bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents
Authors: Póti Ádám , Gyergyák Hella , Németh Eszter , Rusz Orsolya , Tóth Szilárd , Kovácsházi Csenger , Chen Dan , Szikriszt Bernadett , Spisák Sándor , Takeda Shunichi , Szakács Gergely , Szallasi Zoltan , Richardson Andrea L. , Szüts Dávid 
Published: November 2019

Abstract
Background
Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint also give rise to somatic mutation patterns that can be used for treatment prediction.

Results
Using whole genome sequencing of an isogenic knockout cell line panel, we find a universal HR deficiency-specific base substitution signature that is similar to COSMIC signature 3. In contrast, we detect different deletion phenotypes corresponding to specific HR mutants. The inactivation of BRCA2 or PALB2 leads to larger deletions, typically with microhomology, when compared to the disruption of BRCA1, RAD51 paralogs, or RAD54. Comparison with the deletion spectrum of Cas9 cut sites suggests that most spontaneously arising genomic deletions are not the consequence of double-strand breaks. Surprisingly, the inactivation of checkpoint kinases ATM and CHK2 has no mutagenic consequences. Analysis of tumor exomes with biallelic inactivating mutations in the investigated genes confirms the validity of the cell line models. We present a comprehensive analysis of sensitivity of the investigated mutants to 13 therapeutic agents for the purpose of correlating genomic mutagenic phenotypes with drug sensitivity.

Conclusion
Our results suggest that no single genomic mutational class shows perfect correlation with sensitivity to common treatments, but the contribution of COSMIC signature 3 to base substitutions, or a combined measure of different features, may be reasonably good at predicting platinum and PARP inhibitor sensitivity.
Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation
Authors: Briand Joséphine , Nadaradjane Arulraj , Bougras-Cartron Gwenola , Olivier Christophe , Vallette François M. , Cartron Pierre-François 
Published: November 2019

AbstractBackgroundDiuron is an environmental component listed as a likely human carcinogen. Several other studies report that diuron can be oncogenic for bladder, urothelial, skin, and mammary cells. No study mentions the putative effect of diuron on the glioma occurrence.ObjectivesWe here wanted to investigate the effects of diuron exposure on the glioma occurrence while wishing to incriminate a putative implication of DNA methylation modulation in this process.MethodsIn in vivo model of glioma, diuron exposure was firstly compared or combined with oncogenic overexpressions already known to promote gliomagenesis. ELISA quantifying the 5-methylcytosine level on DNA was performed to examine the global DNA methylation level. Quantitative real-time polymerase chain reaction and proximity ligation in situ assay were performed to identify the molecular causes of the diuron-induced changes of DNA methylation. The signatures diuron-induced changes of DNA methylation were analyzed in a cohort of 23 GBM patients.ResultsDiuron exposure is not sufficient to promote glioma, such as the oncogenic overexpression of Akt or Ras. However, the combination of diuron exposure and Akt overexpression promotes glioma. We observed that the diuron/Akt-induced glioma is characterized by three phenotypic signatures characterizing cancer cells: a global DNA hypomethylation, a loss of sensitivity to cell death induction, and a gain of signals of immune escape. Our data associated these phenotypes with three aberrant DNA methylation signatures: theLLT1,PD-L1, andBcl-whypomethylations. Strikingly, we observed that these three concomitant hypomethylations were only observed in GBM patients having a potential exposure to diuron via their professional activity.ConclusionsAs single player, diuron is not an oncogenic of glioma, but it can participate to the glioma formation in association with other events (also devoid of oncogenic property as single player) such as Akt overexpression.
Existence and multiplicity of solutions for fractional Schödinger equation involving a critical nonlinearity
Authors: Yun Yongzhen , An Tianqing , Ye Guoju 
Published: November 2019

AbstractIn this paper, we investigate the fractional Schödinger equation involving a critical growth. By using the principle of concentration compactness and the variational method, we obtain some new existence results for the above equation, which improve the related results on this topic.
Hepatic sclerosing hemangioma mimics hepatic malignancies: a case report and multidisciplinary approach
Authors: Sweed Dina M. , Fayed Zeinab A. , Sweed Enas M. , El-Sherif Ahmed , Mohamady Mohamed 
Published: November 2019

Abstract
Background
Hepatic sclerosing hemangiomas (HSH) are rare benign vascular tumors that mimic radiologically hepatic malignancies. HSH is characterized by extensive fibrosis and hyalinosis as a result of degeneration and thrombosis. Pre-operative diagnosis is very difficult and most of the cases undergo surgical resections.

Case presentation
A 65 years old, hepatitis C virus-infected female presented by an accidentally discovered hepatic focal lesion. Magnetic resonance imaging (MRI) showed a T2 hyperintense mass displaying peripheral enhancement in porto-venous phase. The patient had a simultaneous typical hepatic hemangioma and multiple vertebral bodies’ hemangiomata. Tissue-guided biopsy revealed a densely sclerotic stroma containing vascular spaces with occasional obliteration of the lumen. Immunohistochemical staining was performed for Pan CK, CD34, SMA, VEGF, and c-Kit which confirmed the vascular nature of neoplasm and the involuting phase of hemangioma development. The patient was reassured and recommended for a regular radiological follow-up to reassess the lesion size.

Conclusion
The definitive preoperative diagnosis of HSH is still problematic. However, the awareness of surgeons by this entity, peripheral enhancement in porto-venous phase on dynamic MRI, the presence of simultaneous typical hepatic hemangioma in the absence of cancer history could raise suspicion for HSH. Liver biopsy is still the gold standard in approaching the accurate diagnosis.
Guidance on the use of MRI for treatment planning in radiotherapy clinical trials
Authors: Johnstone Robert I , Guerrero-Urbano Teresa , Michaelidou Andriana , Greener Tony , Miles Elizabeth , Eaton David , Thomas Christopher 
Published: November 2019

The aim of this article is to propose meaningful guidance covering the technical and safety issues involved when designing or conducting radiotherapy clinical trials that use MRI for treatment planning. The complexity of imaging requirements will depend on the trial aims, design and MRI methods used.
The use of MRI within the RT pathway is becoming more prevalent and clinically appropriate as access to MRI increases, treatment planning systems become more versatile and potential indications for MRI-planning in RT are documented. Novel MRI-planning opportunities are often initiated and validated within clinical trials.
The guidance in this document is intended to assist researchers designing RT clinical trials involving MRI, so that they may provide sufficient information about the appropriate methods to be used for image acquisition, post-processing and quality assurance such that participating sites complete MRI to consistent standards. It has been produced in collaboration with the National Radiotherapy Trials Quality Assurance Group (RTTQA).
As the use of MRI in RT is developed, it is highly recommended for researchers writing clinical trial protocols to include imaging guidance as part of their clinical trial documentation covering the trial-specific requirements for MRI procedures. Many of the considerations and recommendations in this guidance may well apply to MR-guided treatment machines, where clinical trials will be crucial. Similarly, many of these recommendations will apply to the general use of MRI in RT, outside of clinical trials.
This document contains a large number of recommendations, not all of which will be relevant to any particular trial. Designers of RT clinical trials must therefore take this into account. They must also use their own judgement as to the appropriate compromise between accessibility of the trial and its technical rigour.
Meaningful practices: The contemporary relevance of traditional making for sustainable material futures
Authors: Walker Stuart , Evans Martyn , Mullagh Louise 
Published: November 2019

Abstract
This article explores the relationship between design for sustainability and traditional making practices. It presents results from key informant interviews and observational research into traditional hand making of functional goods in Santa Fe in the United States, Jingdezhen, China, various locations in New South Wales, Australia and Cumbria, United Kingdom. We find that such goods fall into three main categories, primarily utilitarian, symbolic and aesthetic. These practices are discussed in terms of their contemporary relevance, potential futures and relationship to current understandings of sustainability. More specifically, they are considered against the four elements of the Quadruple Bottom Line of Design for Sustainability (), a rigorous interpretation extended from the philosophy of , which comprises: practical meaning including environmental impacts; social meaning; personal meaning; and economic means. The originality of this research lies in the development of new arguments and insights with regard to the complex issues of design for sustainability and traditional making practices. Significantly, we find that many of these practices are intellectually consistent with broad, contemporary understandings of design for sustainability. However, we also find that it is often not easy to reconcile these practices with modern consumer culture. Our research shows that pursuing these practices part-time for their own sake, rather than for primarily commercial reasons can often facilitate the pursuit of excellence and the continuation of cultural traditions.
The permanency of film festivals: Archiving the changing India
Authors: Acciari Monia 
Published: November 2019

Abstract
Time and space are two dimensions that define a film festival in relation to duration, cultural, social, urban and political relations to the event. While the notion of space is well documented by the literature on film festivals, the idea of time is merely connected to the length of the event, mostly defined as volatile in nature. The overall aim of this article is to present an understanding of film festivals as multifaceted sociocultural and historical events beyond the idea of volatility that is naturally conferred to them. The idea of diverse intersecting temporalities is explored in this article by observing curated units of a festival – commemorative events – as loci to uncover the distinctive connotations of a changing nation. Time in film festival is discussed here not only as a dimension defining the length of the event, but also as an active element able to present history, moments of remembrance and renegotiate and contextualize current political and social instances. Hence, it is argued that festivals can be considered within the broad debate of archive a counter-archive, in which history and documents (the films) become channels to reassess the everyday social life of India, and shape a renovated image of the nation.
Optimizing Suitable Conditions for the Removal of Ammonium Nitrogen by a Microbe Isolated from Chicken Manure
Authors: Zhang Yan , Fu Chun-Yan , Li Xin-Hua , Yan Pei-Pei , Shi Tian-Hong , Wu Jia-Qiang , Wei Xiang-Fa , Liu Xue-Lan 
Published: November 2019

AbstractStrain C was isolated from chicken manure, and its phenotypic characteristics were gram-stain negative, yellow-pigmented, aerobic bacterium, heterotrophic, non-motile, chemoorganotrophic, non-gliding as well as non-spore-forming. A 16S rRNA gene sequence analysis showed that strain C occupied a distinct lineage within the family of the genus Chryseobacterium, and it shared highest sequence similarity with Chryseobacterium solincola strain 1YB-R12 (80%). The new isolate has been studied for removing ammonium-nitrogen (NH4-N) and the optimization of suitable conditions. The strain C was able to degrade over 42.8% of NH4-N during its active growth cycle. Experimental study of the effect of temperature and pH on NH4-N removal showed that the temperature and pH optima for NH4-N removal were 30–35℃ and 4–8, respectively. The results indicated that strain C shows a potential application for wastewater treatment.
Effects of Fluoride and Sulphate Mineralizers on the Properties of Reconstructed Steel Slag
Authors: Xu Ying , Yang Shan-shan , Wang Qiao-ling , Hu Chen-guang 
Published: November 2019

Abstract
Improving the cementitious activity and volume stability of steel slag by thermal reconstruction is an innovative method for efficient utilization of steel slag. In this study, different amounts of CaF2 and CaSO4 were added to steel slag as a mineralizer based on the determining admixtures needed for the reconstruction reaction, and the effects of CaF2 and CaSO4 on the cementitious activity and volume stability of the reconstructed steel slag were investigated. The results show that when the CaF2 content is increased to 5 wt%, the cementitious activity index of the reconstructed steel slag gradually increases to 92%, which is 12% higher than the first level technical requirement specified by the national standards, and the free CaO (f - CaO) and MgO (f-MgO) contents gradually decrease to 0.35 and 0.13 wt%, respectively. With increasing CaSO4 content, the cementitious activity index first increases and then decreases, while the contents of f -CaO and f-MgO show the opposite trend. When the CaSO4 content is 2 wt%, the activity index is 105%,which is 25%higher than the first level technical requirement specified by the national standards, and the f -CaO and f-MgO contents reach minima of 0.44 and 0.35 wt%, respectively.
Vom Spitzen- zum Spezialbedarf
Authors: Kreusch Julia , Röschlein Jens 
Published: November 2019

Zusammenfassung
Der Beitrag problematisiert eingangs den in den Richtlinien für die Fachinformationsdienste (FID) eingeführten Leitbegriff „Spitzenbedarf“ und dessen Ablösung durch „Spezialbedarf“. In der Zusammenfassung der Evaluierungsergebnisse des Förderprogramms werden sowohl Bandbreite als auch Kernbereiche der entwickelten Services dargestellt. Am Beispiel des FID Erziehungswissenschaft und Bildungsforschung wird die dort vorgenommene Umsetzung der Programmvorgaben beschrieben. Abschließend wird ein Ausblick auf die Weiterentwicklung des Förderprogramms gegeben.
Assessment of cardiac risk in chronic asymptomatic alcoholics using blood pressure and electrocardiogram, and the relation with duration of drinking
Authors: Iyer Shruti , Omprakash Abirami 
Published: November 2019

Abstract

Background
The Global Status Report 2017 reveals that 11% of Indians indulge in binge drinking. Chronic alcohol intake may lead to cardiac problems and hypertension. The aim of this study was to evaluate cardiovascular risk among asymptomatic chronic alcoholics.

Methods
A total of 80 asymptomatic chronic alcoholics of South Indian origin, from the psychiatry ward of Sri Ramachandra Institute of Higher Education and Research, India were diagnosed with alcohol dependence syndrome(ADS). Group I includes alcoholics for 10 years or less and group II includes alcoholics for more than 10 years. Alcohol consumption was measured using the DSM IV criteria. Blood pressure (BP) and electrocardiographic (ECG) data were measured on admission and 2 weeks later. The paired t-test compared a significant outcome of the two sets of data at p ≤ 0.05 level of significance.

Results
Forty percent of the patients were found to be hypertensive and only 2.5% were found to be pre-hypertensive on admission. The mean age of the hypertensives was 46.9 and nonhypertensives was 42.1 The difference in the BP evaluated after 2 weeks was staggering – systolic BP had a mean fall of 6.1 mm Hg (p < 0.001) and diastolic BP 2.25 mm Hg (p = 0.001). The electrocardiogram results showed significant changes like left ventricular hypertrophy, abnormal T waves, and QT prolongation.

Conclusions
Chronic alcoholism is a major criterion for heart abnormalities such as elevated BP and left ventricular enlargement, and our study supports this as we see that alcohol consumption for more than 10 years shows significant deterioration. Further clinical observations and long-term prospective studies are needed to confirm these observations.
Das palimpsestische Selbst. Zur Genese, Struktur, Darstellung und Vermittlung von personaler Identität nach Sören Kierkegaard
Authors: Engmann Matthias 
Published: November 2019

Abstract
This article examines the subjective structure and genesis of personal identity in (some of) Kierkegaard’s pseudonymous writings. Based on a structural analysis of self-awareness (here, in particular, the category of existential becoming, the social embeddedness of the individual and the irreducible fact of mediation of personal identity), the main thesis is that, according to Kierkegaard, personal identity can best be described as a constant interweaving of hypertextual and intertextual layers. Accordingly, the central metaphor of palimpsest is used in order to account for the self-relation as an overwriting process, realized by a constant self-reinterpretation of the individual. The article focuses on certain structural, existential, hermeneutic, and semiotic key aspects of such an interpretation.
A Prompter’s Play? Kierkegaard’s Puzzling Portrait of Authorial Withdrawal in “An Occasional Discourse”
Authors: Damgaard Iben 
Published: November 2019

Abstract
Kierkegaard portrays his role as an author with the image of a prompter in “An Occasional Discourse” of 1847. A prompter in the theatre whispers not his own words, but a text by someone else already familiar to the actors on stage. This raises the question as to which text Kierkegaard is prompting. I seek to answer the question through a close reading of his imagery of authorial withdrawal in this discourse in connection with his repeated description of his writings as readings of the original text of individual human existence-relationships, the old familiar text handed down from the fathers.
Weird Allies? Kierkegaard and Object-Oriented Ontology
Authors: Wilde Niels 
Published: November 2019

Abstract
This paper examines the connection between Kierkegaard’s philosophy of existence and Graham Harman’s object-oriented ontology. The claim is that Harman’s position provides a conceptual apparatus that can beneficially address some basic ontological points in Kierkegaard about actuality, the self and the reality of individual subsisting mind-independent entities. On the other hand, Kierkegaard’s emphasis on the human self as a place situated in existence can provide a supplement to Harman’s realism which implicitly relies on topological notions. If we define an entity, in a broad sense of the term, as something in its own right irreducible to its being-in-a-relation, but we do not want to end up in a frozen universe of isolated monads, we must revisit the notion of relationality in terms of vicarious causation (Harman) or indirect communication (Kierkegaard).
“Out into the Middle of Life”: The Age of Disintegration and Ecological Perspectives in Kierkegaard’s Thought
Authors: Ryan Bartholomew 
Published: November 2019

Abstract
This essay is an attempt to link aspects of Kierkegaard’s experimental writings with new contemporary ecological perspectives which—in the act of interpenetration—are fusing philosophy, science, literature, anthropology, political thought, new economic perspectives, and visual and sound media, in order to open up new ways to live and flourish on a damaged planet—in our “age of disintegration.” I present Kierkegaard’s diagnosis of his time as “the age of disintegration” (from 1848) as something that can be connected to the contemporary socio-political conditions in late modernity, and to the new epoch on the horizon which we are now experiencing. I interpret Kierkegaard’s expression “out into the middle of life” as the kernel of Kierkegaard’s authorship of interruption and unsettling. I argue it can be implicitly included in aspects of ecological perspectives offered by innovative writers today.
Nonesuch phonemes in loanwords
Authors: Kennard Holly J. , Lahiri Aditi 
Published: November 2019

AbstractLoanwords may or may not affect the phonological system of a language. Much of the loanword literature has focused on the adaptation of “foreign” contrasts to native systems; however, there are certain cases where languages appear to have borrowed new phonemes. We argue that loanwords alone cannot introduce a new phoneme into a language unless there are special circumstances. We examine three case studies of apparently borrowed “unusual” phonemic contrasts: Swiss German initial geminates, Bengali retroflex stops, and English voiced fricatives. In each case, we find that rather than the loanwords introducing brand-new phonemes, an existing allophonic alternation has become phonemic due to a large influx of loanwords. Thus, the phonology rather than the phonetics alone – marked or otherwise – dominates the absorption of loans.
Sternenpolitik
Authors: Reidenbach Christian 
Published: November 2019

Abstract
Fontenelle’s dual role as a representative of the Modernes as well as the perpetual secretary of the French Academy of Sciences explains his hesitation in making any public statements about politics. Nevertheless, this article identifies within his best-known Conversations on the Plurality of Worlds a liberal interpretation of the heavens that is supported by the metaphorical transfer between political semantics and the field of cosmology. The idea of this liberality flourishes in the gallant dialogue between two protagonists (the marquise and the philosopher), unfolds within the context of an opening, expert scientific discourse, and is reflected through the physical description of a commerce among celestial vortices. Thus, different aspects of the political within the Conversations are examined - starting from the self-understanding of the individual all the way up to the idea of an egalitarian universe that is characterised by collective interaction.
Strafrechtliche Theorie und Praxis um 1800 als eine Herausforderung für die ›Vernunft der Literatur‹?
Authors: Schönert Jörg 
Published: November 2019

Abstract
The starting point for this article is the question of the extent to which knowledge generated and mediated by literature can supplement or modify the professional knowledge of criminal law and practice around 1800. In particular, the article looks at the genres of the criminal case study and crime story, which were popular in this period, as a field of experience for the literary-productive observation of crime and criminal law. It explores the discursive constellations for possible relations between the areas of knowledge produced by the ›professional reason of law‹ and the ›reason of literature‹. These relations are discussed with regard to (1) types of ›medial places‹ in which legal as well as literary texts on criminal matters were published, (2) the aforementioned literary genres and (3) the literary approach of so-called poetic lawyers (›lawyers as writers‹). These perspectives determine the final analyses of texts by August Gottlieb Meisner, Karl Friedrich Muchler and Paul Johann Anselm von Feuerbach.