bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults
Authors: Kellerová Pavlína , Raisová Stuchlíková Lucie , Matoušková Petra , Štěrbová Karolína , Lamka Jiří , Navrátilová Martina , Vokřál Ivan , Szotáková Barbora , Skálová Lenka 
Published: July 2020

AbstractThe efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g. cytochromes P450 (CYPs), UDP-glycosyltransferases (UGTs) and P-glycoprotein transporters (P-gps), in comparison to sensitive isolates have been described. However, the mechanisms and circumstances of DMEs induction are not well known. Therefore, the present study was designed to find the changes in expression of CYPs, UGTs and P-gps in adult parasitic nematodes Haemonchus contortus exposed to sub-lethal doses of the benzimidazole anthelmintic drug albendazole (ABZ) and its active metabolite ABZ-sulfoxide (ABZSO). In addition, the effect of ABZ at sub-lethal doses on the ability to deactivate ABZ during consequent treatment was studied. The results showed that contact of H. contortus adults with sub-lethal doses of ABZ and ABZSO led to a significant induction of several DMEs, particularly cyp-2, cyp-3, cyp-6, cyp-7, cyp-8, UGT10B1, UGT24C1, UGT26A2, UGT365A1, UGT366C1, UGT368B2, UGT367A1, UGT371A1, UGT372A1 and pgp-3, pgp-9.1, pgp-9.2, pgp-10. This induction led to increased formation of ABZ metabolites (especially glycosides) and their increased export from the helminths’ body into the medium. The present study demonstrates for the first time that contact of H. contortus with sub-lethal doses of ABZ (e.g. during underdose treatment) improves the ability of H. contortus adults to deactivate ABZ in consequent therapy.
The experiences of family caregivers living with breast cancer patients in low-and middle-income countries: a systematic review
Authors: Kusi Grace , Boamah Mensah Adwoa Bemah , Boamah Mensah Kofi , Dzomeku Veronica Millicent , Apiribu Felix , Duodu Precious Adade , Adamu Bakinam , Agbadi Pascal , Bonsu Kwadwo Osei 
Published: July 2020

AbstractIntroductionCaregivers of women with breast cancer in low-and-middle-income countries experience significant physical and economic burdens. The review aimed to map the evidence of studies that had reported on the experiences of family caregivers of women diagnosed with breast cancer.MethodsA systematic literature search was conducted in CINAHL, PubMed, PsycINFO, Scopus, and Web of Science databases using a combination of key search terms and medical subject heading terms such as “family caregiver,” “breast cancer,” “home care,” “low-and-middle-income countries,” “experience,” “effect,” and “coping mechanism.” A total of 1781 articles were retrieved and screened. Nineteen studies addressing caregiving experiences were included in the final review based on the inclusion and exclusion criteria.ResultsThe systematic review yielded 19 studies that focused on caregivers’ motivation, needs of caregivers, intervention for caregivers, and consequences of caregiving. The most significant correlates of the quality of life among caregivers were disease severity, functional status of patients, and family income. The challenges encountered by caregivers were mostly psychosocial.ConclusionsCaregivers play a crucial role in the management of women with breast cancer. However, they are faced with increasing challenges in their caregiving roles. Understanding the nature and extent of the burden experienced by family caregivers in developing countries will facilitate the development of appropriate interventions that can help improve caregivers’ quality of life. Gaps in recent studies were identified, and suggestions for future research were also addressed in this review.Systematic review registrationPROSPERO CRD42019118391
Stability, bifurcation, and chaos control of a novel discrete-time model involving Allee effect and cannibalism
Authors: Shabbir Muhammad Sajjad , Din Qamar , Ahmad Khalil , Tassaddiq Asifa , Soori Atif Hassan , Khan Muhammad Asif 
Published: July 2020

AbstractThis paper is related to some dynamical aspects of a class of predator–prey interactions incorporating cannibalism and Allee effects for non-overlapping generations. Cannibalism has been frequently observed in natural populations, and it has an ability to alter the functional response concerning prey–predator interactions. On the other hand, from dynamical point of view cannibalism is considered as a procedure of stabilization or destabilization within predator–prey models. Taking into account the cannibalism in prey population and with addition of Allee effects, a new discrete-time system is proposed and studied in this paper. Moreover, existence of fixed points and their local dynamics are carried out. It is verified that the proposed model undergoes transcritical bifurcation about its trivial fixed point and period-doubling bifurcation around its boundary fixed point. Furthermore, it is also proved that the proposed system undergoes both period-doubling and Neimark–Sacker bifurcations (NSB) around its interior fixed point. Our study demonstrates that outbreaks of periodic nature may appear due to implementation of cannibalism in prey population, and these periodic oscillations are limited to prey density only without leaving an influence on predation. To restrain this periodic disturbance in prey population density, and other fluctuating and bifurcating behaviors of the model, various chaos control methods are applied. At the end, numerical simulations are presented to illustrate the effectiveness of our theoretical findings.
The energy potential of soft rush (Juncus effusus L.) in different conversion routes
Authors: Müller Jürgen , Jantzen Christian , Wiedow Denny 
Published: July 2020

Abstract
Background
Rushes are prominent wetland plants that are well adapted to conditions of waterlogging. Tall rushes like soft rush (Juncus effusus L.) tend to dominate the vegetation and offer a great biomass potential. Removing rush biomass is often necessary to enhance various ecosystem services of wetlands. There is an urgent need for sustainable use of the removed biomass apart from expensive composting ore useless landfill.

Methods
We investigated three alternative energy utilisation routes for soft rush biomass and evaluated their energetic potential: biomethanisation via wet fermentation technique (a), biomethanisation via solid-state fermentation technique (b) and combustion (c). Batch experiments (a), experimental fermenters (b), and thermo-calorimetric equipment (c) were used to measure energy output per unit rush biomass input.

Results
The wet fermentation technique had significantly higher biogas yields than solid-state fermentation (399 LN kg−1 oDM compared to 258 LN kg−1 oDM). These yields constitute 59 and 43%, respectively, of the biogas potential of maize silage as a reference. Solid-state fermentation technique needs longer retention time compared to wet co-digestion to earn comparable methane yields. Soft rush biomass shows high heating values (15.06 MJ kg FMw15−1) compared to other herbaceous solid fuels.

Conclusions
Low costs for substrate production make energetic utilisation of Juncus effusus an interesting alternative, if short distances between fields and biomass conversion plant can be realised. All investigated conversion routes appear promising, provided that the substrate specifics are considered in the design of the conversion technique. Besides the size of the rush dominated area and the distribution of these areas in the landscape, the investment costs and the subsidies for the conversion plant play a pivotal role in the selection of the preferred conversion path.
A global view of regulatory ecosystem services: existed knowledge, trends, and research gaps
Authors: Mengist Wondimagegn , Soromessa Teshome , Feyisa Gudina Legese 
Published: July 2020

AbstractEcosystem services (ES) are growing fields of research. It helps to provide an inherent way to understand the synergy and trade-offs between human beings and their natural environment. Regulatory ecosystem services (RES) are significantly important to maintaining the world in which people can live, and control the negative effects of flood, disasters, and diseases. It can also provide regulatory services like ecosystem protection, human safety, and the provision of other ES. However, emerging ES decision-making agendas focus on ES that is tangible and has a direct link with human well-being. Thus, the attention given to RES is low due to its less tangible benefits and complexity to measure the benefits. Disregarding and lack of attention from policymakers and scientific community may lead to unintended risks to human well-being and significant influences on the provision of other ES. This study describes the research trends on RES, knowledge generated, and the major limitation. We concluded that though there is an exponential growth of scientific publications on ES, no adequate studies were found on RES. Also, the existed studies varied in their size and types of RES indicators covered, habitats/ecosystems, and geographic extent addressed. There was also a lack of connecting knowledge generated on the benefits of RES with the national policy of natural resource management, inconsistency of ES classification, and methodological diversity. Therefore, scientific communities are promoted to link RES studies with human health. Besides, the researcher should give priority for the least studied ecosystems and its services, developing robust methodology, and proposing management options to enhance the regulatory services of ecosystems.
Selecting critical features for data classification based on machine learning methods
Authors: Chen Rung-Ching , Dewi Christine , Huang Su-Wen , Caraka Rezzy Eko 
Published: July 2020

AbstractFeature selection becomes prominent, especially in the data sets with many variables and features. It will eliminate unimportant variables and improve the accuracy as well as the performance of classification. Random Forest has emerged as a quite useful algorithm that can handle the feature selection issue even with a higher number of variables. In this paper, we use three popular datasets with a higher number of variables (Bank Marketing, Car Evaluation Database, Human Activity Recognition Using Smartphones) to conduct the experiment. There are four main reasons why feature selection is essential. First, to simplify the model by reducing the number of parameters, next to decrease the training time, to reduce overfilling by enhancing generalization, and to avoid the curse of dimensionality. Besides, we evaluate and compare each accuracy and performance of the classification model, such as Random Forest (RF), Support Vector Machines (SVM), K-Nearest Neighbors (KNN), and Linear Discriminant Analysis (LDA). The highest accuracy of the model is the best classifier. Practically, this paper adopts Random Forest to select the important feature in classification. Our experiments clearly show the comparative study of the RF algorithm from different perspectives. Furthermore, we compare the result of the dataset with and without essential features selection by RF methodsvarImp(),Boruta, and Recursive Feature Elimination (RFE) to get the best percentage accuracy and kappa. Experimental results demonstrate that Random Forest achieves a better performance in all experiment groups.
Original composition and formation process of slab-derived deep brine from Kashio mineral spring in central Japan
Authors: Kusuhara Fumitake , Kazahaya Kohei , Morikawa Noritoshi , Yasuhara Masaya , Tanaka Hidemi , Takahashi Masaaki , Tosaki Yuki 
Published: July 2020

AbstractBrine samples from the wells in the Kashio mineral spring (an “Arima-type” hot spring at Ooshika-Mura, central Japan) were analyzed to determine the original chemical and isotopic compositions of the deep brine end-member before its dilution by meteoric water and to elucidate the origin of the end-member. The trends of variation between Cl, δD, and δ18O indicated the existence of a two-component mixing system and a systematic variation in the mixing ratio, which were mentioned in previous studies. By carefully tracking the variation in tritium (3H) and atmospheric noble gas in the brine, the Cl concentration in the end-member was determined to be 24,000 mg/L. This value is consistent with the result of previous studies. Based on the estimated composition and other related data, we inferred that the end-member originated from slab-derived fluid, which in turn may have undergone oxygen isotope exchange reactions with minerals. Although both the Arima and Kashio brines are considered to be derived from fluid dehydrated from the Philippine Sea slab, the chemical and isotopic compositions of the Kashio end-member are different from those of the Arima end-member. In particular, the Kashio end-member is characterized by low Cl concentration (~ 40% lower than that in the Arima end-member), low hydrogen isotope ratio, and low 3He/4He ratio (1.4 Ra). These results indicate that the chemical and isotopic compositions of the slab-derived fluid are different for each location. The significant difference in δD could reflect the difference in the dehydration depth. Finally, the low temperature and relatively low 3He/4He ratio of the brine end-member could be explained by its long residence time within the crust.
Laboratory investigation of earthquake lightning due to landslide
Authors: Enomoto Yuji , Yamabe Tsuneaki , Mizuhara Kazuyuki , Sugiura Shigeki , Kondo Hitoshi 
Published: July 2020

AbstractSeveral laboratory experimental studies of photoemission characteristics of rocks as they fracture have been conducted to elucidate the mechanism of earthquake lightning (EQL). In most of these studies, granite, which exhibits remarkable photoemission, is widely used to explain the mechanism attributed to the exoelectron emission effect or piezo-induced effect of quartz, a constituent mineral of granite. Photoemission induced by rock fracturing has been observed prominently during landslides caused by earthquakes. According to the literature on historical earthquakes, landslide-induced EQL was witnessed even at locations where quartz was not present. In this study, we therefore studied the physicochemical characteristics of photoemissions associated with impact shear fractures in various rocks, selected based on historical earthquake records of landslide EQL. As a result, we could highlight various physicochemical processes associated with the frictional heating generated during shear impacts between rocks.
Effects of intensive care unit ambient sounds on healthcare professionals: results of an online survey and noise exposure in an experimental setting
Authors: Schmidt Nadine , Gerber Stephan M. , Zante Björn , Gawliczek Tom , Chesham Alvin , Gutbrod Klemens , Müri René M. , Nef Tobias , Schefold Joerg C. , Jeitziner Marie-Madlen 
Published: July 2020

Abstract
Background
Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-being or performance in healthcare professionals.

Methods
An online survey in the German-speaking part of Switzerland was conducted to assess how ICU soundscapes are subjectively perceived by healthcare professionals. The questionnaire was answered by 348 participants. Additionally, effects of noise on working memory performance were evaluated in an experimental noise exposure setting. Twenty-six healthcare professionals and 27 healthy controls performed a 2-back object-location task while being exposed to either ICU or pink noise.

Results
Survey results demonstrate that a majority of participants was aware of heightened noise levels. Participants reported that mostly well-being, performance, and attention could be reduced, along with subjective annoyance and fatigue by ICU ambient sounds. Although no significant effects of noise exposure on working memory performance was observed, self-assessments revealed significantly higher stress levels, increased annoyance and distraction ratings as well as decreased confidence in performance after ICU-noise exposure.

Conclusion
Subjective assessments indicate that heightened noise levels on ICUs induce annoyance, with heightened stress levels, impaired well-being, and reduced performance being potential consequences. Empirical evidence with objective and physiological measures is warranted.
A case of endosalpingiosis in the lymph nodes of the mesocolon
Authors: Niwa Koichiro , Sakamoto Kazuhiro , Goto Michitoshi , Kojima Yutaka , Takahashi Makoto , Ishiyama Shun , Kawai Masaya , Okazawa Yuu , Tomita Natumi , Seki Eiichiro , Fukumura Yuki , Yao Takashi 
Published: July 2020

Abstract
Background
Endosalpingiosis in the lymph nodes of the mesocolon is very rare. We reported a case with appendiceal endometriosis who had endosalpingiosis in the lymph nodes of the mesocolon that was found during laparoscopic ileocecal resection.

Case presentation
The patient was a 44-year-old woman who had visited a physician for fever, bloody stool, and abdominal pain 1 year earlier. She was diagnosed with ulcerative colitis on colonoscopy, and symptoms improved with oral treatment. A colonoscopy performed 2 months after diagnosis detected a hard, 20-mm submucosal tumor (SMT) in the cecum. On abdominal contrast CT, an intensely stained mass, including a low-density region, was observed in the cecum. A boring biopsy was performed after mucosal resection of the cecal SMT at our hospital, but diagnosis could not be made. Since the possibility of a malignant lesion could not be ruled out, laparoscopic ileocecal resection was performed. In the resected specimen, a 29 × 27 × 21-mm mass was present in the appendicular root. On histopathological examination, appendiceal endometriosis and endosalpingiosis in the lymph nodes around the ileocolic artery were observed. The postoperative course was favorable, and the patient was discharged 7 days after surgery.

Conclusion
Differentiation of endosalpingiosis in lymph nodes in the mesocolon from lymph node metastasis of adenocarcinoma is important in patients with an abdominal mass.
Zotepine loaded lipid nanoparticles for oral delivery: development, characterization, and in vivo pharmacokinetic studies
Authors: Nagaraj B. , Tirumalesh C. , Dinesh S. , Narendar D. 
Published: July 2020

Abstract
Background
The purpose of this work was to prepare and evaluate the zotepine (ZT) loaded solid lipid nanoparticles (SLNs) that might improve the oral bioavailability. ZT is an anti-psychotic drug used for the treatment of schizophrenia. Currently, it is available as parenteral and oral dosage form. But, ZT has a poor oral bioavailability of about 7–13% due to limited aqueous solubility and first-pass effect. ZT-SLNs were developed using homogenization method and characterized for optimal system based on physicochemical characteristics and in vitro release. The optimized ZT-SLNs were evaluated for permeation through rat intestine using evert sac method. The crystalline nature of the ZT-SLNs was studied using DSC and XRD analysis. Surface morphology studies were conducted using SEM. Physical stability of the optimized ZT-SLN was evaluated at refrigerator and room temperature over 2 months. Further, pharmacokinetic (PK) studies of ZT-SLN were conducted in male Wistar rats, in comparison with ZT coarse suspension (ZT-CS), in vivo.

Results
Among all the developed ZT-SLN formulations, optimized formulation (F1) showed Z-avg, PDI, and ZP of 104.3 ± 1.6 nm, 0.17 ± 0.01, and − 30.5 ± 2.5 mV, respectively. In vitro release and permeation studies exhibited 82.9 ± 1.6% of drug release and 19.6 ± 2.1% of percentage drug permeation over 48 h and 120 min, respectively. DSC and XRD studies revealed the conversion of ZT to amorphous form. SEM studies showed spherical shape with improved PDI of ZT-SLN formulation. PK studies showed a significant (p < 0.05) improvement in AUC of about 1.3-fold, in comparison with ZT-CS in Wistar rats.

Conclusion
Therefore, the results concluded that SLNs could be considered as a new alternative delivery system for the enhancement of oral bioavailability of ZT.
Anatomical Evaluation of a Conventional Pectoralis II Versus a Subserratus Plane Block for Breast Surgery
Authors: Robinson Hal , Mishra Shailendra , Davies Lauren , Craigen Fiona , Vilcina Vija , Parson Simon , Shahana Shahida 
Published: July 2020

BACKGROUND:
Pectoralis I and II (Pecs I/Pecs II) blocks are modern regional anesthetic techniques performed in combination to anesthetize the nerves involved in breast surgery and axillary node dissection. Pecs II spread and clinical efficacy is thought to be independent of whether injection occurs between pectoralis minor and serratus anterior or deep to serratus anterior. Injecting deep to serratus anterior onto the rib may be technically easier; however, our clinical experience suggests that this approach may be less effective for axillary dissection. We undertook a cadaveric study to evaluate a subserratus plane approach for use in breast and axillary surgery.

METHODS:
Ultrasound-guided blocks using methylene blue dye were performed on 4 Genelyn-embalmed cadavers to assess and compare dye spread after a conventional Pecs II and a subserratus plane block at the third rib.

RESULTS:
Conventional Pecs II injection demonstrated staining of the intercostobrachial nerve, third intercostal nerve, thoracodorsal nerve, long thoracic nerve, medial pectoral, and lateral pectoral nerve. The subserratus plane produced significantly less axillary spread, incomplete staining of the medial pectoral, and very minimal staining of the lateral pectoral nerve. Dye spread was limited to the lateral cutaneous branches of the intercostal nerves in both injections.

CONCLUSIONS:
In our cadaveric study, injecting deep to serratus plane produced significantly less axillary spread. For breast surgery excluding the axilla, both techniques may be effective; however, for axillary dissection, the conventional Pecs II is likely to produce superior analgesia and additionally may help achieve complete coverage of the deeper pectoral nerve branches.