bluuebunny/crossref_metadata_2025_split huggingface dataset:
The serratus anterior plane block for analgesia after thoracic surgery
Authors: Liu Xiancun , Song Tingting , Xu Hai-Yang , Chen Xuejiao , Yin Pengfei , Zhang Jingjing 
Published: May 2020

Abstract

Background:
The serratus anterior plane (SAP) block is a newer method that can be used in patients undergoing thoracic surgeries. The postoperative analgesia efficacy of SAP blocks for thoracic surgery remains controversial. We conduct a meta-analysis to evaluate the analgesia of SAP blocks after thoracic surgery.

Methods:
We searched PubMed, Embase, EBSCO, the Cochrane Library, Web of Science, and CNKI for randomized controlled trials (RCTs) regarding the postoperative pain control of a SAP block on thoracic surgery. All of the dates were screened and evaluated by two researchers and meta-analysis was performed using RevMan5.3 software.

Results:
A total of 8 RCTs involving 542 patients were included. The meta-analysis showed statistically significant differences between the two groups with respect to postoperative pain scores at 2 h (standardized mean difference [Std.MD] = −1.26; 95% confidence interval [CI] = −1.66 to −0.86; P < .0001); 6 h (SMD = −0.50; 95%CI = −0.88 to −0.11; P = .01); 12 h (SMD = −0.63; 95%CI = −1.10 to −0.16; P = .009); 24 h (SMD = −0.99; 95%CI = −1.44 to −0.51; P < .0001); postoperative opioid consumption at 24 h (SMD = −0.83; 95%CI = −1.10 to −0.56; P < .00001); and postoperative nausea and vomiting (PONV) rates (RR = 0.39; 95% CI = 0.21–0.73; P = .003).

Conclusion:
The SAP block can play an important role in the management of pain after thoracic surgery by reducing both pain scores and 24-h postoperative opioids consumption. In addition, there is fewer incidence of PONV in the SAP block group.
Down-regulation of EDN1 gene expression by circulating miR-206 is associated with risk of preeclampsia
Authors: Sheng Chunzhi , Zhao Yangchun , Zhu Libo 
Published: May 2020

Abstract
To study the correlation between circulating microRNA-206 (miR-206) levels and endothelin-1 (ET-1) levels, and to explore its association with preeclampsia (PE) risk.
Reverse transcription-PCR (RT-PCT) was used to compare the plasma miR-206 levels in 200 PE patients and 200 healthy controls. The correlation between miR-206 and ET-1 levels in plasma of PE patients was analyzed by Pearson analysis. MiR-206 was transfected into human umbilical vein endothelial cells cells and ET-1 expression was analyzed by enzyme-linked immunosorbent assay.
RT-PCR results showed that plasma miR-206 levels in PE patients were significantly higher than those in the control group (P < .01). The results of receiver operating characteristic curve analysis showed that the area under the curve of plasma miR-206 level in the diagnosis of PE was 0.94 (95% confidence interval: 0.92–0.96). Plasma ET-1 levels in PE patients were significantly lower than those in the control group by enzyme-linked immunosorbent assay (P < .01). The area under the curve of plasma ET-1 level in the diagnosis of PE was 0.92 (95% confidence interval: 0.90–0.95). The level of miR-206 in plasma was negative correlated with ET-1 level (r = -0.37, P < .01). The expression level of ET-1 was significantly decreased in human umbilical vein endothelial cells cells transfected with miR-206.
miR-206 can down-regulate the expression of EDN1 gene, which may be related to the increased risk of preeclampsia.
Efficacy of extracorporeal shock wave combined spinal core decompression for the treatment of patients with femoral head necrosis
Authors: Qiao Xiao-feng , Liu Shi-chen , Xue Yu , Ji Qing-hui 
Published: May 2020

Abstract

Background:
Previous studies have reported that extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) has been used for the treatment of patients with femoral head necrosis (FHN) effectively. However, their results are still inconsistent. Therefore, this study will systematically assess the efficacy and safety of EPSW and SCD for the treatment of patients with FHN.

Methods:
This study will systematically search the following databases from inception through March 1, 2020: MEDLINE, Web of Science, Scopus, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, and China National Knowledge Infrastructure. All searches will be performed without language and publication date restrictions. This study will only include randomized controlled trials investigating the efficacy and safety of EPSW and SCD for the treatment of patients with FHN. Two authors will independently assess all literatures, extract data, and appraise risk of bias. Any confusion between 2 authors will be cleared up by a third author through discussion. RevMan 5.3 software will be utilized to analyze the data and to perform a meta-analysis if necessary.

Results:
This study will summarize up-to-date evidence and provide a detailed summary related to the efficacy and safety of EPSW and SCD for the treatment of patients with FHN.

Conclusion:
This study may provide helpful evidence to determine whether or not EPSW combined SCD is effective and safety for the treatment of patients with FHN.

Systematic review registration:
INPLASY202040092.
Development and validation of 9-long Non-coding RNA signature to predicting survival in hepatocellular carcinoma
Authors: Deng Benyuan , Yang Min , Wang Ming , Liu Zhongwu 
Published: May 2020

Abstract
Primary hepatic carcinoma is 1 of the most common malignant tumors globally, of which hepatocellular carcinoma (HCC) accounts for 85% to 90%. Due to the high degree of deterioration and low early detection rate of HCC, most patients are diagnosed when they are already in the middle and advanced stages, and the prognosis are always poor.
RNA sequencing data from the cancer genome atlas was used to explore differences in lncRNA expression profiles. LncRNA was extracted by gdcRNAtools in R package. Multivariate cox analysis was performed on the screened lncRNAs. The relationship between the lncRNA model and prognosis as well as clinical characteristics of patients with HCC was analyzed. Finally, a predictive nomogram in the the cancer genome atlas cohort was established and verified internally
Based on the RNA sequencing survival analysis, a 9- lncRNAs prognosis model, including TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116 was established. The 9-lncRNA prognosis model was a reliable tool for predicting prognosis of HCC, and the nomogram of this prognosis model could help clinicians to choose personalized treatment for HCC patients
This model was significant to complement clinic characteristics of HCC and to promote personalized management of patients, it also provided a new idea for researches on the prognosis of HCC.
Effects of mild hypothermia on serum HMGB1 of brain-dead donors and its impact on kidney transplantation recipients
Authors: Shan Hui , Zhang Xin , Lin Zhe-Min , Wang Xue-Zhu , Mi Zi-Xin , Wang Ya-Ping , Tang Zi-Ren , Zhang Xiao-Dong 
Published: May 2020

Abstract
Investigate the effect of mild hypothermia on serum inflammatory factor HMGB1 of brain-dead donors, and its significance for renal transplantation recipients.
In our hospital between January 2018 and January 2019 up to the standard of brain death donor (aged 18 to 65 years old) prospective cohort study, brain death donor were randomly divided into mild hypothermia group and the non-mild hypothermia group. Serum were collected from donor at different periods, and enzyme-linked immunoassay (ELISA) was used to determine the serum HMGB1 concentration to compare the difference between the 2 donor groups. The early recovery of renal function after renal transplantation was followed up, and the incidence of delayed graft function (DGF) and early recovery of renal function were compared between the 2 groups. The correlation between donor HMGB1 and recipient DGF was analyzed.
Between 17 donors in the mild hypothermia group and 17 in the non-mild hypothermia group, there were no statistically significant differences in the age, perioperative urine volume and ICU stay between the 2 groups. After mild hypothermia treatment, serum HMGB1 levels of brain death donors were significantly decreased. While in non-mild hypothermia brain death donor group without treatment, serum HMGB1 was significantly increased. There were no statistically significant differences in age and preoperative creatinine between the 2 recipient groups, including 33 patients in the mild hypothermia group and 34 patients in the non-mild hypothermia group. DGF incidence was lower in mild hypothermia group comparing with non-mild hypothermia group with statistical significance. The levels of HMGB1 from donor before procurement is correlated with the occurrence of DGF of the recipient.
Mild hypothermia therapy can reduce the levels of serum HMGB1, improve the function of donor organs. The levels of HMGB1 before donor procurement can be used to predict the occurrence of DGF in kidney transplant recipients. Our study shows that HMGB1 can be potentially used as therapeutic target of early intervention for brain death donors. Furthermore, mild hypothermia therapy can be applied in the maintenance of brain death donors for kidney transplant recipient to improve the successful rate of transplantation.
Tracheobronchial foreign body aspiration in children
Authors: Ding Guodong , Wu Beirong , Vinturache Angela , Cai Chen , Lu Min , Gu Haoxiang 
Published: May 2020

Abstract
Foreign body (FB) aspiration is a common and serious problem in childhood as it requires early recognition and treatment to avoid potentially lethal consequences. This study aimed to characterize the clinical and epidemiological features of airway FBs in a pediatric Chinese population.
A retrospective review of medical records of children aged 0 to 14 years who attended with a diagnosis of FB aspiration the Shanghai Children's Hospital between January 2013 and December 2017 was carried out. Descriptive analysis was used to assess patient's demographics, clinical, radiographic, bronchoscopic findings, time to presentation, and characteristics of the FBs.
Among the 200 patients included in the study, 92% were under 3 years of age, with a peak incidence of FB aspiration occurring between 1 and 2 years old. The male to female ratio was about 2.6:1. Twenty-three percent of the patients were admitted within 24 hours of the event, 40% within 1 week, 30% within 1 month, and 7% more than 1 month after aspiration. The most common presenting symptoms of laryngotracheal FBs were cough, dyspnea, and wheezing; those of bronchial FBs were cough, decreased air entry, and wheezing. Chest X-ray was normal in four-fifths of the children with laryngotracheal FBs, whereas most common abnormal X-ray findings in children with bronchial FBs were mediastinal shift, obstructive emphysema, and pneumonia. There was a trend that in children younger than 2 years FBs were more frequently found in the left bronchus, whereas in older children FBs were more frequently found in the right bronchus. Ninety-three percent of the removed FBs were organic materials such as food items and the most frequently aspirated FBs were peanuts. Flexible bronchoscopy was performed in 82.5% of the patients, while rigid bronchoscopy or direct laryngoscopy in 17.5% of the patients. Four patients were subjected to thoracic surgery and 1 died during rigid bronchoscopy due to acute respiratory failure.
FBs is a frequent pathology among Chinese children. Tracheobronchial FBs should be strongly suspected in young children who have sudden onset of cough and wheezing episode, even when physical and radiographic evidence is absent.
Chronic pain and spinal cord stimulation
Authors: Corallo Francesco , De Salvo Simona , Cannistraci Cecilia , Lo Buono Viviana , Di Cara Marcella , Floridia Daniela , Cerra Francesco , Romeo Laura , Pria Deborah , Bramanti Placido , Marino Silvia , Bonanno Lilla 
Published: May 2020

Abstract
Chronic pain can have a devastating impact and lead to patient isolation. Many people with chronic pain are predisposed to anxiety-depressant symptoms, due to a lower quality life. The aim of the study is to demonstrate how neuromodulation methods, can encourage the reduction of chronic pain and an improvement in the quality of life, therefore advancing the restoration of psychological well-being.
We involved 50 patients with a diagnosis of pain that not respond to traditional pharmacological therapies. Interventions: All subject had depression and anxiety symptoms and a low-quality life. We used the spinal cord stimulation treatment and a psychological evaluation for assessment of depression-anxiety symptomatology and the level of quality life.
We observed a significant difference in physical functioning, role limitations due to physical health, general health perceptions, vitality, social functioning, role limitations due to emotional problems and mental health.
Our study affirms that the perception of chronic pain has a great impact on the perception of psychological well-being, quality of life, and the performance of normal daily social and professional activities.
Clonality and inbreeding amplifies genetic isolation and mate limitation in a rare montane woody plant (Persoonia hindii; Proteaceae)
Authors: Ahrens Collin , Tierney David , Rymer Paul D. 
Published: May 2020

AbstractSmall populations have genetic attributes that make them prone to extinction, including low effective population size (Ne), increased levels of inbreeding, and negative impacts from genetic drift. Some small populations are also clonal with low levels of genetic diversity, restricted seed dispersal, and high levels of genetic structure. Together, these attributes make species with small, isolated, clonal populations unlikely to persist under environmental change. We investigated an endangered woody plant species (Persoonia hindii) in eastern Australia to answer key questions about genetic differentiation, migration rates, population sizes, size of clones, mating system andNe. We identified 587 single nucleotide polymorphisms. Of the 88 individual stems collected from 15 sites across the entire distribution ofP. hindii, we identified 30 multi-locus genotypes (MLG). Additional fine-scale genotyping of two sites (49 and 47 stems) detected a dominant genet within each site occupying a minimum area of 20 m2. Global population differentiation was high (FST0.22) with very low migration rates (0.048 - 0.064). We identified some population structure with variable site pairwise differentiation (0.015 - 0.32) with no detectable spatial autocorrelation. Species wide inbreeding coefficient was 0.42 (FIT), supporting the direct estimate of 82% selfing. EstimatedNewas extremely small (15), indicating that genetic drift may be reducing genetic diversity and increasing genetic load through fixation of deleterious alleles. Clonality and inbreeding combined with negligible gene flow suggests limited adaptive capacity to respond to climate challenges. Genetic rescue, through assisted gene migration and experimental translocations, would enhance the persistence of natural populations.
Freshwater diatom biomonitoring through benthic kick-net metabarcoding
Authors: Maitland Victoria Carley , Robinson Chloe Victoria , Porter Teresita M. , Hajibabaei Mehrdad 
Published: May 2020

AbstractBiomonitoring is an essential tool for assessing ecological conditions and informing management strategies. The application of DNA metabarcoding and high throughput sequencing has improved data quantity and resolution for biomonitoring of taxa such as macroinvertebrates, yet, there remains the need to optimise these methods for other taxonomic groups. Diatoms have a longstanding history in freshwater biomonitoring as bioindicators of water quality status. However, periphyton scraping, a common diatom sampling practice, is time-consuming and thus costly in terms of labour. This study examined whether the benthic kick-net technique used for macroinvertebrate biomonitoring could be applied to bulk-sample diatoms for metabarcoding. To test this approach, we collected samples using both conventional microhabitat periphyton scraping and bulk-tissue kick-net methodologies in parallel from replicated sites with different habitat status (good/fair). We found there was no significant difference in community assemblages between conventional periphyton scraping and kick-net methodologies, but there was significant difference between diatom communities depending on site quality (P = 0.029). These results show the diatom taxonomic coverage achieved through DNA metabarcoding of kick-net is suitable for ecological biomonitoring applications. The shift to a more robust sampling approach and capturing diatoms and macroinvertebrates in a single sampling event has the potential to significantly improve efficiency of biomonitoring programmes.
Amnion signals are essential for mesoderm formation in primates
Authors: Yang Ran , Goedel Alexander , Kang Yu , Si Chenyang , Chu Chu , Zheng Yi , Chen Zhenzhen , Gruber Peter J. , Xiao Yao , Zhou Chikai , Witman Nevin , Leung Chuen-Yan , Chen Yongchang , Fu Jianping , Ji Weizhi , Lanner Fredrik , Niu Yuyu , Chien Kenneth 
Published: May 2020

AbstractEssential genes for murine embryonic development can demonstrate a disparate phenotype in human cohorts. By generating a transcriptional atlas containing >30,000 cells from postimplantation non-human primate embryos, we discovered thatISL1, a gene with a well-established role in cardiogenesis, controls a gene regulatory network in primate amnion. CRISPR/Cas9-targeting ofISL1resulted in non-human primate embryos which did not yield viable offspring, demonstrating thatISL1is critically required in primate embryogenesis. On a cellular level, mutantISL1embryos displayed a failure in mesoderm formation due to reduced BMP4 signaling from the amnion. Via loss of function and rescue studies in human embryonic stem cells we confirmed a similar role ofISL1in humanin vitroderived amnion. This study highlights the importance of the amnion as a signaling center during primate mesoderm formation and demonstrates the potential ofin vitroprimate model systems to dissect the genetics of early human embryonic development.
Assessment on aerodynamic degradation for wing-damaged transport aircraft
Authors: Ding Menglong , Zeng Chuan , Binienda Wieslaw K. 
Published: May 2020

Purpose
Wingtip loss is an existing type of transport aircraft hazard which is a real threat to flight safety caused by a missile strike, underwing engine explosion or impact with obstructions when performing near-ground operations. The primary effect of the wingtip loss is an asymmetric rolling moment, which may result in the fatal loss of control for the aircraft. This study aims to assess whether aerodynamic degradation will cause a wing-damaged transport aircraft to lose its balance under a certain level of wing damage and if a pilot can compensate for the loss of aerodynamic force and regain the balance of the aircraft.

Design/methodology/approach
In this paper, experimental and numerical studies were conducted to investigate the aerodynamic characteristics of a wingtip-lost transport aircraft in landing configuration. Various levels of wing damages including wingtip, slat and flap loss were considered. The numerical simulations were performed with ANSYS Fluent. The computational fluid dynamics calculation was validated by wind tunnel tests.

Findings
The aerodynamic performance of the aircraft with wing-damaged condition was presented. It was revealed that the wingtip loss leads to an asymmetric rolling moment and a reduction of the lift force, which affects the balance of the transport aircraft. The methods to compensate for the lift force and the asymmetric rolling moment were investigated for a safe landing. The lateral balance cannot be maintained in cases with serious damage on the wing (larger than 53% of the semi-span) or moderate damage on the wing with loss of slats and flaps.

Originality/value
The nonlinear results indicate the importance of aerodynamic assessment for the sake of training pilots to properly handle the hazard situation and explore the critical facts leading to the air crash.
CSR Disclosure, Corporate Governance and Firm Value: a study on GCC Islamic Banks
Authors: Harun Mohd Shukor , Hussainey Khaled , Mohd Kharuddin Khairul Ayuni , Farooque Omar Al 
Published: May 2020

PurposeThis study aims to explore the corporate social responsibility disclosure (CSRD) practices of the Islamic banks in the Gulf Cooperation Council (GCC) countries during the period 2010-2014 and examines the determinants of CSRD and its effects on firm value.Design/methodology/approachBased on the Accounting and Auditing Organization for Islamic Financial Institutions Governance Standard No. 7 guidelines and using content analysis, the paper develops a comprehensive CSRD index for GCC Islamic banks. The study applies ordinary least squares regression analysis for hypothesis testing and for finding determinants of respective dependent variables.FindingsThe results show a very low level of CSRD among the sample Islamic banks in GCC countries. When using corporate governance characteristics to examine the determinants of CSRD, this study provides evidence of a significant positive association between board size and CSRD practice in Islamic banks and a significant negative relationship of chief executive officer (CEO) duality with CSRD, as per expectation. For the economic consequences of CSRD, the study documents an inverse performance effect of CSRD while board size, board composition and CEO duality indicate significant positive effects on firm value.Research limitations/implicationsThe relatively small sample size of GCC Islamic banks may limit the application of the findings to other Islamic financial institutions such as Takaful and the Islamic unit trust company.Practical implicationsThe findings of this study initiate the global debate on the need for corporate governance reform in Islamic banks by providing insights on the role played by corporate governance mechanisms in encouraging and enhancing CSRD practices among Islamic banks. The findings also have important implications for investors, managers, regulatory bodies, policymakers and Islamic banks in the GCC countries.Social implicationsThe results of the study do not support the idea that Islamic banks operating on Islamic principles can meet their social responsibilities through promoting corporate social responsibility (CSR) activities and by differentiating themselves from non-Islamic banks.Originality/valueThis is the first study to examine the determinants of CSRD in GCC Islamic banks using comprehensive CSRD and corporate governance variables and, therefore, adds value to the existing CSR literature in banking.