bluuebunny/crossref_metadata_2025_split huggingface dataset:
Science and Engineering Practices: a Comparative Analysis of Indonesian, Thai and Vietnamese Science Curricula
Authors: Prasoplarb Tharuesean , Faikhamta Chatree , Khan Samia , Lertdechapat Kornkanok , Van Bien Nguyen , El Islami R. Ahmad Zaky , Xue Song , Khwaengmek Vipavadee , Hennessey Alison 
Published: December 2024

Abstract
Southeast Asian countries are embracing updated integrated curricula, such as STEM, which are impacted by socio-scientific, political, and economic reasons related to global educational reform. This study compares science curricula regarding science and engineering practices (SEP s) in Indonesian, Thai, and Vietnamese science curricula. The SEP s in the curricular learning outcomes were examined using qualitative content analysis. According to the analysis, the learning outcomes of the three Southeast Asian countries were more aligned with science than engineering. Students most often practiced ‘constructing scientific explanations,’ while the least common was ‘asking questions and defining problems’ across countries. Compared to Indonesia and Vietnam, the Thai curriculum typically included ‘developing a model’, a key science and engineering practice. The findings suggest that curriculum design may reconsider integration, curricular coherence, and learning goals for modelling, asking questions, and engineering to increase engagement with diverse activities.
The metabolic hypothesis for restrictive eating behaviors: A computational and evolutionary approach
Authors: Tarchi Livio , Merola Giuseppe Pierpaolo , Maiolini Gaia , D’Areglia Eleonora , Ricca Valdo , Castellini Giovanni 
Published: December 2024

Background Restrictive eating behaviors, widespread in humans and animals, are often conceptualized as maladaptive, but may serve adaptive purposes under specific circumstances. Aim To investigate the adaptive potential of restrictive eating behaviors. Methods Computational models explored the relationship between food availability, basal metabolic rate, and restrictive eating behaviors. The evolutionary conservation of genes associated with both basal metabolic rate and restrictive eating behaviors was evaluated. Results The propensity to engage in restrictive eating behaviors protected against negative energy balances at times of food volatility, implying ecological fitness potential. A high degree of conservation across species was observed in retrieved genes, implying selective evolutionary constraints. Conclusion Restrictive eating behaviors may represent a maladaptive outcome of evolutionary constraints on protective metabolic mechanisms. The higher prevalence of restrictive eating in women could stem from a greater reliance on protective strategies, highlighting the need for further exploration of sex-specific genetic and environmental interactions.
Quantitative analysis of deep learning reconstruction in CT angiography: Enhancing CNR and reducing dose
Authors: Lee Chang-Lae 
Published: December 2024

Background Computed tomography angiography (CTA) provides significant information on image quality in vascular imaging, thus offering high-resolution images despite having the disadvantages of increased radiation doses and contrast agent-related side effects. The deep-learning image reconstruction strategies were used to quantitatively evaluate the enhanced contrast-to-noise ratio (CNR) and the dose reduction effect of subtracted images. Objective This study aimed to elucidate a comprehensive understanding of the quantitative image quality features of the conventional filtered back projection (FBP) and the advanced intelligent clear-IQ engine (AiCE), a deep learning reconstruction technique. The comparison was made in subtracted images with variable concentrations of contrast agents at variable tube currents and voltages, enhancing our knowledge of these two techniques. Methods Data were obtained using a state-of-the-art 320-detector CT scanner. Image reconstruction was performed using FBP and AiCE with various intensities. The image quality evaluation was based on eight iodine concentrations in the phantom setup. The efficiency of AiCE relative to FBP was assessed by computing parameters including the root mean square error (RMSE), dose-dependent CNR, and potential dose reduction. Results The results showed that elevated concentrations of iodine and increased tube currents improved AiCE performance regarding CNR enhancement compared to FBP. AiCE also demonstrated a potential dose reduction ranging from 13.7 to 81.9% compared to FBP, suggesting a significant reduction in radiation exposure while maintaining image quality. Conclusions The employment of deep learning image reconstruction with AiCE presented a significant improvement in CNR and potential dose reduction in CT angiography. This study highlights the potential of AiCE to improve vascular image quality and decrease radiation exposure risk, thereby improving diagnostic precision and patient care in vascular imaging practices.
Uncertainty Avoidance and the Allocation of Entrepreneurial Activity across Entrepreneurship and Intrapreneurship
Authors: Liebregts W. J. (Werner) , Rigtering J. P. C. (Coen) , Bosma N. S. (Niels) 
Published: December 2024

How uncertainty affects entrepreneurship is a central theme in entrepreneurship research. However, evidence for how a culture of uncertainty avoidance (UA) influences entrepreneurial activity is mixed. Unlike prior research, we theorize and test how UA practices allocate individuals across two modes of opportunity exploitation. Our findings show that uncertainty-avoidant cultures channel individuals toward intrapreneurship rather than entrepreneurship. Moreover, we find a cross-level interaction effect with individuals’ fear of entrepreneurial failure; stronger UA practices direct failure-fearing individuals even more toward intrapreneurship. These findings shed new light on the complex relationship between UA and the prevalence of different forms of entrepreneurial activity. JEL Classification: J24; L26; M13; O43; O57.
Afghan Refugee Women’s Agency in Learning to Read in English
Authors: Hamada Megumi , Riddle Elizabeth M. 
Published: December 2024

This article reports a descriptive case study conducted at a community-based adult English language program over 7 weeks. The participants were three Afghan refugee women, who were at beginning-level proficiency in English without prior education and native language literacy. Although phonics is a recommended approach for beginning-level literacy instruction, its effectiveness depends on how actively learners engage with the instruction. This study investigated the benefits of contextualized phonics-based instruction, focusing also on learner agency (engagement and resistance) during the instruction. Based on analysis of class observation notes, teacher reflections, lesson materials, and pre- and post-test scores, the findings are presented as learner profiles, describing their gains in literacy skills and patterns of engagement and resistance. The patterns of resistance are discussed as the result of the value discrepancy between the teacher and the participants. The article recommends that resistance be viewed as valuable feedback from learners and be incorporated when making instructional decisions.
Near-Normalized Maxillomandibular Relationship and Upper Airway in Infants with Robin Sequence Treated with Stanford Orthodontic Airway Plate: Computed Tomography Study
Authors: Ahn HyoWon , Choi Yoon Jeong , Baek Wooyeol , Kim Ha-Young , Chang Pi En , Choo HyeRan 
Published: December 2024

Objective To assess craniofacial and upper airway growth in infants with Robin sequence (RS) during the 1st year of life when their severe upper airway obstruction was treated non-surgically with the Stanford orthodontic airway plate treatment program (SOAP). Design Retrospective longitudinal cohort study comparing SOAP-treated infants with RS (treatment group) with age-matched healthy controls (HC) using computed tomography (CT). Setting Single tertiary referral hospital. Patients Twelve SOAP-treated infants with RS. Interventions SOAP. Main Outcome Measures Craniofacial skeletal cephalometric parameters and three-dimensional airway metrics. Results No infants required mandibular distraction or tracheostomy surgery after SOAP. The pre-treatment CT was acquired at the mean age (±SD) of 1.3 months (±0.7). The treatment lasted for 4.8 months (±0.9). Post-treatment CT was acquired at 12.9 months (±2.3) of age. The pre-treatment obstructive apnea hypopnea index decreased from 29.21 events/hour (±14.80) to 4.11 events/hour (±2.21) at post-treatment. The total mandibular length increased from 40.58 mm (±2.98) to 62.15 mm (±2.77) at post-treatment (p < 0.001) resulting in the growth velocity of 51.02% (±11.20) or 20.52 mm (±3.95) per year. The maxillary and mandibular lengths of the treatment group at post-treatment were shorter than those of HC although the maxillomandibular relationship was not different (p = 0.618). The upper airway volume and minimal cross-sectional area were also not different (p = 0.083, p = 0.254, respectively). Conclusions The maxillomandibular relationship and upper airway of the SOAP-treated infants with RS were near-normalized at post-treatment, comparable to age-matched healthy infants.
Cytomegalovirus viremia and hepatitis B reactivation in patient with RET fusion-positive non-small cell lung cancer treated with pralsetinib
Authors: Lehman Alanna , Perissinotti Anthony , Aitken Sam 
Published: December 2024

Introduction Mutated rearranged during transfection (RET) kinase is found in approximately 1–2% non-small-cell lung cancer (NSCLC) patients. These patients are typically younger, non-smokers, and have non-squamous histology. Pralsetinib is a novel RET inhibitor that showed promising efficacy and tolerability in the ARROW trial. Due to the small percentage of patients that have RET mutated NSCLC, real world data on safety is still needed. Case report This case report outlines a patient who was initiated on pralsetinib for RET mutated NSCLC and subsequently developed reactivation of cytomegalovirus (CMV) viremia and hepatitis B. Management and outcome The patient was initiated on valganciclovir and entecavir with subsequent improvement in viral loads. They were able to reinitiate pralsetinib at a lower dose following improvement of CMV and hepatitis B viral load with continuation of entecavir. Discussion RET is responsible for activation of several signaling paths including PI3K/AKT and JAK/STAT. Those pathways are involved in the immune system. When reviewing current JAK inhibitors and PI3K inhibitors on the market, there is mixed data on HBV reactivation and CMV viremia, though theoretically possible. Therefore, this should be evaluated and addressed in further studies. The educational value of this case could provide valuable insights for baseline monitoring and management for similarly effected patients.
A Novel Training Modality for Providers in the Emergency Department Using a Computer-Based Scenario: A Pilot Study
Authors: Kehler Stephanie A. , Abufarsakh Bassema , Seng Sarret , Okoli Chizimuzo T. C. 
Published: December 2024

Background: Individuals with substance use disorders (SUD) are increasingly admitted in emergency departments (EDs) nationwide. However, ED providers often have limited knowledge about and lack confidence in treating SUDs. This limited knowledge often results in poor treatment outcomes among patients with SUD in the ED setting. Aims: The aims of this pilot study were to (a) assess the desirability, applicability, and acceptability of a computer-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) education scenario and (b) examine changes in SUD knowledge scores among ED providers before and after engaging in the computer-based SBIRT education scenario. Methods: A tailored computer-based education scenario was developed based on the SBIRT framework for ED providers in an academic medical center. Participants ( N = 15) evaluated the desirability, applicability, and acceptability of the education tool. Also, a single-group pre-/post-design was used to examine changes in participants’ SUD knowledge and proficiency scores. Results: Participants rated the computer-based SBIRT education scenario as desirable, applicable, and acceptable based on 4.0/5.0 or greater evaluation scores for each component. Overall knowledge scores increased from 3.5 to 3.8, albeit non-significantly. Proficiency score percentages increased by 25%. Conclusion: Computer-based SBIRT education scenario training may be acceptable by ED providers and may improve proficiency in addressing SUD for patients. Future studies should evaluate this training method with a larger sample size.
Mental burden of ocular surface discomfort
Authors: Di Zazzo Antonio , De Gregorio Chiara , Spelta Sara , Demircan Senol 
Published: December 2024

Objective This research investigates the associations between Dry Eye Disease (DED), pain perception, and mental health, focusing on how neuropathic pain influences treatment efficacy and patients’ quality of life. Methods and Results The study delves into the complexity of DED by assessing the correlation between ocular pain, depression, PTSD, and systemic pain conditions. It highlights the role of chronic neuropathic pain in DED and the nociceptive hypothesis, which suggests that psychological stress can exacerbate DED symptoms. Additionally, it explores diagnostic and management strategies for DED, emphasizing the importance of considering psychological aspects to improve patient care. Conclusions The intricate nature of DED, closely linked to mental health issues, requires a comprehensive diagnostic and therapeutic approach. Addressing neuropathic pain and psychological factors is crucial for effective DED management. Future efforts should focus on developing specific interventions targeting DED's physical and emotional impacts to enhance overall patient well-being.
Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort
Authors: Giovannoni Gavin , Boyko Alexey , Correale Jorge , Edan Gilles , Freedman Mark S , Montalban Xavier , Rammohan Kottil , Stefoski Dusan , Yamout Bassem , Leist Thomas , Aydemir Aida , Borsi Laszlo , Verdun di Cantogno Elisabetta 
Published: December 2024

Background: CLASSIC-MS explored long-term outcomes of patients treated with cladribine tablets. Objective: Assess long-term efficacy in patients previously enrolled in ORACLE-MS, a Phase III parent trial. Methods: ORACLE-MS included patients with a first clinical demyelinating event (FCDE or clinically isolated syndrome) who received ⩾1 course of cladribine tablets or placebo. With a median follow-up time of 9.5 years, CLASSIC-MS assessed conversion rates to clinically definite multiple sclerosis (CDMS), time-to-conversion, relapse rates, long-term mobility/disability status and subsequent disease-modifying therapy (DMT) use. Results: Of 227 patients from the ORACLE-MS cohort of 616, 68.7% were exposed to cladribine tablets and 31.3% were never exposed. Of the exposed patients at risk, 51.5% converted to CDMS with a median conversion time of 8.4 (95% confidence interval (CI): 5.4–not estimable) years, versus 80.6%, median time 0.8 (95% CI: 0.3–2.4) years, for never exposed. Exposed patients were less likely to be using a wheelchair or ambulatory device or receive subsequent DMTs, and 53.2% were relapse-free versus 28.2% never exposed. Conclusions: Proportionally, more FCDE patients exposed to cladribine tablets experienced delayed conversion to CDMS and fewer relapses and were less likely to use a wheelchair or ambulatory device than never-exposed patients, at 9.5 years (median).
The effect of telehealth on clinical outcomes in patients with hypertension and diabetes: A meta-analysis of 106,261 patients
Authors: Kelly Francinny Alves , Moraes Francisco Cezar Aquino de , Lôbo Artur de Oliveira Macena , Sano Vitor Kendi Tsuchiya , Souza Maria Eduarda Cavalcanti , Almeida Artur Menegaz de , Kreuz Michele , Laurinavicius Antônio Gabriele , Consolim-Colombo Fernanda Marciano 
Published: December 2024

Introduction Telemedicine, propelled by recent technological advancements, has transformed healthcare delivery, notably benefiting patients with chronic non-communicable diseases (NCDs) such as systemic arterial hypertension and diabetes mellitus. This meta-analysis of randomized clinical trials aimed to assess the efficacy of telehealth-based interventions on disease control rates and clinical parameters among NCD patients, including systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose (FBG), and glycated hemoglobin (HbA1c) levels. Methods We conducted searches in PubMed, Scopus, Web of Science, and the Cochrane Database for interventional studies that compared tele-monitoring with usual care in patients with hypertension and type 2 diabetes mellitus. Odds ratios with 95% confidence intervals (CIs) were computed. Results Our meta-analysis included 75 studies, encompassing a total of 106,261 patients, with 50,074 (47.12%) receiving usual care and 56,187 (52.88%) receiving tele-monitoring care. The telemedicine group was associated with a statistically significant reduction in SBP (mean difference (MD) −4.927 mmHg; 95% CI −6.193 to −3.660; p < 0.001; I² = 90%), DBP (MD −2.019 mmHg; 95% CI −2.679 to −1.359; p < 0.001; I² = 54%), FBG (MD −0.405 mmol/L; 95% CI −0.597 to −0.213; p < 0.001; I² = 32%), and HbA1c (MD −0.418%; 95% CI −0.525 to −0.312; p < 0.001; I² = 76%). Conclusions Our meta-analysis shows that telehealth technologies notably enhance blood pressure and blood glucose control. This supports integrating telemedicine into clinical protocols as a valuable complementary tool for managing hypertension and diabetes mellitus comprehensively.
Research on structural vertical stiffness evaluation of track-specific suspension bridge under the action of the no-load first train
Authors: Li Xiaogang , Cen Sihan , Ding Peng , Chen Xiaohu , Huang Xiangsheng , Luo Haoran 
Published: December 2024

The track-specific bridge has the characteristics of a large volume of passenger traffic, narrow transverse width, and large excitation. The long-term and high-frequency operating conditions put forward strict requirements for the safety and comfort of the bridge. Aiming at the problem of achieving fast, accurate, and intelligent evaluation of bridges under the coupling action of trains and temperatures, this paper proposes a method for evaluating the structural vertical stiffness of track-specific suspension bridges under the action of the no-load first train. Firstly, the [Formula: see text] (deformation-velocity-time) data of trains on the bridge are analyzed through linkage numerical simulation, track train transponder, and structural safety monitoring system. Secondly, the CART algorithm establishes a regression model for data correction. The mapping relationship between the modified deformation monitoring value and the theoretical calculation value is analyzed to realize the current structural vertical stiffness evaluation. Finally, it is verified by the world’s largest span self-anchored track-specific suspension bridge. The results show that the theoretical deformation value of the most unfavorable deformation section is 268.55 mm, the actual monitoring value is 232.80 mm, the difference is 35.75 mm, and the relative error is 13.3%. The R2 score of the CART regression model is 0.94, and the accuracy of the CART regression model is higher than that of other algorithm regression models. The modified dynamic check coefficient is less than 1, and the ratio of the modified residual deformation value to the maximum deformation value is 7.6%, which meets the specification requirement not exceeding 20%, indicating that the current structural vertical stiffness is in normal operating conditions.
Long-term Outcomes of the AcoArt II–BTK Trial: Drug-Coated Balloon Angioplasty Compared With Uncoated Balloons for the Treatment of Infrapopliteal Artery Lesions
Authors: Sun Guoyi , Liu Jie , Jia Xin , Xiong Jiang , Ma Xiaohui , Zhang Hongpeng , Guo Wei 
Published: December 2024

Purpose: Previous studies have indicated mixed short-term outcomes between drug-coated balloon (DCB) angioplasty and percutaneous transluminal angioplasty (PTA) in the treatment of infrapopliteal lesions. However, the long-term durability of DCB angioplasty remains uncertain. The objective of this study is to present the long-term outcomes of DCB angioplasty for infrapopliteal lesions in patients with critical limb ischemia (CLI). Materials and Methods: The AcoArt II–BTK Trial was a prospective, multicenter, randomized, single-blinded trial that enrolled 120 patients with CLI. The patients were randomized 1:1 to DCB angioplasty or PTA. Assessments over 5 years included freedom from all-cause death, freedom from clinically driven target lesion revascularization, and occurrence of major amputation. Additional endpoints included the rate of composite major adverse events. Results: Over 5 years, patients treated with DCB angioplasty demonstrated a higher rate of freedom from all-cause death than patients treated with PTA (Kaplan-Meier estimate 74.6% vs 57.2%; log-rank p=0.04). The major amputation rate was 5.2% for DCB angioplasty compared with 1.8% for PTA (log-rank p=0.347). Freedom from clinically driven target lesion revascularization was 70.5% and 53.7%, respectively (log-rank p=0.058). The rate of composite major adverse events was 34.5% for DCB angioplasty and 56.1% for PTA (log-rank p=0.013), and this statistically significant difference persisted throughout the 5-year follow-up period. Conclusion:Infrapopliteal artery revascularization in patients with CLI using Litos/Tulip DCB angioplasty showed superior 5-year overall survival compared with PTA. The DCB angioplasty group had a consistently lower rate of major adverse events within 5 years of follow-up. Clinical Impact The use of DCB in infrapopliteal arterial lesions has been controversial regarding both early and mid-term outcomes, with limited data on long-term results. However, this article demonstrates that the Litos/Tulip DCB exhibits favorable long-term outcomes in infrapopliteal artery lesions. These positive findings provide robust evidence supporting the use of DCB in treating infrapopliteal artery disease.