bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloud cover changes driven by atmospheric circulation in Europe during the last decades
Authors: Sfîcă Lucian , Beck Christoph , Nita Andrei‐Ion , Voiculescu Mirela , Birsan Marius‐Victor , Philipp Andreas 
Published: September 2020

AbstractDue to its complex role within the radiation budget of the Earth, cloud cover plays an important role in climate variability at local, regional or continental scale. Consequently, there is a need for better understanding the causes and feedbacks of changes in cloud cover. We aim at investigating the response of cloud cover to changes in atmospheric circulation for 1981–2014. This is done based on the application of automated weather type classification from COST733 synoptic classifications software, which helps in identifying a variety of atmospheric circulation types for selected domains. Two major spatial changes in cloud cover over Europe are identified, in connection with atmospheric circulation, associated with the latitudinal shift towards the north of the westerly circulation. The first one is related to a decrease of the cloud cover over the inner continent and especially in the East of Europe in connection with an increase of circulation types associated with high pressures centers development over the central and northern part of the continent. The second one, which is weaker in intensity, indicates an increase of cloud cover in the south‐western part of Europe as a result of a decrease in circulation types induced by the development of the Azores High and its northeastward ridges. The changes in cloud cover distribution and also in radiation fluxes, imposed by these shifts in atmospheric circulation over the continent, are higher in the Eastern and Central Europe.
Expression and clinical implications of leucine‐rich repeat containing 15 (LRRC15) in osteosarcoma
Authors: Cui Juncheng , Dean Dylan , Wei Ran , Hornicek Francis J. , Ulmert David , Duan Zhenfeng 
Published: September 2020

AbstractLeucine‐rich repeat containing 15 (LRRC15) is a member of the leucine‐rich repeat superfamily that is overexpressed in various cancers and associated with higher tumor grade and aggression. Despite its known tumorigenicity, its roles within osteosarcoma are unknown, prompting us to evaluate its expression and clinical significance within this rare yet aggressive cancer. Western blots showed differential expression of LRRC15 in the osteosarcoma cell lines MNNG/HOS, KHOS, 143B, MG63, Saos‐2, and U2OS. We additionally validated this positive expression, as well as sublocalization to the cell membrane, with immunofluorescence. A tissue microarray constructed from 69 osteosarcoma patient tissues was immunohistochemically stained for LRRC15 expression, stratified, and used for clinicopathological analysis. Publicly available databases on LRRC15 expression, including RNA sequencing data from the Therapeutically Applicable Research to Generate Effective Treatments on Osteosarcoma (TARGET‐OS) and the Gene Expression database of Normal and Tumor tissues 2 (GENT2) were also analyzed. We found 63 of the 69 (91.3%) patient tissues exhibited some degree of LRRC15 immunostaining, including no staining (6 of 69, 8.7%), 1+ staining (12 of 69, 17.4%), 2+ staining (25 of 69, 36.2%), and 3+ staining (26 of 69, 37.7%). The patients with osteosarcomas having elevated LRRC15 expression demonstrated comparatively increased metastasis, chemoresistance, and shorter 5‐year survival rates. Our analysis of the TARGET‐OS and GENT2 databases also showed increased LRRC15 gene expression in osteosarcoma. Taken together, our study supports LRRC15 as a prognostic biomarker and emerging therapeutic target in osteosarcoma.
The Hidden Burden of Community Enteral Feeding on the Emergency Department
Authors: Barrett Diane , Li Vincent , Merrick Sue , Murugananthan Aravinth , Steed Helen 
Published: September 2020

AbstractBackgroundEnteral feeding tubes are associated with their most serious complications in the days and weeks after insertion, but there are limited published data in the literature on late complications and the implications for the healthcare service.MethodsThis is a retrospective observational study of attendances to a UK hospital emergency department (ED), with enteral tube complications as the primary reason for attendance.ResultsOver 24 months, 139 attendances were recorded. Dislodged tubes and blocked tubes accounted for the majority of complications and subsequent admissions, with a mixture of enteral tube types being associated with both. Thirty‐five percent of patients were admitted, and the average healthcare cost per attendance was $1071.ConclusionEnteral tube complications can place a hidden burden on the patient, the ED, and healthcare costs. More work on education and supporting caregivers to resolve problems themselves could reduce the burden on busy EDs.
Synthesis and Properties of Two Amino Carboxylic Acid Gemini Surfactants
Authors: Xu Libo , He Zhirong , Han Fu , Zhou Yawen , Xu Baocai 
Published: September 2020

AbstractThe number of hydrophilic and hydrophobic groups of a surfactant has a great influence on its property. Two Gemini surfactants, N,N″‘‐didodecyl‐N,N',N″,N″‘‐tetrapropionate triethylenetetramine and N,N'‐didodecyl‐N,N'‐dipropionate ethylenediamine (referred as DTPTT and DDPED), were prepared by Michael addition reaction of the didodecyl secondary amines with methyl acrylate. The didodecyl secondary amines were synthesized by nucleophilic substitution reaction of triethylenetetramine or ethylenediamine with bromododecane. The DTPTT and DDPED surfactants were characterized by mass spectrometry and proton nuclear magnetic resonance spectrometry. The surface activities of the DTPTT and DDPED aqueous solutions were studied by surface tension measurements. The surface tension and critical micelle concentration (cmc) of DDPED is smaller than that of DTPTT. The DDPED can reduce the surface tension of water to approximate 34 mN m−1 at concentration levels of 10−5 mol L−1. The aggregation behavior of the DTPTT and DDPED aqueous solution were studied by dynamic light scattering and transmission electron microscopy. Both surfactants can form spherical vesicles at a solution of about 3–5 times cmc of the Gemini surfactants. The foam property was determined by nitrogen blowing method. The DTPTT has relatively good foaming ability and DDPED has excellent foam stability. The foam volume of DDPED barely change within 1000s. The emulsion stability of the Gemini surfactants was determined by separation time of water from the emulsion. The emulsion stability of DDPED is equivalent to Tween 80. The DDPED Gemini surfactant with two hydrophilic carboxylic groups has better surface activity, foam stability, and can be used as an O/W emulsifier.
Study on degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion under field application
Authors: Bai Aijuan , Chen Ang , Chen Wuying , Luo Xiangwen , Liu Shaowen , Zhang Min , Liu Yong , Zhang Deyong 
Published: September 2020

AbstractBACKGROUNDPropiconazole is widely used to control fungal diseases in field crops, including celery and onion. The potential risk to the environment and human health has aroused much public concern. Therefore, it is significant to investigate the degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion.RESULTSA sensitive analytical method for determination of propiconazole residue in celery and onion was established and validated through high‐performance liquid chromatography tandem mass spectrometry. The average recovery rate of propiconazole ranged from 85.7% to 101.8%, with a relative standard deviation of 2.1–6.3%. For the dissipation kinetics, the data showed that propiconazole in celery and onion was degraded, with half‐lives of 6.1–6.2 days and 8.7–8.8 days respectively. In the terminal residue experiments, the residues of propiconazole were below 4.66 mg kg−1 in celery after application two or three times and were below 0.029 mg kg−1 in onion after application of three or four times with an interval of 14 days under the designed dosages. The chronic and acute dietary exposure assessments for propiconazole were valued by risk quotient, with all values being lower than 100%.CONCLUSIONPropiconazole in celery and onion was rapidly degraded following first‐order kinetics models. The dietary risk of propiconazole through celery or onion was negligible to consumers. The study not only offers a valuable reference for reasonable usage of propiconazole on celery and onion, but also facilitates the establishment of maximum residue limits in China. © 2020 Society of Chemical Industry
Saccharomyces cerevisiae as a delivery system of Zataria multiflora Boiss. essential oil as a natural preservative for food applications
Authors: Nakhaee Moghadam Maryam , Jamshidi Abdollah , Fazly Bazzaz BiBi Sedigheh , Azizzadeh Mohammad , Movaffagh Jebrail 
Published: September 2020

AbstractBACKGROUNDThe following study is an evaluation of the encapsulation, stability and release profile of Iranian Zateria multiflora boiss essential oil (ZEO) in Saccharomyces cerevisiae yeast cells. Encapsulation was performed with different essential oil / yeast weight ratios at different temperatures. The encapsulation efficiency and stability of the loaded yeasts and the release profiles of carvacrol and thymol (as the main active ingredients of ZEO) were also investigated.RESULTThe encapsulation efficiencies of carvacrol and thymol at a ZEO / yeast weight ratio of 1.25 were 30.9% ± 0.01% and 44.5% ± 0.02%, respectively. Loaded yeast cells were stable during the 4‐week storage period. Both carvacrol and thymol showed substantial releases of around 60% during the first hour and around 70% during the second hour at two different water temperatures, followed by steady release.CONCLUSIONZateria multiflora boiss essential oil can be encapsulated effectively in S. cerevisiae yeast cells, refrigerated without degradation, and released efficiently. Zateria multiflora boiss essential oil encapsulated into S. cerevisiae yeast may be used as a potential preservative for the food and drug industry. © 2020 Society of Chemical Industry
The immunomodulatory effects of Carapax Trionycis ultrafine powder on cyclophosphamide‐induced immunosuppression in Balb/c mice
Authors: Chen Xuhui , Wang Shasha , Chen Guangjing , Wang Zhirong , Kan Jianquan 
Published: September 2020

AbstractBACKGROUNDThere are abundant resources of Carapax Trionycis from soft‐shelled turtle processing wastes each year in China. Our preliminary work showed that Carapax Trionycis ultrafine powder (CTUP) obtained using ball‐milling with a particle size of 2.24 μm (D0.025) contained more active ingredients. The CTUP D0.025 has a good bioaccessibility, but there has been no report about the immunomodulatory function of CTUP. Therefore, using a cyclophosphamide‐induced immunosuppression mice model, we investigated the immunomodulatory effects of CTUP D0.025.RESULTSThe results indicated that CTUP D0.025 administration significantly improved the immune organ (bone marrow, thymus and spleen) indices, ameliorated spleen tissue morphology and increased the capacity of splenocyte proliferation and the activity of macrophage phagocytosis. CTUP D0.025 also significantly promoted the secretion of cytokines (IL‐2, IL‐4, IL‐10, IFN‐γ and TNF‐α), improved the related mRNA expression levels of IL2, IFN‐γ, T‐bet and GATA3 in immunosuppressed mice and increased the production of serum hemolysin and the levels of IgG, IgM as well as complement C3. Moreover, CTUP D0.025 administration enhanced the antioxidant capacity of mice, exhibited a moderating effect on the damage of bone and skeletal muscle and improved the recovery of bone mineral density and calcium metabolism.CONCLUSIONSThese findings demonstrated that CTUP D0.025 had an effective immune‐enhancing function in immunosuppressive Balb/c mice and also exhibited anti‐osteoporosis properties. © 2020 Society of Chemical Industry
Postharvest LED lighting: effect of red, blue and far red on quality of minimally processed broccoli sprouts
Authors: Castillejo Noelia , Martínez‐Zamora Lorena , Gómez Perla A , Pennisi Giuseppina , Crepaldi Andrea , Fernández Juan A , Orsini Francesco , Artés‐Hernández Francisco 
Published: September 2020

AbstractBACKGROUNDThe main objective of this study was to evaluate physiological and quality changes of minimally processed broccoli sprouts illuminated during postharvest storage under blue, red and far‐red LED lighting as compared to darkness or illumination with fluorescent light, as control treatments.RESULTSMorphological and microbiological changes were determined during 15 days at 5 °C. In addition, total antioxidant activity and bioactive compound changes throughout the shelf life were also monitored. Results showed that far‐red LED lighting increased hypocotyl and sprout length, decreased microbial growth and improved the total antioxidant and scavenging activities, compared to darkness and fluorescent lighting treatments. However, it did not stimulate the biosynthesis of phenolic acids. In contrast, blue LED light reduced by 50% the total antioxidant capacity of broccoli sprouts compared to far‐red treatment, as well as morphological development. In addition, total scavenging activity was increased under far‐red LED light compared with the other treatments by 12–10% (darkness and fluorescence) and 33–31% (blue and red LEDs).CONCLUSIONSOur results suggest that minimally processed sprouts may benefit from LED lighting during shelf life in terms of quality, although further experiments should be conducted to optimize a proper exposure cycle and intensity aiming for use in the distribution chain. The results also open the way for further development towards the integration of this technology in the food distribution chain.
The Influence of Premigration Trauma Exposure and Early Postmigration Stressors on Changes in Mental Health Over Time Among Refugees in Australia
Authors: Stuart Jaimee , Nowosad Jemima 
Published: September 2020

AbstractAs a result of the precarious conditions in which they migrate, refugees are likely to have experiences that increase their risk of mental health problems. Refugees tend to be predisposed to relatively high levels of distress upon resettlement, and a key predictor of these issues is traumatic experiences that occur before their arrival. Despite high initial levels of ill‐health, on average, refugees tend to experience mental health recovery over time. However, both levels of mental health upon settlement and recovery over time may be negatively influenced by stressors in the postsettlement period. The present study examined changes in psychological distress and posttraumatic stress symptoms over 5 years among 2,169 refugees from various backgrounds, predominately from Iraq and Afghanistan, who participated in the Building a New Life in Australia (BNLA) study. A multivariate latent growth curve model found mental ill‐health decreased on average, β = −.21 for distress and β = −.31 for PTSD, ps < .001, and premigration trauma exposure predicted more initial PTSD symptoms and reduced recovery over time, βIntercept = .21, βSlope = −.54, p < .001. Postmigration stressors, such as loneliness, financial concerns, and cultural integration, predicted higher levels of mental health problems as well as reduced recovery over time. These findings suggest that beyond trauma exposure, the mental health of refugees upon resettlement and their recovery over time is impacted by stressors in the early resettlement period, which has important implications for interventions and services to support and encourage well‐being in refugee populations.
Hey Siri: How Effective are Common Voice Recognition Systems at Recognizing Dysphonic Voices?
Authors: Rohlfing Matthew L. , Buckley Daniel P. , Piraquive Jacquelyn , Stepp Cara E. , Tracy Lauren F. 
Published: September 2020

Objectives/HypothesisInteraction with voice recognition systems, such as Siri™ and Alexa™, is an increasingly important part of everyday life. Patients with voice disorders may have difficulty with this technology, leading to frustration and reduction in quality of life. This study evaluates the ability of common voice recognition systems to transcribe dysphonic voices.Study DesignRetrospective evaluation of "Rainbow Passage" voice samples from patients with and without voice disorders.MethodsParticipants with (n = 30) and without (n = 23) voice disorders were recorded reading the “Rainbow Passage”. Recordings were played at standardized intensity and distance‐to‐dictation programs on Apple iPhone 6S™, Apple iPhone 11 Pro™, and Google Voice™. Word recognition scores were calculated as the proportion of correctly transcribed words. Word recognition scores were compared to auditory–perceptual and acoustic measures.ResultsMean word recognition scores for participants with and without voice disorders were, respectively, 68.6% and 91.9% for Apple iPhone 6S™ (P < .001), 71.2% and 93.7% for Apple iPhone 11 Pro™ (P < .001), and 68.7% and 93.8% for Google Voice™ (P < .001). There were strong, approximately linear associations between CAPE‐V ratings of overall severity of dysphonia and word recognition score, with correlation coefficients (R2) of 0.609 (iPhone 6S™), 0.670 (iPhone 11 Pro™), and 0.619 (Google Voice™). These relationships persisted when controlling for diagnosis, age, gender, fundamental frequency, and speech rate (P < .001 for all systems).ConclusionCommon voice recognition systems function well with nondysphonic voices but are poor at accurately transcribing dysphonic voices. There was a strong negative correlation with word recognition scores and perceptual voice evaluation. As our society increasingly interfaces with automated voice recognition technology, the needs of patients with voice disorders should be considered.Level of Evidence4 Laryngoscope, 131:1599–1607, 2021
Expanding Data Collection for the MDSGene Database: X‐linked Dystonia‐Parkinsonism as Use Case Example
Authors: Pauly Martje G. , Ruiz López Marta , Westenberger Ana , Saranza Gerard , Brüggemann Norbert , Weissbach Anne , Rosales Raymond L. , Diesta Cid C. , Jamora Roland D.G. , Reyes Charles J. , Madoev Harutyun , Petkovic Sonja , Ozelius Laurie J. , Klein Christine , Domingo Aloysius 
Published: September 2020

ABSTRACTMDSGene is an online database on movement disorders that collates genetic and clinical knowledge using a standardized published literature abstraction strategy. This review is dedicated to X‐linked dystonia‐parkinsonism (XDP). We screened 233 citations and curated phenotypic and genotypic data for 414 cases. To reduce data missingness, we (1) contacted authors and engaged the research community to provide additional clinical and genetic information, and (2) revisited previously unpublished data from a cohort of XDP patients seen at our institution. Using these approaches, we expanded the cohort to 577 cases and increased information available for important clinical and genetic features such as age at onset, initial manifestation, predominant motor symptoms, functional impairments, and repeat size information. We established the use of mining unpublished data to expand the MDSGene workflow and present an up‐to‐date description of the phenomenology of XDP using an extensive collection of previously reported and unreported data. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Detection of prostate cancer DNA using tetrapods based disposable paper ecofriendly biosensor device
Authors: Gautam Aarti , Singhal Chaitali , Mishra Annu , John Alishba T. , Gautam Uttam K. , Abolhassani Reza , Adelung Rainer , Kumar Avasthi Devesh , Kumar Mishra Yogendra 
Published: September 2020

AbstractThe present work reports an enhancement in early diagnosis of DNA of prostate cancer by a rapid and sensitive biosensor. The genosensor platform was designed and fabricated using cost‐effective and disposable paper‐based electrodes. Herein, the bio‐nano‐interface was developed by immobilization of probe DNA of prostate cancer on the zinc oxide tetrapods modified paper electrode. The genosensor was characterized by scanning electron microscopy, transmission electron microscopy, synchrotron X‐ray photoelectron spectroscopy, cyclic voltammetry and impedance spectroscopy. The nano‐engineered genosensor was tested and found to be selective to prostate cancer. The sensor could detect as low as 1 pM of prostate cancer DNA with the linear detection range from 50 µM to 1 pM. The paper‐based genosensor also proved to be advantageous in terms of easy preparation, low specimen volume, homogenous distribution of nanostructures onto the surface and cost‐effectiveness. The present work demonstrates the enormous potential of DNA biosensor as a rapid and specific diagnostic tool to be used for the detection of prostate cancer DNA.
Bone nonunion management in children with a vascularized tibial periosteal graft
Authors: Soldado Francisco , Barrera‐Ochoa Sergi , Bergua‐Domingo Josep Maria , Domenech Pedro , Corona Pablo Salvador , Knorr Jorge 
Published: September 2020

AbstractBackgroundVascularized periosteal graft have demonstrated a tremendous bone healing capacity in children. The objective is to report outcomes on the use of vascularized tibial periosteal graft (VTPG) during bone reconstruction in a series of children with complex bone healing problems.Patients and methodsCases were collected retrospectively since May 2013 to May 2019, excluding cases of congenital pseudarthrosis of the tibia. Mean age at surgery was 12.8 (range 11–18) years. Indications included treatment of recalcitrant bone nonunion and the prevention of bone allograft‐host junction nonunion in seven and three patients, respectively. The periosteal flap, based on the anterior tibial vessels, was harvested as a free flap in six instances and as a pedicled flap in four.ResultsMean follow‐up was 25.2 months (range 8–36). The flap showed a 13.6 cm (range 9–16) and mean width 3.4 cm (range 2.7–3.9). Early bone union was achieved, initially through periosteal callus, followed by cortical union at mean times of 2 and 4 months, respectively, in nine cases. The flap was not successful in a patient with severe comorbidities. No donor site complications were registered.ConclusionsVTPG was fast and high effective for the treatment complex bone nonunion or the prevention of allograft nonunion in children.
A 35‐GHz high image rejection resistive mixer using a tunable resonator and a narrowband bandpass filter
Authors: Kim Jihoon 
Published: September 2020

AbstractA 35‐GHz high image rejection resistive mixer (IRM) is implemented using a tunable resonator and a narrowband bandpass filter (BPF). To obtain a high image rejection ratio (IRR) of more than 40 dB, a tunable resonator, which consists of inductive lines and varactors, is integrated inside a mixer. It can not only mitigate the mismatch of the resonating frequency through process variation and the parasitic effect but also be used as a radio frequency input matching circuit. A narrowband BPF based on coupled slow‐wave resonators is inserted before a mixer. The proposed IRM is fabricated by a commercial 0.15 μm gallium arsenide (GaAs) pseudo high electron mobility transistor (pHEMT) monolithic microwave integrated circuit process. The proposed IRM represents 42.2 dB IRR, a conversion loss of 11.6 dB, an input 1‐dB compression point (P−1dB) of more than 8 dBm, and a 35 dB local oscillator‐radio frequency isolation at 35 GHz.