bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative model of self‐determination and related contextual variables in adolescents with and without disabilities
Authors: Mumbardó‐Adam Cristina , Guàrdia‐Olmos Joan , Giné Giné Climent 
Published: January 2020

AbstractSelf‐determination, as a person dispositional characteristic, is indeed influenced by situational characteristics that shape actions across contexts. Research has also reported differences in self‐determination as a function of personal factors, but there is a need to integrate this knowledge in a general model aiming to analyse the impact of contextual variables in adolescents with and without disabilities. An integrative model of self‐determination and related contextual factors was tested through a structural equation modelling approach. Participants were adolescents that reported their perceptions on self‐determination dimensions and opportunities. Results indicated that educational and family contexts impacted self‐determination and provided further understanding on self‐determination dimensions’ entity and function. Relevant implications for self‐determination measure, comprehension and promotion derived from this study are discussed.
Use of a clot aspiration system during transvenous lead extraction
Authors: Richardson Travis D. , Lugo Ricardo M. , Crossley George H. , Ellis Christopher R. 
Published: January 2020

AbstractIntroductionThe optimal approach to the extraction of leads with large vegetations remains uncertain.MethodsHigh‐risk patients with lead associated vegetations undergoing device extraction at Vanderbilt Hospital with concomitant use of the Penumbra Aspiration System (Penumbra Inc, Alameda, CA) are described. An 8.5 Fr Agilis NXT (Abbott Inc, St. Paul, MN) was advanced to the right atrium, through which a Penumbra Indigo Cat‐8 catheter was advanced. Using intracardiac echocardiography, the Penumbra was positioned directly on the vegetation, suction was applied until adherent, and the Indigo catheter and Agilis sheath were then removed en‐bloc and aspirated debris flushed out. This was repeated until debulking was considered successful.ResultsEight cases were performed. The median vegetation size was 2 cm. Pathogens were Enterococcus, Staphylococcus, Candida, Cutibacterium, and Enterobacter. In seven of eight cases, aspiration successfully reduced vegetations to less than 1 cm before successful percutaneous cardiac implantable electronic device removal. One patient underwent surgical removal via thoracotomy. There were no acute complications related to the Penumbra catheter. Three patients had CT evidence of small pulmonary emboli postprocedure. The length of stay was 3 to 27 days. One patient died on POD 1 of refractory ventricular tachycardia unrelated to the procedure. One patient died of ongoing sepsis 2 weeks postextraction.ConclusionsThe Penumbra Indigo Aspiration system can be useful for vegetation debulking before transvenous lead extraction.
Prognostic significance of the renal resistive index in the primary prevention of type II diabetes
Authors: Delsart Pascal , Vambergue Anne , Ninni Sandro , Machuron François , Lelievre Bénédicte , Ledieu Guillaume , Fontaine Pierre , Merlen Emilie , Frimat Marie , Glowacki François , Montaigne David , Mounier‐Vehier Claire 
Published: January 2020

AbstractThe renal resistive index has been demonstrated to predict the progression of renal disease and recurrence of major cardiac events in high‐risk cardiovascular patients, in addition to other comorbidities. We aimed to assess the prognostic significance of the renal resistive index in type 2 diabetic patients for primary prevention. From 2008 to 2011, patients with type 2 diabetes underwent cardiovascular evaluation, including renal resistive index assessment by renal Doppler ultrasound. The incidence of all‐cause death, cardiovascular events, dialysis requirement or a twofold increase in creatinine was recorded. Survival curves were estimated by the Kaplan‐Meier method. Two hundred sixty‐six patients were included; 50% of the patients were men, an HbA1C level of 8.1 ± 1.7% (65 ± 13.6 mmol/mol) and a serum creatinine level of 8 [7‐9] mg/L. The mean 24‐hour systolic blood pressure, 24‐hour diastolic blood pressure, and 24‐hour pulse pressure were 133.4 ± 16.7, 76.5 ± 9.4, and 56.9 ± 12.4 mm Hg, respectively. The median renal resistive index was 0.7 [0.6‐0.7] with a threshold of 0.7 predictive of monitored events. After adjustment of the 24‐hour pulse pressure, age and 24‐hour heart rate, a renal resistive index ≥0.70 remained associated with all‐cause death (hazard ratio: 3.23 (1.16‐8.98); P = .025) and the composite endpoint of major clinical events (hazard ratio: 2.37 (1.34‐4.18); P = .003). An elevated renal resistive index with a threshold of 0.7 is an independent predictor of a first cardiovascular or renal event in type 2 diabetic patients. This simple index should be implemented in the multiparametric staging of diabetes.
Research update on the association between SFRP5, an anti‐inflammatory adipokine, with obesity, type 2 diabetes mellitus and coronary heart disease
Authors: Wang Di , Zhang Yaping , Shen Chengxing 
Published: January 2020

AbstractSecreted frizzled‐related protein 5 (SFRP5), an anti‐inflammatory adipokine secreted by adipocytes, has been demonstrated to exert its anti‐inflammatory effect via antagonizing the non‐canonical wingless‐type family member 5A (WNT5A) signalling pathways. The WNT5A protein, as a potent pro‐inflammatory signalling molecule, is strongly involved in a variety of inflammatory disorders such as obesity, type 2 diabetes mellitus (T2DM) and atherosclerosis. In this review, we systematically outlined the current understanding on the roles of SFRP5 in the pathogenesis of three inflammatory diseases including obesity, T2DM and coronary heart disease (CHD). Our review might stimulate future research using SFRP5 as a promising novel therapeutic target for the treatment of obesity, T2DM and CHD.
Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000‐2015: a retrospective multicentre study
Authors: Dickel H. , Kuhlmann L. , Bauer A. , Bircher A.J. , Breuer K. , Fuchs T. , Grabbe J. , Mahler V. , Pföhler C. , Przybilla B. , Rieker‐Schwienbacher J. , Schröder‐Kraft C. , Simon D. , Treudler R. , Weisshaar E. , Worm M. , Trinder E. , Geier J. 
Published: January 2020

AbstractBackgroundThe diagnostic significance of the atopy patch test for the management of dermatitis possibly triggered by aeroallergens is still controversial. However, sufficiently large studies with routinely tested standardized aeroallergen patch test preparations in dermatitis patients are lacking.ObjectiveTo evaluate the reaction frequency and the reaction profiles of 10 until mid‐2015 commercially available, standardized aeroallergen patch test preparations of the ‘Stallerpatch’ test series (Stallergenes, Antony Cedex, France) in a large multicentre patient cohort.MethodsA retrospective data analysis of patients with suspected aeroallergen‐dependent eczematous skin lesions was performed, who were patch tested in 15 Information Network of Departments of Dermatology‐associated clinics between 2000 and 2015. Patients were stratified according to their atopic dermatitis (AD) status.ResultsThe study group included 3676 patients (median age 41 years, 34.8% males, 54.5% AD). The most common aeroallergens causing positive patch test reactions were Dermatophagoides pteronyssinus (19.6%), Dermatophagoides farinae (16.9%), birch (6.2%), timothy grass (6.0%), cat dander (5.4%), mugwort (4.9%) and dog dander (4.6%). Reactions to other pollen allergen preparations, that is 5 grasses (3.2%), cocksfoot (2.1%) and plantain (1.6%), were less common. Positive patch test reactions to aeroallergens were consistently more frequent in patients with AD. These patients showed proportionally less dubious, follicular, irritant and weak positive reactions. Independent of AD status, a patient history of past or present allergic rhinitis was associated with an increased chance of a positive aeroallergen patch test reaction to pollen allergens.ConclusionThe aeroallergen patch test is a useful add‐on tool in clinical routine, especially in patients with AD and/or respiratory allergy. A patch test series comprising Dermatophagoides pteronyssinus, Dermatophagoides farinae, birch, timothy grass, cat dander and mugwort seems to be suitable. Controlled studies with specific provocation and elimination procedures are required to further evaluate the diagnostic significance of the proposed screening series.
Factors associated with diagnostic accuracy, technical success and adverse events of endoscopic ultrasound‐guided fine‐needle biopsy: A systematic review and meta‐analysis
Authors: Li De‐Feng , Wang Jian‐yao , Yang Mei‐feng , Xiong Feng , Zhang Ding‐guo , Xu Zheng‐lei , Luo Min‐Han , Jing Zhen‐dong , Wang Kai‐Xuan , Wang Li‐sheng , Yao Jun 
Published: January 2020

AbstractBackground and AimEndoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) is used to diagnose lesions within or adjacent to the digestive tract. However, there is no report on the overall diagnostic accuracy, technical success, and adverse events of FNB. The aims of this study were to conduct a systematic review and meta‐analysis to comprehensively assess the diagnostic accuracy, technical success, and adverse events of FNB.MethodsPubmed, Embase, and Cochrane Library databases were searched for relevant articles published in English from January 1998 to May 2019 (No. CRD42019141647). Primary outcomes were EUS‐FNB related diagnostic accuracy rate, technical success rate, and adverse event rate.ResultsA total of 51 articles including 5330 patients met our criteria. The overall EUS‐FNB related diagnostic accuracy rate, technical success rate, and adverse event rate was 90.82% [95% confidence interval (CI) 88.69–92.76%], 99.71% [95% CI 99.35–99.93%], and 0.59% [95% CI 0.29–1.0%], respectively. Biopsy with 22G needle could increase the diagnostic accuracy rate and technical success rate to 92.17% [95% CI 89.32–94.61%] and 99.88% [95% CI 99.64–99.99%], respectively, and decrease the adverse event to 0.37% [95% CI 0.08–0.87%]. Moreover, it showed that 22G needle was an independent factor associated with a higher diagnostic accuracy rate and technical success rate and a lower adverse event rate (P = 0.04, P < 0.001, and P = 0.04, respectively) by univariate and multivariate meta‐regression analyses.ConclusionEndoscopic ultrasound‐guided fine‐needle biopsy is a feasible and safe procedure for lesions within or adjacent to the digestive tract. Biopsy using 22G needle could increase the diagnostic accuracy rate and technical success rate and decrease adverse event rate during the FNB procedure.
Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage
Authors: Sajjadi Maryam S. , Ghandil Pegah , Shahbazian Nahid , Saberi Alihossein 
Published: January 2020

AbstractAimIdiopathic recurrent spontaneous miscarriage (IRSM) is one of the pregnancy outcomes that affects 1–2% of women trying to conceive. Specific genotype or aberrant expression of vascular endothelial growth factor A (VEGFA) and connexin 43 (Cx43) as two important genes for embryonic development are deemed to increase the risk of IRSM.MethodsTo investigate any possible association of VEGFA polymorphisms and aberrant expression of Cx43 and VEGFA with IRSM, we carried out a case–control study including embryo chorionic villus tissues of 100 pregnant women with IRSM and 100 embryo chorionic villus tissues of healthy pregnant women without history of miscarriage. Restriction fragment length polymorphism was used for genotyping of rs699947 (−2578C/A) and rs2010963 (−634G/C) polymorphisms in VEGFA. Besides, quantitative real‐time PCR was performed for VEGFA and Cx43 expression analysis.ResultsThe results showed that the frequency of −634G/C and C/C genotypes was significantly higher in aborted fetuses (P = 0.001 and P < 0.001, respectively) compared to the control group's. However, the frequency of −2578C/A genotypes was not significantly different between the cases and controls. Moreover, a significant higher expression of VEGF (P = 0.0005) and Cx43 (P = 0.0011) was observed in chorionic villus tissues of women with IRSM.ConclusionThe finding demonstrated that IRSM frequency may depend on GC and CC genotypes of rs2010963 VEGF polymorphism and expression level of VEGF and Cx43 in IRSM patients was increased.
Effect of endometrial injury during menstruation on clinical outcomes in frozen–thawed embryo transfer cycles: A randomized control trial
Authors: Tang Zhixia , Hong Mingyun , He Fang , Huang Dayan , Dai Zhijun , Xuan Henghua , Zhang Hong , Zhu Weipei 
Published: January 2020

AbstractAimTo explore the clinical effect of endometrial injury (EI) on the third day of the menstrual cycle before frozen–thawed embryo transfer (frozen–thawed ET) on patients experienced two or more implantation failures.MethodsA total of 200 patients who suffered at least two failed hormone‐replacement therapies and frozen–thawed ET were randomly divided into two groups: EI group and control group (n = 100 in each group). Patients in the EI group received local EI with a Pipelle catheter on the third day of the menstrual cycle before frozen–thawed ET. Primary outcomes were live birth, clinical pregnancy and implantation rates. Secondary outcomes were biochemical, multiple and ectopic pregnancy rates and abortion rates.ResultsThe rate of live birth in EI group (51.00%) was significantly higher than that of control group (36.00%) (P = 0.032). Clinical pregnancy and implantation rates in EI group were significantly higher comparing to control group (64.00% vs 48.00%, P = 0.023 and 46.74% vs 30.11%, P = 0.001). The rate of multiple pregnancy in EI group (37.50%) was significantly higher than that of control group (18.75%) (P = 0.031). No significant difference in ectopic pregnancy rate and abortion rate was observed between EI group and control group.ConclusionApplying EI to patients experienced two or more implantation failures on the third day of the menstrual cycle before frozen–thawed ET can improve clinical outcomes.
People, Actors, and the Humanizing of Institutional Theory
Authors: Voronov Maxim , Weber Klaus 
Published: January 2020

AbstractIn much contemporary institutional scholarship, the term ‘actor’ is used as a shorthand for any entity imbued with agency. Talking about actors in institutions thus serves the necessity of allocating agency before returning to the analysis of institutional structures and processes. We find this approach to actorhood limiting, conceptually and normatively. Grounded in the perspective of pragmatist phenomenology, we assert the need for distinguishing between persons and actors, and the value of integrating the person into institutional analysis. We conceive of persons as humans with a reflective capacity and sense of self, who engage with multiple institutions through the performance of institutional roles. People may acquire actorhood by temporarily aligning their self with what is expected from a particular actor‐role in an institutional order. Conversely, institutions enter people’s lifeworld as they are personified in people’s social performances. We outline this perspective and examine conceptual and normative implications that arise from the integration of human experience in institutional analysis.
Institutions and Actorhood as Co‐Constitutive and Co‐Constructed: The Argument and Areas for Future Research
Authors: Meyer Renate E. , Vaara Eero 
Published: January 2020

AbstractWe argue that in order to overcome the reductionism and essentialism in institutional theory there is a need to acknowledge that institutions and social actors are co‐constitutive and co‐constructed in processes of communication. We elaborate this argument by drawing on the phenomenological foundation of institutional theory and point to promising areas of future research: the multimodal nature of institutions, the mediated and mediatized character of modern communication, and the contestedness of all social orders and their legitimation.
Determination of the lingual border of lower complete dentures: How to use a silicone impression material?
Authors: Yamazaki Fumiaki , Mihara Yusuke , Maeda Yoshinobu , Matsuda Ken‐ichi , Mameno Tomoaki , Ikebe Kazunori 
Published: January 2020

AbstractObjectivesThis study aimed to clarify the efficacy of a border‐moulding procedure with low‐flow silicone impression material compared with a conventional compound to complete denture fabrication. It also aimed to evaluate the influence of various functional tasks during the lingual‐side moulding procedure regarding the depth and width of the border.MethodsTen dentate subjects (three men, seven women; average age 30 years) were enrolled in this study after giving informed consent. A specially designed custom impression tray for the mandibular lingual side was fabricated for each subject. With the tray and heavy‐body‐type silicone material, lingual border moulding was performed that included four functional tasks: tongue protrusion (TP), licking the upper lip with the tongue (UL), swallowing (SW), and placing the tongue tip to the palate (PP).ResultsWithin the limitations of this study, the results suggested that heavy‐body silicone impression material is satisfactory for use in the border‐moulding procedure, giving reproducible results.ConclusionThere were no significant differences among the functional tasks regarding the depth and width of the lingual flange except for swallowing, which exhibited the largest values.
RP11‐874J12.4 promotes oral squamous cell carcinoma tumorigenesis via the miR‐19a‐5p/EBF1 axis
Authors: Liu Guo‐Min , Lu Tian‐Cheng , Sun Mao‐Lei , Ji Xuan , Zhao Yi‐An , Jia Wen‐Yuan , Luo Yun‐Gang 
Published: January 2020

AbstractBackgroundOral squamous cell carcinoma (OSCC) ranks as the fifth most frequent cancer worldwide, and the recurrence and migration of OSCC still pose large threats to patients. Long non‐coding RNAs (lncRNAs) have recently emerged as crucial players in cancer development, and it is of great significance to understand the regulatory nexus of lncRNAs in OSCC.MethodsHere, we identified a novel lncRNA, RP11‐874J12.4, which is ectopically expressed in OSCC and facilitates OSCC.ResultsRP11‐874J12.4 directly binds to and regulates miR‐19a‐5p. Interestingly, RP11‐874J12.4 and miR‐19a‐5p form a negative regulatory loop that inhibits the expression of miR‐19a‐5p in OSCC. The expression of an oncogenic transcription factor, EBF1, is unleashed in OSCC due to the low expression of miR‐19a‐5p, which promotes the growth and migration of OSCC.ConclusionOur data illustrate a regulatory axis of RP11‐874J12.4/miR‐19a‐5P/EBF1 and an inhibitory loop with RP11‐874J12.4 and miR‐19a‐5p. These data provide insights into the tumorigenesis of OSCC and the novel drug targets for OSCC.
Dimensions of Religion and Spirituality: A Longitudinal Topic Modeling Approach
Authors: Kim Seong‐Hyeon , Lee Narae , King Pamela Ebstyne 
Published: January 2020

AbstractIn lieu of the traditional text data analysis methods, structural topic modeling was utilized to analyze the text contents of 255 self‐report inventories of religion and spirituality (R/S) published from 1929 to 2017. The study had two objectives: (a) to clarify and identify the latent dimensions of R/S inherent in the items of the measures; and (b) to examine and demonstrate the usefulness of a longitudinal topic modeling in the study of R/S. We identified 5,617 unique text terms from the measures and fitted topic models on those terms to extract latent dimensions called topics. We also simultaneously analyzed the longitudinal effect of publication decade (i.e., 1950s–2010s) on the topics. A topic model with three topics was chosen to best support the data: Experience of Transcendence (Topic 1), Engagement in Transcendence (Topic 2), and Essence of Transcendence (Topic 3). In addition, the longitudinal analysis revealed that Topic 1 showed a continual increase over the decades, while Topics 2 and 3 both demonstrated a gradual decrease, in effect matching the general trend of Topic 1's increasing popularity in society and the academia.
Thoracolumbar meningeal fibrosis in pugs
Authors: Rohdin Cecilia , Ljungvall Ingrid , Häggström Jens , Leijon Alexandra , Lindblad‐Toh Kerstin , Matiasek Kaspar , Rosati Marco , Wohlsein Peter , Jäderlund Karin Hultin 
Published: January 2020

AbstractBackgroundThoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs.ObjectivesTo further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy.AnimalsThirty client‐owned pure‐bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study.MethodsProspective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death.ResultsTwenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66‐96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho‐histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs.Conclusions and Clinical ImportanceMeningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long‐standing thoracolumbar myelopathy.
Conifers exhibit a characteristic inactivation of auxin to maintain tissue homeostasis
Authors: Brunoni Federica , Collani Silvio , Casanova‐Sáez Rubén , Šimura Jan , Karady Michal , Schmid Markus , Ljung Karin , Bellini Catherine 
Published: January 2020

Summary

Dynamic regulation of the concentration of the natural auxin (IAA) is essential to coordinate most of the physiological and developmental processes and responses to environmental changes. Oxidation of IAA is a major pathway to control auxin concentrations in angiosperms and, along with IAA conjugation, to respond to perturbation of IAA homeostasis. However, these regulatory mechanisms remain poorly investigated in conifers. To reduce this knowledge gap, we investigated the different contributions of the IAA inactivation pathways in conifers.
MS‐based quantification of IAA metabolites under steady‐state conditions and after perturbation was investigated to evaluate IAA homeostasis in conifers. Putative Picea abies GH3 genes (PaGH3) were identified based on a comprehensive phylogenetic analysis including angiosperms and basal land plants. Auxin‐inducible PaGH3 genes were identified by expression analysis and their IAA‐conjugating activity was explored.
Compared to Arabidopsis, oxidative and conjugative pathways differentially contribute to reduce IAA concentrations in conifers. We demonstrated that the oxidation pathway plays a marginal role in controlling IAA homeostasis in spruce. By contrast, an excess of IAA rapidly activates GH3‐mediated irreversible conjugation pathways.
Taken together, these data indicate that a diversification of IAA inactivation mechanisms evolved specifically in conifers.