bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis
Authors: Chen GuanQiu , Yang Tao , Zhang Pu , Zhang Meng-Zhao , Yang Bo , Fan Jinhai 
Published: March 2020

Abstract
Background: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS) and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage.Methods: Systematic literature searches of MEDLINE, EMBASE and the Cochrane Library were performed. We pooled data on recurrence, progression, and CSS from 35 studies.Results: The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the difference in RFS between T1a sub-stage and T1b sub-stage (HR1.28, 95%CI 1.14-1.43). The significant difference was observed in PFS between the two arms (HR 2.18, 95%CI 1.95-2.44). Worse CSS was found in T1b patients than T1a patients (HR 1.45, 95%CI 1.28-1.64).Conclusions: T1 sub-staging system based on the invasion depth into muscularis mucosae (MM) can be a significant prognostic factor for RFS, PFS, and CSS of patients with T1-BC. Urologists and pathologists are encouraged to work together to give a precise sub-stage classification of T1-BC, and T1 sub-staging system should be a routine part of any histopathological report when possible. Different treatment strategies need to be developed for both T1a-BC and T1b-BC.
A multiobjective DEA model to assess the eco-efficiency of major cereal crops production within the carbon and nitrogen footprint in China
Authors: Chen Zhongdu , Xu Chunchun , Ji Long , fang fuping 
Published: March 2020

Abstract
[Background]Agricultural production systems are facing the challenges of increasing food production while reducing environmental cost, particularly in China. Understanding the eco-efficiency of the staple food crop production contributes to sustainable agriculture. In this study, the eco-efficiency of rice, wheat and maize production within the carbon (C) footprints (CF) and nitrogen (N) footprint (NF) at a province scale based on 555 farm survey data from China was measured in which a combination of life cycle assessment (LCA) and data envelopment analysis (DEA) was used. [Results] The results showed that the synthetic N fertilizer applications and CH4 emissions dominated the CF of crop production, while NH3 volatilization was the main contributors to the NF in the grain crop production process. Based on DEA-based sustainability performance assessment results, the eco-efficiency of major cereal crops production were all found to be inefficient (eco-efficiency <1). An increase in yields had only limited effects on improvement in eco-efficiency of rice, wheat and corn production because the yield increase potential rates were very small (0.1~3.4%), and there were no significant differences in increase potentials of yields between provinces. From a perspective of environmental impact reduction potential rates, GWP (22.7~25.1%) was more important for the environmental mitigation target than Nr (10.9~17.9%) in rice production, but the opposite scenario appears in wheat and corn production. [Conclusions] Improving crop management practices by reducing N fertilizer use and adopting water-saving irrigation technology could be strategic options to mitigate climate change and eutrophication and improve the eco-efficiency of the staple food crop production in Chinese agriculture.
Development and validation of 10-gene signature for predicting survival in patients with prostate cancer
Authors: Li Nan , Yu Kai , Zhong Ling , Zeng Dingyuan 
Published: March 2020

Abstract
Background. The prognosis for prostate cancer patients remains poor. High-throughput sequencing data provide a solid basis for identifying genes associated with cancer prognosis, but genetic markers are needed to predict the clinical outcome of prostate cancer. Methods. The Cancer Genome Atlas (TCGA) database (N = 551) was adopted to estimate the prognostic value of immune genes. RNA-seq and clinical follow-up data were downloaded from TCGA. The samples were randomly divided into training and test. Cox regression analyses and least absolute shrinkage and selection operator (LASSO) were conducted to develop an immune risk score. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and single sample Gene Set Enrichment Analysis (ssGSEA) were used for functional Analysis. Tumor Immune Estimation Resource (TIMER) is used to analyze the immune score, and RMS curve and clinical decision curve analysis is used to analyze the superiority of the comparison with published models. Results. Survival analyses revealed that 19 genes significantly associated with the overall survival (OS). 10-genes signature was ultimately obtained through random forest feature selection. Riskscore effectively stratified samples in the training, test, and external verification sets and all TCGA sets. The 5-year survival AUC in the training, verification sets and all TCGA sets were around 0.7. Univariate and multivariate analysis showed that 10-genes signature has good predictive performance in clinical. TIMER analysis shows that immunosuppression may reduce the chances of survival for patients with prostate cancer. Compared with published models, our model has a higher C-index. Conclusion. We constructed a 10-gene signature as a new prognostic marker for predicting survival of prostate cancer patients.
The Effect of Breastfeeding on Photorefractive Keratectomy Outcomes: A Retrospective Cohort Study
Authors: Zarei-Ghanavati Siamak , Eslami Amir Reza Daneshmand , Eslampoor Alireza , Rad Saeed Shokouhi , Akhlagi Saeed , Abrishami Mojtaba 
Published: March 2020

Abstract
Purpose To assess the refractive results, visual function, and safety of photorefractive keratectomy (PRK) in myopic breastfeeding women and compare them to healthy matched female controls. Methods Twelve mothers (23 eyes) who underwent PRK while they were still breastfeeding (B group) and continued it for at least three months participated in this retrospective matched cohort study. Twelve women (23 eyes) who were matched for age, refractive error, and operation data (NB group) were selected as the control group. Post-PRK results and complications were compared between the two groups. Results Twenty four breastfeeding mothers with a mean age of 29.70±1.8 (Standard Deviation) (range from 27 to 33years) were included. The average age in the study and the control group were 29.83 ± 1.80 and, 29.58 ± 1.98, prospectively, (P-value=0.749, T-test, poverty 0.1). The mean duration of breastfeeding was 47 weeks before surgery and 35 weeks after surgery. Conclusion Our study results did not indicate the adverse effects of breastfeeding on the results of PRK surgery. It seems that performing PRK is safe in the breastfeeding period.
Quality of Community-based Care Services in Korea
Authors: Yoon Kichan , Lee Insoo , Lee Youn-Tae , Lee Munjae 
Published: March 2020

Abstract
Background: Aging societies are increasing the need for care services. In order to solve the problem of care, we suggest community care, and through this, we will provide medical services that meet individual needs. Korea provides care services in advance of the community care project and implements quality control to improve the quality of these social services. Therefore, this study aims is to intend to compare and analyze the factors affecting user satisfaction in care services in both 2013 and 2016.Methods: We used quantified secondary data based on social services performed analysis reports. Based on the evaluation indexes for care service in 2013 and 2016, we used commonly used indexes for analysis.Results: As a result, there was a difference between care services quality evaluation (QE) indexes by profit type, and care services evaluation indexes had an effect on user satisfaction. In addition, the change rate in the care service evaluation scores affects the change rate in user satisfaction.Conclusions: Therefore, in order to increase satisfaction with care service, evaluation indexes by service type should be diversified and differentiated. In addition, it should be composed of field evaluations related to user satisfaction to provide care services appropriate for local characteristics.
Prevalence and Associated Factors of Suicidality in Japanese Adolescents: Results from a Population-based Questionnaire Survey
Authors: Nagamitsu Shinichiro , Mimaki Masakazu , Koyanagi Kenshi , Tokita Natsuko , Kobayashi Yoriko , Hattori Ritsuko , Ishii Ryuta , Matsuoka Michiko , Yamashita Yushiro , Yamagata Zentaro , Igarashi Takashi , Croarkin Paul E 
Published: March 2020

Abstract
Background Suicide is the first leading cause of death among Japanese adolescents. There are knowledge gaps regarding contemporary demographics and factors associated with suicidality in Japanese adolescents. This study examined the prevalence of suicidality and its associated factors among Japanese adolescents. Methods A population-based questionnaire survey was administered to 22,419 adolescents aged 13–18 years to investigate general health problems in adolescents. The questionnaire included 29 items regarding emotional status, family function, cyberbullying, suicidality, and stressors (focused on relationships with parents or friends, school performance, and sexual identity). We conducted multiple logistic regression analysis to identify the factors associated with suicidality in adolescents. We hypothesized that the prevalence of suicidality would be similar to that found internationally and bullying would be associated with suicide attempts. Results The prevalence of suicidal ideation and attempted suicide was 21.6/% and 3.5% in males and 28.5% and 6.6% in females, respectively. Bullying and family relationship stressors had the highest association with suicide attempts. Exposure to cyberbullying showed the highest odd ratios for both junior high and high school children (3.1, 95% confidence interval [CI] 2.1–4.4; 3.6, 95% Cl, 2.5–5.3, respectively). Adolescents accessed a variety of resources for stressors but chose the internet more frequently. Conclusions Our results indicate that suicidality is a common experience among Japanese adolescents. Although there are many associated risk factors, cyberbullying may be particularly concerning. Recognition of factors associated with adolescent suicidality will help inform future research and suicide prevention efforts for healthcare providers and families.
Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Incidence Meta-Analysis
Authors: Alsaied Amer , Islam Nazmul , Thalib Lukman 
Published: March 2020

Abstract
Background: Necrotizing Enterocolitis (NEC) is a major source of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence is not systematically evaluated. We conducted a systematic review and Meta-Analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Data were extracted from the selected papers and variables extracted included author and publication details, time period covered by the study, location and setting of the study and whether it was VLBW infants or preterm infants, incidence or number on NEC cases and size of population at risk were extracted from the selected papers. Additionally, risk of bias assessment of the included studies were carried out using a validated tool. Bias adjusted Quality Effect Model (QEM) were used to pool the estimates. Due to substantial heterogeneity, Random Effect Model (REM) estimates were also evaluated. The heterogeneity between studies were evaluated using the Cochrane Q statistics and Higgin’s I2 value. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias.Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The pooled estimate of the global incidence of NEC was 6.0% (95% CI: 4.0%-9.0%). There were substantial heterogeneity (I2 = 100%) between studies. Funnel plots showed no evidence of publication bias.Conclusion: The incidence of NEC vary considerably, although meta-regression failed provide evidence for any substantial regional variation. High quality studies along with detailed risk factors of NEC is warranted, to predict and NEC.
Adjuvant chemotherapy in average-risk adult medulloblastoma patients improves survival: a long term study
Authors: Franceschi Enrico , Minichillo Santino , Mura Antonella , Tosoni Alicia , Mascarin Maurizio , Tomasello Chiara , Bartolini Stefania , Brandes Alba Ariela 
Published: March 2020

Abstract
Background : The role of chemotherapy for average-risk adult patients remains controversial. Medulloblastoma is extremely rare in adults. Radical surgery and radiotherapy provide a significant control of disease and a good prognosis but about 25% of average-risk patients have a relapse and die because of disease progression. No data in average-risk adult patients on a direct comparison between radiotherapy alone and radiotherapy plus chemotherapy Methods : We analyzed 48 average-risk patients according to Chang classification diagnosed from 1988 to 2016. Results : Median age was 29 years (range 16-61). Main histology type were classic in 15 patients (31.3%) and desmoplastic in 15 patients (31.3%), 5 patients had extensive nodularity (10.4%) and 2 patients had large cells/anaplastic histology (4.2%). Twenty-four patients (50%) received adjuvant radiotherapy alone and 24 (50%) received radiotherapy and chemotherapy. After a median follow-up of 12.5 years, we found that chemotherapy increases PFS (PFS-15 82.3 ± 8.0% in RT-CT group vs. 38.5% ± 13.0% in RT group p=0.05) and OS (OS-15 89.3% 7.2% vs. 52.0% 13.1%, p=0.02). Among patients receiving chemotherapy, the reported grade ≥ 3 adverse events were: 9 cases of neutropenia; 6 cases of G3 neutropenia (25%) and 3 cases of G4 neutropenia (13%), 1 case of G3 thrombocytopenia (4%) and 2 cases of G3 nausea (8%). Conclusions : Our study with a long follow up period suggests that adding adjuvant chemotherapy to radiotherapy might improve PFS and OS in average-risk adult medulloblastoma patients
Prevalence of chronic renal insufficiency in the Chinese population: A cross-sectional study
Authors: Xu Lingling , Liu Jin , Li Dongling , Yang Hua , Shi Kechuan , He Aiqin , Wu Xiaomei , Wu Xian , Zhou Yang , Yang Junwei 
Published: March 2020

Abstract
Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide, and it has become a global health issue with a high economic burden. Chronic renal insufficiency (CRI), the most severe form of CKD, is associated with increased risks of cardiovascular disease, premature mortality, and decreased quality of life. However, epidemiological information on Chinese patients with CRI is still lacking. This study aimed to investigate the prevalence and epidemiological features of CRI in China. Methods: A total of 395,541 individuals aged ≥ 18 years residing in Binhai county, China were enrolled. e estimated the prevalence of CRI adjusting for age and sex. Associations of age, sex, blood pressure, body mass index, heart rate, and fasting blood glucose and triglyceride levels with CRI were examined. Odds ratios were calculated using a binary logistic regression model. Data were obtained from the records of universal health examinations of Binhai county residents conducted from January to December 2018. Results: The overall adjusted prevalence of CRI was 1.10% (95% confidence interval [CI], 1.07%-1.13%) in this Chinese adult population. The prevalence was 0.86% among men (95% CI, 0.82%-0.90%) and 1.34% among women (95% CI, 1.29%-1.39%). Female sex, age (per 10-year increase), central obesity, triglyceride levels (per 118-mg/dl increase), systolic blood pressure (per 10-mmHg increase), heart rate (per 10-beats/min increase) and fasting blood glucose ≥ 100 mg/dl were found to be independent risk factors for CRI. Conclusions: The overall prevalence of CRI in Chinese adults was 1.10%. Age, female sex, central obesity, higher triglycerides, SBP, heart rate and elevated fasting glucose levels were all independent risk factors associated with decreased eGFR. Health policies to prevent CRI are urgent among this population.
Soil texture, infective juvenile concentration, and soil organic matter influence the efficacy of Steinernema feltiae isolate Lican Ray
Authors: Lankin Gabriela , Vidal-Retes Giselle , Allende Geraldine , Castaneda-Alvarez Carlos , San-Blas Ernesto , Aballay Erwin 
Published: March 2020

Abstract
The influence of infective juveniles (IJs) concentration, soil texture, IJ-host distance and organic matter (OM) content, at different decomposition degree, on the activity of the nematode Steinernema feltiae isolate Lican Ray (LR) was examined using Galleria mellonella larvae. Bioassays were conducted in tubes of varied length, filled with soil of different textures, placed either vertically or horizontally. In the concentration assay, highest IJ concentrations caused maximum larval mortality in all soil types (440, 2,200 and 4,400 IJs in clay, loam and sandy loam). In the second assay, soil texture (loam, clay or sandy loam) interacted significantly with IJ-host distance (10, 20, 30, 40 cm, horizontally; 30, 50, 70 cm, vertically), and distances of 30 cm or more affected IJ effectiveness on the control of G. mellonella. The effect was stronger in clay and sandy loam than in loam soils, where IJ moved up to 40 cm horizontally and 70 cm vertically. In the third assay, OM content (0, 2, 4, 6 and 8%) and its decomposition degree (initial, medium and advanced) did not interact to influence IJ movement in all treatments that contained any percentage of OM (2–8%). Only in the soil with no OM, IJ did not cause death of larvae at all. These results show the potential of S. feltiae LR to be used in different soil textures, as long as the content of soil OM allows its dispersal and host infection, in order to optimize the pest-control activity of the nematode.
Cyberbullying: relationship with developmental variables and cyber victimization▪
Authors: Akgül Gülendam , Artar Müge 
Published: March 2020

Abstract

Background and objective:
Cyberbullying is increasingly turning into a significant problem for children and adolescents due to its adverse psychological and academic outcomes. In the present study, the protective and risk factors for cyberbullying has been investigated. One of the aims of the study was to examine the relationship between peer relations, negative emotion regulation strategies, and cyberbullying. The successful identity development process is thought to influence both cyberbullying behaviors as well as adolescents’ peer relations and emotion regulation. Also, cyber victimization is seen as a risk factor for cyberbullying. The second aim of the study is to investigate the causal relationship between cyber victimization and cyberbullying.

Method:
The study is a descriptive research in which both cross-sectional and longitudinal data were used. In the cross-sectional part of the study, 1,151 adolescents have participated, and the data of the second wave was obtained from 322 of them four months later. Data were analyzed through structural equation modeling (SEM) and hierarchical regression analyses.

Results and conclusion:
According to the results of SEM, good peer relations predicted less cyberbullying. The expressive repression explained the cyberbullying through peer relationships. For identity development, contrary to expectations, commitment dimension of identity seemed to be positively related to more cyberbullying and so did higher reconsideration of commitment. Cross-lagged panel analyses revealed that Time 1 cyber victimization predicted Time 2 cyberbullying. Given the pattern of cross-lagged relationships, it was tentatively inferred that cyber victimization was the temporal precursor to cyberbullying. The results of the study have implications for the prevention of cyberbullying.
Parametric prediction of finite population total under Informative sampling and nonignorable nonresponse
Authors: Eideh Abdulhakeem 
Published: March 2020

Abstract
In this paper, we combine two methodologies used in the model-based survey sampling, namely the prediction of the finite population total, named T, under informative sampling and full response, see Sverchkov and Pfeffermann (2004), and the prediction of T with a noninformative sampling design and the nonignorable nonresponse mechanism, see Eideh (2012). The former approach involves the dependence of the first order inclusion probabilities on the study variable, while the latter involves the dependence of the probability of nonresponse on unobserved or missing observations. The main aim of the paper is to consider how to account for the joint effects of informative sampling designs and not-missing-at-random response mechanism in statistical models for complex survey data. For this purpose, theoretically, we use the response distribution and relationships between the moments of the superpopoulation, the sample, sample-complement, response, and nonresponse distributions for the prediction of finite population totals, see Eideh (2016). The derived parametric predictors of T use the observation for the response set of the study variable or variable of interest, values of auxiliary variables and their population totals, sampling weights, and propensity scores. An interesting outcome of the T study is that most predictors known from model-based survey sampling can be derived as a special case from this general theory, see Chambers and Clark (2012).
Horvitz-Thompson estimator based on theauxiliary variable
Authors: Al-Jararha J. , Sulaiman Mazen 
Published: March 2020

Abstract
In this paper, the Horvitz and Thompson (1952) estimator will be modified; so that, the modified estimators will use the availability of the auxiliary variable. Furthermore, the modified estimators are extended to be used in stratified sampling designs. Empirical studies are given for comparison purposes.
Using the ICAPM to estimate the cost of capital of stock portfolios: empirical evidence on the Warsaw Stock Exchange
Authors: Urbański Stanisław , Leśkow Jacek 
Published: March 2020

Abstract
The aim of this paper is to present the method for estimating the cost of capital of typical portfolios available on the Warsaw Stock Exchange. The authors introduce the three factor Fama-French model and its two modifications. They also apply the bootstrap method to evaluate the variability of their estimation method. The cost of capital they refer to is related to portfolios of real options linked to projects. The market returns are generated both by stock companies running such projects and by real options modifying selected projects. The estimated cost of capital can serve as a valuable indicator for investors and for managers overseeing portfolios of stocks. Also, such an indicator can serve as a general reference while making business decisions related to new. The study demonstrated that the estimated cost of capital assumes highest values for value portfolios and stock companies with high financial indicators and, at the same time, low market prices compared to their book value. By the same token, the estimated cost of capital assumes low values for growth portfolios and for stock companies characterised by low financial indicators and, at the same time, high market prices compared to their book values.