bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice
Authors: Törnqvist Anna E. , Grahnemo Louise , Nilsson Karin H. , Funck-Brentano Thomas , Ohlsson Claes , Movérare-Skrtic Sofia 
Published: March 2020

AbstractEpidemiological studies have shown that high bone mineral density (BMD) is associated with an increased risk of osteoarthritis (OA), but the causality of this relationship remains unclear. Both bone mass and OA have been associated with the WNT signaling pathway in genetic studies, there is thus an interest in studying molecular partners of the WNT signaling pathway and OA. Female mice overexpressing WNT16 in osteoblasts (Obl-Wnt16 mice) have an increased bone mass. We aimed to evaluate if the high bone mass in Obl-Wnt16 mice leads to a more severe experimental OA development than in WT control mice. We induced experimental OA in female Obl-Wnt16 and WT control mice by destabilizing the medial meniscus (DMM). The Obl-Wnt16 mice displayed thicker medial and lateral subchondral bone plates as well as increased subchondral trabecular bone volume/tissue volume (BV/TV) but un-altered thickness of articular cartilage compared to WT mice. After DMM surgery, there was no difference in OA severity in the articular cartilage in the knee joint between the Obl-Wnt16 and WT mice. Both the Obl-Wnt16 and WT mice developed osteophytes in the DMM-operated tibia to a similar extent. We conclude that although the Obl-Wnt16 female mice have a high subchondral bone mass due to increased WNT signaling, they do not exhibit a more severe OA phenotype than their WT controls. This demonstrates that high bone mass does not result in an increased risk of OA per se.
Localization of claudin-2 and claudin-3 in eutopic and ectopic endometrium is highly similar
Authors: Hoerscher Alena , Horné Fabian , Dietze Raimund , Berkes Eniko , Oehmke Frank , Tinneberg Hans-Rudolf , Meinhold-Heerlein Ivo , Konrad Lutz 
Published: March 2020

Abstract
Purpose
Claudins as the major components of tight junctions are important in maintaining cell–cell integrity and thus function as a barrier. Dysregulation of the claudins is often associated with loss of the epithelial phenotype, a process called epithelial–mesenchymal transition (EMT), which most often results in gain of migrative and invasive properties. However, the role of claudins in the endometrium or endometriosis has only rarely been examined.

Methods
In this study, we investigated localization of claudin-2 and claudin-3 in the eutopic and ectopic endometrium with immunohistochemistry. A detailed quantification with HSCORE was performed for claudin-2 and claudin-3 in endometrium without endometriosis and in cases with endometriosis compared to the three endometriotic entities: peritoneal, ovarian, and deep-infiltrating endometriosis.

Results
We found a preferential localization of both claudins in the glandular and the luminal epithelial cells in the endometrium with and without endometriosis. Quantification of localization of both claudins showed no differences in eutopic endometrium of control cases compared to cases with endometriosis. Furthermore, both claudins are localized highly similar in the ectopic compared to the eutopic endometrium, which is in clear contrast to previously published data for claudin-3.

Conclusion
From our results, we conclude that localization of claudin-2 and claudin-3 is highly stable in eutopic and ectopic endometrium without any loss of the epithelial phenotype and thus do not contribute to the pathogenesis of endometriosis.
Outcomes for a clinically representative cohort of hearing-impaired adults using the Nucleus® CI532 cochlear implant
Authors: Hey Matthias , Neben Nicole , Stöver Timo , Baumann Uwe , Mewes Alexander , Liebscher Tim , Schüssler Mark , Aschendorff Antje , Wesarg Thomas , Büchner Andreas , Greenham Paula , Hoppe Ulrich 
Published: March 2020

Abstract
Purpose
Hearing performance data was collected from a large heterogeneous group of subjects implanted with the Cochlear™ Nucleus® CI532 with Slim Modiolar Electrode, for the purposes of postmarket clinical follow-up. Data was analysed for factors which may predict postoperative speech recognition scores.

Methods
Data was collected retrospectively from five German clinics for 159 subjects from March 2017 to August 2018. Hearing thresholds and recognition scores for monosyllabic words in quiet and sentences in noise were measured preoperatively and at 3 and 6 months postoperatively.

Results
There was a mean gain of 44% points (95% CI 39–49%) at 6 months in monosyllable scores in quiet for implanted ears. Preoperative hearing thresholds in implant ears increased systematically with decreasing age; however, younger subjects had better baseline monosyllable scores with hearing aids compared with older subjects. Baseline performance alone explained 14% of the variation in postoperative scores. Residual hearing was preserved on average to within 22 dB at 250 Hz and 30 dB at 500 Hz of preoperative levels.

Conclusions
In a large and varied cohort of routinely treated hearing-impaired adults, speech recognition with the CI532 for German monosyllabic words in quiet at 6 months was equivalent to performance reported at one year or more in other published studies. Although younger subjects had poorer preoperative pure-tone thresholds, they had better preoperative word recognition scores compared with older subjects, and also had higher post implant scores. Further research is required to identify if this phenomenon is just applicable to German health system assessment and referral practices.
Sense of coherence and its relationship to participation, cancer-related fatigue, symptom burden, and quality of life in women with breast cancer participating in the OptiTrain exercise trial
Authors: Hiensch Anouk E , Bolam Kate A , Mijwel Sara , May Anne M , Wengström Yvonne 
Published: March 2020

Abstract
Purpose
This study examined the Sense of Coherence (SOC) of patients participating in the randomized controlled ‘Optimal Training for Women with Breast Cancer’ (OptiTrain) study and assessed how patient characteristics were associated with SOC. Secondary aims were to assess the association between SOC and patients’ participation in this study and to determine whether SOC moderates the effect of the 16-week exercise intervention on fatigue, quality of life (QoL), and symptom burden in women with breast cancer undergoing chemotherapy.

Methods
Modified Poisson regression analyses were conducted to determine the relative risk of weak-normal SOC versus strong SOC in terms of exercise session attendance, study and intervention dropout, and long absence rates. Analyses of covariance were performed to assess whether SOC moderated the effect of the exercise intervention (pinteraction ≤ 0.10).

Results
Two hundred and forty women with early breast cancer (mean age 53 ± 10) participated in the OptiTrain study. Women with strong SOC reported less fatigue, lower symptom burden, and higher QoL. Women with weak-normal SOC were significantly more likely to drop out from the OptiTrain study and tended to have slightly poorer exercise session attendance. Women with breast cancer and weaker SOC benefitted as much from the exercise intervention, in terms of fatigue and QoL, as those with stronger SOC (pinteraction > 0.10).

Conclusions
Strong SOC appears to be associated with a more positive subjective state of health. Women with weak-normal SOC may need additional support to encourage participation and adherence in exercise trials. Assessing SOC may assist clinicians to identify and provide extra support for participants with weak SOC, who may be less inclined to participate in exercise programs.
On the topology of metric f–K-contact manifolds
Authors: Goertsches Oliver , Loiudice Eugenia 
Published: March 2020

AbstractWe observe that the class of metric f–K-contact manifolds, which naturally contains that of K-contact manifolds, is closed under forming mapping tori of automorphisms of the structure. We show that the de Rham cohomology of compact metric f–K-contact manifolds naturally splits off an exterior algebra, and relate the closed leaves of the characteristic foliation to its basic cohomology.
Complete genome sequence and analysis of a novel lymphocystivirus detected in whitemouth croaker (Micropogonias furnieri): lymphocystis disease virus 4
Authors: Doszpoly Andor , Kaján Győző L. , Puentes Rodrigo , Perretta Alejandro 
Published: March 2020

AbstractA novel lymphocystivirus causing typical signs of lymphocystis virus disease in whitemouth croaker (Micropogonias furnieri) on the coast of Uruguay was detected and described recently. Based on genetic analysis of some partially sequenced core genes, the virus seemed to differ from previously described members of the genus Lymphocystivirus. In this study, using next-generation sequencing, the whole genome of this virus was sequenced and analysed. The complete genome was found to be 211,086 bp in size, containing 148 predicted protein-coding regions, including the 26 core genes that seem to have a homologue in every iridovirus genome sequenced to date. Considering the current species demarcation criteria for the family Iridoviridae (genome organization, G+C content, amino acid sequence similarity, and phylogenetic relatedness of the core genes), the establishment of a novel species (“Lymphocystis disease virus 4”) in the genus Lymphocystivirus is suggested.
Investment and labor income shares
Authors: Chortareas Georgios , Noikokyris Emmanouil 
Published: March 2020

AbstractWe explore empirically the determinants of labor shares focusing on the role of investment. We use a cross-country framework and consider up to 99 countries for the period 2004–2015. Our results reveal that the level of a country’s investment is a significant driving factor of the labor share of income. This evidence is in line with the predictions of neoclassical mechanisms for the role of investment in labor share. Among several other factors that we consider, as suggested by the extant empirical literature, we find strong evidence only for the degree of a country’s exposure to the international financial system, which is inversely related to the labor shares. Moreover, economic freedom amplifies the positive effect of gross fixed capital formation on labor income shares.
Bullous pemphigoid associated with the use of dipeptidil peptidase-4 inhibitors: analysis from studies based on pharmacovigilance databases
Authors: Molina-Guarneros Juan A. , Sainz-Gil María , Sanz-Fadrique Rosario , García Pilar , Rodríguez-Jiménez Pedro , Navarro-García Ester , Martin Luis H. 
Published: March 2020

AbstractBackground Bullous pemphigoid has been associated to dipeptidase-4 inhibitors. Objectives Addressing the potential Bullous pemphigoid-dipeptidase-4 inhibitors association based on pharmacovigilance data currently available in Spain in order to obtain a composite disproportionality estimator from all the data generated by the case-non case studies conducted to this date. Setting The Spanish Pharmacovigilance System for Human Use Drugs database. Method Case-non case study based on the Spanish Pharmacovigilance System for Human Use Drugs notifications submitted between 2007 and 2018 (n = 169,280), using the Medical Dictionary for Regulatory Activities term (Preferred Term) ‘pemphigoid’ for sitagliptin, vildagliptin, saxagliptin, linagliptin, and alogliptin (n = 1952). As negative control, we used acetaminophen, while furosemide was the positive control. A pooled reported odds ratio analysis in the French, Japanese, and Spanish national pharmacovigilance databases was performed. On The Spanish Pharmacovigilance System for Human Use Drugs, we conducted a bullous pemphigoid-metformin association analysis within the period 1982–2018. Main outcome measure Adverse reaction cases in pharmacovigilance databases and the disproportionality through the reporting odds ratio. Results Within The Spanish Pharmacovigilance System for Human Use Drugs, we found 45 cases of bullous pemphigoid in dipeptidase-4 inhibitors patients. Median age was 77 years (range 72–82). The median latency period was 7 months (range 0.23–86). The Bullous pemphigoid-dipeptidase-4 inhibitors association was established with a reporting odd ratio = 70.0 (95% confidence intervals 49.1–10.1). In the combined analysis of the three aforementioned pharmacovigilance databases, the pooled reporting odd ratio was 81.0 (95% confidence intervals 69.5–94.4). Conclusion The composite estimator for the three national pharmacovigilance databases yields clear evidence of a Bullous pemphigoid-dipeptidase-4 inhibitors association, which was statistically significant for both the pharmacological class as a whole and each of the dipeptidase-4 inhibitors agents under investigation. Metformin’s role in the incidence of bullous pemphigoid appeared casual rather than causal. No differences between Caucasian and Asian populations were noted.
Ready, Willing and Able? An Investigation of the Theory of Planned Behaviour in Help-Seeking for a Community Sample with Current Untreated Depressive Symptoms
Authors: Tomczyk S. , Schomerus G. , Stolzenburg S. , Muehlan H. , Schmidt S. 
Published: March 2020

AbstractApplying health behaviour change models, such as the theory of planned behaviour (TPB), to help-seeking for mental health problems can address the deficit in health care utilisation. However, previous studies largely focused on help-seeking intentions and not behaviour, which might be problematic due to the intention-behaviour gap. Hence, TPB and help-seeking were examined in a German community sample with current untreated depressive symptoms: 188 adults (Mage = 50.34; SD = 16.19; 70.7% female) participated in a baseline interview and survey measuring components of the TPB (attitudes, subjective norms and perceived behavioural control) and help-seeking intentions. They reported actual help-seeking from mental health professionals via telephone surveys 3 and 6 months later. To better understand the potential gap between help-seeking intentions and behaviour and to investigate the contributions of readiness, willingness and ability to seek help, two path models were constructed in accordance with the TPB controlling for covariates. Attitudes (β = .24), subjective norms (β = .25) and self-efficacy (β = .15) were significantly associated with intentions (R2 = 26%), which predicted help-seeking (Cox and Snell’s pseudo-R2 = 23%); controllability did not predict help-seeking. In sum, the TPB provides a reliable framework to explore help-seeking behaviour for mental health problems. Based on these findings, prevention efforts should focus on readiness and willingness to seek help (e.g. foster positive attitudes and social support of treatment). However, the role of ability, operationalised as perceived behavioural control and (perceived) barriers to help-seeking, warrants further research, as self-efficacy but not controllability was associated with help-seeking.
Against overconfidence: arguing for the accessibility of memorial justification
Authors: Egeland Jonathan 
Published: March 2020

AbstractIn this article, I argue that access internalism should replace preservationism, which has been called “a received view” in the epistemology of memory, as the standard position about memorial justification. My strategy for doing so is two-pronged. First, I argue that the considerations which motivate preservationism also support access internalism. Preservationism is mainly motivated by its ability to answer the explanatory challenges posed by the problem of stored belief and the problem of forgotten evidence. However, as I will demonstrate, access internalism also has the resources to provide plausible solutions to those problems. Second, I argue that preservationism faces a couple of problems which access internalism avoids. Doing so, I present a new scenario which, on the one hand, functions as a counterexample to preservationism, and, on the other hand, provides intuitive support for access internalism. Moreover, I also demonstrate how preservationism, in light of recent research in cognitive psychology, is vulnerable to skepticism about memorial justification, whereas access internalism remains unthreatened.
A Geometry-Based Multiple Testing Correction for Contingency Tables by Truncated Normal Distribution
Authors: Basak Tapati , Nagashima Kazuhisa , Kajimoto Satoshi , Kawaguchi Takahisa , Tabara Yasuharu , Matsuda Fumihiko , Yamada Ryo 
Published: March 2020

AbstractInference procedure is a critical step of experimental researches to draw scientific conclusions especially in multiple testing. The false positive rate increases unless the unadjusted marginal p-values are corrected. Therefore, a multiple testing correction is necessary to adjust the p-values based on the number of tests to control type I error. We propose a multiple testing correction of MAX-test for a contingency table, where multiple χ2-tests are applied based on a truncated normal distribution (TND) estimation method by Botev. The table and tests are defined geometrically by contour hyperplanes in the degrees of freedom (df) dimensional space. A linear algebraic method called spherization transforms the shape of the space, defined by the contour hyperplanes of the distribution of tables sharing the same marginal counts. So, the stochastic distributions of these tables are transformed into a standard multivariate normal distribution in df-dimensional space. Geometrically, the p-value is defined by a convex polytope consisted of truncating hyperplanes of test’s contour lines in df-dimensional space. The TND approach of the Botev method was used to estimate the corrected p. Finally, the features of our approach were extracted using a real GWAS data.
Determination of the elemental composition and antioxidant properties of dates (Phoenix dactyliferia) originated from different regions
Authors: Kuras Marzena Joanna , Zielińska-Pisklak Monika , Duszyńska Justyna , Jabłońska Joanna 
Published: March 2020

AbstractDue to the growing interest in running a healthy life, including the diet a special interest has been put in searching for products that are rich in nutrients, macro and micronutrients and vitamins. Dates are the fruits that meet these requirements and show multidirectional pro-health effects. These fruits are a source of potassium and other macro- and micronutrients. They have antioxidant properties thanks to the content of flavonoids and polyphenols. The elemental composition (Al, Ca, Cu, Fe, K, Mg, Mn, P, Sr and Zn) and antioxidant properties (total equivalent antioxidant capacity, total polyphenol content, total flavonoid content) of various dates from different regions of the world was determined. The results have shown that the peel and flesh of dates differ significantly in chemical composition. The peel is significantly richer in chemical components of biological importance. Discriminant analysis of the results obtained for dates originated from various regions indicated that the main factor determining the tested chemical composition is the place of cultivation, not the variety.
Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms
Authors: Blessin Niclas C. , Spriestersbach Patrick , Li Wenchao , Mandelkow Tim , Dum David , Simon Ronald , Hube-Magg Claudia , Lutz Florian , Viehweger Florian , Lennartz Maximillian , Fraune Christoph , Nickelsen Vera , Fehrle Wilfried , Göbel Cosima , Weidemann Sören , Clauditz Till , Lebok Patrick , Möller Katharina , Steurer Stefan , Izbicki Jacob R. , Sauter Guido , Minner Sarah , Jacobsen Frank , Luebke Andreas M. , Büscheck Franziska , Höflmayer Doris , Wilczak Waldemar , Burandt Eike , Hinsch Andrea 
Published: March 2020

AbstractPurposeImmune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8+lymphocytes in a wide range of different cancer types and subtypes.MethodsThe density of CD8+lymphocytes was compared across different cancer types using tissue microarrays (TMAs) composed of up to 50 tumor samples each from 84 different cancer types and subtypes. In total 2652 cancers and 608 normal tissues were successfully analyzed by CD8 immunohistochemistry followed by automated image analysis of digitized slides.ResultsWe found that the median CD8+lymphocyte counts ranged from 6 cells/mm2in pleomorphic adenoma up to 1573 cells/mm2in Hodgkin’s lymphoma. The CD8 counts were generally lower in normal tissues compared to cancer tissues. Blood vessels of the spleen were the only non-lymphatic tissue staining positive for CD8. Tumor types approved for checkpoint inhibitor therapy, including malignant melanoma (81), muscle invasive urothelial carcinoma (119), small cell lung cancer (120), clear cell renal cell cancer (153), squamous cell carcinoma (189) and adenocarcinoma of the lung (328) as well as Hodgkin’s lymphoma (1573) were all ranking among the upper half of our list. Comparably high CD8 densities (median cells/mm2) were also found in several rare and aggressive cancer types including Merkel cell carcinoma (70), angiosarcoma (95), anaplastic thyroid cancer (156) and embryonal carcinoma of the testis (186). In 73 of the 84 analyzed cancer types, the highly variable CD8 counts occasionally exceeded the average CD8 count of tumors for which checkpoint inhibitors have been approved.ConclusionThese data support the concept that among most tumor types at least some individual cancers may benefit from treatment with immune checkpoint inhibitors.
Effect of cavity flow control on high-speed train pantograph and roof aerodynamic noise
Authors: Kim Hogun , Hu Zhiwei , Thompson David 
Published: March 2020

AbstractThe pantograph and its recess on the train roof are major aerodynamic noise sources on high-speed trains. Reducing this noise is particularly important because conventional noise barriers usually do not shield the pantograph. However, less attention has been paid to the pantograph recess compared with the pantograph. In this paper, the flow features and noise contribution of two types of noise reduction treatments rounded and chamfered edges are studied for a simplified high-speed train pantograph recess, which is represented as a rectangular cavity and numerically investigated at 1/10 scale. Improved delayed detached-eddy simulations are performed for the near-field turbulent flow simulation, and the Ffowcs Williams and Hawkings aeroacoustic analogy is used for far-field noise prediction. The highly unsteady flow over the cavity is significantly reduced by the cavity edge modifications, and consequently, the noise radiated from the cavity is reduced. Furthermore, effects of the rounded cavity edges on the flow and noise of the pantographs (one raised and one folded) are investigated by comparing the flow features and noise contributions from the cases with and without rounding of the cavity edges. Different train running directions are also considered. Flow analysis shows that the highly unsteady flow within the cavity is reduced by rounding the cavity edges and a slightly lower flow speed occurs around the upper parts of the raised pantograph, whereas the flow velocity in the cavity is slightly increased by the rounding. Higher pressure fluctuations occur on the folded pantograph and the lower parts of the raised pantograph, whereas weaker fluctuations are found on the panhead of the raised pantograph. This study shows that by rounding the cavity edges, a reduction in radiated noise at the side and the top receiver positions can be achieved. Noise reductions in the other directions can also be found.