bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness and Perceptions of Pharmacy Students Regarding ChatGPT in a sub-Saharan African Country, Zambia: Findings and Implications on the Education System
Authors: Mudenda Steward , Mufwambi Webrod , Mwale Ridge Samson , Kathewera Bernard , Lubanga Adriano Focus 
Published: December 2024

Abstract

Background
Artificial intelligence (AI) has emerged as a powerful tool in many sectors including healthcare education. ChatGPT is a widely used generative AI model among learners and teachers globally. In Zambia, there is no information regarding the use of ChatGPT among healthcare students. Therefore, this study assessed pharmacy students' perceptions of ChatGPT use at the University of Zambia.
Methods
This cross-sectional study was conducted from February 2024 to May 2024 among pharmacy students at the University of Zambia using a structured questionnaire. The questionnaire was based on the validated TAME-ChatGPT survey instrument on the determinants of attitude and usage of ChatGPT among health students. Perception of ChatGPT was assessed using four items grouped into a single variable comprising the primary study measure and dichotomized into “positive” vs. “negative” perceptions.
Results
A total of 385 responses were obtained, with 358 participants (93.0%) who heard of ChatGPT before the study, and 303 used ChatGPT (78.7%). In univariate analyses, the following factors were significantly associated with a positive perception of ChatGPT: low perceived risk (P=.009), low anxiety (P=.010), and a high score on technology/social influence (P<.001), with the latter factor being the only influencing factor in multivariate analysis (aOR: 2.908, 95% CI: 1.752–4.825). Regarding the influencing factors for ChatGPT use, the perceived usefulness was the only significant factor (P=.013).
Conclusions
The study results showed the widespread use of ChatGPT among pharmacy students in Zambia highlighting its increasing role as part of the educational process. To better implement this advanced generative AI tool in healthcare education, academics and universities must take into account the role of social influence and readiness to accept technology as well as emphasizing the role of usefulness to foster the educational process.
«СТАНЕМ ЖЕ ФИННАМИ…»: РЕЦЕПТ СОЗДАНИЯ ФИНСКОЙ НАЦИИ ДЛЯ ЕВРОПЕЙСКОЙ ВЕСНЫ НАРОДОВ
Authors: Лескинен М.В. 
Published: December 2024

Статья посвящена истории праздника студентов Александровского университета в Гельсингфорсе в год Весны народов. День Флоры 13 мая 1848 года стал важным событием на пути формирования финской нации, ее символических воплощений (гимн, флаг, имя) и национальной идентичности финнов. Рассмотрены задачи организаторов праздника – университетских преподавателей-фенноманов, шведов по происхождению и языку, провозглашенных позднее отцами-основателями финской нации.
The article is dedicated to the history of the celebration of Flora’s Day (May 13, 1848), which took place at the Alexandrov’s University in Helsingfors in the year of the Spring of the Nations. This Day is an important event on the way to the formation of the Finnish nation, its symbols (hymn, flag, name Finland) and national identity of the Finns. The organizers of this students’ Flora’s Day became the university professors-Fennomans, Swedes by origin and language, and later all of them were proclaimed as the founders and leaders of the Finnish nation. Their ideas, tasks and history of celebration are under consideration.
ВСЕСОЮЗНЫЙ Х, ИЛИ НОЛЬ С ПАЛОЧКОЙ.(Празднование 10-летия Октября в произведениях Андрея Платонова и проектах трудящихся
Authors: Яблоков Е.А. 
Published: December 2024

Публиковавшиеся в 1927 г. в советских СМИ предложения о формах празднования 10-летия Октября сопоставлены с соответствующими мотивами произведений Андрея Платонова, прежде всего с его сатирическим рассказом «Надлежащие мероприятия». Представленный в платоновском творчестве пародийный образ советской ритуальной практики позволяет более наглядно представить доминировавшие в 1920-х гг. государственные стратегии и тенденции массового сознания.
The article is devoted to the formation of the “October’s revolution” canon. The proposals concerning the celebration the 10th anniversary of October, published in 1927 in the Soviet press, are compared with the corresponding motifs of the works of one of the greatest Russian writers Andrei Platonov, primarily with his satirical story "Proper Measures". The parodic image of Soviet ritual practice presented in Platonov's works makes possible to clarify not only the historical situation of the 1920s, but the dominating state’s strategies and mass consciousness tendencies of that time.
«ОКНО В КУЛЬТУРУ» И «ЗЕРКАЛО СОЦИУМА»ПОДХОДЫ К ИЗУЧЕНИЮ НЕКРОЛОГИЧЕСКИХ ТЕКСТОВ
Authors: Еремеева С.А. 
Published: December 2024

Современные методы гуманитарных исследований часто ориентированы на своего рода «перепрочтение» уже давно известных источников. С этой точки зрения, определенный интерес представляет некролог. Такая форма текстов о смерти (и о жизни) порождена политическими, экономическими, социальными изменениями, а также изменением личности и представления человека о мире в Новое время. В статье рассматривается многообразие подходов к исследованию некрологов и потенциальное богатство материала, заключенного в них.
Modern methods of humanitarian research are often focused on reinterpreting long-known sources. From this point of view, a type of text such as obituary attracts special attention. This form of publications about death (and about life too) is generated by a whole complex of causes in the Modern Era related to political, economic, and social changes as well as a change in the individual and their worldview. This paper explores the diversity of approaches to the study of obituaries and the potential value of included content.
ФОТОГРАФИИ МАН РЭЯВ СЮРРЕАЛИСТИЧЕСКИХ ИЗДАНИЯХ. КОНТЕКСТЫ
Authors: Аверьянова О.Н. 
Published: December 2024

В период 1920–1930-х гг. Ман Рэй, художник и фотограф американского происхождения, оказался вовлечённым в многочисленные издательские проекты, в т.ч. сюрреалистические. Уже в начале ХХ в. искусство обнаруживает движение в сторону слияния с рекламой, прессой, массовой культурой, что проявляется не только в темах и формах изобразительности, но и в способах его функционирования в областях, традиционно связанных с такими понятиями как «марка» и «бренд». Творчество Рэя, основанное на успешном продвижении собственного бренда MAN RAY, где автор создает вещи, силлогическая роль которых во многом определяется контекстом репрезентации. Художник модернизма как «субъект творчества», чья деятельность теперь связана с коммерческим искусством, последовательно воплощает культурные стратегии, продиктованные временем, создавая «творческую продукцию», соответствующую как задачам авторской самоидентификации, так и потребительского рынка. Фотография, этот новый экспериментальный медиум, будучи независимой от традиционных артистических практик, наглядно демонстрирует недавно оформившиеся связи между искусством и культурой потребления, особенно в издательской сфере. Статья посвящена анализу функционирования фотографии Ман Рэя в системе французской художественной периодики 1920–1930-х гг.
Between the 1920s and the 1930s, Man Ray, an artist and photographer of American origin, was involved in numerous publishing projects, including surrealistic ones. Since the early twentieth century, art reveals a certain movement towards the integration with advertising, press, mass culture, which is manifested not only in the subjects and forms of imagery, but also in the ways of its functioning in the areas traditionally associated with such concepts as “trademark” and “brand”. Ray's work is largely based on the successful promotion of his own brand MAN PAY, where the author creates things, whose syllogistic role is largely determined by the context of representation. The artist of modernism as a “person of oeuvre”, whose activity nowadays is connected to commercial art too, consistently embodies the cultural strategies dictated by time, creating “art products”, corresponding to both the tasks of the author’s self-identification, and the consumer market. Photography, this new experimental medium, which is essentially completely independent of traditional artistic practices, demonstrates the recently formed links between art and consumer culture, especially in the press. The article is devoted to the analysis of functioning of Man Ray’s photography in the system of the French art periodicals of the 1920s–1930s.
СОВЕТСКИЕ УЧЕНЫЕ О СУДЬБЕ«КОЧЕВОЙ ЦИВИЛИЗАЦИИ» (1920-е гг.)
Authors: Синицын Ф.Л. 
Published: December 2024

Статья посвящена подходам советских ученых к судьбе «кочевой цивилизации» в СССР. «Кочевые» регионы занимали в СССР важное стратегическое положение, но при этом не были интегрированы в общегосударственную экономику. Сделан вывод, что советские ученые предлагали осторожный подход к «кочевой цивилизации», основанный на щадящем отношении к природе и отказе от растраты государственных ресурсов на ее «переделку», которая в большинстве «кочевых» регионов не имела перспектив. Дискуссия о судьбе «кочевых» регионов была пресечена властями с началом форсированной модернизации СССР на рубеже 1920-х и 1930-х гг.
The article is devoted to the study of approaches of Soviet scholars to the fate of “nomadic civilization”. This problem was important for the authorities, due to the fact that the “nomadic” regions occupied an important strategic position in the Soviet Union, but they were not Sovietized and integrated into the national economy. It is concluded that the Soviet scientists proposed a cautious approach to “nomadic civilization”, based on a sparing attitude to nature and the refusal to waste public resources on its “alteration”, which in most “nomadic” regions had no prospects. The discussion about the fate of the “nomadic” regions was suppressed by the authorities with the beginning of forced modernization of the USSR at the turn of the 1920s and 1930s.
Круглый стол «ЦИВИЛИЗАЦИЯ И ВАРВАРСТВО:АНТРОПОЛОГИЯ ЛАТЕНТНОГО ВАРВАРСТВА
Authors: Вдовченко Е.В. 
Published: December 2024

8 октября 2018 года в Институте всеобщей истории РАН состоялся международный круглый стол Лаборатории по исследованию цивилизации и варварства. Ежегодный круглый стол, ставший уже традиционным, в этот раз был посвящен теме «Цивилизация и варварство: антропология латентного варварства».
On 8 October 2018, an international workshop took place at the Institute of World History, dedicated to the theme “Civilization and barbarism: the anthropology of latent barbarism”.
Anticancer and Cyclooxygenase Inhibitory Activity of Benzylidene Derivatives of Fenobam and its Thio Analogues
Authors: Hourani Wafa , Deb Pran Kishore , Alhawamdeh Maysa , Al-Shari Nizar , Borah Pobitra , Dahabiyeh Lina A. , Jaber Abdulmuttaleb Yousef , P Nefisath , S Shashiprabha , Dasappa Jagadeesh Prasad , Venugopala Katharigatta N. 
Published: December 2024

Introduction:
A series of benzylidene derivatives of fenobam and its thio analogues
(1-22) have been evaluated for their cytotoxicity against breast cancer (MCF-7,
MDA-MB-231), ovarian cancer (A2780, SKOV-3) and cervical cancer (HELA) cell lines.

Method:
These compounds (1-22) exhibited 72-83% inhibition of Erk activity against the
ovarian cancer cell line (A2780). Compounds 3 and 20 showed the highest DNA damage
effect in Comet Assay against the A2780 cancer cell line as compared to the other tested
analogues (4, 8, 11, 12, and 13) by using % Tail DNA and OTM. Compounds 3, 4, and 11
showed significant activities and selectivity towards COX-2 with 78%, 97%, and 89% inhibition,
as compared to 17%, 57%, and 26% inhibition against COX-1 isoenzyme, respectively.

Results:
Interestingly, molecular docking scores were also in very good agreement with
the experimental results regarding discriminating the selectivity index of the tested compounds
against COX-1 & COX-2 enzymes. Further molecular dynamics (MD) simulation
study revealed that the most selective compound, 13, binds with the COX-2 enzyme in a
similar fashion to that of Rofecoxib, which was further supported by their MD-based free
binding energies (MM-GBSA) of -49.76 ± 4.27 kcal/mol, and -44.84 ±3.78 kcal/mol, respectively.

Conclusion:
Moreover, in silico ADMET predictions showed adequate properties for these
compounds, making them promising leads worthy of further optimization.
Thymol-Loaded Zinc Ferrite Nanoparticles: A Novel Carrier for Enhanced Antimicrobial and Antibiofilm Activity against M. smegmatis through ROS-Mediated Mechanism
Authors: Das Bhabani Shankar , Saragi Ashirbad , Panigrahi Lipsa Leena , Nayak Sunita , Arakha Manoranjan , Bhattacharya Debapriya 
Published: December 2024

Introduction/Objective:
Tuberculosis (TB) remains a persistent global health challenge,
with an increasing incidence of cases and limitations in current treatment strategies. Traditional
therapy involves long drug treatments that can cause side effects and lead to drug-resistant strains,
making treatment less effective. This study aimed to explore the therapeutic potential of a novel
nanoparticle-based delivery system for Thymol (THY), a natural antibacterial bioactive molecule,
to combat Mycobacterium smegmatis, a model organism for Mycobacterium tuberculosis.

Methods:
A nanoparticle-based delivery system was developed using biocompatible Thymolconjugated
Chitosan Zinc Ferrite Nanoparticles (THY-CH-ZnFe2O4 NPs). The nanoconjugates
were characterized for their morphological and chemical properties.

Results:
The characterization of synthesised nanoparticles showed THY-CH-ZnFe2O4 NPs to
exhibit enhanced biocompatibility and antibacterial activity against M. smegmatis compared to
THY alone. The nanoconjugates induced Reactive Oxygen Species (ROS)-mediated damage to the
bacterial cell membrane, effectively inhibiting bacterial replication, dormancy, and biofilm formation.
Additionally, the nanoconjugates demonstrated low cytotoxicity towards the human kidney
cell line.

Conclusion:
The study's findings highlighted a new direction for developing nanoparticle-based
antimycobacterial agents with a wide application in treating TB and other bacterial diseases. The
THY-CH-ZnFe2O4 NPs show promise as a safe and effective therapeutic agent, offering a potential
solution to the limitations of current TB treatment strategies.

conclusion:
The study's findings highlight a new direction for developing nanoparticle-based antimycobacterial agents with wide range applications in treating TB and other bacterial diseases. The THY-CH-ZnFe2O4 NPs show promise as a safe and effective therapeutic agent, offering a potential solution to the limitations of current TB treatment strategies.
Emerging Biomarkers for Assessing Thrombotic Risk in Patients Receiving Direct Oral Anticoagulants (DOACs)
Authors: M. Ashmi Sabana , M. Alwin Simon 
Published: December 2024

Abstract:
Direct Oral Anticoagulants (DOACs) have transformed the management of thrombotic
disorders, offering a more convenient and effective alternative to traditional vitamin K antagonists
(VKAs). However, assessing thrombotic risk in patients treated with DOACS remains crucial due
to the potential for recurrent events. Current clinical risk scores have limitations in predicting and
monitoring venous thromboembolism (VTE) risk in specific DOAC populations. Several emerging
biomarkers show promise in assessing thrombotic risk in patients treated with DOACS. Genetic
factors like VKORC1 and CYP2C9 variants are well-established determinants of warfarin response,
but the genetic landscape for DOAC outcomes appears more complex. Rare variants and
polygenic approaches may play a role in personalizing anticoagulation therapy. Elevated factor
VIII levels are associated with increased VTE recurrence risk after anticoagulation withdrawal in
cancer-associated thrombosis (CAT) patients. In contrast, the circulating tissue factor is not useful
for predicting VTE in this setting. Soluble P-selectin has emerged as a good marker of VTE recurrence,
and its inclusion in the Vienna CATS risk model improves VTE prediction in cancer patients.
While these biomarkers hold promise, larger studies are needed to validate their utility and
establish standardized assays. Caution is warranted in patients at high bleeding risk. Integrating
clinical factors, genetics, and circulating biomarkers will likely optimize thrombotic risk assessment
in patients treated with DOACS. Continued research is crucial to develop personalized anticoagulation
strategies to balance thrombosis and bleeding risks.
Flow-cytometric Analysis of Reactive Oxygen Species in Blood Cells: A Potential Tool for Predicting Restenosis - Insights from a Cohort Study
Authors: Patyar Rakesh Raman , Patyar Sazal , Sharma Yash Paul , Khanduja Krishan Lal 
Published: December 2024

Introduction:
In-stent restenosis (ISR) is a recurrence of a blockage in a section of the
coronary artery that has previously been treated with a stent. Molecular/biochemical pathways underlying
ISR are not fully understood, but inflammation and reactive oxygen species (ROS) induced
oxidative stress play a significant role in the pathogenesis of restenosis. As blood cells are
highly sensitive to oxidative stress and blood is readily accessible compared to other tissues, the
current study flow cytometrically investigated intracellular ROS and cytokine profile of blood
cells as possible markers of restenosis. Flow cytometry is commonly used for detecting ROS and
analyzing oxidative stress but so far, it has not been utilized for prediction of ISR. So, the aim of
the study was to explore the potential of flow cytometric assessment of ROS levels in the blood
cells as predictor of ISR.

Methods:
The study was carried out in a total of 60 patients who had previously undergone coronary
artery stent implantation. They were categorized as Group I - Coronary stent implanted patients
without restenosis (n=30) and Group II - Coronary stent implanted patients with restenosis
(n=30). Sociodemographics, biochemical and angiographic characteristics were assessed. Intracellular
ROS and cytokine estimation in blood cells was done by using flow cytometric analysis.

Results:
Flow cytometric measurements demonstrated a 1.3-fold increase in ROS levels in red
blood cells (RBCs) and 2-fold increase in ROS levels in leucocytes in group II as compared to
group I. Mean serum concentrations of pro-inflammatory cytokines: tumor necrosis factor-α
(33.54 ± 6.48 vs. 20.10 ± 5.61, p <0.001***), interferon-gamma (21.76 ± 4.46 vs. 20.10 ± 5.61, p
<0.001***), interleukin 6 (152.56 ± 30.67 vs. 113.95 ± 23.38, p <0.001***) were found to be
higher in restenotic patients as compared to the non-restenotic patients. Correlation analysis
showed that intracellular ROS levels of RBCs exhibited a significant positive correlation with late
lumen loss in restenotic (r=0.71, p <0.01) as well as non-restenotic patients (r=0.59, p <0.01). Similarly,
intracellular ROS levels of WBCs exhibited a significant positive correlation with late lumen
loss in restenotic (r=0.72, p <0.01) as well as non-restenotic patients (r=0.61, p <0.01).

Conclusion:
This study highlights the role of increased levels of intracellular ROS in blood cells
in the subsequent development of ISR, which can be detected flow cytometrically. The study
suggests that intracellular ROS estimation in blood cells may serve as a potential marker for
restenosis and their flow cytometric analysis may facilitate the prediction of ISR.
The Impact of Diabetes-related Factors on the Severity and Outcome of COVID-19 Infection in Hospitalized Patients: A Descriptive-analytical Study
Authors: Hosseini-Khah Zahra , Mirzaei Ilali Narges , Khasayesi Mina , Sheibani Shirin , Ramezani Fatemeh , Kashi Zahra 
Published: December 2024

Introduction:
The COVID-19 pandemic is having a devastating impact on public
health, with a higher risk of severe illness and mortality in vulnerable groups. Individuals with a
history of diabetes are more prone to severe COVID-19. A collection of hyperglycemia, inflammation,
and impaired immunity in diabetes, especially in poor glycemic control, notably increases the
risk of COVID-19 severity. Hyperglycemia can trigger the release of inflammatory cytokines,
highlighting the intricate relationship between glucose metabolism and inflammation, and contributing
to cytokine storms that worsen COVID-19 severity. Understanding this relationship enables
healthcare providers to develop personalized care strategies for managing blood glucose in diabetic
patients, thereby reducing the risk of severe COVID-19 outcomes. This study aims to identify the
factors that contribute to the severe outcomes of COVID-19 in patients with diabetes, to better
understand and manage this critical combination.

Methods:
A total of 411 patients with COVID-19 infection referred to the Teaching Hospital of
Mazandaran University of Medical Sciences, Sari, were included in this study. The COVID-19
severity was evaluated according to the World Health Organization (WHO) guidelines. All information
including demographic, clinical, and laboratory data as well as severity and outcome of the
disease were compared between diabetic and non-diabetic patients.

Results:
The diabetic patients had higher blood glucose (210.3 ±114.9 mg/dl) compared to nondiabetics
(118.74 ±3.8 mg/dl) upon admission (p=0.0001). Diabetics also experienced more severe
COVID-19 infection (p=0.048). Patients with severe COVID-19 had significantly higher blood
glucose (168.5 ±12.8 mg/dl) than those with non-severe infection (136.6± 6.3 mg/dl) (p=0.013).
Diabetics had higher erythrocyte sedimentation rates (ESR) compared to non-diabetics (52.25±2.4
vs. 43.81±1.8 mm/h, p=0.006). Diabetic patients taking ACEIs/ARBs had more severe COVID-19
infection (p=0.031).

Conclusion:
The study discovered a positive relationship between hyperglycemia and COVID-19
severity, as well as a higher risk of severe COVID-19 among patients taking ACEIs or ARBs.
Computer-aided Drug Design: Innovation and its Application in Reshaping Modern Medicine
Authors: Gupta Pooja , Chanana Arsh , Kulkarni Yukta R. , Narayan Aditya , Havelikar Ujwal , Shanker Oma , Mahato Bhabesh , Singh Dharmendra , Patel Akhilesh , Singh Ravindra Pal , Chawra Himmat Singh 
Published: December 2024

Abstract:
Computer-aided drug design has revolutionized the landscape of drug discovery, accompanied
by a new era of innovation and efficiency of novel therapeutic agents. This article review
explores the diverse innovations and practical applications that have propelled CADD into the forefront
of modern medicine. CADD, a multidisciplinary field at the interaction of biology, chemistry,
and computational science, offers a toolkit for the identification and development of pharmaceutical
compounds. It has the ability to predict molecular interaction between drug and biological targets
with remarkable precision, reducing the dependency on laborious and costly laboratory experiments.
The review deals with two primary domains of CADD: structure-based and ligand-based design.
This three-dimensional protein structure and screening of chemical libraries have led to rational
changes. The analysis of known drug compounds' chemical and biological properties has enabled the
creation of predictive models, opening new routes for drug discovery. The impact of CADD on the
pharmaceutical industry is clear. This review highlights its instrumental role in the development of
antiviral agents, cancer therapeutics, and treatment for various diseases. The transformation potential
of CADD is not without challenges, including the need for substantial computational resources and
the essential requirement of experimental analysis. The synergy between innovation and practical
application is clear, driving unexpected efficiency and precision in the identification of therapeutic
solutions. As pharmaceutical research continues to evolve, the role of CADD remains pivotal, assuring
the rapid translation of scientific innovation into real-world medical advancements.