bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Retirement, Social Class, and Family Relationships in Cloutier’s Bonne retraite, Jocelyne (2018)
Authors: Mina-Riera Núria , Voyer Véronique 
Published: March 2020

AbstractBackground and ObjectivesAging women are continuously underrepresented in performing arts. An exception to this trend in Québec is Fabien Cloutier’s latest play Bonne retraite, Jocelyne (2018), whose protagonist is a middle-aged woman who has decided to take early retirement. This article aims at examining the interplay between the protagonist’s voluntary early retirement, gender, social class, and family relationships.Research Design and MethodsThis article mobilizes the theoretical framework of aging studies, which is underdeveloped in the French academic sphere. This qualitative case study connects gender issues and performative strategies in order to study a complex phenomenon within its context.ResultsWe showed that Cloutier provides new representations of middle-aged women in his play, a corrective to the under-representation of such an age group of actors and actresses in Québec. Our results cast a new light on the combination of class privilege, gender, and ageism, as a most fruitful research orientation to be further developed in the future in order to pursue an in-depth analysis of early retirement.Discussion and ImplicationsThe play reveals that belonging to the upper-middle class is essential in order to be able, economically speaking, to retire early. Cloutier empowers Jocelyne both as an aging individual and as a woman by means of granting her the right to make her own decisions in life.
Introgression of Eastern Chinese and Southern Chinese haplotypes contributes to the improvement of fertility and immunity in European modern pigs
Authors: Chen Hao , Huang Min , Yang Bin , Wu Zhongping , Deng Zheng , Hou Yong , Ren Jun , Huang Lusheng 
Published: March 2020

Abstract

Background
Pigs were domesticated independently from European and Asian wild boars nearly 10,000 years ago. Chinese indigenous pigs have been historically introduced to improve Europe local pigs. However, the geographic origin and biological functions of introgressed Chinese genes in modern European pig breeds remain largely unknown.

Results
Here we explored whole-genome sequencing data from 266 Eurasian wild boars and domestic pigs to produce a fine-scale map of introgression between French Large White (FLW) and Chinese pigs. We show that FLW pigs had historical admixture with both Southern Chinese (SCN) and Eastern Chinese (ECN) pigs ~200–300 years ago. Moreover, a set of SCN haplotypes was shown to be beneficial for improving disease resistance and ECN haplotypes are favorable for improved reproductive performance in FLW pigs. In addition, we confirm human-mediated introgression events at the AHR locus, at which the haplotype of most likely ECN origin contributes to increased fertility of FLW pigs.

Conclusions
This study advances our understanding of the breeding history of global domestic pigs and highlights the importance of artificial introgression in the formation of phenotypic characteristics in domestic animals.
Quantification and Characterization of Phenolic Compounds from Northern Indian Propolis Extracts and Dietary Supplements
Authors: Avula Bharathi , Sagi Satyanarayanaraju , Masoodi Mubashir H , Bae Ji-Yeong , Wali Adil F , Khan Ikhlas A 
Published: March 2020

Abstract

Background
Propolis is a resinous substance produced by bees. Propolis extracts have been used for anti-inflammatory and antimicrobial activities. The use of propolis dietary supplements has been increasing in the United States and the rest of the world.

Objective
A simple, economic, and valid analytical method is needed for quality assessment of dietary supplements and extracts claiming to contain propolis.

Methods
A ultra-high performance liquid chromatography (UHPLC) quadropole time-of-flight-MS method was used to characterize the chemical composition of northern Indian propolis. Fourteen major phenolic compounds were quantified using a UHPLC-DAD method. An HPTLC method was used to develop chemical fingerprinting profiles for propolis extracts and dietary supplements. The seven propolis extracts and 14 dietary supplements purchased in the U.S. were analyzed using the UHPLC-DAD-QToF method.

Results
Fifty-seven compounds belonging to phenolic, coumarin, fatty acid, and terpene classes were identified in propolis extracts. Based on quantification results, the content of 14 phenolic compounds in propolis extracts varied from 19–32% in dietary supplements, a significant variation to the recommended daily intake (0.2–94 mg/day).

Conclusions/Highlights
The developed analytical methods can be used for quality assessment of propolis extracts and dietary supplements.
Multiple Respiratory Syncytial Virus Introductions Into a Neonatal Intensive Care Unit
Authors: Rose Erica Billig , Washington Erica J , Wang Lijuan , Benowitz Isaac , Thornburg Natalie J , Gerber Susan I , Peret Teresa C T , Langley Gayle E 
Published: March 2020

Abstract

Background
Outbreaks of respiratory syncytial virus (RSV) in neonatal intensive care units (NICUs) are of concern because of the risk of severe disease in young infants. We describe an outbreak of RSV in a NICU and use whole genome sequencing (WGS) to better understand the relatedness of viruses among patients.

Methods
An investigation was conducted to identify patients and describe their clinical course. Infection control measures were implemented to prevent further spread. Respiratory specimens from outbreak-related patients and the community were tested using WGS. Phylogenetic trees were constructed to understand relatedness of the viruses.

Results
Seven patients developed respiratory symptoms within an 11-day span in December 2017 and were diagnosed with RSV; 6 patients (86%) were preterm and 1 had chronic lung disease. Three patients required additional respiratory support after symptom onset, and none died. Six of 7 patients were part of the same cluster based on &gt; 99.99% nucleotide agreement with each other and 3 unique single-nucleotide polymorphisms were identified in viruses sequenced from those patients. The seventh patient was admitted from the community with respiratory symptoms and had a genetically distinct virus that was not related to the other 6. Implementation of enhanced infection control measures likely limited the spread.

Conclusions
Using WGS, we found 2 distinct introductions of RSV into a NICU, highlighting the risk of healthcare-associated infections during RSV season. Early recognition and infection control measures likely limited spread, emphasizing the importance of considering RSV in the differential diagnosis of respiratory infections in healthcare settings.
Differentiating disc and black hole-driven jets with EHT images of variability in M87
Authors: Jeter Britton , Broderick Avery E , Gold Roman 
Published: March 2020

ABSTRACTMillimetre-wavelength very long baseline interferometric (mm-VLBI) observations of M87 by the Event Horizon Telescope (EHT) should provide a unique opportunity to observe and characterize the origins of jet variability already seen at longer wavelengths. Synchrotron spot models have been used to model variability near black holes; this work extends these by allowing spots to shear and deform in the jet velocity field. Depending on the position of the spot, shearing forces can significantly alter the structure of the spot, producing distinct signals in reconstructed images and light curves. The maximum intensity of the shearing spot can vary by as much as a factor of 5 depending on the spot azimuthal launch position, but the intensity decay time depends most significantly on the spot radial launch position. Spots launched by a black hole-driven jet exhibit distinct arc structures in reconstructed images, and exhibit brighter and shorter lived enhancements of the light curve. Spots launched by a wind-driven jet have exhibit much simpler structures in the image, and longer lived light-curve enhancements than spots launched by a black hole-driven jet.
Probing the size and charge of polycyclic aromatic hydrocarbons
Authors: Maragkoudakis A , Peeters E , Ricca A 
Published: March 2020

ABSTRACT
We present a new method to accurately describe the ionization fraction and the size distribution of polycyclic aromatic hydrocarbons (PAHs) within astrophysical sources. To this purpose, we have computed the mid-infrared emission spectra of 308 PAH molecules of varying sizes, symmetries, and compactness, generated in a range of radiation fields. We show that the intensity ratio of the solo CH out-of-plane bending mode in PAH cations and anions (referred to as the ‘11.0’ μm band, falling in the 11.0–11.3 μm region for cations and anions) to their 3.3 μm emission scales with PAH size, similarly to the scaling of the 11.2/3.3 ratio with the number of carbon atoms (NC) for neutral molecules. Among the different PAH emission bands, it is the 3.3 μm band intensity that has the strongest correlation with NC, and drives the reported PAH intensity ratio correlations with NC for both neutral and ionized PAHs. The 6.2/7.7 intensity ratio, previously adopted to track PAH size, shows no evident scaling with NC in our large sample. We define a new diagnostic grid space to probe PAH charge and size, using the (11.2 + 11.0)/7.7 and (11.2 + 11.0)/3.3 PAH intensity ratios, respectively. We demonstrate the application of the (11.2 + 11.0)/7.7–(11.2 + 11.0)/3.3 diagnostic grid for galaxies M82 and NGC 253, for the planetary nebula NGC 7027, and the reflection nebulae NGC 2023 and NGC 7023. Finally, we provide quantitative relations for PAH size determination depending on the ionization fraction of the PAHs and the radiation field they are exposed to.
Neural physical engines for inferring the halo mass distribution function
Authors: Charnock Tom , Lavaux Guilhem , Wandelt Benjamin D , Sarma Boruah Supranta , Jasche Jens , Hudson Michael J 
Published: March 2020

ABSTRACT
An ambitious goal in cosmology is to forward model the observed distribution of galaxies in the nearby Universe today from the initial conditions of large-scale structures. For practical reasons, the spatial resolution at which this can be done is necessarily limited. Consequently, one needs a mapping between the density of dark matter averaged over ∼Mpc scales and the distribution of dark matter haloes (used as a proxy for galaxies) in the same region. Here, we demonstrate a method for determining the halo mass distribution function by learning the tracer bias between density fields and halo catalogues using a neural bias model. The method is based on the Bayesian analysis of simple, physically motivated, neural network-like architectures, which we denote as neural physical engines, and neural density estimation. As a result, we are able to sample the initial phases of the dark matter density field while inferring the parameters describing the halo mass distribution function, providing a fully Bayesian interpretation of both the initial dark matter density distribution and the neural bias model. We successfully run an upgraded borg (Bayesian Origin Reconstruction from Galaxies) inference using our new likelihood and neural bias model with halo catalogues derived from full N-body simulations. In preliminary results, we notice there could potentially be orders of magnitude improvement in modelling compared to classical biasing techniques.
Binary–binary scattering in the secular limit
Authors: Hamers Adrian S , Samsing Johan 
Published: March 2020

ABSTRACT
Binary–binary interactions are important in a number of astrophysical contexts including dense stellar systems such as globular clusters. Although less frequent than binary–single encounters, binary–binary interactions lead to a much richer range of possibilities such as the formation of stable triple systems. Here, we focus on the regime of distant binary–binary encounters, i.e. two binaries approaching each other on an unbound orbit with a periapsis distance Q much larger than the internal binary separations. This ‘secular’ regime gives rise to changes in the orbital eccentricities and orientations, which we study using analytic considerations and numerical integrations. We show that ‘direct’ interactions between the three orbits only occur starting at a high expansion order of the Hamiltonian (hexadecupole order), and that the backreaction of the outer orbit on the inner two orbits at lower expansion orders is weak. Therefore, to good approximation, one can obtain the changes of each orbit by using previously known analytic results for binary–single interactions, and replacing the mass of the third body with the total mass of the companion binary. Nevertheless, we find some dependence of the ‘binarity’ of the companion binary, and derive explicit analytic expressions for the secular changes that are consistent with numerical integrations. In particular, the eccentricity and inclination changes of orbit 1 due to orbit 2 scale as ϵSA, 1(a2/Q)2[m3m4/(m3 + m4)2], where ϵSA, 1 is the approximate quadrupole-order change, and a2 and (m3, m4) are the companion binary orbital semimajor axis and component masses, respectively. Our results are implemented in several python scripts that are freely available.
Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level
Authors: He Dongxu , Mao Aiqin , Zheng Chang-Bo , Kan Hao , Zhang Ka , Zhang Zhiming , Feng Lei , Ma Xin 
Published: March 2020

Abstract
The aorta, with ascending, arch, thoracic and abdominal segments, responds to the heartbeat, senses metabolites and distributes blood to all parts of the body. However, the heterogeneity across aortic segments and how metabolic pathologies change it are not known. Here, a total of 216 612 individual cells from the ascending aorta, aortic arch, and thoracic and abdominal segments of mouse aortas under normal conditions or with high blood glucose levels, high dietary salt, or high fat intake were profiled using single-cell RNA sequencing. We generated a compendium of 10 distinct cell types, mainly endothelial (EC), smooth muscle (SMC), stromal and immune cells. The distributions of the different cells and their intercommunication were influenced by the hemodynamic microenvironment across anatomical segments, and the spatial heterogeneity of ECs and SMCs may contribute to differential vascular dilation and constriction that were measured by wire myography. Importantly, the composition of aortic cells, their gene expression profiles and their regulatory intercellular networks broadly changed in response to high fat/salt/glucose conditions. Notably, the abdominal aorta showed the most dramatic changes in cellular composition, particularly involving ECs, fibroblasts and myeloid cells with cardiovascular risk factor-related regulons and gene expression networks. Our study elucidates the nature and range of aortic cell diversity, with implications for the treatment of metabolic pathologies.
Cytomegalovirus in Adult Allogeneic Blood and Marrow Transplant Patients Before or Around the Period of Neutrophil Recovery: A Single-Center, Retrospective, Descriptive Study
Authors: Martin Isabella , Valsamakis Alexandra , Gladstone Douglas , Jones Richard , Ambinder Richard , Avery Robin K 
Published: March 2020

Abstract

Background
Few reports exist on pre-engraftment cytomegalovirus (CMV) DNAemia in allogeneic blood or marrow transplant (allo BMT) recipients. We describe this clinical entity, its management, and the potential effect of 3 different quantitative CMV deoxyribonucleic acid (DNA) tests used during the 6-year study period.

Methods
We performed a retrospective, single-center study of allo BMT recipients from 2010 to 2015 who developed CMV DNAemia before neutrophil recovery (absolute neutrophil count [ANC] &lt;1000 cells/mm3, “pre-engraftment CMV”) or who became neutropenic concomitant with detectable CMV DNA (“peri-engraftment CMV”). Clinical data were collected from the electronic medical record.

Results
Among 1151 adult allo BMT patients, 73 developed CMV DNAemia before engraftment or while neutropenic after initial engraftment. Most patients were eventually treated (valganciclovir or ganciclovir, N = 68; foscarnet, N = 1); 4 were not treated. First CMV detection occurred at median day +12 (range, 0–48), but treatment was not started until median day +33 (range, 4–105) at median ANC of 760 cells/mm3. Six patients had peak viral loads &gt;5000 IU/mL; none had tissue-invasive disease. One developed ganciclovir resistance. No significant differences were observed upon stratification by quantitative CMV DNA test.

Conclusions
Cytomegalovirus DNA was detected in 6.3% of pre- and peri-engraftment allo-HSCT patients. Ganciclovir derivatives were commonly used for treatment despite risk of neutropenia. Treatment was typically deferred until CMV DNA and ANC rose. With rare exceptions, this treatment strategy did not appear to have adverse clinical consequences with respect to acute CMV. Different CMV DNA quantification tests used performed similarly from a clinical perspective despite different analytical performance characteristics.
Robotic-Assisted Stereotaxy for Deep Brain Stimulation Lead Implantation in Awake Patients
Authors: Faraji Amir H , Kokkinos Vasileios , Sweat James C , Crammond Donald J , Richardson R Mark 
Published: March 2020

Abstract

BACKGROUND
Robotic-assisted stereotaxy has been increasingly adopted for lead implantation in stereoelectroencephalography based on its efficiency, accuracy, and precision. Despite initially being developed for use in deep brain stimulation (DBS) surgery, adoption for this indication has not been widespread.

OBJECTIVE
To describe a recent robotic-assisted stereotaxy experience and workflow for DBS lead implantation in awake patients with and without microelectrode recording (MER), including considerations for intraoperative research using electrocorticography (ECoG).

METHODS
A retrospective review of 20 consecutive patients who underwent simultaneous bilateral DBS lead implantation using robotic-assisted stereotaxy was performed. Radial error was determined by comparing the preoperative target with the DBS lead position in the targeting plane on postoperative computed tomography. Information regarding any postoperative complications was obtained by chart review.

RESULTS
A novel method for robot coregistration was developed. We describe a standard workflow that allows for MER and/or ECoG research, and a streamlined workflow for cases in which MER is not required. The overall radial error for lead placement across all 20 patients was 1.14 ± 0.11 mm. A significant difference (P = .006) existed between the radial error of the first 10 patients (1.46 ± 0.19 mm) as compared with the second 10 patients (0.86 ± 0.09 mm). No complications were encountered.

CONCLUSION
Robotic-assisted stereotaxy has the potential to increase precision and reduce human error, compared to traditional frame-based DBS surgery, without negatively impacting patient safety or the ability to perform awake neurophysiology research.
Arabidopsis Sucrose Transporter AtSuc1 introns act as strong enhancers of expression
Authors: Lasin Praphapan , Weise Andreas , Reinders Anke , Ward John M 
Published: March 2020

Abstract
The expression of AtSUC1 is controlled by the promoter and intragenic sequences. AtSUC1 is expressed in roots, pollen and trichomes. However, AtSUC1 promoter-GUS transgenics only show expression in trichomes and pollen. Here, we show that the root expression of AtSUC1 is controlled by an interaction between the AtSUC1 promoter and two short introns. The deletion of either intron from whole-gene-GUS constructs results in no root expression, showing that both introns are required. The two introns in tandem, fused to GUS, produce high constitutive expression throughout the vegetative parts of the plant. When combined with the promoter, the expression driven by the introns is reduced and localized to the roots. In Arabidopsis seedlings, exogenously applied sucrose induces the expression of AtSUC1 in roots and causes anthocyanin accumulation. atsuc1 loss-of-function mutants are defective in sucrose-induced anthocyanin accumulation. We show that an AtSUC1 whole-gene-GUS construct expressing a nonfunctional AtSUC1 (D152N) mutant, that is transport inactive, is defective in sucrose-induced AtSUC1 expression when expressed in an atsuc1-null background. We also show that the transport-defective allele does not complement the loss of sucrose-induced anthocyanin accumulation in null atsuc1 mutants. The results indicate that sucrose uptake via AtSUC1 is required for sucrose-induced AtSUC1 expression and sucrose-induced anthocyanin accumulation and that the site for sucrose detection is intracellular.
Some Universal Solutions for a Class of Incompressible Elastic Body that is Not Green Elastic: The Case of Large Elastic Deformations
Authors: Bustamante R 
Published: March 2020

Summary
Some universal solutions are studied for a new class of elastic bodies, wherein the Hencky strain tensor is assumed to be a function of the Kirchhoff stress tensor, considering in particular the case of assuming the bodies to be isotropic and incompressible. It is shown that the families of universal solutions found in the classical theory of nonlinear elasticity, are also universal solutions for this new type of constitutive equation.
What does cultural innovation stand for? Dimensions, processes, outcomes of a new innovation category
Authors: Pozzo Riccardo , Filippetti Andrea , Paolucci Mario , Virgili Vania 
Published: March 2020

AbstractThis article introduces the notion of cultural innovation, which requires adapting our approach to co-creation. The argument opens with a first conceptualization of cultural innovation as an additional and autonomous category of the complex processes of co-creation. The dimensions of cultural innovation are contrasted against other forms of innovation. In a second step, the article makes an unprecedented attempt in describing processes and outcomes of cultural innovation, while showing their operationalization in some empirical case studies. In the conclusion, the article considers policy implications resulting from the novel definition of cultural innovation as the outcome of complex processes that involve the reflection of knowledge flows across the social environment within communities of practices while fostering the inclusion of diversity in society. First and foremost, cultural innovation takes a critical stance against inequalities in the distribution of knowledge and builds innovation for improving the welfare of individuals and communities.