bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evaluation of the Primary Circuit Passivation Layer Formed After Hot Functional Tests at the EMO3
Authors: Kůs Pavel , Kronďák Martin , Skala Martin , Kobzová Alena , Brabec Petr , Halodová Patricie , Mihóková Janka , Tkáč Štefan , Černá Anna 
Published: December 2020

Abstract
The presented article outlines and describes the processes involved in the creation and testing of the passivation layer that was created during hot functional tests (HFTs) at the third unit of the nuclear power plant (NPP) Mochovce. The article is divided into several sections. In Sec. 1 is the description of the hot tests on the third block, in particular the chemical regime, i.e., the formation of hydrogen or the necessary adjustment of the pH value. Sec. 2 of the article describes the evaluation of the passivation layer using instrumental techniques, i.e., Raman microscopy, scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy. The results obtained by using these techniques provided a comprehensive view of the resulting layer and clearly defined its' structure. The measurement revealed that a passivation layer was formed, the inner layer of which is enriched with a chrome element. The upper part of the passivation layer was composed of iron oxides, mainly magnetite.
Application of Alumina-Based Ceramic Paste for High-Temperature Electronics Packaging
Authors: Nasiri Ardalan , Ang Simon 
Published: December 2020

AbstractAlumina-based die-attach and encapsulation for high-temperature (300–500 °C) electronic packaging were investigated. The alumina paste material comprises aluminum dihydric phosphate as a binder and alumina powder as a filler with embedded nano-aluminum nitride and nanosilica powders to promote its curing process, reduce its curing tension, and increase its bond shear strength. The chip-to-substrate bond strength was enhanced and met the MIL-STD-883 2019.9 requirements for die-attach assembly. Its encapsulation property was improved with fewer cracks compared to similar commercial ceramic encapsulants. The die-attach material and encapsulation properties tested at 500 °C showed no defect or additional cracks. Thermal aging and thermal cycling were carried out on the samples. X-ray photo-electron spectroscopy (XPS) analysis revealed a higher oxygen bonding percentage for the 10% nanosilica ceramic sample than the samples with no nanosilica. XRD peak broadening is largest for the 10% nanosilica ceramic, which indicated smaller crystallite sizes. The smaller crystallite size for the 10% nanosilica sample introduces a larger microstrain to the alumina crystal structure. FTIR revealed the presence of alumina-silicate bonds on these samples with the largest amount present in the 10% nanosilica samples. Si-O and Al-O bonds were observed from FTIR on nanosilica samples especially the higher than 10% nanosilica samples. SEM and energy dispersive X-ray (EDX) results showed a uniform bond line for the 10% sample and uniform material distribution.
Applications and Impacts of Nanoscale Thermal Transport in Electronics Packaging
Authors: Warzoha Ronald J. , Wilson Adam A. , Donovan Brian F. , Donmezer Nazli , Giri Ashutosh , Hopkins Patrick E. , Choi Sukwon , Pahinkar Darshan , Shi Jingjing , Graham Samuel , Tian Zhiting , Ruppalt Laura 
Published: December 2020

Abstract
This review introduces relevant nanoscale thermal transport processes that impact thermal abatement in power electronics applications. Specifically, we highlight the importance of nanoscale thermal transport mechanisms at each layer in material hierarchies that make up modern electronic devices. This includes those mechanisms that impact thermal transport through: (1) substrates, (2) interfaces and two-dimensional materials, and (3) heat spreading materials. For each material layer, we provide examples of recent works that (1) demonstrate improvements in thermal performance and/or (2) improve our understanding of the relevance of nanoscale thermal transport across material junctions. We end our discussion by highlighting several additional applications that have benefited from a consideration of nanoscale thermal transport phenomena, including radio frequency (RF) electronics and neuromorphic computing.
Massive airway myiasis: an extreme rarity
Authors: Teah Ming Kai , Chu Yeen Mei , Shanmuganathan Sakuntala Dewi , Yeap Tat Boon 
Published: December 2020

Intubations are important live saving skills to maintain adequate ventilation and oxygenation. Common indications include impending upper airway obstruction, respiratory failure and impaired conscious level. Oral myiasis is an infrequently found disease which is characterised by ectoparasitic infestation of body tissues by fly maggots.We present a case report and share valuable experiences on a patient with massive airway myiasis causing upper airway obstruction which require emergency intubation.
Timing and determinants of age at menarche in low-income and middle-income countries
Authors: Leone Tiziana , Brown Laura J 
Published: December 2020

IntroductionUnderstanding the timing and determinants of age at menarche is key to determining potential linkages between onset of puberty and health outcomes from a life-course perspective. Yet, we have little information in low-income and middle-income countries (LMICs) mainly due to lack of data. The aim of this study was to analyse trends in the timing and the determinants of menarche in LMICs.MethodsUsing 16 World Fertility Survey and 28 Demographic and Health Surveys (DHS) from 27 countries, we analysed cohort trends and used fixed-effects models for DHS surveys to investigate sociodemographic and regional effects in the timing of age at menarche.ResultsTrends of the mean age at menarche across time within and between countries show a declining or stalling path. Results of the determinant modelling show the relationship with wealth changes over time although not consistently across countries. We see a shift from poorer women having earlier menarche in earlier surveys to richer women having earlier menarche in later surveys in Indonesia, the Philippines and Yemen, while in Egypt, the reverse pattern is evident.ConclusionsThere is a considerable gap in both literature and data on menarche. We see a trend which is declining rapidly (from 14.66 to 12.86 years for the 1932 and 2002 cohorts, respectively), possibly at a faster pace than high-income countries and with a strong link to socioeconomic status. This study calls for menarche questions to be included in more nationally representative surveys and greater use of existing data because of its impact on life-course health in fast-ageing settings. Further studies will need to investigate further the use of the age at menarche as an indicator of global health.
National primary care responses to COVID-19: a rapid review of the literature
Authors: Haldane Victoria , Zhang Zhitong , Abbas Raja Faisal , Dodd Warren , Lau Lincoln L , Kidd Michael R , Rouleau Katherine , Zou Guanyang , Chao Zhuo , Upshur Ross E G , Walley John , Wei Xiaolin 
Published: December 2020

ObjectiveThe aim of this review, conducted in April 2020, is to examine available national primary care guidelines for COVID-19 and to explore the ways in which these guidelines support primary care facilities in responding to the demands of the COVID-19 pandemic.DesignRapid review and narrative synthesis.Data sourcesPubMed, Embase and Google, as well as the websites of relevant national health departments, were searched from 1 January 2020 to 24 April 2020.Eligibility criteriaDocuments included must be issued by a national health authority, must be specific to COVID-19 care, directed at healthcare workers or managers, and must refer to the role of primary care in the COVID-19 response.ResultsWe identified 17 documents from 14 countries. An adapted framework on primary care challenges and responses to pandemic influenza framed our analysis. Guidelines generally reported on COVID-19 service delivery and mostly made specific recommendations for ensuring continued delivery of essential primary care services through telehealth or other virtual care modalities. Few offered guidance to support surveillance as a public health function. All offered guidance on implementing outbreak control measures, largely through flexible and coordinated organisational models with partners from various sectors. There was a lack of guidance to support supply chain management and practice resilience in primary care, and lack of personal protective equipment represents a serious threat to the provision of quality care during the pandemic.ConclusionsCurrent national primary care guidelines for COVID-19 provide guidance on infection control and minimising the risk of spread in primary care practices, while supporting the use of new technology and coordinated partnerships. However, to ensure primary care practice resilience and quality of care are upheld, guidelines must offer recommendations on supply chain management and operational continuity, supported by adequate resources.
Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan
Authors: Tseng Tzu-Jung , Yen Yun-Ting , Yang Yuan-Han , Chen Yen-Hsu , Chan Ta-Chien 
Published: December 2020

ObjectivesThis study aimed to investigate the associations between biochemical markers, renal function, health behaviours and dementia among older people.DesignA retrospective cohort study.SettingCommunity-based health examination database from Taipei city.ParticipantsIn total, 35 434 older people were included from February 2005 to December 2012. To assess changes in renal function, we selected participants who attended health examinations at least twice and responded to the AD8 questionnaire in 2012. We excluded those with dementia at baseline.Primary outcome measuresEarly dementia was assessed using the AD8 questionnaire in 2012. Explanatory variables included demographic factors, health behaviours, biochemical markers and renal function. We used a Cox proportional hazard model to estimate the HR for early dementia onset.ResultsIndividuals with mild albuminuria (HR 1.228; 95% CI 1.066 to 1.414), lower eGFR (HR 1.549; 95% CI 1.319 to 1.820) and higher age (HR 1.022; 95% CI 1.015 to 1.028) were associated with a high risk of early dementia. Older people with no alcohol intake (HR 0.872; 95% CI 0.794 to 0.958), and higher education levels (HR 0.647; 95% CI 0.589 to 0.710) were at a low risk of early dementia.ConclusionsElevated mild albuminuria and low eGFR were associated with a high risk of early dementia in this community-based cohort. Routine health examinations for older people can help screen out the high-risk population, and clinical management might reduce or delay the risk of early dementia.
Understanding ethnic inequalities in hearing health in the UK: a cross-sectional study of the link between language proficiency and performance on the Digit Triplet Test
Authors: Taylor Harry , Shryane Nick , Kapadia Dharmi , Dawes Piers , Norman Paul 
Published: December 2020

IntroductionResearch using the UK Biobank data has shown ethnic inequalities in hearing health; however, the hearing test used may exhibit a disadvantage for non-native language speakers.ObjectivesTo validate the results of the UK Biobank hearing test (Digit Triplet Test, DTT) against self-reported measures of hearing in the dataset and create classifications of hearing health. To observe if language proficiency and migration age have the same effect on hearing health classification as on the DTT in isolation. Our hypothesis is that language proficiency acts differently on the DTT, demonstrating that the DTT is biased for non-native speakers of English.DesignLatent classes representing profiles of hearing health were identified from the available hearing measures. Factors associated with class membership were tested using multinomial logistic regression models. Ethnicity was defined as (1) White, native English-speaking, (2) ethnic minority, arrived in the UK aged <12 or (3) ethnic minority, arrived aged >12.ParticipantsThe UK Biobank participants with valid hearing test results and associated covariates (N=151 268).Outcome measuresDTT score, self-reported hearing difficulty, self-reported hearing difficulty in noise and hearing aid use.ResultsThree classes of hearing health were found: ‘normal’, ‘generally poor’ and ‘only subjectively poor’. In a model adjusting for known confounders of hearing loss, a poor or insufficient hearing test result was less likely for those with better language (OR 0.69, 95% CI 0.65 to 0.74) or numerical ability (OR 0.71, 95% CI 0.67 to 0.75) but more likely for those having migrated aged >12 (OR 3.85, 95% CI 3.64 to 4.07).ConclusionsThe DTT showed evidence of bias, having greater dependence on language ability and migration age than other hearing indicators. Designers of future surveys and hearing screening applications may wish to consider the limitations of speech-in-noise tests in evaluating hearing acuity for populations that include non-native speakers.
Diagnostic accuracy of inferior vena cava ultrasound for heart failure in patients with acute dyspnoea: a systematic review and meta-analysis
Authors: Squizzato Alessandro , Maroni Lorenzo , Marrazzo Cristina , Riva Nicoletta , Guasti Luigina 
Published: December 2020

BackgroundDyspnoea is the most common sign of heart failure (HF). Patients accessing the ED for HF-related symptoms require fast diagnosis and early treatment. Transthoracic echocardiography has a crucial role in HF diagnosis, but requires qualified staff and adequate time for execution. The measurement of inferior vena cava (IVC) diameter has been recently proposed as a rapid, simple and reliable marker of volume overload. The aim of this systematic review was to assess the accuracy of IVC-ultrasound as a stand-alone test for HF diagnosis in patients presenting to the ED with acute dyspnoea.MethodsStudies evaluating the diagnostic accuracy of the inferior vena cava collapsibility index (IVC-CIx) for HF diagnosis were systematically searched in the EMBASE and MEDLINE databases (up to January 2018). Quality Assessment of Diagnostic Accuracy Studies 2 tool was used for the quality assessment of the primary studies. A bivariate random-effects regression approach was used for summary estimates of both sensitivity and specificity.ResultsSeven studies, for a total of 591 patients, were included. Three studies were at low-risk of bias. All studies used a proper reference test. Weighted mean prevalence of HF was 49.3% at random-effect model (I2index for heterogeneity=74.7%). IVC-CIx bivariate weighted mean sensitivity was 79.1% (95% CI 68.5% to 86.8%) and bivariate weighted mean specificity was 81.8% (95% CI 75.0% to 87.0%).ConclusionsOur findings suggest that the sensitivity and specificity of IVC-CIx are suboptimal to rule in or rule out HF diagnosis in patients with acute dyspnoea in the ED setting. Therefore, IVC-CIx is not advisable as a stand-alone test, but may be useful when integrated in a specific diagnostic algorithm for the differential diagnosis of acute dyspnoea.
Patients’ and health professionals’ perceptions of the LoDED (limit of detection and ECG discharge) strategy for low-risk chest pain management: a qualitative study
Authors: Beasant Lucy , Carlton Edward , Williams Gareth , Benger Jonathan , Ingram Jenny 
Published: December 2020

BackgroundRapid discharge strategies for patients with low-risk chest pain using high-sensitivity troponin assays have been extensively evaluated. The adherence to, and acceptability of such strategies, has largely been explored using quantitative data. The aims of this integrated qualitative study were to explore the acceptability of the limit of detection and ECG discharge strategy (LoDED) to patients and health professionals, and to refine a discharge information leaflet for patients with low-risk chest pain.MethodsPatients with low-risk chest pain who consented to a semi-structured interview were purposively sampled for maximum variation from four of the participating National Health Service sites between October 2018 and May 2019. Two focus groups with ED health professionals at two of the participating sites were completed in April and June 2019.ResultsA discharge strategy based on a single undetectable hs-cTn test (LoDED) was acceptable to patients. They trusted the health professionals who were treating them and felt reassured by other tests, (ECG) alongside blood test(s), even when the clinical assessment did not provide a firm diagnosis. In contrast, health professionals had reservations about the LoDED strategy, including concern about identifying low-risk patients and a shortened patient observation period. Findings from 11 patient interviews and 2 staff focus groups (with 20 clinicians) centred around three overarching themes: acceptability of the LoDED strategy, perceptions of symptom severity and uncertainty, and patient discharge information.ConclusionRapid discharge for low-risk chest pain is acceptable to patients, but clinicians reported some reticence in implementing the LoDED strategy. Further work is required to optimise discharge discussions and information provision for patients.
Investigating microsized anthropogenic particles in Norwegian fjords using opportunistic nondisruptive sampling
Authors: Nerheim Magnus S. , Lusher Amy L. 
Published: December 2020

Abstract
Norwegian fjord systems provide a host of ecosystem services and are important for recreational and industrial use. The biodiversity of Norwegian fjords has been—and still is—extensively studied since they are important for fishing and aquaculture industries. However, threats from plastic and microplastic pollution within the fjord systems are largely undocumented. Monitoring efforts of microplastic in Norway are limited to coastal biota monitoring, offshore sediments, and some investigations within Oslofjord. Here, we quantify anthropogenic microparticles in Norwegian fjord subsurface waters, including an analysis of distribution effects. Fifty-two samples were collected during repeated transits from Bergen to Masfjorden covering 250 km. Anthropogenic particles were identified in 89% of samples, with an average abundance within the fjord estimated to be 1.9 particles m−3. This report shows the ubiquitous nature of anthropogenic particles in the subsurface waters of a Norwegian Fjord system. Additionally, methods were validated for opportunistic nondisruptive sampling on-board vessels where microplastics are seldom monitored, including research vessels, commercial freight and transport, and recreational vessels. Further development and implementation of these methods in terms of sampling, chemical characterisation, and long-term monitoring will allow for microplastic quantification and can be easily adapted for worldwide implementation.
Effect of dietary inclusion ofAchyranthes japonicaextract on growth performance, fecal microbiota, fecal gas emission, nutrient digestibility, and meat-carcass grade quality traits in finishing pigs
Authors: Mohankumar Thamaraikannan , Kim Yong Min , Kim In Ho 
Published: December 2020

A 10 wk experimental trial was carried out to determine the effect of dietary inclusion of Achyranthes japonica extract (AJE) on finishing pigs’ overall performance. A total of 150 finishing pigs with initial body weight (BW) of 54.17 ± 2.27 kg were randomly allocated to five dietary treatments. The dietary treatments were CON (basal diet), TRT1 (basal diet + 0.025% AJE), TRT2 (basal diet + 0.05% AJE), TRT3 (basal diet + 0.1% AJE), and TRT4 (basal diet + 0.2% AJE). Dietary AJE supplementation linearly increased BW, average daily gain (ADG), and gain to feed ratio (G/F) during week 5. At week 10 and overall experiment, there was tendency for linear increase in BW, ADG, and average daily feed intake. Dietary supplementation of AJE failed to show significant effects on nutrient digestibility, fecal microbiota, meat quality, and fecal gas emission. The dietary supplementation of AJE showed a linear increase in the backfat thickness (BFT) at week 10, and there was no significant difference observed on the lean meat percentage. In summary, AJE supplementation had a beneficial effect on the growth performance, BFT, and also no effects on nutrient digestibility and fecal microbiota of the finishing pigs.
ArborX
Authors: Lebrun-Grandié D. , Prokopenko A. , Turcksin B. , Slattery S. R. 
Published: December 2020

Searching for geometric objects that are close in space is a fundamental component of many applications. The performance of search algorithms comes to the forefront as the size of a problem increases both in terms of total object count as well as in the total number of search queries performed. Scientific applications requiring modern leadership-class supercomputers also pose an additional requirement of performance portability, i.e., being able to efficiently utilize a variety of hardware architectures. In this article, we introduce a new open-source C++ search library, ArborX, which we have designed for modern supercomputing architectures. We examine scalable search algorithms with a focus on performance, including a highly efficient parallel bounding volume hierarchy implementation, and propose a flexible interface making it easy to integrate with existing applications. We demonstrate the performance portability of ArborX on multi-core CPUs and GPUs and compare it to the state-of-the-art libraries such as Boost.Geometry.Index and nanoflann.
The Prognosis Role of AST/ALT (De Ritis) Ratio in Patients with Adult Secondary Hemophagocytic Lymphohistiocytosis
Authors: Yin Guangli , Man Changfeng , Liao Shengen , Qiu Hongxia 
Published: December 2020

Purpose. Secondary hemophagocytic lymphohistiocytosis (sHLH) accompanied by liver involvement, characterized by hepatomegaly and increased liver enzymes, is usually associated with elevated mortality. However, the magnitude of these associations remains unknown. Our objective was to assess the associations of the aspartate transaminase/alanine transaminase (AST/ALT, De Ritis) ratio with overall survival among adult patients with sHLH. Methods. A retrospective analysis was performed on 289 patients aged 18–86 years with complete serum transaminase data at diagnosis of sHLH. Multivariate Cox regression analyses and restricted cubic splines were conducted to address the association between the De Ritis ratio and the risk of mortality. Results. The median De Ritis ratio for the entire study population was 1.34 (IQR: 0.84-2.29). After a median follow-up time of 60 (range 17-227.5) days, 205 deaths occurred. After fully adjusting for hepatomegaly, albumin, fibrinogen, EBV, ferritin, etiologies, and treatment strategies, the adjusted hazard ratios (HRs) with corresponding confidence intervals (CIs) of mortality for the 2 st tertile and 3 st tertile were 1.2 (0.8-1.7) and 1.6 (1.1-2.2), respectively (

P
<
0.01

for trends). Restricted cubic spline confirmed a linear association between the log2-transformed De Ritis ratio and the risk of mortality. Moreover, this trend persisted in subgroups with MHLH, hyperferrinaemia,

sCD
25
≤
20,000

ng
/
L

, patients without EBV infection, and those received treatment. Conclusions. The De Ritis ratio is a strong and independent predictor for overall survival in patients with sHLH. As a readily available biomarker in routine clinical practice, it is used to identify patients with sHLH with inferior overall survival.