bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights on cross-species transmission of SARS-CoV-2 from structural modeling
Authors: Rodrigues João PGLM , Barrera-Vilarmau Susana , Teixeira João MC , Seckel Elizabeth , Kastritis Panagiotis , Levitt Michael 
Published: June 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global pandemic that has infected more than 14 million people in more than 180 countries worldwide. Like other coronaviruses, SARS-CoV-2 is thought to have been transmitted to humans from wild animals. Given the scale and widespread geographical distribution of the current pandemic, the question emerges whether human-to-animal transmission is possible and if so, which animal species are most at risk. Here, we investigated the structural properties of several ACE2 orthologs bound to the SARS-CoV-2 spike protein. We found that species known not to be susceptible to SARS-CoV-2 infection have non-conservative mutations in several ACE2 amino acid residues that disrupt key polar and charged contacts with the viral spike protein. Our models also predict affinity-enhancing mutations that could be used to design ACE2 variants for therapeutic purposes. Finally, our study provides a blueprint for modeling viral-host protein interactions and highlights several important considerations when designing these computational studies and analyzing their results.
Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes
Authors: Dar Daniel , Thomashow Linda S. , Weller David M. , Newman Dianne K. 
Published: June 2020

AbstractPhenazines are natural bacterial antibiotics that can protect crops from disease. However, for most crops it is unknown which producers and specific phenazines are ecologically relevant, and whether phenazine biodegradation can counter their effects. To better understand their ecology, we developed and environmentally-validated a quantitative metagenomic approach to mine for phenazine biosynthesis and biodegradation genes, applying it to >800 soil and plant-associated shotgun-metagenomes. We discover novel producer-crop associations and demonstrate that phenazine biosynthesis is prevalent across habitats and preferentially enriched in rhizospheres, whereas biodegrading bacteria are rare. We validate an association between maize andDyella japonica, a putative producer abundant in crop microbiomes.D. japonicaupregulates phenazine biosynthesis during phosphate limitation and robustly colonizes maize seedling roots. This work provides a global picture of phenazines in natural environments and highlights plant-microbe associations of agricultural potential. Our metagenomic approach may be extended to other metabolites and functional traits in diverse ecosystems.
Molecular basis for recognition ofListeriacell wall teichoic acid by the pseudo-symmetric SH3b-like repeats of a bacteriophage endolysin
Authors: Shen Yang , Kalograiaki Ioanna , Prunotto Alessio , Dunne Matthew , Boulos Samy , Taylor Nicholas M.I. , Sumrall Eric , Eugster Marcel R. , Martin Rebecca , Julian-Rodero Alicia , Gerber Benjamin , Leiman Petr G. , Menéndez Margarita , Peraro Matteo Dal , Cañada Francisco Javier , Loessner Martin J. 
Published: June 2020

AbstractEndolysins are bacteriophage-encoded peptidoglycan hydrolases targeting the cell wall of host bacteria via their cell wall-binding domains (CBDs). The molecular basis for selective recognition of surface carbohydrate ligands by CBDs remains elusive. Here, we describe, in atomic detail, the interaction between theListeriaphage endolysin domain CBD500 and its cell wall teichoic acid (WTA) ligands. We show that 3’O-acetylated GlcNAc residues integrated into the WTA polymer chain are the key epitope recognized by a CBD binding cavity located at the interface of tandem copies ofbeta-barrel, pseudo-symmetric SH3b-like repeats. This cavity consists of multiple aromatic residues making extensive interactions with two GlcNAc acetyl groups via hydrogen bonds and van der Waals contacts, while permitting the docking of the diastereomorphic ligands. The multidisciplinary approach described here delineates a previously unknown recognition mechanism by which a phage endolysin specifically recognizes and targets WTA, suggesting an adaptable model for regulation of endolysin specificity.
Co-creating sustainable corporate brands: a consumer framing approach
Authors: Lahtinen Sonja , Närvänen Elina 
Published: June 2020

PurposeThe purpose of this research is to explore how consumers co-create sustainable corporate brands (SCBs) by framing brands with a newly adopted sustainability orientation.Design/methodology/approachThe qualitative data were generated from four focus groups consisting of altogether 25 Finnish millennial consumers. The data were analysed using thematic analysis, and the resulting themes were classified as different framings.FindingsThe findings indicate three ways of framing SCBs: as signs of corporate hypocrite, as threats that increase societal fragmentation and as signs of corporate enlightenment. These framings are based on two components: the perceived attributes and activities of the corporate brand.Practical implicationsThe role of corporate brands is expanding from the business sphere towards actively influencing society. Yet, sustainability activities can be risky if consumers, as primary stakeholders, deem them unacceptable, unethical or untrustworthy. This research supports brand managers to succeed in co-creating SCBs as contributors to societal and environmental well-being, at a time when multiple stakeholders consider this a worthwhile endeavour.Originality/valueThe theoretical contribution is twofold: firstly, the paper extends the sustainable corporate branding literature by demonstrating how SCBs are co-created through an interactive framing process between the corporation and primary stakeholders, and, secondly, it contributes to the constitutive approach to corporate social responsibility communication (CSRC) research by showing how millennial consumers frame corporate brands that communicate corporations' newly adopted sustainability orientation.
Workplace accountabilities: worthy challenge or potential threat?
Authors: Brees Jeremy R. , Sikora David M. , Ferris Gerald R. 
Published: June 2020

PurposeCombining early and untested accountability perspectives with stress research, the authors examined the degree to which employees perceive workplace accountabilities as either worthy challenges to be overcome or potential threats to be avoided.Design/methodology/approachThe authors utilized structural equation modeling to evaluate our hypotheses and tested them across two data samples, using two different sampling techniques collected four years apart.FindingsEmployees' individual differences of attribution style, negative affectivity and core self-evaluations influenced how subjects approached accountability pressures in their workplace, which in turn, was associated with job satisfaction and turnover intentions.Originality/valueBy examining how employees evaluate accountability pressures, this investigation advances existing research by exploring the different ways in which employees perceive workplace accountabilities.
Leading by bribing: evidence from China
Authors: Li Shaomin 
Published: June 2020

PurposeThis study examines a new type of corruption that has not previously been studied but that significantly affects the world. Traditionally, corruption has referred to individuals or organizations that bribe state officials. The author examines a phenomenon in which the briber is actually the government of a country that bribes the rest of the world in order to gain influence and propose a framework to explain it.Design/methodology/approachA multi-case qualitative method is used to compile and analyze evidences and develop my arguments. Specifically, the author compiles information on and analyzes the Confucius Institutes, the training of future foreign leaders, influencing the influencers, the Thousand Talents Plan, the Belt and Road Initiative and foreign aid.FindingsThe findings reveal the existence of state-sponsored bribery of the world.Social implicationsState-sponsored bribery is a threat to the world. Recognizing it is the first step to curb it. Reducing the bribery by China's state will benefit the world and China.Originality/valueState-sponsored bribery is originally defined and documented. A framework about the motivations and capabilities of state-sponsored bribery is proposed, the effects of and responses to such a bribery are reviewed, and policies to curb it are suggested.
The status quo and the investment decisions
Authors: EL Harbi Sana , Toumia Oumeima 
Published: June 2020

PurposeThis article investigates the influence of status quo bias (SQB) on venture capital investments.Design/methodology/approachThe authors use the dynamic panel probit (respectively logit) model for 24 countries over nine years (from 2007–2015).FindingsThe authors’ regressions reveal that the SQB is meaningful in real decisions. Indeed, the authors find that the choice of investment sectors depends positively on the previous choice. Moreover, the study identifies other factors that were perceived to influence the choice of the investment industry such as added value by activity and the venture capital (VC) country attractiveness index.Practical implicationsBy knowing the behavior of VC FIRMS, entrepreneurs would better frame their business plans and better target the VC to whom they should better contact.Originality/valueNo research has dealt with this question, yet status quo is consensually recognized as an omnipresent institutional factor.
A retrospective evaluation of Marketing Intelligence and Planning: 1983–2019
Authors: Donthu Naveen , Kumar Satish , Pandey Nitesh 
Published: June 2020

PurposeThe purpose of this study is to map the development of articles published, citations, and themes of Marketing Intelligence and Planning (MIP) over the 37-year period of 1983–2019.Design/methodology/approachThis study uses the Scopus database to identify the most-cited MIP articles and most-included authors, institutions and countries in MIP. The study uses bibliometric indicators, as well as tools such as bibliographic coupling, performance analysis and science mapping, to analyze the publication and citation structure of MIP. The study provides a temporal analysis of MIP publishing across different time periods.FindingsMIP has an average publication of 43 articles each year, and the number of citations has grown substantially since it started publication. Although contributors to the journal come from around the globe, they most often are affiliated with the United Kingdom, United States, and Australia. Bibliographic coupling of documents reveals that the journal's primary focus has been on issues such as marketing planning, marketing theory, consumer behavior, global marketing, customer relationship management, customer service and branding. Co-authorship analysis reveals that the journal's collaborative network has grown.Research limitations/implicationsThis study uses data from the Scopus database, and any limitations of the database have implications for the findings.Originality/valueFirst analysis of this kind of papers published in MIP
NANDA‐I, NOC, and NIC Linkages to SARS‐Cov‐2 (Covid‐19): Part 1. Community Response
Authors: Moorhead Sue , Macieira Tamara Gonçalves Rezende , Lopez Karen Dunn , Mantovani Vanessa Monteiro , Swanson Elizabeth , Wagner Cheryl , Abe Noriko 
Published: June 2020

PURPOSEWe developed linkages using interoperable standardized nursing terminologies, NANDA International (NANDA‐I) nursing diagnoses, Nursing Interventions Classification (NIC), and Nursing Outcomes Classification (NOC), to present initial guidance for the development of care plans focused on COVID‐19 for nurses practicing in community or public health roles.METHODSSeven nurse experts identified the linkages of NANDA‐I, NOC and NIC for our work related to the COVID‐19 pandemic. A model was developed to guide the project. The first step in creating linkages focused on the identification of nursing diagnoses. Then, for each nursing diagnosis, outcomes aligned with all components of the diagnosis were categorized and a list of nursing interventions was selected. The experts used their clinical judgment to make final decisions on the linkages selected in this study.FINDINGSTwo community level nursing diagnoses were identified as key problems appropriate for a pandemic related to COVID‐19: Deficient Community Health and Ineffective Community Coping. For the nursing diagnosis Deficient Community Health, eight nursing outcomes and 12 nursing interventions were selected. In comparison for the nursing diagnosis, Ineffective Community Coping, nine nursing outcomes and 18 nursing interventions were identified. A total of40 concepts were identified for future development across the three classifications.CONCLUSIONSThe nursing diagnoses, outcomes and interventions selected during this linkage process provide knowledge to support the community challenged with responding to the COVID‐19 pandemic, provide the opportunity to quantify the impact of nursing care, and enhance nursing practice by promoting the use of three standardized terminologies.IMPLICATIONS FOR NURSING PRACTICENANDA‐I, NOC and NIC linkages identified in this manuscript provide resources to support clinical decisions and care plan development for nurses practicing in the community.
Randomized controlled trial of multi‐modular motion‐assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment‐resistant post‐traumatic stress disorder
Authors: Bisson J. I. , van Deursen R. , Hannigan B. , Kitchiner N. , Barawi K. , Jones K. , Pickles T. , Skipper J. , Young C. , Abbott L. R. , van Gelderen M. , Nijdam M. J. , Vermetten E. 
Published: June 2020

ObjectiveTo explore the potential efficacy of multi‐modular motion‐assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment‐resistant service‐related PTSD.MethodsExploratory single‐blind, randomized, parallel arm, cross‐over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.ResultsA total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician‐Administered PTSD Scale for DSM‐5 scores between the immediate and delayed 3MDR arms was −9.38 (95% CI −17.33 to −1.44, P = 0.021) at 12 weeks and −3.59 (−14.39 to 7.20, P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26‐week follow‐up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified.Conclusion3MDR is a promising new intervention for treatment‐resistant PTSD with emerging evidence of effect.
Cultural values in Chinese proverbs reported by Chinese college students
Authors: Weng Liping , Zhang Yan Bing , Kulich Steve J. , Zuo Chengli 
Published: June 2020

Proverbs listed by Chinese college students, who are often at the leading edge of cultural change, provide a window into the dynamic interplay of traditionality and modernity. Using thematic analysis, Study 1 examined popular proverbs listed frequently by Chinese college students (n = 298) and the embedded values. Study 2, which was a survey, examined Chinese college students’ (n = 240) endorsement of individualism, collectivism, and the values identified in Study 1, and the predictive associations of individualism and collectivism with the values. Findings in Study 1 revealed 103 frequently listed proverbs and eight embedded values (i.e., Learnedness, Diligence, Practical Orientation, Collective Orientation, Social Relationship, Moral Virtue, Free Spirit, and Optimism). Findings in Study 2 indicated participants endorsed Practical Orientation and Learnedness the most, followed by Diligence, Moral Virtue, Social Relationship, Collective Orientation, Optimism, and Free Spirit. Furthermore, although Chinese young adults are more individualistic than collectivistic, collectivism remains a stronger predictor of the values uncovered in the proverbs. The value dynamics in general revealed tensions and harmony between Confucianism and Daoism and the hybridisation of tradition, modernisation, and Western individualism, thus reflecting the complexity of Chinese young adults’ social psychology.
No effects of a 6‐week intervention with a glucagon‐like peptide‐1 receptor agonist on pancreatic volume and oedema in obese men without diabetes
Authors: Svane Maria S. , Johannesen Helle H. , Martinussen Christoffer , Bojsen‐Møller Kirstine N. , Hansen Martin Lundsgaard , Hansen Adam E. , Deacon Carolyn F. , Hartmann Bolette , Keller Sune H. , Klausen Thomas L. , Loft Annika , Kjaer Andreas , Madsbad Sten , Löfgren Johan , Holst Jens J. , Wewer Albrechtsen Nicolai J. 
Published: June 2020

AbstractAimTo investigate the effect of a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans.Materials and MethodsWe performed an open‐label study in 14 obese men (age 38 ± 11 years, body mass index 32 ± 4 kg/m2) without diabetes. Subjects were examined at baseline, during titration (week 4) of liraglutide towards 3.0 mg/day, and 2 weeks after steady‐state treatment (week 6) of a final dose of liraglutide. The primary endpoint was pancreatic volume determined by magnetic resonance imaging. Secondary endpoints included pancreatic oedema and cellularity, positron emission tomography‐based [18F]fluorothymidine (FLT) uptake (DNA synthesis) and plasma pancreatic enzymes.ResultsPlasma amylase (+7 U/L [95% confidence intervals 3‐11], P < .01) and lipase (+19 U/L [7‐30], P < .01) increased during liraglutide treatment. Pancreatic volume did not change from baseline to steady state of treatment (+0.2 cm3 [−8‐8], P = .96) and no change in pancreatic cellular infiltration was found (P = .22). During titration of liraglutide, FLT uptake in pancreatic tissue increased numerically (+0.08 [0.00‐0.17], P = .0507).ConclusionsSix weeks of treatment with liraglutide did not affect pancreatic volume, oedema or cellularity in obese men without diabetes.
Shared ancestral polymorphisms and chromosomal rearrangements as potential drivers of local adaptation in a marine fish
Authors: Cayuela Hugo , Rougemont Quentin , Laporte Martin , Mérot Claire , Normandeau Eric , Dorant Yann , Tørresen Ole K. , Hoff Siv Nam Khang , Jentoft Sissel , Sirois Pascal , Castonguay Martin , Jansen Teunis , Praebel Kim , Clément Marie , Bernatchez Louis 
Published: June 2020

AbstractGene flow has tremendous importance for local adaptation, by influencing the fate of de novo mutations, maintaining standing genetic variation and driving adaptive introgression. Furthermore, structural variation as chromosomal rearrangements may facilitate adaptation despite high gene flow. However, our understanding of the evolutionary mechanisms impending or favouring local adaptation in the presence of gene flow is still limited to a restricted number of study systems. In this study, we examined how demographic history, shared ancestral polymorphism, and gene flow among glacial lineages contribute to local adaptation to sea conditions in a marine fish, the capelin (Mallotus villosus). We first assembled a 490‐Mbp draft genome of M. villosus to map our RAD sequence reads. Then, we used a large data set of genome‐wide single nucleotide polymorphisms (25,904 filtered SNPs) genotyped in 1,310 individuals collected from 31 spawning sites in the northwest Atlantic. We reconstructed the history of divergence among three glacial lineages and showed that they probably diverged from 3.8 to 1.8 million years ago and experienced secondary contacts. Within each lineage, our analyses provided evidence for large Ne and high gene flow among spawning sites. Within the Northwest Atlantic lineage, we detected a polymorphic chromosomal rearrangement leading to the occurrence of three haplogroups. Genotype–environment associations revealed molecular signatures of local adaptation to environmental conditions prevailing at spawning sites. Our study also suggests that both shared polymorphisms among lineages, resulting from standing genetic variation or introgression, and chromosomal rearrangements may contribute to local adaptation in the presence of high gene flow.
Distinguishing tectonic versus climatic forcing on landscape evolution: An example from SE Tibetan Plateau
Authors: Liu Fangbin , Danišík Martin , Zheng Dewen , Gallagher Kerry , Nie Junsheng 
Published: June 2020

AbstractDistinguishing climate from tectonic forcing in shaping the Earth’s surface has been a long-standing issue in the Earth sciences. Great debate exists regarding when and how the SE Tibetan Plateau achieved its current low-relief topography, and both lateral extrusion and lower crust flow have been proposed as the dominant mechanism. Reconstruction of the exhumation history of the SE Tibetan Plateau is key to understanding these formation processes and resolving the significance of different forcing mechanisms. Here we report zircon and apatite (U-Th)/He ages from steep transects across the Lincang granite belt of the SE Tibetan Plateau. Our results reveal a two-stage exhumation history during the Cenozoic with rapid cooling phases in the late Eocene and the middle Miocene. In the late Eocene, the climate was generally dry and there is plenty of evidence for increased extrusion and upper crustal shortening. We suggest tectonic processes are responsible for the first inferred cooling. In contrast, the Asian summer monsoon precipitation increased during the middle Miocene, and we posit the middle Miocene cooling phase records a phase of rapid river incision triggered by the intensified precipitation and associated fault movements. The results are consistent with recent paleo-altimetry work in this region suggesting that the present-day topography of the SE Tibetan Plateau had been largely constructed by the late Eocene. Together, these data suggest that extrusion and/or upper crustal shortening setup the first order topography of the SE Tibetan Plateau, which was then modified by climate-triggered fluvial incision and feedbacks initiated in the middle Miocene.