bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pusat Sumber Belajar Matematika Berbasis Website Untuk Meningkatkan Mutu Proses Pembelajaran Matematika
Authors: Junaidi Junaidi , Yulis Tyaningsih Ratna , Sripatmi Sripatmi 
Published: December 2024

Limited access to printed materials, lack of interaction, and lack of multimedia-based learning media are significant problems, especially in remote areas such as NTB. In addition, the situation is further complicated by the limitations of infrastructure, internet connections, and teachers' technological capabilities. The purpose of this study is to create a web-based Learning Resource Center (PSB) that utilizes technology to support learning and offer interactive teaching materials. Needs analysis, PSB structure development, guideline preparation, and validation and usability test are all methods used to conduct this study. The inability of technology, the limitations of infrastructure, and the effects of print media on the environment are the main problems identified. Interactive teaching materials, teacher training, wider access to learning materials, and web-based multimedia are some of the solutions that come to mind. The results show that the web-based PSB can function as a learning resource center and support the development of technology-based teaching materials, learning systems, and multimedia. This PSB also provides facilities such as multimedia labs, digital libraries, and access to interactive teaching materials, which improve the quality of learning. So, web-based PSBs help support technology learning, overcome limited access to teaching materials, and improve the quality and efficiency of education, especially in areas with limited infrastructure.
Evaluation of a nurse practitioner-led post-discharge transitional care program for patients with liver disease: A retrospective cohort study
Authors: Naghshbandi Marjan , Huang Simon Y , Shah Hemant , Yim Colina , Lee Elizabeth , Caesar Michael , Hope Andrew , Chan Timothy CY , Sarhangian Vahid 
Published: December 2024

Background: We evaluated an outpatient, nurse practitioner-led transitional care program with respect to its efficacy in reducing unplanned readmission rates for patients with liver disease. Methods: We conducted a retrospective cohort study using data from an academic health system in Toronto, Ontario. The study included all admissions associated with an ICD10 code of R18 (ascites), I85.0 or I98.3 (variceal bleeding), or K70–K77 (diseases of the liver). Patients were selected to receive the transitional care (intervention group) or not (no-intervention group) by discretion of the hepatologists. We used a proportional hazard model to estimate the associations between receiving the intervention and the marginal probability of 30-, 60-, and 90-day readmission in the presence of death as a competing risk. We conducted sensitivity analyses to examine the robustness of our estimates to various sources of bias, including adjusting for propensity of receiving the intervention estimated using a logistic regression model. Results: A total of 803 admissions were included. Receiving transitional care was associated with a reduction in risk of 30-day readmission (HR 0.51; 95% CI 0.30–0.85), 60-day readmission (HR 0.60; 95% CI 0.40–0.91), and 90-day readmission (HR 0.55; 95% CI 0.37–0.83). The negative associations remained statistically significant under the sensitivity analyses, except for the propensity-adjusted estimate for the 60-day outcome. Conclusions: A nurse practitioner-led transitional care program could be effective in reducing the risk of readmission for patients with liver disease. Future studies are needed to standardize the referral process and prospectively measure the effectiveness and financial value of the program.
Potentially preventable? A case of recurrent blastomycosis involving the central nervous system
Authors: Walkty Andrew , Wuerz Terence , Stein Markus , Beiko Jason , Embil John 
Published: December 2024

Background: Blastomycosis is a disease caused by infection with thermally dimorphic fungi belonging to the genus Blastomyces. Central nervous system (CNS) involvement occurs in an estimated 1% to 10% of patients with blastomycosis, and treatment requires at least 12 months of antifungal therapy. Methods: We describe a 32-year-old male who presented with recurrent blastomycosis involving the CNS. Results: The patient was initially diagnosed with pulmonary blastomycosis with possible involvement of the CNS approximately 1 year prior to his current presentation. At that time, he was treated with amphotericin B deoxycholate and then subsequently transitioned to oral voriconazole. On discharge he only filled his voriconazole prescription for 8 weeks out of a planned year-long treatment course, due to an inability to afford it. He subsequently re-presented with symptoms of headache, nausea, and ataxia, and was found to have a right-sided cerebellar abscess. The abscess was drained and Blastomyces sp was isolated on culture. Following surgery, the patient was once again started on voriconazole after completing a course of liposomal amphotericin B. Social work was engaged early on during this admission. Fortunately, the patient's financial situation had improved and medication cost was no longer a barrier. When seen in follow-up, he remained on oral therapy and was doing well. Conclusions: A case of recurrent blastomycosis with involvement of the CNS is presented, where treatment failure occurred due to an inability of the patient to afford the required medication. Medication cost should always be considered and discussed with a patient when developing a treatment plan.
Does a Simulated Patient Experience Improve Physiotherapy Students’ Confidence of Shared Decision-Making? A Mixed Methods Study
Authors: Liddle Nathan , Franklin Alice , Chesterton Paul 
Published: December 2024

Background: Physiotherapy entry-level programs are designed to equip graduates with the skills required to be autonomous practitioners. Innovative teaching methods, such as role-play simulation, are designed to support students' transition into practice. This study aimed to investigate whether a simulated patient experience could influence student confidence when facilitating behavioural change using a shared decision-making approach. Method: A mixed methods design comprising online pre- and post-surveys of student physiotherapists at one UK higher education institution, followed by an invitation to participate in a follow-up semi-structured focus group. Pre- and post-simulation surveys were completed in addition to the Modified Satisfaction with Simulation Experience (MSSE) survey. Likert scale data were treated as numeric variables with the median and Interquartile (IQR) range calculated for combined responses across potential answers. Focus groups included semi-structured questions with thematic analysis generating themes. Results: All 39 respondents “Strongly Agreed” that they were satisfied with the simulated experience, which could be transferred to clinical practice (5, IQR 4–5). The stimulation developed both confidence (5, IQR 4–5) and developed participants’ perception of their shared decision-making skills (4, IQR 4–5). Three key emergent themes from the focus groups included (1) Bridging the gap between clinical practice, (2) Authenticity, and (3) Psychological safety. Conclusion: The simulated role-play patient experience improved the confidence and participants’ perception of their ability to use shared decision-making to facilitate behavioural change. Themes from the semi-structured interviews suggested increased authenticity and psychological safety during the task, which could bridge the gap between theoretical teaching and clinical practice.
МЫРЫШ-ФОСФАТТЫ ЦЕМЕНТІ АГРЕССИВТІ ОРТАНЫҢ ӘСЕРІНЕН ХИМИЯЛЫҚ ТӨЗІМДІЛІГІН ЗЕРТТЕУ
Authors: Абдуллин А. , Жаникулов Н. , Таймасов Б. , Потапова Е. 
Published: December 2024

Ғылыми мақалада синтезделген мырыш-фосфатты цементті агрессивті ортаның әсерінен химиялық төзімділігін зерттеу бойынша нәтижелер келтірілген. 1000 °С температурада 4 сағат күйдіріліп алынған мырыш-фосфатты цементтің құрамы: ZnO - 83,0 %, MgO - 9,0 %, SiO2 - 3,5 %, Bi2O3 - 3,0 %, фосфор шлагы - 1,5 % тұрады. МФЦті шарлы диірменде ұнтақтаудан кейінгі үлестік беті 3345 см2/г тең болды. Үлгілерді формаға қалыптау үшін дайындалған қоспада цемент/ерітінді қатынасы Ц/Е=0,3 алынды. Ұстасу мерзімінің басталуы 6 мин, ал аяқталуы 9 мин құрады. Мырыш-фосфатты цемент үлгілерді агрессивті ортаның әсерінен химиялық төзімділігін анықтау үшін беріктік шегі тексерілді. Нәтижесінде 10 % сүт қышқылында – 98,8 МПа, 5 % NaCl ерітіндісінде – 100,1 МПа және газдалған суда – 104,4 МПа болды. Рентгенофазалық талдау нәтижесінде мырыш-фосфатты цемент құрамында цинцит (ZnO) минералы - 52,3 %, периклаз (MgO) минералы - 32,9 % және кварц (SiO2) минералы - 14,8 % мөлшерінде анықталды. Электронды микроскопиялық талдау нәтижесінде мырыш-фосфатты цемент құрамында: ZnО – 87,06 %, CaО – 0,57 %, SiО2 – 4,36 %, Al2О3 – 0,64 %, MgО – 7,37 % анықталды. Осылайша, мырыш-фосфатты цемент беріктігіне агрессивті орта 10 % сүт қышқылы – 8,0 %, 5 % NaCl – 6,8 % және газдалған су – 2,8 % төмендетті. Сондай-ақ, мырыш-фосфатты цементтің минералогиялық құрамында, оның суды сіңіруі, шөгу процесінде өзгерістердің болмағандығын көрсетті. Микроқұрылымдық талдау нәтижесінде мырыш-фосфатты цемент құрамында аморфты фаза анықталды. Фаза ортофосфор қышқылымен реакцияға түспеген аморфты фосфат матрицасындағы мырыш оксидінің (ZnO) артық бөлшектерінен тұрады. МФЦ микроқұрылымды кристалдардың кең кеуектілігі анықталды, кеуектілік өлшемі 1-5 мкм құрады. Бұл зерттеуді Қазақстан Республикасы Ғылым және жоғары білім министрлігінің Ғылым коминеті қаржыландырды (грант №АР22683868 – Қазақстанның стоматологиялық қажеттіліктері үшін мырыш-фосфатты композициялық цементтің құрамын зерттеу және әзірлеу»).
Real-Time 3D Object Detection Using InnovizOne LiDAR and Low-Power Hailo-8 AI Accelerator
Authors: Krispin-Avraham Itay , Orfaig Roy , Bobrovsky Ben-Zion 
Published: December 2024

Object detection is a significant field in autonomous driving. Popular sensors for this task include cameras and LiDAR sensors. LiDAR sensors offer several advantages, such as insensitivity to light changes, like in a dark setting (Figure 2) and the ability to provide 3D information in the form of point clouds, which include the ranges of objects. However, 3D detection methods, such as PointPillars[1], typically require high-power hardware. Additionally, most common spinning LiDARs are sparse and may not achieve the desired quality of object detection in front of the car. In this paper, we present the feasibility of performing real-time 3D object detection of cars using 3D point clouds from a LiDAR sensor, processed and deployed on a low-power Hailo-8 AI accelerator[2]. The LiDAR sensor used in this study is theInnovizOne sensor[3], which captures objects in higher quality compared to spinning LiDAR techniques, especially for distant objects. We successfully achieved real-time inference at a rate of approximately 5Hz with a high accuracy of 0.91% F1 score, with only -0.2% degradation compared to running the same model on an NVIDIA GeForce RTX 2080 Ti[4]. This work demonstrates that effective real-time 3D object detection can be achieved on low-cost, low-power hardware, representing a significant step towards more accessible autonomous driving technologies. The source code and the pre-trained models are available at https://github.com/AIROTAU/PointPillarsHailoInnoviz/tree/main.
The Oxford Guide to the Uralic Languages
Authors: Kaheinen Kaisla , Erkkilä Riku , Qiu Toivo 
Published: December 2024

Besprechung
Bakró-Nagy, Marianne & Laakso, Johanna & Skribnik, Elena (eds․). 2022. The Oxford Guide to the Uralic Languages. Oxford University Press. LV + 1115 pp.
A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer
Authors: Wang Shuo , Hou Sen , Jiang Shan , Wang Chao , Zhang Peipei , Ye Yingjiang , Gao Zhidong 
Published: December 2024

BackgroundAn increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the prognosis, as well as the tumor immune microenvironment, in individuals with colon cancer remains poorly understood.MethodsWe conducted a comprehensive evaluation of the LLPS cluster in 1010 colon cancer samples from the TCGA and GEO databases, utilizing the expression profiles of LLPS-related prognostic differentially expressed genes (DEGs). Subsequently, a LLPS-related gene signature was constructed to calculate the LLPS-related risk score (LRRS) for each individual patient.ResultsTwo LLPS subtypes were identified. Substantial variations were observed between the two LLPS subtypes in terms of prognosis, pathway activity, clinicopathological characteristics, and immune characteristics. Patients with high LRRS exhibited worse prognosis and poorer response to immunotherapy. LRRS was found to be correlated with the clinicopathological characteristics, genomic alterations, and the potential response to immune checkpoint inhibitors therapy of colon cancer patients. Additionally, the biological function of a key gene POU4F1 was verified in vitro.ConclusionsThis study highlights the crucial role of LLPS in colon cancer, LRRS can be used to predict the prognosis of colon cancer patients and aid in the identification of more effective immunotherapy strategies.
Imaging biomarker associated with early neurological deterioration in isolated pontine infarction
Authors: Song Xiaowei , He Feifei , Hou Duoduo , Zhao Hongliang , Wei Chenming , Chen Le , Pengmao Zhuoma , Wu Jian 
Published: December 2024

ObjectiveTo investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.Methods107 patients with acute isolated pontine infarcts, within 24 h of symptom onset, were retrospectively analyzed. The mean age of the participants was 67 years. The burden of cerebral small vessel disease on brain MRI was assessed, including white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMB), and enlarged perivascular spaces (EPVS) for each patient. Additionally, other imaging biomarkers including basilar artery plaque features on high-resolution MR vessel wall imaging and intracranial artery stenosis were evaluated simutaneously. END was defined as an increase of ≥1 point on the motor component of the National Institutes of Health Stroke Scale (NIHSS) or an increase of ≥2 points on the total NIHSS score within 72 h of admission. Statistical analyses were performed using t-tests, chi-square tests, and logistic regression.Results33.6% (36/107) of the patients experienced END. The END group exhibited a higher prevalence of hyperlipidemia compared to the non-END group (66.7% vs. 43.7%, p = 0.024). Over 50% of the mechanisms of infarction can be attributed to basilar artery branch disease in both groups, with 58.3% in the END group and 50.7% in the non-END group. In a multivariate regression analysis, neither the total burden of cerebral small vessel disease nor the presence of WMH, CMB, lacunes, or EPVS were significantly associated with END (all p &gt; 0.05). However, basilar artery intraplaque hemorrhage observed on vessel wall imaging was independently associated with END (OR = 3.233, 95% CI 1.032–10.123, p = 0.044).ConclusionNo association was found between the imaging features of cerebral small vessel disease and END in patients with isolated pontine infarction. However, basilar artery intraplaque hemorrhage serve as an independent predictor of END in this population.
Effectiveness and safety of echinocandins combination therapy with the standard of care compared to the standard of care monotherapy for the treatment of invasive aspergillosis infection: a meta-analysis
Authors: Alsowaida Yazed Saleh , Alshoumr Bader , Alowais Shuroug A. , Bin Saleh Khalid , Alshammari Alia , Alshurtan Kareemah , Wali Haytham A. 
Published: December 2024

BackgroundThis meta-analysis aims to evaluate the effectiveness and safety of combining echinocandins with standard of care (SOC) antifungal drugs for treating invasive aspergillosis infection (IAI).MethodWe searched PubMed, Embase, and Cochrane Library from their inception to 25 July 2024. Our outcomes included clinical cure, mortality, and adverse drug reactions (ADRs). We compared echinocandins in combination with SOC antifungal agents against SOC monotherapy therapy. We used the random-effects model for the meta-analysis, and our estimated effects were reported as odds ratios (ORs) with 95% confidence intervals (CI).ResultsTen studies were included in our meta-analysis comprising 1100 patients: 415 were in the echinocandin combination groups, and 685 were in the SOC groups. The clinical cure rate (OR 1.35, 95% CI: 0.75–2.42, p = 0.27), mortality (OR 0.90, 95% CI: 0.50–1.63, p = 0.73), and ADRs rate (OR 0.95, 95% CI: 0.49–1.82, p = 0.87) were not statistically different in echinocandins combination with SOC compared to SOC monotherapy. Notably, there is a signal for a better clinical cure rate in echinocandins in combination with SOC.ConclusionOur meta-analysis found no differences in clinical cure and mortality rate when using combination therapy of echinocandin antifungal agents with the SOC compared to SOC monotherapy. However, there is a signal for better outcomes with the echinocandins combination group. The ADRs in the echinocandins combination group were not worse than SOC monotherapy.
Exploring the potential of electrical bioimpedance technique for analyzing physical activity
Authors: Hafid Abdelakram , Zolfaghari Samaneh , Kristoffersson Annica , Folke Mia 
Published: December 2024

IntroductionExercise physiology investigates the complex and multifaceted human body responses to physical activity (PA). The integration of electrical bioimpedance (EBI) has emerged as a valuable tool for deepening our understanding of muscle activity during exercise.MethodIn this study, we investigate the potential of using the EBI technique for human motion recognition. We analyze EBI signals from the quadriceps muscle and extensor digitorum longus muscle acquired when healthy participants in the range 20–30 years of age performed four lower body PAs, namely squats, lunges, balance walk, and short jumps.ResultsThe characteristics of EBI signals are promising for analyzing PAs. Each evaluated PA exhibited unique EBI signal characteristics.DiscussionThe variability in how PAs are executed leads to variations in the EBI signal characteristics, which, in turn, can provide insights into individual differences in how a person executes a specific PA.
Satiety-enhancing placebo intervention decreases selective attention to food cues
Authors: Lanz Marina , Hoffmann Verena , Meissner Karin 
Published: December 2024

BackgroundAs placebo interventions could influence appetite and satiety in first studies, they are a promising tool for the future treatment of obesity. Furthermore, individuals with heightened body weight show increased selective attention for food cues. This study aimed to investigate whether placebo induced changes of appetite and satiety can affect attention allocation and to examine correlating factors.MethodsIn a double-blind design, 63 healthy participants were randomized into one of three groups: the enhanced appetite placebo group, the enhanced satiety placebo group, or the control group. Appetite and satiety were induced by administering a placebo capsule along with a group specific expectancy manipulation. One hour later, participants performed a visual probe task to measure attentional bias by comparing reaction times for different conditions. Correlations between reaction times and subjective hunger and satiety ratings, as well as current food craving and plasma ghrelin levels, were explored.ResultsThe induction of attentional bias toward non-food stimuli was successful in women in the enhanced satiety placebo group but not in the enhanced appetite placebo group. Women of the enhanced satiety placebo group showed significantly higher reaction times for food cues compared to non-food cues. Across conditions, reaction times were associated with subjective hunger ratings and current food craving in women. No attentional bias was induced in men in either placebo group.ConclusionPlacebo-induced satiety inhibited attention allocation toward food in healthy women, potentially mediated by reduced hunger and food craving. Placebo effects on satiety could thus be demonstrated on a highly complex cognitive process.
Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease
Authors: Chen Chien-Hui , Hsu Wei-Li , Tsai Pei-Shiue Jason , Lai Chun-Fu , Wu Meng-Ting , Lee Ya-Jane 
Published: December 2024

IntroductionHypoxia-inducible factors (HIF) regulate gene transcription, which aids hypoxia adaptation while promoting renal fibrosis. Non-transferrin-bound iron (NTBI) is a catalytic form of iron that can lead to oxidative damage. However, NTBI in cat biofluids has rarely been evaluated.AimsWe assessed cat plasma and urine HIF-1α (pHIF-1α/uHIF-1α) concentrations and urine NTBI (uNTBI) concentrations to investigate their relationship with chronic kidney disease (CKD) severity.MethodspHIF-1α and uHIF-1α concentrations were measured using commercial ELISA kits, while uNTBI concentrations were detected by inductively coupled plasma mass spectrometry.ResultsHealthy cats (n = 35) and cats with CKD (n = 84) formed the study cohorts. pHIF-1α concentrations increased from 9.48 pg./mL (median) in the healthy cohort to 11.42 pg./mL in early-stage CKD cats but decreased to 8.50 pg./mL in late-stage CKD cats. uHIF-1α concentrations gradually decreased with a significant difference between the control group (44.61 pg./mL) and the late-stage CKD group (36.79 pg./mL, p &lt; 0.001). Cats with proteinuria had significantly higher uNTBI concentrations (35.61 ppb) than non-proteinuric cats (25.13 ppb, p = 0.019). Finally, the concentrations of pHIF-1α and uHIF-1α were positively correlated independent of renal function.Conclusion and clinical importanceOverall, pHIF-1α and uHIF-1α concentrations are lower in advanced CKD cats, while uNTBI concentrations are significantly higher in proteinuric cats.