bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galectin-1 is associated with the severity of coronary artery disease and adverse cardiovascular events in patients undergoing coronary angiography
Authors: Chou Ruey-Hsing , Huang Shao-Sung , Kuo Chin-Sung , Wang Shen-Chih , Tsai Yi-Lin , Lu Ya-Wen , Chang Chun-Chin , Huang Po-Hsun , Lin Shing-Jong 
Published: November 2020

AbstractGalectin-1, a β-galactoside-binding lectin mediating inflammation and neovascularization, is reported to attenuate ventricular remodeling after myocardial infarction. But its role in stable coronary artery disease (CAD) has not been fully elucidated. This study aimed to identify the relationship between the circulating galectin-1 level and the severity of CAD in patients with suspected CAD. Pre-procedure galectin-1 and high-sensitivity C-reactive protein (hs-CRP) concentrations were measured in 834 subjects who underwent scheduled coronary angiography. Subjects were grouped into tertiles of the galectin-1 levels. SYNTAX scores were calculated to evaluate the severity of CAD. All patients were followed until January 2019 or the occurrence of major adverse cardiovascular events (MACE). Patients with higher galectin-1 concentrations were older; had greater prevalence of hypertension, diabetes, chronic kidney disease, and heart failure; and were more likely to present with higher hs-CRP levels and SYNTAX scores. During the follow-up period of 1.3 ± 1.1 years, patients in the highest tertile of galectin-1 were associated with a greater risk of MACE after adjustment for age, sex, comorbidities, co-medications, serum levels of hemoglobin, creatinine, hs-CRP, ejection fraction, SYNTAX scores, and revascularization modalities (adjusted hazard ratio 10.95, 95% confidence interval 2.29–52.47, p = 0.003). Galectin-1 showed better discriminatory performance than hs-CRP, and non-inferior performance to SYNTAX scores, in predicting the incidence of MACE.
HbWRKY27, a group IIe WRKY transcription factor, positively regulates HbFPS1 expression in Hevea brasiliensis
Authors: Qu Long , Li Hui-Liang , Guo Dong , Wang Ying , Zhu Jia-Hong , Yin Li-Yan , Peng Shi-Qing 
Published: November 2020

AbstractFarnesyl pyrophosphate synthase (FPS) is a key enzyme that catalyzes the formation of farnesyl pyrophosphate, the main initiator for rubber chain initiationin Hevea brasiliensisMuell. Arg. The transcriptional regulatory mechanisms of the FPS gene still not well understood. Here, a WRKY transcription factor designated HbWRKY27 was obtained by screening the latex cDNA library applied theHbFPS1promoter as bait. HbWRKY27 interacted with theHbFPS1promoter was further identified by individual Y1H and EMSA assays. HbWRKY27 belongs to group IIe WRKY subfamily which contains a typical WRKY domain and C-X5-CX23-HXH motif. HbWRKY27 was localized to the nucleus.HbWRKY27predominantly accumulated in latex.HbWRKY27was up-regulated in latex by ethrel, salicylic acid, abscisic acid, and methyl jasmonate treatment. Transient expression of HbWRKY27 led to increasing the activity of theHbFPS1promoter in tobacco plant, suggesting that HbWRKY27 positively regulates theHbFPS1expression. Taken together, an upstream transcription factor of the key natural rubber biosynthesis geneHbFPS1was identified and this study will provide novel transcriptional regulatory mechanisms of the FPS gene inHevea brasiliensis.
The effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive–compulsive disorder
Authors: Kim Minah , Jung Wi Hoon , Shim Geumsook , Kwon Jun Soo 
Published: November 2020

AbstractWhether brain network connectivity during goal-directed planning in patients with obsessive–compulsive disorder (OCD) is abnormal and restored by treatment with selective serotonin reuptake inhibitors (SSRIs) remains unknown. This study investigated whether the disrupted network connectivity during the Tower of London (ToL) planning task in medication-free OCD patients could be restored by SSRI treatment. Seventeen medication-free OCD patients and 21 matched healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) while performing the ToL task at baseline and again after 16 weeks of SSRI treatment. Internetwork connectivity was compared across the groups and treatment statuses (pretreatment versus posttreatment). At baseline, compared with the HCs, the OCD patients showed lower internetwork connectivity between the dorsal attention network and the default-mode network during the ToL planning task. After 16 weeks of SSRI treatment, the OCD patients showed improved clinical symptoms accompanied by normalized network connectivity, although their improved behavioral performance in the ToL task did not reach that of the HCs. Our findings support the conceptualization of OCD as a network disease characterized by an imbalance between brain networks during goal-directed planning and suggest that internetwork connectivity may serve as an early biomarker of the effects of SSRIs on goal-directed planning.
Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling
Authors: Hasebe Takashi , Fujimoto Kenta , Ishizuya-Oka Atsuko 
Published: November 2020

AbstractIn the Xenopus laevis intestine during metamorphosis, stem cells appear and generate the adult epithelium analogous to the mammalian one. We have previously shown that connective tissue cells surrounding the epithelium are essential for the stem cell development. To clarify whether such cells correspond to mammalian Foxl1-expressing mesenchymal cells, which have recently been shown to be a critical component of intestinal stem cell niche, we here examined the expression profile of Foxl1 in the X. laevis intestine by using RT-PCR and immunohistochemistry. Foxl1 expression was transiently upregulated only in connective tissue cells during the early period of metamorphic climax and was the highest just beneath the proliferating stem/progenitor cells. In addition, electron microscopic analysis showed that these subepithelial cells are ultrastructurally identified as telocytes like the mammalian Foxl1-expressing cells. Furthermore, we experimentally showed that Foxl1 expression is indirectly upregulated by thyroid hormone (TH) through Shh signaling and that TH organ-autonomously induces the Foxl1-expressing cells concomitantly with appearance of the stem cells in the tadpole intestine in vitro. The present results suggest that intestinal niche cells expressing Foxl1 are evolutionally conserved among terrestrial vertebrates and can be induced by TH/Shh signaling during amphibian metamorphosis for stem cell development.
Drought analysis with different indices for the Asi Basin (Turkey)
Authors: Dikici Mehmet 
Published: November 2020

AbstractToday, within the scope of planning, development and management of water resources affected adversely by climate change, the issue of minimization of the adverse effects of drought has become very important. In this study, drought risk analyses were performed using meteorological, hydrogeological and hydrological data of the Asi basin and as a result of the determination of different indices and indicators available in the literature. First, the missing data was completed by regional analyses. The DI (Deciles Index), SPI (Standardized Precipitation Index), SPEI (Standardized Precipitation Evapotranspiration Index) and SRI (Standardized Runoff Index) indices were described. Drought severity and magnitude were found according to these indices. Based on 1, 3, 6, 9, 12, 48-month recurrence intervals, analyses were made. Classification of droughts and their threshold values were determined. For some places, drought incidence rates were presented according to each index. The indices were compared, the correlation between them was examined and a common conclusion was reached. The drought severities, which has a precipitation area of 7800 m2, were evaluated for certain recurrence intervals. For this purpose, based on meteorological, hydrological and hydrogeological data for the years between 1970 and 2016, DI, SPI, SPEI, and SRI indices were analyzed and compared.
Correlation Between Traumatic Skin and Subcutaneous Injuries and the Severity of Polytrauma Injury
Authors: Klempka Anna , Fischer Christian , Kauczor Hans-Ulrich , Weber Marc-André 
Published: November 2020

Purpose To examine the relationship between superficial lesions (such as bruises, hematomas, deep abrasions, and soft tissue emphysema) and internal post-traumatic injuries, assessed using whole-body computed tomography (WBCT), and to determine if these are valid markers for internal injuries.
Methods and Materials 250 patients who underwent WBCT emergency scans for suspected polytrauma were retrospectively analyzed after institutional review board approval of the study. The scans were carried out on patients who met the criteria for standard operating procedures for WBCT emergency scans. WBCT covering the entire head, neck, chest, and abdomen (including pelvis and proximal lower extremities) and at least one phase with intravenous contrast agent were included in the study. Initial analyses of immediate WBCT scans was carried out by a consultant radiologist and a radiological resident. The first reading focused on internal damage that needed immediate therapy. The second reading focused on a detailed analysis of the skin and subcutaneous tissue and their relation to internal injuries without the time pressure of an emergency setting, carried out by another experienced radiologist. All skin lesions and the degree of penetration and a comparison between the two readings were reported in tables.
Results Superficial lesion of the chest was detected in 19 patients, 17 of them had an internal injury of the thorax while only two patients, with hematoma of the chest wall, had no internal injuries. Skin and subcutaneous lesions of the chest had the strongest association with an internal injury. Skin lesions of the abdominal wall were observed in 30 patients. In only 11 cases, these lesions were correlated with internal injuries, such as fractures or active bleeding. 52 skin and subgaleal lesions of the scalp were observed. In 20 of these patients, an intracranial or internal injury was detected. In 3 patients, skin abrasions of the neck were present and in only one of them, this finding was associated with an internal injury.
Conclusion Trauma patients whose history and clinical presentation meet the standard operating procedures for WBCT emergency scans and who present with a cutaneous lesion, especially at the neurocranium or chest wall, should be observed for internal injuries by WBCT.
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Development of a Patient-Oriented Organizational Management System for Intravitreal Injection Therapy in a Standardized “Treat-and-Extend” Regime at a University Eye Clinic
Authors: Framme Carsten , Greb Oliver , Bayer Sascha , Buley Pascal , Pielen Amelie , Hufendiek Katerina , Junker Bernd , Volkmann Ingo 
Published: November 2020

Abstract
Background The treatment of macular edema with intravitreal injections has revolutionized the treatment of associated diseases in ophthalmology. However, with a few exceptions, this is a chronic treatment where patients require many injections and usually need to stay in treatment for years. Patient adherence and control of patient flow are critical to treatment success. In this manuscript, we describe the development of a patient-oriented organization management for intravitreal injections in a university hospital.
Material and Methods In 2015, the intravitreal treatment in our clinic was switched to the treat-and-extend regime. At the same time, the optimization of the previous organizational processes in perioperative management was evaluated. For the period 2015 to 2018, we analyzed and gradually optimized the procedures of our intravitreal injection therapy in a survey with a specialized service provider.
Results Through the analysis of the original processes, the patient appointment was optimized, work processes were summarized, spatially reorganized and there was only a slight increase in the number of staff involved compared with the significant increase in the number of injections. Through these measures, the total in-hospital-time of the patients could be drastically reduced and at the same time the number of patients on one operation day could be multiplied.
Conclusion In the context of chronic treatment with intravitreal injections, the care of an increased number of patients is a logistical challenge. By optimizing processes, existing resources can be better used to meet the increased demands. An optimized system offers the patient greater adherence and a better visual outcome largely independent of the medication used.
Gold Catalysis of Non-Conjugated Haloacetylenes
Authors: Haberhauer Gebhard , Siera Hannah , Semleit Nina , Kreuzahler Mathis , Wölper Christoph 
Published: November 2020

AbstractGold-catalyzed reactions of conjugated haloacetylenes are well known and usually result in the formation of addition or dimerization products. Herein, we report a gold-catalyzed reaction of non-conjugated­ haloacetylenes, which leads exclusively to the halogenated cyclization products. Remarkable is the gold-catalyzed reaction of tritylhaloacetylenes to haloindene derivatives, as mechanistic studies reveal that an 1,2-aryl shift occurs in the initially formed gold complex. The potential functionalization at the halogen atom and the wide scope of these cyclization reactions make them an attractive method for the construction of cyclic systems.
No dejemos morir al hueso: interiorizándonos con los procesos óseos avasculares
Authors: Mena Karen , Mendoza Margareth , Galván Juan Manuel , Jeanmaire Esteban , Ferrari Luciana , Cobeñas Ricardo 
Published: November 2020

ResumenEl objetivo de este artículo es realizar una revisión de las localizaciones, causas y hallazgos radiológicos específicos de los procesos avasculares óseos.Se define como isquemia ósea a las alteraciones ocasionadas por déficit de irrigación, llevando a la destrucción del hueso. Existen diferencias entre necrosis isquémica e infarto óseo, en base al sitio óseo de afectación. La etiología traumática es la más frecuente y suele ser unilateral. Los sitios de presentación más frecuentes son: cabeza femoral y humeral, rodilla y semilunar.La resonancia magnética (RM) es considerada la modalidad de imagen más sensible y específica, tanto para el diagnóstico temprano como estadificación y control.El conocimiento de las causas, características radiológicas y sus diferentes fases evitan el diagnóstico erróneo de otras etiologías, como las primarias o infecciosas, facilitando un correcto algoritmo terapéutico.
Extended Anterolateral Infralabyrinthine Transjugular Approach for Microsurgical Resection of Giant Glomus Vagale Tumor: Operative Video and Technical Nuances
Authors: Liu James K. , Zhao Kevin , Baredes Soly , Jyung Robert W. 
Published: November 2020

AbstractGlomus vagale tumor is a paraganglioma of the vagus nerve. It is a rare type of benign tumor that occupies the head and neck and skull base regions. Patients often present with lower cranial nerve dysfunctions such as difficulty swallowing, tongue weakness, and hoarseness. Surgical treatment can be complex and difficult due to its high vascularity, frequent involvement of lower cranial nerves, and surrounding critical vascular structures. In this operative video, we demonstrate an extended anterolateral infralabyrinthine transjugular approach for microsurgical resection of a giant glomus vagale tumor in a 53-year-old male who presented with an enlarging neck mass, difficulty swallowing, right tongue weakness, and hoarseness. Imaging revealed a giant glomus vagale tumor in the right parapharyngeal space extending into the jugular foramen with occlusion of the internal jugular vein. After preoperative embolization, the patient underwent a near-total resection of the tumor with a small microscopic residual at the pars nervosa. In summary, the extended anterolateral infralabyrinthine transjugular approach is a useful strategy for removal of giant glomus vagale tumors extending into the skull base. The surgical technique and nuances are described in a step-by-step fashion in this illustrative operative video.The link to the video can be found at: https://youtu.be/L0EosQK95LE.
Short-Term Effects of Isometric Quadriceps Muscle Exercise with Auditory and Visual Feedback on Pain, Physical Function, and Performance after Total Knee Arthroplasty: A Randomized Controlled Trial
Authors: Kondo Yasutaka , Yoshida Yoshihiro , Iioka Takashi , Kataoka Hideki , Sakamoto Junya , Hirase Tatsuya , Honda Yuichiro , Nawata Atsushi , Okita Minoru 
Published: November 2020

AbstractSevere acute pain after total knee arthroplasty (TKA) may cause delay in muscle strength and functional recovery, and it is a risk factor for chronic postoperative pain. Although pharmacological approaches are the typical firstline to treat acute pain; recently, nonpharmacological approaches such as exercise have been increasingly applied. The purpose of this investigation was to evaluate the effects of a rehabilitation program involving isometric quadriceps exercise with auditory and visual feedback to improve the short-term outcome after TKA. Sixty-two patients, planning a primary unilateral TKA, were randomly assigned to either an intervention group (n = 31) involving isometric quadriceps exercise with auditory and visual feedback in usual rehabilitation after TKA or a control group (n = 31) involving a standardized program for TKA. Patients in the intervention group performed the isometric quadriceps muscle exercise using the Quadriceps Training Machine from 2 to 14 days after TKA instead of the traditional quadriceps sets. Pain intensity, isometric knee extension strength, range of motion, timed up and go test (TUG), 10-m gait speed, 6-minute walking distance, the Western Ontario and McMaster University Osteoarthritis index (WOMAC), the hospital anxiety and depression scale, and the pain catastrophizing scale were assessed before TKA (baseline) and 1 to 3 weeks after TKA. Pain intensity significantly decreased in the intervention group than in the control group at 1 (p = 0.005), 2 (p = 0.002), and 3 (p = 0.010) weeks after TKA. Greater improvements in TUG (p = 0.036), 10-m gait speed (p = 0.047), WOMAC total score (p = 0.017), pain (p = 0.010), and function (p = 0.028) 3 weeks after TKA were observed in the intervention group. These results suggest that isometric quadriceps exercises with auditory and visual feedback provided early knee pain relief, possibly leading to better improvements in physical performance, and patient's perception of physical function in the early stages of postoperative TKA. Further studies should investigate whether this short-term effect is sustainable.
Treatment of Posterior Cruciate Ligament Tibial Avulsion: A New Modified Open Direct Lateral Posterior Approach
Authors: Keyhani Sohrab , Soleymanha Mehran , Salari Amir 
Published: November 2020

AbstractThe optimal operative technique for the treatment of the tibial-side avulsion injuries of the posterior cruciate ligament (PCL) is debatable. This study was aimed to evaluate the postoperative outcomes and complications if any after an open direct, posterolateral approach using cannulated cancellous screw fixation of a PCL tibial avulsion. From January 2016 to June 2018, 17 patients (14 males and 3 females) with PCL avulsion fraction treatment—who underwent open reduction and internal fixation using cannulated cancellous screws—were included in this prospective study. A direct posterolateral approach in the prone position was used in all cases. The Lysholm's knee score and International Knee Documentation Committee (IKDC) score were assessed preoperatively and during regular follow-up examinations for at least 1 year (12–20 months) postoperatively. All patients had fracture union and all of their knees were stable upon physical examination. No nerve or blood vessel injuries occurred. The mean Lysholm's scores and mean IKDC scores were improved significantly at the last follow-up. This study provides evidence that open direct posterolateral approach may be reliable for the treatment of tibial-sided bony PCL avulsion fractures. This approach can provide direct visualization of the posterior capsule and PCL avulsion site associated with good reduction and stable fixation, easy application of the screws directly from posterior to anteriorly without extensive soft tissue damage. Nevertheless, long-term follow-up is recommended.
Resonant gravitational waves in dynamical Chern–Simons–axion gravity
Authors: Fujita Tomohiro , Obata Ippei , Tanaka Takahiro , Yamada Kei 
Published: November 2020

Abstract
In this paper, we consider dynamical Chern–Simons gravity with the identification of the scalar field coupled though the Pontryagin density with the axion dark matter, and we discuss the effects of the parametric resonance on gravitational waves (GWs). When we consider GWs in a coherently oscillating axion cloud, we confirm that significant resonant amplification of GWs occurs in a narrow frequency band, and the amplification is restricted to the late epoch after the passage of the incident waves. We also identify the condition that an axion cloud spontaneously emits GWs. Once we take into account the randomness of the spatial phase distribution of the axion oscillations, we find that the amplification is suppressed compared with the coherent case, but significant amplification of GWs can still occur. We also examine whether or not the amplification of GWs is possible in the present Universe, taking into account the history of the Universe. We find that resonant amplification is difficult to be tested from GW observations in the standard scenario of the axion DM model, in which the axion is the dominant component of DM. However, there is some parameter window in which the resonant amplification of GWs might be observed, if the axion is subdominant component of DM, and the axion cloud formation is delayed until the Hubble rate becomes much smaller than the axion mass.
Experimental test of fair three-sided coins
Authors: Bosso Pasquale , Huber Anthony , Todorinov Vasil 
Published: November 2020

Abstract
A simple model for a fair ‘three-sided coin’ is proposed and tested. Describing the coin as a cylinder with a given height and basis radius, this model efficiently characterizes the problem, constraining the size of the coin. A statistical analysis of the data collected from actual realizations of such coins has been performed, supporting the proposed model. Besides studying the case of a fair three-sided coin, this work represents a model for an explicit application of the scientific method, in which all parts (problem characterization, statement of a hypothesis, experiment, analysis, description, conclusions) have clearly directed its development. Thus, it represents an useful illustration of such method for undergraduate students.
Broad-band photoluminescence of donor–acceptor pairs in tetrahedrite Cu10Cd2Sb4S13 microcrystals
Authors: Krustok Jüri , Raadik Taavi , Kaupmees Reelika , Ghisani Fairouz , Timmo Kristi , Altosaar Mare , Mikli Valdek , Grossberg Maarja 
Published: November 2020

Abstract
We present temperature and laser power dependent photoluminescence (PL) study of Cd substituted tetrahedrite Cu10Cd2Sb4S13 microcrystals. At T = 10 K a single broad, asymmetric and structureless PL band was detected at about 1.08 eV. The temperature and laser power dependencies indicate that the properties of PL emission can be explained by the distant donor–acceptor (DA) pair model, where a donor defect has a depth of E
D ≈ 30 meV and an acceptor defect E
A = 88 ± 6 meV. It was shown that the shape of the DA pair band could be effectively described using statistical distribution of donor–acceptor defects, recombination probability of DA pairs with different spatial separation, relatively strong electron–phonon coupling and occupation probabilities of donor and acceptor defects. At T = 200 K the DA pair recombination gradually starts to transform into conduction band-acceptor recombination.