bluuebunny/crossref_metadata_2025_split huggingface dataset:
Récords olímpicos: humanos vs insectos
Authors: Zenner de Polanía Ingeborg 
Published: December 2020

Basado en observaciones, en mediciones y en literatura acerca de las habilidades deportivas de los insectos, en los tres deportes reconocidos de los Juegos Olímpicos de Verano, el atletismo, la gimnasia y la natación, se comparan algunas marcas deportivas, recientemente establecidas por hombres y por mujeres con aquellos que, determinados insectos, sostienen desde hace millones de años. Estos artrópodos, si compitiesen con los humanos, ganarían en la mayoría de las justas, en las que, por sus características, podrían participar, ya sea a nivel mundial o en juegos olímpicos. En el levantamiento de pesas, en cualquiera de las modalidades, compiten los escarabajos peloteros y las hormigas con los insectos; ganarían los cucarrones, reconocidos también como los insectos sagrados de los antiguos egipcios. Disputa con ellos la medalla, el escarabajo hércules o rinoceronte, Dynastes hercules, cucarrón emblemático de las selvas tropicales de Suramérica, incluyendo a Colombia. Las chinches acuáticas de las familias Notonectidae y Corixidae son nadadores por excelencia de dos estilos, espalda y pecho y no es la pulga, que se pensaba sostenía el récord mundial de salto alto y largo, sino un insecto salivazo o mión (Cercopidae), plaga de alfalfa. Igualmente, y como ocurre casi siempre en los juegos olímpicos, donde alguien le quita el récord a un atleta, hace poco, otro insecto le quitó la marca de corredor más rápido a la cucaracha americana. Afortunadamente, los humanos no compiten en deportes con los insectos, pero sí luchan con algunos de ellos, con éxito limitado, principalmente, por alimentos.
Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium
Authors: Burggraaf Maroeska J. , Waanders Lisette , Verlaan Mariska , Maaskant Janneke , Houben Diane , Luirink Joen , Bitter Wilbert , Kuijl Coen , Molthoff Carla F.M. 
Published: December 2020

BACKGROUND: Bladder cancer is the ninth most common cancer in men. 70% of these tumors are classified as non-muscle invasive bladder cancer and those patients receive 6 intravesical instillations with Mycobacterium bovis BCG after transurethral resection. However, 30% of patients show recurrences after treatment and experience severe side effects that often lead to therapy discontinuation. Recently, another vaccine strain, Salmonella enterica typhi Ty21a, demonstrated promising antitumor activity in vivo. Here we focus on increasing bacterial retention in the bladder in order to reduce the number of instillations required and improve antitumor activity. OBJECTIVE: To increase the binding of Ty21a to the bladder wall by surface labeling of the bacteria with adhesion protein FimH and to study its effect in a bladder cancer mouse model. METHODS: Binding of Ty21a with surface-labeled FimH to the bladder wall was analyzed in vitro and in vivo. The antitumor effect of a single instillation of Ty21a+FimH in treatment was determined in a survival experiment. RESULTS: FimH-labeled Ty21a showed significant ( p < 0.0001) improved binding to mouse and human cell lines in vitro. Furthermore, FimH labeled bacteria showed ∼5x more binding to the bladder than controls in vivo. Enhanced binding to the bladder via FimH labeling induced a modest improvement in median but not in overall mice survival. CONCLUSIONS: FimH labeling of Ty21a significantly improved binding to bladder tumor cells in vitro and the bladder wall in vivo. The improved binding leads to a modest increase in median survival in a single bladder cancer mouse study.
On the relation between keys and link keys for data interlinking
Authors: Atencia Manuel , David Jérôme , Euzenat Jérôme 
Published: December 2020

Both keys and their generalisation, link keys, may be used to perform data interlinking, i.e. finding identical resources in different RDF datasets. However, the precise relationship between keys and link keys has not been fully determined yet. A common formal framework encompassing both keys and link keys is necessary to ensure the correctness of data interlinking tools based on them, and to determine their scope and possible overlapping. In this paper, we provide a semantics for keys and link keys within description logics. We determine under which conditions they are legitimate to generate links. We provide conditions under which link keys are logically equivalent to keys. In particular, we show that data interlinking with keys and ontology alignments can be reduced to data interlinking with link keys, but not the other way around.
The prevalence of metabolic syndrome in drivers: A meta-analysis and systematic review
Authors: Soltaninejad Mohammadreza , Yarmohammadi Hamed , Madrese Elham , Khaleghi Saeed , Poursadeqiyan Mohsen , Aminizadeh Mohsen , Saberinia Amin 
Published: December 2020

BACKGROUND: Metabolic syndrome is an increasing disorder, especially in night workers. Drivers are considered to work during 24 hours a day. Because of job characteristics such as stress, low mobility and long working hours, they are at risk of a metabolic syndrome disorder. OBJECTIVES: The purpose of this study is a meta-analysis and systematic review of the prevalence of metabolic syndrome in drivers. METHODS: In this systematic review, articles were extracted from national and international databases: Scientific Information Database (SID), Iran Medex, Mag Iran, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus. Data analysis was performed using meta-analysis and systematic review (random effect model). The calculation of heterogeneity was carried out using the I2 index and Cochran’s Q test. All statistical analyses were performed using STATA software version 11. RESULTS: A total of nine articles related to the prevalence of metabolic syndrome in drivers in different regions of the world from 2008 to 2016 were obtained. The total sample size studied was 26156 with an average of 2906 samples per study. The prevalence of metabolic syndrome in drivers was 34% (95% CI: 30–37) CONCLUSIONS: According to the results of this study, the prevalence of metabolic syndrome in drivers is high. Occupational stress, unhealthy diet and physical inactivity cannot be cited as causes of metabolic syndrome prevalence in drivers. Therefore, to maintain and to improve the health of this group, the implementation of preventive, therapeutic and rehabilitation measures for these people as well as training should be considered.
Hybrid diffusion tensor imaging feature-based AD classification
Authors: Deng Lan , Wang Yuanjun 
Published: December 2020

BACKGROUND: Effective detection of Alzheimer’s disease (AD) is still difficult in clinical practice. Therefore, establishment of AD detection model by means of machine learning is of great significance to assist AD diagnosis. OBJECTIVE: To investigate and test a new detection model aiming to help doctors diagnose AD more accurately. METHODS: Diffusion tensor images and the corresponding T1w images acquired from subjects (AD = 98, normal control (NC) = 100) are used to construct brain networks. Then, 9 types features (198×90×9 in total) are extracted from the 3D brain networks by a graph theory method. Features with low correction in both groups are selected through the Pearson correlation analysis. Finally, the selected features (198×33, 198×26, 198×30, 198×42, 198×36, 198×23, 198×29, 198×14, 198×25) are separately used into train 3 machine learning classifier based detection models in which 60% of study subjects are used for training, 20% for validation and 20% for testing. RESULTS: The best detection accuracy levels of 3 models are 90%, 98% and 90% with the corresponding sensitivity of 92%, 96%, and 72% and specificity of 88%, 100% and 94% when using a random forest classifier trained with the Shortest Path Length (SPL) features (198×14), a support vector machine trained with the Degree Centrality features (198×33), and a convolution neural network trained with SPL features, respectively. CONCLUSIONS: This study demonstrates that the new method and models not only improve the accuracy of detecting AD, but also avoid bias caused by the method of direct dimensionality reduction from high dimensional data.
Defining and recognising clinical deterioration in the prehospital setting (PRECLuDE study): a systematic scoping review
Authors: Bourke-Matas Emma , Bosley Emma , Gowens Paul , Smith Karen , Bowles Kelly-Ann 
Published: December 2020

<p><strong>Introduction</strong></p><p>Early identification of high-risk patients in the prehospital environment is crucial as it enables early intervention, transportation, and may determine the trajectory of future care. Although early warning systems (EWS) in-hospital are well established, it remains unclear whether adaptations of these systems can simply be extrapolated to prehospital care. This scoping review aims to explore how the current literature defines and recognises clinical deterioration in the prehospital setting.</p><p> </p><p><strong>Methods</strong></p><p>In December 2019, a systematic search of five databases using a combination of terms describing ‘paramedic’, were integrated with terminology relating to ‘recognition’ of ‘clinical deterioration’. Additional reference chaining was also undertaken.</p><p> </p><p><strong>Results</strong></p><p>A total of eight papers met the inclusion criteria. Seven out of eight studies included a definition, however these were primarily ad-hoc and fundamentally formed to support the creation of varying EWS. The prevalence of prehospital clinical deterioration is poorly explored in the literature, with only two studies discussing the frequency deterioration (5.1%). Furthermore, studies reported that paramedics were inadequate at identifying clinical deterioration due to medical aetiology by comparison to trauma. Additionally, a number of articles reported an association between clinician experience and recognition of clinical deterioration. As the topic of prehospital clinical deterioration has rapidly moved to focus on the potential implementation of EWS, with few studies providing fundamental description of the concept and its characteristics, there is no standardised operational definition available in the literature. The development of this definition is crucial to assessing clinical deterioration and improving the efficacy of EWS. Not only could this lead to improving early identification of risk factors, but it can lay the foundations for the development of an effective EWS.</p><p> </p><p><strong>Conclusion</strong></p><p>This review has found that further quality research in this understated space is warranted to increase understanding and early identification of the deteriorating patient, prevent unnecessary harm, and ultimately, improve patient outcomes. </p>
Youth Action Against Moral Deterioration
Authors: Mitu Mehedi Mala 
Published: December 2020

In Past, Chinese traveler Fa-hien (14th century) to Ibn batuta (14th century) or from Nicola Kanti (15th century) to Queen Elizabeth (20th Century), every travelers and scholars are attracted by the charms and fame of Bangladesh. Ibn batuta described Bengal as “a hell full of bounties” and “wealthiest” land of the world”. But now a day, along this progress anxiety has proportionately increased. In this present age, science and technology are the easily available to common people. The world has come to a handful but yet people are still not so happy. As if the demand is insatiable. So, anxiety, apathy, intolerance, fear and panic are increased. Morality is deemed declining. Why immorality among young increased is a concern? Mark Twain said, “Always do what is right, it will gratify half of mankind”. What is right? a vantage point is needed to know. Our moral values which guide us and aids us in our conscious mobility in life. This article tries to find out the cause root of immorality among young generation and how to protect young generation from this moral deterioration.
Leafy vegetables in Chapai Nawabganj district of Bangladesh focusing on medicinal value
Authors: Rahman AHM Mahbubur , Khatun Most Mejanara 
Published: December 2020

Leafy vegetables in Chapai Nawabganj district of Bangladesh was studied from January to December 2019. A total of 111 species belonging to 59 genera under 30 families were recorded, out of which, 52.25% species were wild and 46.84% species were cultivated in this study. Status of occurrence has been recorded for proper conservation management and sustainable utilization of the taxa resulting in 81.98% to be common, 17.11% as rare and 0.90% are found as vulnerable in the study area. A total of 93 medicinal plants have been documented with their uses for the cure of more than 53 diseases. The study showed that the people of Chapai Nawabganj district use leafy vegetables to treat their diseases. Therefore, the documented leafy vegetables should be further investigated for their efficacy and safety to be integrated into conventional medicine. Further more these leafy vegetables need to be conserved for their sustainable utilization.
Bangladesh J. Plant Taxon. 27(2): 359-375, 2020 (December)
Elucidating differences between two confusing Shorea contorta S. Vid and Pentacme mindanensis Foxw. species of Dipterocarpaceae via leaf morphometrics: An initial investigation
Authors: Mazo Kean Roe F , Aribal Lowell G 
Published: December 2020

Abstract not available
Bangladesh J. Plant Taxon. 27(2): 461-465, 2020 (December)
Prediction of Sediment Yield in the Middle Reaches of the Yellow River Basin Under Extreme Precipitation
Authors: Dang Suzhen , Liu Xiaoyan , Yin Huijuan , Guo Xinwei 
Published: December 2020

The Yellow River is one of the rivers with the largest amount of sediment in the world. The amount of incoming sediment has an important impact on water resources management, sediment regulation schemes, and the construction of water conservancy projects. The Loess Plateau is the main source of sediment in the Yellow River Basin. Floods caused by extreme precipitation are the primary driving forces of soil erosion in the Loess Plateau. In this study, we constructed the extreme precipitation scenarios based on historical extreme precipitation records in the main sediment-yielding area in the middle reaches of the Yellow River. The amount of sediment yield under current land surface conditions was estimated according to the relationship between extreme precipitation and sediment yield observations in the historical period. The results showed that the extreme rainfall scenario of the study area reaches to 159.9 mm, corresponding to a recurrence period of 460 years. The corresponding annual sediment yield under the current land surface condition was range from 0.821 billion tons to 1.899 billion tons, and the median annual sediment yield is 1.355 billion tons, of which more than 91.9% of sediment yields come from the Hekouzhen to Longmen sectionand the Jinghe River basin. Therefore, even though the vegetation of the Loess Plateau has been greatly improved, and a large number of terraces and check dams have been built, the flood control and key project operation of the Yellow River still need to be prepared to deal with the large amount of sediment transport.
Th17/Treg-Related Transcriptional Factor Expression and Cytokine Profile in Patients With Rheumatoid Arthritis
Authors: Paradowska-Gorycka Agnieszka , Wajda Anna , Romanowska-Próchnicka Katarzyna , Walczuk Ewa , Kuca-Warnawin Ewa , Kmiolek Tomasz , Stypinska Barbara , Rzeszotarska Ewa , Majewski Dominik , Jagodzinski Pawel Piotr , Pawlik Andrzej 
Published: December 2020

ObjectivesThe aim of our study was to determine whether there is a correlation between transcription factors expression and Th17/Treg ratio, cytokine profile in the RA phenotype as well as to identify transcription factors that could be a potential biomarker for RA.MethodsThe study was conducted on 45 patients with RA, 27 patients with OA and 46 healthy controls (HCs). Th17 and Treg frequency was determined by flow cytometry (15 patients with RA/OA and 15 subjects of HC). Gene expression was estimated by qPCR, and the serum cytokine levels were determined by ELISA.ResultsThe percentage of Treg (CD4+CD25highCD127-) cells in RA patients was lower than in OA patients or HCs. Proportions of Th17 (CD4+CCR6+CXCR3-) cells were higher in RA and OA in comparison to HCs. STAT5 showed a very high expression in the blood of RA patients compared to healthy subjects. The expression of STAT5 and HELIOS was not detected in Th17 cells. A positive correlation between SMAD3 and STAT3 in RA patients was observed. Negative correlations between HIF-1A and SMAD2 in RA Treg cells and DAS-28 score were observed. The range of serum of IL-17 and IL-21 were higher in RA patients than in OA patients. Concentrations of serum IL-2 and IFN-γ were higher in RA and OA patients than in healthy subjects. Based on the ROC analysis, the diagnostic potential of the combination of HIF1A, SMAD3 and STAT3, was determined at AUC 0.95 for distinguishing RA patients from HCs. For distinguishing RA patients from OA patients the diagnostic potential of the combination of SMAD2, SMAD3, SMAD4 and STAT3, was determined at AUC 0.95.ConclusionBased on our study, we conclude that SMAD3 and STAT3 could be potential diagnostic biomarkers for RA.
NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart
Authors: Zhang Hong , Xiao Yang , Nederlof Rianne , Bakker Diane , Zhang Pengbo , Girardin Stephen E. , Hollmann Markus W. , Weber Nina C. , Houten Sander M. , van Weeghel Michel , Kibbey Richard G. , Zuurbier Coert J. 
Published: December 2020

BackgroundNOD-like receptors (NLR) are intracellular sensors of the innate immune system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia-reperfusion injury (IRI) and metabolism. No information is available on a possible role of anti-inflammatory NLRs on IRI and metabolism in the intact heart. Here we hypothesize that the constitutively expressed, anti-inflammatory mitochondrial NLRX1, affects IRI and metabolism of the isolated mouse heart.MethodsIsolated C57Bl/6J and NLRX1 knock-out (KO) mouse hearts were perfused with a physiological mixture of the essential substrates (lactate, glucose, pyruvate, fatty acid, glutamine) and insulin. For the IRI studies, hearts were subjected to either mild (20 min) or severe (35 min) ischemia and IRI was determined at 60 min reperfusion. Inflammatory mediators (IL-6, TNFα) and survival pathways (mito-HKII, p-Akt, p-AMPK, p-STAT3) were analyzed at 5 min of reperfusion. For the metabolism studies, hearts were perfused for 35 min with either 5.5 mM 13C-glucose or 0.4 mM 13C-palmitate under normoxic conditions, followed by LC-MS analysis and integrated, stepwise, mass-isotopomeric flux analysis (MIMOSA).ResultsNLRX1 KO significantly increased IRI (infarct size from 63% to 73%, end-diastolic pressure from 59 mmHg to 75 mmHg, and rate-pressure-product recovery from 15% to 6%), following severe, but not mild, ischemia. The increased IRI in NLRX1 KO hearts was associated with depressed Akt signaling at early reperfusion; other survival pathways or inflammatory parameters were not affected. Metabolically, NLRX1 KO hearts displayed increased lactate production and glucose oxidation relative to fatty acid oxidation, associated with increased pyruvate dehydrogenase flux and 10% higher cardiac oxygen consumption.ConclusionDeletion of the mitochondrially-located NOD-like sensor NLRX1 exacerbates severe cardiac IR injury, possibly through impaired Akt signaling, and increases cardiac glucose metabolism.
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Authors: Stanifer Megan L. , Guo Cuncai , Doldan Patricio , Boulant Steeve 
Published: December 2020

Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The two most important IFNs that can be produced by virtually all cells in the body during intrinsic innate immune response belong to two distinct families: the type I and type III IFNs. The type I IFN receptor is ubiquitously expressed whereas the type III IFN receptor’s expression is limited to epithelial cells and a subset of immune cells. While originally considered to be redundant, type III IFNs have now been shown to play a unique role in protecting mucosal surfaces against pathogen challenges. The mucosal specific functions of type III IFN do not solely rely on the restricted epithelial expression of its receptor but also on the distinct means by which type III IFN mediates its anti-pathogen functions compared to the type I IFN. In this review we first provide a general overview on IFNs and present the similarities and differences in the signal transduction pathways leading to the expression of either type I or type III IFNs. By highlighting the current state-of-knowledge of the two archetypical mucosal surfaces (e.g.the respiratory and intestinal epitheliums), we present the differences in the signaling cascades used by type I and type III IFNs to uniquely induce the expression of ISGs. We then discuss in detail the role of each IFN in controlling pathogen infections in intestinal and respiratory epithelial cells. Finally, we provide our perspective on novel concepts in the field of IFN (stochasticity, response heterogeneity, cellular polarization/differentiation and tissue microenvironment) that we believe have implications in driving the differences between type I and III IFNs and could explain the preferences for type III IFNs at mucosal surfaces.
How to Estimate the Binder: Aggregate Ratio From Lime-Based Historic Mortars for Restoration?
Authors: Loureiro Alexandre Máximo Silva , Paz Simone Patrícia Aranha da , Angélica Rômulo Simões 
Published: December 2020

One of the most important studies from historic mortars is the binder:aggregate ratio, which is usually obtained through wet chemical analysis. Instrumental techniques and benchtop equipment have become increasingly important tools in the characterization of historic materials. The analysis of such materials has become more practical, faster and more accurate, and the sample preparation methods require less and less material. Thus, this article aims to investigate the validity of the results obtained by some of the methods and techniques used in historic materials analysis and determine the possibility of estimating the binder:aggregate ratio with adequate accuracy and precision. For this purpose, historic mortars from Belém do Pará, in northern Brazil, were selected, and the following quantification techniques were employed: wet chemical analysis, XRD, DSC and XRF. The results showed that the amounts of the components in the mortars could be quantified with the use of approximately 3 g of sample, thus providing one of the main pieces of information needed for the production of a restoration mortar: the binder:aggregate ratio.