bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teleassessment of Gait and Gait Aids: Validity and Interrater Reliability
Authors: Venkataraman Kavita , Amis Kristopher , Landerman Lawrence R , Caves Kevin , Koh Gerald C , Hoenig Helen 
Published: January 2020

AbstractBackgroundGait and mobility aid assessments are important components of rehabilitation. Given the increasing use of telehealth to meet rehabilitation needs, it is important to examine the feasibility of such assessments within the constraints of telerehabilitation.ObjectiveThe objective of this study was to examine the reliability and validity of the Tinetti Performance-Oriented Mobility Assessment gait scale (POMA-G) and cane height assessment under various video and transmission settings to demonstrate the feasibility of teleassessment.DesignThis repeated-measures study compared the test performances of in-person, slow motion (SM) review, and normal-speed (NS) video ratings at various fixed frame rates (8, 15, and 30 frames per second) and bandwidth (128, 384, and 768 kB/s) configurations.MethodsOverall bias, validity, and interrater reliability were assessed for in-person, SM video, and NS video ratings, with SM video rating as the gold standard, as well as for different frame rate and bandwidth configurations within NS videos.ResultsThere was moderate to good interrater reliability for the POMA-G (intraclass correlation coefficient [ICC] = 0.66–0.77 across all configurations) and moderate validity for in-person (β = 0.62; 95% confidence interval [CI] = 0.37–0.87) and NS video (β = 0.74; 95% CI = 0.67–0.80) ratings compared with the SM video rating. For cane height, interrater reliability was good (ICC = 0.66–0.77), although it was significantly lower at the lowest frame rate (8 frames per second) (ICC = 0.66; 95% CI = 0.54–0.76) and bandwidth (128 kB/s) (ICC = 0.69; 95% CI = 0.57–0.78) configurations. Validity for cane height was good for both in-person (β = 0.80; 95% CI = 0.62–0.98) and NS video (β = 0.86; 95% CI = 0.81–0.90) ratings compared with SM video rating.LimitationsSome lower frame rate and bandwidth configurations may limit the reliability of remote cane height assessments.ConclusionsTeleassessment for POMA-G and cane height using typically available internet and video quality is feasible, valid, and reliable.
Enthesitis in psoriatic arthritis (Part 1): pathophysiology
Authors: Araujo Elizabeth G , Schett Georg 
Published: January 2020

Abstract
Enthesitis is a key manifestation of PsA and current knowledge supports the concept that it may be among the primary events in the development of this disease, as well as other forms of SpA. Patients with PsA seem to have a different threshold to mechanical stress, which may be genetically determined. Hence patients with psoriatic disease respond pathologically with inflammation after being exposed to physiological mechanical stress. Activation of pro-inflammatory mediators such as IL-17 and TNF-α as well as the influx of innate immune cells are key events in the development of enthesitis in PsA. Chronic entheseal inflammation is accompanied by new bone formation, leading to bony spurs in peripheral (entheseophytes) and axial (syndesmophytes) structures. This article reviews the current knowledge on the mechanisms involved in the development of enthesitis in patients with PsA.
Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State
Authors: Sasabayashi Daiki , Takayanagi Yoichiro , Takahashi Tsutomu , Katagiri Naoyuki , Sakuma Atsushi , Obara Chika , Katsura Masahiro , Okada Naohiro , Koike Shinsuke , Yamasue Hidenori , Nakamura Mihoko , Furuichi Atsushi , Kido Mikio , Nishikawa Yumiko , Noguchi Kyo , Matsumoto Kazunori , Mizuno Masafumi , Kasai Kiyoto , Suzuki Michio 
Published: January 2020

Abstract
Previous structural magnetic resonance imaging studies of psychotic disorders have demonstrated volumetric alterations in subcortical (ie, the basal ganglia, thalamus) and temporolimbic structures, which are involved in high-order cognition and emotional regulation. However, it remains unclear whether individuals at high risk for psychotic disorders with minimal confounding effects of medication exhibit volumetric changes in these regions. This multicenter magnetic resonance imaging study assessed regional volumes of the thalamus, caudate, putamen, nucleus accumbens, globus pallidus, hippocampus, and amygdala, as well as lateral ventricular volume using FreeSurfer software in 107 individuals with an at-risk mental state (ARMS) (of whom 21 [19.6%] later developed psychosis during clinical follow-up [mean = 4.9 years, SD = 2.6 years]) and 104 age- and gender-matched healthy controls recruited at 4 different sites. ARMS individuals as a whole demonstrated significantly larger volumes for the left caudate and bilateral lateral ventricles as well as a smaller volume for the right accumbens compared with controls. In male subjects only, the left globus pallidus was significantly larger in ARMS individuals. The ARMS group was also characterized by left-greater-than-right asymmetries of the lateral ventricle and caudate nucleus. There was no significant difference in the regional volumes between ARMS groups with and without later psychosis onset. The present study suggested that significant volume expansion of the lateral ventricle, caudate, and globus pallidus, as well as volume reduction of the accumbens, in ARMS subjects, which could not be explained only by medication effects, might be related to general vulnerability to psychopathology.
Improving Team Functioning and Performance in Age-Diverse Teams: Evaluation of a Leadership Training
Authors: Jungmann Franziska , Wegge Jürgen , Liebermann Susanne C , Ries Birgit C , Schmidt Klaus-Helmut 
Published: January 2020

AbstractThe ongoing demographic change in most European countries increases the proportion of older employees and the prevalence of age diversity in work groups. As the diversity literature supports theories predicting negative effects of age diversity in teams, practical interest is growing how to influence these groups to perform at their best. In this article, we present a model of productivity in age-diverse teams, which we used as the platform for conceptualizing a new training for leaders. The training aims at improving attitudes toward older employees, appreciation of team diversity, and performance in age-diverse teams. We evaluated this training in a public administration in Germany with a training–waiting control group design (47 leaders, 221 employees) including a follow-up measure after 1 year. Results revealed that the training increased appreciation of age diversity and reduced age stereotypes in leaders. Team members’ ratings of age stereotypes and conflicts were also positively influenced, in particular for younger team members who suffer most from working in age-diverse teams. Thus, the newly developed training is a recommendable intervention for leaders of age-diverse teams.
The Effects of High-Fidelity Simulation, Low-Fidelity Simulation, and Video Training on Nursing Student Anxiety in the Clinical Setting
Authors: Thompson C. Elise 
Published: January 2020

Abstract
Education in medication administration is essential to patient safety, but there is limited evidence to describe the best way to influence clinical practice by nursing students. In a medication administration pilot study, the state anxiety of 44 nursing students was evaluated presimulation and prior to giving medications in the clinical setting. Two-way analysis of variance for repeated measures indicated no significant differences between high-fidelity simulation, low-fidelity simulation, or video training groups. However, high- and low-fidelity simulation led to decreased anxiety in the clinical setting, whereas video training led to greater anxiety.
Quality of Care and Outcomes of Patients With Gynecologic Malignancies Treated at Safety-Net Hospitals
Authors: Gamble Charlotte R. , Huang Yongmei , Tergas Ana I. , Khoury-Collado Fady , Hou June Y. , St Clair Caryn M. , Ananth Cande V. , Neugut Alfred I. , Hershman Dawn L. , Wright Jason D. 
Published: January 2020

(Abstracted from JNCI Cancer Spectr 2019;3(3):pkz039)
There are well-documented impacts of socioeconomic factors such as race and insurance status on outcomes for women with gynecologic malignancies; however, the role of hospital characteristics in modulating outcomes is less understood. Safety-net hospitals (SNHs), defined by the relative number of uninsured or Medicaid patients, play a critical role by serving the most vulnerable patients and improving access to care for many Americans.
Maternal and Neonatal Outcomes Associated With Trophectoderm Biopsy
Authors: Zhang Wendy Y. , von Versen-Höynck Frauke , Kapphahn Kristopher I. , Fleischmann Raquel R. , Zhao Qianying , Baker Valerie L. 
Published: January 2020

(Abstracted from Fertil Steril 2019;112:283–290.e2)
The use of preimplantation genetic testing (PGT) is increasing rapidly, having gone from 4% of all cycles in 2005 to over 22% in 2015. Despite this increasing use, maternal and neonatal outcomes for pregnancies achieved via in vitro fertilization (IVF) with PGT have very little assessment.
Is Traditional Perinatal Autopsy Needed After Detailed Fetal Ultrasound and Postmortem MRI?
Authors: Shelmerdine Susan C. , Arthurs Owen J. , Gilpin Isobel , Norman Wendy , Jones Rod , Taylor Andrew M. , Sebire Neil J. , Chitty Lyn S. 
Published: January 2020

(Abstracted from Prenat Diagn 2019;39:818–829)
Investigation after birth of fetal anomalies detected on prenatal ultrasound (US) is important, particularly after termination of pregnancy or fetal or perinatal loss, in terms of significant implications for genetic counseling, subsequent reproductive choices, and other family members. Confirmation of perinatal findings can traditionally be confirmed at a perinatal autopsy, but only 40% of parents consent to this procedure.
Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis
Authors: Korevaar Tim I. M. , Derakhshan Arash , Taylor Peter N. , Meima Marcel , Chen Liangmiao , Bliddal Sofie , Carty David M. , Meems Margreet , Vaidya Bijay , Shields Beverley , Ghafoor Farkhanda , Popova Polina V. , Mosso Lorena , Oken Emily , Suvanto Eila , Hisada Aya , Yoshinaga Jun , Brown Suzanne J. , Bassols Judith , Auvinen Juha , Bramer Wichor M. , López-Bermejo Abel , Dayan Colin , Boucai Laura , Vafeiadi Marina , Grineva Elena N. , Tkachuck Alexandra S. , Pop Victor J. M. , Vrijkotte Tanja G. , Guxens Mònica , Chatzi Leda , Sunyer Jordi , Jiménez-Zabala Ana , Riaño Isolina , Murcia Mario , Lu Xuemian , Mukhtar Shafqat , Delles Christian , Feldt-Rasmussen Ulla , Nelson Scott M. , Alexander Erik K. , Chaker Layal , Männistö Tuija , Walsh John P. , Pearce Elizabeth N. , Steegers Eric A. P. , Peeters Robin P. 
Published: January 2020

(Abstracted from JAMA 2019;322(7):632–641)
Preterm birth complicates 5% to 15% of births worldwide, and although it is the most important direct cause of morbidity and mortality in children younger than 5 years, no known risk factors can be identified in the majority of cases. However, overt hypothyroidism and hyperthyroidism during pregnancy are well-known risk factors for preterm birth, and as such, the purpose of this study was to assess whether thyroid function test abnormalities and thyroid peroxidase (TPO) antibody positivity were associated with preterm birth.
Can Ultrasound in Early Gestation Improve Visualization of Fetal Cardiac Structures in Obese Pregnant Women?
Authors: Majeed Amara , Abuhamad Alfred , Romary Letty , Sinkovskaya Elena 
Published: January 2020

(Abstracted from J Ultrasound Med 2019;38:2057–2063)
The worldwide obesity epidemic has led to more than 1.9 billion adults 18 years of age or older classified as “obese.” As obesity is associated with greater risk of maternal and feto-neonatal complications, this study aimed to assess the utility of early gestational ultrasounds (USs) in cardiac screening for obese patients. This entailed performing both late first-trimester/early second-trimester transvaginal and transabdominal US, in comparison with the current national guideline-based second-trimester abdominal US for initial fetal cardiac screening in obese patients.
What Is the Clinical Impact of the Endometrial Receptivity Array in PGT-A and Oocyte Donation Cycles?
Authors: Neves Ana Raquel , Devesa Marta , Martínez Francisca , Garcia-Martinez Sandra , Rodriguez Ignacio , Polyzos Nikolaos P. , Coroleu Buenaventura 
Published: January 2020

(Abstracted from J Assist Reprod Genet 2019;36:1901–1908)
Endometrial receptivity is a critical factor to likelihood of implantation after embryonic transfer (ET), yet potential biomarkers for receptivity have thus far failed at reliably predicting clinical pregnancy. Recent evidence has suggested that the Endometrial Receptivity Analysis (ERA), a microarray-based test to evaluate endometrial gene expression, may be valuable in prediction of endometrial receptivity and recommendation of endometrial preparation before ET.
Summative Assessment of Interprofessional “Collaborative Practice” Skills in Graduating Medical Students: A Validity Argument
Authors: Fraser Kristin L. , Charania Irina , Hecker Kent G. , Donahue Marlene , Kaba Alyshah , Veale Pamela , Coderre Sylvain , McLaughlin Kevin 
Published: January 2020

Purpose
To describe how the authors developed an objective structured clinical examination (OSCE) station to assess aspects of collaborative practice competency and how they then assessed validity using Kane’s framework.

Method
After piloting the collaborative practice OSCE station in 2015 and 2016, this was introduced at the Cumming School of Medicine in 2017. One hundred fifty-five students from the class of 2017 and 22 students from the class of 2018 participated. To create a validity argument, the authors used Kane’s framework that views the argument for validity as 4 sequential inferences on the validity of scoring, generalization, extrapolation, and implications,

Results
Scoring validity is supported by psychometric analysis of checklist items and the fact that the contribution of rater specificity to students’ ratings was similar to OSCE stations assessing clinical skills alone. The claim of validity of generalization is backed by structural equation modeling and confirmatory factor analysis that identified 5 latent variables, including 3 related to collaborative practice (“provides an effective handover,” “provides mutual support,” and “shares their mental model”). Validity of extrapolation is argued based upon the correlation between the rating for “shares their mental model” and the rating on in-training evaluations for “relationship with other members of the health care team,” in addition to the association between performance on the collaborative practice OSCE station and the subsequent rating of performance during residency. Finally, validity of implications is supported by the fact that pass/fail decisions on the collaborative practice station were similar to other stations and by the observation that ratings on different aspects of collaborative practice associate with pass/fail decisions.

Conclusions
Based upon the validity argument presented, the authors posit that this tool can be used to assess the collaborative practice competence of graduating medical students and the adequacy of training in collaborative practice.
The Relationship Between Clinical and Quantitative Measures of Pain Sensitization in Knee Osteoarthritis
Authors: Moore Rachel L. , Clifford Amanda M. , Moloney Niamh , Doody Catherine , Smart Keith M. , O’Leary Helen 
Published: January 2020

Objectives:
Pain sensitization in knee osteoarthritis (OA) is associated with greater symptom severity and poorer clinical outcomes. Measures that identify pain sensitization and are accessible to use in clinical practice have been suggested to enable more targeted treatments. This merits further investigation. This study examines the relationship between quantitative sensory testing (QST) and clinical measures of pain sensitization in people with knee OA.

Methods:
A secondary analysis of data from 134 participants with knee OA was performed. Clinical measures included: manual tender point count (MTPC), the Central Sensitization Inventory (CSI) to capture centrally mediated comorbidities, number of painful sites on a body chart, and neuropathic pain-like symptoms assessed using the modified PainDetect Questionnaire. Relationships between clinical measures and QST measures of pressure pain thresholds (PPTs), temporal summation, and conditioned pain modulation were investigated using correlation and multivariable regression analyses.

Results:
Fair to moderate correlations, ranging from −0.331 to −0.577 (P<0.05), were identified between MTPC, the CSI, number of painful sites, and PPTs. Fair correlations, ranging from 0.28 to 0.30 (P<0.01), were identified between MTPC, the CSI, number of painful sites, and conditioned pain modulation. Correlations between the clinical and self-reported measures and temporal summation were weak and inconsistent (0.09 to 0.25). In adjusted regression models, MTPC was the only clinical measure consistently associated with QST and accounted for 11% to 12% of the variance in PPTs.

Discussion:
MTPC demonstrated the strongest associations with QST measures and may be the most promising proxy measure to detect pain sensitization clinically.
Clinical Scenarios for Which Cervical Mobilization and Manipulation Are Considered by an Expert Panel to Be Appropriate (and Inappropriate) for Patients With Chronic Neck Pain
Authors: Herman Patricia M. , Vernon Howard , Hurwitz Eric L. , Shekelle Paul G. , Whitley Margaret D. , Coulter Ian D. 
Published: January 2020

Objectives:
Cervical mobilization and manipulation are 2 therapies commonly used for chronic neck pain (CNP). However, safety, especially of cervical manipulation, is controversial. This study identifies the clinical scenarios for which an expert panel rated cervical mobilization and manipulation as appropriate and inappropriate.

Methods:
An expert panel, following a well-validated modified-Delphi approach, used an evidence synthesis and clinical acumen to develop and then rate the appropriateness of cervical mobilization and manipulation for each of an exhaustive list of clinical scenarios for CNP. Key patient characteristics were identified using decision tree analysis (DTA).

Results:
Three hundred seventy-two clinical scenarios were defined and rated by an 11-member expert panel as to the appropriateness of cervical mobilization and manipulation. Across clinical scenarios more were rated inappropriate than appropriate for both therapies, and more scenarios were rated inappropriate for manipulation than mobilization. However, the number of patients presenting with each scenario is not yet known. Nevertheless, DTA indicates that all clinical scenarios that included red flags (eg, fever, cancer, inflammatory arthritides, or vasculitides), and some others involving major neurological findings, especially if previous manual therapy was unfavorable, were rated as inappropriate for both cervical mobilization and manipulation. DTA also identified the absence of cervical disk herniation, stenosis, or foraminal osteophytosis on additional testing as the most important patient characteristic in predicting ratings of appropriate.

Conclusions:
Clinical guidelines for CNP should include information on the clinical scenarios for which cervical mobilization and manipulation were found inappropriate, including those with red flags, and others involving major neurological findings if previous manual therapy was unfavorable.
Adherence to Consolidated Standards of Reporting Trials (CONSORT) Guidelines for Reporting Safety Outcomes in Trials of Medical Cannabis and Cannabis-based Medicines for Chronic Noncancer Pain
Authors: Mohiuddin Mohammed M. , Mizubuti Glenio B. , Haroutounian Simon , Smith Shannon M. , Rice Andrew S.C. , Campbell Fiona , Park Rex , Gilron Ian 
Published: January 2020

Objective:
Current treatments for chronic pain have limited effectiveness and tolerability. With growing interest in the potential of cannabinoids, there is a need to inform risk-benefit considerations. Thus, this focused systematic review assesses the quality of safety assessment and reporting in chronic noncancer pain cannabinoid trials.

Methods:
The protocol for this review has been published, and, registered in PROSPERO. We searched MEDLINE, Embase, The Cochrane Library, Scopus, and PsychINFO for double-blind, placebo-controlled, randomized controlled trials of cannabinoids for chronic pain, with a primary outcome related to pain. The primary review outcome is adherence to the 2004 Consolidated Standards of Reporting Trials (CONSORT) Harms extension. Secondary outcomes included type, reporting method, frequency and severity of adverse events (AEs), trial participant withdrawals, and reasons for withdrawals.

Results:
In total, 43 studies (4436 participants) were included. Type of cannabinoid (number of studies) included nabiximols (12), dronabinol (8), nabilone (7), oral cannabis extract preparations (5), smoked tetrahydrocannabinol (5), vaporized tetrahydrocannabinol (3), novel synthetic cannabinoids (2), sublingual cannabis extract preparations (1). The median CONSORT score was 7. On average, 3 to 4 recommendations of the CONSORT guidelines were not being met in trials. Seventeen trials did not provide their method of AE assessment, 14 trials did not report on serious AEs and, 7 trials provided no quantitative data about AEs.

Discussion:
Better harms assessment and reporting are needed in chronic pain cannabinoid trials. Improvements may be achieved through: expanded education/knowledge translation increased research regulation by ethics boards, funding agencies and journals, and greater emphasis on safety assessment and reporting throughout research training.