bluuebunny/crossref_metadata_2025_split huggingface dataset:
A candidate probiotic strain of Enterococcus faecium from the intestine of the crucian carp Carassius auratus
Authors: Mao Qing , Sun Xueliang , Sun Jingfeng , Zhang Feng , Lv Aijun , Hu Xiucai , Guo Yongjun 
Published: February 2020

AbstractIn the present study, a Gram-positive bacterium was isolated from the intestine of healthy crucian carp Carassius auratus and named strain R8. It was initially identified as Enterococcus faecium according to its morphological, physiological and biochemical characteristics. Further identification by using 16S rRNA gene sequence analysis confirmed the R8 strain (Genbank accession no. MF928076) as E. faecium. Challenge and hemolysis experiments showed that the E. faecium R8 strain had no toxicity to the crucian carp. Bacteriostatic experiment showed that this isolate obviously inhibited the growth of Aeromonas veronii and Staphylococcus haemolyticus. The proliferation of E. faecium R8 strain occurred after exposure to various growth conditions such as at pH values from 2.0 to 4.0 for 8 h, bile concentrations from 0.2 to 1.2% and high temperature of 80 °C. This bacterial strain grew best under the condition of 37 °C, pH 7.0 and salinity 30 ppt, and its growth curve exhibited four distinct phases. These results showed that the E. faecium R8 strain had potential probiotic characteristics and could be used as a candidate strain for aquatic probiotics.
Insights into superoxide dismutase 3 in regulating biological and functional properties of mesenchymal stem cells
Authors: Sah Shyam Kishor , Agrahari Gaurav , Kim Tae-Yoon 
Published: February 2020

AbstractMesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent stem cells have either ethical issues or concerns regarding the formation of teratomas, introduction of mutations into genome during prolonged culture, respectively which limit their uses in clinical settings. On the other hand, MSCs also encounter certain limitation of circumscribed survival and reduced immunomodulatory potential during transplantation. Plethora of research is undergoing to improve the efficacy of MSCs during therapy. Several compounds and novel techniques have been employed to increase the therapeutic potency of MSCs. MSCs secreted superoxide dismutase 3 (SOD3) may be the mechanism for exhibiting direct antioxidant activities by MSCs. SOD3 is a well known antioxidant enzyme and recently known to possess immunomodulatory properties. Along with superoxide scavenging property, SOD3 also displays anti-angiogenic, anti-chemotactic and anti-inflammatory functions in both enzymatic and non-enzymatic manners. In this review, we summarize the emerging role of SOD3 secreted from MSCs and SOD3’s effects during cell-based therapy.
Leveraging lessons learned to prevent future disasters—insights from the 2013 Colombia-US binational exchange
Authors: Driedger Carolyn , Calvache Marta , Cortés Gloria Patricia , Ewert John , Montoya Jacqueline , Lockhart Andy , Allen Robert , Banks Daniel , Beason Scott , Bocanegra Harold Trujillo , Burkhart Frances , Bustad Kyle , Gallego Jaime Andres , Gibson Zane , Giraldo Felix Ricardo , Gutierrez Cesar , Quintero Jorge Ivan , Rodríguez Eduardo , Schelling John , Scott Marci 
Published: February 2020

AbstractIn 2013, scientists implemented a binational exchange for emergency planners and responders in communities near Nevado del Ruiz in Colombia and volcanoes of the Cascade Range of the United States (US). This program was designed to promote understanding of volcanic disasters and effective mitigation options, motivate participants to strengthen emergency planning efforts, and promote trust-building among participants. The 2013 Binational Exchange was funded by the Volcano Disaster Assistance Program (VDAP), a joint U.S. Geological Survey (USGS)—U.S. Agency for International Development (USAID) program.During a week-long visit to Colombian emergency response agencies, Nevado del Ruiz, and lahar-destroyed ruins of the city of Armero and the region of Viejo Rio Claro, US participants became familiar with Colombian counterparts who have had recent and frequent experiences addressing volcanic crises. Aging survivors and authorities of the Nevado del Ruiz catastrophe of 1985 gave participants first-hand accounts, and ideas for improved preparedness and response. While in the US, Colombian participants observed emergency response capabilities and facilities, and received training in systems of incident command. Colombians made presentations to the US public and officials about the similarities of lahar risks in both nations.This article describes the 2013 Binational Exchange as an experiential learning event and uses results of post-exchange discussions and interviews as evidence of steps achieved within the learning process. Six years hence, this article provides examples of progress with volcano hazards mitigation in both nations. The article offers the binational exchange model as an effective tool that employs both experiential learning and socialization of participants to create a highly motivating and effective learning environment.
Global existence and blow-up analysis for parabolic equations with nonlocal source and nonlinear boundary conditions
Authors: Kou Wei , Ding Juntang 
Published: February 2020

AbstractWe investigate the following nonlinear parabolic equations with nonlocal source and nonlinear boundary conditions:$$ \textstyle\begin{cases} (g(u) )_{t} =\sum_{i,j=1}^{N} (a^{ij}(x)u_{x_{i}} ) _{x_{j}}+\gamma _{1}u^{m} (\int _{D} u^{l}{\,\mathrm{d}}x ) ^{p}-\gamma _{2}u^{r}& \mbox{in } D\times (0,t^{*}), \\ \sum_{i,j=1}^{N}a^{ij}(x)u_{x_{i}}\nu _{j}=h(u) & \mbox{on } \partial D\times (0,t^{*}), \\ u(x,0)=u_{0}(x)\geq 0 &\mbox{in } \overline{D}, \end{cases} $${(g(u))t=∑i,j=1N(aij(x)uxi)xj+γ1um(∫Duldx)p−γ2urin D×(0,t∗),∑i,j=1Naij(x)uxiνj=h(u)on ∂D×(0,t∗),u(x,0)=u0(x)≥0in D‾,wherepand$\gamma _{1}$γ1are some nonnegative constants,m,l,$\gamma _{2}$γ2, andrare some positive constants,$D\subset \mathbb{R}^{N}$D⊂RN($N\geq 2$N≥2) is a bounded convex region with smooth boundary∂D. By making use of differential inequality technique and the embedding theorems in Sobolev spaces and constructing some auxiliary functions, we obtain a criterion to guarantee the global existence of the solution and a criterion to ensure that the solution blows up in finite time. Furthermore, an upper bound and a lower bound for the blow-up time are obtained. Finally, some examples are given to illustrate the results in this paper.
Retraction Note: Fixed point theorems and explicit estimates for convergence rates of continuous time Markov chains
Authors: Yan Zhenhai , Yan Guojun , Miyamoto Ikudol 
Published: February 2020

The Editors-in-Chief have retracted this article [1] because it showed evidence of peer review manipulation. In addition, the identity of the corresponding author could not be verified: Nagoya University have confirmed that Ikudol Miyamato has not been affiliated with their Graduate School of Mathematics.The authors have not responded to any correspondence regarding this retraction.
Microstructure evolution in deformed polycrystals predicted by a diffuse interface Cosserat approach
Authors: Ask Anna , Forest Samuel , Appolaire Benoît , Ammar Kais 
Published: February 2020

AbstractFormulating appropriate simulation models that capture the microstructure evolution at the mesoscale in metals undergoing thermomechanical treatments is a formidable task. In this work, an approach combining higher-order dislocation density based crystal plasticity with a phase-field model is used to predict microstructure evolution in deformed polycrystals. This approach allows to model the heterogeneous reorientation of the crystal lattice due to viscoplastic deformation and the reorientation due to migrating grain boundaries. The model is used to study the effect of strain localization in subgrain boundary formation and grain boundary migration due to stored dislocation densities. It is demonstrated that both these phenomena are inherently captured by the coupled approach.
Evaluation of the national implementation of the VA Diffusion of Excellence Initiative on Advance Care Planning via Group Visits: protocol for a quality improvement evaluation
Authors: Matthieu Monica M. , Ounpraseuth Songthip T. , Painter Jacob , Waliski Angie , Williams James “ Silas” , Hu Bo , Smith Robin , Garner Kimberly K. 
Published: February 2020

AbstractBackgroundTraditionally, system leaders, service line managers, researchers, and program evaluators hire specifically dedicated implementation staff to ensure that a healthcare quality improvement effort can “go to scale.” However, little is known about the impact of hiring dedicated staff and whether funded positions, amid a host of other delivered implementation strategies, are the main difference among sites with and without funding used to execute the program, on implementation effectiveness and cost outcomes.Methods/designIn this mixed methods program evaluation, we will determine the impact of funding staff positions to implement, sustain, and spread a program, Advance Care Planning (ACP) via Group Visits (ACP-GV), nationally across the entire United States Department of Veterans Affairs (VA) healthcare system. In ACP-GV, veterans, their families, and trained clinical staff with expertise in ACP meet in a group setting to engage in discussions about ACP and the benefits to veterans and their trusted others of having an advance directive (AD) in place. To determine the impact of the ACP-GV National Program, we will use a propensity score-matched control design to compare ACP-GV and non-ACP-GV sites on the proportion of ACP discussions in VHA facilities. To account for variation in funding status, we will document and compare funded and unfunded sites on the effectiveness of implementation strategies (individual and combinations) used by sites in the National Program on ACP discussion and AD completion rates across the VHA. In order to determine the fiscal impact of the National Program and to help inform future dissemination across VHA, we will use a budget impact analysis. Finally, we will purposively select, recruit, and interview key stakeholders, who are clinicians and clinical managers in the VHA who offer ACP discussions to veterans, to identify the characteristics of high-performing (e.g., high rates or sustainers) and innovative sites (e.g., unique local program design or implementation of ACP) to inform sustainability and further spread.DiscussionAs an observational evaluation, this protocol will contribute to our understanding of implementation science and practice by examining the natural variation in implementation and spread of ACP-GV with or without funded staff positions.
Critical psychiatry: an embarrassing hangover from the 1970s?
Authors: Double Duncan B. 
Published: February 2020

SummaryCritical psychiatry is associated with anti-psychiatry and may therefore seem to be an embarrassing hangover from the 1970s. However, its essential position that functional mental illness should not be reduced to brain disease overlaps with historical debates in psychiatry more than is commonly appreciated. Three examples of non-reductive approaches, like critical psychiatry, in the history of psychiatry are considered.
Comparing drug regimens for clearance of malaria parasites in asymptomatic adults using PCR in Kilifi County, Kenya: an open-label randomised controlled clinical trial (MalPaC)
Authors: Khaemba Emma Nelima , Ogwang Caroline , Kinyanjui Sam , Muindi John Mutiso , Koske Joseph Kipsigei , Kimani Domtila , Ngoi Joyce , Mwacharo Jedidah , Shangala Jimmy , Njuguna Patricia , Mutinda Dennis , Nyatichi Emily , Peshu Judy , Mutinda Brian , Ndungu Francis M. , Farnert Anna , Bashraheil Mahfudh M. , Bejon Philip , Kapulu Melissa C. 
Published: February 2020

Background: To restrict trial endpoints to infections acquired after vaccination in Phase IIb trials of candidate malaria vaccines, participants are treated with anti-malarial drugs to clear existing infections. Anti-malarial drugs with a long half-life may inhibit the acquisition of new infections. This study evaluated the effects of three anti-malarial drug regimens on the clearance of existing infections and acquisition of new infections. Methods: An open-label randomised controlled trial (MalPaC) was conducted between November 2013 and February 2014. Ninety adults were randomised 1:1:1 to receive one of three treatments: atovaquone/proguanil and artesunate (AP+AS); artesunate (AS); or sulphadoxine-pyrimethamine, artesunate, and primaquine (SP+AS+PQ). Parasite monitoring was determined over 84-day follow-up by assessing Plasmodium falciparum positivity by 18s qPCR, live and sexual stage parasites by RT-PCR, and recrudescence of infections by msp2 genotyping. Results: At enrolment, parasite prevalence by qPCR was 44% (40/90, day 0), which fell to 10% (9/90, day 16), then rose to almost the initial rates by day 84 (39%, 35/90). Individuals treated with AS and SP+AS+PQ were more likely to have higher qPCR positive rates compared to participants treated with AP+AS in the immediate post-treatment phase (days 16-28) (OR=7.7 [95%CI 4.6-12.8] p<0.0005 and OR=4.2 [95%CI 2.6-6.8] p<0.0005, respectively). In the immediate post-treatment phase, qPCR positivity was less likely associated with evidence of live parasites and gametocytaemia. Prevalence of “old”, “new” or “undetectable” infections did not differ significantly over time or drug regimen. However, participants on the AP+AS drug regimen were less likely to have parasite infection recrudescence compared to participants treated with AS and SP+AS+PQ. Conclusion: Falciparum DNA remained detectable by PCR post-treatment with incomplete parasite clearance regardless of drug regimen. Though AP+AS drug regimen may also have partially suppressed the acquisition of new infections during post-treatment follow-up. Trial registration: Pan African Clinical Trials Registry, 22nd of August 2013, PACTR201309000625311.
Pregnant Women's Reasons for and Experiences of Visiting Antiabortion Pregnancy Resource Centers
Authors: Kimport Katrina 
Published: February 2020

CONTEXTThe primary mission of pregnancy resource centers is to dissuade women from choosing abortion. Reproductive health and rights advocates have asserted that these centers interfere in abortion decision making. However, the reasons pregnant women go to such centers and what they experience while there have not been examined.METHODSBetween June 2015 and June 2017, in‐depth, semistructured phone interviews were conducted with 21 pregnant women who had presented at prenatal care clinics in southern Louisiana and Baltimore, Maryland, and who had visited a pregnancy resource center. Topics covered in the interviews included reasons for visiting a center and the experience of the visit. Transcripts were analyzed first thematically and then using grounded theory.RESULTSMost of the women were low income and had not been considering abortion when they visited a pregnancy resource center. Respondents reported that they had gone to these centers for pregnancy‐related services, material goods and social support. They chose these centers because the resources were free, and they were largely satisfied with their experiences. Nonetheless, their receipt of services and goods was limited and often contingent on participation in the centers’ activities.CONCLUSIONSPregnancy resource centers play a role in meeting the acute material and social needs of low‐income pregnant women. However, the constraints on the resources the centers offer mean that this support cannot be part of a reliable system of care. Advocates and policymakers should take a nuanced approach to regulating these centers and consider the reasons women visit them, especially low‐income women.
Risks associated with Logistics 4.0 and their minimization using Blockchain
Authors: Kodym Oldřich , Kubáč Lukáš , Kavka Libor 
Published: February 2020

Abstract
Currently we are saying that we are at the dawn of the fourth revolution, which is marked by using cyberphysical systems and the Internet of Things. This is marked as Industry 4.0 (I4.0). With Industry 4.0 is also closely linked concept Logistics 4.0. The highly dynamic and uncertain logistic markets and huge logistic networks require new methods, products and services. The concept of the Internet of Things and Services (IoT&S), Big Data/ Data Mining (DM), cloud computing, 3D printing, Blockchain and cyber physical system (CPS) etc. seem to be the probable technical solution for that. However, associated risks hamper its implementation and lack a comprehensive overview. In response, the paper proposes a framework of risks in the context of Logistics 4.0. They are here economic risks, that are associated e.g. with high or false investments. From a social perspective, risks the job losses, are considered too. Additionally, risks can be associated with technical risks, e.g. technical integration, information technology (IT)-related risks such as data security, and legal and political risks, such as for instance unsolved legal clarity in terms of data possession. It is therefore necessary to know the potential risks in the implementation process.
A Picture-Book Based Corpus Study on the Acquisition of wh-words in Japanese
Authors: Ito Natsue , Tamaoka Katsuo , Mansbridge Michael Patrick 
Published: February 2020

Abstract
Clancy (1989. Form and function in the acquisition of Korean wh-questions. Journal of Child Language, 16(2), 323–47) claims that the developmental order of wh-questions in first language acquisition follows the order: what = where<who<how=why<when. Forner (1979. The mother as LAD: interaction between order and frequency of parental input and child production. In A. Hastings & F. R. Eckman (Eds.), Studies in first and second language acquisition (pp. 17–44). New York, NY: Newbury House Publishers) further argues that a mother’s order of introducing wh-questions might be influenced by her assumption of a child’s cognitive development. Similarly, the target age for picture books might also reflect an adult’s assumption of the child’s cognitive development. Accordingly, this study investigates a Japanese picture book corpus to determine whether the order of appearance for wh-words mirrors that of Clancy’s developmental order. As a result, the appearance of Japanese wh-words in the picture books were similar to Clancy’s (1989. Form and function in the acquisition of Korean wh-questions. Journal of Child Language, 16(2), 323–47) order except for the question dou ‘how’. Because dou and the English ‘how’ have different ranges of meaning, the data were reanalyzed which resulted in an order more similar to Clancy’s. These results suggest that the target age of picture books reflect the adult’s assumption of a child’s cognitive development. Picture books might also influence a caregivers’ order of introducing wh-words. In conclusion, this study implies external social factor such as picture books, together with other factors, might influence the children’s wh-developmental order.
Dative Alternation in Nigerian English: A Corpus-based Approach
Authors: Akinlotan Mayowa , Akinmade Akande 
Published: February 2020

Abstract
Dative alternation is that sort of construction which requires a choice from two available choices; the double object (DOC) (i. e. Please give Mary the book) and the preposition construction (TOC) (i. e. Please give the book to Mary). Empirical evidence detailing the characteristics and motivations of dative choices in different varieties have been put forward in the literature. Albeit, nothing is known about the nature and motivations of this phenomenon in Nigerian variety of English, an important source of empirical evidence in the English-world-wide paradigm. With 739 sentences extracted from International Corpus of English, we examined the effects of 16 predictors on this construction in the Nigerian variety; showing how the behavior of these predictors compares with findings reported in other varieties. Among other findings, we found that overall Nigerian variety is closer to American variety than Indian variety, and pronominality as the strongest predictor, outweighing register as a reputable predictor.
Die Sprachen der Neuen Welt in Belegen deutscher Sprachdenker des 17. und 18. Jahrhunderts
Authors: Roelcke Thorsten 
Published: February 2020

Zusammenfassung
In dem Heidelberger Forschungsprojekt zur deutschen Sprachreflexion des Barock und der Aufklärung wurden einige Bemerkungen zu den Sprachen der Neuen Welt gefunden; diese werden hier gezeigt und kurz erläutert.
Dynamical Study of Competition Cournot-like Duopoly Games Incorporating Fractional Order Derivatives and Seasonal Influences
Authors: Al-khedhairi Abdulrahman 
Published: February 2020

Abstract
Cournot’s game is one of the most distinguished and influential economic models. However, the classical integer order derivatives utilized in Cournot’s game lack the efficiency to simulate the significant memory characteristics observed in many economic systems. This work aims at introducing a dynamical study of a more realistic proposed competition Cournot-like duopoly game having fractional order derivatives. Sufficient conditions for existence and uniqueness of the new model’s solution are obtained. The existence and local stability analysis of Nash equilibrium points along with other equilibrium points are examined. Some aspects of global stability analysis are treated. More significantly, the effects of seasonal periodic perturbations of parameters values are also explored. The multiscale fuzzy entropy measurements for complexity are employed for this case. Numerical simulations are presented in order to verify the analytical results. It is observed that the time-varying parameters induce very complicated dynamics in perturbed Cournot duopoly game compared with the unperturbed game.