bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma
Authors: Munari Fernanda Franco , Sichero Laura , Cruvinel-Carloni Adriana , Lacerda Croider Franco , Nunes Emily Montosa , Oliveira Antônio Talvane Torres de , Scapulatempo-Neto Cristovam , Silva Sandra Regina Morini da , Crema Eduardo , Adad Sheila Jorge , Rodrigues Maria Aparecida Marchesan , Henry Maria Aparecida Coelho Arruda , Guimarães Denise Peixoto , Reis Rui Manuel , Villa Luisa Lina , Longatto-Filho Adhemar 
Published: March 2020

Abstract
Background Chagasic megaesophagus (clinical manifestation of chagasic disease) has been reported as an etiological factor for squamous cell carcinoma of the esophagus, as well as the presence of human papillomavirus (HPV). Objective We accessed the prevalence of HPV DNA in a series of squamous cell carcinomas of the esophagus associated or not with the chagasic megaesophagus, and within samples of chagasic megaesophagus without cancer. Data obtained was further correlated to the pathological clinical data of affected individuals. Methods Retrospective study that used a total 92 samples tissue/biopsy specimens of formalin fixed and paraffin embedded tissues were retrospectively collected from the southeast region of Brazil from patients treated in three hospitals: Barretos Cancer Hospital, Barretos, São Paulo; Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais; and São Paulo State University (UNESP), Botucatu, São Paulo. Cases were divided in three groups: i) 24 patients with chagasic megaesophagus associated with esophageal ESCC (CM/ESCC); ii) 37 patients with esophageal ESCC without chagasic megaesophagus (ESCC); iii) 31 patients with chagasic megaesophagus without esophageal ESCC (CM). Results We detected a higher prevalence of high-risk HPVs in patients from both CM (12/31, 38.8%) and CM/ESCC groups (8/24, 33.3%), as compared to individuals of the ESCC group (6/37, 16.3%), although data was not statistically significant. We further observed that HPV-16 was more prevalent in patients of the ESCC (4/9, 44.5%) and CM/ESCC groups (2/8, 25.0%). In addition, some of these samples presented infection by multiple HPV types. High-risk HPVs detected were HPV-31, 45, 51, 53, 56, 66, and 73, of which the majority was identified in patients from the CM group. Furthermore, low-risk HPV-11 and HPV-70 were identified in individuals from both ESCC and CM groups. Conclusion This is the first report regarding the presence of HPV DNA in megaesophagus associated with esophageal squamous cell carcinoma. In the present study, HPV infection appears to be directly related to the development of esophageal squamous cell carcinoma in patients with chagasic megaesophagus. Further studies are warrantee to confirm and better understand the role of oncogenic HPV persistent infection in these patients.
Correlation of giant earthquakes with the lunar phase in seven Indo-Pacific subduction zones and around Mongolia
Authors: Fujii Yoshiaki , Tsuboi Yusuke , Kodama Jun-ichi , Fukuda Daisuke 
Published: March 2020

Abstract
Variation in the approximately semidiurnal tidal force affects earthquake occurrence. This paper statistically demonstrates that giant earthquakes occur at lunar phases specific to particular seismic zones. Careful observation during the lunar cycle, especially when seismicity is occurring, should significantly reduce the damage from giant earthquakes. A case study in which a giant earthquake occurred after seismicity was concentrated within the specific lunar phase is discussed.
TNIK swaths AR to WNT pathway and drives Castration-Resistant Prostate Cancer
Authors: Jiang Ning , Guo Tao , Wang Miaomiao , Liao Yihao , Ma Fuling , Gao Jie , Wang Youzhi , Wang Keke , Wu Yudong , Morales Amilcar Flores , Niu Yuanjie 
Published: March 2020

Abstract
Background: The development of CRPCa was driven by complex genetic and epigenetic mechanisms that remained poorly understood. TNIK (Traf2 and Nck-interacting kinase) has been reported to be a serine/threonine kinase and associated with tumor cell proliferation or unfavorable cancer behavior. The present study was conducted to investigate the TNIK gene expressions in CRPCa. Methods: Using a microarray approach, we identified higher expression of TNIK in CRPCa. The interaction between AR and H3K27me3 upon TNIK depression was determined through molecular and cell biological methods. Co-immunoprecipitations assays were Performed to confirm that TNIK interacted and phosphorylated with β-catenin in CRPCa cell. Results: Specifically we found AR repressed TNIK gene transcription via forming complex with H3K27me3. TNIK was recruited to promote transcription of Wnt target genes in a β-catenin-dependent manner in C4-2 cells. In vitro binding showed that TNIK directly band and phosphorylated β-catenin. Depletion or mutant of TNIK kinase abrogated β-catenin transcription, highlighting the essential function of TNIK kinase activity in Wnt target gene activation. Conclusions: Our findings revealed a regulatory role of AR in TNIK repressor, TNIK interacted with β-catenin and phosphorylated activaing Wnt pathway to promote CRPCa progression. TNIK may present an attractive candidate for drug targeting in CRPCa.
Testy kontroli jakości obrazowania kV-CBCT z wykorzystaniem fantomu Capthan 504 oraz ich analiza z użyciem oprogramowania Artiscan.
Authors: Szweda Hubert 
Published: March 2020

Radioterapia kontrolowana za pomocą obrazowania (ang. Image Guided Radiotherapy – IGRT) w ostatnich latach stała się szeroko akceptowalną i zalecaną techniką leczenia. Możliwość precyzyjnego obrazowania pacjenta bezpośrednio przed podaniem wiązki terapeutycznej pozwala na bardzo dokładne sprawdzenie jego ułożenia, precyzyjne napromienienie obszaru tarczowego oraz zmniejszenie dawki promieniowania deponowanej w zdrowych tkankach i narządach. Głównym celem pracy było wykonanie testów kontroli jakości systemu obrazowania kV-CBCT zainstalowanego na medycznym akceleratorze liniowym TrueBeam, firmy Varian Medical Systems. Celem szczegółowym było wyznaczenie wartości referencyjnych dla wszystkich testów obrazowania oraz opracowanie protokołów QA (ang. Quality Assurance). Do przeprowadzenia testów kontroli jakości wykorzystano fantom Catphan 504. Dokonano kontroli jakości dwóch protokołów skanowania: Head oraz Pelvis. Podczas testów wyznaczono następujące parametry opisujące jakość obrazu: liniowość skali jednostek Hounsfielda, rozdzielczość wysokokontrastową, rozdzielczość niskokontrastową, zniekształcenie geometryczne, poziom szumu, jednorodność. Do analizy uzyskanych obrazów DICOM wykorzystano oprogramowanie Artiscan. Poziom szumu w obrazie wynosił 2,75% dla protokołu skanowania Head i 0,85% dla protokołu Pelvis, natomiast jednorodność obrazu wynosiła 94% i 98%. Wszystkie obliczone wartości jednostek HU mieściły się w przyjętym przedziale tolerancji. Rozdzielczość wysokokontrastowa wynosiła kolejno 7,70lp/mm i 5,59lp/mm. Dla protokołu skanowania Pelvis, obiekt o średnicy 15mm w warunkach Supra-Slice 1% został wykryty podczas każdej serii pomiarowej. Nie zaobserwowano żadnych zniekształceń geometrycznych obrazu. Opracowane protokoły kontroli jakości używane są w praktyce klinicznej podczas procesu kontroli jakości.
The factors affecting achievement national examination in high schools
Authors: Susilowati Nenden , Sukidjo Sukidjo 
Published: March 2020

This research aims to reveal the factors affecting the achievement in the national examination. This study was analytical research. The population in this study totaled 2,243, whereas the amount of the specified sample was 339 students with techniques of stratified random sampling. The population in this study totaled 2, 243, whereas the amount of the specified samples of 339 students with techniques of stratified random sampling. The data collected through a questionnaire, observation, and documentation. The data analysis used the multiple regression model. The research results are as follows. Significant; (1) there is a significant correlation of the intake of students on the national exam results. The value is of R is 0.740; (2) there is a significant correlation between the learning motivation of students on the national exam results. The value of R is 0.406; (3) there, significant is significant Correlation of the competency of teachers on the National exam results; the value of R is 0.398; (4) there is a significant correlation of the school environment on the national exam results; the value of R is 0. 366; (5) there is a significant correlation of the family support on the national is exam results; the value of R is 0.443; (6) there is a significant correlation of the intake of students ' learning motivation, the competence of teachers, school environment, and family support simultaneously on the national exam is results of the results; the value of R is 0.825.
LATAR BELAKANG ASPEK KEHIDUPAN PADA SISTEM PENAMAAN JALAN DI KOTA YOGYAKARTA: KAJIAN ANTROPOLINGUISTIK
Authors: Prihadi Prihadi , Listiyorini Ari 
Published: March 2020

Penelitian mengenai onomastika telah beberapa kali dilakukan. Lewat penelitian onomastika dapat dijelaskan penggunaan aspek kebahasaan dan aspek lain seperti sejarah dan budaya, kehidupan, motivasi, serta alasan motivasi dan tujuan penamaan tersebut. Penelitian ini bertujuan untuk mendeskripsikan aspek kehidupan pada sistem penamaan jalan di Yogyakarta sebagai bagian dari keistimewaan Daerah Istimewa Yogyakarta. Penelitian ini menggunakan desain penelitian deskriptif. Penelitian dibatasi pada Kota Yogyakarta yang memiliki data nama jalan secara formal. Data berupa nama-nama jalan. Sumber data berupa sumber data tertulis dan lisan. Teknik pengumpulan data dengan observasi, wawancara, dan pencatatan. Analisis data dengan kultural-historis. Validasi dilakukan dengan triangulasi data dan metode. Penelitian menemukan 26 aspek kehidupan yang selanjutnya dapat dikelompokkan menjadi 9 aspek kehidupan. Aspek-aspek tersebut meliputi aspek tumbuhan dan binatang, aspek tempat (asal-usul tempat, fungsi tempat, penanda tempat, dan arah tempat), aspek yang berhubungan dengan keraton (kerabat keraton, prajurit keraton, tempat tinggal pegawai keraton, senjata perang), aspek geografis (ciri-ciri geografis, gunung/sungai, dan fenomena alam), aspek profesi, aspek pahlawan dan tokoh, aspek harapan dan cita-cita, aspek nama wayang, dan aspek lainnya (aktivitas kerja, karakter, dan sifat). Kata kunci: nama jalan, aspek kehidupan, kultural-historis BACKGROUNDS OF THE LIFE ASPECTS ON THE ROAD NAMING SYSTEM IN YOGYAKARTA CITY: ANTHROPOLINGUISTIC STUDYAbstract Research on onomastics has been conducted a number of times. Through onomastic research, road naming can be described in terms of the linguistic and other aspects such as history and culture, ways of life, and motives and objectives. This study is aimed at describing the aspects of life in the street naming system in Yogyakarta as part of the special features of the Yogyakarta Special Region. This study uses the descriptive research design. The research location in Yogyakarta is limited to the city of Yogyakarta which has formal road name data. Data are in the form of street names in the study location. Data sources are written and oral. Data collection techniques are observation, interview, and recording. Data analysis is cultural-historical. Validation is done by data and method triangulations. Results show 26 aspects of life grouped into 9. These aspects are related to plants and animals, places (origin, function, marker, and direction), palaces (family kinship, soldier troop, official residence, and war weapon), geography (feature, mountain/river, and natural phenomena), profession, hero and figure, hope and ideal, wayang figure, and other (work activity, character, and nature). Keywords: street names, aspects of life, cultural-historical aspect
One-Way and Two-Way Mobile Phone Text Messages for Treatment Adherence Among Patients With HIV: Protocol for a Randomized Controlled Trial
Authors: Nsagha Dickson Shey , Siysi Vincent Verla , Ekobo Same , Egbe Thomas Obinchemti , Kibu Odette Dzemo 
Published: March 2020

Background
Incomplete adherence to antiretroviral therapy (ART) is one of the factors that contribute to HIV drug resistance, and it is a major problem for the public health system in controlling the HIV pandemic. There is emerging evidence that SMS can play an important role in health care delivery among patients with HIV on ART, especially in resource-limited settings.

Objective
This paper aims to assess the impact of two-way and one-way SMS text messaging on adherence to HIV treatment. We hypothesized that sending weekly text messages through the one-way and two-way SMS text messaging approach will improve adherence to ART among patients with HIV and improve associated clinical outcomes (quality of life).

Methods
A randomized controlled trial is being carried out among participants with HIV who have been on ART for at least one month from an accredited treatment center, namely the Buea Regional Hospital and Kumba District Hospital of South West Region, Cameroon. Participants with HIV, both male and female, aged 21 years and older make up a sample size of 207. The interventions involved the use of mobile phone text messages. Before commencing the intervention, a focus group discussion was carried out among the participants to understand their perception about the use of SMS-based interventions to improve adherence. A total of 246 participants were randomized to receive either a one-way text message (SMS sent to a recipient without recipient sending a reply) or two-way text message (SMS sent to a recipient and recipient sends a reply) or the control (no SMS, only standard care). Data on adherence and quality of life were collected at baseline and after 6 months and will be analyzed using SPSS version 21, while qualitative data will be analyzed using Atlas.ti 7.5.

Results
Data collection began in September 2019 with focus group discussions and baseline data collection. After 1 month of baseline data collection, the intervention began in October 2019, and postintervention data were collected after 6 months (March 2020). At the end of the study, we will be able to understand the perception of patients toward SMS text messaging–based interventions and also assess the impact of one-way and two-way SMS text messages on treatment adherence among patients with HIV and on associated clinical outcomes (quality of life).

Conclusions
The impact of SMS text messaging varies across different settings. The results from this study will determine the perception of patients toward an SMS text messaging–based intervention and its impact on adherence to ART.

International Registered Report Identifier (IRRID)
DERR1-10.2196/16127
Engaging Patients and Professionals to Evaluate the Seriousness of Maternal and Child Health Outcomes: Protocol for a Modified Delphi Study
Authors: Bodnar Lisa M , Khodyakov Dmitry , Himes Katherine P , Burke Jessica G , Parisi Sara , Hutcheon Jennifer A 
Published: March 2020

BackgroundMaternal weight gain during pregnancy is one of the few potentially modifiable risk factors for many adverse maternal and child health outcomes. Defining the optimal pregnancy weight gain range is difficult because, while lower weight gain may prevent some outcomes, such as maternal and child obesity, it may increase the risk of others such as fetal growth restriction and infant death. These health outcomes vary in their seriousness to mothers and their health care providers, and these differences in seriousness should be taken into account when determining optimal weight gain ranges. However, the relative seriousness that women and their care providers place on different health outcomes is unknown.ObjectiveWe will determine the seriousness of 11 maternal and child health outcomes that have been consistently associated with pregnancy weight gain. We will achieve this by engaging patients and maternal and child health professionals using an online modified Delphi panel process.MethodsWe aim to recruit a racially/ethnically and geographically diverse group of 90 US maternal and child health professionals and 90 women who are pregnant or less than 2 years postpartum. We will conduct 3 concurrent panels using the ExpertLens system, a previously evaluated online modified Delphi system that combines 2 rounds of rating with 1 round of feedback and moderated online discussion. In Round 1, panelists are asked to rate the seriousness of each health outcome on a scale of 0-100 and to provide a rationale for their scores. In Round 2, panelists will review their responses relative to those of other panelists. They will discuss their seriousness ratings anonymously using a moderated online discussion board. In Round 3, participants will revise their Round 1 responses based on group feedback and discussion. Each round will be open for 1-2 weeks.ResultsThe study protocol was reviewed by our ethics boards and did not require approval as human research. A pilot study of 6 professionals and 7 patients was completed in December 2019.ConclusionsOur numeric estimates of the seriousness of maternal and child health outcomes will enable future studies to determine pregnancy weight gain ranges that balance the risks of low and high weight gain for mothers and children.International Registered Report Identifier (IRRID)DERR1-10.2196/16478
Midwives’ Attitudes Toward and Experience With a Tablet Intervention to Promote Safety Behaviors for Pregnant Women Reporting Intimate Partner Violence: Qualitative Study
Authors: Garnweidner-Holme Lisa , Henriksen Lena , Flaathen Eva Marie , Klette Bøhler Tone , Lukasse Mirjam 
Published: March 2020

Background
Violence against women is considered a global health problem, and intimate partner violence (IPV) around the time of childbirth can have severe consequences for mother and child. Prenatal care is considered a window of opportunity to address IPV and ask women about exposure to violence since women are in regular contact with health care providers. Mobile health (mHealth) interventions might overcome the barriers to talking about IPV face-to-face.

Objective
Our objective was to explore midwives’ attitudes toward a tablet intervention consisting of information about IPV and safety behaviors as well as their experiences with recruiting pregnant women of different ethnic backgrounds in a randomized controlled trial (RCT).

Methods
Individual interviews were conducted with 9 midwives who recruited participants for an RCT to test a video to promote safety behaviors delivered on a tablet during prenatal care. Analysis was guided by thematic analysis.

Results
Midwives perceived the tablet intervention as an appropriate supplement during prenatal care to provide information about IPV and promote safety behaviors. They participated in the RCT primarily to obtain more knowledge regarding how to communicate about IPV. The intervention was perceived as an anonymous door-opener to talk about IPV and a good solution to ensure that every woman gets the same information. However, the content of the intervention had to be trustworthy and align with the information the midwives provide to women. Given the sensitivity of IPV, midwives outlined the importance of following the intervention with face-to-face communication. Midwives reported technical problems and a high demand on their time as the main challenges to recruiting women. They experienced challenges recruiting women of different ethnic backgrounds due to linguistic barriers and the women’s skepticism about scientific research.

Conclusions
The tablet intervention might help midwives communicate about IPV. Although the video was considered as an anonymous door-opener to talk about IPV, midwives outlined the importance of following the intervention with face-to-face communication. The scarcity of midwives’ time during consultations has to be considered when implementing the intervention. Further research is needed to overcome barriers that limit inclusion of women from different ethnic backgrounds.

Trial Registration
ClinicalTrials.gov NCT03397277; https://clinicaltrials.gov/ct2/show/NCT03397277
Effect of a Health System–Sponsored Mobile App on Perinatal Health Behaviors: Retrospective Cohort Study
Authors: Cawley Caroline , Buckenmeyer Hannelore , Jellison Trina , Rinaldi Joseph B , Vartanian Keri B 
Published: March 2020

Background
Pregnancy mobile apps are becoming increasingly popular, with parents-to-be seeking information related to their pregnancy and their baby through mobile technology. This increase raises the need for prenatal apps with evidence-based content that is personalized and reliable. Previous studies have looked at whether prenatal apps impact health and behavior outcomes among pregnant and postpartum individuals; however, research has been limited.

Objective
The primary objective of this study is to assess whether the use of a health system–sponsored mobile app—Circle by Providence—aimed at providing personalized and reliable health information on pregnancy, postpartum recovery, and infant care is associated with improved health outcomes and increased healthy behaviors and knowledge among users.

Methods
This observational study compared app users and app nonusers using a self-reported survey and electronic medical records. The study took place over 18 months and was conducted at Providence St. Joseph Health in Portland, Oregon. The sample included patients who received prenatal care at one of seven Providence clinics and had a live birth at a Providence hospital. Recruitment occurred on a rolling basis and only those who completed the survey were included. Survey respondents were separated into app users and app nonusers, and survey responses and clinical outcomes were compared across groups using univariate and adjusted multivariate logistic regression.

Results
A total of 567 participants were enrolled in the study—167 in the app user group and 400 in the nonuser group. We found statistically significant differences between the two groups for certain behavior outcomes: subjects who used the app had 75% greater odds of breastfeeding beyond 6 months postpartum (P=.012), were less likely to miss prenatal appointments (P=.046), and were 50% more likely to exercise 3 or more times a week during pregnancy (P=.04). There were no differences in nutritional measures, including whether they took prenatal vitamins, ate 5 fruits or vegetables a day, or drank caffeine. We found no differences in many of the infant care outcomes; however, there was an increase in awareness of “purple crying.” Finally, there were no significant differences in measured clinical health outcomes, including cesarean births, length of hospital stays (in minutes), low birth weight infants, preterm births, small-for-gestational-age births, large-for-gestational-age births, and neonatal intensive care unit stays.

Conclusions
The use of the Circle app, which provides access to personalized and evidence-based health information, was associated with an increase in certain healthy behaviors and health knowledge, although there was no impact on clinical health outcomes. More research is needed to determine the impact of mobile prenatal apps on healthy pregnancies, clinical health outcomes, and infant care.