bluuebunny/crossref_metadata_2025_split huggingface dataset:
A weekly spatio‐temporal distribution of drought events over the Po Plain (North Italy) in the last five decades
Authors: Baronetti Alice , González‐Hidalgo José Carlos , Vicente‐Serrano Sergio M. , Acquaotta Fiorella , Fratianni Simona 
Published: December 2019

AbstractThe aim of this research is to identify and characterize, in terms of length, intensity, and spatial propagation, the main drought events which took place in the Po Valley (Italy) from 1965 to 2017. Two drought indices were applied, the Standardized Precipitation Evapotranspiration Index (SPEI) and Standardized Precipitation Index (SPI). Daily precipitation and temperature series belonging to the National System for the Collection, Processing, and Dissemination of Climatic Data of Environmental Interest (SCIA) database were collected. Subsequent to an accurate quality control, the converted weekly climatic values were spatialized on a 20 × 20 km cell grid, and for each index, weekly severe and extreme drought episodes at a 12‐, 24‐, and 36‐month time scale were calculated. Results showed that the application of two indices is fundamental in the study of drought episodes, and that different triggering factors act over time. Especially, since the 2001 drought, episodes have become stronger in terms of frequency and length, and they seem to be mostly related to changes in the intra‐annual precipitation distribution. An analysis of the spatial propagation also indicates that two spatial gradients follow each other during the analysed period.
Retracted: MiR‐194‐5p inhibited metastasis and EMT of nephroblastoma cells through targeting Crk
Authors: Liu Hong , Ren Shi‐Ying , Qu Yan , Liu Cui , Zhang Yi , Li Xiang Qing , Ma Hong 
Published: December 2019

AbstractWilms tumor (WT) is the most common solid childhood tumors all over the world. MicroRNAs (miRs) contribute to tumorigenesis of various cancers through targeting gene. The present study investigated the vital role of miR‐194‐5p and its underlying mechanism in the progression of WT. Immunohistochemistry and quantitative real‐time polymerase chain reaction (qRT‐PCR) assay indicated downregulation of miR194‐5p and upregulation of Crk, in WT tissues compared to adjacent normal tissues. Transfection with miR‐194‐5p mimics into nephroblastoma cells showed a significant decline in cell migration and invasion, which was detected by Transwell assay. Luciferase assay confirmed that Crk was a direct target gene of miR‐194‐5p. More important, the mesenchymal to epithelial transition (EMT) biomarkers containing E‐cadherin, N‐cadherin and Zeb1 were examined by Western blot, and revealed that miR‐194‐5p mimics decreased the levels of N‐cadherin and Zeb1 but increased E‐cadherin, which suggested that miR‐194‐5p inhibited EMT. Crk knockdown could reverse the increased nephroblastoma cell invasion, migration and EMT caused by miR‐194‐5p inhibitor. Interestingly, qRT‐PCR and Western blot analysis showed that overexpression of miR‐194‐5p deactivated HGF/c‐Met/Scr signaling pathway via targeting Crk. In conclusion, miR‐194‐5p inhibited nephroblastoma cell metastasis and EMT in the progression of WT by targeting Crk. Thus, miR‐194‐5p might be a potential target in WT particularly for the prevention of metastasis and EMT.
Superoxide imbalance triggered by Val16Ala‐SOD2 polymorphism increases the risk of depression and self‐reported psychological stress in free‐living elderly people
Authors: da Cruz Jung Ivo Emilio , da Cruz Ivana Beatrice Mânica , Barbisan Fernanda , Trott Alexis , Houenou Lucien J. , Osmarin Turra Bárbara , Duarte Thiago , de Souza Praia Raquel , Maia‐Ribeiro Ednea Aguiar , da Costa Escobar Piccoli Jaqueline , Bica Claudia Giugliano , Duarte Marta Maria Medeiros Frescura 
Published: December 2019

AbstractBackgroundOxidative stress and chronic inflammatory states triggered by a single‐nucleotide polymorphism (SNP) in superoxide dismutase manganese‐dependent gene (Val16Ala‐SOD2) have been associated with the risk of developing several chronic, nontransmissible diseases. However, it is still not clear whether the VV‐SOD2 genotype that causes higher basal superoxide anion levels has any impact on the risk for depression and self‐reported psychological stress in elderly people.MethodsIn the present study, we tested this hypothesis using a case‐control study where depression was detected using the Geriatric Depression Scale‐15 (GDS‐15). A total of 612 Brazilian free‐living elderly subjects with a mean age of 67.1 ± 7.1 years old (number of controls, C = 497, and depressive individuals, D = 115) were included in this study. All participants had similar social, health, and lifestyle variables, with the exception of polypharmacy (≥5 medicines daily intake), which was higher in the D group, compared to C subjects.ResultsOur results showed that the VV‐SOD2 genotype significantly increased the risk for depression and psychological stress in the elderly subjects, independently of sex/gender, age, and other prior diseases and health indicators (depression risk = 1.842, 1.109–3.061 95% CI, p = .018). VV‐subjects also had a higher daily intake of antidepressants, anxiolytics, and anti‐inflammatory drugs than A‐allele subjects.ConclusionOur findings support the hypothesis that genetically induced oxidative superoxide‐hydrogen peroxide imbalance may be involved in an increased risk for developing depression and psychological stress in free‐living elderly people without other chronic nontransmissible diseases.
Performance of semiconductor dosimeters with a range of radiation qualities used for mammography: A calibration laboratory study
Authors: Salomon Elisabeth , Homolka Peter , Csete Istvan , Toroi Paula 
Published: December 2019

PurposeTo investigate the radiation quality dependence of the response of commercial semiconductor‐based dosimeters, and to estimate potential errors and uncertainties related to different measurement and calibration scenarios.MethodsAll measurement results were compared to reference values measured at the IAEA dosimetry laboratory which is traceable to the international system of units (SI). Energy dependence of the response of eight semiconductor dosimeters were determined for five different anode‐filter combinations and tube voltages from 25 to 35 kV. For systems capable of deriving half value layer (HVL) and tube voltage from measurements, calibration coefficients for these measurements were calculated.ResultsFor six dosimeters, the maximum deviations from the reference value of the air kerma measurement were within ±5% as required by IEC 61674. Calibration coefficients for radiation qualities (anode‐filter and tube voltage combinations) relative to reference radiation quality Mo‐Mo 28 kV deviate up to 12%. HVL and tube voltage measurements exhibited deviations up to 11% and 10%, respectively.ConclusionsThe air kerma responses of modern semiconductor dosimeters have a small energy dependence. However, no dosimeter tested complied with the accuracy limits stated by the manufacturer for tube voltage measurements, and only two dosimeters complied with the limits for HVL measurements. Absolute measurement of HVL and tube voltage with semiconductor dosimeters have to be verified for actual clinical radiation conditions on clinical mammography systems. Semiconductor dosimeters can be used for quality control measurements if individual calibration coefficients are available for the radiation condition applied. If other conditions are applied, additional uncertainty needs to be considered, particularly in the case of HVL and tube voltage measurements.
Body Composition During Pregnancy Differs by Obesity Class
Authors: Most Jasper , Altazan Abby D. , Hsia Daniel S. , Beyl Robbie A. , Redman Leanne M. 
Published: December 2019

ObjectiveThe aim of this study is to characterize changes in body composition during pregnancy in women with obesity.MethodsFifty‐four healthy women with obesity (class 1, 30‐34.9 kg/m2: n = 25; class 2, 35‐39.9 kg/m2: n = 21; class 3, ≥ 40.0 kg/m2: n = 8) expecting a singleton pregnancy were studied. Body composition was measured in early pregnancy (13‐16 weeks), midpregnancy (24‐27 weeks), and late pregnancy (35‐37 weeks) using air displacement plethysmography, stable isotopes, and skinfold thickness measurements. Fasting glucose, insulin, and leptin were measured.ResultsThe gain in fat‐free mass was lower in the second trimester compared with the third (2.7 ± 0.2 to 5.3 ± 0.2 kg; P < 0.001), whereas fat mass accumulation declined over time (0.6 ± 0.3 to −0.7 ± 0.4 kg; P = 0.005). Women with class 1 and 2 obesity gained 1.1 ± 0.7 kg of fat mass during pregnancy, while women with class 3 obesity lost 4.1 ± 0.6 kg (both P < 0.001). The difference in fat accumulation between obesity classes was observed only in the second trimester (P = 0.02). Gestational weight gain was associated positively with changes in plasma concentrations of insulin, leptin, and insulin resistance (all P < 0.01).ConclusionsGestational weight gain in pregnancy differs by obesity class and trimester. Women with class 3 obesity gain less body weight and fat mass. Fat mass gain is most likely preventable in the second trimester.
Experimental investigation of spilling fire spread over steady flow n‐butanol fuel: Effects of flow speed and spreading direction
Authors: Pan Yang , Li Manhou , Wang Changjian , Luo Xinjiao , Luo Qiuting 
Published: December 2019

AbstractStudying on the behaviors and mechanisms involving liquid spilling fire is imperative issue in the accident investigations, safety management, risk assessment, and fire analysis of petroleum products. The experimental investigations of spilling fire spread over steady flow n‐butanol fuel under different discharge flow rates and spreading directions (opposed and concurrent spreading) were conducted based upon a self‐developed laboratory‐scale apparatus. Several parameters were revealed to characterize the steady flow fire namely flame brightness, flame height, and relative velocity of spilling fire to flow speed (Vf − u). The fluid dynamic analysis of continuously spilling fuel was performed to find out the relationship of the flow speed and the discharge flow rate. The spilling fires at different flow speeds were separated into four regimes: (I) retardation regime and (II) nonspreading regime in opposed flow, and (III) acceleration regime and (IV) detachment regime in concurrent flow. The parametric variation and the inherent mechanism were discussed to reveal the effects of the discharge flow rate and spreading direction on the liquid spilling fire. The findings of the present research are beneficial for the development of the fuel spilling fire protection measures.
The effect of a leading edge erosion shield on the aerodynamic performance of a wind turbine blade
Authors: Kyle Ryan , Wang Fan , Forbes Brian 
Published: December 2019

AbstractArmour EDGE is a novel shield developed to protect the leading edge of wind turbine blades from erosion. The aerodynamic impact on aerofoils of National Renewable Energy Laboratory (NREL) 5MW wind turbine has been investigated using 2D fully turbulent computational fluid dynamics (CFD), with three profiles at critical locations along the blade simulated both with and without the shield to compare aerodynamic performance. Two wind speeds were investigated that reflect regular operating conditions: at rated speed of 11.4 m/s and a below rated speed of 7 m/s. The results showed that the presence of the shield during rated wind speed reduced the drag by as much as 4.5%, where the lift‐to‐drag ratio increased by a maximum of 4%. At the below rated wind speeds, the shield had negligible impact on the performance of all but one National Advisory Committee for Aeronautics (NACA) 64‐618 profile, which resulted in an increase in the drag coefficient of 7%. It was also found that the suction side of the aerofoil is much more sensitive to leading edge protection placement than the pressure side. It was concluded that the erosion shield as a method of leading edge protection, with a gradual transition from shield to blade, will not have a major impact on the aerodynamic performance of a multi‐megawatt wind turbine blade and could slightly increase aerofoil efficiency at high wind speeds.
Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
Authors: Losko Magdalena , Dolicka Dobrochna , Pydyn Natalia , Jankowska Urszula , Kedracka-Krok Sylwia , Kulecka Maria , Paziewska Agnieszka , Mikula Michal , Major Piotr , Winiarski Marek , Budzynski Andrzej , Jura Jolanta 
Published: December 2019

AbstractObesity is considered a serious chronic disease, associated with an increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1) is an RNase decreasing stability of transcripts coding for inflammation-related proteins. In addition, MCPIP1 plays an important role in the regulation of adipogenesis in vitro by reducing the expression of key transcription factors, including C/EBPβ. To elucidate the role of MCPIP1 in adipocyte biology, we performed RNA-Seq and proteome analysis in 3T3-L1 adipocytes overexpressing wild-type (WTMCPIP1) and the mutant form of MCPIP1 protein (D141NMCPIP1). Our RNA-Seq analysis followed by confirmatory Q-RT-PCR revealed that elevated MCPIP1 levels in 3T3-L1 adipocytes upregulated transcripts encoding proteins involved in signal transmission and cellular remodeling and downregulated transcripts of factors involved in metabolism. These data are consistent with our proteomic analysis, which showed that MCPIP1 expressing adipocytes exhibit upregulation of proteins involved in cellular organization and movement and decreased levels of proteins involved in lipid and carbohydrate metabolism. Moreover, MCPIP1 adipocytes are characterized by decreased level of insulin receptor, reduced insulin-induced Akt phosphorylation, as well as depleted Glut4 level and impaired glucose uptake. Overexpression of Glut4 in 3T3-L1 cells expressed WTMCPIP1 rescued adipogenesis. Interestingly, we found decreased level of MCPIP1 along with an increase in body mass index in subcutaneous adipose tissue. The presented data show a novel role of MCPIP1 in modulating insulin sensitivity in adipocytes. Overall, our findings demonstrate that MCPIP1 is an important regulator of adipogenesis and adipocyte metabolism.
Parental magma, magmatic stratigraphy, and reef-type PGE enrichment of the 2.44-Ga mafic-ultramafic Näränkävaara layered intrusion, Northern Finland
Authors: Järvinen Ville , Halkoaho Tapio , Konnunaho Jukka , Heinonen Jussi S. , Rämö O. Tapani 
Published: December 2019

AbstractAbout 20 mafic-ultramafic layered intrusions in the northern Fennoscandian shield were emplaced during a widespread magmatic event at 2.5–2.4 Ga. The intrusions host orthomagmatic Ni-Cu-PGE and Cr-V-Ti-Fe deposits. We update the magmatic stratigraphy of the 2.44-Ga Näränkävaara mafic-ultramafic body, northeastern Finland, on the basis of new drill core and outcrop observations. The Näränkävaara body consists of an extensive basal dunite (1700 m thick), and a layered series comprising a peridotitic–pyroxenitic ultramafic zone (600 m thick) and a gabbronoritic–dioritic mafic zone (700 m thick). Two reversals are found in the layered series. The composition of the layered series parental magma was approximated using a previously unidentified marginal series gabbronorite. The parental magma was siliceous high-Mg basalt with high MgO, Ni, and Cr, but also high SiO2 and Zr, which suggests primary magma contamination by felsic crust. Cu/Pd ratio below that of primitive mantle implies PGE-fertility. The structural position of the marginal series indicates that the thick basal dunite represents an older wallrock for the layered intrusion. A subeconomic reef-type PGE-enriched zone is found in the border zone between the ultramafic and mafic zones and has an average thickness of 25 m with 150–250 ppb of Pt + Pd + Au. Offset-type metal distribution and high sulfide tenor (50–300 ppm Pd) and R-factor (105) suggest reef formation by sulfide saturation induced by fractional crystallization. The reef-forming process was probably interrupted by influx of magma related to the first reversal. Metal ratios suggest that this replenishing magma was PGE-depleted before emplacement.
Physical working conditions and subsequent disability retirement due to any cause, mental disorders and musculoskeletal diseases: does the risk vary by common mental disorders?
Authors: Halonen Jaana I. , Mänty Minna , Pietiläinen Olli , Kujanpää Tero , Kanerva Noora , Lahti Jouni , Lahelma Eero , Rahkonen Ossi , Lallukka Tea 
Published: December 2019

Abstract
Purpose
Physical work exposures and common mental disorders (CMD) have been linked to increased risk of work disability, but their joint associations with disability retirement due to any cause, mental disorders or musculoskeletal diseases have not been examined.

Methods
The data for exposures and covariates were from the Finnish Helsinki Health Study occupational cohort surveys in 2000–2002, 2007 and 2012. We used 12,458 observations from 6159 employees, who were 40–60 years old at baseline. CMD were measured by the General Health Questionnaire (GHQ-12, cut-off point 3+). Four self-reported work exposures (hazardous exposures, physical workload, computer and shift work) were combined with CMD and categorized as “neither”, “work exposure only”, “CMD only”, and “both”. Associations with register-based disability retirement were assessed with Cox proportional hazards models for sample survey data adjusting for confounders over 5-year follow-up. Additionally, synergy indices were calculated for the combined effects.

Results
Those reporting CMD and high physical workload had a greater risk of disability retirement due to any cause (HR 4.26, 95% CI 3.60–5.03), mental disorders (HR 5.41, 95% CI 3.87–7.56), and musculoskeletal diseases (HR 4.46, 95% CI 3.49–5.71) when compared to those with neither. Synergy indices indicated that these associations were synergistic. Similar associations were observed for CMD and hazardous exposures, but not for combined exposures to CMD and computer or shift work.

Conclusions
Identification of mental health problems among employees in physically demanding jobs is important to support work ability and reduce the risk of premature exit from work due to disability.
Technoperformances: using metaphors from the performance arts for a postphenomenology and posthermeneutics of technology use
Authors: Coeckelbergh Mark 
Published: December 2019

AbstractPostphenomenology and posthermeneutics as initiated by Ihde have made important contributions to conceptualizing understanding human–technology relations. However, their focus on individual perception, artifacts, and static embodiment has its limitations when it comes to understanding the embodied use of technology as (1) involving bodily movement, (2) social, and (3) taking place within, and configuring, a temporal horizon. To account for these dimensions of experience, action, and existence with technology, this paper proposes to use a conceptual framework based on performance metaphors. Drawing on metaphors from three performance arts—dance, theatre, and music—and giving examples from social media and other technologies, it is shown that we can helpfully describe technology use and experience as performance involving movement, sociality, and temporality. Moreover, it is argued that these metaphors can also be used to reformulate the idea that in such uses and experiences, now understood as “technoperformances”, technology is not merely a tool but also takes on a stronger, often non-intended role: not so much as “mediator” but as choreographer, director, and conductor of what we experience and do. Performance metaphors thus allow us to recast the phenomenology and hermeneutics of technology use as moving, social, and temporal—indeed historical—affair in which technologies take on the role of organizer and structurer of our performances, and in which humans are not necessarily the ones who are fully in control of the meanings, experiences, and actions that emerge from our engagement with the world, with technology, and with each other. This promises to give us a more comprehensive view of what it means to live with technology and how our lives are increasingly organized by technology—especially by smart technologies. Finally, it is argued that this has normative implications for an ethics and politics of technology, now understood as an ethics and politics of technoperformances.
Papal visits and abortions: evidence from Italy
Authors: Farina Egidio , Pathania Vikram 
Published: December 2019

AbstractWe investigate the impact of papal visits to Italian provinces on abortions from 1979 to 2012. Using administrative data, we find a 10–20% decrease in the number of abortions that commences in the 3rd month and persists until the 14th month after the visits. However, we find no significant change in the number of live births. A decline in unintended pregnancies best explains our results. Papal visits generate intense local media coverage, and likely make salient the Catholic Church’s stance against abortions. We show that papal visits lead to increased church attendance, and that the decline in abortions is greater when the Pope mentions abortion in his speeches.
Multivariate Gaussian and Student-t process regression for multi-output prediction
Authors: Chen Zexun , Wang Bo , Gorban Alexander N. 
Published: December 2019

AbstractGaussian process model for vector-valued function has been shown to be useful for multi-output prediction. The existing method for this model is to reformulate the matrix-variate Gaussian distribution as a multivariate normal distribution. Although it is effective in many cases, reformulation is not always workable and is difficult to apply to other distributions because not all matrix-variate distributions can be transformed to respective multivariate distributions, such as the case for matrix-variate Student-t distribution. In this paper, we propose a unified framework which is used not only to introduce a novel multivariate Student-t process regression model (MV-TPR) for multi-output prediction, but also to reformulate the multivariate Gaussian process regression (MV-GPR) that overcomes some limitations of the existing methods. Both MV-GPR and MV-TPR have closed-form expressions for the marginal likelihoods and predictive distributions under this unified framework and thus can adopt the same optimization approaches as used in the conventional GPR. The usefulness of the proposed methods is illustrated through several simulated and real-data examples. In particular, we verify empirically that MV-TPR has superiority for the datasets considered, including air quality prediction and bike rent prediction. At last, the proposed methods are shown to produce profitable investment strategies in the stock markets.