bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of text messaging interventions for the management of depression: A systematic review and meta-analysis
Authors: Senanayake Buddhika , Wickramasinghe Sumudu I , Chatfield Mark D , Hansen Julie , Edirippulige Sisira , Smith Anthony C 
Published: October 2019

Introduction Depression is a leading cause of human disability. Telemedicine-based interventions using text messaging are currently being trialled for the management of community-based clients with clinical depression. However, little is known about the effectiveness of such methods. Methods We searched the databases PubMed, Embase, Informit, Cochrane Central Register of Controlled Trials, PsycINFO and Scopus for randomised controlled trials (RCTs) published between January 2000 and April 2019. Studies comparing text messaging interventions to a comparator group for patients with depression were included in the review. Articles were assessed for quality using the Joanna Briggs Institute critical appraisal checklist for RCTs. Results Nine RCTs (945 patients: 764 adults and 181 adolescents) were included in the systematic review. Five studies used text messaging as the only intervention, whilst the remaining combined text messaging with other treatment modalities such as behavioural activation or cognitive behavioural therapy. A meta-analysis was conducted on seven selected RCTs (845 patients: 664 adults and 181 adolescents). The standardised mean reduction in depression due to text messaging interventions was 0.23 (95% confidence interval: –0.02 to 0.48). There was evidence of heterogeneity in treatment effect between studies. Discussion There is marginal evidence supporting text messaging interventions as an effective treatment modality for people living with clinical depression. However, further research is needed to determine how best to utilise text-message interventions alongside other conventional forms of health services delivery.
Social Marketing’s Strengths, Weaknesses, Opportunities, and Threats (SWOT): A Commentary
Authors: Deshpande Sameer 
Published: October 2019

Background: Over the past half century, social marketing has come into its own, both as a discipline and a practice, for creating positive social outcomes. However, as the operating environment continues to evolve, the role of social marketing in the change landscape requires consideration. Focus of the article: In this article, the author presents a commentary on the present and future role of social marketing research and practice through the lens of a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis. Topics discussed in the analysis include the boundary definition of social marketing, modalities of practice, sources of funding, the complexity of target issues, and professional standing and competition. Importance to the social marketing field: Critical analysis of social marketing research and practice can assist to maintain and grow its relevance and adoption among key stakeholders. Recommendations for Research or Practice: Several recommendations are made for addressing the issues identified in the SWOT analysis. These include conscious effort to market social marketing; clarify the concept of audience orientation when designing social marketing solutions; address specific research questions that produce academic and managerial insights; utilize corporate partnerships creatively; offer social marketing course to retain accreditation of professions such as marketing, public health, environmental studies, or public administration; and, encourage documentation of initiatives. Limitations: The discussion presented here is based purely on opinions and experience of the author.
Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma
Authors: Stelling Anna , Wu Cheuk-Ting , Bertram Katrin , Hashwah Hind , Theocharides Alexandre P. A. , Manz Markus G. , Tzankov Alexandar , Müller Anne 
Published: October 2019

Key Points
SMAD1 is silenced by hypermethylation in DLBCL cell lines and patient samples but not in peripheral blood B cells or lymph nodes. DAC treatment restores SMAD1 expression and reverses DLBCL growth in several xenotransplantation and patient-derived xenograft models.
Gaps in care of patients living with pulmonary fibrosis: a joint patient and expert statement on the results of a Europe-wide survey
Authors: Moor Catharina C. , Wijsenbeek Marlies S. , Balestro Elisabetta , Biondini Davide , Bondue Benjamin , Cottin Vincent , Flewett Ron , Galvin Liam , Jones Steve , Molina-Molina Maria , Planas-Cerezales Lurdes , Prasse Antje , Prosch Helmut , Russell Anne-Marie , Viegas Michel , Wanke Guenther , Wuyts Wim , Kreuter Michael , Bonella Francesco 
Published: October 2019

IntroductionPulmonary fibrosis (PF) and its most common form, idiopathic pulmonary fibrosis (IPF), are chronic, progressive diseases resulting in increasing loss of lung function and impaired quality of life and survival. The aim of this joint expert and patient statement was to highlight the most pressing common unmet needs of patients with PF/IPF, putting forward recommendations to improve the quality of life and health outcomes throughout the patient journey.MethodsTwo online surveys for patients and healthcare professionals (HCPs) were conducted by the European Idiopathic Pulmonary Fibrosis and Related Disorders Federation (EU-IPFF) in 14 European countries.ResultsThe surveys were answered by 286 patients and 69 HCPs, including physicians and nurses. Delays in diagnosis and timely access to interstitial lung disease specialists and pharmacological treatment have been identified as important gaps in care. Additionally, patients and HCPs reported that a greater focus on symptom-centred management, adequate information, trial information and increasing awareness of PF/IPF is required.ConclusionsThe surveys offer important insights into the current unmet needs of PF/IPF patients. Interventions at different points of the care pathway are needed to improve patient experience.
Incidence, comorbidity and survival rate of hypersensitivity pneumonitis: a national population-based study
Authors: Rittig Anne Hald , Hilberg Ole , Ibsen Rikke , Løkke Anders 
Published: October 2019

Background and objectivesHypersensitivity pneumonitis (HP) is a rare disease, which can lead to premature death. Few studies have investigated HP on a national level. The objective of this study was to investigate incidence, survival rate, and comorbidity of HP in Denmark.MethodsUsing the Danish National Patient Registry we identified all patients with a first-time diagnosis of HP between 1998 and 2010. Patients with HP were matched 1:4 with controls by sex, age and geography in this case-control study. Comorbidity 3 years prior to diagnosis was explored by the Charlson score index. Survival rates were assessed using Kaplan–Meier curves and hazard ratios.ResultsWe identified 753 patients during the observation period equalling an average HP incidence of 1.16 per 100 000 citizens. Patients with HP had a significantly higher Charlson score index when compared with the matched controls and an increased risk of dying (hazard ratio 1.98, CI 1.61–2.58,se0.14, p<0.001). Survival rates of HP were lower at all time points when compared with the matched control population. The decline in survival was observed for both male and female patients with HP with no clear sex difference. Most deaths were related to diseases of the heart and lungs.ConclusionsIn this Danish longitudinal nationwide observational study we found an increased Charlson score index combined with a higher mortality without sex difference among patients with HP compared with a healthy control group, mainly due to diseases of the heart and lungs.
Atypical presentation of Lemierre’s syndrome: case report and literature review
Authors: Laurencet Marie-Eva , Rosset--Zufferey Sarah , Schrenzel Jacques 
Published: October 2019

Abstract

Background
The classic Lemierre’s syndrome refers to a septic thrombosis of the internal jugular vein, usually caused by a Fusobacterium necrophorum infection starting in the oral cavity, and typically complicated by pulmonary emboli. However, unusual forms of the disorder have been rarely reported.

Case presentation
We describe an unusual case of a previously healthy 58-year-old male with Lemierre’s syndrome, manifesting with lumbar pain and fever. A thrombosis of the iliac veins and abscesses in the right iliac and the left psoas muscles was diagnosed by a computed tomography scan, together with a right lung pneumonia complicated by pleural effusion and an L4-L5 spondylodiscitis. Blood culture and pus drainage were positive for Fusobacterium nucleatum and an atypical Lemierre’s syndrome was suspected. The patient was treated with anticoagulant therapy for 12 weeks and intravenous antibiotic therapy for 6 weeks with a good evolution and resolution of the thrombosis.

Conclusions
This case illustrates the thrombogenic and thromboembolic tendency of Fusobacterium nucleatum and its potential invasiveness, regardless of the site of primary infection. The concept of an atypical Lemierre’s syndrome is redefined here to take into consideration non-cervical sites.
Correlation between immune-related adverse events and prognosis in patients with gastric cancer treated with nivolumab
Authors: Masuda Ken , Shoji Hirokazu , Nagashima Kengo , Yamamoto Shun , Ishikawa Masashi , Imazeki Hiroshi , Aoki Masahiko , Miyamoto Takahiro , Hirano Hidekazu , Honma Yoshitaka , Iwasa Satoru , Okita Natsuko , Takashima Atsuo , Kato Ken , Boku Narikazu 
Published: October 2019

AbstractBackgroundRecent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors were associated with clinical benefit in patients with melanoma or lung cancer. In advanced gastric cancer (AGC) patients, there have been few reports about the correlation between irAEs and efficacy of immune checkpoint inhibitors. In this study, we retrospectively investigated the correlation between irAEs and efficacy in AGC patients treated with nivolumab.MethodsThe subjects of this study were AGC patients received nivolumab monotherapy between January 2015 and August 2018. IrAEs were defined as those AEs having a potential immunological basis that required close follow-up, or immunosuppressive therapy and/or endocrine therapy. We divided the patients who received nivolumab into two groups based on occurrence of irAEs; those with irAEs (irAE group) or those without (non-irAE group). We assessed the efficacy in both groups.ResultsOf the 65 AGC patients that received nivolumab monotherapy, 14 developed irAEs. The median time to onset of irAEs was 30.5 days (range 3–407 days). Median follow-up period for survivors was 32 months (95% CI, 10.8 to 34.5). The median progression-free survival was 7.5 months (95% CI, 3.6 to 11.5) in the irAE group and 1.4 months (95% CI, 1.2 to 1.6) in the non-irAE group (HR = 0.11,p < 0.001). The median overall survival was 16.8 months (95% CI, 4.4 to not reached) in the irAE group and 3.2 months (95% CI, 2.2 to 4.1) in the non-irAE group (HR = 0.17,p < 0.001). Multivariate analysis demonstrated that number of metastatic sites ≥2 (HR = 2.15; 95% CI, 1.02 to 4.54), high ALP level (HR = 2.50; 95% CI, 1.27 to 4.54), and absence of irAEs (HR = 9.54, 95% CI, 3.34 to 27.30 for yes vs. no) were associated with a poor prognosis. The most frequent irAEs was diarrhea/colitis (n = 5). Grade 3 adverse events were observed in 6 patients; hyperglycemia (n = 2), diarrhea/colitis (n = 1), adrenal insufficiency (n = 1), aspartate aminotransferase increased (n = 1), peripheral motor neuropathy (n = 1). There were no grade 4 or 5 adverse events related to nivolumab.ConclusionsDevelopment of irAEs was associated with clinical benefit for AGC patients receiving nivolumab monotherapy.
Health-related quality of life in adults undergoing transthoracic device closure of ventricular septal defect
Authors: Sun Kai-Peng , Chen Qiang , Hong Zhi-Nuan , Huang Jiang-Shan , Cao Hua 
Published: October 2019

Abstract

Objective
To evaluate the health-related quality of life (HRQoL) of adult patients who underwent transthoracic device closure of ventricular septal defect (VSD).

Methods
During the perioperative and postoperative period, a standard scale involving eight dimensions was used to analyze the HRQoL of 85 adult patients who underwent thoracic device closure of VSD and 80 healthy adults located locally were randomly selected as the control group in our center.

Results
A total of 80 patients’ and 80 healthy adults’ questionnaires were received with complete feedback. Out of all of the items that were investigated, postoperative patients experienced better feelings in some dimensions than the control group. Postoperative feedback was also better than preoperative feedback in some dimensions. In the comparison of the subgroups of these patients, the scores of the elderly were lower than those of the young in most dimensions. Males had more positive feedback in two aspects (“role-physical” (p = 0.01) and “vitality” (p = 0.003)), whereas unmarried people seemed to have poor emotional responses (“role-emotional” (p < 0.01) and “vitality” (p = 0.023)). There was no significant difference in any dimensions except “social functioning” (p < 0.01) between people with different levels of education.

Conclusions
Most of the adult patients who underwent thoracic closure of VSD felt that they could lead a normal life. They seemed to have reasonably normal psychosocial responses compared to healthy controls. Many patients even though their HRQoL was better than healthy individuals.
Integrative analysis of genetic and epigenetic profiling of lung squamous cell carcinoma (LSCC) patients to identify smoking level relevant biomarkers
Authors: Ma Bidong , Huang Zhiyou , Wang Qian , Zhang Jizhou , Zhou Bin , Wu Jiaohong 
Published: October 2019

Abstract

Background
Incidence and mortality of lung cancer have dramatically decreased during the last decades, yet still approximately 160,000 deaths per year occurred in United States. Smoking intensity, duration, starting age, as well as environmental cofactors including air-pollution, showed strong association with major types of lung cancer. Lung squamous cell carcinoma is a subtype of non-small cell lung cancer, which represents 25% of the cases. Thus, exploring the molecular pathogenic mechanisms of lung squamous cell carcinoma plays crucial roles in lung cancer clinical diagnosis and therapy.

Results
In this study, we performed integrative analyses on 299 comparative datasets of RNA-seq and methylation data, collected from 513 lung squamous cell carcinoma cases in The Cancer Genome Atlas. The data were divided into high and low smoking groups based on smoking intensity (Numbers of packs per year). We identified 1002 significantly up-regulated genes and 534 significantly down-regulated genes, and explored their cellular functions and signaling pathways by bioconductor packages GOseq and KEGG. Global methylation status was analyzed and visualized in circular plot by CIRCOS. RNA-and methylation data were correlatively analyzed, and 24 unique genes were identified, for further investigation of regional CpG sites’ interactive patterns by bioconductor package coMET. AIRE, PENK, and SLC6A3 were the top 3 genes in the high and low smoking groups with significant differences.

Conclusions
Gene functions and DNA methylation patterns of these 24 genes are important and useful in disclosing the differences of gene expression and methylation profiling caused by different smoking levels.
DNA extraction for human microbiome studies: the issue of standardization
Authors: Greathouse K. Leigh , Sinha Rashmi , Vogtmann Emily 
Published: October 2019

Abstract
Among the laboratory and bioinformatic processing steps for human microbiome studies, a lack of consistency in DNA extraction methodologies is hindering the ability to compare results between studies and sometimes leading to errant conclusions. The purpose of this article is to highlight the issues related to DNA extraction methods and to suggest minimum standard requirements that should be followed to ensure consistency and reproducibility.
A cross-sectional survey on sleep quality, mental health, and academic performance among medical students in Saudi Arabia
Authors: Al-Khani Abdullah Murhaf , Sarhandi Muhammad Ishaque , Zaghloul Mohamed Saddik , Ewid Mohammed , Saquib Nazmus 
Published: October 2019

Abstract

Objective
Adequate sleep is integral to better mental health and facilitates students’ learning. We aimed to assess sleep quality among medical students and to see whether it was associated with their mental health (e.g., depression, anxiety, and stress) and academic performance.

Results
A total of 206 responded, and 95 of them had complete data on demography, lifestyle, academic performance, sleep quality (Pittsburgh Sleep Quality Index), and mental health (Depression Anxiety Stress Scales). The prevalence of poor sleep was 63.2%; it was higher among students who were physically inactive and had more screen time. Poor sleepers demonstrated higher academic performance than sufficient sleepers (p = 0.04). The prevalence of depression, anxiety, and stress were 42%, 53%, and 31% respectively. Sleep quality was significantly associated with depression (p = 0. 03), anxiety (p = 0.007), and stress (p = 0.01).
Preliminary development of a questionnaire measuring patient views of participation in clinical trials
Authors: Arnetz Judith , Sudan Sukhesh , Goetz Courtney , Arnetz Bengt , Gowland Laura , Manji Suzanne , Ghosh Samiran 
Published: October 2019

Abstract

Objective
This study aimed to develop a questionnaire for measuring patient perceptions of participating in clinical trials. Development was based on earlier research on patient views of involvement in medical care and a literature review. Patients were recruited from an ongoing clinical trial focused on cardiovascular illness and from an outpatient psychiatry department. Factor analysis was conducted on a pilot version of the questionnaire in 2016 and on a revised version in 2017.

Results
A total of 53 patients were recruited for the pilot study and 55 were recruited for the main study, substantially below the goal of 100 participants. Factor analysis revealed six factors measuring aspects of patients’ perceptions of participating in clinical trials, including motivation, risks and benefits, the nature of the trial itself, and practical considerations, such as cost and convenience. Inter-scale correlations ranged between 0.06 and 0.64, indicating acceptable scale independence. Reliability scores (Cronbach’s alphas) ranged from 0.62 to 0.85. Factor analysis results were somewhat unstable, with shared variance for several items across scales. This is likely due to the small sample sizes. In larger, more diverse patient samples, this questionnaire can be useful for measuring and incorporating patients’ views into the design and execution of clinical trials.
Transfer restless multi-armed bandit policy for energy-efficient heterogeneous cellular network
Authors: Modi Navikkumar , Mary Philippe , Moy Christophe 
Published: October 2019

Abstract
This paper proposes a learning policy to improve the energy efficiency (EE) of heterogeneous cellular networks. The combination of active and inactive base stations (BS) that allows for maximizing EE is identified as a combinatorial learning problem and requires high computational complexity as well as a large signaling overhead. This paper aims at presenting a learning policy that dynamically switches a BS to ON or OFF status in order to follow the traffic load variation during the day. The network traffic load is represented as a Markov decision process, and we propose a modified upper confidence bound algorithm based on restless Markov multi-armed bandit framework for the BS switching operation. Moreover, to cope with initial reward loss and to speed up the convergence of the learning algorithm, the transfer learning concept is adapted to our algorithm in order to benefit from the transferred knowledge observed in historical periods from the same region. Based on our previous work, a convergence theorem is provided for the proposed policy. Extensive simulations demonstrate that the proposed algorithms follow the traffic load variation during the day and contribute to a performance jump-start in EE improvement under various practical traffic load profiles. It also demonstrates that proposed schemes can significantly reduce the total energy consumption of cellular network, e.g., up to 70% potential energy savings based on a real traffic profile.
Stability analysis of discrete-time multi-patch Beddington–DeAngelis type predator-prey model with time-varying delay
Authors: Feng Jiqiang , Zhao Zhiqiang 
Published: October 2019

Abstract
This paper is concerned with the stability of a discrete-time multi-patch Beddington–DeAngelis type predator-prey model with time-varying delay, where the dispersal of both predators and prey is considered. A nonstandard finite difference scheme is used to discretize this model. Then, combining the Lyapunov–Krasovskii method with the graph-theoretical technique, a stability criterion is derived, which is closely related to the dispersal topology. And an example with numerical simulation is given to demonstrate the effectiveness of the obtained results.
A Hysteretic Constitutive Model for Reinforced Concrete Panel Elements
Authors: Orakcal Kutay , Massone Leonardo M. , Ulugtekin Denizhan 
Published: October 2019

Abstract
A simple yet effective constitutive model-referred to as the “Fixed Strut Angle Model” (FSAM)-is presented in this paper for simulating the nonlinear axial/shear behavior of reinforced concrete membrane (panel) elements subjected to generalized and reversed cyclic loading conditions. In the formulation of the FSAM, normal stresses in cracked concrete are calculated along fixed crack (strut) directions. Shear stresses developing along crack surfaces, which are calculated using a simple friction-based constitutive relationship, are superimposed with the concrete stresses along the struts, for obtaining the total stress field in concrete. Model predictions were compared with panel tests results available in the literature, at various global and local response levels. The model was demonstrated to reasonably capture the overall response characteristics of reinforced concrete panels, including hysteretic shear stress vs. strain behavior, shear stress capacity, hysteretic shear stiffness attributes, ductility, pinching behavior, governing failure mode, principal strain and stress directions, and local deformations.