bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-threshold photoproduction of $$J/\psi $$ in two-gluon exchange model
Authors: Zeng Fancong , Wang Xiao-Yun , Zhang Li , Xie Ya-Ping , Wang Rong , Chen Xurong 
Published: November 2020

AbstractThe near-threshold photoproduction of $$J/\psi $$

J
/
ψ

is regarded as one golden process to unveil the nucleon mass structure, pentaquark state involving the charm quarks, and the poorly constrained gluon distribution of the nucleon at large x ($$>0.1$$

>
0.1

). In this paper, we present an analysis of the current experimental data under a two-gluon exchange model, which shows a good consistency. Using a parameterized function form with three free parameters, we have determined the nucleonic gluon distribution at the $$J/\psi $$

J
/
ψ

mass scale. Moreover, we predict the differential cross-section of the electroproduction of $$J/\psi $$

J
/
ψ

as a function of the invariant mass of the final hadrons W, at EicC, as a practical application of the model and the obtained gluon distribution. According to our estimation, hundreds of $$J/\psi $$

J
/
ψ

events can be detected per year on EicC near the threshold. Therefore, the relevant experimental measurements are suggested to be carried out on EicC.
Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank
Authors: Halford Jennifer L. , Weng Lu-Chen , Choi Seung Hoan , Jurgens Sean J. , Morrill Valerie N. , Khurshid Shaan , Trinquart Ludovic , Benjamin Emelia J. , Ellinor Patrick T. , Lubitz Steven A. 
Published: November 2020

Background:
Excess alcohol intake and inherited predisposition may increase risk of atrial fibrillation (AF). We assessed the association between alcohol intake, polygenic predisposition to AF, and incident AF in the UK Biobank, a prospective cohort study.

Methods:
In 376 776 UK Biobank participants enrolled between 2006 and 2010, we tested alcohol consumption (stratified by the Centers of Disease Control and Prevention acceptable range of ≤98 g/wk for women or ≤196 g/wk for men; and as a continuous variable) and an AF polygenic risk score for association with incident AF.

Results:
Among participants (47.5% male, mean age 56.9 years), 6293 developed AF during a median of 6.9 years of follow-up. Alcohol consumption was associated with AF (hazard ratio, 1.10 [95% CI, 1.05–1.16] for intake above an acceptable range; hazard ratio, 1.04 per 100 g/wk [95% CI, 1.02–1.06]). An AF polygenic risk score was associated with AF (hazard ratio, 1.38 per SD [95% CI, 1.35–1.41]). In models including both alcohol and the AF polygenic risk score, each remained associated with AF. The 5-year cumulative risk of AF for individuals with alcohol intake above an acceptable range and in the highest decile of polygenic risk was 2.33% (95% CI, 2.07–2.59), compared with 0.69% (95% CI, 0.58–0.80) for those with alcohol intake within an acceptable range and in the lowest decile of polygenic risk.

Conclusions:
Alcohol consumption is associated with increased risk of AF across a range of polygenic predisposition to AF and adds to inherited and clinical predisposition to increase AF susceptibility. Preventive efforts focused on minimizing alcohol intake may be broadly applicable.
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure
Authors: Abplanalp Wesley Tyler , Cremer Sebastian , John David , Hoffmann Jedrzej , Schuhmacher Bianca , Merten Maximillian , Rieger Michael A. , Vasa-Nicotera Mariuca , Zeiher Andreas M. , Dimmeler Stefanie 
Published: November 2020

Rationale:
Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence of cardiovascular disease and poor prognosis of patients with chronic heart failure (HF) and aortic stenosis. Although experimental studies suggest that DNMT3A clonal hematopoiesis–driver mutations may enhance inflammation, specific signatures of inflammatory cells in humans are missing.

Objective:
To define subsets of immune cells mediating inflammation in humans using single-cell RNA sequencing.

Methods and Results:

Transcriptomic profiles of peripheral blood mononuclear cells were analyzed in n=6 patients with HF harboring DNMT3A clonal hematopoiesis–driver mutations and n=4 patients with HF and no DNMT3A mutations by single-cell RNA sequencing. Monocytes of patients with HF carrying DNMT3A mutations demonstrated a significantly increased expression of inflammatory genes compared with monocytes derived from patients with HF without DNMT3A mutations. Among the specific upregulated genes were the prototypic inflammatory IL (interleukin)
IL1B (interleukin 1B), IL6, IL8
, the inflammasome
NLRP3
, and the macrophage inflammatory proteins
CCL3
and
CCL4
as well as resistin, which augments monocyte-endothelial adhesion. Silencing of DNMT3A in monocytes induced a paracrine proinflammatory activation and increased adhesion to endothelial cells. Furthermore, the classical monocyte subset of DNMT3A mutation carriers showed increased expression of T-cell stimulating immunoglobulin superfamily members
CD300LB
,
CD83
,
SIGLEC12
, as well as the CD2 ligand and cell adhesion molecule
CD58
, all of which may be involved in monocyte–T-cell interactions. DNMT3A mutation carriers were further characterized by increased expression of the T-cell alpha receptor constant chain and changes in T helper cell 1, T helper cell 2, T helper cell 17, CD8+ effector, CD4+ memory, and regulatory T-cell–specific signatures.

Conclusions:
This study demonstrates that circulating monocytes and T cells of patients with HF harboring clonal hematopoiesis–driver mutations in DNMT3A exhibit a highly inflamed transcriptome, which may contribute to the aggravation of chronic HF.
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm
Authors: Liu Cong-Lin , Liu Xin , Zhang Yuanyuan , Liu Jing , Yang Chongzhe , Luo Songyuan , Liu Tianxiao , Wang Yunzhe , Lindholt Jes S. , Diederichsen Axel , Rasmussen Lars M. , Dahl Marie , Sukhova Galina K. , Lu Guanyi , Upchurch Gilbert R. , Libby Peter , Guo Junli , Zhang Jinying , Shi Guo-Ping 
Published: November 2020

Rationale:
Blood eosinophil count and ECP (eosinophil cationic protein) associate with human cardiovascular diseases. Yet, whether eosinophils play a role in cardiovascular disease remains untested. The current study detected eosinophil accumulation in human and murine abdominal aortic aneurysm (AAA) lesions, suggesting eosinophil participation in this aortic disease.

Objective:
To test whether and how eosinophils affect AAA growth.

Methods and Results:

Population-based randomized clinically controlled screening trials revealed higher blood eosinophil count in 579 male patients with AAA than in 5063 non-AAA control (0.236±0.182 versus 0.211±0.154, 10
9
/L,
P
<0.001). Univariate (odds ratio, 1.381,
P
<0.001) and multivariate (odds ratio, 1.237,
P
=0.031) logistic regression analyses indicated that increased blood eosinophil count in patients with AAA served as an independent risk factor of human AAA. Immunostaining and immunoblot analyses detected eosinophil accumulation and eosinophil cationic protein expression in human and murine AAA lesions. Results showed that eosinophil deficiency exacerbated AAA growth with increased lesion inflammatory cell contents, matrix-degrading protease activity, angiogenesis, cell proliferation and apoptosis, and smooth muscle cell loss using angiotensin-II perfusion–induced AAA in
Apoe
−/−
and eosinophil-deficient
Apoe
−/−
ΔdblGATA mice. Eosinophil deficiency increased lesion chemokine expression, muted lesion expression of IL (interleukin) 4 and eosinophil-associated-ribonuclease-1 (mEar1 [mouse EOS-associated-ribonuclease-1], human ECP homolog), and slanted M1 macrophage polarization. In cultured macrophages and monocytes, eosinophil-derived IL4 and mEar1 polarized M2 macrophages, suppressed CD11b
+
Ly6C
hi
monocytes, and increased CD11b
+
Ly6C
lo
monocytes. mEar1 treatment or adoptive transfer of eosinophil from wild-type and
Il13
−/−
mice, but not eosinophil from
Il4
−/−
mice, blocked AAA growth in
Apoe
−/−
ΔdblGATA mice. Immunofluorescent staining and immunoblot analyses demonstrated a role for eosinophil IL4 and mEar1 in blocking NF-κB (nuclear factor-κB) activation in macrophages, smooth muscle cells, and endothelial cells.

Conclusions:
Eosinophils play a protective role in AAA by releasing IL4 and cationic proteins such as mEar1 to regulate macrophage and monocyte polarization and to block NF-κB activation in aortic inflammatory and vascular cells.
Normal and Abnormal Relationships of Pulmonary Artery to Wedge Pressure During Exercise
Authors: Bentley Robert F. , Barker Madeleine , Esfandiari Sam , Wright Stephen P. , Valle Felipe H. , Granton John T. , Mak Susanna 
Published: November 2020

Background
Resting right heart catheterization can assess both left heart filling and pulmonary artery (PA) pressures to identify and classify pulmonary hypertension. Although exercise may further elucidate hemodynamic abnormalities, current pulmonary hypertension classifications do not consider the expected interrelationship between PA and left heart filling pressures. This study explored the utility of this relationship to enhance the classification of exercise hemodynamic phenotypes in pulmonary hypertension.

Methods and Results
Data from 36 healthy individuals (55, 50–60 years, 50% male) and 85 consecutive patients (60, 49–71 years, 48% male) with dyspnea and/or suspected pulmonary hypertension of uncertain etiology were analyzed. Right heart catheterization was performed at rest and during semiupright submaximal cycling. To classify exercise phenotypes in patients, upper 95% CIs were identified from the healthy individuals for the change from rest to exercise in mean PA pressure over cardiac output (ΔmPAP/ΔCO ≤3.2 Wood units [WU]), pulmonary artery wedge pressure over CO (ΔPAWP/ΔCO ≤2 mm Hg/L per minute), and exercise PA pulse pressure over PAWP (PP/PAWP ≤2.5). Among patients with a ΔmPAP/ΔCO ≤3.2 WU, the majority (84%) demonstrated a ΔPAWP/ΔCO ≤2 mm Hg/L per minute, yet 23% demonstrated an exercise PP/PAWP >2.5. Among patients with a ΔmPAP/ΔCO >3.2 WU, 37% had an exercise PP/PAWP >2.5 split between ΔPAWP/ΔCO groups. Patients with normal hemodynamic classification declined from 52% at rest to 36% with exercise.

Conclusions
The addition of PP/PAWP to classify exercise hemodynamics uncovers previously unrecognized abnormal phenotypes within each ΔmPAP/ΔCO group. Our study refines abnormal exercise hemodynamic phenotypes based on an understanding of the interrelationship between PA and left heart filling pressures.
Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?
Authors: Mandalenakis Zacharias , Giang Kok Wai , Eriksson Peter , Liden Hans , Synnergren Mats , Wåhlander Håkan , Fedchenko Maria , Rosengren Annika , Dellborg Mikael 
Published: November 2020

Background
Despite advances in pediatric health care over recent decades, it is not clear whether survival in children with congenital heart disease (CHD) is still increasing.

Methods and Results
We identified all patients with CHD using nationwide Swedish health registries for 1980 to 2017. We examined the survival trends in children with CHD; we investigated the mortality risk in patients with CHD compared with matched controls without CHD from the general population using Cox proportional regression models and Kaplan–Meier survival analysis. Among 64 396 patients with CHD and 639 012 matched controls without CHD, 3845 (6.0%) and 2235 (0.3%) died, respectively. The mean study follow‐up (SD) was 11.4 (6.3) years in patients with CHD. The mortality risk was 17.7 (95% CI, 16.8–18.6) times higher in children with CHD compared with controls. The highest mortality risk was found during the first 4 years of life in patients with CHD (hazard ratio [HR], 19.6; 95% CI, 18.5–20.7). When stratified by lesion group, patients with non‐conotruncal defects had the highest risk (HR, 97.2; 95% CI, 80.4–117.4). Survival increased substantially according to birth decades, but with no improvement after the turn of the century where survivorship reached 97% in children with CHD born in 2010 to 2017.

Conclusions
Survival in children with CHD has increased substantially since the 1980s; however, no significant improvement has been observed this century. Currently, >97% of children with CHD can be expected to reach adulthood highlighting the need of life‐time management.
deus inludens … flenti similis (Οv. Met. 3.650-652)
Authors: Paschalis Sergios 
Published: November 2020

Abstract
Ovid’s fascination with Catullus’ Ariadne throughout his career has been the focus of considerable critical discussion and scholars have identified a plethora of Ovidian female figures imitating the speech of the Catullan heroine. This paper examines an overlooked incarnation of Catullus’ Ariadne in the episode of the Tyrrhenian sailors (Met. 3.577-700). Bacchus stages a reenactment of the tale of Theseus and Ariadne in Catullus 64.50-266 by impersonating the deserted princess and casting the Tyrrhenians in the role of the perfidious hero. The study suggests that the Ovidian god constitutes a unique instance of a male character appropriating the voice of Catullus’ female protagonist. Moreover, Bacchus’ epiphany inverts its Neoteric model: the Catullan ecphrastic account of the Dionysiac thiasos is represented as a vivid narrative teeming with motion and sound, while in the Metamorphoses the Bacchic miracles are figuratively depicted as a still and silent scene in an ecphrasis.
Bioethics Research Group and Beyond: Three Decades of Studies in Ethics and Political Philosophy
Authors: Holtug Nils , Lippert-Rasmussen Kasper , Ryberg Jesper , Sandøe Peter 
Published: November 2020

Abstract
The aim of this paper is to present some important contributions to ethics, value theory and political philosophy the former members of the Bioethics Research Group have made. The group was established at the University of Copenhagen in 1992 and was formally dissolved in 1997, but the members continued to work in ethics and political philosophy and set up research groups and centres at four Danish universities. Within four research themes, contributions made over the years are described. Research outputs of the group have, in various ways, served to bring studies of ethics and political philosophy originating in Denmark into the wider international research arena. Members of the group have increasingly included empirical approaches in their research and have thereby participated in the more general “empirical turn” in analytic philosophy. Some members of the group can also be said to have participated in a “pluralist turn”.
On the Structure of Instantaneous Radiative Forcing Kernels for Greenhouse Gases
Authors: Maycock Amanda C. , Smith Christopher J. , Rap Alexandru , Rutherford Owain 
Published: November 2020

AbstractThe Suite of Community Radiative Transfer Codes Based on Edwards and Slingo (SOCRATES) offline radiative transfer code is used to investigate the magnitude and structure of the instantaneous radiative forcing kernels (IRFKs) for five major greenhouse gases (GHGs; CO2, CH4, N2O, CFC-11, and O3). All gases produce IRFKs that peak in the tropical upper troposphere. In addition to differences in spectroscopic intensities and the position of absorption features relative to the peak of the Planck function for Earth’s temperature, the variation in current background concentration of gases substantially affects the IRFK magnitudes. When the background concentration of CO2 is reduced from parts per million to parts per trillion levels, the peak magnitude of the IRFK increases by a factor of 642. When all gases are set to parts per trillion concentrations in the troposphere, the peak IRFK magnitudes are 1.0, 3.0, 3.1, 58, and 75 W m−2 ppmv−1 (100 hPa)−1 for CH4, CO2, N2O, O3, and CFC-11, respectively. The altitude of the IRFK maximum also differs, with the maximum for CFC-11 and water vapor occurring above 100 hPa whereas the other gases peak near 150–200 hPa. Overlap with water vapor absorption decreases the magnitude of the IRFKs for all of the GHGs, particularly in the lower-to-middle troposphere, but it does not strongly affect the peak IRFK altitude. Cloud radiative effects reduce the magnitude of the IRFK for CO2 by around 10%–20% in the upper troposphere. The use of IRFKs to estimate instantaneous radiative forcing is found to be accurate for small-amplitude perturbations but becomes inaccurate for large-amplitude changes (e.g., a doubling) for gases with a higher atmospheric optical depth.
Exploring Convection-Allowing Model Evaluation Strategies for Severe Local Storms Using the Finite-Volume Cubed-Sphere (FV3) Model Core
Authors: Gallo Burkely T. , Wolff Jamie K. , Clark Adam J. , Jirak Israel , Blank Lindsay R. , Roberts Brett , Wang Yunheng , Zhang Chunxi , Xue Ming , Supinie Tim , Harris Lucas , Zhou Linjiong , Alexander Curtis 
Published: November 2020

AbstractVerification methods for convection-allowing models (CAMs) should consider the finescale spatial and temporal detail provided by CAMs, and including both neighborhood and object-based methods can account for displaced features that may still provide useful information. This work explores both contingency table–based verification techniques and object-based verification techniques as they relate to forecasts of severe convection. Two key fields in severe weather forecasting are investigated: updraft helicity (UH) and simulated composite reflectivity. UH is used to generate severe weather probabilities called surrogate severe fields, which have two tunable parameters: the UH threshold and the smoothing level. Probabilities computed using the UH threshold and smoothing level that give the best area under the receiver operating curve result in very high probabilities, while optimizing the parameters based on the Brier score reliability component results in much lower probabilities. Subjective ratings from participants in the 2018 NOAA Hazardous Weather Testbed Spring Forecasting Experiment (SFE) provide a complementary evaluation source. This work compares the verification methodologies in the context of three CAMs using the Finite-Volume Cubed-Sphere Dynamical Core (FV3), which will be the foundation of the U.S. Unified Forecast System (UFS). Three agencies ran FV3-based CAMs during the five-week 2018 SFE. These FV3-based CAMs are verified alongside a current operational CAM, the High-Resolution Rapid Refresh version 3 (HRRRv3). The HRRR is planned to eventually use the FV3 dynamical core as part of the UFS; as such evaluations relative to current HRRR configurations are imperative to maintaining high forecast quality and informing future implementation decisions.
ICAR '96 Conference Highlights - Part 2
Authors: Estey Chris , Grandsard Peter 
Published: November 2020

The International Conference on Automation, Robotics and Artificial Intelligence Applied to Analytical Chemistry and Laboratory Medicine has become the premier meeting dedicated to expanding the knowledge base in the rapidly evolving field of laboratory automation. This year was the fifth consecutive year for the International Conference, and we experienced impressive growth in registrations and exhibitions. The conference, held at the Sheraton Hotel and Marina in San Diego, California, featured 51 exhibitors, 14 sponsors, 54 oral presentations, 41 posters, and over 600 registrants and exhibitor associates. In the last issue of LAN, we covered the first day of scientific sessions which focused on artificial intelligence as well as the final session on novel technology. In this second part of a three-part article, we summarize Part 1 of the parallel scientific session of the conference.
FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis
Authors: Xu Peng , Scott Daniel C. , Xu Beisi , Yao Yu , Feng Ruopeng , Cheng Li , Mayberry Kalin , Wang Yong-Dong , Bi Wenjian , Palmer Lance E. , King Moeko T. , Wang Hong , Li Yuxin , Fan Yiping , Alpi Arno F. , Li Chunliang , Peng Junmin , Papizan James , Pruett-Miller Shondra M. , Spallek Ria , Bassermann Florian , Cheng Yong , Schulman Brenda A. , Weiss Mitchell J. 
Published: November 2020

Abstract
The histone mark H3K27me3 and its reader/writer polycomb repressive complex 2 (PRC2) mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms that regulate this activity are critical for hematopoietic development but are poorly understood. Here we show that the E3 ubiquitin ligase F-box only protein 11 (FBXO11) relieves PRC2-mediated repression during erythroid maturation by targeting its newly identified substrate bromo adjacent homology domain–containing 1 (BAHD1), an H3K27me3 reader that recruits transcriptional corepressors. Erythroblasts lacking FBXO11 are developmentally delayed, with reduced expression of maturation-associated genes, most of which harbor bivalent histone marks at their promoters. In FBXO11−/− erythroblasts, these gene promoters bind BAHD1 and fail to recruit the erythroid transcription factor GATA1. The BAHD1 complex interacts physically with PRC2, and depletion of either component restores FBXO11-deficient erythroid gene expression. Our studies identify BAHD1 as a novel effector of PRC2-mediated repression and reveal how a single E3 ubiquitin ligase eliminates PRC2 repression at many developmentally poised bivalent genes during erythropoiesis.
Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set
Authors: Chari Ajai , Samur Mehmet Kemal , Martinez-Lopez Joaquin , Cook Gordon , Biran Noa , Yong Kwee , Hungria Vania , Engelhardt Monika , Gay Francesca , García Feria Ana , Oliva Stefania , Oostvogels Rimke , Gozzetti Alessandro , Rosenbaum Cara , Kumar Shaji , Stadtmauer Edward A. , Einsele Hermann , Beksac Meral , Weisel Katja , Anderson Kenneth C. , Mateos María-Victoria , Moreau Philippe , San-Miguel Jesus , Munshi Nikhil C. , Avet-Loiseau Hervé 
Published: November 2020

Abstract
The primary cause of morbidity and mortality in patients with multiple myeloma (MM) is an infection. Therefore, there is great concern about susceptibility to the outcome of COVID-19–infected patients with MM. This retrospective study describes the baseline characteristics and outcome data of COVID-19 infection in 650 patients with plasma cell disorders, collected by the International Myeloma Society to understand the initial challenges faced by myeloma patients during the COVID-19 pandemic. Analyses were performed for hospitalized MM patients. Among hospitalized patients, the median age was 69 years, and nearly all patients (96%) had MM. Approximately 36% were recently diagnosed (2019-2020), and 54% of patients were receiving first-line therapy. Thirty-three percent of patients have died, with significant geographic variability, ranging from 27% to 57% of hospitalized patients. Univariate analysis identified age, International Staging System stage 3 (ISS3), high-risk disease, renal disease, suboptimal myeloma control (active or progressive disease), and 1 or more comorbidities as risk factors for higher rates of death. Neither history of transplant, including within a year of COVID-19 diagnosis, nor other anti-MM treatments were associated with outcomes. Multivariate analysis found that only age, high-risk MM, renal disease, and suboptimal MM control remained independent predictors of adverse outcome with COVID-19 infection. The management of MM in the era of COVID-19 requires careful consideration of patient- and disease-related factors to decrease the risk of acquiring COVID-19 infection, while not compromising disease control through appropriate MM treatment. This study provides initial data to develop recommendations for the management of MM patients with COVID-19 infection.