bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional differences in the capitalisation of first and second pillar payments of the CAP into land rental prices
Authors: Salhofer Klaus , Feichtinger Paul 
Published: September 2020

Abstract
Nearly 80 per cent of Common Agricultural Policy (CAP) expenditures are spent on three different measures: first pillar payments (FPPs), agri-environmental payments (AEPs) and less favoured area payments (LFAPs). Based on a dynamic panel model and farm accounting data for Bavaria, we find that, on average, 30 per cent of FPPs, 40–50 per cent of LFAPs, but no relevant share of AEPs are capitalised into land rental prices. The capitalisation ratio varies considerably across regions. Above average capitalisation ratios for FPPs are observed in more favourable areas with high yields, a low grassland share and large farms. The same is true for LFAPs for areas with high yields, large farms and a greater share of part-time farmers.
Pseudo-probabilistic identification of fracture network in seismic clouds driven by source parameters
Authors: Koepke Rike , Gaucher Emmanuel , Kohl Thomas 
Published: September 2020

SUMMARYFracture networks in underground reservoirs are important pathways for fluid flow and can therefore be a deciding factor in the development of such reservoirs for geothermal energy, oil and gas production or underground storage. Yet, they are difficult to characterize since they usually cannot be directly accessed. We propose a new method to compute the likelihood of having a fracture at a given location from induced seismic events and their source parameters. The result takes the form of a so-called pseudo-probabilistic fracture network (PPFN). In addition to the hypocentres of the seismic events used to image the fracture network, their magnitudes and focal mechanisms are also taken into account, thus keeping a closer link with the geophysical properties of the rupture and therefore the geology of the reservoir. The basic principle of the PPFN is to estimate the connectivity between any spatial position in the cloud and the seismic events. This is done by applying weighting functions depending on the distance between a seismic event and any location, the minimum size of the rupture plane derived from the event magnitude, and the orientation of the rupture plane provided by the focal mechanism. The PPFN is first tested on a set of synthetic data sets to validate the approach. Then, it is applied to the seismic cloud induced by the deep hydraulic stimulation of the well GPK2 of the enhanced geothermal site of Soultz-sous-Forêts (France). The application on the synthetic data sets shows that the PPFN is able to reproduce fault planes placed in a cloud of randomly distributed events but is sensitive to the free parameters that define the shape of the weighting functions. When these parameters are chosen in accordance with the scale of investigation, that is, the typical size of the structures of interest, the PPFN is able to determine the position, size and orientation of the structure quite precisely. The application of the PPFN to the GPK2 seismic cloud reveals a large prominent fault in the deep-northern part of the seismic cloud, supporting conclusions from previous work, and a minor structure in the southern upper part, which could also be a branch of the main fault.
Epigenome-wide association study of diet quality in the Women’s Health Initiative and TwinsUK cohort
Authors: Do Whitney L , Whitsel Eric A , Costeira Ricardo , Masachs Olatz M , Le Roy Caroline I , Bell Jordana T , Staimez Lisa R , Stein Aryeh D , Smith Alicia K , Horvath Steve , Assimes Themistocles L , Liu Simin , Manson JoAnn E , Shadyab Aladdin H , Li Yun , Hou Lifang , Bhatti Parveen , Jordahl Kristina , Narayan K M Venkat , Conneely Karen N 
Published: September 2020

Abstract

Background
Diet quality is a risk factor for chronic disease and mortality. Differential DNA methylation across the epigenome has been associated with chronic disease risk. Whether diet quality is associated with differential methylation is unknown. This study assessed whether diet quality was associated with differential DNA methylation measured across 445 548 loci in the Women’s Health Initiative (WHI) and the TwinsUK cohort.

Design
The discovery cohort consisted of 4355 women from the WHI. The replication cohort consisted of 571 mono- and dizygotic twins from the TwinsUK cohort. DNA methylation was measured in whole blood using the Illumina Infinium HumanMethylation450 Beadchip. Diet quality was assessed using the Alternative Healthy Eating Index 2010 (AHEI-2010). A meta-analysis, stratified by study cohort, was performed using generalized linear models that regressed methylation on AHEI-2010, adjusting for cell composition, chip number and location, study characteristics, principal components of genetic relatedness, age, smoking status, race/ethnicity and body mass index (BMI). Statistical significance was defined as a false discovery rate &lt; 0.05. Significant sites were tested for replication in the TwinsUK cohort, with significant replication defined by P &lt; 0.05 and a consistent direction.

Results
Diet quality was significantly associated with differential DNA methylation at 428 cytosine-phosphate-guanine (CpG) sites in the discovery cohort. A total of 24 CpG sites were consistent with replication in the TwinsUK cohort, more than would be expected by chance (P = 2.7x10-4), with one site replicated in both the blood and adipose tissue (cg16379999 located in the body of SEL1L).

Conclusions
Diet quality was associated with methylation at 24 CpG sites, several of which have been associated with adiposity, inflammation and dysglycaemia. These findings may provide insight into pathways through which diet influences chronic disease.
Analysis of Inpatient and Emergency Department Serial Troponin Testing Intervals in the United States
Authors: Fletcher Andrew , Forsman Erik , Jackson Brian R 
Published: September 2020

Abstract

Background
Serial measurement of cardiac troponins (cTn) is central to the diagnosis of myocardial infarction. The time intervals between individual measurements may impact the speed and reliability of diagnosis. Published recommendations exist for these time intervals, but there is little previously published data on actual intervals in routine clinical settings.

Methods
Retrospective analysis of cTn testing intervals was performed from a convenience sample of 37 hospitals. All 37 provided data on inpatient tests and 19 also provided separate data for tests ordered in their emergency departments. Facilities included both academic and community hospitals across the United States. For each facility, the median time interval between serial cTn order collections was determined separately for inpatient orders and emergency department orders.

Results
The facility-level median time intervals between serial inpatient cTn test orders ranged from 3.17 to 7.32 hours. Facility-level median time intervals between serial emergency department cTn orders ranged from 1.48 to 4.23 hours. There was no observed difference between academic and nonacademic facilities.

Conclusion
Typical time intervals between serial cTn orders varied widely across hospitals, and in many cases reflected suboptimal care. Time intervals were generally shorter for cTn testing ordered in emergency departments. Existing testing protocols should be re-examined.
Disorder and Downsizing
Authors: Ross Gretchen R , Meloy Margaret G , Bolton Lisa E 
Published: September 2020

AbstractThe consequences of overconsumption and the recent popularity of simple living point to consumer interest in reducing belongings. They also raise an interesting question—what is a useful approach to downsizing and decluttering? We investigate how dis/order (messy vs. tidy items) affects downsizing and find, across nine focal studies, that (a) consumers retain fewer items when choosing from a disordered set because (b) order facilitates the comparisons within category that underlie the tendency to retain items. The impact of dis/order is altered by consumers’ comparison tendencies, waste aversion, and decision strategy (selection vs. rejection), which serve as theoretically and pragmatically relevant moderators. Though consumers’ lay beliefs favor rejecting from order (i.e., choosing what to get rid of from tidy items), our findings point to the usefulness of selecting from disorder (i.e., choosing what to keep from messy items) as a downsizing strategy. Together, this research has implications for consumer downsizing activities, the burgeoning home organization and storage industries, as well as sustainability.
COVID-19, Social Justice, and Clinical Cancer Research
Authors: Doroshow James H , Prindiville Sheila , McCaskill-Stevens Worta , Mooney Margaret , Loehrer Patrick J 
Published: September 2020

Abstract
The coronavirus disease 2019 (COVID-19) pandemic and related socioeconomic events have markedly changed the environment in which cancer clinical trials are conducted. These events have resulted in a substantial, immediate-term decrease in accrual to both diagnostic and therapeutic cancer investigations as well as substantive alterations in patterns of oncologic care. The sponsors of clinical trials, including the US National Cancer Institute, as well as the cancer centers and community oncology practices that conduct such studies, have all markedly adapted their models of care, usage of healthcare personnel, and regulatory requirements in the attempt to continue clinical cancer investigations while maintaining high levels of patient safety. In doing so, major changes in clinical trials practice have been embraced nationwide. There is a growing consensus that the regulatory and clinical research process alterations that have been adopted in response to the pandemic (such as the use of telemedicine visits to reduce patient travel requirements and the application of remote informed consent procedures) should be implemented long term. The COVID-19 outbreak has also refocused the oncologic clinical trials community on the need to bring clinical trials closer to patients by dramatically enhancing clinical trial access, especially for minority and underserved communities that have been disproportionately affected by the pandemic. In this commentary, changes to the program of clinical trials supported by the National Cancer Institute that could improve clinical trial availability, effectiveness, and diversity are proposed.
Specificity, Conflict, and Focal Point: A Systematic Investigation into Social Media Censorship in China
Authors: Tai Yun , Fu King-wa 
Published: September 2020

Abstract
Internet censorship mechanisms in China are highly dynamic and yet to be fully accounted for by existing theories. This study interrogates postpublication censorship on Chinese social media by examining the differences between 2,280 pairs of censored WeChat articles and matched remaining articles. With the effects of account attributes and article topics excluded, we find that article specificity raises the odds of being censored. Also, an examination on a collection of international trade articles indicates that such articles with textual units disclosing conflicts, even pro-regime messages, are also removed by the censors. This mixed-method study introduces focal point as a theoretical angle to understand China’s contextually contingent content regulation system and offers evidence based on large-scale, nonproprietary, and original social media data to investigate the evolving censorship mechanisms in China.
Health Care Utilization, Transition Readiness, and Quality of Life: A Latent Class Analysis
Authors: Traino Katherine A , Sharkey Christina M , Perez Megan N , Bakula Dana M , Roberts Caroline M , Chaney John M , Mullins Larry L 
Published: September 2020

AbstractObjectiveTo identify possible subgroups of health care utilization (HCU) patterns among adolescents and young adults (AYAs) with a chronic medical condition (CMC), and examine how these patterns relate to transition readiness and health-related quality of life (HRQoL).MethodsUndergraduates (N = 359; Mage=19.51 years, SD = 1.31) with a self-reported CMC (e.g., asthma, allergies, irritable bowel syndrome) completed measures of demographics, HCU (e.g., presence of specialty or adult providers, recent medical visits), transition readiness, and mental HRQoL (MHC) and physical HRQoL (PHC). Latent class analysis identified four distinct patterns of HCU. The BCH procedure evaluated how these patterns related to transition readiness and HRQoL outcomes.ResultsBased on seven indicators of HCU, a four-class model was found to have optimal fit. Classes were termed High Utilization (n = 95), Adult Primary Care Physician (PCP)-Moderate Utilization (n = 107), Family PCP-Moderate Utilization (n = 81), and Low Utilization (n = 76). Age, family income, and illness controllability predicted class membership. Class membership predicted transition readiness and PHC, but not MHC. The High Utilization group reported the highest transition readiness and the lowest HRQoL, while the Low Utilization group reported the lowest transition readiness and highest HRQoL.ConclusionsThe present study characterizes the varying degrees to which AYAs with CMCs utilize health care. Our findings suggest poorer PHC may result in higher HCU, and that greater skills and health care engagement may not be sufficient for optimizing HRQoL. Future research should examine the High Utilization subgroup and their risk for poorer HRQoL.
Supporting Caregivers of Children with ADHD
Authors: Chronis-Tuscano Andrea , O'Brien Kelly , Danko Christina M. 
Published: September 2020

Abstract
Although the causes of attention-deficit/hyperactivity disorder (ADHD) are largely neurobiological and genetic, the manner in which parents respond to their child’s challenging behaviors can influence both the severity and developmental course of the child’s difficulties. What makes this more challenging for many families is that ADHD and many of the problems that go along with it are highly heritable, making it even harder for many parents of children with ADHD to create the consistent, calm, and organized environment in which the child with ADHD is most likely to thrive. Even parents with the very best intentions may not have the self-regulation skills, motivation, persistence, or organization to do what the authors’ evidence-based interventions require. Until now, few interventions for ADHD have given adequate attention to this very important issue, and none has integrated the focus on parent mental health and parenting in exactly the way the authors do in this program.
A full characterization of the supermassive black hole in IRAS 09149–6206
Authors: Walton D J , Alston W N , Kosec P , Fabian A C , Gallo L C , Garcia J A , Miller J M , Nardini E , Reynolds M T , Ricci C , Stern D , Dauser T , Harrison F A , Reynolds C S 
Published: September 2020

ABSTRACTWe present new broad-band X-ray observations of the type-I Seyfert galaxy IRAS 09149–6206, taken in 2018 with XMM–Newton, NuSTAR, and Swift. The source is highly complex, showing a classic ‘warm’ X-ray absorber, additional absorption from highly ionized iron, strong relativistic reflection from the innermost accretion disc and further reprocessing by more distant material. By combining X-ray timing and spectroscopy, we have been able to fully characterize the supermassive black hole in this system, constraining both its mass and – for the first time – its spin. The mass is primarily determined by X-ray timing constraints on the break frequency seen in the power spectrum, and is found to be log [MBH/M⊙] = 8.0 ± 0.6 (1σ uncertainties). This is in good agreement with previous estimates based on the H α and H β line widths, and implies that IRAS 09149–6206 is radiating at close to (but still below) its Eddington luminosity. The spin is constrained via detailed modelling of the relativistic reflection, and is found to be $a^* = 0.94^{+0.02}_{-0.07}$ (90 per cent confidence), adding IRAS 09149–6206 to the growing list of radio-quiet active galactic nuclei (AGNs) that host rapidly rotating black holes. The outflow velocities of the various absorption components are all relatively modest (vout ≲ 0.03c), implying these are unlikely to drive significant galaxy-scale AGN feedback.
Classifying image sequences of astronomical transients with deep neural networks
Authors: Gómez Catalina , Neira Mauricio , Hernández Hoyos Marcela , Arbeláez Pablo , Forero-Romero Jaime E 
Published: September 2020

ABSTRACT
Supervised classification of temporal sequences of astronomical images into meaningful transient astrophysical phenomena has been considered a hard problem because it requires the intervention of human experts. The classifier uses the expert’s knowledge to find heuristic features to process the images, for instance, by performing image subtraction or by extracting sparse information such as flux time-series, also known as light curves. We present a successful deep learning approach that learns directly from imaging data. Our method models explicitly the spatiotemporal patterns with deep convolutional neural networks and gated recurrent units. We train these deep neural networks using 1.3 million real astronomical images from the Catalina Real-Time Transient Survey to classify the sequences into five different types of astronomical transient classes. The TAO-Net (for Transient Astronomical Objects Network) architecture outperforms the results from random forest classification on light curves by 10 percentage points as measured by the F1 score for each class; the average F1 over classes goes from $45{{\ \rm percent}}$ with random forest classification to $55{{\ \rm percent}}$ with TAO-Net. This achievement with TAO-Net opens the possibility to develop new deep learning architectures for early transient detection. We make available the training data set and trained models of TAO-Net to allow for future extensions of this work.
Jet feedback and the photon underproduction crisis in simba
Authors: Christiansen Jacob F , Davé Romeel , Sorini Daniele , Anglés-Alcázar Daniel 
Published: September 2020

ABSTRACT
We examine the impact of black hole jet feedback on the properties of the low-redshift intergalactic medium (IGM) in the simba simulation, with a focus on the Lyα forest mean flux decrement DA. Without jet feedback, we confirm the photon underproduction crisis (PUC) in which ΓH i at $z$ = 0 must be increased by 6 times over the Haardt & Madau value in order to match the observed DA. Turning on jet feedback lowers this discrepancy to ∼2.5 times, and additionally using the recent Faucher–Giguère background mostly resolves the PUC, along with producing a flux probability distribution function in accord with observations. The PUC becomes apparent at late epochs ($z \lesssim 1$) where the jet and no-jet simulations diverge; at higher redshifts simba reproduces the observed DA with no adjustment, with or without jets. The main impact of jet feedback is to lower the cosmic baryon fraction in the diffuse IGM from 39 per cent to 16 per cent at $z$ = 0, while increasing the warm-hot intergalactic medium (WHIM) baryon fraction from 30 per cent to 70 per cent; the lowering of the diffuse IGM content directly translates into a lowering of DA by a similar factor. Comparing to the older mufasa simulation that employs different quenching feedback but is otherwise similar to simba, mufasa matches DA less well than simba, suggesting that low-redshift measurements of DA and ΓH i could provide constraints on feedback mechanisms. Our results suggest that widespread IGM heating at late times is a plausible solution to the PUC, and that simba’s jet active galactic nucleus feedback model, included to quench massive galaxies, approximately yields this required heating.
Morphology of radio relics – I. What causes the substructure of synchrotron emission?
Authors: Domínguez-Fernández P , Brüggen M , Vazza F , Banda-Barragán W E , Rajpurohit K , Mignone A , Mukherjee D , Vaidya B 
Published: September 2020

ABSTRACT
High-resolution radio observations of cluster radio relics often show complex spatial and spectral features. However, it is not clear what these features reveal about the underlying magnetic field properties. We performed three-dimensional magnetohydrodynamical simulations of merger shock waves propagating through a magnetized, turbulent intracluster medium. Our model includes the diffusive shock acceleration (DSA) of cosmic ray electrons, their spatial advection and energy losses at run-time. With this set-up we can investigate the relation between radio substructure and pre-shock plasma conditions in the host cluster. We find that upstream turbulence plays a major role in shaping the properties of radio relics produced downstream. Within the assumption of DSA, we can reproduce the observed discrepancy between the X-ray derived Mach number of shocks, and the Mach number inferred from radio spectra. Our simulated spectral index maps and profiles across the radio relic also suggest that the standard deviation of the upstream magnetic field must be relatively small ($\sigma _B\le 1 \, \mu$G) in order to reproduce observations and therefore radio relics can potentially constrain the distribution of magnetic fields in galaxy clusters outskirts.
Development of aptamer-based inhibitors for CRISPR/Cas system
Authors: Zhao Jing , Inomata Rika , Kato Yoshio , Miyagishi Makoto 
Published: September 2020

AbstractThe occurrence of accidental mutations or deletions caused by genome editing with CRISPR/Cas9 system remains a critical unsolved problem of the technology. Blocking excess or prolonged Cas9 activity in cells is considered as one means of solving this problem. Here, we report the development of an inhibitory DNA aptamer against Cas9 by means of in vitro selection (systematic evolution of ligands by exponential enrichment) and subsequent screening with an in vitro cleavage assay. The inhibitory aptamer could bind to Cas9 at low nanomolar affinity and partially form a duplex with CRISPR RNA, contributing to its inhibitory activity. We also demonstrated that improving the inhibitory aptamer with locked nucleic acids efficiently suppressed Cas9-directed genome editing in cells and reduced off-target genome editing. The findings presented here might enable the development of safer and controllable genome editing for biomedical research and gene therapy.