bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Where Art Thou?’: Ethnocracy, Toponymic Silence, and Toponymic Subjugation in the Harare Commemorative Landscapes During the Mugabe Era (1980–2017)
Authors: Mamvura Zvinashe 
Published: August 2020

AbstractThis article explores the post-colonial national identity formation using place names that commemorate the nation’s past in Zimbabwe. Place name alterations that the new political elites implemented at independence in 1980 were aimed at disassembling relics of the deposed regime and craft a new national identity. The commemorative landscapes of Harare, as a national capital, constitute a strategic medium in the constitution of national identity. Ethnicity dominated the political landscape in Zimbabwe. The two main political parties, the Zimbabwe African National Union (ZANU) and Zimbabwe African People’s Union (ZAPU), have been aligned with the two supertribes, Shona and Ndebele, respectively. The article explores how the ruling ZANU (PF) government whose leadership was largely Shona used a meta-narrative modelled around discourses of exclusionary autochthony and a partial presentation of the liberation war history that projected ZAPU as having made an insignificant contribution to the liberation war to construct a national identity. It concludes that the use of exclusionary definitions of belonging and a one-sided presentation of the war past that projected ZANU as having contributed more to the liberation war entrenched Shona ethnic chauvinistic tendencies and propagated ZANU (PF) political hegemony. Using the theoretical lens of critical toponymy, the article argues that politically motivated place renaming efforts usually select from the past aspects that serve present political purposes.
Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype
Authors: Liao Yiteng , Li Hao , Cao Hao , Dong Yun , Gao Lei , Liu Zhongmin , Ge Junbo , Zhu Hongming 
Published: August 2020

AbstractFibrotic remodeling is an adverse consequence of immune response-driven phenotypic modulation of cardiac cells following myocardial infarction (MI). MicroRNA-146b (miR-146b) is an active regulator of immunomodulation, but its function in the cardiac inflammatory cascade and its clinical implication in fibrotic remodeling following MI remain largely unknown. Herein, miR-146b-5p was found to be upregulated in the infarcted myocardium of mice and the serum of myocardial ischemia patients. Gain- and loss-of-function experiments demonstrated that miR-146b-5p was a hypoxia-induced regulator that governed the pro-fibrotic phenotype transition of cardiac cells. Overexpression of miR-146b-5p activated fibroblast proliferation, migration, and fibroblast-to-myofibroblast transition, impaired endothelial cell function and stress survival, and disturbed macrophage paracrine signaling. Interestingly, the opposite effects were observed when miR-146b-5p expression was inhibited. Luciferase assays and rescue studies demonstrated that the miR-146b-5p target genes mediating the above phenotypic modulations included interleukin 1 receptor associated kinase 1 (IRAK1) and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1). Local delivery of a miR-146b-5p antagomir significantly reduced fibrosis and cell death, and upregulated capillary and reparative macrophages in the infarcted myocardium to restore cardiac remodeling and function in both mouse and porcine MI models. Local inhibition of miR-146b-5p may represent a novel therapeutic approach to treat cardiac fibrotic remodeling and dysfunction following MI.
Prostaatspecifiek membraanantigeen radioligandtherapie met alfastralers, een review
Authors: Privé Bastiaan M. , van Gemert Willemijn A. M. , Nagarajah James , Mehra Niven , Gerritsen Winald R. , van Oort Inge M. , Gotthardt Martin , Heskamp Sandra , Janssen Marcel J. R. 
Published: August 2020

SamenvattingProstaatspecifiek membraanantigeen (PSMA) radioligandtherapie is een veelbelovende experimentele behandeling voor gemetastaseerd prostaatcarcinoom. In de nog lopende fase III-studie wordt lutetium-177 (177Lu)-PSMA, een bètastraler, gebruikt. Er wordt momenteel echter ook op beperkte schaal geëxperimenteerd met alfastralers die zijn gekoppeld aan PSMA-liganden, met name actinium-225 (225Ac)-PSMA. In vergelijking met bètastralers leiden alfastralers tot moeizamer herstellende DNA-schade, waarmee ze mogelijk effectiever zijn en een betere immunologische respons geven. Daarnaast hebben alfastralers een veel geringer doordringend vermogen, wat een voordeel zou kunnen zijn bij patiënten met diffuse beenmergmetastasering en bij patiënten met micrometastasen. De bijwerkingen op de speekselklieren zijn echter waarschijnlijk wel ernstiger. Net als bij bèta-PSMA-therapie is alfa-PSMA-therapie vooralsnog experimenteel. Het effect van alfastralers is enkel onderzocht in retrospectieve series – er zijn nog geen prospectieve of vergelijkende studies verricht – waardoor de resultaten voorzichtig moeten worden geïnterpreteerd. De wereldwijde productie van 225Ac en andere alfastralers zou bovendien fors moeten worden opgeschaald om klinische studies en grootschalig gebruik mogelijk te maken. In deze review geven we een overzicht van de eerste klinische data omtrent alfa-PSMA-therapie.
CEEMDAN-IMFx-PCA-CICA: an improved single-channel blind source separation in multimedia environment for motion artifact reduction in ambulatory ECG
Authors: Xiong Fan , Chen Dongyi 
Published: August 2020

AbstractLong-term monitoring of ECG via wearable monitoring systems has already been widely adopted to detect and prevent heart diseases. However, one of the main issues faced by wearable ECG monitoring systems is that motion artifacts significantly affect the systems' stability and reliability. Therefore, motion artifact reduction is a very challenging task in filtering and processing physiological signals. Based on the existing algorithms and ECG prior knowledge, in this paper, we propose an algorithm, CEEMDAN-IMFx-PCA-CICA, for motion artifact reduction in ambulatory ECG signals using single-channel blind source separation technique. Our algorithm first utilizes CEEMDAN to decompose the mixed signals into IMFs (intrinsic mode function) containing different source signal features, thereby forming new multi-dimensional signals. Using the correlation between IMFx (IMF component with the most ECG features) and each IMF, and PCA are then applied to reduce the dimension of each IMF. Finally, the blind separation of the source ECG signals is achieved by using CICA with IMFx as the constraint reference component. The results of our experiments indicate that our algorithm outperformed CEEMDAN-CICA, CEEMDAN-PCA-CICA, and improved CEEMDAN-PCA-CICA. Besides, the number of iterations of the CICA is significantly reduced; the separated source signal is better; the obtained result is stable. Furthermore, the separated ECG signal has a higher correlation with the source ECG signal and a lower RRMSE, especially in the case of high noise-to-signal ratios.
Shannon entropy in time-varying semantic networks of titles of scientific paper
Authors: Vale Cunha Marcelo do , Ribeiro Santos Carlos Cesar , Moret Marcelo Albano , de Barros Pereira Hernane Borges 
Published: August 2020

AbstractRecent work has employed information theory in social and complex networks. Studies often discuss entropy in the degree distributions of a network. However, no specific work on entropy exists in clique networks. This work is an extension of a previous study that discussed this topic. We propose a method for calculating the entropy of a clique network and its minimum and maximum values in temporal semantic networks based on titles of scientific papers. In addition, the critical network of moments was extracted. We use the titles of scientific papers published in Nature and Science over ten-year period. The results show the diversity of vocabulary over time, based on the entropy values of vertices and edges. In each critical network, we discover the paths that connect important words and an interesting modular structure.
Exploring dynamic multilayer graphs for digital humanities
Authors: Bornhofen Stefan , Düring Marten 
Published: August 2020

AbstractThe paper presents Intergraph, a graph-based visual analytics technical demonstrator for the exploration and study of content in historical document collections. The designed prototype is motivated by a practical use case on a corpus of circa 15.000 digitized resources about European integration since 1945. The corpus allowed generating a dynamic multilayer network which represents different kinds of named entities appearing and co-appearing in the collections. To our knowledge, Intergraph is one of the first interactive tools to visualize dynamic multilayer graphs for collections of digitized historical sources. Graph visualization and interaction methods have been designed based on user requirements for content exploration by non-technical users without a strong background in network science, and to compensate for common flaws with the annotation of named entities. Users work with self-selected subsets of the overall data by interacting with a scene of small graphs which can be added, altered and compared. This allows an interest-driven navigation in the corpus and the discovery of the interconnections of its entities across time.
hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets
Authors: Zhang Qiong , Liu Wei , Zhang Hong-Mei , Xie Gui-Yan , Miao Ya-Ru , Xia Mengxuan , Guo An-Yuan 
Published: August 2020

Abstract
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF–target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene expression. The accumulated data of chromatin immunoprecipitation sequencing (ChIP-seq) provide great opportunities to discover the TF–target regulations across different conditions. In this study, we constructed a database named hTFtarget, which integrated huge human TF target resources (7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs) and epigenetic modification information to predict accurate TF–target regulations. hTFtarget offers the following functions for users to explore TF–target regulations: (1) browse or search general targets of a query TF across datasets; (2) browse TF–target regulations for a query TF in a specific dataset or tissue; (3) search potential TFs for a given target gene or non-coding RNA; (4) investigate co-association between TFs in cell lines; (5) explore potential co-regulations for given target genes or TFs; (6) predict candidate TF binding sites on given DNA sequences; (7) visualize ChIP-seq peaks for different TFs and conditions in a genome browser. hTFtarget provides a comprehensive, reliable and user-friendly resource for exploring human TF–target regulations, which will be very useful for a wide range of users in the TF and gene expression regulation community. hTFtarget is available at http://bioinfo.life.hust.edu.cn/hTFtarget.
Disaster Response to a Mass Casualty Incident in a Hospital Fire by Regional Disaster Medical Assistance Team: Characteristics of Hospital Fire
Authors: Jang Jae Ho , Cho Jin-Seong , Lim Youg Su , Hyun Sung Youl , Woo Jae-Hyug , Choi Woo Sung , Choi Jae Yeon , Yang Hyuk Jun 
Published: August 2020

ABSTRACTObjective:A disaster in the hospital is particularly serious and quite different from other ordinary disasters. This study aimed at analyzing the activity outcomes of a disaster medical assistance team (DMAT) for a fire disaster at the hospital.Methods:The data which was documented by a DMAT and emergent medical technicians of a fire department contained information about the patient’s characteristics, medical records, triage results, and the hospital which the patient was transferred from. Patients were categorized into four groups according to results of field triage using the simple triage and rapid treatment method.Results:DMAT arrived on the scene in 37 minutes. One hundred and thirty eight (138) patients were evacuated from the disaster scene. There were 25 patients (18.1%) in the Red group, 96 patients (69.6%) in the Yellow group, and 1 patient (0.7%) in the Green group. One patient died. There were 16 (11.6%) medical staff and hospital employees. The injury of the caregiver or the medical staff was more severe compared to the family protector.Conclusions:For an effective disaster-response system in hospital disasters, it is important to secure the safety of medical staff, to utilize available medical resources, to secure patients’ medical records, and to reorganize the DMAT dispatch system.
Tensile strength of glacial ice deduced from observations of the 2015 eastern Skaftá cauldron collapse, Vatnajökull ice cap, Iceland
Authors: Ultee Lizz , Meyer Colin , Minchew Brent 
Published: August 2020

AbstractThe representation of iceberg calving in numerical models is a key source of uncertainty in century-scale sea-level rise projections. Parameters central to model representations of calving, including the tensile strength of glacier ice, remain poorly constrained. Grain-size and sample-size dependence make it difficult to reconcile laboratory and in situ estimates of ice tensile strength. Further, assumptions of various numerical models obscure comparison of the ‘strength’ parameter with a physically observable value. Here, we address the problem of fracture during calving using an analogous natural laboratory: a viscoelastic analysis of observed surface deformation and associated stresses in the 2015 collapse of eastern Skaftá cauldron, Vatnajökull ice cap, Iceland. We find that the ice within the cauldron could have experienced instantaneous elastic stress on the order of several MPa. We observe surface crevasses at the cauldron edges and center, but find that large areas of ice remain intact despite high stress. Our findings suggest a tensile strength of glacier ice on the order of 1 MPa, consistent with laboratory estimates but exceeding previous glacier-specific estimates.
THE KUZNETS CURVE IN BRAZIL, 1850-2010
Authors: Gómez León María 
Published: August 2020

ABSTRACTUsing social tables and modern household surveys, this article explores Brazil's income distribution from a historical perspective (1850-2010), examining its relationship with economic development and the factors driving inequality changes. It shows that Brazil's inequality was not always high, but rather followed a Kuznets curve, increasing from the early 20thcentury, reaching a high plateau between the 1970s and 1990s and declining thereafter. Notably, results highlight the importance of both economic and political factors for enabling the completion of the second Kuznets curve phase.
Learning from a case of right ventricular outflow tract stenting in tricuspid atresia with critical pulmonary stenosis
Authors: Awasthy Neeraj , Chimoriya Romila , Kumar Gaurav 
Published: August 2020

AbstractTricuspid valve atresia with severe pulmonary stenosis is one of the common cyanotic diseases in neonate. Child can succumb due to profound cyanosis and arterial hypoxaemia after closure of patent ductus arteriosus. Evolving procedure of right ventricular outflow tract stenting may be considered as a palliative procedure in such vulnerable group, destined for a later definitive management. The right ventricular outflow tract stenting is described essentially for tetralogy of Fallot physiology with a catheter course across tricuspid valve. We describe a case of successful right ventricular outflow tract stenting in a 5-day-old symptomatic neonate. We discuss the possible routes and the tips to facilitate right ventricular outflow tract stenting in such a case. This happens to be the first reported case description with successful stenting of neonate with tricuspid atresia with critical pulmonic stenosis.
Design activism: catalysing communities of practice
Authors: Mallo Daniel , Tardiveau Armelle , Parsons Rorie 
Published: August 2020

Over the last decade, we have witnessed renewed interest in design as a socially engaged practice. Much of the debates around ‘social design’ point towards myriad approaches and disciplinary fields interwoven with grass-roots initiatives and social movements. Among these, design activism has gained traction as critical spatial practice that operates on the fringes of commercial and institutional spheres.The temporal, spatial and experimental nature of design activism is well delineated in scholarship but its long-term effect on everyday urban environments remains elusive. Moreover, the influence of design activism on socio-spatial dynamics is indeed largely under researched. By mobilising social practice theory, this paper proposes a novel theorisation of design activism that sheds light on the social formations and collective practices catalysed through the activist impulse. This ontological shift embraces an understanding of the socio-material world through practice. Such characterisation of design activism underscores collective moments of integration of the constitutive elements of practice, encapsulated by Shove, Pantzar and Watson as ‘material, competence and meaning’.The authors' own empirical research, funded by the Economic and Social Research Council (ESRC) in the UK, reveals design activism as necessarily intertwined with other everyday practices – gardening, celebrating, playing – that coalesce around a shared sense of citizenship. It also advances the role of design activism in forging communities of practice: mutually supportive and self-sustaining groups emerging out of the personal relations sustained and organised around a practice of place making.
Living with buildings, living with microbes: probiosis and architecture
Authors: Ramirez-Figueroa Carolina , Beckett Richard 
Published: August 2020

In this paper we establish a dialogue with Living with Buildings to contextualise NOTBAD (Niches for Organic Territories in Bio-Augmented Design), a multidisciplinary research project at the intersection of architecture and microbiology, sited within a wider historical discourse connecting architecture and health. Living with Buildings (2018) was organised by the Wellcome Trust to trace the changing landscape of health and architecture, setting out to show how connections between the ways we feel and the places in which we spend our lives have historically evolved as our ideas about health and disease have changed. Taking our cue from the pieces at the exhibition, we discuss how the eighteenth century saw the emergence of an imaginary of cleanliness linked to miasma theory, locating bad smells and odours as the origin of disease and resulting in the adoption of rituals of purification in buildings. Treatments of plastering, coating and whitewashing popularised in the nineteenth century are testament to a shift from olfactory to visual codes of hygiene and to the ‘antibiotic turn’ in architecture.We extend the historical analysis to suggest that architecture finds itself at a crossroads. Although there is a growing understanding of how much architecture influences our wellbeing, architectural thought still clings to the antibiotic turn. Following the tradition of exchange between architecture and medicine, we propose the notion of Probiotic Architecture as a way of framing the shifting understanding of health in architectural design, suggesting that the microorganisms that colonise humans (the human microbiome) and our built environment (the built environment microbiome) have the potential to influence our health and the resilience of our buildings. Against the backdrop of the design research project Niches for Organic Territories in Bio-Augmented Design (NOTBAD), we suggest the need to reverse notions that all microbes are bad, to and propose instead materials and prototypes that encourage benign microbial growth.
Ultra-processed foods and early childhood caries in 0–3‐year‐olds enrolled at Primary Healthcare Centers in Southern Brazil
Authors: de Souza Maurício Santos , Vaz Juliana dos Santos , Martins-Silva Thais , Bomfim Rafael Aiello , Cascaes Andreia Morales 
Published: August 2020

AbstractObjective:To investigate the relationship between ultra-processed food consumption and early childhood caries.Design:Cross-sectional analysis of baseline data from a cluster randomised controlled study. Outcomes included the prevalence of children with non-cavitated and cavitated caries. The main exposure was the total daily consumption of ultra-processed foods (up to three times and four times or more), assessed through a FFQ. Potential confounders were socio-demographic characteristics of the child and caregiver/family, child breast-feeding, oral hygiene and use of dental services. Poisson regression using robust variance adjustment was used to estimate prevalence ratios (PR) and their respective 95 % CI.Setting:Primary Healthcare Centers in an urban area of Pelotas, Southern Brazil.Participants:Children aged 0–3 years (n 309).Results:Consumption of ultra-processed foods four times or more a day was found in 67·6 % of children; 24·4 and 12·0 % presented non-cavitated and cavitated caries, respectively. After adjustment, children who consumed ultra-processed foods four times or more a day were more likely to present both non-cavitated caries (PR 2·25, 95 % CI 1·19, 4·27, P = 0·013) and cavitated caries (PR 3·48, 95 % CI 1·18, 10·30, P = 0·024) compared with those who have consumed them up to three times a day.Conclusions:Consumption of ultra-processed foods is associated with early childhood caries. Interventions aiming at reducing ultra-processed food consumption should be implemented to improve children’s oral health.
The interstellar communication relay
Authors: McConnell Brian 
Published: August 2020

AbstractThe paper describes the architecture for a data repository and distribution system to be used in the case of a SETI detection event. This system is conceptually modelled after the Deep Space Network, although the hardware and infrastructure involved are different and substantially less expensive to operate. The system is designed to accommodate a large number of users from a variety of fields who wish to contribute to the analysis and comprehension effort that would follow the detection of an information-bearing signal.
Periodic printed semi-annular substrate loaded TM01–TE11 mode converter
Authors: Chittora Ashish , Yadav Swati Varun 
Published: August 2020

AbstractA mode converter design using the concept of periodic substrates loading in a circular waveguide, to convert TM01 mode to TE11 mode is presented in this paper. The detailed design principle, simulation, and measurement results are included in this study. Simulation results show that the purity of output fundamental TE11 mode of the converter approaches 99.2% for an operating frequency of 3.2 GHz. The mode conversion efficiency is more than 90% over 3.07–3.25 GHz band and the relative bandwidth is 5.6% (180 MHz). The proposed TM01–TE11 mode converter has advantages, such as the compact, lightweight structure, high conversion efficiency, and proper bandwidth. The fabrication cost is relatively low and the structure is easy to fabricate. The power-handling capability is limited to 10 MW due to dielectric-based design. The compactness and portability of the system (e.g. Space applications, Accelerators, High Power Microwave) can be improved significantly using the proposed mode converter.