bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Characteristics of Influenza-Like Illness Management in Japan
Authors: Tsuzuki Shinya , Yoshihara Keisuke 
Published: December 2019

Abstract
Background: This study aimed to make a quantitative assessment of the management of influenza-like illnesses in Japanese healthcare settings. Methods: We analysed participants’ healthcare-seeking behaviour and physicians’ practice in January 2019 using an online survey of 200 households in Japan. Quality of life score, quality-adjusted life years lost, the duration of symptoms, and the duration of absence from work were compared between influenza group and influenza-like illness group with one-to-one propensity score matching. Missing data were imputed using multiple imputation. Results: In total, 261 of the 600 (43.5%) participants had at least one episode of influenza-like illness during January 2019. Of these, 194 (75.5%) visited healthcare facilities, 167 (86.1%) within 2 days of onset of symptoms. A total of 169 out of 191 (88.5%) received a rapid influenza diagnostic test and 101 were diagnosed with influenza, of whom 92.2% were treated with antivirals. The median quality-adjusted life-years lost was 0.0055 (interquartile range, IQR 0.0040–0.0072) and median absence from work for a single episode of influenza-like illness was 2 days (IQR 1–5 days). Conclusions: In Japan, most people with influenza-like illnesses visit healthcare facilities soon after symptoms first occur and receive a diagnostic test. Those with influenza are usually treated with antivirals. Absence from work was longer for influenza than other similar illnesses.
Reference values of fat mass index and fat-free mass index in healthy Spanish adolescents.
Authors: Durá-Travé Teodoro , Gallinas-Victoriano Fidel , Chueca-Guindulain María , Berrade-Zubiri Sara , Malumbres-Chacón María , Moreno-González Paula 
Published: December 2019

Abstract
Background. Body mass index (BMI) does not allow to discriminate the composition of the different body compartments. The aim of this study is to elaborate reference values ​of the fat mass index (FMI) and fat-free mass index (FFMI) in healthy adolescents using anthropometric techniques in order to be available as reference standards in daily clinical practice. Methods. Transversal study in 940 healthy Caucasian adolescents (370 males and 570 females), aged 10.1 to 14.9 years. Weight, height and skinfold thickness were registered, and BMI, percentage of total boy fat, FMI and FFMI, and FMI and FFMI percentiles were calculated. Results. In males a significant increase in the FFMI is observed, and the percentage of total body fat and FMI significantly decreased. In contrast, in females the percentage of body fat mass, FMI and FFMI significantly increased. Except for the 10 years, FMI was higher (p<0.05) in females in all ages. FFMI was higher (p<0.05) in males in all ages. FFMI and FMI percentiles for healthy adolescents (both sexes) categorized by age are displayed. Conclusions. Reference values of FMI and FFMI would be a very useful instrument for the diagnosis and analysis of body composition changes during the treatment of childhood obesity.
Efficacy, safety, and tolerability of combined pirfenidone and N-acetylcysteine therapy: A systematic review and meta-analysis
Authors: Author) Hanyu Shi(Former Corresponding , Yin Dawei , Bonella Francesco , Kreuter Michael , Oltmanns Ute , Li Xuren , Peng Shouchun , Author) Luqing Wei(New Corresponding 
Published: December 2019

Abstract
Background: While antifibrotic drugs significantly decrease lung function decline in idiopathic pulmonary fibrosis (IPF), there is still an unmet need to halt disease progression. Antioxidative therapy with N-acetylcysteine (NAC) is considered a potential additional therapy that can be combined with antifibrotics in some patients in clinical practice. However, data on the efficacy, tolerability, and safety of this combination are scarce. We performed a systematic review and meta-analysis to appraise the safety, tolerability, and efficacy of the combination compared to treatment with pirfenidone alone.
Methods: We systematically reviewed all the published studies with combined pirfenidone (PFD) and NAC (PFD+NAC) treatment in IPF patients. The primary outcomes referred to decline in pulmonary function tests (PFTs) and the rates of IPF patients with side effects.
Results: In the meta-analysis, 6 studies with 319 total IPF patients were included. The PFD+NAC group was comparable to the PFD alone group in terms of the predicted forced vital capacity (FVC%) and predicted diffusion capacity for carbon monoxide (DLco%) from treatment start to week 24. Side effects and treatment discontinuation rates were also comparable in both groups.
Conclusion: This systematic review and meta-analysis suggests that combination with NAC does not alter the efficacy, safety, or tolerability of PFD in comparison to PFD alone in IPF patients.
Virtual Reality Social Prediction Improvement and Rehabilitation Intensive Training (VR-SPIRIT) for paediatric patients with congenital cerebellar diseases: study protocol of a randomized controlled trial.
Authors: Butti Niccolò , Biffi Emilia , Genova Chiara , Romaniello Romina , Redaelli Davide Felice , Reni Gianluigi , Borgatti Renato , Urgesi Cosimo 
Published: December 2019

Abstract
Background: Patients with cerebellar malformations exhibit not only movement problems, but also important deficits in social cognition. Thus, rehabilitation approaches should not only involve the recovery of motor function but also of higher-order abilities, such as processing of social stimuli. In keeping with the general role of the cerebellum in anticipating and predicting events, we used a VR-based rehabilitation system to implement a social cognition intensive training specifically tailored to improve predictive abilities in social scenarios (VR-Spirit). Methods: The study is an interventional randomized controlled trial that aims to recruit 42 children, adolescents and young adults with congenital cerebellar malformations, randomly allocated to the experimental or active control group. The experimental group is administered the VR-Spirit, requiring the participants to compete with different avatars in the reaching of recreational equipment and implicitly prompting them to form expectations about their playing preference. The active control group participates to a VR-training with standard games currently adopted for motor rehabilitation. Both trainings are composed by 8 45-minute sessions and are administered in the GRAIL VR-Lab (Motekforce Link, NL), an integrated platform that allows patients to move in natural and attractive VR environments. An evaluation session in VR with the same paradigm used in the VR-Spirit but implemented in a different scenario is administered at the beginning (T0) and at the end (T1) of the two trainings. Moreover, a battery of neurocognitive tests spanning different domains are administered to all participants at T0, T1 and in a follow-up session after two months from the end of the two trainings (T2). Discussion: This study offers a novel approach for rehabilitation based on specific neural mechanisms of the cerebellum. We aim to investigate the feasibility and efficacy of a new intensive social cognition training in a sample of Italian patients aged 7-25 years with congenital cerebellar malformations. We expect that VR-Spirit could enhance social prediction ability and indirectly improve cognitive performance in diverse domains. Moreover, through the comparison with a VR-active control training we aim to verify the specificity of VR-Spirit in improving social perception skills.
Hopeful Acts in Troubled Times: Thinking as interruption and the poetics of nonconforming criticism
Authors: Damian Martin Diana 
Published: December 2019

In his work titled ‘Dance Curves: On the Dances of Palucca’ (1926), Wassily Kandisky translates two postures of the German Expressionist choreographer Gret Palucca from photographs into line drawings. The drawings are a study, but they are neither pictorial, nor straightforwardly representational. Staging an encounter between Dance Curves and Hannah Arendt’s investigation into thinking as both an interrupted and interruptive activity, this essay argues for a poetics of appearance as it is constituted by nonconforming acts of critique.Negotiating conflicts that shape a politics of recognition for criticism which deliberately or implicitly refutes utility, I articulate a process of appearance of meaning with differential relation to modernist concerns for interpretation, dissenting from rationalist and objectivist traditions that have dominated theatre and performance criticism since the Enlightenment. What happens when I disavow the drawings from the images, remove them from the source? Perhaps in such a place, we might find critique as a process of deliberately mishandled translation, as an occupation of an idea shifted elsewhere, as a displacement of meaning. Appearance shapes itself around slippages of attention that depart from the work of performance.In this essay, I turn to how these slippages fold outwards from the encounter, to the political nexus between performance and its world. In Arendt, I locate a means through which forms of thinking rendered as criticism constitute a resistant poetics to normative modes of paying attention, operating beyond what Bojana Kunst calls ‘the ready-made possibilities of discourse’ (2015, 13) under neoliberalism, that is, the ‘pre-established models of criticality and reflexivity’ to which art and artistic subjectivity often partake (ibid.)
Efectividad de la Urtica Dioica (ishanga) en el tratamiento de asma infantil
Authors: Leon Ivonne 
Published: December 2019

Objetivo: Determinar la efectividad de la Urtica Dioica (Ishanga) en el tratamiento de Asma en niños de 2 a 4 años que acuden al Hospital Amazónico Ucayali 2018. Métodos: El trabajo fue de tipo experimental-prospectivo longitudinal; se trabajó con 2grupos de muestras (10 niños con asma para el grupo experimental y 10 para el grupo control). Para la recolección de datos se usó: la ficha de asma y la lista de cotejo. Para el análisis descriptivo de los datos estadísticos se realizó el análisis de Chi-cuadrado. Resultados: Los tipos de asma el mayor porcentaje 40% de niños del grupo experimental presentaron asma de tipo leve y en el grupo control el 50%, después de la administración de la Urtica Dioica (Ishanga) el 80% del grupo experimental no presento ningún tipo de asma y en el grupo control aumentaron de un 50% a un 60% de asma en los niños. El análisis estadístico de los datos deja ver que existe una diferencia significativa en la respuesta clínica entre ambos grupos, dado un valor de chi-cuadrado de 3.84 con un valor de p= 0.05, con lo cual se acepta la hipótesis alterna que afirma: “La Urtica Dioica (Ishanga) es efectiva para el tratamiento del asma infantil en niños de 2-4 años. Conclusión: La infusión de Urtica Dioica (Ishanga) en dosis de 100/kg Mg. durante 6 meses reduce el número de exacerbaciones, mejora la función pulmonar a largo plazo y previene el desarrollo de una limitación crónica funcional.
Etnobotani Tanaman Kelor (Moringa oleifera Lam.) di Desa Kedungbulus Gembong Pati
Authors: Dhea Dani Brintan Yonaka , Wahidah Baiq Farhatul , Syaifudin Andang 
Published: December 2019

<em>The potential of Moringa tree related to health properties is still not fully utilized by the people in Pati. Mrs. Muryati, a resident of Kedungbulus Village, Gembong Subdistrict, Pati, was one of the residents who was moved to campaign for the use of Moringa leaves. The purpose of this study was to determine public perceptions about the potential of Moringa plants in the village of Kedungbulus Gembong Pati. This research uses survey methods which include: literature study, field observations, interviews using questionnaires, semistructure interview techniques and using random sampling techniques and purposive sampling. Random sampling sampling from the community taken randomly, while purposive sampling sampling from community leaders such as informants of production houses, village heads, shamans etc. The results obtained from the relationship between community and Moringa plants are explained from interviews with the public perception of Moringa plants.</em>
Uso de atmósferas controladas para conservar la calidad de tuna roja (Opuntia ficus-indica (L.)) mínimamente procesada
Authors: Alba-Jiménez Jimena Esther , Chavéz-Servia José L. , Martínez Armando J. , Urrutia-Hernández Thania A. , Cruz-Huerta Elvia , Aquino-Bolaños Elia Nora 
Published: December 2019

Introducción: México es el principal productor de tuna en el mundo, con aproximadamente 400,000 toneladas por año. Sin embargo, es un fruto muy perecedero (9 a 15 días a temperatura ambiente), además la presencia de espinas en su pericarpio reduce su consumo y limita su comercialización causando así pérdidas en su producción. Por lo tanto, es necesario proponer alternativas de consumo como producto mínimamente procesado (PMP) y el uso de atmósferas controladas (AC) para alargar su vida poscosecha.Método: En rodajas de tuna roja minímamente procesada se aplicaron diferentes tratamientos de AC (AC1: 5% O2 + 95% N2, AC2: Aire + 10% CO2, AC3: 10% CO2 + 5% O2 + 85% N2 y aire como control) durante 16 días de almacenamiento a temperatura de 5 ºC. Cada cuatro días se analizó la concentración de azúcares totales (AT), sólidos solubles totales (SST), pH, actividad de polifenol oxidasa (PFO), pérdida fisiológica de peso (PFP) y calidad visual (CV). Resultados: Los tratamientos en AC presentaron menor PFP. El tratamiento con 10% CO2 + 5% O2 + 85% N2 contribuyó a la retención de la CV (6.24), PFP (9%) y pH (5.34), y el tratamiento con 10% CO2 + Aire en el contenido de azúcares (176.21 mg Glucosa mL-1); mientras que los (SST) y la actividad de PFO no presentó diferencia entre los tratamientos. Por su parte, el análisis multivariado de componentes principales (CP) explicó el 85% de la varianza en dos componentes para seis variables fisicoquímicas de los frutos de tuna.Conclusión: El uso de AC prolongó la vida poscosecha de los frutos de tuna roja mínimamente procesados hasta por 16 días de almacenamiento.
High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through the Activation of Akt
Authors: Jin Xiaoxia , Wei Yingze , Liu Yushan , Chen Yali , Zhao Bin , Huang Jieyu , Yu Haiyan , Li Chunsun 
Published: December 2019

Background and Purpose:Although limited by side effects and development of resistance, doxorubicin still represent the most common chemotherapy for breast cancer. Thus, the identification of critical molecules to alleviate doxorubicin resistance is crucial. Here, we provide a molecular rationale for the breast cancer patients potentially benefitting from doxorubicin based on the expression levels of SIRT1, a identified member of longevity genes.Methods:SIRT1-overexpressed and SIRT1-knockdown breast cancer cells were established to investigate the functions of SIRT1 in regulating doxorubicin resistance both in vitro and in vivo. Cell proliferation was analyzed via CCK8 assay, cell apoptosis was studied by TUNEL anslysis. Molecule interaction was analyzed through co-immunoprecipitation and immunofluorescence techniques. Sensibility to doxorubicin was assessed in vivo through nude mice tumorigenicity experiment.Results::First, SIRT1 was found higher-expressed in breast cancer doxorubicin-resistant cells MCF-7/ADR than that in doxorubicin- sensitive cells MCF-7. Moreover, SIRT1-knockdown MCF-7/ADR cells showed higher susceptible to doxorubicin both in vitro and in vivo models, whereas overexpressing of SIRT1 obviously inhibited this phenotype. Accordingly, SIRT1 was found interacted with Akt, consequently promoted the activity of Akt in MCF-7/ADR cells in vitro and positively correlated with the expression of P-Akt in vivo. Reversion the activity of Akt partially downturned the doxorubicin-resistant effects mediated by SIRT1.Conclusion:This investigation suggested the value of SIRT1 as biomarker of response to doxorubicin, leading to the development of new tools for the management of breast cancer patients.
Mast Cells as a Double Edged Sword in Immunity: Disorders of Mast Cell Activation and Therapeutic Management. Second of Two Parts
Authors: Magrone Thea , Magrone Manrico , Jirillo Emilio 
Published: December 2019

:Mast cells (MCs) bear many receptors which allow them to respond tAs far as treatment of MC-derived diseases is concerned, allergen immunotherapy as well as other attempts to reduce MC-activation will be outlined according to the recent data. Finally, in agreement with current literature and our own data polyphenols have been demonstrated to attenuate type I allergic reactions and contact dermatitis in response to nickel. The use of polyphenols in these diseases will be discussed also in view of MC involvement.o a variety of exogenous and endogenous stimuli. However, MC function is dual since they can initiate pathological events or protect the host against infectious challenges.:The role of MCs in disease will be analyzed in a broad sense, describing cellular and molecular mechanisms related to their involvement in auto-inflammatory diseases, asthma, autoimmune diseases and cancer. On the other hand, their protective role in the course of bacterial, fungal and parasitic infections will also be illustrated.:Mast cells (MCs) bear many receptors that allow them to respond to a variety of exogenous and endogenous stimuli. However, MC function is dual since they can initiate pathological events or protect the host against infectious challenges.
Development of Polymeric Nanocarriers for Brain Targeted Delivery of Atorvastatin: A Quality-By-Design Approach
Authors: Martins Guilherme A.G. , Murakami Fabio S. , Oliveira Mauro S. , Furian Ana F. , Treichel Helen , Mainardes Rubiana M. , Marcano Rossana G.D.J.V. , Bernardi Larissa S. , Oliveira Paulo R. 
Published: December 2019

Objective:
Atorvastatin (ATV) is effective in reducing total cholesterol and low-density lipoprotein
levels. Furthermore, it produces pleiotropic effects in neurodegenerative conditions such as
Parkinson's, Alzheimer's, and epilepsy. However, due to the effective defense system of the central
nervous system (CNS), the development of new medicines for clinical conditions has proven difficult.
In this context, nanotechnology was applied as a promising solution to promote drug vectorization to
the brain.

Methods:
The solvent emulsification-diffusion method was used to develop nanoparticles (NPs) based
on polylactic acid and coated with polysorbate 80 containing ATV. Quality-by-Design (QbD) was
used in the optimization of nanoparticles production through the application of the experimental design
Box-Behnken Design.

Results:
After optimizing the independent factors including sonication time, surfactant concentration
and surfactant volume, the NPs presented physicochemical characteristics such as entrapment efficiency
of 86.4 ± 2.4%, mean size of 225.2 ± 4.8 nm, and zeta potential of -14.4 ± 0.36 mV. In the in vitro
release study, approximately 20% of the encapsulated ATV was released.

Conclusion:
The application of QbD was very useful in demonstrating its applicability in the nanotechnological
pharmaceutical area for controlling and predicting the influence of the variables in the
production of NPs. The NPs developed in this study presented adequate physicochemical characteristics,
which is promising for future in vivo studies.

The physicochemical characteristics included entrapment efficiency of 86.4 ± 2.4%, mean size of
225.2 ± 4.8 nm, and zeta potential of -14.4 ± 0.36 mV. In the in vitro release study, approximately
20% of the encapsulated ATV was released. The application of QbD was very useful in demonstrating
its applicability in the nanotechnological pharmaceutical area for controlling and predicting the influence
of the variables in the production of NPs. The NPs developed in this study presented adequate
physicochemical characteristics, which is promising for future in vivo studies.
Quando o velho encontra o novo: uma análise da descentralização proposta com as Subprefeituras nas cidades de São Paulo e Rio de Janeiro
Authors: Grin Eduardo José , Lameirão Camila Romero 
Published: December 2019

Teoricamente o artigo discute se inovações institucionais em estruturas governamentais podem alimentar e serem apoiadas por práticas políticas tradicionalmente existentes. Empiricamente analisa-se a descentralização, por meio da implantação das Subprefeituras nas cidades do Rio de Janeiro e São Paulo. Mostra-se como gradativamente as Subprefeituras transformaram-se em recurso político para os Prefeitos constituírem sua política de alianças na Câmara Municipal. O pluralismo e o institucionalismo histórico são o suporte teórico deste estudo qualitativo baseado em most-different cases: enfatiza-se a variação sobre as variáveis independentes e busca-se evitar a variação sobre os resultados. O objetivo é analisar a semelhança da forma como as Subprefeituras serviram para os prefeitos paulista e carioca construírem suas coalizões políticas dominantes. Conclui-se que a descentralização nem sempre é virtuosa, pois em contextos onde vereadores têm influência e controle sobre regiões da cidade existem incentivos à manutenção de práticas políticas institucionalizadas de patronagem governamental para obter apoio parlamentar.
Pengaruh Program Kampung UKM Digital terhadap Omzet Penjualan (Studi Kasus UKM Batik Kayu Krebet, Pajangan, Bantul)
Authors: Yunadi Ahmad , Ardiyanti Wiwik 
Published: December 2019

<p>Penelitian ini bertujuan untuk mengetahui perbedaan omzet penjualan sebelum dan sesudah menggunakan program kampung UKM digital pada Sanggar Batik Kayu Krebet Sendangsari Pajangan Bantul yang mendapatkan program kampung UKM digital dari Pemerintah Daerah Bantul. Sanggar Batik Kayu di dusun Krebet yang mendapatkan program kampung UKM digital sebanyak 5 sanggar. Omzet penjualan yang dipakai adalah omzet yang didapatkan melalui pemasaran konvensional dan <em>online</em> melalui; <em>Facebook, Instagram, Website, Blanja.com, dan Qlapa.</em></p><p>Data dalam penelitian ini merupakan data kuantitatif dan kualitatif dengan menggunakan data campuran. Data diperoleh dari 5 Sanggar Batik Kayu Krebet yang mendapatkan hibah program kampung UKM digital. Metode analisis data yang digunakan peneliti dalam penelitian ini adalah menggunakan <em>uji paired sample t test</em> dan <em>uji wilxocon signed rank test</em>.</p><p>Hasil penelitian yang di dapat dengan menggunakan uji <em>paired sample t test</em> menunjukkan bahwa terdapat perbedaan yang signifikan antara omzet penjualan sebelum dan sesudah menggunakan fasilitas program kampung UKM digital dengan <em>uji paired sample t test, </em>adapun hasil uji taraf sig-2 tailed 0,36. Sedangkan hasil uji dengan <em>wilxocon signed rank test</em> mempunyai taraf nilai Z sebesar -2,023, dengan signifikansi 2- tailed sebesar 0,043. Artinya nilai signifikansi 0,043 &lt; 0,05, maka Hο ditolak atau ada perbedaan omzet penjualan sebelum dan sesudah menggunakan fasilitas program kampung UKM digital.</p><p> </p>