bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival times are similar among patients with peritoneal, hematogenous, and nodal recurrences after curative resections for gastric cancer
Authors: Sawaki Koichi , Kanda Mitsuro , Ito Seiji , Mochizuki Yoshinari , Teramoto Hitoshi , Ishigure Kiyoshi , Murai Toshifumi , Asada Takahiro , Ishiyama Akiharu , Matsushita Hidenobu , Tanaka Chie , Kobayashi Daisuke , Fujiwara Michitaka , Murotani Kenta , Kodera Yasuhiro 
Published: June 2020

AbstractBackgroundThe three dominant recurrence patterns of gastric cancer are peritoneal, hematogenous, and nodal recurrence. Correlation between initial recurrence site and prognosis is poorly understood, particularly after standardization of postoperative S‐1 adjuvant chemotherapy.MethodsWe analyzed a multi‐institutional database of 3484 patients who underwent gastrectomy for gastric cancer between 2010 and 2014. Patients who experienced recurrences after curative gastrectomy classified into peritoneal, hematogenous, or nodal recurrence groups, according to their initial recurrence sites, and their prognoses were compared.ResultsWe included 313 patients in the analysis, of whom 190 patients (63%) were treated with postoperative adjuvant chemotherapy. Pathological disease states were stage I: n = 20 (6%), stage II: n = 62 (20%), and stage III: n = 231 (74%). Patients were categorized into groups by peritoneal (n = 127), hematogenous (n = 123), and nodal (n = 63) recurrence. The peritoneal recurrence group tended to have longer recurrence‐free survival, but shorter post‐recurrence survival, than the other two groups. Median disease‐specific survival after curative resection by group were peritoneal: 25.8 months, hematogenous: 29.0 months, and nodal: 27.8 months (peritoneal vs hematogenous, P = .152; hematogenous vs nodal, P = .955; peritoneal vs nodal, P = .213).ConclusionsPrognoses after curative resection for gastric cancer were similar among patients with peritoneal, hematogenous, or nodal recurrences.
Mathematical Modelling of Bioethanol Fermentation From Glucose, Xylose or Their Combination – A Review
Authors: Nosrati‐Ghods Nosaibeh , Harrison Susan T. L. , Isafiade Adeniyi J. , Leng Tai Siew 
Published: June 2020

AbstractBioethanol fermentation kinetic studies are described with effective aspects of, but not limited to, substrate limitation, oxygen limitation, substrate inhibition, product inhibition, and cell death. The majority of these studies have used Saccharomyces cerevisiae and regular mathematical modelling in the form of unstructured unsegregated kinetic modelling. In this paper, the bioethanol fermentation kinetics of pentoses or hexoses or their combination are reviewed. The modes of culture (e.g., batch and continuous), microorganisms used, process conditions, and equations including various effective aspects are discussed. The kinetic models giving the best fit to the experimental data were proposed by the Ghaly and EL‐Taweel as well as Hjersted and Henson. The results showed better agreement between modelling and experiment on using simpler equations which consider the three important effective aspects: substrate limitation, substrate inhibition and product inhibition when grown in the standard growth medium. However, more complex equations show a better fit when the optimum temperature is unclear, co‐culturing is employed, or when growth conditions deviate from standard media and process conditions.
Reverse remodeling and arrhythmic burden reduction in a patient with an implantable cardioverter defibrillator treated with sacubitril/valsartan: Case report
Authors: Corrado Egle , Saladino Antonino , Morgante Giusy , Mignano Antonino , Nugara Cinzia , Novo Giuseppina , Coppola Giuseppe 
Published: June 2020

AbstractSacubitril/valsartan has been shown to reduce cardiovascular mortality and hospitalizations in patients with HFrEF when compared to enalapril. There are also some evidences of its potential antiarrhythmic effects. We present a report where we found a relation between reverse ventricular remodeling and arrhythmic reduction in a patient treated with sacubitril/valsartan.
Photoelectrochemical CO2 Reduction via Cu2O/CuFeO2 Hierarchical nanorods photocatalyst
Authors: Oh Sang‐Ho , Kang Ho‐Young , Joo Won‐Hyo , Joo Young‐Chang 
Published: June 2020

AbstractAlthough cuprous oxide, Cu2O, has attracted attention as a promising p‐type semiconductor material for carbon dioxide reduction (CO2RR) photocatalysts, serious stability problems have always occurred due to photocorrosion. In this work, we fabricated hierarchical‐structured photocathodes with CuFeO2 on Cu2O nanorods by spray pyrolysis and oxygen‐controlled heat treatment to improve the stability of Cu2O from a thermodynamic perspective. Field‐emission scanning electron microscopy, field‐emission transmission electron microscopy and X‐ray diffraction confirmed that the Cu2O/CuFeO2 hierarchical nanorod structure was successfully fabricated. It was observed that the photocathodes show enhanced stability as the Fe content increases. Therefore, we report that the CuFeO2 layer enhances the stability of the Cu2O nanorod photocathode. A photocathode with a Cu : Fe atomic ratio of 1.52 : 1 has a current density of 1.1 mA/cm2 at 0.35 VRHE even after 10 linear voltage sweep repetitions, a decrease of only 8 % compared to the current density at the first sweep. Additionally, formate and acetate were produced during the CO2RR, exhibiting faradaic efficiencies (FEs) of 21.6 % and 68.6 %, respectively.
Association between anxiety and clinical outcomes in Chinese patients with myocardial infarction in the absence of obstructive coronary artery disease
Authors: He Chao‐Jie , Zhu Chun‐Yan , Han Bin , Hu Hai‐Zhen , Wang Shi‐Jun , Zhai Chang‐Lin , Hu Hui‐Lin 
Published: June 2020

AbstractBackgroundMyocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% ‐ 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association between anxiety and MINOCA outcomes is less clear.HypothesisAnxiety will be associated with clinical outcomes in patients with MINOCA.Methods and ResultsBetween November 2014 and December 2016, 620 hospitalized patients with MINOCA were recruited from a single center. Within 7 days of coronary angiography, anxiety was assessed using the Zung Self‐Rating Anxiety Scale. The primary endpoint was all‐cause mortality; secondary endpoint was any major adverse cardiovascular event (MACE). After 3 years, 87 deaths and 151 MACE had occurred. Kaplan‐Meier curves indicated the unadjusted rates of all‐cause mortality (log‐rank P = .045) and MACE (log‐rank P = .023) were significantly higher in the anxiety group compared with the control group of patients without anxiety. Multivariate Cox regression analysis showed that clinically significant anxiety was an independent prognostic factor for all‐cause mortality as well as MACE (hazard ratio [HR] = 1.547; 95% confidence interval [CI], 1.006‐2.380; P = .047; HR = 1.460; 95% CI, 1.049‐2.031; P = .025; respectively).ConclusionsAnxiety is significantly and independently associated with an increased risk of all‐cause mortality and MACE in patients with MINOCA.
Optimizing patient selection for cytoreductive nephrectomy based on outcomes in the contemporary era of systemic therapy
Authors: McIntosh Andrew G. , Umbreit Eric C. , Holland Levi C. , Gu Cindy , Tannir Nizar M. , Matin Surena F. , Karam Jose A. , Culp Stephen H. , Wood Christopher G. 
Published: June 2020

BackgroundThe management of metastatic renal cell carcinoma (mRCC) has evolved rapidly, and results from the Cancer du Rein Metastatique Nephrectomie et Antiangiogéniques (CARMENA) trial bring into question the utility of cytoreductive nephrectomy (CN). The objective of this study was to examine overall survival (OS) and identify risk factors associated with patients less likely to benefit from CN in the targeted therapy era.MethodsPatients with mRCC undergoing CN from 2005 to 2017 were identified. Kaplan‐Meier methods and Cox proportional hazards regression analyses were used to assess OS and risk‐stratify patients, respectively, on the basis of preoperative clinical and laboratory data.ResultsSix hundred eight patients were eligible with a median follow‐up of 29.4 months. Ninety‐five percent of the patients had an Eastern Cooperative Oncology Group performance status less than or equal to 1, and 70% had a single site of metastatic disease. In a multivariable analysis, risk factors significantly associated with decreased OS included systemic symptoms at diagnosis, retroperitoneal and supradiaphragmatic lymphadenopathy, bone metastasis, clinical T4 disease, a hemoglobin level less than the lower limit of normal (LLN), a serum albumin level less than the LLN, a serum lactate dehydrogenase level greater than the upper limit of normal, and a neutrophil/lymphocyte ratio greater than or equal to 4. Patients were stratified into 3 risk groups: low (fewer than 2 risk factors), intermediate (2‐3 risk factors), and high (more than 3 risk factors). These groups had median OS of 58.9 months (95% confidence interval [CI], 44.3‐66.6 months), 30.6 months (95% CI, 27.0‐35.0 months), and 19.2 months (95% CI, 13.9‐22.6 months), respectively (P < .0001). The median time to postoperative systemic therapy was 45 days (interquartile range, 30‐90 days).ConclusionsPatients with more than 3 risk factors did not seem to benefit from CN. Importantly, OS in this group was equivalent to, if not higher than, OS for patients in the CN plus sunitinib arm of CARMENA, and this raises the possibility that a well‐selected population might benefit from CN.
Contribution of social responsibility to the work involvement of employees
Authors: Blanco‐Gonzalez Alicia , Diéz‐Martín Francisco , Cachón‐Rodríguez Gabriel , Prado‐Román Camilo 
Published: June 2020

AbstractThis research aims to analyze the contribution of social responsibility to the work involvement of employees through its influence on social capital, legitimacy and loyalty and which entail benefits for the organization such as its survival and its competitive advantage. The data for the empirical analysis were obtained through an online survey in the field of higher education. The data was processed using the structural equations technique (PLS‐SEM). The findings show that, social responsibility significantly influences employees' organizational legitimacy. Social responsibility does not have a positive effect on employees' social capital directly, but through legitimacy. Social capital has a positive influence on employees' loyalty. Managers must make the social responsibility actions known to their employees and should involve them in these actions. This study is an original contribution in assessing the positive effects of social responsibility on social capital, legitimacy, and loyalty from the point of view of employees.
Significance of clinical phenomes of patients with COVID‐19 infection: A learning from 3795 patients in 80 reports
Authors: Zhang Linlin , Wang Diane C. , Huang Qihong , Wang Xiangdong 
Published: June 2020

AbstractA new coronavirus SARS‐CoV‐2 has caused outbreaks in multiple countries and the number of cases is rapidly increasing through human‐to‐human transmission. Clinical phenomes of patients with SARS‐CoV‐2 infection are critical in distinguishing it from other respiratory infections. The extent and characteristics of those phenomes varied depending on the severities of the infection, for example, beginning with fever or a mild cough, progressed with signs of pneumonia, and worsened with severe or even fatal respiratory difficulty in acute respiratory distress syndrome. We summarized clinical phenomes of 3795 patients with COVID‐19 based on 80 published reports from the onset of outbreak to March 2020 to emphasize the importance and specificity of those phenomes in diagnosis and treatment of infection, and evaluate the impact on medical services. The data show that the incidence of male patients was higher than that of females and the level of C‐reaction protein was increased as well as most patients' imaging included ground‐glass opacity. Clinical phenomes of SARS‐CoV‐2 infection were compared with those of SARS‐CoV and MERS‐CoV infections. There is an urgent need to develop an artificial intelligence‐based machine learning capacity to analyze and integrate radiomics‐ or imaging‐based, patient‐based, clinician‐based, and molecular measurements‐based data to fight the outbreak of COVID‐19 and enable more efficient responses to unknown infections in future.
Prognostic and predictive value of radiomics signatures in stage I‐III colon cancer
Authors: Dai Weixing , Mo Shaobo , Han Lingyu , Xiang Wenqiang , Li Menglei , Wang Renjie , Tong Tong , Cai Guoxiang 
Published: June 2020

AbstractAccurate identification of patients with poor prognosis after radical surgery is essential for clinical management of colon cancer. Thus, we aimed to develop death and relapse specific radiomics signatures to individually estimate overall survival (OS) and relapse free survival (RFS) of colon cancer patients. In this study, 701 stage I‐III colon cancer patients were identified from Fudan University Shanghai Cancer Center. A total of 647 three‐dimensional features were extracted from computed tomography images. LASSO Cox was used to identify the significantly death‐ and relapse‐associated features and to build death and relapse specific radiomics signatures, respectively. A total of 13 death‐specific and 26 relapse‐specific features were identified from 647 screened radiomics features. The developed signatures can divide patients into two groups with significantly different death (Hazard Ratio (HR): 3.053; 95% CI, 1.78‐5.23; P < .001) or relapse risk (HR: 2.794; 95% CI, 1.87‐4.16; P < .001). Time‐dependent Relative operating characteristic curve showed that the signatures performed better than any other clinicopathological factors in predicting OS (AUC: 0.768; 95% CI, 0.745‐0.791) and RFS (AUC: 0.744; 95% CI, 0.687‐0.801). Further, survival decision curve analyses confirmed the good clinical utility of the two radiomics signatures. In conclusion, we successfully developed death‐ and relapse‐specific radiomics signatures that can accurately predict OS and RFS, which may facilitate personalized treatment.
Platelet immunophenotyping in health and inherited bleeding disorders, a review and practical hints
Authors: Fouassier Marc , Babuty Antoine , Debord Camille , Béné Marie C. 
Published: June 2020

AbstractInherited platelet function disorders are rare hemorrhagic diseases. The gold standard for their exploration is optical aggregometry; however, investigations by flow cytometry (FCM) are being increasingly used. In this review, the physiology of platelets is first recalled, setting the stage for the compartments of platelets that can be apprehended by specific and appropriate labeling. As this requires some pre‐analytical precautions and specific analytical settings, a second part focuses on these characteristic aspects, based on literature and on the authors' experience in the field, for qualitative or quantitative explorations. Membrane labeling with antibodies to CD42a or CD41, respectively, useful to assess the genetic‐related defects of Glanzmann thrombocytopenia and Bernard Soulier syndrome are then described. Platelet degranulation disorders are detailed in the next section, as they can be explored, upon platelet activation, by measuring the expression of surface P‐Selectin (CD62P) or CD63. Mepacrin uptake and release after activation is another test allowing to explore the function of dense granules. Finally, the flip‐flop anomaly related to Scott syndrome is depicted. Tables summarizing possible FCM assays, and characteristic histograms are provided as reference for flow laboratories interested in developing platelet exploration.
Dammed if you do, dammed if you don't: The impact of economic rationalist imperatives on the adaptive capacity of public infrastructure in Brisbane, Australia and Cork, Ireland
Authors: Tangney Peter 
Published: June 2020

AbstractThis paper presents a comparative analysis of catchment management dams in Cork, Ireland and Brisbane, Australia to demonstrate how interactions between municipal government and expert advisors for public infrastructure administration can constrain community climate adaptation. The analysis highlights how neoliberal economic rationalism can appropriate public value choice under the guise of technocratic expertise. Experts are often considered responsible agents for the effective administration of public infrastructure, even when ostensibly technical decisions concerning infrastructure management seem to demand normative, political input. Technocratic administration arising from economic rationalist priorities can thereby exacerbate the hazards presented by climate variability and advancing climate change. Climate risk managers in both cases over‐relied on operating protocols and the expertise of engineers to administer public infrastructure in pursuit of economic priorities. When operating protocols proved insufficient in the face of climate extremes, however, blame was assigned to experts despite their making all available attempts to avert disaster. Through analysis of these cases, the paper discusses the need for normative transparency in expert‐led public administration and better integration of multi‐level governance for climate resilience when pursuing economic rationalist imperatives.
Research on online parameter identification of interior permanent magnet synchronous motor based on augmented robust forgetting factor recursive least square
Authors: Zhou Yafu , Wang Hantao , Lian Jing 
Published: June 2020

AbstractThe high‐performance motor control relies on the accuracy of the interior permanent magnet synchronous motor (IPMSM) parameters. In order to automatically identify the electrical parameters of IPMSM, an online parameter identification method has been developed based on robust adjustable and double tracking error to improve the identification accuracy of IPMSM parameters, which has been verified by both simulation and experiment. Also the torque closed loop was used to check the accuracy and reliability of the parameter identification. On the one hand, the simulation results show that the identification error was less than 10%, decreasing the response time and enhancing the robustness of parameter identification. On the other hand, the experimental results derived from the TC1782‐based platform verify the effectiveness and robustness of the proposed method, above all results indicating that the present identification algorithm has excellent performances of IPMSM drives system and engineering practicability.
An updated long‐term homogenized daily temperature data set for Australia
Authors: Trewin Blair , Braganza Karl , Fawcett Robert , Grainger Simon , Jovanovic Branislava , Jones David , Martin David , Smalley Robert , Webb Vanessa 
Published: June 2020

AbstractA new version of the long‐term Australian temperature data set, known as ACORN‐SAT (Australian Climate Observations Reference Network—Surface Air Temperature), has been developed. ACORN‐SAT includes homogenized daily maximum and minimum temperature data from 112 locations across Australia, encompassing the period from 1910 to the present, with 60 of the locations having data for the full 1910–2018 period. Homogenization is achieved using a percentile‐matching methodology with a number of improvements beyond practices used in previous versions, including more effective detection and removal of potentially inhomogeneous reference stations and an enhanced breakpoint detection methodology. Explicit corrections have also been introduced for a change in instrument screen size, whilst an assessment has found that the transition from manual to automatic instruments and changes in effective response time of automatic instruments have had a negligible impact on the data. Adjustments associated with documented site moves from in‐town to out‐of‐town locations are predominantly negative, particularly for minimum temperature, with other adjustments showing no strong bias towards either positive or negative values. The new data set shows slightly stronger warming (0.12°C per decade in mean temperature over the 1910–2016 period) than either the previous ACORN‐SAT version (0.10°C) or the unhomogenized gridded data (0.08°C), primarily due to more effective treatment of systematic moves of sites out of towns and the removal of a rounding bias in the version 1 methodology.
Focal cerebral ischemia induces changes in oligodendrocytic tau isoforms in the damaged area
Authors: Villa González Mario , Vallés‐Saiz Laura , Hernández Ivó H. , Avila Jesús , Hernández Félix , Pérez‐Alvarez María José 
Published: June 2020

AbstractIschemic stroke is a major cause of death and the first leading cause of long‐term disability worldwide. The only therapeutic strategy available to date is reperfusion and not all the patients are suitable for this treatment. Blood flow blockage or reduction leads to considerable brain damage, affecting both gray and white matter. The detrimental effects of ischemia have been studied extensively in the former but not in the latter. Previous reports indicate that preservation of white matter integrity reduces deleterious effect of ischemia on the brain. Oligodendrocytes are sensitive to ischemic damage, however, some reports demonstrate that oligodendrogenesis occurs after ischemia. These glial cells have a complex cytoskeletal network, including tau, that plays a key role to proper myelination. 4R‐Tau/3R‐Tau, which differ in the presence/absence of Exon 10, are found in oligodendrocytes; but the precise role of each isoform is not understood. Using permanent middle cerebral artery occlusion model and immunofluorescence, we demonstrate that cerebral ischemia induces an increase in 3R‐Tau versus 4R‐Tau in oligodendrocytes in the damaged area. In addition, cellular distribution of Tau undergoes a change after ischemia, with some oligodendrocytic processes showing positive staining for 3R‐Tau. This occurs simultaneously with the amelioration of neurological damage in ischemic rats. We propose that ischemia triggers an endogenous mechanism involving 3R‐Tau, that induces colonization of the ischemic damaged area by oligodendrocytes in an attempt to myelinate‐injured axons. Understanding the molecular mechanism of this phenomenon could pave the way for the design of therapeutic strategies that exploit glial cells for the treatment of ischemia.