bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Resynchronization Therapy and Risk of Recurrent Hospitalizations in Patients Without Left Bundle Branch Block
Authors: Vidula Himabindu , Lee Elizabeth , McNitt Scott , Polonsky Bronislava , Aktas Mehmet , Rosero Spencer , Younis Arwa , Solomon Scott D. , Zareba Wojciech , Kutyifa Valentina , Goldenberg Ilan 
Published: July 2020

Background:
Mild heart failure (HF) patients without left bundle branch block (LBBB) did not derive a significant reduction in risk of a HF event/death in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy). However, the efficacy of CRT with a defibrillator (CRT-D) may be modified after the development of the first hospitalization for HF (HHF). We aimed to study the effect of CRT-D on long-term risk of recurrent HHF in patients without LBBB in MADIT-CRT.

Methods:
Data on recurring HHF were collected for 1818 subjects. The CRT-D versus implantable cardioverter-defibrillator-only risk for first and subsequent HHF was assessed by QRS morphology in on-treatment analysis using Cox proportional hazards regression modeling.

Results:

During long-term follow-up, 412 patients had ≥1 HHF and 333 had ≥2 HHF. Multivariate analysis revealed that in LBBB patients, CRT-D, compared with implantable cardioverter-defibrillator, was associated with a significant reduction in risk of first and subsequent HHF (first: hazard ratio, 0.41 [95% CI, 0.31–0.54],
P
<0.001; subsequent: hazard ratio, 0.45 [95% CI, 0.29–0.70],
P
<0.001). Among patients without LBBB, the benefit of CRT-D was nonsignificant for the first HHF (hazard ratio, 0.96;
P
=0.808). However, after occurrence of a first HHF, CRT-D therapy was associated with a pronounced 44% reduction in risk of subsequent HHF (hazard ratio, 0.56 [95% CI, 0.32–0.97],
P
=0.039). Patients without LBBB with ≥1 HHF during the first year of follow-up demonstrated increasing dyssynchrony at 1 year compared with those who had no HHF (
P
=0.016).

Conclusions:
In MADIT-CRT, we show a beneficial effect of CRT-D in patients without LBBB subsequent to development of a first HHF, possibly due to increased dyssynchrony associated with HF progression.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00180271, NCT01294449, and NCT02060110.
The Quaker Renaissance and Liberal Quakerism in Britain, 1895–1930
Authors: Dales Joanna 
Published: July 2020

Abstract
Many Quakers who reached maturity towards the end of the nineteenth century found that their parents’ religion had lost its connection with reality. New discoveries in science and biblical research called for new approaches to Christian faith. Evangelical beliefs dominant among nineteenth-century Quakers were now found wanting, especially those emphasising the supreme authority of the Bible and doctrines of atonement whereby the wrath of God is appeased through the blood of Christ. Liberal Quakers sought a renewed sense of reality in their faith through recovering the vision of the first Quakers with their sense of the Light of God within each person. They also borrowed from mainstream liberal theology new attitudes to God, nature and service to society. The ensuing Quaker Renaissance found its voice at the Manchester Conference of 1895, and the educational initiatives which followed gave to British Quakerism an active faith fit for the testing reality of the twentieth century.
Problematyka konfliktów społecznych w exposés polskich premierów z lat 2007–2017
Authors: Pękala Mateusz 
Published: July 2020

Issues of Social Conflicts in Inauguration Speeches of Polish Prime Ministers in 2007–2017The article presents the assumptions and results of an analysis of the content of inauguration speeches of Polish Prime Ministers in 2007–2017: Donald Tusk (2007 and 2011), Ewa Kopacz (2014), Beata Szydło (2015) and Mateusz Morawiecki (2017). The aim of the study has been to answer the question whether and to what extent the issues of social conflicts were present in the speeches and what dispute resolution strategies were announced by the government. Social tensions were one of the leitmotifs of each of those speeches, mainly in the context of their negative impact on the effectiveness of public policy. The speeches often called for a reduction in rivalry both between political actors and between social groups. The need to overcome the crisis of citizens’ trust in state institutions was also ascribed great importance. In the face of social conflicts, the prime ministers announced that they would play the role of an “arbiter”, who would decide how particular resources would be distributed (more often), or a “negotiator”, who would conduct a partner dialogue with other social actors in order to reach a common agreement (less often). Problematyka konfliktów społecznych w exposés polskich premierów z lat 2007–2017Artykuł przedstawia założenia oraz wyniki analizy treści exposés polskich Prezesów Rady Ministrów z lat 2007–2017: Donalda Tuska (2007 i 2011), Ewy Kopacz (2014), Beaty Szydło (2015) i Mateusza Morawieckiego (2017), która służyła odpowiedzi na pytanie: czy i w jakim zakresie w wystąpieniach obecna była problematyka konfliktów społecznych oraz jakie strategie rozwiązywania sporów przez rząd były zapowiadane. Napięcia społeczne były jednym z motywów przewodnich każdego exposé, głównie w kontekście ich negatywnych skutków dla skuteczności polityki publicznej. W przemówieniach często pojawiały się apele o ograniczenie rywalizacji zarówno pomiędzy siłami politycznymi, jak i pomiędzy grupami społecznymi. Duże znaczenie przypisywano także konieczności przełamania kryzysu zaufania obywateli od instytucji państwowych. Wobec konfliktów społecznych premierzy zapowiadali pełnienie roli „arbitra” władczo rozstrzygającego, w jaki sposób przeprowadzona zostanie dystrybucja określonych zasobów (częściej), lub „negocjatora” prowadzącego partnerski dialog z innymi podmiotami społecznymi w celu wypracowania wspólnego porozumienia (rzadziej).
Management of Esophageal Lung in a Patient With VACTERL Anomalies
Authors: Harrell Kevin N. , Brent Moss Jonathan , Dave Bhattacharya Syamal , Koontz Curtis S. 
Published: July 2020

Esophageal lung is a rare type of bronchopulmonary foregut malformation where an anomalous main bronchus arises from the esophagus rather than the trachea. This differentiates from an esophageal bronchus where a lobar bronchus arises from the esophagus. Fewer than 30 of these anomalies have been reported in the literature. A female infant was born at 35 weeks gestational age and found to have multiple congenital abnormalities including cleft palate, long-gap esophageal atresia, tracheoesophageal fistula (TEF), imperforate anus, and renal anomalies. She initially underwent thoracoscopic ligation of TEF with colostomy and mucus fistula creation. Bronchoscopy found no right mainstem bronchus, and subsequent computed tomography scan was consistent with possible esophageal bronchus. Esophagoscopy through the gastrostomy discovered a fistulous connection between the distal esophagus and anomalous main right bronchus. Right thoracotomy with pneumonectomy of the hypoplastic lung was performed. She subsequently underwent vaginostomy for hydrometrocolpos. Her proximal esophagus was diverted with a cervical esophagostomy for control of secretions. She also required tracheotomy and is currently at home on minimal ventilator settings awaiting staged reconstruction. Esophageal lung is a rare congenital abnormality with few reported cases. Surgical treatment with pneumonectomy is often required, and pediatric surgeons should be familiar with these congenital bronchopulmonary malformations.
Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Authors: Sharbel Daniel D. , Abkemeier Mary , Groves Michael W. , Albergotti William G. , Byrd J. Kenneth , Reyes-Gelves Camilo 
Published: July 2020

Objective: The incidence of occult metastasis (OM) in laryngeal squamous cell carcinoma (SCC) is still widely debated. In this systematic review, we aim to determine the rate of OM in laryngeal SCC, its impact on recurrence, and the role of elective neck dissection (END) in the management of the clinically negative neck. Methods: A systematic review of the English-language literature in Web of Science, PubMed, MEDLINE, and Cochrane Library databases on occult metastasis in laryngeal SCC from 1977 to 2018 was conducted. Studies evaluating occult metastasis (OM) in patients with laryngeal SCC with clinically negative necks undergoing surgery were included. Studies evaluating other head and neck subsites, clinically node positive, and salvage patients were excluded. Results: Twenty-one articles with a total of 5630 patients were included. The overall rate of OM was 20.5% and was 23% and 12.2% in supraglottic and glottic tumors, respectively. The OM rate in T1-T2 tumors was 13% and 25% in T3-T4 tumors. T3-T4 tumors had significantly greater odds of developing OM compared to T1-T2 tumors (Odds Ratio [OR] = 2.61, 95% Confidence Interval [CI] = 1.92-3.55, P < .00001). Patients with OM were more likely to develop distant metastasis (OR = 5.65, 95% CI = 3.36-9.51, P < .00001). Conclusions: Patients with advanced T-stage laryngeal SCC should undergo elective neck treatment. More aggressive treatment for patients with history of OM should be considered due to the risk of subsequent regional and distant metastasis. Level of Evidence: II
Feasibility of Free Flap Reconstruction Following Salvage Robotic-Assisted Resection of Recurrent and Residual Oropharyngeal Cancer in 3 Patients
Authors: Williamson Andrew , Haywood Matthew , Awad Zaid 
Published: July 2020

Introduction: Human papilloma virus (HPV)–positive oropharyngeal cancer carries a good prognosis when managed with primary chemoradiotherapy. However, the dramatically increasing rate of this disease means more patients are now developing recurrence, with surgery remaining the mainstay of treatment. Despite this, there is no agreed technique for excision of recurrent oropharyngeal cancer. Objective: We describe the transoral robotic technique employed by our head and neck multidisciplinary team (MDT) in the management of patients with recurrent HPV positive oropharyngeal cancer and assess their symptom severity using quality of life and swallowing questionnaires. Method: Three (2 males:1 female, mean age 60.7 years) patients with recurrent or residual p16 positive oropharyngeal cancer following radical chemoradiotherapy were identified. All patients underwent selective neck dissection, tracheostomy, and transoral robotic surgery (TORS)–assisted partial oropharyngeal resection with the resultant defect closed with a robotic assisted radial forearm free flap (RFFF). Patient quality of life, symptom severity, and swallowing were assessed pre- and postoperatively using the University of Washington Quality of Life score and MD Anderson Dysphagia Index (MDADI). Results: Histopathological examination revealed complete clearance of the primary lesion in all cases. Two patients made uneventful recoveries, while one patient developed a chest infection and tracheocutaneous fistula managed conservatively. Mean inpatient stay was 15 days (range 8-27). University of Washington Quality of Life and MDADI scores showed a mild improvement in symptoms following surgery. Conclusion: Surgical management of recurrent oropharyngeal cancer remains a technical challenge; however, MDT discussion and judicious use of TORS oropharyngeal resection and RFFF can result in good oncological and quality of life outcomes with acceptable postoperative complications and symptoms.
Cerebral schistosomiasis: MRI features with pathological correlation
Authors: Lu Chun-yan , Zhao Sha , Wei Yi 
Published: July 2020

Background Neuroschistosomiasis is not commonly encountered and is probably underrecognized. We hope these findings can help clinicians and radiologists to raise awareness of this disabling disorder. Purpose To demonstrate the magnetic resonance imaging (MRI) findings of cerebral schistosomiasis and correlate it with pathological findings. Material and Methods We identified seven patients with cerebral schistosomiasis from radiology and pathology archives of our hospital. Of the seven patients, six were pathologically confirmed. The remaining patient had pathologically confirmed spinal schistosomiasis with MRI findings of cerebral involvement. MRI and pathological findings of these patients were analyzed and correlated. Results Multiple enhancing nodules at varying size were found in all patients. Prominent leptomeningeal or choroidal veins were found in six patients, four at the center of the foci and two at the periphery. Hemorrhage was identified in two patients. Histology revealed granulomas around ova in six patients. A prominent vein with ova in the lumen and wall of a vein was found in one patient and perivascular ova deposition was found in one patient. Conclusion Multiple enhancing nodules with central or peripheral veins in a circumscribed brain area are important signs to the diagnosis of cerebral schistosomiasis. The inflamed veins involved may be the route taken by the ova to spread to the brain tissue.
The Southern California Lupus Registry: I. Baseline characteristics of lupus patients in uncharted territory
Authors: Sandhu Vaneet K , Teh Phildrich , Zakhary Bishoy , Liu Joshua 
Published: July 2020

Objective This study aimed to determine the baseline characteristics of a multi-ethnic systemic lupus erythematosus (SLE) cohort in Southern California established with the intent of addressing regional health inequity. Methods Patients ≥18 years of age with SLE per the Systemic Lupus International Collaborating Clinics (SLICC) criteria were recruited into the Southern California Lupus Registry (SCOLR) if they resided in San Bernardino and Riverside counties in California. Individuals were categorized according to their stated ethnicity as non-Hispanic White, Hispanic, Black, or Asian. Descriptive statistics were utilized for analysis. Predictors of renal disease were assessed by binomial regression. Results The SCOLR cohort comprised 162 patients: 57 non-Hispanic White, 58 Hispanic, 17 Asian, and 30 Black. A difference in the rate of renal involvement and SLE duration was found among the four ethnic groups. Renal involvement was significantly higher in Hispanics compared with non-Hispanic Whites. Conclusion In line with other cohorts, this study shows greater renal involvement in Hispanics than non-Hispanic Whites, demonstrating a need for more aggressive screening and early intervention to improve long-term outcomes. As a multi-ethnic SLE cohort, the SCOLR serves as a foundation for longitudinal studies addressing health inequity in this region.
Practice, clinician, and patient factors associated with the adoption of lung cancer screening
Authors: Hochheimer Camille J , Sabo Roy T , Tong Sebastian T , Westfall Matthew , Wolver Susan E , Carney Stacie , Day Teresa , Krist Alex H 
Published: July 2020

Objectives Lung cancer remains the leading cause of cancer-related deaths in the United States. In 2013, the US Preventive Services Task Force recommended annual screening for lung cancer with low-dose computed tomography in adults meeting certain criteria. This study seeks to assess lung cancer screening uptake in three health systems. Setting This study was part of a randomized controlled trial to engage underserved populations in preventive care and includes 45 primary care practices in eight states. Methods Practice and clinician characteristics were manually collected. Lung cancer was measured from electronic health record data. A generalized linear mixed model was used to assess characteristics associated with screening. Results Patient records between 2012 and 2016 were examined. Lung cancer screening uptake overall increased only slightly after the guideline change (2.8–5.6%, p < 0.01). One health system did not show an increase in uptake (0.2–0.1%, p = 0.32), another had a clinically insignificant increase (1.5–2.9%, p < 0.01), and the third nearly doubled its higher baseline screening rate (10.4–19.1%, p < 0.01). Within the third health system, patients more likely to be screened were older, male, had more comorbid conditions, visited the office more frequently, were seen in practices closer to the screening clinic, or were uninsured or covered by Medicare or Medicaid. Conclusions Certain patients appeared more likely to be screened. The only health system with increased lung cancer screening explicitly promoted screening rather than relying on clinicians to implement the new guideline. Systems approaches may help increase the low uptake of lung cancer screening.
Newly graduated nurses’ experiences of horizontal violence
Authors: Rosi Ivana Maria , Contiguglia Adriana , Millama Kim Randall , Rancati Stefania 
Published: July 2020

Background: Horizontal violence, defined in the literature as ‘interpersonal conflict between two nurses at the same hierarchical levels in organizations’, often associated with bullying, affects the well-being of nurses, care recipients and the professional image of nursing and the organization due to increased turnover. One in every three newly graduated nurses is a victim of horizontal violence, although they do not always know how to define it. Aim: To investigate the direct and indirect experiences of horizontal violence in newly graduated nurses as well as to shed light on the phenomenon, on its awareness and recognition. Methods: A qualitative phenomenological study was conducted between September and October 2018 with newly graduated nurses, with a work experience ranging between 6 months and 3 years. The interviews were conducted face-to-face, consisting of a first open general question, followed by semi-structured questions. Ethical considerations: The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Institution Review Board. Results: From the analysis of the interviews of the 21 participants, four main themes were identified: the ‘enemies’, that is those who exercised violence, the ‘weapons’ used by them to exercise violence, the ‘effects’ and the types of ‘armor’ identified to protect themselves. Discussion: Horizontal violence is rarely recognized by newly graduated nurses, even though our sample had directly or indirectly experienced horizontal violence. Tackling the phenomenon starting from the undergraduate degree courses, focusing on effective support and more protection by the organization leaders were the silent requests that emerged from this study. Conclusion: Preventing horizontal violence is important for nurses’ professional and private well-being, for professional conduct and for the quality of care provided to patients.
Characterization of relapse patterns in patients with acute lymphoblastic leukemia treated with blinatumomab
Authors: Lau Kimberly M , Saunders Ila M , Goodman Aaron M 
Published: July 2020

Introduction Blinatumomab is a CD19/CD3 bispecific T-cell engager (BiTE) antibody that simultaneously binds CD19 on the surface of B-cells and CD3 on the surface of T-cells, resulting in tumor cell lysis. It is approved for the treatment of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and in patients with minimal residual disease after intensive induction chemotherapy. Relapse patterns after treatment with blinatumomab have not been well characterized. Methods We reviewed patients treated with blinatumomab with relapsed, refractory or minimal residual disease-positive B-ALL from 1 December 2014 to 31 December 2018 at a single academic medical center. Patient demographics, blast percentage prior to blinatumomab initiation, prior lines of therapy, blinatumomab treatment duration, sites of relapse, progression free survival, and overall survival were collected. Results A total of 20 patients were identified. Four (20%) patients developed extramedullary relapse following blinatumomab. The median time from treatment initiation to extramedullary relapse was 179 days (range 47–241). Sites of extramedullary relapse included the pancreas, adrenal gland, kidneys, liver, parotid gland, and brain. Conclusion Extramedullary relapse occurs frequently following treatment of B-ALL with blinatumomab. Further studies aimed at preventing extramedullary relapse following blinatumomab treatment are warranted.
Physical and chemical stability of cytarabine in polypropylene syringes
Authors: Ayed Wiem Ben , Drira Chema , Soussi Mohamed Ali , Ouesleti Hanen , Hamdene Besma , Khrouf Myriam , Safta Fathi , Fradi Ines 
Published: July 2020

Background Cytarabine is widely used to treat leukemia and lymphoma. Currently, Cyrabol®, powder for injection, is one of the specialties marketed in Tunisia. However, no stability data when diluted with 0.9% NaCl are available. The aim of this study is to evaluate the physical and chemical stability of cytarabine (Cyrabol®) solution after dilution in 0.9% NaCl (1 mg/mL, 5 mg/mL and 10 mg/mL) in polypropylene syringes under different storage conditions. Methods Cytarabine solutions (1 mg/mL, 5 mg/mL and 10 mg/mL) in 0.9% NaCl were prepared in polypropylene syringes and stored for 28 days under different conditions. Cytarabine preparations in glass containers were prepared as a control to detect any adsorption. Chemical stability was assessed by a stability-indicating high-performance liquid chromatography method. The stability-indicating capacity of the method was proved by forced degradation tests. Linearity, precision and limit of detection and quantification were performed according to the International Conference on Harmonisation recommendations. Physical stability was checked by visual inspection. Results The method was proven to be a validated stability-indicating assay. At 2–8°C, all tested solutions were chemically stable for 28 days. However, at 25°C, the main degradation product gradually increased during the study and the chemical stability of 1 mg/mL, 5 mg/mL and 10 mg/mL solutions was 14 days, 8 days and 5 days, respectively. Similar results were observed in the glass containers. Conclusion The highest physical and chemical stability of cytarabine diluted in 0.9% NaCl in polypropylene syringes was observed at 2–8°C. At 25°C, better stability was found in the 1 mg/mL solution compared with those at higher concentrations (5 mg/mL and 10 mg/mL).