bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights on congenital pulmonary airways malformations revealed by proteomic analyses
Authors: Barazzone-Argiroffo C. , Lascano Maillard J. , Vidal I. , Bochaton-Piallat M. L. , Blaskovic S. , Donati Y. , Wildhaber B. E. , Rougemont A.-L. , Delacourt C. , Ruchonnet-Métrailler I. 
Published: November 2019

AbstractBackgroundCongenital Pulmonary Airway Malformation (CPAM) has an estimated prevalence between 0.87 and 1.02/10,000 live births and little is know about their pathogenesis. To improve our knowledge on these rare malformations, we analyzed the cellular origin of the two most frequent CPAM, CPAM types 1 and 2, and compared these malformations with adjacent healthy lung and human fetal lungs.MethodsWe prospectively enrolled 21 infants undergoing surgical resection for CPAM. Human fetal lung samples were collected after termination of pregnancy. Immunohistochemistry and proteomic analysis were performed on laser microdissected samples.ResultsCPAM 1 and 2 express mostly bronchial markers, such as cytokeratin 17 (Krt17) or α-smooth muscle actin (ACTA 2). CPAM 1 also expresses alveolar type II epithelial cell markers (SPC). Proteomic analysis on microlaser dissected epithelium confirmed these results and showed distinct protein profiles, CPAM 1 being more heterogeneous and displaying some similarities with fetal bronchi.ConclusionThis study provides new insights in CPAM etiology, showing clear distinction between CPAM types 1 and 2, by immunohistochemistry and proteomics. This suggests that CPAM 1 and CPAM 2 might occur at different stages of lung branching. Finally, the comparison between fetal lung structures and CPAMs shows clearly different protein profiles, thereby arguing against a developmental arrest in a localized part of the lung.
Real-time analysis of ATP concentration in acupoints during acupuncture: a new technique combining microdialysis with patch clamp
Authors: Wu Yong , Huang Meng , Xia Ying , Ding Guanghong 
Published: November 2019

AbstractThis paper introduces a new technique combining microdialysis with patch clamp to detect the changes in ATP (adenosine triphosphate) concentration in acupoints during acupuncture. The microdialysis probe was implanted into the Zusanli acupoint (ST 36) of adult SD (Sprague Dawley) rats to sample acupoint fluid containing ATP released during acupuncture. Then, the fluid with ATP was delivered in real time to 293 T cells overexpressing P2X3 receptors, with which we could carry out patch clamp experiments. The results showed that changes in membrane currents could reflect changes in the concentration of ATP. Thus, we can successfully detect ATP released in acupoints during acupuncture in real time. This technique provides us with a new way to study the mechanism of acupuncture signal initiation.
TRIal to slow the Progression Of Diabetes (TRIPOD): study protocol for a randomized controlled trial using wireless technology and incentives
Authors: Lim Robyn Su May , Gardner Daphne Su Lyn , Bee Yong Mong , Cheung Yin Bun , Bairavi Joann , Gandhi Mihir , Goh Su-Yen , Ho Emily Tse Lin , Lin Xinyi , Tan Ngiap Chuan , Tay Tunn Lin , Finkelstein Eric Andrew 
Published: November 2019

Abstract
Background
The outcomes for those with type 2 diabetes mellitus (T2DM) in Singapore are poor. In this TRIal to slow the Progression Of Diabetes (TRIPOD), we will evaluate the effectiveness and cost-effectiveness of a comprehensive diabetes management package (DMP), with or without a financial incentives program, M-POWER Rewards, in efforts to improve HbA1c levels for individuals with T2DM.

Methods/design
TRIPOD is a randomized, open-label, controlled, multi-center, superiority trial with three parallel arms: (1) usual care only, (2) usual care with DMP, and (3) usual care with DMP plus M-POWER Rewards. A total of 339 adults with sub-optimally controlled T2DM (self-reported HbA1c 7.5–11.0%) will be block randomized according to a 1:1:1 allocation ratio to the three arms. The primary outcome is mean change in HbA1c level at Month 12 from baseline. Secondary outcomes include mean change in HbA1c level at Months 6, 18, and 24; mean changes at Months 6, 12, 18, and 24 in weight, blood pressure, and self-reported physical activity, weight monitoring, blood glucose monitoring, medication adherence, diabetes self-management, sleep quality, work productivity and daily activity impairment, and health utility index; and proportion of participants initiating insulin treatment by Months 6, 12, 18, and 24. Incremental cost-effectiveness ratios will be computed based on costs per improvement in HbA1c at Month 12 and converted to cost per quality-adjusted life year gained.

Discussion
The TRIPOD study will present insights about the long-term cost-effectiveness and financial viability of the interventions and the potential for integrating within usual care.

Trial registration
ClinicalTrials.gov, NCT03800680. Registered on 11 January 2019.
Examining the effectiveness of general practitioner and nurse promotion of electronic cigarettes versus standard care for smoking reduction and abstinence in hardcore smokers with smoking-related chronic disease: protocol for a randomised controlled trial
Authors: Begh Rachna , Coleman Tim , Yardley Lucy , Barnes Rebecca , Naughton Felix , Gilbert Hazel , Ferrey Anne , Madigan Claire , Williams Nicola , Hamilton Louisa , Warren Yolanda , Grabey Jenna , Clark Miranda , Dickinson Anne , Aveyard Paul 
Published: November 2019

Abstract
Background
Despite the clear harm associated with smoking tobacco, many people with smoking-related chronic diseases or serious mental illnesses (SMI) are unwilling or unable to stop smoking. In many cases, these smokers have tried and exhausted all methods to stop smoking and yet clinicians are repeatedly mandated to offer them during routine consultations. Providing nicotine through electronic cigarettes (e-cigarettes) may reduce the adverse health consequences associated with tobacco smoking, but these are not currently offered. The aim of this study is to examine the feasibility, acceptability and effectiveness of general practitioners (GPs) and nurses delivering a brief advice intervention on e-cigarettes and offering an e-cigarette starter pack and patient support resources compared with standard care in smokers with smoking-related chronic diseases or SMI who are unwilling to stop smoking.

Methods/design
This is an individually randomised, blinded, two-arm trial. Smokers with a smoking-related chronic condition or SMI with no intention of stopping smoking will be recruited through primary care registers. Eligible participants will be randomised to one of two groups if they decline standard care for stopping smoking: a control group who will receive no additional support beyond standard care; or an intervention group who will receive GP or nurse-led brief advice about e-cigarettes, an e-cigarette starter pack with accompanying practical support booklet, and telephone support from experienced vapers and online video tutorials. The primary outcome measures will be smoking reduction, measured through changes in cigarettes per day and 7-day point-prevalence abstinence at 2 months. Secondary outcomes include smoking reduction, 7-day point-prevalence abstinence and prolonged abstinence at 8 months. Other outcomes include patient recruitment and follow-up, patient uptake and use of e-cigarettes, nicotine intake, contamination of randomisation and practitioner adherence to the delivery of the intervention. Qualitative interviews will be conducted in a subsample of practitioners, patients and the vape team to garner their reactions to the programme.

Discussion
This is the first randomised controlled trial to investigate whether e-cigarette provision alongside a brief intervention delivered by practitioners leads to reduced smoking and abstinence among smokers with smoking-related chronic diseases or SMI.

Trial registration
ISRCTN registry, ISRCTN59404712. Registered 28/11/17.
An adaptive retransmit mechanism for delay differentiated services in industrial WSNs
Authors: Chen Ye , Liu Wei , Wang Tian , Deng Qingyong , Liu Anfeng , Song Houbing 
Published: November 2019

AbstractThe Internet of Things (IoT) is the latest Internet development, with billions of Internet-connected devices and a wide range of industrial applications. Wireless sensor networks are an important part of the Internet of Things. It has received extensive attention from researchers due to its large-scale, self-organizing, and dynamic characteristics and has been widely used in industry, traffic information, military, environmental monitoring, and so on. With the development of microprocessor technology, sensor nodes are becoming more and more powerful, which enables the same wireless sensor networks (WSNs) platform to meet the different quality of service (QoS) requirements of many applications. Applications for industrial wireless sensor networks range from lower physical layers to higher application layers. The same wireless sensor network sometimes needs to process information from different layers. Traditional protocols lack differentiated services and cannot make full use of network resources. In this paper, an Adaptive Retransmit Mechanism for Delay Differentiated Services (ARM-DDS) scheme is proposed to meet different levels of delays of applications. Firstly, we analyze the impact of different retransmit mechanisms and parameter optimization on delays and energy consumption. Based on the results of the analysis, in ARM-DDS scheme, for routes with transmission delay tolerance, energy-saving retransmission mechanisms are used, and low-latency retransmission mechanisms are used for latency-sensitive routes. In this way, the data routing delays of different applications are guaranteed within bound and the energy consumption of the network is reduced. What is more, ARM-DDS scheme makes full use of the residual energy of the network and uses a small delay routing retransmit mechanism in the far-sink area to reduce end-to-end delay. Both theoretical analysis and simulation experiments show that under the premise of the same reliability requirements, ARM-DDS scheme reduces data transmission delay 12.1% and improves network energy utilization 28%. Given that the reliability requirements of the data stream are different, the scheme can also extend the network lifetime.
Recruitment and retention of fathers with young children in early childhood health intervention research: a systematic review and meta-analysis protocol
Authors: Keys Elizabeth M. , Norris Jill M. , Cameron Emily E. , Bright Katherine S. , Tomfohr-Madsen Lianne M. , Benzies Karen M. 
Published: December 2019

AbstractBackgroundFathers are under-represented in research and programs addressing early childhood health and development. Recruiting fathers into these interventions can be hampered for multiple reasons, including recruitment and retention strategies that are not tailored for fathers. The primary aim of this systematic review and meta-analysis is to determine the effectiveness of recruitment and retention strategies used to include fathers of children (from conception to age 36 months) in intervention studies. The secondary aim is to investigate study-level factors that may influence recruitment and retention.MethodsWe will conduct searches for scholarly peer-reviewed randomized controlled trials, quasi-experimental studies, and pre-post studies that recruited fathers using the following databases: MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), and CINAHL. English-language articles will be eligible if they recruited self-identified fathers of children from conception to age 36 months for health-promoting interventions that target healthy parents and children. Two reviewers will independently screen titles/abstracts and full texts for inclusion, as well as grading methodological quality. Recruitment and retention proportions will be calculated for each study. Where possible, we will calculate pooled proportional effects with 95% confidence intervals using random-effects models and conduct a meta-regression to examine the impact of potential modifiers of recruitment and retention.DiscussionFindings from this review will help inform future intervention research with fathers to optimally recruit and retain participants. Identifying key factors should enable health researchers and program managers design and adapt interventions to increase the likelihood of increasing father engagement in early childhood health interventions. Researchers will be able to use this review to inform future research that addresses current evidence gaps for the recruitment and retention of fathers. This review will make recommendations for addressing key target areas to improve recruitment and retention of fathers in early childhood health research, ultimately leading to a body of evidence that captures the full potential of fathers for maximizing the health and wellbeing of their children.Systematic review registrationPROSPEROCRD42018081332.
On implicit impulsive Langevin equation involving mixed order derivatives
Authors: Zada Akbar , Rizwan Rizwan , Xu Jiafa , Fu Zhengqing 
Published: November 2019

AbstractIn this paper, we consider a nonlocal boundary value problem of nonlinear implicit impulsive Langevin equation involving mixed order derivatives. Sufficient conditions are constructed to discuss the qualitative properties like existence and Ulam’s stability of the proposed problem. The main result is verified by an example.
Low-level retention forestry, certification, and biodiversity: case Finland
Authors: Kuuluvainen Timo , Lindberg Henrik , Vanha-Majamaa Ilkka , Keto-Tokoi Petri , Punttila Pekka 
Published: December 2019

AbstractIn managed forests, leaving retention trees during final harvesting has globally become a common approach to reconciling the often conflicting goals of timber production and safeguarding biodiversity and delivery of several ecosystem services. In Finland, the dominant certification scheme requires leaving low levels of retention that can benefit some specific species. However, species responses are dependent on the level of retention and the current low amounts of retention clearly do not provide the habitat quality and continuity needed for declining and red-listed forest species which are dependent on old living trees and coarse woody debris. Several factors contribute to this situation. First, the ecological benefits of the current low retention levels are further diminished by monotonous standwise use of retention, resulting in low variability of retention habitat at the landscape scale. Second, the prevailing timber-oriented management thinking may regard retention trees as an external cost to be minimized, rather than as part of an integrated approach to managing the ecosystem for specific goals. Third, the main obstacles of development may still be institutional and policy-related. The development of retention practices in Finland indicates that the aim has not been to use ecological understanding to attain specific ecological sustainability goals, but rather to define the lowest level of retention that still allows access to the market. We conclude that prevailing retention practices in Finland currently lack ecological credibility in safeguarding biodiversity and they should urgently be developed based on current scientific knowledge to meet ecological sustainability goals.
Hand hygiene – social network analysis of peer-identified and management-selected change agents
Authors: Lee Yew Fong , McLaws Mary-Louise , Ong Loke Meng , Amir Husin Suraya , Chua Hock Hin , Wong See Yin , Pittet Didier , Zingg Walter 
Published: November 2019

Abstract
Background
Hand hygiene compliance can be improved by strategies fostering collaborative efforts among healthcare workers (HCWs) through change agents. However, there is limited information about how change agents shape the social networks of work teams, and how this relates to organisational culture. The objectives of this study were to describe the influence of peer-identified change agents (PICAs) and management-selected change agents (MSCAs) on hand hygiene, perception of their leadership style by peers, and the role of the organisational culture in the process of hand hygiene promotion.

Methods
This study, stratified in pre-, during, and post-intervention periods, was conducted between February 2017 and March 2018 in two wards at a tertiary care hospital in Malaysia. Hand hygiene promotion was facilitated either by PICAs (study arm 1) or MSCAs (study arm 2), and the two wards were randomly allocated to one of the two interventions. Outcomes were: 1) perceived leadership styles of PICAs and MSCAs by staff, vocalised during question and answer sessions; 2) the social network connectedness and communication patterns between HCWs and change agents by applying social network analysis; and 3) hand hygiene leadership attributes obtained from HCWs in the post-intervention period by questionnaires.

Results
Hand hygiene compliance in study arm 1 and study arm 2 improved by from 48% (95% CI: 44–53%) to 66% (63–69%), and from 50% (44–55%) to 65% (60–69%), respectively. There was no significant difference between the two arms. Healthcare workers perceived that PICAs lead by example, while MSCAs applied an authoritarian top-down leadership style. The organisational culture of both wards was hierarchical, with little social interaction, but strong team cohesion. Position and networks of both PICAs and MSCAs were similar and generally weaker compared to the leaders who were nominated by HCWs in the post-intervention period. Healthcare workers on both wards perceived authoritative leadership to be the most desirable attribute for hand hygiene improvement.

Conclusion
Despite experiencing successful hand hygiene improvement from PICAs, HCWs expressed a preference for the existing top-down leadership structure. This highlights the limits of applying leadership models that are not supported by the local organisational culture.
Complete atrioventricular block due to timolol eye drops: a case report and literature review
Authors: Wang Zhuoying , Denys Ian , Chen Feng , Cai Lijie , Wang Xuecui , Kapusta Daniel R. , Lv Yongliang , Gao Juan 
Published: December 2019

Abstract
Background
Timolol Maleate is a non-selective beta-adrenergic blocker that is commonly used to treat open-angle glaucoma. Despite its topical administration, ophthalmic timolol enters systemic circulation and produces a systemic beta-adrenergic blockade. We report a case of long-term timolol use that uncovered and worsened an underlying cardiac conduction defect demonstrated as a third degree atrioventricular (AV) block.

Case presentation
A 62-year old male with a 13-year history of glaucoma was hospitalized due to shortness of breath, dizziness, and amaurosis. Electrocardiography indicated a heart rate (HR) of 29 bpm with complete atrioventricular (AV) block, and the HR was significantly increased with the treatment of isoprenaline. However, the patient experienced bradycardic episodes (− 20 Δbpm) immediately after self-administration of timolol eye drops. The AV block and bradycardia resolved 48-h after timolol cessation. The man was discharged 1 week later with an asymptomatic first-degree A-V block. However, he presented with a worsened A-V block at his one-year checkup.

Conclusion
We conclude that chronic topical timolol administration may aggravate a cardiac conduction defect leading to an AV block that is only temporarily resolved by timolol cessation. Patients taking timolol should be routinely monitored for cardiovascular aberrations and if any detected, immediately discontinue timolol therapy. Individuals experiencing timolol induced cardiovascular side effects should receive long term follow-up even if symptoms resolve, as they may be indicative of an underlying conduction defect.
Borderline personality disorder diagnosis in a new key
Authors: Mulay Abby L. , Waugh Mark H. , Fillauer J. Parks , Bender Donna S. , Bram Anthony , Cain Nicole M. , Caligor Eve , Forbes Miriam K. , Goodrich Laurel B. , Kamphuis Jan H. , Keeley Jared W. , Krueger Robert F. , Kurtz John E. , Jacobsson Peter , Lewis Katie C. , Rossi Gina M. P. , Ridenour Jeremy M. , Roche Michael , Sellbom Martin , Sharp Carla , Skodol Andrew E. 
Published: December 2019

Abstract
Background
Conceptualizations of personality disorders (PD) are increasingly moving towards dimensional approaches. The definition and assessment of borderline personality disorder (BPD) in regard to changes in nosology are of great importance to theory and practice as well as consumers. We studied empirical connections between the traditional DSM-5 diagnostic criteria for BPD and Criteria A and B of the Alternative Model for Personality Disorders (AMPD).

Method
Raters of varied professional backgrounds possessing substantial knowledge of PDs (N = 20) characterized BPD criteria with the four domains of the Level of Personality Functioning Scale (LPFS) and 25 pathological personality trait facets. Mean AMPD values of each BPD criterion were used to support a nosological cross-walk of the individual BPD criteria and study various combinations of BPD criteria in their AMPD translation. The grand mean AMPD profile generated from the experts was compared to published BPD prototypes that used AMPD trait ratings and the DSM-5-III hybrid categorical-dimensional algorithm for BPD. Divergent comparisons with DSM-5-III algorithms for other PDs and other published PD prototypes were also examined.

Results
Inter-rater reliability analyses showed generally robust agreement. The AMPD profile for BPD criteria rated by individual BPD criteria was not isomorphic with whole-person ratings of BPD, although they were highly correlated. Various AMPD profiles for BPD were generated from theoretically relevant but differing configurations of BPD criteria. These AMPD profiles were highly correlated and showed meaningful divergence from non-BPD DSM-5-III algorithms and other PD prototypes.

Conclusions
Results show that traditional DSM BPD diagnosis reflects a common core of PD severity, largely composed of LPFS and the pathological traits of anxiousness, depressively, emotional lability, and impulsivity. Results confirm the traditional DSM criterion-based BPD diagnosis can be reliably cross-walked with the full AMPD scheme, and both approaches share substantial construct overlap. This relative equivalence suggests the vast clinical and research literatures associated with BPD may be brought forward with DSM-5-III diagnosis of BPD.