bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial
Authors: Widodo Johannes 
Published: January 2020

Writing is an indispensable part of research culture, and publication is one way to disseminate ideas and to push forward the scientific discourse in the pursuit of new knowledge, from theoretical- to praxis- levels. Especially for young scholars, writing and publishing in academic journals shall become a natural habit, not just for chasing credit points or impact factors, but for strengthening the true desire in finding new knowledge, ethically and scientifically.
There are four different categories of articles in this issue. First category is on the correlation between ecological-environmental aspects and tourism in rural-traditional contexts, where the writers have shown their critical position towards cultural & natural conservation. Second category is on architectural styles and typology which are more descriptive. Third category is related to the climatic comfort and simulation. And the fourth category is on human activities in urban space.
The article by Anna Pudianti and Vincentia Reni Vitasurya is looking into the ecological footprints in relation to village tourism in Yogyakarta from the anthropological perspective. Similar interest to village tourism and cultural-environmental conservation in Nias is shared by Anugerah Septiaman Harefa. Likewise, Rachmat Budihardjo is looking into the impact of tourism to the typological adaptation of the traditional architecture in Bali.
Dessy Anggaini and Dwita Hadi Rahmi wrote about “Indisch-style” based on typological inventory in Yogyakarta. Anneke Clauvinia Patriajaya and Yohanes Karyadi Kusliansjah are lamenting on the transformation of urban street character in Surabaya. Tine Abrianti and Purnama Salura wrote the sacred poetic of religious architecture in Jakarta.
Rivena Elbes and Ai Siti Munawaroh article is on thermal comfort study on a library building in Lampung. Leonardus Murialdo Fransiskus Purwanto presented his analysis on heat transfer by a thermal simulation software.
Finally, Raden Rangga Ilham Irfandian and Herman Wilianto presented their study on lifestyle aspect in urban public space in Bandung.
This journal edition demonstrates the diversity of interests and approaches among young scholars. Although the level of criticality and the level of theoretical discourse can still be improved further, but these articles have shown a good promise for a higher level of scholarly pursuits.
INTENSITAS ASUPAN GIZI DALAM MENGEMBANGKAN KESEHATAN ANAK USIA 5-6 TAHUN DI TK UMMI ERNI DESA PEMATANG JOHAR
Authors: Indriani Reka , Mesiono Mesiono , Sapri Sapri 
Published: January 2020

<p><em>When children are in a process of growth and rapid development, parents and young people should pay atantion to the health and health of children so that the children can grow and develop according to their age.The purpose of this research is to identify: (1). The children nutrition 5-6 years old, (2). The children health development 5-6 years old, (3). The alternative to protect children health. This research is a quantitative descriptive research. The participants of this research which are include the principal, teacher, and the student parents at class B who is 5-6 years old. In process of collecting the data the researcher used interview method, observation, and documentation. From the research we can conclude 1).Nutrition or food that often given to the children is just four healthy five perfect foods, 2).The children in TK Ummi are the children who have healtiness, 3). The alternative that can be commited to protect the children health is do the practice, make the children common to throw the rubbish in the right place, check the children nail, stock the pure water, set many dustbins and make a common to wash their hand before eating.</em></p>
PENGARUH PENERAPAN PERMAINAN MAGIC BOX (KOTAK MISTERI) TERHADAP PERKEMBANGAN BAHASA ANAK USIA 5-6 TAHUN DI RA AL-FAJAR MEDAN DENAI
Authors: Simamora Laili Hajriah , Hasibuan Humaidah Br. , Lubis Zulfahmi 
Published: January 2020

<em>This study aims to determine: 1) the effect of the application of the game magic box on the language development of children aged 5-6 years; 2) the effect of the quiz / question and answer method on language development of children aged 5-6 years; 3) differences in the application of the game magic box with question and answer method for language development of children aged 5-6 years at RA Al-Fajar Medan Denai. The method used is quantitative research, the type of research is quasi experimental design using post-test design control group design (non equivalent control group design). The population is 26, namely 13 children of class B1 (experimental class) and 13 children of class B2 (control class). The results of this study are 1) The influence of the application of the game magic box on language development of children aged 5-6 years, seen from the calculated value = 10.2700&gt; table = 2.064; 2) The influence of the question and answer method on the development the language of children aged 5-6 years, seen from the calculated value = 8.6782&gt; table = 2.064; 3) There are differences in the influence of the application of the magic box (mystery box) with the quiz / question and answer method on the language development of children aged 5-6 years in RA Al-Fajar Medan Denai, seen from the calculated value = 2.7458 and table = 2.064.</em>
Reversibility of impaired brain structures after transsphenoidal surgery in Cushing’s disease: a longitudinal study based on an artificial intelligence–assisted tool
Authors: Hou Bo , Gao Lu , Shi Lin , Luo Yishan , Guo Xiaopeng , Young Geoffrey S. , Qin Lei , Zhu Huijuan , Lu Lin , Wang Zihao , Feng Ming , Bao Xinjie , Wang Renzhi , Xing Bing , Feng Feng 
Published: January 2020

OBJECTIVECushing’s disease (CD) involves brain impairments caused by excessive cortisol. Whether these impairments are reversible in remitted CD after surgery has long been controversial due to a lack of high-quality longitudinal studies. In this study the authors aimed to assess the reversibility of whole-brain changes in remitted CD after transsphenoidal surgery (TSS), and its correlations with clinical and hormonal parameters, in the largest longitudinal study cohort to date for CD patient brain analysis.METHODSFifty patients with pathologically diagnosed CD and 36 matched healthy controls (HCs) were enrolled in a tertiary comprehensive hospital and national pituitary disease registry center in China. 3-T MRI studies were analyzed using an artificial intelligence–assisted web-based autosegmentation tool to quantify 3D brain volumes. Clinical parameters as well as levels of serum cortisol, adrenocorticotrophic hormone (ACTH), and 24-hour urinary free cortisol were collected for the correlation analysis. All CD patients underwent TSS and 46 patients achieved remission. All clinical, hormonal, and MRI parameters were reevaluated at the 3-month follow-up after surgery.RESULTSWidespread brain volume loss was observed in active CD patients compared with HCs, including total gray matter (p = 0.003, with false discovery rate [FDR] correction) and the frontal, parietal, occipital, and temporal lobes; insula; cingulate lobe; and enlargement of lateral and third ventricles (p < 0.05, corrected with FDR). All affected brain regions improved significantly after TSS (p < 0.05, corrected with FDR). In patients with remitted CD, total gray matter and most brain regions (except the frontal and temporal lobes) showed full recovery of volume, with volumes that did not differ from those of HCs (p > 0.05, corrected with FDR). ACTH and serum cortisol changes were negatively correlated with brain volume changes during recovery (p < 0.05).CONCLUSIONSThis study demonstrates the rapid reversal of total gray matter loss in remitted CD. The combination of full recovery areas and partial recovery areas after TSS is consistent with the incomplete recovery of memory and cognitive function observed in CD patients in clinical practice. Correlation analyses suggest that ACTH and serum cortisol levels are reliable serum biomarkers of brain recovery for clinical use after surgery.
In vitro and in vivo characterization of a cranial window prosthesis for diagnostic and therapeutic cerebral ultrasound
Authors: Prada Francesco , Franzini Andrea , Moosa Shayan , Padilla Frederic , Moore David , Solbiati Luigi , DiMeco Francesco , Legon Wynn 
Published: January 2020

OBJECTIVEThe authors evaluated the acoustic properties of an implantable, biocompatible, polyolefin-based cranial prosthesis as a medium to transmit ultrasound energy into the intracranial space with minimal distortion for imaging and therapeutic purposes.METHODSThe authors performed in vitro and in vivo studies of ultrasound transmission through a cranial prosthesis. In the in vitro phase, they analyzed the transmission of ultrasound energy through the prosthesis in a water tank using various transducers with resonance frequencies corresponding to those of devices used for neurosurgical imaging and therapeutic purposes. Four distinct, single-element, focused transducers were tested at fundamental frequencies of 500 kHz, 1 MHz, 2.5 MHz, and 5 MHz. In addition, the authors tested ultrasound transmission through the prosthesis using a linear diagnostic probe (center frequency 5.3 MHz) with a calibrated needle hydrophone in free water. Each transducer was assessed across a range of input voltages that encompassed their full minimum to maximum range without waveform distortion. They also tested the effect of the prosthesis on beam pressure and geometry. In the in vivo phase, the authors performed ultrasound imaging through the prosthesis implanted in a swine model.RESULTSAcoustic power attenuation through the prosthesis was considerably lower than that reported to occur through the native cranial bone. Increasing the frequency of the transducer augmented the degree of acoustic power loss. The degradation/distortion of the ultrasound beams passing through the prosthesis was minimal in all 3 spatial planes (XY, XZ, and YZ) that were examined. The images acquired in vivo demonstrated no spatial distortion from the prosthesis, with spatial relationships that were superimposable to those acquired through the dura.CONCLUSIONSThe results of the tests performed on the polyolefin-based cranial prosthesis indicated that this is a valid medium for delivering both focused and unfocused ultrasound and obtaining ultrasound images of the intracranial space. The prosthesis may serve for several diagnostic and therapeutic ultrasound-based applications, including bedside imaging of the brain and ultrasound-guided focused ultrasound cerebral procedures.
Critical area for memory decline after mesial temporal resection in epilepsy patients
Authors: Kim Dahye , Kim June Sic , Jeong Woorim , Shin Min-Sup , Chung Chun Kee 
Published: January 2020

OBJECTIVEMesial temporal lobe epilepsy (MTLE) surgery is associated with a risk of memory decline after surgery, but the effect of the extent and locus of temporal resection on postoperative memory function are controversial. The authors’ aim in this study was to confirm if selective resection is effective in preserving memory function and identify critical areas for specific memory decline after temporal resection.METHODSIn this single-center retrospective study, the authors investigated data from patients who underwent unilateral MTLE surgery between 2005 and 2015. Data from 74 MTLE patients (60.8% of whom were female; mean [SD] age at surgery 32 years [8.91 years] and duration of epilepsy 16 years [9.65 years]) with histologically proven hippocampal sclerosis were included. Forty-two patients underwent left-sided surgery. The resection area was manually delineated on each patient’s postoperative T1-weighted images. Mapping was performed to see if the resected group, compared with the nonresected group, had worse postoperative memory in various memory domains, including verbal item, verbal associative, and figural memory.RESULTSOverall, 95.9% had a favorable epilepsy outcome. In verbal item memory, resection of the left lateral temporal area was related to postoperative decline in immediate and delayed recall scores of word lists. In verbal associative memory, resection of the anterior part of the left hippocampus, left parahippocampal area, and left lateral temporal area was related to postoperative decline in immediate recall scores of word pairs. Resection of the posterior part of the left hippocampus, left parahippocampal area, and left lateral temporal area was related to delayed recall scores of the same task. Similarly, in the figural memory, postoperative decline of immediate recall scores was associated with the resection of the anterior part of the right hippocampus, amygdala, parahippocampal area, and superior temporal area, and decline of delayed recall scores was related to resection of the posterior part of the right hippocampus and parahippocampal area.CONCLUSIONSUsing voxel-based analysis, which accounts for the individual differences in the resection, the authors found a critical region for postoperative memory decline that is not revealed in the region-of-interest or groupwise comparison. Particularly, resection of the hippocampus was related to associative memory. In both verbal and visual memory, resection of the anterior part of the hippocampus was associated with immediate recall, and resection of the posterior part of the hippocampus was associated with delayed recall. Therefore, the authors’ results suggest that selective resection may be effective in preserving postoperative memory decline.
MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness
Authors: Zhu Dimin , Xiao Zheng , Wang Zongming , Hu Bin , Duan Chengbin , Zhu Ziyan , Gao Nailin , Zhu Yonghong , Wang Haijun 
Published: January 2020

OBJECTIVETo date, long noncoding RNAs (lncRNAs) have proven to function as key regulators in tumorigenesis. Among these lncRNAs, MEG3 displays low levels in various neoplasms and tumor cell lines. However, the regulatory mechanism of MEG3 and MIR-376B-3P, one of the microRNAs from downstream gene clusters of the DLK1-MEG3 locus, remains insufficiently defined.METHODSThe authors used quantitative real-time polymerase chain reaction analysis to analyze whether decreased MEG3 and MIR-376B-3P expression levels were associated with the invasiveness of clinical nonfunctioning pituitary adenomas (CNFPAs) in 30 patients. Furthermore, functional experiments unveiled the pathophysiological role of MEG3, MIR-376B-3P, and HMGA2 in pituitary-derived folliculostellate (PDFS) cell lines. Moreover, dual-luciferase reporter assay, Western blot analysis, and immunofluorescence were applied to reveal the correlations among MEG3, MIR-376B-3P, and HMGA2.RESULTSMEG3 and MIR-376B-3P were decreased in patients with CNFPA, and their transcriptional levels were highly associated with invasive CNFPAs. Moreover, excessive expression of MEG3 and MIR-376B-3P inhibited tumorigenesis and promoted apoptosis in PDFS cells. Importantly, the authors found that MEG3 acted as an enhancer of MIR-376B-3P expression. Furthermore, as a target gene of MIR-376B-3P, HMGA2 served as an oncogene in pituitary adenoma and could be negatively regulated by MEG3 via enriching MIR-376B-3P.CONCLUSIONSThis study offers a novel mechanism of an MEG3/MIR-376B-3P/HMGA2 regulatory network in CNFPAs, which may become a breakthrough for anticancer treatments.
Endoscopic approaches to orbital lesions: case series and systematic literature review
Authors: Zoli Matteo , Sollini Giacomo , Milanese Laura , La Corte Emanuele , Rustici Arianna , Guaraldi Federica , Asioli Sofia , Cirillo Luigi , Pasquini Ernesto , Mazzatenta Diego 
Published: January 2020

OBJECTIVESurgical treatment of orbital lesions is challenging because complex approaches with a high risk of postoperative sequelae are required. Recently, minimally invasive endoscopic approaches through endonasal (EEA) and transpalpebral (ETP) routes have been proposed. The objective of this study was to assess outcomes of EEA and ETP in the authors’ series of patients with orbital lesions.METHODSData from all patients who underwent operations for an orbital tumor through an endoscopic approach at the authors’ institution from 2002 to 2018 were retrospectively collected. All patients underwent preoperative MRI and ophthalmological evaluation, which was repeated 3 months after surgery and then at regular follow-up intervals. A systematic review of the literature was also performed using Medline, Embase, and Web of Science databases.RESULTSThe series includes 23 patients (14 males); the mean patient age was 48 ± 23.9 years. Most of the lesions were intraconal (n = 19, 83%). The more frequent histotype was cavernous hemangioma (n = 5, 22%). Exophthalmos was the most common symptom (21 of 23 patients). EEA was performed in 16 cases (70%) and ETP in 7 (30%). The aim of the surgery was achieved in 94% of the cases after an EEA (successful biopsy in 5 of 6 cases and radical resection in all 10 remaining patients), and in 86% after an ETP (successful biopsy in 2 cases and radical tumor resection in 4 of 5 cases). Complications consisted of 3 cases (13%) of transitory diplopia. One recurrence (4%) was observed at follow-up (mean 59 ± 55 months).CONCLUSIONSThe EEA and ETP have demonstrated to be safe and effective for tumors located respectively in medial and lateral quadrants, permitting one to approach orbital lesions endoscopically at 360°. Innovative surgical tools, including intraoperative ultrasonography, may be useful to potentially reduce surgical morbidity. Larger series are needed to validate these preliminary suggestions.
Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy
Authors: Park So Hee , Kim Myung Ji , Jung Hyun Ho , Chang Won Seok , Choi Hyun Seok , Rachmilevitch Itay , Zadicario Eyal , Chang Jin Woo 
Published: January 2020

OBJECTIVEGlioblastoma (GBM) remains fatal due to the blood-brain barrier (BBB), which interferes with the delivery of chemotherapeutic agents. The purpose of this study was to evaluate the safety and feasibility of repeated disruption of the BBB (BBBD) with MR-guided focused ultrasound (MRgFUS) in patients with GBM during standard adjuvant temozolomide (TMZ) chemotherapy.METHODSThis study was a prospective, single-center, single-arm study. BBBD with MRgFUS was performed adjacent to the tumor resection margin on the 1st or 2nd day of the adjuvant TMZ chemotherapy at the same targets for 6 cycles. T2*-weighted/gradient echo (GRE) MRI was performed immediately after every sonication trial, and comprehensive MRI was performed at the completion of all sonication sessions. Radiological, laboratory, and clinical evaluations were performed 2 days before each planned BBBD.RESULTSFrom September 2018, 6 patients underwent 145 BBBD trials at various locations in the brain. The authors observed gadolinium-enhancing spots at the site of BBBD on T1-weighted MRI in 131 trials (90.3%) and 93 trials (64.1%) showed similar spots on T2*-weighted/GRE MRI. When the 2 sequences were combined, BBBD was observed in 134 targets (92.4%). The spots disappeared on follow-up MRI. There were no imaging changes related to BBBD and no clinical adverse effects during the 6 cycles.CONCLUSIONSThis study is the first in which repetitive MRgFUS was performed at the same targets with a standard chemotherapy protocol for malignant brain tumor. BBBD with MRgFUS was performed accurately, repeatedly, and safely. Although a longer follow-up period is needed, this study allows for the possibility of other therapeutic agents that previously could not be used due to the BBB.Clinical trial registration no.: NCT03712293 (clinicaltrials.gov)
Predictors of recurrence and high growth rate of residual meningiomas after subtotal resection
Authors: Materi Joshua , Mampre David , Ehresman Jeff , Rincon-Torroella Jordina , Chaichana Kaisorn L. 
Published: January 2020

OBJECTIVEThe extent of resection has been shown to improve outcomes in patients with meningiomas. However, resection can be complicated by constraining local anatomy, leading to subtotal resections. An understanding of the natural history of residual tumors is necessary to better guide postsurgical management and minimize recurrence. This study seeks to identify predictors of recurrence and high growth rate following subtotal resection of intracranial meningiomas.METHODSAdult patients who underwent primary surgical resection of a WHO grade I meningioma at a tertiary care institution from 2007–2017 were retrospectively reviewed. Volumetric tumor measurements were made on patients with subtotal resections. Stepwise multivariate proportional hazards regression analyses were performed to identify factors associated with time to recurrence, as well as stepwise multivariate regression analyses to assess for factors associated with high postoperative growth rate.RESULTSOf the 141 patients (18%) who underwent radiographic subtotal resection of an intracranial meningioma during the reviewed period, 74 (52%) suffered a recurrence, in which the median (interquartile range, IQR) time to recurrence was 14 (IQR 6–34) months. Among those tumors subtotally resected, the median pre- and postoperative tumor volumes were 17.19 cm3 (IQR 7.47–38.43 cm3) and 2.31 cm3 (IQR 0.98–5.16 cm3), which corresponded to a percentage resection of 82% (IQR 68%–93%). Postoperatively, the median growth rate was 0.09 cm3/year (IQR 0–1.39 cm3/year). Factors associated with recurrence in multivariate analysis included preoperative tumor volume (hazard ratio [HR] 1.008,95% confidence interval [CI] 1.002–1.013, p = 0.008), falcine location (HR 2.215, 95% CI 1.179–4.161, p = 0.021), tentorial location (HR 2.410, 95% CI 1.203–4.829, p = 0.024), and African American race (HR 1.811, 95% CI 1.042–3.146, p = 0.044). Residual volume (RV) was associated with high absolute annual growth rate (odds ratio [OR] 1.175, 95% CI 1.078–1.280, p < 0.0001), with the maximum RV benefit at < 5 cm3 (OR 4.056, 95% CI 1.675–9.822, p = 0.002).CONCLUSIONSBy identifying predictors of recurrence and growth rate, this study helps identify potential patients with a high chance of recurrence following subtotal resection, which are those with large preoperative tumor volume, falcine location, tentorial location, and African American race. Higher RVs were associated with tumors with higher postoperative growth rates. Recurrences typically occurred 14 months after surgery.