bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational imaging with low-order OAM beams at microwave frequencies
Authors: Liu Kang , Cheng Yongqiang , Liu Hongyan , Wang Hongqiang 
Published: July 2020

AbstractWith the distinguished wavefront characteristics of vortex electromagnetic wave carrying orbital angular momentum (OAM), the OAM beams have been exploited for radar imaging in recent years. In this paper, the computational imaging model is built using OAM wave, which enables the target reconstruction with limited measurements. The measurement matrix is designed, and the target reconstruction method is proposed in the Cartesian coordinate. Simulation results indicate that the proposed computational imaging approach is robust against noise influence. Furthermore, the outdoor experiments are carried out, for the first time, to validate the super-resolution imaging ability of this novel technique. Experimental results show good agreement with theoretical analyses. This work can advance the development of OAM-based sensing technology.
Nissen fundoplication and combined procedures to reduce recurrence of gastroesophageal reflux disease in neurologically impaired children
Authors: Ceriati Emanuela , Marchetti P. , Caccamo R. , Adorisio O. , Rivosecchi F. , De Peppo F. 
Published: July 2020

AbstractNeurologically impaired children account for almost half of the fundoplication procedures performed for gastroesophageal reflux disease. Aim of the present study was to report results of antireflux surgery in neurologically impaired children. A retrospective study of neurologically impaired children who underwent fundoplication over a 13-year period (1999–2012) was performed. Recurrence rate, major complications and parents/caregivers perceptions of their child's quality of life following antireflux surgery were analyzed. A total of 122 children (median age: 8 years 9 months; range: 3 months to 18 years) had open “tension-free” Nissen fundoplication, gastrostomy + /− pyloroplasty. Gastroesophageal reflux disease was in all cases documented by at least two diagnostic exams. Median duration of follow-up was 9.7 (1.9–13) years. Three (2.4%) recurrences were documented and required surgery re-do. Major complications were 6%. Seventy-nine of 87 (90%) caregivers reported that weight gain was improved after fundoplication with a median score of 1 (IQR: 1–2). Significant improvement was perceived in postoperative overall quality of life. In this series of fundoplication recurrence incidence was low, serious complications were uncommon and caregivers’ satisfaction with surgery was high. Accurate patient’s selection and creating a “low-pressure” surgical system are mandatory to obtain these results.
Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
Authors: Lee Da Young , Han Kyungdo , Yu Ji Hee , Park Sanghyun , Heo Jee-In , Seo Ji A. , Kim Nam Hoon , Yoo Hye Jin , Kim Sin Gon , Kim Seon Mee , Choi Kyung Mook , Baik Sei Hyun , Park Yong Gyu , Kim Nan Hee 
Published: July 2020

AbstractThe aim of this study is to investigate whether GGT variability is able to predict the risk of end-stage renal disease (ESRD). The study subjects were Koreans who conducted health exams supported by the Korean National Health Insurance Corporation during 2009–2012 (baseline). After excluding individuals aged < 40 years, heavy alcoholics, or those with histories of chronic liver disease or ESRD, we followed 6,058,995 individuals. We calculated the average successive variability (ASV) of GGT values during the 5 years before the baseline as a parameter of variability. Using Cox proportional analyses, we evaluated the risk of ESRD according to GGT ASV quartiles, defined as the initiation of renal replacement therapy or kidney transplantation, or December 31, 2016. During 38,663,279.3 person-years of follow-up, 12,057 cases of ESRD were identified. Compared with GGT ASV quartile 1, the risk of ESRD was higher in ASV quartiles 3–4 and increased serially, even after adjustment for several metabolic parameters, baseline renal function, presence of comorbidities, low income, and baseline GGT and hemoglobin level. The fully adjusted hazard ratios (95% confidence intervals) of GGT ASV quartiles 3 and 4 were 1.06 (1.01–1.12) and 1.12 (1.06–1.18), respectively. In conclusion, GGT variability is a putative risk factor for ESRD in Koreans.
Fluorescent artificial receptor-based membrane assay (FARMA) for spatiotemporally resolved monitoring of biomembrane permeability
Authors: Biedermann Frank , Ghale Garima , Hennig Andreas , Nau Werner M. 
Published: July 2020

AbstractThe spatiotemporally resolved monitoring of membrane translocation, e.g., of drugs or toxins, has been a long-standing goal. Herein, we introduce the fluorescent artificial receptor-based membrane assay (FARMA), a facile, label-free method. With FARMA, the permeation of more than hundred organic compounds (drugs, toxins, pesticides, neurotransmitters, peptides, etc.) through vesicular phospholipid bilayer membranes has been monitored in real time (µs-h time scale) and with high sensitivity (nM-µM concentration), affording permeability coefficients across an exceptionally large range from 10–9–10–3 cm s–1. From a fundamental point of view, FARMA constitutes a powerful tool to assess structure-permeability relationships and to test biophysical models for membrane passage. From an applied perspective, FARMA can be extended to high-throughput screening by adaption of the microplate reader format, to spatial monitoring of membrane permeation by microscopy imaging, and to the compartmentalized monitoring of enzymatic activity.
Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice
Authors: Shimuta Misa , Sugihara Izumi , Ishikawa Taro 
Published: July 2020

AbstractThe cerebellum receives signals directly from peripheral sensory systems and indirectly from the neocortex. Even a single tactile stimulus can activate both of these pathways. Here we report how these different types of signals are integrated in the cerebellar cortex. We used in vivo whole-cell recordings from granule cells and unit recordings from Purkinje cells in mice in which primary somatosensory cortex (S1) could be optogenetically inhibited. Tactile stimulation of the upper lip produced two-phase granule cell responses (with latencies of ~8 ms and 29 ms), for which only the late phase was S1 dependent. In Purkinje cells, complex spikes and the late phase of simple spikes were S1 dependent. These results indicate that individual granule cells combine convergent inputs from the periphery and neocortex and send their outputs to Purkinje cells, which then integrate those signals with climbing fiber signals from the neocortex.
Lebensmittelvergiftung durch Cucurbitacine
Authors: Jung Carlo , Steuber Benjamin , Schwörer Harald 
Published: July 2020

Zusammenfassung
Anamnese und klinischer Befund Die 66-jährige Patientin ist wegen einer akuten Lebensmittelvergiftung nach Ingestion von bitteren Zucchini in die Notaufnahme mit Tachykardie, Hypotonie und Somnolenz sowie Exsikkose, Übelkeit, Erbrechen und Hämatochezie eingewiesen worden.
Untersuchungen und Diagnose Auffällig waren eine Leukozytose sowie sonografisch eine Kolitis. Die Diagnose einer akuten Lebensmittelvergiftung mit hämorrhagischer Kolitis, ausgelöst durch Cucurbitacin – haltige Zucchini, wurde gestellt.
Therapie und Verlauf Nach intravenöser Volumensubstitution stabilisierte sich die Patientin. Die Kolitis war selbstlimitierend. Eine orale Nahrungsaufnahme war nach 2 Tagen möglich.
Folgerung Akute Lebensmittelvergiftungen mit Cucurbitacin-haltigen Kürbisgewächsen sind rar, können aber bei Gewächsen im Kleingartenbereich, in Verbindung mit erhöhten Außentemperaturen, vorkommen. Cucurbitacin-Vergiftungen müssen in die Differenzialdiagnose einer Lebensmittelvergiftung einbezogen werden. Anamnestisch ist die Erwähnung des bitteren Geschmacks ausschlaggebend.
Sicherheitsmanagement der Therapie mit Antimalariamitteln: was
bedeuten die neuen Empfehlungen für die Praxis?
Authors: Hadjiski Denitsa , Fiehn Christoph 
Published: July 2020

ZusammenfassungAntimalariamittel (AM) haben nach wie vor eine große Bedeutung in der
Rheumatologie. Die aktualisierten Empfehlungen zum Sicherheitsmanagement mit AM
wurden auf der Basis einer systematischen Literaturaturrecherche und im
interdisziplinären Konsens erarbeitet. Verantwortlich war die Kommission
Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie. Um
Nebenwirkungen frühzeitig zu entdecken, bzw. Komplikationen im
Zusammenhang mit der AM-Therapie vorzubeugen, sind folgende Maßnahmen
empfohlen: Die rheumatologische Therapie mit AM sollte mit Hydroxychloroquin
(HCQ) erfolgen und die Dosis von 5 mg/kg Körpergewicht (KG)
nicht übersteigen. In den ersten 6 Monaten der Therapie ist eine
augenärztliche Untersuchung empfohlen. Risikofaktoren für die
Entwicklung einer AM-induzierten Retinopathie sind vorbestehende Makulopathie,
Niereninsuffizienz mit glomerulärer Filtrationsrate (GFR)< 60
ml/min, Tamoxifen-Begleittherapie, Tagesdosen HCQ > 5
mg/kg KG, sowie die Therapie mit Chloroquin (CQ). Bei Vorliegen von
Risikofaktoren werden die weiteren Kontrolluntersuchungen einmal pro Jahr
empfohlen, ansonsten erst ab dem fünften Jahr, dann ebenfalls
jährlich. Die ophthalmologische Untersuchung sollte mindestens eine
subjektive und eine objektive Methode beinhalten. Empfohlen wird jeweils das
automatisierte Gesichtsfeld (aGF) und die optische Kohärenztomografie
(OCT). In der aGF lassen bei einer AM-Retinopathie eine parafoveale
Empfindlichkeitsabnahme und in der OCT eine umschriebene Verdünnung der
Photorezeptorenschicht parafoveal sowie fokale Unterbrechung der
Außensegmentstrukturlinie den Verdacht auf eine AM-Retinopathie zu. Zur
Erkennung von Kardiomyopathie bzw. Myopathie wird zu Beginn und dann alle
3–6 Monate die Bestimmung von Creatinkinase (CK) und Laktatdehydrogenase
(LDH) im Serum empfohlen. Ergänzend können bei Verdacht auf
AM-induzierte Kardiomyopathie Troponin, brain natriuretic peptide (BNP),
Elektrokardiogramm (EKG), sowie eine kardiale Magnetresonanztomografie (MRT)
erwogen werden. Bei Verdacht auf AM-induzierte Myopathie ist die Muskelbiopsie
mit elektronenmikroskopischer Untersuchung der Goldstandard. Die Behandlung mit
HCQ verursacht bei Einnahme in der Schwangerschaft keine Fehlbildungen der
ungeborenen Kinder und ist sowohl in der Schwangerschaft wie auch Stillzeit nach
gegenwärtigem Wissenstand sicher. Die aktualisierten Empfehlungen zum
Sicherheitsmanagement der Therapie mit AM enthalten strengere Dosisvorgaben,
Definition für Risikofaktoren für AM-Retinopathie und geeignete
ophthalmologische Untersuchungen, sowie Stratifizierung im Monitoring.
Rheumatologische paraneoplastische Syndrome
Authors: Knitza Johannes , Schett Georg , Manger Bernhard 
Published: July 2020

ZusammenfassungRheumatologische paraneoplastische Syndrome sind selten, stellten jedoch eine
wichtige Differenzialdiagnose zu klassischen rheumatologischen Krankheitsbildern
dar. Durch das Erkennen der eindrücklichen Syndrome mit typischen Labor-
und Untersuchungsbefunden ist oftmals eine beschleunigte Diagnose der
zugrundeliegenden Malignität und kurative Therapie möglich. In
dieser Übersichtsarbeit werden die Charakteristika rheumatologischer
paraneoplastischer Syndrome vorgestellt.
Flexible Bronchoscopy for the Pediatric Intensivist: A New Tool in the Handbag?
Authors: Chandnani Harsha K. , Rodriguez Raul 
Published: July 2020

AbstractForeign body aspiration (FBA) is a common cause of unintentional-injury mortality. Modern bronchoscopy techniques have reduced mortality in children with FBA. In this article, we described a case of a 16-month-old child with refractory hypoxia where flexible bronchoscopy performed by the intensivist led to prompt etiology recognition and proper treatment. Patients presenting with respiratory distress with persistent hypoxia should be evaluated for FBA, considering initial chest X-ray can be normal in at least 30% of the cases. Intensivists trained in flexible bronchoscopy techniques possess a valuable tool to obtain diagnostic information avoiding delays in diagnosis and initiation of unnecessary therapies, such as extracorporeal membrane oxygenation.
Feasibility and Reliability Testing of Manual Electronic Health Record Reviews as a Tool for Timely Identification of Diagnostic Error in Patients at Risk
Authors: Soleimani Jalal , Pinevich Yuliya , Barwise Amelia K. , Huang Chanyan , Dong Yue , Herasevich Vitaly , Gajic Ognjen , Pickering Brian W. 
Published: July 2020

Abstract
Background Although diagnostic error (DE) is a significant problem, it remains challenging for clinicians to identify it reliably and to recognize its contribution to the clinical trajectory of their patients. The purpose of this work was to evaluate the reliability of real-time electronic health record (EHR) reviews using a search strategy for the identification of DE as a contributor to the rapid response team (RRT) activation.
Objectives Early and accurate recognition of critical illness is of paramount importance. The objective of this study was to test the feasibility and reliability of prospective, real-time EHR reviews as a means of identification of DE.
Methods We conducted this prospective observational study in June 2019 and included consecutive adult patients experiencing their first RRT activation. An EHR search strategy and a standard operating procedure were refined based on the literature and expert clinician inputs. Two physician-investigators independently reviewed eligible patient EHRs for the evidence of DE within 24 hours after RRT activation. In cases of disagreement, a secondary review of the EHR using a taxonomy approach was applied. The reviewers categorized patient experience of DE as Yes/No/Uncertain.
Results We reviewed 112 patient records. DE was identified in 15% of cases by both reviewers. Kappa agreement with the initial review was 0.23 and with the secondary review 0.65. No evidence of DE was detected in 60% of patients. In 25% of cases, the reviewers could not determine whether DE was present or absent.
Conclusion EHR review is of limited value in the real-time identification of DE in hospitalized patients. Alternative approaches are needed for research and quality improvement efforts in this field.
A Clinical Informatics Program Directors' Proposal to the American Board of Preventive Medicine
Authors: Pageler Natalie M. , Elkin Peter L. , Kannry Joseph , Leu Michael G. , Levy Bruce , Lehmann Christoph U. 
Published: July 2020

AbstractIn 2013, the American Board of Preventive Medicine (ABPM) and the American Board of Pathology (ABPath) offered the first board certification examination in Clinical Informatics to eligible physicians in the United States. In 2022, the Practice Pathway will expire and in 2023 only candidates eligible through the Fellowship Pathway will be eligible for the board certification. To date, Clinical Informatics as a specialty has not had a regular match process and used a controlled offer-acceptance process that does not meet candidates' or programs' needs. Fellows may not be offered a position with their top choice program initially, and they may accept offers from other programs to avoid risk by ensuring that they have a fellowship position. Programs have to consider losing an applicant in the first round in the ranking of applicants. The process is open to manipulation including early agreements between program directors and candidates. In this open letter to the ABPM, program directors make the case for a third-party match and are calling on the ABPM to leverage its status as the Clinical Informatics certifying body and its existing infrastructure to implement a Clinical Informatics match.
Phrase-level pairwise topic modeling to uncover helpful peer responses to online suicidal crises
Authors: Jiang Meng , Ammerman Brooke A. , Zeng Qingkai , Jacobucci Ross , Brodersen Alex 
Published: July 2020

AbstractSuicide is a serious public health problem; however, suicides are preventable with timely, evidence-based interventions. Social media platforms have been serving users who are experiencing real-time suicidal crises with hopes of receiving peer support. To better understand the helpfulness of peer support occurring online, this study characterizes the content of both a user’s post and corresponding peer comments occurring on a social media platform and present an empirical example for comparison. It introduces an approach that uses pairwise topic models to transform large corpora of discussion into associated topics of user and peer posts. The key advantages of this approach include: (i) modeling both the generative process of each type of the corpora (i.e., user posts and peer comments) and the associations between them, and (ii) using phrases, which are more informative and less ambiguous than words, in addition to words, to represent social media posts and topics. The study evaluated the method using data from Reddit r/SuicideWatch. It examined how the topics of user and peer posts were associated and how this information influenced the peer perceived helpfulness of the peer support. Then, this study applied structural topic modeling to data collected from individuals with a history of suicidal crisis as a means to validate findings. The observations suggest that effective modeling of the association between the two lines of topics can uncover helpful peer responses to online suicidal crises, notably providing the suggestion of professional help. The proposed technology can be applied to “paired” corpora in many applications, such as technical support forums, question-answering sites, and online medical services.
Complete microviscosity maps of living plant cells and tissues with a toolbox of targeting mechanoprobes
Authors: Michels Lucile , Gorelova Vera , Harnvanichvech Yosapol , Borst Jan Willem , Albada Bauke , Weijers Dolf , Sprakel Joris 
Published: July 2020

Significance
Spatial variations in microviscosity are triggered throughout plant cells, and these provide insight into local mechanobiological processes. However, it has so far been challenging to visualize such variations in living plant cells. Here we report an imaging microviscosity toolbox of chemically modified molecular rotors that yield complete microviscosity maps of several key plant cell structures. This toolbox opens up new ways to understand the role of mechanical stress in the regulation of biological processes.
BTZ gems inside regular Born–Infeld black holes
Authors: Böhmer Christian G , Fiorini Franco 
Published: July 2020

Abstract
The regular black hole solution arising as a spherically symmetric vacuum solution of Born–Infeld gravity possesses an asymptotic interior structure which is very well described by a four-dimensional generalization of the non-rotating BTZ metric. According to this picture no singularity exists, and instead, infalling observers experience a constant curvature manifold as they travel towards future null infinity. This is characterized by the BTZ event horizon. The exterior structure of the black hole is also studied, and it is shown that it corresponds to the Schwarzschild solution provided the black hole mass is not too small. In this way, the regular black hole state can be seen as a spacetime which connects two constant curvature asymptotic spaces, namely, the flat Minkowski spacetime in the outside region, and the locally AdS constant negative curvature one characterizing the BTZ-like asymptotic interior.
Accurate and fast out-of-plane displacement measurement of flat objects using single-camera based on the sampling moiré method
Authors: Ri Shien 
Published: July 2020

Abstract
Out-of-plane displacement measurement is an important task not only to analyze the microelectronic device’s behavior at the micro-scale but also to evaluate the structural health monitoring (SHM) of infrastructures at the meter-scale. In this study, an accurate and fast out-of-plane displacement measurement method with a single camera is presented, including the theoretical equations, and calibration of phase-gradient to out-of-plane displacement. Since the proposed method requires only a single grating image before and after deformation and analyzes by the sampling moiré method, it yields high accuracy and speed. An experiment of out-of-plane displacement with three different focal length lenses has been conducted to verify the validity of this method. Experimental results indicated that both small and large out-of-plane displacement measurements could be performed accurately. This optical measurement technique will be of high value for SHM of various infrastructures under digital camera or video/cinema camera recording.
Anomalous magnetoresistance in centrosymmetric skyrmion-lattice magnet Gd2PdSi3
Authors: Zhang Han , Huang Qing , Hao Lin , Yang Junyi , Noordhoek Kyle , Pandey Shashi , Zhou Haidong , Liu Jian 
Published: July 2020

Abstract
We performed a systematic study of the temperature- and field-dependence of magnetization and resistivity of Gd2PdSi3, which is a centrosymmetric skyrmion crystal. We show that a phase diagram can be constructed based on the anomalous magnetoresistance with one-to-one correspondence among all the feature, while the DC magnetization behavior is consistent with the reported phase diagram based on AC susceptibility. In addition, the crossover boundary from a paramagnetic state into the field-induced ferromagnetic state is also identified. Our results suggest that the ferromagnetic spin fluctuations above the Néel temperature play a key role in the high sensitivity of the resistivity anomalies to magnetic field, pointing to the rich interplay of different magnetic correlations at zero and finite wave vectors underlying the skyrmion lattice in this frustrated itinerant magnet.
Toxicity of chlorpyrifos insecticide on Asian red-tailed catfish (Hemibagrus nemurus) and its degradation potency using activated carbon
Authors: Taufik I , Setijaningsih L , Widyastuti Y R , Setiadi E 
Published: July 2020

Abstract
The chlorpyrifos is an insecticide with high toxicity and persistence in nature. The activated carbon has the potency to degrade some insecticides through the adsorption process. The research aimed to determine the lethal toxicity (LC50-96 hours) of the chlorpyrifos insecticide or red tail fingerling. The fish with 2.5±0.2 cm in total length and 0.18 ± 0.002 g in body weight were used. The concentrations of the chlorpyrifos as a treatment were 0.0, 1.0, 1.4, 1.9, 2.7, 3.8, 5.6, and 7.5 mg/l. Three kinds of experiments were set up, namely, without activated carbon (as a control), coconut shell activated carbon, and wood activated carbon. Each treatment consisted of three replicates. The probit analysis performed to obtain the LC50-96 hours’ value. The result showed that the LC50-96 hours of Asian catfish was 4.44 mg/l (without activated carbon), 4.84 mg/l (coconut shell activated carbon), and 8.52 mg/l (wood activated carbon). The effectiveness ol activated carbon to reduce the toxic of the chlorpyrifos found on the wood activated carbon (91.9%) then followed by the coconut shell activated carbon was 9.0%. Thus the implementation of the wood activated carbon is fruitful in terms of reducing the chlorpyrifos toxic.