bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Responses of Stem Cells to Photobiomodulation Therapy
Authors: Khorsandi Khatereh , Hosseinzadeh Reza , Abrahamse Heidi , Fekrazad Reza 
Published: February 2020

Background:
Stem cells have attracted the researchers interest, due to their applications in
regenerative medicine. Their self-renewal capacity for multipotent differentiation, and immunomodulatory
properties make them unique to significantly contribute to tissue repair and regeneration applications.
Recently, stem cells have shown increased proliferation when irradiated with low-level laser
therapy or Photobiomodulation Therapy (PBMT), which induces the activation of intracellular and
extracellular chromophores and the initiation of cellular signaling. The purpose of this study was to
evaluate this phenomenon in the literature.

Methods:
The literature investigated the articles written in English in four electronic databases of
PubMed, Scopus, Google Scholar and Cochrane up to April 2019. Stem cell was searched by combining
the search keyword of "low-level laser therapy" OR "low power laser therapy" OR "low-intensity
laser therapy" OR "photobiomodulation therapy" OR "photo biostimulation therapy" OR "LED". In
total, 46 articles were eligible for evaluation.

Results:
Studies demonstrated that red to near-infrared light is absorbed by the mitochondrial respiratory
chain. Mitochondria are significant sources of reactive oxygen species (ROS). Mitochondria play
an important role in metabolism, energy generation, and are also involved in mediating the effects
induced by PBMT. PBMT may result in the increased production of (ROS), nitric oxide (NO), adenosine
triphosphate (ATP), and cyclic adenosine monophosphate (cAMP). These changes, in turn, initiate
cell proliferation and induce the signal cascade effect.

Conclusion:
The findings of this review suggest that PBMT-based regenerative medicine could be a
useful tool for future advances in tissue engineering and cell therapy.
Feature Selection Algorithm for High-dimensional Biomedical Data Using Information Gain and Improved Chemical Reaction Optimization
Authors: Zhang Ge , Yu Pan , Wang Jianlin , Yan Chaokun 
Published: February 2020

Background:
There have been rapid developments in various bioinformatics
technologies, which have led to the accumulation of a large amount of biomedical data. However,
these datasets usually involve thousands of features and include much irrelevant or redundant
information, which leads to confusion during diagnosis. Feature selection is a solution that consists
of finding the optimal subset, which is known to be an NP problem because of the large search
space.

Objective:
For the issue, this paper proposes a hybrid feature selection method based on an improved
chemical reaction optimization algorithm (ICRO) and an information gain (IG) approach, which
called IGICRO.

Methods:
IG is adopted to obtain some important features. The neighborhood search mechanism is
combined with ICRO to increase the diversity of the population and improve the capacity of local
search.

Results:
Experimental results of eight public available data sets demonstrate that our proposed
approach outperforms original CRO and other state-of-the-art approaches.
Bias-motivated Victimization of Immigrant Students in Schools: Incidence, Impact, and Intervention
Authors: Daly Brian P. , Puhy Chandler E. , Silverstein Michael J. , Jones Lisa 
Published: February 2020

Background:
Bias-motivated victimization is common among school-age youth
and is associated with negative academic and emotional consequences. Few studies have
looked at the incidence of various forms of bias-motivated victimization for first- and second-
generation immigrant-origin students even though these students represent an especially
vulnerable population for experiencing bias.

Objective:
The present study investigated whether immigrant-origin students reported higher
incidences of bias-motivated victimization relative to their nonimmigrant-origin peers. For
students who experienced bias-motivated victimization, we examined the impact of these experiences
on levels of distress and examined perceived social and community support between
immigrant-origin and nonimmigrant-origin students.

Methods:
Participants completed the Youth Bias Victimization Questionnaire (YBVQ), a
questionnaire designed to capture information about how often youth experience different
types of bias-motivated victimization.

Results:
Approximately 60% of youth in the full sample reported experiencing one or more
types of bias victimization in their lifetime and this rate was generally equivalent across immigrant-
origin and nonimmigrant-origin participants. For those students who reported at
least one lifetime event of bias victimization, immigrant-origin youth were more likely than
nonimmigrant-origin youth to experience victimization related to peers’ perceptions of their
country of origin or immigrant status. There were no significant differences in reported levels
of distress or perceived social and community support between immigrant-origin and
nonimmigrant-origin youth, regardless of whether they experienced bias-motivated victimization
during their lifetime.

Conclusion:
Clinicians working in school settings should be aware of the high incidence of
students who experience bias-motivated victimization and when indicated provide targeted
intervention services to those negatively impacted by these experiences.
Keefektifan metode CIRC, role playing, dan VCT dalam meningkatkan hasil belajar IPS yang komprehensif
Authors: Hutami Trapsila Siwi , Hastuti Hastuti 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui keefektifan metode CIRC, Role Playing dan VCT dalam meningkatkan hasil belajar IPS pada aspek: (1) pengetahuan, (2) sikap, dan (3) keterampilan. Penelitian ini adalah penelitian quasi experiment. Populasi penelitian ini adalah SMP di Kabupaten Bantul yang menerapkan Kurikulum 2013. Sampel penelitian ditentukan dengan teknik purposive random sampling. Pengumpulan data menggunakan tes, lembar penilaian diri, dan tes kinerja dalam bentuk proyek. Pengujian hipotesis dengan teknik One Way Anova pada taraf signifikansi 0,05. Hasil penelitian menunjukkan bahwa: (1) ada perbedaaan keefektifan antara metode CIRC, Role Playing dan VCT dalam meningkatkan hasil belajar IPS pada aspek pengetahuan; (2) ada perbedaaan keefektifan antara metode CIRC, Role Playing dan VCT dalam meningkatkan hasil belajar IPS pada aspek sikap; (3) ada perbedaaan keefektifan antara metode CIRC, Role Playing dan VCT dalam meningkatkan hasil belajar IPS pada aspek keterampilan. Dengan demikian ketiga metode tersebut mempunyai perbedaan keefektifan untuk meningkatkan hasil belajar IPS yang komprehensif. AbstractThis reseacrh aims to determine the effectiveness of CIRC method, Role Playing, and VCT in improving the learning outcomes in social studies in the aspects of: (1) knowledge, (2) attitude, (3) skill. This research is a quasi experiment. The population was the students of a junior high schools in Bantul Regency which have implemented Curriculum 2013. The sample was established using the purposive sampling technique. The data collection used a test, a self esteem sheet, and a test in the form of a project. The hypotesis testing used the One Way Anova technique at the significance level of 0.05. The result of this research shows that: (1) there are some differences in the effectiveness between the CIRC Method, Role Playing, and VCT in improving the learning outcomes in the knowledge aspect of social studies; (2) ) there are some differences in the effectiveness between the CIRC Method, Role Playing, and VCT in improving the learning outcomes in the attitudinal aspect of social studies; (3) there are some differences in the effectiveness between the CIRC Method, Role Playing, and VCT in improving the learning outcomes in the skill aspect of social studies. Therefore, these three methods have the differences in the effectiveness for improving the comprehensive social studies learning outcomes.
Infiltrasi budaya global terhadap budaya lokal pesta Baratan dalam mempengaruhi pembentukan budaya kewargaan
Authors: Ulum Amalia Zidatul , Suharno Suharno 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui bentuk infiltrasi budaya global dalam pesta Baratan serta pengaruhnya terhadap perubahan perilaku sosial masyarakat Jepara. Penelitian menggunakan metode kualitatif deskriptif dengan pendekatan fenomenologi. Subjek penelitian ditentukan dengan teknik purposive sampling. Data penelitian diperoleh melalui wawancara, observasi, dan analisis dokumen dan dianalisis dengan teknik analisis interaktif model Miles dan Huberman. Hasil penelitian menunjukkan budaya global yang masuk melalui pesta Baratan berpengaruh terhadap pembentukan perilaku sosial yang sedang berkembang dalam masyarakat Jepara. AbstractThis study aims to determine the form of global cultural infiltration in the Baratan festival and its influence on social behavior changes in Jepara society. The study conducted with qualitative methods with a phenomenological approach. The research subjects were determined by purposive sampling technique. The research data were obtained through interviews, observations, and document analysis and were analyzed using the interactive analysis technique of the Miles and Huberman models. The results showed that the global culture that entered through the Baratan festival influenced the formation of social behavior that was developing in Jepara society.
Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial
Authors: Merkel Peter A , Jayne David R , Wang Chao , Hillson Jan , Bekker Pirow 
Published: February 2020

Background
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a serious, often life-threatening disease. In new-onset disease or a relapse, the standard treatment is immunosuppressive therapy with glucocorticoids; these therapies are associated with substantial short- and long-term toxicity. Complement component 5a (C5a) binding to C5a receptor (C5aR) may play a central role in the pathogenesis of ANCA-associated vasculitis. Avacopan is a novel, orally bioavailable, and highly selective antagonist of human C5aR. Avacopan does not interfere with the production of C5b or the membrane attack complex (ie, terminal complement complex) and does not block C5a binding to a second receptor, C5L2 (also called C5aR2), shown to be protective in antimyeloperoxidase glomerulonephritis. This trial will evaluate if avacopan replaces the need for chronic glucocorticoids in the treatment of ANCA-associated vasculitis.

Objective
The aim of this study is to determine the proportions of patients in remission at week 26 and with sustained remission at week 52, defined as Birmingham Vasculitis Activity Score=0, and not taking glucocorticoids within the 4 weeks before week 26 and week 52, respectively.

Methods
The Avacopan Development in Vasculitis to Obtain Corticosteroid elimination and Therapeutic Efficacy study is a randomized, double-blind, active-comparator (prednisone), 2-arm study evaluating the safety and efficacy of avacopan versus prednisone, administered in combination with other immunosuppressive therapy. Eligible subjects will have active disease requiring induction of remission. Subjects are stratified based on the type of immunosuppressive therapy, ANCA subtype, and new or relapsing disease. Target sample size is 300 patients, enrolled at over 200 sites globally. All authors and local ethics committees approved the study design. All patients will provide informed consent.

Results
Enrollment of patients was completed in Q4 2018. Topline results are anticipated to be published by Q3 2020.

Conclusions
Results will be released irrespective of whether the findings are positive or negative.

Trial Registration
ClinicalTrials.gov NCT02994927; https://clinicaltrials.gov/ct2/show/NCT02994927

International Registered Report Identifier (IRRID)
DERR1-10.2196/16664
A PHYTOCHEMICAL STUDY ON EUPATORIUM GLANDULOSUM
Authors: SILPA M  , SURESH JOGHEE  , HAMSALAKSHMI  
Published: February 2020

Objective: Eupatorium glandulosum is a useful medicinal plant belongs to the family Asteraceae. It is traditionally used to treat various diseases such as wound healing, antioxidant, and antiproliferative. The present study was aimed to investigate the physicochemical and phytochemical properties of various extracts of aerial parts of E. glandulosum.
Methods: The E. glandulosum plant materials were extracted using the solvents alcohol, ethyl acetate, and chloroform by Soxhlet method. The extracts were screened for physiochemical constants, preliminary phytochemical analysis for carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The quantitative phytochemical analysis was carried out for total flavonoid and total phenols using standard procedures.
Results: The physiochemical constituents such as total ash, acid-insoluble ash, and water-soluble ash were found to be 14.25% (w/w), 5% (w/w), and 7.30% (w/w), respectively. The preliminary phytochemical screening confirmed the presence of carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The flavonoid content of the plant extracts was found to be in the descending order ethyl acetate ˃alcohol ˃chloroform and the phenolic content was found to be alcohol ˃ethyl acetate ˃chloroform.
Conclusion: The result showed the presence of phytochemical constituents and higher values of phenolic and flavonoid content make the plant useful for the formulation of the different drugs for human uses for treating various diseases.
GREEN SYNTHESIS, BIOLOGICAL EVALUATION AND DFT CALCULATIONS OF THIAZOLIDINONE DERIVATIVES – A REVIEW
Authors: ROSY P JACQULINE , JEBASTIN SONIA JAS M  , K SANTHANALAKSHMI , S MUTHUKUMAR 
Published: February 2020

In the new millennium, we have novel biological targets which are defined at the molecular level, which have incredible success in comprehending human illness. On the other hand, the drug design processes are largely including pharmaceutical research study, scientific intuition, reaction and expertise to drive. Final thoughts attracted from this analysis can perform crucial function shaping the way our team believe concerning existing as well as future projects. With its origins rooted in natural synthesis as well as medicinal chemistry, heterocyclic compounds are existed themselves as a fundamental department of organic chemistry. IUPAC defined “cyclic compounds possessing ring members with atoms of at least two distinct elements" 1. Heterocyclic ring structures are core substances made up of components aside from carbon, where one of the most usual substituents is oxygen, nitrogen as well as sulphur 2, 3. According to the heteroatom(s) existing in the ring structure, heterocyclic could be recorded as oxygen, nitrogen or sulfur based and within each and every class of compound is based on the size of the ring structure, determined by the total number of atoms 4. The type and size of the ring structures, as one with the substituent groups of the core scaffold, impact is strongly on the physico-chemical properties 5.
Heating responses with conventional devices, such as oil bath and also home heating mantles, are not only slow, yet additionally it produces a hot surface area on the reaction vessel where reagents, items and substrates are frequently disintegrate after at some time. Microwave power alternatively, is brought right into the chemical reactor from another location and travels through the walls of the response vessel, warming the catalysts and solvents directly. Microwave dielectric heating drives chain reactions by manipulating the benefit of the potential of some solids and liquids to change electromagnetic radiation into warm. Recently, a new technique has actually concerned the leading edge of chemical investigation, that is, microwave dielectric heating. In a similar method to the introduction of the isomantle, this technical advancement will no question need an adjustment in the drug store's mind set. In the future, the drug store will make use of fast blasts of microwave power to heat and also increase chemical reactions, as opposed to an alternate application in the very first circumstances for the mantle or hot plate. High-speed synthesis with microwaves has actually attracted a significant quantity of rate of interest in most recent years 6. Considering that, the very first reports on the usage of microwave home heating by Gedye and also Giguere / Majetich groups in speeding up organic chemical conversion in 1986, far more than 2,000 write-ups have been released in the area of Microwave Assisted Organic Synthesis 7, 8.
ASSOCIATION BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO WITH 1-YEAR MORTALITY IN HEMODIALYSIS PATIENT IN WANGAYA REGIONAL GENERAL HOSPITAL
Authors: I PUTU YOGI SASTRAWAN  , CHRISTINA PERMATA SHALIM  
Published: February 2020

Objective: The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with mortality risk in patients with hemodialysis (HD).
Methods: We conducted a retrospective cohort study among regular HD patients at Wangaya Regional General Hospital. Data were collected from patients’ medical records in June 2018 and followed up until May 2019.
Results: NLR and PLR were significantly associated with 1-year mortality (p=0.047 and p=0.009), with higher NLR (NLR>2.84) and higher PLR (PLR>10) associated with higher risk of 1-year mortality (relative risk [RR]=3.36 and RR=5.19).
Conclusion: NLR and PLR were significantly associated with 1-year mortality in patients with HD.
DESIGN AND SYNTHESIS OF NOVEL 2, 3-DISUBSTITUTED QUINAZOLINES: EVALUATION OF IN VITRO ANTICANCER ACTIVITY AND IN SILICO STUDIES
Authors: BUGGANA SIVA JYOTHI , MANI CHANDRIKA PATURI  , RAJENDRA PRASAD VVS  
Published: February 2020

Objective: In this study, a series of novel 2,3-disubstituted quinazolines (4a-4l) were synthesized using standard procedures and elucidated through different spectroscopic techniques.
Methods: Obtained compounds were evaluated for their cytotoxicity against human breast cancer (MDA-MB-231) and ovarian cancer (SK-O-V3) cell lines using MTT assay. Docking studies with JAK2 protein were performed to elucidate the possible mechanistic insights into these novel quinazoline derivatives.
Results: Moderate-to-good in vitro cytotoxic potentials of the newly synthesized molecules were reported against selected human cancer cell lines. Among the tested molecules, compound 4e showed good cytotoxic activity against MD-AMB-231 (14.2 ± 0.86 μM) and against SK-O-V3 (17.7 ± 0.62 μM).
Conclusion: The in vitro studies of the newly synthesized quinazoline derivatives reported considerable cytotoxic potentials against both breast and ovarian cancer cell lines and SAR studies suggest that quinazoline derivatives with heterocyclic benzothiazole nucleus with hydrophilic acetamide linkage at the 3rd position could probably increase the cytotoxic potentials and the presence of chlorine substitution could add more benefit. With the reported bioactivities of these derivatives, further studies on the derivatization could elucidate the broader cytotoxic potentials.
COMPARATIVE STUDY AGAINST OXIDATIVE STRESS AND DNA DAMAGE PROTECTION ACTIVITY OF THE DIFFERENT EXTRACTS OF TUBERS OF ARISAEMA TORTUOSUM (WALL.) SCHOTT.
Authors: PRIYANKA CHAKRABORTY  , NRIPENDRA NATH BALA  , DAS SUDIPTA 
Published: February 2020

Objective: Our main aim is to evaluate the comparative in vitro antioxidant and DNA damage protection activity study with different extracts of tubers of Arisaema tortuosum.
Methods: A. tortuosum (Wall.) Schott. (Araceae family) is commonly known as whipcord cobra lily, used in India as traditional medicine. In vitro, antioxidant activity was done by six methods including determination of total phenolic and total flavonoid compounds. The DNA damage was estimated by standard diphenylamine reaction.
Results: Methanolic extract of tubers of A. tortuosum has been found rich in phenolic and flavonoid compounds when compared with other extracts. Methanolic extract of rhizomes of A. tortuosum showed potent antioxidant activity at a concentration of 400 μg/mL and potent the DNA damage protecting activity at a concentration of 50 μg/mL.
Conclusion: Comparative study against oxidative damage and protection to the DNA damage protection activity of the different extracts of tubers of A. tortuosum (Wall.) Schott. showed that methanolic extract is most potent, though ethyl acetate extract also showed activity.
LASERTERAPIA COMO COADJUVANTE NO PÓS OPERATÓRIO DE TERCEIROS MOLARES: REVISÃO DE LITERATURA
Authors: Coelho Dias Anna Caroline 
Published: February 2020

RESUMOA laserterapia é um recurso muito utilizado como coadjuvante em cirurgias de terceiros molares no intuito de proporcionar ao paciente benefícios pós-operatórios e um melhor prognóstico clínico. A exodontia de terceiros molares obrigatoriamente envolve injúria aos ossos e tecidos moles. Estudos mostram que o uso do Laser de Baixa Potência (LBP) concede ao organismo uma melhor resposta inflamatória, com consequente redução do edema, diminuição da sintomatologia dolorosa, e bioestimulação celular. A laserterapia não ablativa é atualmente um importante auxiliar nas cirurgias dento-alveolares em geral, trazendo qualidade e rápida cicatrização de tecidos tanto moles quanto duros. Seus efeitos terapêuticos antiálgicos, antiinflamatórios, antiedematosos e cicatrizantes são concebidos devido às características especiais de seu feixe de luz tais como, monocromaticidade, paralelismo e brilho intenso que conferem o processo de bioestimulação, proporcionando ao paciente a otimização do conforto e o bem-estar tão desejado no tratamento odontológico e, principalmente, no pós operatório de exodontias. O objetivo desse trabalho é apresentar uma revisão de literatura sobre o uso do LBP em cirurgias de terceiros molares. Palavras-chave: Laserterapia; exodontia; terceiros molares; cicatrização.
DOR OROFACIAL, DISFUNÇÃO TEMPOROMANDIBULAR E OSTEOPOROSE SENIL: ABORDAGEM ODONTOLÓGICA EM IDOSOS
Authors: Spezzia Sérgio 
Published: February 2020

Resumo Dor orofacial (DOF), consta do conjunto de condições dolorosas provenientes da boca e face, incluindo dor de dente, disfunções temporomandibulares (DTMs), neuralgias, alguns tipos de cefaleias e outros quadros dolorosos. Osteoporose é uma doença osteometabólica caracterizada por perda de massa óssea e deterioração da microarquitetura do tecido ósseo com consequente fragilidade óssea e maior suscetibilidade à fraturas. Pode-se classificar a osteoporose em osteoporose senil e osteoporose pós-menopausa. Algumas alterações sistêmicas, como a osteoporose podem provocar repercussões nas DOF. O objetivo proposto no presente artigo foi evidenciar como a osteoporose senil pode agir a nível da saúde bucal dos indivíduos, afligindo possivelmente a articulação temporomandibular (ATM) dos mesmos, ocasionando DTM, com manifestações nas DOF. Alterações sistêmicas que comprometem outras articulações do corpo podem atingir a ATM, é o que ocorre nos casos da artrite psoriatica, lúpus e na artrite reumatoide. Algumas dessas alterações, tal como a osteoporose podem ter correlação com DOF e DTM e devem ter diagnóstico diferencial e tratamento odontológico diferenciado. O acometimento por osteoporose na ATM pode ter diagnóstico de DTM. Concluiu-se que a osteoporose pode influir nas manifestações clínicas das DOF, sendo fundamental o conhecimento e a conscientização pelo cirurgião dentista dessa doença sistêmica que pode acometer a saúde bucal dos seus pacientes. Palavras-chave: Idoso. Osteoporose. Dor Facial. Palpação. Keywords: Aged. Osteoporosis. Orofacial Pain. Palpation.