bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of epoxy modification in asphalt mastic
Authors: Apostolidis Panos , Liu Xueyan , Marocho Paul , van de Ven Martin , Erkens Sandra , Skarpas Tom 
Published: September 2020

AbstractIn-depth understanding of the synergetic effect between the various incorporating constituents in asphalt binders (e.g., polymers, fillers) is needed to design durable paving materials with desired properties. In this research, the focus was first on the effect of the reactivity of fillers on the evolution of adhesive strength between stone aggregates and epoxy modified asphalt mastics during the epoxy polymerization. Uniaxial tensile tests were performed on different combinations of fillers and binders with and without the epoxy-based polymer, and at different modification levels. Based on the results of the tensile tests, the increase of the adhesive strength of mastic with aggregates was generally lower when reactive filler particles (i.e., hydrated lime) were added than of epoxy binders with non-reactive filler. In other words, the non-reactive fillers did not influence the adhesion process and were thus selected for the next step studies on aging. The chemo-mechanical changes of epoxy modified asphalt mastics were analysed after pressure aging vessel and oven-conditioning after various aging times by means of Fourier transform infrared spectroscopy and dynamic shear rheometer. Less sulfoxides formed and higher modulus levels were measured with increasing the epoxy polymer in mastics over oven- and PAV-aging conditions. Due to the pressure difference, the rate of modulus increases and phase angle decrease was higher when the materials were conditioned in PAV than in oven.
20-Year Comparative Survival and Mortality of Cancer of the Esophagus by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration & Selected ICD-O-3 Oncologic Phenotypes: A Systematic Review of 83,658 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.4)
Authors: Milano Anthony F. 
Published: September 2020

Objective.— To update trends in incidence, prevalence, short- and long-term survival and mortality of esophageal cancer using the statistical database of SEER*Stat 8.3.4 for diagnosis years 1973-2014 employing multiple case selection variables.
Methods.— A retrospective, population-based study using nationally representative data from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) program to evaluate 83,658 cases of esophageal cancer for diagnosis years 1973-2014 comparing multiple variables of age, sex, race, stage, grade, cohort entry time-period, disease duration, and, two histologic oncotypes. Relative survival statistics were analyzed in two cohorts: 1973-1994 and 1995-2014. Survival statistics were derived from: SEER*Stat Database: Incidence – SEER 9 Regs Research Data, November 2016 Submission (1973-2014) &lt;Katrina/Rita Population Adjustment&gt; Released April 2017 (Ref. 9). Case frequency and incidence data, derived from the SEER program, were used to design the table format and number of pages for this report.
Results.— In a total of 83,658 cases of esophageal cancer in the United States for diagnosis years 1973-2014, multiple variables of age, sex, race, stage, grade, cohort entry time-period, disease duration, and, two histologic oncotypes were compared. Mean age in males was 66.5 years, females 70.1 years, both male and female 67.2 years. Greater than 85% of incidence cases occurred between ages 55-85+ years with the zenith in males at 65-69 years (59.4%) and 70-74 years (60.5%) in females. The overall annual US death rate from 1975-2014 has slightly increased from 3.69 to 3.99 per 100,000 per year, and excess mortality remains exceedingly high. Of the 83,658 invasive cases, 82.6% were clinically staged and 79.4% were histologically graded.
Conclusions.— Relative frequency, incidence and time-trends, and the clinical, demographic and secular variables of age, sex, race, stage, grade, cohort-entry time-periods, and predominant clinical oncotypes were comparatively analyzed to provide a comprehensive medical-actuarial assessment of esophageal cancer survival and mortality in the 1973-2014 time-frame.
Unification of Different Approaches to Probabilistic Seismic Hazard Analysis
Authors: Alamilla Jorge L. , Rodriguez José A. , Vai Rossana 
Published: September 2020

ABSTRACTCornell’s, Esteva’s, and classical formulations for seismic hazard analysis are theoretically described and mathematically unified by a suitable treatment of the random ground-motion variable. Differences and connections among the schemes are discussed, allowing for a better understanding of the underpinning principles of probabilistic seismic hazard analysis. The classical formulation is equivalent to that by Esteva, and they correspond to a general scheme. Although they are mathematically equivalent, the two formulations each has its own particular approach to express the hazard rate, so results may differ. Cornell’s original scheme is a particular case of classical and Esteva’s formulation. It is also shown that intensity exceedance rates for any index of structural performance or at a particular site can be recursively transformed into exceedance rates of other intensity indexes. Formulations are invariant under such a transformation.
Very-Long-Period (VLP) Seismic Artifacts during the 2018 Caldera Collapse at Kīlauea, Hawai‘i
Authors: Flinders Ashton F. , Johanson Ingrid A. , Dawson Phillip B. , Anderson Kyle R. , Haney Matthew M. , Shiro Brian R. 
Published: September 2020

AbstractThroughout the 2018 eruption of Kīlauea volcano (Hawai‘i), episodic collapses of a portion of the volcano’s summit caldera produced repeated Mw 4.9–5.3 earthquakes. Each of these 62 events was characterized by a very-long-period (VLP) seismic signal (&gt;40  s). Although collapses in the later stage of the eruption produced earthquakes with significant amplitude clipping on near-summit broadband seismometers, the first 12 were accurately recorded. For these initial collapse events, we compare average VLP seismograms at six near-summit locations to synthetic seismograms derived from displacements at collocated Global Positioning System stations. We show that the VLP seismic signal was generated by a radially outward and upward ramp function in displacement. We propose that at local distances the period of the VLP seismic signal is solely dependent on the duration of this ramp function and the instrument transfer function, that is, the seismic VLP is an artifact of the bandlimited instrument response and not representative of real ground motion. The displacement ramp function imposes a sinc-function velocity amplitude spectrum that cannot be fully recovered through standard seismic instrument deconvolution. Any near-summit VLP signals in instrument-response-corrected velocity or displacement seismograms from these collapse events are subject to severe band limitation. Similarly, the seismic amplitude response is not flat through the low-frequency corner, for example, instrument-response-uncorrected seismograms scaled by instrument sensitivity are equally prone to band limitation. This observation is crucial when attempting to clarify the different contributions to the VLP source signature. Not accounting for this effect could lead to misunderstanding of the magmatic processes involved.
RT-EQcorrscan: Near-Real-Time Matched-Filtering for Rapid Development of Dense Earthquake Catalogs
Authors: Chamberlain Calum John , Townend John , Gerstenberger Matthew C. 
Published: September 2020

AbstractMatched-filtering (template-matching) is an effective method for detecting clustered seismicity such as aftershocks, low-frequency earthquakes, repeating earthquakes, and tectonic and volcanic swarms. Several groups have developed efficient codes implementing matched-filter methods and demonstrated that earthquake catalogs can be substantially expanded using these methods. Here, we present a near-real-time implementation of the matched-filter method, designed to be used in response to ongoing seismicity. Its near-real-time capabilities enable dense catalogs of seismicity to be constructed rapidly, providing input into real-time seismic hazard and forecasting and thus informing the earthquake response and scientific understanding. Such rapid development of detailed earthquake catalogs has similar application in volcano monitoring, monitoring of induced seismicity, and for online construction of slow-earthquake catalogs. Our software package, RT-EQcorrscan, is an open-source extension of the EQcorrscan Python package. The package can either be deployed to apply near-real-time matched-filters to a specific geographic region or sequence on a continuous basis, or configured to respond to large earthquakes or high-rate sequences by automatically starting a matched-filter run in response to these events. The system relies on, and maintains, a constantly updated template database of waveforms and event metadata, which is then queried for the specific target region. This template database can be updated while the matched-filter is running to enable the set of templates to expand in response to previous results. Multiple region-specific matched-filters can be run in parallel, allowing the system to respond to distinct trigger events.
PENGGUNAAN BAHASA MANDARIN SEBAGAI MEDIUM DAKWAH DALAM NGO DI MALAYSIA
Authors: Mat Zain Aemy Elyani , Abu Hassan Nur Aisyah , Ismail Safinah , Mu’al Siti Zahidah 
Published: September 2020

The use of Mandarin language in Dakwah is remotely practiced by Malaysians. This is because majority of Malaysians especially Muslims are more comfortable using their native language which is Malay language and English as communication language used with mad’u from various backgrounds of religion and language. In fact, there are some more likey to practice dakwah and islah amongs only Muslims. Thus, this study is about a few dakwah movements in Malaysia that using Mandarin as communication language in dakwah movements. The research methodology used is qualitative from documented or written sourceS. The findings show that Mandarin language is an appropriate and relevant medium in dakwah communication because the number of Chinese people in Malaysia is also more than the Indians. The implication of the study found that there are two aspects the using of Mandarin language in Dakwah which are as preparation to preacher or daie to deal with Chinese mad’u; Mandarin as a dakwah communication language in facing Chinese mad’u through their organized activities and programs.
Adipose Tissue Remodeling during Cancer-Associated Cachexia: Translational Features from Adipose Tissue Dysfunction
Authors: Henriques Felipe , Batista Júnior Miguel Luiz 
Published: September 2020

AbstractCancer-associated cachexia is defined by systemic inflammation, bodyweight loss, adipose tissue remodeling, and muscle wasting. Interestingly, until nowadays, the etiology for this syndrome still unclear. It is well known that multiple factors can contribute to adipose tissue remodeling, and longitudinal studies show that adipose tissue is affected early in the course of this syndrome. During cancer cachexia, adipose tissue remodeling is associated with adipocyte atrophy, impairment of fatty acid turnover, inflammation, reorganization of the extracellular matrix, and increased thermogenic gene programming of adipose tissue. Another attractive pathway is the adipose tissue lipolysis, which is the catabolic process that is leading to the breakdown of triglycerides stored in adipocytes and the release of fatty acids and glycerol. This pathway is highly involved in the adipose tissue wasting during cancer cachexia. Whole-body deletion of the genes that encode the lipolytic enzymes attenuates the effects of the syndrome on the reduction of body fat and muscle mass. These sets of changes, in addition to metabolites derived from this process, may be the initial trigger of the sequence of events that result in the remodeling and consequent dysfunction of adipose tissue during cancer cachexia. Therefore, this review aimed to investigate the main morpho-functional events that are resulting in adipose tissue remodeling in the context of cancer-associated cachexia.
OS EFEITOS DA QUARTA REVOLUÇÃO INDUSTRIAL NA DINÂMICA DO TRABALHO JURÍDICO
Authors: Del Masso Fabiano , Godoy Eduardo do Prado 
Published: September 2020

O artigo analisa a questão da influência das recentes tecnologias aplicadas ao exercício das profissões jurídicas, o que se justifica para melhor compreender, em primeiro plano, no que consistem as inovações na área jurídica, para depois concluir sobre seus reais avanços, benefícios ou prejuízos. A frequente criação de plataformas eletrônicas está impactando no aperfeiçoamento do exercício das profissões jurídicas, principalmente na otimização do tempo. A partir do referencial da quarta revolução industrial, o estudo trata da introdução e assimilação de novas tecnologias que podem colocar em risco a demanda direta por advogados. Nessa perspectiva, o artigo examina as empresas que oferecem produtos ou serviços inovadores por meio do uso de recursos tecnológicos para a área jurídica, as chamadas lawtechs ou legaltechs. Como metodologia, após um estudo inicial de caráter descritivo e explicativo, passa-se para um levantamento bibliográfico interdisciplinar com o objetivo de proporcionar fundamentos que induzam a concluir sobre os efeitos da quarta revolução industrial na dinâmica do trabalho jurídico. Uma das questões para reflexão é: a figura do profissional do direito passa a ser prescindível? Nesse sentido, parece fácil concluir, que o cenário que surge aponta para uma possível redução da demanda de profissionais jurídicos a partir do estabelecimento de tais novidades tecnológicas, que já possibilitaram, inclusive, a prestação de serviços finalísticos relacionados à prática jurídica.
PERTUMBUHAN YUWANA ABALON (Haliotis squamata) YANG DIBERI PAKAN Ulva sp. DENGAN PENGKAYAAN UREA
Authors: Farliani Iin , Diniarti Nanda , Mukhlis Alis 
Published: September 2020

ABSTRACTThis study aims to determine the effect of different concentrations of urea as a source of nitrogen in Ulva sp. on absolute growth and daily specific growth rate of abalone juvenile (Haliotis squamata) as two main parameters in the experiment. Ulva sp. is one of the feed choices given when abalone enters the juvenile phase. This research was conducted on July 22-September 16 2019 at the Aquaculture Fisheries Center, Sekotong, West Lombok. The method used in this study is an experimental method with a Completely Randomized Design (CRD) consisting of 4 treatments and 3 replications namely A (control), B (20 ppm), C (40 ppm), D (60 ppm). Results of analysis of variance (ANOVA) at 5% significance level showed (F hit F tab 5%), which means the difference in the concentration of urea in Ulva sp. provide a real influence on the growth of absolute body weight and the specific growth rate of daily body weight abalone juvenile.Keywords: Ulva sp., Haliotis squamata, growth, nitrogen.ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh kandungan konsentrasi urea yang berbeda sebagai sumber nitrogen pada Ulva sp. terhadap pertumbuhan mutlak dan laju pertumbuhan spesifik harian yuwana abalon (Haliotis squamata) sebagai dua parameter utama dalam percobaan. Ulva sp. merupakan salah satu pilihan pakan yang diberikan saat abalon memasuki fase yuwana. Penelitian ini dilaksanakan pada tanggal 22 Juli-16 September 2019 bertempat di Balai Perikanan Budidaya Laut, Sekotong, Lombok Barat. Metode yang digunakan dalam penelitian ini adalah metode eksperimental dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 3 ulangan yaitu A (kontrol), B (20 ppm), C (40 ppm), D (60 ppm). Hasil analisis sidik ragam (ANOVA) pada taraf nyata 5% menunjukkan (F hit F tab 5%) yang artinya perbedaan kandungan konsentrasi urea pada Ulva sp. memberikan pengaruh nyata bagi pertumbuhan mutlak bobot tubuh dan laju pertumbuhan spesifik harian bobot tubuh yuwana abalon.Kata Kunci: Ulva sp., Haliotis squamata, pertumbuhan, nitrogen.
The Potential Benefits of Renal Replacement Therapy in Combination with a Hemadsorption Column in Critically Ill Patients with Acute on Chronic Liver Failure
Authors: Dana Tomescu , Popescu Mihai , Liliana Gheorghe , Speranța Iacob , Simona Dima , Irinel Popescu 
Published: September 2020

Abstract
Background. Acute on chronic liver failure (AoCLF) represents a life-threatening complication of liver cirrhosis with high mortality if patients cannot be bridged to emergency liver transplantation. The aim of this study was to assess clinical and paraclinical effects of renal replacement therapy (RRT) in combination with a hemadsorption column in patients with AoCLF. Methods. Patients were included in the study after Intensive Care Unit (ICU) admission and RRT in combination with CytoSorb® was started for three consecutive sessions. Clinical and paraclinical data were recorded before the first session and after the end of the third session. 28-days mortality was also noted. Results. Fourteen patients were included in the final data analysis. The use of CytoSorb® was associated with a decrease in bilirubin levels (p = 0.03) and creatinine (p = 0.02) and an increase in urine output (p = 0.02). Although we observed a significant decrease in platelet count (p = 0.05), no haemorrhagic complications were noted. C-Reactive Protein significantly decreased after the therapy (p = 0.05), but we did not observe a similar decrease in leucocyte count (p = 0.87) or procalcitonin levels (p = 0.18). Seven patients underwent emergency liver transplantation and survival was 100% in this group. Conclusion. The use of CytoSorb® was associated with an improvement in liver and renal functions and a decrease in C - Reactive Protein. Thrombocytopenia represents the main adverse effect of the therapy, but no haemorrhagic complications were recorded. In patients that could be bridged to liver transplantation, survival was 100%. Trial registration number: NCT04511507
LncRNA SNHG16 Contributes to Tumor Progression via miR-302b-3p/SLC2A4 in Pancreatic Cancer
Authors: Xu Hao , Miao Xin , Li Xin , Chen Haofei , Zhang Bo , Zhou Wence 
Published: September 2020

Abstract
Background: It is reported that lncRNA SNHG16 is significantly highly expressed in pancreatic cancer (PC). However, the functions and mechanisms of SNHG16 are not clear. The aim of this study was to explore the effects of SNHG16 in PC.Methods: qRT-PCR analyze was applied to detect the expression levels of SNHG16, miR-302b-3p and SLC2A4 in PC tissues and cells. CCK8 and EdU assays were used to determine the proliferation of PC cells. Transwell assay were used to measure the capacities of PC cells migration and invasion. Apoptosis were evaluated by flow cytometry, and the expression of apoptosis related proteins (including Bax, Bcl-2, cleaved caspase-3 and cleaved caspase-9), which were tested by western blot. The interactions between miR-302b-3p and SNHG16 or miR-302b-3p and SLC2A4 mRNA 3’UTR were clarified by Dual luciferase reporter assay and RNA immunoprecipitation.Results: SNHG16 was significantly elevated in PC tissues and cell lines, which was associated with poor prognosis of PC patients. Knockdown of SNHG16 reduced PC cells proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. And miR-302b-3p targeted SLC2A4 directly. Conclusions: SNHG16 promoted the progression of PC via miR-302b-3p/SLC2A4 axis and was expected to be a potential target for early diagnosis and treatment of PC.
Inferences from dysregulated long non-coding RNA-mediated competing endogenous RNAs in various chemotherapy drugs and evaluation of drug response in breast cancer
Authors: Zhang Ziwen , Li Dongbo , Zhang Han , Qin Qi , Zhang Qingyuan 
Published: September 2020

Abstract
Backgroud: Differences in individual drug response, especially drug resistance, present an obstacle to the treatment of breast cancer (BRCA). Thus, the ability to predict drug response would contribute to developing novel treatment strategies. Accumulating evidence have suggested that tumor molecular profiles and drug response data provide opportunities and challenges for the discovery of new molecular characteristics and mechanisms of drug response in BRCA. Methods: In the present study, an integrated pipeline was developed to explore drug response-related long non-coding RNA (lncRNA)-mediated competing endogenous RNAs (ceRNAs) motifs in BRCA. Results: Drug response-specific ceRNAs indicated that lncRNAs play an essential role in various drug treatments for BRCA. Several key drug-resistant and -sensitive dysregulated ceRNAs were identified in Adriamycin, Cytoxan, and Tamoxifen. The interactions in these ceRNAs showed strong correlations in BRCA. Most drug response-related dysregulated ceRNAs were only present in one kind of drug. A number of drug response-related ceRNAs presented diverse dysregulation patterns. We also extracted some key drug response-related lncRNAs, such as HCP5 and FAM182A. These lncRNAs were associated with certain cancer hallmarks and survival in BRCA. Conclusions: Ultimately, understanding the underlying lncRNA-mediated ceRNAs in drug responses will facilitate improved individual reactions to chemotherapy and overall outcomes of BRCA treatment.
Clinicopathological Features and Clinical Outcomes of Primary Hepatic Gastrointestinal Stromal Tumors: Evaluation of a Pooled Case Series
Authors: Xu Xing , Zheng Guoliang , Zheng Zhichao 
Published: September 2020

Abstract
Background: Due to the extremely rare incidence, data of clinicopathological features and prognosis of primary hepatic gastrointestinal stromal tumors (GISTs) is limited. Methods: 36 cases of hepatic GISTs were from the literature, PUBMED, EMBASE, China National Knowledge Infrastructure and WANFANG DATA, and 1 case came from our center. Clinicopathological features and outcomes were analyzed between 37 hepatic GISTs and 254 gastric GISTs from our center. Results: A majority of hepatic GISTs exceeded 5 cm (83.7%), displayed mixed density (69.4%) and spindle morphology (74.2%) and were classified as high risk (91.4%). Larger tumors of hepatic GISTs were likely to display mixed lesion and tumors with mixed lesion were prone to be classified as high risk. In comparisons to gastric GISTs, hepatic GISTs differed from gastric GISTs in tumor size, main symptoms, histologic type, mitotic index, CD34 expression, NIH risk classification. In patients with hepatic GISTs, 5-year DFS and DSS rates were 19.4% and 53.7%, which were worse than that of gastric GISTs (P＜ 0.001), especially for those with tumor size exceeding 5 cm or mitotic indices exceeding 5/50 HPF (P < 0.001). Multivariable analysis showed location and NIH risk classification were independent prognostic factors for DFS in patients with GISTs, and size and location were significantly associated with DSS. Conclusions: Hepatic GISTs distinguished from gastric GISTs in respect to clinicopathological features and outcomes. Mitotic index exceeding 5/50 HPF or tumor size exceeding 5 cm may be important factor to distinguish hepatic GISTs from gastric GISTs in DFS and DSS.