bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of an Electronic Surveillance Algorithm to Identify Patients With Post-Operative Surgical Site Infections Using National Surgical Quality Improvement Program Pediatric Data
Authors: Berrondo Claudia , Bettinger Brendan , Katz Cindy B , Bauer Jennifer , Shnorhavorian Margarett , Zerr Danielle M 
Published: December 2019

Abstract

Background
Surgical site infections (SSIs) are common, but data related to these infections maybe difficult to capture. We developed an electronic surveillance algorithm to identify patients with SSIs. Our objective was to validate our algorithm by comparing it with our institutional National Surgical Quality Improvement Program Pediatric (NSQIP Peds) data.

Methods
We applied our algorithm to our institutional NSQIP Peds 2015–2017 cohort. The algorithm consisted of the presence of a diagnosis code for post-operative infection or the presence of 4 criteria: diagnosis code for infection, antibiotic administration, positive culture, and readmission/surgery related to infection. We compared the algorithm’s SSI rate to the NSQIP Peds identified SSI. Algorithm performance was assessed using sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and Cohen’s kappa. The charts of discordant patients were reviewed to understand limitations of the algorithm.

Results
Of 3879 patients included, 2.5% had SSIs by NSQIP Peds definition and 1.9% had SSIs by our algorithm. Our algorithm achieved a sensitivity of 44%, specificity of 99%, NPV of 99%, PPV of 59%, and Cohen’s kappa of 0.5. Of the 54 false negatives, 37% were diagnosed/treated as outpatients, 31% had tracheitis, and 17% developed SSIs during their post-operative admission. Of the 30 false positives, 33% had an infection at index surgery and 33% had SSIs related to other surgeries/procedures.

Conclusions
Our algorithm achieved high specificity and NPV compared with NSQIP Peds reported SSIs and may be useful when identifying SSIs in patient populations that are not actively monitored for SSIs.
Gastric schwannoma: a diagnosis that should be known in 2019
Authors: Lomdo Massama , Setti Khadija , Oukabli Mohamed , Moujahid Mountassir , Bounaim Ahmed 
Published: December 2019

Abstract
Gastric schwannoma (GS) is a rare neoplasm of the stomach deriving from Schwann cells of the peripheral nerves in the stomach. It accounts for 0.2% of all gastric tumors and is mostly benign, slow-growing and asymptomatic. Due to its rarity, GS is not widely recognized by clinicians. Preoperatively, GSs are difficult to differentiate from other mesenchymal tumors, such as gastrointestinal stromal tumor (GIST) or leiomyoma, which develop from mesenchymal stem cells. The optimal management of GS is based on the symptoms of the patient, tumor size and histologic grading. Here, we report the case of a GS in a 73-year-old female who underwent a wedge gastric resection following a clinical diagnosis of GIST. A histological and immunohistochemical study was performed excluding the misdiagnosis of GIST. The histomorphological features of the lesion and absence of c-Kit and strong positivity of S100 indicated the diagnosis of GS.
MYB57 transcriptionally regulates MAPK11 to interact with PAL2;3 and modulate rice allelopathy
Authors: Fang Changxun , Yang Luke , Chen Weisi , Li Lanlan , Zhang Pengli , Li Yingzhe , He Haibin , Lin Wenxiong 
Published: December 2019

AbstractRice allelopathy is a natural method of weed control that is regarded as an eco-friendly practice in agroecology. The allelopathic potential of rice is regulated by various genes, including those that encode transcription factors. Our study characterized a MYB transcription factor, OsMYB57, to explore its role in the regulation of rice allelopathy. Increasing the expression of OsMYB57 in rice using the transcription activator VP64 resulted in increased inhibitory ratios against barnyardgrass. The gene expression levels of OsPAL, OsC4H, OsOMT, and OsCAD from the phenylpropanoid pathway were also up-regulated, and the content of l-phenylalanine increased. Chromatin immunoprecipitation incorporated with HiSeq demonstrated that OsMYB57 transcriptionally regulated a mitogen-activated protein kinase (OsMAPK11); in addition, OsMAPK11 interacted with OsPAL2;3. The expression of OsPAL2;3was higher in the allelopathic rice PI312777 than in the non-allelopathic rice Lemont, and OsPAL2;3 was negatively regulated by Whirly transcription factors. Moreover, microbes with weed-suppression potential, including Penicillium spp. and Bacillus spp., were assembled in the rhizosphere of the rice accession Kitaake with increased expression of OsMYB57, and were responsible for phenolic acid induction. Our findings suggest that OsMYB57 positively regulates rice allelopathy, providing an option for the improvement of rice allelopathic traits through genetic modification.
Empty Bullet-Related Ocular Injuries During Military Shooting Training: A 20-Year Review
Authors: Guven Soner , Durukan Ali Hakan 
Published: December 2019

Abstract

Introduction
Empty bullet-related ocular injuries (EBOI) are rare and may result in unfavorable visual outcomes due to both open globe and closed globe injuries. To our knowledge, no reports of such injuries in terms of outcomes have been previously described in the literature. The aim of this study was to describe the treatment performed and ocular outcomes of such injuries.

Materials and Methods
EBOI of 23 cases were reviewed who were referred to Gulhane School of Medicine Department of Ophthalmology between January 1998 and January 2018. Patient demographics, ocular signs (initial and final), injury types, type and number of interventions, and ocular trauma scores were recorded.

Results
In total, 23 eyes of the 23 patients with an average age of 22.3 ± 4.54 years (range, 20–41 years) were included in the study. All of the patients were male, and all injuries were due to empty bullets during shooting training. None had ocular protection at the time of ocular injury. Fourteen patients (60.9%) were open globe injuries, whereas nine (39.1%) of them were closed globe injuries. Mean ocular trauma scores category of the cases was 2.52 ± 1.03. The baseline and final visual acuity was 20/200 or better in 21.7% and 69.5% of eyes, respectively. Nineteen eyes (82.7%) had undergone a total of 31 surgeries with a 1.34 ± 0.88 surgery average.

Conclusions
The prognosis of EBOI is unpredictable and is dependent on the severity of ocular damage. The best treatment option is prevention of EBOI with protective eyewear.
Interplasmoid Compton scattering and the Compton dominance of BL Lacs
Authors: Christie I M , Petropoulou M , Sironi L , Giannios D 
Published: December 2019

ABSTRACT
Blazar emission models based on magnetic reconnection succeed in reproducing many observed spectral and temporal features, including the short-duration luminous flaring events. Plasmoids, a self-consistent by-product of the tearing instability in the reconnection layer, can be the main source of blazar emission. Kinetic simulations of relativistic reconnection have demonstrated that plasmoids are characterized by rough energy equipartition between their radiating particles and magnetic fields. This is the main reason behind the apparent shortcoming of plasmoid-dominated emission models to explain the observed Compton ratios of BL Lac objects. Here, we demonstrate that the radiative interactions among plasmoids, which have been neglected so far, can assist in alleviating this contradiction. We show that photons emitted by large, slow-moving plasmoids can be a potentially important source of soft photons to be then upscattered, via inverse Compton, by small fast-moving, neighbouring plasmoids. This interplasmoid Compton scattering process can naturally occur throughout the reconnection layer, imprinting itself as an increase in the observed Compton ratios from those short and luminous plasmoid-powered flares within BL Lac sources, while maintaining energy equipartition between radiating particles and magnetic fields.
The case against gravitational millilensing in the multiply-imaged quasar B1152+199
Authors: Asadi Saghar , Zackrisson Erik , Varenius Eskil , Freeland Emily , Conway John , Wiik Kaj 
Published: December 2019

ABSTRACT
Previous very long baseline interferometry (VLBI) observations of the quasar B1152+199 at 5 GHz has revealed two images of a strongly lensed jet with seemingly discordant morphologies. Whereas the jet appears straight in one of the images, the other exhibits slight curvature on milliarcsecond scales. This is unexpected from the lensing solution and has been interpreted as possible evidence for secondary, small-scale lensing (millilensing) by a compact object with a mass of 105–107 M⊙ located close to the curved image. The probability for such a superposition is extremely low unless the millilens population has very high surface number density. Here, we revisit the case for millilensing in B1152+199 by combining new global–VLBI data at 8.4 GHz with two data sets from the European VLBI Network (EVN) at 5 GHz (archival), and the previously published 5 GHz Very Long Baseline Array (VLBA) data. We find that the new data with a more circular synthesized beam, exhibits no apparent milliarcsecond-scale curvature in image B. Various observations of the object spanning ∼15 yr apart enable us to improve the constraints on lens system to the point that the only plausible explanation left for the apparent curvature is the artefact due to the shape of the synthesized beam.
Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors
Authors: Marcovich Irina , Moglie Marcelo J , Carpaneto Freixas Agustín E , Trigila Anabella P , Franchini Lucia F , Plazas Paola V , Lipovsek Marcela , Elgoyhen Ana Belén 
Published: December 2019

AbstractThe expansion and pruning of ion channel families has played a crucial role in the evolution of nervous systems. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels with distinct roles in synaptic transmission at the neuromuscular junction, the central and peripheral nervous system, and the inner ear. Remarkably, the complement of nAChR subunits has been highly conserved along vertebrate phylogeny. To ask whether the different subtypes of receptors underwent different evolutionary trajectories, we performed a comprehensive analysis of vertebrate nAChRs coding sequences, mouse single-cell expression patterns, and comparative functional properties of receptors from three representative tetrapod species. We found significant differences between hair cell and neuronal receptors that were most likely shaped by the differences in coexpression patterns and coassembly rules of component subunits. Thus, neuronal nAChRs showed high degree of coding sequence conservation, coupled to greater coexpression variance and conservation of functional properties across tetrapod clades. In contrast, hair cell α9α10 nAChRs exhibited greater sequence divergence, narrow coexpression pattern, and great variability of functional properties across species. These results point to differential substrates for random change within the family of gene paralogs that relate to the segregated roles of nAChRs in synaptic transmission.
Sexual Selection Shapes Seminal Vesicle Secretion Gene Expression in House Mice
Authors: Simmons Leigh W , Sloan Nadia S , Firman Renée C 
Published: December 2019

AbstractReproductive proteins typically have high rates of molecular evolution, and are assumed to be under positive selection from sperm competition and cryptic female choice. However, ascribing evolutionary divergence in the genome to these processes of sexual selection from patterns of association alone is problematic. Here, we use an experimental manipulation of postmating sexual selection acting on populations of house mice and explore its consequences for the expression of seminal vesicle secreted (SVS) proteins. Following 25 generations of selection, males from populations subjected to postmating sexual selection had evolved increased expression of at least two SVS genes that exhibit the signature of positive selection at the molecular level, SVS1 and SVS2. These proteins contribute to mating plug formation and sperm survival in the female reproductive tract. Our data thereby support the view that sexual selection is responsible for the evolution of these seminal fluid proteins.
Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans
Authors: Reed Kailee J , Svendsen Joshua M , Brown Kristen C , Montgomery Brooke E , Marks Taylor N , Vijayasarathy Tarah , Parker Dylan M , Nishimura Erin Osborne , Updike Dustin L , Montgomery Taiowa A 
Published: December 2019

Abstract
Piwi-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) are distinct classes of small RNAs required for proper germline development. To identify the roles of piRNAs and siRNAs in regulating gene expression in Caenorhabditis elegans, we subjected small RNAs and mRNAs from the gonads of piRNA and siRNA defective mutants to high-throughput sequencing. We show that piRNAs and an abundant class of siRNAs known as WAGO-class 22G-RNAs are required for proper expression of spermatogenic and oogenic genes. WAGO-class 22G-RNAs are also broadly required for transposon silencing, whereas piRNAs are largely dispensable. piRNAs, however, have a critical role in controlling histone gene expression. In the absence of piRNAs, histone mRNAs are misrouted into the nuclear RNAi pathway involving the Argonaute HRDE-1, concurrent with a reduction in the expression of many histone mRNAs. We also show that high-level gene expression in the germline is correlated with high level 22G-RNA production. However, most highly expressed genes produce 22G-RNAs through a distinct pathway that presumably involves the Argonaute CSR-1. In contrast, genes targeted by the WAGO branch of the 22G-RNA pathway are typically poorly expressed and respond unpredictably to loss of 22G-RNAs. Our results point to broad roles for piRNAs and siRNAs in controlling gene expression in the C. elegans germline.
Interventions to Increase Completion of Hepatitis B Vaccination in People who Inject Drugs: A Systematic Review and Meta-analysis
Authors: Tressler Stacy , Bhandari Ruchi 
Published: December 2019

AbstractIncreases in opioid misuse and injection drug use have resulted in a rise in acute cases of hepatitis B. We conducted a systematic review and meta-analysis of randomized studies to determine the effect (pooled odds ratio) of interventions to increase hepatitis B vaccination completion in people who inject drugs (PWID). Odds ratios from the included studies were combined to create a pooled odds ratio (OR) using the Inverse Heterogeneity Model. Eleven studies met the eligibility criterion of having a randomized intervention to increase hepatitis B virus vaccination completion among PWID. The odds of vaccine completion in the intervention group were greater than in the control/comparison group (pooled OR, 2.53; 95% confidence interval [CI], 1.07–5.99). Subgroup analysis indicated that financial incentives were most effective (OR, 7.01; 95% CI, 2.88–17.06), followed by accelerated vaccine schedules (OR, 1.90; 95% CI, 1.14–3.14). Interventions using financial incentives and accelerated vaccine schedules are moderately effective at increasing hepatitis B vaccination completion in PWID.
The influence of Megasphaera elsdenii on rumen morphometrics of cull cows immediately stepped up to a high-energy finishing diet
Authors: DeClerck Jonathan C , Reeves Nathan R , Miller Mark F , Johnson Bradley J , Ducharme Gary A , Rathmann Ryan J 
Published: December 2019

AbstractForty-five beef cull cows [body weight (BW) = 503 ± 58 kg; body condition score (BCS) = 2.1 ± 0.6] were randomized into two treatments to compare the effects of oral drenching of no probiotic vs. 100 mL of Megasphaera elsdenii NCIMB 41125 (M. elsdenii culture; Lactipro Advance; 2 × 108 cfu/mL; MS Biotec, Inc., Wamego, KS) on the realimentation of cull cows. The study featured a rapid 0-d step-up of concentrate-naïve cull cows to a 90% concentrate diet (1.43 Mcal/kg of NEg). The cows were finished for 35 d and were fitted with a wireless rumination tag (Allflex Flex Tag; SCR Engineers, Ltd, Netanya, Israel), which tracked head movement to record eating and chewing activity. Rumen morphometrics was recorded on the harvest floor, with each carcass assigned a rumenitis score, and a fragment of the cranial sac removed for further papillae analysis. An additional 23, thin, non-fed cull cows were harvested at the same abattoir to compare the effects of concentrate realimentation on ruminal morphometrics. Megasphaera elsdenii culture-drenched cattle registered a 13.3% increase in rumination time (39.27 min/d, P = 0.03) during the first week of the trial compared to controls. A numerical rumination advantage for M. elsdenii culture-administered cattle was observed during week 2 of trial (P = 0.17), with no differences between treatments from weeks 3 to 5 (P ≥ 0.40). Subjective rumenitis evaluations approached a tendency (P = 0.12), with non-M. elsdenii culture-drenched concentrate-fed cattle logging twice the score of their day 0 cohorts (2.52 vs. 1.17) suggesting considerable lactic insults occurred to the ruminal epithelium in the short 35-d trial. Despite the short feeding duration, concentrate realimentation prompted a significant improvement in mean papillae area (P &lt; 0.01). Among concentrate-fed treatments, M. elsdenii culture-drenched cattle posted superior absorptive surface area (P = 0.01) and a greater ratio of papillae area of absorptive surface area (P = 0.05), suggesting that M. elsdenii culture is favorably altering the ecology of the rumen and promoting papillae growth perhaps by mitigating lactate-driven pH drops. In conclusion, M. elsdenii culture application in a 0-d step-up protocol to finishing diets can help mitigate the effects of ruminal acidosis.
Expectant Management of Hypertensive Disorders of Pregnancy and Future Cardiovascular Morbidity
Authors: Rosenbloom Joshua I. , Lewkowitz Adam K. , Lindley Kathryn J. , Nelson D. Michael , Macones George A. , Cahill Alison G. , Olsen Margaret A. , Stout Molly J. 
Published: December 2019

OBJECTIVE:
To test the hypothesis that a longer length of time between diagnosis of hypertensive disorders of pregnancy and delivery is associated with increased risk of cardiovascular morbidity in the years after delivery.

METHODS:
This is a retrospective cohort study based in the New York State Inpatient Database. The first delivery for all patients from 2005 to 2014 who delivered preterm with an International Classification of Diseases, 9th Revision, Clinical Modification code for hypertensive disorders of pregnancy (excluding isolated chronic hypertension) was included. The duration between diagnosis and delivery was divided into 7 days or less or more than 7 days. The primary outcome was admission for a composite of cardiovascular disease, stroke, or death after the index delivery through December 31, 2014.

RESULTS:
There were 22,594 patients with a median follow-up period of 5.2 years: 19,750 (87.4%) were delivered within 7 days of diagnosis and 2,844 (12.6%) were delivered more than 7 days from diagnosis. The primary outcome occurred in 216 (1.1%) patients in the 0–7 days group (21 events/10,000 person-years) and 67 (2.4%) patients in the more than 7 days group (46 events/10,000 person-years), adjusted hazard ratio 1.45 (95% CI 1.09 to 1.93). The findings were robust in a number of sensitivity analyses.

CONCLUSIONS:
Prolonged expectant management of preterm hypertensive disorders of pregnancy is associated with an increased risk of maternal cardiac disease in the ensuing years.
Interpersonal Trauma as a Marker of Risk for Urinary Tract Dysfunction in Midlife and Older Women
Authors: Boyd Brittni A. J. , Gibson Carolyn J. , Van Den Eeden Stephen K. , McCaw Brigid , Subak Leslee L. , Thom David , Huang Alison J. 
Published: December 2019

OBJECTIVE:
To examine relationships between interpersonal trauma exposures and urinary symptoms in community-dwelling midlife and older women.

METHODS:
We analyzed cross-sectional data from a multiethnic cohort of women aged 40–80 years enrolled in an integrated health care system in California. Lifetime history of intimate partner violence (IPV) and sexual assault, current posttraumatic stress disorder (PTSD) symptoms, and current urinary symptoms were assessed using structured-item questionnaires. Multivariable-adjusted logistic regression models examined associations between traumatic exposures and PTSD symptoms with any weekly urinary incontinence, stress-type incontinence, urgency-type incontinence, and nocturia two or more times per night.

RESULTS:
Of the 1,999 participants analyzed, 21.7% women reported lifetime emotional IPV, 16.2% physical IPV, 19.7% sexual assault, and 22.6% reported clinically significant PTSD symptoms. Overall, 45% reported any weekly incontinence, 23% stress-type incontinence, 23% urgency-type incontinence, and 35% nocturia. Exposure to emotional IPV was associated with any weekly incontinence (odds ratio [OR] 1.33, 95% CI 1.04–1.70), stress-type incontinence (OR 1.30, 95% CI 1.00–1.65), urgency-type incontinence (OR 1.30, 95% CI 1.00–1.70), and nocturia (OR 1.73, 95% CI 1.36–2.19). Physical IPV exposure was associated with nocturia (OR 1.35, 95% CI 1.04–1.77), but not incontinence. Sexual assault history was not associated with weekly incontinence of any type or nocturia. Symptoms of PTSD were associated with all urinary symptoms assessed, including any weekly incontinence (OR 1.46, 95% CI 1.15–1.85), stress-type incontinence (OR 1.70, 95% CI 1.32–2.20), urgency-type incontinence (OR 1.60, 95% CI 1.24–2.06), and nocturia (OR 1.95, 95% CI 1.55–2.45).

CONCLUSION:
More than 20% of women in this multiethnic, community-based cohort reported a history of IPV, PTSD symptoms, or both, which were associated with symptomatic urinary tract dysfunction. Findings highlight the need to provide trauma-informed care of midlife and older women presenting with urinary symptoms.