bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering the Pharmacological of Xiaochaihu Decoction in the Treatment of Pancreatitis Based on the Network Pharmacology
Authors: Zhan Lianghui , Pu Jinbao , Hu Yijuan , Xu Pan , Liang Weiqing , Ji Chunlian 
Published: November 2020

Abstract
BackgroundXiaochaihu Decoction (XD) has been demonstrated the pharmacodynamic on pancreatitis. This study was aimed to investigate the material and molecular basis of Xiaochaihu Decoction.MethodsFirstly, compounds of seven herbs containing XD were collected from TCMSP Database and the putative targets of Pancreatitis were obtained from OMIM, TTD, Genecards Database. Then PPI network was constructed according to the matching results between XD potential targets and pancreatic neoplasms targets. Furthermore, enrichment analysis on GO and KEGG by DAVID utilized bioinformatics resources. Finally, Molecular Docking was performed to simulate the interaction between the active compound of XD and putative targets. In vitro experiment, AR42J cells were induced by LPS and then treated with Quercetin (25, 50, 100 μM). The IL-6, TNF-α, IL-1β levels were detected by Elisa kit and MAPK3, TP53 mRNA expressions were measured by RT-PCR.ResultsA total of 196 active ingredients and 91 putative targets were selected out. The PPI interaction network analysis demonstrated that Quercetin was the candidate agents and MAPK3, IL-6 and TP53 were the potential targets for the XD treatment of pancreatitis. The KEGG analysis revealed that pathways in cancers, TNF signaling way, MAPK signaling way might play an important role in pancreatitis therapy. And Molecular Docking results showed that Quercetin combined well with MAPK3, IL-6 and TP53. In vitro experiment indicated that, Quercetin inhibited the IL-6, TNF-α, IL-1β levels and MAPK3, TP53 mRNA. ConclusionThis study illustrated that Quercetin containing in XD might played an important role in pancreatitis therapy by acting the key genes of MPAK3, IL-6 and TP53 which were associating with inflammation and apoptosis.
Breastfeeding and Stress in Children
Authors: Ludvigsson Johnny , Faresjö Åshild , Faresjö Tomas 
Published: November 2020

Abstract
ObjectiveRepeated serious stress e.g. repeated serious life events or chronic stress may contribute to increased morbidity. One of the most important protective health factors for children is breast-feeding, but the mechanisms for this effect are not fully elucidated. Our objective was to assess if the duration of breastfeeding actually could influence degree of stress of children still at school-age. MethodsA random sample of 126 children from the ABIS-study, a prospective population-based child cohort study in southeast of Sweden was included. We had registered duration of breastfeeding and a number of psycho-social factors related to breast-feeding and/or stress. As a biomarker of stress we measured the child´s cortisol in hair at 8 years of age.ResultsWe found a negative correlation (r= -0.23, p=0.009) between total duration of breastfeeding and hair cortisol levels. In a multivariate analysis this association persisted (p=0.006) even when adjusted for other potential intervening factors like age of mother at delivery and early psychosocial vulnerability in the family, an index based on 12 factors.ConclusionA long breastfeeding seems to decrease stress many years later in children. This is a reason to facilitate for mothers to breast-feed their children, also in the modern society where women are expected to have a professional life.
Change of Gait After Unilateral Vestibular Neuritis: A Prospective Longitudinal Observation Study
Authors: Chae Sung-Won , Song Jae-Jun , Kim Woo-Sub 
Published: November 2020

Abstract
Background: Although symptoms of unilateral vestibular neuritis (uVN) resolve spontaneously and quickly, there are uncertainties in the recovery of gait function. There is lack of prospective longitudinal study for gait function after acute uVN. In addition, there is no report for longitudinal changes in medio-lateral stability during gait after uVN. Therefore, the present study tested time effects on spatio-temporal parameters and on the medio-lateral CoM-CoP relationship. In addition, we explored differences of gait metrics between uVN and controls. Methods: This is a prospective longitudinal observation study. Of 122 participants with vestibular symptoms, 23 participants with uVN and 20 controls were included in data analysis. 3D gait analysis, dizziness handicap inventory (DHI) and computerized dynamic posturography (CDP) were conducted 3 times after uVN onset: the 1st test was conducted within 2weeks after onset, 2nd test after 1 month of 1st test and 3rd test after 1 month of 2nd test. From gait analysis data, spatio-temporal parameters, inclination angle in frontal plane (IA) and variability of IA were obtained. Time effects on gait metrics were tested with linear mixed model.Results: Walking speed improved significantly between the 1st and 3rd test but they were within normal range, even at the 1st test. Step width was significantly larger than control at the 1st test and improved to normal at the 2nd test. IA did not show significant difference between uVN and control. Variability of IA in the affected side was significantly larger than that in controls at the 1st test and improved significantly at the 3rd test compared to the 1st test. Conclusions: Improvement of overall gait function and neural adaptation of medio-lateral stability during gait continued during recovery stage of uVN (after 2 months of onset). Vestibular rehabilitation for gait should be continued during recovery stage of uVN to enhance appropriate adaptation.
Kuwanons, Promising inhibitors against the ACE-2, main protease of SARS-CoV-2 and falcipan-2 using molecular docking
Authors: Kumari Kamlesh , Kumar Durgseh , Kumar Ramappa Venkatesh , Singh Prashant 
Published: November 2020

Abstract
In the present scenario, the COVID-19 has affected the nations throughout the world. Till date, neither a vaccine nor a potential medicine is available for the cure from SARS-CoV-2 infection. Main protease of SARS-CoV-2 is responsible for the replication and transcription. Further, this virus binds to the angiotensin converting enzyme-2 (ACE-2) so there is need to find molecule, to avoid the binding of novel virus to ACE-2. It is reported that the molecules binds to falcipan-2 can help in the reduction of infection due to SARS-CoV-2. Therefore, there is a need to find promising candidate against the receptors, spread COVID-19. In the present work, kuwanons are proposed to be promising candidates against the main protease of SARS-CoV-2, ACE-2 and falcipan-2. The interaction between the different kuwanons with different receptors has been studied using the binding energy. Kuwanon M was found to best inhibitor against the main protease of SARS-CoV-2 and ACE-2. Further, the drug-likeness properties of all the 16 kuwanons were studied. Kuwanon-M found to be best inhibitor against the ACE-2 and main protease of SARS-CoV-2 with binding energy of -165.349 and -149.952 kcal/mol respectively while kuwanon-G found out to promising against the falcipan-2 with a binding energy of -149.573 kcal/mol.
COVID-19 scaling dynamics in growth and decline phases
Authors: Schertzer Daniel , Tchiguirinskaia Ioulia 
Published: November 2020

Abstract
The definition of optimal COVID-19 mitigation strategies remains worldwide on the top of public health agendas, particularly when facing a second wave. It requires a better understanding and a refined modelling of its dynamics. We emphasise the fact that epidemic models are phenomenologically based on the paradigm of a cascade of contacts that propagates infection. However, the introduction of ad-hoc characteristic times and corresponding rates spuriously break their scale symmetry.Here we theoretically argue and empirically demonstrate that COVID-19 dynamics, during both growth and decline phases, is a cascade with a rather universal scale symmetry whose power-law statistics drastically differ from those of an exponential process. This involves slower but longer phases which are furthermore linked by a fairly simple symmetry. These results explain biases of epidemic models and help to improve them. Due to their generality, these results pave the way to a renewed approach to epidemics, and more generally to growth phenomena.
Agricultural Grain Markets in the COVID-19 Crisis, Insights From a GVARModel
Authors: Gutierrez Luciano , Pierre Guillaume 
Published: November 2020

Abstract
The objective of this paper is to combine cross-commodity and spatial price transmission analysis to study the dynamics of the global cereal feed market during the COVID-19 pandemic. After reviewing the nascent literature on the impact of COVID-19 on agricultural markets, we discuss the different impact channels on prices. Then we provide stylized market reactions of three relevant feed markets, wheat, barley and maize to a set of simulated possible future shocks on oil prices, stock-to-use ratios, and export restrictions. These three shocks are useful to assess what could be the consequences of policy responses to the COVID-19 (export restrictions) or disruptions due to the virus (stock-to-use reductions), in a context of lower oil prices. To generate these market reactions, we use a Global Vector Auto Regression (GVAR) model (Dees et al., 2007) where each market is modelled independently, and connected through trade based composite variables. We expand the work of Gutierrez et al. (2015) on the global wheat market by introducing maize and barley. The results of the empirical analysis indicate that the fall in the oil price may have contributed to the stability of the world grain market in early 2020, despite fears of supply chain disruption. We also note that export restrictions could significantly increase global prices, and that such restrictions could affect more than the targeted commodity, through significant cross-commodity price linkages.
Metabolomic profiling on plasma reveals potential biomarkers for screening and early diagnosis of intestinal-type gastric cancer and precancerous stages
Authors: Du Lijing , Li Shasha , Xiao Xue , Li Jin , Jin Huizi , Hua Zhaolai , Ma Juming , Wang Xi , Yan Shikai 
Published: November 2020

Abstract
Background: Gastric cancer (GC) with majority of intestinal-type adenocaricinoma remains one of the most common cancers all over the world. GC faces a great challenge in the clinical diagnosis, that it often can be detected at advanced stages, and leads to the loss of optimum time for treatment and poor prognosis. Thus, there is a critical need to develop effective and noninvasive strategies for early diagnosis of the disease process. Methods: Totally, 82 participants were enrolled in the study, including 50 chronic superficial gastritis (CSG) patients, 7 intestinal-type early gastric cancer (EGC) and 25 intestinal-type advanced gastric cancer (AGC) ones. Metabolites profiling on patient plasma was performed using ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Principal components analysis, orthogonal partial least squares-discriminant analysis as well as Random Forest were utilized to evaluate the variation on endogenous metabolites for intestinal-type GC patients and to screen potential biomarkers. Furthermore, the proposed biomarkers were used to create logistic regression models, which discrimination efficiency and accuracy was ascertained by receiver operating characteristic curve (ROC) analysis. Metabolic pathway analysis was carried out on MetaboAnalyst.Results: Totally 50 metabolites were detected with differentially expression among CSG, intestinal-type EGC and AGC patients. L-carnitine, L-proline, pyruvaldehyde, phosphatidylcholines (PC) (14:0/18:0), lysophosphatidylcholine (14:0) (LysoPC 14:0), lysinoalanine were defined as the potential biomarker panel for the diagnosis among CSG and EGC patients. Compared with EGC patients, 6 significantly changed metabolites, PC(O-18:0/0:0) and LysoPC(20:4(5Z,8Z,11Z,14Z)) were found to be up-regulated in AGC patients, whereas L-proline, L-valine, adrenic acid and pyruvaldehyde down-regulated. ROC analysis demonstrated a high diagnostic performance for metabolite panels with area under the curve (AUC) of 0.931 to 1. Moreover, the metabolomic pathway analysis revealed several metabolism pathway disorders, including amino acid and lipid metabolisms, in intestinal-type GC patients.Conclusions: In this study, a total of six metabolites were identified to contribute significantly to the diagnosis of intestinal-type GC and precancerous stages, respectively, and over 93.1% AUC value was achieved in AUC test on biomarker panels. It indicated that the biomarker panels are sensitive to the early diagnosis of intestinal-type GC disease, which is expected to be developed as a promising diagnostic and prognostic tool for disease stratification studies.
Survival of patients with appendiceal neuroendocrine tumors: whether they benefit from right hemicolectomy?
Authors: Lin Haiping , Wang Liyuan , Bai Yang , Ge Chenyang , Zheng Hongjuan , Yu Shian 
Published: November 2020

Abstract
Background: Current guidelines recommend right hemicolectomy for appendiceal neuroendocrine tumors (A-NETs) patients with lymph node (LN) metastasis. However, prognosis of these patients is favorable, and the prognostic impact of metastatic LN is controversial.Objective: The study aims to evaluate the prognostic factors of A-NETs, and explore whether right hemicolectomy/ more extended procedure (RHCM) improves prognosis compared to less extended than right hemicolectomy (LRHC).Methods: Patients with A-NETs were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The Fine-Gray proportional hazards model was established to calculate subdistribution hazard ratios of prognostic factors. A propensity score matching was performed to balance intergroup differences between the LRHC and RHCM groups, and survival difference between the after-matched groups was tested using the Gray test. Subgroup analyses were also conducted.Results: In the multivariate analysis, histological type and distant metastatic status were associated with prognosis, while tumor size and nodal status were not. After propensity score matching, the patients’ characteristics were well balanced. RHCM did not confer survival benefits in the whole after-matched patients or any subgroup.Conclusions: Metastatic LN does not significantly impact prognosis, and RHCM fails to improve prognosis compared to LRHC. Therefore, the current “LN-decided” surgical procedure may not be suitable for patients with A-NETs.
Bayesian response adaptive randomization in clinical trials with a time-trend: application to a real trial
Authors: Jiang Yunyun , Zhao Wenle , Durkalski-Mauldin Valerie 
Published: November 2020

Abstract
Background: In clinical trials with a large sample size, time-trend in response rates can affect the performance of Bayesian response adaptive randomization (BRAR).Methods: To evaluate this impact, we utilize data from a previously completed randomized controlled trial that used a fixed 1:1 allocation. Subject response data from this study demonstrate a clear time-trend in the control group, but not in the treatment group. In this simulation study, we re-assign patients to treatment groups based on a BRAR algorithm, to examine the performance of BRAR as measured by the treatment effect estimation, the probability of early stopping, and the shift in adaptive allocation.Results: Results from specific simulated study scenario show that in the presence of a time-trend, the timing of the first interim analysis is critical for the efficacy/futility decision making. Compared with fixed equal allocation, BRAR results in a higher probability of premature early stopping when time-trend effect exists. The magnitude of such impact varies among different BRAR algorithms.Conclusions: Influential factors such as time trend, should be considered when planning the implementation of BRAR in large trials.Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00235495. Registered on October 10, 2005.
QTL detection for bread wheat processing quality in a nested association mapping population of semi-wild and domesticated wheat varieties
Authors: Hu Junmei , Xiao Guilian , Jiang Peng , Zhao Yan , Zhang Guangxu , Ma Xin , Yao Jie , Xue Lixia , Su Peisen , Bao Yinguang 
Published: November 2020

Abstract
Background: Wheat processing quality is an important factor in evaluating overall wheat quality and dough characteristics are important in assessing the processing quality of wheat. As an important germplasm resource, semi-wild wheat plays an important role in the study of wheat processing quality.Results: In this study, four dough rheological characteristics were therefore collected in four environments using a nested association mapping (NAM) population, consisting of semi-wild and domesticated wheat varieties, which was used to identify quantitative trait loci (QTL) for wheat processing quality. A total of 49 QTL for wheat processing quality were detected, explaining 0.36–10.82% of the phenotypic variation. These QTL were located on all wheat chromosomes except for 2D, 3A, 3D, 6B, 6D and 7D. Compared to previous studies, 29 QTL were newly identified. Four novel QTL, QMlPH-1B.4, QMlPH-3B.4, QWdEm-1B.2 and QWdEm-3B.2, were stably identified in three or more environments, of which QMlPH-3B.4 was a major QTL. Moreover, eight important genetic regions for wheat processing quality were identified on chromosomes 1B, 3B and 4D, which showed pleiotropy for dough characters. In addition, out of 49 QTL, 15 favorable alleles came from three semi-wild parents, suggesting that the QTL alleles provided by the semi-wild parent were unutilized in domesticated varieties.Conclusions: The results show that the semi-wild wheat varieties can enrich the existing wheat gene pool and provide broader variation resources for wheat genetic research.
Benefits of Resistance Training in Older Adults
Authors: Syed-Abdul Majid Mufaqam 
Published: November 2020

Abstract::
Aging is a natural process that may lead to detrimental health depending on someone’s
lifestyle, family history, psychological/psychosocial health, chronic medical conditions, and genetics.
However, whether the later conditions lead to faster aging or vice versa, maintaining a healthy
lifestyle and psychological health has been shown to delay the process of aging and its associated
problems. Two major problems that older adults face today are the inability to perform everyday
tasks (defined as activities of daily living) and the increased risk of falls. Lack of muscular function
(including neuromuscular function) and bone health is associated with the inability to perform
the Activity of Daily Living (ADL) and increased risk of falls. This risk of falls has been associated
with cardiovascular-related mortality in older adults. Research has shown that resistance exercises
can maintain normal blood glucose levels, lipids, and cholesterol, and hence the management of
chronic conditions like cardiovascular diseases and diabetes mellitus. Additionally, resistance exercises
hinder the process of muscular (and neuromuscular) damage, improve bone health and psychological
health and sleep. This mini-review will discuss the benefits of resistance exercises on reversing
or at least ceasing the process of developing conditions associated with aging.
Efektivitas metode pembelajaran PQ4R ditinjau dari kemampuan berpikir reflektif matematis dan self-concept siswa
Authors: Permatasari Intan , Noer Sri Hastuti , Gunowibowo Pentatito 
Published: November 2020

Penelitian eksperimen semu ini bertujuan untuk menguji efektivitas metode pembelajaran PQ4R (Preview, Question, Read, Reflect, Recite, Review) ditinjau dari kemampuan berpikir reflektif dan self-concept siswa. Populasi penelitian adalah seluruh siswa kelas VIII SMP Negeri 12 Bandar Lampung tahun pelajaran 2019/2020 yang terdistribusi dalam sembilan kelas. Dari sembilan kelas tersebut dipilih satu kelas sebagai kelas eksperimen dan satu kelas sebagai kelas kontrol. Desain penelitian yang digunakan adalah pretest-posttest control group design. Pengumpulan data dilakukan menggunakan tes kemampuan berpikir reflektif matematis dan angket self-concept siswa. Data hasil tes dan angket dianalisis secara deskriptif dan inferensial. Hasil penelitian menunjukkan bahwa persentase siswa pada kelas PQ4R dengan kemampuan berpikir reflektif matematis dan self-concept terkategori baik lebih dari 60% dari jumlah siswa, namun peningkatan kemampuan berpikir reflektif matematis dan self-concept siswa yang mengikuti pembelajaran PQ4R tidak lebih tinggi daripada peningkatan siswa yang mengikuti pembelajaran konvensional. Dengan demikian, dapat disimpulkan bahwa metode pembelajaran PQ4R tidak efektif ditinjau dari kemampuan berpikir reflektif matematis dan self-concept siswa. The effectiveness of the PQ4R learning method in terms of students' mathematical reflective thinking ability and self-conceptAbstractThis quasi-experimental research aimed to examine the effectiveness of the PQ4R (Preview, Question, Read, Reflect, Recite, Review) learning method in terms of reflective thinking ability and self-concept of students. The study population was all eighth-grade students of SMP Negeri 12 Bandar Lampung (Junior High School) for the 2019/2020 academic year, distributed in nine classes. Of the nine classes, one class was selected as the experimental class and one class as the control class. The research design used was the pretest-posttest control group design. The data was collected using a test of reflective mathematical thinking skills and a students' self-concept questionnaire. Test and questionnaire results were analyzed descriptively and inferentially. The results showed that the percentage of students in the PQ4R class with good categories in reflective mathematical thinking and self-concept was more than 60% of students' total number. The increase in mathematical reflective thinking ability and self-concept of students who took PQ4R learning was not higher than the increase in students who follow conventional learning. Thus, it can be concluded that the PQ4R learning method was ineffective in terms of students’ mathematical reflective thinking skills and self-concept.