bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Hypernatremia and Angiotensin II by the Organum Vasculosum of the Lamina Terminalis Regulates Thirst
Authors: Kinsman Brian J. , Simmonds Sarah S. , Browning Kirsteen N. , Wenner Megan M. , Farquhar William B. , Stocker Sean D. 
Published: January 2020

The organum vasculosum of the lamina terminalis (OVLT) contains NaCl-sensitive neurons to regulate thirst, neuroendocrine function, and autonomic outflow. The OVLT also expresses the angiotensin II (AngII) type1 receptor, and AngII increases Fos expression in OVLT neurons. The present study tested whether individual OVLT neurons sensed both NaCl and AngII to regulate thirst and body fluid homeostasis. A multifaceted approach, includingin vitrowhole-cell patch recordings,in vivosingle-unit recordings, and optogenetic manipulation of OVLT neurons, was used in adult, male Sprague Dawley rats. First, acute intravenous infusion of hypertonic NaCl or AngII produced anatomically distinct patterns of Fos-positive nuclei in the OVLT largely restricted to the dorsal cap versus vascular core, respectively. However,in vitropatch-clamp recordings indicate 66% (23 of 35) of OVLT neurons were excited by bath application of both hypertonic NaCl and AngII. Similarly,in vivosingle-unit recordings revealed that 52% (23 of 44) of OVLT neurons displayed an increased discharge to intracarotid injection of both hypertonic NaCl and AngII. In marked contrast to Fos immunoreactivity, neuroanatomical mapping of Neurobiotin-filled cells from bothin vitroandin vivorecordings revealed that NaCl- and AngII-responsive neurons were distributed throughout the OVLT. Next, optogenetic excitation of OVLT neurons stimulated thirst but not salt appetite. Conversely, optogenetic inhibition of OVLT neurons attenuated thirst stimulated by hypernatremia or elevated AngII but not hypovolemia. Collectively, these findings provide the first identification of individual OVLT neurons that respond to both elevated NaCl and AngII concentrations to regulate thirst and body fluid homeostasis.SIGNIFICANCE STATEMENTBody fluid homeostasis requires the integration of neurohumoral signals to coordinate behavior, neuroendocrine function, and autonomic function. Extracellular NaCl concentrations and the peptide hormone angiotensin II (AngII) are two major neurohumoral signals that regulate body fluid homeostasis. Herein, we present the first compelling evidence that individual neurons located in the organum vasculosum of the lamina terminalis detect both NaCl and AngII. Furthermore, optogenetic interrogations demonstrate that these neurons play a pivotal role in the regulation of thirst stimulated by NaCl and AngII. These novel observations lay the foundation for future investigations for how such inputs as well as others converge onto unique organum vasculosum of the lamina terminalis neurons to coordinate body fluid homeostasis and contribute to disorders of fluid balance.
Depression, anxiety and stress among patients with hematological malignancies and the association with quality of life: a cross-sectional study
Authors: Papathanasiou Ioanna V , Kelepouris Konstantinos , Valari Chrisoula , Papagiannis Dimitrios , Tzavella Foteini , Kourkouta Lambrini , Tsaras Konstantinos , Fradelos Evangelos C. 
Published: January 2020

Αim. To evaluate psychological distress and quality of life of patients with hematological malignancies, as well as to identify the prognostic factors that aggravate their condition.
Methods. A cross-sectional, descriptive study including 87 patients with Hematological Malignancies was conducted. Data were collected with an anonymous questionnaire consisted by A) a sheet with socio-demographic characteristics, B) the Depression, Stress and Stress Scale (DASS21), and C) World Health Organization Life Quality Scale (WHOQOL - BREF30). The processing and statistical analysis of the empirical material of the research were done using the SPSS (Statistical Package for Social Science) 22.0.
Results. The results showed that the age of the sample averaged 71.22 years (SD = 8.71). Regarding their marital status, single mothers were 9.2%, married 62.1%. With regard to disease-related features, 28.7% of patients had Hodgkin's Lymphoma, 27.6% Chronic Lymphocytic Leukemia, 27.6% MDL and 16.1% of patients had myelodysplastic syndrome Multiple myeloma. In the investigation of the relationship between the Mental health Scale and the Quality of Life, negative correlations of Depression, Stress, Stress and the total DAS Scale with all dimensions of Patient Quality of Life were found.
Conclusions. Higher levels of psychological distress and poor mental health are associated with a low level of quality of life.
Distinguishing Children’s Hospitals From Non–Children’s Hospitals in Large Claims Data
Authors: Piper Kaitlin N. , Baxter Katherine J. , McCarthy Ian , Raval Mehul V. 
Published: January 2020

BACKGROUND:
The first methodologic step needed to compare pediatric health outcomes at children’s hospitals (CHs) and non–children’s hospitals (NCHs) is to classify hospitals into CH and NCH categories. However, there are currently no standardized or validated methods for classifying hospitals. The purpose of this study was to describe a novel and reproducible hospital classification methodology.

METHODS:
By using data from the 2015 American Hospital Association survey, 4464 hospitals were classified into 4 categories (tiers A–D) on the basis of self-reported presence of pediatric services. Tier A included hospitals that only provided care to children. Tier B included hospitals that had key pediatric services, including pediatric emergency departments, PICUs, and NICUs. Tier C included hospitals that provided limited pediatric services. Tier D hospitals provided no key pediatric services. Classifications were then validated by using publicly available data on hospital membership in various pediatric programs as well as Health Care Cost Institute claims data.

RESULTS:
Fifty-one hospitals were classified as tier A, 228 as tier B, 1721 as tier C, and 1728 as tier D. The majority of tier A hospitals were members of the Children’s Hospital Association, Children’s Oncology Group, and National Surgical Quality Improvement Program–Pediatric. By using claims data, the percentage of admissions that were pediatric was highest in tier A (88.9%), followed by tiers B (10.9%), C (3.9%), and D (3.9%).

CONCLUSIONS:
Using American Hospital Association survey data is a feasible and valid method for classifying hospitals into CH and NCH categories by using a reproducible multitiered system.
An Update on the Burden of Neonatal Abstinence Syndrome in the United States
Authors: Ramphul Kamleshun , Mejias Stephanie Gonzalez , Joynauth Jyotsnav 
Published: January 2020

OBJECTIVES:
To provide an estimate on the most recent burden of neonatal abstinence syndrome (NAS) in the United States.

METHODS:
The 2016 Kids’ Inpatient Database, provided by the Healthcare Cost and Utilization Project and Agency for Healthcare Research and Quality and its partners, was used to identify patients with NAS in the United States. The data consisted of pediatric admissions from 4200 US hospitals recorded between January 1, 2016, and December 31, 2016. Data were converted to weighted form to project a national estimate on the possible number of neonates affected by NAS. Differences in sex, race, location, household income, primary payer form, length of stay, and total charges were studied.

RESULTS:
The sample contained 32 128 patients with NAS (0.8%), among whom 17 164 (53.5%) were boys and 14 935 (46.5%) were girls (P &lt; .001); 23 027 (80.4%) were white (P &lt; .001), and 13 583 (42.3%) were from the southern parts of the United States (P &lt; .001). Medicaid covered 83.8% of patients, and 40.2% had an income within the first quartile of national averages (P &lt; .001). The overall mean and median length of stay were 16.45 and 12.00 days, respectively, and the mean and median total charges were calculated as $79 937.75 and $38 537.00, respectively. The total charges of NAS were $2 549 098 822.

CONCLUSIONS:
The incidence of NAS is on a constant rise; the number of cases rose from 21 732 in 2012 to 32 128 in 2016. Hospital charges have also tripled over the last 7 years to $2.5 billion in 2016.
Association of Cough Status With Bacterial Infections in Febrile Infants
Authors: Klouda Timothy M. , Wang Hongyue , Yaeger Jeffrey P. 
Published: January 2020

OBJECTIVES:
To examine the association between cough status and bacterial infections (BIs) to more accurately stratify risk and predict BIs in febrile infants.

METHODS:
A retrospective cohort study was performed by identifying all infants ≤60 days old with temperature ≥38°C at an urban pediatric emergency department from 2014 to 2016. The Rochester Risk model was used to stratify risk. Cough status (with or without) was the main covariate of interest. The primary outcome was a BI, including urinary tract infection, bacteremia, or meningitis. Analyses consisted of descriptive statistics, simple and multiple regression to compare the odds of BI on the basis of cough status, as well as χ2 statistics to compare the BI rates among high-risk infants with and without cough.

RESULTS:
Of 508 febrile infants ≤60 days old, 46 (9.1%) had a BI, 13 of which were either bacteremia or meningitis. There were no BIs among low-risk infants with a cough. The odds of BI increased progressively, peaking at 14.6 (95% confidence interval: 4.3–49.7) for high-risk infants without a cough. The adjusted odds of BI among infants with cough was 0.47 (95% confidence interval: 0.22–0.99).

CONCLUSIONS:
In our findings, an inverse relationship is demonstrated between presence of cough and odds of BI, suggesting that cough status may be a useful marker of viral infections in febrile infants. Considering that detecting cough status is noninvasive, inexpensive, and immediately available, it represents an attractive value-based risk factor to enhance current BI prediction models.
Comparison of mean squared error estimators under the Fay-Herriot model: application to poverty and percentage of food expenditure data
Authors: SHİFERAW Yegnanew A , GALPİN Jacqueline 
Published: January 2020

Small area estimates have received much attention from both private and public sectors due to the growing demand for effective planning of health services, apportioning of government funds and policy and decision making. The uncertainty of empirical best linear unbiased predictor (EBLUP) estimates is widely assessed by mean squared error (MSE). MSEs are criticized as they are not area specific since they do not depend on the direct estimators from the survey. In this paper, we compare the performances of different MSE estimators with respect to the relative bias and relative risk using a Monte Carlo simulation study. Simulation results suggest the superiority of the proposed MSEs over the existing methods in some situations. As a case study, the 2010/11 household consumption expenditure survey (HCES) and the 2007 housing and population census of Ethiopia have been used to study the performances of the MSE estimators.
What about the Interior Castle? Response to Ienca's and Andorno's New Human Rights in the Age of Neuroscience and Neurotechnology
Authors: Nawrot Oktawian 
Published: January 2020

Co z wewnętrzną twierdzą? Odpowiedź na propozycję Ienca i Andorno dotyczącą nowych praw człowieka w erze neuronauki i neurotechnologii
Zaproponowane przez Ineca i Andorno, w artykule „Towards new human rights in the age of neuroscience and neurotechnology”, trzy nowe prawa człowieka na pierwszy rzut oka wydają się niezwykle atrakcyjną odpowiedzią na rosnące ze strony neuronauki zagrożenia dla ludzkiej wolności. Jednakże ich głębsza analiza, zwłaszcza w kontekście zasad systemu ochrony praw człowieka Rady Europy, wraz z jego kamieniem węgielnym – przyrodzoną ludzką godnością, ujawnia szereg poważnych wątpliwości. Najpoważniejsza z nich dotyczy możliwości pogodzenia stojącej u podstaw neuronauki i neurotechnologii filozofii, wraz z milcząco przyjmowaną w ramach niej wizją człowieka, z filozofią praw człowieka i jej antropologią. Druga, bardziej szczegółowa, lecz równie istotna z punktu widzenia systemu wartości demokratycznego państwa prawnego, wątpliwość dotyczy kwestii pogodzenia nieterapeutycznych ingerencji w „wewnętrzną twierdzę” jednostki – mózg wraz z nadbudowanym nad nim umysłem – z obowiązkiem poszanowania i zabezpieczenia przez państwo prawa do wolności myśli, sumienia i religii, rozumianego zarówno jako fundamentalne prawo człowieka, jak i konstytutywny element systemu wartości demokratycznego państwa prawnego.
A gestão dos dados de pesquisa no âmbito da comunidade dos pesquisadores vinculados aos programas de pós-graduação brasileiros na área da Ciência da Informação: desvendando as práticas e percepções associadas ao uso e reuso de dados | The management of research data within the community of researchers linked to Brazilian post-graduate programs in the area of Information Science: unveiling the practices and perceptions associated with the use and reuse of data
Authors: Dias Guilherme Ataíde , Dos Anjos Renata Lemos , De Araújo Débora Gomes 
Published: January 2020

RESUMO A pesquisa investigou as práticas e percepções associadas com a gestão de dados pelos pesquisadores na pós-graduação brasileira na área da Ciência da Informação (CI). O instrumento de pesquisa utilizado foi um questionário semiestruturado, enviado por e-mail para 341 pesquisadores vinculados aos programas de pós-graduação brasileiros em CI. Os dados obtidos foram analisados através de técnicas de estatística descritiva e análise temática. Verificou-se que as práticas de gestão de dados conduzidas pelos pesquisadores precisam ser aprimoradas e que eles possuem postura favorável com relação ao compartilhamento de dados, desde que exista algum controle formal sobre os mesmos.Palavras-chave: Dados de Pesquisa; Compartilhamento de Dados de Pesquisa; Ciência da Informação; Tecnologia da Informação.ABSTRACT The research investigated the practices and perceptions associated with data management by researchers in Brazilian postgraduate programs in the Information Science (IC) area. A semi-structured survey was used as the research instrument, it was sent by e-mail to 341 researchers linked to the Brazilian postgraduate programs in CI. The data was analyzed through descriptive statistics techniques and thematic analysis. It was found that the data management practices conducted by the researchers need to be improved and that they have a favorable approach regarding data sharing, provided there is some formal control over them.Keywords: Research Data; Research Data Sharing; Information Science; Information Technology.
Práticas e percepções dos pesquisadores brasileiros sobre serviços de acesso aberto a dados de pesquisa | Practices and perceptions of Brazilian researchers on open access to research data
Authors: Caregnato Sonia Elisa , Vanz Samile Andrea de Souza , Pavão Caterina Groposo , Passos Paula Caroline Jardim Schifino , Borges Eduardo , Gabriel Junior Rene Faustino , Azambuja Luis Alberto , Da Rocha Rafael Port 
Published: January 2020

RESUMO O artigo apresenta análise exploratória das práticas e das percepções a respeito do acesso aberto a dados de pesquisa embasada em dados coletados por meio de survey, realizada com pesquisadores brasileiros. As 4.676 respostas obtidas demonstram que, apesar do grande interesse pelo tema, evidenciado pela prevalência de variáveis relacionadas ao compartilhamento e ao uso de dados e aos repositórios institucionais, não há clareza por parte dos sujeitos sobre os principais tópicos relacionados. Conclui-se que, apesar da maioria dos pesquisadores afirmar que compartilha dados de pesquisa, a disponibilização desses dados de forma aberta e irrestrita ainda não é amplamente aceita.Palavras-chave: Dados Abertos de Pesquisa; Compartilhamento de Dados; Reuso de Dados.ABSTRACT This article presents an exploratory analysis of the practices and perceptions regarding open access to research data based on information collected by a survey with Brazilian researchers. The 4,676 responses show that, despite the great interest in the topic, evidenced by the prevalence of variables related to data sharing and use and to institutional repositories, there is no clarity on the part of the subjects on the main related topics. We conclude that, although the majority of the researchers share research data, the availability of this data in an open and unrestricted way is not yet widely accepted.Keywords: Open Research Data; Data Sharing; Data Reuse.
Modelo de Maturidade para Repositórios Digitais: um caminho para sua adoção na gestão de dados de pesquisa | Digital Repositories Maturity Model: a way to its adoption in Research Data Management
Authors: Ribeiro Claudio José Silva 
Published: January 2020

RESUMO O acesso aberto à produção em Ciência e Tecnologia vem impulsionando os debates sobre a adoção e uso de instrumentos para compartilhamento da produção científica. Este relato propõe um modelo de maturidade que trata de forma integrada os repositórios confiáveis de documentos e os repositórios de dados, formando a noção de repositório digital integrado, para posicionar a instituição em um nível de maturidade para estes instrumentos de compartilhamento da produção científica. Apresenta o estudo sobre modelos de maturidade como forma de avaliação da qualidade para repositórios. Adota o modelo CMMI como referência, relacionado os respectivos níveis. Apresenta um estudo sobre repositórios confiáveis e critérios de avaliação, finalizando a proposta com a inclusão dos princípios FAIR no processo de avaliação. Fazendo uso de uma combinação de métodos para desenvolvimento da investigação, propõe a avaliação da qualidade de repositórios do estado do Rio de Janeiro segundo o modelo elaborado. Propõe a consolidação dos resultados em um modelo de avaliação estruturado em níveis de maturidade, incluindo um método de avaliação para repositórios integrados.Palavras-chave: Modelo de Maturidade; Repositório Digital; Gestão da Qualidade; Ciência Aberta; Repositório Confiável; Princípios FAIR.ABSTRACT Open access to research outcomes and data obtained in Science and Technology production has risen debates about the adoption and use of sharing tools for those outcomes. This research proposes a maturity model that unifies trusted document repositories and data repositories to form a notion of an integrated digital repository, setting this institution on a maturity level regarding these scientific production sharing tools. It also presents studies on these maturity models as ways to evaluate the quality of those data repositories. It adopts the CMMI model as a reference, relating to its respective levels. It presents a study on trustworthy repositories and evaluation criteria and concludes with the incorporation of FAIR principles into the evaluating process. Using a combination of methods to develop its investigation, the research proposes the use of this maturity model to evaluate Rio de Janeiro state repositories. Finally, it proposes the consummation of its results using an evaluation scheme structured in maturity levels, which includes an evaluation method for integrated repositories.Keywords: Maturity Model; Digital Repository; Quality Management; Open Science; Trustworthy Repository; FAIR Principles.
Identifikasi penyebab penyakit busuk bulir bakteri pada tanaman padi (Oryza sativa) dan pengendaliannya menggunakan isolat Bacillus spp. secara in vitro
Authors: Isnaeni Siti Juli , Masnilah Rachmi 
Published: January 2020

Bacterial grain rot disease in rice plant is a new disease in Indonesia. The disease can reduce rice production up to 40% in severe disease attack. Morphological and physiological identification of these pathogens can be useful as a strategy of disease control. Control of this disease using Agent Biological Control is a right step and eco-friendly. The research was conducted in July until November 2018 at Plant Quarantine Laboratory of Agricultural Quarantine Center Surabaya. Design of experiment used on pathogenic identification is descriptively and analytically while in strategy of diseases control used are Randomized Complete Design method of single factor as many as 5 treatment of Bacillus spp. such as; Ba1: Bacillus spp. isolate 1, Ba2: Bacillus spp. isolate 2, Ba3: Bacillus spp. isolate 3, Ba4: Bacillus spp. isolate 4, and Ba5: Bacillus isolate spp. 5. Research result showed that the pathogen causing bacterial grain rot in Rice is Burkholderia glumae with bacterial characteristic are Gram negative, aerobic, not fluorescent on Kings B medium, mesophyll, isotonic, can hydrolysis arginine and can produce enzyme of gelatinase and (2) Bacillus spp. Isolate which consistent to inhibiting B. glumae in vitro is Ba-1 with a mean inhibition of 17.88 mm and a variety of resistance mechanisms, namely bacteriostatic and bactericidal Isolate of Bacillus spp
Keywords: Bacterial grain rot rice; Bacillus spp; Burkholderia glumae
Penerapan Job Safety Analysis, Pengetahuan Keselamatan dan Kesehatan Kerja terhadap Kejadian Kecelakaan Kerja di Laboratorium Perguruan Tinggi
Authors: Abidin Azham Umar , Ramadhan Iqbal 
Published: January 2020

Kasus kecelakaan di Indonesia setiap tahunnya meningkat, data terkahir tahun 2018 sejumlah 157.313 kasus kasus kecelakaan kerja. Laboratorium tidak lepas dari potensi bahaya atau bahkan risiko kecelakaan kerja dari alat dan bahan praktikum bagi praktikan. Upaya untuk mencegah dan meminimalisir kecelakaan kerja di laboratorium dengan menerapkan Job Safety Analysis (JSA) dan meningkatkan pengetahuan Keselamatan dan Kesehatan Kerja (K3). Mengetahui penerapan JSA, pengetahuan K3 terhadap kejadian kecelakaan kerja di laboratorium perguruan tinggi. Jenis penelitian ini kuantitatif, metode observasional analitik dengan menggunakan desain cross sectional dan sample pada penelitian ini adalah 165 responden yang memiliki kriteria inklusi dan eksklusi. Hasil uji statistik antara penerapan JSA dengan kejadian kecelakaan kerja diperoleh p-value 0,063. Hal ini menunjukan tidak ada hubungan yang signifikan antara penerapan JSA dengan kejadian kecelakaan kerja. Begitu pula dengan pengetahuan K3 dengan kejadian kecelakaan kerja diperoleh p-value 0,266. tidak ada hubungan yang signifikan antara pengetahuan K3 dengan kejadian kecelakaan kerja. Meskipun secara statistik kedua varibel tersebut tidak ada hubungan yang signifikan, akan tetapi penerapan JSA merupakan upaya untuk mencegah dan meminimalisir kejadian kecelakaan kerja bagi praktikan dan pengetahuan K3 sebagai dasar pemahaman dan praktik penerapan bekerja di laboratorium.