bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Epigenetic Alterations in the Development of Oral Diseases
Authors: Emfietzoglou Rodopi , Pachymanolis Evangelos , Piperi Christina 
Published: January 2020

Background:
Epigenetic mechanisms alter gene expression and regulate vital cellular
processes that contribute to the onset and progression of major dental diseases. Their reversible character
may prove beneficial for therapeutic targeting. This review aims to provide an update on the
main epigenetic changes that contribute to the pathogenesis of Oral Squamous Cell Carcinoma
(OSCC), pulpitis and periodontitis as well as dental caries and congenital orofacial malformations, in
an effort to identify potential therapeutic targets.

Methods:
We undertook a structured search of bibliographic databases (PubMed and MEDLINE) for
peer-reviewed epigenetic research studies focused on oral diseases in the last ten years. A qualitative
content analysis was performed in screened papers and a critical discussion of main findings is provided.

Results:
Several epigenetic modifications have been associated with OSCC pathogenesis, including
promoter methylation of genes involved in DNA repair, cell cycle regulation and proliferation leading
to malignant transformation. Additionally, epigenetic inactivation of tumor suppressor genes, overexpression
of histone chaperones and several microRNAs are implicated in OSCC aggressiveness.
Changes in the methylation patterns of IFN-γ and trimethylation of histone Η3Κ27 have been detected
in pulpitis, along with an aberrant expression of several microRNAs, mainly affecting cytokine production.
Chronic periodontal disease has been associated with modifications in the methylation patterns
of Toll-Like Receptor 2, Prostaglandin synthase 2, E-cadherin and some inflammatory cytokines,
along with the overexpression of miR-146a and miR155. Furthermore, DNA methylation was
found to regulate amelogenesis and has been implicated in the pathogenesis of dental caries as well as
in several congenital orofacial malformations.

Conclusion:
Strong evidence indicates that epigenetic changes participate in the pathogenesis of oral
diseases and epigenetic targeting may be considered as a complementary therapeutic scheme to the
current management of oral health.
Natural Inorganic Ingredients in Wound Healing
Authors: García-Villén Fátima , Souza Iane M.S. , de Melo Barbosa Raquel , Borrego-Sánchez Ana , Sánchez-Espejo Rita , Ojeda-Riascos Santiago , Iborra César V. 
Published: January 2020

Background:
One of the major clinical challenges is to achieve a rapid and efficient treatment of complex chronic wounds. Nowadays, most wound dressings currently available are unable to find a solution the challenges of resistance to bacterial infection, protein adsorption and increased levels of exudates. Natural inorganic ingredients (clay minerals, metal cations, zeolites, etc) could be the key to solve the problem satisfactorily. Some of these materials have shown biocompatibility and ability to enhance cell adhesion, proliferation and cellular differentiation and uptake. Besides, some natural inorganic ingredients effectively retain drugs, allowing the design of drug delivery matrices.

Objective:
possibilities of natural inorganic ingredients in wound healing treatments have been reviewed, the following sections have been included:
1. Introduction
2. Functions of Inorganic Ingredients in wound healing
2.1. Antimicrobial effects
2.2. Hemostatic effects
3. Clay minerals for wound healing
3.1. Clay minerals
3.2. Clay mineral semisolid formulations
3.3. Clay/polymer composites and nanocomposites
3.4. Clay minerals in wound dressings
4. Other inorganic materials for wound healing
4.1. Zeolites
4.2. Silica and other silicates
4.3. Other minerals
4.4. Transition metals
5. Conclusion

Conclusion:
inorganic ingredients possess useful features in the development of chronic wounds advanced treatments. They improve physical (mechanical resistance and water vapor transmission), chemical (release of drugs, hemostasis and/or adsorption of exudates and moisture) and biological (antimicrobial effects and improvement of healing) properties of wound dressings. In summary, inorganic ingredients have proved to be a promising and easily accessible products in the treatment of wounds and, more importantly, chronic wounds.
A Pooled Analysis of the Prognostic Significance of Brugada Syndrome with Atrial Fibrillation
Authors: Tian Chao , An Na , Yuan Mengchen , Wang Liqin , Zhang Hanlai , Li Xinye , Yang Xinyu , Li Yanda , Kusano Kengo F. , Gao Yonghong , Xing Yanwei 
Published: January 2020

Background:
Guidelines have previously suggested that atrial fibrillation (AF) is associated with an
increased risk of arrhythmic death in Brugada syndrome (BrS) patients. However, only two articles consisting of
17 AF patients with BrS supported these views. The risk stratification of BrS patients with AF remains controversial.
Thus, a meta-analysis is used to estimate the risk stratification of BrS patients with AF.

Methods:
We searched for relevant studies published from 2000 to December 30, 2018. A total of 1712 patients
with BrS from five studies were included: 200 patients (12%) were reported with AF, among whom 37 patients
(19%) had arrhythmic events.

Results:
BrS patients with AF in all studies (OR 1.92, 95% CI:0.91to 4.04, P =0.09; Heterogeneity: P = 0.03,
I2=61%) and some European studies (OR 1.12, 95% CI: 0.18 to 6.94, P=0.91; Heterogeneity: P = 0.006, I2=80%)
did not display a higher risk of arrhythmic events than those without AF, but BrS patients with AF in Japanese
studies (OR 2.32, 95% CI: 1.37 to 3.93, P=0.002; Heterogeneity: P = 0.40, I2=0%) had a higher risk of arrhythmic
events than those without AF. The proportion of BrS patients with AF was greater in Japanese studies than in
some European studies (16% vs. 9%, P<0.001).

Conclusions:
On the whole, BrS patients with AF showed no higher risk of arrhythmic events than those without
AF, but BrS patients with AF in Japan had a higher risk of arrhythmic events than those without AF.
Clinical and Neuropsychological Predictors of Methylphenidate Response in Children and Adolescents with ADHD: A Naturalistic Follow-up Study in a Spanish Sample
Authors: Vallejo-Valdivielso María , de Castro-Manglano Pilar , Díez-Suárez Azucena , Marín-Méndez Juan J. , Soutullo Cesar A. 
Published: January 2020

Background:Methylphenidate (MPH) is the most commonly used medication for Attention-Deficit/Hyperactivity Disorder (ADHD), but to date, there are neither consistent nor sufficient findings on conditions differentiating responsiveness to MPH response in ADHD.Objective:To develop a predictive model of MPH response, using a longitudinal and naturalistic follow-up study, in a Spanish sample of children and adolescents with ADHD.Methods:We included all children and adolescents with ADHD treated with MPH in our outpatient Clinic (2005 to 2015), evaluated with the K-SADS interview. We collected ADHD-RS-IV.es and CGI-S scores at baseline and at follow up, and neuropsychological testing (WISC-IV, Continuous Performance Test (CPT-II) & Stroop). Clinical response was defined as>30% reduction from baseline of total ADHD-RS-IV.es score and CGI-S final score of 1 or 2 maintained for the previous 3 months.Results:We included 518 children and adolescents with ADHD, mean (SD) age of patients was 11.4 (3.3) years old; 79% male; 51.7% had no comorbidities; and 75.31% had clinical response to a mean MPH dose of 1.2 mg/kg/day. Lower ADHD-RS-IV.es scores, absence of comorbidities (oppositional-defiant symptoms, depressive symptoms and alcohol/cannabis use), fewer altered neuropsychological tests, higher total IQ and low commission errors in CPT-II, were significantly associated with a complete clinical response to methylphenidate treatment.Conclusion:Oppositional-defiant symptoms, depressive symptoms, and a higher number of impaired neuropsychological tests are associated with worse clinical response to methylphenidate. Other stimulants or non-stimulants treatment may be considered when these clinical and neuropsychological variables converged in the first clinical interview.
Synthesis of Molecularly Imprinted Polymers for the Selective Extraction /Removal of 2,4,6-trichlorophenol
Authors: Bhawani Showkat Ahmad , Bakhtiar Salma , Shafqat Syed Rizwan 
Published: January 2020

Background:2,4,6-Trichlorophenol (2,4,6-TCP) is one of the most significant pollutants among chlorophenols due to its harmful effects. It has been classified as priority pollutants by the U.S. Environmental Protection Agency. Therefore, highly selective separation and sensitive recognition of 2,4,6-TCP from complex samples are in great demand.Methods:For this purpose , the preparation of MIPs selective for 2,4,6-TCP was carried out by precipitation polymerization. A non-covalent approach was employed to establish an interaction between template and monomer (methacrylic acid).Results:The resulted polymers were characterized by scanning electron microscopy (SEM), EDX, Fourier-transform infrared spectroscopy(FT-IR) and BET. The batch binding assay was carried out to select the most selective polymer in terms of binding efficiency towards the target template. The adsorption parameters such as initial concentration, dosage of polymer, pH effect and selectivity with structural analogues were determined . The selectivity of MIP towards the 2, 4, 6-TCP was higher as compared to its structural analogue melamine with a good adsorption efficiency. Furthermore, the MIP as an extracting material was applied for extraction of 2, 4, 6-trichlorophenol from the spiked blood serum (88%) and river water sample (94%). The results showed that the optimized MIP could successfully extract 2,4,6-TCP from the blood serum and river water.Conclusion:The molecularly imprinted polymers for 2,4,6-TCP have been prepared by precipitation polymerization with a non-covalent approach. The optimized MIP has been successfully used for the extraction of 2,4,6-TCP from blood serum and river water.
Effect of Fatty Acids Addition into Backfilling Material in Over-cutting Area on Improvement of Lubrication Performance for Pipe Jacking
Authors: Maehara Kazuki , Sasaoka Takashi , Hamanaka Akihiro , Shimada Hideki 
Published: January 2020

Background:The demand for underground space utilization using pipe jacking method is increased especially in the congested urban area.Methods:In the method, the over-cutting area is formed between pipes and surrounding soils in order to smoothly construct underground pipelines. The backfilling materials as a lubricant are injected into the over-cutting area during the constructions in order to reduce the friction resistance and to sustain the surrounding ground against the overburden pressure. Therefore, the performance of lubrication for backfilling material is significant. In this study, the fatty acids are added into the backfilling material to improve the lubrication performance.Conclusion:Laboratory studies have shown that the bleeding rate is reduced with the increase in addition ratio of fatty acids, however, the excess addition may cause the shrinkage of the backfilling material due to the effect of water absorption from the pipe. Additionally, 3% addition of fatty acids into the conventional backfilling material is the most effective to reduce the thrust for pipe jacking based on the results of the direct shear tests.
Fortifikasi Tepung Mangrove Dan Kitosan Terhadap Pertumbuhan Penaeus monodon
Authors: Manik Herkules , Solin Marniati , Thami Khairul , Fitriani Fitriani 
Published: January 2020

Pakan sebagai salah salah satu faktor yang penting untuk peningkatan pertumbuhan dan produktivitas udang. Salah satu pakan yang dapat difortifikasikan dengan pakan udang yaitu tepung magrove dan tepung kitosan yang berpotensi meningkatkan pertumbuhan udang. Tujuan penelitian ini untuk mengetahui pengaruh fortifikasi tepung mangrove dan tepung kitosan terhadap pertumbuhan udang windu. Rancangan yang digunakan rancangan acak kelompok lengkap (RAKL) pola faktorial, dengan 2 faktor perlakuan yaitu tepung mangrove dan tepung kitosan. Pengamatan dilakukan terhadap berat badan dan panjang tubuh udang. Analisis data menggunakan ANOVA pada taraf signifikansi 5% dan DMRT. Hasil penelitian menunjukkan bahwa fotifikasi tepung mangrove 300 g dan tepung kitosan 300 g dapat meningkatkan rerata berat badan dan pajang udang windu setelah perlakuan. Semakin banyak tepung mangrove dan tepung kitosan yang ditambahkan pada pakan komersial, maka pertumbuhan udang semakin meningkat.
Sintesis Silika Dari Abu Sekam Padi Dan Pengaruhnya Terhadap Karakteristik Bata Ringan
Authors: Meliyana Meliyana , Rahmawati Cut , Handayani Lia 
Published: January 2020

Pemanfaatan limbah pertanian yaitu abu sekam padi menjadi silika merupakan upaya untuk mengurangi dampak lingkungan. Abu sekam padi mengandung banyak silika sehingga sangat layak untuk dimanfaatkan. Bata ringan sebagai material dinding memiliki kekurangan terutama pada kuat tekan dan daya serap air, hal ini disebabkan karena penggunaan foaming agent menyebabkan pori-pori membesar dan kuat tekan menurun. Penelitian ini bertujuan untuk mengetahui pengaruh silika yang disintesis dari abu sekam padi terhadap karakteristik bata ringan. Kinerja bata ringan ditinjau terhadap kuat tekan, daya serap air, dan kuat tekan setelah terjadi peningkatan suhu. Sintesis silika dengan metode sol-gel menggunakan NaOH 2,5 N dan HCl 1 N. Dari pengamatan XRF dan FTIR menunjukkan silika yang dihasilkan dari abu sekam padi cukup baik dengan kandungan silika 89,17%. Silika yang dihasilkan dicampurkan ke dalam campuran bata ringan berdasarkan berat semen sebesar 0,5, 10 dan 15%. Massa jenis bata ringan dikontrol pada 800 kg/cm2. Hasil penelitian menunjukkan bata ringan mengalami peningkatan kuat tekan hingga 3,11 MPa, namun pengaruh silika terhadap daya serap air tidak menunjukkan ada pengaruh yang signifikan. Pada pengujian terhadap pembakaran pada suhu 200 – 400°C selama 25 menit menunjukkan ada penurunan kuat tekan, namun bata ringan pada penambahan silika 5% sudah terlihat rapuh. Penambahan silika pada bata ringan dapat diaplikasikan.
O MITO DO DESENVOLVIMENTO SOCIOECONÔMICO DO BRASIL NO SÉCULO XXI: ANÁLISE A PARTIR DOS PLANOS GOVERNAMENTAIS DA ERA LULA
Authors: Rocha Mirella 
Published: January 2020

Esse artigo tem como objetivo referenciar o Brasil na conjuntura latino-americana do século XXI no intuito de analisar o conteúdo do desenvolvimento socioeconômico em curso. Em nossa hipótese, na esteira dos que indicam que o novo século inaugurou na América Morena a reedição da conhecida fórmula do desenvolvimentismo – através do chamado novo-desenvolvimentismo, com sua agenda de desenvolvimento socioeconômico inaugurada no Brasil com o governo do Partido dos Trabalhadores – obscurece as contradições típicas do capitalismo dependente, constituindo-se em um mito. O projeto em curso pode produzir a expansão efêmera da economia, porém, sem as rupturas com a matriz oligárquica que marcam as sociedades periféricas, com seus sistemas de privilégios e de poder antipopular; com sua ossatura histórica assentada na superexploração da força de trabalho. Além disso, é objetivo fundamental desse artigo retomar o legado teórico-político da Teoria Marxista da Dependência, como importante percurso intelectivo para as nossas reflexões e formulações desde Latinoamérica.
الاحتجاج بالقدر في القرآن الكريم
Authors: Fouly Nabil 
Published: January 2020

This paper revolves around those verses of Quranin which Quranstates the argument of the non-believers provide for the justification of their disbelief and acts of polytheism and that is the argument of Qadar.The argument follows that the non-believers are not to be blamed for their disbelieve because these acts are been decreed by God for them. The paper emphasises upon a detail analysis of their argument and upon the quranic response to them by exposing their flawed argumentation and wrong claim. The paper then studies and establishes the position of belief in qadar and it’s position and place within the Islamic belief system, and furthermore studies those different issues which are discussed and dealt within those Quranicverses related to qadar.Moreover the interpretations of those Quranicverses which states this claim of non-believers according to different Mufassirinare studied and analysed and then in the end a general Quranic view regarding how Qurandeals with the issue of “argumentation based upon the concept of Qadar”is presented in the paper
Sundanese Translations of the Qurâ€™an in West Java: Characteristics and the Limits of Translation
Authors: Rohmana Jajang A 
Published: January 2020

There is no target language can fully represent the source language. This study focuses on the problem of differences, uniqueness and limitations of Sundanese as the target language in accommodating Arabic Quran, using the linguistic approach to translation. I use eleven translations of the QuranicÂ Sundanese asthe mainobject. This study shows that there is a similar structure of Sundanese language in the midst of variations of the translation of the Quran. I confirm that the translation of the Quran in Sundanese has limitations and barriers,such as thechange of lexical, word types and unit of semantic and structure of sentences. The most complicated is translation in the form of Sundanese metrical verse orÂ dangding. The translationsof the Quran in Sundanese, unlike the Bible translationsin Christianity, tend to be fettered by the structure of source language.The Sundanese translators generally difficultto use the structure of target language, because it is bounded by their loyaltiesto the source language. Therefore, there are various compromises were taken by translators to bridge the complexity between both target and source language structures. It is an attempt to show inability of Sundaneselanguage to accommodate ArabiclanguageÂ in the midst of rich and complexity of the languageÂ
خصائص التصور الفلسفي للقرآن الكريم والوحي النبوي عند منجي لسود في كتابه "إسلام الفلاسفة"
Authors: Makmun Muhammad , Budiningsih Dessy Yanti Srie 
Published: January 2020

This study tries to present the characteristics of philosophical knowledge of the Qur'an and Prophetic Revelation according to Munji Laswad in his book Islam wa al-Falasifa". This book presents the appearance or manifestation of the philosophers' unity (their perspective on Islam) in several theological discourses based on the characteristics of philosophical perspectives. The author finds that philosophers according to Munji Laswad have special characteristics in seeing and understanding Islam and some of the main concepts in it specifically related to their perspective on the Qur'an and Prophetic Revelation. Among these characteristics is a knowledge (depiction of something) that must be connected with the burhan(demonstrative proposition) which is a special feature of the schools of Islamic philosophy. Even this type of burhanis a differentiator between philosophy and others, either theology, Sufism or jurisprudence
Effect of platelet-rich plasma on the rate of orthodontic tooth movement:
Authors: El-Timamy Ahmed , El Sharaby Fouad , Eid Faten , El Dakroury Amr , Mostafa Yehya , Shaker Olfat 
Published: January 2020

ABSTRACTObjectiveTo investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement.Materials and MethodsSixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale.ResultsThe rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides.ConclusionsPRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.
Tire Rolling Kinematics Model for an Intelligent Tire Based on an Accelerometer
Authors: Wang Yan , Liu Zhe , Kaliske Michael , Wei Yintao 
Published: January 2020

ABSTRACT
The idea of intelligent tires is to develop a tire into an active perception component or a force sensor with an embedded microsensor, such as an accelerometer. A tire rolling kinematics model is necessary to link the acceleration measured with the tire body elastic deformation, based on which the tire forces can be identified. Although intelligent tires have attracted wide interest in recent years, a theoretical model for the rolling kinematics of acceleration fields is still lacking. Therefore, this paper focuses on an explicit formulation for the tire rolling kinematics of acceleration, thereby providing a foundation for the force identification algorithms for an accelerometer-based intelligent tire. The Lagrange–Euler method is used to describe the acceleration field and contact deformation of rolling contact structures. Then, the three-axis acceleration vectors can be expressed by coupling rigid body motion and elastic deformation. To obtain an analytical expression of the full tire deformation, a three-dimensional tire ring model is solved with the tire–road deformation as boundary conditions. After parameterizing the ring model for a radial tire, the developed method is applied and validated by comparing the calculated three-axis accelerations with those measured by the accelerometer. Based on the features of acceleration, especially the distinct peak values corresponding to the tire leading and trailing edges, an intelligent tire identification algorithm is established to predict the tire–road contact length and tire vertical load. A simulation and experiments are conducted to verify the accuracy of the estimation algorithm, the results of which demonstrate good agreement. The proposed model provides a solid theoretical foundation for an acceleration-based intelligent tire.
Folklore as Tradition, Heritage and Profession
Authors: Soni Rohan Kumar 
Published: January 2020

Folklore as a field of study and academic discipline was first recognized following the works of Johann Gottfried Herder in 1770s. The works of Herder, his collection of 'folktales' from German speaking regions is considered the base for later folklore collections, such as those done by the Brothers Grimm and Charles Perrault. Although the discipline of folklore is now well established in various institutions across the Americas, Europe and Africa and Asia. This paper tries to understand folklore in relation with the concepts such as Tradition, Heritage and Profession. How folklore in this fast changing world represents the heritage, tradition, and profession of a community? Can folklore and its performance be appreciated for its inherent economic potential as a profession? The paper, through certain examples and observation, will try to understand the significance of these concepts and attempt to answer such questions.