bluuebunny/crossref_metadata_2025_split huggingface dataset:
A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent
Authors: Lawrence Colleen E. , Dunkel Leah , McEver Mark , Israel Tiffany , Taylor Robert , Chiriboga Germán , Goins Karin Valentine , Rahn Elizabeth J. , Mudano Amy S. , Roberson Erik D. , Chambless Carol , Wadley Virginia G. , Danila Maria I. , Fischer Melissa A. , Joosten Yvonne , Saag Kenneth G. , Allison Jeroan J. , Lemon Stephenie C. , Harris Paul A. 
Published: April 2020

AbstractIntroduction:The updated common rule, for human subjects research, requires that consents “begin with a ‘concise and focused’ presentation of the key information that will most likely help someone make a decision about whether to participate in a study” (Menikoff, Kaneshiro, Pritchard. The New England Journal of Medicine. 2017; 376(7): 613–615.). We utilized a community-engaged technology development approach to inform feature options within the REDCap software platform centered around collection and storage of electronic consent (eConsent) to address issues of transparency, clinical trial efficiency, and regulatory compliance for informed consent (Harris, et al. Journal of Biomedical Informatics 2009; 42(2): 377–381.). eConsent may also improve recruitment and retention in clinical research studies by addressing: (1) barriers for accessing rural populations by facilitating remote consent and (2) cultural and literacy barriers by including optional explanatory material (e.g., defining terms by hovering over them with the cursor) or the choice of displaying different videos/images based on participant’s race, ethnicity, or educational level (Phillippi, et al. Journal of Obstetric, Gynecologic, & Neonatal Nursing. 2018; 47(4): 529–534.).Methods:We developed and pilot tested our eConsent framework to provide a personalized consent experience whereby users are guided through a consent document that utilizes avatars, contextual glossary information supplements, and videos, to facilitate communication of information.Results:The eConsent framework includes a portfolio of eight features, reviewed by community stakeholders, and tested at two academic medical centers.Conclusions:Early adoption and utilization of this eConsent framework have demonstrated acceptability. Next steps will emphasize testing efficacy of features to improve participant engagement with the consent process.
Case Report on Early Diagnosis of COVID-19
Authors: Zhou Yang , Yang Le , Han Ming , Huang Minqiang , Sun Xuedong , Zheng Weidong , Han Wei , Wang Jinhong 
Published: April 2020

ABSTRACTThe coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, spread rapidly throughout China and gradually to some countries abroad. How is the development of an epidemic controlled? Early diagnosis is one of the important contents in prevention and control. COVID-19 patients with early mild pneumonia often lack typical evidence to make a definitive diagnosis. Based on the analysis of the cases of 4 patients, this article finds that early diagnosis requires a combination of epidemiology, clinical manifestations, imaging, and etiology, with particular emphasis on epidemiology history and chest computed tomography (CT) manifestations.
The Macedonian “Name” Dispute: The Macedonian Question—Resolved?
Authors: Nimetz Matthew 
Published: April 2020

AbstractThe dispute between Greece and the newly formed state referred to as the “Former Yugoslav Republic of Macedonia” that emerged out of the collapse of Yugoslavia in 1991 was a major source of instability in the Western Balkans for more than 25 years. It was resolved through negotiations between Athens and Skopje, mediated by the United Nations, resulting in the Prespa (or Prespes) Agreement, which was signed on June 17, 2018, and ratified by both parliaments amid controversy in their countries. The underlying issues involved deeply held and differing views relating to national identity, history, and the future of the region, which were resolved through a change in the name of the new state and various agreements as to identity issues. The author, the United Nations mediator in the dispute for 20 years and previously the United States presidential envoy with reference to the dispute, describes the basis of the dispute, the positions of the parties, and the factors that led to a successful resolution.
Eating game: proteins, international conservation and the rebranding of African wildlife, 1955–1965
Authors: DE BONT RAF 
Published: April 2020

AbstractAround 1960, leading figures in the international conservation circuit – such as Julian Huxley, Frank Fraser Darling and E. Barton Worthington – successfully propagated new visions about the value of undomesticated African mammals. Against traditional ideas, they presented these mammals as a highly efficient source of protein for growing African populations. In line with this vision, they challenged non-interventionist ideals of nature preservation, and launched proposals for active management through game ‘ranching’ and ‘cropping’. As such, they created a new socio-technical imaginary for Africa's future, in which the consumption of wildlife meat took up a central position. This article explores the motivations of Western conservationists for this drastic rebranding. It argues that the rationale of considering African wildlife in terms of protein played an important symbolical role at various levels. It was crucial in the reorganization of the transnational networks of conservation, but also in the boosting of their scientific reputation, in the restructuring of their institutional ties, and in their attempts to maintain an authoritative position for Western ecologists in a rapidly decolonizing world.
Physiological changes in the size of the septal swell body correlate with changes in inferior turbinate size
Authors: Wong E H , Noussair M , Hasan Z , Duvnjak M , Singh N 
Published: April 2020

AbstractObjectiveThe nasal septal swell body is a normal anatomical structure located in the superior nasal septum anterior to the middle turbinate. However, the impact of the septal swell body in nasal breathing during normal function and disease remains unclear. This study aimed to establish that the septal swell body varies in size over time and correlates this with the natural variation of the inferior turbinates.MethodConsecutive patients who underwent at least two computed tomography scans were identified. The width and height of the septal swell body and the inferior turbinates was recorded. A correlation between the difference in septal swell body and turbinates between the two scans was performed using a Pearson's coefficient.ResultsA total of 34 patients (53 per cent female with a mean age of 58.3 ± 20.2 years) were included. The mean and mean difference in septal swell body width between scans for the same patient was 1.57 ± 1.00 mm. The mean difference in turbinate width between scans was 2.23 ± 2.52 mm. A statistically significant correlation was identified between the difference in septal swell body and total turbinate width (r = 0.35, p = 0.04).ConclusionThe septal swell body is a dynamic structure that varies in width over time in close correlation to the inferior turbinates. Further research is required to quantify its relevance as a surgical area of interest.
Fault, knowledge and risk within the framework of positive obligations under the European Convention on Human Rights
Authors: Stoyanova Vladislava 
Published: April 2020

AbstractThe European Court of Human Rights has consistently reiterated that positive obligations under the European Convention on Human Rights arise when state authorities knoworought to have known about the risk of harm. This article attempts to describe and assess the role of state knowledge in the framework of positive obligations, and to situate the Court’s approach to knowledge about risk within an intelligible framework of analysis. The main argument is that the assessment of state knowledge is imbued with normative considerations. The assessment of whether the state ‘ought to have known’ is intertwined with, first, concerns that positive obligations should not impose unreasonable burden on the state and, second, the establishment of causal links between state omissions and harm.
Investigating translated Chinese and its variants using machine learning
Authors: Hu Hai , Kübler Sandra 
Published: April 2020

AbstractTranslations are generally assumed to share universal features that distinguish them from texts that are originally written in the same language. Thus, we can argue that these translations constitute their own variety of a language, often called translationese. However, translations are also influenced by their source languages and thus show different characteristics depending on the source language. Consequently, we argue that these variants constitute different “dialects” of translations into the same target language. Studies using machine learning techniques on Indo-European languages have investigated the universal characteristics of translationese and how translations from various source languages differ. However, for typologically very different languages such as Chinese, there are only few corpus studies that tap into the intricate relation between translations and the originals, as well as into the relations among translations themselves. In this contribution, we investigate the following questions: (1) What are the characteristics of Chinese translationese, both in general and with respect to different source languages? (2) Can we find differences not only at the lexical but also on the syntactic level? and (3) Based on the characteristics found in the previous questions, which of the proposed laws and universals can we corroborate based on our evidence from Chinese? We use machine learning to operationalize determining the importance of different characteristics and comparing their importance for our Chinese dataset with characteristics previously reported in studies on English. In addition, our methodology allows us to add syntactic features, which have rarely been used to study translations into Chinese. Our results show that Chinese translations as a whole can be reliably distinguished from non-translations, even based on only five features. More interestingly, typological traces from the source languages can often be found in their translations, therefore creating what we call dialects of translationese. For instance, translations from two Altaic languages exhibit more noun repetition and less frequent use of pronouns. Additionally, some characteristics that are not discriminative for English work well for Chinese, possibly because the distance between Chinese and the source languages is greater than that in English studies.
Combined Anastrozole and Antiplatelet Therapy Treatment Differentially Promotes Breast Cancer Cell Survival
Authors: Xulu Kutlwano , Duarte Raquel , Augustine Tanya 
Published: April 2020

AbstractThromboembolic disorders are the second leading cause of death in breast cancer. Antiplatelet therapy combined with cancer therapy is a potential treatment strategy against cancer-associated thromboembolic disorders; however, the efficacy of such dual treatment has not been established. This study reports novel findings on the response of hormone-dependent breast cancer cell lines (MCF7/T47D) following 24 h treatment with Anastrozole, combined with Aspirin and Clopidogrel cocktail; and Atopaxar. Neutral red and lactate dehydrogenase assays were conducted to assess viability and cytotoxicity respectively. Flow cytometric Annexin-V/PI assay was used to assess the mode of cell death. Morphological alterations were studied using scanning electron microscopy. Statistical analysis was conducted using Statistica V13. Definitive outcomes were established with flow cytometric detection of phosphatidylserine exposure and propidium iodide staining, complemented with ultrastructural analysis. Results showed that a few cells were undergoing death mainly through secondary necrosis. Morphological features suggesting induced cell motility (pseudopodia/ruffled membranes) were observed in both cell lines; notably, T47D cells presented pronounced features than MCF7 cells. Overall, these findings suggest that such combined treatment may differentially promote cell survival, inducing a more aggressive breast cancer phenotype.
Direct Observation of the Surface Topography at High Temperature with SEM
Authors: Podor Renaud , Le Goff Xavier , Lautru Joseph , Brau Henri-Pierre , Barreau Mathias , Carrier Xavier , Mendonça Jerôme , Nogues Dorian , Candeias Antoine 
Published: April 2020

AbstractHigh-temperature scanning electron microscopy allows the direct study of the temperature behavior of materials. Using a newly developed heating stage, tilted images series were recorded at high temperature and 3D images of the sample surface were reconstructed. By combining 3D images recorded at different temperatures, the variations of material roughness can be accurately described and associated with local changes in the topography of the sample surface.
Association between mercury in cord serum and sex-specific DNA methylation in cord tissues
Authors: Nishizawa-Jotaki Shino , Sakurai Kenichi , Eguchi Akifumi , Tanabe Hiromi , Watanabe Masahiro , Mori Chisato 
Published: April 2020

AbstractPrenatal exposure to mercuryin uterocauses abnormal foetal growth and adverse outcomes. DNA methylation is currently considered a possible mechanism through which this occurs. However, few studies have investigated the association between prenatal exposure to mercury and DNA methylation in detail. This study aimed to clarify the relationship between prenatal exposure to total mercury (Hg) and DNA methylation and its associations with sex-specific characteristics in male and female offspring. In a birth cohort study known as the Chiba study of Mother and Child Health, the DNA methylation status in cord tissue and Hg concentrations in cord serum were examined. A total of 67 participants (27 males and 40 females) were analysed based on Spearmanʼs correlations, adjusted by a false discovery rate of the sex of each offspring. Only one methylated locus was positively correlated with Hg concentrations in cord serum in male offspring, but not in female offspring, and was annotated to the haloacid dehalogenase-like hydrolase domain-containing protein 1 (HDHD1) gene on chromosome X. This locus was located in the intron of theHDHD1gene body and is a binding site for the zinc finger protein CCCTC-binding factor. One of the other loci, located inHDHD1, was highly methylated in the group with higher mercury concentrations, and this locus was in the gene body ofHDHD1. Our results suggest that prenatal exposure to Hg might affect the epigenetic status of male foetuses.
Treatment and unmet needs in steroid-refractory acute graft-versus-host disease
Authors: Malard Florent , Huang Xiao-Jun , Sim Joycelyn P. Y. 
Published: April 2020

AbstractAcute graft-versus-host disease (aGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (alloHCT) and is a major cause of morbidity and mortality. Systemic steroid therapy is the first-line treatment for aGVHD, although about half of patients will become refractory to treatment. As the number of patients undergoing alloHCT increases, developing safe and effective treatments for aGVHD will become increasingly important, especially for those whose disease becomes refractory to systemic steroid therapy. This paper reviews current treatment options for patients with steroid-refractory aGVHD and discusses data from recently published clinical studies to outline emerging therapeutic strategies.
In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair
Authors: Peissert Stefan , Sauer Florian , Grabarczyk Daniel B. , Braun Cathy , Sander Gudrun , Poterszman Arnaud , Egly Jean-Marc , Kuper Jochen , Kisker Caroline 
Published: April 2020

AbstractThe XPD helicase is a central component of the general transcription factor TFIIH which plays major roles in transcription and nucleotide excision repair (NER). Here we present the high-resolution crystal structure of the Arch domain of XPD with its interaction partner MAT1, a central component of the CDK activating kinase complex. The analysis of the interface led to the identification of amino acid residues that are crucial for the MAT1-XPD interaction. More importantly, mutagenesis of the Arch domain revealed that these residues are essential for the regulation of (i) NER activity by either impairing XPD helicase activity or the interaction of XPD with XPG; (ii) the phosphorylation of the RNA polymerase II and RNA synthesis. Our results reveal how MAT1 shields these functionally important residues thereby providing insights into how XPD is regulated by MAT1 and defining the Arch domain as a major mechanistic player within the XPD scaffold.
Optogenetic restoration of retinal ganglion cell activity in the living primate
Authors: McGregor Juliette E. , Godat Tyler , Dhakal Kamal R. , Parkins Keith , Strazzeri Jennifer M. , Bateman Brittany A. , Fischer William S. , Williams David R. , Merigan William H. 
Published: April 2020

AbstractOptogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light sensitivity has been irreversibly lost. We combine adaptive optics ophthalmoscopy with calcium imaging to optically record optogenetically restored retinal ganglion cell activity in the fovea of the living primate. Recording from the intact eye of a living animal, we compare the patterns of activity evoked by the optogenetic actuator ChrimsonR with natural photoreceptor mediated stimulation in the same retinal ganglion cells. Optogenetic responses are recorded more than one year following administration of the therapy and two weeks after acute loss of photoreceptor input in the living animal. This in vivo imaging approach could be paired with any therapy to minimize the number of primates required to evaluate restored activity on the retinal level, while maximizing translational benefit by using an appropriate pre-clinical model of the human visual system.
RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
Authors: Casanova-Acebes María , Menéndez-Gutiérrez María Piedad , Porcuna Jesús , Álvarez-Errico Damiana , Lavin Yonit , García Ana , Kobayashi Soma , Le Berichel Jessica , Núñez Vanessa , Were Felipe , Jiménez-Carretero Daniel , Sánchez-Cabo Fátima , Merad Miriam , Ricote Mercedes 
Published: April 2020

AbstractTissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes.
Large non-thermal contribution to picosecond strain pulse generation using the photo-induced phase transition in VO2
Authors: Mogunov Iaroslav A. , Lysenko Sergiy , Fedianin Anatolii E. , Fernández Félix E. , Rúa Armando , Kent Anthony J. , Akimov Andrey V. , Kalashnikova Alexandra M. 
Published: April 2020

AbstractPicosecond strain pulses are a versatile tool for investigation of mechanical properties of meso- and nano-scale objects with high temporal and spatial resolutions. Generation of such pulses is traditionally realized via ultrafast laser excitation of a light-to-strain transducer involving thermoelastic, deformation potential, or inverse piezoelectric effects. These approaches unavoidably lead to heat dissipation and a temperature rise, which can modify delicate specimens, like biological tissues, and ultimately destroy the transducer itself limiting the amplitude of generated picosecond strain. Here we propose a non-thermal mechanism for generating picosecond strain pulses via ultrafast photo-induced first-order phase transitions (PIPTs). We perform experiments on vanadium dioxide VO2 films, which exhibit a first-order PIPT accompanied by a lattice change. We demonstrate that during femtosecond optical excitation of VO2 the PIPT alone contributes to ultrafast expansion of this material as large as 0.45%, which is not accompanied by heat dissipation, and, for excitation density of 8 mJ cm−2, exceeds the contribution from thermoelastic effect by a factor of five.
Origins of fast diffusion of water dimers on surfaces
Authors: Fang Wei , Chen Ji , Pedevilla Philipp , Li Xin-Zheng , Richardson Jeremy O. , Michaelides Angelos 
Published: April 2020

AbstractThe diffusion of water molecules and clusters across the surfaces of materials is important to a wide range of processes. Interestingly, experiments have shown that on certain substrates, water dimers can diffuse more rapidly than water monomers. Whilst explanations for anomalously fast diffusion have been presented for specific systems, the general underlying physical principles are not yet established. We investigate this through a systematic ab initio study of water monomer and dimer diffusion on a range of surfaces. Calculations reveal different mechanisms for fast water dimer diffusion, which is found to be more widespread than previously anticipated. The key factors affecting diffusion are the balance of water-water versus water-surface bonding and the ease with which hydrogen-bond exchange can occur (either through a classical over-the-barrier process or through quantum-mechanical tunnelling). We anticipate that the insights gained will be useful for understanding future experiments on the diffusion and clustering of hydrogen-bonded adsorbates.
The critical role of humidity in modeling summer electricity demand across the United States
Authors: Maia-Silva Debora , Kumar Rohini , Nateghi Roshanak 
Published: April 2020

AbstractCooling demand is projected to increase under climate change. However, most of the existing projections are based on rising air temperatures alone, ignoring that rising temperatures are associated with increased humidity; a lethal combination that could significantly increase morbidity and mortality rates during extreme heat events. We bridge this gap by identifying the key measures of heat stress, considering both air temperature and near-surface humidity, in characterizing the climate sensitivity of electricity demand at a national scale. Here we show that in many of the high energy consuming states, such as California and Texas, projections based on air temperature alone underestimates cooling demand by as much as 10–15% under both present and future climate scenarios. Our results establish that air temperature is a necessary but not sufficient variable for adequately characterizing the climate sensitivity of cooling load, and that near-surface humidity plays an equally important role.