bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinic-pathological aspect of gastro-intestinal stromal tumors at tertiary care Hospital India
Authors: Subramanian Sankar , Sandhu Amamndeep Sing , Balu Jagan , Suresh P 
Published: October 2019

AbstractBackground This study defines the disease profile in south Indian population and determine the clinic-pathological aspects of Gastro-Intestinal Stromal Tumors.Method In this prospective study patients diagnosed of gastrointestinal stromal tumors were taken thorough clinical examination and a database of Anthropometric details and clinical details were analyzed. Pathological data included tumor size, presence or absence necrosis, mitotic counts, immunohistochemistry for CD-117, CD-34.Results There were 44 patients with confirmed diagnosis of gastro-intestinal stromal tumor. The highest incidence was found in the 6th decade. The most common symptoms were abdominal pain and gastrointestinal bleed. Stomach was most frequent site for gastro-intestinal stromal tumors. Immunochemistry for CD-117 was positive in 93.18% cases. Majority of tumors (79.5%) had pure spindle cell morphology and mitotic activity showed that 34% of the GISTs were of the high risk group. Forty two patients were suggestive of surgery as the primary treatment after presentation.Conclusion Abdominal pain was the most common presenting complaint. Majority of the tumors aroused from the stomach. The majority of the tumors had pure spindle cell morphology and 93% of the tumors were CD-117 positive. A significant relationship between tumor size, tumor necrosis and mitotic activity with large tumors having necrosis and high mitotic rate having high risk of malignancy, was observed. Surgical resection is considered mainstay of treatment of gastro-intestinal stromal tumor. Imatinib therapy should be given to patients in moderate to severe risk categories.
Observed and Modeled Seasonal Air Quality and Respiratory Health in Senegal During 2015 and 2016
Authors: Toure Nafissatou Oumar , Gueye Ndeye Ramatoulaye Diagne , Mbow‐Diokhane Aminata , Jenkins Gregory S. , Li Maggie , Drame Mamadou S. , Coker Karen Adjoa Ronke , Thiam Khady 
Published: October 2019

AbstractIn this work, we use existing particulate matter (PM) data from Dakar, Senegal, satellite aerosol optical depth (AOD) and the Weather Research and Forecasting (WRF) model to evaluate the role of dust transport from the Sahara and PM concentrations and exposure into other administrative districts of Senegal during 2015 and 2016. We also use data from the Ministry of Health to examine spatial and temporal patterns of acute respiratory infections, asthma, bronchitis, and tuberculosis across Senegal with an emphasis on Northern Hemisphere winter December–February, when air quality is poor, and June–August when there is an improvement in air quality. Measurements in Dakar, Senegal, suggest hazardous PM10 concentrations associated with Saharan dust storms but lower PM10 concentrations during the summer. The WRF dust simulations show a similar temporal pattern to the observations in Dakar, Senegal, with notable biases. However, the WRF model suggests that the highest dust concentrations are found across the northern half of Senegal during the winter season where there are no currently PM measurements. Health data during 2015–2016 show the highest prevalence of asthma and bronchitis in Dakar, Senegal, suggesting that other sources of air pollution are important. Acute respiratory infection is prevalent throughout the country with the high prevalence found in rural zones, for children between 12 and 59 months. All measures including real‐time monitoring, air quality forecast, and communication should be used to protect the public from potentially hazardous environmental conditions during the winter season.
Oil Spills and Human Health: Contributions of the Gulf of Mexico Research Initiative
Authors: Eklund Ruth L. , Knapp Landon C. , Sandifer Paul A. , Colwell Rita C. 
Published: October 2019

AbstractThe Gulf of Mexico Research Initiative (GoMRI) was established in 2010 with $500 million in funding provided by British Petroleum over a 10‐year period to support research on the impacts of the Deepwater Horizon oil spill and recovery. Contributions of the GoMRI program to date focused on human health are presented in more than 32 peer‐reviewed papers published between 2011 and May 2019. Primary findings from review of these papers are (i) the large quantity of dispersants used in the oil cleanup have been associated with human health concerns, including through obesogenicity, toxicity, and illnesses from aerosolization of the agents; (ii) oil contamination has been associated with potential for increases in harmful algal blooms and numbers of pathogenic Vibrio bacteria in oil‐impacted waters; and (iii) members of Gulf communities who are heavily reliant upon natural resources for their livelihoods were found to be vulnerable to high levels of life disruptions and institutional distrust. Positive correlations include a finding that a high level of community attachment was beneficial for recovery. Actions taken to improve disaster response and reduce stress‐associated health effects could lessen negative impacts of similar disasters in the future. Furthermore, GoMRI has supported annual conferences beginning in 2013 at which informative human health‐related presentations have been made. Based on this review, it is recommended that the Oil Pollution Act of 1990 be updated to include enhanced funding for oil spill impacts to human health.
Deciphering channel networks from aeromagnetic potential field data: the case of the North Sea Quaternary tunnel valleys
Authors: Brahimi S , Le Maire P , Ghienne J F , Munschy M 
Published: October 2019

Summary
High-resolution magnetic data and potential field methods have been used to perform a detailed analysis of networks of late Quaternary subglacially-cut tunnel valleys (central Viking Graben, Norwegian sector of the North Sea). High-frequency, ribbon-like, sinuous, paired magnetic anomalies interpreted to be the signature of tunnel valleys are identified. Such magnetic anomalies have 1 to 8 nT amplitudes and reflect a magnetic susceptibility contrast between valley infills and the host sediments. Fractional vertical derivative and horizontal gradient transforms provide the best control on the accurately delineation of tunnel valleys by plotting automatically the extrema. The 2D forward modelling is a very effective approach to determinating the geometric parameters and magnetic susceptibility of the modeled valleys. It allows to determine the finite-width flat horizontal thin geometry as the most appropriate simple geometry to simulate the magnetic anomaly linked to a channel structure. The application of Euler deconvolution using complex algebra allows to substantiate the structural index (n = 1.5) for simple palaeovalley geometries and to determine fair valley depth estimates.
Opening the ‘implementation black-box’ of the user fee exemption policy for caesarean section in Benin: a realist evaluation
Authors: Dossou Jean-Paul , De Brouwere Vincent , Van Belle Sara , Marchal Bruno 
Published: October 2019

AbstractTo improve access to maternal health services, Benin introduced in 2009 a user fee exemption policy for caesarean sections. Similar to other low- and middle-income countries, its implementation showed mixed results. Our study aimed at understanding why and in which circumstances the implementation of this policy in hospitals succeeded or failed. We adopted the realist evaluation approach and tested the initial programme theory through a multiple embedded case study design. We selected two hospitals with contrastive outcomes. We used data from 52 semi-structured interviews, a patient exit survey, a costing study of caesarean section and an analysis of financial flows. In the analysis, we used the intervention-context-actor-mechanism-outcome configuration heuristic. We identified two main causal pathways. First, in the state-owned hospital, which has a public-oriented but administrative management system, and where citizens demand accountability through various channels, the implementation process was effective. In the non-state-owned hospital, managers were guided by organizational financial interests more than by the inherent social value of the policy, there was a perceived lack of enforcement and the implementation was poor. We found that trust, perceived coercion, adherence to policy goals, perceived financial incentives and fairness in their allocation drive compliance, persuasion, positive responses to incentives and self-efficacy at the operational level to generate the policy implementation outcomes. Compliance with the policy depended on enforcement by hierarchical authority and bottom-up pressure. Persuasion depended on the alignment of the policy with personal and organizational values. Incentives may determine the adoption if they influence the local stakeholder’s revenue are trustworthy and perceived as fairly allocated. Failure to anticipate the differential responses of implementers will prevent the proper implementation of user fee exemption policies and similar universal health coverage reforms.
Food insecurity and the extremes of childhood weight: defining windows of vulnerability
Authors: Zhu Yeyi , Mangini Lauren D , Hayward Mark D , Forman Michele R 
Published: October 2019

Abstract

Background
Weight extremes and food insecurity (FIS) represent public-health challenges, yet their associations in childhood remain unclear. We aimed to investigate the longitudinal time-specific relationship between FIS and risk of overweight/obesity and underweight in kindergarten through 8th grade.

Methods
In the prospective Early Childhood Longitudinal Study–Kindergarten Cohort (1998–2007) of 6368 children, household FIS was assessed by the validated US Household Food Security Survey Module in kindergarten, 3rd, 5th and 8th grades. Multivariable linear-regression and Poisson-regression models were computed.

Results
Compared with children experiencing food security (FS), children exposed to FIS in 5th grade had 0.19 [95% confidence interval (CI): 0.07–0.30] and 0.17 (0.06–0.27) higher body mass index z-score (BMIZ) in the 5th and 8th grades, respectively, whereas FIS in the 8th grade was associated with a 0.29 (0.19–0.40) higher BMIZ at the same wave, after adjusting for covariates and FIS at earlier waves. Children with FIS vs FS had 27% (relative risk: 1.27, 95% CI: 1.07–1.51), 21% (1.21, 1.08–1.35) and 28% (1.28, 1.07–1.53) higher risk of overweight/obesity in the 3rd, 5th and 8th grades, respectively, adjusting for covariates and FIS at prior wave(s). Children with FIS vs FS in kindergarten had a 2.76-fold (1.22–6.25) higher risk of underweight in the 8th grade.

Conclusions
Proximal exposure to household FIS was associated with a higher risk of overweight/obesity in the 3rd, 5th and 8th grades. FIS in kindergarten was associated with a risk of underweight in the 8th grade. Thus, FIS coexists in weight extremes during vulnerable early-life windows in the USA, similarly to the global burden of FIS.
On the Number of Products Which Form Perfect Powers and Discriminants of Multiquadratic Extensions
Authors: de la Bretèche Régis , Kurlberg Pär , Shparlinski Igor E 
Published: October 2019

Abstract
We study some counting questions concerning products of positive integers $u_1, \ldots , u_n$, which form a nonzero perfect square, or more generally, a perfect $k$-th power. We obtain an asymptotic formula for the number of such integers of bounded size and in particular improve and generalize a result of D. I. Tolev (2011). We also use similar ideas to count the discriminants of number fields that are multiquadratic extensions of ${\mathbb{Q}}$ and improve and generalize a result of N. Rome (2017).
Does High-Frequency Social Media Data Improve Forecasts of Low-Frequency Consumer Confidence Measures?
Authors: Lehrer Steven , Xie Tian , Zeng Tao 
Published: October 2019

Abstract
Social media data present challenges for forecasters since one must convert text into data and deal with issues related to these measures being collected at different frequencies and volumes than traditional financial data. In this article, we use a deep learning algorithm to measure sentiment within Twitter messages on an hourly basis and introduce a new method to undertake mixed data sampling (MIDAS) that allows for a weaker discounting of historical data that is well-suited for this new data source. To evaluate the performance of approach relative to alternative MIDAS strategies, we conduct an out of sample forecasting exercise for the consumer confidence index with both traditional econometric strategies and machine learning algorithms. Irrespective of the estimator used to conduct forecasts, our results show that (i) including consumer sentiment measures from Twitter greatly improves forecast accuracy and (ii) there are substantial gains from our proposed MIDAS procedure relative to common alternatives.
hypercalcaemia due to a calcitriol-producing neuroendocrine tumour
Authors: van Lierop Antoon H , Bisschop Peter H , Boelen Anita , van Eeden Susanne , Engelman Anton F , Nieveen van Dijkum Elisabeth J , Klümpen Heinz-Josef 
Published: October 2019

Abstract
In this case report, we describe a 40-year-old patient with a large grade 2 pancreatic neuroendocrine tumour (pNET) with spleen metastasis. Albeit radical resection, he developed liver metastasis after 2 years, for which he underwent radio frequency ablation and embolization, and was treated successfully with different subsequent lines of systemic therapy. Eight years after the initial diagnosis, he was admitted for symptomatic and refractory hypercalcaemia, due to calcitriol synthesis by the liver metastasis. After tumour load reduction by hemihepatectomy, there was an initial normalization of hypercalcaemia, until it recurred after 18 months. In this period, the liver metastasis had progressed despite chemo- and immunotherapy. Patient underwent an additional extend hemihepatectomy, from which he recovered well with normalization of calcium levels. This case illustrates the hormonal plasticity of pNETs and shows how prolonged survival can be achieved for metastatic pNET by multimodality approach.
Metal-enriched galaxies in the first ∼1 billion years: evidence of a smooth metallicity evolution at z ∼ 5
Authors: Poudel Suraj , Kulkarni Varsha P , Cashman Frances H , Frye Brenda , Péroux Céline , Rahmani Hadi , Quiret Samuel 
Published: October 2019

ABSTRACT
We present seven new abundance measurements of the elements O, C, and Si at z &gt; 4.5, doubling the existing sample of weakly depleted elements in gas-rich galaxies, in order to constrain the first ∼1 billion years of cosmic metal evolution. These measurements are based on quasar spectra of damped Lyman α absorbers (DLAs) and sub-DLAs obtained with the Magellan Inamori Kyocera Echelle (MIKE) and Magellan Echellette (MagE) spectrographs on Magellan-South, and the X-Shooter spectrograph on the Very Large Telescope. We combine these new measurements with those drawn from the literature to estimate the $N_{\rm H\, {\small I}}$-weighted binned mean metallicity of −1.51 ± 0.18 at z = 4.8. This metallicity value is in excellent agreement with the prediction from lower redshift DLAs, supporting the interpretation that the metallicity evolution is smooth at z ∼ 5, rather than showing a sudden decline at z &gt; 4.7. Furthermore, the metallicity evolution trends for the DLAs and sub-DLAs are similar within our uncertainties. We also find that the [C/O] ratios for z ∼ 5 DLAs are consistent with those of the very metal-poor DLAs. Additionally, using [C/O] and [Si/O] to constrain the nucleosynthesis models, we estimate that the probability distributions of the progenitor star masses for three relatively metal-poor DLAs are centred around 12–17 M⊙. Finally, the z ∼ 5 absorbers show a different metallicity–velocity dispersion relation than lower redshift DLAs, suggesting that they may be tracing a different population of galaxies.
PPR20 Is Required for the cis-Splicing of Mitochondrial nad2 Intron 3 and Seed Development in Maize
Authors: Yang Yan-Zhuo , Ding Shuo , Wang Yong , Wang Hong-Chun , Liu Xin-Yuan , Sun Feng , Xu Chunhui , Liu Baohui , Tan Bao-Cai 
Published: October 2019

AbstractPentatricopeptide repeat (PPR) proteins are helical repeat RNA-binding proteins that function in RNA processing by conferring sequence-specific RNA-binding activity. Owing to the lethality of PPR mutants, functions of many PPR proteins remain obscure. In this study, we report the function of PPR20 in intron splicing in mitochondria and its role in maize seed development. PPR20 is a P-type PPR protein targeted to mitochondria. The ppr20 mutants display slow embryo and endosperm development. Null mutation of PPR20 severely reduces the cis-splicing of mitochondrial nad2 intron 3, resulting in reduction in the assembly and activity of mitochondrial complex I. The ppr20-35 allele with a Mu insertion in the N-terminal region shows a much weaker phenotype. Molecular analyses revealed that the mutant produces a truncated transcript, coding for PPR20ΔN120 lacking the N-terminal 120 amino acids. Subcellular localization revealed that PPR20ΔN120:GFP is able to target to mitochondria as well, suggesting the sequence diversity of the mitochondrial targeting peptides. Another mutant zm_mterf15 was also found to be impaired in the splicing of mitochondrial nad2 intron 3. Further analyses are required to identify the exact function of PPR20 and Zm_mTERF15 in the splicing of nad2 intron 3.
Trauma exposure, mental health and tobacco use among vulnerable Syrian refugee youth in Jordan
Authors: Kheirallah Khalid A , Cobb Caroline O , Alsulaiman Jomana W , Alzoubi Abdallah , Hoetger Cosima , Kliewer Wendy , Mzayek Fawaz 
Published: October 2019

Abstract

Background
Little is known about tobacco use among youth exposed to armed conflicts, or the influence of trauma on tobacco use in this context. This study examined patterns of smoking by tobacco product and gender among Syrian refugee youth living in host communities in Jordan and assessed the associations of post-traumatic stress disorder (PTSD) and depression symptoms, trauma exposure and social support with current smoking status in boys and girls.

Methods
Syrian refugee students (mean [standard deviation] age = 14.9 [1.33] years) were identified through the public school system. Data were collected using an online Arabic questionnaire that included questions about demographics, trauma exposure, current smoking (cigarette and waterpipe), PTSD, depression and perceived social support. Logistic regression was used to assess the adjusted effects of independent variables on current smoking status.

Results
One in 7 boys and one in 14 girls were current smokers, with boys reporting greater tobacco use than girls. Among boys, current smokers reported significantly higher family member loss and lower perceived family social support than nonsmokers; among girls, current smokers also reported significantly higher family member loss as well as greater PTSD symptoms and lower perceived significant other/special person social support.

Conclusions
Tobacco use is established among this vulnerable group. The findings highlight the potential role of psychosocial support for tobacco prevention and cessation strategies.
ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus
Authors: Parodis Ioannis , Gokaraju Sirisha , Zickert Agneta , Vanarsa Kamala , Zhang Ting , Habazi Deena , Botto João , Serdoura Alves Clara , Giannopoulos Panagiotis , Larsson Anders , Svenungsson Elisabet , Gunnarsson Iva , Mohan Chandra 
Published: October 2019

Abstract

Objectives
We investigated the cell adhesion molecules (CAMs) Vascular CAM 1 (VCAM-1) and Activated Leucocyte CAM (ALCAM) as urinary biomarkers in SLE patients with and without renal involvement.

Methods
Female SLE patients (n = 111) and non-SLE population-based controls (n = 99) were enrolled. We measured renal activity using the renal domain of the BILAG index and urine (U) and plasma (P) concentrations of soluble (s)VCAM 1 and U-sALCAM using ELISA. U-sCAM levels were next corrected by U-creatinine.

Results
U-sVCAM-1/creatinine and U-sALCAM/creatinine ratios were higher in SLE patients vs non-SLE controls (P &lt; 0.001 for both), as well as in patients with active/low-active (BILAG A–C; n = 11) vs quiescent (BILAG D; n = 19) LN (P = 0.023 and P = 0.001, respectively). U-sALCAM/creatinine but not U-sVCAM-1/creatinine ratios were higher in patients with nephritis history (BILAG A–D; n = 30) vs non-renal SLE (BILAG E; n = 79) (P = 0.014). Patients with baseline U-sVCAM-1/creatinine ratios ≥75th percentile showed a 23-fold increased risk of a deterioration in estimated glomerular filtration rate by ≥25% during a 10-year follow-up (odds ratio: 22.9; 95% CI: 2.8, 189.2; P = 0.004); this association remained significant after adjustments for age, disease duration and organ damage. Traditional markers including anti-dsDNA antibodies did not predict this outcome.

Conclusion
While high U-sVCAM-1 levels appear to reflect SLE disease activity, sALCAM might have particular importance in renal SLE. Both U-sVCAM-1 and U-sALCAM showed ability to distinguish SLE patients with active renal involvement from patients with quiescent or no prior nephritis. High U-sVCAM-1 levels may indicate patients at increased risk for long-term renal function loss.
Management of rheumatic complications of immune checkpoint inhibitor therapy – an oncological perspective
Authors: Steven Neil M , Fisher Benjamin A 
Published: October 2019

AbstractImmune checkpoint inhibitors (CPIs) are an effective treatment for many cancers but cause diverse immune-related adverse events (IrAEs). Rheumatological IrAEs include arthralgia, arthritis, tenosynovitis, myositis, polymyalgia rheumatica and sicca syndrome. CPI use can unmask RA as well as causing flares of prior autoimmune or connective tissue disease. Oncologists categorize and grade IrAEs using the Common Terminology Criteria for Adverse Events and manage them according to international guidelines. However, rheumatological events are unfamiliar territory: oncologists need to work with rheumatologists to elicit and assess symptoms, signs, results of imaging and autoantibody testing and to determine the use of steroids and DMARDs. Myositis may overlap with myasthenic crisis and myocarditis and can be life-threatening. Treatment should be offered on balance of risk and benefit, including whether to continue CPI treatment and recognizing the uncertainty over whether glucocorticoids and DMARDs might compromise cancer control.