bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Affecting Disruption of Navel Orangeworm (Lepidoptera: Pyralidae) Using Aerosol Dispensers
Authors: Burks Charles S , Thomson Donald R 
Published: January 2020

Abstract
Mating disruption is used to help manage the navel orangeworm on approximately 200,000 ha of tree nut crops. Aerosol dispensers are the most common formulation, and all formulations use an incomplete pheromone blend consisting solely of (Z11,Z13)-hexadecadienal. Profile analysis (examination of capture and males in pheromone traps as a function of spatial density of dispensers) demonstrated a sharp drop of males captured with a very low density of dispensers, and then an approximately linear relationship between 90 and approaching 100% suppression. This near-linear portion of the profile includes both dispenser densities in which crop protection has been demonstrated, and densities in which it is unlikely. Suppression of males in pheromone traps was lost the next night after dispensers were removed, suggesting that the active ingredient was not persistent in the orchard environment. During most of the summer preharvest period, turning the dispensers off 1 or 2 h before the end of the predawn period of sexual activity provides the same amount of suppression of sexual communication as emission throughout the period of sexual activity. This suggests that encountering the pheromone from the mating disruption dispensers had a persistent effect on males. During the autumn postharvest period, only emission prior to midnight suppressed communication on nights on which the temperature fell below 19°C by midnight. These findings and the analysis will help manufacturers refine their offerings for mating disruption for this important California pest, and buyers of mating disruption to assess cost-effectiveness of competing offerings.
Psychosocial-Adjustment Needs of North Korean Refugee Youth from the Perspectives of Alternative-School Members
Authors: Myeong Hwayeon , Lee Ahlam , Park Eun-A , Gong Yea Eun , Kim MiHyang , Jo Hyunjung 
Published: January 2020

Abstract
Research has shown that North Korean refugee (NKR) youth who defected to South Korea are at high risk for multiple psychosocial-adjustment problems. However, little is known about the perceptions of these difficulties on the part of alternative-school community members who interact with them on a daily basis, although such perceptions could provide a rich description of the cultural and environmental aspects associated with these issues. Using a rapid ethnographic assessment, this study explored NKR youth’s psychosocial-adjustment needs from the perspectives of community members of alternative schools that offer NKR students not only education, but food, housing and 24-hour care without charge. Twenty-seven free listing interviews identified that NKR students suffer from three major psychosocial issues: (a) not feeling loved/lack of affection, (b) identity confusion and (c) communication issues/language difficulties. The subsequent seven key informant interviews revealed the perceived symptoms, causes and effects of the psychosocial issues identified and strategies used to cope with them.
The first Doppler imaging of the active binary prototype RS Canum Venaticorum
Authors: Xiang Yue , Gu Shenghong , Wolter U , Schmitt J H M M , Cameron A Collier , Barnes J R , Mittag M , Perdelwitz V , Kohl S 
Published: January 2020

ABSTRACT
We present the first Doppler images of the prototypical active binary star RS Canum Venaticorum, derived from high-resolution spectra observed in 2004, 2016 and 2017, using three different telescopes and observing sites. We apply the least-squares deconvolution technique to all observed spectra to obtain high signal-to-noise line profiles, which are used to derive the surface images of the active K-type component. Our images show a complex spot pattern on the K star, distributed widely in longitude. All star-spots revealed by our Doppler images are located below a latitude of about 70°. In accordance with previous light-curve modelling studies, we find no indication of a polar spot on the K star. Using Doppler images derived from two consecutive rotational cycles, we estimate a surface differential rotation rate of ΔΩ = −0.039 ± 0.003 rad d−1 and α = ΔΩ/Ωeq = −0.030 ± 0.002 for the K star. Given the limited phase coverage during those two rotations, the uncertainty of our differential rotation estimate is presumably higher.
Detectability of embedded protoplanets from hydrodynamical simulations
Authors: Sanchis E , Picogna G , Ercolano B , Testi L , Rosotti G 
Published: January 2020

ABSTRACT
We predict magnitudes for young planets embedded in transition discs, still affected by extinction due to material in the disc. We focus on Jupiter-sized planets at a late stage of their formation, when the planet has carved a deep gap in the gas and dust distributions and the disc starts to being transparent to the planet flux in the infrared (IR). Column densities are estimated by means of three-dimensional hydrodynamical models, performed for several planet masses. Expected magnitudes are obtained by using typical extinction properties of the disc material and evolutionary models of giant planets. For the simulated cases located at 5.2 au in a disc with a local unperturbed surface density of 127 $\mathrm{g} \, \mathrm{cm}^{-2}$, a 1MJ planet is highly extinct in the J, H, and Kbands, with predicted absolute magnitudes ≥ 50 mag. In the L and Mbands, extinction decreases, with planet magnitudes between 25 and 35 mag. In the Nband, due to the silicate feature on the dust opacities, the expected magnitude increases to ∼40 mag. For a 2MJ planet, the magnitudes in the J, H, and Kbands are above 22 mag, while for the L, M, and Nbands, the planet magnitudes are between 15 and 20 mag. For the 5MJ planet, extinction does not play a role in any IR band, due to its ability to open deep gaps. Contrast curves are derived for the transition discs in CQ Tau, PDS 70, HL Tau, TW Hya, and HD 163296. Planet mass upper limits are estimated for the known gaps in the last two systems.
On the origin of the peak of the stellar initial mass function: exploring the tidal screening theory
Authors: Colman Tine , Teyssier Romain 
Published: January 2020

ABSTRACT
Classical theories for the stellar initial mass function (IMF) predict a peak mass that scales with the properties of the molecular cloud. In this work, we explore a new theory proposed by Lee and Hennebelle. The idea is that the tidal field around first Larson cores prevents the formation of other collapsing clumps within a certain radius. The protostar can then freely accrete the gas within this radius. This leads to a peak mass of roughly $10 \, M_{\mathrm{1LC}}$, independent of the parent cloud properties. Using simple analytical arguments, we derive a collapse condition for clumps located close to a protostar. We then study the tidal field and the corresponding collapse condition using a series of hydrodynamic simulations with self-gravity. We find that the tidal field around protostars is indeed strong enough to prevent clumps from collapsing unless they have high enough densities. For each newly formed protostar, we determine the region in which tidal screening is dominant. We call this the tidal bubble. The mass within this bubble is our estimate for the final mass of the star. Using this formalism, we are able to construct a very good prediction for the final IMF in our simulations. Not only do we correctly predict the peak, but we are also able to reproduce the high- and low-mass ends. We conclude that tidal forces are important in determining the final mass of a star and might be the dominant effect in setting the peak mass of the IMF.
Searching for super-Eddington quasars using a photon trapping accretion disc model
Authors: Pognan Quentin , Trakhtenbrot Benny , Sbarrato Tullia , Schawinski Kevin , Bertemes Caroline 
Published: January 2020

ABSTRACT
Accretion on to black holes at rates above the Eddington limit has long been discussed in the context of supermassive black hole (SMBH) formation and evolution, providing a possible explanation for the presence of massive quasars at high redshifts (z ≳ 7), as well as having implications for SMBH growth at later epochs. However, it is currently unclear whether such ‘super-Eddington’ accretion occurs in SMBHs at all, how common it is, or whether every SMBH may experience it. In this work, we investigate the observational consequences of a simplistic model for super-Eddington accretion flows – an optically thick, geometrically thin accretion disc where the inner-most parts experience severe photon-trapping, which is enhanced with increased accretion rate. The resulting spectral energy distributions (SEDs) show a dramatic lack of rest-frame UV, or even optical, photons. Using a grid of model SEDs spanning a wide range in parameter space (including SMBH mass and accretion rate), we find that large optical quasar surveys (such as SDSS) may be missing most of these luminous systems. We then propose a set of colour selection criteria across optical and infrared colour spaces designed to select super-Eddington SEDs in both wide-field surveys (e.g. using SDSS, 2MASS, and WISE) and deep and narrow-field surveys (e.g. COSMOS). The proposed selection criteria are a necessary first step in establishing the relevance of advection-affected super-Eddington accretion on to SMBHs at early cosmic epochs.
Gamma-ray observations of low-luminosity active galactic nuclei
Authors: de Menezes Raniere , Nemmen Rodrigo , Finke Justin D , Almeida Ivan , Rani Bindu 
Published: January 2020

ABSTRACTThe majority of the activity around nearby (z ≈ 0) supermassive black holes is found in low-luminosity active galactic nuclei (LLAGN), the most of them being classified as low-ionization nuclear emission regions. Although these sources are well studied from radio up to X-rays, they are poorly understood in γ-rays. In this work, we take advantage of the all sky-surveying capabilities of the Large Area Telescope on board Fermi Gamma-ray Space Telescope to study the whole Palomar sample of LLAGN in γ-rays. Precisely, the four radio-brightest LLAGN in the sample are identified as significant γ-ray emitters, all of which are recognized as powerful Fanaroff–Riley I galaxies. These results suggest that the presence of powerful radio jets is of substantial importance for observing a significant γ-ray counterpart even if these jets are misaligned with respect to the line of sight. We also find that most of the X-ray-brightest LLAGN do not have a significant γ-ray and strong radio emission, suggesting that the X-rays come mainly from the accretion flow in these cases. A detailed analysis of the spectral energy distributions (SEDs) of NGC 315 and NGC 4261, both detected in γ-rays, is provided where we make a detailed comparison between the predicted hadronic γ-ray emission from a radiatively inefficient accretion flow (RIAF) and the γ-ray emission from a leptonic jet-dominated synchrotron self-Compton (SSC) model. Both SEDs are better described by the SSC model, while the RIAF fails to explain the γ-ray observations.
The Ophiuchus stream progenitor: a new type of globular cluster and its possible Sagittarius connection
Authors: Lane James M M , Navarro Julio F , Fattahi Azadeh , Oman Kyle A , Bovy Jo 
Published: January 2020

ABSTRACT
The Ophiuchus stream is a short arc-like stellar feature of uncertain origin located ∼5 kpc North of the Galactic centre. New proper motions from the second Gaia data release reconcile the direction of motion of stream members with the stream arc, resolving a puzzling mismatch reported in earlier work. We use N-body simulations to show that the stream is likely only on its second pericentric passage, and thus was formed recently. The simulations suggest that most of the disrupted progenitor is visible in the observed stream today, and that little further tidal debris is expected to lie beyond the ends of the stream. The luminosity, length, width, and velocity dispersion of the stream suggest a globular cluster (GC) progenitor substantially fainter and of lower surface brightness than estimated in previous work, and unlike any other known globulars in the Galaxy. This result suggests the existence of clusters that would extend the known GC population to fainter and more weakly bound systems than hitherto known. How such a weakly bound cluster of old stars survived until it was disrupted so recently, however, remains a mystery. Integrating backwards in time, we find that the orbits of Sagittarius and Ophiuchus passed within ∼5 kpc of each other about ∼100 Myr ago, an interaction that might help resolve this puzzle.
Trend filtering – I. A modern statistical tool for time-domain astronomy and astronomical spectroscopy
Authors: Politsch Collin A , Cisewski-Kehe Jessi , Croft Rupert A C , Wasserman Larry 
Published: January 2020

ABSTRACTThe problem of denoising a 1D signal possessing varying degrees of smoothness is ubiquitous in time-domain astronomy and astronomical spectroscopy. For example, in the time domain, an astronomical object may exhibit a smoothly varying intensity that is occasionally interrupted by abrupt dips or spikes. Likewise, in the spectroscopic setting, a noiseless spectrum typically contains intervals of relative smoothness mixed with localized higher frequency components such as emission peaks and absorption lines. In this work, we present trend filtering, a modern non-parametric statistical tool that yields significant improvements in this broad problem space of denoising spatially heterogeneous signals. When the underlying signal is spatially heterogeneous, trend filtering is superior to any statistical estimator that is a linear combination of the observed data – including kernel smoothers, LOESS, smoothing splines, Gaussian process regression, and many other popular methods. Furthermore, the trend filtering estimate can be computed with practical and scalable efficiency via a specialized convex optimization algorithm, e.g. handling sample sizes of n ≳ 107 within a few minutes. In a companion paper, we explicitly demonstrate the broad utility of trend filtering to observational astronomy by carrying out a diverse set of spectroscopic and time-domain analyses.
HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration
Authors: Tang Xiaolong , Li Guo , Su Fengting , Cai Yanlin , Shi Lei , Meng Yuan , Liu Zuojun , Sun Jie , Wang Ming , Qian Minxian , Wang Zimei , Xu Xingzhi , Cheng Yong-Xian , Zhu Wei-Guo , Liu Baohua 
Published: January 2020

AbstractNAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated is still largely unclear. TGF-β signaling is highly conserved in multicellular organisms, regulating cell growth, cancer stemness, migration and invasion. Here, we demonstrate that histone deacetylase HDAC8 forms complex with SMAD3/4 heterotrimer and occupies SIRT7 promoter, wherein it deacetylates H4 and thus suppresses SIRT7 transcription. Treatment with HDAC8 inhibitor compromises TGF-β signaling via SIRT7-SMAD4 axis and consequently, inhibits lung metastasis and improves chemotherapy efficacy in breast cancer. Our data establish a regulatory feedback loop of TGF-β signaling, wherein HDAC8 as a novel cofactor of SMAD3/4 complex, transcriptionally suppresses SIRT7 via local chromatin remodeling and thus further activates TGF-β signaling. Targeting HDAC8 exhibits therapeutic potential for TGF-β signaling related diseases.
ScaR—a tool for sensitive detection of known fusion transcripts: establishing prevalence of fusions in testicular germ cell tumors
Authors: Zhao Sen , Hoff Andreas M , Skotheim Rolf I 
Published: January 2020

Abstract
Bioinformatics tools for fusion transcript detection from RNA-sequencing data are in general developed for identification of novel fusions, which demands a high number of supporting reads and strict filters to avoid false discoveries. As our knowledge of bona fide fusion genes becomes more saturated, there is a need to establish their prevalence with high sensitivity. We present ScaR, a tool that uses a supervised scaffold realignment approach for sensitive fusion detection in RNA-seq data. ScaR detects a set of 130 synthetic fusion transcripts from simulated data at a higher sensitivity compared to established fusion finders. Applied to fusion transcripts potentially involved in testicular germ cell tumors (TGCTs), ScaR detects the fusions RCC1-ABHD12B and CLEC6A-CLEC4D in 9% and 28% of 150 TGCTs, respectively. The fusions were not detected in any of 198 normal testis tissues. Thus, we demonstrate high prevalence of RCC1-ABHD12B and CLEC6A-CLEC4D in TGCTs, and their cancer specific features. Further, we find that RCC1-ABHD12B and CLEC6A-CLEC4D are predominantly expressed in the seminoma and embryonal carcinoma histological subtypes of TGCTs, respectively. In conclusion, ScaR is useful for establishing the frequency of known and validated fusion transcripts in larger data sets and detecting clinically relevant fusion transcripts with high sensitivity.
Development of a person-centered interdisciplinary plan-of-care program for dialysis
Authors: Dorough Adeline , Forfang Derek , Murphy Shannon L , Mold James W , Kshirsagar Abhijit V , DeWalt Darren A , Flythe Jennifer E 
Published: January 2020

Abstract

Background
Dialysis care often focuses on outcomes that are of lesser importance to patients than to clinicians. There is growing international interest in individualizing care based on patient priorities, but evidence-based approaches are lacking. The objective of this study was to develop a person-centered dialysis care planning program. To achieve this objective we performed qualitative interviews, responsively developed a novel care planning program and then assessed program content and burden.

Methods
We conducted 25 concept elicitation interviews with US hemodialysis patients, care partners and care providers, using thematic analysis to analyze transcripts. Interview findings and interdisciplinary stakeholder panel input informed the development of a new care planning program, My Dialysis Plan. We then conducted 19 cognitive debriefing interviews with patients, care partners and care providers to assess the program’s content and face validities, comprehensibility and burden.

Results
We identified five themes in concept elicitation interviews: feeling boxed in by the system, navigating dual lives, acknowledging an evolving identity, respecting the individual as a whole person and increasing individualization to enhance care. We then developed a person-centered care planning program and supporting materials that underwent 32 stakeholder-informed iterations. Data from subsequent cognitive interviews led to program revisions intended to improve contextualization and understanding, decrease burden and facilitate implementation.

Conclusions
My Dialysis Plan is a content-valid, person-centered dialysis care planning program that aims to promote care individualization. Investigation of the program’s capacity to improve patient experiences and outcomes is needed.
T2/FLAIR-mismatch sign for noninvasive detection of IDH-mutant 1p/19q non-codeleted gliomas: validity and pathophysiology
Authors: Foltyn Martha , Nieto Taborda Karen Natalia , Neuberger Ulf , Brugnara Gianluca , Reinhardt Annekathrin , Stichel Damian , Heiland Sabine , Herold-Mende Christel , Unterberg Andreas , Debus Jürgen , Deimling Andreas von , Wick Wolfgang , Bendszus Martin , Kickingereder Philipp 
Published: January 2020

Abstract

Background
This study aimed to assess the validity and pathophysiology of the T2/FLAIR-mismatch sign for noninvasive identification of isocitrate dehydrogenase (IDH)-mutant 1p/19q non-codeleted glioma.

Methods
Magnetic resonance imaging scans from 408 consecutive patients with newly diagnosed glioma (113 lower-grade gliomas and 295 glioblastomas) were evaluated for the presence of T2/FLAIR-mismatch sign by 2 independent reviewers. Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess the performance of the T2/FLAIR-mismatch sign for identifying IDH-mutant 1p/19q non-codeleted tumors. An exploratory analysis of differences in contrast-enhancing tumor volumes, apparent diffusion coefficient (ADC) values, and relative cerebral blood volume (rCBV) values in IDH-mutant gliomas with versus without the presence of a T2/FLAIR-mismatch sign (as well as analysis of spatial differences within tumors with the presence of a T2/FLAIR-mismatch sign) was performed.

Results
The T2/FLAIR-mismatch sign was present in 12 cases with lower-grade glioma (10.6%), all of them being IDH-mutant 1p/19q non-codeleted tumors (sensitivity = 10.9%, specificity = 100%, PPV = 100%, NPV = 3.0%, accuracy = 13.3%). There was a substantial interrater agreement to identify the T2/FLAIR-mismatch sign (Cohen’s kappa = 0.75 [95% CI, 0.57–0.93]). The T2/FLAIR-mismatch sign was not identified in any other molecular subgroup, including IDH-mutant glioblastoma cases (n = 5). IDH-mutant gliomas with a T2/FLAIR-mismatch sign showed significantly higher ADC (P &lt; .0001) and lower rCBV values (P = .0123) as compared to IDH-mutant gliomas without a T2/FLAIR-mismatch sign. Moreover, in IDH-mutant gliomas with T2/FLAIR-mismatch sign the ADC values were significantly lower in the FLAIR-hyperintense rim as compared to the FLAIR-hypointense core of the tumor (P = .0005).

Conclusions
This study confirms the high specificity of the T2/FLAIR-mismatch sign for noninvasive identification of IDH-mutant 1p/19q non-codeleted gliomas; however, sensitivity is low and applicability is limited to lower-grade gliomas. Whether the higher ADC and lower rCBV values in IDH-mutant gliomas with a T2/FLAIR-mismatch sign (as compared to those without) translate into a measurable prognostic effect requires investigation in future studies. Moreover, spatial differences in ADC values between the core and rim of tumors with a T2/FLAIR-mismatch sign potentially reflect specific distinctions in tumor cellularity and microenvironment.