bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p
Authors: Zhang Chunyan , Lian Hongkai , Xie Linsen , Yin Ningwei , Cui Yuanbo 
Published: March 2020

AbstractAccumulating studies highlight the critical role of long non-coding RNAs (lncRNAs) in the development of various human cancers. Extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense RNA 1 (ELFN1-AS1) was shown to be a newly found lncRNA that abnormally expressed in human tumors. However, till now the specific function of this lncRNA in esophageal cancer (ESCA) remains unknown. In this study, we discovered that higher ELFN1-AS1 expression indicated shorter patient survival in pan-cancer, including ESCA, using online The Cancer Genome Atlas (TCGA) tools. The lncRNA ELFN1-AS1 was significantly up-regulated in ESCA tissues and cell lines when compared with the counterparts. Down-regulation of ELFN1-AS1 restrained cell proliferation, migration, and invasion of ESCA in vitro. In addition, we found that the expression of microRNA-183-3p (miR-183-3p) and ELFN1-AS1 or glutamine-fructose-6-phosphate transaminase 1 (GFPT1) were inversely correlated in ESCA. Both ELFN1-AS1 and GFPT1 are direct targets of miR-183-3p in ESCA. The effects of ELFN1-AS1 knockdown on ESCA progression were partially rescued by inhibition of miR-183-3p or over-expression of GFPT1. In summary, the results of this study suggest that the lncRNA ELFN1-AS1 facilitates the progression of ESCA by acting as a competing endogenous RNA (ceRNA) to promote GFPT1 expression via sponging miR-183-3p.
The MICOS complex, a structural element of mitochondria with versatile functions
Authors: Khosravi Siavash , Harner Max E. 
Published: March 2020

Abstract
Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formation of mitochondrial architecture have been identified. Here we will review the current knowledge of the MICOS complex, one of the major structural elements of mitochondria. MICOS is a multi-subunit complex present in the inner mitochondrial membrane. Multiple interaction partners in the inner and outer mitochondrial membrane point to participation in a multitude of important processes, such as generation of mitochondrial architecture, lipid metabolism, and protein import into mitochondria. Since the MICOS complex is highly conserved in form and function throughout evolution, we will highlight the importance of MICOS for mammals. We will emphasize in particular the current knowledge of the association of MICOS with severe human diseases, including Charcot–Marie–Tooth disease type 2, Alzheimer's disease, Parkinson's disease, Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Clinical profile and care pathways among unaccompanied minor asylum seekers in Vaud, Switzerland
Authors: Genton Paul Camille , Wang Jen , Bodenmann Patrick , Ambresin Anne-Emmanuelle 
Published: March 2020

Abstract

Objectives
The objectives of this study were to describe the overall clinical profile (somatic and psychological health) and the care pathways of unaccompanied minor asylum seekers (UMAS) who arrived in the Swiss canton of Vaud in 2015.

Methods
This was a retrospective study based on information extracted from the medical files of 109 patients over 1 year of follow-up. All the reasons for consultation and referrals as well as the diagnoses made were noted and coded using ICD-10. The healthcare providers for all diagnoses and referrals were also noted.

Results
Our sample was predominantly male (87.2%) and hailed primarily from Eritrea (39.4%) and Afghanistan (32.1%). Gatekeeping nurses at a specialized migrant care facility (MCF) referred 67.7% of the UMAS to other providers for further medical care, including 45.4% to the Interdisciplinary Division for Adolescent Health (DISA). However, 46.8% of the 109 UMAS also sought care at other structures without any referral by MCF or DISA as intended. Of the patients 39.4% were found to have at least one mental health problem, mainly functional disorders (21.1%), symptoms and episodes of depression (17.4%), symptoms of post-traumatic stress disorder (PTSD) (13.8%) and sleeping disorders (12.8%). The most common diagnoses of infectious diseases included community-acquired respiratory infections (43.1%), scabies (20.2%) and cases of skin abscesses and furuncles (13.8%). In fewer instances, cases of active tuberculosis (3.7%), chronic hepatitis B (2.8%), intestinal parasites (1.8%) and gastritis caused by Helicobacter pylori (1.8%) were also diagnosed. A significant proportion of UMAS presented traumatological (30.3%) and ophthalmological (25.7%) problems. Among the female UMAS (12.8% of the sample), evidence of genital mutilation (21.4%), pregnancy (21.4%) and abortion (14.3%) was common.

Conclusions
An integrated approach involving efficient coordination between different providers is necessary in order to respond adequately to the major healthcare needs of UMAS. Special attention should be paid to mental health.
Manual physical therapy as a novel treatment modality for Autism spectrum disorder – A pilot study
Authors: Jungade Shyam 
Published: March 2020

Abstract

Background
Autism spectrum disorders (ASDs) fall under neurodevelopmental disorders and are characterized by impaired social interaction and communication, restricted interests, and repetitive behaviors. The current available treatments aim at functional rehabilitation with resultant partial improvement in few and the persistent handicap in rest of them. Manual physical therapy or manual manipulation therapy has the basis in structural rehabilitation of the patient and has been proposed to act by both peripheral and central mechanisms.

Case presentation
To study improvement in different components of ASD by manual physical therapy, the therapy comprised of soft tissue therapy, in the form of myofascial release (MFR) of deep fascia of leg and foot muscles. The child with ASD, treated by manual physical therapy had global improvement in all the deficits.

Conclusions
This is probably first case of autism reported to have almost complete symptom resolution, with any single form of treatment and this form of therapy holds promise in integrative and holistic management of the patient.
Crystal structure of 3-(2-methylbenzyl)thiazolidin-2-one, C11H13ONS
Authors: Lin Qiao , Lin Zirui , Chen Xiuwen , Li Bin 
Published: March 2020

Abstract
C11H13ONS, monoclinic, P21/c (no. 14), a = 8.0795(6) Å, b = 7.2294(5) Å, c = 17.5898(14) Å, β = 98.354(8)°, V = 1016.52(13) Å3, Z = 4, R
gt(F) = 0.0332, wR
ref(F
2) = 0.0825, T = 120.00(10) K.
The crystal structure of 2,2,2-trifluoro-1-(isoquinolin-1-yl)ethane-1,1-diol, C11H8F3NO2
Authors: Yi Qin , Zhu Xiong , Zhang Ji-Run , Zhou Zhi-Xu , Zhao Chun-Shen 
Published: March 2020

Abstract
C11H8F3NO2, monoclinic, P21/c (no. 14), a = 8.6599(8) Å, b = 11.6216(12) Å, c = 10.0903(9) Å, β = 93.393(2)°, V = 1013.73(17) Å3, Z = 4, R
gt(F) = 0.0352, wR
ref(F
2) = 0.0984, T = 273(2) K.
Noise metrics analysis in schools near airports: A Brazilian case study
Authors: Taufner Mariani Dan , Gama Ana Paula , Slama Jules Ghislain , Torres Julio Cesar Boscher 
Published: March 2020

Abstract
This study compares metrics for environmental noise diagnosis in schools at airport vicinity. The goal is to analyze and identify the most suitable criteria for scaling aircraft noise impact over schools, during landing and take-off operations. A Brazilian case study is conducted, based on the noise mapping and sound level verification. The day-night average noise level (DNL) and the time above limit (TA) are investigated using acoustic simulation and noise mapping and in order to identify the critical receivers. Results of DNL and TA for two schools at airport surroundings show that the criteria adopted by the municipal and airport authorities to describe the airport noise are unsatisfactory and do not reflect the intermittent behavior of this type of noise. It was verified that individual receiver analysis, based on noise interruptions thought TA parameter is more suitable for evaluation of noise impact over schools at airport vicinity.
Abandoned agricultural soils from the central part of the Yamal region of Russia: morphology, diversity, and chemical properties
Authors: Abakumov Evgeny , Morgun Evgeniya , Pechkin Alexandr , Polyakov Vyacheslav 
Published: March 2020

AbstractThe post-anthropogenic and soil cover transformations of former agricultural soils on the abandoned lands in the Russian Arctic territory are poorly investigated due to the active growth of the city complexes and increasing area occupied by agricultural lands. That is lead to an increase in the area of the arable lands surrounding the polar urbanized territories. Today, most of that land allocated for agricultural needs has been abandoned or affected by other types of land use. This study aimed to investigate the abandoned lands surrounding some of the settlements in the central part of the Yamal region. The soil diversity, morphology, and chemical and agrochemical properties were investigated with special reference to the specific transformations that occur to fallow lands under permafrost-affected cryogenic-ecosystem conditions. Analysis of data show that these soils are characterized by features relating to both, previous (and existing), anthropogenic impacts and natural processes such as cryogenic mass transfer. The degradation of the arable humus-enriched horizon was not as pronounced as it has been in more humid boreal environments over recent decades. The organic carbon content in topsoil depends on the land use and varied considerably among the soil types. The former arable topsoil horizon has been stable over time in terms of its morphological features and agrochemical state. Despite the high soil acidity levels, thenutrient content in the anthropogenically impacted soils was still high, even though being abandoned for 20 years.
Die internationale Ordnung: Bestandsaufnahme und Ausblick
Authors: Maull Hanns W. 
Published: March 2020

Zusammenfassung
Um die Entwicklung der internationalen Ordnung zu diagnostizieren, bedarf es zunächst einer präzisen Begrifflichkeit. Dieser Beitrag versteht die Weltordnung als spezifische Ausprägung politischer Ordnung, die eng verwoben mit nationalstaatlichen politischen Ordnungen funktioniert. „Die“ internationale Ordnung als umfassende Weltordnung ist ein relativ junges Phänomen, das dennoch bereits eine differenzierte historische Entwicklung aufweist. Die gegenwärtige, seit 1990 bestehende Weltordnung erfährt – nach einer Phase der Konsolidierung und der Expansion in den 1990er Jahren – etwa seit 2003 eine sich beschleunigende Erosion. Der Beitrag beschreibt die wesentlichen Charakteristika dieser Ordnung, erläutert die Ursachen der Erosions- und Zerfallsprozesse, die inzwischen ein gefährliches Ausmaß erreicht haben, und blickt auf die sich abzeichnende zukünftige internationale Ordnung.
Doppelte Wendezeit
Authors: Spohr Kristina 
Published: March 2020

Zusammenfassung
Die Welt veränderte sich dramatisch, als die Berliner Mauer fiel und Proteste zum Massaker auf dem Platz des Himmlischen Friedens führten. Basierend auf umfangreichen Archivrecherchen zeigt der Aufsatz, wie sich der revolutionäre Umbruch von 1989 in Europa und Asien abspielte und wie in der Folge eine neue internationale Ordnung geschaffen wurde – ohne größere Konflikte. Die Welt nach dem Mauerfall wurde in erheblichem Maße durch die entschlossene Diplomatie einer kleinen Kohorte internationaler Staatslenker geschaffen, die harte, aber kooperative Verhandlungen führten, um die Institutionen des Kalten Krieges neu zu erfinden. Nicht alle Beziehungen waren einfach, wobei eine tiefgreifende historische Skepsis vor allem Deutschland gegenüber bestand. Dennoch, in Partnerschaft und durch ihre Bündnisse, wollten sie alle eine bessere Welt aufbauen – eine auf gemeinsamen Prinzipien basierende internationale Ordnung. Um der Berechenbarkeit, der Stabilität und des Friedens willen beschlossen sie, die alten westlichen Institutionen, insbesondere die EG/EU und die NATO, die den Osten integrieren würden, zu bewahren, zu modifizieren und neu zu erfinden. Die Transformation Europas muss jedoch im globalen Kontext verstanden werden. Wenn man diesen Weg der Geschichte dem in Peking gegenüberstellt, wo Deng Xiaoping die Demokratiebewegung brutal unterdrückte, lässt sich zeigen, wie Deng China nach dem Tiananmen auf eine ganz andere Bahn brachte; eine, die das Reich der Mitte durch kommunistische Neuerfindung vom insularen maoistischen Entwicklungsstaat zur autoritativ-kapitalistischen Weltmacht geführt hat. Auf diese Weise erwiesen sich die Scharnierjahre 1989–1992 nicht als das Ende der Geschichte, sondern hatten klare Auswirkungen auf unsere Zeit: die Welt von Putin, Trump und Xi.
Den Westen neu denken. Wege aus der Krise der freien Welt
Authors: Kleine-Brockhoff Thomas 
Published: March 2020

Zusammenfassung
Nachdem ein viertel Jahrhundert lang die Annahme verbreitet war, die Welt strebe dem demokratischen Frieden zu, wähnen heute viele den Rechtspopulismus auf einem nicht zu stoppenden Siegeszug. Dieses lineare Denken rechnet mit dem (Hirn)-Tod der NATO, dem Ende des Westens und dem Zerfall der liberalen internationalen Ordnung. Statt sich dem Fatalismus hinzugeben, sollten die Freunde der Freiheit den Westen neu denken, indem sie die liberale Überdehnung der vergangenen Jahre hinter sich lassen und stattdessen einen bescheidenen und zugleich robusten Liberalismus entwickeln, der die Grundlage einer erneuerten Ordnung bilden kann.
Fritz Eisels Mosaik Der Mensch bezwingt den Kosmos am Rechenzentrum in Potsdam. Eine kunsthistorische Kontextualisierung von Ort, Werk und Rezeption
Authors: König Susanne 
Published: March 2020

Abstract
The subject of this essay is Fritz Eisel’s mosaic Der Mensch bezwingt den Kosmos (Humanity Conquers the Cosmos), a frieze that has decorated the Potsdam data-processing center since its completion in 1972. Composed of 18 panels measuring ca. 3 × 3 m, this frieze is unusually large, yet in its ideological appropriation of science and technology it is a paradigmatic example of public art in the German Democratic Republic. Framed by textual references to Einstein and Marx, Eisel’s mosaic glorifies the progress of industry, agriculture, and administration, but first and foremost of aviation and space flight. This essay examines the mosaic in the context of the “scientific-technical revolution” officially proclaimed in 1964, and with a view to its site, which is fraught with historical implications.
The symmetry principle of antiaromaticity
Authors: Berger Raphael J. F. , Viel Alexandre 
Published: March 2020

Abstract
Current definitions of aromaticity are purely phenomenological and relate symmetry, reactive stability and the occurrence of molecular diamagnetic response currents. The antithetical concept of antiaromaticity provides a connection between the contrary properties: structural instability or distortion out of higher symmetry, a small HOMO-LUMO gap, and paramagnetic response currents. We reveal the symmetry principle that is underlying antiaromaticity by showing an intimate and strict symmetry induced relation between these properties. The principle is mathematically rigorous and can be formulated like: First order (and related) Jahn-Teller distorted molecules out of non-cubic and non-icosahedral point groups are prone to induced paramagnetism in magnetic fields parallel to the main axis of symmetry. We show by the exemplary cases of cyclobutadiene, cyclcooctatetraene, pentalene and manganese trifluoride how this principle works and discuss this new perspective on antiaromaticity.
Queer(ed) Pedagogies: A Critical Perspective
Authors: Bauer Gero , Engelmann Sebastian 
Published: March 2020

Abstract
Current political controversies concerning progressive concepts of sex education in schools lead to an often openly aggressive dispute about the handling of identity concepts, understandings of gender, and knowledge in school and extracurricular contexts. In addition to general emancipatory concepts which emphasise diversity and tolerance, the discussion increasingly considers queer-theoretical interventions. This article outlines the axiological questions of a queer pedagogy, and offers insights into practices which might emerge as a result of such considerations. At the same time, it formulates theoretical questions of a queer pedagogy as they pertain to a more general theory of educational processes, and which concern not only the practice of teaching and learning, but also the formation of educational theory.
Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT-3 inCaenorhabditis elegans
Authors: Mesbahi Hiva , Pho Kim B , Tench Andrea J , Leon Guerrero Victoria L , MacNeil Lesley T 
Published: March 2020

AbstractMesbahi et al. find that environmental factors, including diet, starvation, and population density can differentially influence the penetrance of collagen mutant phenotypes. Factors that decrease the penetrance of rolling in dominant...The nematode Caenorhabditis elegans is protected from the environment by the cuticle, an extracellular collagen-based matrix that encloses the animal. Over 170 cuticular collagens are predicted in the C. elegans genome, but the role of each individual collagen is unclear. Stage-specific specialization of the cuticle explains the need for some collagens; however, the large number of collagens suggests that specialization of the cuticle may also occur in response to other environmental triggers. Missense mutations in many collagen genes can disrupt cuticle morphology, producing a helically twisted body causing the animal to move in a stereotypical pattern described as rolling. We find that environmental factors, including diet, early developmental arrest, and population density can differentially influence the penetrance of rolling in these mutants. These effects are in part due to changes in collagen gene expression that are mediated by the GATA family transcription factor ELT-3. We propose a model by which ELT-3 regulates collagen gene expression in response to environmental stimuli to promote the assembly of a cuticle specialized to a given environment.
El Comité de derechos humanos y la presunción de inocencia: ¿Un derecho extraprocesal?
Authors: Hidalgo Flores Héctor Ivar 
Published: March 2020

The Human Rights Committee has issued several legal opinions wherein it has analyzed the right to the presumption of innocence. This United Nations body has unraveled the scope of this guarantee and, certainly, has brought to surface its multifaceted character. However, much of its jurisprudence has focused on the extra-procedural aspect of this right. Therefore, as the working hypothesis, it was formulated that the right to the presumption of innocence, from the interpretation of the Human Rights Committee, was a purely extra-procedural guarantee. However, the investigation showed that although its jurisprudence has been characterized by conceiving this principle as a right that comes to life outside the legal process, it also contains other criteria that extend the scope of this legal institution.
INNOVATIONS AND THEIR INDUSTRIAL CLASSIFICATIONS: APPROACH TO BUILDING A NEW TYPOLOGY
Authors: Trachuk A. V. , Linder N. V. 
Published: March 2020

The article is devoted to the analysis of research in the field of typology and classification of innovations. We consider three types of classification the second innovation: the classification by type of innovation and application; classification of innovations by degree of novelty and level of change; rating by innovation. The article proposes a fourth approach to classifying innovations as possible to manage them. The signs of controllability for classification are highlighted:• adaptability (degree to which the innovation can be changed to satisfy requirements),• applicability (level of use of innovation in multiple settings),• relatedness (connected with the main business of the innovator),• architecture (shows how much innovation should be built into the system for application (or can be used independently without rebuilding the entire system as a whole),• autonomy (to be able to use innovation regardless of other novelties),• centeredness (reflects the level to which innovations can influence operations that are critical to organizational effectiveness),• sociability (the degree to which individual aspects of innovation nations can be transferred to others to form a positive attitude towards its adoption),• compatibility (the degree to which innovation is perceived as consistent with existing values, experience and the needs of potential followers).The types and classifications of product, technological (process), marketing, organizational and managerial innovations are examined. The so-called simulative innovations are separately considered. The analysis of the innovation activity of industrial companies made it possible to single out another new type – “value” innovations, which is the main theoretical contribution of this work.
Method for Determination of Focal Mechanisms of Magnitude 2.5–4.0 Earthquakes Recorded by a Sparse Regional Seismic Network
Authors: Dahal Nawa R. , Ebel John E. 
Published: March 2020

ABSTRACTFocal mechanisms of earthquakes with magnitudes Mw 4.0 and less recorded by a sparse seismic network are usually poorly constrained due to the lack of an appropriate method applicable to finding these parameters with a sparse set of observations. We present a new method that can accurately determine focal mechanisms of earthquakes with Mw (3.70–3.04) using data from a few regional seismic stations. We filter the observed seismograms as well as synthetic seismograms through a frequency band of 1.5–2.5 Hz, which has a good signal-to-noise ratio for small earthquakes of the magnitudes with which we are working. The waveforms are processed to their envelopes to make the waveforms relatively simple for modeling. To find the optimal focal mechanism for an event, a nonlinear moment tensor inversion in addition to a coarse grid search over the possible dip, rake, and strike angles at a fixed value of focal depth and a fixed value of scalar moment is performed. We tested the method on 18 aftershocks of Mw (3.70–2.60) of the 2011 Mw 5.7 Mineral, Virginia, earthquake and on five aftershocks of Mw (3.62–2.63) of the 2013 Mw 4.5 Ladysmith, Quebec, earthquake. Our method obtains accurate focal mechanisms for 16 out of the 21 events that have previously reported focal mechanisms. Tests of our method for different crustal models show that event focal mechanism determinations vary with an average Kagan angle of 30° with the different crustal models. This means that the event focal mechanism determinations are only somewhat sensitive to the uncertainties in the crustal models tested. This study confirms that our method of modeling envelopes of seismic waveforms can be used to extract accurate focal mechanisms of earthquakes with short-time functions (Mw&lt;4.0) using at least three regional seismic network stations at epicentral distances of 60–350 km.