adaptar, do transformar e do aplicar.
Field assessment of corn yield losses and compensatory yield for infested plants by Lepidopteran stem borers in different sowing dates at El-Behiera governorate, Egypt.
Authors: Al-Eryan M. A. S  , Abu- Shall Amany M. H.  , Ibrahiem H. K.  , Huessein Hanaa S.  
Published: August 2020

Whenever the determination of yield loss and economic injury levels are essential tools for initiating integrated pest management (IPM) programs in the maize field, the assessment of compensatory yield is very important for determinate the accurate losses in the field and the recovery power for the maize verity. The present study aimed to estimate the yield losses of three maize varieties due to Sesamia critica and Ostrinia nubilalis, infestation; regression between maize yield losses and percent of infestation and determine the compensatory yield arising in intact plants as a result of absence or dead (caused by infestation) of adjacent plants under field conditions in El-Behiera governorate. The present results showed that yield losses resulting from S. cretica infestation in early sowed maize ranged from 5.29 – 32.17%. In case of maize that sowed in recommended date “June”, yield losses due to S. cretica was slightly decreased, and it accompanied with O. nubilalis infestation in two fields, which increased the total yield losses. A simple linear regression turned out between the percentage of infestation of S. cretica or O. nubilalis and percentage of yield losses, with R2 values 0.84 and 0.45, respectively. The yellow corn was more tolerant to stem borers infestation than white corn with percentages of increase rate in compensatory yield 27.07 %.
Whenever the determination of yield loss and economic injury levels are essential tools for initiating integrated pest management (IPM) programs in the maize field, the assessment of compensatory yield is very important for determinate the accurate losses in the field and the recovery power for the maize verity. The present study aimed to estimate the yield losses of three maize varieties due to Sesamia critica and Ostrinia nubilalis, infestation; regression between maize yield losses and percent of infestation and determine the compensatory yield arising in intact plants as a result of absence or dead (caused by infestation) of adjacent plants under field conditions in El-Behiera governorate. The present results showed that yield losses resulting from S. cretica infestation in early sowed maize ranged from 5.29 – 32.17%. In case of maize that sowed in recommended date “June”, yield losses due to S. cretica was slightly decreased, and it accompanied with O. nubilalis infestation in two fields, which increased the total yield losses. A simple linear regression turned out between the percentage of infestation of S. cretica or O. nubilalis and percentage of yield losses, with R2 values 0.84 and 0.45, respectively. The yellow corn was more tolerant to stem borers infestation than white corn with percentages of increase rate in compensatory yield 27.07 %.
Impact of Pharmacist-Led Cognitive Behavioural Therapy for Chronic Insomnia
Authors: Nurkowski Joshua , Elshorbagy Habiba , Halpape Katelyn , Jensen Karen , Lamb Darcy , Landry Eric , Remillard Alfred , Jorgenson Derek 
Published: August 2020

Background: Chronic insomnia is a common medical condition that negatively impacts quality of life and daytime function. Access to the first-line treatment for insomnia, cognitive behavioural therapy (CBT-i), is limited. Pharmacists are well positioned to provide this service, but evidence regarding pharmacist delivered CBT-i is sparse. The aim of this study was to evaluate the effectiveness of CBT-i delivered by pharmacists practicing in an outpatient clinic setting.
Methods: This study was a retrospective chart audit of adult patients with chronic insomnia who received CBT-i from a pharmacist at one of two outpatient clinics in Canada. The primary endpoints were the differences between patient self-reported sleep diary parameters and utilization of hypnotic medications before and after CBT-i was delivered. The differences in patient reported sleep parameters were compared using Wilcoxon Signed Rank test and paired samples t-test and changes in hypnotic utilization was compared using McNemar Chi-square test.
Results: 183 patients were referred for CBT-i and attended an initial appointment with a pharmacist. Of these, 105 did not receive the CBT-i. This resulted in 78 patients who met the inclusion criteria. Changes in sleep diary parameters were all statistically significantly improved after patients received CBT-i, except for total sleep time. Hypnotic medication use was also reduced. At baseline, 71.8% (n=56/78) of patients were taking one or more hypnotic medications compared to 52.6% (n=41/78) after CBT-i (p=0.0003).
Discussion: The results of this study provide preliminary evidence that pharmacists working in an outpatient clinic setting may be able to effectively deliver CBT-i for patients with chronic insomnia. The external validity of these results is limited by the observational study design and the inclusion of pharmacists practicing in outpatient clinics, which is not the setting where most pharmacists currently practice.
Conclusion: This observational study found improvements in sleep quality and efficiency, as well as, a reduction in hypnotic medication use, in patients who received CBT-i from pharmacists practicing in an outpatient clinic setting. Future randomized, controlled trials should evaluate the impact of CBT-i in a larger sample of patients, provided by pharmacists practicing in both outpatient clinics and community pharmacies.

Original Research
Risk of infection and disease progression in children exposed to tuberculosis at home, Colombia
Authors: Benjumea Bedoya Dione , Marín Diana M , Robledo Jaime , Barrera Luis F , López Lucelly , Del Corral Helena , Ferro Beatriz E , Villegas Sonia L , Díaz María Lilia , Rojas Carlos A , García Luis F , Arbeláez María P 
Published: August 2020

Aim: To assess the risk of tuberculosis (infection and disease) in children less than 15 years’ old who are household contacts of pulmonary tuberculosis patients in three Colombian cities (Medellín, Cali, and Popayán).

Methods: A cohort of 1,040 children household contacts of 380 adults with smear-positive pulmonary tuberculosis was followed up for 24 months. Study period 2005-2009.

Results: Tuberculin skin test was positive (≥10 mm) in 43.7% (95% CI: 39.2-48.2). Tuberculin skin test positivity was associated with age 10-14 years (Prevalence Ratio -PR= 1.43, 95% CI: 1.1-1.9), having a BCG vaccine scar (PR= 1.52, 95% CI: 1.1-2.1), underweight, closer proximity to the index case and exposure time >3 months. The annual risk of infection (tuberculin skin test induration increase of 6 mm or more per year) was 17% (95% CI: 11.8-22.2) and was associated with a bacillary load of the adult index case (Relative Risk -RR= 2.12, 95% CI: 1.0-4.3). The incidence rate of active tuberculosis was 12.4 cases per 1,000 persons-year. Children <5 years without BCG vaccine scar had a greater risk of developing active disease (Hazard Ratio -HR= 6.00, 95% CI: 1.3-28.3) than those with scar (HR= 1.33, 95% CI: 0.5-3.4). The risk of developing active tuberculosis augmented along with the increase from initial tuberculin skin test (tuberculin skin test 5-9 mm HR= 8.55, 95% CI: 2.5-29.2; tuberculin skin test ≥10 mm HR= 8.16, 95% CI: 2.0-32.9).

Conclusions: There is a need for prompt interruption of adult-to-children tuberculosis transmission within households. Conducting proper contact investigation and offering chemoprophylaxis to infected children could reduce tuberculosis transmission.
Trends in cancer incidence in Uruguay:2002 - 2015
Authors: Garau Mariela , Musetti Carina , Alonso Rafael , Barrios Enrique 
Published: August 2020

Background: Uruguay is the southamerican country which has the highest cancer incidence and mortality rates. The National Cancer Registry collects data on cancer cases nationwide since 1989 and has reached high quality standards in the last decades. This is the first report on incidence trends.
Methods: Data from the National Cancer Registry of all new cases of invasive cancer from twelve sites diagnosed in 2002-2015 was analyzed. Age-standardized rates were calculated. Trends of incidence rates were analyzed using joinpoint regression models.
Results For both, men and women, incidence rates trends for all cancer sites, colo-rectal and bladder cancer remained stable. Esophageal and gastric cancers descend while Thyroid and kidney cancer incidence increased. In men lung cancer decreased; testicular cancer increased, and prostate cancer increased at the beginning of the period and decreased in the final years. In women; lung cancer increased, breast cancer remained stable and cervical cancer presented a significant decline from 2005 to 2010 and reached a plateau since then.
Conclusion: Cancer incidence dynamics are complex and affected not only by Public Health policies such as tobacco control, vaccination and screening programs, but also by environmental and life style changes and the attitude of the medical community towards the application of diagnostic and therapeutic tools. The aim of this paper is to analyze cancer incidence time trends in the country and provide possible explanations to them.
Šķērssubsidēšanas pieļaujamība FKTK finansēšanas modelī
Authors: Grasis Jānis 
Published: August 2020

Rakstā ir analizēts Latvijas Republikas Satversmes tiesas spriedums lietā Nr. 2019-09-03, kuras izskatīšanā piedalījos kā pieaicinātā persona. AS “PNB Banka” iesniedza konstitucionālās sūdzības pieteikumu par Finanšu un kapitāla tirgus komisijas (FKTK) normatīvo noteikumu Nr. 198 “Finanšu un kapitāla tirgus dalībnieku maksājumu apmēra Finanšu un kapitāla tirgus komisijas finansēšanai 2019. gadā noteikšanas un pārskatu iesniegšanas normatīvie noteikumi” 2.11. punkta neatbilstību Latvijas Republikas Satversmes 1. pantam, 89. pantam un 91. panta pirmajam teikumam [3]. Satversmes tiesa atzina, ka apstrīdētā norma neatbilst Satversmes 91. panta pirmajam teikumam, jo apstrīdētajā normā paredzētā atšķirīgā attieksme nav noteikta saskaņā ar normatīvajos aktos paredzētā kārtībā pieņemtu tiesību normu. ﻿﻿Šī raksta autors sniedza Satversmes tiesai arī savus apsvērumus šīs konstitucionālās sūdzības sakarā.

﻿The article analyses the judgment of the Constitutional Court of the Republic of Latvia in case 2019-09-03, in which the author of the article participated as the guest person. The application for a constitutional complaint was submitted by AS “PNB Bank” regarding the non-compliance of Section 2.11 of the Regulation No 198 of the Financial and Capital Market Commission for the financing of the Financial and Capital Market Commission in 2019 with Article 1, Article 89 and with the first sentence of Article 91 of the Constitution of the Republic of Latvia. The Constitutional Court acknowledged that, since the contested rule does not prescribe a different treatment according to a rule of law adopted in accordance with the procedures provided for by regulatory enactments, it was recognised that the contested rule does not comply with the first sentence of Article 91 of the Constitution. The author also provided the Constitutional Court with his observations on this constitutional complaint.
Personas elektroniskās identifikācijas tiesiskā regulējuma problemātika
Authors: Mote Dace 
Published: August 2020

Attīstoties informācijas tehnoloģijām un digitālajiem risinājumiem, pieaug iedzīvotāju vēlme saņemt pakalpojumus elektroniski – vai tie būtu sadzīviska rakstura pakalpojumi vai valsts un pašvaldības iestāžu piedāvātie elektroniskie pakalpojumi. Lai persona varētu saņemt attālinātus iestāžu pakalpojumus, tai ir nepieciešams elektroniski identificēties. Personas veiksmīgas elektroniskās identifikācijas būtiskākās komponentes ir abu pušu saistību izpilde personas datu drošības jautājumos un pakalpojumu sniedzēja spēja tehniski nodrošināt personas elektronisko identifikāciju. ﻿﻿Rakstā tiek apskatīti elektroniskās identifikācijas veidi, to raksturojums un tiesiskie aspekti, izvērtējot tiesisko regulējumu, pieejamo literatūru un aktuālo tiesu praksi elektroniskās identificēšanas jautājumos. Raksts ir balstīts uz autores izstrādāto maģistra darbu, kurā tika pētīti personas elektroniskās identifikācijas riski un tiesiskā regulējuma problemātika.

﻿﻿With the development of information technologies and digital solutions, desire of people to receive services electronically increases – whether it is a domestic or an electronic service offered by state or municipal authorities. In order to receive services of authorities remotely, a person needs to be identified electronically. The most important components of a person’s successful electronic identification are the fulfillment of both parties’ obligations on personal data security issues and the ability of the service provider to technically secure the person’s electronic identification. The Author of the paper has analysed types of person’s electronic identification, their characterisation and legal aspects, evaluating legal regulation, available literature and current court practice in electronic identification issues. The article is based on the author’s Master’s thesis, which explored the risks of electronic identification of a person and the issues of legal regulation.
Fathers’ Experiences after their Exposure to a Fatherhood Intervention Programme
Authors: Erasmus Charlene , Carelse Shernaaz , Payne Jessica 
Published: August 2020

Fatherhood intervention programmes seek to redress fundamental issues that prevent men from succeeding in their fathering role. An understanding and evidence of the influence of fatherhood interventions on the role of the father in the family are thus required. This study, conducted in South Africa, explored the perceptions and experiences of fathers and their partners after the fathers’ exposure to a fatherhood intervention programme. A qualitative approach with semi-structured interviews was utilised to this end. A thematic analysis was used to analyse the data and three main themes emerged from the analysis. The study found that fathers and their partners perceived and experienced the fathers to be more involved, responsible, and sharing in parenthood after exposure to the fatherhood intervention programme. This led to an increase of father involvement with children – childcare activities, schoolwork, the well-being of the children, and an increase in involvement in the home.
The health status of children who had cardiac surgery in the first 3 months of life due to coarctation of the aorta
Authors:   Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia, Delyagin Vasiliy M. 
Published: August 2020

Актуальность. Врожденные пороки сердца (ВПС) как причина инвалидности находятся на 2-м месте после поражения центральной нервной си-стемы. Возможности современной медицины значительно увеличили показатель выживаемости таких детей. Значительная часть новорожденных с ВПС доживает до взрослого возраста. Стоит задача обеспечения таким людям максимально возможного качества жизни, что неосуществимо без интегральных исследований состояния здоровья в отдаленном послеоперационном периоде. Материалы и методы. Наблюдали 12 детей (6 девочек и 6 мальчиков), оперированных по поводу коарктации аорты. Длительность наблюдения 1–9 лет (Ме – 5,5). Результаты. Коарктация аорты сочеталась с другими пороками (11/12): аномалии клапана аорты с умеренным нарушением гемодинамики (4/12), дефекты перегородок сердца (5/12), открытый артериальный проток (4/12). Зарегистрировано сочетание пороков. В отдаленном периоде выявля-лись неусидчивость, сложности в усвоении школьной программы, нарушения сна, невротические реакции, микроаденома гипофиза, железодефи-цитная анемия, инфантильная анорексия. Часто отмечались аллергические реакции, боли в животе, запоры, гастроэзофагеальный рефлюкс, на-рушения осанки, аномалии прикуса и роста зубов, грыжи, деформации стоп. Заключение. ВПС не изолированный дефект структуры сердца, а страдание всех тканей и структур сердца (поэтому правомочен термин «хрони-ческая болезнь сердца»). Но одновременно страдают и другие системы организма в результате нарушения кровообращения и сопутствующих со-стояний. Даются рекомендации по совершенствованию помощи детям с ВПС. Ключевые слова: дети, аорта, коарктация, отдаленные исходы. Для цитирования: Делягин В.М. Состояние здоровья детей, перенесших кардиохирургическое вмешательство в первые 3 мес жизни по поводу коарктации аорты. Педиатрия. Consilium Medicum. 2020; 1: 48–51. DOI: 10.26442/26586630.2020.1.200002