bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Non-governmental Organizations in Community-based COVID-19 Education: A Qualitative Study in South Africa and Zambia
Authors: Johnston Jamie , Aluri Kelly Zhang , Kuhnert Kira-Leigh , Job Nophiwe , Prober Charles 
Published: December 2020

Abstract
BackgroundEnsuring access to accurate and actionable health information is crucial during the COVID-19 pandemic, especially in low-resource settings. Among marginalized groups, there are disparities in access to information, along with significant mistrust of government sources. Non-governmental organizations (NGOs) involved in community-level health education can play an important role in bridging mistrust and targeting information to reach vulnerable populations. There is a lack of research on the experiences and needs of organizations involved in disseminating health information during the pandemic. MethodsThis study uses a qualitative approach to investigate the current strategies, challenges, and needs of community-based organizations involved in COVID-19 public education. From May to June 2020, we conducted 19 semi-structured interviews with leaders of organizations in South Africa and Zambia. Participants were asked a series of open-ended questions in three domains: 1) the impact of the pandemic on the communities served by the organization, 2) their COVID-19 response, and 3) organization needs and challenges during the pandemic. Interviews were recorded, transcribed, and coded using thematic analysis. Coding and analysis were conducted by four study authors and every interview was independently coded by 2 separate authors to maximize internal validity and consistency.Results5 themes relevant to the roles and challenges of locally active NGO’s were identified: (1) they intimately understand community needs during the pandemic; (2) they adapt to pandemic constraints to continue supporting vulnerable populations; (3) they play a unique role in educating the public about COVID-19 due to established access and trust within communities; (4) they are able to customize health education and information to address nuanced needs of local communities served; and (5) they need external support to effectively respond to the pandemic.ConclusionsOverall, our study contributes a deeper understanding of the role of NGOs in providing needed support and customized health education for vulnerable communities during a global public health crisis. To maximize their ability to support their communities, NGO’s would benefit from access to educational resources designed to be easily modified, support in navigating technological and safety challenges during the pandemic, and sustainable funding.
Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis
Authors: Jin Shuqing , Ding Xibing , Yang Chenxuan , Li Wenbo , Deng Meihong , Liao Hong , Pitt Bruce R. , Billiar Timothy R. , Zhang Li-Ming , Li Quan 
Published: December 2020

Abstract
Background: The mechanisms by which moderate tidal volume ventilation (MTV) may exacerbate preexisting lung injury remain unclear. We hypothesized that in two hit model (polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of dsRNA and MTV), systemic endotoxemia via gut-lung axis would lead to non-canonical (i.e. caspase-11 dependent) and canonical (caspase-1 dependent) inflammasome activation and programmed necrotic cell death (pyroptosis) contributing to acute lung injury (ALI) in intact mice.Methods: Anesthetized mice were administered Poly(I:C) intratracheally and then 6 h later, they were mechanically ventilated for 4 h with otherwise non-injurious MTV (10ml/kg). Changes in intestinal and alveolar capillary permeability were measured. Further documentation of ALI was assessed by evans blue albumin permeability, protein and IL-1 family concentration in bronchoalveolar lavage fluid (BALF) or plasma, and histopathology in cohorts of wildtype, whole body genetically ablated caspase-11 (caspase-11-/-), caspase-1/caspase-11 double knockout (caspase-1/11-/-), gasdermin D (GSDMD-/-), and NLRP3-/- mice. Results: Non-injurious MTV exacerbated mild Poly(I:C) lung injury including disruption of alveolar-capillary barrier and increased levels of IL-6, HMGB1, IL-1β in BALF and IL-18 in plasma. Combined (Poly(I:C)-MTV) injury was associated with increase in gastrointestinal permeability and endotoxin in plasma and BALF. Poly(I:C)-MTV injury was sensitive to caspase-11 deletion with no further contribution of caspase-1 except for maturation and release of IL-18 (that itself was sensitive to deletion of NLRP3). Combined injury led to large increases in pro-caspase-11 and its cleaved product as well as cleaved product of caspase-1. Genetic ablation of GSDMD attenuated alveolar-capillary disruption and maturation and release of cytokines in combined injury model.Conclusions: The previously noted TLR-4 independent exacerbation of mild Poly(I:C)-induced ALI by otherwise non-injurious MTV is associated with an increase in gut permeability resulting in systemic endotoxemia. The gut-lung axis resulted in activation of pulmonary non-canonical (cytosolic mediated caspase-11 activation) and canonical (caspase-1) inflammasome (NLRP3) mediated ALI in this two hit model resulting in GSDMD sensitive alveolar capillary barrier disruption, pyroptosis (in alveolar macrophages) and cytokine maturation and release (IL-1β; IL-18). Pharmacologic strategies at disrupting communication between gut and lung, inhibition of inflammasomes or effector molecule (GSDMD) in pyroptosis may be useful in ALI.
The Analysis of The Application and Mechanism of Traditional Chinese Medicine in Osteoarthritis Based on Data Mining and Network Pharmacology
Authors: YANG Jie , JIAO Dijin , Zhang Guoguang , LIU Juntong , QU Chao , CHEN Hongxu , CHEN Chongmin , SUN Yu 
Published: December 2020

Abstract
Background: Using Data Mining to retrieve the core drug of osteoarthritis in clinic, predicting the drug molecular action target through the Network Pharmacology, combining with the related targets of osteoarthritis to identify the key nodes of the interaction, exploring the pharmacological mechanism of Traditional Chinese Medicine against osteoarthritis and other possible mechanisms of actions. Methods: Pubmed, CNKI, VIP, CBM and WanFang Database was used to retrieve the commonly used therapeutic formulations for osteoarthritis patients in clinical, and screen out the core drugs through the Ancient and Modern Medical Case Cloud Platform and software Gephi, filtered out the core drug molecules and targets combined with TCMSP database and the targets of osteoarthritis in Genecard, OMIM database, impoting those datas into R project and Cytoscape to construct the intersection model of Drug molecule-osteoarthritis, carrying out PPI network and GO and KEGG enrichment analysis with String database. Vina molecular docking was implemented to draw molecular docking diagram, and the results were analyzed after comprehensive analysis. Results: The core drug pairs were identified as "Eucommiae Cortex - Achyranthis Bidentatae Radix" through correlation analysis, complex network analysis basing on the coefficient. "Eucommiae Cortex - Achyranthis Bidentatae Radix" can intervene cell behaviors through multiple pathways and regulate cell metabolism, cytokine synthesis, oxidative , cellular immunity as a consequence of topology analysis in String Database. Conclusions: "Eucommia bark - achyranthes" drug molecules can be combined with the target to produce hydrogen bond, hydrophobic function and Pi-Pi directly or indirectly affecting the corresponding targets, to participate in the regulation of osteogenesis and osteoclast proliferation, protect the extracellular matrix, inhibition of cell apoptosis and anti-inflammatory for resistance to osteoarthritis, also, providing the basis for interpretation of its action mechanism.
Determinants of health facility utilization during childbirth among 15 to 49-year-old women in Uganda: evidence from the Uganda demographic health survey 2016
Authors: Sserwanja Quraish , Mukunya David , Musaba Milton , Kawuki Joseph , Kitutu Freddy Eric 
Published: December 2020

Abstract
BackgroundAlmost all maternal deaths and other related morbidities occur in low income countries. Childbirth supervised by a skilled provider in a health facility is a key intervention to prevent maternal and perinatal morbidity and mortality. Our study aimed to establish the determinants of health facility utilization during childbirth in Uganda. MethodsWe used Uganda Demographic and Health Survey (UDHS) 2016 data of 10,152 women aged 15 to 49 years. Multistage stratified sampling was used to select study participants and we conducted multivariable logistic regression to establish the determinants of health facility utilization during childbirth. All our analyses were done using SPSS version 25. ResultsThe proportion of women who gave birth from a health facility was 76.6% (7,780/10,152: (95% CI: 75.8-77.5). Odds of health facility birth decreased with older age. Women aged 15-19 years were twice as likely to give birth from health facilities compared to women aged 40 to 49 years (AOR=2.25; 95% CI: 1.71- 2.96). Women residing in urban areas were more likely to give birth from a health facility compared to those in rural areas (AOR=1.48; 95% CI: 1.18- 1.86), as well as those who attended ANC (AOR=3.60; 95% CI: 2.47- 5.24). Women in the Northern region were more likely to use health facilities compared to those in the Central region (AOR=2.42; 95% CI: 1.81- 3.22). Odds of health facility birth increased with rise in wealth index and education level. Women with higher education (AOR=5.15; 95% CI: 2.79- 9.52) and those in the richest wealth index (AOR=5.14; 95% CI: 3.72- 7.10) were five times more likely to give birth from a health facility compared to those with no education and those in the poorest wealth index respectively. ConclusionHealth facility utilization during childbirth was high and positively associated with; decreasing age, increasing level of education and wealth index, urban residence, Northern region and ANC attendance. We recommended that interventions to promote health facility childbirths in Uganda should target the poor, less educated and older women especially those residing in rural areas.
Physical Properties of PVDF-GO/Black-TiO2 Nanofibers and its Photocatalytic Degradation of Methylene Blue and Malachite Green Dyes
Authors: Abdelmaksoud M K , Mohamed Alaa , Sayed Abderrahman , Khairy S A 
Published: December 2020

Abstract
BackgroundBlack TiO2 and Graphene Oxide (GO) have attracted intensive attention as an effective catalyst on visible light driven for photodegrading of dyes. In this study, nano-black TiO2 was prepared by a simple hydrogenation of the anatase titanium oxide and the graphene oxide was prepared by applying the modified Hummers method. The prepared powders and nanofiber membranes are carefully examined to ensure their single phase and compound structure formation as well as to measure the equivalent crystallite size and particle distributions. ResultsThe optimum degradation efficiency of malachite green and methylene blue dyes occurred at pH values of 8 and 10, respectively. Afterwards, at the optimum pH value of 8, for malachite green, the degradation efficiency is peaked at 20 mg of the nano-black TiO2 concentration. Then, a comparison of the degradation efficiency of the two mentioned dyes are performed as the fore-mentioned nanofibers are loaded with 20 mg nano-black TiO2 at the corresponding optimum pH vales. ConclusionsThe diffuse reflectance spectroscopy has been investigated to find out the optical energy gaps of the treated and nano-black samples. Finally, a schematic of the redox reaction mechanism has been proposed.
Age-Adjusted Charlson Comorbidity Index in Recurrent Glioblastoma: A New Prognostic Factor?
Authors: Barz Melanie , Bette Stefanie , Janssen Insa , Aftahy A. Kaywan , Huber Thomas , Liesche-Starnecker Friederike , Ryang Yu-Mi , Wiestler Benedikt , Combs Stephanie E. , Meyer Bernhard , Gempt Jens 
Published: December 2020

Abstract
Backround: For recurrent glioblastoma (GB) patients, several therapy options have been established over the last years such as more aggressive surgery, re-irradiation or chemotherapy. Age and the Karnofsky Performance Status Scale (KPSS) are used to make decisions for these patients as these are established as prognostic factors in the initial diagnosis of GB. This study’s aim was to evaluate preoperative patient comorbidities by using the age-adjusted Charlson Comorbidity Index (ACCI) as a prognostic factor for recurrent GB patients.Methods: In this retrospective analysis we could include 133 patients with surgery for primary recurrence of GB from January 2007 until December 2016 (49 females, 84 males, mean age 58 years (range 21–80 years)). Preoperative age, sex, ACCI, KPSS and adjuvant treatment regimes were recorded for each patient. Extent of resection (EOR) was recorded as a complete/incomplete (including biopsy) resection of the contrast-enhancing tumor part.Results: Median overall survival (OS) after initial diagnosis was 20.0 months (95% confidence interval (CI) 17.2-22.9)) and 9.0 months (95% CI 7.1-10.9 months) after first re-resection. Preoperative KPSS > 80% (P<0.001) and ACCI <7 (P=0.020) were associated with significantly improved survival in univariate analysis. Including these preoperative factors in multivariate analysis, preoperative KPSS (≥80/<80) is the only significant prognostic factor (HR 1.934[1.3-3.0], P=0.003), whereas ACCI (<7/≥7) missed statistical significance (HR 1.608[0.8-3.1], P=0.154). Conclusion: ACCI might be an additional prognostic factor for patients with recurrent glioblastoma, especially in those with many comorbidities. However, besides the well-established KPSS, the ACCI does not add further information about patients’ prognosis.
Mental Health Support for COVID-19; A Retrospective Report on the Psychosocial Response Strategy in Lagos, Nigeria
Authors: Oshodi Yewande , Umeh Charles , Sokunbi Modupe , Ajomale Tolu , Fadipe Babatunde , Ajirotutu Omotayo , Kajero Jaiyeola , Fashanu Chizoba , Nyamali Oluyemisi , Coker Olurotimi , Akinyosoye Mofeyisope , Ejiegbu Anne , Adeoye Adefemi , Babalola Gbonjubola , Abiodun Adejoke , Olusanya Oluwatoyin , Chiadika Chris , Owolabi Israel , Ekperechukwu Chigozie , Samuel Aduragbemi , Lebimoyo Azizat , Oyatokun Bolutife , Abdur-Razzak Hussein , Anibaba Moyosore , Saka Babatunde , Adebayo Bisola , Abdus-Salam Ismael , Ogboye Olusegun , Bode Christopher , Osibogun Akin , Abayomi Akin 
Published: December 2020

Abstract
Background : The COVID-19 pandemic has been described to have significant effects on the mental health and emotional well-being of people all over the world generally. This study aimed at describing the set up and functions of the psychosocial support service for the COVID-19 response in Lagos South West Nigeria.Methods: A retrospective and descriptive overview of the psychosocial support for covid-19 patients supported in Lagos, Nigeria over a four-month period. Remote interventions given included Psychological first aid, counselling, psycho pharmacology, and virtual support group sessions. Results: The Psychosocial care provided was a part of the Covid-19 outbreak response strategy in Lagos State, Nigeria. Over 43,000 support calls were made to Covid-19 positive persons; 1,316 hospitalised patients were supported remotely during isolation and more than half declined admission, opting to self-isolate at home instead. Psychosocial home care support group sessions and discharge support groups held. Liaison with all other thematic pillars of the response was key. Conclusion: A comprehensive multidisciplinary mental health and psychosocial support service is an integral part of the management strategy during the pandemic response. The Psychosocial support by the Lagos Covid-19 response presents a practical reproducible approach.
Examining the Effection of Second-and Third-trimester Rate of Gestational Weight Gain on Perinatal Outcomes Among Chinese Twin Gestations Based on the Provisional Guidelines: A Retrospective Cohort Study
Authors: Lin Li-hua , Weng Yi-lin , Lin Ying-ying , Huang Xiu-xian , Lin Yang , Xiu Xiao-yan , Lin Juan , Yan Jianying 
Published: December 2020

Abstract
Background: This paper investigated how second and third trimester gestational weight gain relates toperinatal outcomes among normal weight women with twin pregnancies in Fujian, China. Methods: A retrospective study on the medical records of 931 normal weight twin pregant women was conducted in Fujian Maternity and Child Health Hospital from 2014 to 2018.The 2nd and 3rd trimester weekly weight gain rate were calculated and categorized women as gaining below, within, or above the 2009 Institute of Medicine (IOM) recommended rates . The association between trimester-specific weight gain rate and perinatal outcome was performed by traditional regression analysis among groups.Results:A total of 931 pregnant women and 1862 neonates were included for analysis. 25.9% ,19.8% and 54.3%% of women had less than, greater than and within the recommended rates of gain in the 2nd and 3rd trimester, respectively. Multivariate Logistic regression analysis showed that greater than recommended rates of weight gain in 2nd trimester decreased the risks of preeclampsia (adjusted OR:0.458,95% CI:0.255~0.824). Less than recommended rates of weight gain in 3rd trimester increased the risk of premature delivery（adjusted OR=1.926,95%CI:1.403~2.644）, gestational diabetes mellitus (adjusted OR = 2.052,95%CI:1.417~2.972), intrahepatic cholestasis syndrome (adjusted OR = 3.016,95%CI:1.057~8.606), premature rupture of the membrane (adjusted OR = 1.722,95%CI:1.180~2.512) and neonatal respiratory distress syndrome (adjusted OR = 5.135,95%CI:1.701~15.498) and decreased the risk of cesarean section (adjusted OR = 0.587,95%CI:0.385~0.893) .In addition, greater than recommended rates of weight gain in 3rd trimester was associated with increased risks in premature delivery (adjusted OR=1.818,95%CI:1.307~2.527), and gestational hypertension (adjusted OR=2.098,95%CI:1.018~4.324) as well as preeclampsia(adjusted OR:2.029, 95%CI:1.331~3.093). The stratified analysis of weight gain in 3rd trimester showed that there was no significant difference in the incidence of adverse pregnancy outcomes compared to weight gain rate groups in 2nd trimester.Conclusions: While this study showed gestational weight gain rate less than or greater than in 3rd trimester were associated with some adverse maternal and neonatal outcomes, further studies of prospective and multi-center researches are required to explore alternate ranges of gestational weight gain rate in twin pregnancies.
Facilitating Better Postnatal Care with Women-Held Documents in The Gambia: A Mixed-Methods Study
Authors: Gooden Tiffany , Gustafsson Lotta , Lu Fides , Rickard Faith , Sitch Alice , Cummins Carole , Manneh Kebba , Wilson Amie , MacArthur Christine , Manaseki-Holland Semira 
Published: December 2020

Abstract
Background: Women-held documents are a basic component of continuity of maternity care. The use and completion of women-held documents following discharge could improve treatment and care for postnatal women. Using a mixed-methods study design, we aimed to assess content, quality and completeness of women-held discharge documents and identify factors contributing to the effective use and handover of these documents.Methods: Documents given to women at discharge from all three hospitals in the Greater Banjul Area, The Gambia, were reviewed for content and quality. Poisson regression was used to estimate factors predicting completion of the documents. Semi-structured interviews (n=21) and two focus groups were carried out with healthcare professionals (HCPs).Results: From the 212 women included in the study, nearly all (n=211; 99%) were given a document to take home. The maternal record was the most common (n=207; 98%) and the most complete (17/26 items completed on average; 65%). None of the women’s sociodemographic or clinical characteristics were associated with the completeness of the documents. Themes identified from the interviews include HCPs completing and handing over the documents to women and the ability of women to understand and use the documents. Facilitators and barriers identified from both themes were synthesised alongside the quantitative results. Conclusions: The government-issued maternal record is well established in The Gambia and has potential to be more effective. We recommend a national protocol be established to improve consistent completion and use of the maternal record and to reduce the number of documents HCPs must complete. Training and monitoring of HCPs would ensure the document is complete, given to all women and explained to the women clearly and thoroughly.
Investigation on Prevalence&nbsp;of Sparganum mansoni Infection in Wild Frogs on&nbsp;Hainan Island of China
Authors: Fu Ruijia , Liang Pei , LU Gang , Gu Jinbao , Wang Dayong 
Published: December 2020

Abstract
Background: Sparganosis is a serious food-borne parasitic zoonosis, which is mainly caused by ingesting or open-wound contact of the frog flesh infected by Sparganum mansoni, or even by intake of the water contaminated by the parasite. The purpose of the study was to explore the prevalence of sparganum infection in wild frogs distributed throughout the Hainan Island, which is the largest island of the mainland of China and located at the northwest of the South China Sea, and to analyze the risk in local populations to suffer from sparganosis.Methods: From 2018 to 2020, wild frogs were collected from rural ponds, rivers and farmlands in different cities and counties throughout the Hainan Island. After weighing and marking of the frogs, the sparganums were examined and isolated. The sites of the parasite and the number of infections of each frog were recorded and analyzed by statistics analysis.Results: A total of 1556 of wild frogs were examined and isolated. 201 wild frogs were found to be infected by sparganum, and the natural infection rate of sparganum in wild frogs was 12.92% (201/1556). There were 612 sparganums found in the frogs, and the average was 3.04 per frog, while the highest infection rate of wild frogs was in Baoting, up to 32.93% (27/82). The infection rate of sparganum in wild frogs in the central region of Hainan Island is higher than other regions. Most sparganums were located in the hind legs of frog, and the number of the sparganum infection in the frogs was not related to the species and weight of the frogs.Conclusions: On Hainan Island, sparganum infection in wild frogs is relatively common, and constitutes a potential threat to human. Effective measures should be taken to control the incidence of sparganosis.