bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and functional characaterization of the novel odorant-binding protein geneAccOBP10fromApis cerana cerana
Authors: Guo Dezheng , Hao Cuihong , Cui Xuepei , Wang Ying , Liu Zhenguo , Xu Baohua , Guo Xingqi 
Published: September 2020

AbstractOdorant-binding proteins (OBPs) play an important role in odour perception and transport in insects. However, little is known about whether OBPs perform other functions in insects, particularly in Apis cerana cerana. Within this study, an OBP gene (AccOBP10) was isolated and identified from A. c. cerana. Both homology and phylogenetic relationship analyses indicated that the amino acid sequence of AccOBP10 had a high degree of sequence identity with other members of the gene family. Analysis of quantitative real-time PCR (qRT-PCR) showed that AccOBP10 mRNA was expressed at higher levels in the venom gland than in other tissues. The mRNA transcript expression of AccOBP10 was upregulated by low temperature (4°C), hydrogen peroxide (H2O2), pyridaben, methomyl and imidacloprid but downregulated by heat (42°C), ultraviolet light, vitamin C, mercuric chloride, cadmium chloride, paraquat and phoxim. Expression of AccOBP10 under abiotic stress was analysed by western blotting, and the results were consistent with those of qRT-PCR. And as a further study of AccOBP10 function, we demonstrated that knockdown of AccOBP10 by RNA interference could slightly increase the expression levels of some stress-related genes. Collectively, these results suggest that AccOBP10 is mainly involved in the response to stress conditions.
A Descriptive Study of High-Frequency Trade and Quote Option Data*
Authors: Andersen Torben , Archakov Ilya , Grund Leon , Hautsch Nikolaus , Li Yifan , Nasekin Sergey , Nolte Ingmar , Pham Manh Cuong , Taylor Stephen , Todorov Viktor 
Published: September 2020

Abstract
This paper provides a guide to high-frequency option trade and quote data disseminated by the Options Price Reporting Authority (OPRA). We present a comprehensive overview of the U.S. option market, including details on market regulation and the trading processes for all 16 constituent option exchanges. We review the existing literature that utilizes high-frequency options data, summarizes the general structure of the OPRA dataset, and presents a thorough empirical description of the observed option trades and quotes for a selected sample of underlying assets that contains more than 25 billion records. We outline several types of irregular observations and provide recommendations for data filtering and cleaning. Finally, we illustrate the usefulness of the high-frequency option data with two empirical applications: option-implied variance estimation and risk-neutral density estimation. Both applications highlight the rich information content of the high-frequency OPRA data.
Holography: application to high-resolution imaging
Authors: Kawasaki Takeshi , Takahashi Yoshio , Tanigaki Toshiaki 
Published: September 2020

Abstract
Electron holography was invented for correcting aberrations of the lenses of electron microscopes. It was used to observe the atomic arrangements in crystals after decades of research. Then it was combined with a hardware aberration corrector to enable high-resolution and high-precision analysis. Its applications were further extended to magnetic observations with sub-nanometer resolution. High-resolution electron holography has become a powerful technique for observing electromagnetic distributions in functional materials.
Pantomime as the original human-specific communicative system
Authors: Zlatev Jordan , Żywiczyński Przemysław , Wacewicz Sławomir 
Published: September 2020

AbstractWe propose reframing one of the key questions in the field of language evolution as what was the original human-specific communicative system? With the help of cognitive semiotics, first we clarify the difference between signals, which characterize animal communication, and signs, which do not replace but complement signals in human communication. We claim that the evolution of bodily mimesis allowed for the use of signs, and the social-cognitive skills needed to support them to emerge in hominin evolution. Neither signs nor signals operate single-handedly, but as part of semiotic systems. Communicative systems can be either monosemiotic or polysemiotic—the former consisting of a single semiotic system and the latter, of several. Our proposal is that pantomime, as the original human-specific communicative system, should be characterized as polysemiotic: dominated by gesture but also including vocalization, facial expression, and possibly the rudiments of depiction. Given that pantomimic gestures must have been maximally similar to bodily actions, we characterize them as typically (1) dominated by iconicity, (2) of the primary kind, (3) involving the whole body, (4) performed from a first-person perspective, (5) concerning peripersonal space, and (6) using the Enacting mode of representation.
When the tune shapes morphology: The origins of vocatives
Authors: Sóskuthy Márton , Roettger Timo B 
Published: September 2020

AbstractMany languages use pitch to express pragmatic meaning (henceforth ‘tune’). This requires segmental carriers with rich harmonic structure and high periodic energy, making vowels the optimal carriers of the tune. Tunes can be phonetically impoverished when there is a shortage of vowels, endangering the recovery of their function. This biases sound systems towards the optimisation of tune transmission by processes such as the insertion of vowels. Vocative constructions—used to attract and maintain the addressee’s attention—are often characterised by specific tunes. Many languages additionally mark vocatives morphologically. In this article, we argue that one potential pathway for the emergence of vocative morphemes is the morphological re-analysis of tune-driven phonetic variation that helps to carry pitch patterns. Looking at a corpus of 101 languages, we compare vocatives to structural case markers in terms of their phonological make-up. We find that vocatives are often characterised by additional prosodic modulation (vowel lengthening, stress shift, tone change) and contain substantially fewer consonants, supporting our hypothesis that the acoustic properties of tunes interact with segmental features and can shape the emergence of morphological markers. This fits with the view that the efficient transmission of information is a driving force in the evolution of languages, but also highlights the importance of defining ‘information’ broadly to include pragmatic, social, and affectual components alongside propositional meaning.
A Possible Case of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Newborn With Positive Placental In Situ Hybridization of SARS-CoV-2 RNA
Authors: Alamar Ihab , Abu-Arja Mohammad H , Heyman Taryn , Roberts Drucilla J , Desai Niyati , Narula Pramod , Dygulska Beata 
Published: September 2020

Abstract
Little is known about the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the coronavirus disease 2019 (COVID-19) on pregnant mothers and their infants. Moreover, there is no definitive evidence that SARS CoV- 2 can be vertically transmitted from an infected mother to the unborn fetus.
A case of esophageal rupture caused by long-term exposure to vinegar and resolved by damage control strategies
Authors: Okura Tomohiro , Inaba Mototaka , Yasuhara Isao , Kataoka Masafumi 
Published: September 2020

Abstract
A 75-year-old woman had the habit of drinking vinegar. She had emergent transport to our hospital because of vomiting and unconsciousness. The patient underwent emergency surgery for esophageal rupture and septic shock. Intraoperatively, a 25 mm perforated area was found, and the visible esophageal mucosa was black. Because the suture closure or anastomosis was difficult and the shock was prolonged, she was placed in the intensive care unit after undergoing resection of the thoracic esophagus and thoracic drainage. Fifteen hours after the first surgery, we performed external esophagostomy and enterostomy. The third surgery was a retrothoracic cervical esophagogastric anastomosis, and reconstructive surgery was performed 60 days after the first surgery. Prolonged exposure to vinegar may have resulted in esophageal mucosal necrosis. This is a valuable case in which the esophageal mucosa was necrotic, and we performed esophagectomy and reconstruction as a damage control strategy to save her life.
A case of infiltrative cecal endometriosis with appendiceal obliteration and lymph node involvement
Authors: Law Yi Ying , Patel Rhea , Yorke Rebecca , Bailey Harold R , Van Eps Jeffrey L 
Published: September 2020

Abstract
Endometriosis is a clinical condition with a wide spectrum of severity, and a subset that includes intestinal involvement that may even mimic malignancy, making non-surgical diagnosis difficult. Cecal endometriosis is a rare finding among intestinal endometriosis. We report on 33-year-old woman with ileocecal endometriosis presenting as endoscopic prolapse of the ileocecal valve associated with a mass on cross-sectional imaging. The diagnosis was suggested intraoperatively by peritoneal endometrioma and obliteration of the appendix during laparoscopic right hemicolectomy. Pathological review demonstrated extensive submucosal, infiltrative endometriosis with mass effect and lymph node involvement. This case highlights the difficulty in preoperative diagnosis of intestinal endometriosis and the wide-ranging potential tissue effects in cases of infiltrative disease.
To do or not to do: prolapsed, bleeding, rectal polyp, a dilemma in austere circumstances
Authors: Pandya Bharati , Golmei Jason , Henriques Merlyn S , Dawar Anil 
Published: September 2020

Abstract
Polyps are defined as abnormal growth of tissue from a mucosal surface. Rectal polyps are the most common (2%) cause of gastro-intestinal bleed in children below 10 years. In adults, a rectal polyp presenting as an emergency with irreducible prolapse and massive bleeding causing severe anemia is seldom seen. We present one such case in which surgery was performed under austere circumstances before any investigations, as a life saving measure.
Improving soybean seed oil without poor agronomics
Authors: Alfonso Miguel 
Published: September 2020

This article comments on:Lakhssassi N, Zhou Z, Liu S, Piya S, Cullen MA, El Baze A, Knizia D, Patil GB, Badad O, Embaby MG, Meksem J, Lakhssassi A, Ghazaleh A, Hewezi T, Meksem K. 2020. Soybean TILLING-by-sequencing+ reveals the role of novel GmSACPD members in unsaturated fatty acid biosynthesis while maintaining healthy nodules. Journal of Experimental Botany 71, 6969–6987.
Discrimination against Roma: Evidence from two survey experiments in Norway
Authors: Falck Runa 
Published: September 2020

AbstractNorway has a history of tough assimilation of the first migration of Roma people, known as the Tater/Romani people. The state introduced laws that discriminated against the Tater/Romani people. This article traces the international and national developments from discriminatory laws to laws against discrimination in Norway. With the recent appearance of immigrant Roma from Eastern Europe, Roma are once again on the political agenda of West European countries. Despite the many laws against discrimination that are now in place, this article demonstrates that the public still discriminates against Roma people. Two survey experiments reveal that the Roma are being directly discriminated against within the Norwegian society and indirectly discriminated against compared to other European Economic Area (EEA) immigrants. The article suggests that this could be related to a history of antiziganism in society. Furthermore, it appears that such attitudes are not easily changed by laws but demands broad social mobilisation.
Splinting in Carpal Tunnel Syndrome: The Optimal Duration
Authors: Gatheridge Michele A , Sholty Elsa A , Inman Alexander , Pattillo Meghan , Mindrup Frank , Sanderson Dawn L 
Published: September 2020

Abstract

Introduction
The purpose of this study was to evaluate optimal neutral wrist splint duration in treatment-naive mild and mild to moderate carpal tunnel syndrome (CTS). Neutral wrist splinting is a conservative treatment for CTS; however, no clear guidelines exist for how long splinting should be prescribed for optimal outcomes.

Materials and Methods
In this prospective clinical trial subjects were assigned to wear a neutral wrist splint for 6 (group A) or 12 weeks (group B). Symptom and functional outcomes were assessed by questionnaire at baseline, 6 and 12 weeks. Median nerve sensory and motor latencies were recorded at baseline and 12 weeks. Pretreatment, midtreatment, and posttreatment measures were compared within and between treatment groups where applicable. This study was approved by the United States Air Force Academy institutional review board.

Results
A total of 30 subjects (37 hands) were randomized to 2 treatment groups. Mean symptom severity and median sensory peak latency significantly improved in both groups at 12 weeks, without a significant difference between groups. Mean functional severity significantly improved only in group A.

Conclusion
Neutral wrist splint for 6 weeks resulted in better clinical improvements in patients with untreated mild and mild to moderate CTS. There was no additional benefit in extending splinting 6 additional weeks. This is the first study to compare duration of wrist splint use beyond 8 weeks. A larger sample size is needed to identify the reason for lack of functional improvement in group B. Long-term follow-up of this cohort will be helpful to determine the natural history of initial wrist splint use.
False-positive galactomannan antigen testing in pulmonary nocardiosis
Authors: Haran Arnon , Temper Violeta , Assous Marc , Bergel Michael , Chahanian Noga , Elinav Hila , Korem Maya 
Published: September 2020

Abstract

Early diagnosis of invasive aspergillosis (IA) is facilitated by detection of galactomannan (GM) in serum and bronchoalveolar lavage fluid (BALF) using an enzyme-linked immunosorbent assay (ELISA). Although accurate, false positive results have been reported with these tests in numerous contexts. We report for the first time the occurrence of false positive GM ELISA due to nocardiosis, initially in a clinical sample of BALF from a patient with pulmonary nocardiosis, and subsequently corroborated by in vitro reactivity of 26% of tested isolates. Since patients at risk for IA are also at risk for nocardiosis, this finding has important clinical implications.

Lay Summary
Early diagnosis of aspergillosis has been facilitated by the routine use of antibody-based detection of galactomannan in various bodily fluids. We report for the first time the occurrence of false positive results of this assay in the context of nocardiosis.
Accretion of galaxy groups into galaxy clusters
Authors: Benavides José A , Sales Laura V , Abadi Mario G 
Published: September 2020

ABSTRACT
We study the role of group infall in the assembly and dynamics of galaxy clusters in ΛCDM. We select 10 clusters with virial mass M200 ∼ 1014 $\rm M_\odot$ from the cosmological hydrodynamical simulation Illustris and follow their galaxies with stellar mass M⋆ ≥ 1.5 × 108 $\rm M_\odot$. A median of ${\sim}38{{\ \rm per\ cent}}$ of surviving galaxies at z = 0 is accreted as part of groups and did not infall directly from the field, albeit with significant cluster-to-cluster scatter. The evolution of these galaxy associations is quick, with observational signatures of their common origin eroding rapidly in 1–3 Gyr after infall. Substructure plays a dominant role in fostering the conditions for galaxy mergers to happen, even within the cluster environment. Integrated over time, we identify (per cluster) an average of 17 ± 9 mergers that occur in infalling galaxy associations, of which 7 ± 3 occur well within the virial radius of their cluster hosts. The number of mergers shows large dispersion from cluster to cluster, with our most massive system having 42 mergers above our mass cut-off. These mergers, which are typically gas rich for dwarfs and a combination of gas rich and gas poor for M⋆ ∼ 1011 $\rm M_\odot$, may contribute significantly within ΛCDM to the formation of specific morphologies, such as lenticulars (S0) and blue compact dwarfs in groups and clusters.
High-eccentricity migration of planetesimals around polluted white dwarfs
Authors: O’Connor Christopher E , Lai Dong 
Published: September 2020

ABSTRACT
Several white dwarfs (WDs) with atmospheric metal pollution have been found to host small planetary bodies (planetesimals) orbiting near the tidal disruption radius. We study the physical properties and dynamical origin of these bodies under the hypothesis that they underwent high-eccentricity migration from initial distances of several astronomical units. We examine two plausible mechanisms for orbital migration and circularization: tidal friction and ram-pressure drag in a compact disc. For each mechanism, we derive general analytical expressions for the evolution of the orbit that can be rescaled for various situations. We identify the physical parameters that determine whether a planetesimal’s orbit can circularize within the appropriate time-scale and constrain these parameters based on the properties of the observed systems. For tidal migration to work, an internal viscosity similar to that of molten rock is required, and this may be naturally produced by tidal heating. For disc migration to operate, a minimal column density of the disc is implied; the inferred total disc mass is consistent with estimates of the total mass of metals accreted by polluted WDs.
Wray 15-906: a candidate luminous blue variable discovered with WISE, Herschel, and SALT
Authors: Maryeva O V , Gvaramadze V V , Kniazev A Y , Berdnikov L N 
Published: September 2020

ABSTRACT
We present the results of study of the Galactic candidate luminous blue variable Wray 15-906, revealed via detection of its infrared circumstellar shell (of ≈2 pc in diameter) with the Wide-field Infrared Survey Explorer and the Herschel Space Observatory. Using the stellar atmosphere code cmfgen and the Gaia parallax, we found that Wray 15-906 is a relatively low-luminosity, $\log (L/\rm \, L_\odot)\approx 5.4$, star of temperature of 25 ± 2 kK, with a mass-loss rate of ${\approx}3\times 10^{-5} \, \rm \, M_\odot \, {\rm yr}^{-1}$, a wind velocity of $280\pm 50 \, {\rm \, km\, s^{-1}}$, and a surface helium abundance of 65 ± 2 per cent (by mass). In the framework of single-star evolution, the obtained results suggest that Wray 15-906 is a post-red supergiant star with initial mass of ${\approx}25 \, \rm \, M_\odot$ and that before exploding as a supernova it could transform for a short time into a WN11h star. Our spectroscopic monitoring with the Southern African Large Telescope does not reveal significant changes in the spectrum of Wray 15-906 during the last 8 yr, while the V-band light curve of this star over years 1999–2019 shows quasi-periodic variability with a period of ≈1700 d and an amplitude of ≈0.2 mag. We estimated the mass of the shell to be $2.9\pm 0.5 \, \rm \, M_\odot$ assuming the gas-to-dust mass ratio of 200. The presence of such a shell indicates that Wray 15-906 has suffered substantial mass-loss in the recent past. We found that the open star cluster C1128−631 could be the birth place of Wray 15-906 provided that this star is a rejuvenated product of binary evolution (a blue straggler).
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
Authors: Shao Zhengping , Lee Brian J , Rouleau-Turcotte Élise , Langelier Marie-France , Lin Xiaohui , Estes Verna M , Pascal John M , Zha Shan 
Published: September 2020

Abstract
DNA breaks recruit and activate PARP1/2, which deposit poly-ADP-ribose (PAR) to recruit XRCC1-Ligase3 and other repair factors to promote DNA repair. Clinical PARP inhibitors (PARPi) extend the lifetime of damage-induced PARP1/2 foci, referred to as ‘trapping’. To understand the molecular nature of ‘trapping’ in cells, we employed quantitative live-cell imaging and fluorescence recovery after photo-bleaching. Unexpectedly, we found that PARP1 exchanges rapidly at DNA damage sites even in the presence of clinical PARPi, suggesting the persistent foci are not caused by physical stalling. Loss of Xrcc1, a major downstream effector of PAR, also caused persistent PARP1 foci without affecting PARP1 exchange. Thus, we propose that the persistent PARP1 foci are formed by different PARP1 molecules that are continuously recruited to and exchanging at DNA lesions due to attenuated XRCC1-LIG3 recruitment and delayed DNA repair. Moreover, mutation analyses of the NAD+ interacting residues of PARP1 showed that PARP1 can be physically trapped at DNA damage sites, and identified H862 as a potential regulator for PARP1 exchange. PARP1-H862D, but not PARylation-deficient PARP1-E988K, formed stable PARP1 foci upon activation. Together, these findings uncovered the nature of persistent PARP1 foci and identified NAD+ interacting residues involved in the PARP1 exchange.
Duplex formation in a G-quadruplex bulge
Authors: Ngoc Nguyen Thi Quynh , Lim Kah Wai , Phan Anh Tuân 
Published: September 2020

Abstract
Beyond the consensus definition of G-quadruplex-forming motifs with tracts of continuous guanines, G-quadruplexes harboring bulges in the G-tetrad core are prevalent in the human genome. Here, we study the incorporation of a duplex hairpin within a bulge of a G-quadruplex. The NMR solution structure of a G-quadruplex containing a duplex bulge was resolved, revealing the structural details of the junction between the duplex bulge and the G-quadruplex. Unexpectedly, instead of an orthogonal connection the duplex stem was observed to stack below the G-quadruplex forming a unique quadruplex–duplex junction. Breaking up of the immediate base pair step at the junction, coupled with a narrowing of the duplex groove within the context of the bulge, led to a progressive transition between the quadruplex and duplex segments. This study revealed that a duplex bulge can be formed at various positions of a G-quadruplex scaffold. In contrast to a non-structured bulge, the stability of a G-quadruplex slightly increases with an increase in the duplex bulge size. A G-quadruplex structure containing a duplex bulge of up to 33 nt in size was shown to form, which was much larger than the previously reported 7-nt bulge. With G-quadruplexes containing duplex bulges representing new structural motifs with potential biological significance, our findings would broaden the definition of potential G-quadruplex-forming sequences.