bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar
Authors: Herrera María Laura , Rubio Natalia Guisselle , Quintanilla Juan Pablo , Huerta Victor Manuel , Osorio-Forero Alejandro , Cárdenas Molano Melissa Andre , Corredor Páez Karen , Valderrama Mario , Cárdenas Fernando 
Published: January 2020

A pesar del amplio uso de la estimulación cerebral profunda para controlar patologías neurológicas y neuropsiquiátricas, su mecanismo de acción aún no es claramente conocido, y existen pocos estudios sistemáticos que relacionen la variación de parámetros de estimulación eléctrica (frecuencia, intensidad, duración del pulso) y la ejecución comportamental. La habénula es una estructura reguladora de respuestas emocionales diana en tratamientos para dolor crónico y depresión, pero la relación entre su estimulación crónica y el desempeño animal en pruebas conductuales no se ha establecido con claridad. Con el objetivo de evaluar el efecto emocional de la estimulación habenular crónica, en este estudio se utilizaron ratas Wistar que recibieron estimulación habenular a intensidad baja (10-80 µA) o alta (120-260 µA) y frecuencia baja (80-150 Hz) o alta (240- 380 Hz): BIBF-AIBF-BIAF-AIAF, durante 15 minutos a lo largo de tres días consecutivos. Al cuarto día, se hizo la evaluación en un laberinto elevado en cruz y en campo abierto. Los resultados indican un efecto de tipo ansiolítico en el tratamiento BIAF, en comparación con BIBF y AIBF (aumento del número de entradas, porcentaje de tiempo en brazos abiertos y de la distancia recorrida en ellos), efecto que no se explica por cambios en la locomotricidad (distancia recorrida en los brazos cerrados y la exploración en el campo abierto). Se concluye que el parámetro frecuencia posee mayor impacto sobre el efecto comportamental que la intensidad ?lo que puede explicar algunos hallazgos paradójicos previos?, que los parámetros utilizados no poseen efecto ansiogénico, y que los efectos potencialmente ansiogénicos de la estimulación a baja frecuencia y el papel de los sistemas dopaminérgicos y serotoninérgicos encontrados deben ser estudiados en futuras investigaciones.
El capital de la movilidad urbana cotidiana: Motilidad en la periferia de Lima Metropolitana
Authors: Regalado-Regalado Gerardo D. 
Published: January 2020

Resumen
Los procesos de movilidad urbana en las ciudades latinoamericanas se enfrentan a un territorio fragmentado, desigual, no inclusivo, que altera y fragmenta las condiciones espacio-temporales sobre las cuales se construye la espacialidad urbana de la vida cotidiana, y por ende afecta sus desplazamientos. Es por lo que se hace necesario estudiar las prácticas sociales de viajes y la relación directa con el capital de motilidad que ostenta un individuo y que le permite ejercer su habitus ambulante. En la zona periférica de Tahuantinsuyo en la ciudad de Lima (Perú), se aplicó un método etnográfico, de tipo micro-etnografía-particularista, combinando observación no participante y entrevistas semi-estructuradas, lo que permitió la recolección de datos cuantitativos y cualitativos para caracterizar la condición de accesibilidad, competencias, agencia y apropiación con el fin de determinar el capital de motilidad. Como resultado se determinó que este capital es alterado en función no solo a la posición socio-económica y la competencia con otros agentes, sino también, en relación a su grado de accesibilidad a su hábitat, sus capacidades físicas, habilidades o competencias, encontrando diversas y coincidentes prácticas sociales de viajes que alteran dicho capital.
Palabras clave: accesibilidad urbana; derecho a la ciudad; habitus ambulante; metropolización; producción del espacio; segregación urbana; sistemas de transporte;

AbstractThe processes of urban mobility in Latin American cities face a fragmented, unequal, non-inclusive territory that alters and fragments the spatio-temporal conditions on which the urban spatiality of everyday life is built, and therefore affects its displacements. That is why it is necessary to study the social travel practices and the direct relationship with the capital of motility that an individual has and that allows him to exercise his traveling habitus. In the peripheral area of ​​Tahuantinsuyo in the city of Lima (Peru), an ethnographic method was applied, of the micro-ethnography-particularist type, combining non-participant observation and semi-structured interviews, which allowed the collection of quantitative and qualitative data for characterize the condition of accessibility, competencies, agency and appropriation in order to determine the motility capital. As a result, it was determined that this capital is altered based not only on the socio-economic position and competition with other agents, but also, in relation to their degree of accessibility to their habitat, their physical abilities, skills or competencies, finding various and matching social travel practices that alter said capital.
Keywords: urban accessibility; right to the city; walking habitus; metropolization; space production; urban segregation; transportation systems;

Recibido: septiembre 9 / 2019 Evaluado: noviembre 29 / 2019 Aceptado: diciembre 13 / 2019
Publicado en línea: diciembre de 2019 Actualizado: diciembre de 2019
A simple extension of Rolle’s theorem and its relation with multiple internal rates of return (IRR)
Authors: Gómez Villarraga Fernando 
Published: January 2020

It has been stated a simple extension of the Rolle?s theorem. This extension permits to determine the amount of numbers in which in a given interval using the characteristics of the function in that interval. The extension has been proved and the geometric interpretation is presented. Illustrative examples have been developed for each of the cases that can be obtained by applying the extension. The relation of this theorem with the problem of multiple internal rates of return (IRR) is presented.
The selected premises for the reconfiguration of the disability model. The posthumanist perspective
Authors: ŻÓŁKOWSKA TERESA , KALISZEWSKA KAROLINA 
Published: January 2020

Teresa Żółkowska, Karolina Kaliszewska, The selected premises for the reconfigura-tion of the disability model. The posthu-manist perspective. Interdisciplinary Contexts of Special Pedagogy, no. 25, Poznań 2019. Pp. 55-81. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2019.25.03
In the contemporary special pedagogy, it is clearly seen, that we are dealing with a situation of passing over scholarly programmes that refer, i.a. to the medical and social model of disability. We remain in a inter-paradigmatic transition period, in which new views on disability are appearing. One of the most popular scholarly approaches is the posthumanism, the characteristics of which are, i.a.: the critique of humanism, the departure from anthropocentrism, the appearance of a new materialism, the direction of research towards objects, animals, as well as, the relations of people and non-people. The example of such posthumanist approach, that may constitute the context for the creation of new models of disability, is the Actor-Network theory developed by Bruno Latour and his associates.
Investigation of Biosensor Potential Component Stability Caused by Influence of External Condition
Authors: Kłos-Witkowska Aleksandra , Martsenyuk Vasyl 
Published: January 2020

Abstract
The analysis of UV-VIS spectrum was used for testing changes through 36 days and the impact of external conditions (reduced temperature (R), microwave radiation (M) and normal conditions (NC) for comparisons) on the stability of: BSA and BSA-Fe2+ complexes after different treating procedure. The increase of BSA absorption with increasing concentration of Fe2+ was observed. Increased absorption of BSA, and BSA-Fe2+ with time, related probably to conformational changes present in the protein and changes in electrostatic reactions within the BSA-Fe2+ complexes. Examination of the impact of an external factor on stabilization of the protein and complexes showed a tendency to keep the stability under reduced temperature and a trend with accelerated protein and complex aging under microwave radiation. The observed tendencies to changes under the influence of external factors became more significant in time. These effects were most probably related to changes of the protein structure and time, while the observed trend of accelerating the changes was impacted by the applied external factors.
Effect of Zinc Ammonium Acetate on Characteristics of Timothy Canopy and Seed Yield
Authors: Radkowski Adam , Radkowska Iwona , Lemek Tadeusz , Jakubowski Tomasz 
Published: January 2020

Abstract
The purpose of the experiment was to assess the effect of application of zinc ammonium acetate (ZAA) on yielding, morphological features and on selected vegetation indices of timothy cv. ‘Owacja’ cultivated for seeds. Zinc ammonium acetate that has a biostimulatory effect was used foliar in the carried out experiment. The experiment was conducted in the years 2015-2017 at the experimental station in Prusy near Krakow, a part of the Experimental Station of the Institute of Crop Production of the University of Agriculture in Krakow. The field experiment was set up in a randomized block design, in four replications, and the area of experimental plots was 10 m2. Degraded Chernozem formed from loess (classified to the first class quality soil) was present on the experimental area. The experiment consisted in applying ZAA as spray at three doses: 0.214, 0.267 and 0.400 kg(ZnNH4(CH3CO2)3)/ha. Based on the obtained preliminary results, it was found that application of foliar activator in a higher dose (0.400 kg/ha) caused a significant (p ≤ 0.05) increase in seed yield, 1000-seed weight and in germination capacity in relation to the control. Improvement in morphological properties was also observed. Leaf greenness index (SPAD) was also determined. Its highest value was found in plants from the treatment where the highest dose of the zinc ammonium acetate was applied. Seeds obtained from plants treated with ZAA were riper (ripeness was measured with 1000-seed weight) and had higher germination capacity in relation to control treatments.
Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
Authors: Kapelle Imanuel Berly Delvis , Manalu Wasmen , Souhoka Fensia Analda 
Published: January 2020

Abstract
The active component in cullilawan oil can be synthesized into curcumin analogue product, which has pharmacological activity. The synthesis process by using conventional and microwave methods can produce different isomer products. Different synthesis products and models of animal are used to provide different hepatoprotective effects. The aim of this study was to use the curcumin analogue synthetic products (AKS-k and AKS-m) from cullilawan oil in male mice (Mus musculus L.) liver damage treatment induced by carbon tetrachloride (CCl4). The in vivo method was employed using biochemical of blood and histopathological images of liver cells as indicators. The results showed that the curcumin analogue synthetic product using microwave methods had better pharmacological effects than the conventional method product in terms of the results of blood biochemical analysis and microscopic images of liver cells.
Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
Authors: Dwiputri Ayu Wulan , Pristianty Liza , Hermansyah Andi 
Published: January 2020

Abstract

Background
The growing burden of diabetes mellitus (DM) in Southeast Asia puts pharmacists in the ideal position to provide management of DM. This narrative review aims to describe the evidence of pharmacist contribution in improving DM in Southeast Asia.

Content
A literature search was conducted to identify relevant research articles published from 2010 to 2018 in four databases (Scopus, Pubmed, MEDLINE, and Springerlink) describing pharmacist roles and activities intended to improve management of DM in Southeast Asian countries. Results were synthesized narratively and divided into three main sections: (1) the role of pharmacist in DM management, (2) the impact of pharmacist role, and (3) the barriers to the implementation of services in DM management. A total of 16 studies were identified, of which ten studies mentioned services that were conducted exclusively by a pharmacist and the remaining collaborated with other health professionals. A number of pharmacist services were reported including prevention, dispensing, medication review, drug information services, patient counselling and education, monitoring, follow-up, and referral. Barriers related to individual, organizational, and public recognition were described.

Summary and outlook
The Pharmacist can contribute to improve DM management in a variety of settings. Action research on pharmacist intervention in DM is recommended.
A comparison of the effect of pressure on the KID21 (Youmen) and P6 (Neiguan) points on the severity of nausea and vomiting of pregnancy
Authors: Galeshi Mina , Ghanbarpour Azita , Naeimi Rad Mojgan , Asghari Shokat 
Published: January 2020

Abstract

Background
Nausea and vomiting of pregnancy (NVP) is the most common problem for women in early pregnancy. The present study was conducted to compare the effect of pressure on KID21 and P6 on the severity of NVP.

Methods
This single-blind clinical trial was conducted on pregnant women in their first trimester with NVP, referring to the clinic of Ayatollah Rouhani Hospital of Babol, Iran, in 2017. Eighty-two participants were randomly divided into KID21 and P6 pressure groups. The researcher applied pressure on these two points 20 min each day for four consecutive days. The severity of nausea and vomiting was then assessed using the visual analog scale (VAS) by the patient and counting its frequency in 24 h, respectively. Finally, the collected data were analyzed using SPSS 22 by repeated measures ANOVA and paired sample T-Test.

Results
The severity of NVP in the 82 participating pregnant women decreased in both groups (p<0.001), and there was no significant difference between the two groups in terms of the severity of NVP (p=0.68), although the reduction in nausea was greater in the P6 group than KID21 group, and the reduction in vomiting was greater in the KID21 group than the P6 group. Effect size for vomiting and nausea was 0.28 and 0.16, respectively. No side-effects were observed in the two groups during these four days.

Conclusions
Pressure on P6 and KID21 points has no advantage over each other in the treatment of NVP, but acupressure is an effective, complication-free, inexpensive and accessible treatment for this complication.
Shaped femtosecond laser induced photoreduction for highly controllable Au nanoparticles based on localized field enhancement and their SERS applications
Authors: Li Chen , Hu Jie , Jiang Lan , Xu Chenyang , Li Xiaowei , Gao Yunfeng , Qu Liangti 
Published: January 2020

Abstract
Gold nanoparticles (Au NPs) have a wide range of applications because of their localized surface plasmon resonance properties. Femtosecond laser is considered to be an effective method for preparing Au NPs because of its characteristics of ultrashort irradiation periods and ultrahigh intensities. In this study, a novel method is proposed to produce an Au NP-attached substrate using the spatially and temporally shaped femtosecond laser. Laser-induced periodic surface structures (LIPSS) are designed to obtain the localized optical field enhancement, which leads to the femtosecond laser spatially reshaping, enabling the deposition of Au NPs by photoreduction on silicon substrates. The Au NPs prepared by this method exhibit morphological controllability and chemical stability, especially excellent spatial selectivity and uniformity, resulting in the tunable and stable surface-enhanced Raman scattering (SERS) applications. Also, the temporally shaped femtosecond pulses are introduced to further increase the enhancement factors of the SERS. This method successfully achieves the controllable morphology synthesis and selective deposition of Au NPs on the substrate simultaneously, which provides a promising candidate for SERS substrates fabrication, and holds potential applications in optoelectronics, such as molecular detection and biosensors.
Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations
Authors: Yenenler Aslı , Gerlevik Umut , Sezerman Ugur 
Published: January 2020

Abstract

Objective
We identify the impacts of structural differences on functionality of EG3_S2 endoglucanase enzyme with MD studies. The results of previous experimental studies have been explained in details with computational approach. The objective of this study is to explain the functional differences between shuffled enzyme (EG3_S2) and its native counterpart (EG3_nat) from Trichoderma reseei, via Molecular Dynamics approach.

Materials and methods
For this purpose, we performed MD simulations along 30 ns at three different reaction temperatures collected as NpT ensemble, and then monitored the backbone motion, flexibilities of residues, and intramolecular interactions of EG3_S2 and EG3_nat enzymes.

Results
According to MD results, we conclude that EG3_S2 and EG3_nat enzymes have unique RMSD patterns, e.g. RMSD pattern of EG3_S2 is more dynamic than that of EG3_nat at all temperatures. In addition to this dynamicity, EG3_S2 establishes more salt bridge interactions than EG3_nat.

Conclusion
By taking these results into an account with the preservation of catalytic Glu residues in a proper manner, we explain the structural basis of differences between shuffled and native enzyme via molecular dynamic studies.
Investigation of the relationship cellular and physiological degeneration in the mandible with AQP1 and AQP3 membrane proteins
Authors: Çiçek Mustafa , Unsal Velid , Tümer Mehmet Kemal 
Published: January 2020

Abstract

Objective
In this study, we aimed to investigate the changes in the levels of oxidative stress and antioxidant enzymes on the mandibular bone caused by the expression of aquaporin-1 and aquaporin-3 proteins.

Material and method
14 Balb/C white mice were divided into two groups of seven, based on whether they are young or old. Mandibular tissue samples were taken for biochemical and histological analysis.

Results
Findings of our study has shown that, AQP-1 and AQP-3 immunoreactivity significantly decreased in mandibular bone tissues of aged mice in comparison to younger mice (p < 0.05). MDA and AOPP levels, which are the indicators of oxidative stress, increased in elderly mice and antioxidant defense system SOD enzyme activity was decreased (p < 0.05). The TNF-α cytokine level, which is the indicator for inflammations, was found to be higher in older mice than in young mice (p < 0.05).

Conclusion
As a result, it was observed that cellular damage, disruption in water – electrolyte balance and increased inflammation that occur during the natural process of aging had caused serious and irreversible disturbances.
Direct Comparison of Odor Responses of Homologous Glomeruli in the Medial and Lateral Maps of the Mouse Olfactory Bulb
Authors: Sato Tokiharu , Homma Ryota , Nagayama Shin 
Published: January 2020

AbstractOlfactory sensory neurons (OSNs) expressing same-type odorant receptors typically project to a pair of glomeruli in the medial and lateral sides of the olfactory bulbs (OBs) in rodents. This multiple glomerular representation of homologous inputs is considered to have more important functional roles for odor information processing than the redundant backup system. However, a consensus idea is lacking and this hinders interpretation of the phenomenon. In addition, the shared and unique odorant response properties of the homologous glomeruli remain unclear because the majority of medial glomeruli are hidden in the septal OB, and thus it is difficult to directly compare them. OSNs, which express trace amine-associated odorant receptors (TAARs), were recently identified that project to a pair of glomeruli uniquely located in the dorsal OB. In this study, we measured the odorant-induced calcium responses of homologous pairs of TAAR glomeruli simultaneously in anesthetized mice and directly compared their response patterns. We found that they exhibited similar temporal response patterns and could not find differences in onset latency, rise time, decay time, or response amplitude. However, the medial glomeruli had significantly larger respiration-locked calcium fluctuations than the lateral glomeruli. This trend was observed with/without odorant stimulation in postsynaptic neurons of GABAergic, dopaminergic, and mitral/tufted cells, but not in presynaptic olfactory sensory axon terminals. This indicates that, at least in these TAAR glomeruli, the medial rather than the lateral OB map enhances the respiration-locked rhythm and transfers this information to higher brain centers.
Reactivated Spatial Context Guides Episodic Recall
Authors: Herweg Nora A. , Sharan Ashwini D. , Sperling Michael R. , Brandt Armin , Schulze-Bonhage Andreas , Kahana Michael J. 
Published: January 2020

The medial temporal lobe (MTL) is known as the locus of spatial coding and episodic memory, but the interaction between these cognitive domains as well as the extent to which they rely on common neurophysiological mechanisms is poorly understood. Here, we use intracranial electroencephalography and a hybrid spatial-episodic memory task (29 subjects, 15 female) to determine how spatial information is dynamically reactivated in subregions of the human MTL and how this reactivation guides recall of episodic information. Our results implicate theta oscillations across the MTL as a common neurophysiological substrate for spatial coding in navigation and episodic recall. We further show that our index of retrieved spatial context is high in the hippocampus (HC) in an early time window preceding recall. Closer to recall, it decreases in the HC and increases in the parahippocampal gyrus. Finally, we demonstrate that hippocampal theta phase modulates parahippocampal gamma amplitude during retrieval of spatial context, suggesting a role for cross-frequency coupling in coding and transmitting retrieved spatial information.SIGNIFICANCE STATEMENTBy recording from the human medial temporal lobe (MTL) while subjects recall items experienced in a virtual environment, we establish a direct relation between the strength of theta activity during memory search and the extent to which memories are organized by their spatial locations. We thereby pinpoint a role for theta oscillations in accessing the “cognitive map” during episodic retrieval and further highlight the dynamic interplay of hippocampus and extrahippocampal MTL in representing retrieved spatial context. Our results provide an important step toward a unified theory of MTL function encompassing its role in spatial navigation and episodic memory.