bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taking risks to improve safety? Workplace learning in anesthesia
Authors: Cuvelier Lucie 
Published: October 2019

PurposePrevious results show that the anesthetists’ activity during the planning phase is aimed at neither identifying risks nor pinpointing the adverse events likely to occur; rather, it is to devise “manageable situations” that are adapted to their own competences. The present paper focuses on the issue of understanding how, in practice, these “manageable situations” are constructed. In particular it wonders if a link between the seniority of anesthetists and the way they design these “manageable situations” may be established.Design/methodology/approachThe paper sought to answer these questions through a qualitative study conducted in partnership with anesthetists. The method, combining interviews and case-based simulation, required that 20 anesthetists “thought aloud”.FindingsResults show that the anesthetists sometimes selected a solution that they themselves and experts viewed as riskier. Why? And who selects a riskier solution? The answer is about workplace learning and the continuous development of experience-based competences. “Manageable situations” appear to be planned situations so as to propose solutions adapted not only to present competences but also for future competences to be developed. In that sense, they are part of a developmental process at work.Originality/valueThese findings have implications for practice and they open pathways for further research studies. They call for rethinking the link between experience and workplace learning.
Stock market data modelling using fitness-oriented JAYA algorithm-based deep belief network
Authors: Swamy A. Kullaya , B. Sarojamma 
Published: October 2019

Purpose
Data mining plays a major role in forecasting the open price details of the stock market. However, it fails to address the dimensionality and expectancy of a naive investor. Hence, this paper aims to study a future prediction model named time series model is implemented.

Design/methodology/approach
In this model, the stock market data are fed to the proposed deep neural networks (DBN), and the number of hidden neurons is optimized by the modified JAYA Algorithm (JA), based on the fitness function. Hence, the algorithm is termed as fitness-oriented JA (FJA), and the proposed model is termed as FJA-DBN. The primary objective of this open price forecasting model is the minimization of the error function between the modeled and actual output.

Findings
The performance analysis demonstrates that the deviation of FJA–DBN in predicting the open price details of the Tata Motors, Reliance Power and Infosys data shows better performance in terms of mean error percentage, symmetric mean absolute percentage error, mean absolute scaled error, mean absolute error, root mean square error, L1-norm, L2-Norm and Infinity-Norm (least infinity error).

Research limitations/implications
The proposed model can be used to forecast the open price details.

Practical implications
The investors are constantly reviewing past pricing history and using it to influence their future investment decisions. There are some basic assumptions used in this analysis, first being that everything significant about a company is already priced into the stock, other being that the price moves in trends

Originality/value
This paper presents a technique for time series modeling using JA. This is the first work that uses FJA-based optimization for stock market open price prediction.
Environmental pollution, economic growth and institutional quality: exploring the nexus in Nigeria
Authors: Egbetokun Samuel , Osabuohien Evans , Akinbobola Temidayo , Onanuga Olaronke Toyin , Gershon Obindah , Okafor Victoria 
Published: October 2019

PurposeInteraction between environmental pollution and economic growth determines the achievement of the green growth objective of developing economies. An economy turns around the inverted U-shaped environmental Kuznets curve (EKC) when pollution is effectively dampened by social, political and economic factors as such economy grows. Thus, the purpose of this paper is to examine the EKC considering the impact of institutional quality on six variables of environmental pollution (carbon dioxide (CO2), nitrous oxide (N2O), suspended particulate matters (SPM), rainfall, temperature and total greenhouse emission (TGH)) using the case of Nigeria.Design/methodology/approachThe EKC model includes population density, education expenditure, foreign direct investment and gross domestic investment as control variables, and it was analysed using the autoregressive distribution lag (ARDL) econometric technique, which has not been applied in the literature on Nigeria.FindingsThe results, inter alia, indicate that there is EKC for CO2and SPM. This implies that the green growth objective can be pursued in Nigeria with concerted efforts. Other environmental pollution indicators did not exert significant influence on economic growth.Practical implicationsTherefore, it is recommended that Nigeria’s institutional quality be strengthened to limit environmental pollution in light of economic growth.Originality/valuePrevious studies are yet to apply a more developed econometric method, like the ARDL, to estimate the EKC model for Nigeria. This study fills this observed knowledge gap.
Amelioration of colitis in mice by Leuconostoc lactis EJ‐1 by M1 to M2 macrophage polarization
Authors: Jang Se‐Eun , Min Sung‐Won 
Published: October 2019

AbstractDysregulation of immune responses to environmental antigens by the intestine leads to the chronic inflammatory disease, inflammatory bowel disease (IBD). Recent studies have thus sought to identify a dietary component that can inhibit lipopolysaccharide (LPS)‐induced nuclear factor‐kappa beta (NF‐κB) signaling to ameliorate IBD. This study assessed if the lactic acid bacteria (LAB) from kimchi, suppresses the expression of tumor necrosis factor‐alpha (TNF‐α) in peritoneal macrophages induced by LPS. Leuconostoc lactis EJ‐1, an isolate from LAB, reduced the expression of interleukin‐6 (IL‐6) and IL‐1β in peritoneal macrophages induced by LPS. The study further tested whether EJ‐1 alleviates colitis induced by 2,4,6‐trinitrobenzene sulfonic acid (TNBS) in mice. TNBS significantly increased myeloperoxidase (MPO) expression, macroscopic colitis scores, and colon shortening. Oral administration of L. lactis EJ‐1 resulted in an inhibited in TNBS‐induced loss in body weight, colon shortening, MPO activity, and NF‐κB and inducible nitric oxide synthase expression; it also led to a marked reduction in cyclooxygenase‐2 expression. L. lactis EJ‐1 also inhibited the TNBS‐induced expression of TNF‐α, IL‐1β, and IL‐6; however, it induced the expression of IL‐10. The M2 macrophage markers arginase I, IL‐10, and CD206 were elevated by EJ‐1. Collectively, these results suggest that EJ‐1 inhibits the NF‐κB signaling and polarizes M1‐ to M2‐macrophage transition, which help in ameliorating colitis.
The European lavender vote: Sexuality, ideology and vote choice in Western Europe
Authors: TURNBULL‐DUGARTE STUART J. 
Published: October 2019

AbstractIn many European democracies, political punditry has highlighted the attempts of political parties on the left to court the ‘lavender vote’ of lesbian, gay and bisexual individuals. This article examines the presence of a gay vote in Western Europe with a focus on assessing the role of sexuality in shaping individuals’ political preferences and voting behaviour. Empirically, the effect of sexuality on both ideological identification as well as party vote choice is analysed. Using a cumulative dataset of eight rounds of the European Social Survey between 2002 and 2017, this article demonstrates that partnered lesbians and gay men are more likely than comparable heterosexuals to identify with the left, support leftist policy objectives and vote for left‐of‐centre political parties. The analysis represents the first empirical cross‐national European study of the voting behaviour of homosexual individuals and sheds new light on the importance of sexuality as a predictor of political ideology and voting behaviour within the Western European context.
Plant‐based Milks: A Review of the Science Underpinning Their Design, Fabrication, and Performance
Authors: McClements David Julian , Newman Emily , McClements Isobelle Farrell 
Published: October 2019

AbstractMany consumers are interested in decreasing their consumption of animal products, such as bovine milk, because of health, environmental, and ethical reasons. The food industry is therefore developing a range of plant‐based milk alternatives. These milk substitutes should be affordable, convenient, desirable, nutritional, and sustainable. This article reviews our current understanding of the development of plant‐based milks. Initially, an overview of the composition, structure, properties, and nutritional profile of conventional bovine milk is given, because the development of successful alternatives depends on understanding the characteristics of real milk. The two main production routes for fabricating plant‐based milks are then highlighted: (i) disruption of plant materials (such as nuts, seeds, or legumes) to form aqueous suspensions of oil bodies; (ii) formation of oil‐in‐water emulsions by homogenization of oil, water, and emulsifiers. The roles of the different functional ingredients in plant‐based milks are highlighted, including oils, emulsifiers, thickeners, antioxidants, minerals, and other additives. The physicochemical basis of the appearance, texture, and stability of plant‐based milks is covered. The importance of the sensory attributes and gastrointestinal fate of bovine milk and plant‐based alternatives is also highlighted. Finally, potential areas for future work are discussed.
Hemodialysis as a Risk Factor for Ceftriaxone‐Associated Pseudolithiasis in Adults
Authors: Ubukata Masamitsu , Ohsawa Isao , Suzuki Hiroki , Asao Rin , Nakamura Yuya , Nishida Hirofumi , Nakamura Masayuki , Nitta Kosaku , Goto Yoshikazu , Gotoh Hiromichi 
Published: October 2019

AbstractCeftriaxone‐associated biliary pseudolithiasis is common among children; however, there are only a few reports of pseudolithiasis in adult patients on HD. This retrospective cohort study included 278 adult patients on ceftriaxone therapy from 1 February 2016 to 1 September 2018. Pseudolithiasis was defined as a new development of sludge or stones in the gallbladder within 60 days of ceftriaxone therapy. After excluding patients with preexisting gallstones and a history of cholecystectomy, 113 patients on maintenance HD, and another 98 patients were enrolled as the HD and control group, respectively. Thirteen patients developed pseudolithiasis. Its incidence was significantly higher in the HD group than that in the control group. Multivariate logistic regression analyses showed that development of pseudolithiasis was significantly associated with HD and ceftriaxone dose. Therefore, HD in patients receiving ceftriaxone therapy appears to be associated with a risk of pseudolithiasis. These findings highlight the need for careful follow‐up.
Production of Pork Sausages Using Pleaurotus eryngii with Different Treatments as Replacements for Pork Back Fat
Authors: Wang Liyan , Li Cheng , Ren Lili , Guo Hongyue , Li Yu 
Published: October 2019

AbstractThe effects of four treatments of Pleurotus eryngii (king oyster mushroom) as replacements for pork back fat were evaluated for the physicochemical, technological, and sensory properties; nitrite content; and amino acid profile in pork sausages. Five batches were manufactured: one control (formulated with pork back fat) and four treatments with raw, boiled, deep‐fried, and fried P. eryngii to replace the pork back fat in sausages. The results indicated that the fat content and energy value decreased, while the protein, moisture, total dietary fiber content, cooking loss, and water‐holding capacity of the modified sausages increased. All samples were judged acceptable for their sensory characteristics, with the best one being the sausage containing deep‐fried P. eryngii. The raw and fried P. eryngii decreased the residual nitrite content in the sausages. Boiled P. eryngii enhanced the essential amino acids content in the sausages, while the other P. eryngii treatments improved the nonessential amino acid content. In summary, P. eryngii may potentially replace fat in sausages.Practical ApplicationIn manufacturing pork sausages, the mushroom P. eryngii can substitute pork back fat to improve the nutritional quality by reducing fat and energy value, while enhancing the protein and total dietary fiber content in the sausages. Raw and fried P. eryngii decreased the residual nitrite content in the sausages. This study provides a basis for preparing healthier alternatives to traditional sausages by substituting pork fat with mushrooms.
Colonic mucosa‐associated candida assessed by biopsy culture is associated with disease severity in ulcerative colitis: A prospective study
Authors: Shah Jimil , Dutta Usha , Rudramurthy Shivaprakash , Chakrabarti Arunaloke , Sinha Saroj K. , Sharma Vishal , Mandavdhare Harshal , Sharma Pankaj , Kalsi Dimple , Popli Priyanka , Radhika Srinivasan , Das Ashim , Kochhar Rakesh 
Published: October 2019

ObjectiveTo evaluate the relationship of mucosa‐associated candida (MAC) and disease severity in patients with ulcerative colitis (UC).MethodsWe prospectively investigated the presence, nature, and quantification of MAC in patients with UC and its relationship with disease severity. Consecutive patients with UC were assessed for clinical, endoscopic, histological features and serum markers of disease severity. All patients underwent mucosal brushing cytology, brushing culture, and biopsy culture for candida growth. MAC was considered present if mucosal biopsy culture grew candida. Candida spp. identification was performed by matrix‐assisted laser desorption/ionization. Serum β‐D‐glucan was measured with a Fungitell assay. Patients with irritable bowel syndrome who had undergone similar investigations were included as controls.ResultsNinety‐six patients with UC showed evidence of MAC more often than the controls (n = 20) based on biopsy culture (33.3% vs 5.0%, P = 0.011), brush cytology (30.2% vs 5.0%, P = 0.019), and brush culture (36.5% vs 10.0%, P = 0.021). Patients with UC had higher candida colony counts (≥103 CFU/mL) than controls (34.4% vs 5.0%, P = 0.007). Median β‐D‐glucan values were higher in patients with UC than in controls (103.26 pg/mL vs 66.51 pg/mL, P = 0.011). The UC group with MAC had a higher median total Mayo score, C‐reactive protein, fecal calprotectin, β‐D‐glucan, and histological activity than those without MAC.ConclusionsPatients with UC more often show evidence of MAC and a higher candida colony count than controls. The presence of MAC is associated with high disease severity in patients with UC.
Tocilizumab monotherapy for polymyalgia rheumatica: A prospective, single‐center, open‐label study
Authors: Chino Kentaro , Kondo Tsuneo , Sakai Ryota , Saito Shuntaro , Okada Yusuke , Shibata Akiko , Kurasawa Takahiko , Okuyama Ayumi , Takei Hirofumi , Amano Koichi 
Published: October 2019

AbstractObjectivesPolymyalgia rheumatica (PMR) is a systemic inflammatory disease in the elderly of unknown etiology. While glucocorticoids are the mainstay of treatment for PMR, various glucocorticoid‐related adverse events are common. Recently, several studies have reported the efficacy of tocilizumab (TCZ), an anti‐interleukin‐6 receptor antibody, for PMR treatment in addition to an accompanying reduction, or even tapering‐off, of glucocorticoids in some cases. The objective of this study was to elucidate the efficacy of TCZ monotherapy in the absence of glucocorticoids for PMR.MethodWe conducted a 2‐year, prospective, single‐center, open‐label pilot study of TCZ monotherapy in patients with PMR. TCZ (8 mg/kg) was administered at fortnightly intervals for the first 2 months and monthly over the next 10 months. Subsequently, patients were observed for another year without any treatment. The primary endpoints were the remission rates at weeks 12 and 52, and the secondary endpoints were the relapse rate and safety over the total 104 weeks.ResultsThirteen patients were included in this study. Four of these patients achieved remission at week 12 (remission rate 31%). Four patients withdrew from the study due to adverse events (n = 2) and inefficacy (n = 2). At week 52, all 9 patients who had completed the first year achieved remission. Eight patients completed the drug‐free second year, with 7 maintaining remission.ConclusionsTCZ monotherapy is well tolerated and can lead to remission in most patients with PMR in the absence of glucocorticoids.
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Authors: Marín‐Aguilar Fabiola , Lechuga‐Vieco Ana V. , Alcocer‐Gómez Elísabet , Castejón‐Vega Beatriz , Lucas Javier , Garrido Carlos , Peralta‐Garcia Alejandro , Pérez‐Pulido Antonio J. , Varela‐López Alfonso , Quiles José L. , Ryffel Bernhard , Flores Ignacio , Bullón Pedro , Ruiz‐Cabello Jesús , Cordero Mario D. 
Published: October 2019

AbstractWhile NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inflammation. Here, we investigated the molecular mechanisms through which NLRP3 inhibition may attenuate cardiac aging. Ablation of NLRP3‐inflammasome protected mice from age‐related increased insulin sensitivity, reduced IGF‐1 and leptin/adiponectin ratio levels, and reduced cardiac damage with protection of the prolongation of the age‐dependent PR interval, which is associated with atrial fibrillation by cardiovascular aging and reduced telomere shortening. Furthermore, old NLRP3 KO mice showed an inhibition of the PI3K/AKT/mTOR pathway and autophagy improvement, compared with old wild mice and preserved Nampt‐mediated NAD+ levels with increased SIRT1 protein expression. These findings suggest that suppression of NLRP3 prevented many age‐associated changes in the heart, preserved cardiac function of aged mice and increased lifespan.
Analysis of Partial Thromboplastin Times in Patients With Pulmonary Embolism During the First 48 Hours of Anticoagulation With Unfractionated Heparin
Authors: Prucnal Christiana K. , Jansson Paul S. , Deadmon Erin , Rosovsky Rachel P. , Zheng Hui , Kabrhel Christopher 
Published: October 2019

AbstractObjectiveThe objective was to determine the proportion of patients with pulmonary embolism (PE) treated with unfractionated heparin (UFH) who achieved therapeutic activated partial thromboplastin time (aPTT) values within 48 hours of treatment.MethodsRetrospective analysis of a PE response team (PERT) database was performed at a large, urban, academic teaching hospital. Inclusion criteria were adult patients with acute PE for whom the PERT was consulted and who received anticoagulation (AC) with UFH according to guideline standard dosing. aPTT values during 6‐hour time periods during the first 48 hours of AC were collected and analyzed.ResultsA total of 505 patients met inclusion criteria. For patients receiving a bolus and infusion of UFH, the proportions (95% confidence interval [CI]) of patients in the therapeutic range were 19.0% (14.2% to 25.0%) at 12 hours, 26.3% (26.3% to 33.1%) at 24 hours, 28.3% (22.0% to 35.4%) at 36 hours, and 28.4% (20.8% to 37.5%) at 48 hours. For titrated infusion only, the proportions (95% CIs) of patients were 23.3% (16.2% to 32.3%) at 12 hours, 41.4% (31.6% to 51.9%) at 24 hours, 37.0% (26.8% to 48.5%) at 36 hours, and 42.1% (30.2% to 55.0%) at 48 hours. No patient had all therapeutic aPTT values.ConclusionsThe majority of patients with acute PE spend most of their first 48 hours outside of the therapeutic range of AC when treated with guideline standard dosing of UFH. Over half of the patients fail to achieve any therapeutic PTT level within 24 hours of UFH initiation, and no patient had all therapeutic aPTTs. Future research should focus on identifying factors associated with achieving therapeutic AC with UFH.
What do HIV‐positive drug users’ experiences tell us about their antiretroviral medication‐taking? An international integrated literature review
Authors: Ho Iris Szu‐Szu , Holloway Aisha , Stenhouse Rosie 
Published: October 2019

AbstractBackground and aimsHIV‐positive drug users’ poor adherence to antiretroviral regimens can pose a significant and negative impact on individual and global health. This review aims to identify knowledge gaps and inconsistencies within the current evidence base and to measure HIV‐positive drug users’ adherence rates and the factors that influence their adherence.MethodsA search of quantitative and qualitative studies in relation to HIV‐positive drug users’ adherence to antiretroviral treatment was performed using five databases: Applied Social Sciences Index and Abstract (ASSIA), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Embase and PsycINFO (Ovid interface). Relevant studies were retrieved based on the inclusion and exclusion criteria stated in the review. Findings were compared, contrasted and synthesized to provide a coherent account of HIV‐positive drug users’ adherence rates and the factors that influence their adherence.ResultsThe proportion of HIV‐positive drug users who achieved ≥ 95% adherence across the studies varied widely, from 19.3 to 83.9%. Adherence rates changed over the course of HIV treatment. The factors that influenced adherence were reported as follows: stigmatization, motivation, active drug use, accessibility and conditionality of HIV and addiction care, side effects and complexity of treatment regimens, forgetfulness and non‐incorporation of dosing times into daily schedules.ConclusionsHIV‐positive drug users’ medication‐taking is a dynamic social process that requires health professionals to assess adherence to HIV treatment on a regular basis.
Assessment of sexual behaviour and fertility indices in male rabbits following chronic codeine use
Authors: Ajayi A. F. , Akhigbe R. E. 
Published: October 2019

AbstractBackgroundCodeine is the latest trend of drug abuse, particularly in Nigeria and regarded as the gateway to the abuse of other substances.ObjectivesThe present study examined the effects of graded doses of codeine on sexual behaviour and fertility profile.Materials and methodsRabbits were either administered normal saline (0.2 mL), 4mg/kg b.w of codeine (low dose), or 10mg/kg b.w of codeine (high dose) p.o for 6 weeks.Results and discussionFindings of the study showed that codeine administration significantly increased libido as witnessed by significantly short mount latency (ML), intromission latency (IL), post‐ejaculatory interval (PEI) and significantly increased mount frequency (MF), intromission frequency (IF) and ejaculation latency (EL). Furthermore, codeine caused a marked rise in penile reflexes evident by a significant increase in erections, quick flips, long flips and total penile reflexes. However, copulatory efficiency and fertility index were significantly lower in codeine‐treated groups when compared with the control. Serum levels of testosterone were also significantly lower in the treated groups.ConclusionsThe present study demonstrates that codeine‐induced enhancement of sexual performance is via a testosterone‐independent mechanism. It also reveals that although codeine enhances copulatory locomotor activity, it is a potential risk factor for infertility.
Editorial: accelerated infliximab induction—it’s time to settle the debate!
Authors: Chedid Victor G. , Kane Sunanda V. 
Published: October 2019

LINKED CONTENTThis article is linked to Sebastian et al papers. To view these articles, visit https://doi.org/10.1111/apt.15456 and https://doi.org/10.1111/apt.15498.