bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncomplicated Acute Calculous Cholecystitis Who Underwent Cholecystectomy
Authors: Muradyan A. A. , Blagovestnov D. A. , Sychev D. A. , Yartsev P. A. , Rogal M. L. , Kerimova L. N. , Koroshvili V. T. , Yepifanova I. A. 
Published: October 2020

Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia. Despite this, applied postoperative analgesia combinations are not devoid of drawbacks, such as lack of effective postoperative analgesia and the presence of side effect. The use of a pharmacogenetic approach to analgesic therapy for the purpose of its personalization may increase the effectiveness and safety of the use of analgesics. In particular, the presence of an inactive CYP2D6*4 allele , in which the conversion of tramadol to its active metabolite is reduced, contributes to the insufficient efficacy of the drug. As for non-steroidal anti-inflammatory drugs, the presence of CYP2C9*2/*3 polymorphisms leads to a decrease in drug metabolism and a longer half-life, resulting in the increase of the clinical effect and the risk of adverse reactions. Thus, genotyping of patients with the determination of the presence of specific genetic factors can rationalize the postoperative analgesia.Aim of study. Evaluation of the possible association of polymorphisms of the CYP2D6 and CYP2C9 genes with the clinical efficacy of tramadol and ketorolac in relation to postoperative pain.Material and methods. This observational clinical study involved 107 patients with uncomplicated acute calculous cholecystitis who underwent videolaparoscopic cholecystectomy and perioperative treatment according to ARP. All patients underwent whole blood sampling followed by real-time polymerase chain reaction genotyping. Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. In CYP2D64* carriers pain was higher than that of wild-type carriers, according to VAS and McGill Pain Questionnaire in all investigated periods. In carriers of CYP2C9*2, the pain syndrome was lower than in carriers of the wild type at all intervals studied. In carriers of CYP2C9*3 pain was lower only after 2 and 6 hours, also according to McGill Pain Questionnaire.Conclusion. 1. The presence of the polymorphic marker CYP2D6*4 may reduce the efficacy of postoperative tramadol analgesia compared with wild type. 2. The presence of the polymorphic marker CYP2C9*2 and CYP2C9*3 may increase the efficacy of ketorolac pain relief compared to wild type.
The Choice of Treatment Tactics in Patients with Severe Acute Pancreatitis Taking Into Account the Factor of Intra-Abdominal Hypertension
Authors: Belik B. M. , Chirkinyan G. M. , Tenchurin R. S. , Abduragimov Z. A. , Mareyev D. V. , Dadayan A. R. , Oskanyan M. A. , Sapraliyev A. R. 
Published: October 2020

Relevance. Increased intra-abdominal pressure (IAP) in patients with severe acute pancreatitis (AP) is one of the triggers for the development of a functional organ failure, which leads to death. In this case, the favorable outcome of treatment of patients with severe AP is largely determined by early diagnosis and timely elimination of intra-abdominal hypertension (IAH). At the same time, there is no unified and agreed opinion on the principles and specific methods of eliminating the IAH syndrome in patients with severe AP today, which greatly complicates the choice of treatment strategy and tactics.Aim of study. To assess the role and clinical significance of IAP monitoring in patients with severe AP with various manifestations of organ dysfunction and, offer a set of therapeutic measures aimed at resolving intra-abdominal hypertension.Material and methods. The current study included 199 patients with severe AP, divided into two groups depending on the chosen treatment strategy. Group I included 107 patients where the diagnosis and treatment of the disease corresponded to generally accepted standards. Group II included 92 patients, where, in order to objectify the severity and prognosis of the course of AP, along with standard studies, IAP and APACHE II scale indicators were additionally monitored during treatment, and the severity of organ dysfunctions was assessed. In these patients the choice of medical tactics, including the use of conservative and surgical interventions, was made on a differentiated basis, based on the severity of the disease and the dynamics of the IAH.Results. The role and significance of IAP monitoring and APACHE II scale indicators in the treatment of patients with severe AP were determined. The use of a differentiated approach to the choice of treatment strategies for patients with AP considering the severity of the disease and severity of IAH syndrome results in reduced hospital mortality by 10.3% and reduced postoperative mortality by 11.4%.Conclusion. Monitoring of intra-abdominal pressure and APACHE II scale indices in conjunction with standard clinical and laboratory parameters allows patients to be clearly stratified according to the severity of acute pancreatitis, which helps optimize the choice of treatment tactics, including methods and timing of surgery, as well as the use of a set of effective therapeutic measures aimed at eliminating intra-abdominal hypertension.
Comparing the efficiency of base and multiplicative selection indices for yield and quality traits in Cassava
Authors: Ntivuguruzwa Severin , Edema R. , Gibson Paul , Alladassi M.E.B. , Nduwumuremyi A. , Abincha W. , Kawuki R. 
Published: October 2020

The efficiency of two selection indices; base index and the multiplicative index was compared to determine the effectiveness of each in identifying superior genotypes in cassava (Manihot esculent Crantz) population. Genotypic data on various yield and quality traits among 570 cassava genotypes were used to construct these selection indices. The efficiency of these indices was compared by determining the performance means of each genotype for studied traits and computing selection differentials of each index. Best linear unbiased predictions (BLUPs) for dry matter content and harvest index were also used for comparison of the two selection indices. The base index produced high-performance means of all five studied traits and proved to be more efficient compared to the multiplicative index in the improvement of cassava genotypes. In addition, the base index produced high selection differentials for three out of five studied traits. It was concluded that the base index is useful in cassava germplasm selection
PENGARUH RENDAM KAKI AIR HANGAT TERHADAP KUALITAS TIDUR PADA LANSIA DI WILAYAH KERJA PUSKESMAS HANDAPHERANG KABUPATEN CIAMIS TAHUN 2019
Authors: Wibowo Daniel Akbar , Purnamasari Laila 
Published: October 2020

Proses menua adalah proses alami yang disertai adanya penurunan kondisi fisik dengan terlihat adanya penurunan fungsi organ tubuh. Proses penuaan membuat lansia lebih mudah mengalami gangguan tidur. Penanganan gangguan tidur dapat dilakukan dengan 2 cara yaitu secara farmakologi dan secara non farmakologi. Penatalaksanaan secara non farmakologi adalah pilihan alternative yang lebih aman, yakni dengan cara rendam kaki air hangat. Manfaat air hangat adalah untuk membuat tubuh lebih rileks, menyingkirkan rasa pegal-pegal dan kaku di otot, dan mengantar agar tidur bisa lebih nyenyak. Peneliti menggunakan metode eksperimen kuasi. Populasi penelitian ini adalah lansia berumur 60-70 tahun sebanyak 30 lansia. Sampel dalam penelitian ini menggunakan total sampling sebanyak 30 lansia yang terdiri dari 15 orang kelompok intervensi dan 15 orang kelompok kontrol. Hasil penelitian menunjukan bahwa sebagian besar lansia pada kelompok Kontrol yaitu memiliki kualitas tidur buruk sebanyak 10 orang (66,7%) sedangkan Kualitas Tidur Kelompok Intervensi setelah Dilakukan Rendam Kaki Air Hangat Pada Lansia sebagian besar reponden memiliki kualitas tidur baik sebanyak 10 orang (66,7%) Berdasarkan hasil uji t-test diperoleh nilai hitung t hitung sebesar 24,261 dari nilai t tabel sebesar 2,624. Dari analisa tersebut bahwa Ha diterima atau ada pengaruh rendam kaki air hangat terhadap kualitas tidur pada lansia di Wilayah Kerja Puskesmas Handapherang Kabupaten Ciamis. Saran diharapkan bagi lansia dapat menjadi bahan pertimbangan untuk lansia untuk memperbaiki kualitas tidur yang buruk dengan cara menghindari kecemasan.
HUBUNGAN KOMUNIKASI TERAPEUTIK PERAWAT DENGAN KEPUASAN PASIEN DI RUANG RAWAT INAP RUMAH SAKIT UMUM DAERAH KABUPATEN CIAMIS TAHUN 2018
Authors: Kurniasih Eli 
Published: October 2020

Individu akan melewati beberapa fase perkembangan yang pada akhirnya mencapai usia lanjut atau lansia (Sunaryo:2004). Relaksasi Progresif yang merupakan terapi berdasarkan hubungan antara ketegangan otot dengan ketegangan emosi. Kecemasan merupakan suatu perasaan subjektif mengenai ketegangan mental yang menggelisahkan sebagai reaksi umum dari ketidakmampuan mengatasi suatu masalah atau tidak adanya rasa aman. Perasaan yang tidak menentu tersebut pada umumnya tidak menyenangkan yang nantinya akan menimbulkan atau disertai perubahan fisiologis dan psikologis (Rochman, 2010:104). Penelitia ini bertujuan mengetahui dampak penerapan terapi komplementer Relaksasi Progresif pada Pasien Lansia dengan gangguan Kecemasan di panti Wredha Welas Asih Tasikmalaya. Penelitian ini menggunakan desain pra eksperimen dengan pra dan post test without control design. Seluruh sampel di cek dulu apakah mengalami kecemasan atau tidak, jika mengalami kecemasan lalu diberikan perlakuan berupa Terapi Relaksasi Progresif, apakah ada penurunan atau peningkatan dari kecemasannya. Hasil penelitian menunjukkan tingkat kecemasan responden yang tidak ada perubahan setelah dilakuan intervensi relaksasi progresif terbanyak yaitu pada tidak ada perubahan sebanyak 19 responden (76%), sedangkan ada perubahan sebanyak 6 responden (24%). Simpulan Diketahui tingkat kecemasan tingkat kecemasan pada lansia di panti wredha Welas Asih Tasikmalaya sebanyak 23 responden atau 92% mengalami kecemasan ringan. Saran yang diberikan kepada Pengelola panti Relaksasi otot sebaiknya dilakukan setiap hari untuk membantu mengurangi ketegangan otot yang berdampak pada penurunan tingkat kecemasan.
Boutevin, C. "Livres de poème(s) et poème(s) en livres pour la jeunesse aujourd’hui". Bordeaux: Presses Universitaires de Bordeaux, 2018, 312 pp.
Authors: Senís Fernández Juan 
Published: October 2020

Reseña de Boutevin, C. Livres de poème(s) et poème(s) en libres pour la jeunesse aujourd’hui. Burdeaus: Presses Universitaires de Bordeaux, 2018, 312pp.
Antimicrobial susceptibility of Neisseria gonorrhoeae in Barcelona during a five-year period, 2013 to 2017
Authors: Salmerón Paula , Viñado Belén , El Ouazzani Rachid , Hernández Marta , Barbera María Jesús , Alberny Mireia , Jané Mireia , Larrosa Nieves , Pumarola Tomás , Hoyos-Mallecot Yannick , Serra-Pladevall Judit 
Published: October 2020

Introduction
Increasing rates of antimicrobial resistance in Neisseria gonorrhoeae cause problems for treating gonorrhoea.

Aim
This observational study aimed to describe isolates from all patients found infected with N. gonorrhoeae, in Barcelona, Spain, between 2013 and 2017, and with available antimicrobial susceptibility data.

Methods
Minimum inhibitory concentrations (MICs) of penicillin (PEN), cefixime (CFM), ceftriaxone (CRO), azithromycin (AZM), ciprofloxacin (CIP), spectinomycin (SPT), fosfomycin (FOF) and gentamicin (GEN) were determined by E-test. Susceptibility was assessed using clinical breakpoints from the European Committee on Antimicrobial Susceptibility Testing. Time trends for PEN, CFM, AZM and CIP were investigated using logistic regression.

Results
Of 1,979 patients with infection (2,036 isolates), 1,888 (95.4%) were men. Patient median age was 32 years. The proportions of isolates resistant to extended-spectrum cephalosporins were low, with 0.3% (5/1,982) resistant to CRO and 4.9% (98/1,985) to CFM. AZM resistance prevalence was 2.7% (52/1,981), including 16 isolates detected in 2016 and 2017, with high-level resistance. For CIP, 51.3% (1,018/1,986) of isolates were resistant, and for PEN, 20.1% (399/1,985). All isolates were susceptible to SPT. MIC50 and MIC90 values of GEN were 4 and 6 mg/L and of FOF 12 and 24 mg/L, respectively. Between 2013 and 2017, PEN and CFM resistance rates each decreased from 28.1% (92/327) to 12.2% (70/572) and from 8.3% (27/327) to 4.4% (25/572) (p ≤ 0.0073). In contrast, AZM resistance prevalence appeared to increase from 1.5% in 2014 (5/340) to 3.0% (17/572) in 2017. No trend was identified for CIP.

Conclusion
Antimicrobial susceptibility surveillance is important to timely detect new phenotypes and trends.
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Authors: Thompson Craig P , Grayson Nicholas E , Paton Robert S , Bolton Jai S , Lourenço José , Penman Bridget S , Lee Lian N , Odon Valerie , Mongkolsapaya Juthathip , Chinnakannan Senthil , Dejnirattisai Wanwisa , Edmans Matthew , Fyfe Alex , Imlach Carol , Kooblall Kreepa , Lim Nicholas , Liu Chang , López-Camacho César , McInally Carol , McNaughton Anna L , Ramamurthy Narayan , Ratcliff Jeremy , Supasa Piyada , Sampson Oliver , Wang Beibei , Mentzer Alexander J , Turner Marc , Semple Malcolm G , Baillie Kenneth ,   ISARIC4C Investigators, Harvala Heli , Screaton Gavin R , Temperton Nigel , Klenerman Paul , Jarvis Lisa M , Gupta Sunetra , Simmonds Peter 
Published: October 2020

Background
The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of blood donors in Scotland in the spring of 2020 to detect neutralising antibodies to SARS-CoV-2 as a marker of past infection and epidemic progression.

Aim
Our objective was to determine if sera from blood bank donors can be used to track the emergence and progression of the SARS-CoV-2 epidemic.

Methods
A pseudotyped SARS-CoV-2 virus microneutralisation assay was used to detect neutralising antibodies to SARS-CoV-2. The study comprised samples from 3,500 blood donors collected in Scotland between 17 March and 18 May 2020. Controls were collected from 100 donors in Scotland during 2019.

Results
All samples collected on 17 March 2020 (n = 500) were negative in the pseudotyped SARS-CoV-2 virus microneutralisation assay. Neutralising antibodies were detected in six of 500 donors from 23 to 26 March. The number of samples containing neutralising antibodies did not significantly rise after 5–6 April until the end of the study on 18 May. We found that infections were concentrated in certain postcodes, indicating that outbreaks of infection were extremely localised. In contrast, other areas remained comparatively untouched by the epidemic.

Conclusion
Although blood donors are not representative of the overall population, we demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.
Farklı Lokasyonlarda Yetiştirilen Kuru Fasulye Genotiplerinin (Phaseolus Vulgaris L.) Bazı Kalite Özelliklerinin Belirlenmesi Üzerine Bir Araştırma
Authors: SÖZEN Ömer , KARADAVUT Ufuk 
Published: October 2020

Yürütülen araştırma, 4’ü kuru fasulye çeşidi (Zülbiye, Yunus 90, Göynük 98 ve Önceler 98) ile 26’sı ileri düzey kuru fasulye hattı olmak üzere toplam 30 kuru fasulye genotipinin 2018 yılında Samsun ve Kırşehir ekolojik koşullarında bazı kalite parametreleri(kuru ağırlık, yaş ağırlık, su alma kapasitesi, su alma indeksi, şişme kapasitesi, şişme indeksi, kabuk oranı ve protein oranı) bakımından karşılaştırılması amacıyla yürütülmüştür. Araştırma, tesadüf blokları deneme deseninde dört tekrarlamalı olarak kurulmuştur. Araştırmada iki lokasyonun ortalamasına göre en yüksek kuru ağırlık 46.89 g ile KIR/2013/01, en yüksek protein verimi %22.27 ile G.K.2009/327 genotiplerinden ve en yüksek kabuk oranı ise %8.5 ile Önceler 98 kuru fasulye çeşidinden elde edilmiştir.
Araştırma sonucunda teknolojik özellikler bakımından Kelkit Vadisi, Karadeniz Bölgesi, Artvin ile Kırşehir illerinden toplanarak ileri düzeye kadar getirilen G.K.2010/28, K.1121, K.1133, G.K.2009/327 ve KIR/2013/01 nolu genotiplere ait kalite performanslarının diğer genotiplere nazaran daha yüksek oldukları tespit edilmiştir.
Evaluasi Kebijakan Pemerintah Pasca Bencana (Studi Kasus Bencana di Sulawesi Tengah)
Authors: Samad Ahsan , Erdiansyah Erdiansyah , Wulandari Rina 
Published: October 2020

The purpose of this study is to identify and describe the impact and behavior of the community on post-disaster economic conditions in the city of Palu and to know the local government's public policies in handling these cases. Using qualitative methods with a case study approach, literature study, and secondary data processing from various social elements. In addition, data collection was carried out by interviewing informants who felt the direct impact of the earthquake, tsunami and liquefaction in Palu, Sigi and Donggala. The results showed that the post-disaster impact felt by the people of Palu City was generally in the "severe" classification. The socio-economic conditions of the people of Palu include several aspects, ranging from the geographical conditions that are in disaster-prone zones, to the extremely poor health conditions after the disaster. The conclusion of this research shows that the escalation of natural disasters in the city of Palu is considered quite large because it consists of three types of disasters, namely the Earthquake, Tsunami and Liquifation in the same time period. Palu City is the capital of the Province as well as the economic and administrative center of Central Sulawesi Province. Damage to warehousing infrastructure coupled with massive looting from unscrupulous people in logistics supply warehouses resulted in goods that were supposed to be distributed both to the city and the district finally unable to be implemented.Tujuan penelitian ini yaitu mengidentifikasi dan mendeskripsikan evaluasi dampak dan perilaku masyarakat terhadap kondisi perekonomian pasca bencana di kota Palu dan mengetahui kebijakan publik pemerintah setempat dalam menangani kasus tersebut. Menggunakan metode kualitatif dengan pendekatan studi kasus, studi literature, dan pengolahan data sekunder dari berbagai elemen sosial. Selain itu pengambilan data dilakukan dengan cara wawacara kepada narasumber yang merasakan dampak langsung dari bencana gempa,tsunami dan likuifaksi di Palu,Sigi dan Donggala. Hasil penelitian memperlihatkan bahwa dampak pasca bencana yang dirasakan oleh masyarakat Kota Palu secara umum berada pada klasifikasi “berat”. Kondisi sosial ekonomi masyarakat kota Palu meliputi beberapa aspek, mulai dari kondisi geografis yang berada pada zona rawan bencana, kondisi kesehatan sangat memprihatinkan pasca bencana. Kesimpulan penelitain ini menujukkan bahwa eskalasi bencana alam kota Palu dinilai cukup besar karena terdiri dari tiga macam bencana yaitu Gempa Bumi, Tsunami dan Liquifasi dalam kurun waktu sama. Kota Palu merupakan ibukota Provinsi sekaligus sebagai pusat ekonomi dan pemerintahan Provinsi Sulawesi Tengah. Rusaknya infrakstruktur pergudangan ditambah dengan adanya penjarahan yang massiv dari oknum masyarakat pada gudang-gudang suplai logistik mengakibatkan barang yang semestinya didistribusikan baik ke kota ataupun ke kabupaten akhirnya tidak dapat dilaksanakan.
PERANAN SITUS SEJARAH DERMAGA SENG HIE BAGI MASYARAKAT KOTA PONTIANAK
Authors: Wulandari F. Sri Dewi 
Published: October 2020

<p align="center"><strong>Abstrak</strong></p><p>Penelitian ini bertujuan untuk mengetahui sejarah Dermaga Seng Hie, Fungsi Dermaga Seng Hie, dan Eksistensi Dermaga Seng Hie dimasa sekarang. Penelitian ini menggunakan metode Kualitatif. Hasil penelitian menujukan Dermaga Seng Hie sebagai Dermaga tertua yang ada di Kota Pontianak dan didirikan oleh seorang keturunan Cina bernama Tan Sheng Hie sekaligus sebagai pengusaha hasil bumi. Dermaga Seng Hie dijadikan sebagi tempat bongkar muat barang terutama barang komoditi masyarakat. Dermaga seng hie sebagai dermaga pertama di kota pontianak sebagai jalur pendistribusian barang-barang tetap digunakan hingga sekarang.</p><p> </p><p><strong>Kata Kunci:</strong> Dermaga Seng Hie; situs sejarah; Pontianak;</p><p> </p><p align="center"><strong><em>Abstract</em></strong></p><p><em>This study aims to determine the history of the Seng Hie Pier, the function of the Seng Hie Pier, and the existence of the Seng Hie Pier in the present day. This study uses a qualitative method. The results of the study address the Seng Hie Pier as the oldest Pier in the City of Pontianak and was founded by a Chinese descent named Tan Sheng Hie as well as a crop entrepreneur. Seng Hie's dock is used as a loading and unloading place for goods, especially for community commodity goods. Seng hie dock as the first pier in the city of Pontianak as a path for the distribution of goods is still in use today.</em></p><p><em> </em></p><strong><em>Keywords:</em></strong><em> Dermaga Seng Hie; historical site; Pontianak;</em>
Helicobacter pilory en niños con enfermedad celiaca. Hallazgos epidemiológicos y clínicos
Authors: Couchonal Eduardo , Corrales Bernardita , Garcete Lidia 
Published: October 2020

Introducción: En países en desarrollo se describen prevalencias de Helicobacter pylory (HP) de hasta 80%. Su impacto en los enfermos celiacos es controversial, pero existen indicios que podría agravar la condición celiaca. No se ha confirmado la asociación entre ambas. En nuestro medio, factores socio ambientales pudieran favorecer una elevada prevalencia del HP. Objetivos: Conocer la prevalencia de infección por HP en una población pediátrica portadora de enfermedad celiaca (EC). Materiales y Métodos: estudio observacional, retrospectivo de corte transversal revisando fichas clínicas y resultados biópsicos de pacientes sometidos a endoscopia digestiva alta por la sospecha clínica y laboratorial (marcadores serológicos positivos) de enfermedad celiaca en el Departamento de Gastroenterología del Servicio de Pediatría del Hospital de Clínicas de la Facultad de Ciencias Médicas.
Resultados: Se incluyeron en el estudio 50 muestras de biopsias gástricas y duodenales. Todos reunieron criterios histológicos de EC, en 9 pacientes (18%) se observó la presencia de HP. No se encontraron diferencias significativas en aspectos socioambientales y tampoco en cuanto a prevalencia de desnutrición y anemia comparando EC con y sin HP. Llamo la atención la presencia de distensión abdominal como dato significativo en los EC portadores de HP. La gastritis crónica activa fue el hallazgo histológico prevalente (89%) en los EC con HP+.
Conclusión: La prevalencia de HP en niños celiacos fue del 18%, inferior al esperado, aunque coincidente con un reporte nacional previo.
Correspondencia: Lidia Garcete Correo: lidiga1@hotmail.com

Conflicto de interés: Los autores declaran no poseer conflicto de interés.

Recibido: 26/08/2020 Aceptado: 28/09/2020