bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDIDIKAN KARAKTER MELALUI PEMBELAJARAN DI KB DEWI SARTIKA DESA BATU MAK JAGE KABUPATEN SAMBAS
Authors: Suratman Bayu Bayu 
Published: February 2020

Abstrak: Tulisan ini mendeskripsikan pendidikan karakter melalui pembelajaran di KB Dewi Sartika Desa Batu Mak Jage Kecamatan Tebas Kabupaten Sambas Provinsi Kalimantan Barat. Berdasarkan penelitian yang penulis lakukan pendidikan karakter yang ditanamkan oleh guru berdasarkan sosial masyarakat dan kondisi lingkungan tempat tinggal siswa. Siswa yang ada di KB Dewi Sartika terdiri dari suku yaitu, Melayu dan Dayak. Penanaman nilai-nilai karakter oleh guru dilakukan melalui pembelajaran yang diberikan. Artikel ini ditulis secara deskriptif dan berangkat dari penelitian kualitatif yang penulis lakukan, berdasarkan pengamatan dan wawancara yang dilakukan kepada guru di KB Dewi Sartika Desa Batu Mak Jage.Kata Kunci: Pendidikan Karakter, KB Dewi Sartika Abstract: This paper describers character through learning at KB Dewi Sartika Batu Mak Jage Village, Tebas district, Sambas regency, west Kalimantan province. Based on research that the authors did, character education that was instilled by the teacher was based on the community’s social and environmental condition where the students lived. Student in KB Dewi Sartika consisof tribes namely, Malay and Dayak. Planting character values vy the teacher is done through learning that is given. This article was written descriptively and departed from the qualitative research that the author did, based on the equipment and interviews carried out the teacher at KB Dewi Sartika, Batu Mak Jage Village.Keywords: Character Education, KB Dewi Sartika
Pengembangan Kemandirian Anak Usia 5-6 Tahun di TK Dharmawanita Tunas Harapan
Authors: Silranti Malia 
Published: February 2020

This study was aimed at describing development of the independence of children aged 5-6 year in TK Dharmawanita Tunas Harapan kabupaten Pesisir Selatan. The research method is used a qualitative descriptive. Thedata were gained through conducting interviews, observation and documentation. The data were then analyzed using interactive model of data analysis from Miles and Huberman. The data was analyzed by using triangulation technique through collection data, reduction, display, and verification. From the result research showed that development of independence refers to the curiculum. The learning method used by the teacher in developing independence is the method of habituation, conversing, question answer, playing and giving assignments. But in planning it is not clerly described the development of children’s independence.
Acceptability and Appropriateness of a Perinatal Depression Preventive Group Intervention: A Qualitative Analysis
Authors: Diebold Alicia , Segovia Melissa , Johnson Jessica K. , Degillio Aria , Zakieh Dana , Park Hee Jin , Lim Kenneth , Tandon S. Darius 
Published: February 2020

Abstract
Background: Perinatal depression is a prevalent public health concern. Although preventive interventions exist, there is limited literature on the acceptability and appropriateness of these interventions, especially those delivered by paraprofessionals. The Mothers and Babies Program (MB) is a group-based perinatal depression preventive intervention delivered prenatally. A cluster-randomized controlled trial examined the acceptability, appropriateness, and effectiveness of MB delivered by mental health professionals compared to paraprofessional staff from home visiting programs.Methods: The full study enrolled 874 pregnant women. Fifty-three facilitators were trained and delivered the MB intervention to women in one of seven states in the United States. Semi-structured interviews were attempted with a randomly-selected subset of the full sample of pregnant women who received the MB intervention and with all facilitators. Specifically, interviews were conducted with 88 women who received the MB group intervention (45 in the paraprofessional-led arm and 43 in the mental health professional-led arm) and 46 women who facilitated the groups (27 home visiting staff and 19 mental health professionals). Interviews were conducted over the phone in English or Spanish and audio recorded. The recordings were translated into English, as needed, and transcribed. Thematic analysis was conducted using NVIVO to identify key themes related to intervention acceptability and appropriateness. Similarities and differences between study arms were explored.Results: Clients and facilitators found the MB content and group format acceptable. Challenges included maintaining group attendance, transportation issues, and managing group discussion. Overall, facilitators found the intervention appropriate for pregnant clients with some challenges presented for clients in crisis situations, experiencing housing instability, and with literacy and learning challenges. Participants provided suggestions for improvement, both for the course content and implementation. There were no significant differences found between study arms. Conclusions: Overall, clients and facilitators enjoyed MB irrespective of study arm, and facilitators found the intervention appropriate for the population. These findings add to the qualitative literature on perinatal depression preventive interventions, specifically those delivered by paraprofessionals. Trial Registration: This trial is registered on ClinicalTrials.gov (Initial post: December 1, 2016; identifier: NCT02979444; https://clinicaltrials.gov/ct2/show/NCT02979444).
A large-scale comparative study of isoform expressions measured on four platforms
Authors: Zhang Wei , Petegrosso Raphael , Chang Jae Woong , Sun Jiao , Yong Jeongsik , Chien Jeremy , Kuang Rui 
Published: February 2020

Abstract
Background: Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is necessary to accurately measure isoform expressions as well as gene expressions. While previous studies have demonstrated the strong agreement between mRNA-sequencing (RNA-seq) and array-based gene and/or isoform quantification platforms (Microarray gene expression and Exon-array), the more recently developed NanoString platform has not been systematically evaluated and compared, especially in large-scale studies across different cancer domains.
Results: In this paper, we present a large-scale comparative study among RNA-seq, NanoString, array-based, and RT-qPCR platforms using 46 cancer cell lines across different cancer types. The goal is to understand and evaluate the calibers of the platforms for measuring gene and isoform expressions in cancer studies. We first performed NanoString experiments on 59 cancer cell lines with {\color{red}404} custom-designed probes for measuring the expressions of 478 isoforms in 155 genes, and additional RT-qPCR experiments for a subset of the measured isoforms in 13 cell lines. We then combined the data with the matched RNA-seq, Exon-array, and Microarray data of 46 of the 59 cell lines for the comparative analysis.
Conclusion: In the comparisons of the platforms for measuring the expressions at both isoform and gene levels, we found that (1) the agreement on isoform expressions is lower than the agreement on gene expressions across the four platforms; (2) NanoString and Exon-array are not consistent on isoform quantification even though both techniques are based on hybridization reactions; (3) RT-qPCR experiments are more consistent with RNA-seq and Exon-array than NanoString in isoform quantification; (4) different RNA-seq isoform quantification methods show varying estimation results, and among the methods, Net-RSTQ and eXpress are more consistent across the platforms; and (5) RNA-seq has the best overall consistency with the other platforms on gene expression quantification.
Canine serological survey and dog culling ant its relationship with Human ­Visceral leishmaniasis in an endemic urban area.
Authors: Bermudi Patricia Marques Moralejo , Costa Danielle Nunes Carneiro Castro , Nunes Caris Maroni , Tolezano Jose Eduardo , Hiramoto Roberto Mitsuyoshi , Rodas Lilian Aparecida Colebrusco , Cipriano Rafael Silva , Blangiardo Marta , Chiaravalloti-Neto Francisco 
Published: February 2020

Abstract
Background: Visceral leishmaniasis is an important but neglected disease that is spreading and is highly lethal when left untreated. This study sought to measure the Leishmania infantum seroprevalence in dogs, the coverage of its control activities (identification of the canine reservoir by serological survey, dog culling and insecticide spraying) and to evaluate its relationship with the occurrence of the disease in humans in the municipalities of Araçatuba and Birigui, state of São Paulo, Brazil. Methods: Information from 2006 to 2015 was georeferenced for each municipality and modeling was performed for the two municipalities together. To do this, latent Gaussian Bayesian models with the incorporation of a spatio-temporal structure and Poisson distribution were used. The Besag-York-Mollie models were applied for random spatial effects, as also were autoregressive models of order 1 for random temporal effects. The modeling was performed using the INLA (Integrated Nested Laplace Approximations) deterministic approach, considering both the numbers of cases as well as the coverage paired year by year and lagged at one and two years. Results: Control activity coverage was observed to be generally low. The behavior of the temporal tendency in the human disease presented distinct patterns in the two municipalities, however, in both the tendency was to decline. The canine serological survey presented as a protective factor only in the two-year lag model. Conclusions: The canine serological coverage, even at low intensity, carried out jointly with the culling of the positive dogs, suggested a decreasing effect on the occurrence of the disease in humans, whose effects would be seen two years after it was carried out.
A Randomized Controlled Trial of an Educational Intervention to Promote Oral and Dental Health of Patients with Type 2 Diabetes Mellitus
Authors: Mallekmahmoodi Maryam , Shamsi Mohsen , Roozbahani Nasrin , Moradzadeh Rahmatollah 
Published: February 2020

Abstract
Background: Diabetes is the most prevalent disease resulted from metabolic disorders. This study aimed to investigate the effect of training based on health belief model (HBM) on oral hygiene-related behaviors in patients with type 2 diabetes mellitus.
Methods: This study was conducted as an educational randomized controlled trial (single blind) on 120 patients with type 2 diabetes referring to a diabetes clinic selected through systematic sampling, who were assigned to two groups of control (N=60) and intervention (N=60). The data collection tool was a valid and reliable questionnaire based on HBM which was completed by both groups before the intervention. Then, the intervention group received 4 sessions of educational program based on HBM in one month, and the same questionnaire was completed again after 3 months and the data were analyzed through SPSS version 20 software with inferential statistics, t-test, paired t-tests, Chi square, Mann-Whitney test, and Wilcoxon test analysis.
Results: Three months after the intervention, awareness of the patients and perceived susceptibility, benefits, self-efficacy, internal cue to action, and performance in oral and dental hygiene-related behaviors had a significant increase in the intervention group (p<0.05). So that the performance of oral and dental hygiene in the intervention group increased from 2.16 ± 0.71 to 3.25 ± 0.49 (p=0.001) after the education.
Conclusion: Our results suggest that training patients with diabetes based on HBM as well as through active follow-up can enhance their skills in oral and dental hygiene-related behaviors. Controlling, monitoring and follow-up during the program are also recommended.
Experiences, views and needs of first-time fathers in pregnancy related care: a qualitative study in south-east Nigeria.
Authors: Onyeze-Joe Chiemeka , Godin Isabelle 
Published: February 2020

Abstract
Background
Given the relevance of paternal involvement in maternal care, there is a need to prepare first-time fathers to participate in pregnancy and childbirth actively. This study explores the experiences and needs of first-time fathers and the influence of these on their involvement during pregnancy and childbirth in Nigeria.
Methods
A descriptive qualitative study was conducted. Semi-structured interviews with 50 men recruited from rural and urban workplaces, hospitals, and markets, generated data used to explore the experiences, views and needs of first-time fathers’ in pregnancy-related care in south-east Nigeria. All data were transcribed and analysed using thematic analysis.
Results
Six major themes were identified: gender roles, antenatal involvement, care costs and delivery choices, need to be informed, dealing with emotions, and dealing with the delivery day. A key finding was that inexperience, cultural beliefs and perceptions of gender norms greatly influenced the support provided by first-time fathers to their spouses, and the support they received from their social support networks. Two primary needs were identified: need to be informed and the need to know about the cost of care in health settings. First-time fathers acknowledged the role of information on their decision making and final choices.
Conclusion
Findings reveal the influence of gender norms, beliefs, and social support on first-time fathers’ involvement in pregnancy and childbirth. This study also highlights the urgent need to provide informational support for first-time fathers and presents insights into what hospitals can do to achieve this need.
Keywords: male involvement, first-time fathers, pregnancy, qualitative, Nigeria
Strategies to reach and motivate migrant communities at high risk for TB to participate in a latent tuberculosis infection screening program: a community-engaged mixed methods study among Eritreans
Authors: Spruijt Ineke , Haile Dawit Tesfay , Erkens Connie , Hof Susan van den , Goosen Simone , Kate Andrea ten , Teshome Hewan , Karels Marja , Koenders Marga , Suurmond Jeanine 
Published: February 2020

Abstract
Background: In the Netherlands, migrant populations with a high tuberculosis (TB) incidence are an important target group for TB prevention. However, there is a lack of insight in effective community-engaged strategies to reach and motivate these migrants to participate in latent TB infection (LTBI) screening and treatment programs.
Methods: In cocreation with Eritrean key figures and TB staff, we designed and executed six strategies to reach and motivate Eritrean communities to participate in LTBI programs, in five regions in the Netherlands. We registered participation in LTBI education and screening, and LTBI treatment uptake and completion. We used semi-structured group and individual interviews with Eritrean participants, key figures, and TB staff to identify facilitators and barriers.
Results: Uptake of LTBI education (13% - 75%) and consequent screening (10% - 124%) varied between strategies. LTBI screening uptake >100% resulted from educated participants motivating others to participate in screening. Two strategies, using face-to-face promotion and targeting smaller groups, were the most successful. The program resulted in high LTBI treatment initiation and completion (both 97%). Reported program barriers included: competing priorities in the target group, perceived good health, poor risk perception, and scepticism towards the program purpose. TB staff perceived the program as useful but demanding in terms of human resources.
Conclusions: Eritrean migrant communities can be successfully reached and motivated for LTBI screening and treatment programs, when sufficient (human) resources are in place and community members, well-connected to and trusted by the community, are engaged in the design and execution of the program.
Effects of Ultrasound-Guided Paravertebral Block on MMP-9 and Postoperative Pain in Patients Undergoing VATS Lobectomy: A Randomized, Controlled Clinical Trial
Authors: Chu Haichen , Dong He , Wang Yongjie , Niu Zejun 
Published: February 2020

Abstract
Background: Local anesthesia can reduce the response to surgical stress and decrease the consumption of opioids, which may reduce immunosuppression and potentially delay postoperative tumor recurrence. We compared paravertebral block(PVB) combined with general anesthesia(GA) and general anesthesia regarding their effects on matrix metalloproteinase-9 (MMP-9) and postoperative pain after video-assisted thoracoscopic surgery(VATS) lobectomy.
Methods: 54 patients undergoing elective VATS lobectomy at a single tertiary care, teaching hospital located in Qingdao between May 2 2018 and Sep 28 2018 were randomised by computer to either paravertebral block combined with general anesthesia or general anesthesia. The primary outcome was pain scores during postoperative 48h. The secondary outcome were plasma concentrations of MMP-9, complications, and duration of postoperative hospital stay.
Results: 75 were enrolled to the study, of whom 21 were excluded before surgery. We analyzed lobectomy patients undergoing paravertebral block combined with general anesthesia (n=25) or general anesthesia (n=24). Both groups were similar regarding baseline characteristics. Pain scores were lower at 4h and 24h in PVB/GA group, compared with GA group (2.53±0.83 vs 3.4±0.91; 2.2±0.94 vs 3.0±0.93, respectively, P <0.05). There were no difference at 1h and 48h between groups. Patients in the PVB/GA group showed a greater decrease in plasma MMP-9 level at T1 and T2 after VATS lobectomy ( P <0.05). Postoperative complications and length of stay did not differ by anesthetic technique.
Conclusions: The paravertebral block/general anesthesia can provide statistically better pain relief and attenuate MMP-9 response to surgery and after VATS lobectomy. This technique may be beneficial for patients to recover rapidly after lung surgery and reduce postoperative tumor recurrence.
Overexpression Of Mig-6 In Cartilage Induces An Osteoarthritis-like Phenotype In Mice
Authors: Bellini Melina , Pest Michael Andrew , Rodrigues Manuela Miranda , Qin Ling , Jeong Jae-Wook , Beier Frank 
Published: February 2020

Abstract
Background: Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the Epidermal Growth Factor Receptor (EGFR). Cartilage-specific Mig-6 knockout (KO) mice display increased EGFR signaling, an anabolic buildup of articular cartilage and formation of chondro-osseous nodules. Since our understanding of the EGFR/Mig-6 network in cartilage remains incomplete, we characterized mice with cartilage-specific overexpression of Mig-6 in this study.
Methods : Utilizing knee joints from cartilage-specific Mig-6 overexpressing ( Mig- 6over/over ) mice (at multiple time points), we evaluated the articular cartilage using histology, immunohistochemical staining and semi-quantitative OARSI scoring at multiple ages. MicroCT analysis was employed to examine skeletal morphometry, body composition, and bone mineral density.
Results: Our data show that cartilage-specific Mig-6 overexpression did not cause any major developmental abnormalities in articular cartilage, although Mig-6 over/over mice have slightly shorter long bones compared to the control group. Moreover, there was no significant difference in bone mineral density and body composition in any of the groups. However, our results indicate that Mig-6 over/over male mice show accelerated cartilage degeneration at 12 and 18 months of age. Immunohistochemistry for SOX9 demonstrated that the number of positively stained cells in Mig-6 over/over mice decreased relative to controls. Immunostaining for MMP13 staining is increased in areas of cartilage degeneration in Mig-6 over/over mice. Moreover, staining for phospho-EGFR (Tyr-1173) and lubricin (PRG4) was decreased in the articular cartilage of Mig-6 over/over mice.
Conclusion: Overexpression of Mig-6 in articular cartilage causes no major developmental phenotype; however these mice develop earlier OA during aging. These data demonstrate that Mig-6/EGFR pathways is critical for joint homeostasis and might present a promising therapeutic target for OA.
Identifying Latent Variables in Dynamic Bayesian Networks with Bootstrapping Applied to Type 2 Diabetes Complication Prediction
Authors: Yousefi Leila , Al-Luhaybi Mashael , Sacchi Lucia , Chiovato Luca , Tucker Allan 
Published: February 2020

Abstract
Background: Type 2 Diabetes is a chronic disease with an onset that is commonly associated with multiple life-threatening comorbidities (complications). Early prediction of diabetic complications while discovering the behaviour of associated aggressive risk factors can reduce the patients’ suﬀering time. Therefore, models of the time series diabetic data (which are often imbalanced, incomplete and involve complex interactions) are needed to better manage diabetic complications.Aims: The aim of this work is to both deals with imbalanced clinical data using a bootstrapping approach, whilst determining the precise position of latent variables within probabilistic networks generated from the observations. The main motivation behind this paper is to stratify patient groups by means of latent variables to discover how complications in diabetes interact.Methods: We propose a time series bootstrapping method for building Dynamic Bayesian Networks that includes hidden/latent variables, applied to a case for predicting T2DM complications. A combination of the IC* algorithm on time series bootstrapped data is utilised to identify the latent variables within a Bayesian model. Then, an exploration of inference methods assessed the inﬂuences of these latent variables.Results: Our promising ﬁndings show how this targeted use of latent variables improves prediction accuracy, speciﬁcity, and sensitivity over standard approaches as well as aiding the understanding of relationships between these latent variables and disease complications/risk factors. The contribution of this paper compared to the previous papers in which time series bootstrapping is used for re-balancing the data and providing conﬁdence in the prediction results.Conclusion: Our results showed that our re-balancing approach by the use of Time Series bootstrapping method for an unequal number of time series visits demonstrated an improvement in the prediction performance. Additionally, the most highlighted contribution of this paper gained insight by interpreting the latent states (looking at the associated distributions of complications), which led to a better understanding of risk factors and patient-speciﬁc interventions: here the fact that the latent variable demonstrated that a patient falls into a sub-group that is hypertensive but not suﬀering from retinopathy.