Abstract B052: Use of video education interventions to increase underrepresented minority cancer survivor participation in clinical trials: A review
Authors: Nolan Timiya S. , Chan Ya-Ning , Bryant Ashley Leak , Walker Jennifer S. , Bell Ana' M. , Hirschey Rachel 
Published: September 2020

Abstract
Background Less than 5% of eligible adult cancer survivors participate in cancer clinical trials. Compared to 1.2% of non-Hispanic Whites, underrepresented minority (URM) survivors are less likely to participate in clinical trials (0.7% of Blacks, P &lt; .001; 0.4% of Hispanics, P &lt; .001). Yet, URMs experience disparities in cancer-related morbidity and mortality. Clinical trials need adequate URM representation in samples to generalize findings for reduction of cancer disparities. There is a critical need to identify interventions that increase URM participation in clinical trials. Common barriers to URM participation are lack of knowledge, lack of access, fear, and mistrust. Thus, educating URM survivors about clinical trials with videos may be an effective intervention. The purpose of this systematic review was to understand the use of video education interventions to increase URM survivor participation in clinical trials. Methods In October 2018, the authors searched Web of Science, Embase, PubMed, Cochrane, PsycInfo, and CINAHL databases for all articles that described or tested video interventions aimed at increasing adult, URM survivor participation in clinical trials. Two authors independently screened articles for inclusion, appraised quality, and abstracted relevant data. All authors synthesized the data into themes. Results The search yielded 2,518 articles. Of these, seven articles describing six distinct interventions met criteria for inclusion. Quality of the included studies appraised as fair to good. Though the six interventions reduced barriers to participation in clinical trials, they reported variable findings on readiness to enroll and/or actual participation of Black and Hispanic survivors of various cancers (largely breast). Five themes emerged: 1) cultural sensitivity application in video development and delivery; 2) video content aimed to educate and change attitudes about clinical trials; 3) video interventions were feasible but lacked power to detect effects; 4) predictors of readiness and participation within URMs were not consistently related to socioeconomic factors; and 5) racially congruent clinical trial coordinators, along with videos, may yield more favorable intervention effects. Conclusions Video interventions are well-received by URM survivors and may improve URM representation in clinical trials, yet they are underutilized. With widening cancer disparities and rapidly changing cancer care, more rigorous studies are needed to establish best practices for video interventions used to increase URM participation in clinical trials.
Note: This abstract was not presented at the conference.
Citation Format: Timiya S. Nolan, Ya-Ning Chan, Ashley Leak Bryant, Jennifer S. Walker, Ana' M. Bell, Rachel Hirschey. Use of video education interventions to increase underrepresented minority cancer survivor participation in clinical trials: A review [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B052.