bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reorganization of a Nuclear Medicine Department in Northern Italy During a 2-Month Lockdown for COVID-19 Pandemic
Authors: Maffione Anna Margherita , Chondrogiannis Sotirios , Rampin Lucia , Grassetto Gaia , Marzola Maria Cristina , Bassan Alex , Massaro Arianna , Colletti Patrick M. , Rubello Domenico 
Published: September 2020

Abstract
Coronavirus disease (COVID-19) outbreak has profoundly changed the organization of hospital activities. We present our experience of reorganization of a nuclear medicine service settled in Northern Italy during the pandemic period of March and April 2020 characterized a government-mandated lockdown. Our service remained open during the whole period, performing approximately 80% of the routine practice, while maintaining it COVID-free despite the geographical context characterized by a high risk of infection. Reorganization involved all aspects of a nuclear medicine department, following local, national, and international guidelines for prioritizing patients, telephone and physical triages, deployment of appropriate personal protective equipment, social distancing, and logistic changes for scheduling examinations and disinfection procedures. All staff remained COVID-19–negative despite the unintentional admission of 4 patients who later turned out to be positive for the severe acute respiratory syndrome coronavirus 2. These adopted measures would serve as the basis for safe nuclear medicine services in the post–lockdown phase.
Para-aortal Ganglion Mimicking a Lymph Node Metastases on 68Ga-PSMA PET/CT
Authors: Schweighofer Zwink Gregor , Rendl Gundula , Schmeller Nikolaus , Pirich Christian 
Published: September 2020

Abstract
PSMA-based nuclear medicine imaging impacts increasingly the clinical decision process in prostate cancer patients. A well-known PSMA pitfall is uptake into autonomic ganglia. The intensity of uptake, the shape, and the exact location of the correlating structure in CT are supposed to aid discriminating between ganglia and lymph node metastases. In this patient, we found intense uptake in a nodular shaped para-aortal soft tissue lesion suspicious of a lymph node metastases at staging as well as restaging. After secondary resection, the lesion was histologically proven an autonomic ganglion with intense PSMA expression.
Solitary Hard Palate Langerhans Cell Histiocytosis Demonstrated on PET/CT Scan in an Adult
Authors: Chen Haotian , Fan Qiuping , Su Minggang 
Published: September 2020

Abstract
Langerhans cell histiocytosis (LCH) is rare in adults. Oral and maxillofacial LCH commonly affects the bones of the skull and jaws. Here we report a case of a 57-year-old man with a painless oral mass evaluated by 18F-FDG PET/CT. PET/CT showed a solitary 18F-FDG-avid tumor in his left hard palate. LCH was confirmed after surgery. This case reminds us that LCH should be considered in an adult with hypermetabolic hard palate lesion on 18F-FDG PET/CT.
18F-FDG PET/CT of Hepatosplenic Actinomycosis After Laparoscopic Cystojejunostomy for Pancreatic Pseudocyst
Authors: Zou Qiong , Jiao Ju , Liu Wei-min , Yang Ting , Zhang Yong 
Published: September 2020

Abstract
We report the 18F-FDG PET/CT appearance of abdominal actinomycosis in a 48-year-old immunocompetent woman with a history of laparoscopic cystojejunostomy for pancreatic pseudocyst previously. 18F-FDG PET/CT demonstrated multiple hypermetabolism in the liver, spleen, cystojejunostomy anastomosis, greater omentum, and umbilical region. Actinomycosis was verified by biopsy. Hepatosplenic actinomycosis secondary to cystojejunostomy is extremely rare and easily to be misdiagnosed. PET/CT is helpful for auxiliary diagnosis, guiding biopsy, and exploring the extent of the disease.
FDG PET/CT Findings of Melanoma in a Renal Allograft
Authors: Ran Pengcheng , Huang Leilei , Meng Fanhang , Liu Yupin 
Published: September 2020

Abstract
Renal melanoma is rare. We present a case with FDG-avid melanoma arising from renal allograft. This case indicates that melanoma can occur in the allograft, and it should be considered as a differential diagnosis of focal abnormal FDG uptake in the renal allograft.
68Ga-FAPI and 18F-FDG PET/CT Images in a Patient With Extrapulmonary Tuberculosis Mimicking Malignant Tumor
Authors: Gu Bingxin , Luo Zhiguo , He Xinhong , Wang Jian , Song Shaoli 
Published: September 2020

Abstract
Extrapulmonary tuberculosis (TB) is difficult to diagnose. Here, we report a case of extrapulmonary TB in a 68-year-old woman presented with mental fatigue, poor appetite, and weight loss. 18F-FDG PET/CT revealed elevated 18F-FDG uptake in the left inferior cervical, left supraclavicular, mediastinal, and splenic hilum lymph nodes and spleen, which were suspected of malignant tumor. To further differentiate benign and malignant diseases, 68Ga-FAPI PET/CT was performed. 68Ga-FAPI PET/CT also showed intense 68Ga-FAPI uptake in the previously mentioned FDG-avid lesions. However, biopsy of the left supraclavicular lymph node demonstrated the presence of TB.
Intense Increased 18F-FDG Uptake of Masticator Muscles After Cocaine Use
Authors: Meneret Pierre , Palard-Novello Xavier , Cuvilliers Cécile , Girard Antoine , Pontoizeau Clémence 
Published: September 2020

Abstract

18F-FDG is the most widely used PET tracer worldwide. Before the examination, recommendations are given to patients to avoid muscular activities, with the goal to limit 18F-FDG uptake in muscles. Here, we report the case of a 36-year-old man with Hodgkin disease referred to our department to perform an 18F-FDG PET/CT for immunotherapy assessment. The PET images showed a homogeneous, symmetric, and very intense uptake of the masticatory muscles. The medical examination exhibited a trismus, and the patient revealed to have been using cocaine 15 minutes before injection of 18F-FDG.
18F-FDG PET/CT in Osteoradionecrosis of the Hyoid
Authors: Antippa Sophia Huntley , Du Leanne , Price Nathan , Hsu Charlie Chia-Tsong 
Published: September 2020

Abstract
Osteoradionecrosis (ORN) is a well-documented complication following radiation treatment for head and neck malignancy. Facial bones, mainly the mandible, laryngeal cartilage, and skull, are frequently involved sites for ORN. A rare site for ORN is the hyoid, with very limited cases described in the literature. Recognition of the imaging pattern of hyoid ORN is critical to avoid misdiagnosis of recurrent disease, prompting early treatment.
Necrobiotic Xanthogranuloma on 18F-FDG PET/CT
Authors: Eltilib Mohamed , Fenner Jordan , Saramago Israel , Oldan Jorge 
Published: September 2020

Abstract
We report the case of a 57-year-old man who presented with a 6-year history of yellowish plaques on his left buttock and right medial knee, as well as ulcerating subcutaneous nodules on his forearms bilaterally. Skin biopsy, bone biopsy, and serum protein electrophoresis confirmed the diagnosis of necrobiotic xanthogranuloma with associated monoclonal gammopathy. Necrobiotic xanthogranuloma is a rare form of non-Langerhans histiocytosis characterized by development of chronic cutaneous nodules that enlarge over time to form plaques. The author discusses necrobiotic xanthogranuloma’s presentation and the utility of 18F-FDG PET/CT in disease staging, localizing optimal biopsy sites, and assessing treatment response.
A Keyhole Approach Centered by Anterior Squamous Suture to Hypertensive Basal Ganglia Hemorrhage
Authors: Lin Jianhao , Li Yehai , Ye Jing , Huang Fobao , He Guilu , Li Qiao , Zhang Liang 
Published: September 2020

Objective:
This study aimed to improve the accuracy and efficacy of the keyhole transsylvian approach to remove hypertensive basal ganglia hemorrhage. The authors presented a stable keyhole craniotomy based on anterior squamous suture to expose insular cortex and basal ganglia.

Methods:
Twenty-nine patients with hypertensive basal ganglia hemorrhage were treated with keyhole surgery and studied in Guangdong sanjiu brain hospital.

Results:
By using a bone suture marked keyhole transsylvian approach, near-complete (90%) hematoma evacuation was achieved in 21 cases (72.4), 70% to 90% in 8 cases (24.1), and less than 70% in 1 case (3.4%). In our cohort, 55.1% (16/29) with good function (GOS score 4–5), 41.3% (12/29) with disability (GOS score 3), and 3.4% (1/29) in a vegetative state (GOS score 2). No patients died within 6 months of operation.

Conclusions:
Our method can greatly minimize the bone exposure and precisely located the distal Sylvian fissure. A stable keyhole craniotomy based on bone suture can be identically safe and effective in comparison with classic surgery, and it consumes less time and less intra-operative bleeding.
Diced Cartilage in Fibrin Glue for Dorsal Reconstruction as Part of Staged Paramedian Forehead Flap Reconstruction
Authors: Abdel-Aty Yassmeen , Prasad Navin , Hall Scott R. , Howard Brittany E. 
Published: September 2020

Abstract
The use of diced cartilage grafting is a powerful tool during rhinoplasty for dorsal augmentation; however, its application to nasal structural reconstruction has rarely been reported. Here we present a unique technique for Mohs defect reconstruction combining diced cartilage graft for dorsal augmentation and a folded paramedian forehead flap for soft tissue. A 54-year-old female presented with recurrent basal cell carcinoma of the nose that had been previously resected 3 times in the past. This was treated with Mohs surgery resulting in a through and through nasal defect. This was reconstructed with a staged folded paramedian forehead flap with staged. Due to a loss of dorsal volume and definition creating an excess supratip break, a diced cartilage graft with fibrin glue and temporalis fascia was used for dorsal augmentation. The use of diced cartilage has regained popularity over the last 2 decades with multiple techniques utilizing diced cartilage alone, wrapped in fascia, covered in fascia, wrapped in oxidized methylcellulose, or solidified with fibrin glue. Literature describing the use of fibrin glue suggests that it improves wound healing by promoting cartilage growth, stabilization, and diffusion of nutrients to the graft. Its malleable nature allows for adjustments after the initial placement. This report demonstrates the viability of diced cartilage graft for dorsal augmentation with a paramedian forehead flap for nasal reconstruction. This technique can serve as a powerful tool for the nasal reconstructive surgeon needing scaffolding to rebuild and define the nasal dorsum.
Preparation (mis)perception: effects of involvement on food attributes and desirability
Authors: Lefebvre Sarah , Orlowski Marissa 
Published: September 2020

PurposeThe purpose of this paper is to assess the effect of involvement in food preparation on estimated calorie content, perception of portion size and desirability of the food item.Design/methodology/approachTo test the hypotheses, three between-subjects experiments (one online, two in a laboratory setting) were conducted. Across the three experiments, participants were presented with a food item either ready for consumption (low involvement) or with the individual ingredients in need of assembly prior to consumption (high involvement).FindingsResults showed that when a consumer is involved in the preparation of their food, they perceive the food to be lower in calories and smaller in portion size than when the same food is presented fully prepared and ready-to-eat. In addition, the effect of food preparation involvement on perception of portion size has negative downstream consequences on food desirability, as a smaller perceived portion resulted in a less desirable food item.Originality/valueTo the authors’ knowledge, the results of this research are the first to focus on the impact of preparation involvement on perceptions of the specific product attributes of calorie content and portion size, and the downstream effect on desirability.
The impact of anonymous, two-way, computer-mediated communication on perceived whistleblower credibility
Authors: Young Jacob A. , Courtney James F. , Bennett Rebecca J. , Ellis Timothy Selwyn , Posey Clay 
Published: September 2020

PurposeThe purpose of this study was to investigate the impact of two-way, computer-mediated communication on investigator perceptions of whistleblower credibility.Design/methodology/approachInvestigators were recruited to participate in an online experiment that tasked subjects with evaluating simulated two-way, computer-mediated communication between an investigator and whistleblower. Several rival explanations were also examined to account for potential confounds.FindingsWhile anonymous whistleblowers were perceived to be less credible than identified whistleblowers when reporting via one-way communication, perceived whistleblower credibility was not statistically different when using two-way communication. Further, investigators allocated statistically similar amounts to investigate anonymous and identified reports.Research limitations/implicationsBased upon the results of this study, several new research directions can be explored with respect to maintaining anonymity, assessing credibility and designing reporting systems.Practical implicationsThe results support the use of anonymous, two-way communication in whistleblowing reporting systems. Anonymous whistleblowers would benefit from the ability to maintain an active dialogue with investigators without jeopardizing their safety or the investigation.Social implicationsThis study provides empirical support for strengthening whistleblowing reporting channels through the adoption of anonymous, two-way, computer-mediated communication. Doing so can better preserve the anonymity of those willing to report wrongdoing and better protect them from potential retaliation.Originality/valueThis study is among the first to empirically test the longstanding theory that anonymous reports are perceived by investigators as less credible than those from identified individuals. This study is also among the first to consider and incorporate anonymous, two-way communication in whistleblowing reporting.
Consensus on the definition of social entrepreneurship: a content analysis approach
Authors: Wu Yenchun Jim , Wu Tienhua , Arno Sharpe Jeremiah 
Published: September 2020

PurposeThis study aims to reach academic consensus on key factors and boundaries used in defining the concepts of “social entrepreneurship” (SEsh), “social entrepreneur” (SE), and “social enterprise” (SEV). This study also explores the complex relationships among social/business enterprises, definitional categories and factors, missions, and impacts on effectiveness of practices and organizing for venture success.Design/methodology/approachContent analysis is conducted on articles published from 1998 to 2016 in peer-reviewed academic journals in the fields of management and organization. Furthermore, 80 articles are obtained and analyzed in terms of factors and frequently used terms for unified definitions and their intertwined linkages.FindingsThe unifying factors for the definitions of SEsh, SE, and SEV include primary mission and processes and resources. Strong linkages are observed between SEsh and actors, SE and characteristics, and SEV and organizational form. Results indicate that definitional categories and factors share numerous joint terms that can be used to propose unified definitions. This study identifies the effective interactions of variables among social mission, capabilities to manage resources and processes, entrepreneurial characteristics of actors, and forms of ventures in a process that provides potential for organizational sustainability and impact maximization.Research limitations/implicationsThis paper contributes to research by identifying clear and agreed-upon factors and traits as boundaries to propose definitions that can advance the legitimacy of social entrepreneurship as an academic field worthy of future exploration.Practical implicationsThe findings emphasize social mission that achieves public benefits while preventing mission drift. Economic value and choice of organizational form can advance the fulfillment of objectives and governance practices. This study also presents the key influencing factors at various stages of an entrepreneurial process to determine how these concepts interact to increase the likelihood of organizational emergence and survival.Originality/valueThis work is the first to systematically review management and organizational literature on the key factors and terms that constitute the distinct definitions of SEsh, SE, and SEV and help clarify their complex relations in an entrepreneurial process.
Food tourism: cooking holiday experiences in East Asia
Authors: Chang Janet , Okumus Bendegul , Wang Chih-Hung , Chiu Chien-Yin 
Published: September 2020

Purpose
This study aims to investigate how the “cooking holiday” concept can be used by tourism authorities and practitioners and, to that end, proposes a hierarchical framework for improving culinary tourism.

Design/methodology/approach
This study adopted the Delphi method to filter and verify the criteria, thereby constructing a hierarchical framework of cooking holidays in Taiwan. The analytic hierarchy process (AHP) was also applied to calculate the relative weight of each attribute and criterion, thus identifying their degrees of importance.

Findings
Four attributes (“local food,” “food trail,” “cooking experience” and “environment and atmosphere”) and 22 criteria were identified to comprise a cooking holiday experience framework. Research findings reveal “cooking experience” as the most crucial of the four attributes identified. Of the more numerous criteria, “ingredients with integrity,” “local features” and “diverse curriculum” were identified as the three most important.

Research limitations/implications
The hierarchical framework of cooking holiday experiences can be used by tourism authorities and practitioners to enhance experiential quality for tourists and promote culinary tourism in Taiwan. According to the research findings, cooking class participants can concentrate on the “cooking experience” while emphasizing “ingredients with integrity,” “local features” and “diverse curricula” in the context of cooking holidays.

Originality/value
This study offers valuable insights and suggests directions for future research on culinary tourism. This study also offers a framework for developing cooking holidays.
Variable expression of Van der Woude syndrome: A case report
Authors: Altuntaş Zeynep , Ismayilzade Majid , Altuntaş Mahmut , Yildirim Mehmet E. C. 
Published: September 2020

AbstractVan der Woude syndrome (VWS) is an autosomal dominant disorder with a rare clinical manifestation of orofacial disorders with deletion in the 1q32‐q41 chromosome band. In our study we present a clinical case of a 1‐year old boy with a bilateral cleft lip, a cleft palate and bilateral congenital pits on the lower lip and a father with various clinical presentations of VWS.
Tracing Complexity: The Case of Archaeology
Authors: Dan‐Cohen Talia 
Published: September 2020

ABSTRACTComplexity is everywhere. From biology to genomics, from anthropology to public policy, experts are marveling at the complexity of the phenomena they study. Yet in recent years, scholars have warned against taking all of this complexity at face value. In this spirit, this article frames “complexity” as an epistemic artifact traceable through particular histories and traditions of knowledge‐making. Attributions of relative complexity to different societies have a long history in anthropology. Archaeologists, in particular, have defined and redefined, debated and deconstructed complexity, leaving behind a lively textual trail. Examining this trail as a case study, the article investigates some of the different and sometimes conflicting logics behind what gets to count as complex, when, and why, as well as behind the more general expansion of complexity's reach in recent decades. By doing so, it exemplifies a way of approaching complexity as an anthropological problem and as a dominant problematic of our times. [knowledge, complexity, epistemology, archaeology]
Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response
Authors: Luo H , He J , Qin L , Chen Y , Chen L , Li R , Zeng Y , Zhu C , You X , Wu Y 
Published: September 2020

Summary
Mycoplasma pneumoniae is an obligate pathogen that causes pneumonia, tracheobronchitis, pharyngitis and asthma in humans. It is well recognized that membrane lipoproteins are immunostimulants exerting as lipopolysaccharides (LPS) and play a crucial role in the pathogenesis of inflammatory responses upon M. pneumoniae infection. Here, we report that the M. pneumoniae-derived lipids are another proinflammatory agents. Using an antibody-neutralizing assay, RNA interference or specific inhibitors, we found that Toll-like receptor 4 (TLR-4) is essential for M. pneumoniae lipid-induced tumour necrosis factor (TNF)-α and interleukin (IL)-1β production. We also demonstrate that NLR family pyrin domain containing 3 inflammasome (NLRP3) inflammasome, autophagy and nuclear factor kappa B (NF-κB)-dependent pathways are critical for the secretion of proinflammatory cytokines, while inhibition of TLR-4 significantly abrogates these events. Further characterization revealed that autophagy-mediated inflammatory responses involved the activation of NF-κB. In addition, the activation of NF-κB promoted lipid-induced autophagosome formation, as revealed by assays using pharmacological inhibitors, 3-methyladenine (3-MA) and Bay 11-7082, or silencing of atg5 and beclin-1. These findings suggest that, unlike the response to lipoprotein stimulation, the inflammation in response to M. pneumoniae lipids is mediated by the TLR-4 pathway, which subsequently initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-κB signalling cascade, ultimately promoting TNF-α and Il-1β production in macrophages.
Metabolic and hormonal side effects of mitotane treatment for adrenocortical carcinoma: A retrospective study in 50 Danish patients
Authors: Vikner Malene Elbæk , Krogh Jesper , Daugaard Gedske , Andreassen Mikkel 
Published: September 2020

AbstractObjectiveMitotane is used in the treatment of adrenocortical carcinoma (ACC). Metabolic and hormonal side effects of mitotane, the effect of subsequent treatment with statins and hormones and the effects of discontinuation of mitotane were assessed.Patients and methodsFifty patients were included. Lipid profiles, thyroid hormones, sex hormones and adrenal function from first year of mitotane treatment and after cessation were evaluated.ResultsAfter 6 months of mitotane treatment total cholesterol increased from (median) 5.1 (IQR 4.3 to 5.8) to 7.4 (6.2–9.0) mmol/L, p < .001. LDL, HDL and triglyceride also increased, all p ≤ .03. Three months of treatment with statins decreased total and LDL‐cholesterol, and cessation of mitotane led to further reduction in lipids. Plasma thyroxine decreased from 90 (78–111) to 57 (47–63) nmol/L and free thyroxine from 16.0 (13.0–18.3) to 11.7 (10.5–12.6) pmol/L on mitotane, both p < .001, while TSH remained unchanged. Treatment with thyroxin significantly increased plasma thyroxine and free thyroxine and decreased TSH. Cessation of mitotane increased total T4 (p < .001). Mitotane increased plasma SHBG from 36 (22–51) to 189 (85–259) nmol/L and LH from 4.6 (1.6–8.1) to 20.0 (10.0–34.9) IU/L, both p < .001. In males the changes were accompanied by an increase in testosterone from 9.8 (7.2–14.5) to 27.0 (15.3–34.8) nmol/L, p < .03. Fifteen of 24 tested patients regained normal adrenal function 6 (3–16) months after cessation of mitotane.ConclusionsMitotane treatment exerts multiple severe side effects involving both the metabolic and endocrine systems that may require treatment, but the effect appears to be partially reversible.