bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflatable Indian travel pillow as a pneumatic patient jack
Authors: Gopalakrishna A , Agrawal Karoon 
Published: January 2020

AbstractThe Indian travel pillow readily available in the market has been utilized as a patient jack in the operation theatre. This has been used to raise the shoulders of an anaesthetized patient for surgery in the head and neck region and a set of two pillows have been used to prop-up a prone anaesthetized patient. This allows smooth positioning of the patient after intubation without disturbance to the airway with minimal manpower.
A technique for introducing looped sutures in flexor tendon repair
Authors: Jagannath Kamath B , Praveen Bhardwaj 
Published: January 2020

ABSTRACTStronger flexor tendon repairs facilitate early active motion therapy protocols. Core sutures using looped suture material provide 1 ½ to twice the strength of Kessler′s technique (with four strand and six strand Tsuge technique respectively). The technique is well-described and uses preformed looped sutures (supramid). This is not available in many countries and we describe a technique whereby looped sutures can be introduced in flexor tendon repair by the use of 23 G hypodermic needle and conventional 4.0 or 5.0 sutures. This is an alternative when the custom made preformed sutures are not available. This can be practiced in zone 3 to zone 5 repairs. Technical difficulties limit its use in zone 2 repairs.
A simple novel technique for closure of simple and complex pilonidal sinus with either simple (tongueshaped) or bilobed rotation fl ap
Authors: Mohamed M.S. Awad , Mohamed Tolba , Osama H. Gharib 
Published: January 2020

ABSTRACT
Background:Pilonidal sinus is a common disease in young adults that carries high postoperative morbidity and patients′ discomfort; controversy still exists regarding the best surgical technique for the treatment of the disease. We successfully treat it with a rotation flap technique (simple rotation and bilobed rotation flap).Materials and Methods: Sixty-two patients were randomized to receive surgical treatment in the form of either simple rotation or bilobed rotation flap by eccentric elliptical excision of the diseased tissues down to the sacral fascia and closure of the defect with the flap, then placing a closed suction drain at the base of the wound, with its tip being brought out in the gluteal region at least 5 cm laterally to the lower end of the suture. Results: All our patients healed completely without recurrence after a mean follow-up of about one year. Mean hospital stay 1.5 days (range 1-3) Mean time to complete healing 11.9 days (range 8-14). Mean time off work was 11.5 days (range 10-21), wound infection and breakdown, three (4.8%), recurrence (0%), and time to sitting on the toilet and walking without pain was 10-15 days.Conclusions: A tension-free suture and cleft left via the rotation flap, either the bilobed flap or monolobed, is the key to success without recurrence and low patient discomfort.
An arteriovenous fi stula following chalazion excision
Authors: Yuri A.R. Dias-Amborcar , Nitin J. Mokal , Suhas V. Abhyanka , Uday B. Bhat 
Published: January 2020

ABSTRACTAn arteriovenous fistula secondary to a chalazion is a rare occurrence. It may follow spontaneous necrosis or surgical trauma. Digital subtraction angiography and identification of the arterial feeders combined with direct puncture of the nidus and embolization is recommended, as surgical excision becomes much easier and results in a complete excision of the lesion. Conchal cartilage graft is a useful lining material for reconstruction of the tarsal plate due to its natural curvature. It restores lid integrity and ensures a stable and functional eyelid.
Munchausen′s syndrome in plastic surgery practice: A bewildering situation!
Authors: Nardella D , Sohawon M S , Heymans O 
Published: January 2020

ABSTRACTThe plastic surgeon rarely encounters patients expressing factitious disorders. Through their incredible imagination, these patients conjure numerous lesions for themselves and willingly accept to undergo invasive diagnostic procedures and risky therapies. We report four cases of Munchausen′s syndrome in the field of plastic surgery and follow with a discussion of as to when should the alarm bells start ringing for the unsuspecting plastic surgeon, to assist him in dealing with these too often-ignored disorders.
Lipofibromatous hamartoma of the median nerve: A case report and review of the literature
Authors: Patil V. S. , Nagle Sunila 
Published: January 2020

ABSTRACTA case of lipofibromatous hamartoma of the median nerve in an adult is described in this article. A 33-year-old male presented with tingling, numbness and swelling in the palm of the left non dominant hand that had been present for a few months. Examination revealed that there was fullness in the volar aspect of the wrist and in the inter-thenar area. Another mass was present at the base of the index finger, which appeared to be involving subcutaneous tissues. The clinical diagnosis was carpal tunnel syndrome due to a space occupying tumor mass in the carpal tunnel. On exploration of the carpal tunnel, a large median nerve was seen 4 cm proximal to the wrist crease line and extending distally until it divided into its branches. Another mass was present at the base of the index finger, which was adherent to the skin. The radial digital nerve of the index finger was normal in size. For the enlarged nerve, an epineurotomy was performed and a biopsy was taken. Another biopsy was taken from the distal mass. His postoperative period was uneventful. In July 2004, at the end of 5 years, the patient had no symptoms and the size of the tumor had not increased.
Aplasia cutis congenita: Two cases of non-scalp lesions
Authors: Abulezz Tarek A. , Shalkamy Mahmoud A. 
Published: January 2020

ABSTRACTAplasia cutis congenita (ACC) is a rare condition characterized by a localized absence of skin and in some cases, the subcutaneous tissues. The majority of cases occur in the scalp; however, the lesion may occur anywhere in the trunk and extremities. ACC is most often an isolated defect, but it can be associated with other anomalies. Most reported cases are sporadic with a few reports of familial occurrence. Neither the pathogenesis nor the aetiology is clarified. Healing is spontaneous in most cases, and apart from keeping the lesion clean, no specific treatment is required. In this report, two cases of non-scalp ACC occurring in the lower limbs are presented and a brief review of the literature is conducted.
Peroperative evaluation of vascularity of various flaps by fluorescein technique
Authors: Bhattacharya V , Sunish Goyal , Nepram Sanjib Singh , Manihar H Singh , Sheikh Adil Bashir 
Published: January 2020

Abstract
Background: The viability of any pedicled flap depends upon its vascularity. When a flap is dissected it becomes relatively ischaemic. Ultimately, the viability of the flap depends on the vessels incorporated in the pedicle and their perfusion capacity. There are different techniques to evaluate the blood supply of a flap.
Aims: This study deals with experimental and clinical efficiency of fluorescein dye technique to evaluate the vascularity of flaps of various compositions.
Materials and Methods: The experimental study was conducted on rats to standardize the technique. Thereafter clinical evaluation was conducted for different flaps namely fasciocutaneous, skeletonized perforator based fasciocutaneous, adipofascial, fasciocutaneous flap with adipofascial extension, fasciocutaneous flap with fascial extension and fasciocutaneous flap with split fascial extension.
Conclusions: The paper deals in detail with the technique and method of documentation of a fluorescein study on flaps both experimentally and clinically. The appearance of fluorescein on both the surfaces and distal margin of the flap confirmed the adequacy of vascularity soon after dissection of the flaps. It was found to be an easy, safe and reliable objective method.
The effect of tissue expanders on the growing craniofacial skeleton
Authors: Mohamed MS Awad 
Published: January 2020

Abstract
Background: Tissue expansion can safely be considered one of the major advances in reconstructive plastic surgery. Reported complication rates for tissue expansion have been as low as zero and as high as 48% when expanding the head and neck region in pediatric patients.[1] Our study is to discuss the osseous effects during and after tissue expansion in children.
Materials and Methods: Thirty four expanders were implanted, 30 in scalp and 4 in face. In 4 patients, 2 expanders were used. The mean age of the patients was 3.8 years. All CT examinations (pre-expansion, post-expansion and after reconstruction) were done correspondingly with each other to be able to compare the following parameters: bone thickness and bone density under the expander; certain intracranial dimensions under the center and the edge of the expander and observing the contour of the skull in the 3D reconstruction.Results: Variable bony changes were observed in the 30 patients, apposition at the edge of expander (Periosteal reaction) being the most frequent change, which was observed in, all except 3 patients. Bone resorption and thinning occurred in 9 patients. Inward bone displacement varied from 1 to 3 mm in two patients. Conclusions: In spite of the reported complications like thinning and deformation of underlying bone, expansion in infants and children is safe if done with a proper preoperative planning and we prefer to delay the expansion after two years as possible.
Management of acute open tendo-achilles injuries in Indian lavatory pans
Authors: Sasanka S Chatterjee , Arindam Sarkar , Ashutosh Misra 
Published: January 2020

AbstractInjuries to the Tendo-achilles are common but rarely do they present directly to plastic surgeons. Eighteen patients with acute tendo-achilles injury due to fall in the lndian type of lavatory pan came directly to the emergency department of Institute of Post Graduate Medical Education and Research, Kolkata and subsequently were treated in the Department of Plastic Surgery. Direct repair with prolene or stainless steel (SS) wires with or without flap cover were performed for management. Exercises were started 1 month later with gradual increase in activity. Complications were minor and temporary in nature. Long term results in the form of performing previous activities were excellent.
Nutrition in burns: A practical solution to a difficult problem
Authors: Suri M P , Patel C K , Dhingra VJ S , Raibagkar S C , Mehta D R 
Published: January 2020

AbstractThe nutritional aspects of burns is an important but yet not properly looked after problem in the management of burns. We present our experience with dealing with such a problem giving a practical and easy to deliver solution to nutrition. Early enteral nutrition should be started with frequent assessment to the need of the patient and it requires a team approach.
The Role of Combined Therapy in the Treatment of Retinopathy and Optic Neuropathy Due to Radiotherapy in the Uveal Melanoma
Authors: Cihan Yasemin Benderli 
Published: January 2020

Introduction Uveal melanoma has a relatively low incidence. Transpupillary thermotherapy (TTT), hypofractioned stereotactic radiotherapy (RT), stereotactic radiosurgery, plaque brachytherapy, charged particle radiation therapy, local tumor resection, enucleation, and exantation are applied in the treatment.
Methods The importance given to radiotherapy has increased to get more satisfactory results while treating the patient. However, it is the treatment of radiation retinopathy and optic neuropathy from complications.
Results Radiation retinopathy and optic neuropathy are the most important complications related to radiotherapy in the treatment of uveal melanoma. In recent years, many studies have been performed on the treatment of radiation retinopathy and optic neuropathy.
Conclusion The consecutive use of triamcinolone in combination with anti-VEGF supports that it may be a future therapeutic agent in the treatment of complications.
汉语自然会话转换型回应及其互动功能
Authors: Xie Xinyang 
Published: January 2020

摘要
本文对汉语自然口语会话中的转换型回应进行探讨，将转换型回应划分为措辞转换型回应和规程转换型回应两类。就汉语自然口语而言，措辞转换型回应在互动中的主要功能在于答者希望提供更为准确和足量的信息，形式上大部分是单小句或短语形式。规程转换型回应则基本上是多小句的形式，而且一般都会带来序列上的扩展。
Modes of Delivery in Concurrent Nicotine and Cannabis use (“Co-Use”) among Youth: Findings from the International Tobacco Control (ITC) Survey
Authors: Smith Danielle M. , Miller Connor , O'Connor Richard J. , Kozlowski Lynn T. , Wadsworth Elle , Fix Brian V. , Collins R. Lorraine , Wei Binnian , Goniewicz Maciej L. , Hyland Andrew J. , Hammond David 
Published: January 2020

Background Cannabis use is more common among nicotine users than non-users. This study characterized concurrent use of nicotine and cannabis (“co-use”) among 12,064 youth aged 16–19 years residing in Canada, the United States, and England in 2017. Methods Data were from the ITC Youth Tobacco & Vaping Survey (Wave 1). Seven modes of cannabis delivery (MOD) were characterized by country of residence and past 30-day use of combusted tobacco and electronic cigarettes. Weighted multivariable regression models were fitted to assess the correlates of co-use and each cannabis MOD. Results Seventy percent of cannabis users reported nicotine use. Co-users exhibited behavioral and demographic differences compared to exclusive users of either substance. “Smoking cannabis without tobacco” was the most popular form of use (78%). Use of nicotine-containing e-cigarettes was associated with “using an e-cigarette to vape cannabis oil/liquid” (aOR: 4.96, 95%CI: 2.23–11.06). Combustible tobacco use was associated with “smoking cannabis with tobacco in a joint/blunt” (aOR: 2.93, 95%CI: 1.89–4.56). Country-level differences were detected. Conclusions Nicotine use is substantial among cannabis users, and associations exist between modes of delivery for both drugs. Results underscore the importance of studying cannabis and nicotine use concurrently, and the need to address the use of both substances in developing interventions for youth users.
Ghost network analyzer
Authors: Zhang Xiao , Yin He , Li Rui , Hong Jiaying , Li Qin , Xue Ping 
Published: January 2020

Abstract
Ghost imaging obtains an image of an amplitude/phase object by spatial correlation between two separated light beams. In ghost imaging, two detectors are used in a counter-intuitive way. One is a multi-pixel detector that does not view the object in reference arm, and the other one is a single-pixel detector that does view the object but only record the total light power in object arm. Neither detector could recovery the object independently, but spatial correlation from two detectors allows the reconstruction of a ghost image of the object. Here for the first time we present ghost network analyzer for obtaining frequency properties of a target. Interestingly, this novel technique proves insensitive to the distortion introduced by nonlinear devices, while conventional frequency-domain measurement modalities such as network analyzer can hardly work properly with distortion. The proposed technique provides a breakthrough method for distortion-free dynamic frequency response analysis.
The Association Between Unemployment and Mortality: A Cohort Study of Workplace Downsizing and Closure
Authors: Junna Liina , Moustgaard Heta , Huttunen Kristiina , Martikainen Pekka 
Published: January 2020

Abstract
Workplace downsizing and closure have been considered natural experiments that strengthen causal inference when assessing the association between unemployment and health. Selection into unemployment plays a lesser role among those exposed to severe workplace downsizing. This study compared mortality for individuals unemployed from stable, downsized, and closed workplaces with a reference group unexposed to unemployment. We examined nationally representative register data of residents of Finland aged 25–63 years in 1990–2009 (n = 275,738). Compared with the control group, the hazard ratio for substance use–related mortality among men unemployed from stable workplaces was 2.43 (95% confidence interval (CI): 2.22, 2.67), from downsized workplaces 1.85 (CI: 1.65, 2.08), and from closed workplaces 2.16 (CI: 1.84, 2.53). Among women, the corresponding estimates were 3.01 (CI: 2.42, 3.74), 2.39 (CI: 1.75, 3.27), and 1.47 (CI: 1.09, 1.99). Unemployment from stable workplaces was associated with mortality from psychiatric and self-harm–related conditions. However, mortality due to ischemic heart disease and other somatic diseases decreased for those unemployed following closure. The results indicate that selection mechanisms partially explain the excess mortality among the unemployed. However, substance-use outcomes among men and women, and fatal accidents and violence among men, might be causally associated with unemployment.
Program development of a preceptor bootcamp for operational pharmacy preceptors
Authors: Smith Devlin V , Gautreaux Stefani , Gulbis Alison M , Bruno Jeffrey J , Garey Kevin , Roux Ryan K , Varkey Divya 
Published: January 2020

AbstractPurposeTo describe the development, design, and implementation of a pilot preceptor development bootcamp and feedback related to its feasibility and impact on operational pharmacy preceptors.SummaryThe University of Texas MD Anderson Cancer Center designed and implemented a pilot preceptor development bootcamp for operational staff pharmacists serving as residency preceptors for longitudinal weekend staffing experiences. A systematic, multipronged approach was taken to identify preceptor development gaps and design a full-day bootcamp curriculum. The resultant curriculum was comprised of content in major functional areas including using the 4 preceptor roles, documenting performance, giving and receiving feedback, and dealing with difficult situations or learners. The impact of the pilot preceptor development bootcamp was assessed using survey methodology and qualitative feedback from debrief discussions.ConclusionImplementation of a pilot preceptor bootcamp program addressing major areas of precepting skill was well received, resulted in positive feedback from operational pharmacy preceptors, and was feasible to implement at a large academic medical center.
Sex, synchrony, and skin contact: integrating multiple behaviors to assess pathogen transmission risk
Authors: Leu Stephan T , Sah Pratha , Krzyszczyk Ewa , Jacoby Ann-Marie , Mann Janet , Bansal Shweta 
Published: January 2020

Abstract
Direct pathogen and parasite transmission is fundamentally driven by a population’s contact network structure and its demographic composition and is further modulated by pathogen life-history traits. Importantly, populations are most often concurrently exposed to a suite of pathogens, which is rarely investigated, because contact networks are typically inferred from spatial proximity only. Here, we use 5 years of detailed observations of Indo-Pacific bottlenose dolphins (Tursiops aduncus) that distinguish between four different types of social contact. We investigate how demography (sex and age) affects these different social behaviors. Three of the four social behaviors can be used as a proxy for understanding key routes of direct pathogen transmission (sexual contact, skin contact, and aerosol contact of respiratory vapor above the water surface). We quantify the demography-dependent network connectedness, representing the risk of exposure associated with the three pathogen transmission routes, and quantify coexposure risks and relate them to individual sociability. Our results suggest demography-driven disease risk in bottlenose dolphins, with males at greater risk than females, and transmission route-dependent implications for different age classes. We hypothesize that male alliance formation and the divergent reproductive strategies in males and females drive the demography-dependent connectedness and, hence, exposure risk to pathogens. Our study provides evidence for the risk of coexposure to pathogens transmitted along different transmission routes and that they relate to individual sociability. Hence, our results highlight the importance of a multibehavioral approach for a more complete understanding of the overall pathogen transmission risk in animal populations, as well as the cumulative costs of sociality.
Curation and annotation of planarian gene expression patterns with segmented reference morphologies
Authors: Roy Joy , Cheung Eric , Bhatti Junaid , Muneem Abraar , Lobo Daniel 
Published: January 2020

Abstract

Motivation
Morphological and genetic spatial data from functional experiments based on genetic, surgical and pharmacological perturbations are being produced at an extraordinary pace in developmental and regenerative biology. However, our ability to extract knowledge from these large datasets are hindered due to the lack of formalization methods and tools able to unambiguously describe, centralize and interpret them. Formalizing spatial phenotypes and gene expression patterns is especially challenging in organisms with highly variable morphologies such as planarian worms, which due to their extraordinary regenerative capability can experimentally result in phenotypes with almost any combination of body regions or parts.

Results
Here, we present a computational methodology and mathematical formalism to encode and curate the morphological outcomes and gene expression patterns in planaria. Worm morphologies are encoded with mathematical graphs based on anatomical ontology terms to automatically generate reference morphologies. Gene expression patterns are registered to these standard reference morphologies, which can then be annotated automatically with anatomical ontology terms by analyzing the spatial expression patterns and their textual descriptions. This methodology enables the curation and annotation of complex experimental morphologies together with their gene expression patterns in a centralized standardized dataset, paving the way for the extraction of knowledge and reverse-engineering of the much sought-after mechanistic models in planaria and other regenerative organisms.

Availability and implementation
We implemented this methodology in a user-friendly graphical software tool, PlanGexQ, freely available together with the data in the manuscript at https://lobolab.umbc.edu/plangexq.

Supplementary information
Supplementary data are available at Bioinformatics online.
Inference of gene regulatory networks based on nonlinear ordinary differential equations
Authors: Ma Baoshan , Fang Mingkun , Jiao Xiangtian 
Published: January 2020

Abstract

Motivation
Gene regulatory networks (GRNs) capture the regulatory interactions between genes, resulting from the fundamental biological process of transcription and translation. In some cases, the topology of GRNs is not known, and has to be inferred from gene expression data. Most of the existing GRNs reconstruction algorithms are either applied to time-series data or steady-state data. Although time-series data include more information about the system dynamics, steady-state data imply stability of the underlying regulatory networks.

Results
In this article, we propose a method for inferring GRNs from time-series and steady-state data jointly. We make use of a non-linear ordinary differential equations framework to model dynamic gene regulation and an importance measurement strategy to infer all putative regulatory links efficiently. The proposed method is evaluated extensively on the artificial DREAM4 dataset and two real gene expression datasets of yeast and Escherichia coli. Based on public benchmark datasets, the proposed method outperforms other popular inference algorithms in terms of overall score. By comparing the performance on the datasets with different scales, the results show that our method still keeps good robustness and accuracy at a low computational complexity.

Availability and implementation
The proposed method is written in the Python language, and is available at: https://github.com/lab319/GRNs_nonlinear_ODEs

Supplementary information
Supplementary data are available at Bioinformatics online.