bluuebunny/crossref_metadata_2025_split huggingface dataset:
First speckle interferometric measurements of binary stars at the Observatorio Astrofísico Guillermo Haro
Authors: Guerrero C A , Rosales-Ortega F F , Escobedo G , Martínez J , Castillo E , García-Flores P , Nieto-Suárez M A 
Published: May 2020

ABSTRACT
In this paper, we present the first multiband speckle interferometric measurements of binary stars performed using the 2.1 m telescope of the Observatorio Astrofísico Guillermo Haro, Cananea, Sonora, México. We describe here FICCO: Fast Imaging Camera for Cananea Observatory, a new instrument developed to perform speckle observations from the Northern Hemisphere. We tested this new instrument with objects from the Washington Double Star Catalog, that were observed during three runs allocated in 2019. We report 480 astrometric measurements of 138 pairs, with angular separations ranging from 0.06 to 5.76 arcsec, including 347 measurements with separations smaller than 1 arcsec. We estimated a mean error in separation of 14 mas, 1.6° in position angle, and 0.45 mag for the magnitude difference. We confirmed 12 double stars discovered by Hipparcos. Finally, we present a correction to four previously published orbital solutions of visual binaries.
Orbital and superorbital periods in ULX pulsars, disc-fed HMXBs, Be/X-ray binaries, and double-periodic variables
Authors: Townsend L J , Charles P A 
Published: May 2020

ABSTRACT
We present evidence for a simple linear relationship between the orbital period and superorbital period in ultra-luminous X-ray (ULX) pulsars, akin to what is seen in the population of disc-fed neutron star supergiant X-ray binary and Be/X-ray binary systems. We argue that the most likely cause of this relationship is the modulation of precessing hotspots or density waves in an accretion or circumstellar disc by the binary motion of the system, implying a physical link between ULX pulsars and high-mass X-ray binary (HMXB) pulsars. This hypothesis is supported by recent studies of Galactic and Magellanic Cloud HMXBs accreting at super-Eddington rates, and the position of ULX pulsars on the spin period–orbital period diagram of HMXBs. An interesting secondary relationship discovered in this work is the apparent connection between disc-fed HMXBs, ULXs, and a seemingly unrelated group of early-type binaries showing so-called double-periodic variability. We suggest that these systems are good candidates to be the direct progenitors of Be/X-ray binaries.
Phylogenetic Reconstruction Based on Synteny Block and Gene Adjacencies
Authors: Drillon Guénola , Champeimont Raphaël , Oteri Francesco , Fischer Gilles , Carbone Alessandra 
Published: May 2020

Abstract
Gene order can be used as an informative character to reconstruct phylogenetic relationships between species independently from the local information present in gene/protein sequences. PhyChro is a reconstruction method based on chromosomal rearrangements, applicable to a wide range of eukaryotic genomes with different gene contents and levels of synteny conservation. For each synteny breakpoint issued from pairwise genome comparisons, the algorithm defines two disjoint sets of genomes, named partial splits, respectively, supporting the two block adjacencies defining the breakpoint. Considering all partial splits issued from all pairwise comparisons, a distance between two genomes is computed from the number of partial splits separating them. Tree reconstruction is achieved through a bottom-up approach by iteratively grouping sister genomes minimizing genome distances. PhyChro estimates branch lengths based on the number of synteny breakpoints and provides confidence scores for the branches. PhyChro performance is evaluated on two data sets of 13 vertebrates and 21 yeast genomes by using up to 130,000 and 179,000 breakpoints, respectively, a scale of genomic markers that has been out of reach until now. PhyChro reconstructs very accurate tree topologies even at known problematic branching positions. Its robustness has been benchmarked for different synteny block reconstruction methods. On simulated data PhyChro reconstructs phylogenies perfectly in almost all cases, and shows the highest accuracy compared with other existing tools. PhyChro is very fast, reconstructing the vertebrate and yeast phylogenies in &lt;15 min.
Iron deficiency after kidney transplantation
Authors: Vinke Joanna Sophia J , Francke Marith I , Eisenga Michele F , Hesselink Dennis A , de Borst Martin H 
Published: May 2020

Abstract
Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.
Surgical Management of the Trigeminocerebellar Artery in Microvascular Decompression for Trigeminal Neuralgia
Authors: Goto Yukihiro , Inoue Takuro 
Published: May 2020

Abstract

BACKGROUND
The trigeminocerebellar artery (TCA) is a variant branch of the basilar artery supplying the trigeminal nerve root and cerebellar hemisphere, which may contribute to trigeminal neuralgia (TGN). Despite its unique anatomic description, information regarding the preoperative diagnosis and surgical management of TCA is lacking.

OBJECTIVE
To evaluate our preoperative diagnosis of TCA using 3-dimensional (3D) images and surgical management of TGN cases with TCA involvement.

METHODS
We reviewed our 15 patients with TCA involvement (3.3%) among 460 consecutive patients undergoing microvascular decompression for TGN. In this study, all patients were examined using 3D images using GammaPlan (Elekta, Stockholm, Sweden). TCAs were divided into 2 groups based on surgical findings: encircling type and intraneural type. Biographical data, radiological findings, and operative video recordings were reviewed retrospectively. Surgical outcomes and follow-up were assessed and compared between the 2 groups.

RESULTS
TCA involvement was confirmed preoperatively in 14 of the 15 patients using 3D images. All patients were operated with our unique transposition technique and became pain free immediately after the surgery. Pain-free status was maintained during the follow-up period (3.5 ± 2.6 yr) in all patients but one in whom pain recurred 4 yr after the initial surgery. Re-exploration revealed an adhesion between the Teflon felt and the nerve root.

CONCLUSION
Although TCA involvement is rare, an accurate preoperative diagnosis is essential because the decompression technique may differ from those used for other common cases. Scrutinizing anatomically rare variation with 3D images is recommended for predicting TCA involvement.
The Conserved and Particular Roles of the R2R3-MYB Regulator FhPAP1 from Freesia hybrida in Flower Anthocyanin Biosynthesis
Authors: Li Yueqing , Shan Xiaotong , Tong Linna , Wei Chao , Lu Keyu , Li Shuying , Kimani Shadrack , Wang Shucai , Wang Li , Gao Xiang 
Published: May 2020

Abstract
Anthocyanin biosynthesis is mainly controlled by MYB–bHLH–WD40 (MBW) complexes that modulate the expression of anthocyanin biosynthetic genes (ABGs). The MYB regulators involved in anthocyanin biosynthesis arose early during plant evolution and thus might function divergently in different evolutionary lineages. Although the anthocyanin-promoting R2R3-MYB regulators in eudicots have been comprehensively explored, little consensus has been reached about functional discrepancies versus conservation among MYB regulators from different plant lineages. Here, we integrated transcriptome analysis, gene expression profiles, gain-of-function experiments and transient protoplast transfection assays to functionally characterize the monocot Freesia hybrida anthocyanin MYB regulator gene FhPAP1, which showed correlations with late ABGs. FhPAP1 could activate ABGs as well as TT8-clade genes FhTT8L, AtTT8 and NtAN1 when overexpressed in Freesia, Arabidopsis and tobacco, respectively. Consistently, FhPAP1 could interact with FhTT8L and FhTTG1 to form the conserved MBW complex and shared similar target genes with its orthologs from Arabidopsis. Most prominently, FhPAP1 displayed higher transactivation capacity than its homologs in Arabidopsis and tobacco, which was instantiated in its powerful regulation on ABGs. Moreover, we found that FhPAP1 might be the selected gene during the domestication and rapid evolution of the wild Freesia species to generate intensive flower pigmentation. These results showed that while the MBW complex was highly evolutionarily conserved between tested monocot and core eudicot plants, participating MYB regulators showed functional differences in transactivation capacity according to their activation domain and played important roles in the flower coloration domestication and evolution of angiosperms.
Maintaining High-Quality Multidisciplinary Pain Medicine Fellowship Programs: Part II: Innovations in Clinical Care Workflow, Clinical Supervision, Job Satisfaction, and Postgraduation Mentorship for Pain Fellows During the COVID-19 Pandemic
Authors: Kohan Lynn , Sobey Christopher , Wahezi Sayed , Brancolini Scott , Przkora Rene , Shaparin Naum , Spektor Boris , Moeschler Susan , Anitescu Magdalena 
Published: May 2020

Abstract

Background
Pain fellowship programs are facing unique challenges during the COVID-19 pandemic. Restrictions by state governments and the Centers for Disease Control and Prevention have resulted in a rapidly changing and evolving learning environment for today’s fellows. Innovative solutions must be sought to maintain proper education and ensure the well-being of our trainees.

Methods
We assembled a panel of pain program directors who serve as officers/board members of the Association of Pain Program Directors, offering guidance and recommendations to pain fellowship directors nationwide. Panel members evaluate the best available evidence and expert opinion on use of remote and virtual platforms in clinical care, adaptability to alterations in clinic and referral management, and provide guidance on postgraduate impact.

Conclusions
The country is in the midst of an unprecedented pandemic. The impact on pain management fellowships has been significant and will likely last for months, resulting in extraordinary challenges to the administration of pain fellowship programs and the education of our fellows. Several strategies will help address these challenges, including employing telehealth capabilities to continue clinical experiences and providing trainees with opportunities to continue their professional growth beyond fellowship completion. Together, we can implement innovative solutions to overcome these challenges.
Striving to Rollback or Protect Roe: State Legislation and the Trump-Era Politics of Abortion
Authors: Wilson Joshua C 
Published: May 2020

AbstractAbortion’s centrality to the Christian Right, together with that movement’s importance to Republican Party politics, as well as the policy realities of abortion, have all combined to make regulating abortion a fixture within U.S. state politics for decades. While the levels and forms of state activity have varied since the 1980s, the Trump presidency has produced strategic changes in the content and perceived importance of abortion policy. Notably, recent changes in the state politics of abortion have not just been on the side of Republican states restricting abortion access, the most traditional and highest profile form of policy activity in this area, but have also taken the form of Democratic states actively defending abortion access. This article provides an overview of the interrelated changes in party politics, perceptions of political opportunities, and the content of state abortion regulations. It concludes that the frequency of state abortion laws has increased modestly during the Trump presidency, but substantive shifts in recent policies create the potential to fundamentally reorganize state and national abortion politics.
Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care
Authors: Powers Albert R , van Dyck Laura I , Garrison Jane R , Corlett Philip R 
Published: May 2020

Abstract
Hallucinations—while often considered an indication of mental illness—are commonly experienced by those without a need for clinical care. These nonclinical voice-hearers offer an opportunity to investigate hallucinations in the absence of confounds inherent to the clinical state. Recent work demonstrates an association between auditory verbal hallucinations (AVH) and structural variability in paracingulate sulcus (PCS) of medial prefrontal cortex in a clinical population. However, before PCS length may be considered a biomarker for clinical hallucination risk, it is necessary to investigate PCS structure in a nonclinical population of voice-hearers with AVH phenomenology similar to those of their clinical counterparts. In the current study, PCS length was measured from T1-weighted structural MRI scans of four groups of participants: (1) voice-hearers with a psychotic disorder (n = 15); (2) voice-hearers without a psychotic disorder (n = 15); (3) nonvoice-hearers with a psychotic disorder (n = 14); and (4) nonvoice-hearers without a psychotic disorder (n = 15). There was a main effect of AVH status—but not psychosis—on right PCS length, with no interaction of AVH and psychosis. Participants with AVH exhibited reduced right PCS length compared to participants without AVH (mean reduction = 8.8 mm, P &lt; 0.05). While past studies have demonstrated decreased PCS length in clinical voice-hearers, ours is the first demonstration that shorter right PCS extends to nonclinical voice-hearers. Our findings support the hypothesis that differences in PCS length are related to the propensity to hear voices and not to illness, consistent with a continuum model of voice-hearing.
Privacy protection in Hungary
Authors: Menyhei Ákos , Zsoldos János 
Published: May 2020

Abstract
The EU beneficial ownership register leaves very little room for maneuver for those who prefer to maintain their privacy in present times. This article discusses the privacy element of the Hungarian Asset Management Foundation (AMF), analyzes the impact of the AMF law on the privacy of the participants in an AMF, and gives an insight into the workings of a hybrid structure when an AMF acts as trustee.
Tracing Back the Temporal Change of SARS-CoV-2 with Genomic Signatures
Authors: Biswas Sourav , Saha Suparna , Bandyopadhyay Sanghamitra , Bhattacharyya Malay 
Published: May 2020

AbstractThe coronavirus disease (COVID-19) outbreak starting from China at the end of 2019 and its subsequent spread in many countries have given rise to thousands of coronavirus samples being collected and sequenced till date. To trace back the initial temporal change of SARS-CoV-2, the coronavirus implicated in COVID-19, we study the limited genomic sequences that were available within the first couple of months of its spread. These samples were collected under varying circumstances and highlight wide variations in their genomic compositions. In this paper, we explore whether these variations characterize the initial temporal change of SARS-CoV-2 sequences. We observe thatn-mer distributions in the SARS-CoV-2 samples, which were collected at an earlier period of time, predict its collection timeline with approximately 78% accuracy. However, such a distinctive pattern disappears with the inclusion of samples collected at a later time. We further observe that isolation sources (e.g., oronasopharynx, saliva, feces, etc.) could not be predicted by then-mer patterns in these sequences. Finally, the phylogenetic and protein-alignment analyses highlight interesting associations between SARS-CoV-2 and other coronaviruses.
Performance & Quality Evaluation of Marketed COVID-19 RNA Detection Kits
Authors: Kapitula David Surace , Jiang Zhuopu , Jiang Jianhao , Zhu Jing , Chen Xiangyong , Lin Claudia Qiao 
Published: May 2020

AbstractCompared to other coronaviruses, COVID-19 has a longer incubation period and features asymptomatic infection at a high rate (>25%)1,2. Therefore, early detection of infection is the key to early isolation and treatment. Direct detection of the virus itself has advantages over indirect detection. Currently, the most sensitive and commercially validated method for COVID-19 testing is RT-qPCR, designed to detect amplified virus-specific RNA. Reliable testing has proven to be a bottleneck in early diagnosis of virus infection in all countries dealing with the pandemic. Significant performance and quality issues with available testing kits have caused confusion and serious health risks. In order to provide better understanding of the Quality and performance of COVID-19 RNA detection kits on the market, we designed a system to evaluate the specificity (quantitation), sensitivity (LOD) and robustness of the kits using positive RNA and pseudovirus controls based on COVID-19 genomic sequence3,4. We evaluated 8 Nucleic Acid qPCR Kits approved in China, some of which are also approved in the US and EU. Our study showed that half of these 8 kits lack 1:1 linear relationship for virus RNA copy: qPCR signal. Of the 4 with linear response, 2 demonstrated sensitivity at 1 Copy viral RNA/Reaction, suitable for early detection of virus infection. Furthermore, we established the best RNA extraction, handling and qPCR procedures allowing highly sensitive and consistent performance using BGI qPCR kits. Our study provides an effective method to assess and compare performance quality of all COVID-19 nucleic acid testing kits, globally.Significance StatementTesting for COVID-19 has been a critical topic in the pandemic management since the first outbreak reported in China, and now globally. Despite of focused efforts from global biomedical industries and regulatory authorities, testing tools currently available on the market are not satisfying the huge and most important needs for virus control, which is specific, sensitive, affordable, and commercially viable early diagnosis of infected populations. We have designed an experimental system to assess and compare all nucleic acid-based COVID-19 testing kits from quality control perspectives. The results reported here demonstrate the suitability of using our system as an objective QC system for all commercial kits, including any future kits. We also identified the best testing method using commercially available reagents.
High frequency of SARS-CoV-2 RNAemia and association with severe disease
Authors: Hogan Catherine A. , Stevens Bryan , Sahoo Malaya K. , Huang ChunHong , Garamani Natasha , Gombar Saurabh , Yamamoto Fiona , Murugesan Kanagavel , Kurzer Jason , Zehnder James , Pinsky Benjamin A. 
Published: May 2020

AbstractBackgroundDetection of SARS-CoV-2 RNA in the blood, also known as RNAemia, has been reported, but its prognostic implications are not well understood. This study aimed to determine the frequency of SARS-CoV-2 RNA in plasma and its association with the clinical severity of COVID-19.MethodsAn analytical cross-sectional study was performed in a single-center tertiary care institution in northern California and included consecutive inpatients and outpatients with COVID-19 confirmed by detection of SARS-CoV-2 RNA in nasopharyngeal swab specimens. The prevalence of SARS CoV-2 RNAemia and the strength of its association with clinical severity variables were examined and included the need for transfer to an intensive care unit (ICU), mechanical ventilation and 30-day all-cause mortality.ResultsPaired nasopharyngeal and plasma samples were included from 85 patients. The overall median age was 55 years, and individuals with RNAemia were older than those with undetectable SARS-CoV-2 RNA in plasma (63 vs 50 years; p=0.001). Comorbidities were frequent including obesity (37.7%), hypertension (30.6%) and diabetes mellitus (22.4%). RNAemia was detected in a total of 28/85 (32.9%) individual patients, including 22/28 (78.6%) who required hospital admission. RNAemia was detected more frequently in individuals who developed severe disease including the need for ICU transfer (32.1% vs 14.0%; p=0.05), mechanical ventilation (21.4% vs 3.5%; p=0.01) and 30-day all-cause mortality (14.3% vs 0%; p=0.01). No association was detected between RNAemia and estimated levels of viral RNA in the nasopharynx. An additional 121 plasma samples from 28 individuals with RNAemia were assessed longitudinally, and RNA was detected for a maximum duration of 10 days.ConclusionThis study demonstrated a high proportion of SARS-CoV-2 RNAemia, and an association between RNAemia and clinical severity suggesting the potential utility of plasma viral testing as a prognostic indicator for COVID-19.
Clinical presentation and evolution of COVID-19 in immunosuppressed patients. Preliminary evaluation in a North Italian cohort on calcineurin-inhibitors based therapy
Authors: Cavagna Lorenzo , Bruno Raffaele , Zanframundo Giovanni , Gregorini Marilena , Seminari Elena , Di Matteo Angela , Rampino Teresa , Montecucco Carlomaurizio , Pelenghi Stefano , Cattadori Barbara , Pattonieri Eleonora Francesca , Vitulo Patrizio , Bertani Alessandro , Sambataro Gianluca , Vancheri Carlo , Bonetto Valentina , Monti Maria Cristina , Ticozzelli Elena , Turco Annalisa , Oggionni Tiberio , Corsico Angelo , Codullo Veronica , Morosini Monica , Gnecchi Massimiliano , Pellegrini Carlo , Meloni Federica 
Published: May 2020

ABSTRACTThe clinical course of COVID-19 in patients undergoing chronic immunosuppressive therapy is yet poorly known. We performed a monocentric cross-sectional study describing the clinical course of COVID-19 in a cohort of patients from northern Italy treated with calcineurin-inhibitors for organ transplantation or rheumatic diseases. Data were collected by phone call and clinical chart review between March 27th- 31st2020. COVID-19 related symptoms, rynopharingeal swab, therapeutic changes and outcome were assessed in 384 consecutive patients (57% males; median age 61 years, IQR 48-69). 331 patients (86%) received solid organ transplantation (kidney n=140, 36%, heart n=100, 26%, lung n=91, 24%) and 53 (14%) had a rheumatic disease. Calcineurin inhibitors were the only immunosuppressant administered in 46 patients (12%). 14 patients developed a “confirmed COVID-19” (swab positivity) and 14 a “clinical COVID-19” (only typical symptoms). Fever (75%) and diarrhoea (50%) were the most common symptoms. Fourteen patients were hospitalized and 11 have already been dismissed. No patient required start/changes of the O2 therapy or developed superinfection. Only one patient, with metastatic lung cancer, died. In conclusion, COVID-19 showed a mild course in our cohort, with low mortality. Calcineurin inhibitor-based immunosuppressive regimens appear safe in this context and should not be discontinued.
Fitting SIR model to COVID-19 pandemic data and comparative forecasting with machine learning
Authors: Baldé Mouhamadou A.M.T. 
Published: May 2020

AbstractIn this work, we use a classical SIR model to study COVID-19 pandemic. We aim, to deal with the SIR model fitting to COVID-19 data by using different technics and tools. We particularly use two ways: the first one start by fitting the total number of the confirmed cases and the second use a parametric solver tool. Finally a comparative forecasting, machine learning tools, is given.