bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarity in growth response of Aspergillus terreus isolates under mimic hydrothermal vent conditions suggests no physiological growth barrier between terrestrial and marine environments
Authors: Guo Sheng-Yu , Chiang Michael W.L. , Lin Wan-Rou , Hsieh Sung-Yuan , Phatthongkleang Thossaporn , Jones E.B. Gareth , Pang Ka-Lai 
Published: February 2025

Abstract
This study investigated the phylogeny of 17 isolates of Aspergillus terreus, cultured from soil, macroalgae, hydrothermal vent sediment in terrestrial and marine environments, and their growth response under combined effect of sea salt concentration (0 g l−1 or 30 g l−1), temperature (25 °C or 45 °C), pH (3 or 7). The isolates did not form clades corresponding to their ecological origin based on a combined phylogenetic analysis of five DNA regions (internal transcribed spacers of ribosomal DNA, calmodulin, β-tubulin, elongation factor 1-α, RNA-polymerase second large subunit). All isolates were able to grow under all tested conditions, including 45 °C/pH 3, environmental conditions possible at a hydrothermal vent site. The growth rate of the isolates was generally higher at 25 °C than at 45 °C and at pH 7 than at pH 3, and was similar at 0 g l−1 and 30 g l−1 sea salt concentrations. These results collectively suggest that the ocean is a sink of both marine and terrestrial isolates of A. terreus, which has the physiological and genetic capacities to grow in both environments.
AI-based character generation for disease stories: a case study using epidemiological data to highlight preventable risk factors
Authors: Mittenentzwei Sarah , Garrison Laura A. , Budich Beatrice , Lawonn Kai , Dockhorn Alexander , Preim Bernhard , Meuschke Monique 
Published: February 2025

Abstract
Data-driven storytelling has grown significantly, becoming prevalent in various fields, including healthcare. In medical narratives, characters are crucial for engaging audiences, making complex medical information accessible, and potentially influencing positive behavioral and lifestyle changes. However, designing characters that are both educational and relatable to effectively engage audiences is challenging. We propose a GenAI-assisted pipeline for character design in data-driven medical stories, utilizing Stable Diffusion, a deep learning text-to-image model, to transform data into visual character representations. This approach reduces the time and artistic skills required to create characters that reflect the underlying data. As a proof-of-concept, we generated and evaluated two characters in a crowd-sourced case study, assessing their authenticity to the underlying data and consistency over time. In a qualitative evaluation with four experts with knowledge in design and health communication, the characters were discussed regarding their quality and refinement opportunities. The characters effectively conveyed various aspects of the data, such as emotions, age, and body weight. However, generating multiple consistent images of the same character proved to be a significant challenge. This underscores a key issue in using generative AI for character creation: the limited control designers have over the output.
The crystal structure of N′,N″-[1,2-bis(4-chlorophenyl)ethane-1,2-diylidene]bis(furan-2- carbohydrazide), C24H16Cl2N4O4
Authors: Tian Wei , Huang Shuting , Huang Xinji , Lin Shijie , Chen Shaofeng , Wang Jingni 
Published: February 2025

Abstract
C24H16Cl2N4O4, monoclinic, P21/n (no. 14), a = 10.2264(4) Å, b = 16.1772(6) Å, c = 13.8429(6) Å, β = 102.463(5)°, V = 2236.13(16) Å3, Z = 4, R

gt
(F) = 0.0574, wR
ref(F
2) = 0.1588, T = 220(2) K.
The Power of Predication and Quantification
Authors: Zalta Edward N. 
Published: February 2025

Abstract
In this article, I show how two modes of predication and quantification in a modal context allow one to (a) define what it is for an individual or relation to exist, (b) define identity conditions for properties and relations conceived hyperintensionally, (c) define identity conditions for individuals and prove the necessity of identity for both individuals and relations, (d) derive the central definition of free logic as a theorem, (e) define the essential properties of abstract objects and provide a framework for defining the essential properties of ordinary objects, and (f) derive a theory of truth. I also describe my indebtedness to the work of Terence Parsons and take the opportunity to advance the discussion in connection with an objection raised to the theory of essential properties.
Grüne Fabrikplanung
Authors: Vollack Björn , Maiwald Martin , Mocker Ulrike , Kühn Mathias , Schmidt Thorsten 
Published: February 2025

Abstract
Das Projekt BeFaNa entwickelt ein zweistufiges System aus Selbsttest und darauf aufbauendem Beratungstool zur Förderung nachhaltiger Fabrikplanung. Der Selbsttest bietet Unternehmen einen einfachen Einstieg zur Bewertung ihres Status und zur Identifikation von Effizienzpotenzialen. Das Beratungstool ermöglicht die Identifikation, detaillierte Planung und Umsetzung nachhaltiger Maßnahmen, u. a. durch den Einsatz einer Technologiedatenbank. Der Fokus dieses Beitrags liegt auf der Vorstellung des Selbsttests. Durch den Transfer wissenschaftlicher Erkenntnisse in die Praxis unterstützt das Projekt Unternehmen bei der Erreichung von Nachhaltigkeitszielen und wirtschaftlichen Vorteilen. Langfristig trägt das Projekt zur Etablierung nachhaltiger Fabrikplanung sowie industrieller Symbiosen bei und stärkt sowohl die ökologische als auch wirtschaftliche Resilienz von Unternehmen.
Absicherung mechatronischer Systeme im Exterieur für die Automobilmontage
Authors: Lange Volker 
Published: February 2025

Abstract
Dieser Beitrag beschreibt das Konzept der frühzeitigen Absicherung mechatronischer Systeme für die Automobilmontage. Voraussetzung dafür sind u. a. Bediengeräte, die die mechatronischen Teilsysteme so steuern, wie dies später im Gesamtfahrzeug geplant ist. Damit kann die Absicherung auch erfolgen, wenn keine fahrfähigen Fahrzeug-Prototypen zur Verfügung stehen. Die Anwendung im Entwicklungsprozess für die Karosserieausstattung Exterieur wird an den Beispielen Fensterheber und Softtop-Verdeck erläutert.
Wie entsteht „Flow“ in einem Unternehmen?
Authors: Wendt Andreas 
Published: February 2025

Abstract
Wie entsteht Leidenschaft in einem Unternehmen? Eine Haltung und ein Leistungswille aller Beteiligten, Hindernisse zu überwinden und neue Chancen zu nutzen? Eine Eigendynamik, die aus unterschiedlichen Perspektiven und Fähigkeiten Leistung, Geschwindigkeit und Freude entwickelt? Führung ist das Schlüsselthema, das aber ebenso konsequente Arbeit an Prozessen, Strategie und Kundenwirksamkeit voraussetzt. Der Autor zeigt am Beispiel eines Automobilwerks, wie in achtjähriger, systematischer Führungsarbeit mit den Menschen der Charakter einer erfolgreichen Organisation entwickelt wurde, der bis heute prägend ist.
Does the level of psychological stress affect the death risk in the Russian population. Results of ESSE-RF and ESSE-RF2
Authors: Gomanova L. I. , Balanova Yu. A. , Shalnova S. A. , Ivlev O. E. , Kutsenko V. A. , Evstifeeva S. E. , Imaeva A. E. , Kapustina A. V. , Karamnova N. S. , Kotova M. B. , Maksimov S. A. , Muromtseva G. A. , Shvabskaya O. B. , Yarovaya E. B. , Kontsevaya A. V. , Drapkina O. M. 
Published: February 2025

Aim. To study the associations of psychological stress (PS) with the risk of fatal and non-fatal events depending on anamnestic features in the Russian population.Material and methods. Representative samples of the population aged 25-64 years were examined within the ESSE-RF and ESSE-RF2 and included in the prospective cohort (15 regions, n=23815, median follow-up — 7,6 years) were analyzed. PS was assessed using the Perceived Stress Scale-10. PS levels are defined as follows: low — 0-11, moderate — 12-19, high — 20-40. The endpoints were all-cause death and composite endpoint (fatal and/or non-fatal cardiovascular events (CVEs)). Statistical analysis was performed in R 4.2.Results. In multivariate analysis, high PS level was associated with a 1,45-fold increase in the risk of all-cause death (p<0,001), and a 1,4-fold increase in the risk of fatal and/or non-fatal CVEs (p=0,001). A history of noncommunicable diseases (NCDs) is an aggravating factor for individuals with high PS levels in relation to the risk of fatal and/or non-fatal CVE — among participants with NCDs, the association of PS and prognosis was stronger than among participants without NCDs (p=0,023). At the same time, the number of NCDs did not change the association of PS and prognosis.Conclusion. The negative impact of PS on the prognosis in the Russian cohort emphasizes the importance of its detection and correction within preventive examinations of the population, as well as the management of patients with NCDs. Inclusion of these positions in regulatory documents will optimize patient routing and reduce the risk of adverse outcomes in the population.
Outpatient monitoring of patients with lipoprotein metabolism disorders and other lipidemias by a general practitioner in primary care. Guidelines
Authors: Drapkina O. M. , Boytsov S. A. , Ershova A. I. , Shepel R. N. , Osipova O. A. , Meshkov A. N. , Blokhina A. V. , Ipatov P. V. , Balakhonova T. V. , Savchenko E. D. 
Published: February 2025

The guideline describes the management of outpatient monitoring of patients with lipid metabolism disorders by a general practitioner. The following is presented: the approximate volume and frequency of paraclinical investigations, information on the diagnosis, treatment and prevention of disease complications. As practical experience is accumulated, the guidelines will be adjusted.The guidelines are intended for general practitioners, family doctors, as well as for mid-level health providers working with the above-mentioned doctors, for paramedics performing the doctor functions. The guidelines can be used by public health physicians, heads of primary health care facilities and their divisions.
Qualidade de vida de cuidadores de pessoas idosas: adaptação cultural da Quality of Life Scale for Informal Carers for Older Adults
Authors: Menegatti Frisanco Fernanda , Blascke Barbiere Melina Renata , De Souza Orlandi Fabiana 
Published: February 2025

Objetivo: traduzir e adaptar culturalmente a Quality of Life Scale for Informal Carers for Older Adults, para o Brasil. Método: Trata-se de estudo metodológico de adaptação cultural da referida escala, que seguiu as seguintes etapas: tradução inicial, síntese das traduções, retrotradução, revisão por um comitê de especialistas e pré-teste. Todos os preceitos éticos foram respeitados. Resultados: Foram feitas duas traduções da escala original, estabelecendo-se posteriormente a versão consensual, a qual foi retrotraduzida por outro tradutor independente. A seguir realizou-se a revisão pelo comitê de especialistas composto por seis juízes. Dos 24 itens da escala, a maioria dos itens obteve índice de validade de contéudo acima de 0,78, com exceção de três, os quais foram revisados. Em seguida realizou-se o instrumento que foi pré testado por 35 cuidadores informais de pessoas idosas, seis participantes refereriram dúvidas em duas questões “oito e vinte quatro”foram esclarecidas as dúvidas e após verificou-se boa clareza, compreensão e aceitabilidade. Além disso, a consistência interna foi satisfatória, já que se obteve alfa de Cronbach ≥ 0,70 para maioria dos domínios do instrumento. Conclusão: A Quality of Life Scale for Informal Carers for Older Adults está agora traduzida e adaptada culturalmente para o português brasileiro.
Perceived knowledge, treatment approaches and predictors of referral practices in myofascial pain syndrome of the temporomandibular joint
Authors: Van Der Colff Hyla , Docrat Aadil , Singh Deepak , Pillay Julian David 
Published: February 2025

Myofascial Pain Syndrome (MFPS) of the head and neck is a frequently misdiagnosed cause of Temporomandibular Disorders (TMDs). In South Africa, literature regarding general dental practitioners’ (GDPs) knowledge/management of TMDs associated with MFPS is limited.
Assessing orthodontic treatment outcome of patients treated by orthodontic residents – using the Peer Assessment Rating index
Authors: Julyan Johan Christian , Bellardie Haydn , Harris Angela 
Published: February 2025

Assessing the degree of improvement is important for establishing the standard of care provided by an individual orthodontist or tertiary care institution. This study aimed to assess the orthodontic treatment outcomes of patients treated by residents in a postgraduate orthodontic programme at a University in South Africa.
Reseña. Teresa Zapata Fernández de la Hoz, La Corte de Felipe IV se viste de fiesta. La entrada de Mariana de Austria (1649), Valencia, Universidad de Valencia, 2016. 419 páginas
Authors: Moya García María 
Published: February 2025

Reseña del libro: Teresa Zapata Fernández de la Hoz, La Corte de Felipe IV se viste de fiesta. La entrada de Mariana de Austria (1649), que analiza el proceso nupcial de la boda de Mariana de Austria y Felipe IV, haciendo hincapié en la entrada triunfal de la reina en Madrid.
Antineutralidad: An unknown and unpublished book of Diego de Saavedra Fajardo
Authors: Monostori Tibor 
Published: February 2025

The Antineutralidad is an anonymous, legal-political treatise in manuscript from 1640, dedicated to the count-duke of Olivares, stored in at least two locations: Brussels and Madrid. A variety of reasons are provided, arguing that it is a mature masterpiece of Diego de Saavedra Fajardo, in cultural significance comparable to the Empresas políticas, his other principal writing.
Las figuras heráldicas en los libros de caballerías
Authors: López-Fanjul de Argüelles Carlos 
Published: February 2025

Se analizan en detalle las figuras en los escudos de los personajes de 35 libros de caballerías impresos en el siglo XVI, que se distribuyen por igual en dos grupos: 1) formas tomadas del repertorio heráldico convencional, a veces utilizadas con significado simbólico, y 2) representaciones de sucesos trazados con total realismo (“escenas”) de intención alusiva o alegórica, derivadas de las introducidas en la heráldica castellana auténtica a partir del último tercio del siglo XV que gozaron de creciente aceptación a lo largo del XVI. Un buen número de estas figuras fueron usadas con propósitos semejantes en las concesiones regias de armas y en los escudos de ficción, apuntando a un origen común de la imaginación heráldica de sus inventores. Se estudian pormenorizadamente las adopciones de escudos novelescos por parte de individuos reales y el fenómeno inverso de transferencia de escudos auténticos a personajes literarios.
La divisa o empresa de Alfonso V el Africano, rey de Portugal: nueva lectura e interpretación
Authors: López Poza Sagrario 
Published: February 2025

La divisa del rey Alfonso V de Portugal (1432–1481), de la dinastía de Avís, conocido como el Africano, ha sido hasta ahora mal comprendida por basarse en vestigios que no tenían completo el mote, así como por una explicación deficiente del sentido del motivo pictórico. Este trabajo aporta el verdadero mote de la divisa y una interpretación del conjunto de los dos elementos (mote y pictura) en consonancia con los hábitos y prácticas de la Emblemática en el siglo XV.
Las glosas de los Symbola Heroica de Salomon Neugebauer: I. Perfil biográfico y literario
Authors: García Román Cirilo 
Published: February 2025

Este trabajo ofrece, en esta primera parte, un perfil biográfico y literario del escritor prusiano Salomon Neugebauer (¿ca. 1574 - † 1625?); proponemos la actual ciudad checa de Kadaň (lat. Cadānum; alem. Kaaden) como su localidad natal, y esbozamos la estructura de las glosas (subscriptio) de sus Symbola heroica.
Una sátira española sobre la supuesta postura pro francesa de la reina consorte María Luisa de Orleans, esposa de Carlos II de España
Authors: Terán Elizondo María Isabel , Lira Saucedo Salvador Alejandro 
Published: February 2025

El objetivo del presente artículo es explicar, desde una perspectiva filológica e histórica cultural, el manuscrito titulado Copia de un papel que se halló en un escritorio de la reina, nuestra señora doña María Luisa de Borbón de Francia, en principio hallado en la denuncia y proceso del Santo Oficio de México al mestizo Ignacio de San Juan Salazar de Puebla de los Ángeles. La indagación llevó a encontrar 22 ejemplares del referido manuscrito, en diferentes repositorios documentales entre la Península Ibérica y América, de los que la mayoría carecen de fecha y firma, así como paratextos que pudieran dilucidar al verdadero autor. Además de dar a conocer el papel y destacar su importancia, en este trabajo interesa develar algunas de sus características más relevantes, exponer los argumentos por los que es una sátira, y mostrar cómo, en una especie de "espejo de princesas" invertido, el desconocido autor intenta convencer a María Luisa de Orleans de las supuestas "virtudes" políticas de una reina, pero de una que es leal a su patria de origen y no a la que gobierna, lo que a los ojos de sus súbditos españoles la convertía en una traidora, pasando así, de ser la aparente protagonista del escrito, a la principal víctima de las supuestas maquinaciones políticas descritas en él.
Estimando y contrastando la extensión de las formaciones vegetales microtermales del Perú de inicios del siglo XX
Authors: Zelada Gárate Humberto , Reynel-Rodríguez Carlos Augusto 
Published: February 2025

Augusto Weberbauer publicó en 1922 el primer Mapa de Vegetación del Perú, en el que representó y describió 25 formaciones vegetales, las cuales agrupó en seis categorías, considerando ámbitos altitudinales definidos en función de su temperatura. Dentro de esas categorías están las formaciones microtermales que, generalmente, se encuentran por encima de los 3400 msnm y tienen amplia distribución latitudinal a lo largo de los Andes peruanos. En aras de revalorizar aquel mapa histórico, en primer lugar, se presentan los resultados de la digitalización y estimación de la extensión de las cuatro formaciones vegetales microtermales identificadas por Weberbauer y, en segundo lugar, se exponen los hallazgos del contraste cartográfico realizado entre dichas formaciones microtermales y las coberturas vegetales altoandinas clasificadas en el mapa más actual en el Perú sobre esta temática. En ese sentido, se aprecia que el investigador alemán cartografió una extensión de 183.445,30 km² para el conjunto de las cuatro formaciones vegetales microtermales: formaciones típicas altoandinas (61,67%); estepa herbácea microtérmica (17,93%); tolar microtérmico (17,47%); los glaciares y la nieve perpetua (2,93%). Asimismo, en la comparación cartográfica se observó que el 63,92% del territorio que actualmente ocupan las coberturas vegetales altoandinas del Perú coincide con lo cartografiado e identificado por Weberbauer como formaciones vegetales microtermales. Estos resultados contribuyen a comprender la evolución de este tipo de formaciones vegetales, las cuales están sufriendo una fuerte presión por la sumatoria del cambio climático y los impactos antrópicos.
Predictive models for patient-reported outcomes (PROs) in elective spine surgery: a systematic review
Authors: Lemel Hannah , Shin David , Meade Seth , Lapin Brittany , Mroz Thomas , Steinmetz Michael , Habboub Ghaith 
Published: February 2025

Aim: A growing body of literature reports on prediction models for patient-reported outcomes of spine surgery, carrying broad implications for use in value-based care and decision making. This review assesses the performance and transparency of reporting of these models.
Methods: We queried four studies reporting the development and/or validation of prediction models for patient-reported outcome measures (PROMs) following elective spine surgery with performance metrics such as the area under the receiver operating curve (AUC) scores. Adherence to transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD-AI) guidelines was assessed. One representative model was selected from each study.
Results: Of 4,471 screened studies, 35 were included, with nine development, 24 development and evaluation, and two evaluation studies. Sixteen machine learning models and 19 traditional prediction models were represented. Oswestry disability index (ODI) and modified Japanese Orthopaedic Association (mJOA) scores were most commonly used. Among 29 categorical outcome prediction models, the median [interquartile range (IQR)] AUC was 0.79 [0.73, 0.84]. The median [IQR] AUC was 0.825 [0.76, 0.84] among machine learning models and 0.74 [0.71, 0.81] among traditional models. Adherence to TRIPOD-AI guidelines was inconsistent, with no studies commenting on healthcare inequalities in the sample population, model fairness, or disclosure of study protocols or registration.
Conclusion: We found considerable variation between studies, not only in chosen patient populations and outcome measures, but also in their manner of evaluation and reporting. Agreement about outcome definitions, more frequent external validation, and improved completeness of reporting may facilitate the effective use and interpretation of these models.
Exploring YAP1-related TIME in SCLC: implications for survival and treatment response to immuno-chemotherapy
Authors: Chen Yu-Qing , Tan Jia-Xiong , Gao Ling-Ling , Yang Jia-Xing , Huang Jie , Yang Jin-Ji , Zhao Qiang 
Published: February 2025

Aim: Small-cell lung cancer (SCLC) is usually diagnosed as an advanced stage with a poor outcome. SCLC has limited response to immunotherapy due to the absence or lack of immune cell infiltration, so studying its tumor immune microenvironment (TIME) is essential.
Methods: The study involved patients with extensive-stage small-cell lung cancer (ES-SCLC) diagnosed at the Guangdong Lung Cancer Institute between January 2018 and April 2022 who had received the atezolizumab/carboplatin/etoposide (ECT) treatment. We used multi-immunohistochemistry (mIHC) to assess the prognostic value of YAP1 and TIME in SCLC, with results confirmed using public data.
Results: 15 patients with sufficient baseline biopsy samples were included in this study. The total population of YAP1-positive cells is inversely related to progression-free survival (PFS) and shows a potential negative correlation with overall survival (OS). CD56-positive cells are the primary components of TIME in SCLC tumor parenchyma and stroma. The total population and cell density of YAP1-positive cells are significantly positively correlated with CD4-positive cells. Furthermore, in the tumor parenchyma, both the proportion and the cell density of YAP1-positive cells are positively correlated with that of FOXP3-positive cells. The total population of CD56-positive cells showed a negative correlation trend with YAP1-positive cells but without significant difference.
Conclusion: YAP1 has shown prognostic value in SCLC patients receiving ECT regimen treatment. The high expression level of YAP1 seems related to the inhibitory TIME. However, some prospective studies with larger populations are warranted.