bluuebunny/crossref_metadata_2025_split huggingface dataset:
The AGN dependence on cluster mass
Authors: Koulouridis Elias ,   and the XXL collaboration
Published: April 2020

AbstractWe present the results of a study of the AGN density in a homogeneous and well studied sample of 167 bona-fide X-ray galaxy clusters (0.1<z<0.5). Our aim is to study the AGN activity in 167 XXL X-ray galaxy clusters as a function of the cluster mass and the location of the AGN in the cluster. We report a significant AGN excess in our low-mass cluster sub-sample between 0.5r500 and 2r500. In contrast, the high-mass sub-sample presents no AGN excess. The AGN excess in poor clusters indicates AGN triggering, supporting previous studies that reported enhanced galaxy merging in the cluster outskirts. This effect is probably prevented by high velocity dispersions in high-mass clusters. Comparing also with previous studies of massive or high-redshift clusters, we conclude that the AGN fraction in cluster galaxies anti-correlates strongly with cluster mass.
Deep Chandra observations of the core of the Perseus cluster
Authors: Sanders Jeremy S. 
Published: April 2020

AbstractThe Perseus cluster is the X-ray brightest cluster in the sky and with deep Chandra observations we are able to map its central structure on very short spatial scales. In addition, the high quality of X-ray data allows detailed spatially-resolved spectroscopy. In this paper I review what these deep observations have told us about AGN feedback in clusters, sloshing and instabilities, and the metallicity distribution.
The Hot Universe with XRISM and Athena
Authors: Guainazzi M. , Tashiro M. S. 
Published: April 2020

AbstractX-ray spectroscopy is key to address the theme of “The Hot Universe”, the still poorly understood astrophysical processes driving the cosmological evolution of the baryonic hot gas traceable through its electromagnetic radiation. Two future X-ray observatories: the JAXA-led XRISM (due to launch in the early 2020s), and the ESA Cosmic Vision L-class missionAthena(early 2030s) will provide breakthroughs in our understanding of how and when large-scale hot gas structures formed in the Universe, and in tracking their evolution from the formation epoch to the present day.
300-GHz-band wireless communication using a low phase noise photonic source
Authors: Yi L. , Iwamoto K. , Yamamoto T. , Ayano F. , Rolland A. , Kuse N. , Fermann M. , Li Y. , Nagatsuma T. 
Published: April 2020

AbstractThe implementation of advanced multi-level modulation schemes such as quadrature phase-shift keying (QPSK) in contrast to the conventional on–off keying is crucial to further boost the terahertz (THz) communications speed. Thereby, carrier phase noise reduction in the THz range is one of the key goals that need to be urgently achieved. In this paper, the photonic-based THz sources and the phase noise problem are briefly summarized. Then, a low phase-noise photonic source based on the stimulated Brillouin scattering (SBS) optical fiber cavity is first applied for a 300-GHz-band QPSK wireless communication link. The highest data rate at forward-error-correction limited condition was 15 Gbaud utilizing the SBS-based photonic source with a small transmit power of ~ −36 dBm. Its transmission characteristics are evaluated and compared with the conventional optical frequency comb generator (OFCG)-based source at 5 Gbaud. The proposed SBS-based photonic source has been proven to offer better performances than the OFCG-based source with respect to the phase noise, optical carrier to noise ratio, and bit error rate in communications.
Concurrent Observations Of Magnetic Reconnection From Cluster, IMAGE and SuperDARN: A Comparison Of Reconnection Rates And Energy Conversion
Authors: Matar J. , Hubert B. , Yao Z. , Guo R. , Cowley S. W. H. , Milan S. E. , Gurgiolo C. 
Published: April 2020

AbstractAuroral emissions reflect energy dissipation in the atmosphere, while the energy mostly originates from the magnetospheric dynamics of the planet. In the Earth's magnetosphere, the interaction between the solar wind and the terrestrial magnetic field produces magnetic reconnection ultimately causing the appearance of auroras in the polar regions. In this study, we revisit two reconnection events previously identified using ESA Cluster observations during conditions of moderate geomagnetic activity, in the magnetotail. We compare these in situ detections with simultaneous global auroral images from the NASA‐IMAGE satellite and ionospheric convection measurements from SuperDARN. We show for the first time a direct correspondence between the electric voltage estimated at ionospheric altitude and the reconnection rate at the reconnection site. We compute the total auroral precipitation power and compare it to the energy released from the reconnection site. We deduce that the precipitated electron power of the aurora and the electron energy deposition rate from the reconnection site are of the same order of magnitude, which means that the thermal energy released by reconnection is primarily transferred to the ionosphere and contributes to the auroral activity.
Ambient Aerosol Hygroscopic Growth From Combined Raman Lidar and HSRL
Authors: Dawson K. W. , Ferrare R. A. , Moore R. H. , Clayton M. B. , Thorsen T. J. , Eloranta E. W. 
Published: April 2020

AbstractLidar retrievals of aerosol extinction and collocated relative humidity (RH) were acquired during the Department of Energy Combined High Spectral Resolution Lidar (HSRL) and Raman Measurement Study campaign in the summer of 2015 at the Southern Great Plains site in northern Oklahoma. Measurements of the hygroscopic properties of aerosols are crucial for accurately representing their relationship with clouds, which can be a significant source of uncertainty in assessing direct and indirect radiative effects. The ability for lidar to retrieve measurements of the vertically resolved f (RH), that is, the aerosol extinction at some wet RH normalized by the aerosol extinction at a dry reference RH, is investigated here and compared with nephelometer‐measured f (RH) at the surface. We introduce a modified approach to fitting the lidar measurements of aerosol extinction and our comparisons reveal that lidar and nephelometer measurements of f (RH) are consistent, both with each other and with reported values in the literature. The implications for this work present a path forward for global‐scale retrievals of remotely sensed aerosol hygroscopic properties. Most importantly, the efforts in this study could lead to closing the gap on uncertainties associated with the aerosol indirect radiative effect when combined with inversion retrievals of aerosol microphysical properties.
Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-β/Smad3 signaling in melanoma cells
Authors: Bao Yong , Ding Zhi , Zhao Peng , Li Jun , Chen Ping , Zheng Jie , Qian Zhongming 
Published: April 2020

AbstractAccumulating evidence demonstrated that alteronol, a novel compound that has a similar structure with paclitaxel, exerts anticancer effects against diversified tumors. However, whether alteronol induces autophagy and the relationship between its anticancer effects and autophagy in melanoma remains elusive. In this study, we show that alteronol induces not only anti-proliferation activity and apoptosis but also autophagy in A375 and UACC62 cells. In addition, alteronol inhibits A375 and UACC62 cells invasion and migration by preventing the epithelial–mesenchymal transition (EMT). Blocking autophagy enhances alteronol-induced apoptosis and anti-EMT effects in vitro and in vivo. Mechanistically, we find that alteronol significantly inhibits Akt/mTOR and TGFβ/Smad3 pathways, and co-treatment with autophagy inhibitor 3-MA further potentiate these effects. Our results suggest that alteronol induces cyto-protective autophagy in melanoma cells through inhibition of Akt/mTOR pathway, thus attenuates apoptosis and promotes melanoma cell EMT through TGF-β/Smad3 pathway. Combination with alteronol and autophagy inhibitor 3-MA may be a potential treatment for melanoma as it not only significantly inhibited tumor growth but also suppressed tumor invasion and migration as anti-metastasis agent.
Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
Authors: Djomehri Sabra I. , Gonzalez Maria E. , da Veiga Leprevost Felipe , Tekula Shilpa R. , Chang Hui-Yin , White Marissa J. , Cimino-Mathews Ashley , Burman Boris , Basrur Venkatesha , Argani Pedram , Nesvizhskii Alexey I. , Kleer Celina G. 
Published: April 2020

AbstractMetaplastic breast carcinoma (MBC) is a highly aggressive form of triple-negative cancer (TNBC), defined by the presence of metaplastic components of spindle, squamous, or sarcomatoid histology. The protein profiles underpinning the pathological subtypes and metastatic behavior of MBC are unknown. Using multiplex quantitative tandem mass tag-based proteomics we quantify 5798 proteins in MBC, TNBC, and normal breast from 27 patients. Comparing MBC and TNBC protein profiles we show MBC-specific increases related to epithelial-to-mesenchymal transition and extracellular matrix, and reduced metabolic pathways. MBC subtypes exhibit distinct upregulated profiles, including translation and ribosomal events in spindle, inflammation- and apical junction-related proteins in squamous, and extracellular matrix proteins in sarcomatoid subtypes. Comparison of the proteomes of human spindle MBC with mouse spindle (CCN6 knockout) MBC tumors reveals a shared spindle-specific signature of 17 upregulated proteins involved in translation and 19 downregulated proteins with roles in cell metabolism. These data identify potential subtype specific MBC biomarkers and therapeutic targets.
In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy
Authors: Liu Yannan , Wang Hao , Li Shanlong , Chen Chuanshuang , Xu Li , Huang Ping , Liu Feng , Su Yue , Qi Meiwei , Yu Chunyang , Zhou Yongfeng 
Published: April 2020

AbstractVesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π–π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.
Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
Authors: Liedgens Linda , Zimmermann Jannik , Wäschenbach Lucas , Geissel Fabian , Laporte Hugo , Gohlke Holger , Morgan Bruce , Deponte Marcel 
Published: April 2020

AbstractClass I glutaredoxins are enzymatically active, glutathione-dependent oxidoreductases, whilst class II glutaredoxins are typically enzymatically inactive, Fe-S cluster-binding proteins. Enzymatically active glutaredoxins harbor both a glutathione-scaffold site for reacting with glutathionylated disulfide substrates and a glutathione-activator site for reacting with reduced glutathione. Here, using yeast ScGrx7 as a model protein, we comprehensively identified and characterized key residues from four distinct protein regions, as well as the covalently bound glutathione moiety, and quantified their contribution to both interaction sites. Additionally, we developed a redox-sensitive GFP2-based assay, which allowed the real-time assessment of glutaredoxin structure-function relationships inside living cells. Finally, we employed this assay to rapidly screen multiple glutaredoxin mutants, ultimately enabling us to convert enzymatically active and inactive glutaredoxins into each other. In summary, we have gained a comprehensive understanding of the mechanistic underpinnings of glutaredoxin catalysis and have elucidated the determinant structural differences between the two main classes of glutaredoxins.
High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation
Authors: He Wei , Xu Jinzhi , Mu Ruoyu , Li Qiu , Lv Da-lun , Huang Zhen , Zhang Junfeng , Wang Chunming , Dong Lei 
Published: April 2020

AbstractHigh-salt diets are associated with an elevated risk of autoimmune diseases, and immune dysregulation plays a key role in cancer development. However, the correlation between high-salt diets (HSD) and cancer development remains unclear. Here, we report that HSD increases the local concentration of sodium chloride in tumour tissue, inducing high osmotic stress that decreases both the production of cytokines required for myeloid-derived suppressor cells (MDSCs) expansion and MDSCs accumulation in the blood, spleen, and tumour. Consequently, the two major types of MDSCs change their phenotypes: monocytic-MDSCs differentiate into antitumour macrophages, and granulocytic-MDSCs adopt pro-inflammatory functions, thereby reactivating the antitumour actions of T cells. In addition, the expression of p38 mitogen-activated protein kinase-dependent nuclear factor of activated T cells 5 is enhanced in HSD-induced M-MDSC differentiation. Collectively, our study indicates that high-salt intake inhibits tumour growth in mice by activating antitumour immune surveillance through modulating the activities of MDSCs.
Highly efficient electrosynthesis of hydrogen peroxide on a superhydrophobic three-phase interface by natural air diffusion
Authors: Zhang Qizhan , Zhou Minghua , Ren Gengbo , Li Yawei , Li Yanchun , Du Xuedong 
Published: April 2020

AbstractHydrogen peroxide (H2O2) synthesis by electrochemical oxygen reduction reaction has attracted great attention as a green substitute for anthraquinone process. However, low oxygen utilization efficiency (<1%) and high energy consumption remain obstacles. Herein we propose a superhydrophobic natural air diffusion electrode (NADE) to greatly improve the oxygen diffusion coefficient at the cathode about 5.7 times as compared to the normal gas diffusion electrode (GDE) system. NADE allows the oxygen to be naturally diffused to the reaction interface, eliminating the need to pump oxygen/air to overcome the resistance of the gas diffusion layer, resulting in fast H2O2production (101.67 mg h-1cm-2) with a high oxygen utilization efficiency (44.5%–64.9%). Long-term operation stability of NADE and its high current efficiency under high current density indicate great potential to replace normal GDE for H2O2electrosynthesis and environmental remediation on an industrial scale.
A platinum standard pan-genome resource that represents the population structure of Asian rice
Authors: Zhou Yong , Chebotarov Dmytro , Kudrna Dave , Llaca Victor , Lee Seunghee , Rajasekar Shanmugam , Mohammed Nahed , Al-Bader Noor , Sobel-Sorenson Chandler , Parakkal Praveena , Arbelaez Lady Johanna , Franco Natalia , Alexandrov Nickolai , Hamilton N. Ruaraidh Sackville , Leung Hei , Mauleon Ramil , Lorieux Mathias , Zuccolo Andrea , McNally Kenneth , Zhang Jianwei , Wing Rod A. 
Published: April 2020

AbstractAs the human population grows from 7.8 billion to 10 billion over the next 30 years, breeders must do everything possible to create crops that are highly productive and nutritious, while simultaneously having less of an environmental footprint. Rice will play a critical role in meeting this demand and thus, knowledge of the full repertoire of genetic diversity that exists in germplasm banks across the globe is required. To meet this demand, we describe the generation, validation and preliminary analyses of transposable element and long-range structural variation content of 12 near-gap-free reference genome sequences (RefSeqs) from representatives of 12 of 15 subpopulations of cultivated Asian rice. When combined with 4 existing RefSeqs, that represent the 3 remaining rice subpopulations and the largest admixed population, this collection of 16 Platinum Standard RefSeqs (PSRefSeq) can be used as a template to map resequencing data to detect virtually all standing natural variation that exists in the pan-genome of cultivated Asian rice.
Combining optogenetics with sensitive FRET imaging to monitor local microtubule manipulations
Authors: Van Geel Orry , Cheung Stephanie , Gadella Theodorus W. J. 
Published: April 2020

AbstractOptogenetic methods for switching molecular states in cells are increasingly prominent tools in life sciences. Förster Resonance Energy Transfer (FRET)-based sensors can provide quantitative and sensitive readouts of altered cellular biochemistry, e.g. from optogenetics. However, most of the light-inducible domains respond to the same wavelength as is required for excitation of popular CFP/YFP-based FRET pairs, rendering the techniques incompatible with each other. In order to overcome this limitation, we red-shifted an existing CFP/YFP-based OP18 FRET sensor (COPY) by employing an sYFP2 donor and mScarlet-I acceptor. Their favorable quantum yield and brightness result in a red-shifted FRET pair with an optimized dynamic range, which could be further enhanced by an R125I point mutation that stimulates intramolecular interactions. The new sensor was named ROPY and it visualizes the interaction between the microtubule regulator stathmin/OP18 and free tubulin heterodimers. We show that through phosphorylation of the ROPY sensor, its tubulin sequestering ability can be locally regulated by photo-activatable Rac1 (PARac1), independent of the FRET readout. Together, ROPY and PARac1 provide spatiotemporal control over free tubulin levels. ROPY/PARac1-based optogenetic regulation of free tubulin levels allowed us to demonstrate that depletion of free tubulin prevents the formation of pioneer microtubules, while local upregulation of tubulin concentration allows localized microtubule extensions to support the lamellipodia.
Efficient functional screening of a cellular cDNA library to identify severe fever with thrombocytopenia syndrome virus entry factors
Authors: Shimojima Masayuki , Sugimoto Satoko , Taniguchi Satoshi , Yoshikawa Tomoki , Kurosu Takeshi , Saijo Masayuki 
Published: April 2020

AbstractThe identification of host cell factors for virus entry is useful for the molecular explanation of viral tropisms and often leads to a more profound understanding of virus-induced diseases. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus. No countermeasures against the disease exist. In this report, we show an efficient method using virus-like particles for the functional screening of a cellular cDNA library to identify SFTS virus entry factors. Two variants encoding dendritic cell-specific ICAM-3 grabbing non-integrin related (DC-SIGNR), a calcium-dependent lectin known to enhance SFTS virus infection, were successfully identified from a human liver cDNA library. We will discuss applications for yet unidentified factor(s) for SFTS virus entry and for entry factor(s) for other viruses related to SFTS virus.
Microstructured optical fiber based Fabry–Pérot interferometer as a humidity sensor utilizing chitosan polymeric matrix for breath monitoring
Authors: Shrivastav Anand M. , Gunawardena Dinusha S. , Liu Zhengyong , Tam Hwa-Yaw 
Published: April 2020

AbstractThis study reports a method for humidity sensing based on a specialty microstructured optical fiber (MOF). A suspended tri-core MOF was fabricated using the stack and draw technique. A low finesse sensing head was prepared by depositing a chitosan polymer matrix within the holes of the MOF, forming a Fabry-Pérot interferometer as a sensing platform while the chitosan film acts as the sensing material. The use of the probe for real-time breath monitoring was also successfully demonstrated. The probe possessed a maximum sensitivity of 81.05 pm/(%RH) for 90–95%RH range while the linear region of the sensor ranged from 70–95%RH. The temperature cross correlation was also experimented, and a lower influence of external temperature was observed. The probe shows an ultrafast response during human breath monitoring with a rising time and recovery time of 80 ms and 70 ms, respectively.
Linoleic acid induces metabolic stress in the intestinal microorganism Bifidobacterium breve DSM 20213
Authors: Senizza Alice , Rocchetti Gabriele , Callegari Maria Luisa , Lucini Luigi , Morelli Lorenzo 
Published: April 2020

AbstractDespite clinical and research interest in the health implications of the conjugation of linoleic acid (LA) by bifidobacteria, the detailed metabolic pathway and physiological reasons underlying the process remain unclear. This research aimed to investigate, at the molecular level, how LA affects the metabolism of Bifidobacterium breve DSM 20213 as a model for the well-known LA conjugation phenotype of this species. The mechanisms involved and the meaning of the metabolic changes caused by LA to B. breve DSM 20213 are unclear due to the lack of comprehensive information regarding the responses of B. breve DSM 20213 under different environmental conditions. Therefore, for the first time, an untargeted metabolomics-based approach was used to depict the main changes in the metabolic profiles of B. breve DSM 20213. Both supervised and unsupervised statistical methods applied to the untargeted metabolomic data allowed confirming the metabolic changes of B. breve DSM 20213 when exposed to LA. In particular, alterations to the amino-acid, carbohydrate and fatty-acid biosynthetic pathways were observed at the stationary phase of growth curve. Among others, significant up-regulation trends were detected for aromatic (such as tyrosine and tryptophan) and sulfur amino acids (i.e., methionine and cysteine). Besides confirming the conjugation of LA, metabolomics suggested a metabolic reprogramming during the whole growth curve and an imbalance in redox status following LA exposure. Such redox stress resulted in the down-accumulation of peroxide scavengers such as low-molecular-weight thiols (glutathione- and mycothiol-related compounds) and ascorbate precursors, together with the up-accumulation of oxidized (hydroxy- and epoxy-derivatives) forms of fatty acids. Consistently, growth was reduced and the levels of the oxidative stress marker malondialdehyde were higher in LA-exposed B. breve DSM 20213 than in the control.