bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of preoperative carbohydrate intake on inflammatory factors and clinical outcomes in elderly patients undergoing radical prostatectomy: a single-center, double-blind randomized controlled trial
Authors: Hu Zhen , Liu Ji , Ma Wenchao , Wang Fen 
Published: June 2020

Abstract
BACKGROUND

To investigate the advantages of Carbohydrate (CHO) in inflammatory factors, comfort and clinical outcomes in elderly patients with open radical prostatectomy.
METHODS

Patients of ≥ 65 years old with radical prostatectomy who underwent open radical prostatectomy were randomized to the CHO group, placebo group, and conventional water-blocking group. Patients in the CHO group and placebo group received oral CHO, 800 ml of placebo water before surgery,and oral CHO and placebo water 400 ml 2 to 3 hours before surgery; the water-free group did not drink any liquid. The main test indicators are inflammatory factors, comfort and clinical outcomes.
RESULTS

28 patients in the CHO group, 30 in the placebo group, and 32 in the conventional water-blocking group were included in the study. The three groups matched well in age, body mass index, the grade of (American Society of Anesthesiologists)ASA, operation time, blood loss, and fluid volume.CHO reduces IL-6 of Day1 and Day7 (P = 0.009, 0.005, respectively), IL-8 (P = 0.005) of Day1, Day1, Day 3, and Day 7 TNF (P = 0.001, 0.006, 0.003 respectively) compared with the water-stopping group ; placebo water reduced Day 1 and Day 7 TNF (P = 0.005, 0.038, respectively), Day 1of IL-8 (P = 0.045). CHO reduced Day3 of TNF (P = 0.026) compared to placebo. In the CHO group and the placebo group, the morning thirst scores (0.68, 1.26, respectively) and starvation (0.24, 0.47, respectively)were decreased. The first time to leave bed in the conventional water-blocking group (39.21 (15–93) h) was much later than in the CHO group (28.57 (10–100) h) and the placebo group (28.71 (12–70) h).
Conclusion

Compared with routine water ban, preoperative CHO and placebo water can reduce the levels of IL-6, IL-8 and TNF in elderly patients undergoing radical prostatectomy, which can improve the patient's preoperative comfort and shorten the patient's first time to leave bed. Compared with placebo water, CHO has no significant advantage in improving inflammatory factors and clinical outcomes.
Changes in malaria patterns in Brazil over 28 years (1990-2017): results from the Global Burden of Disease Study 2017
Authors: Bezerra Juliana Maria Trindade , Barbosa David Soeiro , Martins-Melo Francisco Rogerlândio , Werneck Guilherme Loureiro , Braga Érika Martins , Tauil Pedro Luiz , Carneiro Mariângela 
Published: June 2020

Abstract
Background
This study presents the malaria burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), by analyzing disease burden indicators in federated units of the Legal Amazon and Extra Amazon regions, as well as describing malaria cases according to Plasmodium species occurring in the country.
Methods
We used estimates from the GBD 2017 to report years of life lost due to premature death (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for malaria in Brazil, grouped by gender, age group, and Brazilian federated unit, from 1990 to 2017. Results are presented as absolute numbers and age-standardized rates (per 100,000 inhabitants) with 95% uncertainty intervals (UI).
Results
At the national level, the age-standardized DALYs rate due to malaria decreased by 92.0%, from 42.5 DALYs per 100,000 inhabitants (95% UI 16.6–56.9) in 1990 to 3.4 DALYs per 100,000 inhabitants (95% UI 2.7–4.7) in 2017. The YLLs were the main component of the total DALYs rate for malaria in 1990 (67.3%), and the YLDs were the main component of the metric in 2017 (61.8%). In 2017, the highest sex-age DALYs rate was found among females in the “<1 year old” age group, with a 6.4 DALYs per 100,000 inhabitants (95% UI 1.8–14.7) and among males in the age group of “20 to 24 years old”, with a 4.7 DALYs per 100,000 inhabitants (95% UI 3.3–9.9). Within the Brazilian Amazon region, the three federated units with the highest age-standardized DALYs rates in 2017 were Acre [28.4 (95% UI 14.2–39.1)], Roraima [28.3 (95% UI 13.5–40.2)], and Rondônia [24.7 (95% UI 11.4–34.8)]. Concerning the parasite species that caused malaria, 73.5% of the total of cases registered in the period had Plasmodium vivax as the etiological agent.
Conclusions
The results of the GBD 2017 show that despite the considerable reduction in the DALYs rates between 1990 and 2017, malaria remains a relevant and preventable disease, which in recent years has generated more years of life lost due to disability than deaths. The states endemic for malaria in the Amazon region require constant evaluation of preventive and control measures. The present study will contribute to the direction of current health policies aimed at reducing the burden of malaria in Brazil, as knowing the geographical and temporal distribution of the risk of death and disability of this disease can facilitate the planning, implementation and improvement of control strategies aimed at eliminating the disease.
Indian vaccine decision-makers’ conceptualization and fostering of ‘community engagement’: A qualitative analysis of elite interviews
Authors: Dutta Tapati , Meyerson Beth , Agley Jon , Barnes Priscilla , Sherwood-Laughlin Catherine , Nicholson-Crotty Jill 
Published: June 2020

Abstract
Background: Vaccination literature highlights programmatic and ethical pertinence of ‘community engagement’ in ensuring efficacious vaccines becoming effective vaccinations. However, lack of consensual definition of community engagement, recurring evidence of community backlashes especially during vaccine introductions, and paucity of literature on community engagement’s effectiveness in achieving vaccination outcomes is problematic because assuming a shared understanding of community engagement will only lead to erroneous assumptions about its value, or lack thereof. This study examines conceptualization of community engagement by vaccine decisionmakers in India and efforts to foster it during the Decade of Vaccines.Methods: Elite interviews were carried out (December 2017 to February 2018) with 25 national-level vaccine decisionmakers in India. Study participants included policymakers, immunization program heads, and vaccine technical committee leads representing Government, international non-profits, and donors. Using Schutz’ Social Phenomenological theory, an a priori framework guided coding decisionmakers’ conceptualizations of ‘communities’, ‘community engagement’, and fostering the same. NVivo12 was used for data analysis placing exemplar community engagement interventions on a low to high spectrum. Findings were validated in a one-day member check-in meeting with study participants and teams. Results: Barring themselves, decisionmakers defined ‘communities’ as vaccine-eligible children, their parents, frontline healthcare workers, and vaccination influencers namely- religious leaders, and members of local youth clubs and non-profits. ‘Community engagement’ was variously defined as vaccine outreach, capacity-building of healthcare workers, and information dissemination to guardians of vaccine-eligible children. There was no explicit policy guideline defining community engagement, and no metrics assessing its effectiveness in vaccination uptake. Participants agreed that ‘community engagement’ though evolving is a complex and under-researched area. Community engagement spectrum exemplified seven intersecting layers, with ‘low’ as ‘vaccine impositions’, and ‘high’ as ‘community’s vaccination decision-making’. Participants in the member check-in meeting proposed an operational definition of community engagement and discussed gaps/concerns related to defining/implementing it.Conclusions: It is critical to build-in the operational definition of community engagement in vaccine guidelines, develop its performance and outcome indicators, and advocate their incorporation in immunization surveillance instruments in India. Acknowledging relational gains of community engagement is pertinent to improve vaccination outcomes in India and is relevant for consideration by other countries too.
Psychological Distress among Iranian Health-Care Providers Exposed to Coronavirus Disease 2019 (COVID-19): A Qualitative Study
Authors: Alizadeh Azizeh , Khankeh Hamid Reza , Barati Mohammad , Ahmadi Yazdan , Hadian Arash , Azizi Maryam 
Published: June 2020

Abstract
Background
Novel corona virus pneumonia, named COVID-19, has spread rapidly to other countries like Italy, Iran and South Korea and affected all people, especially health-care providers. Therefore, due to the rapid spread of the disease in Iran, the aim of the present study was to explore psychological distress experienced by Iranian health-care providers in the first few weeks of the corona virus outbreak.
Methods
The present qualitative study was conducted on 18 Iranian health-care providers exposed to COVID − 19 using a content analysis method. Purposeful sampling was used to select the participants and continued until data saturation was reached. Data were collected using semi-structured interviews and then the qualitative data were analyzed through direct content analysis.
Results
By analyzing 236 primary codes, three main categories, including demands, job resources and individual resources were extracted from the experiences of health-care providers during corona virus outbreak. These categories each included several sub-categories, which were classified according to their significant characteristics.
Conclusions
.Psychological protection of health care workers is an important component in addressing the COVID-19 epidemic. Understanding the health care providers’ experiences and their mental health demands during public health emergency might help medical workers and managers to response better to a disaster.
Epitope‐based peptide vaccine design against spike protein (S) of novel coronavirus (2019-nCoV): an immunoinformatics approach
Authors: Awadelkareem Eman Ali , Mohammed Nisreen Osman , Gaafar Bothina Bakor Mohammed , Abdelmagid Zahra - , Ali Sumaia AwadElkariem 
Published: June 2020

Abstract
Background

Recently the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has generated a significant need on identifying drugs or vaccines to prevent or reduce clinical infection of Coronavirus disease – 2019 (COVID-19). In this study, immuno-informatics tools were utilized to design a potential multi-epitopes vaccine against SARS-CoV-2 spike S protein. Structural analysis for SARS-CoV-2 spike S protein was also conducted.
Method:

SARS-CoV-2 spike S protein sequences were retrieved from the GeneBank of National Central Biotechnology Information (NCBI). Immune Epitope Database (IEDB) tools were used to predict B and T cell epitopes, to evaluate their allergenicity, toxicity and cross- reactivity and to calculate population coverage. Protparm sever was applied to determine protein characterization of spike protein and predicted epitopes. Molecular docking for the proposed MHCI epitopes were also achieved against Tall like Receptor (TLR8) receptors and HLA-B7 allele.
Result

Immuno-informatics analysis of S protein using IEDB identified only one B cell epitope 1054QSAPH1058 as linear, surface and antigenic. Although 1054QSAPH1058 was estimated as non-allergic and non-toxic, it showed protein instability. Moreover, around 45 discontinuous epitopes were also recognized as different exposed surface area. In MHCI methods, six conserved stable and safe epitopes (898FAMQMAYRF906, 258WTAGAAAYY266 and 2FVFLVLLPL10, 202 KIYSKHTPI210, 712IAIPTNFTI720 and 1060VVFLHVTYV1068) were identified. These epitopes showed strong interaction when docked with TLR8 and HLA-B7 allele especially 1060VVFLHVTYV1068 and 2FVFLVLLPL10 epitopes. Three epitopes were also predicted (898FAMQMAYRF906, 888FGAGAALQI896 and 342FNATRFASV350) using MHCII methods. Furthermore, the potential multi-epitopes were acquired by assessing allergenicity, toxicity and cross-reactivity to prevent autoimmunity.
Conclusion

The multi-epitopes vaccine was predicted based on Bioinformatics tools that may provide reliable results in a shorter time and at a lower cost. However, further in vivo and in vitro studies are required to validate their effectiveness.
Assessment of the Quality of Antenatal Care Services and the Associated Risk Factors in Tanzania
Authors: Hussein Abdalla , Mbishi Jackline 
Published: June 2020

Abstract
Background

This study gives the finding of the assessment made on the quality of antenatal care (ANC) services received by women in Tanzania during pregnancy and the associated risk factors.
Methods

We used the data from the 2015-16Tanzania Demographic and Health Survey and Malaria Indicator Survey (TDHS-MIS). The sample included 6,924 women who gave birth in the five years before the survey and having at least one ANC visit in the most current pregnancy. The quality of ANC services provided was assessed using six questions on receipt of recommended components of ANC services. The responses of the individual components were summed up to generate the ANC service provision score. In so doing, the women who received all six components were considered to receive good quality ANC services. A weighted logistic regression model was employed in the examination of the factors associated with the quality of ANC services.
Results

The average service provision score was 4.4 out of a total of 6. Approximately, 31% of the women received good quality ANC services. The most provided ANC components were blood sample measurement (87%) and iron tablets/syrup (82.1%). The urine sample (60%) was the least offered ANC service. The results of the adjusted logistic regression model revealed that age, place of residence, education level, the time of the first ANC visit, number of ANC visits, and family wealth index were significant factors associated with the quality of ANC services.
Conclusions

In terms of service provision, the quality of ANC service in Tanzania is suboptimal. With differences by observed risk factors, there must be more efforts to strengthen the quality of ANC services and to remove the differences.
Predictive equations for evaluation for resting energy expenditure in Brazilian patients with type 2 diabetes: What can we use?
Authors: Grassi Thaiciane , Boeno Francesco Pinto , de Freitas Mauren Minuzzo , de Paula Tatiana Pedroso , Viana Luciana Vercoza , de Oliveira Alvaro Reischak , Steemburgo Thais 
Published: June 2020

Abstract
Background: Evaluation of the resting energy expenditure (REE) is essential to ensure an appropriate dietary prescription for patients with type 2 diabetes. The aim of this record was to evaluate the accuracy of predictive equations for REE estimation in patients with type 2 diabetes, considering indirect calorimetry (IC) as the reference method.Methods: A cross-sectional study was performed in outpatients with type 2 diabetes. Clinical, body composition by electrical bioimpedance and, laboratory variables were evaluated. The REE was measured by IC (QUARK RMR, Cosmed, Rome, Italy) and estimated by eleven predictive equations. Data were analyzed using Bland–Altman plots, paired t-tests, and Pearson’s correlation coefficients.Results: 62 patients were evaluated [50% female; mean age 63.1 ± 5.2 years; diabetes duration of 11 (1-36) years, and mean A1C of 7.6 ± 1.2%]. There was a wide variation in the accuracy of REE values predicted by equations when compared to IC REE measurement. In all patients, Ikeda and Mifflin St-Jeor equations were that most underestimated REE. And, the equations that overestimated the REE were proposed by Dietary Reference Intakes and Huang. The most accurate equations were FAO/WHO/UNO in women (-1.8% difference) and Oxford in men (-1.3% difference).Conclusion: In patients with type 2 diabetes, in the absence of IC, FAO/WHO/UNO and Oxford equations provide the best REE prediction in comparison to measured REE for women and men, respectively.
Knowledge, attitude, and practices (KAP) towards COVID-19 among Nepalese residents during the COVID-19 outbreak: An online cross-sectional study
Authors: Paudel Sachina , Shrestha Prabin , Karmacharya Isha , Pathak Om Krishna 
Published: June 2020

Abstract
Background.

The objective of this study was to assess the knowledge, attitude and practices of COVID-19 among Nepalese population, as containment of the disease is only possible with the change in behaviours as preventive measures.
Methodology.

A web-based cross-sectional survey was conducted for a period of two month among Nepalese residents aged ≥ 18 years using a previously validated tool. Unrestricted self-selected, convenient sampling method was adopted to generate a heterogeneous sample. Data were analysed in SPSS version 22 using chi-square/Fisher-exact test, independent t-test, multiple linear regression and binary logistic regression.
Results.

Out of 766 participants, 78.3% were aged 20–39 years and 58.2% were residents of province 3. One-third of the respondents were students followed by health workers. The rates for correct answer for COVID-19 knowledge questionnaire ranged from 30–99% with health workers and participants with bachelor’s degree having significantly better knowledge. Of the total participants, 71.5% agreed that COVID-19 will be effectively controlled and 80% were assured that Nepal could win the fight against COVID-19. The majority of the participants had not visited any crowded place (93.1%) which was significantly associated with age, marital status, gender, education, occupation, province of residence, and knowledge score of COVID-19 and 92.4% participants wore masks while going out which significantly differed across gender.
Conclusion.

There is a need to provide education and awareness about COVID-19 to Nepalese people focusing on the areas of knowledge gap so that Nepal can have victory against COVID-19.
Early predictive factors of progression from severe type to critical ill type in patients with Coronavirus Disease 2019: A retrospective cohort study
Authors: Li Nan , Kong Hao , Zheng Xi-Zi , Li Xue-Ying , Ma Jing , Zhang Hong , Wang Dong-Xin , Li Hai-Chao , Liu Xin-Min 
Published: June 2020

Abstract
Background: The current worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, and the mortality rate of critical ill patients remains high. The purpose of this study was to identify factors that early predict the progression of COVID-19 from severe to critical illness.Methods: This retrospective cohort study included adult patients with severe or critical ill COVID-19 who were consecutively admitted to the Zhongfaxincheng campus of Tongji Hospital (Wuhan, China) from February 8 to 18, 2020. Baseline variables, data at hospital admission and during hospital stay, as well as clinical outcomes were collected from electronic medical records system. The primary endpoint was the development of critical illness. A multivariable logistic regression model was used to identify independent factors that were associated with the progression from severe to critical illness.Results: A total of 138 patients were included in the analysis; of them 119 were diagnosed as severe cases and 16 as critical ill cases at hospital admission. During hospital stay, 19 more severe cases progressed to critical illness. For all enrolled patients, longer duration from diagnosis to admission (odds ratio [OR] 1.108, 95% CI 1.022-1.202; P=0.013), pulse oxygen saturation at admission <93% (OR 5.775, 95% CI 1.257-26.535; P=0.024), higher neutrophil count (OR 1.495, 95% CI 1.177-1.899; P=0.001) and higher creatine kinase-MB level at admission (OR 2.449, 95% CI 1.089-5.511; P=0.030) were associated with a higher risk, whereas higher lymphocyte count at admission (OR 0.149, 95% CI 0.026-0.852; P=0.032) was associated with a lower risk of critical illness development. For the subgroup of severe cases at hospital admission, the above factors except creatine kinase-MB level were also found to have similar correlation with critical illness development.Conclusions: Higher neutrophil count and lower lymphocyte count at admission were early independent predictors of progression to critical illness in severe COVID-19 patients.
Effect of extra-virgin olive oil on lipid profile and inflammatory biomarkers in patients undergoing coronary angiography: a randomized, controlled, clinical trial
Authors: Khandouzi Nafiseh , Zahedmehr Ali , Nasrollahzadeh Javad 
Published: June 2020

Abstract
Background

Olive oil, rich in mono-unsaturated fatty acid and the main fat in the Mediterranean diet, has long been considered to be favorable for cardiovascular health. The present study was conducted to compare the effects of high polyphenol extra-virgin olive oil (EVOO) with low polyphenol refined olive oil (ROO) on some cardiovascular risk factors in patients undergoing coronary angiography.
Methods

In a randomized, controlled, parallel-arm, clinical trial, 40 patients (aged 54.83 ± 7.04 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred to coronary angiography were randomly allocated to two groups and received 25 mL EVOO (n = 20) or ROO (n = 20) daily for 6 weeks. Fasting blood was collected and plasma lipids, malondialdehyde (MDA), C-reactive protein (CRP) as well as, inflammatory cytokines in ex-vivo lipopolysaccharide (LPS)-stimulated whole blood culture were measured at the baseline and after the dietary intervention.
Results

Baseline characteristics were similar between the two groups. Plasma LDL-cholesterol significantly reduced in EVOO group (-9.52 ± 20.44 vs 8.68 ± 18.77 mg/dL, p = 0.007 for EVOO and ROO respectively), whereas total cholesterol/HDL-cholesterol had no significant changes. EVOO resulted in significant reduction in plasma CRP (-0.40 ± 0.52 vs 0.007 ± 0.42 mg/L, p = 0.01 for EVOO and ROO respectively) and increased ex-vivo whole blood LPS-stimulated IL-10 production (12.13 ± 33.64 vs -17.47 ± 49.04 pg/mL, p = 0.035 for EVOO and ROO respectively). However, there were no significant differences in LPS-stimulated IL-6 and plasma MDA levels between the two groups.
Conclusions

Daily consumption of polyphenol-rich EVOO in subjects who have been under medical treatment with risk-reducing agents could additionally improve LDL-C and selected inflammatory markers.
Trial registration:
NCT03796780 at clinicaltrial.gov (12/29/2018)