bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust DNA‐Bridged Memristor for Textile Chips
Authors: Xu Xiaojie , Zhou Xufeng , Wang Tianyu , Shi Xiang , Liu Ya , Zuo Yong , Xu Limin , Wang Mengying , Hu Xiaofeng , Yang Xinju , Chen Jiaxin , Yang Xiubo , Chen Lin , Chen Peining , Peng Huisheng 
Published: April 2020

AbstractElectronic textiles may revolutionize many fields, such as communication, health care and artificial intelligence. To date, unfortunately, computing with them is not yet possible. Memristors are compatible with the interwoven structure and manufacturing process in textiles because of its two‐terminal crossbar configuration. However, it remains a challenge to realize textile memristors owing to the difficulties in designing advanced memristive materials and achieving high‐quality active layers on fiber electrodes. Herein we report a robust textile memristor based on an electrophoretic‐deposited active layer of deoxyribonucleic acid (DNA) on fiber electrodes. The unique architecture and orientation of DNA molecules with the incorporation of Ag nanoparticles offer the best‐in‐class performances, e.g., both ultra‐low operation voltage of 0.3 V and power consumption of 100 pW and high switching speed of 20 ns. Fundamental logic calculations such as implication and NAND are demonstrated as functions of textile chips, and it has been thus integrated with power‐supplying and light emitting modules to demonstrate an all‐fabric information processing system.
Luminescence Amplification at BiVO4 Photoanodes by Photoinduced Electrochemiluminescence
Authors: Yu Jing , Saada Hiba , Abdallah Rawa , Loget Gabriel , Sojic Neso 
Published: April 2020

AbstractPhotoinduced electrochemiluminescence (PECL) combines semiconductor (SC) photoelectrochemistry with electrochemiluminescence (ECL). In PECL, the incident light is converted into a different wavelength by an electrochemical reaction at a SC photoelectrode and allows triggering of ECL at low potentials. This concept has been employed to design up‐conversion systems. However, PECL strongly suffers from the photoelectrochemical instability of these low band gap SCs. Reported here for the first time is an original light‐conversion strategy based on PECL of a luminol derivative (L‐012) at BiVO4 photoanodes in water. Incident light photoexcites simultaneously the L‐012 fluorescence and the photoanode. However, the resulting signal is surpassed by the PECL emission. PECL can be induced at a potential as low as −0.4 V for several hours and can be employed to finely tune L‐012 luminescence. This finding is promising for the design of new analytical strategies and light‐addressable systems.
Relocating to a New OR Suite: Practical Observations
Authors: Weiss Yoram G. , Weissman Charles 
Published: April 2020

ABSTRACTOperating room renovation projects usually involve updated technology and processes that can create challenges for administrative leaders (eg, maintaining a surgery schedule during a move) and require staff member adjustments. The perioperative team of a large tertiary care and trauma center relocated from a 35‐year‐old suite to a new suite, which required years of planning, months of training, and weeks of organizing. This article discusses the processes and observations that helped ensure a smooth transition to the new space. Early planning allowed time for leaders to make equipment decisions, develop and test new processes, and train staff members. The actual move required detailed planning, thorough execution, patience, and flexibility to ensure a safe transition. Perioperative leaders balanced operational needs with relocation plans to maintain patient and staff member safety. Open, multidisciplinary communication combined with staff member participation and buy‐in contributed to an efficient, safe move at this facility.
The Effect of Brush Motion and Rinsing When Manually Cleaning Cannulated Medical Devices
Authors: Bronzatti Jeane Aparecida Gonzalez , Laranjeira Paulo Roberto , Bruna Camila Quartim de Moraes , Graziano Kazuko Uchikawa 
Published: April 2020

ABSTRACTCleaning cannulated medical devices can be challenging for perioperative and sterile processing department personnel. We performed a laboratory experimental study to evaluate differences in cleaning effectiveness using either a back‐and‐forth or helical spinning brushing motion and the effect of rinsing the bristles at each reintroduction of the brush in the lumen. We also tested the lumen cleanliness after high‐pressure water cleansing without brushing. We inspected the devices to determine whether visible soil remained, and we measured the amount of residual organic matter using adenosine triphosphate testing to determine cleaning method effectiveness. The results showed that rinsing the brush during cleaning decreased the amount of organic material that remained in the lumen. A helical spinning motion with brush rinsing at each reintroduction of the brush may be more effective than back‐and‐forth brushing with rinsing, but additional testing with a larger sample size is required to determine whether this result is replicable.
From Education to Practice: Incorporating Quality Improvement Projects Into a Baccalaureate Nursing Curriculum
Authors: Kirby Kristen F. , Good Becky 
Published: April 2020

ABSTRACTThe accelerated pace of change in health care and the call for a radical transformation in prelicensure nursing education will require changes in baccalaureate nursing programs to ensure nurses are adequately prepared for practice. At one Midwestern university, academic nurse educators developed an innovative multilevel interprofessional and intradisciplinary education opportunity using a Lean Healthcare quality improvement (QI) process to improve systems, strengthen academic‐practice partnerships, and bridge the education‐to‐practice gap. During one 16‐week semester, one group of sophomore and junior clinical nursing students worked collaboratively with personnel at a local health care organization on a QI project on sequential compression devices. The students identified practice barriers related to sequential compression device compliance when medication prophylaxis was contraindicated. Using a Lean QI framework, the students developed and implemented a comprehensive, evidence‐based venous thromboembolism prophylaxis policy, including tools and strategies for educating employees and patients.
Clinical Issues—May 2020
Authors: Kyle Erin 
Published: April 2020

THIS MONTH
Using Failure Modes and Effects Analysis to improve special‐order implant procurement
Key words: Failure Modes and Effects Analysis (FMEA), implant procurement, special‐order implant, risk profile number (RPN), interdisciplinary teamwork.
Heat stress among perioperative personnel
Key words: heat stress, environmental conditions, task performance, surgical tasks, OR temperature.
Venous thromboembolism prevention for bariatric surgery patients
Key words: venous thromboembolism (VTE), prophylactic measures, bariatric surgery, risk factors, prevention protocol.
Disinfecting case carts using ultraviolet light systems
Key words: environmental cleaning, decontamination, case cart, ultraviolet (UV) light system, pulsed xenon.
GSH‐responsive polyglutamic acid nanocarriers for dual targeted cancer therapy
Authors: Li He‐Yi , Jing Fang‐kun , Hao Jun‐Feng 
Published: April 2020

AbstractIn order to reduce the toxic side effects of chemotherapeutic drugs and improve the targeting and efficiency of cancer treatment, the development of drug delivery system has received great attention. In this study, second generation polyglutamic acid dendrimers (G2) are used as basic materials to produce porous nanoparticles through cross link by crosslinkers containing disulfide bonds. The crosslinked products (G2)n have negative electricity and abundant voids, which enable them to adsorb the electronegative anticancer drug DOX. At the same time, in order to transport DOX to the tumor site, we modified FA on DOX and encapsulated it in magnetic mesoporous silica (FA‐DOX‐MSNs). Therefore, the final nanoparticles (FA‐DOX‐MSNs/(G2)n) not only have dual targeting ability to transport DOX to the tumor site, but also have reductive responsiveness that can release drugs responsively in the tumor cells. In addition, it has good biocompatibility and endocytosis ability.
Noncompetitive tight‐binding inhibition ofAnticarsia gemmatalistrypsins byAdenanthera pavoninaprotease inhibitor affects larvae survival
Authors: Meriño‐Cabrera Yaremis , de Oliveira Mendes Tiago A. , Castro José G. S. , Barbosa Samuel L. , Macedo Maria L. R. , de Almeida Oliveira Maria G. 
Published: April 2020

AbstractThe economic loss in soybean crops caused by the Lepidoptera insects has encouraged the search for new strategies to control this pest, which are currently based on synthetic insecticides. This paper evaluated the ability of ApTI (Adenanthera pavoninatrypsin inhibitor) to inhibit trypsin‐like proteins fromAnticarsia gemmatalisby docking, molecular dynamics, and enzymatic and survival assay. The docking and molecular dynamic simulation between trypsin and ApTI were performed using the program CLUSPRO and NAMD, respectively. The inhibitory constantKiand the inhibition type were determined through chromogenic assays. The survival assay of neonatal larvae under treatment with artificial diet supplemented with ApTI was also performed. The ApTI binding site was predicted to block substrate access to trypsin due to four interactions with the enzyme, producing a complex with a surface area of 1,183.7 Å2. The kinetic analysis revealed a noncompetitive tight‐binding mechanism. The survival curves obtained using Kaplan–Meier estimators indicated that the highest larvae mortality was 60%, using 1.2 mg of ApTI per 100 ml of artificial diet. The in vitro, in vivo, and in silico studies demonstrated that ApTI is a strong noncompetitive inhibitor of trypsin with biotechnological potential for the control ofA. gemmatalisinsect.
Angiotensin‐converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease
Authors: Saleh Nagwan Y. , Salem Sherif S. , Abo‐El fotoh Wafaa MM. , Soliman Shaimaa E. , Abo‐Haded Hany M. 
Published: April 2020

AbstractBackgroundCongenital heart diseases (CHDs) are the leading cause of infant deaths worldwide. The relationship between angiotensin‐converting enzyme (ACE) gene polymorphism and CHDs is not clear. The aim of this work is to assess the presence of an association between ACE I/D polymorphism and CHD in Egyptian population.Subjects and methodsSeventy CHD cases and 70 controls were incorporated in this study. DNA was isolated from their peripheral blood, and then ACE I/D gene polymorphism was tested by polymerase chain reaction (PCR).ResultsThere was no significant difference among the frequencies of the DD, II, and DI genotypes in patients and controls (26 [37.1%], 37 [53.3%], and 4 [5.7%], 5 [6.7%]), 40 (57.2%), 28 (40%), respectively (p value = 1 and OR [95% CI] = 1.1). There was no significant difference between D allele (DD + DI) and II genotype distribution among patients and controls (p value = 1 and OR [95% CI] = 1.2 [0.3–2.9]). Moreover, there was no difference between I allele (II + DI) and DD frequency (p value = 0.2 and OR [95% CI] = 0.6 [0.3–1.2]).ConclusionsACE I/D gene polymorphism might not be a risk factor of CHD in Egyptian children. Additional widespread studies are needed to affirm these data.
Benzoic acid production via cascade biotransformation and coupled fermentation‐biotransformation
Authors: Zhou Yi , Sekar Balaji Sundara , Wu Shuke , Li Zhi 
Published: April 2020

AbstractAs an important bulk chemical, benzoic acid is currently manufactured from nonrenewable feedstocks under harsh conditions. Although there are natural pathways for biosynthesis of benzoic acid, they are often inefficient and subjected to complex regulation. Here we develop a nonnatural enzyme cascade to efficiently produce benzoic acid from styrene or biogenic L‐phenylalanine under mild conditions. By using a modular approach, two whole‐cell catalysts Escherichia coli LZ305 and LZ325 are engineered for coexpressing seven and nine enzymes for production of 133–146 mM benzoic acid (16.2–17.8 g/Laq) with 88–97% conversion via seven‐ and nine‐step cascade biotransformation of styrene and L‐phenylalanine, respectively. The seven‐step cascade represents a formal high‐yielding biocatalytic oxidative cleavage of styrene, and the nine‐step cascade showcases the high efficiency of extended nonnatural enzyme cascades. Moreover, to achieve benzoic acid production directly from low‐cost renewable glycerol, a novel coupled fermentation‐biotransformation process was developed by integration of fermentative production of L‐phenylalanine with in situ biotransformation to give 63–70 mM benzoic acid (7.6–8.6 g/Laq), which is around 20 times higher than the reported value via a natural pathway. The coupled fermentation‐biotransformation process could be generally applicable to microbial production of growth‐inhibitory or toxic chemicals in high concentrations.
Static and dynamic functional connectivity analysis of cerebrovascular reactivity: An fMRI study
Authors: Lewis Noah , Lu Hanzhang , Liu Peiying , Hou Xirui , Damaraju Eswar , Iraji Armin , Calhoun Vince 
Published: April 2020

AbstractBackgroundCerebrovascular reactivity (CVR) is an important aspect of brain function, and as such it is important to understand relationship between CVR and functional connectivity.MethodsThis research studied the role of CVR, or the brain's ability to react to vasoactive stimuli on brain functional connectivity by scanning subjects with blood‐oxygenation‐level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) while they periodically inhale room air and a CO 2‐enriched gas mixture. We developed a new metric to measure the effect of CVR on each intrinsic connectivity network (ICN), which contrasts to voxel‐wise CVR. We also studied the changes in whole‐brain connectivity patterns using both static functional network connectivity (sFNC) and dynamic FNC (dFNC).ResultsWe found that network connectivity is generally weaker during vascular dilation, which is supported by previous research. The dFNC analysis revealed that participants did not return to the pre‐CO 2 inhalation state, suggesting that one‐minute periods of room‐air inhalation is not enough for the CO 2 effect to fully dissipate.ConclusionsCerebrovascular reactivity is one tool that the cerebrovascular system uses to ensure the constant, finely‐tuned flow of oxygen to function properly. Understanding the relationship between CVR and brain dynamism can provide unique information about cerebrovascular diseases and general brain function. We observed that CVR has a wide, but consistent relationship to connectivity patterns between functional networks.
Counterion Enhanced Organocatalysis: A Novel Approach for the Asymmetric Transfer Hydrogenation of Enones
Authors: Scharinger Fabian , Márk Pálvölgyi Ádám , Zeindlhofer Veronika , Schnürch Michael , Schröder Christian , Bica‐Schröder Katharina 
Published: April 2020

AbstractWe present a novel strategy for organocatalytic transfer hydrogenations relying on an ion‐paired catalyst of natural l‐amino acids as main source of chirality in combination with racemic, atropisomeric phosphoric acids as counteranion. The combination of a chiral cation with a structurally flexible anion resulted in a novel chiral framework for asymmetric transfer hydrogenations with enhanced selectivity through synergistic effects. The optimized catalytic system, in combination with a Hantzsch ester as hydrogen source for biomimetic transfer hydrogenation, enabled high enantioselectivity and excellent yields for a series of α,β‐unsaturated cyclohexenones under mild conditions. Moreover, owing to the use of readily available and chiral pool‐derived building blocks, it could be prepared in a straightforward and significantly cheaper way compared to the current state of the art.
Ni2P‐Modified Ta3N5 and TaON for Photocatalytic Nitrate Reduction
Authors: Wei Lin , Adamson Marquix A. S. , Vela Javier 
Published: April 2020

AbstractSelf‐sustaining photocatalytic NO3− reduction systems could become ideal NO3− removal methods. Developing an efficient, highly active photocatalyst is the key to the photocatalytic reduction of NO3−. In this work, we present the synthesis of Ni2P‐modified Ta3N5 (Ni2P/Ta3N5), TaON (Ni2P/TaON), and TiO2 (Ni2P/TiO2). Starting with a 2 mM (28 g/mL NO3−−N) aqueous solution of NO3−, as made Ni2P/Ta3N5 and Ni2P/TaON display as high as 79% and 61% NO3− conversion under 419 nm light within 12 h, which correspond to reaction rates per gram of 196 μmol g−1 h−1 and 153 μmol g−1 h−1, respectively, and apparent quantum yields of 3–4%. Compared to 24% NO3− conversion in Ni2P/TiO2, Ni2P/Ta3N5 and Ni2P/TaON exhibit higher activities due to the visible light active semiconductor (SC) substrates Ta3N5 and TaON. We also discuss two possible electron migration pathways in Ni2P/semiconductor heterostructures. Our experimental results suggest one dominant electron migration pathway in these materials, namely: Photo‐generated electrons migrate from the semiconductor to co‐catalyst Ni2P, and upshift its Fermi level. The higher Fermi level provides greater driving force and allows NO3− reduction to occur on the Ni2P surface.
A Single Molecular Stoichiometric P‐Source for Phase‐Selective Synthesis of Crystalline and Amorphous Iron Phosphide Nanocatalysts
Authors: D'Accriscio Florian , Schrader Erik , Sassoye Capucine , Selmane Mohamed , André Rémi F. , Lamaison Sarah , Wakerley David , Fontecave Marc , Mougel Victor , Le Corre Grégoire , Grützmacher Hansjörg , Sanchez Clément , Carenco Sophie 
Published: April 2020

AbstractThe formation of iron phosphide nanoparticles (FexP NPs) is a well‐studied process. It usually uses air‐sensitive phosphorus precursors such as n‐trioctylphosphine or white phosphorus. In this study, we report the synthesis and characterization of a remarkably stable tetrakis(acyl)cyclotetraphosphane, P4(MesCO)4. We demonstrate that this compound can be used as a stoichiometric source of P(0) species in order to synthesize FeP and Fe2P nanoparticles at only 250 °C. This tunable process provides a route to monodisperse nanoparticles with different compositions and crystallinities. We combine X‐Ray photoelectron spectroscopy (XPS) and atomic pair distribution function (PDF) in order to study the local order and bonding in the amorphous and crystalline materials. We show that crystalline FeP forms via an intermediate amorphous phase (obtained at a lower temperature) that presents local order similar to that of the crystalline sample. From the results of this work, a better understanding of the mechanism of the formation of amorphous and crystalline FexP NPs is provided which relies on the use of a stoichiometric and single P‐source. We then explore the electrocatalytic properties of FexP nanoparticles for the hydrogen evolution reaction (HER) in acidic and neutral electrolytes. In both electrolytes, amorphous FeP is a more efficient catalyst than crystalline FeP, itself more efficient than crystalline Fe2P. Our study paves the way for a more systematic investigation of amorphous metal phosphide phases in electrocatalysis. It also shows the beneficial properties of PDF on the characterization of such nanomaterials, which is highly challenging.
Task‐allocation in a large‐scaled hierarchical many‐core topology
Authors: Lund Andreas , Brinkschulte Uwe 
Published: April 2020

SummaryAs more and more electronic devices get connected together, whole systems get more complicated in terms of development, maintenance and usage. New principles in design are needed to cope with this complexity. That is why we developed the artificial hormone system (AHS). The AHS enables an autonomous and decentralized task‐allocation among a set of processing elements (PEs). The AHS works good in small‐scaled nonhierarchical scenarios. For larger scaled and hierarchical scenarios, we developed the hierarchical artificial hormone system (HAHS) and presented a first abstract concept of the recursive artificial hormone system (RAHS). Both utilize the AHS in isolated smaller clusters of PEs to achieve the same functionality as the AHS with less communication. Thus, the whole task‐set will be split into smaller and disjoint task‐subsets which then will be distributed to the clusters. The HAHS uses a two‐level hierarchy with a second regulation cycle between all clusters. The RAHS on the other hand is designed to manage a n‐level hierarchy. In this article, we will present the first two implemented versions of the RAHS, their evaluation, and the comparison to the original AHS.
Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene‐Ruthenium Arene Conjugates
Authors: Gelle Donát , Lamač Martin , Mach Karel , Šimková Ludmila , Gyepes Róbert , Sommerová Lucia , Martišová Andrea , Bartošík Martin , Vaculovič Tomáš , Kanický Viktor , Hrstka Roman , Pinkas Jiří 
Published: April 2020

AbstractCoordination of arenophilic Cp*Ru+ (Cp*=η5‐C5Me5) fragment to pendant aromatic ring(s) of either benzylferrocene (1) or dibenzylferrocene (2) gave air‐ and water‐stable dinuclear (4) or trinuclear (6) ferrocene‐ruthenium conjugates. The complexes were characterized by NMR, ESI‐MS, cyclic voltammetry (CV), elemental analysis, and the molecular structure of 4 was established by single crystal X‐ray diffraction. Contrary to the starting ferrocenes 1 and 2, conjugates 4 and 6 showed significant in vitro anticancer activity (up to IC50 0.6±0.2 μM) against various cancer cell lines (A2780, SK‐OV‐3, MDA‐MB‐231). Differential pulse voltammetry (DPV) showed that the intracellular accumulation of 4 was approximately twice that of 6 in all studied cell lines, which corresponds to a higher cytotoxicity of 4.