bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foreign language learning: controversies of virtuality and globality
Authors: Zeguniene Vaida , Kupriene Laima 
Published: February 2020

<p>Proficiency in any foreign language or languages is very inspirational. Infinite desire, tough self-discipline and personal attempts are vitally important factors in foreign language learning. Unfortunately, this idea ends when learning difficulties appear. They can stop learners and isolate them from future progress. According to the scholars and practitioners, there is a solution – to make learning more modernized by incorporating virtual and global technologies. This study will investigate the issue of effectiveness of foreign language learning in the context of globality and virtuality discourses. Nowadays young people represent the global digital generation that demonstrates excessive and habitual use of technologies. Considering that issue, the article discusses the controversial role of globality and virtuality in learning a foreign language.</p><p> </p>
La construcción del diálogo en La Celestina: las secuencias de reparación=The construction of dialogue in La Celestina: repair sequences
Authors: Iglesias Recuero Silvia 
Published: February 2020

En este trabajo mostramos cómo se adaptan y se utilizan en La Celestina determinadas secuencias típicamente conversacionales y las construcciones o formatos lingüísticos asociados a ellas. En concreto, nos centramos en las secuencias de reparación y estudiamos sus formas lingüísticas y sus funciones conversacionales y textuales para poner de manifiesto cómo contribuyen de manera decisiva a la verosimilitud del diálogo celestinesco. AbstractIn this paper we show how some typically conversational sequences and the linguistic formats related to them are adapted and exploited for the construction of dramatic dialogue. Especifically we focus on repair sequences in Celestina and we study their linguistic formats and conversational and textual functioning to reveal their crucial contribution to verosimility of Celestina ‘s dialogue.
BUSINESS MAJOR STUDENTS’ PERCEPTION TOWARDS BASIC ACCOUNTING COURSES IN HIGHER EDUCATION INSTITUTIONS OF OMAN
Authors: Rahman Khan Firdouse , Ali Salim Al Mamari Hasan 
Published: February 2020

Purpose: The objective of the study is to find out the areas in which the business students lack and to analyze the reasons for such lack of knowledge.
Design/methodology/approach: For carrying out the research study, 160 students from various Higher Education Institutions (HEIs) in Oman studying accounting subjects were selected and a test was conducted with five identified areas of accounting – accounting concepts, application knowledge, accounting formulae, accounting methods, and decision making. After completion of the test, the results were shown, and the correct answer keys were explained. Subsequently, a questionnaire mentioning all the five areas and the difficulties faced therein were requested to be filled in by the respondents.
Findings: The results of the empirical study reveal that the students assume that they are good at accounting but they lack knowledge of application, formulae usage, and decision making.
Practical Implications: It is confirmed that the concepts, methodologies, and techniques are not difficult but proper guidance and proper education methods through real-world examples might help towards creating interest among the students to improve their way of learning.
Social Implications: The study has identified the areas where the students lack and helps the teachers to improve their methods of teaching and the students to improve their way of learning.
Originality/value: No study has investigated before the accounting learning difficulties of business major students, and this study will help accounting educators to introduce and modify their teaching strategies.
St. Anselm of Canterbury (1033-1109 AD): His Contributions to the Intellectual Developments on Medieval Scholasticism
Authors: Thamrindinata Hendra 
Published: February 2020

<p class="abstracttextDILIGENTIA">Medieval scholasticism, considering its perennial influence for six centuries in the European universities, is an important intellectual power that deserves to be taken into account. In order to obtain a clearer picture of medieval scholasticism, it is necessary to have a precise understanding on the contributions of early medieval scholastic theologians who have laid the foundation for its subsequent developments. Therefore, this article will elaborate the thought of St. Anselm of Canterbury by analyzing his relevant works conceptually, discovering aspects of his thought which are foundational and significant for the subsequent intellectual developments of medieval scholasticism, exposing these aspects in detail, and tracing their influences on later theologians or periods. This elaboration finds four aspects of his thought and will expose it in detail: his view on faith seeking understanding, on teaching methodology, on the doctrine of satisfaction, and on the necessity of incarnation and satisfaction. The detailed exposition of these four aspects will substantiate the title conferred on him by Ulrich G. Leinsle as “the father of scholasticism.” </p>
Tempo de punir e disciplinar: Uma história da instrução na Paraíba (1822 a 1864)
Authors: Miranda Itacyara Viana 
Published: February 2020

O ato de revisitar, recriar e reinterpretar o passado da História da Educação paraibana se torna relevante na medida em que contribui com a produção historiográfica local. Paracompreender as dimensões que concorrem para definir a instrução na Província da Paraíba do Norte no século XIX, se faz necessárioum estudo mais aguçado acerca da dinâmica das relações que se desenvolvem na instrução. O objetivo é apreender as relações de poder entre os vários sujeitos da educação é apreender os métodos disciplinares e punitivos, procurando trazer à tona as “práticas” quase sempre silenciadas. O recorte vai de 1822 com a implantação da monarquia até 1864 quando acorre uma grande reforma na instrução pública e particular na Paraíba. O corpus documental utilizado é retirado do Arquivo Público do Estado da Paraíba - FUNESC e da Coleção de Leis e Regulamentos do INEP; são leis, regulamentos, petições, cartas e requerimentos. A documentação permite visualizar mesmo que parcialmente as práticas normativas e disciplinares empregadas pelo Governo Imperial e o Governo Provincial. Isso nos leva a concluir que a instrução era o elemento norteador da civilização. Ordem, norma e disciplina eram os ideais a serem perseguidos em prol da formação e a consolidação do Estado – Nacional.
New Materials and Technologies for Life-Lasting Cement Sheath: A Review of Recent Advances
Authors: Jafariesfad Narjes , Sangesland Sigbjørn , Gawel Kamila , Torsæter Malin 
Published: February 2020

SummaryThe key objective of well cementing has always been to provide zonal isolation in oil, gas, and carbon dioxide (CO2) storage wells to ensure safety and prevent environmental problems. The loss of zonal isolation and wellbore failures are mostly associated with inappropriate cementing and/or cement-sheath stability problems. Depending on the operations in a well, the cement sheath can experience a range of conditions that might induce its failure. To provide a long-term zonal isolation, the cement sheath should be designed to work throughout the entire lifetime of a well. Advances in materials and technologies, such as nanomaterials, polymeric materials, controlled processes, and electrokinetic processes, are currently implemented, and can further be implemented, by the cement industry to solve problems encountered in oil/gas well cementing. This paper provides a review of advances in applications of nanomaterials in oil/gas well cementing. These include expansive nanoadditives for shrinkage mitigation, nanorubber (NR)/flexible particles for modifying mechanical properties, and charged nanoparticles for hardened-cement treatment. In addition, new technologies, such as electrokinetic methods, self-sealing processes, and controlled-release processes for adjusting cement properties, are also reviewed. We discuss how these new materials and technologies can be the solution for providing a life-lasting cement sheath, through enhanced performance of the cement sheath with reasonable cost and minimized environmental effect, both of which have high importance in the oil/gas industry.
High Dose and Low Dose Oxytocin Regimens as Determinants of Successful Labor Induction: A multicenter comparative study
Authors: TESEMMA MELESE GEZAHEGN , Sori Demisew Amenu , Gemeda Desta Hiko 
Published: February 2020

Abstract

Background : Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of induction.
Methods : Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance.
Result : The mean “Induction to delivery time” was 5.9 hours and 6.3 hours for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of < 4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction.
Conclusions : In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction.We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction.
Reducing expression of dynamin-related protein 1 increases radiation sensitivity of glioblastoma cells
Authors: Shen Chiung-Chyi , Cheng Wen-Yu , Chow Kuan-Chih , Chiao Ming-Tsang , Yang Yi-Chi 
Published: February 2020

Abstract
Background: Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein imports, and drug sensitivity, suggesting an association with cancer progression. This study is to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). Methods : DRP1 expression was measured by immunohistochemistry and Western blotting. Correlations between DRP1 expression and clinicopathological parameters were by statistical analysis. Differences in survival were compared by a log-rank test. Results : DRP1 expression was detected in 87.2% (41/47) patients with GBM. Patients with higher DRP1 levels had worse survival ( p = 0.0398). In vitro , silencing of DRP1 reduced cell proliferation, invasive potential, and radiation resistance. The addition of shikonin inhibited DRP1 expression and increased drug uptake. Moreover, shikonin reduced the nuclear entry of DNA repair-associated enzymes and increased radiation sensitivity, suggesting that to reduce DRP1 expression could inhibit DNA repair and increase the radiation sensitivity of GBM cells. Conclusions : Our results indicate that DRP1 overexpression is a prospective radio-resistant phenotype in GBM. Therefore, DRP1 could be a potential target for improving the effectiveness of radiation therapy.
Identification and validation of a ten-gene set variation score as a diagnostic and prognostic stratification tools in hepatocellular carcinoma
Authors: Zhao Jinmin , Ye Jiazhou , Lin Yan , Bu Kunpeng , Mai Rongyun , Liu Ziyu , Gao Xing , Piao Xuemin , Liang Rong 
Published: February 2020

Abstract
We aimed to identify the progress of hepatocellular carcinoma (HCC)-specific gene set. Using the HCC data set from The Cancer Genome Atlas, we found that 10 genes were gradually up-graduated with the progress of HCC and associated with survival and classed as HCC-unfavorable gene set, while 29 genes were gradually down-graduated and associated with survival and classed as HCC-favorable gene set. Gene Set Variation Analysis (GSVA) was used to score individual samples against the two gene sets. ROC curve analysis showed both of HCC-unfavorable GSVA score and HCC-favorable GSVA score were reliable biomarkers for diagnosing HCC, tROC curve analysis and univariate/multivariate Cox proportional hazards analyses indicated that HCC-unfavorable GSVA score was an independently prognostic biomarkers. Moreover, the results were validated in an external independent data set. In addition, according to mutation and methylation analysis, we proposed that the aberrant expression of HCC-unfavorable gene may be driven by hypomethylation, not mutation.
Cross-institutional OSCE Quality Assurance in Europe using a mutual assessment strategy; are we equipped for it?
Authors: Kropmans Thomas JB , Søfteland Eirik , Wijnalda Anneke , Thoresen Marie , Hultin Magnus , Geoghegan Rosemary , Kubacki Angela Marie , Stassens Nick , McCarthy Suzanne , Hynes Stephen 
Published: February 2020

Abstract
BackgroundUntil 2008, Objective Structured Clinical Examinations (OSCE) were well researched, laborious and costly paper based method of exam delivery restricting international comparison. Cross-institutional comparison of OSCE Quality Assurance in Europe has never been done and due to wide spread electronic assessment analysis is now available.MethodsTwenty educational institutions across Europe using an electronic OSCE Management Information System where invited of which 8 confirmed to join a mutual comparison of Quality Assurance outcome. Two theories evaluate the quality of the observed test scores, the Classical psychometric theory (Cronbach’s alpha) and the Generalizability theory. Outcomes for both were compared for all universities including the Standard Error of Measurement (SEM) as well as cut-scores, Pass/Fail score and Global Rating Scores, Cronbach’s Alpha and related SEM (68% and 95% CI) and G-theory Coefficients with related absolute and relative SEM (68% and 95% CI). ResultsOutcomes differ between participating universities and observed marks contradict global rating of fail, borderline and excellent performance. G-theory coefficients and Standard Error of Measurement were lower and smaller compared to the classical approach using Cronbach’s Alpha as measure of reliability. The Classical psychometric based SEM varies from 2.8% to 11.2% respectively whereas the 95% CI equivalent varied from 9.2% up to 22% (on a 0 - 100% scale). The relative SEM from G-theory analysis varied from 3.1% to 7.0% for criterion-referenced marks, and the absolute SEM for norm-referenced marks varied from 3.8% to 7.8% respectively. The 95% CI around the relative and absolute SEMs values varied from 7.3% to 15.3%. More students failed the examination if the 95% CI is applied to the observed scores.ConclusionTo protect society and to improve educational decision making, the Standard Error of Measurement and associated confidence intervals needs to be embedded in EU assessment strategies to rule out ‘false positive Pass decisions’.
A novel signature based on six autophagy-related genes for prediction of overall survival in bladder cancer
Authors: Ding Hua , Wang Li-Wei , Zhang Jing-Qi , Liu Sha , Shi Jia-Zhong , Huang Ya-Qin , Zhou Xiao-Zhou , Yang Jin , Chen Zhi-Wen 
Published: February 2020

Abstract
Background Bladder cancer (BC) is the ninth most common carcinoma worldwide. Due to no improvement in treatment and survival over the past three decades, it is crucial to construct a robust model for risk assessment, prognosis prediction and refinement of therapy in clinical practice. The autophagy-related genes, with a key role in cancer biology, could have potential for prediction of survival or assistance in decision-making in treatment of bladder cancer. Methods Level 3 mRNA sequencing data from The Cancer Genome Atlas-Bladder Urothelial Carcinoma (TCGA-BLCA) was downloaded. We obtained 51 autophagy-related genes after survival analysis. Univariate Cox regression analysis, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis were conducted and a prognostic signature was established. We validated it in GSE13507 from Gene Expression Omnibus and explored the six genes’ methylation levels and their relationships with immune microenvironment and immune cells infiltration in online databases. The signature and independent clinical characteristics were integrated as a nomogram to facilitate treatment decision-making. Results A six-gene prognostic signature was constructed and stratified patients with BC into high-risk and low-risk groups. Meanwhile, it showed a good performance in overall survival prediction. Moreover, we found aberrant methylation in these genes and associations between them and tumor immune microenvironment and immune cells infiltration. Last, we demonstrated the independence of this signature from clinical parameters and a great value in treatment decision-making after its integrating with independent clinical factors. Conclusion The proposed six-gene signature showed promise for risk assessment and individualized survival prediction of BC and a nomogram based on it may facilitate the refinement of therapy.
The fecal microbiota evolves differently in piglets experimentally infected with Cystoisospora suis that are treated with toltrazuril
Authors: Shrestha Aruna , Metzler-Zebeli Barbara U. , Karembe Hamadi , Sperling Daniel , Joachim Anja 
Published: February 2020

Abstract
Background: The protozoan parasite Cystoisospora suis causes diarrhea and reduced weight gain in suckling piglets. Infections with C. suis occur in the first days of life; it is transient but can lead to dysbiosis, exacerbating disease and increasing mortality. Cystoisosporosis is effectively controlled by toltrazuril treatment; however, alterations of the gut microbial composition upon infection and treatment have not been investigated. This study evaluated the development of fecal microbiota of C. suis infected piglets in response to treatment with toltrazuril.Methods: Thirty-eight conventional piglets were infected with C. suis on the first day of life (dol 1). Twenty-six of them received either parenteral or oral toltrazuril two days later. Fecal samples were collected pre- and post-weaning (dol 1-15 and 31-38) for microbiota analysis using 16S rRNA amplicon sequencing and during dol 5-18 to determine fecal consistency and parasite excretion.Results: All piglets in the control group shed parasites at least once and the majority developed diarrhea, while toltrazuril-treated piglets did not excrete parasites and only had low levels of diarrhea. Age-related shifts in the fecal microbiota composition and increase in diversity and species richness were seen until after weaning. Infection with C. suis disrupted bacterial maturation two weeks after infection. Irrespective of the route of administration, fecal communities of piglets in the treated groups clustered separately and were more diverse compared to that of control piglets during the acute phase of infection on dol 11. Control piglet feces showed higher levels of Fusobacteriaceae and Veillonellaceae, while Ruminococcaceae, Lachnospiraceae, S24-7, Clostridiaceae and Erysipelotrichaceae were more abundant in feces of treated piglets on dol 11. After weaning, treatment-related effects on the microbial communities diminished and were presumably masked by changes associated with weaning.Conclusion: Irrespective of the administration route, toltrazuril prevented C. suis-related dysbiosis and maintained species richness and diversity on dol 11. In addition to cystoisosporosis prevention, toltrazuril seems to contribute to the stabilization of the gut microbial development during the suckling phase and thus may reduce the need for antibiotics to control infections with secondary bacterial enteropathogens in C. suis-infected suckling piglets.
Detection of Raised Intracranial Pressure in Craniosynostosis using Optical Coherence Tomography: A Systematic Review Protocol
Authors: Rufai Sohaib R , Jeelani Noor ul Owase , McLean Rebecca J 
Published: February 2020

Abstract
Introduction Craniosynostosis is characterised by the premature fusion of cranial sutures. This can be associated with raised intracranial pressure (ICP), which can lead to developmental delay, visual impairment and death. Treatment involves surgical expansion of the skull vault. There is no consensus over who to treat and when. Intracranial pressure is difficult to estimate in a child and existing methods possess sub-optimal diagnostic accuracy to be employed as screening tools. Here, we propose a systematic review protocol to examine the role of optical coherence tomography (OCT) in early detection of raised ICP in craniosynostosis. Methods Electronic searches in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and Embase will identify studies featuring OCT in detecting raised ICP in children with craniosynostosis. Two independent researchers will identify studies for inclusion using a screening questionnaire. Quality will be assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The primary outcome measure is the sensitivity and specificity of OCT in detecting raised ICP in children with craniosynostosis. Secondary outcomes measures include the sensitivity and specificity of other surrogate measures for raised ICP, OCT parameters used and normal ranges for ICP reported. A formal narrative synthesis with descriptive statistics will be presented. Discussion The proposed study will be the first to examine the role of optical coherence tomography in the early recognition of raised intracranial pressure in craniosynostosis, thereby addressing an important clinical problem in paediatric ophthalmology and craniofacial surgery. This systematic review protocol provides transparency to the proposed methods and reduces the possibility of duplication. The proposed methods reflect those prescribed by the Cochrane Collaboration. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO) number CRD42019147693