bluuebunny/crossref_metadata_2025_split huggingface dataset:
Глобализация образования в системном контексте
Authors: Малинецкий Георгий Геннадьевич , Сиренко Светлана Николаевна 
Published: April 2020

Цитирование: Малинецкий Г.Г., Сиренко С.Н. (2020) Глобализация образования в системном контексте // Мир России. Т. 29. № 2. С. 92–107. DOI: 10.17323/1811-038X-2020-29-2-92-107
В настоящей статье в рамках теории гуманитарно-технологической революции рассматривается роль знания, технологий и образования при переходе от индустриальной к  постиндустриальной фазе развития цивилизации. Мир находится в точке бифуркации, и  изменение отношения к образованию и знанию может определить траекторию как мира в  целом, так и отдельных цивилизаций. Сейчас «финансовая» и «товарная» глобализация переживает кризис, и на первый план выходят глобализационные процессы в сфере образования и технологий, а также проблемы, связанные с климатическими изменениями, исчерпанием ряда ключевых ресурсов и загрязнением окружающей среды. В статье большое внимание уделено анализу результатов исследования PISA для России, Беларуси и других стран постсоветского пространства. Показано, что новая индустриализация и прорыв требуют изменения отношения к знанию, образовательной стратегии и политике. В статье обсуждаются возможные направления модернизации образовательной стратегии Союзного государства.
Pemberdayaan Masyarakat Desa Panti dan Suci melalui Kegiatan Budidaya dan Agribisnis Jamur Tiram dengan Pola Kemitraan untuk Memanfaatkan Waktu Luang
Authors: Wulanjari Distiana 
Published: April 2020

Lokasi Kecamatan Panti yang terletak pada ketinggian antara 180-700 mdpl sangat potensial untuk ditanami tanaman perkebunan seperti kopi. Hal ini berdampak pada mata pencaharian warga sekitar yang bekerja paruh waktu di perkebunan, selain bertani di lahan keluarga. Waktu luang yang cukup leluasa dapat digunakan untuk memberdayakan masyarakat mendapatkan penghasilan tambahan melalui kegiatan budidaya dan agribisnis jamur tiram (mengingat lokasi di kedua desa sangat berpotensi untuk mengembangkan budidaya jamur tiram). Di Desa Panti dan Desa Suci terdapat kelompok jamur tiram yang kurang produktif, sehingga dapat dijadikan mitra untuk membudidayakan jamur tiram di sela-sela waktu luang. Harapannya mitra dapat mandiri membudidayakan jamur tiram sehingga dapat meningkatkan perekonomiannya. Oleh karena itu beberapa bentuk kegiatan dilakukan mulai dari teknik pembuatan baglog jamur, teknik budidaya jamur tiram, pemasaran dan analisis kelayakan usaha budidaya jamur tiram. Sebagai bentuk hilirisasi produk jamur tiram maka dilakukan pula sosialisasi mengenai produk olahan berbasis jamur tiram dengan sasaran ibu-ibu dan pemudi di kedua desa. Produk yang paling diminati warga untuk dikembangkan adalah nugget jamur tiram. Keseluruhan kegiatan tersebut dilakukan pendampingan hingga mitra dapat mandiri. Hasil pengabdian ini mampu menciptakan 10 titik wirausaha yang terdiri dari 4 titik mitra budidaya jamur tiram dan 1 titik mitra olahan jamur tiram di Desa Panti, serta 3 titik mitra budidaya jamur tiram dan 2 titik mitra olahan jamur tiram.
Kata Kunci: Pemberdayaan, Jamur tiram, Kemitraan
Avant-propos
Authors: BOUVAREL I. 
Published: April 2020

Dans un objectif d’amélioration de la compétitivité, les poulets de chair sont sélectionnés sur leur vitesse de croissance et leur efficacité alimentaire. Ces deux critères ont ainsi été multipliés respectivement par 4 et par 3 en 60 ans. La sélection d’animaux capables d’ingérer une grande quantité d’aliment a permis ces gains de productivité, avec différentes conséquences en termes de bien-être animal car les animaux les plus performants sont aussi le plus souvent les plus fragiles. Les citoyens européens se montrent de plus en plus sensibles à la question du bien-être et à la santé des animaux d’élevage. Cette préoccupation sociétale grandissante s’est traduite au niveau communautaire par l’établissement de recommandations au Conseil de l’Europe, et par l’élaboration de Règlements et Directives, au sein de l’Union Européenne, qui fixent des normes applicables aux élevages, aux transporteurs et aux abattoirs. Ces textes incluent un processus auto-évolutif par des révisions régulières, basées sur des rapports d’experts présentant des données scientifiques relatives au bien-être des animaux d’élevage. La directive 2007/43/CE sur le bien-être des poulets de chair a été transposée en droit français par l’arrêté du 28 juin 2010 établissant les normes minimales relatives à la protection des poulets destinés à la production de viande. Ce texte régit les chargements maximum (33, 39 et 42 kg/m²) qui seront accessibles aux éleveurs sous réserve de répondre à plusieurs obligations.
Dans ce contexte particulièrement sensible pour les acteurs de la filière, ce dossier a pour ambition de faire le point sur les différents problèmes de bien-être observés chez le poulet de chair à croissance rapide, aux stades de la reproduction et de la production, et de proposer différentes solutions pour améliorer la robustesse des poulets de chair sans aucune prétention d’exhaustivité.
Nous avons fait le choix d’associer des auteurs de différentes disciplines impliqués plus ou moins directement dans la production afin de confronter les points de vue. Ces travaux ont fait l’objet de présentations lors des dernières Journées de la Recherche Avicole en mars 2011.
Après une présentation des relations entre la génétique et le bien-être du poulet de chair (Arnould et al), Brière et al apportent un aperçu sur les liens complexes entre la nutrition et la fertilité, tant au niveau de l’organisme que des mécanismes cellulaires et moléculaires pouvant être impliqués. Différentes voies nutritionnelles sont envisagées pour améliorer le bien-être des reproducteurs, qui sont dans la pratique restreints. Magnin et Bouvarel montrent ensuite comment la conduite alimentaire permet de limiter chez le poulet de chair en production, l’apparition de troubles locomoteurs, digestifs et métaboliques, avec des possibles marges de progrès via les modalités de distribution des aliments. Enfin, pour pallier une très grande sensibilité des poulets de chair aux pics de chaleur, Collin et al présentent les avantages d’une technique d’acclimatation au stade embryonnaire.
Identify key genes and pathways in pancreatic ductal adenocarcinoma via bioinformatics analysis
Authors: Luo Huatian , Chen Da-qiu , Pan Jing-jing , Wu Zhang-wei , Yang Can , Xu Hao-jie , Xu Shang-hua , Cai Hong-da , Chen Shi , Wang Yao-dong 
Published: April 2020

Abstract
Background: Pancreatic cancer has many pathologic types, among which pancreatic ductal adenocarcinoma (PDAC) is the most common one. Bioinformatics has become a very common tool for the selection of potentially pathogenic genes.Methods: Three data sets containing the gene expression profiles of PDAC were downloaded from the gene expression omnibus (GEO) database. The limma package of R language was utilized to explore the differentially expressed genes (DEGs). To analyze functions and signaling pathways, the Database Visualization and Integrated Discovery (DAVID) was used. To visualize the protein-protein interaction (PPI) of the DEGs ,Cytoscape was performed under the utilization of Search Tool for the Retrieval of Interacting Genes (STRING). With the usage of the plug-in cytoHubba in cytoscape software, the hub genes were found out. To verify the expression levels of hub genes, Gene Expression Profiling Interactive Analysis (GEPIA) was performed. Last but not least, UALCAN analysis online tool was implemented to analyze the overall survival.Results: The 376 DEGs were highly enriched in biological processes including signal transduction, apoptotic process and several pathways, mainly associated with Protein digestion and absorption and Pancreatic secretion pathway. The expression levels of nucleolar and spindle associated protein 1 (NUSAP1) and SHC binding and spindle associated 1 (SHCBP1) were discovered highly expressed in pancreatic ductal adenocarcinoma tissues. NUSAP1 and SHCBP1 had a high correlation with prognosis.Conclusions: The findings of this bioinformatics analysis indicate that NUSAP1 and SHCBP1 may be key factors in the prognosis and treatment of pancreatic cancer.
Computer-assisted Ultrasound Assessment of Plaque Characteristics in Radiation-induced and Non-radiation-induced Carotid Atherosclerosis
Authors: Li Yuanxi , Kwong Dora LW , Wu Vincent WC , Yip Shea-Ping , Law Helen KW , Lee Shara WY , Ying Michael 
Published: April 2020

Abstract
Background

Carotid atherosclerosis is common in post-radiotherapy (post-RT) patients and subjects with cardiovascular risk factors (CVRFs). The associated development of carotid plaques (CPs), particularly unstable plaques, is a major cause of cerebrovascular disease. Therefore, accurate detection and evaluation of CP characteristics is of essence.

This study investigated the feasibility of using a computer-assisted method to evaluate and differentiate the CP characteristics in radiation-induced and non-radiation-induced CA.

Methods

107 post-RT NPC and 110 CVRF subjects were recruited. Each participant had a carotid ultrasound examination of CPs and carotid intima-media thickness (CIMT). The carotid plaque characteristics were evaluated for grey-scale median (GSM) and detailed plaque texture analysis (DPTA) using specific computer software. In DPTA, five different intra-plaque components were color-coded according to different grey scale ranges. Multivariate regression model was used to evaluate the correlation of risk factors and carotid plaque characteristics.

Results

Post-RT NPC patients have significantly higher CIMT (748±15.1µm, p=0.001), more incidence of plaque formation (80.4%, p<0.001) and larger number of plaques (2.3±0.2, p<0.001) than CVRF subjects (680.4±10.0µm, 38.2% and 0.5±0.1 respectively). Among the five intra-plaque components, radiation-induced carotid plaques had significantly larger area of calcification (4.8 ±7.7%, p=0.012), but lesser area of lipid (42.1%±16.9%, p=0.034) when compared to non-radiation-induced CPs (3.0%±5.7% and 46.3%±17.9% respectively). Age, radiation and number of CVRF were significantly associated with the CA burden (p<0.001). Besides, age was significantly associated with the amount of lipid and calcification within CPs (p<0.001).

Conclusions

Compared to CVRF subjects, post-RT NPC patients were more susceptible to carotid plaque formation with less lipid content. Considering both CA burden and plaque component, both post-RT NPC patients and individuals with CVRF have a high risk of cerebrovascular diseases.
Spatial analysis of hypospadias cases in northern France: Taking clinical data into account.
Authors: PREVOST Arthur LAURIOT DIT , GENIN Michael , OCCELLI Florent , PRISO René-Hilaire , BESSON Remi , LANIER Caroline , SHARMA Dyuti 
Published: April 2020

Abstract
Background

Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias in our region, taking into account of clinical data, and evaluate association to socio-economic and ecological data.

Methods

All boys with hypospadias born in northern France and seen in Lille University Medical Center (Lille, France) between 1999 and 2012 were included in the analysis. We retrospectively collected geographic data, clinical data (especially known confounding factors associated with an elevated risk of hypospadias), and demographic, socio-economic and ecological data. We analyzed the whole study population and then the subset of boys lacking confounding factors.

Results

The study sample of 975 cases of hypospadias was characterized by significant spatial heterogeneity (p<0.005) and autocorrelation (p<0.001). We detected two high-incidence clusters that differed with regard to their land use. After the exclusion of 221 patients with confounding factors, two high-incidence clusters with significant disease risks (1.65 and 1.75, respectively; p<0.001) and a significant difference in land use (p<0.001) again appeared. The first cluster contained a higher median [interquartile range] proportion of artificialized land (0.40 [0.22;0.47]) than the remaining “neutral areas” (0.19 [0.08;0.53]) did (p<0.001). Conversely, the second cluster contained a higher median proportion of rural land (0.90 [0.78;0.96]) than the “neutral areas” (0.81 [0.47;0.92]) did (p<0.001). The median deprivation index was significantly lower in the urban cluster (0.47 [0.42;0.55]) and significantly higher in the rural cluster (0.69 [0.56;0.73]) (p<0.001).

Conclusions

Our results evidenced the heterogeneous spatial distribution of cases of hypospadias in northern France. We identified two clusters with different environmental and social patterns – even after the exclusion of known confounding factors.
Proprotein Convertase Subtilisin/Kexin Type 9 in the Inflammation-Related Dyslipidemia of Patients with Axial Spondyloarthritis is Related to Disease Activity.
Authors: Armas-Rillo Laura de , Quevedo-Abeledo Juan Carlos , Vera-González Antonia de , González-Delgado Alejandra , García-Dopico José A. , Jimenez-Sosa Alejandro , Rodríguez-Lozano Carlos , González-Gay Miguel A. , Ferraz-Amaro Iván 
Published: April 2020

Abstract
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that regulates cholesterol metabolism through low-density lipoprotein receptor degradation and that has been linked to cardiovascular risk. The purpose of the present study was to examine whether PCSK9 levels are related to both abnormalities in the lipid profile and the development of severe atherosclerosis that often occurs in patients with axial spondyloarthritis (axSpA). Methods: Cross-sectional study that encompassed 545 individuals; 299 patients with axSpA and 246 statin use-matched controls. PCSK9, lipoproteins serum concentrations and standard lipid profiles were analyzed in patients and controls. Carotid intima-media thickness (cIMT) and carotid plaques were assessed in patients. A multivariable analysis, adjusted for standard cardiovascular risk factors, was performed to evaluate the influence of PCSK9 on axSpA related dyslipidemia and subclinical carotid atherosclerosis.Results: Most lipid panel parameters (total cholesterol, HDL- and LDL-cholesterol, lipoprotein (a) and apoliprotein A1) were significantly lower in axSpA patients than controls. PCSK9 serum levels (beta coef. -44 [95%CI -60- -27] ng/dl, p=0.000) were also downregulated in axSpA patients after fully multivariate adjustment, including other lipid profile-related molecules modifications that the disease generates. Unadjusted higher levels of PCSK9 were associated with carotid plaque in axSpA patients (beta coef. 27 [95%CI 9-45], p=0.003). ASDAS-CRP was found to be independently and significantly related to PCSK9 (beta coef. 10 [95%CI 1-18] ng/dl, p=0.023) after analyzing fully adjusted models that took age, sex, and the rest of lipid profile molecules into account. Whereas patients taking prednisone showed higher serum levels of PCSK9 (55 [95%CI 24-8]) ng/ml, p=0.001), those under anti-TNF alpha therapies exhibited lower levels (beta coef. -26 [95%CI -43- -9], p=0.003).Conclusion: PCSK9 is downregulated in patients with axSpA. Disease activity is positive and significantly related to PSCK9. Anti-TNF-therapy yields reduction in PCSK9 serum levels.
Intratracheal administration of bone marrow c-kit+ cells offered hopes in ameliorating asthmatic pathologies via the control of miRNA-133 and -126
Authors: Rahbarghazi Reza , Keyhanmanesh Rana , Mirershadi Fatemeh , Heiran Hossain , Bagheri Hesam Saghaei , Saberianpour Shirin , Rezabakhsh Aysa , Delkhosh Aref , Bagheri Yasin , Rajabi Hadi , Ahmadi Mahdi 
Published: April 2020

Abstract
Background There are still challenges regarding c-kit+ cells therapeutic outcome in the clinical setting. Here, we examined of c-kit+ cells effect on the alleviation of asthma by modulating miRNAs expression.MethodsTo induce asthma, male rats were exposed to ovalbumin. Bone marrow-derived c-kit+ cells were enriched by MACS. Animals were classified into four groups (each in 6 rats). Control rats received PBS intratracheally; Ovalbumin-sensitized rats received PBS intratracheally; Ovalbumin-sensitized rats received PBS intratracheally containing 3×105 c-kit+ and c-kit- cells. Cells were stained with Dil fluorescent dye to track in vivo condition. Pathological changes were monitored in asthmatic rats after transplantation of c-kit+ and c-kit- cells. Serum levels of IL-4 and INF-γ were measured by ELISA. Transcription of miRNAs (-126 and 133) were assessed by real-time PCR analysis.ResultsPathological examination, Th1 and Th2 associated cytokines fluctuation confirmed the occurrence of asthma in rats indicated by chronic changes and prominent inflammation compared to the control group (p<0.05). Both c-kit+ and c-kit- cells were verified in pulmonary niche. Administration of c-kit positive cells had potential to changes INF-γ/IL-4 ratio and closed to the normal values compared to matched-control asthmatic rats (p<0.05). We also found that c-kit+ cells regulated the expression of miRNA-126 and -133, indicated by increase of miRNA-133 and decrease of miRNA-126 compared to cell-free sensitized groups (p<0.05). c-kit- cells were unable to promote any therapeutic outcomes in asthmatic milieu.ConclusionsIn overall, c-kit+ cells had potential to diminish asthma-related pathologies presumably by controlling the transcription of miRNA-126 and -133.
BRCA1 and BRCA2 mutations in breast and ovarian cancer families from south west Colombia
Authors: Cifuentes-C Laura , Rivera-Herrera Ana Lucia , Barreto Guillermo 
Published: April 2020

Introduction: Breast cancer is the most common neoplasia of women from all over the world especially women from Colombia. 5%­10% of all cases are caused by hereditary factors, 25% of those cases have mutations in the BRCA1/BRCA2 genes.Objective: The purpose of this study was to identify the mutations associated with the risk of familial breast and/or ovarian cancer in a population of Colombian pacific.Methods: 58 high-risk breast and/or ovarian cancer families and 20 controls were screened for germline mutations in BRCA1 and BRCA2, by Single Strand Conformation Polymorphism (SSCP) and sequencing.Results: Four families (6.9%) were found to carry BRCA1 mutations and eight families (13.8%) had mutations in BRCA2. In BRCA1, we found three Variants of Uncertain Significance (VUS), of which we concluded, using in silico tools, that c.81­12C>G and c.3119G>A (p.Ser1040Asn) are probably deleterious, and c.3083G>A (p.Arg1028His) is probably neutral. In BRCA2, we found three variants of uncertain significance: two were previously described and one novel mutation. Using in silico analysis, we concluded that c.865A>G (p.Asn289Asp) and c.6427T>C (p.Ser2143Pro) are probably deleterious and c.125A>G (p.Tyr42Cys) is probably neutral. Only one of them has previously been reported in Colombia. We also identified 13 polymorphisms (4 in BRCA1 and 9 in BRCA2), two of them are associated with a moderate increase in breast cancer risk (BRCA2 c.1114A>C and c.8755­66T>C).Conclusion: According to our results, the Colombian pacific population presents diverse mutational spectrum for BRCA genes that differs from the findings in other regions in the country.
Implementasi Ta’zir Dalam Meningkatkan Kedisiplinan Santri di Pondok Pesantren Al Masruriyyah
Authors: Tasih Amin , Said Ali 
Published: April 2020

Al Masruriyyah Islamic Boarding School is one of the huts of the Tebuireng foundation that is still hungry for discipline in obeying the rules of the cottage. Al Masruriyyah Islamic boarding schools apply ta’zir as a form of consequence for santri who violate the rules of the cottage. This study aims to describe and analyze the implementation of ta’zir in increasing the discipline of santri in Al Masruriyyah Islamic boarding schools. This study uses a qualitative research approach. Data collection techniques using the method of observation, interviews and documentation. The data obtained will be compiled by reducing/summarizing the data, then presenting the data and drawing conclusions. Based on the research shows that: the implementation of ta’zir carried out by the management and has been approved by the supervisor and caregivers for giving ta’zir every 2 weeks. The criteria for the distribution of ta’zir are 3 from the low, medium and heavy according to the mistakes that have been made. The procedure for giving ta’zir (1) is advised, (2) in ta’zir (3) to be called to Ndalem. The impact of the implementation of ta’zir is that there is a better change in the implementation of teaching and learning activities, obeying the rules, and discipline in worship activities to Allah SWT.
Embedded Librarian in an Emergency Department
Authors: Moth Jennifer Lorna 
Published: April 2020

Clinical librarians, knowledge specialists and informationists have been working closely with medical faculties and hospital departments for some years with the aim of mobilizing evidenced-based medical research in the healthcare workplace. However, evidence of the effectiveness of these interventions is limited. This paper describes the initial findings of an embedded clinical librarian project in an emergency department (ED) of a rural NHS hospital. During the trial period 54 information requests were made by ED staff to the librarian and the librarian spent a total of 2600 minutes answering queries representing a considerable time and cost saving to ED department staff. The librarian was able to effectively mobilise evidence at the point-of-need, supporting evidence-based decision making, Continuing Professional Development (CPD) and staff learning. Staff satisfaction with the embedded librarian service was consistently high.