bluuebunny/crossref_metadata_2025_split huggingface dataset:
β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia
Authors: Alzahrani Abdulaziz A. , Cao Lily L. , Aldossary Hayyaf S. , Nathanael Demitris , Fu Jiarong , Ray Clare J. , Brain Keith L. , Kumar Prem , Coney Andrew M. , Holmes Andrew P. 
Published: November 2020

AbstractCarotid body (CB) hyperactivity promotes hypertension in response to chronic intermittent hypoxia (CIH). The plasma concentration of adrenaline is reported to be elevated in CIH and our previous work suggests that adrenaline directly activates the CB. However, a role for chronic adrenergic stimulation in mediating CB hyperactivity is currently unknown. This study evaluated whether beta-blocker treatment with propranolol (Prop) prevented the development of CB hyperactivity, vascular sympathetic nerve growth and hypertension caused by CIH. Adult male Wistar rats were assigned into 1 of 4 groups: Control (N), N + Prop, CIH and CIH + Prop. The CIH paradigm consisted of 8 cycles h−1, 8 h day−1, for 3 weeks. Propranolol was administered via drinking water to achieve a dose of 40 mg kg−1 day−1. Immunohistochemistry revealed the presence of both β1 and β2-adrenoceptor subtypes on the CB type I cell. CIH caused a 2–3-fold elevation in basal CB single-fibre chemoafferent activity and this was prevented by chronic propranolol treatment. Chemoafferent responses to hypoxia and mitochondrial inhibitors were attenuated by propranolol, an effect that was greater in CIH animals. Propranolol decreased respiratory frequency in normoxia and hypoxia in N and CIH. Propranolol also abolished the CIH mediated increase in vascular sympathetic nerve density. Arterial blood pressure was reduced in propranolol groups during hypoxia. Propranolol exaggerated the fall in blood pressure in most (6/7) CIH animals during hypoxia, suggestive of reduced sympathetic tone. These findings therefore identify new roles for β-adrenergic stimulation in evoking CB hyperactivity, sympathetic vascular hyperinnervation and altered blood pressure control in response to CIH.
Emotion and liking: how director emotional expression and knowledge of (dis)liking may impact adults’ ability to follow the instructions of an ignorant speaker
Authors: Monk Rebecca L. , Colbert Lauren , Darker Gemma , Cowling Jade , Jones Bethany , Qureshi Adam W. 
Published: November 2020

Abstract
Background
Theory of mind (ToM), the ability to understand that others have different knowledge and beliefs to ourselves, has been the subject of extensive research which suggests that we are not always efficient at taking another’s perspective, known as visual perspective taking (VPT). This has been studied extensively and a growing literature has explored the individual-level factors that may affect perspective taking (e.g. empathy and group membership). However, while emotion and (dis)liking are key aspects within everyday social interaction, research has not hitherto explored how these factors may impact ToM.

Method
A total of 164 participants took part in a modified director task (31 males (19%), M age = 20.65, SD age = 5.34), exploring how correct object selection may be impacted by another’s emotion (director facial emotion; neutral × happy × sad) and knowledge of their (dis)likes (i.e. director likes specific objects).

Result
When the director liked the target object or disliked the competitor object, accuracy rates were increased relative to when he disliked the target object or liked the competitor object. When the emotion shown by the director was incongruent with their stated (dis)liking of an object (e.g. happy when he disliked an object), accuracy rates were also increased. None of these effects were significant in the analysis of response time. These findings suggest that knowledge of liking may impact ToM use, as can emotional incongruency, perhaps by increasing the saliency of perspective differences between participant and director.

Conclusion
As well as contributing further to our understanding of real-life social interactions, these findings may have implications for ToM research, where it appears that more consideration of the target/director’s characteristics may be prudent.
The positive effect of spermidine in older adults suffering from dementia
Authors: Pekar Thomas , Bruckner Katharina , Pauschenwein-Frantsich Susanne , Gschaider Anna , Oppliger Martina , Willesberger Julia , Ungersbäck Petra , Wendzel Aribert , Kremer Alexandra , Flak Walter , Wantke Felix , Jarisch Reinhart 
Published: November 2020

SummaryThe worldwide prevalence of dementia is estimated at 35.6 million and will rise to 115 million by 2050. There is therefore an urgent need for well-founded dementia diagnostics and well-researched therapeutic options. Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. They also confirmed that nutritional intervention with the natural polyamine spermidine can prevent memory loss in aging model organisms. This multicentric double-blind preliminary study focused on the effect of oral spermidine supplementation on older adults’ cognitive performance. Memory tests were carried out on 85 subjects aged between 60 and 96 years in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration and measurement of metabolic parameters. The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage. The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) in phonematic fluidity. By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.
Modelling resilient collaborative multi-agent systems
Authors: Vistbakka Inna , Troubitsyna Elena 
Published: November 2020

AbstractMulti-agent systems constitute a wide class of decentralised systems. Their functions are usually carried out by collaborative activities of agents. To ensure resilience of multi-agent systems, we should endow them with a capability to dynamically reconfigure. Usually, as a result of reconfiguration, the existing relationships between agents are changed and new collaborations are established. This is a complex and error-prone process, which can be facilitated by the use of formal reasoning and automated verification. In this paper, we propose a generic resilience-explicit formalisation of the main concepts of multi-agent systems. Based on it, we introduce corresponding specification and refinement patterns in Event-B. Our patterns facilitate modelling behaviour of resilient multi-agent systems in a rigorous systematic way and verification of their properties. We demonstrate the application of the proposed approach by a case study—a smart warehouse system.
Bridging the gap between child mental health need and professional service utilisation: Examining the influence of mothers’ parental attributions on professional help-seeking intentions
Authors: Sawrikar Vilas , Diaz Antonio Mendoza , Tully Lucy , Hawes David J. , Moul Caroline , Dadds Mark R. 
Published: November 2020

AbstractThere is a significant gap between the need for child mental health services and use of these services by families. Parental attributions may play a role in this. This study examined whether mothers’ attributions about their child’s problems influence professional help-seeking intentions in a general sample of community mothers. Secondary analysis re-examined this hypothesis in a subgroup of mothers of children with clinically elevated mental health symptoms. Cross-sectional survey data were collected from mothers (N = 184) of children aged between 2 and 12 years recruited from the community. Mothers completed self-report questionnaires measuring parental attributions: child-responsible attributions and parental self-efficacy; professional help-seeking intentions; and psychosocial covariates: child mental health, mothers’ anxiety and depression, child age, gender, marital status, education, and professional help-seeking experience. Hierarchical regression modelling indicated that parental attributions explained professional help-seeking intentions after controlling for covariates in both the general sample (ΔF = 6.07; p = .003) and subgroup analysis (ΔF = 10.22, p = .000). Professional help-seeking intentions were positively associated with child-responsible attributions (β = .19, p = .002) but not parental self-efficacy (β =  – .01, p = .865) in the general sample, while positively associated with child-responsible attributions (β = .20, p = .009) and negatively associated with parental self-efficacy (β =  – .16, p = .034) in the subgroup analysis. Findings were independent of the presence of clinically elevated symptoms, problem type, and severity. Overall, the findings support models suggesting that parental attributions have a role in professional help-seeking for child mental health problems.
Morpho-functional effects of different universal dental adhesives on human gingival fibroblasts: an in vitro study
Authors: Pagano Stefano , Lombardo Guido , Costanzi Egidia , Balloni Stefania , Bruscoli Stefano , Flamini Sara , Coniglio Maddalena , Valenti Chiara , Cianetti Stefano , Marinucci Lorella 
Published: November 2020

AbstractTo analyze the effects of four universal adhesives (Optibond Solo Plus—OB, Universal Bond—UB, Prime&Bond Active—PBA, FuturaBond M + —FB) on human gingival fibroblasts in terms of cytotoxicity, morphology and function. After in vitro exposure for up to 48 h, fibroblast viability was determined by the MTT assay determined, morphology by phase-contrast microscopy and migration by the scratch wound assay. Expression levels of IL1β, IL6, IL8, IL10, TNFα and VEGF genes were assessed by RT-PCR and their protein production by Western blot analysis. Apoptosis and cell cycle were analyzed by flow cytometry. OB and UB induced early morphological changes on fibroblasts (3 h) with extended cell death at 24 h/48 h. Gene expression of collagen type I and fibronectin increased fivefold compared with controls, elastin disappeared and elastase increased threefold, indicating gingival tissue tended to become fibrotic. Only UB and OB increased gene expression of inflammatory markers: IL1β at 3 and 48 h (up to about three times), IL6 and IL8 at 3 h (up to almost four times) which corresponded to the increase of the activated form NF-kB. All adhesives showed an effect on the functionality of fibroblasts with cytotoxic effect time and concentration dependent. Among all the OB and UB adhesives, they showed the greatest cell damage. The in-depth analysis of the effects of universal adhesives and possible functional effects represents an important information for the clinician towards choosing the most suitable adhesive system.
Supercooling capacity and cold tolerance of the South American tomato pinworm, Tuta absoluta, a newly invaded pest in China
Authors: Li Xiao-wei , Li Dong , Zhang Zhi-jun , Huang Jun , Zhang Jin-ming , Hafeez Muhammad , Wang Li-kun , Guo Wen-chao , Lu Yao-bin 
Published: November 2020

AbstractTuta absoluta is a devastating invasive pest worldwide, causing severe damage to the global tomato industry. It has been recorded recently in the northwestern border areas of China, posing a significant threat to tomato production. It was presumed that the region's winter-related low temperatures would avert the alien species from successfully overwintering. In this study, the supercooling capacity and low-temperature tolerance of this pest were examined under laboratory conditions and its overwintering potential in Xinjiang was estimated. The results showed that the lowest supercooling point was recorded in the adult stage (− 19.47 °C), while the highest (− 18.11 °C) was recorded in the pupal stage. The supercooling points of pupae and adults were not influenced by gender. The Ltemp50 and Ltemp90 of female and male adults were the lowest when exposed to cold for 2 h. However, when the duration of exposure extended from 4 to 10 h, the Ltemp50 and Ltemp90 of female and male pupae were the lowest. Comparison of the lowest Ltemp50 and Ltemp90 with temperatures in January indicated that T. absoluta might not be able to overwinter in most of the northern and central regions of Xinjiang. However, in the southern regions, the extremely low temperature was higher than the Ltemp90, suggesting that T. absoluta has a higher overwintering potential in these regions. These results form a basis for predicting the dispersal potential and possible geographic range of this pest in Xinjiang. In addition, our findings provide guidance for the control of this pest by reducing overwintering shelters.
Does left ventricular function predict cardiac outcome in Anderson–Fabry disease?
Authors: Spinelli Letizia , Giugliano Giuseppe , Pisani Antonio , Imbriaco Massimo , Riccio Eleonora , Russo Camilla , Cuocolo Alberto , Trimarco Bruno , Esposito Giovanni 
Published: November 2020

AbstractIn Anderson–Fabry disease (AFD) the impact of left ventricular (LV) function on cardiac outcome is unknown. Noninvasive LV pressure–strain loop analysis is a new echocardiographic method to estimate myocardial work (MW). We aimed to evaluate whether LV function was associated with outcome and whether MW had a prognostic value in AFD. Ninety-six AFD patients (41.8 ± 14.7 years, 43.7% males) with normal LV ejection fraction were retrospectively evaluated. Inclusion criteria were sinus rhythm and ≥ 2-year follow-up. Standard echocardiography measurements, myocardial mechano-energetic efficiency (MEE) index, global longitudinal strain (GLS) and MW were evaluated. Adverse cardiac events were defined as composite of cardiac death, malignant ventricular tachycardia, atrial fibrillation and severe heart failure development. During a median follow-up of 63 months (interquartile range 37–85), 14 events occurred. Patient age, cardiac biomarkers, LV mass index, left atrium volume, E/Ea ratio, LV ejection fraction, MEE index, GLS and all MW indices were significantly related to adverse outcome at univariate analysis. After adjustment for clinical and echocardiographic parameters, which were significant at univariate analysis, GLS and MW resulted independent predictors of adverse events (p < 0.01). By ROC curve analysis, constructive MW ≤ 1513 mmHg% showed the highest sensitivity and specificity in predicting adverse outcome (92.9% and 86.6%, respectively). MW did not improve the predictive value of a model including clinical data, LV diastolic function and GLS. LV function impairment (both systolic and diastolic) is associated with adverse events in AFD. MW does not provide additive information over clinical features and systolic and diastolic function.
The future of value in digitalised higher education: why data privacy should not be our biggest concern
Authors: Komljenovic Janja 
Published: November 2020

AbstractUniversities around the world are increasingly digitalising all of their operations, with the current COVID-19 pandemic speeding up otherwise steady developments. This article focuses on the political economy of higher education (HE) digitalisation and suggests a new research programme. I foreground three principal arguments, which are empirically, theoretically, and politically crucial for HE scholars. First, most literature is examining the impacts of digitalisation on the HE sector and its subjects alone. I argue that current changes in digitalising HE cannot be studied in isolation from broader changes in the global economy. Specifically, HE digitalisation is embedded in the expansion of the digital economy, which is marked by new forms of value extraction and rentiership. Second, the emerging research on the intersection of marketisation and digitalisation in HE seems to follow the theories of marketisation qua production and commodification. I argue that we need theories with better explanatory power in analysing the current digitalisation dynamics. I propose to move from commodification to assetisation, and from prices to rents. Finally, universities are digitalising in the time when the practice is superseding policy, and there is no regulation beyond the question of data privacy. However, digital data property is already a reality, governed by ‘terms of use’, and protected by the intellectual property rights regime. The current pandemic has led to ‘emergency pedagogy’, which has intensified overall digitalisation in the sector and is bypassing concerns of data value redistribution. I argue that we urgently need public scrutiny and political action to address issues of value extraction and redistribution in HE.
A Steak for Supper if the Cow Did Not Suffer: Understanding the Mechanisms Behind People’s Intention to Purchase Animal Welfare-Friendly (AWF) Meat Products
Authors: Beldad Ardion , Hegner Sabrina 
Published: November 2020

AbstractPeople have become increasingly conscious of the moral implications of their meat product consumption. The view that farm animals deserve moral considerations has generated widespread public attention to those animals’ welfare. Meat products from ethically raised animals are distinguished from non-welfare products using animal welfare-friendly (AWF) labels, such as the Better Life Trademark in the Netherlands. AWF meat products have become popular in the Netherlands, as evidenced by a substantial growth in product sales. To address the question concerning the factors influencing people’s intention to purchase AWF meat products and the extent to which those factors relate to one another, an online survey was implemented with 233 consumers from the Netherlands. Structural equation modeling results confirm the complexity of the mechanism behind people’s willingness to buy AWF meat products. Two factors strongly predict purchase intention—attitude and moral obligation. Furthermore, the effects of predictors such as knowledge of and trust in AWF labels on purchase intention are not direct but go through attitude and moral obligation.
The light/dark cycle of microalgae in a thin-layer photobioreactor
Authors: Chiarini Alessandro , Quadrio Maurizio 
Published: November 2020

AbstractA numerical study of the motion of algal cells in a representative thin-layer-cascade (TLC) photobioreactor is presented. The goal is to determine the time scale associated with the light/dark (L/D) cycle seen by the cells during their turbulent motion in the liquid culture. Owing to the limited reliability of the available numerical results which deal with time-averaged quantities and thus lack time-resolved information, the present study is based upon the Direct Numerical Simulation of the Navier-Stokes equations, a reliable but consequently expensive numerical approach which does not incur in turbulence modelling errors. Indeed, the simulation is successfully validated in terms of averaged velocity with experimental data. The availability of full temporal information allows algae cells to be followed in time along their trajectories. A large number (up to a million) of tracers is placed in the flow to mimic the algae cell. Their trajectories are statistically studied and linked to the turbulent mixing. Results indicate that, in a typical TLC reactor designed to mimic an experimental setup, cells undergo an L/D cycle with a time scale in the range 0.1–2 s. Such time scale, albeit much longer than the typical time scale of the photosynthesis, significantly benefits the productivity of the algae compared to a steady illumination.
Synthesis, characterisation and thermal behaviour of Cu-based nano-multilayer
Authors: Czagány M. , Varanasi D. , Sycheva A. , Janovszky D. , Koncz-Horváth D. , Kristaly F. , Baumli P. , Kaptay G. 
Published: November 2020

AbstractCu/AlN–Al2O3 nano-multilayer (NML) was deposited by magnetron sputtering method on 42CrMo4 steel samples, starting with a 15 nm AlN–Al2O3 layer and followed by 200 alternating layers of 5 nm thick Cu and 5 nm thick AlN–Al2O3 layers. The microstructure and thermal behaviour of the as-deposited and heat-treated multilayer was studied. Starting from about 400 °C, extensive coarsening of Cu nanocrystallites and the migration of Cu within the multilayer were observed via solid-state diffusion. Part of the initial Cu even formed micron-sized reservoirs within the NML. Due to increased temperature and to the different heat expansion coefficients of Cu and the AlN–Al2O3, the latter cracked and Cu appeared on the top surface of the NML at around 250 °C. Below 900 °C, the transport of Cu to the top surface of the NML probably took place as a solid-state flow, leading to faceted copper micro-crystals. However, above 900 °C, the Cu micro-crystals found on the top of the NML have rounded shape, so they were probably formed by pre-melting of nano-layered Cu due to its high specific surface area in the NML. Even if the Cu crystals appear on the top surface of the NML via solid-state flow without pre-melting, the Cu crystals on the top surface of the NML can be potentially used in joining applications at and above 250 °C.
Parental time restrictions and the cost of children: insights from a survey among mothers
Authors: Borah Melanie , Knabe Andreas , Pahlke Kevin 
Published: November 2020

AbstractAn important aspect when analyzing economic inequality between households with children is time. At given monetary incomes, the material well-being of families may be very different depending on how much time parents have at their disposal. In this paper, we provide estimates of the subjectively perceived cost of children depending on the extent of parental time restrictions. Building on a study by Koulovatianos, Schröder and Schmidt (J. Bus. Econ. Stat. 27:42–51, 2009) that introduces a novel way of using subjective income evaluation data for such estimations, we conduct a refined version of the underlying survey, focusing on young women with children in Germany. Our study confirms that the perceived monetary cost of children is substantial and increases with parental nonmarket time restrictions. The experienced loss in material living standards associated with supplying time to the labor market is sizeable for families with children.
Past, ongoing, and future debate on the interplay between internationalization and digitalization
Authors: Bergamaschi Mara , Bettinelli Cristina , Lissana Elena , Picone Pasquale Massimo 
Published: November 2020

AbstractThe interplay between internationalization and digitalization (IDI) is a relatively young research domain that is finding its way into numerous academic journals, which motivates us to systematically portray the proceedings and evolutions of this interplay over time, analyze its methodological and theoretical background and, more importantly, provide insights to guide future research on these phenomena. Combining qualitative and quantitative approaches, we analyze 68 peer-reviewed international business and management papers to explore the structure of knowledge production and identify the emerging trends. Our research reveals four key stages of the debate: (a) how IDI influencesinterorganizational aspects (1996–2004), (b) how digitalization influences the balance between perceived risk and returns in internationalization (2005–2009), (c) how digital advances and available internationalization channel alternatives influence IDI (2010–2014), and (d) how IDI influencesintraorganizational aspects (2015–2019). Moreover, our analysis reveals heterogeneity across theoretical perspectives, methods, and research themes over the years. Finally, we identify theoretical and methodological challenges related to IDI research.