bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solubility-Permeability Interplay of Hydrotropic Solubilization Using Response Surface Methodology
Authors: Nainwal Nidhi , Jawala Sunil , Singh Ranjit , Saharan Vikas A. 
Published: February 2020

Background::
The solubility/dissolution of a drug in the gastrointestinal (GI) region and the
permeability of a drug through the GI membrane are the two key parameters governing drug absorption.
Poor aqueous solubility is the rate-limiting factor for the absorption of poorly soluble drugs
through the GI region.

Objective:
The purpose of this work is to investigate the influence of two different hydrotropes, namely
sodium benzoate (SB), and nicotinamide (NA), at different levels (10-40%) and in combination on the
solubility and permeability of poorly soluble drug glibenclamide (GLB). The work will find out,
whether the solubility enhancement of glibenclamide using hydrotropes and hydrotropic blends also affects
the GI permeability of glibenclamide.

Methods:
A 32 full factorial design was employed to study the influence of hydrotropic blends of sodium
benzoate and nicotinamide on the solubility and permeability of GLB. The solubility and permeability
of drugs at different levels (10-40%) of hydrotropes (SB, NA) and their blends are determined
using a magnetic stirrer and in vitro Franz diffusion cell, respectively.

Results:
The results of preliminary studies revealed an increase in the solubility and reduction in the
apparent permeability of GLB as a function of increasing levels of both hydrotropes.

Conclusion:
In this work, it was found that an increase in solubility with hydrotropes results in a decrease
in permeability of GLB. The solubility enhancement and the permeability decrease were observed
more in hydrotropic blends in comparison to individual hydrotropes. Therefore, it is concluded
that both factors, solubility and permeability, must be optimized to achieve appreciable gains in
bioavailability.
Gene Expression and Resistance to Glucocorticoid-Induced Apoptosis in Acute Lymphoblastic Leukemia: A Brief Review and Update
Authors: Lambrou George I. , Adamaki Maria , Hatziagapiou Kyriaki , Vlahopoulos Spiros 
Published: February 2020

Background:Resistance to glucocorticoid (GC)-induced apoptosis in Acute Lymphoblastic Leukemia (ALL), is considered one of the major prognostic factors for the disease. Prednisolone is a corticosteroid and one of the most important agents in the treatment of acute lymphoblastic leukemia. The mechanics of GC resistance are largely unknown and intense ongoing research focuses on this topic.Aim:The aim of the present study is to review some aspects of GC resistance in ALL, and in particular of Prednisolone, with emphasis on previous and present knowledge on gene expression and signaling pathways playing a role in the phenomenon.Methods:An electronic literature search was conducted by the authors from 1994 to June 2019. Original articles and systematic reviews selected, and the titles and abstracts of papers screened to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved.Results:Identification of gene targets responsible for glucocorticoid resistance may allow discovery of drugs, which in combination with glucocorticoids may increase the effectiveness of anti-leukemia therapies. The inherent plasticity of clinically evolving cancer justifies approaches to characterize and prevent undesirable activation of early oncogenic pathways.Conclusions:Study of the pattern of intracellular signal pathway activation by anticancer drugs can lead to development of efficient treatment strategies by reducing detrimental secondary effects.
PENGARUH MOTIVASI BELAJAR, PERSEPSI SISWA TENTANG METODE MENGAJAR GURU, DAN PERHATIAN ORANG TUA TERHADAP PRESTASI BELAJAR AKUNTANSI DASAR SISWA KELAS X AKUNTANSI DAN KEUANGAN LEMBAGA SMK NEGERI 1 WONOSARI TAHUN AJARAN 2018/2019
Authors: Intan Utari Nur Fitria , Djazari Moh. 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui Pengaruh Motivasi Belajar, Persepsi Siswa tentang Metode Mengajar Guru, dan Perhatian Orang Tua terhadap Prestasi Belajar Akuntansi Dasar Siswa Kelas X AKL SMK Negeri 1 Wonosari Tahun Ajaran 2018/2019, baik secara sendiri-sendiri, maupun secara bersama-sama. Penelitian ini merupakan penelitian ex-post facto dengan pendekatan kuantitatif. Populasi penelitian sebanyak 127 siswa. Pengumpulan data mengunakan metode angket dan metode dokumentasi. Uji prasyarat analisis menggunakan uji linearitas dan uji multikolinearitas. Uji hipotesis yang digunakan adalah analisis regresi sederhana dan analisis regresi ganda tiga prediktor. Hasil dari penelitian ini adalah: (1) Terdapat pengaruh positif Motivasi Belajar terhadap Prestasi Belajar Akuntansi Dasar dibuktikan dengan rx1y = 0,348, r2x1y = 0,114, dan thitung ttabel (4,012 1,657) .(2) Terdapat pengaruh positif Persepsi Siswa tentang Metode Mengajar Guru terhadap Prestasi Belajar Akuntansi Dasar dibuktikan dengan rx2y = 0,275, r2x2y = 0,076 dan thitung ttabel (3,204 1,657). (3) Terdapat pengaruh positif Perhatian Orang Tua terhadap Prestasi Belajar Akuntansi Dasar dibuktikan dengan rx3y = 0,254, r2x3y = 0,064, dan thitung ttabel (2,301 1,657). (4) Terdapat pengaruh positif Motivasi Belajar, Persepsi Siswa tentang Metode Mengajar Guru, dan Perhatian Orang Tua secara bersama-sama terhadap Prestasi Belajar Akuntansi Dasar, yang dibuktikan dengan Ry(1,2,3) = 0,391, R2y(1,2,3) = 0,153, dan Fhitung Ftabel (7,398 2,678). Sumbangan Efektif (SE) menunjukkan total sebesar 15,30%. Kata kunci: Motivasi Belajar, Persepsi Siswa tentang metode Mengajar Guru, Perhatian Orang Tua, Prestasi Belajar Akuntansi Dasar
Determination of microbial load, total Phenolic and flavonoids contents in polyherbal formulation “yograj guggulu vati”
Authors: Dutt Vimal , Srivastav Shivani , Mittal Swati , Haque Md Rafiul 
Published: February 2020

Yograj guggulu vati (YGV), a polyherbal formulation is recommended for the management of diseases like arthritic, anodyne or analgesic, spasm, muscle relaxant, flatulence, digestive problem, cough, hyperglycaemia, fat burner and obesity. Though Yograj guggulu vati is widely used for the treatment of diseases in Ayurvedic System of Indian Medicine, but till date, it’s Phenolic and flavonoids contents and contamination studies have not been carried. In the present article, we evaluated the total phenolic and flavonoids contents and contamination of YGV. Total phenolic contents were evaluated by Folin Ciocalteu reagent. Aluminum chloride colorimetric method was used for the determination of total flavonoid contents. Contamination study such as microbial load was also performed. Microbial load study revealed that total bacterial counts and total fungal counts were under limits. The total phenolic content and total flavonoid content were 190.16 mg/g and 20.87 mg/ g dry extract respectively. Microbial load studies showed that the formulation has a good quality and purity. Presence of abundance phenolic and flavonoids compound indicated that YGV can be used for different biological activities.
Keywords: Microbial load, Yograj Guggulu Vati, total phenolic contents
Physostigmine: A Plant Alkaloid Isolated from Physostigma venenosum: A Review on Pharmacokinetics, Pharmacological and Toxicological Activities
Authors: Batiha Gaber El-Saber , Alkazmi Luay M. , Nadwa Eman H. , Rashwan Eman K. , Beshbishy Amany Magdy , Shaheen Hazem , Wasef Lamiaa 
Published: February 2020

Medicinal plants have been documented as an important source for discovering new pharmaceutical molecules that have been used to treat serious diseases. Strikingly, previous reports stated that natural products and their derived compounds exhibit lesser side effects and improved efficacy than other synthetic counterparts. Physostigmine, a parasympathomimetic plant alkaloid isolated from the West African perennial shrub Physostigma venenosum, it shows a narrow therapeutic index and a short life span, despite its ability to penetrate the blood-brain barrier (BBB). It is a widely known reversible butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) inhibitor and has been documented to treat various ailments such as Alzheimer’s disease. Pharmacologically, physostigmine was first reported as an antidote for atropine scopolamine and belladonna alkaloids toxicity. Recently, it has been documented as a therapy for treating several ailments including glaucoma, myasthenia gravis and the intoxication caused by tricyclic antidepressant overdoses, anti-histamines, antipsychotics, and benzodiazepines. Physostigmine has been reported to be absorbed from the gastrointestinal tract and showed short half-life, as, after the oral administration of 2 mg of physostigmine salicylate, the peak plasma concentration reached to 30 minutes. This review examines the biological activities, pharmacokinetics, and toxicity of physostigmine extracted from P. venenosum.
Keywords: Physostigma venenosum, Physostigmine, pharmacological activities, acetylcholinesterase and butyrylcholinesterase inhibitor.
Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet
Authors: Uchendu Ikenna Kingsley , Ekeigwe Ifeoma Blessing , Nnedu Ebuka Bitrus 
Published: February 2020

Objective: The aim of this study is to evaluate the antidyslipidaemic and cardioprotective effects of aqueous extract of Curcuma longa (AECL) in rats fed a high cholesterol diet (HCD).
Methods: Twenty (20) rats were randomly grouped into four groups: A-D of five animals per group. Groups A-C received HCD (2000mg/kg, oral) and carbimazole (60mg/kg, oral) daily for eight weeks. Group A served as negative control. Group B (positive control) was treated with atorvastatin (20mg/kg), while group C served as treatment group and received AECL (400mg/kg) daily for eight weeks. Group D served as normal control and received no treatment. After the administration, biochemical markers of Lipid profiles (total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C)) were assayed using standard methods. The hearts of the rats were harvested for histopathological studies.
Results: AECL significantly induced hypolipidaemia and stabilized lipid biochemical markers (p<0.05 or p<0.01); and protected the cardiac muscle fibres from injuries.
Conclusion: Tumeric (Curcuma longa) has antidyslipidaemic and cardioprotective effects.
Keywords: antidyslipidaemia, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemia, Medicinal foods, cardiomyopathy
A Comprehensive Review on Plant derived Natural products for Diabetes and its complication as nephropathyExtraction and Quantitative Estimation of Chrysophanol From Cassia tora Meal Powder by High-Performance Liquid Chromatography
Authors: Gangurde Subodh A , Laddha Kirti S 
Published: February 2020

An isocratic reverse phase HPLC method were described to determined chrysophanol contain in cassia tora meal powder obtained during the split manufacturing process of cassia tora seed husk and germs which are used as a valuable cattle feed and poultry feed as they are quite rich in protein. The method involves methanol: water (90:10) with 0.05% Ortho-Phosphoric acid as solvent system and chromatogram detection was done on 254 nm using photodiode array detector. Chrysophanol were extracted using methanol, 70% methanol, acid hydrolysis and Oxidative hydrolysis by different concentration of the Hydrochloric acid and ferric chloride respectively. An average chrysophanol content was observed in cassia tora meal powder was 0.066 percent. In an efforts to develop an improved method for the determination of content of chrysophanol which is important marker compound in cassia tora meal and also improve method of an extraction methods. The solvents for extraction of chrysophanol from cassia tora were examined in order to increase the chrysophanol contents in cassia tora meal powder. It was found that 70% methanol, 20% HCL (v/v) and 3% FeCl3 (v/v) was capable of increasing the chrysophanol contain up to 0.099 percent.
Keywords: HPLC, Chrysophanol, Extraction, Cassia tora meal powder
Investigation of Drug Distribution Process and Pharmacy Practices on Model Pharmacy in Dhaka City, Bangladesh
Authors: Rahman Md. Mominur , Sherin Shafana , Jubayer Ahasanul Mahabub , Islam Fahadul , Jahan Nusrat , Rahaman Md. Saidur , Sumi Moriam Akter , Akter Khandaker Sanjida , Mukhles , , Rahman Firoza , Hossain Md Farid , Faysal Md. 
Published: February 2020

Objectives: In Bangladesh, Drug distribution process is very important cause of our increasing economic and development. In the recent days Model pharmacy has become an important theme of study for the student in pharmacy. In Bangladesh the introduction of the model pharmacy practice likes other skilled and semi-skilled health professionals will certainly improve primary health care system. The aim of the study was to develop a strategy to improve the overall services of model pharmacy in Bangladesh.
Methodology: A total of 20 model pharmacies were the study subject. The study cover the model pharmacy located in Dhaka city, where each pharmacy was accounted through a questioner on random basis. The form includes their facilities, management system, drug distribution process and counseling system.
Results: Study showed that, out of 20 Pharmacists, 95% of them used Software tools for their drug dispensing system. There was a helpline system for individual, online order within a short time of delivery system, discount system and membership card. The most important significant factors are counseling by “A grade” pharmacists, patient database system, affordable price and quality of medicine.
Conclusions: If we improve those model pharmacies and if the aim is successful, then it will be spread across Bangladesh and model pharmacy will be established gradually with digitalization.
Keyword: Model pharmacy, Bangladesh, Dhaka city, Pharmacist, Drug distribution process
A Study on Appropriateness of Antibacterial Use in Acute Wards of a Teaching Hospital
Authors: Jaiswal Sanjay , Shyam Sharan , Yadav Vikas 
Published: February 2020

Objective: A study to analyse the appropriateness of use of antibacterials in acute wards of a tertiary care hospital. Design: A pharmacoepidemiological research study. Intervention: Non-interventional descriptive study. Main Outcome Measure: The antibacterial prescriptions were analyzed for their adherence to or deviation from the standard national treatment guidelines. Results: There were a total of 207 patients comprising of 35 in acute medical ward, 65 in ICU, 53 in acute surgical ward and 54 in family ward, who were prescribed antibacterials. These consisted of a total of 383 prescription counts for appropriateness of AMA use. One third of the antibacterial prescriptions of inpatients surveyed were for prophylactic use followed by the treatment of respiratory and gastrointestinal diseases. The highest prescription counts were seen with carbapenems followed by nitroimidazoles, cephalosporins, aminoglycosides and penicillins. 99% of the prescriptions were appropriate for the dose used and 49.6% of the prescriptions were inappropriate for duration of use. 74.5% of the surgical prophylaxis prescriptions were used for more than 24 hours. Ceftriaxone and cefotaxime were used instead of the recommended cefazolin, for prophylaxis. High percentage of deviation was observed with prescriptions of cefotaxime and metronidazole for empirical use. No definitive use of antimicrobials for infections was observed in the ICU. Conclusion: A high percentage of appropriateness was observed for dose of antibiotic used. The main targets identified for improvement are duration of antimicrobial use, choice of drug for surgical prophylaxis and the definitive use of antimicrobial agents.
Keywords: adherence to treatment guidelines, antibiotic audit, antimicrobials.
O movimento antivacina no YouTube nos tempos de pós-verdade: Educação em saúde ou desinformação?
Authors: Da Costa Bianca Barros , Viegas Daiane de Jesus , Moreira Thamyris Almeida , Abreu Paula Alvarez 
Published: February 2020

Apesar dos benefícios da vacinação, movimentos antivacinação têm se espalhado pelo mundo. Neste estudo foi feita uma análise dos vídeos sobre o movimento antivacina no YouTube, o seu impacto em visualizações e a aceitação dos usuários. Foram realizadas duas buscas em períodos diferentes e 14 vídeos se mantiveram entre os mais relevantes nas buscas. A maioria dos vídeos foi contra o movimento e nestes havia profissionais de saúde que explicaram os benefícios das vacinas, enquanto os vídeos a favor usaram argumentos sem base científica, fake news e teorias conspiratórias. Apesar de serem a minoria, os vídeos a favor do movimento tiveram milhares de visualizações e houve aumento da razão like/dislike, mostrando que muitos seguidores se identificaram com o conteúdo. Em tempos de pós-verdade é essencial entender como as mídias sociais influenciam nas decisões em saúde.
IDENTIFIKASI KENYAMANAN PEJALAN KAKI DI CITY WALK JALAN SLAMET RIYADI SURAKARTA
Authors: Harsono Kuncoro , Arsandrie Yayi , Setiawan Wisnu 
Published: February 2020

Pedestrian adalah jalur bagi para pejalan kaki ataupun kursi roda bagi kelompok
pengguna berkebutuhan khusus, yang dirancang berdasarkan kebutuhan orang untuk
bergerak aman, nyaman dan tak terhalang, termasuk jalur City Walk di Jalan Slamet
Riyadi Surakarta. Penelitian ini bermaksud mengkaji ulang apakah City Walk di Jalan Slamet Riyadi Surakarta sudah memenuhi standar kenyamanan bagi penggunanya, termasuk penyandang cacat dan lansia, serta standar aksesibilitas pada fasilitas-fasilitasnya. Penelitian ini mencoba mengidentifikasi faktor kenyamanan yang ada di City Walk. Metode penelitian yang digunakan adalah metode deskriptif dengan menge-mukakan fakta-fakta yang ada di lapangan, kemudian dibandingkan dengan standar aksesibilitas. Hasil riset menunjukkan bahwa secara umum jalur City Walk di Jalan Slamet Riyadi Surakarta memiliki fasilitas-fasilitas utama yang sudah memenuhi standar, seperti lebar pedestrian, kondisi tempat duduk dan vegetasi. Hanya terdapat kekurangan pada kondisi kebersihan dan ketersediaan rambu-rambu bagi kelompok pengguna berkebutuhan khusus. Gangguan terbesar yang dirasakan pengguna bersumber dari keberadaan parkir liar dan Pedagang Kaki Lima (PKL).
IDENTIFIKASI KARAKTER BANGUNAN ISLAMI PADA PESMA PUTRI KH. MAS MANSUR UMS
Authors: Shochfah Ikrima Iffah 
Published: February 2020

Pesantren Mahasiswa (Pesma) Putri K.H. Mas Mansur UMS, adalah sebuah asrama mahasiswa yang difungsikan sebagai pesantren mahasiswa.sebagai tempat tinggal bagi mahasiswa internasional dan mahasiswa lokal. Pesantren Mahasiswa ini, didukung oleh program Islami dan sebaiknya diikuti oleh desain ruangan yang Islami pula.Urgensi riset ini untuk mengetahui apakah Pesma Putri K.H. Mas Mansur UMS sudah menerapkan kaidah aturan Islami dalam bangunannya. Tujuan penelitian ini adalah: (a). mengidentifikasi dan menemukan karakter bangunan Islami yang sudah diterapkan pada Pesma K.H. Mas Mansur UMS. b). Menganalisis perwujudan karakter bangunan Islami pada elemen arsitektur bangunan Pesma KH Mas Mansur UMS. Metodepenelitian yang digunakan secara umum adalah metode kualitatif. Analisis menggunakan metode deskriptif komparatif, menggambarkan kondisi faktual dengan mengemukakan fakta-fakta yang ada di lapangan serta membandingkannya antara satu kondisi dengan kondisi lainnya. Hasil Penelitian menunjukkan bahwa KH Mas Mansur mempunyai sebagian besar karakter bangunan Islami, mulai dari zonasi, tata ruang,ornamen seni hias Islami, lay out interior peruangan, orientasi bangunan dan fasad bangunan.
DARI WISATA KREATIF MENUJU SOLO KOTA KREATIF
Authors: Priyatmono Alpha Febela 
Published: February 2020

Solo merupakan kota tradisional Jawa telah lama membentuk tata ruang kotanya secara unik dan spesifik. Solo dengan Kraton sebagai salah satu titik awal tumbuhnya kebudayaan dan ruang kota, berkembang melalui suatu disain kawasan yang tidak muncul secara intuitif tetapi melalui suatu konsep yang direncanakan secara matang. Kraton dengan konsep makro kosmos dan mikro kosmos serta seting kawasan hunian masya-rakatnya dalam hal ini khususnya kampung, mewarnai perkembangan wajah kota Solo dari kota tradisional menjadi kota kreatif. Dalam perkembangannya kraton dan aset heritage lainnya menjadi potensi wisata kreatif kota Solo. Kreatifitas suatu kota sangat ditentukan oleh aktifitas penduduknya, wadah kegiatan kreatif penduduk suatu kotadimungkinkan terjadi di semua elemen pembentuk kawasan kota. Kreatifitas kota dapat diaktualisasikan di area umum antara lain : jalan raya, pedestrian, gang, jembatan, jalur pejalan kaki, jalan kereta api, sungai, taman kota, plaza, kampung halaman, serta area privat antara lain pagar dan bangunan. Dalam perkembangannya, wisata berbasis kreatif mempunyai andil yang cukup besar dalam mengembangkan suatu elemen pembentuk kota menjadi kawasan kreatif. Sejauh mana wisata kreatif yang terjadi di elemen pembentuk kota khususnya kampung dapat mendorong terwujudnya kota kreatif. Berdasarkan studi literatur dan observasi lapangan, aktifitas wisata kreatif yang terkoor- dinir dengan mengangkat potensi kawasan khususnya di bidang ekonomi, fisik lingkungan , tradisi sosial budaya yang berbasis pada potensi lokal, akan menjadi salah satu generator terwujudnya kota kreatif.
KENYAMANAN LIFT BAGI KAUM DIFABLE STUDI KASUS DI R.S KASIH IBU, R.S ISLAM YARSIS DAN R.S MOEWARDI SURAKARTA
Authors: Wijiyanto Wijiyanto , Raidi Samsudin 
Published: February 2020

Transportasi vertikal adalah transportasi yang digunakan untuk mengangkut sesuatu benda dari bawah ke atas atau moda transportasi yang direncanakan untuk memenuhi kebutuhan para penghuni untuk mendukung aktivitas pada gedung bertingkat. Transportasi vertikal terdiri dari lift (Elevator), tangga berjalan (Escalator), ramp, tangga,lift barang (Dumbwaiter) serta travator (Conveyor). Lift (Elevator) adalah suatu alat transportasi untuk mengangkut barang atau penumpang dari satu lantai ke lantai lainnya. Dalam setiap perencanaan lift harus diadakan dengan ketentuan perencanaan yang baik. Rumah sakit adalah sarana yang menyelenggarakan pelayanan jasa kesehatan kepada masyarakat. Untuk memberikan pelayanan yang baik, salah satu alat transportasi vertikal yang harus disediakan adalah lift yang mampu membawa pasien dari lantai satu ke lantaiu lainnya. Dalam penelitian ini, peneliti akan mencoba untuk mengetahui bagaimana kualitas transportasi vertikal dengan menggunakan metode perbandingan antara studi literatur tentang standar perencanaan transportasi vertikal dengan kondisi perencanaan transportasi vertikal (lift) yang ada di lapangan. Dengan mengetahui perbandingan antara literatur standar perencanaan lift dengan kondisi lift yang ada di lapangan maka dapat dikaji suatu persepsi, dengan melakukan perhitungan empiris dari kumpulan data yang ada dengan menggunakan formula hitung; sehingga diperoleh tabel perbandingan antara standar dengan kondisi eksisting lift di lapangan.Pengukuran kualitas transportasi vertikal dengan melakukan evaluasi menggunakan kriteria evaluasi. Penelitian ini menghasilkan kesimpulan bahwa penilaian tingkat keberhasilan pemakaian lift suatu bangunan dalam memberikan kepuasan kepada pemakai terutama untuk penyandang cacat fisik adalah cukup nyaman atau penggunaan elevator (lift) adalah sangat vital.