bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educação ambiental e educação infantil em dissertações e teses brasileiras: conhecimentos, valores e participação política presentes nas práticas pedagógicas relatadas
Authors: Luccas Marinete Belluzzo , Bonotto Dalva Maria Bianchini 
Published: December 2020

Esse artigo é um recorte da pesquisa de mestrado vinculada ao projeto interinstitucional denominado “Educação ambiental no Brasil: análise da produção acadêmica (dissertações e teses) – EArte”. A pesquisa se fundamenta na Teoria Histórico-Cultural para compreender a aprendizagem e o desenvolvimento infantil e na perspectiva de uma Educação Ambiental Crítica que contemple três dimensões: conhecimentos, valores éticos e estéticos e participação política. Buscamos identificar e analisar a presença dessas três dimensões nas práticas pedagógicas em educação ambiental no contexto escolar da educação infantil relatadas em treze dissertações e teses brasileiras. Trata-se de uma pesquisa de natureza qualitativa, caracterizada como pesquisa documental, de caráter bibliográfico, do tipo “estado da arte”. Em relação à dimensão dos conhecimentos os resultados indicam como temáticas mais abordadas: água, fauna, flora, poluição e resíduos sólidos. A proposta de desenvolver o trabalho por meio de projetos pedagógicos é relatada em onze dos treze trabalhos, mas algumas práticas revelam a ausência de participação das crianças nas decisões sobre o planejamento e a execução desses projetos, o que nos leva a questionar a compreensão desses professores sobre o trabalho por meio de projetos pedagógicos e sobre a construção de conhecimentos pelas crianças. No que se refere à dimensão de valores éticos e estéticos identificamos, por parte dos professores cujas práticas são investigadas, a intenção de formar valores envolvendo: a cooperação, a solidariedade, a autonomia, a sensibilidade, o respeito às diferenças, a afetividade e o cuidado. Práticas pedagógicas que contemplam a dimensão da participação política são relatadas em onze dos treze trabalhos e se efetivam, com mais frequência, no nível individual e no social. As pesquisas indicam a necessidade de uma teoria pedagógica que se alinhe à Educação Ambiental Crítica e ajude o professor a pensar e tomar decisões sobre sua prática.
O conceito de ecossistema como delimitação espaçotemporal nas pesquisas em educação ambiental: implicações para o ensino de ciências/biologia
Authors: Kato Danilo Seithi , Kawasaki Clarice Sumi , De Carvalho Luiz Marcelo 
Published: December 2020

O presente artigo origina-se de uma tese de doutoramento que teve como objetivo investigar o conceito de ecossistema presente em teses e dissertações em Educação Ambiental (EA), explorando os seus vários sentidos e significados, presentes em seu campo de origem - a Ecologia, e em suas ressignificações a partir e para além dele. Essa pesquisa, que se insere na perspectiva das investigações na linha do estado da arte da produção de conhecimento em uma dada área, analisou teses e dissertações em EA produzidas no Brasil, no período de 1980 a 2009. A partir da caracterização dessas pesquisas, procurou-se, inicialmente, identificar os principais indicadores resultantes das análises, na tentativa de explorar significados e sentidos sobre o conceito de ecossistema. Para este artigo, em particular, temos como objetivo a discussão dos possíveis significados e sentidos que temos construído sobre aspectos da delimitação espaçotemporal de um ecossistema, e suas implicações para o ensino de ciências/biologia. Os procedimentos metodológicos estão fundamentados na perspectiva da análise dialógica do discurso e inseridos no contexto da pesquisa qualitativa em educação. Os resultados mostraram sentidos divergentes e que são compreendidos a partir de perspectivas diversas sobre conceito de ecossistema, mesmo que estes não sejam enunciados diretamente. Assim, o resultado das análises evidencia esforços de aproximação com os significados originalmente empregados na Ecologia, em um sentido de validação do conhecimento científico produzido e trazendo, de forma mais tímida, elementos políticos e sociais que envolvem as questões ambientais. A partir dos dados analisados neste artigo, destacamos os possíveis desdobramentos, dos significados e sentidos apreendidos, para o discurso de ensino de conteúdos escolares da Ecologia em interface com as questões ambientais, no ensino das Ciências da Natureza. Esses significados possibilitam pensar a tendência das pesquisas em buscar a superação de sentidos contraditórios e dicotômicos encontrados nas pesquisas em EA, tais como, aqueles relacionados à: desenvolvimento sustentável ou sustentabilidade; equilíbrio ou harmonia; ser humano, cultura ou natureza, como possíveis posicionamentos ideológicos, e que são compreendidos a partir do conceito de ecossistema, mesmo que não sejam enunciados diretamente.
Immune Modulation of Allergic Asthma by Early Pharmacological Inhibition of RIP2
Authors: Miller Madelyn H , Shehat Michael G , Tigno-Aranjuez Justine T 
Published: December 2020

Abstract
Exposure to house dust mite (HDM) is highly associated with the development of allergic asthma. The adaptive immune response to HDM is largely Th2 and Th17 dominant, and a number of innate immune receptors have been identified that recognize HDM to initiate these responses. Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is a cytosolic sensor of peptidoglycan, which is important for Th2 and Th17 polarization. NOD2 mediates its signaling through its downstream effector kinase, receptor-interacting serine/threonine protein kinase 2 (RIP2). We have previously shown that RIP2 promotes HDM-associated allergic airway inflammation and Th2 and Th17 immunity, acting early in the HDM response and likely within airway epithelial cells. However, the consequences of inhibiting RIP2 during this critical period has not yet been examined. In this study, we pharmacologically inhibited RIP2 activity during the initial exposure to allergen in an acute HDM model of asthma and determined the effect on the subsequent development of allergic airway disease. We show that early inhibition of RIP2 was sufficient to reduce lung histopathology and local airway inflammation while reducing the Th2 immune response. Using a chronic HDM asthma model, we demonstrate that inhibition of RIP2, despite attenuating airway inflammation and airway remodeling, was insufficient to reduce airway hyperresponsiveness. These data demonstrate the potential of pharmacological targeting of this kinase in asthma and support further development and optimization of RIP2-targeted therapies.
Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4+ Th1 Cell Response
Authors: Ikeogu Nnamdi M , Edechi Chidalu A , Akaluka Gloria N , Feiz-Barazandeh Aida , Zayats Romaniya R , Salako Enitan S , Onwah Somtochukwu S , Onyilagha Chukuwunonso , Jia Ping , Mou Zhirong , Shan Lianyu , Murooka Thomas T , Gounni Abdelilah S , Uzonna Jude E 
Published: December 2020

Abstract
Protective immunity to cutaneous leishmaniasis is mediated by IFN-γ–secreting CD4+ Th1 cells. IFN-γ binds to its receptor on Leishmania-infected macrophages, resulting in their activation, production of NO, and subsequent destruction of parasites. This study investigated the role of Semaphorin 3E (Sema3E) in host immunity to Leishmania major infection in mice. We observed a significant increase in Sema3E expression at the infection site at different timepoints following L. major infection. Sema3E-deficient (Sema3E knockout [KO]) mice were highly resistant to L. major infection, as evidenced by significantly (p &lt; 0.05–0.01) reduced lesion sizes and lower parasite burdens at different times postinfection when compared with their infected wild-type counterpart mice. The enhanced resistance of Sema3E KO mice was associated with significantly (p &lt; 0.05) increased IFN-γ production by CD4+ T cells. CD11c+ cells from Sema3E KO mice displayed increased expression of costimulatory molecules and IL-12p40 production following L. major infection and were more efficient at inducing the differentiation of Leishmania-specific CD4+ T cells to Th1 cells than their wild-type counterpart cells. Furthermore, purified CD4+ T cells from Sema3E KO mice showed increased propensity to differentiate into Th1 cells in vitro, and this was significantly inhibited by the addition of recombinant Sema3E in vitro. These findings collectively show that Sema3E is a negative regulator of protective CD4+ Th1 immunity in mice infected with L. major and suggest that its neutralization may be a potential therapeutic option for treating individuals suffering from cutaneous leishmaniasis.
MAP3K8 Regulates Cox-2–Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis
Authors: Zannikou Markella , Barbayianni Ilianna , Fanidis Dionysios , Grigorakaki Theodora , Vlachopoulou Evlalia , Konstantopoulos Dimitris , Fousteri Maria , Nikitopoulou Ioanna , Kotanidou Anastasia , Kaffe Eleanna , Aidinis Vassilis 
Published: December 2020

Abstract
Idiopathic pulmonary fibrosis (IPF) is characterized by exuberant deposition of extracellular matrix components, leading to the deterioration of lung architecture and respiratory functions. Profibrotic mechanisms are controlled by multiple regulatory molecules, including MAPKs, in turn regulated by multiple phosphorylation cascades. MAP3K8 is an MAPK kinase kinase suggested to pleiotropically regulate multiple pathogenic pathways in the context of inflammation and cancer; however, a possible role in the pathogenesis of IPF has not been investigated. In this report, MAP3K8 mRNA levels were found decreased in the lungs of IPF patients and of mice upon bleomycin-induced pulmonary fibrosis. Ubiquitous genetic deletion of Map3k8 in mice exacerbated the modeled disease, whereas bone marrow transfer experiments indicated that although MAP3K8 regulatory functions are active in both hematopoietic and nonhematopoietic cells, Map3k8 in hematopoietic cells has a more dominant role. Macrophage-specific deletion of Map3k8 was further found to be sufficient for disease exacerbation thus confirming a major role for macrophages in pulmonary fibrotic responses and suggesting a main role for Map3k8 in the homeostasis of their effector functions in the lung. Map3k8 deficiency was further shown to be associated with decreased Cox-2 expression, followed by a decrease in PGE2 production in the lung; accordingly, exogenous administration of PGE2 reduced inflammation and reversed the exacerbated fibrotic profile of Map3k8 −/− mice. Therefore, MAP3K8 has a central role in the regulation of inflammatory responses and Cox-2–mediated PGE2 production in the lung, and the attenuation of its expression is integral to pulmonary fibrosis development.
Pliocene expansion of C4 vegetation in the Core Monsoon Zone on the Indian Peninsula
Authors: Dunlea Ann G. , Giosan Liviu , Huang Yongsong 
Published: December 2020

Abstract. The expansion of C4 vegetation during the Neogene
was one of the largest reorganizations of Earth's terrestrial biome. Once
thought to be globally synchronous in the late Miocene, site-specific
studies have revealed differences in the timing of the expansion and suggest
that local conditions play a substantial role. Here, we examine the
expansion of C4 vegetation on the Indian Peninsula since the late
Miocene by constructing a ∼6-million-year paleorecord with
marine sediment from the Bay of Bengal at Site U1445, drilled during
International Ocean Discovery Program Expedition 353. Analyses of element
concentrations indicate that the marine sediment originates from the Mahanadi
River in the Core Monsoon Zone (CMZ) of the Indian Peninsula. Hydrogen
isotopes of the fatty acids of leaf waxes reveal an overall decrease in the
CMZ precipitation since the late Miocene. Carbon isotopes of the leaf wax
fatty acids suggest C4 vegetation on the Indian Peninsula existed
before the end of the Miocene but expanded to even higher abundances during
the mid-Pliocene to mid-Pleistocene (∼3.5 to 1.5 million years ago). Similar to the CMZ on the Indian Peninsula, a Pliocene expansion or re-expansion has previously been observed in northwest Australia and in East Africa, suggesting that these tropical ecosystems surrounding the
Indian Ocean remained highly sensitive to changes in hydroclimate after the initial spread of C4 plants in late Miocene.
Towards Innovative and Sustainable Construction of Architectural Structures by Employing Self-Consolidating Concrete Reinforced with Polypropylene Fibers
Authors: Zatar Wael , Nguyen Hai 
Published: December 2020

Self-consolidating concrete (SCC) has been successfully employed to reduce construction time and enhance the quality, performance, and esthetic appearance of concrete structures. This research aimed at developing environmentally friendly fiber-reinforced concrete (FRC) consisting of SCC and recycled polypropylene (PP) fibers for sustainable construction of city buildings and transportation infrastructure. The addition of the PP fibers to SCC helps reducing shrinkage cracks and providing enhanced mechanical properties, durability, and ductility of the concrete materials. Several mix designs of self-consolidating fiber-reinforced concrete (SCFRC) were experimentally examined. Material and esthetic properties of the SCFRC mixtures that include micro silica, fly ash, and PP fibers were evaluated. Trial-and-adjustment method was employed to obtain practically optimum SCFRC mixtures, mixtures that are affordable and easy to make possessing enhanced compressive strength and esthetic properties. Slump flow and air content testing methods were used to determine the fresh properties of the SCFRC mixtures, and the esthetic properties of the mixtures were also evaluated. The hardened properties of the SCFRC mixtures were examined using three- and seven-day compression tests. The amount of fine/coarse aggregate, water, and other admixtures were varied while the Portland cement content in all mixtures was maintained unchanged. The maximum three-day compressive strength was 43.17 MPa and the largest slump flow was 736.6 mm. Test results showed enhanced material properties such as slump flow, air content and compressive strength values of the SCFRC mixtures and their excellent esthetic appearance. The favorable seven-day compressive strength of the SCFRC mixture, with 4.8 percent air content and 660.4 mm slump flow, is 39.26 MPa. The mixtures’ in this study are proven to be advantageous for potential SCFRC applications in architectural structures including building façades and esthetically-pleasing bridges.
The entrepreneurial orientation of women entrepreneurs in the Guadalajara Metropolitan Area as a path to sustainability
Authors: Navarrete-Baez Francisco , Orozco Patricia , Virchez Jorge 
Published: December 2020

This work shows the results obtained on a study done to women entrepreneurs of SME located in the Metropolitan Zone of Guadalajara (ZMG), Mexico, with respect to the systematization of business practices oriented to Entrepreneurial Orientation (EO). The theoretical basis was the Business Women, focused at Latin America, the SME behavior in Mexico, and in this way to understand, through these, if they are aimed at business sustainability. The methodology used was a quantitative analysis through to apply a survey of own development to the business women owning of the one SME in the ZMG. The sample was of 48 questionnaires, which included the profile of the businesswoman, and where 33 sustainable development practices. The results obtained through descriptive and inferential statistical analysis. The findings were found that the sustainable development practices developed are not adequate, and that the EO practices that they should have, are below what is desired, showing there are some disadvantages in these practices so that the sustainability of these companies are at risk.
Kinetic of Biogas Production in a Batch Anaerobic Digestion Process with Interference of Preservative Material of Sodium Benzoate
Authors: Sumantri Indro , Hadiyanto Hadiyanto 
Published: December 2020

Sodium benzoate is a preservative compounds which are widely used for both food and beverage products. The treatment of waste water containing this compound was normally conducted in a anaerobic digestion (AD) using a batch reactor system at a room temperature. The anaerobic process eventually produced biogas which can be used for bioenergy. This research was aimed to evaluate the production of biogas from by synthetic solution models containing sodium benzoate (SB). The experiment was performed in a variation of Mixed Liquor Suspended Solid (MLSS) of 4.8 and 7.2 g/L, and initial sodium benzoate concentration of 400, 600, and 800 mg/L. The digestion was performed at 60 days, while the biogas content was measured every 2 days. The results indicated a reduction in the cumulative biogas by the addition of sodium benzoate, compared to the control condition. Moreover, the decrease in organic loading rate (OLR) of SB in wastewater follows the first order kinetic with kinetic rate constant (k) was 0.0432 to 0.1254 (day−1) for MLSS of 4.8 g/L and 0.0276 to 0.0372 (day−1) for 7.2 g/L MLSS. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Corrigendum to: Enhanced Long-term Stability and Carbon Resistance of Ni/MnxOy-Al2O3 Catalyst in Near-equilibrium CO2 Reforming of Methane for Syngas Production [15(2), 2020, 331-347]
Authors: Djebarri Baya , Touahra Fouzia , Aider Nadia , Bali Ferroudja , Sehailia Moussa , Chebout Redouane , Bachari Khaldoun , Halliche Djamila 
Published: December 2020

According to Authors request (10th December 2020), Corrigendum to: Djebarri, B., Touahra, F., Aider, N., Bali, F., Sehailia, M., Chebout, R., Bachari, K., Halliche, D. (2020). Bulletin of Chemical Reaction Engineering & Catalysis, 15(2), 2020, 331-347 (doi:10.9767/bcrec.15.2.6983.331-347). First Author (Baya Djebarri) is added as member of Corresponding Author because of his largest contribution in the article and his expertise.Correction:The Authors Names were corrected to:Baya Djebarri1,*, Fouzia Touahra2,*, Nadia Aider4, Ferroudja Bali3, Moussa Sehailia2, Redouane Chebout2, Khaldoun Bachari2, Djamila Halliche3 The information detail of Corresponding Authors was corrected to:* Corresponding Authors. Email: tfafaze256@yahoo.fr (F. Touahra); b.djebarri@univ-boumerdes.dz (B. Djebarri)Copyright © 2020 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Design of a virtual longitudinal observational study in Parkinson’s disease (AT‐HOME PD)
Authors: Schneider Ruth B. , Omberg Larsson , Macklin Eric A. , Daeschler Margaret , Bataille Lauren , Anthwal Shalini , Myers Taylor L. , Baloga Elizabeth , Duquette Sidney , Snyder Phil , Amodeo Katherine , Tarolli Christopher G , Adams Jamie L. , Callahan Katherine F , Gottesman Joshua , Kopil Catherine M. , Lungu Codrin , Ascherio Alberto , Beck James C. , Biglan Kevin , Espay Alberto J. , Tanner Caroline , Oakes David , Shoulson Ira , Novak Dan , Kayson Elise , Ray Dorsey Earl , Mangravite Lara , Schwarzschild Michael A. , Simuni Tanya ,   the Parkinson Study Group AT‐HOME PD Investigators
Published: December 2020

AbstractObjectiveThe expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site‐centric therapeutic trials in Parkinson’s disease and generate novel insights. The value of this approach has never been more evident than during the current COVID‐19 pandemic. We sought to (1) establish and implement the infrastructure for longitudinal, virtual follow‐up of clinical trial participants, (2) compare changes in smartphone‐based assessments, online patient‐reported outcomes, and remote expert assessments, and (3) explore novel digital markers of Parkinson’s disease disability and progression.MethodsParticipants from two recently completed phase III clinical trials of inosine and isradipine enrolled in Assessing Tele‐Health Outcomes in Multiyear Extensions of Parkinson’s Disease trials (AT‐HOME PD), a two‐year virtual cohort study. After providing electronic informed consent, individuals complete annual video visits with a movement disorder specialist, smartphone‐based assessments of motor function and socialization, and patient‐reported outcomes online.ResultsFrom the two clinical trials, 226 individuals from 42 states in the United States and Canada enrolled. Of these, 181 (80%) have successfully downloaded the study’s smartphone application and 161 (71%) have completed patient‐reported outcomes on the online platform.InterpretationIt is feasible to conduct a large‐scale, international virtual observational study following the completion of participation in brick‐and‐mortar clinical trials in Parkinson’s disease. This study, which brings research to participants, will compare established clinical endpoints with novel digital biomarkers and thereby inform the longitudinal follow‐up of clinical trial participants and design of future clinical trials.
Ring‐Closing Olefin Metathesis Catalyzed by Well‐Defined Vanadium Alkylidene Complexes
Authors: Belov Dmitry S. , Tejeda Gabriela , Tsay Charlene , Bukhryakov Konstantin V. 
Published: December 2020

AbstractVanadium‐based catalysts have shown activity and selectivity in ring‐opening metathesis polymerization of strained cyclic olefins comparable to those of Ru, Mo, and W catalysts. However, the application of V alkylidenes in routine organic synthesis is limited. Here, we present the first example of ring‐closing olefin metathesis catalyzed by well‐defined V chloride alkylidene phosphine complexes. The developed catalysts exhibit tolerance to various functional groups, such as an ether, an ester, a tertiary amide, a tertiary amine, and a sulfonamide. The size and electron‐donating properties of the imido group and the phosphine play a crucial role in the stability of active intermediates. Reactions with ethylene and olefins suggest that both β‐hydride elimination of the metallacyclobutene and bimolecular decomposition are responsible for catalyst degradation.