bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einsatz von sedierenden Medikamenten und bewegungseinschränkenden Maßnahmen bei Patienten mit Demenz im Akutkrankenhaus
Authors: Lüdecke Daniel , Kofahl Christopher 
Published: February 2020

Zusammenfassung
Hintergrund
Auf Menschen mit Demenz mit stationär behandlungsbedürftiger Akuterkrankung ist der Großteil der Akutkrankenhäuser kaum vorbereitet. Dies birgt die Gefahr der Überforderung für das Personal. Demenzerkrankungen sind der häufigste Grund dafür, dass Krankenhauspersonal sedierende Medikamente verabreicht und bewegungseinschränkende Maßnahmen einsetzt.

Zielsetzung
Die vorliegende Studie untersucht Faktoren, die den (unangemessenen) Einsatz von sedierenden Medikamenten und bewegungseinschränkenden Maßnahmen beeinflussen.

Methoden
Eine nichtrandomisierte Fall-Kontroll-Studie wurde in 2 internistischen Abteilungen in Hamburg durchgeführt. In der Interventionsgruppe wurde ein spezielles Versorgungskonzept für Menschen mit Demenz implementiert. Die Versorgungsart in der Kontrollgruppe entsprach der Regelversorgung. Mit logistischen Regressionen wurden Zusammenhänge zwischen Faktoren wie Alter, Demenzschweregrad, Verhaltensauffälligkeiten, Barthel-Index oder Versorgungsart und dem Einsatz sedierender Medikamente bzw. bewegungseinschränkender Maßnahmen untersucht.

Ergebnisse
Herausfordernde Verhaltensweisen (OR = 1,32) und die Zugehörigkeit zur Kontrollgruppe (OR = 1,94) sind signifikant mit dem Einsatz sedierender Medikamente assoziiert. Ein geringerer Barthel-Index, längere Aufenthaltsdauer und die eine Behandlung in der Kontrollgruppe sind signifikant mit einer höheren Wahrscheinlichkeit des Einsatzes bewegungseinschränkender Maßnahmen assoziiert.

Diskussion
Der Einsatz sedierender Medikamente als auch bewegungseinschränkender Maßnahmen variiert stark zwischen Interventions- und Kontrollgruppe. Andere Studien, die zu ähnlichen Ergebnissen kommen, sehen verschiedene Bausteine spezieller Versorgungskonzepte als Gründe für diese Unterschiede. Dazu zählen neben der baulichen Gestaltung und räumlichen Aspekten auch demenzspezifische Schulungsangebote und ein angemessener Personalschlüssel. Dies vermag auch Unruhe und herausfordernde Verhaltensweisen aufseiten der Patienten zu reduzieren. Der Verzicht auf Sedierung und bewegungseinschränkende Maßnahmen hat nicht zuletzt auch positive Auswirkungen auf die Lebensqualität von Menschen mit Demenz.
Alzheimer’s disease: targeting the glutamatergic system
Authors: Conway Myra E. 
Published: February 2020

AbstractAlzheimer’s disease (AD) is a debilitating neurodegenerative disease that causes a progressive decline in memory, language and problem solving. For decades mechanism-based therapies have primarily focused on amyloid β (Aβ) processing and pathways that govern neurofibrillary tangle generation. With the potential exception to Aducanumab, a monotherapy to target Aβ, clinical trials in these areas have been challenging and have failed to demonstrate efficacy. Currently, the prescribed therapies for AD are those that target the cholinesterase and glutamatergic systems that can moderately reduce cognitive decline, dependent on the individual. In the brain, over 40% of neuronal synapses are glutamatergic, where the glutamate level is tightly regulated through metabolite exchange in neuronal, astrocytic and endothelial cells. In AD brain, Aβ can interrupt effective glutamate uptake by astrocytes, which evokes a cascade of events that leads to neuronal swelling, destruction of membrane integrity and ultimately cell death. Much work has focussed on the post-synaptic response with little insight into how glutamate is regulated more broadly in the brain and the influence of anaplerotic pathways that finely tune these mechanisms. The role of blood branched chain amino acids (BCAA) in regulating neurotransmitter profiles under disease conditions also warrant discussion. Here, we review the importance of the branched chain aminotransferase proteins in regulating brain glutamate and the potential consequence of dysregulated metabolism in the context of BCAA or glutamate accumulation. We explore how the reported benefits of BCAA supplementation or restriction in improving cognitive function in other neurological diseases may have potential application in AD. Given that memantine, the glutamate receptor agonist, shows clinical relevance it is now timely to research related pathways, an understanding of which could identify novel approaches to treatment of AD.
Bivs, Space and ‘In’
Authors: Mac Cumhaill Clare 
Published: February 2020

AbstractI present a novel anti-sceptical BIV argument by focusing on conditions on the production and use of the locative preposition ‘in’. I distinguish two uses of ‘in’—material and descriptive phenomenological—and I explain in what respect movement is central to the concept that our use of ‘in’ expresses. I go on to argue that a functionalist semantics of the intelligible use of ‘in’ demands a materialist philosophy of action in the spirit of G.E.M. Anscombe, but also why the structure of space is not irrelevant either; appeal to the structure of space unsettles the causal-empirical assumptions that ground the picture of subjectivity and agency that the biv narrative assumes. Finally, I explain why a functionalist semantics demands a Naïve Realist metaphysics of perception, consistent with some of Putnam’s last writings on philosophy of perception.
Evaluation of wild barley introgression lines for agronomic traits related to nitrogen fertilization
Authors: Zahn Sarah , Koblenz Barbara , Christen Olaf , Pillen Klaus , Maurer Andreas 
Published: February 2020

AbstractIn the coming decades, climate change and resources constraints will make profitable and economically reliable agriculture more and more challenging. To evaluate the potential of exotic alleles to maintain performance under low nitrogen input, we investigated a set of 41 introgression lines (S42ILs) originating from the hybridization of the German spring barley ‘Scarlett’ and the Israeli wild barley ‘ISR42-8’. These lines were assessed in field trials for yield, yield components, grain protein content and chlorophyll content during growing seasons 2015 and 2016 in two different test sites in Germany under low and high nitrogen supply levels, N0 and N1. Our analyses revealed 17 regions for putative quantitative trait loci (QTL), linked to one or multiple traits, across all chromosomes. In particular, lines S42IL_119 and S42IL_121 exhibited an enhanced thousand grain weight of 7% and 9% under N1 and N0, respectively. In addition, six QTL were found for grain number per ear leading to a decline of grain number of up to 20%. Furthermore, three new QTL for chlorophyll content could be identified on chromosomes 1H and 2H. The present study revealed QTL effects of wild barley introgressions in a spring barley elite background, especially under low nitrogen. The selection for nitrogen efficient lines with beneficial exotic alleles represents the first step towards the development of spring barley cultivars genetically adapted to nitrogen limitations.
Supererogation and sequence
Authors: Bales Adam , Benn Claire 
Published: February 2020

AbstractMorally supererogatory acts are those that go above and beyond the call of duty. More specifically: they are acts that, on any individual occasion, are good to do and also both permissible to do and permissible to refrain from doing. We challenge the way in which discussions of supererogation typically consider our choices and actions in isolation. Instead we consider sequences of supererogatory acts and omissions and show that some such sequences are themselves problematic. This gives rise to the following puzzle: what problem can we have with a sequences of actions if each individual act or omission is itself permissible? In this paper, we develop a response to this question, by exploring whether solutions analogous to those proposed in the rational choice literature are available in the case of supererogatory sequences. Our investigation leads us to the view that making sense of the supererogatory requires accepting that there are global moral norms that apply to sequences of acts alongside the local moral norms that apply to individual acts.
Rapid Solidification Microstructure and Carbide Precipitation Behavior in Electron Beam Melted High-Speed Steel
Authors: Jin J. , Gao R. , Peng H. , Guo H. , Gong S. , Chen B. 
Published: February 2020

Abstract
The solidified microstructure and carbide precipitation behavior in an S390 high-speed steel processed by electron beam melting (EBM) have been fully characterized. The as-EBM microstructure consists of discontinuous network of very fine primary carbides dispersed in auto-tempered martensite matrix together with a limited amount of retained austenite. The carbide network consists of M2C/M6C and MC carbides. Both the columnar and near-equiaxed grain structures were found in as-EBM microstructure and the presence of inter-dendritic eutectic carbides assisted in revealing the dendritic solidification nature. The top-layer microstructure observation confirmed that the columnar dendritic structured grains were located adjacent to the micro-melt pool boundary, indicating an epitaxial growth with the average growth direction parallel to the maximum thermal gradient. At the center of the micro-melt pool, the near-equiaxed grains were developed by dendritic growth parallel to the beam traveling direction. The carbide decomposition was revealed by scanning transmission electron microscopy and confirmed by transmission Kikuchi diffraction. The MC carbides (rich in V followed by W) nucleated at the interface between M2C (W, Fe, Mo, and Co in the order of significance) and the matrix and then grew from the outside inward, but their nucleation might occur from the M2C carbide itself. The thermal effect induced by the adjacent scan lines seems to trigger a solid-state phase transformation of MC → M2C + γ-Fe. The elemental migration was theoretically calculated and compared with the experimental results. The high hardness of ~ 65 HRC and good transverse rupture strength of ~ 2500 MPa in as-EBM S390 means that EBM processing can be used to fabricate highly alloyed tool steels. With the help of the post-processing heat treatment, the best Rockwell hardness of 73.1±0.2 HRC and transverse rupture strength of 3012±34 MPa can be obtained.
Wat als prostaatkanker in de familie voorkomt?
Authors: Cremers Ruben G. H. M. , Blanker Marco H. , Bloemendal Maaike M. 
Published: February 2020

SamenvattingIn de algemene populatie geldt het advies om bij een verzoek om PSA-bepaling eerst de voors en tegens goed af te wegen, eventueel ondersteund door online tools, zoals te vinden zijn op https://www.thuisarts.nl/keuzehulpen/psa/. De familieanamnese is daarbij van belang voor het inschatten van een mogelijk erfelijk verhoogde kans op een agressieve prostaatkanker. Zowel het voorkomen als ook de mate van agressiviteit van de prostaatkankers dient daarbij uitgevraagd te worden, als ook tumoren die aan BRCA2-mutaties gerelateerd zijn (mammacarcinoom en ovariumcarcinoom bij vrouwelijke familieleden). Een (mogelijk) verhoogd erfelijk risico op agressieve prostaatkanker kan worden gebruikt om af te wijken van het algemene advies: bij eerstegraads verwanten van prostaatkankerpatiënten in HPC-families wordt tweejaarlijks PSA-onderzoek vanaf 50 jaar (of vanaf 5 jaar vóór de jongste prostaatkankerpatiënt in de familie) geadviseerd. Het vóórkomen van niet-agressieve prostaatkankers in de familie is biologisch gezien geen reden om af te wijken van het algemene advies ten aanzien van prostaatkankerscreening.
Case report: manic episode with psychotic symptoms induced by hyponatremia
Authors: Mauracher Laurin , Rettenbacher Maria 
Published: February 2020

SummaryIn the literature, several cases of an association between hyponatremia and psychotic symptoms have been reported. We present the case of a young Caucasian male presenting with rapid, incoherent speech, religious and megalomanic delusions, and emotional lability. The patient was described by his relatives as being healthy until a few days before admission. He had no significant medical or psychiatric history, except a short drug-induced psychotic episode a few years earlier. Somatic workup showed moderate hyponatremia, but no other abnormalities. Tests for narcotics, in particular, were also negative. Antipsychotic treatment with risperidone was initiated. After normalization of sodium levels using intravenous saline, the patient remitted within a few days and risperidone was discontinued on day 3. He was discharged by day 13 without further pharmacological treatment.Dysfunction of voltage-gated ion channels, particularly sodium and calcium channels, has been implicated in the pathogenesis of bipolar disorder. We therefore assume a causal relationship between hyponatremia and manic-psychotic symptoms in our patient. Hyponatremia was most likely induced by excessive water intake during a period of fasting in the context of a wellness practice.
Propeller influence on the aeroelastic stability of High Altitude Long Endurance aircraft
Authors: Teixeira P.C. , Cesnik C.E.S. 
Published: February 2020

AbstractThis work investigates the propeller’s influence on the stability of High Altitude Long Endurance aircraft, incorporating all resultant loads at the propeller hub, propeller slipstream, and gyroscopic loads. Such effects are usually neglected in the aeroelastic simulation of HALE aircraft. For that goal, a previously developed framework, which couples a geometrically nonlinear structural solver with an Unsteady Vortex Lattice method (uVLM) for lifting surfaces and a Viscous Vortex Particle (VVP) method for propeller slipstream, was employed to generate time-data series. Also, a method, based on a combination of Proper Orthogonal Decomposition and system identification, to extract dynamic information (frequencies, damping, and modes) of the aircraft from a time-series signal is proposed and successfully tested for a purely structural case, for which reference data is available. The method is then applied to investigate the stability of aeroelastic cases. The results demonstrate that the presence of propellers can influence the aeroelastic stability of a Very Flexible Aircraft.
THE EFFECTS OF FOREIGN LANGUAGE PROFICIENCY ON PUBLIC ATTITUDES: EVIDENCE FROM THE CHINESE-SPEAKING WORLD
Authors: Hu Yue , Liu Amy H. 
Published: February 2020

AbstractWhat explains public attitudes towards a former aggressor state? Conventional wisdom would suggest the prevalence of negative sentiments rooted in historical hatred. In this article we contend that when individuals are proficient in a foreign language—e.g. a lingua franca—they have an alternative channel through which they are exposed to positive narratives put forth by other parties regarding the former aggressor state. And as a result, their attitudes towards the former aggressor state are more positive than those held by their linguistically limited counterparts. To test our argument, we focus on public attitudes towards the Japanese in Mainland China, Singapore, and Taiwan—three Chinese-ethnic majority political units that experienced Japanese aggression leading up to and during World War II. Using survey data, we demonstrate that individuals who are proficient in the English language are much more likely to hold positive attitudes of the Japanese. These results are robust even when we consider whether some individuals are predisposed to being cosmopolitan; whether some individuals have more opportunities to learn English; and whether the linguistic effects are symptomatic of American soft power.
Dinocyst stratigraphy of the Valanginian–Aptian Rurikfjellet and Helvetiafjellet formations on Spitsbergen, Arctic Norway
Authors: Śliwińska Kasia K. , Jelby Mads E. , Grundvåg Sten-Andreas , Nøhr-Hansen Henrik , Alsen Peter , Olaussen Snorre 
Published: February 2020

AbstractIn order to improve the understanding of how the high northern latitudes responded to the escalating warming which led to the middle Cretaceous super greenhouse climate, more temperature proxy records from the High Arctic are needed. One of the current obstacles in obtaining such records is poor age control on the Lower Cretaceous strata in the Boreal region. Here, we provide a biostratigraphic framework for the Rurikfjellet and Helvetiafjellet formations representing the lower part of the Lower Cretaceous succession on Spitsbergen. We also attempt to date the boundary between the Agardhfjellet and the Rurikfjellet formations. This study is based on dinoflagellate cysts (dinocysts) from three onshore cores (DH1, DH2 and DH5R) and three outcrop sections (Bohemanflya, Myklegardfjellet and Ullaberget). Relatively abundant and well-preserved dinocyst assemblages from the Rurikfjellet Formation date this unit as early Valanginian – early Barremian. The dinocyst assemblages from the Helvetiafjellet Formation are significantly impoverished and are characterized by reworking, but collectively indicate a Barremian–Aptian age for this formation.
De novoprotein design, a retrospective
Authors: Korendovych Ivan V. , DeGrado William F. 
Published: February 2020

AbstractProteins are molecular machines whose function depends on their ability to achieve complex folds with precisely defined structural and dynamic properties. The rational design of proteins from first-principles, orde novo, was once considered to be impossible, but today proteins with a variety of folds and functions have been realized. We review the evolution of the field from its earliest days, placing particular emphasis on how this endeavor has illuminated our understanding of the principles underlying the folding and function of natural proteins, and is informing the design of macromolecules with unprecedented structures and properties. An initial set of milestones inde novoprotein design focused on the construction of sequences that folded in water and membranes to adopt folded conformations. The first proteins were designed from first-principles using very simple physical models. As computers became more powerful, the use of the rotamer approximation allowed one to discover amino acid sequences that stabilize the desired fold. As the crystallographic database of protein structures expanded in subsequent years, it became possible to construct proteins by assembling short backbone fragments that frequently recur in Nature. The second set of milestones inde novodesign involves the discovery of complex functions. Proteins have been designed to bind a variety of metals, porphyrins, and other cofactors. The design of proteins that catalyze hydrolysis and oxygen-dependent reactions has progressed significantly. However,de novodesign of catalysts for energetically demanding reactions, or even proteins that bind with high affinity and specificity to highly functionalized complex polar molecules remains an importnant challenge that is now being achieved. Finally, the protein design contributed significantly to our understanding of membrane protein folding and transport of ions across membranes. The area of membrane protein design, or more generally of biomimetic polymers that function in mixed or non-aqueous environments, is now becoming increasingly possible.
Habitual versus affective motivations in obsessive-compulsive disorder and alcohol use disorder
Authors: Ferreira Gabriela M. , Lee Rico S.C. , Piquet-Pessôa Marcelo , de Menezes Gabriela B. , Moreira-de-Oliveira Maria E. , Albertella Lucy , Yücel Murat , dos Santos Cruz Marcelo , dos Santos-Ribeiro Samara , Fontenelle Leonardo F. 
Published: February 2020

AbstractObjectiveTo (1) confirm whether the Habit, Reward, and Fear Scale is able to generate a 3-factor solution in a population of obsessive-compulsive disorder and alcohol use disorder (AUD) patients; (2) compare these clinical groups in their habit, reward, and fear motivations; and (3) investigate whether homogenous subgroups can be identified to resolve heterogeneity within and across disorders based on the motivations driving ritualistic and drinking behaviors.MethodsOne hundred and thirty-four obsessive-compulsive disorder (n = 76) or AUD (n = 58) patients were assessed with a battery of scales including the Habit, Reward, and Fear Scale, the Yale-Brown Obsessive-Compulsive Scale, the Alcohol Dependence Scale, the Behavioral Inhibition/Activation System Scale, and the Urgency, (lack of
) Premeditation, (lack of
) Perseverance, Sensation Seeking, and Positive Urgency Impulsive Behavior Scale.ResultsA 3-factor solution reflecting habit, reward, and fear subscores explained 56.6% of the total variance of the Habit, Reward, and Fear Scale. Although the habit and fear subscores were significantly higher in obsessive-compulsive disorder (OCD) and the reward subscores were significantly greater in AUD patients, a cluster analysis identified that the 3 clusters were each characterized by differing proportions of OCD and AUD patients.ConclusionsWhile affective (reward- and fear-driven) and nonaffective (habitual) motivations for repetitive behaviors seem dissociable from each other, it is possible to identify subgroups in a transdiagnostic manner based on motivations that do not match perfectly motivations that usually described in OCD and AUD patients.
Devout Neoliberalism?! Explaining Egypt's Muslim Brotherhood's Socio-economic Perspective and Policies
Authors: al-Anani Khalil 
Published: February 2020

AbstractHow can we explain the neoliberal orientation of Islamist movements in the Middle East? This paper attempts to answer this question by exploring the case of the Muslim Brotherhood in Egypt. It analyzes in depth the Brotherhood's socio-economic vision and policies when it was in power between 2012 and 2013. It argues that the Brotherhood adopted a market-oriented vision, which encouraged the private sector, liberalized the economy, and appealed to foreign investments. As a socio-political movement, the Brotherhood attempted to strike a balance between its constituency, which is rooted in the lower, middle, and upper-middle classes, and its commitment to neoliberal policies. However, this paradoxical balance burdened the movement and affected its popularity. The article also contends that the Brotherhood's neoliberal leanings can be explained by three key factors: the movement's pragmatism, its “devout” bourgeoisie, and the appeal for international acceptance and recognition.
The Project Talent Twin and Sibling Study: Zygosity and New Data Collection
Authors: Prescott Carol A. , Walters Ellen E. , Arpawong Thalida Em , Zavala Catalina , Gruenewald Tara L. , Gatz Margaret 
Published: February 2020

AbstractThe Project Talent Twin and Sibling (PTTS) study includes 4481 multiples and their 522 nontwin siblings from 2233 families. The sample was drawn from Project Talent, a U.S. national longitudinal study of 377,000 individuals born 1942–1946, first assessed in 1960 and representative of U.S. students in secondary school (Grades 9–12). In addition to the twins and triplets, the 1960 dataset includes 84,000 siblings from 40,000 other families. This design is both genetically informative and unique in facilitating separation of the ‘common’ environment into three sources of variation: shared by all siblings within a family, specific to twin-pairs, and associated with school/community-level factors. We term this the GIFTS model for genetics, individual, family, twin, and school sources of variance. In our article published in a previous Twin Research and Human Genetics special issue, we described data collections conducted with the full Project Talent sample during 1960–1974, methods for the recent linking of siblings within families, identification of twins, and the design of a 54-year follow-up of the PTTS sample, when participants were 68–72 years old. In the current article, we summarize participation and data available from this 2014 collection, describe our method for assigning zygosity using survey responses and yearbook photographs, illustrate the GIFTS model applied to 1960 vocabulary scores from more than 80,000 adolescent twins, siblings and schoolmates and summarize the next wave of PTTS data collection being conducted as part of the larger Project Talent Aging Study.