bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Christianization of African Traditional Religions
Authors: Turaki Yusufu 
Published: November 2019

AbstractIn studies of the historical growth and spread of Christianity in Africa, the focus has been too much on Christianizing African social and religious institutions and structures, and not enough on African traditional religion itself, which needs to be addressed by Christianity. This article addresses the core – that is, the theology and worldview – of the African traditional religion. It argues that this core needs to be Christianized and shows how this can be done. In order to achieve this task, the article uses a new theological method, a “systematic theology” of African traditional religion, as the basis for a theological method of engagement and interaction of religions and worldview. This new method explains in practical terms how Christianity can effectively Christianize African traditional religions and worldviews.
Systematic review of negative pressure wound therapy for head and neck wounds with fistulas: Outcomes and complications
Authors: Lin Fu‐Yu , Huang Pin‐Yi , Cheng Hsu‐Tang 
Published: November 2019

AbstractFistula formation in head and neck wounds is considered one of the most challenging complications that a head and neck reconstructive surgeon may encounter. The current mainstay of treatment is aggressive surgical debridement followed by vascularised soft tissue coverage. Negative pressure wound therapy (NPWT) has been successfully used for the closure of complicated wounds for decades. This study analysed the outcomes and complications of NPWT in the management of head and neck wounds with fistulas. A systematic search of studies published between January 1966 and September 2019 was conducted using the PubMed, MEDLINE, EMBASE, and SCOPUS databases and using the following key words: “negative pressure wound therapy,” “head and neck,” and “fistula.” We included human studies with abstract and full text available. Analysed endpoints were rate of fistula closure, follow‐up duration, and complications if present. Nine retrospective case series (Level IV evidence) that collectively included 122 head and neck wounds with orocutaneous fistulas, pharyngocutaneous fistulas, and salivary contamination were examined. The number of patients included in each study ranged from 5 to 64. The mode of NPWT varied among the included studies, with most adopting a continuous pressure of −125 mm Hg. Mean durations of NPWT ranged from 3.7 to 23 days, and the reported fistula closure rate ranged from 78% to 100%. To achieve complete wound healing, six studies used additional procedures after stopping NPWT, including conventional wound dressings and vascularised tissue transfer. Information regarding follow up was provided in only three of the nine studies, where patients were followed for 5, 10, and 18 months. No serious adverse events were reported. NPWT for head and neck wounds with fistulas may be considered a safe treatment method that yields beneficial outcomes with a low risk of complications. The current data originated mainly from studies with low levels of evidence characterised by heterogeneity. Therefore, definitive recommendations based on these data cannot be offered. Additional high‐quality trials are warranted to corroborate the findings of this systematic review.
What the State Owes ‘Bastards’: A Modest Critique of Modest One‐Child Policies
Authors: Anderson Matthew Lee 
Published: November 2019

AbstractThis essay criticises ‘modest’ one‐child policies, which would impose sanctions upon parents who create multiple children. Specifically, this article considers what the state owes individuals who would be born (illegally) beneath restrictive procreative policies and argues that such policies would fail to show due respect to second‐ or third‐born individuals created beneath them. First, I argue that modest procreative restrictions (like sanctions) are likely to generate only modest compliance. I then suggest it is reasonable to think a one‐child policy fails to demonstrate due respect to existing second and third children. I argue that such a policy generates an undue burden on any second or third children who would be born beneath them, before concluding by considering whether the state might be able to avoid effectively reinscribing ‘bastardy’ into its law by locating responsibility for the effects of such a policy entirely on the parents, rather than on children.
The multifaceted role of CARD9 in inflammatory bowel disease
Authors: Luo Ping , Yang Zhiwen , Chen Bin , Zhong Xiaoming 
Published: November 2019

AbstractInflammatory bowel disease (IBD) involves a dysregulated immune response to the gut microbiota. Emerging evidence has demonstrated that dysfunctions in caspase recruitment domain‐containing protein 9 (CARD9) may contribute to the pathogenesis of IBD. Interestingly, an allelic series of Card9 variants have both a common predisposing and rare protective function in IBD patients. In this review, we provide mechanistic insights into the role of the CARD9 adaptor molecule in intestinal inflammation and determine a potential CARD9‐targeting therapeutic approach against IBD.
A tale of worldwide success: Behind the scenes of Carex (Cyperaceae) biogeography and diversification
Authors: Martín‐Bravo Santiago , Jiménez‐Mejías Pedro , Villaverde Tamara , Escudero Marcial , Hahn Marlene , Spalink Daniel , Roalson Eric H. , Hipp Andrew L. ,   the Global Carex Group, Benítez‐Benítez Carmen , P. Bruederle Leo , Fitzek Elisabeth , A. Ford Bruce , A. Ford Kerry , Garner Mira , Gebauer Sebastian , H. Hoffmann Matthias , Jin Xiao‐Feng , Larridon Isabel , Léveillé‐Bourret Étienne , Lu Yi‐Fei , Luceño Modesto , Maguilla Enrique , Márquez‐Corro Jose Ignacio , Míguez Mónica , Naczi Robert , A. Reznicek Anton , R. Starr Julian 
Published: November 2019

AbstractThe megadiverse genus Carex (c. 2000 species, Cyperaceae) has a nearly cosmopolitan distribution, displaying an inverted latitudinal richness gradient with higher species diversity in cold‐temperate areas of the Northern Hemisphere. Despite great expansion in our knowledge of the phylogenetic history of the genus and many molecular studies focusing on the biogeography of particular groups during the last few decades, a global analysis of Carex biogeography and diversification is still lacking. For this purpose, we built the hitherto most comprehensive Carex‐dated phylogeny based on three markers (ETS–ITS–matK), using a previous phylogenomic Hyb‐Seq framework, and a sampling of two‐thirds of its species and all recognized sections. Ancestral area reconstruction, biogeographic stochastic mapping, and diversification rate analyses were conducted to elucidate macroevolutionary biogeographic and diversification patterns. Our results reveal that Carex originated in the late Eocene in E Asia, where it probably remained until the synchronous diversification of its main subgeneric lineages during the late Oligocene. E Asia is supported as the cradle of Carex diversification, as well as a “museum” of extant species diversity. Subsequent “out‐of‐Asia” colonization patterns feature multiple asymmetric dispersals clustered toward present times among the Northern Hemisphere regions, with major regions acting both as source and sink (especially Asia and North America), as well as several independent colonization events of the Southern Hemisphere. We detected 13 notable diversification rate shifts during the last 10 My, including remarkable radiations in North America and New Zealand, which occurred concurrently with the late Neogene global cooling, which suggests that diversification involved the colonization of new areas and expansion into novel areas of niche space.
Firm capital dynamics in centrally cleared markets
Authors: Capponi Agostino , Cheng W. Allen , Rajan Sriram 
Published: November 2019

AbstractWe develop a tractable continuous time model of multifirm capital dynamics in a centrally cleared market. Our framework jointly models the strategic interactions between business operations of firms and their trading activities. We show that the endogenous allocation of firm capital between trading and operations can be recovered as the unique fixed point of a system of quadratic equations. Our model predicts that (a) there exists a convex relationship between equilibrium margins and firm capital in the cross‐section, (b) market collateral demand is positively correlated with size concentration, and (c) size concentration is expected to increase over time. Using proprietary data on bilateral credit default swap exposures, we provide evidence that the convexity prediction is both economically and statistically significant and validate our model assumption that firms hedge excess risks.
Using pre‐ and postexploitation samples to assess the impact of commercial whaling on the genetic characteristics of eastern North Pacific gray and humpback whales and to compare methods used to infer historic demography
Authors: Béland Stephanie L. , Frasier Brenna A. , Darling James D. , Frasier Timothy R. 
Published: November 2019

AbstractMany species of whales went through recent bottlenecks due to commercial whaling. These declines were rapid and recent relative to the life spans and generation times of these species, raising questions regarding to what degree commercial whaling influenced the genetic characteristics of these populations. We analyzed mitochondrial and nuclear DNA from pre‐ and postwhaling samples from two populations that have arguably shown the greatest degree of recovery: eastern North Pacific gray and humpback whales. We also compare the performance of different methods to test for historic bottlenecks and infer past demography based on genetic data. We found substantially higher levels of genetic diversity in gray than in humpback whales (for both time periods), likely due to recent connectivity between Atlantic and Pacific gray whale populations. Other than mitochondrial diversity in humpback whales, levels of diversity were not lower in contemporary samples relative to prewhaling samples, indicating that commercial whaling had a minimal impact on metrics of genetic diversity themselves. However, it did have large impacts on the patterns of diversity, as evidenced by all coalescent‐based methods showing clear evidence of a bottleneck for both populations, whereas all but one method not based on the coalescent failed to detect a bottleneck.
PLX3397 inhibits the accumulation of intra‐tumoral macrophages and improves bromodomain and extra‐terminal inhibitor efficacy in melanoma
Authors: Erkes Dan A. , Rosenbaum Sheera R. , Field Conroy O. , Chervoneva Inna , Villanueva Jessie , Aplin Andrew E. 
Published: November 2019

AbstractBromodomain and extra‐terminal inhibitors (BETi) delay tumor growth, in part, through tumor cell intrinsic alterations and initiation of anti‐tumor CD8+ T‐cell responses. By contrast, BETi effects on pro‐tumoral immune responses remain unclear. Here, we show that the next‐generation BETi, PLX51107, delayed tumor growth to differing degrees in Braf V600E melanoma syngeneic mouse models. These differential responses were associated with the influx of tumor‐associated macrophages during BETi treatment. Tumors that were poorly responsive to PLX51107 showed increased influx of colony‐stimulating factor‐1 receptor (CSF‐1R)‐positive tumor‐associated macrophages. We depleted CSF‐1R+ tumor‐associated macrophages with the CSF‐1R inhibitor, PLX3397, in combination with PLX51107. Treatment with PLX3397 enhanced the efficacy of PLX51107 in poorly responsive Braf V600E syngeneic melanomas in vivo. These findings suggest that tumor‐associated macrophage accumulation limits BETi efficacy and that co‐treatment with PLX3397 can improve response to PLX51107, offering a potential novel combination therapy for metastatic melanoma patients.
Identification of Protective Actions to Reduce the Vulnerability of Safety‐Critical Systems to Malevolent Intentional Acts: An Optimization‐Based Decision‐Making Approach
Authors: Wang T. R. , Pedroni N. , Zio E. , Mousseau V. 
Published: November 2019

AbstractAn empirical classification model based on the Majority Rule Sorting (MR‐Sort) method has been previously proposed by the authors to evaluate the vulnerability of safety‐critical systems (in particular, nuclear power plants [NPPs]) with respect to malevolent intentional acts. In this article, the model serves as the basis for an analysis aimed at determining a set of protective actions to be taken (e.g., increasing the number of monitoring devices, reducing the number of accesses to the safety‐critical system) in order to effectively reduce the level of vulnerability of the safety‐critical systems under consideration.In particular, the problem is here tackled within an optimization framework: the set of protective actions to implement is chosen as the one minimizing the overall level of vulnerability of a group of safety‐critical systems. In this context, three different optimization approaches have been explored: (i) one single classification model is built to evaluate and minimize system vulnerability; (ii) an ensemble of compatible classification models, generated by the bootstrap method, is employed to perform a “robust” optimization, taking as reference the “worst‐case” scenario over the group of models; (iii) finally, a distribution of classification models, still obtained by bootstrap, is considered to address vulnerability reduction in a “probabilistic” fashion (i.e., by minimizing the “expected” vulnerability of a fleet of systems). The results are presented and compared with reference to a fictitious example considering NPPs as the safety‐critical systems of interest.
Volume incompliance and transfusion are essential for transfusion‐associated circulatory overload: a novel animal model
Authors: Klanderman Robert B. , Bosboom Joachim J. , Maas Adrie A.W. , Roelofs Joris J.T.H. , de Korte Dirk , van Bruggen Robin , van Buul Jaap D. , Zuurbier Coert J. , Veelo Denise P. , Hollmann Markus W. , Vroom Margreeth B. , Juffermans Nicole P. , Geerts Bart F. , Vlaar Alexander P.J. 
Published: November 2019

AbstractBACKGROUNDTransfusion‐associated circulatory overload (TACO) is the predominant complication of transfusion resulting in death. The pathophysiology is poorly understood, but inability to manage volume is associated with TACO, and observational data suggest it is different from simple cardiac overload due to fluids. We developed a two‐hit TACO animal model to assess the role of volume incompliance (“first‐hit”) and studied whether volume overload (“second‐hit”) by red blood cell (RBC) transfusion is different compared to fluids (Ringer's lactate [RL]).MATERIALS AND METHODSMale adult Lewis rats were stratified into a control group (no intervention) or a first hit: either myocardial infarction (MI) or acute kidney injury (AKI). Animals were randomized to a second hit of either RBC transfusion or an equal volume of RL. A clinically relevant difference was defined as an increase in left ventricular end‐diastolic pressure (ΔLVEDP) of +4.0 mm Hg between the RBC and RL groups.RESULTSIn control animals (without first hit) LVEDP was not different between infusion groups (Δ + 1.6 mm Hg). LVEDP increased significantly more after RBCs compared to RL in animals with MI (Δ7.4 mm Hg) and AKI (Δ + 5.4 mm Hg), respectively. Volume‐incompliant rats matched clinical TACO criteria in 92% of transfused versus 25% of RL‐infused animals, with a greater increase in heart rate and significantly higher blood pressure.CONCLUSIONTo our knowledge, this is the first animal model for TACO, showing that a combination of volume incompliance and transfusion is essential for development of circulatory overload. This model allows for further testing of mechanistic factors as well as therapeutic approaches.
Antibody levels to Malassezia pachydermatis and Staphylococcus pseudintermedius in atopic dogs and their relationship with lesion scores
Authors: Khantavee Nathrada , Chanthick Chanettee , Sookrung Nitat , Prapasarakul Nuvee 
Published: November 2019

BackgroundElevated immunoglobulin E (IgE) levels to Malassezia or Staphylococcus species in human atopic dermatitis are related to the skin severity index; a similar association has not been reported in atopic dogs.ObjectivesTo investigate serum levels of allergen‐specific IgE, total specific IgG and IgG subclasses (IgG1 and IgG2) for M. pachydermatis and S. pseudintermedius, and to correlate them with the severity of dermatitis in dogs.AnimalsSerum samples were collected from dogs categorized by age and disease status. Groups 1 and 2: <3‐year‐old healthy (n = 9) and atopic dogs (n = 9), respectively; and groups 3 and 4: ≥3‐year‐old healthy (n = 11) and atopic dogs (n = 14), respectively.Methods and materialsAntibody levels were measured by ELISA. The Canine Atopic Dermatitis Lesion Index (CADLI) was analyzed in relation to antibody levels.ResultsSpecific IgE and total IgG against M. pachydermatis and S. pseudintermedius were significantly increased in atopic dogs of all ages. Although differences between atopic and healthy dogs, with regard to specific IgG1 and IgG2 levels to each microbe, varied in significance within age groups. No significant relationships were found between the CADLI and any specific immunoglobulin levels for both microbe types.Conclusions and clinical importanceIn dog skin, microbes may act as allergens triggering inflammatory responses via IgE‐ and IgG‐dependent pathway(s). The affinity of the IgG subclass produced may vary according to antigen type. Specific IgE levels may be related to clinical disease in dogs and not to skin lesion severity.
Immediate brain plasticity after one hour of brain–computer interface (BCI)
Authors: Nierhaus Till , Vidaurre Carmen , Sannelli Claudia , Mueller Klaus‐Robert , Villringer Arno 
Published: November 2019

Key points
Two groups of inexperienced brain‐computer interface users underwent a purely mental EEG‐BCI session that rapidly impacted on their brain.
Modulations in structural and functional MRI were found after only 1 h of BCI training.
Two different types of BCI (based on motor imagery or visually evoked potentials) were employed and analyses showed that the brain plastic changes are spatially specific for the respective neurofeedback.
This spatial specificity promises tailored therapeutic interventions (e.g. for stroke patients).
AbstractA brain‐computer‐interface (BCI) allows humans to control computational devices using only neural signals. However, it is still an open question, whether performing BCI also impacts on the brain itself, i.e. whether brain plasticity is induced. Here, we show rapid and spatially specific signs of brain plasticity measured with functional and structural MRI after only 1 h of purely mental BCI training in BCI‐naive subjects. We employed two BCI approaches with neurofeedback based on (i) modulations of EEG rhythms by motor imagery (MI‐BCI) or (ii) event‐related potentials elicited by visually targeting flashing letters (ERP‐BCI). Before and after the BCI session we performed structural and functional MRI. For both BCI approaches we found increased T1‐weighted MR signal in the grey matter of the respective target brain regions, such as occipital/parietal areas after ERP‐BCI and precuneus and sensorimotor regions after MI‐BCI. The latter also showed increased functional connectivity and higher task‐evoked BOLD activity in the same areas. Our results demonstrate for the first time that BCI by means of targeted neurofeedback rapidly impacts on MRI measures of brain structure and function. The spatial specificity of BCI‐induced brain plasticity promises therapeutic interventions tailored to individual functional deficits, for example in patients after stroke.
Tectono-sedimentary evolution of a fossil ocean-continent transition: Tasna nappe, central Alps (SE Switzerland)
Authors: Ribes Charlotte , Petri Benoit , Ghienne Jean-François , Manatschal Gianreto , Galster Federico , Karner Garry D. , Figueredo Patricio H. , Johnson Christopher A. , Karpoff Anne-Marie 
Published: November 2019

AbstractMagma-poor ocean-continent transitions at distal rifted margins record complex stratigraphic interactions engendered by extreme crustal thinning and mantle exhumation. The Tasna ocean-continent transition, exposed in the Middle Penninic Tasna nappe in eastern Switzerland, is so far the only known example where the lateral transition from continental crust to exhumed serpentinized mantle lithosphere is exposed and not overprinted by later Alpine deformation. This paper presents sedimentological, structural, and petrographical observations and detrital zircon provenance data to document: (1) the processes controlling continental hyperextension and mantle exhumation; and (2) the facies, depositional systems, sediment sources, delivery pathways, and depositional stacking patterns associated with magma-poor ocean-continent transitions. Our results show that the basement units of the Tasna ocean-continent transition are composed of prerift upper and lower crust and subcontinental mantle rocks juxtaposed as part of the continental crustal thinning process. The absence of pervasive, synrift deformation in the lower-crustal rocks indicates that the thinning was likely achieved by deformation along localized shear zones before being exhumed at the seafloor by brittle, late extensional detachment faulting and not by any form of lower-crustal flow.The age of the first sediments deposited on the continental crust and exhumed mantle, the so-called Tonschiefer Formation, is considered to be Late Jurassic. A key observation is that the restored morpho-tectonic and sedimentary evolution of the Tasna ocean-continent transition shows the intercalation of downdip, transported platform-derived sediments and along-axis–derived siliciclastic sediments originating from the recycling of prerift sediments, local basement, and/or extra-Alpine sources.