bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical predictive factors for diagnosis of MOG-IgG and AQP4-IgG related paediatric optic neuritis: a Chinese cohort study
Authors: Yang Mo , Wu Yiqun , Lai Mengying , Song Honglu , Li Hongen , Sun Mingming , Xie Lindan , Zhou Huanfen , Xu Quangang , Wei Shihui , Wu Weiping 
Published: November 2020

BackgroundDifferent glial-autoantibodies-related paediatric optic neuritis (ON) are associated with different clinical characteristics and prognosis that require different treatments. Because glial autoantibody detection is not available in some parts of the world and there is often a delay in obtaining results, clinical factors that can be used to predict the subtype of paediatric ON are needed.MethodsThis was a single-centre retrospective cohort study. Children who presented with their first ON attack and with complete clinical data were included in the analysis. Single and multiple parameters for predicting paediatric myelin oligodendrocyte glycoprotein immunoglobin-associated ON (MOG-ON) and aquaporin-4 immunoglobin-related ON (AQP4-ON) were calculated.Results78 paediatric patients had their first ON attack from January 2016 to December 2019, of whom 69 were included in the final analysis, including 33 MOG-ON cases, 17 AQP4-ON cases and 19 Seronegative-ON cases. For predicting paediatric MOG-ON, the most sensitive predictors were ‘male or optic disc swelling (ODS) or bilateral’ (sensitivity 0.97 (95% CI 0.82 to 1.00)) and ‘follow-up visual acuity (VA) ≤0.1 logMAR or ODS’ (sensitivity 0.97 (95% CI 0.82 to 1.00)), and the most specific factor was ‘Age ≤11 y and simultaneous CNS involvement’ (specificity 0.97 (95% CI 0.84 to 1.00)). For predicting paediatric AQP4-ON, the most sensitive predictor was ‘Female or without ODS’ (sensitivity 1.00 (95% CI 0.77 to 1.00)), and the most specific factors were Neurological history (sensitivity 0.94 (95% CI 0.83 to 0.98)) and follow-up VA >1.0 logMAR (sensitivity 0.96 (95% CI 0.86 to 0.99)).ConclusionAccording to our data from a Chinese paediatric cohort, using multiple parameters increases the sensitivity and specificity of diagnosing paediatric MOG-ON and AQP4-ON. These can assist clinicians in diagnosing and treating paediatric ON when glial autoantibody status is not available.
Randomised sham-controlled double-blind trial evaluating remote ischaemic preconditioning in solid organ transplantation: a study protocol for the RIPTRANS trial
Authors: Uutela Aki , Helanterä Ilkka , Lemström Karl , Passov Arie , Syrjälä Simo , Åberg Fredrik , Mäkisalo Heikki , Nordin Arno , Lempinen Marko , Sallinen Ville 
Published: November 2020

IntroductionRemote ischaemic preconditioning (RIPC) using a non-invasive pneumatic tourniquet is a potential method for reducing ischaemia-reperfusion injury. RIPC has been extensively studied in animal models and cardiac surgery, but scarcely in solid organ transplantation. RIPC could be an inexpensive and simple method to improve function of transplanted organs. Accordingly, we aim to study whether RIPC performed in brain-dead organ donors improves function and longevity of transplanted organs.Methods and analysesRIPTRANS is a multicentre, sham-controlled, parallel group, randomised superiority trial comparing RIPC intervention versus sham-intervention in brain-dead organ donors scheduled to donate at least one kidney. Recipients of the organs (kidney, liver, pancreas, heart, lungs) from a randomised donor will be included provided that they give written informed consent. The RIPC intervention is performed by inflating a thigh tourniquet to 300 mm Hg 4 times for 5 min. The intervention is done two times: first right after the declaration of brain death and second immediately before transferring the donor to the operating theatre. The sham group receives the tourniquet, but it is not inflated. The primary endpoint is delayed graft function (DGF) in kidney allografts. Secondary endpoints include short-term functional outcomes of transplanted organs, rejections and graft survival in various time points up to 20 years. We aim to show that RIPC reduces the incidence of DGF from 25% to 15%. According to this, the sample size is set to 500 kidney transplant recipients.Ethics and disseminationThis study has been approved by Helsinki University Hospital Ethics Committee and Helsinki University Hospital’s Institutional Review Board. The study protocol was be presented at the European Society of Organ Transplantation congress in Copenhagen 14−15 September 2019. The study results will be submitted to an international peer-reviewed scientific journal for publication.Trial registration numberNCT03855722.
Use of heated tobacco products in smoke-free locations in Japan: the JASTIS 2019 study
Authors: Kiyohara Kosuke , Tabuchi Takahiro 
Published: November 2020

ObjectiveWe aimed to examine the use of heated tobacco products (HTPs) in locations where cigarette smoking was not allowed, and to explore the factors associated with such use among Japanese HTP users.MethodsAn internet-based self-reported questionnaire survey was conducted in 2019 as part of the Japan Society and New Tobacco Internet Survey. The study subjects were respondents who self-reported having used HTPs in the last year. The proportions of those who had ever used or frequently used HTPs in locations where tobacco smoking was not allowed in the last year were calculated. These locations included home, restaurants and workplaces. Furthermore, potential factors associated with HTP use in such smoke-free locations were examined using multivariable logistic regression analyses.ResultsThe proportion of HTP users who had ever used HTPs in smoke-free locations in the last year was 20.7% (148/716) at home, 11.8% (128/1081) in restaurants and 11.9% (113/950) in workplaces. The proportion of those who had frequently used HTPs in those locations was 9.5% (68/716) at home, 4.8% (52/1081) in restaurants and 8.0% (76/950) in workplaces. The statistically significant factors associated with HTP use varied by location. Generally, respondents who thought HTP use was not forbidden in places where tobacco smoking is forbidden were likely to use HTPs in such locations.ConclusionIn Japan, a considerable number of people used HTPs in locations where tobacco smoking was not allowed. Policymakers should establish clear rules about use of HTPs in smoke-free environments.
Profitability of continuous-cover forestry in Norway spruce dominated peatland forest and the role of water table
Authors: Juutinen Artti , Shanin Vladimir , Ahtikoski Anssi , Rämö Janne , Mäkipää Raisa , Laiho Raija , Sarkkola Sakari , Laurén Ari , Penttilä Timo , Hökkä Hannu , Saarinen Markku 
Published: November 2020

Continuous-cover forestry (CCF) is expected to reduce the negative environmental impacts of peatland forestry in comparison with rotation forestry (RF), but the unknown profitability of CCF on peatlands limits its application in practice. The profitability of CCF was analyzed by simulating management scenarios with a process-based ecosystem model, EFIMOD, which was complemented to describe the interplay between tree growth and water table depth, which is typical of peatland forests. A variety of harvest intervals and post-harvest basal areas for a mature Norway spruce (Picea abies (L.) Karst.) dominated stand was simulated on a nutrient-rich peatland site. Conventional RF was simulated for comparison. CCF provided a higher profit than RF. The best financial performance was obtained with a 15-year harvest interval regardless of interest rate, although the overall profitability of CCF depended on the interest rate used. Ditch network maintenance was needed to maintain the stand growth only when the post-harvest basal area was smaller than 10 m2·ha−1. There were many CCF scenarios in which the difference in the net present value of harvest revenues was within 10% compared with the best CCF scenario. Hence, there are many relatively profitable CCF harvesting alternatives for forest management in boreal spruce-dominated peatland forests.
Chapter 7 Exploration implications
Authors: Wilson A. O. 
Published: November 2020

Abstract

Exploration of the Jurassic hydrocarbon system in the Arabian Intrashelf Basin area is in a mature state. Given the scale of the present day anticlinal structures and the adjacent synclines, all of the supergiant conventional fields trapped in huge anticlines have already been discovered. The theme throughout this Memoir has been to present the evolution of the self-contained Callovian–Tithonian Arabian Intrashelf Basin hydrocarbon system. Its size,
c.
1200 × 450 km, is greater than that of the UK, larger than the Black Sea and almost as large as Turkey or the area of Texas and New Mexico in the USA. It is geologically much simpler than these regions, both in the exceptionally remarkable continuity of facies within the sequences that developed and filled the intrashelf basin and its relative tectonic simplicity, including up to the present day. The cross-sections, facies maps, depositional profiles and other data and interpretations presented in this Memoir have documented this remarkable continuity. The source rock interval is well-defined everywhere it occurs and is mature; enough oil has been generated and migrated so that every sealed trap with reservoir facies will have oil. Around and within the basin, shallow water ramp facies in each sequence are in the reservoir facies and the early-formed porosity has been preserved. The carbonate seals and, even more so, the evaporite seals are remarkably laterally continuous. Therefore the big issue in future exploration is finding a sealed trap with potential reserves large enough to be worth drilling when compared to known reserves and estimates of future production. This chapter discusses some possibilities for stratigraphic traps and unconventional plays. Potential plays have been and/or can be identified, but finding them in the present day structural setting is likely to be very difficult.
Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma
Authors: Latham Alicia , Shia Jinru , Patel Zalak , Reidy-Lagunes Diane L. , Segal Neil H. , Yaeger Rona , Ganesh Karuna , Connell Louise , Kemeny Nancy E. , Kelsen David P. , Hechtman Jaclyn F. , Nash Garrett M. , Paty Philip B. , Zehir Ahmet , Tkachuk Kaitlin A. , Sheikh Rania , Markowitz Arnold J. , Mandelker Diana , Offit Kenneth , Berger Michael F. , Cercek Andrea , Garcia-Aguilar Julio , Saltz Leonard B. , Weiser Martin R. , Stadler Zsofia K. 
Published: November 2020

AbstractPurpose:The prevalence and clinical characteristics of small bowel adenocarcinomas (SBA) in the setting of Lynch syndrome have not been well studied. We characterized SBA according to DNA mismatch repair and/or microsatellite instability (MMR/MSI) and germline mutation status and compared clinical outcomes.Experimental Design:A single-institution review identified 100 SBAs. Tumors were evaluated for MSI via MSIsensor and/or corresponding MMR protein expression via IHC staining. Germline DNA was analyzed for mutations in known cancer predisposition genes, including MMR (MLH1, MSH2, MSH6, PMS2, and EPCAM). Clinical variables were correlated with MMR/MSI status.Results:Twenty-six percent (26/100; 95% confidence interval, 18.4–35.4) of SBAs exhibited MMR deficiency (MMR-D). Lynch syndrome prevalence was 10% overall and 38.5% among MMR-D SBAs. Median age at SBA diagnosis was similar in non-Lynch syndrome MMR-D versus MMR-proficient (MMR-P) SBAs (65 vs. 61; P = 0.75), but significantly younger in Lynch syndrome (47.5 vs. 61; P = 0.03). The prevalence of synchronous/metachronous cancers was 9% (6/67) in MMR-P versus 34.6% (9/26) in MMR-D SBA, with 66.7% (6/9) of these in Lynch syndrome (P = 0.0002). In the MMR-P group, 52.2% (35/67) of patients presented with metastatic disease, compared with 23.1% (6/26) in the MMR-D group (P = 0.008). In MMR-P stage I/II patients, 88.2% (15/17) recurred, compared with 18.2% (2/11) in the MMR-D group (P = 0.0002).Conclusions:When compared with MMR-P SBA, MMR-D SBA was associated with earlier stage disease and lower recurrence rates, similar to observations in colorectal cancer. With a 38.5% prevalence in MMR-D SBA, germline Lynch syndrome testing in MMR-D SBA is warranted.
Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better?
Authors: Strickler John H. , Hanks Brent A. , Khasraw Mustafa 
Published: November 2020

Abstract
Immune checkpoint inhibitors, including antibodies that block programmed cell death protein-1 (PD-1) and PD-L1, have transformed the management of many cancers. However, the majority of patients have primary or acquired resistance to these immunotherapies. There is a significant unmet need for predictive biomarkers that can reliably identify patients who derive a clinically meaningful response from PD-1/PD-L1 blockade. High tumor mutational burden (TMB-H) has shown promise as a biomarker in lung cancer, but the broad applicability of TMB-H as a biomarker of response across all solid tumors is unclear. The FDA has approved the PD-1 inhibitor, pembrolizumab, as a therapy for all solid tumors with TMB equal to or greater than 10 mutations/megabase as measured by the FoundationOne CDx assay. This approval was based on an exploratory analysis of the KEYNOTE-158 study, which was a single-arm, phase II multi-cohort study of pembrolizumab for select, previously treated advanced solid tumors. Here, we elucidate the caveats of using TMB as a biomarker with a universal threshold across all solid tumors. While we recognize the importance of this and other FDA pan-cancer approvals, several questions about TMB as a predictive biomarker remain unanswered. In this perspective, we discuss clinical trial evidence in this area. We review the relationship between TMB and the tumor immune microenvironment. We highlight the risks of extrapolating evidence from a limited number of tumor histologies to all solid tumors, and we propose avenues for future research.
Left Ventricular Magnetic Resonance Imaging Strain Predicts the Onset of Duchenne Muscular Dystrophy–Associated Cardiomyopathy
Authors: Siddiqui Saira , Alsaied Tarek , Henson Sarah E. , Gandhi Janvi , Patel Priyal , Khoury Philip , Villa Chet , Ryan Thomas D. , Wittekind Samuel G. , Lang Sean M. , Taylor Michael D. 
Published: November 2020

Background:
Early detection of left ventricular (LV) dysfunction before the onset of overt Duchenne muscular dystrophy–associated cardiomyopathy (DMDAC) may direct clinical management to slow onset of dysfunction. We aimed to assess whether LV strain will predict those who develop DMDAC.

Methods:
We performed a single center retrospective case control study of patients with Duchenne muscular dystrophy who underwent serial cardiac magnetic resonance between 2006 and 2019. Patients with Duchenne muscular dystrophy with an LV ejection fraction ≥55% on ≥1 cardiac magnetic resonance were identified and grouped into age-matched +DMDAC and –DMDAC. Within 3 years, +DMDAC had a subsequent cardiac magnetic resonance with a decline in LV ejection fraction ≥10% and absolute LV ejection fraction ≤50%. −DMDAC maintained an LV ejection fraction ≥55% on serial cardiac magnetic resonances. Two-dimensional and 3-dimensional global radial strain, global circumferential strain (GCS), and global longitudinal strain were measured using tissue tracking software and their ability to predict DMDAC onset was assessed. Multivariable analysis adjusted for late gadolinium enhancement.

Results:

Thirty +DMDAC and 30 age-matched −DMDAC patients were included with a total of 164 studies analyzed. Before DMDAC onset, 2-dimensional global radial strain and GCS were significantly worse in +DMDAC compared with −DMDAC (25.1±6.0 versus 29.0±6.3,
P
=0.011; −15.4%±2.4 versus −17.3%±2.6,
P
=0.003). Three-dimensional GCS and global radial strain had similar findings. Among strain measures, 3-dimensional GCS had the highest area under the curve to predict DMDAC in our cohort. These findings persisted after adjusting for the presence of late gadolinium enhancement.

Conclusions:
Reduced global radial strain and GCS may predict those at risk for developing DMDAC before onset of LV dysfunction and its clinical utility warrants further exploration.
Risk Factor Control and Cardiovascular Event Risk in People With Type 2 Diabetes in Primary and Secondary Prevention Settings
Authors: Wright Alison K. , Suarez-Ortegon Milton Fabian , Read Stephanie H. , Kontopantelis Evangelos , Buchan Iain , Emsley Richard , Sattar Naveed , Ashcroft Darren M. , Wild Sarah H. , Rutter Martin K. 
Published: November 2020

Background:
To examine the association between the degree of risk factor control and cardiovascular disease (CVD) risk in type 2 diabetes and to assess if the presence of cardio-renal disease modifies these relationships.

Methods:
A retrospective cohort study using data from English practices from CPRD GOLD (Clinical Practice Research Datalink) and the SCI-Diabetes dataset (Scottish Care Information-Diabetes), with linkage to hospital and mortality data. We identified 101 749 with type 2 diabetes (T2D) in CPRD matched with 378 938 controls without diabetes and 330 892 with type 2 diabetes in SCI-Diabetes between 2006 and 2015. The main exposure was number of optimized risk factors: nonsmoker, total cholesterol ≤4 mmol/L, triglycerides ≤1.7 mmol/L, glycated haemoglobin (HbA1c) ≤53 mmol/mol (≤7.0%), systolic blood pressure <140mm Hg, or <130 mm Hg if high risk. Cox models were used to assess cardiovascular risk associated with levels of risk factor control.

Results:
In CPRD, the mean baseline age in T2D was 63 years and 28% had cardio-renal disease (SCI-Diabetes: 62 years; 35% cardio-renal disease). Over 3 years follow-up (SCI-Diabetes: 6 years), CVD events occurred among 27 900 (27%) CPRD-T2D, 101 362 (31%) SCI-Diabetes-T2D, and 75 520 (19%) CPRD-controls. In CPRD, compared with controls, T2D participants with optimal risk factor control (all risk factors controlled) had a higher risk of CVD events (adjusted hazard ratio, 1.21; 95% confidence interval, 1.12–1.29). In T2D participants from CPRD and SCI-Diabetes, pooled hazard ratios for CVD associated with 5 risk factors being elevated versus optimal risk factor control were 1.09 (95% confidence interval, 1.01–1.17) in people with cardio-renal disease but 1.96 (95% confidence interval, 1.82–2.12) in people without cardio-renal disease. People without cardio-renal disease were younger and more likely to have suboptimal risk factor control but had fewer prescriptions for risk factor modifying medications than those with cardio-renal disease.

Conclusions:
Optimally managed people with T2D have a 21% higher CVD risk when compared with controls. People with T2D without cardio-renal disease would be predicted to benefit greatly from CVD risk factor intervention.
Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape
Authors: Bruijn Laura E. , van den Akker Brendy E. W. M. , van Rhijn Connie M. , Hamming Jaap F. , Lindeman Jan H. N. 
Published: November 2020

Background
Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as “fibroblasts,” “myofibroblasts,” “smooth muscle cells,” “fibrocytes,” “mesangial cells,” and “pericytes.” However, a discriminative marker‐based subclassification has to date not been established.

Methods and Results
As a first effort toward a classification scheme, a systematic literature search was performed to identify the most commonly used phenotypical and functional protein markers for characterizing and classifying vascular mesenchymal cell subpopulation(s). We next applied immunohistochemistry and immunofluorescence to inventory the expression pattern of identified markers on human aorta specimens representing early, intermediate, and end stages of human atherosclerotic disease. Included markers comprise markers for mesenchymal lineage (vimentin, FSP‐1 [fibroblast‐specific protein‐1]/S100A4, cluster of differentiation (CD) 90/thymocyte differentiation antigen 1, and FAP [fibroblast activation protein]), contractile/non‐contractile phenotype (α‐smooth muscle actin, smooth muscle myosin heavy chain, and nonmuscle myosin heavy chain), and auxiliary contractile markers (h1‐Calponin, h‐Caldesmon, Desmin, SM22α [smooth muscle protein 22α], non‐muscle myosin heavy chain, smooth muscle myosin heavy chain, Smoothelin‐B, α‐Tropomyosin, and Telokin) or adhesion proteins (Paxillin and Vinculin). Vimentin classified as the most inclusive lineage marker. Subset markers did not separate along classic lines of smooth muscle cell, myofibroblast, or fibroblast, but showed clear temporal and spatial diversity. Strong indications were found for presence of stem cells/Endothelial‐to‐Mesenchymal cell Transition and fibrocytes in specific aspects of the human atherosclerotic process.

Conclusions
This systematic evaluation shows a highly diverse and dynamic landscape for the human vascular mesenchymal cell population that is not captured by the classic nomenclature. Our observations stress the need for a consensus multiparameter subclass designation along the lines of the cluster of differentiation classification for leucocytes.
Dissimulitermes, a new soldierless termite genus (Blattaria: Isoptera: Termitidae: Apicotermitinae) from the Neotropics and the histology of its dehiscent organ
Authors: Constantini Joice , Janei Vanelize , Costa-Leonardo Ana Maria , Cancello Eliana M. 
Published: November 2020

Abstract
A new genus, Dissimulitermes Constantini & Cancello gen. nov., is described from the Neotropical region. The main morphological feature of the new genus is remarkable defensive organs. A new species of Dissimulitermes is described: D. invisibilis Constantini & Cancello, sp. nov. Description, comparisons, measurements, a distribution map, histology of their dehiscent organ, and an illustration of all the fundamental morphological aspects are provided.
A Rediscovered Almoravid Qurʾān in the Bavarian State Library, Munich (Cod. arab. 4)
Authors: Bongianino Umberto 
Published: November 2020

Abstract
This article examines and contextualizes a small Quranic manuscript, copied in al-Andalus in 533/1138–1139, whose importance has so far gone unrecognized. Among its many interesting features are: its early date; its lavish illumination; its colophon and the information contained therein; its system of notation and textual division; its use of different calligraphic styles, including Maghribī thuluth; and a series of didactic notes written at the beginning and end of the codex. Presented in the appendix is an updated list of the extant Qurʾāns in Maghribī scripts dated to before 600/1203–1204, aimed at encouraging the digitization, publication, and comparative study of this still largely uncharted material. The advancement of scholarship on the arts of the book, the transmission of the Qurʾān, and the consumption of Quranic manuscripts in the Islamic West depends upon the analysis of these and many other surviving codices and fragments, related to Cod. arab. 4 of the Bavarian State Library and its context of production.
The Human Intellect: Liberation or Limitation?
Authors: Ebstein Michael 
Published: November 2020

Abstract
The article discusses various attitudes towards the human intellect (ʿaql) in classical Islamic mysticism, as reflected in key mystical writings composed from the third/ninth century to the rise of Ibn al-ʿArabī in the sixth/twelfth. It begins by presenting the basic challenge that the concept of ʿaql posed for the mystics of Islam and then proceeds to analyze diverse approaches to the intellect in works that were written in both the east (mashriq) and the west (al-Andalus). Special attention is given to the impact of Neoplatonism on mystical attitudes towards the intellect. The conclusion to the article offers general observations on the problem of ʿaql in classical Islamic mysticism, and attempts to explain the tendency of certain sixth/twelfth-century mystics who were exposed to Neoplatonic thought to reduce the role of the intellect in the mystical quest for God.