bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-life Health as a Lifelong Precursor of Self-Related Views of Aging in Later Life
Authors: Smith Jacqui , Larkina Marina 
Published: August 2020

Abstract

Objectives
Age stereotypes and expectations about one’s own aging commence in childhood but most research focuses on predictive associations with midlife health behaviors, later-life chronic conditions, biomarkers, and longevity. Surprisingly little is known about the role of poor childhood health in these associations. This study aims to fill this gap.

Methods
Using data from the Health and Retirement Study (HRS: N = 5,773, aged 50–98), we investigated whether diagnosed chronic illness before age 16 and self-rated childhood health predict late-life self-perceptions of aging (SPA) and proportional subjective age discrepancy (PSAD). We conducted multivariate multiple regression analysis (MMRA) to determine the joint and partial effects of the two indicators of childhood health. Models included controls for childhood family financial status as well as late-life self-rated health, chronic illnesses, memory status, and demographic covariates (age, gender, race/ethnicity, marital status, socioeconomic status) in 2016.

Results
Over and above all covariates and the covariation of the two views of one’s own aging, the MMRA models revealed that the number of childhood chronic illnesses predicted SPA but not for PSAD. Self-rated childhood health predicted both SPA and PSAD in the unadjusted models, but not in the adjusted models.

Discussion
This study provides new insight into potential early-life precursors of self-evaluations of aging. In particular, childhood diagnoses of chronic illness enhance negative SPA up to 50 years later. Non-normative experiences related to poor health in childhood are lifelong foundations for socioeconomic status, health, and for self-related beliefs about age and aging.
Repetitive capture of marine fishes: implications for estimating number and mortality of releases
Authors: Runde Brendan J , Buckel Jeffrey A , Shertzer Kyle W , Bacheler Nathan M , Rudershausen Paul J , Sauls Beverly 
Published: August 2020

Abstract
In some fisheries, releases are a high percentage of total catch. Recent tagging data of marine fishes have revealed that recapture of the same individual multiple times occurs frequently. We investigated the magnitude of this phenomenon and its effect on survival using previously collected mark-recapture data of four reef-associated species. We used Cox proportional hazard regression models to examine whether survival varied with release number. For three of four species, survival was significantly higher after the second, third, and/or fourth release as compared to the first release, perhaps resulting from selection for robust individuals. Repetitive recapture implies that the estimated number of unique released fish is biased. Increased survival following later releases as compared to the initial release suggests that the number of dead discards may be similarly overestimated. We analysed the sensitivity of stock assessment results to reduced estimates of dead discards using two of our species that had recently been assessed. We found that reduced estimates of dead discards had a modest effect on assessment results but could nonetheless affect the perception of fishery status. Our findings highlight the need to revise current practices for estimating live and dead discards, either internal or external to stock assessment models.
Holomorphic Bundles Trivializable by Proper Surjective Holomorphic Map
Authors: Biswas Indranil , Dumitrescu Sorin 
Published: August 2020

AbstractGiven a compact complex manifold $M$, we investigate the holomorphic vector bundles $E$ on $M$ such that $\varphi ^* E$ is holomorphically trivial for some surjective holomorphic map $\varphi $, to $M$, from some compact complex manifold. We prove that these are exactly those holomorphic vector bundles that admit a flat holomorphic connection with finite monodromy homomorphism. A similar result is proved for holomorphic principal $G$-bundles, where $G$ is a connected reductive complex affine algebraic group.
Projected Impact of Concurrently Available Long-Acting Injectable and Daily-Oral Human Immunodeficiency Virus Preexposure Prophylaxis: A Mathematical Model
Authors: Maloney Kevin M , Le Guillou Adrien , Driggers Robert A , Sarkar Supriya , Anderson Emeli J , Malik Amyn A , Jenness Samuel M 
Published: August 2020

Abstract

Background
Long-acting injectable (LAI) human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) is reportedly efficacious, although full trial results have not been published. We used a dynamic network model of HIV transmission among men who have sex with men to assess the population impact of LAI-PrEP when available concurrently with daily-oral (DO) PrEP.

Methods
The reference model represents the current HIV epidemiology and DO-PrEP coverage (15% among those with behavioral indications for PrEP) among men who have sex with men in the southeastern United States. Primary analyses investigated varied PrEP uptake and proportion selecting LAI-PrEP. Secondary analyses evaluated uncertainty in pharmacokinetic efficacy and LAI-PrEP persistence relative to DO-PrEP.

Results
Compared with the reference scenario, if 50% chose LAI-PrEP, 4.3% (95% simulation interval, −7.3% to 14.5%) of infections would be averted over 10 years. The impact of LAI-PrEP is slightly greater than that of the DO-PrEP–only regimen, based on assumptions of higher adherence and partial protection after discontinuation. If the total PrEP initiation rate doubled, 17.1% (95% simulation interval, 6.7%–26.4%) of infections would be averted. The highest population-level impact occurred when LAI-PrEP uptake and persistence improved.

Conclusions
If LAI-PrEP replaces DO-PrEP, its availability will modestly improve the population impact. LAI-PrEP will make a more substantial impact if its availability drives higher total PrEP coverage, or if persistence is greater for LAI-PrEP.
Rapid Quantification of Plasma Creatinine Using a Novel Kinetic Enzymatic Assay
Authors: Jimenez Valencia Angela M , Kryszak Lindsay A , Goheen Joshua , Van Roy Willem , Woronoff Gabrielle , Mathieu Evelien , Gudjonsdottir Hildur , Stakenborg Tim , Clarke William A 
Published: August 2020

Abstract

Background
Enzymatic assays are among the most common diagnostic tests performed in the clinical laboratory. Enzymatic substrate analysis is most commonly measured using endpoint methods; however, modulating the reaction kinetics allows fine control of the reaction rate, which can be adjusted based on specific monitoring technologies.

Methods
We developed and optimized an enzymatic method for measurement of creatinine in plasma, using commonly paired enzymes of creatininase (Crtnnase), creatinase (Crtase), sarcosine oxidase (SOX), ascorbate oxidase (AOX), and horseradish peroxidase (HRP). The novel aspect of the assay is that it is fast and uses SOX as the limiting enzyme. The assay performance was assessed with respect to precision, accuracy, and interferences.

Results
The intrarun %CV (n = 12) was approximately 5% for each concentration tested, with biases ranging from −3 to −9%. The interrun %CV (n = 39) ranged from 5 to 8%, with biases ranging from −2 to −6%. During the accuracy assessment (n = 127), only 4 samples did not meet the minimum acceptability criteria. Minimal interference was observed, except at low creatinine concentrations with elevated creatine.

Conclusion
Our novel and versatile enzymatic assay to measure plasma creatinine using kinetic analysis with SOX as the limiting enzyme is rapid (&lt;2 mins), sensitive, and specific and demonstrates excellent concordance with the laboratory standard. We anticipate this rapid kinetic assay to be compatible with emerging technologies in the field of portable diagnostic devices, such as the usage of silicon photonics to monitor biochemical reactions.
Nurses Can Resuscitate
Authors: Cooper Cheryl , Cochran Amalia , Coffey Rebecca 
Published: August 2020

Abstract
Fluid resuscitation in the first 48 hours postburn is crucial in the management of burn shock. The primary purpose of this study was to evaluate nurses’ adherence to a nurse-driven fluid resuscitation protocol at one adult burn center. Their secondary goal was to establish that the use of a nursing-driven protocol did not result in over resuscitation. Following implementation of a nurse-driven burn resuscitation protocol, a 48-hour data resuscitation data collection tool was developed by the burn physicians and nurses. All resuscitations were reviewed in real-time and in burn leadership meeting to identify opportunities for improvement. Follow-up with nursing staff was done in real time by the clinical nurse specialist following each burn resuscitation. Twenty-two patients requiring formal fluid resuscitation were included in the review. Patients had a median age of 36.5(IQR: 38.74) years and were predominantly male. They found that in the first 24 hours that patients received 3.47 ml/kg/hr and then in the next 24 hours they received an average of 2.68 ml/kg/hr. All 22 patients’ resuscitation was initiated using the Parkland formula in the emergency department, and nurses were successful in consistently adjusting fluid infusions consistent with the protocol. Using a multidisciplinary approach and preparatory and real-time education processes, burn nurses can successfully guide burn resuscitation. Providing education and follow-up in real time can improve the process.
The Impact of Mass Spectrometry on Patients’ Medical and Nonmedical Lives
Authors: Wu Alan H B 
Published: August 2020

Abstract

Objective
The various forms of mass spectrometry (MS) instrumentation have had a major impact on testing for analytes performed with clinical and forensic laboratories over the past decade. Improvements in MS instrumentation have led to the use of MS in many areas.

Methods
To highlight the value of MS testing, short reports are presented that are relevant to the following fields: pain management, transplant medicine, clinical toxicology, designer drug testing, genetic metabolic disorders, nutrition, dietary exposure to heavy metals, herbals and supplements, forensic pathology, pharmacogenomics, homeland security, performance enhancing drugs and peptides, clinical microbiology, physician licensing, and environmental exposures. These reports are based on real patients. The “stories” have been altered to comply with privacy regulations.

Results
Analysis of MS provides objective results that have an impact on many areas of medicine and society as a whole. Accurate analysis has an impact on guidance for medical practices.

Conclusion
The value of MS testing will continue to grow in the years to come.
STRIDES: Spectroscopic and photometric characterization of the environment and effects of mass along the line of sight to the gravitational lenses DES J0408–5354 and WGD 2038–4008
Authors: Buckley-Geer E J , Lin H , Rusu C E , Poh J , Palmese A , Agnello A , Christensen L , Frieman J , Shajib A J , Treu T , Collett T , Birrer S , Anguita T , Fassnacht C D , Meylan G , Mukherjee S , Wong K C , Aguena M , Allam S , Avila S , Bertin E , Bhargava S , Brooks D , Carnero Rosell A , Carrasco Kind M , Carretero J , Castander F J , Costanzi M , da Costa L N , De Vicente J , Desai S , Diehl H T , Doel P , Eifler T F , Everett S , Flaugher B , Fosalba P , García-Bellido J , Gaztanaga E , Gruen D , Gruendl R A , Gschwend J , Gutierrez G , Hinton S R , Honscheid K , James D J , Kuehn K , Kuropatkin N , Maia M A G , Marshall J L , Melchior P , Menanteau F , Miquel R , Ogando R L C , Paz-Chinchón F , Plazas A A , Sanchez E , Scarpine V , Schubnell M , Serrano S , Sevilla-Noarbe I , Smith M , Soares-Santos M , Suchyta E , Swanson M E C , Tarle G , Tucker D L , Varga T N ,   (The DES Collaboration)
Published: August 2020

ABSTRACT
In time-delay cosmography, three of the key ingredients are (1) determining the velocity dispersion of the lensing galaxy, (2) identifying galaxies and groups along the line of sight with sufficient proximity and mass to be included in the mass model, and (3) estimating the external convergence κext from less massive structures that are not included in the mass model. We present results on all three of these ingredients for two time-delay lensed quad quasar systems, DES J0408–5354 and WGD 2038–4008 . We use the Gemini, Magellan, and VLT telescopes to obtain spectra to both measure the stellar velocity dispersions of the main lensing galaxies and to identify the line-of-sight galaxies in these systems. Next, we identify 10 groups in DES J0408–5354 and two groups in WGD 2038–4008 using a group-finding algorithm. We then identify the most significant galaxy and galaxy-group perturbers using the ‘flexion shift’ criterion. We determine the probability distribution function of the external convergence κext for both of these systems based on our spectroscopy and on the DES-only multiband wide-field observations. Using weighted galaxy counts, calibrated based on the Millennium Simulation, we find that DES J0408–5354 is located in a significantly underdense environment, leading to a tight (width $\sim 3{{\ \rm per\ cent}}$), negative-value κext distribution. On the other hand, WGD 2038–4008 is located in an environment of close to unit density, and its low source redshift results in a much tighter κext of $\sim 1{{\ \rm per\ cent}}$, as long as no external shear constraints are imposed.
A common explanation of the Hubble tension and anomalous cold spots in the CMB
Authors: Kovács A , Beck R , Szapudi I , Csabai I , Rácz G , Dobos L 
Published: August 2020

ABSTRACT
The standard cosmological paradigm narrates a reassuring story of a universe currently dominated by an enigmatic dark energy component. Disquietingly, its universal explaining power has recently been challenged by, above all, the ∼4σ tension in the values of the Hubble constant. Another, less studied anomaly is the repeated observation of integrated Sachs–Wolfe (ISW) imprints ∼5× stronger than expected in the Lambda cold dark matter (ΛCDM) model from $R_{\rm v}\gtrsim 100\,\rm {\mathit{ h}^{-1}Mpc }$ superstructures. Here, we show that the inhomogeneous AvERA (Average Expansion Rate Approximation) model of emerging curvature is capable of telling a plausible albeit radically different story that explains both observational anomalies without dark energy. We demonstrate that while stacked imprints of $R_{\rm v}\gtrsim 100\,\rm {\mathit{ h}^{-1}Mpc }$ supervoids in cosmic microwave background (CMB) temperature maps can discriminate between the AvERA and ΛCDM models, their characteristic differences may remain hidden using alternative void definitions and stacking methodologies. Testing the extremes, we then also show that the CMB Cold Spot can plausibly be explained in the AvERA model as an ISW imprint. The coldest spot in the AvERA map is aligned with multiple low-z supervoids with $R_{\rm v}\gtrsim 100\,\rm {\mathit{ h}^{-1}Mpc }$ and central underdensity δ0 ≈ −0.3, resembling the observed large-scale galaxy density field in the Cold Spot area. We hence conclude that the anomalous imprint of supervoids may well be the canary in the coal mine, and existing observational evidence for dark energy should be reinterpreted to further test alternative models.
The gas production of 14 species from comet 67P/Churyumov–Gerasimenko based on DFMS/COPS data from 2014 to 2016
Authors: Läuter Matthias , Kramer Tobias , Rubin Martin , Altwegg Kathrin 
Published: August 2020

ABSTRACT
The coma of comet 67P/Churyumov–Gerasimenko has been probed by the Rosetta spacecraft and shows a variety of different molecules. The ROSINA COmet Pressure Sensor and the Double Focusing Mass Spectrometer provide in situ densities for many volatile compounds including the 14 gas species H2O, CO2, CO, H2S, O2, C2H6, CH3OH, H2CO, CH4, NH3, HCN, C2H5OH, OCS, and CS2. We fit the observed densities during the entire comet mission between 2014 August and 2016 September to an inverse coma model. We retrieve surface emissions on a cometary shape with 3996 triangular elements for 50 separated time intervals. For each gas, we derive systematic error bounds and report the temporal evolution of the production, peak production, and the time-integrated total production. We discuss the production for the two lobes of the nucleus and for the Northern and Southern hemispheres. Moreover, we provide a comparison of the gas production with the seasonal illumination.
Constraining the scatter in the galaxy–halo connection at Milky Way masses
Authors: Cao Jun-zhi , Tinker Jeremy L , Mao Yao-Yuan , Wechsler Risa H 
Published: August 2020

ABSTRACT
We develop and implement two new methods for constraining the scatter in the relationship between galaxies and dark matter haloes. These new techniques are sensitive to the scatter at low halo masses, making them complementary to previous constraints that are dependent on clustering amplitudes or rich galaxy groups, both of which are only sensitive to more massive haloes. In both of our methods, we use a galaxy group finder to locate central galaxies in the Sloan Digital Sky Survey main galaxy sample. Our first technique uses the small-scale cross-correlation of central galaxies with all lower mass galaxies. This quantity is sensitive to the satellite fraction of low-mass galaxies, which is in turn driven by the scatter between haloes and galaxies. The second technique uses the kurtosis of the distribution of line-of-sight velocities between central galaxies and neighbouring galaxies. This quantity is sensitive to the distribution of halo masses that contain the central galaxies at fixed stellar mass. Theoretical models are constructed using peak halo circular velocity, Vpeak, as our property to connect galaxies to haloes, and all comparisons between theory and observation are made after first passing the model through the group-finding algorithm. We parametrize scatter as a lognormal distribution in M* at fixed Vpeak, σ[M*|Vpeak]. The cross-correlation technique yields a constraint of σ[M*|Vpeak] = 0.27 ± 0.05 dex at a mean Vpeak of 168 km s−1, corresponding to a scatter in log M* at fixed Mh of σ[M*|Mh] = 0.38 ± 0.06 dex at $M_\text{h}=10^{11.8}\, \text{M}_\odot$. The kurtosis technique yields σ[M*|Vpeak] = 0.30 ± 0.03 at Vpeak = 209 km s−1, corresponding to σ[M*|Mh] = 0.34 ± 0.04 at $M_\text{h}=10^{12.2}\, \text{M}_\odot$. The values of σ[M*|Mh] are significantly larger than the constraints at higher masses, in agreement with the results of hydrodynamic simulations. This increase is only partly due to the scatter between Vpeak and Mh, and it represents an increase of nearly a factor of 2 relative to the values inferred from clustering and group studies at high masses.
Spectroscopic study of magnesium dinitrogen and sodium dinitrogen cation
Authors: Cheng Qianyi , Washington Maura C , Burns Joseph E , Fortenberry Ryan C , DeYonker Nathan J 
Published: August 2020

ABSTRACT
Despite its likely importance in astrochemistry, pure rotational spectra are not observable for gas-phase N2 since this molecule has no permanent dipole moment. Complexation of monomeric N2 with a cationic metal (MN2+) may be kinetically and thermodynamically favourable, and the detection of such MN2+ molecules could be useful tracers of N2 in order to probe its abundance and kinetics. Highly accurate quartic force field methods have been applied here to compute rotational and vibrational spectroscopic properties of the NaN2+ and MgN2+ molecules via a coupled cluster-based composite approach with additional corrections for post-CCSD(T) electron correlation and relativistic effects. The relative energies of various isomers have also been computed and show that both NaN2+ and MgN2+ have linear ground electronic states. At the highest level of theory, rotational constants (B0) of 4086.9 and 4106.0 MHz are predicted for NaN2+ and MgN2+, respectively, with dipole moments of 6.92 and 4.34 D, respectively, making them rotationally observable even at low concentrations. Post-CCSD(T) electron correlation corrections lower the N–N stretching frequency while relativistic corrections have a much smaller effect putting the fundamental frequencies at 2333.7 and 2313.6 cm−1, respective of NaN2+ and MgN2+ slightly above that in N2H+. Additive corrections do not significantly change the other two vibrational modes. An anharmonic, zero-point corrected N2 dissociation energy of 7.3 and 7.0 kcal mol−1 is, respectively, reported for NaN2+ and MgN2+ suggesting possible formation of these molecules in protoplanetary discs or planetary nebulae that are metal- and nitrogen-rich.
Identification of a Unique Type of Isoflavone O-Methyltransferase, GmIOMT1, Based on Multi-Omics Analysis of Soybean under Biotic Stress
Authors: Uchida Kai , Sawada Yuji , Ochiai Koji , Sato Muneo , Inaba Jun , Hirai Masami Yokota 
Published: August 2020

Abstract
Isoflavonoids are commonly found in leguminous plants. Glycitein is one of the isoflavones produced by soybean. The genes encoding the enzymes in the isoflavone biosynthetic pathway have mostly been identified and characterized. However, the gene(s) for isoflavone O-methyltransferase (IOMT), which catalyzes the last step of glycitein biosynthesis, has not yet been identified. In this study, we conducted multi-omics analyses of fungal-inoculated soybean and indicated that glycitein biosynthesis was induced in response to biotic stress. Moreover, we identified a unique type of IOMT, which participates in glycitein biosynthesis. Soybean seedlings were inoculated with Aspergillus oryzae or Rhizopus oligosporus and sampled daily for 8 d. Multi-omics analyses were conducted using liquid chromatography–tandem mass spectrometry and RNA sequencing. Metabolome analysis revealed that glycitein derivatives increased following fungal inoculation. Transcriptome co-expression analysis identified two candidate IOMTs that were co-expressed with the gene encoding flavonoid 6-hydroxylase (F6H), the key enzyme in glycitein biosynthesis. The enzymatic assay of the two IOMTs using respective recombinant proteins showed that one IOMT, named as GmIOMT1, produced glycitein. Unlike other IOMTs, GmIOMT1 belongs to the cation-dependent OMT family and exhibited the highest activity with Zn2+ among cations tested. Moreover, we demonstrated that GmIOMT1 overexpression increased the levels of glycitein derivatives in soybean hairy roots when F6H was co-expressed. These results strongly suggest that GmIOMT1 participates in inducing glycitein biosynthesis in response to biotic stress.
A Sicilian–Cretan biogeographical disjunction in the land snail genusCornu(Gastropoda: Helicidae)
Authors: Hausdorf Bernhard , Bamberger Sonja , Walther Frank 
Published: August 2020

AbstractWe report an unusual biogeographical disjunction between the western and the eastern Mediterranean region. Cornu (Gastropoda: Helicidae) is a western Mediterranean land snail genus. It includes Cornu (Cornu) aspersum, which originated in north-western Africa and was distributed by humans for food or accidentally, first throughout the Mediterranean region and, subsequently, to all continents except Antarctica. It also includes three species belonging to the subgenus Erctella, which are all endemic to Sicily. We discovered a new species of Cornu on the Greek island of Crete. The morphological and molecular genetic analyses showed that the species from Crete is a disjunct representative of the subgenus Erctella. We hypothesize that the disjunction originated by a long-distance dispersal event of the ancestors of the Cretan species from Sicily by birds or by sea currents, perhaps facilitated by a tsunami or a similar event. The Cretan lineage separated from the Sicilian species in the Late Miocene or Early Pliocene. This divergence time is compatible with the hypothesis that the ancestor of Cornu cretense sp. nov. was washed from Sicily to Crete by the Zanclean flood that refilled the Mediterranean basin after it had dried up during the Messinian salinity crisis.