bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors
Authors: Hasbi Ahmed , Nguyen Tuan , Rahal Haneen , Manduca Joshua D. , Miksys Sharon , Tyndale Rachel F. , Madras Bertha K. , Perreault Melissa L. , George Susan R. 
Published: February 2020

AbstractDepression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is involved in depression- and anxiety-like behavior, the possibility that the receptor complex may have a role in mediating sex differences in such behaviors and related biochemical signaling was explored.In non-human primate caudate nucleus and in rat striatum, females expressed higher density of D1-D2 heteromer complexes and a greater number of D1-D2 expressing neurons compared to males. In rat, the sex difference in D1-D2 expression levels occurred even though D1 receptor expression was lower in female than in male with no difference in D2 receptor expression. In behavioral tests, female rats showed faster latency to depressive-like behavior and a greater susceptibility to the pro-depressive and anxiogenic-like effects of D1-D2 heteromer activation by low doses of SKF 83959, all of which were ameliorated by the selective heteromer disrupting peptide, TAT-D1. The sex difference observed in the anxiety test correlated with differences in low-frequency delta and theta oscillations in the nucleus accumbens. Analysis of signaling pathways revealed that the sex difference in D1-D2 heteromer expression led to differences in basal and heteromer-stimulated activities of two important signaling pathways, BDNF/TrkB and Akt/GSK3/β-catenin.These results suggest that the higher D1-D2 heteromer expression in female may significantly increase predisposition to depressive-like and anxiety-like behavior in female animals.
The non-uniqueness of solution for initial value problem of impulsive differential equations involving higher order Katugampola fractional derivative
Authors: Zhang Xian-Min 
Published: February 2020

AbstractIn this paper we consider the initial value problem for some impulsive differential equations with higher order Katugampola fractional derivative (fractional order $q \in (1,2]$q∈(1,2]). The systems of impulsive higher order fractional differential equations can involve one or two kinds of impulses, and by analyzing the error between the approximate solution and exact solution it is found that these impulsive systems are equivalent to some integral equations with one or two undetermined constants correspondingly, which uncover the non-uniqueness of solution to these impulsive systems. Some numerical examples are offered to explain the obtained results.
Antibiotic resistance in patients with clinical features of healthcare-associated infections in an urban tertiary hospital in Sierra Leone: a cross-sectional study
Authors: Lakoh Sulaiman , Li Letian , Sevalie Stephen , Guo Xuejun , Adekanmbi Olukemi , Yang Guang , Adebayo Oladimeji , Yi Le , Coker Joshua M. , Wang Shuchao , Wang Tiecheng , Sun Weiyang , Habib Abdulrazaq G. , Klein Eili Y. 
Published: February 2020

Abstract
Background
Available data on antibiotic resistance in sub-Saharan Africa is limited despite its increasing threat to global public health. As there is no previous study on antibiotic resistance in patients with clinical features of healthcare-associated infections (HAIs) in Sierra Leone, research is needed to inform public health policies. Our study aimed to assess antibiotic resistance rates from isolates in the urine and sputum samples of patients with clinical features of HAIs.

Methodology
We conducted a cross-sectional study of adult inpatients aged ≥18 years at Connaught Hospital, an urban tertiary care hospital in Freetown between February and June 2018.

Results
Over the course of the study, we enrolled 164 patients. Risk factors for HAIs were previous antibiotic use (93.3%), comorbidities (58.5%) and age (≥65 years) (23.9%). Of the 164 samples, 89.6% were urine. Bacterial growth was recorded in 58.8% of cultured specimens; the type of specimen was an independent predictor of bacterial growth (p < 0.021). The most common isolates were Escherichia coli and Klebsiella pneumoniae; 29.2% and 19.0% in urine samples and 18.8% and 31.3% in sputum samples, respectively.
The overall resistance rates were 58% for all extended-spectrum beta-lactamase (ESBL)-producing organisms, 13.4% for carbapenem-resistant non-lactose fermenting gram-negative bacilli, 8.7% for carbapenem-resistant Acinetobacter baumannii (CRAB) and 1.3% for carbapenem-resistant Enterobacteriaceae (CRE). There were no carbapenem-resistant P. aeruginosa (CRPA) isolates but all Staphylococcus aureus isolates were methicillin-resistant S. aureus.

Conclusion
We demonstrated a high prevalence rate of ESBL-producing organisms which are a significant burden at the main tertiary hospital in Sierra Leone. Urgent action is needed to strengthen microbiological diagnostic infrastructure, initiate surveillance on antibiotic resistance and develop and implement policy framework on antibiotic stewardship.
A revised short version of the compassionate love scale for humanity (CLS-H-SF): evidence from item response theory analyses and validity testing
Authors: Chiesi Francesca , Lau Chloe , Saklofske Donald H. 
Published: February 2020

Abstract
Background
Compassionate love is defined as awareness and understanding of one’s suffering, connecting with the distress, and being emotionally and cognitively moved to alleviate suffering. The Compassionate Love Scale for Humanity (CLS-H) was developed to measure compassion towards strangers who need help and/or are vulnerable. The present study aimed to develop an abbreviated version of the CLS-H using item response theory to provide a precise and non-redundant compassion measure for use in research and practice.

Methods
Undergraduate students (N = 790; 65.8% females) completed the CLS-H and other measures intended to establish external validity. Items for the short version were selected based on high amounts of information and taking into account the content coverage of the construct.

Results
The shortened scale consisted of 9 items and performed well in measuring a large spectrum of the underlying construct with acceptable reliability. In terms of validity, the previously observed pattern of correlations was confirmed demonstrating positive associations between compassionate love and measures of self-esteem, positive affect, and life satisfaction, as well as negative associations with negative affect and anxiety.

Conclusions
Using IRT, we obtained a brief, precise, and valid tool for assessing compassionate love.
Factors related to childbearing intentions among women: a cross-sectional study in health centers, Saveh, Iran
Authors: Araban Marzieh , Karimy Mahmood , Armoon Bahram , Zamani-Alavijeh Fereshteh 
Published: February 2020

Abstract
Background
One of the most important demographic challenges over the recent three decades in the world has been a significant fall in the fertility rate. This study aimed to investigate factors related to childbearing intentions among a sample of Iranian women.

Methods
A cross-sectional study of a sample of Iranian married women attending 8 centers in Saveh was conducted in 2015. A total of 483 married women 15–49 years old participated in this study. A questionnaire was used to collect data about demographics, attitude, subjective norms, marital satisfaction, social support, hopefulness, and behavioral intentions of childbearing.

Results
Overall, 62% of women in the study intended to have children in the next 2 years. The group willing to have children had a higher score on attitude, subjective norms, hopefulness, perceived social support, and marital satisfaction compared to the group unwilling to have children. Also, the regression results revealed that the variables of age, literacy status, employment status, husband literacy, women and husband occupation status, attitude, subjective norms, hopefulness, perceived social support, and marital satisfaction were significant predicting factors for childbearing intention (P < 0.05).

Conclusions and recommendations
The findings highlighted the importance of psychological factors such as marital satisfaction and social support in the childbearing process. Thus, health system planners should pay more attention to these determinants of fertility intention.
Liver disease during and after hematopoietic stem cell transplantation in adults: a single-center Egyptian experience
Authors: Abdelbary Haitham , Magdy Rasha , Moussa Mohammed , Abdelmoaty Inas 
Published: February 2020

Abstract
Background
Hepatic complications are a well-known cause of both early and late mortality and morbidity in hematopoietic stem cell transplant (HSCT) recipients. Early diagnosis and management of hepatic complications is important in order to commence appropriate therapy. Conditioning regimens, acute and chronic graft versus host disease, sinusoidal obstruction syndrome, and infections among others represent major hepatic complications for the transplant recipient. We assessed liver function tests, viral markers, polymerase chain reaction, abdominal ultrasound, portal, and hepatic venous duplex in 88 patients underwent autologous and 102 patients underwent allogeneic transplant as well as liver biopsy in selected patients in this retrospective study and evaluated early and late hepatic complications and their impact on transplant outcome.

Results
The major cause of hepatic injury in allogeneic patients is the conditioning regimen (38.8%) followed by acute GVHD (14.7%), after day +100 chronic hepatic GVHD is the primary cause of liver injury which occurred in about 40% of allogeneic patients. In autologous patients, the first cause of hepatotoxicity is also conditioning regimen involving 27.9% of patients followed by flare of viral hepatitis in 7.9% and sepsis in 6.3% of cases. The prevalence of HCV, HBV, and CMV is 19%, 16%, and 8%, respectively.

Conclusion
In our study, conditioning regimens, acute and chronic hepatic GVHD are frequent causes of hepatic injury following allogeneic HSCT while conditioning regimens, flare of viral hepatitis, and sepsis represent the most common causes of hepatic injury following autologous HSCT.
Women Empowerment or Feminism: Facts and Myths about Feminization of Medical Education
Authors: Baig Lubna Ansari 
Published: February 2020

doi: https://doi.org/10.12669/pjms.36.3.2396
How to cite this:Baig LA. Women Empowerment or Feminism: Facts and Myths about Feminization of Medical Education. Pak J Med Sci. 2020;36(3):303-305. doi: https://doi.org/10.12669/pjms.36.3.2396
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Irreducible holonomy groups and first integrals for holomorphic foliations
Authors: León Victor , Martelo Mitchael , Scárdua Bruno 
Published: February 2020

Abstract
We study groups of germs of complex diffeomorphisms having a
property called irreducibility. The notion is motivated by the
similar property of the fundamental group of the complement of an
irreducible hypersurface in the complex projective space. Natural
examples of such groups of germ maps are given by holonomy groups
and monodromy groups of integrable systems (foliations) under
certain conditions. We prove some finiteness results for these
groups extending previous results in [D. Cerveau and F. Loray,
Un théorème de Frobenius singulier via l’arithmétique élémentaire,
J. Number Theory 68 1998, 2, 217–228].
Applications are given to the framework of germs of holomorphic
foliations. We prove the existence of first integrals under certain
irreducibility or more general conditions on the tangent cone of
the foliation after a punctual blow-up.
Classification of indecomposable involutive set-theoretic solutions to the Yang–Baxter equation
Authors: Rump Wolfgang 
Published: February 2020

Abstract
Using the theory of cycle sets and braces,
non-degenerate indecomposable
involutive set-theoretic solutions to the Yang–Baxter equation are classified
in terms of their universal coverings and their fundamental group. The
universal
coverings are characterized as braces with an adjoint orbit generating the
additive group. Using this description, all coverings of non-degenerate
indecomposable cycle sets are classified. The method is illustrated by
examples.
Alexandroff topologies and monoid actions
Authors: Chiaselotti Giampiero , Infusino Federico G. 
Published: February 2020

Abstract
Given a monoid S acting (on the left) on a set X, all the subsets of X which are invariant with respect to such an action constitute the family of the closed subsets of an Alexandroff topology on X.
Conversely, we prove that any Alexandroff topology may be obtained through a monoid action.
Based on such a link between monoid actions and Alexandroff topologies, we firstly establish several topological properties for Alexandroff spaces bearing in mind specific examples of monoid actions.
Secondly, given an Alexandroff space X with associated topological closure operator σ, we introduce a specific notion of dependence on union of subsets.
Then, in relation to such a dependence, we study the family

𝒜

σ
,
X

{\mathcal{A}_{\sigma,X}}

of the closed subsets Y of X such that, for any

y
1

,

y
2

∈
Y

{y_{1},y_{2}\in Y}

, there exists a third element

y
∈
Y

{y\in Y}

whose closure contains both

y
1

{y_{1}}

and

y
2

{y_{2}}

.
More in detail, relying on some specific properties of the maximal members of the family

𝒜

σ
,
X

{\mathcal{A}_{\sigma,X}}

, we provide a decomposition theorem regarding an Alexandroff space as the union (not necessarily disjoint) of a pair of closed subsets characterized by such a dependence.
Finally, we refine the study of the aforementioned decomposition through a descending chain of closed subsets of X of which we give some examples taken from specific monoid actions.
A Bayesian inference for the penalized spline joint models of longitudinal and time-to-event data: A prior sensitivity analysis
Authors: Thi Thu Pham Huong , Pham Hoa , Nur Darfiana 
Published: February 2020

AbstractBayesian approaches have been used in the literature to estimate the parameters for joint models of longitudinal and time-to-event data. The main aim of this paper is to analyze the impact of prior distributions on estimating parameters in a proposed fully Bayesian analysis setting for the penalized spline joint models. To achieve this aim, the joint posterior distribution of parameters in survival and longitudinal submodels is presented. The Markov chain Monte Carlo (MCMC) algorithm is then proposed, which consists of the Gibbs sampler (GS) and Metropolis Hastings (MH) algorithms to sample for the target conditional posterior distributions. The prior sensitivity analysis for the baseline hazard rate and association parameters is performed through simulation studies and a case study.
The synthesis and crystal structure of 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carboxamide–tetrahydrofuran (1/1), C16H14N4Cl2F6O3S
Authors: Chen Lianqing , Yang Gengtao , Wu Zhongda 
Published: February 2020

Abstract
C16H14N4Cl2F6O3S, monoclinic, P21/c (no. 14), a = 10.927(3) Å, b = 13.542(3) Å, c = 15.744(4) Å, β = 107.360(4)°, V = 2223.6(10) Å3, Z = 4, R
gt(F) = 0.0480, wR
ref(F
2) = 0.1471, T = 294.15 K.
The crystal structure of 2-p-fluorophenyl-5-dihydroxymethyl-1,3,4-oxadiazole, C9H7FN2O3
Authors: Zhao Yong-Li , Ma Lan-Lan , Liu Xue-Di , Sui Yi , Chai Hui-Fang 
Published: February 2020

Abstract
C9H7FN2O3, triclinic, P1̅ (no. 2), a = 14.467(3) Å, b = 7.4629(14) Å, c = 8.9512(18) Å, α = 90°, β = 104.759(4)°, γ = 90°, V = 934.5(3) Å3, Z = 4, R
gt(F) = 0.0421, wR
ref(F
2) = 0.1173, T = 273 K.
Musement: The activity of the brain’s default mode network
Authors: Duarte Antonio 
Published: February 2020

Abstract
The main purpose of this article is to identify the inner human activity Peirce calls musement with the mental processes that arise through the workings of the brain’s default mode network. This network is a specific, recently anatomically defined brain system, which is most active when individuals are not focused on the external environment. In doing so, musement, which was defined by Peirce over a hundred years ago, will finally be situated within what today we understand as its neurobiological origin.
Identification of Suppressors oftop-2Embryonic Lethality inCaenorhabditis elegans
Authors: Bhandari Nirajan , Rourke Christine , Wilmoth Thomas , Bheemreddy Alekya , Schulman David , Collins Dina , Smith Harold E , Golden Andy , Jaramillo-Lambert Aimee 
Published: February 2020

AbstractTopoisomerase II is an enzyme with important roles in chromosome biology. This enzyme relieves supercoiling and DNA and RNA entanglements generated during mitosis. Recent studies have demonstrated that Topoisomerase II is also involved in the segregation of homologous chromosomes during the first meiotic division. However, the function and regulation of Topoisomerase II in meiosis has not been fully elucidated. Here, we conducted a genetic suppressor screen in Caenorhabditis elegans to identify putative genes that interact with topoisomerase II during meiosis. Using a temperature-sensitive allele of topoisomerase II, top-2(it7ts), we identified eleven suppressors of top-2-induced embryonic lethality. We used whole-genome sequencing and a combination of RNAi and CRISPR/Cas9 genome editing to identify and validate the responsible suppressor mutations. We found both recessive and dominant suppressing mutations that include one intragenic and 10 extragenic loci. The extragenic suppressors consist of a known Topoisomerase II-interacting protein and two novel interactors. We anticipate that further analysis of these suppressing mutations will provide new insights into the function of Topoisomerase II during meiosis.
SACRED AREAS OF SOUTHEAST OF KYIV-PODIL (XI–XIII CENTURIES)
Authors: Sahaidak Mykhailo , Ivakin Vsevolod , Taranenko Serhiy , Пефтіць Дмитро 
Published: February 2020

The article is devoted to sacred areas located in the south-eastern part of Old-Rus Podil district. This area has remained poorly investigated for a long time compared to other areas of this OldKyiv region. Archaeological researches of period 2007–2015 greatly expanded our understanding of the south-eastern part of old Podil. In this paper, we tried to reconstruct the sacred loci of this territory.In the tenth century, Kyiv consisted of a populated town – a large coastal area – Podil and of small sacral-administrative part – Detinets on Zamkova Hill and the necropolis on the Old Kyiv Hill. Due to active development of a new city in the days of the reign of Vladimir son of Svyatoslav and his son Yaroslav the Wise, inhabitants of Podil, now Christians, have had to look for another place to bury their dead. They were forced to look for areas in the territory without mass urban development.Henceforth cemeteries are beginning to play a significant role in shaping the structure of the medieval town of Kyiv-Podil. Several cemeteries were located at the extreme points of the settlement area, which, due to waterlogging and flood threats were unsuitable for life. It was proposed to use the term to define such cemeteries in the structure of ancient Podil – “outlying cemeteries”. Three of these cemeteries and one single burial excavated in the south-eastern part of ancient Podil. Cemeteries found on the Naberezhno-Khreschatytska, 1-а str. and Naberezhno-Khreschatytska, 9 str. belong to the earliest Podol burial grounds, their active functioning on the XI century.The cemetery opened in 2015 at the Postal Square and burial of women (Petra Sagaydachnogo str., 6-в ) belong to another chronological period. They date back to the XII – the first half of the XIII century. Recent studies have shown that a sufficiently large area in the south-eastern outskirts of Old-Rus Podil were unsuitable for settlement and so they are often used for a cemetery.
Efek Aerasi terhadap Perubahan Residu H2O2 Air Fermentasi Mocaf (Modified Cassava Flour)
Authors: Yaqin Nurul , Al-Baarri Ahmad Ni'matullah , Budihardjo Mochamad Arief , Widayat Widayat 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui perubahan kadar H2O2 yang berpotensi menjadi pencemar lingkungan beserta parameter kualitas air fermentasi mocaf (AFM) lainnya setelah diberikan perlakuan aerasi. Limbah mocaf yang diberikan perlakuan aerasi mengalami penurunan kadar H2O2 lebih besar dari non aerasi. Berdasarkan uji beda T-test antara perlakuan aerasi dengan non aerasi kadar H2O2 memiliki perbedaan yang signifikan (sig. p= 0,018, p<0,05). AFM non aerasi mengalami penurunan L* sebesar 5,9%, sedangkan perlakuan aerasi menurun lebih besar dengan persentase penurunan sebesar 15,8%. TDS AFM tidak mengalami perbedaan yang signifikan antara perlakuan aerasi dengan non aerasi (P= 0,226 ,p>0,05) demikian juga dengan pameter turbiditas (P= 0,117, P>0,05) dan OD 610 nm (P= 0,987, P> 0,05).
Comparison of the role of letrozole & clomiphene citrate as a first line ovulation induction drug in infertile women with polycystic ovary syndrome
Authors: Maitra Camelia , Hegde Rashm 
Published: February 2020

To compare the role between Clomiphene Citrate & letrozole for infertile patients with Polycystic Ovary Syndrome as an ovulation induction agent & which drug can be chosen as a first line ovulation induction agent in future.: This prospective study was carried at SSIMS & RC OBG OPD. Total 50 patients of PCOS (diagnosed by Rotterdam criterion) were included in this study. In this clinical trial out of 50 patients, 25 patients received Clo miphene Citrate 100mg (n=25) and rest 25 patients received Letrozole 2.5mg (n=25) daily since day 2-6 or3-7 of menstrual cycle. Follicular respose was carried out from day 9 by trans-vaginal sonogram till atleast 1 mature follicle (18-22mm) was detected & hCG was administered at a dose of 5000 IU. Timed intercourse was advised 24-36 hours after hCG injection. The number of Follicles, Endometrial Thickness, Ovulation rate & Pregnancy rate were measured in both groups. Monofollicular development was statistically significantly, greater in the Let group (CC 61.9%, Let 86.9%). There was also statistically significant difference between the two groups in endometrial thickness (CC 7.86±1.25mm, Let 9.18±1.49mm). Similarly, The ovulation rate was 84%% in CC group and 92% in Let group. The pregnancy rate was 20% in CC group and 36% in Let group. Letrozole might be an acceptable alternative to clomiphene citrate to induce ovulation and pregnancy in PCOS patients.