bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of young (≤20 Myr) stellar populations in apparently quenched low-mass galaxies using red spectral line indices
Authors: de Lorenzo-Cáceres A , Vazdekis A , Falcón-Barroso J , Beasley M A 
Published: August 2020

ABSTRACT
We report on the detection of a small contribution (around and below 1 per cent in mass) from young stellar components with ages ≤20 Myr in low-mass galaxies purposely selected from the MaNGA survey to be already-quenched systems. Among the sample of 28 galaxies, 8 of them show signatures of having suffered a very recent burst of star formation. The detection has been done through the analysis of line-strength indices in the red spectral range [5700,8800] Å. The increasing contribution of red supergiants to this red regime is responsible for a deviation of the index measurements with respect to their position within the model grids in the standard spectral range [3600,5700] Å. We demonstrate that a combination of red indices, as well as a qualitative assessment of the mean luminosity-weighted underlying stellar population, is required in order to distinguish between a true superyoung population and other possible causes of this deviation, such as abundance ratio variations. Our result implies that many presumably quenched low-mass galaxies actually contain gas that is triggering some level of star formation. They have, therefore, either accreted external gas, internally recycled enough gas from stellar evolution to trigger new star formation, or they kept a gas reservoir after the harassment or stripping process that quenched them in the first place. Internal processes are favoured since we find no particular trends between our non-quenched galaxies and their environment, although more work is needed to fully discard an external influence.
Radio morphology of southern narrow-line Seyfert 1 galaxies with Very Large Array observations
Authors: Chen S , Järvelä E , Crepaldi L , Zhou M , Ciroi S , Berton M , Kharb P , Foschini L , Gu M , La Mura G , Vietri A 
Published: August 2020

ABSTRACT
We present the results of new radio observations carried out with the Karl G. Jansky Very Large Array C-configuration at 5.5 GHz for a sample of southern narrow-line Seyfert 1 galaxies (NLS1s). This work increases the number of known radio-detected NLS1s in the Southern hemisphere, and confirms that the radio emission of NLS1s is mainly concentrated in a central region at kpc-scale and only a few sources show diffuse emission. In radio-quiet NLS1s, the radio luminosity tends to be higher in steep-spectrum sources and be lower in flat-spectrum sources, which is opposite to radio-loud NLS1s. This may be because the radio emission of steep NLS1s is dominated by misaligned jets, active galactic nucleus driven outflows, or star formation superposing on a compact core. Instead the radio emission of flat NLS1s may be produced by a central core that has not yet developed radio jets and outflows. We discover new NLS1s harbouring kpc-scale radio jets and confirm that a powerful jet does not require a large-mass black hole to be generated. We also find sources dominated by star formation. These NLS1s could be new candidates in investigating the radio emission of different mechanisms.
The relationship between comet C/1853 G1 (Schweizer) and the γ-Aquilids and 52 Herculids meteor showers
Authors: Neslušan Luboš , Hajduková Mária 
Published: August 2020

ABSTRACT
We modelled several discrete parts of the meteoroid stream originating in comet C/1853 G1 (Schweizer). In a given model, the orbit of this parent comet was integrated in time backwards for a chosen period (10 000, 20 000, 40 000, or 80 000 yr) and, then, a cloud of 10 000 test particles was assumed to be ejected from the nucleus at the moment of the nearest comet’s perihelion passage. This set was subsequently integrated forward, up to the present. The showers related to the comet were predicted on the basis of the dynamical properties of the particles moving in orbits that approached close to the orbit of the Earth at the present. An uncertainty of the comet’s nominal orbit and its possible consequences on the predicted showers was estimated with a simultaneous following of a set of cloned orbits. We confirmed the proposed relationship between the comet and the γ-Aquilids, #531. Furthermore, our study yielded an indication that comet C/1853 G1 could also be the parent body of another shower, 52 Herculids, #605. We also found the real shower corresponding to the γ-Aquilids in three video data bases used. The 52 Herculids were identified in one of these data bases.
Implications of Canadian Hydrogen Intensity Mapping Experiment repeating fast radio bursts
Authors: Lu Wenbin , Piro Anthony L , Waxman Eli 
Published: August 2020

ABSTRACT
CHIME has now detected 18 repeating fast radio bursts (FRBs). We explore what can be learned about the energy distribution and activity level of the repeaters by fitting realistic FRB population models to the data. For a power-law energy distribution dN/dE ∝ E−γ for the repeating bursts, there is a critical index γcrit that controls whether the dispersion measure (DM, a proxy for source distance) distribution of repeaters is bottom or top-heavy. We find γcrit = 7/4 for Poisson wait-time distribution of repeaters in Euclidean space and further demonstrate how it is affected by temporal clustering of repetitions and cosmological effects. It is especially interesting that two of the CHIME repeaters (FRB 181017 and 190417) have large $\rm DM\sim 10^3\rm \, pc\, cm^{-3}$. These can be understood if: (i) the energy distribution is shallow $\gamma =1.7^{+0.3}_{-0.1}$ ($68{{\ \rm per\ cent}}$ confidence) or (ii) a small fraction of sources are extremely active. In the second scenario, these two high-DM sources should be repeating more than 100 times more frequently than FRB 121102 and the energy index is constrained to be $\gamma = 1.9^{+0.3}_{-0.2}$ ($68{{\ \rm per\ cent}}$ confidence). In either case, this γ is consistent with the energy dependence of the non-repeating ASKAP sample, which suggests that they are drawn from the same population. Finally, our model predicts how the CHIME repeating fraction should decrease with redshift and this can be compared with observations to infer the distribution of activity level in the whole population.
No missing photons for reionization: moderate ionizing photon escape fractions from the FIRE-2 simulations
Authors: Ma Xiangcheng , Quataert Eliot , Wetzel Andrew , Hopkins Philip F , Faucher-Giguère Claude-André , Kereš Dušan 
Published: August 2020

ABSTRACT
We present the escape fraction of hydrogen ionizing photons (fesc) from a sample of 34 high-resolution cosmological zoom-in simulations of galaxies at z ≥ 5 in the Feedback in Realistic Environments project, post-processed with a Monte Carlo radiative transfer code for ionizing radiation. Our sample consists of 8500 haloes in Mvir ∼ 108–$10^{12}\, M_{\odot }$ (M* ∼ 104–$10^{10}\, M_{\odot }$) at z = 5–12. We find the sample average 〈fesc〉increases with halo mass for Mvir ∼ 108–$10^{9.5}\, M_{\odot }$, becomes nearly constant for 109.5–$10^{11}\, M_{\odot }$, and decreases at ${\gtrsim}10^{11}\, M_{\odot }$. Equivalently, 〈fesc〉 increases with stellar mass up to $M_{\ast }\sim 10^8\, M_{\odot }$ and decreases at higher masses. Even applying single-star stellar population synthesis models, we find a moderate 〈fesc〉 ∼ 0.2 for galaxies at $M_{\ast }\sim 10^8\, M_{\odot }$. Nearly half of the escaped ionizing photons come from stars 1–3 Myr old and the rest from stars 3–10 Myr old. Binaries only have a modest effect, boosting 〈fesc〉 by ∼25–35 per cent and the number of escaped photons by 60–80 per cent. Most leaked ionizing photons are from vigorously star-forming regions that usually contain a feedback-driven kpc-scale superbubble surrounded by a dense shell. The shell is forming stars while accelerated, so new stars formed earlier in the shell are already inside the shell. Young stars in the bubble and near the edge of the shell can fully ionize some low-column-density paths pre-cleared by feedback, allowing a large fraction of their ionizing photons to escape. The decrease of 〈fesc〉 at the high-mass end is due to dust attenuation, while at the low-mass end, 〈fesc〉 decreases owing to inefficient star formation and hence feedback. At fixed mass, 〈fesc〉 tends to increase with redshift. Although the absolute 〈fesc〉does not fully converge with resolution in our simulations, the mass- and redshift-dependence of 〈fesc〉 is likely robust. Our simulations produce sufficient ionizing photons for cosmic reionization.
The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics
Authors: Wheeler David C , Stefansson Bergur V , Batiushin Mikhail , Bilchenko Oleksandr , Cherney David Z I , Chertow Glenn M , Douthat Walter , Dwyer Jamie P , Escudero Elizabeth , Pecoits-Filho Roberto , Furuland Hans , Górriz José Luis , Greene Tom , Haller Hermann , Hou Fan Fan , Kang Shin-Wook , Isidto Rey , Khullar Dinesh , Mark Patrick B , McMurray John J V , Kashihara Naoki , Nowicki Michal , Persson Frederik , Correa-Rotter Ricardo , Rossing Peter , Toto Robert D , Umanath Kausik , Van Bui Pham , Wittmann István , Lindberg Magnus , Sjöström C David , Langkilde Anna Maria , Heerspink Hiddo J L 
Published: August 2020

Abstract

Background
The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD; NCT03036150) trial was designed to assess the effect of the sodium–glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on kidney and cardiovascular events in participants with CKD with and without type 2 diabetes (T2D). This analysis reports the baseline characteristics of those recruited, comparing them with those enrolled in other trials.

Methods
In DAPA-CKD, 4304 participants with a urinary albumin:creatinine ratio (UACR) ≥200 mg/g and estimated glomerular filtration rate (eGFR) between 25 and 75 mL/min/1.73 m2 were randomized to dapagliflozin 10 mg once daily or placebo. Mean eGFR was 43.1 mL/min/1.73 m2 and median UACR was 949 mg/g (108 mg/mmol).

Results
Overall, 2906 participants (68%) had a diagnosis of T2D and of these, 396 had CKD ascribed to a cause other than diabetes. The most common causes of CKD after diabetes (n = 2510) were ischaemic/hypertensive nephropathy (n = 687) and chronic glomerulonephritis (n = 695), of which immunoglobulin A nephropathy (n = 270) was the most common. A total of 4174 participants (97%) were receiving an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, 1882 (43.7%) diuretics, 229 (5.3%) mineralocorticoid receptor antagonists and 122 (2.8%) glucagon-like peptide 1 receptor agonists. In contrast to the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), the DAPA-CKD trial enrolled participants with CKD due to diabetes and to causes other than diabetes. The mean eGFR of participants in the DAPA-CKD trial was 13.1 mL/min/1.73 m2 lower than in CREDENCE, similar to that in the Finerenone in Reducing Kidney Failure and Disease Progression in DKD (FIDELIO-DKD) trial and the Study Of diabetic Nephropathy with AtRasentan (SONAR).

Conclusions
Participants with a wide range of underlying kidney diseases receiving renin–angiotensin system blocking therapy have been enrolled in the DAPA-CKD trial. The trial will examine the efficacy and safety of dapagliflozin in participants with CKD Stages 2–4 and increased albuminuria, with and without T2D.
Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors
Authors: He Yuyu , Li Jie , Koga Tomoyuki , Ma Jun , Dhawan Sanjay , Suzuki Yuta , Furnari Frank , Prabhu Varun V , Allen Joshua E , Chen Clark C 
Published: August 2020

Abstract

Background
There are ongoing clinical trials exploring the efficacy of dopamine receptor D2 (DRD2) inhibition against glioblastomas, the most common primary brain tumor. Here we examine potential molecular determinants of this efficacy.

Methods
The Cancer Genome Atlas glioblastoma database and other published mRNA profiles were used to analyze the DRD2 and epidermal growth factor receptor (EGFR) expression pattern. In vitro and in vivo responses to DRD2 inhibitors were determined using patient-derived xenograft (PDX) glioblastoma models. Immunohistochemical studies were performed on clinically annotated glioblastoma samples derived from patients treated with ONC201.

Results
Analysis of clinical glioblastoma specimens derived from independent patient cohorts revealed an inverse correlation between EGFR and DRD2 mRNA expression, with implication that signaling mediated by these proteins shares overlapping functions. In independent panels of PDX glioblastoma lines, high EGFR expression was associated with poor in vitro and in vivo response to DRD2 inhibitors, including haloperidol and ONC201. Moreover, ectopic expression of a constitutively active EGFR, variant (v)III, suppressed glioblastoma sensitivity to ONC201. DRD2 expression positively correlated with expression of rate-limiting enzymes for dopamine synthesis as well as dopamine secretion, suggesting contribution of autocrine DRD2 signaling. Analysis of specimens from patients treated with ONC201 (n = 15) showed an inverse correlation between the intensity of EGFR staining and clinical response. The median overall survival for patients with high and low EGFR staining was 162 and 373 days, respectively (0.037).

Conclusions
High EGFR expression is a determinant of poor glioblastoma response to DRD2. This finding should inform future clinical trial designs.
Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas
Authors: Rossmeisl John H , Herpai Denise , Quigley Mindy , Cecere Thomas E , Robertson John L , D’Agostino Ralph B , Hinckley Jonathan , Tatter Stephen B , Dickinson Peter J , Debinski Waldemar 
Published: August 2020

AbstractBackgroundThe interleukin-13 receptor alpha 2 (IL13RA2) and ephrin type A receptor 2 (EPHA2) are attractive therapeutic targets, being expressed in ~90% of canine and human gliomas, and absent in normal brain. Clinical trials using an earlier generation IL-13 based cytotoxin showed encouraging clinical effects in human glioma, but met with technical barriers associated with the convection-enhanced delivery (CED) method. In this study, IL-13 mutant and ephrin A1 (EFNA1)–based bacterial cytotoxins targeted to IL13RA2 and EPHA2 receptors, respectively, were administered locoregionally by CED to dogs with intracranial gliomas to evaluate their safety and preliminary efficacy.MethodsIn this phase I, 3 + 3 dose escalation trial, cytotoxins were infused by CED in 17 dogs with gliomas expressing IL13RA2 or EPHA2 receptors. CED was performed using a shape-fitting therapeutic planning algorithm, reflux-preventing catheters, and real-time intraoperative MRI monitoring. The primary endpoint was to determine the maximum tolerated dose of the cytotoxic cocktail in dogs with gliomas.ResultsConsistent intratumoral delivery of the cytotoxic cocktail was achieved, with a median target coverage of 70% (range, 40–94%). Cytotoxins were well tolerated over a dose range of 0.012–1.278 μg/mL delivered to the target volume (median, 0.099 μg/mL), with no dose limiting toxicities observed. Objective tumor responses, up to 94% tumor volume reduction, were observed in 50% (8/16) of dogs, including at least one dog in each dosing cohort &gt;0.05 μg/mL.ConclusionsThis study provides preclinical data fundamental to the translation of this multireceptor targeted therapeutic approach to the human clinic.
Three Separate Clinical Entities of Infective Endocarditis—A Population-Based Study From Southern Finland 2013–2017
Authors: Halavaara Mika , Martelius Timi , Anttila Veli-Jukka , Järvinen Asko 
Published: August 2020

Abstract

Background
Health care–associated infective endocarditis (HAIE) and intravenous drug use–related IE (IDUIE) have emerged as major groups in infective endocarditis (IE). We studied their role and clinical picture in a population-based survey.

Methods
A population-based retrospective study including all adult patients diagnosed with definite or possible IE in Southern Finland in 2013–2017. IE episodes were classified according to the mode of acquisition into 3 groups: community-acquired IE (CAIE), HAIE, and IDUIE.

Results
Total of 313 episodes arising from 291 patients were included. Incidence of IE was 6.48/100 000 person-years. CAIE accounted for 38%, HAIE 31%, and IDUIE 31% of IE episodes. Patients in the IDUIE group were younger, and they more frequently had right-sided IE (56.7% vs 5.0%; P &lt; .001) and S. aureus as etiology (74.2% vs 17.6%; P &lt; .001) compared with the CAIE group. In-hospital (15.1% vs 9.3%; P = .200) and cumulative 1-year case fatality rates (18.5% vs 17.5%; P = .855) were similar in CAIE and IDUIE. Patients with HAIE had more comorbidities, prosthetic valve involvement (29.9% vs 10.9%; P = .001), enterococcal etiology (20.6% vs 5.9%; P = .002), and higher in-hospital (27.8% vs 15.1%; P = .024) and cumulative 1-year case fatality rates (43.3% vs 18.5%; P &lt; .001) than patients with CAIE. Staphylococcus aureus caused one-fifth of IE episodes in both groups.

Conclusions
Our study indicates that in areas where injection drug use is common IDUIE should be regarded as a major risk group for IE, along with HAIE, and not seen as part of CAIE. Three different risk groups, CAIE, HAIE, and IDUIE, with variable characteristics and outcome should be recognized in IE.
Changes in Waist Circumference in HIV-Infected Individuals Initiating a Raltegravir or Protease Inhibitor Regimen: Effects of Sex and Race
Authors: Bhagwat Priya , Ofotokun Ighovwerha , McComsey Grace A , Brown Todd T , Moser Carlee , Sugar Catherine A , Currier Judith S 
Published: August 2020

Abstract

Background
This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size.

Methods
We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 antiretroviral regimens: raltegravir (RAL) or the protease inhibitors (PIs) atazanavir/ritonavir (ATV/r) or darunavir/ritonavir (DRV/r), each in combination with tenofovir disoproxil fumarate/emtricitabine. Associations of treatment and baseline/demographic characteristics with 96-week WC change were assessed using repeated-measures models. Ordinal logistic regression was used to examine the associations of predictors with week 96 self-reported abdominal changes.

Results
The study population (n = 1809) was 76.0% male and predominantly black non-Hispanic (41.9%) and white non-Hispanic (34.1%). Mean baseline WC was 90.6 cm, with an average 96-week increase of 3.4 cm. WC increases were higher in the RAL arm compared with DRV/r (P = .0130). Females experienced greater increases in WC on RAL vs ATV/r than males (P = .0065). Similarly, a larger difference in WC change was found for RAL vs DRV/r for black vs nonblack individuals (P = .0043). A separate multivariable model found that in addition to the treatment regimen, higher baseline viral load and lower CD4+ were also associated with WC increases.

Conclusions
With antiretroviral therapy initiation, higher WC increases in the RAL arm compared with PIs were more pronounced in female and black participants, and a more advanced baseline HIV disease state was a strong predictor of larger abdominal increases. Understanding factors predisposing individuals to abdominal fat gain could inform health management after therapy initiation.
Negative pressure ventilation as a bridge to lung transplant
Authors: Martínez María D P , Alvarez Francisco G , Mallea Jorge M , Shah Sadia Z , Pham Si M , El-Sayed Ahmed Magdy M , Jacob Samuel , Janik Anthony B , Haddad Tarik , Erasmus David B , Narula Tathagat 
Published: August 2020

ABSTRACT
Recent years have witnessed evolution of lung allocation strategies to prioritize sicker recipients. In the pre-transplant period, this has translated into increased utilization of invasive extracorporeal or mechanical ventilatory support as a bridge to lung transplantation. The morbidity associated with these strategies warrants consideration to less invasive respiratory support modalities. Herein, we present a case highlighting successful bridge to lung transplantation with a relatively non-invasive negative pressure ventilator.
Hippopotamus bite morbidity: a report of 11 cases from Burundi
Authors: Haddara Moustafa M , Haberisoni Jean Berchmans , Trelles Miguel , Gohou Jean-Paul , Christella Kwizera , Dominguez Lynette , Ali Engy 
Published: August 2020

ABSTRACT
Hippopotamus is one of the most-loved animals in Africa, yet it is aggressive and dangerous. The co-existence of humans in close proximity to their natural habitat increases the probability of human injury. Hippopotamus attacks have long been recognized to cause serious injuries, but its magnitude and burden are still unknown. The medical literature is very scarce when it comes to documenting hippopotamus bite injuries and their outcomes. We present a cohort of 11 patients who suffered hippopotamus bite injuries in Burundi. To our knowledge, this is the largest case series reporting on the clinical presentation, injury patterns and surgical outcomes of hippopotamus bites. The results show a high incidence of wound infections, amputations and permanent disability among other complications. Hippopotamus-inflicted injuries should, therefore, be triaged as major trauma rather than just ‘mammalian bites’.
The balloon impasse sign in percutaneous transvenous mitral valvuloplasty
Authors: Simard Trevor , Thangarasa Tharshika , Di Santo Pietro , Labinaz Alisha , Hibbert Benjamin 
Published: August 2020

ABSTRACT
Percutaneous transvenous mitral valvuloplasty (PTMV) is an established therapy for rheumatic mitral stenosis (MS). While the Wilkins score standardizes the description of valve anatomy and predicts successful PTMV, echocardiographic assessment has some limitations. The ‘balloon impasse’ sign is the inability to cross a stenotic valve with a deflated Inoue balloon. This sign was described in the 1990s as an indicator of severe subvalvular thickening (regardless of the echocardiographic findings), portending an increased risk of severe mitral regurgitation (MR) post-PTMV. Despite its implications for management, it has been seldom reported. A 57-year-old woman with symptomatic, severe MS and a Wilkins score of 7 underwent PTMV. The ‘balloon impasse’ sign was observed when attempting to cross the stenotic valve. When the balloon was fully inflated, severe MR was noted, and the patient required mitral valve replacement. This case demonstrates the continued importance of the ‘balloon impasse’ sign and its implications for the therapeutic efficacy of PTMV.
Bilateral Mondor’s disease in chikungunya virus infection
Authors: Djebara Sarah , Henckaerts Liesbet , Vanbrabant Peter 
Published: August 2020

ABSTRACT
Chikungunya virus (CHIKV) is an arthropod-borne virus that is transmitted by Aedes mosquitoes, and its main features are high fever and (debilitating) arthritis. Infection with CHIKV, as well as other viruses, has been associated with hypercoagulable states and may be linked with the development of venous thrombosis. In fact, the development of deep venous thrombosis has been described in CHIKV infection. We present a case of superficial thrombophlebitis of the thoracic wall, known as Mondor’s disease, associated with CHIKV infection. To our knowledge, this probable association has never been described before.