bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Authors: Vanderbeke Lore , Mol Pierre Van , Herck Yannick van , Smet Frederik De , Humblet-Baron Stephanie , Martinod Kimberly , Antoranz Asier , Arijs Ingrid , Boeckx Bram , Bosisio Francesca , Casaer Michael , Dauwe Dieter , Wever Walter De , Dooms Christophe , Dreesen Erwin , Emmaneel Annelies , Filtjens Jessica , Gouwy Mieke , Gunst Jan , Hermans Greet , Jansen Sander , Lagrou Katrien , Liston Adrian , Lorent Natalie , Meersseman Philippe , Mercier Toine , Neyts Johan , Odent Julie , Panovska Dena , Penttila Pier Andree , Pollet Emily , Proost Paul , Qian Junbin , Quintelier Katrien , Raes Jeroen , Rex Steffen , Saeys Yvan , Sprooten Jenny , Tejpar Sabine , Testelmans Dries , Thevissen Karin , Buyten Tina Van , Vandenhaute Jessica , Gassen Sofie Van , Pereira Leydi Velasquez , Vos Robin , Weynand Birgit , Wilmer Alexander , Yserbyt Jonas , Garg Abhishek , Matthys Patrick , Wouters Carine , Lambrechts Diether , Wauters Els , Wauters Joost 
Published: October 2020

Abstract
Epidemiological and clinical reports have indicated that the host immune response to SARS-CoV-2, more so than viral factors, determines COVID-19 disease severity. To elucidate the immunopathology underlying COVID-19 severity, cytokine and multiplex immune profiling was performed in mild-moderate and critically-ill COVID-19 patients. Hypercytokinemia in COVID-19 differed from the IFN-γ-driven cytokine storm in macrophage activation syndrome, and was more pronounced in critical versus mild-moderate COVID-19. Systems modelling of cytokine levels followed by deep-immune profiling showed that classical monocytes drive this hyper-inflammatory phenotype and that a reduction in T-lymphocytes correlates with disease severity, with CD8+ cells being disproportionately affected. Expression of antigen presenting machinery was reduced in critical disease, while also neutrophils contributed to disease severity and local tissue damage by amplifying hypercytokinemia and neutrophil extracellular trap formation. We suggest a myeloid-driven immunopathology, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity.
The experiences of pregnant and lactating women during the earthquake emergency in Abruzzo: ten years later, what have we learned?
Authors: Giusti Angela , Marchetti Francesca , Zambri Francesca , Pro Elide , Brillo Eleonora , Colaceci Sofia 
Published: October 2020

Abstract
Background

Emergencies have a great impact on infant and young child feeding. Although the evidence, the recommended feeding practices are still not implemented in the emergency response, undermining infant and maternal health. The aim of this study was to explore the experiences of pregnant and lactating women during the earthquake emergency that occurred in L’Aquila on April 6, 2009.
Methods

The study design was qualitative descriptive. Data were collected by individual semi-structured interviews, investigating the mother’s experiences of pregnancy, childbirth, breastfeeding, infant formula or complementary feeding during the emergency and the post emergency phase. Data analysis was categorical and was performed by using N-Vivo software.
Results

Six women who were pregnant at the time of the earthquake were interviewed in January 2010. In addition to the essential needs of pregnant and lactating women, such as those related to the emergency shelters conditions, the main findings emerged from this study were: the reconfiguration of relationships and the central role of partners and family support; the need of spaces for sharing experiences and practices with other mothers; the lack of breastfeeding support after the hospital discharge; the inappropriate donations and distribution of Breast Milk Substitutes.
Conclusions

During and after L’Aquila earthquake, several aspects of infant and young child feeding did not comply with standard practices and recommendations. The response system appeared not always able to address the specific needs of pregnant and lactating women. It is urgent to develop management plans, policies and procedures and provide communication, sensitization, and training on infant and young child feeding at all levels and sectors of the emergency response.
Juvenile fibromyalgia: A call for diagnostic refinement, a case report
Authors: Peterson Elisha , Yao Caylynn , Sule Sangeeta D. , Finkel Julia C. 
Published: October 2020

Abstract
BackgroundFibromyalgia is a clinical syndrome consisting of widespread musculoskeletal tenderness and various somatic complaints including nonrestorative sleep, mood disorders such as anxiety or depression, abdominal pain, and/or headaches. There is a great deal of heterogeneity in its expression which leads to difficulty in identifying predisposing factors. A singular review of patients in an academic pediatric pain clinic reveal immune system dysfunction, mood disorders, infection, postural orthostatic tachycardia syndrome, complex regional pain syndrome, and hypermobility are premorbid conditions. It is unclear if these premorbid conditions confer a distinct fibromyalgia clinical phenotype that can provide insight into targeted therapies. Current diagnostic measures for fibromyalgia do not allow for this level of discrimination and are not validated in children.Case Presentation20 children who demonstrated widespread musculoskeletal pain, tenderness to pressure on exam and multiple somatic complaints were diagnosed with fibromyalgia. Average time from start of pain to diagnosis is 2 years. Over half the patients have psychopathology, a third have an immune system dysfunction related to autoimmunity or an infectious exposure, a third with orthostatic intolerance or postural orthostatic tachycardia syndrome, a quarter relating to hypermobility, and a quarter of the cohort with dysmenorrhea were pre or comorbid conditions. Effective therapeutic regimens among patients varied widely from responding to medical monotherapy to multimodal treatment. Trigger point injections worsened pain in one fibromyalgia patient but decreased pain in another. Patients with comorbid autoimmunity report appreciating a difference between a flare in their arthritis as opposed to a flare in their fibromyalgia. Such varying responses within the same clinical syndrome suggest distinct phenotypes within fibromyalgia which is difficult to distinguish using our current diagnostic tools.ConclusionThere is a need for clear diagnostic criteria for both the recognition of juvenile fibromyalgia and tools to distinguish phenotypes within fibromyalgia. Currently, the recognition of clinical symptoms renders it an often-overlooked neuropathic pain condition. This case series suggest there are different phenotypes within fibromyalgia. Some patients respond remarkably to serotonin norepinephrine reuptake inhibitors alone whereas others require multidisciplinary therapy. A diagnostic tool refined to capture these nuances can facilitate targeted treatment recommendations.
A comparison between laparoscopic and robotic-assisted laparoscopic pyeloplasty in patients with ureteropelvic junction obstruction
Authors: Lukkanawong Niwat , Honda Masashi , Teraoka Shogo , Kimura Yusuke , Yumioka Tetsuya , Iwamoto Hideto , Morizane Shuichi , Hikita Katsuya , Takenaka Atsushi 
Published: October 2020

Abstract
Background

The aim of this study is to compare the results of laparoscopic pyeloplasty and robotic-assisted laparoscopic pyeloplasty in patients with ureteropelvic junction obstruction.
Methods

Between March 2008 and May 2019, the patients who underwent retroperitoneal laparoscopic or robotic-assisted laparoscopic pyeloplasty in our institution were retrospectively reviewed.
Results

Thirteen patients underwent laparoscopically, and 12 patients underwent robotic surgery. The significant difference was found in median operative time between laparoscopic group (296 minutes) and robotic group (199 minutes) (P = 0.001). The median time for drain removal in laparoscopic group was longer than robotic group (3 vs 2 days, respectively, P = 0.029).
Conclusions

Laparoscopic and robotic-assisted laparoscopic pyeloplasty is safe and excellent success rates in patients with ureteropelvic junction obstruction. However, our experience study suggested that robotic surgery improves a total operative time, decreases drain removal time and less intraoperative blood loss than laparoscopic approach.
Venous Doppler Ultrasound in Critically Ill Covid-19 Patients: Game Changer in Anticoagulation Therapy
Authors: Alfageme Marta , Plaza Jorge González , Collado María Luisa , Méndez Santiago , Patiño Juan A. Gómez , Abadal Jose M. , Costero Rocío González , Fontanilla Teresa , Suárez Agustín García 
Published: October 2020

Abstract
BackgroundCOVID-19 infection has been associated with a high rate of thrombotic events, such as deep vein thrombosis (DVT) and acute pulmonary embolism (APE).MethodsThe purpose of our retrospective study was to evaluate the prevalence of asymptomatic DVT in lower limbs in critically ill COVID-19 patients (n=23) with severe respiratory failure and high levels of D-dimer by bedside Doppler ultrasound (DU).ResultsDVT was diagnosed in 14 cases (60.87%), 5 in proximal venous territory and 9 in infrapopliteal veins. CTPA was performed in 6 patients and all of them showed acute pulmonary embolism (APE) at segmental or subsegmental branches of pulmonary arteries. These patients (APE or DVT confirmed) were treated with therapeutic doses of anticoagulant therapy.ConclusionIn critically COVID 19 ill ICU patients with severe respiratory failure y elevated D-dimer the incidence of asymptomatic DVT is high. We propose that DU allows detection of DVT in asymptomatic patients, adding a factor that may balance the decision to fully anticoagulated these patients.
Association between ambient air pollution and in vitro fertilization pregnancy outcomes in Taiyuan: A retrospective study in a heavy polluted city in northern China
Authors: Xu Suming , Sun Chunqing , Bi Xingyu , Feng Dan , Zhang Lei , Wang Chunfang , Wang Yaoqin , Wu Xueqing 
Published: October 2020

Abstract
BackgroundGlobally, air pollution has a significant impact on human health. However, the effects of air pollution on pregnancy outcomes in patients undergoing in vitro fertilization (IVF) have not been fully understood. In this study, we analyzed the effects of air pollution on IVF pregnancy outcomes in Taiyuan, which is a heavy polluted city in northern China.Methods516 patients who underwent first fresh IVF cycle were enrolled in the retrospective study from January 1, 2015 to May 31, 2020. We collected medical record data from the electronic medical record system and daily average air pollution data from air quality monitoring station. Logistic regression was used to analyze the relationship between six atmospheric pollutants (PM2.5, PM10, O3, NO2, SO2, CO) and air quality index (AQI) and IVF pregnancy outcomes (biochemical pregnancy and clinical pregnancy) in different exposure periods. ResultsThe results indicated that exposure to NO2 was negatively associated with the odds of biochemical pregnancy and clinical pregnancy, whereas exposure to O3 presented positive association. Furthermore, we also found that AQI was negatively associated with IVF pregnancy outcomes. ConclusionsOur findings suggested that exposure to ambient air pollution during any period may have an impact on IVF pregnancy outcomes, and poor air quality is more likely to reduce clinical pregnancy rates.
Health-Related Quality of Life in Postpartum Recovery of Women who Practice Hypopressive Physical Activity. Randomized Clinical Trial.
Authors: Sánchez-García Juan Carlos , Aguilar-Cordero María josé , Montiel-Troya Maria , Marín-Jiménez Ana Eugenia , Mellado-García Elena , Rodríguez-Blanque Raquel 
Published: October 2020

Abstract
BackgroundPracticing physical exercise is a way of maintaining a healthy lifestyle and it has been demonstrated that it benefits and improves quality of life after labour. Aim To determine whether a workout programme using the Low-Pressure Fitness methodology has an impact on the Health-Related Quality of Life after labour.Material and MethodWe carried out a 12-weeks randomized clinical trial. It started at week 16 after labour and ended at postpartum week 28. Women followed a moderate intensity workout programme, using the Low-Pressure Fitness methodology in the treatment group, and we had a control group of sedentary women to perform a comparison. We used the SF-36v2 questionnaire at the postpartum weeks 16 and 28 to assess the Health-Related Quality of Life in women.ResultsWe found statistically significant differences (p<0.05) in general health components, vitality, emotional role, and mental health in the sample group of women under the Low-Pressure Fitness, who obtained a higher score. We found statistically significant differences in all aspects between the postpartum weeks 16 and 28. The interaction between time and group affect in general health components, vitality, emotional role and the score of mental component. In all of them the score is higher at week 28 and in the Low-Pressure Fitness group.ConclusionsPhysical exercise, following the Low-Pressure Fitness method, improves Health-Related Quality of Life after labour. We found that, when both the treatment and control groups are categorized by body-mass index, the Low-Pressure Fitness method was not determinant to improve the postpartum Health-Related Quality of Life. The trial is registered at the US National Institutes of Health (ClinicalTrials.gov), under the title “Physical Activity in Pregnancy and Postpartum Period, Effects on Women”. Number NCT02761967.
Controllable Vesicular Size and Shape in Polymerization-Induced Self-assembly Aided by Aromatic Interactions
Authors: Xu Xiao-Fei , Zhu Ren-Man , Pan Cai-Yuan , You Ye-Zi , Zhang Wen-Jian , Hong Chun-yan 
Published: October 2020

Abstract
The size and shape of polymeric vesicles have great impact on their physicochemical and biological properties. Polymerization-induced self-assembly (PISA) is an efficient method to fabricate vesicles. In most PISA-cases, the formation of vesicles is driven by the solvophobic interactions which are lack of versatility on finely structural regulation. Herein, controlling vesicular size and shape is realized in PISA aided by aromatic interactions. Aromatic interactions between the membrane-forming blocks contribute to the augments of membrane tension which lead to the formation of smaller vesicles (as small as 70 nm), but overly enhanced aromatic interactions result in vesicle fusion rather than size decreasing. When the membrane tension is dominated by aromatic interactions and meanwhile high enough to overcome the energetic barriers of fusion, the aromatic interactions drive vesicle fusion in a directional manner to form tubular structures. The precise regulation of vesicular size and shape in PISA would pave the way to fabricate vesicles for a series of size/shape-dependent applications.
Comparison Robotic versus laparoscopic partial nephrectomy for Complex Renal Tumors (with a RENAL nephrometry score≥7): a meta-analysis
Authors: Jiang Yu-Li , Xiao Xin , Peng Fu-Sheng , Shi Tian-Li , Huang Xiao-Hui , Zhou Jin-Biao , Li Peng 
Published: October 2020

Abstract
BackgroundTo compare the perioperative outcomes of Robotic partial nephrectomy (RPN) versus laparoscopic partial nephrectomy (LPN). MethodsWe searched PubMed, EMBASE and the Cochrane Central Register for studies from 2000 to 2020 to evaluate the perioperative outcomes RPN and LPN in patients with a RENALnephrometry score≥7. We used RevMan 5.2 to pool the data. ResultsSeven studies were acquired in our study. No significant differences were found in the estimated blood loss (WMD: WMD: 34.49, 95% CI -75.16-144.14, p=0.54), hospital stay (WMD: -0.59 95% CI -1.24–0.06, p=0.07), operating time (WMD: -22.45, 95%CI: -35.06 to-9.85, ), postive surgical margin (OR: 0.85, 95% CI 0.65–1.11, p =0.23) and transfusion (OR: 0.72, 95% CI 0.48–1.08, p =0.11).between the two groups. RPN get better outcomes in postoperative renal function (WMD: 3.32, 95% CI 0.73–5.91, p=0.01), warm ischenia time (WMD: -6.96, 95% CI -7.30–-6.62, p <0.0001), conversion( OR: 0.34, 95%CI: 0.17 to 0.66, p=0.002) and intraoperative complication (OR: 0.52, 95% CI 0.28–0.97, p=0.04).ConclusionRPN could get better perioerative clinical outcomes than LPN for treatment of Complex Renal Tumors( with a RENALnephrometry score≥7).
The Influence of Single Nucleotide Polymorphisms of NOD2 or CD14 on Susceptibility to Tuberculosis: A Systematic Review
Authors: Cubillos-Angulo Juan M , Fernandes Catarina D , Araújo Davi N , Carmo Cristinna A , Arriaga María B , Andrade Bruno Bezerril 
Published: October 2020

Abstract
Background: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with susceptibility or resistance to TB. Methods: A systematic review was performed on search platforms to examine the association between single nucleotide polymorphisms (SNP) and TB risk. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS) Results: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased TB risk. In contrast, the genotype CC was found to be protective against the disease. Furthermore, in two studies, rs2569191 SNP of the CD14, G allele was described to be significantly associated with increased TB risk. Four studies reported data uncovering the relationship between NOD2 SNPs and TB risk, with two of them reporting significant associations of rs1861759 and rs7194886 and higher TB risk in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower TB risk in African Americans. Conclusions: The CD14 rs2569190 and rs2569191 polymorphisms influence TB risk depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of TB, especially in persons with Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in TB susceptibility and physiopathology; such effect may be affected by ethnicity.Systematic review registration: CRD42020186523
High-Frequency Neuronavigated Repetitive Transcranial Magnetic Stimulation for Depression in Major Neurocognitive Disorders: A Randomized Controlled Trial
Authors: Lu Hanna , Lin Cuichan , Chan Sandra Sau Man , Ma Suk Ling , Mok Vincent Chung Tong , Shi Lin , Wang Defeng , Mak Arthur Dun-Ping , Lam Linda Chiu Wa 
Published: October 2020

Abstract
Background: We evaluated the safety and efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in major neurocognitive disorder (NCD) patients with depression.Methods: In this single blind, sham-controlled clinical trial, 58 patients of major NCD with clinically significant depressive symptoms (Cornell Depression Scale for Dementia, CSDD ≥ 7) were enrolled and randomly (1:1) assigned for a three-week treatment of either active rTMS (10 Hz, 120% motor threshold, 1500 pulses/session) or sham (placebo-controlled) rTMS treatment. Structural magnetic resonance imaging (MRI) scans were employed to localize the stimulation targets and guide the TMS coil during the treatment. Severity of depressive symptoms, global cognitive function and the serum brain-derived neurotrophic factor (BDNF) level were evaluated at baseline, post-intervention and 6-weeks and 12-weeks follow-ups. Results: Twenty-seven participants were randomized to receive active rTMS and 28 to receive sham rTMS. Both groups showed improvement in depressive symptoms and cognitive function after 3 weeks rTMS treatment. Logistic regression analysis revealed that older age (p = 0.016), higher baseline cognitive function (p = 0.041) and randomization group (p = 0.025) were associated with the remission of depression (Nagelkerke R2 = 0.42). Conclusions: A 3-week course of 10 Hz rTMS appears to be a safe intervention for bringing quicker remission of depression for neurocognitive disorder patients. Trial registration: ClinicalTrials.gov, ChiCTR-IOR-16008191. Registered on March 30, 2016.
Predictors of Maternal and Neonatal Complications in Patients With Severe Valve Heart Disease During Pregnancy
Authors: Hammami Rania , BELHADJ Mohamed Ali , Mejdoub Yosra , Bahloul Amine , Charfeddine Selma , Abid Leila , Kammoun Samir , Dammak Abdallah , Chaabene Kais 
Published: October 2020

Abstract
Background: The severe valve disease especially stenosis is a contraindication to conception according to WHO. This situation is still encountered in countries with a high rheumatic fever prevalence. The objective of this study was to determine the predictors of maternal cardiac, obstetric and neonatal complications. Methods: This is an observationnal study of all pregnant women with severe valvulopathy, delivered between 2010 and 2017. Results: We included 60 pregnancies in 54 women. Cardiac complications occurred in 37 patients (61%). In multivariate analysis, the predictors for these complications were parity (OR = 2.41, p = 0.023), revelation of valvulopathy by pregnancy (OR = 6.34, p = 0.025), severe mitral stenosis (OR = 6.84, p = 0.035) and systolic pulmonary arterial pressure (OR = 1.08, p = 0.01). Obstetrical complications were noted in 19 women (31.8%). The predictive factors for these complications were primiparity (OR = 5.22, p = 0.032), multiple valve disease (OR = 5.26, p = 0.028), systolic pulmonary arterial pressure (OR = 1.04, p = 0.04) and treatment with vitamin K antagonist (OR = 8.71, p = 0.04). Neonatal complications were noted in 39% of new-borns. The predictive factors for these complications were the occurrence of obstetric complications (OR = 15.48, p = 0.001) and the revelation of valvulopathy by pregnancy (OR = 6.95, p = 0.017). Conclusions: The revelation of valve disease by pregnancy is predictor of not only cardiac complication but also neonatal complications, thus valve disease screening during pre-conceptional counselling is crucial.