bluuebunny/crossref_metadata_2025_split huggingface dataset:
Student Pleasure Attitude and Interest in Spending Time Learning Science Against Student Cognitive Learning Outcomes
Authors: Fadilah Nur , Efendi Nur 
Published: October 2020

This study aims to analyze the relationship between students 'attitudes in science and cognitive learning outcomes based on 2 indicators that is enjoyment of science lessons and leisure interest in science. This type of quantitative research with a survey method. The instrument used was a questionnaire which was tested through the google form application. The results showed that enjoyment of science lessons was categorized as good with a percentage of 54%. Leisure interest in science is categorized quite good with a percentage of 42%. Based on the correlation analysis of enjoyment of science lessons and learning outcomes, it shows a positive correlation with a correlation level of 0.607 which is classified as a strong correlation. The correlation of leisure interest in science and learning outcomes shows a positive correlation with a correlation level of 0.499 which is classified as moderate correlation. Meanwhile, the correlation between the two indicators shows a positive correlation with the level of correlation of 0.776 which is classified as a strong correlation. It can be concluded that the students' attitudes towards science at MTs Muhammadiyah 1 Taman based on these indicators are classified as having positive attitudes and are categorized as good.
How COVID changed surgical acute inflammatory diseases and surgeons clinical practice during the first wave of COVID-19
Authors: Guadalajara Hector , Nova Jose Luis Muñoz de , Gonzalez Saul Fernandez , Yiasemidou Marina , Rico Maria Recarte , Juez Luz D , Septiem Javier Garcia , Jara Pablo Galindo , Virosta Mariana Garcia , Martinez Eduardo Lobo , Perez Elena Martin , Olmo Damian Garcia 
Published: October 2020

Abstract
BackgroundAnecdotal evidence suggests that community infection control measures during the COVID-19 outbreak have modified the number and natural history of acute surgical inflammatory processes (ASIP - appendicitis, cholecystitis, diverticulitis and perianal abscesses) admissions. This study aims to evaluate the impact of the COVID-19 pandemic on the presentation and treatment ASIP and quantify the effect of COVID-19 infection on the outcomes of ASIP patients. MethodsThis was a multicentre, comparative study, whereby ASIP cases from March 14th to May 2nd 2019 acted as historical controls for the cohort of patients with the same pathology during the COVID-19 pandemic. Data regarding patient and disease characteristics as well as outcomes, were collected from sixteen centres in Madrid, and one in Seville (Spain).ResultsThe number of patients treated for ASIP in 2019 was 822 compared to 521 in 2020. This reduction occurs mainly in patients with mild cases, while the number of severe cases was similar. ConclusionsThe number of ASIP cases treated during the pandemic was reduced by more than one third mainly due to a dramatic reduction in mild cases. This also has represented a selection of severe cases. We also found a more conservative approach to the patients this year, non-justified by clinical circumstances.The positive COVID-19 status itself did not have a direct impact on either morbidity or mortality. This is an interesting finding which if confirmed through future research with a larger sample size of COVID-19 positive patients, can expedite the recovery phase of acute surgical services.
Myricetin and its derivative M10, myricetin-3-O-β-d-lactose sodium salt, modify the composition of gut microbiota in mice with chronic ulcerative colitis
Authors: Miao Rong-Rong , Zhan Sheng , Hu Xue-Tao , Zhou Xiao-Ling , Cui Shu-Xiang , Qu Xian-Jun 
Published: October 2020

Abstract
Background

Previous studies revealed that Myricetin and derivative M10, Myricetin-3-O-β-d-lactose sodium salt, prevented chronic ulcerative colitis (UC) in mice. We investigated whether the inhibitory effects of Myricetin and M10 on UC were associated to the modification of intestinal microbiota. Samples of intestinal microbiota were collected from the ileocecum of UC mice which demonstrated response to the treatment of Myricetin and M10. Gut microbiota was analyzed by 16S rDNA sequencing assay.

Results

UC model mice demonstrated the increases of Firmicutes and Actinobacteria as compared to healthy control mice. Oral M10 and Myricetin normalized the composition of Firmicutes and Actinobacteria. At genus level, the effect of M10 and Myricetin on ulcerative colitis was strongly associated to the increase of probiotics, such as Akkermansia, and the inhibition of pathogenic microorganisms, such as Ruminococcus and Parabacteroides. Myricetin’s derivative M10 significantly increased both biosynthesis and degradation activities, resulting to strong improvements of the metabolism of sulfur, pyruvate, steroid biosynthesis and unsaturated fatty acid biosynthesis in gut microenvironment.

Conclusions

Natural product Myricetin and its derivative M10 could modify the modification of gut microbiota in UC mice. Combined with pharmacologic effects of Myricetin and M10 in these UC mice, we conclued that the effects of Myricetin and M10 on UC were associated to the modification of intestinal microbiota in the environment of chronic ulcerative colitis.
LHX2 facilitates the progression of nasopharyngeal carcinoma via activating the autocrine secretion of FGF1
Authors: Xie Tao , Wang Baiyao , Zheng Jieling , Tian Yunhong , Li Rong , Huang Xiaoting , Lin Jie , Jian Haifeng , zhang Jian , Yuan Yawei 
Published: October 2020

Abstract
Background: Distant metastasis and recurrence remain the obstacle for nasopharyngeal carcinoma (NPC) treatment in clinical, unfortunately, the molecular events underlying NPC growth and metastasis are poorly understood. Methods: The expression level and prognostic value of LHX2 in pan-cancer were analized in TCGA database. The LHX2 expression both in protein and RNA levels in NPC tissues and normal tissues was determined by western blot, qRT-PCR and immunohistochemistry. The roles of LHX2 in oncogenesis were determined using CCK-8, colony formation assays, EdU assay, wound healing assays,transwell assay as well as in vivo mouse model.Bioinformatics analysis, the Gene Set Enrichment Analysis, Luciferase Reporter Assays and Chromatin Immunoprecipitation Assays were applied to identify the downstream effector of LHX2. The activation of indicated signal pathways were measured by western blot. Results: The LIM-homeodomain transcription factor 2 (LHX2) expression was increased in many solid tumors and was associated with poor progression based on the data from TCGA database.LHX2 levels was also significantly upregulated in NPC tissues and cell lines.Ectopic expression of LHX2 dramatically promoted the cell viability, colony formation efficiency, migratory and invasive ability of NPC cells both in vitro and in vivo. In mechanism, the Fibroblast Growth Factor 1 (FGF1) was confirmed transcriptionally regulated by LHX2 and mediated LHX2-induced tumor-promoting effects. The elevated expression of FGF1 by LHX2 activated the phosphorylation of STAT3, ERK1/2 and AKT/ser9-GSK3β/β-catenin signal pathway, leading to the increased proliferation ability and epithelial-to-mesenchymal transition (EMT). Treating NPC cells with FGF1-conditioned medium or human recombinant FGF1 accelerated tumor growth and metastasis, which could be blocked by tyrosine kinase inhibitor, AZD4547. \Conclusions: Our study provides mechanistic insight into how LHX2/FGF1 acts as a sufficient regulator pathway in NPC proliferation and metastasis, and the FGF1/FGFR1/2 trapping may contribute to the development of a novel target for NPC therapy.
Disaster Preparedness Should Represent an Augmentation of the Everyday Trauma System – But Are We Prepared?
Authors: Jørgensen Jørgen Joakim , Monrad-Hansen Peter Wiel , Gaarder Christine , Næss Pål Aksel 
Published: October 2020

Abstract

IntroductionMass casualty incidents (MCI) range from natural disasters to terrorist attacks. The increased frequency, geographical spread and the heterogenicity in type of terror incidents, challenge healthcare systems all over the world. Trauma systems constitute the base upon which disaster preparedness is being build. The largest MCI in Norway took place 22 July 2011 and several lessons were learnt including the importance of having designed the everyday trauma infrastructure to be able to increase activity and adjust according to needs. Norway is sparsely populated, with a national trauma system consisting of four regional trauma centers (TCs) and 35 acute care hospitals treating trauma (non-trauma centers; NTCs) We wanted to assess how well hospitals fill the national trauma system requirements for competence, and the degree of awareness of existing MCI plans.MethodsWe conducted a cross-sectional survey of the on-call trauma team in all 39 Norwegian hospitals during two time periods: July-August (HS; holiday season) and September – June (NHS; non-holiday season). A standardized questionnaire was used to evaluate the MCI preparedness.ResultsA total of 347 trauma team members participated with 173 during HS and 174 during NHS. Over 95% of the team members were aware of the hospital MCI plan, only half had read the plan during the last 6 months, whereas 63% at the TCs and 74% at NTCs were confident with their designated role in the event of an MCI. Trauma team exercises were conducted regularly and 86% had ever participated, primarily residents and nurses. Only 63% at the TCs and 53% at the NTCs had participated in an MCI exercise. The proportion of resident surgeons and anesthetists with >4 years clinical experience was significantly higher in TCs (88% and 63%) than in NTCs (27% and 17%). At NTCs 38% of the resident surgeons were on call from home after working hours. All the on-call consultant surgeons were at home after working hours, leaving interns in charge at several of the hospitals. All resident surgeons at the TCs were ATLS providers compared to 64% at the NTCs and almost 90% of the consultant surgeons had participated in advanced trauma surgical courses. ConclusionDespite increased focus on disaster preparedness at a national level after the 2011 attacks, we identified limited compliance with trauma system requirements concerning competency and training. Strict guidelines to secure immediate notification and early presence of consultants whenever a situation that might turn into an MCI occurs should be a prerequisite. The awareness and content of existing MCI plans should be continuously improved to be able to meet the challenges of future MCIs.
Efficacy and Safety of Luseogliflozin in Patient with Type 2 Diabetes Complicated by Hepatic Dysfunction
Authors: Seino Hiroaki 
Published: October 2020

Abstract
Background: Improvements in glycemic control and hepatic function are clinically important goals in the treatment of patients with type 2 diabetes mellitus complicated by hepatic dysfunction. The favorable effects of the sodium-glucose co-transporter inhibitor luseogliflozin on hepatic dysfunction were anticipated for humans. Nevertheless, few clinical studies have confirmed its real-world efficacy on hepatic dysfunction. This trial was conducted to assess the safety and efficacy of luseogliflozin in patients with type 2 diabetes mellitus complicated by hepatic dysfunction.Methods: This prospective, single-site, single-arm, open-label trial included 55 subjects. Subjects were administered with luseogliflozin and observed for 52 weeks. The primary endpoints were the change and percent change in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GTP), and hemoglobin A1c (HbA1c) from baseline to week 52. The secondary endpoints included body weight, body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose (FPG), homeostatic model assessment beta (HOMA-β), homeostatic model assessment of insulin resistance (HOMA-IR), ferritin, Mac-2 binding protein (M2-BP), fatty liver index (FLI), fibrosis-4 (FIB-4) index, type IV collagen 7S domain, nonalcoholic fatty liver disease (NAFLD) fibrosis score, high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6).Results: AST, ALT, γ-GTP, and HbA1c significantly decreased from baseline to week 52. Body weight, BMI, waist circumference, and FPG also significantly decreased. HOMA-IR significantly decreased but HOMA-β was unchanged. FLI, ferritin, M2-BP, and NAFLD fibrosis scores significantly decreased whereas the FIB-4 index and type IV collagen 7S domain did not significantly change. The hs-CRP and IL-6 levels did not significantly change.Conclusion: Luseogliflozin administration in T2DM patients with hepatic dysfunction was well tolerated, improved hepatic function, reduced liver fat, and attenuated liver injury and fibrosis. The present study might help establish a therapeutic approach for T2DM patients with hepatic dysfunction induced by SGLT2 inhibitors.Trial registration: This study was registered under the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR) (No. UMIN000025808) and the Japan Registry of Clinical Trials (No. jRCTs021180017).
Volumetric modulated arc therapy (VMAT) is superior to intensity modulated radiotherapy (IMRT) for liver sparing in SBRT for hepatocellular carcinoma
Authors: Kundel Yulia , Korzets Yasmin , Weinstock-Sabbah Miriam , Moore Assaf , Gordon Noa , Stemmer Salomon M. , Popovtzer Aaron , Brenner Baruch , Fenig Eyal , Allen Aaron M. 
Published: October 2020

Abstract
Background: The best delivery modality of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) from a technical point of view is still a matter of debate. The purpose of this study was to compare planning parameters with volumetric modulated arc therapy (VMAT) to static intensity modulated radiotherapy (IMRT) in treatment of HCC treated with SBRT. Methods: Twenty patients (pts) with localized HCC who were treated with SBRT were re-planned using two different radiation techniques: IMRT and VMAT. Patients with Child A cirrhosis received 45-54 Gy in 3 fractions and 5 pts with Child B cirrhosis received 30 Gy in 5 fractions. Planning was optimized to minimize doses to organs at risk (OAR) without compromising coverage of the planning treatment volume (PTV). VMAT and IMRT plans were compared using the conformity index (CI), homogeneity index of the PTV and monitor units (MUs) for time of treatment delivery, and other dose volume histogram (DVH) metrics.Results: The CI of VMAT plans were superior to those of IMRT(1.11±0.05 vs 1.18±0.06 (p <0.05) The MUs were significantly lower for VMAT (423.78±50.65) than for IMRT (890±160.68) (p <0.01). Stomach max dose, normal liver V15 Gy, normal liver mean dose were also decreased with VMAT planning. This was achieved without increased :V30 Gy of duodenum and small bowel , 10 cc(Gy) of duodenum, mean dose of right kidney and cord max dose . Conclusion: PTV coverage was more conformal with VMAT planning, with lower MUs and shorter delivery time compared to IMRT in all pts. Moreover VMAT planning was more effective than IMRT planning in the sparing of normal liver and stomach.
WITHDRAWN: Multimodal genetic features correlate with poor response to neoadjuvant chemoradiotherapy and high recurrence risk in Chinese patients with stage IB-IIA cervical cancer
Authors: Wei Yuchun , Wei Chuqing , Liang Chen , Liu Ning , Fang Zhenhao , Yin Jiani C. , Pang Jiaohui , Ou Qiuxiang , Wu Xue , Wang Xiaonan , Mu Dianbin , Shao Yang , Yu Jinming , Yuan Shuanghu 
Published: October 2020

Abstract
Background Response of cervical cancer patients to neoadjuvant therapy differs from person to person. It remains unclear whether genetic alterations can predict response to neoadjuvant therapy and disease-free survival in cervical cancer.Methods 62 Chinese patients with stage IB-IIA cervical cancer were included in this study. Pre-treatment tumor tissues were profiled using a targeted next-generation sequencing assay. Genetic alterations were compared with those identified in the Western populations using the TCGA database. Pathological response and disease-free survival (DFS) were evaluated and their correlations with genetic alterations were analyzed.Results Genetic alterations in PIK3CA were prevalent in both Chinese and Caucasian populations. The mutation frequencies of TERT, POLD1, NOS2, and FGFR3 were significantly higher in Chinese patients whereas RPTOR, EGFR, and TP53 were frequently mutated in Caucasian patients. Germline mutations were identified in 13 out of 62 Chinese patients and 57% of them occurred in DNA repair genes, such as BRCA1/2, TP53 and PALB2. High tumor mutation burden (TMB), TP53 polymorphism (rs1042522) and KEAP1 mutations were found to be associated with poor response to neoadjuvant therapy. KEAP1 mutations, PIK3CA-SOX2 co-amplification, TERC amplification and TYMS polymorphism were associated with higher relapse rates of cervical cancer.Conclusion The similarity and difference of mutation landscape of Chinese and Caucasian patients suggested genetic background played a role in shaping the architecture of cervical cancer mutations. The associations of mutation feature of cervical cancer with patient response and tumor recurrence risk provided rationale to further validate and explore potential biomarkers for cervical cancer patients.
Adding Pre-procedural Glycemia to the Mehran Score Enhances Its Ability to Predict Contrast-induced Acute Kidney Injury in Patients With and Without Diabetes Undergoing Percutaneous Coronary Intervention
Authors: Nusca Annunziata , Mangiacapra Fabio , Sticchi Alessandro , Polizzi Giovanni , D’Acunto Giulia , Ricottini Elisabetta , Melfi Rosetta , Gallo Paolo , Miglionico Marco , Giannone Sara , Ussia Gian Paolo , Grigioni Francesco 
Published: October 2020

Abstract
Background: The Mehran score is the most widely accepted tool for predicting contrast-induced acute kidney injury (CI-AKI), a major complication of percutaneous coronary intervention (PCI). Similarly, abnormal fasting pre-procedural glycemia (FPG) represents a modifiable risk factor for CI-AKI, but it is not included in current risk models for CI-AKI prediction. We sought to analyze whether adding FPG to the Mehran score improves its ability to predict CI-AKI following PCI.Methods: We analyzed 671 consecutive patients undergoing PCI (age 69 [63,75] years, 23% females), regardless of their diabetic status, to derive a revised Mehran score obtained by including FPG in the original Mehran score (Derivation Cohort). The new risk model (GlyMehr) was externally validated in 673 consecutive patients (Validation Cohort) (age 69 [62,76] years, 21% females). Results: In the Derivation Cohort, both FPG and the original Mehran score predicted CI-AKI (AUC 0.703 and 0.673, respectively). The GlyMehr score showed a better predictive ability when compared with the Mehran score both in the Derivation Cohort (AUC 0.749, 95%CI 0.662-0.836; p=0.0016) and the Validation Cohort (AUC 0.848, 95%CI, 0.792–0.903; p=0.0008). In the overall population (n=1344), the GlyMehr score confirmed its independent and incremental predictive ability regardless of diabetic status (p≤0.0034) or unstable/stable coronary syndromes (p≤0.0272). Conclusions: Adding FPG to the Mehran score significantly enhances our ability to predict CI-AKI. The GlyMehr score may contribute to improve the clinical management of patients undergoing PCI by identifying those at high risk of CI-AKI and potentially detecting modifiable risk factors.
Association between dietary lysine intake and lean body mass among young Indian women
Authors: Aggarwal Renuka , Bains Kiran , Kaur Harpreet 
Published: October 2020

Abstract
Background: Lysine is deficient in cereal based traditional Indian diets. Inadequate lysine intakes by Indian population may influence their lean body mass, thereby posing a risk to metabolic diseases and poor fitness. This study investigated associations between intakes of protein and lysine and its existing association with lean mass among Indian women. Methods: The study was carried out among 473 women. Dietary intake of protein and lysine was estimated via 24h recall. Lean body mass based on body composition analysis was assessed. Associations between intakes of protein and lysine with fat mass index, muscle mass index and fat free mass index were analyzed by Pearson's correlation coefficients. Results: Among women positive and significant associations were found between intake of lysine and muscle mass index(r=0.221) and fat free mass index(r= 0.371). An inverse association was found between fat mass index and lysine intake(r= - 0.278). Furthermore, the dietary adequacy for protein and lysine was only 71.88 and 39.41% against the recommended levels. Conclusions: Diets of the studied population was lacking in lysine. Among women, higher lysine intakes may decrease body fat gain and increase lean body mass suggesting better physical fitness and decreased risk of metabolic diseases.
Dienogest exerts its anti-endometriotic effect throughthe direct suppression of matrix metallopeptidases
Authors: Honda Hiroshi , Nishimichi Norihisa , Yamashita Michinori , Akimoto Yumiko , Tanimoto Hirotoshi , Teramoto Mitsue , Teramoto Hideki , Yokosaki Yasuyuki 
Published: October 2020

Abstract
Background: Endometriosis, which affects up to 10% women of reproductive age, is defined by the presence of ectopic endometrial tissue outside the uterus. The current key drug of hormonal therapies for endometriosis is dienogest, which is a progestin with high specificity for the progesterone receptor. Although many findings about the anti-endometriotic effect of dienogest on endometriosis have been reported, the precise mechanisms of dienogest's anti-endometriotic effect remain unknown. Methods: To investigate the direct anti-endometriotic effect of dienogest on endometriotic cells, we determined and compared the genome-wide gene expression profiles of endometriotic stromal cells treated with dienogest (Dienogest group) and those not treated with dienogest (Control group) and then performed a pathway analysis using these data. To test the microarray data, we performed real-time RT-PCRs for matrix metallopeptidase (MMP)-1, MMP-3, MMP-10, and TIMP-4.Results: Six-hundred forty-seven genes were revealed to be differentially expressed between the Dienogest and Control groups. Of them, 314 genes were upregulated and 333 genes were downregulated in the Dienogest group compared to the Control group. We identified 20 canonical pathways that are significantly distinct in the Dienogest group versus the Control group. Among the 20 canonical pathways, MMPs including MMP-1, -3, and -10 were found to be the most involved genes. Conclusions: Our results suggest that dienogest may exert its anti-endometriotic effect through the direct suppression of MMPs.