bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Overlapping Uncertainties of Film Professionals
Authors: Moghaddari Sonja 
Published: December 2019

AbstractReturning to an interpersonal micro-perspective, this chapter centers on the development of ties between the three film professionals Hushang, Kian, and Milad and examines the way they try to generate capital in German and Iranian local and transnational professional social fields. Building on previous research on social capital and the film business, the analysis brings the difficulties of interdependence in internal relations to the forefront. Furthermore, I highlight how systems of value prevailing in different social fields may both intersect and overlap, thus accounting for the fact that agency in different social fields is interconnected. The ways the three men deal with uncertainties deriving from migration and the job market illustrates that people with similar resources may still find very different ways of dealing with barriers to inclusion.
The Prevention of Chronic Diseases Through eHealth: A Practical Overview
Authors: Monzani Dario , Pizzoli Silvia Francesca Maria 
Published: November 2019

AbstractDisease prevention is an umbrella term embracing individual-based or population-based interventions aimed at preventing the manifestation of diseases (primary prevention), reducing the impact of a disease that has arisen (secondary prevention), or mitigating the impact of an ongoing illness (tertiary prevention). Digital health has the potential to improve prevention of chronic diseases. Its application ranges from effective mHealth weight-loss intervention to prevent or delay the onset of diabetes in overweight adults to the cost-effective intervention on the provision of mental-health care via mobile-based or Internet-based programs to reduce the incidence or the severity of anxiety. The present contribution focuses on the effectiveness of eHealth preventive interventions and on the role of digital health in improving health promotion and disease prevention. We also give a practical overview on how eHealth interventions have been effectively implemented, developed, and delivered for the primary, secondary, and tertiary prevention of chronic diseases.
Introduction
Authors: Jarmai Katharina 
Published: December 2019

AbstractThe concept of Responsible Research and Innovation (RRI) originates in discourses on emerging technologies and research ethics in contested innovative fields, such as nanotechnologies or geo-engineering, and has been predominantly driven by European research and innovation policy over the past 10 years. The concept was initially developed and introduced by policy makers and social scientists, but recent studies have aimed to shed light on the implementation of responsible research and innovation practices in business. The contributions collected in this book are a result of work conducted by seven partner organisations in the European funded Horizon 2020 project “COMPASS – Evidence and opportunities for responsible innovation in SMEs”. In combination, they illustrate that responsible innovation (RI) has been emerging as a new field in the ongoing discourse on the role and responsibility of business in society.
Learning from Sustainability-Oriented Innovation
Authors: Jarmai Katharina 
Published: December 2019

AbstractThis chapter argues that insights from the realm of sustainability-oriented innovation can provide useful answers to the question of why Small and Medium-Sized Enterprises (SMEs) would (or should) become interested in implementing responsible innovation practices. It is based on the assumption that “responsible innovation” and “sustainability-oriented innovation” are different approaches aimed at orienting innovation towards increased positive impacts on social and natural environments. Motivations and influences for pursuing sustainability-oriented innovation have been studied in the past, and can provide insights into reasons for pursuing the implementation of responsible innovation practices.
Parent personality is linked to juvenile mortality and stress behavior in the arctic fox (Vulpes lagopus)
Authors: Choi Seoyun , Grocutt Emma , Erlandsson Rasmus , Angerbjörn Anders 
Published: December 2019

AbstractLife history theory predicts that individuals will differ in their risk-taking behavior according to their expected future fitness. Understanding consequences of such individual variation within a behavioral trait is crucial in explaining potential trade-offs between different traits and in predicting future dynamics in changing environments. Here, we studied individuals in a wild arctic fox population to explore if (1) individual variation in risk-taking behaviors of adult arctic foxes and in stress-dealing behaviors of their juveniles exist and are consistent over time to verify the existence of personality traits; (2) those behavioral traits in adults and juveniles are correlated; (3) they can explain fitness-related components (i.e., juvenile physical condition, mortality rate). We presented simple field experiments assessing behavioral traits by observing adult reactions toward approaching observers, and juvenile behaviors while trapping. Through the experiments, we found highly consistent individual variation of adults in vigilance and boldness levels, and more flexible juvenile behavioral traits categorized as investigating, passive, and escaping. The offspring of bolder adults exhibited more investigating behaviors and were less passive than the offspring of shy adults. Juvenile physical condition was not related to their mortality nor any behavioral traits of either parents or themselves. Lastly, highly investigating and active juveniles with bold parents had significantly lower mortality rates. This shows that interactions between parent personality and juvenile behavioral traits affect a fitness-related component in the life history of individuals.Significance statementThe recent surge of interest in consistent individual difference in behavior, also called as animal personality, has already focused on its fitness consequences, but few studies have investigated the interactions between parent and offspring personality, and their ecological consequences. Moreover, this has rarely been studied in wild canids. The arctic fox is a charismatic species showing wide individual variation in behaviors. They live in highly fluctuating tundra ecosystems providing different selection regimes, making it even more eco-evolutionarily intriguing. Yet, few studies looked into behavioral traits and their importance in this system. While introducing simple methods to improve personality research in the wild, we provide a unique example of how variation in both parents and their juveniles collectively works for group dynamics in a cyclic population. This provides a firm basic for understanding behavior-mediated dynamics and opens up broader questions on how fluctuating environments exert varying pressures on individual differences.
Proposal for a National Blueprint Framework to Monitor Progress on Water-Related Sustainable Development Goals in Europe
Authors: Essex B. , Koop S. H. A. , Van Leeuwen C. J. 
Published: December 2019

AbstractThe 17 Sustainable Development Goals (SDGs) underpinned by 169 targets presents national governments with huge challenges for implementation. We developed a proposal for a National Blueprint Framework (NBF) with 24 water-related indicators, centered on SDG 6 (clean water and sanitation for all), each with a specific target. We applied the NBF to 28 EU Member States (EU-28) and conclude that:

The current SDG 6 indicators are useful for monitoring progress toward water-related targets but their usefulness can be improved by focusing more on their practical implementation.

The extension of SDG 6 with complementary indicators (e.g. for the circular economy of water) and quantitative policy targets is urgently needed. This will benefit the communication process and progress at the science-policy interface.

SDG indicators can be improved in a SMART (specific, measurable, achievable, relevant, and time-bound) manner and by setting clear policy targets for each indicator, allowing for measuring distance-to-targets. This allows country-to-country comparison and learning, and accelerates the SDG implementation process.

We propose 24 water-related indicators centered on SDG 6, with complementary indicators including quantitative policy targets. The approach is doable, easily scalable, and flexibly deployable by collecting information for the EU-28.

Main gaps in the EU-28 are observed for water quality, wastewater treatment, nutrient, and energy recovery, as well as climate adaptation to extreme weather events (heat, droughts, and floods).

The framework was less successful for non-OECD countries due to lack of data and EU-centric targets for each indicator. This needs further research.
Impact of the Kaiser score on clinical decision-making in BI-RADS 4 mammographic calcifications examined with breast MRI
Authors: Wengert G. J. , Pipan F. , Almohanna J. , Bickel H. , Polanec S. , Kapetas P. , Clauser P. , Pinker K. , Helbich T. H. , Baltzer P. A. T. 
Published: December 2019

Abstract
Objectives
To investigate whether the application of the Kaiser score for breast magnetic resonance imaging (MRI) might downgrade breast lesions that present as mammographic calcifications and avoid unnecessary breast biopsies

Methods
This IRB-approved, retrospective, cross-sectional, single-center study included 167 consecutive patients with suspicious mammographic calcifications and histopathologically verified results. These patients underwent a pre-interventional breast MRI exam for further diagnostic assessment before vacuum-assisted stereotactic-guided biopsy (95 malignant and 72 benign lesions). Two breast radiologists with different levels of experience independently read all examinations using the Kaiser score, a machine learning–derived clinical decision-making tool that provides probabilities of malignancy by a formalized combination of diagnostic criteria. Diagnostic performance was assessed by receiver operating characteristics (ROC) analysis and inter-reader agreement by the calculation of Cohen’s kappa coefficients.

Results
Application of the Kaiser score revealed a large area under the ROC curve (0.859–0.889). Rule-out criteria, with high sensitivity, were applied to mass and non-mass lesions alike. The rate of potentially avoidable breast biopsies ranged between 58.3 and 65.3%, with the lowest rate observed with the least experienced reader.

Conclusions
Applying the Kaiser score to breast MRI allows stratifying the risk of breast cancer in lesions that present as suspicious calcifications on mammography and may thus avoid unnecessary breast biopsies.

Key Points
• The Kaiser score is a helpful clinical decision tool for distinguishing malignant from benign breast lesions that present as calcifications on mammography.
• Application of the Kaiser score may obviate 58.3–65.3% of unnecessary stereotactic biopsies of suspicious calcifications.
• High Kaiser scores predict breast cancer with high specificity, aiding clinical decision-making with regard to re-biopsy in case of negative results.
Avoiding skull radiographs in infants with suspected inflicted injury who also undergo head CT: “a no-brainer?”
Authors: Martin Andrew , Paddock Michael , Johns Christopher S. , Smith Jessica , Raghavan Ashok , Connolly Daniel J. A. , Offiah Amaka C. 
Published: December 2019

Abstract
Objectives
To assess whether head CT with 3D reconstruction can replace skull radiographs (SXR) in the imaging investigation of suspected physical abuse (SPA)/abusive head trauma (AHT).

Methods
PACS was interrogated for antemortem skeletal surveys performed for SPA, patients younger than 2 years, SXR and CT performed within 4 days of each other. Paired SXR and CT were independently reviewed. One reviewer analysed CT without and (3 months later) with 3D reconstructions. SXR and CT expert consensus review formed the gold standard. Observer reliability was calculated.

Results
A total of 104 SXR/CT examination pairs were identified, mean age 6.75 months (range 4 days to 2 years); 21 (20%) had skull fractures; two fractures on CT were missed on SXR. There were no fractures on SXR that were not seen on CT. For SXR and CT, respectively: PPV reviewer 1, 95% confidence interval (CI) 48–82% and 85–100%; reviewer 2, 67–98% and 82–100%; and NPV reviewer 1, 95%, CI 88–98% and 96–100%; reviewer 2, 88–97% and 88–98%. Inter- and intra-observer reliability were respectively the following: SXR, excellent (kappa = 0.831) and good (kappa = 0.694); CT, excellent (kappa = 0.831) and perfect (kappa = 1). All results were statistically significant (p < 0.001).

Conclusions
CT has greater diagnostic accuracy than SXR in detecting skull fractures which is increased on concurrent review of 3D reconstructions and should be performed in every case of SPA/AHT. SXR does not add further diagnostic information and can be omitted from the skeletal survey when CT with 3D reconstruction is going to be, or has been, performed.

Key Points
• Head CT with 3D reconstruction is more sensitive and specific for the diagnosis of skull fractures.
• Skull radiographs can be safely omitted from the initial skeletal survey performed for suspected physical abuse when head CT with 3D reconstruction is going to be, or has been, performed.
Fluid moment and force measurement based on control surface integration
Authors: Chin Diana D. , Lentink David 
Published: December 2019

AbstractThe moments and torques acting on a deforming body determine its stability and maneuverability. For animals, robots, vehicles, and other deforming objects locomoting in liquid or gaseous fluids, these fluid moments are challenging to accurately measure during unconstrained motion. Particle image velocimetry and aerodynamic force platforms have the potential to resolve this challenge through the use of control surface integration. These measurement techniques have previously been used to recover fluid forces. Here, we show how control surface integration can similarly be used to recover the 3D fluid moments generated about a deforming body’s center of mass. We first derive a general formulation that can be applied to any body locomoting in a fluid. We then show when and how this formulation can be greatly simplified without loss of accuracy for conditions commonly encountered during fluid experiments, such as for tests done in wind or water channels. Finally, we provide detailed formulations to show how measurements from an aerodynamic force platform can be used to determine the net instantaneous moments generated by a freely flying body. These formulations also apply more generally to other fluid applications, such as underwater swimming or locomotion over water surfaces.Graphic abstract
Flow around an oscillating grid in water and shear-thinning polymer solution at low Reynolds number
Authors: Lacassagne Tom , Lyon Adrien , Simoëns Serge , Hajem Mahmoud El , Champagne Jean-Yves 
Published: December 2019

AbstractThe study of turbulence in complex fluids is of great interest in many environmental and industrial applications, in which the interactions between liquid phase rheology, turbulence, and other phenomena such as mixing or heat and mass transfer have to be understood. Oscillating grid stirred tanks have been used for many purposes in research involving turbulence. However, the mechanisms of turbulence production by the oscillating grid itself have never been studied, and oscillating grid turbulence (OGT) remained undescribed in non-Newtonian, shear-thinning, dilute polymer solutions until recently (Lacassagne et al., in Phys Fluids 31(8):083,102, 2019). The aim of this paper is to study the influence of the shear-thinning property of dilute polymer solutions (DPS), such as xanthan gum (XG), on mean flow, oscillatory flows, and turbulence around an oscillating grid. Liquid phase velocity is measured by particle image velocimetry (PIV) in a vertical plane above the central grid bar. Mean, oscillatory and turbulent components of the velocity fields are deduced by triple Hussain–Reynolds decomposition based on grid phase-resolved measurements. Outside of the grid swept region, the amplitude of oscillatory fluctuations quickly become negligible compared to that of turbulent fluctuations, and the triple and classical Reynolds decomposition become equivalent. Oscillatory jets and wakes behind the grid and their interactions are visualized. Turbulent (Reynolds) and oscillatory stresses are used to evidence a modification of oscillatory flow and turbulence intensity repartition in and around the grid swept region. Energy transfer terms between mean, oscillatory and turbulent flows are estimated and used to describe turbulence production in the grid swept region. Energy is injected by the grid into the oscillatory component. In water, it is transferred to turbulence mostly inside the grid swept region. In DPS, oscillatory flow persists outside of the grid swept zone. Energy is transferred not only to turbulence , in the grid swept region, and far from the tank’s walls, but also to the mean flow, leading to an enhancement of the latter. Mean flow production and enhancement mechanisms are explainable by oscillatory jet variable symmetry and intensity, and by time- and space-variable viscosity. Backward transfer from turbulence to oscillatory flow is also evidenced in DPS. Finally, using phased root mean square (rms) values of turbulent velocity fluctuations, it is shown that in water, the decay of turbulence intensity behind an oscillating grid can be related to the decay of fixed grid turbulence for specific grid positions, a result no longer valid in DPS.Graphic abstract
Deep neck space infections: an upward trend and changing characteristics
Authors: Velhonoja Jarno , Lääveri Meira , Soukka Tero , Irjala Heikki , Kinnunen Ilpo 
Published: December 2019

Abstract
Purpose
This study reviews our experience with deep neck space infections (DNIs) requiring surgical intervention, including cervical necrotizing fasciitis. The aim of the study was to identify predisposing and aggravating factors of the disease and recognize the possible factors that can lead to life-threatening complications and slow down the healing process.

Methods
We compare the results to previous data from 1985 to 2005 to find possible alterations and changing trends. The characteristics of four lethal cases are described. This retrospective analysis includes patient data from 2004 to 2015 in tertiary referral hospital and in total, 277 patients were found.

Results
Surgical drainage through a neck opening ± intraoral incision was made in 215 (77.6%) patients, an intraoral incision was only made in 62 patients (22.4%). ICU care was needed in 66 (23.8%) cases. Odontogenic etiology (44.8%) was the most common origin. The most common comorbidity was a psychiatric disorder and/or dementia and occurred in 55 (19.9%) patients. Patients with underlying illnesses were more likely to be admitted to the ICU (p = 0.020), required a longer ICU stay (p = 0.004) and repeated surgery (p = 0.009). Gas formation seemed to be predictive of a more severe course of infection. Early extraction of the odontogenic foci was related to a lower length of stay (LOS) (p = 0.039).

Conclusion
The annual numbers have risen from 14 to 24 cases per year when compared to previous data. DNIs remain a cause of lethal complications; the mortality was 1.4% and overall complications occurred in 61 (22.0%) patients.
Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria
Authors: Vaca Diana J. , Thibau Arno , Schütz Monika , Kraiczy Peter , Happonen Lotta , Malmström Johan , Kempf Volkhard A. J. 
Published: November 2019

AbstractThe capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by “anti-ligands” to prevent colonization or infection of the host. Future development of such “anti-ligands” (specifically interfering with bacteria-host matrix interactions) might result in the development of a new class of anti-infective drugs for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. This review summarizes our current knowledge about the manifold interactions of adhesins expressed by Gram-negative bacteria with ECM proteins and the use of this information for the generation of novel therapeutic antivirulence strategies.
Prediction of renal outcome in Henoch–Schönlein nephritis based on biopsy findings
Authors: Koskela Mikael , Ylinen Elisa , Autio-Harmainen Helena , Tokola Heikki , Heikkilä Päivi , Lohi Jouko , Jalanko Hannu , Nuutinen Matti , Jahnukainen Timo 
Published: December 2019

Abstract
Background
In Henoch–Schönlein nephritis (HSN), a risk factor for unfavorable outcome is prolonged proteinuria, but the value of renal biopsies in prognosis assessment is debatable.

Methods
We evaluated serial renal biopsies from 26 HSN patients. Follow-up biopsy occurred at median 2.1 years after diagnostic biopsy. Patients formed two groups at the follow-up biopsy: patients without proteinuria (group I; n = 11) and with proteinuria (group II; n = 15). Biopsies underwent evaluation according to three classifications: International Study of Kidney Disease in Children (ISKDC), Oxford (MEST-C), and semiquantitative classification (SQC) including an activity and chronicity score. Analysis also included expression of pro-fibrotic (alpha-smooth muscle actin and vimentin) and inflammatory (P-selectin glycoprotein ligand-1) molecules in the diagnostic biopsy specimens. Definition of unfavorable outcome was active renal disease or reduced renal function at last follow-up.

Results
Between the biopsies, SQC chronicity score increased in 22 (85%) patients, whereas activity score and ISKDC grade decreased in 21 (81%) and 17 (65%), respectively. Of the MEST-C parameters, endocapillary proliferation (from 83 to 13%; p < 0.001) and crescents (from 63 to 25%; p = 0.022) showed significant reduction, and segmental glomerulosclerosis (from 38 to 79%; p = 0.006) significant increment. These changes occurred similarly in groups I and II. Expression of the pro-fibrotic and inflammatory molecules showed no clinically significant differences between groups I and II. None in group I and five (33%) patients in group II had unfavorable outcome (p = 0.053).

Conclusions
Our results suggest that follow-up biopsies provide limited additional information to clinical symptoms in HSN outcome prediction.