bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women
Authors: Ahmadi-Motamayel Fatemeh , Fathi Shima , Goodarzi Mohammad Taghi , Borzouei Shiva , Poorolajal Jalal , Barakian Yasamin 
Published: October 2020

Background:
One of the most common complications of pregnant women is gestational
diabetes mellitus (GDM). Oxidative stress can play an important role in GDM.

Objective:
The aim of this study was to evaluate salivary antioxidants and oxidative stress markers
in GDM.

Methods:
Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood
glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric
assay was carried out for sialo-chemical analysis. Stata software was used for data
analysis.

Results:
The GDM group exhibited no significant difference in salivary total antioxidant capacity
and malondialdehyde compared to the healthy control group. All antioxidants markers, the uric
acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase
and catalase was statistically significant. All of oxidative stress markers, the salivary
malondialdehyde, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited
significantly higher salivary total oxidative stress levels.

Conclusion:
Catalase level was significantly lower and total oxidative stress was significantly higher.
These two markers might have significant importance and might exhibit early changes compared
to other factors in GDM. Some salivary antioxidants might have diagnostic, prognostic or
therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples
need to be done to confirm these properties and salivary samples using instead of blood samples
in GDM biomarkers changes.
Design, Synthesis and In Vitro Evaluation of 4-Oxo-6-Substituted Phenyl- 2-Thioxo1,2,3,4-Tetrahydropyrimidine-5-Carbonitrile Derivatives as HIV Integrase Strand Transfer Inhibitors
Authors: Wadhwa Pankaj , Jain Priti , Jadhav Hemant R. 
Published: October 2020

Aim::
To design, synthesis and in vitro evaluation of 4-oxo-6-substituted phenyl-2-
thioxo1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives as HIV integrase strand transfer
inhibitors.

Background::
Human immunodeficiency virus-1 (HIV-1), a member of retroviridae family, is the
primary causative agent of acquired immunodeficiency syndrome (AIDS). Three enzymes viz: integrase
(IN), reverse transcriptase (RT) and protease play important role in its replication cycle. HIV-1
integrase is responsible for the incorporation of viral DNA into human chromosomal DNA by catalyzing
two independent reactions, 3′-processing (3′-P) and strand transfer (ST), which are observed
as the “point of no-return” in HIV infection.

Objective::
To develop inhibitors against HIV integrase strand transfer step.

Methods::
Our previous results indicated that tetrahydro pyrimidine-5-carboxamide derivatives are
potent HIV-1 IN inhibitors (unpublished results from our laboratory). Taking clue from above studies
and our own experience, we hypothesized 4-oxo-6-substituted phenyl-2-thioxo1,2,3,4-
tetrahydropyrimidine-5-carbonitrile analogues (14a to 14n) as inhibitors of HIV-1 Integrase strand
transfer. Prototype compound 14 can be viewed as hybrid structure having characteristics of dihydropyrimidine
derivatives 10-12 and tyrphostin 13.

Result::
A total of fourteen derivatives of 4-oxo-6-substituted phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-
5-carbonitrile (14a-14n) were synthesized and evaluated using HIV-1 Integrase Assay
Kit (Xpressbio Life Science Products, USA). The percentage inhibition of all compounds was investigated
at 10 μM concentration and IC50 value of few highly active compounds was studied. The
obtained results were validated by in silico molecular docking study using Glide (maestro version
9.3, Schrödinger suite) in extra precision (XP) mode.

Conclusion::
Fourteen 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile
analogues were synthesized and evaluated for HIV-1 IN inhibitory activity. Three compounds 14a,
14e, and 14h exhibited significant percentage inhibition of HIV-1 IN. There was good in vitro - in
silico correlation. However, none of the derivative was active against HIV-1 and HIV-2 below their
cytotoxic concentration. It needs to be seen whether these compounds can be explored further for
their anti-HIV or cytotoxic potential.
Synthesis and Docking Study of Some Bioactive N-(benzo[d]thiazol-2-yl)- 2-(4-((substituted)phenoxy)acetamide on Cyclo-oxygenase-2 Enzyme and In vivo Analgesic Activity Evaluation
Authors: Kumar Sumit , Kumar Arvind , Verma Amit , Mishra Arun Kumar 
Published: October 2020

Background::The benzothiazole and its derivatives reported an extremely crucial duty in the progress of commercially important intermediary molecules, which are wanted for the manufacturing of various pharmacologically active agents.Introduction::As a necessary element of ongoing examination for the synthesis of new nonsteroidal anti-inflammatory agents (NSAIDs), a number of new benzothiazole derivatives were taken under consideration for the synthesis and were computationally studied along with their biological activity.Methods::Obtainable benzothiazole derivatives were synthesized by the condensing of 2-(4- aminophenoxy)-N-(benzo[d]thiazol-2-yl)acetamide with substituted acetophenones in ethanol in the presence of a catalytic amount of glacial acetic acid. The structures of newly synthesized compounds were characterized by IR, NMR spectroscopy and elemental analysis techniques. Several molecular properties of these derivatives were computed in order to estimate their drug like candidates. Molecular docking was performed to these synthesized derivatives with particular reference to cyclooxygenase-2 (COX-2) enzyme. The synthesized derivatives were screened for their biological activity, including analgesic and anti-inflammatory activity as COX-2 inhibitors.Results and Discussion::From all data, it established that among all target compounds, S-4 (N-(benzo[d]thiazol- 2-yl)-2-(4-((1-(3-nitrophenyl)ethylidene)amino)phenoxy)acetamide) displayed the highest antiinflammatory and analgesic effects.Conclusion::All these findings recommended that S-4 might be utilized as a promising new lead compound for Nonsteroidal anti-inflammatory drug (NSAIDs) development.
COVID-19 and Infection Control in Dental Clinics; Assessment of Public Knowledge, Attitudes and Practices in Several Regions of Saudi Arabia
Authors: Rajeh Mona 
Published: October 2020

Background:
The recent outbreak of the Corona Virus Disease (COVID-19) has affected millions of lives in different countries including the Kingdom of Saudi Arabia. Due to the characteristics of dental practice settings, there is a high risk of infection transmission between patients and dentists.

Objectives:
The aim of this study was to assess the level of public knowledge, attitude and practice regarding COVID-19 and infection control when visiting a dentist.

Methods:
In April 2020, a web-based cross-sectional survey was distributed randomly among the public through social media platforms. A validated anonymous questionnaire was used to assess knowledge about COVID-19 and participants’ attitudes toward extra measures to prevent the spread of infection.

Results:
Among the completed questionnaires (N=521), the mean age of the participants was 36.24 years, 68.3% were women, 87.5% held a university degree, and 81% were from the Makkah region. Most of the participants (99%) obtained a good knowledge score regarding COVID-19. Women were more likely than men to have more knowledge (p<0.05). Nearly all of the participants (99.6%) demonstrated good attitudes towards precautionary measures in dental clinics.
Spearman’s rho test showed a statistically significant correlation between age and attitude score, suggesting that attitude score increased with age (p<0.05). Overall, 73.3% reported that they would maintain good hygiene practices when visiting a dentist during this pandemic.

Conclusion:
Most Saudi residents with a high education level are knowledgeable about COVID-19, hold promising attitudes, and have appropriate practices towards precautionary measures needed while visiting a dental clinic during the virus outbreak.
Successful Non-surgical Management of a Mandible Fracture Secondary to Medication-related Osteonecrosis of the Jaw: A Unique Case Report
Authors: Bennardo Francesco , Buffone Caterina , Fortunato Leonzio , Giudice Amerigo 
Published: October 2020

Background: Medication-related osteonecrosis of the jaw (MRONJ) may be a severe side effect of bone-modifying agents.

Objective: Pathologic fractures treatment in patients with MRONJ remains challenging. The authors reported a unique case of successful non-surgical management of a mandible fracture secondary to MRONJ.

Methods: A 78-year-old osteoporotic woman with a 4-year history of oral bisphosphonate therapy and a compromised dental condition developed an MRONJ-related right mandibular body fracture. Treatment consisted of systemic antibiotic administration (amoxiclav and metronidazole) and chlorhexidine mouthwash.

Results: Follow-up visits revealed progressive healing of the mandibular fracture with bone callus formation and complete recovery of the ipsilateral lip and chin sensitivity after one year.

Conclusion: Non-surgical management of pathological fractures related to MRONJ might be of interest in patients that refuse any type of surgery, but preventive measures, such as careful dental examination, should be taken before start antiresorptive therapy and during the treatment. The authors reported the first case in the literature of successful management of a mandibular fracture secondary to MRONJ with only antibiotics and mouthwashes.
The Method and Simulation Model of Element Base Selection for Protection System Synthesis and Data Transmission
Authors: Tsmots Ivan , Teslyuk Vasyl , Teslyuk Taras , Lukashchuk Yurii 
Published: October 2020

Background:
The modern stage of the development data protection and transmission systems is characterized by an extension of the application areas, most of which require encryption (decryption) and encoding (decoding) in real time on hardware that satisfy the restrictions on the dimensions, energy, cost and development time. In this connection, the problem of choosing an elemental base for the synthesis of neuro-like structures of symmetric encryption-decryption of data and means of encoding-decoding when transmitting data using noise-like codes becomes especially relevant.

Methods:
Software implementation of data protection and transmission using noise-like codes involves the use of universal and functionally oriented microprocessors. In the programmatic implementation of neuro-like algorithms for encryption and decryption of data, computational processes are mostly expandable in time with a large volume of information transfer between the RAM and operating devices.

Results:
In this work were performed series of element base selection simulations and synthesis of DPTS, with various technical parameters. During each simulation, the microcontroller, memory blocks, operating nodes and communication interfaces are selected. The simulation was performed on a MacBook Pro 2015 with a Core i7 processor and 16 GB of RAM.

Conclusion:
It has been proposed to implement the real-time DPTS using noise-like codes by combining universal and special approaches based on the processor core supplemented by hardware with a table-algorithmic implementation of encryption (decryption) processes. The method of selection of the elemental base for synthesis of DPTS has been improved. A simulation model of element base selection for the synthesis of the DPTS has been developed. The system of synthesis of data protection and data transmission using noise-like codes has been developed.
Stress Tracker—Detecting Acute Stress From a Trackpad: Controlled Study
Authors: Goel Rahul , An Michael , Alayrangues Hugo , Koneshloo Amirhossein , Lincoln Emmanuel Thierry , Paredes Pablo Enrique 
Published: October 2020

Background
Stress is a risk factor associated with physiological and mental health problems. Unobtrusive, continuous stress sensing would enable precision health monitoring and proactive interventions, but current sensing methods are often inconvenient, expensive, or suffer from limited adherence. Prior work has shown the possibility to detect acute stress using biomechanical models derived from passive logging of computer input devices.

Objective
Our objective is to detect acute stress from passive movement measurements of everyday interactions on a laptop trackpad: (1) click, (2) steer, and (3) drag and drop.

Methods
We built upon previous work, detecting acute stress through the biomechanical analyses of canonical computer mouse interactions and extended it to study similar interactions with the trackpad. A total of 18 participants carried out 40 trials each of three different types of movement—(1) click, (2) steer, and (3) drag and drop—under both relaxed and stressed conditions.

Results
The mean and SD of the contact area under the finger were higher when clicking trials were performed under stressed versus relaxed conditions (mean area: P=.009, effect size=0.76; SD area: P=.01, effect size=0.69). Further, our results show that as little as 4 clicks on a trackpad can be used to detect binary levels of acute stress (ie, whether it is present or not).

Conclusions
We present evidence that scalable, inexpensive, and unobtrusive stress sensing can be done via repurposing passive monitoring of computer trackpad usage.
The Formation of Students’ Values in the Context of Changes in the Educational Environment (On the Example of the Leningrad Region)
Authors: Klyuev A. V. , Lyashko S. V. 
Published: October 2020

The article examines the direction of improving the quality level of the educational process in the conditions of changing educational environment and new social challenges. One of the important aspects in the conditions of innovative transformations is the formation of students ‘ social and spiritual values. It is the General education school that should form in the minds of the younger generation spiritual, moral and Patriotic values, social and ethical norms of behavior based on national and universal ideals.The study of students ‘own value preferences is insufficient from the point of view of methodological educational and organizational approaches.in this regard, students’ value orientations and preferences often remain outside the field of view of the pedagogical community.The article notes that a comprehensive analysis of the formation of values of high school students, the study of the mechanisms of intergenerational continuity and the development of innovative forms of educational influence important study of value preferences of students, as well as the evaluation opinions of the teaching staff, especially young teachers engaged in the educational process. The purpose of this article is also to study the trends and specifics of the educational and educational process focused on the problems and formation of social values of students of educational organizations in the Leningrad region.
Ráfagas de aire, formas de habitar los sitios de memoria. Muestra de fotografías en el Museo de Arte y Memoria (MAM) de La Plata
Authors: Jean Jean Melina , Basso Florencia 
Published: October 2020

El 29 de junio de 2011 se sancionó en Argentina la Ley Nacional 26.691 que declara Sitios de Memoria a los lugares que funcionaron como centros clandestinos de detención, tortura y exterminio (CCDTyE) o donde sucedieron hechos emblemáticos del accionar de la represión ilegal desarrollada durante el terrorismo de Estado ejercido en el país hasta el 10 de diciembre de 1983. Como autoridad de aplicación, la Secretaría de Derechos Humanos de la Nación a través de la Dirección Nacional de Sitios de Memoria reglamentó la Ley en el 2014 y se comprometió a garantizar la preservación, señalización y difusión de los sitios, así como también su gestión, y la promoción y asistencia de proyectos de nuevos espacios de memoria. De esta forma, se consolidó el trabajo interjurisdiccional que se venía desarrollando desde la Red Federal de Sitios de Memoria, creada en el 2006 en la órbita del Archivo Nacional de la Memoria.
Pengaruh Model Pembelajaran Kooperatif Tipe Student Team Achievement Division (STAD) Terhadap Kemampuan Berpikir Kritis Siswa (Studi Eksperimen pada Mata Pelajaran Ekonomi Kelas XI SMA Informatika Ciamis)
Authors: Arifin Nur Rizqi 
Published: October 2020

Berdasarkan hasil observasi awal diperoleh gambaran mengenai rendahnya kemampuan berfikir kritis siswa yang dilihat dari hasil analisis butir soal yang dianggap sukar khususnya mata pelajaran ekonomi menunjukan bahwa jumlah siswa yang mampu mencapai nilai Kriteria Ketuntasan Minimal (KKM) hanya 23 orang atau 38,33% sedangkan siswa yang mendapat nilai dibawah KKM sebanyak 37 orang atau 61,66%. Perolehan nilai tersebut merupakan implikasi dari perilaku siswa pada saat proses pembelajaran. Para siswa gelisah, mengantuk, apatis, tidak bertanya meskipun guru memberi kesempatan kepada siswa untuk bertanya dan sebagian besar tidak bisa menjawab pertanyaan mengenai isi materi yang baru disampaikan. Pada saat evaluasi kebanyakan siswa tidak mampu menjawab soal yang menuntut berfikir kritis. Metode penelitian yang digunakan dalam penelitian ini adalah eksperimen yang merupakan jenis penelitian kuantitatif. Metode ini digunakan dengan cara menguji kemampuan berfikir kritis siswa dengan menggunakan Model Pembelajaran Kooperatif Tipe Student Team Achievement Division (STAD). Untuk melihat pengaruh peningkatan kemampuan berpikir kritis siswa pada mata pelajaran ekonomi, siswa diberikan perlakuan berupa pretests dan posttest. Adapun desain eksperimennya adalah Nonequevalent Control Group Design. Hasil penelitian menunjukkan bahwa terdapat perbedaan kemampuan berpikir kritis siswa pada pengukuran awal (pretest) dengan pengukuran akhir (posttest) sebesar 31,333 pada kelas eksperimen yang menggunakan Model Pembelajaran Kooperatif Tipe Student Team Achievement Division (STAD). Nilai rata-rata kelas kontrol sedikit lebih rendah dari pada nilai rata-rata kelas eksperimen, perbedaan rata-rata (mean diference) sebesar 1,000 (72.67-71,67) dan perbedaan berkisar antara -5,581 sampai -7,581 terlihat pada lower dan upper. Terlihat bahwa nilai signifikansi kelas eksperimen dan kontrol pada pengujian posttest sebesar 0,762 disini membuktikan bahwa tidak terdapat pengaruh yang signifikan terhadap kemampuan berpikir kritis siswa pada pembelajaran ekonomi dengan uji t. Karena nilai probabilitasnya lebih kecil P value 0,762 < 0,05 maka H0 diterima dan H1 ditolak yang berarti bahwa tidak terdapat perbedaan signifikan antara rata-rata nilai posttest eksperimen dengan rata-rata nilai posttest kontrol. Peneliti memberikan saran kepada guru yang akan menerapkan Model Pembelajaran Kooperatif Tipe STAD perlu pemahaman konsep dan keterampilan menggunakan model dan metode secara lebih komprehensif Kata Kunci: Model pembelajaran dan Berpikir kritis
Pemaknaan Simile oleh Mahasiswa UIN Raden Intan Lampung
Authors: Yoga Irawan Annisa Fitriani 
Published: October 2020

Problems in this research was the extent to which understanding students to majas similes. This study aims to described purport and forms majas similes. Methods used in research this is the method descriptive qualitative with the data on an interpretation majas similes by college students. Data collection techniques in this study are documentation. Data analysis techniques by classifying data, interpreting data, explaining data, concluding temporarily, conducting internal and external triangulation, and making final conclusions.The research results show the first phase students the handling each of words that form said similes. The next stage students the handling said similes whole. Words similes who seen by students can divided into three categories similes. The third words similes, namely similes category nature, man, and dead objects AbstrakPermasalahan dalam penelitian ini adalah sejauh mana pemahaman mahasiswa terhadap majas simile. Penelitian ini bertujuan untuk mendeskripsikan pemaknaan dan bentuk-bentuk majas simile. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan data yang berdasarkan interpretasi majas simile oleh mahasiswa. Teknik pengumpulan data dalam penelitian ini adalah dokumentasi. Teknik analisis data dengan cara mengklasifikasi data, menafsirkan data, menjelaskan data, menyimpulkan sementara, melakukan triangulasi internal dan eksternal, dan membuat simpulan akhir. Hasil penelitian menunjukkan tahap pertama mahasiswa memaknai masing-masing kata yang membentuk kata simile. Tahap selanjutnya mahasiswa memaknai kata simile secara utuh. Kata-kata simile yang dimaknai oleh mahasiswa dapat dibagi ke dalam tiga kategori simile. Ketiga kata simile tersebut, yaitu simile kategori alam, manusia, dan benda mati.
Perian Semantik Leksem Alat-Alat Pengolah Sagu dalam Bahasa Sentani, Papua
Authors: Normawati Normawati 
Published: October 2020

Sagoo is a kind of staple food for people in eastern Indonesia. This short writing makes an effort to study any various semantical lexeme of sagoo processing tools in Sentani language, Papua. The stage of this research consist of collecting data, analyzing data and presenting data analysis. Then, she got oral and written data for this research. Those data, then, has been analyzed using analysis of lexical components method by several phase. First, selecting data to determine any meaning class which is mutually collocated and presumed to form a specific domain. Second, determine contiguity relationship intersense in several lexemes. Analysis result shows that various semantical lexeme in Sentani language for these tools are eleven lexemes. Those are classified into three groups. They are (1) tools or equipment for cutting sago tree, (2) tools for pounding, and (3) tools for squeezing sagoo. Subdomain meaning of ‘tools for cutting sagoo tree’ lexemes are devided into three, namely, ramayali ‘machete’, ramekahu ‘axe’, and onggi ‘crowbar’. AbstrakSagu bagi orang Indonesia Timur merupakan salah satu makanan pokok. Tulisan ringkas ini berupaya mengkaji varian semantik leksem alat-alat pengolah sagu dalam bahasa Sentani, Kabupaten Jayapura, Papua. Langkah kerja penelitian ini, meliputi pengumpulan data, pengolahan data, dan pemaparan hasil pengolahan data. Data diperoleh dari data lisan dan data tertulis. Data yang telah terkumpul kemudian dianalisis dengan menerapkan metode analisis komponen leksikal dengan langkah-langkah berikut. Pertama, menyeleksi data untuk menentukan kelompok makna saling berkolokasi yang diperkirakan membentuk satu medan makna tertentu. Kedua, menentukan hubungan kontinguitas antarmakna yang terdapat dalam sejumlah leksem. Hasil analisis menunjukkan bahwa varian semantik leksem alat-alat pengolah sagu dalam bahasa Sentani berjumlah sebelas leksem. Leksem-leksem tersebut diklasifikasikan ke dalam tiga kelompok, yaitu (1) peralatan dalam menebang sagu, (2) peralatan dalam proses menokok sagu, dan (3) peralatan dalam proses meramas sagu.