bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass‐transport complexes (MTCs) document subsidence patterns in a northern Gulf of Mexico salt minibasin
Authors: Wu Nan , Jackson Christopher A.‐L. , Johnson Howard D. , Hodgson David M. , Nugraha Harya D. 
Published: January 2020

AbstractMass‐transport complexes (MTCs) dominate the stratigraphic record of many salt‐influenced sedimentary basins. Commonly in such settings, halokinesis is invoked as a primary trigger for MTC emplacement, although the link between specific phases of salt movement, and related minibasin dynamics, remains unclear. Here, we use high‐quality 3D seismic reflection and well data to constrain the composition, geometry and distribution (in time and space) of six MTCs preserved in a salt‐confined, supra‐canopy minibasin in the northern Gulf of Mexico, and to assess how their emplacement relate to regional and local controls. We define three main tectono‐sedimentary phases in the development of the minibasin: (a) initial minibasin subsidence and passive diapirism, during which time deposition was dominated by relatively large‐volume MTCs (c. 25 km3) derived from the shelf‐edge or upper slope; (b) minibasin margin uplift and steepening, during which time small‐volume MTCs (c. 20 km3) derived from the shelf‐edge or upper slope were emplaced; and (c) active diapirism, during which time very small volume MTCs (c. 1 km3) were emplaced, locally derived from the diapir flanks or roofs. We present a generic model that emphasizes the dynamic nature of minibasin evolution, and how MTC emplacement relates to halokinetic sequence development. Although based on a single data‐rich case study, our model may be applicable to other MTC‐rich, salt‐influenced sedimentary basins.
The prognosis of non‐small cell lung cancer combined with chronic obstructive pulmonary disease: A systematic review and meta‐analysis
Authors: Wu Ke , Wang Jing , Zhao Limin , Wang Pei , Duan Qi 
Published: January 2020

AbstractObjectiveTo investigate the effect of non‐small cell lung cancer (NSCLC) combined with Chronic Obstructive Pulmonary Disease (COPD) on prognosis, so as to provide help to clinical diagnosis and treatment.MethodsPubMed, Web of Science and the Medline were used to retrieve studies reported from 1950 to 2019. If the study reported the prognosis of COPD with NSCLC, the study was included and the relevant information was extracted and the data analyzed. The standard mean deviation (SMD) of 95% confidence interval was used in this meta‐analysis.ResultsA total of 851 data studies were reviewed for eligibility, eventually, 12 case‐control studies were included in this systematic review and meta‐analysis. The sample sizes for company's studies of NSCLC ranged from 85 to 10 378, with a total number of 14 164, including 2450 COPD and 9395 Non‐COPD. Meta‐analyses showed that concomitant COPD was associated with poorer OS compared with patients without COPD (Fixed: HR: 1.16; 95% CI: 1.08‐1.25. Random: HR: 1.07; CI: 0.92‐1.24), with a significant heterogeneity across studies (I2 = 45%, P = 0.04).ConclusionOur study showed that patients with combined COPD had an impact on the prognosis and survival rate of SCLC patients.
Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register
Authors: Kong Alice P. S. , Lew Thomas , Lau Eric S. H. , Lim Lee‐Ling , Kesavadev Jothydev , Jia Weiping , Sheu Wayne H.‐H. , Sobrepena Leorino , Tan Alexander T. B. , Nguyen Thy Khue , Yoon Kun‐Ho , Wang Ke , Kodiappan Kamlanathan , Treuer Tamás , Chan Juliana C. N. ,   on behalf of the JADE Collaborative Study Group
Published: January 2020

AbstractAimsTo explore the pattern of insulin use and glycaemic control in Asian people with type 2 diabetes, stratified by gender, young‐onset diabetes (YOD; diagnosed before age 40 years), and diabetic kidney disease (DKD; estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73m2).Materials and methodsWe conducted a cross‐sectional analysis of 97 852 patients from 11 Asian countries/regions (2007–2017) included in the prospective Joint Asia Diabetes Evaluation (JADE) Register.ResultsAmong 18 998 insulin users (47% women, mean ± SD age 59.2 ± 11.7 years, diabetes duration 13.2 ± 8.3 years, glycated haemoglobin [HbA1c] 72 ± 21.4 mmol/mol [8.74 ± 1.95%], median total daily insulin dose [TDD] 0.27–0.82 units/kg), 25% and 29.5% had YOD and DKD, respectively. Premixed (44%) and basal‐only (42%) insulin were the most common regimens. Despite being more commonly treated with these two regimens with higher insulin dosages, patients with YOD had worse HbA1c levels than their late‐onset peers (73 ± 20.5 vs. 71 ± 21.2 mmol/mol [8.82 ± 1.87% vs. 8.66 ± 1.94%]; P < 0.001). Fewer women than men attained an HbA1c level < 53 mmol/mol (7%; 15.7% vs 17.1%; P = 0.018). Adjusting for age, diabetes duration, TDD, HbA1c, eGFR, and use of oral glucose‐lowering drugs at baseline, the odds of self‐reported hypoglycaemia were higher in women (vs. men: adjusted odds ratio [aOR] 1.16, 95% confidence interval [CI] 1.05–1.28) and in patients with DKD treated with a premixed regimen (1.81 [95% CI 1.54–2.13] vs. 1.34 [95% CI 1.16–1.54] in non‐DKD; Pinteraction < 0.001). Compared to basal‐only regimens, premixed and basal‐bolus regimens had similar HbA1c reductions but were independently associated with increased odds of hypoglycaemia (1.65 [95% CI 1.45–1.88] and 1.88 [95% CI 1.58–2.23], respectively).ConclusionsIn this Asian population, there were varying patterns of insulin regimens with suboptimal glycaemic control, despite relatively high TDDs, which were influenced by gender, DKD, and YOD status.
The FEBS Journal in 2020: Open Access and quality versus quantity publishing
Authors: Martin Seamus J. 
Published: January 2020

AbstractThe FEBS Journal, a leading multidisciplinary journal in the life sciences, continues to grow in visibility and impact. Here, Editor‐in‐Chief Seamus Martin discusses the potential impact of the ‘author pays’ publishing model on research quality, and some of the highlights at the journal over the past year.
Urban regeneration in urban functional areas in Poland as an instrument of implementation of the EU Cohesion Policy
Authors: Kamrowska‐Załuska Dorota , Obracht‐Prondzyńska Hanna 
Published: January 2020

AbstractThis study examines the role of urban regeneration policies in planning and governance within urban functional areas (UFAs) in Poland, in the context of the EU Cohesion Policy (CP). The empirical part of this study is based on comparing the approaches adopted in two Polish regions: Pomerania and Silesia. We describe the first successes but also the bottlenecks of the process, from negotiations and programming up to the implementation of the first tranche of integrated projects. We consider the factors that strengthen planning and governance within UFAs, while simultaneously influencing the local development, and territorial impacts of the EU Cohesion Policy in the given regions. This study is based on interviews with national, regional, and local actors. It defines the role of urban regeneration policies in shaping local socio‐economic and spatial development in these regions and identifies the conditions required for the implementation of urban regeneration in functional areas. We also draw lessons for the future CP programming period from the experience of Polish regions, among the main beneficiaries of the EU Cohesion Policy. By evaluating the influence of Cohesion Policy at different government levels, our study may influence the discourse on its future, particularly in the context of strengthening the cooperation and multilevel governance.
CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Authors: Pluchino Nicola , Mamillapalli Ramanaiah , Shaikh Shafiq , Habata Shutaro , Tal Aya , Gaye Marie , Taylor Hugh S. 
Published: January 2020

AbstractAdult stem cells have a major role in endometrial physiology, including remodelling and repair. However, they also have a critical role in the development and progression of endometriosis. Bone marrow‐derived stem cells engraft eutopic endometrium and endometriotic lesions, differentiating to both stromal and epithelial cell fates. Using a mouse bone marrow transplantation model, we show that bone marrow‐derived cells engrafting endometriosis express CXCR4 and CXCR7. Targeting either receptor by the administration of small molecule receptor antagonists AMD3100 or CCX771, respectively, reduced BM‐derived stem cell recruitment into endometriosis implants. Endometriosis lesion size was decreased compared to vehicle controls after treatment with each antagonist in both an early growth and established lesion treatment model. Endometriosis lesion size was not effected when the local effects of CXCL12 were abrogated using uterine‐specific CXCL12 null mice, suggesting an effect primarily on bone marrow cell migration rather than a direct endometrial effect. Antagonist treatment also decreased hallmarks of endometriosis physiopathology such as pro‐inflammatory cytokine production and vascularization. CXCR4 and CXCR7 antagonists are potential novel, non‐hormonal therapies for endometriosis.
Solvent fractions of fermented Trapa japonica fruit extract stimulate collagen synthesis through TGF‐β1/GSK‐3β/β‐catenin pathway in human dermal fibroblasts
Authors: Nam Gun‐He , Kawk Hye Won , Kim Sang‐Yong , Kim Young‐Min 
Published: January 2020

AbstractBackgroundThe dermis, composed predominantly of dermal fibroblasts and extracellular matrix (ECM), consists of fibrous proteins such as collagen and elastin and is associated with wrinkle formation and dermal elasticity. As the major constituent of the dermal matrix, collagen strengthens the skin, enhances its elasticity and protects it from external factors, such as ultraviolet (UV) rays, skin inflammation, intracellular metabolites, and aging.AimsEconomic growth and long‐life expectancy have increased the interest in beauty, with extensive studies conducted to evaluate the anti‐aging and health‐promoting benefits of bioactive substances.MethodsIn this study, we used natural ingredients, Trapa japonica fruit is a hard, aquatic plant that grows in ponds or marshes and contains protein and starch. To develop the ingredients for comprehensive skin improvement, this study investigated the effects of the trapa japonica fruit extract on the improvement of skin cells.ConclusionWe investigated the role of the fermented hot‐water trapa japonica fruit extract to isolate the active ingredients with antiwrinkle effects in vitro and ex vivo situation through human dermal fibroblast cell proliferation via activating TGF‐β1/GSK‐3β/β‐catenin pathway.
The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial
Authors: Kalman Douglas S. , Hewlings Susan 
Published: January 2020

AbstractBackgroundMany over the counter and consumer packaged goods are promoted to enhance the appearance of hair, skin, and nails for the consumer. Nutrition is a major factor in affecting the health and appearance of hair, skin, and nails. In addition to how one eats, dietary supplementation may play a role in overall health and in the physical appearance.AimsIt was the aim of this study to objectively and subjectively evaluate the impacts of a nutritional intervention as compared to placebo on the appearances of hair, skin, and nails in healthy middle‐aged adults.MethodsRandomized, double‐blind placebo‐controlled study with 88 subjects randomized evenly to Study Product (BiovaBio™ 450 mg/d, n = 44) or Placebo (n = 44) for 12‐weeks. Outcome tests included TrichoScan HD (hair), Canfield Visia®‐CR (skin), modified FACE‐Q (skin), and anchored Likert Scales (nails).ResultsOral hydrolyzed eggshell membrane ingestion was associated with a significant improvement in facial skin appearance in crow's feet in 4 weeks and skin tone in 8 weeks, with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth at 4, 8, and 12 weeks. There were no observed subjective improvements for nails (appearance, strength or growth).ConclusionsOral supplementation of 450 mg/d hydrolyzed eggshell membrane for 12 weeks is associated with improvement in the appearance of facial skin and hair.
Cohabitation and Marriage: Complexity and Diversity in Union‐Formation Patterns
Authors: Sassler Sharon , Lichter Daniel T. 
Published: January 2020

AbstractNonmarital cohabitation and marriage are now fundamentally linked, a fact that is routinely reflected in current research on union formation. Unprecedented changes in the timing, duration, and sequencing of intimate co‐residential relationships have made the study of traditional marriage far more complex today than in the past. It is now clear that a white, middle‐class, American‐centric research template has become increasingly anachronistic. In this review article, we begin by providing an overview of contemporary theory, empirical approaches, and demographic trends in cohabitation and marriage, focusing primarily on the United States, but also distinguishing the U.S. from patterns found in other high‐income societies, including European countries, Canada, Australia, and in East Asia. We place the spotlight on the causes and consequences of union transitions. We identify the commonalities between cohabitation and marriage, but also key differences that are expressed unevenly across different populations and cultural groups. The rise in nonmarital cohabitation has upended conventional theoretical models and measurement approaches to the study of traditional marriage, complicating matters but also reinvigorating family scholarship on union formation and its implications for partners, children, and society.
Ethnic–Racial Socialization in the Family: A Decade's Advance on Precursors and Outcomes
Authors: Umaña‐Taylor Adriana J. , Hill Nancy E. 
Published: January 2020

AbstractIn the current decade, the U.S. population reached historically high levels of ethnic–racial diversity and reelected the nation's first Black–White biracial President. Simultaneously, scholars also documented significant ethnic–racial inequities in education, increased xenophobia, and a racial climate that revealed deep‐seated ethnic–racial tensions. Given this backdrop and acknowledging the significant role that families play in youths' abilities to navigate their social contexts, the current review focused on the literature on families' ethnic–racial socialization efforts with youth from the 2010 decade. Our review of 259 empirical articles revealed that there has been an exponential increase in research on family ethnic–racial socialization in this decade. Furthermore, although it is clear that family ethnic–racial socialization is a robust predictor of youths' adjustment, the associations between socialization and adjustment must be considered with attention to specific socialization strategies, the confluence of strategies used, and the unique contexts within which families' lives are embedded.
The Evolution of Fathering Research in the 21st Century: Persistent Challenges, New Directions
Authors: Schoppe‐Sullivan Sarah J. , Fagan Jay 
Published: January 2020

AbstractSince the last decade review of the fathering literature in 2000, scholars across numerous disciplines such as demography, family studies, medicine, nursing, law, psychology, social work, and sociology have continued to produce a steady stream of work on fathering and father–child relationships. This literature is reviewed selectively with a focus on key developments, persistent challenges, and critical directions for future research. Significant developments include greater availability of large and nationally representative datasets to study fathers; expansion and evaluation of U.S. federal policy regarding fathers; thoughtful consideration of conceptualization and measurement of fathers' parenting; growth in research on coparenting, maternal gatekeeping, and fathering; increased attention to issues of diversity in fathering; and awareness of the effects of fathering on men's development. Persistent challenges and critical new directions in fathering research include full and routine inclusion of fathers in research on parenting, improved assessment and appropriate data analysis, adherence to evidence‐based portrayals of fathers' roles in children's development, generation and use of scientific evidence to guide policy‐making, and sustained attention to diversity and fatherhood. These should be priority areas of focus as fathering research proceeds into the next decades of the 21st century.
Divorce, Repartnering, and Stepfamilies: A Decade in Review
Authors: Raley R. Kelly , Sweeney Megan M. 
Published: January 2020

AbstractThis article reviews key developments in the past decade of research on divorce, repartnering, and stepfamilies. Divorce rates are declining overall, but they remain high and have risen among people older than age 50. Remarriage rates have declined, but the overall proportion of marriages that are remarriages is rising. Transitions in parents' relationships continue to be associated with reduced child well‐being, but shifting patterns of divorce and repartnering during the past decade have also reshaped the family lives of older adults. We review research on the predictors and consequences of these trends and consider what they reveal about the changing significance of marriage as an institution. Overall, recent research on divorce, repartnering, and stepfamilies points to the persistence of marriage as a stratified and stratifying institution and indicates that the demographic complexity of family life is here to stay.
Paediatric bladder dysfunction: A single centre experience of public hospital wait times
Authors: Ling Norman , Trajanovska Misel , Griffith Andrew , Phan Tracey , Gibb Susan , Goldfeld Sharon , King Sebastian K 
Published: January 2020

AimPaediatric bladder dysfunction, including daytime urinary incontinence and enuresis, is a common and distressing condition. Unfortunately, children with these symptoms are often on waitlists for several months. This treatment delay may significantly impact upon the child and family unit. This study aimed to quantify waiting times for children who had attended hospital outpatient clinics for symptoms of wetting.MethodsA retrospective review was undertaken for patients who had been referred to The Royal Children's Hospital, Melbourne outpatient clinics for symptoms of wetting (with/without bowel symptoms). Data regarding the referral and triage pathway, up to the time of the first clinic appointment, were collected. These data were compared to a previous audit conducted in the same setting.ResultsA total of 101 clinic attendances were included in this study. The overall waiting time, from receipt of referral to the patient's first clinic attendance, was a median of 181 days (n = 94 valid responses; range 7–695). Wait times for patients with isolated symptoms of wetting were similar to patients with mixed bowel and bladder dysfunction (187 and 171.5 days, respectively). Most patients were triaged to the continence clinic (n = 68), whilst smaller proportions of patients were seen in the encopresis (n = 14), urology (n = 13), general medicine (n = 2), gastroenterology (n = 1) and nurse‐led enuresis clinic (n = 3).ConclusionsThe waiting times for patients with wetting generally exceeded 5 months. Alternative pathways for triage need to be explored to manage demand and improve wait times.
When the Former CEO Stays on Board: The Role of the Predecessor’s Board Retention for Product Innovation in Family Firms
Authors: Querbach Stephanie , Bird Miriam , Kraft Priscilla S. , Kammerlander Nadine 
Published: January 2020

Understanding product innovation in family firms is an important research endeavor given the economic predominance of those firms, their idiosyncrasies, and the importance of constant renewal for those firms to achieve transgenerational survival. Recently, family firm research has highlighted the role of next‐generation chief executive officers (CEOs; i.e., successors) who are often seen as drivers for innovating a family firm’s products. However, prior research has typically neglected that predecessors, who are often portrayed as less willing to introduce product innovation, frequently remain involved postsuccession through occupying board positions and thus still substantially influence the decision‐making processes and outcomes of family firms, such as product innovation. As a result, our understanding of the role of predecessors and their postsuccession involvement in family firms’ product innovation remains unclear. Building on stakeholder salience theory and on insights from the literature on innovation and succession in family firms, we develop hypotheses about how and under which conditions the predecessor’s board retention affects product innovation in family firms after succession. Building on more than 200 family firm CEO succession cases in small‐ and medium‐sized, privately owned family firms, our results reveal that the predecessor’s board retention negatively affects product innovation. This negative effect is strengthened with increasing involvement of the predecessor in the successor selection process, and it is offset in the case of family succession. Our findings contribute to the emerging stream of research on family firm succession and product innovation and provide important implications for practice.
The Impact of Divergence Tilt and Meridional Flow for Cross-Equatorial Eddy Momentum Transport in Gill-Like Settings
Authors: Zurita-Gotor Pablo 
Published: January 2020

AbstractThis work investigates the sensitivity of the cross-equatorial eddy momentum flux and its rotational and divergent components to Hadley cell strength in simple variants of the Gill problem. An expression is derived linking the divergent momentum flux to the mean meridional wavenumber weighted by the spectrum of divergent eddy kinetic energy, supporting the relation between divergence phase tilt and momentum flux suggested by a previous study. Newtonian cooling makes the divergence tilt eastward moving away from the equator as observed, but this tilt is also sensitive to the Hadley cell. As the divergence tilt is enhanced in the downstream direction of the flow, wave propagation increases along that direction when the Hadley cell strengthens. The meridional flow also plays a second, important role for cross-equatorial propagation. With no Hadley cell, inviscid Sverdrup balance requires perfect compensation between the divergent and rotational momentum fluxes at the equator. The model can only produce cross-equatorial propagation when Sverdrup balance is violated, which in the linear, nearly inviscid limit requires vorticity advection by the mean flow. As the Hadley cell attenuates the geopotential tilt imparted by the divergent forcing, the compensation by the rotational momentum flux is reduced. The linear model can reproduce reasonably well previous nonlinear results by Kraucunas and Hartmann when linearized about their zonal-mean climatologies. The sensitivity of the cross-equatorial momentum fluxes to Hadley cell strength in these solutions is dominated by changes in the divergent flux and consistent with diagnosed changes in the divergence tilt.