bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effusion attenuates the effect of synovitis on radiographic progression in patients with hand osteoarthritis: a longitudinal magnetic resonance imaging study
Authors: Damman W. , Liu R. , Reijnierse M. , Rosendaal F. R. , Bloem J. L. , Kloppenburg M. 
Published: August 2020

AbstractAn exploratory study to determine the role of effusion, i.e., fluid in the joint, in pain, and radiographic progression in patients with hand osteoarthritis. Distal and proximal interphalangeal joints (87 patients, 82% women, mean age 59 years) were assessed for pain. T2-weighted and Gd-chelate contrast-enhanced T1-weighted magnetic resonance images were scored for enhanced synovial thickening (EST, i.e., synovitis), effusion (EST and T2-high signal intensity [hsi]) and bone marrow lesions (BMLs). Effusion was defined as follows: (1) T2-hsi > 0 and EST = 0; or 2) T2-hsi = EST but in different joint locations. Baseline and 2-year follow-up radiographs were scored following Kellgren-Lawrence, increase ≥ 1 defined progression. Associations between the presence of effusion and pain and radiographic progression, taking into account EST and BML presence, were explored on the joint level. Effusion was present in 17% (120/691) of joints, with (63/120) and without (57/120) EST. Effusion on itself was not associated with pain or progression. The association with pain and progression, taking in account other known risk factors, was stronger in the absence of effusion (OR [95% CI] 1.7 [1.0–2.9] and 3.2 [1.7–5.8]) than in its presence (1.6 [0.8–3.0] and 1.3 [0.5–3.1]). Effusion can be assessed on MR images and seems not to be associated with pain or radiographic progression but attenuates the association between synovitis and progression.

Key Points• Effusion is present apart from synovitis in interphalangeal joints in patients with hand OA.• Effusion in finger joints can be assessed as a separate feature on MR images.• Effusion seems to be of importance for its attenuating effect on the association between synovitis and radiographic progression.
Understanding the effects of dietary components on the gut microbiome and human health
Authors: Rackerby Bryna , Kim Hyun Jung , Dallas David C. , Park Si Hong 
Published: August 2020

AbstractThe gut microbiome is the complex microbial ecosystem found in the gastrointestinal tract of humans and animals. It plays a vital role in host development, physiology and metabolism, and has been implicated as a factor in brain function, behavior, mental health, and many disease states. While many factors, including host genetics and environmental factors, contribute to the composition of the gut microbiome, diet plays a large role. Microorganisms differ in their nutrient requirements, and alterations in host dietary composition can have strong impacts on the microbial inhabitants of the gastrointestinal tract. The health implications of these dietary and microbial changes are relevant as various global populations consume diets comprised of different macronutrient ratios, and many diets promote alterations to recommended macronutrient ratios to promote health. This review will outline the ways in which specific macro- and micronutrients impact the gut microbiome and host health.
Enhancing production and flow of freshwater ecosystem services in a managed Himalayan river system under uncertain future climate
Authors: Momblanch Andrea , Beevers Lindsay , Srinivasalu Pradeep , Kulkarni Anil , Holman Ian P. 
Published: August 2020

AbstractFuture climate change will likely impact the multiple freshwater ecosystem services (fES) provided by catchments through their landscapes and river systems. However, there is high spatio-temporal uncertainty on those impacts linked to climate change uncertainty and the natural and anthropogenic interdependencies of water management systems. This study identifies current and future spatial patterns of fES production in a highly managed water resource system in northern India to inform the design and assessment of plausible adaptation measures to enhance fES production in the catchment under uncertain climate change. A water resource systems modelling approach is used to evaluate fES across the full range of plausible future scenarios, to identify the (worst-case) climate change scenarios triggering the greatest impacts and assess the capacity of adaptation to enhance fES. Results indicate that the current and future states of the fES depend on the spatial patterns of climate change and the impacts of infrastructure management on river flows. Natural zones deliver more regulating and cultural services than anthropized areas, although they are more climate-sensitive. The implementation of a plausible adaptation strategy only manages to slightly enhance fES in the system with respect to no adaptation. These results demonstrate that water resource systems models are powerful tools to capture complex system dependencies and inform the design of robust catchment management measures. They also highlight that mitigation and more ambitious adaptation strategies are needed to offset climate change impacts in highly climate-sensitive catchments.
The effects of incidental findings from whole-body MRI on the frequency of biopsies and detected malignancies or benign conditions in a general population cohort study
Authors: Richter Adrian , Sierocinski Elizabeth , Singer Stephan , Bülow Robin , Hackmann Carolin , Chenot Jean-François , Schmidt Carsten Oliver 
Published: August 2020

AbstractMagnetic resonance imaging (MRI) yields numerous tumor-related incidental findings (IFs) which may trigger diagnostics such as biopsies. To clarify these effects, we studied how whole-body MRI IF disclosure in a population-based cohort affected biopsy frequency and the detection of malignancies. Laboratory disclosures were also assessed. Data from 6753 participants in the Study of Health in Pomerania (SHIP) examined between 2008 and 2012 were utilized. All underwent laboratory examinations and 3371 (49.9%) a whole-body MRI. Electronic biopsy reports from 2002 to 2017 were linked to participants and assigned to outcome categories. Biopsy frequency 2 years pre- and post-SHIP was investigated using generalized estimating equations with a negative-binomial distribution. Overall 8208 IFs (laboratory findings outside reference limits: 6839; MRI: 1369) were disclosed to 4707 participants; 2271 biopsy reports belonged to 1200 participants (17.8%). Of these, 938 biopsies occurred pre-SHIP; 1333 post-SHIP (event rate/100 observation years = 6.9 [95% CI 6.5; 7.4]; 9.9 [9.3; 10.4]). Age, cancer history, recent hospitalization, female sex, and IF disclosure were associated with higher biopsy rates. Nonmalignant biopsy results increased more in participants with disclosures (post-/pre-SHIP rate ratio 1.39 [95% CI 1.22; 1.58]) than without (1.09 [95% CI 0.85; 1.38]). Malignant biopsy results were more frequent post-SHIP (rate ratio 1.74 [95% CI 1.27; 2.42]). Biopsies increased after participation in a population-based cohort study with MRI and laboratory IF disclosure. Most biopsies resulted in no findings and few malignancies were diagnosed, indicating potential overtesting and overdiagnosis. A more restrictive policy regarding IF disclosure from research findings is required.
Trajectories of Early Adolescent Loneliness: Implications for Physical Health and Sleep
Authors: Eccles Alice M. , Qualter Pamela , Panayiotou Margarita , Hurley Ruth , Boivin Michel , Tremblay Richard E. 
Published: August 2020

AbstractThe current study examines the relationship between prolonged loneliness, physical health, and sleep among young adolescents (10–13 years;N = 1214; 53% girls). Loneliness was measured at 10, 12 and 13 years of age along with parent-reported health and sleep outcomes. Using growth mixture modelling, 6 distinct trajectories were identified: ‘low increasing to high loneliness’ (n = 23, 2%), ‘high reducing loneliness’ (n = 28, 3%), ‘medium stable loneliness’ (n = 60, 5%), ‘medium reducing loneliness’ (n = 185, 15%), ‘low increasing to medium loneliness’ (n = 165, 14%), and ‘low stable loneliness’ (n = 743, 61%). Further analyses found non-significant differences between the loneliness trajectories and parent-report health and sleep outcomes including visits to health professionals, perceived general health, and sleep quality. The current study offers an important contribution to the literature on loneliness and health. Results show that the relationship may not be evident in early adolescence when parent reports of children’s health are used. The current study highlights the importance of informant choice when reporting health. The implications of the findings for future empirical work are discussed.
Supporting Expectant and Parenting Teens: New Evidence to Inform Future Programming and Research
Authors: Harding Jessica F. , Zief Susan , Farb Amy , Margolis Amy 
Published: August 2020

AbstractUntil recently, federal programs had not explicitly focused on improving the outcomes of highly vulnerable teen parents. Established in 2010, the Pregnancy Assistance Fund (PAF) aims to improve the health, social, educational, and economic outcomes for expectant and parenting teens and young adults, their children, and their families, through providing grants to states and tribes. This article introduces the Maternal and Child Health Journal supplement “Supporting Expectant and Parenting Teens: The Pregnancy Assistance Fund,” which draws together the perspectives of researchers and practitioners to provide insights into serving expectant and parenting teens through the PAF program. The articles in the supplement include examples of programs that use different intervention strategies to support teen parents, with programs based in high school, college, and community settings in both urban and rural locations. Some of the articles provide rigorous evidence of what works to support teen parents. In addition, the articles demonstrate key lessons learned from implementation, including allowing some flexibility in implementation while clearly outlining core programmatic components, using partnerships to meet the multifaceted needs of young parents, hiring the right staff and providing extensive training, using strategies for engaging and recruiting teen parents, and planning for sustainability early. The studies use a range of qualitative and quantitative methods to evaluate programs to support teen parents, and three articles describe how to implement innovative and cost effective methods to evaluate these kinds of programs. By summarizing findings across the supplement, we increase understanding of what is known about serving expectant and parenting teens and point to next steps for future research.
Glioma consensus contouring recommendations from a MR-Linac International Consortium Research Group and evaluation of a CT-MRI and MRI-only workflow
Authors: Tseng Chia-Lin , Stewart James , Whitfield Gillian , Verhoeff Joost J. C. , Bovi Joseph , Soliman Hany , Chung Caroline , Myrehaug Sten , Campbell Mikki , Atenafu Eshetu G. , Heyn Chinthaka , Das Sunit , Perry James , Ruschin Mark , Sahgal Arjun 
Published: August 2020

Abstract
Introduction
This study proposes contouring recommendations for radiation treatment planning target volumes and organs-at-risk (OARs) for both low grade and high grade gliomas.

Methods
Ten cases consisting of 5 glioblastomas and 5 grade II or III gliomas, including their respective gross tumor volume (GTV), clinical target volume (CTV), and OARs were each contoured by 6 experienced neuro-radiation oncologists from 5 international institutions. Each case was first contoured using only MRI sequences (MRI-only), and then re-contoured with the addition of a fused planning CT (CT-MRI). The level of agreement among all contours was assessed using simultaneous truth and performance level estimation (STAPLE) with the kappa statistic and Dice similarity coefficient.

Results
A high level of agreement was observed between the GTV and CTV contours in the MRI-only workflow with a mean kappa of 0.88 and 0.89, respectively, with no statistically significant differences compared to the CT-MRI workflow (p = 0.88 and p = 0.82 for GTV and CTV, respectively). Agreement in cochlea contours improved from a mean kappa of 0.39 to 0.41, to 0.69 to 0.71 with the addition of CT information (p < 0.0001 for both cochleae). Substantial to near perfect level of agreement was observed in all other contoured OARs with a mean kappa range of 0.60 to 0.90 in both MRI-only and CT-MRI workflows.

Conclusions
Consensus contouring recommendations for low grade and high grade gliomas were established using the results from the consensus STAPLE contours, which will serve as a basis for further study and clinical trials by the MR-Linac Consortium.
Wind and seed: a conceptual model of shape-formation in the cushion plant Azorella Selago
Authors: Combrinck Madeleine L. , Harms Thomas M. , McGeoch Melodie A. , Schoombie Janine , le Roux Peter Christiaan 
Published: August 2020

Abstract
Aims
The sub-Antarctic cushion plant, Azorella selago, is usually hemispherical when small but frequently crescent-shaped when larger. Spatial variation in wind speed and in air-borne seed and sediment deposition is examined to determine if wind scouring and deposition patterns could contribute to the development of non-hemispherical shapes in cushion plants.

Methods
Computational fluid dynamic analyses were conducted for hemispherical and crescent-shaped cushion plants parameterizing models with data from A. selago habitats on Marion Island. Numerical data were contextualized with field observations to arrive at a conceptual model for shape development.

Results
Airflow modelling showed that both wind scouring and seed deposition of the commonly co-occurring grass Agrostis magellanica are greater on the windward side of the plant. By contrast, heavier sediment particles are predominantly deposited on the leeward side of plants, leading to burial of lee-side A. selago stems. This sediment accumulation may initiate the development of the crescent-shape in hemispherical plants by increasing stem mortality on the plant’s leeward edge. Once developed, the crescent-shape is probably self-reinforcing because it generates greater air recirculation (and lower air velocities) which enhances further deposition and establishment of A. magellanica grasses in the lee of the crescent. The conceptual model consists therefore of three stages namely, (1) negligible air recirculation, (2) sediment deposition and grass establishment, and (3) differential cushion growth.

Conclusion
This conceptual model of plant shape development may explain the occurrence and orientation of crescent-shaped cushion plants and highlights how predicted changes in wind patterns may affect vegetation patterns.
Google Search Queries, Foreclosures, and House Prices
Authors: Damianov Damian S. , Wang Xiangdong , Yan Cheng 
Published: August 2020

AbstractWe study whether Google search behavior for “mortgage assistance” and “foreclosure help” aggregated in the mortgage default risk indicator (MDRI) of Chauvet et al. (2016) helps predict future house prices and foreclosures in local residential markets. Using a long-run equilibrium model, we disaggregate house prices into their fundamental and bubble components, and we find that MDRI dampens both components of house prices. This negative relationship is robust to various model specifications and time horizons. A higher intensity of search online, however, is associated with lower future foreclosure rates. We also find that foreclosure rates increase after a decline in the fundamental component of home values, but are not sensitive to their transitory (bubble) component. Foreclosure rates are higher in metropolitan areas located in non-recourse states. We interpret these findings as evidence for strategic household behavior. Our paper sheds new light on the predictive power of household sentiment derived from Google searches on prices and foreclosure rates in local housing markets.
Updated approach for the management of osteoporosis in Turkey: a consensus report
Authors: Kirazlı Yeşim , Atamaz Çalış Funda , El Özlem , Gökçe Kutsal Yeşim , Peker Özlen , Sindel Dilsad , Tuzun Şansın , Gogas Yavuz Dilek , Durmaz Berrin , Akarirmak Ülkü , Bodur Hatice , Hamuryudan Vedat , Inceboz Umit , Öncel Sema 
Published: August 2020

Abstract

Summary

As a result of the current demographics, increased projections of osteoporosis (OP) and prevalence of the disease in Turkey, a panel of multidisciplinary experts developed a thorough review to assist clinicians in identifying OP and associated fracture risk patients, diagnosing the disease with the appropriate available diagnostic methods, classifying the disease, and initiating appropriate treatment. The panel expects to increase the awareness of this prevalent disease, decrease consequences of OP with corresponding cost savings and, ultimately, decrease the overall burden of OP and related fractures in Turkey.

Background
OP is not officially accepted as a chronic disease in Turkey despite the high prevalence and predicted increase in the following years. However, there are areas where the country is performing well, such as having a country-specific fracture risk assessment model, DXA access, and the uptake of FRAX. Additional efforts are required to decrease the existing treatment gap estimating 75–90% of patients do not receive pharmacological intervention for secondary prevention, and the diagnosis rate is around 25%.

Methods
A selected panel of Turkish experts in fields related to osteoporosis was provided with a series of relevant questions to address prior to the multi-day conference. Within this conference, each narrative was discussed and edited by the entire group, through numerous drafts and rounds of discussion until a consensus was achieved. Represented in the panel were a number of societies including The Turkish Osteoporosis Society, The Society of Endocrinology and Metabolism of Turkey (SEMT), and The Turkish Society of Physical Medicine and Rehabilitation.

Results
Standardized general guidelines to identify OP and related fractures and at-risk population in Turkey, which will enable clinicians to accurately and effectively diagnose the disease, treat the appropriate patients with available pharmacological and non-pharmacological treatments and decrease the burden of the disease.

Conclusions
This manuscript provides a review of the current state of OP and related fractures in Turkey. Moreover, this manuscript reviews current international guidelines and national studies and proposes a number of helpful country-specific classifications that can be used by healthcare providers caring for the at-risk population. Additionally, the panel proposes practical recommendations that should be implemented nationally in order to decrease the burden of OP and related fractures and effectively preventing the burden in future generations.
Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis
Authors: Yoshida Reiko 
Published: August 2020

AbstractBreast cancer is a common cancer affecting a large number of patients. Notably, 5–10% of all breast cancer patients are genetically predisposed to cancers. Although the most common breast cancer susceptibility genes areBRCA1andBRCA2, which are also associated with the risk of developing ovarian and pancreatic cancer, advances in next-generation sequencing (NGS) analysis technology enabled the discovery of several non-BRCAgenes responsible for breast and ovarian cancers. Studies on hereditary breast and ovarian cancer (HBOC) involve not only determining the predisposition to developing cancer, but also considering the current treatment for breast cancer, prevention of next cancer, risk diagnosis, and adoption of protective measures for relatives. We present a comprehensive review of HBOC, which will be a useful resource in the clinical setting. Many hereditary tumors, including HBOC, are syndromes characterized by the development of different types of cancer in succession. Taking advantage of knowing predisposition of susceptibility to cancer, it is important to continue and update cancer management protocols, which includes the adoption of preventive measures, countermeasures, and treatments, to accurately assess and prevent the impact of cancer on the quality of life of the next generation of patients.
Neurogenesis After Stroke: A Therapeutic Perspective
Authors: Rahman Abir A. , Amruta Narayanappa , Pinteaux Emmanuel , Bix Gregory J. 
Published: August 2020

AbstractStroke is a major cause of death and disability worldwide. Yet therapeutic strategies available to treat stroke are very limited. There is an urgent need to develop novel therapeutics that can effectively facilitate functional recovery. The injury that results from stroke is known to induce neurogenesis in penumbra of the infarct region. There is considerable interest in harnessing this response for therapeutic purposes. This review summarizes what is currently known about stroke-induced neurogenesis and the factors that have been identified to regulate it. Additionally, some key studies in this field have been highlighted and their implications on future of stroke therapy have been discussed. There is a complex interplay between neuroinflammation and neurogenesis that dictates stroke outcome and possibly recovery. This highlights the need for a better understanding of the neuroinflammatory process and how it affects neurogenesis, as well as the need to identify new mechanisms and potential modulators. Neuroinflammatory processes and their impact on post-stroke repair have therefore also been discussed.
An integrated procedure for reservoir connectivity study between neighboring fields
Authors: Qassamipour Mehdi , Khodapanah Elnaz , Tabatabaei-Nezhad Seyyed Alireza 
Published: August 2020

AbstractReservoir connectivity has a considerable effect on reservoir characterization, plans for field developments and production forecasts. Reducing the uncertainties about the lateral and vertical extension of different pay zones is the main step in developing and managing the reservoirs. Nearly all the proposed methodologies for the verification of reservoir connectivity are limited to the study of the communication of different compartments in one field. In the presented paper, first a comprehensive procedure is proposed to study the reservoir connectivity between nearby fields. The steps in this procedure are not necessarily hierarchy, but all the considerations in each step are studied to cover all the uncertainties that affect the reservoir communication. This procedure mainly comprises the study of reservoir extension, pressure communication in the hydrocarbon column, fluid similarity, top seal efficiency and faults sealing. Then, to apply this procedure for proving the communication between nearby fields, a case study of Ilam Formation in southwest of Iran is presented. The results confirm the lateral connectivity of the three pre-explored distinctive oil fields in Ilam Formation. The established connectivity leads to an increase in the pre-estimated oil-in-place volumes. This incorporated case study demonstrates how different data including geophysics, structural and petroleum geology, production and reservoir engineering are integrated to prove the communication of Ilam reservoir between these fields. This manifested technique is a powerful road map for other cases worldwide and is extremely recommended to be performed before developing those fields that are suspicious to lateral connectivity.