bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes
Authors: Huntley Melanie A. , Srinivasan Karpagam , Friedman Brad A. , Wang Tzu-Ming , Yee Ada X. , Wang Yuanyuan , Kaminker Josh S. , Sheng Morgan , Hansen David V. , Hanson Jesse E. 
Published: December 2019

Cortical circuit activity is shaped by the parvalbumin (PV) and somatostatin (SST) interneurons that inhibit principal excitatory (EXC) neurons and the vasoactive intestinal peptide (VIP) interneurons that suppress activation of other interneurons. To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons (http://research-pub.gene.com/NeuronSubtypeTranscriptomes). This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains.SIGNIFICANCE STATEMENTUnderstanding the basis of functional specialization of neuron subtypes and identifying drug targets for manipulating circuit function requires comprehensive information on cell-type-specific transcriptional profiles. We sorted excitatory neurons and key inhibitory neuron subtypes from mouse brains and assessed differential mRNA expression. We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. This analysis reveals numerous examples of neuron subtype-specific isoform usage with functional importance, identifies potential drug targets, and provides insight into the neuron subtypes involved in psychiatric disease. We also apply our analysis to two other relevant datasets for comparison, and provide a searchable website for convenient access to the resource.
Optimizing Low-Cost Genotyping and Imputation Strategies for Genomic Selection in Atlantic Salmon
Authors: Tsairidou Smaragda , Hamilton Alastair , Robledo Diego , Bron James E , Houston Ross D 
Published: December 2019

Abstract
Genomic selection enables cumulative genetic gains in key production traits such as disease resistance, playing an important role in the economic and environmental sustainability of aquaculture production. However, it requires genome-wide genetic marker data on large populations, which can be prohibitively expensive. Genotype imputation is a cost-effective method for obtaining high-density genotypes, but its value in aquaculture breeding programs which are characterized by large full-sibling families has yet to be fully assessed. The aim of this study was to optimize the use of low-density genotypes and evaluate genotype imputation strategies for cost-effective genomic prediction. Phenotypes and genotypes (78,362 SNPs) were obtained for 610 individuals from a Scottish Atlantic salmon breeding program population (Landcatch, UK) challenged with sea lice, Lepeophtheirus salmonis. The genomic prediction accuracy of genomic selection was calculated using GBLUP approaches and compared across SNP panels of varying densities and composition, with and without imputation. Imputation was tested when parents were genotyped for the optimal SNP panel, and offspring were genotyped for a range of lower density imputation panels. Reducing SNP density had little impact on prediction accuracy until 5,000 SNPs, below which the accuracy dropped. Imputation accuracy increased with increasing imputation panel density. Genomic prediction accuracy when offspring were genotyped for just 200 SNPs, and parents for 5,000 SNPs, was 0.53. This accuracy was similar to the full high density and optimal density dataset, and markedly higher than using 200 SNPs without imputation. These results suggest that imputation from very low to medium density can be a cost-effective tool for genomic selection in Atlantic salmon breeding programs.
Aerosol optical properties and direct radiative effect over Gobabeb, Namibia
Authors: Adesina Joseph A. , Piketh Stuart J. , Formenti Paola , Maggs-Kölling Gillian , Holben Brent N. , Sorokin Mikhail G. 
Published: December 2019

Atmospheric aerosols contribute significantly to the uncertainty in radiative forcing effects that influence the climate and pose a significant health risk to humans. The climatic implications of aerosols are dependent on many variables, including aerosol size, shape, chemical composition, and position in the atmospheric column. The radiative impact of aerosols transported over the west coast of southern Africa has been found, in particular, to be complicated by the aforementioned aerosol properties. This study investigated the columnar optical properties of aerosols over Gobabeb, Namibia (23.56oS, 15.04oE, 400 m asl) using sunphotometer data between December 2014 and November 2015. Aerosol mean optical depth AOD500 had its maximum and minimum values in 2015 August (0.37±0.30) and June (0.06±0.02), respectively. The Angström parameter was mostly above unity during the study period and indicated the prevalence of fine particles for the most part of the year with maximum and minimum values observed in August 2015 (1.44±0.19) and December 2014 (0.57±0.19), respectively. The columnar water vapor was highest in January (2.62±0.79) and lowest in June (0.76±0.27). The volume size distribution showed the fine particles having a mean radius of about 0.16 μm and the coarse mode had variation in sizes with a radius ranging between 3 μm and 7 μm. The single scattering albedo at visible wavelengths ranged between 0.87 and 0.88. The phase function was high at small angles but minimum at about 140o in all seasons. The radiative forcing showed a heating effect in all seasons with maximum and minimum in winter (9.41 Wm-2) and autumn (3.64 Wm-2), respectively. Intercomparison of the sunphotometer data with the Moderate Resolution Imaging Spectroradiometer (MODIS) showed that the satellite sensor overestimates the aerosol loading compared to the ground-based sunphotometer measurements. Both sets of observations were better correlated during the spring and winter seasons than for summer and autumn.
The Effectiveness of a Comprehensive Intervention on Word Problem Solving for Elementary School Students with ADHD: POVM + Schema Based Word Problem Solving
Authors: KAHVECİ Gül , ALTUN Hasan 
Published: December 2019

When core mathematic instruction is not enough to address skill deficits of students with ADHD, more intensive interventions are required to support student learning and comprehensive interventions with strong instructional components may use to help improve achievement of students with mathematics difficulties. As individual components are found effective according to the literature, a combination of interventions may be used to develop a comprehensive treatment to enhance outcome for students with wide-ranging academic deficits in ADHD. This study aimed to extend the use of VBI by using POVM, schema based-word problem solving method and peer tutoring to teach change, group, and compare type addition-subtraction word problem solving to students with ADHD. The instruction was anchored in use of concrete representations of schema to model conceptual understanding of word problem solving. The video presentation of the instruction via POVM allows for development of procedural knowledge as participants can view instruction of problem-solving steps. A single-case multiple probe across participants, experimental design was used with three participants. Participants were given a laptop connected to headphones. The video was preloaded on the laptop and participants started and stopped the intervention independently. After watching the video, participants completed the three different types of word addition and subtraction problems independently. Sessions were monitored and videotaped by the author to ensure videos were viewed in their entirety and at least two weeks after completion of the intervention, participants were given a maintenance assessment. All participants were successful and shared that they enjoyed learning about word problem solving using the video instruction, supporting the social validity of this intervention.
Classificação Espectral de Fitofisionomias em Área de Floresta Tropical Utilizando Dados do Sensor Aster
Authors: Nunes Gustavo Manzon , De Souza Filho Carlos Roberto , Ferreira Laerte Guimarães , Vicente Luiz Eduardo , Vilani Maricéia Tatiana 
Published: December 2019

Este artigo pretende avaliar a capacidade dos dados gerados pelo sensor Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER)/Terra, na discriminação de fitofisionomias existentes na Reserva de Desenvolvimento Sustentável Amanã (RDSA). Os dados ASTER analisados incluem os intervalos espectrais do visível (0.52-0.69 μm), infravermelho próximo (0.78-0.86 μm) e infravermelho de ondas curtas (1.60 a 2.43 μm), sendo que nas bandas destes intervalos foram aplicadas técnicas de classificação espectral adaptadas para os dados deste sensor como Spectral Angle Mapper (SAM), Mixture Tuned Matched Filtering (MTMF), além do NDVI. Através da técnica SAM foi possível a discriminação de seis fitofisionomias predominantes na RDSA. Através da técnica MTMF, que envolve um algoritmo de classificação mais robusto, informações equivalentes foram obtidas. Foi possível ainda a associação e detecção dos padrões espectrais da cobertura vegetal, mostrando a estreita relação com o índice NDVI. Palavras-chave: Mapeamento. Reserva de Desenvolvimento Sustentável Amanã. Vegetação. Abstract This article aims to evaluate the data capacity created by a sensor named Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER)/Terra, in the phytophysiognomies description of Amanã Sustainable Development Reserve (RDSA). The ASTER data analyzed include the spectral intervals of visible (0.52-0.69 μm), near-infrared (0.78-0.86 μm) and shortwave infrared (1.60 to 2:43 μm), wherein these intervals bands were applied the spectral classification techniques adapted to the data from this sensor as Spectral Angle Mapper (SAM), Mixture Tuned Matched Filtering (MTMF) plus NDVI. By SAM technique was possible to distinguish six predominant phytophysiognomies in the RDSA. By MTMF technique that involves a more robust classification algorithm, equivalent information was obtained. It was also possible to associate and detect spectral patterns of vegetation, showing the close relationship with the NDVI index. Keywords: Amanã Sustainable Development Reserve. Mapping. Vegetation.
Study of the environmental ecological environment: perception of children and young people of the schools from Obligado District, Department of Itapúa
Authors: Dickel Vanesa Juliet , Bonnin Juan Jose 
Published: December 2019

For proper management and care of the environment in a citizenry, the implementation of education from an early age is necessary. Environmental education from its beginnings, when only general concepts about the environment were talked about, until today, with the influence of sustainable development, was intended to help the proper perception of the environment in people, for which we must become aware, besides transmitting to children and young people good practices that influence their daily lives and that constitute a way of life. From the study carried out, it is intended to reflect the perspective in knowledge, management, sensitivity and behavior relating it to environmental issues. Through the use of a mixed type survey, the sample under study was questioned about the level of knowledge about the environment resulting in regular knowledge, at which water and air were presented as an aspect of greater interest as a component environmental. Aware that there are environmental problems at different scales, more specifically, at regional level, environmental pollution is categorized in a first order of importance. Information about the environment is perceived to a greater extent through the media and even to a greater extent through television.
Germination of five weed species of Convolvulaceae family under the effect of temperature
Authors: Labonia Victor Domiciano de Silos , Presoto Jéssica Cursino , Andrade Jeisiane de Fátima , Carvalho Saul Jorge Pinto de , Victoria Filho Ricardo 
Published: December 2019

Seeds of several weed species have distinct development when germinating under different conditions of temperature, promoting variation on the management system. Thus, this work was carried out with the objective of evaluating the influence of temperature on the germination of five weed species of Convolvulaceae family, commonly known as morning glory. The work was performed in termogradient table and constituted by five independent experiments, divided by species, in a factorial combination of nine treatments (temperatures) and two seed dormancy breaking conditions (with or without acid scarification). The weed species were: Ipomoea triloba, I. hederifolia, I. quamoclit, I. nil and Merremia cissoides. Nine temperature intervals between 15 and 35ºC were evaluated, under 8 hours of daily photoperiod. Experimental design adopted was totally randomized with four replicates. Percentage of germination was evaluated daily; the speed of germination index was calculated for the species. Generally, it was evident that temperatures lower than 17,2 ºC reduced significantly germination of all species, inhibiting germination of I. quamoclit. Species demonstrated capacity of germinating on temperatures from 20ºC to 35ºC. Acid scarification of seeds with sulfuric acid was able of increasing significantly the percentage of seed germination.
THE EFFECT OF WORKING CAPITAL MANAGEMENT ON FINANCIAL PERFORMANCE AND OPERATIONAL CASH FLOWS OF COMPANIES ACCEPTED IN TEHRAN SECURITIES EXCHANGE
Authors: Asghar Sameni Ali , Fakour Razieh 
Published: December 2019

Purposes: Working capital management can have a huge impact on financial performance and operational cash flows. In this research, the effect of working capital management components on financial performance and operating cash flows have been investigated.
Methodology: The data used in this study are financial statements of companies listed in Tehran securities exchange for the period 2007 to 2011.
Results: The difference between sales and operating profit as a benchmark for measuring performance and the difference between operating cash flow and operating profit as a measure of operating cash flow has been used. Regression results show that there is no meaningful relationship between the components of working capital management with financial performance and operating cash flow.
Implications/Applications: Net income represents the change in a business's financial circumstances incurred through that business choosing to run its revenue-producing operations for one specific time period. Because the business cannot choose to run its revenue-producing operations without incurring expenses while doing so, net income is equal to revenues minus expenses. Expenses are often divided up into additional categories for ease of comprehension. Revenues minus cost of sales is equal to gross profit; gross profit minus operating expenses is equal to operating profit.
Novelty/Originality: The novelty of this study is a balance between current assets and current liabilities, as well as maintaining a balance between profitability and liquidity which can serve a great purpose in the economy.
LEGAL STATUS OF PLATFORM WORKERS IN RUSSIA: RIGHT ON UNEMPLOYMENT AND SOCIAL ASSISTANCE
Authors: Sh. Davletgildeev Rustem , R. Klimovskaya Lenara 
Published: December 2019

Purposes: Russian Federation as many other States experience the growth of the “gig economy”. The number of people working via platforms grows with every year. As a result, it brings up a new form of employment. Consequently, national law and social security systems have to adapt to new challenges in order to provide from one hand, efficient regulation of such relations, from another hand – to protect the rights of crowd-workers.
Methodology: Russian legislators introduced in 2013 the new concept of “distance work”, which partially covers platform workers. Since late 2019 new regulations concerning non-registered self-employed persons will come into force. Nonetheless, the discussion on the place of crowd-workers remains to be open within practitioners and scholars and still shows the uncertainty.
Result: In this paper, we tried to determine the legal status of platform workers and identify their place within the system of Labour and Social Security Law with a detailed focus on access to Unemployment Benefit and Social Assistance.
Implications/Applications: As a general rule, digital platforms do not impose concrete requirements for the crowd-worker, for instance as the obligation of having registered status as individual entrepreneurship. In this case, any physical person showing the will to work can register with a platform and provide services.
Novelty/Originality: We will try to give the legal definition and to find out the recognition of so-called Platform Workers within the national Labour Law. After the research will be focused on a social cluster: the right of Platform Workers to access to Unemployment Benefit and Social Assistance.
PENGARUH BAYANGAN TERHADAP OUTPUT TEGANGAN DAN KUAT ARUS PADA PEMBANGKIT LISTRIK TENAGA SURYA (PLTS)
Authors: Edwin Hattu P D , Jhon Wabang A , Ambros Tuati , Aris Palinggi 
Published: December 2019

Electrical energy is a very important requirement for the community, along with the development of the era and technological advances that are urgently needed, the need for electrical energy is very large, while the source of electricity that is currently being used still uses energy derived from fossil fuels. As we know that the source of energy derived from fossils is very limited, therefore other energy sources are sought or we are more familiar with renewable energy, one of which is the energy source that comes from the sun, which is better known as solar cell. The electricity from this solar cell is very dependent on sunlight which must illuminate the solar panels so that solar energy can be converted into electrical energy. The output from these solar panels is in the form of voltage and electric current. Some factors that can affect the amount of output or output voltage of electric current in PLTS is, temperature, shadow, (cloud condition, and surrounding environment), and wind speed. Therefore, the purpose of this research is to find out how much the shadow effect on the output voltage and electric current produced by PLTS. It is expected that this research can increase the knowledge of energy derived from the sun in this case the solar cell and know the effect of the shadow on the output voltage and electric current from solar panels.The results showed that there was a shadow effect on voltage reduction and current strength in the PLTS system, namely the 10% shadow area and 12.44 volt DC solar panel current and 2.54 amperage, 100% area covering the voltage output panel and the current of solar panels 12.10 volt DC and 0.22 amperage. The area of the shadow that covers the solar panel affects the output voltage and the strong current of the battery that is the area of the shadow 10% voltage and strong current battery 12.35 volt DC and 18.54 amper, 100% area cover the output panel voltage and strong current battery 11.90 volt DC and 13.85 amperes The shadow area covering the solar panels influences the output voltage and current strength of the inverter, namely the area of the shadow 10% voltage and 226.4 volt AC inverter current and 0.97 amperage, 100% covering the output voltage panel and 220.2 volt AC and 0.66 amperage current.
Keywords: Electrical energy, Solar cell, Shadow (cloud condition)
Total Knee Bartonella henselae Infection: An Unusual Manifestation of Cat Scratch Disease
Authors: Haimes Mark A. , Nelms Nathaniel J. 
Published: December 2019

Case:
This is the first clinical report of periprosthetic total joint infection caused by Bartonella henselae. A 65-year-old woman developed an acutely painful total knee 3 weeks after a cat scratch. Serial joint aspirations and tissue cultures failed to identify any organism. Diagnosis was performed with polymerase chain reaction analysis. She underwent a 2-stage revision with successful symptom resolution.

Conclusions:

Bartonella is an unusual cause of total knee infection requiring alternative techniques for diagnosis because cultures are unlikely to be definitive.
Minimally Invasive Fixation for Spinopelvic Dissociation: Percutaneous Triangular Osteosynthesis with S2 Alar-Iliac and Iliosacral Screws
Authors: El Dafrawy Mostafa H. , Shafiq Babar , Vaswani Ravi , Osgood Greg M. , Hasenboehler Erik A. , Kebaish Khaled M. 
Published: December 2019

Case:
Traumatic U- and H-type sacral fractures are often unstable, causing spinopelvic dissociation. We describe a minimally invasive approach that allows percutaneous spinopelvic fixation of unstable H-type sacral fractures using a triangular osteosynthesis construct with S2 alar-iliac screws. We present the case of a patient with traumatic lumbopelvic dissociation who underwent percutaneous S2 alar-iliac and iliosacral screw fixation.

Conclusions:
Combined percutaneous S2 alar-iliac and iliosacral screw fixation is a safe option for spinopelvic fixation and avoids the soft-tissue compromise of open approaches. The triangular osteosynthesis construct provides adequate pelvic anchor points to allow immediate weight-bearing.
New Functional Possibilities of Fire Detectors for Residential and Industrial Rooms
Authors: Kitikov V. O. , Ternov E. V. , Danilenko A. V. , Mukhurov N. I. , Denisyuk S. V. 
Published: December 2019

The relevance of early detection of fire signs is quite obvious because due to the necessary measures for evacuating of people and material values, disconnecting the electrical equipment and extinguishing the fire at the time of the onset of fire or passive smoldering, human casualties can be completely avoided and economic losses can be minimized.A graphical representation of fire detectors' the classification in the form of a generalized scheme using all the main classification features, their advantages and disadvantages is given. The optimal areas for the use of detectors depending on the fire load are determined. The effectiveness of combined fire detectors' use, equipped in addition to traditional smoke and heat sensors with gas sensors, as an integrated approach to the organization of control over protected objects is shown.The results of development of highly sensitive two-zone sensor with sensitive elements based on iron oxide films for detecting the release of explosive and poisonous gases in the initial stage of decay before the formation of ignition conditions are presented. The use of gas sensors that respond to hazardous gases in the environment significantly reduces the risk of death due to carbon monoxide poisoning.