bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporating staffing instability in the nursing home Five-Star Staffing Composite
Authors: Mukamel Dana B , Saliba Debra , Ladd Heather , Konetzka R Tamara 
Published: December 2024

Abstract
Staffing is an important indicator of nursing home quality and resident health outcomes. The Five-Star staffing ratings in Nursing Home Care Compare, the report card published by the Centers for Medicare and Medicaid Services, is based on average hours per resident-day and turnover measures. Studies have shown that a new measure of staffing instability, capturing day-to-day staffing variation, is associated with resident outcomes and provides additional information about quality not reflected in the current Five-Star staffing ratings. In this paper we simulate the impact of including the new staffing instability measure on staffing ratings for 13 641 nursing homes nationwide, using data for the third quarter of 2023. We found that, under a conservative scenario, 21% of nursing homes perform well or poorly enough on instability that this addition would change their current staffing rating, providing consumers with additional information about quality for these facilities, with minimal disruptions to the rating system as a whole. We also demonstrate that the choice of weights for each of the measures included in the Five-Star ratings matters. These weights should reflect policy priorities. We conclude that the Centers for Medicare and Medicaid Services can and should add staffing instability to its Five-Star staffing ratings.
Major pathologic response predicts survival in resectable stage IIIA non-small cell lung cancer after neoadjuvant therapy
Authors: Zhou Shihong , Zhang Ying , Wu Ziheng , Xia Pinghui , He Tianyu , Cao Jinlin , Lv Wang , Hu Jian 
Published: December 2024

Abstract

OBJECTIVES
Major pathologic response is more common in survival analyses than pathological complete response. Whether major pathologic response can predict survival of patients with resectable stage IIIA non-small cell lung cancer and whether neoadjuvant chemotherapy or immunochemotherapy affect the prognosis of patients remains questionable.

METHODS
Patients with resectable stage IIIA non-small cell lung cancer receiving neoadjuvant chemotherapy (≥2 cycles) with/without immunotherapy were enrolled and divided into two groups according to pathological response. Comparison between the two groups was through chi-square test. Univariate Cox regression analysis and log-rank test were made to identify predictive factors of overall survival and disease-free survival. Kaplan–Meier survival curves were constructed to evaluate the prognostic impact of these factors.

RESULTS
Totally, 38 patients were enrolled. Significant difference was observed in overall survival (P = 0.005) and disease-free survival (P = 0.007) between patients with/without major pathologic response. For patients failing to reach major pathologic response, those who underwent ≥2 cycles of neoadjuvant therapy exhibited improved outcomes in overall survival (P = 0.021) and disease-free survival (P = 0.046). Notably, within this subgroup, patients receiving ≥ 2 cycles of neoadjuvant immunochemotherapy showed a trend towards better overall survival (P = 0.076) and disease-free survival (P = 0.062).

CONCLUSIONS
Major pathologic response can predict survival of patients with resectable stage IIIA non-small cell lung cancer. For patients potentially not achieving major pathologic response after two cycles of neoadjuvant therapy, extended cycles of feasible neoadjuvant therapy are advisable for survival benefits.
Targeting IKZF1 via HDAC1: Combating Acute Myeloid Leukemia
Authors: Balaji Sathyanarayan , Anbarasu Suvitha , Ramaiah Sudha , Anbarasu Anand 
Published: December 2024

Abstract
Acute myeloid leukemia (AML) accounts for 1.3% of all cancers, with a limited survival of only 30%, and treating AML is a continuous challenge in medicine. IKZF1 is a DNA-binding protein that is highly mutated and undruggable but significant in causing AML. The current study aims to target its transcription factors (TFs) modulating IKZF1 activity. The TF network was constructed and analyzed which revealed a dense Markov cluster (MCL) cluster and five hub genes namely, HDAC1, EP300, CREBBP, TP53, and MYC; the first node clusters were generated for the hub genes. Functional enrichment analysis found AML pathway enriched in all the clusters. Gene ontology terms were majorly related to transcription regulation terms including RNA polymerase transcription regulation, DNA binding activity, DNA templated transcription, and transcription factor binding. Further, the mutation profile of all the TFs found HDAC1 with a very low mutation profile of 0.1% and the survival plot found HDAC1 with a hazard ratio of 1.17 with increased survival upon low expression. Also, among the hub genes, HDAC1 was the only first node interactor with IKZF1. Thus, HDAC1 could be a potential biomarker candidate as well as a key target in treating AML.
Insight Box The study has an integrated approach for identifying a potential target through network analysis, functional enrichment analysis, mutation profiling survival prognosis, and target screening. The study employs a better strategy for targeting IKZF1, a significantly upregulated gene in AML by regulating its transcription factors. The analysis revealed a network of TFs regulating IKZF1, among which HDAC1 emerged as a promising candidate due to its low mutation rate, association with better survival outcomes, and direct interaction with IKZF1. This suggests HDAC1 could be a valuable biomarker and therapeutic target for AML treatment.
Dengue and diabetes comorbidity: an emerging public health threat
Authors: Bisanzio Donal , Estofolete Cássia Fernanda , Reithinger Richard 
Published: December 2024

Abstract
Dengue is of growing global public health concern. Diabetes is a significant risk factor for severe dengue and dengue-related mortality. Countries with the highest number of reported dengue cases are projected to experience a substantial increase in diabetes by 2050. This likely will result in an increased incidence of dengue–diabetes comorbidity, and, hence, in severe dengue and dengue-related mortality. Countries that are or will be affected by a high burden for both diabetes and dengue should urgently design strategies to minimize the health and economic impact that a diabetes–dengue comorbidity could have on affected populations.
The selective estrogen receptor modulator clomiphene inhibits sterol biosynthesis in Arabidopsis thaliana
Authors: Wang Qing , De Vriese Kjell , Desmet Sandrien , Wang Ren , Luklová Markéta , Liu Qianqian , Pollier Jacob , Lu Qing , Schlag Sarah , Vetter Walter , Goossens Alain , Russinova Eugenia , Goeminne Geert , Geelen Danny , Beeckman Tom , Vanneste Steffen 
Published: December 2024

Abstract
Sterols are produced via complex, multistep biosynthetic pathways involving similar enzymatic conversions in plants, animals, and fungi, yielding a variety of sterol metabolites with slightly different chemical properties to exert diverse and specific functions. A tremendously diverse landscape of sterols, and sterol-derived compounds can be found across the plant kingdom, determining a wide spectrum of functions. Resolving the underlying biosynthetic pathways is thus instrumental to understanding the function and use of these molecules. In only a few plants, sterol biosynthesis has been studied using mutants. In non-model species, a pharmacological approach is required. However, this relies on only a few inhibitors. Here, we investigated a collection of inhibitors of mammalian cholesterol biosynthesis to identify new inhibitors of plant sterol biosynthesis. We showed that imidazole-type fungicides, bifonazole, clotrimazole, and econazole, inhibited the obtusifoliol 14α-demethylase CYP51 in plants. Moreover, we found that the selective estrogen receptor modulator, clomiphene, inhibited sterol biosynthesis in part by inhibiting the plant-specific cyclopropyl-cycloisomerase CPI1. These results demonstrate that rescreening of inhibitors of animal sterol biosynthesis is an easy approach for identifying novel inhibitors of plant sterol biosynthesis. The molecules used in this study expand the range of inhibitors for studying and manipulating sterol biosynthesis in the plant kingdom.
Ivosidenib for the treatment of IDH1-mutant glioma, grades 2–4: Tolerability, predictors of response, and outcomes
Authors: Lanman Tyler A , Youssef Gilbert , Huang Raymond , Rahman Rifaquat , DeSalvo Matthew , Flood Thomas , Hassanzadeh Elmira , Lang Min , Lauer Jason , Potter Christopher , Jiao Albert , Pan Ian , Cahill Daniel P , Lan Zhou , Ospina Juan Pablo , Nakhate Vihang , Stec Natalie E , Shi Diana , Bi Wenya Linda , McBrayer Samuel K , Arrillaga-Romany Isabel , Lee Eudocia Q , Chukwueke Ugonma N , Nayak Lakshmi , Forst Deborah A , Gerstner Elizabeth R , Jordan Justin T , Dietrich Jorg , Miller Julie , Batchelor Tracy T , Reardon David A , Wen Patrick Y , Gonzalez Castro L Nicolas 
Published: December 2024

Abstract

Background
Mutant isocitrate dehydrogenase (IDHm) inhibitors represent a novel targeted approach for treating IDHm glioma patients, yet their optimal use in clinical practice outside of clinical trials remains undefined. This study describes the real-world utilization of the mutant IDH1 inhibitor (IDHi), ivosidenib, in patients with IDHm glioma.

Methods
We retrospectively reviewed clinical and radiographic data from patients with IDHm glioma treated with ivosidenib monotherapy from 2020 to 2024 at the Dana-Farber Cancer Institute and Massachusetts General Hospital.

Results
This cohort included 74 patients with a median age of 39. There were 35 astrocytomas and 39 oligodendrogliomas, with 49, 23, and 2, grade 2, 3, and 4 tumors, respectively. Nineteen patients (26%) experienced an adverse event, although only 1 patient discontinued ivosidenib for adverse events. Median progression-free survival was 31 months and median overall survival was not reached. Seven patients (9%) had partial response, 3 (4%) had minor response, 47 (64%) had stable disease, and 17 (23%) had progressive disease. The presence of enhancing disease at ivosidenib initiation was associated with lower disease control rates (DCR) whereas DCR differences were not detected based on grade (grade 2 vs. 3), tumor histology, or age. Subsequent-line ivosidenib use had lower DCR although this may have been explained by enrichment of patients with enhancing disease.

Conclusions
In this large cohort of IDHm glioma patients, ivosidenib was well tolerated. Our results support the use of IDHi therapy in patients with grade 2 or 3 astrocytoma or oligodendroglioma and highlight limited effectiveness in patients with enhancing disease.
Experiencing pain: perspectives of Patrick D. Wall—founding editor of the journal PAIN
Authors: Devor Marshall 
Published: December 2024

Abstract
Pain is a sensory and emotional experience. How did Pat Wall, founding editor of the journal PAIN and recognized pain guru, view the relation between the brain and the experience of pain? He was certain what it is not. It is not impulses in peripheral nociceptors that light up neurons in a central pain nucleus. Rather, it is a complex “signature” of brain activity normally driven by sensory stimuli, but in the event of pathology also from ectopic sources in injured nerves and associated dorsal root ganglia. Pain signatures are modulated in many ways: suppressed by gate control and descending brain pathways, augmented by peripheral and central sensitization, and massaged by abundant central feedback and feedforward loops. Pain experience is a complex function of a conscious brain. Ultimately, to understand pain is to understand conscious perception.
The impact of the “treasure game” on geometric thinking and post-learning mood in first-grade children
Authors: Chikha Anis Ben , Hawani Aymen , Eken Özgür , Goumni Chiraz , Zoghlami Wael , Mrayeh Maher , Kurtoğlu Ahmet , Souissi Nizar , Aldhahi Monira I. 
Published: December 2024

Background:
This study aimed to investigate the effect of the motor game “Treasure Game” (TG) on first-grade children’s level of geometric thinking and post-learning mood tracking (PLMT).

Methods:
The study employed 24 first-grade children aged 6.1 ± 0.7 years from a public primary school in Tunisia, all classified at Level 1 of van Hiele geometric thinking (GT). Participants were randomly in a counterbalanced, randomized crossover design in 2 groups and engaged in both the TG during physical education sessions and the conventional geometry course (CGC) during mathematics sessions over a 3-week period, with sessions counterbalanced to avoid order effects. The Van Hiele geometry test was administered to assess GT, and a mood chart was used to track PLMT. Data were analyzed using the SPSS software (Chicago), applying paired and independent samples t-tests to compare the effects of TG and CGC on GT and mood, with significance set at P < .05 and effect sizes calculated using Cohen D and Hedges g.

Results:
The results indicated that the TG had a significant positive impact on both GT and PLMT in first-grade children. In group 1, there was no significant difference in GT after the CGC compared to TG; however, group 2 showed a significant improvement in GT after TG compared to CGC, with a large effect size. Additionally, PLMT scores were significantly higher after TG than after CGC in both groups, with mood scores increasing when transitioning from CGC to TG and decreasing when transitioning from TG to CGC. Overall, the data demonstrate that TG significantly enhances both cognitive and emotional outcomes in young learners compared to traditional geometry instruction.

Conclusion:
The study confirms that participation in the TG significantly enhances GT and improves post-learning mood in first-grade children. This suggests that integrating motor activities like TG into the curriculum could be a viable strategy for enhancing early geometric education. Further research with larger sample sizes and considerations of gender differences is recommended.
The impact of scarcity promotions in live streaming e-commerce on purchase intention: the mediating effect of emotional experience
Authors: Zhou Rong 
Published: December 2024

PurposeThis article investigates the impact mechanism of scarcity promotions in live streaming e-commerce on consumer purchase intention in the context of urban-rural and male-female divides in China, with emotional experience as the mediating variable.Design/methodology/approachA total of 687 online questionnaires are collected, and the model is empirically analyzed by partial least squares structural equation model.FindingsScarcity promotions in live streaming e-commerce positively influence purchase intention, with emotional experience mediating the impact. Furthermore, the influence of scarcity promotions in live streaming e-commerce on the emotional experience of urban residents is greater than that of rural residents. The effect of scarcity promotions on the purchase intention of urban residents is lower than that of rural residents. Scarcity promotions in live streaming e-commerce have a greater impact on the emotional experience of female consumers compared to male consumers. The influence of scarcity promotions on the purchase intention of female consumers is lower than that of male consumers.Originality/valueThis article extends the scarcity promotion theory to the context of live streaming e-commerce. Furthermore, it is the first to explore the mediating role of emotional experience in this process. Lastly, it is the first to investigate the moderating effects of urban-rural and male-female factors in this process.
Failed products, successful influencers: the moderating effect of the stealing thunder strategy on purchase intentions in live-streaming e-commerce failures
Authors: Lu Pingjun , Fang Lin , Chen Qiying , Ma Xujie 
Published: December 2024

PurposeA live-stream failure occurs when the product which is highly recommended by the influencers and exhibited quality problems. This study investigated how brand trust and influencers trust affect live-streaming purchase intentions (PIs) of consumers when live-streaming e-commerce failures occur and the role of the Stealing Thunder (ST).Design/methodology/approachTotally 584 adults with live-streaming shopping experience were invited to investigate the impact and mechanisms of live-streaming failure incidents, as well as the moderating mechanisms of ST.FindingsFirstly, live-streaming failure accidents decreased the PI of consumers by reducing both brand trust and influencer trust, with trust in the influencers having a stronger impact on PI than brand trust. Secondly, if the influencers used the ST after a live-stream failure, the PI was the same as that in a non-failure scenario. Thirdly, the ST acts as a moderating variable neutralized the negative impact of live-streaming failure on trust in the influencers. Lastly, the negative impact of brand trust on PI was less significant using the ST.Originality/valueThis research deepens the understanding of service failures in live-streaming e-commerce. It provides insights into the consumer behavior and practical guidance on how influencers can actively respond to live-streaming failure to sustain reciprocal relationships in live-streaming e-commerce. The study addresses the effects of the coping strategies of influencers on the interests of product brands and discusses the potential solutions.
How to unlock BIM capabilities in the design phase to project success for long-term organization development?
Authors: Araujo Cleber Marchi Bernardo de , Alves Josivan Leite 
Published: December 2024

PurposeExplore how the AECO organizations can establish BIM capabilities in the design phase to ensure project success for long-term development.Design/methodology/approachQuantitative approach through the application of structural equation modeling with the partial least squares method (PLS-SEM). This study performs a path analysis and hypothesis testing through the PLS method using the SmartPLS 4.0 software.FindingsThe paper demonstrates that simply adopting BIM is not enough for project success. The lack of preparation for adopting BIM can even have a negative effect on project success, since the structure, technology and designers may not be prepared to integrate all project requirements into BIM models. For effective project success, the article demonstrates that the indirect effect of building BIM capabilities must be considered.Research limitations/implicationsThe proposed model can serve as a guide for organizational strategy by showing managers the main variables to be considered for long-term survival. The article also warns that the isolated adoption of BIM can be detrimental to the success of projects. However, the lack of BIM capabilities can exclude the organization from the market, as it may not be prepared to recognize project opportunities and not incorporate technologies.Practical implicationsThe limitation is that the data are not longitudinal; therefore, they are conditioned by the current perceptions of AECO industry professionals about BIM adoption. The results of this research reflect the perception of professionals in the Brazilian construction industry only.Social implicationsAlthough social implications are not directly addressed in the model, the potential for improving project success in the AECO industry suggests broader positive impacts on project management in the AECO industry. Furthermore, these advances can contribute to better urban planning, improved infrastructure and overall social well-being, impacting quality of life by influencing public policy and shaping public attitudes toward construction and development.Originality/valueUsing strategic innovation theories as a theoretical framework for building BIM capabilities, the paper expands this theory by establishing that BIM capabilities are fundamental to sustaining the survival of AECO industry organizations. The paper demonstrates that BIM capabilities are what prepare organizations to adapt to new technologies and strategic resources oriented toward innovation. In this sense, the adoption of BIM itself is an initial step towards building these capabilities, since once the adaptation phase is over, the organization is prepared to optimize its processes with other technologies.
Unpacking talent management: a moderated mediation analysis of team dynamics and competitive performance in luxury hotels
Authors: Zaki Karam , Elnagar Ahmed K. 
Published: December 2024

PurposeThis article seeks to examine how structural alignment (SA) and guided governance (GG), key components of team management (TT), mediate the connection between talent management (TM) and the competitive performance (CP) of hotels.Design/methodology/approachThe study employed a quantitative methodology by administering surveys to 330 hotel executives in Egypt to gather the necessary data. To examine the research hypotheses, partial least squares-structural equation modeling was utilized.FindingsTalent management mindset (TMM) and talent management strategy (TMS) are closely connected to team management (TT) and CP. Both SA and GG play a considerable role in mediating the relationship between TM and CP. Additionally, the impact of strategic incentives (SI) moderator in shaping the connection between TM and CP has been validated.Research limitations/implicationsThis research is part of a small collection of studies that examines TM, TT and CP in a practical manner. The scope of this study is focused on luxury hotels located in Egypt. It contributes to the field by expanding our understanding of TM, TT and the multifaceted nature of a hotel’s CP, an important but often overlooked concern, particularly within the Egyptian context. Additionally, it suggests numerous possibilities for further investigation in the future.Originality/valueThis study is among the initial research works that emphasize a moderated mediated model of TM, TT, SI and hotels’ competitive performance in Egypt.