bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revised synthesis of the rift and drift history of the Gulf of Mexico and surrounding regions in the light of improved age dating of the Middle Jurassic salt
Authors: Pindell James , Villagómez Diego , Molina-Garza Roberto , Graham Rod , Weber Bodo 
Published: August 2020

Abstract

We present an updated, internally consistent synthesis of the Permo-Triassic assembly and Mesozoic evolution of the Gulf of Mexico, Mexico, Florida–Bahamas and northern South America (Guiana margin and northern Andes), incorporating advances at regional, field and geochronological levels. The recently determined Bajocian age for salt deposition (using
87
Sr/
86
Sr isotopes) is integrated by modifying the plate kinematic framework with a new Equatorial Atlantic reconstruction that expands the gap between the Americas by 180 km over many kinematic frameworks. NW–SE synrift lithospheric extension along western Florida–Bahamas is estimated at 40%, implying thinned continental crust beneath Great Bank, Bahamas, the conjugate for the Guianas Basin margin. In cordilleran Mexico (excluding the Yucatán Block), we propose two new means by which continental crust migrated into the ‘Colombian overlap position’ of Pangaean reconstructions. The first involved Jurassic–earliest Cretaceous sinistral displacement of the Oaxaca Block along a NW–SE ‘North Oaxaca Transfer’ through or adjacent to the Cuicateco Belt. The second applies to the continental crust in eastern Mexico to the north of Cuicateco, a region we refer to as ‘peninsular Mexico’. There, most Mesozoic basement faults trend NW–SE, and the common occurrence of Permian mid-crustal anatectic basement directly beneath Mesozoic red beds, salt and marine strata suggests extreme extension prior to the onset of sedimentation. Because these Mesozoic sedimentary sections typically sum to 3–8 km in thickness, the post-rift crust of peninsular Mexico probably averaged about 25 km in thickness before later orogenesis. Our reconstructions suggest that this Triassic–Middle Jurassic extension approached 100%, beginning with overthickened Alleghanian (Permian) crust about 50 km in thickness in palaeo-northern Mexico, and was accompanied by a significant sinistral component broadly distributed across the rift array. The updated model provides an exploration and kinematic framework for the entire region.
Moving Genomics to Routine Care
Authors: Aryan Zahra , Szanto Attila , Pantazi Angeliki , Reddi Tejaswini , Rheinstein Carolyn , Powers Winslow , Wilson Evan , Deo Rahul C. , Chowdhury Shimul , Salz Lisa , Dimmock David , Nahas Shareef , Benson Wendy , Kingsmore Stephen F. , MacRae Calum A. , Vuzman Dana 
Published: August 2020

Background:Whole-genome sequencing (WGS) costs are falling, yet, outside oncology, this information is seldom used in adult clinics. We piloted a rapid WGS (rWGS) workflow, focusing initially on estimating power for a feasibility study of introducing genome information into acute cardiovascular care.Methods:A prospective implementation study was conducted to test the feasibility and clinical utility of rWGS in acute cardiovascular care. rWGS was performed on 50 adult patients with acute cardiovascular events and cardiac arrest survivors, testing for primary and secondary disease-causing variants, cardiovascular-related pharmacogenomics, and carrier status for recessive diseases. The impact of returning rWGS results on short-term clinical care of participants was investigated. The utility of polygenic risk scores to stratify coronary artery disease was also assessed.Results:Pathogenic variants, typically secondary findings, were identified in 20% (95% CI, 11.7–34.3). About 60% (95% CI, 46.2–72.4) of participants were carriers for one or more recessive traits, most commonly inHFEandSERPINA1genes. Although 64% (95% CI, 50.1–75.9) of participants carried at least one pharmacogenetic variant of cardiovascular relevance, these were actionable in only 14% (95% CI, 7–26.2). Coronary artery disease prevalence among participants at the 95th percentile of polygenic risk score was 88.2% (95% CI, 71.8–95.7).Conclusions:We demonstrated the feasibility of rWGS integration into the inpatient management of adults with acute cardiovascular events. Our pilot identified pathogenic variants in one out of 5 acute vascular patients. Integrating rWGS in clinical care will progressively increase actionability.
Continuous Neuromuscular Blockade Following Successful Resuscitation From Cardiac Arrest: A Randomized Trial
Authors: Moskowitz Ari , Andersen Lars W. , Rittenberger Jon C. , Swor Robert , Seethala Raghu R. , Kurz Michael C. , Berg Katherine M. , Chase Maureen , Cocchi Michael N. , Grossestreuer Anne V. , Liu Xiaowen , Holmberg Mathias J. , Callaway Clifton W. , Donnino Michael W. 
Published: August 2020

Background
Neuromuscular blockade (NMB) agents are often administered to control shivering during targeted temperature management following cardiac arrest. In this study, we hypothesized that early, continuous NMB would result in a greater reduction in serum lactate levels among comatose patients after cardiac arrest.

Methods and Results

Randomized trial of continuous NMB for 24 hours versus usual care following cardiac arrest conducted at 5 urban centers in the United States. Adult patients who achieved return of spontaneous circulation, remained unresponsive, and underwent targeted temperature management after cardiac arrest were included. The primary outcome was change in lactate over 24 hours. A total of 83 patients were randomized, and 80 were analyzed (37 and 43 in the NMB and usual care arms, respectively). There was no significant interaction between time and treatment group with respect to change in lactate over 24 hours (median lactate change from 4.2 to 2.0 mmol/L [−2.2 mmol/L] in the NMB arm versus 4.0 to 1.7 mmol/L [−2.3 mmol/L] in the usual care arm; geometric mean difference, 1.3 [95% CI, 1.0–1.8];
P
=0.07 for the interaction term). There was no difference in hospital survival (38% [NMB] versus 33% [usual care];
P
=0.63) or survival with good functional outcome (30% [NMB] versus 21% [usual care];
P
=0.35). There were no adverse events in either arm attributed to study interventions.

Conclusions
Continuous NMB compared with usual care did not reduce lactate over the first 24 hours after enrollment compared with usual care. There was no difference in overall hospital survival, hospital survival with good neurologic outcome, or adverse events.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02260258.
Marital Networks and Portfolios of Prestige
Authors: Dluhošová Táňa 
Published: August 2020

Abstract
Many of today’s most successful Taiwanese companies are linked to prominent kin groups. Expanding existing historical scholarship, which has focused on elite families individually, the article opens up a broader perspective by investigating Taiwanese elites as a social group, albeit a heterogeneous one. Based on a dataset comprising family members and their relationships, the article first describes this marital network of 1,271 families. Subsequently, following a Bourdieusian approach, it analyses distinct elite groups and their engagement in multiple fields of activity, information about which is stored in TBIO (Taiwan Biographical Ontology), a biographical database established by the author. The analysis reveals the existence of characteristic combinations of capital—dubbed here ‘portfolios of prestige’—which allowed these families to gain and maintain their positions of influence. In combining Digital Humanities methods and sociological approaches, the article thus identifies salient structural features of Taiwanese elites which have rarely been highlighted and opens up new prospects for future research.
Systematic revision of the caddisfly genus Machairocentron Schmid (Trichoptera: Psychomyioidea: Xiphocentronidae)
Authors: Vilarino Albane , Holzenthal Ralph W. 
Published: August 2020

Abstract
The genus Machairocentron is revised and its included species, M. ascanius Schmid 1982, M. echinatum (Flint 1981), M. falciforme Pes & Hamada 2013, M. lucumon Schmid 1982, M. tarpeia Schmid 1982, and M. teucrus Schmid 1982, are redescribed and illustrated based on type specimens. Two new species from Costa Rica, M. chorotegae sp. nov. and M. eugeniarguedasae sp. nov., and one from Venezuela, M. kalinae sp. nov., are described. An identification key for the Machairocentron genus is also provided.
The Role of the Karaites in the Transmission of the Hebrew Bible and Their Practice of Transcribing It into Arabic Script
Authors: Khan Geoffrey 
Published: August 2020

Abstract
In the Middle Ages the Karaite Jews in the Islamic world used both Arabic and Hebrew script in their writings. They wrote not only Arabic texts in Arabic script but also many of their Hebrew Bibles in Arabic transcription. The Rabbanites, by contrast, used Hebrew script for writing both Arabic and Hebrew. This paper examines the association of the Karaites with the Masoretic transmission of the Hebrew Bible and the motivation for their transcribing the Bible into Arabic script. It is argued that the Arabic transcriptions reflect the polemical stance of the Karaites against the bases of scriptural authority of the Rabbinites and an advanced degree of rapprochement of the Karaites with the Muslim environment. They represent a convergence with the external form of the Muslim Arabic Qurʾān and also with the concepts of authority associated with the transmission of Muslim scripture.
Crop water stress index relationship with soybean seed, protein and oil yield under varying irrigation regimes in a Mediterranean environment
Authors: Vamvakoulas Christos , Argyrokastritis Ioannis , Papastylianou Panayiota , Papatheohari Yolanda , Alexandris Stavros 
Published: August 2020

ABSTRACT
A two-year field experiment was conducted to determine the effect of water stress, including Crop Water Stress Index (CWSI), on seed, protein and oil yields, for two hybrids of drip-irrigated soybean in Central Greece. The experiment was set up as a split plot design with four replicates, five main plots (irrigation treatments) and two sub-plots (soybean hybrids, ‘PR91M10’ and ‘PR92B63’). Irrigation was applied to provide 100, 75, 50 and 25% of the crop evapotranspiration needs and 0% non-irrigated. Biomass weight, seed yield, oil and protein concentration were measured after harvest. To compute CWSI, lower and upper baselines were developed based on the canopy temperature measurements of I100 and I0 treatments, respectively. Deficit irrigation had a significant effect on biomass, seed, protein and oil yields. Hybrid PR92B63 was more responsive to irrigation and showed higher biomass, seed protein and oil yields, while the more sensitive hybrid PR91M10 had the ability to maintain productivity with increasing degrees of water stress. The rain-fed treatments significantly reduced biomass production and seed yield compared with the fully-irrigated ones. The highest and the lowest protein and oil yields were obtained in the I100 and I0 treatments respectively in both years and cultivars. Statistically significant exponential relationships were determined between CWSI and biomass, seed, protein and oil yields. Generally, CWSI could be used to measure crop water status and to improve irrigation scheduling of the crop and 0.10 for PR92B63 and 0.19 for PR91M10 could be offered as threshold values under the climatic conditions of the region.
Assessing Risk for Mortality in Trauma: The Value of Admission Hemoglobin A1c
Authors: Edwards Jacob D. , Flood Dylan M. N. , Bayouth Lilly A. , Archie William , Irish William , Toschlog Eric A. , Newell Mark A. 
Published: August 2020

Background Recent efforts have been made to identify admission characteristics of trauma patients that are associated with increased risk of mortality. Contemporary literature has established an increased risk of mortality with admission hyperglycemia. However, the effects of longstanding hyperglycemia, as surrogated by hemoglobin A1c (HbA1c), has not been studied. Methods A prospective trauma database was retrospectively reviewed identifying patients with collected HbA1c at admission. Three cohorts were defined by HbA1c: normal (N), <5.7; prediabetic (PD) 5.7-6.5; and diabetic (D) >6.5. Regression models were used to evaluate the risk of increased hospital and intensive care unit (ICU) length of stay (LOS), ventilator days, and mortality. Relative risk (RR) and 95% CI are provided as measures of significance. Results A total of 2978 patients were included in the analysis (N: n = 1895, PD: n = 744, and D: n = 339). The D cohort was more likely to be older, female, obese, suffered blunt trauma, and triaged at the highest activation acuity level ( P < .0001). Mean injury severity score (ISS) was similar between groups. The D group was more likely to have longer ICU-LOS (RR 1.5; 95% CI 1.10-2.07) and ventilator days (RR 1.52; 95% CI 1.03-2.26) than the N group. Relative to the N group, the risk of mortality was 50% higher in the PD (RR 1.49; 95% CI 1.17-1.90) and in the D cohorts (RR 1.50; 95% CI 1.03-2.18). Discussion Trauma patients with an elevated admission HbA1c have a significantly higher risk of mortality regardless of their history of diabetes. These data add to the body of literature that documents the untoward effect of hyperglycemia on the trauma patient.
Impact of Surgeon-Performed Ultrasound on Treatment of Thyroid Cancer Patients
Authors: Shalaby Mahmoud , Hadedeya Deena , Lee Grace S. , Toraih Eman , Kandil Emad 
Published: August 2020

Background The 2015 American Thyroid Association Management Guidelines for patients with thyroid nodules recommended a comprehensive sonographic evaluation of thyroid nodules’ characteristics and the presence of any suspicious cervical lymph nodes (LNs) in the central and lateral compartments. This detailed sonographic assessment is still not routinely performed. We hypothesized that an endocrine surgeon-performed ultrasound (SUS) significantly enhances the management of thyroid cancer patients when compared with referral ultrasound (RUS). Methods We conducted a retrospective review of 267 consecutive thyroid surgery patients who were diagnosed with thyroid cancer on final pathology. All patients had undergone a SUS, but only 130 cohorts with both RUS and SUS were included. Features of thyroid nodules and LN and changes in the management plan were recorded. Results Based on SUS assessment, 26 patients (20%) were noted to have suspicious thyroid nodules which warranted a fine-needle aspiration (FNA) and were missed in RUS. On FNA, there were 12 patients with Bethesda categories III/IV and 14 patients with Bethesda V/VI. Those 26 patients were found to have a malignancy in the final pathology assessment. Thirty-eight patients (29.2%) were noted to have suspicious central/lateral neck findings on SUS but were not reported in RUS. Additionally, 8 patients (6.1%) were found to have a parathyroid adenoma by SUS and required concurrent parathyroidectomy. Discussion A comprehensive neck ultrasound in thyroid cancer patients, performed by their endocrine surgeon, could enhance management planning and outcomes. This finding highlights the critical need for education and improvement of routine neck ultrasonographic examination performed in the community.
Management of FDG avid Benign Sinonasal Schneiderian Papilloma: A Case Report and Review of the Literature
Authors: Shafqat Iram , Ho Allen S. , Manzoor Daniel , Balzer Bonnie , Wu Arthur W. 
Published: August 2020

Background: The inverted and oncocytic subtypes of sinonasal Schneiderian papillomas are benign tumors with possible rare malignant transformation and are typically managed with complete surgical resection and close follow-up. While computed tomography (CT) and magnetic resonance imaging (MRI) are mainstays in preoperative evaluation of bony invasion and soft tissue extension of the lesion, their imaging characteristics by 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) is less well characterized. Objective: To describe the clinical presentation and management of a PET positive sinonasal lesion. To conduct a literature review of FDG uptake in benign sinonasal papillomas. Methods: Case report (n = 1) and literature review of similar cases (n = 32). Results: We report the case of a 69-year-old man presenting with an isolated left maxillary sinus mass with avid FDG uptake, discovered on PET/CT imaging. An endoscopic left maxillary mega-antrostomy provided successful definitive treatment for final pathologic diagnosis of oncocytic papilloma. Literature review of cases of sinonasal papillomas with avid FDG uptake found that oncocytic papillomas, on average, exhibit greater uptake than inverted papillomas and both may be mistaken as malignancies on PET. Conclusion: While PET imaging demonstrating avid FDG uptake is associated with an increased risk of malignancy, it does not rule out the possibility of a benign sinonasal papilloma nor other benign inflammatory lesions. Particularly, oncocytic papillomas may have very high FDG uptake and mimic malignant lesions.
Risk of incident dementia in late-life depression treated with antidepressants: A nationwide population cohort study
Authors: Su Jian-An , Chang Chih-Cheng , Yang Yao-Hsu , Chen Ko-Jung , Li Yueh-Ping , Lin Chung-Ying 
Published: August 2020

Background: Antidepressants are frequently used to treat depression in patients with dementia. In addition, late-life depression is associated with the incidence of subsequent cognitive impairment or dementia. However, the association between exposure to antidepressants in late-life depression and the development of incident dementia remains understudied. Methods: Through a population-based retrospective cohort design, data were extracted from the Taiwan National Health Insurance Research Dataset of medical claims registered from 1998–2013. We collected data of individuals who had received a new diagnosis of depression between 2000 and 2007. We excluded those who received a diagnosis of depression and were given antidepressants before 2000 and those younger than 60 years. The primary outcome was the occurrence of incident dementia. The time from the prescription of antidepressants or the diagnosis of depression until the outcome or the end of 2013 was calculated as the time to event. A total of 563,918 cases were included and were divided into either antidepressant users or antidepressant nonusers. Cox proportional hazards models were used to calculate the hazard ratio and 95% confidence interval. Results: Exposure to antidepressants did not increase the risk of dementia in patients with late-life depression at either a low exposure dosage (hazard ratio: 1.06, 95% confidence interval: 0.91–1.23) or a high exposure dosage (hazard ratio: 1.07, 95% confidence interval: 0.95–1.20). To confirm the validity of our results, we performed a sensitivity analysis and subgroup analysis, and the post-hoc results were consistent with the main results. Conclusion: Antidepressants did not increase the risk of incident dementia in patients with late-life depression.
Factors impacting self-pay pediatric vaccine utilization in China: a large-scale maternal survey
Authors: Li Xinxin , Lu Haiyan , Wu Han , Chen Qiuhua , Wu Ping , Pan Qingjun 
Published: August 2020

Objectives Utilization of self-pay vaccines worldwide is very low, especially in China; the reasons for this are unclear. We aimed to identify factors that impact the decision among Chinese mothers to utilize self-pay vaccines for their children. Methods Mothers who were hospitalized at two hospitals in Zhanjiang City and who agreed to participate by completing the required questionnaire were eligible for this study. Results In total, 7518 respondents (n = 7592) completed the questionnaire and were included in this survey. The self-pay option was largely elected by mothers with one child, compared with those who had two or more children. Similarly, utilization by workers at government agencies and organizations was higher than that among factory workers or unemployed respondents. Mothers with a college degree or above had higher utilization than those with a high school level education or lower. The main issues affecting maternal decisions to utilize self-pay pediatric vaccines were safety, the protective effect, and the high cost. Conclusion Mothers with higher socioeconomic status were more inclined to self-pay for pediatric vaccines. Steps taken to enhance public awareness about the safety and protective benefits of self-pay vaccines, as well as lowering their cost will likely encourage broader utilization of these vaccines.
Effect of hybrid teaching incorporating problem-based learning on student performance in pathophysiology
Authors: Guo Jianhong , Li Lihong , Bu Haolin , Feng Miao , Yang Yanping , Zhang Yang , Liu Fu , Liu Qinghua , Li Xiaqing , Jiao Xiangying 
Published: August 2020

Objective To compare the effectiveness of traditional and hybrid teaching strategies in pathophysiology and to conduct a survey of students’ opinions about the hybrid teaching strategy. Methods A hybrid pathophysiology course was developed by combining traditional lectures, case- or problem-based learning, group discussion and several quizzes. A total of 167 students were assigned to the hybrid teaching group and 118 students assigned to the traditional lecture group. Results Compared with students who received traditional lectures, no students in the hybrid teaching class failed the final examination. The percentage of students with high scores was significantly higher in the hybrid teaching class. In addition, 73.7% of students in the hybrid teaching class expressed substantial interest in pathophysiology during the course, and 83% of these students felt they had received essential training and acquired the ability to solve clinical case problems. Conclusion The hybrid teaching strategy is an advanced approach that encourages students to actively learn teaching materials and solve practical clinical problems, and that promotes student interest in pathophysiology.
Autoimmune-related encephalitis during treatment with nivolumab for advanced head and neck cancer: a case report
Authors: Guidi Alessandro , Violati Martina , Blasi Miriam , Ferrari Elettra , Luciani Andrea , Codecà Carla , Ferrari Daris 
Published: August 2020

Introduction: Head and neck cancer represents a variety of tumors involving different organs in the cervical district, burdened by poor prognosis when diagnosed in an advanced stage. Immunotherapy with both anti-PD-1 nivolumab and pembrolizumab has the aim of increasing overall survival for patients with this malignancy. We report the first case of immune-related encephalitis caused by nivolumab in this setting of disease and present a brief review of the literature. Case description: A 60-year-old woman had been treated with concomitant chemoradiotherapy for a locally advanced human papillomavirus–negative squamous cell carcinoma of the tonsil. After local recurrence, she was treated with platinum-based first-line chemotherapy, followed by nivolumab at further progression within 6 months. Nivolumab was administered for 19 weeks, then discontinued due to the occurrence of immune-related hypothyroidism and grade 2 diarrhea. A month after the onset of the endocrinopathy, the patient also developed steroid-responsive encephalitis, considered as a consequence of anti-PD-1 therapy. One year after discontinuation of immunotherapy, toxicities have resolved and the patient is maintaining a complete radiologic response. Conclusions: Immunotherapy is a relatively new and promising therapy in the field of oncology. Its mechanism of action, which aims to stimulate the immune system against cancer cells, is not comparable to systemic and cytotoxic chemotherapy, which directly attacks and destroys malignant cells. Despite these differences, immunotherapy is not to be considered free from side effects, sometimes life-threatening.