bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ experiences of study-related exhaustion, regulation of learning, peer learning and peer support during university studies
Authors: Räisänen Milla , Postareff Liisa , Lindblom-Ylänne Sari 
Published: November 2020

AbstractThe present mixed-method longitudinal study examines students’ experiences of study-related exhaustion, regulation of learning, peer learning and peer support during university studies. At the first measurement point, 188 first-year students completed the questionnaire. At the second measurement point, 91 of the 188 students participated in the follow-up study at their fourth study year and completed the same questionnaire again. Of these, twelve students were interviewed. The results showed that experienced study-related exhaustion and self-regulation of content increased during studies. However, the results also showed a large individual variation in experienced study-related exhaustion. The students whose exhaustion decreased described experiences of peer support that helped them to develop their self-regulation skills. Students whose study-related exhaustion remained low evaluated their self-regulation skills as good. They experienced that they did not need other students’ support in the regulation of learning. The students whose study-related exhaustion increased or remained high described more problems in self-regulation. Most students relied on peer support because of self-regulation problems. However, not all students used other students’ support despite of problems in studying. It can be concluded that regulation skills have a key role in experienced study-related exhaustion during studies.
Fluorescence analysis allows to predict the oxidative capacity of humic quinones in dissolved organic matter: implication for pollutant degradation
Authors: Palma Davide , Parlanti Edith , Sourzac Mahaut , Voldoire Olivier , Beauger Aude , Sleiman Mohamad , Richard Claire 
Published: November 2020

AbstractDissolved organic matter (DOM) controls the degradation and sequestration of aquatic pollutants and, in turn, water quality. In particular, pollutant degradation is performed by oxidant species that are generated by exposure of DOM to solar light, yet, since DOM is a very complex mixture of poorly known substances, the relationships between potential oxidant precursors in DOM and their oxydative capacity is poorly known. Here, we hypothesized that production of oxidant species could be predicted using fluorescence analysis. We analysed water samples from an alluvial plain by fluorescence spectroscopy; the three-dimensional spectra were then decomposed into seven individual components using a multi-way algorithm. Components include a protein-like fluorophore, e.g. tryptophan-like and tyrosine-like, three humic fluorophores, 2-naphthoxyacetic acid, and a by-product. We compared component levels with the ability of water samples to generate reactive species under solar light. The results show a strong correlation between reactive species production and the intensity of two humic-like fluorophores assigned to reduced quinones. Monitoring these fluorophores should thus allow to predict the ability of DOM degradation of pollutants in surface waters.
Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray
Authors: Parks R. M. , Albanghali M. A. , Syed B. M. , Green A. R. , Ellis I. O. , Cheung K-L. 
Published: November 2020

Abstract
Purpose
Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study uses a unique method for construction of core needle biopsy (CNB) tissue microarray (TMA), to correlate expression of a panel of 17 biomarkers with clinical outcome, in patients receiving PET.

Methods
Over 37 years (1973–2010), 1758 older (≥ 70 years) women with operable primary breast cancer were managed in a single institution. Of these, 693 had sufficient good-quality CNB to construct TMA, of which 334 had ER-positive tumours treated by PET with a minimum of 6-month follow-up. A panel of biomarkers was measured by immunohistochemistry (ER, PgR, HER2, Ki-67, p53, CK5/6, CK 7/8, EGFR, BCL-2, MUC1, VEGF, LKB1, BRCA1, HER3, HER4, PTEN and AIB1). Expression of each biomarker was dichotomised into ‘low’ or ‘high’ based on breast cancer-specific survival (BCSS).

Results
From the panel of biomarkers, multivariate analysis showed:

High ER (p = 0.003) and PgR (p = 0.002) were associated with clinical benefit of PET at 6 months, as opposed to progressive disease.

High ER (p = 0.0023), PgR (p < 0.001) and BCL-2 (p = 0.043) and low LKB1 (p = 0.022) were associated with longer time to progression.

High PgR (p < 0.001) and low MUC1 (p = 0.021) were associated with better BCSS.

Expression of other biomarkers did not show any significant correlation.

Conclusions
In addition to ER and PgR; MUC1, BCL-2 and LKB1 are important in determining the outcome of PET in this cohort.
SMILE: a feature-based temporal abstraction framework for event-interval sequence classification
Authors: Rebane Jonathan , Karlsson Isak , Bornemann Leon , Papapetrou Panagiotis 
Published: November 2020

AbstractIn this paper, we study the problem of classification of sequences of temporal intervals. Our main contribution is a novel framework, which we call , for extracting relevant features from interval sequences to construct classifiers. introduces the notion of utilizing random temporal abstraction features, we define as , as a means to capture information pertaining to class-discriminatory events which occur across the span of complete interval sequences. Our empirical evaluation is applied to a wide array of benchmark data sets and fourteen novel datasets for adverse drug event detection. We demonstrate how the introduction of simple sequential features, followed by progressively more complex features each improve classification performance. Importantly, this investigation demonstrates that significantly improves AUC performance over the current state-of-the-art. The investigation also reveals that the selection of underlying classification algorithm is important to achieve superior predictive performance, and how the number of features influences the performance of our framework.
Three polymorphisms of renin-angiotensin system and preeclampsia risk
Authors: Wang Chen , Zhou Xiao , Liu Huai , Huang Shuhui 
Published: November 2020

Abstract
Purpose
Some data suggest an association between the single nucleotide polymorphisms AGT T704C, ACE I/D, and AT1R A1166C and preeclampsia, but overall, the data are conflicting; the aim of our study was to discover a more stable and reliable association between these polymorphisms and PE risk.

Methods
A comprehensive literature search for this meta-analysis was conducted. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the strength, and heterogeneity test was conducted. Trial sequential analysis was also performed.

Results
A total of forty studies were finally included in our meta-analysis. The AGT T704C polymorphism was associated with PE risk in three genetic models (dominant OR = 1.33, 95%CI = 1.12–1.59; heterozygote OR = 1.26, 95%CI = 1.05–1.52; homozygote OR = 1.44, 95%CI = 1.14–1.83). No heterogeneity was observed in the three genetic models for the ACE I/D polymorphism. For subgroup analysis by geography, no significant association was detected. Significant associations were observed in mixed race, early-onset, late-onset, and more than 200 subgroups for the AT1R A1166C polymorphism; however, only one study was analyzed in these subgroups.

Conclusions
Our results indicated the AGT T704C and ACE I/D polymorphisms were associated with an increased risk of PE. Increased risks were also observed for the two polymorphisms in subgroups including Asians, Europeans, Caucasoid, and Mongoloid. Moreover, an increased PE risk with the ACE I/D polymorphism in the severe PE population was also detected. Regarding the AT1R A1166C polymorphism, weak associations were observed, but further studies are required.
Complete loss of case and gender within two generations: evidence from Stamford Hill Hasidic Yiddish
Authors: Belk Zoë , Kahn Lily , Szendrői Kriszta Eszter 
Published: November 2020

AbstractYiddish was the everyday language spoken by most Central and East European Jews during the last millennium. As a result of the extreme loss of speakers during the Holocaust, subsequent geographic dispersal, and lack of institutional support, Yiddish is now an endangered language. Yet it continues to be a native and daily language for Haredi (strictly Orthodox) Jews, who live in close-knit communities worldwide. We have conducted the first study of the linguistic characteristics of the Yiddish spoken in the community in London’s Stamford Hill. While Krogh (in: Aptroot, Aptroot et al. (eds.) Leket: Yiddish studies today, Düsseldorf University Press, Düsseldorf, pp 483–506, 2012), Assouline (in: Aptroot, Hansen (eds.) Yiddish language structures, De Gruyter Mouton, Berlin, pp 39–62, 2014), and Sadock and Masor (J Jew Lang 6(1):89–110, 2018), investigating other Hasidic Yiddish-speaking communities, observe what they describe as morphological syncretism, in this paper we defend the claim that present-day Stamford Hill Hasidic Yiddish lacks morphological case and gender completely. We demonstrate that loss of morphological case and gender is the result of substantial language change over the course of two generations: while the case and gender system of the spoken medium was already beginning to undergo morphological syncretism and show some variation prior to World War II, case and gender distinctions were clearly present in the mental grammar of both Hasidic and non-Hasidic speakers of the relevant Yiddish dialects at that stage. We conclude the paper by identifying some of the language-internal, sociolinguistic and historical factors that have contributed to such rapid and pervasive language change, and compare the developments in Stamford Hill Hasidic Yiddish to those of minority German dialects in North America.
Pathological angiogenesis and inflammation in tissues
Authors: Jeong Ji-Hak , Ojha Uttam , Lee You Mie 
Published: November 2020

AbstractThe role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–organ interaction is a key mechanism and a concept that enables an understanding of all biological phenomena and normal physiology that is essential for human survival under pathological conditions. Recently, vascular endothelial cells have been classified as a type of innate immune cells that are dependent on the pathological situations. Moreover, inflammatory cytokines and signaling regulators activated upon exposure to infection or various stresses play crucial roles in the pathological function of parenchymal cells, peripheral immune cells, stromal cells, and cancer cells in tissues. Therefore, vascular–organ interactions as a vascular microenvironment or tissue microenvironment under physiological and pathological conditions are gaining popularity as an interesting research topic. Here, we review vascular contribution as a major factor in microenvironment homeostasis in the pathogenesis of normal as well as cancerous tissues. Furthermore, we suggest that the normalization strategy of pathological angiogenesis could be a promising therapeutic target for various diseases, including cancer.
Thrust Shear Sense and Shear Zone Fabrics in the Higher Himalaya, Siyom Valley, Eastern Arunachal Himalaya, India
Authors: Goswami Tapos Kumar , Baruah Sukumar , Mahanta Bashab Nandan , Kalita Pranjit , Bora Polash 
Published: November 2020

Abstract
The Higher Himalayan Crystallines (HHC) in the Siyom river section of eastern Arunachal Himalaya, display top-to- ESE compressional ductile shear from Pene to Menchuka. In this part of the Himalayan Metamorphic Belt (HMB), the base of the Main Central Thrust (MCT) is the southern boundary of the ductile shear fabrics in HHC. Across the MCT, a significant break in the grade of metamorphism is observed between the HHC and the Lesser Himalayan Sequences (LHS). The ductile shear fabrics documented in the HHC are primary S-C and S-C′ fabrics, asymmetric folds, porphyroclasts and porphyrobalsts, brittle- ductile structures and asymmetric boudins. Three phases of folding representing three deformation episodes (D1-D3) in HHC are recorded in the area. The rocks of the HHC in Siyom valley are completely transposed by the D2 deformation into NNW dipping C- plane. Ductile shear represented by grain scale structures include sigmoidal foliation, rotation of the inclusion trails in garnet porphyroblasts, asymmetric folds with consistent top-to-ESE sense of shear. The ductile to brittle-ductile shear fabrics in the area indicate that the thrust sense of shear in the HHC is consistent without any shear sense reversal from Pene to Menchuka. These compressional shear fabrics provide invaluable field evidences for constraining the evolution of this part of the Higher Himalaya.
What Is the Impact of Informal Entrepreneurship on Venture Capital Flows?
Authors: Santos Eunice , Fernandes Cristina I. , Ferreira João J. , Lobo Carla Azevedo 
Published: November 2020

AbstractThere has been a diverse range of research on the factors enabling informal entrepreneurship as well as the means to avoid or to eradicate its incidence. Several researchers argued that venture capital and financial flows, in general, contribute to economic growth and development. There have also been observations of how the investor level of trust in institutions facilitates investment decisions. This trust comes into play at the level of informal entrepreneurship and the ability of governments to control this type of entrepreneurship. Given that a great deal of research on this subject focuses its analysis on developing countries, we have chosen to investigate the reality of European countries precisely because of the scarcity of studies on the effect of informal entrepreneurship in this context. Our research aims to assess how informal entrepreneurship effects on venture capital flows. We use aggregated data at country level collected from a variety of sources, including the World Bank, Organization for Cooperation and Development and World Economic Forum, between 2006 and 2015 and 23 countries in Europe, corresponding to 230 observations (panel no. balanced). Through econometric estimation, which took place according to methodologies based on multiple regression models for panel data, the results demonstrate how informal entrepreneurship has a negative moderating effect between GDP and venture cUKapital flows. We intend to contribute to a better understanding of the effect of informal entrepreneurship on the flows of venture capital.
Religiosity and Trust: Evidence from the United States
Authors: Valente Rubia R. , Okulicz-Kozaryn Adam 
Published: November 2020

Background Trust is one of the key driving forces behind human action and an important factor in shaping human interaction. Trust can improve economic growth, political and civic involvement, democratic stability, and subjective well-being. Yet, trust has been in decline for the last 60 years in the U.S. Purpose This article tests the effect of several indicators of religiosity, including an index for both social and individual religiosity, on trust. Common religious doctrine instructs followers to place their trust solely in God, and can therefore be interpreted as a determinant of generalized trust. Thus, the purpose of this paper is to find out whether religious people are more likely to be distrustful of others and whether they are more likely to be misanthropic. Methods We use the US General Social Survey (GSS, 1972–2018, [Formula: see text]), a large, recurring, and nationally-representative sample of U.S. adults. Using the GSS, we investigate the relationship between religiosity and trust (interpersonal and generalized) in a well-controlled model using OLS regressions. We examine both the effects of social religiosity (e.g. church attendance, membership at religious organization), and individual religiosity (e.g. belief in God, feeling of closeness to God, prayer), on trust and on misanthropy. Several additional robustness tests were conducted. Results The findings demonstrate that while social religiosity or belonging (services attendance, church membership) predicts more trust, individual religiosity or believing (prayer, closeness and belief in God) predicts lower trust. Likewise, social religiosity lowers misanthropy, while individual religiosity promotes it. Furthermore, we show that it is important to consider individual and social religiosity simultaneously because they correlate and have opposite effects–this is an intriguing and not entirely obvious finding as most people would expect that religiosity in general, has a positive effect on trust. Conclusions and Implications Our results indicate that religiosity is a substantial determinant of social trust and of misanthropy. The divergent results based on whether religiosity is social or individual in character is a new conceptual approach towards religiosity not previously undertaken in the literature. Ingroup favoritism and outgroup derogation theory explains our findings—connecting with God disrupts connection with humans.
Benefits and Feasibility of Using Videos to Assess Medical School Applicants’ Empathetic Abilities in Multiple Mini Interviews
Authors: Kim Kyong-Jee , Lee Nam Young , Kwon Bum Sun 
Published: November 2020

Abstract
Purpose
We sought to evaluate the feasibility and benefits of using video-based scenarios in Multiple Mini Interviews (MMIs) to assess candidate’s empathic abilities by investigating candidate perceptions and the acceptability, fairness, reliability, and validity of the test.

Methods
The study sample was candidates for admission interviews held in the MMI format at a medical school in South Korea. In this six-station MMI, one station included a 2-min video clip of a patient-doctor communication scenario to assess candidate emphatic abilities, whereas paper-based scenarios were used in the other stations. Candidate’s perceptions and acceptability of using the video-based scenario in the empathy station were examined using a 41-item post-MMI questionnaire. Fairness of the test was assessed by means of differences in candidate perceptions and performance across different demographics or backgrounds. Construct validity was assessed by examining the relationship of candidate performances in the empathy station with those in other stations. The G-coefficient was analyzed to estimate the reliability of the test.

Results
Eighty-two questionnaires were returned, a 97.6% response rate. Candidates showed overall positive perceptions of the video-based scenario and they found it authentic and interesting. The test was fair as there were no differences in candidates’ perceptions of the patient-doctor relationship presented in the video clip and neither in their performance nor in their perceived difficulty of the station across demographics or backgrounds. Construct validity was established as candidate performance in the empathy station was not associated with that of any other stations. The G-coefficient was 0.74.

Conclusions
The present study demonstrates that the video-based scenario is a feasible tool to assess candidate’s empathy in the MMI.
A new method for the quantification of adsorbed styrene acrylate copolymer particles on cementitious surfaces: a critical comparative study
Authors: Schirmer Ulrike , Osburg Andrea 
Published: November 2020

AbstractThe amount of adsorbed styrene acrylate copolymer (SA) particles on cementitious surfaces at the early stage of hydration was quantitatively determined using three different methodological approaches: the depletion method, the visible spectrophotometry (VIS) and the thermo-gravimetry coupled with mass spectrometry (TG–MS). Considering the advantages and disadvantages of each method, including the respectively required sample preparation, the results for four polymer-modified cement pastes, varying in polymer content and cement fineness, were evaluated.To some extent, significant discrepancies in the adsorption degrees were observed. There is a tendency that significantly lower amounts of adsorbed polymers were identified using TG-MS compared to values determined with the depletion method. Spectrophotometrically generated values were ​​lying in between these extremes. This tendency was found for three of the four cement pastes examined and is originated in sample preparation and methodical limitations.The main influencing factor is the falsification of the polymer concentration in the liquid phase during centrifugation. Interactions in the interface between sediment and supernatant are the cause. The newly developed method, using TG–MS for the quantification of SA particles, proved to be suitable for dealing with these revealed issues. Here, instead of the fluid phase, the sediment is examined with regard to the polymer content, on which the influence of centrifugation is considerably lower.
Design issues and performance analysis of CCM boost converters with RHP zero mitigation via inductor current sensing
Authors: Leoncini Mauro , Levantino Salvatore , Ghioni Massimo 
Published: November 2020

AbstractThe right-half plane (RHP) zero in the control to output voltage transfer function of a boost converter operating in the continuous conduction mode limits the loop bandwidth. By injecting a scaled version of the inductor current into the loop, it is possible to shift the zero from the right-half plane to the left-half plane, which leads to increased stability of the control loop. This solution generates a static voltage error at the output of the converter (tracking error), which may be unacceptable in practical applications. A few strategies to mitigate or correct this tracking error have been suggested. However, they have never been fully assessed. This paper thoroughly investigates the impact of the RHP zero mitigation technique on the dynamic performance of a boost converter, and identifies the complex trade-off between the system stability, transient response, and tracking error correction capability. Based on these findings, design guidelines are provided to help maximize system performance. A representative case study is considered to highlight the performance benefits and simulation results are presented to validate the analysis.
Mesenchymale Stammzellen als neue Therapie bei Morbus-Crohn-Patienten mit Fisteln
Authors: Cabalzar-Wondberg Daniela , Turina Matthias 
Published: November 2020

ZusammenfassungDie Behandlung komplexer Morbus-Crohn-assoziierter perianaler Fisteln erfordert meist ein interdisziplinäres Vorgehen. Der medikamentösen Therapie wird zur initialen Behandlung sowie zum Remissionserhalt eine essenzielle Rolle zuteil. Bei einem unzureichenden Ansprechen oder bei Therapieversagen ist bei symptomatischen Fisteln ein chirurgisches Vorgehen der nächste Schritt. Aufgrund der Komplexität der Grunderkrankung und der krankheitsassoziierten Anatomie führt die operative Behandlung jedoch häufig zu Fistelrezidiven. Die Behandlung mit mesenchymalen Stammzellen etabliert sich als eine neue innovative Therapieoption bei Patienten mit perianalen Crohn-assoziierten komplexen Fisteln, die auf eine konventionelle Therapie oder auf Biologika nicht oder nur unzureichend angesprochen haben. Die aus dem Fettgewebe eines Spenders gewonnenen Stammzellen werden lokal injiziert und weisen immunmodulatorische und antiinflammatorische Eigenschaften auf, was zu einer besseren Fistelheilung führen soll. Diese ambulant durchführbare Operation stellt zudem eine sphinkterschonende Behandlungsmethode ohne größere Wundfläche dar. In der Literatur finden sich zum jetzigen Zeitpunkt vielversprechende Resultate, die bislang auch im eigenen Patientengut bestätigt werden können.