bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer Awareness and Preference towards Finger Millet in Sri Lanka
Authors: Jayawardana Sooriya Arachchige Sachini , Samarawickrama Dineth Suharda , Samarasekera Jayanetti Koralalage Ramani Radhika , Hettiarachchi Gardhi Hettiarachchige Chamari Madhu , Gooneratne Mahavidanage Jaanaki 
Published: October 2020

Aim: This survey was conducted to evaluate Sri Lankans’ awareness and attitudes towards finger millet and preferences towards finger millet-based foods.
Methodology: Pre-tested, self-administrated questionnaires were formulated in the three main languages used in Sri Lanka, namely Sinhala, English and Tamil. The questionnaires consisted of different sections to obtain data on respondents’ socio-demographic characteristics, health and food related lifestyles, attitudes towards finger millet and preferences towards finger millet-based food products. Printed and online forms were distributed covering all 25 districts from August to November in 2017 and after excluding incomplete responses 1016 respondents were selected for the study. Data were analyzed using Frequency analysis and Chi-square analysis.
Results: Although the majority of the respondents (57.5%) were aware of the nutritional value of finger millet, a considerable percentage of the respondents have stated that they are not aware of the nutritional value. The majority of the respondents who were suffering from non-communicable diseases rarely added finger millet to their diets. The majority of the respondents (66.6%) liked to consume finger millet regardless of gender, age, educational level and residing district. However, limited availability of finger millet flour incorporated food products in ready-to-eat form has restricted their regular finger millet consumption. Only 33.9% of the respondents were aware of the finger millet flour incorporated food products currently available in the local market. The majority of the respondents wished to purchase finger millet flour incorporated novel ready-to-eat products to increase their finger millet consumption.
Conclusion: The findings evidently indicated the importance of educating the general public on nutritional value and various health benefits of finger millet. Further, the findings revealed the necessity of effective advertising and promoting approaches for the finger millet flour incorporated products currently available in the local market and reflected market opportunities for novel finger millet flour incorporated ready-to-eat products.
Pathways to Care for Children with Mental Disorders and Epilepsy Attending Specialist Clinics in Nigeria
Authors: Awusah Tolulope Bella – , Adebayo Adeola , Lagunju Ikeoluwa , Omigbodun Olayinka 
Published: October 2020

Aims: This study set out to identify and compare the pathways to care for children and adolescents presenting at child psychiatry and paediatric neurology clinics in South West Nigeria.
Study Design: This was a comparative cross sectional study.
Place and Duration of Study: Departments of Child and Adolescent Psychiatry and Paediatrics, University College Hospital Ibadan, Nigeria between February and May 2017.
Methodology: A sociodemographic questionnaire and the World Health Organization’s (WHO) pathway encounter form were used to assess 114 participants (57 in each group) recruited sequentially into the study. Kaplan meier survival analysis was used to compare time to seeking orthodox and specialist care between the two groups, and Atlas Ti software was used to analyse qualitative responses about barriers to accessing care.
Results: There were slightly more males than females in both groups, and the mean age of participants was 9.87 years (SD =5.52). Participants in the paediatric neurology group were significantly more likely to access orthodox care at their first level of contact than their child psychiatry counterparts {41 (71.93%) vs. 18 (31.58%); P.<0.001}. There were significant differences in the median survival time to accessing orthodox medical care between the two groups: {paediatric neurology 8 weeks (IQR =23.79) vs. child psychiatry 192 weeks (IQR =80; P < 0.001}. There was however no siginificant difference in median survival time to specialist care between the two groups. Lack of finances, frequently having to take time off work, and long distances to the hospital were the major barriers to accessing orthodox medical care in both groups.
Conclusions: Our findings suggest a need for continous advocacy to promote better access to orthodox healthcare for youths with psychiatric and neurological disorders in the developing world context.
Outcomes of Pancreatic Resection for Elderly Patients With Pancreatic Cancer
Authors: Suzuki Shuji , Shimoda Mitsugi , Shimazaki Jiro , Oshiro Yukio , Nishida Kiyotaka , Sahara Yatsuka , Nagakawa Yuichi , Tsuchida Akihiko 
Published: October 2020

Background
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor, albeit gradually improving, prognosis. We evaluated the predictive clinicophysiologic outcomes of elderly patients with PDAC.

Methods
We retrospectively examined 260 patients who underwent pancreatic resection classified into 2 groups: (A) those who were ≤80 years of age (B) and those who were &gt;80 years of age. Operative characteristics, preoperative clinicophysiologic parameters (body mass index, jaundice decompression, total bilirubin, albumin [Alb], creatinine, hemoglobin A1c, amylase, C-reactive protein [CRP], white blood cells, lymphocytes, hemoglobin, platelets, cancer antigen 19-9, carcinoembryonic antigen, neutrophil/lymphocyte ratio, prognostic nutritional index, platelet/lymphocyte ratio, and CRP/Alb ratio), disease-free survival (DFS), and overall survival (OS) were reported.

Results
There were no differences in morbidity, mortality, and preoperative clinicophysiologic parameters between the groups. Median DFS of groups A and B were 15.4 and 15.5 months, respectively. One-year/3-year OS of groups A and B were 86.7%/68% and 88.4%/69.3%, respectively. There were no differences in DFS and OS between the groups.

Conclusion
Curative resection for PDAC can be safely performed in elderly and younger patients, and elderly patients with PDAC can benefit from curative surgery without a significant decrease in survival rates.
Iniciativas brasileiras em torno da construção de uma Política Nacional para Acervos Digitais de Instituições de Memória: o desafio da memória em tempos de cultura digital
Authors: Dias Calíope Victor Spíndola de Miranda , Martins Dalton Lopes 
Published: October 2020

<p class="Resumo">A partir da compreensão acerca das transformações sociais, consequência das novas possibilidades recorrentes da popularização da internet, percebe-se por parte das instituições de memória a necessidade de reestruturação de seus processos de representação e apropriação cultural. Apresenta-se a ideia de concepção de acervos digitais pela perspectiva do fenômeno rede e aponta como problema de pesquisa que a inexistência de uma política pública nacional para acervos digitais dificulta os processos de acompanhamento de políticas do setor cultural e, sobretudo, a disponibilização de acervos culturais de forma conectada. O trabalho tem como objetivo realizar revisão bibliográfica acerca das iniciativas brasileiras que caminham em direção à construção dessa política para acervos digitais e identifica vertentes em comum entre as iniciativas apresentadas. Como perspectiva metodológica em uma abordagem qualitativa, abrange a pesquisa exploratória e se desenvolve a partir de pesquisa documental e bibliográfica. </p>
Apresentação: Dossiê - Tecnologia e políticas culturais: o acesso à cultura digital no Brasil
Authors: De Almeida Marco Antonio , Maia Elder Patrick 
Published: October 2020

Apresentação do dossiê "Tecnologia e políticas culturais: o acesso à cultura digital no Brasil", que contempla os seguintes artigos: <span><span><span><span lang="EN"><span><span>“Iniciativas brasileiras em torno da construção de uma Política Nacional para Acervos Digitais de Instituições de Memória: o desafio da memória em tempos de cultura digital”; </span></span></span></span></span></span><span><span><span><span lang="EN"><span><span>“As Transformações da Era Digital e o Impacto na Economia da Cultura do Livro”; </span></span></span></span></span></span><span><span><span><span lang="EN"><span><span><span>“Dialogando com e sobre o rural através das novas mídias: estratégias e desafios da comunicação” e </span></span></span></span></span></span></span><span><span><span><span lang="EN"><span><span><span>“Softwares livres e políticas culturais no Brasil: o caso do Mapa Cultural”. Os artigos tratam das aplicações das tecnologias digitais às políticas culturais, localizando-as num contexto mais geral das aplicações das TICs e analisando casos setoriais.</span></span></span></span></span></span></span>
Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models
Authors: Pearce Amanda K. , Anane‐Adjei Akosua B. , Cavanagh Robert J. , Monteiro Patricia F. , Bennett Thomas M. , Taresco Vincenzo , Clarke Phil A. , Ritchie Alison A. , Alexander Morgan R. , Grabowska Anna M. , Alexander Cameron 
Published: October 2020

AbstractThe size, shape, and underlying chemistries of drug delivery particles are key parameters which govern their ultimate performance in vivo. Responsive particles are desirable for triggered drug delivery, achievable through architecture change and biodegradation to control in vivo fate. Here, polymeric materials are synthesized with linear, hyperbranched, star, and micellar‐like architectures based on 2‐hydroxypropyl methacrylamide (HPMA), and the effects of 3D architecture and redox‐responsive biodegradation on biological transport are investigated. Variations in “stealth” behavior between the materials are quantified in vitro and in vivo, whereby reduction‐responsive hyperbranched polymers most successfully avoid accumulation within the liver, and none of the materials target the spleen or lungs. Functionalization of selected architectures with doxorubicin (DOX) demonstrates enhanced efficacy over the free drug in 2D and 3D in vitro models, and enhanced efficacy in vivo in a highly aggressive orthotopic breast cancer model when dosed over schedules accounting for the biodistribution of the carriers. These data show it is possible to direct materials of the same chemistries into different cellular and physiological regions via modulation of their 3D architectures, and thus the work overall provides valuable new insight into how nanoparticle architecture and programmed degradation can be tailored to elicit specific biological responses for drug delivery.
A 3D, Dynamically Loaded Hydrogel Model of the Osteochondral Unit to Study Osteocyte Mechanobiology
Authors: Wilmoth Rachel L. , Ferguson Virginia L. , Bryant Stephanie J. 
Published: October 2020

AbstractOsteocytes are mechanosensitive cells that orchestrate signaling in bone and cartilage across the osteochondral unit. The mechanisms by which osteocytes regulate osteochondral homeostasis and degeneration in response to mechanical cues remain unclear. This study introduces a novel 3D hydrogel bilayer composite designed to support osteocyte differentiation and bone matrix deposition in a bone‐like layer and to recapitulate key aspects of the osteochondral unit's complex loading environment. The bilayer hydrogel is fabricated with a soft cartilage‐like layer overlaying a stiff bone‐like layer. The bone‐like layer contains a stiff 3D‐printed hydrogel structure infilled with a soft, degradable, cellular hydrogel. The IDG‐SW3 cells embedded within the soft hydrogel mature into osteocytes and produce a mineralized collagen matrix. Under dynamic compressive strains, near‐physiological levels of strain are achieved in the bone layer (≤ 0.08%), while the cartilage layer bears the majority of the strains (>99%). Under loading, the model induces an osteocyte response, measured by prostaglandin E2, that is frequency, but not strain, dependent: a finding attributed to altered fluid flow within the composite. Overall, this new hydrogel platform provides a novel approach to study osteocyte mechanobiology in vitro in an osteochondral tissue‐mimetic environment.
Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery
Authors: Rizzo Fabio , Kehr Nermin Seda 
Published: October 2020

AbstractInjectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.
Current Advances on 3D‐Bioprinted Liver Tissue Models
Authors: Ma Liang , Wu Yutong , Li Yuting , Aazmi Abdellah , Zhou Hongzhao , Zhang Bin , Yang Huayong 
Published: October 2020

AbstractThe liver, the largest gland in the human body, plays a key role in metabolism, bile production, detoxification, and water and electrolyte regulation. The toxins or drugs that the gastrointestinal system absorbs reach the liver first before entering the bloodstream. Liver disease is one of the leading causes of death worldwide. Therefore, an in vitro liver tissue model that reproduces the main functions of the liver can be a reliable platform for investigating liver diseases and developing new drugs. In addition, the limitations in traditional, planar monolayer cell cultures and animal tests for evaluating the toxicity and efficacy of drug candidates can be overcome. Currently, the newly emerging 3D bioprinting technologies have the ability to construct in vitro liver tissue models both in static scaffolds and dynamic liver‐on‐chip manners. This review mainly focuses on the construction and applications of liver tissue models based on 3D bioprinting. Special attention is given to 3D bioprinting strategies and bioinks for constructing liver tissue models including the cell sources and hydrogel selection. In addition, the main advantages and limitations and the major challenges and future perspectives are discussed, paving the way for the next generation of in vitro liver tissue models.
Polymeric Nanoparticles Controlled by On‐Chip Self‐Assembly Enhance Cancer Treatment Effectiveness
Authors: Jung Sungjin , Lee Junseok , Lim Junha , Suh Jeeyeon , Kim Taeyoung , Ahn Jungho , Kim Won Jong , Kim YongTae 
Published: October 2020

AbstractNanoparticle (NP)‐based drug delivery systems or nanomedicines have broadened the horizon of translational research for decades. Conventional bulk mixing synthesis methods have impeded successful clinical translations of nanomedicines due to the limited ability of the controlled, scalable production with high uniformity. Herein, an on‐chip preparation of self‐assembled, drug‐encapsulated polymeric NPs is presented for their improved uniformity and homogeneity that results in enhanced anti‐cancer effect in vitro and in vivo. The NPs are formulated through rapid convective mixing of two aqueous solutions of a hydrophilic polymer and an anti‐cancer drug, doxorubicin (DOX), in the swirling microvortex reactor (SMR). Compared to conventional bulk‐mixed NPs (BMPs), the microvortex‐synthesized NPs (MVPs) exhibit narrower size distributions and better size tunability. It is found that the improved uniformity and homogeneity of the MVPs not only enhance cellular uptake and anti‐cancer effect with pH‐responsive drug release in vitro, but also result in an improved tumor regression and decreased side effects at off‐targeted organs in vivo. The findings demonstrate that uniformly designed NPs with more homogeneous properties can induce a significant enhancement of an anti‐cancer effect in vivo. The results show the potential of a high‐speed on‐chip synthesis as a scalable manufacturing platform for reliable clinical translations of nanomedicines.
Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium
Authors: Kokot Hana , Kokot Boštjan , Sebastijanović Aleksandar , Voss Carola , Podlipec Rok , Zawilska Patrycja , Berthing Trine , Ballester‐López Carolina , Danielsen Pernille Høgh , Contini Claudia , Ivanov Mikhail , Krišelj Ana , Čotar Petra , Zhou Qiaoxia , Ponti Jessica , Zhernovkov Vadim , Schneemilch Matthew , Doumandji Zahra , Pušnik Mojca , Umek Polona , Pajk Stane , Joubert Olivier , Schmid Otmar , Urbančič Iztok , Irmler Martin , Beckers Johannes , Lobaskin Vladimir , Halappanavar Sabina , Quirke Nick , Lyubartsev Alexander P. , Vogel Ulla , Koklič Tilen , Stoeger Tobias , Štrancar Janez 
Published: October 2020

AbstractOn a daily basis, people are exposed to a multitude of health‐hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material‐associated diseases, currently hindered due to the lack of in‐depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long‐lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe‐by‐design‐based material development. Because of its profound implications for animal‐free predictive toxicology, this work paves the way to a more efficient and hazard‐free introduction of numerous new advanced materials into our lives.
Magneto‐Driven Gradients of Diamagnetic Objects for Engineering Complex Tissues
Authors: Zlotnick Hannah M. , Clark Andy T. , Gullbrand Sarah E. , Carey James L. , Cheng Xuemei M. , Mauck Robert L. 
Published: October 2020

AbstractEngineering complex tissues represents an extraordinary challenge and, to date, there have been few strategies developed that can easily recapitulate native‐like cell and biofactor gradients in 3D materials. This is true despite the fact that mimicry of these gradients may be essential for the functionality of engineered graft tissues. Here, a non‐traditional magnetics‐based approach is developed to predictably position naturally diamagnetic objects in 3D hydrogels. Rather than magnetizing the objects within the hydrogel, the magnetic susceptibility of the surrounding hydrogel precursor solution is enhanced. In this way, a range of diamagnetic objects (e.g., polystyrene beads, drug delivery microcapsules, and living cells) are patterned in response to a brief exposure to a magnetic field. Upon photo‐crosslinking the hydrogel precursor, object positioning is maintained, and the magnetic contrast agent diffuses out of the hydrogel, supporting long‐term construct viability. This approach is applied to engineer cartilage constructs with a depth‐dependent cellularity mirroring that of native tissue. These are thought to be the first results showing that magnetically unaltered cells can be magneto‐patterned in hydrogels and cultured to generate heterogeneous tissues. This work provides a foundation for the formation of opposing magnetic‐susceptibility‐based gradients within a single continuous material.
Enhanced Four‐Wave Mixing in Silicon Nitride Waveguides Integrated with 2D Layered Graphene Oxide Films
Authors: Qu Yang , Wu Jiayang , Yang Yunyi , Zhang Yuning , Liang Yao , El Dirani Houssein , Crochemore Romain , Demongodin Pierre , Sciancalepore Corrado , Grillet Christian , Monat Christelle , Jia Baohua , Moss David J. 
Published: October 2020

AbstractLayered 2D graphene oxide (GO) films are integrated with silicon nitride (SiN) waveguides to experimentally demonstrate an enhanced Kerr nonlinearity via four‐wave mixing (FWM). SiN waveguides with both uniformly coated and patterned GO films are fabricated based on a transfer‐free, layer‐by‐layer GO coating method along with standard photolithography and lift‐off processes, yielding precise control of the film thickness, placement, and coating length. Detailed FWM measurements are carried out for the fabricated devices with different numbers of GO layers and at different pump powers, achieving up to ≈7.3 dB improvement in the FWM conversion efficiency for an uniformly coated device with one layer of GO and ≈9.1 dB for a patterned device with five layers of GO. A detailed analysis of the influence of pattern length and position on the FWM performance is performed. The dependence of GO's third‐order nonlinearity on layer number and pump power is also extracted, revealing interesting physical insights about the layered 2D GO films. Finally, an enhancement is obtained in the effective nonlinear parameter of the hybrid waveguides by over a factor of 100 relative to bare SiN waveguide. These results demonstrate the high nonlinear optical performance of SiN waveguides integrated with layered 2D GO films.
Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques
Authors: Zhou Xia , Hu Ziwei , Yang Danting , Xie Shouxia , Jiang Zhengjin , Niessner Reinhard , Haisch Christoph , Zhou Haibo , Sun Pinghua 
Published: October 2020

AbstractThe rapid, highly sensitive, and accurate detection of bacteria is the focus of various fields, especially food safety and public health. Surface‐enhanced Raman spectroscopy (SERS), with the advantages of being fast, sensitive, and nondestructive, can be used to directly obtain molecular fingerprint information, as well as for the on‐line qualitative analysis of multicomponent samples. It has therefore become an effective technique for bacterial detection. Within this progress report, advances in the detection of bacteria using SERS and other compatible techniques are discussed in order to summarize its development in recent years. First, the enhancement principle and mechanism of SERS technology are briefly overviewed. The second part is devoted to a label‐free strategy for the detection of bacterial cells and bacterial metabolites. In this section, important considerations that must be made to improve bacterial SERS signals are discussed. Then, the label‐based SERS strategy involves the design strategy of SERS tags, the immunomagnetic separation of SERS tags, and the capture of bacteria from solution and dye‐labeled SERS primers. In the third part, several novel SERS compatible technologies and applications in clinical and food safety are introduced. In the final part, the results achieved are summarized and future perspectives are proposed.