bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobilising the Past: Towards a Conceptualisation of Retro‐Innovation
Authors: Zagata Lukas , Sutherland Lee‐Ann , Hrabák Jiří , Lostak Michal 
Published: May 2020

AbstractIn this article we develop a conceptualisation of retro‐innovation, simply defined as the purposeful revival of historic practices, ideas and/or technologies, and apply this conceptualisation to the analysis of the development of the organic farming movement in the Czech Republic. Within the agricultural sector, we argue that retro‐innovation represents a critical practice, undertaken to counter modernisation trends. Retro‐innovation processes are thus often embedded within social movements. We identify four key mechanisms of retro‐innovation: reflexivity, reminiscence, revival, integration and learning. Drawing on 25 key informant interviews, we demonstrate how the growing critique of socialist collective farms in the 1980s coalesced with new policy supports in the 1990s to enable re‐learning and revival of traditional farming practices, situating organic farming approaches as the revitalisation of positive historical practices. However, as the Czech case demonstrates, the numerous options for and social memories of past innovations can lead to fragmentation of efforts and products.
Outcome of COVID‐19 in liver transplant recipients: A preliminary report from Northwestern Italy
Authors: Patrono Damiano , Lupo Francesco , Canta Francesca , Mazza Elena , Mirabella Stefano , Corcione Silvia , Tandoi Francesco , De Rosa Francesco Giuseppe , Romagnoli Renato 
Published: June 2020

AbstractCovid‐19 pandemic is deeply affecting transplant activity worldwide. It is unclear whether solid organ transplant recipients are at increased risk of developing severe complications and how they should be managed, also concerning immunosuppression. This is a report about the course and management of SARS‐CoV‐2 infection in liver transplant recipients from a single center in Northwestern Italy in the period March‐April 2020. Three patients who were treated at our institution are reported in detail, whereas summary data are provided for those managed at peripheral Hospitals. Presentation varied from asymptomatic to rapidly progressive respiratory failure due to bilateral interstitial pneumonia. Accordingly, treatment and changes to immunosuppression were adapted to the severity of the disease. Overall mortality was 20%, whereas Covid‐related mortality was 10%. Two cases of prolonged (>2 months) viral carriage were observed in two asymptomatic patients who contracted the infection in the early course after transplant. Besides depicting Covid‐19 course and possible treatment scenarios in liver transplant patients, these cases are discussed in relation to the changes in our practice prompted by Covid‐19 epidemic, with potential implications for other transplant programs.
Do fluctuations in crude oil prices have symmetric or asymmetric effects on the real exchange rate? Empirical evidence from Indonesia
Authors: Baek Jungho , Choi Yoon Jung 
Published: May 2020

AbstractCurrent research on the oil price impacts on exchange rates typically relies on the assumption that fluctuations in crude oil prices have symmetric impacts on a country's real exchange rate. Thus, the contribution of the paper is to use the non‐linear autoregressive distributed lag (ARDL) method of Shin, Yu, and Greenwood‐Nimmo (2014) and examine whether crude oil prices are asymmetrically passed on to the real exchange rate in the case of Indonesia. We uncover that oil price changes indeed asymmetrically affect the Indonesian rupiah in both the long and short run; i.e., the movement in the Indonesian rupiah appears to be more responsive to rising oil prices than to declining oil prices.
The not‐so‐generalised effects of the Generalized System of Preferences
Authors: Ornelas Emanuel , Ritel Marcos 
Published: May 2020

AbstractWe use an empirical gravity equation to study how non‐reciprocal trade preferences (NRTPs), enacted mainly through the Generalized System of Preferences, affect the exports of the beneficiary nations. In line with existing studies, the average trade effect stemming from non‐reciprocal preferences is highly unstable across specifications. However, once we allow for heterogeneous effects, results become robust and economically important. Specifically, NRTPs have a strong effect on the exports of beneficiaries when they are members of the World Trade Organization and are very poor. Not‐so‐poor beneficiaries also expand foreign sales, but only if they are not WTO members. For all others, the average export effects of NRTPs are mute.
Assessing the environmental and economic efficacy of two integrated constructed wetlands at mitigating eutrophication risk from sewage effluent
Authors: Cooper Richard J. , Hawkins Elizabeth , Locke Jake , Thomas Terry , Tosney Jonah 
Published: May 2020

AbstractThe nutrient removal efficiency of two integrated constructed wetlands (ICWs) installed at commercial wastewater treatment plants (WWTPs) in Norfolk, UK, is assessed – the River Ingol ICW (1 year old) and the River Mun ICW (5 years old). Analysing water samples collected across the ICWs between February and September 2019, significant reductions in both effluent nutrient concentration and load were recorded. At the River Mun ICW, mean nitrate and phosphate concentrations were reduced by ~63% across the wetland, whilst nutrient loadings were reduced by ~57%. At the River Ingol ICW, mean nitrate and phosphate concentrations were reduced by ~30%, whilst nutrient loadings were reduced by ~70%. Economically, the total capital cost of both ICWs was comparable at £31‐39 per person served. Overall, this study demonstrates ICWs can significantly reduce the eutrophication risk associated with WWTP discharges and can do so whilst providing a cost‐effective alternative to conventional tertiary wastewater treatment.
Solid organ xenotransplantation at the interface between research and clinical development: Regulatory aspects
Authors: Schuurman Henk‐Jan , Hoogendoorn Karin 
Published: June 2020

AbstractDuring the last years, progress has been made in survival and function of pig‐to‐non‐human primate organ xenotransplantation using organs from genetically modified pigs and immunosuppression regimens that are clinically acceptable. This, together with increased insights into a low risk of pig‐to‐human transmission of porcine endogenous retrovirus, has opened the perspective of starting with first‐in‐human trials with xenogeneic organs. The regulatory path to clinical development is complex. Unlike an organ from human donors, an organ from pigs, either genetically modified or wild‐type pigs, is considered a medicinal product for human use and hence is under regulatory oversight, in the United States by the Food and Drug Administration and in Europe by the national competent authorities of the member states as well as the European Medicines Agency. Related to the status of medicinal product, “(current) good practices” apply in the process of generating a xenogeneic organ through to the transplantation into a patient and life‐long follow‐up. In addition, guidances for xenotransplantation products and genetically modified organisms do apply as well. This commentary focuses on regulatory aspects of transplantation of organs from genetically modified pigs into humans, with the intention to facilitate the interactions between regulatory agencies and institutions (sponsors) in research and clinical development of these organs, to support the perspective of speeding up the process with a proper entry in clinical application, to fill an unmet medical need in patients with end‐stage organ disease.
Molecular phylogeny and diversity of penaeid shrimps (Crustacea: Decapoda) from South‐East Asian waters
Authors: Hurzaid Amirah , Chan Tin‐Yam , Mohd Nor Siti Azizah , Muchlisin Zainal Abidin , Chen Wei‐Jen 
Published: May 2020

AbstractThe decapod family Penaeidae comprises most of the economically important marine shrimp species. Its members are widespread throughout the world, with its highest species diversity centred in the Indo‐West Pacific region. Despite this importance, their taxonomy, classification and phylogeny are not yet settled due in part to incongruence among hypotheses proposed from molecular versus morphological studies. In this study, using a thorough taxonomic sampling of especially the South‐East Asian species, we aim to (a) utilize a reconstructed phylogeny to test the monophyly of the Penaeidae and its currently recognized genera and (b) explore its species diversity in South‐East Asian waters. To infer the phylogeny, a combined gene data set (including 109 ingroup and six outgroup taxa) of mitochondrial genes, COI and 16S rRNA, and two nuclear genes, NaK and PEPCK, was utilized. To explore its diversity, another data set that included 371 COI gene sequences (231 newly generated and 140 retrieved from public sources) was compiled and subsequently analysed with two different tools (ABGD and bPTP) for species delimitation. Other than supporting the non‐monophyly of the Penaeidae with the Sicyoniidae nested within the penaeid tribe Trachypenaeini, the genera Penaeus, Mierspenaeopsis and Parapenaeopsis were also revealed to be polyphyletic. Our species delimitation analysis inferred that 94 putative species actually existed within the 71 morphospecies reviewed, indicating an underestimated biodiversity in this family and the potential presence of new species within the following morphospecies: Kishinouyepenaeopsis cornuta, K. incisa, Mierspenaeopsis sculptilis, M hardwicki, Parapenaeopsis coromandelica and Penaeus monodon.
Building Inclusive Communities in Youth Sport for Lesbian-Parented Families
Authors: Trussell Dawn E. 
Published: June 2020

This interpretative study examines the complexities of lesbian parents’ experiences in organized youth sport programs. Specifically, it seeks to understand youth sport as a potential site for social change that facilitates a sense of inclusive community for diverse family structures. Using thematic analysis, the author examines perspectives of nine participants from Australia, Canada, and the United States. Emphasis is placed on how the lesbian parents (a) negotiate heightened visibility, sexual stigma, and parental judgment; (b) foster social relationships through participation, volunteerism, and positive role models; and (c) create shared understanding toward building an inclusive sport culture. The findings call attention to the importance of intentional and unintentional acts (by families as well as sport organizations) that create a sense of community and an inclusive organizational culture. The connection of lesbian parents’ experiences to broader concepts, such as sexual stigma and transformative services, are also examined within the context of youth sport.
Insulin pricing and other major diabetes-related concerns in the USA: a study of 46 407 tweets between 2017 and 2019
Authors: Ahne Adrian , Orchard Francisco , Tannier Xavier , Perchoux Camille , Balkau Beverley , Pagoto Sherry , Harding Jessica Lee , Czernichow Thomas , Fagherazzi Guy 
Published: June 2020

IntroductionLittle research has been done to systematically evaluate concerns of people living with diabetes through social media, which has been a powerful tool for social change and to better understand perceptions around health-related issues. This study aims to identify key diabetes-related concerns in the USA and primary emotions associated with those concerns using information shared on Twitter.Research design and methodsA total of 11.7 million diabetes-related tweets in English were collected between April 2017 and July 2019. Machine learning methods were used to filter tweets with personal content, to geolocate (to the USA) and to identify clusters of tweets with emotional elements. A sentiment analysis was then applied to each cluster.ResultsWe identified 46 407 tweets with emotional elements in the USA from which 30 clusters were identified; 5 clusters (18% of tweets) were related to insulin pricing with both positive emotions (joy, love) referring to advocacy for affordable insulin andsadnessemotions related to the frustration of insulin prices, 5 clusters (12% of tweets) to solidarity and support with a majority ofjoyandloveemotions expressed. The most negative topics (10% of tweets) were related to diabetes distress (24%sadness,27%anger, 21%fearelements), to diabetic and insulin shock (45%anger, 46%fear) and comorbidities (40%sadness).ConclusionsUsing social media data, we have been able to describe key diabetes-related concerns and their associated emotions. More specifically, we were able to highlight the real-world concerns of insulin pricing and its negative impact on mood. Using such data can be a useful addition to current measures that inform public decision making around topics of concern and burden among people with diabetes.
Guide to performing equine castration
Authors: Woodford Nigel 
Published: June 2020

Background:The behaviour of the adult entire male horse is often undesirable and the vastly eased management of the more biddable gelding means that clients often request castration of their horses. It can be an intimidating procedure due to the potential serious complications and the associated health and safety considerations. A good solid approach to the clinical aspects of castration and its complications helps provide the practitioner with confidence to undertake this surgery. Owners perceive this as a routine procedure, but their frequent requirement for the surgery to be conducted at their premises with only their assistance renders this an operation that demands careful discussion and thereby informed consent.Aim of the article:This article provides a guide to performing castrations in horses and discusses the common complications and their management.
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial
Authors: Zamarin Dmitriy , Walderich Sven , Holland Aliya , Zhou Qin , Iasonos Alexia E , Torrisi Jean M , Merghoub Taha , Chesebrough Lewis F , Mcdonnell Autumn S , Gallagher Jacqueline M , Li Yanyun , Hollmann Travis J , Grisham Rachel N , Erskine Courtney L , Block Mathew S , Knutson Keith L , O’Cearbhaill Roisin E , Aghajanian Carol , Konner Jason A 
Published: June 2020

BackgroundImmune checkpoint inhibitors (ICIs) to date have demonstrated limited activity in advanced ovarian cancer (OC). Folate receptor alpha (FRα) is overexpressed in the majority of OCs and presents an attractive target for a combination immunotherapy to potentially overcome resistance to ICI in OCs. The current study sought to examine clinical and immunologic responses to TPIV200, a multiepitope FRα vaccine administered with programmed death ligand 1 (PD-L1) inhibitor durvalumab in patients with advanced platinum-resistant OC.MethodsFollowing Simon two-stage phase II trial design, 27 patients were enrolled. Treatment was administered in 28-day cycles (intradermal TPIV200 and granulocyte-macrophage colony-stimulating factor (GM-CSF) for 6 cycles and intravenous durvalumab for 12 cycles). Primary endpoints included overall response rate and progression-free survival at 24 weeks. Translational parameters focused on tumor microenvironment, PD-L1 and FRα expression, and peripheral vaccine-specific immune responses.ResultsTreatment was well tolerated, with related grade 3 toxicity rate of 18.5%. Increased T cell responses to the majority of peptides were observed in all patients at 6 weeks (p<0.0001). There was one unconfirmed partial response (3.7%) and nine patients had stable disease (33.3%). Clinical benefit was not associated with baseline FRα or PD-L1 expression. One patient with prolonged clinical benefit demonstrated loss of FRα expression and upregulation of PD-L1 in a progressing lesion. Despite the low overall response rate, the median overall survival was 21 months (13.5–∞), with evidence of benefit from postimmunotherapy regimens.ConclusionsCombination of TPIV200 and durvalumab was safe and elicited robust FRα-specific T cell responses in all patients. Unexpectedly durable survival in this heavily pretreated population highlights the need to investigate the impact of FRα vaccination on the OC biology post-treatment.
Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients — correlation with IVF parameters
Authors: Massa Estefanía , Pelusa Fabián , Lo Celso Agustina , Madariaga María José , Filocco Luciana , Morente Carlos , Ghersevich Sergio 
Published: May 2020

Since our previous results suggest that lactoferrin (LF) might have roles in the reproductive process and that its levels might change in the female tract as a response to various factors, the aim of this investigation was to assess whether LF levels in cervical secretions correlate with reproductive parameters from in vitro fertilization (IVF) patients. Cervical fluid samples were obtained from 34 women under 40 years old enrolled for assisted reproduction techniques, and LF concentration was measured. The mean total protein concentration in all cervical fluid samples was 842.8 ± 116.9 µg/mL. The mean concentration of LF was 0.73 ± 0.06 ng LF/µg of total proteins. We observed that higher LF levels in cervical fluid correlated with lower IVF rates when all patients were analyzed; this negative correlation was also sustained when only patients ≥35 years were studied. The mean LF concentration in cervical fluid was significantly lower among patients with normal IVF rates than in those with values 50% or less. Using a LF cutoff value of 0.83 ng/μg of total proteins, the study revealed a significant association between the LF levels below 0.83 ng/µg of total proteins and IVF rates above 50%. LF levels in cervical mucus could potentially be used as a marker of fertilization outcome.
Haldane insulator in the 1D nearest-neighbor extended Bose-Hubbard model with cavity-mediated long-range interactions
Authors: Sicks Johannes , Rieger Heiko 
Published: June 2020

Abstract

In the one-dimensional Bose-Hubbard model with on-site and nearest-neighbor interactions, a gapped phase characterized by an exotic non-local order parameter emerges, the Haldane insulator. Bose-Hubbard models with cavity-mediated global range interactions display phase diagrams, which are very similar to those with nearest-neighbor repulsive interactions, but the Haldane phase remains elusive there. Here we study the one-dimensional Bose-Hubbard model with nearest-neighbor and cavity-mediated global-range interactions and scrutinize the existence of a Haldane Insulator phase. With the help of extensive quantum Monte-Carlo simulations we find that in the Bose-Hubbard model with only cavity-mediated global-range interactions no Haldane phase exists. For a combination of both interactions, the Haldane Insulator phase shrinks rapidly with increasing strength of the cavity-mediated global-range interactions. Thus, in spite of the otherwise very similar behavior the mean-field like cavity-mediated interactions strongly suppress the non-local order favored by nearest-neighbor repulsion in some regions of the phase diagram.

Graphical abstract
Planar Graph Perfect Matching Is in NC
Authors: Anari Nima , Vazirani Vijay V. 
Published: May 2020

Is perfect matching in NC? That is, is there a deterministic fast parallel algorithm for it? This has been an outstanding open question in theoretical computer science for over three decades, ever since the discovery of RNC perfect matching algorithms. Within this question, the case of planar graphs has remained an enigma: On the one hand, counting the number of perfect matchings is far harder than finding one (the former is #P-complete and the latter is in P), and on the other, for planar graphs, counting has long been known to be in NC whereas finding one has resisted a solution.
In this article, we give an NC algorithm for finding a perfect matching in a planar graph. Our algorithm uses the above-stated fact about counting perfect matchings in a crucial way. Our main new idea is an NC algorithm for finding a face of the perfect matching polytope at which a set (which could be polynomially large) of conditions, involving constraints of the polytope, are simultaneously satisfied. Several other ideas are also needed, such as finding, in NC, a point in the interior of the minimum-weight face of this polytope and finding a balanced tight odd set.
Epithelial–Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance
Authors: Gooding Alex J. , Schiemann William P. 
Published: June 2020

Abstract
Epithelial–mesenchymal transition (EMT) programs play essential functions in normal morphogenesis and organogenesis, including that occurring during mammary gland development and glandular regeneration. Historically, EMT programs were believed to reflect a loss of epithelial gene expression signatures and morphologies that give way to those associated with mesenchymal cells and their enhanced migratory and invasive behaviors. However, accumulating evidence now paints EMT programs as representing a spectrum of phenotypic behaviors that also serve to enhance cell survival, immune tolerance, and perhaps even metastatic dormancy. Equally important, the activation of EMT programs in transformed mammary epithelial cells not only enhances their acquisition of invasive and metastatic behaviors, but also expands their generation of chemoresistant breast cancer stem cells (BCSC). Importantly, the net effect of these events results in the appearance of recurrent metastatic lesions that remain refractory to the armamentarium of chemotherapies and targeted therapeutic agents deployed against advanced stage breast cancers. Here we review the molecular and cellular mechanisms that contribute to the pathophysiology of EMT programs in human breast cancers and how these events impact their “stemness” and acquisition of chemoresistant phenotypes.
Marx on Social Reproduction
Authors: Cammack Paul 
Published: May 2020

Abstract
Marx is generally reckoned to have had too little to say about what has come to be defined as ‘social reproduction’, largely as a consequence of too narrow a focus on industrial production, and a relative disregard for issues of gender. This paper argues in contrast that the approach he developed with Engels and in Capital, Volume 1, provides a powerful framework for its analysis. After an introductory discussion of recent literature on social reproduction the second section sets out Marx’s approach to the ‘production of life, both of one’s own in labour and of fresh life in procreation’. The third addresses his account of reproduction in Capital, Volume 1, Chapter 23. The fourth and fifth compare the relationship of the family to industry and exchange as depicted in Capital and in the present day respectively. The conclusion suggests some implications for theories of social reproduction.
The Feminist Case Against Relational Autonomy
Authors: Khader Serene J. 
Published: May 2020

Abstract
Feminist socially constitutive conceptions of autonomy make the presence of idealized social conditions necessary for autonomy. I argue that such conceptions cannot, when applied under nonideal conditions, play two key feminist theoretical roles for autonomy: the roles of anti-oppressive character ideal and paternalism-limiting concept. Instead, they prescribe action that reinforces oppression. Treated as character ideals, socially constitutive conceptions of autonomy ask agents living under nonideal ones to engage in self-harm or self-subordination. Moreover, conceptions of autonomy that make idealized social conditions a requirement of autonomy yield the conclusion that oppressed agents are appropriate objects of paternalism.