bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Analysis of Prevalence of Triple-Negative Breast Cancer and Its Clinical Features at Incidence in Indian Patients With Breast Cancer
Authors: Kulkarni Apurv , Kelkar Devaki A. , Parikh Nidhi , Shashidhara Lingadahalli S. , Koppiker Chaitanyanand B. , Kulkarni Madhura 
Published: July 2020

PURPOSEBreast cancer is the most common cancer in women in India, with higher incidence rates of aggressive subtypes, such as triple-negative breast cancer (TNBC).METHODSA systematic review was performed to compute pooled prevalence rates of TNBC among patients with breast cancer, and clinical features at presentation were systematically compared with non-TNBC in an Indian cohort of 20,000 patients.RESULTSCombined prevalence of TNBC among patients with breast cancer was found to be on the higher side (27%; 95% CI, 24% to 31%). We found that the estrogen receptor (ER) expression cutoff used to determine ER positivity had an influence on the pooled prevalence and ranged from 30% (ER/progesterone receptor [PR] cut ff at 1%) to 24% (ER/PR cutoff at 10%). Odds for TNBC to present in the younger age-group were significantly higher (pooled odds ratio [OR], 1.35; 95% CI, 1.08 to 1.69), with a significantly younger mean age of incidence (weighted mean difference, −2.75; 95% CI, −3.59 to −1.92). TNBC showed a significantly higher odds of presenting with high grade (pooled OR, 2.57; 95% CI, 2.12 to 3.12) and lymph node positivity (pooled OR, 1.39; 95% CI, 1.21 to 1.60) than non-TNBC.CONCLUSIONSystematic review and meta-analysis of 34 studies revealed a high degree of heterogeneity in prevalence of TNBC within Indian patients with breast cancer, yet pooled prevalence of TNBC is high in India. High proportions of patients with TNBC present with aggressive features, such as high grade and lymph node positivity, compared with patients without TNBC. We emphasize the need for standardized methods for accurate diagnosis in countries like India.
Evaluation of Omics-Based Strategies for the Management of Advanced Lung Cancer
Authors: Salgia Ravi , Mambetsariev Isa , Pharaon Rebecca , Fricke Jeremy , Baroz Angel Ray , Hozo Iztok , Chen Chen , Koczywas Marianna , Massarelli Erminia , Reckamp Karen , Djulbegovic Benjamin 
Published: July 2020

PURPOSE: Omic-informed therapy is being used more frequently for patients with non–small-cell lung cancer (NSCLC) being treated on the basis of evidence-based decision-making. However, there is a lack of a standardized framework to evaluate those decisions and understand the association between omics-based management strategies and survival among patients. Therefore, we compared outcomes between patients with lung adenocarcinoma who received omics-driven targeted therapy versus patients who received standard therapeutic options. PATIENTS AND METHODS: This was a retrospective study of patients with advanced NSCLC adenocarcinoma (N = 798) at City of Hope who received genomic sequencing at the behest of their treating oncologists. A thoracic oncology registry was used as a clinicogenomic database to track patient outcomes. RESULTS: Of 798 individuals with advanced NSCLC (median age, 65 years [range, 22-99 years]; 60% white; 50% with a history of smoking), 662 patients (83%) had molecular testing and 439 (55%) received targeted therapy on the basis of the omic-data. A fast-and-frugal decision tree (FFT) model was developed to evaluate the impact of omics-based strategy on decision-making, progression-free survival (PFS), and overall survival (OS). We calculated that the overall positive predictive value of the entire FFT strategy for predicting decisions regarding the use of tyrosine kinase inhibitor–based targeted therapy was 88% and the negative predictive value was 96%. In an adjusted Cox regression analysis, there was a significant correlation with survival benefit with the FFT omics-driven therapeutic strategy for both PFS (hazard ratio [HR], 0.56; 95% CI, 0.42 to 0.74; P < .001) and OS (HR, 0.51; 95% CI, 0.36 to 0.71; P < .001) as compared with standard therapeutic options. CONCLUSION: Among patients with advanced NSCLC who received care in the academic oncology setting, omics-driven therapy decisions directly informed treatment in patients and was correlated with better OS and PFS.
Decline in Muscle Strength and Performance Predicts Fracture Risk in Elderly Women and Men
Authors: Alajlouni Dima , Bliuc Dana , Tran Thach , Eisman John A , Nguyen Tuan V , Center Jacqueline R 
Published: July 2020

Abstract

Context
Muscle strength and performance are associated with fractures. However, the contribution of their rate of decline is unclear.

Objective
To assess the independent contribution of the rate of decline in muscle strength and performance to fracture risk.

Design, Setting, and Participants
Community-dwelling women (n = 811) and men (n = 440) aged 60 years or older from the prospective Dubbo Osteoporosis Epidemiology Study followed from 2000 to 2018 for incident fracture. Clinical data, appendicular lean mass/height2 (ht)2, bone mineral density, quadricep strength/ht (QS), timed get-up-and-go (TGUG), 5 times repeated sit-to-stand (5xSTS), and gait speed (GS) measured biennially. Rates of decline in muscle parameters were calculated using ordinary least squares regression and fracture risk was assessed using Cox’s models.

Main Outcome
Incident low-trauma fracture ascertained by x-ray report.

Results
Apart from lean mass in women, all muscle parameters declined over time. Greater rates of decline in physical performance were associated with increased fracture risk in women (Hazard ratios [HRs] ranging from 2.1 (95% CI: 1.5–2.9) for GS to 2.7 (95% CI: 1.9–3.6) for 5xSTS, while in men only the decline in GS was associated with fracture risk (HR: 3.4 [95% CI: 1.8–6.3]). Baseline performance and strength were also associated with increased fracture risk in men (HRs ranging from 1.8 (95% CI: 1.1–3.0) for QS to 2.5 (95% CI: 1.5–4.1) for TGUG, but not in women.

Conclusion
Rate of decline in physical performance in both genders, and baseline strength and performance in men, contributed independently to fracture risk. Sit-to-stand and GS were the tests most consistently associated with fractures. Further studies are required to determine whether muscle strength and/or performance improve the predictive accuracy of fracture prediction models.
Effects of vitamin D supplementation on 25(OH)D levels and blood pressure in the elderly: a systematic review and meta-analysis
Authors: Farapti Farapti , Fadilla Chusnul , Yogiswara Niwanda , Adriani Merryana 
Published: July 2020

Background: Hypertension and vitamin D deficiency are prevalent among the elderly. This study evaluated the effects of vitamin D supplementation on changes in serum 25-hydroxyvitamin D (25(OH)D) levels and blood pressure (BP) in the elderly (age > 60 years). Methods: Randomized controlled trials from electronic databases on the elderly taking oral vitamin D, until the end of March 2019, were selected. Two reviewers independently screened the literature on the basis of specific inclusion criteria. The primary outcomes were serum 25(OH)D level, systolic BP (SBP), and diastolic BP (DBP) changes. Results: Our analysis revealed significant differences in serum 25(OH)D level changes between the vitamin D and control groups (mean difference [MD] = 13.84; 95% confidence interval [CI] = 10.21–17.47; P < 0.000). There were no significant differences in SBP and DBP changes between the vitamin D and control groups. Subgroup analysis revealed significant differences in SBP changes between the hypertensive and vitamin D-deficient subgroups (MD = –4.01; 95% CI = –7.45 to –0.57; P = 0.02 and MD = –1.91; 95% CI = –3.48 to –0.34; P = 0.02, respectively), and DBP changes only in the hypertensive subgroup (MD = –2.22; 95% CI = –4.1 to –0.34; P = 0.02). Conclusions: Vitamin D supplementation significantly increases 25(OH)D levels and seems beneficial in lowering BP, specifically in the elderly with elevated BP and vitamin D deficiency.
Case Report: Cryptococcal meningitis in Hodgkin’s Lymphoma patient receiving brentuximab-vedotin therapy
Authors: Cunha Pereira Tatiana , Rb-Silva Rita , Félix Soares Rita , Domingues Nelson , Mariz José 
Published: July 2020

Cryptococcus neoformans infections occur mostly in immunodeficient individuals, being the most common opportunistic fungi central nervous system (CNS) infection in HIV seropositive patients. Moreover, other conditions affecting host immunity, such as hematologic malignancies, organ transplantation and immunosuppressive drugs are implicated as risk factors. The authors present a case of a 48-year-old male with Hodgkin Lymphoma for 26 years and submitted to several lines of treatment, diagnosed with cryptococcal meningitis while on therapy with brentuximab. The patient presented with positive cerebral spinal fluid (CSF) cryptococcal antigen plus positive blood cultures. He was put under induction antifungal treatment with liposomal amphotericin B and flucytosine, as well as corticotherapy with dexamethasone with headache improvement and a favorable clinical evolution. There are no reported cases of cryptococcal meningoencephalitis under CD30-directed monoclonal antibody. Furthermore, this case illustrates the risk of Cryptococcus neoformans infection in immunocompromising conditions other than HIV, underlining the need of considering this differential diagnosis when physicians face an opportunist neuroinfection.
A questão indígena no Serviço Social: um debate necessário na profissão
Authors: Do Amaral Wagner Roberto , Bilar Jenifer Araujo Barroso 
Published: July 2020

Este artigo intenciona refletir sobre os desafios em torno da (in)visibilidade da questão indígena no âmbito da produção acadêmica do Serviço Social e nos documentos publicizados por entidades representativas da profissão no Brasil. Agrega reflexões sobre a importância da questão indígena associada à questão étnico-racial, temáticas emergentes e progressivamente pautadas pela categoria profissional dos assistentes sociais brasileiros, enquanto componentes estruturantes da questão social no Brasil. O presente trabalho é resultado parcial de pesquisa realizada pelos autores por meio da análise de documentos produzidos por entidades representativas da categoria profissional e de artigos publicados em periódicos e anais de eventos acadêmicos na área de Serviço Social. Apesar dos avanços identificados pela recente inserção da questão indígena no âmbito da categoria profissional, constatou-se o reduzido numero de publicações acerca da questão indígena, sendo premente ampliar as reflexões acerca desta temática pela área do Serviço Social. Palavras-chave: povos indígenas; assistentes sociais indígenas; educação superior indígena; ações afirmativas.
Orthodontics at Times of National Emergency: Past and Current Crises Part 1: Past Crises and Lessons Learnt
Authors: Lee Tara V N , Fowler Peter V , Williams Julie C , Ellis Pamela , Atack Nikki E , Ireland Anthony J 
Published: July 2020

This paper explores past natural disasters such as Hurricane Katrina (USA), the Great East Japan and Christchurch (New Zealand) Earthquakes as well as the HIV and SARS pandemics and the impact they had on providing orthodontic services at the time of the crisis. It also addresses the lessons learnt during the process of recovery and the long-term changes made as a result to the provision of care. CPD/Clinical Relevance: To provide a review of how orthodontics as a specialty survived past crises and to use the lessons learnt to navigate the current COVID-19 pandemic.
The South Wales Peer Review Group: A Case Study in Collaboration Part 1
Authors: Mhani Nizar , Fowler Peter , Lewis Benjamin , Chandler Carlen , Ulhaq Aman , Smith Christine , Williams Julie , Abela Stefan , Vithlani Upen 
Published: July 2020

In this two-part article a novel case study is presented of how peer group collaboration, facilitated through digital technology, can be used to aid and facilitate the development of strategies for overcoming work-based challenges. Part 1 illustrates the importance of peer review in dentistry, introduces the inception of the South Wales Peer Review Group and explores the process of assembling the team of collaborators. Part 2 explains how the various considerations were assessed, how the collaborative ideas evolved and what outcomes were agreed. CPD/Clinical Relevance: During the COVID-19 pandemic, new strategies and protocols need to be developed to adhere to emerging and changing guidelines. The process of peer group collaboration is important for shaping the new service beyond the pandemic.
Condições de higiene e ocorrência de episódios diarreicos em crianças menores de 5 anos residentes na Guatemala
Authors: Lourenço Ana Cláudia Vieira , Nogueira Helena 
Published: July 2020

Este trabalho teve por objetivo avaliar o contributo das condições de higiene do agregado familiar e da salubridade da área de residência, avaliadas por índices compósitos especificamente desenvolvidos para este estudo, na ocorrência de quadros diarreicos em crianças residentes na Guatemala. Realizou-se um estudo ecológico com dados do Ministério da Saúde Pública e Assistência Social e Instituto Nacional de Estatistica. A relação entre a incidência de doença diarreica e os índices criados foi analisada através de coeficientes de correlação de Pearson e de regressões lineares. Em 2018, a incidência desta doença em menores de 5 anos era de 255.70 casos por 1000 crianças, observando-se um máximo de 382.61 casos, no departamento de San Marcos, e um mínimo de 95.23 casos, no departamento de Guatemala. Os resultados revelam a existência de associações significativas entre a incidência de doença diarreica e os índices de salubridade do ambiente da área de residência, salubridade do ambiente domiciliar e higiene dos alimentos consumidos pelas famílias em contexto domiciliar. Os índices de potabilidade da água usada para beber em contexto domiciliar e de higiene pessoal não se mostraram associados à doença. Considerando-se individualmente cada uma das variáveis que compõem estes dois índices, apenas a percentagem de agregados familiares que usa instalações sanitárias compartilhadas revelou associação com a ocorrência de diarreia. Conclui-se que para reduzir o fardo da doença diarreica é necessário implementar programas de educação para a saúde focados na higiene da habitação e espaço envolvente e na higiene alimentar, e de apoio ao saneamento básico.
Endoscopic Ultrasound-Guided Coil Embolization With Absorbable Gelatin Sponge Appears Superior to Traditional Cyanoacrylate Injection for the Treatment of Gastric Varices
Authors: Bazarbashi Ahmad Najdat , Wang Thomas J. , Jirapinyo Pichamol , Thompson Christopher C. , Ryou Marvin 
Published: July 2020

INTRODUCTION:
Gastric variceal (GV) bleeding is a feared complication of cirrhosis. Traditional endoscopic treatment with cyanoacrylate (CYA) injection can be challenging. Alternatively, endoscopic ultrasound (EUS)-guided delivery of hemostatic coils has shown high therapeutic success without the complications profile of CYA alone. Our aim was to compare the clinical outcomes of EUS-guided coil embolization with endoscopic CYA injection for the treatment of GV.

METHODS:
We performed a matched cohort study using a prospective registry involving 2 tertiary centers. A total of 10 patients undergoing EUS-based coil therapy were matched in 1:3 fashion to 30 patients who underwent CYA injection. The matching criteria included type of GV, Charlson comorbidity index, and bleeding severity. Primary outcomes were technical success and complications. Secondary outcomes were rebleeding rates, reinterventions rates, total transfusion requirements, and time-to-event analysis (rebleeding, reintervention, and transfusion).

RESULTS:
Technical success was 100% for EUS coil therapy vs 96.7% for CYA injection (P = 1.0). Complication rates were 10% in the EUS coil group vs 20% in the CYA group; P = 0.65. At 9 months, no EUS coil patient had rebled compared with 38% of the CYA group. No EUS coil patient required blood transfusion for GV rebleed, whereas over 50% of CYA patients did. Ten percent of EUS coil patients required reintervention compared with 60% of CYA patients. The EUS coil group had superior time to reintervention, GV rebleed, and transfusions (all P < 0.05).

DISCUSSION:
Compared with CYA, EUS-guided coil injection appears superior for the treatment of GV and should be considered initial endoscopic treatment of choice in centers with interventional EUS expertise.
Branding of Tourist Destinations
Authors: SHUTAIEVA Elena , POBIRCHENKO Viktoriya , KARLOVA Anna , POLYUKHOVICH Elena 
Published: July 2020

The objective necessity of an integrated approach to destination branding as a process of creating and managing a brand is substantiated. It is shown that the need to develop a strong and successful brand that enhances the image of a tourist destination is associated with fundamental changes in the nature of consumer behavior, due to the fact that for a potential tourist, choosing a vacation destination today is not only an indicator of lifestyle but also a certain status value.
A cognitive analysis of the definitions of the concept of ''tourist destination brand" allowed formulating the authors' definition. According to the authors, a tourist destination brand is a combination of unique qualities, persistent universal values, reflecting the authenticity, unique and original consumer characteristics of this territory and community, which are widely known, gaining public recognition and enjoying stable tourist demand, contributing to the formation of preferences of this territory over others in a situation of choice.
As a research method, modeling was used. Theoretically, it became possible to clarify the essence of the concept of "tourist destination brand" and systematically comprehend the technology of tourist branding by building the authors' model of the brand of tourist destinations.
The authors of the article present the brand as the most important way to implement the competitive advantages of the territory, an instrument of competitiveness, differentiation, and uniqueness. Brands of tourist destinations are designed to emphasize the high quality of services not only in tourism and hospitality, restaurant business, but also in the use of public spaces.
Europejskie dylematy na XXI wiek: między chaosem a ładem międzynarodowym
Authors: Łoś-Nowak Teresa 
Published: July 2020

Autorka tekstu koncentruje, zwraca uwagę Czytelnika na problemie fundamentalnym dla kondycji Europy i stanu bezpieczeństwa świata XXI wieku, w którym mechanizmy – do niedawna stabilizujące relacje międzynarodowe na różnych poziomach systemu międzynarodowego – zostały rozregulowane. Swoista „apolarność” systemu międzynarodowego z jakim jesteśmy konfrontowani niepokoi, rodzi pytania i dylematy co do przyszłości, kierunków zmian i mechanizmów potrzebnych do „poradzenia” sobie z rzeczywistością radykalnie różną od tej w jakiej przynajmniej od półwiecza – z lepszym lub gorszym bilansem strat i zysków – zwykliśmy funkcjonować.
Wysoki stopień niepewności co do kierunków zmian, zasad jakie w tej niepewnej i niedookreślonej rzeczywistości zdominują myślenie o bezpieczeństwie i stabilizacji, o ładzie międzynarodowym wymusza pytania o kształt ładu światowego, jego możliwe projekcje oraz dylematy z jakimi trzeba się zmierzyć, aby jego ostateczny kształt stanowił silne „oparcie” dla bezpieczeństwa europejskiego. Na dzisiaj takiego projektu nie ma, podobnie jak uderzający jest brak wizji ładu, który odzwierciedlałby „adekwatne” oczekiwania, marzenia i racje Europy oraz innych regionów świata, ich mieszkańców, elit politycznych.
Przyjmuję hipotetycznie, iż „ład”/„porządek” europejski w jakim tkwi kontynent jawi się bardziej jako oksymoron, w rodzaju „nieuporządkowanego” porządku europejskiego, „chaotycznego ładu” lub – co wydaje się brzmieć nieco optymistyczniej – „stan” przed uporządkowaniem elementów świata. Jest to jednak wciąż nośnik rozwiązań bardziej zorientowanych do wnętrza kontynentu i jego „wątpliwej” spójności aniżeli do systemu międzynarodowego. Co więcej proponowane rozwiązania zdają się trwać „…w zawieszeniu między przeszłością, którą pragnie przezwyciężyć, a przyszłością której jeszcze nie zdefiniowała” (Kissinger, 2016, s. 95).
Przekroczenie tego progu jest niezbędne. Wymaga jednak, aby Europejczycy odpowiedzieli sobie na ponadczasowe pytanie: „ile jedności jest potrzebne i jak dużą różnorodność kulturowo-cywilizacyjną jest w stanie zaakceptować (tolerować) społeczność międzynarodowa (i rządy), aby porozumienie zapewniające pokój na kolejne stulecia przestało być efemerydą” (Kissinger, 2016, s. 95).
Elementem ważnym w zaprezentowanej narracji jest próba uporządkowania istoty i sensu pojęciowego takich konstrukcji jak „ład”, „porządek”, „chaos”, semiotycznie nieostrych a przez to wieloznacznych. To istotny zabieg analityczny. Czytelne i kluczowe dla wywodu pojęcia konkretyzują przedmiot badań, treść badanych zjawisk i procesów oraz ich funkcje, a przez to umożliwiają budowanie rozwiązań, które łączą różne racje, interesy, oczekiwania.
Crystal structure of 3-(2-ethoxy-2-oxoethyl)-1-vinyl-1H-imidazol-3-ium hexafluoridophosphate(V), C9H13F6N2O2P
Authors: Xiong Wan-Ming , Huang Ting , Liao Sheng , Chen Jing , Nie Xu-Liang 
Published: July 2020

Abstract
[C9H13F6N2O2P], monoclinic, P21/c (no. 14), a = 6.5994(13) Å, b = 10.754(2) Å, c = 19.754(4) Å, β = 96.267(2)°, V = 1393.6(5) Å3, Z = 4, R
gt(F) = 0.0674, wR
ref(F
2) = 0.2124, T = 296(2) K.
Enzyme-mediated synthesis and crystal structure of (2R,4S)-hydroxyketamine, C13H16ClNO2
Authors: Reiss Guido J. , Urlacher Vlada B. , Luelf U. Joost 
Published: July 2020

Abstract
C13H16ClNO2, monoclinic, P21 (no. 4), a = 7.4945(7) Å, b = 7.2336(6) Å, c = 11.5401(10) Å, β = 92.555(2)°, V = 624.99(10) Å3, Z = 2, R
gt(F) = 0.0415, wR
ref(F
2) = 0.0947, T = 291 K.
Synthesis and crystal structure of 1-{4-[(2-bromo-6-hydroxy-benzylidene)amino]phenyl}ethanone, C15H12BrNO2
Authors: Ma Bo-Yang , Fu Tao , Jin Yi , Wei Ping , Zhao Ji-Xing , Zhao Li 
Published: July 2020

Abstract
C15H12BrNO2, monoclinic, P21/c (no. 14), a = 8.0970(3) Å, b = 12.7315(4) Å, c = 12.8542(4) Å, β = 93.785(1)°, Z = 4, V = 1322.21(8) Å3, R
gt(F) = 0.0210, wR
ref(F
2) = 0.0570, T = 173(2) K.
Crystal structure of cyclo[diaqua-bis(μ2-3′,5-dicarboxy-[1,1′-biphenyl]-3,4′-dicarboxylato-κ4
O,O′:O′′,O′′′)-bis(4,4′-bis(pyrid-4-yl)biphenyl-K1
N)dicadmium(II)], C76H52Cd2N4O18
Authors: Li Peng-Jiang , Chen Shi-Jun , Yu Zhi-Bin , Li Shi-Hui 
Published: July 2020

Abstract
C76H52Cd2N4O18, triclinic, P1̄ (no. 2), a = 8.5834(4) Å, b = 10.7034(5) Å, c = 17.6105(8) Å, α = 99.328(4)°, β = 100.580(4)°, γ = 95.281(4)°, V = 1556.94(13) Å3, Z = 1, R
gt(F) = 0.0477, wR
ref(F
2) = 0.1183, T = 293(2) K.
Crystal structure of 4-(4′-(pyridin-4-yl)-[1,1′-biphenyl]-4-yl)pyridin-1-ium 2-carboxy-4-(3,5-dicarboxyphenoxy)benzoate hydrate, C38H28N2O10
Authors: Hu Xu-Ze , Zhao Yan 
Published: July 2020

Abstract
C38H28N2O10, triclinic, P1̄ (no. 2), a = 11.3207(6) Å, b = 11.9296(6) Å, c = 13.6079(8) Å, α = 115.195(5)°, β = 103.259(5)°, γ = 97.356(4)°, V = 1564.58(15) Å3, Z = 2, R
gt(F) = 0.0537, wR
ref(F
2) = 0.1286, T = 293(2) K.
The crystal structure of N-((1E,2E)-1,3-bis(4-fluorophenyl)but-2-en-1-ylidene)-4-methylbenzenesulfonamide, C23H19F2NO2S
Authors: Lang Tianqiong , Ye Jianghai , Zou Taishuang , Tian Xiaolong , Zhao Nengwu 
Published: July 2020

Abstract
C23H19F2NO2S, orthorhombic, Pna21 (no. 33), a = 13.8754(8) Å, b = 7.7354(5) Å, c = 18.4616(11) Å, V = 1981.5(2) Å3, Z = 4, R
gt(F) = 0.0449, wR
ref(F
2) = 0.1066, T = 300(2) K.
Crystal structure of monocarbonyl[2-((cyclopentylmethylene)amino)-5-methylphenolato-κ2N,O] (tricyclohexylphosphine)rhodium(I), C32H48NO2PRh
Authors: Mokolokolo Pennie P. , Alexander Orbett T. , Schutte-Smith Marietjie , Brink Alice , Roodt Andreas 
Published: July 2020

Abstract
C32H48NO2PRh, orthorhombic, P212121 (no. 19), a = 26.784(10) Å, b = 8.837(3) Å, c = 12.759(4) Å, V = 3020.0(18) Å3, Z = 4, R
gt(F) = 0.0400, wR
ref(F
2) = 0.0920, T = 100(2) K.