bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTRATEGIA DIDÁCTICA DE ESTIMULACIÓN TEMPRANA PARA El DESARROLLO DE LA CORPOREIDAD EN LOS NIÑOS DE LA INSTITUCIÓN EDUCATIVA INICIAL N° 122: CORAZÓN DE JESÚS, DISTRITO DE LAGUNAS, CHICLAYO
Authors: Sánchez Roalcaba Magally Verónica , Cabrera Cabrera Xiomara 
Published: October 2020

La investigación aborda los resultados de una tesis de maestría. Revela insuficiencias en la actividad física motora de los niños, lo que limita el desarrollo de su corporeidad, que deviene en el problema científico. En tal sentido, se formula como objetivo: Elaboración de una estrategia didáctica de estimulación temprana para el desarrollo de la corporeidad en los niños de la Institución Educativa Inicial Nº 122: Corazón de Jesús de Lagunas, Chiclayo, Lambayeque. La investigación revela la necesidad de significar el proceso de construcción biopsicosocial en los niños de educación inicial, desde la dinámica, teniendo en cuenta la relación entre la intencionalidad formativa y la sistematización interactiva en la actividad física. El aporte práctico se estructura en etapas que introduce en la práctica educativa, revelando trasformaciones en el actuar de los estudiantes de 3 a 5 años a través de la ejemplificación parcial de la misma utilizando jugos de roles didácticos. Se corrobora el aporte a través de consulta de expertos especialistas e educación inicial. Se emplearon además métodos del nivel teórico, empírico y estadístico para corroborar las etapas de la investigación.Palabras clave: Desarrollo de la corporeidad; actividad motora; habilidades corpóreas; prácticas motrices.
ESTRATEGIA MOTIVACIONAL PARA LA MEJORA DEL APRENDIZAJE SIGNIFICATIVO EN ALUMNOS DE SECUNDARIA DE LA I.E. SARA A. BULLÓN
Authors: Veliz Palacios Sonia Mercedes , Callejas Torres Juan Carlos 
Published: October 2020

En el presente trabajo se hace un estudio de la inadecuada intencionalidad motivacional, limitante del aprendizaje significativo en I.E SARA A. BULLÓN en los estudiantes del segundo año “B” en la asignatura de Persona, Familia y Relaciones Humanas (PFRH). Se investigan las causas que pueden originar el problema planteado, pudiéndose constatar que es necesario profundizar en el estudio del objeto de la investigación, el proceso motivacional. La presente Investigación tuvo como objetivo Elaborar una estrategia motivacional, basada en la dinámica del proceso, para la mejora del aprendizaje significativo de las alumnas del segundo año “B” de Educación Secundaria en el área de PFRH de la I.E. Sara A. Bullón de Lambayeque. Su importancia radica el impacto que tiene al mejoramiento del aprendizaje significativo en los estudiantes a través de la motivación. La muestra estuvo conformada por estudiantes del segundo de secundaria, así como el profesor de la asignatura y el jefe de área de la misma, siendo la investigación no experimental, descriptiva y propositiva. Para el análisis de resultado, se utilizó el programa estadístico SPSS, encontrando los siguientes resultados: existe bajo nivel en cuanto a la aptitud y percepción de los estudiantes para efectuar un aprendizaje significativo, pobre adquisición e integración de conocimientos, pensamiento alejado a dar solución a la realidad.
Infecciones en el paciente inmunodeprimido, a propósito de un caso de Esclerosis Sistémica
Authors: Armijos Alex , Villafuerte Silvana , Carrero Castillo Yenndy Nayghit 
Published: October 2020

Introducción: La esclerosis es una enfermedad crónica, degenerativa, incapacitante y letal, que afecta a miles de personas. Su presentación clínica variable la ha convertido en un desafío diagnóstico, retrasando el tratamiento oportuno. En Ecuador no se conocen datos estadísticos exactos del número de pacientes con esta patología. El uso de terapias de inmunosupresión para tratar esta enfermedad ha hecho del paciente un blanco fácil para infecciones por patógenos oportunistas que muchas veces pasan desapercibidos. La infección por tuberculosis es de alta preocupación en estos pacientes, sobre todo cuando se administran terapias con corticoides más inmunosupresores por tiempo prolongado.
Objetivo: Describir los efectos del uso prolongado de inmunosupresores y la susceptibilidad a infecciones por patógenos oportunistas.
Material y métodos: Estudio descriptivo retrospectivo, presentación de caso clínico de una paciente femenina diagnosticada con esclerosis múltiple con tratamiento inmunosupresor prolongado que es diagnosticada de manera fortuita con tuberculosis.
Resultados: Se presenta un caso de una paciente femenina de 46 años, con antecedentes de Esclerosis Sistémica en tratamiento hace 18 años con prednisona 5 y 10 mg, micofenolato mofetil de 500 mg cada día, con antecedentes de cáncer, que es ingresada después de presentar sintomatología variada con tratamiento sin efectividad. Se realiza Tomografía de tórax que evidencia lesión quística cavitada en campo pulmonar izquierdo, con aparente infiltrado, Función renal, electrolitos y gasometría arterial dentro de parámetros normales y BAAR de esputo resultado positivo, por lo cual se inicia tratamiento antifimico.
Conclusiones: Es de gran importancia que todos los profesionales de la salud que atienden a este tipo de pacientes tengan el conocimiento de las posibles complicaciones y el riesgo de infección latente propia de la enfermedad o por las terapias de inmunodepresión de manera prolongada. Se debe enfatizar en la realización de estrategias y protocolos para el correcto seguimiento de pacientes dentro del Sistema Nacional de Salud.
Tecnologías emergentes con aplicación en Salud: desarrollo de una plataforma integrada para la eva-luación de factores de riesgo, diagnóstico, tratamiento, pronóstico y geolocalización en Pandemia Co-vid- 19 por SARS-Cov-2
Authors: Leiva Suero Lizette Elena , Proaño Alulema Ricardo Xavier , Chicaiza Tayupanta Jesús Onorato , Recalde Navarrete Ricardo Javier , Hernández Navarro Elena Vicenta 
Published: October 2020

Introducción: Las denominadas tecnologías emergentes o tecnologías convergentes, son términos usados para señalar la emergencia y convergencia de nuevas tecnologías, respectivamente, con potencial de demostrarse como tecnologías disruptivas muestran un gran potencial de aplicación en Salud y pudieran representar un valioso recurso en el control de la pandemia Covid 19.
Objetivos: Revisar la mejor evidencia médica publicada sobre el empleo de tecnologías emergentes en Salud y aplicar estas experiencias en el desarrollo de una plataforma integrada para la evaluación de factores de riesgo diagnóstico, tratamiento, pronóstico y geolocalización de pacientes en la pandemia Covid 19.
Material y Métodos: Se realizó una búsqueda sistemática en las bases de datos PubMed, ProQuest, Embase, Redalyc, Ovid, Medline, DynaMed y ClinicalKey, EMBASE, LILACS durante el periodo 2015-2020 en el contexto internacional, regional y local.
Resultados: La revisión sistemática de artículos aportó un total de 62 registros, de los cuales 21 eran elegibles; de estos, 8 fueron relevantes al objeto de esta revisión.
Conclusiones: La aplicación de las tecnologías emergentes para el desarrollo de plataformas integradas con fines, diagnósticos, terapéuticos, pronósticos y de geolocalización en condiciones de pandemia por Covid 19, permite garantizar la atención en Salud en condiciones de aislamiento y perfeccionar la integración de las funciones sustantivas de la Educación Superior en Ciencias de la Salud.
Theoretical Foundations of Education: contributions of the Psychology of Mathematics Education of the Early Years of Elementary School L
Authors: Pereira Carlos Luis , Pereira Marcia Regina Santana 
Published: October 2020

The central scope of this research addresses the Psychology of Mathematics Education for professionals with a degree in Pedagogy courses, focusing on teachers who exercise the teaching of mathematics teaching in the early years of elementary school I. This article analyzes and presents the potentialities and contributions of this theoretical field of knowledge in the teaching-learning process of Mathematics. Education aiming at improvements of the Brazilian student in the external evaluations of the Brazil Test published by the SAEB of 2017 and 2019, as well as the pedagogical practice between teacher-student-knowledge. It was justified the insufficient proficiency in mathematics of Brazilian students of about 70%, as well as the reduced number of scientific productions on the theme of this article. The objective of this study was to present contributions of the Psychology of Mathematics Education in the early years of elementary school I. On the methodological path, it was characterized within the qualitative approach and in the procedures of bibliographic research. Among the main results were the discourses of the interviewed subjects pointing out the potentiality of the theoretical basis of Psychology of Mathematics Education in their pedagogical knowledge/doing. It was found that the psychological, cognitive and affective-social dimension have implications for students' learning. It concludes an emergence of a further discussion of this field of knowledge in the degree of pedagogy courses in Brazil to increase the quality of pedagogical intervention of pedagogue teachers in mathematics classes, aiming to increase the quality teaching-learning process of mathematics in the early years and the results of institutional and large-scale evaluations.
Ensemble Machine Learning Approach Improves Predicted Spatial Variation of Surface Soil Organic Carbon Stocks in Data-Limited Northern Circumpolar Region
Authors: Mishra Umakant , Gautam Sagar , Riley William J. , Hoffman Forrest M. 
Published: October 2020

Various approaches of differing mathematical complexities are being applied for spatial prediction of soil properties. Regression kriging is a widely used hybrid approach of spatial variation that combines correlation between soil properties and environmental factors with spatial autocorrelation between soil observations. In this study, we compared four machine learning approaches (gradient boosting machine, multinarrative adaptive regression spline, random forest, and support vector machine) with regression kriging to predict the spatial variation of surface (0–30 cm) soil organic carbon (SOC) stocks at 250-m spatial resolution across the northern circumpolar permafrost region. We combined 2,374 soil profile observations (calibration datasets) with georeferenced datasets of environmental factors (climate, topography, land cover, bedrock geology, and soil types) to predict the spatial variation of surface SOC stocks. We evaluated the prediction accuracy at randomly selected sites (validation datasets) across the study area. We found that different techniques inferred different numbers of environmental factors and their relative importance for prediction of SOC stocks. Regression kriging produced lower prediction errors in comparison to multinarrative adaptive regression spline and support vector machine, and comparable prediction accuracy to gradient boosting machine and random forest. However, the ensemble median prediction of SOC stocks obtained from all four machine learning techniques showed highest prediction accuracy. Although the use of different approaches in spatial prediction of soil properties will depend on the availability of soil and environmental datasets and computational resources, we conclude that the ensemble median prediction obtained from multiple machine learning approaches provides greater spatial details and produces the highest prediction accuracy. Thus an ensemble prediction approach can be a better choice than any single prediction technique for predicting the spatial variation of SOC stocks.
Medical Humanities : A Novel Approach to Medicine for Washington County, Utah
Authors: Manuele Rachel 
Published: October 2020

To broaden and enrich physician education, the humanities have been introduced into medical school curricula through literature, history, art, and even music. Current medical culture necessitates and even encourages emotional detachment from healthcare providers, but the humanities provide a methodology to bridge that oft-lamented gap between patient and physician. Closing this gap will break down barriers that impede the delivery of outstanding healthcare. The merging of medical humanities in physician education and practice provides not only a methodology but a culture that can be incorporated into the healthcare system. Adopting this culture in Washington County, Utah, could assist in bridging the gap, greatly benefitting citizens and healthcare providers alike. This research project, which includes interviews with members of the St. George community and the University of Utah, suggests the benefits an interdisciplinary approach can have for Washington County in its hospitals and clinics as well as its undergraduate and medical school curricula.
Seletalisib for Activated PI3Kδ Syndromes: Open-Label Phase 1b and Extension Studies
Authors: Diaz Nieves , Juarez Maria , Cancrini Caterina , Heeg Maximilian , Soler-Palacín Pere , Payne Andrew , Johnston Geoffrey I. , Helmer Eric , Cain Dionne , Mann Joanne , Yuill Daisy , Conti Francesca , Di Cesare Silvia , Ehl Stephan , Garcia-Prat Marina , Maccari Maria Elena , Martín-Nalda Andrea , Martínez-Gallo Mónica , Moshous Despina , Santilli Veronica , Semeraro Michaela , Simonetti Alessandra , Suarez Felipe , Cavazzana Marina , Kracker Sven 
Published: October 2020

Abstract
Mutations in two genes can result in activated PI3Kδ syndrome (APDS), a rare immunodeficiency disease with limited therapeutic options. Seletalisib, a potent, selective PI3Kδ inhibitor, was evaluated in patients with APDS1 and APDS2. In the phase 1b study (European Clinical Trials Database 2015-002900-10) patients with genetic and clinical confirmation of APDS1 or APDS2 received 15–25 mg/d seletalisib for 12 wk. Patients could enter an extension study (European Clinical Trials Database 2015-005541). Primary endpoints were safety and tolerability, with exploratory efficacy and immunology endpoints. Seven patients (median age 15 years; APDS1 n = 3; APDS2 n = 4) received seletalisib; five completed the phase 1b study. For the extension study, four patients entered, one withdrew consent (week 24), three completed ≥84 wk of treatment. In the phase 1b study, patients had improved peripheral lymphadenopathy (n = 2), lung function (n = 1), thrombocyte counts (n = 1), and chronic enteropathy (n = 1). Overall, effects were maintained in the extension. In the phase 1b study, percentages of transitional B cells decreased, naive B cells increased, and senescent CD8 T cells decreased (human cells); effects were generally maintained in the extension. Seletalisib-related adverse events occurred in four of seven patients (phase 1b study: hepatic enzyme increased, dizziness, aphthous ulcer, arthralgia, arthritis, increased appetite, increased weight, restlessness, tendon disorder, and potential drug-induced liver injury) and one of four patients had adverse events in the extension (aphthous ulcer). Serious adverse events occurred in three of seven patients (phase 1b study: hospitalization, colitis, and potential drug-induced liver injury) and one of four patients had adverse events in the extension (stomatitis). Patients with APDS receiving seletalisib had improvements in variable clinical and immunological features, and a favorable risk–benefit profile was maintained for ≤96 wk.
Salivary detection of high-risk human papillomavirus 16 in oral squamous cell carcinoma using polymerase chain reaction in the South Indian population
Authors: Krishnappa Soujanya L. , David Chaya M. , Ramnarayan B. K. , Kanaparthi Alekhya , Krishnappa Suprith L. , Dukkireddy Divya 
Published: October 2020

Introduction:
Human papilloma virus (HPV) has been associated with oral squamous cell carcinoma (OSCC) as a potential carcinogen. There are several types of HPV, of which type 16 has been strongly implicated in carcinogenesis. HPV16 in saliva can potentially facilitate early detection of subclinical cases that may warrant further diagnosis, monitoring and intervention.

Aim:
The aim of this study was to evaluate the presence of HPV 16 in saliva and lesional tissue of OSCC and to determine the use of saliva as an alternative non invasive diagnostic tool in HPV16 identification.

Materials and methods:
30 cases of Histopathologically confirmed OSCC with HPV positive on ELISA were taken up for the study. The tumour tissue and saliva sample of each patient were obtained to detect the presence of specific HPV16 genotype by polymerase chain reaction (PCR). The data was subjected to statistical analysis using Student t-test.

Results:
In our study we found 28/30, 26/30 positive for HPV 16 in tissue and saliva samples respectively on PCR analysis. The P value was statistically significant (0.00).

Conclusion:
The study revealed significant prevalence of HPV 16 among both tissue and salivary specimens of OSCC patients in south Indian population. Though, the yielded content was relatively less in saliva, it can be concluded that, saliva being a non invasive tool proved to be as useful as tissue specimen and can be used as an alternative indicator of HPV16 positivity in OSCC.
Proposta de framework para o processo de gestão de Riscos no setor Público (PROGERIS)
Authors: Oliveira Thiago , Santos Pablo Luan Bezerra , Medeiros Júnior Josué Vitor , Gurgel André Morais , Silva Bruno José Pereira 
Published: October 2020

Com a intensificação da Gestão de Riscos (GR) no setor público, observa-se a necessidade em se adaptar práticas de modelos reconhecidos em GR para realidade das instituições públicas. O presente trabalho objetiva apresentar a aplicação e os resultados de uma proposta de framework para o Processo de Gestão de Riscos em uma Instituição Federal de Ensino Superior. Esse trabalho é qualitativo e aplicado, sua abordagem metodológica é o estudo de caso e para a coleta dos dados foi adotada a estratégia da triangulação e do grupo focal, observação participante e questionário semiestruturado. Do mesmo modo, essa pesquisa também é descritiva do ponto de vista de seus resultados, sendo os dados analisados na ótica da Análise de Discurso e Análise de Conteúdo. Por fim, os resultados apresentam o detalhamento da aplicação do framework na instituição com o desdobramento de dez etapas sustentadas pela literatura e perspectiva da equipe, demonstrando ainda que o framework trouxe ganhos em relação ao cumprimento dos objetivos organizacionais quanto ao gerenciamento de riscos e aumento da eficiência dos processos.
A formação leitora entre livros e redes sociais: os sentidos produzidos por alunos da educação básica sobre a biblioteca pública da sua cidade
Authors: Andrade Francisco Ari de , Paixão Erinelda da Costa 
Published: October 2020

Este artigo buscou apreender o sentido que os estudantes da educação básica estão construindo da biblioteca de sua cidade. O esforço consistiu em investigar a significação que eles atribuem à biblioteca pública municipal no tocante à sua funcionalidade, pondo, assim, em evidência, a relação da instituição com o processo de ensino-aprendizagem. Tal esforço foi empreendido e guiado pela abordagem da história cultural, com base na semiótica de Roger Chartier (2002). A pesquisa, de cunho quanti-qualitativo, foi desenvolvida no interstício de 2016-2017 nas dependências da Biblioteca Pública Municipal Capistrano de Abreu, da cidade Maranguape – Ceará, e consistiu-se em três etapas. Na primeira, com enfoque bibliográfico, foram feitas as leituras subjacentes à temática; na segunda, utilizou-se como instrumento o questionário, com questões objetivas de múltipla escolha, aplicado aos sujeitos da pesquisa; na terceira etapa, a tabulação dos dados e a elaboração de gráficos, para em seguida analisar a partir de um olhar compreensivo, o sentido que os estudantes apontam acerca da biblioteca em sua relação com o saber. Os resultados demonstram que a biblioteca pública é percebida pelos estudantes como sendo um suporte para a ação pedagógica da escola em seu processo de ensino-aprendizagem, haja vista que o sentido construído sobre a instituição se confunde com as atividades escolares nas quais o aluno é solicitado a resolver.
Evapotranspiration over agroforestry sites in Germany
Authors: Markwitz Christian , Knohl Alexander , Siebicke Lukas 
Published: October 2020

Abstract. In the past few years, the interest in growing crops and trees for bioenergy production has increased. One agricultural practice is the mixed cultivation of fast-growing trees and annual crops or perennial grasslands on the same piece of land, which is referred to as one type of agroforestry (AF). The inclusion of tree strips into the agricultural landscape has been shown – on the one hand – to lead to reduced wind speeds and higher carbon sequestration above ground and in the soil. On the other hand, concerns have been raised about increased water losses to the atmosphere via evapotranspiration (ET). Therefore, we hypothesise that short rotation coppice agroforestry systems have higher water losses to the atmosphere via ET compared to monoculture (MC) agriculture without trees. In order to test the hypothesis, the main objective was to measure the actual evapotranspiration of five AF systems in Germany and compare those to five monoculture systems in the close vicinity of the AF systems. We measured actual ET at five AF sites in direct comparison to five monoculture sites in northern Germany in 2016 and 2017. We used an eddy covariance energy balance (ECEB) set-up and a low-cost eddy covariance (EC-LC) set-up to measure actual ET over each AF and each MC system. We conducted direct eddy covariance (EC) measurement campaigns with approximately 4 weeks' duration for method validation. Results from the short-term measurement campaigns showed a high agreement between ETEC-LC and ETEC, indicated by slopes of a linear regression analysis between 0.86 and 1.3 (R2 between 0.7 and 0.94) across sites. Root mean square errors of LEEC-LC vs. LEEC (where LE is the latent heat flux) were half as small as LEECEB vs. LEEC, indicating a superior agreement of the EC-LC set-up with the EC set-up compared to the ECEB set-up. With respect to the annual sums of ET over AF and MC, we observed small differences between the two land uses. We interpret this as being an effect of compensating the small-scale differences in ET next to and in between the tree strips for ET measurements on the system scale. Most likely, the differences in ET rates next to and in between the tree strips are of the same order of magnitude, but of the opposite sign, and compensate each other throughout the year. Differences between annual sums of ET from the two methods were of the same order of magnitude as differences between the two land uses. Compared to the effect of land use and different methods on ET, we found larger mean evapotranspiration indices (∑ET/∑P) across sites for a drier than normal year (2016) compared to a wet year (2017). This indicates that we were able to detect differences in ET due to different ambient conditions with the applied methods, rather than the potentially small effect of AF on ET. We conclude that agroforestry has not resulted in an increased water loss to the atmosphere, indicating that agroforestry in Germany can be a land-use alternative to monoculture agriculture without trees.