bluuebunny/crossref_metadata_2025_split huggingface dataset:
Judicial Review of Prosecutorial Discretion in the Initiation of Investigations into Situations of ‘Sufficient Gravity’
Authors: Urs Priya 
Published: May 2020

Abstract
In the admissibility framework of the Rome Statute, the Prosecutor’s discretion as to whether to initiate an investigation into a situation includes the application of the open-textured requirement of ‘sufficient gravity’ specified in Article 17(1)(d). Pre-Trial Chamber oversight is designed to discipline the exercise of this discretion, but, in the absence of statutory guidance, the Pre-Trial Chambers are left themselves to articulate the standards of review of the Prosecutor’s admissibility assessments under relevant provisions, namely Articles 53(3)(a) and 15(4) of the Statute. The confused body of Pre-Trial Chamber practice to date poses the question as to what ought to be the standard of review of the Prosecutor’s admissibility assessment under each provision. This article teases apart and scrutinizes the standards of review that the Pre-Trial Chambers have applied in practice. By disaggregating the procedural contexts in which the Prosecutor’s admissibility assessments are made and analysing in each context the underlying interests at stake, it seeks to arrive at the appropriate standard of judicial review of the Prosecutor’s gravity assessment under each provision.
Predicting the distribution of a rare chipmunk (Neotamias quadrivittatus oscuraensis): comparing MaxEnt and occupancy models
Authors: Perkins-Taylor Ian E , Frey Jennifer K 
Published: May 2020

Abstract
Species distribution models (SDMs) use presence records to determine the relationship between species occurrence and various environmental variables to create predictive maps describing the species’ distribution. The Oscura Mountains Colorado chipmunk (Neotamias quadrivittatus oscuraensis) occurs in central New Mexico and is of conservation concern due to its relict distribution and threats to habitat. We previously created an occupancy model for this taxon, but were concerned that the model may not have adequately captured the ecological factors influencing the chipmunk’s distribution because of the data hungry nature of occupancy modeling. MaxEnt is another SDM method that is particularly effective at testing large numbers of variables and handling small sample sizes. Our goal was to create a MaxEnt model for the Oscura Mountains Colorado chipmunk and to compare it with our previous occupancy model for this taxon, either to strengthen our original assessment of the relevant ecological factors or identify additional factors that were not captured by our occupancy model. We created MaxEnt models using occurrence records from baited camera traps and opportunistic surveys. We adjusted model complexity using a novel method for tuning both the regularization multiplier and feature class parameters while also performing variable selection. We compared the distribution maps and variables selected by MaxEnt to the results of our occupancy model for this taxon. The MaxEnt and occupancy models selected similar environmental variables and the overall spatial pattern of occurrence was similar for each model. Likelihood of occurrence was positively related to elevation, piñon woodland vegetation type, and topographic variables associated with escarpments. The overall similarities between the MaxEnt and occupancy models increased our confidence of the ecological factors influencing the distribution of the chipmunk. We conclude that MaxEnt offers advantages for predicting the distribution of rare species, which can help inform conservation actions.
TEOSINTE BRANCHED1 regulates height and stem internode length in bread wheat
Authors: Dixon Laura E , Pasquariello Marianna , Boden Scott A 
Published: May 2020

Abstract
Regulation of plant height and stem elongation has contributed significantly to improvement of cereal productivity by reducing lodging and improving distribution of assimilates to the inflorescence and grain. In wheat, genetic control of height has been largely contributed by the Reduced height-1 alleles that confer gibberellin insensitivity; the beneficial effects of these alleles are associated with less favourable effects involving seedling emergence, grain quality, and inflorescence architecture that have driven new research investigating genetic variation of stem growth. Here, we show that TEOSINTE BRANCHED1 (TB1) regulates height of wheat, with TB1 being expressed at low levels in nodes of the main culm prior to elongation, and increased dosage of TB1 restricting elongation of stem internodes. The effect of TB1 on stem growth is not accompanied by poor seedling emergence, as transgenic lines with increased activity of TB1 form longer coleoptiles than null transgenic controls. Analysis of height in a multiparent mapping population also showed that allelic variation for TB1 on the B genome influences height, with plants containing the variant TB-B1b allele being taller than those with the wild-type TB-B1a allele. Our results show that TB1 restricts height and stem elongation in wheat, suggesting that variant alleles that alter the expression or function of TB1 could be used as a new source of genetic diversity for optimizing architecture of wheat in breeding programmes.
Cross-correlating 21 cm and galaxy surveys: implications for cosmology and astrophysics
Authors: Padmanabhan Hamsa , Refregier Alexandre , Amara Adam 
Published: May 2020

ABSTRACT
We forecast astrophysical and cosmological parameter constraints from synergies between 21 cm intensity mapping and wide-field optical galaxy surveys (both spectroscopic and photometric) over z ∼ 0–3. We focus on the following survey combinations in this work: (i) a CHIME-like and DESI-like survey in the Northern hemisphere, (ii) an LSST-like and SKA I MID-like survey, and (iii) a MeerKAT-like and DES-like survey in the Southern hemisphere. We work with the ΛCDM cosmological model having parameters {h, Ωm, ns, Ωb, σ8}, parameters vc, 0 and β representing the cut-off and slope of the H i–halo mass relation in the previously developed H i halo model framework, and a parameter Q that represents the scale dependence of the optical galaxy bias. Using a Fisher forecasting framework, we explore (i) the effects of the H i and galaxy astrophysical uncertainties on the cosmological parameter constraints, assuming priors from the present knowledge of the astrophysics, (ii) the improvements on astrophysical constraints over their current priors in the three configurations considered, and (iii) the tightening of the constraints on the parameters relative to the corresponding H i autocorrelation surveys alone.
Abundance matching tested on small scales with galaxy dynamics
Authors: Macciò Andrea V , Courteau Stéphane , Ouellette Nathalie N-Q , Dutton Aaron A 
Published: May 2020

Abstract
We present a comprehensive test of the relation between stellar and total masses in galaxies as predicted by popular models based on abundance matching (AM) techniques. We use the ‘Spectroscopy and H-band Imaging of Virgo cluster galaxies’ (SHIVir) survey with photometric and dynamical profiles for 190 Virgo cluster galaxies to establish a relation between the stellar and dynamical masses measured within the isophotal radius r23.5. Various dark matter and galaxy scaling relations are combined with results from the NIHAO (Numerical Investigation of Hundred Astrophysical Objects) suite of hydrodynamical simulations to recast AM predictions in terms of these observed quantities. Our results are quite insensitive to the exact choice of dark matter profile and halo response to baryon collapse. We find that theoretical models reproduce the slope and normalization of the observed stellar-to-halo mass relation (SHMR) over more than three orders of magnitude in stellar mass (108 &lt; M*/M⊙ &lt; 2 × 1011). However, the scatter of the observed SHMR exceeds that of AM predictions by a factor of ∼5. For systems with stellar masses exceeding 5 × 1010 M⊙, AM overpredicts the observed stellar masses for a given dynamical mass. The latter offset may support previous indications of a different stellar initial mass function in these massive galaxies. Overall, our results support the validity of AM predictions on a wide dynamical range.
The Neandertal Progesterone Receptor
Authors: Zeberg Hugo , Kelso Janet , Pääbo Svante 
Published: May 2020

Abstract
The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element. These Neandertal gene variants have reached nearly 20% frequency in non-Africans and have been associated with preterm birth. Here, we show that one of the missense substitutions appears fixed in Neandertals, while the other substitution as well as the Alu insertion were polymorphic among Neandertals. We show that two Neandertal haplotypes carrying the PGR gene entered the modern human population and that present-day carriers of the Neandertal haplotypes express higher levels of the receptor. In a cohort of present-day Britons, these carriers have more siblings, fewer miscarriages, and less bleeding during early pregnancy suggesting that the Neandertal progesterone receptor alleles promote fertility. This may explain their high frequency in modern human populations.
Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
Authors: Grau-Bové Xavier , Tomlinson Sean , O’Reilly Andrias O , Harding Nicholas J , Miles Alistair , Kwiatkowski Dominic , Donnelly Martin J , Weetman David ,   and The Anopheles gambiae 1000 Genomes Consortium
Published: May 2020

AbstractThe evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across nonconcordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.
推进全谷物消费的全球策略
Authors: Toups Kelly E 
Published: May 2020

Abstract
全谷物是健康饮食的重要组成部分已是全球普遍的共识；然而，许多国家居民全谷物摄入量一直尚未达到推荐摄入量。本文目的是评 估拥有不同饮食文化的4 个国家在推进全谷物消费所采取的策略与方 法，即美国、新加坡、菲律宾和丹麦。为此，收集了每个目标国家与 全谷物相关的法规、非政府组织(NGO)举办的活动和推广项目等信 息。这项努力旨在总结出在公共和个人领域促进全谷物消费的最佳实 践方法。
Factors associated with unsuccessful return-to-work following work-related upper extremity injury
Authors: von Schroeder H P , Xue C (R) , Yak A , Gandhi R 
Published: May 2020

Abstract

Background
Returning to work following occupational injury is a key outcome for both workers’ compensation boards and injured workers. Predictive factors for returning remain unclear.

Aims
To describe factors associated with unsuccessful return-to-work (RTW) in a hand injury population to identify target areas through which occupational rehabilitation programmes can help injured workers achieve successful RTW outcomes.

Methods
Demographic data, functional, pain and psychosocial scores were recorded for injured workers discharged between April 2011 and September 2015 from a multidisciplinary upper extremity treatment programme. The primary outcome of RTW status was assessed at programme discharge. Bivariate analyses and multivariable logistic regression were used to identify factors associated with being unable to RTW.

Results
Of 872 participants who met the inclusion criteria, 65% were male and the mean age was 46 (standard deviation [SD] 11) years. In unadjusted bivariate analyses, the group with an unsuccessful RTW outcome had higher mean baseline pain, catastrophizing and QuickDASH scores; a higher baseline prevalence of depression, and reported a high level of pain more frequently than those who were working at discharge. In the adjusted logistic regression model, not working at baseline, higher QuickDASH score and presence of depression at baseline were independently associated with unsuccessful work status outcome.

Conclusions
Negative baseline work status, greater self-reported functional disability and presence of depression were associated with greater odds of unsuccessful RTW following a workplace upper extremity injury. Integrating mental healthcare provision with occupational rehabilitation is a potential programmatic approach to improve RTW.
Doctor of Physical Therapy Education in a Hybrid Learning Environment: Reimagining the Possibilities and Navigating a “New Normal”
Authors: Gagnon Kendra , Young Brian , Bachman Teresa , Longbottom Thomas , Severin Richard , Walker Michael J 
Published: May 2020

Abstract
Professional physical therapist education has experienced a transformation over the last few decades, moving to a doctoring profession with more autonomy and a broader scope of practice. These changes have occurred in parallel with systemic and structural changes in health care and higher education, both of which have experienced challenges with improving access and controlling costs, and have become a centerpiece of legislative and political discourse. At the same time, advances in technology have introduced new possibilities in education, with the emergence of online, blended, and “flipped” learning models that supplement or replace face-to-face instruction with distance learning. Hybrid education is a type of blended learning, utilizing both face-to-face and online instructional strategies. In a hybrid learning environment, online content may be delivered synchronously or asynchronously, replacing traditional face-to-face instructional time and reducing “seat time” for students. Recent attention has been brought to online and hybrid/blended learning in physical therapist education in the wake of the COVID-19 pandemic, as programs have been required to abruptly move from face-to-face to remote instruction. Hybrid and other forms of blended learning strategies have been described at the physical therapist education course level. However, there is no literature describing hybrid learning implementation at the physical therapist education program “levels,” and there has been limited discussion on best practices for delivering hybrid, blended, and online instruction in physical therapist education. This perspective provides an overview of hybrid education, describes theoretical frameworks that guide implementation of a hybrid education curriculum, and discusses future directions for hybrid physical therapist education and educational research.
Juvenile Paget’s disease: Report of a family with a novel missense mutation and unique radiological manifestations in a heterozygote
Authors: Khalifa O , Ramzan K , Moustafa A S , AlMane K , Abdelfattah M , Abuharb G , Hegde M , Alsayed M 
Published: May 2020

Abstract

Juvenile Paget’s disease (JPD) is a rare, generalized skeletal disorder characterized by markedly increased bone turnover secondary to enhanced osteoclastic activity. The patients with JPD develop progressive, widespread skeletal involvement and non-skeletal manifestations.

Objectives
To identify the characteristic molecular, biochemical, radiological, and audiological findings in three siblings with JPD associated with intrafamilial phenotypic variability.

Patients and Methods
A Saudi family with 3 affected siblings was recruited. Biochemical measurement of serum alkaline phosphatase and markers of bone turnover were performed. Genetic testing and sequencing of a panel of 22 known genes for skeletal dysplasia with increase bone density were performed by next generation sequencing (NGS). Radiological and audiological assessment were also performed.

Results
Patients showed marked elevation of serum alkaline phosphatase and markers of bone turnover. A novel homozygous mutation c.433T&gt;G (p.Cys145Gly) in exon 3 of TNFRSF11B gene was identified in the 3 affected siblings. Both parents were heterozygous for the mutation. The heterozygote father had thickening of calvarium, a radiological manifestation of JPD. The eldest child (index case) had a unique striking distortion of the skull bones as evidenced by 3-D computed tomography of skull. He had also bilateral inner ear structural deformity and severe sensorineural hearing loss.
Conclusions: JPD is a rare disorder that can be highly overlooked due to phenotypic overlap with other disorders of skeletal dysplasia. Mutations affecting cysteine residues result in the most severe JPD phenotypes. NGS is useful for early diagnosis of JPD, a prerequisite for successful treatment strategy.
Role of PET/CT in Assessment of Recurrent Ovarian Tumors
Authors: Kadry S , Haggag A , Ekbal A 
Published: May 2020

Abstract

Background
Ovarian cancer remains a major health problem worldwide, with over 225,000 new cases and 140,000 deaths reported annually. Despite high response after initial treatment, 20-30% of patients with early-stage disease and up to 75% of patients with advanced disease present with recurrence within two years. Early diagnosis of recurrence is crucial for determination of the best treatment.

Aim of the Work
is to detect the significance of PET/CT in the early detection of recurrent ovarian tumors.

Patients and Method
The study included 25 patients who have been diagnosed with ovarian cancer, received treatment and achieved complete response. All of the 25 patients had suspected recurrence either due to elevated tumor markers or suspicious clinical findings. The 25 patients have been referred for PET/CT scan at ElDemerdash university hospital from July 2017 to August 2018.

Results
Total of 25 patients were included in the study. 18 of 25 patients had high tumor marker (CA 125) level. The remaining 7 patients had suspected recurrence with normal tumor marker levels. Recurrence was confirmed by histopathology or clinical and imaging follow up in 19 patients of the 25 patients. Recurrent disease was not shown in 5 of 19 patients on CECT imaging and 1 of 19 patients on PET/CT imaging. PET/CT had a sensitivity of (94.74%), specificity of (100%) and accuracy of (96%). CECT has been reported with sensitivity of (73.68), specificity of (83.33%) and accuracy of (76%).

Conclusion
PET/CT is a useful tool and has a higher sensitivity, specificity and accuracy than CECT in detection of recurrent ovarian cancer.
Ultrasound Elastography and TI- Rads (Thyroid Imaging Reporting and Data System) in the Diagnostic Evaluation of Thyroid Nodules
Authors: Ali M A , Abdelrahman A S , Khalaf A M 
Published: May 2020

Abstract

Background
Thyroid nodules refers to an abnormal growth of thyroid cells that forms a lump within the thyroid gland. Although the vast majority of thyroid nodules are benign , a small percent is presenting as a thyroid cancer.

Objective
To quantify the sensitivity & the specifity of ultrasound elastography and TI-RAADS in evaluation of thyroid nodules among study population in Ain Shams university hospitals.

Patients and Methods
Type of study: cross sectional study. Study setting: it was conducted at Ain Shams University hospitals. Study period: March2018 to September 2018. Sample size: 41 patients were included in this study.

Results
There is a significant increase in the hyperechoic and isoechoic echogenicity in benign groups while no significant difference in hypoechogenicity and a significant difference in very hypoechogenicity in malignant group P- value=0.002.

Conclusion
Finally both the use of TI- RADS and elastography are methods to evaluate thyroids nodules according to US features and scoring systems that they are easy to perform, not invasive, informative, not costy and can be combined together to increase the accuracy of evaluation.
Value of transcranial ultrasound screening for the preterm in the neonatal ICU
Authors: Ali S B , Abdelrahman A S , Hassan M I 
Published: May 2020

Abstract

Background
preterm neonates less than 37 weeks of gestational age are more liable to hemorrhagic and ischemic brain lesions due to the immaturity of capillary bed, cerebral auto-regulation and vascular anastomosis, with consequent adverse outcome, poor cognitive development, and cerebral palsy. Cranial ultrasound is a safe imaging modality with no need to radiation exposure or sedation.

Aim of the Work
to evaluate the usefulness of universal cranial ultrasound screening in preterm neonates in the neonatal ICU with gestational age between 28 and 37 weeks to detect the different intra cranial pathologies in this pediatric group.

Patients and Methods
After taking approval by the Radiology Department Committee of the Faculty of Medicine, Ain shams University, the current study was performed on all preterm neonates (50) admitted to neonatal ICU in Ain shams hospital between 28 and 37 weeks of gestational age, between the third and seventh day of life, from July 1, 2017 to April 1, 2018 were included in the study.

Results
The study showed normal transcrainal ultrasound (72.0%), Germinal matrix hemorrhage (10.0%), Intraventricular hemorrhage (6.0%), Periventricular leukomalacia (6.0%), Congenital anomalies is Dandy walker malformation (2.0%), Chiari malformation (0.0%), Agenesis of corpus callosum (2.0%) and Porencephalic cyst (2.0%) of finding of ultrasound.

Conclusion
The importance of preterm screening by cranial ultrasound is sustained by the observation that most preterm neonates with abnormal CUS are usually asymptomatic. Only occasionally these patients develop symptoms.Linear high frequency probe of ultrasound was of great benefit in better visualization of anatomical details and mild pathological lesions.