bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hints of radio sources evolution
Authors: Cassaro Pietro 
Published: April 2020

AbstractAn understanding of the mechanisms that regulate the Active Galactic Nuclei passes through the study of their early life stages, observable in Compact Symmetric Objects. To this purpose, a study was carried out on two compact radio sources, based on data from the VLBA archive at different times and frequencies. The results are compatible with an intermediate scenario between the two main theories about these objects: frustration and youth.
On the prospects of imaging Sagittarius A* from space
Authors: Roelofs Freek , Falcke Heino , Brinkerink Christiaan , Moscibrodzka Monika , Gurvits Leonid I. , Martin-Neira Manuel , Kudriashov Volodymyr , Klein-Wolt Marc , Tilanus Remo , Kramer Michael , Rezzolla Luciano 
Published: April 2020

AbstractVery Long Baseline Interferometry (VLBI) at sub-millimeter waves has the potential to image the shadow of the black hole in the Galactic Center, Sagittarius A* (Sgr A*), and thereby test basic predictions of the theory of general relativity. We investigate the imaging prospects of a new Space VLBI mission concept. The setup consists of two satellites in polar or equatorial circular Medium-Earth Orbits with slightly different radii, resulting in a dense spiral-shaped uv-coverage with long baselines, allowing for extremely high-resolution and high-fidelity imaging of radio sources. We simulate observations of a general relativistic magnetohydrodynamics model of Sgr A* for this configuration with noise calculated from model system parameters. After gridding the uv-plane and averaging visibilities accumulated over multiple months of integration, images of Sgr A* with a resolution of up to 4 μ as could be reconstructed, allowing for stronger tests of general relativity and accretion models than with ground-based VLBI.
Gamma-ray emission in radio galaxies, from MeV to TeV
Authors: Torresi Eleonora 
Published: April 2020

AbstractThanks to the Fermi λ-ray satellite and the current Imaging Atmospheric Cherenkov Telescopes, radio galaxies have arisen as a new class of high- and very-high energy emitters. The favourable orientation of their jets makes radio galaxies extremely relevant in addressing important issues such as: (i) revealing the jet structure complexity; (ii) localising the emitting region(s) of high- and very-high energy radiation; (iii) understanding the physical processes producing these photons. In this review the main results on the λ-ray emission studies of radio galaxies from the MeV to TeV regimes will be presented, and the impact of future Cherenkov Telescope Array observations will be discussed.
Progress in Simulating the Quasi‐Biennial Oscillation in CMIP Models
Authors: Richter Jadwiga H. , Anstey James A. , Butchart Neal , Kawatani Yoshio , Meehl Gerald A. , Osprey Scott , Simpson Isla R. 
Published: April 2020

AbstractThe quasi‐biennial oscillation (QBO) of the zonal mean zonal wind is the primary mode of variability in the tropical lower stratosphere. The QBO is characterized by alternating easterly westerly shear layers that descend down from ∼10 to 100 hPa. The QBO is also seen in lower stratospheric tropical temperature, water vapor, and ozone and affects tropospheric variability through various teleconnections. We examine here the progress in simulating the QBO in the Coupled Model Intercomparison Project (CMIP) models, more specifically in CMIP3, CMIP5, and CMIP6 models. We show that the number of models that are able to simulate the QBO has increased from 0 in CMIP3, to 5 in CMIP5, to 15 in CMIP6. While the number of models with an internally generated QBO has tripled from CMIP5 to CMIP6, the fidelity of the simulation averaged over the CMIP models has not improved. We show that CMIP5 and CMIP6 models represent the QBO period and latitudinal extent quite well; however the QBO amplitude is shifted upwards relative to observations resulting in large underestimation of QBO amplitude at all levels below 20 hPa. The underestimation of QBO amplitude in the lowermost stratosphere and lack of variations downward to the tropopause and below will likely impact the quality of teleconnections seen in the current generation Earth system models.
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
Authors: Tomasovic Angela , Brand Theresa , Schanbacher Constanze , Kramer Sofia , Hümmert Martin W. , Godoy Patricio , Schmidt-Heck Wolfgang , Nordbeck Peter , Ludwig Jonas , Homann Susanne , Wiegering Armin , Shaykhutdinov Timur , Kratz Christoph , Knüchel Ruth , Müller-Hermelink Hans-Konrad , Rosenwald Andreas , Frey Norbert , Eichler Jutta , Dobrev Dobromir , El-Armouche Ali , Hengstler Jan G. , Müller Oliver J. , Hinrichs Karsten , Cuello Friederike , Zernecke Alma , Lorenz Kristina 
Published: April 2020

AbstractDysregulation of extracellular signal-regulated kinases (ERK1/2) is linked to several diseases including heart failure, genetic syndromes and cancer. Inhibition of ERK1/2, however, can cause severe cardiac side-effects, precluding its wide therapeutic application. ERKT188-autophosphorylation was identified to cause pathological cardiac hypertrophy. Here we report that interference with ERK-dimerization, a prerequisite for ERKT188-phosphorylation, minimizes cardiac hypertrophy without inducing cardiac adverse effects: an ERK-dimerization inhibitory peptide (EDI) prevents ERKT188-phosphorylation, nuclear ERK1/2-signaling and cardiomyocyte hypertrophy, protecting from pressure-overload-induced heart failure in mice whilst preserving ERK1/2-activity and cytosolic survival signaling. We also examine this alternative ERK1/2-targeting strategy in cancer: indeed, ERKT188-phosphorylation is strongly upregulated in cancer and EDI efficiently suppresses cancer cell proliferation without causing cardiotoxicity. This powerful cardio-safe strategy of interfering with ERK-dimerization thus combats pathological ERK1/2-signaling in heart and cancer, and may potentially expand therapeutic options for ERK1/2-related diseases, such as heart failure and genetic syndromes.
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
Authors: An Juan Ji , Kinney Clint E. , Tan Ji-Wei , Liao Guey-Ying , Kremer Eric J. , Xu Baoji 
Published: April 2020

AbstractThe TrkB receptor is critical for the control of energy balance, as mutations in its gene (NTRK2) lead to hyperphagia and severe obesity. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remains unknown. Here, we demonstrate that selective Ntrk2 deletion within paraventricular hypothalamus (PVH) leads to severe hyperphagic obesity. Furthermore, chemogenetic activation or inhibition of TrkB-expressing PVH (PVHTrkB) neurons suppresses or increases food intake, respectively. PVHTrkB neurons project to multiple brain regions, including ventromedial hypothalamus (VMH) and lateral parabrachial nucleus (LPBN). We find that PVHTrkB neurons projecting to LPBN are distinct from those to VMH, yet Ntrk2 deletion in PVH neurons projecting to either VMH or LPBN results in hyperphagia and obesity. Additionally, TrkB activation with BDNF increases firing of these PVH neurons. Therefore, TrkB signaling is a key regulator of a previously uncharacterized neuronal population within the PVH that impinges upon multiple circuits to govern appetite.
Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
Authors: Tajima Kazuki , Ikeda Kenji , Tanabe Yuji , Thomson Ella A. , Yoneshiro Takeshi , Oguri Yasuo , Ferro Marc D. , Poon Ada S. Y. , Kajimura Shingo 
Published: April 2020

AbstractCold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure. However, systemic activation of the β3-AR pathway inevitably increases blood pressure, a significant risk factor for cardiovascular disease, and, thus, limits its application for the treatment of obesity. To activate fat thermogenesis under tight spatiotemporal control without external stimuli, here, we report an implantable wireless optogenetic device that bypasses the β-AR pathway and triggers Ca2+ cycling selectively in adipocytes. The wireless optogenetics stimulation in the subcutaneous adipose tissue potently activates Ca2+ cycling fat thermogenesis and increases whole-body energy expenditure without cold stimuli. Significantly, the light-induced fat thermogenesis was sufficient to protect mice from diet-induced body-weight gain. The present study provides the first proof-of-concept that fat-specific cold mimetics via activating non-canonical thermogenesis protect against obesity.
Gene silencing of Diaphorina citri candidate effectors promotes changes in feeding behaviors
Authors: Pacheco Inaiara de Souza , Galdeano Diogo Manzano , Maluta Nathalie Kristine Prado , Lopes Joao Roberto Spotti , Machado Marcos Antonio 
Published: April 2020

AbstractInsect effectors are mainly secreted by salivary glands, modulate plant physiology and favor the establishment and transmission of pathogens. Feeding is the principal vehicle of transmission of Candidatus Liberibacter asiaticus (Ca. Las) by the Asian citrus psyllid (ACP), Diaphorina citri. This study aimed to predict putative ACP effectors that may act on the Huanglongbing (HLB) pathosystem. Bioinformatics analysis led to the identification of 131 candidate effectors. Gene expression investigations were performed to select genes that were overexpressed in the ACP head and modulated by Ca. Las. To evaluate the actions of candidate effectors on D. citri feeding, six effectors were selected for gene silencing bioassays. Double-stranded RNAs (dsRNAs) of the target genes were delivered to D. citri adults via artificial diets for five days. RNAi silencing caused a reduction in the ACP lifespan and decreased the salivary sheath size and honeydew production. Moreover, after dsRNA delivery of the target genes using artificial diet, the feeding behaviors of the insects were evaluated on young leaves from citrus seedlings. These analyses proved that knockdown of D. citri effectors also interfered with ACP feeding abilities in planta, causing a decrease in honeydew production and reducing ACP survival. Electrical penetration graph (EPG) analysis confirmed the actions of the effectors on D. citri feeding behaviors. These results indicate that gene silencing of D. citri effectors may cause changes in D. citri feeding behaviors and could potentially be used for ACP control.
Teriparatide Associated with Fewer Refractures and Higher Body Heights of Cemented Vertebrae after Vertebroplasty: A Matched Cohort Study
Authors: Yang Yi-Shan , Tsou Yi-Syue , Lo Wen-Cheng , Chiang Yung-Hsiao , Lin Jiann-Her 
Published: April 2020

AbstractRefracture of cemented vertebrae occurs commonly after vertebroplasty (VP) for osteoporotic vertebral compression fracture (OVCF). It can result in severe pain or neurological deficit, but no preventive medication is available. Owing to the bone anabolic benefits of teriparatide (TP), this study was aimed to compare the outcomes of cemented vertebrae with TP to those without TP. Patients who received VP for OVCF with at least 1 year follow-up were included. The anterior body height (ABH) and middle body height (MBH) and kyphotic angle (KA) were measured before VP and 1 week and at least 1 year after VP. Refracture was defined as a 15% decrease in ABH or MBH and 8° decrease in KA compared with those at postoperative 1 week. The clinical outcomes were evaluated. 35 VP procedures in 21 patients treated with TP (TP group), and, matched to that, 29 out of 133 patients treated with VP alone (VP group) were included. One year after VP, ABH and MBH were significantly greater, except KA, in the TP group (VP group vs. TP group: KA − 4.97° ± 12.1 vs. −2.85° ± 12.21°, p = 0.462, ABH 1.56 ± 0.48 cm vs. 1.84 ± 0.56 cm, p = 0.027, MBH 1.49 ± 0.39 cm vs. 1.73 ± 0.41 cm, p = 0.017). The refracture rates of KA, ABH, and MBH were significantly lower in the TP group (VP group vs. TP group: KA 42.11% vs.8.57%, p < 0.001; ABH 76.32% vs. 28.57%, p < 0.0001; MBH 76.32% vs. 28.57%, p < 0.0001). In single-level subgroup comparison, TP was associated with better improvement of pain VAS and better radiological outcomes. TP was associated with higher BHs and fewer refractures than VP alone, with comparable clinical outcomes 1 year after VP. TP may be associated with better improvement of pain VAS in those with single-level VP procedure. Higher BH was due to the better maintenance effect of TP.
Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex
Authors: Cho Jongwook , Ryu Seungjun , Lee Sunwoo , Kim Junsoo , Kim Hyoung-Ihl 
Published: April 2020

AbstractClozapine (CLZ) has been proposed as an agonist for Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), to replace Clozapine-N-oxide (CNO); however, there are no reliable guidelines for the use of CLZ for chemogenetic neuromodulation. We titrated the optimal dose of CLZ required to evoke changes in neural activity whilst avoiding off-target effects. We also performed [18F]Fluoro-deoxy-glucose micro positron emission tomography (FDG-microPET) scans to determine the global effect of CLZ-induced hM3D(Gq) DREADD activation in the rat brain. Our results show that low doses of CLZ (0.1 and 0.01 mg/kg) successfully induced neural responses without off-target effects. CLZ at 1 mg/kg evoked a stronger and longer-lasting neural response but produced off-target effects, observed as changes in locomotor behavior and FDG-microPET imaging. Unexpectedly, FDG-microPET imaging failed to demonstrate an increase in regional glucose metabolism in the stimulated cortex during CLZ chemogenetic neuromodulation. Therefore, caution should be used when interpreting FDG-PET images in the context of cortical chemogenetic activation.
DeepMicro: deep representation learning for disease prediction based on microbiome data
Authors: Oh Min , Zhang Liqing 
Published: April 2020

AbstractHuman microbiota plays a key role in human health and growing evidence supports the potential use of microbiome as a predictor of various diseases. However, the high-dimensionality of microbiome data, often in the order of hundreds of thousands, yet low sample sizes, poses great challenge for machine learning-based prediction algorithms. This imbalance induces the data to be highly sparse, preventing from learning a better prediction model. Also, there has been little work on deep learning applications to microbiome data with a rigorous evaluation scheme. To address these challenges, we propose DeepMicro, a deep representation learning framework allowing for an effective representation of microbiome profiles. DeepMicro successfully transforms high-dimensional microbiome data into a robust low-dimensional representation using various autoencoders and applies machine learning classification algorithms on the learned representation. In disease prediction, DeepMicro outperforms the current best approaches based on the strain-level marker profile in five different datasets. In addition, by significantly reducing the dimensionality of the marker profile, DeepMicro accelerates the model training and hyperparameter optimization procedure with 8X–30X speedup over the basic approach. DeepMicro is freely available at https://github.com/minoh0201/DeepMicro.
ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
Authors: Touyz Rhian M. , Li Hongliang , Delles Christian 
Published: April 2020

Abstract
Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Coronavirus Disease (COVID)-19. In recognition of the importance of ACE2 and to celebrate 20 years since its discovery, the journal will publish a focused issue on the basic science and (patho)physiological role of this multifunctional protein.
Using Computerized Language Analysis to Evaluate Grammatical Skills
Authors: Finestack Lizbeth H. , Rohwer Bobbi , Hilliard Lisa , Abbeduto Leonard 
Published: April 2020

Purpose
Conducting in-depth grammatical analyses based on language samples can be time consuming. Developmental Sentence Scoring (DSS) and the Index of Productive Syntax (IPSyn) analyses provide detailed information regarding the grammatical profiles of children and can be conducted using free computer-based software. Here, we provide a tutorial to support clinicians' use of computer-based analyses to aid diagnosis and develop and monitor treatment goals.

Method
We analyzed language samples of a 5-year-old with developmental language disorder and an adolescent with Down syndrome using computer-based software, Computerized Language Analysis. We focused on DSS and IPSyn analyses. The tutorial includes step-by-step procedures for conducting the analyses. We also illustrate how the analyses may be used to assist in diagnosis, develop treatment goals focused on grammatical targets, and monitor progress on these treatment goals.

Conclusion
Clinicians should consider using Computerized Language Analysis's IPSyn and DSS analyses to support grammatical language assessments used to aid diagnosis, develop treatment goals, and monitor progress on these treatment goals.

Supplemental Material

https://doi.org/10.23641/asha.12021141
Stammzellen in der Regenerativen Medizin – Translationale Hürden und Möglichkeiten zur Überwindung
Authors: Klietz Marie-Luise , Kückelhaus Maximilian , Kaiser Hans Wilhelm , Raschke Michael J. , Hirsch Tobias , Aitzetmüller Matthias 
Published: April 2020

ZusammenfassungDer Einsatz von mesenchymalen Stammzellen in der regenerativen Medizin wird immer populärer. Nichtsdestotrotz ist ihre Anwendung im klinischen Alltag noch immer limitiert. Zahlreiche ethische, rechtliche und translationale Probleme sowie Ungewissheit bzgl. der Sicherheit hemmen noch immer die Entstehung von entsprechenden Therapien aus vielversprechenden wissenschaftlichen Ansätzen.Diese Arbeit soll die Hauptprobleme bei der Translation von stammzellbasierten Therapien aus der Grundlagenforschung und Präklinik in den klinischen Alltag darstellen, sowie Ansätze aufzeigen, diese zu überwinden.
Clinical Applications of Contrast-Enhanced Thoracic Ultrasound (CETUS) Compared to Standard Reference Tests: A Systematic Review
Authors: Jacobsen Niels , Pietersen Pia Iben , Nolsoe Christian , Konge Lars , Graumann Ole , Laursen Christian Borbjerg 
Published: April 2020

Abstract
Introduction Contrast-enhanced ultrasound is utilized in an increasing array of medical fields, including thoracic medicine. However, the technique is still relatively new and only sporadically mentioned in current guidelines and recommendations. The aim of this systematic review is to provide a literature overview and to critically appraise the current clinical applications of contrast-enhanced thoracic ultrasound (CETUS).
Materials and Methods A systematic literature search using major electronic databases and in accordance with PRISMA guidelines was performed. Studies with a primary focus on CETUS of thoracic disorders compared to a standard reference test were included. The QUADAS-2 tool was used for quality assessment of the studies.
Results The search identified 43 articles: 1 randomized controlled study, 6 non-randomized controlled studies, 16 non-randomized non-controlled studies, 5 case series, 10 single case reports, and 5 animal studies. The overall risk of bias was judged to be high. Diagnostic accuracy measurements of noninvasive applications of CETUS were only reported in a few studies and they were too dissimilar for meta-analysis. Six studies compared CETUS-guided versus ultrasound-guided transthoracic needle biopsy of thoracic masses. They individually reported a significant increase in diagnostic accuracy in favor of CETUS guidance but were too heterogeneous for meta-analysis.
Conclusion The current literature on CETUS is overall heterogeneous with a few high evidence level studies, small study populations and a high risk of bias. CETUS-guided biopsy is the most frequent clinical application and increases diagnostic accuracy compared to ultrasound guidance by an average of 14.6 percentage points.
Providing Hearing Education and Resources for Underserved Populations (HEAR-UP) in our Local Neighborhoods
Authors: Coyan Kathleen Costigan , Mormer Elaine 
Published: April 2020

AbstractHealthcare services in the United States are difficult to access for at least 10% of our population. Moreover, hearing healthcare services, including hearing aids, are largely inaccessible even for those individuals who may have health insurance and access to healthcare. Humanitarian audiology has been recognized as a means of supplying hearing services and devices to underserved populations around the globe. However, little has been publicized about humanitarian audiology projects taking place in local communities within the United States. This article describes one such project that has been in place in Pittsburgh, PA, for the past 4 years. This service results from collaboration across a collection of healthcare, community service, charitable, and educational organizations. The resources necessary to create similarly sourced services in other U.S. locations are described. Challenges and solutions for this local form of humanitarian audiology are discussed.
Sublingual Atropine Sulfate Use for Sialorrhea in Pediatric Patients
Authors: Azapağası Ebru , Kendirli Tanıl , Perk Oktay , Kutluk Gültekin , Öz Tunçer Gökçen , Teber Serap , Çobanoğlu Nazan 
Published: April 2020

AbstractSialorrhea is a frequent problem and may lead to aspiration in patients with swallowing dysfunction. We aimed to assess the effectiveness and safety of sublingual atropine sulfate treatment in pediatric patients with sialorrhea. The medical records of patients who had received sublingual atropine sulfate between January 2015 and January 2016 were reviewed retrospectively. The demographic properties, diagnosis, invasive or noninvasive mechanical ventilation need, and the presence of tracheotomy were assessed. Response rates to sublingual atropine were measured using the Teacher Drooling Scale (TDS). Pre and post-treatment drooling scores were compared. Atropine sulfate ampoule was administered at 20 µg/kg/dose. Minimum dose was 0.25 mg, while maximum dose was 0.03 mg/kg.Thirty-five pediatric patients with sialorrhea who had received sublingual atropine sulfate were identified; however, TDS scores had been recorded in only 20 of them. The median age of the patients was 25 months (3–78 months; 7 girls, 13 boys). Sixteen (80%) patients were on invasive mechanical ventilation and seven (30%) had tracheotomy. Nineteen patients had a neurodevelopmental disorder and only one patient had oral and esophageal lesions due to corrosive material intake. The median TDS score prior to sublingual atropine sulfate treatment was 5, and it decreased to 3 on the second day of treatment, a change that was statistically significant (p < 0.001). No side effects were observed. Sublingual atropine sulfate is safe and effective in the short-term treatment of sialorrhea; however, randomized placebo controlled and long-term follow-up studies are necessary.