bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and construct validity of the modified Finnish version of the 9-item Patient Health Questionnaire, and its’ content validity within biopsychosocial frame among female healthcare workers with sub-acute or recurrent LBP
Authors: Suni Jaana Helena , Virkkunen Tarja , Husu Pauliina , Tokola Kari , Parkkari Jari , Kankaanpää Markku 
Published: December 2019

Abstract
Background: Healthcare workers have increased risk for chronic low back pain (LBP) leading to reduced workability. Depression, a highly prevalent, costly and disabling condition, is commonly seen in patients with sub-acute LBP. This study investigated the psychometric properties and content-validity of a modified 9-item Patient Health Questionnaire (PHQ-9-mFIN) in female healthcare workers with sub-acute LBP. Methods: Reliability (internal consistency, test-retest repeatability) was assessed with standard methods. Construct validity of the PHQ-9-mFIN was assessed as level of depression (PHQ-9-mFIN: 0-4 none, 5-9 mild, ≥10 at least moderate) against RAND-36 Health Survey, a valid measure of health-related quality of life (HRQoL). Content validity was determined as the strength of the association between the levels of PHQ-9-mFIN and the selected biopsychosocial factors. Results: The internal consistency of the PHQ-9-mFIN was high (Cronbach’s α=0.82) and the test-retest repeatability scores (n=65) fair: Pearson’s correlation 0.76, Kappa-value 0.42 for the diagnostic criterion (i.e. scores 0-9 vs. 10-27). Construct validity (Spearman correlation) against the Physical and Mental component items and their summary scales of the RAND 36 were much higher for the Mental (range -0.43 to -0.70 and -0.68) than for the Physical (range -0.06 to -0.41 and -0.24), respectively. There was a clear stepwise association (p<0.001) between the levels of depressive symptoms and General health (physical component, range 59.1 to 78.8). The associations with all items of the Mental components were strong and graded (p<0.001). All participants had low scores for Bodily pain regardless of the level of depressive symptoms. There was a strong association (p≤0.003) between levels of PHQ-9-mFIN and multisite pain, lumbar exertion and recovery after work days, neuromuscular fitness in Modified push-ups, workability, and fear of pain related to work. Conclusions: The PHQ-9-mFIN showed adequate reliability, and excellent construct and content validity among female healthcare workers with recurrent LBP and physically strenuous work. Trial registration: NCT01465698
Quality of Life in chronic musculoskeletal symptomatic Chilean population: Secondary analysis of National Health Survey 2009-2010
Authors: Mena-Iturriaga Maria Jesus , Mauri-Stecca Manuel Vicente , Sizer Phillip S. , Leppe Jaime 
Published: December 2019

Abstract
Background: Health-related quality of life (HRQoL) is defined as the patient's perception of their health status. The HRQoL can be modified by illnesses, treatments or social and health policies. Chronic pain is a modifying factor of HRQoL that leads to lower quality of life, elevated suffering and disability. Understanding potential quality of life variations in subjects with chronic musculoskeletal symptoms (cMSS) will provide information to health teams and organizations engaged in the Chilean health system. This study aim was to determine the relationship between HRQoL and musculoskeletal symptoms measured in three difference Chilean groups: (1) without symptoms; (2) with acute symptoms; and (3) with cMSS. Results were interpreted according to age, sex, educational level and residence area. Methods: This was accomplished using a secondary analysis of SF-12 data from the 2009-10 Chilean National Health Survey (NHS) using a multivariate logistic regression model to study the relationship between cMSS and HRQoL scores, adjusted for control variables. A 5% level of significance was considered. The STATA 15 was used for statistical analyses. Results: Out of 5,293 participants in the NHS 2009-10, 5,276 subjects were included for analysis. The median age was 46 years (IQR 31-60), 59.4% women, a median of 10 years formal education (IQR 7-12) and an urban residence in 85.2% of the population of the NHS 2009-10. The observed population prevalence of people with cMSS was 42.6% (95% CI 40.4 - 44.9). Presence of cMSS is a risk factor for low HRQoL, exhibited both in the physical (OR 3.1 95% CI 2.7-3.5) and mental (OR 1.9 95% CI 1.6-2,) HRQoL dimensions, independent of control variables. Conclusions: Physical and mental HRQoL are affected in people with cMSS, low educational level and advanced age. This is especially seen in women. This information will facilitate assessment and treatment of cMSS as a prevalent and multidimensional health problem.
The Chemical Structure and Bioactivity of Cycloartane-type Compounds
Authors: Gao Wenyan , Dong Xiaoyan , Wei Taiming , Xing Wenmin 
Published: December 2019

:
For decades now, compounds in the cycloartane-type series have been shown to
have versatile pharmacological activities. However, no extensive review has been written
to summarize these health-beneficial activities. Therefore, the purpose of this paper is to
systematically highlight the biological activities of these compounds, including their antitumor
and anti-osteoporosis effects, their effects on receptors, cytokine release, and
chronic renal failure, as well as their tyrosinase inhibitory, anticomplement, anti-parasite,
anti-HIV, and antituberculosis activities. In this review, we have summarized the structures
of over 200 compounds based on their characteristics and described their structureactivity
relationships (SARs), and potential mechanisms of action.
Mediterranean Diet and Osteoarticular Diseases
Authors: Sanpaolo Eliana R. , Corrado Addolorata , Cantatore Francesco P. 
Published: December 2019

Background:Besides the well-known positive effect on the reduction of the risk of cardiovascular diseases, in the latest decades growing evidence has accumulated on the beneficial effects of MD on various aspects of health outcomes. Nevertheless, data concerning the existence of a direct positive effect of MD, irrespective of its beneficial effect on body weight, in osteo-articular diseases, are still controversial. In osteo-articular diseases, a pro-inflammatory environment is highlighted, with an increased systemic levels of pro-inflammatory cytokines.Objective:Our objective is to investigate the effects of adherence to the Mediterranean diet and osteo-articular diseases.Conclusion:Many foods included in MD, have anti-inflammatory properties, due to the presence of nutrients, such as polyunsaturated (PUFA) and monounsaturated (MUFA) fats. The two types of polyunsaturated fatty acids, omega-3 and omega-6, have opposing effects on the inflammatory process. Omega-6 stimulates the production of pro-inflammatory cytokines, while omega-3 fatty acids exert anti-inflammatory effects, including significant reductions in the release of pro-inflammatory cytokines. Some studies have shown that the dietary pattern of MD consumption has an important role in the prevention and development of inflammatory arthritis. Nevertheless, the possible influence of MD on chronic osteo-articular diseases is very limited, this review updates the main experimental and clinical evidences concerning the potential beneficial effects of the Mediterranean Diet on the most diffuse osteo-articular chronic and degenerative joint disease.
Insights into the FDA 2018 New Drug Approvals
Authors: Bedair Alaa , Mansour Fotouh R. 
Published: December 2019

Objective:The Center of Drug Evaluation and Research (CDER) in the food and drug administration (FDA) approves new drugs every year. This review discusses the novel drugs of the FDA in 2018, with emphasis on the breakthrough drugs, the milestones in the approved list, and drugs with the highest expected sales in 2024.Methods:The following scientific search engines were surveyed for the clinical trials of the drugs approved by the FDA in 2018: Pubmed, Springer link, ScienceDirect, Scopus, Wiley online library, Taylor and Francis, and Google Scholar. The total forecast sales were compared based on information from the Cortellis database, EvaluatePharma, and Nature Biobusiness Briefs.Results:The 2018 year was full of good news for the drug market in the USA, with 59 new drug approvals by the FDA, which is the highest number of approvals in the last twenty years. The oncology and the antimicrobial drugs represent almost 50% of the new list, which gives hope to cancer patients and subjects with infectious diseases. In the 2018 FDA list, a number of drugs are expected to exceed 1$ billion dollars of sales by 2024.Conclusion:The new drugs approved by the FDA in 2018 have been reviewed. This year showed the highest number of new drug approvals in the last two decades. Among the 59 drugs approved in 2018, 14 drugs are considered breakthroughs, which revive hope for many poorly managed diseases. The list also contains 19 drugs that are first in class and 43 that were given priority reviews.
Alzheimer Disease Diagnosis from fMRI Images Based on Latent Low Rank Features and Support Vector Machine (SVM)
Authors: Shahparian Nastaran , Yazdi Mehran , Khosravi Mohammad Reza 
Published: December 2019

Introduction:
In recent years, resting-state functional magnetic resonance imaging (rsfMRI)
has been increasingly used as a noninvasive and practical method in different areas of neuroscience
and psychology for recognizing brain’s mechanism as well as diagnosing neurological
diseases. In this work, we use rs-fMRI data for diagnosing Alzheimer's disease.

Materials and Methods:
To do that, by using the rs-fMRI of a patient, we computed the time series
of some anatomical regions and then applied the Latent Low Rank Representation method to
extract suitable features. Next, based on the extracted features, we apply a Support Vector Machine
(SVM) classifier to determine whether the patient belongs to a healthy category, mild stage
of the disease or Alzheimer's stage.

Results:
The obtained classification accuracy for the proposed method is more than 97.5%.

Conclusion:
We performed different experiments on a database of rs-fMRI data containing the
images of 43 healthy subjects, 36 mild cognitive impairment patients and 32 Alzheimer’s patients
and the obtained results demonstrated that the best performance is achieved when the SVM with
Gaussian kernel and the features of only 7 regions were used.
Pengaruh pembelajaran POGIL berkonteks socioscientific issues terhadap kualitas keterampilan berargumentasi siswa SMA pada materi ikatan kimia
Authors: Astarina Anisyah Dasa , Rahayu Sri , Yahmin Yahmin 
Published: December 2019

Penelitian ini bertujuan untuk menguji pengaruh pembelajaran POGIL berkonteks SSI terhadap kualitas argumentasi siswa kelas X. Rancangan penelitian adalah mixed-methods. Data kuantitatif berupa tingkat kualitas argumentasi siswa yang diperoleh melalui instrumen tes keterampilan berargumentasi. Data kualitatif berupa hasil wawancara siswa tentang sikap siswa terhadap SSI dan argumentasi siswa pada proses pembelajaran. Hasil penelitian menunjukkan bahwa terdapat perbedaan keterampilan berargumentasi antara siswa yang dibelajarkan dengan POGIL berkonteks SSI dengan siswa yang dibelajarkan dengan POGIL dan konvensional. Pembelajaran POGIL berkonteks SSI lebih efektif dalam membelajarkan keterampilan berargumentasi siswa dibandingkan dua kelas lainnya berdasarkan nilai rata-rata kualitas argumentasi. The effect of POGIL with socioscientific issues context for high school argumentation skills quality in chemical bonding AbstractThe aim of the study was to examine the influence of POGIL with SSI context on the quality of high school students argumentation. The research design was mixed-methods. Quantitative data in the form of level of students’ argumentation quality collected by instrument of argument skills. Qualitative was the students’ transcript of interview about their attitude toward SSI and their argumentation in process of learning.The results showed that there was a difference in the skills of argumentation between the students who taught with the POGIL with SSI context and the students taught by POGIL and conventional instruction. POGILS with SSI context was more effective in teaching students’ argumentation skills compared to the other classes based on the average score of student argumentation.
Pengembangan modul berbasis keterampilan proses sains sebagai bahan ajar dalam pembelajaran biologi
Authors: Puspita Laila 
Published: December 2019

Studi ini bertujuan untuk mengetahui kemenarikan dan kelayakan dari modul berbasis keterampilan proses sains pada pembelajaran Biologi dalam materi sistem ekskresi pada manusia. Penelitian ini merupakan penelitian pengembangan atau Research and Development (R&D) yang terdiri dari tujuh langkah pengembangan, meliputi 1) potensi dan masalah, 2) pengumpulan data, 3) desain produk, 4) validasi desain, 5) revisi produk, 6) uji coba produk, 7) revisi produk. Adapun Teknik pengumpulan data menggunakan nontes berupa angket, wawancara, observasi. Instrumen yang digunakan berupa angket ahli materi, angket ahli desain media dan angket ahli bahasa dan angket respon siswa. Modul yang sudah dikembangkan divalidasi oleh 2 ahli materi, 2 ahli desain media, dan 2 ahli bahasa untuk mengetahui kelayakan produk. Hasil penilaian kelayakan modul berbasis keterampilan proses sains oleh ahli materi sebesar 92,5% dalam kategori sangat layak, penilaian oleh ahli desain sebesar 78,5% dalam kategori sangat layak, penilaian oleh ahli bahasa sebesar 90,5% dalam kategori sangat layak. Sedangkan hasil penilaian respon peserta didik memperoleh 74% dalam kategori menarik. Berdasarkan hasil penelitian ini dapat disimpulkan modul berbasis keterampilan proses sains pada pembelajaran Biologi layak dan menarik digunakan dalam materi sistem ekskresi pada manusia. Module development based on science process skills as teaching materials in biological learning AbstractThis study aims to determine the attractiveness and feasibility of modules based on science process skills in Biology learning in excretory system material in humans. This research is research and development (R & D) which consists of seven steps of development, including 1) potential and problems, 2) data collection, 3) product design, 4) design validation, 5) product revision, 6) trial products, 7) product revisions. The data collection techniques use non-test in the form of questionnaires, interviews, observations. The instruments are questionnaires for material experts, questionnaires for media design experts and questionnaires for linguists and student response questionnaires. The modules that have been developed are validated by 2 material experts, 2 media design experts, and 2 linguists to ascertain the feasibility of the product. The result of the feasibility assessment module based on science process skills by material experts is 92.5% in the very feasible category, the assessment by design experts is 78.5% in the very feasible category, the assessment by linguists is 90.5% in the very feasible category. While the results of the assessment of students’ responses are gained 74% in the interesting category. Based on the results of this study, it can be concluded that the module based on science process skills in Biology learning is feasible and interesting to be used in excretion system material in humans.
Pengaruh pembelajaran process oriented-guided inquiry learning berkonteks isu-isu sosiosaintifik dalam pembelajaran asam basa terhadap keterampilan berargumentasi siswa SMA kelas XI
Authors: Setyaningsih Arum , Rahayu Sri , Fajaroh Fauziatul , Parmin Parmin 
Published: December 2019

Kemampuan berargumentasi merupakan salah satu aspek dalam kemampuan berliterasi sains. Rendahnya skor pada survei PISA siswa Indonesia menunjukkan rendahnya kemampuan mereka dalam berargumen. Untuk mengatasi masalah tersebut, penelitian ini bertujuan untuk mengetahui perbedaan keterampilan berargumentasi dan kualitas argumentasi siswa yang dibelajarkan dengan model pembelajaran Process Oriented-Guided Inquiry Learning (POGIL) berkonteks isu-isu sosiosaintifik, POGIL, dan konvensional pada materi asam basa. Rancangan penelitian adalah eksperimen semu posstest only design. Sampel terdiri dari tiga kelas di salah satu SMAN di Kota Malang. Data diperoleh dari hasil tes keterampilan berargumentasi tertulis siswa. Hasil penelitian menunjukkan adanya perbedaan yang signifikan secara statistik terhadap keterampilan berargumentasi siswa di ketiga kelas penelitian (p=0.000). Kualitas argumentasi dianalisis menggunakan kerangka analitik Osborne. Pencapaian level argumentasi siswa kelas POGIL berkonteks isu-isu sosiosaintifik lebih tinggi daripada kelas POGIL dan konvensional. The effect of process oriented-guided inquiry learning with socioscientific issue contexts on high school students’ argument skills AbstractThe argumentation ability is one of aspect of scientific literacy. The low scores on PISA survey of Indonesian students showed their low ability in argumentation. To address this problem, this study aims to investigate the difference of students’argumentation skills who were taught using POGIL with socioscientific issues context, POGIL, and conventional learning. Research design was quasi-experimental postest only design. The sample consisted of three classes of a public senior high school in Malang. The data were obtained from students’ written argumentation. The result of this study showed significantly different statistic on students’argumetation skills in three classes (p=0,000). The quality of students’argumetation were classified using analytical framework by Osborne. Achievement of the argument level of POGIL class students contexted sociosaintific issues higher than POGIL class and conventional class.
A IMPLEMENTAÇÃO DO PROGRAMA BOLSA-FAMÍLIA SOB A PERSPECTIVA DA CONDICIONALIDADE EDUCACIONAL: UMA ANÁLISE A PARTIR DOS AGENTES PÚBLICOS DE BASE
Authors: Oliveira Breynner R. 
Published: December 2019

Este artigo analisa a implementação do Programa Bolsa-Família na cidade de Belo Horizonte, a partir dos agentes de base (street-level bureaucrats), sob a perspectiva da condicionalidade educacional. O programa transfere uma bolsa para famílias em situação de pobreza, vinculando o pagamento ao cumprimento de co-responsabilidades nas áreas da educação e saúde. Lipsky (1980) é uma referência neste campo porque, ao analisar esse processo a partir da perspectiva dos atores que estão na ponta, assume que tais agentes exercem influência sobre essas políticas, alterando seu curso de ação. Nesta cidade, os profissionais da educação e da assistência são os que correspondem à caracterização do autor. As 31 entrevistas realizadas indicam que há tipos diferentes de interação, explicados pelas distintas percepções, valores e interpretações que esses atores constroem quando desempenham suas funções, estimulando o fortalecimento de redes de cooperação. A pesquisa revela que essa condicionalidade mobiliza os agentes de base, mesmo quando a intersetorialidade ainda é um problema institucional. Palavras-chave: Bolsa-Família; street-level bureaucracy; implementação; agentes públicos de base
Analisis Etika Kerja Islam dan Etika Penggunaan Komputer terhadap Ketidaketisan Penggunaan Komputer oleh Pengguna Teknologi Informasi di UMKM Kabupaten Bantul
Authors: Hidayah Nila 
Published: December 2019

Dalam ilmu akuntansi forensik sistem informasi menjadi bagian yang tidak dapat dipisahkan, terutama mengenai etika dalam penggunaan teknologi informasi khususnya komputer sebagai media pembelajaran dan media bekerja. Pada setiap lini perlu melakukan pengambilan keputusan secara tepat yaitu dengan melakukan investasi teknologi di dalam organisasi. Salah satunya implementasi terhadap teknologi komputer yang dapat membawa perubahan besar (perubahan yang terjadi pada cara berpikir manusia, baik dalam usaha pemecahan masalah, perencanaan, maupun pengambilan keputusan) disegala sisi kehidupan yang sedikit banyak akan berpengaruh terhadap pelaksanaan dan cara pandang manusia terhadap etika dan norma-norma dalam kehidupannya. Tujuan dari penelitian ini adalah untuk menentukan sejauh mana penggunaan komputer yang tidak etis oleh pengguna teknologi informasi. Hasil penelitian menunjukkan bahwa etika kerja (Islam) tidak berpengaruh terhadap etika penggunaan komputer. Etika penggunaan komputer berpengaruh positif terhadap ketidaketisan penggunaan komputer. Sedangkan jenis kelamin sebagai faktor moderasi tidak berpengaruh terhadap ketidaketisan penggunaan komputer. Demikian pula, pengalaman kerja sebagai faktor moderasi tidak mempengaruhi ketidaketisan penggunaan komputer
Penerapan Model Project Based Learning (PBL) Untuk Meningkatkan Kreatifitas dan Prestasi Belajar Siswa pada Kompetensi Desain Produk dan Pengemasan Karya Rekayasa Elektronika Praktis Di Kelas XII IPS2
Authors: Budi Sihono Setyo 
Published: December 2019

<p>Penelitian ini betujuan untuk mengetahui mengetahui apakah Model Project Based Learning (PBL) dapat meningkatkan kreatifitas dan prestasi belajar di kelas XII IPS<sub>2</sub> MAN I Kulon progo. Subyek penelitian ini adalah siswa MAN Wates I Kulon Progo kelas XII IPS<sub>2</sub> sebanyak 30 siswa. Data diperoleh dengan menggunakan lembar obsevasi, analisa data menggunakan kuantitatif dan kualitatif. Dari analisa ditemukan bahwa Model Project Based Learning (PBL) dapat meningkatkan kreatifitas dan prestasi belajar. Terlihat terdapat peningkatan yang signifikan antara siklus I, siklus II dan siklus III. Jumlah skor rata-rata kreatifitas belajar pada siklus I sebesar 55 dan pada siklus II sebesar 72 dan siklus III sebesar 76. Presasi belajar juga mengalami peningkatan yang signifikan antara siklus I, siklus II dan siklus III. Jumlah skor rata-rata prestasi belajar pada siklus I sebesar 68,33, pada siklus II sebesar 71,25 dan siklus III sebesar 74,86. Capaian proyek yang dilaksanakan siswa juga mengalami peningkatan, pada siklus I sebesar 85,6 %, siklus II sebesar 88,9 % dan siklus III sebesar 92,2%. </p><p> </p><p>Kata Kunci : Model Project Based Learning, Kreatifitas Belajar, Prestasi Belajar </p>