bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directions of emerging structural changes in the use of biometric data in Russia
Authors: Seliverstova N. S. 
Published: December 2024

Objective: to identify the emerging structural changes in the use of biometrics in Russia, namely the multiple growth of market participants and brands, the multiple growth of the number of biometrics samples in a single biometric system, and the multiple growth of market volume and institutional design of biometrics use in Russia. Methods: general scientific, abstract-logical, dialectical, phenomenological methods, observation, description. Results: the article describes approaches to the use of biometric data in some regions of the world, identifies the risks and potential benefits of wider use of biometric data, summarizes the main trends in the use of biometric personal data in Russia, presents a comprehensive author’s approach to the analysis of structural changes in the economy, taking as an example thedevelopment of solutions using biometric personal data for the identification of individuals. Scientific novelty: the author proposes to consider the formation of structural shift by identifying its four components and qualitatively assessing their level of formation (low, medium, and high); shows the formation of macro-shifts from micro-level initiatives and sequential passage of the stages of specific structural changes, complex micro-shifts, institutionalization andconsolidation of new practices. In addition, the process of implementation of structural shifts from the macro- to the micro-level is traced, which consists in the changes more widely covering economic agents compared to the stage of a structural shift formation. All this constitutes a comprehensive author’s approach to the regularities of the structural shifts developmentin the economy. Practical significance: clarification of interrelations between the processes of structural change will improve the programs of socio-economic development of regions, industrial policy for medium- and high-tech industries through the use of modern technological methods of identification and authentication of customers and employees with biometrics. It may also create a basis for deepening the existing knowledge in the development of biometric technologies in Russia and expanding the practice of their application.
Providing digital security of healthcare system with criminal-legal means
Authors: Shutova A. A. 
Published: December 2024

Objective: to form a theoretical concept of criminal-legal protection of digital healthcare by identifying the key criminal risks; to perform a terminological analysis of the concept of “digital security of the healthcare system” and to analyze the possibility of its use in legal theory and practice. Methods: the article uses the universal dialectical method of cognition, as well as general scientific (analysis, synthesis, induction, deduction) and specific scientific (formal-legal) methods of research. Results: based on the conducted research, the key criminal risks and trends of digital healthcare were identified; legal and terminological analysis of the concept of “digital security of the healthcare system” was performed. The author has formulates the definitions of such concepts as “digital security of the healthcare system”, “ensuring digital security of the healthcare system” and “digital threat”, and reveals a set of reasons for legal regulation of digital security of the healthcare system. Scientific novelty: the author has developed a theoretical concept of criminal-legal protection of digital security of the healthcare system, which includes three groups of elements: key criminal risks in healthcare digitalization (risks arising in the circulation of digital information in the healthcare system; risks inherent in medical devices based on digital technologies; risks of critical information infrastructure in the Russian Federation); legal and terminological apparatus of digital securityof the healthcare system; factors that determine the need for legal regulation of digital security of the healthcare system by criminal-legal means (digitalization of healthcare; risks of hacking or unauthorized access to medical devices based on digital technologies; workload of medical workers; increased social danger of unlawful encroachments in the field of digitalhealthcare, etc.). Practical significance: the proposals and conclusions of the study can be used to improve criminal legislation and practice of its application, as well as to form a scientific basis for interdisciplinary research at the intersection of criminal law science and digital technologies.
Vehicle routing optimization for perishable goods to develop a sustainable supply chain in the Bangladeshi emerging markets: An integrated location inventory model
Authors: Lingkon Md. Limonur Rahman , Dash Adri 
Published: December 2024

Abstract

In emerging economies, there has been a growth in the demand for perishable goods. The perishability of items, however, presents significant difficulties for businesses trying to establish an inaugurated supply chain. In this work, we provide an integrated location-inventory-routing model for perishable goods that considers product freshness and carbon emissions. First, an analysis is conducted on the perishable items' economic cost, freshness, and carbon emission levels. Second, a model of multi-objective planning is constructed to obtain the lowest economic cost and carbon emissions as well as the maximum freshness of the product. Based on the real location-inventory-routing scenario, limitations are formed. Third, the model is solved using the YALMIP toolkit, yielding the best answer to this challenging multi-objective issue. Lastly, the case study and the sensitivity of the vehicle speed to the outcomes confirm the viability and efficacy of the suggested approach. From the standpoint of global optimization, it is shown that the integrated model presented in this study can significantly improve the efficiency of the supply chain management of perishable goods. That vehicle speed may significantly affect carbon emissions and associated costs.
Prevalence and molecular epidemiology of carbapenem resistance in Asia: A systematic review and meta-analysis
Authors: Jayathilaka Nishadi , Denagamagei Shehana , Nakkawita Dilini , Senaratne Thamarasi 
Published: December 2024

Abstract

Background
Carbapenems are a group of last-resort antibiotics used to treat serious life-threatening infections. The emergence of resistance to carbapenems is a major public health threat. However, comprehensive information on the prevalence and molecular epidemiology of carbapenem resistance (CR) among Asian countries is lacking. Therefore, we aimed to determine the prevalence of CR and associated molecular determinants quantitatively among Asian countries.
Methods
In this systematic review and meta-analysis, we searched published reports in electronic databases such as PubMed, ScienceDirect, the Cochrane Library and Web of Science from 1st of January 2014 to 31st of January 2024 that fulfilled these criteria; original studies conducted in Asian countries, including clinical isolates, and published in English. Data extraction and risk of bias assessment was performed by two independent reviewers. The pooled prevalence of CR with a 95% confidence interval (CI) was computed with a random effects model. Heterogeneity across studies was determined by I2. The geographical location, income level, publication year and sample size were analysed as subgroups.
Results
We identified 2518 eligible studies, of which 37 assessed the CR prevalence data of 10,433 patients. The pooled prevalence (PPr) of CR was 31.3% (95% CI; 0.22 to 0.40; I2 = 99.9%; P = 0.00). A trend of CR incidence was observed from 2004–2023, with PPr values ranging from 7.4–50.6%. Variation in the distribution of CR genes was observed, with blaNDM being the most common gene, followed by blaOXA and blaKPC. Univariate meta–regression analysis indicated that geographical location, income level, publication year and sample size did not significantly affect heterogeneity (p < 0.05).
Conclusion
The results suggest that surveillance of CR among Asian countries is essential to reduce the burden of antibiotic resistance. Mitigating the impact of CR infections will safeguard the efficacy of carbapenems for future generations and reduce further dissemination of CR genes.
Systematic review registration:
This review is registered at PROSPERO (CRD42024515806).
Insights into the Biology and Insecticide Susceptibility of the Secondary Malaria Vector Anopheles parensis in an Area with Long-term Use of Insecticide-Treated Nets in North-Western Tanzania
Authors: Mapua Salum Abdallah , Nambunga Ismail Hassan , Odero Joel Ouma , Mkandawile Gustav , Masalu John Paliga , Kahamba Najat Feruz , Hape Emmanuel Elirehema , Matowo Nancy Stephen , Tripet Frederic , Okumu Fredros Oketch 
Published: December 2024

Abstract

Background
The Anopheles funestus group includes at least 11 sibling species, with Anopheles funestus Giles being the most studied and significant malaria vector. Other species, like Anopheles parensis, are understudied despite their potential role in transmission. This paper reports unusually high densities of An. parensis in north-western Tanzania, along with field observations on its biology and insecticide susceptibility.
Findings:
Mosquitoes were collected in three villages in Misungwi district, north-western Tanzania using CDC light traps and battery-powered aspirators indoors and human-baited double net traps outdoors. Female Anopheles adults were morphologically sorted and identified by PCR, and a subset tested by ELISA for vertebrate blood meal sources and Plasmodium sporozoite infections. Insecticide susceptibility was assessed using WHO protocols. Unfed females were dissected to assess parity, gonotrophic status and insemination status, while blood-fed females were monitored for oviposition to estimate egg counts. The prevalence of Anopheles parensis was generally below 24% across all sites, except in Ngaya village, where it unexpectedly constituted 84% of PCR-amplified An. funestus s.l.. This species was present in both indoor and outdoor collections, yet the females exclusively fed on non-human vertebrates, with no human blood meals detected. Parity rates were approximately 49% for resting and 46% for host-seeking females, with slightly higher percentages of both parous and inseminated females in the dry season compared to the wet season. Most parous females had oviposited once or twice, with those in the dry season ovipositing significantly more eggs. The average wing length of female An. parensis was 2.93 mm; and there was no significant impact of body size on parity, fecundity, or insemination. The An. parensis mosquitoes were fully susceptible to pyrethroids, carbamates, organophosphates, and organochlorides.
Conclusion
This study offers insights into the behaviors and insecticide susceptibility of An. parensis. Primarily feeding on non-human hosts, An. parensis is less significant in malaria transmission than more anthropophilic vectors. Unlike the pyrethroid-resistant An. funestus s.s., An. parensis remains fully susceptible to public health insecticides, despite the use of insecticidal bed nets. These findings provide a foundation for future research and may inform control strategies targeting residual malaria transmission involving An. parensis.
Pooled Estimates of stillbirth in Ethiopia: Systematic review and Meta-analysis, 2013-2024.
Authors: Ahmed Ahmed Tahir , Abdilahi Mohamed Arab , Abas Abdilahi Haji , Ali Habon Bade 
Published: December 2024

Abstract

Background
Stillborn babies are those that are born with no signs of life at or after 28 weeks of gestation or weighing more than 1000 grams. The tragedy that is overlooked in the global agenda and policies is neglected. It is more common in Ethiopia despite routine maternal and child interventions. Pocket studies have been conducted with different estimates across countries, but no pooled studies exist. Thus, this study aims to better understand stillbirth in Ethiopia and inform policy makers and program implementers.
Methods
A systematic review and meta-analysis was performed between 2013 and 2024 by adhering to the PRISMA guidelines and exhaustively searching for outcomes of interest in different databases, such as PubMed/Medline, Science Direct, HINARI, SCOPUS and Google Scholar. Data selection, extraction and quality assessment were performed by two authors independently. The I2 test statistic was used to test heterogeneity among studies, and a random-effects model was used for pooled stillbirth estimation. Subgroup analysis was also performed to address heterogeneity among studies. Zotero was used for cleaning and study selection, whereas all the statistical analyses were performed with Stata version 16 software.
Result
Among a total of 997 studies found in databases, 16 studies were included in the analysis. The overall pooled magnitude of stillbirth is 90 per 1000 births 95% CI (7–12) in Ethiopia. Subgroup analysis revealed discrepancies in rates across regions, study years and settings. Subgroup analysis revealed that recent studies (2020–2021) have a greater magnitude of stillbirth, with 12 per 1000 births within the 95% C range (5–19), than earlier studies (2013–2019), with 8 within the 95% CI range (6–10).
Conclusion
The pooled magnitude of stillbirth is much greater in Ethiopia Compared with the global target rate of 12, which is set for 2030. It is also higher than in African countries. The stillbirth rate is also increasing over time in the country. The review informs policy makers and program implementers concerning the burden and negligence of stillbirth in the country despite its far-reaching effect on the mental health of mothers. Policy makers and health actors should adjust and improve the quality of maternal health services, including maternal perinatal death surveillance, and respond with a special focus on stillbirth to reach the global target.
A novel prognostic score for endometrial cancer patients undergoing lymphadenectomy
Authors: Maehana Tomoka , Kawahara Naoki , Kamibayashi Junya , Matsuoka Motoki , Waki Keita , Kawaguchi Ryuji , Kimura Fuminori 
Published: December 2024

Abstract

Background
Recently, there have been an increasing number of reports on the association between inflammatory markers and the prognosis of malignant tumors. However, the current inflammatory indicators have limited accuracy. We aimed to develop a new scoring system for predicting endometrial cancer recurrence using inflammatory markers, tumor markers, and histological diagnoses.
Methods
Patients with primary, previously untreated, and suspected endometrial cancer who underwent surgery at the Nara Medical University Hospital between January 2007 and December 2020 were included and followed up until March 2024. Items were divided into positive and negative using scores based on cutoff values and placed into the new scoring system, the endometrial tumor-related (ETR) score.
Results
We found that positive postoperative histological examination of lymph node metastasis and myometrial invasion, high levels of carcinoembryonic antigen and D-dimer in preoperative blood tests, and a large difference in preoperative and postoperative white blood cell counts were significantly associated with recurrence. The prediction of recurrence sensitivity and specificity using the ETR score were superior to those using the International Federation of Gynecology and Obstetrics staging system, which is considered the best prognostic factor for survival.
Conclusions
The ETR score is a significant prognostic marker of recurrence in patients who have undergone lymphadenectomy, with complete surgical tumor removal.
Quantifying the Diagnostic Odyssey Burden Among Persons with Inborn Errors of Immunity
Authors: Nikzad Sarina , Johnson Rebekah , Scalchunes Chrisopher , Rider Nicholas L. 
Published: December 2024

Abstract

Purpose
Patients with inborn errors of immunity (IEI) have lifelong health complications including severe infections and physical impairments. Previous studies show that a patient’s perception of their health is an important predictor of health outcomes. The purpose of our study is to understand factors related to patient reported overall health status.
Methods
We used data from the Immunodeficiency Foundation (IDF) 2017 National Patient Survey and analyzed factors which correlated with the reported health status (RHS). Among a cohort of 1139 self-reported IEI patients, we identified age at the time of diagnosis, time gap between symptom onset and diagnosis, number of physicians seen, and whether the diagnosis was made in the first 5 years of life as significant. We used a two-tailed t-test, single-factor ANOVA, and Tukey-Kramer post-hoc test to analyze the statistical significance in the observed difference.
Results
Patients who received a diagnosis before the age of 12 had a significantly better RHS (n = 207 pre-12a vs. n = 900 post-12a; p < 0.0001). Patients who received a diagnosis within 10 years of symptom onset showed improved RHS (n = 413 pre-10s vs. n = 524 post-10s; p = < 0.0001). Among patients who had symptom onset within the first 5 years of life, those who received a diagnosis had a significantly improved RHS (n = 275 undiagnosed pre-5a vs. n = 108 diagnosed pre-5a; p < 0.0001). Finally, RHS was significantly impacted by the number of physicians they saw (n = 252 low vs. n = 886 high; p = < 0.0001).
Conclusion
These findings shed light upon critical factors which impact IEI patients’ RHS.
Routine cold storage leads to hyperacute graft loss in pig-to-primate kidney xenotransplantation; hypothermic machine perfusion may be preferred preservation modality in xenotransplantation
Authors: Yamada Kazuhiko , Hisadome Yu , Eisenson Daniel , Chen WeiLi , Schulick Alex , Santillan Michelle , Luo Adam , Casella Kelly , Gu Du , Sekijima Mitsuhiro , Sahara Hisashi , Warren Daniel , Cameron Andrew , Iwase Hayato , Shenderov Eugene 
Published: December 2024

Abstract

Xenotransplantation (XTx) is an increasingly realistic solution to the organ shortage. Clinical XTx may require off-site procurement in a designated pathogen free (DPF) facility necessitating a period of cold ischemic time during transportation. This study evaluates the impact of different kidney preservation strategies on early graft function in pig-to-baboon XTx in a series of eight cases of pig-to-baboon xenotransplantation performed after five hours of cold ischemic time and compares these results to six cases of pig-to-baboon xenotransplantation performed with minimal ischemic time. Our data indicates that porcine kidneys appear to be particularly sensitive to IRI after cold preservation, especially across xenogeneic barriers, and routine static cold storage leads to hyperacute graft loss even in recipients with low levels of preformed antibodies. Hypothermic machine perfusion minimizes IRI and may prevent early xenograft loss.
Lenalidomide in combination with Rituximab, Dexamethasone, High-dose ARA-C and Cisplatinum as Salvage Therapy in Refractory or Relapsed Aggressive B-cell Non-Hodgkin-Lymphoma - An open-label, multicentre phase I/II study (DSHNHL-R6)
Authors: Fuhrmann Stephan , Nickelsen Maike , Hasenkamp Justin , Hüttmann Andreas , Dreyling Martin , Kiehl Michael , Salwender Hans , Placzek Marius , Schmitz Norbert , Glass Bertram 
Published: December 2024

Abstract

Treatment of relapsed and refractory large cell B-NHL (LBCL) is still an unmet medical need. Platinum-containing salvage immunotherapies achieve remission rates of 40-60 %. The phase I/II DSHNHL-R6 trial sought to investigate feasibility, safety and efficacy of R-DHAP plus lenalidomide in patients with first or subsequent relapse of LBCL.
35 patients were enrolled in the trial and 33 could be analyzed (ITT). Lenalidomide dose was stepwise increased if no dose-limiting toxicities were observed.
MTD for lenalidomide in combination with R-DHAP was 15 mg administered on days 1-7 of each cycle. The overall response rates (ORR; defined as complete, unconfirmed complete or partial remission) and complete response rates (CR) rates were 62.5% and 29.0% for the ITT-population and 81.3% and 50.0% in the patients treated as per protocol (PP). With a median follow-up of 13.9 months, the median OS was 21.2 months and PFS for the ITT and PP-population were 10.7 and 18.9 months respectively. No treatment related deaths were observed. Haematologic adverse events (77% grade 3-4) were common.
Combining Lenalidomide with R-DHAP is an effective and tolerable salvage therapy for patients with LBCL.(registered at www.clinicaltrialsregister.eu; EudraCT number: 2009-010824-25; Start Date: 2010-04-12)
Deep learning algorithms enable MRI-based scapular morphology analysis with values comparable to CT-based assessments
Authors: Hess Hanspeter , Oswald Alexandra , Rojas J Tomás , Lädermann Alexandre , Zumstein Matthias A. , Gerber Kate 
Published: December 2024

Abstract

Scapular morphological attributes show promise as prognostic indicators of retear following rotator cuff repair. Current evaluation techniques using single-slice magnetic-resonance imaging (MRI) are, however, prone to error, while more accurate computed tomography (CT)-based three-dimensional techniques, are limited by cost and radiation exposure. In this study we propose deep learning-based methods that enable automatic scapular morphological analysis from diagnostic MRI despite the anisotropic resolution and reduced field of view, compared to CT. A deep learning-based segmentation network was trained with paired CT derived scapula segmentations. An algorithm to fuse multi-plane segmentations was developed to generated high-resolution 3D models of the scapula on which morphological landmark- and axes were predicted using a second deep learning network for morphological analysis. Using the proposed methods, the critical shoulder angle, glenoid inclination and version were measured from MRI with accuracies of -1.3 ± 1.7 degrees, 1.3 ± 2.1 degree, and − 1.4 ± 3.4 degrees respectively, compared to CT. Inter-class correlation between MRI and CT derived metrics were substantial for the glenoid version and almost perfect for the other metrics. This study demonstrates how deep learning can overcome reduced resolution, bone border contrast and field of view, to enable 3D scapular morphology analysis on MRI.