bluuebunny/crossref_metadata_2025_split huggingface dataset:
SHORT‐ROOT 1 is critical to cell division and tracheary element development in rice roots
Authors: Xing Yadi , Wang Nan , Zhang Tianquan , Zhang Qiuli , Du Dan , Chen Xinlong , Lu Xin , Zhang Yingying , Zhu Maodi , Liu Mingming , Sang Xianchun , Li Yunfeng , Ling Yinghua , He Guanghua 
Published: November 2020

SummaryThe exocyst is a key factor in vesicle transport and is involved in cell secretion, cell growth, cell division and other cytological processes in eukaryotes. EXO70 is the key exocyst subunit. We obtained a gene, SHORT‐ROOT 1 (SR1), through map‐based cloning and genetic complementation. SR1 is a conserved protein with an EXO70 domain in plants. SR1 mutation affected the whole root‐development process: producing shorter radicles, adventitious roots and lateral roots, and demonstrating abnormal xylem development, resulting in dwarfing and reduced water potential and moisture content. SR1 was largely expressed in the roots, but only in developing root meristems and tracheary elements. The shortness of the sr1 mutant roots was caused by the presence of fewer meristem cells. The in situ histone H4 expression patterns confirmed that cell proliferation during root development was impaired. Tracheary element dysplasia was caused by marked decreases in the inner diameters of and distances between the perforations of adjacent tracheary elements. The membrane transport of sr1 mutants was blocked, affecting cell division in the root apical region and the development of root tracheary elements. The study of SR1 will deepen our understanding of the function of EXO70 genes in Oryza sativa (rice) and guide future studies on the molecular mechanisms involved in plant root development.
Sensors for the quantification, localization and analysis of the dynamics of plant hormones
Authors: Isoda Reika , Yoshinari Akira , Ishikawa Yuuma , Sadoine Mayuri , Simon Rüdiger , Frommer Wolf B. , Nakamura Masayoshi 
Published: November 2020

SummaryPlant hormones play important roles in plant growth and development and physiology, and in acclimation to environmental changes. The hormone signaling networks are highly complex and interconnected. It is thus important to not only know where the hormones are produced, how they are transported and how and where they are perceived, but also to monitor their distribution quantitatively, ideally in a non‐invasive manner. Here we summarize the diverse set of tools available for quantifying and visualizing hormone distribution and dynamics. We provide an overview over the tools that are currently available, including transcriptional reporters, degradation sensors, and luciferase and fluorescent sensors, and compare the tools and their suitability for different purposes.
Immediate Effects of Limb Rotational Kinesio Tape Application on Upper Quarter Y-Balance Test Scores
Authors: Dittmer Alyssa , Tomchuk David , Fontenot David R. 
Published: November 2020

Context: Rounded shoulder posture is a common problem in the athletic population. Recently Kinesio tape has been utilized to improve balance, proprioception, and posture. However, the literature has been unable to provide definitive answers on the efficacy of Kinesio tape use. Objective: To determine the immediate effect of the limb rotational Kinesio tape application on the dynamic balance and proprioception of the shoulder measured by the Y-Balance Upper Quarter Test (YBT-UQ) in male collegiate athletes. Design: Cross-sectional. Setting: Sports medicine research laboratory.Participants: Nineteen healthy male collegiate National Association of Intercollegiate Athletics athletes (including rodeo, baseball, football, and soccer) with a mean age of 19.8 (1.4) years. Interventions: Subjects were randomized into Kinesio tape and non-Kinesio tape groups. The limb rotational Kinesio tape application was applied to the Kinesio tape group, while the non-Kinesio tape group received no intervention. Each group performed the YBT-UQ, which requires reaching in 3 directions in a push-up position, before and after the randomized intervention on a single day. Main Outcome Measures: The variables of interest included the maximum reach distance in each of the 3 directions and the composite score for both trials between the Kinesio tape and non-Kinesio tape groups. Each score was normalized against the subject’s limb length. Results: No statistically significant improvements in any YBT-UQ scores were observed following either the Kinesio tape or non-Kinesio tape intervention. Conclusions: Applying the limb rotational Kinesio tape technique did not improve immediate YBT-UQ scores in a male collegiate athletic population with rounded shoulder posture. The use of Kinesio tape to improve immediate closed kinetic chain function in male collegiate athletes with rounded shoulder posture cannot be supported.
External forcing mechanisms controlling the North Atlantic coastal upwelling regime during the mid-Holocene
Authors: Hernández Armand , Cachão Mário , Sousa Pedro , Trigo Ricardo M. , Luterbacher Jürg , Vaquero José M. , Freitas Maria C. 
Published: November 2020

Abstract
Nearshore upwelling along the eastern North Atlantic margin regulates regional marine ecosystem productivity and thus impacts blue economies. While most global circulation models show an increase in the intensity and duration of seasonal upwelling at high latitudes under future human-induced warmer conditions, projections for the North Atlantic are still ambiguous. Due to the low temporal resolution of coastal upwelling records, little is known about the impact of natural forcing mechanisms on upwelling variability. Here, we present a microfossil-based proxy record and modeling simulations for the warmest period of the Holocene (ca. 9–5 ka) to estimate the contribution of the natural variability in North Atlantic upwelling via atmospheric and oceanic dynamics. We found that more frequent high-pressure conditions in the eastern North Atlantic associated with solar activity and orbital parameters triggered upwelling variations at multidecadal and millennial time scales, respectively. Our new findings offer insights into the role of external forcing mechanisms in upwelling changes before the Anthropocene, which must be considered when producing future projections of midlatitude upwelling activity.
Health of transgender men in low-income and middle-income countries: a scoping review
Authors: Scheim Ayden , Kacholia Vibhuti , Logie Carmen , Chakrapani Venkatesan , Ranade Ketki , Gupta Shaman 
Published: November 2020

IntroductionDespite the rapid growth of research on transgender (trans) health globally, the extent of research on trans men and other transmasculine persons assigned the female sex at birth remains unclear. We, therefore, conducted a scoping review on trans men’s health in low-income and middle-income countries (LMICs).MethodsThe review included peer-reviewed articles and conference abstracts, and grey literature published from 1 January 1999 to 5 July 2019 in English, French, Hindi or Spanish and reporting original quantitative and/or qualitative data on the health of trans men or transmasculine persons living in LMIC. Studies were excluded if they did not disaggregate data for trans men or if they only described surgical techniques or laboratory values.ResultsWe included 53 studies (42 peer-reviewed and 11 grey literature) from 19 LMIC. Most were conducted in higher-middle-income countries (n=12) and in Latin America (n=16, 30.2%), the Middle East (n=14, 26.4%) or Sub-Saharan Africa (n=12, 22.6%) and published in 2014 or later (n=44, 83.0%). Approximately half of studies used quantitative methods (52.8%, n=28), of which 64.3% (n=18) had fewer than 50 participants and 14.2% (n=4) had over 150. Across study designs, social determinants of health and gender-affirming care were the most commonly represented domains (49.1% and 47.1% of studies respectively), with common themes including gender-based violence, coercion and discrimination as well as unprescribed hormone use. Other domains represented included mental health (32.1%), sexual and reproductive health (24.5%), general healthcare access (18.9%), physical health (9.4%) and substance use (9.4%).ConclusionGreater inclusion and disaggregation of trans men and transmasculine persons in global health research is needed to support sex- and gender-based analyses of trans health. Community-based research approaches and theoretically driven research may help to increase the relevance and rigour of such research. Funders should invest in research on trans men’s health in LMIC.
Assessment of postoperative gastrointestinal motility in colorectal surgery: a study with the Motilis 3D-transit system
Authors: Nors Jesper , Klinge Mette Winther , Sommer Thorbjørn , Laurberg Søren , Krogh Klaus , Funder Jonas Amstrup 
Published: November 2020

Purpose
Postoperative recovery following colorectal surgery remains impaired by severe complications including postoperative ileus (POI). Human studies of POI have been limited by a lack of safe and easy-to-use objective methods. Motilis 3D-transit is a completely ambulatory, minimally invasive system whereby electromagnetic capsules are followed by external sensors during their passage of the gastrointestinal (GI) tract. The aim of this study was to evaluate the applicability of the 3D-transit system in a surgical setting.

Method
We included 12 patients as a substudy of the randomised double blind controlled Stimulation of the Autonomic Nervous System In Colorectal Surgery by perioperative nutrition (SANICS)-II trial undergoing elective segmental colonic resection with primary anastomosis at Aarhus University Hospital and Randers Regional Hospital, Denmark. To study region-specific motility, three electromagnetic capsules were administered. One was taken 3 hours before surgery, the next was taken 1 hour before surgery, while the third was placed distal to the anastomosis during surgery. Total and regional GI transit times as well as time until first propulsive colonic contraction were determined.

Results
All patients tolerated the setup well with no adverse events related to the 3D-transit system. Large variations were found in total GI transit time (26.7–127.6 hours), gastric emptying (0.07–>106.9 hours), small intestinal (1.2–58.4 hours) and colorectal transit time (14.3–>118.1 hours). Time from end of surgery to first propulsive movement in the colon varied from 3.9 to 85 hours. No correlation was found between parameters of GI motility and tolerance of an oral diet or recovery of bowel function.

Conclusion
The 3D-transit system allows safe assessment of GI motility in patients operated with segmental colonic resections and primary anastomosis for colorectal cancer. Postsurgical motility varies significantly between patients.
COVID-19 in pregnancy: the foetal perspective—a systematic review
Authors: Dube Rajani , Kar Subhranshu Sekhar 
Published: November 2020

ObjectiveWe aimed to conduct a systematic review of the available literature to determine the effects of confirmed cases of COVID-19 in pregnant women from the foetal perspective by estimation of mother to child transmission, perinatal outcome and possible teratogenicity.MethodsData sources: eligible studies between 1 November 2019 and 10 August 2020 were retrieved from PubMed, Embase, LitCovid, Google Scholar, EBSCO MEDLINE, CENTRAL, CINAHL, MedRXiv, BioRXiv and Scopus collection databases. English language case reports, case series and cohort studies of SARS-CoV-2 confirmed pregnant women with data on perinatal outcome, congenital anomalies and mother to child transmission were analysed.Results38 case reports, 34 cohort and case series describing 1408 neonates were included for evidence acquisition of mother to child transmission. 29 case reports and 31 case series and cohort studies describing 1318 foetuses were included for the evaluation of perinatal outcome and congenital anomalies. A pooled proportion of 3.67% neonates had positive SARS-CoV-2 viral RNA nasopharyngeal swab results and 7.1% had positive cord blood samples. 11.7% of the placenta, 6.8% of amniotic fluid, 9.6% of faecal and rectal swabs and none of the urine samples were positive. The rate of preterm labour was 26.4% (OR=1.45, 95% CI 1.03 to 2.03 with p=0.03) and caesarean delivery (CS) was 59.9% (OR=1.54, 95% CI 1.17 to 2.03 with p=0.002). The most common neonatal symptom was breathing difficulty (1.79%). Stillbirth rate was 9.9 per 1000 total births in babies born to COVID-19 mothers.ConclusionChances of mother to child transmission of the SARS-CoV-2 virus is low. The perinatal outcome for the foetus is favourable. There is increased chances of CS but not preterm delivery.The stillbirth and neonatal death rates are low. There are no reported congenital anomalies in babies born to SARS CoV-2 positive mothers.
Acupuncture for postprostatectomy incontinence: a systematic review
Authors: Chen Huan , Liu Yu , Wu Jiani , Liang Fanrong , Liu Zhishun 
Published: November 2020

BackgroundPostprostatectomy incontinence (PPI) is a clinically significant condition that is caused by surgery of prostate. Study showed that electroacupuncture can reduce urine leakage among women with stress urinary incontinence (SUI), but few was known about its efficacy and safety for men with PPI. This study aims to conduct a systematic review to evaluate efficacy and safety of acupuncture for men with PPI compared with other non-surgical treatment.MethodsSeven databases were searched for all randomised controlled trials (RCTs) on acupuncture for men with PPI up to August 2020. Risks of bias of included studies were assessed using RevMan V.5.3. Narrative analysis was conducted.ResultsSeven studies with 830 men with PPI were included in the review. Studies showed that acupuncture can significantly improve score of International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form for men with urgent urinary incontinence (UUI) when compared with medicine (p<0.05). It showed a significant better overall response rate when acupuncture was combined with solifenacin for men with UUI (p<0.05), or with pelvic floor muscle training (PFMT) (p<0.001), or with PFMT and medicine together for men with UUI or SUI (p<0.01), compared with control groups. No adverse event was reported in the studies. However, the quality of evidences was considered low generally.ConclusionThe results showed that acupuncture could be beneficial for men with PPI when applied alone or as an adjunction to other conservative therapies and medicines, however, the quality of evidence was considered low and inconclusive in this review.PROSPERO registration numberThis study has been registered at PROSPERO system with ID No. CRD42019091164.
In Vivo Kinematics of the Thumb Carpometacarpal Joint During Flexion and Abduction
Authors: Tada Kaoru , Tachiya Hiroshi , Kurosawa Akihiro , Nakada Mika , Matsuta Masashi , Murai Atsuro , Tsuchiya Hiroyuki 
Published: November 2020

Background: Despite the movement of the thumb carpometacarpal joint has been studied, many unclarified points remain regarding the movement of this joint. The purpose of this study was to evaluate the in vivo kinematics of the thumb carpometacarpal joint during flexion and abduction using computed tomography images. Methods: The subjects were 9 healthy males. Computed tomography images were obtained in 4 equally-divided positions from maximum extension to maximum flexion, and maximum adduction to maximum abduction of the thumb. A three-dimensional model was constructed from these images, and the models of each position were superimposed with reference to the trapezium. The amount of angular change around the bone axes of first metacarpal bone and rotation axes were evaluated. Results: We found that the first metacarpal bone showed relatively simple behavior during abduction. However, during flexion, it exhibited a particular movement in which the amount of angular change of the metacarpal bone with respect to the trapezium rapidly increased with deep flexion. Conclusions: These results suggest that the thumb carpometacarpal joint exhibits a special movement during flexion, especially deep flexion.
FDA Approval Summary: Selpercatinib for the Treatment of Lung and Thyroid Cancers withRETGene Mutations or Fusions
Authors: Bradford Diana , Larkins Erin , Mushti Sirisha L. , Rodriguez Lisa , Skinner Amy M. , Helms Whitney S. , Price Lauren S.L. , Zirkelbach Jeanne Fourie , Li Yangbing , Liu Jiang , Charlab Rosane , Turcu Francisca Reyes , Liang Dun , Ghosh Soma , Roscoe Donna , Philip Reena , Zack-Taylor Autumn , Tang Shenghui , Kluetz Paul G. , Beaver Julia A. , Pazdur Richard , Theoret Marc R. , Singh Harpreet 
Published: November 2020

AbstractOn May 8, 2020, the FDA granted accelerated approval to selpercatinib for (i) adult patients with metastatic RET fusion–positive non–small cell lung cancer (NSCLC), (ii) adult and pediatric patients ≥12 years of age with advanced or metastatic RET-mutant medullary thyroid cancer who require systemic therapy, and (iii) adult and pediatric patients ≥12 years of age with advanced or metastatic RET fusion–positive thyroid cancer who require systemic therapy and who are radioactive iodine refractory (if radioactive iodine is appropriate). Approval was granted on the basis of the clinically important effects on the overall response rate (ORR) with prolonged duration of responses observed in a multicenter, open-label, multicohort clinical trial (LIBRETTO-001, NCT03157128) in patients whose tumors had RET alterations. ORRs within the approved patient populations ranged from 64% [95% confidence interval (CI), 54–73] in prior platinum-treated RET fusion–positive NSCLC to 100% (95% CI, 63–100) in systemic therapy–naïve RET fusion–positive thyroid cancer, with the majority of responders across indications demonstrating responses of at least 6 months. The product label includes warnings and precautions for hepatotoxicity, hypertension, QT interval prolongation, hemorrhagic events, hypersensitivity, risk of impaired wound healing, and embryo-fetal toxicity. This is the first approval of a drug specifically for patients with RET alterations globally.
The State of the Pandemic
Authors: Toscano Alberto 
Published: November 2020

Abstract
The Covid-19 pandemic has further intensified a crisis in the functions and the perception of the state. It has also revealed underlying contradictions in both mainstream and radical ideologies of the state. A desire for the state as guarantor of public welfare vies with fear of the state’s hypertrophic capacities for surveillance and control. Following a brief exploration of the intimate modern connection between plagues and the state, the article tries to map some of the ways in which the state has been at stake in political and theoretical commentaries on the pandemic. Is an epidemiological politics from below, beyond the plague state, possible? Can recent emergency measures be seen as incomplete or inverted anticipations of a communist use of the state of exception? Or is the primacy of the political we are currently experiencing a mere fetish, indissociable from the rule of capital?
Public Theology and Global Governance: Weak Actors in Lawmaking for the World Economy
Authors: Halliday Terence C. 
Published: November 2020

Abstract
The world confronts an enormous range of challenges in the global economy. A far-reaching enterprise has arisen to meet these challenges by producing laws and regulations to shape and protect global commercial and financial markets. This article considers how a Christian theology can guide the highly consequential processes of creating law for world commerce. First, from the perspective of the sociology of globalization, law and markets, the article describes findings from current research on who makes global law and how they make that law in the United Nations’ principal body for the creation of private international law. Second, the article proposes that public theology offers Christian theological principles and middle level axioms to deepen and extend the dimensionality of global lawmaking, thereby offering ethical guidance for prospective global lawmaking. It sharpens focus by appraising the participation and creativity of weak actors in global lawmaking. Third, the article turns to praxis for weak actors in global lawmaking and concludes with considerations that may foster mutually productive dialog between social scientists and public theologians of the global.
The Refugee and the Sovereign State
Authors: Glanville Luke 
Published: November 2020

Abstract
Some Christian political theorists and theologians counter calls for greater generosity toward refugees by appealing to the prerogatives of state sovereignty, the preferential love for fellow-citizens, and the priority of loving nearby neighbours over distant strangers. This article responds to each argument, arguing that the right to exclude outsiders is not an immutable aspect of sovereignty, the construction of a social contract among fellow-citizens does not justify abandoning duties to non-citizens, and, in a highly globalized world, the obligation to love one’s neighbour is not rightly circumscribed by geography. It further argues that Jesus’s parable of the good Samaritan serves as a foil through which it can be seen that many sovereign states not only fail to love the displaced neighbour by providing refuge, but, like the priest and the Levite, go out of their way to keep refugees at a distance—and, like the robbers, even contribute to their vulnerability and suffering.
What International Bureaucrats (Really) Want
Authors: Ege Jörn 
Published: November 2020

Abstract
The secretariats of international organizations (international public administrations [IPA s]) constitute the institutional grid of global governance. While recent research has provided valuable insights into the independent capacities of international organizations (IO s) and the influence of IPA s, we lack systematic knowledge of how scholars conceptualize the preferences of IO staff. This is lamentable because understanding the (unifying) motivations of “international civil servants” helps us to make sense of their behavior and influence during the adoption and application of IO policies. To review how IPA studies conceptualize the preferences of international bureaucrats, this article suggests a fourfold typology of ideal-typical bureaucratic behavior. It distinguishes between the underlying behavioral logic and dominant bureaucratic goal orientation. Applying the typology to thirty-nine journal articles allows us to map IPA preferences and behavior, and shows that the literature predominantly views IPA s as behaving responsibly and less self-centeredly than could be expected from economic accounts of bureaucracy.
Priorities, Partners, Politics
Authors: Hanrieder Tine 
Published: November 2020

Abstract
The World Health Organization (WHO) is once more asked to reinvent itself and become more effective. This essay discusses recurrent reform proposals directed at the WHO which, in different ways, ask it to find a strategic focus and thereby its niche in the crowded global health arena. Looking back at decades of reform endeavors at the WHO, it exposes the contradictions and unresolved normative conflicts with regard to the WHO’s priorities. Ultimately, the WHO’s effectiveness hinges on Member State support for public authority in global health, and thus the political commitment to protect it against capture by special interests.