bluuebunny/crossref_metadata_2025_split huggingface dataset:
From tunnel NMO to layered polymorphs oxides for sodium ion batteries
Authors: Nuti Michele , Spada Daniele , Quinzeni Irene , Capelli Stefano , Albini Benedetta , Galinetto Pietro , Bini Marcella 
Published: October 2020

AbstractThe search for highly performing cathode materials for sodium batteries is a fascinating topic. Unfortunately, Na0.44MnO2 (NMO), the well-known cathode material with good electrochemical performances, suffers from structural degradation due to reduction of Mn4+ to the Jahn–Teller Mn3+ ion, limiting the long-term cyclability. The cation substitution can be a useful way to mitigate the problem, thanks to the possible stabilization of mixtures of different polymorphs. In this paper, NMO was first substituted with Fe ions, obtaining Na0.44Mn0.5Fe0.5O2, with layered structure, then Al, Si and Cu (10% atom) were substituted on both Mn and Fe ions. Mixtures of P3 type phases, in different amount depending on dopant, were obtained and quantified by Rietveld refinements, and relationships between chemical composition, polymorph type and morphology were proposed. Cyclic voltammetry showed broad peaks, due to the complex structural transitions consequent to the intercalation/deintercalation of sodium. Charge discharge cycles disclosed the superior performances of Cu doped sample, which also benefits from improved air stability, a well-known issue of layered compounds. Discharge capacity values of about 63 mAh/g were detected at 1C, and after 50 cycles at C/2, capacities of about 80 mAh/g are obtained, with a capacity retention of 86%.
Medicare Accountable Care Organizations and the Adoption of New Surgical Technology
Authors: Modi Parth K. , Kaufman Samuel R. , Caram Megan EV. , Ryan Andrew M. , Shahinian Vahakn B. , Hollenbeck Brent K. 
Published: October 2020

BACKGROUND:
Dissemination of new surgical technology is a major contributor to healthcare spending growth. Accountable care organization (ACO) policy aims to control spending while maintaining quality. As a result, ACOs provide incentive for hospitals to selectively adopt newer procedures with high value.

STUDY DESIGN:
We conducted a retrospective cohort study using a 20% sample of national Medicare claims from 2010 to 2015. We identified hospitals that performed 1 of 6 sets of procedures: abdominal aortic aneurysm repair, aortic valve replacement, carotid endarterectomy or stent, lung lobectomy, colectomy, and prostatectomy. We identified hospitals participating in a Medicare Shared Savings Program ACO and a set of matched non-ACO control hospitals. We used a difference-in-differences approach to compare rate of surgical treatment and use of newer surgical technology for each set of procedures in ACO and non-ACO hospitals.

RESULTS:
We included 707 ACO-hospitals and 1,770 control hospitals. ACO hospitals performed surgery for carotid stenosis at a lower rate than non-ACO hospitals. There was no difference in the rate of surgical treatment for all other procedure sets. ACO hospitals were less likely to use an endovascular approach for abdominal aortic aneurysm repair (85.2% vs 88.2%, p < 0.001) and more likely to use a minimally invasive approach for lung lobectomy (42.2% vs 34.7%, p = 0.004) than non-ACO hospitals. In difference-in-differences analysis, ACO participation was not associated with any significant difference in use of surgical care for any of the 6 procedure sets, nor with any significant difference in use of newer surgical technology.

CONCLUSIONS:
Despite ACO policy incentives to selectively adopt newer surgical technology, ACO participation was not associated with differences in rate of surgery or use of newer surgical technology for 6 major surgical procedures.
Thoughts on the Future Medical Care Pattern of Pediatrics in China Based on the Outbreak of COVID-19
Authors: Liu Hui , Wang Li 
Published: October 2020

ABSTRACTThe outbreak of pneumonia known as coronavirus disease (COVID-19) has occurred in China since December 2019 and spread rapidly across the world. Pediatric medical workers have a serious imbalance doctor–patient ratio in China; they have accumulated experience during the fight against COVID-19; however, some flaws were revealed in their current medical system. Meanwhile, these problems were also reported in other countries. Thus far, the outbreak of COVID-19 is still rampant across the world. The experience from anti-COVID-19 could be useful and teach us to provide better medical services for Chinese children and prepare for similar public emergencies in the future. Furthermore, it also provides guidance for pediatric medical staff in managing COVID-19 in other developing countries.
Changes in antimicrobial utilization during the coronavirus disease 2019 (COVID-19) pandemic after implementation of a multispecialty clinical guidance team
Authors: Staub Milner B. , Beaulieu Ronald M. , Graves John , Nelson George E. 
Published: October 2020

AbstractObjective:Evaluate changes in antimicrobial use during COVID-19 and after implementation of a multispecialty COVID-19 clinical guidance team compared to pre–COVID-19 antimicrobial use.Design:Retrospective observational study.Setting:Tertiary-care academic medical center.Participants:Internal medicine and medical intensive care unit (MICU) provider teams and hospitalized COVID-19 patients.Methods:Difference-in-differences analyses of antibiotic days of therapy per 1,000 patient days present (DOT) for internal medicine and MICU teams treating COVID-19 patients versus teams that did not were performed for 3 periods: before COVID-19, initial COVID-19 period, and after implementation of a multispecialty COVID-19 clinical guidance team which included daily, patient-specific antimicrobial stewardship recommendations. Patient characteristics associated with antibiotic DOT were evaluated using multivariable Poisson regression.Results:In the initial COVID-19 period, compared to the pre–COVID-19 period, internal medicine and MICU teams increased weekly antimicrobial use by 145.3 DOT (95% CI, 35.1–255.5) and 204.0 DOT (95% CI, −16.9 to 424.8), respectively, compared to non–COVID-19 teams. In the intervention period, internal medicine and MICU COVID-19 teams both had significant weekly decreases of 362.3 DOT (95% CI, −443.3 to −281.2) and 226.3 DOT (95% CI, −381.2 to –71.3). Of 131 patients hospitalized with COVID-19, 86 (65.6%) received antibiotics; no specific patient factors were significantly associated with an expected change in antibiotic days.Conclusions:Antimicrobial use initially increased for COVID-19 patient care teams compared to pre–COVID-19 levels but significantly decreased after implementation of a multispecialty clinical guidance team, which may be an effective strategy to reduce unnecessary antimicrobial use.
An initial examination of the psychometric properties of the Diagnostic Instrument for Social and Communication Disorders (DISCO-11) in a clinical sample of children with a diagnosis of Autism spectrum disorder
Authors: Anglim Margo , Conway Emma Victoria , Barry Myra , Kashif Muhammad , Ackermann Pauline , Moran Aoife , O’Connell Anne Sophie , Guerin Suzanne 
Published: October 2020

Introduction:The diagnostic interview for social and communication disorders (DISCO – 11; Wing 2006), is a semi-structured, interview-based instrument used in the diagnosis of children with autism spectrum disorder (ASD). This paper explores the psychometric properties of the DISCO-11 used in a specialist Paediatric clinical setting. Two key research questions were examined; (1) Does the factor structure of the DISCO-11 reflect the diagnostic and statistical manual 5th edition (DSM-5, American Psychiatric Association [APA], 2013) dyad of impairment in ASD? (2) Is there evidence of diagnostic stability over time using the DISCO?Methods:Review assessments of 65 children with ASD were carried out using standardised measures including the DISCO-11 and the autism diagnostic observation schedule.Results:The results revealed two factors resembling the DSM-5 algorithms, as used in DISCO-11, which were named as social-communication, and restricted and repetitive behaviours. The reliability, for the overall DISCO score was good (Cronbach’s alpha = 0.78). The social communication and social interaction subscale showed good reliability (Cronbach’s Alpha = 0.77) as did the restricted and repetitive patterns of behaviour, interests or activities subscale (Cronbach’s Alpha = 0.74). Acceptable internal reliability was found for the overall DISCO score and the subscales of social communication and social interaction and the restricted and repetitive patterns of behaviour, interests or activities. Test–retest showed good stability of diagnosis over time.Discussion:This study supports that the DISCO-11 shows potential as a valid and reliable instrument that can be used both for clinical and research purposes.
COMPUTABILITY OF POLISH SPACES UP TO HOMEOMORPHISM
Authors: HARRISON-TRAINOR MATTHEW , MELNIKOV ALEXANDER , MENG NG KENG 
Published: October 2020

AbstractWe study computable Polish spaces and Polish groups up to homeomorphism. We prove a natural effective analogy of Stone duality, and we also develop an effective definability technique which works up to homeomorphism. As an application, we show that there is a $\Delta ^0_2$ Polish space not homeomorphic to a computable one. We apply our techniques to build, for any computable ordinal $\alpha $, an effectively closed set not homeomorphic to any $0^{(\alpha )}$-computable Polish space; this answers a question of Nies. We also prove analogous results for compact Polish groups and locally path-connected spaces.
The Idea of Islamic Media: The Qur'an and the Decolonization of Mass Communication
Authors: Moll Yasmin 
Published: October 2020

AbstractThe emergence of Islamic television in the Arab Middle East is usually explained as part of a Saudi media empire fueled by neoliberal petro-dollars. This article, by contrast, takes seriously the role ideas played alongside changing political economies in the origins of the world’s first Islamic television channel, Iqraa. Focusing on the intellectual and institutional career of “Islamic media” (al-i’lām al-Islāmī) as a category from the late sixties onwards in Egypt, I argue that Islamic television is part of a broader decolonization struggle involving the modern discipline of mass communication. Pioneering Arab communication scholars mounted a quest for epistemic emancipation in which the question of how to mediate Islam became inextricable from the question of what made media Islamic. Drawing on historical and ethnographic research, I show how the idea of Islamic media involved a radical reconceptualization of the Qur'an as mass communication from God and of Islam as a mediatic religion. This positing of an intimate affinity between Islam and media provoked secular skepticism and religious criticism that continue to this day. I conclude by reflecting on how the intellectual history of Islamic media challenges dominant framings of epistemological decolonization as a question of interrogating oppressive universalisms in favor of liberatory pluralisms.
Commodity Production and Indigenous Institutions in Southeast Asian Long-Run Economic Development
Authors: de Zwart Pim 
Published: October 2020

AbstractThe Making of a Peripherymakes three important claims. First, commodity export production does not necessarily result in peripheralization, which is defined as economic stagnation, depressed wages and impoverishment. Second, peripheralization is instead influenced by the specific mode of production of export commodities. Third, the mode of production is crucially determined by demographic growth and patron-client relationships. This essay investigates these claims using a variety of economic and demographic data on Southeast Asia in the nineteenth and twentieth centuries. It is shown that specialization in primary commodity exports does lower long-term economic growth rates and that indigenous institutions regarding family systems and property rights play an important role in the patterns of economic development.
Modal descent
Authors: Cherubini Felix , Rijke Egbert 
Published: October 2020

AbstractAny modality in homotopy type theory gives rise to an orthogonal factorization system of which the left class is stable under pullbacks. We show that there is a second orthogonal factorization system associated with any modality, of which the left class is the class of ○-equivalences and the right class is the class of ○-étale maps. This factorization system is called the modal reflective factorization system of a modality, and we give a precise characterization of the orthogonal factorization systems that arise as the modal reflective factorization system of a modality. In the special case of the n-truncation, the modal reflective factorization system has a simple description: we show that the n-étale maps are the maps that are right orthogonal to the map
$${\rm{1}} \to {\rm{ }}{{\rm{S}}^{n + 1}}$$
. We use the ○-étale maps to prove a modal descent theorem: a map with modal fibers into ○X is the same thing as a ○-étale map into a type X. We conclude with an application to real-cohesive homotopy type theory and remark how ○-étale maps relate to the formally etale maps from algebraic geometry.
Evaluating Zr/Rb Ratio From XRF Scanning as an Indicator of Grain‐Size Variations of Glaciomarine Sediments in the Southern Ocean
Authors: Wu Li , Wilson David J. , Wang Rujian , Yin Xuebo , Chen Zhihua , Xiao Wenshen , Huang Mengxue 
Published: October 2020

AbstractThe ln(Zr/Rb) count ratio derived from X‐ray fluorescence (XRF) core scanning holds potential as a high‐resolution tracer for grain‐size variations of glaciomarine sediments, and hence current strength. To evaluate this approach, we conducted high‐resolution grain‐size measurements, together with Rb and Zr measurements by XRF core scanning and inductively coupled plasma‐mass spectrometry (ICP‐MS), on a series of sediment cores from different regions of the Southern Ocean. Downcore changes of the ln(Zr/Rb) count ratio from XRF core scanning are consistent with Zr/Rb concentration ratios derived from ICP‐MS analyses, even though Rb and Zr counts deviate significantly from concentrations due to specimen and matrix effects. The ln(Zr/Rb) count ratio displays discrepancies with the bulk mean grain‐size, but correlates well with the mean grain‐size of the sediment fractions that do not include unsorted sand delivered by ice‐rafting. These observations are supported by evidence from a grain‐size separation experiment, which indicates that Zr and Rb are concentrated in different grain‐size fractions. Consistent with its lack of sensitivity to coarse grain‐size fractions derived from ice‐rafting, the ln(Zr/Rb) ratio records similar trends to the sortable silt percent (SS%) and sortable silt mean () grain‐size. Universal gradients exist in plots of SS% versus ln(Zr/Rb), and versus ln(Zr/Rb), such that the ln(Zr/Rb) ratio provides a convenient way to estimate the magnitude of changes in SS% and . Overall, our results support the use of the ln(Zr/Rb) ratio as an indicator of bottom current strength in cases where the sediment is current‐sorted.
Dissolved Inorganic Carbon Transport in the Surface‐Mixed Layer of the Louisiana Shelf in Northern Gulf of Mexico
Authors: Anderson M. M. , Maiti K. , Xue Z. George , Ou Y. 
Published: October 2020

AbstractRivers and wetlands are a major source of terrestrial derived carbon for coastal ocean margins. This results in a net loss of terrestrial carbon into the shelf water and their subsequent transport to interior ocean basin. This study investigates the transport of dissolved inorganic carbon (DIC) in the surface‐mixed layer of Louisiana Shelf in northern Gulf of Mexico (nGOM) adjacent to the Wax Lake Delta (WLD) and Barataria Bay (BB), which represent contrasting net land gain and net land loss areas in this region. DIC samples were collected, in conjunction with short‐lived radium isotopes 224Ra (t1/2 = 3.66 days) and 223Ra (t1/2 = 11.43 days) samples during June and September 2019, to quantify shelf transport of DIC in the surface‐mixed layer during period of high and low river flow, respectively. Radium distribution implied shelf mixing rates of 140–6,759 and 63–2,724 m2 s−1 for WLD and BB regions, respectively, with more than tenfold decrease in rates between the two seasons. Net shelf transport of DIC was found to be highest for the WLD region in June, highlighting the importance of freshwater discharge in exporting DIC. An upscaling of our study for the entire Louisiana Shelf indicates that 1.54–20.19 × 109 mol C d−1 transported in June 2019 and 0.34–8.12 × 109 mol C d−1 in the form of DIC was exported across the shallow region of the shelf during high and low river flow seasons, representing an important source of DIC to the NGOM.
Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade
Authors: Li Chen , Meng Fantao , Lei Yun , Liu Jing , Liu Jing , Zhang Jingyan , Liu Fang , Liu Cuilan , Guo Ming , Lu Xin-Yun 
Published: October 2020

AbstractLeptin is an adipocyte-derived hormone with pleiotropic functions affecting appetite and mood. While leptin’s role in the regulation of appetite has been extensively studied in hypothalamic neurons, its function in the hippocampus, where it regulates mood-related behaviors, is poorly understood. Here, we show that the leptin receptor (LepRb) colocalizes with brain-derived neurotrophic factor (BDNF), a key player in the pathophysiology of major depression and the action of antidepressants, in the dentate gyrus of the hippocampus. Leptin treatment increases, whereas deficiency of leptin or leptin receptors decreases, total Bdnf mRNA levels, with distinct expression profiles of specific exons, in the hippocampus. Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of the Bdnf gene induced by leptin. This is mediated by stimulation of AKT signaling, which in turn activates histone acetyltransferase p300 (p300 HAT), leading to changes in histone H3 acetylation and methylation at specific Bdnf promoters. Furthermore, deletion of Bdnf in the dentate gyrus, or specifically in LepRb-expressing neurons, abolishes the antidepressant-like effects of leptin. These findings indicate that leptin, acting via an AKT-p300 HAT epigenetic cascade, induces exon-specific Bdnf expression, which in turn is indispensable for leptin-induced antidepressant-like effects.
Activation of mTORC1 by LSECtin in macrophages directs intestinal repair in inflammatory bowel disease
Authors: Li Qian , cheng Hanxing , Liu Yuanping , Wang Xiaowen , He Fuchu , Tang Li 
Published: October 2020

AbstractDamage to intestinal epithelial cells and the induction of cellular apoptosis are characteristics of inflammatory bowel disease. The C-type lectin receptor family member LSECtin promotes apoptotic cell clearance by macrophages and induces the production of anti-inflammatory/tissue growth factors, which direct intestinal repair in experimental colitis. However, the mechanisms by which the phagocytosis of apoptotic cells triggers the pro-repair function of macrophages remain largely undefined. Here, using immunoprecipitation in combination with mass spectrometry to identify LSECtin-interacting proteins, we found that LSECtin interacted with mTOR, exhibiting a role in activating mTORC1. Mechanistically, apoptotic cells enhance the interaction between LSECtin and mTOR, and increase the activation of mTORC1 induced by LSECtin in macrophages. Elevated mTORC1 signaling triggers macrophages to produce anti-inflammatory/tissue growth factors that contribute to the proliferation of epithelial cells and promote the reestablishment of tissue homeostasis. Collectively, our findings suggest that LSECtin-dependent apoptotic cell clearance by macrophages activates mTORC1, and thus contributes to intestinal regeneration and the remission of colitis.
Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition
Authors: Quaresma Margarida C. , Pankonien Ines , Clarke Luka A. , Sousa Luís S. , Silva Iris A. L. , Railean Violeta , Doušová Tereza , Fuxe Jonas , Amaral Margarida D. 
Published: October 2020

AbstractCystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent evidence indicates that CFTR plays a role in other cellular processes, namely in development, cellular differentiation and wound healing. Accordingly, CFTR has been proposed to function as a tumour suppressor in a wide range of cancers. Along these lines, CF was recently suggested to be associated with epithelial–mesenchymal transition (EMT), a latent developmental process, which can be re-activated in fibrosis and cancer. However, it is unknown whether EMT is indeed active in CF and if EMT is triggered by dysfunctional CFTR itself or a consequence of secondary complications of CF. In this study, we investigated the occurrence of EMT in airways native tissue, primary cells and cell lines expressing mutant CFTR through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors. Transepithelial electrical resistance, proliferation and regeneration rates, and cell resistance to TGF-β1induced EMT were also measured. CF tissues/cells expressing mutant CFTR displayed several signs of active EMT, namely: destructured epithelial proteins, defective cell junctions, increased levels of mesenchymal markers and EMT-associated transcription factors, hyper-proliferation and impaired wound healing. Importantly, we found evidence that the mutant CFTR triggered EMT was mediated by EMT-associated transcription factor TWIST1. Further, our data show that CF cells are over-sensitive to EMT but the CF EMT phenotype can be reversed by CFTR modulator drugs. Altogether, these results identify for the first time that EMT is intrinsically triggered by the absence of functional CFTR through a TWIST1 dependent mechanism and indicate that CFTR plays a direct role in EMT protection. This mechanistic link is a plausible explanation for the high incidence of fibrosis and cancer in CF, as well as for the role of CFTR as tumour suppressor protein.
A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
Authors: Benz Maximilian , Asperger Arndt , Hamester Meike , Welle Alexander , Heissler Stefan , Levkin Pavel A. 
Published: October 2020

AbstractAcceleration and unification of drug discovery is important to reduce the effort and cost of new drug development. Diverse chemical and biological conditions, specialized infrastructure and incompatibility between existing analytical methods with high-throughput, nanoliter scale chemistry make the whole drug discovery process lengthy and expensive. Here, we demonstrate a chemBIOS platform combining on-chip chemical synthesis, characterization and biological screening. We developed a dendrimer-based surface patterning that enables the generation of high-density nanodroplet arrays for both organic and aqueous liquids. Each droplet (among > 50,000 droplets per plate) functions as an individual, spatially separated nanovessel, that can be used for solution-based synthesis or analytical assays. An additional indium-tin oxide coating enables ultra-fast on-chip detection down to the attomole per droplet by matrix-assisted laser desorption/ionization mass spectrometry. The excellent optical properties of the chemBIOS platform allow for on-chip characterization and in-situ reaction monitoring in the ultraviolet, visible (on-chip UV-Vis spectroscopy and optical microscopy) and infrared (on-chip IR spectroscopy) regions. The platform is compatible with various cell-biological screenings, which opens new avenues in the fields of high-throughput synthesis and drug discovery.