bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restructuring ENT out-patient services during the coronavirus disease 2019 pandemic – an iterative approach
Authors: Halliwell-Ewen M , Atkin B , Huins C T , Dalton C L 
Published: July 2020

AbstractBackgroundCoronavirus disease 2019 has demanded enormous adjustments to National Health Service provisions. Non-urgent out-patient work was initially postponed or performed virtually, but is now being re-established. In ENT surgery, aerosol-generating procedures pose a particular challenge in out-patient settings.ObjectiveA rapid restructuring of ENT out-patient services is required, to safely accommodate aerosol-generating procedures and increase in-person attendances, whilst coronavirus disease 2019 persists.MethodsData were collected prospectively over four consecutive cycles. Two surveys were conducted. Results were analysed and disseminated, with recommendations for service restructuring implemented at cycle end-points.ResultsOut-patient activity increased four-fold, associated with a significant rise in aerosol-generating procedures during the study period. Mean aerosol-generating procedure duration dropped weekly, implying a learning curve. Service restructuring occurred at cycle end-points.ConclusionIterative data gathering, results analysis and outcome dissemination enabled a swift, data-driven approach to the restructuring of ENT out-patient services. Patient and staff safety was ensured, whilst out-patient capacity was optimised.
Cercarial swimming performance and its potential role as a key variable of trematode transmission
Authors: Morley Neil J. 
Published: July 2020

AbstractTrematode transmission in aquatic habitats from molluscan intermediate host to vertebrate or invertebrate target host is typically undertaken by a free-living stage known as cercariae. Active locomotion by cercariae is a key aspect of the transmission process with the swimming speed potentially contributing to infection success. Individual cercarial species swim at different speeds but the significance of this to infection potential has not been determined. This study, using data from the scientific literature, investigates the role of swimming speed in relation to cercarial morphology, host-searching strategies and target host species. Larger cercariae swim faster than smaller ones with tail length being the principal factor controlling locomotion rates. Different cercarial morphotypes swim at different speeds, in particular, furcocercariae, with the exception of the schistosomes, being faster swimmers than mono-tailed cercariae. Host-searching behaviour has a significant influence on swimming speeds with ‘active-searching’ strategies swimming slower than those adopting ‘active-waiting’ or ‘prey mimcry’ strategies. Vertebrate-infecting cercariae swim faster than those infecting invertebrates with species targeting fish demonstrating the highest locomotion rates and those targeting arthropods the slowest speeds. The adaptions of individual cercarial swimming speeds to biological variables and their interactions with the physical processes of aquatic habitats are discussed.
Delayed Bilateral Teleoperation of the Speed and Turn Angle of a Bipedal Robot
Authors: Moya Viviana , Slawiñski Emanuel , Mut Vicente 
Published: July 2020

SUMMARYThis paper proposes a shared control scheme which aims to achieve a stable control of the speed and turn of a bipedal robot during a delayed bilateral teleoperation. The strategy allows to get a delay-dependent damping value that must be injected to assure a bounded response of the hybrid system, while simultaneously, the human operator receives a force feedback that help him to decrease the synchronism error. Furthermore, a test where a human operator handles the walking of a simulated bipedal robot, to follow a curve path in front of varying time delay, is performed and analyzed.
Use of 911 for Rapid Re-Triage of Critical Trauma Patients
Authors: Toy Jake , Kazan Clayton , Gausche-Hill Marianne , Bosson Nichole 
Published: July 2020

AbstractObjectives:The objective of this study was to evaluate the effectiveness of a 911 trauma re-triage protocol implemented at a new community hospital in a region with a high volume of trauma and frequent transports by private vehicle.Methods:This retrospective cohort study included all trauma patients ≥15 years old transferred via 911 trauma re-triage from a new community hospital over a 10-month period from August 2015 through April 2016. Criteria for 911 trauma re-triage were developed with input from local Emergency Medical Services (EMS) and trauma experts. An educational module, along with the criteria and implementation steps, was distributed to the emergency department (ED) personnel at the community hospital. Data were abstracted from the regional trauma registry, and the EMS patient care records were reviewed. Primary outcomes were: (1) median total transport time; and (2) proportion of patients who met the 911 re-triage criteria.Results:During the study period, 32 patients with traumatic injuries were transferred via 911 re-triage to the closest trauma center (TC). The median age of patients was 31 years (IQR 24-45 years) with 78% male and 66% suffering from a penetrating mechanism. The median prehospital provider scene time was 10 minutes (IQR 8-12 minutes) and transport time was seven minutes (IQR 6-9 minutes). Median total transport time was 17 minutes (IQR 15-20 minutes). Seventeen patients (53%) met 911 re-triage criteria as determined by study investigators. The most common criteria met was “penetrating injury to the head, neck, or torso” in 14 cases.Conclusion:This study demonstrated that 911 re-triage was a feasible strategy to expeditiously transfer critical trauma patients to a TC within a mature trauma system in an urban-suburban setting with a median total transport time of 17 minutes.
Coping with negative shocks and the role of the farm input subsidy programme in rural Malawi
Authors: Ajefu Joseph B. , Efobi Uchenna , Beecroft Ibukun 
Published: July 2020

AbstractThis study uses household panel data from Malawi's 2010/11 and 2012/13 Integrated Household Panel Survey to investigate the mitigating role of its Farm Input Subsidy Programme (FISP) against the deleterious impacts of negative rainfall shock on households’ welfare in rural Malawi. The study finds that the FISP has a cushioning role on the negative impact of rainfall shocks. The use of a farm input subsidy scheme enables rural households to substantially increase their food consumption and overall food security, despite the increasing threat of climate change. The results of this study highlight the importance of agricultural policy, such as the FISP, in rural households’ mitigation of weather risk.
Democratic altruism
Authors: Tanasoca Ana , Dryzek John S. 
Published: July 2020

AbstractTransnational altruism comes in many forms, prominently among them private giving through charitable NGOs. This paper focuses on the altruistic actions of those giving to charitable organizations and especially on the subsequent altruistic choices of those second-order, donor-organizations. Leaving choices about how donated money should be used exclusively in the hands of donors is morally problematic in various ways. This is why transnational relationships that involve private giving from rich to poor should be democratized. We propose thus a new moral principle for guiding altruistic behavior: democratic altruism. We develop our argument by focusing on the moral powers and formative agency that donors exercise through their charitable behavior, in particular through their choice to support particular types of aid or organizations. We argue that if and when donors give, they should do so in a way that allows the poor to exercise formative agency as well, in decisions over how donated resources should be used on the ground.
Characteristics of Future Warmer Base States in CESM2
Authors: Meehl Gerald A. , Arblaster Julie M. , Bates Susan , Richter Jadwiga H. , Tebaldi Claudia , Gettelman Andrew , Medeiros Brian , Bacmeister Julio , DeRepentigny Patricia , Rosenbloom Nan , Shields Christine , Hu Aixue , Teng Haiyan , Mills Michael J. , Strand Gary 
Published: July 2020

AbstractSimulations of 21st century climate with Community Earth System Model version 2 (CESM2) using the standard atmosphere (CAM6), denoted CESM2(CAM6), and the latest generation of the Whole Atmosphere Community Climate Model (WACCM6), denoted CESM2(WACCM6), are presented, and a survey of general results is described. The equilibrium climate sensitivity (ECS) of CESM2(CAM6) is 5.3°C, and CESM2(WACCM6) is 4.8°C, while the transient climate response (TCR) is 2.1°C in CESM2(CAM6) and 2.0°C in CESM2(WACCM6). Thus, these two CESM2 model versions have higher values of ECS than the previous generation of model, the CESM (CAM5) (hereafter CESM1), that had an ECS of 4.1°C, though the CESM2 versions have lower values of TCR compared to the CESM1 with a somewhat higher value of 2.3°C. All model versions produce credible simulations of the time evolution of historical global surface temperature. The higher ECS values for the CESM2 versions are reflected in higher values of global surface temperature increase by 2,100 in CESM2(CAM6) and CESM2(WACCM6) compared to CESM1 between comparable emission scenarios for the high forcing scenario. Future warming among CESM2 model versions and scenarios diverges around 2050. The larger values of TCR and ECS in CESM2(CAM6) compared to CESM1 are manifested by greater warming in the tropics. Associated with a higher climate sensitivity, for CESM2(CAM6) the first instance of an ice‐free Arctic in September occurs for all scenarios and ensemble members in the 2030–2050 time frame, but about a decade later in CESM2(WACCM6), occurring around 2040–2060.
Saturn's Nightside Dynamics During Cassini's F Ring and Proximal Orbits: Response to Solar Wind and Planetary Period Oscillation Modulations
Authors: Bradley T. J. , Cowley S. W. H. , Bunce E. J. , Melin H. , Provan G. , Nichols J. D. , Dougherty M. K. , Roussos E. , Krupp N. , Tao C. , Lamy L. , Pryor W. R. , Hunt G. J. 
Published: July 2020

AbstractWe examine the final 44 orbits of the Cassini spacecraft traversing the midnight sector of Saturn's magnetosphere to distances of ~21 Saturn radii, to investigate responses to heliospheric conditions inferred from model solar wind and Cassini galactic cosmic ray flux data. Clear storm responses to anticipated magnetospheric compressions are observed in magnetic field and energetic particle data, together with Saturn kilometric radiation (SKR), auroral hiss, and ultraviolet auroral emissions. Most compression events are associated with corotating interaction regions, producing ~2–3.5 day intervals of magnetospheric activity that are recurrent with the ~26 day solar rotation period (one or two such events per rotation), though one on the final pass is related to a nonrecurrent interplanetary shock possibly associated with an earlier X‐class solar flare. The response to compressions is modulated by the concurrent relative phasing of the northern and southern planetary period oscillation (PPO) systems, with long (>1 planetary rotation) SKR low‐frequency extension (LFE) intervals associated with strong field‐aligned coupling currents being favored when the two PPO systems act together to thin and thicken the tail plasma sheet during each PPO cycle. LFE onsets/intensifications are then favored at thin plasma sheet phases most unstable to reconnection, producing energetic nightside particle injections and poleward contractions of dawn‐brightened auroras. Correspondingly, solar rotation recurrent intervals of magnetospheric quiet conditions also occur with weak energetic particle fluxes and auroral emissions, associated with extended solar wind rarefactions. Overall, the results emphasize how strongly activity in Saturn's magnetosphere is modulated by concurrent heliospheric conditions.
Analysis of compositions of microbiomes with bias correction
Authors: Lin Huang , Peddada Shyamal Das 
Published: July 2020

AbstractDifferential abundance (DA) analysis of microbiome data continues to be a challenging problem due to the complexity of the data. In this article we define the notion of “sampling fraction” and demonstrate a major hurdle in performing DA analysis of microbiome data is the bias introduced by differences in the sampling fractions across samples. We introduce a methodology called Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC), which estimates the unknown sampling fractions and corrects the bias induced by their differences among samples. The absolute abundance data are modeled using a linear regression framework. This formulation makes a fundamental advancement in the field because, unlike the existing methods, it (a) provides statistically valid test with appropriate p-values, (b) provides confidence intervals for differential abundance of each taxon, (c) controls the False Discovery Rate (FDR), (d) maintains adequate power, and (e) is computationally simple to implement.
IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
Authors: Bisi Sara , Marchesi Stefano , Rizvi Abrar , Carra Davide , Beznoussenko Galina V. , Ferrara Ines , Deflorian Gianluca , Mironov Alexander , Bertalot Giovanni , Pisati Federica , Oldani Amanda , Cattaneo Angela , Saberamoli Ghazaleh , Pece Salvatore , Viale Giuseppe , Bachi Angela , Tripodo Claudio , Scita Giorgio , Disanza Andrea 
Published: July 2020

AbstractIt is unclear whether the establishment of apical–basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and podocalyxin. Molecularly, IRSp53 acts by regulating the localization and activity of the small GTPase RAB35, and by interacting with the actin capping protein EPS8. Using correlative light and electron microscopy, we further show that IRSp53 ensures the shape and continuity of the opposing plasma membrane of two daughter cells, leading to the formation of a single apical lumen. Genetic removal of IRSp53 results in abnormal renal tubulogenesis, with altered tubular polarity and architectural organization. Thus, IRSp53 acts as a membrane curvature-sensing platform for the assembly of multi-protein complexes that control the trafficking of apical determinants and the integrity of the luminal plasma membrane.
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Authors: Luthria Gaurav , Li Ran , Wang Stephanie , Prytyskach Mark , Kohler Rainer H. , Lauffenburger Douglas A. , Mitchison Timothy J. , Weissleder Ralph , Miller Miles A. 
Published: July 2020

AbstractMicrotubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quantify MT dynamics in live xenograft tumor models. Among analyzed features, cancer cells in vivo displayed higher coherent orientation of MT dynamics along their cell major axes compared with 2D in vitro cultures, and distinct from 3D collagen gel cultures. This in vivo MT phenotype was reproduced in vitro when cells were co-cultured with IL4-polarized MΦ. MΦ depletion, MT disruption, targeted kinase inhibition, and altered MΦ polarization via IL10R blockade all reduced MT coherence and/or tumor cell elongation. We show that MT coherence is a defining feature for in vivo tumor cell dynamics and migration, modulated by local signaling from pro-tumor macrophages.
Oculomotor inhibition precedes temporally expected auditory targets
Authors: Abeles Dekel , Amit Roy , Tal-Perry Noam , Carrasco Marisa , Yuval-Greenberg Shlomit 
Published: July 2020

AbstractEye movements are inhibited prior to the onset of temporally-predictable visual targets. This oculomotor inhibition effect could be considered a marker for the formation of temporal expectations and the allocation of temporal attention in the visual domain. Here we show that eye movements are also inhibited before predictable auditory targets. In two experiments, we manipulate the period between a cue and an auditory target to be either predictable or unpredictable. The findings show that although there is no perceptual gain from avoiding gaze-shifts in this procedure, saccades and blinks are inhibited prior to predictable relative to unpredictable auditory targets. These findings show that oculomotor inhibition occurs prior to auditory targets. This link between auditory expectation and oculomotor behavior reveals a multimodal perception action coupling, which has a central role in temporal expectations.
Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
Authors: Deniz Özgen , Ahmed Mamataz , Todd Christopher D. , Rio-Machin Ana , Dawson Mark A. , Branco Miguel R. 
Published: July 2020

AbstractAcute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of transcriptional regulators are transposable elements (TEs), whose aberrant usage could contribute to oncogenic transcriptional circuits. However, the regulatory influence of TEs and their links to AML pathogenesis remain unexplored. Here we identify six endogenous retrovirus (ERV) families with AML-associated enhancer chromatin signatures that are enriched in binding of key regulators of hematopoiesis and AML pathogenesis. Using both locus-specific genetic editing and simultaneous epigenetic silencing of multiple ERVs, we demonstrate that ERV deregulation directly alters the expression of adjacent genes in AML. Strikingly, deletion or epigenetic silencing of an ERV-derived enhancer suppresses cell growth by inducing apoptosis in leukemia cell lines. This work reveals that ERVs are a previously unappreciated source of AML enhancers that may be exploited by cancer cells to help drive tumour heterogeneity and evolution.
Operando time-resolved X-ray absorption spectroscopy reveals the chemical nature enabling highly selective CO2 reduction
Authors: Lin Sheng-Chih , Chang Chun-Chih , Chiu Shih-Yun , Pai Hsiao-Tien , Liao Tzu-Yu , Hsu Chia-Shuo , Chiang Wei-Hung , Tsai Ming-Kang , Chen Hao Ming 
Published: July 2020

AbstractCopper electrocatalysts have been shown to selectively reduce carbon dioxide to hydrocarbons. Nevertheless, the absence of a systematic study based on time-resolved spectroscopy renders the functional agent—either metallic or oxidative Copper—for the selectivity still undecidable. Herein, we develop an operando seconds-resolved X-ray absorption spectroscopy to uncover the chemical state evolution of working catalysts. An oxide-derived Copper electrocatalyst is employed as a model catalyst to offer scientific insights into the roles metal states serve in carbon dioxide reduction reaction (CO2RR). Using a potential switching approach, the model catalyst can achieve a steady chemical state of half-Cu(0)-and-half-Cu(I) and selectively produce asymmetric C2 products - C2H5OH. Furthermore, a theoretical analysis reveals that a surface composed of Cu-Cu(I) ensembles can have dual carbon monoxide molecules coupled asymmetrically, which potentially enhances the catalyst’s CO2RR product selectivity toward C2 products. Our results offer understandings of the fundamental chemical states and insights to the establishment of selective CO2RR.
Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization
Authors: Zhang Jing , Mazur Ewa , Balla Jozef , Gallei Michelle , Kalousek Petr , Medveďová Zuzana , Li Yang , Wang Yaping , Prát Tomáš , Vasileva Mina , Reinöhl Vilém , Procházka Stanislav , Halouzka Rostislav , Tarkowski Petr , Luschnig Christian , Brewer Philip B. , Friml Jiří 
Published: July 2020

AbstractDirectional transport of the phytohormone auxin is a versatile, plant-specific mechanism regulating many aspects of plant development. The recently identified plant hormones, strigolactones (SLs), are implicated in many plant traits; among others, they modify the phenotypic output of PIN-FORMED (PIN) auxin transporters for fine-tuning of growth and developmental responses. Here, we show in pea and Arabidopsis that SLs target processes dependent on the canalization of auxin flow, which involves auxin feedback on PIN subcellular distribution. D14 receptor- and MAX2 F-box-mediated SL signaling inhibits the formation of auxin-conducting channels after wounding or from artificial auxin sources, during vasculature de novo formation and regeneration. At the cellular level, SLs interfere with auxin effects on PIN polar targeting, constitutive PIN trafficking as well as clathrin-mediated endocytosis. Our results identify a non-transcriptional mechanism of SL action, uncoupling auxin feedback on PIN polarity and trafficking, thereby regulating vascular tissue formation and regeneration.
Handedness-dependent quasiparticle interference in the two enantiomers of the topological chiral semimetal PdGa
Authors: Sessi Paolo , Fan Feng-Ren , Küster Felix , Manna Kaustuv , Schröter Niels B. M. , Ji Jing-Rong , Stolz Samuel , Krieger Jonas A. , Pei Ding , Kim Timur K. , Dudin Pavel , Cacho Cephise , Widmer Roland , Borrmann Horst , Shi Wujun , Chang Kai , Sun Yan , Felser Claudia , Parkin Stuart S. P. 
Published: July 2020

AbstractIt has recently been proposed that combining chirality with topological band theory results in a totally new class of fermions. Understanding how these unconventional quasiparticles propagate and interact remains largely unexplored so far. Here, we use scanning tunneling microscopy to visualize the electronic properties of the prototypical chiral topological semimetal PdGa. We reveal chiral quantum interference patterns of opposite spiraling directions for the two PdGa enantiomers, a direct manifestation of the change of sign of their Chern number. Additionally, we demonstrate that PdGa remains topologically non-trivial over a large energy range, experimentally detecting Fermi arcs in an energy window of more than 1.6 eV that is symmetrically centered around the Fermi level. These results are a consequence of the deep connection between chirality in real and reciprocal space in this class of materials, and, thereby, establish PdGa as an ideal topological chiral semimetal.
Simple descriptor derived from symbolic regression accelerating the discovery of new perovskite catalysts
Authors: Weng Baicheng , Song Zhilong , Zhu Rilong , Yan Qingyu , Sun Qingde , Grice Corey G. , Yan Yanfa , Yin Wan-Jian 
Published: July 2020

AbstractSymbolic regression (SR) is an approach of interpretable machine learning for building mathematical formulas that best fit certain datasets. In this work, SR is used to guide the design of new oxide perovskite catalysts with improved oxygen evolution reaction (OER) activities. A simple descriptor, μ/t, where μ and t are the octahedral and tolerance factors, respectively, is identified, which accelerates the discovery of a series of new oxide perovskite catalysts with improved OER activity. We successfully synthesise five new oxide perovskites and characterise their OER activities. Remarkably, four of them, Cs0.4La0.6Mn0.25Co0.75O3, Cs0.3La0.7NiO3, SrNi0.75Co0.25O3, and Sr0.25Ba0.75NiO3, are among the oxide perovskite catalysts with the highest intrinsic activities. Our results demonstrate the potential of SR for accelerating the data-driven design and discovery of new materials with improved properties.