bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD38 is associated with communal behavior, partner perceptions, affect and relationship adjustment in romantic relationships
Authors: Sadikaj Gentiana , Moskowitz D. S. , Zuroff David C. , Bartz Jennifer A. 
Published: August 2020

AbstractGiven the significance of close relationships for human survival, it is thought that biological mechanisms evolved to support their initiation and maintenance. The neuropeptide oxytocin is one such candidate identified in non-human animal research. We investigated whether variation in CD38, a gene involved in oxytocin secretion and attachment behavior in rodents, predicts romantic relationship dynamics in daily life. Community couples participated in an event-contingent recording (ECR) study in which they reported their social behavior, perception of their partner’s behavior, and affect during their interactions with one another over a 20-day period; couples also completed various measures of relationship adjustment. Out of the 111 couples (N = 222 individuals) who provided either ECR and/or relationship adjustment information, we had information on CD38 for 118 individuals. As hypothesized, variation in rs3796863, a single nucleotide polymorphism (SNP) identified in prior work, predicted communal behaviors (e.g., the expression of affection), as well as overall relationship adjustment, such that individuals with the CC (vs. AC/AA) allele reported higher levels of communal behavior across their daily interactions with their romantic partner, as well as higher levels of relationship adjustment. Individuals with the CC (vs. AC/AA) allele of rs3796863 also reported less negative affect and felt insecurity in their interactions with their romantic partner. Notably, we found that variation in the romantic partner's rs3796863 SNP was related to the person's outcomes, independent of the person’s rs3796863 genotype. These findings support the role of oxytocin in the interpersonal processes implicated in the maintenance of close relationships.
Serum creatinine/cystatin C ratio as a case-finding tool for low handgrip strength in Chinese middle-aged and older adults
Authors: Tan Lingling , Li Ruicen , Hu Xiaoyi , Zhu Yuan , Bao Ting , Zuo Yun , Yang Ming 
Published: August 2020

AbstractMeasuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Trained nurses collected blood samples and conducted the anthropometric measurements and handgrip strength test. The serum concentrations of Cr, CysC, and other biomarkers were measured. We recruited 1098 men and 1241 women. The Cr/CysC ratio was significantly associated with AWGS-defined low handgrip strength among men and women. The areas under the receiver operating characteristic curves were 0.79 among men and 0.78 among women for using the Cr/CysC ratio to identify AWGS-defined low handgrip strength. We set the Cr/CysC ratio cut-off values at < 8.9 among men and < 8.0 among women. The corresponding sensitivity values were 64.9% among men and 63.1% among women, while the specificity values were 83.7% among men and 77.5% among women. In conclusion, the Cr/CysC ratio is positively and linearly associated with handgrip strength and may be helpful for screening low handgrip strength in Chinese middle-aged and older adults dwelling in communities.
Die Klinik und Poliklinik für Dermatologie und Venerologie der Universitätsmedizin Rostock – von Fischschuppenerkrankungen, Mondscheinkindern und viel, viel Mee(h)r!
Authors: Emmert S. , Panzer R. , Rode S. , Thiem A. , Tietze J. , Blaschke V. , Fischer T. , Böckmann L. 
Published: August 2020

ZusammenfassungDie Universität Rostock und die Universitätsmedizin als Gründungsfakultät ist die drittälteste Alma Mater in Mitteleuropa – 2019 hat sie ihr 600-jähriges Bestehen gefeiert. Die Klinik und Poliklinik für Dermatologie und Venerologie der Universitätsmedizin Rostock kann auf eine ähnlich lange Tradition zurückblicken – sie ist das drittälteste Ordinariat nach Breslau und der Charité in Berlin. Gemäß dem universitären Motto „Traditio et Innovatio“ hat sich aus dieser Tradition, begründet durch angesehene Ordinarien wie Wolters, Frieboes oder auch Flegel zu DDR-Zeiten, in den letzten 4 Jahren eine moderne universitäre Dermatologische Universitätsklinik (DUK) mit hoher Entwicklungsdynamik und einem Masterplan DUK2030 für alle Bereiche der Krankenversorgung, Forschung und Lehre entwickelt. Unter einem Dach sind stationäre, teilstationäre, ambulante und operative Patientenversorgung zusammen mit dem histologischen und klinischen Labor und den Forschungslaboren vereint. Unter anderem durch Zentrumsgründungen vor Ort (Hautkrebszentrum, Immuntherapiezentrum, Allergologisches Zentrum, Gefäß- und Wundzentrum, Zentrum für Seltene (Haut-) Erkrankungen) und auf europäischer Ebene (Europäisches Referenznetzwerkzentrum für seltene Hauterkrankungen) hat diese interdisziplinäre Zusammenarbeit die Klinik lokal und überregional sehr gut vernetzt. Ein junges, hochengagiertes und noch expandierendes Team hat diese bisherige Entwicklung ermöglicht. Dafür kann allen Beteiligten nicht genug gedankt werden. Dieser und die folgenden Artikel geben einen Einblick in die dermatologische Welt der Universitätsmedizin Rostock.
Aquagener Pruritus als Warnzeichen eines inneren Tumorleidens – eine Fallvorstellung und Literaturübersicht
Authors: Troitzsch P. , Panzer R. , Emmert S. , Thiem A. 
Published: August 2020

ZusammenfassungAquagener Pruritus (AP), d. h. Jucken, Kribbeln, Brennen nach Wasserkontakt, ist ein häufiges Symptom bei Polycythaemia vera und anderen myeloproliferativen Neoplasien, kann aber auch unabhängig davon auftreten. Wie andere Formen des Pruritus schränkt AP die Lebensqualität der Betroffenen häufig ein und kann zu einem hohen Leidensdruck führen. Zur Pathogenese existieren unterschiedliche Erklärungsansätze, jedoch kein einheitliches Konzept. Passend dazu sprechen Patienten auch nur zum Teil auf vorhandene Therapien an, die überwiegend off label sind. In dieser Literaturübersicht zum AP werden beschriebene Pathomechanismen diskutiert und mögliche Therapieformen genannt. Ein verbessertes Verständnis von AP soll dazu beitragen, dieses Symptom zu erkennen und an mögliche zugrunde liegende Erkrankungen, insbesondere an ein inneres Tumorleiden, zu denken.
Differential Diagnosis of Acquired Esotropia in the Elderly
Authors: Roggenkämper Bettina , Neugebauer Antje , Fricke Julia , Hedergott Andrea M. 
Published: August 2020

AbstractAim To provide an overview of the differential diagnoses of acquired esotropia that occur in the elderly and to facilitate their differentiation in everyday clinical practice.Methods The data of all patients who presented in our outpatient university department for strabology and neuroophthalmology from March 2014 to October 2015 due to esotropia with diplopia with onset after age 50 were evaluated retrospectively. Exclusion criteria were a known strabismus before the age of 50 and/or vertical deviations in the primary position. Anamnestic characteristics, accompanying findings and orthoptic parameters, were analysed.Results 85 patients were included in the study, 42 of them female and 43 male. The following diagnoses were made: abducens nerve palsy (n = 34, 3 of them both sides), esotropia due to myopia magna (n = 12), esotropia with accompanying neurological symptoms (n = 6) and other etiology (n = 5). In 4 cases, the diagnosis was still unclear at the end of the study. In 24 patients, none of the above diagnoses existed and the diagnosis of “sagging eye syndrome” (ETSAG) was made. The abducens nerve palsy typically showed a sudden onset of double vision, slowed abduction saccades and asymmetrical abduction ability. With unilateral abducens nerve palsy, the esotropia increased continuously from the view to the unaffected side through the primary position to the view to the affected side. Patients with ETSAG and myopia-associated esotropia, on the other hand, reported a gradual onset of double vision, showed normal abduction saccades and a slightly reduced abduction ability. The squint angle often increased slightly to both sides. Esotropia with accompanying neurological symptoms was rare and was seen in various underlying diseases.Conclusions The kind of onset of the double vision, the quality of the saccades, the incomitance pattern and the ability to abduct are important parameters for the etiological assignment of an esotropia in the elderly. The characteristics of the individual diagnoses are described and differential diagnostic aspects are discussed.
Chondrokalzinose
Authors: Niemeier Andreas , Rüther Wolfgang 
Published: August 2020

ZUSAMMENFASSUNGAls Chondrokalzinose bezeichnet man die Ablagerung von Kalziumphosphaten im chondralen Gewebe. Im Gelenk treten die Minerale sowohl im hyalinen Knorpel wie im Faserknorpel auf. Die Kalzifikationen sind teils amorph, teils kristallin. Es werden sowohl apatitische Kristalle wie Pyrophosphatkristalle beobachtet. Die Ätiologie ist unklar, möglicherweise nicht monokausal. Es mehren sich die Hinweise, dass es sich um ein systemisches Geschehen, d. h. alle Gelenke betreffend, handelt, das – in geringerer Ausprägung – schon in jungem Alter einsetzt. Die Chondrokalzinose lässt sich so nicht als Sekundärphänomen einer Arthrose verstehen. Die Chondrokalzinose ist wahrscheinlich viel häufiger als sie diagnostiziert wird. Im Röntgenbild ist die Kalzinose erst dann erkennbar, wenn stärkere Depositionen vorliegen und wenn sich die Knorpelgewebe ohne Knochenüberlagerung projizieren lassen. Apatitische Kristalle sind derart klein, dass sie weder im Punktat noch im histologischen Schnitt lichtmikroskopisch erkennbar sind. Das Serumlabor ist unergiebig.
Medien und frühe Kindheitsentwicklung
Authors: Mall Volker 
Published: August 2020

ZUSAMMENFASSUNGDer Einsatz elektronischer Medien in der frühen Kindheit wird häufig kontrovers diskutiert. Der folgende Artikel soll zu dieser Diskussion einen evidenzbasierten Beitrag leisten. Mit dem Ziel konkrete Empfehlungen zur Mediennutzung abzugeben, wird vor allem zwei Fragen nachgegangen: 1. Die Auswirkungen von Mediennutzung in den ersten Lebensjahren auf die Entwicklung und die psychische Gesundheit. 2. Inwiefern „Lernen“ durch moderne elektronische Medien in dieser frühen Entwicklungsphase möglich ist. Die Literaturrecherche ergibt ein klares Bild bezüglich der Auswirkungen von exzessivem Medienkonsum auf die Kindesentwicklung und die psychische Gesundheit. Studien belegen eine verzögerte Sprachentwicklung, verzögerte motorische Fähigkeiten und Erhöhung des Risikos für Aufmerksamkeits- und Angststörung sowie Depression. Für Lerneffekte über digitale Medien gibt es zumindest vor dem 18. Lebensmonat keine Hinweise. Vor diesem Hintergrund wird der frühe Medienkonsum international einheitlich von allen Kinderärzte-Verbänden kritisch gesehen und ein Null-Konsum unter 18 (USA) bzw. 36 (D) Monaten empfohlen.
Patient Reported Outcomes
Authors: Deimel Hubertus , Chermette Chloé 
Published: August 2020

ZusammenfassungBewegungs- und sporttherapeutische Maßnahmen bilden einen festen Therapiebestandteil im Rahmen der multidisziplinären Rehabilitation von alkoholabhängigen Menschen. Dies begründet sich aus den suchtbedingten Folgen im physischen, psychischen und sozialen Bereich. Die Zielsetzungen der Bewegungs- und Sporttherapie liegen dementsprechend in der Verbesserung der physischen Funktionen, der Stärkung psychosozialer Ressourcen sowie der Hinführung zu einem körperlich aktiven Lebensstil und zu Gesundheitskompetenz. Hinsichtlich ihrer Evidenz liegen bisher wenige randomisierte Studien im Sinne der evidenzbasierten Medizin (EbM) vor. Unter deren Kriterien lassen sich komplementäre Therapien im stationären Bereich kaum sauber evaluieren. Hier sollte das Konzept der evidenzbasierten Praxis (EbP) ergänzend hinzutreten.Die vorliegende multizentrische Studie untersucht in diesem Sinne die subjektive Bewertung der Therapiemaßnahmen am Ende der stationären Behandlung hinsichtlich des Therapieerfolgs mittels eines standardisierten Fragebogens. Zudem sollten ausgewählte Faktoren innerhalb der Bewegungs- und Sporttherapie bewertet werden, die zu einem Behandlungserfolg beigetragen haben. Es konnten insgesamt die Werte von 218 Klienten statistisch ausgewertet werden. Die Ergebnisse verweisen zum einen auf die hohe Akzeptanz dieser Maßnahme im Rahmen der angebotenen Therapiemodule hin. Zum anderen kristallisierten sich drei nahezu gleichgewichtige Wirkfaktoren heraus, die als hilfreich angesehen wurden. Dies sind der gesundheitliche, der soziale sowie der sensitive und kognitive Benefit. Die Ergebnisse sollten für zukünftige Konzeptualisierungen der Bewegungs- und Sporttherapie sowie bei der Revision der Therapiestandards stärker berücksichtigt werden.
The Clinical Picture of a Bilateral Perisylvian Syndrome as the Initial Symptom of Mega-Corpus-Callosum Syndrome due to a MAST1-Gene Mutation
Authors: Hecher Laura , Johannsen Jessika , Bierhals Tatjana , Buhk Jan-Hendrik , Hempel Maja , Denecke Jonas 
Published: August 2020

AbstractCongenital bilateral perisylvian syndrome (CBPS) is a rare neurological disorder associated with typical clinical and imaging features such as bilateral symmetrical polymicrogyria, either exclusively or mainly affecting the perisylvian region of the brain. We present a girl with the typical clinical picture of a CBPS and a complex migration disorder, predominantly presenting as bilateral symmetrical polymicrogyria associated with corpus callosum hyperplasia, ventricular dilation, and pontine hypoplasia. At the age of 6 months, the girl showed a profound global developmental delay, seizures refractory to treatment, and severe oromotor dysfunction. Exome analysis revealed a de novo mutation in microtubule-associated serine/threonine kinase 1 (MAST1). Recently, mutations in this gene were described in six patients with a cortical migration disorder named mega-corpus-callosum syndrome with cerebellar hypoplasia. Although all patients present the clinical and imaging features of CBPS, a clear assignment between CBPS and MAST1 mutations has not been reported yet.
Mucosal Fenestration After 2% Chlorhexidine Extrusion Used in Substitution of Sodium Hypochlorite: A Case Report
Authors: Alves Flávio Rodrigues Ferreira , Marceliano-Alves Marília F. , Souza Aline Carvalho de , Campello Andrea Fagundes 
Published: August 2020

AbstractThis report describes a case of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) extrusion through the apical foramen, causing acute pain, swelling and mucosal fenestration. A 62-year-old woman was referred for endodontic treatment in the first left maxillary premolar with a diagnosis of necrotic pulp. After the root canal irrigation with 2.5% NaOCl, the patient felt a burning sensation and pain. Discrete swelling and redness were noted in the patient’s face at the end of the session. Antibiotic and corticosteroids were prescribed. In the next appointment, 2% CHX was used, but another episode of extrusion occurred, with a sudden acute pain and intense swelling within a few minutes after the injection. After 2 weeks, the patient exhibited a left-side facial swelling extending anterior and inferior to the left zygomatic arch and superior to the body of the mandible. Oral antibiotic and anti-inflammatory drugs were administered. After 10 days, the swelling had completely diminished, but a mucosal fenestration and tooth mobility were verified. A cone beam CT was requested and showed a periapical lesion involving both buccal and palatal roots. After a prosthetic evaluation, the tooth extraction was indicated. One week after tooth removal, the mucosa was completely healed.
Plate Removal after Internal Fixation of Limb Fractures: A Retrospective Study of Indications and Complications in 48 Horses
Authors: Donati Brice , Fürst Anton E. , Del Chicca Francesca , Jackson Michelle A. 
Published: August 2020

AbstractObjective The aim of this study was to determine the indications for, and complications of, plate removal surgery in horses that underwent internal fixation of limb fractures.Study Design Medical records of horses presented to our hospital between 1990 and 2015 for the removal of plates after treatment of limb fractures were reviewed. Data collected at the time of initial presentation, including signalment, history, fracture features and treatment and information about the indications, timing and complications of implant removal were reviewed.Results The most common bones involved were the ulna (n = 19) and third metacarpal and metatarsal bones (n = 14). A total of 63 plates were removed from 48 horses during 53 separate surgeries, and the complication rate was 6/48; six horses had complications related to implant removal, which included persistent infection (n = 1) and refracture (n = 5). Complications related to implant removal were associated with comminuted fractures (p = 0.002), age > 3 years (p = 0.016) and the presence of surgical site infection (p = 0.001).Conclusion Plate removal after fracture healing is necessary in patients with implant-associated clinical signs. There is a strong relationship between the complication rate and the degree of comminution of the original fracture, increasing age and the presence of surgical site infection. The surgeon must be aware of these risk factors when planning plate removal.
Publication Rate and Evidence-Based Evaluation of Abstracts Presented at the Annual Veterinary Orthopedic Society Conference
Authors: Kettleman William S. , Iuliani Matthew C. , Webb Brenna G. , Ceballos Joselys M. , Torres Bryan T. 
Published: August 2020

Abstract
Objectives Scientific abstracts are a common method for disseminating new research. There is no information on the publication rate of orthopaedic surgery abstracts presented at the annual Veterinary Orthopedic Society (VOS) Conference. The objectives of this study were to document the publication rate, the publication timeline and the level of evidence (LoE) of abstracts presented at an annual orthopaedic meeting.
Study Design All conference abstracts from the 2001 to 2014 annual VOS meeting were reviewed, and final publication was determined through a comprehensive bibliographic search.
Results Over 14 conferences, 1,112 scientific abstracts were presented with an overall publication rate of 47%. The majority of abstracts had low LoE scores, and those abstracts were published less timely than ones with higher LoE scores. Once presented, most abstracts took 1 year to be submitted and 2 years to be published. Dog (45%) and ex vivo (19%) studies were the most common. Publication occurred most frequently in Veterinary Surgery (40%), Veterinary and Comparative Orthopaedics and Traumatology (17%) and the American Journal of Veterinary Research (12%).
Conclusion The publication rate for abstracts presented at the annual VOS meeting is lower than those from a more generalized veterinary surgery conference. Publication occurs most frequently in a select group of journals, and the subject matter is limited in scope with a focus on dog and ex vivo studies. Overall, most abstracts presented at VOS contain a lower LoE.
Measuring Parental Presence in the Neonatal Intensive Care Unit
Authors: Powers Shelby A. , Taylor Katherine , Tumin Dmitry , Kohler John A. 
Published: August 2020

Parental presence is believed to improve outcomes for infants hospitalized in the neonatal intensive care unit (NICU). As a result, NICU policies and procedures have evolved to support parental presence, and a growing number of studies examine the role of parental presence in the NICU. However, the measurement of parental presence is not standardized, complicating assessment of its impact on child and parent outcomes across studies. We reviewed 29 studies that presented 27 distinct methods of quantifying parental presence in the NICU and reported associations of presence with patient demographics, parental engagement in the NICU, and outcomes for both infants and parents. This overview provides a foundation for standardizing and improving routine measurement of parental presence in the NICU.
Key Points
Pharmaceutical Expenditure Is Unchanged with Ultrasound-Guided Surfactant Administration
Authors: De Luca Daniele , Yousef Nadya 
Published: August 2020

Objective Semiquantitative lung ultrasound improves the timeliness of surfactant replacement, but its financial consequences are unknown. We aim to investigate if the ultrasound-guided surfactant administration influences the general costs of surfactant therapy for preterm neonates affected by respiratory distress syndrome.
Study Design This is a pharmacoeconomic, retrospective, and before-and-after study investigating the impact of ultrasound-guided surfactant replacement (echography-guided Surfactant THERapy [ESTHER]) on pharmaceutical expenditure within the ESTHER initiative. Data extracted from the institutional official database hosted by the hospital administration for financial management were used for the analysis. We analyzed the number of surfactant administrations in neonates of gestational age ≤326/7 weeks, and the number of surfactant vials used from January 1, 2014 to June 30, 2014 (i.e., during the period of standard surfactant administration policy) and from July 1, 2016 to December 31, 2018 (that is during ESTHER policy).
Results ESTHER did not modify surfactant use, as proportion of treated neonates with RDS receiving at least one surfactant dose (Standard: 21.3% vs. ESTHER: 20.9%; p = 0.876) or as proportion of used vials over the total number of vials opened for neonates of any gestational age (Standard: 37% vs. ESTHER: 35%; p = 0.509).
Conclusion Ultrasound-guided surfactant replacement using a semiquantitative lung ultrasound score in preterm infants with RDS does not change the global use of surfactant and the related expenditure.
Key Points
Demographic perspectives on the mortality of COVID-19 and other epidemics
Authors: Goldstein Joshua R. , Lee Ronald D. 
Published: August 2020

Significance
What would a hypothetical 1 million US deaths in the COVID-19 epidemic mean for mortality of individuals at the population level? Life expectancy for 2020 would drop by 2.9 y. Those dying would lose an average of 11.7 y of expected remaining life, while for the general population the loss of remaining life would be 0.2 y for elders (at age 80) and much less at younger ages. Mortality per person would be less than that of the Spanish flu, but closer to that of the opioid and HIV/AIDS epidemics, while far more concentrated in time. The standard valuation of averting 1.75 million deaths would be many trillions of dollars.
The Prologue toNarcopolisby Jeet Thayil in translation into German and Polish
Authors: Zyga Magdalena 
Published: August 2020

AbstractThe novel Narcopolis and its translations into German and Polish start with a prologue which consists of one long sentence. The aim of this paper is an analysis of this sentence with the use of a combination of three approaches: (1) the translation theory proposed by Barańczak (1992), (2) the approach posited byM. H. Freeman (2006), and (3) the DIMEAN model byWarnke and Spitzmüller (2008)with the view to check their usefulness for translation criticism and as support in a text analysis preceding translation. In the first step, the conceptual schemata of key importance for the text are sought. Subsequently, language features of key importance which allow for the schemata to materialize are identified in the original and the translation equivalents of these are compared. The results of the analysis indicate that the eclectic approach presented in the paper appears to be quite efficient and user-friendly.