bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milk quality, production process and physicochemical characteristics of Porungo, an artisanal cheese from the state of Sao Paulo, Brazil
Authors: Nogueira Silva Naaman Francisco , Siqueira de Aguiar Ketilin , Pimentel Filho Natan de Jesus , de Paula Ferreira Iuri Emmanuel , Lanzoni Troiani Caetano Afonso , Artigiani Lima Tribst Alline , Fernandes de Carvalho Antônio 
Published: December 2020

AbstractPorungo is a traditional pasta filata cheese produced using raw milk throughout the southwest region of the state of São Paulo, Brazil. The objectives of this Research Communication were to evaluate the quality of raw milk used to make Porungo cheese, to characterize its production process, and to determine its chemical composition. The results showed that the raw milk met both Brazilian and international quality requirements. Chemically, Porungo can be classified as a medium to full fat semi-hard fresh cheese. Our study has allowed the first standards and regulations for Porungo to be established in Brazil. By virtue of this, the local producers are able to formalize their activity while consumers can have access to a safe and certified product.
Group transdiagnostic cognitive-behavior therapy for anxiety disorders: a pragmatic randomized clinical trial
Authors: Roberge Pasquale , Provencher Martin D. , Gaboury Isabelle , Gosselin Patrick , Vasiliadis Helen-Maria , Benoît Annie , Carrier Nathalie , Antony Martin M. , Chaillet Nils , Houle Janie , Hudon Catherine , Norton Peter J. 
Published: December 2020

AbstractBackgroundTransdiagnostic group cognitive-behavioral therapy (tCBT) is a delivery model that could help overcome barriers to large-scale implementation of evidence-based psychotherapy for anxiety disorders. The aim of this study was to assess the effectiveness of combining group tCBT with treatment-as-usual (TAU), compared to TAU, for the treatment of anxiety disorders in community-based mental health care.MethodsIn a multicenter single-blind, two-arm pragmatic superiority randomized trial, we recruited participants aged 18–65 who met DSM-5 criteria for principal diagnoses of generalized anxiety disorder, social anxiety disorder, panic disorder, or agoraphobia. Group tCBT consisted of 12 weekly 2 h sessions. There were no restrictions for TAU. The primary outcome measures were the Beck Anxiety Inventory (BAI) and clinician severity rating from the Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5) for the principal anxiety disorder at post-treatment, with intention-to-treat analysis.ResultsA total of 231 participants were randomized to either tCBT + TAU (117) or TAU (114), with outcome data available for, respectively, 95 and 106. Results of the mixed-effects regression models showed superior improvement at post-treatment for participants in tCBT + TAU, compared to TAU, for BAI [p < 0.001; unadjusted post-treatment mean (s.d.): 13.20 (9.13) v. 20.85 (10.96), Cohen's d = 0.76] and ADIS-5 [p < 0.001; 3.27 (2.19) v. 4.93 (2.00), Cohen's d = 0.79].ConclusionsOur findings suggest that the addition of group tCBT into usual care can reduce symptom severity in patients with anxiety disorders, and support tCBT dissemination in routine community-based care.
Précis of Vigor: Neuroeconomics of Movement Control
Authors: Shadmehr Reza , Ahmed Alaa A. 
Published: December 2020

Abstract
Why do we run toward people we love, but only walk toward others? Why do people in New York seem to walk faster than other cities? Why do our eyes linger longer on things we value more? There is a link between how the brain assigns value to things, and how it controls our movements. This link is an ancient one, developed through shared neural circuits that on one hand teach us how to value things, and on the other hand control the vigor with which we move. As a result, when there is damage to systems that signal reward, like dopamine and serotonin, that damage not only affects our mood and patterns of decision-making, but how we move. In this book, we first ask why, in principle, evolution should have developed a shared system of control between valuation and vigor. We then focus on the neural basis of vigor, synthesizing results from experiments that have measured activity in various brain structures and neuromodulators, during tasks in which animals decide how patiently they should wait for reward, and how vigorously they should move to acquire it. Thus, the way we move unmasks one of our well-guarded secrets: how much we value the thing we are moving toward.
Two hundred days of COVID-19 in São Paulo State, Brazil
Authors: de Almeida Gabriel Berg , Pronunciate Micheli , Grotto Rejane Maria Tommasini , Azevedo Pugliesi Edmur , Guimarães Raul Borges , Vilches Thomas Nogueira , Mendes Coutinho Renato , Catão Rafael de Castro , Ferreira Claudia Pio , Fortaleza Carlos Magno Castelo Branco 
Published: December 2020

Abstract
Two hundred days after the first confirmed case of COVID-19 in Brazil, the epidemic has rapidly spread in metropolitan areas and advanced throughout the countryside. We followed the temporal epidemic pattern at São Paulo State, the most populous of the country, the first to have a confirmed case of COVID-19, and the one with the most significant number of cases until now. We analysed the number of new cases per day in each regional health department and calculated the effective reproduction number (Rt) over time. Social distance measures, along with improvement in testing and isolating positive cases, general population mask-wearing and standard health security protocols for essential and non-essential activities, were adopted and impacted on slowing down epidemic velocity but were insufficient to stop transmission.
Combined Rastelli procedure with supra-coronary ascending aorta replacement
Authors: Arora Yatin , Devagourou Velayoudam , Kar Tanushree 
Published: December 2020

AbstractWe present a 5-year-old child with pulmonary atresia palliated at infancy with midline shunt now for complete repair with aneurysmally dilated aorta. Patient underwent a combined Rastelli procedure with supra-coronary ascending aorta replacement with hemi-arch repair. Patient was discharged on post-operative day 10 and was asymptomatic on follow-up.
Incidence and impact of acute kidney injury in patients with hypoplastic left heart syndrome following the hybrid stage 1 palliation
Authors: Cunningham Tyler W. , Tan Yubo , Krawczeski Catherine D. , Spencer John D. , Bai Shasha , Phelps Christina , Yates Andrew R. 
Published: December 2020

AbstractObjective:Acute kidney injury leads to worse outcomes following paediatric cardiac surgery. There is a lack of literature focusing on acute kidney injury after the Hybrid stage 1 palliation for single ventricle physiology. Patients undergoing the Hybrid Stage 1, as a primary option, may have a lower incidence of kidney injury than previously reported. When present, kidney injury may increase the risk of post-operative morbidity and mortality.Methods:A retrospective, single centre review was conducted in patients with hypoplastic left heart syndrome who underwent Hybrid Stage 1 from 2008 to 2018. Acute kidney injury was defined as a dichotomous yes (meeting any injury criteria) or no (no injury) utilising two different criteria utilised in paediatrics. The impact of kidney injury on perioperative characteristics and 30-day mortality was analysed.Results:The incidence of acute kidney injury is 13.4–20.7%, with a severe injury rate of 2.4%. Patients without a prenatal diagnosis of hypoplastic left heart syndrome have a higher incidence of kidney injury than those prenatally diagnosed, (40% versus 14.5%, p = 0.024). Patients with acute kidney injury have a significantly higher incidence of 30-day mortality, 27.3%, compared to without, 5.6% (p = 0.047).Discussion:The incidence of severe acute kidney injury after the Hybrid Stage 1 palliation is low. A prenatal diagnosis may be associated with a lower incidence of kidney injury following the Hybrid Stage 1. Though uncommon, severe acute kidney injury following Hybrid Stage 1 may be associated with higher 30-day mortality.
Density of outdoor food and beverage advertising around gathering place for children and adolescent in East Java, Indonesia
Authors: Puspikawati Septa Indra , Dewi Desak Made Sintha Kurnia , Astutik Erni , Kusuma Dian , Melaniani Soenarnatalina , Sebayang Susy Katikana 
Published: December 2020

AbstractObjective:To survey outdoor food and beverage advertisements (‘F&B adverts’) for products that may be a risk factor for obesity, diabetes and CVD located in the vicinity of gathering places for children and adolescents.Design:We recorded the GPS coordinates of all F&B adverts visible from the streets at distances of 0–100, 100–300 and 300–500 m from facilities often used by children and adolescents. Those for unhealthy foods and beverages were identified. The density (number per square kilometre) of such advertisements was calculated and evaluated using hotspot analysis.Setting:The sub-districts Mulyorejo and Sukolilo in Surabaya city and the sub-districts Banyuwangi and Giri in Banyuwangi District, Indonesia.Participants:None.Results:The proportion of all outdoor advertisements that were F&B adverts was slightly higher in Banyuwangi than in Surabaya. Of the 570 F&B adverts recorded in Banyuwangi, 227 (39·8 %) and 273 (47·9 %) were for unhealthy foods and beverages, respectively. Of 960 F&B adverts in Surabaya, 271 (28·2 %) and 445 (46·3 %) were for unhealthy foods and beverages. In both regions, F&B advert density increased near gathering places for children and adolescents; all recreational areas had at least one set of advertisements for unhealthy beverages and food at 100–300 and 300–500 m. Both regions had one hotspot with significantly high numbers of unhealthy advertisements; Banyuwangi had one cold spot with a significantly low number of healthy advertisements.Conclusion:Regulations to control advertisements for unhealthy foods and beverages in areas frequented by children and adolescents are urgently needed.
Collection, characterization, conservation and utilization of Cordia sinensis Lam.: An underexploited multipurpose fruit species of hot arid regions
Authors: Dev Rahul , Sureshkumar M. , Kumar Sushil , Venkatesan K. , Singh Traloki , Tetarwal Arvind Singh , Patidar Anil , Dayal Devi , Meghwal P. R. 
Published: December 2020

AbstractCordia sinensis, locally known as ‘Goondi’ in India, is an underexploited multipurpose fruit species found in hot arid regions that is well adapted to drought, salt and hot conditions. The present study was undertaken to collect fruit samples from different locations in the Kachchh region of Gujarat, India, and to determine their field establishment for characterization, conservation and utilization. The maximum distribution of the species was observed in Bhuj (45%) and Mandvi (25%). Field boundaries (35%) and scrub forests (30%) had greater frequencies, whereas backyards had rarer frequencies (10%). The species most commonly occurred on levelled topography (60%) with a soil pH in the range of 8–8.5 (63%). Morphological data of three-year-old plants in the field gene bank showed a maximum coefficient of variation in the number of leaves per plant (66.6), followed by the number of branches per plant (45.62) and collar diameter (27.69). Wide variations were recorded in plant height (121.67–212 cm), spread (118–223 cm2) and the number of branches per plant (6–24.33). Specific accessions were identified for fodder (CBCG-12, CBCG-13 and CBCG-16), early flowering and fruiting (CBCG-12, CBCG-13 and CBCG-14), easier propagation by seeds (CBCG-12 and CBCG-13) and salt tolerance (CBCG-15 and CBCG-16). Preliminary findings and information provided about this species' utilization and other aspects might be useful for future research on its domestication, sole plantation and conservation aspects, improving the exploitation of this species by present and future generations.
TWO ARGUMENTS AGAINST THE GENERIC MULTIVERSE
Authors: MEADOWS TOBY 
Published: December 2020

AbstractThis paper critically examines two arguments against the generic multiverse, both of which are due to W. Hugh Woodin. Versions of the first argument have appeared a number of times in print, while the second argument is relatively novel. We shall investigate these arguments through the lens of two different attitudes one may take toward the methodology and metaphysics of set theory; and we shall observe that the impact of these arguments depends significantly on which of these attitudes is upheld. Our examination of the second argument involves the development of a new (inner) model for Steel’s multiverse theory, which is delivered in the Appendix.
Simulating and Evaluating Global Aerosol Distributions With the Online Aerosol‐Coupled CAS‐FGOALS Model
Authors: Wang Hao , Dai Tie , Goto Daisuke , Bao Qing , He Bian , Liu Yimin , Takemura Toshihiko , Nakajima Teruyuki , Shi Guangyu 
Published: December 2020

AbstractWe implement an existing aerosol module named Spectral Radiation Transport Model for Aerosol Species (SPRINTARS) in the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System (CAS‐FGOALS) model and simulate the global aerosol properties over 2002–2014. The simulated surface mass concentrations of individual aerosols generally reproduce the observed ones. The simulated spatial‐temporal distributions of the aerosol optical depths (AODs) are evaluated with multisource satellite retrievals, and the simulated AOD, Ångström Exponent (AE), and single scattering albedo (SSA) are further evaluated with the ground‐based Aerosol Robotic Network (AERONET) measurements. The spatial distribution of the modeled AOD is found to be generally comparable to the satellite retrievals. The interannual and seasonal variations of the modeled AOD over various aerosol regimes are also overall consistent with the AERONET observations. With respect to the AE, our model can reproduce the interannual variations fairly well over the dust dominant regions, and generally capture the seasonal variations over the industrial domain regions. Over the industrial domain regions, however, the systematic underestimation of the simulated AE is found, which is in part due to the biases of wind fields and overestimation of the relative humidity (RH) by the host model. With respect to the SSA, our model can also generally reproduce the observed seasonal variations, while the modeled values are typically lower than the observations, especially over North Africa.
Crustal Strain Patterns Associated With Normal, Drought, and Heavy Precipitation Years in California
Authors: Kim Jeonghyeop , Bahadori Alireza , Holt William E. 
Published: December 2020

AbstractWe invert continuously operating Global Positioning System (cGPS) data obtained between 2007 and 2019 to quantify non steady‐state horizontal strain anomalies in California. Our long‐wavelength transient strain model shows seasonal and multiannual variations in horizontal strain anomalies within the plate boundary zone. During the summer, in general, a zone of extensional dilatation develops along the San Andreas Fault zone and Sierra Nevada, whereas contractional dilatation develops along the Eastern California Shear Zone (ECSZ) north of 36.5°N. The patterns of dilatational strain are opposite during the winter. We find that these seasonal strain anomaly patterns vary in magnitude, depending on precipitation intensity in California. Investigating hydrologic loading models and their horizontal elastic responses reveal that water mass loads on the surface from the precipitation in California are the major sources of the observed long‐wavelength horizontal transient strains. We show, however, that a heavy damping in the inversion of the cGPS data is required for the long‐wavelength horizontal strain solutions to best match with the expected elastic response from hydrologic loading. Appropriate fitting of the horizontal cGPS yields amplified horizontal strain signals in the Sierra Nevada, along regions adjacent to the San Andreas Fault, and within the ECSZ. The larger‐than‐expected amplitudes may be associated with poroelastic responses or thermoelastic changes that are superimposed on the hydrologic response. We demonstrate that there is a persistent sharp boundary of horizontal dilatational strain domains at the transition between the High Sierra and Basin and Range Province, caused by the sharp gradient in hydrologic loading there.
Contrasting Aerosol Effects on Long‐Wave Cloud Forcing in South East Asia and Amazon Simulated With Community Atmosphere Model Version 5.3
Authors: Wang Minqi , Peng Yiran , Liu Yangang 
Published: December 2020

AbstractAerosols modify cloud microphysical and radiative properties and thus impact the shortwave and long‐wave cloud forcing (LWCF). This study first reports the finding of contrasting aerosol effects on LWCF in South East Asia and Amazon in the Community Atmosphere Model version 5.3 (CAM5.3), which corresponds to the sum of LW indirect and semi‐direct effects investigated in Ghan et al. (2012, http://doi.org/10.1175/jcli-d-11-00650.1). A series of numerical experiments are conducted to decompose the complex aerosol effects on LWCF. Our analysis indicates that the cooling (negative aerosol effects on LWCF) in Amazon is due mainly to the aerosol effects on warm clouds and the inhibition of vertical motion by the aerosol‐induced radiative cooling. In contrast, the warming (positive aerosol effects on LWCF) in South East Asia is due mainly to the aerosol effect on homogeneous freezing, thus, reducing the ice particle size and prolonging the existence of ice cloud. Our results emphasize that a comprehensive analysis of integrated aerosol effects on both warm and ice clouds is necessary for better understanding the aerosol effects on LWCF.
Normative data and correlation between dynamic knee valgus and neuromuscular response among healthy active males: a cross-sectional study
Authors: Llurda-Almuzara Luis , Pérez-Bellmunt Albert , López-de-Celis Carlos , Aiguadé Ramón , Seijas Roberto , Casasayas-Cos Oriol , Labata-Lezaun Noe , Alvarez Pedro 
Published: December 2020

AbstractThe dynamic knee valgus (DKV) during different sport maneuvers has been widely described as risk factor to develop an anterior cruciate ligament injury. Hip and knee muscles seem to have a crucial role to prevent the dynamic knee valgus. This study aimed to give normative and correlational data about DKV and hip and knee neuromuscular response (NMR) among healthy active males. The hypothesis is that DKV could be correlated with hip NMR. A cross-sectional correlational study. Research Anatomy Laboratory. The study was carried out among 50 active, non-injured males. Dynamic Knee-Valgus angle and lower limb posterior chain muscles Neuromuscular Response. DKV was measured using Kinovea software during a Single-Legged Drop Jump test and NMR was measured using tensiomyography and myotonometry for gluteus maximum, biceps femoris, semitendinosus, lateral and medial gastrocnemius. Right and left limbs were both performed and analyzed independently. No significant correlation was observed between DKV and hip and knee muscles NMR. This study shows normative and correlational data about dynamic knee valgus, tensiomyography and myotonometry for healthy and active males. The DKV control seems to be non-correlated with isolated hip and knee muscles NMR so this suggests it is more about Central Nervous System activity than about isolated muscles NMR.
Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus
Authors: Sanabria Viviam , Bittencourt Simone , Perosa Sandra R. , de la Rosa Tomás , da Graça Naffah-Mazzacoratti Maria , Andersen Monica L. , Tufik Sergio , Cavalheiro Esper A. , Amado Débora 
Published: December 2020

AbstractThe Amazon rodent Proechimys guyannensis is widely studied for hosting various pathogens, though rarely getting sick. Previous studies on male Proechimys have revealed an endogenous resistance to epilepsy. Here, we assess in female Proechimys, whether sex hormones and biochemical aspects can interfere with the induction of status epilepticus (SE). The lithium-pilocarpine ramp-up protocol was used to induce SE, and blood sera were collected at 30 and 90 min after SE, alongside brains, for biochemical, western blot and immunohistochemical analyses. Results from non-ovariectomised (NOVX) Proechimys were compared to ovariectomised (OVX) animals. Data from female Wistars were used as a positive control of SE inductions. SE latency was similar in NOVX, OVX, and female Wistars groups. However, the pilocarpine dose required to induce SE in Proechimys was higher (25- to 50-folds more). Despite a higher dose, Proechimys did not show strong SE like Wistars; they only reached stage 2 of the Racine scale. These data suggest that female Proechimys are resistant to SE induction. Glucose and progesterone levels increased at 30 min and returned to normal at 90 min after SE. A relevant fact because in humans and rodents, SE leads to hypoglycaemia after 30 min of SE and does not return to normal levels in a short time, a typical adverse effect of SE. In OVX animals, a decrease in GABAergic receptors within 90 min of SE may suggest that ovariectomy produces changes in the hippocampus, including a certain vulnerability to seizures. We speculate that progesterone and glucose increases form part of the compensatory mechanisms that provide resistance in Proechimys against SE induction.
A proof of concept ‘phase zero’ study of neurodevelopment using brain organoid models with Vis/near-infrared spectroscopy and electrophysiology
Authors: Dutta Anirban , Karanth Sneha Sudhakar , Bhattacharya Mahasweta , Liput Michal , Augustyniak Justyna , Cheung Mancheung , Stachowiak Ewa K. , Stachowiak Michal K. 
Published: December 2020

AbstractHomeostatic control of neuronal excitability by modulation of synaptic inhibition (I) and excitation (E) of the principal neurons is important during brain maturation. The fundamental features of in-utero brain development, including local synaptic E–I ratio and bioenergetics, can be modeled by cerebral organoids (CO) that have exhibited highly regular nested oscillatory network events. Therefore, we evaluated a 'Phase Zero' clinical study platform combining broadband Vis/near-infrared(NIR) spectroscopy and electrophysiology with studying E–I ratio based on the spectral exponent of local field potentials and bioenergetics based on the activity of mitochondrial Cytochrome-C Oxidase (CCO). We found a significant effect of the age of the healthy controls iPSC CO from 23 days to 3 months on the CCO activity (chi-square (2, N = 10) = 20, p = 4.5400e−05), and spectral exponent between 30–50 Hz (chi-square (2, N = 16) = 13.88, p = 0.001). Also, a significant effect of drugs, choline (CHO), idebenone (IDB), R-alpha-lipoic acid plus acetyl-l-carnitine (LCLA), was found on the CCO activity (chi-square (3, N = 10) = 25.44, p = 1.2492e−05), spectral exponent between 1 and 20 Hz (chi-square (3, N = 16) = 43.5, p = 1.9273e−09) and 30–50 Hz (chi-square (3, N = 16) = 23.47, p = 3.2148e−05) in 34 days old CO from schizophrenia (SCZ) patients iPSC. We present the feasibility of a multimodal approach, combining electrophysiology and broadband Vis–NIR spectroscopy, to monitor neurodevelopment in brain organoid models that can complement traditional drug design approaches to test clinically meaningful hypotheses.