bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effectiveness of in-service training program of Amhara Public Health Institute Dessie Branch, Northeast Ethiopia: a concurrent nested mixed quantitative/qualitative facility based cross sectional study
Authors: Husen Seid Legesse , Marefiaw Tefera Alemu , Hailie Mulugeta Tasew , Ayalew Birtukan Shiferaw , Reta Zerfie Tadesse , Desalew Semagn Amare , Temesgen Minwuyelet Maru 
Published: August 2020

Abstract
Background

In-service training programs should be evaluated and modified regularly to provide quality health services. However, in Ethiopia, there is no published evidence about its effectiveness. Therefore, we evaluated the effectiveness of in-service training program of Amhara Public Health Institute Dessie Branch (APHI) using the Kirkpatrick model.
Methods

In October 2019, a concurrent nested mixed quantitative/qualitative, facility-based cross-sectional study was conducted among 107 stakeholders from 22 randomly selected east Amhara government health facilities. The qualitative part also involved all this key stakeholder interviews. Data was collected using a semi-structured questionnaire through face to face interview. Epi data manager and Microsoft Excel 2016 software’s were used for data entry and analysis respectively. The major qualitative findings were narrated and summarized based on thematic areas to supplement the quantitative findings.
Results

A total of 107 laboratory professionals working in 22 health facilities were interviewed with a response rate of 97.3%. At reaction level, 82.1% of participants strongly agreed/agreed with the course structure, training contents and learning tools. Likewise, 85.4% of them strongly agreed/agreed on trainer's knowledge and their communication skills. Besides, 93.1% of them stated an improvement in knowledge and skills after attending training. Yet, only 65.6% of participants transferred their knowledge and skills in to practice. Regarding the training set ups and environment, 45.1% of the respondents strongly disagreed/disagreed with the training hall, toilet, café, financial process, accommodation perdiem and, tea & snacks.
Conclusion and recommendations:

Generally speaking, the laboratory in-service training program of APHI was more or less effective. Our finding suggests regular monitoring and evaluation of training events based on a standard set of performance indicators. Furthermore, the institute is mandated to create a conducive learning environment and well established training set ups for trainees.
Early Monitoring of Infliximab Serum Trough Levels Predicts Long-Term Therapy Failure in Patients With Axial Spondyloarthritis
Authors: Feito Ana Martínez , Navarro-Compán Victoria , Hernández-Breijo Borja , Olariaga-Mérida Eva , Peiteado Diana , Villalba Alejandro , Nuño Laura , Monjo Irene , Diego Cristina , Pascual-Salcedo Dora , Nozal Pilar , Balsa Alejandro , Plasencia-Rodriguez Chamaida 
Published: August 2020

Abstract
Background: The aim of our study is to evaluate whether serum infliximab trough levels (ITL) during the early stages of treatment are predictive of long-term clinical failure in patients with axial spondyloarthritis (axSpA).Methods: Longitudinal observational study involving 81 patients with axSpA recruited from the SpA-Paz cohort and monitored during infliximab therapy. Serum ITL were measured at baseline, week 2 (W2), W6 and W12 of treatment. Disease activity was assessed by the Ankylosing Spondylitis Disease Activity Score (ASDAS) at baseline, W24 and W54, and every 6 months thereafter until therapy failure. Non-clinically important improvement was defined by ΔASDAS<1.1. The association between serum ITL levels at W12 and clinical outcomes (non-improvement at W52, drug survival and drop-out due to secondary inefficacy) was investigated through logistic regression models and Kaplan Meier curves. Receiver operating characteristic (ROC) curves were employed to determine the best cut-off for serum ITL. Results: Out of the 81 patients, 45 (56%) did not achieve clinical improvement at W52. These patients had lower serum ITL at W12 compared to those who improved: ITL [median (IQR)]: 4.1(0.9-8.3) µg/ml vs 7.1(4.3-11.3)µg/ml, respectively; p=0.007). A cut-off of ITL<6.7µg/mL at W12 was significantly associated with: i) not achieving clinical improvement at W52 (OR: 2.3; 95%CI: 1.3-3.9); ii) shorter drug survival (5.0 years (95% CI: 3.8-6.2) vs 7.6 years (95% CI: 4.8-6.9); p=0.04); and iii) higher drop-out rates due to secondary inefficacy (OR: 3.5; 95%CI: 1.2-10.2). Conclusions: Serum ITL<6.7 µg/mL at W12 were associated with long-term clinical failure in patients with axSpA, especially due to secondary inefficacy.
Melatonin Dependent Modulation in microRNAs Relative Expression Pattern and Levels of cfDNA in Mature Oocytes of Unexplained Infertile Patients.
Authors: Khan Haroon Latif , bhatti Shahzad , abbas Sana , Kaloglu Celal , Qurat-ul-ain Syeda , Khan Yousaf Latif , Hassan Zahira , Aydin Hikmet Hakan , Turhan Nilgün Öztürk , Bousnane Nour El Houda , Yildiz Aysegul , Saruhashi Isadora 
Published: August 2020

Abstract
BackgroundIntrafollicular melatonin maintains the DNA integrity of granulosa cells and protects them against apoptosis. This ubiquitous indoleamine compound serves as a potent free radical scavenger. It reduces oxidative stress and modulates DNA damage response, which improves oocyte's quality with a higher fertilization rate.Methods:This prospective study was designed to investigate the antioxidant property of intrafollicular melatonin and its impact on IVF outcome parameters by exploring the relative expression of five microRNAs (miR-663b, miR-320a, miR-766-3p, miR-132-3p, and miR-16-5p) and levels of cfDNA by real-time PCR in unexplained infertile patients. We collected 425 follicular fluid (ff) samples containing mature oocytes from 295 patients undergoing IVF. Results:Patients were sub-grouped based on intrafollicular melatonin concentration (Group A; ≤ 30 pg/mL, Group B; >70 to ≤110 pg/mL), Group C; >111 to ≤ 385 pg/mL). Our results showed that patients with ≤ 30 pg/mL intrafollicular melatonin levels have a significantly higher cfDNA levels and lower relative expression of miR-663b, miR-320a, miR-766-3p, miR-132-3p, and miR-16-5p compared to other subgroups (p<0.001). Similarly, they have a low fertilization rate and a reduced number of high-quality day 3 embryos. For the probability of obtaining a good quality embryo, miRNAs had AUC value of 0.89 [95% Cl; 0.71; 0.93] with 87% sensitivity and 83 % specificity (p = 0.001), whereas cfDNA have AUC value 0.76 [cut-off points, 95% Cl: 0.61, 0.67; 0.85] along with 82.4 % senstivity and 66.7 % specificity.Conclusion:Conclusively, our study provided evidence that melatonin's antioxidant capability significantly impacts cfDNA concentration and miRNAs relative expression profile in the follicular microenvironment for optimal oocyte development and embryo quality. Therefore, it may be a potent non-invasive diagnostic tool to select high-quality day 3 embryos with such promise.
New Insight Into Rumen Methanogen Function: a Barrier Blocking Trimethylamine From Entering the Host Body
Authors: Zhou Yang , Wei Jin , Xie Fei , Mao Shengyong , Cheng Yanfen , Zhu Weiyun 
Published: August 2020

Abstract
Background: Trimethylamine (TMA) is the precursor of trimethylamine N-oxide (TMAO), which has been known to promote human cardiovascular disease. Methanomassiliicoccales (Mmc), TMA-utilizing methanogens, may function as a TMA barrier for the host in the rumen. This study aimed to investigate the role of Mmc in rumen TMA elimination and the effect of choline addition in the diet on the rumen TMA and TMAO concentrations in the plasma and milk of dairy cows.Results: Three experiments, 2 rumen in vitro fermentation trials and 1 dairy cow in vivo trial, were conducted. Four groups were set in Experiment 1: control, nitroglycerin (NG, a methanogen inhibitor), TMA (0.69 mg/mL), and TMA + NG. The methanogenic activity was completely inhibited in the NG group, and no methane production was observed in the NG and TMA + NG groups. The TMA content hardly reduced in the TMA + NG group (0.66 mg/mL) after 2 d of incubation; in contrast, it reduced by 47.2% in the TMA group. Methanogen 16S rRNA gene sequencing showed that the relative abundance of Mmc increased in the TMA group (P = 0.005), which was confirmed by real-time polymerase chain reaction testing. Two taxa (Group 9 sp. ISO4-G1 and Group 10 sp.) at the species level mainly contributed to the increase in the relative abundance of Mmc. Four groups were set in Experiment 2: control, NG, choline (choline chloride, 1.0 mg/mL), and choline + NG. Choline was completely degraded in 24 h, and the TMA content reached the peak point in the fermentation culture. The TMA content in the choline + NG group did not reduce after the occurrence of the peak point. In contrast, the TMA content in the choline group started to decrease after 24 h, corresponding to the rapid increase in methane production. Eight mid-lactating, rumen-fistulated Holstein cows were randomly assigned to the control (n = 4) or choline (n = 4) group in Experiment 3: In the choline group, the cows were gradually supplemented with 100–250 g/(cow·d) of choline chloride over 4 weeks. In the choline group, TMA accumulated in the rumen fluid, and the abundance of Mmc 16S rRNA gene and choline-degrading bacterial cutC gene increased in the rumen content (P < 0.050). The TMAO content in the plasma and milk of the dairy cows was approximately 10 times higher in the choline group than in the control at day 28.Conclusion: Rumen Mmc functioned as a TMA barrier for the host. The increase in dietary choline caused more TMA to enter the host body, resulting in higher TMAO deposition in the milk of the dairy cows. It should be noted that TMAO-rich milk might degrade food safety. Moreover, it should be discreet to mitigate rumen methane emission by inhibiting the rumen methanogen activities, which might destroy the rumen TMA barrier.
Interaction between amorolfine and voriconazole against Fusarium species
Authors: Liang Pin , Song Jiquan , Liu Qin 
Published: August 2020

Abstract
Background: Fusarium species are environmentally ubiquitous fungi capable of causing diverse superficial, locally invasive, or disseminated infections, making them important pathogens. Compared with antibacterial drugs, the types of antifungal drugs are still limited, and the adverse reactions are significant. Therefore, novel treatments against Fusarium spp. are an urgent need.Results: Here we investigated the interaction of amorolfine combined with voriconazole on Fusarium spp. Our study demonstrated that amorolfine in combination with voriconazole could inhibited the Fusarium spp. significantly. Galleria mellonella was also used as a model to show the interaction of the two-drug combination in vivo against Fusarium spp.; larval survival rates were significantly higher after treatment with the amorolfine-voriconazole combination compared to the monotherapy group.Conclusions: This study is the first to demonstrate that voriconazole combined with amorolfine has a synergistic effect against Fusarium spp. infection and may be an effective method for antifungal therapy.
Lahares secundarios en el volcán Popocatépetl: El lahar Nexpayantla del 4 de febrero, 2010
Authors: Zaragoza Gabriela , Caballero-García Lizeth , Capra Lucia , Nieto-Torres Amiel 
Published: August 2020

Los lahares secundarios representan una de las mayores amenazas en volcanes activos o en estado de quietud, por lo tanto, es importante estimar la frecuencia, distribución y los mecanismos disparadores en diferentes volcanes para establecer escenarios de peligro.
En este trabajo se analizó el lahar ocurrido el día 4 de febrero del 2010, en la barranca Nexpayantla, ubicada en el sector NW del volcán Popocatépetl. Para ello, se realizó un estudio geomorfológico y textural del depósito, así como de la precipitación y de imágenes de satélite tipo ASTER para delimitar el área de inundación y el mecanismo disparador. Los datos mostraron que este evento se generó por una precipitación de 100 mm/día e inició como una corriente fluvial, que se transformó en un flujo de escombros y finalizó como una corriente diluida. Su transformación, de corriente fluvial a flujo de escombros, se debió a la incorporación de sedimentos por erosión laminar y procesos de remoción en masa que ocurrieron en la barranca, asociados al mismo evento de precipitación. En contraste, su dilución a una corriente fluvial fue por la rápida sedimentación relacionada con cambios en la geometría del cauce, el alto contenido de troncos de árboles y el bajo contenido de material fino. La reproducción del evento mediante simulaciones numéricas permitió calcular que su profundidad pudo alcanzar 1.7 m. Al comparar la distribución del depósito en campo y del lahar en las imágenes de satélite, se observó que el depósito representa sólo el 68 % del área total de inundación del evento. Asimismo, el análisis de la lluvia indicó que una precipitación de igual magnitud a la que disparó el lahar Nexpayantla, tiene un periodo de retorno de 27 años. Finalmente, trabajos enfocados en la caracterización de lahares secundarios en el volcán Popocatépetl permitirán establecer escenarios que incluyan casos como el aquí estudiado.
RANCANG BANGUN APLIKASI KATALOG KERJA PRAKTEK DAN TUGAS AKHIR BERBASIS ANDROID
Authors: Novita Rice , Zahri Herman 
Published: August 2020

Kerja Praktek dan Tugas Akhir merupakan karya ilmiah yang disusun oleh setiap mahasiswa yang ingin menyelesaikan jenjang pendidikan strata 1. Dalam membuat karya ilmiah berupa laporan kerja praktek dan tugas akhir, tentunya membutuhkan banyak referensi, baik dari buku maupun penelitian penelitian yang telah dilakakan. kumpulan dari penelitian yang ada khususnya pada jurusan sistem infomasi, bisa ditemukan di perpustakaan uin fakultas dan perpustakaan uin suska riau. Hal ini menyebabkan kesulitan bagi mahasiswa dalam mendapat informasi mengenai penelitian yang telah dilakukan. Data penelitian masing masing jurusan di fakultas sains dan teknologi belum terkelompokkan dan bahkan penelitian dengan judul yang sama diajukan oleh mahasiswa, karena tidak adanya catalog mengenai penelitian yang telah dilakukan. Masalah ini dapat diselesaikan dengan merancang bangun sebuah aplikasi catalog kerja praktek dan tugas akhir berbasis android. Aplikasi ini dirancang dengan metode prencangan secara OOAD dan metode pengembangan perangkat lunak menggunakan metode prototype. memanfaatkan Smartphone android. Dengan adanya aplikasi ini, mahasiswa dapat melihat penelitian penelitian yang telah dilakukan oleh mahasiswa yang telah tamat. Informasi yang didapat berupa judul dan abstrak dari penelitian dan juga membangun web server untuk mengelola aplikasi catalog tersebut.
Conhecimento e comportamento de um grupo de idosos frente às infecções sexualmente transmissíveis
Authors: Amaral Samantha Vieira Alves , Rocha Renata Lacerda Prata , Junqueira Vinicius Siqueira Seabra , Martins Lorraine Dayanne Moreira , Souza Hemilly Mendonça , Oliveira Pâmela Malheiro , Gomes Andréa Tayse de Lima , Santos Gislene Pace de Souza 
Published: August 2020

Objetivo: Compreender sobre o comportamento e o conhecimento de um grupo de idosos frente às Infecções Sexualmente Transmissíveis (IST's). Métodos: Foi realizada uma pesquisa de campo, de delineamento quantitativo, com 59 idosos participantes de um grupo de convivência do município de Nova Lima - MG, no período de julho a outubro de 2018. Resultados: O estudo evidenciou que os idosos possuem certo conhecimento acerca das IST´S e de suas formas de transmissão. Dentre as IST'S a mais conhecida pelos entrevistados é a HIV/AIDS (64%). Porém a maioria adota comportamento de risco ao não usar o preservativo nas relações sexuais (76,3%), e 81,4% deles não se consideram vulneráveis para adquirir uma IST, justificando tal fato por terem parceiro fixo. Um achado positivo é a ciência da existência da vacina contra a hepatite B (50,8%), identificando-a como uma doença imunoprevenível, disponível inclusive para sua faixa etária. Conclusão: O estudo denota a necessidade de práticas mais assertivas voltadas a esse público de maneira a sensibilizá-los quanto a importância de se proteger nas relações sexuais.
Linking Human Dignity, Vulnerability and Virtue Ethics
Authors: Keenan James F. 
Published: August 2020

Abstract
An ethics of vulnerability, that develops out of an imago Dei/human dignity presupposition, can provide a foundation for a virtue ethics that orients us toward the right responsiveness to contemporary challenges. It explores a vulnerability rooted in imago Dei language and then further develops a vulnerability foundation that is based not primarily on need but on capacity. It concludes offering particular virtues (humility, vigilance, mercy and hospitality) that help in the practice of recognizing human dignity.
Wrestling with the Unspeakable
Authors: Feichtinger Daniela 
Published: August 2020

Abstract
The reader’s subjective experience cannot be easily integrated into an interpretation that claims a certain objectivity and adequacy to the text. For the exegesis of sacred texts, this means that something unspeakable remains, the encounter of which is traditionally described with the theological categories revelation and salvation. This raises the suspicion that by methodically excluding subjectiveness, at least part of the theological character of a text gets lost in interpretation. In order to exemplify the challenge subjectivity poses to scientific interpretation, especially within the framework of a religious community, this paper analyzes documents of the Catholic Church on the interpretation of the bible since 1965. In a next step, the categories of revelation and salvation are traced in Roland Barthes’ essay Camera Lucida (1980). His concepts shed light on the shortcomings of the documents and provide fresh impulses for a transformed understanding and appreciation of the reader’s experience.
PEMANFAATAN KARBON SEBAGAI FILTER UNTUK PENGENDALIAN PENCEMARAN AIR SUNGAI OLEH LOGAM Zn (seng) DARI LIMBAH PABRIK KELAPA SAWIT DI KABUPATEN KUANSING
Authors: Syech Riad , Restina Restina , Malik Usman 
Published: August 2020

A research has been conducated on using charcoal as a filter to control river water pollution with heavy metals from palm oil mill waste based on physical parameters in Kuantan Singingi district using SSA method. The process begin with taking sample from palm iol mill waste output, the the temperature and electrical conductivity of it is mesured. Heavy metal concentration (Zn) is mesured with Atomic Absorption (SSA). The highest electrical conductivity value before filtrasion was found in factory A sampel. The value is 8,87 x 10-4 Ωm-1with 0,241 mg/l Zn concetration. Electrical conductivity value decreased after filtration to 7,11 x 10-4 Ωm-1 with 0,216 mg/l mg/l Zn concetration. While the lowest electrical conductivity value before filtration was found in factory C sample. The value is 4,65 x 10-4 Ωm-1with 0,169 mg/l Zn consetration. Conductivity value decreased after filtration to 4,26 x 10-4 Ωm-1with 0,154 mg/l Zn contretation. These result explain that using charcoal as a filter for pollution control is uqite effective.
PENGARUH TEMPERATUR AKTIVASI FISIKA TERHADAP KINERJA SUPERKAKASITOR BERBASIS ELEKTRODA KARBON DARI AMPAS SAGU
Authors: Taer Erman , Alrifani Zikri , Taslim Rika 
Published: August 2020

The manufacture of activated carbon based on sago pulp as a super-capacitor cell electrode has been successfully performed. Preparation of activated carbon begins with heating of drying raw materials in the sun and followed by oven drying, pre-carbonization, milling, sieving, chemical activation with 2 M concentration KOH solution, pellet printing, carbonization at 600° C using N2 gas followed by physics activation with temperature variation of 700° C; 750° C; 800° C; 850° C; 900° C using water vapor and polishing of pellets are some of the steps that are followed. Carbon electrode density values for each sample of AC 700, AC 750, AC 800, AC 850, and AC 900 are 0,790 g/cm3, 0,791 g/cm3, 0,795 g/cm3, 0,760 g/cm3, dan 0,754 g/cm3. The SEM results show the shape of the particles formed unoccupied. EDX test results show the percentage of carbon reaches 90.13%. The measurement of electrochemical properties performed by cyclic voltammetry method yielded an optimum specific capacitance of 106 F/g obtained at a temperature of 750° C.
PENGOLAHAN HASIL PERIKANAN AIR TAWAR DI KELURAHAN PAHANDUT SEBERANG KECAMATAN PAHANDUT KOTA PALANGKA RAYA
Authors: Yasin Muhamad Noor , Firlianty Firlianty , Najamudin Anang 
Published: August 2020

Kelurahan Pahandut Seberang adalah salah satu kelurahan di wilayah Kecamatan Pahandut Kota Palangkaraya, kelurahan tersebut merupakan salah satu kelurahan yang dipromosikan sebagai tempat sentra kuliner di Kota Palangkaraya. Ikan toman dan ikan patin di Kelurahan ini merupakan ikan yang dipelihara masyarakat pada kolam keramba dan selama ini merupakan sumber penghasilan bagi masyarakat, biasanya ikan ini hanya dijual dalam bentuk ikan segar saja, sehingga penting untuk dilaksanakan pelatihan diversifikasi pengolahan hasil perikanan dari ikan tersebut dalam bentuk olahan nugget, kaki naga dan ekado. Metode dari pelaksanaan kegiatan ini adalah dengan penyuluhan dan pelatihan praktek secara langsung cara pembuatan olahan nugget, kaki naga dan ekado tersebut. Pengolahan hasil perikanan dalam berbagai bentuk olahan ini diharapkan dapat meningkatan nilai gizi dan nilai ekonomi dari ikan yang terdapat di sekitar masyarakat kelurahan Pahandut Seberang
PERBANDINGAN DUA EKSTRAKSI YANG BERBEDA PADA DAUN KELOR (Moringa oleifera, lamk) TERHADAP RENDEMEN EKSTRAK DAN SENYAWA BIOAKTIF YANG DIHASILKAN
Authors: Kiswandono Agung Abadi 
Published: August 2020

Effect of Two Extract Methods on Content and Compound of Leaf of Kelor (Moringa oleifera, Lamk) It had been studied to identify and compare bia active coumpound group and extract content that had been produced of kelor leaf (Moringa oleifera,Lamk) using maserasi extract method and reflux method with methanol and hexane solution respectively. The content produced by reflux with hexane solution was 11.406 % and with methanol was 12.806 %. The content produced by maseration with hexane was 9.976 % and with methanol was 11,863 %. Statistical analysis using T-Test resulted that reflux method and maseration method using hexane solution was significantly different in eror level 5 %, but by using methanol was not significanntly diferent in 5 % eror level. Phytochemistry test for leaf powder had bioactive compound of steroid,tanin, phenol hydroquinon and saponin. In methanol extract of reflux method had bioactive compound of alkaloid, phenolhydroquinon, flavonoid, steroid,triterpenoid, tanin,and saponin, while in maseration method was alcaloid, steroid,tanin,and saponin.Keywords : Moringa oleifera, reflux,maseration, bioactive, phytochemical ABSTRAK Telah dilakukan penelitian dengan tujuan mengidentifikasi dan membandingkan golongan senyawa bioaktif dan rendemen ekstrak yang dihasilkan pada daun kelor (Moringa oleifera, Lamk) dengan metode ekstraksi maserasi dan refluks menggunakan pelarut heksana dan metanol 80%. Rendemen yang dihasilkan dengan metode refluks menggunakan pelarut heksana adalah 11,406% dan metode maserasi 9,976%, sedangkan dengan pelarut Metanol 80%, metode refluks 12,808% dan metode maserasi 11,863%. Uji t antara metode refluks dan maserasi daun kelor menggunakan pelarut heksana berbeda nyata dan menggunakan pelarut metanol 80% tidak berbeda nyata pada taraf nyata 5%. Hasil uji fitokimia pada serbuk daun mengandung senyawa bioaktif steroid, tanin, fenol hidroquinon dan saponin. Pada ekstrak metanol 80%, metode refluks adalah golongan alkaloid, fenol hidrokuinon, flavonoid, steroid , triterpenoid, tanin, dan saponin sedangkan pada maserasi adalah golongan alkaloid, fenol hidrokuinon, flavonoid, steroid, tanin, dan saponin.Kata kunci : Moringa oleifera, refluks, maserasi, bioaktif, fitokimia.