bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benito Arias Montano
Authors: Kallendorf Hilaire 
Published: September 2020

Benito Arias Montano (b. c. 1525/27–d. 1598) was a Spanish humanist, censor, polymath, and chaplain to King Philip II, as well as librarian for the royal library at El Escorial. He is best known for having produced the Polyglot Bible—also known as the Biblia Regia (Royal Bible)—printed by Christopher Plantin in Antwerp, a monumental undertaking for which it was necessary to move physically to the Netherlands for an extended period of seven years. There he became an agent of international book culture by virtue of his work on the Inquisitorial Index of prohibited and expurgated books, as well as an acquisitions broker for the Spanish royal library and a circle of prominent Spanish intellectuals including Fernando de Herrera and Francisco Pacheco. In addition to printing the Royal Bible, Plantin also received a contract from the Spanish Crown to print other devotional literature (prayer books, breviaries, missals, books of hours, etc.). Arias Montano supervised this publishing program too. The “Rey Prudente” trusted his judgement enough to request his input on important political decisions after he distinguished himself as part of the Spanish delegation to the Council of Trent, the multi-year gathering which launched the Counter-Reformation. Educated in theology at the Universities of Seville and Alcalá, he also became a Knight of the Order of Santiago. He wrote poetry and prose in both Latin and Spanish on a wide range of topics including medicine, geology, physics, architecture, botany, and even painting. His epistolary correspondence with a transnational network of merchants, diplomats and intellectuals is voluminous. In addition to the above-mentioned languages, he was also fluent in Greek, Hebrew, Italian, and French. His probable converso origins might explain some of his activities as a Hebraist, mostly focused around providing a more literal translation of the Bible than the outdated, but still standard, Vulgate.
RADON IN MINES OF KRYVYI RIH IRON ORE BASIN IN UKRAINE
Authors: Molchanov O , Podrezov A , Brechko K , Soroka Y , Ishchenko L 
Published: September 2020

Abstract
The first studies of radiation exposure in old mines of Kryvyi Rih Iron Ore Basin (Kryvbas) began relatively recently, about 20 years ago. The results of these studies have shown that the problem of radon is present in the major part of the Basin mines. In 6 of 8 mines tested, an excess of radiation safety standards for the equilibrium equivalent decay products concentration (EEC) of Radon-222 was observed. According to the sum of the main measured parameters of radiation situation, a preliminary assessment of doses to underground workers was made and a classification of the Basin mines according to radiation danger was developed. Results of the recent radiation surveys of these mines are shown in this article. Data on the incidence of lung cancer among the miners are presented and classified into age groups. Measures to improve the radiation situation in the mines of Kryvbas are considered.
‘Key selection criteria’ as administrative devices: An investigation of academic bureaucratization at Australian universities
Authors: Woelert Peter 
Published: September 2020

AbstractOver recent decades, tensions arising from the ways universities operate have become increasingly apparent. While there have been ongoing ambitions to reduce traditional bureaucratic mechanisms and ‘red tape’ within universities, there has been mounting concern internationally that the administrative dimensions of academic work are becoming increasingly burdensome (a phenomenon also referred to as ‘academic bureaucratization’). This article explores how a specific administrative device used at Australian universities—the ‘key selection criteria’ (KSC) that applicants have to address in writing when applying for academic positions—manifests academic bureaucratization. The analyses of the size, composition, and content of 273 sets of KSC conducted for this article suggest that academic bureaucratization at Australian universities is well entrenched, fueled by the sedimentation of and redundancy in formal elements, and is further reinforced by vacuously-worded requirements reflecting attitudes of indifference, complacency, or cynicism if considering the prospective informational value of applicants’ response.
Minimizing Opioid Overdose Deaths
Authors: Aschenbrenner Diane S. 
Published: September 2020

To help decrease deaths from opioid overdose, the Food and Drug Administration (FDA) is urging health care professionals to discuss naloxone use with patients whenever opioids are prescribed.The FDA is also revising the labeling of all opioid and opioid use disorder medications to include language that encourages coprescription of naloxone.
Cataract surgery contributes to ocular axis growth of aphakic eyes in infants with complex microphthalmos
Authors: Sun Jinfeng , Zhang Jing , Dai Yunhai , Wan Xiaomei , Xie Lixin 
Published: September 2020

Abstract
To observe the ocular axis, visual acuity and intraocular pressure (IOP) of aphakic eye in infants with congenital cataract and complex microphthalmos after first-stage cataract surgery.
This retrospective study included infants with congenital cataract and operated at the Qingdao Eye Hospital between January 2010 and December 2014. The infants were divided into 2 groups: preoperative axial length <18 mm (microphthalmos) or ≥18 mm (controls). Follow-up lasted 24 months; visual acuity, axial length, and IOP were evaluated.
There were 28 infants (55 eyes) in the microphthalmos group and 35 (61 eyes) in the control group. The preoperative visual acuity was negative for optokinetic nystagmus, while the postoperative visual acuity was positive for optokinetic nystagmus in both groups. The growth rate was higher in the microphthalmos group (1.4 ± 0.8 vs 0.8 ± 0.4 mm/yr, P < .001 vs controls). The axial length was smaller in the microphthalmos group at all time points compared with the control group (all P < .001). There was no changes in IOP in the microphthalmos group from baseline to 24 months (P = .147), but the IOP was slightly decreased in the control group (P = .015).
Cataract surgery may contribute to ocular axis growth in infants with complex microphthalmos.
Effectiveness of psychological interventions for treating chronic prostatitis/chronic pelvic pain syndrome
Authors: Xu Yuanjie , Zhang Ling , Shen Yifeng , Yao Hangyu , Yong Shanshan , You Yaodong 
Published: September 2020

AbstractIntroduction:Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, which 50% of men are infected at some point in their lives. Type III CP/CPPS is the most complex and controversial of all types of prostatitis, the highest incidence rate, uncertain efficacy, the long-term treatment that affects the patient's psychopathic symptoms, increases the psychological burden of patients. Psychological intervention for patients with CP/CPPS, which is difficult to treat with drugs and physics, can effectively improve clinical efficacy and improve the psychological condition. The researchers found a high prevalence of psychosocial problems and catastrophic distress in CP/CPPS patients, such as serious mental disorders, especially depression, anxiety and stress, and the high incidence of pain-devastating illness. In this study, we will evaluate psychological interventions as an effective way to relieve chronic prostatitis.Methods and analysis:The databases of English databases (PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library) and Chinese databases (China National Knowledge Infrastructure, China Biology Medicine Database, Wanfang Database, VIP Database) will be retrieved. The search strategy that will be run in the PubMed and tailored to the other database when necessary is presented in this article. RevMan 5.3 and Stata 11.0 will be used for Systematic Review and Meta-analysis. This protocol reported under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and we will report the systematic review by following the PRISMA statement.Results:The study is a protocol for systematic review and meta-analysis without results, and data analysis will be carried out after the protocol. We will share our findings in the third quarter of 2021.Conclusion:This systematic review will provide more evidence to assess whether psychological is an effective intervention for patients with chronic prostatitis/chronic pelvic pain syndrome. Besides, the results will be published in a public issue journal and offer the urologists help to make clinical decisions.Ethics and dissemination:Formal ethical approval is not required in this protocol. We will collect and analyze data based on published research. Since this research does not involve patients, personal privacy will not be affected. The results of this review will be distributed to peer-reviewed journals or submitted to relevant conferences.Protocol registration number:INPLASY202080021
Psychological effect of comprehensive nursing intervention in elderly patients with perforated peptic ulcer
Authors: Chen Bing , Liu Xiu-Yu , Zhang Hong-Mei , Zhang Bai-Jun , Wang Ying-Ting 
Published: September 2020

Abstract

Background:
This study aims to assess the psychological effect of comprehensive nursing intervention (CNI) in elderly patients with perforated peptic ulcer (PPU).

Methods:
This protocol will search all potential studies from inception to the present in electronic database sources (Cochrane Library, PUBMED, EMBASE, PsycINFO, WANGFANG, CBM, and CNKI), and other sources (such as clinical trial registry, and conference proceedings). We will not apply limitations to language and publication status. Two independent authors will scan literature, extract data, and appraise study quality. A third author will be invited to solve any disagreements between 2 authors. We will utilize RevMan 5.3 software for statistical analysis. If necessary, we will also carry out subgroup group, sensitivity analysis, and reporting bias.

Results:
This protocol will summarize high quality evidence to evaluate the psychological effect of CNI in elderly patients with PPU.

Conclusion:
The results of this study may provide evidence to determine whether CNI is effective or not on psychological effect in elderly patients with PPU.

Study registration:
INPLASY202080069.
Association between phonation and the vowel quadrilateral in patients with stroke
Authors: Park Eo Jin , Kim Jae Hoon , Choi Young Hwa , Son Jung Eun , Lee Seung Ah , Yoo Seung Don 
Published: September 2020

Abstract
Articulation disorder is associated with impaired control of respiration and speech organ movement. There are many cases of dysarthria and dysphonia in stroke patients. Dysphonia adversely affects communication and social activities, and it can interfere with everyday life. The purpose of this study is to assess the association between phonation abilities and the vowel quadrilateral in stroke patients.
The subjects were stroke patients with pronunciation and phonation disorders. The resonance frequency was measured for the 4 corner vowels to measure the vowel space area (VSA) and formant centralization ratio (FCR). Phonation ability was evaluated by the Dysphonia Severity Index (DSI) and maximal phonation time (MPT) through acoustic evaluation for each vowel. Pearsons correlation analysis was performed to confirm the association, and multiple linear regression analysis was performed between variables.
The correlation coefficients of VSA and MPT/u/ were 0.420, VSA and MPT/i/ were 0.536, VSA and DSI/u/ were 0.392, VSA and DSI /i/ were 0.364, and FCR and DSI /i/ were −0.448. Multiple linear regression analysis showed that VSA was a factor significantly influencing MPT/u/ (β = 0.420, P = .021, R
2 = 0.147), MPT/i/ (β = 0.536, P = .002, R
2 = 0.262), DSI/u/ (β = 0.564, P = .045, R
2 = 0.256), and DSI/i/ (β = 0.600, P = .03, R
2 = 0.302).
The vowel quadrilateral can be a useful tool for evaluating the phonation function of stroke patients.
Comparative effectiveness of different therapies for treating striae distensae
Authors: Lu Haishan , Guo Jian , Hong Xudong , Chen Aifen , Zhang Xudong , Shen Shengxian 
Published: September 2020

Abstract

Background:
Striae distensae (SD) are common and aesthetically undesirable dermal lesions. The aim of this study is to comprehensively evaluate the effectiveness of different therapies in treating striae distensae using network meta-analysis.

Methods:
A systematic search of electronic databases up to December 1, 2019 was conducted. Randomized controlled trails (RCTs) examining the effectiveness of different methods in treating striae distensae were included. The primary outcomes are clinical effective rate and patient's satisfaction degree. Risk of bias was assessed by the Cochrane risk of bias tool. Network meta-analysis was based on Bayesian framework.

Results:
Fourteen trails that met the criteria with 651 subjects were included. The results of the network meta-analysis show that topical tretinoin combined bipolar radiofrequency showed the highest probability of being the best method to improve the clinical effectiveness and patient satisfaction rate of treating SD (84.5% and 95.7% respectively), closely followed by bipolar radiofrequency (75.3% and 84.3% respectively). Among laser treatment, CO2 fractional laser is superior to other lasers in the clinical effectiveness and patient satisfaction (72.0% and 58.1% respectively). Statistics showed the topical tretinoin was the worst-performing option in improving the clinical effectiveness and patient satisfaction rate of SD treatment (5.4% and 5.1% respectively).

Conclusion:
Based on the results of network meta-analysis, we recommend treating striae distensae with bipolar radio frequency combined topical tretinoin. The commonly used CO2 fractional laser can be considered as alternative treatment candidate. Additional large-scale RCTs are necessary to obtain more precise estimates of their relative efficacy.
Osimertinib induced cardiomyopathy
Authors: Shinomiya Shun , Kaira Kyoichi , Yamaguchi Ou , Ishikawa Keitaro , Kagamu Hiroshi 
Published: September 2020

Abstract

Rationale:
Cardiotoxicity related to osimertinib, including cardiac failure, QT prolongation, and atrial fibrillation, has been reported as an extremely rare incidence in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of osimertinib-induced cardiomyopathy.

Patient concerns:
A 76-year old woman was treated with afatinib (40 mg/day) as the 1st line treatment due to recurrence after surgical resection for pulmonary adenocarcinoma. However, she experienced recurrence with positive T790 M, and osimertinib (80 mg/day) was administered as the 2nd line therapy.

Diagnosis:
Four months after osimertinib initiation, she complained of fever and progressive dyspnea, and a diagnostic endomyocardial biopsy confirmed non-specific cardiomyopathy, indicating osimertinib-induced cardiomyopathy.

Interventions and outcomes:
She was treated with furosemide, carvedilol, and enalapril, and her cardiac function, her symptoms, and condition improved 3 weeks after the withdrawal of osimertinib.

Lessons:
Physicians should be alert of the cardiomyopathy-causing potential of osimertinib in advanced NSCLC patients.
First case of bronchiolar adenoma lined purely by mucinous luminal cells with molecular analysis
Authors: Liu Shuli , Liu Nan , Xiao Mingming , Wang Liang , Wang En-Hua 
Published: September 2020

Abstract

Rationale:
Bronchiolar adenoma (BA) is a newly designated rare entity of the lung, including both the currently designated ciliated muconodular papillary tumor (CMPT) and so-called non-classic CMPT. The most prominent histological feature of BAs is the bilayered cell structures composed of the continuous basal cell layer and the luminal layer which consists of different proportion of mucinous cells, ciliated cells, Clara cells and/or type II pneumocytes. BA purely covered by mucinous cells without other components in the luminal layer has never been reported.

Patient concerns:
An 82-year-old female patient was detected a 0.8 cm ground glass nodule in the left lower lobe of the lung.

Diagnoses:
The serum levels of tumor markers were normal.

Interventions:
The patient underwent a segmentectomy of the left lower lobe.

Outcomes:
The postoperative pathological diagnosis was BA. Molecular analysis revealed that the tumor harbored ALK rearrangement and BRAF mutations simultaneously. There was no recurrence in 17 months of follow-up.

Lessons:
BA can be lined only by mucinous cells, without any cuboidal and/or ciliated cells in the surface layer. This sets a dangerous pitfall in differentiation diagnosis with invasive mucinous adenocarcinoma especially during intraoperative frozen pathological diagnosis.
A novel FGFR2 (S137W) mutation resulting in Apert syndrome
Authors: Shi Qingyang , Dai Rulin , Wang Ruixue , Jing Jili , Yu Xiaowei , Liu Ruizhi , Liu Yanhong 
Published: September 2020

Abstract

Rationale:
Apert syndrome (AS) is an autosomal dominant inheritance pattern of the most severe craniosynostosis syndrome. AS is characterized by synostosis of cranial sutures and acrocephaly, including brachycephaly, midfacial hypoplasia, and syndactyly of the hands and feet. Patients with AS often present with craniosynostosis, severe syndactyly, and skin, skeletal, brain, and visceral abnormalities.

Patient concerns:
A pregnant Chinese woman presented with a fetus at 23 + 5 weeks of gestation with suspected AS in a prenatal ultrasound examination. Following ultrasound, the pregnancy underwent spontaneous abortion. Gene sequencing was performed on the back skin of the dead fetus.

Diagnosis:
The diagnosis of AS was confirmed on the basis of clinical manifestations of the fetus, and a de novo mutation in the fibroblast growth factor receptor 2 (FGFR2) gene was identified.

Interventions:
The couple finally chose to terminate the pregnancy based on the ultrasonic malformations and the risk of the parents having a neonate with AS in the future is small. However, any future pregnancy must be assessed by prenatal diagnosis.

Outcomes:
The dead fetus presented with bilateral skull deformation. Additionally, there were bilateral changes to the temporal bone caused by inwards movement leading to concave morphology, a “clover” sign, and syndactyly from the index finger/second toe to the little finger/little toe. AS was diagnosed by genetic testing, which showed a p.S137W (c.410C>G, chr10:123279677) mutation in the FGFR2 gene.

Lessons:
Clinicians should be aware that there are a variety of ultrasound findings for AS. Therefore, genetic testing should be used when appropriate to confirm diagnosis of AS.
Antiretroviral treatment and its impact on oral health outcomes in 5 to 7 year old Ugandan children
Authors: Birungi Nancy , Fadnes Lars T. , Engebretsen Ingunn M.S. , Tumwine James K. , Åstrøm Anne Nordrehaug 
Published: September 2020

Abstract

Background:
Antiretroviral therapy for HIV in sub-Saharan Africa has transformed the highly infectious virus to a stable chronic condition, with the advent of Highly active antiretroviral therapy (HAART). The longterm effects of HAART on the oral health of children are understudied.

Objective:
To compare the effect of lopinavir-ritonavir and lamivudine on oral health indicators (dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children from the ANRS 12174 trial.

Methods:
This study used data collected in 2017 among children aged 5 to 7 years from the Ugandan site of the ANRS 12174 randomized trial (ClinicalTrials.gov no: NCT00640263) implemented between 2009 and 2012 in Mbale district, Eastern Uganda. The intervention was lopinavir-ritonavir or lamuvudine treatment to prevent vertical HIV-1 transmission. One hundred thirty-seven and 139 children were randomized to receive lopinavir-ritonavir or lamivudine treatment at day 7 postpartum to compare efficacy of prevention of vertical HIV-1 transmission. At follow up, the children underwent oral examination using the World Health Organization methods for field conditions. The oral health related quality of life was assessed using the early childhood oral health impact scale. Negative binomial and logistic regression were used for the analysis of data.

Main outcome measures:
Dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children.

Results:
The prevalence of dental caries was 48% in the study sample: 49% in the lopinavir-ritonavir arm and 48% in the lamivudine treatment group. The corresponding mean decayed missing filled teeth and standard deviation was 1.7 (2.4) and 2.3 (3.7) The mean number (standard deviation) of erupted permanent teeth was 3.8 (3.7) and 4.6 (3.9) teeth in the lopinavir- and lamivudine group, respectively. The prevalence of reported impacts on oral health was 7% in the lopinavir-ritonavir and 18% in the lamivudine group. Gingivitis had a prevalence of 7% in the lopinavir-ritonavir and 14% lamivudine treatment group. The regression analysis revealed 70% less reported impacts on oral health in lopinavir-ritonavir group than the lamivudine treatment group with an incidence rate ratio of 0.3 (95% confidence interval: 0.1–0.9).

Conclusions:
HIV exposed uninfected infants in the lopinavir-ritonavir group reported less impacts on oral health than the lamivudine treatment group. Dental caries, gingivitis, and tooth eruption were not significantly affected by the treatment lopinavir-ritonavir or lamivudine.

Trial Registration ClinicalTrials.gov identifier:
NCT00640263.