bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gallo-Roman Terracottas at the Musée archéologique de l’Oise
Authors: Bossard Adrien 
Published: September 2020

Eighty terracotta figurines from the 2013 discovery at Vendeuil-Caply are exhibited for the first time in the Musée archéologique de l’Oise, located near the archaeological site of Vendeuil-Caply. This exhibition Figures de la terre (fig. 1), which runs until November 2015, is the result of a collaboration with 11 French museums and presents in total more than 100 objects that explore the typological variety and the aesthetic character of the Gallo-Roman figurines of northern Gaul. Included in the exhibition is Marchande de statuettes à Pompéi,1 a 19th-century painting by the neo-classical painter Henry-Pierre Picou that effectively illustrates a commercial context for Roman figurines.
Eagle Syndrome- An Entity Often Misdiagnosed
Authors: Nayak Puneeth S , Harugop Anil Kumar S , Debnath Paramita , Patil Prashant H 
Published: September 2020

Introduction
Throat pain is one of the most common complaints that an otolaryngologist encounters in daily practice, there can be numerous aetiologies to it. Eagle Syndrome is one such entity which is characterized by chronic throat pain due to elongation of the styloid process or mineralization of the stylohyoid ligament. The vague symptomatology of this condition often leads to delayed diagnosis and treatment.

Case Reports
We report 5 cases of Eagle Syndrome. All the patients presented to us with complaints of chronic throat radiating to neck which did not relieve on taking medications, for the same they have been consulting multiple specialities. The diagnosis of Eagle Syndrome was confirmed by palpation in tonsillar fossa and orthopantomogram revealed enlarged styloid process measuring more than 30mm. Upon confirmation, all the 5 patients underwent tonsillo-styloidectomy and on consequent follow ups, they were symptomatically improved.
Discussion
Eagle Syndrome is a diagnosis of exclusion and should raise high index of suspicion in patients with nonspecific throat and neck pain not responding to any conservative treatment. With an increasing incidence of side effects following injudicious treatment given in such cases, this condition requires attention, as it a rare entity and often misdiagnosed.
Adeno‐associated virus serotype 1‐based gene therapy for FTD caused by GRN mutations
Authors: Hinderer Christian , Miller Rod , Dyer Cecilia , Johansson Julia , Bell Peter , Buza Elizabeth , Wilson James M. 
Published: September 2020

AbstractObjectiveDominant loss‐of‐function mutations in the gene encoding the lysosomal protein, progranulin, cause 5‐10% of frontotemporal dementia cases. As progranulin undergoes secretion and endocytosis, a small number of progranulin‐expressing cells can potentially supply the protein to the entire central nervous system. Thus, gene therapy is a promising treatment approach.MethodsWe evaluated adeno‐associated viral vector administration into the cerebrospinal fluid as a minimally invasive approach to deliver the granulin gene to the central nervous system in a murine disease model and nonhuman primates.ResultsIn progranulin‐deficient mice, vector delivery into the lateral cerebral ventricles increased progranulin levels in the cerebrospinal fluid and normalized histological and biochemical markers of progranulin deficiency. A single vector injection into the cisterna magna of nonhuman primates achieved CSF progranulin concentrations up to 40‐fold higher than those of normal human subjects and exceeded CSF progranulin levels of successfully treated mice. Animals treated with an adeno‐associated virus serotype 1 vector exhibited progranulin expression fivefold higher than those treated with an AAV5 vector or the AAV9 variant, AAVhu68, apparently due to remarkably efficient transduction of ependymal cells. Progranulin expression mediated by adeno‐associated viral vectors was well tolerated in nonhuman primates with no evidence of dose‐limiting toxicity, even at vector doses that induced supraphysiologic progranulin expression.InterpretationThese findings support the development of AAV1‐based gene therapy for frontotemporal dementia caused by progranulin deficiency.
Positive Psychological Factors and Impairment in Rheumatic and Musculoskeletal Disease: Do Psychopathology and Sleep Quality Explain the Linkage?
Authors: Hirsch Jameson K. , Altier Heather R. , Offenbächer Martin , Toussaint Loren , Kohls Niko , Sirois Fuschia M. 
Published: September 2020

ObjectiveLittle is known about potential mechanisms of action linking protective positive psychological variables and functional disability in patients with rheumatic and musculoskeletal disease. The present study was undertaken to examine symptoms of psychopathology, including stress, depression, anxiety, and sleep quality, as serial mediators of the association between gratitude, self‐compassion, self‐forgiveness, and functional impairment.MethodsWe assessed risk and protective factors for functional disability in patients with fibromyalgia (FM), osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) who were recruited from an Austrian health care facility. Respondents completed online surveys, including the Gratitude Questionnaire 6‐item form, the Self‐Compassion Scale short form, the Self‐Forgiveness and Forgiveness of Others Index, the Perceived Stress Scale 4, the Patient Health Questionnaire 2, the 2‐item Generalized Anxiety Disorder Scale, the Sleep Condition Indicator, and the Health Assessment Questionnaire. Bivariate and serial mediation analyses were conducted.ResultsFor our sample of 1,218 patients (52% female, n = 632; AS [37%], OA [34%], RA [14%], and FM [24%]), stress, depression, and anxiety, in parallel as first‐order mediators, and sleep quality as a second‐order mediator, explained the association between positive psychological variables and functional disability.ConclusionPositive psychological factors exert a beneficial downstream effect on mental well‐being, sleep health, and health‐related functional impairment. Therapeutic promotion of gratitude, self‐compassion, and self‐forgiveness may improve mental and physical health in patients with rheumatic and musculoskeletal disease.
Performance and Predictors of Minimal Disease Activity Response in Patients With Peripheral Spondyloarthritis Treated With Adalimumab
Authors: Coates Laura C. , Abraham Sonya , Tillett William , Mease Philip J. , Ramiro Sofia , Wu Tianshuang , Wang Xin , Pangan Aileen L. , Song In‐Ho 
Published: September 2020

ObjectiveTo examine the concurrent validity and discrimination of criteria for modified minimal disease activity (MDA) in peripheral spondyloarthritis (SpA) following filter principles of Outcome Measures in Rheumatology (OMERACT) and to determine predictors of modified MDA response.MethodsFour modified MDA versions were derived in the ABILITY‐2 study using the Spondyloarthritis Research Consortium of Canada (SPARCC) enthesitis index or the Leeds Enthesitis Index (LEI) while excluding psoriasis. To assess concurrent validity, modified MDA versions were correlated with Peripheral Spondyloarthritis Response Criteria (PSpARC) remission, Ankylosing Spondylitis Disease Activity Score showing inactive disease (ASDAS ID), and physician global assessment of disease activity. Treatment discrimination was assessed between adalimumab and placebo at week 12. Multiple logistic regression was used to determine baseline predictors of long‐term modified MDA responses and sustained modified MDA.ResultsThe 4 modified MDA versions showed a stronger positive correlation with PSpARC remission (rtet > 0.95) versus ASDAS ID (rtet > 0.75) at week 12 and years 1–3 and were able to show discrimination (P < 0.001). Responsiveness was shown at week 12; significantly more patients receiving adalimumab versus placebo achieved all 4 versions of modified MDA. Approximately 40–60% of patients treated with adalimumab achieved modified MDA using the LEI or SPARCC enthesitis index at years 1–3. Achieving modified MDA response after 12 weeks of adalimumab treatment was a robust positive predictor of attaining long‐term modified MDA through 3 years (odds ratio [OR] 11.38–27.13 for modified MDA using the LEI; OR 17.98–37.85 for modified MDA using the SPARCC enthesitis index).ConclusionAll 4 versions of modified MDA showed concurrent validity and discriminated well between adalimumab and placebo treatment groups. Early modified MDA response is a more consistent predictor of long‐term modified MDA achievement than baseline characteristics. The 5 of 6 versions of modified MDA could be an appropriate treatment target in patients with peripheral SpA.
Inflammation of the Sacroiliac Joints and Spine and Structural Changes on Magnetic Resonance Imaging in Axial Spondyloarthritis: Five‐Year Data From the DESIR Cohort
Authors: Sepriano Alexandre , Ramiro Sofia , Landewé Robert , Moltó Anna , Claudepierre Pascal , Wendling Daniel , Dougados Maxime , van der Heijde Désirée 
Published: September 2020

ObjectiveTo test the impact of inflammation on structural changes occurring in the sacroiliac (SI) joints and the spine detected on magnetic resonance imaging (MRI).MethodsPatients with early axial spondyloarthritis (SpA) from the Devenir des Spondylarthropathies Indifferérenciées Récentes (DESIR) cohort were included. MRIs of the SI joints (MRI‐SI joints) and spine (MRI‐spine), obtained at baseline, 2 years, and 5 years, were scored by 3 central readers. Inflammation and structural damage on MRI‐SI joints and MRI‐spine were defined by the agreement of ≥2 of 3 readers (binary outcomes) and by the average of 3 readers (continuous outcomes). The effect of inflammation (MRI‐SI joints/MRI‐spine) on damage (MRI‐SI joints/MRI‐spine, respectively) was evaluated in 2 models: 1) a baseline prediction model (the effect of baseline inflammation on damage assessed at 5 years); and 2) a longitudinal model (the effect of inflammation on structural damage assessed during a 5‐year period).ResultsA total of 202 patients were included. Both the presence of bone marrow edema on MRI‐SI joints and on MRI‐spine at baseline were predictive of 5‐year damage (≥3 fatty lesions) on MRI‐SI joints (odds ratio [OR] 4.2 [95% confidence interval (95% CI) 2.4, 7.3]) and MRI‐spine (OR 10.7 [95% CI 2.4, 49.0]), respectively, when adjusted for C‐reactive protein level. The association was also confirmed in longitudinal models (when adjusted for Ankylosing Spondylitis Disease Activity Score) both in the SI joints (OR 5.1 [95% CI 2.7, 9.6]) and spine (OR 15.6 [95% CI 4.8, 50.3]). Analysis of other structural outcomes (i.e., erosions) on MRI‐SI joints yielded similar results. In the spine, a significant association was found for fatty lesions but not for erosions and bone spurs, which occurred infrequently over time.ConclusionWe found a predictive and longitudinal association between inflammation detected on MRI and several types of structural damage detected on MRI in patients with early axial SpA, which adds to the evidence for a causal relationship.
Collective Transport of Magnetic Microparticles at a Fluid Interface through Dynamic Self‐Assembled Lattices
Authors: Martínez‐Pedrero Fernando , Ortega Francisco , Rubio Ramón G. , Calero Carles 
Published: September 2020

AbstractThe transport of confined micron‐sized particles plays an important role in a range of phenomena in biology, colloidal science, and solid‐state physics. Here, an easily implementable strategy that allows for the collective and monitored transport of magnetic colloidal particles along fluid–fluid interfaces is introduced. Adsorbed microparticles are carried on time‐dependent magnetic potentials, generated by dynamic self‐assembled lattices of different‐sized particles confined onto a parallel plane. In such binary system, the synchronized inversion of the precessing applied field allows for the ballistic and directional transport of the motile components along prescribed directions. The transportation mode can be tuned through the stoichiometry or the strength and orientation of the applied field. The described methodology can be used in the capture and manipulation of drugs or pollutants adsorbed on liquid surfaces, the segregation of colloidal mixtures or the assisted mixture of surface active molecules.
Permanent Electrochemical Doping of Quantum Dots and Semiconductor Polymers
Authors: Gudjonsdottir Solrun , Houtepen Arjan J. 
Published: September 2020

AbstractArguably the most controllable way to control the charge density in various semiconductors, is by electrochemical doping. However, electrochemically injected charges usually disappear within minutes to hours, which is why this technique is not yet used to make semiconductor devices. In this manuscript, electrochemical doping of different semiconductor films (ZnO Quantum Dots (QDs), PbS QDs, and P3DT) is investigated in various high melting‐point nitrile‐based solvents. It is shown that by charging the semiconductors at elevated temperatures, then cooling down to room temperature where these solvents are frozen, the doping stability increases immensely. Measurements performed in cyanoacetamide show that ion transport is entirely halted at room temperature, and that the n‐type conductivity is stable for days, and only drops marginally (≈10%) in several weeks. For p‐doped P3DT films, the conductivity is even completely stable during the entire 76 days of the measurement. In an ambient atmosphere, the p‐type doping is stable, while the n‐type doping disappears in several hours, as electrons react with molecular oxygen. Finally, a pn‐junction diode made of a PbS QD film is demonstrated. These results highlight the possibility of using solidified electrolytes for electrochemical doping and for obtaining semiconductor devices wherein the doping density is controlled electrochemically.
Coating of a Novel Antimicrobial Nanoparticle with a Macrophage Membrane for the Selective Entry into Infected Macrophages and Killing of Intracellular Staphylococci
Authors: Li Yuanfeng , Liu Yong , Ren Yijin , Su Linzhu , Li Ang , An Yingli , Rotello Vincent , Zhang Zhanzhan , Wang Yin , Liu Yang , Liu Sidi , Liu Jian , Laman Jon D. , Shi Linqi , van der Mei Henny C. , Busscher Henk J. 
Published: September 2020

AbstractInternalization of Staphylococcus aureus by macrophages can inactivate bacterial killing mechanisms, allowing intracellular residence and dissemination of infection. Concurrently, these staphylococci can evade antibiotics that are frequently unable to pass mammalian cell membranes. A binary, amphiphilic conjugate composed of triclosan and ciprofloxacin is synthesized that self‐assemble through micelle formation into antimicrobial nanoparticles (ANPs). These novel ANPs are stabilized through encapsulation in macrophage membranes, providing membrane‐encapsulated, antimicrobial‐conjugated NPs (Me‐ANPs) with similar protein activity, Toll‐like receptor expression and negative surface charge as their precursor murine macrophage/human monocyte cell lines. The combination of Toll‐like receptors and negative surface charge allows uptake of Me‐ANPs by infected macrophages/monocytes through positively charged, lysozyme‐rich membrane scars created during staphylococcal engulfment. Me‐ANPs are not engulfed by more negatively charged sterile cells possessing less lysozyme at their surface. The Me‐ANPs kill staphylococci internalized in macrophages in vitro. Me‐ANPs likewise kill staphylococci more effectively than ANPs without membrane‐encapsulation or clinically used ciprofloxacin in a mouse peritoneal infection model. Similarly, organ infections in mice created by dissemination of infected macrophages through circulation in the blood are better eradicated by Me‐ANPs than by ciprofloxacin. These unique antimicrobial properties of macrophage‐monocyte Me‐ANPs provide a promising direction for human clinical application to combat persistent infections.
Biodegradable Untethered Magnetic Hydrogel Milli‐Grippers
Authors: Goudu Sandhya Rani , Yasa Immihan Ceren , Hu Xinghao , Ceylan Hakan , Hu Wenqi , Sitti Metin 
Published: September 2020

AbstractSmall‐scale magnetic soft‐bodied robots based on biocompatible and biodegradable materials are essential for their potential high‐impact minimally invasive medical applications inside the human body. Therefore, a strategy for fully biodegradable untethered soft millirobots with encoded 3D magnetic anisotropy for their static or dynamic shape programming is presented. Such a robot body is comprised of a porcine extracellular matrix‐derived collagen‐based hydrogel network with embedded superparamagnetic iron oxide nanoparticles (SPIONs). 3D magnetization programming inside the hydrogel body is achieved by directionally self‐assembled SPION chains using an external permanent magnet. As a proof‐of‐concept demonstration, a hydrogel milli‐gripper that can undergo flexible and reversible shape deformations inside glycerol and biologically relevant liquid media is presented. The gripper can perform cargo grabbing, transportation by rolling, and release by controlling magnetic field inputs. These milli‐grippers can be completely degraded by the matrix metalloproteinase‐2 enzyme in physiologically relevant concentrations. Furthermore, biocompatibility tests using human umbilical cord vein endothelial cells with the degradation products of the grippers demonstrate no acute toxicity. The approach offers a facile fabrication strategy for designing biocompatible and biodegradable soft robots using nanocomposite materials with programmable 3D magnetic anisotropy toward future medical applications.
Piezocatalysis and Piezo‐Photocatalysis: Catalysts Classification and Modification Strategy, Reaction Mechanism, and Practical Application
Authors: Tu Shuchen , Guo Yuxi , Zhang Yihe , Hu Cheng , Zhang Tierui , Ma Tianyi , Huang Hongwei 
Published: September 2020

AbstractPiezoelectric‐based catalysis that relies on the charge energy or separation efficiency of charge carriers has attracted significant attention. The piezo‐potential induced by strain or stress can induce a giant electric field, which has been demonstrated to be an effective means for charge energy shifting or transferring electrons and holes. In recent years, intense efforts have been made in this subject, and the research has mainly focussed on two aspects: i) Alteration of surface charge energy by piezo‐potential in piezocatalysis; ii) the separation of photo‐generated charge carriers and the catalytic activity enhancement of an integrated piezoelectric semiconductor or coupled system composed of piezoelectrics and semiconductors. Systematically summarizing the advances of the above two aspects is helpful in the context of deepening understanding of the relevant issues and developing new ideas for piezoelectric‐based catalysis. In this review, a comprehensive summary on piezocatalysis and piezo‐photocatalysis is provided. The charge transfer behaviors and catalytic mechanisms over a large variety of piezocatalysts and piezo‐photocatalysts are systematically analyzed. In addition, the types of mechanical energy, strategies for enhancing piezocatalysis, and the advanced applications of piezocatalysis and piezo‐photocatalysis are discussed. Finally, the promising development directions of piezocatalysis and piezo‐photocatalysis, such as materials, assembly forms, and applications in the future are proposed.
Observation of Strong Bulk Damping‐Like Spin‐Orbit Torque in Chemically Disordered Ferromagnetic Single Layers
Authors: Zhu Lijun , Zhang Xiyue S. , Muller David A. , Ralph Daniel C. , Buhrman Robert A. 
Published: September 2020

AbstractStrong damping‐like spin‐orbit torque (τDL) has great potential for enabling ultrafast energy‐efficient magnetic memories, oscillators, and logic. So far, the reported τDL exerted on a thin‐film magnet must result from an externally generated spin current or from an internal non‐equilibrium spin polarization in non‐centrosymmetric GaMnAs single crystals. Here, for the first time a very strong, unexpected τDL is demonstrated from current flow within ferromagnetic single layers of chemically disordered, face‐centered‐cubic CoPt. It is established here that the novel τDL is a bulk effect, with the strength per unit current density increasing monotonically with the CoPt thickness, and is insensitive to the presence or absence of spin sinks at the CoPt surfaces. This τDL most likely arises from a net transverse spin polarization associated with a strong spin Hall effect, while there is no detectable long‐range asymmetry in the material. These results broaden the scope of spin‐orbitronics and provide a novel avenue for developing single‐layer‐based spin‐torque memory, oscillator, and logic technologies.
Recent Advances of Synthesis, Properties, Film Fabrication Methods, Modifications of Poly(3,4‐ethylenedioxythiophene), and Applications in Solution‐Processed Photovoltaics
Authors: Jiang Youyu , Liu Tiefeng , Zhou Yinhua 
Published: September 2020

AbstractPoly(3,4‐ethylenedioxythiophene) (PEDOT) is a very unique polymer. It can be very conductive, highly transparent, and environmentally stable. It is highly switchable between its oxidation state and neutral state. It forms a micellar complex with polystyrene sulfonate in aqueous conditions, and then can be solution‐processible and printable. Based on these advantages, PEDOT has been widely used as conductors and transparent electrodes in electronics and optoelectronics. The device performance is highly correlated with the structure and properties of PEDOT. In this review, advances in the synthesis, optoelectronic and chemical properties are comprehensively described and analyzed, as well as the strategies for tuning these properties to fulfill the requirement for device applications. Film processing techniques (printing and transfer printing) for the conducting polymer are also presented. Then, the applications of PEDOT as conductors for versatile organic and perovskite solar cells (single‐junction, tandem, semitransparent, colorful, flexible and ultraflexible, fully printed solar cells) are summarized. Finally future study directions for PEDOT in terms of conductivity enhancement and application‐oriented formulations are discussed.
Nanoconfined Water‐Molecule Channels for High‐Yield Solar Vapor Generation under Weaker Sunlight
Authors: Lu Qichen , Shi Wenxiong , Yang Haozhou , Wang Xun 
Published: September 2020

AbstractSolar vapor generation is a promising method to efficiently produce fresh water. However, the insufficient vapor yields under natural daylight restrict its practical applications, and the basic evaporation mechanisms are deficient for reasonable design of evaporator structure. Here, hydrophobic nano‐confined water molecule channels (NCWMCs) are demonstrated, which can reduce the vaporization enthalpy for water evaporation and achieve a record vapor generation rate of 1.25 kg m−2 h−1 under 0.5 sun irradiation. Molecular dynamics simulations reveal the cluster‐evaporation process in the NCWMC system. As a result, the evaporator with NCWMC system can effectively purify seawater and wastewater samples using this environmentally friendly strategy.
Iron‐Catalyzed Intermolecular Functionalization of Non‐Activated Aliphatic C−H Bonds via Carbene Transfer
Authors: Rodríguez Mònica , Font Gemma , Nadal‐Moradell Joel , Hernán‐Gómez Alberto , Costas Miquel 
Published: September 2020

AbstractThe modification of strong Csp3−H bonds via iron carbene intermediates under mild reaction conditions has been an important challenge with attractive prospective in organic synthesis. In this work, we show the efficient combination of an electrophilic iron catalyst with a lithium Lewis acid for the functionalization of strong Csp3−H bonds of cyclic and linear alkanes by the activation of commercially available ethyl diazoacetate (EDA). The reaction proceeds with good yields, under mild reaction conditions (40 °C) and large excess of substrate is not needed. In addition, excellent activity is observed in the cyclopropanation of challenging aliphatic olefins.magnified image