bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Priority Supply Chain Distribution Using DEMATEL Method in Instant Noodle Company
Authors: Siregar I , Saedon J.B. , Mohd Shahriman Adenan 
Published: October 2019

Abstract
The company has a supply chain aims to improve company performance. The supply chain has a distribution center matches the company goals. Companies produce instant noodles have many branches spread in various regions. In order to achieve this goal, the company must determine the priority of the distribution center in the supply chain and analyze the relationship between each factor affects the distribution center to increase the flow of materials and information and the productivity of the company increase. Determination of company supply chain distribution priorities is done by using the DEMATEL method in knowing the criteria influences the selection of supply chain distribution centers. The criteria used are the four Balance Scorecard criteria, namely Financial, Internal, Customer and Learning & Growth. Then distributing priorities are obtained and the relationship of influence between criteria and distribution center. Based on the analysis of the distribution center in the company (Jambi, Medan, Aceh, Riau and Padang), it is obtained that the weighting value for prioritizing the distribution in sequence is 1,0035; 1,5649; 1,3789; 1,2605 and 1,2688. Then it is find out the level of importance sequentially, namely Medan, Aceh, Padang, Riau and Jambi.
Study of SMS gateway service application at the one stop agency of Medan city investment and service for licensing customer satisfaction
Authors: Nasution M A , Regif S Y 
Published: October 2019

Abstract
This research is about the Index of Public Satisfaction on the management of public services that are managed specifically for its users through the application of a service information system called the SMS Gateway. This application system provides information on licensing services in the Medan City of One Stop Agency Service and Investment Service in fulfilling requests from licensing service users without having to come to the DPMPTSP Medan office to get information on the progress of permits that have been entered in the licensing application. This research has an important objective, namely to provide a measurable analysis of the ability of state civil apparatus to manage access to be information technology progress for the benefit of the community, especially users of SMS Gateway, which is based on the assessment of community satisfaction and demands for the development of the industrial era 4.0. Based on information received from the DPMPTSP in Medan City, which was every day at the customer hall serves no less than 40 people who need licensing services within the workday span of 3 months, Monday - Friday totalling 40 x 60 days = 2400 populations with the number of samples 331 people.
Implementation of Porter Stemmer Algorithm to Obtain Basic Words in Toba Batak Language Documents with the Two-Level Morphological Method
Authors: Muchtar M A , Nababan Erna B , Nababan Manguji , Andayani U , Simanjuntak Tuti , Sitompul Opim S 
Published: October 2019

Abstract
Stemming is the process of deciphering words by carrying out affixes to words to get the right base words. In its development stemming has been developed for various languages, including Porter Stemmer. In this study, the stem was used to add Toba Batak language. Decapitation of affixes in the Toba Batak language is difficult because there are essential words that contain affixes and there are essential words that decay when affixed, namely the essential words beginning with the letter’s ‘t’, ‘s’ and ‘p’. To solve this problem by offering the implementation of a porter stemmer algorithm using the two-level morphological method. This stemmer method uses a dictionary of essential words. Each step in the stemmer process will always check the lexicon of the essential words so that the essential words that contain affixes will not be monitored, and if the word is not in the dictionary the basic word will not be stemming so when there are a name people or place names that contain affixes will not be implemented. The use of two levels of morphology was applied to the essential words beginning with the letter’s ‘t’, ‘s’ and ‘p’ to get the right essential words. From the results of testing on 20 Toba Batak language documents, the Porter stemmer algorithm with two levels of morphology can produce an accuracy rate of 87.503% with an average speed of 0.000460798 seconds per word.
Effect of internal heat exchanger to the performance of vapor compression cycle using refrigerant R32
Authors: Sihombing H V , Nasution A H , Ambarita H 
Published: October 2019

Abstract
Vapor compression refrigeration cycle generally is used in the Air-Conditioning (AC) system. In order to increase the energy efficiency, the Coefficient of Performance (COP) of the cycle need to be enhanced. Many innovations can be used, one is to utilize internal heat exchanger (IHX). In this work, the effect of IHX in the vapor compression cycle with refrigerant R32 is investigated and compared with refrigerant R22. The analyses are carried out at temperature evaporation of -5°C, 0°C, and 5°C by using software ASPEN PLUS. The results show that effect of IHX in the cycle with refrigerant R22 increases the COP from 22.78% to 25.61%. On the other hand, in the cycle with refrigerant R32 the COP increases from 33.79% to 36.80%. The average increase for the cycle with refrigerant R22 and refrigerant R32 is 24.14% and 37.04%, respectively. This fact reveals that IHX in the cycle with R32 is more effective that the cycle with refrigerant R22.
Modeling of Multilayer MMIC Coplanar Waveguide Low Pass Filter for Cellular Application
Authors: Sedayu Cakra D. , Sinulingga Emerson P. , Hasan Syafruddin 
Published: October 2019

Abstract
In the early development of Monolithic Microwave Integrated Circuit (MMIC) technology, most of the components use Microstrip structure. In order to connect the active components to the ground in the Microstrip design is limited by the thickness of the substrate to avoid circuit performance degradation due to vertical coupling. Thus it can be said that the Microstrip is not the primary choice of design in operating components at microwave and millimeter wave frequencies. The Coplanar Waveguide (CPW) design technique was proposed as an alternative to the Microstrip structure for MMIC components. With CPW design technique, it generates components and circuits which are cost-effective and allow miniaturization of components in MMIC environment. In this paper, CPW Low Pass Filter (LPF) electromagnetic modeling has been demonstrated based on multilayer MMIC technology for the 2,100 MHz mobile application. The LPF CPW specification has been modeled with the substrate of GaAS (εr=12.9) and Polymide (ϵr=3.7). The thickness of GaAS substrate and Polyimide dielectric is 600 micron and 2.5 micron respectively for each layer.
Development of unsteady multi-hole pressure probes based on fiber-optic pressure sensors
Authors: Heckmeier Florian M , Iglesias Daniel , Kreft Stefanie , Kienitz Sascha , Breitsamter Christian 
Published: October 2019

Abstract
For measurements of unsteady flow phenomena with multi-hole pressure probes, pressure transducers are integrated in the probe near the probe tip. The application of additive manufacturing enables a wide variation in probe geometries for complex use cases. The spatial characteristics of the unsteady probe are determined by the steady state calibration in a known free-jet wind tunnel. Furthermore, the acoustic/pneumatic line-cavity system, that emerges inside the channels of the probe, is investigated in detail in the temporal calibration. In order to realize multi-hole probes with higher temporal resolution, which can be operated in harsh environments, a fiber-optic pressure sensor is developed. The measurement principle of the fiber-optic sensor is based on the Fabry-Pérot interferometer effect. The sensor is operated differentially with a pressure capillary by either pressurizing the sensor or using the surrounding static pressure as the reference pressure. Besides calibration of the sensor, comparisons with a state-of-the-art piezo-resistive pressure transducer have been performed. The focus of this work is on the reproducibility of both frequency response and amplitude.
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma
Authors: Schulz D , Streller M , Piendl G , Brockhoff G , Reichert T E , Menevse A N , Beckhove P , Hautmann M G , Bauer R J , Ettl T 
Published: October 2019

AbstractImmunotherapy by blockade of the PD-1/PD-L1 checkpoint demonstrated amazing tumor response in advanced cancer patients including head and neck squamous cell carcinoma (HNSCC). However, the majority of HNSCC patients still show little improvement or even hyperprogression. Irradiation is currently investigated as synergistic treatment modality to immunotherapy as it increases the number of T-cells thereby enhancing efficacy of immunotherapy. Apart from this immunogenic context a growing amount of data indicates that PD-L1 also plays an intrinsic role in cancer cells by regulating different cellular functions like cell proliferation or migration. Here, we demonstrate opposing membrane localization of PD-L1 in vital and apoptotic cell populations of radioresistant (RR) and radiosensitive (RS) HNSCC cell lines up to 72 h after irradiation using flow cytometry. Moreover, strong PD-L1 expression was found in nuclear and cytoplasmic cell fractions of RR. After irradiation PD-L1 decreased in nuclear fractions and increased in cytoplasmic fractions of RR cells. In contrast, RS cell lines did not express PD-L1, neither in the nucleus nor in cytoplasmic fractions. Additionally, overexpression of PD-L1 in RS cells led to a proportional increase of vital PD-L1 positive cells after irradiation. Moreover, co-immunoprecipitation experiments revealed an interaction between Akt-1 and PD-L1, mostly in irradiated RR cells compared to RS cells suggesting a differential influence of PD-L1 on cell signaling. In summary, our data imply the need for different therapeutic strategies dependent on the molecular context in which PD-L1 is embedded.
Connecting signals and benefits through partner choice in plant–microbe interactions
Authors: Younginger Brett S , Friesen Maren L 
Published: October 2019

ABSTRACT
Stabilizing mechanisms in plant–microbe symbioses are critical to maintaining beneficial functions, with two main classes: host sanctions and partner choice. Sanctions are currently presumed to be more effective and widespread, based on the idea that microbes rapidly evolve cheating while retaining signals matching cooperative strains. However, hosts that effectively discriminate among a pool of compatible symbionts would gain a significant fitness advantage. Using the well-characterized legume–rhizobium symbiosis as a model, we evaluate the evidence for partner choice in the context of the growing field of genomics. Empirical studies that rely upon bacteria varying only in nitrogen-fixation ability ignore host–symbiont signaling and frequently conclude that partner choice is not a robust stabilizing mechanism. Here, we argue that partner choice is an overlooked mechanism of mutualism stability and emphasize that plants need not use the microbial services provided a priori to discriminate among suitable partners. Additionally, we present a model that shows that partner choice signaling increases symbiont and host fitness in the absence of sanctions. Finally, we call for a renewed focus on elucidating the signaling mechanisms that are critical to partner choice while further aiming to understand their evolutionary dynamics in nature.
Protein aggregation in bacteria
Authors: Schramm Frederic D , Schroeder Kristen , Jonas Kristina 
Published: October 2019

ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence. Numerous past studies, mostly performed in Escherichia coli, have led to a detailed understanding of the functions of the bacterial protein quality control machinery in preventing and reversing protein aggregation. However, more recent research points toward unexpected diversity in how phylogenetically different bacteria utilize components of this machinery to cope with protein aggregation. Furthermore, how persistent protein aggregates localize and are passed on to progeny during cell division and how their presence impacts reproduction and the fitness of bacterial populations remains a controversial field of research. Finally, although protein aggregation is generally seen as a symptom of stress, recent work suggests that aggregation of specific proteins under certain conditions can regulate gene expression and cellular resource allocation. This review discusses recent advances in understanding the consequences of protein aggregation and how this process is dealt with in bacteria, with focus on highlighting the differences and similarities observed between phylogenetically different groups of bacteria.
Unique Phenotypic Characteristics and Clinical Course in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Multicenter US Experience
Authors: Wang Ming-Hsi , Mousa Omar Y , Friton Jessica J , Raffals Laura E , Leighton Jonathan A , Pasha Shabana F , Picco Michael F , Cushing Kelly C , Monroe Kelly , Nix Billy D , Newberry Rodney D , Faubion William A 
Published: October 2019

AbstractIntroductionUlcerative colitis (UC) associated with primary sclerosing cholangitis (PSC) is a rare phenotype. We aimed to assess patients with UC-PSC or UC alone and describe differences in clinical and phenotypic characteristics, antitumor necrosis factor (TNF) therapy, and long-term clinical outcomes.MethodsThis retrospective multicenter cohort study included patients who received a diagnosis of UC from 1962 through 2015. We evaluated clinical factors associated with UC-PSC vs UC alone and assessed associations by using multivariable logistic regression models.ResultsAmong 522 patients with UC, 56 (10.7%) had PSC. Compared with UC alone, patients with UC-PSC were younger (younger than 20 years) at diagnosis (odds ratios [OR], 2.35; adjusted P = 0.02) and had milder UC severity (adjusted P = 0.05), despite having pancolonic involvement (OR, 7.01; adjusted P &lt; 0.001). In the biologics era (calendar year 2005 to 2015), patients with UC-PSC less commonly received anti-TNF therapy compared with patients with UC (OR, 0.38; adjusted P = 0.009), but their response rates were similar. Fewer patients with UC-PSC received corticosteroids (OR, 0.24; adjusted P = 0.005) or rectal 5-aminosalicyte acid (OR, 0.26; adjusted P &lt; 0.001). Other differences were identified that were not statistically significant in a multivariable model: patients with UC-PSC more commonly were male, had lower rates of smoking, and had higher rates of colorectal cancer and colectomy.DiscussionThis study identified a unique phenotype of UC with concurrent PSC, which had different clinical behavior compared with UC only. These phenotypic characteristics can help identify high-risk patients with UC before PSC is diagnosed and guide different management and monitoring strategies.
Justifying the culture of justification
Authors: Möller Kai 
Published: October 2019

Abstract
The ideas of the culture of justification—according to which it is the role of the courts to ensure that every act of the state that affects a person is substantively justifiable—and the related right to justification—which claims that every person possesses a moral and, ideally, constitutional right to the justification that the culture of justification recommends—are intuitively powerful and widely discussed ideas in public law scholarship, but their moral foundation is not yet well understood. This article presents the moral case for these two concepts, which centers on the status of every person as a justificatory agent. It argues that under conditions of reasonable disagreement in politics, this status requires that any law or act be justified not only procedurally (e.g. in terms of a democratic vote) but also substantively, and it further demonstrates the necessity of the judicial protection of the right to justification as a matter of principle.
CHIRRUP: a practical algorithm for unsourced multiple access
Authors: Calderbank Robert , Thompson Andrew 
Published: October 2019

Abstract
Unsourced multiple access abstracts grantless simultaneous communication of a large number of devices (messages) each of which transmits (is transmitted) infrequently. It provides a model for machine-to-machine communication in the Internet of Things, including the special case of radio-frequency identification, as well as neighbour discovery in ad hoc wireless networks. This paper presents a fast algorithm for unsourced multiple access that scales to ${\mathscr{C}}=2^{100}$ (active or non-active) devices (arbitrary $100$ bit messages). The primary building block is multiuser detection of binary chirps, which are simply codewords in the second-order Reed–Muller code. The chirp detection algorithm originally presented by Howard et al. (2008, 42nd Annual Conference on Information Sciences and Systems) is enhanced and integrated into a peeling decoder designed for a patching and slotting framework. In terms of both energy per bit and number of active devices (number of transmitted messages), the proposed algorithm is within a factor of $2$ of state-of-the-art approaches. A significant advantage of our algorithm is its computational efficiency. We prove that the worst-case complexity of the basic chirp reconstruction algorithm is ${\mathscr{O}}[nK(\log _2^2 n + K)]$, where $n$ is the codeword length and $K$ is the number of active users. Crucially, the complexity is sublinear in ${\mathscr{C}}$, which makes the reconstruction computationally feasible—a claim we support by reporting computing times for our algorithm. Our performance and computing time results represent a benchmark against which other practical algorithms can be measured.
Protecting patient privacy in survival analyses
Authors: Bonomi Luca , Jiang Xiaoqian , Ohno-Machado Lucila 
Published: October 2019

AbstractObjectiveSurvival analysis is the cornerstone of many healthcare applications in which the “survival” probability (eg, time free from a certain disease, time to death) of a group of patients is computed to guide clinical decisions. It is widely used in biomedical research and healthcare applications. However, frequent sharing of exact survival curves may reveal information about the individual patients, as an adversary may infer the presence of a person of interest as a participant of a study or of a particular group. Therefore, it is imperative to develop methods to protect patient privacy in survival analysis.Materials and MethodsWe develop a framework based on the formal model of differential privacy, which provides provable privacy protection against a knowledgeable adversary. We show the performance of privacy-protecting solutions for the widely used Kaplan-Meier nonparametric survival model.ResultsWe empirically evaluated the usefulness of our privacy-protecting framework and the reduced privacy risk for a popular epidemiology dataset and a synthetic dataset. Results show that our methods significantly reduce the privacy risk when compared with their nonprivate counterparts, while retaining the utility of the survival curves.DiscussionThe proposed framework demonstrates the feasibility of conducting privacy-protecting survival analyses. We discuss future research directions to further enhance the usefulness of our proposed solutions in biomedical research applications.ConclusionThe results suggest that our proposed privacy-protection methods provide strong privacy protections while preserving the usefulness of survival analyses.
Efficacy of Emamectin Benzoate Trunk Injection Against the Asian Long-Horned Beetle [Anoplophora glabripennis (Coleoptera: Cerambycidae)]
Authors: Wang Jian-Hong , Che Shao-Chen , Qiu Lan-Fen , Li Guang , Shao Jin-Li , Zhong Li , Zhang Guo-Feng , Xu Hoss 
Published: October 2019

Abstract
The efficacy of tree injected with emamectin benzoate (EB) against the Asian long-horned beetle (ALB) was tested in a heavily infested willow forest in Beijing, China. In a 1.7-ha plot, 240 out of 310 trees were treated with two EB formulations at various rates. After fall application, the larval population decreased by 89% in the following spring and by &gt;99% during the second year detected by monitoring new frass emission from marked holes. Consequently, the number of exit holes of emerging adults decreased to 0 in the second year. Re-infestation occurred in the third year after application. This high efficacy and lasting activity might be contributed to: a) a favorable translocation of EB in trees when injected into the sapwood; b) the high intrinsic activity against ALB larvae with LC50 of 20–30 ppb; and c) a reduced lifespan of ALB adults by over 60% when feeding on twigs of EB-treated trees. On untreated control trees, the larval population decreased during the first winter. In the second year after application, the larval population was wiped out during winter and a re-infestation started from border trees by adults flying in from outside the trial plot. This pattern indicates an eradication of the ALB population in the 1.7-ha plot can be expected 2 yr after EB treatment. The benefit of treating with EB on the surrounding population was observed in both the untreated trees and imidacloprid-treated trees, suggesting that treatment of EB benefits both the treated trees and the surrounding trees in the area.
GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors
Authors: Richardson Timothy E , Tang Karen , Vasudevaraja Varshini , Serrano Jonathan , William Christopher M , Mirchia Kanish , Pierson Christopher R , Leonard Jeffrey R , AbdelBaki Mohamed S , Schieffer Kathleen M , Cottrell Catherine E , Tovar-Spinoza Zulma , Comito Melanie A , Boué Daniel R , Jour George , Snuderl Matija 
Published: October 2019

Abstract
ROS1 is a transmembrane receptor tyrosine kinase proto-oncogene that has been shown to have rearrangements with several genes in glioblastoma and other neoplasms, including intrachromosomal fusion with GOPC due to microdeletions at 6q22.1. ROS1 fusion events are important findings in these tumors, as they are potentially targetable alterations with newer tyrosine kinase inhibitors; however, whether these tumors represent a distinct entity remains unknown. In this report, we identify 3 cases of unusual pediatric glioma with GOPC-ROS1 fusion. We reviewed the clinical history, radiologic and histologic features, performed methylation analysis, whole genome copy number profiling, and next generation sequencing analysis for the detection of oncogenic mutation and fusion events to fully characterize the genetic and epigenetic alterations present in these tumors. Two of 3 tumors showed pilocytic features with focal expression of synaptophysin staining and variable high-grade histologic features; the third tumor aligned best with glioblastoma and showed no evidence of neuronal differentiation. Copy number profiling revealed chromosome 6q22 microdeletions corresponding to the GOPC-ROS1 fusion in all 3 cases and methylation profiling showed that the tumors did not cluster together as a single entity or within known methylation classes by t-Distributed Stochastic Neighbor Embedding.