bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of chemotherapy-induced nausea and vomiting with acupuncture
Authors: Ma Ting-Ting , Zhang Tao , Zhang Gan-Lin , Dai Cun-Fang , Zhang Bo-Ran , Wang Xiao-Min , Wang Lin-Peng 
Published: January 2020

Abstract

Background:
Nausea and vomiting are the most common complications following chemotherapy and usually lead to decreased quality of life. Acupuncture therapy is an effective method for chemotherapy-induced nausea and vomiting (CINV), the effects and safety have been observed by many clinicians and demonstrated in a systematic review, which was included in the Cochrane Library in 2014. After several years, new studies have occurred and an updated systematic evaluation is needed. This protocol describes a method for performing a systematic review and meta-analysis to further evaluate the beneficial effects and safety of acupuncture for CINV.

Methods:
A searching strategy will be carried out mainly in eight databases in English and Chinese, Cochrane Central Register of Controlled Trials, PubMed, Embase, China National Knowledge Infrastructure, the Chinese Scientific Journal Database, the Wanfang database, China Doctoral Dissertations Full-text Database, and China Master's Theses Full-text Database. Only randomized controlled trials related to acupuncture for CINV will be included to enhance the effectiveness. The effective percentage will be used as primary outcome. Changes in the symptoms of nausea and vomiting, like severity, duration, and frequency as well as quality of life will be assessed as secondary outcome. Side effects and adverse events will be used as safety evaluations. To ensure the quality of the systematic evaluation, study selection, data extraction, and quality assessment will be independently performed by 2 authors, and the third author will deal with any disagreement. The Review Manager V.5.3.3 s will be used to perform the data synthesis and subgroup analysis.

Results:
There are additional studies, further explanations and more subgroup analyses compared with the previous systematic analysis to determine the effects and safety of acupuncture for CINV.

Conclusion:
The result of this systematic review may offer clinicians stronger evidence to assist patient in relieving CINV.

Ethics and dissemination:
There is no need to acquire ethical approval for individuals come from literatures instead of recruiting directly. The findings of this review will be reported in peer-reviewed publications and/or presented at relevant conferences

Trial registration number:
CRD42016045223.
Clinical study on concurrent use of electro-acupuncture or Chuna manual therapy with pregabalin for chemotherapy-induced peripheral neuropathy: safety and effectiveness (open-labeled, parallel, randomized controlled trial, assessor-blinded)
Authors: Lee Jin-Hyun , Cho Tae jin , Park Min Geun , Kim Ji-Hoon , Song Sung Kyu , Park Shin-Young , Sunwoo Yun-Young , Lee Ilkyun , Park Tae-Yong 
Published: January 2020

Abstract

Introduction:
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the major side effects of chemotherapy. Its main symptoms are pain, paresthesia, and numbness. However, the mechanisms underlying the development of CIPN remain unclear and standard treatments have not been established. Recently, there has been a growing interest in various approaches to overcome the limitations of the existing treatments. This study aims to evaluate the efficacy and safety of the concurrent use of two complementary and alternative therapies: electroacupuncture (EA) and Chuna manual therapy (CMT), with pregabalin, which is the conventional pharmacotherapy for neuropathic pain.

Methods/design:
This is an open-label, parallel, assessor-blinded randomized controlled trial, which includes 90 patients with colorectal and breast cancer, who developed CIPN. After a 2-week preparation period, the patients are divided into three groups (pregabalin administration group, pregabalin + EA treatment group, and pregabalin + CMT treatment group), treated for approximately 5 weeks and followed-up 4 weeks after treatment. The primary outcome is assessed using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity subscale score (version 4.0) and the secondary outcome is measured using the Quality of Life Questionnaire-CIPN 20-Item Scale (version 3.0) and the quality of life questionnaire (version 3.0) developed by the European Organisation for Research and Treatment of Cancer. Moreover, exploratory efficacy and safety evaluations will be conducted based on the chemotherapy-completion rate and nerve conduction studies.
Possible increased risk of colonic diverticular disease from alcohol intoxication or abuse
Authors: Tseng Yun-Jung , Lai Ching-Yuan , Wang Yu-Chiao , Chen Wei-Kung , Kao Chia-Hung , Chen Chun-Hung 
Published: January 2020

Abstract
Alcohol consumption has been suggested as a potential risk factor for diverticular diseases. This study investigated the association between alcohol intoxication or abuse and colonic diverticular disease (CDD).
Using the National Health Insurance Research Database of Taiwan from January 1, 2000, to December 31, 2008, 51, 866 subjects newly diagnosed with alcohol intoxication were enrolled in this study as the alcohol intoxication cohort. The control (nonalcohol intoxication) cohort was frequency-matched 1:4 by age, sex and index year. Data were analyzed using a Cox proportional hazards model.
The overall incidence of CDD (per 10,000 person-years) for the alcohol intoxication and control cohorts was 16.4 and 3.46, respectively. Compared with patients in the control cohort (95% confidence interval [CI] = 2.76–3.74), those with alcohol intoxication exhibited a 3.21-fold risk of CDD; the risk was particularly higher in male patients (adjusted hazard ratio [aHR] = 3.19, 95% CI = 2.72–3.74) and in those aged <45 years (aHR = 4.95, 95% CI = 3.91–6.27). The alcohol intoxication still had higher risk of CDD than nonalcohol intoxication, regardless of subjects without comorbidity (aHR = 3.38, 95% CI = 2.77–4.11) or with (aHR = 2.85, 95% CI = 2.25–3.61).
There was a significant relationship between alcohol intoxication or abuse and CDD.
The relationship between low serum calcium level and intracerebral hemorrhage hematoma expansion
Authors: Sun Jian , Liu Wanjun , Zhu Rending , Wu Yao , Yang Liqi 
Published: January 2020

Abstract

Background:
To investigate the relationship between intracerebral hemorrhage hematoma expansion with low serum calcium level.

Methods:
We will search the following electronic bibliographic databases: MEDLINE, Embase, PubMed, The Cochrane Library, and Web of Science. All sources have to be searched from the earliest date until May 1, 2019. The quality of the included studies will assess by 2 evaluation members according to the Cochrane Collaboration network standard or the Newcastle–Ottawa Scale. The included studies will analysis by using RevMan 5.3 software.

Results and conclusion:
This will be the first systematic review and meta-analysis to evaluate the association of hematoma following intracerebral hemorrhage with hypocalcemia. The study will provide more reliable, evidence-based data for clinical decision making.

Prospero registration number:
CRD42019135956
Protocol of a meta-analysis
Authors: Liu Wanjun , Sun Jian , Wu Yao , Yang Liqi 
Published: January 2020

Abstract

Background:
The purpose of this study was to evaluate the effectiveness and safety of long fusion (LF) versus short fusion (SF) for the treatment of degenerative scoliosis (DS).

Methods:
We will search MEDLINE, EMBASE, PubMed, the Cochrane Library, and Web of Science to collect the randomized and non-randomized controlled studies that compared LF with SF in the treatment of DS from inception to June 1, 2019. The quality of the included studies will be assessed by 2 evaluation members according to the Cochrane collaboration network standard or the Newcastle–Ottawa Scale. The included studies will be analyzed using RevMan 5 (version 5.3.3).

Results and Conclusion:
The study will compare the efficacy and safety of LF and SF in the treatment of DS and provide more reliable, evidence-based data for clinical decision making.

PROSPERO registration number:
CRD42019137646.
Prolonged cholestasis following endoscopic retrograde cholangiopancreatography, a rare complication of contrast agent induced liver injury
Authors: Lin Cheng-Kuan , Huang Wen-Chih 
Published: January 2020

Abstract

Rationale:
Prolonged cholestasis is a rare complication associated with endoscopic retrograde cholangiopancreatography (ERCP).

Patient concerns:
A 68-year-old man who presented with worsening cholestasis after ERCP for the removal of a common bile duct stone.

Diagnosis:
Total bilirubin increased up to 35.2 mg/dL after the 21st day post-ERCP. A percutaneous liver biopsy was performed and drug-related cholestasis was suspected as occurring as a result of the contrast agent.

Interventions:
Oral ursodeoxycholic acid and cholestyramine were prescribed to the patient.

Outcomes:
By the 7th week post-ERCP, the patient's symptoms and markers of physiological health began to resolve. The bilirubin returned to normal levels on the 106th day post-ERCP. We reviewed the literature for studies of 9 patients with jaundice more than 30 days post-ERCP, the peak of total serum bilirubin occurred on 16th ± 7th days and the recovery followed after mean time of 54th ± 22th days.

Lessons:
Although the cholestasis was prolonged, the outcome was favorable after medical therapy. There were no long-term consequences for the patient.
A novel RNA sequencing-based prognostic nomogram to predict survival for patients with cutaneous melanoma
Authors: Tian Jun , Yang Ye , Li Meng-Yang , Zhang Yuan 
Published: January 2020

Abstract

Background:
Plenty of evidence has suggested that long non-coding RNAs (lncRNAs) have played a vital part may act as prognostic biomarkers in a variety of cancers. The aim of this study was to screen survival-related lncRNAs and to construct a lncRNA-based prognostic model in patients with cutaneous melanoma (CM).

Methods:
We obtained lncRNAs expression profiles and clinicopathological data from the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. A lncRNA-based prognostic model was established in training set. The established prognostic model was evaluated, and validated in the validation set. Then, a prognostic nomogram combining the lncRNA-based risk score and clinicopathological characteristics was developed in training set, and assessed in the validation set. The accuracy of the model was evaluated by the discrimination and calibration plots.

Results:
A total of 212 lncRNAs were identified to be differentially expressed in CM. After univariate analysis, LASSO penalized regression analysis, and multivariate analysis, 3 lncRNAs were used to construct risk score model. The proposed risk score model could divide patients into high-risk and low-risk groups with significantly different survival in both training set and validation set. The ROC curve showed good performance in survival prediction in both sets. Furthermore, the nomogram for predicting 3-, 5-, and 10-year OS was established based on lncRNA-based risk score and clinicopathologic factors. The prognostic accuracy of the risk model was confirmed by the discrimination and calibration plots in both training set and validation set.

Conclusions:
We established a novel three lncRNA-based risk score model and nomogram to predict overall survival of CM. The proposed nomogram may provide information for individualized treatment in CM patients.
Peripheral dentinogenic ghost cell tumor of the ethmoid sinus
Authors: Liu Guo , Li Jin-nan , Liu Feng 
Published: January 2020

Abstract

Rationale:
The dentinogenic ghost cell tumor (DGCT), a locally invasive benign neoplasm, is one of the rarest odontogenic tumors, usually developing in the maxilla or mandible. It can be classified into 2 types: intraosseous (central) and extraosseous (peripheral). Here, we describe the first case of a peripheral DGCT located in the ethmoid sinus.

Patient concerns:
An 8-year-old boy presented to our department with a longer than 7-month history of nasal obstruction, purulent secretion, and reduction in sense of smell in the right nasal cavity.

Diagnosis:
The patient was diagnosed with peripheral DGCT of the ethmoid sinus based on computed tomography scan and pathology.

Interventions:
Functional endoscopic sinus surgery was performed.

Outcomes:
With 2 years of follow-up, there was no evidence of recurrence.

Lessons:
Peripheral DGCT can occur in the paranasal sinus and the need to consider this entity as a possible diagnosis by the clinicians.
A nationwide peer-assisted learning program in disaster medicine for medical students
Authors: Ragazzoni Luca , Conti Andrea , Dell’Aringa Marcelo , Caviglia Marta , Maccapani Fabio , Della Corte Francesco 
Published: January 2020

Objectives
The Sendai Framework advocates the importance of training in disaster medicine as a way to improve health system resilience. In Italy, despite the official recognition of disaster medicine as a mandatory discipline in the standard curriculum, most students are never exposed to its basic concepts. DisasterSISM is a nationwide educational program in disaster medicine developed in 2008. Given the scarcity of experienced instructors, in 2013, the course adopted a peer-assisted learning (PAL) approach to correct the omission identified in the national curriculum. The new approach involved a training of trainers (ToT) and a basic course organized and delivered by certified student teachers.

Methods
The authors gathered and analyzed data from demographic questionnaires, pretest and posttests, and satisfaction questionnaires.

Results
From 2013 to 2018, 42 medical students attended the ToT becoming student teachers. From 2014 to 2018, 2316 medical students attended the basic course delivered by the student teachers across Italy. Thirty-six out of 41 medical schools were reached. Participation in the program improved students’ knowledge in disaster medicine. Participants were satisfied with both the course structure and its PAL approach and considered disaster medicine to be highly relevant for their future professional career.

Conclusions
By presenting this nationwide program and its outcomes, the authors hope to strengthen the case for including disaster medicine education in the standard medical curriculum. Because the course relies on medical students and PAL, the authors trust that it could be adapted to other countries worldwide.
Differentiating dural metastases from meningioma: role of 68Ga DOTA-NOC PET/CT
Authors: Purandare Nilendu C. , Puranik Ameya , Shah Sneha , Agrawal Archi , Gupta Tejpal , Moiyadi Aliasgar , Shetty Prakash , Shridhar Epari , Patil Vijay , Rangarajan Venkatesh 
Published: January 2020

Objective
To assess the ability of 68Ga DOTA-NOC PET/computed tomography (CT) to differentiate dural metastases from meningioma.

Patients and methods
Patients who underwent a 68Ga DOTA-NOC PET/CT for differentiating meningiomas from dural metastases were included in the study. A visual score was assigned to the dural lesions (visual score – 1 to 3) in relation to the uptake in liver and spleen and variation in the visual score was evaluated. SUVmax of the dural lesions was also noted and difference in the values of the two pathologies were compared for statistical significance using nonparametric statistical tests. Final diagnosis was decided by histopathological confirmation whenever available.

Results
Imaging, histopathology or follow-up data of 42 patients was available for analysis. Meningioma was the final diagnosis in 31 (73.8%) patients, whereas dural metastases were diagnosed in 9 (21.4%) patients. In two patients, histopathology revealed inflammatory pseudotumor and hemangioblastoma. Meningiomas showed intense tracer uptake in 30/31 patients (visual score 3). All metastatic lesions showed some degree of tracer uptake though the intensity was lesser compared to meningioma (visual score 1, 2). Meningiomas showed a significantly higher median SUV max value compared to metastases (12.7 vs. 6.0, P = 0.001).

Conclusion
Meningiomas can be differentiated from dural metastases by virtue of their higher uptake of 68Ga-labeled DOTA peptides reflecting higher SSTR expression. An asymptomatic meningeal based lesion with a high visual score (Visual score 3) has a very high probability to be a meningioma rather than dural metastasis.
Educating Students About Opioid Use Disorder and Treatments in the Community Using an Educational Video
Authors: Williams Kristiann T. , Baron Kristy A. , Gee Julie P. , Chan Julian 
Published: January 2020

Background
A treatment gap exists for people in the community with opioid use disorders (OUDs). Stigma and lack of knowledge of how to access community resources contribute to this gap. One valuable resource that may help fill this gap is nursing students.

Purpose
This study examined the impact of an educational video on prelicensure and postlicensure nursing students' knowledge and attitudes toward people with OUD.

Methods
A pre-post study design was used to examine whether 406 nursing students' knowledge and attitudes changed after viewing an educational video. Knowledge and attitudes were measured by an online survey, consisting of demographics, an 8-item Knowledge and Attitudes survey, and the Drug and Drug Problems Perceptions Questionnaire.

Results
The educational video produced a statistically significant positive improvement on nursing students' knowledge and attitudes.

Conclusion
Educating nursing students about OUD and treatment options can help reduce stigma and improve care toward people with OUD.
Self-efficacy and Satisfaction With Teaching in Online Courses
Authors: Hampton Debra , Culp-Roche Amanda , Hensley Angie , Wilson Jessica , Otts Jo Ann , Thaxton-Wiggins Amanda , Fruh Sharon , Moser Debra K. 
Published: January 2020

Background
Growth of online education has increased the demand for satisfied educators with perceived self-efficacy in online teaching. Teaching self-efficacy is an indicator of the belief that one can make a difference in student learning outcomes.

Purpose
The aim of this study was to examine the level of teaching self-efficacy and satisfaction of online nursing faculty.

Methods
This study used a descriptive cross-sectional survey design. Faculty satisfaction was measured by the Online Instructor Satisfaction Measure, and self-efficacy for online teaching was measured by the Michigan Nurse Educator's Sense of Efficacy for Online Teaching instrument.

Results
The sample included 100 faculty in multiple schools of nursing who taught at least 1 online course in RN to BSN or graduate nursing programs. Overall, participants had relatively high levels of online teaching self-efficacy and satisfaction.

Conclusions
Teacher self-efficacy can be facilitated through faculty development and increased experience teaching online.
Effect of Ultra High-Resolution Computed Tomography and Model-Based Iterative Reconstruction on Detectability of Simulated Submillimeter Artery
Authors: Morisaka Hiroyuki , Shimizu Yuta , Adachi Takuya , Fukushima Keita , Arai Takahiro , Yamamura Wataru , Koyanagi Masamichi , Kariyasu Toshiya , Machida Haruhiko , Sano Katsuhiro , Yokoyama Kenichi , Ichikawa Tomoaki 
Published: January 2020

Objective
To evaluate the effect of ultra high-resolution computed tomography (UHRCT) and model-based iterative reconstruction (MBIR) on the detectability of simulated submillimeter artery.

Methods
A small vessel phantom ranging from 0.4 to 2.0 mm in diameter and edge phantoms of low to high attenuation values were scanned by UHRCT (super-high-resolution mode and normal-resolution-mode) and conventional CT, and data were reconstructed by MBIR and filtered back projection (FBP). Vessel detectability was assessed subjectively and the effective size at which 50% of response was achieved (ES50 [mm]) was calculated. Modulation transfer function (MTF) was calculated by an edge spread function method.

Results
ES50 of super high-resolution mode (0.36 mm for MBIR and 0.50 mm for FBP) was significantly smaller than those of normal-resolution mode (P < 0.01). In the MTF analysis, the MTF of MBIR improved as the edge phantom attenuation increased, whereas that of FBP was stable.

Conclusions
Both UHRCT and MBIR are effective for the detectability of simulated submillimeter artery.
Quantitative Assessment of Extracellular Volume in Doxorubicin-Induced Liver Injury in Beagle Models by Equilibrium Computed Tomography
Authors: Han Pengxi , Zhou Zhen , Wang Rui , Wang Hui , Sun Zhonghua , Wang Ximing , Xu Lei 
Published: January 2020

Purpose
The purpose of this study was to determine whether liver extracellular volume (ECV) measured using equilibrium computed tomography (EQ-CT) can be used to quantitatively assess doxorubicin-induced liver injury (DILI).

Methods
The ethical approval was obtained from the Institutional Animal Care and Use Committee regulations. Thirteen dogs administered with doxorubicin for 0 to 24 weeks were imaged by contrast-enhanced EQ-CT. The dogs were divided into 3 groups: the baseline (13 dogs), 16-week (10 dogs), and 24-week (7 dogs) groups. Pathological analysis of the liver was performed using hematoxylin-eosin and Masson staining. Liver ECV uptake was calculated for each group and correlated with the histopathological and serological findings of hepatic fibrosis (hyaluronic acid and procollagen type III).

Results
In the baseline group, the median ECVs of the right and left liver lobes were 21.78% (interquartile range [IQR], 16.78%–26.68%) and 20.91% (IQR, 16.39%–24.07%), respectively. In the 16- and 24-week groups, the median ECVs of these 2 liver lobes were 28.18% (IQR, 20.56%–34.61%) and 25.96% (IQR, 14.07%–41.38%) and 29.71% (IQR, 27.19%–35.25%) and 29.22% (IQR, 22.62%–38.67%), respectively. There were no significant differences in ECV between the left and right lobes in the 3 groups (P < 0.05). Both the 16- and 24-week groups showed significantly higher ECV than did the primary group (P = 0.001–0.0006). However, there were no significant differences in ECV between the 16-week group and 24-week group (P = 0.412). There was a positive correlation between the serum index and edema due to the inflammation and necrosis associated with DILI (R
2 = 0.6534, R
2 = 0.7129).

Conclusions
Extracellular volume measured by EQ-CT imaging can accurately predict the potential DILI through the quantification of ECV changes.
Safety and Efficacy of Early Tube Removal Following Percutaneous Transhepatic Gallbladder Drainage: an Observational Study
Authors: Kamezaki Hidehiro , Tsuyuguchi Toshio , Shimura Kenji , Sakamoto Dai , Senoo Junichi , Mizumoto Hideaki , Kubota Michio , Yoshida Yu , Azemoto Ryosaku , Sugiyama Harutoshi , Kato Naoya 
Published: January 2020

Background:
There are currently no guidelines concerning the advisability and timing of tube removal following percutaneous transhepatic gallbladder drainage (PTGBD). The present study aimed to assess the feasibility and risks of early removal of the PTGBD tube under the scenario of subsiding inflammation, patent cystic and common bile ducts, and absence of intraperitoneal leakage.

Methods:
Patient background and outcomes were assessed retrospectively in 701 cases of acute cholecystitis treated with PTGBD. The median times until tube removal and tube dislodgement and the cumulative rates of tube dislodgement were calculated.

Results:
Tube removal was performed in 275 patients after a median time of 16 days (range: 6 to 213 d); biliary peritonitis was observed in 2 patients following tube removal. Tubes were removed in 8 and 35 patients within 7 and 10 days, respectively. Tube dislodgement was observed in 82 patients after a median time of 12 days (range: 1 to 125 d).

Conclusion:
The present study suggests that drainage tube removal is safe and effective when performed after a short drainage period of 7 to 10 days if the criteria for the removal of the drainage tube were met.