bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐Photon Excitation Followed by a Three‐Step Sequential Energy–Energy–Electron Transfer Leading to a Charge‐Separated State in a Supramolecular Tetrad Featuring Benzothiazole–Boron‐Dipyrromethene–Zinc Porphyrin–C60
Authors: Badgurjar Deepak , Seetharaman Sairaman , D'Souza Francis , Chitta Raghu 
Published: October 2020

AbstractA panchromatic triad, consisting of benzothiazole (BTZ) and BF2‐chelated boron‐dipyrromethene (BODIPY) moieties covalently linked to a zinc porphyrin (ZnP) core, has been synthesized and systematically characterized by using 1H NMR spectroscopy, ESI‐MS, UV‐visible, steady‐state fluorescence, electrochemical, and femtosecond transient absorption techniques. The absorption band of the triad, BTZ‐BODIPY‐ZnP, and dyads, BTZ‐BODIPY and BODIPY‐ZnP, along with the reference compounds BTZ‐OMe, BODIPY‐OMe, and ZnP‐OMe exhibited characteristic bands corresponding to individual chromophores. Electrochemical measurements on BTZ‐BODIPY‐ZnP exhibited redox behavior similar to that of the reference compounds. Upon selective excitation of BTZ (≈290 nm) in the BTZ‐BODIPY‐ZnP triad, the fluorescence of the BTZ moiety is quenched, due to photoinduced energy transfer (PEnT) from 1BTZ* to the BODIPY moiety, followed by quenching of the BODIPY emission due to sequential PEnT from the 1BODIPY* moiety to ZnP, resulting in the appearance of the ZnP emission, indicating the occurrence of a two‐step singlet–singlet energy transfer. Further, a supramolecular tetrad, BTZ‐BODIPY‐ZnP:ImC60, was formed by axially coordinating the triad with imidazole‐appended fulleropyrrolidine (ImC60), and parallel steady‐state measurements displayed the diminished emission of ZnP, which clearly indicated the occurrence of photoinduced electron transfer (PET) from 1ZnP* to ImC60. Finally, femtosecond transient absorption spectral studies provided evidence for the sequential occurrence of PEnT and PET events, namely, 1BTZ*‐BODIPY‐ZnP:ImC60→BTZ‐1BODIPY*‐ZnP:ImC60→BTZ‐BODIPY‐1ZnP*:ImC60→BTZ‐BODIPY‐ZnP.+:ImC60.− in the supramolecular tetrad. The evaluated rate of energy transfer, kEnT, was found to be 3–5×1010 s−1, which was slightly faster than that observed in the case of BODIPY‐ZnP and BTZ‐BODIPY‐ZnP, lacking the coordinated ImC60. The rate constants for charge separation and recombination, kCS and kCR, respectively, calculated by monitoring the rise and decay of C60.− were found to be 5.5×1010 and 4.4×108 s−1, respectively, for the BODIPY‐ZnP:ImC60 triad, and 3.1×1010 and 4.9×108 s−1, respectively, for the BTZ‐BODIPY‐ZnP:ImC60 tetrad. Initial excitation of the tetrad, promoting two‐step energy transfer and a final electron‐transfer event, has been successfully demonstrated in the present study.
A pH‐Induced Reversible Conformational Switch Able to Control the Photocurrent Efficiency in a Peptide Supramolecular System
Authors: Kubitzky Sascha , Venanzi Mariano , Biondi Barbara , Lettieri Raffaella , De Zotti Marta , Gatto Emanuela 
Published: October 2020

AbstractExternal stimuli are potent tools that Nature uses to control protein function and activity. For instance, during viral entry and exit, pH variations are known to trigger large protein conformational changes. In Nature, also the electron transfer (ET) properties of ET proteins are influenced by pH‐induced conformational changes. In this work, a pH‐controlled, reversible 310‐helix to α‐helix conversion (from acidic to highly basic pH values and vice versa) of a peptide supramolecular system built on a gold surface is described. The effect of pH on the ability of the peptide SAM to generate a photocurrent was investigated, with particular focus on the effect of the pH‐induced conformational change on photocurrent efficiency. The films were characterized by electrochemical and spectroscopic techniques, and were found to be very stable over time, also in contact with a solution. They were also able to generate current under illumination, with an efficiency that is the highest recorded so far with biomolecular systems.
Glycine‐Functionalized CsPbBr3 Nanocrystals for Efficient Visible‐Light Photocatalysis of CO2 Reduction
Authors: Xu Ying , Zhang Wen , Su Ke , Feng You‐Xiang , Mu Yan‐Fei , Zhang Min , Lu Tong‐Bu 
Published: October 2020

AbstractCapping ligands are indispensable for the preparation of metal‐halide‐perovskite (MHP) nanocrystals (NCs) with good stability; however, the long alkyl‐chain capping ligands in conventional MHP NCs will be unfavorable for CO2 adsorption and hinder the efficient carrier separation on the surface of MHP NCs, leading to inferior catalytic activity in artificial photosynthesis. Herein, CsPbBr3 nanocrystals with short‐chain glycine as ligand are constructed through a facile ligand‐exchange strategy. Owing to the reduced hindrance of glycine and the presence of the amine group in glycine, the photogenerated carrier separation and CO2 uptake capacity are noticeably improved without compromising the stability of the MHP NCs. The CsPbBr3 nanocrystals with glycine ligands exhibit a significantly increased yield of 27.7 μmol g−1 h−1 for photocatalytic CO2‐to‐CO conversion without any organic sacrificial reagents, which is over five times higher than that of control CsPbBr3 NCs with conventional long alkyl‐chain capping ligands.
Prevalence of atrial fibrillation dependent on coronary artery status: Insights from theLIFE‐HeartStudy
Authors: Kornej Jelena , Henger Sylvia , Seewöster Timm , Teren Andrej , Burkhardt Ralph , Thiele Holger , Thiery Joachim , Scholz Markus 
Published: October 2020

AbstractBackgroundCoronary artery disease (CAD) is a significant risk factor for atrial fibrillation (AF). Experimental studies demonstrated that atrial ischemia induced by right coronary artery (RCA) stenosis promote AF triggers and development of electro‐anatomical substrate for AF.AimTo analyze the association between AF prevalence and coronary arteries status in the LIFE‐Heart Study.MethodsThis analysis included patients with available coronary catheterization data recruited between 2006 and 2014. Patients with acute myocardial infarction were excluded. CAD was defined as stenosis ≥75%, while coronary artery sclerosis (CAS) was defined as non‐critical plaque(s) <75%.ResultsIn total, 3.458 patients (median age 63 years, 34% women) were included into analysis. AF was diagnosed in 238 (6.7%) patients. There were 681 (19.7%) patients with CAS and 1.411 (40.8%) with CAD (27.5% with single, 32.4% with double, and 40.1% with triple vessel CAD). In multivariable analysis, there was a significant association between prevalent AF and coronary artery status (OR 0.64, 95% CI 0.53‐0.78,Ptrend < .001). Similarly, AF risk was lower in patients with higher CAD extent (OR 0.54, 95%CI 0.35‐0.83,Ptrend= .005). Compared to single vessel CAD, the risk of AF was lower in double (OR 0.42, 95%CI 0.19‐0.95,P= .037) and triple CAD (OR 0.31, 95%CI 0.13‐0.71,P= .006). Finally, no association was found between AF prevalence and CAD origin among patients with single vessel CAD.ConclusionIn the LIFE‐Heart Study, CAS but not CAD was associated with increased risk of AF.
Quantifying treatment preferences and their association with financial toxicity in women with breast cancer
Authors: Williams Courtney P. , Gallagher Kathleen D. , Deehr Katie , Aswani Monica S. , Azuero Andres , Daniel Casey L. , Ford Eric W. , Ingram Stacey A. , Balch Alan J. , Rocque Gabrielle B. 
Published: October 2020

BackgroundThe objective of the current study was to understand treatment preferences and their association with financial toxicity in Patient Advocate Foundation clients with breast cancer.MethodsThis choice‐based conjoint analysis used data from a nationwide sample of women with breast cancer who received assistance from the Patient Advocate Foundation. Choice sets created from 13 attributes of 3 levels each elicited patient preferences and trade‐offs. Latent class analysis segmented respondents into distinct preference archetypes. The Comprehensive Score for Financial Toxicity (COST) tool captured financial toxicity. Adjusted generalized linear models estimated COST score differences by preference archetype.ResultsOf 220 respondents (for a response rate of 10%), the median age was 58 years (interquartile range, 49‐66 years); 28% of respondents were Black, indigenous, or people of color; and approximately 60% had household incomes <$40,000. The majority of respondents were diagnosed with early‐stage cancer (91%), 38% had recurrent disease, and 61% were receiving treatment. Treatment choice was most affected by preferences related to affordability and impact on activities of daily living. Two distinct treatment preference archetypes emerged. The “cost‐prioritizing group” (75% of respondents) was most concerned about affordability, impact on activities of daily living, and burdening care partners. The “functional independence–prioritizing group” (25% of respondents) was most concerned about their ability to work, physical side effects, and interference with life events. COST scores were found to be similar between the archetypes in adjusted models (cost‐prioritizing group COST score, 12 [95% confidence interval, 9‐14]; and functional independence–prioritizing COST score, 11 [95% confidence interval, 9‐13]).ConclusionsPatients with breast cancer prioritized affordability or maintaining functional independence when making treatment decisions. Because of this variability, preference evaluation during treatment decision making could optimize patients' treatment experiences.
Defect Engineering on Boron Nitride for O2 Activation and Subsequent Oxidative Desulfurization
Authors: Lv Naixia , Yin Jie , Fu Wendi , Zhang Jinrui , Li Yujun , Jiang Ding , Li Hongping , Zhu Wenshuai 
Published: October 2020

AbstractThe rational design of highly active hexagonal boron nitride (h‐BN) catalysts at the atomic level is urgent for aerobic reactions. Herein, a doping impurity atom strategy is adopted to increase its catalytic activities. A series of doping systems involving O, C impurities and B, N antisites are constructed and their catalytic activities for molecular O2 have been studied by density functional theory (DFT) calculations. It is demonstrated that O2 is highly activated on ON and BN defects, and moderately activated on CB and CN defects, however, it is not stable on NB and OB defects. The subsequent application in oxidative desulfurization (ODS) reactions proves the ON and C‐doped (CB, CN) systems to be good choice for sulfocompounds oxidization, especially for dibenzothiophene (DBT). While the BN antisite is not suitable for such aerobic reaction due to the extremely stable B−O*−B species formed during the oxidation process.
Roadsides provide refuge for orchids: characteristic of the surrounding landscape
Authors: Fekete Réka , Bódis Judit , Fülöp Bence , Süveges Kristóf , Urgyán Renáta , Malkócs Tamás , Vincze Orsolya , Silva Luís , Molnár V. Attila 
Published: October 2020

AbstractSeminatural habitats are declining throughout the world; thus, the role of small anthropogenic habitats in the preservation of plants is becoming increasingly appreciated. Here, we surveyed the orchid flora of roadside verges in five Central European countries (Austria, Hungary, Romania, Slovakia, and Slovenia) and tested how the surrounding landscape matrix affects the overall number of species and individuals, and also different functional groups of orchids. We found more than 2,000 individuals of 27 orchid species during our surveys. According to our results, the increasing coverage of agricultural and urban areas negatively affects both the number of orchid species and individuals on roadsides. Our study further suggests that differences in the surrounding habitats affect which species are found on roadsides, since the increasing coverage of grasslands or forested areas around orchid occurrences had a significant positive effect on the number of grassland or forest‐dwelling species and individuals, respectively. Most variance in orchid numerosity and diversity was explained by the cover of the suitable habitat types of the respective taxa in the surrounding landscape of the sampling points. This highlights the importance of roadsides acting as refugia for numerous species and valuable plant communities as well as in supporting biodiversity in general.
A novel single‐wire communication method using analog wave for a universal connector
Authors: Tanno Yoshinobu , Hayashi Takafumi 
Published: October 2020

AbstractVarious devices such as computer and peripheral device contribute to our lives. Because there is a wide variety of devices, the types of device connector standard are increasing. A converter for converting the electrical signal of the pin in a connector is required for communication with different connector standard. However, there is a problem that the number of converters for interconnection continues to increase when the connector standard continues to increase. This paper proposes a communication method for the universal connector that can automatically communicate between different connector standards without the converter. The universal connector negotiates at the beginning of the connection using the electrical signal of the pin in the connector. The negotiation using the electrical signal of the pin requires a single‐wire communication. Machine with single‐wire communication requires to understand connection partner's performance because available machines with the universal connector do not strictly limit the partner. In this paper, we propose a novel single‐wire communication method that each machine understands performance of connection partner for the universal connector. The performance of the proposed method was evaluated by simulation.
Cost‐effectiveness of adding dapagliflozin to standard treatment for heart failure with reduced ejection fraction patients in China
Authors: Yao Younan , Zhang Rongcheng , An Tao , Zhao Xinke , Zhang Jian 
Published: October 2020

AbstractAimsThis study was to determine the cost‐effectiveness of dapagliflozin in heart failure with reduced ejection fraction (HFrEF) patients in China from a perspective of health care payers.Methods and resultsWe built a Markov model to perform a cost‐effectiveness analysis comparing standard treatment + dapagliflozin (10 mg, q.d.) with standard treatment for HFrEF. The base case in our simulation was a 65‐year‐old HFrEF patient and was modelled over 15 years. Inputs of the model were derived from the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial and other relevant data from China. Costs, quality‐adjusted life year (QALY), and incremental cost‐effectiveness ratio (ICER) were estimated for adding dapagliflozin relative to standard treatment. Costs and QALY were discounted at a 4.2% rate annually. All costs are presented in 2017 US dollars. Dapagliflozin would be considered very cost‐effective if the ICER was lower than a willingness‐to‐pay (WTP) threshold of $8573.4. Uncertainty was assessed in our model using one‐way, two‐way, and probabilistic sensitivity analysis (PSA). In our base case, compared with standard treatment, adding dapagliflozin was more expensive ($5829.4 vs. $4377.1) but more effective (4.82 vs. 4.44 QALYs). The respondent ICER was $3827.6 per QALY gained at 15‐year follow‐up. When the simulated horizon was longer than 3.5 years, the respondent ICER became lower than the WTP threshold. The inputs with the largest impact on ICER were the cost of dapagliflozin, the cardiovascular mortality in both groups, and the cost of hospitalization for heart failure. Most results of sensitivity analysis were robust. PSA showed a similar result as the base case (ICER = $4412.5 per QALY gained). In Monte Carlo simulation, at a WTP threshold of $8573.4 per QALY, dapagliflozin was considered very cost‐effective in 53.10% of the simulations.ConclusionsDapagliflozin was a very cost‐effective treatment option for HFrEF patients in China according to the result of our model. Our findings will help doctors and health care payers to make decisions in clinical practice. Future real‐world studies of cost‐effectiveness of dapagliflozin based on Chinese population were also needed.
MitraClip implantation followed by insertion of a left ventricular assist device in patients with advanced heart failure
Authors: Kreusser Michael M. , Hamed Sonja , Weber Andreas , Schmack Bastian , Volz Martin J. , Geis Nicolas A. , Grossekettler Leonie , Pleger Sven T. , Ruhparwar Arjang , Katus Hugo A. , Raake Philip W. 
Published: October 2020

AbstractAimsMitral valve regurgitation (MR) is common in patients with advanced heart failure (HF). Percutaneous mitral valve repair (PMVR) via MitraClip (MC) has emerged as a feasible treatment strategy for these high‐risk patients. However, as HF often further progresses, there is a frequent need for left ventricular assist device (LVAD) implantation in these patients. We aimed to investigate whether prior MC implantation affects the subsequent LVAD implantation and outcome.Methods and resultsThirty‐seven patients with advanced HF and significant MR who underwent LVAD implantation were retrospectively analysed. Follow‐up data were collected at 1 year after LVAD implantation. Primary endpoint was all‐cause mortality. Secondary endpoint included peri‐operative parameters and clinical development depicted as New York Heart Association (NYHA) class and Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) level. Seventeen patients initially received a MC device (MC group), resulting in a significant reduction in MR grade. After MC, NYHA class and INTERMACS level further worsened, leading to subsequent LVAD implantation after a median time of 475 days in the MC group. At LVAD implantation, overall characteristics were comparable with those of the patients undergoing LVAD implantation without prior MC placement (no‐MC group). Procedural data revealed a higher incidence of right ventricular (RV) failure needing mechanical RV assistance and a longer need for nitric oxide ventilation in the MC group after LVAD implantation. One‐year survival was slightly better in the no‐MC group compared with the MC group [41% (n = 7/17) vs. 65% (n = 13/20); P = 0.15], albeit event‐free survival was comparable between both groups, MC and no‐MC.ConclusionsLVAD implantation after MC is feasible and safe. However, in patients with advanced HF and severe MR, PMVR may only delay a needed LVAD implantation and thereby lead to poorer peri‐operative RV function and impaired outcome. Arguably, these patients might benefit from the timely management of advanced HF by the means of early LVAD implantation or heart transplantation.
Novel Designing of Chemically Modified Electrode (CME) of the Bio‐MOF‐1 for the Detection of Dopamine Based on Inhibition of [Ru(bpy)3]2+/DBAE System
Authors: Dong X. Y. , Zhang R. Z. , Zhang T. K. , Liu F. Y. 
Published: October 2020

AbstractMetal organic frameworks (MOFs) have attracted extensive attention in electrochemical research fields due to their high surface area and controlled porosity. Current study is design to investigate the ECL performance of the chemically modified electrode (CME) based on the bio‐MOF‐1, a porous zinc‐adenine framework, which loaded ruthenium complex and employed for the detection of dopamine (DA). The composite material [Ru(bpy)3]2+@bio‐MOF‐1 (Ru‐bMOF) modified carbon glassy electrode (Ru‐bMOF/GCE) exhibited an excellent ECL performance having a linear co‐efficient response (R2=0.9968) for 2‐(dibutyl amino) ethanol (DBAE), a classical ECL co‐reactant was obtained over a concentration range of 1.0×10−9 M to 1.0×10−4 M in 0.10 M pH=6.0 phosphate buffer solution (PBS). Furthermore, DA was detected based on its inhibition effect on [Ru(bpy)3]2+/DBAE system. Compared to traditional analytical methods, this method has various advantages such as simple electrode preparation, quick response, high reproducibility (RSD<2.0 %), low limit of detection (LOD=1.0×10−10 mol/L). This chemical investigated modified electrode had exploited potential for detection of DA.
Lactobacillus plantarum 06CC2 reduces hepatic cholesterol levels and modulates bile acid deconjugation in Balb/c mice fed a high‐cholesterol diet
Authors: Yamasaki Masao , Minesaki Mikako , Iwakiri Asuka , Miyamoto Yuko , Ogawa Kenjiro , Nishiyama Kazuo , Tsend‐Ayush Chuluunbat , Oyunsuren Tsendesuren , Li Yiran , Nakano Tomoki , Takeshita Masahiko , Arima Yuo 
Published: October 2020

AbstractPrevious study suggested that dietary intake of Lactobacillus plantarum 06CC2 (LP06CC2) isolated from Mongolian dairy products showed various health beneficial effects. Here, the effect of LP06CC2 on the cholesterol metabolism in mice fed a cholesterol‐loaded diet was evaluated. Cholesterol and LP06CC2 were incorporated into the AIN93G‐based diet to evaluate the effect on cholesterol metabolism in Balb/c mice. Serum and liver cholesterol levels were significantly increased in mice fed a cholesterol‐loaded diet whereas the LP06CC2 ingestion suppressed the increase of liver cholesterol. LP06CC2 suppressed the increase of the hepatic damage indices. The increase of the cecal content and fecal butyrate were observed in mice fed LP06CC2. The analysis of bile acids clearly showed that LP06CC2 increased their deconjugation indicating the decrease of bile acid absorption. The protein expression of hepatic Cyp7A1 was also suppressed by LP06CC2 in mice fed cholesterol. Finally, in vitro studies showed that LP06CC2 had the most potent ability to deconjugate bile acids using glycocholate among the tested probiotic lactic acid bacteria isolated from Mongolian dairy products. Taken together, LP06CC2 is a promising microorganism for the reduction of the cholesterol pool via modulation of bile acid deconjugation.
Hospital entrance smoking is reduced by broadcasting recorded antitobacco messages from Australian primary school children over entrance public address system
Authors: Webb Ashley , Tascone Belinda , Wickham Lucy , Webb Gemma , Wijeyaratne Avisha , Boyd David Thomas , Leong Samuel 
Published: October 2020

AbstractIssue addressedSmoking near hospital entrances occurs frequently despite smoke‐free policies, resulting in multiple issues including second‐hand smoke exposure (SHS) to vulnerable populations. Primary school children were engaged through their health curriculum to produce antismoking audio recordings for broadcast over a hospital entrance loudspeaker system to determine if this reduced smoking.MethodStudents produced original recordings against hospital grounds smoking during class workshops, from which a collection (n = 16) was selected. Episodes of entrance smoking and total entrance traffic were recorded using security camera infrastructure over a 5‐week period. A computer‐controlled entrance loudspeaker played a message which was followed by silence until a new (different) message was played. Intensity of messaging was moderate in week 3 (every 5 minutes), increasing to high in week 4 (3 minutely) and compared to no messages (weeks 1‐2 preintervention) and week 5 (postintervention).ResultsSmokers presented 316 times, smoking 523 cigarettes over 155 hours of observation (patients 70.6%, visitors 29.4%). SHS exposure was high given 172 others used the entrance/hour. Smoking was highest in the preintervention period (weeks 1‐2), median five cigarettes/hr [IQR,3‐7 (min = 0, max = 12)], falling to four cigarettes/hr during 5‐minutely broadcasts [IQR,2‐5 (min = 1, max = 14)] (P = .06), but zero cigarettes/hr during 3‐minutely broadcasts [IQR,0‐1(min = 0, max = 7)] (P < .0001). Postintervention (no broadcasts), smoking increased from zero to 1 cigarette/hr [IQR,0‐3 (min = 0, max = 5)]; (P = .052). Nonsmoker movements did not change significantly between each period.ConclusionIntensive (3 minutely) broadcasting of short antismoking messages significantly reduced hospital entrance smoking.So what?Health services can positively interact with the health curriculum of primary schools against tobacco use while developing low‐cost strategies to effectively deter entrance smoking.