bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling Ariadne’s Thread Into the Labyrinth of aMCI
Authors: Giannouli Vaitsa , Tsolaki Magda 
Published: November 2020

Background:
People with amnestic mild cognitive impairment (aMCI) face many daily challenges as memory loss is their predominant cognitive impairment.

Objectives:
This study examined whether financial capacity can be influenced by comorbid depression in patients with multiple-domain aMCI.

Materials and Methods:
The participants included 120 patients in 4 groups: multiple-domain aMCI with and without depressive symptoms, and nondemented elders with and without depression. Participants were examined with the Mini-Mental State Examination, the 15-item Geriatric Depression Scale, and the Legal Capacity for Property Law Transactions Assessment Scale.

Results:
The findings extend earlier work in other groups of older patients and indicate that the performance of patients with multiple-domain aMCI in cognitive functioning and financial capacity is severely impaired when depression coexists, resembling the performance of patients with mild Alzheimer disease.

Conclusions:
The results support special care for individuals with depression as this condition severely influences financial capacity in aMCI.
Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study
Authors: Yu Jian , Huang Yongheng , Quan Chao , Zhou Lei , ZhangBao Jingzi , Wu Kaicheng , Zong Yuan , Zhou Xujiao , Wang Min 
Published: November 2020

Background:
To determine retinal vessel density in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Methods:
Twenty-five patients with MOGAD and 20 healthy participants were enrolled. Patients with MOGAD were divided into myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-positive eyes with a history of optic neuritis (ON; MOG-Ab-ON+ group) or without a history of ON (MOG-Ab-ON− group). Visual function, retinal vessel densities, and thickness were measured.

Results:
The retinal nerve fiber layer, parafoveal ganglion cell and inner plexiform layers, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the MOG-Ab-ON+ eyes compared with healthy eyes and MOG-Ab-ON− eyes (all P < 0.05). An increasing number of ON episodes was associated with greater decreases in these variables (all P < 0.05). Visual field mean deviation was not significantly decreased in patients with a history of 1 or 2 episodes of ON, although the relative decreases in retinal nerve fiber layer thickness, parafoveal ganglion cell and inner plexiform layer thickness, peripapillary vessel density, and parafoveal vessel density reached 33.1%, 23.2%, 17.0%, and 11.5% (all P < 0.05), respectively, in eyes with 2 episodes of ON. The mean deviation was significantly correlated with peripapillary vessel density (P < 0.05) after adjustment for other variables. Best-corrected visual acuity was not significantly correlated with optical coherence tomography variables (all P > 0.05).

Conclusions:
MOG-Ab-associated ON was associated with significant decreases in retinal structure and vessel density, without significant deteriorations in visual function. The peripapillary vessel density might predict the visual outcomes in patients with MOG-Ab-associated ON.
Neurosarcoidosis and Ocular Inflammation: A Case Series and Literature Review
Authors: Desai Aishwary , Chaon Benjamin , Berkenstock Meghan 
Published: November 2020

Objective:
To describe the ocular findings of neurosarcoidosis (NS) through a case series and review the current literature on the ocular complications of NS.

Methods:
Case series of 4 patients with a literature review.

Results:
Ophthalmic involvement in NS includes scleritis, cranial nerve palsies, uveitis, optic nerve granulomas, and occlusive retinal vasculitis.

Conclusion:
NS is an uncommon, but potentially life-threatening, manifestation of sarcoidosis with ocular involvement up to 25% of patients. Patients presenting with neuro-ophthalmic manifestations of sarcoidosis are more likely to have other sites of involvement requiring ophthalmologists to maintain a high index of suspicion for systemic disease.
Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic
Authors: Medicherla Chaitanya B. , Pauley Rachel A. , de Havenon Adam , Yaghi Shadi , Ishida Koto , Torres Jose L. 
Published: November 2020

Background:
Recent studies have noted concern for increased thromboembolic events in the setting of Coronavirus Disease 2019 (COVID-19). Cerebral venous sinus thrombosis (CVST) is a form of thromboembolism that has been observed as a neuro-ophthalmologic complication of COVID-19.

Methods:
Review of the scientific literature.

Results:
In this article, we report an overview of CVST epidemiology, clinical presentation, diagnostics, disease pathophysiology, and management in the setting of COVID-19.

Conclusion:
CVST is an uncommon thromboembolic event with variable phenotypes and multiple etiologies. Neurologic complications can be severe, including significant visual deficits and death. Current observations suggest that the risk of CVST may be profoundly impacted by this novel COVID-19 pandemic, thus prompting increased attention to disease presentation, pathogenesis, and management.
Segmental Imaging of the Trochlear Nerve: Anatomic and Pathologic Considerations
Authors: Agarwal Nivedita , Ahmed Ali Karim , Wiggins Richard H. , McCulley Timothy J. , Kontzialis Marinos , Macedo Leonardo L. , Choudhri Asim F. , Ditta Lauren C. , Ishii Masaru , Gallia Gary L. , Aygun Nafi , Blitz Ari M. 
Published: November 2020

Background:
The trochlear nerve (the fourth cranial nerve) is the only cranial nerve that arises from the dorsal aspect of the midbrain. The nerve has a lengthy course making it highly susceptible to injury. It is also the smallest cranial nerve and is often difficult to identify on neuroimaging.

Evidence Acquisition:
High-resolution 3-dimensional skull base MRI allows for submillimeter isotropic acquisition and is optimal for cranial nerve evaluation. In this text, the detailed anatomy of the fourth cranial nerve applicable to imaging will be reviewed.

Results:
Detailed anatomic knowledge of each segment of the trochlear nerve is necessary in patients with trochlear nerve palsy. A systematic approach to identification and assessment of each trochlear nerve segment is essential. Pathologic cases are provided for each segment.

Conclusions:
A segmental approach to high-resolution 3-dimensional MRI for the study of the trochlear nerve is suggested.
Integrative research perspectives on marine conservation
Authors: Hillebrand Helmut , Jacob Ute , Leslie Heather M. 
Published: November 2020

Whereas the conservation and management of biodiversity has become a key issue in environmental sciences and policy in general, the conservation of marine biodiversity faces additional challenges such as the challenges of accessing field sites (e.g. polar, deep sea), knowledge gaps regarding biodiversity trends, high mobility of many organisms in fluid environments, and ecosystem-specific obstacles to stakeholder engagement and governance. This issue comprises contributions from a diverse international group of scientists in a benchmarking volume for a common research agenda on marine conservation. We begin by addressing information gaps on marine biodiversity trends through novel approaches and technologies, then linking such information to ecosystem functioning through a focus on traits. We then leverage the knowledge of these relationships to inform theory aiming at predicting the future composition and functioning of marine communities. Finally, we elucidate the linkages between marine ecosystems and human societies by examining economic, management and governance approaches that contribute to effective marine conservation in practice.
This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Linking dimensions of data on global marine animal diversity
Authors: Webb Thomas J. , Vanhoorne Bart 
Published: November 2020

Recent decades have seen an explosion in the amount of data available on all aspects of biodiversity, which has led to data-driven approaches to understand how and why diversity varies in time and space. Global repositories facilitate access to various classes of species-level data including biogeography, genetics and conservation status, which are in turn required to study different dimensions of diversity. Ensuring that these different data sources are interoperable is a challenge as we aim to create synthetic data products to monitor the state of the world's biodiversity. One way to approach this is to link data of different classes, and to inventory the availability of data across multiple sources. Here, we use a comprehensive list of more than 200 000 marine animal species, and quantify the availability of data on geographical occurrences, genetic sequences, conservation assessments and DNA barcodes across all phyla and broad functional groups. This reveals a very uneven picture: 44% of species are represented by no record other than their taxonomy, but some species are rich in data. Although these data-rich species are concentrated into a few taxonomic and functional groups, especially vertebrates, data are spread widely across marine animals, with members of all 32 phyla represented in at least one database. By highlighting gaps in current knowledge, our census of marine diversity data helps to prioritize future data collection activities, as well as emphasizing the importance of ongoing sustained observations and archiving of existing data into global repositories.This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
The crossover from microscopy to genes in marine diversity: from species to assemblages in marine pelagic copepods
Authors: Laakmann Silke , Blanco-Bercial Leocadio , Cornils Astrid 
Published: November 2020

An accurate identification of species and communities is a prerequisite for analysing and recording biodiversity and community shifts. In the context of marine biodiversity conservation and management, this review outlines past, present and forward-looking perspectives on identifying and recording planktonic diversity by illustrating the transition from traditional species identification based on morphological diagnostic characters to full molecular genetic identification of marine assemblages. In this process, the article presents the methodological advancements by discussing progress and critical aspects of the crossover from traditional to novel and future molecular genetic identifications and it outlines the advantages of integrative approaches using the strengths of both morphological and molecular techniques to identify species and assemblages. We demonstrate this process of identifying and recording marine biodiversity on pelagic copepods as model taxon. Copepods are known for their high taxonomic and ecological diversity and comprise a huge variety of behaviours, forms and life histories, making them a highly interesting and well-studied group in terms of biodiversity and ecosystem functioning. Furthermore, their short life cycles and rapid responses to changing environments make them good indicators and core research components for ecosystem health and status in the light of environmental change.This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Acoustic indexes for marine biodiversity trends and ecosystem health
Authors: Pieretti Nadia , Danovaro Roberto 
Published: November 2020

Acoustic approaches have been recently proposed to investigate critical ecological issues, such as biodiversity loss and different typologies of impacts, including climate change. However, the extensive use of acoustic monitoring is hampered by the lack of algorithms enabling the discrimination among different sound sources (e.g. geophysical, anthropogenic and biological). Eco- and bioacoustic indexes have been applied to provide non-invasive information on the temporal and spatial patterns of marine biodiversity and on the anthropogenic impact on marine life. Here, we review the potential of acoustic tools in expanding the monitoring of marine ecosystems from a current three-dimensional perception to a four-dimensional dimension. We also explore the use of acoustic indexes, mostly developed in terrestrial ecology, for the investigation of different marine ecosystems. Their appraisal, strengths and limits, and potential for future investigations in the biological exploration of the oceans are also discussed.
This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Projecting marine developmental diversity and connectivity in future oceans
Authors: Marshall Dustin J. , Alvarez-Noriega Mariana 
Published: November 2020

Global change will alter the distribution of organisms around the planet. While many studies have explored how different species, groups and traits might be re-arranged, few have explored how dispersal is likely to change under future conditions. Dispersal drives ecological and evolutionary dynamics of populations, determining resilience, persistence and spread. In marine systems, dispersal shows clear biogeographical patterns and is extremely dependent on temperature, so simple projections can be made regarding how dispersal potentials are likely to change owing to global warming under future thermal regimes. We use two proxies for dispersal—developmental mode and developmental duration. Species with a larval phase are more dispersive than those that lack a larval phase, and species that spend longer developing in the plankton are more dispersive than those that spend less time in the plankton. Here, we explore how the distribution of different development modes is likely to change based on current distributions. Next, we estimate how the temperature-dependence of development itself depends on the temperature in which the species lives, and use this estimate to project how developmental durations are likely to change in the future. We find that species with feeding larvae are likely to become more prevalent, extending their distribution poleward at the expense of species with aplanktonic development. We predict that developmental durations are likely to decrease, particularly in high latitudes where durations may decline by more than 90%. Overall, we anticipate significant changes to dispersal in marine environments, with species in the polar seas experiencing the greatest change.This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Life in fluctuating environments
Authors: Bernhardt Joey R. , O'Connor Mary I. , Sunday Jennifer M. , Gonzalez Andrew 
Published: November 2020

Variability in the environment defines the structure and dynamics of all living systems, from organisms to ecosystems. Species have evolved traits and strategies that allow them to detect, exploit and predict the changing environment. These traits allow organisms to maintain steady internal conditions required for physiological functioning through feedback mechanisms that allow internal conditions to remain at or near a set-point despite a fluctuating environment. In addition to feedback, many organisms have evolved feedforward processes, which allow them to adjust in anticipation of an expected future state of the environment. Here we provide a framework describing how feedback and feedforward mechanisms operating within organisms can generate effects across scales of organization, and how they allow living systems to persist in fluctuating environments. Daily, seasonal and multi-year cycles provide cues that organisms use to anticipate changes in physiologically relevant environmental conditions. Using feedforward mechanisms, organisms can exploit correlations in environmental variables to prepare for anticipated future changes. Strategies to obtain, store and act on information about the conditional nature of future events are advantageous and are evidenced in widespread phenotypes such as circadian clocks, social behaviour, diapause and migrations. Humans are altering the ways in which the environment fluctuates, causing correlations between environmental variables to become decoupled, decreasing the reliability of cues. Human-induced environmental change is also altering sensory environments and the ability of organisms to detect cues. Recognizing that living systems combine feedback and feedforward processes is essential to understanding their responses to current and future regimes of environmental fluctuations.This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Modern models of trophic meta-communities
Authors: Gross Thilo , Allhoff Korinna T. , Blasius Bernd , Brose Ulrich , Drossel Barbara , Fahimipour Ashkaan K. , Guill Christian , Yeakel Justin D. , Zeng Fanqi 
Published: November 2020

Dispersal and foodweb dynamics have long been studied in separate models. However, over the past decades, it has become abundantly clear that there are intricate interactions between local dynamics and spatial patterns. Trophic meta-communities, i.e. meta-foodwebs, are very complex systems that exhibit complex and often counterintuitive dynamics. Over the past decade, a broad range of modelling approaches have been used to study these systems. In this paper, we review these approaches and the insights that they have revealed. We focus particularly on recent papers that study trophic interactions in spatially extensive settings and highlight the common themes that emerged in different models. There is overwhelming evidence that dispersal (and particularly intermediate levels of dispersal) benefits the maintenance of biodiversity in several different ways. Moreover, some insights have been gained into the effect of different habitat topologies, but these results also show that the exact relationships are much more complex than previously thought, highlighting the need for further research in this area.This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture
Authors: Hu Yanmei , Ma Chunlong , Szeto Tommy , Hurst Brett , Tarbet Bart , Wang Jun 
Published: November 2020

AbstractAs the COVID-19 pandemic continues to fold out, the morbidity and mortality are increasing daily. Effective treatment for SARS-CoV-2 is urgently needed. We recently discovered four SARS-CoV-2 main protease (Mpro) inhibitors including boceprevir, calpain inhibitors II and XII and GC-376 with potent antiviral activity against infectious SARS-CoV-2 in cell culture. Despite the weaker enzymatic inhibition of calpain inhibitors II and XII against Mprocompared to GC-376, calpain inhibitors II and XII had more potent cellular antiviral activity. This observation promoted us to hypothesize that the cellular antiviral activity of calpain inhibitors II and XII might also involve the inhibition of cathepsin L in addition to Mpro. To test this hypothesis, we tested calpain inhibitors II and XII in the SARS-CoV-2 pseudovirus neutralization assay in Vero E6 cells and found that both compounds significantly decreased pseudoviral particle entry into cells, indicating their role in inhibiting cathepsin L. The involvement of cathepsin L was further confirmed in the drug time-of-addition experiment. In addition, we found that these four compounds not only inhibit SARS-CoV-2, but also SARS-CoV, MERS-CoV, as well as human coronaviruses (CoVs) 229E, OC43, and NL63. The mechanism of action is through targeting the viral Mpro, which was supported by the thermal shift binding assay and enzymatic FRET assay. We further showed that these four compounds have additive antiviral effect when combined with remdesivir. Altogether, these results suggest that boceprevir, calpain inhibitors II and XII, and GC-376 are not only promising antiviral drug candidates against existing human coronaviruses, but also might work against future emerging CoVs.
Generalized neural decoders for transfer learning across participants and recording modalities
Authors: Peterson Steven M. , Steine-Hanson Zoe , Davis Nathan , Rao Rajesh P. N. , Brunton Bingni W. 
Published: November 2020

AbstractObjectiveAdvances in neural decoding have enabled brain-computer interfaces to perform increasingly complex and clinically-relevant tasks. However, such decoders are often tailored to specific participants, days, and recording sites, limiting their practical long-term usage. Therefore, a fundamental challenge is to develop neural decoders that can robustly train on pooled, multi-participant data and generalize to new participants.ApproachWe introduce a new decoder, HTNet, which uses a convolutional neural network with two innovations: (1) a Hilbert transform that computes spectral power at data-driven frequencies and (2) a layer that projects electrode-level data onto predefined brain regions. The projection layer critically enables applications with intracranial electrocorticography (ECoG), where electrode locations are not standardized and vary widely across participants. We trained HTNet to decode arm movements using pooled ECoG data from 11 of 12 participants and tested performance on unseen ECoG or electroencephalography (EEG) participants; these pretrained models were also subsequently fine-tuned to each test participant.Main resultsHTNet outperformed state-of-the-art decoders when tested on unseen participants, even when a different recording modality was used. By fine-tuning these generalized HTNet decoders, we achieved performance approaching the best tailored decoders with as few as 50 ECoG or 20 EEG events. We were also able to interpret HTNet’s trained weights and demonstrate its ability to extract physiologically-relevant features.SignificanceBy generalizing to new participants and recording modalities, robustly handling variations in electrode placement, and allowing participant-specific fine-tuning with minimal data, HTNet is applicable across a broader range of neural decoding applications compared to current state-of-the-art decoders.
Accelerated Simulation of Large Reaction Systems Using a Constraint-Based Algorithm
Authors: Burke Paulo E. P. , Costa Luciano da F. 
Published: November 2020

AbstractSimulation of reaction systems has been employed along decades for a better understanding of such systems. However, the ever-growing gathering of biological data implied in larger and more complex models that are computationally challenging for current discrete-stochastic simulation methods. In this work, we propose a constraint-based algorithm to simulate such reaction systems, called the Constraint-Based Simulation Algorithm (CBSA). The main advantage of the proposed method is that it is intrinsically parallelizable, thus being able to be implemented in GPGPU architectures. We show through examples that our method can provide valid solutions when compared to the well-known Stochastic Simulation Algorithm (SSA). An analysis of computational efficiency showed that the CBSA tend to outperform other considered methods when dealing with a high number of molecules and reaction channels. Therefore, we believe that the proposed method constitutes an interesting alternative when simulating large chemical reaction systems.