bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seeing Black: Foote’s Afro-American Company and the Performance of Racial Uplift in Imperial Germany in 1891
Authors: Bowersox Jeff 
Published: July 2020

Abstract
By 1914 African American entertainers had become a regular part of variety show programmes across the German lands, but despite their evident popularity, they have received little scholarly attention except as part of the pre-history of jazz. But even before 1914 African American performers took an active part in transatlantic conversations about the meanings of race, challenging racialized understandings of nation, culture and modernity. To illustrate the challenge presented by African American performance and the range of German responses, this article takes up a little-known case study, the German tour of William Foote’s Afro-American Company in 1891. Led by a white impresario, the show brought together the broad range of black popular performance—minstrel song and dance, jubilee choirs, social dance and concert singing—to demonstrate the rapid progress of African American cultivation since emancipation. This message of racial uplift was framed in ethnographic terms, making a case that African Americans, like Germans, possessed distinctive folk forms that could be refined into cultivated forms with universal value. This framing made an uplifting case for an equivalence between African American and German cultures, but there were also ambivalences built into Foote’s project as organizers played to audiences’ racialized expectations. Analysing German commentators’ responses to performances of American blackness allows us to interrogate competing discourses of blackness in the German lands and the ways they could be used strategically. More broadly, those responses also illustrate how ideas about race were negotiated, produced and popularized in commercial entertainments.
Resting-State Function Connectivity Associated With Being a “Morning-Type” Dementia Caregiver and Having Lower Depression Symptom Severity
Authors: Smagula Stephen F , Karim Helmet T , Ibrahim Tamer S , Krafty Robert T , Stahl Sarah T , Rodakowski Juleen , Reynolds Charles F , Hall Martica H , Aizenstein Howard J 
Published: July 2020

Abstract

Objectives
A lack of “morningness” predicts greater depression symptom severity over time, including in a vulnerable group of older adults: family dementia caregivers (dCGs). Evidence regarding the neurobiological basis of these correlations is needed to guide future research towards biomarker-informed detection and prevention approaches. We therefore primarily aimed to identify simple resting-state biomarkers that correlated with a lack of “morningness” in dCGs.

Method
We examined 54 dCGs (mean age = 70, range: 61–84; 70% female) of whom 40% were definite “morning types” according to Composite Scale of Morningness (CSM). Using a 7 Tesla resting-state sequence, we compared the functional connectivity of nodes in networks previously implicated in depression (fronto-parietal, default mode, limbic, and salience) between caregivers who were and were not “morning types.”

Results
Correcting for voxel-wise comparisons, “morning-type” dCGs had less amygdala–posterior cingulate connectivity (Cohen’s d = −1.3), which statistically mediated ~32% of the association between the degree of “morningness” and lower depression severity. Post hoc analyses of CSM items found significant correlations, with both amygdala–posterior cingulate FC and depression severity, for 4/6 items pertaining to difficulty, 2/5 items pertaining to preference, and 0/2 items pertaining to typical patterns.

Discussion
Prior research shows that amygdala–posterior cingulate connectivity increases when allocating attention to peripheral aspects of negative emotional stimuli. As such, difficulty with morning activation may relate to the ongoing direction of focus around distressing content; in contrast, morning activity participation may serve to limit focus on distress. Replication and experimental studies are required to confirm these associations and their modifiability.
Perceptions of Closeness in Adult Parent–Child Dyads: Asymmetry in the Context of Family Complexity
Authors: van Houdt Kirsten , Kalmijn Matthijs , Ivanova Katya 
Published: July 2020

Abstract

Objectives
Multi-actor data show that parents’ and adult children’s evaluations of their relation do not necessarily match. We studied disagreement in parent- and child-reported closeness, comparing parent–child dyads involving separated parents, non-separated parents, and stepparents to shed new light on today’s diverse landscape of adult parent–child relations.

Method
Using data from the Parents and Children in the Netherlands (OKiN) survey, we analyzed closeness in parent–child dyads (N = 4,602) comparing (step)parents’ and their adult children’s (aged 25–45) reports. To distinguish directional disagreement (i.e., differences in child- and parent-reported means) from nondirectional disagreement (i.e., the association between child- and parent-reported measures), while accounting for absolute levels of closeness, we estimated log-linear models.

Results
All types of parents tend to report higher levels of closeness than their children. Whereas parental overreport is more prevalent among biological father–child dyads than among biological mother–child dyads, we found no differences between biological dyads and stepdyads. The association between children’s and parents’ reports is higher among dyads involving stepmothers or married mothers than among those involving separated mothers and (step)fathers.

Discussion
The intergenerational stake (i.e., parental overreport) is not unique to biological parent–child relations. Instead, patterns of disagreement seem most strongly stratified by gender.
Participation in a Substance Misuse Intervention in Post-acute Care Is Associated With More Optimal Rehabilitation Outcomes
Authors: Cimarolli Verena R , Burack Orah , Minahan Jillian , Hennessa Alexandra , Stone Robyn , Shi Xiaomei 
Published: July 2020

Abstract

Background and Objectives
Alcohol and substance misuse is prevalent among older adults, yet underdiagnosed and undertreated. More substance misuse intervention programs specifically designed for older adults and offered in various settings are needed. This project’s objectives were to (a) provide a detailed description of a Geriatric Substance Abuse Recovery Program (GSARP) designed and implemented at post-acute rehabilitation units of a skilled nursing facility and (b) report findings of a study conducted to evaluate if GSARP participation among post-acute care patients with substance misuse issues can optimize rehabilitation outcomes (i.e., being discharged home vs. another setting).

Research Design and Methods
A pretest–posttest study design with data obtained from patients’ electronic medical record upon facility admission, during post-acute stay, and after discharge (N = 271). Based on Andersen’s model of health care utilization, we investigated which predisposing factors (e.g., ethnicity), enabling factors (e.g., cognition and social support), and need-related factors (e.g., activities of daily living functioning), as well as health behaviors (e.g., GSARP participation) predicted likelihood of being discharged home versus another discharge setting.

Results
Patients participating in the GSARP and patients who received social support from family members and friends during their post-acute stay were more likely to be discharged home. Patients with severe cognitive impairment were less likely to be discharged home.

Discussion and Implications
The GSARP eliminates some common barriers often encountered in the screening and delivery process of substance misuse interventions for older adults. Findings support the effectiveness of the GSARP in optimizing rehabilitation outcomes for older adults with substance misuse issues.
Process evaluation of HAT TRICK: feasibility, acceptability and opportunities for programme refinement
Authors: Sharp Paul , Bottorff Joan L , Oliffe John L , Hunt Kate , Caperchione Cristina M 
Published: July 2020

Abstract
Preventive lifestyle interventions are needed to address challenges in engaging men in conventional health programmes. This process evaluation examined the feasibility and acceptability of HAT TRICK, a gender-sensitized programme targeting physical activity, healthy eating and social connectedness. A mixed-methods approach was utilized to examine the effectiveness of recruitment and selection processes, facilitators’ experiences and challenges and participant experiences with the programme. Evaluation measures included participant flow data and baseline assessments, facilitator debriefs, a post-intervention process evaluation questionnaire and telephone interviews with a subsample of participants. Participants (n = 62) were overweight (body mass index [BMI] &gt; 25 kg m−2) and inactive (&lt;150 min of moderate to vigorous physical activity [MVPA] per week) men with a mean age 51 ± 10.1 years. Participants reported high levels of satisfaction, acceptability and engagement with the intervention programme, content and resources. Facilitators noted the importance of creating a friendly, non-judgemental environment and observed that intervention content was best received when delivered in an interactive and engaging manner. Future programme refinements should consider strategies for strengthening social support, as well as opportunities for leveraging participants’ interest in other health-related issues (e.g. mental health). Findings yield valuable information about the implementation of gender-sensitized interventions for men and demonstrate the importance of male-specific engagement strategies for reaching and engaging overweight, inactive men.
Modelling the antecedent factors that affect online fake news sharing on COVID-19: the moderating role of fake news knowledge
Authors: Apuke Oberiri Destiny , Omar Bahiyah 
Published: July 2020

AbstractWe proposed a conceptual model combining three theories: uses and gratification theory, social networking sites (SNS) dependency theory and social impact theory to understand the factors that predict fake news sharing related to COVID-19. We also tested the moderating role of fake news knowledge in reducing the tendency to share fake news. Data were drawn from social media users (n = 650) in Nigeria, and partial least squares was used to analyse the data. Our results suggest that tie strength was the strongest predictor of fake news sharing related to COVID-19 pandemic. We also found perceived herd, SNS dependency, information-seeking and parasocial interaction to be significant predictors of fake news sharing. The effect of status-seeking on fake news sharing, however, was not significant. Our results also established that fake news knowledge significantly moderated the effect of perceived herd, SNS dependency, information-seeking, parasocial interaction on fake news sharing related to COVID-19. However, tie strength and status-seeking effects were not moderated.
Assembly of the [4Fe–4S] cluster of NFU1 requires the coordinated donation of two [2Fe–2S] clusters from the scaffold proteins, ISCU2 and ISCA1
Authors: Jain Anshika , Singh Anamika , Maio Nunziata , Rouault Tracey A 
Published: July 2020

Abstract
NFU1, a late-acting iron–sulfur (Fe–S) cluster carrier protein, has a key role in the pathogenesis of the disease, multiple mitochondrial dysfunctions syndrome. In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe–S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate the formation of a bridging [4Fe–4S] cluster, aided by ferredoxin 2. By monitoring the abundance of target proteins that acquire their Fe–S clusters from NFU1, we characterized the effects of several novel pathogenic NFU1 mutations. We observed that NFU1 directly interacts with each of the Fe–S cluster scaffold proteins known to ligate [2Fe–2S] clusters, ISCU2 and ISCA1, and we mapped the site of interaction to a conserved hydrophobic patch of residues situated at the end of the C-terminal alpha-helix of NFU1. Furthermore, we showed that NFU1 lost its ability to acquire its Fe–S cluster when mutagenized at the identified site of interaction with ISCU2 and ISCA1, which thereby adversely affected biochemical functions of proteins that are thought to acquire their Fe–S clusters directly from NFU1, such as lipoic acid synthase, which supports the Fe–S-dependent process of lipoylation of components of multiple key enzyme complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the glycine cleavage complex.
Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank
Authors: Gubb Samuel J A , Brcic Lucija , Underwood Jack F G , Kendall Kimberley M , Caseras Xavier , Kirov George , Davies William 
Published: July 2020

Abstract
Deletions spanning the STS (steroid sulfatase) gene at Xp22.31 are associated with X-linked ichthyosis, corneal opacities, testicular maldescent, cardiac arrhythmia, and higher rates of developmental and mood disorders/traits, possibly related to the smaller volume of some basal ganglia structures. The consequences of duplication of the same genomic region have not been systematically assessed in large or adult samples, although evidence from case reports/series has indicated high rates of developmental phenotypes. We compared multiple measures of physical and mental health, cognition and neuroanatomy in male (n = 414) and female (n = 938) carriers of 0.8–2.5 Mb duplications spanning STS, and non-carrier male (n = 192, 826) and female (n = 227, 235) controls from the UK Biobank (recruited aged 40–69 from the UK general population). Clinical and self-reported diagnoses indicated a higher prevalence of inguinal hernia and mania/bipolar disorder respectively in male duplication carriers, and a higher prevalence of gastro-oesophageal reflux disease and blistering/desquamating skin disorder respectively in female duplication carriers; duplication carriers also exhibited reductions in several depression-related measures, and greater happiness. Cognitive function and academic achievement did not differ between comparison groups. Neuroanatomical analysis suggested greater lateral ventricle and putamen volume in duplication carriers. In conclusion, Xp22.31 duplications appear largely benign, but could slightly increase the likelihood of specific phenotypes (although results were only nominally-significant). In contrast to deletions, duplications might protect against depressive symptoms, possibly via higher STS expression/activity (resulting in elevated endogenous free steroid levels), and through contributing towards an enlarged putamen volume. These results should enable better genetic counselling of individuals with Xp22.31 microduplications.
Use of a reabsorbable patch as tracheal substitute in a complicated urgent tracheostomy
Authors: Mammana Marco , Comacchio Giovanni M , Bellini Alice , Rea Federico 
Published: July 2020

Abstract
Airway dehiscence after tracheal resection-anastomosis is a major complication that often requires an urgent reoperation. If ischaemia of the airway is extensive, however, performing a tracheostomy might be complicated. Here, we describe the case of a patient who underwent urgent tracheostomy because of acute airway dehiscence, wherein an absorbable prosthesis was used to repair the defect of the anterior trachea.
Research on optimization strategy of grid frequency modulation based on doubly-fed wind turbines
Authors: Wang Chao , Xu Jianyuan , Wang Liang , Song Dan 
Published: July 2020

Abstract
The increasing global energy and environmental problems are encouraging to the development and utilization of renewable and clean energy in various countries. Wind power is one of the major source in large-scale renewable energy applications. However, the frequency regulation becomes a critical issue while the technology is spreading. Research on the frequency modulation (FM) technology of wind turbines and its control strategy for future power grids become significant. The paper proposes a novel coordinated frequency control strategy with the synchronous generator to solve the unmatched state between the output power of the doubly-fed wind turbines (doubly-fed induction generators) and the grid frequency, combined with the frequency response characteristics of the synchronous generator. The FM coordination strategy is formulated by the modulation coefficient from current wind speed and operation mode of each wind turbine. By coordinating the FM output of the doubly-fed wind turbine and the synchronous generator within the allowable range of frequency deviation, it will achieve the dual goal of reducing the frequency regulation pressure of the synchronous generator and indirectly reducing the abandoned wind volume of the wind turbine. The simulation is carried out on the MATLAB/SIMULINK platform. The results show that the presenting variable coefficient frequency modulation strategy could significant smooth the wind power fluctuation, and allow the reserve power of the doubly-fed wind turbine can fully engaged in frequency modulation which will reduces the frequency modulation pressure of the synchronous generator in the system.
Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/Caspase-1/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson’s Disease
Authors: Rui Wenjuan , Li Sheng , Xiao Hong , Xiao Ming , Shi Jingping 
Published: July 2020

Abstract

Background
Inflammasome-induced neuroinflammation is a major pathogenic mechanism underlying the degeneration of nigral dopaminergic neurons in Parkinson’s disease (PD). Baicalein is a flavonoid isolated from the traditional Chinese medicinal herbal Scutellaria baicalensis Georgi with known anti-inflammatory and neuroprotective efficacy in models of neurodegenerative diseases, including PD. However, its effects on inflammasome-induced neuroinflammation during PD remain unclear.

Methods
We used N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce PD-like pathology in mice. Behavioral assessments including the pole test, rotarod test, and open field test were conducted to evaluate the effects of baicalein on MPTP-induced motor dysfunction. The efficacies of baicalein against MPTP-induced dopaminergic neuron loss and glial cell activation in the substantia nigra compact were examined by immunohistochemistry, effects on proinflammatory cytokines by quantitative real-time PCR and enzyme-linked immunosorbent assay, and effects on inflammasome pathway activation by immunoblotting and flow cytometry.

Results
Administration of baicalein reversed MPTP-induced motor dysfunction, loss of dopaminergic neurons, and pro-inflammatory cytokine elevation. Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D-dependent pyroptosis. Additionally, baicalein inhibited the activation and proliferation of disease-associated proinflammatory microglia.

Conclusions
These findings suggest that baicalein can reverse MPTP-induced neuroinflammation in mice by suppressing NLRP3/caspase-1/gasdermin D pathway. Our study provides potential insight into the use of baicalein in PD therapy.
Smoothing Pairs Over Degenerate Calabi–Yau Varieties
Authors: Chan Kwokwai , Ma Ziming Nikolas 
Published: July 2020

Abstract
We apply the techniques developed in [2] to study smoothings of a pair $(X,\mathfrak{C}^*)$, where $\mathfrak{C}^*$ is a bounded perfect complex of locally free sheaves over a degenerate Calabi–Yau variety $X$. In particular, if $X$ is a projective Calabi–Yau variety admitting the structure of a toroidal crossing space and with the higher tangent sheaf $\mathcal{T}^1_X$ globally generated, and $\mathfrak{F}$ is a locally free sheaf over $X$, then we prove, using the results in [ 8], that the pair $(X,\mathfrak{F})$ is formally smoothable when $\textrm{Ext}^2(\mathfrak{F},\mathfrak{F})_0 = 0$ and $H^2(X,\mathcal{O}_X) = 0$.
The Impact of Maternal Human Immunodeficiency Virus Infection on the Burden of Respiratory Syncytial Virus Among Pregnant Women and Their Infants, Western Kenya
Authors: Nyawanda Bryan O , Otieno Nancy A , Otieno Michael O , Emukule Gideon O , Bigogo Godfrey , Onyango Clayton O , Lidechi Shirley , Nyaundi Jeremiah , Langley Gayle E , Widdowson Marc-Alain , Chaves Sandra S 
Published: July 2020

Abstract

Background
Respiratory syncytial virus (RSV) is an important cause of respiratory illness worldwide; however, burden data on mother–infant pairs remain sparse in sub-Saharan Africa, where human immunodeficiency virus (HIV) is prevalent. We evaluated the impact of maternal HIV infection on the burden of RSV among mothers and their infants in western Kenya.

Methods
We enrolled pregnant women (≤20 weeks’ gestation) and followed them and their newborns weekly for up to 3–6 months postpartum, to document cases of acute respiratory illness (ARI). Nasal/oropharyngeal swabs were collected and tested for RSV using polymerase chain reaction. Analyses were stratified by maternal HIV status and incidence was computed per 1000 person-months.

Results
Compared to RSV-negative ARI cases, RSV-positive cases were associated with cough, apnea, and hospitalization among infants. RSV incidence per 1000 person-months among mothers was 4.0 (95% confidence interval [CI], 3.2–4.4), and was twice that among the HIV-infected mothers (8.4 [95% CI, 5.7–12.0]) compared to the HIV-uninfected mothers (3.1 [95% CI, 2.3–4.0]). Among infants, incidence per 1000 person-months was 15.4 (95% CI, 12.5–18.8); incidence did not differ by HIV exposure or prematurity.

Conclusions
HIV infection may increase the risk of RSV illness among pregnant women. Future maternal RSV vaccines may have added benefit in areas with high HIV prevalence.
Hepatitis C Virus (HCV) Eradication With Interferon-Free Direct-Acting Antiviral-Based Therapy Results in KLRG1+ HCV-Specific Memory Natural Killer Cells
Authors: Wijaya Ratna S , Read Scott A , Selvamani Sakthi P , Schibeci Stephen , Azardaryany Mahmoud K , Ong Adrian , van der Poorten David , Lin Rita , Douglas Mark W , George Jacob , Ahlenstiel Golo 
Published: July 2020

Abstract
Direct acting antiviral therapies rapidly clear chronic hepatitis C virus (HCV) infection and restore natural killer (NK) cell function. We investigated NK-cell memory formation following HCV clearance by examining NK-cell phenotype and responses from control and chronic HCV patients before and after therapy following sustained virologic response at 12 weeks post therapy (SVR12). NK-cell phenotype at SVR12 differed significantly from paired pretreatment samples, with an increase in maturation markers CD16, CD57, and KLRG1. HCV patients possessed stronger cytotoxic responses against HCV-infected cells as compared to healthy controls; a response that further increased following SVR12. The antigen-specific response was mediated by KLRG1+ NK cells, as demonstrated by increased degranulation and proliferation in response to HCV antigen only. Our data suggest that KLRG1+ HCV-specific memory NK cells develop following viral infection, providing insight into their role in HCV clearance and relevance with regard to vaccine design.