bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant Hormone in Bean Cultivation Applied in Seed Treatment
Authors: Vilela Breno Rossi Correia , Almeida Júnior Joaquim Júlio de , Smiljanic Katya Bonfim Ataides , Matos Francisco Solano Araújo , Melo Junior Jair Pereira de , Miranda Beatriz Campos , Silva Victor Júlio Almeida , Silva Luis Filipe Almeida , Oliveira Danilo Marques , Garcia Emília da Costa 
Published: December 2024

Objective: The objective was to investigate different doses of hormone in the spray drier formulation for seed treatment in the bean crop, conducted in the Midwest region. The crop planted was the bean cultivar BRS STILO.

Theoretical Framework: Corn is one of the most important food and energy crops, not only in Brazil, of course, but throughout the world. The new paradigm of agricultural management, including amino acids, micronutrients and beneficial fungi and bacteria, is gaining more and more attention with the need to develop sustainable, yet more productive agriculture. Such practices involve not only correction, but also soil nutrition, together with the strengthening of plant metabolism to increase production efficiency and reduce dependence on chemical inputs.

Method: The methodology adopted for this research comprises a field research of a scientific nature, with a quantitative approach.

Results and Discussion: The product used in the spray drier formulation met the needs of the bean crop for the BRS STILO cultivar in all its tested variables, improving crop development in several aspects, mainly in productivity.

Research Implications: The practical implications of this research are discussed, providing practical parameters for how the results can be applied in the field with returns to the rural producer.

Originality/Value: This study contributes to the academic environment by highlighting the originality of the research, whether through an innovative approach, new methodologies and/or practical use. The relevance and value of this research are evidenced by the need for more research in this area with sustainable practices.
Comparing the Hippocampal Volume Between Patients with Alzheimer’s Disease and Healthy Controls: An MRI Analysis using the Harmonized Hippocampal Protocol
Authors: Nguyen Hai Dac , Huynh Tri , Nguyen My , Nguyen Ha , Bui Luan Cong , Ta Tri Minh , Nguyen Hai , Ha Huong 
Published: December 2024

Objective: To compare the hippocampal volume between individuals with normal cognitive function (CN) and those with Alzheimer’s disease (AD) using the European Alzheimer’s Disease Consortium (EADC)-Alzheimer’s Disease Neuroimaging Initiative (ADNI) Harmonized Hippocampal Protocol (HarP). Methods: This retrospective study included 84 participants (42 individuals each in the AD and CN groups) from April 30th Hospital (Ho Chi Minh City, Vietnam). The AD diagnosis adhered to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Participants underwent neuropsychological tests and whole brain magnetic resonance scans for cognitive function and hippocampal volume assessments. The AD participants were categorized into four subgroups based on the severity of their cognitive decline, determined using the Mini-Mental State Examination scores (AD1: 5=24, AD2: 20-23, AD3: 14-19, and AD4: 0-13). Qualified radiologists used HarP to measure the whole and sectional hippocampal volumes. Statistical analyses were performed to compare the hippocampal volume differences between the AD and CN groups considering disease severity, sex, and age. A multifactor regression analysis was conducted to explore the predictive factors for hippocampal volume. Results: The neuropsychological test findings (p-value < 0.001), but not demographic data (sex, education, body mass index, medical history), were significantly different among the AD subgroups. The whole (AD: 4.158 ± 0.989 cm3; CN: 5.884 ± 0.517 cm3) and sectional hippocampal volumes were significantly different between the AD and CN groups (p-value < 0.0001). Specifically, the whole and sectional hippocampal volumes were significantly different between the AD2 subgroup and CN group (p-value < 0.05). Besides, multifactor regression analysis showed a minimal impact of the demographic factors on the whole hippocampal volume. Conclusion: Our study highlights the association between AD and reduced hippocampal volume, emphasizing its significance in the disease’s pathology. Our data support the effectiveness of the HarP in measuring hippocampal volume.
Sosialisasi Olahraga Tenis Meja Terhadap Pembibitan Atlet Muda di Desa Warulor
Authors: Royana Ibnu Fatkhu , Kresnapati Pandu , Setyawan Danang Aji , Setiawan David Firna 
Published: December 2024

Kekurangan pendampingan dari orang dewasa dapat menjadikan anak malas berolahraga dan lebih disibukkan dengan gadget. Permasalahan anak-anak di Desa Waruloor, Kecamatan Wiradesa Kabupaten Pekalongan adalah tingkat ketergantungan gadget yang tinggi, kurangnya pembinaan prestasi atlet di usia muda terutama cabang tenis meja. Solusi yang ditawarkan mitra adalah dengan melengkapi sarana prasaraa dan melakukan pendampingan pelatihan selama 3 bulan. Metode pengabdian yang digunakan adalah service learning. Jumlah sampel dalam pengabdian ini berjumlah 28 anak. Hasil dari pengabdian ini tingkat minat anak dalam bermain tenis meja rata-rata tergolong tinggi dengan jumlah 64,3% tinggi, 25% sangat tinggi dan 10,7% kategori cukup. Sedangkan selama 3 bulan pendampingan jumlah rata-rata kehadiran anak dalam berlatih tenis meja adalah 88,4%. Kesimpulan dari pendampingan ini tingkat olahraga anak-anak menjadi meningkat dan dapat dijadikann pembibitan atlet baru dalam cabang olahraga tenis meja.
Comparison of the magnetic resonance elastography and FIB-4 (MEFIB) Index and vibration-controlled transient elastography for significant metabolic dysfunction–associated steatotic liver disease fibrosis
Authors: Bera Chinmay , Fakhriyehasl Mina , Hamdan Perez Nashla , Kosick Heather Mary-Kathleen , Patel Keyur , Jhaveri Kartik 
Published: December 2024

Background: Significant fibrosis (≥stage 2) in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) is considered a high risk for morbidity and mortality. The magnetic resonance elastography (MRE) and FIB-4 (MEFIB) Index (MRE ≥ 3.3 kPa and FIB-4 ≥ 1.6) has been proposed as an alternative to liver biopsy, particularly in identifying patients for therapeutic intervention. However, MRE is not widely available. Our aim was to compare the MEFIB Index with other simpler, non-invasive markers. Methods: A single-centre retrospective analysis of steatotic liver disease patients with MRE and vibration-controlled transient elastography (VCTE) was carried out between March 2019 and June 2022. Demographic and laboratory data were collected to calculate various fibrosis scores. Results: Our cohort included 77 patients with a mean ± SD age of 51 ± 13 years, 44/77 (57%) female, BMI 34.5 ± 6.7 kg/m2, and 33/77 (43%) with diabetes mellitus. Significant MEFIB Index fibrosis (F2–4) compared with F0–1 was significantly associated with older age (61.6 versus 48.9 years), higher VCTE score (18.2 versus 10.6 kPa), NAFLD Fibrosis Score (0.11 versus -1.68), and Aspartate Aminotransferase-To-Platelet Ratio Index (APRI; 1.43 versus 0.44). A logistic regression model showed that age (odds ratio [OR]: 1.16; 95% CI: 1.05–1.29; p = 0.005) and APRI (OR: 10.86; 95% CI: 1.56–75.68; p = 0.016) were independently associated with MEFIB Index and predicted MEFIB F ≥ 2 with an area under the receiver operating characteristic curve of 0.95 (95% CI: 0.87–0.98). Conclusions: In patients with MASLD, simple clinical and biochemical parameters may provide an alternative to predict significant fibrosis based on the MEFIB score. This may be useful in non-tertiary centres where VCTE and MRE are not routinely available.
Canadian Public Health Laboratory Network (CPHLN) diagnostic recommendations for neurosyphilis in Canada
Authors: Wudel Bev , Purewal Rupeena , Hatchette Todd F , Stein Derek , Morshed Muhammad , Minion Jessica , Vallée Maud , Hayden Kristy , Hamula Camille 
Published: December 2024

Eight provinces and territories are currently experiencing syphilis outbreaks in Canada, with the national rate of infectious syphilis increasing significantly from 5.1 per 100,000 population in 2011 to 36.1 per 100,000 population in 2022. Neurosyphilis refers to infection of the central nervous system by Treponema pallidum, which may occur at any stage. It is to be expected that along with the syphilis outbreak, a concomitant rise in neurosyphilis cases will occur. It is important to note that Canadian national surveillance data on neurosyphilis is not currently published as it is inconsistently reported and often lumped in with secondary and tertiary syphilis rates. Future surveillance efforts must focus on properly identifying these cases to quantify the scope of the problem. This article summarizes Canadian Public Health Laboratory Network guidelines for neurosyphilis diagnosis.
Adaptation and Validation of an Evaluation Instrument for Student Assessment of Veterinary Clinical Teaching
Authors: Gordon-Ross Paul N. , Gloeckner Gene W. , West Andrew B. , Diniz Pedro P. V. P. , Levi Ohad , Eng Curtis L. , Barr Margaret C. 
Published: December 2024

There is a dearth of validated instruments for assessing clinical teaching in veterinary education. This study describes the development and validation of a veterinary-adapted Stanford Faculty Development Program 26 (SFDP-Vet22) instrument for student evaluation of veterinary clinical educators. Validity evidence was gathered in three specific categories: (a) content, (b) response process, and (c) internal structure. Content validity was supported by the educational theory and research underlying the Stanford Faculty Development Program 26 (SFDP-26) instrument. The process of adapting the SFDP-26 to the veterinary clinical education setting and piloting the SFDP-Vet22 supported validity in the response process, but straightlining indicated that some students ([Formula: see text]) did not use the instrument as intended. Validity in internal structure was supported by the result of exploratory factor analysis with a six-factor solution. This was performed using principal axis factoring extraction and direct oblimin oblique rotation ([Formula: see text]) on Box–Cox-transformed data. Twenty of the 22 items loaded in the predicted factors. Cronbach's alphas for each factor were above .846, mean inter-item correlations ranged from .594 to .794, and mean item-total correlations ranged from .693 to .854. The six-factor solution explained 75.5% of the variation, indicating a robust model. The results indicated that the control of session, communication of goals, and self-directed learning factors were stable and consistently loaded as predicted and that learning climate, evaluation, and feedback were unstable. This suggests the transference of these constructs from medical to veterinary education and supports the intended use: low-stakes decisions about clinical educator performance and identifying areas of potential growth of educators.
Tuberculosis in Poland in 2022
Authors: Korzeniewska- Koseła Maria Joanna , Wesołowski Stefan 
Published: December 2024

BackgroundTuberculosis (TB) tuberculosis remains a worldwide health problem.ObjectiveTo evaluate the TB epidemiology in 2022 in Poland and compare it with European Union and European Economic Area (EU/EEA) countries.Material and methodsAnalysis of cases registered in 2022, drug susceptibility results, Central Statistical Office data on deaths due to tuberculosis, NIZP PZH – PIB data on tuberculosis as an AIDS-indicative disease, and the European Centre for Disease Prevention and Control report.ResultsIn 2022, 4314 cases of TB were registered in Poland (11.4 per 100 000), including 4148 cases of pulmonary tuberculosis. Pulmonary TB was confirmed bacteriologically in 81.9% (9.0 per 100 000). 98 patients had multidrug-resistant tuberculosis (MDR-TB). The highest incidence was in older age groups. The incidence in men was three times higher than in women. Foreigners (295) accounted for 6.8 per cent of all patients. Number of cases with HIV co-infection is unknown, just like the treatment outcomes. 472 persons died from TB (mortality 1.2 per 100 000).ConclusionsIn 2022, TB incidence in Poland was higher than in 2021 (by 17.5%). The percentage of TB cases with bacteriological confirmation was 80.9%, in EU/EEA countries 70.6%. The percentage of MDR-TB among cases with known drug susceptibility was lower than in EU/EEA countries (3.1% vs. 4.4%). In Poland the highest incidence was in older age groups, in EU/EEA countries in persons aged 25 to 44. Children represented 1% in total, in the EU/EEA countries 3.5%. In Poland, the incidence of tuberculosis in males was three times higher than in females, in EU/EEA countries twice. Foreigners made up 6.8% of all, in the EU/EEA countries 33.3%. In the EU/EEA countries the percentage of tuberculosis patients infected with HIV was 4.1% of cases with known HIV status, data not known for Poland. Treatment outcomes not reported in Poland. TB mortality in Poland has not decreased.
Perlindungan Hukum Terhadap Nasabah Bank Ditinjau dari Pasal 1 Angka 28 Undang-Undang Nomor 10 Tahun 1998 Tentang Perbankan
Authors: Handriani Aan , Suryani Reni , Suyadi Asip 
Published: December 2024

Perbankan merupakan pokok dari sistem keuangan setiap negara, karena perbankan merupakan salah satu motor penggerak pembangunan bangsa. Dalam rangka menghindari terjadinva penyalagunaan terhadap keuangan nasabah maka dibuat aturan khusus yang melarang bank untuk memberikan informasi tercatat kepada siapapun berkaitan dengan keuangan nasabah, kecuali dalam hal-hal tertentu yang disebutkan secara tegas dalam Undang-Undang. Berdasarkan hal tersebut maka permasalahan penelitian ini adalah bagaimana perlindungan hukum terhadap keamanan rahasia bank dalam menjaga kepentingan nasabah dan bagaimana akibat hukum terhadap para pihak bank yang melakukan pelanggaran dalam ketentuan Pasal 1 Angka 28 terkait rahasia bank. Metode yang dipakai dalam penulisan ini ialah dilakukan dengan menggunakan jenis penelitian hukum normative. Berdasarkan hasil penelitian diketahui bahwa ada beberapa mekanisme yang dipergunakan dalam rangka perlindungan nasabah bank ialah pembuatan peraturan baru, pelaksanaan peraturan yang ada, perlindungan nasabah deposan lewat lembaga asuransi deposito, memperketat perizinan bank, memperketat peraturan dibidang kegiatan bank, memperketat pengawasan bank. Dan akibat hukum terhadap pembukaan rahasia bank telah diatur secara tegas terutama dalam Undang-Undang Nomor 10 Tahun1998 tentang Perbankan, baik berupa ancaman pidana maupun denda secara administratif
ANALISIS PENDEKATAN MITIGASI BENCANA ALAM DI BADAN NASIONAL PENANGGULANGAN BENCANA KOTA BENGKULU
Authors: Susmita Anita Reni , Darmawi Edi , Suri Evsa Wulan 
Published: December 2024

Kota Bengkulu merupakan salah satu wilayah yang rawan bencana karena lokasi dan kondisi georafisnya termasuk dalam daerah yang rawan bencana, terutama bencana alam seperti banjir, tanah longsor, gempa dan bencana kebakaran. Kota ini terletak dipesisir barat pulau sumatra yang berhadapan langsung dengan samudra indonesia Berdasarkan uraian diatas peneliti tertarik untuk meneliti tentang Analisis Pendekatan Mitigasi bencana alam. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif.informan adalah sebagian subjek atau orang yang karakteristiknya telah diketahui yang memiliki kompetensi dan pengetahuan. Analisis data dalam penelitian ini ialah kualitatif data yang dikumpulkan dalam penelitian ini data yang berkaitan dengan pendekatan mitigasi bencana alam di Kota Bengkulu Mitigasi bencana harus dilakukan secara terencana dan komprehensif secara teknis mitigasi bencana dilakukan untuk mengurangi dampak suatu bencana.
Functional characterization of novel compound heterozygous missense SLC5A5 gene variants causing congenital dyshormonogenic hypothyroidism
Authors: Carro Gerardo Hernán , Martín Mariano , Savy Sofía , Peyret Victoria , Geysels Romina Celeste , Montes Francisco Andrés , Bernal Barquero Carlos Eduardo , Ricci Valentina , Masnata María Eugenia , Masini-Repiso Ana María , Papendieck Patricia , Tellechea Mariana Lorena , Chiesa Ana Elena , Nicola Juan Pablo 
Published: December 2024

IntroductionThe sodium/iodide symporter (NIS) mediates active iodide accumulation in the thyroid follicular cell. Biallelic loss-of-function variants in the NIS-coding SLC5A5 gene cause congenital dyshormonogenic hypothyroidism due to a defect in the accumulation of iodide, which is required for thyroid hormonogenesis.ObjectiveWe aimed to identify, and if so to functionally characterize, novel pathogenic SLC5A5 gene variants in a patient diagnosed with severe congenital dyshormonogenic hypothyroidism characterized by undetectable radioiodide accumulation in a eutopic thyroid gland, as well as in the salivary glands.MethodsThe coding region of the SLC5A5 gene was sequenced using whole-exome sequencing. In silico analysis and in vitro functional characterization of missense SLC5A5 gene variants were performed.ResultsProposita’s whole-exome sequencing revealed a novel pair of compound heterozygous missense variants in the SLC5A5 gene, c.1,627G&gt;A (p.G543R) and c.1,684T&gt;A (p.L562M). The parents were heterozygous carriers of the variants as determined by Sanger sequencing of the SLC5A5 gene. The p.G543R variant in the homozygous state has previously been associated with congenital hypothyroidism. The novel p.L562M variant was not reported in the Genome Aggregation Consortium dataset. In silico analysis of the pathogenic impact of the p.L562M variant yielded inconclusive results. Functional in vitro studies showed that the p.L562M variant reduces iodide accumulation due to defective expression of the mutant NIS protein at the plasma membrane. Notably, the aliphatic residue Leu at position 562 in the carboxy terminus of the protein, which is highly conserved in NIS orthologues, is required for NIS plasma membrane expression.ConclusionsWe report novel compound heterozygous missense SLC5A5 gene variants causing defective iodide accumulation, thus leading to congenital dyshormonogenic hypothyroidism.
External auditory canal cholesteatoma: staging and treatment strategies
Authors: He Guanwen , Lin Chang , Zhu Zhongshou , Liu Liangfeng , Wei Rifu , Hong Yiyun 
Published: December 2024

ObjectiveTo investigate clinical staging systems and appropriate treatment strategies for external auditory canal cholesteatoma (EACC).MethodsWe performed comparative analysis of the features of several staging schemes (Holt, Naim, Shin, Chang, Kaneda, Hn, and He) of EACC; retrospective analysis of the clinical data of 44 patients with primary EACC, and analyzed the prognosis.ResultsHe’s staging system (2019) was found to be particularly clear and practical. It defines each lesion stage comprehensively, reflecting the disease’s progressive nature. According to He’s staging, 2 stage I lesions underwent transcanal cholesteatoma removal (TCR). For 28 stage II lesions, TCR was performed, with 12 cases additionally undergoing canalplasty. Among the 10 stage IIIA lesions, 2 were managed through outpatient debridement, while the remaining 8 underwent TCR combined with partial mastoidectomy and canalplasty (including 2 cases with reconstruction). Three stage IIIC lesions underwent canalplasty and tympanoplasty following partial mastoidectomy. In one case of stage IV lesion, treatment involved mastoidectomy, canalplasty, and abscessectomy. Recurrence occurred in three patients with stage II lesions treated with TCR alone, while the remainder showed no recurrence. One stage IIIA lesion who underwent outpatient debridement only was unable achieve a completely dry ear, and another stage IIIC lesion whose perforated tympanic membrane did not heal due to a fungal infection.ConclusionClinicians can refer to He’s staging for the clinical staging of EACC to devise appropriate treatment strategies; minimally invasive surgical procedures can be flexibly chosen depending on the extent of lesion involvement, under the premise of complete resection of the lesion, but regular follow-up is crucial.
Interdisciplinaridade: uma proposta metodológica para o Curso Técnico em Informática Integrado ao Ensino Médio
Authors: Miranda Shymênia Regina Pereira , Silva Claudio Pereira da 
Published: December 2024

O presente trabalho tem como objetivo estruturar uma metodologia que oportunize o ensino de forma interdisciplinar no curso Técnico em Informática Integrado ao Ensino Médio. Fundamenta-se em teóricos como Fazenda (1994), Barros (2019), Japiassu (1976) e Morin (2004), entre outros. A investigação, que ocorreu por meio da pesquisa-ação, tencionou indicar caminhos que permitissem experiências didáticas interdisciplinares. Assim, o levantamento dos dados ocorreu mediante a análise documental do projeto pedagógico e a aplicação de questionário aos professores do referido curso. Os resultados da pesquisa apontam a interdisciplinaridade como uma abordagem pedagógica que visa a auxiliar no processo de compreensão e de apropriação do conhecimento de forma não fragmentada, constituindo um caminho profícuo para a complexa tarefa de trabalhar o ensino e a aprendizagem. Contudo, a apuração do questionário mostra que a ausência de conhecimento aprofundado sobre a temática por parte de alguns docentes pode gerar entraves para o desenvolvimento da referida abordagem. Em suma, esse trabalho apresenta uma proposta metodológica que orienta os profissionais do Ensino Médio Integrado em Informática a colocarem em prática o trabalho interdisciplinar. Acredita-se que a proposta da interdisciplinaridade pode ser uma oportunidade de romper a solidez dos domínios que separa as disciplinas e favorecer o diálogo entre os saberes.
Palavras-chave: Interdisciplinaridade. Metodologia pedagógica. Curso Técnico Integrado ao Ensino Médio.
Robotic systems for advanced additive manufacturing
Authors: Khattab Afraa , Felhő Csaba 
Published: December 2024

Additive manufacturing (AM) has revolutionized the way we layout and manufacture products. The inception of complicated geometries immediately from virtual models gives more freedom and flexibility. However, AM systems have boundaries in terms of building volume, space, and the capability to manufacture multi-material and multi-practical items. A mixture of robotics and AM has emerged as a promising solution. The robotic tool of AM expands its capabilities via the growing toolpath strategies and robotic trajectories, paving the way for the advent of large, more complicated, and functionally included factors. This review paper explores the current-day robotic structures of AM, outlining advantages and challenges, and highlighting studies’ achievements.