bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI technology for remote clinical assessment and monitoring
Authors: Zoppo Gianluca , Marrone Francesco , Pittarello Monica , Farina Marco , Uberti Alberto , Demarchi Danilo , Secco Jacopo , Corinto Fernando , Ricci Elia 
Published: December 2020

Objective: To report the clinical validation of an innovative, artificial intelligence (AI)-powered, portable and non-invasive medical device called Wound Viewer. The AI medical device uses dedicated sensors and AI algorithms to remotely collect objective and precise clinical data, including three-dimensional (3D) wound measurements, tissue composition and wound classification through the internationally recognised Wound Bed Preparation (WBP) protocol; this data can then be shared through a secure General Data Protection Regulation (GDPR)- and Health Insurance Portability and Accountability Act (HIPAA)-compliant data transfer system. This trial aims to test the reliability and precision of the AI medical device and its ability to aid health professionals in clinically evaluating wounds as efficiently remotely as at the bedside. Method: This non-randomised comparative clinical trial was conducted in the Clinica San Luca (Turin, Italy). Patients were divided into three groups: (i) patients with venous and arterial ulcers in the lower limbs; (ii) patients with diabetes and presenting with diabetic foot syndrome; and (iii) patients with pressure ulcers. Each wound was evaluated for area, depth, volume and WBP wound classification. Each patient was examined once and the results, analysed by the AI medical device, were compared against data obtained following visual evaluation by the physician and research team. The area and depth were compared with a Kruskal–Wallis one-way analysis of variations in the obtained distribution (expected p-value>0.1 for both tests). The WBP classification and tissue segmentation were analysed by directly comparing the classification obtained by the AI medical device against that of the testing physician. Results: A total of 150 patients took part in the trial. The results demonstrated that the AI medical device's AI algorithm could acquire objective clinical parameters in a completely automated manner. The AI medical device reached 97% accuracy against the WBP classification and tissue segmentation analysis compared with that performed in person by the physician. Moreover, data regarding the measurements of the wounds, as analysed through the Kruskal–Wallis technique, showed that the data distribution proved comparable with the other methods of measurement previously clinically validated in the literature (p=0.9). Conclusion: These findings indicate that remote wound assessment undertaken by physicians is as effective through the AI medical device as bedside examination, and that the device was able to assess wounds and provide a precise WBP wound classification. Furthermore, there was no need for manual data entry, thereby reducing the risk of human error while preserving high-quality clinical diagnostic data.
Maggot debridement therapy in critical limb ischaemia: a case study
Authors: Maeda Taku , Yamamoto Yuhei , Murao Naoki , Hayashi Toshihiko , Kimura Chu , Matsui Suguru , Saito Tatsuya , Matsui Hotaka , Osawa Masayuki , Funayama Emi 
Published: December 2020

Objective: In critical limb ischaemia (CLI), first-line therapy is revascularisation, but alternative treatment options are needed in certain cases. Maggot debridement therapy (MDT) is historically considered to be contraindicated in ischaemic ulcers. Wound care in patients with CLI is becoming increasingly diverse with the development of novel revascularisation strategies; therefore, CLI now needs to be reconsidered as an indication for MDT. Method: We retrospectively reviewed five legs with CLI (five male, one female) treated with MDT between January 2013 and December 2017. Changes in skin perfusion pressure (SPP) around the ulcer before and after MDT were evaluated. One or two cycles of MDT were performed (eight in total). We also evaluated the proportion of necrotic tissue in the ulcer and the presence of exposed necrotic bone. The proportion of necrotic tissue in the ulcer was classified as NT 1+ (<25%), NT 2+ (25–50%), NT 3+ (50–75%) or NT 4+ (>75%). Results: When the proportion of necrotic tissue was >50%, with no exposed necrotic bone in the wound, an increase in SPP was observed after five (62.5%) of eight cycles of MDT. And with a proportion of necrotic tissue of <25% and/or exposed necrotic bone in the wound, a decrease in SPP was observed after three (37.5%) of eight cycles. Wound healing was accelerated in the presence of increased SPP. Conclusion: Effective MDT with increased SPP requires an ulcerative state of necrotic tissue grade > NT 3+, with no exposed necrotic bone.
Development and Sensitivity Analysis of an Online Tool for Evaluating Drainage Water Recycling Decisions
Authors: Reinhart Benjamin D. , Frankenberger Jane R. , Hay Christopher H. , Bowling Laura C. , Hancock Benjamin G. 
Published: December 2020

HighlightsA modeling framework for drainage water recycling (DWR) was developed to estimate irrigation and water quality benefits.Global sensitivity analysis was used to identify most and least influential input parameters affecting model outputs.Parameters controlling total available water had the most influence on applied irrigation and captured tile drain flow.The modeling framework and sensitivity results were used to develop an open-source, online tool for evaluating DWR.Abstract. The U.S. Midwest is experiencing growth in both irrigation and subsurface (tile) drainage. Capturing, storing, and reusing tile drain water, a practice called drainage water recycling (DWR), represents a strategy for supporting supplemental irrigation while also reducing nutrient loads in tile-drained landscapes. This article describes the development and testing of an open-source online tool, Evaluating Drainage Water Recycling Decisions (EDWRD), which integrates soil and reservoir water balances for a tile-drained field and estimates potential benefits of DWR systems across multiple reservoir sizes. Irrigation benefits are quantified by applied irrigation and its relation to the irrigation demand, while water quality benefits are quantified by the amount and percentage of tile drain flow captured by the reservoir. Global sensitivity analysis identified input parameters affecting total available water as the most influential factors in estimating outputs. Initial and mid-season crop coefficients, irrigation management, and reservoir seepage rates were also influential. Curve number, fraction of wetted surface during irrigation, crop coefficients for the end of crop growth and frozen soil conditions, and the non-growing season residue amount were identified as low-sensitivity parameters. Results from the sensitivity analysis were used to prioritize and simplify user interaction with the tool. EDWRD represents the first open-source tool capable of evaluating DWR systems and can be used by multiple user groups to estimate the potential irrigation and water quality benefits of this innovative practice. Keywords: Drainage water recycling, Dual crop coefficient, Open-source model, Sensitivity analysis, Subsurface drainage, Supplemental irrigation.
Applying the FAO-56 Dual Kc Method for Irrigation Water Requirements over Large Areas of the Western U.S.
Authors: Allen Richard G. , Robison Clarence W. , Huntington Justin , Wright James L. , Kilic Ayse 
Published: December 2020

HighlightsThe FAO-56 dual crop coefficient procedure was applied over the entire agricultural areas of Idaho and Nevada to determine evapotranspiration (ET) and net irrigation water requirements (IWR).Basal crop coefficients were expressed as functions of normalized cumulative growing degree days.ET during dormant seasons was included in the estimates.The procedure was applied to a U.S. West-wide study of climate change effects on ET and IWR.Abstract. The FAO-56 dual crop coefficient procedure was used to determine evapotranspiration (ET) and net irrigation water requirements for all agricultural areas of the states of Idaho and Nevada and in a western U.S. study on effects of climate change on future irrigation water requirements. The products of the applications are for use by state governments for water rights management, irrigation system planning and design, wastewater application system design and review, hydrologic water balances, and groundwater modeling. The products have been used by the U.S. federal government for assessing impacts of current and future climate change on irrigation water demands. The procedure was applied to data from more than 200 weather station locations across the state of Idaho, 200 weather station locations across the state of Nevada, and eight major river basins in the western U.S. for available periods of weather records. Estimates were made over daily, monthly, and annual time intervals. Methods from FAO-56 were employed for calculating reference ET and crop coefficients (Kc), with ET calculations performed for all times of the calendar year including winter. Expressing Kc as a function of thermal-time units allowed application across a wide range of local climates and elevations. The ET estimates covered a wide range of agricultural crops grown in the western U.S. plus a number of native plant systems, including wetlands, rangeland, and riparian trees. Evaporation was estimated for three types of open-water surfaces ranging from deep reservoirs to small farm ponds. Keywords: Consumptive use, Dual crop coefficient, Evapotranspiration, FAO-56, Irrigation water requirements.
Control of the intensity distribution along the light spiral generated by a generalized spiral phase plate
Authors: Ustinov Andrey V. , Khonina Svetlana N. , Khorin Pavel A. , Porfirev Alexey P. 
Published: December 2020

This paper proposes a method for shaping a light spiral with the desired intensity and phase distributions based on the addition of an angular-dependent amplitude distribution to the phase transmission function of a generalized spiral phase plate. An expression for the amplitude distribution of the illuminating beam, which provides a given intensity distribution in the focal plane along the light spiral, was derived, with the numerically and experimentally obtained results confirming the analytical calculations. The ability to control the phase and intensity gradient along the generated light curves allows one to shape the desired transverse energy flow distribution in the focal plane, which is important for optical manipulation of nano- and microparticles as demonstrated by the laser guiding of trapped 5 µm polystyrene microspheres.
Cost of a new method of active screening for human African trypanosomiasis in the Democratic Republic of the Congo
Authors: Snijders Rian , Fukinsia Alain , Claeys Yves , Mpanya Alain , Hasker Epco , Meheus Filip , Miaka Erick , Boelaert Marleen 
Published: December 2020

Background
Human African trypanosomiases caused by the Trypanosoma brucei gambiense parasite is a lethal disease targeted for eradication. One of the main disease control strategies is active case-finding through outreach campaigns. In 2014, a new method for active screening was developed with mini, motorcycle-based, teams. This study compares the cost of two active case-finding approaches, namely the traditional mobile teams and mini mobile teams, in the two health districts of the Democratic Republic of the Congo.

Methods
The financial and economic costs of both approaches were estimated from a health care provider perspective. Cost and operational data were collected for 12 months for 1 traditional team and 3 mini teams. The cost per person screened and diagnosed was calculated and univariate sensitivity analysis was conducted to identify the main cost drivers.

Results
During the study period in total 264,630 people were screened, and 23 HAT cases detected. The cost per person screened was lower for a mini team than for a traditional team in the study setting (US$1.86 versus US$2.08). A comparable result was found in a scenario analysis, assuming both teams would operate in a similar setting, with the cost per person screened by a mini team 15% lower than the cost per person screened by a traditional team (1.86 $ vs 2.14$). The main explanations for this lower cost are that mini teams work with fewer human resources, cheaper means of transportation and do not perform the Capillary Tube Centrifugation test or card agglutination test dilutions.

Discussion
Active HAT screening with mini mobile teams has a lower cost and could be a cost-effective alternative for active case-finding. Further research is needed to determine if mini mobile teams have similar or better yields than traditional mobile teams in terms of detections and cases successfully treated.
Chronic kidney disease as a risk factor for peripheral nerve impairment in older adults: A longitudinal analysis of Health, Aging and Body Composition (Health ABC) study
Authors: Doshi Simit , Moorthi Ranjani N. , Fried Linda F. , Sarnak Mark J. , Satterfield Suzanne , Shlipak Michael , Lange-Maia Brittney S. , Newman Anne B. , Strotmeyer Elsa S. 
Published: December 2020

IntroductionSensory and motor nerve deficits are prevalent in older adults and are associated with loss of functional independence. We hypothesize that chronic kidney disease predisposes to worsening sensorimotor nerve function over time.Materials and methodsParticipants were from the Health, Aging and Body Composition Study (N = 1121) with longitudinal data between 2000–01 (initial visit) and 2007–08 (follow-up visit). Only participants with non-impaired nerve function at the initial visit were included. The predictor was presence of CKD (estimated GFR ≤ 60 ml/min/1.73m2) from the 1999–2000 visit. Peripheral nerve function outcomes at 7-year follow-up were 1) Motor: “new” impairments in motor parameters (nerve conduction velocity NCV < 40 m/s or peroneal compound motor action potential < 1 mv) at follow-up, and 2) Sensory: “new” impairment defined as insensitivity to standard 10-g monofilament or light 1.4-g monofilament at the great toe and “worsening” as a change from light to standard touch insensitivity over time. The association between CKD and “new” or “worsening” peripheral nerve impairment was studied using logistic regression.ResultsThe study population was 45.9% male, 34.3% Black and median age 75 y. CKD participants (15.6%) were older, more hypertensive, higher in BMI and had 2.37 (95% CI 1.30–4.34) fold higher adjusted odds of developing new motor nerve impairments in NCV. CKD was associated with a 2.02 (95% CI 1.01–4.03) fold higher odds of worsening monofilament insensitivity. CKD was not associated with development of new monofilament insensitivity.ConclusionsPre-existing CKD leads to new and worsening sensorimotor nerve impairments over a 7-year time period in community-dwelling older adults.
The benefit of adjuvant radiotherapy on overall survival in resected stage I to II pancreatic cancer: A propensity-adjusted analysis
Authors: Lin Zhuang-Bin , Song Jian-Yuan , Li An-Chuan , Chen Cheng , Huang Xiao-Xue , Xu Ben-Hua 
Published: December 2020

Background
The survival time of patients with early pancreatic cancer (PC) is still disappointing, even after surgical resection. PC has an extremely poor prognosis. Herein, we aimed to investigate the survival effect of postoperative radiotherapy (PORT) on resected stage I to II PC.

Material and methods
A large eligible sample of patients was identified from 2010 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) registry. Survival analysis was conducted to evaluate the efficiency of PORT. Propensity score matching (PSM) analysis was used to reduce selection bias and to make the groups comparable.

Results
A total of 3219 patients with resected stage I to II PC was included after rigid screening. The median overall survival (OS) was 26 months with PORT (n = 1055) versus 21 months with non-PORT (n = 2164) before matching (p<0.001). By multivariable analysis, PORT remained a favorable prognostic predictor for OS. In PSM analysis, receiving PORT was associated with improved OS (median, 26 months vs. 23 months; at 2 years, 51.7% vs. 46.7%; at 5 years, 23.3% vs. 17.4% (P = 0.006). After further meticulous exploration, only the stage IIB subgroup benefited from PORT (p<0.001). This result was due to the positive lymph node state (N+), whose mortality risk was cut by 23.4% (p<0.001) by PORT.

Conclusion
Addition of PORT to the treatment of patients with resected stage I to II PC conveys a survival benefit, particularly among those with N-positive or stage IIB disease.
High school students’ use of JUUL pod flavors before and after JUUL implemented voluntary sales restrictions on certain flavors in 2018
Authors: Morean Meghan E. , Bold Krysten W. , Kong Grace , Camenga Deepa R. , Jackson Asti , Simon Patricia , Davis Danielle R. , Krishnan-Sarin Suchitra 
Published: December 2020

Objectives
In November 2018, JUUL, Inc. restricted sales of mango, fruit medley, crème brûlée, and cucumber pods to its website. Physical/online sales of tobacco, menthol, and mint pods continued. We examined rates of adolescent JUUL device and flavored pod use before and after restrictions were implemented to examine their potential impact.

Methods
Students from 4 Connecticut high schools completed cross-sectional surveys in 2018 (N = 3170) and 2019 (N = 3074).

Results
Compared to 2018, current (past-month) JUUL use decreased in 2019 (30.2–25.6%). Among current JUUL users, restricted flavor use (mango [62.8–36.9%]; cucumber [27.7–11.9%]; fruit [23.5–11.4%]; crème brûlée [12.3–5.0%]) and the total number of flavors used (2.09[SD = 1.71]-1.51[SD = 1.33]) decreased (p-values < .001), while mint pod use increased (62.0–68.6%, p < .01). Tobacco and menthol pod use remained stable.

Conclusions
Following voluntary sales restrictions implemented by JUUL, Inc., restricted flavor use and the total number of flavors used decreased among JUUL users while mint use increased. Results suggest flavor restrictions may impact adolescents’ e-cigarette use. While 2020 Food and Drug Administration restrictions on mint pods may further limit youth JUUL use, research is needed to determine where youth acquire restricted flavors and if restrictions prompt increased popularity of unrestricted devices/e-liquids.
Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study
Authors: Thomson Ross J. , Hunter Jennifer , Dutton Jonathan , Schneider James , Khosravi Maryam , Casement Alisha , Dhadwal Kulwant , Martin Daniel 
Published: December 2020

Background
Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there have been few published reports from the United Kingdom (UK). Understanding the characteristics of the affected population admitted to intensive care units (ICUs) in the UK is crucial to inform clinical decision making, research and planning for future waves of infection.

Methods
We conducted a prospective observational cohort study of all patients with COVID-19 admitted to a large UK ICU from March to May 2020 with follow-up to June 2020. Data were collected from health records using a standardised template. We used multivariable logistic regression to analyse the factors associated with ICU survival.

Results
Of the 156 patients included, 112 (72%) were male, 89 (57%) were overweight or obese, 68 (44%) were from ethnic minorities, and 89 (57%) were aged over 60 years of age. 136 (87%) received mechanical ventilation, 77 (57% of those intubated) were placed in the prone position and 95 (70% of those intubated) received neuromuscular blockade. 154 (99%) patients required cardiovascular support and 44 (28%) required renal replacement therapy. Of the 130 patients with completed ICU episodes, 38 (29%) died and 92 (71%) were discharged alive from ICU. In multivariable models, age (OR 1.13 [95% CI 1.07–1.21]), obesity (OR 3.06 [95% CI 1.16–8.74]), lowest P/F ratio on the first day of admission (OR 0.82 [95% CI 0.67–0.98]) and PaCO2 (OR 1.52 [95% CI 1.01–2.39]) were independently associated with ICU death.

Conclusions
Age, obesity and severity of respiratory failure were key determinants of survival in this cohort. Multiorgan failure was prevalent. These findings are important for guiding future research and should be taken into consideration during future healthcare planning in the UK.
Mediating effects of general self-efficacy on the relationship between the source of meaning in life and prosocial behaviours in vocational college nursing students: A cross-sectional study
Authors: Cheng Linan , Ye Yansheng , Zhong Zhaoyang , Zhang Fengying , Hu Xiuying , Cui Renshan , Chen Qian 
Published: December 2020

Objectives
To examine the mediating effect of general self-efficacy on the relationship between the source of meaning in life (SML) and prosocial behaviours in vocational college nursing students.

Methods
Between March and June 2019, a cross-sectional descriptive study was conducted, and 799 nursing students from three vocational colleges completed the Source of Meaning in Life Scale, General Self-Efficacy Scale and Prosocial Behaviours Scale. Data were analyzed using structural equation modelling and statistical analysis by SPSS (version 23.0, IBM).

Results
The average SML, general self-efficacy and prosocial behaviours scores of the 799 nursing students were 6.43±0.83, 2.48±0.59 and 3.69±0.62, respectively. Correlation analysis showed that SML, general self-efficacy and prosocial behaviours were positively correlated (P<0.01). General self-efficacy partially mediated the relationship between SML and prosocial behaviours (P<0.01); this mediating effect contributed 22.97% of the total effect and explained 17.6% of the variance in the dependent variable.

Conclusions
Educators should focus on cultivating nursing students’ cognition and experience of meaning in life and their efficacy in life, study and work, which can improve students’ “people-oriented” service and prosocial behaviour and the quality of nursing services.