bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of SPECT Concentric Ring Artifacts by Radiomics and Radial Features
Authors: Mezzenga Emilio , Sarnelli Anna , Bellomo Giovanni , DiFilippo Frank P , Palestro Christopher J , Nichols Kenneth J 
Published: September 2020

Abstract
Background: Conspicuous concentric ring artifacts in phantom reconstructions triggers retuning SPECT systems. These evaluations are visual, not quantitative. Our study was undertaken to determine the degree to which observers agree about SPECT concentric ring artifacts, and to test whether quantitative texture analysis metrics correspond to significant artifacts.Methods: Test data were acquired as part of quarterly quality assurance using standardized SPECT phantoms containing solid spheres, solid rods and volumes of uniform activity concentration loaded with 99mTc. Forty SPECT studies were identified as having concentric ring artifacts or were acquired to assess whether artifacts were resolved following camera retuning after obtaining an unacceptably non-uniform result. Transaxial reconstructions were reviewed independently by two medical physicists who graded severity of artifacts on a 5-point scale. Counts were tabulated in volumes of interest created in uniform phantom sections, from which were computed 72 radiomics image texture analysis metrics. Radial contrast (RContrast) derived from the radial profile of summed slices transformed into polar coordinates and radial noise-to-signal (RNSR) also calculated. Results: Artifacts were considered sufficiently severe to require camera retuning in 10 rods sections, 17 sphere sections, and 16 uniform sections. In uniform sections, there was “good agreement” for inter-observer and intra-rater assessments (κ = 0.66, Fisher exact p < 0.0001 and κ = 0.61, Fisher exact p = 0.001, respectively). While 3 radiomics image analysis features agreed significantly (p = 0.001) with visual detection of significant artifacts in uniform sections, the parameters most strongly associated with severe artifacts were RContrast > 4.75% and RNSR > 2.7%, for which ROC AUC accuracy = 88%±5%, sensitivity = 83%, specificity = 83%, p < 0.0001. Accuracy was 76%-78% for the 3 radiomics features, with significantly lower specificity (48%-61%, p < 0.05) than RContrast and RNSR. Increasing magnitude of RContrast and RNSR correlated significantly with increasingly severe artifact scores (ρ = 0.71-0.72, p < 0.0001). Conclusion: There was good agreement among physicists as to the presence of circular ring artifacts in uniform sections of SPECT quality assurance scans, with artifacts accurately detected by radial contrast and noise-to-signal ratio measurements.
Examination of Referral Source and Retention Among Women in Residential Substance Use Disorder Treatment: A Prospective Follow-Up Study
Authors: Rivera Dean , Dueker Donna , Amaro Hortensia 
Published: September 2020

Abstract
Background: Court-mandated substance use disorder (SUD) treatment, as compared to nonmandated treatment, has been associated with increased retention and completion. However, whether child protective services (CPS)-mandated women’s residential SUD treatment leads to improved treatment retention in comparison to criminal justice (CJ)-mandated and nonmandated treatment remains unclear. Purpose: This study compared the number of days retained in residential SUD treatment among three referral sources (CPS, CJ, and nonmandated), while also examining whether having a co-occurring mental health disorder or certain mental health characteristics (increased stress, depression, anxiety, and PTSD symptomology) contributed to decreased retention. This study tested the hypothesis that women mandated by the CPS and CJ systems would have improved residential SUD treatment retention compared with nonmandated women. Methods: Multivariate regression analyses were conducted on data for a diverse sample of 245 women (Hispanic: N = 141, Black: N = 50, White: N = 50) mandated or nonmandated (CJ: N = 114, CPS: N = 82, nonmandated: N = 49) into residential SUD treatment to determine each group’s treatment retention outcomes. Results: Women mandated to SUD residential treatment regardless of source (CPS or CJ) remained in treatment significantly longer (CPS: M = 116.59 days, SD = 65.59, p = .023; CJ: M = 133.86 days, SD = 79.43, p = .028), compared to women not mandated (M = 96.11 days, SD = 72.09), representing a 34.4% and 31.6% increase, respectively. Findings further revealed a corresponding 2.3% decrease in retention (p = .024) for each one-unit increase in a patient’s stress score, whereas those with a co-occurring mental health diagnosis had a 43.6% decrease in SUD treatment retention (p < .001). Conclusions: This study highlights the importance of future research that examines the impact of referral source, co-occurring mental disorders, and stress on women’s residential SUD treatment retention.Further research is needed examining the variability in external motivation among referral sources compounded by dynamic intersections of risk associated with having a co-occurring disorder and stress on treatment retention.ClinicalTrials.gov Identifier: NCT02977988 (first posted November 30, 2016; last update posted October 7, 2019); U.S. NIH Grant/Contract: 5R01DA038648
The Influence of Adsorption Small Molecules Atrazine on Nonvolatile Resistive Switching Behavior in Co-Al Layered Double Hydroxide Films
Authors: Sun Yanmei , Li Li , Shi Keying 
Published: September 2020

Abstract
Co-Al layered double hydroxides (LDHs) thin films were prepared by drop-casting process on ITO coated glass substrates. And then the small molecule atrazine was adsorbed on the Co-Al LDHs film by impregnation method. Current-voltage characteristics revealed nonvolatile resistive switching in Co-Al LDHs adsorbed atrazine films. The Influence of adsorption small molecules atrazine on nonvolatile resistive switching behavior in Co-Al LDHs Film has been investigated. By varying the atrazine adsorbed content in Co-Al LDHs thin films, the nonvolatile resistive switching behavior of device could be adjusted in a controlled way. Entirely different nonvolatile resistive switching characteristic, such as write-once read-many-times memory effect and rewritable memory effect are discriminable by the current-voltage curves.
A real world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis
Authors: Wright William Alexander , Crowley Louise , Parekh Dhruv , Crawshaw Anjali , Dosanjh Davinder , Nightingale Peter , Thickett David 
Published: September 2020

Abstract
Background Pirfenidone and nintedanib are the only disease-modifying treatments available for idiopathic pulmonary fibrosis (IPF). Our aim was to test their effectiveness and safety in clinical practice.Methods This is a single centre retrospective observational study undertaken at a specialised interstitial lung disease centre in England. Data including progression-free survival (PFS), mortality and drug tolerability were compared between IPF patients on antifibrotic therapies and an untreated control group who had a forced vital capacity percentage (FVC %) predicted within the licensed antifibrotic treatment range.Results 104 patients received antifibrotic therapies and 64 control patients were identified. PFS at 6 months was significantly greater in the antifibrotic group (75.0%) compared to the control group (56.3%) (p=0.012). PFS was not significant at 12 or 18 months. The 12-month post-treatment mean decline in FVC% predicted (-4.6±6.2%) was significantly less than the 12-month pre-treatment decline (-10.4 ±11.8%) (p=0.039). The 12-month mortality rate was not significantly different between the antifibrotic group (25.3%) and the control group (35.5%) (p=0.132). Baseline BMI≤25, baseline DLco% predicted ≤35 and antifibrotic discontinuation within 3 months were independent predictors of 12-month mortality. Antifibrotic discontinuation was significantly higher by 3 and 6 months for patients on pirfenidone than those on nintedanib (p=0.006 and p=0.044, respectively). Discontinuation at 12 months was not significantly different (p=0.381).Conclusion This real-world study revealed that antifibrotics are having promising effects on PFS, lung function and mortality. These findings may favour commencement of nintedanib as first line antifibrotic therapy, given the lower rates of early treatment discontinuation.
Mir-320b Inhibits Pancreatic Cancer Cell Proliferation by Targeting FOXM1
Authors: Jingyang Zhou , Jinhui Che , Lu Xu , Weizhong Yang , Yunjiu Li , Haihong Wang , Wuyuan Zhou 
Published: September 2020

Backround:Pancreatic ductal adenocarcinoma (PDAC) is the most common and deadly cancer. Surgical resection is the only possible cure for pancreatic cancer but often has a poor prognosis, and the role of adjuvant therapy is urgently explored.Methods:MicroRNAs (miRNAs) play very important role in tumorigenesis by regulating the target genes. In this study, we identified miR-320b lower-expressed in human pancreatic cancer tissues but relatively higher-expressed in the adjacent nontumor tissues.Results:Consistently，the expression of miR-320b in different pancreatic cancer cell lines was significantly lower than the normal pancreatic cells. In order to identify the effects of miR-320b on cell growth, we overexpressed miR-320b in PANC-1 and FG pancreatic cancer cell lines, CCK8 and BrdU incorporation assay results showed that miR-320b inhibited cell proliferation.Discussion:We next predicted miR-20b targeted FOXM1（Forkhead box protein M1）and identified the negative relationship between miR-320b and FOXM1.We also demonstrated that elevated miR-320b expression inhibited tumor growth in vivo.Conclusion:All of these results showed that miR-320b suppressed pancreatic cancer cells proliferation by targeting FOXM1, which might provide a new diagnostic marker for pancreatic cancer.
Is there a Relationship Between Gestational Diabetes and Postpartum Depression?
Authors: Khazaei Salman , Ayubi Erfan , Bashirian Saeid , Hamzehei Ronak , Jenabi Ensiyeh 
Published: September 2020

Background:
The relationship between gestational diabetes and postpartum depression
(PPD) is poorly understood and seldom studied.

Objective:
In an effort to explore this issue, the present study investigated the relationship between
gestational diabetes and PPD.

Methods:
The present cross-sectional study was performed on 342 women who were referred to
four urban health centers of Hamadan city, west of Iran. We used convenience sampling as a
method to recruit women in each health center. We used a researcher-made checklist for gathering
data on socio-demographic characteristics and potential risk factors of PPD. The Persian validated
version of the Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Univariate
and multivariable binary logistic regression was applied to estimate the odds ratio (OR) (95% confidence
interval [CI]).

Results:
Gestational diabetes was identified as the most important risk factor for PPD with OR
(95% CI) of 2.19 (1.11, 4.31); P-value=0.02 after adjusting for other variables. Moreover, the adjusted
odds ratio showed that PPD among less-educated women (primary school) was 3.5 times higher
compared to women with a university education (OR=3.54, 95% CI: 1.27, 9.84; P-value=0.01).

Conclusion:
Our findings suggested that PPD is more likely among women with gestational diabetes
and those who are less educated. Interventional and educational activities can be employed to
reduce the risk of PPD in this population.
Prevalence of OXA-type Class D β-lactamases Among Clinical Isolates of Klebsiella Pneumoniae in Multiple Centers of Tehran, Iran
Authors: Mehrbakhsh Pariya , Basharkhah Yalda , Bahkshi Ashraf , Kamarposhti Lida Tahmasebi Nezhad , Bolori Shahin 
Published: September 2020

Background:
Drug- and multidrug-resistant Klebsiella pneumoniae isolates have been
found worldwide. Treatment failures against carbapenems and extended-spectrum cephalosporins,
the currently recommended drugs, contribute to consider K. pneumoniae infections as untreatable
infections. The emergence and spread of oxacillinases (OXAs) with carbapenem-hydrolyzing properties
are a major concern and seriously become a public health problem worldwide. The present
study was aimed to explore the blaOXA genes among clinical isolates of K. pneumoniae in some clinical
settings in Tehran, Iran.

Methods:
A total of 90 K. pneumoniae isolates were collected from different clinical samples at
hospitals in Tehran during the year 2016 and 2018. Antimicrobial susceptibility testing was performed
on bacterial isolates using the Kirby-Bauer disc diffusion method on Mueller Hinton agar
plates. PCR experiments were carried out to detect the presence of the blaOXA genes, including blaOXA-
1, blaOXA-2, blaOXA-4, blaOXA10, and blaOXA-48-like, using specific primers.

Results:
The antibiotics susceptibility results showed that 41% of the K. pneumoniae isolates were
resistant to imipenem and meropenem. Resistance rates for cephalosporin agents, including cefpodoxime,
ceftazidime, cefuroxime, cefotaxime, and cefepime, were measured as 72.3%, 67.8%,
67.7%, 65.5%, and 60%, respectively. In the present study, 51.1% of isolates were classified as
multidrug-resistant K. pneumoniae strains. The molecular assays showed that 56.6% of isolates harbored
blaOXA-2. In addition, blaOXA-4, blaOXA-1, blaOXA-10, and blaOXA-48-like genes were also found in
16.7%, 5.6%, 1.1%, and 1.1% of isolates, respectively.

Conclusions:
The spread of blaOXAs, especially blaOXA-48-like, among K. pneumoniae isolates indicated
the inadequate dissemination control of multidrug-resistant bacteria in the Iranian hospital environment.
There is a reason to assume that OXA producing K. pneumoniae will limit clinical therapeutic
options in the future and pose threats to national public health among the Iranian population.
The Occurrence and Risk Assessment of Aflatoxin M1 in Yoghurt Samples from Hamadan, Iran
Authors: Heshmati Ali , Mozaffari Nejad Amir Sasan Mozaffari , Ghyasvand Tayebeh 
Published: September 2020

Background:
Aflatoxin M1 (AFM1) is a hepatocarcinogenic and hydroxylated metabolite of aflatoxin B1, detected in milk and milk products.

Objectives:
The aim of our research was to determine the incidence and risk assessment of AFM1 through the consumption of yoghurt in Hamadan province of Iran.

Methods:
Fifty yoghurt samples were gathered from various areas of Hamadan province, Iran and tested for AFM1 by ELISA technique. The estimated daily intake (EDI) and the liver cancer incidence of aflatoxin M1 were determined.

Results:
AFM1 was detected in 43 (86%) samples, (mean: 28.56 ng/kg; range: <5-98.65 ng/kg). The level of AFM1 in 9 (18%) samples was above the maximum tolerance limit (50 ng/kg). The AFM1 intake through yoghurt consumption in various population groups ranged from 0.016 to 0.032 ng/kg bw/day in mean consumers and 0.019 to 0.046 ng/kg bw/day in high consumers.

Conclusion:
The AFM1 intake through yoghurt contributed a slight part from the overall incidence of liver cancer in the Iranian population. From the findings of the current study, it can be derived that although the high percentage of yoghurt samples in Iran proved to be contaminated with AFM1 contents, did not show a public health concern considering the European Commission (EC) and the Institute of Standards and Industrial Research of Iran (ISIRI) maximum limits.
Transient Free Convective Flow of CNT Water Nanofluid with Heat Transfer from a Moving Cylinder
Authors: Sridevi C. , Sailakumari A. 
Published: September 2020

Background:
In this paper, transient two-dimensional laminar boundary layer viscous incompressible
free convective flow of water based nanofluid with carbon nanotubes (CNTs) past a
moving vertical cylinder with variable surface temperature is studied numerically in the presence of
thermal radiation and heat generation.

Methods:
The prevailing partial differential equations which model the flow with initial and boundary
conditions are solved by implicit finite difference method of Crank Nicolson type, which is unconditionally
stable and convergent.

Results:
Influence of Grashof number (Gr), nanoparticle volume fraction (φ), heat generation parameter
(Q), temperature exponent (m), radiation parameter (N) and time (t) on velocity and temperature
profiles are sketched graphically and elaborated comprehensively.

Conclusion:
Analysis of Nusselt number and Skin friction coefficient is also discussed numerically
for both single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs).
Microwave-assisted Green Synthesis of β-Diketone Hydrazone Derivatives and Evaluation of their Antioxidant and Antibacterial Activities
Authors: Syed Ameen Syed Tajudeen , Vilvanathan Anbalagan , Khader Syed Zameer Ahmed , Mahalingam Gayathri 
Published: September 2020

Background:
A series of β-diketone hydrazones have been synthesized via condensation
of isoniazid with series of β-diketone. The structures of the Schiff bases are established by elemental
and spectroscopic techniques. The prepared compounds were screened for antibacterial and
antioxidant potential by DPPH free-radical scavenging activity and Ferric reducing antioxidant
power (FRAP) assays.

Methods:
β-diketone hydrazine derivatives were synthesized by simple condensation between various
β-diketones and isoniazid. The titled compounds were synthesized following both conventional
and microwave irradiation methods. The in vitro antibacterial activity of synthesized derivatives
was evaluated against gram-positive (B. subtilis, S. aureus and S. pyogenes) and gram-negative (E.
coli, and K. pneumonia) bacterial strains and expressed in terms of zone of inhibition and also
screened for antioxidant activity.

Results:
The yield of products was appreciably increased in shorter reaction times with the aid of
microwave-assisted synthesis. Therefore, it follows the green chemistry approach by making the
above reactions eco-friendly. The synthesized compounds were characterized using FT-IR, 1H
NMR, 13C NMR, and elemental analysis techniques. The spectroscopic techniques showed the formation
of β-diketone hydrazone compounds. Theoretical data show good agreement with the experimental
results. Some of the compounds displayed significant antibacterial and antioxidant potentials
when compared to the standard drug.

Conclusion:
In the present research work, we report the synthesis of some novel β-diketone hydrazone
derivatives. A high yield of compounds was noted under microwave-assisted reaction in shorter
reaction times. The results revealed that the synthesized Schiff bases showed good radical scavenging
activity.
A INCIDENCE, PREVALENCE, AND CLINICAL MANAGEMENT OF POISONING CASES IN TELANGANA STATE REGION – A PROSPECTIVE STUDY
Authors: HARISHWARREDDY POTHULA , D NAGALATHA , G VEENA 
Published: September 2020

Objectives: This study aimed to find the incidence, prevalence, and clinical management of poisoning cases in Telangana state region.
Methods: It was a prospective and observational study done for 9 months and the data were obtained from the case sheets of 600 patients admitted in tertiary care hospital with poisoning. Data were analyzed according to age, gender, type and route of poisoning, treatment of poisoning, and mortality and morbidity rate.
Results: Out of 600 cases admitted, female patients were 312 (52%) and males were 288 (48%) and the age group ranged from 6 months to 70 years of age. The most common route of exposure was ingestion (oral) (91.5%) followed by topical (dermal) (8%), and the agents which were used included organophosphate (33%) in most of the cases followed by chemical poisoning (24%). The average duration of therapy till the discharge of the patients was 1–5 day. About 80% of the cases were from the low socioeconomic background. More or less, the treatment is restricted to symptomatic and supportive care if the poisonous agent is unknown. A specific antidote is given, where there is enough information regarding the poison.
Conclusion: The present study revealed increasing incidence of poisoning cases from rural areas and below the poverty line due to lack of knowledge, easy availability, stress, depression, and familial disharmony. By providing educational, awareness programs, and establishing a poison information center, there is a possibility for a decline in the incidence of poisoning.
OXIDATIVE METABOLISM AND PHYSICAL PROPERTIES OF THE BLOOD IN ATHLETES
Authors: MARTUSEVICH ANDREW K , A KARUZIN KONSTANTIN 
Published: September 2020

Objectives: Monitoring of metabolic status in athletes includes a wide range of different parameters, but not all of them have been fully studied. Thus, the presence of oxidative stress is noted in athletes, but its features are revealed only in fragments. The crystallogenic properties of blood in athletes have not been previously studied.
Methods: The study enrolled a total of 262 athletes (19–29 years old) that are highly qualified in cyclic sports. Furthermore, screening data of apparently healthy non-exercising volunteers of the same age (n=35) were used for control. Blood serum of the athletes and non-exercising volunteers was analyzed for 8-isoprostane level, oxidized low-density lipoproteins, activity of superoxide dismutase, and glutathione peroxidase and reductase. We also studied the level α- and β-carotenes, α- and γ-tocopherols, lycopene, lutein, and zeaxanthin. Crystallogenic properties of blood serum were tested with own method.
Results: The complex study demonstrated the presence of shifts in oxidative metabolism and blood serum physical and chemical properties induced by professional sports and manifested both in the status of blood pro- and antioxidative systems and in shifts of biofluids crystallogenic activity. At the same time, the obtained data confirmed the development of oxidative stress in qualified athletes.
Conclusion: Our data shown that there are some shifts of oxidative metabolism and crystallogenic properties of blood plasma in professional athletes.
PROSPECTIVE STUDY OF THE SIDE EFFECTS BETWEEN ATYPICAL–ATYPICAL ANTIPSYCHOTIC COMBINATIONS WITH TYPICAL-ATYPICAL ANTIPSYCHOTIC COMBINATIONS ON THE PSYCHOTIC DISORDERS INPATIENTS
Authors: FUTIHAT CHILYATI EKY , DARMAWAN ENDANG , IKAFITRIANI ASTRIT 
Published: September 2020

Objective: Antipsychotic therapy is the main therapy in psychotic disorders. Antipsychotics use often causes various side effects, such as the orthostatic hypotension, weight gain, and waist circumference. The study objective is to prove these side effects on combination therapy of atypical-atypical and typical-atypical antipsychotics on the psychotic disorders in patients.
Methods: This study method is a prospective cohort applied to psychotic disorders inpatients. This study is composed of 2 different groups(n=16). Data analysis using Risk Relative Ratio for orthostatic hypotension study variables and statistical difference test with 95% confidence level for study variables of weight gain and waist circumference.
Results: The p value showed that there was no significant side effects of orthostatic hypotension (p>0.05). Relative Risk Ratio (RR) value explained that the atypical-atypical antipsychotic combination group had opportunity to cause orthostatic hypotension side effects by 2,000 times greater than the typical-atypical antipsychotic combination group at 0th week observation and 1,667 times greater than the typical-atypical antipsychotic combination group at 1st and 2nd week observations. Atypical-atypical antipsychotic combinations use and typical-atypical antipsychotic combinations use cause insignificant weight gain (p>0.05). Typical-atypical antipsychotic combination use in the 2nd week increases waist circumference greater than atypical-atypical antipsychotic combination use in the 2nd week (p<0.05).
Conclusion: Typical-atypical antipsychotic combinations use and atypical-atypical antipsychotic combination use did not cause significant on orthostatic hypotension and weight gain. Significant test results appear on the waist circumference increasing in the second week of typical-atypical antipsychotic combinations use when compared to atypical-atypical antipsychotic combinations use.