bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiproxy approaches to investigating palaeoecology and palaeohydrology in the Upper Cretaceous Kaiparowits Formation, USA
Authors: Yamamura Daigo , Suarez Celina A. , Titus Alan L. , Manlove Hunter M. , Jackson Thea 
Published: December 2020

Abstract

The Late Campanian-aged Kaiparowits Formation (72.5–76.6 Ma) is a thick, fossiliferous fluvio-overbank–lacustrine complex deposited in south-central Utah. Host to one of the richest, most diverse Campanian terrestrial fossil records in North America, the physical environment of the Kaiparowits ecosystem, particularly the dynamics of the hydrological system, remains obscure. In 2014, an extensive bonebed was found in a conglomeratic sandstone unit of fluvial origin, known as the Rainbows and Unicorns Quarry. Isotopic compositions of serially sampled tooth enamel phosphate (δ
18
O
p
) from tyrannosaur teeth were analysed to see if they held data that could clarify the palaeohydrology of the Kaiparowits Formation. To assess a greater palaeoecological context for the tyrannosaurs, the isotopic composition of their teeth was compared to other faunal elements, including the giant alligatoroid
Deinosuchus
, and turtles (Baenid,
Gilmoremys
,
Neurankylus
and Trionychid) from the same quarry. The δ
18
O
w
calculated from tyrannosaur was low, suggesting that isotopically-light, high-altitude runoff strongly influenced the local hydrology of the Kaiparowtis Formation. The seasonal change in δ
18
O of tyrannosaur drinking water ranged from −21.0 to −14.4‰ V-SMOW, while δ
18
O
w
calculated from turtles and crocodiles ranged between an average of −9.3 and −10.9‰, respectively. The seasonal precipitation pattern and temperature of the Kaiparowits Formation was then compared to analogue settings, such as the monsoonal climate of Hanoi, Vietnam and Cuiaba, Brazil. While similarities exist between these sites, the unique configuration of the Sevier Mountains adjacent to the nearby Western Interior Seaway provides the unique setting for a complex palaeohydrological system that results in a wide range of δ
18
O
w
as a result of cold seasonal precipitation at high elevation that runs off and mixes with local precipitation (−6.0 to −4.68‰) sourced from the Western Interior Seaway. This study demonstrates the importance of serial- and micro-sampling of multi-taxa comparisons for isotopic investigations of palaeohydrological systems.
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT
Authors: Kryshtal Dmytro O. , Blackwell Daniel J. , Egly Christian L. , Smith Abigail N. , Batiste Suzanne M. , Johnston Jeffrey N. , Laver Derek R. , Knollmann Bjorn C. 
Published: December 2020

Rationale:
The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by hyperactive RyR2 (cardiac ryanodine receptor) mediated calcium (Ca) release. Although flecainide inhibits single RyR2 channels in vitro, reports have claimed that RyR2 inhibition by flecainide is not relevant for its mechanism of antiarrhythmic action and concluded that sodium channel block alone is responsible for flecainide’s efficacy in CPVT.

Objective:
To determine whether RyR2 block independently contributes to flecainide’s efficacy for suppressing spontaneous sarcoplasmic reticulum Ca release and for preventing ventricular tachycardia in vivo.

Methods and Results:

We synthesized N-methylated flecainide analogues (QX-flecainide and
N
-methyl flecainide) and showed that
N
-methylation reduces flecainide’s inhibitory potency on RyR2 channels incorporated into artificial lipid bilayers.
N
-methylation did not alter flecainide’s inhibitory activity on human cardiac sodium channels expressed in HEK293T cells. Antiarrhythmic efficacy was tested utilizing a Casq2 (cardiac calsequestrin) knockout (Casq2−/−) CPVT mouse model. In membrane-permeabilized Casq2−/− cardiomyocytes—lacking intact sarcolemma and devoid of sodium channel contribution—flecainide, but not its analogues, suppressed RyR2-mediated Ca release at clinically relevant concentrations. In voltage-clamped, intact Casq2−/− cardiomyocytes pretreated with tetrodotoxin to inhibit sodium channels and isolate the effect of flecainide on RyR2, flecainide significantly reduced the frequency of spontaneous sarcoplasmic reticulum Ca release, while QX-flecainide and
N
-methyl flecainide did not. In vivo, flecainide effectively suppressed catecholamine-induced ventricular tachyarrhythmias in Casq2−/− mice, whereas
N
-methyl flecainide had no significant effect on arrhythmia burden, despite comparable sodium channel block.

Conclusions:
Flecainide remains an effective inhibitor of RyR2-mediated arrhythmogenic Ca release even when cardiac sodium channels are blocked. In mice with CPVT, sodium channel block alone did not prevent ventricular tachycardia. Hence, RyR2 channel inhibition likely constitutes the principal mechanism of antiarrhythmic action of flecainide in CPVT.
Are Dalit Women Healers Allowed to Claim “Tradition”?
Authors: Ram Kalpana 
Published: December 2020

Abstract
This essay uses Dalit women’s mediumship as a healing tradition that provides something of a “limit situation” from which to review basic assumptions about the varied ways in which we can understand what it is to “have” tradition—as an acquisition and inheritance that Dalit women enjoy like everyone else, but also as formal claims to value and recognition that are largely denied to Dalit women. Comparing Dalit women healers with male performers in ritual theater and more privileged healers in rural Tamil Nadu, the essay addresses dimensions of inequality comparatively neglected in studies of tradition as either constructed or invented within modernity. The essay moves us away from discussions of tradition that center on conscious claims to a consideration of the elements that mean that some traditions may never reach the level of being articulated as claims, let alone achieve recognition.
The Longer Theology of Aristotle in al-Andalus
Authors: Treiger Alexander 
Published: December 2020

Abstract
The present article reports the discovery of previously unknown quotations from the Longer Theology of Aristotle (LThA), preserved in Lisān al-Dīn Ibn al-Khaṭīb’s (d. 776/1374) philosophical-mystical treatise Rawḍat al-taʿrīf bi-l-ḥubb al-sharīf (composed in Granada ca. 1366). The first of these quotations contains the famous ekstasis passage, which is not preserved in Judeo-Arabic. The second quotation has a close parallel in the Epistles of the Brethren of Purity (Ikhwān al-ṣafāʾ). An analysis of these quotations provides additional evidence to the transmission of LThA in Arabic characters. The Appendix provides an up-to-date inventory of the Judeo-Arabic manuscripts of LThA, complete quire analysis of manuscripts A and C, and a table of correspondences between the unpublished “MS Fenton,” Borisov’s references to LThA, and modern pagination.
Revisiting the Quasi-Biennial Oscillation as Seen in ERA5. Part I: Description and Momentum Budget
Authors: Pahlavan Hamid A. , Fu Qiang , Wallace John M. , Kiladis George N. 
Published: December 2020

AbstractThe dynamics and momentum budget of the quasi-biennial oscillation (QBO) are examined in ERA5. Because of ERA5’s higher spatial resolution compared to its predecessors, it is capable of resolving a broader spectrum of atmospheric waves and allows for a better representation of the wave–mean flow interactions, both of which are of crucial importance for QBO studies. It is shown that the QBO-induced mean meridional circulation, which is mainly confined to the winter hemisphere, is strong enough to interrupt the tropical upwelling during the descent of the westerly shear zones. Since the momentum advection tends to damp the QBO, the wave forcing is responsible for both the downward propagation and for the maintenance of the QBO. It is shown that half the required wave forcing is provided by resolved waves during the descent of both westerly and easterly regimes. Planetary-scale waves account for most of the resolved wave forcing of the descent of westerly shear zones and small-scale gravity (SSG) waves with wavelengths shorter than 2000 km account for the remainder. SSG waves account for most of the resolved forcing of the descent of the easterly shear zones. The representation of the mean fields in the QBO is very similar in ERA5 and ERA-Interim but the resolved wave forcing is substantially stronger in ERA5. The contributions of the various equatorially trapped wave modes to the QBO forcing are documented in Part II.
Evaluation of GPM Dual-Frequency Precipitation Radar (DPR) Rainfall Products Using the Rain Gauge Network over China
Authors: Gao Yang , Wu Tongwen , Wang Jun , Tang Shihao 
Published: December 2020

AbstractThe Dual-Frequency Precipitation Radar (DPR) on board the Global Precipitation Measurement (GPM) mission core satellite provides the new-generation global observation of rain since 2014. The main objective of this paper is to evaluate the suitability and limitation of GPM-DPR level-2 products over China. The DPR rain rate products are compared with rain gauge data during the summers of 5 years (2014–18). The ground observation network is composed of more than 50 000 rain gauges. The DPR precipitation products for all scans (DPR_NS, DPR_MS, and DPR_HS) generally underestimate rain rates. However, DPR_MS agrees better with gauge estimates than DPR_NS and DPR_HS, yielding the lowest mean error, systematic deviation, and highest Pearson correlation coefficient. In addition, all three swath types show obvious overestimation over gauge estimates between 0.5 and 1 mm h−1 and underestimation when gauge estimates are larger than 1 mm h−1. The DPR_HS and DPR_MS agree better with gauge estimates below and above 2.5 mm h−1, respectively. A deeper investigation was carried out to analyze the variation of DPR_MS’s performance with respect to terrains over China. An obvious underestimation, relative to gauge estimates, occurs in Tibetan Plateau while a slight overestimation occurs in the North China Plain. Furthermore, our comprehensive analysis suggests that in Sichuan Basin, the DPR_MS exhibit the best agreement with gauge estimates.
Role of Magnetic Resonance Imaging in Predicting Residual Breast Cancer After Vacuum-Assisted Breast Biopsy
Authors: Zheng Sun , Qi Liu , Guang-Qiang Zhang , Ming-Ming Shi , Chun-Hong Xu 
Published: December 2020

Purpose This study aims to evaluate the effectiveness of breast magnetic resonance imaging (MRI) in detecting residual breast cancer in patients after vacuum-assisted breast biopsy (VABB). Methods Between 2012 and 2019, 26 patients with breast cancer who underwent VABB were enrolled. Breast MRI was conducted after VABB. Imaging findings were then compared with the histopathological results. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Results Residual cancer was confirmed histologically in 8 of the 26 patients after VABB. The overall sensitivity, specificity, PPV, NPV, and accuracy of MRI for diagnosing residual cancer were 79.9%, 73.0%, 87.1%, 61.3%, and 77.8%, respectively. The sensitivity and NPV improved to 100%, when the number of biopsy specimens was larger than five. Conclusion Breast MRI showed high sensitivity and NPV in detecting residual breast tumor after VABB.
Clinical and Financial Implications of Consulting Physicians in the Management of Surgical Patients
Authors: Reza Joseph A. , Steve Eubanks W. , de la Fuente Sebastian G. 
Published: December 2020

Background The present study was designed to evaluate the immediate consequences that the number of consulting physicians has on length of stay (LOS), in-hospital mortality, 30-day readmission rates, direct health care costs, and contribution margins. Methods A retrospective review of administrative databases for the years 2013 and 2014 was performed at the Florida Hospital Adventist Healthcare System. Results 11 274 patients were included in the analysis. Total and variable costs increased by $1347 and $592, respectively, with each consulting physician service per patient. The contribution margin decreased by $354 per patient/consulting physician. Each consulting physician increased LOS by .72 days and increased odds ratio of mortality and 30-day readmission by 5% and 3%, respectively. Conclusions Our research suggests that each consulting physician added to the care of an individual surgical patient negatively affected LOS, readmission rates, in-hospital mortality, and costs.
A Handoff Protocol for Pediatric Trauma Patients at a Rural Level One Trauma Center Reduces Length of Stay
Authors: Coile Evelyn , Bailey Kathryn , Clayton Eric J. , Eversley Kelso Tatiana R. , MacNew Heather 
Published: December 2020

Background The management of the pediatric trauma patient is variable among trauma centers. In some institutions, the trauma surgeon maintains control of the patient throughout the hospital stay, while others transfer to a pediatric specialist after the initial evaluation and resuscitation period. We hypothesized that handoff to the pediatric surgeon would decrease the length of stay by more efficient coordination with pediatric subspecialists and ancillary staff. Methods A retrospective review from October 2014 to October 2018 was conducted at our rural level 1 trauma center analyzing the length of stay across all demographics and trauma triage levels before and after institution of a handoff protocol from adult specialized trauma surgeons to pediatric surgeons within a 24-hour window. Further analysis included emergency department (ED) disposition to include the effect of handoff on the length of stay in the setting of a higher post-ED acuity, that is, disposition of monitored beds. Results 1267 patient charts were analyzed and the mean length of stay was reduced by .38 days ( t = 5.92, P < .0005) across all demographics, trauma triage levels, post-ED dispositions, and mechanisms of injury after institution of our handoff protocol. Conclusion Handoff from adult specialized trauma surgeons to pediatric surgeons within a 24-hour window at a rural level 1 trauma center significantly improved the length of stay by .38 ( t = 5.92, P < .0005) among pediatric trauma patients in all demographics, trauma triage activations levels, mechanisms of injury, and post-ED dispositions acuity levels.
Racial and Sex Disparities in Trauma Outcomes Based on Geographical Region
Authors: Duong William Q. , Grigorian Areg , Farzaneh Cyrus , Nahmias Jeffry , Chin Theresa , Schubl Sebastian , Dolich Matthew , Lekawa Michael 
Published: December 2020

Objectives Disparities in outcomes among trauma patients have been shown to be associated with race and sex. The purpose of this study was to analyze racial and sex mortality disparities in different regions of the United States, hypothesizing that the risk of mortality among black and Asian trauma patients, compared to white trauma patients, will be similar within all regions in the United States. Methods The Trauma Quality Improvement Program (2010-2016) was queried for adult trauma patients, separating by U.S. Census regions. Multivariable logistic regression analyses were performed for each region, controlling for known predictors of morbidity and mortality in trauma. Results Most trauma patients were treated in the South (n = 522 388, 40.7%). After risk adjustment, black trauma patients had a higher associated risk of death in all regions, except the Northeast, compared to white trauma patients. The highest associated risk of death for blacks (vs. whites) was in the Midwest (odds ratio [OR] 1.30, P < .001). Asian trauma patients only had a higher associated risk of death in the West (OR 1.39, P < .001). Male trauma patients, compared to women, had an increased associated risk of mortality in all four regions. Discussion This study found major differences in outcomes among different races within different regions of the United States. There was also both an increased rate and associated risk of mortality for male patients in all regions. Future prospective studies are needed to identify what regional differences in trauma systems including population density, transport times, hospital access, and other trauma resources explain these findings.
Risk Factors for Appendiceal Cancer After Appendectomy
Authors: Stopenski Stephen J. , Grigorian Areg , Carmichael Joseph , Mills Steven , Brady Matthew , Dolich Matthew , Kuza Catherine M. , Nguyen Ninh T. , Nahmias Jeffry 
Published: December 2020

Background Appendiceal cancer (AC) is a rare malignancy usually diagnosed incidentally after appendectomy. Risk factors for AC are poorly understood. We sought to provide a descriptive analysis for patients with AC discovered after appendectomy for acute appendicitis (AA). Methods The 2016-2017 American College of Surgeons-National Surgical Quality Improvement Program Procedure-Targeted Appendectomy database was queried for adult patients who underwent appendectomy for image-suspected AA. Patients with pathology consistent with AA were compared to patients found to have AC. A multivariable logistic regression model was used for analysis. Results From 21 058 patients, 203 (1.0%) were found to have AC on pathology. Compared to patients with AA, patients with AC were older (median, 48 vs. 40 years old, P < .001). The AA group had a similar rate of perforated appendix compared to the AC group (16.3% vs. 13.4% P = .32). After adjusting for covariates, associated risk factors for AC were: age ≥65 years old (odds ratio (OR) 2.25, 1.5-3.38, P < .001), absence of leukocytosis (OR 1.58, 1.16-2.17, P = .004), and operative time ≥1 hour (OR 1.57, 1.14-2.16, P = .006). Gender, race, and history of smoking were not independent associated risk factors for AC. Conclusion The incidence of AC after appendectomy for suspected AA is approximately 1% in a large national analysis. These factors may be used to help identify patients at higher risk for AC after appendectomy.
Hernia Size and Mesh Placement in Primary Umbilical Hernia Repair
Authors: Tao Zoe , Ordonez Javier , Huerta Sergio 
Published: December 2020

Introduction Umbilical hernia repair (UHR) using mesh has been demonstrated to significantly reduce recurrence. However, many surgical centers still perform tissue repair for UH. In the present study, we assessed a cohort of veteran patients undergoing a standard open tissue repair for primary UH to determine at which size recurrence may preclude tissue repair. A systematic review of the literature on hernia size recommendations to guide mesh placement was performed. Methods A single-institution single-surgeon retrospective review of all patients undergoing open tissue repair of primary UH (n = 344) was undertaken at the VA North Texas Health Care System between 2005 and 2019. Guidelines for the preferred reporting items for systematic reviews and meta-analysis were undertaken for systematic review. Results A literature review yielded inconsistent guidance for a specific hernia size to proceed with tissue vs. mesh repair. Our institutional review yielded 17 (4.9%) recurrences. Univariable analysis demonstrated recurrence to be associated with hernia size (2.8 vs. 2.3 cm; P = .04). However, on multivariable analysis, hernia size was demonstrated as not an independent predictor of recurrence [OR 1.47 (95% CI; .97-2.21; P = .07)]. Conclusion A review of the literature suggests mesh placement most commonly when the hernia size is > 2.0 cm; however, sources of evidence are heterogeneous in study design, patient population, and hernia types studied. Our institutional review demonstrated that primary UHs < 2.3 cm can successfully be treated via tissue repair. Larger, recurrent, incisional, and primary epigastric hernias may benefit from mesh placement.
Suicide mortality in the United States following the suicides of Kate Spade and Anthony Bourdain
Authors: Sinyor Mark , Tran Ulrich S , Garcia David , Till Benedikt , Voracek Martin , Niederkrotenthaler Thomas 
Published: December 2020

Objective: The suicides of Kate Spade and Anthony Bourdain, two major American icons, in a span of days in June 2018 represent a unique and tragic natural experiment to characterize associations with actual suicides in the aftermath of celebrity suicides. The aim of this study was to identify changes in suicide counts after their deaths. Methods: Suicide data were obtained from the United States’ Centers for Disease Control and Prevention’s public-use mortality file. A time-series analysis was performed, examining monthly suicide data by age group (⩽19, 20–44, 45–64 and ⩾65 years), for both men and women, for all suicide methods and for hanging versus non-hanging methods, from January 1999 to December 2018. Seasonal autoregressive integrated moving-average models were fitted to the pre-June 2018 period, estimating suicides in subsequent months and identifying deviations from expected values. The volume of Twitter posts about Kate Spade and Anthony Bourdain was used as a proxy of societal attention. Results: Tweets about the celebrities were mainly concentrated in June 2018 and faded quickly in July. Total suicides exceeded the 95% confidence interval for June and approximated the upper limit of the 95% confidence interval in July. Over this 2-month span, there were 418 (95% confidence interval = [184, 652]) more suicides than expected, including 275 (95% confidence interval = [79, 471]) excess suicides in men and 182 (95% confidence interval = [93, 271]) in women. These equate to 4.8%, 4.1% and 9.1% increases above expected counts. There were 392 (95% confidence interval = [271, 514]) excess suicides by hanging, a 14.5% increase, with no significant increase in all other methods combined. Conclusion and Relevance: These findings demonstrate that mortality following celebrity suicides can occur at a similar magnitude to that observed for other public health emergencies. They underscore the urgency for interventions to mitigate imitation effects after celebrity suicide reporting.
Social representation of abuse of persons with severe mental illness in Jakiri, Cameroon: A qualitative study
Authors: Tanyuy Colins B , Aguocha Chinyere M , Nwefoh Emeka C , Wankam Mispar G 
Published: December 2020

Background: People with mental illness are vulnerable to abuse in the community. Cultural and social practices may be contributory. Aim: To explore the social representation of abuse of persons with mental illness among the inhabitants of Jakiri municipality in Cameroon. Method: This was a qualitative study based on the Theory of Reasoned Action, conducted in 2018 among 11 inhabitants of Jakiri municipality, aged above 18 years and who had lived in the town for at least 2 years. In-depth face-to-face semi-structured interviews were conducted. Data were analyzed using the basic thematic approach. Results: The belief that mental illness is incurable, a curse from the gods, a result of witchcraft, and a punishment for violation of core social norms were identified as the reasons for physical violence against persons with mental illness. Beliefs that persons with mental illness were disorganized, destructive, physically aggressive, and dependent on others were identified as reasons for emotional abuse. Conclusion: A misconception of mental illness was the major underlying factor for the abuse of persons with mental illness.