bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating New Zealand’s harvested wood products carbon stocks and stock changes
Authors: Wakelin Stephen J. , Searles Nigel , Lawrence Daniel , Paul Thomas S. H. 
Published: May 2020

Abstract
Background
Reducing net greenhouse gas emissions through conserving existing forest carbon stocks and encouraging additional uptake of carbon in existing and new forests have become important climate change mitigation tools. The contribution of harvested wood products (HWPs) to increasing carbon uptake has been recognised and approaches to quantifying this pool developed. In New Zealand, harvesting has more than doubled since 1990 while log exports have increased by a factor of 11 due to past afforestation and comparatively little expansion in domestic processing. This paper documents New Zealand’s application of the IPCC approaches for reporting contributions of the HWP pool to net emissions, in order to meet international greenhouse gas inventory reporting requirements. We examine the implications of the different approaches and assumptions used in calculating the HWP contribution and highlight model limitations.

Results
Choice of system boundary has a large impact for a country with a small domestic market and significant HWP exports. Under the Production approach used for New Zealand’s greenhouse gas inventory reporting, stock changes in planted forests and in HWPs both rank highly as key categories. The contribution from HWPs is even greater under the Atmospheric Flow approach, because emissions from exported HWPs are not included. Conversely the Stock Change approach minimises the contribution of HWPs because the domestic market is small. The use of country-specific data to backfill the time series from 1900 to 1960 has little impact but using country-specific parameters in place of IPCC defaults results in a smaller HWP sink for New Zealand. This is because of the dominance of plantation forestry based on a softwood mainly used in relatively short-lived products.

Conclusions
The NZ HWP Model currently meets international inventory reporting requirements. Further disaggregation of the semi-finished HWP end uses both within New Zealand and in export markets is required to improve accuracy. Product end-uses and lifespans need to be continually assessed to capture changes. More extensive analyses that include the benefits of avoided emissions through product substitution and life cycle emissions from the forestry sector are required to fully assess the contribution of forests and forest products to climate change mitigation and a low emissions future.
Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China
Authors: Wang Zhiling , Liu Ting , Wang Yunjian , Gu Ying , Wang Hui , Liu Jingkang , Cui Baoxia , Yang Xingsheng 
Published: May 2020

Abstract
Background
To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology.

Methods
In this cross-sectional study, the result of the hr-HPV test and biopsy of colposcopy of women with normal cytology from January 2012 to January 2019 were analyzed. The detection rate of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer were calculated among different hr-HPV genotypes, viral load group, and age groups.

Results
Five thousand eight hundred eighty women were enrolled in this study. Overall, 59.97% had normal histological results, 19.32% had HSIL, and 1.07% had cervical cancer. The detection rate of HSIL or worse (HSIL+) in women with single HPV16(34.00%), HPV31(27.50%), HPV33(25.58%), and HPV52(20.88%) infection were higher significantly than single HPV18 (15.59%) infection, respectively. The HSIL+ detection rate between HPV16 single infection and multiple infections (excluding HPV18) was no significant difference (34% vs 35.47%, P = 0.638), contrary to HPV18(12.59% vs 21.67%, P = 0.022). In women without HPV16/18 infections, HSIL+ detection rates for single, double, and triple or more hr-HPV infections were 12.28, 20.31, and 37.50%, the risk of detection of HSIL+ significantly increasing. With the hr-HPV DNA load increases, the risk of detection of HSIL+ (χ2 = 91.01, P < 0.0001) and invasive cervical cancer (χ2 = 5.757, P = 0.016) increase. In age < 30, 31–40, 41–50, 51–60, > 60 group, HSIL+ detection rate were 24.80%、22.10%、19.59%、14.29, and 12.61%, respectively.

Conclusion
Women who have normal cytology with HPV 16/18/31/33/52/58 infections, multiple HPV infections and high viral load, have a higher detection rate of HSIL+.
Neuroradiology training in EU: international survey of 31 countries within UEMS frame
Authors: Pizzini Francesca B. , Sasiadek Marek , Tanzi Francesco , Ricci Paolo 
Published: May 2020

Abstract
Objective
To assess the current framework of interventional and diagnostic neuroradiology in Europe

Methods
The UEMS (European Union of Medical Specialists) Section of Radiology and the subspecialty UEMS Division of Neuroradiology collected by e-mail a survey on the situation of diagnostic and Interventional Neuroradiology’ training and practice in Europe. The questionnaire was sent to the national delegates from 31 UEMS member countries, belonging to the European Union, the European Economic Area and the Council of Europe. In case of uncertain or discordant replies, the survey envisaged the involvement of neuroradiology scientific societies’ experts for providing a decisive answer.

Results
A formal post-residency training in diagnostic and interventional neuroradiology is provided respectively by 12/31 and 20/31 of the European countries. Currently, for becoming neuroradiologist in a country without fellowship program, a radiologist should (1) get subspecialty credits, (2) follow training inside national or international neuroradiology departments, or (3) perform the main reporting activity in neuroradiology.
In nearly 2/3 of the States included in the survey, the neurointerventional procedures are provided by radiologists (22/31) and in the most frequent scenario a specific training in neurovascular is required to all radiologist or non-radiologist candidates (18/31).

Conclusions
The European framework of neuroradiology’s training and practice that emerged through this survey is fragmented, but there is an increasing attention by European scientific societies and institutions to create a common path of training and practice that can guarantee high educational and patient care standards.
Subducted oceanic crust as the origin of seismically slow lower-mantle structures
Authors: Jones Timothy D. , Maguire Ross R. , van Keken Peter E. , Ritsema Jeroen , Koelemeijer Paula 
Published: May 2020

AbstractMantle tomography reveals the existence of two large low-shear-velocity provinces (LLSVPs) at the base of the mantle. We examine here the hypothesis that they are piles of oceanic crust that have steadily accumulated and warmed over billions of years. We use existing global geodynamic models in which dense oceanic crust forms at divergent plate boundaries and subducts at convergent ones. The model suite covers the predicted density range for oceanic crust over lower mantle conditions. To meaningfully compare our geodynamic models to tomographic structures, we convert them into models of seismic wavespeed and explicitly account for the limited resolving power of tomography. Our results demonstrate that long-term recycling of dense oceanic crust naturally leads to the formation of thermochemical piles with seismic characteristics similar to the LLSVPs. The extent to which oceanic crust contributes to the LLSVPs depends upon its density in the lower mantle for which accurate data is lacking. We find that the LLSVPs are not composed solely of oceanic crust. Rather, they are basalt rich at their base (bottom 100–200 km) and grade into peridotite toward their sides and top with the strength of their seismic signature arising from the dominant role of temperature. We conclude that recycling of oceanic crust, if sufficiently dense, has a strong influence on the thermal and chemical evolution of Earth’s mantle.
Sensitivity study for ICON tidal analysis
Authors: Cullens Chihoko Y. , Immel Thomas J. , Triplett Colin C. , Wu Yen-Jung , England Scott L. , Forbes Jeffrey M. , Liu Guiping 
Published: May 2020

AbstractRetrieval of the properties of the middle and upper atmosphere can be performed using several different interferometric and photometric methods. The emission-shape and Doppler shift of both atomic and molecular emissions can be observed from the ground and space to provide temperature and bulk velocity. These instantaneous measurements can be combined over successive times/locations along an orbit track, or successive universal/local times from a ground station to quantify the motion and temperature of the atmosphere needed to identify atmospheric tides. In this report, we explore how different combinations of space-based wind and temperature measurements affect the retrieval of atmospheric tides, a ubiquitous property of planetary atmospheres. We explore several scenarios informed by the use of a tidally forced atmospheric circulation model, an empirically based emissions reference, and a low-earth orbit satellite observation geometry based on the ICON mission design. This capability provides a necessary tool for design of an optimal mission concept for retrieval of atmospheric tides from ICON remote-sensing observations. Here it is used to investigate scenarios of limited data availability and the effects of rapid changes in the total wave spectrum on the retrieval of the correct tidal spectrum. An approach such as that described here could be used in the design of future missions, such as the NASA DYNAMIC mission (National Research Council, Solar and space physics: a science for a technological society, 2013).
Toxicological evaluations of combined administration of ethanolic stem bark extract of Enantia chlorantha and lisinopril in experimental type 2 diabetes
Authors: Ajani Emmanuel Oladipo , Ibrahim Latifat Bolanle 
Published: May 2020

Abstract
Background
Enantia chlorantha is a local medicinal plant commonly use in Nigeria for the treatment of diabetes but without support of scientific data. Large percentage of people suffering from diabetes who uses the plant as antidiabetic agent also combine its administration with standard antihypertensive drugs.

Aim
In the present study, we have investigated the possible toxicological effects of combined administration of E. chlorantha bark extract and lisinopril in diabetic model of experimental rats.

Methods
E. chlorantha stem bark was extracted by cold maceration of the pulverised stem bark in 70% ethanol. The acute toxicity effect of the plant was then evaluated in rats following oral administration of single dose of the extract. Diabetes was induced by intraperitoneal administration of 40 mg/kg streptozotocin into fructose fed rat. Diabetic rats were then randomly assigned into 6 groups of 7 rats each. One group was kept as the diabetic model while separate treatments were administered to the other six groups. Seven non diabetic rats were kept as the control group and administered normal saline.

Results
The LD50 of E. chlorantha stem bark was above 5000 mg/kg. Combined administration of lisinopril and E. chlorantha showed synergistic effects in the restoration of renal biomarkers (serum creatinine, urea, Na+ and K+), cardiac function biomarkers (CK-MB and LDH) and hematological parameters (RBC, WBC, HGB and PCV), while antagonistic effects were however observed with some of the liver biomarkers (AST, ALT, ALP, GGT, total protein and total bilirubin). Rats co-administered lisinopril and E. chlorantha also showed fatty liver with cholestasis.

Conclusion
The study concluded that diabetes is associated with kidney and cardiac dysfunction. Combined administration of lisinopril and E. chlorantha though may not aggravate these dysfunctions however, it may antagonize the efficacy of the plant in ameliorating liver dysfunction in diabetics.
Portfolio optimization of credit risky bonds: a semi-Markov process approach
Authors: Pasricha Puneet , Selvamuthu Dharmaraja , D’Amico Guglielmo , Manca Raimondo 
Published: May 2020

AbstractThis article presents a semi-Markov process based approach to optimally select a portfolio consisting of credit risky bonds. The criteria to optimize the credit portfolio is based onl∞-norm risk measure and the proposed optimization model is formulated as a linear programming problem. The input parameters to the optimization model are rate of returns of bonds which are obtained using credit ratings assuming that credit ratings of bonds follow a semi-Markov process. Modeling credit ratings by semi-Markov processes has several advantages over Markov chain models, i.e., it addresses the ageing effect present in the credit rating dynamics. The transition probability matrices generated by semi-Markov process and initial credit ratings are used to generate rate of returns of bonds. The empirical performance of the proposed model is analyzed using the real data. Further, comparison of the proposed approach with the Markov chain approach is performed by obtaining the efficient frontiers for the two models.
Predictors of CD4 count changes over time among children who initiated highly active antiretroviral therapy in Ethiopia
Authors: Birhan Tilahun Yemanu , Gezie Lemma Derseh , Teshome Destaw Fetene , Sisay Malede Mequanent 
Published: May 2020

Abstract
Introduction
Human immunodeficiency virus (HIV) infection results in a gradual depletion of immune function, particularly CD4 cells. The CD4 assessment plays a significant role in assessing treatment responses and clinical decision-making for patients on combination antiretroviral therapy (ART) in resource-limited settings. However, new data on CD4 count changes are scarce; the volatility of CD4 counts after initiation of ART over time remains largely uncharacterized. This study aimed to identify the predictors of CD4 changes over time among HIV-infected children who began ART in Amhara, Ethiopia.

Methods
A retrospective follow-up study was performed. A total of 983 HIV-infected children who initiated ART in government hospitals in the Amhara region between 2010 and 2016 were included using a simple random sampling technique. Data were extracted using a structured checklist. An exploratory data analysis was carried out to explain individual and average profile plots. The linear mixed model was used to identify the CD4 change count predictors over time. Variables with p value < 0.05 were considered statistically significant in a multivariable linear mixed regression analysis.

Results
The mean CD4 count of the participants was 465.1 cells/mm3 with an average CD4 count increase of 30.06 cells/mm3 over 6 months from baseline CD4 count and ART initiation. Childhood age (β = − 0.015; 95% Cl − 0.021, − 0.009), opportunistic infection at ART initiation (β = − 0.044, 95% CI − 0.085, − 0.004), hemoglobin level (β = 0.013; 95% CI 0.004, 0.022), and baseline WHO clinical stage II (β = − 0.046, 95% CI − 0.091, − 0.0003) were significant predictors of CD4 changes over time.

Conclusions
The average CD4 count increase was sufficient in HIV patients who began combined antiretroviral therapy over time. The younger age of the infant, the higher baseline level of hemoglobin, the baseline WHO clinical stage II, and opportunistic infections led to changes in CD4 counts. As a result, timely diagnosis and treatment of opportunistic infections will reduce the risk of opportunistic infections.
Membrane lipid raft organization during cotton fiber development
Authors: XU Fan , SUO Xiaodong , LI Fang , BAO Chaoya , HE Shengyang , HUANG Li , LUO Ming 
Published: May 2020

Abstract
Background
Cotton fiber is a single-celled seed trichome that originates from the ovule epidermis. It is an excellent model for studying cell elongation. Along with the elongation of cotton fiber cell, the plasma membrane is also extremely expanded. Despite progress in understanding cotton fiber cell elongation, knowledge regarding the relationship of plasma membrane in cotton fiber cell development remains elusive.

Methods
The plasma membrane of cotton fiber cells was marked with a low toxic fluorescent dye, di-4-ANEPPDHQ, at different stages of development. Fluorescence images were obtained using a confocal laser scanning microscopy. Subsequently, we investigated the relationship between lipid raft activity and cotton fiber development by calculating generalized polarization (GP values) and dual-channel ratio imaging.

Results
We demonstrated that the optimum dyeing conditions were treatment with 3 μmol·L− 1 di-4-ANEPPDHQ for 5 min at room temperature, and the optimal fluorescence images were obtained with 488 nm excitation and 500–580 nm and 620–720 nm dual channel emission. First, we examined lipid raft organization in the course of fiber development. The GP values were high in the fiber elongation stage (5–10 DPA, days past anthesis) and relatively low in the initial (0 DPA), secondary cell wall synthesis (20 DPA), and stable synthesis (30 DPA) stages. The GP value peaked in the 10 DPA fiber, and the value in 30 DPA fiber was the lowest. Furthermore, we examined the differences in lipid raft activity in fiber cells between the short fiber cotton mutant, Li-1, and its wild-type. The GP values of the Li-1 mutant fiber were lower than those of the wild type fiber at the elongation stage, and the GP values of 10 DPA fibers were lower than those of 5 DPA fibers in the Li-1 mutant.

Conclusions
We established a system for examining membrane lipid raft activity in cotton fiber cells. We verified that lipid raft activity exhibited a low-high-low change regularity during the development of cotton fiber cell, and the pattern was disrupted in the short lint fiber Li-1 mutant, suggesting that membrane lipid order and lipid raft activity are closely linked to fiber cell development.
Progress and mechanism of breaking glycoconjugates by glycosidases in skin for promoting unhairing and fiber opening-up in leather manufacture. A review
Authors: Luo Fengxiang , Zhong Xiang , Gao Mengchu , Peng Biyu , Long Zhongzhen 
Published: May 2020

AbstractThe glycoconjugates, herein glyco-proteins, existing in animal skins are closely related to the effectiveness of unhairing and fiber opening-up. Glycosidases have been used in leather making processes to reduce pollutants and improve leather quality. But the selection of glycosidases is still blind because the related mechanisms are not well understood yet. Hence, the animal skin structures and glycoconjugates components, the advances in the methods and mechanisms of removing glycoconjugates related to unhairing and fiber opening-up in leather manufacture, the kinds, compositions, structures and functions of typical glycoconjugates in skin are summarized. Then the approaches to destroy them, possible glycosidases suitable for leather making and their acting sites are analyzed based on the recognition of glycoconjugates in skin and the specificities of glycosidases toward substrates. It is expected to provide useful information for the optimization of glycosidases and the development of new enzymes and the cleaner technologies of unhairing and opening up fiber bundles assisted by glycosidases.Graphical abstract
Can social isolation caused by physical distance in people with psychosis be overcome through a Phone Pal?
Authors: Pinto da Costa Mariana 
Published: May 2020

Abstract
The current pandemic has forced many people into self-isolation and to practice social distancing. When people are physically isolated and distant from each other, technology may play a fundamental role by enabling social connection and reducing feelings of loneliness caused by this prolonged social isolation. In response to the COVID-19 pandemic, many mental health services worldwide have had to shift their routine face-to-face outpatient appointments to remote telepsychiatry encounters. The increased pressure on mental health services highlights the importance of community-led health-promotion interventions, which can contribute to preventing mental illness or their relapses, and to reduce the burden on health services. Patients with psychosis are particularly socially isolated, have sedentary lifestyles, and commonly face stigma and discrimination from the general population. At the same time, patients with psychosis value technology, are interested in, use and own smart-phones to digitally connect, and are satisfied with their use. Thus, among psychosocial interventions, a helpful resource may be “Phone Pal,” a complex intervention which facilitates remote communication between volunteers and socially isolated patients with psychosis through different smart-phone tools. While “Phone Pal” has been originally developed for people with psychosis, it may also be useful to the wider population, helping to overcome the social isolation caused by physical distancing, particularly in these times of widespread isolation. “Phone Pal” may be a potential public health resource for society, providing important support to those that may need it the most, and possibly benefit most from it.
Branching morphogenesis
Authors: Goodwin Katharine , Nelson Celeste M. 
Published: May 2020

ABSTRACT
Over the past 5 years, several studies have begun to uncover the links between the classical signal transduction pathways and the physical mechanisms that are used to sculpt branched tissues. These advances have been made, in part, thanks to innovations in live imaging and reporter animals. With modern research tools, our conceptual models of branching morphogenesis are rapidly evolving, and the differences in branching mechanisms between each organ are becoming increasingly apparent. Here, we highlight four branched epithelia that develop at different spatial scales, within different surrounding tissues and via divergent physical mechanisms. Each of these organs has evolved to employ unique branching strategies to achieve a specialized final architecture.
Autophagy and endocytosis – interconnections and interdependencies
Authors: Birgisdottir Åsa B. , Johansen Terje 
Published: May 2020

ABSTRACT
Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded. In addition, the two pathways intersect at different stages during vesicle formation, fusion and trafficking, and share parts of the molecular machinery. Accumulating evidence shows that autophagy is dependent upon endocytosis and vice versa. The emerging joint network of autophagy and endocytosis is of vital importance for cellular metabolism and signaling, and thus also highly relevant in disease settings. In this Review, we will discuss examples of how the autophagy machinery impacts on endocytosis and cell signaling, and highlight how endocytosis regulates the different steps in autophagy in mammalian cells. Finally, we will focus on the interplay of these pathways in the quality control of their common endpoint, the lysosome.