bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convolutional neural net learns promoter sequence features driving transcription strength
Authors: Leiby Nicholas , Hossain Ayaan , Salis Howard M 
Published: March 2020

Promoters drive gene expression and help regulate cellular responses to the environment. In recent research, machine learning models have been developed to predict a bacterial promoter’s transcriptional initiation rate, although these models utilize expert-labeled sequence elements across a defined set of DNA building blocks. The generalizability of these methods is therefore limited by the necessary labeling of the specific components studied. As a result, current models have not been used to predict the transcriptional initiation rates of promoters with generalized nucleotide sequences. If generalizable models existed, they could greatly facilitate the design of synthetic genetic circuits with well-controlled transcription rates in bacteria.To address these limitations, we used a convolutional neural network (CNN) to predict a promoter’s transcriptional initiation rate directly from its DNA nucleotide sequence. We first evaluated the model on a published promoter component dataset. Trained using only the sequence as input, our model fits held-out test data with R2​ ​= 0.90, comparable to published models that fit expert-labeled sequence elements.We produced a new promoter strength dataset including non-repetitive promoters with high sequence variation and not limited to combinations of discrete expert-labeled components. Our CNN trained on this more varied dataset fits held-out promoter strength with R2​ ​= 0.61. Previously-published models are intractable on a dataset like this with highly diverse inputs. The CNN outperforms classical approach baselines like LASSO on a bag of words for promoter sequence elements (R2​ ​= 0.42).We applied recent machine learning approaches to quantify the contribution of individual nucleotides to the CNN's promoter strength prediction. Learning directly from DNA sequence, our model identified the consensus -35 and -10 hexamer regions as well as the discriminator element as keycontributorstoσ7​0​promoterstrength.Italsoreplicatedafindingthataperfectconsensus sequence match does not yield the strongest promoter.The model's ability to independently learn biologically-relevant information directly from sequence, while performing similarly to or better than classical methods, makes it appealing for further prediction optimization and research into generalizability. This approach may be useful for synthetic promoter design, as well as for sequence feature identification.
Aiming for the Goal with SInE
Authors: Suda Martin 
Published: March 2020

The Sumo INference Engine (SInE) is a well-established premise selection algorithm for first-order theorem provers, routinely used, especially on large theory problems. The main idea of SInE is to start from the goal formula and to iteratively add other formulas to those already added that are related by sharing signature symbols. This implicitly defines a certain heuristical distance of the individual formulas and symbols from the goal.In this paper, we show how this distance can be successfully used for other purposes than just premise selection. In particular, biasing clause selection to postpone introduction of input clauses further from the goal helps to solve more problems. Moreover, a precedence which respects such goal distance of symbols gives rise to a goal sensitive simplification ordering. We implemented both ideas in the automatic theorem prover Vampire and present their experimental evaluation on the TPTP benchmark.
Transformasi Bentuk Fisik pada Tipologi Fasade Masjid Jami’ Malang
Authors: A'yun Qurrotul 
Published: March 2020

Masjid Jami’ Malang merupakan masjid yang mengalami perubahan bentuk tipologi secara dinamis. Secara arsitektural, Masjid Jami’ Malang mengakomodasi beberapa tipologi sekaligus, yaitu tipologi yang menjadi ciri universalitas dari sebuah masjid, serta tipologi yang menjadi ciri lokalitas dari daerah setempat. Padahal masjid pada umumnya hanya mengakomodasi 1 (satu) jenis tipologi saja. Bagaimana Masjid Jami’ Malang dapat menggabungkan beberapa tipologi fasade dan mentransformasikannya ke dalam bentukan-bentukan yang baru inilah, yang menjadi menarik untuk dikaji. Penelitian dilakukan melalui sejumlah kajian literatur dengan pustaka-pustaka yang relevan, serta diperkuat dengan observasi langsung terhadap obyek. Metode yang digunakan untuk mengkaji hal tersebut ialah metode deskriptif analisis. Hasil kajian menyatakan bahwa penggabungan bentuk antara ciri universalitas dan lokalitas, dilakukan dengan cara menampilkan atap kubah (dome), iwan, arches serta minaret secara bertahap sebagai ciri universalitas masjid dunia, dengan tetap mempertahankan atap tajug, serta penggunaan material kayu sebagai ciri kelokalitasan daerah.
Evaluasi Material Radiant Tube Heater Di Unit Refinery Menggunakan Metode Teknik Replika Dan Kekerasan
Authors: Syahril Muhammad , Kurniasih Kurniasih 
Published: March 2020

Tulisan ini dibahas tentang evaluasi materialradianttube refinery heateryang telah beroperasi selama Â± 15 tahun dengan metode teknik replika dan uji kekerasan. Secara visual, tube yang merupakan spesifikasi dari material 1Â¼Cr-Â½Mo-Si telah terdegradasi akibat terekspos pada temperatur tinggi dalam waktu yang lama. Evaluasi dilakukan secara analitis untuk mengetahui kondisi aktual tube dan menjamin kehandalan tube terhadap beban operasi yang akan datang.
Studi ini dilakukan dengan melakukan pemeriksaan visual, struktur mikro dengan teknik replika dan uji kekerasan material dengan alat uji kekerasan portable. Pengamatan pada radianttubemenunjukkan bahwa struktur mikro material tube berupa fasa ferit dan perlit yang mulai terspheroidisasi,batas butir masih cukup jelas, nilai kekerasan minimum sebesar 127 HB (kekerasan brinnell) yang identik dengan nilai kekuatan tarik sebesar 438 MPa.Analisis kekuatan material dari nilai kekerasan mengindikasikan bahwa material tube masih dalam kriteria spesifikasi standar material 1Â¼Cr-Â½Mo-Si, dimana kekuatanstandarnya adalah minimum 415 MPa. Berasarkan analisis struktur mikro dan nilai kekerasan dapat disimpulkan bahwa material tube heater masih layak dan handal untuk difungsikan dalam operasi sesuai kondisi desain.
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Akuntansi Sederhana Bagi Usaha Rumah Tangga Pengolahan Buah Mangrove di Kabupaten Mempawah
Authors: Kurniati Dewi , Dolorosa Eva , Nurliza Nurliza 
Published: March 2020

Mangrove fruits can be used as an alternative food stuffs. Household businesses in Mempawah Regency processed mangrove fruits into products in the form of dodol, syrup, and flour. Nevertheless, the processing done by the community was very simple and required a long time. One disadvantage of household businesses in managing their businesses was the poor financial management, specifically related to the accounting bookkeeping process. This service activity aimed to provide accounting training for household businesses so that they can have better financial management knowledge and procedures. The method used was the accounting training practice. This training activity was participated in by the mangrove fruit processing household business operators which was carried out in Sungai Bakau Besar Laut Village, Siliki Pinyuh Sub-district, Mempawah District. The results of the training showed an increase in the knowledge and abilities of the participants in accounting bookeeping and the participants practiced themselves in their respective businesses. To support the sustainability of this training program, a mentoring program from the government and academia are needed.
Analisis Ekonomi dan Pemasaran Usahatani Cabai Rawit di Kecamatan Labuhan Haji Kabupaten Lombok Timur
Authors: Sari Rina Novita 
Published: March 2020

Cabai rawit (Capsicum fritescens L.) merupakan salah satu komoditas pertanian yang banyak mendapatkan perhatian karena memiliki nilai ekonomis yang cukup tinggi karena hampir semua jenis masakan menggunakan cabai rawit untuk menambah rasa pedas pada masakan, selain itu dapat digunakan sebagai obat-obatan dan lain-lain. Penelitian ini dilakukan untuk mengetahui analisis biaya, penerimaan, pendapatan, efisiensi usahatani, saluran dan efisiensi pemasaran serta masalah yang dihadapi oleh petani cabai rawit di Kecamatan Labuhan Haji Kabupaten Lombok Timur. Penelitian ini dilaksanakan di dua Desa yaitu Desa Penedagandor dan Desa Korleko. Penelitian ini menggunakan metode deskriptif dan pengumpulan data dilakukan dengan wawancara langsung kepada petani dan ditambah dengan data pendukung lain yang dapat menunjang dari studi literatur dan pustaka. Hasil penelitian menunjukkan bahwa biaya dan pendapatan usahatani cabai rawit di Kecamatan Labuhan Haji Kabupaten Lombok Timur adalah sebesar Rp. 8.494.778/LLG atau Rp. 36.668.108/Ha dengan penerimaan sebesar Rp 48.464.917/LLG atau Rp 209.201.079/Ha dan pendapatan sebesar Rp 39.970.139/LLG atau Rp 172.532.971/Ha. R/C ratio usahatani cabai rawit di Kecamatan Labuhan Haji adalah sebesar 5,70 yang berarti bahwa usahatani cabai rawit layak untuk diusahakan karena memiliki nilai R/C ratio ≥ 1. Pemasaran cabai rawit sudah efisien karena share petani lebih dari 60% yaitu 66% dan 73% dengan margin Rp 11.607/kg dan Rp 8.654/kg dan distribusi keuntungan 0,78 dan 0,89. Masalah usahatani yang dihadapi oleh petani cabai rawit di Kecamatan Labuhan Haji yaitu fluktuasi harga, keterbatasan saprodi, hama dan penyakit.
Cryphaea consimilis (Cryphaeaceae, Bryophyta), nueva cita para la Argentina.
Authors: Cottet Agustina C. , Suárez Guillermo M. , Schiavone María M. , Messuti María I. 
Published: March 2020

Cryphaea consimilis Mont. (Cryphaeaceae, Bryophyta) se registra por primera vez para la Argentina, extendiendo su distribución dentro de los bosques subantárticos. Se presenta una descripción breve, discusión, mapa de distribución e ilustración de la especie. En este trabajo se designa un lectotipopara la especie.
Pattern of glomerular diseases in biopsy proven native kidney in Western Nepal
Authors: Maskey Abhishek , Lamsal Lekhnath 
Published: March 2020

Background and Aims: Kidney biopsy is decisive while evaluating for the diagnosis of glomerular, vascular, tubulointerstitial and genetic diseases. There is paucity of data on prevalence and pattern of various types of kidney diseases in Nepalese population. We describe various types of kidney diseases in patient population undergoing kidney biopsy at our centre.
Methods: This is a prospective analysis of all patients, who underwent percutaneous renal biopsy at Manipal teaching hospital, over a duration of 30 months, i.e. August 2017 to January 2019. All kinds of kidney disease patients were included for kidney biopsy, irrespective of their clinical syndromes and underlying diagnosis.
Results: A total of 175 consecutive biopsies were analyzed. The mean age of the patient was 35 } 15 years. Majority of the biopsy performed were in females. The majority of biopsy cases were age between 21-30 years of age. The youngest case to undergo renal biopsy was a child with asymptomatic isolated hematuria. The most frequent histological pattern observed in our study was IgA nephropathy (34.6%), followed by Focal segmental glomerulosclerosis (15.45%) and Membranous nephropathy (14.85%). Regarding complication macroscopic hematuria was seen in 15 (8.5%) cases and 8 (4.5%) cases had perinephric hematoma. There was no death related to renal biopsy.
Conclusion: IgA nephropathy was the commonest histological pattern. Subnephrotic proteinuria was the commonest indication for biopsy. Complication of kidney biopsy is rare and considered safe procedure in clinical practice to determine diagnosis, prognosis and treatment.
Complications and predictors of diagnostic yield of endobronchial forceps biopsy in visible lesions
Authors: Shrestha Bishow Kumar , Adhikari Shital , Thakur Binay Kumar , Kadaria Dipen , Tamrakar Kishore Kumar , Devkota Mukti 
Published: March 2020

Background: Fiberoptic bronchoscopy is an important and relatively safe procedure for evaluation of various pulmonary diseases. Endobronchial forceps biopsy is commonly performed sampling technique for visible lesions in tracheobronchial tree. Diagnostic yield of biopsy depends upon lesion type and the number of biopsy samples taken. This study aimed to evaluate the complications and diagnostic yield of endobronchial forceps biopsy in visible lesions and correlate the number of biopsy samples taken with the yield.
Methods: This was an observational study conducted at two tertiary care hospitals in Chitwan; Chitwan Medical College Teaching Hospital and B P Koirala Memorial Cancer Hospital. One hundred and forty patients who underwent endobronchial forceps biopsy of bronchoscopically visible lesions were included. Complications and diagnostic yield of the biopsy samples and its correlation with number of biopsies taken were evaluated.
Results: The common complications observed were transient drop in saturation > 4% (22%) and mild bleeding (9.9%). The net diagnostic yield was 67.4% that significantly improved with an increase in the number of biopsies taken. The yield was better for exophytic growths compared to submucosal/ mucosal lesions (83.7% vs. 57%, OR = 8.1 (2.2 – 29.9), P<0.001). The association of improved yield with increased number of biopsy was more pronounced in exophytic growths compared to submucosal/mucosal lesions.
Conclusion: Endobronchial forceps biopsy is a safe procedure that gives a good diagnostic yield in bronchoscopically visible lesions, provided adequate number of biopsy sample are taken. The probability of getting a positive yield is high in exophytic growths.
Competitiveness of Russian Universities in the Global System of Higher Education: Quantitative Analysis
Authors: Endovitsky D. A. , Korotkikh V. V. , Voronova M. V. 
Published: March 2020

Purpose– quantitative analysis and identification of determinants of Russian universities’ global competitiveness.Methods. Parametric and non-parametric methods for data analysis and machine learning.Results. The authors figured out the hidden determinants of international competitiveness of Russian universities and the national educational system of the Russian Federation. We proposed four working hypotheses. (1) The positions of Russian universities in the international QS ranking are different for metropolitan and regional universities. (2) The positions of Russian universities in the international QS ranking depend on the status of universities. (3) The positions of Russian universities in the international QS ranking differ depending on the participation of universities in the Russian Academic Excellence Project “5-100”. (4) The positions of Russian universities in the international QS ranking are different depending on the level of annual university income. We obtained dataset for the study from the analytical materials of the British consulting company QS, as well as information and analytical materials from the results of monitoring the effectiveness of educational institutions of higher education in the Russian Federation.Conclusions. In the empirical part, we have established the significance of the university geographical location influence on its international competitiveness. We have found a high competitiveness level of Moscow and St. Petersburg universities. The international market for educational services does not give preference to universities with the status of a «national research» or «federal». Increased state funding, burdened with approved roadmaps of the Project Office of the Program 5-100, contributes to competitiveness only in the regional educational markets, which is still not enough to strengthen the global international competitiveness of Russian universities and the national educational system of the Russian Federation. Although the level of universities annual income was a significant factor in international competitiveness, university management efficiency played an important role, not only increased funding. Universities with greater institutional management freedom will have greater international competitiveness.
PHARMACOGNOSTICAL, PHYSICOCHEMICAL AND HPTLC EVALUATION OF AMRUTADHYA GUGGULU A POLYHERBAL FORMULATION FOR PHARMACEUTICAL STANDARDIZATION
Authors: Zala Divya , Dilip Prajapati  , Anup Thakar  , Harisha CR  , V.J.Shukla  
Published: March 2020

Background: Standardization of herbal formulation is needed in order to assess of quality of drug. Maintaining the quality standard of a polyherbal formulation is a difficult task. In the era of increasing demand for traditional medicines, maintaining quality standards is the need of the hour.
Aim: The present work was carried out to standardize the finished product Amrutadhya Guggulu to confirm its identity, quality and purity.
Material and Method: Amrutadhya Guggulu is mentioned in the treatment of Sthaulya (Obesity), and it was prepared according to the method as described in Chakradatta. Amrutadhya Guggulu powder was evaluated for its pharmacognostic and pharmaceutical analysis. It contains drug like Guduchi, Ela, Kutaja Phala, Kutaj twaka etc.
Result: Epicarp and stone cell of Vidanga, silica deposition of Amalaki, oil globule of Ela etc were the characteristic features observed in the microscopy of Amrutadhya Guggulu powder .Results found in pharmaceutical parameters of Amrutadhya Guggulu powder like Loss on drying8.07% w/w, Ash value 3.07% w/w, Water soluble extract 22.5 % w/w, alcohol soluble extract 13.44%w/w and pH 4
Conclusion: The Obtained values of all parameters for the finish product can be adopted to set down new standards.
Keywords: Amrutadhya Guggulu, HPTLC, Pharmacognostical, Pharmaceutical analysis
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN BENDUNGAN ASI DI KLINIK KASIH IBU DELI SERDANG TAHUN 2017
Authors: Asrul Asrul Asrul , Pratiwi Debby 
Published: March 2020

ASI merupakan gizi sangat ideal dengan komposisi seimbang akantetapi, pemberian ASI tidak selamanya dapat berjalan normal salah satunya karena bendungan air susu yaitu pembengkakan pada payudara karena peningkatan aliran vena dan limfe menurut data WHO tahun 2013 di Amerika Serikat sebanyak 87,05%. perempuan menyusui mengalami bendungan asi data SDKI tahun 2015 sebanyak 37,12% ibu nifas mengalami bendungan asi. Dari data survey awal didapat, dari 10 orang ibu nifas bahwa 6 orang mengalami bendungan asi. Tujuan penelitian untuk mengetahui Faktor-Faktor Yang Berhubungan Dengan Kejadian Bendungan ASI Di Klinik Kasih Ibu Deli Serdang Tahun 2017. Jenis penelitian survei analitik dengan desain cross sectional. Lokasi penelitia Klinik Kasih Ibu Deli Serdang. Teknik pengambilan sampel adalah total population sebanyak 34 orang. Teknik pengumpulan data menggunakan kuesioner. Data dianalisis menggunakan uji Chi-Square yaitu analisis univariat dan analisis Bivariat. Hasil penelitian menunjukkan Hasil uji statistik menggunakan uji chi square, diperoleh hasil perhitungan pendidikan (p value = 0,004 < α = 0,05), pengetahuan (p value = 0,002 < α = 0,05), paritas (p value = 0,003 < α = 0,05), maka Ho ditolak dan Ha diterima. Kesimpulannya terdapat Pengaruh yang Berhubungan Dengan Kejadian Bendungan ASI Di Klinik Kasih Ibu Deli Serdang Tahun 2017. Disarankan tenaga kesehatan untuk memberikan penyuluhan tentang kejadian bendungan ASI melalui kerjasama lintas program dengan lembaga terkait. ABSTRACTBreast milk is not always able to walk normally one of them because milk dams that is swelling in the breast due to increased venous flow and lymph velopes according to WHO data 2013 in the United States as much as 87.05%. of breastfeeding women suffered from data damages of ICI data in 2015 as much as 37.12% of postpartum women suffered dams. From preliminary survey data obtained, from 10 postpartum mothers that 6 people suffered dam ation. The purpose of research to determine Factors Associated With Breastfeeding Incidence At Deli Serdang Ibu Bersih Clinic Year 2017. Type of research analytic survey with cross sectional design. Location researcher Klinik Kasih Ibu Deli Serdang. Sampling technique is total population of 34 people. Data collection techniques using questionnaires. Data were analyzed using Chi-Square test that is univariate analysis and Bivariat analysis. The result of the research shows that the result of statistical test using chi square test, obtained the calculation of education (p value = 0,004 <α = 0,05), knowledge (p value = 0,002 <α = 0,05), parity (p value = 0,003 < = 0,05), then Ho is rejected and Ha accepted. In conclusion there is Influence Associated with Breastfeeding Incidence At Deli Serdang Deli Health Clinic Year 2017. Suggested health workers to provide counseling about the incidence of milk dam through cross-program cooperation with related institutions.
ВЛАСТИВОСТІ БУКТРЕЙЛЕРА: УКРАЇНСЬКИЙ ТА СВІТОВИЙ ДОСВІД
Authors: Sizova K. , Alekseenko N. , Khmil-Chupryna V. 
Published: March 2020

<div><p><em>The purpose of the study is to analyze the aesthetic and cultural-educational peculiarities of the booktrailer as a phenomenon of publishing. The paper provides a comparative analysis of Ukrainian and foreign booktrailers in order to identify conceptual differences. The methodology of the study is the use of common scientific methods of analysis and synthesis, comparison and generalization. The booktrailer has long been studied in the paradigm of marketing and advertising or librarianship, which left it beyond the attention of scholars to understand it as an aesthetic phenomenon. In the process of presenting the main paper theses, the means of formal, figurative, stylistic and comparative analysis were used, which made it possible to reveal the aesthetic and cultural-educational peculiarities of Ukrainian and foreign booktrailers.</em></p></div><p><em>The scientific novelty of the paper is the comprehensive study of the booktrailer as a phenomenon of publishing. The comparative analysis of Ukrainian and world book trailers revealed fundamental differences caused by the features of creation (developers and purpose of creation). The current state of development of the booktrailer in Ukraine is characterized by the fact that it is created mainly by fans. Ukrainian booktrailers are currently mostly book-based presentations and descriptive features. Today, the most common in Ukraine is a booktrailer based on book illustrations and slideshows of works. In this case, the contents of the books contents are mechanically transferred to the monitor. In turn, foreign booktrailers are created as a figurative audiovisual series designed to convey the atmosphere of a work of art, to give the impression of a book. If in foreign booktrailers the aesthetic function comes to the fore, then Ukrainian analogues tend to emphasize cultural and educational.</em></p><p><strong><em>Key words:</em></strong><em> booktrailer, book promotion, publishing phenomenon, aesthetic peculiarities, cultural and educational function</em>.</p>