bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paraneoplastic pyoderma gangrenosum associated with adenocarcinoma of the rectosigmoid junction: a case report
Authors: Alassani Fousséni , Kassang Panawe , Amouzou Efoe-Ga , Tchangai Boyodi , Sakiye Kossi Abossisso , Darré Tchin , Saka Bayaki , Attipou Komla 
Published: December 2019

Abstract
Introduction
Pyoderma gangrenosum is a rare, idiopathic, inflammatory, neutrophilic dermatitis characterized by sterile skin ulceration. It can be associated with an underlying pathology, especially inflammatory bowel disease and hematological malignancies. Its association with a malignant pathology in the context of a paraneoplastic syndrome is more commonly described in hematological malignancies, with solid tumors being rare.

Case report
We report a case of a 39-year-old West African man with pyoderma gangrenosum that developed 6 months before the clinical expression of rectosigmoid junction cancer. The removal of the cancer resulted in the patient’s recovery.

Conclusion
Recurrent pyoderma gangrenosum lesions may be the expression of colonic adenocarcinoma in paraneoplastic syndrome and require colonoscopy, especially in at-risk patients.
Use of health outcome and health service utilization indicators as an outcome of access to medicines in Brazil: perspectives from a literature review
Authors: Arueira Chaves Luisa , de Souza Serio dos Santos Danielle Maria , Rodrigues Campos Monica , Luiza Vera Lucia 
Published: December 2019

Abstract
Background
To guarantee the right to health, the health system must also ensure access to medicines. Several financial arrangements to provide these technologies are implemented and range from the direct (either total or partial) to indirect payment by the patient, being necessary to evaluate its effect on access to medicines. However, to ensure access to medicines is not just about ensuring its availability, as this only materializes in its use. Thus, evaluation studies of interventions in access to medicines have been using indicators related to the health results and use of health services as its outcomes. Furthermore, as this relationship is not direct, it is important to critically assess the adequacy of these tools to measure this phenomenon and, additionally, the ability to use it in the Brazilian scenario. Therefore, this study sought to identify, describe, and analyze the use of these indicators as medicine access outcomes, through a review of the scientific literature.

Methods
An extensive literature review was done using a bibliographic database for a systematic review. The references were selected based on inclusion and exclusion criteria, and the indicators from the papers retained were analyzed using the parameters of validity, measurability, reliability, and relevance.

Results
We have analyzed over 12,000 references of which 30 references were included, describing the use of 49 health outcomes and health service use indicators. The majority reported the use of health service utilization measures. In our evaluation, the best indicators for assessing the effects of co-payment intervention on access are the ones aimed at specific populations or symptomatic health conditions in which the response to the therapeutic treatment is known and occurs in a short period of time. It was evident the lack of information on the indicators analyzed as well as the limitation of the Brazilian secondary databases for its calculation.

Conclusions
This research showed the variety and heterogeneity of the indicators used in scientific studies. The best indicators for access to medicines are sought to measure the use of health services for symptomatic health conditions that are quickly responsive to pharmacological treatment, while the indicators related to worker productivity loss was the most suitable for health outcomes.
Adjacent digit fingerprint white line count differences: a pointer to sexual dimorphism for forensic application
Authors: Taura Magaji Garba , Adamu Lawan Hassan , Asuku Abdullahi Yusuf , Umar Kabiru Bilkisu , Abubakar Musa 
Published: December 2019

AbstractBackgroundSex determination is one of the leading criterion in identification and verification of an individual. However, the potential roles of differences in adjacent fingerprint white line count (FWLC) in sex inference are not well elucidated in the literature especially among Hausa population. The study was conducted to determine sexual dimorphism and predict sex using adjacent digit FWLC difference (adj. DFWLCD) among Hausa population of Kano state, Nigeria.MethodsThe study population involved 300 participants. FWLC was determined from a plain fingerprint captured using live scanner. The formula for adj. DFWLCD of thumb and fifth digit is dR15 for right hand. The same applied for possible combination in cephalocaudal direction. Mann-Whitney andttests were used for comparison of variables between sexes. Binary logistic regression analyses were employed for determination of sex.ResultsWe observed a significantly larger adj. DFWLCD in males compared with females in most of the digit combination. A significant sexual dimorphism was observed in most of the adj. DFWLCD involving ring digit in both right (dR14, dR24, and dR34) and left (dL14, dL24, and dL34). The best discrimination was observed in adjacent FWLC difference of second and fourth digits in both right and left digits (dR24 and dL24). This was further supported by stepwise logistic regression analyses.ConclusionThe adj. DFWLCD exhibits sexual dimorphism. The best prediction potentials were found to be dR24 and dL24 for right and left hands respectively.
Clinical characteristics and in-hospital outcome of heart failure in women: a single center registry from Egyptian cardiac care unit
Authors: Badran Hala Mahfouz , Elgharably Marwa Ahmed , Faheem Naglaa 
Published: December 2019

Abstract
Background
This study represents figures from a cardiac care unit (CCU) of a university hospital; it describes an example of a tertiary academic center in Egypt and provides an epidemiological view of the female HF patients, their risk profile, and short-term outcome during hospitalization.

Results
It is a local single-center cross-sectional observational registry of CCU patients 1 year from July 2015 to July 2016. Patient’s data were collected through a special software program. Women with evidence of HF were thoroughly studied.
Among the 1006 patients admitted to CCU in 1 year, 345 (34.2%) patients were females and 118 (34.2%) had evidence of HF, whereas 661 (65.7%) were males and 178 (26.9%) of them had HF. Women with HF showed 11.7% prevalence of the total population admitted to CCU. 72.7% were HFrEF and 27.3% were HFpEF. Compared to men, women with HF were older in age, more obese, less symptomatic than men, had higher incidence of associated co-morbidities, less likely to be re-admitted for HF, and less likely to have ACS and PCI. Valvular heart diseases and cardiomyopathies were the commonest etiologies of their HF. Women had more frequent normal ECG, higher EF%, and smaller LA size. There is no difference in medications and CCU procedures. While females had shorter stay, there is no significant difference in hospital mortality compared to male patients.

Conclusions
Despite higher prevalence of HF in females admitted to CCU and different clinical characteristics and etiology of HF, female gender was associated with similar prognosis during hospital course compared to male gender.
РАСПРОСТРАНЕННОСТЬ ЭКСТРАГЕНИТАЛЬНЫХ ФАКТОРОВ РИСКА И ИХ ВЛИЯНИЕ НА НЕБЛАГОПРИЯТНЫЕ ИСХОДЫ БЕРЕМЕННОСТИ
Authors: Kurbanismailov Renat Badrudinovich , Narkevich Artem Nikolaevich , Vinogradov Konstantin Anatolyevich , Mironova Alena Andreevna 
Published: December 2019

Цель. Изучение распространенности экстрагенитальных факторов и их влияния на риск развития неблагоприятных исходов беременности в Красноярском крае.Материалы и методы. Для изучения факторов риска неблагоприятных исходов беременности использованы данные перинатального мониторинга Красноярского края, который функционирует на базе Красноярского краевого медицинского информационно-аналитического центра. В анализ включены данные о 122 250 случаях беременности в период с 2014 по 2017 гг. Все анализируемые случаи беременности распределены на 2 группы: I группа – случаи беременности с неблагоприятными исходами (8 290 случаев), II группа – случаи беременности с благоприятными исходами (113 960 случаев). В работе проанализированы следующие факторы: наличие сахарного диабета, артериальной гипертензии и гипотензивного синдрома, хронической специфической инфекции, заболеваний почек, варикозной болезни, тромбозов и тромбофлебитов, заболеваний щитовидной железы и надпочечников, пороков сердца без нарушения кровоснабжения, травм и переломов, нарушений мозгового кровообращения и миопии у матери.Результаты. Результаты проведенного исследования свидетельствуют о том, что большинство факторов оказывают влияния на риск развития неблагоприятных исходов беременности. В наибольшей степени на данный риск оказывают влияние наличие положительной реакции на волчаночный антикоагулянт, сахарного диабета, артериальной гипертензии II и III степени тяжести у матери.Заключение. Использование информации о распространенности и влиянии экстрагенитальных факторов на риск развития неблагоприятных исходов беременности позволит наиболее эффективно осуществлять маршрутизацию беременных по уровням оказания медицинской помощи для снижения числа неблагоприятный исходов беременности. Полученные результаты свидетельствуют о том, что на риск развития неблагоприятных исходов беременности оказывает влияние довольно широкий спектр факторов. При этом каждый фактор оказывает различное по степени влияние на данный риск.
АЛКОГОЛИЗМ КАК УГРОЗА СОЦИАЛЬНОЙ БЕЗОПАСНОСТИ НАСЕЛЕНИЯ ВОРОНЕЖСКОЙ ОБЛАСТИ
Authors: Yakovenko Nataliya Vladimirovna , Fedotov Vladimir Ivanovitch , Mikhno Vladimir Borisovitch , Safonova Irina Vyacheslavovna 
Published: December 2019

В условиях динамичности и неопределенности социальных процессов особую актуальность приобретают проблемы обеспечения безопасности, так как потребность в ней является базисным, мотивационным механизмом человеческой жизнедеятельности. Алкоголизм представляет собой комплекс медико-социальных патологий, которые крайне негативно влияют на нормальное функционирование российского общества. Эта проблема существует столько же, сколько существует само человечество. Однако именно в нынешних условиях нестабильности социально-экономических процессов и явлений она приобретает особую значимость. Алкоголизм представляет собой угрозу для социальной безопасности, так как наносит не только моральный, но социальный и экономический ущерб.Цель исследования: раскрыть проблему алкоголизации населения Воронежской области в контексте социальной безопасности.Материалы и методы. Основным методологическим подходом выступил системный, который дает возможность рассмотреть феномен алкоголизации населения в зависимости от внешних и внутренних факторов его возникновения, а также социальных изменений, обусловленных им.Результаты. Раскрыты основные тенденции, связанные с алкоголизмом в Воронежской области. Показаны динамика и тенденция заболеваемости алкоголизмом населения Воронежской области. Проведена классификация муниципальных образований региона по «территориям риска».Заключение. В современных условиях развития российского общества проблема социальной безопасности стоит очень остро. Алкоголизм выступает одной из угроз социального благополучия населения. Анализ ситуации в Воронежской области показывает необходимость разработки ряда мероприятий региональными органами власти с целью профилактики алкоголизации населения с учетом негативных, деструктивных последствий и угроз для социальной безопасности региона.
A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease
Authors: Zhao Xuemei , Kang John , Svetnik Vladimir , Warden Donald , Wilcock Gordon , David Smith A , Savage Mary J , Laterza Omar F 
Published: December 2019

AbstractBackgroundAccurate diagnosis of Alzheimer disease (AD) involving less invasive molecular procedures and at reasonable cost is an unmet medical need. We identified a serum miRNA signature for AD that is less invasive than a measure in cerebrospinal fluid.MethodsFrom the Oxford Project to Investigate Memory and Aging (OPTIMA) study, 96 serum samples were profiled by a multiplex (&gt;500 analytes) microRNA (miRNA) reverse transcription quantitative PCR analysis, including 51 controls, 32 samples from patients with AD, and 13 samples from patients with mild cognitive impairment (MCI). Clinical diagnosis of a subset of AD and the controls was confirmed by postmortem (PM) histologic examination of brain tissue. In a machine learning approach, the AD and control samples were split 70:30 as the training and test cohorts. A multivariate random forest statistical analysis was applied to construct and test a miRNA signature for AD identification. In addition, the MCI participants were included in the test cohort to assess whether the signature can identify early AD patients.ResultsA 12-miRNA signature for AD identification was constructed in the training cohort, demonstrating 76.0% accuracy in the independent test cohort with 90.0% sensitivity and 66.7% specificity. The signature, however, was not able to identify MCI participants. With a subset of AD and control participants with PM-confirmed diagnosis status, a separate 12-miRNA signature was constructed. Although sample size was limited, the PM-confirmed signature demonstrated improved accuracy of 85.7%, largely owing to improved specificity of 80.0% with comparable sensitivity of 88.9%.ConclusionAlthough additional and more diverse cohorts are needed for further clinical validation of the robustness, the miRNA signature appears to be a promising blood test to diagnose AD.
Quality Control of Preanalytical Handling of Blood Samples for Future Research: A National Survey
Authors: Gils Charlotte , Nybo Mads 
Published: December 2019

AbstractBackgroundAssessment and control of preanalytical handling of blood samples for future research are essential to preserve integrity and assure quality of the specimens. However, investigation is limited on how quality control of preanalytical handling of blood samples is performed by biobanks.MethodsA questionnaire was sent to all Danish departments of clinical biochemistry, all Danish departments of clinical immunology, the Danish Health Surveillance Institution and the Danish Cancer Society. The questionnaire consisted of questions regarding preanalytical handling of samples for future research. The survey was carried out from October 2018 until the end of January 2019.ResultsA total of 22 departments (78%) replied, of which 17 (77%) performed preanalytical quality control of the blood samples. This quality control consisted of patient preparation, temperature surveillance of freezers, maintenance of centrifuges, and visual inspection for hemolysis, lipemia, and sample volume. Automated sample check for hemolysis, icterus, and lipemia interferences was performed by 41% of respondents, not performed by 50% of respondents, and 9% did not answer. The majority (55%) of the participants stated that they had no local standard operating procedure for preanalytical handling of samples for research projects.ConclusionsThe preanalytical phase for blood samples obtained and preserved for future research in Denmark is highly heterogeneous, although many aspects (e.g., hemolysis, which also affects DNA analyses, metabolomics, and proteomics) seems highly relevant to document. Our findings emphasize the need to optimize and standardize best practices for the preanalytical phase for blood samples intended for use in future research projects.
Barragem do rio todos os santos no vale do mucuri/mg: análise de rompimento para Teófilo Otoni
Authors: Costa Alexandre Sylvio Vieira da , Silva Altamiro Junior Mendes , Colares Rodrigo Silva 
Published: December 2019

Grandes obras da engenharia são projetadas para solucionar ou minimizar problemas. Neste trabalho é apresentado um estudo sobre a barragem que visa abastecer e satisfazer as necessidades da região, mas que podem gerar alguns transtornos caso o barramento se rompa. Desta forma a pesquisa avaliou as ondas de inundação provenientes do rompimento hipotético da barragem de Teófilo Otoni-MG. Para a realização deste estudo foi utilizado o método das características descrito por Mascarenhas. A vazão máxima de ruptura calculada resultou no valor de 5739,34 m³/s, utilizando o hidrograma triangular simplificado de ruptura. O tempo estimado de esvaziamento do reservatório é de aproximadamente 4.460,44 segundos (1,24 horas). Com base nos dados encontrados, percebemos que a sede municipal de Teófilo Otoni, situada a 15 km da barragem, seria atingida por um fenômeno de galgamento, cuja altura seria de aproximadamente três metros. Observa-se, neste desfecho, que os resultados obtidos no desenvolvimento dessa proposta de estudo, podem ampliar as possibilidades de ações relativas à prevenção de catástrofes, no que tange à construção, manutenção e rompimento involuntário de uma barragem de contenção, e incentivar estratégias emergenciais de apoio, em caso de situações de risco iminente.
Genetic risk factors for behavioral adverse reactions in epileptic patients taking levetiracetam
Authors: Usoltseva A. A. , Dmitrenko D. V. , Zobova S. N. , Bochanova E. N. , Shnayder N. A. 
Published: December 2019

Levetiracetam (LEV) is an effective antiepileptic drug. Nevertheless, when the drug is used, its behavioral adverse drug reactions (ADRs), such as aggressivity, irritability, hyperexcitability, and anxiety, occur in almost 30% of cases. Recent studies show that personality traits can predispose to LEV-induced ARs.Objective: to establish genetic risk factors for behavioral ADRs in epileptic patients taking LEV. Patients and methods. Single nucleotide variants (SNVs) were chosen according to their importance for the development of impulsivity and aggressivity. At Stage 1, the dose-dependent effect of LEV, which was responsible for behavioral ADRs, was studied in 179 epileptic patients taking this drug, who were divided into four groups according to age and the presence of ADRs. Molecular genetic testing of SNVs DRD2 rs1800497 (DRD2/ANKK1 Taq1A), COMT rs4680, and DBH rs1611115 was done at Stage 2. Results and discussion. The ADR and non-ADR groups showed no statistically significant differences in the daily dose of LEV in both children (696.1 and 500.0 mg/day, respectively; p=0.087) and adults (750.9 and 750.9 mg/day, respectively; p=0.13). The similar data were obtained for blood LEV concentrations in children (31.6 and 27.3 μg/ml, p=0.12) and in adults (23.1 and 17.6 μg/ml, respectively; p=0.12). There was a statistically significant association between the carriage of the heterozygous CT genotype of SNV rs1611115 and the rate of both behavioral (OR, 3.38; 95% CI, 1.25–9.14; p=0.042) and CNS ADRs in general (OR, 3.29; 95% CI, 1.29–8.44; p=0.036). Higher impulsivity values were recorded in the carriers of the CT + TT genotypes of SNV rs1800497 (p<0.05) and rs1611115 (p<0.01) compared with those of the CC genotype. No statistically significant intergroup differences were obtained for SNV COMP rs4680. Conclusion. The dose-dependent effect of behavioral ADRs is absent in both pediatric and adult patients taking LEV. Increased impulsiveness in epileptic patients taking LEV is associated with the carriage of SNV rs1800497 and rs1611115. The LEV-induced behavioral ADRs are related to SNV DBH rs1611115 that can be considered as one of the potential genetic predictors for behavioral ADRs and impulsivity.
ETHNOCULTURAL DIFFERENCES IN IMPLICIT REPRESENTATIONS ABOUT A VIABLE PERSON
Authors: Yashchenko Elena Fedorovna , Sarkisyan Liliya Vaganovna , Melaten Rimma Raisovna 
Published: December 2019

Aim. The idea of studying implicit representations about a resilient person in the crosscultural context is of great interest in establishing the strategies of resilience. Materials and methods. At first stage, the associative experiment was conducted based on responses to a “resilient person” stimulus. At the next stage, the method of subjective scaling was used. The results obtained were processed with factor analysis using the Statistica 15.0 software. Results. Various factor structures of mental representations of a resilient person were revealed. Conclusion. During the study, it was revealed that ordinary representations about a resilient person in respondents from Russia, Kazakhstan and the USA possess similarities and differences. All respondents associate high resilience with the meaning of life, optimism and love of life. Respondents emphasize a high significance of determination, adaptability, self-development and personal growth. The factor structure of implicit representations in Russian students matched the results of an earlier factorization in adult Russians. Pronounced cross-cultural differences were revealed in associationsregarding family. These associations are significant for students from Kazakhstan and the USA but do not fall into the area of significance for Russians. Young people from the USA perceive the family as something that contributes to one’s resilience. Kazakh students associate resilience with the ability to create and maintain a family, to meet the hope of parents. Kazakh students consider the meaning of life, optimism, humanity, faith in God (Allah), service to him, humility (“not to be proud”) as the main things for maintaining resilience. For Russians and Americans, their pride and self-esteem are considered as more important in maintaining resilience. For Americans, resilience is determined by strength and endurance. Russian students are convinced that a resilient person consists of determination, independence, intelligence, adaptive abilities and success.
Calculating macroalgal height and biomass using bathymetric LiDAR and a comparison with surface area derived from satellite data in Nova Scotia, Canada
Authors: Webster Tim , MacDonald Candace , McGuigan Kevin , Crowell Nathan , Lauzon-Guay Jean-Sebastien , Collins Kate 
Published: December 2019

Abstract
The ability to map and monitor the macroalgal coastal resource is important to both the industry and the regulator. This study evaluates topo-bathymetric lidar (light detection and ranging) as a tool for estimating the surface area, height and biomass of Ascophyllum nodosum, an anchored and vertically suspended (floating) macroalga, and compares the surface area derived from lidar and WorldView-2 satellite imagery. Pixel-based Maximum Likelihood classification of low tide satellite data produced 2-dimensional maps of intertidal macroalgae with overall accuracy greater than 80%. Low tide and high tide topo-bathymetric lidar surveys were completed in southwestern Nova Scotia, Canada. Comparison of lidar-derived seabed elevations with ground-truth data collected using a survey grade global navigation satellite system (GNSS) indicated the low tide survey data have a positive bias of 15 cm, likely resulting from the seaweed being draped over the surface. The high tide survey data did not exhibit this bias, although the suspended canopy floating on the water surface reduced the seabed lidar point density. Validation of lidar-derived seaweed heights indicated a mean difference of 30 cm with a root mean square error of 62 cm. The modelled surface area of seaweed was 28% greater in the lidar model than the satellite model. The average lidar-derived biomass estimate was within one standard deviation of the mean biomass measured in the field. The lidar method tends to overestimate the biomass compared to field measurements that were spatially biased to the mid-intertidal level. This study demonstrates an innovative and cost-effective approach that uses a single high tide bathymetric lidar survey to map the height and biomass of dense macroalgae.