bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value and Regulatory Network of Immune-Related Genes in Hepatocellular Carcinoma
Authors: Zhou Xiang , Zhang Keying , Yang Fa , Xu Chao , Jiao Jianhua , Zhao Xiaolong , Wang Yan , Liu Shaojie , Jiang Yao , Wen Weihong , Fu Zhaoying 
Published: December 2020

Abstract
Background: Hepatocellular carcinoma (HCC) is a disease with higher morbidity, mortality, and poor prognosis in the whole world. Understanding the crosslink between HCC and the immune system is essential for people to uncover a few potential and valuable therapeutic strategies. This study aimed to reveal the correlation between HCC and immune-related genes and establish a clinical evaluation model. Methods: We had analyzed the clinical information consisted of 373 HCC and 49 normal samples from the cancer genome atlas (TCGA). The differentially expressed genes (DEGs) were selected by the Wilcoxon test and the immune-related differentially expressed genes (IRDEGs) in DEGs were identified by matching DEGs with immune-related genes downloaded from the ImmPort database. Furthermore, the univariate Cox regression analysis and multivariate Cox regression analysis were performed to construct a prognostic risk model. Then, twenty-two types of tumor immune-infiltrating cells (TIICs) were downloaded from Tumor Immune Estimation Resource (TIMER) and were used to construct the correlational graphs between the TIICs and risk score by the CIBERSORT. Subsequently, the transcription factors (TFs) were gained in the Cistrome website and the differentially expressed TFs (DETFs) were achieved. Finally, the KEGG pathway analysis and GO analysis were performed to further understand the molecular mechanisms between DETFs and PDIRGs.Results: In our study, 5839 DEGs, 326 IRDEGs, and 31 prognosis-related IRDEGs (PIRDEGs) were identified. And 8 optimal PIRDEGs were employed to construct a prognostic risk model by multivariate Cox regression analysis. The correlation between risk genes and clinical characterizations and TIICs has verified that the prognostic model was effective in predicting the prognosis of HCC patients. Finally, several important immune-related pathways and molecular functions of the eight PIRDEGs were significantly enriched and there was a distinct association between the risk IRDEGs and TFs. Conclusion: The prognostic risk model showed a more valuable predicting role for HCC patients, and produced many novel therapeutic targets and strategies for HCC.
Overexpression of lncRNA ITGB2-AS1 Predicts Adverse Prognosis in Acute Myeloid Leukemia
Authors: Zhou Ying-li , Xu Zi-jun , Yao Dong-ming , Zhou Jing-dong , Zhang Ting- juan , Ma Ji-chun , Lin Jiang , Qian Jun 
Published: December 2020

Abstract
BackgroundIn recent years, lncRNA ITGB2-AS1 has been found to play important roles in the occurrence and development of human solid tumors. However, its role in hematological diseases, especially acute myeloid leukemia (AML), remains unclear. Therefore, the aim of this study was to identify the expression pattern of ITGB2-AS1 in AML patients and to further explore its clinical significance. MethodsITGB2-AS1 expression was analyzed in public datasets (including TCGA and GSE63270) and further validated in our cohort of 109 AML patients using real-time quantitative PCR (RQ-PCR). ResultsThe level of ITGB2-AS1 was up-regulated among two independent cohorts (TCGA, P<0.05; GSE63270, P<0.05), which was confirmed by our own data (P<0.05). Clinically, high ITGB2-AS1 expression was associated with older age (P=0.023) and lower complete remission (CR) rate (P=0.005). Multivariate analysis identified that high ITGB2-AS1 expression was an independent prognostic factor not only for CR rate (P=0.027) but also for overall survival (OS) time (P=0.011). ITGB2-AS1 was found positively correlated with ITGB2 expression in both TCGA (R=0.74, P<0.001) and our own data (R=0.881, P<0.001). Similarly, high ITGB2 expression was also associated with older age (P=0.02) and lower CR rate (P=0.015). Moreover, high ITGB2 expression also predicted worse OS (P=0.028). ConclusionITGB2-AS1 is overexpressed in AML and predicts poor prognosis in AML.
The Characteristics of Visual Function and Intervention in Deprivation Amblyopia in Limbal Dermoid Children After Keratoplasty: A Pilot Study of Adopting Flank-Mask Perceptual Learning
Authors: Zhong Jing , Wang Yiyao , Hu Xiaoqing , Feng Lei , Ye Qingqing , Luo Yiming , Morad Yair , Li Jinrong , Yuan Jin 
Published: December 2020

Abstract
BackgroundTo compare visual acuity and CSF improvement with perceptual learning versus part-time patching in limbal dermoid children after keratoplasty.MethodsAll children in the limbal dermoid and normal group underwent visual acuity and CSF evaluation, and the normal group wore the optical defocus to simulate the corresponding visual acuity of the limbal dermoid group. Among the limbal dermoid children, 9 underwent perceptual learning(PL), and 8 underwent part-time patching for 6 months and were followed for 6 months to evaluate visual acuity and CSF.ResultsRegarding CSF, the area under log CSF (AULCSF) and the cutoff spatial frequency (cutoff SF) were obviously reduced in the limbal dermoid group compared with the optical defocus group and normal viewing group (1.29±0.27 vs 0.40±0.05 vs 0.70±0.05, and 5.38±0.75 vs 8.81±0.74 vs 14.81±0.89, all p value <0.05). Following PL, visual acuity increased from 0.63±0.11 to 0.32±0.09 (P=0.04) . Contrast sensitivity increased mainly in the low special frequencies as AULCSF improved from 0.49±0.15 to 0.73±0.18 (P=0.32), 0.78±0.21 (P=0.28), 0.80±0.19 (P=0.22) and 1.06±0.20 (P=0.04) from baseline to the 6th month in the PL group, while it remained unchanged in the part-time patching group.ConclusionsChildren suffering from limbal dermoid with amblyopia exhibited CSF deficits and perceptual learning was found to improve VA and CSF in the amblyopic eye better than patching.Trial registration﻿The study was registered at clinicaltrials.gov (PRS, ID NCT03447041).
Pilot Testing of a New App for Prospective Evaluation of Health-related Quality of Life in Breast Cancer
Authors: Lund-Jacobsen Trine , Schwarz Peter 
Published: December 2020

Abstract
Background: Given that BC patients now live longer and have a higher survival rate, long-term side effects of primary treatment and patients' Life Quality (LQ) have become a more central issue. The purpose of this study was to investigate whether Life Quality changes after primary BC treatment.Method: A prospective cohort study was conducted including 149 Danish women with BC. Sixty had entered the date since chemotherapy termination and their daily measurement of QoL for mood in the app Bone@BC. All users can only enter the app with a Danish NemID and own mobile device. The app includes self-reported patient baseline characteristics related to BC treatment and simple self-reported data of LQ measured in mood, social life and wellbeing measured by fatigue, pain and appetite and physical activities. Results: During the pilot test period, 149 BC survivors entered baseline data. Of the 149 BC survivors 60 (40%) have entered chemotherapy history and LQ data. The mean age of the BC survivors was 58.2 ±9.6 years (range 27-78 years). Days since chemotherapy termination was with a mean of 450 days (range 54-5.175 days). In group A (n=20) 35% reported 0-365 days and in group B (n=39) 65% reported more than 365 days since chemotherapy termination. In the whole group 65% reported neutral mood. By division into group A vs. B showed that mood improve over time measured by several in group B had a neutral mood achieved. Half (53%) had a good social life. Similar changes were reported for pain with 79% reporting mild to moderate pain in the whole group, group A vs. B showed an increasing level of pain over time with 24% reporting moderate to severe pain in group B vs. 13% in group A. Finally, it was observed that 58% reported mild to moderate appetite and it is decreasing over time, 64% reported mild to moderate appetite in group B vs. 50% in group A. Conclusion: Our results indicate that BC survivors have impaired QoL up to several years after primary BC treatment but there is a trend of some improvement over time. Trial registration: ClinicalTrials.grov:NCT03784651
Validation and Factor Analysis of the Parental Bonding Instrument in Japanese Pregnant Women
Authors: Sato Maya , Okada Takashi , Morikawa Mako , Nakamura Yukako , Yamauchi Aya , Ando Masahiko , Ozaki Norio 
Published: December 2020

Abstract
The Parental Bonding Instrument (PBI) evaluates parental attitudes derived from an individual’s childhood experiences with their parents. The factor structure of the PBI differs depending on variables such as psychosocial factors including culture, race, sex, and psychological and social conditions of participants. Although previous studies of the relationship between perinatal depression and parenting experiences have used the factor structures of the PBI from the general population, it is unclear whether the same factor structures are appropriate in the highly variable perinatal period. In this study, complete responses to the PBI and the Edinburgh Postnatal Depression Scale (EPDS) were received from 932 primiparas at 25 weeks of gestation and at 1 month postpartum. An exploratory factor analysis was performed on half of the responses, and it was confirmed that the three factors were care, interference, and autonomy. Confirmatory factor analysis of the remaining half of the answers showed comprehensible fitness. Each factor showed a high degree of internal consistency, and each factor of the PBI correlated with the EPDS, indicating construct validity. The reliability and validity of the PBI in perinatal Japanese women were confirmed, and it was found that the PBI had a three-factor structure.
Evaluating Mental Health First Aid: an Evidence Synthesis Review of Published Empirical Studies.
Authors: Atanda Opeyemi , Callaghan Patrick , Vangeli Eleni , Reavey Paula , Carter Tim , Brown Steven D. , Durcan Graham , O'Shea Nick , White Sarah , Wood Kerry 
Published: December 2020

Abstract
Background: Mental Health First Aid (MHFA) has received substantial international attention since its founding in the late 1990s, with a growing evidence base relating to its nature and impact across a variety of settings. Aims: To identify the effectiveness of MHFA upon a range of outcomes, recipients, its cost-effectiveness, and the mechanisms of its effect.Method: A systematic evidence synthesisResults: Data from 65 studies show MHFA education improves trainees’ mental health literacy, their perceived confidence in helping people living with mental distress and their intentions to help such people. MHFA also raises employees’ knowledge of mental illnesses in the workplace. There was also evidence of MHFA trainees using aspects of the five-stage ALGEE MHFA approach in their helping behaviour. The quality of the studies in this review varied across different types of studies. No published studies to date have evaluated MHFA’s impact on recipient outcomes, articulated the mechanisms of its effect, its cost-effectiveness, or societal impact.Conclusions: MHFA remains popular, but evidence of its effectiveness upon those receiving it remains unknown. It is urgent to undertake studies testing the effectiveness and cost-effectiveness of MHFA upon recipients, as well as identifying, empirically, how MHFA works, for whom, under what conditions, and barriers to its implementation. Given that the enthusiasm and acceptance of MHFA appears widespread, systematic evaluations of its social impact are warranted.Registration: The review protocol has been submitted to the Open Science Framework (View-only link: https://osf.io/rj4uh/?view_only=d1f9f2ed73724b3f8075c0c4581d0d87).
Spermatogenesis Stimulation and Sperms' Activation by Direct and Gradual Electrical Shocks on Testis in Infertile Males
Authors: Hashim Hashim Talib Talib , Mostafa Morad Yaser Al , Reda Abdallah , Chowdhury Nazmus Sakib 
Published: December 2020

Abstract
Background: Up to 15% of couples are infertile. In up to half of these couples, male infertility plays a role. Male infertility is caused by low sperm production, irregular sperm function, or blockages preventing the sperm delivery. Illnesses, accidents, chronic health issues, lifestyle choices and other factors can play a role in causing infertility among men.Methodology: It is a randomized controlled, single-blind clinical trial was conducted among 90 participants who have been diagnosed with (Oligospermia, Hypospermia, Asthenozoospermia or Necrozoospermia). Of a sample obtained by masturbation all the participants underwent a semen examination of their semen count, volume and motility. Then they got a small device, the device gives up to 5 milliamps of electrical shock. A final checkup for all was performed after the fourth months, and the data was collected and compared between (before and after) semen analysis.Results: The findings indicate an improvement in the count, volume and motility of the sperms after being shocked electrically in comparison with the control group. By using ANOVA-test, there were a statistically significant differences between the first seminal analysis result with each of the other results independently while it was not with the control group. Conclusion: Many treatments are available for infertility and other therapies and drugs and some of them are complicated and difficult to use. This painless and healthy way of enhancing sperm movement and count can be used by the male himself conveniently and at home to improve his chance of fertilizing an ovum.Trial registration: NCT, NCT04173052. Registered 21 November 2019 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04173052
Collaborative Pharmacist–physician Medication Management for the Elderly With Chronic Kidney Disease and Polypharmacy
Authors: Kim A Jeong , Lee Hayeon , Shin Eun Jeong , Cho Eun Jung , Cho Yoon Sook , Lee Hajeong , Lee Ju-Yeun 
Published: December 2020

Abstract
Background: Inappropriate polypharmacy is likely in older adults with chronic kidney disease owing to the considerable burden of comorbidities. We aimed to evaluate the impact of a collaborative pharmacist–physician geriatric medication management service on the quality of medication use. Methods: We retrospectively reviewed the medical records of patients who received the geriatric medication management service in ambulatory care clinic in a single tertiary-care teaching hospital from May 2019 to December 2019. The quality of medication use was evaluated based on the numbers of medications and potentially inappropriate medications. We also evaluated the types of drug-related problems identified during medication management service and pharmacists’ interventions. Results: Drug use quality was assessed in 87 of 95 patients who received the service. After the provision of medication management service, the total numbers of medications and potentially inappropriate medications decreased from 13.5 ± 4.3 to 10.9 ± 3.8 (p < 0.001) and from 1.6 ± 1.4 to 1.0 ± 1.2 (p<0.001), respectively. Furthermore, the numbers of patients who received three or more central nervous system-active drugs and strong anticholinergic drugs decreased. Among the 354 drug-related problems identified, “missing patient documentation” was the most common, followed by “adverse effect” and “drug not indicated.” The most frequent intervention was “therapy stopped” (111, 31.4%).Conclusions: Polypharmacy and potentially inappropriate medications were prevalent in older adults with chronic kidney disease, and geriatric medication management service involving a collaboration between pharmacists and physicians improved the quality of medication use in this population.
Circulating miRNA Expression in Asthmatics is Age-related and Associated with Clinical Asthma Parameters, Respiratory Function and Systemic Inflammation
Authors: Wardzyńska Aleksandra , Małgorzata Pawełczyk , Rywaniak Joanna , Makowska Joanna Samanta , Brzeska Joanna Jamroz- , Kowalski Marek Leszek 
Published: December 2020

Abstract
Background: Asthma in elderly asthmatics (EA) may have a different course than in non-elderly asthmatics (nEA), which may be partially associated with age-dependent aberrant immune response. The aim of the study was to assess the association of serum miRNA expression with asthma characteristics and systemic inflammation markers in EA and nEA.Methods: In 28 EA and 31 nEA patients, control and severity of asthma, pulmonary function and FeNO were assessed. The control group included 59 age-matched non-asthmatics. Expression of selected miRNAs in serum was measured with RT-PCR, and proinflammatory cytokines were assayed by ELISA or flow cytometry. Results: EA had lower serum expression of miRNA -19b and -146a, while the nEA had a higher expression of miRNA -146a than controls. EA had a higher serum expression of miRNA -106a and -126a than nEA. In all asthmatics, miRNA -106a and -126a were correlated with age. Only in nEA, the expression of selected miRNAs was associated with the level of asthma control (assessed with ACT) and with airway inflammation, measured by FeNO concentration. Elevated levels of systemic inflammation markers were associated with impaired respiratory function in all asthmatics and with worsened asthma control in the elderly patients. A significant correlation was observed between serum levels of proinflammatory cytokines and selected miRNAs.Conclusion: Serum miRNA expression was correlated with clinical characteristics of asthma and systemic inflammation in an age-dependent fashion suggesting that miRNA may differentially contribute to asthma pathogenesis in elderly and non-elderly patients.
Short-Run and Long-Run Income Elasticity of Healthcare Expenditure in India: Role of Domestic Revenue and Public Debt
Authors: Behera Deepak Kumar , Dash Umakant 
Published: December 2020

Abstract
Existing literature argues that income growth is an important determinant for change in healthcare expenditure in developing economies. Most of them examine the elasticity of public health expenditure concerning per capita income while the role of fiscal policies – public revenue and public debt to determine the level of spending has never been studied. Therefore, this study examines the income elasticity of public health expenditure in both short-run and long-run by controlling domestic revenue, and public debt (i.e. borrowings) in India for the period from 1980-81 to 2015-16. The study follows three steps for empirical analysis. First, we test stationarity properties of variables using the Zivot and Andrews (ZA) unit root test assuming that the Indian economy might have experienced structural breaks at different time points. Second, we examine the cointegrating relationships among variables using the Auto-Regressive Distributed Lag (ARDL) bounds testing approach. Third, we estimate both short-run and long-run elasticity by controlling structural-breaks using the unrestricted Error-Correction Term (ECT). Our result finds that domestic revenue (i.e. tax and non-tax) shows a positive and statistically significant effect while public debt (i.e. domestic and external) shows a negative and statistically significant effect on health expenditure respectively. It implies that a 1 percent increase in revenue leads to a 0.78 percent increment in public health expenditure annually while a 1 percent increase in public debt leads to an -0.51 percent reduction in public health expenditure in the long-run. Our result suggests that conducive public finance policies and alternative revenue mobilization could be a potential strategy to increase the level of health spending in India.
Implementation of a Multifactorial Fall Intervention Model in Hospital: a Longitudinal Before-and-after Controlled Study From 2015 to 2018
Authors: Liao Changju , Guo Linghong , Wang Han , Wang Tengyong , Zhang Yuyang , Zhou Yuqing , Liu Yin 
Published: December 2020

Abstract
Background: Falls are serious public health problems associated with irreversible health consequences and substantial economic burden. To effectively reduce the incidence of falls and mitigate fall-related injuries, we designed and verified a multifactorial fall intervention model.Methods: The current study was a longitudinal before-and-after controlled investigation including 3 phases with clinical characteristics of fall patients retrospectively identified in phase 1, a multifactorial fall intervention model designed in phase 2 and prospectively evaluated in phase 3. Phase 1 and 2 were conducted based on 153,601 hospitalized patients between January 2015 and December 2016. Phase 3 was carried out based on 171,776 hospitalized patients between January 2017 and December 2018. The Pearson Chi-squared test was used to compare categorical variables and the Mann-Whitney non-parametric test was utilized for one-way ordered data.Results: In phase 1, baseline characteristics of 491 fall patients revealed that inpatients falls were highly associated with the age, medication and disease. In phase 2, a new multifactorial fall intervention model covering measures for fall prevention, fall-onset management and continuous improvement was developed. Phase 3 recorded a total of 396 falls and demonstrated a remarkably declined fall rate (Reduction in falls by 0.09%, p<0.001) and fall rate per 1000 patient-days (Reduction in falls/1000 patient-days by 0.07‰, p<0.001) as compared with phase 1. The adjusted incident rate ratio of fall was 1.443 (95%CI: 1.263-1.647) (Phase 1 vs. Phase 3). Furthermore, the occurrence and the severity of fall injuries in phase 3 were significantly lower than that in phase 1 (Z=-4.426, p<0.001). More specifically, the number of uninjured falls accounted for 42.42% in phase 3 in comparison of 32.99% in phase 1.Conclusions: This multifactorial fall intervention model exhibited favorable effect on reducing the occurrence of fall and fall injuries.
Task-Related Brain Oscillation and Coherence Analysis Between High and Low Cognitive Proficiencies in Preschoolers With Attention Deﬁcit Hyperactivity Disorder
Authors: Chen I-Chun , Chen Chia-Ling , Chang Chih-Hao , Fan Zuo-Cian , Chang Yang , Lin Dar-Shong , Lin Cheng-Hsiu , Ko Li-Wei 
Published: December 2020

Abstract
BackgroundEarly diagnosis and intervention is essential for children at risk of attention deﬁcit hyperactivity disorder (ADHD). For preschool-age children with ADHD, who have heterogeneous neurobehavioral deficits, the continuous performance test and quantitative electroencephalography (EEG) can facilitate clinical diagnosis. This study investigated EEG dynamics and task-based EEG coherence in preschoolers with ADHD, who exhibited varying cognitive proficiencies.MethodsThe participants comprised 54 preschoolers (aged 5–7 years), 18 and 16 of whom exhibited high and low cognitive proficiency (ADHD-H and ADHD-L, respectively). The remaining 20 children had typical development (TD). All the children underwent the Conners’ Kiddie Continuous Performance Test and wireless EEG recording under different task conditions (rest, fast, and slow). ResultsIn the slow-rate task condition, the task-related parietal delta power of preschoolers with ADHD-L was significantly higher than that of their peers with TD. In the fast-rate condition, the preschoolers with ADHD-L exhibited higher parietal delta and theta/beta ratio as well as lower parietal beta power than those with ADHD-H. Unlike those in the TD group, the alpha power values of the participants in both the ADHD groups declined from rest to the task conditions. Task- related EEG beta coherence was decreased in both ADHD groups, which were distinct with TD groups. Conclusion﻿The aforementioned findings suggest that task-related brain oscillations were related to cognitive proficiency in preschool children with ADHD. The novel wireless EEG system used was demonstrated to be convenient and highly suitable for clinical use in preschool children. The EEG profiles in the present study may contain specific neural biomarkers that can assist early detection, diagnosis, and clinical planning for the treatment of ADHD in preschool children.