bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum TNFRII: A promising biomarker for predicting the risk of subcentimetre lung adenocarcinoma
Authors: Hu Minjuan , Zhang Yanwei , Sun Beibei , Lou Yuqing , Zhang Xueyan , Wang Huimin , Huang Chengya , Zhang Wei , Chu Tianqing , Han Baohui 
Published: February 2020

AbstractEarly diagnosis of lung adenocarcinoma requires effective risk predictors. TNFRII was reported to be related to tumorigenesis, but remained unclear in lung cancer. This research set out to investigate the relationship between the sTNFRII (serum TNFRII) level and the risk of lung adenocarcinoma less than 1 cm in diameter. Seventy‐one pairs of subcentimetre lung adenocarcinoma patients and healthy controls were analysed through multiplex bead‐based Luminex assay and found a significantly lower expression of sTNFRII in patients with subcentimetre lung adenocarcinoma than that in the healthy controls (P < .001), which was further verified through ONCOMINE database analysis. Increased levels of sTNFRII reduced the risk of subcentimetre lung adenocarcinoma by 89% (P < .001). Patients with a higher level of BLC had a 2.70‐fold (P < .01) higher risk of subcentimetre adenocarcinoma. Furthermore, a higher BLC/TNFRII ratio was related to a 35‐fold higher risk of subcentimetre adenocarcinoma. TNFRII showed good specificity, sensitivity and accuracy (0.72, 0.75 and 0.73, respectively), with an AUC of 0.73 (P < .001). In conclusion, the present study assessed the value of sTNFRII as a potential biomarker to predict the risk of subcentimetre lung adenocarcinoma and provided evidence for the further use of TNFRII as an auxiliary marker in the diagnosis of subcentimetre lung adenocarcinoma.
The new locally endemic genusYazdana(Caryophyllaceae) and patterns of endemism highlight the high conservation priority of the poorly studied Shirkuh Mountains (central Iran)
Authors: Noroozi Jalil , Pirani Atefeh , Moazzeni Hamid , Mahmoodi Mohammad , Zare Golshan , Noormohammadi Alireza , Barfuss Michael H.J. , Suen Michael , Schneeweiss Gerald M. 
Published: February 2020

AbstractAlthough mountain ranges are often recognized as global biodiversity hotspots with a high level of endemism, diversity and biogeographic connections of isolated and weakly explored mountains remain poorly understood. This is also the case for Shirkuh Mts. in central Iran. Here,Yazdana shirkuhensisgen. & spec. nov. (Caryophylleae, Caryophyllaceae) is described and illustrated from the high alpine zone of this mountain. Molecular phylogenetic analyses of nuclear and plastid DNA sequence data show thatY. shirkuhensisis related toCyathophyllaandHeterochroa(tribe Caryophylleae). The newly described genus and species accentuate Shirkuh Mts. as a center of endemism, which harbors a high number of narrowly distributed species, mostly in high elevations reaching alpine habitats. As this area is currently not protected, a conservation priority is highlighted for high elevations of Shirkuh Mts.
Building plantation America: Creolized design and captive labor in Wright, Faulkner, and Chesnutt
Authors: Emery Mary Lou 
Published: February 2020

AbstractPairing Wright's Auldbrass and Faulkner's Absalom, Absalom! in light of Chesnutt's earlier novel, The House Behind the Cedars, we can read across literature and architecture to foundational myths of plantation America. These myths are embedded in the material structure of the veranda, framed architecturally and also verbally in the structures of literary narrative. However, in these modernist versions of the southern plantation, the myths repeat differently. Like the “guilty secret” screened behind the cedars of Chesnutt's fiction, an obscured global history of captive labor, entwined from its beginnings with creolized architectural design, comes into view. While Chesnutt brings our attention to the “back of the Big House,” Wright and Faulkner's reworkings of the plantation veranda display a contested aesthetic. Echoing the iconic features of the antebellum Big House, they also carry forward an alternate vision, one that counters the rigid patterning and control of racialized labor. Appreciated as “beyond plumb,” this aesthetic recalls different stories, different architects, and the creativity of enslaved plantation workers of earlier centuries.
Effects of phosphogypsum and water treatment residual application on key chemical and biological properties of clay soil and maize yield
Authors: Mahmoud Esawy , Ghoneim Adel , El Baroudy Ahmed , Abd El‐Kader Nasser , Aldhumri ‏Sami Ali , Othman Sanaa , El Khamisy Rasha 
Published: February 2020

AbstractThe reuse of phosphogypsum (PG) and water treatment residual (WTR) waste for agricultural purposes is a possible option to improve the soil properties and increase the crop yield. The present study was conducted during the 2014 growing season in order to determine the impacts ofPGandWTRapplied to the heavy clay soils (which contain more than 50% clay particles) at rates of 5 and 10 t ha−1with the recommended nitrogen fertilizer (NF) on the key soil properties and maize yield. A field experiment was conducted as a randomized complete block design with five treatments and three replications. The treatments were as follows: recommended nitrogen fertilizer (NF);NF+PGat 5.0 t ha−1(NF+PG5);NF+PGat 10.0 t ha−1(NF+PG10);NF+WTRat 5.0 t ha−1(NF+WTR5); andNF+WTRat 10.0 t ha−1(NF+WTR10). The results revealed that the soil microbial biomass carbon (MBC),CO2evolution and dehydrogenase activity (DHA) increased significantly with the addition ofPGorWTR. The application ofPGwithNFat the rate of 10 t ha−1recorded the highest microbial activity, soil available nutrients, grain yield and yield component of maize plants compared to the other treatments. Additions ofNF+PGat the rates of 10 and 5 t ha−1and F+WTRat 10 and 5 t ha−1increasedDHAby 1.70, 1.60, 1.40 and 1.20 times, respectively, compared to theNFtreatment. It can be concluded that application ofPGandWTRwith the recommended application rates would help in improving the properties of heavy clay soils.
Dissociation between Temporal and Spatial Anticipation in the Neural Dynamics of Goal-directed Movement Preparation
Authors: Canaveral Cesar Augusto , Savoie Félix-Antoine , Danion Frédéric R. , Bernier Pierre-Michel 
Published: February 2020

Abstract
It is well documented that providing advanced information regarding the spatial location of a target stimulus (i.e., spatial anticipation) or its timing of occurrence (i.e., temporal anticipation) influences reach preparation, reducing RTs. Yet, it remains unknown whether the RT gains attributable to temporal and spatial anticipation are subtended by similar preparatory dynamics. Here, this issue is addressed in humans by investigating EEG beta-band activity during reach preparation. Participants performed a reach RT task in which they initiated a movement as fast as possible toward visual targets following their appearance. Temporal anticipation was manipulated by having the target appear after a constant or variable delay period, whereas spatial anticipation was manipulated by precueing participants about the upcoming target location in advance or not. Results revealed that temporal and spatial anticipation both reduced reach RTs, with no interaction. Interestingly, temporal and spatial anticipation were associated with fundamentally different patterns of beta-band modulations. Temporal anticipation was associated with beta-band desynchronization over contralateral sensorimotor regions specifically around the expected moment of target onset, the magnitude of which was correlated with RT modulations across participants. In contrast, spatial anticipation did not influence sensorimotor activity but rather led to increased beta-band power over bilateral parieto-occipital regions during the entire delay period. These results argue for distinct states of preparation incurred by temporal and spatial anticipation. In particular, sensorimotor beta-band desynchronization may reflect the timely disinhibition of movement-related neuronal ensembles at the expected time of movement initiation, without reflecting its spatial parameters per se.
Explaining Extreme Events of 2018 from a Climate Perspective
Authors: Herring Stephanie C. , Christidis Nikolaos , Hoell Andrew , Hoerling Martin P. , Stott Peter A. 
Published: February 2020

AbstractEditors note: For easy download the posted pdf of the Explaining Extreme Events of 2018 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.
Development of a measure to assess acceptance of headache: The Headache Acceptance Questionnaire (HAQ)
Authors: Hamer Joshua D , Sackey Enoch T , Maack Danielle J , Smitherman Todd A 
Published: February 2020

Background Disability resulting from headache disorders is attributable in part to avoidant coping. Acceptance of pain connotes a willingness to experience pain in the service of life values, such that meaningful activities and goals are pursued despite pain. Acceptance facilitates positive health outcomes but has rarely been investigated in headache. Because headache disorders manifest differently than other forms of chronic pain, the present study sought to develop and validate a measure of acceptance of headache. Methods Forty-five candidate items were developed and, with input from an expert panel, reduced to 24 items. Five items were eliminated following administration to a development sample and exploratory factory analysis. Nineteen items were administered to a validation sample for confirmatory factory analysis and assessment of psychometric properties. Results Factor analysis produced a unidimensional six-item measure, the Headache Acceptance Questionnaire (HAQ). The HAQ evidenced good internal consistency, convergent validity with headache disability and related psychological constructs, and divergent validity with social desirability. The measure also distinguished between headache diagnostic groups. Conclusions Pending further validation in clinical settings, the HAQ may have utility in assessing psychological responses to headache symptoms, identifying targets of treatment for interventions that focus on reducing avoidance, and studying mechanisms of change.
Prevalence and Burden of Health Problems in Male Elite Ice Hockey Players: A Prospective Study in the Norwegian Professional League
Authors: Nordstrøm Anine , Bahr Roald , Talsnes Ove , Clarsen Ben 
Published: February 2020

Background: As previous epidemiological studies in elite ice hockey have focused on acute time-loss injuries, little is known about the burden of overuse injuries and illnesses in ice hockey. Purpose: To report the prevalence and burden of all health problems in male professional ice hockey players in Norway during a single competitive season. Study Design: Descriptive epidemiological study. Methods: A total of 225 male ice hockey players in the GET League (the premier professional league) in Norway reported all health problems (acute injuries, overuse injuries, and illnesses) during the 2017-2018 competitive season. Players reported all injuries and illnesses for 31 weeks using the Oslo Sports Trauma Research Center Questionnaire on Health Problems. Results: At any given time, 40% (95% CI, 37%-43%) of players reported symptoms from an injury or illness, and 20% (95% CI, 19%-22%) experienced health problems with a substantial negative impact on training and performance. Acute injuries represented the greatest incidence, prevalence, and burden (defined as the cross-product of severity and incidence). The most burdensome acute injuries were to the head/face, shoulder/clavicle, knee, and ankle. The most burdensome overuse injuries were to the knee, lumbar spine, and hip/groin. Conclusion: This registration captured a greater burden from overuse injuries than traditional injury registration, but acute injuries did represent a major problem. These data provide guidance in the development of prevention programs for both acute and overuse injuries, which should focus on the lumbar spine, hip/groin, and knee.
The relationship between metabolic syndrome and the incidence of colorectal cancer
Authors: Lee JungHyun , Lee Kun Sei , Kim Hyeongsu , Jeong Hyoseon , Choi Min-Jung , Yoo Hai-Won , Han Tae-Hwa , Lee Hyunjung 
Published: February 2020

Abstract
Objectives
This study evaluated the incidence of colorectal cancer (CRC) according to the number of metabolic syndrome (MetS) components.

Methods
Using health checkup and insurance claims data of 6,365,409 subjects, the occurrence of CRC according to stage of MetS by sex was determined from the date of the health checkup in 2009 until December 31, 2018.

Results
Cumulative incidence rates (CIR) of CRC in men and women was 3.9 and 2.8 per 1000 (p < 0.001), respectively. CIR of CRC for the normal, pre-MetS, and MetS groups in men was 2.6, 3.9, and 5.5 per 1000 (p < 0.001) and CIR in women was 2.1, 2.9, and 4.5 per 1000 (p < 0.001), respectively. Compared with the normal group, the hazard ratio (HR) of CRC for the pre-MetS group was 1.25 (95% CI 1.17–1.33) in men and 1.09 (95% CI 1.02–1.17) in women, and the HR of CRC for the MetS group was 1.54 (95% CI 1.43–1.65) in men and 1.39 (95% CI 1.26–1.53) in women after adjustment.

Conclusions
We found that MetS is a risk factor for CRC in this study. Therefore, the prevention and active management of MetS would contribute to the prevention of CRC.
Emergence of human avian influenza A(H7N9) virus infections in Wenshan City in Southwest China, 2017
Authors: Jiang Li , Zhao Xiaonan , Xu Wen , Zhou Xuehua , Luo Chunrui , Zhou Jiunan , Fu Xiaoqing , Chen Yaoyao , Li Duo 
Published: February 2020

Abstract
Background
The emergence of human infection with avian influenza A(H7N9) virus was reported in Wenshan City, southwestern China in 2017. The study describes the epidemiological and virological features of the outbreak and discusses the origin of the infection.

Methods
Poultry exposure and timelines of key events for each patient were collected. Samples derived from the patients, their close contacts, and environments were tested for influenza A(H7N9) virus by real-time reverse transcription polymerase chain reaction. Genetic sequencing and phylogenetic analysis were also conducted.

Results
Five patients were reported in the outbreak. An epidemiological investigation showed that all patients had been exposed at live poultry markets. The A(H7N9) isolates from these patients had low pathogenicity in avian species. Both epidemiological investigations of chicken sources and phylogenetic analysis of viral gene sequences indicated that the source of infection was from Guangxi Province, which lies 100 km to the east of Wenshan City.

Conclusions
In the study, a sudden emergence of human cases of H7N9 was documented in urban area of Wenshan City. Chickens were an important carrier in the H7N9 virus spreading from Guangxi to Wenshan. Hygienic management of live poultry markets and virological screening of chickens transported across regions should be reinforced to limit the spread of H7N9 virus.
Supporting quality care for ESRD patients: the social worker can help address barriers to advance care planning
Authors: Senteio Charles R. , Callahan Mary Beth 
Published: February 2020

Abstract
Background
Advance Care Planning (ACP) is essential for preparation for end-of-life. It is a means through which patients clarify their treatment wishes. ACP is a patient-centered, dynamic process involving patients, their families, and caregivers. It is designed to 1) clarify goals of care, 2) increase patient agency over their care and treatments, and 3) help prepare for death. ACP is an active process; the end-stage renal disease (ESRD) illness trajectory creates health circumstances that necessitate that caregivers assess and nurture patient readiness for ACP discussions. Effective ACP enhances patient engagement and quality of life resulting in better quality of care.

Main body
Despite these benefits, ACP is not consistently completed. Clinical, technical, and social barriers result in key challenges to quality care. First, ACP requires caregivers to have end-of-life conversations that they lack the training to perform and often find difficult. Second, electronic health record (EHR) tools do not enable the efficient exchange of requisite psychosocial information such as treatment burden, patient preferences, health beliefs, priorities, and understanding of prognosis. This results in a lack of information available to enable patients and their families to understand the impact of illness and treatment options. Third, culture plays a vital role in end-of-life conversations. Social barriers include circumstances when a patient’s cultural beliefs or value system conflicts with the caregiver’s beliefs. Caregivers describe this disconnect as a key barrier to ACP. Consistent ACP is integral to quality patient-centered care and social workers’ training and clinical roles uniquely position them to support ACP.

Conclusion
In this debate, we detail the known barriers to completing ACP for ESRD patients, and we describe its benefits. We detail how social workers, in particular, can support health outcomes by promoting the health information exchange that occurs during these sensitive conversations with patients, their family, and care team members. We aim to inform clinical social workers of this opportunity to enhance quality care by engaging in ACP. We describe research to help further elucidate barriers, and how researchers and caregivers can design and deliver interventions that support ACP to address this persistent challenge to quality end-of-life care.
Simulation-based mastery learning compared to standard education for discussing diagnostic uncertainty with patients in the emergency department: a randomized controlled trial
Authors: McCarthy Danielle M. , Powell Rhea E. , Cameron Kenzie A. , Salzman David H. , Papanagnou Dimitrios , Doty Amanda MB. , Leiby Benjamin E. , Piserchia Katherine , Klein Matthew R. , Zhang Xiao C. , McGaghie William C. , Rising Kristin L. 
Published: February 2020

AbstractBackgroundDiagnostic uncertainty occurs frequently in emergency medical care, with more than one-third of patients leaving the emergency department (ED) without a clear diagnosis. Despite this frequency, ED providers are not adequately trained on how to discuss diagnostic uncertainty with these patients, who often leave the ED confused and concerned. To address this training need, we developed the Uncertainty Communication Education Module (UCEM) to teach physicians how to discuss diagnostic uncertainty. The purpose of the study is to evaluate the effectiveness of the UCEM in improving physician communications.MethodsThe trial is a multicenter, two-arm randomized controlled trial designed to teach communication skills using simulation-based mastery learning (SBML). Resident emergency physicians from two training programs will be randomly assigned to immediate or delayed receipt of the two-part UCEM intervention after completing a baseline standardized patient encounter. The two UCEM components are: 1) a web-based interactive module, and 2) a smart-phone-based game. Both formats teach and reinforce communication skills for patient cases involving diagnostic uncertainty. Following baseline testing, participants in the immediate intervention arm will complete a remote deliberate practice session via a video platform and subsequently return for a second study visit to assess if they have achieved mastery. Participants in the delayed intervention arm will receive access to UCEM and remote deliberate practice after the second study visit. The primary outcome of interest is the proportion of residents in the immediate intervention arm who achieve mastery at the second study visit.DiscussionPatients’ understanding of the care they received has implications for care quality, safety, and patient satisfaction, especially when they are discharged without a definitive diagnosis. Developing a patient-centered diagnostic uncertainty communication strategy will improve safety of acute care discharges. Although use of SBML is a resource intensive educational approach, this trial has been deliberately designed to have a low-resource, scalable intervention that would allow for widespread dissemination and uptake.Trial registrationThe trial was registered at clinicaltrials.gov (NCT04021771). Registration date: July 16, 2019.
Comparative value of a simulation by gaming and a traditional teaching method to improve clinical reasoning skills necessary to detect patient deterioration: a randomized study in nursing students
Authors: Blanié Antonia , Amorim Michel-Ange , Benhamou Dan 
Published: February 2020

Abstract
Background
Early detection and response to patient deterioration influence patient prognosis. Nursing education is therefore essential. The objective of this randomized controlled trial was to compare the respective educational value of simulation by gaming (SG) and a traditional teaching (TT) method to improve clinical reasoning (CR) skills necessary to detect patient deterioration.

Methods
In a prospective multicenter study, and after consent, 2nd year nursing students were randomized into two groups:
Simulation by gaming “SG”: the student played individually with a serious game consisting of 2 cases followed by a common debriefing with an instructor;Traditional Teaching “TT”: the student worked on the same cases in text paper format followed by a traditional teaching course with a PowerPoint presentation by an instructor.
CR skill was measured by script concordance tests (80 SCTs, score 0–100) immediately after the session (primary outcome) and on month later. Other outcomes included students’ satisfaction, motivation and professional impact.

Results
One hundred forty-six students were randomized. Immediately after training, the SCTs scores were 59 ± 9 in SG group (n = 73) and 58 ± 8 in TT group (n = 73) (p = 0.43). One month later, the SCTs scores were 59 ± 10 in SG group (n = 65) and 58 ± 8 in TT group (n = 54) (p = 0.77). Global satisfaction and motivation were highly valued in both groups although significantly greater in the SG group (p < 0.05). The students declared that the training course would have a positive professional impact, with no difference between groups.

Conclusions
In this study assessing nursing student CR to detect patient deterioration, no significant educational difference (SCT), neither immediate nor 1 month later, was observed between training by SG and the TT course. However, satisfaction and motivation were found to be greater with the use of SG.

Trial registration
ClinicalTrials.gov; NCT03428269. Registered 30 january 2018.