bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Papillary Fibroelastoma Presented as Angina: A Case Report
Authors: Kang Zhefeng , Shi Jun , Guo Yingqiang , Wang Mian 
Published: June 2020

Abstract
Background: Cardiac papillary fibroelastoma is a rare, benign primary cardiac tumor, which always remains asymptomatic. Severe complications also had been reported in many cases. And the only effective therapy is surgical excision.Case presentation: Here we report a case of cardiac papillary fibroelastoma with the beginning symptom of chest pain and first diagnosis of non–ST-segment elevation myocardial infarction (NSTEMI). The patient finally underwent tumor excision surgery and recovered well.Conclusion: For patients with symptomatic cardiac papillary fibroelastoma we provide a series of comprehensive data before, during and after operation. This might be helpful for the further diagnosis and treatment of the tumor.
Maternal and community factors associated with postnatal care checkups in Ethiopia: A multi-level analysis
Authors: Tadele Afework , Getinet Masrie 
Published: June 2020

Abstract
Background

Maternal mortality remained a public health issue, especially in developing countries. Although the first two days after birth was a critical time in which the highest maternal death recorded, it was the most neglected period of maternal health services. Therefore, this study aims to determine the maternal and community-level factors of postnatal check-ups in Ethiopia

Methods

Demographic and Health Survey (DHS) in 2016 was utilized. A total of 3,948 women aged 15-49 giving birth in the two years before the survey were included. The response variables were post-natal check-ups in the first two days after birth, dichotomized into no check-ups in the first two days and check-ups within two days after giving birth. The explanatory variables were individual maternal characteristics such as education, household wealth, perceived distance to a health facility to get medical help, employment status, antenatal care (ANC), delivery by cesarean section, birth order and place of delivery, and selected community characteristics such as community literacy, community socioeconomic status, community ANC coverage, community perception of distance to a health facility, and regional states. A multi-level mixed-effects logistic regression model was employed.

Result

Only 17% of the women had a postnatal check-up within 2 days of giving birth in Ethiopia. Institutional delivery AOR 2.14 [95% C.I 1.70, 2.0] and giving birth by cesarean section AOR 1.66 [95% CI 1.10, 2.50] were found to be maternal factors, whereas administrative regions(Oromia 69%, Somali 56%, Benishangul 55%, SNNPR 43%, Gambela 66%, Afar 50% and Dire Dawa 55% which less likely to utilize postnatal care utilization as compared to Addis Ababa city administrative area), Higher community-level wealth AOR 1.44 [95% C.I 1.08, 1.2], ANC coverage AOR 1.52 [95% C.I 1.19, 1.96] and perceived distance of the health facility as a big problem AOR 0.78[95% C.I 0.60, 0.99] were the community factors associated with postnatal check-ups in Ethiopia.

Conclusion

Both maternal factors and community factors are found to be a significant association with postnatal care services utilization, however, based on the ICC maternal factors prevail the community-level factors. Increasing access to postnatal care services to the remote areas of Ethiopia was recommended.
Infectious endocarditis: Improving Diagnostic Performance in Native and Prosthetic Valve Infection with 18F-FDG PET/CT
Authors: Marinho Ana Vera , Almeida José Paulo , Soeiro Paula , Silva Rodolfo , Gonçalves Francisco , Costa Gracinda , Gonçalves Lino , Ferreira M.J 
Published: June 2020

Abstract
BackgroundThe diagnosis of infective endocarditis (IE) remains a clinical challenge. Diagnostic accuracy of the modified Duke criteria is suboptimal for native valve endocarditis (NVE) and even worse in the presence of prosthetic material-related infection (PVE). We aim to evaluate the diagnostic performance of 18F-FDG PET in patients with suspected IE referred to perform PET/CT.Methods: Consecutive patients with suspected IE, referred to perform PET/CT between May 2016 and June 2019 were included. Diagnostic performance of modified Duke criteria (mDC) and PET/ CT for IE for NVE and PVE was determined.Results: In total, 82 patients (mean age of 61 ± 19 years, 62% of male gender) were enrolled. There were 67 18F-FDG PET/CT concordant results with final diagnosis, corresponding to a 96% of agreement, k=0.91(p=0.04). A SUVmax cutoff value of ≥3.1 identified positive cases with 88.9% sensitivity and 70.0% specificity. In patients with NVE, the addition of PET/CT to the mDC resulted in a reduction of the number of possible IE cases (from 58% to 4.3%). In patients with PVE/intracardiac devices, PET/CT allowed reclassification of 67.4% of possible cases to 4.2%. An alternative diagnosis was provided in 55.6% of the negative IE cases.Conclusions: 18F-FDG PET/CT proved to be a useful diagnostic tool in patients with both suspected NVE and PVE with good sensitivity and specificity, resulting in a significant decrease of the number of possible endocarditis. Furthermore, it allowed the identification of the cause of clinical scenario in more than 50% of patients in which the diagnosis was excluded.
Microstructure and Properties of Cped Thermal Protective Coating Modified by Platinum Particles on Al-SI Alloy
Authors: Wang Ping , Chen Xiaomin , Zhang Chunqing , Jiao Di , Jiao Shangyi , Yao Min 
Published: June 2020

Abstract
The thermal protection layer of cathode plasmaelectrolytic deposition on platinum particles was prepared on Al-Si alloy.The microstructure and the heat insulation performance, fracture toughness and bending strengthof the coating were investigated by SEM, XRD, the heat insulation test device and tensile testing machine. The distribution of platinum particles in the ceramic layer is uniform, which can effectively fill the micropores of plasma discharge. The ceramic layer is mainly composed ofα-Al2O3 and t-ZrO2, and there is the formation of high temperature stable phase Zr3Y4O12in the ceramic layer. With the increase of platinum particles, the heat insulation temperature, fracture toughness and bending strength gradually increase.After thermal shock, no obvious cracks were found on the surface of the coating, which indicated that the coating had good thermal shock resistance.
Effects and mechanisms of AMIGO2 in proliferation, migration and drug resistance of bladder cancer
Authors: Han Dali , Xiong Bin , Zhang Xiangxiang , Chen Chaohu , Yao Zhiqiang , Wu Hao , Cao Jinlong , Li Jianpeng , Li Pan , Wang Zhiping , Tian Jun-Qiang 
Published: June 2020

Abstract
Background Bladder cancer is the most common malignancy in urinary system, but the therapeutic targets remain elusive. This study aims to reveal the relationship between AMIGO2 and proliferation, migration, drug-resistance and tumorigenicity of bladder cancer, and explore the potential molecular mechanisms. Methods The expression of AMIGO2 in human bladder cancer tissues is measured by qRT-PCR and immunohistochemistry (IHC). Stable AMIGO2 knockdown cell lines T24 and 5637 were established by lentivirus transfection. Cell viability assay (CCK-8 assay) was used to determine cell proliferation, flow cytometry analysis was utilized to detect cell cycle, and wound healing assay was proceeded to test migration ability of bladder cancer cells. Chemosensitivity to cisplatin was measured by CCK-8 assay. Xenograft mouse model was established for investigating the effect of AMIGO2 on tumor formation in vivo. The RNA Sequencing technology was used to explore differentially expressed genes (DEGs) between knockdown group and negative control group of T24. Bioinformatics analysis upon the results of RNA-Seq was proceeded to understand underlying mechanisms. Results AMIGO2 was upregulated in bladder cancer cells and tissues. Inhibited expression of AMIGO2 suppresses cell proliferation and migration, which might be mediated by cell cycle arrest in G1 phase. AMIGO2 could reduce chemoresistance to cisplatin in bladder cancer cells. Low AMIGO2 expression inhibited tumorigenicity of T24 in nude mice. 917 DEGs were identified by RNA-Sequencing technology and bioinformatics analysis. The DEGs were mainly enriched in cell-cell adhesion, ATP-binding cassette transporters (ABC transporters), PPAR signaling pathway and some other pathways. Among ten hub genes, four of them might be associated with the prognosis of bladder cancer patients. Conclusion AMIGO2 is overexpressed in bladder cancer cells and tissues and serves as an oncogene in bladder cancer. It also reduces chemoresistance to cisplatin. The process might be regulated by particular pathways including ABC transporters and PPAR signaling pathway. Four hub genes might be associated with prognosis of bladder cancer patients.
Co-existence of Hypertension and Pre-existing Cardiovascular Disease and Mortality in Patients on Continuous Ambulatory Peritoneal Dialysis
Authors: Wang Xiaoyang , Zhan Xiaojiang , Zhou Qing , Feng Xiaoran , Peng FenFen , Wang Niansong , Wen Yueqiang , Wu Xianfeng 
Published: June 2020

Abstract
Background

Little is known about whether co-existence of hypertension (HTN) and pre-existing cardiovascular disease (CVD) has a more harmful effect on mortality compared with either comorbidity alone in patients on continuous ambulatory peritoneal dialysis (CAPD).
Methods

We conducted a retrospective study of 3073 incident Chinese patients on CAPD from five dialysis centers between January 1, 2005 and December 31, 2018 in a real-world setting. The primary and secondary outcomes were all-cause and CVD mortality. The association between interesting comorbidities and mortality was analyzed using Cox regression models and the Fine and Gray competing risk models.
Results

Over a median of 33.7 months of follow-up, 581 (18.6%) patients died, with 286 (9.3%) CVD mortality. The incidence of all-cause mortality was 32.2, 56.1, 74.4, and 131.0/1000 patient-years, and the incidence of CVD mortality was 15.0, 28.2, 34.7, and 69.6/1000 patient-years in the control group (those without either hypertension or CVD), HTN group, CVD group, and HTN plus CVD group respectively. After adjusting for the confounding factors, HTN plus CVD, CVD, and HTN groups had a higher risk of all-cause mortality (HR 3.98, 95% CI 3.07 to 5.17; HR 2.18, 95% CI 1.27 to 3.74; and HR 1.83, 95% CI 1.47 to 2.28) and CVD mortality (HR 4.68, 95% CI 3.27 to 6.69; HR 2.11, 95% CI 0.96 to 4.63; and HR 1.87, 95% CI 1.37 to 2.54), respectively, compared to the control group. Similar findings were observed using the Fine and Gray competing risk models. There was no significant interaction between HTN and CVD on all-cause and CVD mortality (β = 0.010, P = 0.973; β = 0.058, P = 0.892) in the study population.
Conclusions

Among CAPD patients, co-existence of HTN and pre-existing CVD at the start of CAPD had a more harmful effect on mortality compared to either HTN or pre-existing CVD alone, and pre-existing CVD may have also a more harmful effect on mortality than HTN.
Water diversion and allocation for typical confined polder river-net in Taihu Basin
Authors: Xiang Long , Ma Mengting , Jiao Lihong , Liao Zhengmin 
Published: June 2020

AbstractHydraulic restoration in a confined polder river-net is a new issue under the concept of the Interconnected River System Network (IRSN) proposed by the Ministry of Water Resources (MWR) in China. This paper studies the typical hydrographic connection in the polder, and analyses the current situation of the hydrographic river-net in the typical area of Subaiwei in Changshu City by setting up a one-dimensional unsteady hydrodynamic model. The best water diversion-allocation schemes in the confined polder river-net are simulated and optimized in various scheduling rules. In order to recover the ability of hydro-connection and stream function, the effects of different scheduling rules and the duration time of water diversion under the ability of pump stations around polder boundary are compared. The results show that the optimized injects can enhance the total flow velocity and the exchange rate is more than 20% on average in various streams. This study is critical for the sustainable utilization of limited clean water in a confined river-net polder, and for quantifying the water ecological recharge for hydrodynamic connection.
Expression and Purification of the VpDef Defensin in Escherichia coli using the Small Metal-Binding Proteins CusF3H+ and SmbP
Authors: Montfort-Gardeazabal Jorge M. , Claudio Pilar C. Morales-San , Casillas-Vega Nestor G. , Zarate Xristo 
Published: June 2020

Background:
The heterologous production of antimicrobial peptides in bacterial models
can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to
increase the expression and solubility of these types of proteins with varying degrees of success.

Objectives:
Here, we demonstrate the use of the small metal-binding proteins CusF3H+ (9.9kDa)
and SmbP (9.9kDa) as fusion partners for the soluble expression of the bioactive antimicrobial peptide
VpDef(6.9 kDa) in Escherichia coli.

Methods:
The recombinant VpDef (rVpDef) peptide was expressed as a translational fusion with
CusF3H+ and SmbP in Escherichia coli SHuffle under different small-scale culture conditions.
The best conditions were applied to 1-liter cultures, with subsequent purification of the recombinant
protein through IMAC chromatography. The recombinant protein was digested using enterokinase
to liberate the peptide from the fusion protein, and a second IMAC chromatography step removed
the fusion protein. The purified peptide was tested against two Gram-positive and two
Gram-negative bacteria.

Results:
The use either of CusF3H+ or of SmbP results in recombinant proteins that are found in
the soluble fraction of the bacterial lysate; these recombinant proteins are easily purified through
IMAC chromatography, and rVpDef is readily separated following enterokinase treatment. The purified
rVpDef peptide exhibits antimicrobial properties against both Gram-positive and Gram-negative.

Conclusion:
Use of the fusion proteins CusF3H+ and SmbP results in production of a soluble recombinant
protein containing the antimicrobial peptide rVpDef that is correctly folded and that retains
its antimicrobial properties once purified.
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy
Authors: Khandker Shahad Saif , Shakil Md. Salman , Hossen Md. Sakib 
Published: June 2020

Background:
Breast cancer is a heterogeneous disease typically prevalent among women and is the
second-largest cause of death worldwide. Early diagnosis is the key to minimize the cancer-induced complication,
however, the conventional diagnostic strategies have been sluggish, complex, and, to some extent, non-specific.
Therapeutic tools are not so convenient and side effects of current therapies offer the development of novel
theranostic tool to combat this deadly disease.

Objective:
This article aims to summarize the advances in the diagnosis and treatment of breast cancer with gold
nanoparticles (GNP or AuNP).

Methods:
A systematic search was conducted in the three popular electronic online databases including PubMed,
Google Scholar, and Web of Science, regarding GNP as breast cancer theranostics.

Results:
Published literature demonstrated that GNPs tuned with photosensitive moieties, nanomaterials, drugs,
peptides, nucleotide, peptides, antibodies, aptamer, and other biomolecules improve the conventional diagnostic and
therapeutic strategies of breast cancer management with minimum cytotoxic effect. GNP derived diagnosis system
assures reproducibility, reliability, and accuracy cost-effectively. Additionally, surface-modified GNP displayed
theranostic potential even in the metastatic stage of breast cancer.

Conclusion:
Divergent strategies have shown the theranostic potential of surface tuned GNPs against breast cancer
even in the metastatic stage with minimum cytotoxic effects both in vitro and in vivo.
Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies
Authors: Hadda Taibi B. , Deniz Fatma S.S. , Orhan Ilkay E. , Zgou Hsaine , Rauf Abdur , Mabkhot Yahia N. , Bennani Brahim , Emam Dalia R. , Kheder Nabila A. , Asayari Abdulrhman , Muhsinah Abdullatif B. , Maalik Aneela 
Published: June 2020

Background:
One of the best methods to treat Alzheimer disease (AD) is through the effective
use of cholinesterase inhibitors as vital drugs due to the identification of acetylcholine deficit in the
AD patients.

Objective:
The present study aims the investigation of spiro heterocyclic compounds as potential AD
agents supported by their metal chelation capacity, POM analyses and DFT studies, respectively.

Methods:
The cholinesterase inhibition and metal chelation ability were performed on ELISA microtiter
assay. Whereas, the B3LYP method with 6-31+G(d,p) basis set was implemented to study HOMOLUMO
energy calculations. The pharmacokinetic properties of the synthesized molecules were studied
through Petra, Osiris and Molinspiration (POM).

Results:
The six spiro (1-6) skeletons were tested for their inhibitory potential and metal-chelation capacity.
Our findings revealed that the tested spiro skeletons exerted none or lower than 50% inhibition
against both cholinesterases, while compound 4 proved to be the most active molecule with
57.21±0.89% of inhibition toward BChE. The spiro molecule 3 exhibited the highest metal-chelation
capacity (9.12±5.26%). Molecular docking model for the most active molecule exhibited promising
bindings with AChE and BChE’s active site pertained to hydrophobic hydrogen bonds and positive ionizable
interactions. The POM analyses gave the information about the flexibility at the site of coordination
of spiro compounds (1-6).

Conclusion:
The screening of spirocompounds (1-6) against cholinesterases revealed that some of them
show considerable potential to inhibit AChE and BChE. Herein, we propose that the spiro molecules
after further derivatization could serve interesting AD inhibitor drugs.
Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study
Authors: Krithika Uma , Prabitha Prabhakaran , Mandal Subhankar P. , Yuvaraj Sivamani , Priya Durai , Wadhwani Ashish D. , Prashantha Kumar Bommenahally Ravanappa 
Published: June 2020

Background:
A series of novel 5-substituted benzylidene rhodanine derivatives using four
different amines were designed based on our previously developed CoMSIA (Comparative molecular
similarity indices analysis) model for the anticancer activity.

Methods:
The designed rhodanines were synthesized via dithiocarbamate formation, cyclization and
Knoevenagel condensation. The structures of the synthesized compounds were confirmed and analyzed
by spectral studies.

Results:
The synthesized rhodanines were investigated for in vitro anticancer activities and the analogs
have displayed mild to significant cytotoxicity against MCF-7 breast cancer cells. The compounds with
benzyloxy substitution at the fifth position of rhodanine ring (Compounds 20, 33 and 38) system showed
significant cytotoxic activity against MCF-7 cells. CoMSIA, a three-dimensional quantitative structureactivity
relationship (3D-QSAR) technique was accomplished to elucidate structure-activity relationships.

Conclusions:
Based on the information derived from CoMSIA contour plots, some key features for increasing
the activity of compounds have been identified and used to design new anti-cancer agents. The
present developed CoMSIA model displayed good external predictability, r2pred of 0.841 and good statistical
robustness.
Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats
Authors: El-Ouady Fadwa , Eddouks Mohamed 
Published: June 2020

Aims:
The study was conducted to assess the antidiabetic and antihyperlipidemic effects of
Lippia citriodora.

Background:
Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.

Objective:
The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.

Methods:
Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of
Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also
evaluated. The in vitro antioxidant activity of LCLAE was also assessed.

Results:
LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated
the liver structure and exhibited antioxidant activity.

Conclusion:
In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects
of LCLAE in rats.
Мандельштам-бриллюэновское рассеяние света в растворах бычьего сывороточного альбумина при различных концентрациях в окрестности тепловой денатурации
Authors: Дмитриев А.В. , Федосеев А.И. , Лушников С.Г. 
Published: June 2020

Results of Brillouin light scattering studies of phase transformations in bovine serum albumin (BSA) in the temperature range 300 – 380 K in the protein solution with concentration 50 and 5 mg/ml are presented. In the analysis of the results, the sequence of phase transformations in a concentrated BSA solution (100 mg/ml) was used as a reference.	It was shown that sequence of BSA phase transformations modified with a decrease in concentration. For instance, in the vicinity of denaturation, the region with fibril-like aggregate disappears, and the properties of the gel-like high temperature phase change.
Proyectos y obras para el uso de los terrenos desecados del antiguo lago de Texcoco, 1912-1998
Authors: Soto Coloballes Natalia Verónica 
Published: June 2020

<p>El presente trabajo examina las ideas acerca del posible uso de la tierra descubierta debido a la desecación del lago de Texcoco, producto del Desagüe del Valle de México. El texto explica la variedad de ideas propuestas por ingenieros y otros expertos, muchos de los cuales imaginaron un espacio de múltiples usos, con fines agrícolas, silvícolas, recreativos y ecológicos. La aportación de esta investigación consiste en mostrar cómo y por qué esos planes e ideas cambiaron a lo largo del siglo XX. Los resultados muestran que la transformación de su aspecto y naturaleza ha sido un anhelo constante, limitado por las especiales condiciones del subsuelo. Para la realización de esta investigación se consultó un gran número de fuentes escritas y se acudió al Archivo Histórico y Biblioteca Central del Agua y al Museo Archivo de la Fotografía.</p>