bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower limb coordination during gait in people with moderate Parkinson's disease
Authors: Filippin Nadiesca T , Martins Karina C , Narimoto Lidiane R , Da Costa Paula HL , Mattioli Rosana 
Published: April 2020

Background/Aims Parkinson's disease interferes with the control of movement, which can cause changes in coordination. The aim of this study was to compare intralimb and interlimb coordination during gait in people with Parkinson's disease and in typically healthy people. Methods Participants were split into two groups. A total of 10 participants with Parkinson's disease were in the study group and 10 typically healthy participants were in the control group. All participants underwent a clinical evaluation, a gait kinematic evaluation for spatiotemporal variables and joint angle range of motion and an intralimb and interlimb coordination analysis. Results The duration of the stride, stance and swing phases of the gait cycle were longer in individuals with Parkinson's disease, who also displayed shorter stride length, slower speed and reduced cadence and joint range of motion than participants in the control group. Intralimb and interlimb coordination did not differ significantly between the groups. Conclusions Participants with Parkinson's disease presented with alterations in spatiotemporal variables and joint range of motion but were able to adapt to the limitations imposed by the disease and accomplish a functional gait without undermining their intralimb and interlimb coordination pattern.
Effect of augmented biofeedback for improvement of range of motion and upper extremity functionality in obstetric brachial plexus injury: a randomised control trial
Authors: Alsakhawi Reham Saeed , Atya Azza Mohamed 
Published: April 2020

Background/Aims The loss of mobility and functional activities of the upper limb are the main longstanding complications of obstetric brachial plexus injury. The aim of this study was to investigate the effect of the augmented biofeedback system in conjunction with traditional physical therapy on the range of motion and functional activities in children with obstetric brachial plexus injury. Methods A total of 45 children aged from 6 to 10 years with obstetric brachial plexus injury were assigned into two groups. The control group received a traditional physical therapy programme, and the study group received the same programme with augmented biofeedback for 6 weeks. The main outcome parameters were the upper limb active range of motion, Mallet scale and Active Movement scale. Results The children in the study group showed greater significant improvement in all measured parameters compared with those in the control group. Conclusions Adding augmented biofeedback to the physical therapy programme provided greater improvement in upper limb mobility and functional activities for children with obstetric brachial plexus injury children.
Design considerations for advanced MWIR target acquisition systems
Authors: Holst Gerald C. , Driggers Ronald , Furxhi Orges 
Published: April 2020

In this paper, mid-wave infrared (MWIR) sensor optimization is provided as a function of the parameter Fλ/d, where F is the f-number, λ is the effective wavelength, and d is the detector pitch. For diffraction limited systems, acquisition range is related to the instantaneous field of view (detector limited operation) when Fλ/d<1, and to the optical properties (optics limited operation) when Fλ/d>2.0. Range performance is a combination of detector and optics resolution limits when Fλ/d is in between. When the system is not strictly diffraction or sampling limited, the optimal Fλ/d depends on other system component characteristics and conditions. Optical system aberrations affect system resolution and decrease range performance. As background shot noise, dark current shot noise, and read noise increase, range decreases. In the infrared spectral region, atmospheric absorption leads to reemission of thermal energy. The detected reemission creates additional shot noise. Atmospheric attenuation greatly affects MWIR sensor range performance. Next-generation MWIR sensors will have smaller detectors, larger arrays, and better sensitivity to enable Fλ/d-based optimization. Previous studies (ΔT=4K for tracked vehicles) suggest that an initial design point is Fλ/d≈2.0. When detecting low contrast targets (ΔT∼0.1K), sensor gain is used to increase the signal for a desired displayed contrast. This gain increases displayed noise and reduces acquisition range. This is typically not an issue for long-wave infrared sensors due to the excess number of photons in the 8–12 µm band but poses a problem for MWIR sensors, which are photon starved. Under such scenarios, the optimum Fλ/d appears to be about 1.5 for MWIR sensors. The results here provide reasonable strategies for MWIR system optimization and a direction associated with future MWIR focal plane development.
Impact of Inadequate Bowel Cleansing on Colonoscopic Findings in Routine Screening Practice
Authors: Niedermaier Tobias , Amitay Efrat L. , Gies Anton , Weigl Korbinian , Hoffmeister Michael , Brenner Hermann 
Published: April 2020

INTRODUCTION:
Colonoscopy is an imperfect gold standard for detecting colorectal neoplasms because some proportion of adenomas may be missed, mainly small lesions. This proportion is expected to be higher in case of inadequate bowel cleansing, which is frequently seen in routine practice. We estimated the proportions of neoplasms that are in principle detectable by colonoscopy but might be missed in case of incomplete bowel preparation.

METHODS:
For 8,193 participants of screening colonoscopy in South-Western Germany, recruited between 2005 and 2016, the prevalence and numbers of different findings were extracted from colonoscopy reports and compared according to the reported bowel preparation quality.

RESULTS:
Bowel preparation quality was reported as good, poor, or was unspecified in 30.3%, 11.1%, and 58.6% of colonoscopy records. Reported prevalences of nonadvanced adenomas (NAAs) were similar among participants with poor and unspecified bowel preparation quality but substantially lower than among participants with good bowel preparation (adjusted prevalence rate ratio [RR] 0.86, 95% confidence interval [CI]: 0.77–0.96). The differences were observed for proximal but not for distal NAAs (RRs 0.82, 95% CI: 0.71–0.95 and 0.95, 95% CI: 0.82–1.10).

DISCUSSION:
Our study suggests that a significant proportion of NAAs located in the proximal colon might be missed during colonoscopy if bowel cleansing is not adequate. Major efforts should be made to further facilitate and enhance high-quality bowel preparation in routine screening practice.
A Comparison of Kinetic and Kinematic Variables During the Pull From the Knee and Hang Pull, Across Loads
Authors: Meechan David , McMahon John J. , Suchomel Timothy J. , Comfort Paul 
Published: April 2020

Abstract
Meechan, D, McMahon, JJ, Suchomel, TJ, and Comfort, P. A comparison of kinetic and kinematic variables during the pull from the knee and hang pull, across loads. J Strength Cond Res 34(7): 1819–1829, 2020—Kinetic and kinematic variables during the pull from the knee (PFK) and hang pull (HP) were compared in this study. Eighteen men (age = 29.43 ± 3.95 years; height 1.77 ± 0.08 m; body mass 84.65 ± 18.79 kg) performed the PFK and HP with 40, 60, 80, 100, 120, and 140% of 1-repetition maximum (1RM) power clean, in a progressive manner. Peak force (PF), mean force (MF), peak system velocity (PSV), mean system velocity (MSV), peak power (PP), mean power (MP), and net impulse were calculated from force-time data during the propulsion phase. During the HP, small-to-moderate yet significantly greater MF was observed compared with the PFK, across all loads (p ≤ 0.001; Hedges g = 0.47–0.73). Hang pull PSV was moderately and significantly greater at 100–140% 1RM (p = 0.001; g = 0.64–0.94), whereas MSV was significantly greater and of a large-to-very large magnitude compared with PFK, across all loads (p < 0.001; g = 1.36–2.18). Hang pull exhibited small to moderate and significantly greater (p ≤ 0.011, g = 0.44–0.78) PP at 100–140%, with moderately and significantly greater (p ≤ 0.001, g = 0.64–0.98) MP across all loads, compared with the PFK. Hang pull resulted in a small to moderate and significantly greater net impulse between 100 and 140% 1RM (p = 0.001, g = 0.36–0.66), compared with PFK. The results of this study demonstrate that compared with the PFK, the HP may be a more beneficial exercise to enhance force-time characteristics, especially at loads of ≥1RM.
Velocity Performance Feedback During the Free-Weight Bench Press Testing Procedure: An Effective Strategy to Increase the Reliability and One Repetition Maximum Accuracy Prediction
Authors: Jiménez-Alonso Ainara , García-Ramos Amador , Cepero Mar , Miras-Moreno Sergio , Rojas Francisco Javier , Pérez-Castilla Alejandro 
Published: April 2020

Abstract
Jiménez-Alonso, A, García-Ramos, A, Cepero, M, Miras-Moreno, S, Rojas, FJ, and Pérez-Castilla, A. Velocity performance feedback during the free-weight bench press testing procedure: An effective strategy to increase the reliability and one repetition maximum accuracy prediction. J Strength Cond Res 36(4): 1077–1083, 2022—This study aimed to determine whether the verbal provision of velocity performance feedback during the free-weight bench press (BP) exercise influences (a) the within-session reliability and magnitude of mean concentric velocity (MCV) values recorded against a range of submaximal loads and (b) the accuracy of the individualized load-velocity profile to estimate the BP 1 repetition maximum (1RM). Fifteen men (BP 1RM relative to body mass = 1.08 ± 0.22) performed an incremental loading test until reaching the 1RM on 2 separate sessions. Subjects received verbal velocity performance feedback in 1 session (knowledge of results [KR]), and no KR was provided in another session (Control). A linear velocity transducer was used to collect the MCV against 4 loads (40-55-70-85% 1RM), and the BP 1RM was estimated from the individualized load-velocity relationship modeled through the multiple-point (40-55-70-85% 1RM) and 2-point methods (40-85% 1RM). The KR condition provided a higher reliability (coefficient of variation [CV]: KR = 2.41%, Control = 3.54%; CV ratio = 1.47) and magnitude (p = 0.001; effect size [ES] = 0.78) of MCV for the 40% 1RM, but no significant differences in reliability (CV ratio ≤1.15) nor in the magnitude (p ≥ 0.058; ES range = 0.00–0.32) were observed for higher loads. The accuracy in the estimation of the 1RM was higher for the KR (absolute errors: multiple-point = 3.1 ± 2.3 kg; 2-point = 3.5 ± 2.1 kg) compared with the Control condition (absolute errors: 4.1 ± 1.9 kg for both multiple-point and 2-point methods). These results encourage the provision of verbal velocity performance feedback during BP testing procedures.
Real-World Outcomes Among Older Mexican Women with Breast Cancer Treated with Neoadjuvant Chemotherapy
Authors: Cabrera-Galeana Paula , Soto-Perez-de-Celis Enrique , Reynoso-Noveron Nancy , Villarreal-Garza Cynthia , Lara-Medina Fernando , Alvarado-Miranda Alberto , Espinosa-Fernandez José Rodrigo , Esparza-Arias Nereida , Mohar Alejandro , Bargallo-Rocha Juan Enrique 
Published: April 2020

Abstract

Background
Older patients with breast cancer treated in high-income countries often present with early-stage disease, leading to a lack of information on the use of neoadjuvant chemotherapy in this population. We analyzed the real-world outcomes of older women with breast cancer treated with neoadjuvant chemotherapy at a single institution in Mexico.

Materials and Methods
The study included 2,216 patients treated with neoadjuvant chemotherapy. Regarding achievement of pathologic complete response (defined as no invasive residual tumor in the breast and lymph nodes), 243 patients aged ≥65 years were compared with 1,973 patients aged &lt;65 years. Disease-free survival and overall survival were compared between groups according to pathologic complete response and subtype, defined by hormone receptor and human epidermal growth receptor 2 (HER2) status.

Results
Older women were less likely to have a pathologic complete response than their younger counterparts (26.3 vs. 35.3%, p &lt; .001). When response rates by subtype were analyzed, this difference was significant only for women with triple-negative tumors. Achieving less than a pathologic complete response was associated with a greater chance of recurrence, but age was not an independent factor for recurrence for any subtype. Reaching a pathologic complete response was significantly associated with improved survival among older women with breast cancer, with the exception of those with hormone receptor–positive, HER2− disease.

Conclusion
Although older women have fewer pathological complete responses, their outcomes after neoadjuvant chemotherapy are comparable to those of younger patients. This is particularly relevant for the treatment of older adults with breast cancer in developing countries, who present in advanced stages and more often need neoadjuvant therapy.

Implications for Practice
The majority of older patients with breast cancer in high-income countries present with early-stage disease, leading to a lack of information regarding the use of neoadjuvant chemotherapy in real-world settings. This article reports the outcomes of older Mexican women with breast cancer who received neoadjuvant chemotherapy compared with their younger counterparts. Although older women (particularly those with triple-negative tumors) were less likely to have a pathologic complete response after neoadjuvant treatment, age was not an independent factor for recurrence. Achieving a pathologic complete response was associated with improved survival, regardless of age.
Impact of Treatment Beyond Progression with Immune Checkpoint Blockade in Hodgkin Lymphoma
Authors: Merryman Reid W. , Carreau Nicole A. , Advani Ranjana H. , Spinner Michael A. , Herrera Alex F. , Chen Robert , Tomassetti Sarah , Ramchandren Radhakrishnan , Hamid Muhammad , Assouline Sarit , Santiago Raoul , Wagner-Johnston Nina , Paul Suman , Svoboda Jakub , Bair Steven M. , Barta Stefan K. , Liu Yang , Nathan Sunita , Karmali Reem , Burkart Madelyn , Torka Pallawi , David Kevin A. , Wei Catherine , Lansigan Frederick , Emery Lukas , Persky Daniel , Smith Sonali M. , Godfrey James , Chavez Julio , Cohen Jonathan B. , Troxel Andrea B. , Diefenbach Catherine , Armand Philippe 
Published: April 2020

Abstract
Atypical response patterns following immune checkpoint blockade (ICB) in Hodgkin lymphoma (HL) led to the concept of continuation of treatment beyond progression (TBP); however, the longitudinal benefit of this approach is unclear. We therefore performed a retrospective analysis of 64 patients treated with ICB; 20 who received TBP (TBP cohort) and 44 who stopped ICB at initial progression (non-TBP cohort). The TBP cohort received ICB for a median of 4.7 months after initial progression and delayed subsequent treatment by a median of 6.6 months. Despite receiving more prior lines of therapy, the TBP cohort achieved longer progression-free survival with post-ICB treatment (median, 17.5 months vs. 6.1 months, p = .035) and longer time-to-subsequent treatment failure, defined as time from initial ICB progression to failure of subsequent treatment (median, 34.6 months vs. 9.9 months, p = .003). With the limitations of a retrospective study, these results support the clinical benefit of TBP with ICB for selected patients.
Modern Concepts in Russian Constitutional Law
Authors: Dudko I. G. 
Published: April 2020

The change of the scientific paradigm in Russian jurisprudence is accompanied by the affirmation of pluralism in a legal science. The paper has highlighted that the modern Russian constitutional theory seeks to express itself in the problems of ontological and axiological foundations, claiming to form an integral ”constitutional philosophy.”Constitutional axiology represents one of the most significant concepts of constitutionalism. Constitutional axiology is built as a field of scientific reflection (the nature, content, system of constitutional values). From these standpoints, the author provides for the assessment of law-enforcement carried out by the body of constitutional justice. The paper recognizes the high importance of research of constitutional law from the axiological point of view.The author has concluded that constitutional values as a reflection and expression of the “charter” of the life of the society (“protoconstitutional”) represent objectivated systemic totality functioning as the ultimate goal of constitutional development. Constitutional values represent concepts that must correspond to the social and spiritual environment of the society and the purpose of the State.The paper critically assesses the concept of a “living constitution” in its Russian interpretation as the constitutional and appraisal activity of the Constitutional Court of the Russian Federation with regard to “generation” of constitutional values. It is noted that the result of the work of the Constitutional Court of the Russian Federation expressed in its legal determinations, can not represent other (“generated” by it) constitutional values except those contained in the Constitution of the Russian Federation. “Transformation” of the content and legal attitudes and meanings of the Constitution, constitutional values without changing the text of the Constitution may lead to “distortions” of the essence of the Constitution and intent for the Constitution to be an act with the highest legal force.
Significance of Prof. Ekaterina I. Kozlova’s Academic Legacy for the Modern Understanding of the Legislative Process and Legislation
Authors: Narutto S. V. 
Published: April 2020

The paper deals with the issues of law-making development in the context of actual ideas of Prof. Ekaterina I. Kozlova with regard to the place of a legislative body in the system of state power, order and the results of its activities, the problems of limits of legislative regulation and the politicization of legislation leading to a decline in the quality of laws. The author substantiates the conclusion that the expansion of legislative regulation creates problems, including conflict-of-laws rules, legal uncertainty, numerous references to regulation carried out through bylaws. Excessive legislative regulation leads to restriction of human rights and freedoms, hinders democratic processes. At the same time, the existence of gaps in the legislative material leads to arbitrary interpretation and unlimited discretion of the enforcement.Prof. Kozlova’s works have been developed in the modern scientific doctrine of parliamentarism, federal legislative process and legislation, public control.
Study of paediatric systemic lupus erythematosus in tertiary care center in South India
Authors: S. Shashidhara V. , H. Anil Kumar , Kariyappa Mallesh 
Published: April 2020

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies directed against self-antigens. The reported prevalence of SLE in children and adolescents (1-6/100,000) is lower than that in adults (20-70/100,000). The study among pediatric population were few and hence this study from south India was undertaken. Objective of this study was to study the clinical and immunological profile of children with systemic lupus erythematosus (SLE). To study the Distribution of Renal Lesions according to ISN/RPS Classification of Lupus Nephritis Methods: Retrospective hospital based observational study in tertiary level centre in Bengaluru (BMCRI). Medical records of children with SLE admitted in Pediatric department from the period of 2010-2019 through the hospital information system were analyzed. Clinico pathological features and immunological profile were compared with other studies.Results: Among 25 patients studied male to female ratio was1:2.5. The mean patient’s age at the time of presentation was13.2 year, the youngest child being 7 year. The mean duration of disease before diagnosis was 1year, most common systems involved were haematological (92%), followed by kidney (88%), GIT (72%), mucocutaneous (68%) cases. 19 (91%) cases were ANA positive and two ANA negatives. Anti-ds DNA was positive in 18(85%) patients, 5 were anti smith antibody positive. Diffuse proliferative glomerulonephritis (ISN/RPS class IV) was the most commonly seen histological pattern, seen in 9(56%) patients, 4(25%) patient had focal and segmental proliferative glomerulonephritis (ISN/RPS class III) and 2(12%) had membranous glomerulonephritis (grade ISN/RPS class V).Conclusions: SLE can present with diverse, unpredictable clinical manifestations, the primary diagnosis can often be missed if the index of suspicion is not high, since childhood SLE does not present with classical manifestations.
Diagnosis of small airway dysfunction in patients with chronic obstructive pulmonary disease
Authors: Cherniak A. V. , Savushkina O. I. , Pashkova T. L. , Kryukov E. V. 
Published: April 2020

Background: Small airway dysfunction (SAD) is a functional hallmark of chronic obstructive pulmonary disease (COPD). However, SAD prevalence and its role in COPD pathophysiology are not yet sufficiently studied.Background: Small airway dysfunction (SAD) is a functional hallmark of chronic obstructive pulmonary disease (COPD). However, SAD prevalence and its role in COPD pathophysiology are not yet sufficiently studied.Aim: To assess the prevalence of SAD in COPD patients by various functional diagnostic methods, such as spirometry, body plethysmography, and impulse oscillometry (IOS).Materials and methods: This was an cross-sectional study. Spirometry, body plethysmography and IOS were used in 132 COPD patients in remission under standard anti-COPD treatments. The presence of SAD was confirmed by at least one of the following criteria or their combination: 1) by spirometry: the difference between vital capacity (VC) and forced vital capacity (FVC) > 10%; 2) the presence of air trapping by body plethysmography; 3) identification of the frequency dependence of the resistive resistance at 5 to 20 Hz (R5 - R20 > 0.07 kPa x s/l), as assessed by IOS.Results: Mean forced expiratory volume in 1 s (FEV1) was 42.9% of predicted. Depending on the severity of the obstruction, the patients were divided into 4 groups: 7 patients (group 1) had the obstruction corresponding to GOLD 1 stage, 37 (group 2) to GOLD 2, 49 (group 3) to GOLD 3, and 39 (group 4) to GOLD 4. SAD was found in 96% of COPD patients, whereas in those with severe obstruction (GOLD 3-4), it was present in 100% of the cases. By spirometry, SAD was identified only in 67% of COPD patients, by body plethysmography in 75% of COPD patients (in those with severe obstruction (GOLD 3 and 4) in 88 and 97%, respectively). With IOS, it was possible to identify SAD in 94% of patients and in 100% of those with severe obstruction (GOLD 3-4).Conclusion: With deterioration of obstructive pulmonary ventilation abnormalities in COPD patients, there is a progressive increase in small airway dysfunction. Impulse oscillometry seems to be the most effective method for diagnosis of small airway dysfunction, as it helped to identify SAD in 94% of COPD patients and in 100% of those with severe and very severe obstruction.