bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene coexpression patterns predict opiate-induced brain-state transitions
Authors: Brynildsen Julia K. , Mace Kyla D. , Cornblath Eli J. , Weidler Carmen , Pasqualetti Fabio , Bassett Danielle S. , Blendy Julie A. 
Published: July 2020

Significance
Persistent alterations to neural circuitry may help to explain why opiate abuse liability is higher among individuals with a history of chronic exposure. In this study, we employ a unique combination of computational approaches to understand how opiate-induced reorganization of network connectivity is supported by transcriptional and structural features of the brain. We identify a persistent reduction in FOS correlation network strength following opiate dependence and determine that correlated gene expression is predictive of opiate-induced changes in network connectivity. Further, we identify brain regions that influence the transition between opiate-naïve and opiate-dependent states. These findings establish a link between gene expression and changes in brain connectivity in response to opioids.
Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin
Authors: Duan Mingrui , Selvam Kathiresan , Wyrick John J. , Mao Peng 
Published: July 2020

Significance
The mechanism of eukaryotic transcription-coupled nucleotide excision repair (TC-NER) is poorly understood. Here, we studied the genome-wide role of yeast Rad26, a homolog of the human Cockayne syndrome group B (CSB) protein, in the repair of UV-induced DNA damage. We found that Rad26 is not uniformly required for TC-NER in transcribed chromatin. Instead, nucleosome organization and the distribution of transcription regulators such as TFIIH and Spt4/Spt5 significantly modulate the requirement for Rad26 in TC-NER. Importantly, TC-NER is conserved from yeast to humans. Our data provide insights into the mechanism of TC-NER in eukaryotes.
Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy
Authors: Chen Shuliang , Mari Muriel , Parashar Smriti , Liu Dongmei , Cui Yixian , Reggiori Fulvio , Novick Peter J. , Ferro-Novick Susan 
Published: July 2020

SignificanceVps13, a conserved phospholipid transporter, localizes to contact sites between the endoplasmic reticulum (ER) and different organelles. While budding yeast has oneVPS13gene, humans have four. The yeast Vps13 protein is most closely related to VPS13A and VPS13C. VPS13A localizes to ER–mitochondria contact sites, while VPS13C resides at ER–late endosome contact sites. Here we report that thevps13Δ mutant is defective in the selective autophagy of ER (ER-phagy). In the absence of Vps13, the ER accumulates at late endosomes and fails to be packaged into autophagosomes. These findings highlight the importance of Vps13 function at late endosomes in ER-phagy, and may have implications for understanding the role of VPS13C, which has been linked to early-onset Parkinson’s disease.
Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress
Authors: Cooper Melissa L. , Pasini Silvia , Lambert Wendi S. , D’Alessandro Karis B. , Yao Vincent , Risner Michael L. , Calkins David J. 
Published: July 2020

Significance
Astrocytes respond to neuronal energy needs by mobilizing metabolic stores. How these resources are mobilized during neurodegeneration, especially in nearby regions that are not actively degenerating, could impact new therapeutic approaches. We modeled neurodegeneration in glaucoma and measured how metabolites mobilize through astrocyte networks. We elevated pressure in one eye and determined how astrocyte-derived metabolites in the opposite eye and nerve responded. Remarkably, astrocyte networks expand and redistribute metabolites along distances nearly 1 cm in length to donate resources from unstressed to stressed tissue. While resource donation improves axon function and visual acuity, it renders the donating tissue susceptible to further stress, which could help explain why local neurodegeneration eventually impacts healthy regions of the brain.
Clausal ellipsis
Authors: Broekhuis Hans , Bayer Josef 
Published: July 2020

AbstractThis article compares two alternatives to the standard movement-and-deletion approach to clausal ellipsis, which postulates deletion of TP after the remnants of ellipsis are (sometimes exceptionally) A′-moved into the left periphery of the clause. One alternative is thein-situapproach, which denies the involvement of movement in the derivation of clausal ellipsis; it claims that clausal ellipsis can apply toanyrun-of-the-mill syntactic structure and simply deletes the familiar/given information from the propositional domain of the clause. Another alternative is the selective spell-out approach; it denies the involvement of deletion and states that the remnants undergo regular A′-movement into the specifiers of specific semantically relevant functional projections (CP, FocusP, NegP, etc.), which are subsequently selected for spell-out. This article argues that the selective spell-out approach is superior to the two deletion approaches.
Tense and sentential negation
Authors: De Clercq Karen 
Published: July 2020

AbstractThe association between sentential negation and tense has solid foundations in the literature. It has even been argued that sentential negative markers consist of a Tense feature (De Clercq 2018,2020). This paper adduces the first results from a typological study and data from Bambara in support of this claim. In addition, the Bambara data also point to the morphological realisation of present or default tense, to a hierarchy for tense and to a position for sentential negation in that hierarchy.
Person/Number exponents in imperative-enclitic contexts
Authors: Cabré Teresa , Ohannesian Maria 
Published: July 2020

Abstract
The goal of this paper is to analyse the partial or total deletion of the Person/Number exponents in imperative-enclitic contexts in Catalan and Spanish. Both languages lose phonological material in a specific context, but Spanish deletes the right-edge segment from the verb whereas Barcelona Catalan loses the left-edge segment of the clitic. Our aim is to account for the contrasting solutions shown by these two neighbouring languages using the same constraints but ranked differently in the Optimality Theory framework. OT allows us to put together different types of grammatical requirements, including distinctness requirements, particularly a positional OCP constraint on Person/Number features, and faithfulness conditions, specifically the condition related with morpheme realization, all of which interact with alignment and markedness constraints.
Computational quantitative syntax
Authors: Gulordava Kristina , Merlo Paola 
Published: July 2020

Abstract
Accounting for the constraints on the possible word orders of a sentence in a language and across the world languages is a core challenge for syntactic theory. In the spirit of computational quantitative syntax, in this paper we present quantitative evidence about Universal 18. We show that corpus data confirms a dispreference for the word order combination where adjectives precede but numerals follow the nouns (Adj-N and N-Num). We then investigate if this dispreference is better explained as a constraint expressed at the level of the dominant orders or at the level of individual structures. Corpus counts support the latter interpretation. Finally, we propose a formal model of how this bias against Adj-N-Num orders can be integrated in the grammar.
On recomplementation, high adverbs and V-movement in Spanish
Authors: Martínez Vera Gabriel 
Published: July 2020

Abstract
I address the structure of the Spanish left periphery regarding recomplementation, i.e., double-complementizer constructions. I establish a contrast between Latin American Spanish (LAS) and European Spanish (ES): while there is an overt low complementizer que in ES, there is a null low complementizer in LAS – this is a novel empirical observation. The latter is different from the construction where low que is absent in ES: the null low complementizer in LAS patterns with the overt low complementizer in ES with respect to the phenomena discussed in this paper. I further tie this difference to the height of V-movement and adverb placement in LAS and ES. I then propose a phase-based account of the contrast.
Inflected infinitives in Galician
Authors: Sheehan Michelle , Blokzijl Jeffrey , Parafita Couto M. Carmen 
Published: July 2020

Abstract
This study uses an audio-questionnaire, supplemented by spoken corpus data, to probe the acceptability of Galician inflected infinitives in different syntactic contexts. Our results reveal that inflected infinitives in Galician are acceptable in a different range of contexts than in closely related Portuguese, and also in a broader range of contexts than previously reported for this language. Intra-speaker variation appears to correlate most strongly with L1 (Spanish/Galician) and gender, with a trend for men and L1 Spanish speakers to be more accepting of the inflected infinitive.
Prescription Drug Misuse, other Substance Use, and Sexual Identity: The Significance of Educational Status and Psychological Distress in US Young Adults
Authors: Klare Dalton L. , McCabe Sean Esteban , Ford Jason A. , Schepis Ty S. 
Published: July 2020

Background The aim was to examine the effects of sexual identity, educational status, and their interaction on the past-year prevalence of controlled prescription use and prescription drug misuse (PDM) in U.S. young adults, 18–25 years. Methods Data were from the 2015–2017 National Survey on Drug Use and Health (young adult N = 38,298). Past-year prescription opioid, stimulant and benzodiazepine use and PDM were outcomes, with PDM defined as use without a prescription or in ways not intended by the prescriber. Separate regressions by sex evaluated the relationship between prescription medication use or PDM prevalence and sexual identity, educational status/attainment (college student/graduate versus non-college), their interaction and past-year psychological distress. Results Sexual identity minority young adults had higher rates of prescription use and PDM than heterosexual young adults. After accounting for educational status, though, bisexual men rarely differed from heterosexual men; after including psychological distress, gay men rarely differed from heterosexual men. Versus heterosexual women, lesbian (adjusted odds ratio [AOR] = 2.33, 95% confidence interval [95% CI] = 1.47–2.30) and bisexual (AOR= 1.78, 95% CI = 1.27–2.50) young adult women had higher rates of prescription opioid misuse, after adjusting for educational status, psychological distress and sociodemographics. Versus heterosexual men, benzodiazepine PDM was elevated in gay men (AOR = 1.91, 95% CI= 1.02–3.58). Educational status was generally associated with lower rates of prescription use and PDM, except for stimulant PDM. Conclusions Screening for psychological distress and PDM is needed in sexual identity minority young adults, especially for prescription opioid misuse among sexual identity minority women. Culturally-sensitive intervention should be considered for those with elevated psychological distress or signs of PDM. Further research on the sex differences found in the link between psychological distress and sexual identity minority opioid and stimulant PDM is warranted.
Discovery of extended structures around two evolved planetary nebulae M2–55 and Abell 2
Authors: Hsia Chih-Hao , Zhang Yong , Zhang Xi-Liang , Luo Tao 
Published: July 2020

Abstract
We report a multi-wavelength study of two evolved planetary nebulae (PNs)M2–55 and Abell 2. Deep optical narrow-band images ([O III], Hα, and [N II]) of M2–55 reveal two pairs of bipolar lobes and a new faint arc-like structure. This arc-shaped filament around M2–55 appears as a well-defined boundary from southwest to southeast, strongly suggesting that this nebula is in interaction with its surrounding interstellar medium. From the imaging data of Wide-field Infrared Survey Explorer (WISE) all-sky survey, we discovered extensive mid-infrared halos around these PNs, which are approximately twice the size of their main nebulae seen in the visible.We also present a mid-resolution optical spectrum of M2–55, which shows that it is a high-excitation evolved PN with a low electron density of 250 cm−3. Furthermore, we investigate the properties of these nebulae from their spectral energy distributions (SEDs) by means of archival data.
The cost of stratospheric aerosol injection through 2100
Authors: Smith Wake 
Published: July 2020

Abstract
This paper presents the estimated direct costs of a stratospheric aerosol injection (SAI) program through the end of this century. It displays a range of future solar geoengineering deployment scenarios that are intended to reduce anthropogenically-caused radiative forcing beginning in 2035. The scenarios reviewed herein include three commonly modeled representative concentration pathways (4.5, 6.0, and 8.5) and three possible radiative forcing targets (halving future warming, halting warming, and reversing temperatures to 2020 levels). The program relies on three successive generations of newly designed high-altitude tanker aircraft to deliver aerosols to an altitude of ∼20 km. Sulfates are assumed to be the aerosol used in conjunction with the first generation tanker, supplanted by an as-yet-determined ‘Aerosol 2’ with the later generation aircraft. The aggregate cost over the remainder of the 21st century and the annual cost in 2100 both vary by an order of magnitude between the cheapest and the most expensive scenarios. However, the cost-per-ton of deployed aerosol varies little among scenarios and the cost-per-degree-of-warming-avoided is similarly consistent. Relative to other climate interventions and solutions, SAI remains inexpensive, but at about $18 billion yr−1 per degree Celsius of warming avoided (in 2020 USD), a solar geoengineering program with substantial climate impact would lie well beyond the financial reach of individuals, small states, or other non-state potential rogue actors and would instead be the exclusive domain of large national economies or coalitions including at least one such economy.
An Artificial Channel Purification Experiment for Arsenic-rich Drainage Water from the Abandoned Mine by using Eleocharis acicularis
Authors: Okazaki Kenji , Yamazaki Shusaku , Kurahashi Toshiyuki , Masayuki  , Sakakibara  
Published: July 2020

Abstract
An artificial channel purification experiment for arsenic-rich drainage water was conducted to investigate the feasibility of phytoremediation by using Eleocharis acicularis. In the experiment, 15 m2 of Eleocharis acicularis mats were laid in an artificial channel in two days. Two sessions of artificial flow were implemented by leading 100 L of mine drainage water containing 7.45 mg/L of arsenic into the channel each time. The arsenic concentration in the Eleocharis acicularis was measured using samples collected at 0 m, 25 m, and 50 m along the channel. As a result of experiments, the arsenic concentrations of the outflow for the two sessions were 1.62 mg/L and 3.12 mg/L. This shows that the arsenic concentration decreased during two sessions, whose flow totalled 200 L. The initial concentration of arsenic in Eleocharis acicularis was 0.18 mg/kg at 0 m point, 0.06 mg/kg at 25 m point and 0.11 mg/kg at 50 m point. After two inflows, the arsenic concentration of Eleocharis acicularis increased from 88.5 mg/kg to 105.0 mg/kg at 0 m, from 29.6 mg/kg to 52.8 mg/kg at 25 m, from 7.2 mg/kg to 37.8 mg/kg at 50 m, respectively, indicating that Eleocharis acicularis absorbs arsenic. This paper describes the results of an artificial channel experiment in which water containing arsenic was purified by using Eleocharis acicularis.
Preliminary Study of Atmospheric Mercury Contamination Assessment Using Tree Bark in an ASGM Area in North Gorontalo Regency, Indonesia
Authors: Prasetia Hendra , Sakakibara Masayuki , Sera Koichiro 
Published: July 2020

AbstractMercury (Hg) atmospheric contamination have been analysed using several indicators. In this study, the tree bark was used to indicate Hg contamination of the atmosphere in ASGM area. This study aimed to determine the potential species to assess Hg atmospheric contamination by using tree bark. The Hg concentration was determined in the tree bark from various tree species. The tree bark was collected at Diameter Breast Height (DBH) which is about 130 cm. The fine powder of tree bark was analysed by PIXE to detect Hg concentration. The results show thatMangifera indica, Lansiumdomesticum, Syzygium aromaticumandArtocarpus heterophyllusspecies accumulate Hg concentration about 4.90 to 10.3, ND to 1.10, ND to 4.42 and 2.43 mg/kg-DW, respectively. This suggests thatM. indica, L. domesticum, S. aromaticum,andA. heterophyllusshow high toxic of Hg contamination in the tree bark compared to tolerable toxic level in the plant.This study indicates that the surface condition of tree bark probably effects on the detection of Hg contamination in each tree species. The tree plant, especially tree bark, is a good candidate to assess Hg atmospheric contamination.
Preliminary Study on Human Lung Function of Artisanal and Small-scale Gold Miner in Gorontalo Province, Indonesia
Authors: Manovita Pateda Sri , Sakakibara Masayuki 
Published: July 2020

Abstract
Effects of mercury from ASGM in humans have been reported in various studies. The effect depends on the dose, the form of mercury, and a way of entering the body. The human body with all its perfection has a remarkable system of defense against external negative effects including toxic effects of mercury. One of the leading defense systems of the human body is the respiratory system, because it is an organ connected directly to the outside environment. Early detection is very necessary to prevent the incidence of more severe, then the initial lung examination is needed and important. For that, there needs to be an examination of the lungs that can be used to find early lung disorders, namely the spirometry test. During this time in each study was only performed blood tests, urine and hair to assess the levels of mercury, but the disease-based examination is limited to only a neuropsychological examination. Spirometry is useful and basic in the diagnosis of lung diseases. In addition to assessing respiratory function primarily assessing breathing pattern, such as pulmonary fibrosis or asthma, it is also very helpful in health surveillance. In the preliminary survey, 4 samples were taken consisting of 2 miner samples and 2 samples non-miners (control). These 4 sample have the same age range, with the same smoking status. The spirometry test result shows that all miner had lung disorders and control samples had normal results. The conclusions from this survey are: (1) Mercury pollution must be a serious attention for all of us; (2) all miners tend to be exposed to evaporated mercury; (3) Spirometry tests can be one of the health examinations for early detection of lung disease.
Application of life cycle cost in the construction of soil retaining wall replacing soldier pile with diaphragm wall (case studi of Pejaten Apartment Projects)
Authors: Monalisa L , Makarim C A 
Published: July 2020

Abstract
In order to obtain efficient design, stable and optimal with a good characteristic of quality, one of the techniques that can be convinced is called life cycle cost. Life cycle cost is a process of determining the amount of costs related to an asset, including initial costs, maintanance costs, and repair costs. It was found that both relationships were significant and positive. The purpose of life cycle cost is to get the saving cost and time efficiency, which does not rule out its function and quality. In this life cycle cost analysis, the diaphragm wall is selected to replace the soldier pile. The cost savings obtained are 23% of the initial cost of the soldier pile’s retaining wall work. The process of diaphragm wall is a lot faster 2-3 times than the work of soldier pile retaining wall. Based on the results of the initial costs and maintanance costs, it can be interpreted that the method of diaphragm wall can allow much greater savings than using the soldier pile retaining wall method.
Curve Number Method to Determine the Runoff Height in the Upper Cimanuk Watershed
Authors: Ariyani Dwi , Aprilia Vera , Tri Juniati Atie , Prautama Dewi Atri , Kurnia Fadli 
Published: July 2020

Abstract
Run off is one of the most important hydrological variables in supporting water resources development planning and activities. To predict the amount of runoff can be done in various ways one of them with the SCS-CN method. The SCS method was developed from years of rainfall observation and involved many agricultural areas in the United States. This method seeks to link watershed characteristics such as soil, vegetation, and land use with a runoff curve number which indicates the potential runoff water for a particular rainfall. The location of this research is Garut Regency, upstream of the Cimanuk river, which often floods every year due to overflowing of the Cimanuk River. Data used to determine CN values and runoff height are Digital Elevation Model (DEM), land use, soil, and rainfall data for the last 10 years, from 2009 to 2018, then the maps are processed using the Arc-Map program. From the analysis it can be seen that the CN value is 66.54%, and the runoff height is 1.17 cm with a 2 year return period, and 2.84 cm at 25 return period. Based on the CN value, it is known that the type of soil in the upstream Cimanuk watershed has a small infiltration rate and has bad properties in infiltrating water, so that it can cause run off for a long time, because the smaller CN value on a land use, so soil’s retention ability is greater and the less chance of runoff. The results of this study can be used for planning flood control buildings in the upper Cimanuk watershed.
Calibration and Validation Indonesian Highway Capacity Manual 1997 Model
Authors: Yulianto Budi , Setiono  , Dewayani Putri Rizki , Tia Pratisca Stevani , Fernando Hartono Felix 
Published: July 2020

Abstract
Population growth and uncontrolled use of vehicles result in changes in traffic behaviours. This has an impact on the validity of the IHCM 1997 model results when replicating traffic in the real conditions. This study aims to carry out calibration and validation IHCM 1997 signalised intersection model. Case studies are conducted at eleven signalized intersection locations in the Surakarta city. The results of study show that the IHCM 1997 method default values are not relevant to the current conditions. The traffic parameters that need to be changed in the IHCM 1997 model are passenger car equivalent (PCE) and base saturation flow (S0).