bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Prevalence of Headaches During Covid‐19 Infection: A Retrospective Cohort Study
Authors: Poncet‐Megemont Louis , Paris Pauline , Tronchere Amélie , Salazard Jean‐Pascal , Pereira Bruno , Dallel Radhouane , Aumeran Claire , Beytout Jean , Jacomet Christine , Laurichesse Henri , Lesens Olivier , Mrozek Natacha , Vidal Magali , Moisset Xavier 
Published: August 2020

ObjectivesTo document the prevalence of new headaches in patients with Covid‐19 infection and the potential association with other neuro‐sensorial symptoms (anosmia and ageusia). The persistence of these symptoms 1 month after recovery was also documented.BackgroundHeadaches are a very common symptom of viral infections. Surprisingly, early Chinese studies reported a relatively low prevalence (12‐15%) of headaches associated with Covid‐19.MethodsAll the patients with laboratory‐confirmed or chest‐CT‐confirmed Covid‐19 infection, diagnosed between February 27th and April 15th, 2020 in the dedicated laboratory of Clermont‐Ferrand University Hospital were followed for 1 month after recovery.ResultsA total of 139 consecutive patients (mean [SD] age, 48.5 [15.3] years; 87 women [62.6%]) were interviewed 1 month after disappearance of fever and dyspnea (semi‐structured phone interview). Overall, 59.0% (82/139) of people with Covid‐19 had mild disease, 36.7% (51/139) had severe disease, and 4.3% (6/139) had critical illness. Eighty‐two (59.0%; 95% CI: 50.3 to 67.3) reported new headaches during the acute phase and 3.6% (5/139) had persistent headaches 1 month after fever and dyspnea remission. Anosmia and ageusia were also very common, occurring in 60.4% (84/139) and 58.3% (81/139) of the patients, respectively. These 2 symptoms persisted in 14.4% (20/139) and 11.5% (16/139) of Covid‐19 patients 1 month after recovery. Headaches were neither clearly associated with anosmia, nor with ageusia, and were not associated with disease severity (ie, requiring hospitalization or intensive care unit).ConclusionThis specific study highlights the high prevalence of new headaches during Covid‐19 infection in French patients. Further studies are needed to refine the characterization of patients with Covid‐19‐associated headaches.
Scoping review of patients’ attitudes about their role and behaviours to ensure safe care at the direct care level
Authors: Duhn Lenora , Godfrey Christina , Medves Jennifer 
Published: August 2020

AbstractBackgroundTo improve harm prevention, patient engagement in safety at the direct care level is advocated. For patient safety to most effectively include patients, it is critical to reflect on existing evidence, to better position future research with implications for education and practice.MethodsAs part of a multi‐phase study, which included a qualitative descriptive study (Duhn & Medves, 2018), a scoping review about patient engagement in safety was conducted. The objective was to review papers about patients’ attitudes and behaviours concerning their involvement in ensuring their safe care. The databases searched included MEDLINE, CINAHL and EMBASE (year ending 2019).ResultsThis review included 35 papers about “Patient Attitudes” and 125 papers about “Patient Behaviours”—indicative of growing global interest in this field. Several patterns emerged from the review, including that most investigators have focused on a particular dimension of harm prevention, such as asking about provider handwashing, and there is less known about patients’ opinions about their role in safety generally and how to actualize it in a way that is right for them. While patients may indicate favourable attitudes toward safety involvement generally, intention to act or actual behaviours may be quite different.ConclusionThis review, given its multi‐focus across the continuum of care, is the first of its kind based on existing literature. It provides an important international “mapping” of the initiatives that are underway to engage patients in different elements of safety and their viewpoints, and identifies the gaps that remain.
Clinicopathological and molecular analyses of linearly expanded epithelial cells with β‐catenin alterations, “β‐catenin signature”, in the normal fallopian tube
Authors: Koyama Kei , Maeda Daichi , Kito Masahiko , Tamura Daisuke , Kudo‐Asabe Yukitsugu , Katoh Hiroto , Ishikawa Shumpei , Nanjo Hiroshi , Terada Yukihiro , Goto Akiteru 
Published: August 2020

AimsRecent advances in next‐generation sequencing have made it clear that clonal expansion of cells harbouring driver gene mutations occurs in physiologically normal epithelium. Molecular analysis of tubal epithelium has been almost exclusively confined to the TP53 pathway, which is involved in serous carcinogenesis. Other oncogenic events have not been explored in detail. Here, we report the linear expansion of fallopian tubal epithelial cells exhibiting an altered β‐catenin profile (β‐catenin signature). Through molecular analyses, we determined the incidence and clinicopathological significance of β‐catenin signatures.Methods and resultsWe evaluated 64 specimens of surgically removed bilateral fallopian tubes. Thirty‐three β‐catenin signatures were identified in 13 cases (20.3%); these patients were significantly younger than those without β‐catenin signatures (median ages of 44 and 57 years, respectively, P = 0.0317). No correlation between β‐catenin signature and any clinical factor was observed. CTNNB1 mutations were detected in three of eight β‐catenin signatures when tissues were microdissected and subjected to Sanger sequencing in two representative cases.ConclusionsThis is the first report of the CTNNB1 mutation in clusters of morphologically bland tubal epithelial cells. The results of this study indicate that β‐catenin signatures are common, and they may be a part of diverse molecular alterations occurring in normal tubal epithelium.
Influence of minimally invasive endodontic access cavities on root canal shaping and filling ability, pulp chamber cleaning and fracture resistance of extracted human mandibular incisors
Authors: Rover G. , de Lima C. O. , Belladonna F. G. , Garcia L. F. R. , Bortoluzzi E. A. , Silva E. J. N. L. , Teixeira C. S. 
Published: August 2020

AbstractAimTo evaluate the influence of the location and design of endodontic access cavities on root canal shaping and filling ability, pulp chamber cleaning and fracture resistance of extracted human mandibular incisors.MethodologyAfter pre‐selection using periapical radiographs, forty extracted intact human mandibular incisors were scanned in a micro‐computed tomographic device. The teeth were matched based on similar anatomical features of the canals and assigned to four experimental groups (n = 10) according to the endodontic access cavity and root canal preparation protocol: traditional/TRUShape (T/TRU); traditional/MTwo (T/MT); minimally invasive/TRUShape (MI/TRU); and minimally invasive/MTwo (MI/MT). The samples were scanned after root canal instrumentation and filling procedures. The parameters evaluated were as follows: volume and area of the root canal, noninstrumented canal areas, canal transportation and centring ratio, accumulated hard tissue debris, voids in root canal fillings and remnants of root canal filling materials in the pulp chamber. After root canal filling and cavity restoration procedures, the samples were submitted to a fracture resistance test. Data were statistically analysed using Shapiro–Wilk, one‐way anova and Bonferroni tests with a significance level of 5% (α = 0.05).ResultsThere was no difference regarding all parameters evaluated before and after root canal preparation (volume and area of the root canal, noninstrumented canal areas, canal transportation and centring ratio, and accumulated hard tissue debris) amongst the groups (P > 0.05). MI/TRU and MI/MT groups were associated with significantly more voids in root canal fillings when compared to the T/TRU and T/MT groups (P < 0.05). Percentage of root canal filling material remnants in the pulp chamber after cleaning procedures and mean fracture resistance values were not significantly different amongst the four experimental groups (P > 0.05).ConclusionsThe location and design of the endodontic access cavity did not impact on root canal preparation nor resistance to fracture of extracted mandibular incisors, regardless of the instrument used. Minimally invasive access cavities were associated with significantly more voids in root canal fillings.
Development of antimicrobial whey protein‐based film containing silver nanoparticles biosynthesised by Aspergillus Niger
Authors: Çağrı Mehmetoğlu Arzu , Sezer Elif , Erol Sümeyye 
Published: August 2020

SummaryApplications of whey protein concentrate (WPC)‐based films have been limited in the food industry due to their poor mechanical properties. This research aims to evaluate the effect of silver nanoparticles (AgNPs) synthesised by Aspergillus niger on the mechanical and antimicrobial properties of WPC‐based films. The biosynthesised AgNPs solution was added into the WPC film formula at the concentration of 0, 0.25 and 1.25 mm. The film samples containing AgNPs inhibited the growth of Staphylococcus aureus, Escherichia coli O157:H7, Salmonella Enteritidis, Listeria monocytogenes, Williopsis saturnus or Aspergillus sydowii with zones of inhibition ranging from 13 to 19.7 mm. Incorporation of AgNPs improved tensile strength and water barrier properties of the films by 84% and 67%, respectively. However, per cent elongation at the break of the film decreased from 37% to 11% by the addition of 1.25 mm AgNPs. This work provides a protocol for preparing improved antimicrobial WPC films with AgNPs.
Liquidity risk and corporate bond yield spread: Evidence from China
Authors: Chen Yinghui , Jiang Lunan 
Published: August 2020

AbstractThis paper investigates the contribution of liquidity risk to Chinese corporate bond spreads. We calculate corporate bond spreads based on the full treasury yield curve and establish a set of liquidity measures of the Chinese corporate bonds. Our empirical study shows that liquidity premium accounts for a relatively smaller portion of corporate bond spread in China, although the market liquidity is low and corporate bond issuers are strictly pre‐screened. These findings are interesting, as the developed markets have better liquidity and less pre‐issuance restriction, and liquidity premium still explains a relatively larger portion of corporate bond spread. Besides, we also explore the determinants of Chinese corporate bond liquidity and default premiums.
Use of a novel silicone‐acrylic drape with negative pressure wound therapy in anatomically challenging wounds
Authors: Fernández Luis G. , Matthews Marc R. , Benton Carol , Buresch Rebecca , Sutherland Angela , Tillison Natalie , Brooks Jenny 
Published: August 2020

AbstractNegative pressure wound therapy (NPWT) utilises a polyurethane drape with acrylic adhesive over foam dressings to create a seal. In anatomically challenging areas, ancillary products are frequently used. Additionally, health care providers are unable to reposition the drape once placed. A novel hybrid drape consisting of polyurethane film with acrylic adhesive and silicone perforated layer has been developed to allow for repositioning after initial placement and easy removal. This six‐patient case series evaluates the use of NPWT with hybrid drape over anatomically challenging wounds. Three males and three females were treated. Dressing changes occurred every 2 to 3 days. Drape application, repositioning, and ability to maintain a seal were evaluated. During application, the drape was repositioned 1 to 2 times without periwound skin irritation in 4/6 wounds. Prior to initial application, ancillary products were applied to help create a seal. However, by the second or third application, ancillary products were no longer used in 4/6 wounds. None of the dressing applications resulted in negative pressure seal leaks. In these patients, health care providers could reposition the hybrid drape after initial placement without periwound skin irritation and successfully create a negative pressure seal without ancillary products in anatomically challenging wound locations.
Collaborative care for the wearable cardioverter defibrillator patient: Getting the patient and medical team “vested and active”
Authors: Sears Samuel F. , Tripp Connor , Huber Nichelle L. , Khan Saleen , Nekkanti Rajasekhar , Burch Ashley E. , Pokorney Sean D. 
Published: August 2020

AbstractPatients with a reduced ejection fraction of 35% or less and a history of myocardial infarction (MI) are at increased risk of sudden cardiac death (SCD). These patients have a class I indication for an implantable cardioverter‐defibrillator after allowing time for medical therapy optimization and potential cardiac recovery. The rates of SCD are highest in this “gap” period early after a cardiac event, and the wearable cardioverter‐defibrillator (WCD) is an intervention that can be used to protect against SCD during this time period. There has been a clinical trial that randomized patients with a reduced ejection fraction at the time of MI to a WCD versus control. Results of the trial showed no statistically significant difference in the primary endpoint of SCD. There are many intricacies to the interpretation of the trial, including the importance of patient adherence to WCD therapy, which is affected by the patient experience and psychological factors. Patients with a new cardiomyopathy are affected by a mix of psychological factors, including the feeling of safety and protection from a WCD contrasted by the WCD providing a reminder of awareness and fear of ventricular arrhythmias and SCD. Beyond the capabilities of a WCD to defibrillate a life‐threatening ventricular arrhythmia, the device can also provide activity and heart failure diagnostics monitoring. Patients need to be engaged in shared decision‐making conversations about a WCD, so that patients can make a decision based on their own values construct, ultimately increasing adherence among the patients that want a WCD.
Impedance, power, and current in radiofrequency ablation: Insights from technical, ex vivo, and clinical studies
Authors: Bourier Felix , Ramirez F. Daniel , Martin Claire A. , Vlachos Konstantinos , Frontera Antonio , Takigawa Masateru , Kitamura Takeshi , Lam Anna , Duchateau Josselin , Pambrun Thomas , Cheniti Ghassen , Derval Nicolas , Denis Arnaud , Sacher Frédéric , Hocini Mélèze , Haissaguerre Michel , Jais Pierre 
Published: August 2020

AbstractBackgroundRadiofrequency (RF) power is routinely considered during RF application. In contrast, impedance has been relatively poorly studied, despite also influencing RF lesion creation. The aim of this study was to examine the influence of electric impedance on RF lesion characteristics and on clinical RF ablation parameters.Methods and ResultsIn the first part of the study, power and impedance were systematically varied and the resulting current was calculated using custom‐made software. In the second part of the study, ablation lesions (n = 40) were analyzed in a porcine ex vivo model. RF applications were delivered in cardiac muscle preparations with systematically varied values of electric impedance using a contact force ablation catheter. In the third part of the study, n = 3378 clinical RF applications were analyzed, power, impedance, and current data were exported and correlated with clinical patient data. 20 ± 3 W/80 Ω, 30 ± 3 W/120 Ω, 40 ± 3 W/160 Ω, and 50 ± 3 W/200 Ω RF applications resulted in 498 ± 40, 499 ± 26, 500 ± 20, and 500 ± 16 mA RF current, which were not significantly different (p = .32). Ablation lesions were significantly different in depth and diameter when applied with the same power but different impedances (p < .01); lesion sizes decreased when increasing impedance. In clinical data, a large range of delivered current (e.g., 39–40 W: 530–754 mA) was measured, due to variations in impedance.ConclusionsRF lesion creation is determined by current rather than by power. During clinical RF ablation procedures, impedance significantly influences current delivery and varies considerably between patients. Impedance and current are clinically relevant parameters that should be considered during RF ablation.
Collagen Type III Alpha 1 chain regulated by GATA‐Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma
Authors: Huang Runzhi , Li Zhenyu , Zhu Xiaolong , Yan Penghui , Song Dianwen , Yin Huabin , Hu Peng , Lin Ruoyi , Wu Shengyu , Meng Tong , Zhang Jie , Huang Zongqiang 
Published: August 2020

AbstractSome studies suggested the prognosis value of immune gene in lower grade glioma (LGG). Recurrence in LGG is a tough clinical problem for many LGG patients. Therefore, prognosis biomarker is required. Multivariate prognosis Cox model was constructed and then calculated the risk score. And differential expressed transcription factors (TFs) and differential expressed immune genes (DEIGs) were co‐analysed. Besides, significant immune cells/pathways were identified by single sample gene set enrichment analysis (ssGSEA). Moreover, gene set variation analysis (GSVA) and univariate Cox regression were applied to filter prognostic signalling pathways. Additionally, significant DEIG and immune cells/pathways, and significant DEIG and pathways were co‐analysed. Further, differential enriched pathways were identified by GSEA. In sum, a scientific hypothesis for recurrence LGG including TF, immune gene and immune cell/pathway was established. In our study, a total of 536 primary LGG samples, 2,498 immune genes and 318 TFs were acquired. Based on edgeR method, 2,164 DEGs, 2,498 DEIGs and 31 differentials expressed TFs were identified. A total of 106 DEIGs were integrated into multivariate prognostic model. Additionally, the AUC of the ROC curve was 0.860, and P value of Kaplan‐Meier curve < 0.001. GATA6 (TF) and COL3A1 (DEIG) were selected (R = 0.900, P < 0.001, positive) as significant TF‐immune gene links. Type II IFN response (P < 0.001) was the significant immune pathway. Propanoate metabolism (P < 0.001) was the significant KEGG pathway. We proposed that COL3A1 was positively regulated by GATA6, and by effecting type II IFN response and propanoate metabolism, COL3A1 involved in LGG recurrence.
Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway
Authors: Mei Ying , Liu Bo , Su Hao , Zhang Hao , Liu Fei , Ke Qingjin , Sun Xiaoou , Tan Wen 
Published: August 2020

AbstractCardiomyocyte dysfunction is attributed to excess oxidative damage, but the molecular pathways involved in this process have not been completely elucidated. Evidence indicates that isosteviol sodium (STVNa) has cardioprotective effects. We therefore aimed to identify the effect of STVNa on cardiomyocytes, as well as the potential mechanisms involved in this process. We established two myocardial hypertrophy models by treating H9c2 cells with high glucose (HG) and isoprenaline (ISO). Our results showed that STVNa reduced H9c2 mitochondrial damage by attenuating oxidative damage and altering the morphology of mitochondria. The results also indicated that STVNa had a positive effect on HG‐ and ISO‐induced damages via mitochondrial biogenesis. The protective effects of STVNa on cardiomyocytes were associated with the regulation of the SIRT1/PGC‐1α signalling pathway. Importantly, the effects of STVNa involved different methods of regulation in the two models, which was confirmed by experiments using an inhibitor and activator of SIRT1. Together, the results provide the basis for using STVNa as a therapy for the prevention of cardiomyocyte dysfunctions.
Primary care providers perform more neurologic visits than neurologists among Medicare beneficiaries
Authors: Lin Chun Chieh , Hill Chloe E. , Burke James F. , Kerber Kevin A. , Hartley Sarah E. , Callaghan Brian C. , Skolarus Lesli E. 
Published: August 2020

AbstractRationale, aims and objectivesLittle is known about which medical providers, other than neurologists, are involved in the care of neurologic conditions. We aimed to describe the current distribution of outpatient neurologic care by provider type.MethodsWe conducted a restrospective, cross‐sectional analysis using a 20% national sample claims database that contains information on medical care utilizations from adult Fee‐for‐Service Medicare beneficiaries in 2015. We identified patient visits for evaluation and management services for common neurologic conditions and by medical provider type. The main outcome was the proportion of visits for neurologic conditions by medical provider type, both in aggregate and across neurologic conditions.Results40% of neurologic visits were performed by primary care providers (PCPs) and 17.5% by neurologists. The most common neurologic conditions were back pain (49.3%), sleep disorders (8.0%), chronic pain/abnormality of gait (6.4%), peripheral neuropathy (5.9%), and stroke (5.5%). Neurologists cared for a large proportion of visits for Parkinson's disease (75.6% vs 20.8%), epilepsy (70.9% vs 26.6%), multiple sclerosis (63.9% vs 26.2%), other central NS disorders (54.2% vs 24.9%), and tremor/RLS/ALS (54.0% vs 31.2%) compared to PCPs. PCPs provided a greater proportion of visits for dizziness/vertigo (57.8% vs 9.3%) and headache/migraine (50.4% vs 35.0%) compared to neurologists.ConclusionsPCPs perform more neurologic visits than neurologists. With the anticipated increased demand for neurologic care, strategies to optimize neurologic care delivery could consider expanding access to neurologists as well as supporting PCP care for neurologic conditions.
Effect of substrate and cement on the final color of zirconia‐based all‐ceramic crowns
Authors: Sonza Queli N. , Della Bona Alvaro , Pecho Oscar E. , Borba Marcia 
Published: August 2020

AbstractObjectiveTo evaluate the influence of the substrate and the cement on the final color of ceramic crowns.MethodsProsthetic crowns (framework + porcelain) were fabricated using two all‐ceramic systems (YZ, 3 mol% yttria‐stabilized tetragonal zirconia; IZ, alumina‐based zirconia‐reinforced glass‐infiltrated ceramic) and a metal‐ceramic system (MC; n = 8). Metal (M) and resin (R) were used as substrate abutments. For R substrate, crowns were evaluated as seated (R) and after cementation (R‐C). CIELAB color coordinates were obtained using a dental spectrophotometer with D65 light illumination. CIELAB, CIEDE2000 (1:1:1) and CIEDE2000 (2:1:1) color difference metrics were used. Data were analyzed using 95% confidence intervals and compared to perceptibility (PT) and acceptability (AT) thresholds.ResultsThe , ∆E00(1 : 1 : 1), and ∆E00(2 : 1 : 1) values of the restorative systems evaluated using different substrates (M.R) were similar to the AT values of each metric. When non‐cemented and cemented crowns were evaluated (R.R‐C), MC had color difference values at PT and below AT; while YZ and IZ showed similar values to AT, for and ∆E00(1 : 1 : 1) metrics.ConclusionThe substrate and cement affected the final color of zirconia‐based all‐ceramic crowns, but the color differences corresponded to an acceptable match.Clinical SignificanceAs both substrate and cement influence the final color of multi‐layered ceramic prosthesis, dentists and dental technicians should understand the optical properties of dental ceramics to reproduce the natural appearance of dental structures and maximize the chance for excellent color matches.