bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pericarp growth dynamics associate with final grain weight in wheat under contrasting plant densities and increased night temperature
Authors: Herrera Jaime , Calderini Daniel F 
Published: July 2020

Abstract

Background and Aims
The pericarp weight comprises &lt;17 % of wheat grain weight at harvest. The pericarp supports the hydration and nutrition of both the embryo and endosperm during early grain filling. However, studies of the pericarp and its association with final grain weight have been scarce. This research studied the growth dynamics of wheat pericarp from anthesis onwards and its relationship to final grain weight under contrasting plant densities and night warming.

Methods
Two spring wheat cultivars contrasting in kernel weight (Bacanora and Kambara) were sown in field conditions during seasons 2012–13 and 2014–15. Both genotypes were grown under contrasting plant density (control, 370 plants m–2; and low plant density, 44 plants m–2) and night temperatures, i.e. at ambient and increased (&gt;6 °C) temperature for short periods before and after anthesis. From anthesis onward, grains were harvested every 3 or 4 d. Grain samples were measured and the pericarp was removed with a scalpel. Whole grain and pericarp fresh and dry weight were weighed with a precision balance. At harvest, 20 grains from ten spikes were weighed and grain dimensions were measured.

Key Results
Fresh weight, dry matter and water content of pericarp dynamics showed a maximum between 110 and 235 °Cd. Maximum dry matter of the pericarp ranged between 4.3 and 5.7 mg, while water content achieved values of up to 12.5 mg. Maximum values and their timings were affected by the genotype, environmental condition and grain position. Final grain weight was closely associated with maximum dry matter and water content of the pericarp.

Conclusions
Maximum pericarp weight is a determinant of grain weight and size in wheat, which is earlier than other traits considered as key determinants of grain weight during grain filling. Better growing conditions increased maximum pericarp weight, while higher temperature negatively affected this trait.
Birmingham Taking the Initiative: Changes and Challenges in Working Differently with Adults
Authors: Fawcett Barbara , Johnson Miranda , Mould Fiona , Ubhi Jaspreet 
Published: July 2020

Abstract
Turning rhetoric into reality and fully embracing the principles and practice of the Care Act 2014 in innovative, citizen-focused and creative ways has been a journey constructively embraced in Birmingham over the last two years. This has been a journey with critical learning points which incorporate theoretical reflection, managerial and practitioner innovation and an emphasis on citizen-focused co-production. This article considers the context, examines the nature of the change process and appraises the findings from the eighteen-month evaluation. All of these learning points and the process of change itself are eminently transferrable to other Local Authorities operating in the four countries which comprise the UK as well as to the international arena.
Metals and molecular carcinogenesis
Authors: Zhu Yusha , Costa Max 
Published: July 2020

AbstractMany metals are essential for living organisms, but at higher doses they may be toxic and carcinogenic. Metal exposure occurs mainly in occupational settings and environmental contaminations in drinking water, air pollution and foods, which can result in serious health problems such as cancer. Arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr) and nickel (Ni) are classified as Group 1 carcinogens by the International Agency for Research on Cancer. This review provides a comprehensive summary of current concepts of the molecular mechanisms of metal-induced carcinogenesis and focusing on a variety of pathways, including genotoxicity, mutagenesis, oxidative stress, epigenetic modifications such as DNA methylation, histone post-translational modification and alteration in microRNA regulation, competition with essential metal ions and cancer-related signaling pathways. This review takes a broader perspective and aims to assist in guiding future research with respect to the prevention and therapy of metal exposure in human diseases including cancer.
Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists
Authors: Rybak Michael J , Le Jennifer , Lodise Thomas P , Levine Donald P , Bradley John S , Liu Catherine , Mueller Bruce A , Pai Manjunath P , Wong-Beringer Annie , Rotschafer John C , Rodvold Keith A , Maples Holly D , Lomaestro Benjamin 
Published: July 2020

Abstract
Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations. The previous 2009 vancomycin consensus guidelines recommend trough monitoring as a surrogate marker for the target area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC). However, recent data suggest that trough monitoring is associated with higher nephrotoxicity. This document is an executive summary of the new vancomycin consensus guidelines for vancomycin dosing and monitoring. It was developed by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists vancomycin consensus guidelines committee. These consensus guidelines recommend an AUC/MIC ratio of 400–600 mg*hour/L (assuming a broth microdilution MIC of 1 mg/L) to achieve clinical efficacy and ensure safety for patients being treated for serious methicillin-resistant Staphylococcus aureus infections.
Pathological nodal disease defines survival outcomes in patients with lung cancer with tumour major pathological response following neoadjuvant chemotherapy
Authors: Corsini Erin M , Weissferdt Annikka , Pataer Apar , Zhou Nicolas , Antonoff Mara B , Hofstetter Wayne L , Mehran Reza J , Rajaram Ravi , Rice David C , Roth Jack A , Vaporciyan Ara A , Walsh Garrett L , Cascone Tina , Heymach John V , Swisher Stephen G , Sepesi Boris 
Published: July 2020

Abstract

OBJECTIVES

Major pathological response (MPR) is prognostic of outcomes for patients with non-small-cell lung cancer following neoadjuvant chemotherapy and is used as the primary end point in neoadjuvant immunotherapy trials. We studied the influence of pathological nodal disease on patterns and timing of recurrence among patients with MPR.

METHODS
Patients treated with neoadjuvant chemotherapy for stages I–III non-small-cell lung cancer were identified. Surgical specimens were histopathologically examined for tumour viability, categorized as ≤10% viability (MPR) or &gt;10% (NoMPR). Overall survival and disease-free survival were evaluated with emphasis upon MPR and pathological nodal disease.

RESULTS
Among 307 patients, 58 (19%) had MPR within primary tumour and 42 (14%) had MPRypN0. In the MPR group, the frequency of cN0 and cN+ disease was 18 (31%) and 40 (69%); similarly, the frequency of ypN0, ypN1 and ypN2 was 72% (42/58), 16% (9/58) and 12% (7/58), respectively. When evaluating only those with MPR, recurrence rates among those with MPRypN0, MPRypN1 and MPRypN2 were 33% (14/42), 44% (4/9) and 71% (5/7) (P = 0.16). The median time-to-recurrence in MPRypN0, MPRypN1 and MPRypN2 was 40, 10 and 14 months (P = 0.006). Distant recurrences were less common among those with MPRypN0 [MPRypN0, 26% (11/42); MPRypN1, 44% (4/9); MPRypN2, 71% (5/7); P = 0.047]. Though the median disease-free survival was prolonged among those with MPR vs NoMPR (120 vs 25 months, P &lt; 0.0001), only those with MPRypN0 had prolonged disease-free survival in comparison to other groups upon pairwise comparisons, while MPRypN+ experienced no benefit.

CONCLUSIONS
MPRypN0 represents the most favourable surrogate end point following neoadjuvant chemotherapy. Patients with ypN1-2 are at the risk of early recurrence regardless of primary tumour MPR, warranting intensive surveillance and consideration for additional adjuvant therapy. We highlight that MPRypN0 is the most rigorous end point and should be considered as a surrogate end point in future neoadjuvant trials.
Computer-aided indirect bonding versus traditional direct bonding of orthodontic brackets: bonding time, immediate bonding failures, and cost-minimization. A randomized controlled trial
Authors: Czolgosz Izabela , Cattaneo Paolo M , Cornelis Marie A 
Published: July 2020

Summary

Introduction
The primary aim of this randomized controlled trial was to compare the time for bracket bonding using either direct or computer-aided indirect bonding; a secondary aim was to assess immediate bracket debondings and cost minimization.

Methods
Consecutive patients were randomly allocated to two groups (blocks of four, online-generated sequence) using a split-mouth design with a direct and a computer-aided indirect bonding method: group 1 (upper right and lower left quadrants: indirect bonding; upper left and lower right quadrants: direct bonding) or group 2 (opposite situation). The primary outcome was difference in time spent for bonding brackets. The secondary outcome was immediate bracket debondings (at the bonding appointment). Time for indirect bonding was recorded in two steps: digital bracket placement and clinical bonding procedure. Outcome assessment was blinded. Friedman’s ANOVA test was used to assess differences in bonding time. Chi-square test was used to compare immediate debondings. A cost-minimization analysis was undertaken.

Results
Thirty-seven patients were randomized to group 1 or 2. Ten patients were excluded: 15 patients were analyzed in group 1 and 12 in group 2. Clinical chair time for bonding half a mouth was significantly shorter for computer-aided indirect bonding (12 minutes 52 seconds) than for direct bonding (16 minutes 47 seconds) (P &lt; 0.001). When adding the time for digital bracket placement, the total bonding time (28 minutes 14 seconds) was longer for indirect bonding than for direct bonding (P &lt; 0.001). There was no single immediate debonding with the direct bonding method, while 14 brackets were lost with the indirect bonding method (5.1 per cent) (P = 0.0001). Cost-minimization analysis showed that computer-aided indirect bonding was more expensive than direct bonding.

Conclusions
The clinical chair time was significantly shorter for computer-aided indirect bonding than for direct bonding. However, the total bonding time for computer-aided indirect, including digital bracket placement, was longer than for direct bonding. There were significantly more immediate debondings with computer-aided indirect bonding than with direct bonding. Under these conditions, computer-aided indirect bonding was more expensive than direct bonding.

Registration
This trial was retrospectively registered on ClinicalTrials.gov (University of Aarhus Protocol Record 10101).

Protocol
The protocol was not published before trial commencement.
Harvesting the complex pathways of antibiotic production and resistance of soil bacilli for optimizing plant microbiome
Authors: Hou Qihui , Kolodkin-Gal Ilana 
Published: July 2020

ABSTRACT
A sustainable future increasing depends on our capacity to utilize beneficial plant microbiomes to meet our growing needs. Plant microbiome symbiosis is a hallmark of the beneficial interactions between bacteria and their host. Specifically, colonization of plant roots by biocontrol agents and plant growth-promoting bacteria can play an important role in maintaining the optimal rhizosphere environment, supporting plant growth and promoting its fitness. Rhizosphere communities confer immunity against a wide range of foliar diseases by secreting antibiotics and activating plant defences. At the same time, the rhizosphere is a highly competitive niche, with multiple microbial species competing for space and resources, engaged in an arms race involving the production of a vast array of antibiotics and utilization of a variety of antibiotic resistance mechanisms. Therefore, elucidating the mechanisms that govern antibiotic production and resistance in the rhizosphere is of great significance for designing beneficial communities with enhanced biocontrol properties. In this review, we used Bacillus subtilis and B. amyloliquefaciens as models to investigate the genetics of antibiosis and the potential for its translation of into improved plant microbiome performance.
Effectiveness of a Technology-Enhanced Integrated Care Model for Frail Older People: A Stepped-Wedge Cluster Randomized Trial in Nursing Homes
Authors: Kim Hongsoo , Jung Young-il , Kim Gi-Soo , Choi Hyoungshim , Park Yeon-Hwan 
Published: July 2020

Abstract

Background and Objectives
The objective of this study was to evaluate the impact of an information and communication technologies (ICT)-enhanced, multidisciplinary integrated care model, called Systems for Person-centered Elder Care (SPEC), on frail older adults at nursing homes.

Research Design and Methods
SPEC was implemented at 10 nursing homes in South Korea in random order using a stepped-wedge design. Data were collected on all participating older residents in the homes before the first implementation and until 6 months after the last implementation. The 21-month SPEC intervention guided by the chronic care model (CCM) consists of 5 strategies: comprehensive geriatric assessment, care planning, optional interdisciplinary case conferences, care coordination, and a cloud-based ICT tool along with a free messaging app. The primary outcome was quality of care measured by a composite quality indicator (QI) from the interRAI assessment system. Usual care continued over the control periods. Nursing home staff were not blinded to the intervention.

Results
There were a total of 482 older nursing home residents included in the analysis. Overall quality of care measured by the composite QI was significantly improved (adjusted mean difference: −0.025 [95% CI: −0.037 to −0.014, p &lt; .0001]). The intervention effect was consistent in the subgroup analysis by cognition and activities of daily living. There were no important adverse events or side effects.

Discussion and Implications
The SPEC, a CCM-guided, ICT-supported, multidisciplinary integrated care management intervention, can improve the quality of care measured by health and functional outcomes for frail older persons residing in nursing homes with limited health care provision.

Clinical Trials Registration Number
ISRCTN11972147
Towards understanding relationships between atmospheric pressure variations and long-period horizontal seismic data: a case study
Authors: Alejandro A C B , Ringler A T , Wilson D C , Anthony R E , Moore S V 
Published: July 2020

SUMMARYVariations in atmospheric pressure have long been known to introduce noise in long-period (&gt;10 s) seismic records. This noise can overwhelm signals of interest such as normal modes and surface waves. Generally, this noise is most pronounced on the horizontal components where it arises due to tilting of the seismometer in response to changes in atmospheric pressure. Several studies have suggested methodologies for correcting unwanted pressure-induced noise using collocated microbarograph records. However, how applicable these corrections are to varying geologic settings and installation types (e.g. vault versus post-hole) is unclear. Using coefficients obtained by solving for the residuals of these corrections, we can empirically determine the sensitivity of instruments in a specific location to the influences of pressure. To better understand how long-period, pressure-induced noise changes with time and emplacement, we examine horizontal seismic records along with barometric pressure at five different Global Seismographic Network stations, all with multiple broadband seismometers. We also analyse three Streckeisen STS-2 broadband seismometers, which are collocated with a microbarograph, at the Albuquerque Seismological Laboratory. We observe periods of high magnitude-squared-coherence (γ2-coherence; γ2 &gt; 0.8) between the seismic and pressure signals which fluctuate through time, frequency, and even between seismic instruments in the same vault. These observations suggest that these tilt-generated signals are highly sensitive to very local (&lt;10 m) site effects. However, we find that in cases where instruments are not located at a large depth (&lt;100 m), the pressure-induced noise is polarized in a nearly constant direction that is consistent with local topographic features or the geometry of the vault. We also find that borehole instruments at a large depth (&gt;100 m) appear to be unaffected by pressure-loading mechanisms outlined by Sorrells (1971) but possibly by Newtonian attraction. Correlating the induced-noise polarization direction with times of high coherence, we work to identify sensors that are ultimately limited by pressure-induced horizontal noise as well as period bands that can benefit from pressure corrections. We find that while the situation is complex, each sensor appears to have its own unique response to pressure. Our findings suggest that we can determine empirical relationships between pressure and induced tilt on a case by case basis.
Meat intake and cancer risk: prospective analyses in UK Biobank
Authors: Knuppel Anika , Papier Keren , Fensom Georgina K , Appleby Paul N , Schmidt Julie A , Tong Tammy Y N , Travis Ruth C , Key Timothy J , Perez-Cornago Aurora 
Published: July 2020

Abstract

Background
Red and processed meat have been consistently associated with colorectal cancer risk, but evidence for other cancer sites and for poultry intake is limited. We therefore examined associations between total, red and processed meat and poultry intake and incidence for 20 common cancers.

Methods
We analyzed data from 474 996 participants (54% women) in UK Biobank. Participants were aged 37–73 years and cancer-free at baseline (2006–10). Multivariable-adjusted Cox proportional hazards models were used to determine associations between baseline meat intake and cancer incidence. Trends in risk across the baseline categories were calculated, assigning re-measured intakes from a subsample.

Results
During a mean follow-up of 6.9 years, 28 955 participants were diagnosed with malignant cancer. After correction for multiple testing, red and processed meat combined, and processed meat, were each positively associated with colorectal cancer risk [hazard ratio (HR) per 70 g/day higher intake of red and processed meat 1.32, 95% confidence interval 1.14–1.53; HR per 20 g/day higher intake of processed meat 1.18, 1.03–1.31] and red meat was associated with colon cancer risk (HR per 50 g/day higher intake of red meat 1.36, 1.13–1.64). Positive associations of red meat intake with colorectal and prostate cancer, processed meat intake with rectal cancer and poultry intake with cancers of the lymphatic and haematopoietic tissues did not survive multiple testing.

Conclusions
Higher intake of red and processed meat was specifically associated with a higher risk of colorectal cancer; there was little evidence that meat intake was associated with risk of other cancers.
Predictors of Distinct Trajectories of Medical Responsibility in Youth with Spina Bifida
Authors: Kayle Mariam , Chu David I , Stern Alexa , Pan Wei , Holmbeck Grayson N 
Published: July 2020

Abstract

Objective
To determine if there are distinct developmental trajectories of medical responsibility in youth with spina bifida (SB) across ages 8–17 years and to identify condition-related, parental, and family systems predictors of membership in these trajectory groups.

Methods
Participants were 140 youth with SB and their parents who participated in four waves of a longitudinal study across 6 years (ages 8–15 years at Time 1). Multi-method (questionnaires and observed family interactions) and multi-respondent assessments were conducted during home visits.

Results
Findings revealed that there were two distinct developmental trajectories that characterized this sample, with one being labeled “high increasing” (two thirds of the sample) and one labeled “low increasing” (one third of the sample). Most predictor variables were significantly associated with trajectory group membership, with the exception of ethnicity, SES, and measures of conflict. When all significant univariate predictors were included in the same model, only intelligence quotient (IQ), family stress, and gender were retained as significant.

Conclusions
Most youth exhibited relatively rapid increases in responsibility over the course of late childhood and adolescence, but there was a smaller portion of the sample that did not exhibit this type of developmental trajectory. The magnitude of the IQ effect on group differentiation appeared to attenuate the effects of most other predictors. It will be important for clinicians working with youth with SB to recognize that the transfer of medical responsibility from parent to child cannot be expected to unfold in the same manner for all families of youth with SB.
Benign cyst with xanthogranulomatous inflammation involving the transverse colon and the common iliac artery
Authors: Corless Kevin , Samy Amir , Kamil Ahmed , Hogan Aisling Maria 
Published: July 2020

Abstract
Xanthogranulomatous inflammation (XGI) is a rare process. Colonic XGI is extremely rare. We present a case report of XGI arising within an intra-abdominal cyst involving the transverse colon. A 28-year-old man presented with abdominal discomfort. He underwent a computed tomography abdomen–pelvis, which found three subcutaneous collections and a large cystic intra-abdominal structure. The decision was made for resection. Intraoperatively, the cyst originated from the pelvis and was adherent to the surrounding tissues. Histology from the lesion revealed XGI extending into the surrounding tissue. XGI is a rare inflammatory condition. Clinically, it can be difficult to distinguish XGI from an infiltrative malignancy. Therefore, it is usually necessary to obtain a pathological diagnosis of XGI. This case describes an atypical cystic lesion with XGI involving the transverse colon. Although rare, it should be considered in the potential differential diagnosis of an infective or malignant mesenteric cyst.