bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Family History and Knowing a Friend With Breast Cancer Predict Cancer Knowledge and Screening Practices? An International Study of Asian Women
Authors: Lee Chun Fan , Kwok Cannas , Lee Mi-Joung 
Published: February 2025

Background
Family history of breast cancer and social networks were found to have an influential effect on women’s cancer knowledge and screening practices. There is a scarcity of studies in this area among Asian populations.

Objective
This study aimed to explore the effect of family history and knowing a friend with breast cancer on Chinese and Korean women’s knowledge of breast cancer and screening practices.

Methods
A convenience sample of 742 women, comprising 493 and 249 Chinese and Korean women, respectively, was recruited. Data were collected by the Chinese and Korean version of the Breast Cancer Screening Beliefs Questionnaire. Multivariable linear regression was performed to answer the research question.

Results
Korean women with neither family history nor a friend history had significantly higher scores in all 3 subscales of the BCBSQ compared with their Chinese counterparts. In contrast, no significant differences were found between the 2 cohorts in women who have either family history or a friend history. Comparing within the Chinese cohort, women with a friend history obtained a significantly higher score in all 3 subscales of BCBSQ than those without a friend history. Similar significant association was found between having a friend history and screening practices in both cohorts.

Conclusion
Knowing a friend with breast cancer is an influential factor that impacts women’s cancer knowledge and screening practices.

Implications for Practice
The concept of peer influence should be incorporated into the design of breast cancer awareness and screening promotion programs for women from these cultural backgrounds.
Awareness, attitudes, and interest in doxyPEP as bacterial prophylaxis against sexually transmitted infections - New York City Sexual Health Clinics, June-August 2023
Authors: Leocadio Ciarra , Betancourt Gabriela , Tang Jennifer , Heth Zachary , Pathela Preeti 
Published: February 2025

Abstract

Background: Increased incidence of bacterial sexually transmitted infections including chlamydia, gonorrhea, and syphilis dictates the need for novel prevention strategies. One such strategy, doxycycline prescribed prophylactically, has proven to be effective at reducing transmission among men who have sex with men (MSM) and transgender women. We assessed awareness, attitudes, and interest in doxycycline pre-exposure/post-exposure prophylaxis (doxyPrEP/doxyPEP) among New York City (NYC) Sexual Health Clinic (SHC) patients, including MSM, other cisgender men, women, transgender persons, and patients identifying as gender non-conforming or non-binary.

Methods: A self-administered survey was completed by 280 patients from five NYC SHCs between June-August 2023 that collected information assessing their knowledge, concerns, and willingness to use doxyPrEP and doxyPEP. We used Poisson regression models to examine factors associated with willingness to use doxyPEP.

Results: Of the 280 patients, 73% (205) and 55% (153) reported they would take doxyPEP and doxyPrEP, respectively, if offered by their provider. Willingness to use doxyPEP was observed across gender groups and significantly associated with history or current use of HIV pre-exposure prophylaxis (adjusted risk ratio (aRR) 1.17, 95% CI: 1.07-1.27). Compared to non-Hispanic white participants, Hispanic (aRR 1.27, 95% CI: 1.07-1.52) and Non-Hispanic Other (Alaskan Native, American Indian, Native Hawaiian, Pacific Islander, multiracial) group (aRR 1.28, 95% CI: 1.06-1.56) participants were more likely to report willingness to use doxyPEP. Possible antibiotic resistance was of highest concern.

Conclusions: If offered by a provider, doxyPEP would likely be accepted by patients of all gender groups. Additional research on acceptability in other settings would help guide widespread implementation.
Estimation of Vitreous Chamber Volume Using Axial Length Measurements
Authors: Huang Yihong , Zhang Yan , Chen Wanzhu , Xiao Yanling , Huang Guangqian , Wu Yuyu , Cai Chi , Guo Maosheng 
Published: February 2025

Background:
Vitreous chamber volume (VCV) in humans can be accurately measured using magnetic resonance imaging (MRI) combined with ITK-SNAP analysis software. This study explores the relationship between VCV and axial length (AL).

Methods:
This study included 46 healthy individuals, encompassing a total of 92 eyes. Individuals with a history of eye conditions were excluded from the study. AL measurements were obtained using the Lenstar 900 (Haag-Streit, Switzerland). VCV was assessed through MRI using the Ingenia 3.0T system (Philips Medical Systems, Netherlands), with VCV analysis performed using ITK-SNAP analysis software version 3.8.0. The correlation between AL and VCV was evaluated using Pearson linear correlation coefficient, and a logistic regression model was employed to predict VCV.

Results:
The sample consisted of 92 eyes from 46 individuals, including 28 women and 18 men. The average VCV was 6193±1135.9 mm3 for women and 6324.3±886.7 mm3 for men. The mean AL for women was 24.70±2.78 mm, while for men it was 24.66±1.70 mm. A significant correlation between AL and VCV was observed (P<0.001).

Conclusions:
VCV can be accurately estimated through AL measurements, offering a clinically relevant method for assessing VCV.
3D Deep Learning for Virtual Orbital Defect Reconstruction: A Precise and Automated Approach
Authors: Yu Fangfang , Liu Chang , Zhong Chenglan , Zeng Wei , Chen Jinlong , Liu Wei , Guo Jixiang , Tang Wei 
Published: February 2025

Accurate virtual orbital reconstruction is crucial for preoperative planning. Traditional methods, such as the mirroring technique, are unsuitable for orbital defects involving both sides of the midline and are time-consuming and labor-intensive. This study introduces a modified 3D U-Net+++ architecture for orbital defects reconstruction, aiming to enhance precision and automation. The model was trained and tested with 300 synthetic defects from cranial spiral CT scans. The method was validated in 15 clinical cases of orbital fractures and evaluated using quantitative metrics, visual assessments, and a 5-point Likert scale, by 3 surgeons. For synthetic defect reconstruction, the network achieved a 95% Hausdorff distance (HD95) of<2.0 mm, an average symmetric surface distance (ASSD) of ∼0.02 mm, a surface Dice similarity coefficient (Surface DSC)>0.94, a peak signal-to-noise ratio (PSNR)>35 dB, and a structural similarity index (SSIM)>0.98, outperforming the compared state-of-the-art networks. For clinical cases, the average 5-point Likert scale scores for structural integrity, edge consistency, and overall morphology were>4, with no significant difference between unilateral and bilateral/trans-midline defects. For clinical unilateral defect reconstruction, the HD95 was ∼2.5 mm, ASSD<0.02 mm, Surface DSC>0.91, PSNR>30 dB, and SSIM>0.99. The automatic reconstruction process took ∼10 seconds per case. In conclusion, this method offers a precise and highly automated solution for orbital defect reconstruction, particularly for bilateral and trans-midline defects. We anticipate that this method will significantly assist future clinical practice.
Achieving Reliable Mastery of Emergency Airway Management Skills Through 4-Component Instructional Design
Authors: Gilic Fil , McGraw Robert , Newbigging Joseph , Blackmore Elizabeth , Stacey Matthew , Mercer Colin , Neufeld Troy , Johannessen Erika , Lam Wilson , Hall Ryan , Braund Heather 
Published: February 2025

Introduction
We used cognitive load theory to design the Queen's University Airway Mastery (QUMAC) pilot course to work toward reliable mastery of Emergency Airways Management elements in all participants.

Methods
We describe the process of designing QUMAC using 4-Component Instructional Design to harness the cognitive load theory as a learning tool. We evaluated the effectiveness of QUMAC using an outcome-based mixed-methods approach including Objective Structured Assessment of Technical Skills (OSATS) and 2 Objective Structured Clinical Examinations (OSCEs) at course completion using blinded expert video review. We also conducted semistructured interviews at course completion and after 6 months of independent practice. Interviews were analyzed thematically.

Results
Mean OSCE Global Performance Scores were 4.1 (±0.56) of 5 for both OSCE scores; and 4.0–4.4 (±0.48–0.89) on OSATS. At course completion, 4 themes were identified: Overall Experience with the Course, Facilitators of Performance, Recommendations, and Transfer to Practice. At 6 months of independent practice 5 themes emerged: Level of Confidence, Management of Cognitive Load, Persistence, Barriers to Application, and Recommendations

Conclusions
All participants demonstrated a high degree of competence when assessed by OSCEs and majority did so with the OSATS. All noticed an increase in confidence and reduced cognitive load while managing airways. These persisted over 6 months of independent practice where the participants were actively managing airways as staff physicians in new workplaces. High performance expectations, automation, schemas, spaced repetition, and homework were the elements most associated with better performance and more confidence. Decreased cognitive load freed up resources for higher order thinking, while the overall sense of competence reduced the anxiety of going to work as a new emergency department staff.
Venous thromboembolism events in trauma patients after hospital discharge
Authors: Dougherty Jacob M. , Gerhardinger Laura J. , Johnson Patrick L. , Regenbogen Scott E. , Scott John W. , Sangji Naveen F. , Jean Raymond A. , Hemmila Mark R. , Oliphant Bryant W. 
Published: February 2025

BACKGROUND
Venous thromboembolism (VTE) is common after major injury. This elevated VTE risk likely continues beyond hospital discharge, but a lack of postdischarge surveillance limits our understanding of this complication and opportunities for improving outcomes. We aimed to characterize the incidence and risk factors of trauma patients who developed a VTE in the first year after discharge from their index hospital admission.

METHODS
We used data from adult inpatients (18 years or older) from 35 American College of Surgeons - Committee on Trauma–verified Level 1 and Level 2 trauma centers in a statewide trauma quality improvement program from 2018 to 2023. The incidence and timing of a postdischarge VTE were identified from linked longitudinal insurance claims data, and multivariable logistic regression was performed to identify predictors of a postdischarge event.

RESULTS
Of 34,421 trauma registry and claims matched patients identified, 1,487 (4.3%) developed a VTE within the first year after discharge from the trauma center, compared with 280 VTE events (0.8%) diagnosed during the index admission. The incidence of VTE remained elevated well after discharge, with 40% occurring in the first 30 days and 73% within the first 3 months. Multiple patient, injury, and treatment factors were associated with postdischarge VTE risk, including having an operation, a significant spine injury, Black race, and receiving a blood transfusion.

CONCLUSION
The risk of VTE extends well beyond the index hospitalization for trauma patients, as the majority of events occur after discharge. Understanding and improving VTE outcomes in trauma patients will require a longitudinal patient record that captures these complications. Postdischarge VTEs are an underrecognized trauma-related morbidity but are also very treatable through a better understanding of the risk factors and the optimal prophylactic strategy.

LEVEL OF EVIDENCE
Prognostic and Epidemiologic; Level III.
Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy
Authors: Alsaadi Nijmeh , Younes Reem , Killinger Jack R. , Hoteit Lara , Puccio Ava M. , McIntyre Peyton , Raymond Olivia , Filicky Amanda , Hahner Thomas , Agnone Allison G. , Vincent Laura E. , Srinivasan Amudan , Zarisfi Mohammadreza , Dishong Devin M. , Abdullah Abiha , Arivudainambi Aishwarrya , Kar Ronit , Mihalko Emily P. , Loughran Patricia , Wisniewski Stephen R. , Luther James F. , Spinella Philip C. , Okonkwo David , Guyette Francis X. , Sperry Jason L. , Shea Susan M. , Neal Matthew D. 
Published: February 2025

INTRODUCTION
Traumatic brain injury (TBI) patients on antiplatelet therapy face higher mortality because of impaired platelet function, which may be treated by platelet transfusion. The value of testing platelet function in this cohort remains controversial. We aimed to evaluate the relationship between platelet function assays and outcomes in TBI patients on antiplatelet therapy receiving platelet transfusions. We hypothesized that the magnitude of change in platelet assay performance following a transfusion would predict meaningful clinical outcomes.

METHODS
A cohort of patients, aged 18 to 89 years, with a history of preinjury antiplatelet therapy or who required platelet transfusion, and who were deemed at risk for neurosurgical intervention, was selected from a prospective randomized controlled trial of platelet transfusion for TBI. Pre- and posttransfusion blood samples were drawn. Platelet hemostatic function assays (PHFAs) included thromboelastography with platelet mapping (TEG-PM) and VerifyNow. Logistic regression models assessed the association of temporal assay results with 30-day all-cause mortality, need for craniotomy, and initial and follow-up Rotterdam scores.

RESULTS
Data from 94 TBI patients (43% female) with a median age of 76 years were analyzed. The 30-day mortality rate was 14%. VerifyNow aspirin assay was able to capture increases in platelet function following a platelet transfusion in patients on aspirin (significant positive Δ = 65 aspirin response units, p < 0.001). Thromboelastography with platelet mapping parameters detected improved platelet function following transfusion, although the absolute value of changes was minimal. Thromboelastography with platelet mapping parameters predicted important clinical outcomes on logistic regression, although no significant associations with clinical outcomes were identified by the change in PHFA after transfusion or after adjusting for multiple comparisons.

CONCLUSION
Higher absolute pre- and posttransfusion values of TEG-PM were associated with decreased mortality, decreased need for neurosurgical intervention, and decreased risk of progression of hemorrhage in TBI patients taking antiplatelet agents, although neither the change in TEG-PM after transfusion nor any other PHFA value predicted outcomes.

LEVEL OF EVIDENCE
Prognostic and Epidemiological; Level III.
Who is being heard? Implementing change with people from diverse and marginalized groups in aged care: a scoping review
Authors: Marshall Amy , Windle Alice , Harvey Gill , Davy Carol 
Published: February 2025

ABSTRACT

Introduction:
Many older people belong to diverse and marginalized groups, with care needs and preferences outside of normative aged care services. Increasing the representation and contributions of these older people is central to an equity-sensitive implementation approach where adaptation to the context is critical.

Objective:
This review assessed the extent and nature of the literature on implementing change in aged care contexts serving older people who belong to diverse and marginalized groups.

Methods:
This scoping review searched for literature examining the implementation of change in any aged care context where older people from diverse and marginalized groups access care. The search was conducted in the PubMed, CINAHL, Scopus, and PsycINFO databases, and limited to papers published from 2013 onward. Of the 2,021 papers identified, 35 were included.

Results:
The majority (70%) of studies were in a residential aged care context, and only 25% used an implementation framework. Less than half (40%) engaged with diverse and marginalized older people or their representatives to understand their needs and preferences. The majority engaged instead with staff or other stakeholders, and most engagement (64%) was limited to lower-level consultation such as seeking feedback rather than involving, collaborating, or empowering stakeholders to ensure their perspectives improved the implementation process.

Conclusions:
There is little in the literature about ensuring changes in aged care identify and meet the needs and priorities of diverse and marginalized older people. This suggests a pressing need for implementation science to pay greater attention to equity and inclusion in the aged care context.

Spanish abstract:

http://links.lww.com/IJEBH/A314
We are the champions, my friend! Key considerations in selecting and supporting champions to promote implementation in aged care
Authors: Windle Alice , Marshall Amy , Harvey Gillian , Davy Carol 
Published: February 2025

Abstract

Introduction:
Champions are a well-recognized strategy for supporting the implementation of innovations in care settings, yet there is limited clear guidance to support their use in the particular context of aged care.

Aim:
This study aimed to identify key lessons for optimizing the use of champions as an implementation strategy in aged care settings.

Methods:
We conducted a secondary analysis of literature included in a recent scoping review on implementing innovations in aged care.

Results:
The individuals who acted as champions came from a variety of roles and disciplines. The functions performed by champions largely involved influencing others, as well as other activities such as facilitating, educating, enabling, and reinforcing implementation. Key characteristics of champions included being enthusiastic and well-regarded by others, as well as having empathy and appropriate skills and knowledge. Champions were reportedly challenged by resourcing issues such as high workload, staff turnover, and competing priorities. The support of leaders and peers, a clearly identified role, adequate training, and appropriate selection were identified as key to optimizing champions’ effectiveness.

Conclusions:
For champions to be an effective implementation strategy, the champions need to be carefully selected, appropriately trained, and well supported. These findings can inform approaches to optimize the use of champions for implementing innovations in aged care.

Spanish abstract:

http://links.lww.com/IJEBH/A318
A prognostic model for Senescence-related LncRNA in a novel colon adenocarcinoma based on WGCNA and LASSO regression
Authors: Huang Yichu , Min Guangtao , Wang Hongpeng , Jiang Lei 
Published: February 2025

AbstractObjectiveThis study aims to develop a prognostic model based on senescence-related long non-coding RNAs (lncRNAs) to predict the prognosis of patients with colon cancer and enhance their survival rates.MethodDifferential expression analysis and Pearson correlation were employed to identify senescence-related lncRNAs in colon cancer. A risk prognosis model was constructed using univariate Cox regression analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis. The reliability of this model was validated through survival analysis, receiver operating characteristic (ROC) curves, bar charts, and calibration curves. Additionally, the relationship between the prognostic model, immune microenvironment, and drug sensitivity was explored.ResultsA risk prognosis model comprising eight senescence-related lncRNAs (LINC02257, AL138921.1, ATP2B1-AS1, AC005332.7, AC007728.3, AC018755.4, AL390719.3, THCAT158) was successfully established, demonstrating strong performance in predicting the overall survival rates of colon cancer patients. A significant correlation was observed between the senescence-related lncRNA progn model and the tumor microenvironment, immune infiltrating cells, and drug sensitivity.ConclusionThe senescence-related lncRNA prognostic model developed in this study can accurately forecast the prognosis of colon cancer patients, offering new insights for personalized treatment approaches in colon cancer.
Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid
Authors: Hernandez Mariana Bravo , Mazur Curt , Chen Hao , Fradkin Linda , Searcy Justin , Burel Sebastien , Kelly Mackenzie , Bruening Dona , O’Rourke Jacqueline G. , Cai Yuhang , Nguyen Jonathon , Berman-Booty Lisa , Cummins Lendell , Gaus Hans , Powers Berit , Zhao Hien , Jafar-Nejad Paymaan , Henry Scott , Swayze Eric , Kordasiewicz Holly B. 
Published: February 2025

ABSTRACTOligonucleotide (ON) therapeutics are promising as a disease-modifying therapy for central nervous system disorders. Intrathecal ON administration into the cerebral spinal fluid is a safe and effective delivery mode to the CNS. However, preclinical studies have shown acute toxicities following high-dose central ON delivery. Here we characterize a transient neurobehavioral change peaking 15 minutes after ON dosing and resolving after 120 minutes. Symptoms include shaking, muscle twitching, cramping, hyperactivity, stereotypic movements, hyperreactivity, vocalizations, tremors, convulsions, and seizures. These are collectively referred here as the acute neuronal activation response. Acute neuronal activation is observed in rats, mice, and non-human primates and is quantifiable using a simple scoring system. It is distinct from acute sedation seen with some phosphorothioate-modified antisense oligonucleotides, characterized by loss of spinal reflexes, ataxia, and sedation. The acute neuronal activation response is largely sequence-independent and is driven by ON chelation of divalent cations, particularly influenced by the divalent cations-to-ON ratio in the dosing solution. Acute neuronal activation can be safely mitigated by adjusting this ratio through magnesium supplementation in the ON formulation. We provide a comprehensive framework for quantifying and mitigating the acute neuronal activation response caused by high concentrations of centrally delivered ON therapeutics in preclinical species.GRAPHICAL ABSTRACT
Top-down control of the descending pain modulatory system drives placebo analgesia
Authors: Livrizzi Giulia , Liao Jingzhu , Johnson Desiree A. , Lubejko Susan T. , Chang-Weinberg Janie , Dong Chunyang , Tian Lin , Banghart Matthew R. 
Published: February 2025

AbstractIn placebo analgesia, prior experience and expectations lead to pain suppression by the administration of an inert substance, but causal evidence for its neural basis is lacking. To identify the underlying neural circuits, we reverse-translated a conditioned placebo protocol from humans to mice. Surprisingly, the placebo effect suppresses both nociception and unconditioned emotional-motivational pain-related behavior. Descending pain modulatory neurons in the periaqueductal gray (PAG) are critical for both morphine and placebo antinociception. The placebo effect depends on input to the PAG from the medial prefrontal and anterior cingulate cortices, but not anterior insular cortex. Conditioning enhances noxious stimulus-evoked endogenous opioid release in the PAG to produce analgesia. Our results suggest that cortical control of the descending pain modulatory system (DPMS) is gated by rapid endogenous opioid signaling in the PAG during placebo trials. This study bridges clinical and preclinical research, establishing a central role for the DPMS in placebo analgesia.