bluuebunny/crossref_metadata_2025_split huggingface dataset:
JUNTS framework for creating web apps to bridge the gap in doctor-patient communication: the case of COMjuntos application in the field of rare diseases
Authors: Bagò Rosa Estopà i , Ruiz Manuel Armayones 
Published: July 2020

Abstract
Background. The diagnosis or even the suspicion of a disease on their children has an emotional impact on their parents and generates a need to acquire relevant knowledge and skills in a short period of time. For a range of motives, these parents will sometimes face communicative and cognitive barriers in their communication with the professionals that care for their children. These barriers can have a negative effect on knowledge acquisition, treatment adherence and, more generally, affect their relationship with clinicians. To overcome these barriers, we developed JUNTS framework following three steps: carrying out 10 semi-structured interviews with parents of child’s affected by a rare disease. Secondly, we carried out interviews with health professionals and patient’s organization staff. The third and last steep was to organize a meeting of the whole research team and patient’s association staff of Spanish Federation of Rare Disease and list a set of design trends that could help parents to solve the main communicational and linguistic barriers.Results. The JUNTS Framework presented here helps parents manage the communicative situations they find themselves in the relationship with health professionals, by exploiting a polyphonic design that includes different levels of involvement. One of the characteristics that makes this approach particularly unique is that parents and representatives of patient-support associations work jointly with health professionals, psychologists and language experts in designing the contents of a parents-support application. The Framework exploits a modular structure centred around a series of short challenges with different types of user involvement (visual, textual and hypertextual). For optimal adherence and to ensure patients complete the whole route through the support material, elements of persuasive design have been integrated.Conclusions. In this paper, we outline how the JUNTS framework has been designed and used to develop the web app COMjuntos based in JUNTS framework. This web app facilitates medical communication and has been specifically designed to help parents who have a child with a rare disease empower themselves in the main communicative situations with health professionals. The JUNTS framework can be adapted to any other type of chronic disease or condition.
Metaphase spreads of human oocytes
Authors: Gruhn Jennifer R. , Newnham Louise J. , Hoffmann Eva R. 
Published: July 2020

Abstract
This protocol outlines the generation of metaphase spreads of a single oocyte at either the immature metaphase I (MI) or mature metaphase II (MII) stage. This protocol utilizes formaldehyde fixation and therefore allows for further immunofluorescence analysis. These spreads can also be used to identify aneuploidy and other large-scale structural chromosomal abnormalities. However, this assay is prone to false positives for whole chromosome aneuploidy losses, due to either fixation failure or excessive spreading leading to an inability to find all the chromosomes. Additionally, success rates can be low using human oocytes compared to similar protocols for mouse oocytes due to difficulty bursting the oocyte membrane and providing sufficient dispersion of the chromosomes for individual analysis. The protocol duration is two days, however, immunofluorescence staining will add to the total time before final analysis.
Determinants and impact of role-related time use allocation on self-reported health among married men and women: a cross-national comparative study
Authors: Jonsson Kenisha Russell , Oberg Gustav , Samkange-Zeeb Florence , Adjei Nicholas Kofi 
Published: July 2020

Abstract
Background: Research on the effects of marriage on health maintains that there is a gender-specific gradient, with men deriving far greater benefits than women. One reason provided for this difference is the disproportionate amount of time spent by women on housework and childcare. However, this hypothesis has yet to be explicitly tested for these role-related time use activities. This study provides empirical evidence on the association between role-related time use activities (i.e. housework, childcare and paid work) and self-reported health among married men and women. Methods: Data from the Multinational Time Use Study (MTUS) on 32,881 men and 26,915 women from Germany, Italy, Spain, the UK and the US were analyzed. Seemingly unrelated regression (SUR) models and multivariable logistic regression were used to estimate the association between role-related time use activities and self-reported health among married men and women. Results: The findings showed that education, occupation and number of children in the household under 18 years old were the most consistent predictors of time allocation among married men and women. Significant gender differences were also found in time allocation, with women sacrificing paid working time or reducing time devoted to housework for childcare. Men, in contrast, were less likely to reduce paid working hours to increase time spent on childcare, but instead reduced time allocation to housework. Allocating more time to paid work and childcare was associated with good health, whereas time spent on housework was associated with poor health, especially among women. Conclusions: Time allocation to role-related activities have differential associations on health, and the effects vary by gender and across countries. To reduce the gender health gap among married men and women, public policies need to take social and gender roles into account.
Economic incentives and survival probabilities for chronic and multimorbidity patients - Do the relationships depend on patient pathways?
Authors: Islam M. Kamrul , Kjerstad Egil , Askildsen Jan Erik 
Published: July 2020

Abstract
Background: The Norwegian Coordination Reform (CR) in 2012 introduced new economic incentives aimed at weaknesses in interaction between primary care, social care and specialist care. This paper studies the association of a new co-payment scheme on the 30-day and 90-day survival probabilities for chronic and multimorbidity patients. We also analyse whether admission types ⸺ planned or emergency ⸺ matters for survival rates, and the importance of patient pathways. Several different pathways are possible, depending on where patients came from before being admitted to hospital and their destination after discharge from hospital. Methods: The study uses data from three different registers for the period 2010 to 2013. We consider 30 common chronic conditions for which administrative data are available (n=563,096 in-patient episodes). We look at three mutually exclusive pathways. They are relevant and important in terms of the number of patients depending on co-operation and co-ordination between health care providers. Using a quasi-experimental design—the difference-in-differences approach—we estimate the associations between the co-payment scheme and survival probability by admission type and by patient pathway. Results: We find that the change in survival probabilities are significant and positively associated with the co-payment scheme for emergency admissions, but no significant association is found for planned admissions for the 30-day survival. A positive and significant relationship is also found for emergency patients for two specific pathways. For planned admissions, the survival probabilities are significantly and negatively associated for patients coming from home and later discharged to social care institutions. Multimorbidity subgroup analysis shows that the positive (negative) association with the 90-day (30-day) survival is significant only for emergency (planned) admissions for the patients coming from home and later discharged to home or social care after in-patient hospitalization. Conclusion: We conclude that the survival probabilities are positively associated with the new economic incentives but the result depends on admission type, patient pathway and multimorbidity status. Without modelling admission type, pathway and multimorbidity explicitly, one may overlook important relationships associated with the economic incentives. Future policy evaluations in any pertinent context should envisage these aspects.
Healthcare utilisation and out-of-pocket expenditure of type 2 diabetes patients with and without comorbidity: A study in primary care in Bhubaneswar, India.
Authors: Pati Sandipana , Swain Subhashisa , Akker Marjan van den , Schellevis F. (François) G. , Burgers Jako S. 
Published: July 2020

Abstract
Background: Globally, non-communicable diseases (NCD) demand a higher healthcare expenditure. Amongst the NCDs, diabetes mellitus, is often associated with multiple, co-existing chronic conditions. In low- and middle-income countries where most of the healthcare expenditure is borne out of pocket, diabetes management may pose a significant financial stress.Methods: A cross-sectional study was conducted in 17 urban primary healthcare facilities of Bhubaneswar to assess the healthcare utilisation and out-of-pocket expenditure among type 2 diabetes patients attending these facilities. Healthcare utilisation was determined by the number of visits to healthcare facilities in the last six months, and out-of-pocket expenditure was assessed by outpatient consultation fees, medicines, travels to health care facilities and diagnostic tests. Total out-of-pocket expenditure was defined as the sum of these costs.Results: The median number of visits in 6 months for diabetes patients with any comorbidity was 4 and 5 for diabetes patients with more than 4 comorbidities. Among the comorbid conditions, depression, stroke, auditory impairment and acid peptic disease were associated with higher healthcare utilisation. The total out-of-pocket expense was 2.3 times higher among diabetes patients with any comorbid condition compared to patients with diabetes only. The total median expenditure was higher for diabetes patients having stroke, heart diseases, kidney diseases and cancer compared to other comorbid conditions. The association of comorbidity in diabetes patients with health care utilization and out-of-pocket expenditure is statistically significant after adjustment for sociodemographic characteristics and diabetes duration.Conclusion: Considerable expenditure is incurred by diabetes patients attending primary healthcare facilities for the management of diabetes and other chronic conditions. This is a significant burden for diabetes patients below the poverty line and with limited or no insurance cover. There is a need to increase the coverage of insurance schemes to address the chronic conditions management expenditure of outpatients.
The prognostic factors in sepsis patients after operation of gastrointestinal tumors in ICU
Authors: Chen Ren-Xiong , Wu Zhou-Qiao , Li Zi-Yu , Wang Hong-Zhi , Ji Jia-Fu 
Published: July 2020

Abstract
Objectives: We studied the clinical profiles and the prognostic factors in patients with sepsis after thegastrointestinal tumor surgery in ICU.Methods: We retrospectively screened patients who underwent the gastrointestinal tumor surgery at the Peking University Cancer Hospital from January 2015 to December 2019. Among them, 181 patients who were diagnosed with sepsis in ICU were enrolled in our study. Cox regression was performed for multivariate adjusted factor analyses.Results: The 90-day all-cause mortality rate was 11.1% in our study. The univariate analysis showed that BMI, shock within 48h after entering ICU, number of blood leukocytes, the ratio of lymphocytes to neutrophils, INR, creatinine, procalcitonin, lactic acid, oxygenation index, SOFA score within 24h after entering ICU, APACHE II score within 24h after entering ICU were statistically significant. In multiple analysis, we found that BMI＞20kg/m2 was a protective factor, while lactic acid＞3 mmol/L after entering ICU and APACHE II score＞20 within 24h after entering ICU were independent risk factors for the prognosis of sepsis after the gastrointestinal tumor surgery in ICU. Conclusions: The 90-day all-cause mortality rate was 11.1% in our study. BMI＞20kg/m2 was a protective factor, while lactic acid＞3 mmol/L after entering ICU and APACHE II score＞20 within 24h after entering ICU were independent risk factors for the prognosis of sepsis after the gastrointestinal tumor surgery in ICU.
Presence of MTHFR Polymorphisms and the Levels of Folic Acid and Homocysteine in Women Enrolled in an Assisted Reproductive Program
Authors: Morales Felipe Arturo , Ruiz Martha Merino , Briseño José A. Elizondo , Garza Laura E. Martínez , Gutiérrez Oscar Vidal , Hernández Luis H. Sordia 
Published: July 2020

Abstract
Purpose: Folic acid and homocysteine levels are influenced by the circulating levels of estradiol. Little is known about the behavior of these metabolites during an in vitro fertilization cycle, where superovulation protocols induce a major increased in the levels of estradiol and other hormones. Methods: We performed a prospective, comparative, transversal, descriptive and observational study that includes 49 cases (group A), which were patients that entered a fertility program, and 14 controls (group B), which correspond to the donor group. In both groups, the levels of folic acid, estradiol and homocysteine as well as the MTHFR polymorphism were determined. Results: None of the patients has subnormal levels of folic acid or homocysteine and these levels were not modified after ovarian stimulation. We observed that homocysteine concentration tended to decrease with elevated estradiol levels produced by the stimulation of the ovary. The presence of allele C677T MTHFR was high in the populations evaluated in this study, with a particular high incidence of the TT allele. Conclusion: The levels of plasma and intracellular folate, and homocysteine do not change during hormonal stimulation.
Systematic Evaluation of Implemented Strategic Trypanosomosis and Vector control activities by the Application of Insecticides (Deltamethrin base) using Stationary attractive devices (targets), Ground sprays and Live bait techniques in upper Birbir valley, Ethiopia
Authors: Meharenet Behablom , Desta Tekalegn , Shitu Dessalew , Tsegaye Mintesnot 
Published: July 2020

Abstract
Background

Trypanosomosis and vector control methods have evolved from game animal destruction and bush clearing, which mainly targeted on the removal of the source of food and shade, to insecticide spraying following the discovery of DDT. Baseline and control entomological and parasitological surveys or studies were carried out from September 2016 to February 2018, with the purpose intended to systematically evaluate the effectiveness of implemented strategic trypanosomosis and vector control activities.
Results

Baseline and control entomological surveys or studies were compared; and an overall apparent fly density of 2.61 flies/trap/day during the baseline survey was declined to 1.68 flies/trap/day with the rate of 64.37% after control with supporting evidence of a decrease in the daily mean catch of fly per single trap from 5.23 ± 1.58 to 3.35 ± 1.58, (Mean catch ± SD). Based on baseline and control survey or study results the overall prevalence of bovine trypanosomosis was compared and significantly declined from 7.91–4.81%, likelihood-ratio = 13.49, Pr = 0.000, with the rate of 60.81%. Furthermore, significantly better heard mean packed cell volume was observed during control survey or study 22.53 ± 4.48, 25.68 ± 4.04 (Mean PCV ± SD), when compared with baseline 21.87 ± 4.57, 25.41 ± 4.27 (Mean PCV ± SD), in parasite-infected and non- infected cattle respectively.
Conclusions

The study concluded that the use of stationary attractive devices (targets), Ground sprays, and Live bait techniques of Deltamethrin based insecticide had shown a significant decline in the density of tsetse fly (vector hosts) and trypanosomosis prevalence with a better heard mean PCV of infected and non-infected cattle. Therefore, the research recommended that such kind of control methods which are environmentally friendly or non-intrusive, cheap, and non-complicated for farmers and experts living at endemic tsetse belt areas.
Investigation on the Mental Health Status and Risk Factors Among Chinese Overseas Students Under COVID-19 Outbreak
Authors: Anan Cong , Chunfeng Xiao , Shuxin Luan , Lirui Kang , Jingjing Yuan , Chang Liu 
Published: July 2020

Abstract
Background Corona Virus Disease (COVID-19) caused by SARS‐CoV‐2 had caused a global pandemic. According to incomplete statistics, at least 400,000 of Chinese overseas students were now staying abroad during the COVID-19 epidemic. Under the condition of extensive isolation, the social support system was also impacted, all this will lead to various kinds of psychological problems. However, there are no studies on the psychological problems of Chinese overseas students during the epidemic at home and abroad. ObjectivesTo investigate the mental health status and its risk factors among Chinese overseas students during the COVID-19 pandemic. Methods We conducted a cross-sectional survey based on structured questionnaire through various social platforms (WeChat, QQ, etc.). The contents of the structured questionnaire included: demographic characteristics, 9-item Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder 7-item Scale (GAD-7) and 15-item Patient Health Questionnaire (PHQ-15). Results ① The incidence rates of depression, anxiety and physical symptoms were 60.3%, 53.2% and 83.3%, respectively. ② There were significant statistical differences in the incidence rates of depression, anxiety and physical symptoms between different genders (depression: x2= 148.94, P=0.000; anxiety: x2=129.45, P=0.000; physical symptoms: x2=62.73, P=0.000). Significant statistical differences were also found in the incidence rates of depression and anxiety among different education levels (depression: x2=10.82, P=0.013; anxiety: x2=9.09, P=0.028). Additionally, there were significant statistical differences in the incidence rates of depression (x2=12.77, P=0.005) among different ages, and time of daily attention to epidemic-related information were closely associated with physical symptoms (x2=12.14, P=0.007). ③Logistic regression analysis showed that the female have a higher risk of developing depression [OR=0.017, 95% CI: 0.008~0.037, P=0.000], anxiety [OR=0.024, 95% CI: 0.011~0.051, P=0.000] and physical symptoms [OR=0.018, 95%CI: 0.004~0.078, P=0.000], and time of daily attention to epidemic-related information was positively associated with the level of physical symptoms [OR=0.610, 95% CI: 0.415~0.895, P=0.012]. Conclusion During the COVID-19 epidemic, Chinese overseas students were highly susceptible to a series of psychological and mental problems, including depression, anxiety and physical symptoms, and have a relatively higher risk than other populations. The purpose of this study is to call on relevant departments to pay attention to the psychological problems of this special group and propose effective prevention and control measures to ensure the mental health of the masses during the epidemic and promote the scientific development of mental health work.
The Effect of Retail Electricity Price Levels on the Financial Indicators of Smart-Grid Rooftop Solar Power Systems: A Case Study in the Central Highlands of Vietnam
Authors: Lan Tran Thi , Jirakiattikul Sopin , Le Niem Duc , Chowdhury M. S. , Ali Dilawer , Techato Kuaanan 
Published: July 2020

Abstract
Background: There are many constraints on the use of fossil fuels and, many countries have, therefore, conducted research relating to alternative energy resources to replace conventional fuels. On 31 January 2019, the Vietnamese Ministry of Finance enacted a preferential policy relating to the installation of under-50kWp rooftop solar projects. The Central Highlands of Vietnam has a high potential for solar power generation due to the duration of sunshine it enjoys, and the development of both rooftops solar and solar farms is appropriate for the region. The study reported investigated the economic efficiency of smart-grid rooftop solar electricity systems (SG rooftop PV) in the Central Highlands of Vietnam in light of the different levels of retail electricity pricing in Vietnam and the implementation of a feed-in-tariff system. The research reported in this paper will be useful for many groups of stakeholders, including electricity consumers who intend to install rooftop solar panels on their houses, companies who supply SG rooftop PV, and policymakers, who can use the findings relating to SG rooftop PV to adjust the retail price of electricity during different periods.Method: Financial indicators were calculated based on the net present value, payback period, internal rate of return, and the number of hours of sunshine in the Central Highlands of VietnamResult: The study’s results show that the electricity price level affects the economic efficiency of SG rooftop PV. In particular, SG rooftop PV installed to satisfy higher levels of electricity consumption, which attract a higher retail electricity price, result in greater benefits, especially when domestic electricity consumption exceeds 400 kWh, at which level the retail electricity price is at the highest level. In this case, people who install SG rooftop PV and use all the electricity to satisfy domestic consumption will recoup their investment in only 4 years and thereafter will enjoy free electricity. Conclusion: All the financial indicators derived from this research show that people in the Central Highlands of Vietnam can derive benefit from installing SG rooftop PV, whether they sell all the electricity output to the grid or use the power output to satisfy their domestic demand.