bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of vitamin K dietary supplementation in pulmonary dysfunction induced by 7,12‐dimethylbenz[a]anthracene in rat
Authors: Dosumu Oluwatosin A. , Rotimi Solomon O. , Akintunde Jacob , Adeleye Oluwagbemiga O. , Sani Latifah O. , Omotosho Oluwatosin O. , Osinuga Kehinde T. , Taiwo Odunayo A. , Ojo Oluwafemi A. 
Published: July 2020

AbstractOne of the well‐known toxicants of the mammary tissue is 7,12‐dimethylbenz[a]anthracene (DMBA). This study was carried out to investigate the possible prophylactic's role of increased dietary intake of vitamin K on the induction of toxicity in the lung tissue. Twenty‐eight Wistar albino rats (120‐150 g) were randomly divided into different groups. Group 1 served as the control and were fed with a normal diet (containing the recommended daily allowance of vitamin K (0.0075%)). Groups 2 and 3 received a single dose of DMBA (80 mg/kg body weight) intragastically. In addition, group 3 rats were maintained on surplus vitamin K diet (0.075% diet) as against the group 2 animals that were on a normal diet. Group 4 rats were on surplus vitamin K diet (0.075% diet) throughout the experimental period of 16 weeks. Our results revealed that supplementation of diet with surplus vitamin K significantly increased the activities of catalase. Superoxide dismutase, glutathione‐S‐transferase, and glutathione peroxidase were significantly increased in the serum and lungs when compared with the DMBA‐treated group, which was maintained on a normal diet. Significant alterations in malondialdehyde, nitric oxide, granulocyte‐macrophage colony‐stimulating factor, and interleukin 17F were observed in rats challenged with DMBA‐fed normal diets but were normalized in rats with surplus vitamin K. These alterations and reversal were confirmed by histopathology studies. This suggests the prophylactic benefit of increased dietary intake of vitamin K without any observed deleterious effect on DMBA‐induced pulmonary toxicity.
The pain of grief: Exploring the concept of psychological pain and its relation to complicated grief, depression, and risk for suicide in bereaved adults
Authors: Frumkin Madelyn R. , Robinaugh Donald J. , LeBlanc Nicole J. , Ahmad Zeba , Bui Eric , Nock Matthew K. , Simon Naomi M. , McNally Richard J. 
Published: July 2020

AbstractObjectiveEmotional or psychological pain is a core symptom of complicated grief (CG), yet its correlates are largely unexamined among bereaved individuals.MethodBereaved adults (N = 135) completed self‐reports regarding psychological pain, CG, depression, and suicidality. We assessed correlations among these variables and tested whether psychological pain was elevated among individuals with CG and individuals with current or past suicidal thoughts and behaviors. Using logistic regression, we also assessed psychological pain, depression, and CG symptom severity as predictors of suicide risk.ResultsPsychological pain was strongly associated with both CG and depression severity and was elevated among subjects reporting current or past suicidality. CG and depression were not statistically significant predictors of suicidal ideation after accounting for the effects of psychological pain.ConclusionsPsychological pain is strongly associated with bereavement‐related psychopathology and warrants further investigation in studies examining the nature and treatment of CG.
Role of panic appraisal in predicting the severity of panic and agoraphobic symptoms
Authors: Cho Yongrae , Choi Younghee , Kim Sunyoung 
Published: July 2020

AbstractObjectiveThe present study examined the contribution of panic appraisal (PA) dimensions to the prediction of panic and agoraphobic symptoms, above and beyond anxiety sensitivity (AS), among patients with panic disorder. PA dimensions consist of anticipated panic, perceived panic consequences, and panic coping efficacy.MethodPanic disorder patients (N = 84, 60.7% female, M = 38 years) completed self‐report measures of panic and agoraphobic symptoms, three dimensions of PA, AS, anxiety, and depression symptoms.ResultsPA dimensions significantly contributed to the prediction of overall and all facets of panic and agoraphobic symptoms, as well as anxiety symptoms, but not depressive symptoms, above and beyond AS. Of the three PA dimensions, both anticipated panic and panic coping efficacy uniquely contributed to agoraphobic avoidance after controlling for AS and the other dimensions of PA.ConclusionPA dimensions may emerge as an important predictor of panic and agoraphobic or anxiety symptoms.
Etoposide‐based treatment of adult HLH is associated with high biochemical response but poor survival outcomes
Authors: Nicholson Matthew C. , Naeije Leonie , Hayden Anna R. , Mattman Andre , Dix David , Chen Luke Y.C. 
Published: July 2020

AbstractEtoposide‐based treatment is the standard of care for adult HLH in many centers, yet there remains a paucity of data regarding treatment outcomes. We conducted a retrospective study of 23 adults treated with etoposide‐based therapy compared to 10 pediatric HLH cases at a single center. At diagnosis, the median serum ferritin was 20,071 µg/L and 937 µg/L in adults and children, respectively; median sIL‐2r was 14,524 U/mL and 4,478 U/mL. Biochemical response to treatment was high, with 21/23 adults achieving >75% reduction in serum ferritin, but one year survival was only 7/21 compared to 7/10 in pediatric cases.
Green synthesis of pyrrolo isoquinolines using in situ synthesis of 4‐hydroxycumarines: Study of antioxidant activity
Authors: Mousavi Seyyedeh Fatemeh , Hossaini Zinatossadat , Rostami‐Charati Faramarz , Nami Navabeh 
Published: July 2020

AbstractIn this research, synthesis of pyrrolo isoquinoline derivatives in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2‐hydroxyacetophenone, or its derivatives, dimethyl carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°C. The Punica granatum peel water extract was used as the green media for the synthesis of PG‐KF/clinoptilolite nanoparticles in high yield. The PG‐KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl‐picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure.
Clinical neurophysiology and cerebrospinal liquor analysis to detect Guillain‐Barré syndrome and polyneuritis cranialis in COVID‐19 patients: A case series
Authors: Manganotti Paolo , Bellavita Giulia , D'Acunto Laura , Tommasini Valentina , Fabris Martina , Sartori Arianna , Bonzi Lucia , Buoite Stella Alex , Pesavento Valentina 
Published: July 2020

AbstractWe report a case series of five patients affected by SARS‐CoV‐2 who developed neurological symptoms, mainly expressing as polyradiculoneuritis and cranial polyneuritis in the 2 months of COVID‐19 pandemic in a city in the northeast of Italy. A diagnosis of Guillain‐Barré syndrome was made on the basis of clinical presentation, cerebrospinal fluid analysis, and electroneurography. In four of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 g/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases a significant decrease in amplitude of compound motor action potential compound muscle action potential (cMAP). Four patients presented a mild facial nerve involvement limited to the muscles of the lower face, with sparing of the forehead muscles associated to ageusia. In one patient, taste assessment showed right‐sided ageusia of the tongue, ipsilateral to the mild facial palsy. In three patients we observed albuminocytological dissociation in the cerebrospinal fluid, and notably, we found an increase of inflammatory mediators such as the interleukin‐8. Peripheral nervous system involvement after infection with COVID‐19 is possible and may include several signs that may be successfully treated with immunoglobulin therapy.
Performance of model‐based network meta‐analysis (MBNMA) of time‐course relationships: A simulation study
Authors: Pedder Hugo , Boucher Martin , Dias Sofia , Bennetts Margherita , Welton Nicky J. 
Published: July 2020

AbstractTime‐course model‐based network meta‐analysis (MBNMA) has been proposed as a framework to combine treatment comparisons from a network of randomized controlled trials reporting outcomes at multiple time‐points. This can explain heterogeneity/inconsistency that arises by pooling studies with different follow‐up times and allow inclusion of studies from earlier in drug development. The aim of this study is to explore using simulation: (a) how MBNMA model parameters are affected by the quantity/location of observed time‐points across studies/comparisons, (b) how reliably an appropriate MBNMA model can be identified, (c) the robustness of model estimates and predictions under different dataset characteristics. Our results indicate that model parameters for a given treatment comparison are estimated with low mean bias even when no direct evidence was available, provided there was sufficient indirect evidence to estimate the time‐course. A staged model selection strategy that selects time‐course function, then heterogeneity, then covariance structure, identified the true model most reliably and efficiently. Predictions and parameter estimates from selected models had low mean bias even in the presence of high heterogeneity/correlation between time‐points. However, failure to properly account for heterogeneity/correlation could lead to high error in precision of the estimates. Time‐course MBNMA provides a statistically robust framework for synthesizing direct and indirect evidence to estimate relative effects and predicted mean responses whilst accounting for time‐course and incorporating correlation and heterogeneity. This supports the use of MBNMA in evidence synthesis, particularly when additional studies are available with follow‐up times that would otherwise prohibit their inclusion by conventional meta‐analysis.
Investigating the utility of extended mutation analysis in gastrointestinal peritoneal metastasis
Authors: Foster Jason M. , Patel Asish , Zhang Chunmeng , Shostrom Valerie , Brown Krista , Cushman‐Vokoun Allison M. 
Published: July 2020

AbstractBackground and ObjectivesOutcomes for gastrointestinal peritoneal metastases (GI‐PM) are worse compared to systemic metastases, with a paucity of data exploring extended mutation profiling. An exploratory mutation analysis in GI‐PMs was performed as a “proof of concept” of potential predictive values of profiling in GI‐PM and rates of actionable mutations.MethodsThe study included 40 GI‐PM patients: 14 low‐grade mucinous carcinoma peritonei and 26 HG‐PM (12 colons, 10 appendix, 4 small bowels). Demographics, histologies, peritoneal cancer indexes, cytoreduction scores, and survival data were collected. NGS 50‐gene mutation profiling was performed on 38 specimens. The association of mutations with survival was evaluated in high‐grade PM.ResultsKRAS, TP53, and SMAD4 mutations were observed in 61%, 29%, and 8% of cases across all tumor histologies. In 66% cases >1 mutations occurred, associated with decreased survival in HG‐PM: 32 vs 73 months, P = .03. TP53 or SMAD4 mutations were associated with decreased survival in HG‐PM: 22 vs 48 months, P = .02. Actionable mutations were detected in 70%.ConclusionActionable mutations were detected at high rates. GI‐PMs have similar mutational profiles and TP53, SMAD4, and/or >1 mutation were associate with decreased survival in HG‐PM. This data supports the concept of the extended mutation profiling utility in GI‐PM warranting further investigation.
Prolonged Exposure and Sertraline Treatments for Posttraumatic Stress Disorder Also Improve Multiple Indicators of Social Functioning
Authors: Graham Belinda , Garcia Natalia M. , Bergman Hannah E. , Feeny Norah C. , Zoellner Lori A. 
Published: July 2020

AbstractTrauma survivors with posttraumatic stress disorder (PTSD) frequently also suffer from difficulties in social functioning that range across emotional, cognitive, and environmental domains. A detailed evaluation of the differential impacts of effective PTSD treatments on social functioning is needed. Men and women (N = 200) with chronic PTSD received 10 weeks of prolonged exposure (PE) or sertraline in a randomized clinical trial and were followed for 24 months. A secondary data analysis examined changes in social functioning with regard to fear of intimacy; receipt of social support; and distress, avoidance, and negative cognitions in social situations. Effects were examined between treatments over time, controlling for baseline functioning. There were large, durable improvements across all indices. Compared to sertraline, PE was more efficient at reducing fear of intimacy and distress from negative social cognitions by posttreatment, ds = 0.94–1.14. Patients who received sertraline continued to improve over the course of follow‐up, ds = 0.54–1.17. The differential speed of therapeutic effects may argue for more direct mechanisms in cognitive behavioral interventions versus cascade effects in serotonin reuptake inhibitors. Notably, both treatments produced substantial social benefits for trauma survivors with social functioning difficulties, and effect sizes were comparable to typical reductions in PTSD, depression, and anxiety.
Idiopathic Non‐task‐Specific Upper Limb Dystonia, a Neglected Form of Dystonia
Authors: Defazio Giovanni , Ercoli Tommaso , Erro Roberto , Pellicciari Roberta , Mascia Marcello Mario , Fabbrini Giovanni , Albanese Alberto , Lalli Stefania , Eleopra Roberto , Barone Paolo , Marchese Roberta , Ceravolo Roberto , Scaglione Cesa , Liguori Rocco , Esposito Marcello , Bentivoglio Anna Rita , Bertolasi Laura , Altavista Maria Concetta , Bono Francesco , Pisani Antonio , Girlanda Paolo , Berardelli Alfredo ,   Italian Dystonia Registry Participants
Published: July 2020

AbstractObjectiveThe objective of this study was to describe the clinical and demographic features of idiopathic non‐task‐specific upper limb dystonia compared with the task‐specific form.MethodsIn this retrospective study, adult patients with idiopathic upper limb dystonia, either focal or as part of a segmental/multifocal dystonia, from the Italian Dystonia Registry were enrolled. In patients with focal upper limb dystonia, dystonia spread was estimated by survival analysis.ResultsOf the 1522 patients with idiopathic adult‐onset dystonia included in the Italian Dystonia Registry, we identified 182 patients with upper limb dystonia. Non‐task‐specific dystonia was present in 61.5% of enrolled cases. Women predominated among non‐task‐specific patients, whereas men predominated in the task‐specific group. Peak age of upper limb dystonia onset was in the sixth decade in the non‐task‐specific group and in the fourth decade in the task‐specific group. In both groups, upper limb dystonia started as focal dystonia or as part of a segmental dystonia. Segmental onset was more frequent among non‐task‐specific patients, whereas focal onset predominated among task‐specific patients. Dystonic action tremor was more frequent among non‐task‐specific patients. No significant differences between groups emerged in terms of sensory trick frequency, rest tremor, or family history of dystonia. In patients with focal upper limb dystonia, dystonia spread was greater in the non‐task‐specific group.ConclusionNovel information on upper limb dystonia patients suggests that non‐task‐specific and task‐specific upper limb dystonia have different demographic and clinical features. However, it remains to be determined whether these differences also reflect pathophysiological differences. © 2020 International Parkinson and Movement Disorder Society
Derivation of formulae and optimal design for Owen's resistive power divider
Authors: Kim In‐Seon , Kim Ghiback , Park Jin Tae , Jang Yeon Soo , Park Beom Jun 
Published: July 2020

AbstractA modified resistive power divider (RPD) was proposed by Owen and this structure has been shown to have higher isolation than a conventional RPD. However, it has a large insertion loss, which is a disadvantage. No theoretical studies have been published since Owen proposed this unique structure with specific resistor values. Thus far, the improvement of insertion loss has been achieved by trial and error to optimize performance by varying the resistor values. In this study, we perform a circuit analysis of the Owen's RPD and derive formulae to calculate performance. From the measured results, we demonstrate the validity of the derived formulae and show that the insertion loss could be improved by trade‐offs between performance.
Sacral nerve stimulation for refractory OAB and idiopathic urinary retention: Can phenotyping improve the outcome for patients: ICI‐RS 2019?
Authors: Malde Sachin , Marcelissen Tom , Vrijens Desiree , Apostolidis Apostolos , Rahnama'I Sajjad , Cardozo Linda , Lovick Thelma 
Published: July 2020

AbstractAimsSacral nerve stimulation (SNS) is widely used to treat refractory idiopathic overactive bladder (OAB) and idiopathic urinary retention. However, clinical outcomes are variable and understanding predictive factors for success or side‐effects would enable personalization of therapy and optimization of outcomes. At the International Consultation on Incontinence‐Research Society meeting 2019, a Think Tank was convened to discuss how advances in the basic science study of SNS may be translatable into clinical practice to improve outcomes of patients undergoing SNS treatment.MethodsWe conducted a literature review and expert consensus meeting focusing on current methods of phenotyping patients and specifically, how advances in basic science research of the mechanism of action of SNS can be translated into clinical practice to improve patient selection for therapy.ResultsThe terms “Idiopathic OAB” and “idiopathic urinary retention” encompass several underlying pathophysiological phenotypes. Commonly, phenotyping is based on clinical and urodynamic factors. Animal studies have demonstrated that high‐frequency stimulation can produce rapid onset, reversible conduction block in peripheral nerves. Altering stimulation parameters may potentially enable personalization of therapy depending upon the clinical indication in the future. Similarly, advances in conditional and closed‐loop stimulation may offer greater efficacy for certain patients. Phenotyping based on psychological comorbidity requires further study to potentially optimize patient selection for therapy.ConclusionsIdiopathic OAB and idiopathic urinary retention are heterogenous conditions with multiple potential underlying phenotypes. Tailoring stimulation parameters to the needs of each individual according to phenotype could optimize outcomes. Assessing psychological comorbidity may improve patient selection. Areas for further research are proposed.
A better buy‐one‐give‐one business model
Authors: Yen Pi‐Ying , Chen Ying‐Ju , He Qiao‐Chu 
Published: July 2020

AbstractBuy‐one‐give‐one is a prevailing business model among social enterprises nowadays. Under this model, for every product sold, a social enterprise will donate the same or a similar product to a person in need. However, two questions arise: Should the social enterprise stick to donating the same product? Should the social enterprise stick to donating one product? In this paper, we explore different formats of buy‐one‐give‐one and compare buy‐one‐give‐one with cross‐subsidy with regard to social welfare, including both financial payoff and social payoff. The findings show that the social enterprise can generate more social welfare by differentiating its products into high‐end products for purchasers (the rich) and low‐end products for recipients (the poor) instead of providing these two segments products of the same quality. Also, giving more than just one product to the poor when one product is sold is an effective way to increase social welfare. We find that buy‐one‐give‐one results in higher social welfare than cross‐subsidy when either the social enterprise is highly socially responsible or the social gap between the rich and the poor is significant. However, when the size of the rich population is negligible, the buy‐one‐give‐one business model no longer pays. The social welfare under cross‐subsidy is at least the same as that under buy‐one‐give‐one in this case.
Evaluation of the wound healing process in rat skin using a hexanoyl group‐modified alkaline‐treated gelatin porous film
Authors: Koga Takashi , Kibe Toshiro , Taguchi Tetsushi , Fuchigami Takao , Nishihara Kazuhide , Ishihata Kiyohide , Nakamura Norifumi 
Published: July 2020

AbstractThe present study investigated the wound healing process in a rat skin wound model dressed with a hexanoyl group‐modified alkaline‐treated gelatin porous (HxAlGltn) film with angiogenesis‐inducing and strong bioadhesive properties or a collagen sponge (CS). A circular 10‐mm full‐thickness skin defect was created on the backs of 8‐week‐old rats and then dressed with a HxAlGltn film (HxAlGltn group), collagen sponge (CS group), and no dressing (control group). Wound distances and areas were assessed macroscopically at specific time points after surgery, the lengths and thicknesses of the neo‐epithelium histologically, and α‐smooth muscle actin (α‐SMA), collagen type I, and fibronectin immunohistochemically. Wound distances and areas were significantly greater in the HxAlGltn group than in the CS and control groups. The expression of α‐SMA in myofibroblasts was significantly weaker in the HxAlGltn group than in the other groups on day 7. Furthermore, angiogenesis was prominent on days 4 and 7 in the HxAlGltn group. No significant differences were observed in the length of the neo‐epithelium between all groups, whereas the thickness of the neo‐epithelium was greater in the HxAlGltn group than in the CS group. The present results suggest the potential of the HxAlGltn film as a dressing material in the wound healing process of full‐thickness skin defects because it reduces scar contraction and promotes angiogenesis more than CS.
Screen pattern simulation for an improved front‐side Ag‐electrode metallization of Si‐solar cells
Authors: Tepner Sebastian , Ney Linda , Linse Michael , Lorenz Andreas , Pospischil Maximilian , Masuri Kenji , Clement Florian 
Published: July 2020

AbstractFlatbed screen printing proves to be the dominant metallization approach for mass production of silicon (Si)‐solar cells because of its robust and cost‐effective production capability. However, the ongoing demand of the PV industry to further decrease the width of printed Ag‐electrodes (contact fingers) requires new optimizations. This study presents the latest results on Si‐solar cell metallization using fine‐line screens down to screen opening widths of wn = 15 μm. The best experimental group achieved a record finger geometry with a mean finger width of wf = 19 μm and a mean finger height of hf = 18 μm. Furthermore, solar cell performance using a front‐side grid with a screen opening width of wn = 24 μm is investigated, reporting cell efficiencies up to 22.1% for Passivated Emitter and Rear Contact (PERC) solar cells. Finally, a novel screen pattern simulation is presented, revealing a correlation between the measured lateral finger resistance and the novel dimensionless parameter screen utility index (SUI). It describes the ratio between the average size of individual openings defined by the screen mesh angle and the chosen underlying mesh type. For SUI < 1, the printing result will strongly depend on the screen configuration, whereas for values of SUI > 1, the impact of the screen on the overall printability diminishes.