bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide
Authors: Ambadiang Marilene M. M. , Atontsa Brice C. K. , Tankeo Simplice B. , Nayim Paul , Wamba Brice E. N. , Bitchagno Gabin T. M. , Mpetga James D. S. , Penlap Veronique B. , Kuete Victor 
Published: November 2020

AbstractBackgroundMultidrug-resistant (MDR) bacteria remain a major cause of morbidity and mortality globally. The present study was designed to investigate the in vitro antibacterial activities of crude methanol extract and constituents isolated by Column Chromatography (CC) fromCassia sieberianabark (CSB) against ten MDR Gram-negative bacteria, as well as the mechanisms of action of the most active sample.MethodsThe antibacterial activity of the tested samples (extract, the fractions and their compounds isolated by CC and the structures obtained by exploiting1H and13CNuclear magnetic resonance(NMR) spectra) in the presence and absence of an efflux pumps inhibitor, phenylalanine-arginine β-naphthylamide (PAβN), was evaluated using the micro-dilution method. The effects of the most active sample were evaluated on the cell growth kinetic and on the bacterial H+-ATPase proton pumps.ResultsPhytochemical composition of the crude extract showed a rather selective distribution of secondary metabolites (presence of polyphenols, tannins, steroids, triterpenes, flavonoids, alkaloids, saponins and absence of anthocyanins, anthraquinones). The tested samples displayed different antibacterial activities with minimal inhibitory concentrations (MICs) ranging from 64 to 512 μg/mL. Crude extract (CS) and fraction CSc showed the highest inhibitory spectra, both inhibiting all of the studied bacteria exceptEnterobacter aerogenesEA27 strain. Fraction CSc exerted bactericidal effects on most bacteria meanwhile, crude extract (CS) and sub-fraction CSc2 exerted bacteriostatic effects. Compounds 1 (spectaline) and 2 (iso-6-cassine) inhibited the growth of 70% (Escherichia coliATCC8739 and AG102,Klebsiella pneumoniaeATCC11296,Enterobacter aerogenesATCC13048 and EA27,Providencia stuartiiATCC29916,Pseudomonas aeruginosaPA01) and 60% (Escherichia coliATCC8739,Klebsiella pneumoniaeATCC11296 and KP55,Providencia stuartiiATCC29916,Pseudomonas aeruginosaPA01 and PA124) of bacteria respectively with MICs ranging from 128 to 512 μg/mL. In the presence of PAβN, the activities of crude extract CS, fraction CAc and sub-fraction CSc2 strongly increased on most bacteria strains as their MICs significantly decreased. Sub-fraction CSc2 inhibited the H+-ATPase proton pumps and altered growth kinetic ofEscherichia coliATCC8739.ConclusionThe overall results justify the traditional use ofC. sieberianafor the treatment of bacterial infections.
Developing and maintaining the resilience of interdisciplinary cancer care teams: an interventional study
Authors: Dubois Carl-Ardy , Borgès Da Silva Roxane , Lavoie-Tremblay Mélanie , Lespérance Bernard , Bentein Kathleen , Marchand Alain , Soldera Sara , Maheu Christine , Grenier Sébastien , Fortin Marie-Andrée 
Published: November 2020

AbstractBackgroundProviding care to cancer patients is associated with a substantial psychological and emotional load on oncology workers. The purpose of this project is to co-construct, implement and assess multidimensional intervention continuums that contribute to developing the resilience of interdisciplinary cancer care teams and thereby reduce the burden associated with mental health problems. The project is based on resources theories and theories of empowerment.MethodsThe study will involve cancer care teams at four institutions and will use a mixed-model design. It will be organized into three components:(1) Intervention development.Rather than impose a single way of doing things, the project will take a participatory approach involving a variety of mechanisms (workshops, discussion forums, surveys, observations) to develop interventions that take into account the specific contexts of each of the four participating institutions.(2) Intervention implementation and assessment.The purpose of this component is to implement the four interventions developed in the preceding component, assess their effects and whether they are cost effective. A longitudinal quasi-experimental design will be used. Intervention monitoring will extend over 12 months. The effects will be assessed by means of generalized estimating equation regressions. A cost-benefit analysis will be performed to assess the cost-effectiveness of the interventions, taking an institutional perspective (costs and benefits associated with the intervention).(3) Analysis of co-construction and implementation process.The purpose of this component is to (1) describe and assess the approaches used to engage stakeholders in the co-construction and implementation process; (2) identify the factors that have fostered or impeded the co-construction, implementation and long-term sustainability of the interventions. The proposed design is a longitudinal multiple case study.DiscussionIn the four participating institutions, the project will provide an opportunity to develop new abilities that will strengthen team resilience and create more suitable work environments. Beyond these institutions, the project will generate a variety of resources (e.g.: work situation analysis tools; method of operationalizing the intervention co-development process; communications tools; assessment tools) that other oncology teams will be able to adapt and deploy elsewhere.
Sex differences in neuro(auto)immunity and chronic sciatic nerve pain
Authors: Linher-Melville Katja , Shah Anita , Singh Gurmit 
Published: November 2020

AbstractChronic pain occurs with greater frequency in women, with a parallel sexually dimorphic trend reported in sufferers of many autoimmune diseases. There is a need to continue examining neuro-immune-endocrine crosstalk in the context of sexual dimorphisms in chronic pain. Several phenomena in particular need to be further explored. In patients, autoantibodies to neural antigens have been associated with sensory pathway hyper-excitability, and the role of self-antigens released by damaged nerves remains to be defined. In addition, specific immune cells release pro-nociceptive cytokines that directly influence neural firing, while T lymphocytes activated by specific antigens secrete factors that either support nerve repair or exacerbate the damage. Modulating specific immune cell populations could therefore be a means to promote nerve recovery, with sex-specific outcomes. Understanding biological sex differences that maintain, or fail to maintain, neuroimmune homeostasis may inform the selection of sex-specific treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity using sciatica as an example.
A comprehensive research agenda for zero leprosy
Authors: Steinmann Peter , Dusenbury Courtenay , Addiss David , Mirza Fareed , Smith W. Cairns S. 
Published: November 2020

Abstract
Background
Leprosy control achieved dramatic success in the 1980s–1990s with the implementation of short course multidrug therapy, which reduced the global prevalence of leprosy to less than 1 in 10 000 population. However, a period of relative stagnation in leprosy control followed this achievement, and only limited further declines in the global number of new cases reported have been achieved over the past decade.

Main text
In 2016, major stakeholders called for the development of an innovative and comprehensive leprosy strategy aimed at reducing the incidence of leprosy, lowering the burden of disability and discrimination, and interrupting transmission. This led to the establishment of the Global Partnership for Zero Leprosy (GPZL) in 2018, with partners aligned around a shared Action Framework committed to achieving the WHO targets by 2030 through national leprosy program capacity-building, resource mobilisation and an enabling research agenda. GPZL convened over 140 experts from more than 20 countries to develop a research agenda to achieve zero leprosy. The result is a detailed research agenda focusing on diagnostics, mapping, digital technology and innovation, disability, epidemiological modelling and investment case, implementation research, stigma, post exposure prophylaxis and transmission, and vaccines. This research agenda is aligned with the research priorities identified by other stakeholders.

Conclusions
Developing and achieving consensus on the research agenda for zero leprosy is a significant step forward for the leprosy community. In a next step, research programmes must be developed, with individual components of the research agenda requiring distinct expertise, varying in resource needs, and operating over different timescales. Moving toward zero leprosy now requires partner alignment and new investments at all stages of the research process, from discovery to implementation.
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis
Authors: Reece Albert Stuart , Hulse Gary Kenneth 
Published: November 2020

Abstract
Background
Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) where cannabis use is high.

Methods
Design: Cohort. 2008–2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, alcohol, cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal regression.

Results
Cardiovascular, respiratory and gastrointestinal anomalies rose with falling tobacco and alcohol but rising cannabis use rates across Queensland. Maternal age NNSW-QLD was not different (2008–2015: 4265/22084 v. 96,473/490514 > 35 years/total, Chi.Sq. = 1.687, P = 0.194). A higher rate of NNSW cannabis-related than cannabis-unrelated defects occurred (prevalence ratio (PR) = 2.13, 95%C.I. 1.80–2.52, P = 3.24 × 10− 19). CA’s rose more potently with rising cannabis than with rising tobacco or alcohol use. Exomphalos and gastroschisis had the highest NNSW:QLD PR (6.29(2.94–13.48) and 5.85(3.54–9.67)) and attributable fraction in the exposed (84.11%(65.95–92.58%) and 82.91%(71.75–89.66%), P = 2.83 × 10− 8 and P = 5.62 × 10− 15). In multivariable geospatial models cannabis was significantly linked with cardiovascular (atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus), genetic (chromosomal defects, Downs syndrome), gastrointestinal (small intestinal atresia), body wall (gastroschisis, diaphragmatic hernia) and other (hypospadias) (AVTPCDSGDH) CA’s. In linear modelling cannabis use was significantly linked with anal stenosis, congenital hydrocephalus and Turner syndrome (ACT) and was significantly linked in borderline significant models (model P < 0.1) with microtia, microphthalmia, and transposition of the great vessels. At robust and mixed effects inverse probability weighted multivariable regression cannabis was related to 18 defects. 16/17 E-Values in spatial models were > 1.25 ranging up to 5.2 × 1013 making uncontrolled confounding unlikely.

Conclusions
These results suggest that population level CA’s react more strongly to small rises in cannabis use than tobacco or alcohol; cardiovascular, chromosomal, body wall and gastrointestinal CA’s rise significantly with small increases in cannabis use; that cannabis is a bivariate correlate of AVTPCDSGDH and ACT anomalies, is robust to adjustment for other substances; and is causal.
Evaluating motivational characteristics in vocational music education within the perspective of self-determination theory
Authors: Virkkula Esa 
Published: November 2020

AbstractThis article examines the influence of vocational music education workshops on the learning motivation of popular and jazz music students in a self-determination theory’s (SDT) framework. SDT illustrates that satisfying people’s universal psychological needs has a significant influence on well-being and learning. Psychological needs will become satisfied when the learner autonomously influences the choices and decisions of his or her learning. The learner feels then competent to act in the learning environment and receive the experiences related to it. The present article is based on a qualitative research project that examined 62 Finnish conservatory popular and jazz music students who participated in 11 music performance workshops with professional musicians in 2003–2011. The research data consists of (a) workshop plans and learning goals written by the students before the workshops and (b) reflective essays of experiences after the workshops. The data was analysed using theory-oriented content analyses. The students were responsible for the planning and implementation of music performances with professional musicians. Commitment to challenging performance projects with professional musicians motivated the students to try their best to develop their musicianship.
Utilizing technologies of fog computing in educational IoT systems: privacy, security, and agility perspective
Authors: Adel Amr 
Published: November 2020

AbstractFog computing architecture is referred to the architecture that is distributed over the geographical area. This architectural arrangement mainly focuses on physical and logical network elements, and software for the purpose of implementing proper network. Fog computing architecture allows the users to have a flexible communication and also ensures that the storage services are maintained efficiently for the purpose of managing the data. However, it has been observed that in the field of education fog computing architecture has gained huge importance due to its real time application feature. The main objective of the survey is to develop a systematic literature review for the technology of fog computing in the education IoT system. The survey will also focus on evaluating the essential factors that has a crucial role in the fields of education as well as investigating the limitation and findings associated with the fog computing technologies in educational systems from the perspective of privacy, security, and agility.
Recent advances in the intellectual property landscape of filamentous fungi
Authors: Hüttner Silvia , Johansson Anton , Gonçalves Teixeira Paulo , Achterberg Puck , Nair Ramkumar B. 
Published: November 2020

AbstractFor centuries, filamentous fungi have been used in the making of food and beverages, and for decades for the production of enzymes and pharmaceuticals. In the last decades, the intellectual property (IP) landscape for fungal technology has seen an ever increasing upward trend, introducing new and promising applications utilising fungi. In this review, we highlight fungi-related patent applications published during the last 5 years (2015–2020), identify the key players in each field, and analyse future trends. New developments in the field of fungal technology include the increased use of filamentous fungi as a food source (mycoprotein), using fungi as biodegradable materials, in wastewater treatment, in integrated biorefineries and as biological pest agents. Biotechnology companies in Europe and the US are currently leading when it comes to the number of patents in these areas, but Asian companies and research institutes, in particular in China, are becoming increasingly important players, for example in pesticide formulation and agricultural practices.
Annual and spatial variabilities in the acorn production of Quercus mongolica
Authors: Noh Jaesang , Kim Youngjin , Lee Jongsung , Cho Soyeon , Choung Yeonsook 
Published: November 2020

Abstract
Background
Genus Quercus is a successful group that has occupied the largest area of forest around the world including South Korea. The acorns are an important food source for both wild animals and humans. Although the reproductive characteristics of this genus are highly variable, it had been rarely studied in South Korea. Therefore, in Seoraksan and Odaesan National Parks (i) we measured the acorn production of Quercus mongolica, an overwhelmingly dominant species in South Korea, for 3 years (2017–2019), (ii) evaluated the spatial-temporal variation of acorn production, and (iii) analyzed the effects of oak- and site-related variables on the acorn production.

Results
The annual acorn production of Q. mongolica increased 36 times from 1.2 g m−2 in 2017 to 43.2 g m−2 in 2018, and decreased to 16.7 g m−2 in 2019, resulting in an annual coefficient of variation of 104%. The coefficient of spatial variation was high and reached a maximum of 142%, and the tree size was the greatest influencing factor. That is, with an increase in tree size, acorn production increased significantly (2018 F = 16.3, p < 0.001; 2019 F = 8.2, p < 0.01). Elevation and slope also significantly affected the production in 2019. However, since elevation and tree size showed a positive correlation (r = 0.517, p < 0.001), the increase in acorn production with increasing elevation was possibly due to the effect of tree size. The acorn production of Odaesan for 3 years was 2.2 times greater than that of Seoraksan. This was presumed that there are more distribution of thick oak trees and more favorable site conditions such as deep soil A-layer depth, high organic matter, and slower slopes.

Conclusion
As reported for other species of the genus Quercus, the acorn production of Q. mongolica showed large spatial and annual variations. The temporal variability was presumed to be a weather-influenced masting, while the spatial variability was mainly caused by oak tree size.
Dexamethasone as a bupivacaine adjuvant for ultrasound-guided interscalene brachial plexus block: a prospective randomized study
Authors: Badran Maha Abd el Fattah Metawie , Kamaly Ayman Mokhtar , Abdel Hamid Hadil Magdy , Mostafa Raham Hassan 
Published: November 2020

Abstract
Background
Finding adjuvants to local anesthetic used in interscalene block that could efficiently extend the analgesia duration has recently been the focus of researchers. The aim of the work was to determine whether the addition of perineural dexamethasone to bupivacaine in-ultrasound guided interscalene block would prolong the duration of sensory analgesia in patients undergoing shoulder surgery.

Results
This prospective, randomized, double-blinded study comprised 50 patients. They were randomly subdivided into 2 groups: group C [control] and group D [dexamethasone]. We noted a significant difference regarding the timing for the first rescue analgesia being shorter in group C than in group D with a P value < 0.001. Regarding postoperative analgesia, higher Ketolac consumption was noticed in group C than in group D. Patients from both groups showed excellent analgesic effects with VAS score less than 2 points up to 6 h postoperative then patients in group C had a higher VAS score compared to group D, and the difference was statistically significant (P value < 0.05). We also noticed an increase in the heart rate and mean arterial blood pressure in group C than in group D at 12 h and 24 h postoperatively.

Conclusion
We concluded that the addition of 8 mg of perineural dexamethasone to 30 ml of 0.5% bupivacaine showed improvement in the postoperative analgesia in shoulder surgery without obvious complications.
Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes?
Authors: Al-Ozairi Ebaa , Alsaeed Dalal , Alroudhan Dherar , Voase Nia , Hasan Amal , Gill Jason M R , Sattar Naveed , Welsh Paul , Gray Cindy M , Boonpor Jirapitcha , Celis-Morales Carlos , Gray Stuart R 
Published: November 2020

AbstractBackgroundWhilst skeletal muscles’ primary role is allowing movement, it has important metabolic roles, including in glycemic control. Indeed, evidence indicates that low muscle mass and function are associated with an increased risk of type 2 diabetes, highlighting its importance in the development of metabolic disease.MethodsIn this mini-review, we detail the evidence highlighting the importance of muscle in type 2 diabetes and the efficacy of resistance exercise in improving glycemic control alongside our approach to increase uptake of such exercise in people with type 2 diabetes. This summary is based in the authors’ knowledge of the filed supplemented by a Pubmed search using the terms “muscle,” “glycemic control,” “HbA1c,” “type 2 diabetes,” and “resistance exercise.”ResultsThe main strategy to increases muscle mass is to perform resistance exercise and, although the quality of evidence is low, such exercise appears effective in reducing Glycated Haemoglobin (HbA1c) in people with type 2 diabetes. However, to increase participation we need to improve our understanding of barriers and facilitators to such exercise. Current data indicate that barriers are similar to those reported for aerobic exercise, with additional resistance exercise specific barriers of looking to muscular, increase risk of cardiovascular event, having access to specialized equipment and knowledge of how to use it.ConclusionsThe development of simple resistance exercises that can be performed anywhere, that use little or no equipment and are effective in reducing HbA1c will be, in our opinion, key to increasing the number of people with type 2 diabetes performing resistance exercise.
Checking the Checkpoint Inhibitors: A Case of Autoimmune Diabetes After PD-1 Inhibition in a Patient with HIV
Authors: Hughes Michael S , Pietropaolo Massimo , Vasudevan Madhuri M , Marcelli Marco , Nguyen Ha 
Published: November 2020

Abstract
Immune checkpoint inhibitor–associated diabetes mellitus (ICI-DM) is a known immune-related adverse event (irAE) following treatment with programmed cell death protein 1 (PD-1), with a reported 0.9% incidence. We hereby present the first case, to our knowledge, of ICI-DM following ICI use in a human immunodeficiency virus (HIV) patient. In this case, a 48-year-old man with HIV stable on highly active antiretroviral therapy (HAART) was diagnosed with Hodgkin lymphoma and initiated treatment with the PD-1 inhibitor nivolumab. His lymphoma achieved complete response after 5 months. However, at month 8, he reported sudden polydipsia and polyuria. Labs revealed a glucose level of 764 mg/dL and glycated hemoglobin A1c (HbA1c) of 7.1%. Low C-peptide and elevated glutamic acid decarboxylase 65 (GAD65) antibody levels confirmed autoimmune DM, and he was started on insulin. Major histocompatibility complex class II genetic analysis revealed homozygous HLA DRB1*03-DQA1*0501-DQB1*02 (DR3-DQ2), which is a known primary driver of genetic susceptibility to type 1 DM. Autoimmune DM has been reported as an ICI-associated irAE. However, patients with immunocompromising conditions such as HIV are usually excluded from ICI trials. Therefore, little is known about such irAEs in this population. In this case, risk of ICI-DM as an irAE was likely increased by several factors including family history, a high-risk genetic profile, islet-related immunologic abnormalities, active lymphoma, and HIV infection with a possible immune reconstitution event. Clinicians should maintain a high index of suspicion for development of irAEs associated with ICI, particularly as use of these therapies broadens. Thorough investigation for presence of higher-risk features should be conducted and may warrant inclusion of pre-therapy genetic and/or autoantibody screening.