bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Registry of Senior Australians outcome monitoring system: quality and safety indicators for residential aged care
Authors: Inacio Maria C , Lang Catherine , Caughey Gillian E , Bray Sarah C E , Harrison Stephanie L , Whitehead Craig , Visvanathan Renuka , Evans Keith , Corlis Megan , Cornell Victoria , Wesselingh Steve 
Published: July 2020

Abstract

Objectives
To introduce the Registry of Senior Australians (ROSA) Outcome Monitoring System, which can monitor the quality and safety of care provided to individuals accessing residential aged care. Development and examination of 12 quality and safety indicators of care and their 2016 prevalence estimates are presented.

Design
Retrospective.

Setting
2690 national and 254 South Australian (SA) aged care facilities.

Participants
208 355 unique residents nationally and 18 956 in SA.

Main Outcome Measures
Risk-adjusted prevalence of high sedative load, antipsychotic use, chronic opioid use, antibiotic use, premature mortality, falls, fractures, medication-related adverse events, weight loss/malnutrition, delirium and/or dementia hospitalisations, emergency department presentations, and pressure injuries.

Results
Five indicators were estimated nationally; antibiotic use (67.5%, 95% confidence interval (CI): 67.3–67.7%) had the highest prevalence, followed by high sedative load (48.1%, 95% CI: 47.9–48.3%), chronic opioid use (26.8%, 95% CI: 26.6–26.9%), antipsychotic use (23.5%, 95% CI: 23.4–23.7%) and premature mortality (0.6%, 95% CI: 0.6–0.7%). Seven indicators were estimated in SA; emergency department presentations (19.1%, 95% CI: 18.3–20.0%) had the highest prevalence, followed by falls (10.1%, 95% CI: 9.7–10.4%), fractures (4.8%, 95% CI: 4.6–5.1%), pressure injuries (2.9%, 95% CI: 2.7–3.1%), delirium and/or dementia related hospitalisations (2.3%, 95% CI: 2.1–2.6%), weight loss/malnutrition (0.7%, 95% CI: 0.6–0.8%) and medication-related events (0.6%, 95% CI: 0.5–0.7%).

Conclusions
Twelve quality and safety indicators were developed to monitor aged care provided to older Australians based on the synthesis of existing literature and expert advisory input. These indicators rely on existing data within the aged care and healthcare sectors, therefore creating a pragmatic tool to examine quality and unwarranted care variation.
Thermomechanical and enzyme-facilitated processing of soybean meal enhanced in vitro kinetics of protein digestion and protein and amino acid digestibility in weaned pigs
Authors: Ton Nu Mai Anh , Lupatsch Ingrid , Zannatta Joaquin S , Schulze Hagen , Zijlstra Ruurd T 
Published: July 2020

Abstract
Soybean meal (SBM) contains anti-nutritional factors (ANF) that may limit kinetics and total extent of protein digestion in pigs. This study evaluated the effects of thermomechanical and enzyme-facilitated (TE) processing on in vitro kinetics of crude protein (CP) digestion and CP and amino acid (AA) digestibility in weaned pigs. Each batch of SBM (48% CP) was divided into two parts: non-processed SBM as control vs. thermomechanical and enzyme-facilitated processed soybean meal (TES) as the experimental group. For digestion kinetics, samples (three batches of non-processed SBM vs. TES) were incubated in triplicate sequentially with pepsin at pH 3.5 for 1.5 h (stomach phase) and subsequently with pancreatin and bile extract at pH 6.8 for 0, 0.5, 1, 2, 4, or 6 h (small intestine phase). Protein was classified into CPfast, CPslow, and CPresistant corresponding to CP digested within the first 0.5 h, from 0.5 to 4 h, and after 4 h plus undigested CP, respectively. Eight weaned barrows (Large White × Duroc, 9.43 ± 0.40 kg) were surgically fitted with a T-cannula at the terminal ileum. Pigs were randomly assigned to a Youden square with three diets over four periods. The three diets were an N-free diet and two diets using 40% SBM or TES as the sole source of AA with Cr2O3 as an indigestible marker. Each period included sequentially a 5-d adaptation, 2-d collection of feces, and 2-d collection of ileal digesta. The TE processing reduced ANF content in TES by 91% for lectin, 22% for trypsin inhibitor activity, 75% for β-conglycinin, and 62% for glycinin compared with SBM. In vitro, TE processing increased (P &lt; 0.05) digested CP by 5.6% and enhanced the kinetics of CP digestion by tending to increase (P = 0.056) CPfast by 25% and reducing (P &lt; 0.05) CPslow and CPresistant by 48% and 11%, respectively. In pigs, TE processing increased (P &lt; 0.05) apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of CP in TES by 2.3% and 2.1%, respectively. The TE processing increased (P &lt; 0.05) AID and SID of all AA up to 3.3%, except for AID of Pro and SID of Pro, Gly, and Cys. The TE processing did not change reactive Lys or Lys:CP but increased (P &lt; 0.05) SID of Lys and reactive Lys by 3%. Combined, the greater in vitro digestion kinetics matched the greater in vivo AID and SID of CP in TES and lower ANF compared with SBM. Thus, TE processing created a protein source that is digested faster and to a greater extent than SBM, thereby lowering the chance of protein fermentation.
Identification of Edible Short- and Long-Horned Grasshoppers and Their Host Plants in East Africa
Authors: Leonard Alfonce , Khamis Fathiya M , Egonyu James P , Kyamanywa Samuel , Ekesi Sunday , Tanga Chrysantus M , Copeland Robert S , Subramanian Sevgan 
Published: July 2020

Abstract
There is a paucity of information on the edible grasshoppers and their host plants in East Africa. This study adopted morphological and molecular analysis to identify edible grasshoppers in Kenya and Uganda. The associated host plants were identified through molecular analysis of the gut contents of the grasshoppers. The cytochrome b and 16s gene primers were used for grasshopper DNA analysis; while matK gene primers were used for plant DNA analysis. All long-horned grasshoppers sampled were identified as Ruspolia differens (Serville) (Orthoptera: Tettigonidae); whereas short-horned grasshoppers were identified as Acanthacris ruficornis (Fabricius) (Orthoptera: Acrididae) and Cyrtacanthacris tatarica (L.) (Orthoptera: Acrididae). Host plants of A. ruficornis were Achyranthes aspera (L.), Centella virgata L.f. Drude, Digitaria gayana (Kunth), Galinsoga quadriradiata Ruiz and Pavon, and Triumfetta pilosa Roth; whereas those of C. tatarica were Alysicarpus rugosus (Willd.) DC and Teramnus uncinatus (L.) SW. Host plants of R. differens were Ageratum conyzoides (L.), Citrus depressa Hayata, Cynodon dactylon (L.), D. gayana, Eragrostis mexicana Hornem, Eucalyptus saligna SM., Indigofera arrecta Hochst. ex A. Rich., Persicaria nepalensis (L.), and Sorghum halepense (L.). Information on the host plants of edible grasshoppers can help in the development of their mass rearing protocols.
Summer roosts of “The revenant” flat-headed myotis, Myotis planiceps
Authors: Núñez-Rojo María Paulina , Arroyo-Cabrales Joaquín , Rivera-Téllez Emmanuel , Medellín Rodrigo A 
Published: July 2020

Abstract
The flat-headed myotis (Myotis planiceps) was declared extinct in 1996 but rediscovered in 2004, thus the reference to a revenant, one who came back from the dead, as it was declared extinct in 1996 but rediscovered in 2004. However, the species still faces serious extinction risk. To aid in the strategic planning and priorities for conservation, we studied roosting ecology. These bats inhabit the Chihuahuan Desert in one of the smallest distributional ranges of any mammal. Using radiotelemetry, we located 25 summer roosts, all in the skirts of dry leaves of yucca trees (Yucca carnerosana). We conclude that to roost, these bats search for clumps of tall yucca trees with a mean height of 3.93 m and mean width of skirts of 1.35 m.
Formation of planetary populations – III. Core composition and atmospheric evaporation
Authors: Alessi Matthew , Inglis Julie , Pudritz Ralph E 
Published: July 2020

ABSTRACT
The exoplanet mass–radius diagram reveals that super-Earths display a wide range of radii, and therefore mean densities, at a given mass. Using planet population synthesis models, we explore the key physical factors that shape this distribution: planets’ solid core compositions, and their atmospheric structure. For the former, we use equilibrium disc chemistry models to track accreted minerals on to planetary cores throughout the formation. For the latter, we track gas accretion during the formation and consider photoevaporation-driven atmospheric mass-loss to determine what portion of accreted gas escapes after the disc phase. We find that atmospheric stripping of Neptunes and sub-Saturns at small orbital radii (≲0.1 au) plays a key role in the formation of short-period super-Earths. Core compositions are strongly influenced by the trap in which they formed. We also find a separation between Earth-like planet compositions at small orbital radii ≲0.5 au and ice-rich planets (up to 50 per cent by mass) at larger orbits ∼1 au. This corresponds well with the Earth-like mean densities inferred from the observed position of the low-mass planet radius valley at small orbital periods. Our model produces planet radii comparable to observations at masses ∼1–3 M⊕. At larger masses, planets’ accreted gas significantly increases their radii to be larger than most of the observed data. While photoevaporation, affecting planets at small orbital radii ≲0.1 au, reduces a subset of these planets’ radii and improves our comparison, most planets in our computed populations are unaffected due to low-far ultraviolet fluxes as they form at larger separations.
The Tidal Disruption Event AT 2018hyz II: Light-curve modelling of a partially disrupted star
Authors: Gomez Sebastian , Nicholl Matt , Short Philip , Margutti Raffaella , Alexander Kate D , Blanchard Peter K , Berger Edo , Eftekhari Tarraneh , Schulze Steve , Anderson Joseph , Arcavi Iair , Chornock Ryan , Cowperthwaite Philip S , Galbany Lluís , Herzog Laura J , Hiramatsu Daichi , Hosseinzadeh Griffin , Laskar Tanmoy , Müller Bravo Tomás E , Patton Locke , Terreran Giacomo 
Published: July 2020

ABSTRACT
AT 2018hyz (= ASASSN-18zj) is a tidal disruption event (TDE) located in the nucleus of a quiescent E+A galaxy at a redshift of z = 0.04573, first detected by the All-Sky Automated Survey for Supernovae (ASAS-SN). We present optical+UV photometry of the transient, as well as an X-ray spectrum and radio upper limits. The bolometric light curve of AT 2018hyz is comparable to other known TDEs and declines at a rate consistent with a t−5/3 at early times, emitting a total radiated energy of E = 9 × 1050 erg. An excess bump appears in the UV light curve about 50 d after bolometric peak, followed by a flattening beyond 250 d. We detect a constant X-ray source present for at least 86 d. The X-ray spectrum shows a total unabsorbed flux of ∼4 × 10−14 erg cm−2 s−1 and is best fit by a blackbody plus power-law model with a photon index of Γ = 0.8. A thermal X-ray model is unable to account for photons &gt;1 keV, while a radio non-detection favours inverse-Compton scattering rather than a jet for the non-thermal component. We model the optical and UV light curves using the Modular Open-Source Fitter for Transients (MOSFiT) and find a best fit for a black hole of 5.2 × 106 M⊙ disrupting a 0.1 M⊙ star; the model suggests the star was likely only partially disrupted, based on the derived impact parameter of β = 0.6. The low optical depth implied by the small debris mass may explain how we are able to see hydrogen emission with disc-like line profiles in the spectra of AT 2018hyz (see our companion paper).
Base-intercalated and base-wedged stacking elements in 3D-structure of RNA and RNA–protein complexes
Authors: Baulin Eugene , Metelev Valeriy , Bogdanov Alexey 
Published: July 2020

Abstract
Along with nucleobase pairing, base-base stacking interactions are one of the two main types of strong non-covalent interactions that define the unique secondary and tertiary structure of RNA. In this paper we studied two subfamilies of nucleobase-inserted stacking structures: (i) with any base intercalated between neighboring nucleotide residues (base-intercalated element, BIE, i + 1); (ii) with any base wedged into a hydrophobic cavity formed by heterocyclic bases of two nucleotides which are one nucleotide apart in sequence (base-wedged element, BWE, i + 2). We have exploited the growing database of natively folded RNA structures in Protein Data Bank to analyze the distribution and structural role of these motifs in RNA. We found that these structural elements initially found in yeast tRNAPhe are quite widespread among the tertiary structures of various RNAs. These motifs perform diverse roles in RNA 3D structure formation and its maintenance. They contribute to the folding of RNA bulges and loops and participate in long-range interactions of single-stranded stretches within RNA macromolecules. Furthermore, both base-intercalated and base-wedged motifs participate directly or indirectly in the formation of RNA functional centers, which interact with various ligands, antibiotics and proteins.
Smoke-Free Air Interventions in Seven Latin American Countries: Health and Financial Impact to Inform Evidence-Based Policy Implementation
Authors: Bardach Ariel , Rodríguez María Belén , Ciapponi Agustín , Augustovski Federico , Andrea Alcaraz , Soto Natalie , Virgilio Sacha , Reynales-Shigematsu Luz Myriam , Roberti Javier , Pichón-Riviere Andrés 
Published: July 2020

Abstract

Introduction
Disease burden due to tobacco smoking in Latin America remains very high. The objective of this study was to evaluate the potential impact of implementing smoke-free air interventions on health and cost outcomes in Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, and Peru, using a mathematical model.

Aims and Methods
We built a probabilistic Monte Carlo microsimulation model, considering natural history, direct health system costs, and quality of life impairment associated with main tobacco-related diseases. We followed individuals in hypothetical cohorts and calculated health outcomes on an annual basis to obtain aggregated 10-year population health outcomes (deaths and events) and costs. To populate the model, we completed an overview and systematic review of the literature. Also, we calibrated the model comparing the predicted disease-specific mortality rates with those coming from local national statistics.

Results
With current policies, for the next 10 years, a total of 137 121 deaths and 917 210 events could be averted, adding 3.84 million years of healthy life and saving USD 9.2 billion in these seven countries. If countries fully implemented smoke-free air strategies, it would be possible to avert nearly 180 000 premature deaths and 1.2 million events, adding 5 million healthy years of life and saving USD 13.1 billion in direct healthcare.

Conclusions
Implementing the smoke-free air strategy would substantially reduce deaths, diseases, and health care costs attributed to smoking. Latin American countries should not delay the full implementation of this strategy.

Implications
Tobacco smoking is the single most preventable and premature mortality cause in the world. The Framework Convention on Tobacco Control, supported by the World Health Organization, introduced a package of evidence-based measures for tobacco control. This study adds quality evidence on the potential health effects and savings of implementing smoke-free air policies in countries representing almost 80% of the Latin America and the Caribbean population.
ABSOLUTE MEASUREMENT OF 14.57 MeV NEUTRON FLUENCE RATE USING PROTON RECOIL NEUTRON TELESCOPE
Authors: Ghodke Shobha , Sathian V , Singh Yashoda , Patel Tarun , Santra S 
Published: July 2020

Abstract
A single stage vacuum-type proton recoil neutron telescope (PRT) was used for accurate measurement of 14.57 MeV neutron fluence rate from an indigenously developed D-T neutron generator at Purnima, BARC. The telescope consists of a polyethylene radiator having 4 cm diameter and CsI (Tl) scintillation crystal having thickness 1.5 mm and 4 cm diameter separated by 20.5 cm kept in a vacuum chamber. The neutron detection efficiency of the telescope for 14.57 MeV neutrons was calculated analytically using n-p scattering cross section data from Evaluated Nuclear Data File VII and also evaluated using fluka simulation. The relativistic transformation of n-p differential scattering cross section from centre-of-mass to laboratory system was used for calculating the efficiency of PRT. The 14.57 MeV neutron fluence rate was also measured using copper foils. The comparison of fluence rate measured using PRT and copper foil activation techniques is presented in this paper. The total uncertainty in measurement using PRT and copper foil activation technique is found to be 3.93 and 6.97%, respectively.
Increase in ring width, vessel number and δ18O in olive trees infected with Xylella fastidiosa
Authors: Sabella Erika , Moretti Samuele , Gärtner Holger , Luvisi Andrea , De Bellis Luigi , Vergine Marzia , Saurer Matthias , Cherubini Paolo 
Published: July 2020

Abstract
Xylella fastidiosa (Xf) Wells, Raju et al., 1986 is a bacterium that causes plant diseases in the Americas. In Europe, it was first detected on the Salento Peninsula (Italy), where it was found to be associated with the olive quick decline syndrome. Here, we present the results of the first tree-ring study of infected and uninfected olive trees (Olea europaea L.) of two different cultivars, one resistant and one susceptible, to establish the effects induced by the spread of the pathogen inside the tree. Changes in wood anatomical characteristics, such as an increase in the number of vessels and in ring width, were observed in the infected plants of both the cultivars Cellina di Nardò (susceptible to Xf infection) and Leccino (resistant to Xf infection). Thus, whether infection affects the mortality of the tree or not, the tree shows a reaction to it. The presence of occlusions was detected in the wood of both 4-year-old branches and the tree stem core. As expected, the percentage of occluded vessels in the Xf-susceptible cultivar Cellina di Nardò was significantly higher than in the Xf-resistant cultivar Leccino. The δ 18O of the 4-year-old branches was significantly higher in infected trees of both cultivars than in noninfected trees, while no variations in δ 13C were observed. This suggests a reduction in leaf transpiration rates during infection and seems to be related to the occlusions observed in rings of the 4-year-old branches. Such occlusions can determine effects at leaf level that could influence stomatal activity. On the other hand, the significant increase in the number of vessels in infected trees could be related to the tree’s attempt to enhance water conductivity in response to the pathogen-induced vessel occlusions.
Innovative Bioactive Glass Fiber Technology Accelerates Wound Healing and Minimizes Costs: A Case Series
Authors: Buck Donald W. 
Published: July 2020

ABSTRACT

OBJECTIVE
To evaluate the efficacy and value of a novel borate-based bioactive glass fiber (BBGF) advanced wound matrix in the treatment of chronic wounds.

METHODS
Four patients with chronic wounds that had failed multiple prior treatments were identified and treated with the BBGF technology. Patient demographics, wound characteristics, and prior treatment history were obtained. Costs associated with prior treatments were estimated and recorded using available cost data.

RESULTS
The average wound duration prior to initiation of BBGF treatment was 391 days. All of the patients had a history of multiple failed interventions, including operative procedures, negative-pressure wound therapy, cellular and/or tissue-based products, dermal grafts, and synthetic wound matrices. Prior interventions resulted in an average estimated cost of $87,750 per patient. All of the patients achieved complete wound closure in an average of 55 days using BBGF treatment. Patients were treated with 3.3 applications of the BBGF product on average, with an average cost of $3,564. The use of the BBGF advanced wound matrix on initial presentation could have saved the healthcare system an average of $84,186 per patient and reduced wound duration by an average of 336 days.

CONCLUSIONS
The BBGF advanced wound matrix resulted in the healing of chronic wounds that had failed multiple prior interventions. In this series of challenging cases, BBGF accelerated healing while minimizing costs and improving patient outcomes. By offering an effective therapy at a low cost, BBGF has the potential to add significant value for both the healthcare system and the patient.
Type VII All-epiphyseal Fractures of the Lateral Malleolus and the Origin of Subfibular Ossicles
Authors: Gamble James G. 
Published: July 2020

Background:
A subfibular ossicle (SO), also known as an os subfibulare, is present in ∼1% of the general population. Two theories have been proposed to explain the origin of SOs: (1) as a failure of fusion of a secondary center of ossification; (2) as a posttraumatic sequela. This report offers prospective, longitudinal radiographic evidence for the formation of SOs as a posttraumatic sequela of type VII transepiphyseal fractures of the lateral malleolus in children.

Methods:
This Institutional Review Board–approved study was performed at a tertiary care pediatric hospital from March 2012 to April 2019. The study group included 37 children with a type VII fracture of the lateral malleolus and a minimum follow-up of 6 months.

Results:
Twenty-one children (57%) healed their fracture. Sixteen children (43%) went on to form SOs. The most common location for the fractures was the distal third of the epiphysis, and the most common fracture type forming SOs was a sleeve avulsion fracture. Four of the children forming SOs have had surgery to address pain and recurrent sprains.

Conclusions:
Overall, 43% of children who sustained a type VII fracture of the lateral malleolus went on to form SOs, giving support to the posttraumatic theory of origin. Sleeve avulsion fractures have the greatest chance of forming SOs. So far, 4 of the 16 children forming SOs have undergone surgery for ankle pain and recurrent sprains.

Level of Evidence:
Level II.
Indications of next-generation sequencing in non-Hodgkin's lymphoma
Authors: Heimann Pierre , Dewispelaere Laurent 
Published: July 2020

Purpose of review
In this study, we will give an overview on the current and foreseeable indications of next-generation sequencing (NGS)-based technologies for the diagnosis, prognostic assessment and decision of individualized treatment strategy in lymphomas.

Recent findings
Recent NGS-based studies have offered a comprehensive knowledge of the genetic landscapes featuring B-cell and T-cell lymphomas, with identification of genomic biomarkers useful for a better subclassification and, therefore, for a more accurate diagnosis. NGS analyses in lymphoma have also unveiled recurrent somatic mutations representing novel potential therapeutic targets or underlying drug resistance, and paved the way for tailor-made medicine. High throughput sequencing methods may also identify lymphoma-specific genetic aberrations in circulating tumoral DNA (liquid biopsy) obtained from blood samples. This suggests the possibility of performing minimally invasive diagnosis and real-time monitoring, with early detection of relapse and possibility of response-adapted therapy approaches.

Summary
NGS analyses should be included shortly in the diagnostic work up of lymphomas. Applying NGS to liquid biopsy at diagnosis and during follow up of lymphoma patients will be a significant breakthrough towards precision medicine.