bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of short-term physical prehabilitation on psychophysiological parameters in patients undergoing coronary artery bypass grafting
Authors: Trubnikova О. A. , Tarasova I. V. , Mos’kin E. G. , Kupriyanova D. S. , Syrova I. D. , Argunova Yu. A. , Barbarash O. L. 
Published: December 2020

Aim.To study psychophysiological parameters in the patients undergoing coronary artery bypass grafting (CABG) who optionally underwent a short course of physical prehabilitation (PPR).Materials and Methods.We carried out a prospective randomised study which included 97 male patients (45 to 70 years) with coronary artery disease who underwent elected CABG; 47 of them additionally underwent a 5-7-day course of aerobic physical training before the surgery. Both patient groups were comparable with respect to the baseline clinicopathological features. Neuropsychological examination and electroencephalography was performed before the surgery and at 7th-10th day after CABG. Development of postoperative cognitive dysfunction (POCD) was considered as the study endpoint.Results.POCD developed in 58% patients with PPR and in 78.7% patients without PPR (p = 0.037); therefore, the risk of developing POCD in those who underwent PPR was lower (OR=0,39, р=0,045). Further, patients with PPR showed an increase in integral attention value relative to the preoperative state (p = 0.04) while those without PPR demonstrated a decrease in this cognitive parameter (p = 0.03). Integral attention value and general cognitive status remained higher in patients with PPR than in those without (p = 0.048 and p = 0.048, respectively) at 7th-10th day after CABG. The theta1 rhythm power increase was higher in patients without PPR at 7th-10th day after CABG (p = 0.01).Conclusion.The patients with a short preoperative course of PPR had better indicators of electrical cortical activity and higher integral cognitive value in the early postoperative period after CABG than those without training. Short course of PPR before CABG can increase the resistance of the brain to the intraoperative injury and may reduce the severity of the cognitive impairment after cardiac surgery. Indicators of brain electrical activity can be informative to evaluate the efficiency of cardiac rehabilitation
Comparative analysis of the foot position in children with symptomatic and asymptomatic flatfoot using the foot posture index (FPI-6)
Authors: Shabaldin N. A. , Shabaldin A. V. , Titov F. V. , Kokina V. A. 
Published: December 2020

Aim. To compare the foot position in asymptomatic children and those who received conservative or surgical because of flatfoot.Materials and Methods. We consecutively recruited three patient groups: 112 healthy children, 74 children with a pronation position, and 80 children with an overpronation position of the foot. The Foot Posture Index (FPI – 6) was used for the clinical examination. Visual and manual clinical tests were used to determine the mobility of the foot joints. X-ray was performed in a standard lateral projection with a load; if necessary, multislice computed tomography of the foot was performed.Results. Healthy children commonly have pronation position of the foot during the first 10 years of life, with the further normalisation of the posture. In patients receiving conservative treatment of foot pronation, normalisation of the foot position was considerably less pronounced than in healthy children. Further, in those with overpronation position, there were no age-dependent changes in the posture and surgery was the only efficient approach to correct the flatfoot.Conclusion. FPI-6 is a highly sensitive tool for clinical diagnosis of flatfoot. Moderate pronation has a more favorable prognosis than the overpronation position, which is not corrected during the body growth or by the conservative treatment. Yet, surgery is a safe and efficient approach to relieve the pain syndrome and treat the flatfoot deformity.
Efficiency of il-6 inhibitor (olokizumab) in suppressing inflammation in patients with moderate COVID-19 pneumonia
Authors: Ganyukova N. G. , Likstanov M. I. , Kosinova M. V. , Kushnir I. N. , Moses V. G. , Moses K. B. 
Published: December 2020

Aim. To study the efficiency of IL-6 inhibitor olokizumab in suppressing the inflammation and improving treatment outcomes in patients with moderate COVID-19 pneumonia. Materials and Methods. We enrolled 48 patients with confirmed COVID-19 pneumonia who had indications for the treatment with olokizumab. Treatment group (n = 29) included patients who received a single subcutaneous injection of olokizumab (0.4 mL, 160 mg/mL) while placebo group (n = 19) included those who did not receive the drug because of contraindications. Inflammatory markers (C-reactive protein, white blood cell count, lymphocyte count, ferritin and D-dimer) have been evaluated on the 1st and the 5th day after the administration of olokizumab. Efficiency of olokizumab was assessed by the treatment outcome and suppression of cytokine storm. Results. At the 5th day, SpO2 was 90% (88; 92-93) in both groups, yet none of the patients in the treatment group required a mechanical ventilation, in contrast to 21.1% patients in the placebo group (p = 0.001). Inflammatory parameters were also reduced in the treatment group according to the measurements of serum C-reactive protein (5.6 (1.8;13.5) and 23 (17;92.5) mg/L in the treatment and placebo group, respectively, p = 0.0002) and white blood cell count (5.9 (4.8;6.2) and 7.6 (6.6;12 )*109 /L in the treatment and placebo group, respectively, p=0.03). No statistically significant differences were registered regarding serum ferritin (325 (200; 700) and 215 (186; 526) ng/mL, p = 0.41), D-dimer (827 (378; 1940) and 1464 (677; 4600) ng FEU/mL, p = 0.16) and lymphocyte count (1.3 (0.8; 2.1) and 1.5 (1; 2.1)*109 /L, p =0.44). Death was registered in 3.5% and 21.1% of patients in the treatment and placebo group, respectively, (p = 0.05). Conclusion. Olokizumab ameliorated the progression of COVID-19 pneumonia, improved treatment outcomes and reduced systemic inflammation.
The neutrophil extracellular traps as a component of the tumor microenvironment
Authors: Kayukova Е. V. , Fefelova E. V. 
Published: December 2020

The stem cell mutations and modification of the tumor microenvironment are the main causes of cancer formation. The neutrophiles extracellular traps (NETs) are the components of the tumor microenvironment. NETs are web-like structures composed of nucleic acids, enzymes, cytoplasmic proteins, and bound pathogens. Currently the information on the pathogenetic role of NETs in the development of chronic noncommunicable diseases is contradictory. There is data of their carcinogenic effect. Aim. To determine the amount of NETs and the composition of the tumor microenvironment in the cervical smears in patients with precancerous diseases and cervical cancer. Material and Methods. The clinical group 1 - patients with precancer cervical diseases (n=10), the clinical group 2 – patients with cervical cancer III stage (n=14) were studied. The average age of patients was 38±8.26. The control group was formed of volunteers without cervical pathologies (n=10). Cervical smears were used as the material for the research. The study was compliant with the principles of WMA Declaration of Helsinki, 1964, rev. 2013 and was performed with consent of the Local Ethics Committee of Chita State Medical Academy. Cancer or dysplastic cells, normall cells, immune cells, NETs were counted in Feulgen stained cervical smears by the optical microscope. Results. There are reducing the proportion of healthy epithelial cells, increasing the pool of immune system cells and the appearance of the NETs in the cervical scraping during cervical cancerogenesis. NETs were visualized In 60% of cervical cancer patients. The statistically significant differences in the content of NF in cervical smears among the group of patients with precancerous diseases of the cervix and the control group did not determinated.Conclusion. Detection of the NETs in the cervical smears may be a new cytological sign of malignancy of the cervical epithelium. Detection of the NETs in the cervical tumor microenvironment smears may indicate their involvement in cervical carcinogenesis.
Analisis Permintaan Cabai Merah Besar di Kota Padang, Sumatra Barat
Authors: Hamidah Kurnia , Syahni Rahmat , Sari Rina 
Published: December 2020

Penelitian ini bertujuan untuk menganalisa pengaruh dari harga cabai merah besar, harga cabai merah keriting, harga bawang merah, dan terhadap permintaan cabai merah besar di Kota Padang pada periode 2009 - 2018. Penelitian ini menggunakan data sekunder yang berbentuk time series. Metode penelitian yang digunakan adalah Analisis Linear Berganda. Variabel yang dipakai dalam penelitian ini adalah Permintaan Cabai Merah Besar di Kota Padang (Y), Harga Cabai Merah Besar (X1), Harga Cabai Merah Keriting (X2), Harga Bawang Merah (X3), serta Pendapatan Perkapita kota Padang (X4). Hasil analisis menunjukkan bahwa Harga Cabai Merah Besar, Cabai Merah Keriting, Harga Bawang Merah memiliki pengaruh yang positif dan signifikan terhadap Permintaan Cabai Merah Besar di Kota Padang namun Pendapatan Perkapita Kota Padang tidak memiliki pengaruh terhadap Permintaan Cabai Merah Besar di Kota Padang
Traditional and Modern Concepts of Rhetoric: Six Peculiarities
Authors: HOVHANNISYAN Hovhannes 
Published: December 2020

The article explores the common denominators and differences of traditional and modern understandings of rhetoric. It reveals main tendencies of development of rhetoric as a field of theoretical knowledge and transformations of the problematics. The issue of interrelation between logical-content and extra-logical (psychological, aesthetic, ethical, linguistic, ritual) factors in traditional and modern concepts of rhetoric is discussed. The following thesis is substantiated that in modern concepts of rhetoric both the arsenal of tricks used and the area of operation are expanded to include other forms and manifestations of human communication in line with the individual-to-audience model.
It is argued that, unlike traditional rhetoric, which is largely monologue-based, modern concepts mostly implement rhetoric tricks in negotiation, debate, and competition situations.
The article analyzes the issue of correlation between oral public and direct speech on the one hand, and, on the other, written speech and mediated means of communication in the traditional and modern concepts of rhetoric.
The view is substantiated that in the modern system of rhetoric, much importance is attached to ethical questions, to the issues whether the means used are permissible or inadmissible in terms of effective communication norms.
The relations between the philosophical theory of rhetoric (general rhetoric) and its individual spheres are discussed.
Penerapan Good Environmental Governance pada Praktik Perdagangan Karbon di Proyek Katingan Mentaya
Authors: Sukadi Bimo Dwi Nur Romadhon , Pinatih Dewa Ayu Agung Intan , Sari Ni Putu Mirna 
Published: December 2020

The implementation of good governance by continuing to prioritize respect for the environment (good environmental governance) is very suitable to be applied during the environmental problems that occur recently. The implementation of good environmental governance in carbon trading practices in the Katingan Mentaya Project ishe collaboration between the government, private sector, and community, which becomes the main focus of this research. The division of power, duties and authority among the stakeholders is analyzed with 3 principles of good environmental governance. This study revealed an academic study related to “the increasing degree of power-sharing between state and market actors”, where the division of roles between the government and market actors in stage of expanding towards an ideal position. The government (KLHK) is still developing its role as a regulator, while market actor (PT. RMU) is still exploring its potential efforts based on the midst of environmental and community empowerment at Katingan Mentaya Project’s area. The existed of a statue or legal product that contains carbon trading mechanisms based on the principle of non-overlapping good environmental governance is very necessary for alleviating problems and obstacles that arise.
Keywords: Good Environmental Governance, Carbon Trading, Katingan Mentaya Project
Abstrak
Penyelenggaraan pemerintahan yang baik dengan tetap mengedepankan penghormatan terhadap lingkungan (good environmental governance) sangat sesuai untuk diterapkan di tengah permasalahan lingkungan yang kerap terjadi belakangan ini. Penerapan good environmental governance dalam praktik perdagangan karbon di Proyek Katingan Mentaya, yang merupakan kolaborasi antara pemerintah, swasta, dan masyarakat menjadi fokus utama dalam penelitian ini. Pembagian kekuasaan, tugas, dan wewenang di antara para pelaksana yang terlibat dianalisis dengan tiga prinsip good environmental governance. Penelitian ini mengungkapkan kajian akademik terkait “the increasing degree of power sharing between state and market actors”, yaitu pembagian peran antara pemerintah dan pelaku pasar dalam tahap berkembang (expanding) menuju posisi ideal. Pemerintah (KLHK) masih terus berkembang dalam perannya sebagai regulator dalam menciptakan kebijakan, sedangkan pihak swasta (PT. RMU) masih dalam tahap menggali potensi dengan tetap memperhatikan usaha yang berbasis lingkungan dan upaya pemberdayaan masyarakat di area Proyek Katingan Mentaya. Kehadiran suatu statue atau produk hukum yang memuat tentang mekanisme perdagangan karbon berdasarkan prinsip good environmental governance yang tidak tumpang tindih tentu saja sangat diperlukan, dalam mengentaskan permasalahan dan penghambat yang timbul.
Kata Kunci: Good Environmental Governance, Perdagangan Karbon, Proyek Katingan Mentaya
Implementasi Sistem Merit pada Aparatur Sipil Negara di Indonesia
Authors: Chairiah Anggita , S Ariski , Nugroho Agus , Suhariyanto Adi 
Published: December 2020

High performance and competency are the demands that nowadays must be owned by State Civil Apparatus known as ASN. Those demands can be achieved if the human resources' screening process is carried out lawfully and correctly by procedures. This article aims to examine the management of State Civil Apparatus in Indonesia using the merit system theory based on several phenomena. The data were analyzed using qualitative techniques, namely a descriptive phenomenological analysis. The discussion focuses on the development and particular phenomenon of the merit system in Indonesia's current situation, starting from the beginning of the selection and recruitment process, the placement of ASN, and implementing a merit system based on competency. Research result showed that the implementation of the merit system in Indonesia has not yet been thoroughly carried out based on the right procedures. More importantly, to become a dynamic governance also requires firm awareness of all stakeholders' responsibility, which is the primary key to executing a merit system in Indonesia. However, the improvement of supervision also needs to be done, especially by KASN, to optimize the merit system's implementation.
Keywords: Merit System, State Civil Apparatus (ASN), Performance Appraisal, Human Resource Management
Abstrak
Kinerja dan kompetensi tinggi merupakan salah satu tuntutan yang harus dimiliki ASN saat ini. Hal ini bisa diwujudkan jika proses penyaringan sumber daya manusia yang unggul dilakukan dengan jujur dan benar sesuai dengan prosedur. Artikel ini bertujuan untuk mengkaji manajemen Aparatur Sipil Negara di Indonesia menggunakan teori sistem merit berdasarkan beberapa fenomena yang ada. Data dianalisis menggunakan teknik analisis data kualitatif, yakni descriptive phenomenological analysis. Pada pembahasan fokus penelitian, dipaparkan pelaksanaan serta beberapa fenomena penerapan sistem merit pada ASN di Indonesia saat ini dari awal proses seleksi dan rekrutmen, penempatan ASN hingga penerapan sistem merit berdasarkan kompetensi. Hasil penelitian menemukan bahwa penerapan sistem merit di Indonesia masih belum sepenuhnya dilakukan sesuai prosedur. Kunci sukses lainnya, agar menjadi dynamic governance diperlukan kesadaran penuh dari semua pemangku kepentingan dalam menerapkan sistem merit di Indonesia. Namun, peningkatan pengawasan juga perlu dilakukan terutama oleh KASN agar implementasi sistem merit dapat optimal.
Kata Kunci: Sistem Merit, Aparatur Sipil Negara (ASN), Penilaian Kinerja, Manajemen Sumber Daya Manusia
Penerapan Kebijakan Sistem Merit: Praktik Terbaik di Lembaga Administrasi Negara
Authors: Suryanto Adi , Darto Mariman 
Published: December 2020

The implementation of the merit system policy in National Institute of Public Administration (NIPA) since 2015 has recently gained a positive recognition. In 2019, NIPA has got an excellent rating in the Merit System Index published by the Commission of State Civil Apparatus (KASN). The purpose of this research is to explore NIPA’s experience in implementing the merit system processes, what has been done and how to do it. Through an explorative-qualitative approach, data were collected by interviewing key informants as well as document analysis of the merit system implementation process for the last 5 years (2015-2020) and using participation observer technique. The result showed that NIPA has consistently implemented the merit system according to its principles and regulation during its implementation. It is also found that top leaders’ commitment has played a dominant and significant factor in the successful merit system implementation.
Keywords: Merit System, Civil Servant, Professionalism
Abstrak
Sistem merit yang diterapkan di Lembaga Administrasi Negara (LAN) sejak tahun 2015 lalu telah mendapatkan pengakuan dari Pemerintah. Pada tahun 2019 LAN meraih predikat sangat baik dalam penilaian Indeks Sistem Merit (Merit System Index) yang dilakukan oleh Komisi Aparatur Sipil Negara (KASN). Tujuan penelitian ini adalah untuk mengekplorasi lebih jauh tentang mengapa LAN menerapkan sistem merit, apa saja yang telah dilakukan, dan bagaimana melakukannya. Dengan menggunakan pendekatan kualitatif-eksploratif, pengumpulan berbagai data/informasi pendukung sejak diterapkannya sistem merit (2015-2020), wawancara terbatas dengan para pengambil kebijakan dilakukan dan menggunakan teknik participation observer. Hasilnya bahwa penerapan sistem merit di LAN dilakukan sesuai dengan prinsip dan tahapan kebijakan yang ada. Komitmen pimpinan dan konsistensi dalam penerapan kebijakan sistem merit menjadi faktor determinan.
Kata Kunci: Sistem Merit, Pegawai Negeri Sipil, Profesionalisme
Kinematic and kinetic analyses of the gait of horses wearing novel legwear for variably limiting extension of the metacarpophalangeal joint
Authors: St. George Lindsay B. , Pugliese Brenna R. , Hobbs Sarah J. , Brisbois Abby L. , Sinclair Jonathan K. , Kirker-Head Carl A. 
Published: December 2020

Abstract

OBJECTIVE
To investigate the effects of novel legwear designed to limit metacarpophalangeal joint (MCPJ) extension and redirect loading forces from the flexor apparatus through analyses of 2-D kinematic and kinetic data.

ANIMALS
6 adult horses without musculoskeletal disease.

PROCEDURES
Horses were subjected to 4 treatments: control (no legwear), inactive legwear (unlimited legwear extension), and active legwear with mild (30°) and moderate (20°) legwear extension limitation. Two-dimensional kinematic data were collected for the right forelimb (FL) during walk and trot and from leading and trailing FLs during canter on a treadmill. Ground reaction force (GRF) data were collected from FLs during overground walk and trot. Peak MCPJ angle and angular velocity were calculated from kinematic data, and peak force and average loading rate were calculated from vertical GRF data during the stance phase of the gait. Interactions between gait and treatment were determined via ANOVA.

RESULTS
Interactions between gait and treatment for peak MCPJ angle were significant. Significant reductions in MCPJ angle were noted between the control treatment and legwear with moderate extension limitation for trot and canter (leading and trailing FL) and between inactive legwear and legwear with moderate extension limitation for trot and leading FL during canter. Interactions among peak MCPJ angular velocity, peak vertical GRF, and average loading rate of the vertical GRF showed nonsignificance.

CONCLUSIONS AND CLINICAL RELEVANCE
Significant reductions in MCPJ extension without significant alterations to peak vertical GRF suggested the legwear's ability to redistribute internal forces. Findings suggested that the legwear may be beneficial for horses rehabilitating from flexor apparatus injuries.
Alterations in pregnancy-associated glycoprotein concentrations of pregnant sheep experimentally infected with bovine viral diarrhea virus
Authors: Lear Andrea , Pohler Ky , Sula Mee-Ja M. , Kiupel Matti , Mulon Pierre-Yves , Caldwell Marc 
Published: December 2020

Abstract

OBJECTIVE
To compare pregnancy-associated glycoprotein 1 (PAG1) concentrations in maternal (jugular vein) and fetal (uterine vein) circulations and amniotic fluid samples between pregnant ewes that were and were not experimentally infected with bovine viral diarrhea virus (BVDV).

ANIMALS
11 healthy pregnant yearling ewes.

PROCEDURES
Before study initiation, all ewes were naïve to BVDV and confirmed pregnant by transabdominal ultrasonography at approximately 60 days of gestation. At 65 days of gestation, ewes were intranasally inoculated with a noncytopathic BVDV type 1b strain (concentration, 107 TCID50/mL; 2 mL/nostril; n = 6) or an equal volume of BVDV-free viral culture medium (control; 5). A blood sample was collected for measurement of PAG1 concentration before inoculation. At 80 days of gestation, each ewe was anesthetized and underwent an ovariohysterectomy. While sheep were anesthetized, blood samples from the jugular and uterine veins and an amniotic fluid sample were collected for measurement of PAG1 concentration. Fetal tissues underwent real-time PCR analysis for BVDV RNA, and placental specimens underwent histologic evaluation and immunohistochemical staining for BVDV antigen.

RESULTS
At 80 days of gestation, BVDV RNA in fetal tissues and mild placentitis were detected in 5 of 6 BVDV-inoculated ewes. Mean PAG1 concentrations in the maternal and fetal circulations of BVDV-inoculated ewes were significantly less than those in control ewes. Mean amniotic fluid PAG1 concentration did not differ significantly between the 2 groups.

CONCLUSIONS AND CLINICAL RELEVANCE
Concentration of PAG1 in the maternal circulation may be a useful biomarker for determining placental health in sheep after viral infection of the reproductive tract.