bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Risk Analysis of a Rainfall-Induced Complex Landslide in Wanzhou County, Three Gorges Reservoir, China
Authors: Xiao Lili , Wang Jiajia , Zhu Yanbo , Zhang Jun 
Published: March 2020

AbstractOn 4 April 2013, a 1.5 million cubic meter landslide occurred in Sunjia Town, Wanzhou County, Three Gorges Reservoir, China. After initiation, the Sunjia landslide traveled about 30 m toward the northeast and destroyed most of the infrastructure in its path. The landslide was triggered by heavy rainfall and previous slope excavations, but this slope also displayed a complicated failure process: the overlying earth slope first deformed and then induced sliding along underlying rock surfaces. Surface displacements that resulted from continuous creeping of the post-event slope were observed by an emergency monitoring system that revealed the disequilibrium state of the slope. To discuss the stability and future movements of the remaining unstable debris deposits, we developed a geotechnical model of the post-slide slope, calculated how it can slide again in an extreme rainfall scenario, and estimated the potential runout distance using the Tsunami Squares method. We then estimated the number of people and the value of the infrastructure threatened by this potential landslide. Lastly, we analyzed the vulnerability of elements at risk and quantitatively evaluated the hazard risk associated with the most dangerous scenario. This quantitative risk analysis provides a better understanding of, and technical routes for, hazard mitigation of rainfall-induced complex landslides.
An Australasian Commentary on the AASM Manual for the Scoring of Sleep and Associated Events
Authors: Jorgensen Greg , Downey Carl , Goldin Jeremy , Melehan Kerri , Rochford Peter , Ruehland Warren 
Published: March 2020

AbstractThe aim of this document was to provide a commentary on the AASM Manual for Scoring of Sleep and Associated Events in an Australasian context. A panel of Australasian sleep professionals developed the commentary. Each member was tasked with reviewing an assigned section and reporting back with potential AASM Manual clarifications and alterations. These suggestions were evaluated by the panel and ultimately resulted in the recommendations in this document. The panel recognised that the AASM manual significantly advanced the standardisation of polysomnography recording, analysis, and reporting; however, there were sections of the AASM Manual where the panel determined there were clarifications, additions, or alterations required. Some of the key panel recommendations included: (1) advice to exclude arousals in awake epochs in the arousal index, (2) recommendation of a single hypopnoea definition, as well as single options for EEG and EOG placements, (3) a minimum duration for the central and mixed components of a mixed apnoea, (4) the addition of a baseline definition for scoring respiratory events, (5) the addition of criteria for defining oxygen desaturation, and (6) advice change so that the scoring and reporting of respiratory effort-related arousals (RERAs) and snoring is ‘recommended’ rather than ‘optional’. While it is anticipated that the recommendations will improve standardisation across Australasian sleep services many of the recommendations are also relevant in a global setting and should be considered for inclusion in future updates of the AASM Manual.
Loss of Nanoparticles in a Particulate Matter Sampling System Applied for Environmental Ultrafine Particle Measurements
Authors: Zoller Julian , Gulden Jonas , Meyer Jörg , Dittler Achim 
Published: March 2020

AbstractCurrent air monitoring networks consist of many measuring stations equipped with sampling systems for the measurement of PM2.5 and PM10 particulate matter. To measure the quantity of particulate matter, the sample air flow is fed to the measuring device through a sampling system. In Baden Württemberg, but also across a wide area in Germany, these sampling systems consist of a Sigma-2-Sampling Head (manufacturer Palas GmbH) and an Intelligent Aerosol Drying System (IADS, manufacturer Palas GmbH). To investigate the suitability of these two common components for sampling of ultrafine particles (< 100 nm), the particle loss inside a sampling system consisting of a Sigma-2-Sampling Head, an IADS, and an additional nafion-dryer (MD-700-24S-1, manufacturer Perma Pure LLC) is measured in this study. A low sampling flow rate of only 0.9 l/min was employed to reduce energy consumption, complexity, and the cost of additional instrumentation. This sample flow rate is typical for scanning mobility particle sizers which are commonly used to measure ultrafine particles. The investigations show a 37% loss of spherical 10 nm copper particles in the used sampling system, which is higher than the allowed losses specified in DIN CEN/TS 16976 for 7 nm particles. The root cause of these losses was investigated and correlations were derived to describe the particle penetration in the sampling system.
Designs and methods for implementation research: Advancing the mission of the CTSA program
Authors: Hwang Soohyun , Birken Sarah A. , Melvin Cathy L. , Rohweder Catherine L. , Smith Justin D. 
Published: March 2020

AbstractIntroduction:The US National Institutes of Health (NIH) established the Clinical and Translational Science Award (CTSA) program in response to the challenges of translating biomedical and behavioral interventions from discovery to real-world use. To address the challenge of translating evidence-based interventions (EBIs) into practice, the field of implementation science has emerged as a distinct discipline. With the distinction between EBI effectiveness research and implementation research comes differences in study design and methodology, shifting focus from clinical outcomes to the systems that support adoption and delivery of EBIs with fidelity.Methods:Implementation research designs share many of the foundational elements and assumptions of efficacy/effectiveness research. Designs and methods that are currently applied in implementation research include experimental, quasi-experimental, observational, hybrid effectiveness–implementation, simulation modeling, and configurational comparative methods.Results:Examples of specific research designs and methods illustrate their use in implementation science. We propose that the CTSA program takes advantage of the momentum of the field's capacity building in three ways: 1) integrate state-of-the-science implementation methods and designs into its existing body of research; 2) position itself at the forefront of advancing the science of implementation science by collaborating with other NIH institutes that share the goal of advancing implementation science; and 3) provide adequate training in implementation science.Conclusions:As implementation methodologies mature, both implementation science and the CTSA program would greatly benefit from cross-fertilizing expertise and shared infrastructures that aim to advance healthcare in the USA and around the world.
Intensive care unit rounding checklists to reduce catheter-associated urinary tract infections
Authors: Nassikas Nicholas J. , Monteiro Joao Filipe G. , Pashnik Barbara , Lynch Judith , Carino Gerardo , Levinson Andrew T. 
Published: March 2020

AbstractObjective:To assess whether the implementation of an intensive care unit (ICU) rounding checklist reduces the number of catheter-associated urinary tract infections (CAUTIs).Design:Retrospective before-and-after study that took place between March 2013 and February 2017.Setting:An academic community hospital 16-bed, mixed surgical, cardiac, medical ICU.Patients:Participants were all patients admitted to the adult mixed ICU and had a diagnosis of CAUTI.Intervention:Initiation of an ICU rounding checklist that prompts physicians to address any use of urinary catheters with analysis comparing the preintervention period before roll out of the rounding checklist versus the postintervention periods.Results:There were 19 CAUTIs and 9,288 urinary catheter days (2.04 CAUTIs per 1,000 catheter days). The catheter utilization ratio increased in the first year after the intervention (0.67 vs 0.60;P= .0079), then decreased in the second year after the intervention (0.53 vs 0.60;P= .0992) and in the third year after the intervention (0.53 vs 0.60;P= .0224). The rate of CAUTI (ie, CAUTI per 1,000 urinary catheter days) decreased from 4.62 before the checklist was implemented to 2.12 in the first year after the intervention (P= .2104). The CAUTI rate was 0.45 in the second year (P= .0275) and 0.96 in the third year (P= .0532).Conclusions:Our study suggests that utilization of a daily rounding checklist is associated with a decrease in the rates of CAUTI in ICU patients. Incorporating a rounding checklist is feasible in the ICU.
Effect of dietary l-carnitine supplementation to sows during gestation and/or lactation on sow productivity, muscle maturation and lifetime growth in progeny from large litters
Authors: Rooney Hazel B. , O’Driscoll K. , Silacci P. , Bee G. , O’Doherty J. V. , Lawlor P. G. 
Published: March 2020

AbstractGenetic selection for increased sow prolificacy has resulted in decreased mean piglet birth weight. This study aimed to investigate the effect of l-carnitine (CAR) supplementation to sows during gestation and/or lactation on sow productivity, semitendinosus muscle (STM) maturity and lifetime growth in progeny. Sixty-four sows were randomly assigned to one of the four dietary treatments at breeding until weaning: CONTROL (0 mg CAR/d), GEST (125 mg CAR/d during gestation), LACT (250 mg CAR/d during lactation) and BOTH (125 mg CAR/d during gestation and 250 mg CAR/d during lactation). The total number of piglets born per litter was greater for sows supplemented with CAR during gestation (17·3 v. 15·8 (sem 0·52); P < 0·05). Piglet birth weight (total and live) was unaffected by sow treatment (P > 0·05). Total myofibre number (P = 0·08) and the expression level of selected myosin heavy chain genes in the STM (P < 0·05) were greater in piglets of sows supplemented with CAR during gestation. Pigs from sows supplemented with CAR during gestation had lighter carcasses at slaughter than pigs from non-supplemented sows during gestation (83·8 v. 86·7 (sem 0·86) kg; P < 0·05). In conclusion, CAR supplementation during gestation increased litter size at birth without compromising piglet birth weight. Results also showed that the STM of piglets born to sows supplemented with CAR during gestation was more developed at birth. However, carcass weight at slaughter was reduced in progeny of sows supplemented with CAR during gestation. The CAR supplementation strategy applied during gestation in this study could be utilised by commercial pork producers to increase sow litter size and improve offspring muscle development.
Design and expression of polytopic construct of cathepsin-L1, SAP-2 and FhTP16.5 proteins of Fasciola hepatica
Authors: Aghamolaei S. , Kazemi B. , Bandehpour M. , Ranjbar M.M. , Rouhani S. , Javadi Mamaghani A. , Tabaei S.J.S. 
Published: March 2020

Abstract
The enzyme-linked immunosorbent assay (ELISA) technique can play an important role in the early detection of fascioliasis. However, they have some diagnostic limitations, including cross-reaction with other helminths. It seems that the combination of recombinant parasite proteins as antigen can reduce these problems. Hence, the present study was aimed to design and confirm the antigenic recombinant multi-epitope (rMEP) construct of three protein epitopes (linear and conformational B-cell epitopes) of the parasite using immunoinformatic tools. For this purpose, the tertiary structures of Fasciola hepatica cathepsin-L1, saposin-like protein 2 and 16.5-kDa tegument-associated protein were predicted using the I-TASSER server. Validation of the modelled structures was performed by Ramachandran plots. The antigenic epitopes of the proteins were achieved by analysing the features of the IEDB server. The synthesized gene was cloned into the pET-22b (+) expression vector and transformed into the Escherichia coli BL21. Sodium dodecyl sulfate polyacrylamide gel electrophoresis was used to verify and analyse the expression of the rMEP protein. Western blotting was utilized to confirm rMEP protein immunogenicity in two forms, one using an anti-His tag antibody and the other with human pooled sera samples (fascioliasis, non-fascioliasis and negative control sera). Our results demonstrated that the rMEP designed for the three proteins of F. hepatica was highly antigenic, and immune-detection techniques confirmed the antigen specificity. In conclusion, the presented antigenic multi-epitope may be very helpful to develop serodiagnostic kits such as indirect ELISA to evaluate the proper diagnosis of fascioliasis in humans and ruminants.
In vitro nematocidal activity of commercial fatty acids and β-sitosterol against Haemonchus contortus
Authors: Pineda-Alegría J.A. , Sánchez J.E. , González-Cortazar M. , von Son-de Fernex E. , González-Garduño R. , Mendoza-de Gives Pedro , Zamilpa A. , Aguilar-Marcelino L. 
Published: March 2020

Abstract
Haemonchus contortus is a haematophagous gastrointestinal nematode (GIN) that causes severe anaemia and even death in small ruminants, negatively impacting the economic viability of farms. Traditionally, this parasite has been controlled with chemical compounds; however, inadequate use of these types of products has favoured the emergence of anthelmintic resistance. Therefore, it is necessary to search for alternatives for GIN control. Previous studies have reported the anthelmintic activity of edible mushroom extracts against H. contortus. A recent study reported that a fraction constituted of different fatty acids and β-sitosterol isolated from the basidiomata of the edible mushroom Pleurotus djamor ECS-123 has ovicidal and larvicidal activity against H. contortus. Thus, this study aimed to assess the anthelmintic activity of the pure molecules: pentadecanoic acid, palmitic acid, β-sitosterol, stearic acid and linoleic acid. For this purpose, an egg-hatching inhibition test was carried out in which the compounds were evaluated individually and in combination at a final concentration of 20 mg mL−1. Furthermore, larval mortality was assessed using a combination of the five commercial compounds previously mentioned at different concentrations (1.25–20 mg mL−1). Palmitic acid and stearic acid, in some combinations, inhibited H. contortus egg hatching by 100%. On the other hand, in the larval mortality test, the combination of the five compounds showed dose-dependent behaviour, and 100% mortality was obtained 24 h post-incubation. Pure molecules and their combinations have anthelmintic-like activity against the eggs and larvae of H. contortus.
Endoscopic visualisation of the round window during cochlear implantation
Authors: Jain A , Sharma R , Passey J C , Meher R , Bansal R 
Published: March 2020

AbstractBackgroundEndoscopes provide a magnified view of the middle ear and visualisation of hidden areas. Otoendoscopes facilitate excellent visualisation of the round window niche during cochlear implantation.ObjectiveTo compare microscopic and endoscopic visualisation of the round window membrane during cochlear implantation in 20 patients.MethodsTwenty patients who underwent cochlear implantation were included in the study. After maximum exposure of the round window, the accessibility of the round window membrane was graded according to the St Thomas Hospital classification, first by microscope and then by endoscope.ResultsWith the use of the endoscope, visualisation of the round window membrane improved in all the patients as compared to the microscope. The electrode array was inserted via a round window or extended round window approach in all but two cases; the latter cases required bony cochleostomy because of unfavourable anatomy.ConclusionThe main benefit of endoscope-assisted cochlear implantation is improved visibility of the round window region.
Voice outcome after vocal fold injection augmentation with carboxymethyl cellulose versus calcium hydroxyapatite
Authors: Cohen J T , Benyamini L 
Published: March 2020

AbstractBackgroundVocal fold injection augmentation is a recognised treatment modality for glottic insufficiency. Causes of glottal closure insufficiency include vocal fold paralysis, paresis, atrophy, sulcus vocalis, scarring and vocal fold deficiency after laryngeal surgery. A variety of materials exist for injection augmentation. This study aimed to compare voice improvement after injection augmentation between two injectable materials: carboxymethyl cellulose and calcium hydroxyapatite.MethodThis retrospective study included 66 consecutive patients with glottic insufficiency who underwent injection augmentation.ResultsAmong the patients who received their first injection augmentation with carboxymethyl cellulose and their second injection augmentation with calcium hydroxyapatite (n = 28), voice quality improved significantly after both injection augmentations. No significant differences were observed in any of the objective and subjective voice quality measurements examined following carboxymethyl cellulose and calcium hydroxyapatite injections.ConclusionVoice improvement after injection augmentation depends mainly on the improvement of glottic closure, rather than the injection material.
Phylogenetic evidence for an expanded circumscription of Gabura (Arctomiaceae)
Authors: Magain Nicolas , Spribille Toby , DiMeglio Joseph , Nelson Peter R. , Miadlikowska Jolanta , Sérusiaux Emmanuël 
Published: March 2020

AbstractSince the advent of molecular taxonomy, numerous lichen-forming fungi with homoiomerous thalli initially classified in the family Collemataceae Zenker have been transferred to other families, highlighting the extent of morphological convergence within Lecanoromycetes O. E. Erikss. & Winka. While the higher level classification of these fungi might be clarified by such transfers, numerous specific and generic classifications remain to be addressed. We examined the relationships within the broadly circumscribed genus Arctomia Th. Fr., which has been the recipient of several transfers from Collemataceae. We demonstrated that Arctomia insignis (P. M. Jørg. & Tønsberg) Ertz does not belong to Arctomia s. str. but forms a strong monophyletic group with Gabura fascicularis (L.) P. M. Jørg. We also confirmed that Arctomia borbonica Magain & Sérus. and the closely related Arctomia insignis represent two species. We formally transferred A. insignis and A. borbonica to the genus Gabura Adans. and introduced two new combinations: Gabura insignis and Gabura borbonica. We reported Gabura insignis from Europe (Scotland and Ireland) for the first time. While material from Europe and North America is genetically almost identical, specimens from Madagascar, South Africa and Reunion Island belong to three distinct phylogenetic lineages, all of which are present in the latter area and may represent distinct species. In its current circumscription, the genus Gabura may contain up to six species, whereas Arctomia s. str. includes only two species (A. delicatula Th. Fr. and A. teretiuscula P. M. Jørg.). The Gabura insignis group is shown to have an unexpectedly large, subcosmopolitan distribution. With the extended sampling from Arctomiaceae Th. Fr., the placement of Steinera sorediata P. James & Henssen in the genus Steinera Zahlbr. is confirmed and the presence of a new Steinera species from Chile is highlighted.
Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014–2016: a distributed lag nonlinear model
Authors: Gu Shaohua , Li Decheng , Lu Beibei , Huang Ruixue , Xu Guozhang 
Published: March 2020

Abstract
Hand, foot and mouth disease (HFMD) has high prevalence around the world, with serious consequences for children. Due to the long survival period of HFMD virus in ambient air, air pollutants may play a critical role in HFMD epidemics. We collected data on daily cases of HFMD among children aged 0–14 years in Ningbo City between 2014 and 2016. Distributed lag nonlinear models were used to assess the effects of particulate matter (PM2.5), sulphur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the daily incidence of HFMD among children, with analyses stratified by gender and age. Compared with moderate levels of air pollution, high SO2 levels had a relative risk (RR) of 2.32 (95% CI 1.42–3.79) and high NO2 levels had a RR of 2.01 (95% CI 1.22–3.31). The RR of O3 was 2.12 (95% CI 1.47–3.05) and that of PM2.5 was 0.77 (95% CI 0.64–0.92) at moderate levels of air pollution. Specifically, high levels of SO2 and NO2 had RRs of 2.39 (95% CI 1.44–3.96) and 2.02 (95% CI 1.21–3.39), respectively, among 0–4-year-old children, while high O3 had an RR of 2.31 (95% CI 1.09–4.89) among 5–14-year-old children. Our findings suggest significant associations of high SO2 and NO2 levels and moderate O3 levels in HFMD epidemics, and also indicate that air pollution causes lagged effects on HFMD epidemics. Our study provides practical and useful data for targeted prevention and control of HMFD based on environmental evidence.
Prehospital Vital Signs Accurately Predict Initial Emergency Department Vital Signs
Authors: Trust Marc D. , Schellenberg Morgan , Biswas Subarna , Inaba Kenji , Cheng Vincent , Warriner Zachary , Love Bryan E. , Demetriades Demetrios 
Published: March 2020

AbstractIntroduction:Prehospital vital signs are used to triage trauma patients to mobilize appropriate resources and personnel prior to patient arrival in the emergency department (ED). Due to inherent challenges in obtaining prehospital vital signs, concerns exist regarding their accuracy and ability to predict first ED vitals.Hypothesis/Problem:The objective of this study was to determine the correlation between prehospital and initial ED vitals among patients meeting criteria for highest levels of trauma team activation (TTA). The hypothesis was that in a medical system with short transport times, prehospital and first ED vital signs would correlate well.Methods:Patients meeting criteria for highest levels of TTA at a Level I trauma center (2008-2018) were included. Those with absent or missing prehospital vital signs were excluded. Demographics, injury data, and prehospital and first ED vital signs were abstracted. Prehospital and initial ED vital signs were compared using Bland-Altman intraclass correlation coefficients (ICC) with good agreement as >0.60; fair as 0.40-0.60; and poor as <0.40).Results:After exclusions, 15,320 patients were included. Mean age was 39 years (range 0-105) and 11,622 patients (76%) were male. Mechanism of injury was blunt in 79% (n = 12,041) and mortality was three percent (n = 513). Mean transport time was 21 minutes (range 0-1,439). Prehospital and first ED vital signs demonstrated good agreement for Glasgow Coma Scale (GCS) score (ICC 0.79; 95% CI, 0.77-0.79); fair agreement for heart rate (HR; ICC 0.59; 95% CI, 0.56-0.61) and systolic blood pressure (SBP; ICC 0.48; 95% CI, 0.46-0.49); and poor agreement for pulse pressure (PP; ICC 0.32; 95% CI, 0.30-0.33) and respiratory rate (RR; ICC 0.13; 95% CI, 0.11-0.15).Conclusion:Despite challenges in prehospital assessments, field GCS, SBP, and HR correlate well with first ED vital signs. The data show that these prehospital measurements accurately predict initial ED vitals in an urban setting with short transport times. The generalizability of these data to settings with longer transport times is unknown.