bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interstitial lung disease in patients with antisynthetase syndrome: a retrospective case series study
Authors: Baratella Elisa , Marrocchio Cristina , Cifaldi Rossella , Santagiuliana Mario , Bozzato Alessandro Marco , Crivelli Paola , Ruaro Barbara , Salton Francesco , Confalonieri Marco , Cova Maria Assunta 
Published: September 2020

Abstract
Purpose
Antisynthetase syndrome (ASS) is a rare systemic autoimmune condition associated to the presence of anti-aminoacyl-tRNA synthetase antibodies. Interstitial lung disease (ILD) is the most prevalent manifestation of ASS and is a major determinant of morbidity and mortality. The aim of this study was to describe the radiological characteristics of patients with ASS-associated-ILD in our institution.

Materials and methods
Medical records from 2014 to 2020 were retrospectively reviewed and patients with a diagnosis of ASS and evidence of ILD on HRCT were included. HRCT images were reviewed by two thoracic radiologists in consensus. Five HRCT patterns were defined: cellular non-specific interstitial pneumonia (NSIP), organizing pneumonia (OP), mixed NSIP/OP pattern, acute interstitial pneumonia (AIP) pattern and fibrotic pattern. Descriptive statistics was calculated for all variables.

Results
Twenty-two patients with ASS who met inclusion criteria were included. The disease presented with the typical triad of ASS in 45% of patients, 55% had ILD only at the onset. Cellular NSIP was present in 27% of patients, OP in 23%, mixed NSIP/OP in 9%, AIP in 18% and a fibrotic pattern in 23%.

Conclusion
HRCT findings in ASS-associated ILD are often non-specific; nevertheless, it is important to consider this diagnosis, especially in patients presenting with acute onset of symptoms.
Common Factors Underlying the Five Facets of Mindfulness and Proposed Mechanisms: a Psychometric Study Among Meditators and Non-meditators
Authors: Bednar Kathrin , Voracek Martin , Tran Ulrich S. 
Published: September 2020

Abstract
Objectives
This study investigated whether common factors underlie the established mindfulness facets, as assessed by the Five Facet Mindfulness Questionnaire (FFMQ) and some of the mechanisms, which have been previously proposed to explain the beneficial effects of mindfulness on mental health.

Methods
Multigroup exploratory structural equation models (ESEM) were fitted to samples of non-meditators and meditators (total N = 3265) to (1) identify the number of factors that underlie the facets and mechanisms of mindfulness, (2) establish measurement invariance, and (3) conduct path analyses to determine the associations of extracted factors with psychological symptoms.

Results
Five measurement-invariant common factors were found to underlie the mechanisms and facets of mindfulness. The FFMQ facets loaded distinctly, but none of them highest, on these common factors. The common factors represented different ways of focusing, dealing with distress, and relating towards one’s own thoughts, feelings, emotions, and body sensations. Three of the common factors appeared to specifically reflect meditation experience. The FFMQ facets accounted for less variance of depression, anxiety, somatization, and stress scores than marker scales of the five common factors, all of which derived from the proposed mechanisms.

Conclusions
The common factors appear to be elements of the supporting mechanisms and psychological faculties of mindfulness. Their existence may explain the mutual interrelations between mechanisms and self-reported mindfulness but also suggests that self-reported mindfulness may not be factorially distinct from its assumed mechanisms. Longitudinal studies as well as behavioral data are needed to probe the generalizability and causality of these psychometric results.
Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients
Authors: Daneshkhah Ali , Agrawal Vasundhara , Eshein Adam , Subramanian Hariharan , Roy Hemant Kumar , Backman Vadim 
Published: September 2020

Abstract
Objectives
We present evidence for a possible role of Vitamin D (VitD) deficiency in unregulated cytokine production and inflammation leading to complications in COVID-19 patients.

Design
The time-adjusted case mortality ratio (T-CMR) was estimated as the ratio of deceased patients on day N to the confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was calculated as a metric of COVID-19 associated mortality. A model based on positivity change (PC) and an estimated prevalence of COVID-19 was used to determine countries with similar screening strategies. A possible association of A-CMR with the mean concentration of 25-hydroxyvitamin D (25(OH)D) in elderly individuals in countries with similar screening strategy was investigated. We considered high C-reactive protein (CRP) in severe COVID-19 patients (CRP ≥ 1 mg/dL) as a surrogate of a cytokine storm. We considered high-sensitivity CRP (hs-CRP) in healthy subjects as hs-CRP ≥ 0.2 mg/dL.

Results
A link between 25(OH)D and A-CMR in countries with similar screening strategy is evidence for VitD’s possible role in reducing unregulated cytokine production and inflammation among patients with severe COVID-19. We observed an odds ratio (OR) of 1.8 with 95% confidence interval (95% CI) (1.2 to 2.6) and an OR of 1.9 with 95% CI (1.4 to 2.7) for hs-CRP in VitD deficient elderly from low-income families and high-income families, respectively. COVID-19 patient-level data show an OR of 3.4 with 95% CI (2.15 to 5.4) for high CRP in severe COVID-19 patients.

Conclusion
We conclude that future studies on VitD’s role in reducing cytokine storm and COVID-19 mortality are warranted.
Tribological properties of MoS2 coating for ultra-long wear-life and low coefficient of friction combined with additive g-C3N4 in air
Authors: Zhang Yupeng , Li Panpan , Ji Li , Liu Xiaohong , Wan Hongqi , Chen Lei , Li Hongxuan , Jin Zhiliang 
Published: September 2020

AbstractThe solid lubricant MoS2 demonstrates excellent lubricating properties, but it spontaneously oxidizes and absorbs moisture in air, and thus results in poor wear resistance and short wear-life. In this study, the additive g-C3N4 (CN) was successfully combined with MoS2 via hydrothermal synthesis as a solid lubricant for the first time. Meanwhile, a low friction coefficient (COF, μ = 0.031) and ultra-long wear-life of CN/MoS2 compared to pure MoS2 in air were demonstrated. The functional groups and good crystallinity of the lubricant material were characterized via Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD). The formed valence states in CN/MoS2 were analyzed via X-ray photoelectron spectroscopy (XPS). The characterized results of the scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM) show the morphology and interior crystal phase structure of CN/MoS2. From the cross-section analysis, the presence of iron oxide nanoparticles lubricating film is synergistic with CN/MoS2 film during the friction process, resulting in its ultra-long wear-life. In particular, the friction mechanism of interlayer sliding friction combined with energy storage friction was analyzed and proposed.
Sarcopenia in chronic kidney disease: what have we learned so far?
Authors: Sabatino Alice , Cuppari Lilian , Stenvinkel Peter , Lindholm Bengt , Avesani Carla Maria 
Published: September 2020

AbstractThe term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed and published in consensus papers from geriatric societies. Sarcopenia was proposed to be diagnosed based on operational criteria using two components of muscle abnormalities, low muscle mass and low muscle function. This brought awareness of an important nutritional derangement with adverse outcomes for the overall health. In parallel, many studies in patients with chronic kidney disease (CKD) have shown that sarcopenia is a prevalent condition, mainly among patients with end stage kidney disease (ESKD) on hemodialysis (HD). In CKD, sarcopenia is not necessarily age-related as it occurs as a result of the accelerated protein catabolism from the disease and from the dialysis procedure per se combined with low energy and protein intakes. Observational studies showed that sarcopenia and especially low muscle strength is associated with worse clinical outcomes, including worse quality of life (QoL) and higher hospitalization and mortality rates. This review aims to discuss the differences in conceptual definition of sarcopenia in the elderly and in CKD, as well as to describe etiology of sarcopenia, prevalence, outcome, and interventions that attempted to reverse the loss of muscle mass, strength and mobility in CKD and ESKD patients.
Efficacy and Safety of Baricitinib in Chinese Rheumatoid Arthritis Patients and the Subgroup Analyses: Results from Study RA-BALANCE
Authors: Yang Yue , Li Xing-Fu , Zhang Xiao , Bao Chun-De , Hu Jian-Kang , Xu Jian-Hua , Li Xiang-Pei , Xu Jian , He Dong-Yi , Li Zhi-Jun , Wang Guo-Chun , Wu Han-Jun , Ji Fei , Zhan Lu-Jing , Zerbini Cristiano A. F. , Li Zhan-Guo 
Published: September 2020

AbstractIntroductionBaricitinib is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK 2, which has demonstrated significant efficacy in patients with moderately to severely active rheumatoid arthritis (RA). This analysis aims to describe the efficacy and safety of baricitinib in Chinese RA patients with an inadequate response to methotrexate (MTX-IR), and to analyze the effects of baseline characteristics on the efficacy of baricitinib treatment.MethodsIn this 52-week, randomized, double-blind, placebo-controlled study, 231 Chinese patients with moderately to severely active RA who had MTX-IR were randomly assigned to placebo (n = 115) or baricitinib 4 mg once daily (n = 116). The primary endpoint was American College of Rheumatology 20% (ACR20) response at week 12. Other efficacy measures included ACR50, ACR70, Physician’s Global Assessment of Disease Activity, Patient’s Global Assessment of Disease Activity, patient’s assessment of pain, Disease Activity Score in 28 joints using high-sensitivity C-reactive protein, remission and low disease activity rates according to Simplified Disease Activity Index or Clinical Disease Activity Index, Health Assessment Questionnaire-Disability Index, and mean duration and severity of morning joint stiffness, worst tiredness and worst joint pain were analyzed. Additionally, subgroup analyses were performed across baseline characteristics.ResultsStatistically significant improvement in ACR20 response was achieved with baricitinib at week 12 (53.4 vs. 22.6%,p = 0.001) in Chinese patients, compared to placebo. Most of the secondary objectives were met with statistically significant improvements. Efficacy of baricitinib was irrespective of patient demographics and baseline characteristics. Safety events were similar between the baricitinib and placebo groups.ConclusionsThe efficacy of baricitinib 4 mg in Chinese patients with moderately to severely active RA and prior MTX-IR was clinically significant compared to placebo regardless of baseline characteristics. Baricitinib was well tolerated with an acceptable safety profile during the full study period.Trial RegistrationNCT02265705
Two-Dimensional Black Phosphorus Nanomaterials: Emerging Advances in Electrochemical Energy Storage Science
Authors: Cheng Junye , Gao Lingfeng , Li Tian , Mei Shan , Wang Cong , Wen Bo , Huang Weichun , Li Chao , Zheng Guangping , Wang Hao , Zhang Han 
Published: September 2020

AbstractTwo-dimensional black phosphorus (2D BP), well known as phosphorene, has triggered tremendous attention since the first discovery in 2014. The unique puckered monolayer structure endows 2D BP intriguing properties, which facilitate its potential applications in various fields, such as catalyst, energy storage, sensor, etc. Owing to the large surface area, good electric conductivity, and high theoretical specific capacity, 2D BP has been widely studied as electrode materials and significantly enhanced the performance of energy storage devices. With the rapid development of energy storage devices based on 2D BP, a timely review on this topic is in demand to further extend the application of 2D BP in energy storage. In this review, recent advances in experimental and theoretical development of 2D BP are presented along with its structures, properties, and synthetic methods. Particularly, their emerging applications in electrochemical energy storage, including Li−/K−/Mg−/Na-ion, Li–S batteries, and supercapacitors, are systematically summarized with milestones as well as the challenges. Benefited from the fast-growing dynamic investigation of 2D BP, some possible improvements and constructive perspectives are provided to guide the design of 2D BP-based energy storage devices with high performance.
Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
Authors: Zhang Songtao , Jin Longhai , Liu Jianhua , Liu Yang , Zhang Tianqi , Zhao Ying , Yin Na , Niu Rui , Li Xiaoqing , Xue Dongzhi , Song Shuyan , Wang Yinghui , Zhang Hongjie 
Published: September 2020

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.
Formation of Chinese venture capital syndication network
Authors: Nirei Makoto , Shoji Toshiaki , Yu Fei 
Published: September 2020

AbstractUsing a dataset that recorded a large number of investment transactions in China from 1991 to 2018, we examine the statistical properties of the Chinese venture capital (VC) syndication network. Our main findings are as follows. First, the number of investment transactions sharply increased after 2014. Second, more than half of the VC firms are located in Beijing, Shanghai, and Shenzhen. Third, the degree distribution becomes roughly straight on a log–log plot. Fourth, the hypothesis that the degree distribution follows a power-law distribution is not rejected for 2015 and 2016. Fifth, better connected VC firms increase their connectivity faster, which suggests the existence of preferential attachment.
Why Do Corporations Engage in LGBT Rights Activism? LGBT Employee Groups as Internal Pressure Groups
Authors: Maks-Solomon Cory , Drewry Josiah Mark 
Published: September 2020

AbstractMost scholarship on corporate political activity assumes that market forces wholly motivate firms’ political strategies. However, this conventional wisdom overlooks the role of employee groups in encouraging corporate activism. To evaluate whether employee groups are associated with firm social activism, we gathered all public statements in support of LGBT rights made by the five hundred largest publicly-traded US corporations from 2011 to 2017. In an exploratory observational analysis, we found robust evidence that in highly-educated workforces LGBT employee groups persuade management to take public stances in support of LGBT rights. Our findings suggest that internal pressure promotes activism on LGBT issues, and market, political, or social forces are insufficient to fully explain firm social activism. Although each does play an important role, since employee groups will use political, social, and especially market-based arguments to convince their managers to engage in activism.
Evidence Review and Practice Recommendation on the Material, Design, and Maintenance of Cloth Masks
Authors: Sunjaya Anthony Paulo , Morawska Lidia 
Published: September 2020

ABSTRACTDespite numerous masking recommendations from public health agencies, including the World Health Organization, editorials, and commentaries providing support for this notion, none had examined different homemade masks or demonstrated that perhaps not all cloth masks are the same. This article aims to provide evidence-based recommendations on cloth-mask materials, its design, and, importantly, its maintenance. Articles were obtained from PubMed and preprint servers up to June 10, 2020. Current evidence suggests that filtration effectiveness can range from 3% to 95%. Multiple layer (hybrid) homemade masks made from a combination of high density 100% cotton and materials with electrostatic charge would be more effective than one made from a single material. Mask fit greatly affects filtration efficiency, and adding an overhead knot or nylon overlay potentially provides the best fit for cloth masks. There is a paucity of evidence for masks maintenance as most studies are in the laboratory setting; however, switching every 4 hours as in medical masks and stored in dedicated containers while awaiting disinfection is recommended. Outside of these recommendations to improve the effectiveness of cloth masks to reduce infection transmission, there is a need for countries to set up independent testing labs for homemade masks made based on locally available materials. This can use existing occupational health laboratories usually used for accrediting masks and respirators.
The ontological politics of cyber security: Emerging agencies, actors, sites, and spaces
Authors: Liebetrau Tobias , Christensen Kristoffer Kjærgaard 
Published: September 2020

AbstractIn this article, we show how Annemarie Mol's notion of ontological politics helps to open up the research agenda for cyber security in Critical Security Studies. The article hence seeks to further the debate about STS and Critical Security Studies. The article's main claim is that the concept of ontological politics enables an engagement with the complex and transformative dynamics of ICT and the new security actors and practices that shape security politics in the digital age. By examining the virulent attacks executed by the Mirai botnet – one of the world's largest, fiercest, and most enduring botnets – we point to four aspects of cyber security that attention to the ontological politics of cyber security attunes us to: the proliferation and entanglement of security agencies, actors, sites, and spaces. These aspects of cyber security, we argue, are becoming increasingly prominent alongside the development of the Internet of Things (IoT) and 5G network technology. In conclusion, we discuss the wider security theoretical and normative-democratic implications of an engagement with the ontological politics of security by exploring three avenues for additional conversation between ontological politics and Critical Security Studies.
Do Functions Explain? Hegel and the Organizational View
Authors: Cooper Andrew 
Published: September 2020

AbstractIn this paper I return to Hegel's dispute with Kant over the conceptual ordering of external and internal purposiveness to distinguish between two conceptions of teleology at play in the contemporary function debate. I begin by outlining the three main views in the debate (the etiological, causal role and organizational views). I argue that only the organizational view can maintain the capacity of function ascriptions both to explain the presence of a trait and to identify its contribution to a current system, for it is the only view that considers teleology as a natural cause. To establish how teleology can be considered as a natural cause, advocates of the organizational view return to Kant's analysis of internal purposiveness. However, while Kant identifies the requirements that an object must meet to satisfy the demands of teleological judgment, I suggest that he denies that we can know whether they are truly met. I argue that Hegel's philosophy of nature is better equipped to determine how internal purposiveness can be considered as a natural cause, for it grounds organization in a form of purposiveness that is more fundamental than a designer's intention.
Associations of early-life exposure to famine with abdominal fat accumulation are independent of family history of diabetes and physical activity
Authors: Hu Xiang , Wen Junping , Yu Weihui , Yang Lijuan , Pan Wei , Xu Ke , Chen Xueqin , Li Qianqian , Chen Gang , Gu Xuejiang 
Published: September 2020

AbstractThe present study aimed to investigate the association of early-life exposure to famine with abdominal fat accumulation and function and further evaluate the influence of first-degree family history of diabetes and physical activity on this association. The present work analysed parts of the REACTION study. A total of 3033 women were enrolled. Central obesity was defined as waist circumferences (W) ≥ 85 cm. Chinese visceral adiposity index (CVAI) was used to evaluate visceral adipose distribution and function. Partial correlation analysis showed BMI, W, glycated Hb and CVAI were associated with early-life exposure to famine (both P < 0·05). Logistic regression showed that the risks of overall overweight/obesity and central obesity in fetal, early-childhood, mid-childhood and late-childhood exposed subgroups were increased significantly (all P < 0·05). Compared with the non-exposed group, the BMI, W and CVAI of fetal, early- to late-childhood exposed subgroups were significantly increased both in those with or without first-degree family history of diabetes and in those classified as physically active or inactive, respectively (all P < 0·05). The associations of BMI, W and CVAI with early-life exposure to famine were independent of their associations with first-degree family history of diabetes (all P < 0·01) or physical activity status (all P < 0·001). Early-life exposure to famine contributed to abdominal fat accumulation and dysfunction, which was independent of the influence of genetic background and exercise habits. Physical activity could serve as a supplementary intervention for women with high risk of central obesity.