bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Zhengsui Wan in the Treatment of Acute Lymphoblastic Leukemia Based on Network Pharmacology and Experimental Validation
Authors: Yang Xiangdong , Yang Fujun , Yuan Pengying , Xie Juan , Fang Lijun , Sun Weilong , Tao Xia , Li Dixuan , Fan Chenyang , Ji Ning 
Published: December 2024

Background:
Zhengsui Wan (ZSW) is a commonly used traditional Chinese medicine
formula for treating Acute Lymphatic Leukemia (ALL) in our institution, and it has shown potential
efficacy. However, its mechanism of action (MoA) remains unclear. In this study, we systematically
explored the ZSW in ALL (in vitro and in vivo) using network pharmacology and molecular docking
techniques.

Methods:
Mass spectrometry was conducted to analyze possible active components in ZSW.
BALB/c mice were treated by ZSW aqueous decoction, and mesenchymal stem cells (MSCs) were
extracted for proteomic analysis to evaluate differentially expressed proteins. Moreover, proteins
associated with acute lymphoblastic leukemia in SwissTargetPrediction and GeneCards databases
were screened, and they intersected with differentially expressed proteins to obtain potential targets
for ZSW. Protein interactions were constructed for the selected targets. Then, we performed GO and
KEGG enrichment analysis on its basis and screened the core target through K-core. We validated it
by molecular docking with the top three actives in the molecular network in degree value. Finally,
we detected the regulation of ICAM1 in MSCs by ZSW by qRT-PCR.

Results:
We detected 182 active ingredients in ZSW and identified 725 differential proteins in ZSWtreated
mice, of which 25 were potential targets. Furthermore, MMP2, ICAM1, PSEN1, SLC9A1,
and MMP14 were identified as core targets using the PPI network and K-core screening. Moreover,
ZSW significantly downregulated ICAM1 expression in MSCs. GO and KEGG enrichment analyses
showed that the results of ZSW were coordinated through immunomodulatory, inflammation-related,
and drug resistance-related genes, including the PI3K-Akt, cAMP, and Wnt signaling pathways.
Molecular docking and molecular dynamics simulations indicated moderate binding capacity between
the active compounds and the screened target.

Conclusion:
In this study, we successfully identified possible active ingredients and predicted potential
targets and pathways for ZSW for the treatment of ALL. We provide a new strategy for further
research on the molecular basis of ZSW biological effects in ALL. In addition, the potential active
ingredients could provide new leads for drug discovery in ALL investigations.
CT-Guided Foramen Ovale Injection of Mesenchymal Stem Cells: First Human Case Report of Trigeminal Neuralgia Relief
Authors: Candido Kenneth , Prodromos Chadwick , Nenchev Kristian 
Published: December 2024

Introduction/Objective:
Trigeminal Neuralgia (TN) is an extremely painful condition
without an established treatment other than symptom-suppressive medications or temporary relief
from corticosteroid injections. Mesenchymal Stem Cells (MSCs) have demonstrated the ability to
enhance healing and reduce inflammation and pain without side effects. Our objective was to evaluate
the safety and efficacy of CT-guided foramen ovale MSC injection in the treatment of TN.

Methods:
A 48-year-old woman presented with a 22-year history of severe TN. Previous treatments,
including microvascular decompression, acupuncture, chiropractic adjustment, and hypnotism
had failed. Medications decreased pain, but produced severe bothersome mental clouding. After
proper informed consent, the patient elected trigeminal nerve injection in the foramen ovale
with AlloRx (vitrobiopharma.com Golden Colorado) umbilical cord-derived Mesenchymal Stem
Cells (MSCs). An experienced pain specialist with previous experience using CT guidance with
sedation to inject the trigeminal nerve in the foramen ovale with corticosteroids performed the injection
using 20 million MSCs. The patient reported no adverse events or complications related to
the treatment.

Results:
At 1 month post-treatment, the patient reported dramatically reduced pain/tingling, and
no longer needed medication, which resulted in the resolution of her mental clouding. At 12
months post-treatment, some symptoms recurred, but the patient maintained substantial cognitive
improvements and required a reduced dose of medication.

Conclusion:
We have demonstrated, for the first time, CT-guided MSC injection into the foramen
ovale to result in significant improvement in trigeminal neuralgia without side effects.
“Take off my death again”: la fragmentación y el devenir de Lady Lazarus en Sylvia Plath y Jennifer Rahim
Authors: Cortés London Odette de Siena 
Published: December 2024

Pensar en la noción de continuidad mediante la fragmentación permite problematizar la forma en la que se crean los vínculos entre dos autoras provenientes de contextos diferentes dentro de la literatura inglesa. Este proceso visibiliza la imposibilidad de una conjunción lineal y directa, mientras que propone concebir enlaces de maneras menos directas, pero más enriquecedoras. Además, la cualidad fragmentaria de este pensamiento abre figuras que podrían considerarse unidades cerradas para introducir multiplicidades en la forma de discursos multiculturales que entran en conversación. Tal es el caso de Lady Lazarus, leída como un tema-personaje que permite un cruce cultural entre los poemas “Lady Lazarus” (1965) de Sylvia Plath y “Lady Lazarus in the Sun” (2008) de Jennifer Rahim. En dichos textos, dos versiones del mismo personaje adquieren opacidad a partir de la fragmentación que se construye en un devenir constante que introduce a la figura en contextos distantes. Así, este artículo busca explorar la forma en la que las dos poetas entablan negociaciones identitarias complejas entre su voz poética, Lady Lazarus y otras voces e historias a través del cuerpo fragmentado en el devenir. En este intercambio, la fragmentación se convierte en una doble vía que, paradójicamente, construye al tema-personaje desde la multiplicidad, mientras deconstruye las materialidades disonantes que iniciaron el ciclo de muerte y renacimiento característico de Lady Lazarus. De este modo, el artículo aborda el devenir de los fragmentos como un proceso complejo en la construcción de identidades múltiples y subversivas en la poesía escrita por mujeres.
Деформационный критерий для определения расстояния между нормальными трещинами в железобетонных балках при плоском изгибе
Authors: Пекин Д. А. 
Published: December 2024

Выполнен краткий обзор развития нового раздела механики деформируемого твердого тела — механика железобетона. Для стержневых железобетонных элементов обосновывается целесообразность выделения нового подраздела — механики стержневых железобетонных элементов с нормальными трещинами. Подробно рассмотрены классические предпосылки и допущения для определения расстояния между нормальными трещинами в состоянии чистого изгиба и обосновывается необходимость их полного пересмотра на основе предельной растяжимости бетона и выработкой деформационного критерия. Предложена программа экспериментальных исследований для определения предельной растяжимости бетона совместно с арматурой при осевом растяжении призматических образцов. Рассмотрен пример определения расстояния между нормальными трещинами для консольной балки при действии равномерно распределенной нагрузки.
Фауна и летнее население птиц Карагайского природного биологического заказника (Челябинская область)
Authors: Гашек В.А. , Захаров В.Д. , Красуцкий Б.В. , Яско Д.А. 
Published: December 2024

По итогам орнитологических исследований, проводившихся на территории Карагайского природного биологического заказника в период 2008–2022 гг., составлен список видов птиц. В него вошло 134 вида, 118 из которых гнездятся или гнездование их предполагается. Доминантами по численности в 2006 г. в лесных биотопах были зяблик и лесной конёк. В группу субдоминантов входили пухляк, пеночка-теньковка, большая синица и мухоловка-пеструшка. В 2018 г. наиболее многочисленными оказались зяблик и лесной конёк. Несколько уступали им большая синица, обыкновенная горихвостка, пеночка-теньковка и большой пестрый дятел. Среди экологических группировок в заказнике преобладали дендрофилы (63% от всех видов). Доля лимнофилов составила 17%, кампофилов и склерофилов – по 10%. Обнаружены на гнездовании (или оно предполагается) такие характерные для таежного комплекса виды, как рябчик, глухая кукушка, длиннохвостая и бородатая неясыти, юрок, клёст-еловик, обыкновенный снегирь.
Based on the results of ornithological studies, conducted in the Karagai Biosphere Reserve in 2008–2022, a list of bird species has been compiled. It consists of 134 (including 118 breeding or, probably, breeding) species. In 2006, chaffinch and tree pipit dominated in number in forest biotopes. The group of subdominants included willow tit, common chiffchaff, great tit and pied flycatcher. In 2018, most numerous chaffinch and tree pipit slightly outnumbered great tit, common redstart, common chiffchaff, and great spotted woodpecker. In ecological groups, dendrophiles prevailed (63% of all species). The share of limnophiles made up 17%, campophiles and sclerophiles – 10% each. Characteristic of the taiga complex breeding (or expected to nest), species, i.e. hazel grouse, deaf cuckoo, long-tailed and great grey owls, bramble finch, common crossbill, and common bullfinch were encountered.
FEATURES OF THE STUDY OF SAFE DISCIPLINES BY MEDICAL STUDENTS AT THE CURRENT STAGE
Authors: Masykevich A.Yu. , Masykevich Yu.G. , Tkachuk S.S. 
Published: December 2024

The article examines the specifics of the study of safety disciplines in the system of higher educational institutions of Ukraine at the current stage.

The purpose of the research – to determine the priorities of training students of medical specialties in the field of safety disciplines and to determine approaches to modernizing their content at the current stage.

The object of the study was the safety disciplines studied by students of medical specialties of universities of Ukraine. Research was based on systemic and activity approaches in education, methods of comparison, generalization and conclusions.

Results. The paper analyzes the state of study of safety disciplines («Life safety», «Occupational safety in the industry», «Hygiene and ecology», «Civil protection»). It is shown that in many cases these disciplines were, at best, included in the curricula as subjects of free choice, or even not included in the educational programs at all. The final awareness of the importance of these issues came only after the large- scale armed aggression of the Russian Federation against Ukraine. This issue has gained considerable relevance for the education of medical students, future front-line specialists in the provision of first aid to the civilian population and combatants. Special attention should be paid to the issues of civil protection, organizing the safe stay of the population in emergency situations, carrying out work to eliminate the consequences of emergency situations, providing the population and combatants with the first aid for fractures, bleeding, thermal burns, chemical and radiation injuries, development of dynamic stereotypes and algorithms of actions during military operations. An important basis for this should be the international experience gained as a result of improving the efficiency of academic mobility of students.

Conclusions. Modernization of the teaching of safety disciplines for students of medical specialties at universities has become an urgent need of the hour. The formation and development of security competencies in terms of providing emergency aid, preserving the safety and life of the civilian population and military personnel should constitute the main content of security disciplines and be included in all educational and professional (educational) programs of educational specialties of universities as mandatory regulatory disciplines at the current stage.
Utilization of Coconut Plantation Weeds as a Sustainable Feedstock for Biochar Production
Authors: Dissanayaka Nuwandhya S. , Sandakelum Tharaka , Nuwarapaksha Tharindu D. , Udumann Shashi S. , Nugara Ruwani N. , Atapattu Anjana J. 
Published: December 2024

Summary
Biochar, a carbon-rich and highly porous material, is created through the process of pyrolysis, a thermal decomposition of raw materials conducted in a controlled, low or no oxygen environment. Our research aimed to investigate the feasibility of utilizing coconut plantation weeds as a potential source for biochar production. The study encompassed two essential phases: a laboratory experiment conducted at the Agronomy Division of the Coconut Research Institute and a field experiment at the Rathmalagara Research Center, affiliated with the same institute. In the laboratory experiment, biochar was produced from six distinct types of coconut plantation weeds, including Megathyrsus maximus, Imperata cylindrica, Lantana camara, Chromoleana odorata, Stachytarpheta jamaicensis, and Urena lobata. The biochar was produced at a temperature of 500°C, with a residence time of 30 minutes. The resulting biochar samples underwent comprehensive analysis to evaluate various characteristics, such as conversion efficiency, pH, electrical conductivity (EC), moisture content, volatile matter content, ash content, and fixed carbon content. The biochar derived from Megathyrsus maximus demonstrated the highest conversion efficiency of 32.76% and displayed high-quality characteristics. In the field experiment, biochar was produced using a double-chamber pyrolyzer and employed three different stocking densities, with Megathyrsus maximus as the primary feedstock. The outcomes revealed that the biochar generated at a high stocking density of 72.10 kgm-3 yielded a remarkable conversion efficiency of 32% and exhibited high-quality biochar. Based on the experimental findings, Megathyrsus maximus demonstrates strong potential as an ideal feedstock for biochar production at the field level using a double-chamber pyrolyzer. These results emphasize the potential for sustainable biochar production from readily available, renewable resources, such as weed biomass from coconut plantations, further highlighting the environmental and agricultural benefits of this approach.
Preservation Properties of Citrus Essential Oils in Fruits Against Food Spoilage Microorganisms
Authors: Ajayi-Moses Oluwatayo Benjamin , Ogidi Clement Olusola , Akinyele Bamidele Juliet 
Published: December 2024

Summary
Pre- and post-harvest spoilage of fruits due to microbial contamination leads to significant economic losses. Therefore, this study was conducted to evaluate the antimicrobial and preservative potential of citrus essential oils (CEOs) extracted from the peels of lime (Citrus aurantifolia), lemon (Citrus limon), and grapefruit (Citrus paradisi). Microorganisms were isolated from apples, cucumbers, tomatoes and oranges using conventional microbiological methods. The in vivo antimicrobial activity of CEOs was assessed against microorganisms in apparently healthy oranges and apples. Bacillus cereus and Penicillium digitatum caused the largest lesions on fruits, with diameters ranging from 28 to 37 mm and 36 to 46 mm, respectively. Disease severity of 86.55% and 91.67 % was observed in the untreated oranges following inoculation with Bacillus cereus and Penicillium digitatum, respectively. The combination of CEOs, applied at a concentration of 100 mg/mL, effectively prevented disease occurrence in both apples and oranges. In contrast, the unpreserved apples and oranges had the highest fungal counts of 9.40 x 106 and 3.55 x 107 CFU/g, respectively. CEOs were found to extend the shelf life of fruits and preserve their quality without altering organoleptic properties. The bioactive compounds in CEOs can be extracted and utilized as preservative agents to mitigate microbial spoilage of fruits.
Insight into Invertebrate Community in Solonchak Soil Type Using EDNA Metabarcoding – A Pilot Study
Authors: Lazić Cvijeta , Stefanović Milomir , Tubić Nataša Kočiš , Kuzmanović Ana , Radnović Dragan , Tamindžija Dragana , Milić Stanko , Vasin Jovica , Ninkov Jordana , Djan Mihajla 
Published: December 2024

Summary
Solonchaks are soils characterized by high concentrations of soluble salts. These soils form unique ecosystems that provide habitats for organisms adapted to such extreme conditions. Invertebrates are one of the groups of organisms that inhabit these soils and play a significant role in ecosystem resilience contributing to soil health and fertility. However, the diversity of invertebrates inhabiting the solonchaks remains underexplored. The development of eDNA metabarcoding method has facilitated the detection of soil invertebrates, overcoming the limitations of conventional labor-intensive and time-consuming methods. eDNA metabarcoding made it possible to study/monitor changes in soil invertebrate diversity. This pilot study employed eDNA metabarcoding to detect soil invertebrates in solonchak soils at two agricultural fields in Vojvodina, Serbia. Furthermore, we compared two analytical methods of eDNA metabarcoding data – clustering and denoising sequences. eDNА metabarcoding method proved to be effective in detection of invertebrates. Using BOLD database, 0.21% OTUs and 0.11% ESVs were successfully assigned to expected Invertebrate phyla (Arthropoda, Annelida and Nematoda), with two specific species identified: Aporrectodea jassyensis and Sminthurinus elegans. Comparison of the two analytical approaches, denoising and clustering, revealed that these approaches identified the same taxonomic categories. However, given the limited sample size, further studies should compare these two approaches using a more extensive dataset to better estimate their usefulness.
The Development of China’s Exports – Is There a Decoupling from the EU and the US?
Authors: Brühl Volker 
Published: December 2024

Abstract
Some observers warn that a high level of economic dependence on China could negatively affect the economic resilience of western economies and therefore recommend reducing such dependence by gradually decoupling from China. On the other hand, industry leaders emphasise the economic importance of China and warn against any kind of trade conflicts. Against this background, this article briefly analyses the development of China’s export strategy. It finds that the export intensity of the Chinese economy is diminishing and that exports are becoming more diversified overall. In addition, the relative importance of the United States and the European Union as export markets has been reduced, indicating a gradual decoupling of China from western economies. Conversely, exports to China have become more important for both the EU and the US. Although the figures remain at a non-critical level, Europe’s export activities could be more diversified as well.
Analysis Investigations of Thermal Performance in Microchannel Heat Sink with Jet Impingement
Authors: Liu Ping , Hu Lianghong , He Muye , Sun Ruiqi 
Published: December 2024

Microchannel heat sink and jet impact are effective cooling technologies that rapidly remove heat dissipation in the electronic devices at high heat flux. To realize higher heat transfer efficiency, using deionized water as working coolant, the microchannel heat sinks with jet impingement (MHSJ) have been considered to investigate the heat transfer and flow performance on heat exchange surface. The different target distances [Formula: see text] of 0.5–1.25 mm and rib structures including circular, rectangular, and triangular column ribs in MHSJ are studied numerically at [Formula: see text] (800–2200). The simulation results are that decreasing the [Formula: see text] in microchannel can augment the formation of vortices that can promote flow disturbance and the generation of turbulence. The microchannel with target distance of 0.5 mm has the beat heat transfer performance, the heat transfer coefficient of which is improved by 18.62% at [Formula: see text], relative to target distance of 1.25 mm. And the performance evaluation criterion (PEC) of the microchannel at [Formula: see text] always becomes higher than that for the other microchannels. In addition, compared to the microchannel with no rib, the microchannels with column ribs that can improve convective heat transfer coefficient on the heat exchange surface as a result of enlarging the heat transfer area have the better heat transfer and flow characteristic. The convective heat transfer coefficient of the microchannel with rectangular column ribs is 5.65% higher than that with no ribs at [Formula: see text].
Modulation of sleep quality, cardiac autonomic activity, and cognition by yoga in medical students
Authors: Mishra Prateek , Singh Abhinav , Agarwal Prerna , Mathur Mohit Kumar , Bhandari Bharti 
Published: December 2024

Objectives
The disturbed sleep quality among medical students due to their hectic schedule may negatively impact the cognition, consequently affecting their academic performance. With the hypothesis that short duration of simple yogic exercises may improve sleep quality and heart rate variability (HRV), and thus may improve cognitive abilities, the study aims to evaluate the outcome of short duration yoga training on HRV, cognition, and sleep in medical students.

Material and Methods
The participants of the study were young and apparently healthy medical students. The study commenced after the Institutional Scientific Re- search and Ethics Committee approval. The informed consent was taken from all the participants in writing. All parameters (height, weight, age, body mass index [BMI], systolic blood pressure [SBP], diastolic blood pressure [DBP], heart rate [HR]) along with HRV, sleep quality (using Pittsburgh Sleep Quality Index [PSQI]), and cognitive ability (using Trail Making Tests Parts A & B [TMTs-A&B]) were assessed in the participants at baseline. Thereaf- ter, the students practiced yoga (asanas, pranayama, and meditation) under supervision of a yoga instructor and a faculty for the duration of one hour every day for six weeks. Measurements were repeated after six weeks. Depending on the normality of data and data distribution, the comparison was done using Wilcoxon Signed Rank Test or dependent samples t-test. The level of significance was kept as p < 0.05.

Results
Following six weeks of yoga sessions, a significant improvement in the high frequency power normalized unit (HFnu) and total power in comparison to baseline values was observed: 53.25± 10.14 versus 59.57 ± 9.61 and 3238 ± 1133 versus 3473 ± 1130, respectively. Significant difference at six weeks between baseline and post yoga values was observed in TMT-A (30.16 ± 5.04 vs 19.84 ± 2.76) and TMT-B (69.96 ± 12.99 vs 49.24 ± 10.99). Sleep quality also improved significantly after yoga sessions (baseline PSQI score of 10.68 ± 1.79 and post-PSQI score of 4.12 ± 1.67).

Conclusion
It was concluded that one hour of supervised yoga session every day for six weeks can improve HRV, sleep quality, and cognitive ability among medical students. Medical students should practice yoga regularly to improve cognitive function and sleep and to reduce cardiovascular morbidity.
Évite de te connaître toi-même !
Authors: Wotling Patrick 
Published: December 2024

En quel sens Nietzsche entend-il exactement la formule bien connue « comment on devient ce qu’on est », qu’il emprunte à Pindare et reprend sous des formes variées tout au long de son œuvre ? Ce, d’autant plus que son identification à la mise en évidence d’une identité cachée, profonde et authentique est parfaitement intenable. Au contraire, nous sommes toujours plusieurs, souligne Nietzsche. On établira donc que devenir ce que l’on est désigne une réorganisation pulsionnelle menée (ou que l’on échoue à mener) selon la logique de l’intensification de puissance.