bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality improvement in neurocritical care: current state and looking to the future
Authors: Moheet Asma M. , Livesay Sarah L. 
Published: February 2020

Purpose of review
Neurocritical care has matured as a field and there is now a growing body of literature on the subject of quality improvement in neurocritically ill patients. This review will highlight major recent contributions in this field and discuss future directions.

Recent findings
Articles published in the past 18 months have evaluated neurocritical care unit staffing, structure, and disease-specific protocols including subarachnoid hemorrhage and severe traumatic brain injury management. An assessment of current quality improvement practices in neurocritical care was also conducted. A neurocritical care-specific metric bundle is being proposed.

Summary
The quality improvement movement is gaining momentum in neurocritical care with evaluation of general medical and surgical critical care quality improvement approaches in this specific patient population. Future work should focus on improving systems of neurocritical care delivery through iterative evaluation of structure, staffing, minimizing unnecessary variation, and evaluation of neurocritical care-specific metrics.
Kidney transplantation following uncontrolled donation after circulatory death
Authors: Summers Dominic M. , Pettigrew Gavin J. 
Published: February 2020

Purpose of review
The identification and utilization of kidneys from uncontrolled donation after circulatory death (uDCD) donors for transplantation may increase transplantation rates markedly. This article summarizes the latest international results from successful uDCD kidney transplant programmes and considers how such programmes may impact on the transplant waiting list.

Recent findings
The results of more than 1000 uDCD donor kidney transplants have been reported since 2007 from France and Spain. Estimates from France, Spain and Sweden suggest that effective utilization of the potential uDCD donor pool might increase donation rates by 25%. The main concern relating to uDCD kidney transplantation is the high incidence of primary nonfunction with the incidence of primary nonfunction reported as 7–8% even with careful donor selection and the use of normothermic regional perfusion at the time of organ recovery. Notwithstanding, reported 1- year graft survival figures are equivalent to those from expanded criteria donors (ECD) and 10-year graft survival of between 72 and 82% was reported in the two single-centre series with longest reported follow-up period.

Summary
Uncontrolled DCD kidney transplantation has been successfully implemented in several regions in France and Spain. Wider implementation of uDCD programmes would increase substantially the number of kidneys for transplantation, while maintaining acceptable transplant outcomes.
Current status of pediatric intestinal transplantation in the United States
Authors: Venick Robert S. , Duggan Emily , Whatley Jordan 
Published: February 2020

Purpose of review
The present review aims to describe in detail the characteristics, outcomes, and recent trends in the field of pediatric intestinal transplantation in the United States. It will examine the route cause and future implications of these developments. The review will draw from recent publications in the field, the Intestinal Transplant Registry, and contemporary data from large U.S. single centers.

Recent findings
More than 1500 pediatric intestinal transplants have been performed in the United States since 1985, however, over the past decade there have been fewer than 50 transplants/year nationwide. This trend is largely a result of stagnant long-term ITx outcomes and advancements in intestinal rehabilitation programs. Nationally the overall 1-year and 5-year graft survival are 68 and 50% respectively, whereas certain high-volume centers have experienced significantly better results. Sepsis is the leading cause of death following pediatric ITx, whereas rejection is the leading cause of graft loss. Chronic kidney disease and posttransplant lymphoproliferative disorder are significant and relatively prevalent long-term complications. The majority of pediatric ITx recipients receive T-cell depleting induction agents and are on Tacrolimus-based immunosuppression. Most recipient are off parenteral nutrition, but may require supplemental tube feeds. Many pediatric ITx recipients require special education, and in certain domains some report lower health related quality of life.

Summary
As intestinal rehabilitation has improved in the modern era, the volume of pediatric ITx in the United States has decreased. Although pediatric ITx results have room for improvement nationwide, successful outcomes have been reported at experienced American centers.
First Case of High-Level Azithromycin-Resistant Neisseria gonorrhoeae in North Carolina
Authors: Palavecino Elizabeth L. , Kilic Abdullah , Schmerer Matthew W. , Dobre-Buonya Oana , Toler Cindy , McNeil Candice J. 
Published: February 2020

Abstract
We report on the first high-level azithromycin-resistant Neisseria gonorrhoeae isolate (minimum inhibitory concentration, ≥256 μg/mL) in North Carolina isolated from a pharyngeal swab of a 33-year-old HIV-negative man who has sex with men. In addition, the isolate was found to be susceptible to cefixime, ceftriaxone, and penicillin and resistant to tetracycline. By whole-genome sequencing, the strain was assigned as MLST ST9363, NG-MAST ST5035, and a novel NG-STAR sequence type, ST1993.
Serious video games and virtual reality for prevention and neurorehabilitation of cognitive decline because of aging and neurodegeneration
Authors: Sokolov Arseny A. , Collignon Amélie , Bieler-Aeschlimann Mélanie 
Published: February 2020

Purpose of review
Cognitive decline because of aging and neurodegeneration has become increasingly prevalent. This calls for the implementation of efficacious, motivating, standardized and widely available cognitive interventions for the elderly. In this context, serious video games and virtual reality may represent promising approaches. Here, we review recent research on their potential for cognitive prevention and neurorehabilitation of age-related cognitive decline and mild cognitive impairment (MCI).

Recent findings
The majority of currently available data in this evolving domain lacks the methodological quality to draw reliable conclusions on the potential of novel technology for cognitive training in older people. However, single well designed randomized controlled trials have reported promising effects of cognitive interventions involving serious video games and virtual reality. The cognitive benefits of exergames promoting physical exercise with and without combined cognitive training remain unclear.

Summary
The immersion into stimulating and motivating environments along with training content based on neuroscientific and neuropsychological models may represent a significant advance as compared with conventional computerized cognitive training. Additional research with sound methodology including sufficient sample sizes, active control groups and meaningful outcome measures of everyday function is needed to elucidate the potential of serious video games and virtual reality in multifactorial neurorehabilitation of cognitive decline in aging and neurodegeneration.
Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection
Authors: Lin Wei , Hu Longfei , Zhang Yan , Ooi Joshua D. , Meng Ting , Jin Peng , Ding Xiang , Peng Longkai , Song Lei , Xiao Zhou , Ao Xiang , Xiao Xiangcheng , Zhou Qiaoling , Xiao Ping , Fan Jue , Zhong Yong 
Published: February 2020

AbstractSince December 2019, a novel coronavirus named 2019 coronavirus (2019-nCoV) has emerged in Wuhan of China and spread to several countries worldwide within just one month. Apart from fever and respiratory complications, acute kidney injury has been observed in some patients with 2019-nCoV. In a short period of time, angiotensin converting enzyme II (ACE2), have been proposed to serve as the receptor for the entry of 2019-nCoV, which is the same for severe acute respiratory syndrome coronavirus (SARS). To investigate the possible cause of kidney damage in 2019-nCoV patients, we used both published kidney and bladder cell atlas data and an independent unpublished kidney single cell RNA-Seq data generated in-house to evaluate ACE2 gene expressions in all cell types in healthy kidneys and bladders.Our results showed the enriched expression of all subtypes of proximal tubule cells of kidney and low but detectable levels of expression in bladder epithelial cells. These results indicated the urinary system is a potential route for 2019-nCoV infection, along with the respiratory system and digestion system. Our findings suggested the kidney abnormalities of SARS and 2019-nCoV patients may be due to proximal tubule cells damage and subsequent systematic inflammatory response induced kidney injury. Beyond that, laboratory tests of viruses and related indicators in urine may be needed in some special patients of 2019-nCoV.
Estimating the Case Fatality Risk of COVID-19 using Cases from Outside China
Authors: Wilson Nick , Kvalsvig Amanda , Barnard Lucy Telfar , Baker Michael G 
Published: February 2020

AbstractThere is large uncertainty around the case fatality risk (CFR) for COVID-19 in China. Therefore, we considered symptomatic cases outside of China (countries/settings with 20+ cases) and the proportion who are in intensive care units (4.0%, 14/349 on 13 February 2020). Given what is known about CFRs for ICU patients with severe respiratory conditions from a meta-analysis, we estimated a CFR of 1.37% (95%CI: 0.57% to 3.22%) for COVID- 19 cases outside of China.
Contacts in context: large-scale setting-specific social mixing matrices from the BBC Pandemic project
Authors: Klepac Petra , Kucharski Adam J , Conlan Andrew JK , Kissler Stephen , Tang Maria L , Fry Hannah , Gog Julia R 
Published: February 2020

AbstractSocial mixing patterns are crucial in driving transmission of infectious diseases and informing public health interventions to contain their spread. Age-specific social mixing is often inferred from surveys of self-recorded contacts which by design often have a very limited number of participants. In addition, such surveys are rare, so public health interventions are often evaluated by considering only one such study. Here we report detailed population contact patterns for United Kingdom based self-reported contact data from over 36,000 volunteers that participated in the massive citizen science project BBC Pandemic. The amount of data collected allows us generate fine-scale age-specific population contact matrices by context (home, work, school, other) and type (conversational or physical) of contact that took place. These matrices are highly relevant for informing prevention and control of new outbreaks, and evaluating strategies that reduce the amount of mixing in the population (such as school closures, social distancing, or working from home). In addition, they finally provide the possibility to use multiple sources of social mixing data to evaluate the uncertainty that stems from social mixing when designing public health interventions.
Microbial redox activity mediated anaerobic pyrite oxidation under circumneutral conditions
Authors: Liu Tong , Hu Yutian , Chen Nan , Ma Linlin , He Qiaochong , Feng Chuanping 
Published: February 2020

AbstractIn modern Earth, anaerobic pyrite oxidation under circumneutral conditions also has great impact on the fate of nitrate in aquifers and sediments, as well as the transportation of toxic metals. However, the mechanism of how microbes mediated this process is still being debated. Electrochemical analysis on pyrite cubic electrode showed that, its oxidation threshold under anaerobic circumneutral conditions (ca. 200 mV) was much lower than that at aerobic acidic conditions (ca. 650 mV), implying possible direct pyrite oxidation by high redox potential cellular components. Sole substrate (pyrite) microbial enrichment cultures with EDTA addition showed higher oxidation rate (0.092 d-1) than that of EDTA-free cultures (0.019 d-1), suggesting that ligands producing pathway was much preferred by microbes than maintaining acidic micro-environments. This hypothesis was supported by amplicon and metagenomic sequencing data, which demonstrated discrepant bacteria involving iron-sulfur oxidation and metabolic potentials in cultures with/without EDTA addition. A concept model was proposed based on experimental data considering different reaction stages and microbial communities. The results shed lights on the potential interactions between microbes and pyrite, which may serve as a model for explaining subsurface pyrite oxidation and optimizing anaerobic pyrite oxidation-based pollutant removal processes.TOC art
Recruitment of Upper-Limb Motoneurons with Epidural Electrical Stimulation of the Primate Cervical Spinal Cord
Authors: Greiner Nathan , Barra Beatrice , Schiavone Giuseppe , James Nicholas , Fallegger Florian , Borgognon Simon , Lacour Stéphanie , Bloch Jocelyne , Courtine Grégoire , Capogrosso Marco 
Published: February 2020

ABSTRACTEpidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting that EES could also improve arm and hand movements after quadriplegia. However, the ability of cervical EES to selectively modulate specific upper-limb motor nuclei remains unclear. Here, we combined a realistic computational model of EES of the cervical spinal cord with experiments in macaque monkeys to explore the mechanisms of this modulation and characterize the recruitment selectivity of cervical stimulation interfaces. Our results indicate that interfaces with lateral electrodes can target individual posterior roots and achieve selective modulation of arm motoneurons via the direct recruitment of pre-synaptic pathways. Intraoperative recordings suggested similar properties in humans. These results provide a framework for the design of neuro-technologies to improve arm and hand control in humans with quadriplegia.
Non-apoptotic role of Cleaved Caspase 3 in Rat Gonocyte
Authors: Nunes Marina , Arantes Anelise Diniz , Tesser Renato Borges , da Silva Priscila Henriques , da Silva Leticia Rocha , de Oliva Samara Urban , Flávia Popi Ana , Stumpp Taiza 
Published: February 2020

AbstractGerm cells emerge from the epiblast and migrate to the gonads, where they become gonocytes. The gonocytes are the precursors of the spermatogonial stem cells, but little is known about their differentiation. The rigid control of gonocyte proliferation, quiescence and pluripotency marker expression is crucial for spermatogonia development. We have previously suggested that cleaved caspase-3 (Casp3) might play a non-apoptotic role in gonocyte quiescence. Here we describe when rat fetal gonocyte enter mitotic arrest and show that Casp3 inhibition in these cells affects the expression of cell cycle genes. The expression of Ki67, p27Kip, Retinoblastoma 1 (pRb1), NANOG and CASP3 was investigated in 15, 17 and 19 days post coitum rat embryo gonads. The results show that Ki67 and pRB1 proteins are downregulated from 15 days post coitum to 19 days post coitum, whereas p27Kip, NANOG and CASP3 are upregulated. This suggests that rat germ cells start to enter quiescence around 15dpc and that CASP3 and NANOG seem to play a role in this process. CASP3 labelling formed a ring in gonocyte cytoplasm, which is clearly distinct from apoptotic cell labelling, and coincided with NANOG labelling. CASP3 inhibition lead to an increase ofPcnaexpression and to a decrease ofp27kipandp21cipexpression. These results suggest that cleaved CASP3 has a role in rat male germ cell development which can be related to the control of the cell cycle genes.
Spinning gasodynamic projectile system identification experiment design
Authors: Lichota Piotr , Jacewicz Mariusz , Szulczyk Joanna 
Published: February 2020

Purpose
The purpose of this paper is to present the methodology that was used to design a system identification experiment of a generic spinning gasodynamic projectile. For this object, because the high-speed spinning motion, it was not possible to excite the aircraft motion along body axes independently. Moreover, it was not possible to apply simultaneous multi-axes excitations because of the short time in which system identification experiments can be performed (multi-step inputs) or because it is not possible to excite the aircraft with a complex input (multi-sine signals) because of the impulse gasodynamic engines (lateral thrusters) usage.

Design/methodology/approach
A linear projectile model was used to obtain information about identifiability regions of stability and control derivatives. On this basis various sets of lateral thrusters’ launching sequences, imitating continuous multi-step inputs were used to excite the nonlinear projectile model. Subsequently, the nonlinear model for each excitation set was identified from frequency responses, and the results were assessed. For comparison, the same approach was used for the same projectile exited with aerodynamic controls.

Findings
It was found possible to design launching sequences of lateral thrusters that imitate continuous multi-step input and allow to obtain accurate system identification results in specified frequency range.

Practical implications
The designed experiment can be used during polygonal shooting to obtain a true projectile aerodynamic model.

Originality/value
The paper proposes a novel approach to gasodynamic projectiles system identification and can be easily applied for similar cases.
Ulterior motives in peer and expert supplementary online reviews and consumers' perceived deception
Authors: Siddiqi Umar Iqbal , Sun Jin , Akhtar Naeem 
Published: February 2020

PurposeThe study aims to examine the effects of ulterior motives in peer and expert supplementary online hotel reviews on consumers' perceived deception, dissatisfaction, and its downstream effects on altruistic response and repurchase intentions. The research also examines the moderating role of hotel attribute performance on perceived deception and its consequents.Design/methodology/approachThis study used convenient non-probability sampling and collected data from 448 inbound tourists in China. It used partial least square structural equation modeling technique and SmartPLS 3.0 for analyzing the main and moderating effects of the variables.FindingsThe ulterior motives in peer and expert supplementary reviews significantly affect perceived deception, further leading to consumers' dissatisfaction and engagement in altruistic response. Noticeably, consumers' dissatisfaction is positively associated with repeat purchase intentions. Hotel attribute performance significantly moderates the relationship between the ulterior motives in supplementary reviews and consumers' perceived deception.Originality/valueThe study examines the key issue in online hotel reviews using the expectancy disconfirmation theory and identifies consumers' altruistic behavior because of their dissatisfaction, contributing to ethics and consumer behavior literature. Moreover, the research offers prolific implications for hotel and travel websites and hoteliers in the study context.
Viscoelastic-viscoplastic combined constitutive model for glassy amorphous polymers under loading/unloading/no-load states
Authors: Matsubara Seishiro , Terada Kenjiro , Maeda Ryusei , Kobayashi Takaya , Murata Masanobu , Sumiyama Takuya , Furuichi Kenji , Nonomura Chisato 
Published: February 2020

PurposeThis study aims to propose a novel viscoelastic–viscoplastic combined constitutive model for glassy amorphous polymers within the framework of thermodynamics at finite strain that is capable of capturing their rate-dependent inelastic mechanical behavior in wide ranges of deformation rate and amount.Design/methodology/approachThe rheology model whose viscoelastic and viscoplastic elements are connected in series is set in accordance with the multi-mechanism theory. Then, the constitutive functions are formulated on the basis of the multiplicative decomposition of the deformation gradient implicated by the rheology model within the framework of thermodynamics. Dynamic mechanical analysis (DMA) and loading/unloading/no-load tests for polycarbonate (PC) are conducted to identify the material parameters and demonstrate the capability of the proposed model.FindingsThe performance was validated in comparison with the series of the test results with different rates and amounts of deformation before unloading together. It has been confirmed that the proposed model can accommodate various material behaviors empirically observed, such as rate-dependent elasticity, elastic hysteresis, strain softening, orientation hardening and strain recovery.Originality/valueThis paper presents a novel rheological constitutive model in which the viscoelastic element connected in series with the viscoplastic one exclusively represents the elastic behavior, and each material response is formulated according to the multiplicatively decomposed deformation gradients. In particular, the yield strength followed by the isotropic hardening reflects the relaxation characteristics in the viscoelastic constitutive functions so that the glass transition temperature could be variant within the wide range of deformation rate. Consequently, the model enables us to properly represent the loading process up to large deformation regime followed by unloading and no-load processes.
A conceptual framework for improving effectiveness of risk management in supply networks
Authors: Chaudhuri Atanu , Ghadge Abhijeet , Gaudenzi Barbara , Dani Samir 
Published: February 2020

PurposeThe purpose of the paper is to develop a conceptual framework for improving the effectiveness of risk management in supply networks following a critical literature review.Design/methodology/approachA critical review of 91 scholarly journal articles published between 2000 and 2018 supports the development of an integrated conceptual framework.FindingsThe findings emphasize that supply chain integration (SCI) can have both a positive and negative impact on the effectiveness of risk management in supply networks. It is possible to have a positive effect when SCI can be used to develop competencies in joint risk planning within the organization and with wider supply network members and, in turn, to develop collaborative risk management capabilities. Supply network characteristics can influence whether and the extent to which SCI has a positive or negative impact on risk management effectiveness.Research implicationsThe conceptual framework can be used to empirically assess the role of SCI for effective risk management. Dynamic evaluation of the effectiveness of risk management and potential redesign of the supply network by considering other contingent factors are some future research avenues.Practical implicationsThere is a need for developing specific competencies in risk planning within organizations and joint risk planning with supply network members which, in turn, can help develop collaborative risk management capabilities to improve the effectiveness of risk management in supply networks. Network characteristics will influence whether and the extent to which SCI results in the effectiveness of risk management.Originality valueMoving beyond recent (systematic) reviews on supply chain risk management, this study develops a novel conceptual framework interlinking SCI and the effectiveness of risk management while considering network characteristics.