bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humeurs sénescentes : la question narcissique dans le vieillissement
Authors: Rexand-Galais Franck 
Published: December 2019

Développée en premier par Balier (1976), la théorie du vieillissement narcissique constitue une clef de compréhension incontournable des enjeux psychopathologiques du vieillissement et de la question de l’humeur sénescente en particulier. Alors que l’abord contemporain (American Psychiatric Association, 2013) produit une mise en forme catégorielle des troubles de l’humeur toujours plus affinée qui est loin de correspondre aux spécificités de la sénescence (Batelaan et coll., 2012 ; Calvet et Clément, 2014), la théorie narcissique du vieillissement permet de restituer une cohérence explicative aux troubles du vieillissement en rendant compte de leurs liens. À travers sa prise en compte des larges conséquences des atteintes subies par le narcissisme au cours de la vieillesse, elle donne au narcissisme un rôle central dans le fonctionnement psychique sénescent. La reprise de la pensée de Balier à la lumière de ses sources (Kestemberg et Kestemberg, 1966) et des éclairages les plus contemporains (Beatson et coll., 2016) permet d’approfondir la théorie en la prolongeant et d’isoler une « désorganisation limite sénescente partagée » et ses différents destins. La prise en compte clinique de ce fonctionnement limite au cours du vieillissement et de son devenir est d’une importance centrale dans la prise en charge psychothérapeutique des troubles du vieillissement.
Häufigkeit eines Risikos für Mangelernährung bei Patienten in onkologischen Schwerpunktpraxen – eine Querschnittserhebung
Authors: Hauner Hans , Kocsis Alexandra , Jaeckel Benjamin , Martignoni Marc , Hauner Dagmar , Holzapfel Christina 
Published: December 2019

Zusammenfassung
Hintergrund Daten zum Ernährungsstatus von Patienten mit Tumorerkrankungen in ambulanten Einrichtungen fehlen in Deutschland. Die durchgeführte Querschnittserhebung bei Patienten mit Tumorerkrankungen hatte daher das Ziel, die Häufigkeit eines Risikos für Mangelernährung bei Tumorpatienten in onkologischen Schwerpunktpraxen zu ermitteln.
Methode Patienten mit Tumorerkrankungen wurden mittels eines standardisierten Fragebogens konsekutiv in 17 onkologischen Schwerpunktpraxen in Südbayern zwischen Juni 2017 und Mai 2018 befragt. Neben Fragen zum Gesundheitszustand und zur Ernährung wurden die validierten Screening-Fragebögen Malnutrition Universal Screening Tool (MUST) und Nutritional Risk Screening Tool-2002 (NRS-2002) zur Erfassung des Risikos für Mangelernährung (primärer Endpunkt) eingesetzt. Die statistische Auswertung erfolgte deskriptiv.
Ergebnisse Insgesamt wurden Datensätze von 765 Patienten (60,9 % Frauen) ausgewertet. Die Teilnehmer waren im Mittel 63,1 ± 13,1 Jahre alt, der durchschnittliche Body-Mass-Index (BMI) betrug 25,2 ± 5,1 kg/m2. Bei Anwendung des MUST-Fragebogens hatten 15,4 % der Teilnehmer ein mittleres und 19,5 % ein hohes Risiko für eine Mangelernährung. Darunter wiesen am häufigsten Patienten mit Tumoren des Verdauungssystems ein Risiko für eine Mangelernährung auf (46,6 %). Die Kriterien für ein Mangelernährungsrisiko nach dem NRS-2002-Score (≥ 3 Punkte) erfüllten hingegen 29,1 % der befragten Patienten. Weniger als ein Drittel der Tumorpatienten hatte nach Diagnosestellung eine Ernährungsberatung erhalten (29,9 %).
Schlussfolgerung Etwa jeder dritte Patient mit einer Tumorerkrankung in ambulanter Betreuung weist ein erhöhtes Risiko für eine Mangelernährung auf. Die Ergebnisse dieser Erhebung unterstreichen die Notwendigkeit für ein systematisches Screening auf Mangelernährung und ein leitliniengerechtes Ernährungsmanagement von Tumorpatienten in der ambulanten Versorgung.
Perspektive einer PrEP-Nutzerin auf die PrEP
Authors: Sweers Holger 
Published: December 2019

ZusammenfassungMiriam (Pseudonym) ist zum Zeitpunkt des Interviews im Herbst 2018 35 Jahre alt. Sie lebt seit mehr als zehn Jahren in Berlin, wo sie auch studiert hat. Aktuell arbeitet sie als Marketingexpertin. Miriam führt ein aktives, selbstbestimmtes Sexualleben und greift aus guten Gründen zur HIV-PrEP, wie sie im Interview mit Holger Sweers erklärt.
How to identify patients who are less likely to have metachronous neoplasms after a colon cancer: a predictive model
Authors: Frazzoni Leonardo , Laterza Liboria , Mussetto Alessandro , Zagari Rocco Maurizio , Trovato Cristina , De Bellis Mario , Paggi Silvia , Piccirelli Stefania , Ricciardiello Luigi , Cesaro Paola , Spada Cristiano , Dal Piaz Giulia , La Marca Marina , Fabbian Fabio , Petrella Laura , Smania Veronica , Marone Pietro , Tatangelo Fabiana , Bazzoli Franco , Radaelli Franco , Repici Alessandro , Hassan Cesare , Scagliarini Michele , Fuccio Lorenzo 
Published: December 2019

Abstract
Background Patients with prior colon cancer have increased risk of metachronous colorectal neoplasms; therefore, endoscopic surveillance is indicated. Current recommendations are not risk-stratified. We investigated predictive factors for colorectal neoplasms to build a model to spare colonoscopies for low-risk patients.
Methods This was a multicenter, retrospective study including patients who underwent surgery for colon cancer in 2001 – 2008 (derivation cohort) and 2009 – 2013 (validation cohort). A predictive model for neoplasm occurrence at second surveillance colonoscopy was developed and validated.
Results 421 and 203 patients were included in derivation and validation cohort, respectively. At second surveillance colonoscopy, 112 (26.6 %) and 55 (27.1 %) patients had metachronous neoplasms in derivation and validation groups; three cancers were detected in the latter. History of left-sided colon cancer (OR 1.64, 95 %CI 1.02 – 2.64), ≥ 1 advanced adenoma at index colonoscopy (OR 1.90, 95 %CI 1.05 – 3.43), and ≥ 1 adenoma at first surveillance colonoscopy (OR 2.06, 95 %CI 1.29 – 3.27) were independently predictive of metachronous colorectal neoplasms at second surveillance colonoscopy. For patients without such risk factors, diagnostic accuracy parameters were: 89.3 % (95 %CI 82.0 %-94.3 %) and 78.2 % (95 %CI 65.0 %-88.2 %) sensitivity, and 28.5 % (95 %CI 23.5 %-33.9 %) and 33.8 % (95 %CI 26.2 %-42.0 %) specificity in derivation and validation group, respectively. No cancer would be missed.
Conclusions Patients with prior left-sided colon cancer or ≥ 1 advanced adenoma at index colonoscopy or ≥ 1 adenoma at first surveillance colonoscopy had a significantly higher risk of neoplasms at second surveillance colonoscopy; patients without such factors had much lower risk and could safely skip the second surveillance colonoscopy. A prospective, multicenter validation study is needed.
Psychische Komorbidität bei der juvenilen idiopathischen Arthritis
Authors: Sengler Claudia , Niewerth Martina , Holl Reinhard W. , Kilian Reinhold , Meissner Thomas , Staab Doris , Warschburger Petra , Baumeister Harald , Minden Kirsten 
Published: December 2019

ZUSAMMENFASSUNGPsychische Erkrankungen wie Depression und Angst beginnen häufig im Jugend- und jungen Erwachsenenalter. Heranwachsende mit einer chronischen rheumatischen Erkrankung haben hierfür ein besonderes Risiko. In Untersuchungen zur psychischen Gesundheit gaben in der Regel über 10 % der Jugendlichen mit juveniler idiopathischer Arthritis (JIA) depressive Symptome an. Die frühzeitige Erkennung von psychischen Belastungen ist notwendig, um Betroffenen rechtzeitig adäquate Unterstützung anbieten zu können. Geschieht das nicht, werden Möglichkeiten, die Langzeitprognose und Lebensqualität der Betroffenen zu verbessern, verpasst. Psychische Störungen werden in der klinischen Praxis oft nur am Rande berücksichtigt. Wie groß das Problem unter den bundesweit kinder- und jugendrheumatologisch betreuten Patienten mit JIA ist, wird in diesem Jahr im Rahmen des interdisziplinären Forschungsverbundes COACH untersucht.
Limited diagnostic accuracy and clinical impact of single-operator peroral cholangioscopy for indeterminate biliary strictures
Authors: de Vries Adriaan B. , van der Heide Frans , ter Steege Rinze W. F. , Koornstra Jan Jacob , Buddingh Karel T. , Gouw Annette S. H. , Weersma Rinse K. 
Published: December 2019

Abstract
Background Single-operator peroral cholangioscopy (sPOCS) is considered a valuable diagnostic modality for indeterminate biliary strictures. Nevertheless, studies show large variation in its characteristics and measures of diagnostic accuracy. Our aim was to estimate the diagnostic accuracy of sPOCS visual assessment and targeted biopsies for indeterminate biliary strictures. Additional aims were: estimation of the clinical impact of sPOCS and comparison of diagnostic accuracy with brush cytology.
Methods A retrospective single-center study of adult patients who underwent sPOCS for indeterminate biliary strictures was performed. Diagnostic accuracy was defined as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The clinical impact of sPOCS was assessed by review of medical records, and classified according to its influence on patient management.
Results 80 patients were included, with 40 % having primary sclerosing cholangitis (PSC). Prior ERCP was performed in 88 %, with removal of a biliary stent prior to sPOCS in 55 %. The sensitivity, specificity, PPV, and NPV for sPOCS visual impression and targeted biopsies were 64 %, 62 %, 41 %, and 84 %, and 15 %, 65 %, 75 %, and 69 %, respectively. The clinical impact of sPOCS was limited; outcome changed management in 17 % of patients. Sequential brush cytology sensitivity, specificity, PPV, and NPV were 47 %, 95 %, 80 %, and 83 %.
Conclusions The diagnostic accuracy of sPOCS for indeterminate biliary strictures was found to be inferior to brush cytology, with a low impact on patient management. These findings are obtained from a select patient population with a high prevalence of PSC and plastic stents in situ prior to sPOCS.
Variables Correlated with Physical Activity and Conformance to
Physical Activity Guidelines in Healthy Children and Children with Down
Syndrome
Authors: Alhusaini Adel A. , Ali Al-Walah Misfer , Melam Ganeswara Rao , Buragadda Syamala 
Published: December 2019

Zusammenfassung
Ziel Kinder mit Down-Syndrom zeigen körperliche und geistige
Entwicklungsverzögerungen. Aus diesem Grund können sie
möglicherweise die Empfehlungen für Bewegung nicht
erfüllen. Hauptziel dieser Studie war es, das Maß der
körperlichen Aktivität und die Gehleistung von Kindern mit
Down-Syndrom zu beurteilen.
Material und Methoden Querschnittsstudie. Es wurden Kinder mit
Down-Syndrom und gesunde Kinder im Alter von 8 bis 12 Jahren untersucht. Die
körperliche Aktivität wurde über 7 Tage mittels
Pedometer gemessen und die Gehfähigkeit wurde mittels 6-Minuten Gehtest
(6MWT) bewertet.
Ergebnisse Kinder mit Down-Syndrom sind körperlich weniger aktiv
als gesunde Kinder. Der Test der durchschnittlichen Gehfähigkeit ergab
in allen Altersgruppen signifikante Unterschiede zwischen gesunden Kindern und
Kindern mit Down-Syndrom. Es bestand ein enger Zusammenhang zwischen der
täglichen Schrittzählung und der Gehfähigkeit.
Schlussfolgerung In unserer Studie konnten wir feststellen, dass Kinder
mit Down-Syndrom einen höheren BMI haben, weniger körperlich
aktiv sind und im Vergleich zu normal entwickelten Kindern eine geringere
Gehfähigkeit aufweisen.
Perspektive eines ehemaligen PrEP-Nutzers auf die PrEP
Authors: Döring Nicola 
Published: December 2019

ZusammenfassungSteve Spencer war einer der ersten HIV-PrEP-Nutzer in Australien und Gründungsmitglied von PAN (PrEP Access Now), einer Non-Profit-Organisation, die sich für niedrigschwelligen Zugang zu PrEP in Australien einsetzt. Trotz PrEP-Einnahme hat er sich 2018 mit HIV infiziert. Denn die PrEP bietet zwar einen sehr hohen, aber eben keinen perfekten Schutz. Wovor er jetzt Angst hat und warum er sich immer noch für die PrEP stark macht, fasst Nicola Döring anhand seiner Pressebeiträge zusammen.
Aryl-Decarboxylation Reactions Catalyzed by Palladium: Scope and Mechanism
Authors: Daley Ryan A. , Topczewski Joseph J. 
Published: December 2019

Palladium-catalyzed cross-couplings and related reactions have enabled many transformations essential to the synthesis of pharmaceuticals, agrochemicals, and organic materials. A related family of reactions that have received less attention are decarboxylative functionalization reactions. These reactions replace the preformed organometallic precursor (e.g., boronic acid or organostannane) with inexpensive and readily available carboxylic acids for many palladium-catalyzed reactions. This review focuses on catalyzed reactions where the elementary decarboxylation step is thought to occur at a palladium center. This review does not include decarboxylative reactions where decarboxylation is thought to be facilitated by a second metal (copper or silver) and is specifically limited to (hetero)arenecarboxylic acids. This review includes a discussion of oxidative Heck reactions, protodecarboxylation reactions, and cross-coupling reactions among others.1	Introduction2	Oxidative Heck Reactions3	Protodecarboxylation Reactions4	Cross-Coupling Reactions5	Other Reactions6	Conclusion
Artroplastia reversa de ombro: Resultados funcionais na artropatia do manguito
Authors: Nascimento Alexandre T. , Claudio Gustavo K. , Rocha Pedro B. 
Published: December 2019

Resumo
Objetivo Avaliar os resultados funcionais dos pacientes submetidos a artroplastia reversa de ombro, para tratamento da artropatia do manguito refratária a tratamento conservador.
Métodos Estudo retrospectivo de 20 pacientes (21 ombros), 17 mulheres (81%) e 3 homens (19%), submetidos a artroplastia reversa de ombro no período de outubro de 2012 a setembro de 2017, para tratamento de artropatia de manguito rotador, operados por um único cirurgião em um único centro. Os pacientes foram avaliados pelo escore de disfunções do braço, ombro e mão (DASH, na sigla em inglês), pelo questionário genérico de avaliação de qualidade de vida SF-36 (SF-36), pela escala visual analógica de dor (EVA) e pelo escore da Universidade de Los Angeles – Califórnia (UCLA, na sigla em inglês). A média de idade na cirurgia foi de 66 anos (variação de 55 a 83 anos). O tempo de sintomas antes da realização da cirurgia foi de ∼ 2,5 anos (variação de 12 meses a 6 anos). O seguimento médio foi de 42,4 meses (variação de 19 a 56,7 meses).
Resultados A média dos escores pós-operatórios foi de 18,2 pontos no DASH; de 2 pontos na EVA, sendo 16 (77%) de dores leves, 4 (18%) de dores moderadas e 1 (5%) de dor intensa; de 29 pontos no UCLA, sendo 6 pacientes com resultado regular (28%), 10 pacientes com resultado bom (48%), e 5 pacientes com resultado excelente (24%); e de 63 pontos no SF-36. Tivemos como complicações quatro casos de notching, um caso de fratura de acrômio por estresse, e um caso de infecção pós-operatória.
Conclusões A artroplastia reversa do ombro apresenta bons resultados funcionais nos escores avaliados, propiciando melhora significativa na qualidade de vida dos pacientes.
Imaging Analysis of Onodi Cells on Cone-Beam Computed Tomography
Authors: Ali Ibrahim K. , Sansare Kaustubh , Karjodkar Freny , Saalim Mohd 
Published: December 2019

Introduction Onodi cells are the most posterior ethmoid air cells, and extend superolaterally to the sphenoid sinus. The identification of Onodi cells is essential to because they can have some significant anatomic variations and relationships to vital adjacent structures, like the optic canal, the sphenoid sinus, and the internal carotid artery.
Objective The present study aimed to assess the prevalence of Onodi cells and their position with respect to sphenoid sinus. To the authors' best knowledge, this is the first study that uses cone-beam computed tomography (CBCT) to assess the prevalence and position of Onodi cells.
Methods We collected CBCT scan records from November 1st, 2016, to July 31st, 2017; the patients who fulfilled the eligibility criteria were included in the present study. The CBCT scans were reviewed by two independent observers. The descriptive statistics was performed using the Statistical Package for the Social Sciences (SPSS, SPSS, Inc., Chicago IL, US) software, version 17.0. A cross-tabulation of gender with the presence and position of Onodi cells was evaluated using the Chi-squared (χ2) test. The inter- and intraobserver agreements were evaluated using Kappa (κ) statistics.
Results Onodi cells were identified in 86 (42.8%) out of 201 patients. A subgroup analysis revealed that Onodi cells were present in 45 (43.3%) female and 41 (42.3%) male patients. The position of the Onodi cells was superior with respect to the sphenoid sinus in 43 (50%) of the patients, superolateral in 36 (41.9%), and lateral to the sphenoid sinus in 7 (8.1%) of the patients.
Conclusion The present study indicated a high prevalence of Onodi cells, with approximately equal distribution among males and females, and mostly superior in position in relation to the sphenoid sinus.
The Anatomy and Anatomical Variations of the Round Window Prechamber and Their Implications on Cochlear Implantation: An Anatomical, Imaging, and Surgical Study
Authors: Mehanna Ahmed Mohamed , Abdelnaby Moustafa Mohamed , Eid Mohamed 
Published: December 2019

Introduction Over the last decades, there has been a tremendous increase in the number of cochlear implant recipients and, consequently, there is a recent increase of interest in the proper understanding of the anatomy of the round window (RW), which is the most important anatomical land mark during cochlear implant surgery.Objectives The present study was undertaken to assess the detailed surgical and radiological anatomy of the RW prechamber; its shape, directions, measurements, common anatomic variations, and its relationships with different surrounding structures as related to cochlear implantation.Methods A total of 20 cadaveric specimens of human temporal bone were microscopically dissected for the anatomical assessment of the measurements of the RW and its relation to surrounding structures in the tympanum. A total of 20 patients were subjected to cochlear implantation, and a radiological and surgical assessment of the anatomy of their RW prechambers was performed.Results The distances between the RW and the facial canal (FC), the jugular fossa (JF), the carotid canal (CC), and the oval window (OW) were measured. Among the cases subjected to cochlear implantation, the infracochlear tunnel was studied radiologically; the lengths of the anterior and posterior pillars were assessed, and the relation with the direction at which the RW faces was statistically analyzed.Conclusions Proper understanding of the topographic anatomy of the RW, including its direction of opening and the distances from different adjacent structures in the tympanum, is essential for a successful cochlear implantation surgery, since it can help decision-making before the surgery and is useful to avoid many complications, such as misplaced electrode and iatrogenic injury to the surrounding structures.
Importance of Facial Plastic Surgery Education in Residency: A Resident Survey
Authors: Curti Steven A. , Jordan J. Randall 
Published: December 2019

Abstract
Introduction Facial plastic and reconstructive surgery (FPRS) is a key part of the curriculum for otolaryngology residents. It is important to gain an understanding of the breadth of exposure and level of competence residents feel with these concepts during their residency.
Objective To determine the level of FPRS exposure and training otolaryngology residents receive during their residency.
Methods A survey was emailed to all Accreditation Council for Graduate Medical Education (ACGME) accredited otolaryngology residents. The survey aimed to find the level of exposure to FPRS procedures otolaryngology residents get and how confident they feel with their training in cosmetic FPRS.
Results A total of 213 residents responded to the survey for an overall response rate of 13.4%. There was an even mixture of residents from all postgraduate year (PGY) levels, with 58% of respondents being male. Almost all (98%) of the residents felt FPRS was important to otolaryngology residency training. Exposure to procedures varied with 57% performing or assisting with cosmetic minor procedures, 81% performing or assisting with cosmetic major procedures, and 93% performing or assisting with reconstructive procedures. Only 49% of residents felt their programs either very or somewhat adequately prepared them in cosmetic facial plastic surgery.
Conclusion There was a wide variability in the FPRS procedure exposure. Most residents felt procedures were a vital part of otolaryngology residency training, but not all were able to participate in them. Only half of the residents felt well-prepared in cosmetic procedures.
An 86-Year-Old Female with Mitral Regurgitation and Significant Pectus Excavatum
Authors: Tasar Raphael , Tkebuchava Sophie , Diab Mahmoud , Doenst Torsten 
Published: December 2019

Abstract
Background We report the case of minimally invasive mitral valve repair in an 86-year-old female with symptomatic structural mitral regurgitation and severe pectus excavatum.
Case Description The case summarizes four areas of repetitive heart team discussions. First, should an 86-year-old patient still be treated invasively? Second, if so, should treatment be interventional or surgical? Third, if surgical, should we replace or repair at that age and fourth which surgical access is best with respect to her chest deformation?
Conclusion We chose to surgically repair the valve using a minimally invasive approach. The patient was extubated 3 hours after surgery and discharged after 7 days.
Biomechanical Comparison of Two Locking Plate Constructs for the Stabilization of Feline Tibial Fractures
Authors: Hottmann Natasha M. , Johnson Matthew D. , Banks Scott A. , Tuyn David , Lewis Daniel D. 
Published: December 2019

Abstract
Objectives The aim of this study was to compare the biomechanical characteristics of locking compression plate (LCP) and conical coupling plate (CCP) constructs for the stabilization of experimentally induced gap fractures in cat tibiae.
Materials and Methods Pelvic limbs were harvested from eight cat cadavers. Paired tibiae were stripped of all soft tissues, and randomly assigned to the LCP or CCP stabilization group. An eight-hole 2.7 mm LCP or a six-hole 2.5 mm CCP was applied to the medial surface of each tibia. A 1-cm segment of the tibia was excised centrally beneath the plate. The specimens were potted, then tested in non-destructive four-point craniocaudal and mediolateral bending, followed by non-destructive axial compression. Each construct was subsequently loaded to failure in axial compression. Bending and axial stiffness, yield load and failure load were calculated for each specimen.
Results The LCP constructs were significantly stiffer than the CCP constructs when subjected to non-destructive bending and axial loading. Craniocaudal bending stiffness was significantly greater than mediolateral bending stiffness for both constructs. Yield load and failure load were significantly greater for LCP constructs compared with CCP constructs.
Clinical Significance LCP may be a more suitable implant for stabilizing complex diaphyseal tibial fractures in cats. Additional supplemental fixation should be considered when using CCP to stabilize unreconstructed diaphyseal tibial fractures in cats. Further clinical investigation of both implants is recommended.