bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Interactions Between Thermal Piles Integrated in Building Foundations
Authors: Kwag Byung , Krarti Moncef 
Published: August 2020

Abstract
This paper investigates the impact of thermal interactions between heat exchangers integrated within building foundation piles to meet space heating and cooling needs of buildings. Specifically, a three-dimensional transient numerical model is developed to evaluate the thermal performance of the foundation piles. The model is used to estimate the temperature variations within the soil medium under various operation conditions of thermo-active foundation (TAF) systems. Then, a series of parametric analyses is carried out to evaluate the influence of design parameters of the piles on the performance of TAF systems, including the interactive effects between piles as well as the impact of these piles on the building slab heat transfer. Then, the parametric analysis results are utilized to develop simplified calculation methods to assess the thermal impacts of the geometric features for the piles on both the performance of TAF systems as well as the building slab heat losses and/or gains. The developed simplified calculation methods are suitable to develop design guidelines in order to enhance the performance of thermal piles to heat and cool buildings.
Experimental Evaluation in Thermal Conductivity Enhancement and Heat Transfer Optimization of Eco-Friendly Al2O3–Pure Coconut Oil Based Nano Fluids
Authors: Sujith S. V. , Solanki Anand Kumar , Mulik Rahul S. 
Published: August 2020

Abstract
The present study reports an experimental evaluation of thermal conductivity of Al2O3/pure coconut oil nano fluids with solid volume fraction varying from 0.1% to 1.2% at a temperature ranging from 303 K to 413 K, respectively. Additionally, the thermophysical properties such as thermal diffusivity, density, and specific heat were also measured. The effect of solid volume fraction and temperature on thermophysical properties of nano fluids was examined. The results confirmed that the thermal conductivity of nano fluids was higher than that of the base fluid with an increase in the solid volume fraction and temperature. Apart from this, the efficiency of nano fluids for the heat transfer application has been evaluated for optimization based on different figures of merit. Further, the experimental thermal conductivity data were compared with different existing models and correlations as the thermal conductivity enhancement of the nano fluid is directly or indirectly a function of almost all thermophysical properties. Hence, a novel dimensionless correlation was developed for predicting the thermal conductivity of pure coconut oil/Al2O3 nano fluids in terms of almost all the thermophysical parameters calculated from the experimental data.
Study on the Performance of a Y-Shaped Liquid Cooling Heat Sink Based on Constructal Law for Electronic Chip Cooling
Authors: Lu Zhihao , Zhang Kai 
Published: August 2020

Abstract
The power of one rack in a data center can be greater than 3 kW, which is released within a relatively small area. However, most of the heat in a data center is released from the electronic chips. Thus, the energy consumption of the air-conditioning system in a data center will be significantly decreased if the heat released by the electronic chips can be reduced directly. Although liquid cooling heat sinks (LCHS) have been demonstrated as an effective way to resolve this problem, the application of LCHS is limited by the uneven cooling distribution on the surface of the electronic chips and the liquid leakage of the LCHS. The constructal law optimizes the design of the pipeline by introducing the freedom of deformation in the fluid geometry to obtain the optimal global performance. In this study, a novel Y-shaped liquid cooling heat sink (YLCHS) was proposed based on the constructal law, in which the cooling water enters the center of the heat sink through the inlet pipe and diffuses into the periphery through the internal Y-shaped microchannels. A numerical simulation was carried out to determine the cooling effect of the YLCHS. Compared to those of the conventional S-shaped liquid cooling heat sink (CSLCHS), the peak surface temperature and the average surface temperature of the electronic chip with YLCHS were decreased by 15.2 °C and 6.3 °C, respectively. Furthermore, the pressure loss of the electronic chip with YLCHS was also reduced by 63.0%.
Pristine, Reduced, and Alkylated Graphene Oxide as Additives to Paraffin Grease for Enhancement of Tribological Properties
Authors: Rawat Sooraj Singh , Harsha A. P. , Khatri O. P. , Wäsche Rolf 
Published: August 2020

Abstract
Pristine, reduced, and alkylated graphene oxides are applied as lubricating additives in paraffin grease. It has revealed that their crystalline structure governs the tribological properties of grease for steel tribo-pair. The microstructural analyses of grease samples showed that a loose fiber network of soap in the presence of graphene-based additive allows their facile release for efficient lubrication. The surface analyses based on the microscopic and elemental mapping show the development of a graphene-derived protective film on the worn scars, which protected the tribo-surfaces and subsided the wear. The reduced graphene oxide (rGO) with the interlamellar distance of 0.35 nm in the (002) plane provided minimum resistance to shear and exhibited maximum reduction in coefficient of friction (COF) for the paraffin grease. The presence of oxygen functionalities in the basal of pristine and alkylated graphene oxide (GO) compromised the interlamellar shearing under tribo-stress; consequently, higher COF than that of rGO.
Overview: State-of-the Art Commercial Membranes for Anion Exchange Membrane Water Electrolysis
Authors: Henkensmeier Dirk , Najibah Malikah , Harms Corinna , Žitka Jan , Hnát Jaromír , Bouzek Karel 
Published: August 2020

AbstractOne promising way to store and distribute large amounts of renewable energy is water electrolysis, coupled with transport of hydrogen in the gas grid and storage in tanks and caverns. The intermittent availability of renewal energy makes it difficult to integrate it with established alkaline water electrolysis technology. Proton exchange membrane (PEM) water electrolysis (PEMEC) is promising, but limited by the necessity to use expensive platinum and iridium catalysts. The expected solution is anion exchange membrane (AEM) water electrolysis, which combines the use of cheap and abundant catalyst materials with the advantages of PEM water electrolysis, namely, a low foot print, large operational capacity, and fast response to changing operating conditions. The key component for AEM water electrolysis is a cheap, stable, gas tight and highly hydroxide conductive polymeric AEM. Here, we present target values and technical requirements for AEMs, discuss the chemical structures involved and the related degradation pathways, give an overview over the most prominent and promising commercial AEMs (Fumatech Fumasep® FAA3, Tokuyama A201, Ionomr Aemion™, Dioxide materials Sustainion®, and membranes commercialized by Orion Polymer), and review their properties and performances of water electrolyzers using these membranes.
Using Concentrating Solar Power to Create a Geological Thermal Energy Reservoir for Seasonal Storage and Flexible Power Plant Operation
Authors: Sharan Prashant , Kitz Kevin , Wendt Daniel , McTigue Joshua , Zhu Guangdong 
Published: August 2020

Abstract
We propose a hybrid renewable energy system—a geothermal energy storage system (GeoTES) with solar—to provide low-cost dispatchable power at various timescales from daily, to weekly, to seasonally. GeoTES with solar uses a concentrating solar power collector field to produce hot water that is injected into a sedimentary basin to create a synthetic geothermal resource. The stored geothermal heat can then be dispatched when required by the electrical grid. GeoTES is particularly valuable for a grid with a high penetration of non-flexible renewable technologies such as photovoltaic and wind power. In this work, a sophisticated hybrid model is developed to assess the technical and economic potential of GeoTES by combining IPSEpro, which is a power-cycle simulation tool, and SAM, an economic analysis tool by National Renewable Energy Laboratory (NREL). The analysis shows with proper initial charging period that the heat loss in storage is almost negligible and is a suitable technology for long-term energy storage. Various power-cycle options are evaluated, and the most suitable power cycle is selected for further study. Annual calculations of the GeoTES system indicate that a levelized cost of storage (LCOS) of 12.4 ¢/kWhe can be achieved for seasonal storage of 4000 h; this value is much lower than the existing long-term storage. The LCOS of GeoTES is insensitive to the storage duration above 8 h, unlike battery and molten-salt thermal storage systems. This result demonstrates that GeoTES can be a competitive seasonal storage technology in the future electricity market. The levelized cost of electricity of the GeoTES system is also carefully analyzed and can vary between 10.0 and 16.4 ¢/kWhe, depending on solar-collector prices.
Forearc magmatic evolution during subduction initiation: Insights from an Early Cretaceous Tibetan ophiolite and comparison with the Izu-Bonin-Mariana forearc
Authors: Dai Jin-Gen , Wang Cheng-Shan , Stern Robert J. , Yang Kai , Shen Jie 
Published: August 2020

Abstract
Subduction initiation is a key process in the operation of plate tectonics. Our understanding of melting processes and magmatic evolution during subduction initiation has largely been developed from studies of the Izu-Bonin-Mariana forearc. Many suprasubduction zone ophiolites are analogous to the Izu-Bonin-Mariana forearc sequence. However, whether there are differences between Izu-Bonin-Mariana subduction initiation sequences and suprasubduction zone ophiolites remains unclear. Here, we report field geological, geochemical, and geochronological data from mafic and felsic rocks in the Xigaze ophiolite (southern Tibet) mantle and crustal section; the same types of published data from both this ophiolite and the Izu-Bonin-Mariana forearc are compiled for comparison. The ophiolite section is intruded by various late-stage dikes, including gabbroic pegmatite, diabase, basalt, and plagiogranite. The compositions of clinopyroxene and amphibole suggest that gabbroic pegmatite formed from hydrous high-SiO2 depleted melts, while whole-rock compositions of basaltic and diabase dikes show negative Nb and Ta anomalies, suggesting flux melting of depleted mantle. Along with the mafic rocks, plagiogranite has a roughly constant content of La and Yb with increasing SiO2 contents, implying hydrous melting of mafic amphibolite. Early-stage pillow basalts exhibit geochemical affinities with Izu-Bonin-Mariana forearc basalts, but they are slightly enriched. Synthesized with the regional geological setting and compared with Izu-Bonin-Mariana forearc magmatism, we propose that the transition from mid-ocean ridge basalt–like lavas to subduction-related mafic and felsic dikes records an Early Cretaceous subduction initiation event on the southern flank of the Lhasa terrane. However, the mantle sources and the magmatic evolution in the Xigaze ophiolite are more variable than those for the Izu-Bonin-Mariana forearc.
Pulmonary embolism: update on management and controversies
Authors: Duffett Lisa , Castellucci Lana A , Forgie Melissa A 
Published: August 2020

ABSTRACTPulmonary embolism is a common and potentially fatal cardiovascular disorder that must be promptly diagnosed and treated. The diagnosis, risk assessment, and management of pulmonary embolism have evolved with a better understanding of efficient use of diagnostic and therapeutic options. The use of either clinical probability adjusted or age adjusted D-dimer interpretation has led to a reduction in diagnostic imaging to exclude pulmonary embolism. Direct oral anticoagulation therapies are safe, effective, and convenient treatments for most patients with acute venous thromboembolism, with a lower risk of bleeding than vitamin K antagonists. These oral therapeutic options have opened up opportunities for safe outpatient management of pulmonary embolism in selected patients. Recent clinical trials exploring the use of systemic thrombolysis in intermediate to high risk pulmonary embolism suggest that this therapy should be reserved for patients with evidence of hemodynamic compromise. The role of low dose systemic or catheter directed thrombolysis in other patient subgroups is uncertain. After a diagnosis of pulmonary embolism, all patients should be assessed for risk of recurrent venous thromboembolism to guide duration of anticoagulation. Patients with a venous thromboembolism associated with a strong, transient, provoking risk factor can safely discontinue anticoagulation after three months of treatment. Patients with an ongoing strong risk factor, such as cancer, or unprovoked events are at increased risk of recurrent events and should be considered for extended treatment. The use of a risk prediction score can help to identify patients with unprovoked venous thromboembolism who can benefit from extended duration therapy. Despite major advances in the management of pulmonary embolism, up to half of patients report chronic functional limitations. Such patients should be screened for chronic thromboembolic pulmonary hypertension, but only a small proportion will have this as the explanation of their symptoms. In the remaining patients, future studies are needed to understand the pathophysiology and explore interventions to improve quality of life.
Prospective study of 5-day challenge with penicillins in children
Authors: Petersen Birgitte Tusgaard , Gradman Josefine 
Published: August 2020

ObjectivesTo examine if a 5-day challenge with penicillin improves the diagnostic sensitivity compared with a single full dose in children with mild skin reactions.DesignSubjects referred with suspected allergy to penicillin were consecutively included. Irrespectively of the morphology of the index reaction and the result of specific IgE, all subjects underwent a two-step titrated drug provocation test (DPT) with the culprit drug followed by a 5-day challenge at home.ParticipantsChildren and adolescents aged 0–18 years referred to allergic workup for penicillin hypersensitivity at two paediatric Danish centres. Only subjects with non-severe skin reactions were included.ResultsA total of 305 subjects were included and 22 (7%) of the DPTs were positive. Three subjects reacted within 1 hour of the first full dose and nine reacted 1–8 hours after the first full dose. Additional 10 positive reactions were observed during the prolonged provocation. Seven subjects reacted after the second full dose and three reacted after 3–6 days. Only mild skin rashes were observed. Eighteen subjects had a specific IgE to a penicillin >0.1 kU/L. Only one of these had a positive DPT.ConclusionIn children, a DPT with penicillins should include at least two full doses. In children with mild hypersensitivity reactions it may be safe to perform DPTs despite a low specific IgE.Trial registration numberNCT04331522
Effectiveness of isometric exercise in the management of tendinopathy: a systematic review and meta-analysis of randomised trials
Authors: Clifford Christopher , Challoumas Dimitris , Paul Lorna , Syme Grant , Millar Neal L 
Published: August 2020

ObjectiveTo systematically review and critically appraise the literature on the effectiveness of isometric exercise in comparison with other treatment strategies or no treatment in tendinopathy.DesignA systematic review and meta-analysis of randomised controlled trials.Data sourcesElectronic searches of Medline, Cumulative Index to Nursing and Allied Health Literature, EMBASE and Cochrane were undertaken from inception to May 2020.MethodsOverall quality of each study was determined based on a combined assessment of internal validity, external validity and precision. For each outcome measure, level of evidence was rated based on the system by van Tulderet al.ResultsTen studies were identified and included in the review, including participants with patellar (n=4), rotator cuff (n=2), lateral elbow (n=2), Achilles (n=1) and gluteal (n=1) tendinopathies. Three were of good and seven were of poor overall quality. Based on limited evidence (level 3), isometric exercise was not superior to isotonic exercise for chronic tendinopathy either immediately following treatment or in the short term (≤12 weeks) for any of the investigated outcome measures. Additionally, for acute rotator cuff tendinopathy, isometric exercise appears to be no more effective than ice therapy in the short term (limited evidence; level 3).SummaryIsometric exercise does not appear to be superior to isotonic exercise in the management of chronic tendinopathy. The response to isometric exercise is variable both within and across tendinopathy populations. Isometric exercise can be used as part of a progressive loading programme as it may be beneficial for selected individuals.PROSPERO registration numberCRD42019147179.
Observational study of the association between diverse licensed premises types and alcohol-related violence in an inner-London borough
Authors: Boshari Talia , Sharpe Carolyn A , Poots Alan J , Watt Hillary , Rahman Saifur , Pinder Richard J 
Published: August 2020

BackgroundAn ecological correlation has been observed between licensed premises and alcohol-related violence (ARV). In the UK to date, no evidence directly connects alcohol-related harm to a single premises type. Recent policies have called for a diversified alcohol offer, yet quantitative evidence in support remains sparse. This study aims to inform policy by determining whether diversification of the alcohol economy is desirable and to inform the licensing process and submission of public health evidence.MethodsUsing 11 years of local licensing data from the London Borough of Southwark, alcohol availability over time was approximated by the number of extant alcohol licences, categorised by outlet type: drinking establishments, eateries, takeaways, off-sales and ‘other’. Harm was quantified drawing on law enforcement intelligence that recorded ARV. A linked data set was analysed using negative binomial regression, contrasting cumulative impact zones (CIZ)—a common alcohol control policy—with non-CIZ geographies.ResultsEach licensed drinking establishment was associated with a 1.6% (95% CI 0.7% to 2.6%; p=0.001) increase in ARV, respectively. ‘Other’ outlets had a protective effect and were associated with a 1.8% (95% CI 1.0% to 2.5%; p<0.001) decrease in ARV.ConclusionThis study provides direct evidence for an association between alcohol-related harm and licensed premises. The varying associations between outlet type and ARV provide local public health stakeholders with an evidence base upon which to advocate for licensing policies that diversify alcohol availability.
PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer
Authors: Shen Yang , Teng Yongsheng , Lv Yipin , Zhao Yongliang , Qiu Yuan , Chen Weisan , Wang Lina , Wang Ying , Mao Fangyuan , Cheng Ping , Ma Daiyuan , Zhuang Yuan , Zou Quanming , Peng Liusheng 
Published: August 2020

BackgroundOverexpression of programmed cell death protein 1 (PD-1) is linked to CD8+ T cell dysfunction and contributes to tumor immune escape. However, the prevalence and functional regulations of PD-1 expression on CD8+ T cells in human gastric cancer (GC) remain largely unknown.MethodsFlow cytometry was performed to analyze the level, phenotype, functional and clinical relevance of PD-1+CD8+ T cells in GC patients. Peripheral blood CD8+ T cells were purified and subsequently exposed to culture supernatants from digested primary GC tumor tissues (TSN) in vitro for PD-1 expression and functional assays. Tumor responses to adoptively transferred TSN-stimulated CD8+ T cells or to the TSN-stimulated CD8+ T cell transfer combined with an anti-PD-1 antibody injection were measured in an in vivo xenograft mouse model.ResultsGC patients’ tumors showed a significantly increased PD-1+CD8+ T cell infiltration. However, these GC-infiltrating PD-1+CD8+ T cells showed equivalent function to their PD-1−CD8+ counterparts and they did not predict tumor progression. High level of transforming growth factor-β1 (TGF-β1) in tumors was positively correlated with PD-1+CD8+ T cell infiltration, and in vitro GC-derived TGF-β1 induced PD-1 expression on CD8+ T cells via Smad3 signaling, whereas Smad2 signaling was involved in GC-derived TGF-β1-mediated CD8+ T cell dysfunction. Furthermore, GC-derived TGF-β1-mediated CD8+ T cell dysfunction contributed to tumor growth in vivo that could not be attenuated by PD-1 blockade.ConclusionsOur data highlight that GC-derived TGF-β1 promotes PD-1 independent CD8+ T cell dysfunction. Therefore, restoring CD8+ T cell function by a combinational PD-1 and TGF-β1 blockade might benefit future GC immunotherapy.
Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p
Authors: Guiot Julien , Cambier Maureen , Boeckx Amandine , Henket Monique , Nivelles Olivier , Gester Fanny , Louis Edouard , Malaise Michel , Dequiedt Franck , Louis Renaud , Struman Ingrid , Njock Makon-Sébastien 
Published: August 2020

IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology and cure. Recent studies have reported a dysregulation of exosomal microRNAs (miRs) in the IPF context. However, the impact of IPF-related exosomal miRs on the progression of pulmonary fibrosis is unknown.MethodsTwo independent cohorts were enrolled at the ambulatory care polyclinic of Liège University. Exosomes from sputum were obtained from 19 patients with IPF and 23 healthy subjects (HSs) (cohort 1), and the ones from plasma derived from 14 patients with IPF and 14 HSs (cohort 2). Exosomal miR expression was performed by quantitative reverse transcription–PCR. The functional role of exosomal miRs was assessed in vitro by transfecting miR mimics in human alveolar epithelial cells and lung fibroblasts.ResultsExosomal miR analysis showed that miR-142-3p was significantly upregulated in sputum and plasma of patients with IPF (8.06-fold, p<0.0001; 1.64 fold, p=0.008, respectively). Correlation analysis revealed a positive association between exosomal miR-142-3p and the percentage of macrophages from sputum of patients with IPF (r=0.576, p=0.012), suggesting macrophage origin of exosomal miR-142-3p upregulation. The overexpression of miR-142-3p in alveolar epithelial cells and lung fibroblasts was able to reduce the expression of transforming growth factor β receptor 1 (TGFβ-R1) and profibrotic genes. Furthermore, exosomes isolated from macrophages present antifibrotic properties due in part to the repression of TGFβ-R1 by miR-142-3p transfer in target cells.DiscussionOur results suggest that macrophage-derived exosomes may fight against pulmonary fibrosis progression via the delivery of antifibrotic miR-142–3 p to alveolar epithelial cells and lung fibroblasts.