bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe hyponatremia with seizures and confirmed mild brain edema by hysteroscopic myomectomy: a case report
Authors: Okazaki Haruko , Miura Norikazu , Kashima Yuki , Miyashita Ryoichi , Oe Katsunori , Kawakami Keiko , Ishikawa Tetsuya , Masui Kenichi 
Published: October 2020

Abstract
Background
Hyponatremia can be developed during hysteroscopic surgery with electrolyte-free irrigation fluid. We experienced severe hyponatremia with postoperative seizures and confirmed mild brain edema.

Case presentation
A quadragenarian female patient underwent a 2-h hysteroscopic myomectomy with electrolyte-free fluid for uterine distension under general anesthesia. Plasma sodium level of 84.1 mmol/L 100 min after the start of surgery indicated excessive absorption of the irrigation fluid. Acute severe hyponatremia was diagnosed with significant edema in the conjunctiva, lip, and extremities. She was treated with a continuous infusion of hypertonic saline. However, seizures and cerebral edema developed 7 h later. The patient recovered without neurological deficits at postoperative day 2.

Conclusion
The electrolyte-free irrigation fluid can be absorbed rapidly during hysteroscopic surgery. Its interruption with hyponatremia should be considered against prolonged surgery. Especially under general anesthesia, caution should be exercised because the typical symptoms of hyponatremia such as nausea and confusion are blinded.
Influence of roadkill during breeding migration on the sex ratio of land crab (Sesarma haematoche)
Authors: Ryu Mi , Kim Jae Geun 
Published: October 2020

AbstractAdult land crabs generally live on land while their larvae live in the sea. In the case of Sesarma haematoche, female crabs migrate from land to sea to release the larvae at the high tide of syzygy night. Artificial structures along coastal areas are being obstacles for the migration of land crabs and causing synchronized roadkills on coastal roads during breeding migration. In this research, we compared the sex ratios of crab populations in coastal areas with coastal roads and uninhabited island areas with no road. The proportion of females in inland habitats with coastal roads was significantly smaller than island habitats. In particular, females are exposed to the risk of annually repeated roadkills, and the proportion of females decreases rapidly with their growth. If this tendency is general for land crab populations in the coastal areas with roads, significant road mortality of female land crabs during breeding migration can lead to severe population decline in coastal areas. Therefore, it is necessary to take an action to save land crabs crossing coastal roads.
Development and content validation of the Pediatric Oral Medicines Acceptability Questionnaires (P-OMAQ): patient-reported and caregiver-reported outcome measures
Authors: Turner-Bowker Diane M. , An Haack Kristina , Krohe Meaghan , Yaworsky Andrew , Vivas Norma , Kelly Masami , Chatterjee Godhuli , Chaston Emily , Mann Erin , Reaney Matthew 
Published: October 2020

Abstract
Background
Evolving regulatory guidelines recommend routine assessment of the acceptability of pediatric oral medicines throughout clinical development processes. However, such assessment is problematic owing to a lack of standard methods or criteria that define acceptability for children and their caregivers. This research aimed to identify the attributes of acceptability for targeted oral formulation types that are important to children, and to develop content-valid patient- and caregiver-reported outcome acceptability measures for use in the context of clinical drug development.

Methods
A concept-focused literature review and two advisory panel meetings involving researchers, clinicians, and measurement scientists were conducted to identify acceptability attributes that may be relevant to children taking targeted oral medicine formulations. The Pediatric Oral Medicines Acceptability Questionnaires (P-OMAQs), including patient (P-OMAQ-P) and caregiver (P-OMAQ-C) versions, were drafted to assess these attributes. Qualitative concept elicitation (CE) and cognitive debriefing (CD) patient and caregiver interviews were conducted to confirm key acceptability attribute concepts for measurement and to evaluate patient and caregiver ability to understand and respond to the questions.

Results
A full-text review of 40 articles identified 24 acceptability attributes that were categorized into 10 overarching domains and organized into a preliminary conceptual model. Feedback from the advisory panel refined the preliminary model. In total, 14 attributes were reported during the CE phase of the interviews (n = 23 pediatric patients, n = 13 caregivers); six attributes were included in the final model. The draft P-OMAQ was refined over four waves of CD interviews (n = 31 pediatric patients, n = 48 caregivers). The final version of the P-OMAQ-P is a 12-item questionnaire designed for young people aged 8–17 years. The P-OMAQ-C is a 19-item questionnaire designed for adult caregivers of young people aged 6 months to 17 years. There are two versions of each questionnaire: one with a 24-h recall period and one with a 7-day recall period. All items are answered on a 5-point numerical rating scale.

Conclusions
This research supports the content validity of the patient and caregiver versions of the P-OMAQ. Both questionnaires appropriately assess the acceptability of oral medicine formulations from the perspective of pediatric patients and their caregivers.
Biological control agents in the integrated nematode management of potato in Egypt
Authors: Abd-Elgawad Mahfouz M. M. 
Published: October 2020

Abstract
Background
Potato represents Egypt’s largest vegetable export crop. Many plant-parasitic nematodes (PPNs) are globally inflicting damage to potato plants. In Egypt, their economic significance considerably varies according to PPN distribution, population levels, and pathogenicity.

Main body
This review article highlights the biology, ecology, and economic value of the PPN control viewpoint. The integration of biological control agents (BCAs), as sound and safe potato production practice, with other phytosanitary measures to manage PPNs is presented for sustainable agriculture. A few cases of BCA integration with such other options as synergistic/additive PPN management measures to upgrade crop yields are reviewed. Yet, various attributes of BCAs should better be grasped so that they can fit in at the emerging and/or existing integrated management strategies of potato pests.

Conclusion
A few inexpensive biocontrol products, for PPNs control on potato, versus their corresponding costly chemical nematicides are gathered and listed for consideration. Hence, raising awareness of farmers for making these biologicals familiar and easy to use will promote their wider application while offering safe and increased potato yield.
Cross-cultural adaption and validation of the German version of the Mini-BESTest in individuals after stroke: an observational study
Authors: Cramer Elena , Weber Franziska , Faro Gilian , Klein Michael , Willeke Dennis , Hering Thomas , Zietz Dörte 
Published: October 2020

Abstract
Background
Postural control is a very important function in everyday life. However, assessing postural control with commonly used measurement instruments (MIs) is limited due to deficits in their psychometric properties. The Mini-Balance Evaluation Systems Test (Mini-BESTest) is a comprehensive and multidimensional MI for assessing postural control in persons with limited balance function, such as individuals after stroke. Despite the increasing use of the Mini-BESTest worldwide, no German version is available.

Research question
Is the German version of the Mini-BESTest (GVMBT) comprehensible and valid for measuring postural control in individuals after stroke?

Methods
The Mini-BESTest was translated and cross-culturally adapted, following established guidelines. It was pilot-tested with ten participants. This observational measurement and validation study was conducted at one point and included 50 participants with subacute and chronic stroke (mean age: 64.58 ± 13.34 years/ 34 men/ 16 women). Convergent validity was investigated using 1) the Berg Balance Scale (BBS) and 2) the Timed “Up & Go” (TUG). The MIs were evaluated for normal distribution with the calculation of skewness, kurtosis and Q-Q-Plots. Spearman correlation coefficients and Bland Altman analysis were used to examine the relationship between the MIs. The internal consistency was assessed using Cronbach’s alpha.

Results
Comprehension of the GVMBT was confirmed. The GVMBT correlated significantly with the BBS (rs = 0.93) and the TUG (rs = − 0.85). Bland Altman analysis revealed low absolute differences. The GVMBT demonstrated no significant floor or ceiling effects and showed excellent internal consistency (Cronbach’s α = 0.90).

Significance
The GVMBT has excellent validity and internal consistency. Due to this and its specific subcategories, the GVMBT is recommended for the use in research and clinical practice. Further psychometric properties should be evaluated.
Effect of COD:N ratio on biological nitrogen removal using full-scale step-feed in municipal wastewater treatment plants
Authors: Phanwilai Supaporn , Noophan Pongsak , Li Chi-Wang , Choo Kwang-Ho 
Published: October 2020

AbstractThis study investigated the effect of low and high chemical oxygen demand (COD):N ratios on biological nitrogen removal and microbial distributions in full-scale step-feed (SF) municipal wastewater treatment plants (WWTPs) in Thailand (SF1) and Taiwan (SF2). The SF1 WWTP had a low COD:N (4:1) ratio, a long solids retention time (SRT) (> 60 d), and low dissolved oxygen (DO) conditions (0.2 mg L− 1 in anoxic tank and 0.9 mg L− 1 in aerobic tank). The total nitrogen (TN) removal efficiency was 48%. The SF2 WWTP had a high COD:N (10:1) ratio, a short SRT (7 d), and high DO (0.6 mg L− 1 in anoxic tank and 1.8 mg L− 1 in aerobic tank). The TN removal efficiency was 61%. The nitrification and denitrification rates from these two plants were inadequate. Using a quantitative polymerase chain reaction (qPCR) technique, the populations of ammonium oxidizing bacteria (AOB) and ammonium oxidizing archaea were quantified. Measurement of ammonia monooxygenase (amoA) gene abundances identified these AOB: Nitrosomonas sp., Nitrosospira sp., Nitrosoccus sp. and Zoogloea sp. Higher amounts of the archaeal-amoA gene were found with long SRT, lower DO and COD:N ratios. Abundance of Nitrobacter sp. was slightly higher than Nitrospira sp. at the SF1, while abundance of Nitrobacter sp. was two orders of magnitude greater than Nitrospira sp. at the SF2. More denitrifying bacteria were of the nirS-type than the nirK-type, especially at higher COD:N ratio. Most bacteria belong to the phyla Acidobacteria, Actinobacteria Bacteroidetes, Chloroflexi, Proteobacteria. The results from this work showed that insufficient carbon sources at the SF1 and high DO concentration in anoxic tank of SF2 adversely affected nitrogen removal efficiencies. In further research work, advanced techniques on the next generation sequencing with different variable regions should be recommended in full-scale WWTPs.
Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking study
Authors: Durojaye Olanrewaju Ayodeji , Mushiana Talifhani , Uzoeto Henrietta Onyinye , Cosmas Samuel , Udowo Victor Malachy , Osotuyi Abayomi Gaius , Ibiang Glory Omini , Gonlepa Miapeh Kous 
Published: October 2020

Abstract
Background
The 2019-nCoV which is regarded as a novel coronavirus is a positive-sense single-stranded RNA virus. It is infectious to humans and is the cause of the ongoing coronavirus outbreak which has elicited an emergency in public health and a call for immediate international concern has been linked to it. The coronavirus main proteinase which is also known as the 3C-like protease (3CLpro) is a very important protein in all coronaviruses for the role it plays in the replication of the virus and the proteolytic processing of the viral polyproteins. The resultant cytotoxic effect which is a product of consistent viral replication and proteolytic processing of polyproteins can be greatly reduced through the inhibition of the viral main proteinase activities. This makes the 3C-like protease of the coronavirus a potential and promising target for therapeutic agents against the viral infection.

Results
This study describes the detailed computational process by which the 2019-nCoV main proteinase coding sequence was mapped out from the viral full genome, translated and the resultant amino acid sequence used in modeling the protein 3D structure. Comparative physiochemical studies were carried out on the resultant target protein and its template while selected HIV protease inhibitors were docked against the protein binding sites which contained no co-crystallized ligand.

Conclusion
In line with results from this study which has shown great consistency with other scientific findings on coronaviruses, we recommend the administration of the selected HIV protease inhibitors as first-line therapeutic agents for the treatment of the current coronavirus epidemic.
Depression in adolescence: a review
Authors: Beirão Diogo , Monte Helena , Amaral Marta , Longras Alice , Matos Carla , Villas-Boas Francisca 
Published: October 2020

Abstract
Background
Depression is a common mental health disease, especially in mid to late adolescence that, due to its particularities, is a challenge and requires an effective diagnosis. Primary care providers are often the first line of contact for adolescents, being crucial in identifying and managing this pathology. Besides, several entities also recommend screening for depression on this period. Thus, the main purpose of this article is to review the scientific data regarding screening, diagnosis and management of depression in adolescence, mainly on primary care settings.

Main body
Comprehension of the pathogenesis of depression in adolescents is a challenging task, with both environmental and genetic factors being associated to its development. Although there are some screening tests and diagnostic criteria, its clinical manifestations are wide, making its diagnosis a huge challenge. Besides, it can be mistakenly diagnosed with other psychiatric disorders, making necessary to roll-out several differential diagnoses. Treatment options can include psychotherapy (cognitive behavioural therapy and interpersonal therapy) and/or pharmacotherapy (mainly fluoxetine), depending on severity, associated risk factors and available resources. In any case, treatment must include psychoeducation, supportive approach and family involvement. Preventive programs play an important role not only in reducing the prevalence of this condition but also in improving the health of populations.

Conclusion
Depression in adolescence is a relevant condition to the medical community, due to its uncertain clinical course and underdiagnosis worldwide. General practitioners can provide early identification, treatment initiation and referral to mental health specialists when necessary.
Observational Study to Evaluate the Clinical Efficacy of Thermalytix for Detecting Breast Cancer in Symptomatic and Asymptomatic Women
Authors: Kakileti Siva Teja , Madhu Himanshu J. , Krishnan Lakshmi , Manjunath Geetha , Sampangi Sudhakar , Ramprakash H.V. 
Published: October 2020

PURPOSE To evaluate the sensitivity and specificity of Thermalytix, an artificial intelligence–based computer-aided diagnostics (CADx) engine, to detect breast malignancy by comparing the CADx output with the final diagnosis derived using standard screening modalities. METHODS This multisite observational study included 470 symptomatic and asymptomatic women who presented for a breast health checkup in two centers. Among them, 238 women had symptoms such as breast lump, nipple discharge, or breast pain, and the rest were asymptomatic. All participants underwent a Thermalytix test and one or more standard-of-care tests for breast cancer screening, as recommended by the radiologists. Results from Thermalytix and standard modalities were obtained independently in a blinded fashion for comparison. The ground truth used for analysis (normal or malignant) was the final impression of an expert clinician based on the symptoms and the available reports of standard modalities (mammography, ultrasonography, elastography, biopsy, fine-needle aspiration cytology, and so on). RESULTS For the 470 women, Thermalytix resulted in a sensitivity of 91.02% (symptomatic, 89.85%; asymptomatic, 100%) and specificity of 82.39% (symptomatic, 69.04%; asymptomatic, 92.41%) in detection of breast malignancy. Thermalytix showed an overall area under the curve (AUC) of 0.90, with an AUC of 0.82 for symptomatic and 0.98 for asymptomatic women. CONCLUSION High sensitivity and high AUC of Thermalytix in women of all age groups demonstrates the efficacy of the tool for breast cancer screening. Thermalytix, with its automated scoring and image annotations of potential malignancies and vascularity, can assist the clinician in better decision making and improve quality of care in an affordable and radiation-free manner. Thus, we believe Thermalytix is poised to be a promising modality for breast cancer screening.
Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
Authors: Bassey Iya Eze , Emodi Bukola Abosede , Akpan Uwem Okon , Iyakndue Idorenyin Francesca Akpan , Anakebe Edim Azubuike , Icha Bassey Edward , Efobi Henry Afamuefuna , Ntinya Akan Joshua , Udoh Alphonsus Ekpe 
Published: October 2020

PURPOSEProstate cancer (CaP) incidence and mortality rate are increasing in Africa. Some have linked oxidative stress with the pathogenesis of cancer. This study assessed the levels of malondialdehyde (MDA), nitric oxide (NO), total plasma peroxide (TPP), and total antioxidant capacity (TAC) in Nigerian patients with CaP.PATIENTS AND METHODSOne hundred twenty patients with CaP and 100 apparently healthy controls were consecutively recruited into this case-control study. The patients with CaP were divided into treatment-naïve and androgen deprivation therapy (ADT)–treated groups. Anthropometric indices were measured, and MDA, NO, TAC, and TPP were assayed by colorimetric methods. The t test and analysis of variance were used in analysis of data; statistical significance was set at P < .05, and 95% CIs were reported.RESULTSThe patients with CaP had significantly higher waist-hip ratios and NO ( P = .0001), TPP ( P = .001), oxidative stress index (OSI; P = .003), and MDA values ( P = .002) than controls. The treatment-naive patients with CaP had significantly higher waist-hip ratios ( P = .011) and TPP ( P = .013), MDA ( P = .011), and NO values ( P = .0001) and lower TAC values ( P = .013) compared with the controls. The ADT-treated patients had higher waist-hip ratios ( P = .0001) and TPP ( P = .005), OSI ( P = .005), MDA ( P = .011), and NO values ( P = .0001) than the controls. However, the treatment-naive patients had significantly higher NO values ( P = .05) only compared with the ADT-treated patients. There was a significantly positive correlation between MDA and duration of treatment ( r = 0.280, P = .018) in ADT-treated patients with CaP.CONCLUSIONThis study demonstrated that patients with CaP have higher levels of TPP, MDA, and NO and lower levels of TAC compared with men without CaP. In addition, even in patients with CaP undergoing treatment, TPP and MDA levels remained high.
Cardiovascular risk assessment in South and Middle-East Asians living in the Western countries
Authors: Saeed Sahrai , Kanaya Alka M , Bennet Louise , Nilsson Peter M 
Published: October 2020

Nearly a quarter of the world population lives in the South Asian region (India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, and the Maldives). Due to rapid demographic and epidemiological transition in these countries, the burden of non-communicable diseases is growing, which is a serious public health concern. Particularly, the prevalence of pre-diabetes, diabetes and atherosclerotic cardiovascular disease (CVD) is increasing. South Asians living in the West have also substantially higher risk of CVD and mortality compared with white Europeans and Americans. Further, as a result of global displacement over the past three decades, Middle-Eastern immigrants now represent the largest group of non-European immigrants in Northern Europe. This vulnerable population has been less studied. Hence, the aim of the present review was to address cardiovascular risk assessment in South Asians (primarily people from India, Pakistan and Bangladesh), and Middle-East Asians living in Western countries compared with whites (Caucasians) and present results from some major intervention studies. A systematic search was conducted in PubMed to identify major cardiovascular health studies of South Asian and Middle-Eastern populations living in the West, relevant for this review. Results indicated an increased risk of CVD. In conclusion, both South Asian and Middle-Eastern populations living in the West carry significantly higher risk of diabetes and CVD compared with native white Europeans. Lifestyle interventions have been shown to have beneficial effects in terms of reduction in the risk of diabetes by increasing insulin sensitivity, weight loss as well as better glycemic and lipid control.
doi: https://doi.org/10.12669/pjms.36.7.3292
How to cite this:Saeed S, Kanaya AM, Bennet L, Nilsson PM. Cardiovascular risk assessment in South and Middle-East Asians living in the Western countries. Pak J Med Sci. 2020;36(7):1719-1725. doi: https://doi.org/10.12669/pjms.36.7.3292
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.