bluuebunny/crossref_metadata_2025_split huggingface dataset:
A parapagus dicephalus tripus tribrachius conjoined twin with a unique morphological pattern: a case report
Authors: Bovendeert Jeske F. M. , Nievelstein Rutger A. J. , Bleys Ronald L. A. W. , Cleypool Cindy G. J. 
Published: October 2020

Abstract
Background
Conjoined twinning is a rare congenital malformation with an incidence of about 1.5 per 100,000 births. Because no consensus has been reached regarding the dysmorphology, thorough descriptions of conjoined twins as part of teratological collections can be useful to increase knowledge of this congenital malformation. In this case report, we describe a parapagus dicephalus twin from the collection of the Department of Anatomy of the University Medical Center Utrecht in the Netherlands. External anatomical characteristics were assessed through a detailed macroscopic examination and internal characteristics by means of whole-body computed tomography and magnetic resonance imaging (3 Tesla).

Case presentation
Macroscopic examination showed a Caucasian male parapagus dicephalus tripus tribrachius conjoined twin a type of conjoined twinning in which there are two heads side by side, one rump, and three upper and three lower limbs. In addition, anencephaly was observed in the left twin. Radiological imaging showed a normal central nervous system in the right twin and absence of the calvaria, cerebrum, diencephalon, and mesencephalon in the left twin. There was clear duplication of the vertebral column, rib cage, respiratory system, and gastrointestinal system at least up to and including the first part of the duodenum. The heart consisted of a monoatrium with two separate ventricles. There was a fused liver with a single gallbladder, a single spleen, three kidneys, two bladders, and duplication of the penis. The third upper and lower extremities were articulating with a fused glenoid and acetabulum, respectively. The third foot showed both polydactyly and syndactyly of the toes.

Conclusion
This case report describes a unique case of a male dicephalus parapagus tripus tribrachus conjoined twin discordant for anencephaly. Radiological imaging proved to be an adequate noninvasive method to provide insights into the internal (dys)morphology of this specific specimen, improving its scientific and educational value. This approach could be generally applied to other teratological specimens, thereby strengthening arguments regarding pathogenetic hypotheses, which may lead to new or improved insights into both normal and abnormal embryonic development.
Recurrence of lymphoma with isolated pericardial mass: a case report
Authors: Serin Istemi , Ulusoy Avni , Onar Mediha Irem , Dogu Mehmet Hilmi 
Published: October 2020

Abstract
Background
Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma and may occur with lymph node and/or extranodal involvement. Recurrence in patients with diffuse large B-cell lymphoma usually occurs within the first few years after treatment and may occur in a different area outside the initial localization.

Case presentation
A female Turkish patient who was diagnosed with nodular sclerosing Hodgkin lymphoma through lymphadenopathy examination reached remission after chemotherapy and radiotherapy. In the 11th year of follow-up and at the age of 45, newly developed multiple lymphadenopathies were diagnosed with a pathological result of diffuse large B-cell lymphoma in her advanced examination. Due to massive splenomegaly and cystic necrotic splenic residues, splenectomy was performed after eight cycles of a first-line chemotherapy regimen and two cycles of high-dose methotrexate treatment for central nervous system prophylaxis. A pericardial mass (maximum standardized uptake value 34.8), which was not present at the time of diagnosis and interim evaluation of positron emission tomography/computed tomography, was detected through chest pain in the third month after the last screening, although a complete response had been obtained. Pathological examination of the pericardial area revealed the pathological result was a recurrence.

Conclusions
Patients with diffuse large B-cell lymphoma have an aggressive clinical course, but cardiac involvement is very rare. In our patient’s case, pericardial involvement was observed after treatment and scanning revealed that recurrence took place in an area different from the pericardium. Cooperation of clinicians and pathologists and rapid evaluation are very important in cases of diffuse large B-cell lymphoma relapse. Although a tumoral invasion of the pericardium mostly suggests secondary malignancies, it should be kept in mind that recurrence of lymphoma is also possible.
A novel thermostable alkaline histamine oxidase from Glutamicibacter sp. N1A3101, induced by histamine and its analogue betahistine
Authors: Sadeghi Hossein , Arjmand Sareh , Ranaei Siadat Seyed Omid , Fooladi Jamshid , Ebrahimipour Gholamhossein 
Published: October 2020

Abstract
Biogenic amines (BAs) are low molecular weight organic bases formed by natural amino acids decarboxylation and trigger an array of toxicological effects in humans and animals. Bacterial amine oxidases enzymes are determined as practical tools to implement the rapid quantification of BAs in foods. Our study set out to obtain a new efficient, amine oxidase enzyme for developing new enzyme-based quantification of histamine. The soils from different sources were screened using histamine as sole carbon and nitrogen sources, and histamine oxidase producing bacteria were selected and identified using specific primers for histamine oxidase (HOD) gene. The HOD gene of six strains, out of 26 isolated histamine-utilizing bacteria, were amplified using our designed primers. The HOD enzyme from Glutamicibacter sp. N1A3101, isolated from nettle soil, was found to be thermostable and showed the highest substrate specificity toward the histamine and with no detected activity in the presence of putrescine, cadaverine, spermine, and spermidine. Its oxidation activity toward tyramine was lower than other HOD reported so far. The isolated enzyme was stable at 60 °C for 30 min and showed pH stability ranging from 6 to 9. Furthermore, we indicated the induction of identified HOD activity in the presence of betahistine as well, with nearly equal efficiency and without the consumption of the substrate.
New fractional approaches for n-polynomial P-convexity with applications in special function theory
Authors: Chen Shu-Bo , Rashid Saima , Noor Muhammad Aslam , Hammouch Zakia , Chu Yu-Ming 
Published: October 2020

AbstractInequality theory provides a significant mechanism for managing symmetrical aspects in real-life circumstances. The renowned distinguishing feature of integral inequalities and fractional calculus has a solid possibility to regulate continuous issues with high proficiency. This manuscript contributes to a captivating association of fractional calculus, special functions and convex functions. The authors develop a novel approach for investigating a new class of convex functions which is known as ann-polynomial$\mathcal{P}$P-convex function. Meanwhile, considering two identities via generalized fractional integrals, provide several generalizations of the Hermite–Hadamard and Ostrowski type inequalities by employing the better approaches of Hölder and power-mean inequalities. By this new strategy, using the concept ofn-polynomial$\mathcal{P}$P-convexity we can evaluate several other classes ofn-polynomial harmonically convex,n-polynomial convex, classical harmonically convex and classical convex functions as particular cases. In order to investigate the efficiency and supremacy of the suggested scheme regarding the fractional calculus, special functions andn-polynomial$\mathcal{P}$P-convexity, we present two applications for the modified Bessel function and$\mathfrak{q}$q-digamma function. Finally, these outcomes can evaluate the possible symmetric roles of the criterion that express the real phenomena of the problem.
β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice
Authors: Shi Hongli , Yu Yinghua , Lin Danhong , Zheng Peng , Zhang Peng , Hu Minmin , Wang Qiao , Pan Wei , Yang Xiaoying , Hu Tao , Li Qianqian , Tang Renxian , Zhou Feng , Zheng Kuiyang , Huang Xu-Feng 
Published: October 2020

Abstract
Background
“Western” style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low in fiber. This diet pattern is associated with a myriad of metabolic dysfunctions, including neuroinflammation and cognitive impairment. β-glucan, the major soluble fiber in oat and barley grains, is fermented in the lower gastrointestinal tract, potentially impacting the microbial ecosystem and thus may improve elements of cognition and brain function via the gut-brain axis. The present study aimed to evaluate the effect of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD).

Results
After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induced cognitive impairment assessed behaviorally by object location, novel object recognition, and nesting building tests. In the hippocampus, β-glucan countered the HFFD-induced microglia activation and its engulfment of synaptic puncta, and upregulation of proinflammatory cytokine (TNF-α, IL-1β, and IL-6) mRNA expression. Also, in the hippocampus, β-glucan significantly promoted PTP1B-IRS-pAKT-pGSK3β-pTau signaling for synaptogenesis, improved the synaptic ultrastructure examined by transmission electron microscopy, and increased both pre- and postsynaptic protein levels compared to the HFFD-treated group. In the colon, β-glucan reversed HFFD-induced gut barrier dysfunction increased the thickness of colonic mucus (Alcian blue and mucin-2 glycoprotein immunofluorescence staining), increased the levels of tight junction proteins occludin and zonula occludens-1, and attenuated bacterial endotoxin translocation. The HFFD resulted in microbiota alteration, effects abrogated by long-term β-glucan supplementation, with the β-glucan effects on Bacteroidetes and its lower taxa particularly striking. Importantly, the study of short-term β-glucan supplementation for 7 days demonstrated pronounced, rapid differentiating microbiota changes before the cognitive improvement, suggesting the possible causality of gut microbiota profile on cognition. In support, broad-spectrum antibiotic intervention abrogated β-glucan’s effects on improving cognition, highlighting the role of gut microbiota to mediate cognitive behavior.

Conclusion
This study provides the first evidence that β-glucan improves indices of cognition and brain function with major beneficial effects all along the gut microbiota-brain axis. Our data suggest that elevating consumption of β-glucan-rich foods is an easily implementable nutritional strategy to alleviate detrimental features of gut-brain dysregulation and prevent neurodegenerative diseases associated with Westernized dietary patterns.
Perovskite oxides as transparent semiconductors: a review
Authors: He Haiying , Yang Zhihao , Xu Yonghang , Smith Andrew T. , Yang Guangguang , Sun Luyi 
Published: October 2020

AbstractTraditional transparent conducting oxides (TCOs) have been widely used for various optoelectronic applications, but have the trade-off between conductivity and transmittance. Recently, perovskite oxides, with structural and chemical stability, have exhibited excellent physical properties as new TCOs. We focus on SrVO3-based perovskites with a high carrier concentration and BaSnO3-based perovskites with a high mobility for n-type TCOs. In addition, p-type perovskites are discussed, which can serve as potential future options to couple with n-type perovskites to design full perovskite based devices.
Unequal internationalisation and the emergence of a new epistemic community: gender and migration
Authors: Kofman Eleonore 
Published: October 2020

AbstractIn this contribution to the formation of an epistemic community and its knowledge production developed in the PaperBetween fragmentation and institutionalisation: the rise of migration studies as a research field, I seek to go beyond the bibliometric analysis, and in particular explore the nature of its internationalisation, the connections authors have across the globe and the unequal valuation of differently located research. These aspects underpin networks in the formation and evolution of epistemic communities. I shall illustrate my points through an epistemic community which has grown significantly in the past two decades, but scarcely gains a mention in the Paper. Gender and migration can be placed within the much broader cluster of globalisation, and especially in more recent years, transnationalism. My analysis does not start from bibliometric measures, which I do not have, but is based on selected reviews at different stages of the emergence of this field and my own involvement in it since the early 1990s.
A perspective on retina education through social media
Authors: Leitão Guerra Ricardo Luz 
Published: October 2020

AbstractSince the beginning of the Internet, new ways of providing medical education have emerged. Social media networks are one of the most influential communication tools and allow content sharing, collaborative modification and interaction. Its relevance for teaching and learning in medical education has been extensively studied. These new media have also heightened the need for a new way of communication. The purpose of this article is to discuss the value of communication in medical education through social media and present an eight-year personal experience on this field.
Internet page content analysis of north European Sea ports
Authors: Hilmola Olli-Pekka , Tolli Andres , Kiisler Ain 
Published: October 2020

AbstractThis study analyses 98 Internet pages of sea ports located in Sweden, Finland and Estonia during years 2017–2019. Aim of the study is to find, how website basic design is completed (colours and languages), how slogans, environmental issues, statistics and hinterland transports are reported. Based on the analysis, it appears as rather common that sea ports follow conservative selection of colours in their websites, where blue and white are clearly most popular. Typically, English and Swedish are as the most common used language, followed by Finnish, Russian and Estonian. In some rare cases, websites are offered in Chinese or German. Larger sea ports do have clear “slogans”, where smaller ones are just having lengthy justification for their existence. Environmental issues are increasing concern among sea ports, and these are mostly mentioned in details within Swedish actors. Providing statistics varies among companies, and in some sea ports these are provided from very long time period, where in others from just previous years or then only from last year (or even at all). It is common for companies to report that they have sustainable hinterland access, railway available.
Clinical applications of custom 3D printed implants in complex lower extremity reconstruction
Authors: Kadakia Rishin J. , Wixted Colleen M. , Allen Nicholas B. , Hanselman Andrew E. , Adams Samuel B. 
Published: October 2020

Abstract
Background
Three dimensional printing has greatly advanced over the past decade and has made an impact in several industries. Within the field of orthopaedic surgery, this technology has vastly improved education and advanced patient care by providing innovating tools to complex clinical problems. Anatomic models are frequently used for physician education and preoperative planning, and custom instrumentation can assist in complex surgical cases. Foot and ankle reconstruction is often complicated by multiplanar deformity and bone loss. 3D printing technology offers solutions to these complex cases with customized implants that conform to anatomy and patient specific instrumentation that enables precise deformity correction.

Case presentation
The authors present four cases of complex lower extremity reconstruction involving segmental bone loss and deformity – failed total ankle arthroplasty, talus avascular necrosis, ballistic trauma, and nonunion of a tibial osteotomy. Traditional operative management is challenging in these cases and there are high complication rates. Each case presents a unique clinical scenario for which 3D printing technology allows for innovative solutions.

Conclusions
3D printing is becoming more widespread within orthopaedic surgery. This technology provides surgeons with tools to better tackle some of the more challenging clinical cases especially within the field of foot and ankle surgery.
Bayesian bootstrap quantile regression for probabilistic photovoltaic power forecasting
Authors: Bozorg Mokhtar , Bracale Antonio , Caramia Pierluigi , Carpinelli Guido , Carpita Mauro , De Falco Pasquale 
Published: October 2020

AbstractPhotovoltaic (PV) systems are widely spread across MV and LV distribution systems and the penetration of PV generation is solidly growing. Because of the uncertain nature of the solar energy resource, PV power forecasting models are crucial in any energy management system for smart distribution networks. Although point forecasts can suit many scopes, probabilistic forecasts add further flexibility to an energy management system and are recommended to enable a wider range of decision making and optimization strategies. This paper proposes methodology towards probabilistic PV power forecasting based on a Bayesian bootstrap quantile regression model, in which a Bayesian bootstrap is applied to estimate the parameters of a quantile regression model. A novel procedure is presented to optimize the extraction of the predictive quantiles from the bootstrapped estimation of the related coefficients, raising the predictive ability of the final forecasts. Numerical experiments based on actual data quantify an enhancement of the performance of up to 2.2% when compared to relevant benchmarks.
Teen activism leads to local laws banning single-use plastics: a two-year experiential learning journey
Authors: Burke Eleanor , Collins Christopher Ciano , Bergeron Lucy , Law Kara Lavender 
Published: October 2020

AbstractThis paper recounts the two-year journey of an eight-member public Massachusetts high school environmental club that set out to decrease their local community’s consumption of single-use plastics. In the academic years 2016–2018, launched by a presentation by co-author Dr. Kara Lavender Law, the students wrestled with the global problem of plastic environmental debris within their local sphere of influence. They petitioned town government to regulate against local merchants’ dispensing thin-film plastic bags or selling single-use plastic water bottles < 1 L in size. The journey called upon them to participate in the democratic process, and through it to inform the citizenry, entertain opposing viewpoints, counter strident opposition with facts, enlist allies, and build broad consensus. After a two-year process, the project arrived at a successful result. They learned through experience that with tenacity, they could make democracy work for their ethical ideals.
Bariatric surgery and cardiovascular outcome
Authors: Ammar Waleed , Basset Hossam Abdel , AL Faramawy Amr , Hegazy Tarek , Sharaf Yasser 
Published: October 2020

Abstract
Background
Obesity is recognized as a classic risk factor for atherosclerosis and subsequent cardiovascular disease (CVD). Weight loss after bariatric surgery has been associated with reduced CV mortality and total mortality in obese patients. Our aim was to study the impact of bariatric surgery on CV risk profile, cardiac structure, and function postoperatively.

Results
This prospective longitudinal study included 100 morbidly obese patients at final analysis. All patients were subjected to full clinical, laboratory, and echocardiographic examination at baseline and 6 months after bariatric surgery. The mean age of study population was 37.2 ± 10.49 with BMI of 47 ± 6.82. Females represented 84%. Sleeve gastrectomy and Roux-en-Y gastric bypass were performed in 79% and 21%, respectively. Surgery-related mortality and morbidity were 0.94% and 4.7%, respectively. After 6 months, there were significant decreases in BMI, heart rate, SBP, DBP, and Framingham risk score (P < 0.0001). The prevalence of risk factors decreased as follows: hypertension 24% vs. 12%, P = 0.0005; DM 21% vs. 11%, P = 0.002; dyslipidemia 32% vs. 7%, P < 0.0001; and metabolic syndrome 54% vs. 26%, P < 0.0001. Highly significant (P < 0.0001) decrease in fasting PG and 2 h PP-PG, HbA1c, ASL, ALT, fasting total cholesterol, LDL, TG, and increase in HDL were observed after bariatric surgery. There were significant shortening in QTc interval (P = 0.009), decrease in LV dimensions and LV mass index (P < 0.0001), and increase in LV EF% (P = 0.0003). BMI at follow-up showed significant positive correlation with age, Framingham risk score, and preoperative BMI (r = 0.289, P = 0.0036; r = 0.37, P = 0.0054; and r = 0.31, P = 0.0081, respectively).

Conclusion
In addition to enabling patients to achieve a substantial weight loss, bariatric surgery provides a myriad of health benefits. Weight reduction was associated with a favorable improvement in cardiovascular risk profile, cardiac structure, and function.
Exploiting Rules to Enhance Machine Learning in Extracting Information From Multi-Institutional Prostate Pathology Reports
Authors: Santus Enrico , Schuster Tal , Tahmasebi Amir M. , Li Clara , Yala Adam , Lanahan Conor R. , Prinsen Peter , Thompson Scott F. , Coons Samuel , Mynderse Lance , Barzilay Regina , Hughes Kevin 
Published: October 2020

PURPOSE Literature on clinical note mining has highlighted the superiority of machine learning (ML) over hand-crafted rules. Nevertheless, most studies assume the availability of large training sets, which is rarely the case. For this reason, in the clinical setting, rules are still common. We suggest 2 methods to leverage the knowledge encoded in pre-existing rules to inform ML decisions and obtain high performance, even with scarce annotations. METHODS We collected 501 prostate pathology reports from 6 American hospitals. Reports were split into 2,711 core segments, annotated with 20 attributes describing the histology, grade, extension, and location of tumors. The data set was split by institutions to generate a cross-institutional evaluation setting. We assessed 4 systems, namely a rule-based approach, an ML model, and 2 hybrid systems integrating the previous methods: a Rule as Feature model and a Classifier Confidence model. Several ML algorithms were tested, including logistic regression (LR), support vector machine (SVM), and eXtreme gradient boosting (XGB). RESULTS When training on data from a single institution, LR lags behind the rules by 3.5% (F1 score: 92.2% v 95.7%). Hybrid models, instead, obtain competitive results, with Classifier Confidence outperforming the rules by +0.5% (96.2%). When a larger amount of data from multiple institutions is used, LR improves by +1.5% over the rules (97.2%), whereas hybrid systems obtain +2.2% for Rule as Feature (97.7%) and +2.6% for Classifier Confidence (98.3%). Replacing LR with SVM or XGB yielded similar performance gains. CONCLUSION We developed methods to use pre-existing handcrafted rules to inform ML algorithms. These hybrid systems obtain better performance than either rules or ML models alone, even when training data are limited.