bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of new-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction
Authors: Minder Judith , Mannhart Diego , Brunner Sarah , Di Bari Gianluca , Knecht Sven , Krisai Philipp , Nestelberger Thomas , Boeddinghaus Jasper , Leibundgut Gregor , Kaiser Christoph , Mueller Christian , Osswald Stefan , Sticherling Christian , Kühne Michael , Badertscher Patrick 
Published: December 2024

Abstract
Background
New-onset atrial fibrillation (NOAF) complicating ST-segment elevation myocardial infarction (STEMI) remains clinically challenging. The aim of this study was to assess the incidence of NOAF, identify risk factors for the development of atrial fibrillation (AF), and analyze the impact on patient care, therapy, and outcomes during long-term follow-up.

Methods
This retrospective single-center study reviewed consecutive patients undergoing coronary angiography (CAG) for acute STEMI between May 2015 and September 2023. Patients were stratified in NOAF, defined as AF diagnosed during the index hospitalization or within 12 months of follow-up, AF prior to the hospitalization for STEMI, and patients with no AF.

Results
We analyzed 1301 consecutive patients undergoing CAG for STEMI. NOAF was detected in 112 patients (9.8%), and 68 patients (5.2%) had prior AF. NOAF patients were 74% males, with a mean age of 69 ± 11 years. During a median follow-up of 683 days, the rates of stroke were 10% in patients with NOAF compared to 3.8% (p = 0.001) in patients without AF. Major bleeding occurred in 7% vs. 1.7%, p = 0.001, and death in 16% vs. 6.8%, p < 0.001 of patients with NOAF vs. no AF.

Conclusion
NOAF was detected in almost 1 out of 10 STEMI patients and was associated with a higher rate of stroke, major bleeding, and death as in patients with no AF and with similar rates compared with prior AF. Future studies assessing optimal anticoagulation therapy in this challenging patient population are warranted.

Graphical abstract
Central illustration: New-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction: Inclusion criteria, stratification, and outcome data of AF and no AF patients in ST-segment elevation myocardial infarction. AF atrial fibrillation, NOAF new-onset atrial fibrillation
Alpha-helices as alignment reporters in residual dipolar coupling analysis of proteins
Authors: Shen Yang , Smith Marshall J. , Louis John M. , Bax Ad 
Published: December 2024

Abstract
Inclusion of residual dipolar couplings (RDCs) during the early rounds of protein structure determination requires use of a floating alignment tensor or knowledge of the alignment tensor strength and rhombicity. For proteins with interdomain motion, such analysis can falsely hide the presence of domain dynamics. We demonstrate for three proteins, maltotriose-ligated maltose binding protein (MBP), Ca2+-ligated calmodulin, and a monomeric N-terminal deletion mutant of the SARS-CoV-2 Main Protease, MPro, that good alignment tensor estimates of their domains can be obtained from RDCs measured for residues that are identified as α-helical based on their chemical shifts. The program, Helix-Fit, fits the RDCs to idealized α-helical coordinates, often yielding a comparable or better alignment tensor estimate than fitting to the actual high-resolution X-ray helix coordinates. The 13 helices of ligated MBP all show very similar alignment tensors, indicative of a high degree of order relative to one another. By contrast, while for monomeric MPro the alignment strengths of the five helices in the C-terminal helical domain (residues 200–306) are very similar, pointing to a well-ordered domain, the single α-helix Y54-I59 in the N-terminal catalytic domain (residues 10–185) aligns considerably weaker. This result indicates the presence of large amplitude motions of either Y54-I59 or of the entire N-terminal domain relative to the C-terminal domain, contrasting with the high degree of order seen in the native homodimeric structure.
Starving and deceiving: Are politicians with childhood famine exposure more honest?
Authors: Chen Shuo , Fan Xinyu , Wang Xuanyi 
Published: December 2024

AbstractDishonest politicians can jeopardize economic development. How do disasters change politicians’ incentives to lie? We employ a difference-in-differences approach to show that public officials who were exposed to China’s 1959–1961 famine as children (aged 0–6 years) are less likely to manipulate local GDP calculations; the reduction is more significant for officials who were more severely impacted by the disaster. We further reveal that famine-exposed local politicians take stronger moral stances on honesty, and are thus more reluctant to lie. The paper highlights how fraudulent policymaking in the past alters society’s long-term welfare through changing future government officials’ behaviors.
The influence of mode of remote delivery on health-related quality of life outcome measures in British Sign Language: a mixed methods pilot randomised crossover trial
Authors: Rogers Katherine D. , Marsden Antonia , Young Alys , Evans Chris 
Published: December 2024

Abstract
Objectives
Little is known about the efficacy of remotely delivered outcome measures (psychological/health-related assessments) in a signed language for Deaf people. The objective is to explore the equivalence of two modes of remote delivery of health-related quality of life outcome measures in British Sign Language (BSL): asynchronous online assessment versus synchronous live face-to-face online assessment in sign language.

Methods
Thirty-one participants were recruited through Deaf networks and sign language media. Measures used were validated BSL versions of the EQ-5D-5L, EQ-VAS and CORE-10. A randomised, crossover trial was conducted between March and May 2023 with seventeen first receiving asynchronous assessment and sixteen first receiving synchronous live online assessment. This study explored whether the outcomes of the two assessments are equivalent regardless of modality of delivery. Demographic data were collected, and eight participants took part in semi-structured qualitative interviews exploring modality preferences and the impact of each modality.

Results
The mean difference between pre-recorded and live modes was 0.034 for EQ-5D-5L BSL (90% CI 0.015–0.051), 4.33 mean difference for EQ-VAS BSL (90% CI 0.697–8.083), and mean difference of 0.17 for CORE-10 BSL (90% CI − 1.4065 to 1.1775). The confidence intervals for each of the EQ-5D-5L BSL, EQ-VAS BSL, and CORE-10 BSL lie within the prespecified equivalence margins which suggested that the two modes are equivalent.

Conclusion
The results demonstrate that EQ-5D-5L BSL, EQ-VAS BSL, and CORE-10 BSL may be considered as equivalent across modes of remote delivery. This further strengthens the validation of existing standardised assessments in BSL.
A BSL version of the abstract is available in Supplementary Video 1.
Stroke and Sexual Health: A Systematic Review of Psychological Interventions Aimed at Improving Sexual Health of Stroke Survivors
Authors: Brandão Rita , Vasconcelos Priscila , Pereira Raquel , Quinta-Gomes Ana Luísa 
Published: December 2024

AbstractTo systematically review the existing literature on the efficacy of psychological interventions aimed at improving the sexual health of stroke survivors. A database search was conducted at MEDLINE (PubMed), Web of Science, EBSCO (APA PsycINFO and APA PsycArticles), and The Cochrane Library. PRISMA guidelines for systematic reviews were followed. Manuscripts were screened according to inclusion and exclusion criteria. The risk of bias was assessed using the ROBINS-I, Cochrane Collaboration’s Risk of Bias Tool, and the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies (JBI-CACS). From an initial 1053 publications identified, five studies were included in the present study. The study designs of the selected studies included randomized controlled trials, quasi-experimental studies, a cross-sectional study, and a case study. The predominant intervention model used in most studies was the PLISSIT model. No studies using a digital-delivered format were identified. This research underscores the potential benefits of tailored interventions for promoting sexual health in stroke survivors and highlights areas for future research.
ICT Use, Self-efficacy, and the Future of Eighth-Grade Students: a Qualitative Study of Gender Differences
Authors: Caeli Elisa Nadire , Caviglia Francesco , Bundsgaard Jeppe 
Published: December 2024

Abstract
In this study, we have examined gender differences in the way students relate to information and communication technologies (ICT), to learn more about their perceptions of gender-based stereotypes in this area. This study is based on the results of the 2018 International Computer and Information Literacy Study (ICILS), specifically regarding gender differences in responses identified in the Danish results (Bundsgaard et al., 2019). Whereas the results of the ICILS make visible important gender-related concerns, it does not examine the reasons that students complete the tasks and answer the questions as they do. This study seeks to address this. In 2022, we interviewed 44 Danish eighth-grade students in groups, and introduced them to the results of the ICILS 2018, which showed gender differences related to ICT use, studying and working with ICT in the future, and ICT self-efficacy. They were asked to discuss whether the results surprised them, what they thought caused the differences, and whether/how they thought these differences should be eliminated. This study reveals that stereotypes exist in the minds of the students, and that stereotypes contribute to the differences. However, many of the students do not regard gender differences in ICT as a problem. Based on our analysis, we argue that students need a broader conception of what ICT is, and how computers are used in society, which means that aspects of computer science need to be introduced in primary and secondary education.
The CT collateral map: collateral perfusion estimation and baseline lesion assessment after acute anterior circulation ischemic stroke
Authors: Ki Hee Jong , Roh Hong Gee , Kwak Jin Tae , Kim In Seong , Park Jeong Jin , Jeon Yoo Sung , Yang Hyun , Jung Sumin , Lee Ji Sung , Kim Hyun Jeong 
Published: December 2024

Abstract

Purpose
To investigate the clinical feasibility of a CT collateral map compared with an MRA collateral map, focusing on collateral perfusion (CP) estimation and baseline lesion assessment in acute ischemic stroke (AIS).

Materials and Methods
This retrospective analysis used selected data from a prospectively collected database. We generated CT collateral maps derived from CT perfusion, encompassing images of arterial, capillary, early venous (CMEV), late venous, and delay phases. Three raters assessed CP scores from MRA and CT collateral maps and CMEV lesion volumes. Lesion volumes of baseline diffusion-weighted imaging (bDWI) and cerebral blood flow rate (CBF) < 30% were automatically measured by the software. The agreement between MRA and CT collateral maps in CP estimation and the correlation between lesion volumes with a CBF < 30% and the CMEV for bDWI lesion volumes were analyzed.

Results
One-hundred ten patients (mean age ± standard deviation, 71 ± 14; 60 women) with AIS due to steno-occlusion of the internal carotid and/or middle cerebral arteries were included. The agreement between the MRA and CT collateral maps in CP grading was excellent (weighted κ = 0.93; 95% CI, 0.90–0.97). The concordance correlation coefficients (CCCs) of the CBF < 30% and CMEV for bDWI lesion volumes were 0.76 (95% CI, 0.60–0.91) and 0.97 (0.95–0.98), respectively.

Conclusion
The clinical feasibility of the CT collateral map is demonstrated by its significant correlation with the MRA collateral map in CP estimation and baseline lesion assessment.
Wie geht es Lehramtsstudierenden? Depressionssymptomatik angehender Lehrkräfte und deren Korrelate
Authors: Weyers Jonas , Pförtner Timo-Kolja , Krull Johanna , Hennemann Thomas , Hanisch Charlotte , König Johannes , Weber Rainer 
Published: December 2024

Zusammenfassung
Hintergrund
Während zur Verbreitung depressiver Symptome bei Hochschulstudierenden zahlreiche Studien vorliegen, steht diese Thematik speziell bei Lehramtsstudierenden nur selten im Zentrum. Angesichts der psychosozialen Belastungen im angestrebten Berufsbild können Studien in diesem Bereich wichtige Impulse für die Gestaltung von Präventionsmaßnahmen liefern. Die vorliegende Studie fokussiert auf (1) die Verbreitung depressiver Symptome bei Lehramtsstudierenden und (2) Korrelate im Bereich von Soziodemographie, Persönlichkeit und Studium.

Methode
Eine Stichprobe von 572 Lehramtsstudierenden der Universität zu Köln wurde über eine Online-Befragung erreicht. Die Abfrage depressiver Symptome erfolgte durch den Gesundheitsfragebogen für Patienten (PHQ-D). Zusätzlich wurden soziodemographische Merkmale, die Big Five sowie Merkmale und Erleben des Studiums erfragt. Die Analyse erfolgte über multiple ordinale logistische Regressionsmodelle zur Vorhersage der Depressionssymptomatik (keine Symptome, leichtgradige Symptome und mittelgradige/schwere Symptome).

Ergebnisse
Etwa ein Drittel der Stichprobe wies mindestens leichtgradige depressive Symptome auf. Eine signifikant höhere Depressionssymptomatik war mit höheren Neurotizismuswerten, einem höheren Belastungserleben im Studium und einer verstärkten berufswahlbezogenen Unsicherheit assoziiert. Darüber hinaus variierte die Depressionssymptomatik signifikant nach Lehramtsform (höhere Werte bei angehenden Lehrkräften der Sekundarstufe I bzw. I und II sowie Sonderpädagogik) und nach Studienabschnitt (höhere Werte bei Bachelor- im Vergleich zu Masterstudierenden).

Schlussfolgerung
Sowohl Eingangsvoraussetzungen (z. B. Neurotizismus) als auch studienbezogene Merkmale (bzw. potenzielle Stressoren) standen signifikant mit depressiven Symptomen in Zusammenhang. Angesicht der psychosozialen Belastungen im Lehrkräfteberuf könnte der Risikofaktor Neurotizismus ein Ansatzpunkt für Präventionsarbeit sein. Eine Integration berufsvorbereitender Angebote, beispielsweise Trainings zur Emotionsregulation, erscheint insbesondere in der Masterphase möglich.
A Moving Target: Firearm Deaths, Mental Health, and the Role of Physicians
Authors: Soliman Layla , Baines-Waiz Omari , Rozel John S. , Blankenship Kelly , Rachal James 
Published: December 2024

Abstract
Purpose of Review
This review aims to provide an updated overview of trends in firearm- related deaths, the mental health impact on communities, and clinical and legislative interventions. We examine existing interventions and highlight lesser-known yet impactful strategies, such as incorporating appropriate training in medical education on firearm safety. Additionally, we explore the broader impacts of firearm violence on community mental health and address the disputed topic of whether mental illness is a driving factor behind mass shootings.

Recent Findings
The rate of firearm suicides has continued to grow in the United States, even as firearm homicides have slightly declined. While the media often attributes mass shootings to the perpetrator having a mental illness, research indicates such symptoms only account for a small subset of shooters. Recent studies highlight the benefits of incorporating firearm safety into professional medical education, which can reduce barriers for healthcare providers when discussing safe storage practices with patients.

Summary
While suicide risk is frequently assessed among individuals with mental illnesses due to their heightened risk, other factors should be considered by all clinicians, not just those in mental health. Similarly, certain mental health symptoms may play a role in a small fraction of gun violence, but other risk factors account for most violence risk. Despite the implementation of firearm restriction laws and increased access to mental health resources, gaps remain that must be addressed to reduce not only the rate of suicide by firearm, but also the mental burden the aftermath has on the community.
Investigation of authors’ self-citation in contemporary forensic odontology literature
Authors: Angelakopoulos N. , Polukhin N. , Balla S.B. 
Published: December 2024

AbstractThis bibliometric investigation aimed to analyze trends in author self-citation within prominent forensic odontology literature and explore potential correlations between self-citation rates and publication attributes. We reviewed seven leading forensic sciences journals from 2003 to 2023. For this analysis, we focused on two specific timeframes: 2003–2007 and 2018–2023. Our review encompassed original research articles, reviews, and case reports. Eligible articles underwent detailed examination for article and author attributes and citation metrics. Utilizing univariable and multivariable negative binomial regression analyses, we explored potential associations between the number of self-citations and various publication characteristics. This study analyzed 415 articles related to forensic odontology, of which 237 (57.1%) included at least one self-citation. Key findings highlight prevalent topics such as dental age estimation and human dental identification. A significant portion of the studies involved prospective, retrospective, and cross-sectional designs, and there has been a notable increase in the number of reviews and meta-analyses in recent years compared to an equivalent past period. Self-citation was observed in over half of the analyzed articles, with a median total citation count of 31 and a median self-citation rate of 7.5%. Further bibliometric investigation is required to establish definitive conclusions regarding author self-citation patterns in forensic odontology literature, particularly by exploring longer time spans.
Instruments and Measurement Scales for Cognitive Frailty in Midlife: A Systematic Literature Review from 2013 to 2023
Authors: Meza Karina Sofia Lastre , Allegri Ricardo , Barceló Ernesto 
Published: December 2024

AbstractThis study is a systematic review addressing cognitive frailty, measurement instruments, and their impact on comprehensive care for older adults between 2013 and 2023. It seeks to identify findings on the distribution of studies in relation to year, country of publication, and methodology employed, as well as the instruments available to measure cognitive frailty and the scientific evidence supporting its assessment in midlife. We included studies published between 2013 and 2023 that addressed the topic of cognitive frailty and measurement instruments in midlife, excluding papers that did not provide primary data. A systematic search was performed in Scopus, PubMed, Web of Science, and Science Direct databases. The risk of bias was assessed using the Cochrane tool. Twenty-one studies were identified, of which three presented new instruments for measuring cognitive frailty, eleven focused on the validation and comparison of psychometric properties, and seven examined the assessment of frailty in midlife. Research on instruments for measuring cognitive frailty has grown in the last five years, concentrating on high- and upper-middle-income countries, with a quantitative and cross-sectional methodological approach. Validation and cross-cultural adaptation of scales such as FRAIL and the Tilburg Frailty Indicator predominate, demonstrating efficacy and validity in community settings. Only three studies validate Frailty Indices using longitudinal data in middle-aged population. The review highlights the efficacy and validity of existing instruments, as well as the growth in cognitive frailty research. Strengths include growing research and instrument validation; however, it is limited to high- and upper-middle-income countries. The review suggests increased attention to cognitive frailty, with new instruments incorporating cognitive components, which could improve assessment in midlife.
The Association Study of Targeted DNA Methylation and Thrombophilia
Authors: Kui Xiang , Feng Junfei , Leng Jing , Sun Cong , Tang Qiuheng , Li Haifeng 
Published: December 2024

Abstract
Objective
The aim of this study is to investigate the relationship of leukocytes DNA methylation in targeted sites and thrombophilia.

Methods
Eight thrombophilia patients and their kin-related individuals as the healthy control. Targeted DNA methylation from peripheral leukocytes were examined with MassArray. Multivariate correlation analysis was used to estimate targeted gene methylation as an independent risk factor of thrombophilia. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of thrombophilia.

Results
The age of thrombophilia group was higher than control group (P < 0.001). F5.24.CpG.10 and Protein S.44.CpG.29–33 methylation were significantly associated with thrombophilia negatively and positively (r = -0.7289, P < 0.01 and r = 0.5667, P < 0.05). F5.24.CpG.10 methylation was higher in control group (P < 0.01), but Protein S.44.CpG.29–33 methylation increased in thrombophilia group (P < 0.05). The areas under curve of ROC were 0.9297 and 0.8437, respectively.

Conclusion
Target DNA methylation in Protein S.44.CpG.29–33 island is associated with an elevated risk of thrombophilia.
Der Zusammenhang von körperlicher Aktivität, sportmotorischer Leistung und Bewegungsmotivation im späten Kindesalter – eine Querschnittstudie
Authors: Schoser Daria Sophia , Mackenbrock Juliane , Lendt Claas , Froböse Ingo , Wilke Christiane 
Published: December 2024

Zusammenfassung
Einleitung
Die aktuelle Forschung zeigt, dass sich Kinder und Jugendliche insgesamt zu wenig bewegen. Ihre körperliche Aktivität nimmt ab, je älter sie werden. Um diese Situation zu ändern, ist es notwendig, ein Verständnis der Faktoren zu erlangen, die ihr Bewegungsverhalten beeinflussen. Dazu wird die Bewegungsmotivation auf Grundlage der Selbstbestimmungstheorie in Zusammenhang mit der sportmotorischen Leistung und der körperlichen Aktivität untersucht.

Methode
Die Querschnittsstudie integrierte 230 Fünftklässler*innen im Alter von 9 bis 11 Jahren aus fünf weiterführenden Schulen einer Großstadt in Nordrhein-Westfalen. Mittels Fragebogen wurden Daten zur „Bedürfnisbefriedigung und Motivation zur Bewegung“, zur „körperlichen Aktivität“ sowie zur „Sportvereinspartizipation“ erhoben. Ergänzend wurde die sportmotorische Leistung mit dem „CHECK!“ getestet. Bivariate Korrelationsanalysen prüften die Zusammenhänge zwischen den Faktoren „Motivation“ und „Aktivität“ sowie „sportmotorische Leistung“. Im Anschluss erfolgte eine multiple lineare Regressionsanalyse, um Auswirkungen der Bewegungsmotivation auf die körperliche Aktivität sowie auf die sportmotorische Leistungsfähigkeit zu eruieren.

Ergebnisse
Die gefundenen Zusammenhänge zwischen selbstbestimmter Motivation, sportmotorischer Leistung und körperlicher Aktivität unterstützen die Annahme, dass Motivation eine wichtige Rolle für die sportmotorische Leistung und die Aktivität von Kindern spielt. Darüber hinaus zeigt sich eine mittlere Korrelation zwischen dem Grundbedürfnis nach Kompetenz und dem Faktor „sportmotorische Leistung“ (r = 0,221; p = 0,045) sowie zwischen der sozialen Eingebundenheit und der „körperlichen Aktivität“ (r = 0,305; p = 0,045).

Diskussion
Aus den Ergebnissen der Regressionsanalyse wird deutlich, dass vor allem die selbstbestimmte Motivation wichtige Hinweise sowohl auf den Grad der körperlichen Aktivität als auch auf die sportmotorische Leistung gibt. Diese Ergebnisse liefern wichtige Erkenntnisse, um potenzielle Interventionen zur Steigerung der motorischen Kompetenz und zur Bewegungsförderung zu entwickeln.