bluuebunny/crossref_metadata_2025_split huggingface dataset:
The migration and preservation of six Norwegian municipality record‐keeping systems: Lessons learned
Authors: Soedring Thomas , Borlund Pia , Helfert Markus 
Published: December 2020

AbstractThis article presents a rare insight into the migration of municipality record‐keeping databases. The migration of a database for preservation purposes poses several challenges. In particular, our findings show that relevant issues are file‐format heterogeneity, collection volume, time and database structure evolution, and deviation from the governing standard. This article presents and discusses how such issues interfere with an organization's ability to undertake a migration, for preservation purposes, of records from a relational database. The case study at hand concerns six Norwegian municipality record‐keeping databases covering a period from 1999 to 2012. The findings are presented with a discussion on how these issues manifest themselves as a problem for long‐term preservation. The results discussed here may help an organization and Information Systems (IS) manager to establish a best practice when undertaking a migration project and enable them to avoid some of the pitfalls that were discovered during this project.
A broad analysis in clinical and in vitro models on regulator of G‐protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance
Authors: Kucuk Burak , Kibar Beyza , Cacan Ercan 
Published: December 2020

Ovarian cancer is one of the deadliest types of gynaecological cancers and more than half of the patients die within 5 years after diagnosis. Recurrence in advanced staged patients after chemotherapy is associated with increased chemoresistance, which results in poor prognosis. Regulator of G‐protein signalling 10 (RGS10) negatively regulates cell proliferation, migration and survival by attenuating G‐protein coupled‐receptors mediated signalling pathways. Recent studies have shown that loss of RGS10 expression is significantly associated with proliferation and cisplatin resistance in ovarian cancer cells.Significance of the studyIn this study, we analysed differential RGS10 expression levels using public microarray datasets from clinical and in vitro ovarian cancer samples. We validated that cancer progression and chemotherapy exposure change RGS10 expression. We enriched our study to evaluate the relationship between chemoresistance and differential RGS10 expression against ovarian cancer potential chemotherapeutic agent, palbociclib. Results showed that palbociclib treatment reduced cell viability, despite significantly decreased RGS10 expression in chemoresistant cells. Overall, the results confirmed that cancer progression and chemoresistance are significantly associated with the down‐regulation of RGS10 while some chemotherapeutics seem to be beneficial in decreasing chemoresistance in ovarian cancer.
Atypical presentation of Abiotrophia defectiva infective endocarditis in an octogenarian
Authors: Forde Gerard , Lucey Mary , O'Shea Paula M. , Okiro Julie , Shatwan Ramadan , Mulkerrin Eamon C. 
Published: December 2020

AbstractBlood cultures should be performed in non‐specifically unwell older adults following nonspecific presentations. Prompt diagnosis and commencement of targeted antimicrobial therapy are essential in older patients with A. defectiva IE.
COVID‐19 pneumonia in a patient with sarcoidosis: A case report
Authors: Ramdani Hanae , Benelhosni Khadija , Moatassim Billah Nabil , Nassar Ittimade 
Published: December 2020

AbstractKey prognostic elements to consider in sarcoidosis patients who contract COVID‐19 pneumonia are pulmonary involvement, the underlying immune system dysfunction, immunosuppressive therapies’ use, and the increased risk for hypercoagulability.
Comments on “Molecular Chirality in Classical Spacetime: Solving the Controversy about the Spinning Cone Model of Rotating Molecules”
Authors: Barron Laurence D. , Cintas Pedro 
Published: December 2020

AbstractA recent mathematical analysis by Michel Petijean aimed at solving the Barron/Mislow controversy concerning the chirality or otherwise of a non‐translating spinning cone concluded that both are right: the controversy is a matter of an arbitrary choice of a conversion factor. This reassessment highlights the different physicochemical properties of a stationary spinning cone and a chiral molecule and concludes that Petitjean's analysis is misleading.
Fragments‐Expert: A graphical user interface MATLAB toolbox for classification of file fragments
Authors: Teimouri Mehdi , Seyedghorban Zahra , Amirjani Fatemeh 
Published: December 2020

SummaryThe classification of file fragments of various file formats is an essential task in various applications such as firewalls, intrusion detection systems, antiviruses, web content filtering, and digital forensics. However, the community lacks a suitable software tool that can integrate major methods for feature extraction from file fragments and classification among various file formats. In this article, we present Fragments‐Expert that is a graphical user interface MATLAB toolbox for the classification of file fragments. It provides users with 23 categories of features extracted from file fragments. These features can be employed by seven categories of machine learning algorithms for the task of classification among various file formats.
Exploring CO2@sI Clathrate Hydrates as CO2 Storage Agents by Computational Density Functional Approaches
Authors: Cabrera‐Ramírez Adriana , Arismendi‐Arrieta Daniel J. , Valdés Álvaro , Prosmiti Rita 
Published: December 2020

AbstractThe formation of specific clathrate hydrates and their transformation at given thermodynamic conditions depends on the interactions between the guest molecule/s and the host water lattice. Understanding their structural stability is essential to control structure‐property relations involved in different technological applications. Thus, the energetic aspects relative to CO2@sI clathrate hydrate are investigated through the computation of the underlying interactions, dominated by hydrogen bonds and van der Waals forces, from first‐principles electronic structure approaches. The stability of the CO2@sI clathrate is evaluated by combining bottom‐up and top‐down approaches. Guest‐free and CO2 guest‐filled aperiodic cages, up to the gradually CO2 occupation of the entire sI periodic unit cells were considered. Saturation, cohesive and binding energies for the systems are determined by employing a variety of density functionals and their performance is assessed. The dispersion corrections on the non‐covalent interactions are found to be important in the stabilization of the CO2@sI energies, with the encapsulation of the CO2 into guest‐free/empty cage/lattice being always an energetically favorable process for most of the functionals studied. The PW86PBE functional with XDM or D3(BJ) dispersion corrections predicts a lattice constant in accord to the experimental values available, and simultaneously provides a reliable description for the guest‐host interactions in the periodic CO2@sI crystal, as well as the energetics of its progressive single cage occupancy process. It has been found that the preferential orientation of the single CO2 in the large sI crystal cages has a stabilizing effect on the hydrate, concluding that the CO2@sI structure is favored either by considering the individual building block cages or the complete sI unit cell crystal. Such benchmark and methodology cross‐check studies benefit new data‐driven model research by providing high‐quality training information, with new insights that indicate the underlying factors governing their structure‐driven stability, and triggering further investigations for controlling the stabilization of these promising long‐term CO2 storage materials.
Resolving Breakpoints of Chromosomal Rearrangements at the Nucleotide Level Using Sanger Sequencing
Authors: Nalbandian Katarena , Piña‐Aguilar Raul E. , Morton Cynthia C. 
Published: December 2020

AbstractNovel cytogenetic tools are increasingly based on genome sequencing for detecting chromosomal abnormalities. Different sequence‐based techniques optimized for diagnosis of structural variants can be useful for narrowing down the localization of breakpoints of chromosomal abnormalities, but do not offer nucleotide resolution of breakpoints for proper interpretation of gene disruption. This protocol presents the characterization of structural variants at nucleotide resolution using Sanger sequencing after low‐pass large‐insert genome sequencing or other long‐molecule methods. © 2020 Wiley Periodicals LLC.Basic Protocol 1: Primer design for junction amplification at translocations and inversionsBasic Protocol 2: Amplification of derivative chromosomes using a long‐range polymeraseAlternate Protocol: Amplification of derivative chromosomes using a hot‐start polymeraseBasic Protocol 3: Preparation of DNA for Sanger sequencingBasic Protocol 4: Interpretation and reporting of breakpoints based on Sanger sequencing
Highly Strained Nanoscale Bicyclophane Monolayers Entering the Third Dimension: A Combined Synthetic and Scanning Tunneling Microscopy Investigation
Authors: Henzel Sebastian , Becker Steven , Hennen Daniel , Keller Tristan J. , Bahr Joshua , Jester Stefan‐S. , Höger Sigurd 
Published: December 2020

AbstractTetrabromo aromatics can be synthesized by the Fischer‐Zimmermann condensation of appropriate pyrylium salts with arylene dicarboxylic acid salts. Their cyclization by intramolecular Yamamoto coupling yields strained bicyclophanes with adjustable sizes and different intraannular bridges. All compounds adsorb at the solid/liquid interface on highly oriented pyrolytic graphite (HOPG) and are investigated by scanning tunneling microscopy (STM) with submolecular resolution. The observed two‐dimensional (2D) supramolecular nanopatterns depend only on the sizes and alkoxy periphery of the cyclophanes and are independent of the specific structures of the intraannular bridges. Since the central arylene moieties of the smaller species are oriented perpendicular to the planes of the bicyclophanes, their substituents protrude from the surface by up to 1.6 nm after adsorption. Therefore, these molecules are attractive platforms for addressing the volume phase above the graphite surface.
Direct Oxidative Nitrogen Fixation from Air and H2O by a Water Falling Film Dielectric Barrier Discharge Reactor at Ambient Pressure and Temperature
Authors: Liu Zhuo , Tian Yonghui , Niu Guanghui , Wang Xu , Duan Yixiang 
Published: December 2020

AbstractCurrent industrial production of HNO3 relies on the Ostwald process via catalytic oxidation of NH3, which is responsible for the vast bulk of CO2 emission. An attractive alternative route to HNO3 is direct N2 oxidation to aqueous HNO3, which avoids the NH3 intermediate. Herein, we for the first time report a non‐thermal plasma‐assisted nitrogen fixation process characteristic of a large gas‐liquid contact based on the water falling film dielectric barrier discharge, wherein HNO3 is produced directly from ambient air and H2O at atmospheric pressure and room temperature without the presence of any catalytic material. By optimizing the plasma reaction conditions, a relatively high synthesis rate and low energy consumption was achieved at the same time with good product selectivity.
Variation cascades: resource pulses and top‐down effects across time scales
Authors: Simon Franz W. , Vasseur David A. 
Published: December 2020

AbstractTop‐down and bottom‐up theories of trophic control have been fundamental to our understanding of community dynamics and structure. However, most ecological theories have focused on equilibrium dynamics and do not provide predictions for communities’ responses in temporally fluctuating environments. By deriving the frequency response of populations in different trophic communities, we extend the top‐down and bottom‐up theories of ecology to include how temporal fluctuations in potential primary productivity percolate up the food chain and are re‐expressed as population variability. Moreover, by switching from a time‐based representation into the frequency domain, we provide a unified method to compare how the time scale of perturbations determines communities’ responses. At low frequencies, primary producers and secondary consumers have the highest temporal variability, while the primary consumers are relatively stable. Similar to the Exploitation Ecosystem Hypothesis, top‐down effects drive this alternating pattern of variability. We define the top‐down effect of consumers on the variability of lower trophic levels as a variation cascade. However, at intermediate frequencies, variation cascades can amplify temporal variation up the food chain. At high frequencies, variation cascades weaken, and fluctuations are attenuated up the food chain. In summary, we provide a novel theory for how communities will respond to fluctuations in productivity, and we show that indirect species interactions play a crucial role in determining community dynamics across the frequency spectrum.
Simulation analyses of stabilization control of power system frequency fluctuations resulting from wind farm output by gas turbine thermal power plant
Authors: Takahashi Rion , Umemura Atsushi , Tamura Junji , Kimura Mamoru , Hino Noriaki 
Published: December 2020

AbstractThis paper presents a basic study about the control ability of LNG thermal power plant driven by Motor‐assisting Gas Turbine (MGT) for frequency stabilization of power grid system. An analytical model of the regulation system with assisting motor and gas turbine is developed, and its performance for frequency stabilization under fluctuating power due to renewable energy sources is investigated by numerical simulation analyses.
Synthesis of Carbonyl‐substituted Tetracyanodihydrotetraaza[14]annulenes
Authors: Pawluczyk Konrad , Sanjuan‐Szklarz W. Fabiola , Woźniak Krzysztof , Kowalski Jarosław 
Published: December 2020

AbstractA number of novel tetracyano‐substituted dihydrotetraaza[14]annulene (DH‐TAA) analogues were obtained in a simple and convenient way by one‐pot synthesis. The ligands, as well as their complexes with nickel(II), copper(II) and palladium(II) ions were characterised, including X ray structures for seven compounds. The X‐ray analysis shows relatively short distances between tetraazamacrocyclic rings (3.0–3.3 Å), resulting from the presence of strong π‐π interactions. Moreover, some of synthesised compounds can easily be modified in order to attach commonly used reactive groups, which makes them very promising as future components of π‐interaction based supramolecular systems
Environmental impact and performance assessment of a new Zigbee‐based shotgun training system
Authors: Ben Ali Boubaker , Fraj Chawki , Oueslati Olfa , Dugas Éric 
Published: December 2020

AbstractOnly a few research works have studied the risks involving young athletes in shooting activities such as noise and risk of projectile impact. Besides, limited studies have explored the environmental concerns caused by remaining projectile fragments scattered into the environment. In recent years, there has been an increasing interest in integrating computing, modeling, and IoT‐based applications and used connected add‐ons (e.g., steams Virtual Reality VR, virtual guns, and game controllers) in sports activities displayed in virtual reality gaming environments. The aim of this paper is, first, to present a multi‐aspect Zigbee‐based protocol system used to assess and to improve reaction time and score prediction abilities of Shotgun sports practitioners indoor and outdoor. Second, B‐percept would be presented as a training solution to reduce environmental scattered wastes of used Clays. After 8 weeks of training, there was significant improvement (p < .001) of participants' reaction time by using the B‐percept simulator. In addition, improvement in real clay shotgun results (p < .0002) but it was difficult to correctly predict more than 60% of correct scores after the test. The results of this study encourage continuing to improve the B‐percept to use wireless moving targets for training purposes.
Geometry of obstacle marks at instream boulders—integration of laboratory investigations and field observations
Authors: Schlömer Oliver , Grams Paul E. , Buscombe Daniel , Herget Jürgen 
Published: December 2020

AbstractObstacle marks are instream bedforms, typically composed of an upstream frontal scour hole and a downstream sediment accumulation in the vicinity of an obstacle. Local scouring at infrastructure (e.g. bridge piers) is a well‐studied phenomenon in hydraulic engineering, while less attention is given to the time‐dependent evolution of frontal scour holes at instream boulders and their geometric relations (depth to width, and length ratio). Furthermore, a comparison between laboratory studies and field observations is rare. Therefore, the morphodynamic importance of such scour features to fluvial sediment transport and morphological change is largely unknown. In this study, obstacle marks at boulder‐like obstructions were physically modelled in 30 unscaled process‐focused flume experiments (runtime per experiment ≥ 5760 min) at a range of flows (subcritical, clear‐water conditions, emergent and submerged water levels) and boundary conditions designed to represent the field setting (i.e. obstacle tilting, and limited thickness of the alluvial layer). Additionally, geometries of scour holes at 90in‐situboulders (diameter ≥ 1 m) located in a 50‐km segment of the Colorado River in Marble Canyon (AZ) were measured from a 1 m‐resolution digital elevation model. Flume experiments reveal similar evolution of local scouring, irrespective of hydraulic conditions, controlled by the scour incision, whereas the thickness of the alluvial layer and obstacle tilting into the evolving frontal scour hole limit incision. Three temporal evolution phases—(1) rapid incision, (2) decreasing incision, and (3) scour widening—are identified based on statistical analysis of spatiotemporal bed elevation time series. A quantitative model is presented that mechanistically predicts enlargement in local scour length and width based on (1) scour depth, (2) the inclination of scour slopes, and (3) the planform area of the frontal scour hole bottom. The comparison of field observations and laboratory results demonstrates scale invariance of geometry, which implies similitude of processes and form rather than equifinality.
“You Were Gonna Leave Them Out?”: Locating Black Women in a Transfeminist Anthropology of Religion
Authors: Pérez Elizabeth 
Published: December 2020

AbstractThis article summons a transfeminist anthropology of religion and asserts that such an orientation (with a subfield to match) would be impossible to conceptualize without the scholarship of Black women—feminist, Womanist, and otherwise critically situated. Through the ethnographic analysis of interviews, documentary footage, newspaper reportage, social media, and videos, the article pays tribute to the late Reverend BobbieJean Baker (1964‐2014). The article argues that Black transgender Christian women's religious subjectivity encompasses the innovative inhabitation of Black ecclesiastical linguistic codes and gestural idioms; the elaboration of transfeminist biblical hermeneutics and discursive mechanisms of legitimation; and the simultaneous performance of culinary and relational virtuosity. The article further contends that Baker's account of her subjectivity cannot be understood without the insights of Christina Sharpe, Hortense J. Spillers, Monica A. Coleman, Yvette A. Flunder, Savannah Shange, Geneva Smitherman, Psyche A. Williams‐Forson, and Karen Baker‐Fletcher. Together, they assist in revealing that Baker's efforts to increase the livability of trans women's worlds were inseparable from her religious convictions, as communicated through (and constituted by) the discourses of the Black church. Equally so, her ministerial vocation and vision of beloved community proceeded from her experience as a seasoned—and expertly seasoning—southern‐born‐and‐raised Black trans woman.
Synthesis and Biological Studies of O3‐Aryl Galactosides as Galectin Inhibitors
Authors: Kervefors Gabriella , Pal Kumar Bhaskar , Tolnai Gergely L. , Mahanti Mukul , Leffler Hakon , Nilsson Ulf J. , Olofsson Berit 
Published: December 2020

Abstractβ‐Galactose derivatives have recently been reported to selectively inhibit galectin‐3, and a library of O3‐arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3‐arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3‐trifluoroethylated galactoside was also synthesized using iodonium salt chemistry. Azido‐substituted products were subsequently transformed into the corresponding triazoles. After deprotection, a selection of galactoside derivatives were evaluated for inhibitory potencies against galectins‐1, 3, 4 N (N‐terminal domain), 4 C (C‐terminal domain), 7, 8 N, 8 C, 9 N, and 9 C and one compound with promising affinity and selectivity for both the N‐ and C‐terminal domain of galectin‐9 was discovered.
Association between changes in mammographic density category and the risk of breast cancer: A nationwide cohort study in East‐Asian women
Authors: Kim Soyeoun , Park Boyoung 
Published: December 2020

AbstractBreast density is strongly associated with breast cancer risk; however, studies on the association between density changes and breast cancer risk have controversial results. The aim of our study was to determine the association between breast density changes and breast cancer risk in East‐Asian women. We included 3 301 279 women aged ≥40 years screened for breast cancer twice during 2009 to 2010 and 2011 to 2012. Data were obtained from the National Health Insurance Service (NHIS) database. Breast density was evaluated using the Breast Imaging‐Reporting and Data System (BI‐RADS). Relative risk (RR) and 5‐year risk of developing breast cancer according to density category changes were calculated. Overall, 23.0% of the women had a higher breast density and 22.2% of the women had a lower breast density in second screening compared to the first. An increase in the BI‐RADS density category between two subsequent mammographic screenings was associated with an increase in breast cancer risk and vice versa in terms of RR. The 5‐year breast cancer risk was affected by the initial BI‐RADS density category, changes in density category and patients' characteristics such as age, menopausal status and family history of breast cancer. In patients with breast cancer family history, the 5‐year breast cancer risk was prominent, at a maximum of 2.39% (95% CI = 1.23‐3.55) in women with breast density category of 2 to 4. Changes in the BI‐RADS density category were associated with breast cancer risk. Longitudinal measures of BI‐RADS density may be helpful in identifying high‐risk women, especially those with a breast cancer family history.