bluuebunny/crossref_metadata_2025_split huggingface dataset:
iTRAQ-based quantitative proteomic of tobacco (Nicotiana tabacum L.) identified major host proteins involved in photosystems throughout the aging process
Authors: He Conglian , Sun Shubin , Tang Yun , He Chenggang , Li Pengfei , Xu Tianyang , Zhao Gaokun , Zou Congming , Lin Zhonglong , Chen Yi 
Published: April 2020

Abstract
Background: Leaf senescence is one of the most common manifestations in plant senescence and has an important effect on plant photosynthesis. Delaying or shorten the senescence of tobacco leaves is one of the important approaches to improve tobacco breeding. However, the molecular regulatory mechanism of tobacco leaf senescence in response to photosynthesis is still poorly understood. To gain insights into the senescence of tobacco leaves, we integrated analyses including photosynthesis, organelle ultrastructure, and proteome of tobacco leaves during senescence.Results: The photosynthetic rate, intercellular CO2 concentration, stomatal conductance and transpiration rate showed a downward trend, and the stability of organelle decreased with the senescence of tobacco leaves. Isobaric Tag for Relative Absolute Quantitation (iTRAQ) and Parallel Reaction Monitoring (PRM) were used to analyze the proteins expressed in different periods that were estimate based on photosynthetic physiology and ultramicroscopic observations. A total of 321, 319, 223 diﬀerentially expressed proteins (DEPs) were identified from over maturity (OM) vs immature (IM), OM vs well maturity (WM) and WM vs IM, respectively, including 122/199, 124/195 and 125/98 up/down proteins, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the DEPs were significantly enriched in metabolic pathways, biosynthesis of secondary metabolites, microbial metabolism in diverse environments and starch and sucrose metabolism. In addition, the down-regulated proteins were also involved in metabolic pathways, such as carbon sequestration of photosynthetic organisms and photosynthesis. PRM analysis was performed and indicated that iTRAQ is highly reliable in the identification of major proteins involved in tobacco senescence.Conclusions: This study provided important technical references for screening of host photosynthetic proteins during tobacco leaves senescence and established a basis for scientifically understanding of the senescence mechanism of tobacco leaves.
Discordant Alzheimer's neurodegenerative biomarkers and their clinical outcomes in older adults without dementia
Authors: Guo Yu , Li Hong-Qi , Tan Lin , Chen Shi-Dong , Yang Yu-Xiang , Ma Ya-Hui , Zuo Chuan-Tao , Dong Qiang , Tan Lan , Yu Jin-Tai 
Published: April 2020

Abstract
Background: In 2018 ATN framework, Alzheimer's neurodegenerative biomarkers comprised cerebrospinal fluid (CSF) total tau, 18 F-fluorodeoxyglucose-positron emission tomography, and brain atrophy. Although these biomarkers could be used interchangeably, some cases had discordant neurodegenerative biomarkers. Our aim was to assess the clinical outcomes of having discordant Alzheimer's neurodegenerative biomarkers. Methods: A total of 721 non-demented individuals from the Alzheimer's Disease Neuroimaging Initiative database were included and then further categorized into concordant negative, discordant, and concordant positive groups. Demographic distributions of the groups were compared. Longitudinal changes in clinical outcomes and risk of conversion were assessed using linear mixed-effects models and multivariate Cox proportional hazard models, respectively. Results: Discordant group was intermediate to concordant-negative and concordant-positive groups in terms of APOE ε4 positivity, CSF amyloid-beta and phosphorylated tau. Compared with concordant-negative group, discordant group deteriorated faster in cognitive scores (Mini-Mental State Examination, the Clinical Dementia Rating Scale-Sum of Boxes, and the Functional Activities Questionnaire) and demonstrated greater rates of atrophy in brain structures (hippocampus, entorhinal cortex and whole brain), and concordant-positive group performed worse over time than discordant group. Moreover, the risk of cognitive progression increased from concordant-negative to discordant to concordant-positive. The longitudinal results were validated in A+T+, cognitively normal and mild cognitive impairment individuals, and were also validated by applying different cut-offs for neurodegenerative biomarkers. Conclusions: Discordant neurodegenerative status denotes a stage of cognitive function which is intermediate between concordant-negative and concordant-positive. Identification of discordant cases would provide insights into intervention and new therapy approaches, particularly in A+T+ individuals. Moreover, this work may be a complement to the ATN scheme.
El problema mente-cerebro: sus origenes cartesianos
Authors: Matínez Velasco Jesús 
Published: April 2020

RESUMENEl artículo plantea la visión cartesiana del problema mente/cerebro y hace ver cómo su concepción ontológica dualista (mecanicismo/mentalismo), presente en su concepción del hombre, y de la que han participado otros eminentes estudiosos del problema, debe ser superada desde los planteamientos actuales de la neurociencia. No es necesario postular en el hombre una fuerza especial para explicar determinados fenómenos cognitivos. Debería bastar la actividad cerebral para explicar cualquier actividad humana, incluida la activad cognitiva. La mentalidad no es separable del cerebro, aunque también es cierto que se pueden simular determinadas operaciones cognitivas en un artefacto mecánico.PALABRAS CLAVEDESCARTES – DUALISMO – NEUROCIENCIA – MENTE ABSTRACTThe article discusses the Cartesian view of the mind/brain problema and shows how its dualistic ontological conception (mechanicism/mentalism), framed within his notion of man, equally assumed by other eminent specialists, should be overcome from the current statements of neuroscience. It is not necessary to acknowledge in man a special power to explain some cognitive phenomena. The neural activity should be enough to explain any human activity, the cognitive one included. The mental process cannot be separated from the brain, although in fact some cognitive operations can be simulated by a mechanic device.KEYWORDSDESCARTES – DUALISM – NEUROSCIENCE – MIND
Pengaruh Subsidi Listrik Terhadap Konsumsi Rumah Tangga Di Indonesia Periode 2004-2017
Authors: Sugiartiningsih Sugiartiningsih 
Published: April 2020

Tujuan penelitian ini untuk mengetahui pengaruh subsidi listrik terhadap konsumsi rumah tangga di Indonesia periode 2004-2017. Metode penelitian yang digunakan adalah deskriptif kuantitatif dengan pemodelan regresi sederhana. Dari hasil pengolahan data diprediksi akan memperoleh hubungan yang searah atau positif antara kedua variabel tersebut. Hal ini sesuai dengan dasar berfikir mikroekonomi dimana subsidi listrik akan berdampak penurunan biaya produksi bagi produsen yang pada tahap selanjutnya akan meningkatkan daya saing penawaran produk Indonesia. Kemudian dari sisi makroekonomi kondisi tersebut akan mendorong meningkatkan daya beli sehingga nilai pendapatan nasional riil juga meningkat yang akhirnya menaikkan pula konsumsi rumah tangga di Indonesia.
Kata kunci: Subsidi, Pendapatan, Konsumsi Rumah Tangga
Laporan Perancangan Sistem Informasi Penyewaan Kaset VCD/DVD Pada Raisya Rental
Authors: Suryadi Andri 
Published: April 2020

Berkembangnya kegiatan ekonomi pada saat ini memicu kegiatan ekonomi di semua bidang. Di antara kegiatan ekonomi tersebut adalah kegiatan bisnis di bidang persewaan kaset VCD/DVD, sehingga pada saat ini banyak muncul usaha yang bergerak di bidang persewaan kaset VCD/DVD. Pemanfaatan sistem informasi berbasis komputer dapat membantu proses pengolahan data menjadi lebih cepat dan mudah. Berdasarkan hasil observasi dan wawancara yang dilakukan, diketahui bahwa pada Raisya Rental, semua sistem manajemennya dijalankan secara manual. Adapun kegiatan yang masih berjalan secara manual adalah pengentrian data penyewa dan identitas VCD/DVD, sehingga sering terjadi kesalahan maupun kehilangan data-data secara tidak sengaja, yang mengakibatkan para pemberi jasa mendapatkan kerugian yang cukup besar. Hal ini dapat diatasi dengan pemanfaatan sistem informasi berbasis komputer. Berdasarkan paparan yang telah disimpulkan diperlukan sebuah sistem informasi yang memanfaatkan komputer yang dapat menangani dan mengelola datadata yang berhubungan dengan pengentrian data penyewa dan identitas VCD/DVD. Untuk mendapat informasi yang baik dan akurat, maka diperlukan adanya sistem informasi yang mampu memenuhi kebutuhan pengelolaan data-data penyewaan pada Raisya Rental. Berdasarkan atas gambaran tersebut, maka penulis memilih judul Sistem Informasi Penyewaan Kaset Vcd/Dvd Pada Raisya Rental menggunakan metode prototype. Kata Kunci : Rental, VCD, Sistem Informasi, Prototype
Perancangan Sistem Informasi Manajemen Knowledge Berbasis WEB di Prodi Sistem Informasi Universitas Terbuka
Authors: Nurdiana Dian 
Published: April 2020

Abstract - Knowledge management is needed right now, but many companies or institutions are constrained in conducting knowledge management because of the limitations of the information system. In Information Systems Study Program Universitas Terbuka still uses a manual system that uses Windows file explorer. This results in the difficulty of sharing information with outsiders. Therefore we need a web-based knowledge management information system design that can solve problems so far. The design model in this article uses the Unified Modeling Language (UML) model, which is a structural model and techniques for modeling object-oriented program (OOP) design. The results of the design of knowledge management information systems are expected to be able to help develop software later. Keywords: information systems, knowledge management, Unified Modeling Language (UML). Abstrak - Knowledge manajemen merupakan hal yang dibutuhkan saat ini, namun banyak perusahaan atau lembaga terkendala dalam melakukan knowledge manajemen karena keterbatasan sistem informasi. Di Prodi Sistem Informasi Universitas Terbuka masih menggunakan sistem manual yaitu menggunakan windows file explorer. Hal ini mengakibatkan sulitnya berbagi informasi dengan pihak luar. Oleh sebab itu dibutuhkan sebuah perancangan sistem informasi manajemen knowledge berbasis web yang bisa menyelesaikan permasalahan selama ini. Model perancangan pada artikel ini menggunakan model Unified Modeling Language (UML) yaitu model struktur dan teknik untuk pemodelan desain program berorientasi objek (OOP). Hasil yang dari perancangan sistem informasi manajemen knowledge ini diharapkan bisa membatu pengembangan perangkat lunak nantinya. Kata Kunci: sistem informasi, manajemen knowledge, Unified Modeling Language (UML).
SIGNIFICANT INVESTIGATIONS OF SITUATION AND VERSIONS IN INVESTIGATION VIOLATION OF SAFETY RULES DURING WORKS WITH HIGH-RISK
Authors: Spasenko К. 
Published: April 2020

The article proposes a system of typical investigative versions in the process of investigating breaches of security rules when performing high-risk work. An investigator’s program of verification of the proposed versions has been opened.
Separate depending on the content of the above elements of group 3 of typical investigative situations of breaches of security rules at the initial stage of the investigation. In the first investigative situation, the fact and manner of breach of the security rules, as well as the person who committed the breach, was established, the notification of the offense was received in the procedure of scheduled inspection. In the second investigative situation — the fact and method of violation of the security rules is established, information on the identity of the offender — is missing, the notification of the offense was received in the procedure of accident investigation. In the third investigative situation — the fact and the identity of the breach of security rules is established, information about the method of breach of security rules — is not available, proceedings for breach of security rules are initiated on the basis of a statement of the victim or his relatives. This differentiation of situations is related to the peculiarities of the departmental investigation of security breaches.
Solution of nonaxisymmetric stationary problem of heat conductivity for polar-orthotropic ring plate of variable thickness with account of heat transfer with external environment
Authors: Korolevich Uladzimir V. 
Published: April 2020

The solution of the nonaxisymmetric stationary problem of the heat conductivity for profiled polar-orthotropic annular plates considering the heat exchange with external environment through the bases is presented. Thermophysical characteristics of the material of the plate are assumed to be temperature-independent. A constant temperature T1∗ is maintained on the inner contour of the ring plate and on the outer contour N equidistant point sources of heat with the same temperature T2∗ each are applied. Plate temperature is higher than ambient temperature T0 (T0 < T1∗ < T2∗). It is assumed that the temperature does not vary in thickness of a thin ring plate. The temperature values on the contours of the annular plate are given. There are no internal heat sources in the plate. The temperature distribution in such plates will be nonaxisymmetric. Analytical solutions of the stationary heat conductivity problem for the following anisotropic annular plates are presented: the plate of constant thickness, the back conical and the conical plate. The Volterra integral equation of the second kind corresponding to the given differential equation of the stationary heat conductivity for profiled anisotropic annular plates is written to obtain the solution in the general case. The kernels of the integral equation for anisotropic annular plates of power and exponential profiles are given explicitly. The solution of the integral equation is written by using the resolvent. It is indicated that due to the presence of irrational functions in the kernels of the integral equation it is necessary to apply numerical methods in the calculation of iterated kernels or numerically solve the Volterra integral equation of the second kind. A formula for the calculation of temperatures in anisotropic annular plates of an arbitrary profile is given.
PENGARUH PEMBIAYAAN MUDHARABAH, MUSYARAKAH, MURABAHAH, DAN IJARAH TERHADAP PROFITABILITAS 4 BANK UMUM SYARIAH PERIODE 2013-2016
Authors: Putra Purnama 
Published: April 2020

This research employ quantitative descriptive method aimed at testing the effects of Mudharabah, Musyarakah, Murabahah, and Ijarah Financings simultaneously and partially on the profitability of Sharia Banks in 2013-2016. This research uses secondary data taken from financial reports of Sharia Banks (Bank Umum Syariah/BUS) registered at the Bank of Indonesia. The data is analyzed using multiple linear regression. Four Sharia Banks were used as samples in this study which provide financial reports per three months. They are chosen using purposive sampling method. From the research result, it can be inferred that mudharabah financing does not have significant effect, musyarakah financing has significant negative effect, while murabahah and ijarah financings have significant positive effect by partially on profitability. Whereas simultaneously have positive significant to profitability.
Penelitian ini bertujuan untuk mengetahui pengaruh pembiayaan mudharabah, musyarakah, murabahah, dan ijarah terhadap profitabilitas Bank Umum Syariah yang terdaftar di Bank Indonesia Periode 2013-2016. Data yang digunakan adalah laporan keuangan Bank Umum Syariah (BUS) yang terdaftar di Bank Indonesia. Data dianalisis menggunakan regresi linear berganda. Sampel dalam penelitian ini sebanyak 4 Bank Umum Syariah, yang menyediakan laporan keuangan per triwulan. Sampel diambil menggunakan teknik pengambilan purposive sampling. Hasil dari penelitian ini menunjukkan secara parsial bahwa pembiayaan mudharabah tidak berpengaruh, pembiayaan musyarakah berpengaruh negatif signifikan, pembiayaan murabahah berpengaruh positif signifikan, pembiayaan ijarah berpengaruh positif signifikan terhadap profitabilitas ROE. Sedangkan secara simultan pembiayaan mudharabah, musyarakah, murabahah dan ijarah berpengaruh positif signifikan terhadap profitabilitas.
Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review
Authors: Gbinigie Kome , Frie Kerstin 
Published: April 2020

BackgroundOn the 11 March 2020, the World Health Organization (WHO) declared that COVID-19 was a pandemic. To date, there are no medical treatments for COVID-19 with proven effectiveness. Novel treatments and/or vaccines will take time to be developed and distributed to patients. In light of this, there has been growing interest in the use of existing medications, such as chloroquine (CQ) and hydroxychloroquine (HCQ), as potential treatments of this disease.AimTo establish the current evidence for the effectiveness of CQ and HCQ in treating COVID-19.Design & settingA rapid review of the literature was conducted.MethodElectronic searches in PubMed and Google Scholar were conducted on 21 March 2020. A further search was conducted in Google for relevant literature on 28 March 2020.ResultsThere is limited evidence of in vitro activity of CQ/HCQ against SARS-CoV-2. A number of in vivo clinical trials are underway. The empirical data available from two of these trials reveal conflicting results. Both trials are characterised by small numbers of participants (n= 30 andn= 36) and suffer methodological limitations. No medium or long-term follow-up data is available.ConclusionAt present, there is insufficient evidence to determine whether CQ/HCQ are safe and effective treatments for COVID-19. High quality, adequately powered randomised clinical trials in primary and secondary care settings are urgently required to guide policymakers and clinicians. These studies should report medium- and long-term follow-up results, and safety data.
JEJAK TUANTA SALAMAKA DAN TRADISI ZIARAH KUBUR SEBAGAI BENTUK BUDAYA SPRITUAL
Authors: SALEH NUR ALAM 
Published: April 2020

Penelitian ini membahas tentang keberadaan Makam Syekh Yusuf atau di kenal juga dengan Tuanta Salamaka di Lakiung Kelurahan Katangka Kabupaten Gowa yang sampai saat ini masih dapat dijumpai dan dikaitkan dengan kegiatan pariwisata, tanggapan-tanggapan dari kalangan masyarakat tentang keberadaan Makam Syekh Yusuf manakala dijadikan sebagai objek wisata budaya, serta apa pengaruhnya bagi masyarakat sekitar makam. Dimana penelitian ini di lakukan pada salah satu daerah yaitu di Kelurahan Katangka Kecamatan Sombaopu Kabupaten Gowa. Penelitian ini menggunakan jenis penelitian kualitatif dengan tipe deskriptif. Teknik pengumpulan data diperoleh dengan penelitian lapangan yang mencakup observasi, dokumentasi dan wawancara, Adapun teknik analisis data yaitu reduksi data, penyajian data dan penarikan kesimpulan. Kata Kunci : Makam, Syekh Yusuf, Budaya dan Pariwisata
Beninese vaccination clinic
Authors: Sun Linda 
Published: April 2020

This photo was taken in the village of Ladji, which is on the outskirts of Cotonou, the capital of Benin. At the time, I was a second year medical student volunteering at a local medical clinic. On every Wednesday morning, many Beninese babies, like this one, cry out of discomfort while receiving their monthly vaccinations. The photo shows a local clinic nurse administering the vaccination.
Profil Penguasaan Konsep Struktur Atom pada Siswa Kelas X MIPA SMA Negeri 4 Palangka Raya Tahun Ajaran 2018/2019
Authors: Tasya Yulita , Sadiana I Made , Asi Nopriawan Berkat 
Published: April 2020

Struktur atom merupakan salah satu materi pelajaran kimia yang diajarkan di SMA/MA. Materi ini dipelajari dikelas X SMA tentang perkembangan teori atom, partikel dasar penyusun atom, konfigurasi elektron, serta bilangan kuantum. Konsep ini merupakan konsep dasar ilmu kimia untuk memahami ikatan kimia. Penelitian ini bertujuan untuk mendeskripsikan profil penguasaan konsep Struktur Atom pada siswa kelas X SMA. Penelitian ini merupakan jenis penelitian deskriptif yang dilaksanakan di SMA Negeri 4 Palangka Raya dengan subjek penelitian adalah 30 siswa kelas X MIPA-1. Data yang digunakan pada penelitian ini berupa dokumen RPP guru kimia yang bersangkutan, data penguasaan konsep siswa yang didapat melalui tes uraian, dan data hasil wawancara siswa. Hasil penelitian menunjukkan 1) rata-rata sebesar 62,16% berada pada kategori sedang. 2) Siswa dapat menjelaskan perkembangan teori atom untuk menunjukkan kelebihan dan kekurangan masing-masing teori atom dengan rata-rata penguasaan konsep sebesar 68,75% dengan kategori sedang. 3) Siswa dapat menentukan partikel dasar (proton, elektron, dan neutron) suatu atom berdasarkan nomor atom dan nomor massa dengan rata-rata penguasaan konsep sebesar 61,47% dengan kategori sedang. 4) Siswa dapat mengklasifikasi unsur ke dalam isotop, isobar, dan isoton dengan rata-rata penguasaan konsep sebesar 88,88% dengan kategori tinggi. 5) Siswa dapat menentukan bilangan kuantum pada elektron terluar dari suatu unsur atau ion dengan rata-rata penguasaan konsep sebesar 21,04% dengan kategori rendah.
AMPERE polar cap boundaries
Authors: Burrell Angeline G. , Chisham Gareth , Milan Stephen E. , Kilcommons Liam , Chen Yun-Ju , Thomas Evan G. , Anderson Brian 
Published: April 2020

Abstract. The high-latitude atmosphere is a dynamic region with processes that respond to forcing from the Sun, magnetosphere, neutral atmosphere, and
ionosphere. Historically, the dominance of magnetosphere–ionosphere interactions has motivated upper atmospheric studies to use magnetic
coordinates when examining magnetosphere–ionosphere–thermosphere coupling processes. However, there are significant differences between the
dominant interactions within the polar cap, auroral oval, and equatorward of the auroral oval. Organising data relative to these boundaries has
been shown to improve climatological and statistical studies, but the process of doing so is complicated by the shifting nature of the auroral oval
and the difficulty in measuring its poleward and equatorward boundaries. This study presents a new set of open–closed magnetic field line boundaries (OCBs) obtained from Active Magnetosphere and Planetary Electrodynamics
Response Experiment (AMPERE) magnetic perturbation data. AMPERE observations of field-aligned currents (FACs) are used to determine the location of
the boundary between the Region 1 (R1) and Region 2 (R2) FAC systems. This current boundary is thought to typically lie a few degrees equatorward
of the OCB, making it a good candidate for obtaining OCB locations. The AMPERE R1–R2 boundaries are compared to the Defense Meteorological
Satellite Program Special Sensor J (DMSP SSJ) electron energy flux boundaries to test this hypothesis and determine the best estimate of the
systematic offset between the R1–R2 boundary and the OCB as a function of magnetic local time. These calibrated boundaries, as well as OCBs
obtained from the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) observations, are validated using simultaneous observations of the
convection reversal boundary measured by DMSP. The validation shows that the OCBs from IMAGE and AMPERE may be used together in statistical
studies, providing the basis of a long-term data set that can be used to separate observations originating inside and outside of the polar cap.