bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of post-disaster evacuation on incidence of hyperuricemia in residents of Fukushima Prefecture: the Fukushima Health Management Survey
Authors: Hashimoto Shigeatsu , Nagai Masato , Ohira Tetsuya , Fukuma Shingo , Hosoya Mitsuaki , Yasumura Seiji , Satoh Hiroaki , Suzuki Hitoshi , Sakai Akira , Ohtsuru Akira , Kawasaki Yukihiko , Takahashi Atsushi , Okazaki Kanako , Kobashi Gen , Kamiya Kenji , Yamashita Shunichi , Fukuhara Shun-ichi , Ohto Hitoshi ,   the Fukushima Health Management Survey Group, Ohto Hitoshi , Abe Masafumi , Yamashita Shunichi , Kamiya Kenii , Yasumura Seiji , Hosoya Mitsuaki , Ohtsuru Akira , Sakai Akira , Suzuki Shinichi , Yabe Hirooki , Maeda Masaharu , Matsui Shirou , Fujimori Keiya , Ishikawa Tetsuo , Ohira Tetsuya , Watanabe Tsuyoshi , Satoh Hiroaki , Suzuki Hitoshi , Kawasaki Yukihiko , Takahashi Atsushi , Ozasa Kotaro , Kobashi Gen , Hashimoto Shigeatsu , Suzuki Satoru , Fukushima Toshihiko , Midorikawa Sanae , Shimura Hiromi , Mashiko Hirofumi , Goto Aya , Nollet Kenneth Eric , Niwa Shinichi , Takahashi Hideto , Shibata Yoshisada 
Published: July 2020

Abstract
Aim
After the Great East Japan Earthquake, over 160,000 residents in Fukushima Prefecture were forced to evacuate the area around the Fukushima Daiichi power plant following nuclear accident there. Health problems in these evacuees have since become a major issue. We have examined the association between evacuation and incidence of hyperuricemia among residents in Fukushima.

Methods
We conducted a cohort study of residents aged 40–90 years without hyperuricemia at the time of the Fukushima disaster. Among 8173 residents who met the inclusion criteria before the disaster, 4789 residents (men: 1971, women: 2818; follow-up duration: 1.38 years; and follow-up rate: 58.6%) remained available for follow-up examinations at the end of March 2013. The main endpoint was incidence of hyperuricemia, defined by the Japanese committee guidelines, using local health data from before and after the disaster. We divided participants by evacuation status and compared outcomes between groups. Using a logistic regression model, we estimated the odds ratio for incidence of hyperuricemia, adjusting for potential confounders, age, gender, waist circumference, physical activity, and alcohol consumption.

Results
Incidence of hyperuricemia was higher in evacuees (men 10.1%; women 1.1%) than in non-evacuees (men 7.4%, women 1.0%). Evacuees had higher body mass index, waist circumference, triglycerides, LDL-cholesterol, fasting plasma glucose, HbA1c, and lower HDL-cholesterol after the disaster than non-evacuees. We found that evacuation was associated with incidence of hyperuricemia (adjusted odds ratio: 1.38; 95% confidence interval: 1.03–1.86).

Conclusion
This is the first study to demonstrate an association between evacuation after a disaster and increased incidence of hyperuricemia.
A dynamical system approach for detection and reaction to human guidance in physical human–robot interaction
Authors: Khoramshahi Mahdi , Billard Aude 
Published: July 2020

AbstractA seamless interaction requires two robotic behaviors: the leader role where the robot rejects the external perturbations and focuses on the autonomous execution of the task, and the follower role where the robot ignores the task and complies with human intentional forces. The goal of this work is to provide (1) a unified robotic architecture to produce these two roles, and (2) a human-guidance detection algorithm to switch across the two roles. In the absence of human-guidance, the robot performs its task autonomously and upon detection of such guidances the robot passively follows the human motions. We employ dynamical systems to generate task-specific motion and admittance control to generate reactive motions toward the human-guidance. This structure enables the robot to reject undesirable perturbations, track the motions precisely, react to human-guidance by providing proper compliant behavior, and re-plan the motion reactively. We provide analytical investigation of our method in terms of tracking and compliant behavior. Finally, we evaluate our method experimentally using a 6-DoF manipulator.
Lipid composition of the cancer cell membrane
Authors: Szlasa Wojciech , Zendran Iga , Zalesińska Aleksandra , Tarek Mounir , Kulbacka Julita 
Published: July 2020

AbstractCancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.
Optimization-based decision-making models for disaster recovery and reconstruction planning of transportation networks
Authors: Zamanifar Milad , Hartmann Timo 
Published: July 2020

AbstractThe purpose of this study is to analyze optimization-based decision-making models for the problem of Disaster Recovery Planning of Transportation Networks (DRPTN). In the past three decades, seminal optimization problems have been structured and solved for the critical and sensitive problem of DRPTN. The extent of our knowledge on the practicality of the methods and performance of results is however limited. To evaluate the applicability of those context-sensitive models in real-world situations, there is a need to examine the conceptual and technical structure behind the existing body of work. To this end, this paper performs a systematic search targeting DRPTN publications. Thereafter, we review the identified literature based on the four phases of the optimization-based decision-making modeling process as problem definition, problem formulation, problem-solving, and model validation. Then, through content analysis and descriptive statistics, we investigate the methodology of studies within each of these phases. Eventually, we detect and discuss four research improvement areas as [1] developing conceptual or systematic decision support in the selection of decision attributes and problem structuring, [2] integrating recovery problems with traffic management models, [3] avoiding uncertainty due to the type of solving algorithms, and [4] reducing subjectivity in the validation process of disaster recovery models. Finally, we provide suggestions as well as possible directions for future research.
Application of life-cycle assessment to the eco-design of LED lighting products
Authors: Wang Shuyi , Su Daizhong , Wu You , Chai Zijian 
Published: July 2020

AbstractAn approach for integrating life-cycle assessment (LCA) into the eco-design of lighting products was developed, and LCAs of five lighting products that are currently on the market were then carried out using this approach. Based on the results of these LCAs, the sustainability requests for lighting products were derived and embedded into the product design specification (PDS), thus ensuring that any product developed according to the PDS would have the desired eco-design features. A new sustainable lighting product was then designed according to the PDS and manufactured, after which the new product underwent LCA. Upon comparing the results of the LCA of the new product with the LCA results for the existing lighting products, the newly designed product was found to provide better environmental performance than the existing products (a 27–58% reduction in environmental impact).
The significance of highlighting the oestrogen receptor low category in breast cancer
Authors: Poon Ivan K. , Tsang Julia Y. , Li Joshua , Chan Siu-Ki , Shea Ka-Ho , Tse Gary M. 
Published: July 2020

AbstractThe latest ASCO/CAP guideline has recommended to report oestrogen receptor (ER) low cases (ERlo; 1–10%) as “ER low positive category”, prompting us to compare the clinicopathologic features, biomarkers, survival and treatment of the ERlo cases with other subgroups (ER negative (ERneg) and ER high (ERhi)). ERlo cases revealed more similar clinicopathologic and biomarker profiles (including younger age, larger tumour, high proliferation, HER2 and basal markers expression) to ERneg than ERhi cancers. The ERlo cases receiving hormonal therapy showed a similarly poor outcome as ERneg cancers. However, majority of ERlo cases were downstaged to stage I in the 8th AJCC pathological prognostic staging, highlighting a risk of potential under treatment. Overall, our data highlighted the differences of ERlo from other ERpos cases and their management should be considered separately.
Tunable spin textures in polar antiferromagnetic hybrid organic–inorganic perovskites by electric and magnetic fields
Authors: Lou Feng , Gu Teng , Ji Junyi , Feng Junsheng , Xiang Hongjun , Stroppa Alessandro 
Published: July 2020

AbstractThe hybrid organic–inorganic perovskites (HOIPs) have attracted much attention for their potential applications as novel optoelectronic devices. Remarkably, the Rashba band splitting, together with specific spin orientations in k-space (i.e., spin texture), has been found to be relevant for the optoelectronic performances. In this work, by using first-principles calculations and symmetry analysis, we study the electric polarization, magnetism, and spin texture properties of the antiferromagnetic (AFM) ferroelectric HOIP TMCM-MnCl3 (TMCM = (CH3)3NCH2Cl+, trimethylchloromethyl ammonium). This recently synthesized compound is a prototype of order–disorder and displacement-type ferroelectric with a large piezoelectric response, high ferroelectric transition temperature, and excellent photoluminescence properties as reported by You (Science 357:306, 2017). The most interesting result is that the inversion symmetry breaking coupled to the spin–orbit coupling gives rise to a Rashba-like band splitting and a related robust persistent spin texture (PST) and/or typical spiral spin texture, which can be manipulated by tuning the ferroelectric or, surprisingly, also by the AFM order parameter. The tunability of spin texture upon switching of AFM order parameter is largely unexplored and our findings not only provide a platform to understand the physics of AFM spin texture but also support the AFM HOIP ferroelectrics as a promising class of optoelectronic materials.
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer
Authors: Mastrogamvraki Natalia , Zaravinos Apostolos 
Published: July 2020

AbstractThe deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and spot the major hub proteins within these networks. We reanalyzed 19 GEO gene expression profiles to identify and annotate CRC versus normal signatures, single-gene perturbation, and single-drug perturbation signatures. We identified the co-DEGs across different studies, their upstream regulating kinases and transcription factors (TFs). Connectivity Map was used to identify likely repurposing drugs against CRC within each group. The functional changes of the co-upregulated genes in the first category were mainly associated with negative regulation of transforming growth factor β production and glomerular epithelial cell differentiation; whereas the co-downregulated genes were enriched in cotranslational protein targeting to the membrane. We identified 17 hub proteins across the co-upregulated genes and 18 hub proteins across the co-downregulated genes, composed of well-known TFs (MYC, TCF3, PML) and kinases (CSNK2A1, CDK1/4, MAPK14), and validated most of them using GEPIA2 and HPA, but also through two signature gene lists composed of the co-up and co-downregulated genes. We further identified a list of repurposing drugs that can potentially target the co-DEGs in CRC, including camptothecin, neostigmine bromide, emetine, remoxipride, cephaeline, thioridazine, and omeprazole. Similar analyses were performed in the co-DEG signatures in single-gene or drug perturbation experiments in CRC. MYC, PML, CDKs, CSNK2A1, and MAPKs were common hub proteins among all studies. Overall, we identified the critical genes in CRC and we propose repurposing drugs that could be used against them.
Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson
Authors: Hosoda Yoshikatsu , Miyake Masahiro , Meguro Akira , Tabara Yasuharu , Iwai Sachiko , Ueda-Arakawa Naoko , Nakano Eri , Mori Yuki , Yoshikawa Munemitsu , Nakanishi Hideo , Khor Chiea-Chuen , Saw Seang-Mei , Yamada Ryo , Matsuda Fumihiko , Cheng Ching-Yu , Mizuki Nobuhisa , Tsujikawa Akitaka , Yamashiro Kenji ,   The Nagahama Study Group, Tabara Yasuharu , Kawaguchi Takahisa , Setoh Kazuya , Matsuda Fumihiko , Takahashi Yoshimitsu , Nakayama Takeo , Kosugi Shinji 
Published: July 2020

AbstractKeratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.32 × 10−13), and confirmed a significant association between STON2 rs2371597 and keratoconus development (P = 0.041). Additionally, strong STON2 expression was observed in mouse corneal epithelial basal cells. We also identified SMAD3 rs12913547 as a susceptibility locus for keratoconus development using predictive analysis with IBM’s Watson question answering computer system (P = 0.001). Further GWAS analyses combined with Watson could effectively reveal detailed pathways underlying keratoconus development.
Genetics of Chronic Traumatic Encephalopathy
Authors: Abdolmohammadi Bobak , Dupre Alicia , Evers Laney , Mez Jesse 
Published: July 2020

AbstractAlthough chronic traumatic encephalopathy (CTE) garners substantial attention in the media and there have been marked scientific advances in the last few years, much remains unclear about the role of genetic risk in CTE. Two athletes with comparable contact-sport exposure may have varying amounts of CTE neuropathology, suggesting that other factors, including genetics, may contribute to CTE risk and severity. In this review, we explore reasons why genetics may be important for CTE, concepts in genetic study design for CTE (including choosing controls, endophenotypes, gene by environment interaction, and epigenetics), implicated genes in CTE (including APOE, MAPT, and TMEM106B), and whether predictive genetic testing for CTE should be considered.
Water Reductive Effect of Lymphaticovenular Anastomosis on Upper-Limb Lymphedema: Bioelectrical Impedance Analysis and Comparison with Lower-Limb Lymphedema
Authors: Yasunaga Yoshichika , Yanagisawa Daisuke , Nakajima Yuta , Mimura Shinei , Kobayashi Miharu , Yuzuriha Shunsuke , Kondoh Shoji 
Published: July 2020

AbstractBackground We previously examined the water reductive effect of lymphaticovenular anastomosis (LVA) using bioelectrical impedance analysis (BIA) measurement on lower-limb lymphedema and revealed mean water volume reduction and edema reduction rate by leg LVA to be 0.86 L and 45.1%, respectively. This study aimed to clarify the water reductive effect of LVA on arm lymphedema and compare its results with those for leg lymphedema.Patients and Methods The efficacy of LVA for unilateral arm lymphedema was evaluated using BIA in a retrospective cohort. Limb circumference and arm body water volume (ABW) of the affected and unaffected arms were measured before and after LVA. Mean water volume reduction (ΔABW) and edema reduction rate by arm LVA were compared with values for leg LVA cited from our previous report as a historical control.Results Nineteen consecutive patients were enrolled. The mean ΔABW and edema reduction rate by BIA were 0.267 L and 46.0%, respectively. The decreasing rate of ABW by BIA was significantly larger than those of the upper extremity lymphedema index and sum of 5 circumferences measurement methods. ΔABW could be predicted by a regression line based on the preoperative water volume difference between affected and unaffected limbs. The mean edema reduction rates for arm and leg LVA were comparable.Conclusion The water reductive effect of LVA on upper-limb lymphedema was demonstrated by BIA assessment. BIA can reflect the effect of LVA more sensitively than conventional objective measurements and may facilitate the interpretation of LVA results. Although water volume reduction by arm LVA was less than that by leg LVA, the edema reduction rates were comparable.
Goniometric Evaluation and Passive Range of Joint Motion in Chondrodystrophic and Non-Chondrodystrophic Dogs of Different Sizes
Authors: Reusing Mhayara , Brocardo Mayara , Weber Saulo , Villanova José 
Published: July 2020

Abstract
Objective This study aimed to evaluate angle values in maximal flexion and extension; the passive range of motion (PROM) of the shoulder, elbow, carpal, hip, stifle and tarsus; and the carpal abduction and adduction of chondrodystrophic (CD) and non-chondrodystrophic (NCD) dogs of different sizes.
Study Design Goniometric evaluation was performed in triplicate using a universal goniometer. CD dogs were categorized into miniature, small, medium, large and giant sizes, whereas NCD dogs were allocated to small- and medium-size groups. Hence, each of the seven subgroups comprised 11 clinically healthy dogs. For data analysis, the Levene test was used to evaluate homoscedasticity. The means of each joint angle with the means in each group as well as the PROM between the CD and NCD groups was compared by the Student's t-test; meanwhile, the means of the joint angles and ROM among the sizes were compared by analysis of variance, followed by the Tukey test. In those cases, when no homogeneity variance was observed, the Bonferroni test was used. In every case, p ≤ 0.05 was considered significant.
Results The articular angles and PROM differed according to the dog size and type, that is, CD or NCD.
Conclusion The goniometric values and PROM of dogs depend on the joint type, dog size and chondrodystrophy status. Further studies are necessary to increase the accuracy of the results and to establish the predominant factors governing the differences discovered.
Historical High Complexity Neurosurgery Development of One of the Poorest Brazilian Regions
Authors: Ramos Silvio Pereira , Godoi Bruno Bastos , Cordeiro Patrício Jesus , Neto Jorge Diniz , Gusmão Sebastião Nataniel Silva 
Published: July 2020

AbstractHuman development rates in the Vale do Jequitinhonha, state of Minas Gerais, Brazil, called “Misery Valley,” are among the lowest in the country, not to mention the often precarious psychosocial realities that daily contact with these families reveals. The history of neurosurgery at the Neurosurgical Reference Center at the Vale do Jequitinhonha e Mucuri dates from 2004, when the first neurosurgical procedures were performed in the recently organized Section of Neurosurgery. The historical surgical series shows the positive impact of the service. In 2007, the average was 3 neurosurgeries/month. In the last year, 2018, service growth boosted the record to 34.83 neurosurgeries/month. In addition to performing elective surgery, the neurosurgery team supports the emergency team by performing some neurosurgical procedures. The service number of patients operated since the development of the service is nearly 3,000. Neurosurgery at the Santa Casa de Caridade from Diamantina has been made comparable to the best national neurosurgery services.
Consensus of the Brazilian Association of Nutrology on Milky Feeding of Children Aged 1–5 Years Old
Authors: Nogueira-de-Almeida Carlos Alberto , Falcão Mario Cicero , Ribas-Filho Durval , Zorzo Renato Augusto , Konstantyner Tulio , Ricci Raquel , Gioia Nathalia , Fisberg Mauro 
Published: July 2020

Abstract
Objective To publish a consensus on the milky feeding of children aged between 1 and 5 years old, in the face of the nonuniformity of indication and the lack of standardization, in Brazil, on the nomenclature and classification of milky products produced for this stage.
Methods Literature review and members discussion.
Results The review showed the nutrition deficiencies among Brazilian children and the position of different medical societies.
Conclusions Recommendations of milky feeding are proposed for government area, industry and health care professionals.
Computed Tomography Enhances Diagnostic Accuracy in Challenging Medial Coronoid Disease Cases: An Imaging Study in Dog Breeding Appeal Cases
Authors: Wennemuth Jan , Tellhelm Bernd , Eley Nele , von Pückler Kerstin 
Published: July 2020

AbstractObjectives The aim of this study was to determine the radiographic sensitivity in detecting medial coronoid disease (MCD), using computed tomography (CT) as reference in dogs presented for an official second opinion, and to compare the medial coronoid process (MCP) in fragmented and fissured MCP as well as those unaffected by MCD.Materials and Methods The data of dogs, presented for official second opinion radiographs and CT, were reviewed by three board-certified observers and in accordance with the International Elbow Working Group guidelines regarding MCD. Radiographic delineation, radiopacity and Hounsfield Units (HU) of the MCP were recorded additionally and the correlation between radiography and CT was investigated.Results Sensitivity and specificity of radiography compared with CT yielded values of 83.6% for the former and 83.5% for the latter. False-negative grading in radiography correlated significantly (p = 0.0001) with a present fissure line in CT. The mean delineation (p = 0.03) and mean HU of fragmented MCP (p = 0.0045) were significantly reduced compared with fissured MCP and no significant differences in measured HU for fissured MCP were detected in comparison to elbows unaffected by MCD.Conclusion The results of the present study show substantial agreement between radiography and CT in second opinion cases. However, sensitivity is reduced compared with not preselected cases. A present fissure line in CT was significantly associated with a false-negative grading in radiography. Therefore, CT imaging of the elbows is strongly recommended in cases of appeal.