bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive framing modulates emotional processing through dorsolateral prefrontal cortex and ventrolateral prefrontal cortex networks: A functional magnetic resonance imaging study
Authors: Kirk Ulrich , Lilleholt Lau , Freedberg David 
Published: August 2020

AbstractIntroductionIn this study, we show new evidence for the role of ventrolateral prefrontal cortex‐dorsolateral prefrontal cortex (VLPFC‐DLPFC) networks in the cognitive framing of emotional processing.MethodWe displayed neutral and aversive images described as having been sourced from artistic material to one cohort of subjects (i.e., the art‐frame group; n = 19), while identical images, this time identified as having been sourced from documentary material (i.e., the doc‐frame group; n = 20) were shown to a separate cohort.ResultsUsing functional magnetic resonance imaging (fMRI), we employed a linear parametric model showing that relative to the doc‐frame group the art‐frame group exhibited a modulation of amygdala activity in response to aversive images. The attenuated amygdala activity in the art‐frame group supported our hypothesis that reduced amygdala activity was driven by top‐down DLPFC inhibition of limbic responses. A psychophysiological interaction (PPI) analysis demonstrated that VLPFC activity correlated with amygdala activity in the art‐frame group, but not in the doc‐frame group for the contrast [Aversive > Neutral].ConclusionThe role of the VLPFC in cognitive control suggests the hypothesis that it alongside DLPFC insulates against embodied emotional responses by inhibiting automatic affective responses.
How and when environmental orientation drives corporate sustainable development in a cross‐national buyer–supplier dyad
Authors: Chan Ricky Y.K. , Ma Katherine H.Y. 
Published: August 2020

AbstractThis study aims at relating the role of environmental orientation to corporate sustainable development within a cross‐national buyer–supplier dyad. To this end, it specifically proposes and empirically tests a model delineating how the international buyer's environmental orientation would influence its green supplier development (GSD) activities, then its outsourcing supplier's green product strategies (GPS), and finally total relationship value (TRV) of the entire buyer–supplier dyad. It also examines how supplier overall information technology advancement (SOITA) would further moderate the aforementioned influences. Survey results derived from 202 buyer–supplier dyads have provided empirical support for all the hypothesized relationships of the proposed model. To summarize, the findings show that international buyers' internal and external environmental orientations both serve as a major driver for their GSD, which, in turn, significantly advances outsourcing suppliers' practice of GPS and consequently enhances TRV. Moreover, this study has demonstrated that SOITA exerts a significant and positive moderating effect on the GSD–GPS link. Overall, this study provides important insights into understanding the complex and contingent processes underlying the influence of the international buyer's environmental orientation on the joint performance of the dyad.
Effect of using a nitrogen atmosphere on enzyme hydrolysis at high corn stover loadings in an agitated reactor
Authors: dos Santos Antonio Carlos Freitas , Ximenes Eduardo , N. Thompson David , Ray Allison E. , Szeto Ryan , Erk Kendra , Dien Bruce S. , Ladisch Michael R. 
Published: August 2020

AbstractA comprehensive review of the literature shows that enzyme hydrolysis efficiency decreases with increased solids loadings at constant enzyme:cellulose ratios for pretreated lignocellulosic substrates. In seeking a mechanistic explanation for this phenomenon, we found that a nitrogen atmosphere enhances enzyme hydrolysis and minimizes the decrease in glucose yields as solids loadings are increased in an agitated bioreactor. For liquid hot water pretreated corn stover, at solids loadings of both 100 and 200 g/L and hydrolyzed for 72 hr in a 1 L bioreactor at pH 5.0 with 3.6 mg protein per g biomass, glucose yields were 55% in a nitrogen atmosphere versus 45% in air with agitation and about 34% without agitation. While mixing promotes biomass/enzyme contact and disperses sugars released during hydrolysis that would otherwise cause product inhibition, nitrogen gas displaces air, avoiding deactivation of cellulases by oxygen. The nitrogen effect points to a facile approach of enhancing hydrolysis at high solids loadings.
The dose‐effect model is good enough
Authors: Schuler Keke , Kilmer Elizabeth D. , Callahan Jennifer , Dziurzynski Kristan , Swift Joshua 
Published: August 2020

AbstractAlthough there is wide agreement on the general efficacy of psychotherapy, two prominent models on the trajectories of change in psychotherapy over time, the dose‐effect (DE) model and the good‐enough level (GEL) model, indicate competing trajectories of change. According to the DE model, the course of treatment follows the shape of a negatively accelerating curve, even though each session of psychotherapy is conceptualised as providing an equivalent dose of treatment. In contrast, the GEL model suggests that there is a linear relationship between psychotherapy response and treatment length that is idiographic for each client, depending on the number of sessions attended. The aim of the current study was to compare these two models in a sample of 399 adult psychotherapy clients. Session‐by‐session outcome was tracked using the Outcome Questionnaire‐45.2 in tandem, and multilevel modelling was used for the analyses. Results indicate that the DE model fits the data better than the GEL model, although the difference in model fit was small. Support for the DE model over the GEL model was further evident in a subsample of prototypical clients—that is, those who did not experience problems with the therapeutic alliance, social support or stressful life events. Findings from the present study add to the existing literature comparing the DE and GEL models and have implications on outcome monitoring in psychotherapy services.
Effects of barley β‐glucan with various molecular weights partially hydrolyzed by endogenous β‐glucanase on glucose tolerance and lipid metabolism in mice
Authors: Mio Kento , Yamanaka Chiemi , Ichinose Yasunori , Kohyama Noriko , Yanagisawa Takashi , Aoe Seiichiro 
Published: August 2020

AbstractBackground and objectivesIn this study, we investigated whether the intake of a high‐fat diet containing barley β‐glucan partially hydrolyzed by endogenous β‐glucanase (PHEB) for 2 or 8 hr affects glucose metabolism, lipid metabolism, and intestinal microbiota compared with untreated barley (BF) and a control diet in mice.FindingsA significant increase in cecum weight was observed in all barley groups compared with the control group. Liver lipid accumulation was significantly decreased in all barley groups. In mice given barley flour hydrolyzed for 8 hr (PHEB‐8h), blood glucose levels tended to decrease at 30 min when compared with the control group (p = .06). Total short‐chain fatty acids (SCFA) contents in the cecum were significantly increased in the BF and PHEB groups compared with the control group.ConclusionsWe demonstrated that the improving effects of barley β‐glucan on glucose and lipid metabolism were maintained even after partial hydrolysis, whereas the effects of barley β‐glucan on intestinal microbiota and SCFA production were moderately changed by partial hydrolyzation.Significance and noveltyThe findings of this study showed that, even after the cooking process, partially hydrolyzed barley β‐glucan is expected to improve glucose and lipid metabolism, similar to intact barley β‐glucan.
Electrochemical Properties and Kinetics of Asymmetric Sodium Benzene‐1,2,4‐tricarboxylate as an Anode Material for Sodium‐Organic Batteries
Authors: Gu Tiantian , Gao Shu , Wang Juan , Cao Shengling , Wang Kangli , Zhou Min , Jiang Kai 
Published: August 2020

AbstractOrganic carboxylates are well‐accepted as low‐cost anodes for sodium‐ion batteries, owing to their abundant natural resources, structural versatility and suitable potentials. In this work, sodium benzene‐1,2,4‐tricarboxylate (Na‐1,2,4‐BTC), featured as an asymmetric carboxylic‐based coordination salt, is studied as a Na storage anode. The sodium ions exhibit diffusion‐controlled behavior involving the enolization of the C=O groups in Na‐1,2,4‐BTC. Meanwhile, benefiting from its robust organic‐metal coordination framework and fast charge transfer properties, the as‐prepared Na‐1,2,4‐BTC delivers a high initial desodiation capacity of 258 mA h g−1, outstanding rate capability at 2 A g−1 and remarkable cyclability over 500 cycles, demonstrating a great potential as Na‐organic battery anode with high performance and low cost.
The function of SEC22B and its role in human diseases
Authors: Sun Wei , Tian Bi‐Xia , Wang Shu‐Hong , Liu Pei‐Jun , Wang Yao‐Chun 
Published: August 2020

AbstractSoluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) proteins are a large protein complex that is involved in the membrane fusion in vesicle trafficking, cell growth, cytokinesis, membrane repair, and synaptic transmission. As one of the SNARE proteins, SEC22B functions in membrane fusion of vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus, antigen cross‐presentation, secretory autophagy, and other biological processes. However, apart from not being SNARE proteins, there is little knowledge known about its two homologs (SEC22A and SEC22C). SEC22B alterations have been reported in many human diseases, especially, many mutations of SEC22B in human cancers have been detected. In this review, we will introduce the specific functions of SEC22B, and summarize the researches about SEC22B in human cancers and other diseases. These findings have laid the foundation for further studies to clarify the exact mechanism of SEC22B in the pathological process and to seek new therapeutic targets and better treatment strategies.
Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells
Authors: Chen Wenmin , Hu Shuai , Mao Shuai , Xu Yibin , Guo Hui , Li Haoxi , Paulsen Michelle T. , Chen Xinde , Ljungman Mats , Neamati Nouri 
Published: August 2020

AbstractMitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti‐cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) group to design Mito‐Chlor, a novel agent that acts on mitochondria DNA (mtDNA). Herein, we show that Mito‐Chlor, but not chlorambucil, inhibits the nascent transcription of mtDNA. Clustering analysis of transcriptomic profile of our Bru‐seq database led to the identification of another mitochondrial transcription inhibitor SQD1, which inhibits the proliferation of MIA PaCa‐2 cells with an IC50 of 1.3 μM. Interestingly, Mito‐Chlor reduces expression of mitochondrial proteins, interferes with mitochondria membrane potential, and impairs oxidative phosphorylation while SQD1 does not. Both compounds increased cellular and mitochondrial reactive oxygen species and stimulated similar signaling pathways in response to oxidative stress. As mitochondrial transcription inhibitors and redox modulators, SQD1 and Mito‐Chlor are promising for the treatment of pancreatic cancer by blocking mitochondrial function.
Applications of Carbon Dots in Next‐generation Lithium‐Ion Batteries
Authors: Song Tian‐Bing , Huang Zun‐Hui , Niu Xiao‐Qing , Liu Jun , Wei Ji‐Shi , Chen Xiao‐Bo , Xiong Huan‐Ming 
Published: August 2020

AbstractLithium‐ion battery (LIB) is a dominating power source in the market owing to its high energy density, good cycling stability and environmental benignity. However, technical challenges remain after years’ optimization and commercialization, which are detrimental to the expected performance and lifespan of LIBs. For instance, many cathode materials of LIBs suffer from rapid capacity fading and poor high‐rate performance, which are ascribed to self‐aggregation, dissolution and fast increased charge transfer resistances during cycles. In terms of the anode materials, low coulombic efficiency, electrolyte depletion and safety issues are common. In addition, the liquid electrolyte systems trigger safety concerns because flammable and volatile organic solvents are necessary. Recently, carbon dots (CDs) emerge as a sound material to address those challenges of LIBs, and also present promising applications in bioimaging, fluorescence sensing, photo/electro‐catalysis, and electroluminescence. This review will overlook the state‐of‐the‐art advances in the employment of CDs based composites to build cathode/anode materials and electrolytes in LIBs, through tailoring the internal structures and the surface states of electrode materials, and being additives in electrolyte, to improve the performances of the next‐generation LIBs. The major challenges and opportunities in front of CDs in LIBs will be outlined and discussed in detail.
Safety, Tolerability, and Dose Proportionality of a Novel Transdermal Fentanyl Matrix Patch and Bioequivalence With a Matrix Fentanyl Patch: Two Phase 1 Single‐Center Open‐Label, Randomized Crossover Studies in Healthy Japanese Volunteers
Authors: Lorch Ulrike , Pierscionek Tomasz , Freier Anne , Spencer Christopher S. , Täubel Jörg 
Published: August 2020

AbstractTwo open‐label, single‐dose, randomized crossover studies were conducted in healthy Japanesemen to (1) assess dose proportionality of 5 doses (1.38, 2.75, 5.5, 8.25, and 11.0 mg) of Lafenta, a novel matrix‐type transdermal fentanyl patch with a rate‐controlling membrane; and (2) compare patch bioequivalence (11.0 mg) with a commercially available reference patch (Durotep MT Patch [16.8 mg]). Pharmacokinetics, adhesion performance, residual fentanyl, and safety parameters were assessed. Increases in mean AUC0‐t and Cmax after application of the test patch were dose proportional. The test patch (11.0 mg) was bioequivalent to the 16.8‐mg reference patch in terms of mean AUC0‐inf, AUC0‐t, and Cmax. Residual fentanyl levels 72 hours postapplication were lower in the test than in the reference patch. Differences in adhesion performance between the test and the reference patch did not affect delivery efficacy and reliability of the novel matrix patch. Safety findings were in line with previous experiences with fentanyl. Both studies showed low variation in fentanyl exposure and delivery via the test patch. The test patch provided equivalent fentanyl exposure at a lower dose than the reference patch formulation with lower variability and the potential to lower medicinal waste.
Corporate Governance Configurations and Corporate Social Responsibility Disclosure: Qualitative Comparative Analysis of Audit Committee and Board characteristics
Authors: Dwekat Aladdin , Seguí‐Mas Elies , Tormo‐Carbó Guillermina , Carmona Pedro 
Published: August 2020

AbstractDrawing on the complexity theory and responding to the recent calls to use such creative methods that mix between a quantitative and qualitative approach. Therefore, this study fills the literature gap, adding novelties, showing evidence from the unexplored (or underexplored) European context and, consequently, shedding light to inconclusive results in previous research concerning the effect of audit committee (AC) and board characteristics on corporate social responsibility (CSR) disclosure by applying a novel research methodology: the fuzzy set qualitative comparative analysis. The data were collected from Eikon database for a sample of the top 69 non‐financial European companies (based on market capitalisation) for the period 2016–2018. The study results support the equifinality and complexity tenets of complexity theory. It also suggests that CSR disclosure relies on a complex configuration of some AC attributes, for example, independence, financial expert member, chair independence, size and activity, and other board characteristics (independence, gender, size, activity, and Chief Executive Officer (CEO) duality). These characteristics play a leading part as a recipe ingredient and, in an appropriate combination, promote achieving high CSR disclosure levels. Our empirical results offer multidimensional and valuable insights for professionals, regulators, and policymakers in establishing and revising the guidelines regarding the AC and board of directors' composition.
The continuing role of breast fine‐needle aspiration biopsy after the introduction of the IAC Yokohama System For Reporting Breast Fine Needle Aspiration Biopsy Cytopathology
Authors: De Rosa Filippo , Migliatico Ilaria , Vigliar Elena , Salatiello Maria , Pisapia Pasquale , Iaccarino Antonino , Russo Daniela , Insabato Luigi , Accurso Antonello , Arpino Grazia , Palombini Lucio , Troncone Giancarlo , Bellevicine Claudio 
Published: August 2020

AbstractBackgroundUltrasound‐guided fine‐needle aspiration biopsy (FNAB) (US‐guided FNAB) is a rapid and cost‐effective procedure for the diagnosis of breast lesions. Our Institution has a long tradition in breast FNAB performed by cytopathologists; recently we adopted both US guidance and a five‐tiered classification system similar to that proposed by the International Academy of Cytology (IAC). The aim of this study was to demonstrate the continuing role of US‐guided FNAB in the diagnosis of breast lesions, despite the growing adoption of core‐needle biopsy (CNB).MethodsThe laboratory information database system was searched to obtain the breast FNAB diagnostic reports recorded from 2010 to 2017 and classified using a five‐tiered Classification System; each entry was matched with the available histology.ResultsA total of 4624 breast FNAB samples were retrieved. Of these, 1745/4624 cases (37.7%) had histological follow‐ups. The risk of malignancy (ROM) was 4.9% for benign, 20.7% for atypical, 78.7% for suspicious of malignancy, and 98.8% for malignant. When the atypical category was evaluated as a negative index, the positive predictive value was 93.73%, and the negative predictive value was 90.78%, reaching an overall diagnostic accuracy of 92.82%.ConclusionsThe IAC Yokohama System for Reporting Breast FNAB Cytopathology clearly identifies different diagnostic categories with increasing ROM. Most of the FNAB samples were classified as benign or malignant (65.3%), warranting prompt management for these patients. Moreover, the inclusion of the atypical category as a low‐risk indeterminate category avoided overtreatment of benign lesions. Thus, despite the well‐established merits of CNB, US‐guided FNAB still represents a cost‐effective and rapid nonoperative diagnostic approach.
Fine needle aspiration of an intrathyroidal parathyroid carcinoma mimicking a primary thyroid anaplastic carcinoma: A case report with review of the literature
Authors: Mir Fatima , Rohra Prih , Aakash Nfn , Furlan Karina , Ghai Ritu , Reddy Vijaya , Cheng Lin , Gattuso Paolo 
Published: August 2020

AbstractIntrathyroidal parathyroid carcinoma is an uncommon malignancy. A 46‐year‐old male presented with a left neck mass. Computed tomography (CT) scan revealed a hypodense mass in the left thyroid lobe along with evidence of metastatic lymphadenopathy. Aspiration of the left thyroid nodule was performed, and a diagnosis of malignancy was rendered, favoring a primary anaplastic carcinoma. Based on the cytologic diagnosis, the patient underwent a total thyroidectomy. Before the surgery, intact parathyroid hormone (PTH) and calcium level (PTH = 78 pg/mL; Calcium = 10.6 mg/dL) were found to be minimally elevated. On gross examination, a 3.2 cm mass within the left inferior thyroid lobe was seen. Histopathologic examination and ancillary studies supported the diagnosis of a parathyroid carcinoma. We, hereby present, an exceedingly rare presentation of an intrathyroidal parathyroid carcinoma with only minimal elevation of PTH and calcium, mimicking a primary anaplastic thyroid carcinoma on cytologic examination.
The bioenergetics of neuronal morphogenesis and regeneration: Frontiers beyond the mitochondrion
Authors: Gallo Gianluca 
Published: August 2020

AbstractThe formation of axons and dendrites during development, and their regeneration following injury, are energy intensive processes. The underlying assembly and dynamics of the cytoskeleton, axonal transport mechanisms, and extensive signaling networks all rely on ATP and GTP consumption. Cellular ATP is generated through oxidative phosphorylation (OxP) in mitochondria, glycolysis and “regenerative” kinase systems. Recent investigations have focused on the role of the mitochondrion in axonal development and regeneration emphasizing the importance of this organelle and OxP in axon development and regeneration. In contrast, the understanding of alternative sources of ATP in neuronal morphogenesis and regeneration remains largely unexplored. This review focuses on the current state of the field of neuronal bioenergetics underlying morphogenesis and regeneration and considers the literature on the bioenergetics of non‐neuronal cell motility to emphasize the potential contributions of non‐mitochondrial energy sources.
Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators
Authors: Leaney Amy E. , Beck Paul , Biddle Simon , Brown Paul , Grace Philip B. , Hudson Simon C. , Mawson Deborah H. 
Published: August 2020

AbstractSelective androgen receptor modulators (SARMs) are compounds with specific androgenic properties investigated for the treatment of conditions such as muscle wasting diseases. The reported androgenic properties have resulted in their use by athletes, and consequently they have been on the World Anti‐Doping Agency prohibited list for more than a decade. SARMs have been investigated by pharmaceutical companies as potential drug candidates, but to date no SARM has demonstrated sufficient safety and efficacy to gain clinical approval by either the European Medicines Agency or the U.S. Food and Drug Administration. Despite their lack of safety approval, SARMs are often illegally marketed as dietary supplements, available for consumers to buy online. In this study, a range of supplement products marketed as SARMs were purchased and analyzed using high resolution accurate mass – mass spectrometry to evaluate the accuracy of product claims and content labeling. This study found discrepancies ranging from a supplement in which no active ingredients were found, to supplements containing undeclared prohibited analytes. Where SARMs were detected, discrepancies were observed between the concentrations measured and those detailed on the product packaging. The outcome of this experiment highlights the high risk of such supplement products to consumers. The inaccurate product claims give rise to uncertainty over both the dose taken and the identity of any of these unapproved drugs. Even for supplements for which the product labeling is correct, the lack of complete toxicity data, especially for combinations of SARMs taken as stacks, means that the safety of these supplements is unknown.