bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline tear fluid CGRP is elevated in active cluster headache patients as long as they have not taken attack abortive medication
Authors: Kamm Katharina , Straube Andreas , Ruscheweyh Ruth 
Published: August 2020

Background Calcitonin gene-related peptide plays a key role in cluster headache pathophysiology. It is released from the trigeminal nerve, which also innervates the eye. In this study, we tested if tear fluid calcitonin gene-related peptide measurement detects elevated calcitonin gene-related peptide levels in cluster headache patients compared to controls. Methods Calcitonin gene-related peptide concentration in tear fluid and plasma of 16 active episodic and 11 chronic cluster headache patients (all outside acute attacks) and 60 controls were assessed using ELISA. Results Cluster headache patients without use of attack abortive medication in the last 48 h showed significantly elevated tear fluid calcitonin gene-related peptide levels (1.78 ± 1.57 ng/ml, n = 17) compared to healthy controls (0.79 ± 0.74 ng/ml, p = 0.003) and compared to cluster headache patients who had used attack abortive medication in the last 48 h (0.84 ± 1.40 ng/ml, n = 10, p = 0.022). High calcitonin gene-related peptide levels in cluster headache patients were independent of the occurrence of a cluster headache attack in the last 48 hours (no attack: 1.95 ± 1.65 ng/ml, n = 8; attack: 1.63 ± 1.59 ng/ml, n = 9, p = 0.82) as long as no acute medication was used. No significant difference in tear fluid calcitonin gene-related peptide levels between episodic (1.48 ± 1.34 ng/ml) and chronic cluster headache patients (2.21 ± 1.88 ng/ml, p = 0.364) was detected. In contrast to these results in tear fluid, there were no significant group differences in plasma calcitonin gene-related peptide levels. Conclusion This study shows that active cluster headache patients have increased calcitonin gene-related peptide levels in tear fluid compared to healthy subjects, which are reduced to control levels after intake of attack abortive medication. Calcitonin gene-related peptide measurement in tear fluid is non-invasive, and has the advantage of allowing direct access to calcitonin gene-related peptide released from the trigeminal nerve.
Brain volume changes in spontaneous intracranial hypotension: Revisiting the Monro-Kellie doctrine
Authors: Wu Jr-Wei , Wang Yen-Feng , Hseu Shu-Shya , Chen Shu-Ting , Chen Yung-Lin , Wu Yu-Te , Chen Shih-Pin , Lirng Jiing-Feng , Wang Shuu-Jiun 
Published: August 2020

Objectives In the application of the Monro-Kellie doctrine in spontaneous intracranial hypotension, the brain tissue volume is generally considered as a fixed constant. Traditionally, cerebral venous dilation is thought to compensate for decreased cerebrospinal fluid. However, whether brain tissue volume is invariable has not yet been explored. The objective of this study is to evaluate whether brain tissue volume is fixed or variable in spontaneous intracranial hypotension patients using automatic quantitative methods. Methods This retrospective and longitudinal study analyzed spontaneous intracranial hypotension patients between 1 January 2007 and 31 July 2015. Voxel-based morphometry was used to examine brain volume changes during and after the resolution of spontaneous intracranial hypotension. Brain structure volume was analyzed using Statistical Parametric Mapping version 12 and FMRIB Software Library v6.0. Post-treatment neuroimages were used as surrogate baseline measures. Results Forty-four patients with spontaneous intracranial hypotension were analyzed (mean [standard deviation] age, 37.8 [8.5] years; 32 female and 12 male). The whole brain tissue volume was decreased during spontaneous intracranial hypotension compared to follow-up (1180.3 [103.5] mL vs. 1190.4 [93.1] mL, difference: −10.1 mL [95% confidence interval: −18.4 to −1.8 mL], p = 0.019). In addition, ventricular cerebrospinal fluid volume was decreased during spontaneous intracranial hypotension compared to follow-up (15.8 [6.1] mL vs. 18.9 [6.9] mL, difference: −3.2 mL [95% confidence interval: −4.5 to −1.8 mL], p < 0.001). Longer anterior epidural cerebrospinal fluid collections, as measured by number of vertebral segments, were associated with greater reduction of ventricular cerebrospinal fluid volume (Pearson’s r = −0.32, p = 0.036). Conclusion The current study found the brain tissue volume and ventricular cerebrospinal fluid are decreased in spontaneous intracranial hypotension patients. The change in ventricular cerebrospinal fluid volume, but not brain tissue volume change, was associated with the severity of spinal cerebrospinal fluid leakage. These results challenge the assumption that brain tissue volume is a fixed constant.
The Effect of Boarding on Obesity Among Middle School Students: Evidence From China
Authors: Yu Linyue , Chen Wei 
Published: August 2020

Purpose: This paper examines the effect of boarding on obesity among middle school students at boarding schools. Design: Quantitative, cross-sectional study. Setting: Data from the China Education Panel Survey (CEPS) were analyzed. The CEPS samples middle school students from 7th grade to 9th grade in China. Subjects: The final sample included 3,892 observations of boarding school students. Measures: Measures included body mass index (BMI) that determined obesity, boarding status, demographic information, and instruments for boarding status. Analysis: The instrumental variables approach based on the 2 stage least squares (2SLS) methodology was utilized. The endogenous models and the extended probit models were also applied to the data to confirm the robustness of the results. Results: Boarding has a significant negative effect on obesity for middle school boys but a smaller negative effect on obesity for middle school girls. Boarding was estimated to reduce obesity by roughly 14% (p < 0.01) among middle school boys and 6% (p > 0.1) among middle school girls. The overall estimated effect based on the pooled sample was about 10% (p < 0.01). Conclusion: School or government policies that encourage boarding at school can reduce obesity among middle school students, at least for middle school boys. Boarding at school can be a positive factor in preventing and controlling obesity among middle school students.
Maternal Transfer of Cetirizine Into Human Milk
Authors: Wilkerson Hannah , Datta Palika , Rewers-Felkins Kathleen , Baker Teresa , Hale Thomas W. 
Published: August 2020

Introduction Cetirizine hydrochloride is a second-generation H1 histamine antagonist with Food and Drug Administration approval for treatment of allergic rhinitis and urticaria. Currently, the Food and Drug Administration does not recommend use of cetirizine during breastfeeding, as there are insufficient studies on both the transference of cetirizine into human milk and the effects of cetirizine in infants. Main issue To determine the concentration of cetirizine in human milk, samples were analyzed using high performance liquid chromatography mass spectrometry. Management Based on calculations, relative infant dose was found to be 1.77% at 24 hr. In addition, there were no reported adverse effects seen in the infants. Conclusion We suggest that transfer of cetirizine into human milk is minimal and unlikely to pose a significant risk to the breastfeeding infant. This is the first report presenting the transfer of cetirizine in human milk.
Factors affecting patient adherence to lung cancer screening: A multisite analysis
Authors: Stowell Justin T , Narayan Anand K , Wang Gary X , Fintelmann Florian J , Flores Efren J , Sharma Amita , Petranovic Milena , Shepard Jo-Anne O , Little Brent P 
Published: August 2020

Objective To identify factors associated with delayed adherence to follow-up in lung cancer screening. Methods Utilizing a data warehouse and lung cancer screening registry, variables were collected from a referred sample of 3110 unique participants with follow-up CT during the study period (1 January 2016 to 17 October 2018). Adherence was defined as undergoing chest CT within 90 days and 30 days of the recommended time for follow-up and was determined using proportions and multiple variable logistic regression models across the American College of Radiology Lung Imaging Reporting and Data System (Lung-RADS®) categories. Results Of 1954 lung cancer screening participants (51.9% (1014/1954) males, 48.1% (940/1954) female; mean age 65.7 (range 45–87), smoking history median 40 pack-years, 60.2% and 44.5% did not follow-up within 30 and 90 days, respectively. Participants receiving Lung-RADS® category 1 or 2 presented later than those with Lung-RADS® category 3 at 90 days (coefficient −27.24, 95% CI −51.31, −3.16, p = 0.027). Participants with Lung-RADS® category 1 presented later than those with Lung-RADS® category 2 at both 90- and 30-days past due (OR 0.76 95% CI [0.59–0.97], p = 0.029 and OR 0.63 95% CI [0.48–0.83], p = 0.001, respectively). Conclusions Adherence to follow-up was higher among participants receiving more suspicious Lung-RADS® results at index screening CT and among those who had undergone more non-lung cancer screening imaging examinations prior to index lung cancer screening CT. These observations may inform strategies aimed at prospectively identifying participants at risk for delayed or nonadherence to prevent potential morbidity and mortality from incident lung cancers.
Spirituality, Quality of Life, and End of Life Among Indigenous Peoples: A Scoping Review
Authors: Terpstra Jodi , Lehto Rebecca , Wyatt Gwen 
Published: August 2020

Introduction: While spirituality and quality of life (QOL) are essential components of end-of-life (EOL) care, limited studies have examined these constructs for indigenous peoples. Therefore, the purpose of this article was to examine the state of the science regarding spirituality and QOL at EOL for indigenous people, particularly Native Americans. Method: The Arksey and O’Malley (2005) framework guided this scoping review, which examined 30 articles that included qualitative and quantitative studies, commentary papers, and reviews. Results: The findings identified five spiritual dimensions: the life and death journey, a belief in spirits, tribally grounded traditions, dominant cultural religion influences, and a family focus. QOL indicators included survivorship, optimization of holistic health, communication, and access to appropriate resources. Death rituals were important EOL elements. Discussion: Given the importance of spirituality to QOL for indigenous people, clinicians must be knowledgeable and responsive to indigenous spiritual needs to promote QOL at EOL.
Impact of a Multidisciplinary Craniofacial Clinic for Patients With Craniofacial Syndromes on Patient Satisfaction and Outcome
Authors: Hoffman Caitlin , Yuan Melissa , Boyke Andre , Perera Imali , Rabbin-Birnbaum Corinne , O’Connor Ashley , Souweidane Mark , Imahiyerobo Thomas 
Published: August 2020

Objective: Multidisciplinary clinics are becoming widely utilized. Given the number of patients with craniofacial syndromes evaluated at our institution, and the burden of assessment by multiple subspecialists, we created an American Cleft Palate-Craniofacial Association–certified Craniofacial Multidisciplinary Clinic (CMC) composed of a nurse practitioner, neurosurgeon, plastic surgeon, otolaryngologist, oromaxillofacial surgeon, geneticist, pulmonologist, occupational therapist, dentist, and child life specialist to improve patient experience, lessen the burden of assessment, decrease time to surgery, and improve patients’ understanding of the diagnosis and treatment plan specifically for patients with complex craniofacial syndromes. We reviewed the impact of this clinic after 1 year of implementation. Design: Retrospective review was performed to identify patients with craniofacial syndromic diagnoses seen by the neurosurgery department before and after implementation of the CMC from February 2017 to present. Setting: The CMC is an outpatient clinic based in a tertiary care academic institution. Patients: Chart review was performed to identify demographic, diagnostic, clinical, and treatment data. We assessed clinic experience, and the impact on quality of clinical and surgical care was assessed via survey. We compared this cohort to patients with similar craniofacial syndromes treated prior to the CMC. Thirty patients seen at the CMC were identified, and data from a comparable cohort of 30 patients seen prior to the clinic’s inception was reviewed. Results: Our CMC survey response rate was 67% (n = 20/30) for the CMC patients. Second opinions sought by parents prior to CMC was higher (mean = 0.85, range: 0-3) than for patients seen at the CMC (mean = 0.16, range: 0-1). Mean time to surgery before the CMC was 10.1 months (range: 1-15) compared to 4 months (range: 3-5) after implementation. Parents agreed that they felt well-informed about their diagnosis (n = 18/20, 90%), and that the presence of a plastic surgeon (19/20, 95%) and a nurse practitioner (17/20, 85%) were valuable in coordination of their care. Following surgery, 76% (n = 13/17) of patients who received surgery were happy with the outcome, 76% (n = 13/17) were happy with the appearance of the scar, and 95% (n = 19/20) would recommend the CMC to others. Conclusion: Multidisciplinary evaluation of patients with complex craniofacial conditions provides comprehensive, efficient, and effective care, as well as improved parent satisfaction and knowledge base.
Indications for Deltoid and Spring Ligament Reconstruction in Progressive Collapsing Foot Deformity
Authors: Deland Jonathan T. , Ellis Scott J. , Day Jonathan , de Cesar Netto Cesar , Hintermann Beat , Myerson Mark S. , Sangeorzan Bruce J. , Schon Lew C. , Thordarson David B. , Johnson Jeffrey E. 
Published: August 2020

Recommendation: There is evidence supporting medial soft tissue reconstruction, such as spring and deltoid ligament reconstructions, in the treatment of severe progressive collapsing foot deformity (PCFD). We recommend spring ligament reconstruction to be considered in addition to lateral column lengthening or subtalar fusion at the initial operation when those procedures have given at least 50% correction but inadequate correction of the severe flexible subluxation of the talonavicular and subtalar joints. We also recommend combined flatfoot reconstruction and deltoid reconstruction be considered as a joint sparing alternative in the presence of PCFD with valgus deformity of the ankle joint if there is 50% or more of the lateral joint space remaining. Level of Evidence: Level V, expert opinion.
High-voltage synthetic inductor for vibration damping in resonant piezoelectric shunt
Authors: Dekemele Kevin , Van Torre Patrick , Loccufier Mia 
Published: August 2020

Resonant piezoelectric shunts are a well-established way to reduce vibrations of mechanical systems suffering from resonant condition. The vibration energy is transferred to the electrical domain through the bonded piezoelectric material where it is dissipated in the shunt. Typically, electrical and mechanical resonance frequencies are several orders apart. As such, finding a suitable high inductance component for the resonant shunt is not feasible. Therefore, these high inductance values are mimicked through synthetic impedances, consisting of operational amplifiers and passive components. A downside of these synthetic impedances is that standard operational amplifiers can only handle up to 30 V peak to peak and the state-of-the-art amplifiers up to 100 Vpp. However, as mechanical structures tend to become lighter and more flexible, the order induced voltages over the piezoelectric material electrode voltages increase above these limitations. In this research, a high-voltage synthetic inductor is proposed and built by combining the bridge amplifier configuration and the output voltage boost configuration around a single operational amplifier gyrator circuit, effectively quadrupling the range of the synthetic inductor to 400 Vpp. The impedance of the circuit over a frequency range is numerically and experimentally investigated. The synthetic inductor is then connected to a piezoelectric material bonded to a cantilever beam. Numerical and experimental investigation confirms the high-voltage operation of the implemented circuit and its suitability as a vibration damping circuit.
Transradial access for arteriovenous fistuloplasty in Singapore
Authors: Ong Chee Wui , Yong Enming , Hong Qiantai , Chandrasekar Sadhana , Quek Lawrence Han Hwee , Pua Uei , Tan Glenn Wei Leong , Lo Zhiwen Joseph 
Published: August 2020

Background: Endovascular balloon angioplasty is standard therapy for dysfunctional arteriovenous fistula in end-stage renal failure patients on hemodialysis. Venous antegrade or retrograde puncture of the fistula is typically performed to gain access for fistuloplasty. Transradial approach for brachiocephalic or brachiobasilic arteriovenous fistulas offers an alternative method of access with the advantage of addressing multi-focal juxta-anastomotic and venous stenosis from the same approach. We aim to review the efficacy, outcomes and complication rates of transradial access for arteriovenous fistuloplasty among patients in Singapore. Methods: A retrospective review of 195 endovascular fistuloplasties from September 2017 to August 2019, at a tertiary university hospital Vascular Surgery unit. Results: Of 195 fistuloplasties, 43 (22%) were transradial approach (23 brachiocephalic arteriovenous fistulas, 20 brachiobasilic arteriovenous fistulas) in 33 patients (67% male and mean age = 65 years). Of these 43 procedures, 11 (26%) were performed as balloon-assisted maturation fistuloplasties while 32 (74%) were performed for mature arteriovenous fistulas with multi-focal juxta-anastomosis and venous stenosis. Technical success rate was 95% with mean procedure duration at 43.5 ± 14.6 min. Mean pre- and post-fistuloplasty dialysis access flow rates increased from 502 to 952 ml/min (p < 0.001). Post-intervention primary patency was 100%, 66% and 20% at 1, 6 and 12 months, respectively. There were four patients with non-limb-threatening radial artery thrombosis (9.3%) while there was no radial artery pseudoaneurysm or post-procedural bleeding. Conclusion: Transradial approach for arteriovenous fistuloplasty is a safe and feasible option in patients requiring balloon-assisted maturation or with multi-focal juxta-anastomotic and venous stenosis.
Factors Associated with Binge Drinking during the Transition into Adulthood: Exploring Associations Within Two Distinct Young Adult Age Ranges
Authors: Leech Tamara GJ , Jacobs Sarah , Watson Dennis 
Published: August 2020

Background: Binge drinking among young adults aged 18-21 years has declined over the past decade, but binge drinking rates among people 22-25 years old have remained largely the same. This steady trend in later years represents a departure from the traditional course of maturing out of risky alcohol use, perhaps because young adults are delaying the transition into adulthood. Aims: This paper explores the relationship between binge drinking and aspects of the transition into adulthood that could inform interventions targeting these two distinct groups of young adults. Methods: We use survey data on 1,081 young adults aged 18-25 living in 10 Indiana counties. Our dataset is unique because it contains both college-attending and non-college attending young adults. We ran weighted logistic regressions to determine the association between college enrollment, living situation, roles common in adulthood, and stressors common during the transition to adulthood (e.g., relationships, economic conditions, job stability) and binge drinking. Results: Our data indicate that different factors are associated with binge drinking based on whether subjects who are in the earlier (18-21 years old) or later (22-25 years old) years of young adulthood. For example, within the 18-21 years old group, college enrollment is associated with higher rates of binge drinking, but it is not associated with increased binge drinking in the older age group. The type of stress related to binge drinking also varies by age group. Conclusion: Our results emphasize the need to disaggregate “young adulthood” into two separate periods when defining target populations and settings for binge drinking interventions.
CoBuilt 4.0: Investigating the potential of collaborative robotics for subject matter experts
Authors: Reinhardt Dagmar , Haeusler Matthias Hank , London Kerry , Loke Lian , Feng Yingbin , De Oliveira Barata Eduardo , Firth Charlotte , Dunn Kate , Khean Nariddh , Fabbri Alessandra , Wozniak-O’Connor Dylan , Masuda Rin 
Published: August 2020

Human-robot interactions can offer alternatives and new pathways for construction industries, industrial growth and skilled labour, particularly in a context of industry 4.0. This research investigates the potential of collaborative robots (CoBots) for the construction industry and subject matter experts; by surveying industry requirements and assessments of CoBot acceptance; by investing processes and sequences of work protocols for standard architecture robots; and by exploring motion capture and tracking systems for a collaborative framework between human and robot co-workers. The research investigates CoBots as a labour and collaborative resource for construction processes that require precision, adaptability and variability. Thus, this paper reports on a joint industry, government and academic research investigation in an Australian construction context. In section 1, we introduce background data to architecture robotics in the context of construction industries and reports on three sections. Section 2 reports on current industry applications and survey results from industry and trade feedback for the adoption of robots specifically to task complexity, perceived safety, and risk awareness. Section 3, as a result of research conducted in Section 2, introduces a pilot study for carpentry task sequences with capture of computable actions. Section 4 provides a discussion of results and preliminary findings. Section 5 concludes with an outlook on how the capture of computable actions provide the foundation to future research for capturing motion and machine learning.
Early experience utilizing artificial intelligence shows significant reduction in transfer times and length of stay in a hub and spoke model
Authors: Hassan Ameer E , Ringheanu Victor M , Rabah Rani R , Preston Laurie , Tekle Wondwossen G , Qureshi Adnan I 
Published: August 2020

Background Recently approved artificial intelligence (AI) software utilizes AI powered large vessel occlusion (LVO) detection technology which automatically identifies suspected LVO through CT angiogram (CTA) imaging and alerts on-call stroke teams. We performed this analysis to determine if utilization of AI software and workflow platform can reduce the transfer time (time interval between CTA at a primary stroke center (PSC) to door-in at a comprehensive stroke center (CSC)). Methods We compared the transfer time for all LVO transfer patients from a single spoke PSC to our CSC prior to and after incorporating AI Software (Viz.ai LVO). Using a prospectively collected stroke database at a CSC, demographics, mRS at discharge, mortality rate at discharge, length of stay (LOS) in hospital and neurological-ICU were examined. Results There were a total of 43 patients during the study period (median age 72.0 ± 12.54 yrs., 51.16% women). Analysis of 28 patients from the pre-AI software (median age 73.5 ± 12.28 yrs., 46.4% women), and 15 patients from the post-AI software (median age 70.0 ± 13.29 yrs., 60.00% women). Following implementation of AI software, median CTA time at PSC to door-in at CSC was significantly reduced by an average of 22.5 min. (132.5 min versus 110 min; p = 0.0470). Conclusions The incorporation of AI software was associated with an improvement in transfer times for LVO patients as well as a reduction in the overall hospital LOS and LOS in the neurological-ICU. More extensive studies are warranted to expand on the ability of AI technology to improve transfer times and outcomes for LVO patients.