bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding and assessing uncertainty of observational climate datasets for model evaluation using ensembles
Authors: Zumwald Marius , Knüsel Benedikt , Baumberger Christoph , Hirsch Hadorn Gertrude , Bresch David N. , Knutti Reto 
Published: June 2020

AbstractIn climate science, observational gridded climate datasets that are based on in situ measurements serve as evidence for scientific claims and they are used to both calibrate and evaluate models. However, datasets only represent selected aspects of the real world, so when they are used for a specific purpose they can be a source of uncertainty. Here, we present a framework for understanding this uncertainty of observational datasets which distinguishes three general sources of uncertainty: (1) uncertainty that arises during the generation of the dataset; (2) uncertainty due to biased samples; and (3) uncertainty that arises due to the choice of abstract properties, such as resolution and metric. Based on this framework, we identify four different types of dataset ensembles—parametric, structural, resampling, and property ensembles—as tools to understand and assess uncertainties arising from the use of datasets for a specific purpose. We advocate for a more systematic generation of dataset ensembles by using these sorts of tools. Finally, we discuss the use of dataset ensembles in climate model evaluation. We argue that a more systematic understanding and assessment of dataset uncertainty is needed to allow for a more reliable uncertainty assessment in the context of model evaluation. The more systematic use of such a framework would be beneficial for both scientific reasoning and scientific policy advice based on climate datasets.This article is categorized under:Paleoclimates and Current Trends > Modern Climate Change
Estrous cyclicity and reproductive success are unaffected by translocation for the formation of new reproductive pairs in captive red wolves (Canis rufus)
Authors: Franklin Ashley D. , Waddell William T. , Behrns Sue , Goodrowe Karen L. 
Published: June 2020

AbstractThis study investigated possible female‐related causes for inconsistent success among reproductive pairs in the zoo‐based red wolf (Canis rufus) population. Females (n = 13) at seven institutions were assessed for evidence of ovulation and normal reproductive cycles through the measurement of estradiol and progesterone metabolite excretion in feces. Fecal cortisol metabolites (FCM) were also measured. Factors potentially affecting FCM and/or estrous cyclicity were recorded, including exhibit status (on vs. off), reproductive history (proven vs. unproven), copulatory behaviors (ties observed: yes or no), pregnancy/parturition (pups or no pups produced), and translocation before the observed breeding season (yes or no). No differences were observed in baseline FCM between females housed on versus off‐exhibit (p = .46) or between females producing pups and those who did not (p = .19). Baseline FCM were significantly lower among females observed in copulatory ties compared to females never observed in a tie (p = .04), and tended to be higher in females translocated before the breeding season compared to females in existing reproductive pairs (p = .11), and among historically unproven females compared to proven females (p = .11). All females evaluated had an endocrine profile indicative of ovulation and among the four females translocated to be paired with a new male before the breeding season, two had successful pregnancies, producing litters. Therefore, despite observed differences in baseline FCM among factors, estrous cyclicity and reproductive success are unaffected by translocation for the formation of new reproductive pairs in the zoo‐based red wolf population.
Predator personality and prey detection: inter-individual variation in responses to cryptic and conspicuous prey
Authors: Szopa-Comley Andrew W. , Donald William Gregory , Ioannou Christos C. 
Published: June 2020

AbstractLimited attention constrains predators from engaging in cognitively demanding tasks such as searching for cryptic prey at the same time as remaining vigilant towards threats. Since finite attention can result in negative correlations between foraging and vigilance, the tendency of individual predators to focus attention on searching for cryptic prey may be correlated with other behavioural traits which reflect risk-reward trade-offs, such as consistent inter-individual variation in boldness (a personality trait describing risk-taking, defined in this study as the time taken to leave a refuge). We investigated the importance of personality in prey detection by comparing inter-individual variation in the response of three-spined sticklebacks (Gasterosteus aculeatus) to conspicuous and cryptic prey. Fish were slower to attack cryptic prey than conspicuous prey, consistent with cryptic prey being harder to detect. Despite the greater challenge involved in detecting cryptic prey, inter-individual variation in the time taken to detect prey was similar in the cryptic and conspicuous prey treatments, and was uncorrelated with boldness, which was repeatable between individuals. We also observed a positive association between the rate of attack on conspicuous prey and whether individual fish attacked cryptic prey in other trials. Our findings suggest that boldness is not related to prey detection or attention in this context. Instead, consistent differences in motivation once exploration has begun between individual predators may explain inter-individual variation in the time taken to attack both prey cryptic and conspicuous prey.Significance statementUsing an experimental approach to manipulate the conspicuousness of prey, we show that individual fish consistently differ in their rates of attacking prey. This demonstrates that fish show “personality variation” in predatory behaviour, but these inter-individual differences were not related to the boldness of each fish (their tendency to engage in risky behaviours).
A Numerical Study on Thermal Elastohydrodynamic Lubrication of Coated Polymers
Authors: Ziegltrum A. , Maier E. , Lohner T. , Stahl K. 
Published: June 2020

AbstractThe application of polymers in power-transmitting machine elements, e.g., gears, is limited by moderate thermo-mechanical properties and the detrimental accumulation of contact heat, even with external lubrication. Hence, polymer rolling–sliding elements are often prone to thermo-mechanical overload or abrasive wear. Diamond-like carbon (DLC) coatings are well known from steel applications for enhancing wear resistance and reducing friction. Since preliminary results indicate promising results for such coatings for polymers as well, their influence on the behavior of lubricated polymer contacts is investigated by numerical simulation. For polymer–steel contacts, the mechanical and thermophysical properties of coating and polymer are varied. The contact geometry is dominated by a local conformity, in which most of the deformation is related to the polymer. The DLC coatings affect film thickness and hydrodynamic pressure only little even for untypical high coating thicknesses. In contrast, the contact temperature decreases already for very thin coatings due to enhanced heat removal. Hence, DLC coatings can act as a thermal barrier protecting the polymer from detrimental heat and protecting the polymer from abrasive wear.
Biomass Production of Prairie Cordgrass (Spartina pectinata Link.) Using Urea and Kura Clover (Trifolium ambiguum Bieb.) as a Source of Nitrogen
Authors: Kim SungUn , Albrecht Kenneth , Sheaffer Craig , Lee Dokyoung , Subramanian Senthil , Owens Vance 
Published: June 2020

AbstractOptimizing nitrogen (N) management is an important factor for sustainable perennial biomass systems. However, N application is costly, both financially and environmentally. Our objectives were to determine: (1) N rate and plant spacing effects on yield and yield components of prairie cordgrass swards and (2) fertilizer N replacement value (FNRV) of kura clover in prairie cordgrass-kura clover binary mixtures. Plots were established in Illinois, Minnesota, South Dakota, and Wisconsin, USA, in 2010. Kura clover was transplanted on 30-cm centers in all treatments in which it was a component; prairie cordgrass seedlings were transplanted within the kura clover on 60- and 90-cm centers. Monoculture prairie cordgrass stands were established at the same population densities of mixed stands and fertilized with 0, 75, 150, or 225 kg N ha-1. Biomass was harvested in the autumn from 2011 to 2013. N (urea), year, plant spacing, and year × plant spacing affected prairie cordgrass production at all locations. Prairie cordgrass yield increased with N application, but the response varied by location. N application tended to increase prairie cordgrass tiller density and consistently increased tiller mass. Prairie cordgrass yield with 0 N was equal to or less than the yield of prairie cordgrass/kura clover mixtures at all locations in 2011 and 2012; however, kura clover provided a FNRV of 25–82 kg N ha-1 to prairie cordgrass in 2013. Kura clover has potential to provide N to prairie cordgrass in binary mixtures of these two species and on land that may not be easily farmed due to wetness.
An Indian national survey of therapeutic drug monitoring with anti-tumor necrosis (TNF) medications in inflammatory bowel disease
Authors: Patel Rajan N. , Nigam Gaurav B. , Jatale Raj G. , Desai Devendra , Makharia Govind , Ahuja Vineet , Limdi Jimmy K. 
Published: June 2020

Abstract
Background
Evidence supports therapeutic drug monitoring (TDM) in improving efficacy and cost-effectiveness of anti-TNF therapy in inflammatory bowel disease (IBD). Data on perceptions and barriers to TDM use are limited and no data are available from India. Our objective was to assess clinicians’ attitudes and barriers to TDM use in IBD.

Methods
A 16-question survey was distributed to members of the Indian Society of Gastroenterology. Information on clinician characteristics, demographics, use and barriers towards TDM with anti-TNFs was collected. Logistic regression was used to predict factors influencing TDM use.

Results
Two hundred and forty-two respondents participated (92.5% male); 83% were consultant gastroenterologists. Of 104 respondents meeting inclusion criteria (treating > 5 IBD patients and at least 1 with an anti-TNF per month), complete responses were available for 101 participants. TDM was utilized by 20% (n = 20) of respondents. Of them, 89.5% (n = 17) used TDM for secondary loss of response; 73.7% (n = 14) for primary non-response and 5.3% (n = 1) proactively. Barriers to TDM use were cost (71.2%), availability (67.8%), time lag in results (58.7%) and the perception that TDM is time-consuming (45.7%). Clinicians treating > 30 IBD patients were more likely to check TDM (OR = 4.9, p = 0.02). Of 81 respondents not using TDM, 97.5% (n = 79) would do so if all the barriers were removed.

Conclusion
Significant barriers to TDM use were availability, cost and time lag for results. If these barriers were removed, almost all the clinicians would use TDM at least reactively and 25% would use proactively. There is an urgent need to address these barriers and optimize anti-TNF therapy for optimal outcomes.
Technologies of Trauma: Flesh Witnessing to Livestreaming Online
Authors: Ibrahim Yasmin 
Published: June 2020

AbstractThis paper examines the trajectory of witnessing and testimony through modernity, utilizing the notion of ‘technologies of trauma’. Such a notion acknowledges humanity’s reliance on technologies to transmute history, trauma, or memory, transforming technologies from medium and machine into artefacts for circulation and exchange. The transcendence of medium into artefacts as sites of trauma equally highlights the socio-political frames within which testimony is extracted and witnessing is enacted, unleashing trauma as a cultural form and a resonant genre of popular consumption. This paper, in tracing the trajectory of these technologies of trauma and its cultural turn from the sensorial to mass witnessing to the aesthetic regimes of immediacy in the digital age, comes to term with our machinic bind in releasing trauma and its aestheticization as a cultural artefact and the unethical challenges, which unfold in such a proposition. The development of print, photography, television, and digital platforms as technologies of trauma reiterates the popularization of trauma, witnessing and testimony as cultural forms reiterating how these are intimately implicated in our emergence as active consuming communities of trauma and in tandem how these remake us as vulnerable subjects through the circulation of trauma as a cultural form.
Torn between Legal Claiming and Privatized Remedy: Rights Mobilization against Gold Mining in Chile
Authors: Maher Rajiv , Monciardini David , Böhm Steffen 
Published: June 2020

ABSTRACTMany academic authors, policy makers, NGOs, and corporations have focused on top-down human rights global norm-making, such as the United Nations Guiding Principles for Business and Human Rights (UNGPs). What is often missing are contextual and substantive analyses that interrogate rights mobilization and linkages between voluntary transnational rules and domestic governance. Deploying a socio-legal approach and using a combination of longitudinal field and archival data, this article investigates how a local, indigenous community in Northern Chile mobilized their rights over a period of almost two decades. We found that rights mobilization was largely shaped by tensions between the different logics of legality and the business organization. In our case, the UNGP implementation process has been ineffective in giving rightsholders access to genuine remedy. On the contrary, it has led to weakened rights mobilization, dividing the local community. We conclude that greater attention to rights mobilization and domestic governance dynamics should be given in the business and human rights debate.
Safety of ACE-I and ARB medications in COVID-19: A retrospective cohort study of inpatients and outpatients in California
Authors: Rubin Samuel J. S. , Falkson Samuel R. , Degner Nicholas R. , Blish Catherine A. 
Published: June 2020

Abstract

Introduction:
There is significant interest in the use of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) in coronavirus disease 2019 (COVID-19) and concern over potential adverse effects since these medications upregulate the severe acute respiratory syndrome coronavirus 2 host cell entry receptor ACE2. Recent studies on ACE-I and ARB in COVID-19 were limited by excluding outpatients, excluding patients by age, analyzing ACE-I and ARB together, imputing missing data, and/or diagnosing COVID-19 by chest computed tomography without definitive reverse transcription polymerase chain reaction (RT-PCR), all of which are addressed here.

Methods:
We performed a retrospective cohort study of 1023 COVID-19 patients diagnosed by RT-PCR at Stanford Hospital through April 8, 2020 with a minimum follow-up time of 14 days to investigate the association between ACE-I or ARB use with outcomes.

Results:
Use of ACE-I or ARB medications was not associated with increased risk of hospitalization, intensive care unit admission, or death. Compared to patients with charted past medical history, there was a lower risk of hospitalization for patients on ACE-I (odds ratio (OR) 0.43; 95% confidence interval (CI) 0.19–0.97; P = 0.0426) and ARB (OR 0.39; 95% CI 0.17–0.90; P = 0.0270). Compared to patients with hypertension not on ACE-I or ARB, patients on ARB medications had a lower risk of hospitalization (OR 0.09; 95% CI 0.01–0.88; P = 0.0381).

Conclusions:
These findings suggest that the use of ACE-I and ARB is not associated with adverse outcomes and may be associated with improved outcomes in COVID-19, which is immediately relevant to care of the many patients on these medications.
Employers as Subjects of the Immigration State: How the State Foments Employment Insecurity for Temporary Immigrant Workers
Authors: Gleeson Shannon , Griffith Kati L. 
Published: June 2020

AbstractThe state plays a key role in shaping worker precarity, and employers are key actors in mediating this process. While employers sometimes may act as willing extensions of the deportation machinery, they are also subjects of the immigration state. In this article, we highlight the impact of state-employer dynamics on migrant workers with Temporary Protected Status (TPS). These workers have only provisional permission to live and work in the United States, but are not tied to any single employer. Even though they are privileged over unauthorized workers and employer-sponsored guest workers, TPS holders experience their own brand of state-induced precarity. Their employers risk civil or criminal liability if they are not in compliance with work authorization requirements and must repeatedly navigate an unpredictable and confusing immigration bureaucracy. Drawing on interviews with 121 low-wage TPS workers and two dozen of their advocates in the New York City metropolitan area, our findings reveal that the intertwined coercive and bureaucratic arms of the immigration state together make hiring TPS workers a more risky and costly proposition for employers, thereby exacerbating the job insecurity that TPS workers already face due to an at-will employment regime that offers few protections against firing.
Measuring directed triadic closure with closure coefficients
Authors: Yin Hao , Benson Austin R. , Ugander Johan 
Published: June 2020

AbstractRecent work studying triadic closure in undirected graphs has drawn attention to the distinction between measures that focus on the “center” node of a wedge (i.e., length-2 path) versus measures that focus on the “initiator,” a distinction with considerable consequences. Existing measures in directed graphs, meanwhile, have all been center-focused. In this work, we propose a family of eightdirected closure coefficientsthat measure the frequency of triadic closure in directed graphs from the perspective of the node initiating closure. The eight coefficients correspond to different labeled wedges, where the initiator and center nodes are labeled, and we observe dramatic empirical variation in these coefficients on real-world networks, even in cases when the induced directed triangles are isomorphic. To understand this phenomenon, we examine the theoretical behavior of our closure coefficients under a directed configuration model. Our analysis illustrates an underlying connection between the closure coefficients and moments of the joint in- and out-degree distributions of the network, offering an explanation of the observed asymmetries. We also use our directed closure coefficients as predictors in two machine learning tasks. We find interpretable models with AUC scores above 0.92 in class-balanced binary prediction, substantially outperforming models that use traditional center-focused measures.
Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study
Authors: Zheng Jiali , Hoffman Kristi L. , Chen Jiun-Sheng , Shivappa Nitin , Sood Akhil , Browman Gladys J. , Dirba Danika D. , Hanash Samir , Wei Peng , Hebert James R. , Petrosino Joseph F. , Schembre Susan M. , Daniel Carrie R. 
Published: June 2020

AbstractDiet has direct and indirect effects on health through inflammation and the gut microbiome. We investigated total dietary inflammatory potential via the literature-derived index (Dietary Inflammatory Index (DII®)) with gut microbiota diversity, composition and function. In cancer-free patient volunteers initially approached at colonoscopy and healthy volunteers recruited from the medical centre community, we assessed 16S ribosomal DNA in all subjects who provided dietary assessments and stool samples (n 101) and the gut metagenome in a subset of patients with residual fasting blood samples (n 34). Associations of energy-adjusted DII scores with microbial diversity and composition were examined using linear regression, permutational multivariate ANOVA and linear discriminant analysis. Spearman correlation was used to evaluate associations of species and pathways with DII and circulating inflammatory markers. Across DII levels, α- and β-diversity did not significantly differ; however, Ruminococcus torques, Eubacterium nodatum, Acidaminococcus intestini and Clostridium leptum were more abundant in the most pro-inflammatory diet group, while Akkermansia muciniphila was enriched in the most anti-inflammatory diet group. With adjustment for age and BMI, R. torques, E. nodatum and A. intestini remained significantly associated with a more pro-inflammatory diet. In the metagenomic and fasting blood subset, A. intestini was correlated with circulating plasminogen activator inhibitor-1, a pro-inflammatory marker (rho = 0·40), but no associations remained significant upon correction for multiple testing. An index reflecting overall inflammatory potential of the diet was associated with specific microbes, but not overall diversity of the gut microbiome in our study. Findings from this preliminary study warrant further research in larger samples and prospective cohorts.
Dietary methionine supplementation improves the European seabass (Dicentrarchus labrax) immune status following long-term feeding on fishmeal-free diets
Authors: Machado Marina , Engrola Sofia , Colen Rita , Conceição Luis E. C. , Dias Jorge , Costas Benjamín 
Published: June 2020

AbstractMethionine is a limiting amino acid (AA) in fish diets, particularly in those containing high levels of plant protein (PP), and is key in the immune system. Accordingly, outcome on the fish immune mechanisms of methionine-deficient and methionine-supplemented diets within the context of 0 % fishmeal formulation, after a short and prolonged feeding period, was studied in European seabass (Dicentrarchus labrax). For this, seabass juveniles were fed a (i) fishmeal-free diet, meeting AA requirements, but deficient in methionine (MET0·65); (ii) as control, the MET0·65 supplemented withl-methionine at 0·22 % of feed weight (CTRL); (iii) two diets, identical to MET0·65 but supplemented at 0·63 and 0·88 % of feed weight ofl-methionine (MET1·25 and MET1·5, respectively); and (iv) a fishmeal-based diet (FM), as positive control. After 2 and 12 weeks of feeding, blood and plasma were sampled for leucocyte counting and humoral parameter assays and head-kidney collected for gene expression. After 2 weeks of feeding, a fishmeal-free diet supplemented with methionine led to changes in the expression of methionine- and leucocyte-related genes. A methionine immune-enhancer role was more evident after 12 weeks with an increased neutrophil percentage and a decreased expression of apoptotic genes, possibly indicating an enhancement of fish immunity by methionine dietary supplementation. Furthermore, even though CTRL and FM present similar methionine content, CTRL presented a reduced expression of several immune-related genes indicating that in a practical PP-based diet scenario, the requirement level of methionine for an optimal immune status could be higher.