bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin Treatment Combined with TGF-β Silencing Inhibits Epithelial- Mesenchymal Transition in CF41 Canine Mammary Cancer Cell Line
Authors: Custódio Paulo R. , Colombo Jucimara , Ventura Fabrício V. , Castro Tialfi B. , Zuccari Debora A.P.C. 
Published: April 2020

Background:Mammary cancer is the most prevalent type of cancer in female dogs. The main cause of mortality is the occurrence of metastasis. The metastatic process is complex and involves the Epithelial- Mesenchymal Transition (EMT), which can be activated by Transforming Growth Factor beta (TGF-β) and involves changes in cellular phenotype, as well as, in the expression of proteins such as E-cadherin, N-cadherin, vimentin and claudin-7. Melatonin is a hormone with oncostatic and anti-metastatic properties and appears to participate in the TGF-β pathway. Thus, the present work aimed to evaluate the expression of EMT markers, E-cadherin, N-cadherin, vimentin and claudin-7, as well as, the cell migration of the canine mammary cancer cell line, CF41, after treatment with melatonin and TGF-β silencing.Methods:Canine mammary cancer cell line, CF41, was cultured and characterized in relation to markers ER, PR and HER2. Cell line CF41 with reducing expression level of TGF-βwas performed according to Leonel et al. (2017). Expression of the protein E-caderin, N-cadherin, vimentin and claudin-7 was evaluated by immunocytochemistry and quantified by optical densitometry. The analysis of cell migration was performed in transwell chambers with 8μM pore size membrane.Results:CF41 cells present a triple negative phenotype, which is an aggressive phenotype. Immunocytochemistry staining showed increased expression of E-caderin and claudin-7 (P˂0.05) and decreased expression of N-cadherin and vimentin (P˂0.05) in CF41 cells after treatment with 1mM melatonin and TGF-β silencing. Moreover, treatment with melatonin and TGF-β silencing was able to reduce migration in cell line CF41 (P˂0.05).Conclusion:Our data suggests that therapies combining TGF- β1 silencing and melatonin may be effective in suppressing the process of EMT, corroborating the hypothesis that melatonin acts on the TGF-β1 pathway and can reduce the metastatic potential of CF41 cells. This is so far the first study that reports melatonin treatment in CF41 cells with TGF-β1 silencing and its effect on EMT. Thus, further studies are needed to confirm this hypothesis.
DEVELOPING PMRI LEARNING ENVIRONMENT THROUGH LESSON STUDY FOR PRE-SERVICE PRIMARY SCHOOL TEACHER
Authors: Fauziah Anna , Putri Ratu Ilma Indra , Zulkardi Zulkardi , Somakim Somakim 
Published: April 2020

Teachers’ pedagogical ability contributes significantly to their process and learning performance. To improve it, a development process is needed as long as they are still having their process of education or they are still teacher students. This study aimed to develop a valid and practical PMRI learning environment through lesson study which had a potential effect on improving the pedagogical abilities of pre-service primary school teachers. A design research method of development study type was used in this study consisting of three phases, namely the preliminary, development or prototyping phase, and assessment phase. The research subjects were 32 students of Primary School Teacher Education of Sriwijaya University. The data were collected using walkthrough, observation, documentation, questionnaires, interviews, and tests. The study produced a learning environment with a valid and practical Campus-School (CS) model and had a potential effect on improving teacher students' pedagogical ability. The learning environment was in the form of training on campus and implementation in schools. Based on the data analysis, the learning environment was able to produce pre-service primary education teachers understanding the PMRI through lesson study and design PMRI learning tools through a lesson study.
Konsep Negara Ideal Ali Abdul Raziq Dan Relevansinya Dengan Pancasila
Authors: Putra Ridho 
Published: April 2020

Negara yang ideal pada hakikatnya adalah suatu keluarga, sehingga dalam suatu negara semua bersaudara. Karenanya setiap warga negara haruslah bersikap kekeluargaan yang mencerminkan adanya kerukukunan dan keharmonisan, baik di kalangan elite pemerintahan maupun rakyatnya. Mirisnya, Negara telah dijadikan alat untuk memuaskan keinginan bagi para penguasa. Yang menjadi fokus permasalahan dalam penelitian ini yaitu bagaimana bentuk negara ideal menurut Ali Abdul Raziq? Dan apa relevansi negara ideal Ali Abdul Raziq terhadap pancasila di Indonesia?Tulisan ini adalah hasil studi pustaka. Penelitian ini dianalisis dengan menggunakan metode deskriptif analitis dan penalaran deduktif. Negara ideal menurut Ali Abdul Raziq ialah negara yang berasaskan humanisme universal yang memperjuang-kan rakyatnya, demokrasi dan keadilan sosial, yaitu negara sekuler bagi kaum muslimin dan non muslim yang hidup di negara itu. Sementara relevansi pemikiran negara ideal Ali Abdul Raziq dengan Pancasila adalah jika nilai-nilai demokrasi, keadilan sosial berasaskan humanisme yang harus diberikan kepada setiap manusia tanpa memandang label agamanya, maka negara ideal yang dimaksud Ali Abdul Raziq relevan dengan filosofi Pancasila sebagai dasar negara Indonesia. Indonesia bukan negara sekuler dan juga bukan negara agama, tetapi berada di tengah-tengah, yaitu nilai-nilai agama diintegrasikan ke dalam hukum negara.
Análise da Variação Microclimática em Diferentes Níveis de Fragmentação (Analysis of Microclimate Variation at Different Levels of Fragmentation)
Authors: Freitas Anne Falcão de , Santos Joel Silva dos , Lima Rita Baltazar de 
Published: April 2020

A fragmentação da vegetação inserida no ambiente urbano, decorrente da ocupação desordenada do solo, gera transformações significativas na dinâmica dos fatores termodinâmicos. Este trabalho analisa o sistema microclimático urbano, subsistema termodinâmico da Universidade Federal da Paraíba, em diferentes níveis de fragmentação. Foram realizadas coletas de dados de temperatura e umidade relativa do ar, em três pontos com diferentes fragmentações, durante os períodos: chuvoso (março a agosto) e seco (setembro a fevereiro). Também foi avaliado o nível de estresse térmico e foi efetuada a classificação dos tipos de cobertura de solo em cada ponto monitorado, resultando em nove classes, de acordo com a percentagem da presença de vegetação, de materiais permeáveis e de materiais impermeáveis, tendo sido utilizados métodos quantitativos e qualitativos. Os resultados demonstraram que os diferentes níveis de fragmentação da Mata Atlântica, no espaço urbano da UFPB, têm alterado o campo térmico, e consequentemente alterado também o conforto térmico desse espaço. A B S T R A C T The fragmentation of vegetation inserted in the urban environment, resulting from the disorderly occupation of soil, generates significant transformation in the dynamics of the thermodynamic factors. This paper analyzes the urban microclimate system, thermodynamic subsystem at the Federal University of Paraiba, in different levels of fragmentation. Temperature data collection and relative humidity were held at three points with different fragmentation during periods: rainy (March to August) and dry (September to February). It also assessed the level of thermal stress and it was performed the classification of the soil cover types at each point monitored, resulting in nine classes, according to the percentage of the presence of vegetation, for permeable materials and impervious materials, having been used quantitative and qualitative methods. The results demonstrated that the different levels of fragmentation of the Atlantic Forest, in the urban space from UFPB, have changed the thermal field, and consequently also changed the thermal comfort of this space. Keywords: Microclimate, fragmentation levels, UFPB
Identificação de Ilhas de Calor na Cidade de Campina Grande-PB Utilizando Sensoriamento Remoto (Identification of Heat Islands in Campina Grande City-PB Using Remote Sensing)
Authors: Araújo Elânia Daniele Silva 
Published: April 2020

A intensa urbanização causa diversos problemas de natureza ambiental, climática e social. O crescimento não planejado da população urbana e a remoção da vegetação são fatores que intensificam estes problemas. As temperaturas na cidade são significativamente mais quentes do que as suas zonas rurais circundantes devido às atividades humanas. As intensas mudanças espaciais em áreas urbanas, promovem significativo aumento na temperatura, causando o chamado efeito de Ilha de Calor Urbano (ICU). Campina Grande é uma cidade de tamanho médio que experimentou um crescimento desordenado, desde o tempo do comércio de algodão e, como qualquer cidade de grande ou médio porte, sofre alterações em seu espaço. Dessa forma, este estudo teve por objetivo analisar a variabilidade espaço-temporal da temperatura da superfície (Ts) e detectar ICU, através de técnicas de sensoriamento remoto. Para o efeito, foram utilizadas imagens dos satélites Landsat 5 e 8, dos anos de 1995, 2007 e 2014. Aumentos da Ts foram bem evidentes e foram detectadas duas ICU. Campina Grande mostra um padrão de tendência: o crescimento urbano não planejado é responsável por mudanças no ambiente físico e na forma e estrutura espacial da cidade, o que se reflete sobre o microclima e, em última análise, na qualidade de vida das pessoas. ABSTRACT The intense urbanization causes several problems of environmental, climate and social nature. The unplanned growth of urban population and the vegetation removal are factors that deepen these problems. Temperatures in the city are significantly warmer than its surrounding rural areas due to human activities. Large spatial changes in urban areas promote significant increase in temperature, causing the so-called Urban Heat Island effect (UHI). Campina Grande is a medium-sized town that experienced an uncontrolled growth since the time of the cotton trade and like any large or medium-sized city, undergoes changes in its space. Therefore, this study aimed to analyze surface temperature spatial and temporal variability and to detect potential UHI, through remote sensing techniques. Spectral images from Landsat 5 and 8 satellites were used. Using images from years 1995, 2007 and 2014, considerable increases in temperature were identified and two UHI were recognize. Campina Grande shows a trend pattern: the urban unplanned growth is responsible for changes in the physical environment and in the form and spatial structure of the city, reflecting on people quality of life. Keywords: change detection, surface temperature, heat islands, urbanization.
Análise das relações entre o δ18O do testemunho de gelo do Nevado Illimani (Bolívia) com a precipitação da região tropical da América do Sul (1929-1998) (Analysis of relations between δ18O the ice core of Nevado Illimani (Bolivia) with the ...)
Authors: Peres Tainã Costa 
Published: April 2020

O trabalho explora as relações espaço-temporal entre a série da razão isotópica do oxigênio dezoito (δ18O) do testemunho de gelo do Nevado Illimani (Bolívia) e a série da precipitação na região tropical da América do Sul, entre o período de 1929-1998. Com intuito, de melhorar a representatividade estatística da reconstrução da precipitação pretérita nessa região, usando o δ18O. Foram utilizados dados do δ18O dos primeiros 50 m deste testemunho e 37 séries da precipitação observadas no Brasil e na Bolívia. Adicionalmente, as médias mensais da precipitação foram calculadas e subtraídas das amostras, gerando as anomalias. A análise de dependência abrange as seguintes etapas: elaboração dos diagramas de dispersão, identificação das equações matemáticas de regressão, mensuração do erro e mensuração do índice de correlação. Ao comparar o δ18O com a precipitação identificou-se que os maiores índices de correlação são de aproximadamente |0,2|, o que impossibilita a reconstrução paleoclimática da precipitação pretérita a partir de uma regressão linear. Entretanto, as relações entre as variáveis evidenciam que os registros de máximo (mínimo) fracionamento isotópico estão relacionados à seca (chuvas acima da média) na Amazônia e Centro-Oeste brasileiro e que os registros do δ18O mínimo (máximo) ocorrem simultaneamente secas (chuvas acima da média) nordeste brasileiro, Minas Gerais, Roraima e Amazonas. A B S T R A C T This paper examines the space-temporal relations between a time serie oxygen stable isotopes ratio (δ18O), obtained from an ice core in Nevado Illimani (Bolivia), and the precipitation serie in South America Tropical, the period 1929-1998. For the purpose of upgrade the statistical representativity of the reconstruction of the preterit precipitation in a tropical region, using the δ18O. We used δ18O data from the upper 50 m of this core and 37 precipitation series was collected in Brazil and Bolivia. Additionally, the time series of precipitations were calculated by subtracting of the mean monthly of original series, resulting in anomalies. The dependency analysis has four stages: elaboration of scatter diagrams, identification of mathematical regression equations, error measurement and measurement of the correlation coefficient. By comparing the δ18O with precipitation was identified that the correlation indices larger are about | 0.2 |, so it is impossible makes the paleoclimatic reconstruction from a linear regression used the δ18O. However, relations between the variables show that the δ18O maximum (minimum) are related to dry (rain above the mean) in Amazon and Central Brazil and rain above the mean (dry) in northeast Brazil, Minas Gerais, Amazonas and Roraima. Keywords: glacier tropical, paleoclimatic reconstruction, hydrologic cycle.
Pengaruh Pengendalian Internal dan Komitmen Organisasi Terhadap Kualitas Pelaporan Keuangan (Survei pada Perusahaan Tekstil di Kota Bandung dan Sekitarnya
Authors: Rinie Rinie , Pranata Vincent Mak , Rapina Rapina 
Published: April 2020

Merupakan sebuah fakta bahwa masih terdapat banyak masalah mengenai kualitas pelaporan keuangan pemerintah yang buruk. Hal ini diindikasikan oleh masalah-masalah yang ada pada manajemen keuangan yang disebabkan oleh lemahnya pengendalian internal dan ketidakpatuhan terhadap hukum dan peraturan yang berlaku. Masalah ini menjadi menarik untuk diteliti karena merupakan hal yang sering terjadi di Indonesia. Tujuan dari penelitian ini yaitu untuk menguji pengaruh dari pengendalian internal dan komitmen organisasi terhadap kualitas pelaporan keuangan. Populasi dalam penelitian ini adalah stafaccounting atau finance di perusahaan yang berada di wilayah Bandung dan sekitarnya dengan menggunakan jenis penelitian explanatory. Teknik pengambilan sampel pada penelitian ini menggunakan non probablity sampling dengan prosedur purposive sampling, sampel dari penelitian ini adalah seluruh staf bagian accounting atau finance di PT X dan PT Gistex Textile Division. Data yang telah didapatkan kemudian diproses dengan menggunakan bantuanperangkat lunakSPSS 20. Penelitian ini menggunakan model analisis regresi linier berganda untuk menguji pengaruh dari pengendalian internal dan komitmen organisasi terhadap kualitas pelaporan keuangan. Hasil penelitian ini menunjukkan bahwa pengendalian internal berpengaruh signifikan terhadap kualitas pelaporan keuangan, sementara komitmen organisasi tidak berpengaruh signifikan terhadap kualitas pelaporan keuangan.
Kata kunci: Pengendalian Internal, Komitmen Organisasi, Kualitas Pelaporan Keuangan.
Book Publishing: A Buttress of Stalinism in Russia?
Authors: Mikhailov Valentin 
Published: April 2020

Abstract
In today’s Russia, there is a constant clash of opinions when it comes to perceptions of the past, and to what can be learned from Russia’s Soviet experience in general and Stalinist repression in particular. A consensus which seemed just over the horizon between 1998 and 1991 now grows ever more distant. Nearly half of those surveyed in 2017 say that Stalin should not be seen as a state criminal; that the repressions are best discussed less rather than more, and that there is nothing to be gained by dredging up the past. The only way for Russia to pursue a future of democracy and respect for human rights is to leave all of that baggage behind. How has this come to be? What are the roots of these myths of a great and just Stalin that now emerge 65 years after his death? A series of scholars posit that the key lies in Russian society itself, with its tendency towards being ruled with a firm hand and a state that merely takes a neutral position between the liberals and the Stalinists. Others assert that these are successful constructs of the Kremlin, which seeks to inculcate domestic support for authoritarian rule. In order to resolve this disagreement, we studied the book market for Stalin-related literature published within the last twenty years. The study indicates that the market comprises two mostly separate areas: books by Stalin apologists on the one hand, and books by professional historians and recollections by victims of repressions on the other. Quantitative analysis shows that the former receive markedly greater support, which reflects the state’s role over the past fifteen years in forming a positive image of Stalin.
Perancangan Sistem Informasi Akuntansi Penerimaan Kas Pada CV Bintang Alpro Jakarta
Authors: Kusumadiarti Rini Suwartika , Andriany Ade 
Published: April 2020

Abstact— Accounting for Cash Receipts is a record that is made to carry out cash receipts and cash sales activities or from receivables that are ready and free to use for general company activities. CV. Bintang Alpro Jakarta is a company engaged in the field of Office Stationery Provider Services. In the data processing system CV. Bintang Alpro is still lacking and encountered several obstacles, namely: The process of recording cash receipts is less efficient, cash receipts data are easily lost and making reports that still use manual systems that are less accurate so that the need for cash receipts systems that are more effective and efficient in the form of applications. Data collection methods used in this study are direct observation to the place of research, interviews and literature review. Based on this the results of the research carried out is preceded by an analysis of the process of the running system and then look for problems that occur and designed a desktop-based cash receipts application. Some suggestions for solving these problems include: Developing the system further, and doing system maintenance regularly. Keywords — System Information, Cash Receipt Disbursement. Abstrak—Akuntansi Penerimaan Kas adalah suatu catatan yang dibuat untuk melaksanakan kegiatan penerimaan uang dan penjualan tunai atau dari piutang yang siap dan bebas digunakan untuk kegiatan umum perusahaan Pada sebuah perusahaan hal ini dianggap penting untuk keberlangsungan kegiatan perusahaaan. CV. Bintang Alpro Jakarta merupakan perusahaan yang bergerak dalam bidang Jasa Penyedia Alat Tulis Kantor . Dalam sistem pengolahan datanya CV. Bintang Alpro masih terbilang kurang dan menemui beberapa kendala, yaitu : Proses pencatatan penerimaan kas datanya kurang efisien, data penerimaan kas mudah hilang dan pembuatan laporan yang masih menggunakan sistem manual yang kurang akurat sehingga diperlukannya sistem penerimaan kas yang lebih efektif dan efisien dalam bentuk aplikasi. Metode pengumpulan data yang digunakan dalam penelitian ini adalah dengan melakukan observasi langsung ketempat penelitian, wawancara dan kajian pustaka. Berdasarkan hal tersebut hasil penelitian yang dilakukan adalah diawali dengan analisis proses dari sistem yang berjalan kemudian dicari permasalahan yang terjadi dan dirancanglah aplikasi Penerimaan kas berbasis dekstop. Beberapa saran untuk menyelesaikan permasalahan tersebut, diantaranya :Mengembangkan sistem lebih lanjut,dan dilakukannya perawatan sistem secara berkala. Kata Kunci — Sistem Informasi, Penerimaan Kas
CRIMINALISTIC METHODICS IN THE SYSTEM OF CRIMINALISTIC THEORY
Authors: Terehovich V. , Nimande T. 
Published: April 2020

The term “criminal investigation technique” has two meanings in the scope of Theory of Criminalistics. The first meaning of the term is used for disclosure of one of regulatory means in Criminalistics cognition - criminal investigation technique cognition. This meaning of Criminalistics technique is disclosing in the limits of structure of the process of Criminalistics cognition. The second meaning of the term “Criminalistics technique” is disclosing in the limits of description of the system of cognitive activity in the sphere of applying criminal law.
During disclosure of the second meaning of the term “Criminalistics technique” we are pointing out that, first of all, it is the system of knowledge, used for organization of investigation of the event of criminal offense, id est, knowledge necessary and sufficient for getting new knowledge about the event of criminal offense. Knowledge acquired and used during applying criminal law in Latvia is knowledge of substantiate but not of faith nature. This knowledge is collective (sociable) knowledge and manifests itself during rationalization of investigation of the event of criminal offense. Personal knowledge manifests itself only during the stage of optimization of investigation of the event of criminal offense.
It is necessary to differentiate knowledge about criminal offense as knowledge about theoretical construction in criminal law and knowledge about the event of criminal offense as knowledge about phenomenon of fragment of material reality, which is evaluated as criminal offence. Knowledge about criminal offense (about corpus delicti) and linked circumstances as theoretical constructions in criminal law is collective (common, social) knowledge. This knowledge is gained by the person investigating the event of the criminal act in the course of long legal education. Knowledge about the event of criminal offense is got during another cognition activity
- investigation (cognition) of specific event of criminal offense. This knowledge is domain for other people, id est, collective (common, social) knowledge and it is fixed in the materials of criminal case.
Theoretical knowledge, necessary for reasonable process of investigation of the event of criminal offense, encloses two types of knowledge (primary and guiding) about rationalization of the activity. Criminalistics techniques (system of knowledge about organization of Criminalistics activity) as subbranch of Criminalistics theory is fulfilling methodological function for developing of techniques for organization of investigation of separate types of criminal offenses.
Keywords: Criminalistics theory, criminalistics techniques, organization of investigation of the event of criminal offense.
Characterization of Impacts of Elastic-plastic Spheres
Authors: Szabó Bence , Kossa Attila 
Published: April 2020

This work presents explicit dynamic finite element simulations of various impacts of elastic-plastic solid spheres with flat walls. Different analytical models describing the mechanics of the impact phenomenon are also presented. Elastic and elastic-plastic material models for the sphere and the wall are considered during the analyses. The applicability of these different models is demonstrated and their accuracies are investigated. Closed-form analytical functions are proposed to describe the relationship between the initial velocity of the sphere and the investigated contact characteristics for the given material models. Analysis is carried out to study the effect of the friction coefficient as well as the angle of impact for various cases.