bluuebunny/crossref_metadata_2025_split huggingface dataset:
20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)
Authors: Taipale Heidi , Tanskanen Antti , Mehtälä Juha , Vattulainen Pia , Correll Christoph U. , Tiihonen Jari 
Published: January 2020

Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long‐term use is harmful for patients’ physical well‐being. However, there are no long‐term studies which have verified this view. This nationwide, register‐based cohort study aimed to assess the risk of hospitalization due to physical health problems, as a marker for severe physical morbidity, and the risk of all‐cause mortality, as well as of cardiovascular and suicidal death, associated with antipsychotic use in all patients treated for schizophrenia in inpatient care between 1972 and 2014 in Finland (N=62,250), with up to 20 years of follow‐up (median: 14.1 years). The use of antipsychotic drugs (i.e., use of any antipsychotic compared with non‐use) and the use of specific antipsychotics were investigated, and outcomes were somatic and cardiovascular hospitalization, and all‐cause, cardiovascular and suicide death. Hospitalization‐based outcomes were analyzed by a within‐individual design to eliminate selection bias, comparing use and non‐use periods in the same individual by stratified Cox model. Mortality outcomes were assessed by traditional between‐individual Cox multivariate models. The adjusted hazard ratios (aHRs) for any somatic hospitalization and cardiovascular hospitalization were 1.00 (95% CI: 0.98‐1.03) and 1.00 (95% CI: 0.92‐1.07) during use of any antipsychotic compared to non‐exposure periods within the same individual. The aHRs were 0.48 (95% CI: 0.46‐0.51) for all‐cause mortality, 0.62 (95% CI: 0.57‐0.67) for cardiovascular mortality, and 0.52 (95% CI: 0.43‐0.62) for suicide mortality during use vs. non‐use of any antipsychotic. The most beneficial mortality outcome was associated with use of clozapine in terms of all‐cause (aHR=0.39, 95% CI: 0.36‐0.43), cardiovascular (aHR=0.55, 95% CI: 0.47‐0.64) and suicide mortality (aHR=0.21, 95% CI: 0.15‐0.29). The cumulative mortality rates during maximum follow‐up of 20 years were 46.2% for no antipsychotic use, 25.7% for any antipsychotic use, and 15.6% for clozapine use. These data suggest that long‐term antipsychotic use does not increase severe physical morbidity leading to hospitalization, and is associated with substantially decreased mortality, especially among patients treated with clozapine.
Thermal phase transition in Yang-Mills matrix model
Authors: Bergner Georg , Bodendorfer Norbert , Hanada Masanori , Rinaldi Enrico , Schäfer Andreas , Vranas Pavlos 
Published: January 2020

Abstract
We study the bosonic matrix model obtained as the high-temperature limit of two-dimensional maximally supersymmetric SU(N) Yang-Mills theory. So far, no consensus about the order of the deconfinement transition in this theory has been reached and this hinders progress in understanding the nature of the black hole/black string topology change from the gauge/gravity duality perspective. On the one hand, previous works considered the deconfinement transition consistent with two transitions which are of second and third order. On the other hand, evidence for a first order transition was put forward more recently. We perform high-statistics lattice Monte Carlo simulations at large N and small lattice spacing to establish that the transition is really of first order. Our findings flag a warning that the required large-N and continuum limit might not have been reached in earlier publications, and that was the source of the discrepancy. Moreover, our detailed results confirm the existence of a new partially deconfined phase which describes non-uniform black strings via the gauge/gravity duality. This phase exhibits universal features already predicted in quantum field theory.
The holographic vortex lattice using the circular cell method
Authors: Tallarita Gianni , Auzzi Roberto 
Published: January 2020

Abstract
We investigate vortex lattice solutions in a holographic superconductor model in asymptotically AdS4 spacetime which includes the gravitational backreaction of the vortex. The circular cell approximation, which is known to give a good result for several physical quantities in the Ginzburg-Landau model, is used. The critical magnetic fields and the magnetization curve are computed. The vortex lattice profiles are compared to expectations from the Abrikosov solution in the regime nearby the upper critical magnetic field H2c for which superconductivity is lost.
Vector-like quarks with non-renormalizable interactions
Authors: Criado J. C. , Pérez-Victoria M. 
Published: January 2020

Abstract
We study the impact of the leading non-renormalizable terms in the effective field theory that describes general extensions of the Standard Model with vector-like quarks that can decay into Standard Model particles. Dropping the usual assumption of renormalizability has several phenomenological consequences for the production and decay of the heavy quarks and also for Higgs physics. The most dramatic effects, including those associated with a long lifetime, occur for vector-like quarks with non-standard quantum numbers.
Gapless and gapped holographic phonons
Authors: Amoretti Andrea , Areán Daniel , Goutéraux Blaise , Musso Daniele 
Published: January 2020

Abstract
We study a holographic model where translations are both spontaneously and explicitly broken, leading to the presence of (pseudo)-phonons in the spectrum. The weak explicit breaking is due to two independent mechanisms: a small source for the condensate itself and additional linearly space-dependent marginal operators. The low energy dynamics of the model is described by Wigner crystal hydrodynamics. In absence of a source for the condensate, the phonons remain gapless, but momentum is relaxed. Turning on a source for the condensate damps and pins the phonons. Finally, we verify that the universal relation between the phonon damping rate, mass and diffusivity reported in [1] continues to hold in this model for weak enough explicit breaking.
Teenagers, screens and social media: a narrative review of reviews and key studies
Authors: Orben Amy 
Published: January 2020

AbstractIntroductionIn light of growing concerns about an increasingly digital adolescence, the academic field investigating how digital technologies affect adolescents’ psychological well-being is growing rapidly. In the last years, much research has amassed, and this has been summarised in over 80 systematic reviews and meta-analyses.Materials and MethodsSystematic reviews, meta-analyses and key studies are reviewed to provide insights into the state of current research linking digital technology and social media use to well-being; possible future directions and improvements are discussed.ResultsWhen examining the reviews, it becomes evident that the research field is dominated by cross-sectional work that is generally of a low quality standard. While research has highlighted the importance of differentiating between different types of digital technology use many studies do not consider such necessary nuances. These limitations aside, the association between digital technology use, or social media use in particular, and psychological well-being is—on average—negative but very small. Furthermore, the direction of the link between digital technology use and well-being is still unclear: effects have been found to exist in both directions and there has been little work done to rule out potential confounders.ConclusionsReviewing the last decade of reviews in the area, it is evident that the research field needs to refocus on improving transparency, interpreting effect sizes and changing measurement. It also needs to show a greater appreciation for the individual differences that will inherently shape each adolescent’s reaction to digital technologies.
Late presentation of RPE65 retinopathy in three siblings
Authors: Magliyah Moustafa , Saifaldein Amjad Ameen , Schatz Patrik 
Published: January 2020

Abstract
Purpose
Gene therapy for RPE65 retinopathy has been recently approved. The purpose of this study was to assess retinal structure and function in 3 siblings presenting with late-stage RPE65 retinopathy and to assess the unmet need for such therapy in Saudi Arabia.

Methods
Search of the retinal dystrophy registry at King Khaled Eye Specialist Hospital and clinical examination including multimodal retinal imaging, full-field electroretinography (ERG), dark adapted full-field stimulus sensitivity thresholds, and molecular genetic testing in 3 patients.

Results
Nine (9) patients were identified with biallelic RPE65 mutations, corresponding to a prevalence rate of 9/187 = 5% among early onset retinal dystrophies. Of these, 3 siblings (2 male and 1 female) with RPE65 retinopathy were assessed in detail, because of an unusual, late presentation. They were all over 30 years old at the time of their most recent visits and had non-recordable ERGs. The 2 male siblings presented with poor vision and paracentral loss of the inner segment ellipsoid (ISe) and focal attenuation of the outer nuclear layer (ONL) in the macula. On the other hand, the female sibling presented with 20/100 vision with preserved foveal ISe and intact ONL throughout the macula and significantly lower light sensitivity thresholds compared to her male siblings. A homozygous missense p.Arg91Trp mutation in RPE65 was identified in all. All patients were eligible for gene therapy, demonstrating a central retinal thickness of more than 100 microns on repeated examinations.

Conclusions
RPE65 retinopathy seems to be relatively common on the Arabian peninsula, and in addition it may be underdiagnosed. To the best of our knowledge, this is the first detailed presentation, including multimodal retinal imaging and electrophysiological assessment, of such patients from this region. Patients with late presentation of RPE65 retinopathy may be eligible for gene therapy, in terms of remaining retinal function and structural preservation. The therapeutic window of such therapy remains to be determined.
Use of pre-industrial baselines to monitor anthropogenic enrichment of metals concentrations in recently deposited sediment of floodplain lakes in the Peace-Athabasca Delta (Alberta, Canada)
Authors: Owca Tanner J. , Kay Mitchell L. , Faber Jelle , Remmer Casey R. , Zabel Nelson , Wiklund Johan A. , Wolfe Brent B. , Hall Roland I. 
Published: January 2020

AbstractWell-designed monitoring approaches are needed to assess effects of industrial development on downstream aquatic environments and guide environmental stewardship. Here, we develop and apply a monitoring approach to detect potential enrichment of metals concentrations in surficial lake sediments of the Peace-Athabasca Delta (PAD), northern Alberta, Canada. Since the ecological integrity of the PAD is strongly tied to river floodwaters that replenish lakes in the delta, and the PAD is located downstream of the Alberta oil sands, concerns have been raised over the potential transport of industry-supplied metals to the PAD via the Athabasca River. Surface sediment samples were collected in September 2017 from 61 lakes across the delta, and again in July 2018 from 20 of the same lakes that had received river floodwaters 2 months earlier, to provide snapshots of metals concentrations (Be, Cd, Cr, Cu, Ni, Pb, V, and Zn) that have recently accumulated in these lakes. To assess for anthropogenic enrichment, surficial sediment metals concentrations were normalized to aluminum and compared to pre-industrial baseline (i.e., reference) metal-aluminum linear relations for the Athabasca and Peace sectors of the PAD developed from pre-1920 measurements in lake sediment cores. Numerical analysis demonstrates no marked enrichment of these metals concentrations above pre-1920 baselines despite strong ability (> 99% power) to detect enrichment of 10%. Measurements of river sediment collected by the Regional Aquatics- and Oil Sands-Monitoring Programs (RAMP/OSM) also did not exceed pre-1920 concentrations. Thus, results presented here show no evidence of substantial oil sands-derived metals enrichment of sediment supplied by the Athabasca River to lakes in the PAD and demonstrate the usefulness of these methods as a monitoring framework.
Stable and Accurate Filtering Procedures
Authors: Lundquist Tomas , Nordström Jan 
Published: January 2020

AbstractHigh frequency errors are always present in numerical simulations since no difference stencil is accurate in the vicinity of the $$\pi $$π-mode. To remove the defective high wave number information from the solution, artificial dissipation operators or filter operators may be applied. Since stability is our main concern, we are interested in schemes on summation-by-parts (SBP) form with weak imposition of boundary conditions. Artificial dissipation operators preserving the accuracy and energy stability of SBP schemes are available. However, for filtering procedures it was recently shown that stability problems may occur, even for originally energy stable (in the absence of filtering) SBP based schemes. More precisely, it was shown that even the sharpest possible energy bound becomes very weak as the number of filtrations grow. This suggest that successful filtering include a delicate balance between the need to remove high frequency oscillations (filter often) and the need to avoid possible growth (filter seldom). We will discuss this problem and propose a remedy.
Conscientious Objection: A Talmudic Paradigm Shift
Authors: Weiner Rabbi Jason 
Published: January 2020

AbstractConscientious objection remains a very heated topic with strong opinions arguing for and against its utilization in contemporary health care. This paper summarizes and analyzes various arguments in the bioethical literature, favoring and opposing conscientious objection, as well as some of the proposed solutions and compromises. I then present a paradigm shifting compromise approach that arises out of very recent Jewish bioethical thought that refocuses the discussion and can minimize the frequency with which conscientious objection is required.
Numerical methods for static shallow shells lying over an obstacle
Authors: Piersanti Paolo , Shen Xiaoqin 
Published: January 2020

AbstractIn this paper, a finite element analysis to approximate the solution of an obstacle problem for a static shallow shell confined in a half space is presented. To begin with, we establish, by relying on the properties of enriching operators, an estimate for the approximate bilinear form associated with the problem under consideration. Then, we conduct an error analysis and we prove the convergence of the proposed numerical scheme.
Hydrophysical properties of sandy clay contaminated by petroleum hydrocarbon
Authors: Hewelke Edyta , Gozdowski Dariusz 
Published: January 2020

AbstractThe aim of the presented research was to assess the changes in hydro-physical properties of sandy clay under the influence of petroleum hydrocarbon contamination. An understanding of these changes is fundamental in the right remedial actions and for further use of soil. Laboratory tests of inherently wettable sandy clay showed that the petroleum hydrocarbon induced potential soil water repellency (SWR) of extremely repellent class at the contamination of 18 g kg−1. The relationship between soil water potential (pF) and SWR determined by the WDPT test for given hydrocarbon contamination, i.e., 6, 12, 18, 30, 100 g kg−1, showed that the critical soil moisture value (CSMC) corresponds to the pF = 1.0 ÷ 1.5. Soil retention characteristic (pF) showed that an increase in hydrocarbon contamination from 0 to 100 g kg−1caused a reduction of total available water for plants from about 0.19 to 0.06 cm cm−3. At the same time, in the pF = 1.5 ÷ 2.0 range, intensive soil pore drainage was observed. Statistically, significant effect of hydrocarbon contamination and soil moisture potential on SWR was found. Soil hydrophobicity limits the addition of soil retention, because a significant part of the precipitation can be transformed by surface runoff. The carried out tests showed that at a hydrocarbon contamination of 30 g kg−1, total rainfall amount 14 mm with an intensity of 2 mm h−1was transformed into a surface drain in approx. 40%. The conducted studies demonstrate the adverse impact of hydrocarbon contamination on the soil’s hydro-physical properties. The soil water retention reduction and launching of the surface outflow, as a result of limiting the water penetration process resulting from SWR, change the agrohydrological conditions of the contaminated area. It can result as the imbalance of the flow of energy and matter in the ecosystem. The scenarios of environmental effects, among others, depend on the type of soil, the degree of its pollution, the type of ecosystem, and supporting activities undertaken by man. It should be taken into account that the increasing frequency of drought occurrence associated with climate change is conducive to the phenomenon of SWR regardless of the reasons for its occurrence.
Produktinnovationen und Produktmodifikationen in der Versicherungswirtschaft zwischen 2006 und 2017
Authors: Köhne Thomas , Melashenko Inna 
Published: January 2020

ZusammenfassungDie vorliegende empirische Untersuchung erfasst die Produktinnovationen und Produktmodifikationen im deutschen Versicherungsmarkt für Privatkunden; sie schließt an eine frühere Erhebung von 1996 bis 2005 an und untersucht die weitere Entwicklung der Produktneuerungen zwischen 2006 und 2017. Im theoretischen Teil werden begriffliche Grundlagen geklärt, die förderlichen und hinderlichen Rahmenbedingungen der Neuproduktentwicklung reflektiert sowie Arbeitshypothesen abgeleitet. Im empirischen Teil werden im Privatkundengeschäft 1457 Produktneuerungen identifiziert, davon sind 79 Produktinnovationen und 1378 Produktmodifikationen. Damit hat die Anzahl der Produktneuerungen im Vergleich zum früheren Zeitraum deutlich zugenommen und sich von durchschnittlich 65 auf 121 Produkte pro Jahr fast verdoppelt. Nach wie vor gibt es mit fast 95 % der Produktneuerungen erheblich mehr Produktmodifikationen als Produktinnovationen. Sowohl in der Lebens-, als auch in der Krankenversicherung wird nach wie vor ein Großteil der Produktneuerungen durch politisch-rechtliche Anstöße verursacht. Klassische Lebensversicherungsprodukte mit Garantiezins werden zunehmend von Alternativen ohne Garantien ersetzt. In der Schaden‑/Unfallversicherung sind Produktneuerungen demgegenüber oft Technologie- oder Risiko-induziert. Mithin hat das Produktneuerungsgebaren der Versicherer im deutschen Privatkundenmarkt in den zurückliegenden 12 Jahren – wenngleich auf moderatem Niveau – offensichtlich zugenommen, und das in allen Versicherungszweiggruppen.
Hierarchical N-Doped Porous Carbons for Zn–Air Batteries and Supercapacitors
Authors: Guo Beibei , Ma Ruguang , Li Zichuang , Guo Shaokui , Luo Jun , Yang Minghui , Liu Qian , Thomas Tiju , Wang Jiacheng 
Published: January 2020

AbstractNitrogen-doped carbon materials with a large specific surface area, high conductivity, and adjustable microstructures have many prospects for energy-related applications. This is especially true for N-doped nanocarbons used in the electrocatalytic oxygen reduction reaction (ORR) and supercapacitors. Here, we report a low-cost, environmentally friendly, large-scale mechanochemical method of preparing N-doped porous carbons (NPCs) with hierarchical micro-mesopores and a large surface area via ball-milling polymerization followed by pyrolysis. The optimized NPC prepared at 1000 °C (NPC-1000) offers excellent ORR activity with an onset potential (Eonset) and half-wave potential (E1/2) of 0.9 and 0.82 V, respectively (vs. a reversible hydrogen electrode), which are only approximately 30 mV lower than that of Pt/C. The rechargeable Zn–air battery assembled using NPC-1000 and the NiFe-layered double hydroxide as bifunctional ORR and oxygen evolution reaction electrodes offered superior cycling stability and comparable discharge performance to RuO2 and Pt/C. Moreover, the supercapacitor electrode equipped with NPC prepared at 800 °C exhibited a high specific capacity (431 F g−1 at 10 mV s−1), outstanding rate, performance, and excellent cycling stability in an aqueous 6-M KOH solution. This work demonstrates the potential of the mechanochemical preparation method of porous carbons, which are important for energy conversion and storage.
The Strategic Logic of Islamophobic Populism
Authors: Oztig Lacin Idil , Gurkan Turkan Ayda , Aydin Kenan 
Published: January 2020

AbstractIn Europe, the rise of populism is coupled with the rise of Islamophobia, vividly evident with exponential increases in votes for anti-Islam political parties in national elections. These parties portray Islam and Muslims as threats and maintain a position that Islam (as a religion and culture) is a threatening contrast to European values. By analysing Islamophobic discourses of the French National Front, Alternative for Germany and the Dutch Freedom Party, this article argues that Islamophobic populism targets not only Muslims, but also the incumbent leaders. By looking at the current dynamics of public opinion, this article explains how Islamophobic populism functions as an electoral strategy.
Evaluation of the relative contribution of meteorological and oceanic forces to the drift of ice islands offshore Newfoundland
Authors: Zeinali Torbati Reza , Turnbull Ian D. , Taylor Rocky S. , Mueller Derek 
Published: January 2020

AbstractOn 29 April 2015, four beacons were deployed onto an ice island in the Strait of Belle Isle to record positional data. The ice island later broke up into many fragments, four of which were tracked by the beacons. The relative influences of wind drag, current drag, Coriolis force, sea surface height gradient and sea-ice force on the drift of the tracked ice island fragments were analyzed. Using atmospheric and oceanic model outputs, the sea-ice force was calculated as the residual of the fragments' net forces and the sum of all other forces. This was compared against the force obtained through ice concentration-dependent relationships when sea ice was present. The sea-ice forces calculated from the residual approach and concentration-dependent relationships were significant only when sea ice was present at medium-high concentrations in the vicinity of the ice island fragments. The forces from ocean currents and sea surface tilt contributed the most to the drift of the ice island fragments. Wind, however, played a minimal role in the total force governing the drift of the four ice island fragments, and Coriolis force was significant when the fragments were drifting at higher speeds.