bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoskeleton—a crucial key in host cell for coronavirus infection
Authors: Wen Zeyu , Zhang Yue , Lin Zhekai , Shi Kun , Jiu Yaming 
Published: July 2020

AbstractThe emerging coronavirus (CoV) pandemic is threatening the public health all over the world. Cytoskeleton is an intricate network involved in controlling cell shape, cargo transport, signal transduction, and cell division. Infection biology studies have illuminated essential roles for cytoskeleton in mediating the outcome of host‒virus interactions. In this review, we discuss the dynamic interactions between actin filaments, microtubules, intermediate filaments, and CoVs. In one round of viral life cycle, CoVs surf along filopodia on the host membrane to the entry sites, utilize specific intermediate filament protein as co-receptor to enter target cells, hijack microtubules for transportation to replication and assembly sites, and promote actin filaments polymerization to provide forces for egress. During CoV infection, disruption of host cytoskeleton homeostasis and modification state is tightly connected to pathological processes, such as defective cytokinesis, demyelinating, cilia loss, and neuron necrosis. There are increasing mechanistic studies on cytoskeleton upon CoV infection, such as viral protein‒cytoskeleton interaction, changes in the expression and post-translation modification, related signaling pathways, and incorporation with other host factors. Collectively, these insights provide new concepts for fundamental virology and the control of CoV infection.
Lucky Me: The Amiable and Weighty Influences on My Career
Authors: Beauchamp Tom L 
Published: July 2020

Abstract
This autobiographical sketch is being published 50 years after I started as an assistant professor at Georgetown University in 1970. In this presentation, I cannot tell the full story of these 50 years. I write only about the formative years both before and after I was hired at Georgetown, and I emphasize two subjects. The first is the importance of the individuals who were massive influences on my intellectual development and aspirations. The second is the great importance of multidisciplinary work. I came from philosophy, a discipline that generally did not emphasize or particularly value multidisciplinary work, but I was transformed by individuals in other disciplines who directed me to this style of work. Almost sheer luck brought each of these influences into my life.
Common Susceptibility Loci for Male Breast Cancer
Authors: Maguire Sarah , Perraki Eleni , Tomczyk Katarzyna , Jones Michael E , Fletcher Olivia , Pugh Matthew , Winter Timothy , Thompson Kyle , Cooke Rosie ,   kConFab Consortium, Trainer Alison , James Paul , Bojesen Stig , Flyger Henrik , Nevanlinna Heli , Mattson Johanna , Friedman Eitan , Laitman Yael , Palli Domenico , Masala Giovanna , Zanna Ines , Ottini Laura , Silvestri Valentina , Hollestelle Antoinette , Hooning Maartje J , Novaković Srdjan , Krajc Mateja , Gago-Dominguez Manuela , Castelao Jose Esteban , Olsson Hakan , Hedenfalk Ingrid , Saloustros Emmanouil , Georgoulias Vasilios , Easton Douglas F , Pharoah Paul , Dunning Alison M , Bishop D Timothy , Neuhausen Susan L , Steele Linda , Ashworth Alan , Garcia Closas Montserrat , Houlston Richard , Swerdlow Anthony , Orr Nick 
Published: July 2020

Abstract

Background
The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC.

Methods
We performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 controls was used to validate variants with P values less than 1 × 10–06. Genetic correlation with FBC was evaluated using linkage disequilibrium score regression, by comprehensively examining the associations of published FBC risk loci with risk of MBC and by assessing associations between a FBC polygenic risk score and MBC. All statistical tests were 2-sided.

Results
The genome-wide association study identified 3 novel MBC susceptibility loci that attained genome-wide statistical significance (P &lt; 5 × 10–08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen receptor–positive FBC. Men in the top quintile of genetic risk had a fourfold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 × 10–30).

Conclusions
These findings advance our understanding of the genetic basis of MBC, providing support for an overlapping genetic etiology with FBC and identifying a fourfold high-risk group of susceptible men.
Taking us to the Vulnerability Scene: Television News Coverage and Framing of Internally Displaced Persons in Nigeria
Authors: Apuke Oberiri Destiny , Tunca Elif Asude 
Published: July 2020

Abstract
Despite the growing interest in the internally displaced person's (IDPs) media coverage in developing countries, studies on visual coverage are still in their embryonic stages. In this view, we examined Television news coverage of IDPs in Nigeria. We studied two broadcasting channels; Channels TV and the Nigeria Television Authority (NTA) from October 2018 to October 2019. We also interviewed some journalists and editors who reported and edited stories on IDPs. We anchored our study on the framing theory. Results showed that the two media outlets covered (n = 102) stories of IDPs. However, the private media (Channels TV) paid more attention to IDPs. Also, the private press placed more IDPs stories on its headline and most of which appeared in the first two headlines. Additional findings showed a significant difference in the visual frames; the private media used more visual and motion footages. Results from the interviews suggest that media ownership and control, media sources, advertisers, lack of adequate training, insufficient remuneration/incentive, and competition/ deadline syndrome influence media framing and coverage of IDPs in Nigeria. We concluded with some theoretical and practical implications.
External α-carbonic anhydrase and solute carrier 4 are required for bicarbonate uptake in a freshwater angiosperm
Authors: Huang Wenmin , Han Shijuan , Jiang Hongsheng , Gu Shuping , Li Wei , Gontero Brigitte , Maberly Stephen C 
Published: July 2020

AbstractThe freshwater monocot Ottelia alismoides is the only known species to operate three CO2-concentrating mechanisms (CCMs): constitutive bicarbonate (HCO3–) use, C4 photosynthesis, and facultative Crassulacean acid metabolism, but the mechanism of HCO3– use is unknown. We found that the inhibitor of an anion exchange protein, 4,4'-diisothio-cyanatostilbene-2,2'-disulfonate (DIDS), prevented HCO3– use but also had a small effect on CO2 uptake. An inhibitor of external carbonic anhydrase (CA), acetazolamide (AZ), reduced the affinity for CO2 uptake but also prevented HCO3– use via an effect on the anion exchange protein. Analysis of mRNA transcripts identified a homologue of solute carrier 4 (SLC4) responsible for HCO3– transport, likely to be the target of DIDS, and a periplasmic α-carbonic anhydrase 1 (α-CA1). A model to quantify the contribution of the three different pathways involved in inorganic carbon uptake showed that passive CO2 diffusion dominates inorganic carbon uptake at high CO2 concentrations. However, as CO2 concentrations fall, two other pathways become predominant: conversion of HCO3– to CO2 at the plasmalemma by α-CA1 and transport of HCO3– across the plasmalemma by SLC4. These mechanisms allow access to a much larger proportion of the inorganic carbon pool and continued photosynthesis during periods of strong carbon depletion in productive ecosystems.
Level 1 Trauma Centers and OEF/OIF Emergency Departments: Comparison of Trauma Patient Populations
Authors: Savell Shelia C , Blessing Alexis , Shults Nicole M , Mora Alejandra G , Medellin Kimberly L , Muir Mark T , Kester Nurani , Maddry Joseph K 
Published: July 2020

Abstract

Introduction
Brooke Army Medical Center (BAMC), the largest military hospital and the only level 1 trauma center in the DoD, cares for active duty, retired uniformed services personnel, and beneficiaries. In addition, BAMC works in collaboration with the Southwest Texas Regional Advisory Council (STRAC) and University Hospital (UH), San Antonio’s other level 1 trauma center, to provide trauma care to residents of the city and 22 counties in southwest Texas from San Antonio to Mexico (26,000 square mile area). Civilian-military partnerships are shown to benefit the training of military medical personnel; however, to date, there are no published reports specific to military personnel experiences within emergency care. The purpose of the current study was to describe and compare the emergency department trauma patient populations of two level 1 trauma centers in one metropolitan city (BAMC and UH) as well as determine if DoD level 1 trauma cases were representative of patients treated in OEF/OIF emergency department settings.

Materials and Methods
We obtained a nonhuman subjects research determination for de-identified data from the US Air Force 59th Medical Wing and the University of Texas Health Science Center at San Antonio Institutional Review Boards. Data on emergency department patients treated between the years 2015 and 2017 were obtained from the two level 1 trauma centers (BAMC and UH, located in San Antonio, Texas); data included injury descriptors, ICU and hospital days, and department procedures.

Results
Two-proportion Z-tests indicated that trauma patients were similar across trauma centers on injury type, injury severity, and discharge status; yet trauma patients differed significantly in terms of mechanism of injury and regions of injury. BAMC received significantly greater proportions of patients injured from falls, firearms and with facial and head injuries than UH, which received significantly greater proportion of patients with thorax and abdominal injuries. In addition, a significantly greater proportion of patients spent more than 2 days in the ICU and greater than two total hospital days at BAMC than in UH. In comparison to military emergency departments in combat zones, BAMC had significantly lower rates of blood product administration and endotracheal intubations.

Conclusions
The trauma patients treated at a military level 1 trauma center were similar to those treated in the civilian level 1 trauma center in the same city, indicating the effectiveness of the only DoD Level 1 trauma center to provide experience comparable to that provided in civilian trauma centers. However, further research is needed to determine if the exposure rates to specific procedures are adequate to meet predeployment readiness requirements.
Live fast, die young: GMC lifetimes in the FIRE cosmological simulations of Milky Way mass galaxies
Authors: Benincasa Samantha M , Loebman Sarah R , Wetzel Andrew , Hopkins Philip F , Murray Norman , Bellardini Matthew A , Faucher-Giguère Claude-André , Guszejnov Dávid , Orr Matthew 
Published: July 2020

ABSTRACT
We present the first measurement of the lifetimes of giant molecular clouds (GMCs) in cosmological simulations at z = 0, using the Latte suite of FIRE-2 simulations of Milky Way (MW) mass galaxies. We track GMCs with total gas mass ≳105 M⊙ at high spatial (∼1 pc), mass (7100 M⊙), and temporal (1 Myr) resolution. Our simulated GMCs are consistent with the distribution of masses for massive GMCs in the MW and nearby galaxies. We find GMC lifetimes of 5–7 Myr, or 1–2 freefall times, on average, with less than 2 per cent of clouds living longer than 20 Myr. We find decreasing GMC lifetimes with increasing virial parameter, and weakly increasing GMC lifetimes with galactocentric radius, implying that environment affects the evolutionary cycle of GMCs. However, our GMC lifetimes show no systematic dependence on GMC mass or amount of star formation. These results are broadly consistent with inferences from the literature and provide an initial investigation into ultimately understanding the physical processes that govern GMC lifetimes in a cosmological setting.
Constraining a neutron star merger origin for localized fast radio bursts
Authors: Gourdji K , Rowlinson A , Wijers R A M J , Goldstein A 
Published: July 2020

ABSTRACT
What the progenitors of fast radio bursts (FRBs) are, and whether there are multiple types of progenitors are open questions. The advent of localized FRBs with host galaxy redshifts allows the various emission models to be directly tested for the first time. Given the recent localizations of two non-repeating FRBs (FRB 180924 and FRB 190523), we discuss a selection of FRB emission models and demonstrate how we can place constraints on key model parameters such as e magnetic field strength and age of the putative FRB-emitting neutron star. In particular, we focus on models related to compact binary merger events involving at least one neutron star, motivated by commonalities between the host galaxies of the FRBs and the hosts of such merger events/short gamma-ray bursts (SGRBs). We rule out the possibility that either FRB was produced during the final inspiral stage of a merging binary system. Where possible, we predict the light curve of electromagnetic emission associated with a given model and use it to recommend multiwavelength follow-up strategies that may help confirm or rule out models for future FRBs. In addition, we conduct a targeted sub-threshold search in Fermi Gamma-ray Burst Monitor data for potential SGRB candidates associated with either FRB, and show what a non-detection means for relevant models. The methodology presented in this study may be easily applied to future localized FRBs, and adapted to sources with possibly core-collapse supernova progenitors, to help constrain potential models for the FRB population at large.
Wide-angle effects for peculiar velocities
Authors: Castorina Emanuele , White Martin 
Published: July 2020

ABSTRACT
The line-of-sight peculiar velocities of galaxies contribute to their observed redshifts, breaking the translational invariance of galaxy clustering down to a rotational invariance around the observer. This becomes important when the line-of-sight direction varies significantly across a survey, leading to what are known as ‘wide-angle’ effects in redshift-space distortions. Wide-angle effects will also be present in measurements of the momentum field, i.e. the galaxy density-weighted velocity field, in upcoming peculiar velocity surveys. In this work, we study how wide-angle effects modify the predicted correlation function and power spectrum for momentum statistics, both in autocorrelation and in cross-correlation with the density field. Using both linear theory and the Zel'dovich approximation, we find that deviations from the plane-parallel limit are large and could become important in data analysis for low-redshift surveys. We point out that even multipoles in the cross-correlation between density and momentum are non-zero regardless of the choice of line of sight, and therefore contain new cosmological information that could be exploited. We discuss configuration space, Fourier space, and spherical analyses; providing exact expressions in each case rather than relying on an expansion in small angles. We hope these expressions will be of use in the analysis of upcoming surveys for redshift-space distortions and peculiar velocities.
A method for checking high-redshift identification of radio AGNs
Authors: An Tao , Zhang Yingkang , Frey Sándor 
Published: July 2020

ABSTRACT
In large-scale optical spectroscopic surveys, there are many objects found to have multiple redshift measurements due to the weakness of their emission lines and the different automatic identification algorithms used. These include some suspicious high-redshift $(z \gtrsim 5)$ active galactic nuclei (AGNs). Here, we present a method for inspecting the high-redshift identification of such sources provided that they are radio-loud and have very long baseline interferometry (VLBI) imaging observations of their milli-arcsec (mas) scale jet structure available at multiple epochs. The method is based on the determination of jet component proper motions, and the fact that the combination of jet physics (the observed maximal values of the bulk Lorentz factor) and cosmology (the time dilation of observed phenomena in the early Universe) constrain the possible values of apparent proper motions. As an example, we present the case of the quasar J2346 + 0705 that was reported with two different redshifts, z1 = 5.063 and z2 = 0.171, in the literature. We measured the apparent proper motions (μ) of three components identified in its radio jet by utilizing VLBI data taken from 2014 to 2018. We obtained μJ1 = 0.334 ± 0.099 mas yr−1, μJ2 = 0.116 ± 0.029 mas yr−1, and μJ3 = 0.060 ± 0.005 mas yr−1. The maximal proper motion is converted to an apparent transverse speed of $\beta _{\rm app} = 41.2\pm 12.2\, c$, if the source is at redshift 5.063. This value exceeds the blazar jet speeds known to date. This and other arguments suggest that J2346 + 0705 is hosted by a low-redshift galaxy. Our method may be applicable for other high-redshift AGN candidates lacking unambiguous spectroscopic redshift determination or having photometric redshift estimates only, but showing prominent radio jets allowing for VLBI measurements of fast jet proper motions.
Physical conditions in the diffuse interstellar medium of local and high-redshift galaxies: measurements based on the excitation of H2 rotational and C i  fine-structure levels
Authors: Klimenko V V , Balashev S A 
Published: July 2020

ABSTRACT
We present the results of an analysis of the physical conditions (number density, intensity of UV field, kinetic temperature) in the cold H2-bearing interstellar medium of local and high-redshift galaxies. Our measurements are based on the fit to the observed population of H2 rotational levels and C i  fine-structure levels with the help of grids of numerical models calculated with the photon-dominated region (PDR) Meudon code. A joint analysis of low H2 rotational levels and C i  fine-structure levels breaks the degeneracy in the IUV−nH plane and provides significantly tighter constraints on the number density and intensity of the UV field. Using archive data from the VLT/UVES, KECK/HIRES, HST/STIS and FUSE telescopes, we selected 12 high-redshift damped Lyα systems (DLAs) in quasar spectra and 14 H2 absorption systems along the lines of sight towards stars in the Milky Way and the Magellanic Cloud galaxies. These systems have strong H2 components, with a column density log N(H2)/[cm−2] &gt; 18 and associated C i  absorptions. We find that H2-bearing media in high-redshift DLAs and in local galaxies have similar values of the kinetic temperatures Tkin ∼ 100 K and number density 10−500 cm−3. However, the intensity of incident UV radiation in DLAs varies in a wide range (0.1−100 units of the Mathis field), while it is ∼0.1−3 units of the Mathis field for H2 systems in the Milky Way and Large and Small Magellanic Cloud galaxies. The large dispersion of measured UV flux in DLAs is probably a consequence of the fact that the DLA sample probes galaxies selected from the overall galaxy population at high redshift, and therefore corresponds to a wide range of physical conditions.
Iterative removal of redshift-space distortions from galaxy clustering
Authors: Wang Yuchan , Li Baojiu , Cautun Marius 
Published: July 2020

ABSTRACT
Observations of galaxy clustering are made in redshift space, which results in distortions to the underlying isotropic distribution of galaxies. These redshift-space distortions (RSDs) not only degrade important features of the matter density field, such as the baryonic acoustic oscillation (BAO) peaks, but also pose challenges for the theoretical modelling of observational probes. Here, we introduce an iterative non-linear reconstruction algorithm to remove RSD effects from galaxy clustering measurements, and assess its performance by using mock galaxy catalogues. The new method is found to be able to recover the real-space galaxy correlation function with an accuracy of $\sim \!1{{\ \rm per\ cent}}$, and restore the quadrupole accurately to 0, on scales $s\gtrsim 20\,h^{-1}\, {\rm Mpc}$. It also leads to an improvement in the reconstruction of the initial density field, which could help to accurately locate the BAO peaks. An ‘internal calibration’ scheme is proposed to determine the values of cosmological parameters, as a part of the reconstruction process, and possibilities to break parameter degeneracies are discussed. RSD reconstruction can offer a potential way to simultaneously extract the cosmological parameters, initial density field, real-space galaxy positions, and large-scale peculiar velocity field (of the real Universe), making it an alternative to standard perturbative approaches in galaxy clustering analysis, bypassing the need for RSD modelling.
The VMC survey – XXXIX. Mapping metallicity trends in the Small Magellanic Cloud using near-infrared passbands
Authors: Choudhury Samyaday , de Grijs Richard , Rubele Stefano , Bekki Kenji , Cioni Maria-Rosa L , Ivanov Valentin D , van Loon Jacco Th , Niederhofer Florian , Oliveira Joana M , Ripepi Vincenzo 
Published: July 2020

ABSTRACT
We have derived high-spatial-resolution metallicity maps covering ∼42 deg2 across the Small Magellanic Cloud (SMC) in an attempt to understand its metallicity distribution and gradients up to a radius of ∼4○. Using the near-infrared VISTA Survey of the Magellanic Clouds, our data cover a thrice larger area compared with previous studies. We identify red giant branch (RGB) stars in spatially distinct Y, (Y − Ks) colour–magnitude diagrams. In any of our selected subregions, the RGB slope is used as an indicator of the average metallicity, based on calibration to metallicity using spectroscopic data. The metallicity distribution across the SMC is unimodal and can be fitted by a Gaussian distribution with a peak at [Fe/H] = −0.97 dex (σ[Fe/H] = 0.05 dex). We find evidence of a shallow gradient in metallicity (−0.031 ± 0.005 dex deg−1) from the Galactic Centre to radii of 2○–2${_{.}^{\circ}}$5, followed by a flat metallicity trend from ∼3${_{.}^{\circ}}$5 to 4○. We find that the SMC’s metallicity gradient is radially asymmetric. It is flatter towards the east than to the west, hinting at mixing and/or distortion of the spatial metallicity distribution (within the inner 3○), presumably caused by tidal interactions between the Magellanic Clouds.