bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fair value's effects on closed-end funds' discounts and premia: is level 3 the sole perpetrator?
Authors: Fortin Steve , Hammami Ahmad , Magnan Michel 
Published: February 2020

PurposeThis study examines the long-term link between fair valuation uncertainty and discounts/premia in closed-end funds. This study argues that, in exploring the close-end funds puzzle, prior research generally omits to consider the uncertainty surrounding the measurement of funds' financial disclosure, as reflected in the fair value hierarchy, when investment specialty differs across funds.Design/methodology/approachRegressions were employed to explore how the fair value hierarchy affects closed-end funds' discounts/premia when investment specialty differs. The authors also examine the effects pre- and post-2012 to explore if that relationship changes due to the additional disclosure requirements enacted at the end of 2011.FindingsThe authors find that the three levels of the fair value hierarchy have effects that vary according to a fund's specialty. For equity specialized funds, Level 3 significantly increases discounts and decreases premia, suggesting the impact of valuation uncertainty that underlies Level 3 estimates; this relationship disappears (decreases in severity) for premia (discount) experiencing funds post-2012. In contrast, Level 1 and Level 2 do not have any significant effect on discounts or premia except that post-2012, Level 2 begins to display discount decreasing effects. For bond specialized funds, no significant association was noted between premia and any of the fair value levels except that post-2012, Level 3 begins to display premium increasing effects. However, results are different for discounts. The authors note that Level 1 valuations significantly increase discounts, but only post-2012; Level 2 valuations significantly decrease discounts (pre- and post-2012), consistent with such estimates incorporating unique and relevant information; and Level 3 valuations do not have a significant effect on discounts.Originality/valueThe results of this study revisit prior evidence and indicate that results about the effects of fair value measurement and the closed-end funds' puzzle are sensitive to the period length being considered and the investment specialty of the fund. The authors also note that additional disclosure regarding Level 3 valuation inputs decreases market concern for valuation uncertainty and increases the liquidity benefits of investing in Level 3 carrying funds.
Creating performance through innovations influenced by knowledge sharing and absorption capacity at the Bali weaving industry association
Authors: Riana I. Gede 
Published: February 2020

PurposeThis study aims to create performance through innovation that is influenced by knowledge sharing and absorption in the Bali weaving industry.Design/methodology/approachThis study was conducted using quantitative and qualitative designs. Questionnaires were distributed, whose results were measured using a five-point Likert scale. The research population included 1,132 employees of ikat weaving industry. Samples were selected using Slovin formula, resulting in the minimum samples of 175 employees. WarpPLS was used to analyze the influences of variables mentioned in the study hypotheses.FindingsKnowledge gained from external resources is expected to complement the information available in the organization. Sharing knowledge will be more meaningful and effective in supporting innovation and the performance of diligent craftsmen. Although knowledge sharing does not significantly influence innovation improvement, knowledge sharing is still important to improve company performance through stakeholder understanding of the business in general and the business's detailed process. Leader creativity is an important dimension in obtaining and gathering various information from external resources because sharing knowledge has a significant influence on performance and innovation through absorption.Originality/valueThis study was conducted in Bali because it is in accordance with the objectives of this study. Research in Kelungkung Regency is considered to represent Bali because it has the highest number of ikat weaving craftsmen. Knowledge and learning new things must be maintained to increase employee knowledge, understanding of new knowledge from external sources and the performance of diligent craftsmen in Bali.
Digital disruptions and the elderly – strategic adoptions for marketers
Authors: Ghosh Munmun 
Published: February 2020

Purpose
The paper discusses the potential of digital influence and the need to integrate technology-based platforms in the lives of older adults.

Design/methodology/approach
The author adopted “age” as a construct and discussed how the elderly in our society are adapting to the changing landscape of digital disruption. The study also highlighted some opportunities for marketers to focus on.

Findings
The author discussed in detail the presence of the elderly in the digital platforms and the need of the marketers to target this age group to generate business.

Originality/value
The paper introduced the necessity to understand and explore the under-explored segment of older adults. The study also deliberated various ways through which the marketers can actually drive business focusing on this section by taking care of only their daily needs and optimally utilizing the untapped opportunities of these platforms.
Industry 4.0: reshaping the future of HR
Authors: Verma Anju , Bansal Monika , Verma Jyoti 
Published: February 2020

Purpose
This paper draws attention to the importance of Smart Human Resource Management (Smart HRM) practices in Industry 4.0. Human Capital is inevitable in the growth and development of the organization. Hence, it is germane that the companies align their HR processes with the ever-changing technological landscape to harness growth, productivity and create value. The paper illustrates the smart HR practices of Tech Mahindra and the benefits derived from them.

Design/methodology/approach
The paper illustrates the case of Tech Mahindra’s HR digitalization journey to transform HR processes in the era of Industry 4.0

Findings
Smart HR 4.0. implementation is vital to coping up with the challenges of Industry 4.0.. The transformation of HR processes in Tech Mahindra led to improved productivity, reduced cost, reduced manual work, smart workforce, retention of talent and competitive edge.

Originality/value
To match the pace of industry 4.0 and leverage its true benefit the companies should focus on automation of HR processes, make the workforce smarter and agile to drive efficiency, innovation, improve productivity, save cost and stay hyper-competitive. This paper offers insights on that how Tech Mahindra promoted the Industry 4.0 technologies in various HR functions to foster a climate of innovation, growth, and development, thereby facilitating the company to stay ahead of the curve.
Nitrogen fertiliser and establishment method affect growth, yield and nitrogen use efficiency of rice under alternate wetting and drying irrigation
Authors: Santiago‐Arenas Raquel , Fanshuri Buyung A. , Hadi Sholih N. , Ullah Hayat , Datta Avishek 
Published: February 2020

AbstractSustainable rice production through selection of best suitable cultivar, water‐efficient crop establishment method and optimum nitrogen (N) management practice is needed to feed the growing world population. Two polyhouse experiments were conducted to evaluate the response of rice to different rates and schedules of N application under different establishment methods subjected to alternate wetting and drying (AWD) irrigation. In the first experiment, the response of two rice cultivars (Pathumthani 1, RD57) under three establishment methods (transplanting [TP], wet direct seeding [WDS], dry direct seeding [DDS]) and five N rates (0 [N0], 30 [N30], 60 [N60], 90 [N90], 120 [N120] kg ha−1) was evaluated. The second experiment consisted of the same cultivars and establishment methods, but with four N application schedules (T1: 100% at basal; T2: 75% + 25% at basal and at active tillering, respectively; T3: 50% + 25% + 25% at basal, at active tillering and at panicle initiation, respectively; and T4: 25% + 25% + 25% + 25% each at basal, at active tillering, at panicle initiation and at early flowering or just before heading starts) applied at the rate of N60 kg ha−1. Plants were maintained under AWD irrigation (soil was saturated by applying water whenever soil water potential drops to −5 kPa during the implementation period) in both experiments. RD57 performed better than Pathumthani 1 having higher shoot dry matter, panicle number, grain yield, total N uptake and apparent N recovery efficiency. TP gave better response than WDS and DDS regardless of cultivars. Application of N120 resulted in better growth, yield and its components and total N uptake regardless of establishment methods and cultivars. Increasing N rate decreased N use efficiency (NUE). Scheduling the interval of N application to two or three times (T2 or T3) for RD57 and Pathumthani 1, respectively, provided overall better results, and could be recommended for the tested rice cultivars. An optimal N rate and selection of critical growth stages for N application would be very effective for maximising yield and NUE under the water‐saving cultivation technique of AWD irrigation.
Involvement of the epidermal growth factor receptor in IL‐13–mediated corticosteroid‐resistant airway inflammation
Authors: Davies Elizabeth R. , Perotin Jeanne‐Marie , Kelly Joanne F.C. , Djukanovic Ratko , Davies Donna E. , Haitchi Hans Michael ,   the U‐BIOPRED Study Group
Published: February 2020

AbstractBackgroundEffective treatment for severe asthma is a significant unmet need. While eosinophilic inflammation caused by type 2 cytokines is responsive to corticosteroid and biologic therapies, many severe asthmatics exhibit corticosteroid‐unresponsive mixed granulocytic inflammation.ObjectiveHere, we tested the hypothesis that the pro‐allergic cytokine, IL‐13, can drive both corticosteroid‐sensitive and corticosteroid‐resistant responses.ResultsBy integration of in vivo and in vitro models of IL‐13–driven inflammation, we identify a role for the epidermal growth factor receptor (EGFR/ERBB1) as a mediator of corticosteroid‐unresponsive inflammation and bronchial hyperresponsiveness driven by IL‐13. Topological data analysis using human epithelial transcriptomic data from the U‐BIOPRED cohort identified severe asthma groups with features consistent with the presence of IL‐13 and EGFR/ERBB activation, with involvement of distinct EGFR ligands. Our data suggest that IL–13 may play a dual role in severe asthma: on the one hand driving pathologic corticosteroid‐refractory mixed granulocytic inflammation, but on the other hand underpinning beneficial epithelial repair responses, which may confound responses in clinical trials. Conclusion and Clinical RelevanceDetailed dissection of those molecular pathways that are downstream of IL‐13 and utilize the ERBB receptor and ligand family to drive corticosteroid‐refractory inflammation should enhance the development of new treatments that target this sub‐phenotype(s) of severe asthma, where there is an unmet need.
Feature selection and classification using support vector machine and decision tree
Authors: Durgalakshmi B. , Vijayakumar V. 
Published: February 2020

AbstractBreast cancer is one of the human threats which cause morbidity and mortality worldwide. The death rate can be reduced by advanced diagnosis. The objective of this article is to select the reduced number of features the help in diagnosing breast cancer in Wisconsin Diagnostic Breast Cancer (WDBC). This proposed model depicts women who all have no cancer cells or in benign stage later develop into malignant (metastases). Due to the dynamic nature of the big data framework, the proposed method ensures high confidence and low execution time. Moreover, healthcare information growth chases an exponential pattern, and current database systems cannot adequately manage the massive amount of data. So, it is requisite to adopt the “big data” solution for healthcare information.
Web service composition on IoT reliability test based on cross entropy
Authors: Song Yang , Gong Yun‐Zhan 
Published: February 2020

AbstractWeb service has developed the managed IoT application to let connected devices easily and securely interact with cloud applications and other devices. As an important factor for web service, the reliability of web services refers to the probability of web service running success. For modeling web service composition, we should abstract the process of web service composition. Due to the diversity and complexity of web service composition, it is unlikely to do exhaustive testing. In order to improve the quality of web service composition test cases and find out which path leads to the greatest probability of service combination failure, heuristic test case generation method is adopted to obtain the optimal test path. First, the web service composition test is abstracted into the MDP model. The QoS of the web service composition is taken as the software test optimization goal, and the cross‐entropy strategy is used to optimize the test case. The experimental results show that the test profile given by the cross‐strategy is better than the random test strategy. Detect and exclude the same number of software defects. Cross‐entropy strategy can significantly reduce the number of test cases, reduce test costs, and improve defect detection efficiency.
Regeneration enhancers: A clue to reactivation of developmental genes
Authors: Suzuki Nanoka , Ochi Haruki 
Published: February 2020

AbstractDuring tissue and organ regeneration, cells initially detect damage and then alter nuclear transcription in favor of tissue/organ reconstruction. Until recently, studies of tissue regeneration have focused on the identification of relevant genes. These studies show that many developmental genes are reused during regeneration. Concurrently, comparative genomics studies have shown that the total number of genes does not vastly differ among vertebrate taxa. Moreover, functional analyses of developmental genes using various knockout/knockdown techniques demonstrated that the functions of these genes are conserved among vertebrates. Despite these data, the ability to regenerate damaged body parts varies widely between animals. Thus, it is important to determine how regenerative transcriptional programs are triggered and why animals with low regenerative potential fail to express developmental genes after injury. Recently, we discovered relevant enhancers and named them regeneration signal‐response enhancers (RSREs) after identifying their activation mechanisms in a Xenopus laevis transgenic system. In this review, we summarize recent studies of injury/regeneration‐associated enhancers and then discuss their mechanisms of activation.
The importance of hyperosmolarity in diabetic ketoacidosis
Authors: Blank S. P. , Blank R. M. , Ziegenfuss M. D. ,   Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) for the ANZICS CORE Committee
Published: February 2020

AbstractAimDiabetic ketoacidosis is a hyperglycaemic emergency that is often treated in intensive care units (ICUs) despite having a low mortality and good prognosis. Current risk stratification is based primarily on acidosis, but it has been suggested that hyperosmolarity may also be an important marker of increased severity. Our aim was to evaluate the relationship between raised serum osmolarity and adverse clinical outcomes in ICU admissions for ketoacidosis.MethodsRetrospective review of prospectively collected data for adult admissions with ketoacidosis in the Australian and New Zealand Intensive Care Society Adult Patient Database over a 15‐year period (2004–2018). Exclusions were readmissions and records with critical missing data. Serum hyperosmolarity was defined as > 320 mosm/l. The primary outcome was hospital mortality; secondary outcomes were ICU mortality and other adverse clinical events.ResultsSome 17 379 admissions were included in the study population. People with hyperosmolarity had fourfold increased mortality, a higher incidence of renal failure and need for mechanical ventilation, and prolonged ICU and hospital length of stay. The relationship with mortality remained highly significant even after adjusting for severity of acidosis, hospital type, year of admission, time to ICU, and a modified Australia and New Zealand Risk of Death propensity score.ConclusionsAlthough adults with ketoacidosis have a good prognosis overall, hyperosmolarity was independently associated with a significantly higher incidence of multiple adverse outcomes including mortality. Whether or not this is directly causal, it may have practical applications to improve risk stratification and identify individuals at risk of adverse outcomes.
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders
Authors: Teodoro T. , Koreki A. , Meppelink A. M. , Little S. , Nielsen G. , Macerollo A. , Ferreira J. J. , Pareés I. , Lang A. , Edwards M. J. 
Published: February 2020

Background and purposeContingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV.MethodsMotor performance and CNV were analysed during a pre‐cued choice reaction time task with varying cue validity. Twenty‐one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow‐up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non‐responders) and retested.ResultsAt baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients −0.47 (95% CI −1.94, 1.00) versus controls −2.59 (95% CI −4.46, −0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow‐up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non‐responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow‐up −1.95 (95% CI −3.49, −0.41) versus baseline −0.19 (95% CI −1.73, 1.35), P < 0.001], contrary to non‐responders [follow‐up −0.32 (95% CI −1.79, 1.14) versus baseline −0.72 (95% CI −2.19, 0.75), P = 0.381].ConclusionsClinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.
Antidiabetics, statins and the risk of amyotrophic lateral sclerosis
Authors: Mariosa D. , Kamel F. , Bellocco R. , Ronnevi L.‐O. , Almqvist C. , Larsson H. , Ye W. , Fang F. 
Published: February 2020

BackgroundMedications that are used for treatment of metabolic disorders have been suggested to be associated with the development of amyotrophic lateral sclerosis (ALS).MethodsTo examine the associations of antidiabetics and statins with the subsequent risk of ALS we conducted a population‐based nested case‐control study of 2475 Swedish residents diagnosed with ALS during July 2006 to December 2013 and 12 375 population controls (five for each ALS case). We extracted information on filled prescriptions of antidiabetics and statins for both cases and controls from the Swedish Prescribed Drug Register during the years before ALS diagnosis. Conditional logistic regression was used to calculate odds ratios (ORs) for the associations of these medications with ALS risk.ResultsPatients with ALS were less likely to have been prescribed with antidiabetics compared with controls [OR, 0.76; 95% confidence intervals (CI), 0.65–0.90]. Conversely, statins were not associated with ALS risk overall (OR, 1.08; 95% CI, 0.98–1.19), although a positive association was noted among women (OR, 1.28; 95% CI, 1.10–1.48). The latter association was mostly explained by ALS cases being more likely to have a first prescription of statins during the year before diagnosis compared with controls (OR, 2.54; 95% CI, 1.84–3.49).ConclusionsThe inverse association of antidiabetics with ALS is consistent with the previously reported inverse association between type 2 diabetes and ALS risk. The increase in prescription of statins during the year before ALS diagnosis deserves attention because it might reflect an acceleration of the course of ALS due to statin use.
Uncovering Multidimensional Poverty Experiences in Shaping Children’s Socioemotional Trajectories during the First 6 Years of Schooling
Authors: Zhang Liwei , Han Wen‐Jui 
Published: February 2020

The extant literature has attested to the importance of poverty on child well‐being generally using a unidimensional approach. Researchers have yet to establish solid evidence on how multiple dimensions of poverty (e.g., depth, volatility, and spells of exposure) might be associated with children’s socioemotional well‐being during their early school years. Building upon Bronfenbrenner’s bioecological systems theory, this study used latent class analysis to identify poverty patterns by incorporating multiple dimensions of poverty and investigated the relationship between multidimensional poverty patterns and children’s socioemotional trajectories from kindergarten through fifth grade. Using the Early Childhood Longitudinal Study, Kindergarten Class of 1998–1999 (ECLS‐K), a longitudinal dataset featuring a nationally representative cohort of children in the United States (N ≈ 20,090), the analysis identified seven poverty groups. Each group exhibited a unique poverty or economic pattern that incorporates the three poverty dimensions. Growth‐curve results indicate that multidimensional poverty patterns were significantly associated with externalizing and internalizing behaviors both at kindergarten and over time by fifth grade. Children with the acutest form of economic deprivation—extreme poverty, volatile income, and multiple spells of poverty exposure—were reported to have the worst outcomes. The significant variations in children’s socioemotional trajectories due to different poverty patterns highlight the importance of poverty reduction and prevention strategies corresponding to those patterns for optimal effect. This study suggests a focus not just on helping families exit poverty temporarily, but on improving their economic security as a way to nurture children’s socioemotional well‐being.
Application of a social media platform as a patient reminder in the treatment of Helicobacter pylori
Authors: Luo Miaomiao , Hao Yu , Tang Ming , Shi Mengzhen , He Fengjuan , Xie Yuanmao , Chen Weigang 
Published: February 2020

AbstractBackgroundTo investigate the effect of a social media platform for the treatment of Helicobacter pylori infection.Materials and MethodsWe enrolled 222 patients from October 2018 to June 2019, who required H pylori therapy. We used WeChat, a social media platform, as a patient reminder tool. They were randomly divided into the intervention and control groups (n = 111 per group) to compare and evaluate their disease awareness, medication adherence, incidence of adverse drug reactions, and H pylori eradication rate.ResultsPatients in the intervention group had significantly better disease‐related knowledge, medication adherence, and H pylori eradication rates than those in the control group (P < .05).ConclusionsUsing a social media platform may improve treatment rates of H pylori infection.