bluuebunny/crossref_metadata_2025_split huggingface dataset:
A note on extremely primitive affine groups
Authors: Burness Timothy C. , Thomas Adam R. 
Published: October 2020

AbstractLet G be a finite primitive permutation group on a set $$\Omega $$
Ω
with non-trivial point stabilizer $$G_{\alpha }$$

G
α

. We say that G is extremely primitive if $$G_{\alpha }$$

G
α

acts primitively on each of its orbits in $$\Omega {\setminus } \{\alpha \}$$

Ω
\
{
α
}

. In earlier work, Mann, Praeger, and Seress have proved that every extremely primitive group is either almost simple or of affine type and they have classified the affine groups up to the possibility of at most finitely many exceptions. More recently, the almost simple extremely primitive groups have been completely determined. If one assumes Wall’s conjecture on the number of maximal subgroups of almost simple groups, then the results of Mann et al. show that it just remains to eliminate an explicit list of affine groups in order to complete the classification of the extremely primitive groups. Mann et al. have conjectured that none of these affine candidates are extremely primitive and our main result confirms this conjecture.
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
Authors: Mühleder Severin , Fernández-Chacón Macarena , Garcia-Gonzalez Irene , Benedito Rui 
Published: October 2020

AbstractTherapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The general view is that an increase in vascular growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. However, several recent studies showed that an increase in mitogenic stimuli can also lead to the arrest of angiogenesis. This is due to the existence of intrinsic signaling feedback loops and cell cycle checkpoints that work in synchrony to maintain a balance between endothelial proliferation and sprouting. This balance is tightly and effectively regulated during tissue growth and is often deregulated or impaired in disease. Most therapeutic strategies used so far to promote vascular growth simply increase mitogenic stimuli, without taking into account its deleterious effects on this balance and on vascular cells. Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. We also discuss alternative approaches to increase the effectiveness of pro-angiogenic therapies in cardiovascular regenerative medicine.
Maximal regularity for elliptic operators with second-order discontinuous coefficients
Authors: Metafune G. , Negro L. , Spina C. 
Published: October 2020

AbstractWe prove maximal regularity for parabolic problems associated to the second-order elliptic operator $$\begin{aligned} L =\Delta +(a-1)\sum _{i,j=1}^N\frac{x_ix_j}{|x|^2}D_{ij}+c\frac{x}{|x|^2}\cdot \nabla -b|x|^{-2} \end{aligned}$$

L
=
Δ
+

(
a
-
1
)

∑

i
,
j
=
1

N

x
i

x
j

|
x
|

2

D

ij

+
c

x

|
x
|

2

·
∇
-
b

|
x
|

-
2

with $$a>0$$

a
>
0

and $$b,\ c$$

b
,

c

real coefficients.
Color spectra algorithm of hyperspectral wood dyeing using particle swarm optimization
Authors: Wu Machao , Guan Xuemei , Li Wenfeng , Huang Qinglong 
Published: October 2020

AbstractTo improve the accuracy and practicality of the intelligent color-matching application of wood dyeing technology, Fraxinus mandshurica veneer was selected as the dyeing material. First, based on the Friele model and Stearns–Noechel model, the model parameters were cyclically assigned to calculate the optimal fixed parameter values and predictions. Then, particle swarm algorithm was used to optimize two algorithm models, the obtained reflectance curve was fit, and the color differences were calculated according to the human eye-based CIEDE2000 color difference evaluation standard formula. Last, the two formulas to predict the color difference and spectral reflectance were compared. First, the two optimization algorithms were compared according to the size of the fitted color difference value, and then, the most accurate optimization algorithm was selected. When the model parameters were fixed, the average fitted color difference was 0.8202. After optimizing the Friele model, the average fitted color difference was 0.7287, and after optimizing the Stearns–Noechel model, the average fitted color difference was 0.6482. It was concluded that the improved Stearns–Noechel model based on particle swarm method was more accurate than the Friele model for wood color matching.
MRI-visible perivascular spaces as an imaging biomarker in Fabry disease
Authors: Lyndon D. , Davagnanam I. , Wilson D. , Jichi F. , Merwick A. , Bolsover F. , Jager H. R. , Cipolotti L. , Wheeler-Kingshott C. , Hughes D. , Murphy E. , Lachmann R. , Werring D. J. 
Published: October 2020

Abstract
Introduction
Fabry disease (FD) is an X-linked lysosomal storage disorder resulting in vascular glycosphingolipid accumulation and increased stroke risk. MRI findings associated with FD include white matter hyperintensities (WMH) and cerebral microbleeds (CMBs), suggesting the presence of cerebral small vessel disease. MRI-visible perivascular spaces (PVS) are another promising marker of small vessel disease associated with impaired interstitial fluid drainage. We investigated the association of PVS severity and anatomical distribution with FD.

Patients and methods
We compared patients with genetically proven FD to healthy controls. PVS, WMH, lacunes and CMBs were rated on standardised sequences using validated criteria and scales, blinded to diagnosis. A trained observer (using a validated rating scale), quantified the total severity of PVS. We used logistic regression to investigate the association of severe PVS with FD.

Results
We included 33 FD patients (median age 44, 44.1% male) and 20 healthy controls (median age 33.5, 50% male). Adjusting for age and sex, FD was associated with more severe basal ganglia PVS (odds ratio (OR) 5.80, 95% CI 1.03–32.7) and higher total PVS score (OR 4.03, 95% CI 1.36–11.89). Compared with controls, participants with FD had: higher WMH volume (median 495.03 mm3 vs 0, p = 0.0008), more CMBs (21.21% vs none, p = 0.04), and a higher prevalence of lacunes (21.21% vs. 5%, p = 0.23).

Conclusions
PVS scores are more severe in FD than control subjects. Our findings have potential relevance for FD diagnosis and suggest that impaired interstitial fluid drainage might be a mechanism of white matter injury in FD.
Existence of continuous right inverses to linear mappings in finite-dimensional geometry
Authors: Kiselman Christer Oscar , Melin Erik 
Published: October 2020

AbstractA linear mapping of a compact convex subset of a finite-dimensional vector space always possesses a right inverse, but may lack a continuous right inverse, even if the set is smoothly bounded. Examples showing this are given, as well as conditions guaranteeing the existence of a continuous right inverse.
Texture and magnetic anisotropy of YBa2Cu3O7-x film on MgO substrate
Authors: Cornejo H. Sanchez , De Los Santos Valladares L. , Barnes C. H. W. , Moreno N. O. , Domínguez A. Bustamante 
Published: October 2020

AbstractThe texture and magnetic anisotropy of a YBa2Cu3O7-x (YBCO) film growth onto a MgO substrate are analyzed in order to understand the relation between them. X-ray diffraction shows the presence of the (00l) reflections from the YBCO layer with a grain’s fraction value 98%. Rocking Curves (RC) measurements reveal an out-of-plane texture with a full width at the half maximum of 0.81°, revealing a high uniaxial texture in the YBCO film. The temperature dependence of the susceptibility measurements obtained under many applied fields along Hext ||c-axis and Hext||ab-plane reveals strong relationship between the uniaxial texture and the magnetic anisotropy, confirming the high ordering of the CuO2 superconducting planes. In addition, the critical current density values are obtained from the hysteresis loops and compared to similar YBCO films with uniaxial and biaxial texture reported elsewhere.
Distress, Work Satisfaction, and Work Ability are Mediators of the Relation Between Psychosocial Working Conditions and Mental Health-Related Long-Term Sickness Absence
Authors: van Hoffen Marieke F. A. , Rijnhart Judith J. M. , Norder Giny , Labuschagne Lisanne J. E. , Twisk Jos W. R. 
Published: October 2020

AbstractPurpose This study investigated the effects of psychosocial working conditions on mental health-related long-term sickness absence and whether distress, work satisfaction, burnout, engagement, and work ability mediated the associations between psychosocial working conditions and mental health-related long-term sickness absence. Methods This cohort study included 53,833 non-sick listed workers who participated in occupational health surveys between 2010 and 2013. The effects of the individual psychosocial working conditions on mental long-term sickness absence were analyzed using univariable and multivariable logistic regression analyses. Mediation analyses were performed to examine the mediating role of distress, burnout, work satisfaction, engagement, and work ability between psychosocial working conditions and mental long-term sickness absence. The mediation analyses were performed using structural equation modeling. Results Role clarity, cognitive demands, emotional demands, work variety, learning opportunities, and co-worker support were related to mental health-related long-term sickness absence after adjustment for other working conditions. The relationship between emotional demands and mental health-related long-term sickness absence was the strongest, OR 1.304 (p < 0.001, 95% CI 1.135 to 1.498). The relation between psychosocial working conditions and mental health-related long-term sickness absence was mediated by distress, burnout, work satisfaction, engagement, and work ability. Distress was the most important mediator between psychosocial working conditions and mental health-related long-term sickness absence. Conclusions Psychosocial working conditions are related to mental health-related long-term sickness absence. After correction for other working conditions, the association between emotional demands and mental health-related long-term sickness absence was the strongest. Psychosocial working conditions are indirectly related to mental health-related long-term sickness absence through mediation by distress, work satisfaction, and work ability.
Chromatin-Level Differences Elucidate Potential Determinants of Contrasting Levels of Cold Sensitivity in Maize Lines
Authors: Jończyk Maciej , Sobkowiak Alicja , Trzcinska-Danielewicz Joanna , Sowiński Paweł 
Published: October 2020

AbstractMaize is a subtropical, cold-sensitive species. However, some varieties of this species have the potential to withstand long-term low temperatures, even at the seedling stage. The molecular basis of this phenomenon has not been determined. In a chromatin-level study, we compared the cold-stress reaction of seedlings of two maize inbred lines showing contrasting levels of cold sensitivity. The cold-tolerant line was selected based on field data and previous physiological and transcriptomic level studies. The first condition of gene expression—chromatin accessibility—was assessed by formaldehyde-aided isolation of regulatory elements method and DNA sequencing. Potentially expressed genes and cis-regulatory sequences open for interaction with transcription factors have been defined. The results of this study suggest that during cold stress, the tolerant maize line shifted resources from growth to defense. This shift was shown by potential hormone-level events—degradation of growth-promoting gibberellins and synthesis of jasmonic and abscisic acids. This finding is congruent with the xeromorphic morphology of seedlings of the cold-tolerant line and their ability to regrow when stress ceases. It is a common reaction of cold-tolerant maize lines. Moreover, in the cold-tolerant line, several genes from the low-temperature signaling pathways were potentially expressed. Additionally, numerous stress-response AP2/EREBP-binding cis-motifs were accessible in the cold-tolerant line. Differently in the cold-sensitive B73 line, MADS-binding cis-motifs were the most abundant. Development of the photosynthetic apparatus is crucial for the survival of maize seedlings at low temperature. Our results suggest efficient photosynthesis in seedlings of the cold-tolerant line, as was described earlier in physiological-level analyses.
Prosodic sensitivity and reading fluency of musicians and non-musicians
Authors: Obergfell Anja L. , Schmidt Barbara M. , Stenneken Prisca , Wittemann Sonja K. , Schabmann Alfred 
Published: October 2020

AbstractThis study investigates the effects of prosodic sensitivity on reading. Highly capable adult musicians (i.e., persons with potentially excellent prosodic skills) and non-musicians were compared in terms of prosodic sensitivity and reading. Furthermore, the study examines possible reciprocal effects of prosodic sensitivity and reading. Sixty native German-speaking university students, musicians (n = 30) and non-musicians (n = 30), completed three measures of prosodic sensitivity on the sentence level. In addition, word and nonword reading were tested. To check for possible reciprocal effects of prosodic sensitivity and reading, groups of musicians and non-musicians matched on the reading level as well as the prosodic sensitivity level were compared. The results showed that musicians outperformed non-musicians in two of the three prosodic sensitivity measures and both reading measures. Considering subgroup analysis this seems to indicate a non-reciprocal effect of prosodic sensitivity on reading. Moreover, when controlling for phonological awareness, prosodic sensitivity showed a unique effect on reading in the whole sample. Based on the results, we argue that good prosodic sensitivity can facilitate reading performance.
“Cerebral small vessel disease and other influential factors of cognitive impairment in the middle-aged: a long-term observational cohort PURE-MIND study in Poland”
Authors: Szcześniak Dorota , Rymaszewska Joanna , Zimny Anna , Sąsiadek Marek , Połtyn-Zaradna Katarzyna , Smith Eric E. , Zatońska Katarzyna , Zatoński Tomasz , Rangarajan Sumathy , Yusuf Salim , Szuba Andrzej 
Published: October 2020

AbstractA complex picture of factors influencing cognition is necessary to be drawn for a better understanding of the role of potentially modifiable factors in dementia. The aim was to assess the prevalence and determinants of cognitive impairment, including the role of cerebral small vessel disease (CSVD) in Polish middle-aged cohort. A comprehensive set of clinical (hypertension, coronary heart disease, diabetes mellitus, hyperlipidaemia, body mass index, smoking status, alcohol intake) and socio-demographic data was collected in the PURE study in years 2007–2016, which was the basis for detailed analysis of risk factors of cognitive impairments in years 2016–2018 in the PURE-MIND sub-study. Five hundred forty-seven subjects (age range 39–65, mean 56.2 ± 6.5) underwent neuropsychological assessment with Montreal Cognitive Assessment (MoCA), Trail Making Test (TMT) and Digit Symbol Substitution Test (DSST) followed by brain MRI. Mean MoCA score was 26.29 and 33% participants met criteria for mild cognitive impairment (MCI) (MoCA< 26). Seventy-three percent showed findings related to CSVD. Higher WMH burden and lacunar infarcts were associated with lower MoCA and DSST scores. Severe CSVD was associated with twofold incidence of MCI, and obesity increased its probability by 53% and hypertension by 37%. The likelihood of MCI was reduced in nonsmokers. One factor analysis showed the important role of lower level of education, older age, rural area of residence and hypertension. MCI and CSVD are highly prevalent in the middle-aged population in Poland. A greater importance should be given to potentially modifiable risk factors of dementia which are already present in mid-life.
Predictive maintenance as an internet of things enabled business model: A taxonomy
Authors: Passlick Jens , Dreyer Sonja , Olivotti Daniel , Grützner Lukas , Eilers Dennis , Breitner Michael H. 
Published: October 2020

AbstractPredictive maintenance (PdM) is an important application of the Internet of Things (IoT) discussed in many companies, especially in the manufacturing industry. PdM uses data, usually sensor data, to optimize maintenance activities. We develop a taxonomy to classify PdM business models that enables a comparison and analysis of such models. We use our taxonomy to classify the business models of 113 companies. Based on this classification, we identify six archetypes using cluster analysis and discuss the results. The “hardware development”, “analytics provider”, and “all-in-one” archetypes are the most frequently represented in the study sample. For cluster analysis, we use a visualization technique that involves an autoencoder. The results of our analysis will help practitioners assess their own business models and those of other companies. Business models can be better differentiated by considering the different levels of IoT architecture, which is also an important implication for further research.
Neonatal and carrier screening for rare diseases: how innovation challenges screening criteria worldwide
Authors: Cornel Martina C. , Rigter Tessel , Jansen Marleen E. , Henneman Lidewij 
Published: October 2020

AbstractScreening for rare diseases first began more than 50 years ago with neonatal bloodspot screening (NBS) for phenylketonuria, and carrier screening for Tay-Sachs disease, sickle cell anaemia and β-thalassaemia. NBS’s primary aim is health gain for children, while carrier screening enables autonomous reproductive choice. While screening can be beneficial, it also has the potential to cause harm and thus decisions are needed on whether a specific screening is worthwhile. These decisions are usually based on screening principles and criteria. Technological developments, both treatment driven and test driven, have led to expansions in neonatal screening and carrier screening. This article demonstrates how the dynamics and expansions in NBS and carrier screening have challenged four well-known screening criteria (treatment, test, target population and programme evaluation), and the decision-making based on them. We show that shifting perspectives on screening criteria for NBS as well as carrier screening lead to converging debates in these separate fields. For example, the child is traditionally considered to be the beneficiary in NBS, but the family and society can also benefit. Vice versa, carrier screening may be driven by disease prevention, rather than reproductive autonomy, raising cross-disciplinary questions regarding potential beneficiaries and which diseases to include. In addition, the stakeholders from these separate fields vary: Globally NBS is often governed as a public health programme while carrier screening is usually available via medical professionals. The article concludes with a call for an exchange of vision and knowledge among all stakeholders of both fields to attune the dynamics of screening.
Integrated mechanical earth model and quantitative risk assessment to successful drilling
Authors: Noohnejad Alireza , Ahangari Kaveh , Goshtasbi Kamran 
Published: October 2020

AbstractUse of vital geomechanical parameters for determination of safe mud pressure window is generally associated with high level of uncertainty primarily because of absence of sufficient calibration data including laboratory and field test information. The traditional deterministic wellbore stability analysis methodologies usually overlooked the uncertainty of these key parameters. This paper exhibits implementing a quantitative risk assessment technique on the basis of Monte-Carlo modeling to consider uncertainty from input data so as to make it possible to survey not just the likelihood of accomplishing a desired level of wellbore stability at a particular mud weight, but also the impacts of the uncertainty in each single parameter on the wellbore stability. This methodology was implemented to a case study. The most important parameters have been recognized using a sensitivity analysis approach in which the outcome of this QRA procedure suggests the mud weight window with likelihood of well drilling success which can elude the wellbore collapse and lost circulation events. This sort of stochastic approach to deal with anticipated safe mud weight window can guarantee stable wellbore with considerable cost viability associated with drilling success. The technique built up in this paper can give the scientific foundation for assessment of wellbore stability under complicated geological circumstances. It was likewise noted that based on sensitivity analysis, uniaxial compressive strength and maximum horizontal stress are the most effective parameter in estimation of mud weight window. This accentuates the significance of trustworthy determinations of these two parameters for safe drilling of the future wells in the field.
Methods and tools for environmental technologies risk evaluation: the principal guidelines—a review
Authors: Kowalska A. , Grobelak A. , Kacprzak M. , Lyng K.-A. 
Published: October 2020

AbstractThe commonly used and developing engineering environmental technologies do not remain neutral for an ecosystem. The deepening climate changes are generally considered as the effects of human activities. There is thus no doubt that any human interference in the environment should be comprehensively checked at the beginning for all its positive and negative aspects for the environment as well as society health. There are two different analytical tools useful in environmental management: life cycle assessment (LCA) and risk assessment (RA). The first follows the product from “from birth to the grave” summing the environmental impact at all stages of its “life” including such elements like producing, used electricity, transport and many others. LCA refers to quantification and classification of all effects at all life stages and provides direct and indirect possible environmental interactions. On the other hand, risk assessment focuses on linking stressors and its possibilities and severity. RA tools reveal environmental and human health impacts of strictly separated elements, providing insight as to which emission consists of an important threat. This paper is focused on summarizing two the most used methods and tools for supporting the decision making process in use of environmental engineering technologies. In this paper, the fundamental differences between LCA and RA and benefits from their use has been contained.