bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We Are the Poles from Former Yugoslavia.” Transformation Processes Shifted in Time—The Biographical Perspective
Authors: Ligus Rozalia 
Published: November 2019

This paper is based on the first analysis of the 25 narrative interviews collected from March to November 2018 in small local communities in the Lower Silesia Region. All narrators belong to the families that were transferred from the former Yugoslavia in 1946 to the western lands which were incorporated to Poland. The socio-cultural conditions are significant for local development, so I present some features of localism after 1989 when the state transformation processes started. Next, I discuss the narrators’ self-identity dilemmas and make an attempt to conceptualize “migrating biography” as one of the features of living in a postmodern world.
The aim of the whole project, but not described in this article, is to reveal the intergenerational adult learning processes seen from the insider’s perspective, as well as to describe such lives in a psychosocial and cultural context.
Add-on effect of Kinesiotape in patients with acute lateral ankle sprain: a randomized controlled trial
Authors: Shin Jeong-Cheol , Kim Jae-Hong , Nam Dongwoo , Park Gwang-Cheon , Lee Jeong-Soon 
Published: November 2019

Abstract
Background: Evidence on the add-on effect of Kinesiotape (KT) on acupuncture for treating ankle sprains remains insufficient. We assessed the add-on effect of KT on ankle sprains by comparing acupuncture combined with KT (AcuKT) with acupuncture alone in patients with acute lateral ankle sprain (ALAS). Methods: This study was a multicenter, randomized, controlled clinical trial that included a per-protocol analysis of the add-on effect of KT on ALAS. The randomization was software-based and only the assessors were blinded. Sixty participants (20 each from three centers) with Grade I or II ALAS were randomly assigned to acupuncture (n=30) or AcuKT (n=30) group. Both groups received acupuncture treatment once daily, 5 days per week for 1 week. The AcuKT group received additional KT treatment. Visual analog scale (VAS) scores for pain and Foot and Ankle Outcome Score (FAOS) were obtained, and edema measurements were performed at baseline (Week 0), at the end of the intervention (Week 1), and at 4 weeks after intervention (Week 5). The European Quality of Life Five Dimension-Five Level Scale (EQ-5D-5L) measurements were conducted at Week 0, Week 1, Week 5, and Week 26 after the intervention. The number of recurrent ankle sprains was determined at 4, 8, 12, and 26 weeks after the intervention. Results: Fifty-six patients with ALAS completed the trial (AcuKT group, 27; acupuncture group, 29). There were significant changes in VAS score (AcuKT: p<0.001; acupuncture: p<0.001), FAOS (AcuKT: p<0.001; acupuncture: p<0.001), and EQ-5D-5L measurements (AcuKT: p<0.001; acupuncture: p<0.001) within both groups. There were no significant differences between groups in terms of any outcome and in a subanalysis based on symptom severity. Conclusions: These results indicate that AcuKT did not show positive add-on effects of KT on acupuncture in terms of pain reduction, edema, recovery of function, activities of daily living, quality of life, and relapse of ALAS.
Nutritional deficiency and associated factors among new pulmonary tuberculosis patients of Bale Zone Hospitals, Southeast Ethiopia
Authors: Hussien Bedru , Hussen Mohammedaman Mama , Seid Abdulwahhab , Hussen Abduljewad 
Published: November 2019

Abstract
Objective Tuberculosis remains deadliest communicable diseases accountable for health problem among various individuals annually and is related to malnutrition. Addressing nutritional deficiency in Tuberculosis patients is a crucial side of Tuberculosis management programme. Therefore, the aim was to assess the magnitude of nutritional deficiency and associated factors among new pulmonary tuberculosis patients of Bale Zone Hospitals, South-east Ethiopia, 2018. Cross-sectional study design was utilized. Data collection was carried out using structured questionnaires and anthropometric measurements. Body mass index was calculated to see nutritional deficiency. Crude and adjusted odds ratios in conjunction with their corresponding 95% confidence intervals were computed. P-value < 0.05 was thought of to declare a result as statistically associated. Results Prevalence of nutritional deficiency was 63.2 %. The mean Body mass index for all listed participants was 17.86 kg/m2. Employment status of the patients, p-value 0.012 (AOR = 1.82; 95 % CI = 1.14, 2.89) and Khat chewing, p-value 0.02 (AOR = 0.43; 95 % CI = 0.23, 0.85) were factors independently associated with Nutritional Deficiency. Prevalence of Nutritional Deficiency was found to be high. Nutritional support for the impoverished, regular nutritional assessment and dietary counseling are necessary for better treatment outcome and effective Tuberculosis management programme.
The impact of racially-motivated housing discrimination on allostatic load among Indigenous university students
Authors: Currie Cheryl , Motz Takara A. , Copeland Jennifer L 
Published: November 2019

Abstract
Background Allostatic load (AL) is an aggregate measure of wear and tear on the body due to the chronic activation of the stress response system. The goal of this study was to examine the association between racially-motivated housing discrimination and AL score within a sample of Indigenous university students.Methods Data for this cross-sectional study were collected from Indigenous adults attending university in a small city in western Canada between 2015 and 2017 ( N = 104; Mean age = 27.8 years). An item adapted from the Experience of Discrimination Scale was to assess racially-motivated housing discrimination in the past 12 months. AL was measured as a composite of 7 biomarkers assessing neuroendocrine, cardiovascular, metabolic, and immune system function. Bias-corrected and accelerated bootstrapped linear regression models were used to examine associations adjusting for age, income, parenthood, and other situations in which discrimination had been experienced.Results Indigenous university students who experienced racially-motivated housing discrimination in the past year (16.8% of the sample) had an average AL score of approximately 4, which was almost double that of their peers who had not. In an adjusted model. racially-motivated housing discrimination was associated with a-1.5 point increase in AL score. This model explained 35% of the adjusted variance in AL score, of which racially-motivated housing discrimination explained 24% ( R 2 Change = 0.24, F Change = 32.52, Sig. F Change p <0.001).Conclusions Indigenous adults who experienced racially-motivated housing discrimination in the past year had early and more pronounced wear and tear on neuroendocrine, cardiovascular, metabolic, and immune system functioning in young and middle adulthood than Indigenous peers who did not. These findings combine with others to highlight the need for increased efforts to prevent racially-motivated housing discrimination in urban centres.
Sampling methods affect nematode-trapping fungi biodiversity patterns across an elevational gradient.
Authors: Wei Deng , Jia-Liang Wang , Scott Matthew B. , Yi-Hao Fang , Shuo-Ran Liu , Xiao-Yan Yang , Wen Xiao 
Published: November 2019

Abstract
Background Understanding the patterns of species richness across elevational gradients is a key concept for contemporary research in ecology and evolution, and critical to understanding large-scale trends in biodiversity, global change and conservation. However, patterns of elevational species richness between taxonomic groups, regions and latitudes are inconsistent, so that the various, sometimes conflicting hypotheses exist. Several scholars have pointed out that research on elevational distribution patterns is often biased by the sampling design employed. To test this hypothesis, we analyzed species richness of nematode-trapping fungi (NTF) across an elevation gradient at two mountainous sites in western Yunnan Province, P.R. China. We tested for potential differences in the results when using different sampling designs.Results A total of 3 genera, 17 species, 222 strains of NTF were isolated and identified from Gaoligongshan and Cangshan. Species accumulation curves for both sites and sampling modes had acceptable leveling, demonstrating sufficient sampling effort. At Gaoligongshan, the elevation distribution patterns of NTF were different under two sampling patterns. When reducing the analyzed altitude range in Gaoligongshan, the elevation distribution pattern of the NTF changed. A similar elevation distribution pattern was observed in Cangshan when testing the same altitude range. In general, when treating the same dataset using different sampling designs, the resulting distribution patterns of species richness and occurrence frequencies were clearly different. Moreover, after removal of the samples located within lower-altitude zones affected by anthropogenic interferences, the distribution pattern of NTF in the two sites tended to become uniform.Conclusion The sampling design, and in particular the elevation interval between plots, has a significant effect on the assessment of species distribution in mountainous regions. Other factors such as human activities and the multi-dimensionality of biodiversity also contribute to result biases. It is recommended that future studies on the elevational gradients of species richness consider with care sampling design using stratified approaches according to the most relevant factors.
Prevalence and genotyping of Toxoplasma gondii in stray cats in Mashhad area, Iran.
Authors: Khodaverdi Majid , Razmi Gholamreza 
Published: November 2019

Abstract
Background: Cats as a definitive host have an important role in the epidemiology of toxoplasmosis in humans and animals. The aim of the study was to determine the frequency of Toxoplasma gondii infection and isolate and identify the genotypes of T. gondii in stray cats in Mashhad suburb. Methods: From April 2016 to August 2017, 175 fecal samples from stray cats and 31 brain samples from cats killed in driving accidents were collected. The fecal samples were examined by fecal flotation technique and T. gondii -specific PCR. The brain samples were investigated by T. gondii -specific PCR and consequently examined by mice bioassay. The DNA of T. gondii isolated was genotyped using SAG1, SAG2, SAG3, BTUB and GRA6 as PCR-restriction fragment length polymorphism (PCR-RFLP) markers. Results: In the present study, Toxoplasma -like oocysts were microscopically observed in 2.2% (4/175) fecal samples. The presence of Toxoplasma oocysts was confirmed in one microscopy-positive sample by PCR. In addition, T . gondii DNA was detected in 4% (7/175) microscopy-negative samples using PCR. T. gondii was isolated from one brain PCR-positive sample by mice bioassay. The isolate was avirulent and many T. gondii cysts were observed in mice brain. The isolate was successfully genotyped by PCR-RLFP analysis .The isolated genotyped was type II. Beside, eight Toxoplasma- positive fecal samples contained insufficient DNA and only amplified at SAG-3 locus in PCR. These samples were also showed type II pattern at this locus. Conclusions: Parasitological and molecular results showed low frequency of Toxoplasma infection in the stray cats, and identified the genotype of T. gondii isolate as type II, for the first time in Mashhad area, Khorasan Razavi Province.
KnowSeq R/bioc package: Beyond the traditional RNA-seq pipeline. A breast cancer case study.
Authors: Castillo-Secilla Daniel , Galvez Juan Manuel , Ortuno Francisco Manuel , Herrera Luis Javier , Rojas Ignacio 
Published: November 2019

Abstract
The number of gene expression analyses has grown exponentially over the last years. The main triggers of this increase are the reduction in the sequencing cost per sample and the technological advances, specially in the computing scope. Those analyses generally involve a number of steps. Firstly, a raw samples alignment and a quality analysis are needed. After that, a Differentially Expressed Genes (DEGs) extraction and a subsequent gene enrichment can be performed. The development of intelligent predictive tools results essential in bioinformatics given that there exists a real need of assistance for decision-making systems towards precision medicine. Therefore, KnowSeq incorporates novel steps of feature selection and classifier design in the traditional RNA-seq pipeline. No tool exists in the research community that achieves this complete RNA-seq analysis, encapsulating all those steps in one single tool.
In order to show the functionalities provided by the general pipeline designed for the KnowSeq package, an application to a real problem is presented. Concretely, an analysis of a breast cancer set of patients collected from the controlled repository GDC portal is performed, keeping paired samples between tumour and control. As results show, KnowSeq achieves extracting more relevant biological knowledge related with breast cancer from the RNA raw data acquisition. KnowSeq is available through Bioconductor.
KnowSeq R/bioc package is born with the purpose of providing an integrative tool, containing the necessary steps to address complex RNA-seq analyses in a modular and flexible way. In this paper a breast study case is addressed with KnowSeq, obtaining outstanding results and demonstrating the validity of KnowSeq to carry out gene expression analyses.
Application of ultrasound elastography for monitoring the effects of TβR1 shRNA therapy on hepatic fibrosis in a rat model
Authors: Shi Xiangzhou , Li Jing-Hua , Min Ying-Bin , Yang Rui-Jing , He Chun-Xiang , Yang Yi-Lin 
Published: November 2019

Abstract
Background: To investigate the application of ultrasound elastography in monitoring the effects of the transforming growth factor (TGF)-β1 signaling pathway-targeted combination therapy for hepatic fibrosis. Methods: 1.Short hairpin RNA (shRNA) constructs targeted towards TβR1 were designed, synthesized, and packaged using an adeno-associated virus (AAV), and the effective target shRNA was selected based on transfection results. 2. Fifty rats were randomly allocated (n=10 per group) to the (A) control group, (B) model group, (C) 0-week therapy group, (D) 4-week therapy group, and (E) combination therapy group. At weeks 2, 4, 6, 8, 10, and 12, acoustic radiation force impulse (ARFI) elastography was used to measure the liver stiffness, inner diameter of the portal vein diameter, and blood velocity; radio frequency ultrasound imaging was used to measure the abdominal aortic elasticity parameter and pulse wave velocity (PWV) of the rats. 3. At week 12, portal vein puncture was performed to measure the portal venous pressure, and rat liver specimens were obtained for the pathological measurement of the degree of hepatic fibrosis. Conclusion: Ultrasound elastography can reflect the degree of fibrosis in moderate to severe hepatic fibrosis and the variations in the degree of fibrosis after treatment through shRNA silencing of TβR1 . Therefore, it is a potential non-invasive technique for monitoring the effects of anti-fibrosis therapy.
Thyroid stimulating hormone (TSH) is associated with general and abdominal obesity in girls during puberty
Authors: Wang Yingying , Dong Xiaolian , Fu Chaowei , Su Meifang , Jiang Feng , Xu Dongli , Li Rui , Qian Junhua , Wang Na , Chen Yue , Jiang Qingwu 
Published: November 2019

Abstract
Background: Childhood obesity is an important public health issue. Although both thyroid hormone and menarche are known to play a role in body metabolism and energy expenditure, evidence for these associations in girls around puberty was limited. This study was aimed to investigate the association of TSH with general and abdominal obesity in girls during puberty. Methods: A multi-stage cluster sampling method was used to select one junior middle school from each of 4 study areas: Minhang District in Shanghai, Haimen City in Jiangsu Province, Yuhuan City and Deqing County in Zhejiang Province. A total of 474 girls aged 11 to 14 years from 4 schools were enrolled. Information on demographic factors and puberty stage were collected, and anthropometric measurements and thyroid hormones were determined. Multivariate logistic regression models were used to assess the associations of Thyroid stimulating hormone (TSH) with the risk of obesity measured by body mess index (BMI) and waist circumference (WC). Results: Of the 474 girls, the prevalences of BMI-based general obesity and WC-based abdominal obesity were 19.8% (94/474) and 21.7% (103/474), respectively. Compared with normal weight girls, the mean serum TSH concentration was significantly higher in BMI-based general overweight or obese girls (P=0.037), but not in WC-based central overweight or obese girls (P=0.173). In the multiple logistic regression models, for girls with highest tertile of serum TSH concentration relative to those in the lowest tertile, the odds ratios were 2.63 (95% CI 1.34 to 5.14) and 2.53(95% CI 1.31 to 4.88) for overweight or obesity based on BMI and WC after adjustment for puberty stage and other covariates. Conclusions: Serum TSH concentration was positively associated with both general and abdominal obesity in school-age girls and the association was independent of puberty.
Well-being in high-risk pregnancy: an integrative review
Authors: Author) kobra mirzakhani(Former Corresponding , Ebadi Abbas , Faridhosseini Farhad , Author) Talaat Khadivzadeh(New Corresponding 
Published: November 2019

Abstract
Abstract
Background: A prerequisite to the interventions for well-being improvement in high-risk pregnancy is to make the concept clear, objective, and measurable. Despite the wealth of studies into the concept of well-being in high-risk pregnancy, there is no clear definition for it. This study aimed to explore the concept of well-being in high-risk pregnancy.
Methods: This integrative review was conducted using the Whittemore and Knafl’s approach. A literature search was done without any data limitation in dictionaries, thesauruses, encyclopedias, well-being-related textbooks, midwifery, psychology, and mental health journals, and Iranian and international databases. The most primary inclusion criterion was relevance well-being in high-risk pregnancy. The full-texts of all articles were assessed using the checklists of the Joanna Briggs Institute (JBI). Data were analyzed through the constant comparison method and were managed using the MAXQDA 10 software. Meaning units were identified and coded. The codes were grouped into subcategories and categories according to the attributes, antecedents, and consequences of well-being in high-risk pregnancy.
Results: Thirty articles were included in the review, from which 540 codes were extracted. The codes were grouped into seven main attributes, eight main antecedents, and five main consequences of well-being in HRP. Findings showed that the four dimensions of well-being in high-risk pregnancy concept were physical, mental-emotional, social, and spiritual well-being.
Conclusion: As a complex and multidimensional concept, well-being in high-risk pregnancy refers to the pregnant woman’s evaluation of her life during high-risk pregnancy. It includes physical, hedonic, and eudaimonic components. The assessment of well-being in HRP should include all these components.
Keywords: Well-being, Pregnancy, High-risk pregnancy
Genetic mapping and genomic selection for maize stalk strength
Authors: Liu Xiaogang , Hu Xiaojiao , Li Kun , Liu Zhifang , Wu Yujin , Wang Hongwu , Huang Changling 
Published: November 2019

Abstract
Background Maize is one of the most important staple crops and is widely grown throughout the world. Stalk lodging can cause enormous yield losses in maize production. However, rind penetrometer resistance (RPR), which is recognized as a reliable measurement to evaluate stalk strength, has been shown to be efficient and useful for improving stalk lodging-resistance. Linkage mapping is an acknowledged approach for exploring the genetic architecture of target traits. In addition, genomic selection (GS) using whole genome markers enhances selection efficiency for genetically complex traits. In the present study, two recombinant inbred line (RIL) populations were utilized to dissect the genetic basis of RPR, which was evaluated in seven growth stages.Results The optimal stages to measure stalk strength are the silking phase and stages after silking. A total of 66 and 45 quantitative trait loci (QTL) were identified in each RIL population. Several potential candidate genes were predicted according to the maize gene annotation database and were closely associated with the biosynthesis of cell wall components. Moreover, analysis of gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway further indicated that genes related to cell wall formation were involved in the determination of RPR. In addition, a multivariate model of genomic selection efficiently improved the prediction accuracy relative to a univariate model and a model considering RPR-relevant loci as fixed effects.Conclusions The genetic architecture of RPR is highly genetically complex. Multiple minor effect QTL are jointly involved in controlling phenotypic variation in RPR. Several pleiotropic QTL identified in multiple stages may contain reliable genes and can be used to develop functional markers for improving the selection efficiency of stalk strength. The application of genomic selection to RPR may be a promising approach to accelerate breeding process for improving stalk strength and enhancing lodging-resistance.
Investigating the satisfaction level of physicians in regards to implementing medical picture archiving and communication system (PACS)
Authors: Abbasi Reza , Jabali Monireh Sadeqi , Tadayon Hamidreza 
Published: November 2019

Abstract
Background User's satisfaction with PACS is considered as one of the important criteria for assessing success in using PACS. The objective of this study is to determine the level of satisfaction in PACS’ users and also comparing its functional features with traditional film-based systems.Methods This analytical study was conducted in 2017. Residents at three large university hospitals in Kerman city were included. We used self-administered questionnaire that was consisted of three parts include: demographic information, individuals' satisfaction, comparing features of the two digital and traditional imaging systems. Validity of this questionnaire was approved by specialists and its reliability was obtained as 86%. Data analysis was done with using descriptive statistics and after checking the normality of data, data compared with the spearman, the Mann Whitney U and the Kruskal-Wallis statistical tests.Results The mean of the participants' ages 31.4 (± 4.4) years old and approximately 59% of the participants were females. Mean of overall physicians’ satisfaction with PACS' score has no significant relationship (P>0.05) with the variables of age, experience in using PACS, type of specialty, level of interpretation of images using PACS, however it did show a significant relationship with their computer skills (P<0.05).Conclusions The mean for physicians’ satisfaction with PACS was at a moderate to high level, yet there are still problems in successfully implementing these systems and establishing interoperability between them. PACS has not fully met all the demands of physicians and has not achieved its predetermined objectives such as all-access from different locations.