bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional threads tied on children in india trigger dermatitis and may contain carcinogens
Authors: Vijayasankar Palaniappan , Gopinath Hima , Karthikeyan Kaliaperumal 
Published: September 2020

AbstractBackground/ObjectivesIt is a common Indian custom to tie threads on the hip, neck, or wrist of infants and children.Methods/resultsA retrospective registry review was performed for 23 children (age range 5‐18 months) with threads tied around the hip/neck/forearm who presented with dermatitis. Analysis of one of the threads revealed the presence of three banned azo dyes and disperse yellow 3 (category 2B possible carcinogens).ConclusionThread dermatitis is a unique cultural dermatosis. Dermatitis caused by threads may have multifactorial causes including friction, maceration, and contact dermatitis (allergic and/ or irritant) to the thread contents. Use of banned dyes still used to color these threads may be contributory to dermatitis, but there is also concern for health and environmental hazards to children. Strict regulation is needed in the manufacture of these threads to protect the health and welfare of young children.
PS48 promotes in vitro maturation and developmental competence of porcine oocytes through activating PI3K/Akt signalling pathway
Authors: Jiao Yafei , Zhu Shaoqian , Li Jiaojiao , Jam Zaheer Ahmed , Li Mengmei , Huang Ben 
Published: September 2020

AbstractOocyte maturation plays a vitally important role in porcine reproduction. Regrettably, the quality of oocytes matured in vitro is weaker than that of in vivo matured oocytes. We collected and cultivated porcine cumulus oocyte complexes (COCs) in vitro with phosphoinositide‐dependent kinase 1 (PDK1) activator 5‐(4‐chloro‐phenyl)‐3‐phenyl‐pent‐2‐enoic acid (PS48), whose concentrations were 0, 2, 5, 10 and 20 µM to investigate whether the phosphatidylinositol‐3‐kinase/protein kinase B (PI3K/Akt) signalling pathway would impact the oocyte quality. The results showed that 10 µM PS48 increased the oocyte proportion of metaphase II (MII) stage and improved the expansion of cumulus cells (CCs). What's more, the activation of PI3K/Akt signalling pathway could regulate the expression of maturation‐related genes and proteins. The results of quantitative real‐time PCR showed that 10 µM PS48 increased the mRNA and protein levels of Akt and regulated maturation‐related genes, including cyclin B1, MOS, BMP15, GDF9, CDC2, mTOR, BAX, BCL2 and caspase‐3. The results of Western blot indicated that 10µM PS48 increased the protein abundance of Akt, phosphorylation of Akt Thr308 (p‐AktThr308) and cyclin B1, but decreased the protein abundance of pro‐apoptotic BAX. These results suggested that adding 10 µM PS48 to mature culture medium could promote the maturation of porcine oocytes, potentially through activating the PI3K/Akt signalling pathway.
Time scales of syneruptive volatile loss in silicic magmas quantified by Li isotopes
Authors: Neukampf J. , Ellis B.S. , Laurent O. , Steinmann L.K. , Ubide T. , Oeser M. , Magna T. , Weyer S. , Bachmann O. 
Published: September 2020

Abstract
Most explosive, silicic volcanoes spend thousands of years in repose between eruptive events. The timing of the switch from repose to eruption is key to interpreting monitoring signals and improving the safety of people living close to active volcanoes. We addressed this question using a novel technique based on lithium isotopic (δ7Li) and elemental concentration profiles within plagioclase crystals from the Mesa Falls Tuff of the Yellowstone volcanic system (Idaho and Wyoming, USA), constraining volatile degassing to occur on minimum time scales of tens of minutes prior to eruption. During this ephemeral time, Li abundances drop by a factor of four to 10 from crystal cores to rims, accompanied by an increase in δ7Li of as much as 10‰, reflecting diffusion-driven equilibration between plagioclase cores and outgassed, Li-poor melt. New times scales obtained in this study show the potential for rapid syneruptive changes in the volatile inventory of magmas.
High-precision geochronology requires that ultrafast mantle-derived magmatic fluxes built the transcrustal Bear Valley Intrusive Suite, Sierra Nevada, California, USA
Authors: Klein Benjamin Z. , Jagoutz Oliver , Ramezani Jahandar 
Published: September 2020

Abstract
The Bear Valley Intrusive Suite (BVIS), located in the southernmost Sierra Nevada Batholith (SNB; California, USA) exposes a transcrustal magma system consisting of lower-crustal gabbros and volumetrically extensive middle- and upper-crustal tonalites. New chemical abrasion–isotope dilution–thermal ionization mass spectrometry U-Pb geochronology shows that the bulk of this ca. 100 Ma magmatic system crystallized in 1.39 ± 0.06 m.y. and was constructed with ultrahigh magmatic fluxes (∼250 km3/km/m.y.). This magmatic flux is roughly a factor of three greater than estimates for the SNB-wide flux during the Late Cretaceous flare-up, showing that individual magmatic systems can be constructed at extremely rapid rates. Further, the Hf isotopic composition of the BVIS (εHfi ∼–2 to +4) only allows for limited (∼25%) crustal assimilation. Our results show that the high magmatic fluxes recorded in the BVIS were dominantly derived from the mantle, and that “flare-up”–like local magmatic fluxes can be produced without extraordinary assimilation of crustal material.
Demand robust counterpart open capacitated vehicle routing problem time windows and deadline model of garbage transportation with LINGO 13.0
Authors: Puspita Fitri Maya , Br. Simanjuntak Ani Sahara , Melati Rima , Octarina Sisca 
Published: September 2020

Demand robust counterpart-open capacitated vehicle routing problem with time windows and deadline (DRC-OCVRPtw,d) model formed and explained in this paper, is the model used to find the minimum distance and the time needed for vehicles to transport garbage in Sukarami Sub-District, Palembang that consists of the time it takes for the vehicle to pass through the route. Time needed to transport garbage to the vehicle is called time windows. Combination of the thoses times is called deadline. The farther
the distance passed by vehicle and the more garbage transported, the longer the deadline is needed. This DRC-OCVRPtw,d model is completed by LINGO 13.0 to obtain the optimal route and time deadline for Sukarami Sub-District. The model shows that the improved model of open vehicle routing problem involving the robustness, time windows and deadline can achieve the optimal routes that enable driver to save operational time in picking up the garbage compared to similar problem not involving no-time windows and deadline stated in previous research.
Long-term Results of Thoracic Endovascular Aortic Repair Using a Low-Profile Stent-Graft
Authors: Beropoulis Efthymios , Fazzini Stefano , Austermann Martin , Torsello Giovanni B. , Damerau Sarah , Torsello Giovanni Federico 
Published: September 2020

Purpose To evaluate the long-term results associated with the Zenith Alpha thoracic stent-graft, which was designed to address challenging access vessel anatomy. Materials and Methods A retrospective analysis was conducted of 44 consecutive patients (mean age 72.5±8.3 years; 25 men) treated in a single center between August 2010 and October 2014 with a minimum follow-up of 5 years in survivors. The Zenith Alpha thoracic stent-graft was used to treat thoracic aortic aneurysms (n=37), thoracoabdominal aortic aneurysm (n=5), or penetrating aortic ulcer (n=2). Ten patients (23%) were American Society of Anesthesiologists class IV, and 9 (20%) had nonelective procedures. Access vessel anatomy was demanding (mean minimum diameter 5.4 mm, tortuosity index 1.3). The primary endpoint at 5 years was ongoing clinical success (freedom from aneurysm-/procedure-related death, secondary intervention, type I or III endoleak, infection, thrombosis, aneurysm expansion, rupture, or conversion). Secondary endpoints were freedom from all-cause mortality, device migration, stent fractures, fabric erosions, endoleaks, neurological events, and access vessel complications. Results The ongoing clinical success was 84% (37 of 44 patients) owing to 4 aneurysm-related deaths (9%), 3 type I or III endoleaks (1 in a deceased patient), and 1 aneurysm expansion without detectable endoleak. There were 3 access vessel complications (7%), and no postoperative neurological events. Migration was observed in 2 cases (5%). There were no stent fractures or fabric tears. Conclusion Despite the alterations in stent-graft design and material to reduce profile, the Zenith Alpha thoracic stent-graft showed favorable long-term results even in multimorbid patients with demanding iliac anatomy.
Bone ingrowth into open architecture PEEK interference screw after ACL reconstruction
Authors: Lind Martin , Nielsen Torsten , Sørensen Ole Gade , Mygind-Klavsen Bjarne , Faunø Peter , Leake-Gardner Stacy 
Published: September 2020

Abstract
Purpose
Open or fenestrated interference screw design that allow bone ingrowth is a concept for improved bone healing to softtissue graft and bone filling in bone tunnels after anterior cruciate ligament reconstruction (ACLR) The aim of the current study was to assess CT scanning evaluated bone ingrowth into an open architecture interference screws in the tibial tunnel of patients undergoing ACL with soft tissue grafts. It was hypothesized that open architecture interference screws would stimulate bone ingrowth into the screw cavities.

Methods
Twelve patients requiring ACLR were included. They underwent arthroscopic ACLR with semitendinosus−/gracilis tendon graft and an open architecture polyetheretherketone (PEEK) interference screw. The patients were scanned with a multi-slice CT scanner two weeks, six and twelve months postoperatively. On CT reconstruction slices bone ingrowth into the screw was measured. Subjective and objective clinical outcome international knee documentation committee score and instrumented knee laxity determination were collected.

Results
At six months no implants demonstrated more than 10% bone ingrowth. At twelve months 42% (5/12) implants had more than 10% bone ingrowth (p = 0.009). The average bone filling into the screws was 7.7%. There was no tunnel widening or cyst formation seen in relation to any of the implants. Subjective IKDC score improved significantly from 50.6 baseline to 80.1 at 24 month follow-up. Preoperative side-to-side knee laxity improved from 3.7 (2.1) to 1.4 (1.2) mm at twelve months. There were no serious adverse events in relation to the new open architecture thread PEEK interference screw during or after hamstring ACL reconstruction.

Conclusion
The present study demonstrated that open architecture thread PEEK interference screw can stimulate bone ingrowth into the screws after soft tissue ACL reconstruction with at 12 months with an average bone filling into screws was 7.7%. Knee stability, functional, subjective and objective outcomes were similar to large volume ACL outcome studies.

Trial registration
The study was registered at ClinicalTrials # NCT02382341. 12-09-2014.

Level of evidence
IV.
Soluble human leukocyte antigen-G evaluation in pregnant women with gestational diabetes mellitus
Authors: Abdel Hameed Muhamad R. , Ibrahiem Osama Ahmed , Ahmed Entsar Hamed , Sedky Paula Rofaeel , Mousa Naglaa Mohamed M. A. 
Published: September 2020

Abstract
Background
Gestational diabetes mellitus is any degree of glucose intolerance with onset or first recognition occurring late in second trimester and third trimester of pregnancy. It constitutes a greater impact on diabetes epidemic as it carries a major risk for developing type 2 diabetes mellitus to the mother and her fetus later in life. human leukocyte antigen (HLA)-G is a class Ib gene presents in the human major histocompatibility complex (MHC). HLA-G has an important role for mother and fetus tolerance during pregnancy, also in the pancreatic islet cells protection. This is a case-control study, measuring serum HLA-G levels by ELISA in 60 pregnant women with gestational diabetes compared with 36 normal pregnant women.

Results
HLA-G levels were significantly high in pregnant women with gestational diabetes mellitus (GDM) in contrast to women with normal pregnancy (P = 0.001).

Conclusion
Women with GDM had significantly higher levels of soluble HLA-G than women without GDM, suggesting that HLA-G molecule is among the factors for regulation and control of the immune response and the induction of tolerance. Soluble HLA-G could be considered an important follow-up investigation for all pregnant primary health care for early detection of gestational diabetes.
Next Generation Multifunctional Nano-Science of Advanced Metal Complexes with Quantum Effect and Nonlinearity
Authors: Yamashita Masahiro 
Published: September 2020

AbstractMy research target can be described as “Next Generation Multifunctional Nano-Science of Advanced Metal Complexes with Quantum Effect and Nonlinearity”. My work encompasses four important key areas: (1) inorganic-organic hybrid systems, (2) nano-size and nano-space, (3) bottom-up and self-assembly, and (4) nonlinearity and quantum effect. Among them, nonlinearity and quantum effect are the most important for nano-science of advanced metal complexes. I have been working on these two topics (nonlinearity and quantum effect) simultaneously for more than 40 years. As for quantum effect, I have focused on Haldane gap systems, single-chain magnets (SCMs), single-molecule magnets (SMMs), Kondo resonance on SMMs, photo-switchable SMMs, metallic conducting SMMs, SMMs encapsulated into single-walled carbon nanotube (SWCNT), and metal-organic framework (MOF)-spintronics for spin qubits, for pursuing high-density memory devices and quantum computing. As for nonlinearity, I have focused on quasi-one-dimensional halogen-bridged metal complexes (MX-Chains; M = Pt, Pd, and Ni; X = Cl, Br, and I) with nonlinear excitons such as solitons and polarons, strongly electron-correlated Ni(III) complexes with gigantic third-order optical nonlinearity, and phase transitions and charge fluctuations between Pd(III) averaged states (= Mott insulator) and Pd(II)-Pd(IV) mixed-valence states (= charge density wave states), for pursuing optical communication, optical switching, and optical computing. In this review article, I will describe the above main topics (quantum effect and nonlinearity) according to my research history of more than 40 years, respectively. Finally, I will propose future perspectives for the two topics.
Irritable bowel syndrome dietary modifications - what to forbid and what to recommend?
Authors: Kaczyńska Agnieszka , Wieteska Małgorzata , Stanicki Paweł , Szarpak Julita 
Published: September 2020

Irritable bowel syndrom is a gastrointestinal disorder, that affects about 10 % of worlds population. The etiology remains unclear, however studies show, that bad dietary habits may aggravate the symptoms. The most frequent signs of IBS are: abdominal pain, bloating, constipation, diarrhea and change in bowel habits. The aim of this study was to describe dietary modifications that can alleviate the symptoms and improve patients quality of life. The study material consisted of publications, that we’ve found on databases as PubMed, ResearchGate and Google Scholar. Patients find out, that certain food aggravate the symptoms. The most frequent triggering factors are: coffee, diary products, alcohol, spicy foods and lipids. Our review shows, there are some recommendations that help patients in their everyday diet change. For example drinking at least 3 cups of coffee per day can reduce bloating and diarrhea, while drinking more than 1,5 L of other fluids per day can alleviate symptoms as constipation. According to studies, following a IBS diet can minimize the signs. Moreover, recently developed „IBS food pyramid” is based on actual recommendations and knowledge a visual and user-friendly tool helping patients in everyday diet changes.Unfortunately, still there is insufficient evidence of studies about dietary approaches. Well designed and randomized control trials are needed to improve efficacy, safety and knowledge about dietary modifications.
Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats
Authors: Popadynets’ Oleksandr , Bilas Volodymyra , Flyunt Igor-Severyn , Badiuk Nataliya , Zukow Walery , Gozhenko Anatoliy , Popovych Igor 
Published: September 2020

Background. We have previously shown that the Entropy (E) of the Thymocytogram (T), Splenocytogram (S) as well as Leukocytogram (L) and Immunocytogram (I) of the blood in rats are virtually independent of each other. The purpose of this study was to clarify the characteristics of the condition of the neuroendocrine-immune complex in different constellations of E(s) of these four morpho-functional immune subsystems. Materials and methods. Experiment was performed on 108 healthy Wistar rats (48 male and 60 female) weighing 240-290 g divided into 8 groups. Animals of the first group remained intact. Instead, the other rats received various balneofactors for 6 days. The day after the completion of the drinking/application course the parameters of neuroendocrine-immune complex were registered. Results. The method of cluster analysis created four homogeneous groups of rats, significantly different from each other in the constellation of E of four morpho-functional immune subsystems. The members of the first cluster (n=31) are characterized by elevated levels of E (Z±SE) of I (1,12±0,16), T (1,00±0,14) and L (0,88±0,12) at the normal E level of S (0,14±0,16). The members of the second cluster (n=21) are characterized by reduced E level of L (-1,59±0,16) in combination with increased levels of I (0,80±0,17) and T (0,81±0,15) at the normal E level of S (0,13±0,16). A characteristic feature of the members of the third cluster (n=28) is reduced E of T (-1,01±0,17) at normal E levels of S (-0,33±0,23), I (-0,19± 0,14 ) and L (0,35±0,20). The last cluster (n=28) is characterized by reduced E of I (-1,36± 0,14), while the E of other immune subsystems are at the borderline levels: L (-0,52±0,16), S (0,49±0,15), T (0,60±0,15). The method of discriminant analysis revealed 15 parameters of the neuroendocrine-immune complex, the set of which four clusters of Entropies differ from each other with an accuracy of 95%. Conclusion. Each constellation of independent Entropies of the thymocytogram, splenocytogram, immunocytogram and leukocytogram is accompanied by a specific constellation of parameters of the neuroendocrine-immune complex which indicates their natural functional relationships.
The impact of pregnancy on a woman's health - stress urinary incontinence
Authors: Fortuna Aleksandra , Lipka Marta , Kędziora-Kornatowska Kornelia 
Published: September 2020

Introduction: Urinary incontinence is an embarrassing problem that affects more and more women. The most common type of incontinene in women is stress urinary incontinence, which is defined as the involuntary loss of urine caused by an abnormal closure of the urethra. It happens most often during exercise, coughing or sneezing. The problem of urinary incontinence is extremely important due to the accompanying impact on the psyche of women. It causes a disturbance of self-esteem and is often a cause of embarrassment before visiting a doctor. Results: The pathogenesis of urine loss is multifactorial, but in recent times a lot of blame has been placed on the changes taking place in the body during pregnancy and childbirth. Childbirth weakens the pelvic floor muscles, causing temporary or permanent urine loss. The diagnosis of urinary incontinence is based on the basis of a carefully collected medical history, physical examination and additional tests. Conclusion: Physiotherapeutic procedures, pharmacological treatment and surgical treatment are used as a therapeutic procedures. Prophylactic pelvic floor muscle exercises also play an important role. The most popular treatment for stress urinary incontinence is physiotherapy, including Kegel exercises. The awareness of women about the problem of urinary incontinence should be increased to prevent them from limiting their daily activities and deteriorating sexual activity.
Study on the state of knowledge of medical students about the glycemic index of popular food products in Poland. A survey study
Authors: Czarnota Jakub , Dobrzyński Michał , Skubel Tomasz , Drozd Małgorzata , Dudek Iga , Sokół Dorota , Piecewicz-Szczęsna Halina 
Published: September 2020

Introduction: The glycemic index (GI) is a helpful indicator in composing a healthy diet, especially for people at risk of carbohydrate metabolism disorders. High GI products are quickly digested and absorbed in the human body. There is a sharp increase in postprandial glucose and insulin secretion, followed by a rapid decrease in blood glucose level, which results in increased glucagon secretion and increased appetite. A high GI diet may be one of the causes of insulin resistance and obesity.Aim: The aim of the study is to examine the state of knowledge of medical students studying in Poland about the glycemic index of popular food products.Material and Methods: An anonymous online survey was conducted. The answers of 140 medical students of polish medical universities were analyzed.Results: Despite the fact that 52.1% of respondents declared that they are interested in the subject of healthy eating, milk chocolate and honey were most often recognized as high GI by the respondents (respectively 90.6% and 84,1% of answers). However, these products are classified as low/medium GI products. A baguette with a very high GI obtained 70.3% of responses. Another product with a medium Gi, boiled potatoes, got 56.5% response.Conclusion: The knowledge of medical students about the glycemic index is not large, despite expressed interest in the subject of healthy eating.
Sports massage as a method of preventing delayed onest muscle soreness
Authors: Choroszewicz Paweł , Dobosiewicz Anna Maria , Badiuk Nataliia 
Published: September 2020

Physical activity, despite it’s many advantages for health and fitness, can have negative effects on humans. One of them may be delayed muscle soreness (DOMS), which appears 48-72 hours after the end of training. People performing intensive training, performing eccentric exercises, as well as people who take up activity once in a while are exposed. DOMS can meet both qualified athletes and amateurs of sport.
There is a collage of hypotheses explaining the formation of delayed muscle soreness. The most recent one is that DOMS is the result of muscle micro-injuries. There is also no single effective method of pain treatment. Pharmacology, hot and cold treatment methods, stretching and massage are applied. Research on athletes as well as amateur athletes shows that sports massage leads to faster regeneration of muscles affected by DOMS.