bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-disciplinary, multimodal approach for the management of vascular anomalies
Authors: Mazhar Aqsa , Moosa Shazia , Abbas Alizeh , Mallick Yousuf , Samad Lubna 
Published: November 2019

Objective: Vascular anomalies are a diverse group of lesions, ranging from simple to complex, disfiguring anomalies. Our objective was to diagnose and provide comprehensive treatment to patients presenting with vascular anomalies, using a multi-disciplinary approach involving dermatologists, plastic surgeons, radiologists and pediatric surgeons.
Methods: Patients presenting with vascular anomalies to The Indus Hospital, Karachi, from January 2017 to March 2019 were enrolled, using a pre-defined questionnaire. Assessment, diagnostic work up, management and clinical and photographic follow up was maintained to monitor outcomes.
Results: One hundred eighty seven patients with a mean age of 4.6 years, (females 62%) were enrolled. Diagnoses included vascular tumors (n=89, 47.6%), lymphatic malformations (n=38, 20.3%), capillary malformations (n=19, 10%), venous malformations (n=16, 8.5%), arterio-venous malformations (n=14, 7.5%) and mixed anomalies (n=11, 5.9%). Treatment modalities, in isolation or combination, included oral propranolol, topical timolol, pulsed dye laser and intra-lesional sclerotherapy. Mean follow up was in 7.1 months, with 27 patients achieving treatment completion. 26 children were lost to follow-up.
Conclusions: Vascular anomalies have mostly been managed successfully at VAC using single or multimodal treatment. Increasingly complex anomalies can be handled using a multi-disciplinary approach. Establishment of VAC has facilitated many patients who were earlier considered as diagnostic and therapeutic challenges.
doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1710
How to cite this:Mazhar A, Moosa S, Abbas A, Mallick Y, Samad L. A multi-disciplinary, multimodal approach for the management of vascular anomalies. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S14-S19. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1710
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Malaria and the climate in Karachi: An eight year review
Authors: Herekar Fivzia , Iftikhar Sundus , Nazish Ahsana , Rehman Sabeen 
Published: November 2019

Background and Objective: Malaria is an arthropod-borne infectious disease transmitted by the mosquito Anopheles and claims millions of lives globally every year. Reasons for failure to eradicate this disease are multifactorial. The seasonality of the malaria is principally determined by climatic factors conducive for breeding of the vector. We aimed to study the relationship between climatic variability and the seasonality of malaria over an eight-year duration.
Methods: This was a retrospective medical chart review of 8,844 confirmed cases of malaria which presented to The Indus Hospital, Karachi from January 2008 to November 2015. Cases were plotted against meteorological data for Karachi to elicit monthly variation.
Results: A secular incline and seasonality in malaria cases over the duration of 8 years was seen. More cases were reported in the summer, rainy season compared with the other three seasons in each year. There was significant association with specific climate variables such as temperature, moisture, and humidity.
Conclusion: There is a marked seasonal variation of malaria in Karachi, influenced by various environmental factors. Identification of the ‘the concentrated period’ of malaria can be helpful for policymakers to deploy malaria control interventions.
doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1712
How to cite this:Herekar F, Iftikhar S, Nazish A, Rehman S. Malaria and the climate in Karachi: An eight year review. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S33-S37. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1712
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The first experience of surgical treatment of obesity and metaboli desorders with using of minimally invasive technology
Authors: Staіkov P. , Kryvoruchko I. A. , Parkhomenko K. Yu. , Syvozhelіzov A. V. , Sykal M. , Smetskov D. A. , Tonkoglas A. A. 
Published: November 2019

The results of barіatrіc іnterventіons іn the clіnіc of the Department of Surgery No. 2 of the KhNMU wіth the use of mіnі-іnvasіve іnterventіons that were performed from September 2015: 7 patіents (3 women, 4 men) wіth morbіd obesіty (7) on the background of dіabetes mellіtus (1) at the age of 37-55 g. The weіght before operatіon was 125.75 [107-143] kg; BMІ - 46.3 [45.2-52.1] kg\m2. The followіng types of surgіcal іnterventіons were performed: іn 4 patіents laparoscopіc sleeve resectіon of the stomach; іn 3 laparoscopіc gastrіc bypass. All patіents began to eat and walk іn 4-6 hours after surgery. There were not complіcatіons and postoperatіve mortalіty. Patіents were dіscharged in a 7 days from the hospіtal. Tіme of observatіon is from 6 months to 3.5 years.Evaluatіon of the percentage of excess weіght loss (EWL %) was performed.The results are: on the averaged іn patіents undergoіng after gastrіc bypass: 1 months - 21%, sleeve gastrectomy (gastrіc sleeve resectіon): up to 1 months - on the average of 26,4%. The qualіty of patіents lіfe has іmproved sіgnіfіcantly.
The theoretical model of formation of readiness of future teachers of physical education in the organization of extracurricular activities on tourism
Authors: Chalii Liudmyla 
Published: November 2019

The article presents a theoretical model of readiness of the future teacher of physical education in the organization of extracurricular activities on tourism as a system of four interconnected blocks: conceptual, content, technological and effective - correctional. Conceptual block contains the purpose, a list of tasks, general scientific approaches and principles of teaching. The purpose of the article is to determine and justify the component model of readiness of the future teacher of physical education in the organization of extracurricular activities with tourism. Content block models constitute the professionally oriented and sports-pedagogical discipline.Technological block of model of readiness of the future teacher of physical education in the organization of extracurricular activities on tourism comprises the steps of the model realization (preparatory, operating, diagnostic - effective), pedagogical conditions of formation of readiness of the future teacher of physical education in the organization of extracurricular activities in tourism and technology of their implementation. Effective - correctional block contains the structural components (motivational - orientation, cognitive, practical and personal), criteria (axiological, epistemological, operational and integrational) and levels (high, medium, basic and low) of formation of readiness of the future teacher of physical education in the organization of extracurricular activities in tourism. Pedagogical conditions of formation of future teachers of physical education in the organization of extracurricular activities with tourism are identified as: formation of future physical education teachers’ motivational systems to implement extracurricular activities of tourism which are based on consideration of their individual psychological characteristics; strengthening of semantic saturation of the educational process of formation of future physical education in the organization of extracurricular activities in tourism by introducing a variable subject "The organization of extracurricular activities on tourism" and addition of the content of other disciplines with relevant modules; provision of modern information and methodological support of the educational process of formation of future physical education teachers for extracurricular activities in tourism.The set of components of the educational process, designed to ensure the implementation of the pedagogical conditions and to achieve the goal of forming the future teachers of physical education in the organization of extracurricular activities with tourism was justified.
TENSÕES ENTRE DESEJO E MORAL EM O ESPELHO DE GASTÃO CRULS
Authors: César André Gheti 
Published: November 2019

O presente artigo elabora uma análise do conto O Espelho de Gastão Cruls. Nesta análise, o ponto central seria o antagonismo existente entre os valores cultivados pelo protagonista e sua mulher e os desejos que os mesmos possuem. A fim de auxiliar a compreensão do conto, reflete-se sobre o duplo enquanto possibilidade de interpretação de textos literários. Neste conto, temos um duplo interior, onde o protagonista apresenta um conflito psíquico e uma cisão em seu âmago. Ainda no interior da temática do duplo e do conto, é também possível avaliar a presença de algumas oposições irreconciliáveis entre a espiritualidade e a corporeidade, o cristianismo e o paganismo, a virtude e o vício ou a repressão e a satisfação de impulsos sexuais. Ainda que apresente estas situações sem reconciliação, o conto de Cruls também indica que a emersão do outro não ocorre sem preconceitos e conflitos, mesmo que este estranho ao comum seja também próximo e familiar.
EDUCAÇÃO INFANTIL E SUBJETIVAÇÃO DA CRIANÇA NA SOCIEDADE DE CONSUMO
Authors: Quixadá Luciana Martins 
Published: November 2019

Resumo: Pretende-se problematizar sobre as condições de participação política da criança na sociedade de consumo, apontando o quanto a educação infantil tem a fazer para tornar-se uma via potencializadora que supere práticas de exclusão e de fragilidade dos laços sociais. Importa na atualidade uma discussão crítica sobre os ideais de uma cultura que desautoriza muitos dos seus membros, negando suas capacidades de realizar mudanças significativas em suas experiências cotidianas. Metodologicamente, análises bibliográficas pautadas na teoria crítica e histórico-cultural, articularam-se aos resultados de uma pesquisa de tese, visando refletir sobre a constituição da autonomia da criança em ambiente escolar na sociedade de consumo. Considerando a dinamicidade das relações e dos espaços sociais, a escola precisa se reinventar, injetando práticas pedagógicas que favoreçam junto à criança sua participação nos projetos coletivos e que fomentem sua capacidade criativa como forma de viabilizar seu desenvolvimento social e moral, bem como o exercício de sua cidadania. Palavras-chave: Criança. Sociedade. Educação. Abstract: It is intended to problematize on the conditions of political participation of the child in the consumer society, pointing out how much the child education has to do to become a potential way that overcomes practices of exclusion and fragility of the social bonds. A critical discussion of the ideals of a culture that disavows many of its members, denying their ability to make meaningful changes in their everyday experiences, is currently important. Methodologically, bibliographic analyzes based on critical and historical-cultural theory, were articulated to the results of a thesis research, aiming to reflect on the constitution of autonomy in children in school environment in the consumer society. Considering the dynamics of relationships and social spaces, the school needs to reinvent itself, injecting pedagogical practices that favor the child's participation in collective projects and that promote their creative ability as a way to enable their social and moral development, as well as the exercise of their citizenship.Keywords: Child. Society. Education.
REFLEXÕES SOBRE A MORTE E A SENESCÊNCIA
Authors: Ottoni Máximo Alessandro Mendes , Cardoso Antônio Dimas 
Published: November 2019

Resumo: O presente artigo tem por objetivo fomentar um debate acerca de temas polêmicos, que são pertinentes ao envelhecimento humano, mas que muitas vezes não são discutidos pela sociedade. Buscou-se, por meio de pesquisa bibliográfica, documental e de estudos empíricos, apresentar questões ligadas ao envelhecimento, à morte, à eutanásia e ao suicídio. Percebeu-se nesse estudo que, muitas vezes, alguns temas são considerados tabu, como é o caso da eutanásia, mas existem países como Holanda, Bélgica, Suíça e Colômbia em que esse procedimento já foi adotado e, em alguns casos, até mesmo regulamentado. Verificou-se neste trabalho que, muitas vezes, a morte não é o maior temor do ser humano, mas sim, o medo da perda da liberdade e do controle da sua própria vida. Apoio familiar, tratamento clínico e espiritualidade podem ser considerados grandes aliados na tentativa de se evitar o suicídio cometido por pessoas idosas.Palavras-chave: Envelhecimento. Morte. Eutanásia. Suicídio. Abstract: The purpose of this article is to promote a debate about controversial issues there are pertinent to human ageing, but which are not often discussed by the society. Through bibliographic research, documentary and empirical studies, we presented questions related to ageing, death, euthanasia and suicide. It has been noted in this study that some topics are often considered a taboo, such as euthanasia, but there are countries such as the Netherlands, Belgium, Switzerland and Colombia where this procedure has already been adopted and, in some cases, even regulated. It has been found in this work that death is often not the greatest fear of the human being, but rather the fear of loss of freedom and control of one's life. Family support, clinical treatments and spirituality can be considered to be great allies in trying to prevent suicide by older people.Keywords: Aging. Death. Euthanasia. Suicide.
Scales for assessing medication adherence in patients with hypertension
Authors: Chatziefstratiou Anastasia , Giakoumidakis Konstantinos , Fotos Nikolaos V , Baltopoulos George , Brokalaki Hero 
Published: November 2019

Background:the choice of the appropriate tool for assessing level of medication adherence is a significant barrier in scientific research.Aims:to translate into Greek and test the reliability of the Hill-Bone and A-14 scales among patients with hypertension. Also, to compare patients' responses in the Hill-Bone scale, A-14 scale and Morisky Medication Adherence Scale (MMAS).Methods:data collection occurred between February 2016 and March 2016 at a general hospital in Athens, Greece. The sample consisted of hypertensive patients (n=34) and non-hypertensive patients (n=34).Findings:the coefficient alpha in hypertensive patients was 0.76 for Hill-Bone, 0.64 for MMAS and 0.91 for the A-14 scale. In non-hypertensive patients, the Cronbach's alpha for MMAS was 0.81 and 0.78 for A-14. A statistically significant difference was found among the mean scores of the scales, whereas strong correlation was found only between two pairs of questions with similar meaning.Conclusion:all tools are appropriate to assess the level of medication adherence in Greek hypertensive patients. However, careful translation of the scales is essential since items with the same meaning could be understudied in a different way.
Analogue x digital: Parallel techniques for design learning
Authors: Matthews Linda , Donnelly Samantha 
Published: November 2019

Abstract
With urban space under the ubiquitous scrutiny of digital visioning technologies, the city is now imaged by means of a pixel grid containing ephemeral, qualitative data presented as colour, brightness and shape. Unlike traditional analogue pictorial representational modes, the digital image is a highly transformable mechanism with an unstable distribution of data across its pixel array. As a consequence, representation in the form of spatial abstraction demands not only a new approach to the learning and implementation of traditional disciplinary drawing practice, but a rethinking of the alignment and cooperative nature of analogue and digital drawing models when applied to effective design development. In a pedagogical context, the transition of spatial representation between analogue and digital modes has profound implications for how the student connects seminal drawing and design processes to both the sensorial realm and the physical experience of lived space. This paper therefore explores the enhancement of tertiary learning in digital and abstract literacy through new drawing techniques. Underpinned by a new relationship between representation and envisioned physical space, the techniques are applied within learning environments in parallel with existing analogue pictorial procedures. By building curriculum for foundational students that provides a framework of linked spatial experiences aligned across analogue and digital domains and coupled with tasks focused on the development of conceptual thinking, it proposes increased student success in future studios and professional practice.
Drawing out: Encounter, resistance and collaboration
Authors: Clancy Majella , Felmingham Stephen 
Published: November 2019

Abstract
This collaborative paper is written against the backdrop of a current crisis in art education and provision in UK secondary schools. Education policy and the introduction of the European Baccalaureate (EBacc) has led to an increasing decline in the hours of arts teaching and number of arts teachers in England's secondary schools (). The results of this educational turn are well documented and the effects are being felt now in higher education, in wider culture and in the outcomes for young people in their creative capabilities, global outlook and wellbeing. Drawing pedagogy is considered with reference to this wider context and through the lens of Gert Biesta's philosophy of education that brings children and young people into dialogue with the world. It juxtaposes Tim Ingold and John Dewey in a discussion of a collaborative drawing project, Ailleurs (Elsewhere), an exchange between Plymouth College of Art (PCA) and Ecole Supérieure des Beaux-Arts Montpellier Contemporain (MoCo ESBA) in 2017. The intention is to bring a pedagogy of collaboration, resistance and encounters to bear, to argue for drawing as a singular means of working within this set of tensions. The text concludes that as research or enquiry-led teaching is at the root of an increasing amount of University teaching, finding a route into this from results-led education is a clear challenge to higher education and it sets out a collaborative, peer-to-peer learning strategy as an approach to drawing pedagogy.
Efficacy of Sox10 Promoter Methylation in the Diagnosis of Intestinal Neuronal Dysplasia From the Peripheral Blood
Authors: Liu Yu-Rong , Ba Fang , Cheng Lan-Jie , Li Xu , Zhang Shi-Wei , Zhang Shu-Cheng 
Published: November 2019

OBJECTIVES:
Intestinal neuronal dysplasia (IND) is a common malformation of the enteric nervous system. Diagnosis requires a full-thickness colonic specimen and an experienced pathologist, emphasizing the need for noninvasive analytical methods. Recently, the methylation level of the Sox10 promoter has been found to be critical for enteric nervous system development. However, whether it can be used for diagnostic purposes in IND is unclear.

METHODS:
Blood and colon specimens were collected from 32 patients with IND, 60 patients with Hirschsprung disease (HD), and 60 controls. Sox10 promoter methylation in the blood and the Sox10 expression level in the colon were determined, and their correlation was analyzed. The diagnostic efficacy of blood Sox10 promoter methylation was analyzed by receiver operating characteristic curve.

RESULTS:
The blood level of Sox10 promoter methylation at the 32nd locus was 100% (90%–100%; 95% confidence interval [CI], 92.29%–96.37%) in control, 90% (80%–90%; 95% CI, 82.84%–87.83%) in HD, and 60% (50%–80%; 95% CI, 57.12%–69.76%) in IND specimens. Sox10 promoter methylation in the peripheral blood was negatively correlated with Sox10 expression in the colon, which was low in control, moderate in HD, and high in IND specimens (r = −0.89). The area under the curve of Sox10 promoter methylation in the diagnosis of IND was 0.94 (95% CI, 0.874–1.000, P = 0.000), with a cutoff value of 85% (sensitivity, 90.6%; specificity, 95.0%). By applying a cutoff value of 65%, promoter methylation was more indicative of IND than HD.

DISCUSSION:
The analysis of Sox10 promoter methylation in the peripheral blood can be used as a noninvasive method for IND diagnosis.
Mechanochemistry of von Willebrand factor
Authors: Lancellotti Stefano , Sacco Monica , Basso Maria , Cristofaro Raimondo De 
Published: November 2019

AbstractVon Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall. Hydrodynamic forces are responsible for extensive conformational transitions in the VWF multimers that change their structure from a globular form to a stretched linear conformation. This feature makes this protein particularly prone to be investigated by mechanochemistry, the branch of the biophysical chemistry devoted to investigating the effects of shear forces on protein conformation. This review describes the structural elements of the VWF molecule involved in the biochemical response to shear forces. The stretched VWF conformation favors the interaction with the platelet GpIb and at the same time with ADAMTS-13, the zinc-protease that cleaves VWF in the A2 domain, limiting its prothrombotic capacity. The shear-induced conformational transitions favor also a process of self-aggregation, responsible for the formation of a spider-web like network, particularly efficient in the trapping process of flowing platelets. The investigation of the biophysical effects of shear forces on VWF conformation contributes to unraveling the molecular mechanisms of many types of thrombotic and haemorrhagic syndromes.