bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Modifiable Factors Linking Parenting and Sleep in Racial/Ethnic Minority Children
Authors: Daniel Lauren C , Childress Jessica L , Flannery Jamie L , Weaver-Rogers Stephanie , Garcia Wanda I , Bonilla-Santiago Gloria , Williamson Ariel A 
Published: May 2020

Abstract

Background
Young children from racial and ethnic minority backgrounds are at risk for poor sleep, yet few studies have tested behavioral interventions in diverse samples. This study tests factors that could contribute to associations between parenting skills and child sleep to inform interventions for children at risk of poor sleep outcomes. Specifically, we examined household chaos, caregiver sleep knowledge, and caregiver sleep quality as putative mediators that may be relevant to interventions seeking to improve child sleep.

Methods
Caregivers (M age 31.83 years; 46.2% African American; 52.1% Hispanic/Latinx, 95% female) of 119 1- to 5-year-old children (M age 3.99 years; 43.7% African American; 42.0% Hispanic/Latinx, 14.3% biracial; 51.3% female) completed measures of parenting practices, child and caregiver sleep, household chaos, and sleep knowledge. Indices of pediatric insomnia symptoms (difficulty falling/remaining asleep) and sleep health (sleep duration/hygiene) were constructed based on previous research. Parallel mediation models were conducted using ordinary least squares path analysis.

Results
Lower household chaos significantly attenuated the relationship between positive parenting skills and better child sleep health, suggesting chaos may serve as a potential mediator. There were no significant contributing factors in the pediatric insomnia model. Sleep knowledge was related to sleep health and caregiver sleep quality was related to pediatric insomnia, independent of parenting skills.

Conclusion
Interventions to improve sleep in early childhood may be enhanced by targeting parenting skills and household routines to reduce chaos. Future longitudinal research is needed to test household chaos and other potential mediators of child sleep outcomes over time.
How Peer Conflict Profiles and Socio-Demographic Factors Influence Type 1 Diabetes Adaptation
Authors: Banks Gabrielle G , Berlin Kristoffer S , Keenan Mary E , Cook Jessica , Klages Kimberly L , Rybak Tiffany M , Ankney Rachel , Semenkovich Katherine , Cohen Robert , Thurston Idia , Diaz-Thomas Alicia , Alemzadeh Ramin , Eddington Angelica 
Published: May 2020

Abstract

Objective
This study aimed to (a) validate the factor structure for a measure of peer conflict in youth with type 1 diabetes (T1D); (b) determine empirical patterns of peer conflict in terms of context (friend vs. nonfriend) and content (diabetes-specific vs. general) within a broader context of socio-demographic factors; and (c) examine how these patterns and socio-demographic factors relate to adolescents’ T1D adherence, quality of life, and glycemic control (HbA1c).

Methods
Youth with T1D (N = 178), ages 12–18, reported demographic variables, illness duration, adherence, quality of life, and peer conflict. HbA1c was extracted from medical records. Confirmatory factor analysis validated a factor structure for the Diabetes Peer Conflict Scale (DPCS) and latent profile analysis (LPA) determined profiles of peer conflict.

Results
A four-factor structure emerged for the DPCS: general friend conflict, general nonfriend conflict, T1D friend conflict, and T1D nonfriend conflict. Using these factors as indicators in LPA, four profiles were confirmed: (a) Low Overall Conflict (LOC) and (b) Moderate Overall Conflict (MOC), (c) a Nonfriend Conflict (NFC), and (d) a Friend Conflict (FC) profile. Differences were not identified between diabetes specific versus general conflict. Socio-demographic variables did not predict class membership. The LOC profile reported the highest quality of life and best glycemic control, whereas the FC profile reported the lowest adherence behaviors. Conclusions: Peer conflict uniquely contributes to diabetes adaptation above and beyond socio-demographic and illness factors.
Health Disparities in Transgender and Gender Expansive Adolescents: A Topical Review From a Minority Stress Framework
Authors: Delozier Alexandria M , Kamody Rebecca C , Rodgers Scott , Chen Diane 
Published: May 2020

Abstract

Objective
To present a topical review of minority stressors contributing to psychosocial and physical health disparities in transgender and gender expansive (TGE) adolescents.

Methods
We conducted a topical review of original research studies focused on distal stressors (e.g., discrimination; victimization; rejection; nonaffirmation), proximal stressors (e.g., expected rejection; identity concealment; internalized transphobia), and resilience factors (e.g., community connectedness; pride; parental support) and mental and physical health outcomes.

Results
Extant literature suggests that TGE adolescents experience a host of gender minority stressors and are at heightened risk for negative health outcomes; however, limited research has directly applied the gender minority stress framework to the experiences of TGE adolescents. Most research to date has focused on distal minority stressors and single path models to negative health outcomes, which do not account for the complex interplay between chronic minority stress, individual resilience factors, and health outcomes. Research examining proximal stressors and resilience factors is particularly scarce.

Conclusions
The gender minority stress model is a helpful framework for understanding how minority stressors contribute to health disparities and poor health outcomes among TGE adolescents. Future research should include multiple path models that examine relations between gender minority stressors, resilience factors, and health outcomes in large, nationally representative samples of TGE adolescents. Clinically, adaptations of evidence-based interventions to account for gender minority stressors may increase effectiveness of interventions for TGE adolescents and reduce health disparities in this population of vulnerable youth.
Getting more bark for your buck: nitrogen economy of deciduous forest trees
Authors: Castro-Rodríguez Vanessa , Ávila Concepción , Cánovas Francisco M 
Published: May 2020

This article comments on:
Li G, Lin R, Egekwu C, Blakeslee J, Lin J, Pettengill E, Murphy AS, Peer WA, Islam N, Babst BA, Gao F, Komarov S, Tai Y-C, Coleman GD. 2020. Seasonal nitrogen remobilization and the role of auxin transport in poplar trees. Journal of Experimental Botany 71, 4512–4530.
The SAMI galaxy survey: gas velocity dispersions in low-z star-forming galaxies and the drivers of turbulence
Authors: Varidel Mathew R , Croom Scott M , Lewis Geraint F , Fisher Deanne B , Glazebrook Karl , Catinella Barbara , Cortese Luca , Krumholz Mark R , Bland-Hawthorn Joss , Bryant Julia J , Groves Brent , Brough Sarah , Federrath Christoph , Lawrence Jon S , Lorente Nuria P , Owers Matt S , Richards Samuel N , López-Sánchez Ángel R , Sweet Sarah M , van de Sande Jesse , Vaughan Sam P 
Published: May 2020

ABSTRACT
We infer the intrinsic ionized gas kinematics for 383 star-forming galaxies across a range of integrated star formation rates (SFR ∈ [10−3, 102] M⊙ yr−1) at z ≲ 0.1 using a consistent 3D forward-modelling technique. The total sample is a combination of galaxies from the Sydney-AAO Multiobject Integral field Spectrograph (SAMI) Galaxy survey and DYnamics of Newly Assembled Massive Objects survey. For typical low-z galaxies taken from the SAMI Galaxy Survey, we find the vertical velocity dispersion (σv,z) to be positively correlated with measures of SFR, stellar mass, H i gas mass, and rotational velocity. The greatest correlation is with SFR surface density (ΣSFR). Using the total sample, we find σv,z increases slowly as a function of integrated SFR in the range SFR ∈ [10−3, 1]  M⊙ yr−1 from 17 ± 3 to 24 ± 5 km s−1 followed by a steeper increase up to σv,z ∼80 km s−1 for SFR ≳ 1 M⊙ yr−1. This is consistent with recent theoretical models that suggest a σv,z floor driven by star formation feedback processes with an upturn in σv,z at higher SFR driven by gravitational transport of gas through the disc.
Physics of tidal dissipation in early-type stars and white dwarfs: hydrodynamical simulations of internal gravity wave breaking in stellar envelopes
Authors: Su Yubo , Lecoanet Daniel , Lai Dong 
Published: May 2020

ABSTRACT
In binaries composed of either early-type stars or white dwarfs, the dominant tidal process involves the excitation of internal gravity waves (IGWs), which propagate towards the stellar surface, and their dissipation via non-linear wave breaking. We perform 2D hydrodynamical simulations of this wave breaking process in a stratified, isothermal atmosphere. We find that, after an initial transient phase, the dissipation of the IGWs naturally generates a sharp critical layer, separating the lower stationary region (with no mean flow) and the upper ‘synchronized’ region (with the mean flow velocity equal to the horizontal wave phase speed). While the critical layer is steepened by absorption of these waves, it is simultaneously broadened by Kelvin–Helmholtz instabilities such that, in steady state, the critical layer width is determined by the Richardson criterion. We study the absorption and reflection of incident waves off the critical layer and provide analytical formulae describing its long-term evolution. The result of this study is important for characterizing the evolution of tidally heated white dwarfs and other binary stars.
Snow lines can be thermally unstable
Authors: Owen James E 
Published: May 2020

ABSTRACT
Volatile species in protoplanetary discs can undergo a phase change from vapour to solid. These ‘snow lines’ can play vital roles in planet formation at all scales, from dust coagulation to planetary migration. In the outer regions of protoplanetary discs, the temperature profile is set by the absorption of reprocessed stellar light by the solids. Further, the temperature profile sets the distribution of solids through sublimation and condensation at various snow lines. Hence, the snow line position depends on the temperature profile and vice versa. We show that this coupling can be thermally unstable, such that a patch of the disc at a snow line will produce either runaway sublimation or condensation. This thermal instability arises at moderate optical depths, where heating by absorption of reprocessed stellar light from the disc’s atmosphere is optically thick, yet cooling is optically thin. Since volatiles in the solid phase drift much faster than volatiles in the vapour phase, this thermal instability results in a limit cycle. The snow line progressively moves in, condensing volatiles, before receding, as the volatiles sublimate. Using numerical simulations, we study the evolution of the carbon monoxide (CO) snow line. We find the CO snow line is thermally unstable under typical disc conditions and evolves inwards from ∼50 to ∼30 au on time-scales from 1000 to 10 000 yr. The CO snow line spends between ${\sim}10{{\ \rm per\ cent}}\,\mathrm{ and}\,50{{\ \rm per\ cent}}$ of its time at smaller separations, where the exact value is sensitive to the total opacity and turbulent viscosity. The evolving snow line also creates ring-like structures in the solid distribution interior to the snow line. Multiple ring-like structures created by moving snow lines could potentially explain the substructures seen in many ALMA images.
On the Geometry of the X-ray emission from pulsars a consistent inclination and beaming solution for the Be/X-ray pulsar SXP 1062
Authors: Cappallo R C , Laycock S G T , Christodoulou D M , Roy A , Bhattacharya S , Coe M J , Zezas A 
Published: May 2020

ABSTRACT
SXP 1062 is a long-period X-ray pulsar (XRP) with a Be optical companion located in the Small Magellanic Cloud. First discovered in 2010 from XMM–Newton data, it has been the target of multiple observational campaigns due to the seeming incongruity between its long spin period and recent birth. In our continuing modelling efforts to determine the inclination angle (i) and magnetic axis angle (θ) of XRPs, we have fitted 19 pulse profiles from SXP 1062 with our pulsar model, Polestar, including three consecutive Chandra observations taken during the trailing end of a Type I outburst. These fittings have resulted in most likely values of i = 76○ ± 2○ and θ = 40○ ± 9○. SXP 1062 mostly displays a stable double-peaked pulse profile with the peaks separated by roughly a third of a phase, but recently the pulsar has spun up and widened to a spacing of roughly half of a phase, yet the Polestar fits for i and θ remain constant. Additionally, we note a possible correlation between the X-ray luminosity and the separation of the peaks in the pulse profiles corresponding to the highest luminosity states.
A bipartite thermodynamic-kinetic contribution by an activating mutation to RDF-independent excision by a phage serine integrase
Authors: Fan Hsiu-Fang , Su Bo-Yu , Ma Chien-Hui , Rowley Paul A , Jayaram Makkuni 
Published: May 2020

AbstractStreptomyces phage ϕC31 integrase (Int)—a large serine site-specific recombinase—is autonomous for phage integration (attP x attB recombination) but is dependent on the phage coded gp3, a recombination directionality factor (RDF), for prophage excision (attL x attR recombination). A previously described activating mutation, E449K, induces Int to perform attL x attR recombination in the absence of gp3, albeit with lower efficiency. E449K has no adverse effect on the competence of Int for attP x attB recombination. Int(E449K) resembles Int in gp3 mediated stimulation of attL x attR recombination and inhibition of attP x attB recombination. Using single-molecule analyses, we examined the mechanism by which E449K activates Int for gp3-independent attL x attR recombination. The contribution of E449K is both thermodynamic and kinetic. First, the mutation modulates the relative abundance of Int bound attL-attR site complexes, favoring pre-synaptic (PS) complexes over non-productively bound complexes. Roughly half of the synaptic complexes formed from Int(E449K) pre-synaptic complexes are recombination competent. By contrast, Int yields only inactive synapses. Second, E449K accelerates the dissociation of non-productively bound complexes and inactive synaptic complexes formed by Int. The extra opportunities afforded to Int(E499K) in reattempting synapse formation enhances the probability of success at fruitful synapsis.
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage
Authors: Hayne Cassandra K , Schmidt Casey A , Haque Maira I , Matera A Gregory , Stanley Robin E 
Published: May 2020

AbstractThe splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, TSEN34 and TSEN15). The human TSEN complex additionally co-purifies with the polynucleotide kinase CLP1; however, CLP1’s role in tRNA splicing remains unclear. Mutations in genes encoding all four TSEN subunits, as well as CLP1, are known to cause neurodegenerative disorders, yet the mechanisms underlying the pathogenesis of these disorders are unknown. Here, we developed a recombinant system that produces active TSEN complex. Co-expression of all four TSEN subunits is required for efficient formation and function of the complex. We show that human CLP1 associates with the active TSEN complex, but is not required for tRNA intron cleavage in vitro. Moreover, RNAi knockdown of the Drosophila CLP1 orthologue, cbc, promotes biogenesis of mature tRNAs and circularized tRNA introns (tricRNAs) in vivo. Collectively, these and other findings suggest that CLP1/cbc plays a regulatory role in tRNA splicing by serving as a negative modulator of the direct tRNA ligation pathway in animal cells.
White Matter-Governed Superior Frontal Sulcus Surgical Paradigm: A Radioanatomic Microsurgical Study—Part I
Authors: Monroy-Sosa Alejandro , Chakravarthi Srikant S , Fukui Melanie B , Kura Bhavani , Jennings Jonathan E , Celix Juanita M , Nash Kenneth C , Kassam Mikaeel , Rovin Richard A , Kassam Amin B 
Published: May 2020

Abstract

BACKGROUND
Frontal subcortical and intraventricular pathologies are traditionally accessed via transcortical or interhemispheric-transcallosal corridors.

OBJECTIVE
To describe the microsurgical subcortical anatomy of the superior frontal sulcus (SFS) corridor.

METHODS
Cadaveric dissections were undertaken and correlated with magnetic resonance imaging/diffusion-tensor imaging-Tractography. Surgical cases demonstrated clinical applicability.

RESULTS
SFS was divided into the following divisions: proximal, precentral sulcus to coronal suture; middle, 3-cm anterior to coronal suture; and distal, middle division to the orbital crest. Anatomy was organized as layered circumferential rings projecting radially towards the ventricles: (1) outer ring: at the level of the SFS, the following lengths were measured: (A) precentral sulcus to coronal suture = 2.29 cm, (B) frontal bone projection of superior sagittal sinus (SSS) to SFS = 2.37 cm, (C) superior temporal line to SFS = 3.0 cm, and (D) orbital crest to distal part of SFS = 2.32 cm; and (2) inner ring: (a) medial to SFS, U-fibers, frontal aslant tract (FAT), superior longitudinal fasciculus I (SLF-I), and cingulum bundle, (b) lateral to SFS, U-fibers, (SLF-II), claustrocortical fibers (CCF), and inferior fronto-occipital fasciculus, and (c) intervening fibers, FAT, corona radiata, and CCF. The preferred SFS parafascicular entry point (SFSP-EP) also referred to as the Kassam-Monroy entry point (KM-EP) bisects the distance between the midpupillary line and the SSS and has the following coordinates: x = 2.3 cm (lateral to SSS), y ≥ 3.5 cm (anterior to CS), and z = parallel corona radiata and anterior limb of the internal capsule.

CONCLUSION
SFS corridor can be divided into lateral, medial, and intervening white matter tract segments. Based on morphometric assessment, the optimal SFSP-EP is y ≥ 3.5 cm, x = 2.3 cm, and z = parallel to corona radiata and anterior limb of the internal capsule.
Symptomatic Primary Tethered Optic Chiasm: Technical Case Report
Authors: Byrne Nika , Kochanski Ryan B , Tajudeen Bobby , Byrne Richard W 
Published: May 2020

Abstract

BACKGROUND AND IMPORTANCE
Symptomatic tethering of the optic nerves and chiasm is a rare occurrence and has been reported following both surgical and medical treatment of pituitary adenoma. Here we present a case of primary optic chiasm tethering in a patient with empty sella syndrome.

CLINICAL PRESENTATION
The patient was a 61-yr-old female who presented with progressively worsening bitemporal hemianopsia. Magnetic resonance imaging (MRI) brain revealed an empty sella with herniation of the optic chiasm into the sella. The patient underwent an endoscopic, endonasal/trans-sphenoidal approach to the sella, where the optic chiasm was then detethered via lysis of arachnoid adhesions and ultimately buttressed with an abdominal fat graft. Postoperatively, the patient did well with subjective and objective improvements in her visual fields.

CONCLUSION
We report a rare case of primary tethered optic chiasm, which was successfully treated via an endoscopic, endonasal approach with abdominal fat graft harvest.
Becoming parents again: Challenges affecting grandparent primary caregivers raising their grandchildren
Authors: Martin Ashley , Albrechtsons Daniel , MacDonald Noni , Aumeerally Nadia , Wong Tania 
Published: May 2020

Abstract

Background
A growing number of Canadian children live in the care of their grandparents, called skip-generation families. Reasons for this include teen pregnancy, death of a parent, mental/physical illnesses, and addictions. These grandparents and grandchildren are at increased risk of physical and mental illness, yet have few resources available to them.

Objective
Our study aims to describe the lived experiences of skip-generation families to better identify their needs.

Methods
We conducted semistructured interviews of grandparent primary caregivers from ten households in our community to chronicle their experiences raising their grandchildren. Participants were recruited by paediatricians using convenience sampling. Interviews were recorded, transcribed, and coded using Atlas Ti software, and classified into themes by consensus.

Results
Five primary themes emerged from the interviews: (1) Changes in family dynamics, (2) Psychosocial impact on grandchild and grandparent, (3) Lack of resources for grandparent caregivers, (4) The challenges of parenting later in life, and (5) Resilience inspired by the love of family. Many participants (n=10) described feeling unsupported after assuming care of their grandchildren and identified a need for additional counselling services, financial support and respite care. All (n=11) highlighted that caring for their grandchildren changed their lives in positive ways.

Conclusion
When grandparents are prioritized as primary caregivers for their grandchildren, our study suggests they receive insufficient community resources to meet their emotional, respite and financial needs. Further research involving this population in Canada is required. Paediatricians can play an essential role in recognizing these vulnerable families and advocating for additional supports and services.
Systematic review of methemoglobinemia in acetaminophen poisoning
Authors: Sahu K K , George S V , Siddiqui A D 
Published: May 2020

Summary

Acetaminophen (N-acetyl-p-aminophenol paracetamol (APAP)) toxicity is one of the commonly encountered poisonings by emergency physicians. Methemoglobinemia is an uncommon association and rarely seen in APAP poisoning. The study involves the retrospective analysis of all the published reports on APAP-induced methemoglobinemia from 1968 to 2019.

In total, there were 14 cases with nine females and six males. The median age of the study cohort was 59 years. The most common presenting feature was altered mentation (nine patients) followed by cyanosis (three patients). The intent of consumption was therapeutic (seven cases) vs. suicidal (five cases) attempt. In most cases, the dose of APAP consumption was not known. Aspirin, sulfasalazine, benzocaine spray, nitrate preservative, contaminated water, detergents, and so on where the other agents consumed by the patients in addition to APAP before developing methemoglobinemia. The median MethHb level of the study cohort was 15.85%. Patients were treated with NAC, hemodialysis, methylene blue and ascorbic acid and continuous renal replacement therapy in various combinations. Full recovery was seen in nine patients while four patients died.

APAP toxicity is a well-known and a common entity with multiple sequelae that presents with a variable spectrum of mild to fulminant multiorgan failure. Awareness of non-classical presentations like methemoglobinemia is essential to ensure timely intervention.