bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR‐143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2
Authors: Xu Bin , Wang Can , Wang Ya‐Li , Chen Shu‐Qiu , Wu Jian‐Ping , Zhu Wei‐Dong , Wang Chun‐Ying , Guan Han , Guan Chao , You Zong‐Hao , Chen Ming 
Published: March 2020

AbstractAlthough micro RNA (miRNA) expression profiles are widely investigated in renal cell carcinoma (RCC), their potential roles for affecting RCC initiation and progression remain largely unknown. Here, we examined the aberrant expression profiles of miRNAs inhuman metastatic RCC tissues based on Gene Expression Omnibus (GSE37989). We further validated them iRNAs expression data in the largest clinical dataset: The Cancer Genome Atlas (TCGA). And cell adhesion and migration abilities and epithelial me senchymal transition (EMT) related proteins were assessed in both normal and tumor RCC cell lines. We suggest that hsa‐miR‐143 is a potential tumor suppressor in RCC as its down regulation positively correlated with adverse prognosis. Biologically, cell adhesion, migration, and EMT were dramatically inhibited by miR‐143. Mechanistically, we found that miR‐143 targets ABL proto‐oncogene 2 (ABL2), which was also found to be an indicator for poor survival in TCGA database. Our results have important implications in understanding functions of miRNAs in metastatic RCC and will provide a basis for further clinical application.
Soil indicators of bird activity in the temperate climatic zone – A case‐study
Authors: Ligęza Sławomir , Pranagal Jacek , Smal Halina , Gmitrowicz‐Iwan Joanna 
Published: March 2020

AbstractThe importance of birds to pedogenesis and their impact on soil characteristics is a long‐standing topic of research. For this reason, the ornithogenic soils (avian soils) are distinguished as a separate category in some soil classifications. The continuous progress of knowledge on and changes in the management of the Earth's resources demand constant updating of definitions and classification criteria in various fields of environmental sciences. A search of the literature revealed few studies that examine the properties of bird soils in the temperate climate zone. This paper focuses on ornithogenic material: grit and bones deposited in the topsoil. Although areas covered by such soils are limited to 1–100 ha, they are found in high abundance in Europe and Asia. The surface horizon of the soil examined in the current study in Poznań, Poland, contained ample ornithogenic material; however, the soil's phosphorus content was remarkably low. Therefore, the analysed soil may not be considered as an ornithogenic soil, nor can it be attributed to the ornithic supplementary qualifier provided by the World Reference Base (WRB). The case study presented here exemplifies that soils containing ornithogenic material but lacking phosphorous compounds may occur in the temperate climate zone. Therefore, we conclude that ornithogenic material is the only permanent indicator of the existence of large groups of birds in non‐polar climate zones.
Chitosan/Alginate Dialdehyde Multilayer Films with Modulated pH‐Responsiveness and Swelling
Authors: Huang Junhao , Moghaddam Saeed Zajforoushan , Thormann Esben 
Published: March 2020

AbstractOxidation of alginate is a promising method that creates aldehyde groups, which can form stable cross‐links with amine groups on chitosan. In this work, it is shown that a systematic variation in the oxidation degree of alginate dialdehyde allows for effective tuning of the swelling capacity of chitosan/alginate dialdehyde multilayer films. Furthermore, it is demonstrated that the pH‐responsiveness of the multilayer films can be regulated by the choice of pH at which the layer‐by‐layer assembly is conducted. The combination of these two parameters allows for the designing polysaccharide multilayer films with a tunable degree of swelling and stimuli‐responsiveness.
A compact triple band circularly polarized planar antenna for wireless application
Authors: Kumari Kahani , Jaiswal Rahul K. , Srivastava Kumar V. 
Published: March 2020

AbstractA compact planar triple band circularly polarized (CP) antenna loaded with parasitic elements is proposed for wireless applications. For achieving circular polarization 2 inverted L‐shaped strips are added to the longer arm of dual band monopole and ground plane. A rectangular patch and a U shaped radiator are added to increase the impedance bandwidth as well as polarization purity. Electrical size of the antenna is 0.32λ × 0.32λ, where λ is the free space wavelength at its lowest CP frequency that is, 2.4 GHz. The structure shows an impedance bandwidths (│S11│ ≤ –10 dB) of 870 MHz (1.83‐2.7 GHz), 1.17 GHz (3.27‐4.44 GHz), and 400 MHz (4.75‐5.15 GHz). The 3‐dB axial ratio bandwidths of the proposed structure are 12.2%, 5.3%, and 4.28% at 2.375, 3.47, and 4.9 GHz of center frequencies respectively. The proposed structure is fabricated and its parameters are measured. Measured results nearly match with the simulated results and it shows satisfactory gain in all the three operating CP bands.
Surface plasmon resonance‐based fiber optic sensor prepared from bilayers of indium tin oxide‐indium oxide
Authors: Kapoor Vicky , Sharma Navneet K. 
Published: March 2020

AbstractExperimental investigations on fiber optic surface plasmon resonance (SPR) sensor with ITO (indium tin oxide)‐IO (indium oxide) layers are reported. Sensitivity ascends with increase in IO layer thickness till a definite thickness and begins descending with further enhancement in IO layer thickness. Maximum rise in sensitivity is observed for sensor fabricated from 40 nm ITO to 30 nm IO layers.
Heinz Gerrens Revisited: A New Look at the Impact of Reactor Type on Polymer Chain Morphology
Authors: Schork F. Joseph 
Published: March 2020

AbstractThe equations for predicting molecular weight distribution, copolymer composition distribution, and copolymer sequence distribution for three polymerization mechanisms (monomer linkage with termination, monomer linkage without termination, and polymer linkage), and three reactor types (batch/plug flow, homogenous continuous stirred tank, and segregated continuous stirred tank) are assembled from various sources and compared and contrasted.
An optimal‐multiphase homing methodology for powered parafoil systems
Authors: Sun Hao , Sun Qinglin , Chen Zengqiang , Tao Jin , Luo Shuzhen , Zeng Xianyi , Teng Haishan , Zhou Peng 
Published: March 2020

SummaryIn order to achieve the precise and agile homing control of the powered parafoil system, an optimal‐multiphase homing methodology is explored in this article. The proposed methodology is composed by a trajectory optimization method based on quantum genetic algorithm and a trajectory tracking method based on an improved active disturbance rejection control (ADRC). First, an improved optimization method combining the optimal and multiphase theory is proposed. The optimized trajectory consists of the simple trajectories, the standard lines and circles, while also satisfying the multiple constraints such as the wind disturbance, terrain avoidance, flared landing, and so on. Then, an improved active disturbance rejection controller is presented. For improving the agility of the system during the path switching and the disturbance rejection ability in windy environment, based on ADRC, a disturbance rejection control algorithm is designed for the horizontal controller of the system. By analyzing the aerodynamic characteristic of the system, the wind disturbance will be compensated previously with a feedforward compensation unit. It will be largely reduce the observation error of the extended state observer, while improving the control effect and the reaction speed. Finally, the hardware‐in‐the‐loop simulation is presented to prove the effectiveness of the proposed methodology. The results show that the optimization method can be achieved successfully and the optimized trajectory can be tracked by the improved ADRC controller precisely and agilely. The landing error is less than 15 m with the proposed homing methodology.
Sufficient optimality conditions for problems controlled by ordinary differential equations with behavior of blowup
Authors: Nowakowski Andrzej 
Published: March 2020

SummaryWe study the blowup problem for nonautonomous systems of ordinary differential equations. Sufficient optimality conditions for the controlled blowup time are derived, in terms of a dual dynamic programming methodology. We define an ε‐optimal value function and we construct sufficient ε‐optimality conditions for that function again in terms of a dual dynamic programming inequality.
Electrons and Hydroxyl Radicals Synergistically Boost the Catalytic Hydrogen Evolution from Ammonia Borane over Single Nickel Phosphides under Visible Light Irradiation
Authors: Song Jin , Gu Xiaojun , Zhang Hao 
Published: March 2020

AbstractFrom the perspective of tailoring the reaction pathways of photogenerated charge carriers and intermediates to remarkably enhance the solar‐to‐hydrogen energy conversion efficiency, we synthesized the three low‐cost semiconducting nickel phosphides Ni2P, Ni12P5 and Ni3P, which singly catalyzed the hydrogen evolution from ammonia borane (NH3BH3) in the alkaline aqueous solution under visible light irradiation at 298 K. The systematic investigations showed that all the catalysts had higher activities under visible light irradiation than in the dark and Ni2P had the highest photocatalytic activity with the initial turnover frequency (TOF) value of 82.7 min−1, which exceeded the values of reported metal phosphides at 298 K. The enhanced activities of nickel phosphides were attributed to the visible‐light‐driven synergistic effect of photogenerated electrons (e−) and hydroxyl radicals (.OH), which came from the oxidation of hydroxide anions by photogenerated holes. This was verified by the fluorescent spectra and the capture experiments of photogenerated electrons and holes as well as hydroxyl radicals in the catalytic hydrogen evolution process.
Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors
Authors: de Ruyck Jérôme , Dupont Christian , Lamy Elodie , Le Moigne Vincent , Biot Christophe , Guérardel Yann , Herrmann Jean‐Louis , Blaise Mickaël , Grassin‐Delyle Stanislas , Kremer Laurent , Dubar Faustine 
Published: March 2020

AbstractNon‐tuberculous mycobacterium (NTM) infections, such as those caused by Mycobacterium abscessus, are increasing globally. Due to their intrinsic drug resistance, M. abscessus pulmonary infections are often difficult to cure using standard chemotherapy. We previously demonstrated that a piperidinol derivative, named PIPD1, is an efficient molecule both against M. abscessus and Mycobacterium tuberculosis, the agent of tuberculosis, by targeting the mycolic acid transporter MmpL3. These results prompted us to design and synthesize a series of piperidinol derivatives and to determine the biological activity against M. abscessus. Structure‐activity relationship (SAR) studies pointed toward specific sites on the scaffold that can tolerate slight modifications. Overall, these results identified FMD‐88 as a new promising active analogue against M. abscessus. Also, we determined the pharmacokinetics properties of PIPD1 and showed that intraperitoneal administration of this compound resulted in promising serum concentration and an elimination half‐life of 3.2 hours.
Long‐term brain status and cognitive impairment in children treated for high‐risk acute lymphoblastic leukemia with and without allogeneic hematopoietic stem cell transplantation: A single‐center study
Authors: Zając‐Spychała Olga , Pawlak Mikolaj A. , Karmelita‐Katulska Katarzyna , Pilarczyk Jakub , Jończyk‐Potoczna Katarzyna , Przepióra Agnieszka , Derwich Katarzyna , Pieczonka Anna , Wachowiak Jacek 
Published: March 2020

AbstractAimThe aim of the study was to assess long‐term consequences of central nervous system (CNS) prophylaxis in patients with high‐risk ALL (HR‐ALL) treated according to ALL IC‐BFM 2002 and to compare observed abnormalities in patients who underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT) with those who received only prophylactic CNS irradiation (12 Gy) and with control group.Patients and methodsWe studied 29 patients with HR‐ALL in CR1 after treatment according to protocol ALL IC‐BFM 2002 (14 with allo‐HSCT conditioned with fractionated total body irradiation [FTBI] and 15 without HSCT) and 16 children with newly diagnosed ALL (control group). The median time from therapy completion to evaluation was 5 years. To assess brain status, volumetric T1‐weighted sequences of magnetic resonance imaging were used. Neuropsychological assessment based on battery neuropsychological tests.ResultsTransplanted patients had significantly lower volumes of white and gray matter (P = .048 and P < .001) and also of subcortical structures, including the thalamus (P < .001), the hippocampus (P = .007), the putamen (P = .011), the globus pallidus (P = .001), and the accumbens (P < .001). In addition, these patients had generally lower cognitive performance, especially in vocabulary (P = .011), visuospatial ability (P = .047), executive functions and attention (P = .034; P = .002; P = .048), and processing speed (P = .049 and P = .037). The thalamus volume is correlated with neuropsychological performance in verbal functions (P < .001), executive functions (P < .001 and P = .024), and processing speed (P < .001).ConclusionsIn pediatric patients treated for ALL, FTBI‐based preparative regimen preceding allo‐HSCT causes reduction of subcortical structure volumes and decline in cognitive performance. The observed long‐term structural and functional CNS sequelae are significantly more pronounced in transplanted HR‐ALL patients than in those treated with prophylactic CNS‐ radiotherapy only.
Impact of vascular anomalies on the PTEN phenotype in children and young adults
Authors: Gurunathan Arun , Ricci Kiersten , Iacobas Ionela , Rednam Surya P. , Wusik Katie , Fei Lin , Hammilll Adrienne M. 
Published: March 2020

AbstractGermline PTEN (phosphatase and tensin homolog) mutations lead to inappropriate cell survival and growth, and a predisposition to multiple cancers. Some patients also have vascular anomalies (VAs), and it is unclear whether these patients have different phenotypes or oncologic risks. We conducted a two‐institution retrospective cohort study to better understand the phenotypes of children and young adults with PTEN mutations, and to compare individuals with VA to those without. Almost half of the patients had thyroid tumors and nearly one quarter developed gastrointestinal tumors before 30 years of age. The presence of VA was positively associated with bulky overgrowth but did not appear to modify oncologic risk.
Pre‐pregnancy obesity and childhood malignancies: A population‐based cohort study
Authors: Kessous Roy , Wainstock Tamar , Sheiner Eyal 
Published: March 2020

AbstractObjectiveExploring the effect of maternal obesity during pregnancy on the long‐term health of offspring is of great importance. The aim of this study was to evaluate the association between maternal pre‐pregnancy obesity and future risk of childhood malignancies.Study designA population‐based cohort analysis comparing the risk for long‐term childhood malignancies (up to the age of 18 years) in children born (1991‐2014) to mothers with and without pre‐pregnancy obesity (body mass index > 30) was conducted in July 2017. Childhood malignancies were predefined based on ICD‐9 codes, as recorded in the hospital medical files. Children with congenital malformations and multiple gestations were excluded from the analysis. The Kaplan‐Meier survival curve was constructed to compare cumulative oncological morbidity in both groups over time. The Cox proportional hazards model was used to control for confounders.ResultsDuring the study period, 241 273 infants met the inclusion criteria; 3268 were born to mothers with pre‐pregnancy obesity. Children of obese women had significantly increased risk for several childhood malignancies (including brain tumors) as well as increased risk for total hospitalizations with malignancy diagnoses, even after controlling for several confounders (adjusted HR 1.90, 95% CI 1.07‐3.37, P = 0.028). Cumulative incidence of oncological morbidity was also significantly increased over time in the studied group (log‐rank P = 0.023).ConclusionMaternal pre‐pregnancy obesity is significantly associated with an increased long‐term risk for general childhood malignancies, and specifically brain tumors in the offspring. These results are important when counseling mothers regarding potential future risks and recommended lifestyle modifications.
Registration of GP‐VT NC 01 peanut germplasm
Authors: Balota M. , Isleib T. G. 
Published: March 2020

AbstractGP‐VT NC 01 (Reg. no. GP‐238, PI 691613) is a virginia‐type peanut (Arachis hypogaeaL. subsp.hypogaeavar.hypogaea) with good agronomic characteristics and improved drought tolerance. GP‐VT NC 01 was tested under the experimental designation N05006. Replicated yield tests started in the F6generation in North Carolina in 2005. From 2008 through 2010, GP‐VT NC 01 was tested in replicated trials in the Peanut Variety and Quality Evaluation, multistate project S1038, in Virginia, North Carolina, and South Carolina. In 2013 and 2014, GP‐VT NC 01 was tested in the field at the Tidewater Agricultural Research and Experiment Station in Suffolk, VA, under rain exclusion shelters with controlled water regimes ranging from optimum soil moisture to severe drought. In these tests, GP‐VT NC 01 was compared with the current cultivars grown in Virginia and the Carolinas—‘Bailey’, ‘Sugg’, ‘Sullivan’, and ‘Wynne’—and a drought‐tolerant species derived germplasm line (GP‐NC WS17). Under “normal” weather, in rainfed production, GP‐VT NC 01 had similar yield to Bailey and Sugg and significantly better yield than Sullivan or Wynne. Extra‐large kernels content was least, although not significantly smaller than Sullivan and Wynne. No significant differences in sound mature kernels were noted among the cultivars tested. However, during dry and hot years, and under drought‐controlled conditions, the yield of GP‐VT NC 01 was significantly higher than that of the other cultivars tested. Thus, the release of GP‐VT NC 01 provides producers with a profitable option that will perform well under drought stress.
Developing a Robust Assay to Monitor and Quantify Key Players of Metabolic Pathways during Adipogenesis by Targeted Proteomics
Authors: Hentschel Andreas , Ahrends Robert 
Published: March 2020

AbstractTargeted data acquisition using nano liquid chromatrography (nano‐LC) coupled mass spectrometry is an emerging approach when there is a need to quantify proteins with high accuracy, sensitivity, and reproducibility. Nevertheless, creating assays meeting all those criteria still remains a laborious task, especially when investigating low abundant proteins and small concentration changes. In this work a targeted data acquisition workflow is developed reducing time and effort to target and investigate key players of metabolic pathways during the process of adipocyte differentiation. This leads to accurate and sensitive quantification of proteins involved in the synthesis of fatty acids, glycerolipids, glycerophospholipids, sphingolipids, the production of energy and reduction equivalents. Additionally low abundant signaling molecules part of the peroxisome proliferator‐activated receptor gamma (PPARγ) and insulin signaling pathway with ≈400 for the insulin receptor substrate and 1100 copies per cell for PPARγ are determined.
Robustness of visible near‐infrared and mid‐infrared spectroscopic models to changes in the quantity and quality of crop residues in soil
Authors: Greenberg Isabel , Linsler Deborah , Vohland Michael , Ludwig Bernard 
Published: March 2020

AbstractThe robustness of soil organic carbon (SOC) and total nitrogen (TN) content prediction accuracy by visible near‐infrared spectroscopy (visNIRS) and mid‐infrared spectroscopy (MIRS) models after a change in the quantity or quality of crop residues requires investigation. Arable soils (0–20 cm) from 20 locations across Germany were collected, and 0, 2, 4, or 8 g C kg soil−1 of wheat straw (C/N ratio, 54) or clover (C/N ratio, 13) were added. Before and after a 56‐d incubation, dried and ground samples were measured for SOC and TN content and by visNIRS and MIRS. The complete dataset (n = 280) was subdivided into calibration and validation datasets to test the robustness of partial least squares regression models to changes in crop residue quantity and quality in soil. Noise‐reducing data pretreatments included region selection, moving averages, resampling every second data point, and the Savitzky‐Golay algorithm. The MIRS estimates for SOC (7.4–33 g kg−1) had lower root mean squared error of validation (RMSEV = 0.9–2.9 g kg−1) compared with visNIRS (RMSEV = 1.6–7.1 g kg−1). Total N estimates (0.7–2.8 g kg−1) were more comparable for MIRS (RMSEV = 0.1–0.3 g kg−1) and visNIRS (RMSEV = 0.1–1.0 g kg−1). Loadings of partial least squares regression components suggested the predictive mechanisms for SOC and TN were more similar for visNIRS than for MIRS. Differing crop residue quantity or quality in calibration versus validation resulted in biased SOC and TN estimates by visNIRS and MIRS models. However, calibration with a global residue model containing all soils and crop residue quantities and qualities lowered RMSEV for SOC and TN prediction with visNIRS and MIRS, demonstrating the usefulness of this approach.
Safety and pharmacokinetics of the orally available antiprionic compound PRI‐002: A single and multiple ascending dose phase I study
Authors: Kutzsche Janine , Jürgens Dagmar , Willuweit Antje , Adermann Knut , Fuchs Carola , Simons Stefanie , Windisch Manfred , Hümpel Michael , Rossberg Wolfgang , Wolzt Michael , Willbold Dieter 
Published: March 2020

AbstractIntroductionPRI‐002 is an orally available anti–amyloid beta (Aβ) prionic compound developed for direct disassembly of toxic Aβ oligomers relevant to Alzheimer's disease.MethodsTwo placebo‐controlled clinical phase I trials with oral dosing of PRI‐002 were conducted in healthy young subjects: A single ascending dose trial (4, 12, 36, 108, or 320 mg PRI‐002 or placebo) in 40 participants followed by a multiple ascending dose study with daily 160 mg PRI‐002 for 14 days or 320 mg for 28 days in 24 participants. The main objectives were safety, tolerability, and evaluation of pharmacokinetic (PK) parameters.ResultsPRI‐002 was safe and well tolerated after single and multiple oral administration up to the highest doses. PRI‐002 was absorbed rapidly and drug exposure increased proportional to dose. During repeated daily administration, the drug accumulated by a factor of about three. Steady‐state conditions were reached after 1 to 2 weeks.ConclusionsThe safety and PK results encourage further clinical development of PRI‐002.