bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype
Authors: Corbin Laura J. , Hughes David A. , Chetwynd Andrew J. , Taylor Amy E. , Southam Andrew D. , Jankevics Andris , Weber Ralf J. M. , Groom Alix , Dunn Warwick B. , Timpson Nicholas J. 
Published: June 2020

Abstract
Introduction
High plasma triacylglyceride levels are known to be associated with increased risk of atherosclerotic cardiovascular disease. Apolipoprotein C-III (apoC-III) is a key regulator of plasma triacylglyceride levels and is associated with hypertriglyceridemia via a number of pathways. There is consistent evidence for an association of cardiovascular events with blood apoC-III level, with support from human genetic studies of APOC3 variants. As such, apoC-III has been recognised as a potential therapeutic target for patients with severe hypertriglyceridaemia with one of the most promising apoC-III-targeting drugs, volanesorsen, having recently progressed through Phase III trials.

Objectives
To exploit a rare loss of function variant in APOC3 (rs138326449) to characterise the potential long-term treatment effects of apoC-III targeting interventions on the metabolome.

Methods
In a recall-by-genotype study, 115 plasma samples were analysed by UHPLC-MS to acquire non-targeted metabolomics data. The study included samples from 57 adolescents and 33 adults. Overall, 12 985 metabolic features were tested for an association with APOC3 genotype.

Results
144 uniquely annotated metabolites were found to be associated with rs138326449(APOC3). The highest proportion of associated metabolites belonged to the acyl-acyl glycerophospholipid and triacylglyceride metabolite classes. In addition to the anticipated (on-target) reduction of metabolites in the triacylglyceride and related classes, carriers of the rare variant exhibited previously unreported increases in levels of a number of metabolites from the acyl-alkyl glycerophospholipid and ceramide classes.

Conclusion
Overall, our results suggest that therapies targeting apoC-III may potentially achieve a broad shift in lipid profile that favours better metabolic health.
Exploring the determinants of real estate liquidity from an alternative perspective: censored quantile regression in real estate research
Authors: Cajias Marcelo , Freudenreich Philipp , Freudenreich Anna 
Published: June 2020

AbstractIn this paper, the liquidity (inverse of time on market) of rental dwellings and its determinants for different liquidity quantiles are examined for the seven largest German cities. The determinants are estimated using censored quantile regressions in order to investigate the impact on very liquid to very illiquid dwellings. As market heterogeneity is not only observed between cities but also within a city, each of the seven cities is considered individually. Micro data for almost 500,000 observations from 2013 to 2017 is used to examine the time on market. Substantial differences in the magnitude and direction of the regression coefficients for the different liquidity quantiles are found. Furthermore, both the magnitude and direction of the impact of an explanatory variable on the liquidity, differ between the cities. To the best of the authors’ knowledge this is the first paper, to apply censored quantile regressions to liquidity analysis of the real estate rental market. The model reveals that the proportionality assumption underlying the Cox proportional hazards model cannot be confirmed for all variables across all cities, but for most of them.
Data acquisition and control at the edge: a hardware/software-reconfigurable approach
Authors: Streit F. , Wituschek S. , Pschyklenk M. , Becher A. , Lechner M. , Wildermann S. , Pitz I. , Merklein M. , Teich J. 
Published: June 2020

AbstractToday’s manufacturing facilities and processes offer the potential to collect data on an unprecedented scale. However, conventional Programmable Logic Controllers are often proprietary systems with closed-source hardware and software and not designed to also take over the seamless acquisition and processing of enormous amounts of data. Furthermore, their major focus on simple control tasks and a rigid number of static built-in I/O connectors make them not well suited for the big data challenge and an industrial environment that is changing at a high pace. This paper, advocates emerging hardware- and I/O reconfigurable Programmable System-on-Chip (PSoC) solutions based on Field-Programmable Gate Arrays to provide flexible and adaptable capabilities for both data acquisition and control right at the edge. Still, the design and implementation of applications on such heterogeneous PSoC platforms demands a comprehensive expertise in hardware/software co-design. To bridge this gap, a model-based design automation approach is presented to generate automatically optimized HW/SW configurations for a given PSoC. As a case study, a metal forming process is considered and the design automation of an industrial closed-loop control algorithm with the design objectives performance and resource costs is investigated to show the benefits of the approach.
The Role of Wearables in Heart Failure
Authors: Singhal Arvind , Cowie Martin R. 
Published: June 2020

AbstractPurpose of ReviewThis review discusses how wearable devices—sensors externally applied to the body to measure a physiological signal—can be used in heart failure (HF) care.Recent FindingsMost wearables are marketed to consumers and can measure movement, heart rate, and blood pressure; detect and monitor arrhythmia; and support exercise training and rehabilitation. Wearable devices targeted at healthcare professionals include ECG patch recorders and vests, patches, and textiles with in-built sensors for improved prognostication and the early detection of acute decompensation. Integrating data from wearables into clinical decision-making has been slow due to clinical inertia and concerns regarding data security and validity, lack of evidence of meaningful impact, interoperability, regulatory and reimbursement issues, and legal liability.SummaryAlthough few studies have assessed how best to integrate wearable technologies into clinical practice, their use is rapidly expanding and may support improved decision-making by patients and healthcare professionals along the whole patient pathway.
Intensive WOM-behavior in the healthcare sector – the case of an Austrian hospital’s Facebook site
Authors: Martin Sebastian , Grüb Birgit 
Published: June 2020

AbstractPatients frequently use Facebook for health-related reasons, like seeking of information or the recommendation of practitioners or hospitals. In this way, Facebook provides a powerful communication platform for electronic word-of-mouth (eWOM). Hospitals increasingly use Facebook to positively influence the perception of their brand reputation and performance. The present explorative study provides detailed information regarding eWOM behavior of persons on the Facebook page of an Upper Austrian hospital. Data of the hospital’s Facebook page was gathered and analyzed with NodeXL. By using a text analysis, we categorized the hospitals’ posts. Reactions towards the different types of postings were analyzed by counting emojis, the number of shares and comments. Within the study, there was an in-depth evaluation of communication data (313 posts of the hospital, more than 14,000 eWom actions by 3327 women, men and organizations). The study shows how heterogeneous users are in their eWOM behavior and that a variety of topics on the Facebook page stimulates electronic recommendations. One major finding of the study is that a significant part of the eWOM is done by only a few users. According to this, a so-called Intensive WOM Behavior (IWB) can be identified. Users of the IWB-group behave heterogeneously. Most react either with an emoji, a comment or a share. Only a few IWB-users respond with a combination of these eWOM-reactions. By providing first insights into the existence of IWB-users as well as their eWOM-behavior, this study offers new insights to eWOM in Facebook.
Cardiac telerehabilitation as an alternative to centre-based cardiac rehabilitation
Authors: Brouwers R. W. M. , van Exel H. J. , van Hal J. M. C. , Jorstad H. T. , de Kluiver E. P. , Kraaijenhagen R. A. , Kuijpers P. M. J. C. , van der Linde M. R. , Spee R. F. , Sunamura M. , Uszko-Lencer N. H. M. K. , Vromen T. , Wittekoek M. E. , Kemps H. M. C. ,   the Committee for Cardiovascular Prevention and Cardiac Rehabilitation of the Netherlands Society of Cardiology
Published: June 2020

AbstractMultidisciplinary cardiac rehabilitation (CR) reduces morbidity and mortality and increases quality of life in cardiac patients. However, CR utilisation rates are low, and targets for secondary prevention of cardiovascular disease are not met in the majority of patients, indicating that secondary prevention programmes such as CR leave room for improvement. Cardiac telerehabilitation (CTR) may resolve several barriers that impede CR utilisation and sustainability of its effects. In CTR, one or more modules of CR are delivered outside the environment of the hospital or CR centre, using monitoring devices and remote communication with patients. Multidisciplinary CTR is a safe and at least equally (cost-)effective alternative to centre-based CR, and is therefore recommended in a recent addendum to the Dutch multidisciplinary CR guidelines. In this article, we describe the background and core components of this addendum on CTR, and discuss its implications for clinical practice and future perspectives.
Bark beetle mycobiome: collaboratively defined research priorities on a widespread insect-fungus symbiosis
Authors: Hulcr Jiri , Barnes Irene , De Beer Z. Wilhelm , Duong Tuan A. , Gazis Romina , Johnson Andrew J. , Jusino Michelle A. , Kasson Matthew T. , Li You , Lynch Shannon , Mayers Chase , Musvuugwa Tendai , Roets Francois , Seltmann Katja C. , Six Diana , Vanderpool Dan , Villari Caterina 
Published: June 2020

AbstractOne of the main threats to forests in the Anthropocene are novel or altered interactions among trees, insects and fungi. To critically assess the contemporary research on bark beetles, their associated fungi, and their relationships with trees, the international Bark Beetle Mycobiome research coordination network has been formed. The network comprises 22 researchers from 17 institutions. This forward-looking review summarizes the group’s assessment of the current status of the bark beetle mycobiome research field and priorities for its advancement. Priorities include data mobility and standards, the adoption of new technologies for the study of these symbioses, reconciliation of conflicting paradigms, and practices for robust inference of symbiosis and tree epidemiology. The Net work proposes contemporary communication strategies to interact with the global community of researchers studying symbioses and natural resource managers. We conclude with a call to the broader scientific community to participate in the network and contribute their perspectives.
Efficiency of mitigation measures targeting nutrient losses from agricultural drainage systems: A review
Authors: Carstensen Mette Vodder , Hashemi Fatemeh , Hoffmann Carl Christian , Zak Dominik , Audet Joachim , Kronvang Brian 
Published: June 2020

AbstractDiffusive losses of nitrogen and phosphorus from agricultural areas have detrimental effects on freshwater and marine ecosystems. Mitigation measures treating drainage water before it enters streams hold a high potential for reducing nitrogen and phosphorus losses from agricultural areas. To achieve a better understanding of the opportunities and challenges characterising current and new drainage mitigation measures in oceanic and continental climates, we reviewed the nitrate and total phosphorus removal efficiency of: (i) free water surface constructed wetlands, (ii) denitrifying bioreactors, (iii) controlled drainage, (iv) saturated buffer zones and (v) integrated buffer zones. Our data analysis showed that the load of nitrate was substantially reduced by all five drainage mitigation measures, while they mainly acted as sinks of total phosphorus, but occasionally, also as sources. The various factors influencing performance, such as design, runoff characteristics and hydrology, differed in the studies, resulting in large variation in the reported removal efficiencies.
Impact of pharmacist counseling on health-related quality of life of patients with type 2 diabetes mellitus: a cluster randomized controlled study
Authors: Fajriansyah  , Iskandarsyah Aulia , Puspitasari Irma M , Lestari Keri 
Published: June 2020

Abstract
Purpose
The quality of life (QoL) of patients with type 2 diabetes mellitus (T2DM) is a measure of the successful outcomes of therapy. The program of management of chronic diseases “Program Pengelolaan Penyakit Kronis” (Prolanis) among patients with hypertension and T2DM is a new strategy of the Badan Penyelenggara Jaminan Sosial (BPJS), which is the Indonesian national health insurance system. Here, we analyzed the impact of pharmacist counseling interventions on health-related QoL (HRQoL) in Prolanis T2DM patients.

Methods
This cluster randomized controlled trial was designed to include two groups [control (n = 111) and intervention (n = 109) groups], and pre- and post-test procedures. The participants were Prolanis T2DM patients who attended four primary health-care centers (Puskesmas) in Makassar City, South Sulawesi, Indonesia from August 2017 to August 2018. The intervention group received systematic counseling for 6 months. The data were collected using the Bahasa Indonesia version of the European Quality of Life 5 Dimensions 5 Levels (EQ-5D-5 L) questionnaire and were analyzed using EQ-5D preference weight for each health state with the Indonesian EQ-5D-5 L value Set. Furthermore, the EQ-5D index and the EQ-5D VAS score were calculated and HbA1c levels were assessed.

Results
The change in the EQ-5D-5 L index score (post-pre) was 0.01 in the control group and 0.04 in the intervention group (P = 0.041). The change in the VAS score was −0.07in the control group (post-pre) and 2.66 in the intervention group (P = 0.000).

Conclusion
Pharmacist counseling may help improve the HRQoL of Prolanis T2DM patients.
Perfection of Perovskite Grain Boundary Passivation by Rhodium Incorporation for Efficient and Stable Solar Cells
Authors: Liu Wei , Liu Nanjing , Ji Shilei , Hua Hongfeng , Ma Yuhui , Hu Ruiyuan , Zhang Jian , Chu Liang , Li Xing’ao , Huang Wei 
Published: June 2020

AbstractOrganic cation and halide anion defects are omnipresent in the perovskite films, which will destroy perovskite electronic structure and downgrade the properties of devices. Defect passivation in halide perovskites is crucial to the application of solar cells. Herein, tiny amounts of trivalent rhodium ion incorporation can help the nucleation of perovskite grain and passivate the defects in the grain boundaries, which can improve efficiency and stability of perovskite solar cells. Through first-principle calculations, rhodium ion incorporation into the perovskite structure can induce ordered arrangement and tune bandgap. In experiment, rhodium ion incorporation with perovskite can contribute to preparing larger crystalline and uniform film, reducing trap-state density and enlarging charge carrier lifetime. After optimizing the content of 1% rhodium, the devices achieved an efficiency up to 20.71% without obvious hysteresis, from 19.09% of that pristine perovskite. In addition, the unencapsulated solar cells maintain 92% of its initial efficiency after 500 h in dry air. This work highlights the advantages of trivalent rhodium ion incorporation in the characteristics of perovskite solar cells, which will promote the future industrial application.
Förderung von unterrichtsbegleitendem Diagnostizieren von Schülervorstellungen durch Video- und Textvignetten
Authors: Hoppe Tobias , Renkl Alexander , Rieß Werner 
Published: June 2020

ZusammenfassungFachlich wenig anschlussfähige Schülervorstellungen können den Aufbau fachlich gültiger ökologischer Konzepte im Biologieunterricht beeinträchtigen, wenn Lehrkräfte diese im Unterrichtsverlauf nicht diagnostizieren und angemessen darauf reagieren. Unterrichtsbegleitende Diagnosen von Äußerungen der Schülerinnen und Schüler müssen häufig spontan („on-the-fly“) erfolgen. Es wäre wünschenswert, bereits angehende Lehrkräfte auf diese herausfordernde Aufgabe vorbereiten zu können. In einem experimentellen Prä-Posttest-Design (N = 36) wurden in dieser Studie Einflüsse auf den Erwerb von Fertigkeiten zur Diagnose von Schülervorstellungen untersucht. Hierfür wurden verschiedene Merkmale fallbasierter Lernsettings systematisch variiert (Video vs. Text/unterschiedliche Arten von Schülervorstellungen). Ein Training an Fallmedien erwies sich für bestimmte Diagnoseinhalte als effektiv im Vergleich zu einer Vermittlung diagnostischen Wissens ohne fallbasiertes Training. Unerheblich schien zu sein, ob als Fallmedium Video- oder Textvignetten verwendet wurden. Darüber hinaus zeigte sich, dass die Fertigkeiten zur Diagnose im Wesentlichen inhaltsspezifisch erworben werden. Die Ergebnisse werden hinsichtlich der Entwicklung von Fördermaßnahmen in der Lehrerbildung diskutiert.
The influence of hydrochar from biogas digestate on soil improvement and plant growth aspects
Authors: de Jager Megan , Röhrdanz Michael , Giani Luise 
Published: June 2020

AbstractHydrochar (HC), produced by hydrothermal carbonization, offers technical advantages over biochar (BC) produced by pyrolysis, and is suitable for soil amelioration, carbon sequestration, and enhanced plant growth. BC grain size has been shown to influence nutrient retention, microbial colonization and aggregate formation; however, similar research for HC is lacking. Pot trials were conducted to investigate the influence of HC grain size [coarse (6.3–2 mm), medium (2–0.63 mm) and fine (< 0.63 mm)], produced from biogas digestate, for soil improvement in three soils: loamy Chernozem, sandy Podzol, and clayey Gleysol, at a 5% HC application rate (w/w). All soils including two controls (with and without plants) were analysed for water holding capacity (WHC), cation exchange capacity (CEC), wet aggregate stability, pH, plant available nutrients (PO4–P, K and Nmin) and germination and biomass success using standard laboratory and statistical methods. Soil pH showed a compensatory shift toward the HC pH (7.2) in all soils over the course of the study. For example, the pH of the medium grained HC treatment for the Chernozem decreased from 7.9 to 7.2 and increased in the Podzol and Gleysol from 5.9 to 6.1 and 4.9 to 5.5, respectively. The nutrient-rich HC (2034 ± 38.3 mg kg−1 PO4–P and 2612.5 ± 268.7 mg kg−1 K content) provided only a short-term supply of nutrients, due to the relatively easily mineralized fraction of HC, which allowed for quick nutrient release. The pH and PO4–P effects were most pronounced in the fine grained HC treatments, with a ~ 87%, ~ 308% and ~ 2500% increase in PO4–P content in the Chernozem, Podzol and Gleysol, respectively, compared to the controls at the beginning of the study. The same trend was observed for the K and NH4+ content in the fine and medium grained HC treatments in all soils. No seed germination inhibition of Chinese cabbage was observed, with average germination rates > 50% in all soils. An effect on NO3− content was indeterminable, while there was little to no effect on biomass production, WHC, CEC and aggregate stability. In conclusion, the application of 5% fine grained HC significantly influenced the nutrient content over a short-term. However, the application rate was insufficient to substantially improve plant growth, nor to sustain a longer-term nutrients supply, regardless of grain size.
Paleocommunity composition, relative abundance, and new camerate crinoids from the Brechin Lagerstätte (Upper Ordovician)
Authors: Cole Selina R. , Wright David F. , Ausich William I. , Koniecki Joseph M. 
Published: June 2020

AbstractThe Brechin Lagerstätte of southern Ontario contains an exceptionally diverse and well-preserved Late Ordovician (Katian) crinoid fauna. We describe four genera and eight species of camerate crinoids from the Brechin Lagerstätte, including six new species. Consequently, the total diversity of the fauna now stands at 27 genera and 39 nominal species, thereby making it the most taxonomically diverse Ordovician crinoid fauna known. Taxa described include the diplobathrid Pararchaeocrinus kiddi new species and the monobathrids Glyptocrinus ramulosus Billings, 1856, Periglyptocrinus priscus (Billings, 1857a), Periglyptocrinus astricus new species, Periglyptocrinus kevinbretti new species, Periglyptocrinus mcdonaldi new species, Periglyptocrinus silvosus new species, and Abludoglyptocrinus steinheimerae new species. We summarize the taxonomic composition, diversity, and abundance distribution of all known crinoids from the Brechin Lagerstätte to better characterize the paleoecological structure and complexity of the community. We establish that the fauna is dominated by the subclass Pentacrinoidea, both in terms of abundance and species richness. In addition, we analyze species-level abundance data using Relative Abundance Distribution (RAD) models to evaluate the ecological complexity of the paleocommunity. We found that community structure of the Brechin Lagerstätte is best explained by an ecologically ‘complex’ RAD model, which suggests that species partitioned niches along multiple resource axes and/or the presence of multiple ecological ways of life. These results indicate that the Brechin Lagerstätte is significant not only for being the most taxonomically diverse Katian crinoid assemblage, but also for being an early ecologically complex fauna that developed in the wake of the Great Ordovician Biodiversification Event.UUID: http://zoobank.org/f86582ed-5db6-469E-befe-34b801f9a113