bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pertumbuhan Dana Pihak Ketiga Terhadap Laba Perbankan Syariah di Indonesia
Authors: Nirwana Lutfiyah Putri , Septiarini Dina Fitrisia 
Published: October 2020

This research was aimed to find out the partial asnd simultaneous effect of wadi'ah current account, wadi'ah savings, mudharabah saving, and mudharabah deposits to profits in Islamic Banking. This research used quantitative approach. Statistical tool used is the multiple regression time series. The population in this research was Islamic banking industry recorded in Indonesian bank. The sample used is the Islamic Banks and Islamic Business Unit which data summarized in statistical reports of Islamic banking. The research period is January 2009 - October 2014. The simultaneous test resulst were wadi'ah current account, wadi'ah savings, mudharabah saving, and mudharabah deposits simultaneously had significant effect on profits of Islamic banking. The partial test showed that wadi'ah savings has significant effect against Islamic banking profit whereas of wadi'ah current account, mudharabah saving, and mudharabah deposits has no significant effect to Islamic banking profit.
Gadai Emas Alternatif Tambahan Modal Usaha Mikro Kecil dan Menengah Pada Lembaga Keuangan Syariah
Authors: Ardiani Ninda , Nafik HR Muhammad 
Published: October 2020

The method used is a qualitative approach with the strategy case study. The collection of data that is passed is the interview to the informant, the assistant pawn Islamic financial institutions and Micro, Small and Medium Enterprises customers pawn gold. The analysis technique used is the technique of pairing patterns with narrating the interviews with informants. Results from this study is the gold pawn Islamic financial institutions may be a reinforcement of capital Micro, Small and Medium Enterprises. The use of gold as a pledge of capital strengthening of capital Micro, Small and Medium Enterprises undertaken to meet short-term capital in the form of working capital. Requirements are simple and fast process makes this product desirable pengusha Micro, Small and Medium Enterprises. Using gold as a pledge of additional capital, the of capital Micro, Small and Medium Enterprises business grew and developing States.
Comparative transcriptome analysis reveals evolutionary divergence and shared network of cold and salt stress response in diploid D-genome cotton
Authors: Xu Yanchao , Magwanga Richard , Jin Dingsha , Cai Xiaoyan , Hou Yuqing , Juyun Zheng , Agong Stephen Gaya , Zhou Baoliang , Wang Kunbo , Liu Fang , Zhou Zhongli 
Published: October 2020

Abstract
Background: Wild species of cotton are excellent resistance to abiotic stress. Diploid D-genome cotton showed abundant phenotypic diversity and was the putative donor species of allotetraploid cotton which produce the largest textile natural fiber.Results: A total of 41,053 genes were expressed in all samples by mapping RNA-seq Illumina reads of G. thurberi (D1), G. klotzschianum (D3-k), G. raimondii (D5) and G. trilobum (D8) to reference genome. The numbers of differently expressed genes (DEGs) were significantly higher under cold stress than salt stress. However, 34.1% DEGs under salt stress were overlapped with cold stress in four species. Notably, a potential shared network (cold and salt response, including 16 genes) was mined out by gene co-expression analysis. A total of 47,180- 55,548 unique genes were identified in four diploid species by De novo assembly. Furthermore, 163, 344, 330, and 161 positively selected genes (PSGs) were detected in thurberi, G. klotzschianum, G. raimondii and G. trilobum by evolutionary analysis, respectively, and 9.5% - 17% PSGs of four species were DEGs in corresponding species under cold or salt stress. What’s more, most of PSGs were enriched GO term related to response to stimulation. G. klotzschianum showed the best tolerance under both cold and salt stress. Interestingly, we found that a RALF-like protein coding gene not only is PSGs of G. klotzschianum, but also belongs to the potential shared network.Conclusion: Our study provided new evidence that gene expression variations of evolution by natural selection were essential drivers of the morphological variations related to environmental adaptation during evolution. Additionally, there exist shared regulated networks under cold and salt stress, such as Ca2+ signal transduction and oxidation-reduction processes. Our work establishes a transcriptomic selection mechanism for altering gene expression of the four diploid D-genome cotton and provides available gene resource underlying multi-abiotic resistant cotton breeding strategy.
Clinical outcomes of early gastric cardiac cancer treated with endoscopic submucosal dissection in patients with different indications
Authors: Fan Ting , Sun Qi , Cao Shouli , Fan Xiangshan , Huang Qin , Zhang Shu , Lv Ying , Zhang Xiaoqi , Ling Tingsheng , Wang Lei , Zou Xiaoping , Xu Guifang 
Published: October 2020

Abstract
Background: Endoscopic submucosal dissection (ESD) has been accepted as a standard treatment for early gastric cardiac cancer (EGCC). Here, we investigate the clinical outcomes of the EGCC patients who underwent ESD in different indications.Methods: From January 2011 to October 2019, we enrolled 502 EGCC lesions from 495 patients which were resected by ESD at our center. We retrospectively analyzed the short-term and long-term clinical outcomes among different indication groups.Results: The number of the patients in the absolute indication (AI), expanded indication (EI) and beyond the expanded indication (BEI) groups was 265, 137 and 93, respectively. The en bloc resection rate was 100%, 100% and 98.9% (P=0.185). The complete resection rate was 99.3%, 98.5% and 74.5%, respectively (P<0.001). During a median follow-up of 48.1 months, the lymph node metastasis rate was 0%, 0% and 2.3% (P<0.001). The distant metastasis rate was 0.4%, 0% and 2.3% (P=0.150). The five-year disease-specific survival rate in the BEI group was 96.6% (P=0.016), compared to 99.6% in the AI group and 100% in the EI group.Conclusion: The efficacy for ESD patients in EI group was almost equal to the AI group. Patients in the BEI group showed generally favorable clinical outcomes and needed to be carefully checked after ESD. ESD may be an optional treatment for patients unsuitable for gastrectomy.
Metabonomics coupled with integrated approach reveals the therapeutic effect of higenamine combined with [6]-gingerol on doxorubicin - induced chronic heart failure in rats
Authors: Wen Jianxia , Ma Xiao , Niu Ming , Hao Junjie , Huang Ying , Wang Ruilin , Li Ruisheng , Wang Jian , Zhao Yanling 
Published: October 2020

Abstract
The combination of Aconiti Lateralis Radix Praeparata (ALRP) and Zingiberis Rhizoma (ZR) is one of the most typical representatives reflecting the very essence of the theory of Chinese material medica compatibility, which has been used to treat cardiovascular disease for many years. Previously, we demonstrated that ALRP-ZR prevented doxorubicin (DOX)-induced chronic heart failure (CHF) in vivo. However, its active components are still unclear. This study was aimed to investigate the therapeutic effect and potential mechanism of higenamine combined with [6]-gingerol (HG/[6]-GR) against doxorubicin (DOX) - induced chronic heart failure (CHF) in rats. Therapeutic effects of HG/[6]-GR on hemodynamics indices, serum biochemical indicators, histopathology and TUNEL staining of rats were assessed. Moreover, a UHPLC-Q-TOF/MS-based serum metabonomic approach coupled with biochemical assay has been performed to identify the potential mechanisms of HG/[6]-GR on DOX-induced CHF. HG/[6]-GR had effects on promoting of hemodynamic indices, decreasing serum biochemical indicators, and alleviating histological damage of heart tissue. Serum metabonomics analyses indicated that the therapeutic effects of HG and [6]-GR were mainly associated with the regulation of eight metabolites and twelve pathways, which may be responsible for the therapeutic efficacy of HG/[6]-GR. Moreover, the results showed that HG/[6]-GR could substantially regulate the expression level of energy metabolism-related metabolites and pathways. Multivariate statistical analysis has provided new insights for understanding CHF and investigating the therapeutic effects and mechanisms of HG/[6]-GR, which influencing the metabolites related to energy metabolism pathway.
SETDB1 promotes glioblastoma growth via CSF-1 - dependent macrophage recruitment by activating the AKT/mTOR signaling pathway
Authors: Han Shuai , Zhen Wei , Guo Tongqi , Zou Jianjun , Li Fuyong 
Published: October 2020

Abstract
Background: Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which are important factors in glioblastoma progression. However, the exact details of TAMs in glioblastoma progression have yet to be determined. Methods: The clinical relevance of SET domain bifurcated 1 (SETDB1) was analyzed by immunohistochemistry, real-time PCR and Western blotting of glioblastoma tissues. SETDB1-induced cell proliferation, migration and invasion were investigated by CCK-8 assay, colony formation assay, wound healing and Transwell assay. The relationship between SETDB1 and colony stimulating factor 1 (CSF-1), as well as TAMs recruitment was examined by Western blotting, real-time PCR and syngeneic mouse model.Results: Our findings showed that SETDB1 upregulated in glioblastoma and relative to poor progression. Gain and loss of function approaches showed the SETDB1 overexpression promotes cell proliferation, migration and invasion in glioblastoma cells. However, knockdown SETDB1 exerted opposite effects in vitro. Moreover, SETDB1 promotes AKT/mTOR-dependent CSF-1 induction and secretion, which leads to macrophage recruitment in the tumor, resulted in tumor growth. Conclusion: Our research clarified that SETDB1 regulates of tumor microenvironment and hence presents a potential therapeutic target for treating glioblastoma.
Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention
Authors: Claire Ravinder , Gluud Christian , Berlin Ivan , Coleman Tim , Leonardi-Bee Jo 
Published: October 2020

Abstract
Background: Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the design and sample size of the adequately powered randomised clinical trials. When a randomised clinical trial is conducted, results from feasibility and pilot trials may be disregarded in terms of benefits and harms.Methods: We describe using feasibility and pilot trial data in the Trial Sequential Analysis software to estimate the required sample size for one or more trials investigating a behavioural smoking cessation intervention. We show how data from a new, planned trial can be combined with data from the earlier trials using trial sequential analysis methods to assess the intervention's effects. Results: We provide a worked example to illustrate how we successfully used the Trial Sequential Analysis software to arrive at a sensible sample size for a new randomised clinical trial and use it in the argumentation for research funds for the trial. Conclusions: Trial Sequential Analysis can utilise data from feasibility and pilot trials as well as other trials, to estimate a sample size for one or more, similarly designed, future randomised clinical trials. As this method uses available data, estimated sample sizes may be smaller than they would have been using conventional sample size estimation methods.
Genome-wide characterization and expression analysis of the heat shock transcription factor family in pumpkin (Cucurbita moschata)
Authors: Shen Changwei , Yuan Jingping 
Published: October 2020

Abstract
Background: Crop quality and yield are affected by abiotic and biotic stresses, and heat shock transcription factors (Hsfs) are considered to play important roles in regulating plant tolerance under various stresses. To investigate the response of Cucurbita moschata to abiotic stress, we analyzed the genome of C. moschata.Results: In this research, a total of 36 C. moschata Hsf (CmHsf) members were identified and classified into three subfamilies (I, II, and III) according to their amino acid sequence identity. The Hsfs of the same subfamily usually exhibit a similar gene structure (intron-exon distribution) and conserved domains (DNA-binding and other functional domains). Chromosome localization analysis showed that the 36 CmHsfs were unevenly distributed on 18 of the 21 chromosomes (except for Cm_Chr00, Cm_Chr08 and Cm_Chr20), among which 18 genes formed 9 duplicated gene pairs that have undergone segmental duplication events. The Ka/Ks ratio showed that the duplicated CmHsfs have mainly experienced strong purifying selection. High-level synteny was observed between C. moschata and other Cucurbitaceae species.Conclusions: The expression profile of CmHsfs in the roots, stems, cotyledons and true leaves revealed that the CmHsfs exhibit tissue specificity. The analysis of cis-acting elements and quantitative real-time polymerase chain reaction (qRT-PCR) revealed that some key CmHsfs were activated by cold stress, heat stress, hormones and salicylic acid. This study lays the foundation for revealing the role of CmHsfs in resistance to various stresses, which is of great significance for the selection of stress-tolerant C. moschata.
Autoregressive Cross-Lagged Modeling of The Longitudinal Relationship Between Sub-Health and Cold Hypersensitivity
Authors: Jin Hee-Jeong , Kim Sujung , Lee Siwoo 
Published: October 2020

Abstract
Background: Sub-health refers to abnormal symptoms that occur in the body, but with no specific disease, and a high probability of future diseases. Meanwhile, cold hypersensitivity is one of the most basic diagnosis methods used in Oriental medicine for explaining a patient’s health status, and various studies have supported its association with health status. The present study analyzed differences in cold hypersensitivity regarding health status and examined changes in health status and cold hypersensitivity over time. Methods: The health status and cold hypersensitivity of 255 adults from Daejeon in South Korea were examined. To assess the longitudinal relationship between health status and cold hypersensitivity, data at baseline, 6-month follow-up, and 12-month follow-up were used for analysis using an autoregressive cross-lagged model (ARCLM).Results: ARCLM analysis showed that the path coefficients of each autoregressive coefficient (baseline to 6-month follow-up, 6-month follow-up to 12-month follow-up) of health status and cold hypersensitivity moving from measurement time point t to t+1 were significant in all time intervals. The same was true for health status patterns. Thus, these findings suggested that health status and cold hypersensitivity were not transient symptoms but persisted over time. The findings also showed that health status had a significant cross-lagged effect on cold hypersensitivity.Conclusions: Health status and cold hypersensitivity were found to be stable and associated with each other over time. Therefore, consistent care is necessary to maintain health status and treat cold hypersensitivity. The longitudinal data used in this study to examine the causal relationship between health status and cold hypersensitivity demonstrate the diagnostic value of cold hypersensitivity and the need for health status-based interventions.
The Components of Workplace Violence against Nurses from the Perspective of Women Working in a Hospital in Tehran: A Qualitative Study
Authors: Mansourian Morteza , Faghihi Mitra , Farshad Aliasghar , Abhari Maryam Biglari , Azadi Nammamali 
Published: October 2020

Abstract
Background: Based on the World Health Organization (WHO), workplace violence can affect events where employees are abused, threatened or attacked in their workplace, and it also has some consequences such as safety, welfare, and health. Like other types of violence, workplace violence and aggression is an increasing phenomenon. Moreover, workplace violence not only disrupts interpersonal and organizational relationships, but it also impairs people's self-esteem and affects their physical and mental health and well-being. Thus, the present study aimed to explain the components of workplace violence against nurses from the perspective of women working in a hospital in Tehran, which was conducted through the qualitative method and content analysis.Methods: Purposive sampling included 21 female nurses who were working in different wards of the hospital. Also, female nurses were selected with maximum diversity in terms of age, work experience, and the wards they were working in. The semi-structured interview was the main method of data collection in this study. The interview transcriptions were extracted and then divided into meaningful units. For strengthening and confirming the results and accuracy of the research, the author used the data credibility, acceptability, validity, accuracy, believability, verifiability, reliability, and transferability.Results: During the data analysis process, the first 15 classes with the same characteristics were put together and then divided into 6 classes. Afterward, based on the common features at a more abstract level, they were converted into 2 themes. Based on the findings, violence against women in the workplace occurs at two levels, namely interpersonal violence and organizational coercion.Conclusions: Therefore, it is necessary for managers to commit to lay the groundwork for reducing violence in the hospital, to lower the level of violence in workplaces, as well as barriers to report these cases especially in hospitals, and managers and officials’ awareness on violence in these workplaces must effort to prevent and reduce it.
Stimulation-induced differential redistributions of clathrin and clathrin-coated vesicles in axons compared to soma/dendrites
Authors: Tao-Cheng Jung-Hwa 
Published: October 2020

Abstract
Clathrin-mediated endocytosis plays an important role in the recycling of synaptic vesicle in presynaptic terminals, and in the recycling of transmitter receptors in neuronal soma/dendrites. The present study uses electron microscopy (EM) and immunogold EM to document the different categories of clathrin-coated vesicles (CCV) and pits (CCP) in axons compared to soma/dendrites, and the depolarization-induced redistribution of clathrin in these two polarized compartments of the neuron. The size of CCVs in presynaptic terminals (~40 nm; similar to the size of synaptic vesicles) is considerably smaller than the size of CCVs in soma/dendrites (~90 nm). Furthermore, neuronal stimulation induces an increase in the number of CCV/CCP in presynaptic terminals, but a decrease in soma/dendrites. Immunogold labeling of clathrin revealed that in presynaptic terminals under resting conditions, the majority of clathrin molecules are unassembled and concentrated outside of synaptic vesicle clusters. Upon depolarization with high K+, label for clathrin became scattered among de-clustered synaptic vesicles and moved closer to the presynaptic active zone. In contrast to axons, clathrin-labeled CCVs and CCPs were prominent in soma/dendrites under resting conditions, and became inconspicuous upon depolarization with high K+. Thus, EM examination suggests that the regulation and mechanism of clathrin-mediated endocytosis differ between axon and dendrite, and that clathrin redistributes differently in these two neuronal compartments upon depolarization.
Differential Effects of Encapsulation of Rat ADSCs in Fibrin Matrix and Combination Delivery of BDNF and Gold Nanoparticles on Peripheral Nerve Regeneration
Authors: Razavi Shahnaz , Jahromi Maliheh , Vatankhah Elham , Seyedebrahimi Reihaneh 
Published: October 2020

Abstract
Background: Fibrin as an extracellular matrix feature like biocompatibility, creates a favorable environment for proliferation and migration of cells and acts as a reservoir for storage and release of growth factors in tissue engineering. Methods: In this study, the inner surface electrospun poly (lactic-co-glycolic acid) (PLGA) nanofibrous conduit was biofunctionalized with laminin containing brain derived neurotrophic factor (BDNF) and gold nanoparticles in chitosan nanoparticle. The rats were randomly divided into five groups, including autograft group as the positive control, PLGA conduit coated by laminin and filled with DMEM/F12, PLGA conduit coated by laminin and filled with adipose-derived stem cells (rADSCs) , PLGA conduit coated by laminin containing gold-chitosan nanoparticles (AuNPs-CNPs), BDNF-chitosan nanoparticles (BDNF-CNPs) and filled with rADSCs or filled with rADSCs suspended in fibrin matrix, and they were implanted to bridge a 10 mm rat sciatic nerve gap. Eventually, axonal regeneration and functional recovery were assessed after 12 weeks.Results: After 3months post-surgery period, the results showed that in the PLGA conduit filled with rADSCs without fibrin matrix group, positive effects were obtained as compared to other implanted groups by increasing the sciatic functional index significantly (p < 0.05). In addition, the diameter nerve fibers had a significant difference mean in the PLGA conduit coated by laminin and conduit filled with rADSCs in fibrin matrix groups relative to the autograft group (p< 0.001). However, G-ratio and amplitude (AMP) results showed that fibrin matrix might have beneficial effects on nerve regeneration but, immunohistochemistry and real-time PCR outcomes indicated that the implanted conduit which filled with rADSCs with or without BDNF-CNPs and AuNPs-CNPs had significantly higher expression of S100, MBP and NF200 markers than other conduit implanted groups (p< 0.05).Conclusions: It seems, in this study differential effects of fibrin matrix, could be interfered it with other factors thereby and further studies are required to determine the distinctive effects of fibrin matrix combination with other exogenous factors in peripheral nerve regeneration.
The Zierikzee Herbarium: An analysis of the contents and origins of an enigmatic herbarium
Authors: Offerhaus Aleida , de Haas Emma , Porck Henk , Kardinaal Adriaan , Ek Renske , Pokorni Omar , Andel Tinde van 
Published: October 2020

Abstract
The Municipal Museum of Zierikzee houses a loose-leafed herbarium containing 360 dried plant specimens, of which the provenance, age and maker were until recently unknown. By studying the plant specimens, paper, decorations and labels, an image was conveyed of an early 18th century herbarium that matched the description of a herbarium from the legacy of Jakob Ligtvoet, who was gardener in the Leiden Hortus botanicus from 1703 till his death in 1752. This herbarium is one of the oldest garden herbaria of its kind and contains 306 unique species, of which 201 are currently native to the Netherlands. Exotic species come from the Mediterranean (82 spp.), Europe (24), South Africa (8), the Americas (9) and in tropical Asia (7). Based on our comparison of names on the oldest labels, this collection of dried plants was probably started after publication of the first garden catalogue by the prefect of the Leiden garden and professor of botany Herman Boerhaave (1710), but before the second edition in 1719. This historic herbarium reflects the state-of-the-art of botanical science and the international network of Dutch botanical gardens in the early 18th century.