bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Material Model and Aortic Root Motion in Finite Element Analysis of Two Exemplary Cases of Proximal Aortic Dissection
Authors: Subramaniam Dhananjay Radhakrishnan , Gutmark Ephraim , Andersen Niels , Nielsen Dorte , Mortensen Kristian , Gravholt Claus , Backeljauw Philippe , Gutmark-Little Iris 
Published: August 2020

Abstract
The risk of type-A dissection is increased in subjects with connective tissue disorders and dilatation of the proximal aorta. The location and extents of vessel wall tears in these patients could be potentially missed during prospective imaging studies. The objective of this study is to estimate the distribution of systolic wall stress in two exemplary cases of proximal dissection using finite element analysis (FEA) and evaluate the sensitivity of the distribution to the choice of anisotropic material model and root motion. FEA was performed for predissection aortas, without prior knowledge of the origin and extents of vessel wall tear. The stress distribution was evaluated along the wall tear in the postdissection aortas. The stress distribution was compared for the Fung and Holzapfel models with and without root motion. For the subject with spiral dissection, peak stress coincided with the origin of the tear in the sinotubular junction. For the case with root dissection, maximum stress was obtained at the distal end of the tear. The FEA predicted tear pressure was 20% higher for the subject with root dissection as compared to the case with spiral dissection. The predicted tear pressure was higher (9–11%) for root motions up to 10 mm. The Holzapfel model predicted a tear pressure that was lower (8–15%) than the Fung model. The FEA results showed that both material response and root motion could potentially influence the predicted dissection pressure of the proximal aorta at least for conditions tested in this study.
Wettability Effects on Falling Film Flow and Heat Transfer Over Horizontal Tubes in Jet Flow Mode
Authors: Karmakar Avijit , Acharya Sumanta 
Published: August 2020

Abstract
The performance of a falling-film heat exchanger is strongly linked to the surface characteristics and the heat transfer processes that take place over the tubes. The primary aim of this numerical study is to characterize the influence of surface wettability on the film flow behavior and its associated surface heat transfer in the jet-flow mode. Volume of fluid (VOF) based simulations are carried out for horizontal tubes with different surface wettabilities. The wettability of the tube surfaces is represented using the Kistler's dynamic contact angle model. Surface wettability effects ranging from superhydrophilic to superhydrophobic are studied by varying the equilibrium contact angle from 2 deg to 175 deg. Two different liquid mass flow rates of 0.06 and 0.18 kg/m-s corresponding to the inline and staggered jet flow modes are studied. Results are presented in terms of the liquid film thickness, the contact areas between the different phases (solid–liquid and liquid–air), and the heat transfer coefficient or Nusselt number. The resistance imposed by the increasing contact angles inhibits the extent of the liquid spreading over the tube surface, and this, in turn, influences the liquid film thickness, and the wetted area of the tube surface. A significant decrement in the heat transfer rate from the tube surfaces was observed as the equilibrium contact angle increased from 2 deg to 175 deg. The local distributions of the Nusselt number over the tube surface are strongly influenced by the flow recirculation in the liquid bulk.
Instantaneous Optical Measurement of the Temperature at the Interface Between a Wall and a Thin Liquid Film
Authors: Fehring Brian E. , Morse Roman W. , Chan Jason , Dressler Kristofer M. , Hurlburt Evan T. , Nellis Gregory F. , Berson Arganthaël 
Published: August 2020

Abstract
Instantaneous temperature measurements at the interface between a solid wall and a thin, unsteady liquid film are performed using thermoreflectance, a nonintrusive optical technique with high temporal resolution. A laser beam is directed at a wall–liquid interface, and the intensity of the light reflected at that interface is measured by a photodiode. The intensity of the reflected light varies with the index of refraction of the liquid at the wall. The index of refraction is a function of temperature, which enables the instantaneous measurement of the wall temperature. In the presence of thin liquid films, reflections from the liquid–vapor interface at the free surface of the film generate noise in the measurements. We demonstrate that orienting the laser beam at a large incident angle, close to total internal reflection, minimizes noise from the liquid–vapor interface while increasing the sensitivity of the measurement. The thermoreflectance technique is validated in an unsteady two-phase annular flow. Measurements of temperature fluctuations less than 1 K in amplitude are achieved, with an uncertainty of 0.1 K.
Experimental Flow-Induced Vibration Analysis of the Crossflow Past a Single Cylinder and Pairs of Cylinders in Tandem and Side-by-Side
Authors: Neumeister Roberta Fátima , Petry Adriane Prisco , Möller Sergio Viçosa 
Published: August 2020

Abstract
Flow-induced vibration of a single cylinder and two cylinders in tandem and side-by-side configurations is experimentally investigated in this paper in the subcritical regime. The natural frequency of the system varied from 8.8 Hz to 46.2 Hz. The mass ratio, m*, ranged between 158 and 643 while the damping ratio, ζ, between 0.0005 and 0.009. The pairs of cylinders present a spacing ratio of 1.26 (P/D and L/D). In all cases, one and both cylinders (BV) were free to vibrate. Experiments were performed in an aerodynamic channel with a constant height and a variable width, for the evaluation of the influence of the blockage ratio (BR), using accelerometers and hot wire anemometry. The reference velocity, measured at the entrance of the test section was used to calculate the reduced velocity, Vr = U/fnD, with values from 4 to 132 and the Reynolds number between 3 × 103 and 8 × 104. The root-mean-square-values of the displacement amplitudes, Y/D, were obtained through the integration of the acceleration signals. Fourier and continuous wavelets were employed in the analysis. For a single cylinder free to vibrate, the higher amplitudes occur at two distinct reduced velocities, associated with the vibration modes of the cylinder. The vibration amplitude of a single cylinder increased as the blockage ratio increased, decreasing for the highest blockage ratio investigated. For the case of cylinders in tandem, the presence of the fixed cylinder in the wake of the cylinder free to vibrate amplifies the vibration response at high reduced velocities. When the blockage ratio is increased, a sudden increase in the vibration amplitude is observed. When both cylinders are free to vibrate, the relation between the natural frequencies of both cylinders influences the response amplitudes. In the case with two cylinders side-by-side, the vibration amplitude remains similar to a single cylinder, but when both cylinders are free to vibrate, the presence and the influence of flow bistability is observed.
Vorticity Shedding and Acoustic Resonance Excitation of Two Tandem Spirally Finned Cylinders in Cross-Flow
Authors: Alziadeh Mohammed , Mohany Atef 
Published: August 2020

Abstract
The aeroacoustic response of two tandem spirally finned cylinders is experimentally investigated. Three different pairs of finned cylinders are studied with fin pitch-to-root diameter ratios (p/Dr) ranging between 0.37≤p/Dr≤0.74. The spiral fins are crimped similar to those used in industrial heat exchangers. The results of the finned cylinders are compared with bare, circular cylinders with a modified equivalent diameter (Deq). The spacing ratio (L/Deq) between the cylinders are kept constant at L/Deq=2.00. The Strouhal number (StDeq) of the tandem finned cylinders is found to be higher compared to the tandem bare cylinders, resulting in an earlier onset of coincidence resonance. Moreover, unlike the tandem bare cylinders, the Strouhal number of the finned cylinders did not depend on the Reynolds number, suggesting that the flow characteristics around the finned cylinders are unaffected by Reynolds number. Only the tandem finned cylinders with the lowest fin pitch-to-root diameter ratio (p/Dr=0.37) were capable of exciting precoincidence acoustic resonance. The precoincidence resonance mechanism is similar to that observed in in-line tube bundles.
Application of Probabilistic Fracture Mechanics to Reactor Pressure Vessel Using PASCAL4 Code
Authors: Lu Kai , Katsuyama Jinya , Li Yinsheng , Yoshimura Shinobu 
Published: August 2020

Abstract
Probabilistic fracture mechanics (PFM) is considered to be a promising methodology in structural integrity assessments of pressure-boundary components in nuclear power plants since it can rationally represent the inherent probabilistic distributions for influence parameters without over-conservativeness. To strengthen the applicability of PFM methodology in Japan, Japan Atomic Energy Agency has developed a PFM analysis code PASCAL4 which enables the failure frequency evaluation of reactor pressure vessels (RPVs) considering neutron irradiation embrittlement and thermal transients. PASCAL4 is expected to make a significant contribution to the probabilistic integrity assessment of Japanese RPVs. In this study, PFM analysis for a Japanese model RPV in a pressurized water reactor (PWR) was conducted using PASCAL4, and the effects of nondestructive examination (NDE) and neutron flux reduction on failure frequencies of the RPV were quantitatively evaluated. From the analysis results, it is concluded that PASCAL4 is useful for probabilistic integrity assessments of embrittled RPVs and can enhance the applicability of PFM methodology.
Anatomy of a crustal-scale accretionary complex: Insights from deep seismic sounding of the onshore western Makran subduction zone, Iran
Authors: Haberland Christian , Mokhtari Mohammad , Babaei Hassan Ali , Ryberg Trond , Masoodi Mehdi , Partabian Abdolreza , Lauterjung Jörn 
Published: August 2020

Abstract
The Makran subduction zone has produced M 8+ earthquakes and subsequent tsunamis in historic times, hence indicating high risk for the coastal regions of southern Iran, Pakistan, and neighboring countries. Besides this, the Makran subduction zone is an end-member subduction zone featuring extreme properties, with one of the largest sediment inputs and the widest accretionary wedge on Earth. While surface geology and shallow structure of the offshore wedge have been relatively well studied, primary information on the deeper structure of the onshore part is largely absent. We present three crustal-scale, trench-perpendicular, deep seismic sounding profiles crossing the subaerial part of the accretionary wedge of the western Makran subduction zone in Iran. P-wave travel-time tomography based on a Monte Carlo Markov chain algorithm as well as the migration of automatic line drawings of wide-angle reflections reveal the crustal structure of the wedge and geometry of the subducting oceanic plate at high resolution. The images shed light on the accretionary processes, in particular the generation of continental crust by basal accretion, and provide vital basic information for hazard assessment and tsunami modeling.
An analysis of clinical predictive values for radiographic pneumonia in children
Authors: Rees Chris A , Basnet Sudha , Gentile Angela , Gessner Bradford D , Kartasasmita Cissy B , Lucero Marilla , Martinez Luis , O'Grady Kerry-Ann F , Ruvinsky Raul O , Turner Claudia , Campbell Harry , Nair Harish , Falconer Jennifer , Williams Linda J , Horne Margaret , Strand Tor , Nisar Yasir B , Qazi Shamim A , Neuman Mark I 
Published: August 2020

IntroductionHealthcare providers in resource-limited settings rely on the presence of tachypnoea and chest indrawing to establish a diagnosis of pneumonia in children. We aimed to determine the test characteristics of commonly assessed signs and symptoms for the radiographic diagnosis of pneumonia in children 0–59 months of age.MethodsWe conducted an analysis using patient-level pooled data from 41 shared datasets of paediatric pneumonia. We included hospital-based studies in which >80% of children had chest radiography performed. Primary endpoint pneumonia (presence of dense opacity occupying a portion or entire lobe of the lung or presence of pleural effusion on chest radiograph) was used as the reference criterion radiographic standard. We assessed the sensitivity, specificity, and likelihood ratios for clinical findings, and combinations of findings, for the diagnosis of primary endpoint pneumonia among children 0–59 months of age.ResultsTen studies met inclusion criteria comprising 15 029 children; 24.9% (n=3743) had radiographic pneumonia. The presence of age-based tachypnoea demonstrated a sensitivity of 0.92 and a specificity of 0.22 while lower chest indrawing revealed a sensitivity of 0.74 and specificity of 0.15 for the diagnosis of radiographic pneumonia. The sensitivity and specificity for oxygen saturation <90% was 0.40 and 0.67, respectively, and was 0.17 and 0.88 for oxygen saturation <85%. Specificity was improved when individual clinical factors such as tachypnoea, fever and hypoxaemia were combined, however, the sensitivity was lower.ConclusionsNo single sign or symptom was strongly associated with radiographic primary end point pneumonia in children. Performance characteristics were improved by combining individual signs and symptoms.
Creating the Moorfields’ virtual eye casualty: video consultations to provide emergency teleophthalmology care during and beyond the COVID-19 pandemic
Authors: Kilduff Caroline LS , Thomas Alice AP , Dugdill Juliet , Casswell Edward J , Dabrowski Marcin , Lovegrove Claire , Sim Dawn A , Hay Gordon R , Thomas Peter BM 
Published: August 2020

BackgroundThe COVID-19 crisis forced hospitals in the UK dramatically to reduce outpatient activity. To provide continuity of care and to assist patients reluctant or unable to leave their homes, video consultations were rapidly implemented across routine and emergency ophthalmology services.ObjectiveTo describe the deployment and scaling to a large volume of teleophthalmology using a video consultation platform ‘Attend Anywhere’ in Moorfields Eye Hospital’s accident and emergency (A&E) department (London, UK).MethodPatient satisfaction, waiting time, consultation duration, outcome and management were audited following the launch of the new virtual A&E service.ResultsIn the 12 days following the service launch, 331 patients were seen by video consultation. 78.6% of patients (n=260) were determined not to need hospital A&E review and were managed with advice (n=126), remote prescription (n=57), general practitioner referral (n=27), direct referral to hospital subspecialty services (n=26) or diversion to a local eye unit (n=24). Mean patient satisfaction was 4.9 of 5.0 (n=62). The mean consultation duration was 12 min (range 5–31 min) and the wait time was 6 min (range 0–37 min).ConclusionVideo consultations showed greater than expected usefulness in the remote management of eye disease and supported a substantial reduction in the number of people visiting the hospital.
Simulation capacity building in rural Indian hospitals: a 1-year follow-up
qualitative analysis
Authors: Sheshadri Veena , Wasserman Isaac , Peters Alexander W , Santhirapala Vatshalan , Mitra Shivani , Sandler Simone , Svensson Emma , Ljungman David , George Regi , Ambepu Arundhathi , Krishnan Jithendranath , Kataria Raman , Afshar Salim , Meara John G , Galea Jerome T , Weinstock Peter , Roussin Christopher , Taylor Matthew , Menon Nandakumar , McClain Craig D 
Published: August 2020

Introduction
The benefits of simulation-based medical training are well described. The
most effective way to plant and scale simulation training in rural locations
remains undescribed. We sought to plant simulation training programmes for
anaesthesia emergencies in two rural Indian hospitals.

Methods
Two Indian consultant anaesthetists without experience in medical
simulation underwent a 3-day course at the Boston Children’s Hospital’s (BCH)
Simulator Program. They returned to their institutions and launched simulation
programmes with an airway manikin and mock patient monitor. The 1-year
experience was evaluated using individual, in-depth interviews of simulation
facilitators. Three staff members (responsible for facilitating medical
simulations over the prior year) at two rural hospitals in India were
interviewed. None attended the BCH training; instead, they received on-the-job
training from the BCH-trained, consultant anaesthetist colleagues.

Results
Successes included organisational adoption of simulation training with
exercises 1 year after the initial BCH-training, increased interdisciplinary
teamwork and improved clinical competency in managing emergencies. Barriers to
effective, local implementation of simulation programmes fell into three
categories: time required to run simulations, fixed and rigid roles, and
variable resources. Thematic improvement requests were for standardised
resources to help train simulation facilitators and demonstrate to participants
a well-run simulation, in addition to context-sensitive scenarios.

Conclusion
An in-person training of simulation facilitators to promote medical
simulation programmes in rural hospitals produced ongoing simulation programmes
1 year later. In order to make these programmes sustainable, however, increased
investment in developing simulation facilitators is required. In particular,
simulation facilitators must be prepared to formally train other simulation
facilitators, too.
Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer
Authors: Lu Zhihao , Chen Huan , Li Shuang , Gong Jifang , Li Jian , Zou Jianling , Wu Lihong , Yu Jianing , Han Wenbo , Sun Huaibo , Jiao Xi , Zhang Xiaotian , Peng Zhi , Lu Ming , Wang Zhenghang , Zhang Henghui , Shen Lin 
Published: August 2020

BackgroundDespite the great achievements made in immune-checkpoint-blockade (ICB) in cancer therapy, there are no effective predictive biomarkers in gastrointestinal (GI) cancer.MethodsThis study included 93 metastatic GI patients treated with ICBs. The first cohort comprising 73 GI cancer patients were randomly assigned into discovery (n=44) and validation (n=29) cohorts. Comprehensive genomic profiling was performed on all samples to determine tumor mutational burden (TMB) and copy-number alterations (CNAs). A subset of samples was collected for RNA immune oncology (IO) panel sequencing, microsatellite instability (MSI)/mismatch repair and program death ligand 1 (PD-L1) expression evaluation. In addition, 20 gastric cancer (GC) patients were recruited as the second validation cohort.ResultsIn the first cohort of 73 GI cancer patients, a lower burden of CNA was observed in patients with durable clinical benefit (DCB). In both the discovery (n=44) and validation (n=29) subsets, lower burden of CNA was associated with an improved clinical benefit and better overall survival (OS). Efficacy also correlated with a higher TMB. Of note, a combinatorial biomarker of TMB and CNA may better stratify DCB patients from ICB treatment, which was further confirmed in the second validation cohort of 20 GC patients. Finally, patients with lower burden of CNA revealed increased immune signatures in our cohort and The Cancer Genome Atlas data sets as well.ConclusionsOur results suggest that the burden of CNA may have superior predictive value compared with other signatures, including PD-L1, MSI and TMB. The joint biomarker of CNA burden and TMB may better stratify DCB patients, thereby providing a rational choice for GI patients treated with ICBs.
Safety and efficacy of CAR-T cell targeting BCMA in patients with multiple myeloma coinfected with chronic hepatitis B virus
Authors: Han Lu , Zhou Jian , Zhou Keshu , Zhu Xinghu , Zhao Lingdi , Fang Baijun , Yin Qingsong , Wei Xudong , Zhou Hu , Li Linlin , Xu Bengling , Zhang Jishuai , Song Yongping , Gao Quanli 
Published: August 2020

BackgroundReactivation of hepatitis B virus (HBV) infection is a well-recognized complication in patients with chronic or resolved HBV infection undergoing anticancer therapy. There is a risk of HBV reactivation after infusion of chimeric antigen receptor (CAR) T cells for patients with refractory/relapsed (R/R) multiple myeloma (MM).MethodsWe administered B cell maturation antigen (BCMA) CAR-T cell by infusion to nine patients with R/R MM with chronic or resolved HBV infection. Patient serum was analyzed to determine the expression of five components of HBV and the copy number of HBV DNA. HBV reactivation was defined if a patient re-exhibited hepatitis B surface antigen (HBsAg) or HBV DNA regrowth after CAR-T therapy.ResultsIn one patient who was HBsAg-positive, no HBV reactivation was observed during the follow-up period of 9.8 months after administration of anti-HBV drugs before and after CAR-T therapy. Among eight patients with MM who had resolved HBV infection, two patients administered prophylactic anti-HBV drugs did not exhibit HBV reactivation. Of the six patients who did not use prophylactic antiviral drugs, five did not exhibit HBV reactivation, while one showed recurrence of HBsAg without detection of HBV DNA or damage to liver function. The best objective response rate was 100%, and the progression-free survival (PFS) at 12 months was of 88.89% (median PFS was not observed).ConclusionsThese findings showed that BCMA CAR-T cell therapy could be used in patients with R/R MM with chronic or resolved HBV infection and that antiviral drugs should be administered in these patients during CAR-T cell therapy.
Revisiting the scalar weak gravity conjecture
Authors: Benakli Karim , Branchina Carlo , Lafforgue-Marmet Gaëtan 
Published: August 2020

AbstractWe revisit the scalar weak gravity conjecture and investigate the possibility to impose that scalar interactions dominate over gravitational ones. More precisely, we look for consequences of assuming that, for leading scalar interactions, the corresponding gravitational contribution is sub-dominant in the non-relativistic limit. For a single massive scalar particle, this leads us to compare four-point self-interactions in different type of potentials. For axion-like particles, we retrieve the result of the axion weak gravity conjecture: the decay constant f is bounded by the Planck mass, $$f < {M_{Pl}}$$f<MPl. Similar bounds are obtained for exponential potentials. For quartic, power law and Starobinsky potentials, we exclude large trans-Planckian field excursions. We then discuss the case of moduli that determine the scalars masses. We retrieve the exponential dependence as requested by the Swampland distance conjecture. We also find extremal state masses with field dependence that reproduces both the Kaluza-Klein and winding modes behaviour. In particular cases, our constraints can be put in the form of the Refined de Sitter Conjecture.