bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Structure Comparison of Ni(II) Complexes Supported by PNCNP and POCOP Pincer Ligands
Authors: Fang Fei , Chang Jiarui , Kang Jiaxin , Zhang Jie , Li Shujun , Chen Xuenian 
Published: May 2020

AbstractIn order to compare the structure and property of the same metal center supported by different types of pincer ligands, a series of Ni(II) pincer complexes, [2,6‐(iPr2PNH)2C6H3]NiX (X=SH, 1 a; SPh, 1 b; SBn, 1 c; BH4, 1 d), were synthesized based on m‐(iPr2PNH)2C6H4 (PNCNP) and fully characterized by multinuclear NMR, FTIR, X‐ray crystallography and elemental analysis. The structures of complexes 1 a–d were compared with those of the corresponding Ni(II) complexes supported by a bis(phosphinite) (POCOP) pincer ligand, [2,6‐(iPr2PO)2C6H3]NiX (X=SH, 2 a; SPh, 2 b; SBn, 2 c; BH4, 2 d). It was found that the Ni‐Cipso and Ni−S bond lengths and the Ni⋅⋅⋅B distance in complexes 1 a–d are comparable to those in complexes 2 a–d; however, the Ni−P bond lengths in complexes 1 a–d are longer than those in complexes 2 a–d. As a result, the nickel center is less tightly chelated by the PNCNP backbone compared with the POCOP framework. Natural population analysis (NPA) of complexes 1 a, 2 a, 1 b and 2 b indicated that the nickel center supported by a PNCNP pincer ligand is less electron‐rich. Cyclic voltammetry study of 1 a and 2 a showed that 2 a is easier to be oxidized.
Daily effects of continuous ICT demands on work–family conflict: Negative spillover and role conflict
Authors: Cho Seonghee , Kim Sooyeol , Chin Sean W. , Ahmad Unber 
Published: May 2020

AbstractGrowing concerns about intensive information and communication technology (ICT) use led to abundant research on its debilitating effects on employees' abilities to meet family demands. Drawing on the stressor–strain model, we conducted a daily diary study to investigate how different types of daily ICT demands experienced during work hours and after work influence work–family conflict (WFC) in the evening. We collected data from 98 full‐time employees (793 day‐level observations) for 10 consecutive workdays to understand employees' work‐nonwork interface experiences, namely, negative spillover and role conflict. First, we examined a multilevel mediation model to test the negative spillover effect of on‐the‐job ICT demands on WFC in the evening via negative affect (NA) at the end of the workday. Second, we investigated the effects of off‐the‐job ICT demands on WFC to provide evidence of role conflict in the nonwork domain. Further, we tested the protective role of boundary control in these phenomena. The multilevel analysis results revealed that different types of ICT demands experienced at work have idiosyncratic impacts on WFC. Also, while extended availability after work hours yields greater WFC, this link was weaker for the employees who perceive high boundary control.
Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease
Authors: Yoon Yongwoo , Kim Hyun Sook , Jeon Iksoo , Noh Jeong-Eun , Park Hyun Jung , Lee Suji , Park In-Hyun , Stevanato Lara , Hicks Caroline , Corteling Randolph , Barker Roger A. , Sinden John D. , Song Jihwan 
Published: May 2020

Abstract
Huntington's disease (HD) is a devastating, autosomal-dominant neurodegenerative disease, for which there are currently no disease-modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the past two decades but have met with only limited success. In this study, we investigated whether a clonal, conditionally immortalized neural stem cell line (CTX0E03), which has already shown safety and signals of efficacy in chronic ischemic stroke patients, could rescue deficits seen in an animal model of HD. After CTX0E03 transplantation into the quinolinic acid-lesioned rat model of HD, behavioral changes were measured using the rotarod, stepping, and staircase tests. In vivo differentiation and neuronal connections of the transplanted CTX0E03 cells were evaluated with immunohistochemical staining and retrograde tracing with Fluoro-Gold. We found that transplantation of CTX0E03 gave rise to a significant behavioral improvement compared with the sham- or fibroblast-transplanted group. Transplanted CTX0E03 formed MSNs (DARPP-32) and GABAergic neurons (GABA, GAD65/67) with BDNF expression in the striatum, while cortically transplanted cells formed Tbr1-positive neurons. Using a retrograde label, we also found stable engraftment and connection of the transplanted cells with host brain tissues. CTX0E03 transplantation also reduced glial scar formation and inflammation, as well as increasing endogenous neurogenesis and angiogenesis. Overall, our results demonstrate that CTX0E03, a clinical-grade neural stem cell line, is effective for preclinical test in HD, and, therefore, will be useful for clinical development in the treatment of HD patients.
Experimental study and numerical analysis on seismic behavior of composite RCS frames
Authors: Li Wei , Xiong Jingang , Wu Lingjie , Yang Kejia 
Published: May 2020

AbstractAn experimental study of the seismic performance of composite frames consisting of reinforced concrete (RC) columns and steel beams (S) is presented in this paper. Three frame specimens—one bare composite RCS frame without slab and two composite RCS frames with slab—were tested under cyclic loading. The test results indicate that two frame specimens with small‐scale steel beams exhibited better ductile behavior and dissipated energy, and the strength and stiffness degradation of the postelastic stage was not obvious. The results indicate that using a slab in the frame is not a good way to improve structural bearing capacity when the linear stiffness of steel beams is large. A plastic limit analysis method is proposed to calculate the lateral ultimate bearing capacity of an RCS frame under seismic action. The calculated results agree well with the test. Three RCS frame specimens were simulated using ABAQUS finite element analysis software. A comparison of the results of the numerical study with the experimental results demonstrates that the finite element model can accurately predict the structural behavior.
Using care navigation to address caregiver burden in dementia: A qualitative case study analysis
Authors: Bernstein Alissa , Merrilees Jennifer , Dulaney Sarah , Harrison Krista L. , Chiong Winston , Ong Paulina , Heunis Julia , Choi Jeff , Walker Reilly , Feuer Julie E. , Lee Kirby , Dohan Daniel , Bonasera Stephen J. , Miller Bruce L. , Possin Katherine L. 
Published: May 2020

AbstractIntroductionMany caregivers of people with dementia experience burden and resulting health effects due to the intensive nature of caregiving. Phone‐ and web‐based care navigation is an innovative model of care that may be useful in addressing caregiver burden in dementia.MethodsQualitative methods (interviews, focus groups, and case study analysis) were used to identify care navigator approaches used to address caregiver burden in dementia as part of a dementia care navigation program.ResultsCare navigators targeted caregiver burden by focusing on strategies to reduce caregiver guilt and frustration, manage patient‐related behavior, address caregiver depression, and improve the relationship between the caregiver and person with dementia. The case studies presented demonstrate the ways that care navigators identified patient and caregiver needs and tailored their approaches to meet the specific social, cultural, economic, and geographic contexts of the dyads with which they worked.DiscussionFindings provide insights into strategies used to address caregiver burden through care navigation. Care navigators who speak the same language as the caregivers with whom they work and who have an in‐depth understanding of the symptoms of different dementia syndromes may be particularly effective.
If ineffective levels of transforming growth factors and their receptor account for old age being a risk factor for Alzheimer's disease, then increasing TGFBR2 might be therapeutic
Authors: Fessel Jeffrey 
Published: May 2020

AbstractIf it is correct that ineffective levels of transforming growth factors beta and their receptor account for old age being a risk factor for Alzheimer's disease (AD), then increasing TGFBR2 might be therapeutic. Pacltaxel is a direct way to increase TGFBR2 levels. Indirect ways that will increase TGFBR2, include decreasing the levels of c‐myc because that will lower the miRNA cluster 17‐92, particularly its miR‐17 and miR‐20a components; and raising EGFR because that also will increase TGFBR2. Metformin and desferrioxamine are drugs that decrease c‐myc; and statins increase levels of EGF. Clinical trials using those drugs, would demonstrate whether they decrease the progression from amnestic mild cognitive impairment to AD.
Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity
Authors: Vardarajan Badri , Kalia Vrinda , Manly Jennifer , Brickman Adam , Reyes‐Dumeyer Dolly , Lantigua Rafael , Ionita‐Laza Iuliana , Jones Dean P. , Miller Gary W. , Mayeux Richard 
Published: May 2020

AbstractIntroductionWe investigated metabolites in plasma to capture systemic biochemical changes associated with Alzheimer's disease (AD).MethodsMetabolites in plasma were measured in 59 AD cases and 60 healthy participants of African American (AA), Caribbean Hispanic (CH), and non‐Hispanic white (NHW) ancestry using untargeted liquid‐chromatography–based ultra‐high‐resolution mass spectrometry. Metabolite differences between AD and healthy, ethnic groups and apolipoprotein E gene (APOE) ε4 status were analyzed. Untargeted network analysis identified pathways enriched in AD‐associated metabolites.ResultsA total of 5929 annotated metabolites were measured. Partial least squares discriminant analysis (PLS‐DA) inferred that AD clustered separately from healthy controls (area under the curve [AUC] = 0.9816); discriminating pathways included glycerophospholipid, sphingolipid, and non‐essential amino acid (alanine, aspartate, glutamate) metabolism. Metabolic features in AA clustered differently from CH and NHW (AUC = 0.9275), and differed between APOE ε4 carriers and non‐carriers (AUC = 0.9972).DiscussionMetabolites, specifically lipids, were associated with AD, APOE ε4, and ethnic group. Metabolite profiling can identify perturbed AD pathways, but genetic and ancestral background need to be considered.
Exclusive quarkonium production or decay in soft gluon factorization
Authors: Li Rong , Feng Yu , Ma Yan-Qing 
Published: May 2020

AbstractIn this paper, we study the application of the recently proposed soft gluon factorization (SGF) to exclusive quarkonium production or decay. We find that in the nonrelativistic QCD factorization framework there are too many nonperturbative parameters. Thanks to the factorization of kinematical physics from dynamical physics, the SGF significantly reduces the number of nonperturbative parameters. Therefore, the SGF can improve our predictive power of exclusive quarkonium production or decay. By applying to ηc + γ production at B-factories, our result is the closest one to data among all theoretical calculations.
Third-order relativistic hydrodynamics: dispersion relations and transport coefficients of a dual plasma
Authors: Diles Saulo M. , Mamani Luis A.H. , Miranda Alex S. , Zanchin Vilson T. 
Published: May 2020

AbstractHydrodynamics is nowadays understood as an effective field theory that describes the dynamics of the long-wavelength and slow-time fluctuations of an underlying microscopic theory. In this work we extend the relativistic hydrodynamics to third order in the gradient expansion for neutral fluids in a general curved spacetime of d dimensions. We find 58 new transport coefficients, 19 due to third-order scalar corrections and 39 due to tensorial corrections. In the particular case of a conformal fluid, the number of new transport coefficients is reduced to 19, all of them due to third-order tensorial corrections. The dispersion relations of linear fluctuations in the third-order relativistic hydrodynamics is obtained, both in the rest frame of the fluid and in a general moving frame. As an application we obtain some of the transport coefficients of a relativistic conformal fluid in three dimensions by using the AdS/CFT correspondence. These transport coefficients are extracted from the dispersion relations of the linear fluctuations. The gravity dual of the fluctuations in this conformal fluid is described by the gravitational perturbations of four-dimensional anti-de Sitter black branes, which are solutions of the Einstein equations with a negative cosmological constant. To find the hydrodynamic quasinormal modes (QNMs) of the scalar sector we use the SUSY quantum mechanics of the gravitational perturbations of four-dimensional black branes. Such a symmetry allows us to find the wavefunction of the scalar (or sound) sector in the hydrodynamic limit directly from the wavefunction of the vector (or shear) sector, which is usually easier to be found because the perturbation wave equations for the vector sector are much simpler than the ones for the scalar sector.
Oncological outcome and recurrence pattern analysis after involved-field irradiation in combination with rituximab for early-stage nodal and extranodal follicular lymphoma
Authors: König Laila , Herfarth Klaus , Hörner-Rieber Juliane , Dietrich Sascha , Wiegel Thomas , Debus Jürgen , Viardot Andreas 
Published: May 2020

Abstract
Purpose
Combined radioimmunotherapy (RIT) in follicular lymphomas (FL) has shown promising treatment efficacy in the Mabthera® and Involved field Radiation (MIR) study. Aim of this study was to analyze treatment efficacy and recurrence patterns after RIT in early-stage nodal and extranodal FL.

Methods
We reviewed 107 patients who were treated with combined RIT in two centers. Treatment consisted of 4 × rituximab followed by RIT with 4 × rituximab and involved field (IF) radiotherapy with 30/40 Gy. Median follow-up period was 71 months. In contrast to the MIR study, extranodal involvement and grade 3A histology were included in the analysis.

Results
Extranodal involvement and grade 3A histology were present in 21.8% and 13.1%, respectively. Overall response rate (ORR) after 4 × rituximab, after completion of RIT, and after 6 months was 78.1%, 98.8%, and 98.8%, respectively, with increasing rates of complete remissions (CR). Predictive factors associated with superior PFS were tumor size, completely excised lymphomas, and response to first 4 × rituximab. 5‑year PFS rate was 87.3%, with mostly outfield recurrences (94.1%). Second-line treatment was effective, with 53.3% CR and 46.7% partial remissions (PR). 5‑year OS was 98.1%. RIT was tolerated well, with mainly grade 1–2 acute side effects.

Conclusion
The real-world efficacy of RIT is comparable with the results of the MIR study. Additionally, this analysis shows that extranodal involvement and grade 3A histology are not associated with inferior PFS.
Higher pyruvate levels after Achilles tendon rupture surgery could be used as a prognostic biomarker of an improved patient outcome
Authors: Capone Gianluigi , Svedman Simon , Juthberg Robin , Edman Gunnar , Ackermann Paul W. 
Published: May 2020

Abstract
Purpose
The primary aim of this study was to assess the relationship between the metabolites lactate and pyruvate in the healing tendon after Achilles tendon rupture (ATR) and patient-reported outcome at 6 and 12 months. A secondary aim was to evaluate which underlying factors regulate lactate and pyruvate concentrations.

Methods
Lactate and pyruvate concentrations were measured two weeks post-operatively in both the healing- and healthy Achilles tendon in 109 patients (90 men, 19 women; mean age 40 ± 7.9 years). Patient demographics, degree of physical activity, timing of surgery, operation time, patient-reported loading and step counts were investigated in relation to metabolite concentrations. At 6 and 12 months, the Achilles tendon Total Rupture Score (ATRS) questionnaire was used to assess patient outcome.

Results
The mean number of steps taken during the post-operative days 1–10 was the only factor significantly related to the mean concentration of lactate (R2 = 0.34, p = 0.038), and pyruvate (R2 = 0.46, p = 0.006). Pyruvate was demonstrated as the only factor significantly associated with ATRS at both 6 months (R2 = 0.32, p = 0.003) and at 12 months (R2 = 0.37, p = 0.004) using multiple linear regression.

Conclusion
The mean concentration of pyruvate during early ATR healing may predict patient outcome at 6 and 12 months post-operatively and possibly be used as a biomarker of healing. Early mobilization with an increased number of steps taken is an important clinical strategy to improve the metabolite concentrations during healing.

Level of evidence
III
On the empirical estimator of the boundary in inverse first-exit problems
Authors: Gür Sercan , Pötzelberger Klaus 
Published: May 2020

AbstractFirst-exit problems for the Brownian motion (W(t)) or general diffusion processes, have important applications. Given a boundary b(t), the distribution of the first-exit time $$\tau $$
τ
has to be computed, in most cases numerically. In the inverse first-passage-time problems, the distribution of $$\tau $$
τ
is given and the boundary b has to be found. The boundary and the density of $$\tau $$
τ
satisfy a Volterra integral equation. Again numerical methods approximate the solution b for given distribution of $$\tau $$
τ
. We propose and analyze estimators of b for a given sample $$\tau _1,\ldots ,\tau _n$$

τ
1

,
…
,

τ
n

of first-exit times. The first estimator, the empirical estimator, is the solution of a stochastic version of the Volterra equation. We prove that it is strongly consistent and we derive an upper bound for its asymptotics convergence rate. Finally, this estimator is compared to a Bayesian estimator, which is based on an approximate likelihood function. Monte Carlo experiments suggests that the empirical estimator is simple, computationally manageable and outperforms the alternative procedure considered in this paper.
The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development
Authors: Walker Paul A. , Ryder Stephanie , Lavado Andrea , Dilworth Clive , Riley Robert J. 
Published: May 2020

AbstractEarly identification of toxicity associated with new chemical entities (NCEs) is critical in preventing late-stage drug development attrition. Liver injury remains a leading cause of drug failures in clinical trials and post-approval withdrawals reflecting the poor translation between traditional preclinical animal models and human clinical outcomes. For this reason, preclinical strategies have evolved over recent years to incorporate more sophisticated human in vitro cell-based models with multi-parametric endpoints. This review aims to highlight the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery and compares/contrasts these with recent activities in our lab. The key role of human exposure and hepatic drug uptake transporters (e.g. OATPs, OAT2) is also elaborated.
Solving high-level Petri games
Authors: Gieseking Manuel , Olderog Ernst-Rüdiger , Würdemann Nick 
Published: May 2020

AbstractThe manual implementation of local controllers for autonomous agents in a distributed and concurrent setting is an ambitious and error-prune task. Synthesis algorithms, however, allow for the automatic generation of such controllers given a formal specification of the system’s goal. Recently, high-level Petri games were introduced to allow for a concise modeling technique of distributed systems with a safety objective. One way of solving these games is by a translation to low-level Petri games and applying an existing solving algorithm. In this paper we present a new solving technique for a subclass of high-level Petri games with a single uncontrollable player, a bounded number of controllable players, and a local safety objective. The technique exploits symmetries in the high-level Petri game. We report on encouraging experimental results of a prototype implementation generating the reduced state space. The results for four existing and one new benchmark family show a state space reduction by up to three orders of magnitude.
Off-the-shelf automated analysis of liveness properties for just paths
Authors: Bouwman Mark , Luttik Bas , Willemse Tim 
Published: May 2020

AbstractWe enrich the operational semantics of a simple process calculus with ACP-style communication with a concurrency relation, so that for every process expression there exists an associated notion of just path. We then present sufficient conditions on the communication function and the syntax of process expressions that facilitate the formulation of justness on the level of labels rather than on individual transitions, taking a designated set of signals into account. This paves the way for the formulation of liveness properties under justness assumptions in the modal $$\mu $$μ-calculus and their verification on process specifications with the mCRL2 toolset.
Out for coffee: with Rob
Authors: Fehnker Ansgar 
Published: May 2020

AbstractI have known Rob van Glabbeek as a colleague for 16 years, of which eight years were in the same research group. However, this only amounts to less than half of his professional life which started in the mid-1980s at the Centrum voor Wiskunde en Informatica in Amsterdam. In this article, I am trying to piece together the information I got from colleagues as well as from Rob himself—to the best of my recollection—to give an insight into Rob as a colleague, researcher, and person.
Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in the gastrointestinal tract
Authors: Albadran Hanady A. , Monteagudo-Mera Andrea , Khutoryanskiy Vitaliy V. , Charalampopoulos Dimitris 
Published: May 2020

AbstractThis study reports the development of a novel and simple formulation for probiotic delivery using chitosan-coated agar-gelatin gel particles. This methodology involves the production of agar-gelatin particles by thermally treating a mixture of agar and gelatin solutions at high temperatures (121 °C) and subsequently coating with chitosan. The particles were able to protect the probiotic strain Lactobacillus plantarum NCIMB 8826 during incubation for 2 h in simulated gastric fluid (pH 2), as no statistically significant loss (P > 0.05) in cell concentration was observed, and also resist dissolution in simulated intestinal fluid (pH 7.2). Interestingly, this protection is related to the fact that the intense thermal treatment affected the physicochemical properties of agars and resulted in the formation of a strong and tight polymer network, as indicated by the X-ray diffraction (XRD) analysis. Using an in vitro faecal batch fermentation model simulating the conditions of the distal part of the large intestine (pH 6.7–6.9), it was demonstrated by quantitative real-time PCR that the majority of L. plantarum cells were released from the agar-gelatin particles within 30 to 48 h. Overall, this work led to the development of a novel methodology for the production of probiotic-containing particles, which is simpler compared with current encapsulation technologies and has a lot of potential to be used for the controlled release of probiotics and potentially other solid bioactives in the large intestine.Key Points• Chitosan gel particles is a simple and scalable method of probiotic encapsulation.• Autoclaving agar-gelatin particles increases their stability at low pH.• Chitosan gel particles protected L. plantarum during gastrointestinal conditions.• Probiotics could be controlled release in the colon using chitosan gel particles.