bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exclusionary conduct in data-driven markets: limitations of data sharing remedy
Authors: Kathuria Vikas , Globocnik Jure 
Published: November 2019

Abstract
The natural consequence of finding an infringement of Article 102 TFEU is to offset the harm to consumer welfare by restoring competition through effective remedies. As big data constitutes the most vital resource in data-driven markets, a dominant undertaking can exclude its rivals from accessing user data and thus deprive them of scale in markets that are characterized by network effects. Indeed, the European Commission found Google guilty of excluding its rivals in the Android licencing case by adopting this strategy. The Commission, however, did not impose any data sharing remedy. This article analyses the viability of mandatory data sharing as a remedy to restore competition in the affected market. It approaches this research question from both theoretical and practical standpoints. It analyses the viability of a mandatory data sharing remedy from a legal, economic, and technological perspective. A separate section makes an assessment of such a remedy within the framework of the GDPR. Based on this investigation, this article concludes that mandatory data sharing is not the optimal solution to remedy loss to consumer welfare.
Systematic review of pre-operative planning modalities for correction of acetabular dysplasia
Authors: Acuña Alexander J , Samuel Linsen T , Mahmood Bilal , Kamath Atul F 
Published: November 2019

AbstractAcetabular dysplasia, related to developmental dysplasia of the hip, causes the abnormal distribution of hip joint forces. Surgical correction of acetabular dysplasia involves repositioning the acetabulum to achieve improved coverage of the femoral head. However, ideal placement of the acetabular fragment is challenging, and has led to an increased interest in pre-operative planning modalities. In this study, we used the PubMed and EBSCO host databases to systematically review all the modalities for pre-operative planning of acetabular dysplasia proposed in the current literature. We included all case-series, English, full-text manuscripts pertaining to pre-operative planning for congenital acetabular dysplasia. Exclusion criteria included: total hip arthroplasty (THA) planning, patient population mean age &gt;35, and double/single case studies. A total of 12 manuscripts met our criteria for a total of 186 hips. Pre-operative planning modalities described were: Amira (Thermo Fischer Scientific; Waltham, MA, USA) 12.9%, OrthoMap (Stryker Orthopaedics; Mahwah, NJ, USA) 36.5%, Amira + Biomechanical Guidance System 5.9%, Mills et al. method 16.1%, Klaue et al. method 16.1%, Armand et al. method 6.5%, Tsumura et al. method 3.8% and Morrita et al. method 2.2%. As a whole, there was a notable lack of prospective studies demonstrating these modalities’ efficacy, with small sample sizes and lack of commercial availability diminishing their applicability. Future studies are needed to comprehensively compare computer-assisted planning with traditional radiographic assessment of ideal osteotomy orientation.
Early separation of omphalopagus conjoined twins: a case report from Syria
Authors: Omran Ammar , Nassif Mhmmad , Salhab Nabila , Abdo Aras , Almahmod Alkhalil Mohammad Ahmad , Taishori Norma , Dayoub Adnan 
Published: November 2019

Abstract
Omphalopagus twins are one of many forms of conjoined twins sharing part of the gastrointestinal system and abdominal wall. This type of twins has the best chance of survival if successfully separated. Surgical approaches in these cases are generally preferably elective, but sometimes separation may be urgently needed due to life-threatening complications, such as hemodynamic instability, death of either twin, necrotizing enterocolitis, among many others. We report a case of successfully separated omphalopagus twins at day two of life.
Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast
Authors: Taglini Francesca , Chapman Elliott , van Nues Rob , Theron Emmanuelle , Bayne Elizabeth H 
Published: November 2019

Abstract
Constitutive domains of repressive heterochromatin are maintained within the fission yeast genome through self-reinforcing mechanisms involving histone methylation and small RNAs. Non-coding RNAs generated from heterochromatic regions are processed into small RNAs by the RNA interference pathway, and are subject to silencing through both transcriptional and post-transcriptional mechanisms. While the pathways involved in maintenance of the repressive heterochromatin state are reasonably well understood, less is known about the requirements for its establishment. Here, we describe a novel role for the post-transcriptional regulatory factor Mkt1 in establishment of heterochromatin at pericentromeres in fission yeast. Loss of Mkt1 does not affect maintenance of existing heterochromatin, but does affect its recovery following depletion, as well as de novo establishment of heterochromatin on a mini-chromosome. Pathway dissection revealed that Mkt1 is required for RNAi-mediated post-transcriptional silencing, downstream of small RNA production. Mkt1 physically associates with pericentromeric transcripts, and is additionally required for maintenance of silencing and heterochromatin at centromeres when transcriptional silencing is impaired. Our findings provide new insight into the mechanism of RNAi-mediated post-transcriptional silencing in fission yeast, and unveil an important role for post-transcriptional silencing in establishment of heterochromatin that is dispensable when full transcriptional silencing is imposed.
Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development
Authors: Aprato Jessica , Sock Elisabeth , Weider Matthias , Elsesser Olga , Fröb Franziska , Wegner Michael 
Published: November 2019

Abstract
Oligodendrocytes generate myelin in the vertebrate central nervous system and thus ensure rapid propagation of neuronal activity. Their development is controlled by a network of transcription factors that function as determinants of cell identity or as temporally restricted stage-specific regulators. The continuously expressed Sox10 and Myrf, a factor induced during late development, are particularly important for terminal differentiation. How these factors function together mechanistically and influence each other, is not well understood. Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 on genes that are essential during earlier phases of oligodendroglial development. By characterization of the exact DNA-binding requirements of Myrf, we furthermore show that cooperative activation is a consequence of joint binding of Sox10 and Myrf to the same regulatory regions. In contrast, inhibition of Sox10-dependent gene activation occurs on genes that lack Myrf binding sites and likely involves physical interaction between Myrf and Sox10 followed by sequestration. These two opposite activities allow Myrf to redirect Sox10 from genes that it activates in oligodendrocyte precursor cells to genes that need to be induced during terminal differentiation.
B-cell treatment in ANCA-associated vasculitis
Authors: Karras Alexandre , Lazareth Hélène , Chauvet Sophie 
Published: November 2019

AbstractThe pivotal role of B-cells in ANCA-associated vasculitis has been suggested by experimental data that demonstrate the direct pathogenicity of ANCAs. Rituximab (RTX), an anti-CD20 monoclonal antibody that targets B-cells, has proven its efficacy for induction of remission in severe ANCA vasculitis. RTX is equivalent to CYC for induction of remission, and is probably superior in relapsing patients. Long-term B cell depletion by prolonged RTX treatment has been shown to significantly reduce the relapse rate, when compared with AZA maintenance therapy. Biomarkers, such as B-cell subpopulations or ANCA monitoring, may help the clinician to determine the optimal dose and duration of RTX therapy.
Disproportionality in Juvenile Justice Diversion: An Examination of Teen Court Peer-Derived Consequences
Authors: Stalker Katie Cotter 
Published: November 2019

AbstractJuvenile justice diversion programs, such as Teen Court (TC), represent an alternative to traditional juvenile justice responses to youth misbehavior and delinquency. However, although TC represents a potential strategy to address disproportionate minority contact, there is a dearth of research examining the extent to which TC programs are racially equitable. To address this gap, the current study examines racial disproportionality in a TC program in Arizona. Results indicated that in a diverse sample of youths involved in a TC program in Arizona, youths who identified as Latinx or American Indian were more likely to receive a severe consequence from the peer jury compared with their non-Latinx, white counterparts. Multiracial youths were less likely to receive a severe consequence compared with white youths. A hierarchical regression model indicated that offense-related variables explained the largest proportion of variance in number of consequence hours assigned. However, disparities for Latinx and American Indian youths compared with non-Latinx, white youths persisted after controlling for other demographics, type of offense, prior offenses, and additional charges. The results of the current study are the first to document racial disparity in the TC process.
DNA sequence repeats identify numerous Type I restriction‐modification systems that are potential epigenetic regulators controlling phase‐variable regulons; phasevarions
Authors: Atack John M. , Guo Chengying , Yang Long , Zhou Yaoqi , Jennings Michael P. 
Published: November 2019

AbstractOver recent years several examples of randomly switching methyltransferases, associated with Type III restriction‐modification (R‐M) systems, have been described in pathogenic bacteria. In every case examined, changes in simple DNA sequence repeats result in variable methyltransferase expression and result in global changes in gene expression, and differentiation of the bacterial cell into distinct phenotypes. These epigenetic regulatory systems are called phasevarions, phase‐variable regulons, and are widespread in bacteria, with 17.4% of Type III R‐M system containing simple DNA sequence repeats. A distinct, recombination‐driven random switching system has also been described in Streptococci in Type I R‐M systems that also regulate gene expression. Here, we interrogate the most extensive and well‐curated database of R‐M systems, REBASE, by searching for all possible simple DNA sequence repeats in the hsdRMS genes that encode Type I R‐M systems. We report that 7.9% of hsdS, 2% of hsdM, and of 4.3% of hsdR genes contain simple sequence repeats that are capable of mediating phase variation. Phase variation of both hsdM and hsdS genes will lead to differential methyltransferase expression or specificity, and thereby the potential to control phasevarions. These data suggest that in addition to well characterized phasevarions controlled by Type III mod genes, and the previously described Streptococcal Type I R‐M systems that switch via recombination, approximately 10% of all Type I R‐M systems surveyed herein have independently evolved the ability to randomly switch expression via simple DNA sequence repeats.
Transesophageal echocardiography in minimally invasive cardiac surgery
Authors: Prempeh Agya B.A. , Scherman Jacques , Swanevelder Justiaan L. 
Published: November 2019

Purpose of reviewTransesophageal echocardiography (TEE) has made its way into the cardiac surgery realm and spurred the development of many interventions. In the domain of minimally invasive cardiac surgery (MICS), TEE has become central to reducing cardiovascular complications.Recent findingsReal-time three-dimensional TEE is a key contributor to the safe and precise deployment of the PASCAL mitral valve repair system, which is showing great potential in ongoing studies. The current data on outcomes of transcatheter aortic valve replacement show that preprocedural three-dimensional TEE and multidetector computed tomography (CT) perform similarly in aortic root assessment. Three-dimensional color Doppler TEE has been suggested to be more appropriate in quantifying residual mitral regurgitation and evaluating the success of surgical or percutaneous closure. A three-dimensional TEE-derived aortomitral angle may be valuable in predicting and detecting dynamic left ventricular outflow tract obstruction, thereby enhancing the safety of transcatheter mitral valve replacement.SummaryAdvanced imaging modalities are essential for the sustained growth of MICS, particularly with the evolution of novel transcatheter systems. These techniques rely on exceptional imaging quality at all stages of the perioperative period to modify surgical-risk and improve patient outcomes. TEE has the additional benefit of providing real-time information on intrathoracic structures to guide intraoperative management.
Bridging the Communication Gap
Authors: Griffith Andy , Haverstick Stacy , Blissick Deb , Colaianne Teresa , Shields Heidi , Johnson Caty , Lucier Rená , Melong Mary Jane , Kasten Kristin , Knott Kevin 
Published: November 2019

Background
As of December 31, 2016, in the United States, 22 866 patients received left ventricular assist devices (LVADs) (J Heart Lung Transplant. 2017;36(10):1080-1086). First responders are generally unfamiliar with LVAD equipment functionality (J Heart Lung Transplant. 2018;37(4):S275). When a patient has an emergency either clinically or with a controller alarm or failure, speaking with ventricle assist device (VAD)–trained personnel is imperative to the prevention of adverse events. Starting February 2017, an LVAD program totaling 181 patients at a large teaching hospital changed their afterhours process to reduce wait time between patient call and talking to VAD-trained personnel to increase patient safety and patient satisfaction.

Methods
The Plan-Do-Check-Act quality improvement method was used to evaluate this project from February 2017 to July 2018 by the program's clinical information analyst. An afterhours summary of telephone interactions between VAD program clinicians (VAD coordinators, physician assistants, and nurse practitioner) was used to analyze the use of the “VAD Emergency Line.” An annual patient satisfaction survey was completed to analyze patient satisfaction of the VAD Emergency Line.

Interventions
Review of the afterhours summary was conducted to determine the use of the VAD Emergency Line. The process of afterhours patient calls was changed so that calls are answered immediately by a 24-hour LVAD-trained medical ambulance service, called VAD Emergency Line. Patient use of the VAD Emergency Line was continuously assessed. In November 2017, it was recognized that only 57% of patient calls used the VAD Emergency Line, and further intervention was needed. In November 2017, patients were provided visual reminders to ensure compliance.

Results
Seventeen months after the implementation of the VAD Emergency Line, 92% of patient's afterhours calls were through the VAD Emergency Line. Although there was no statistical significance found, there was clinical significance. Since the implementation of the VAD Emergency Line, patient use of the VAD Emergency Line increased 56% from March 2017 to July 2018. There have been zero adverse safety events. Sixty-one percent of patients strongly agreed to the question “You are able to communicate emergent needs after hours (VAD Emergency Line)?

Conclusion
Implementation of the LVAD Emergency Line has improved communication between patients in the outpatient setting. This increased patient safety by allowing patients to speak to LVAD-trained first responders and VAD coordinator personnel immediately without ever being put on hold. This communication process can be applied to other clinical programs.
Neonatal Compartment Syndrome as a Result of Thromboembolic Event
Authors: Zajac Jocelyn C. , Mantilla-Rivas Esperanza , Tilt Alexandra , Bryant Justin R. , Oh Albert K. , Rogers Gary F. 
Published: November 2019

Summary:
Neonatal compartment syndrome is a rare condition characterized by progressive limb ischemia and tissue necrosis manifesting at birth or in the immediate postpartum period. Early recognition of clinical features and immediate surgical intervention offer the best prognosis, but unfamiliarity with this uncommon entity often results in delayed diagnosis and catastrophic consequences, including limb amputation. We present a case in a preterm neonate who developed a proximal arterial thrombus after sustaining limb ischemia in utero. This case demonstrated that even delayed treatment with appropriate therapy can result in salvage of the limb. Clinicians should be aware of the characteristic skin findings and institute appropriate measures to determine the presence or absence of compartment syndrome.
Left ventricular mass and incident out-of-office hypertension in a general population
Authors: Cuspidi Cesare , Facchetti Rita , Quarti-Trevano Fosca , Sala Carla , Tadic Marijana , Grassi Guido , Mancia Giuseppe 
Published: November 2019

Aim:
Findings regarding the association of left ventricular mass (LVM) and new-onset hypertension are based on blood pressure measured in the office. We sought to assess the value of LVM in predicting in-office and out-of-office incident hypertension in members of the general population enrolled in the Pressioni Monitorate E Loro Associazioni study.

Methods:
The study included participants with normal office (n = 792), home (n = 714) and 24-h (n = 825) ambulatory blood pressure (ABP) at baseline evaluation who had a readable echocardiogram at entry and at the end of follow-up. Each normotensive group was divided into quartiles of LVM indexed (LVMI) to height2.7.

Results:
Over a follow-up of 148 months cumulative incidence of new office, home and 24-h ABP hypertension were 35.9, 30.7 and 36.1%, respectively. In fully adjusted models (including age, sex, BMI change during follow-up, baseline serum glucose, creatinine, total cholesterol office, home and 24-h SBP and DBP). higher LVMI values (i.e. the highest vs. the lowest quartile) were independently associated with an increased risk of home [odds ratio (OR) = 2.14, 95% confidence interval (CI) 1.21–3.77, P = 0.008] and 24-h ABP hypertension (OR = 1.70, 95% CI 1.05–2.76, P = 0.03). This was not the case for new-onset office hypertension (OR = 1.61, 95% CI 0.94–2.74, P = 0.07).

Conclusion:
Our study provides the first evidence that in normotensive individuals the magnitude of LVMI is independently associated with the risk of incident out-of-office hypertension.
Urinary tract infection in patients with spinal cord injury after urodynamics under fosfomycin prophylaxis: a retrospective analysis
Authors: Amaral Daniela M. , Pereira Ana Margarida V. C. , Rodrigues Margarida R. , Gandarez Maria de Fátima L. , Cunha Maria R. , Torres Marta S. R. 
Published: November 2019

Abstract

Background:
Urinary tract infection (UTI) is a common complication of spinal cord injury (SCI). Urodynamic testing is widely used for characterization of vesico-sphincteric dysfunction and for therapeutic orientation. As an invasive procedure, the risk of UTI is increased so, in some medical centers, antibiotic prophylaxis is instituted. Fosfomycin is one of the antibiotics used.

Objective:
The aim of this study was to evaluate the incidence of UTI after urodynamics in patients with SCI, under fosfomycin prophylaxis.

Methods:
Retrospective analysis was performed on patients with SCI, admitted to a rehabilitation center between January 2016 and June 2017, who underwent urodynamics studies under fosfomycin prophylaxis. Demographic data, risk factors for UTI—bacteriuria before urodynamics, high residual volume (>100 mL), bladder emptying method, vesico-sphincteric dyssynergia, and detrusor hyperactivity were analyzed. The incidence of UTI after urodynamics was evaluated.

Results:
The study included 84 patients, predominantly men 55 (65.5%). The mean age of the patients was 55.6 (18.9). Eleven (22.5%) had vesico-sphincteric dyssynergia, 32 (65.3%) detrusor hyperactivity and 22 (44.9%) had a high residual volume. Thirty-seven (44.1%) had asymptomatic bacteriuria before the urodynamics. Urinary complaints suggestive of UTI after urodynamics were observed in 2(2.4%) of patients, without significant bacteriuria and identification of bacterial agent.

Conclusions:
The incidence of UTI after invasive procedures is reported between 3% and 20% in the literature, so antibiotic prophylaxis has been instituted, although controversial. In the study, in none of the patients the diagnosis of UTI was confirmed. Fosfomycin prophylaxis may have been important in reducing the incidence of UTI.
Frailty and Neurocognitive Impairment: Impacts on Quality of Life in HIV
Authors: Rubtsova Anna A. , Sabbag Samir , Sundermann Erin , Nguyen Annie L. , Ellis Ronald J. , Moore David J. , Letendre Scott , Jeste Dilip V. , Marquine María J. 
Published: November 2019

Abstract
Little is known about the effects of aging-related conditions on health-related quality of life (HRQOL) among people living with HIV (PLWH). The purpose of our study was to examine the independent effects of neurocognitive impairment (NCI) and frailty and the interactive effects with HIV serostatus on HRQOL. Our sample consisted of 121 adults (63 PLWH and 58 HIV-uninfected) participating in the Multi-Dimensional Successful Aging among HIV-Infected Adults study at the University of California, San Diego. HRQOL was measured with the Medical Outcome Study 36-Item Short Form Health Survey scale. We found that frailty was significantly associated with HRQOL (p < .001) in the overall sample, and this effect was significantly stronger for PLWH than HIV-uninfected adults. NCI was not significantly associated with HRQOL in our sample. Frailty may be a particularly important factor in HRQOL for PLWH, highlighting the need for prevention and intervention strategies to mitigate the risks for frailty.
Professional Recognition at Work
Authors: Renger Daniela , Miché Marcel , Casini Annalisa 
Published: November 2019

Objective:The present research systematically investigates the role of recognition experiences at work as a protective factor for burnout.Method:In two cross-sectional studies (N = 328 andN = 220) with employees we measured via online questionnaires three forms of recognition (achievement-based social esteem, equality-based respect, and need-based care) from coworkers and supervisors as predictors and burnout among employees as outcome.Results:Using multiple regression analyses, Study 1 provided initial evidence that both supervisor and coworker recognition were negatively associated with employees’ burnout. Study 2 further demonstrated that whereas respect experiences were especially crucial for lowering emotional exhaustion, care was primarily linked to reduced depersonalization and esteem to heightened personal accomplishment.Conclusion:We discuss how positive recognition experiences can be fostered in organizations in order to buffer the negative effects burnout can cause.