bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, risk factors and re‐exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
Authors: Engelkes Marjolein , Baan Esme J. , de Ridder Maria A. J. , Svensson Elisabeth , Prieto‐Alhambra Daniel , Lapi Francesco , Giaquinto Carlo , Picelli Gino , Boudiaf Nada , Albers Frank , Evitt Lee A. , Cockle Sarah , Bradford Eric , Van Dyke Melissa K. , Suruki Robert , Rijnbeek Peter , Sturkenboom Miriam C. J. M. , Janssens Hettie M. , Verhamme Katia M. C. 
Published: March 2020

AbstractBackgroundThere are sparse real‐world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma‐related rehospitalization in children with asthma.MethodsAsthma patients 5‐17 years old with ≥1 year of follow‐up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008‐2013. Asthma was defined as ≥1 asthma‐specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high‐dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses.ResultsThe cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient‐years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3‐45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year.ConclusionsIn a real‐world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma.
Kinetics of IgA and eosinophils following a low‐dose, predominantly Haemonchus contortus infection of Boer goats
Authors: Hayyan Basripuzi N. , Sharma Reuben S.K. , Raimy Nurulaini , Nisha Mehru , Hussain Khalida , Busin Valentina M. , Jenvey Caitlin J. , Cairns Callum , Stear Michael J. 
Published: March 2020

AbstractAimsMost breeds of goat are more susceptible to nematode infection than sheep, and this appears to be a consequence of less effective immune responses. Several papers have considered the effectiveness of eosinophils and immunoglobulin A (IgA) in goats but differences in the induction of responses have not been studied in the same detail. The aim of this study was to look at the induction of eosinophil and IgA responses in Boer goats reared indoors under intensive conditions.Methods and resultsThe goats were experimentally infected with a low dose of 2400 Haemonchus contortus, Trichostrongylus spp. and Oesophagostomum spp. at a 6:1:1 ratio. Faecal egg counts (FEC), packed cell volume (PCV), IgA activity against third‐stage larvae and peripheral eosinophilia were measured twice a week for eight weeks. The infection generated an IgA response but did not significantly increase peripheral eosinophilia in the 25 infected kids compared with the 4 control animals. FEC was not associated with IgA activity or eosinophilia.ConclusionA detailed analysis of IgA and eosinophil responses to deliberate nematode infection in Boer goats showed that there was an increase in nematode‐specific IgA activity but no detectable eosinophil response. In addition, there was no association between increased IgA activity or eosinophilia with egg counts and worm burdens. These suggest that IgA and eosinophils do not act to control nematode infection in goats.
Reducing waiting times in the Italian NHS: The case of Emilia‐Romagna
Authors: Toth Federico 
Published: March 2020

AbstractIn 2015, the Emilia‐Romagna Regional Government implemented a plan to reduce waiting times for elective outpatient procedures. The objective set by the regional government establishes that at least 90 per cent of specialist services are to be provided within the following maximum waiting times: 30 days for the first specialist consultation, and 60 days for diagnostic tests. The plan adopted by the Emilia‐Romagna Regional Government is of particular interest because it encompasses a combined strategy. Some of the interventions envisaged in the plan aim at increasing the supply of specialist services. Others address the demand side, seeking to reduce inadequate requests and discourage no‐shows by patients. And others focus on combining supply and demand and neutralizing the effects of some perverse incentives. The Emilia‐Romagna plan appears to have had a successful outcome. In the first 4 years of implementation, the 90 per cent target has not only been achieved but also widely exceeded.
Phylogeny and classification of Leptophlebiidae (Ephemeroptera) with an emphasis on Neotropical fauna
Authors: Monjardim Marina , Paresque Roberta , Salles Frederico F. 
Published: March 2020

AbstractMayflies from the family Leptophlebiidae are cosmopolitan and highly diverse morphologically; they are also the largest family in numbers of genera and the second in number of species in the order Ephemeroptera. In spite of their broad diversity and the efforts employed to understand the evolution of this group, the internal classification of Leptophlebiidae remains controversial at all levels. More recently, important changes have been incorporated into the systematics of the family, increasing the number of subfamilies (from two to six) and recognizing several tribes. We present a phylogeny of the family based on 153 taxa (53 genera) and two molecular markers, representing 1655 bp, and verify the taxonomic status of the subfamilies, tribes and complexes. Based on these results, the number of subfamilies has been increased from six to eight and one new tribes and two new subtribes have been added. In addition, new ranks are proposed and the concept of Atalophlebiinae revised, including genera with distributions in the Australasian and Neotropical regions.
A single‐centre review of iatrogenic anaemia in adult intensive care
Authors: Holland James , Peralta Rita M. , Moss Rachel L. , Feane Kelly , Uprichard James 
Published: March 2020

AbstractObjectives(a) To quantify the volume of diagnostic blood loss (DBL) and evaluate its impact on intensive care unit (ICU) patients, (b) examine the correlation between severity of disease and DBL and (c) identify potentially vulnerable patient subgroups.BackgroundIatrogenic anaemia is an important problem amongst ICU patients, with significant daily DBL.MethodsA single‐centre observational cohort study was conducted at St George's Hospital, London, cardiac and general ICU. Forty patients were included in the study. Variables measured were volume of blood collected and discarded on a daily basis, Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of phlebotomy, haemoglobin concentration before and after admission to ICU, reason for admission and complications developed in ICU.ResultsMean (SD) total volume drawn per patient per day over 4 days was 86.3 mL (19.58). Nearly 30% of the total blood taken was discarded. There was a strong positive correlation between patients admitted because of sepsis and volume of DBL (P < .01), APACHE II score and volume taken (P = .01), patients who developed respiratory failure requiring ventilation and volume taken (P < .01) and patients who had received a blood transfusion and volume taken (P < .01). Haemoglobin concentration on discharge was negatively associated with DBL volume (P < .01).ConclusionHigh volumes of blood were taken and discarded from the study population, possibly reflecting the fact that there are no guidelines for ICU staff in terms of the amount of blood that needs to be withdrawn in order to “prime” access lines.
Impact of development and management options on water resources of the upper Mara River Basin of Kenya
Authors: Omonge Paul , Herrnegger Mathew , Gathuru Gladys , Fürst Josef , Olang Luke 
Published: March 2020

AbstractThis study employed the Water Evaluation and Planning model to evaluate selected policy‐based water development and management options on water resources of the upper Mara Basin of Kenya. The major water resources of the region were identified and quantified to establish the current demand versus supply status. Data on domestic water consumption, agricultural demand and industrial consumption were collected through a rigorous fieldwork campaign and used to define the current state of water use and demand. The water resource model was calibrated and validated against observed discharges and subsequently used to simulate the selected policy‐based options. Results indicate that an increase between 49% and 180%, depending on the assumed scenario, in annual water demand is expected by the year 2030. As a conclusion, the simulations demonstrate that there is both the need and significant potential to reduce the demand by implementing water conservation measures.
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: March 2020

Applied Economics and Finance (AEF) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 2 Ali Massoud, Sohag University, EgyptAndrey Kudryavtsev, The Max Stern Yezreel Valley Academic College, IsraelAyoub Taha Sidahmed, SIU, SudanBasanta K. Pradhan, University of Delhi Enclave, IndiaDjebali Nesrine, University of Jendouba, TunisiaGetamesay Bekele Meshesha, Debre Berhan University, EthiopiaHe Nie, Jinan University, ChinaIgor Matyushenko, School of Foreign Economic Relations and Touristic Business, UkraineKembo Bwana, College of Business Education, TanzaniaMarco Muscettola, Independent Researcher-Credit Risk Manager, ItalyMarwa Biltagy, Cairo University, Faculty of Economics and Political Science, EgyptMurad Harasheh, University of Milan-Bicocca, ItalyNicolas Afflatet, University of the Federal Armed Forces, GermanyOltiana Muharremi Pelari, University of Vlora, AlbaniaOlubukunola Ranti Uwuigbe, Covenant University, NigeriaPatrycja Kowalczyk-Rolczynska, Wroclaw University of Economics, PolandPayal Chadha, University of Wales Prifysgol Cymru, KuwaitRajeev Rana, APB Govt. P.G. College, IndiaRamona Orastean, Lucian Blaga University of Sibiu, RomaniaRichard Nguyen, Alliant International University, USARomeo Victor Ionescu, Dunarea de Jos University, RomaniaVictoria Cociug, Academy of Sciences of Moldova, Moldova Nikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Vitamin D deficiency cardiomyopathy in Scotland: a retrospective review of the last decade
Authors: Hunter Lindsay , Ferguson Richard , McDevitt Helen 
Published: March 2020

ObjectiveTo determine the incidence, demography and prognosis of vitamin D deficiency dilated cardiomyopathy (DCM) in Scotland over the last decade.Study designA retrospective review of cases of vitamin D deficiency DCM presenting to a national paediatric cardiac centre between 1 January 2008 and 1 January 2018. The departmental database and electronic and paper case notes were used to identify patients and extract data.ResultsSix patients were identified (three male), three of whom were Caucasian. Median age at presentation was 206 days (range 2–268.) All six patients had high serum parathyroid hormone levels (median 45 pmol/L, range 27–120 pmol/L), a sensitive marker of total body calcium deprivation secondary to vitamin D deficiency. All patients demonstrated clinical and echocardiographic improvement following high dose vitamin D treatment. No patients required cardiac transplant, and only one patient required extracorporeal life support as a bridge to recovery. After an initial improvement, one child died at 5 months as a result of respiratory infection. Three patients lived within some of the most deprived areas in Scotland.ConclusionsThis case series demonstrates a previously unreported demographic in Scotland, as 50% of cases presented in Caucasian children. Although vitamin D deficiency DCM is relatively rare, it is wholly preventable. Our study confirms that vitamin D deficiency cardiomyopathy is reversible with prompt identification and supplementation. The current implementation of public health policy in the UK is failing to prevent children from developing the most severe manifestation of vitamin D deficiency.
Does changing to brighter road lighting improve road safety? Multilevel longitudinal analysis of road traffic collision frequency during the relighting of a UK city
Authors: Marchant Paul , Hale James David , Sadler Jon Paul 
Published: March 2020

Background
A step change in the night environment is taking place, with the large-scale installation of bright, broad-spectrum road lighting such as white light-emitting diodes (LEDs). One justification for this is a reduction in road traffic collisions (RTCs). This study aimed to estimate the effect of new lighting on personal injury RTCs within a large UK city.

Methods
We analysed a 9-year time series of weekly RTC personal injury counts in 132 areas of the city using multilevel modelling. The RTC rate over a full 24-hour period was the primary outcome; darkness and daylight RTC rates were secondary. The background change in RTC rate was separated from the change associated with the number of newly installed bright lamps by including a polynomial underlying time trend for the logarithm of the mean number of collisions per week for each area. The study was based on a rigorous, predesigned and archived protocol.

Results
Within-area coefficients for the broad lighting effect were positive; as the number of bright lamps in an area increased, so did the RTC rate. The estimate for the increase in the within-area 24-hour RTC rate is 11% (95% CI 2% to 20%). The estimate of darkness-only RTCs is 16% (95% CI 2% to 32%). If the effect of lighting on darkness RTC rate is adjusted by that for daylight, one obtains 4% (95% CI −12% to +23%).

Conclusion
No evidence was found for bright lamps leading to an improvement in road safety in any of the analyses. For this city, introducing brighter road lighting may have compromised safety rather than reducing harm.
Female UK Army Service personnel are at greater risk of work-related morbidity on return to duty postpartum
Authors: Cordell Robin F , Wickes C K , Casey A , Greeves J P 
Published: March 2020

IntroductionThe 2016 Interim Report on the Health Risks to Women in Ground Close Combat Roles highlighted an increased risk of skeletal injury and significant physiological changes, including increased ligament laxity and decreased bone mineral content, during the postpartum period. The report called for further research and a re-evaluation of postpartum policy to optimise the return of female Service personnel to arduous employment. The purpose of this study was to determine whether returning to duty is at greater risk of injury and illness in the first year postpartum than they were prepregnancy.MethodsFifty-five female UK Army Service personnel aged 18–41 years, who had given birth in the previous 4 years, completed a lifestyle questionnaire and gave written consent for a review of their medical records. The number of working days lost (WDL) due to illness, injury and combined illness and injury was obtained from medical records, for 1 year prepregnancy and 1 year postpartum. Female Service personnel returned to duty at different time-points postpartum, so data were expressed as WDL/week.ResultsWDL/week due to illness and combined illness and injury were higher postpartum compared with prepregnancy (p<0.05). WDL/week due to combined illness and injury was significantly lower prepregnancy (p<0.05) and at 0–26 weeks postpartum (p<0.05), compared with 26–52 weeks postpartum.ConclusionsPostpartum female UK Army Service personnel are at greater risk of illness and a combination of illness and injury in the year after giving birth, compared with prepregnancy. The study suggests female Service personnel are unprepared for the demands of full active duty in the first year postpartum.
Endovascular robotic: feasibility and proof of principle for diagnostic cerebral angiography and carotid artery stenting
Authors: Sajja Kalyan Chekravarthy , Sweid Ahmad , Al Saiegh Fadi , Chalouhi Nohra , Avery Michael B , Schmidt Richard F , Tjoumakaris Stavropoula I , Gooch Michael Reid , Herial Nabeel , Abbas Rawad , Zarzour Hekmat , Romo Victor , Rosenwasser Robert , Jabbour Pascal 
Published: March 2020

BackgroundRobots in surgery aid in performing delicate, precise maneuvers that humans, with inherent physical abilities, may be limited to perform. The CorPath 200 system is FDA approved and is being implemented in the US for interventional cardiology procedures. CorPath GRX robotic-assisted platform is the next-generation successor of CorPath 200.ObjectiveTo discuss the feasibility and early experience with the use of the CorPath GRX robotic-assisted platform for neuroendovascular procedures, including transradial diagnostic cerebral angiograms and transradial carotid artery stenting.MethodsThe cases of 10 consecutive patients who underwent neuroendovascular robotic-assisted procedures between December 1, 2019 and December 30, 2019, are presented.ResultsSeven patients underwent elective diagnostic cerebral angiography, and three patients underwent carotid artery angioplasty and stenting using the CorPath GRX robotic-assisted platform. All procedures were performed successfully, and no complications were encountered. Conversion to manual control occurred in three diagnostic cases because of a bovine arch that was previously not known. The fluoroscopy time and the procedure time continued to improve with subsequent procedures as we streamlined the workflow.ConclusionThis series demonstrates the early use of this technology. It could potentially be used in the near future for acute stroke interventions in remote geographic locations and in places where a neurointerventionalist is not available.
Remarks on η-parallel real hypersurfaces in ℂP2 and ℂH2
Authors: Wang Yaning 
Published: March 2020

Let [Formula: see text] be a three-dimensional real hypersurface in a nonflat complex space form of complex dimension two. In this paper, we prove that [Formula: see text] is [Formula: see text]-parallel with two distinct principal curvatures at each point if and only if it is locally congruent to a geodesic sphere in [Formula: see text] or a horosphere, a geodesic sphere or a tube over totally geodesic complex hyperbolic plane in [Formula: see text]. Moreover, [Formula: see text]-parallel real hypersurfaces in [Formula: see text] and [Formula: see text] under some other conditions are classified and these results extend Suh’s in [Characterizations of real hypersurfaces in complex space forms in terms of Weingarten map, Nihonkai Math. J. 6 (1995) 63–79] and Kon–Loo’s in [On characterizations of real hypersurfaces in a complex space form with [Formula: see text]-parallel shape operator, Canad. Math. Bull. 55 (2012) 114–126].
CarePre
Authors: Jin Zhuochen , Cui Shuyuan , Guo Shunan , Gotz David , Sun Jimeng , Cao Nan 
Published: March 2020

Clinical decision support systems are widely used to assist with medical decision making. However, clinical decision support systems typically require manually curated rules and other data that are difficult to maintain and keep up to date. Recent systems leverage advanced deep learning techniques and electronic health records to provide a more timely and precise result. Many of these techniques have been developed with a common focus on predicting upcoming medical events. However, although the prediction results from these approaches are promising, their value is limited by their lack of interpretability. To address this challenge, we introduce CarePre, an intelligent clinical decision assistance system. The system extends a state-of-the-art deep learning model to predict upcoming diagnosis events for a focal patient based on his or her historical medical records. The system includes an interactive framework together with intuitive visualizations designed to support diagnosis, treatment outcome analysis, and the interpretation of the analysis results. We demonstrate the effectiveness and usefulness of the CarePre system by reporting results from a quantities evaluation of the prediction algorithm, two case studies, and interviews with senior physicians and pulmonologists.
Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice
Authors: Orekhova Anna , Geisz Andrea , Sahin-Tóth Miklós 
Published: March 2020

Alcoholic pancreatitis is a multifactorial, progressive, inflammatory disorder of the pancreas. Alcohol initiates pancreatitis and promotes its progression in the context of genetic susceptibility and/or other environmental risk factors such as smoking. Genetic mutations can cause digestive enzyme misfolding, which induces endoplasmic reticulum (ER) stress and elicits pancreatitis. Here, we tested the hypothesis that alcohol synergizes with misfolding in promoting ER stress and thereby accelerates chronic pancreatitis progression. To this end, we fed an ethanol-containing diet to CPA1 N256K mice, which carry the human p.N256K CPA1 mutation and develop spontaneous chronic pancreatitis. Inexplicably, CPA1 N256K mice suffered generalized seizures after 2–3 wk of ethanol feeding, which resulted in high mortality and the early termination of the study. Analysis of CPA1 N256K mice euthanized after 3–3.5 wk of ethanol feeding revealed more severe chronic pancreatitis associated with significantly increased Hspa5 [ER chaperone immunoglobulin heavy chain-binding protein (BiP)] mRNA levels when compared with CPA1 N256K mice on a control liquid diet. In contrast, ethanol feeding of C57BL/6N mice for 4 wk increased Hspa5 levels to a lesser degree and caused no pancreatitis. We conclude that ethanol feeding synergizes with the misfolding CPA1 mutant in promoting ER stress and thereby accelerates progression of chronic pancreatitis in CPA1 N256K mice. NEW & NOTEWORTHY Alcoholic pancreatitis is a multifactorial, progressive, inflammatory disorder of the pancreas. This study demonstrates that alcohol synergizes with digestive enzyme misfolding in promoting endoplasmic reticulum stress and thereby accelerates progression of chronic pancreatitis.