bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of The Role, Audience, Format and Topic (RAFT) Technique on Students’ Skill in Writing Expository Text
Authors: Suciati Suciati 
Published: August 2020

This research examines the effectiveness of RAFT and conventional technique in improving high and low motivated students’ skill in writing expository text and explained the motivation interaction to their skill. RAFT is a system to help students understand their role as a writer, audience, varied formats for writing, and expected content. This research uses factorial design with 36 students of experimental group and 34 in control group. They are eleventh graders of <em>MA Tarbiyatul Banin</em>, Winong-Pati. The result shows that RAFT is effective in improving the high and low motivated students’ skill in writing expository text on the level of significance 0.05, the conventional technique is effective in improving the high and low motivated students’ skill in writing expository text on the level of significance 0.05. There is interaction of the students’ motivation to students’ skill in writing expository text using RAFT and conventional technique. By using RAFT, the high motivated students’ skill get more improvement and by using conventional technique, the low motivated students’ skill get more improvement. Further, the use of RAFT in improving the students’ skill in writing expository text is more effective than the use of conventional technique.
Revealing Student’s Reading Interest through creative WhatsApp Status
Authors: Budiastuti Riana Eka , Mulyadi Dodi 
Published: August 2020

Along with the rapid development of technology and digital era, this research investigated and reveal millennial students about their reading habit and interest. Specifically, this paper investigates about students’ reading interest through creative WhatsApp<em> </em>status. This study was carried out by 18 students taking “Basic Reading” class and “Cultural Based Reading” class. It was conducted with descriptive qualitative method by using interview and observation of the students’ WhatsApp <em>status</em> screenshot. It is found that 89% students of English Department Universitas Muhammadiyah Semarang are more interested in reading fiction than the factual text. Besides, students also find that learning using experiment with social media is fun and challenging.
ЭПИДЕМИЧЕСКИЙ ПРОЦЕСС COVID-19 В РОССИЙСКОЙ ФЕДЕРАЦИИ: ПРОМЕЖУТОЧНЫЕ ИТОГИ. СООБЩЕНИЕ 2.
Authors: Пшеничная Наталья , Лизинфельд Ирина , Журавлев Григорий 
Published: August 2020

Цель исследования. Промежуточный анализ компонентов эпидемического процесса COVID-19 в Российской Федерации, связанных с контактными лицами и вторичными случаями инфекции.
Материалы и методы. Выполнен анализ 190 856 первичных случаев COVID-19 и 146 996 контактных с ними лиц на основании отдельных данных мониторинга, проводимого Роспотребнадзором за январь–июнь 2020 г. Дана характеристика эпидемических очагов, контактных лиц с первичными случаями COVID-19 и вторичных случаев инфицирования.
Результаты.
Наибольший удельный вес контактных лиц выявлен у первичных больных с легкой формой COVID-19 - 50,02%. На пациентов со среднетяжелой формой пришлось 45,40% контактов, тяжелой - 4,58%. Пациенты с более легким течением COVID-19, имели большее число контактов, что, соответственно, приводило большему вторичных случаев инфекции.
В возрастной группе 41-64 лет наблюдался как наибольший процент первичных пациентов с COVID-19 - 44,42%, так и соответственно контактных с ними лиц - 44,51%. На возраст 18-40 лет приходилось 30,20% заболевших и 34,21% контактных лиц. Удельный вес несовершеннолетних пациентов в возрасте от 0-6 лет составил 2,70%, 7-17 лет - 4,02% заболевших и, соответственно этим возрастным группам, 1,94% и 3,13% контактных лиц.
Контакты в бытовых очагах, занимали ведущее значение в трансмиссии вируса во всех возрастных группах. Основную роль в передаче инфекции в эпидемических очагах различной локализации играли больные в возрасте от 40 до 64 лет. Удельный вес пациентов этой возрастной группы составил 42,02% в социальных учреждениях, 43,40% в быту и 47,70% в очагах по месту работы.
Заключение.
Наибольшее число контактов и соответственно вторичных случаев инфекции приходится на больных в возрасте от 18 до 64 лет с легкими и средне-тяжелыми формами заболевания. Контакты в бытовых очагах играют основную роль в передаче COVID-19 во всех возрастных группах. В возрасте от 18 до 64 лет важное значение имеет также трансмиссия инфекции по месту работы. Среди больных преобладают во всех очагах инфекции лица в возрасте 40-64 года. Полученные данные помогут оптимизировать меры по противодействию COVID-19.
CHARACTERISTICS OF COVID-19’S EPIDEMIC PROCESS IN RUSSIA, MARCH-JUNE 2020
Authors: Pshenichnaya Natalia , Lizinfeld Irina , Zhuravlev Grigory 
Published: August 2020

The epidemic process with local transmission began in Russia in March 2020.
Aim of study: to estimate the dynamics of epidemic process in Russia.
Data analysis of report form #970 of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing about COVID-19 cases during the first half of 2020.
Russia has specific characteristics of the epidemic process with significal differences of epidemic curves in the MaMR and other regions due to less strong restrictive measures outside of MaMR.
High frequency of Taenia solium antigen positivity in patients admitted for neurological disorders in the Rural Hospital of Mosango, Democratic Republic of Congo.
Authors: MUKENDI Deby , Kalo Jean-Roger Lilo , Lutumba Pascal , Barbé Barbara , Jacobs Jan , Yansouni Cedric P , Gabriël Sarah , Dorny Pierre , Chappuis François , Boelaert Marleen , Winkler Andrea S , Verdonck Kristiern , Bottieau Emmanuel 
Published: August 2020

Abstract
Background

The epidemiology of human cysticercosis and neurocysticercosis, caused by the larval stage of the pork tapeworm Taenia solium , is not well known in the Democratic Republic of Congo (DRC). As part of an etiological study, we consecutively evaluated from 2012 to 2016 all patients older than 5 years admitted for neurological disorders (neurology cohort) at the rural hospital of Mosango, province of Kwilu, DRC. No neuroimaging was available. A similar study was conducted among patients presenting with persistent fever (> 7 days) during the same period in the same hospital. In both studies, etiological diagnosis relied on a systematic set of reference laboratory assays and on pre-established clinical case definitions. The aim of this post-hoc analysis was to determine the frequency of T. solium infection in these neurology and persistent fever cohorts and to explore its association with specific neurological presentations and final etiological diagnoses.

Methods

We conducted a descriptive and analytic study between the group of neurological syndrome patients and persistent fever based on the presence or not the cysticercosis IgG using the B158/B60 enzyme-linked immunosorbent assay and of the LDBIO Cysticercosis Western Blot IgG assay, respectively..

Results

For the neurology cohort, 340 samples (of 351 enrolled patients) were available for analysis (males: 46.8%; mean age: 38.9 years). T. solium antigen positivity was found in 43 participants (12.6%; 95% confidence interval [CI] 9.3-16.7%), including 9 of 60 (15%) patients with epilepsy. Of the 148 evaluated samples from the persistent fever cohort (males: 39.9%; mean age: 19.9 years), 7 had positive T. solium antigen (4.7%; 95% CI 1.9-9.5%; P=0.009 when compared to the neurology cohort). No significant association was found within the neurology cohort between positivity and clinical presentation or final diagnoses. Of note, the antibody-based assay was found positive in only four (1.3%) of the participants of the neurology cohort and in none of the persistent fever cohort.

Conclusions

T. solium antigen positivity was frequent in patients admitted with neurological disorders in the Kwilu province, DRC. Further neuroimaging studies should explore whether neurocysticercosis is prevalent in this region.
Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell based in vitro disease-modeling: Convergence of schizophrenia and autism-related cellular phenotypes
Authors: Hathy Edit , Szabó Eszter , Varga Nóra , Erdei Zsuzsa , Tordai Csongor , Czehlár Boróka , Baradits Máté , Jezsó Bálint , Koller Júlia , Nagy László , Molnár Mária Judit , Nemoda Zsófia , Homolya László , Apáti Ágota , Réthelyi János M 
Published: August 2020

Abstract
Background: De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction and decreased community functioning. Several DNMs have been identified by examining SZ cases and their unaffected parents, however in most cases the biological significance of these mutations remains elusive. To overcome this limitation, we have developed an approach of using induced pluripotent stem cell (iPSC) lines from each member of a SZ case-parent trio, in order to investigate the effects of DNMs in cellular progenies of interest, particularly in dentate gyrus neuronal progenitors. Methods: We identified a male SZ patient characterized by early disease onset and negative symptoms, who is a carrier of 3 non-synonymous DNMs in genes LRRC7, KHSRP, and KIR2DL1. iPSC lines were generated from his and his parents’ peripheral blood mononuclear cells using Sendai virus-based reprogramming and differentiated into neuronal progenitor cells (NPCs) and hippocampal dentate gyrus granule cells. We used RNASeq to explore transcriptomic differences, and calcium (Ca 2+ ) imaging, cell proliferation, migration, oxidative stress, and mitochondrial assays to characterize the investigated NPC lines. Results: NPCs derived from the SZ patient exhibited transcriptomic differences related to Wnt-signaling, neuronal differentiation, axonal guidance and synaptic function, and decreased Ca 2+ reactivity to glutamate. Moreover, we could observe increased cellular proliferation, and alterations in mitochondrial quantity and morphology. Conclusions: The approach of reprograming case-parent trios represents an opportunity for investigating the molecular effects of disease-causing mutations, and comparing these in cell lines with reduced variation in genetic background. Our results are indicative of a partial overlap between schizophrenia and autism-related phenotypes in the investigated family. Limitations: Our study investigated only one family, therefore the generalizability of findings is limited. We could not derive iPSCs from two other siblings to test for possible genetic effects in the family that are not driven by DNMs. The transcriptomic and functional assays were limited to the NPC stage, although these variables should also be investigated at the mature neuronal stage.
Mean Platelet Volume (MPV): New diagnostic indices for co-morbidity of Tuberculosis and Diabetes Mellitus
Authors: xu feifan , qu shengyan , Wang lin , Qin Yongwei 
Published: August 2020

Abstract
Background: Tuberculosis (TB) and type 2 diabetes mellitus (DM) are global health diseases with high morbidity and mortality. Few studies have focused on platelet indices in TB-DM coinfection patients. The objective of this work was to analyze the platelet indices in TB, DM and TB-DM patients to assess the predictive value of the platelet index for the risk of these diseases.Methods: In total, 246 patients admitted to our hospital were distributed into three groups (113 TB, 59 DM and 74 TB+DM). A total of 133 individuals were also recruited as healthy controls (HC). Platelet indices, namely, platelet count (PC), mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW), were compared among the four groups, and the relationship with inflammatory markers was explored by using statistical software.Results: Our study discovered that MPV and PCT were significantly downregulated in TB+DM patients (9.95±1.25 fL, 0.20±0.05%, P<0.0001, P=0.0121, separately) compared with DM individuals (10.92±1.17 fL, 0.22±0.04%). Moreover, the changes in MPV were significantly higher in TB+DM patients (9.95±1.25 fL, P=0.0041) than in TB patients (9.42±1.01 fL). No differences were found in PLT and PDW among the four groups (P>0.05). The sensitivity and specificity of MPV in the differential diagnosis of DM patients vs TB+DM patients were 64.9% and 66.1% (P<0.0001), respectively, and the sensitivity and specificity of MPV between TB patients and TB+DM patients was 60.8% and 66.4%, respectively (P=0.003). MPV improved the diagnosis sensitivity when it was combined with clinical parameters, such as fasting blood glucose in DM and Mycobacterium tuberculosis culture result in TB (76.3% vs 64.9%, 72.6% vs 60.8%, P<0.0001, P=0.001, respectively). In addition, the sensitivity and specificity of PCT in the differential diagnosis of DM patients vs TB+DM patients were 69.5% and 59.4%, respectively (P=0.008). PCT improved the diagnosis sensitivity when combined with fasting blood glucose in DM (72.9% vs 64.9%, P=0.004). In addition, MPV was linked to CRP (C-reactive protein) [Ed1] and ESR (erythrocyte sedimentation rate) in the TB+DM patients (r = 0.3203, P =0.0054, r = 0.2504, P=0.0307) but PCT was not (r = 0.1905, r = 0.008675, P>0.05, respectively).Conclusions: Our research shows that MPV and PCT might be good clinical laboratory markers to distinguish TB+DM patients from TB or DM individuals, thus providing support for earlier clinical diagnosis, prevention, and therapy.When defining abbreviations and acronyms, please be consistent in whether it is the abbreviated or spelled-out form that appears in parentheses. Some journals request a specific style, so please review the journal's guidelines.
A practical nomogram for predicting cancer-specific survival in patients with clear-cell renal cell carcinoma
Authors: Wen Qian , Wang Xinwen , Wang Xiaoye , Bai Tiao , Tao Mei 
Published: August 2020

Abstract
Background: It has limitations in predicting patient cancer-specific survival to use of the traditional American Joint Committee on Cancer (AJCC) staging system alone. Objectives: We aimed to establish and evaluate a comprehensive prognostic nomogram and compare its prognostic value with the AJCC-7th staging system in adults diagnosed with ccRCC.Methods: We used the SEER database to identify 24477 cases of ccRCC between 2010 and 2015. In the development cohort, we used multivariate Cox proportional-hazards analyses to select significant variables, and used R software to establish a nomogram for predicting the 3-year and 5-year cancer-specific survival rates of ccRCC patients. In the development and validation cohorts, we compared our cancer-specific survival model with the AJCC-7th prognosis model to evaluate the performance of the nomogram by calculating the concordance index (C-index), Youden Index, area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI), and performing calibration plotting and decision curve analyses (DCAs). Results: Eleven identified independent prognostic factors were used to establish the nomogram. Age at diagnosis, being unmarried, higher grades, larger tumor size, higher AJCC-7th stage, lymph node metastases, bone metastases, liver metastases, lung metastases, radiotherapy, and no surgery were risk factors for the cancer-specific survival of ccRCC. The C-index, Youden Index, AUC, NRI, IDI, and calibration plots demonstrated the good performance of the nomogram compared to the AJCC-7th staging system. Moreover, the 3-year and 5-year DCA curves showed that the nomogram yielded net benefits that were greater than the traditional AJCC-7th staging system. Conclusion: This study is the first to indicate that married status is an important prognostic parameter in ccRCC. Our results also demonstrate that the developed nomogram can predict cancer-specific survival more accurately than the AJCC-7th staging system alone. The prognostic factors were easily obtained.
IMP-2005: an injury mortality prediction according to the Abbreviated Injury Scale 2005
Authors: Wang Muding , Qiu Wusi , Zhang Guohu , Zeng Yunji , Fan Wenhui , Wang Xueming , Shen Yi 
Published: August 2020

Abstract
Background: It has been 45 years since the injury severity score (ISS) was first introduced. The method is flawed in traumatic death prediction but still widely used. Based on the abbreviated injury scale 1998 (AIS_98), there is a relatively more accurate trauma scoring method that assesses the injury mortality prediction (IMP) and trauma mortality prediction model (TMPM) with the regression model. Currently, AIS 2005 (AIS_05) is widely used around the world for trauma scores. This article assesses whether the IMP-2005, an AIS_05 based model, is better than the ISS in predicting trauma results. Methods: Retrospective cohort study is based on the data of 1,198,885 injured patients in the National Trauma Data Bank hospitalized from 2012 to 2014. We established an injury mortality prediction (IMP-2005) model using AIS trauma codes (version 2005) and compared its performance with that of ISS by examining area under the receiver operating characteristic (ROC) curve, the Hosmer-Lemeshow (HL) statistic, and the Akaike information criterion.Results: IMP-2005 behaves significantly both better discrimination (ROCIMP-2005, 0.904; 95% confidence interval (CI), 0.900 to 0.908 and ROCISS, 0.844; 95% CI, 0.839 to 0.850) and calibration (HLIMP-2005, 37.7; 95% CI, 19.8 to 53 and HLISS, 221; 95% CI, 167 to 268) compared with ISS. Both models showed changes after the inclusion of gender, age, GCS, mechanism of injury, and mechanical ventilator, but the expansion of IMP-2005 still dominated ISS in every performance.Conclusions: The IMP-2005 provides far more improvement in discrimination and calibration compared with the ISS and accurate predictions of mortality. Therefore, we believe that this is a new and feasible scoring method of trauma research and should replace the ISS.
The Binding Behaviors between Cyclopentanocucurbit[6]uril and Three Amino Acids in the Solid and the Solution Phases
Authors: Cheng Si Yuan , Zhao Wei Wei , Yang Xi Nan , Wei Lian Tong , Tao Zhu , Ma Peihua 
Published: August 2020

Abstract
Binding behaviors between CyP6Q[6] and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance (1H NMR) spectroscopy, amino acids and isothermal titration calorimetry (ITC). The results showed that CyP6Q[6] forms a 1:2 inclusion complex with glycine, but 1:1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP6Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behavior.
Knowledge, Attitudes, and Practice among Malaysian in facing COVID-19 During the Implementation of Movement Control Order
Authors: Samah Asnarulkhadi Abu , muhammad mahazan , Sulaiman Abdul Hadi , Harun Siti Rahah 
Published: August 2020

Abstract
Background: The rapid acceleration in the number of hospitalizations and deaths of COVID-19 has attracted global attention and caused worldwide fear. In mid-March 2020, Malaysia has recorded the highest COVID-19 cases in Southeast Asia. As an immediate response, the Malaysian government has imposed Movement Control Order (MCO) to break the chain of infection and slow down the pandemic widespread. By mid-May 2020, R naught in Malaysia is at 0.3 as compared to 3.55 in mid-March 2020. Understanding the public’s knowledge, awareness, and reaction toward COVID-19 during the outbreak in the general population is paramount to give a real picture of the public’s responses in curbing the COVID-19 widespread. This study aims to determine the knowledge, attitude, and practice of social distancing among Malaysians during the COVID-19 outbreak. Methods: This cross-sectional study presents results from 3211 respondents by answering questionnaires through an online survey from 24 - 26 March 2020, one week after MCO was imposed. Responses were summarized using descriptive statistics and Chi-square test (χ²) statistic ware used to test whether the data from two or more groups of categories are associated with social distance practice.Results: Almost half of the respondents have an excellent level of knowledge (47.6%) and a positive attitude (47.4%) towards the COVID-19. Interestingly, more than half of the respondents (67.5%) performed good social distancing practice, while 30% exercised strict social distancing practice. A chi-square test shows that there is a significant association between knowledge and social distancing practice and no significant association between attitudes and social distancing practice. Conclusions: There is no COVID-19 vaccine nor herd immunity obtained yet, therefore the social distancing practice is the effective mechanism adopted to reduce the COVID-19 widespread, and Malaysia has proven it.
Identifying Public Stakeholders Effective on Mental Health Promotion in Iran
Authors: Damari Behzad , Esmaili Mohammad Reza Amir , rafiee noora , Hajebi Ahmad 
Published: August 2020

Abstract
Background: It is not always easy to put mental health on the agenda of sectors other than the health sector. However, it is now confirmed that mental health promotion policies need innovations beyond the scope of the health sector to be efficient. Thus, in this study, an attempt was made to identify the most effective stakeholders of the public sector in the field of mental health promotion in Iran to help the policy-makers of said sector and to encourage the inter-sectoral cooperation and further involvement of these effective sectors in mental health promotion plans.Methods: This was a mixed-methods study. From the data of the first step (literature review and a survey involving professors of relevant disciplines), the names of government agencies related to the domain of mental health were extracted. In the second step, a checklist was developed, the horizontal axis of which was the relevant organizations and the vertical axis was the social risk factors effective on mental health promotion. The data of this step were analyzed by the simple additive weighting method. In the final step, a table was plotted in the form of institutional mapping in order to summarize the organizations affecting each risk factor.Results: The Islamic Consultative Assembly, the Ministry of Interior, the Islamic Republic of Iran Broadcasting, the Ministry of Cooperatives, Labor, and Social Welfare, and the Ministry of Education were identified as five organizations with the greatest impacts on the social determinants of mental health promotion in Iran. Conclusions: Significant impacts can be exerted by institutions such as the Islamic Consultative Assembly (as the legislator), the Ministry of Interior and its subsidiary entities such as municipalities and governors (as the administrators of homeland security and support for safe and appropriate urban and local facilities), the Islamic Republic of Iran Broadcasting (as the national media), the Ministry of Cooperatives, Labor, and Social Welfare (as the institution in charge of employment, job security, and social welfare), and the Ministry of Education (as the educational institution of the country).