bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decline of coronary heart disease mortality is strongly effected by changing patterns of underlying causes of death: an analysis of mortality data from 27 countries of the WHO European region 2000 and 2013
Authors: Stolpe Susanne , Kowall Bernd , Stang Andreas 
Published: November 2020

AbstractMortality rates for coronary heart disease (CHD) experience a longstanding decline, attributed to progress in prevention, diagnostics and therapy. However, CHD mortality rates vary between countries. To estimate whether national patterns of causes of death impact CHD mortality, data from the WHO “European detailed mortality database” for 2000 and 2013 for populations aged ≥ 80 years was analyzed. We extracted mortality rates for total mortality, cardiovascular diseases, neoplasms, dementia and ill-defined causes. We calculated proportions of selected causes of death among all deaths, and proportions of selected cardiovascular causes among cardiovascular deaths. CHD mortality rates were recalculated after re-coding ill-defined causes of death. Association between CHD mortality rates and proportions of CHD deaths was estimated by population-weighted linear regression. National patterns of causes of death were divers. In 2000, CHD was assigned as cause of death in 13–53% of all cardiovascular deaths. Until 2013, this proportion changed between − 65% (Czech Republic) and + 57% (Georgia). Dementia was increasingly assigned as underlying cause of death in Western Europe, but rarely in eastern European countries. Ill-defined causes accounted for between < 1% and 53% of all cardiovascular deaths. CHD mortality rates were closely linked to a countries’ proportion of cardiovascular deaths assigned to CHD (R2 = 0.95 for 2000 and 0.99 for 2013). We show that CHD mortality is considerably influenced by national particularities in certifying death. Changes in CHD mortality rates reflect changes in certifying competing underlying causes of death. This must be accounted for when discussing reasons for the CHD mortality decline.
Green purchasing: the effect of parenthood and gender
Authors: Migheli Matteo 
Published: November 2020

AbstractThe extant literature has inquired the effect of several socio-economic individual characteristics on green purchasing, showing that education, social status and other individual characteristics may enhance virtuous behaviours, but has paid few attention to parenthood and to the presence of children. Theoretical models of microeconomic choices show that if the parents’ utility includes that of children, then their presence should affect parents’ green purchases. Indeed, parents should desire a sustainable world for their children to have access to enough resources. Using data from 61 countries, this paper inquires whether parenthood and the number of children affect people’s decisions about green consumption; in addition the presence of a gender effect (i.e. mothers being more prone to green choices than fathers) exists. The empirical evidence shows that having children decreases the probability of buying green products; an increasing number of children have the same effect. However, parenthood and number of children have opposite effects on fathers and on mothers. Policymakers and marketing divisions of firms may benefit from this empirical evidence. In addition, analyses are performed on homogeneous clusters of countries to account for possible differences due to different environmental engagement or level of economic development. The results show that, while the gender effect is persistent, that of parenting and the number of children is not statistically significant in affluent countries. This last result suggests that budget constraints are a major factor affecting green purchases.
Ultrasmall gold and silver/gold nanoparticles (2 nm) as autofluorescent labels for poly(D,L-lactide-co-glycolide) nanoparticles (140 nm)
Authors: Wey Karolin , Epple Matthias 
Published: November 2020

AbstractUltrasmall metallic nanoparticles show an efficient autofluorescence after excitation in the UV region, combined with a low degree of fluorescent bleaching. Thus, they can be used as fluorescent labels for polymer nanoparticles which are frequently used for drug delivery. A versatile water-in-oil-in-water emulsion-evaporation method was developed to load poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles with autofluorescent ultrasmall gold and silver/gold nanoparticles (diameter 2 nm). The metallic nanoparticles were prepared by reduction of tetrachloroauric acid with sodium borohydride and colloidally stabilised with 11-mercaptoundecanoic acid. They were characterised by UV–Vis and fluorescence spectroscopy, showing a large Stokes shift of about 370 nm with excitation maxima at 250/270 nm and emission maxima at 620/640 nm for gold and silver/gold nanoparticles, respectively. The labelled PLGA nanoparticles (140 nm) were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), and UV–Vis and fluorescence spectroscopy. Their uptake by HeLa cells was followed by confocal laser scanning microscopy. The metallic nanoparticles remained inside the PLGA particle after cellular uptake, demonstrating the efficient encapsulation and the applicability to label the polymer nanoparticle. In terms of fluorescence, the metallic nanoparticles were comparable to fluorescein isothiocyanate (FITC).
Evaluation of the antimicrobial activity and compressive strength of a dental cement modified using plant extract mixture
Authors: Singer Lamia , Bierbaum Gabriele , Kehl Katja , Bourauel Christoph 
Published: November 2020

AbstractLiterature lacks sufficient data regarding addition of natural antibacterial agents to glass ionomer cement (GICs). Hence, the aim of the study was to increase the antimicrobial properties of GICs through its modification with mixture of plant extracts to be evaluated along with an 0.5% chlorohexidine-modified GIC (CHX-GIC) with regard to biological and compressive strength properties. Conventional GIC (freeze-dried version) and CHX were used. Alcoholic extract of Salvadora persica, Olea europaea, and Ficus carcia leaves were prepared using a Soxhlet extractor for 12 h. The plant extract mixture (PE) was added in three different proportions to the water used for preparation of the dental cement (Group 1:1 PE, 2:1 PE, and 1:2 PE). Specimens were then prepared and tested against the unmodified GIC (control) and the 0.5% CHX-GIC. Chemical analysis of the extract mixture was performed using Gas chromatography–mass spectrometry. Antimicrobial activity was evaluated using agar diffusion assay against Micrococcus luteus and Streptoccocus mutans. Compressive strength was evaluated according to ISO 9917-1:2007 using a Zwick testing machine at a crosshead speed of 0.5 mm/min. Antimicrobial activity against Streptoccocus mutans was significantly increased for all the extract-modified materials compared to the unmodified cement, and the highest concentration was comparable to the CHX-GIC mixture. The activity against Micrococcus luteus was also significantly increased, but only for the material with the highest extract concentration, and here the CHX-GIC group showed statistically the highest antimicrobial activity. Compressive strength results revealed that there was no statistically significant difference between the different mixtures and the control except for the highest tested concentration that showed the highest mean values. The plant extracts (PEs) enhanced the antimicrobial activity against S. mutans and also against M. luteus in the higher concentration while compressive strength was improved by addition of the PE at higher concentrations.
Using the Wilder Collaboration Factors Inventory to Strengthen Collaborations for Improving Maternal and Child Health
Authors: Wells Rebecca , Yates Lindsey , Morgan Isabel , deRosset Leslie , Cilenti Dorothy 
Published: November 2020

Abstract
Introduction
The Wilder Collaboration Factors Inventory is a free, publicly available questionnaire about the quality and context of community collaboration. The purpose of this article is to share lessons from using this questionnaire in a North Carolina maternal and child health initiative.

Methods
In 2015, the State’s General Assembly funded five local health departments to implement evidence-based strategies for improving maternal and child health. Each health department formed a community action team for this purpose. Members of each community action team completed the Wilder Collaboration Factors Inventory (Inventory) in the first year of funding and again 1 and 2 years later. Technical assistance coaches also asked community action team conveners to complete a brief questionnaire annually, and used these as well as Inventory results to plan for improvements.

Results
During the first year, community action teams emerged as strong in seeing collaboration in their self-interest. A primary challenge noted by conveners was engaging consumers on the community action teams. Strategies to address this included using social media and compensating consumers for attending meetings. By the second year, teams’ average scores in engaging multiple layers of participation increased, and eight additional factors became strengths, which generally continued in year three. The most consistent challenge was supporting community action teams administratively.

Discussion
The Wilder Collaboration Factors Inventory provided a feasible tool for identifying opportunities for improvement in several local, cross-sector partnerships, suggesting promise for other communities seeking to enhance their collective impact on maternal and child health.
RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage
Authors: Zhou Huiling , Liu Lijun , Ma Xiaolong , Wang Jian , Yang Jinfu , Zhou Xinmin , Yang Yifeng , Liu Haidan 
Published: November 2020

AbstractVinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial damage has been continually reported. The underlying molecular mechanism of the myocardial damage remains unknown. Here, we show that vinblastine induces myocardial damage and necroptosis is involved in the vinblastine-induced myocardial damage both in vitro and in vivo. The results of WST-8 and flow cytometry analysis show that vinblastine causes damage to H9c2 cells, and the results of animal experiments show that vinblastine causes myocardial cell damage. The necrosome components, receptor-interacting protein 1 (RIP1) receptor-interacting protein 3 (RIP3), are significantly increased in vinblastine-treated H9c2 cells, primary neonatal rat ventricular myocytes and rat heart tissues. And the downstream substrate of RIP3, mixed lineage kinase domain like protein (MLKL) was also increased. Pre-treatment with necroptosis inhibitors partially inhibits the necrosome components and MLKL levels and alleviates vinblastine-induced myocardial injury both in vitro and in vivo. This study indicates that necroptosis participated in vinblastine-evoked myocardial cell death partially, which would be a potential target for relieving the chemotherapy-related myocardial damage.
Process design for 5-axis ball end milling using a real-time capable dynamic material removal simulation
Authors: Denkena B. , Pape O. , Krödel A. , Böß V. , Ellersiek L. , Mücke A. 
Published: November 2020

AbstractFor repairing turbine blades or die and mold forms, additive manufacturing processes are commonly used to build-up new material to damaged sections. Afterwards, a subsequent re-contouring process such as 5-axis ball end milling is required to remove the excess material restoring the often complex original geometries. The process design of the re-contouring operation has to be done virtually, because the individuality of the repair cases prevents actual running-in processes. Hard-to-cut materials e.g. titanium or nickel alloys, parts prone to vibration and long tool holders complicate the repair even further. Thus, a fast and flexible material removal simulation is needed. The simulation has to predict suitable processes focusing shape deviations under consideration of process stability for arbitrary complex engagement conditions. In this paper, a dynamic multi-dexel based material removal simulation is presented, which is able to predict high-resolution surface topography and stable parameters for arbitrary processes such as 5-axis ball end milling. In contrast to other works, the simulation is able to simulate an unstable process using discrete cutting edges in real-time.
Gaze Control in Law Enforcement: Comparing a Tactical Police Unit to Patrol Officers
Authors: Heusler Benedikt , Sutter Christine 
Published: November 2020

AbstractPolice officers strongly rely on their ability to visually perceive threats accurately and quickly on a daily basis. Previous studies have shown that training and practical experience improve performance in life-threatening encounters. The present study compared the gaze patterns of highly trained police officers of a tactical unit (TU) to matched patrol officers (MP) and unmatched patrol officers (UP) in realistic video scenarios using a mobile eye tracker and a USB arcade gun. As hypothesized, the TU fixated the tactically crucial hands and hip region of a suspect significantly longer than the MP and UP. Vice versa, the MP and UP fixated the suspect’s face significantly longer than the TU. The results indicate that tactical training enhances efficient gaze control to a greater extent than practical routine. Therefore, the authors recommend regular training and education on this topic for law enforcement personnel to minimize the risk of death or severe injuries in high-stress situations.
Sleep and Memory in Children
Authors: Hoedlmoser Kerstin 
Published: November 2020

AbstractPurpose of ReviewThis short review article aims at emphasizing interesting and important new insights about investigating sleep and memory in children aged between 6 and 13 years (middle childhood).Recent FindingsThat sleep in comparison to wakefulness benefits the consolidation of memories is well established—especially for the adult population. However, the underlying theoretical frameworks trying to explain the benefits of sleep for memory still strive for more substantiate findings including biological and physiological correlates.SummaryBased on the most recent literature about sleep-related memory consolidation and its physiological markers during middle childhood, this article provides a review and highlights recent updates in this field.
Developing an inclusive Safe Dates program for sexual and gender minority adolescents: A pilot study
Authors: Wesche Rose , Galletly Carol L. , Shorey Ryan C. 
Published: November 2020

ABSTRACTIntroductionDespite the prevalence and negative consequences of dating violence among sexual and gender minority (SGM) adolescents, few prevention programs address dating violence for these groups. We describe the adaptation of the evidence‐based Safe Dates dating violence prevention program to be inclusive of SGM adolescents and the outcome of a pilot trial of the expanded curriculum implemented in mixed settings serving both SGM and cisgender, heterosexual youth.MethodsFollowing a published framework of curriculum adaptation, we gathered information on SGM adolescents’ needs and adapted Safe Dates materials to address SGM‐specific risk factors for, and manifestations of, dating violence. We piloted the adapted program in 11 US schools and organizations serving SGM and cisgender, heterosexual youth (N = 156). The average age of participants was 15.11 years (SD = 2.76) at baseline. Participants were diverse with respect to race/ethnicity (26% Black/African American, 24% Hispanic/Latino, 21% White, 7% American Indian/Native Alaskan, 5% Asian/Pacific Islander), gender (56% female), and SGM status (35% SGM). Multi‐level models measured change in scores on a written measure of dating violence knowledge from pre‐test to post‐test.ResultsDating violence knowledge increased significantly. Improvements did not differ by gender (female‐identified versus not female‐identified) or SGM status.ConclusionsResults support initial feasibility and efficacy of dating violence prevention programs that include both SGM and cisgender, heterosexual adolescents. The program normalizes diverse SGM identities and encourages participation of youth who are questioning or choosing not to disclose their gender or sexual identities. Larger‐scale research should examine effects on dating violence experiences.
‘Treatable and Changeable’: The Effect of Treatment and Malleability Information on Stigma Towards Children with Behavioural Problems and Their Parents
Authors: Li Sarah , Tully Lucy , Dadds Mark R. 
Published: December 2020

AbstractImproving knowledge about childhood mental health issues, reducing stigma, and encouraging appropriate treatment-seeking are important goals for public health. This study examined the effect of treatment and malleability information on stigmatisation towards children with Oppositional Defiant Disorder (ODD) and their parents, and on endorsements of causal beliefs. In an experimental study, university students (N = 234) were randomly allocated to receive/not receive treatment information (information on the existence and effectiveness of treatment for ODD) and to receive/not receive malleability information (information emphasising brain malleability and the potential to change). Participants then rated four measures of stigma towards a fictitious child with ODD and mother (blame, incompetence, dangerousness, and social distance), and rated their endorsements of causal explanations for ODD. Neither treatment nor malleability information had significant effects on stigmatisation towards either the child or mother. However, this information did impact upon causal beliefs about ODD as stemming from biological or mixed biological/environmental causes. Implications for the future development of public health initiatives and stigma research on childhood mental health are discussed.
Conditions of Loss Cone Filling by Scattering on the Curved Field Lines for 30 keV Protons During Geomagnetic Storm as Inferred From Numerical Trajectory Tracing
Authors: Dubyagin S. , Apatenkov S. , Gordeev E. , Ganushkina N. , Zheng Y. 
Published: December 2020

AbstractThe rate of pitch angle scattering on the curved magnetic field lines is well parameterized by the ratio of the minimum field line curvature radius to the maximum effective particle gyroradius (K = RC/rg). The critical value of this ratio (Kcr) corresponding to the loss cone filling is of special interest since it corresponds to the low altitude isotropic boundaries (IBs). The early theoretical estimates gave Kcr = 8, whereas recent estimations of the K parameter on the field lines corresponding to the observed IBs during the geomagnetic storms revealed KIB values in the range of 3–30. We numerically trace the trajectories of the 30 keV protons in the magnetic field of the global magnetohydrodynamic simulation of the intense storm in order to infer statistical distribution of Kcr. The electric field and effects of nonstationarity are neglected in this study. It is found that although the Kcr values do show some variations during the course of the storm, its range is rather narrow 4 < Kcr < 8. The result suggests that higher KIB values found in the observational studies, if not caused by the magnetosphere‐ionosphere mapping error, should be attributed to some other mechanism of pitch angle scattering. The Kcr values tend to be lower (4–6) during the main phase because the region of low K values approaches the Earth and the equatorial loss cone size becomes larger due to a larger equatorial magnetic field in the near‐earth region. The remaining variation of Kcr is explained by the presence of the guide component of the magnetic field.
LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis
Authors: Cai Haiping , Yu Yanjiao , Ni Xiangrong , Li Cong , Hu Yuanjun , Wang Jing , Chen Furong , Xi Shaoyan , Chen Zhongping 
Published: December 2020

AbstractLong noncoding RNAs (lncRNAs), once considered to be nonfunctional relics of evolution, are emerging as essential genes in tumor progression. However, the function and underlying mechanisms of lncRNAs in glioma remain unclear. This study aimed to investigate the role of LINC00998 in glioma progression. Through screening using TCGA database, we found that LINC00998 was downregulated in glioblastoma tissues and that low expression of LINC00998 was associated with poor prognosis. Overexpression of LINC00998 inhibited glioma cell proliferation in vitro and in vivo and blocked the G1/S cell cycle transition, which exerted a tumor-suppressive effect on glioma progression. Mechanistically, RNA pull-down and mass spectrometry results showed an interaction between LINC00998 and CBX3. IP assays demonstrated that LINC00998 could stabilize CBX3 and prevent its ubiquitination degradation. GSEA indicated that LINC00998 could regulate the c-Met/Akt/mTOR signaling pathway, which was further confirmed by a rescue assay using siRNA-mediated knockdown of CBX3 and the Akt inhibitor MK2206. In addition, dual-luciferase assays showed that miR-34c-5p could directly bind to LINC00998 and downregulate its expression. Our results identified LINC00998 as a novel tumor suppressor in glioma, and LINC00998 could be a novel prognostic biomarker, providing a strategy for precision therapy in glioma patients.
High-resolution population-specific recombination rates and their effect on phasing and genotype imputation
Authors: Hassan Shabbeer , Surakka Ida , Taskinen Marja-Riitta , Salomaa Veikko , Palotie Aarno , Wessman Maija , Tukiainen Taru , Pirinen Matti , Palta Priit , Ripatti Samuli 
Published: November 2020

AbstractPrevious research has shown that using population-specific reference panels has a significant effect on downstream population genomic analyses like haplotype phasing, genotype imputation, and association, especially in the context of population isolates. Here, we developed a high-resolution recombination rate mapping at 10 and 50 kb scale using high-coverage (20–30×) whole-genome sequenced data of 55 family trios from Finland and compared it to recombination rates of non-Finnish Europeans (NFE). We tested the downstream effects of the population-specific recombination rates in statistical phasing and genotype imputation in Finns as compared to the same analyses performed by using the NFE-based recombination rates. We found that Finnish recombination rates have a moderately high correlation (Spearman’s ρ = 0.67–0.79) with NFE, although on average (across all autosomal chromosomes), Finnish rates (2.268 ± 0.4209 cM/Mb) are 12–14% lower than NFE (2.641 ± 0.5032 cM/Mb). Finnish recombination map was found to have no significant effect in haplotype phasing accuracy (switch error rates ~2%) and average imputation concordance rates (97–98% for common, 92–96% for low frequency and 78–90% for rare variants). Our results suggest that haplotype phasing and genotype imputation mostly depend on population-specific contexts like appropriate reference panels and their sample size, but not on population-specific recombination maps. Even though recombination rate estimates had some differences between the Finnish and NFE populations, haplotyping and imputation had not been noticeably affected by the recombination map used. Therefore, the currently available HapMap recombination maps seem robust for population-specific phasing and imputation pipelines, even in the context of relatively isolated populations like Finland.