bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warwick electron microscopy datasets
Authors: Ede Jeffrey M 
Published: June 2020

Abstract
Large, carefully partitioned datasets are essential to train neural networks and standardize performance benchmarks. As a result, we have set up new repositories to make our electron microscopy datasets available to the wider community. There are three main datasets containing 19769 scanning transmission electron micrographs, 17266 transmission electron micrographs, and 98340 simulated exit wavefunctions, and multiple variants of each dataset for different applications. To visualize image datasets, we trained variational autoencoders to encode data as 64-dimensional multivariate normal distributions, which we cluster in two dimensions by t-distributed stochastic neighbor embedding. In addition, we have improved dataset visualization with variational autoencoders by introducing encoding normalization and regularization, adding an image gradient loss, and extending t-distributed stochastic neighbor embedding to account for encoded standard deviations. Our datasets, source code, pretrained models, and interactive visualizations are openly available at https://github.com/Jeffrey-Ede/datasets.
Format Effects of iPad Administration of Wechsler Adult Intelligence Scale–Fourth Edition: Cross-Sectional Evidence for Score Equivalency in Routine Clinical Practice
Authors: Young Stephanie Ruth 
Published: June 2020

Abstract

Objective
The literature lacks independent investigations of the influence of tablet administration of cognitive assessments in applied clinical settings. The present study examined the influence of iPad administration on (Wechsler Adult Intelligence Scale–Fourth Edition) WAIS-IV core subtest scores in a university-based clinic.

Method
Record review was conducted for a convenience sample (N = 66) of university students who were administered the WAIS-IV via iPad or traditional format. Bayesian difference testing was used to evaluate the strength of the evidence for subtest score equivalence across groups.

Results
Evidence supported score equivalency for the 10 core subtests across administration groups (BF &gt; 3). The one exception was digit span-forward condition, for which equivalence was supported (BF = 2.44), but did not meet cut-off criteria.

Conclusions
iPad administration of WAIS-IV is unlikely to influence subtest scores in routine clinical practice with healthy young adults. Further independent research in diverse clinical populations is recommended.
Biogeographical patterns and processes in the genus group Scotussae (Acrididae: Melanoplinae): an integrative approach
Authors: Scattolini María Celeste , Lira-Noriega Andrés , Confalonieri Viviana Andrea , Pietrokovsky Silvia , Cigliano María Marta 
Published: June 2020

AbstractA biogeographical study of the genus group Scotussae, a clade of grasshoppers endemic to the subtropical temperate region of the La Plata Basin, South America, was performed within a phylogenetic context to test whether wing reduction reflects evolutionary and ecological processes within the clade. We used an integrative biogeographical approach to determine the role of geohistorical events, geography, ecology and phylogenetic niche conservatism on the distribution and diversification processes of the group. We performed a total evidence phylogenetic analysis and tested the phylogenetic signal of ecological niche traits (niche optimum and niche breadth). We also assessed the degree to which phylogenetic distance is correlated with geographical and ecological niche traits and we used BioGeoBEARS to estimate ancestral ranges. The results provided evidence for phylogenetic niche conservatism as well as a significant association between phylogeny and both geographical and, more strongly, ecological traits. Two main clades were clearly associated with wing development, and evidence points to the evolutionary and ecological processes within these two groups being different. The Brachypterous clade shows evidence that allopatric speciation was the main source of diversification, while for the Macropterous clade sympatric speciation seems more likely.
Phylogenetic diversity of the lichenized algal genusTrebouxia(Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)
Authors: Xu Maonian , De Boer Hugo , Olafsdottir Elin Soffia , Omarsdottir Sesselja , Heidmarsson Starri 
Published: June 2020

AbstractLichens have high tolerance to harsh environmental conditions, where lichen symbiont interactions (e.g. myco- and photobionts) may play a crucial role. The characterization of fungal-algal association patterns is essential to understand their symbiotic interactions. This study investigated fungal-algal association patterns in Icelandic cetrarioid lichens using a multi-locus phylogenetic framework, including fungal nrITS, MCM7, mtSSU, RPB1 and RPB2 and algal nrITS, nrLSU, rbcL and mtCOXII data. Most Icelandic cetrarioid lichenized fungi were found to be specifically associated to the known Trebouxia clade “S” (Trebouxia simplex/suecica group), whereas the lichen-forming fungus Cetrariella delisei forms a symbiosis with a previously unrecognized lineage of Trebouxia, provisionally named as the “D” clade. This new Trebouxia lineage is supported by maximum likelihood and Bayesian phylogenetic analyses using all four included algal loci.
Signalling by Bayesian Persuasion and Pricing Strategy
Authors: Chen Yanlin , Zhang Jun 
Published: June 2020

Abstract
This article investigates how a privately informed seller could signal her type through Bayesian persuasion and pricing strategy. We find that it is generally impossible to achieve separation through one channel alone. Furthermore, the outcome that survives the intuitive criterion always exists and is unique. This outcome is separating, for which a closed-form solution is provided. The signalling concern forces the high-type seller to disclose inefficiently more information and charge a higher price, resulting in fewer sales and lower profit. Finally, we show that a regulation on minimal quality could potentially hurt social welfare, and private information hurts the seller.
A New High-Quality Draft Genome Assembly of the Chinese Cordyceps Ophiocordyceps sinensis
Authors: Shu Ruihao , Zhang Jihong , Meng Qian , Zhang Huan , Zhou Guiling , Li Miaomiao , Wu Peipei , Zhao Yanni , Chen Chao , Qin Qilian 
Published: June 2020

AbstractOphiocordyceps sinensis (Berk.) is an entomopathogenic fungus endemic to the Qinghai-Tibet Plateau. It parasitizes and mummifies the underground ghost moth larvae, then produces a fruiting body. The fungus-insect complex, called Chinese cordyceps or “DongChongXiaCao,” is not only a valuable traditional Chinese medicine, but also a major source of income for numerous Himalayan residents. Here, taking advantage of rapid advances in single-molecule sequencing, we assembled a highly contiguous genome assembly of O. sinensis. The assembly of 23 contigs was ∼110.8 Mb with a N50 length of 18.2 Mb. We used RNA-seq and homologous protein sequences to identify 8,916 protein-coding genes in the IOZ07 assembly. Moreover, 63 secondary metabolite gene clusters were identified in the improved assembly. The improved assembly and genome features described in this study will further inform the evolutionary study and resource utilization of Chinese cordyceps.
Genomics at cellular resolution: insights into cognitive disorders and their evolution
Authors: Berto Stefano , Liu Yuxiang , Konopka Genevieve 
Published: June 2020

Abstract
High-throughput genomic sequencing approaches have held the promise of understanding and ultimately leading to treatments for cognitive disorders such as autism spectrum disorders, schizophrenia and Alzheimer’s disease. Although significant progress has been made into identifying genetic variants associated with these diseases, these studies have also uncovered that these disorders are mostly genetically complex and thus challenging to model in non-human systems. Improvements in such models might benefit from understanding the evolution of the human genome and how such modifications have affected brain development and function. The intersection of genome-wide variant information with cell-type-specific expression and epigenetic information will further assist in resolving the contribution of particular cell types in evolution or disease. For example, the role of non-neuronal cells in brain evolution and cognitive disorders has gone mostly underappreciated until the recent availability of single-cell transcriptomic approaches. In this review, we discuss recent studies that carry out cell-type-specific assessments of gene expression in brain tissue across primates and between healthy and disease populations. The emerging results from these studies are beginning to elucidate how specific cell types in the evolved human brain are contributing to cognitive disorders.
What determines the size of contract research from firms to universities? The role of geographical distance and regional co-location
Authors: Spithoven André , Teirlinck Peter , Ysebaert Walter 
Published: June 2020

Abstract
This article explores the role of geographical distance and regional co-location as a determinant of the size of contract research from firms to domestic universities. The analysis relies on a panel of three consecutive R&D surveys for Belgium, and controls for firm, university, and network characteristics. The findings reveal that firms tend to enter into larger-sized contract research with universities that are either located nearby or farther away. Regional co-location is also positively associated with the size of contract research from firms to universities.
On the Positive Theory of Groups Acting on Trees
Authors: Casals-Ruiz Montserrat , Garreta Albert , de la Nuez González Javier 
Published: June 2020

Abstract
In this paper, we study the positive theory of groups acting on trees and show that under the presence of weak small cancellation elements, the positive theory of the group is trivial, that is, coincides with the positive theory of a non-abelian free group. Our results apply to a wide class of groups, including non-virtually solvable fundamental groups of 3-manifold groups, generalised Baumslag–Solitar groups and almost all one-relator groups and graph products of groups. It follows that groups in the class satisfy a number of algebraic properties: for instance, their verbal subgroups have infinite width and, although some groups in the class are simple, they cannot be boundedly simple.
In order to prove these results, we describe a uniform way for constructing (weak) small cancellation tuples from (weakly) stable elements. This result of interest in its own is fundamental to obtain corollaries of general nature such as a quantifier reduction for positive sentences or the preservation of the non-trivial positive theory under extensions of groups.
Anemia and thrombocytopenia in people living with HIV/AIDS: a narrative literature review
Authors: Marchionatti Amanda , Parisi Mariana Migliorini 
Published: June 2020

Abstract
Hematologic changes are frequent complications in people living with HIV/AIDS (PLWHA). Anemia and thrombocytopenia are the most frequent multifactorial hematologic abnormalities and are associated with a low quality of life and high death rates. This study aims to describe the prevalence of anemia and thrombocytopenia in PLWHA and to identify the main clinical characteristics that aggravate these conditions in studies published in the last 10 y. A comprehensive search was performed on the PUBMED database, using the terms ‘HIV infection and anemia’ and ‘HIV infection and thrombocytopenia’. Additional searches were made in the reference lists of articles covering the theme. The selected studies reported an overall prevalence of anemia from 7.2% to 84% and of thrombocytopenia from 4.5% to 26.2%. The prevalence of thrombocytopenia and anemia were aggravated by a CD4+ T lymphocyte count of &lt;200 cells/μL, increased viral load and coinfections or opportunistic infections. Antiviral therapy (ART) shows a beneficial effect, reducing the frequencies of thrombocytopenia and anemia, except in a zidovudine-based ART regimen, which worsens the anemic condition. Because anemia and thrombocytopenia are treatable comorbidities associated with increased mortality among PLWHA, physicians should monitor these risk factors in order to establish better interventions and reduce morbidity and mortality in PLWHA.
The Normative Grammar of Relational Analysis: Recognition Theory's Contribution to Understanding Short-Comings in IR's Relational Turn
Authors: Weber Martin 
Published: June 2020

AbstractThis Theory Note focuses on the resurgent interest in relationalism in constructivist IR theory. I begin by contextualizing current efforts to move constructivism toward this theoretical register. In particular, I focus on the framing influence of Mustafa Emirbayer's “Manifesto for a Relational Sociology,” showing how key theoretical concerns articulated there have resonated with the constructivist critique of rationalist and structuralist explanatory approaches in IR. These cross-purposes, however, also signal that the lacunae identified by Emirbayer should be of interest to IR constructivists seeking to promote a relationalist research project. I argue that in particular Emirbayer's identification of a gap on normative implications has not received adequate attention in IR debates. In the second part, I discuss Honneth's recognition theoretic approach as promising for supplementing a normative register that satisfies the “process-ontological” proclivities of relationalism as understood by IR constructivists. In the final part, I outline by way of an example some of the meta-theoretical and methodological implications of this version of recognition theory, contrast it with contending arguments in current debates, and commend its potential.
Quality of Glucosamine Products: Is it a Potential Reason for Inconsistent Clinical Outcomes in Osteoarthritis?
Authors: Asthana Chhavi , Peterson Gregory M , Shastri Madhur D , Patel Rahul P 
Published: June 2020

Abstract

Background
Clinical studies have reported inconsistent outcomes of glucosamine therapy in osteoarthritis patients. One possible reason could be the use of glucosamine products of varying quality.

Objective
Hence, this study aimed to assess the quality of glucosamine products marketed in Australia and India. This is the first study to investigate both the content and dissolution profiles of glucosamine products.

Method
The content and dissolution analysis of Australian (n = 25 brands) and Indian (n = 21 brands) glucosamine products was performed according to the criteria specified in the United States Pharmacopoeia (USP).

Results
The quality analysis revealed that 16% and 18% of Australian brands, as well as 24% and 19% of Indian brands, did not fulfil the USP content and dissolution criteria, respectively. In approximately half of these cases, the glucosamine content was only slightly below (&lt;3%) that specified by the USP and dissolution was achieved within 15 min after the duration specified by the USP.

Conclusions
The majority of the brands did meet both the content and dissolution analysis criteria of the USP. The extent of deviation from the specified criteria for the other brands was probably insufficient to account for the significant variability in clinical effects. Hence, the study proposed that inter-patient pharmacokinetic variations in glucosamine could be another potential reason for inconsistent therapeutic effects.

Highlights
Development and Validation of an LC–MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction
Authors: Sofalvi Szabolcs , Lavins Eric S , Kaspar Claire K , Michel Haley M , Mitchell-Mata Christie L , Huestis Marilyn A , Apollonio Luigino G 
Published: June 2020

Abstract
An analytical method for the detection of 40 benzodiazepines, (±)-zopiclone, zaleplon and zolpidem in blood and urine by solid-phase extraction liquid chromatography–tandem mass spectrometry was developed and validated. Twenty-nine of 43 analytes were quantified in 0.5 mL whole blood for investigating postmortem, drug-facilitated sexual assault (DFSA) and driving under the influence of drugs cases (DUID). The four different dynamic ranges of the seven-point, linear, 1/x weighted calibration curves with lower limits of quantification of 2, 5, 10 and 20 μg/L across the analytes encompassed the majority of our casework encountered in postmortem, DFSA and DUID samples. Reference materials were available for all analytes except α-hydroxyflualprazolam, a hydroxylated metabolite of flualprazolam. The fragmentation of α-hydroxyflualprazolam was predicted from the fragmentation pattern of α-hydroxyalprazolam, and the appropriate transitions were added to the method to enable monitoring for this analyte. Urine samples were hydrolyzed at 55°C for 30 min with a genetically modified β-glucuronidase enzyme, which resulted in &gt;95% efficiency measured by oxazepam glucuronide. Extensive sample preparation included combining osmotic lysing and protein precipitation with methanol/acetonitrile mixture followed by freezing and centrifugation resulted in exceptionally high signal-to-noise ratios. Bias and between-and within-day imprecision for quality controls (QCs) were all within ±15%, except for clonazolam and etizolam that were within ±20%. All 29 of the 43 analytes tested for QC performance met quantitative reporting criteria within the dynamic ranges of the calibration curves, and 14 analytes, present only in the calibrator solution, were qualitatively reported. Twenty-five analytes met all quantitative reporting criteria including dilution integrity. The ability to analyze quantitative blood and qualitative urine samples in the same batch is one of the most useful elements of this procedure. This sensitive, specific and robust analytical method was routinely employed in the analysis of &gt;300 samples in our laboratory over the last 6 months.
An unusual combination of persistent silent truncus arteriosus Type-II with ascending aortic aneurysm
Authors: Yusuf Mohamud Mohamed Farah , Mohamud Mohamed Abdullahi , Hussein Abdinafic Mohamud , İbrahim Ismail Gedi 
Published: June 2020

Abstract
Truncus arteriosus (TA) is a relatively uncommon cyanotic congenital cardiac anomaly accounting for 1.3% of all congenital cardiac malformations. TA associated with an ascending aortic aneurysm is an extremely rare congenital cardiovascular abnormality. A 15-year-old male presented with shortness of breath and cough for 2 weeks. Radiological examinations showed that the ascending aorta and main pulmonary arteries originate from a single truncus with ascending aortic aneurysm. TA has a poor prognosis if remain unrepaired and surgical intervention is necessary to avoid severe pulmonary vascular occlusive disease.
The chemical nature of the young 120-Myr-old nearby Pisces–Eridanus stellar stream flowing through the Galactic disc
Authors: Hawkins Keith , Lucey Madeline , Curtis Jason 
Published: June 2020

ABSTRACT
Recently, a new cylindrical-shaped stream of stars up to 700 pc long was discovered hiding in the Galactic disc using kinematic data enabled by the Gaia mission. This stream of stars, dubbed Pisces–Eridanus (Psc–Eri), was initially thought to be as old as 1 Gyr, yet its stars shared a rotation period distribution consistent with a population that was 120 Myr old. Here, we explore the detailed chemical nature of this stellar stream. We carried out high-resolution spectroscopic follow-up of 42 Psc–Eri stars using McDonald Observatory and combined these data with information for 40 members observed with the low-resolution LAMOST spectroscopic survey. Together, these data enabled us to measure the abundance distribution of light/odd-Z (Li, Na, Al, Sc, V), α (Mg, Si, Ca, Ti), Fe-peak (Cr, Mn, Fe, Co, Ni, Zn), and neutron capture (Sr, Y, Zr, Ba, La, Nd, Eu) elements along the Psc–Eri stream. We find that the stream is (1) near-solar metallicity with [Fe/H] = –0.03 dex and (2) has a metallicity spread of 0.07 dex (or 0.04 dex when outliers are excluded). We also find that (3) the abundance of Li indicates that Psc–Eri is ∼120 Myr old, consistent with its gyrochronology age. Additionally, Psc–Eri has (4) [X/Fe] abundance spreads that are just larger than the typical uncertainty in most elements, (5) it is a cylindrical-like system whose outer edges rotate about the centre, and (6) no significant abundance gradients along its major axis except a potentially weak gradient in [Si/Fe]. These results show that Psc–Eri is a uniquely close young chemically interesting laboratory for testing our understanding of star and planet formation.
Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast
Authors: Nguyen Duong T , Wu Baojun , Long Hongan , Zhang Nan , Patterson Caitlyn , Simpson Stephen , Morris Krystalynne , Thomas W Kelley , Lynch Michael , Hao Weilong 
Published: June 2020

AbstractMutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial variation in mutation rates and mutation spectra. We also observed high LOH rates (1.65–11.07×10−6 events per heterozygous site per cell division). Biases in spontaneous mutation and LOH together with selection ultimately shape the variable genome-wide nucleotide landscape in yeast species.
Structure-guided DNA–DNA attraction mediated by divalent cations
Authors: Srivastava Amit , Timsina Raju , Heo Seung , Dewage Sajeewa W , Kirmizialtin Serdal , Qiu Xiangyun 
Published: June 2020

Abstract
Probing the role of surface structure in electrostatic interactions, we report the first observation of sequence-dependent dsDNA condensation by divalent alkaline earth metal cations. Disparate behaviors were found between two repeating sequences with 100% AT content, a poly(A)-poly(T) duplex (AA-TT) and a poly(AT)-poly(TA) duplex (AT-TA). While AT-TA exhibits non-distinguishable behaviors from random-sequence genomic DNA, AA-TT condenses in all alkaline earth metal ions. We characterized these interactions experimentally and investigated the underlying principles using computer simulations. Both experiments and simulations demonstrate that AA-TT condensation is driven by non-specific ion–DNA interactions. Detailed analyses reveal sequence-enhanced major groove binding (SEGB) of point-charged alkali ions as the major difference between AA-TT and AT-TA, which originates from the continuous and close stacking of nucleobase partial charges. These SEGB cations elicit attraction via spatial juxtaposition with the phosphate backbone of neighboring helices, resulting in an azimuthal angular shift between apposing helices. Our study thus presents a distinct mechanism in which, sequence-directed surface motifs act with cations non-specifically to enact sequence-dependent behaviors. This physical insight allows a renewed understanding of the role of repeating sequences in genome organization and regulation and offers a facile approach for DNA technology to control the assembly process of nanostructures.