bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sertoli Cell Tumors of the Testes: Systematic Literature Review and Meta-Analysis of Outcomes in 435 Patients
Authors: Grogg Josias , Schneider Kym , Bode Peter Karl , Kranzbühler Benedikt , Eberli Daniel , Sulser Tullio , Lorch Anja , Beyer Joerg , Hermanns Thomas , Fankhauser Christian Daniel 
Published: February 2020

Abstract

Background
Sertoli cell tumors (SCTs) of the testes are rare, and the literature provides only weak evidence concerning their clinical course and management. The objective of this study was to summarize evidence on SCTs’ clinical presentation, clinicopathological risk factors for malignancy, treatment options, and oncological outcomes.

Materials and Methods
Data sources included Medline, Embase, Scopus, the Cochrane Database of Systematic Reviews, and Web of Science. Published case reports, case series, and cohorts were included. Data on clinicopathological variables, treatment of local or metastatic disease, site of metastasis, or survival were extracted from each study considered in this paper, and associations between clinicopathological variables and metastatic disease were analyzed. Whenever feasible, data on individual patients were collected.

Results
Of the 435 patients included, only one (&lt;1%) showed local recurrence after testis-sparing surgery (TSS). Three patients underwent adjuvant retroperitoneal lymphadenectomy. Fifty patients presented with metastases, located in the retroperitoneal lymph nodes (76%), lungs (36%), and bones (16%); median time to recurrence was 12 months. Risk factors for metastatic disease included age, tumor size, necrosis, tumor extension to the spermatic cord, angiolymphatic invasion, and mitotic index. Patients with metastases had a median life expectancy of 20 months. In six patients, metastasectomy resulted in complete remission.

Conclusion
Our findings suggest that few local recurrences result after TSS, and no adjuvant therapy can be regarded as a standard of care. Several risk factors are predictive of metastatic disease. Surgery leads to remission in metastatic disease, whereas systemic treatment alone does not result in long-term remission.

Implications for Practice
Testicular Sertoli cell tumors usually present without metastatic disease and show low local recurrence rates after testis-sparing surgery; no adjuvant therapy option can be regarded as a standard of care. Patients with risk factors should undergo staging investigations. Those with metastatic disease have poor prognoses, and metastasectomy may be offered in selected cases.
Agony and the Collapse of Semenov
Authors: Gordeev Nikolay 
Published: February 2020

The journal Russian-Chinese Studies (iss. 3–4(3), 2018) published an extensive article by V.I. Mertsalov Political “Face” of Chieftain Semenov (the History of the Civil War in the Far East). The author having analyzed a wide range of literature traced the evolution of political views of the chieftain and made a number of fundamental conclusions. According to the author, with all the diversity of views and actions of Semenov, they were consistently anti-Soviet and anti-communistic which is clearly reflected in the thesis formulated by the ataman: “…Where there is bolshevism, there is no Russia”. We can’t but agree with this author's argument. And yet, with all the variety of scientific publications on this issue, it is useful to continue the historical research, fully revealing all the criminal activities of the chieftain. Especially in recent years when among the representatives of the TRANS-Baikal “white” Cossacks and some local historians propaganda has intensified to reconsider the verdict of the USSR Military Board of the Supreme Court to chieftain Semenov and his subsequent rehabilitation. The reason for this is the “newly discovered circumstances” — declassified documents that allegedly indicate that “the charges against the chieftain are absurd, and the investigation and trial against him were conducted in violation of the law”. Therefore, “reviewing the Semenov case would play a positive role in reconciling Russian society”. Proponents of rehabilitation deliberately hide that during his life the chieftain got the infamous nickname “bloody” for what he did to the country. What kind of “reconciliation” — whom and with whom — can we talk about? In this regard, the author of this article offers his own vision of the chieftain case referring to his previous published research in scientific journals and the media.
Ketone body supplement label claims: what supplement has been supplemented?
Authors: Da Costa D , Bangalee V , Subban K , Naidoo R 
Published: February 2020

Background: There is a keen interest in performance-enhancing supplementation and the associated benefits, despite reports of incorrect label claims made by manufacturers and the questionable efficacy of the supplements. The use of ketone body supplements as a source of fuel during exercise and sporting performance, in particular, is of interest to sportspeople. By increasing blood ketone body levels, with an accompanying decrease in blood glucose, may indicate a state of nutritional ketosis, whereby the body no longer relies on glucose metabolism but rather the metabolism of ketone bodies. This could be beneficial for long, slow steady-state endurance exercise.
Discussion: There are numerous ketone body supplements on the market manufactured in South Africa and internationally. However, unlike medicines, the sports supplementation industry is poorly regulated. Furthermore, ketone body supplementation with regard to its effects on improving exercise and athletic performance is still unconvincing.
Conclusion: Within the ever-changing sports supplementation industry, ketone body supplements are being used despite controversies regarding the accuracy and scientific merit of label claims. The ingredients and their quantities, as well as the performance benefits, need to be objectively validated.
Prevalencia de tabaquismo en una población de embarazadas en el Hospital Universitario San Vicente de Paúl en Medellín (Colombia)
Authors: Cortés-Yepes Hernán 
Published: February 2020

Objetivo: determinar la prevalencia del tabaquismo durante el embarazo y sus factores asociados.Materiales y métodos: estudio de corte transversal en pacientes gestantes a quienes se les realizó una encuesta en el servicio de Medicina Materno Fetal del Hospital Universitario de la Fundación San Vicente de Paúl en Medellín, en el período de septiembre de 2009 a noviembre de 2010. Se realizó un muestreo secuencial consecutivo estricto. Se evaluó la prevalencia del consumo de tabaco, el porcentaje de suspensión durante la gestación, la edad y el número de hijos.Resultados: se realizaron 2171 encuestas. La prevalencia de tabaquismo fue de 7,3%, (IC 95% 6,3 - 8,5), de éstas el 56% (90gestantes) dejaron de fumar cuando se enteraron de su embarazo. En las 70 pacientes que continuaron fumando el promedio de consumo fue de 7,2 cigarrillos al día.Conclusión: el consumo de cigarrillo durante el embarazo es un problema que afecta a nuestras gestantes. Se deben hacer nuevos estudios de tipo poblacional de mayor cobertura para evaluar con mayor precisión la magnitud del problema.
Morbilidad materna extrema en cuidados intensivos obstétricos. Cartagena (Colombia) 2006 - 2008
Authors: Rojas José A. , Cogollo Marysabel , Miranda Jezid E. , Ramos Enrique C. , Fernández Juan C. , Bello Ana M. 
Published: February 2020

Objetivo: el presente estudio tiene como objetivo establecer la incidencia de la morbilidad materna extrema (MME), sus características clínicas y hacer una primera aproximación a los indicadores de calidad de la atención obstétrica en la unidad de cuidados intensivos (UCI).Materiales y métodos: estudio de cohorte, retrospectivo de pacientes obstétricas con MME que ingresaron a la UCI de la Clínica de Maternidad Rafael Calvo de Cartagena entre el período del 1 de enero de 2006 al 31 de diciembre de 2008. Se registraron las características sociodemográficas, ginecoobstétricas, criterios de MME y los indicadores de calidad de la atención obstétrica. Para el análisis de resultados se utilizaron medidas de tendencia central y dispersión, porcentajes, tablas de frecuencia y razones estandarizadas de morbilidad con intervalos de confianza (IC) al 95%.Resultados: la incidencia de MME fue de 12,1 por 1000 nacimientos. El 27,2% (88 pacientes) eran adolescentes y el 61,6% multigestantes (199 pacientes). El principal diagnóstico asociado a la MME fue el trastorno hipertensivo del embarazo, 49,5% (160 pacientes), seguido por las hemorragias del embarazo, 22,6% (73 pacientes). Las principales disfunciones orgánicas fueron respiratorias, 38,1% (123 casos), hepáticas, 15,2% (49 casos) e inmunológicas, 14,6% (47 casos). La transfusión fue la intervención más común, 22,6% (73 pacientes). Durante los años de estudio la incidencia de MME y la razón de casos de MME: muerte materna (MM) aumentaron, mientras que el índice de mortalidad disminuyó.Conclusiones: se encontró una incidencia de MME del 12,1 por 1000 nacimientos. Se presentaron los indicadores de calidad como medición basal, lo que servirá de comparación para futuras mediciones.
Papel de la cistoscopia en el estudio de las pacientes con dolor pélvico crónico: estudio observacional
Authors: Villegas-Echeverri Juan Diego , López-Jaramillo José Duván , León-Avellaneda José William , Restrepo-Santa Lina Marcela 
Published: February 2020

Objetivo: este estudio busca describir los hallazgos cistoscópicos en un grupo de pacientes con dolor pélvico crónico (DPC) que consultaron a una clínica de referencia en Pereira (Colombia).Materiales y métodos: es un estudio de corte transversal en mujeres que consultaron la clínica en el período comprendido entre julio de 2006 y octubre de 2008, por dolor pélvico crónico a una institución hospitalaria de 4° nivel y centro de remisión; y que fueron sometidas a laparoscopia y cistoscopia. Por medio de un formulario se extrajeron los datos de las historias clínicas. También se describe la prevalencia de cistitis intersticial y trigonitis crónica.Resultados: 115 mujeres con DPC fueron sometidas a laparoscopia y cistoscopia bajo anestesia general. El 59% de las pacientes tenían hallazgos cistoscópicos de cistitis intersticial. Los síntomas de frecuencia urinaria aumentada, disuria y nicturia tuvieron una correlación estadísticamente significativa con los hallazgos anormales en la cistoscopia. El principal signo hallado en el examen físico fue el dolor al palpar la vejiga. El test de cloruro de potasio tuvo una sensibilidad del 71%, una especificidad del 44%, un Valor Predictivo Positivo (VPP) del 60% y un Valor Predictivo Negativo (VPN) del 57%.Conclusiones: en pacientes con dolor pélvico crónico y síntomas urinarios se encuentra una alta prevalencia de cistitis intersticial y trigonitis crónica.
Pentalogía de Cantrell en el primer gemelo de un embarazo gemelar monocigótico: presentación de un caso y revisión de la literatura
Authors: Pachajoa Harry 
Published: February 2020

Introducción: la Pentalogía de Cantrell (PC) se compone de cinco anomalías: defecto superior de pared abdominal, defecto esternal inferior, defecto diafragmático anterior, defecto pericárdico diafragmático y anormalidades del corazón. Cerca de 250 casos han sido reportados, solo 6 involucran gemelos, y de estos 4 describen discordancia de esta anomalía.Objetivo: realizar la presentación de un caso de PC asociado a embarazo gemelar y la revisión de la literatura de esta asociación con énfasis en el diagnóstico prenatal y la etiología.Materiales y métodos: se presenta un caso de Pentalogía de Cantrell que afecta solo al primer gemelo de un embarazo gemelar monocigótico, se realizó una búsqueda de la información en las bases de datos SciELO y PubMed con la terminología MeSH "Pentalogy of Cantrell", "twin" y en español "Pentalogía de Cantrell" y "gemelar".Conclusión: la PC puede ser sospechada ecográficamente por ectopia cordis y defecto toracoabdominal. La presentación de un caso en un embarazo gemelar es una asociación poco frecuente.
An evaluation on instructional systems design
Authors: Uzunboylu Huseyin , Kosucu Emine 
Published: February 2020

Instructional design and instructional systems design concepts different from the direction of the field lead to confusion as it includes similar use cases from time to time. Instructional design models have different characteristics, and in different areas, in line with the needs of nature according to the purpose of alternating the use of different models, it affects the efficiency. Each model is developed that fixing the underlying spots is the best way to a need for designs designed which varies depending on the model. Some models of the objectives underlying the selection and use of different models have the highest level while improving strategies constitute a more important structure. With this assessment, the instructional design, instructional systems design, systems approach and instructional system design models, by examining the historical development of these models and their distinctive features, will be explained in connection with curriculum development. Thus, referring to the different points of each model and specific model, with respect to instructional systems design, the difference in instructional design, space and design process is studied.
Keywords: Instructional systems design, instructional design, instructional design models.
Konstruksi Makna Informasi Risiko Penyakit bagi Penyandang Filariasis
Authors: Purwanti Hadisiwi 
Published: February 2020

Informasi mengenai filariasis adalah bagian dari komunikasi risiko kesehatan yang dapat berdampak negatif jika tidak dikelola sesuai dengan prinsip-prinsip komunikasi risiko yaitu, interaktif, melibatkan pihak-pihak lain yang kredibel, akurat, jujur, dengan penjelasan yang ilmiah. Penelitian menggunakan metode kualitatif dengan pendekatan fenomenologi ini bertujuan untuk mengetahui makna informasi filariasis dari berbagai sumber, yang dikonstruksi oleh penyandang filariasis di Kabupaten Bandung. Melalui informan penelitian yang berjumlah 10 penyandang filariasis yang ditentukan secara purposif, terungkap bahwa informasi yang disampaikan langsung oleh dokter di Puskesmas dengan data dan gambar yang jelas, dimaknai dengan terpercaya, sedangkan informasi yang searah, penyebutan nama penyakit yang tidak akurat tidak menyebutkan nama penyakit, dimaknai sebagai membingungkan.
IDENTIFIKASI KONDISI TERUMBU KARANG PERAIRAN BAGIAN SELATAN PULAU SEPANJANG, KABUPATEN SUMENEP DENGAN MENGGUNAKAN CITRA LANDSAT 8
Authors: Mataburu Ilham B 
Published: February 2020

ABSTRAK
Penelitian ini bertujuan untuk mengenai bagaimana sebaran dan kondisi terumbu karang dengan mengunakan citra landsat 8. Lokasi peneltian dilakukan di perairan sekitar Pulau Sepanjang, Kecamatan Sapeken Kabupaten Sumenep. Penelitian ini mengunakan metode deskriptif kuantitatif dengan menggunakan persamaan Lyzenga dan diterapkan pada Citra Landsat 8 dan dilakukan verifikasi lapangan. Hasil penelitian menunjukan bahwa perbedaan antara hasil pengamatan lapangan dengan hasil analisis mencapai 37,5 % perbedaan ini dijadikan sebagai dasar untuk melakukan koreksi pada citra untuk menghasilkan citra yang lebih tepat. Dan secara umum penggunaan persamaan/algoritma lyzenga pada landsat 8 bisa digunakan untuk mendeteksi kondisi umum terumbu karang khususnya untuk mendeteksi terumbu karang hidup dan mati, sebagai langkah awal untuk mengidentifikasi kualitas terumbu karang.
Kata Kunci : Terumbu karang, Lyzenga, Citra Landsat 8
ANALISIS KONDISI LAMUN (SEAGRASS) DI PERAIRAN PULAU PRAMUKA, KEPULAUAN SERIBU
Authors: Fajarwati Septi Dwi , Setianingsih Asma Irma , Muzani Muzani 
Published: February 2020

ABSTRACT
This research aims to analyze the condition of seagrass ecosystem to see water quality data of the seagrass habitat and percentage cover of seagrass in the waters of the Pramuka Island, Seribu Islands. The research was conducted over two months from October to November 2014.This research used a descriptive method with field survey approach. The population in this study is the seagrass in Waters Pramuka Island. Determining the location with purposive sampling of the sampling is divided into three stations is North, East and South. Data collection techniques include primary data and secondary data. Primary data is data of seagrass (type, percentage cover and density of seagrass) and data of seagrass habitat environmental parameters (water temperature, current speed, brightness, depth, salinity, substrate, TSS, DO, pH) were obtained by direct measurement in the field, while secondary data include the general state of the research sites. Data analysis techniques used in this study using analysis of community structure of seagrass and water quality analysis. The results showed that seagrass species found in the Pramuka Island there are 6 types of seagrass Cymodocea rotundata, Cymodocea serrulata, Enhalus acoroides, Halophila ovalis, Halodule uninervis, Thalassia hemprichii. Conditions of seagrass in the waters of the Pramuka Island included into the category of less healthy-poor seagrass. At station 1 percentage by 31% classified seagrass less healthy conditions, while the other two stations are stations 2 and 3 belong to the category of the poor condition of seagrass, with each percentage cover of seagrass 19.4% and 20.3%. Of all water quality parameters measured, all the parameters are still in normal circumstances, but there are some parameters whose value is high at some stations TSS and pH value is high at station 2 with a value of TSS 18 mg/l and a pH value of 8.2. Water quality and seagrass communities in station 1 is still in good condition for the growth of seagrass, because at this station is an unspoiled area away from human activity, while the stations 2 and 3 have undergone changes in community structure of seagrass because at this station has several anthropogenic activities that disrupt the lives of seagrass, mostly from human activities such as domestic sewage and hoarding/reclamation, which affects the condition of seagrass at station 2 and 3 are poor seagrass.
Keyword: Seagrass, Water Quality, Pramuka Island
MONITORING DAN EVALUASI LOKASI PENYELAMAN PULAU BUNAKEN TAMAN NASIONAL BUNAKEN KOTA MANADO PROVINSI SULAWESI UTARA
Authors: Luasunaung Alfret , Manoppo Victoria , Schaduw Joshian N.W. 
Published: February 2020

ABSTRAK
Penelitian ini bertujuan untuk menganalisis status ekologi daerah penyelaman (dive spot) serta merumuskan strategi yang cocok untuk pengelolaan dan upaya pelestarian terumbu karang, ikan karang dan biota laut secara berkelanjutan pada kawasan penyelaman di perairan Pulau Bunaken. Metode yang digunakan adalah teknik LIT (Line Intercept Transect), dan menganalisis persentase total tutupan karang menggunakan formulasi Gomez and Yap (1978). Hasil [penelitian menunjukkan bahwa secara umum kondisi lokasi penyelaman di Pulau Bunaken masih dalam kategori baik, akan tetapi terdapat indikator menurunnya kualitas terumbu karang dari tahun ke tahun, serta meningkatnya sampah yang masuk ke perairan Pulau Bunaken. Kata kunci : Evaluasi; Monitoring; Terumbu Karang; Bunaken
DEGRADASI HUTAN PULAU YAMDENA di PROVINSI MALUKU TAHUN 1998 â€“ 2008
Authors: Rosantika Agus 
Published: February 2020

ABSTRAK
Hutan tropika basah di Pulau Yamdena Kabupaten Maluku Tenggara Barat memiliki potensi untuk dieksploitasi demi memenuhi kebutuhan kayu masyarakat sekaligus menghasilkan devisa negara. Namun di sisi lain isu degradasi hutan di wilayah ini mengundang perhatian untuk dicermati dan ditelaah. Penelitian ini bertujuan menginformasikan kembali tingkat degradasi hutan di Pulau Yamdena. Hasil penelitian menunjukkan bahwa degradasi hutan di Pulau Yamdena dari tahun 1998 sampai 2008 terjadi sebanyak kurang lebih 9.473 ha/tahun. Hasil analisa juga menunjukkan bahwa tingkat degradasi hutan justru lebih tinggi pada areal di luar kawasan konsesi eks IUPHHK-HA (Ijin Usaha Pemanfaatan Hasil Hutan kayu pada hutan Alam(dahulu disebut HPH)) dibanding di areal dalam kawasan konsesi eks IUPHHK-HA. Dengan demikian disimpulkan bahwa degradasi hutan di Pulau Yamdena terjadi disebabkan oleh aktifitas diluar eksploitasi IUPHHK-HA. Kata Kunci : Degradasi hutan, Yamdena Maluku Tenggara Barat.
Sebaran Lokasi Potensial Minimarket (Alfamart dan Indomaret) Di Kecamatan Babelan
Authors: DIANA NIDA , NUGRATAMA SONY , Adrian Adrian 
Published: February 2020

District Babelan has many minimarkets in the form of Alfamart and Indomaret. Minimarket in District Babelan amounted to 43 minimarket. Minimarkets are scattered in several villages in Babelan sub-district, namely Bahagia village, Kebalen village, Babelan Kota village, Kedung Pengawas village, Kedung Jaya village and Muarabakti village.
The purpose of this study is to see the development of Alfamart and Indomaret, knowing the pattern of distribution as well as potential location of minimarket establishment. The method used in this research is quantitative descriptive analysis with survey approach. Methods of data analysis using stop-point analysis. Data collection using observation techniques by taking data on location and documentation.
The results of this study indicate that the development of Alfamart and Indomaret in the District of Babelan experienced rapid development from 2013-2017. In 2013 in Babelan sub-district there are only 12 minimarkets and by 2017 it has increased to 43 minimarkets, which indicates that minimarket developments in Babelan Sub-district have progressed over time. Next, the pattern of distribution Alfamart and Indomaret in District Babelan has a pattern of clumping. Other than that, the determination of potential location of minimarket establishment is needed to know where the potential position to establish minimarket. The potential distance of minimarket between villages in Babelan sub-district is not much different. The average potential distance of minimarket between villages is 1,4 km.
Keywods : Minimarket, distribution pattern potential location, District of Babelan
KAJIAN PENGGUNAAN METODE IP, STORET, dan CCME WQI DALAM MENENTUKAN STATUS KUALITAS AIR
Authors: ROMDANIA YUDA , Herison Ahmad , Susilo Gatot Eko , Novilyansa Elza 
Published: February 2020

Air kebutuhan makhluk hidup yang utama dalam kehidupan sehari-hari. Pemantauan kualitas air perlu dilakukan pada air sungai, air laut, air danau, air rawa dan air tanah sehingga air dapat dimanfaatkan sesuai dengan kegunaannya. Kajian ini bertujuan untuk menganalisa penggunaan metode perhitungan indeks kualitas air dalam menentukan status kualitas air permukaan sehingga diketahui metode yang paling efektif, sensistif dan obyektif. Metode perhitungan Indeks Kualitas Air (IKA) diperlukan untuk menyederhanakan banyaknya nilai dari berbagai jenis parameter menjadi sebuah angka tunggal yang mampu mendeskripsikan kondisi kualitas air, sehingga lebih mudah dipahami oleh masyarakat. Ada beberapa metode perhitungan IKA di berbagai Negara, metode Storet, IP, dan CCME WQI (Canadian Council of Ministers of The Environment). Metode tersebut akan dibandingkan dengan beberapa indikator. Hasil kajian menunjukkan Metode IP lebih unggul jika memakai data tunggal, karena memiliki kelebihan dari segi biaya dan waktu namun hanya mempresentasikan status mutu air pada saat itu saja tidak dalam periode tertentu. Metode Storet dan CCME menggunakan data perulangan sepanjang waktu (time series data), sehingga lebih menggambarkan status mutu air dalam periode tertentu. CCME WQI lebih unggul dari Metode Storet dan Metode IP karena memperhitungkan besarnya selisih hasil pengujian yang melebihi baku mutu melalui F3 (Amplitude). Dari kajian di atas disimpulkan, Metode CCME merupakan metode yang paling tepat untuk menganalisis kualitas air di berbagai negara termasuk Indonesia baik pada air permukaan maupun air tanah dengan tingkat efektivitas dan sensitivitas yang lebih tinggi dibandingkan dengan metode lainnya serta penggunaan jumlah dan jenis parameter yang fleksibel.
Kata kunci : Kualitas Air, Indeks Kualitas Air, Air Permukaan