bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug‐resistant temporal lobe epilepsy and comorbid depression
Authors: D’Alessio Luciana , Mesarosova Lucia , Anink Jasper J. , Kochen Silvia , Solís Patricia , Oddo Silvia , Konopka Hector , Iyer Anand M. , Mühlebner Angelika , Lucassen Paul J. , Aronica Eleonora , van Vliet Erwin A. 
Published: July 2020

AbstractObjectiveDepressive disorders are common among about 50% of the patients with drug‐resistant temporal lobe epilepsy (TLE). The underlying etiology remains elusive, but hypothalamus‐pituitary‐adrenal (HPA) axis activation due to changes in glucocorticoid receptor (GR) protein expression could play an important role. Therefore, we set out to investigate expression of the GR in the hippocampus, an important brain region for HPA axis feedback, of patients with drug‐resistant TLE, with and without comorbid depression.MethodsGR expression was studied using immunohistochemistry on hippocampal sections from well‐characterized TLE patients with depression (TLE + D, n = 14) and without depression (TLE − D, n = 12) who underwent surgery for drug‐resistant epilepsy, as well as on hippocampal sections from autopsy control cases (n = 9). Video–electroencephalography (EEG), magnetic resonance imaging (MRI), and psychiatric and memory assessments were performed prior to surgery.ResultsAbundant GR immunoreactivity was present in dentate gyrus granule cells and CA1 pyramidal cells of controls. In contrast, neuronal GR expression was lower in patients with TLE, particularly in the TLE + D group. Quantitative analysis showed a smaller GR+ area in TLE + D as compared to TLE − D patients and controls. Furthermore, the ratio between the number of GR+/NeuN+ cells was lower in patients with TLE + D as compared to TLE − D and correlated negatively with the depression severity based on psychiatric history. The expression of the GR was also lower in glial cells of TLE + D compared to TLE − D patients and correlated negatively to the severity of depression.SignificanceReduced hippocampal GR expression may be involved in the etiology of depression in patients with TLE and could constitute a biological marker of depression in these patients.
Emerging role of local and extended range molecular structures on functionalities of topological phases of (Na2O)x(P2O5)100‐x glasses using Raman scattering and modulated DSC
Authors: Mandal Avik , Gogi Vamshi Kiran , Mohanty Chandi , Chbeir Ralph , Boolchand Punit 
Published: July 2020

AbstractRaman scattering is a powerful probe of local structure (LS) of glasses. In Sodium Phosphate Glasses (SPGs), we show that both LS composed of Qn species and Extended Range Structures (ERS) composed of Long Chains (LCs), Large Rings (LRs), and Small Rings (SRs) can be decoded by Raman scattering. The trimodal distribution of P‐Oterminal stretch modes of Q2 species and P‐Obridging at x < 50% are manifestations of these ERS. These two pairs of triads of modes are uniquely identified with Q2 units present in either LCs, or LRs, or SRs. The existence three phases of c‐NaPO3 composed of 3‐membered rings, 6‐membered rings, and infinitely long chains has facilitated the identification. The Intermediate Phase (IP) in SPGs extends in the 37.5 < x < 46.0% range, the Stressed‐rigid Phase in the 46.0% < x < 50%, and the Flexible Phase in the 18% < x < 37.5% range of soda. We show the IP consists predominantly of LCs (82%), with a minority of LRs (15%) and SRs (3%). The LR‐ and SR‐fractions increase measurably in the non‐IP phases. The structural finding is in harmony with the high configurational entropy of the IP glasses that leads aging to be qualitatively suppressed.
Structure promoted electrochemical behavior and chemical stability of AgI‐doped solid electrolyte in sulfide glass system
Authors: Ma Baochen , Jiao Qing , Zhang Yeting , Lin Changgui , Zhang Xianghua , Ma Hongli , Dai Shixun 
Published: July 2020

AbstractIon‐conducting chalcogenide glass is a promising solid electrolyte with excellent conductivity and energy density for all‐solid‐state batteries. A suitable ionic channel for carriers in the amorphous network is urgently needed. In this work, the structural evolution of co‐doped metal cations (Ge and Ga) in the glass matrix and its influence on electrochemical behavior were studied using a series of GexGa16‐xSb64S128‐40AgI glass samples. The macroscopic properties of samples were examined by X‐ray diffraction (XRD), differential scanning calorimetry (DSC), and Raman tests. The electrochemical behavior of samples was investigated by AC impendence spectroscopy and cyclic voltammetry (CV) measurement. Furthermore, a deliquescence experiment was applied for the chemical stability test of glass samples. The ionic conductivity of samples was developed by adding Ga components. Notably, the electrochemical window of electrolytes was remarkably wide at approximately 5 V. The resistance of samples to humidity was characterized by the decreased Raman peaks. Analysis results show that the Ga‐related bonding structure evidently increased the chemical stability compared with the non‐Ga sample. This work provides an insight into the effective and stable ions transport, especially in the Ge(Ga)SbS glass system. These results promote the further investigation of sulfide solid electrolytes and practical application of all‐solid‐state batteries.
Chiropteran metacommunity structure in the Atlantic Forest of South America
Authors: Stevens Richard D. , Stuhler John D. , Grimshaw Jenna R. 
Published: July 2020

AbstractAimSpatial patterns of local species composition are shaped by dispersal ability. Here we examine the effects of dispersal ability on metacommunity structure of bats throughout the Atlantic Forest of South America considering differences among communities, functional groups and species regarding environmental, spatial and connectivity‐related drivers of composition. We also examined phylogenetic and ecological correlates, such as incidence (i.e. frequency of occurrence across sites) and wing morphology, of the degree to which species respond to spatial and environmental drivers.LocationAtlantic Forest of Argentina, Brazil and Paraguay.TaxonPhyllostomid bats.MethodsData from the Atlantic Bats dataset were compiled for 39 species at 120 sites. Variation was partitioned into pure environmental, pure space, pure connectivity, joint and unaccounted variation fractions. Redundancy analyses or linear regression determined amount of variation in variation fractions that was accounted for by phylogeny or ecological characteristics of species.ResultsThe metacommunity of Atlantic Forest phyllostomid bats was significantly structured by environmental, space and connectivity characteristics. Animalivore, nectarivores and sanguinivore species composition was significantly related only to connectivity. Frugivores exhibited structure that was significantly related to all three kinds of characteristics (pure environmental, pure spatial and pure connectivity) and similar to that of the overall metacommunity. Species‐specific responses to environmental, spatial and connectivity drivers were variable but exhibited strong affinities related to phylogeny and functional group. As incidence of a species increased, variation in distribution and abundance was more related to environmental characteristics. There was no significant relationship between forearm length and magnitude of the connectivity variation partition.Main ConclusionsMetacommunity structure of bats in the Atlantic Forest is complex and includes variation across multiple scales of ecological organization. Structure is strongly associated with phylogenetic, functional and distributional characteristics of species, with these, in turn, related to responses to spatial and environmental gradients in the Atlantic Forest.
A new system to classify global climate zones based on plant physiology and using high temporal resolution climate data
Authors: Gardner Alexandra S. , Maclean Ilya M. D. , Gaston Kevin J. 
Published: July 2020

AbstractAimClimate classification systems (CCSs) can be used to predict how species’ distributions might be altered by climate change and to increase the reliability of these estimates is an important goal in biogeographical research. We produce an objective, global climate classification system (CCS) at high temporal resolution based on plant physiology as a robust way to predict how climate change may impact terrestrial biomes.LocationGlobalTaxonPlantaeMethodsWe construct ten climate variables that capture the physiological processes that determine plant distributions and use cluster analysis to present a new global CCS which accounts for variation in these aspects of climate. We use Kappa statistics to compare the distribution of climate zones in a five‐ and six‐cluster CCS constructed using the physiology variables to the popular Köppen‐Geiger and Köppen‐Trewartha CCSs, respectively, and find good correlation in both cases.ResultsOur CCS highlights ten climate zones for plants. We show that clustering of the physiologically relevant variables reproduces known, present‐day patterns of vegetation but also indicates important areas where zone assignment in our physiological CCSs is different to that of the Köppen systems.Main conclusionsThe existing Köppen CCSs do not entirely reflect the physiological processes that determine plant distributions. Predictions of climate‐driven changes in plant distributions may thus be unreliable in areas where zone assignment by clustering of physiologically relevant variables is different to that of the Köppen systems. Both the physiological relevance and temporal resolution of climate variables used to construct CCSs should be considered in order to predict reliably how climate change may alter plant distributions and to support an appropriate global response to conserve plant biodiversity for the future.
Catheter ablation of atrial tachycardias after mitral valve surgery: A systematic review and meta‐analysis
Authors: Marazzato Jacopo , Cappabianca Giangiuseppe , Angeli Fabio , Crippa Matteo , Golino Michele , Ferrarese Sandro , Beghi Cesare , De Ponti Roberto 
Published: July 2020

AbstractIntroductionData regarding catheter ablation (CA) of atrial tachycardias (ATs) occurring after mitral valve surgery (MVS) are scarce. The aim of this study was to assess the safety and efficacy of CA of ATs in this surgical population through a systematic review of the literature and meta‐analysis.MethodsA systematic search on PubMed/MEDLINE, EMBASE, and Web of Science was performed considering patients undergoing CA for ATs occurring after MVS. Periprocedural thromboembolic and hemorrhagic complications were assessed. The acute success and maintenance of sinus rhythm (SR) at a mid (<24 months) and long‐term follow‐up (FU) after CA were investigated along with the burden of arrhythmic recurrence at FU.ResultsFourteen studies for a total of 227 patients were considered. Three‐dimensional (3D) mapping systems were used in all studies. Only two major bleedings were recorded with a pooled estimate of periprocedural major complications of 0%. The acute success after CA was 95% with a clear improvement over time. Although maintenance of SR was 71% at a midterm FU, long‐term efficacy was as low as 47% due to an increased burden of atrial fibrillation (AF) recurrence despite multiple procedures/patient.ConclusionIn this meta‐analysis, CA of postsurgical ATs after MVS proved safe and effective but with still a significant burden of AF recurrence at more than 24 months of FU due to a progressive atrial substrate deterioration. The improvement of procedural success over time might suggest a learning curve in optimizing the use of 3D mapping systems.
Probability of sinus rhythm conversion and maintenance in cardiac resynchronization therapy patients with atrial fibrillation during 5‐year follow‐up
Authors: Ziegelhoeffer Tibor , Pecha Simon , Rahmani Rilind , Thaqi Nobel , Ackermann Xenia , Hakmi Samer , Choi Yeong‐Hoon , Burger Heiko 
Published: July 2020

AbstractIntroductionThere is a high prevalence of atrial fibrillation (AF) in patients with heart failure presented for cardiac resynchronization therapy (CRT). It remains unclear whether an atrial lead should be implanted in these patients. We, therefore, analyzed outcomes and course of rhythm in AF patients undergoing CRT implantation during long‐term follow‐up.Methods and ResultsBetween 2004 and 2018, 328 consecutive patients with a history of AF receiving CRT implantation were included in this study. 132 patients had preoperatively paroxysmal AF (px‐AF), while 70 and 126 patients had persistent AF (ps‐AF) and long‐standing persistent AF (lp‐AF), respectively. The outcome data were collected in our institutional database and analyzed retrospectively.Two hundred and seventy‐seven patients received an atrial lead at the time of implantation, nine during follow‐up. No major lead implantation‐associated complications were observed. In patients with px‐AF, sinus rhythm (SR) was present in 78.8% at admission, 95.5% (p < .001) at discharge, and 85.7% (p = .965) after 5 years. In ps‐AF patients SR was present in 28.6%, 91.4% (p < .001) and 69.7% (p < .001), while all lp‐AF patients showed AF at admission and had SR rate of 50.8% (p < .001) at discharge and 44.1% after 5 years (p < .001).ConclusionWe observed a high rate of conversion and long‐term persistence of SR in AF patients undergoing CRT implantation. Due to the low rate of lead implantation‐associated complications and the high successful SR conversion rates, we recommend the implantation of an atrial lead in CRT patients with AF.
Relationship between health‐related quality of life and blood pressure control in patients with uncontrolled hypertension
Authors: Lee Chan Joo , Park Woo Jung , Suh Jung‐Won , Choi Eue‐Keun , Jeon Dong Woon , Lim Sang‐Wook , Kim Dae‐Hyeok , Cha Kwang Soo , Lee Bong‐Ryeol , Kim Nam‐Ho , Kang Tae‐Soo , Ha Jong‐Won 
Published: July 2020

AbstractWe sought to investigate the psychosocial characteristics of patients with uncontrolled hypertension and examine factors that influence blood pressure (BP) control. A total of 1011 patients with uncontrolled hypertension were enrolled in 13 tertiary hospitals. Uncontrolled hypertension was defined as systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg despite on antihypertensive therapy. Socio‐demographics, anthropometrics, behavioral risk factors, medication pattern, adherence, and measures of health‐related quality of life (HRQoL; EuroQol 5D visual analog scale [EQ‐5D VAS]) were assessed at baseline and during follow‐up visits (3 and 6 months). Patients were divided into 2 groups based on BP control status at 6 months (controlled group [n = 532] vs uncontrolled group [n = 367]). There were no differences in clinical characteristics except the proportion of smokers and baseline BP between patients with controlled BP and uncontrolled BP. At 6 months, the adherence of antihypertensive medication did not differ between the groups but the proportion of combination therapy with ≥3 antihypertensives was significantly higher in patients with uncontrolled BP. EQ‐5D VAS at follow‐up was significantly lower in patients with uncontrolled BP despite similar baseline values. Multivariate logistic regression analysis revealed that EQ‐5D VAS at follow‐up significantly correlated with BP control. Patients with worse HRQoL had higher Charlson Comorbidity Index and higher proportion of taking ≥3 antihypertensives, but medication adherence was similar to those with better HRQoL. These findings suggest that along with pharmacologic intervention of hypertension, management of comorbid conditions or psychological support might be helpful for optimizing BP control in patients with uncontrolled hypertension.
LINC00160 mediated paclitaxel‐And doxorubicin‐resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ
Authors: Wu Huaiguo , Gu Juan , Zhou Daoping , Cheng Wei , Wang Yueping , Wang Qingping , Wang Xuedong 
Published: July 2020

AbstractChemoresistance represents a major challenge in breast cancer (BC) treatment. This study aimed to probe the roles of LINC00160 in paclitaxel‐ and doxorubicin‐resistant BC cells. Three pairs of BC and adjacent normal tissue were used for lncRNA microarray analysis. Paclitaxel‐resistant MCF‐7 (MCF‐7/Tax) and doxorubicin‐resistant BT474 (BT474/Dox) cells were generated by exposure of parental drug‐sensitive MCF‐7 or BT474 cells to gradient concentrations of drugs. Correlation between LINC00160 expression and clinical response to paclitaxel in BC patients was examined. Short interfering RNAs specifically targeting LINC00160 or TFF3 were designed to construct LINC00160‐ and TFF3‐depleted BC cells to discuss their effects on biological episodes of MCF‐7/Tax and BT474/Dox cells. Interactions among LINC00160, transcription factor C/EBPβ and TFF3 were identified. MCF‐7/Tax and BT474/Dox cells stable silencing of LINC00160 were transplanted into nude mice. Consequently, up‐regulated LINC00160 led to poor clinical response to paclitaxel in BC patients. LINC00160 knockdown reduced drug resistance in MCF‐7/Tax and BT474/Dox cells and reduced cell migration and invasion. LINC00160 recruited C/EBPβ into the promoter region of TFF3 and increased TFF3 expression. LINC00160‐depleted MCF‐7/Tax and BT474/Dox cells showed decreased tumour growth rates in nude mice. Overall, we identified a novel mechanism of LINC00160‐mediated chemoresistance via the C/EBPβ/TFF3 axis, highlighting the potential of LINC00160 for treating BC with chemoresistance.
SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population
Authors: Zhao Aonan , Li Yuanyuan , Niu Mengyue , Li Guanglu , Luo Ningdi , Zhou Liche , Kang Wenyan , Liu Jun 
Published: July 2020

AbstractNumerous single nucleotide polymorphisms (SNPs), which have been identified as susceptibility factors for Parkinson's disease (PD) as per genome‐wide association studies, have not been fully characterized for PD patients in China. This study aimed to replicate the relationship between 12 novel SNPs of 12 genes and PD risk in southern Chinese population. Twelve SNPs of 12 genes were detected in 231 PD patients and 249 controls, using the SNaPshot technique. Meta‐analysis was used to assess heterogeneity of effect sizes between this study and published data. The impact of SNPs on gene expression was investigated by analysing the SNP‐gene association in the expression quantitative trait loci (eQTL) data sets. rs8180209 of SNCA (allele model: P = .047, OR = 0.77; additive model: P = .047, OR = 0.77), rs2270968 of MCCC1 (dominant model: P = .024, OR = 1.52), rs7479949 of DLG2 (recessive model; P = .019, OR = 1.52), rs10748818 of GBF1 (additive model: P < .001, OR = 0.37), and rs4771268 of MBNL2 (recessive model: P = .003, OR = 0.48) were replicated to be significantly associated with the increased risk of PD. Noteworthy, a meta‐analysis of previous studies suggested rs8180209, rs2270968, rs7479949 and rs4771268 were in line with those of our cohort. Our study replicated five novel functional SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 could be associated with increased risk of PD in southern Chinese population.
Safely finishing a half marathon by an adult with type 1 diabetes using a commercially available hybrid closed‐loop system
Authors: van den Boom Louisa , Ziko Haris , Mader Julia K 
Published: July 2020

AbstractGlycemic targets are often difficult to achieve in people with type 1 diabetes, especially during exercise. Consequently, many people with type 1 diabetes avoid sports as a result of fear of hypoglycemia. Strenuous physical activity, such as a half marathon, imposes difficulties on people with type 1 diabetes. The first commercial hybrid closed‐loop (HCL) system with the potential to facilitate better diabetes management during exercise has recently been marketed. So far, no data on HCL performance during strenuous exercise have been published. A woman with well‐controlled type 1 diabetes participated in and safely finished a half marathon while undergoing HCL therapy. HCL could safely establish glycemic control without causing either hypo‐ or relevant hyperglycemia, and without the need for rescue carbohydrates while running. In the days after the half marathon, there was no change in glycemic control compared with the period before.
Length measurement accuracy of adaptive resolution imaging sonar and a predictive model to assess adult Atlantic salmon (Salmo salar) into two size categories with long‐range data in a river
Authors: Helminen Jani , Dauphin Guillaume J. R. , Linnansaari Tommi 
Published: July 2020

AbstractImaging sonars are used around the world for fish population monitoring. The accuracy of the length measurements has been reported in multiple studies for relatively short (<15 m) ranges and high image resolution. However, imaging sonars are often used at longer ranges (i.e., >15 m) where the images produced from sonar returns become less detailed. The accuracy of the length measurements from the Adaptive Resolution Imaging Sonar (ARIS) was tested by releasingn= 69 known‐sized adult Atlantic salmon (Salmo salar) directly into the sonar field at ranges between 15 and 29 m, and measuring their echoes manually by four users and semi‐automatically using a computer workflow in Echoview software. Overall, the length measurements were very variable: compared to true (fork) lengths, the mean of differences varied between −9.9 cm and 7.8 cm in the human‐generated datasets, and between −42.8 cm and −20 cm in the computer‐generated dataset. In addition, the length measurements in different datasets were only in poor or moderate agreement with each other (intraclass correlation <0.61). Contrary to our expectations, the distance from the transducer or the subjectively assessed echo quality did not have an effect on the measurement accuracy in most of the datasets and when it did, the effect was not systematic between the datasets. Therefore, a size class and length prediction model was implemented in a Bayesian framework to group salmon into two size categories: One‐Sea‐Winter (<63 cm) and Multi‐Sea‐Winter (≥63 cm) groups. The model correctly predicted the size category in 83% of the fish in the computer‐generated dataset and ranged from 68% to 74% in the human‐generated datasets. We conclude that fish length measurements derived from long‐range imaging sonar data should be used with caution, but post‐processing can improve the usefulness of the data for specific purposes, such as adult Atlantic salmon population monitoring.