bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis inCaenorhabditis elegans
Authors: Voss Laura , Foster Olivia K , Harper Logan , Morris Caitlin , Lavoy Sierra , Brandt James N , Peloza Kimberly , Handa Simran , Maxfield Amanda , Harp Marie , King Brian , Eichten Victoria , Rambo Fiona M , Hermann Greg J 
Published: December 2019

AbstractABC transporters couple ATP hydrolysis to the transport of substrates across cellular membranes. This protein superfamily has diverse activities resulting from differences in their cargo and subcellular localization. Our work investigates the role of the ABCG family member WHT-2 in the biogenesis of gut granules, a Caenorhabditis elegans lysosome-related organelle. In addition to being required for the accumulation of birefringent material within gut granules, WHT-2 is necessary for the localization of gut granule proteins when trafficking pathways to this organelle are partially disrupted. The role of WHT-2 in gut granule protein targeting is likely linked to its function in Rab GTPase localization. We show that WHT-2 promotes the gut granule association of the Rab32 family member GLO-1 and the endolysosomal RAB-7, identifying a novel function for an ABC transporter. WHT-2 localizes to gut granules where it could play a direct role in controlling Rab localization. Loss of CCZ-1 and GLO-3, which likely function as a guanine nucleotide exchange factor (GEF) for GLO-1, lead to similar disruption of GLO-1 localization. We show that CCZ-1, like GLO-3, is localized to gut granules. WHT-2 does not direct the gut granule association of the GLO-1 GEF and our results point to WHT-2 functioning differently than GLO-3 and CCZ-1. Point mutations in WHT-2 that inhibit its transport activity, but not its subcellular localization, lead to the loss of GLO-1 from gut granules, while other WHT-2 activities are not completely disrupted, suggesting that WHT-2 functions in organelle biogenesis through transport-dependent and transport-independent activities.
Notes sur l’origine du pouvoir politique selon Francisco de Vitoria
Authors: Valadares Jeferson Da Costa 
Published: December 2019

Ce texte fait d’une façon générale quelques brèves remarques sur la conception de Dieu comme l’origine du pouvoir politique chez Francisco de Vitoria (1486-1546) au XVIe siècle. Dans la Relectio de potestate civili, § 6 (Conférence sur le pouvoir politique) le dominicain espagnol analyse en effet les causes du pouvoir politique, notamment la cause efficiente du pouvoir politique et dit: Quae enim apud omnes naturalia sunt, a Deo auctore naturae, sine dubio (En effet, ce qui est naturel à tous les hommes vient sans aucun doute de Dieu, l’auteur de la nature). La contribution majeure de la philosophie de Vitoria consiste dans la formulation théologique et philosophico-juridique de Dieu comme cause efficiente du pouvoir politique. Mon objectif dans ce travail est d’analyser et de reconstruire les arguments dont Vitoria fait usage pour élaborer sa doctrine sur l’origine du pouvoir politique. Mon hypothèse est que cette idée s’enracine dans la pensée aristotélicienne et théologique. Ma stratégie pour construire ces brèves remarques s’organise de la façon suivante: I. Introduction; II. L’analyse de la nature du pouvoir politique; III. Thèmes; IV. La théorie du pouvoir politique: à la recherche de la cause efficiente; V. Conclusion.
Entre a clausura e o hospital: atuação das Irmãs de Jesus na Santíssima Eucaristia na Santa Casa de Cachoeiro de Itapemirim
Authors: Francelino Luciene Carla Corrêa 
Published: December 2019

O presente trabalho tem como objeto de análise a atuação das Irmãs de Jesus na Santíssima Eucaristia na Santa Casa de Misericórdia de Cachoeiro de Itapemirim – cidade localizada ao sul do estado do Espírito Santo - entre os anos de 1929 a 1950. Buscar-se- á discutir como o proceder das religiosas junto aos doentes e seus familiares, introduziu um modelo de cuidado fundamentado na caridade, acolhendo a todos que de alguma maneira dependiam da assistência do hospital. A pesquisa visa analisar como as mudanças causadas pela institucionalização da enfermagem chegaram ao município e de que maneira estas repercutiram no dia a dia da instituição. Pretende-se também compreender como as relações de poder no interior do hospital se alteraram na medida em que o conceito de cuidar presente na prática cotidiana das Irmãs vai sendo paulatinamente transformado pelo pressuposto do curar, praticado pela medicina. Palavras-chave: Religiosas; Clausura; Santa Casa.
Dohnányi und die Tradition Das Klavierquintett Nr. 2 es-Moll, op. 26 (1914)
Authors: Vondráček David 
Published: December 2019

Abstract
Dohnányi's Second Piano Quintet in E-flat minor was written in 1914 and is less well-known than his first one dating from 1895. The composer has been called a traditionalist, so it is worth examining how tradition appears in this work. The outer movements of the three-movement-form are both elegiac and weighty. The beginning bears the key signature of E-flat major instead of minor, but the keys are changing rapidly as the piece progresses. This is reminiscent of Franz Schubert or of Antonín Dvořák, for instance in his Piano Quartet (op. 87) inspired by Brahms. The third movement's opening is a homage to Beethoven's late String Quartet in A Minor (op. 132). While the latter works on a sub-thematic level, Dohnányi presents an elaborated theme in fugal technique, which in 1914 was a more conservative approach than Beethoven's in 1825. For Dohnányi, the symmetric structures are not a way out of traditional tonality (unlike for Bartók, who also frequently used symmetries), but rather are a way of extending it. The formal concept is no less interesting. The recapitulation of the first movement's material within the third is evocative of the double-function form used by Franz Liszt. While Liszt conflated the traditional multi-movement form into a new one-movement form, Dohnányi – so to speak – concealed the characteristics of the new one-movement form inside a traditional three-movement form. Thus, one could ask if the accusations against Dohnányi for being a traditionalist are justified. Perhaps instead we should reconsider how traditionalism and modernity are situated in our own set of aesthetic values.
Folklorism and Classical Tradition in László Lajtha's Late String Quartets
Authors: Ozsvárt Viktória 
Published: December 2019

Abstract
The gains from the folk music collection movement initiated by Béla Bartók and Zoltán Kodály in the first decade of the twentieth century set a path for Hungarian music theory that continued to influence the approach to composition in later decades. Placing folklore material in composed, classical works is complicated by tonal and formal problems and by political overtones. For quotations or thematic material from folk music may introduce complex implications and associations. So the way a composer imbues folk music calls for more than mere technical skill – it embodies an artistic statement. This article analyzes two works by the Hungarian composer and ethnomusicologist László Lajtha (1892–1963): his string quartets nos. 7 and 10 completed in the early 1950s. Through these two quartets I attempt to fathom the aesthetic, ideological and personal motives behind Lajtha's use of folk material in classical composition. Analysis of the composing process involved and the reception the two works received reveal the manifold scope that folk music brings as a source of inspiration.
Osmanlı’dan Cumhuriyet’e Yakup Kadri’nin Kadınlığa Bakışını Değerlendirmek
Authors: KUZGUN Meral 
Published: December 2019

Türk tarihinde Türk kadının toplum hayatı içindeki yeri ve önemi dönemin sosyal, ekonomik, kültürel ve dini değerleri çerçevesinde büyük bir değişim göstermiştir. Kadının konumu ve hakları sorunu, II. Meşrutiyet’ten sonra feminizmin etkisi altına girmiştir. Bu dönemde birçok Türk aydını, Türk toplumunun gelişmesini; kadının ilerlemesine engel olan sebeplerin ortadan kaldırılmasına bağlamıştır. Böyle bir atmosfer içinde feminist çizgiden tamamen ya da kısmen ayrılan Yakup Kadri
Karaosmanoğlu’nun Kadınlık ve Kadınlarımız isimli eserinin muhalif bir izlenim oluşturduğu söylenebilir. Yakup Kadri Karaosmanoğlu, kaleme aldığı Kadınlık ve Kadınlarımız adlı eserini, Osmanlı Devleti’nin içinde bulunduğu Birinci Dünya Harbi ve sonrasındaki Milli Mücadele döneminin getirdiği ağır ve yorucu sürecin aşılmasından sonra 1923 yılında yayınlamıştır. Bu çalışmanın amacı; Yakup Kadri’nin gün ışığına pek çıkmamış bu eserindeki Müslüman Türk kadın tipini, II. Meşrutiyet sonrasında kuvvet bulmaya başlayan feminist yaklaşımlarla mukayese ederek bilim dünyasına tanıtmak ve kadın meselesine bakışındaki temel noktaları ortaya koyabilmektir.
Napolyon’un Şark Politikasını İhyâ Etmek: Horace Compte Sebastiani’ın İstanbul-Mısır Seyahatleri (1801–1802) ve Raporları
Authors: YENİDÜNYA Süheyla 
Published: December 2019

Akdeniz ve hinterlandı, dünya deniz ticaretinin önemli merkezlerinden biridir ve bu özelliği nedeniyle de tarihin her döneminde devletlerarasında büyük ticarî/ siyasî rekabete sahne olmuştur. Söz konusu coğrafyanın tarih boyunca değişmeyen bu gerçeğine, Avrupa’da yaşanan Sanayi Devrimi sonrasında yeni siyasî aktörler dâhil olmuştur. Akdeniz hinterlandının stratejik öneme sahip parçalarından biri olan Mısır ise hızla sanayileşen devletler tarafından geniş bir hammadde kaynağı ve pazar olarak görülen Doğu’nun kapısı konumundaydı. Doğal olarak bu yaklaşım, Mısır’ı uluslararası rekabetin başlıca unsurlarından biri kılmıştır. Devrin önemli siyasî aktörlerinden biri olan İhtilal Fransa’sı, bu yarışta öne geçmek amacıyla 1798 yılında Mısır’ı işgal etmişti. Ancak, en azından hukuken Mısır’ın hâkimi konumundaki
Osmanlı Devleti’nin bu hamleye İngiltere ve Rusya ile ittifak kurarak karşılık vermesi sonucunda Fransa, Mısır’ı ele geçirmek şöyle dursun bölgedeki üstünlüğü İngiltere ve Rusya’ya kaptırmıştı. Mısır’daki güç oyunlarında avantajlı konumunu kaybeden Napolyon, “Grande Pensee” olarak bilinen Doğu’ya hâkim olma düşüncesinden asla vazgeçmeyerek 1798 de savaş yoluyla kazanamadığı Mısır’ı barış ve diplomasi yoluyla ele geçirmeye çalışmıştır. Söz konusu politikanın öncelikli hedefi, Mısır’ın işgali esnasında Fransa’ya karşı oluşan Osmanlı-Rus-İngiliz bloğunu parçalamak ve bu parçalanmışlık içerisinde Mısır’da dolayısıyla Akdeniz ve hinterlandında Fransa’ya yeniden yer bulmaktı. Bu çalışmada, İhtilal Fransa’sının yıldızı parlayan lideri Napolyon Bonapart’ın Doğu siyasetinin hayata geçirilmesinde etkin ve belirleyici bir rol oynayan Horace Comte Sebastiani’ın 1801 İstanbul-1802 Kuzey Afrika-Mısır seyahatleri ve raporları değerlendirilecektir.
Importance of cytokines in the pathogenesis of preeclampsia in pregnant women with iron deficiency anemia
Authors: Dzhabbarova Yulduz K. , Ismoilova Shoira T. , Musakhodzhayeva Dilorom A. 
Published: December 2019

Hypothesis/aims of study. The frequency of hypertension in iron deficiency anemia (IDA) reaches 3245%. The pathogenesis of pregnancy complicated with anemia and preeclampsia, including immunological aspects, has been little studied. The aim of this study was to clarify the role of general and local cytokine status violations in pregnant women with anemia in the genesis of preeclampsia and to justify the need for inclusion of immunosuppressive agents for the prevention and treatment of preeclampsia.
Study design, materials and methods. The cytokine status (IL-1, IL-6, IL-8, TNF) and the level of lactoferrin in peripheral blood serum and in extracts of the placental decidual tissue were examined by ELISA in 96 pregnant women with IDA and preeclampsia in the third trimester of gestation. Pregnant women were divided into four groups: 24 with mild anemia, 18 with moderate anemia, 26 with preeclampsia and mild anemia, and 28 with preeclampsia and moderate anemia.
Results. It has been shown that preeclampsia, along with IDA, is accompanied by a significant increase in the level of pro-inflammatory cytokines and the acute phase protein lactoferrin at the systemic and, to a greater extent, local level, that is in the decidual membrane of the placenta, in the development of preeclampsia against the background of moderate anemia. The data obtained confirm the involvement of the immune system in the pathogenesis of preeclampsia, one of the triggers of which is the immune imbalance in IDA. A pathogenetic rationale for the use of immunosuppressive therapy for combined pathology is given.
Conclusion. The use of placental hormone progesterone as an immunosuppressive drug in terms of substantiating new immunotherapy strategies for the prevention and treatment of preeclampsia is a topical trend in obstetric practice.
Real-Time High-Rate GNSS Displacements: Performance Demonstration during the 2019 Ridgecrest, California, Earthquakes
Authors: Melgar Diego , Melbourne Timothy I. , Crowell Brendan W. , Geng Jianghui , Szeliga Walter , Scrivner Craig , Santillan Marcelo , Goldberg Dara E. 
Published: December 2019

AbstractTraditional real-time (RT) seismology has relied on inertial sensors to characterize ground motions and earthquake sources, particularly for hazards applications such as warning systems. In the past decade, a revolution in high-rate, RT Global Navigation Satellite Systems (GNSS) displacement has provided a new source of data to augment traditional measurement devices. The Ridgecrest, California, earthquake sequence in 2019 provided one of the most complete recordings of RT-GNSS displacements to date, helping aid in an initial source characterization over the first few days. In this article, we analyze and make available the archived RT displacement streams and compare their performance to postprocessed results, which we also provide. We find good agreement for all stations showing a noticeable signal. This demonstrates that simple modeling in RT, such as peak ground displacement scaling, would be practically identical to postprocessed results. Similarly, we find good agreement across the full spectral range, from the coseismic offsets (∼0  Hz) to the Nyquist frequency. We also find low latency between the measurement acquisition at the field site and the position calculation at the data center. In aggregate, the performance during the Ridgecrest earthquakes is strong evidence of the viability and usefulness of RT-GNSS as a monitoring tool.
O nome social como uma categoria antroponímica para a garantia do princípio da dignidade da pessoa humana / Social Name as an Anthroponymic Category for Guaranteeing the Principle of Human Dignity
Authors: Amaral Eduardo Tadeu Roque , Oliveira Isabela Fernanda do Nascimento 
Published: December 2019

Resumo: Com base em pressupostos da Sócio-onomástica, este trabalho tem como objetivo analisar o nome social como uma categoria da antroponímia brasileira. Para isso, observa-se a inserção do termo nome social no ordenamento jurídico brasileiro e, em seguida, analisam-se as estratégias de referência a pessoas trans em notícias sobre a violência a esse grupo publicadas na internet entre 2008 e 2017. A análise revela que o termo nome social começa a ser usado nas normas brasileiras de âmbito nacional nos últimos anos da primeira década do século XXI, mas sua frequência em textos de notícias tem sido baixa. Em todo caso, verifica-se que o reconhecimento do nome social constitui, nos dois conjuntos de textos, uma forma de garantia do princípio da dignidade da pessoa humana.Palavras-chave: Sócio-onomástica; antropônimo; nome social.Abstract: Based on theoretical assumptions of the Socio-onomastics, this work aims to analyze the social name as a category of Brazilian anthroponymy. To reach this purpose, the inclusion of the term nome social (social name) in the Brazilian legal system is observed. We also analyse the strategies of reference to trans people in the news about violence against this group published on the Internet between 2008 and 2017. The analysis leaves room for observing that the term nome social was first used in the Brazilian national norms in the last years of the first decade of the 21st century, but its frequency in the news has been low. Notwithstanding, the recognition of the social name constitutes, in both sets of texts, a way to guarantee the principle of human dignity.Keywords: Socio-onomastics; anthroponym; social name.
Genogram Kullanımına Yönelik Çalışmaların İncelenmesi
Authors: KARAKUŞ Sena , ERKAN Zülal 
Published: December 2019

Bowen Aile Sistemi Kuramı’nda yaygın olarak kullanılan bir teknik olan genogram aile bilgilerinin grafiksel olarak gösterildiği klinik bir araçtır. Genogramlarda üç kuşak olarak aile kökenlerine, aile içi ilişkilere, sağlık sorunlarına, aile içindeki önemli olaylara (kayıp vb.) ilişkin bilgiler yer almaktadır. Bu araştırmanın amacı, genogram kullanımını içeren alanyazın çalışmalarını değerlendirmektir. Bu amaç doğrultusunda 2000-2019 yılları arasında genogram tekniği ile ilgili ERIC ve Web of Science veri tabanında yer alan uluslararası, ARASTIRMAX, ULAKBIM, DergiPark veri tabanlarında yer alan ulusal makaleler ve Yükseköğretim Kurulu Ulusal Tez Arşivi’nde yer alan tez incelenmiştir. Araştırmalar yöntem, örneklem, uygulandığı alan, kullanılan genogram türü ve yayın türü alt boyutları açısından değerlendirilerek gelecek çalışmalara bakış açısı kazandırılmaya çalışılmıştır.
The Diagnostic Accuracy of Сoronary Сomputed Tomography Angiography in the Diagnosis of Stable Coronary Artery Disease in Patients Aged 70 Years and Older
Authors: Kozlov S. G. , Chernova O. V. , Veselova T. N. , Ternovoy S. K. 
Published: December 2019

Aim: The purpose of this study was to evaluate the diagnostic accuracy of сoronary сomputed tomography angiography (CCTA) in the diagnosis of stable coronary artery disease (CAD) in patients aged ≥70 years. Materials and methods: The study included 390 patients aged ≥70 years with symptoms suggested stable CAD which underwent elective coronary artery angiography (CAG). Initially the prevalence of angiographically significant CAD was estimated according to the gender and chest pain character, and identifications of patients in whom CCTA was appropriate. After that diagnostic accuracy and сost-efficiency of CCTA in the diagnosis of stable CAD in 82 patients with atypical angina and non-anginal chest pain were evaluated. Results: The prevalence of obstructive CAD in patients with typical angina was very high and they were excluded from the final analysis. Among 82 patients with atypical angina and non-anginal pain which underwent CCTA 48 (59%) patients had obstructive CAD. CСTA data matched with results of CAG in all cases. Among 34 patients that had non-obstructive CAD the results of CCTA and CAG matched in 88% cases. CCTA has sensitivity, specificity, positive predictive value, negative predictive value of 100%, 88%, 92% and 100% respectively. The likelihood ratio for positive result was 8.3, likelihood ratio for negative result was 0.3. Positive result increased post-test probability of obstructive CAD from 42% to 86%, negative result reduced post-test probability of obstructive CAD to 0%. Conclusion: negative CCTA result in patients aged 70 years and older with atypical angina and non-anginal pain allows to exclude the presence of obstructive CAD. The likelihood ratio for positive result indicates a moderately difference between the pre-test and post-test probability of the presence of obstructive CAD. In patients aged ≥70 years with atypical angina or non-anginal chest pain which have inconclusive results of functional testing or unable undergo functional testing CCTA allows to increase diagnostic yield of CAG and reduce the frequency of minor complications and diagnostic evaluation costs.
The study of the possibility of using the predatory tick Amblyseius longispinosus to control spider mites in agrocenoses of Dagestan
Authors: Misrieva B. U. 
Published: December 2019

Relevance. The introduction of plant protection systems with minimal use of pesticides is one of the main conditions for improving the environment. Phytosanitary construction of agrocenoses is the basis of plant-free plant protection. The creation of agrocenoses with a balanced predatorprey system by stimulating self-regulation mechanisms that create favorable conditions for the accumulation of natural predatory entomophages is a very promising direction in the biologization of plant protection.Methods. For 10 years, the author conducted faunistic studies, identified predatory entomoacarifagi, and showed their regulatory role in the fight against spider mites on grapes. It is established that in addition to the destruction of the spider mite on grapes, predatory mites are able to suppress the number of thrips and whiteflies. The article describes the relationship in the predatorprey system for the predatory tick Amblyseius longispinosus, which is a specialized monophage.Results. Based on many years of research, the regulatory role of the predatory tick Amblyseius longispinosus has been shown. Its high efficiency against spider mites has been proved. 12-15 days with a predator:prey ratio of 1:2, 1:3 and 1:4. Based on sketches and biometric measurements, the morphological description of Amblyseius longispinosus is supplemented. Based on the obtained research results, methods have been developed to create reproducible reserves of the number of predatory ticks in agrocenoses of Dagestan.
Preliminary study of traditional selection potato varieties resistance for potatoes ladybug Henosepilachna vigintioctopunctata Motch. (Fabricius, 1775) in the Primorsky territory
Authors: Matsishina N. V. , Shaybekova A. S. , Boginskaya N. G. , Sobko O. A. , Volkov D. I. , Kim I. V. 
Published: December 2019

Relevance. Potato ladybug is a polyphagous pest. Its distributed throughout the Far East, in India, Korea, Japan and the countries of South America. Most affected by it are potatoes, tomatoes, eggplant, zucchini, peppers, cucumbers, pumpkin, melon, beans. Leaving the veins intact pest eats the soft tissue of the leaf. Such leaves die quickly. Potato ladybug is a carrier of some diseases of potato and it also causes damage to plants. But insecticides pollute products and sustainable insect populations. The use of varieties with high resistance to pest damage eliminates the need for mass application of insecticides.Methods. The data on a preliminary assessment of potato varieties of domestic and foreign selection for resistance to a twenty-eight-point potato ladybug Henosepilachna vigintiomaculata Motch. (Fabricius, 1775) in the Primorye Territory. This work aim work was a preliminary assessment of the traditional potato breeding resistance factors to pest damage. The experiment out using generally accepted methods for the study and evaluation of potato varieties for pests with minor modifications was carried.Results. As a study result it was found that Belmonda, Labella, Red Lady, Queen Anna, Lilly, Sante varieties were the least suitable for passing the stages of ontogenesis and nutritional nutrition of the pest. The most tolerant to the pest – varieties Smak, Casachok, Yantar. The maximum mortality of potato ladybug larvae was observed in varieties Belmonda, Dachny, Augustin, Yubilyar, Labella, Sante, Koroleva Anna, Laperla in laboratory experiment. Minimum on varieties Smak, Casachok, Yantar, Red Lady. The data indicate the manifestation of an antibiotic barrier in potatoes, which must be confirmed by a field experiment.