bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PILOT STUDY ON IDENTIFICATION AND MANAGEMENT OF DRUG INDUCED SEXUAL DYSFUNCTION: A COLLABORATIVE APPROACH BY CLINICAL PHARMACIST AND PSYCHIATRIST
Authors: SHAKYA BILESH , BABU TIRIN , SHAFI P. MOHAMED , TEJASRI VEMURI , SEBASTIAN JUNY , MANOHAR J. SHIVANANDA , LUCCA JISHA MYALIL 
Published: February 2020

Objective: To assess the role of clinical pharmacists in the identification and management of drug-induced sexual dysfunction in collaboration with the psychiatrist and also to determine the prevalence and pattern of drug-induced sexual dysfunction, identify nature and extend of drug-induced sexual dysfunction, and assess the pattern of management of drug-induced sexual dysfunction.
Methods: This periodic prevalence interventional study was carried out among patients who visited the psychiatric department of a university hospital over three month’s period. Patients were screened for sexual dysfunction using the Arizona Sexual Experience Scale (ASEX) by study pharmacists.
Results: Of the 100 patients reviewed, only 50% of subjects met the study criteria. Depression (42%) was the most common clinical diagnosis among the study patients. The overall prevalence of drug-induced sexual dysfunction was 16%. A higher incidence of drug-induced sexual dysfunction was observed in men (62.5%). Decrease libido (40%) was the most prominently observed drug-induced sexual dysfunction in both genders. Antidepressant (50%) was the most common class of drugs implicated in sexual dysfunction. Drug-induced sexual dysfunction was pharmacologically managed with vaginal lubrication (40%), Tadalafil (20%) and Tadalafil+Dapoxetine combination (40%).
Conclusion: With this study, provided a vision, further how prospective studies in this arena may be carried out for better understanding drug-induced sexual dysfunction and how a clinical pharmacist can contribute for better health care of patients in the sex clinic by collaborating with medical practitioners.
RP-HPLC AND CHEMOMETRIC METHODS FOR THE DETERMINATION OF TWO ANTI-DIABETIC MIXTURES; METFORMIN HYDROCHLORIDE-CANAGLIFLOZIN AND METFORMIN HYDROCHLORIDE-GLICLAZIDE IN THEIR PHARMACEUTICAL FORMULATION
Authors: AL-BATHISH MALAK Y. , GAZY AZZA A. , EL-JAMAL MARWA K. 
Published: February 2020

Objective: To develop and validate novel more sensitive analytical methods for the concurrent quantification of metformin-canagliflozin and metformin-gliclazide in their bulk forms and in their pharmaceutical preparations.
Methods: Two methods were developed based on several chemometric assisted spectrophotometric methods and a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). The first method applies different spectrophotometric chemometric assisted methods, including ratio difference, derivative ratio and extended ratio subtraction method, while the second method describes a RP-HPLC separation of metformin hydrochloride-canagliflozin and metformin hydrochloride-gliclazide binary mixtures using a C18 column with a mobile phase consisting of acetonitrile: potassium dihydrogen phosphate (adjusted to pH 3) with sodium lauryl sulphate as additive in the ratio of 30:70 (%v/v) in isocratic elution mode at 1 ml/min.
Results: The proposed methods were able to quantify each of the studied drugs in their binary mixtures with high percentage recoveries in both methods. The spectrophotometric methods were able to quantify each of metformin, canagliflozin and gliclazide in the ranges of 2.0-20.0 μg/ml, 1.5-40.0 μg/ml and 2.0-30.0 μg/ml, respectively. The RP-HPLC method produced well-resolved peaks at a retention time of 3.92, 6.92 and 9.10 min in the concentration ranges of 50.0-300.0 μg/ml, 5.0-50.0 μg/ml and 10.0-100.0 μg/ml for metformin, canagliflozin and gliclazide, respectively. The proposed methods were optimized and validated in accordance to the International Conference of Harmonisation (ICH) guidelines in terms of linearity, LOD, LOQ, precision and accuracy.
Conclusion: The developed methods were found to be sensitive and reproducible methods for the simultaneous determination of anti-diabetic binary mixtures; metformin hydrochloride-canagliflozin and metformin hydrochloride-gliclazide. And thus were successfully employed for the quality control analysis of the pharmaceutical formulations of the studied binary mixtures.
MEDICINAL PROPERTIES OF DIFFERENT PARTS OF ACACIA NILOTICA LINN (BABUL), ITS PHYTOCONSTITUENTS AND DIVERSE PHARMACOLOGICAL ACTIVITIES
Authors: SAEEDI RUSHDA , SULTANA ARSHIYA , RAHMAN KHALEEQUR 
Published: February 2020

Acacia nilotica Linn commonly known as Babul is a multipurpose tree. As the world is turning back towards the herbal drug, it is the need of the hour to re-evaluate the knowledge of traditional medicine through vast review. In the Unani traditional system of medicine, all parts of the plant have been used as a remedy for various diseases and are imputed for their medicinal properties. Hence, this review presents an overview of the medicinal properties of different parts of A. nilotica L. used in Unani medicine, its phytochemical constituents, and diverse pharmacological activities. The information related to this drug was retrieved using the classical Unani sources viz., Al-Qanun fi’l Tibb (Canon of Medicine), Iksir-i-A‘zam, Al Hawi fi’l Tibb (Continens Liber), Tarjuma Kamil al-Sana‘a al-Tibbiyya, Dhakhira Khawarizm Shahi, Biyaz-i-Kabir and Tibb-i-Akbar for medicinal properties used in Unani Medicine. Further for other traditional uses, phytoconstituents and pharmacological activities, different search engines like PubMed, Medline, Google Scholar, Ovid, Science Direct and Scopus were also browsed.
A. nilotica possesses various medicinal properties as per classical Unani texts such as astringent, tonic, wound healing, aphrodisiac, expectorant, resolvent, and antispasmodic. In vivo, in vitro, and clinical studies from the published articles validate the fact that A. nilotica is a potential source of various bioactive compounds having various pharmacological properties and therapeutic uses. The various pharmacological activities are anti-inflammatory, analgesic, antibacterial, anticancerous, antidiabetic and antihypertensive properties. This review concludes that the Unani medicinal effects of A. nilotica are proven by scientific studies.
LEAD MOLECULE IDENTIFICATION FROM VITEX TRIFOLIA LINN FOR HELMINTHIASIS USING IN VITRO AND IN SILICO METHODS
Authors: MUTHUKRISHNAN SOUNDARARAJAN , G. RAGUNATH , VARGHESE BLESSY SUSAN 
Published: February 2020

Objective: The study was an attempt to discover a lead molecule to treat helminthiasis using Vitex trifolia. Linn (V. folia Linn) through sterile effect, in vitro and in silico evaluation.
Methods: The antibacterial activity was done by Kirby-Bauer disc diffusion method in three different concentrations of extract and in vitro anthelmintic activity was carried out by petri dish and organ bath method. Further, the in silico docking studies were carried out by 11 phytoconstituents against phosphoethanolamine methyltransferase (4FGZ) using Auto Dock 4.2, it was working based on the principle of Lamarckian genetic algorithm. In docking studies, three important parameters such as binding energy, inhibition constant and intermolecular energy are determined.
Results: The extracts showed an antibacterial effect in three different concentrations. At 16 mcg/disc a significant effect was observed when compared to blank and ciprofloxacin 5 mcg/disc. The anthelmintic activity in the petri dish method, means paralyzing time of Pheretimaposthuma with the dose of 25, 50 and 100 mg/ml were 13.78, 5.79 and 4.57 min respectively and Piperazine citrate (10 mg/ml) showed paralysis in 21.58 min. In the organ bath method, the time for paralysis of the worm was recorded on a slow-moving Sherrington rotating drum and the study report showed that paralyzing time was decreased at increasing concentrations of the extract. The results of in silico studies exhibited a binding energy of-10.25kcal/mol, inhibitory constant (Ki) 30.91nM, intermolecular energy,-10.84kcal/mol for abietatriene-3-ol which is lesser than the standard ligand phosphoethanolamine (-6.03kcal/mol, 38.29µM,-7.82kcal/mol) respectively.
Conclusion: The study reports conclude that the active constituents in V. folia Linn having better anthelmintic activity, thus the active constituents may be optimized and make way to a new moiety for the treatment of helminthiasis.
<b>O DIREITO DA PERSONALIDADE À LUZ DA DECLARAÇÃO UNIVERSAL DOS DIREITOS HUMANOS</b><br/>THE RIGHT OF PERSONALITY IN THE LIGHT OF THE UNIVERSAL DECLARATION OF HUMAN RIGHTS
Authors: Siqueira Dirceu Pereira , Rostelato Telma Aparecida 
Published: February 2020

O presente artigo propende analisar a posição jurídica ocupada pelo direito da personalidade, enveredando pela abordagem histórica do tema, que veio ocupar posição de relevo, sobretudo após a segunda guerra mundial, sob o manto da asserção inovadora trazida pela Declaração Universal dos Direitos Humanos, revelando o propósito de posicionamento do homem como sendo o centro da preocupação mundial, porque transferido para o valor humano, daí sua conotação edificada ao âmbito de direitos humanos. Com o passar dos anos, passou a ostentar caráter protetivo mais abrangente e significativo, no Brasil, embora o Código Civil de 1916 não tenha a ele feito referência expressa, com o advento da Constituição vigente tornou-se viável fazer alusão aos direitos da personalidade com espeque constitucional, mormente o art. 1º., inciso III que proclama o princípio da dignidade humana, cujo préstimo se solidifica com o intento de proteção aos direitos da personalidade, perscrutando da imprescindível interpretação da magnitude da dignidade. Por certo que este empenho exegético cedeu lugar quando da entrada em vigor do Código Civil de 2002, face a adoção do constante no art. 2º. que trouxe a previsão explícita a este direito. Desse modo, deduz-se inserido no princípio da dignidade humana, o direito da personalidade que se sedimenta no aspecto físico, psíquico e moral.
KEMAMPUAN BERPIKIR TINGKAT TINGGI SISWA SMP DALAM MENYELESAIKAN SOAL MATEMATIKA MODEL PISA
Authors: Megawati Megawati , Wardani Ambarsari Kusuma , Hartatiana Hartatiana 
Published: February 2020

Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir tingkat tinggi (Higher Order Thinking Skills/HOTS) siswa dalam menyelesaikan soal matematika model PISA berdasarkan indikator kemampuan mengevaluasi. Penelitian ini adalah penelitian kualitatif dengan teknik pengumpulan data yang digunakan yaitu dokumentasi, tes, dan wawancara. Hasil penelitian menunjukkan bahsa dari 30 siswa SMP Xaverius 1 Palembang yang telah menyelesaikan soal tersebut, sebanyak 73% kemampuan berpikir tingkat tinggi siswa dikategorikan kurang khususnya pada kemampuan mengevaluasi. Indikator mengevaluasi muncul jika siswa dapat menganalisis masalah dengan baik, memahami maksud pertanyaan dengan tepat, dan memberikan alasan/bukti yang sesuai. Berdasarkan analisis jawaban siswa dan hasil wawancara dapat dikatakan bahwa dari 30 siswa, hanya 6% saja siswa dikategorikan telah mencapai tahap evaluasi dengan baik dalam menyelesaikan soal matematika model PISA.
KONFIRMASI KEBERADAAN Fasciola gigantica DAN HOSPES PERANTARA DI LINGKUNGAN PEMUKIMAN EKOSISTEM RAWA KABUPATEN HULU SUNGAI UTARA, KALIMANTAN SELATAN
Authors: Hairani Budi , Hidayat Syarif , Paisal Paisal 
Published: February 2020

Fasciola Gigantica infection occurs in swamp buffalo on livestock in the swamp area of Hulu Sungai Utara District. Geographically, the livestock area is linked to the villages of Sungai Papuyu and Kalumpang Dalam by swamp water with no barrier. Such condition allows the snail as intermediate host of F. gigantica in livestock areas easily spread to residential areas and, therefore, raises the risk of transmission to humans. This study aimed to confirm the presence of F. gigantica in the cercariae form and snails in the area around the settlement of both villages. The study was an observational study of cross-sectional design, conducted in August-December 2014 . Snail sampling was conducted at the Sungai Papuyu and Kalumpang Dalam village using hand collection method. To find cercariae in the snail crushing technique was performed. Cercariae was confirmed by means of PCR to ensure they are F. gigantica in the Laboratory of Molecular Biology, Lambung Mangkurat University, Banjarbaru. The results in both villages showed 6 genera of snail, namely Pomacea, Bellamyâ , Indoplanorbis , Lymnaea , Gyraulus and Melanoides . There are 3 types of cercariae in the snails, namely Echinostome cercariae , Brevifurcate – pharyngeate cercariae and Sulcatomicrocercous cercariae. PCR shows positive samples of F. gigantica in the Echinostome cercariae form in Lymnaea and Indoplanorbis snails. This confirms the presence of F. gigantica cercariae around the settlements area and Lymnaea and Indoplanorbis snail are the first intermediate hosts.
PERILAKU PENGGUNAAN DAN PERAWATAN KELAMBU LLINs PADA MASYARAKAT DAERAH ENDEMIS MALARIA KABUPATEN LEBAK PROVINSI BANTEN
Authors: Pratamawati Diana Andriyani , Alfiah Siti , Widiarti Widiarti 
Published: February 2020

The effectiveness of insecticide-treated nets are believed to reduce the prevalence of malaria is influenced by the behavior of people in their use , such as how to install and wash , in addition to duration of use . People's behavior can be different in each region with respect to culture , culture and ethnicity / ethnicity as a predisposing factor . The purpose of this study is to describe the behavior of people in the use of insecticide-treated nets ( LLINs ), such as the acceptance, use, washing and participation in the care of LLINs (program preservation).The study design was observational cross-sectional design. The instrument of this research is questionnaire and observation guidance of mosquito net. Samples are people with insecticide-treated nets in Lebak regency (Banten) were 81 respondents . Data were analyzed by descriptive. The results showed the level of knowledge about the use of mosquito nets in the category of " enough " (70,4 %) , with the majority being " support " the use of mosquito nets (65,4 %), and the practise of the use of mosquito nets were classified as " good " (58 %). The results also show the observation nets most respondents installing netting around the bed either owned or partially owned the bed.nowledge of the use of mosquito nets is not maximal and in the use of insecticide treated nets LLINs in a small number of respondents complained of heat and stifling, so it is necessary to evaluate the benefits of socialization activities and how to install and care of insecticide treated nets LLINs that have been done.
Evaluation of structural skeletal asymmetry of the glenoid fossa in adult patients with unilateral posterior crossbite using surface-to-surface matching on CBCT images
Authors: Muraglie Simone , Leonardi Rosalia , Aboulazm Khaled , Stumpo Chiara , Loreto Carla , Grippaudo Cristina 
Published: February 2020

ABSTRACT

Objectives
To compare, using surface-to-surface (StS) matching, any shape differences between the crossbite and noncrossbite side of the glenoid fossa and articular eminence in adult patients affected by posterior unilateral crossbite (PUXB) and compare them with unaffected controls.

Materials and Methods
32 cone beam computed tomography (CBCT) scans of patients (mean age: 23.72 ± 3.74 years) undergoing surgical maxillary expansion were analyzed to obtain three-dimensional models of the left and right glenoid fossae that were superimposed using stable anatomical reference points and then compared using StS matching to evaluate the presence of any shape differences. These findings were compared with those obtained from 16 CBCT scans of unaffected controls (mean age: 23.72 ± 3.73 years).

Results
A mean difference of &gt;11% was found between the study group and controls when comparing the matching percentages of the two sides of the glenoid fossa and articular eminence at all three levels of tolerance selected for this study. These differences were found to be highly statistically significant (P ≤ .0001).

Conclusions
According to the shape analysis findings, adult PUXB patients exhibit a higher degree of glenoid fossa and articular eminence shape differences compared to unaffected controls.
Cervicovertebral anomalies and/or normal variants in patients with congenitally bilateral absent maxillary lateral incisors:
Authors: Ozturk Taner , Atilla Aykan Onur , Yagci Ahmet 
Published: February 2020

ABSTRACT

Objective
To determine whether there is a relationship between congenitally bilaterally absent maxillary lateral incisors (BAMLIs) and skeletal anomalies and/or normal variants.

Materials and Methods
The records of 86 patients (62 girls, 24 boys; age 12–17 years) with congenitally BAMLIs and 86 patients (55 girls, 34 boys; age 13–18 years) without any dental or skeletal anomalies were collected and evaluated retrospectively. The study was based on the evaluation of lateral cephalometric and orthopantomographic radiographs. Posterior arch deficiency of the atlas bone (PADA); atlanto-occipital ligament calcification, known as “ponticulus posticus” (PP); and interclinoid ligament calcification, known as “sella turcica bridging” were recorded for each participant. Pearson χ2 and Fisher exact tests were used to evaluate and compare skeletal anomalies and/or normal variants between patients with BAMLIs and the control group.

Results
The prevalence of cervicovertebral anomalies and/or normal variants seen in the lateral cephalometric radiographs was higher in patients with BAMLI than in the control group. The prevalence of PP was lower and that of PADA was higher in patients with BAMLIs than in the control group (P &lt; .05).

Conclusion
The prevalence of PADA was increased and that of PP formation was decreased in patients with BAMLIs. There was a significant relationship between skeletal anomalies and/or normal variants.
STEM : INNOVATION IN VOCATIONAL LEARNING
Authors: Fathoni Ahmad 
Published: February 2020

AbstractIndonesia with a population of more than 200 million people, has an obligation to produce quality human resources to be able to compete with other countries. The problem currently faced is the high level of open unemployment, especially in SMK graduates. One way to improve the quality of human resources is by providing innovation in the learning process, especially in the field of vocational learning. Learning that can be applied in vocational education is learning based on STEM (Science, Technology, Engineering, and Mathematics). The purpose of this study is to describe more deeply about STEM learning as an innovative learning process that can be applied in vocational learning. The study was conducted using the literature review method of relevant research references and results, which were continued through focus group discussions (FGD). This study obtained the results of (1) STEM learning successfully applied both abroad and domestically; (2) it can improve students' creativity and critical thinking; (3) STEM learning can be integrated with learning models such as Project Based Learning, Problem Based Learning and cooperative learning; (4) Make students more confident in their future careers; and (5) STEM learning is very suitable for use in 21st century learning, especially in the vocational field so that STEM learning can be used as a solution in improving the quality of human resources and developing 21st century skills skills and in accordance with the objectives of vocational learning Keywords : STEM, Innovation, Learning, Vocational
HUKUM PELAKSANAAN SINDIKASI DENGAN LEMBAGA KEUANGAN KONVENSIONAL
Authors: Nurfitriani Nurfitriani 
Published: February 2020

The implementation of a syndicated contract between Islamic financial institutions and conventional financial institutions according to National Sharia Council – Indonesian Ulama Council (DSN-MUI) is permitted under one condition that the documents are arranged in such a way in order to avoid administrative mixture between the halal and the ribawi. Using a separated account for the two parties; make one document for Islamic financial institution and so does for conventional financial institutions, separately. In contrast to syndication by fellow Islamic financial institutions where the accounts of contract documents and other documents can be arranged in one document.
Salt tolerance of Cressa cretica and its rhizosphere microbiota
Authors: Etemadi Nematollah , Müller Maria , Etemadi Mohammad , Brandón María Gómez , Ascher-Jenull Judith , Insam Heribert 
Published: February 2020

AbstractThe dwarf shrub Cressa cretica is a thermocosmopolitan halophilic species. Different mechanisms confer salt stress tolerance such as tissue and osmotic tolerance and ion exclusion, as well as the associated microbiota. The aims were (i) to investigate the best conditions for C. cretica seed germination and to examine the tolerance of germinated seeds and seedlings to different salt concentrations and (ii) to characterize the rhizosphere and bulk soil microbiota. Germination and growth experiments were conducted to address plant salt tolerance, and with Illumina sequencing the microbiota of rhizosphere and bulk soil was investigated. While high salt concentrations (600, 800, and 1000 mM NaCl) inhibited C.cretica seed germination, recovery of ungerminated seeds under non-saline conditions was high, indicating osmotic rather than toxic effects of high salt concentrations. The microbiota found in rhizosphere and bulk soil showed high similarity with that found in previous studies on halophyte-associated microbiota, among the Planctomyces, Halomonas and Jeotgalibacillus. Concluding, salt stress responses on the plant level were shown, as has the involvement of associated halotolerant bacteria. Still, the potential role for mitigating saline stress by the bacterial associates of C. cretica, most of them microbial dark matter, will have to be investigated, as will the contributions of archaea and fungi.
Ultrasonic Cleaner Berbasis Field Programable Gate Array (FPGA)
Authors: Zubair Achmad , Achmad Andani , Samman Faizal Arya 
Published: February 2020

Pada penelitian ini dibuat pembangkit pulsa ultrasonik dengan menggunakan teknologi FPGA dengan type chip Altera Cyclone IV EP4CE22F17C6N. Pembangkit pulsa ultrasonic sangat diperlukan untuk inspeksi tak merusak menggunakan karena memiliki kelebihan jika dibandingkan dengan sumber radiasi lain, diantaranya: portable (bisa dibawa ke mana-mana), bahaya radiasi kecil, harga relatif murah, lebih banyak data fisis yang diperoleh, dan penggunaan energi pencatu daya kecil. Tigggi pulsa dan frekuensi gelombang ultrasonik yang diradiasikan pada obyek disesuaikan dengan material yang di radiasi. Pada medium gas diperlukan tegangan pulsa 20 volt, sedangkan untuk material padat ketinggian pulsa pembangkit ultrasonik hingga 350 volt. Lebar pulsa ultrasonik dibangkitkan melalui bahasa pemrograman assembly mikrokontroler tersebut. Pulsa keluaran dikuatkan menggunakan IC Optocoupler agar memperoleh taraf arus yang cukup untuk memicu rangkaian MOSFET IRF832. Rangkaian saklar MOSFET digunakan untuk membangkitkan pulsa tegangan tinggi dan tegangan keluarannya dapat divariasi dari resistor yang dipasang pada kaki Drain. Dari penelitian yang dilakukan diperoleh variasi lebar pulsa yang dapat diatur melalui prosedur permrograman tunda dengan frekuensi keluaran 33 KHz – 48 KHz. Dari hasil pengujian kestabilan pulsa diperoleh nilai kestabilan 99,89% pada lebar 1 us dan 99,07 % pada lebar pulsa 250 ns. Tegangan tinggi pulsa dapat diatur dari 36,8 volt hingga 354,8 volt melalui resistor Drain (RD) dari MOSFET IRF832 yang digunakan. Nilai resitansi dari resistor RD yang digunakan tersebut berada pada kisaran 10Ω hingga 470kΩ. Pulsa yang dihasilkan pada rangkaian tersebut dapat menembus material padat yang digunakan sebagai bahan uji.