bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of root pruning on the arbuscular mycorrhizal symbiosis in grapevine rootstocks
Authors: Holland Taylor , Bowen Pat , Kokkoris Vasilis , Richards Andrew , Rosa Daniel , Hart Miranda 
Published: November 2019

Abstract

Background
Arbuscular mycorrhizal fungi provide benefits to plants, especially under stressful growing conditions. These symbiotic fungi can be applied as biofertilizers prior to transplant in order to increase establishment success in the field. Roots are often trimmed at the time of transplant to reduce the probability of J-rooting, the upward orientation of roots within a planting hole which can lead to root death and disease. The effect of root trimming on the mycorrhizal symbiosis is unknown. It is possible that trimming may remove the active mycelium, nullifying the effect of inoculation. We conducted a greenhouse study to test the effect of root trimming on the mycorrhizal symbiosis in grapevine.

Results
The mycorrhizal symbiosis persisted after root trimming. Trimming reduced the abundance of AM fungi in older roots. The fungi were able to recolonize the new roots in trimmed vines, and these roots had more arbuscules compared to older roots, which had mostly vesicles. Trimmed vines had lower shoot, but not root, biomass.

Conclusions
The mycorrhizal symbiosis persisted in the roots, despite trimming, likely due to fungal structures in older, untrimmed roots serving as propagules. We conclude that inoculation with AM fungi prior to field transplant is robust to root trimming, at least for the isolate examined in this study.
Identification of essential attributes in conclusions of student reports
Authors: López-López Aurelio , González-López Samuel , García-Gorrostieta Jesús Miguel 
Published: November 2019

Abstract
This work seeks to help students in improving their first research reports, based on natural language processing techniques. We present a Conclusion model that includes three schemes: Goal Connectedness, Judgment and Speculation. These subsystems try to account for the main expected attributes in conclusions, specifically the Connectedness with the general objective of the research, the evidence of value Judgments, and the presence of Future work as a result of the student reflection after the inquiry. The article details the schemes, a validation of the approach in an annotated corpus, and a pilot test with undergraduate students. Results of a prior validation indicate that student writings indeed adhere to such attributes, especially at graduate level. Statistical results of the pilot test showed that undergraduate students in an experimental group achieved improved conclusion content when compared with the control group.
Patterns and drivers of species richness and turnover of neo-endemic and palaeo-endemic vascular plants in a Mediterranean hotspot: the case of Crete, Greece
Authors: Lazarina Maria , Kallimanis Athanasios S. , Dimopoulos Panayotis , Psaralexi Maria , Michailidou Danai-Eleni , Sgardelis Stefanos P. 
Published: November 2019

Abstract

Background
Exploring species richness and turnover patterns and their drivers can provide new insights into underlying mechanisms shaping community assembly, with significant implications for biodiversity conservation. Here, we explored diversity patterns of non-endemic, neo-endemic and palaeo-endemic vascular plants in Crete, Greece, a Mediterranean hotspot of plant richness and endemism. We evaluated the relationship between α-diversity and environmental (bioclimatic variables, topography), and anthropogenic variables by Generalized Additive Models, after accounting for spatial autocorrelation. Then, we quantified turnover using the novel concept of zeta diversity (the number of shared species by multiple sites), a framework which allows to explore the full spectrum of compositional turnover, the contribution of rare and widespread species to observed patterns and the underlying processes shaping them. Finally, we explored the abiotic and biotic effects, i.e. how well one category of species (non-endemics, palaeo-endemics, neo-endemics) predicts the patterns of the other categories, on zeta diversity by multi-site Generalized Dissimilarity Modelling.

Results
We found a strong correlation between neo-endemic and palaeo-endemic α-diversity, with climate, topography, and human impact driving species richness. Zeta diversity analysis revealed a sharper decrease of shared palaeo-endemic species, followed by neo-endemics, and then by non-endemics with the number of sites considered to estimate compositional turnover. Perhaps, the narrow distributions of palaeo-endemics as relict species and often habitat specialists, thus persisting locally, and of neo-endemics that may have not reached yet their potential geographical range, resulted in the observed zeta diversity decline pattern. Deterministic processes controlled species turnover of rare non-endemic and neo-endemic species, while deterministic and stochastic processes contributed similarly to palaeo-endemic turnover. However, stochasticity dominates in the case of widespread species in all occasions. The environmental and anthropogenic variables were poor predictors of compositional turnover, especially of widespread species. However, the non-endemic species composition was correlated to rare palaeo-endemics and neo-endemics, highlighting the importance of biotic effects in driving turnover patterns.

Conclusions
It seems that centers of neo-endemism of vascular plants coincide with centers of palaeo-endemism in Crete, but species richness and species turnover are shaped by different drivers.
Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Authors: Sehn Laurie H. , Herrera Alex F. , Flowers Christopher R. , Kamdar Manali K. , McMillan Andrew , Hertzberg Mark , Assouline Sarit , Kim Tae Min , Kim Won Seog , Ozcan Muhit , Hirata Jamie , Penuel Elicia , Paulson Joseph N. , Cheng Ji , Ku Grace , Matasar Matthew J. 
Published: November 2019

PURPOSE Patients with transplantation-ineligible relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) fare poorly, with limited treatment options. The antibody-drug conjugate polatuzumab vedotin targets CD79b, a B-cell receptor component. METHODS Safety and efficacy of polatuzumab vedotin with bendamustine and obinutuzumab (pola-BG) was evaluated in a single-arm cohort. Polatuzumab vedotin combined with bendamustine and rituximab (pola-BR) was compared with bendamustine and rituximab (BR) in a randomly assigned cohort of patients with transplantation-ineligible R/R DLBCL (primary end point: independent review committee [IRC] assessed complete response [CR] rate at the end of treatment). Duration of response, progression-free survival (PFS), and overall survival (OS) were analyzed using Kaplan–Meier and Cox regression methods. RESULTS Pola-BG and pola-BR had a tolerable safety profile. The phase Ib/II pola-BG cohort (n = 27) had a CR rate of 29.6% and a median OS of 10.8 months (median follow-up, 27.0 months). In the randomly assigned cohort (n = 80; 40 per arm), pola-BR patients had a significantly higher IRC-assessed CR rate (40.0% v 17.5%; P = .026) and longer IRC-assessed PFS (median, 9.5 v 3.7 months; hazard ratio [HR], 0.36, 95% CI, 0.21 to 0.63; P < .001) and OS (median, 12.4 v 4.7 months; HR, 0.42; 95% CI, 0.24 to 0.75; P = .002; median follow-up, 22.3 months). Pola-BR patients had higher rates of grade 3-4 neutropenia (46.2% v 33.3%), anemia (28.2% v 17.9%), and thrombocytopenia (41% v 23.1%), but similar grade 3-4 infections (23.1% v 20.5%), versus the BR group. Peripheral neuropathy associated with polatuzumab vedotin (43.6% of patients) was grade 1-2 and resolved in most patients. CONCLUSION Polatuzumab vedotin combined with BR resulted in a significantly higher CR rate and reduced the risk of death by 58% compared with BR in patients with transplantation-ineligible R/R DLBCL.
Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-Up From a Community-Based Cohort
Authors: Cho Nam H , Ku Eu Jeong , Jung Kyoung Yeon , Oh Tae Jung , Kwak Soo Heon , Moon Jae Hoon , Park Kyong Soo , Jang Hak C , Kim Yoon Ji , Choi Sung Hee 
Published: November 2019

Abstract

Context
The long-term association between multiple cytokines and progression to diabetes is still uncertain.

Objective
To identify which cytokines could predict progression to prediabetes and type 2 diabetes over 10 years.

Methods
The study included 912 participants aged 40 to 69 years at baseline from the Ansung cohort, part of the Korea Genome Epidemiology Study. At baseline, a 75-g oral glucose tolerance test and 8 cytokines were measured: plasminogen activator inhibitor 1 (PAI-1), resistin, interleukin 6, leptin, monocyte chemoattractant protein 1, tumor necrosis factor alpha, retinol binding protein 4 (RBP4), and adiponectin. People with normal glucose tolerance (NGT, n = 241) and prediabetes (n = 330) were followed-up biennially for 10 years. Multinomial logistic regression analysis was used to evaluate the predictability of cytokines on the new-onset prediabetes and type 2 diabetes.

Results
At 10 years, 38 (15.8%) and 82 (34.0%) of those with NGT had converted to prediabetes and type 2 diabetes, respectively. Of those with prediabetes, 228 (69.1%) had converted to type 2 diabetes. In people with NGT or prediabetes at baseline, the highest tertile of RBP4 was associated with a 5.48-fold and 2.43-fold higher risk of progression to type 2 diabetes, respectively. The odds for converting from NGT to prediabetes in the highest tertile of PAI-1 and the lowest tertile of adiponectin were 3.23 and 3.37, respectively. In people with prediabetes at baseline, those in the highest tertile of resistin were 2.94 time more likely to develop type 2 diabetes (all P &lt; 0.05).

Conclusions
In this 10-year prospective study, NGT with higher serum RBP4 and PAI-1, and with lower adiponectin were associated with new-onset prediabetes and type 2 diabetes.
The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study
Authors: Vandenberg Laura N , Prins Gail S , Patisaul Heather B , Zoeller R Thomas 
Published: November 2019

Abstract
For many endocrine-disrupting chemicals (EDCs) including Bisphenol A (BPA), animal studies show that environmentally relevant exposures cause harm; human studies are consistent with these findings. Yet, regulatory agencies charged with protecting public health continue to conclude that human exposures to these EDCs pose no risk. One reason for the disconnect between the scientific consensus on EDCs in the endocrinology community and the failure to act in the regulatory community is the dependence of the latter on so-called “guideline studies” to evaluate hazards, and the inability to incorporate independent scientific studies in risk assessment. The Consortium Linking Academic and Regulatory Insights on Toxicity (CLARITY) study was intended to bridge this gap, combining a “guideline” study with independent hypothesis-driven studies designed to be more appropriate to evaluate EDCs. Here we examined an aspect of “guideline” studies, the use of so-called “historical controls,” which are essentially control data borrowed from prior studies to aid in the interpretation of current findings. The US Food and Drug Administration authors used historical controls to question the plausibility of statistically significant BPA-related effects in the CLARITY study. We examined the use of historical controls on 5 outcomes in the CLARITY “guideline” study: mammary neoplasms, pituitary neoplasms, kidney nephropathy, prostate inflammation and adenomas, and body weight. Using US Food and Drug Administration–proposed historical control data, our evaluation revealed that endpoints used in “guideline” studies are not as reproducible as previously held. Combined with other data comparing the effects of ethinyl estradiol in 2 “guideline” studies including CLARITY-BPA, we conclude that near-exclusive reliance on “guideline” studies can result in scientifically invalid conclusions.
Cervical cancer screening programme
Authors: Peate Ian 
Published: November 2019

Screening for cervical cancer saves lives. This article provides an overview of cervical screening programmes offered by the NHS. All four countries in the UK provide a cervical cancer screening programme. Cervical screening identifies apparently healthy women who may be at increased risk of a disease or condition; this then provides an opportunity for earlier treatment or better informed decisions. In some instances, the healthcare assistant and assistant practitioner (HCA and AP) may be needed in order to provide assistance with the screening procedure, offering the woman physical and psychological support. This article offers the reader an overview of the cervix, along with a brief description of signs and symptoms of cervical cancer.
PROSPECTS FOR THE USE OF ASPERGILLUS NIGER CHITIN-GLUCAN COMPLEX IN THE COMPOSITION OF ELECTRICAL INSULATING TYPES OF PAPER
Authors: Smirnova Ekaterina Grigor'yevna , Zhuravleva Nataliya Mikhaylovna , Kiesevetter Dmitriy Vladimirovich , Reznik Aleksandr Sergeyevich 
Published: November 2019

The paper presents the results of experiments to improve the performance of insulating paper as a component of high-voltage paper-impregnated insulation by introducing the modifying additive into the paper mass. Environmentally safe and economically feasible method of obtaining modifying additives of the chitin-glucan complex of Aspergillus niger (A.n.) which is a large-tonnage waste production of citric acid is proposed. The modifying additive was introduced into the paper mass in an amount of 5–10% to the mass of absolutely dry fiber of sulfate insulating cellulose. The paper samples were subjected to accelerated thermal aging at 140 °C for 250 hours. The values of the short – term electrical strength of the samples with the modifying additive, both in the initial and in the aged state, exceeded the similar characteristic of the paper sample without additives. for the paper made of 100% cellulose after 250 hours of accelerated thermal aging the maximal mechanical tensile strength decreased by 2.1 times; for paper containing 5% HGC A.n. – by 1.5 times and for the insulating paper, which was introduced into 10% of the modifying additive, the specified parameter during the test has not changed. Comparative evaluation of the sorption activity of the cellulose component was carried out by determining the light transmission coefficient of transformer oil relative to the standard at the process of thermal aging. It was found that the modification of insulating paper by biopolymer also increases its sorption activity in relation to the products of destruction of paper-impregnated insulation components under the catalytic effect of copper.
THE COMPONENT COMPOSITION OF THE TRAGOPOGON ORIENTALIS VOLATILE CONSTITUENTS AND ITS BIOLOGICAL ACTIVITY
Authors: Suleimen Yerlan Melsuly , Sissengaliyeva Gulsana Galimzhankyzy , Ishmuratova Margarita Yulaevna , Jalmakhanbetova Roza Ilemisovna 
Published: November 2019

The purpose of this study is the chemical investigation of the composition of Tragopogon orientalis volatile constituents (VC) and studying of its biological activity.
This article presents the results of research on the study of the chemical composition of species Tragopogon, as well as data of antiradical and cytotoxic activity. To study the dried and crushed aboveground part of the plant (leaves, flowers and stems) was taken. The raw material was collected in the flowering phase, growing in Northern Kazakstan. The VC was isolated from the plant of Tragopogon orientalis by hydrodistillation method on the Clevenger type apparatus. The chemical composition of the VC was determined by GC/MS.
The cytotoxic activity of the VC was determined by the survival rate of sea shrimp Artemia salina. VC of T. orientalis in all studied concentrations (1–10 mg ml-1) exhibit acute lethal toxicity - all larvae die. Antiradical activity was determined by the method of colorimetry of free radicals (DPPH). The experimental results showed that the VC of T. orientalis at all tested concentrations (0.1–1.0 mg ml-1) exhibit low antiradical activity compared with the butylhydroxyanisole standard drug.
DEVELOPMENT OF METHODS FOR OBTAINING POLYSACCHARIDES FROM BIRCH LEAVES (BETULA PENDU-LA ROTH., BETULA PUBESCENS EHRH.)
Authors: Rovkina Kseniya Igorevna , Krivoshchekov Sergey Vladimirovich , Guriev Artem Mikhaylovich , Yusubov Mekhman Suleyman ogly , Belousov Mikhail Valer'yevich 
Published: November 2019

The development of a complex technique for the extraction and purification of polysaccharides from birch leaves (Betula pendula Roth.,Betula pubescens Ehrh.) (PSfB) was the purpose of this study. The following characteristics were used as criteria for evaluating the effect of the parameters studied on the production of target substances: yield of PSfB (gravimetric method), protein content (spectrophotometric method), molecular weight distribution (high performance exclusion chromatography) and degree of purification from low molecular weight impurities (LMWI) (IR) spectroscopy).During the experiment, the optimal parameters were determined at various stages of obtaining the PSfB: degree of raw materials grinding – 1.2–3 mm, pH of the extractant (purified water with pH=7), the ratio of raw materials : extractant (1 : 20), extraction temperature (50 °C), temperature and degree of evaporation (50 °C; 4 times), the ratio of concentrate : ethanol (1 : 3) and the method of purification from the LMWI (ultrafiltration).The result of this work is an optimized method for obtaining PSfB, allowing to achieve high yield without loss of product quality (minimum allowable content of low molecular weight impurities with the highest content of high molecular weight fractions).This technique is the basis for the development of laboratory regulations for obtaining an active pharmaceutical substance based on polysaccharides from birch leaves.
DOI-CODI II EXÉRCITO: A EXPERIÊNCIA DE PRESERVAÇÃO DE UM PATRIMÔNIO SENSÍVEL
Authors: LEAL NEVES DEBORAH REGINA 
Published: November 2019

O DOI-CODI, em São Paulo (Brasil) foi um órgão de repressão que funcionou entre 1969 e 1983 e tinha como principal objetivo a perseguição a opositores da Ditadura Civil-Militar (1964-1985). Em 2010, um grupo de entidades de defesa dos Direitos Humanos solicitou a preservação dos prédios como patrimônio cultural do estado de São Paulo. O artigo tem como objetivo discutir o processo que levou à preservação do conjunto de edifícios, abordando os métodos de pesquisa, as discussões teóricas e os conflitos presentes neste caso emblemático.
Adaptive immunity and skin wound healing in amphibian adults
Authors: Franchini Antonella 
Published: November 2019

AbstractRegeneration and repair with scarring of the skin are two different responses to tissue injury that proceed depending on the animal species. Several studies in multiple organisms have shown that the effectiveness of tissue repair gradually decreases with age in most vertebrates, while the molecular and cellular mechanisms underlying the diverse potentials remain incompletely understood. It is clear, however, that immune system actively participates in the whole process and immune-related activities can mediate both negative and positive roles to influence the quality and diversity of tissue response to damage. Compared with innate immunity, our understanding of the significance of adaptive immune cells in normal repair outcome is limited and deserves further investigation. Here, experimental evidence supporting the contribution of lymphocytes and the involvement of lymphoid organs in skin wound healing are discussed, focusing on the findings emerged in adult amphibians, key animal models for tissue repair and regeneration research.
Some rarely reported deep-water macroalgal species from Bonaire, Caribbean Sea, including Verdigellas discoidea sp. nov. (Palmophyllaceae, Chlorophyta) based on submersible collections
Authors: Ballantine David L. , Brooks Barrett L. , Johnson Gabe P. 
Published: November 2019

Abstract
Two rarely reported and one newly described species of benthic marine algae are herein recognized from deep-water habitats at Bonaire, representing the first Caribbean reports of each. Archestenogramma profundum is previously known only from its type collection in Bermuda at 17 m depth and the rarely reported Halymenia integra is known originally from its type locality at Cabo Frio, Brazil. Verdigellas discoidea is newly described on the basis of morphological and molecular evidence. It forms flat circular thalli to 6.5 cm in diameter, measuring to 390 μm thick. The disc-like algae are attached by several small holdfasts on the ventral surface, but the margins are mostly free from their substrata.
Numerical Analysis on Effect of Additional Gas Injection on Characteristics around Raceway in Melter Gasifier
Authors: Kaiping Du , Xiangzhou Gao , Haibo Sun 
Published: November 2019

Abstract
The raceway plays an important role in the mass and heat transportation inside a melter gasifier. Considering that pure oxygen at room temperature instead of hot air is injected into the melter gasifier, a two-dimensional mathematical model at steady state is developed in the current work to describe the effect of the additional gas injection on the characteristics around the raceway in melter gasifier. The results show that a high-speed jet with a highest temperature above 3500 K could be found in front of tuyere. Furthermore, a small scale of gas flow circulation occurs in front of tuyere that results in a more serious thermal damage to tuyere. In order to decrease the gas temperature in the raceway to prevent the blowing-down caused by tuyere damage, the additional gas, including N2, natural gas (NG) and coke oven gas (COG) should be injected through the tuyere. Compared with N2, additional fuel gas injection gives full play to the high temperature reduction advantage of hydrogen. In addition, considering the insufficient hearth heat after injecting NG and the effective utilization of secondary resource, an appropriate amount of COG is recommended to be injected for optimizing blast system.
Unifying Gaussian LWF and AMP Chain Graphs to Model Interference
Authors: Peña Jose M. 
Published: November 2019

AbstractAn intervention may have an effect on units other than those to which it was administered. This phenomenon is called interference and it usually goes unmodeled. In this paper, we propose to combine Lauritzen-Wermuth-Frydenberg and Andersson-Madigan-Perlman chain graphs to create a new class of causal models that can represent both interference and non-interference relationships for Gaussian distributions. Specifically, we define the new class of models, introduce global and local and pairwise Markov properties for them, and prove their equivalence. We also propose an algorithm for maximum likelihood parameter estimation for the new models, and report experimental results. Finally, we show how to compute the effects of interventions in the new models.
Crystal structure of bis(hydroxydi(pyridin-2-yl)methanolato-κ3
N,N′O)cobalt(III) 7,7,8,8-tetracyanoquinodimethane, C34H22CoN8O4
Authors: Huang Junjie , Lu Yang , Lu Hui , Sun Jianhua 
Published: November 2019

Abstract
C34H22CoN8O4, triclinic, P1̄ (no. 2), a = 6.8423(10) Å, b = 8.8919(13) Å, c = 12.6319(18) Å, α = 104.743(2)°, β = 94.606(2)°, γ = 90.934(2)°, V = 740.30(19) Å3, Z = 1, R
gt(F) = 0.0369, wRref(F
2) = 0.1179, T = 296(2) K.