bluuebunny/crossref_metadata_2025_split huggingface dataset:
HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
Authors: Wang Yaya , Argiles-Castillo Diana , Kane Emma I. , Zhou Anning , Spratt Donald E. 
Published: April 2020

ABSTRACT
Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and apoptosis. To date, 28 HECT E3 ubiquitin ligases have been identified in humans, and recent studies have begun to reveal how these enzymes control various cellular pathways by catalyzing the post-translational attachment of ubiquitin to their respective substrates. New studies have identified substrates and/or interactors with different members of the HECT E3 ubiquitin ligase family, particularly for E6AP and members of the neuronal precursor cell-expressed developmentally downregulated 4 (NEDD4) family. However, there still remains many unanswered questions about the specific roles that each of the HECT E3 ubiquitin ligases have in maintaining cellular homeostasis. The present Review discusses our current understanding on the biological roles of the HECT E3 ubiquitin ligases in the cell and how they contribute to disease development. Expanded investigations on the molecular basis for how and why the HECT E3 ubiquitin ligases recognize and regulate their intracellular substrates will help to clarify the biochemical mechanisms employed by these important enzymes in ubiquitin biology.
Structural and Energy Characteristics of NiAl Alloys with Deviations from Stoichiometric Composition. General Provisions. Part 1
Authors: Potekaev A.I. , Chaplygina A.A. , Starostenkov M.D. , Klopotov A.A. , Kulagina V.V. , Chaplygin P.A. , Marchenko E.S. 
Published: April 2020

The research results are presented in two parts. The first part presents data describing the general state of the problem of low-stability pre-transitional structural phase states in intermetallides of the Ni-Al system. Physical interpretations of low-stability structural phase states in condensed systems are described along with the applied physical-mathematical model based on a calculated block of 32x32x32 elementary cells (65536 atoms) of an ordered BCC structure (superstructure B2, Pearson symbol cP2). The study is carried out by Monte Carlo methods using the Metropolis algorithm for an intermetallic NiAl sample of stoichiometric composition (used as an example). It is found out that a kind of hysteresis is observed during thermal cycling. The presence of such hysteresis indicates the irreversibility of the occurring processes. This implies a difference in the structural phase states at the heating and cooling stages.
The second part of the paper will demonstrate the results of a computer simulation of changes in structural phase states. The focus will be made on the low-stability pre-transitional structural phase states and energy characteristics of intermetallides образом with deviations from the stoichiometric composition of Ni45Al55 and Ni55Al45.
Ciudadanía, sufragio y propiedad en las Constituciones francesas de 1791 y 1793
Authors: Sánchez Quiñones Luis 
Published: April 2020

En apenas tres años, la Revolución Francesa promulgó dos Constituciones en las que los derechos políticos contaron con una perspectiva radicalmente opuesta. El primero de los textos, suscrito en 1791, planteaba un derecho de sufragio radicado en la propiedad de raíces lockianas. Sin embargo, en 1793 se estableció un derecho de sufragio mucho más amplio basado en la mera condición del sujeto y obviando las referencias a la propiedad.Recibido: 11 octubre 2019Aceptado: 20 febrero 2020Publicación en línea: Artículos en Prensa 07 abril 2020; Núm. 5 (2020) 26 junio 2020
Structure and characteristics of boron-containing steels for fasteners
Authors: Haretski H. P. , Solovey N. F , Shenets S. L. , Tereshchenko A. V. , Avdeev S. V. , Pokrovskii A. I. , Tolkacheva O. I. 
Published: April 2020

According to TU 14-1-4486-88 and TU 14-1-5490-2004, in accordance with international standards DIN EN 10263-4, OJSC «BSW – Management Company of the Holding «BMC» produces hot-rolled products of the following grades of steel: 20Г2Р, 30Г1Р, 20MnB4, 30MnB4 and 32CrB4 microalloyed with boron. They are used for the manufacture of fasteners instead of previously used steels 35X, 38X and 40X. The use of boron-containing steels reduces the surface defects of hardware; to increase the stability of the mechanical properties of bolts, screws, studs, strength class 8.8 and 10.9 by GOST 1759.4-87; to achieve a high level of toughness at negative temperatures. It is shown that steel 20Г2Р provides stable mechanical properties of products up to M27 (in contrast to steel grades 35X, which are designed exclusively for bolts of class M16 8.8). The boron-containing steels in the delivery state with the structure of granular perlite have high technological plasticity – in the cold, the bolt head is formed and the thread is rolled without tearing in the thread hollows, as is the case with chromium steels of type 40X. It was found that their ductility increases due to the low content of carbon and chromium, as well as the formation of dispersed carbonitride-boride phases of a globular form.
Current Evidence of Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review, Meta-analysis, and Meta-regression of Prospective Clinical Studies
Authors: Cho Woo Sup , Chung Sun Gun , Kim Won , Jo Chris H. , Lee Shi-Uk , LEE SANG-YOON 
Published: April 2020

Abstract
Purpose Although several studies with animals have reported the effects of mesenchymal stem cells (MSCs) for tendon regeneration, little is known about the efficacy and safety of MSCs in human tendon disorders. We performed this meta-analysis to evaluate the efficacy and safety of MSC therapy in patients with tendon disorders enrolled in prospective clinical studies. Methods We systematically searched prospective clinical studies investigating the effects of MSCs administration on human tendon disorders with at least a 6-month follow-up period on PubMed-Medline, Embase, and Cochrane Library databases. The primary outcome of interest was the change in pain on motion related to tendon disorders. We performed a pairwise meta-analysis using the fixed-effects model to assess treatment response, which was calculated by the standardized mean difference. Meta-regression analyses were performed to assess the relationship between MSCs dose and pooled effect sizes in each cell dose. Results Four prospective clinical trials investigating the effect of MSCs on tendon disorders were retrieved. MSCs showed significant pooled effect size (overall Hedge’s g pooled standardized mean difference (SMD) = 1.868; 95% confidence interval [CI], 1.274–2.462; P < 0.001). The treatment with MSCs improved all the aspects analyzed, i.e. pain, functional scores, radiologic parameters (magnetic resonance image or ultrasonography), and arthroscopic findings. In the meta-regression analysis, there was a significant cell dose-dependent response in pain relief (Q = 9.06, P = 0.029). While three studies reported mild adverse events after MSCs injection, these were not severe and relieved spontaneously. Conclusions Our meta-analysis revealed that MSC therapy may improve pain, function, radiologic, and arthroscopic parameters in patients with tendon disorders. Due to the small number of studies in this meta-analysis and considering the increasing MSCs applications, there is a strong need for large-scale randomized controlled trials to confirm the long-term functional improvement as well as the adverse effects of MSC therapies in tendon disorders.
Research on the supervision mechanism of new energy time-sharing rental Vehicles: An evolutionary game analysis
Authors: Zhang Wei , Chen Yejian , Wan Xiaoyu 
Published: April 2020

Abstract
Background：It is difficult to break the “production and marketing dilemma” by relying only on the production enterprises and consumers. This paper introduces the government into market subject and constructs a three-party dynamic evolution game model between government, enterprises, and consumers to reveal the control strategy. This paper makes a concrete analysis and verifies the model with a case study by revealing the game process between the regulation strategy and behavior decision of enterprises and consumers.Results：When the key parameters are in different numerical ranges, the system has four evolutionary stability results. By appropriately increasing the amount of subsidies and penalties, increasing the proportion of compensation coefficient to consumers, and urging enterprises to reduce operating costs, the government is conducive to the healthy development of the new energy timesharing automobile industry.Conclusions：The subsidy range and punishment intensity have a positive effect on the evolution of the system to the ideal state, the consumer compensation coefficient has a positive effect on the evolution of the system to the ideal state, the effort of operating costs has a negative effect on the evolution of the system to the ideal state. The study can provide a theoretical basis and a reference for policy formulation and decision-making.
Research on the Spatial Effect of Green Economic Efficiency in China from the Perspective of Informatization
Authors: Tian Xinbao , Yu Chuanhao 
Published: April 2020

Abstract
Background: Green economy has been paid more and more attention in the information age. Informatization plays an important role in the development of green economy by the transmission of industrial structure rationalization and upgrading. Because of the spatial mobility of information, it is necessary to study the spatial spillover effect of information on the efficiency of green economy. In this paper, the non-radial directional distance function and the comprehensive index method are used to evaluate the efficiency of green economy and informatization respectively. On this basis, the spatial characteristics of the two are analyzed. Finally, the spatial econometric model is used to analyze the spatial impact of informatization on the efficiency of green economy. Results: The following findings can be drawn: (i)The spatial distribution of the green economy efficiency and informatization are unbalanced; (ii) There is a significant spatial spillover effect in the efficiency of green economy; (iii) The development of informatization plays an important impact on the efficiency of green economy. Conclusions: It can be seen that informatization plays an important role in the development of green economy, so we can get the following suggestions: (i) Developing green economy according to different conditions of different places. (ii) Establishing regional coordination mechanism of green economic development. (iii) Using informatization to promote the development of green economy.
The global impact of Aspergillus infection on COPD
Authors: Denning David , Hammond Emily E. , McDonald Charles S. , Vestbo Jørgen 
Published: April 2020

Abstract
Background Advanced chronic obstructive pulmonary disease (COPD) often leads to hospitalisation and invasive aspergillosis (IA) is a serious complication. Aspergillus sensitisation may worsen symptoms in COPD. In 2016, the global estimate of COPD was 251 million affected. Methods We identified published papers between January 2000 and May 2019 with >50 subjects and GOLD criteria for grade II, III or IV (FEV1/FVC <70% and FEV1 <80%) using spirometry. Given limited data, a conservative 10.5% estimate of annual hospitalisation was assumed based on studies in Algeria. A separate literature search assessed the impact of Aspergillus sensitisation on severity of COPD (by FEV1). Hospitalised COPD patients develop IA in 1.3% -3.9%, based on positive cultures of Aspergillus spp. and radiological findings. Mortality was estimated based on the diagnosis of IA being made and patients treated. Results We re-estimated the global prevalence of COPD GOLD stages II-IV at 552,300,599 people (7.39% of the population) with 339,206,893 (8.58%) in Asia, 85,278,783 (8.52%) in the Americas, 64,298,051 (5.37%) in Africa, 59,484,329 (7.77%) in Europe and 4,032,543 (10.86%) in Oceania. Aspergillus sensitisation prevalence in COPD was 13.6% (7.0-18.3%) and not related to lower predicted FEV1% (P >0.05). An estimated 57,991,563 (10.5%) people with COPD are admitted to hospital annually and of these 753,073 (1.3%) - 2,272,322 (3.9%) develop IA and 540,451 – 977,082 deaths (43-72%) are predicted annually, assuming the diagnosis is made and treatment given. Conclusions: The prevalence of COPD is much higher than previously estimated. Mortality may be higher that estimated as not all diagnosis of IA is probably made. Improved rapid diagnosis of IA using culture and non-culture based techniques is required in COPD hospital admissions to reduce mortality.
Assessment of Anti-oxidant and Anti-inflammatory Properties of Green Tea in Critically Ill Patients with Pneumonia
Authors: Labbani-Motlagh Zohre , Abrishami Ramin , Motamed Saeed Mohammadi , Shahrami Reza 
Published: April 2020

Abstract
Background: Systemic inflammatory response syndrome is common in critically ill patients and negatively affects clinical outcomes. Preventing oxidative damage, may suppress this systemic response. Previous studies confirmed that polyphenols in green tea have both antioxidant and immuno-stimulant effect, so there could be a probability of green tea clinical application. Two groups of 8 patients enrolled in this randomized, controlled clinical trial. Treatment group received Green Tea Extract (GTE), and placebo group received extract's solvent for 7 days. Blood samples taken 3 times/week and oxidative, physiologic and inflammatory markers were measured. Results: Differences between the baselines for each variable were not significant. FRAP value showed slower decrease in GTE group. Thiol level increased in GTE group and decreased in Placebo group. IL-6 and APACHE II score were lower in GTE group on day7. Leucocyte count showed overall increase in GTE group and decrease in placebo group. Differences between two groups in all aforementioned variables were statistically insignificant.Conclusion: As a conclusion green tea had no significant effect on all measured variables; but in GTE group despite better oxidative status in the first 3 days, more inflammation was observed on day7. Considering small sample size further investigations are needed.
Quantitative Analysis of Contrast-Enhanced Ultrasound in Evaluation of Preoperative Chemotherapy for Wilms Tumor in Children：Pilot Study
Authors: Xu Shuai , Song Hongcheng , Zhang Weiping , Wang Xiaoman , Wang Ning , Lin Defu , Liu Pei , Wang Guannan , Yang Yang , Chen Shuofan , Sun Ning 
Published: April 2020

Abstract
Background : Contrast enhanced ultrasound (CEUS) has been actively used in the detection of lesions in many organs especially in kidney and liver, but there is no report in evaluation of preoperative chemotherapy for Wilms tumor in children.Methods: 8 children with Wilms tumor were enrolled in this study. All patients accepted preoperative chemotherapy for 4-8 weeks. Each child accepted CEUS examination for 3 times. The image files and the data were analyzed through software. Results: The group included 8 cases with tumor volume from 155.71 to 1624.16 cm3. 6 patients accepted preoperative chemotherapy for 8 weeks before surgery, 2 cases underwent preoperative chemotherapy for 4 weeks. Each child accepted CEUS examination for 3 times and no one showed discomfort to the SonoVue contrast agent. By the comparison from the 3 times CEUS, tumor volume in most of the children was significantly reduced, and the blood perfusion intensity in the tumor was prominently weakened. The results of linear regression showed that the changes of PI between the first and second CEUS examinations and between the second and third CEUS examinations had correlation with the reduction volume of Wilms tumor.Conclusions: It is the first time to apply quantitative analysis of CEUS in evaluation of preoperative chemotherapy for Wilms tumor in children. CEUS is a safe examination in children. CEUS videos could show clearly the changes of tumor perfusion during preoperative chemotherapy. PI can precisely reflect the degree of sensitivity of tumor to chemotherapy in early stage of preoperative chemotherapy.
A COVID-19 patient with multiple negative results for PCR assays outside Wuhan, China: a case report
Authors: Chen Li-Da , Li Hao , Ye Yu-Ming , Wu Zhi , Huang Ya-Ping , Zhang Wei-Liang , Lin Li 
Published: April 2020

Abstract
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency of major international concern. Real-time RT-PCR assays are recommended for diagnosis of COVID-19. Here we report a rare case of COVID-19 with multiple negative results for PCR assays outside Wuhan, China. Case presentation: A 32-year old male was admitted to our hospital because of 6 days of unexplained fever on January 29, 2020. He had come from Wuhan city 10 days before admission. 5 days before admission, no abnormality was noted in laboratory test, chest radiography, and nasopharyngeal swab test for the SARS-CoV-2 nucleic acid. The patient was treated with ibuprofen for alleviating fever. On admission, chest computed tomography showed multiple ground-glass opacities in right lower lung field. COVID-19 was suspected. 3 times of nasopharyngeal swab specimens were collected after admission. However, none of the specimens were positive. The patient was confirmed with COVID-19 after fifth SARS-CoV-2 nucleic acid test. He was treated with lopinavir/ritonavir, recombinant human interferon alfa-2b inhalation, methylprednisolone. After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. Conclusion: This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. Repeat swab tests are helpful in diagnosis for this kind of patients.
A population-based retrospective study of the spread of COVID-19 from Wuhan to Henan province, China
Authors: Li Fei , Du Xufei , Geng Xinwei , Zhang Min , Zhao Yun , Li Wen , Chen Zhihua , Ying Songmin , Shen Huahao 
Published: April 2020

Abstract
The epidemic of COVID-19 has now spread globally and affected over 110 countries. As of Mar 10th, using publicly available data and official news reports in Henan province, we tracked a total of 1272 cases and a retrospective study was conducted to investigate the related factors in COVID-19 spread and control. We confirmed 554 primary patients had travel or residential history of Wuhan in the recent 2 weeks. Secondary cases accounted for 77.9% (141/181) among all the patients aged 61 or older, in whom contacted with unconfirmed returnees from Wuhan was responsible for 27.0% (38/141). The median incubate period is 7 (IQR, 4-10) days by analyzing time information in 469 cases. For 442 patients with discharge dates, the duration from onset to cure is 19 (IQR, 15-23) days. The time from onset to seeking care at a hospital varied in age groups, and differed between primary and secondary cases. Patients visiting different hospitals affected the time from seeking care to cure. Thus, our results showed the spread of COVID-19 and factors associated with outcomes of patients in Henan province, which helps to understand the epidemiological features outside of the epidemic area and control the disease in other regions and countries.
Impact of cytoreductive surgery on outcomes of metastatic appendiceal carcinoma: a real-world, population-based study
Authors: Abdel-Rahman Omar 
Published: April 2020

Aim:
To evaluate the impact of cytoreductive surgery on the outcomes of patients with metastatic appendiceal carcinoma.
Methods:
Surveillance, Epidemiology and End Results (SEER) database was accessed and patients with metastatic appendiceal carcinoma diagnosed (2010–2015) were reviewed. Kaplan–Meier survival estimates/log-rank testing were then used to assess overall survival outcomes according to cytoreductive surgery. Multivariable Cox regression analysis was then used to evaluate factors affecting cancer-specific survival. Factors included in this model were age, race, sex, stage and histology and cytoreductive surgery.
Results:
A total of 1339 patients with metastatic appendiceal carcinoma were included in the current study. Using Kaplan–Meier survival estimates to evaluate overall survival, patients with surgery for metastatic disease have better overall survival compared with patients without surgery for metastatic disease (p < 0.001). Stratifying survival analysis according to histology, the overall survival benefit from surgery for the metastases seems to be limited to patients with mucinous adenocarcinoma (p = 0.002) rather than patients with nonmucinous adenocarcinoma (p = 0.401). Multivariable Cox regression analysis was then conducted to evaluate factors predicting cancer-specific survival. The following factors were associated with worse cancer-specific survival: African-American race (hazard ratio [HR]: 1.356; 95% CI: 1.036–1.774; p = 0.026), more advanced stage (HR: 3.910; 95% CI: 2.735–5.588; p < 0.001), nonmucinous adenocarcinoma (HR for signet ring carcinoma vs mucinous adenocarcinoma: 2.119; 95% CI: 1.674–2.683; p < 0.001) and no surgical resection of metastatic disease (HR: 1.273; 95% CI: 1.067–1.519; p < 0.001).
Conclusion:
The current study suggests that among patients with metastatic appendiceal carcinoma, surgical cytoreduction of metastatic disease is associated with improved outcomes for patients with mucinous adenocarcinoma but not in patients with nonmucinous adenocarcinoma.
The effects of extensive listening on Vietnamese students’ listening skills
Authors: Le Thinh Van , Pham Sa Kim 
Published: April 2020

University students in Vietnam do not have enough time to practise their listening inside the classroom. Outside the classroom, they do not have chance to practice it. To supplement time constraint in the classroom, extensive listening was employed to assist students to develop their listening skills. The study aims to investigate whether extensive listening ameliorates students’ listening proficiency. Two groups of students from two intact classes: the control group (n = 32) and the experimental group (n = 32) were selected. Before the semester started, all students sat for the pre-listening test. After that, students in the experimental group were advised to listen to fifteen suggested sound files with one file for each week. They were also instructed some listening strategies to self-practise at home while students in the control group did not do any listening tasks at home. After 15 weeks, students in both groups took the post-listening test. The post-interview was conducted to explore how students practiced their listening out of school. The results showed that the experimental group outperformed the control group in the post-test. Some students in the experimental group reported that they practised listening many times and tried to learn as much vocabulary as possible.