bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Vulnerability and Resilience of African Food Systems, Food Security, and Nutrition in the Context of the COVID-19 Pandemic
Authors: Moseley William G. , Battersby Jane 
Published: August 2020

Abstract:As the COVID-19 pandemic rages across the globe, ebbing and flowing from one region to the next, new infections and deaths continue to rise (Johns Hopkins 2020). Some of the first documented cases in Africa occurred in areas frequented by foreign tourists. Early on, the disease also circulated among Africa’s jet-setting political classes that had spent time in other regions of the world with higher infection rates. Since then, infections have taken off in the continent’s urban areas that are better connected globally via trade and travel. From there, it has spread to smaller cities, towns, and then to rural areas, a process known as hierarchical diffusion (Moseley 2020a). Unfortunately, there is another scourge that accompanies COVID-19, and that is a global hunger pandemic. In April 2020, the director of the World Food Programme warned that an additional 130 million people could be pushed to the brink of starvation by the end of 2020 because of the coronavirus. This comes on top of the 821 million people in the world who are already food insecure (Khorsandi 2020). Increasingly, scholars of food security, food systems, and poverty have come to realize that the hunger and malnutrition associated with COVID-19 may actually kill or debilitate more people than the disease itself, especially in regions of the world with weaker social safety nets (Fanzo 2020; HLPE 2020a, 2020b; UN 2020).
Postimpact Evolution of the Southern Hale Crater Ejecta, Mars
Authors: Collins‐May J. L. , Carr J. R. , Balme M. R. , Ross N. , Russell A. J. , Brough S. , Gallagher C. 
Published: August 2020

AbstractAs one of the youngest large (>100 km wide) impacts on Mars, Hale crater offers a unique opportunity to observe well‐preserved deposits of Mars' former interior. We utilize visible imagery (Context Camera [CTX] and High Resolution Imaging Science Experiment [HiRISE]) and elevation data (Mars Orbiter Laser Altimeter [MOLA], High Resolution Stereo Camera [HRSC], and HiRISE stereo pairs) to examine the region south of Hale crater, which contains the greatest density of landforms caused by with the impact. Linear depressions, mounds, and polygons indicate that the ejecta material contained volatiles and underwent substantial postimpact geomorphic evolution after it was emplaced. Ejecta landform formation was facilitated by volatiles, likely water ice displaced from the subsurface during the impact, contained within the material. We suggest that the ejecta flowed into valleys where it acted in a manner similar to terrestrial debris flows, leaving mounds, high‐standing deposits, lobate flow margins, and fan structures. Continued flow and settling of the ejecta then caused deposit dewatering, producing networks of linear depressions, particularly in places where the flows of ejecta were constricted. However, these landforms are not present everywhere, and their formation was likely influenced by topography. This work highlights that, while volatiles were present over much of Hale crater's ejecta blanket, the surface expression of them is spatially variable on local and regional scales.
Role of Bottom‐Side Density Gradient in the Development of Equatorial Plasma Bubble/Spread F Irregularities: Solar Minimum and Maximum Conditions
Authors: Abdu M. A. , Kherani E. A. , Sousasantos J. 
Published: August 2020

AbstractFrom the analysis of Digisonde data over Brazilian equatorial and low‐latitude sites, we investigate the relative importance of the different parameters driving the generation of rising bubble‐type and bottom‐type spread F (SF) irregularities. Data for the complete month of October 2001, a solar maximum epoch (F10.7 = 210), and that of October 2008, an extended solar minimum period (F10.7 = 70), are analyzed to examine the SF intensity and occurrence rate as a function of the evening prereversal vertical drift velocity and the corresponding F layer heights and the bottom‐side density gradient. While the SF at the equatorial site is indicative of both the bottom‐side irregularities and rising bubbles, the SF at the low latitude represents exclusively the latter. Comparison of the results, from the two epochs, reveals a large decrease in the intensity and occurrence rate of plasma bubbles, with a decrease in solar flux. But a notable increase in these characteristics is observed in the case of bottom‐side SF. It is found that a larger (steeper) density gradient of the F layer bottom side that exists in the low solar flux condition is responsible for an enhanced Raleigh‐Taylor instability growth, counterbalancing a reduction in this rate that may arise from a smaller prereversal vertical drift and lower layer height that also characterize the low solar flux condition. Thus, the role of the bottom‐side density gradient in the ESF instability growth has been identified for the first time in terms of its ability to explain the contrasting irregularity features as observed during solar flux maximum and minimum years.
Scale Sizes of Magnetosheath Jets
Authors: Plaschke Ferdinand , Hietala Heli , Vörös Zoltan 
Published: August 2020

AbstractMagnetosheath jets are plasma entities that feature a significantly enhanced dynamic pressure with respect to the ambient plasma. They occur more often downstream of the quasi‐parallel bow shock. Jets can propagate through the entire magnetosheath and impact on the magnetopause. We reanalyze multi‐spacecraft data from the Time History of Events and Macroscale Interactions during Substorms (THEMIS) mission to obtain the first unbiased distributions of scale sizes of the jets, in the directions parallel and perpendicular to their propagation direction. These distributions are log‐normal; they fit well to the observations. We argue that jet scales should be log‐normally distributed as they should result from multiplicative processes in the foreshock and in the magnetosheath. We find that typical jet scales are on the order of 0.1 Earth radii (RE), one order of magnitude smaller than previously reported. Median scale sizes of 0.12 RE and 0.15 RE in the perpendicular and parallel directions are obtained. The small scales may be related to the substructure of Short Large Amplitude Magnetic Structures (SLAMS) in the foreshock, or to the break up of larger jets within the magnetosheath. Use of the log‐normal distributions also allows for an analysis of impact rates of small‐scale jets: While previous results on large jets hitting the magnetopause several times per hour remain largely unchanged, we now find that hundreds to thousands of mostly small‐scale jets could potentially impact the dayside magnetopause every hour.
First Analysis of Earth's Stratospheric γ‐Ray Emission in Geographical Coordinates With Fermi LAT
Authors: Madlee S. , Mitthumsiri W. , Ruffolo D. , Digel S. , Nuntiyakul W. 
Published: August 2020

AbstractFrom low‐Earth orbit, the Earth is an extremely bright γ‐ray source compared to distant astrophysical objects. The high‐energy γ‐ray emission, from the Earth's upper atmosphere, is produced by the interactions between cosmic rays (CRs) and air molecules. As CRs are predominantly charged particles, the geomagnetic field acts as a spectrometer, forbidding CRs below a certain energy to arrive and interact with the atmosphere at a given geomagnetic location from a given direction. We use photon data between 0.2 and 20 GeV as observed by the Fermi Large Area Telescope (LAT) to create, for the first time, stratospheric γ‐ray emission maps of the Earth in the geographical coordinate system, for different viewing directions from LAT altitude. These maps confirm a strong association between measured γ‐ray fluxes and geomagnetic cutoffs for CRs. We also report the spectrum of the Earth's stratospheric γ‐ray emission in cardinal directions and use the geomagnetic spectrometer effect to infer the atmosphere's yield function of γ rays per incoming CR proton as a function of CR rigidity at the altitude of the Fermi spacecraft. This work is relevant to the study of near‐Earth radiation exposure for astronauts and spacecraft, modeling the geomagnetic field, and CR‐air interactions.
Differential Sensitivity of a Symbiont‐Bearing Foraminifer to Seawater Carbonate Chemistry in a Decoupled DIC‐pH Experiment
Authors: Oron Shai , Evans David , Abramovich Sigal , Almogi‐Labin Ahuva , Erez Jonathan 
Published: August 2020

AbstractLarger benthic foraminifera (LBF) are unicellular eukaryotic calcifying organisms and an important component of tropical and subtropical modern and ancient oceanic ecosystems. They are major calcium carbonate producers and important contributors to primary production due to the photosynthetic activity of their symbiotic algae. Studies investigating the response of LBF to seawater carbonate chemistry changes are therefore essential for understanding the impact of climate changes and ocean acidification (OA) on shallow marine ecosystems. In this study, calcification, respiration, and photosynthesis of the widespread diatom‐bearing LBF Operculina ammonoides were measured in laboratory experiments that included manipulation of carbonate chemistry parameters. pH was altered while keeping dissolved inorganic carbon (DIC) constant, and DIC was altered while keeping pH constant. The results show clear vulnerability of O. ammonoides to low pH and CO32− under constant DIC conditions, and no increased photosynthesis or calcification under high DIC concentrations. Our results call into question previous hypotheses, suggesting that mechanisms such as the degree of cellular control on calcification site pH/DIC and/or enhanced symbiont photosynthesis in response to OA may render the hyaline (perforate and calcitic‐radial) LBF to be less responsive to OA than porcelaneous LBF. In addition, manipulating DIC did not affect calcification when pH was close to present seawater levels in a model encompassing the total population size range. In contrast, larger individuals (>1,200 μm, >1 mg) were sensitive to changes in DIC, a phenomenon we attribute to their physiological requirement to concentrate large quantities of DIC for their calcification process.
Impact of Inner Heliospheric Boundary Conditions on Solar Wind Predictions at Earth
Authors: Gonzi Siegfried , Weinzierl M. , Bocquet F.‐X. , Bisi M. M. , Odstrcil D. , Jackson B. V. , Yeates A. R. , Jackson D. R. , Henney C. J. , Nick Arge C. 
Published: August 2020

AbstractPredictions of the physical parameters of the solar wind at Earth are at the core of operational space weather forecasts. Such predictions typically use line‐of‐sight observations of the photospheric magnetic field to drive a heliospheric model. The models Wang‐Sheeley‐Arge (WSA) and ENLIL for the transport in the heliosphere are commonly used for these respective tasks. Here we analyze the impact of replacing the potential field coronal boundary conditions from WSA with two alternative approaches. The first approach uses a more realistic nonpotential rather than potential approach, based on the Durham Magneto Frictional Code (DUMFRIC) model. In the second approach the ENLIL inner boundary conditions are based on Inter Planetary Scintillation observations (IPS). We compare predicted solar wind speed, plasma density, and magnetic field magnitude with observations from the WIND spacecraft for two 6‐month intervals in 2014 and 2016. Results show that all models tested produce fairly similar output when compared to the observed time series. This is not only reflected in fairly low correlation coefficients (<0.3) but also large biases. For example, for solar wind speed some models have average biases of more than 150 km/s. On a positive note, the choice of coronal magnetic field model has a clear influence on the model results when compared to the other models in this study. Simulations driven by IPS data have a high success rate with regard to detection of the high speed solar wind. Our results also indicate that model forecasts do not degrade for longer forecast times.
Progress against childhood and adolescent acute lymphoblastic leukaemia in the Netherlands, 1990–2015
Authors: Reedijk Ardine M. J. , Coebergh Jan Willem W. , de Groot-Kruseman Hester A. , van der Sluis Inge M. , Kremer Leontien C. , Karim-Kos Henrike E. , Pieters Rob 
Published: August 2020

AbstractWe assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age group and ALL subtype. Between 1990 and 2015, 2997 ALL patients were diagnosed, i.e. 115 patients (range 87–147) per year. Overall incidence remained stable at 37 per million children, despite increases for B-cell precursor ALL (BCP-ALL) at age 10–14 years (AAPC + 1.4%, p = 0.04) and T-cell ALL at 15–17 years (AAPC + 3.7%, p = 0.01). Five-year survival increased from 80% in 1990–94 to 91% in 2010–15 (p < 0.01). Mortality decreased by 4% annually (p < 0.01). Patients 15–17 years were increasingly treated in a paediatric oncology centre, from 35% in 1990–94 to 87% in 2010–15 and experienced a 70% reduction of risk of death compared to those treated outside such a centre (p < 0.01). Significant progress against childhood ALL has been made in the Netherlands, visible by improved survival rates coinciding with declining mortality rates. These outcomes were accompanied by stable incidence rates, despite increases for BCP-ALL at age 10–14 years and T-cell ALL at age 15–17 years.
Aldosterone from endometrial glands is benefit for human decidualization
Authors: Li Shu-Yun , Song Zhuo , Yan Ya-Ping , Li Bo , Song Min-Jie , Liu Yue-Fang , Yang Zhen-Shan , Li Meng-Yuan , Liu Ai-Xia , Quan Song , Yang Zeng-Ming 
Published: August 2020

AbstractLocal renin-angiotensin system (RAS) in female reproductive system is involved in many physiological and pathological processes, such as follicular development, ovarian angiogenesis, ovarian, and endometrial cancer progress. However, studies on the functional relevance of RAS in human endometrium are limited, especially for renin-angiotensin-aldosterone system (RAAS). In this study, we defined the location of RAS components in human endometrium. We found that angiotensin II type-1 receptor (AT1R) and aldosterone synthase (CYP11B2), major components of RAAS, are specifically expressed in endometrial gland during mid-secretory phase. Aldosterone receptor, mineralocorticoid receptor (MR), is elevated in stroma in mid-secretory endometrium. In vitro, MR is also activated by aldosterone during decidualization. Activated MR initiates LKB1 expression, followed by phosphorylating of AMPK that stimulates PDK4 expression. The impact of PDK4 on decidualization is independent on PDHE1α inactivation. Based on co-immunoprecipitation, PDK4 interacts with p-CREB to prevent its ubiquitination for facilitating decidualization via FOXO1. Restrain of MR activation interrupts LKB1/p-AMPK/PDK4/p-CREB/FOXO1 pathway induced by aldosterone, indicating that aldosterone action on decidualization is mainly dependent on MR stimulation. Aldosterone biosynthesized in endometrial gland during mid-secretory phase promotes decidualization via activating MR/LKB1/p-AMPK/PDK4/p-CREB/FOXO1 signaling pathway. This study provides the valuable information for understanding the underlying mechanism during decidualization.
LncRNA CRNDE facilitates epigenetic suppression of CELF2 and LATS2 to promote proliferation, migration and chemoresistance in hepatocellular carcinoma
Authors: Xie Shu-Cai , Zhang Jian-Quan , Jiang Xi-Li , Hua Yong-Yong , Xie Shao-Wei , Qin Ye-Ang , Yang Yi-Jun 
Published: August 2020

AbstractOur study aimed to investigate the expression, functional significance, and related mechanism of long noncoding RNA CRNDE (colorectal neoplasia differentially expressed) in hepatocellular carcinoma (HCC) pathogenesis. The resulted revealed that CRNDE was significantly overexpressed in HCC tissues and cell lines, and was statistically correlated with poor clinical outcome. CRNDE knockdown markedly decreased HCC cell proliferation, migration, and chemoresistance. In addition, in vivo experiments confirmed the suppressive effect of CRNDE knockdown on HCC progression. Mechanically, CRNDE directly bound to EZH2 (enhancer of zeste homolog), SUZ12 (suppressor of zeste 12), SUV39H1, and mediated their inhibition of tumor suppressor genes, including CUGBP Elav-like family member 2 (CELF2) and large tumor suppressor 2 (LATS2). CELF2 exerted tumor suppressive effect in HCC and was involved in CRNDE-mediated oncogenic effect. In addition, the oncogenic effects of CRNDE on HCC proliferation, migration and tumorigenesis, as well as its inhibition of Hippo pathway were abolished by LATS2 overexpression. Together, our work demonstrated the importance of CRNDE in HCC progression and elucidated the underlying molecular mechanisms. These findings provided new insights into HCC pathogenesis and chemoresistance mediated by CRNDE.
The Laetiporus polyketide synthase LpaA produces a series of antifungal polyenes
Authors: Seibold Paula Sophie , Lenz Claudius , Gressler Markus , Hoffmeister Dirk 
Published: August 2020

AbstractThe conspicuous bright golden to orange-reddish coloration of species of the basidiomycete genus Laetiporus is a hallmark feature of their fruiting bodies, known among mushroom hunters as the “chicken of the woods”. This report describes the identification of an eight-domain mono-modular highly reducing polyketide synthase as sole enzyme necessary for laetiporic acid biosynthesis. Heterologous pathway reconstitution in both Aspergillus nidulans and Aspergillus niger verified that LpaA functions as a multi-chain length polyene synthase, which produces a cocktail of laetiporic acids with a methyl-branched C26–C32 main chain. Laetiporic acids show a marked antifungal activity on Aspergillus protoplasts. Given the multiple products of a single biosynthesis enzyme, our work underscores the diversity-oriented character of basidiomycete natural product biosynthesis.
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
Authors: Agarwal Devika , Sandor Cynthia , Volpato Viola , Caffrey Tara M. , Monzón-Sandoval Jimena , Bowden Rory , Alegre-Abarrategui Javier , Wade-Martins Richard , Webber Caleb 
Published: August 2020

AbstractWe describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways. We identify a distinct cell type association between PD risk and oligodendrocyte-specific gene expression. Unlike Alzheimer’s disease (AD), we find no association between PD risk and microglia or astrocytes, suggesting that neuroinflammation plays a less causal role in PD than AD. Beyond PD, we find associations between SN DaNs and GABAergic neuron gene expression and multiple neuropsychiatric disorders. Conditional analysis reveals that distinct neuropsychiatric disorders associate with distinct sets of neuron-specific genes but converge onto shared loci within oligodendrocytes and oligodendrocyte precursors. This atlas guides our aetiological understanding by associating SN cell type expression profiles with specific disease risk.
Surface oxygenation of multicomponent nanoparticles toward active and stable oxidation catalysts
Authors: Shan Shiyao , Li Jing , Maswadeh Yazan , O’Brien Casey , Kareem Haval , Tran Dat T. , Lee Ivan C. , Wu Zhi-Peng , Wang Shan , Yan Shan , Cronk Hannah , Mott Derrick , Yang Lefu , Luo Jin , Petkov Valeri , Zhong Chuan-Jian 
Published: August 2020

AbstractThe need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral interface. Here we report a new approach to oxidation catalysts for total oxidation of hydrocarbons (e.g., propane) by surface oxygenation of platinum (Pt)-alloyed multicomponent nanoparticles (e.g., platinum-nickel cobalt (Pt–NiCo)). The in-situ/operando time-resolved studies, including high-energy synchrotron X-ray diffraction and diffuse reflectance infrared Fourier transform spectroscopy, demonstrate the formation of oxygenated Pt–NiOCoO surface layer and disordered ternary alloy core. The results reveal largely-irregular oscillatory kinetics associated with the dynamic lattice expansion/shrinking, ordering/disordering, and formation of surface-oxygenated sites and intermediates. The catalytic synergy is responsible for reduction of the oxidation temperature by ~100 °C and the high stability under 800 °C hydrothermal aging in comparison with Pt, and may represent a paradigm shift in the design of self-supported catalysts.
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
Authors: Wu Qin , ba-alawi Wail , Deblois Genevieve , Cruickshank Jennifer , Duan Shili , Lima-Fernandes Evelyne , Haight Jillian , Tonekaboni Seyed Ali Madani , Fortier Anne-Marie , Kuasne Hellen , McKee Trevor D. , Mahmoud Hassan , Kushida Michelle , Cameron Sarina , Dogan-Artun Nergiz , Chen WenJun , Nie Yan , Zhang Lan Xin , Vellanki Ravi N. , Zhou Stanley , Prinos Panagiotis , Wouters Bradly G. , Dirks Peter B. , Done Susan J. , Park Morag , Cescon David W. , Haibe-Kains Benjamin , Lupien Mathieu , Arrowsmith Cheryl H. 
Published: August 2020

AbstractTriple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter 1 (GLUT1, encoded by SLC2A1) and associated metabolic dependencies in TNBC, we investigated the vulnerability of TNBC cell lines and patient-derived samples to GLUT1 inhibition. We report that genetic or pharmacological inhibition of GLUT1 with BAY-876 impairs the growth of a subset of TNBC cells displaying high glycolytic and lower oxidative phosphorylation (OXPHOS) rates. Pathway enrichment analysis of gene expression data suggests that the functionality of the E2F pathway may reflect to some extent OXPHOS activity. Furthermore, the protein levels of retinoblastoma tumor suppressor (RB1) strongly correlate with the degree of sensitivity to GLUT1 inhibition in TNBC, where RB1-negative cells are insensitive to GLUT1 inhibition. Collectively, our results highlight a strong and targetable RB1-GLUT1 metabolic axis in TNBC and warrant clinical evaluation of GLUT1 inhibition in TNBC patients stratified according to RB1 protein expression levels.