bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method of Calculating of Spiroid Gear Resource by Wear at Step Loading Mode
Authors: Zaitsev A V 
Published: April 2020

Abstract
The brief analysis of reasons of failure of mechanisms and drives of lifting, construction, and road-building machines based on engagement drives, and worm-gear class drives, represented by contact destructions of active surfaces of cog-wheel cogs resulting in malfunctions, breakages, failures, such as wear and furrows, was carried out. The need to create a method for calculating the wear of spiroids with regard of variable loading mode and time was substantiated. The method developed allows, with regard of real modes of operation of handling machinery, equipment and machines, determine the wear intensity values and calculate the spiroid gear drive resource with regard of duration of action of diving torque values in accordance with the set variable loading schedule for lifting, construction, and road-building machines under the wear intensity of the spiroid wheel cog on values of driving torque on the spiroid gear drive output shaft, obtained from experiments.
Designing an Information Security System in Smart Factories of the Industry 4.0
Authors: Zakoldaev D A , Shukalov A V , Zharinov I O , Zharinov O O 
Published: April 2020

Abstract
The problem of designing an information security system in smart factories of Industry 4.0 is investigated. Information security system is a company infrastructure component to provide the company information security. In the example of typical smart factory structure cyber and physical components are defined which are mostly susceptible to the malicious software components implementations. Such components could be components with their own means of calculations and engaged in the production technological operations. Smart factory information security risks can be explained with program and technical means for the operator to control the cyber and physical configuration remotely and other components of the production infrastructure into a single digital space of the company. Measures are proposed to increase the information security level of the Industry 4.0 smart factory based on technical, organization and program solutions.
Amino-acid conjugated protein–Au nanoclusters with tuneable fluorescence properties
Authors: Griep Mark H , Bedford Nicholas M 
Published: April 2020

AbstractAu-based protein nanoclusters (PNCs) represent an emerging class of fluorescence probes that are inherently biocompatible and combine the functionality of proteins and optical properties of Au nanoclusters. Here we report on a methodology to create conjugated Au PNCs using amino acid coupling strategies from a series of common laboratory proteins. We discover that the host protein and the specific conjugation chemistry has a profound influence on the resulting fluorescence properties. Synchrotron analyses showcase local Au NC aggeration upon PNC conjugation, which causes local environment changes to invoke differences in fluorscence properties. The observed aggeration does not give rise to plasmonic properties nor signifigant fluorescence quenching, strongly indicating the PNCs are still in a near-native cluster state. Our methodology and findings here could open new pathways for tuning PNC fluorescence properties in a rational fashion, having a potential impact in host of biomedical and sensing applications.
Impact of pain on reactive balance and falls in community-dwelling older adults: a prospective cohort study
Authors: Hirase Tatsuya , Okubo Yoshiro , Menant Jasmine , Lord Stephen R , Sturnieks Daina L 
Published: April 2020

Abstract

Background
pain is associated with increased postural sway and falls in older adults. However, the impact of pain on reactive balance induced by postural perturbations and how this might predispose older adults to falls is not known.

Objective
to investigate whether any pain, back/neck pain and lower limb pain are associated with poor reactive balance and prospective fall outcomes in older adults.

Design
12-month prospective cohort study.

Setting
community.

Subjects
242 community-dwelling older adults aged 70+ years.

Methods
participants completed a questionnaire on the presence of pain and underwent force-controlled waist-pull postural perturbations while standing. Force thresholds for stepping, step initiation time, step velocity and step length were quantified. Falls were monitored with monthly falls calendars for 12-months.

Results
participants with lower limb pain had significantly lower force thresholds for stepping. Those with any pain or pain in the back/neck had longer step initiation time, slower step velocity and shorter step length. The three pain measures (any pain, back/neck pain, lower limb pain) were significantly associated with multiple falls when adjusted for age, sex, body mass index, use of polypharmacy, strength and walking speed. In mediation analyses, there was a significant indirect effect of reactive balance for the relationship between back/neck pain and falls with fractures.

Conclusions
older people with pain have impaired reactive balance and an increased risk of falls. Reactive balance partially mediated the association between pain and fall-related fractures. Further research is required to confirm the findings of this study.
After Difference: A Meta-Comparative Study of Chinese Encounters with Foreign Comparative Law†
Authors: Seppänen Samuli 
Published: April 2020

Abstract
Do comparatists based in “radically different” legal systems experience “radical difference” and its side effects—self-doubt, suspicion of cultural bias, and feelings of inadequacy—when they research American and European law? Focusing on Chinese comparative law, this Article argues that Chinese legal scholars’ attitudes to difference (and similarity) are best explained as reflections of these scholars’ ideological projects. Describing American and European legal systems in terms of similarity rather than difference supports Chinese law reformers’ efforts to advance and defend Western-style legal institutions in China. Conversely, conservative socialist and neoconservative Chinese scholars who resist Western-style legal and political reforms seek to emphasize cultural, social, and political differences between China and the West. Comparative law therefore allows legal scholars to relate to foreign law in various, ideologically meaningful ways. Statements about difference and similarity—and attitudes towards understanding, in general—should be understood in the light of such ideological projects.
Intraspecific, ecotypic and home climate variation in photosynthetic traits of the widespread invasive grass Johnsongrass
Authors: Kelly Shannen , Fletcher Rebecca A , Barney Jacob N 
Published: April 2020

AbstractDespite their near ubiquity across global ecosystems, the underlying mechanisms contributing to the success of invasive plants remain largely unknown. In particular, ecophysiological traits, which are fundamental to plants’ performance and response to their environment, are poorly understood with respect to geographic and climate space. We evaluated photosynthetic trait variation among populations, ecotypes and home climates (i.e. the climates from the locations they were collected) of the widespread and expanding invader Johnsongrass (Sorghum halepense). We found that populations vary in the maximum net photosynthetic flux and the light-saturated net photosynthetic rate, and that agricultural and non-agricultural ecotypes vary in apparent quantum yield and water-use efficiency (WUE). We also found that populations from warmer home climates had lower dark respiration rates, light compensation points and WUEs. As Johnsongrass expands across the USA the abiotic and biotic environments are driving variation in its genetics, phenotypes and its underlying physiology. Our study demonstrates the importance of evaluating physiological traits in invasive plants, especially as they relate to home climates.
ExoBCD: a comprehensive database for exosomal biomarker discovery in breast cancer
Authors: Wang Xuanyi , Chai Zixuan , Pan Guizhi , Hao Youjin , Li Bo , Ye Ting , Li Yinghong , Long Fei , Xia Lixin , Liu Mingwei 
Published: April 2020

Abstract
Effective and safe implementation of precision oncology for breast cancer is a vital strategy to improve patient outcomes, which relies on the application of reliable biomarkers. As ‘liquid biopsy’ and novel resource for biomarkers, exosomes provide a promising avenue for the diagnosis and treatment of breast cancer. Although several exosome-related databases have been developed, there is still lacking of an integrated database for exosome-based biomarker discovery. To this end, a comprehensive database ExoBCD (https://exobcd.liumwei.org) was constructed with the combination of robust analysis of four high-throughput datasets, transcriptome validation of 1191 TCGA cases and manual mining of 950 studies. In ExoBCD, approximately 20 900 annotation entries were integrated from 25 external sources and 306 exosomal molecules (49 potential biomarkers and 257 biologically interesting molecules). The latter could be divided into 3 molecule types, including 121 mRNAs, 172 miRNAs and 13 lncRNAs. Thus, the well-linked information about molecular characters, experimental biology, gene expression patterns, overall survival, functional evidence, tumour stage and clinical use were fully integrated. As a data-driven and literature-based paradigm proposed of biomarker discovery, this study also demonstrated the corroborative analysis and identified 36 promising molecules, as well as the most promising prognostic biomarkers, IGF1R and FRS2. Taken together, ExoBCD is the first well-corroborated knowledge base for exosomal studies of breast cancer. It not only lays a foundation for subsequent studies but also strengthens the studies of probing molecular mechanisms, discovering biomarkers and developing meaningful clinical use.
miRactDB characterizes miRNA–gene relation switch between normal and cancer tissues across pan-cancer
Authors: Tan Hua , Kim Pora , Sun Peiqing , Zhou Xiaobo 
Published: April 2020

Abstract
It has been increasingly accepted that microRNA (miRNA) can both activate and suppress gene expression, directly or indirectly, under particular circumstances. Yet, a systematic study on the switch in their interaction pattern between activation and suppression and between normal and cancer conditions based on multi-omics evidences is not available. We built miRactDB, a database for miRNA–gene interaction, at https://ccsm.uth.edu/miRactDB, to provide a versatile resource and platform for annotation and interpretation of miRNA–gene relations. We conducted a comprehensive investigation on miRNA–gene interactions and their biological implications across tissue types in both tumour and normal conditions, based on TCGA, CCLE and GTEx databases. We particularly explored the genetic and epigenetic mechanisms potentially contributing to the positive correlation, including identification of miRNA binding sites in the gene coding sequence (CDS) and promoter regions of partner genes. Integrative analysis based on this resource revealed that top-ranked genes derived from TCGA tumour and adjacent normal samples share an overwhelming part of biological processes, which are quite different than those from CCLE and GTEx. The most active miRNAs predicted to target CDS and promoter regions are largely overlapped. These findings corroborate that adjacent normal tissues might have undergone significant molecular transformations towards oncogenesis before phenotypic and histological change; and there probably exists a small yet critical set of miRNAs that profoundly influence various cancer hallmark processes. miRactDB provides a unique resource for the cancer and genomics communities to screen, prioritize and rationalize their candidates of miRNA–gene interactions, in both normal and cancer scenarios.
Reduction of spontaneous cortical beta bursts in Parkinson’s disease is linked to symptom severity
Authors: Vinding Mikkel C , Tsitsi Panagiota , Waldthaler Josefine , Oostenveld Robert , Ingvar Martin , Svenningsson Per , Lundqvist Daniel 
Published: April 2020

Abstract
Parkinson’s disease is characterized by a gradual loss of dopaminergic neurons, which is associated with altered neuronal activity in the beta-band (13–30 Hz). Assessing beta-band activity typically involves transforming the time-series to get the power of the signal in the frequency domain. Such transformation assumes that the time-series can be reduced to a combination of steady-state sine- and cosine waves. However, recent studies have suggested that this approach masks relevant biophysical features in the beta-band—for example, that the beta-band exhibits transient bursts of high-amplitude activity. In an exploratory study, we used magnetoencephalography to record beta-band activity from the sensorimotor cortex, to characterize how spontaneous cortical beta bursts manifest in Parkinson’s patients on and off dopaminergic medication, and compare this to matched healthy controls. We extracted the time-course of beta-band activity from the sensorimotor cortex and characterized bursts in the signal. We then compared the burst rate, duration, inter-burst interval and peak amplitude between the Parkinson’s patients and healthy controls. Our results show that Parkinson’s patients off medication had a 5–17% lower beta bursts rate compared to healthy controls, while both the duration and the amplitude of the bursts were the same for healthy controls and medicated state of the Parkinson’s patients. These data thus support the view that beta bursts are fundamental underlying features of beta-band activity, and show that changes in cortical beta-band power in Parkinson’s disease can be explained—primarily by changes in the underlying burst rate. Importantly, our results also revealed a relationship between beta burst rate and motor symptom severity in Parkinson’s disease: a lower burst rate scaled with increased severity of bradykinesia and postural/kinetic tremor. Beta burst rate might thus serve as a neuromarker for Parkinson’s disease that can help in the assessment of symptom severity in Parkinson’s disease or in the evaluation of treatment effectiveness.
Sex Differences in Variability of Brain Structure Across the Lifespan
Authors: Forde Natalie J , Jeyachandra Jerrold , Joseph Michael , Jacobs Grace R , Dickie Erin , Satterthwaite Theodore D , Shinohara Russell T , Ameis Stephanie H , Voineskos Aristotle N 
Published: April 2020

AbstractSeveral brain disorders exhibit sex differences in onset, presentation, and prevalence. Increased understanding of the neurobiology of sex-based differences in variability across the lifespan can provide insight into both disease vulnerability and resilience. In n = 3069 participants, from 8 to 95 years of age, we found widespread greater variability in males compared with females in cortical surface area and global and subcortical volumes for discrete brain regions. In contrast, variance in cortical thickness was similar for males and females. These findings were supported by multivariate analysis accounting for structural covariance, and present and stable across the lifespan. Additionally, we examined variability among brain regions by sex. We found significant age-by-sex interactions across neuroimaging metrics, whereby in very early life males had reduced among-region variability compared with females, while in very late life this was reversed. Overall, our findings of greater regional variability, but less among-region variability in males in early life may aid our understanding of sex-based risk for neurodevelopmental disorders. In contrast, our findings in late life may provide a potential sex-based risk mechanism for dementia.
Iso-osmolar hyponatremia from polyethylene glycol
Authors: Tucker Bryan M , Pirkle James L , Stefi Erinda , Sheikh-Hamad David , DuBose Thomas 
Published: April 2020

Abstract
Understanding and applying pathophysiological concepts to patient care is an important skill for physicians in the clinical setting. Here, we present a case that demonstrates how the application of common physiological concepts relating to the widely accepted hyponatremia algorithm led to an accurate diagnosis of hyponatremia. This case documents iso-osmolar hyponatremia caused by orally administered polyethylene glycol absorption in the gastrointestinal tract. Herein, we discuss the workup and differential diagnosis for iso-osmolar hyponatremia in juxtaposition with the pathophysiological mechanisms unique to this case. We discuss these pathophysiological mechanisms based on the patients’ laboratory data and responses to therapeutic interventions.
Intrinsic cardiac elastography in patients with primary mitral regurgitation: predictive role after mitral valve repair
Authors: De Jesus Tais , Alashry Mahmoud M , Padang Ratnasari , Pislaru Sorin V , Nkomo Vuyisile T , Pellikka Patricia A , Pislaru Cristina 
Published: April 2020

Abstract

Aims
Chronic volume-overload can impair systolic and diastolic myocardial properties. We tested the hypothesis that Intrinsic Cardiac Elastography may detect alterations in passive myocardial elasticity in patients with chronic severe mitral regurgitation (MR) and predict worsening left ventricular (LV) function after mitral valve repair (MVr).

Methods and results
Comprehensive transthoracic echocardiography and cardiac elastography were performed in 80 patients with primary MR (prolapse and/or flail leaflets) of varying severity and compared with 40 normal subjects. In patients who underwent MVr (n = 51), elastography measurements were related to changes in left ventricular ejection fraction (LVEF) at short-term (3–4 days post-op) and mid-term (1 year) follow-up. Most patients were asymptomatic or mildly symptomatic and had preserved LVEF (&gt;60%). Intrinsic velocity propagation (iVP) of myocardial stretch, a direct measure of myocardial stiffness, was higher in patients with severe MR {median 2.0 [interquartile range (IQR) 1.5–2.2] m/s, range 1.1–3.4 m/s; n = 56} compared to normal subjects [median 1.7 (IQR 1.5–1.8) m/s; n = 40; P = 0.0005], but not in those with mild or moderate MR [median 1.7 (IQR 1.4–1.9) m/s; n = 24]. A higher iVP was associated with more severe LV volume-overload and LV and left atrial enlargement (P &lt; 0.05 for all). In patients undergoing MVr, a higher iVP independently predicted a larger drop in LVEF post-intervention (short-term, P = 0.001; 1 year, P = 0.007), incrementally to pre-operative LVEF (P &lt; 0.05).

Conclusion
Non-invasive measurements of myocardial stiffness were able to predict functional deterioration after MVr for chronic primary MR. Further studies should investigate the mechanisms and practical utility of this novel measurement.
Left ventricular reverse remodeling after successful subannular mitral valve repair in end-stage heart failure: a case report
Authors: Pausch Jonas , Sequeira Gross Tatiana , Reichenspurner Hermann , Girdauskas Evaldas 
Published: April 2020

Abstract

Background
Due to ongoing left ventricular (LV) remodeling and consecutive geometric displacement of both papillary muscles, end-stage heart failure is frequently associated with relevant functional mitral regurgitation (FMR) Type IIIb. Treatment strategies of FMR and their prognostic impact are still controversial.

Case summary
We present a case of an 80-year-old patient who suffered from recurrent symptoms of congestive heart failure due to dilated cardiomyopathy and concomitant severe FMR. To specifically address severe tethering of both mitral leaflets heart team decision was to perform minimally invasive mitral valve repair (MVR) including a subannular LV remodeling procedure, instead of an interventional edge-to-edge repair (MitraClip® procedure). In addition to mitral valve ring annuloplasty, standardized relocation of both papillary muscles was performed successfully, leading to a complete resolution of mitral leaflet tethering. There were no procedural complications and the patient was discharged with an excellent functional result without residual mitral regurgitation. Furthermore, after 12 and 24 months, he reported an increase of his functional exercise capacity and a remarkable reverse LV remodeling could be demonstrated.

Discussion
Novel subannular repair techniques, especially the relocation of both papillary muscles, specifically address severe leaflet tethering in FMR and have an obvious potential to improve long-term competence of MVR. Therefore, they could be considered as a viable therapeutic option even in elderly patients presenting with end-stage cardiomyopathy and severe leaflet tenting.
The antifungal pipeline: the need is established. Are there new compounds?
Authors: Li Dongmei , She Xiaodong , Calderone Richard 
Published: April 2020

ABSTRACTOur review summarizes and compares the temporal development (eras) of antifungal drug discovery as well as antibacterial ventures. The innovation gap that occurred in antibacterial discovery from 1960 to 2000 was likely due to tailoring of existing compounds to have better activity than predecessors. Antifungal discovery also faced innovation gaps. The semi-synthetic antibiotic era was followed closely by the resistance era and the heightened need for new compounds and targets. With the immense contribution of comparative genomics, antifungal targets became part of the discovery focus. These targets by definition are absolutely required to be fungal- or even lineage (clade) specific. Importantly, targets need to be essential for growth and/or have important roles in disease and pathogenesis. Two types of antifungals are discussed that are mostly in the FDA phase I–III clinical trials. New antifungals are either modified to increase bioavailability and stability for instance, or are new compounds that inhibit new targets. One of the important developments in incentivizing new antifungal discovery has been the prolific number of publications of global and country-specific incidence. International efforts that champion global antimicrobial drug discovery are discussed. Still, interventions are needed. The current pipeline of antifungals and alternatives to antifungals are discussed including vaccines.