bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Different Drugs in Treating Urinary Schistosomiasis: Systematic Review and Network Meta-analysis
Authors: Fang Huilong , Guo Xuli , Tang Chuwei , Chen Fuchun , Badr Ahmed , Luo Feng , Wang Junjie 
Published: May 2020

Abstract
Background Praziquantel is the current pillar for morbidity control of schistosomiasis. Artesunate and its derivatives, widely used for malaria treatment, also display antischistosomal activities. This review compares the efficacy of three drugs, namely praziquantel (PZQ), artesunate, and metrifonate in urinary schistosomiasis. Methods Databases were searched for articles comparing the effectiveness of any of the three drugs to other medications or controls in urinary schistosomiasis in children aged 18 or less. Stata software was opted to generate the network meta-analysis. Efficacy (Cure rate and egg reduction rate) was the main outcome measure. Pairwise and network meta-analysis were used to report Odds Ratios (ORs) with either 95% confidence interval (CI) for direct comparisons or 95% credible intervals (CrI) for indirect comparisons. Results The SUCRA plot for cure rate revealed that PZQ (SUCRA= 40.4%) was the fourth effective drug after albendazole 400mg (SUCRA= 71.5), metrifonate 5 mg (SUCRA= 62.2%), and metrifonate 10 mg (SUCRA= 59.7). PZQ was only superior to metrifonate 7.5 mg. ORs were PZQ 40 mg (OR 0.48; 95% CI -3.55 to 4.51; p-value 0.816), artesunate 6 mg (OR 0.06; 95% CI -5.67 to 5.79; p-value 0.983), metrifonate 5 mg (OR -1.65; 95% CI -7.52 to 4.21; p-value 0.581), metrifonate 10 mg (OR -1.76; 95% CI -8.86 to 5.34; p-value 0.628), and metrifonate 7.5 mg (OR -2.40; 95% CI -9.78 to 4.98; p-value 0.524). A similar plot for egg reduction rate showed an exclusive superiority of PZQ 40 mg (SUCRA= 94.4%), followed by metrifonate 10mg (SUCRA= 82.3%) and niridazole 25mg plus metrifonate 10mg (SUCRA= 48.6%). Conclusions Our network analysis revealed that PZQ 40 mg was the most efficient drug in reducing egg count, whereas albendazole 400mg showed the highest cure rates.
Reasons for not achieving control: therapeutic inertia in monitoring hypertension in primary care.
Authors: Robert Arleen De León , López-Alegría Carmen , Hidalgo-García Isabel María , Escribano-Sabater María Concepción , Antón-Botella José Joaquin , Perez-Cabrera Yoalys Dilvani , Gascón-Cánovas Juan José 
Published: May 2020

Abstract
Background: Physicians’ failure to change/adjust treatments after learning of poor follow-up control in hypertensive patients can be defined as clinical inertia, a frequent and serious problem that affects health care activity at the international level. Method: A total of 153 hypertensive patients under 80 years of age who met the inclusion and exclusion criteria and had received ambulatory blood pressure monitoring (ABPM) for 24 hours as the follow-up method to evaluate their level of blood pressure (BP) control. One year after data collection, the included patients were studied retrospectively, and the changes introduced by their physicians were checked based on their results. Results: Sixty-five hypertensive patients (42.5%) out of the total sample (153) were classified as poorly controlled; of these, 36 were subject to therapeutic inertia (55%). Of the 29 hypertensive patients who did undergo treatment adjustment (45%), 15 (52%) underwent adjustment before the month of notification. Conclusion: Therapeutic inertia in the care of hypertensive patients continues to be a common problem in primary care. Young hypertensive patients of male sex, smokers and nondiabetic patients were the most affected groups. Test record: Registered retrospectively by the Clinical Ethics Committee of the José María Morales Meseguer University Hospital with the code EST: 62/17
Clinical and prognostic significance of PMN in children with glomerular C1q deposition
Authors: Wang Ren , Wang Meiqiu , Xia Zhengkun , Gao Chunlin , Shi Zhuo , Fang Xiang , Wu Heyan , Peng Yingchao 
Published: May 2020

Abstract
Background

Currently, studies to data in MN are consistent with complement activation has an essential role in mediating renal injury, and the LP is considered to be the principal pathway in PMN. CP activation initiated by C1q which deposits are suggestive of SMN. However, C1q deposition together with IgG and C3 granular deposit is found in many cases of PMN. Currently, the clinical and prognostic significance of C1q deposition in PMN is unclear. Therefore, we conduct this single-center research to explore the clinical and prognostic significance of C1q deposition in children with PMN.
Method:

73 patients with C1q deposition were enrolled in this study. According to the “Case-control matching principle”, 73 patients without C1q deposition during the same period of the renal biopsy were selected as a control group. The clinical and pathological characteristics, treatment response, and long-term renal prognosis were compared between patients with and without C1q deposition.
Result

A total of 146 pediatric patients with PMN included with 86 men(58.9%) and 60 women (41.1%). The median age at onset was 15.0 (14.0—16.0) years. During an average follow-up of 52.4 ± 35.6 months, 8 patients (5.5%) progressed ESKD, 12 (8.2%) patients developed ESRD or renal dysfunction. The frequency of glomerular C4 deposits in the C1q deposits group was significantly higher than no C1q deposits group (34.2% vs 5.5%, p = 0.000). There were no other distinct differences in clinical and pathological characteristics between the two groups. Glomerular IgG subclasses were available in 79 patients, there was no difference in the glomerular IgG subclass distribution between the two groups (p IgG1=0.468,p IgG2=1.000༌p IgG3=0.988༌p IgG4=0.216). The Kaplan-Meier survival analysis found that there was no difference in the renal survival of ESRD (p = 0.415) and a combined event of ESRD and/or renal dysfunction (p = 0.214) between the two groups. The logistic regression analysis (p = 0.553) and Cox regression analysis (p = 0.618) revealed that C1q deposition failed to associate with renal dysfunction.
Conclusion

The CP does occur in some patients of PMN. However, it may be unrelated to the progression of the disease.
External Versus Endoscopic Dacryocystorhinostomy for Recurrent Dacryocystitis after Endoscopic Dacryocystorhinostomy
Authors: Zhang Haitao , Shen Shuhao , Yang Jiajun , Xu Zhe 
Published: May 2020

Abstract
Purpose

The aim of this study was to retrospectively compare the clinical effects of external dacryocystorhinostomy (EX-DCR) and endoscopic dacryocystorhinostomy (EN-DCR) on recurrent dacryocystitis after EN-DCR.
Methods

Thirty cases involving thirty eyes with post-EN-DCR recurrent dacryocystitis in our hospital between January 2015 and December 2018 were analyzed retrospectively. All of the patients underwent routine preoperative examination, including probing and irrigation of the lacrimal passage, nasal endoscopy, and maxilla-facial computed tomography scanning. Patients with nasal adhesions, nasal tumors and severe deviation of the nasal septum were excluded. Under general anesthesia, twelve patients underwent EN-DCR, and eighteen patients experienced EX-DCR under general anesthesia. Anti-inflammatory treatment was carried out after surgery for one week. The medical records of all the patients were tracked for one year.
Results

At the third month, all of the EN-DCR patients achieved good results with unobstructed lacrimal irrigation after removal of the bicanalicular tube stents. Sixteen EX-DCR patients had patency of the lacrimal passage, while two other patients exhibited obstructed lacrimal passage. However, at the twelfth month, ten EN-DCR patients had an obstructed lacrimal passage again, and there were only two patients remaining patency in lacrimal duct with a (success rate of 16.7%). In contrast, among the eighteen EX-DCR patients, fifteen cases achieved success with smooth irrigation of the lacrimal passage with a (success rate of 83.3%). There was a statistically significant difference between the two groups in the success rate for the longer follow-up period. No major intra- or post -treatment complications occurred.
Conclusions

EX-DCR is effective and safe with a higher success rate for the treatment of recurrent dacryocystitis after EN-DCR and might be considered as a primary compensate therapy for EN-DCR.
MicroRNA-532 inhibits cell growth and metastasis in retinoblastoma by targeting MDM4
Authors: Li Changfei , Niu Yufen , Wang Congcong , Jia Ting , Ren Qingxia , Xu Jing 
Published: May 2020

Abstract
Background

Now, numerous microRNAs (miRNAs) are found to exert effect in retinoblastoma (RB). This research mainly focused on the function of miR-532 in RB, which has not been investigated.
Methods

RT-qPCR and Western blot analysis were used to measure expressions of miR-532 and genes. Transwell, CCK-8 and luciferase reporter assays were applied to explore functions of miR-532 and MDM4 in RB.
Results

The expression of miR-532 was reduced in RB. Furthermore, overexpression of miR-532 restrained RB cell survival and metastasis and induced apoptosis. In addition, miR-532 directly targets MDM4. Moreover, downregulation of MDM4 blocked the progression of RB. And upregulation of MDM4 reversed the anti-tumor effect of miR-532 in RB.
Conclusion

MiR-532 inhibited cell viability and metastasis in RB by targeting MDM4, indicating that miR-532 may be a novel therapeutic target for RB patients.
The Burden of Liver Cirrhosis and Underlying Etiologies: Results from the Global Burden of Disease Study 2017
Authors: Zhai Mimi , Long Jianhai , Liu Sushun , Liu Chun , Li Li , Yang Leping , Li Yamin , Shu Bo 
Published: May 2020

Abstract
Background

Liver cirrhosis is a major health issue worldwide. Few studies have explored the prevalence trends caused by specific etiologies. This study was conducted to evaluate the pattern and prevalence trends.
Methods

We collected detailed data on liver cirrhosis based on GBD 2017 study. The ASR and EAPC were used to estimate the trends in prevalence by population, etiology and region.
Results

Globally, the number of prevalent cases increased 74.53% from 1990 to 2017. The worldwide ASR increased 0.75 per year. The increasing pattern was heterogeneous. The most pronounced increases were found in middle-high and high SDI regions, especially in the Caribbean, Andean Latin America and Southern Latin America. Among the etiologies, NASH-related liver cirrhosis accounted for 59.46% of the cases in 2017. The ASR increased 1.74 per year, and the increase was observed in all 5 SDI regions. In addition, the ASR of liver cirrhosis caused by alcohol use also increased in both sexes and all 5 SDI regions. In contrast, the ASR of liver cirrhosis caused by HBV and HCV decreased, especially in the middle and low-middle SDI regions.
Conclusions

By using vaccine and direct-acting antiviral therapy, the number of people suffering from HBV and HCV decreased, but liver cirrhosis was still a major threat to human health. Additionally, the number of people with cirrhosis caused by alcohol and NASH continued to grow. Thus, more targeted and specific strategies should be established in countries based on the etiology and prevalence trends for liver cirrhosis.
Duct-to-mucosa pancreaticojejunostomy can reduce the risk of pancreatic fistula after pancreaticoduodenectomy
Authors: Ma Li-bin , Wang Xingcheng , Li Qiang , Chai Chen 
Published: May 2020

Abstract
Background: Pancreaticoduodenectomy (PD) is the most effective surgical procedure to remove a pancreatic tumor. However, pancreatic fistula occurring after surgery is associated with a high incidence of life-threatening complications. Therefore, the aim of this work was to summarize the factors influencing the development of pancreatic fistula after PD and the measures to prevent it. Methods: Clinical data of patients who were subjected to PD between January 2012 and January 2017 in the Department of General Surgery, First Hospital of Lanzhou University, China, were collected and retrospectively analyzed. The risk factors for pancreatic fistula were analyzed by univariate analysis and multivariate logistic regression analysis. Results: Among 215 patients, 42 were suffering from a postoperative pancreatic leakage, with an incidence of 19.5% (42/215). Univariate analysis showed a significant correlation between postoperative pancreatic fistula (POPF) and the following factors: pancreaticojejunal anastomosis (end-to-side “sleeve” pancreaticojejunostomy vs duct-to-mucosa pancreaticojejunostomy: 27.8% vs 11.2%, P = 0.002), pancreatic duct diameter (≤ 3 mm vs > 3 mm: 25.2% vs 13.8%, P = 0.036), and pancreatic texture (hard vs soft: 14.2% vs 25.2%, P = 0.043). Multivariate logistic regression analysis showed that pancreaticojejunal anastomosis was the independent risk factor for POPF after PD. Conclusions: High quality anastomosis is an important factor in the prevention of POPF. Pancreaticojejunal duct-to-mucosa anastomosis is a simple technique and results in a low incidence of pancreatic fistula.
PD-1/PD-L1 axis suppressed homeostatic proliferation–driven antitumor immunity during recovery from lymphopenic condition.
Authors: Yang Zike , Liu Yanyouhong , Chen Zehong , Lai Nan , Luo Rongcheng , Kang Shijun 
Published: May 2020

Abstract
Background Lymphopenic condition after radiotherapy or chemotherapy might be able to create an environment to mount an efficient antitumor immunity through the homeostatic proliferation of residual or adoptive lymphocytes. However, the antitumor immunity seems to decrease rapidly with the growth of tumor, and the mechanism remain elusive. Methods In this study, we first examined the dynamic change of PD-1 expression on T cells and analyzed the connection between PD-1 expression and the exhaustion of CTLs when the number of T cells recovered from lymphopenic conditions. Anti-PD-1/PD-L1 therapies, including anti-PD-1 antibodies, PD-1 or PD-L1 knockout by Crispr-Cas9 system, were used in the study to evaluate the role of PD-1/PD-L1 block on the antigen recognition, differentiation, activation, killing, survival and prognosis of HP cells. Results Our study found that in the mouse model of homeostatic proliferation, although T cells proliferated continuously in lymphopenic host, the number of IFN-γ-releasing CD8+T cells rapidly decreased in course of homeostatic proliferation, indicating the immunosuppressive state in tumor microenvironment. The expression of PD-1 on T cells, increased gradually in course of homeostatic proliferation, were significantly negatively related to the cytotoxicity of effector T cell. Blocking of PD-1/PD-L1 axis by PD-1 antibody promoted HP cells to recognize tumor associated antigen (TAAs) and resulted in the activation of DC cells. It can also enhanced the number of IFN-γ-releasing CD8+ T cells and the cytotoxicity of effector T cell in lymphopenic mice. Furthermore, PD-1 antibody induced a portion of tumor-specific CTL convert to central memory T cells (TCM). Finally, we found that Crispr/Cas9-mediated knockout of PD-1 in T cells or PD-L1 in melanoma cells significantly enhanced homeostatic proliferation–driven antitumor responses and inhibited tumor growth. Conclusion These findings suggested PD-1/PD-L1 played an important role in the formation of immune tolerance during the period of homeostatic proliferation. Anti-PD-1/PD-L1 therapies may be used to enhance antitumor immunity during recovery from lymphopenic condition after chemotherapy or radiotherapy.
Graphene oxide-silver nanoparticle nanocomposites induces apoptosis in caprine fetal fibroblast cells via induction of oxidative stress
Authors: Yuan Yu-Guo , Joo Myeong-Don , Wang Jia-Lin , Mesalam Ayman , R Abu Musa Md Talimur , Wang Yi , Qian Chen , Kong Il-Keun 
Published: May 2020

Abstract
Background: Graphene oxide (GO) has drawn much attention as excellent platform to which silver nanoparticles (AgNPs) can be anchored for the production of biomedical nanocomposites. Yet, the potential toxicity of GO-AgNPs nanocomposites to animal and human is complex to evaluate and remains largely unknown. Results: Our data indicated that GO-AgNPs caused cytotoxicity in dose-dependent manner. GO-AgNPs induced significant cytotoxicity by the loss of cell viability, production of reactive oxygen species (ROS), cell cycle arrest, increasing leakage of lactate dehydrogenase (LDH) and level of Malondialdehyde (MDA), increasing expression of pro-apoptotic genes and decreasing expression of anti-apoptotic genes. Conclusions: Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. It strongly suggests that applications of GO-AgNPs nanocomposite in animal must be further evaluated.
Knowledge, perceptions and preventive practices towards COVID-19 among Jimma University Medical Center visitors, Southwest Ethiopia
Authors: Kebede Yohannes , Yitayih Yimenu , Birhanu Zewdie , Mekonen Seblework , Ambelu Argaw 
Published: May 2020

Abstract
Background: The novel-coronavirus disease-2019 (COVID-19) is currently a pandemic and public health emergency of international concern, as avowed by the World Health Organization (WHO). Ethiopia has become one of the affected countries as of March 15, 2020.Objective: This study aimed to assess the knowledge, perceptions, and practices among Jimma University medical center (JUMC) visitors in Jimma town.Methods: A cross-sectional study was conducted on 247 sampled visitors, from 20-24 March, 2020. Consecutive sampling was used to recruit participants. The study tools were adapted from WHO resources. The data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Descriptive statistics was used to describe the status of knowledge, perception and practices. Logistic regression was executed to assess predictors of dominant preventive practices.Results: of the 247 respondents, 205 (83.0%) knew the main clinical symptoms of COVID-19. 72.0% knew that older people who have chronic illnesses are at high risk of developing a severe form of COVID-19. About 95.1% knew that COVID-19 virus spreads via respiratory droplets of infected people while 77 (31.2%) of the respondents knew about the possibility of asymptomatic transmission. Only 15 (6.1%) knew that children and young adults have to involve preventive measures. Overall, 41.3% of the visitors had high knowledge.The majority, 170(68.8%), felt self-efficacious to control COVID-19. 207(83.3%) believed that COVID-19 is a stigmatized disease. Frequent hand washing (77.3%) and avoidance of shaking hands (53.8%) the were dominant practices. Knowledge status and self-efficacy (positively), older ages and unemployment (negatively) predicted hand washing and avoidance of handshaking.Conclusions: The status of knowledge and desirable practices were not sufficient enough to combat this rapidly spreading virus. COVID-19 risk communication and public education efforts should focus on building appropriate level of knowledge while enhancing adoption of recommended self-care practices with special emphasize on high-risk audience segments.
GOD AND COSMOS AS REALITY: An Inquiry to the Interconnection among Islamic Philosophical Doctrine
Authors: Zarkasyi Hamid Fahmy , Arroisi Jarman , Salim Mohammad Syam’un , Taqiyuddin Muhammad 
Published: May 2020

In the Islamic intellectual tradition, Being (wujūd) is not limited to physical things. God is also understood as Being; indeed, He is the Absolute Being itself; which of Him, manifests all metaphysical and physical realities. This physical nature is one of the realities caused by God; as well as the metaphysical reality of 'natural law' called 'sunnatullāh' in Islam. It is necessary to know how the power of God can connect to this universe. The question presupposes cosmological research, which needs to involve the study of God and His attributes as well. Methodologically, the verification of Islamic philosophical ideas among Muslim philosophers to Sufis, involves the development of the key concept from tafsīr and ta'wīl among the Quranic verses (āyat) that discuss God's relationship with Nature itself; from this framework, the relationship between the two can be explained. This article, offers a study of the views of Muslim thinkers: from philosophers to Sufis, about the relationship; which specifically highlights that God and Nature are part of the concept of 'reality' in the Islamic view. The study concludes several important things, especially that God is the Absolute Being; which from Him, another reality as the sign (āyat) of His Existence created. His sunnatullāh again manifests in God’s creatures that undergo being devastated and recreated.
Mathematical Modelling to Assess the Impact of Lockdown on COVID-19 Transmission in India: Model Development and Validation
Authors: Ambikapathy Bakiya , Krishnamurthy Kamalanand 
Published: May 2020

Background
The World Health Organization has declared the novel coronavirus disease (COVID-19) to be a public health emergency; at present, India is facing a major threat of community spread. We developed a mathematical model for investigating and predicting the effects of lockdown on future COVID-19 cases with a specific focus on India.

Objective
The objective of this work was to develop and validate a mathematical model and to assess the impact of various lockdown scenarios on COVID-19 transmission in India.

Methods
A model consisting of a framework of ordinary differential equations was developed by incorporating the actual reported cases in 14 countries. After validation, the model was applied to predict COVID-19 transmission in India for different intervention scenarios in terms of lockdown for 4, 14, 21, 42, and 60 days. We also assessed the situations of enhanced exposure due to aggregation of individuals in transit stations and shopping malls before the lockdown.

Results
The developed model is efficient in predicting the number of COVID-19 cases compared to the actual reported cases in 14 countries. For India, the model predicted marked reductions in cases for the intervention periods of 14 and 21 days of lockdown and significant reduction for 42 days of lockdown. Such intervention exceeding 42 days does not result in measurable improvement. Finally, for the scenario of “panic shopping” or situations where there is a sudden increase in the factors leading to higher exposure to infection, the model predicted an exponential transmission, resulting in failure of the considered intervention strategy.

Conclusions
Implementation of a strict lockdown for a period of at least 21 days is expected to reduce the transmission of COVID-19. However, a further extension of up to 42 days is required to significantly reduce the transmission of COVID-19 in India. Any relaxation in the lockdown may lead to exponential transmission, resulting in a heavy burden on the health care system in the country.