bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation – a pilot study in porcines
Authors: Abood Ahmed A. , Møller-Madsen Bjarne , Shiguetomi-Medina Juan Manuel , Stødkilde-Jørgensen Hans , Foldager Casper , Rahbek Ole 
Published: October 2020

Purpose The article compares physeal recovery after insertion of autologous cartilage and a conventional fat graft in a standardized porcine physeal gap model. Presence of a bone bridge was the primary outcome. Methods Ten porcines in two groups of five were included in a paired design. A standardized physeal gap in the distal femur was made in all animals. One group (n = 5) was randomized for deposition of autologous cartilage and a Tisseel® or Tisseel® alone. The autologous cartilage was harvested from the femoral articular surface. The other group was randomized for fat grafting or no grafts at all. All animals were housed for 14 weeks. Magnetic resonance imaging (MRI) was performed at 14 weeks prior to euthanasia. The physis was harvested for histology. Results MRI – Three bone bridges were seen in the fat grafted gaps. All empty gaps formed a bone bridge. No gaps filled with autologous cartilage and Tisseel® resulted in bone bridges. One gap filled with Tisseel® only caused a bone bridge. Histology – The cartilage grafted gaps recovered with physeal-like cartilaginous tissue in histological analysis. Conclusions Fat grafts seems ineffective in preventing bone bridges. The use of autologous cartilage may be superior to the current treatment. However, donor site complications were not investigated. The study serves as a proof of concept study and requires further investigation. Level of evidence III
Vascular examination predicts functional outcomes in supracondylar humerus fractures: A prospective study
Authors: Ernat Justin J. , Wimberly Robert L. , Ho Christine A. , Riccio Anthony I. 
Published: October 2020

Purpose This article prospectively examines the functional outcome measures following management of vascular insult secondary to paediatric supracondylar humerus fractures (SCHFX) using validated outcome measures. Methods The three-year, prospective, IRB-approved study consecutively enrolled operative SCHFX patients. Clinical data included presence and symmetry of the radial pulse in injured and uninjured extremities, Doppler examination of non-palpable (NP) pulses and perfusion status of the hand. Pediatric Outcomes Data Collection Instruments (PODCI) and the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) Measures were used to assess functional outcome at final follow-up. Multiple regression analysis was used to determine the relationship between the presence of a vascular abnormality and functional outcome while controlling for other injury parameters. Results A total of 146/752 enrolled patients (mean age 6.8 years; range 2 years to 13 years) completed functional outcome measures at final follow-up. Of these, 20 (14%) patients had abnormal vascular exams at presentation: nine (6%) with palpable asymmetric pulse and 11 (7.5%) with NP pulse. Of those with NP pulses, nine/11 (6%) were Dopplerable and two (1.5%) lacked identifiable Doppler signal. Patients with a symmetric, palpable pulse demonstrated better PODCI pain and comfort scores (95.2 versus 85.2) (p < 0.0001), and QuickDASH scores (10.9 versus 21.6) (p < 0.007) compared to those with any abnormal vascular examination. Patients with palpable pulses, regardless of symmetry, demonstrated ­significantly higher PODCI pain and comfort scores (94.6 versus 84.7) (p < 0.003) than NP pulses. Conclusions In children with operative SCHFX, an abnormal vascular examination at presentation is predictive of poorer outcomes in pain and upper extremity function. A palpable pulse, versus NP, is predictive of better pain and comfort at final follow-up. Level of evidence II
Half-threaded holes markedly increase the fatigue life of locking plates without compromising screw stability
Authors: Chao Ching-Kong , Chen You-Lin , Lin Jinn 
Published: October 2020

Aims To determine whether half-threaded screw holes in a new titanium locking plate design can substantially decrease the notch effects of the threads and increase the plate fatigue life. Methods Three types (I to III) of titanium locking plates were fabricated to simulate plates used in the femur, tibia, and forearm. Two copies of each were fabricated using full- and half-threaded screw holes (called A and B, respectively). The mechanical strengths of the plates were evaluated according to the American Society for Testing and Materials (ASTM) F382-14, and the screw stability was assessed by measuring the screw removal torque and bending strength. Results The B plates had fatigue lives 11- to 16-times higher than those of the A plates. Before cyclic loading, the screw removal torques were all higher than the insertion torques. However, after cyclic loading, the removal torques were similar to or slightly lower than the insertion torques (0% to 17.3%), although those of the B plates were higher than those of the A plates for all except the type III plates (101%, 109.8%, and 93.8% for types I, II, and III, respectively). The bending strengths of the screws were not significantly different between the A and B plates for any of the types. Conclusion Removing half of the threads from the screw holes markedly increased the fatigue life of the locking plates while preserving the tightness of the screw heads and the bending strength of the locking screws. However, future work is necessary to determine the relationship between the notch sensitivity properties and titanium plate design. Cite this article: Bone Joint Res 2020;9(10):645–652.
Uso do Marketing Digital: Uma Análise de Empresas de um Parque Tecnológico
Authors: Victorino Karoline , Sordi Jefferson Dobner , Gonçalves Manuela Albornoz , Rauber Luis Henrique , Jahn Nivia Maria 
Published: October 2020

Objetivo - entender como as pequenas empresas localizadas em um parque tecnológico fazem uso de ações estratégicas e ferramentas de marketing digital para promover seus negócios.Metodologia/abordagem - sistematizou-se uma coleta de dados exploratória com abordagem qualitativa através de entrevistas em profundidade com empresários do parque tecnológicoPrincipais resultados - A pesquisa demonstrou que os empreendedores apresentam dificuldades na formação e execução de estratégias de marketing digital. O conhecimento que cada empreendedor tem de cada ferramenta tem reflexos no uso que ele faz das ferramentas disponíveis.Contribuições teóricas/metodológicas - Construiu-se um framework demonstrando de que forma as pequenas empresas executam suas estratégias de marketing digital do papel que o conhecimento das ferramentas e métricas tem no uso e nas ações executadas pelas organizações.Relevância/originalidade - Viu-se a oportunidade de entender como empresas inseridas em ambientes de inovação utilizam as diversas ações estratégicas que o marketing digital oferece e como elas realizam o devido monitoramento das ações realizadasContribuições sociais / para a gestão - A partir do trabalho, os gestores de pequenos negócios podem reconhecer quais são as barreiras que encontram para execução de estratégias de marketing digital e buscarem soluções para superar esses desafios, à luz do seu conhecimento e potenciais reflexos nos negócis.
Self-Reported Lower Gastrointestinal Endoscopy Use and Changes in Colorectal Cancer Mortality Rates in European Countries
Authors: Chen Chen , Stock Christian , Hoffmeister Michael , Brenner Hermann 
Published: October 2020

INTRODUCTION:
To quantify the association of self-reported lower gastrointestinal endoscopy use measured in 2004/05 with colorectal cancer (CRC) mortality changes over 2004–2015 in Europe.

METHODS:
An ecological analysis was performed using endoscopy utilization data from the Survey of Health, Aging, and Retirement in 11 European countries in 2004/05 and CRC mortality data from the World Health Organization Mortality Database over 2004–2015. Mortality trends were compared through annual mortality changes from joinpoint regression models. Cross-national variations in mortality trends with respect to endoscopy use were tested for statistical significance by negative binomial regression models.

RESULTS:
The proportion of respondents who reported having had an endoscopy within 10 years varied widely across countries, from 6.1% to 25.1%. Large disparities in CRC mortality trends were also observed, with annual mortality change ranging from a decline of 3.3% to an increase of 0.9% for men and from a decline of 3.3% to a decline of 0.6% for women. Endoscopy uptake was negatively associated with the magnitude of annual mortality change over 2004–2015 (rate ratio for a 10-year mortality change per 10% higher endoscopy use, 0.88; 95% confidence interval, 0.82–0.94).

DISCUSSION:
This analysis provides quantitative evidence on the contributions of endoscopy use to CRC mortality declines in European countries over the past decade. A considerable fraction of protection is likely to be delivered through endoscopic removal of adenomas and sessile serrated lesions. With many European countries having recently implemented CRC screening programs, an increase in endoscopy use and a subsequent reduction in CRC mortality would be expected.
Polymorphism of 5’UTR myostatin gene indel (g.1256/TTTTA) and its association with body weight in Boerka crossbred goat
Authors: Ismail R. , Handiwirawan E. , Elieser S. , Jakaria J. 
Published: October 2020

This study aimed to identify the variation of 5’UTR Myostatin (MSTN) gene and its association to body weight in Boer, Kacang, and Boerka goats. DNA samples were obtained from 149 heads of the goats from the Indonesian Goat Research Center, Sungei Putih, North Sumatera. Polymorphism identification was conducted by direct sequencing and PCR-RFLP with DraI as the restriction enzyme for indel g.1256/TTTTA. Analysis of variance for body weight was carried out using the General Linear Model (GLM). The 5’UTR MSTN gene|DraI was monomorphic in Kacang but polymorphic in Boer and Boerka. Genotype frequencies for Boer 0.40(AA), 0.43(AB), 0.17(BB); Kacang 1.00(AA); Boerka 0.53(AA), 0.37(AB), 0.10(BB). The allele frequencies for Boer 0.62(A), 0.38(B); Kacang 1.00(A); Boerka 0.72(A), 0.28(B), respectively. AB was the most frequent genotype among Boer, but AA was the most frequent in Kacang and Boerka. Indel g.1256/TTTTA has a significant effect (P<0.05) only on birth weight (BW) of Boer, but no significant effect on other bodyweight parameters both in Boer and Boerka.AA genotype has the highest BW (P<0.05) than AB, but it’s not significantly different from BB. Indel g.1256/TTTTA could be used as a genetic marker for the birth weight of Boer but not in Boerka goats.
Effect of addition an amino acid or its combination with EDTA on DNA integrity and morphometry sperm heads of freeze-dried bovine spermatozoa
Authors: Said S. , Maulana T. , Setiorini S. , Ibrahim G.E. , Ramadhan M.N. , Christopher E. 
Published: October 2020

The objective of the current study was to investigate the effect of addition an amino acid or its combination with EDTA on DNA integrity and morphometry sperm heads of freeze-dried bovine spermatozoa. Spermatozoa were freeze-dried in medium with the addition of an amino acid glycine, cysteine, glutamine, or its combination with EDTA. Sperm head morphometry was identified at 400X magnification using Axio Vision(Zeiss Company, Germany), while for membrane plasma integrity (MPI) determined by calculation of the percentage of spermatozoa having intact plasma membrane by osmotic resistance test method and DNA integrity analysis using acridine orange staining. Sperm head had declined in size after the freeze-drying process, MPI of FD spermatozoa gradually increased significantly when FD solution was added with an amino acid solution (glycine, cysteine) and its combination with EDTA. DNA integrity of all freeze-dried spermatozoa treatments was remaining intact, no significantly different (P>0.01) among treatments. The present study concluded that the addition of an amino acid (glycine, cysteine) or its combination with EDTA could be reduced morphometric sperm heads and plasma membrane damage of freeze-dried bovine spermatozoa, however, DNA integrity of bovine sperm nucleus remaining intact after the freeze-drying process without addition both amino acids and EDTA.
»Vojna není kojná«, czyli koszarowy humor w warunkach totalitaryzmu
Authors: BALOWSKA Grażyna 
Published: October 2020

Artykuł prezentuje językowe sposoby osiągania efektu komicznego przez Milo- slava Švandrlíka w powieści humorystycznej Černí baroni. Są to m.in. łączenie elementów z różnych odmian języka czeskiego (spisovná čeština, obecná čeština, gwary) lub czeszczyzny i języka słowackiego, wprowadzanie wulgaryzmów, słownictwa skatologicznego i inwektyw do języka propagandy totalitarnej, kontrast formy i treści, paralelizm składniowy. Podkreślone zostają istotne funkcje społeczne śmiechu jako reakcji na humor szczególnie w trudnym czasie życia społecznego, jakim był okres komunistyczny, np.: terapeutyczna, integracyjna i separująca.
Inverse design of diffractive optical elements using step-transition perturbation approach
Authors: Kim Dong Cheon , Hermerschmidt Andreas , Dyachenko Pavel , Scharf Toralf 
Published: October 2020

Abstract
Diffractive optical elements are ultra-thin optical components required for a variety of applications because of their high design flexibility. We introduce a gradient-based optimization method based on a step-transition perturbation approach which is an efficient approximation method using local field perturbations due to sharp surface profile transitions. Step-transition perturbation approach be available to calculate the gradient of figure of merit straightforwardly, we implemented optimization method based on this gradient. This fast and accurate inverse design creates binary (2-level) diffractive elements with small features generating the wide angle beam arrays. The results of the experimental characterization confirm that the optimization based on the perturbation method is valid for 1-to-117 fan-out grating generating beam pattern of linear array.
Performance evaluation of AF-relayed mixed FSO/mm-wave-RF link modeled by generalized misalignment and RF fading distributions
Authors: Khanna Himanshu 
Published: October 2020

Abstract
The performance of a generalized mixed free-space-optical (FSO)/millimeter (mm)-wave radio-frequency (RF) two-hop link model is investigated in this work. The first-hop FSO channel considers the influence of path loss, atmospheric turbulence which is modeled by the gamma–gamma (GG)-distribution, and generalized misalignment errors which incorporate the effects of non-zero boresight errors, different jitter standard deviations along the horizontal and vertical directions, and correlation between the horizontal and vertical displacements. The second-hop RF link is modeled by an extended-generalized-K (EGK) distribution which is a versatile distribution and can characterize various fading conditions in mm-wave wireless channels where the transmission frequency is in excess of 60 GHz, and considers non-homogeneous propagation, interference effects due to multiuser transmission, multipath fading and shadowing effects observed in mm-wave RF wireless channels. The considered system employs fixed-gain amplify-and-forward (AF) relay-assisted transmission. The statistical characteristic for the end-to-end SNR, i.e., cumulative distribution function (cdf), is obtained for the considered system model in this work. Based on the obtained result for cdf, the outage and error performance is evaluated, and closed form expressions for the same are derived. The derived analytical results have been illustrated through numerical plots.
Do political parties matter? Evidence from German municipalities
Authors: Riedel Nadine , Simmler Martin , Wittrock Christian 
Published: October 2020

Abstract
We assess whether the partisanship of local councils affects the level and composition of local public spending by German municipalities. Our identification strategy exploits changes in the party with the absolute majority in the local council, combining an instrumental variable strategy with a matching approach to address potential selection into treatment. We find evidence for strong partisan effects: Communities with a left-wing council majority spend more on ‘people-oriented’ public goods and less on infrastructure than communities with a right-wing dominated council.
Comprehensive study on the effects of process parameters of alkaline thermal pretreatment followed by thermomechanical extrusion in sugar liberation from Eucalyptus grandis wood
Authors: Doménech Pablo , Manzanares Paloma , Álvarez Cristina , Ballesteros Mercedes , Duque Aleta 
Published: October 2020

Abstract
A combination of alkaline thermal pretreatment followed by thermomechanical extrusion was studied as a novel sequential pretreatment process for an effective breakdown of the lignocellulosic structure of Eucalyptus grandis wood (EW). The first step was studied by analysing the influence of two factors: the NaOH-to-dry biomass ratio or NaOH loading (NaOH/DM) and the liquid-to-solid ratio (L/S). Optimization of these two parameters provided good results in terms of enzymatic hydrolysis at 5% (w w−1) solids loading, obtaining a total sugar concentration of 24.9 g L−1 and a total sugar production of 36.9 g 100 g−1 raw EW after pretreating the biomass at 20% NaOH/DM and L/S = 1/1. The second step of extrusion, when followed by a final washing step, provided a significant increase in glucose and xylose production when working at 10% NaOH/DM. For a soda loading of 20%, there was a clear improvement in sugars conversion yield after extrusion and washing: 71% for glucan conversion and 89% for xylan.
Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
Authors: Knabben Laura , Siegenthaler Franziska , Imboden Sara , Mueller Michael D. 
Published: October 2020

Abstract

Objectives
Genetic testing rates for hereditary breast and ovarian cancer (HBOC) have steadily increased during the past decades resulting in a growing population of young and healthy mutation carriers. Available data on fertility issues in BRCA mutation carriers is rising but the results remain to some extent still conflicting.
We have performed a systematic literature review in order to get an overview concerning the current evidence on fertility issues in BRCA mutation carriers. Data were analyzed critically with the aim to deliver physicians a solid basis for (onco) fertility counseling in women with BRCA mutations.

Content
We present the latest data on cancer risks in women with HBOC and analyze the influence of cancer treatment and preventive surgery on the reproductive potential. Epidemiological studies on fertility issues in BRCA mutation carriers showed heterogeneous results. However, several authors showed a decreased ovarian reserve with lower Anti-Müllerien hormone (AMH) levels and poorer response to ovarian stimulation in BRCA positive women. The diagnosis of BRCA mutations influences reproductive decision-making. Additionally, the shortened reproductive window and the need to complete family planning early has a significant psychological impact.

Summary and Outlook
This article highlights the importance of fertility counseling in BRCA mutation carriers. Individual fertility counseling is mandatory. Fertility preservation strategies should be discussed.
Microwave thermometry with potential application in non-invasive monitoring of hyperthermia
Authors: Ghaderi Aram Morteza , Beilina Larisa , Dobsicek Trefna Hana 
Published: October 2020

Abstract
Integration of an adaptive finite element method (AFEM) with a conventional least squares method has been presented.
As a 3D full-wave forward solver, CST Microwave Studio has been used to model and extract both electric field distribution in the region of interest (ROI) and S-parameters of a circular array consisting of 16 monopole antennas.
The data has then been fed into a differential inversion scheme to get a qualitative indicator of how the temperature distribution evolves over a course of the cooling process of a heated object.
Different regularization techniques within the Tikhonov framework are also discussed, and a balancing principle for optimal choice of the regularization parameter was used to improve the image reconstruction quality of every 2D slice of the final image.
Targets are successfully imaged via proposed numerical methods.
Occupational exposure in lead and zinc mines induces oxidative stress in miners lymphocytes: Role of mitochondrial/lysosomal damage
Authors: Seydi Enayatollah , Soltani Mahshid , Ramazani Maral , Zarei Mohammad Hadi , Pourahmad Jalal 
Published: October 2020

Abstract
The purpose of this research was to determine mitochondrial and lysosomal damage and oxidative stress status in blood lymphocytes of lead-zinc miners. This research was performed in 10 mine workers who have been in contact with lead and zinc in comparison to a control group containing 10 healthy volunteers. Lymphocytes were isolated from peripheral blood using the Ficoll standard method and then mitochondrial and lysosomal damage and oxidative stress were evaluated. The level of reactive oxygen species (ROS), collapse in the mitochondrial membrane potential (MMP) collapse, and glutathione disulfide (GSSG) content, and lysosomal damage in miners were higher than the control group. Also, viability and glutathione (GSH) content were decreased. The lymphocytes of workers of a lead-zinc mine are more susceptible to oxidative stress, mitochondrial and lysosomal damage. The proper use of safety equipment can reduce the risk of toxic agents and their subsequent hazards for mine workers.
Novel multi-zone self-heated composites tool for out-of-autoclave aerospace components manufacturing
Authors: Jayasree Nithin , Omairey Sadik , Kazilas Mihalis 
Published: October 2020

Abstract
In this paper, a multi-zone self-heating composite tool is developed to manufacture out-of-autoclave complex and high-quality business jet lower wing stiffened composite panel. Autoclave manufacturing is regarded as a benchmark for manufacturing aerospace-grade composite parts. However, high accruing operational costs limit production rates thereby not being practical for smaller-scale companies. Therefore, significant work towards developing out-of-autoclave manufacturing is underway. In this study, a production line tool is developed with embedded heating fabric that controls temperature at the desired zones, replacing the need for autoclave cure. It investigates and identifies the optimal design parameters of the self-heating setup namely the placement of the heating fabric, zones, thermal management system, temperature distribution, heating rate and thermal performance using a thermal FEA model. The associated thermal characterisation of the tooling material and the part are measured for accurate simulation results. The design developed in this study will be used as production guideline for the actual tool.
Zwischen Systemrelevanz und Lebens- relevanz: (Religionspädagogische) Relevanzsetzungen und deutungsmacht- sensible Relevanzaushandlungen in der Corona-Krise
Authors: Kumlehn Martina 
Published: October 2020

Zusammenfassung
Der Artikel stellt wesentliche Deutungsprozesse und Strategien der Relevanzsetzung verschiedener Akteure in der Corona-Krise dar. Er reflektiert vor diesem Hintergrund wesentliche Aspekte einer relevanzorientierten Religionspädagogik. Dabei erscheint Relevanz als multifaktorielles Konstrukt. Schließlich werden konkrete didaktische Impulse für religiöse Bildungsprozesse im Kontext der Corona-Krise entworfen.