bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of patients’ satisfaction with different levels of hospitals in Beijing: why do patients prefer high-level hospitals?
Authors: Cui Chengsen , Zuo Xu , Wang Yujia , Song Haiyan , Shi Jingyu , Meng Kai 
Published: July 2020

Abstract
Background
To promote the integration of medical resources, Beijing has built medical alliances since 2012, but this reform has not changed the state of disordered medical treatment. Patients are still willing to go to high-level hospitals for medical treatment. What causes patients to prefer high-level hospitals? To explore the reasons behind this preference for high-level medical treatment among patients and to guide patients to make visits in an orderly manner, we conducted this study and compared patients’ satisfaction with hospitals of different levels in the context of medical resource integration.

Methods
This study conducted a questionnaire survey among 1250 patients who were selected in 18 medical alliances in Beijing from October to December 2016. The study type is a comparative study based on cross-sectional data. Patient satisfaction was the main outcome, and descriptive analysis, chi-square tests, nonparametric tests and binary logistic regression analysis were used. The level of statistical significance was set at p < 0.05.

Results
The overall satisfaction score of the medical alliances was 3.375, and the satisfaction scores of core hospitals and cooperative hospitals were 2.77 and 3.07, respectively. The overall patient satisfaction rate was 44.62%, and the satisfaction rates of core hospitals and cooperative hospitals were 34.34 and 50.43%, respectively. The type of hospital and understanding of medical alliance policy were the factors associated with patient satisfaction with the medical alliance.

Conclusions
The patients’ satisfaction with cooperative hospitals was higher than their satisfaction with core hospitals. Although the patients were more satisfied with the service attitude of the cooperative hospitals, they still preferred core hospitals due to their higher expectations for their medical treatment and greater trust in their medical technology. It is necessary to explore the establishment of closed medical alliances under the unified management of human and financial resources to enable medical alliances to become a community of common interests and provide integrated medical services for patients.
m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
Authors: Xie Jian-Wei , Huang Xiao-Bo , Chen Qi-Yue , Ma Yu-Bin , Zhao Ya-Jun , Liu Li-Chao , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Cao Long-Long , Lin Mi , Tu Ru-Hong , Zheng Chao-Hui , Huang Chang-Ming , Li Ping 
Published: July 2020

Abstract
Background
BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.

Methods
We obtained GC tissues and corresponding normal tissues from 8 patients and identified BATF2 as a downregulated gene via RNA-seq. qRT-PCR and western blotting were applied to examine BATF2 levels in normal and GC tissues. The prognostic value of BATF2 was elucidated using tissue microarray and IHC analyses in two independent GC cohorts. The functional roles and mechanistic insights of BATF2 in GC growth and metastasis were evaluated in vitro and in vivo.

Results
BATF2 expression was significantly decreased in GC tissues at both the mRNA and protein level. Multivariate Cox regression analysis revealed that BATF2 was an independent prognostic factor and effective predictor in patients with GC. Low BATF2 expression was remarkably associated with peritoneal recurrence after curative gastrectomy. Moreover, elevated BATF2 expression effectively suppressed GC growth and metastasis in vitro and in vivo. Mechanistically, BATF2 binds to p53 and enhances its protein stability, thereby inhibiting the phosphorylation of ERK. Tissue microarray results indicated that the prognostic value of BATF2 was dependent on ERK activity. In addition, the N6-methyladenosine (m6A) modification of BATF2 mRNA by METTL3 repressed its expression in GC.

Conclusions
Collectively, our findings indicate the pivotal role of BATF2 in GC and highlight the regulatory function of the METTL3/BATF2/p53/ERK axis in modulating GC progression, which provides potential prognostic and therapeutic targets for GC treatment.
Relationship of objectively measured physical activity and sedentary behaviour with health-related quality of life among breast cancer survivors
Authors: Nurnazahiah Ali , Shahril Mohd Razif , Nor Syamimi Zakarai , Ahmad Aryati , Sulaiman Suhaina , Lua Pei Lin 
Published: July 2020

Abstract
Background
Lack of physical activity throughout one’s lifetime has been associated with obesity and it is also an important risk factor of breast cancer. This study aimed to determine the relationship between objectively measured physical activity and sedentary behaviour with health-related quality of life (HRQoL) among breast cancer survivors in the East Coast region of Peninsular Malaysia.

Methods
A cross-sectional study involving 83 breast cancer survivors was carried out in two main government referral hospitals in the region. Participants wore the ActivPAL3™ microdevice physical activity monitor for seven consecutive days. The validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ–C30) and Breast Cancer Supplementary Measure (EORTC QLQ-BR23) were used to measure their HRQoL. Multiple linear regression analysis was conducted to determine the relationship between objectively measured physical activity and sedentary behaviour with HRQoL.

Results
Longer time spent on moderate to vigorous physical activity (MVPA) was significantly associated with an improvement of HRQoL (p = 0.039) whereas longer time spent on sedentary behaviour significantly reduced the functioning score (p = 0.005). In addition, prolonged sedentary bouts were also significantly associated with better body image that led to improved HRQoL (p = 0.013).

Conclusions
The study findings suggest that an increase in the time spent on MVPA was associated with improved HRQoL while sedentary behaviour was associated with poorer HRQoL among breast cancer survivors. Thus, it is essential to displace sedentary behaviour with MVPA to improve the quality of life of breast cancer survivors.
A literature-based approach for curating gene signatures in multifaceted diseases
Authors: Garand Mathieu , Kumar Manoj , Huang Susie Shih Yin , Al Khodor Souhaila 
Published: July 2020

Abstract
Background and aims
The task of identifying a representative and yet manageable target gene list for assessing the pathogenesis of complicated and multifaceted diseases is challenging. Using Inflammatory Bowel Disease (IBD) as an example, we conceived a bioinformatic approach to identify novel genes associated with the various disease subtypes, in combination with known clinical control genes.

Methods
From the available literature, we used Acumenta Literature LabTM (LitLab), network analyses, and LitLab Gene Retriever to assemble a gene pool that has a high likelihood of representing immunity-related subtype-specific signatures of IBD.

Results
We generated six relevant gene lists and 21 intersections that contain genes with unique literature associations to Crohn’s Disease (n = 60), Ulcerative Colitis (n = 17), and unclassified (n = 45) subtypes of IBD. From this gene pool, we then filtered and constructed, using network analysis, a final list of 142 genes that are the most representative of the disease and its subtypes.

Conclusions
In this paper, we present the bioinformatic construction of a gene panel that putatively contains subtype signatures of IBD, a multifactorial disease. These gene signatures will be tested as biomarkers to classify patients with IBD, which has been a clinically challenging task. Such approach to diagnose and monitor complicated disease pathogenesis is a stepping-stone towards personalized care.
Comparative surgical risk between type of trampoline (size and place) and type of patients (age and sex) in trampoline related injury: a systematic review and indirect meta-analysis
Authors: Muljadi Janisa Andrea , Chaijenkij Kornkit , Arirachakaran Alisara , Kongtharvonskul Jatupon 
Published: July 2020

AbstractBackgroundDespite its high risk of injury, many people are still favor trampolining. However, currently there is no consensus as to which type of trampoline and which type of participant is more likely to have a trampoline related injury that will require surgical management.MethodsThis systematic review and meta-analysis aims to assess and compare the factors that cause trampoline injuries requiring surgical treatment. These include the place of the trampoline (park versus home), size of the trampoline (full versus mini), the age of the participant (child versus adult) and the sex of the participant (male versus female). The clinical outcomes measured are surgical management after trampoline injury. This systematic review was conducted according to the PRISMA guidelines.ResultsRelevant studies that reported surgery after trampoline injury of either group were identified from Medline and Scopus from inception to May 14, 2019. Sixteen studies were included for the analysis of surgery after trampoline injury; a total of 4491 and 1121 patients were treated conservatively and surgically. The total surgery rate per patient was 31% (95% CI: 16, 46%) in all patients. The surgery rate was 0.3 (95% CI: 0.03, 0.58) and 0.06 (95% CI: 0.04, 0.09) in the full and mini size trampoline groups. There were 0.36 (95% CI: 0.06, 0.67) and 0.11 (95% CI: 0.0, 0.22) in the park and home trampoline groups. The surgery rates were 0.33 (95% CI: 0.14, 0.53), 0.24 (95% CI: 0.07, 0.11), 0.49 (95% CI: 0.47, 0.51) and 0.38 (95% CI: 0.22, 0.53) in children, adults, females and males respectively. Indirect meta-analysis shows that full size trampolines provided a 6.0 times higher risk of surgery (95% CI: 3.7, 9.7) when compared to mini size trampolines. Park trampolines had a higher risk of surgery of 2.17 (95% CI: 1.70, 2.78) when compared to home trampolines. In terms of age and sex of participants, there value was significantly higher at 1.65 (95% CI: 1.35, 2.01) and 1.54 (95% CI: 1.36, 1.74) in children compared to adults and females compared to males. From all the statistical data we summarized that the full size trampoline injuries have a 6 times higher risk of requiring surgery when compared to mini size trampoline injuries. Park trampoline use carries a 2 times higher risk of requiring surgery when compared to home trampoline use. In terms of age and sex of the participant, there is a 1.5 times significantly higher risk of injury in children compared to adults, and females when compared to males.ConclusionIn trampoline related injuries, full size, park trampoline, children and females had higher surgery rates when compared to mini size, home trampoline, adult and male majority in indirect meta-analysis methods.
A self-adaptive inertial subgradient extragradient method for pseudomonotone equilibrium and common fixed point problems
Authors: Jolaoso Lateef Olakunle , Aphane Maggie 
Published: July 2020

AbstractIn this paper, we introduce a self-adaptive inertial subgradient extragradient method for solving pseudomonotone equilibrium problem and common fixed point problem in real Hilbert spaces. The algorithm consists of an inertial extrapolation process for speeding the rate of its convergence, a monotone nonincreasing stepsize rule, and a viscosity approximation method which guaranteed its strong convergence. More so, a strong convergence theorem is proved for the sequence generated by the algorithm under some mild conditions and without prior knowledge of the Lipschitz-like constants of the equilibrium bifunction. We further provide some numerical examples to illustrate the performance and accuracy of our method.
Unilateral sagittal split osteotomy: effect on mandibular symmetry in the treatment of class III with laterognathia
Authors: Abou Chebel Naji , Saadeh Maria , Haddad Ramzi 
Published: July 2020

Abstract
The bilateral sagittal split osteotomy is considered the standard surgery to correct facial asymmetries. More recently, unilateral sagittal split osteotomy (USSO) was used to treat such malocclusions.

Aim
To assess facial symmetry following USSO in the treatment of class III laterognathia.

Methods
Frontal facial photographs of four groups of patients were assessed: (1) pre-surgical group (n = 30) with skeletal asymmetry, (2) postsurgical group assessing patients of the first group 2 years after USSO, (3) control group (n = 30) of patients judged to have harmonious facial norms, and (4) mirrored group (n = 30) in which the control photographs were altered by duplicating the right half side of the face to replace the left half, thus creating perfectly symmetrical faces. All 120 photographs were distributed to 40 expert orthodontists to evaluate and score facial symmetry using the visual analog scale. Skin sensitivity and temporomandibular joint (TMJ) disorders were also assessed clinically pre and postsurgically.

Results
Statistically significant differences were observed between the pre-surgical group and each of the postsurgical and control groups (p < 0.001). The control and postsurgical groups received similar scores of symmetry (p = 0.774). The mirrored group received statistically significantly higher symmetry scores than either of the control or the postsurgical groups (p < 0.001). A reduction in TMJ disorders was noted after USSO and all patients reported normal skin sensation 2 years post-surgery.

Conclusion
When indicated, USSO is a dependable and practical surgical approach to correct facial asymmetries associated with class III malocclusion.
Predicting stand age in managed forests using National Forest Inventory field data and airborne laser scanning
Authors: Maltamo Matti , Kinnunen Hermanni , Kangas Annika , Korhonen Lauri 
Published: July 2020

Abstract
Background
The aim of this study was to construct a nationwide stand age model by using National Forest Inventory (NFI) data and nationwide airborne laser scanning (ALS) data. In plantation forestry, age is usually known. While this is not the case in boreal managed forests, age is still seldom predicted in forest management inventories. Measuring age accurately in situ is also very laborious. On the other hand, tree age is one of the accurately measured sample tree attributes in NFI field data. Many countries also have a nationwide coverage of airborne laser scanning (ALS) data. In this study, we merged these data sources and constructed a nationwide, area-based model for stand age.

Results
While constructing the model, we omitted old forests from the data, since the correlation between ALS height metrics and stand age diminished at stands with age > 100 years. Additionally, the effect of growth conditions was considerable, so we also utilized different geographical and NFI variables such as site fertility and soil type in the modeling. The resultant nationwide model for the stand age of managed forests yielded a root mean square error (RMSE) of about 14 years. The model could be improved further by additional forest structure variables, but such information may not be available in practice.

Conclusions
The results showed that the prediction of stand age by ALS, geographical and NFI information was challenging, but still possible with moderate success. This study is an example of the joint use of NFI and nationwide ALS data and re-use of NFI data in research.
Experimental design and evaluation of a moisture responsive sports bra
Authors: Gorea Adriana , Baytar Fatma , Sanders Eulanda A. 
Published: July 2020

AbstractWomen prefer to wear a sports bra not only for exercising, but also during resting and daily activities, highlighting deficiencies in current sports bra designs. The purpose of this study was to design, develop, and evaluate a sports bra that offers responsive behavior, in terms of breast support and comfort, both during rest and running conditions. A biomimetic design framework guided the conceptual phase, and moisture responsive plant biomechanics offered a feasible functional model. Fourteen sports bras were developed and wear- tested using college athletes. The moisture responsive panels inside the bra absorbed the sweat generated during running, making the fabric thicker when wet (statistically significant via 3D body scanning results), while maintaining comfort and perceived breast support through sweaty conditions (confirmed via questionnaire results). Adjustments to the underbust band tightness should be pursued, aiming to further improve sports bra functionality, promoting women health and their lifestyles.
Monotonic and dynamic properties of riverbed sand and hill-slope soils of seismically active North-east India for ground engineering applications
Authors: Kumar Shiv Shankar , Dey Arindam , Krishna A. Murali 
Published: July 2020

AbstractThe stress–strain characteristics of soil under monotonic loading conditions and the dynamic properties of soils under cyclic loading are necessary for foundation engineering, ground response analysis and soil structure interaction studies. In the absence of site/region-specific properties, it is a common practice to use representative parameters based on the index properties of soil and available standard correlations. Such correlations might be inadequate for regional soils of varying index properties. Based on monotonic and cyclic triaxial tests, this study reports the monotonic and dynamic soil properties of the prevalent soils from the northeastern region of India, namely the cohesionless, cohesive and silty-sandy soils. It is observed that monotonic response of cohesionless soil is mostly influenced by the initial relative density, while the response of cohesive and silty-sands are primarily influenced by the effective confining pressure and degree of saturation. The cyclic triaxial tests revealed that, irrespective of the soil type, the strain-dependent modulus reduction and especially the damping ratio curves are noticeably different from available standards. The study highlights the importance of identifying the site/region specific soil properties for their usage in GRA and SSI applications.
A qualitative exploration of teachers’ perspective on smartphones usage in higher education in developing countries
Authors: Iqbal Shakeel , Bhatti Zeeshan Ahmed 
Published: July 2020

AbstractRecently, Smartphone sales have surpassed the sales of all other computing devices including desktops, laptops and tablet PCs. Moreover, Smartphones have become a primary device to access the Internet as well as the most commonly used infotainment gadget among the Generations Y and Z (those born in 80s and 90s). Despite this widespread adoption of Smartphones among the youth, its usage in higher education is still a novice idea specifically in developing countries. This study is aimed at capturing the views of faculty members regarding usage of Smartphones for promoting learning at the tertiary level. In-depth interviews of 22 faculty members from different academic departments were conducted for this purpose. Responses of the interviewees were recorded which were later transcribed and analyzed to draw inferences. Results of this study indicate that the faculty members considered Smartphones to be an effective medium for off-campus learning and communication with peers and students. They also considered Smartphones suitable for explaining complex topics to their students as audio-visual content available over the Internet can easily be shared. However, majority of the respondents were skeptical about using Smartphones for educational purposes as they considered them to be a source of distraction, wastage of time, technostress, and emotional detachment. Moreover, they reported small size of both the screen and keyboard as an important limiting factor undermining the effective use of Smartphones in education. Lack of training and support, lack of technical knowledge and background, excessive work load and lack of incentives for using technology in education were reported as major barriers in adoption of Smartphones in higher learning landscape.
Evaluation of WGS-subtyping methods for epidemiological surveillance of foodborne salmonellosis
Authors: Mohammed Manal , Thapa Salina 
Published: July 2020

Abstract
Background
Salmonellosis is one of the most common foodborne diseases worldwide. Although human infection by non-typhoidal Salmonella (NTS) enterica subspecies enterica is associated primarily with a self-limiting diarrhoeal illness, invasive bacterial infections (such as septicaemia, bacteraemia and meningitis) were also reported. Human outbreaks of NTS were reported in several countries all over the world including developing as well as high-income countries. Conventional laboratory methods such as pulsed field gel electrophoresis (PFGE) do not display adequate discrimination and have their limitations in epidemiological surveillance. It is therefore very crucial to use accurate, reliable and highly discriminative subtyping methods for epidemiological characterisation and outbreak investigation.

Methods
Here, we used different whole genome sequence (WGS)-based subtyping methods for retrospective investigation of two different outbreaks of Salmonella Typhimurium and Salmonella Dublin that occurred in 2013 in UK and Ireland respectively.

Results
Single nucleotide polymorphism (SNP)-based cluster analysis of Salmonella Typhimurium genomes revealed well supported clades, that were concordant with epidemiologically defined outbreak and confirmed the source of outbreak is due to consumption of contaminated mayonnaise. SNP-analyses of Salmonella Dublin genomes confirmed the outbreak however the source of infection could not be determined. The core genome multilocus sequence typing (cgMLST) was discriminatory and separated the outbreak strains of Salmonella Dublin from the non-outbreak strains that were concordant with the epidemiological data however cgMLST could neither discriminate between the outbreak and non-outbreak strains of Salmonella Typhimurium nor confirm that contaminated mayonnaise is the source of infection, On the other hand, other WGS-based subtyping methods including multilocus sequence typing (MLST), ribosomal MLST (rMLST), whole genome MLST (wgMLST), clustered regularly interspaced short palindromic repeats (CRISPRs), prophage sequence profiling, antibiotic resistance profile and plasmid typing methods were less discriminatory and could not confirm the source of the outbreak.

Conclusions
Foodborne salmonellosis is an important concern for public health therefore, it is crucial to use accurate, reliable and highly discriminative subtyping methods for epidemiological surveillance and outbreak investigation. In this study, we showed that SNP-based analyses do not only have the ability to confirm the occurrence of the outbreak but also to provide definitive evidence of the source of the outbreak in real-time.