bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk
Authors: Matthews Charles E. , Moore Steven C. , Arem Hannah , Cook Michael B. , Trabert Britton , Håkansson Niclas , Larsson Susanna C. , Wolk Alicja , Gapstur Susan M. , Lynch Brigid M. , Milne Roger L. , Freedman Neal D. , Huang Wen-Yi , Berrington de Gonzalez Amy , Kitahara Cari M. , Linet Martha S. , Shiroma Eric J. , Sandin Sven , Patel Alpa V. , Lee I-Min 
Published: December 2019

PURPOSETo determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.METHODSData from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend ( P < .05) and 95% CIs (< 1.0).RESULTSA total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.CONCLUSIONHealth care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers.
Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome—A Case-Control Study
Authors: Tirosh Amit , RaviPrakash Harish , Papadakis Georgios Z , Tatsi Christina , Belyavskaya Elena , Charalampos Lyssikatos , Lodish Maya B , Bagci Ulas , Stratakis Constantine A 
Published: December 2019

Abstract

Background
Young patients with Cushing Syndrome (CS) may develop cognitive and behavioral alterations during disease course.

Methods
To investigate the effects of CS on the brain, we analyzed consecutive MRI scans of patients with (n = 29) versus without CS (n = 8). Multiple brain compartments were processed for total and gray/white matter (GM/WM) volumes and intensities, and cortical volume, thickness, and surface area. Dynamics (last/baseline scans ratio per parameter) were analyzed versus cortisol levels and CS status (persistent, resolved, and non-CS).

Results
Twenty-four-hour urinary free cortisol (24hUFC) measurements had inverse correlation with the intensity of subcortical GM structures and of the corpus callosum, and with the cerebral WM intensity. 24hUFC dynamics had negative correlation with volume dynamics of multiple cerebral and cerebellar structures. Patients with persistent CS had less of an increase in cortical thickness and WM intensity, and less of a decrease in WM volume compared with patients with resolution of CS. Patients with resolution of their CS had less of an increase in subcortical GM and cerebral WM volumes, but a greater increase in cortical thickness of frontal lobe versus controls.

Conclusion
Changes in WM/GM consistency, intensity, and homogeneity in patients with CS may correlate with CS clinical consequences better than volume dynamics alone.
Potential Impact of BMI on the Aggressiveness of Presentation and Clinical Outcome of Differentiated Thyroid Cancer
Authors: Matrone Antonio , Ceccarini Giovanni , Beghini Marianna , Ferrari Federica , Gambale Carla , D’Aqui Mariaida , Piaggi Paolo , Torregrossa Liborio , Molinaro Eleonora , Basolo Fulvio , Vitti Paolo , Santini Ferruccio , Elisei Rossella 
Published: December 2019

Abstract

Background
Obesity is a risk factor for several cancers, including differentiated thyroid cancer (DTC). Moreover, it has also been investigated as a potential risk factor for aggressiveness of DTC, but the data gathered so far are conflicting. The aim of our study was to evaluate the relationship between body mass index (BMI), aggressiveness of DTC at diagnosis, and clinical outcome.

Methods
We evaluated 1058 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of first radioactive iodine (131I) treatment. Patients were divided into 4 groups based on their BMI: underweight (&lt; 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (≥ 30 kg/m2). Histological aggressiveness of DTC at the time of diagnosis and clinical outcome according to 2015 American Thyroid Association (ATA) guidelines were evaluated.

Results
No differences in histological features, ATA risk of recurrence, activity of 131I administered and prevalence of 131I avid metastatic disease after first131I treatment, have been demonstrated among the groups. Furthermore, at the end of follow up (median = 5.7 years), no differences were evident in the number of further treatments performed as well as in the clinical response.

Conclusions
In our study group of Caucasian subjects, we could not demonstrate any association between BMI and aggressiveness of DTC, neither at the time of diagnosis nor during follow-up. These data indicate that postsurgical assessment and therapeutic attitude for treatment and follow-up of DTC should be based on the class of risk applied to the general population, with no concern for BMI.
Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells
Authors: Aghazadeh Yasaman , Venugopal Sathvika , Martinez-Arguelles Daniel Benjamin , Boisvert Annie , Blonder Josip , Papadopoulos Vassilios 
Published: December 2019

Abstract
Testosterone production occurs in the Leydig cells of the testes and is essential for virilization, development, reproduction, and quality of life. Although the steroidogenic proteins involved in cholesterol conversion to testosterone (T) are well characterized, the causes of reduced T during fetal, neonatal, and adult life remain uncertain. It is well established that normal cellular function is achieved through fine-tuning of multiple rather than single protein networks. Our objective was to use mass spectrometry (MS)-based proteomics to identify which cellular pathways, other than the steroidogenic machinery, influence testosterone production in MA-10 mouse tumor Leydig cells. The 14-3-3 family of scaffolds mediate protein–protein interactions facilitating the crosstalk between protein networks. We previously showed that in MA-10 cells, 14-3-3γ is a critical regulator of steroidogenesis. Therefore, identifying proteins that interact with 14-3-3γ during steroidogenesis could provide clues into the other networks involved. Using liquid chromatography (LC)–MS, we identified 688 proteins that interact with 14-3-3γ and thus potentially impact MA-10 cell steroidogenesis. The identified proteins belong to multiple protein networks, including endoplasmic reticulum–Golgi cargo sorting and vesicle biogenesis, micro ribonucleic acid-induced gene silencing, inflammation, and vesicle trafficking, to name a few. We found that silencing one of the candidates, Sec23ip, a protein known to be involved in vesicle trafficking, resulted in decreased steroidogenesis. We further showed that in Sec23ip-silenced MA-10 cells, cholesterol mobilization from the cytoplasmic membrane to mitochondria is impaired. Taken together these data suggest that Sec23ip is involved in cholesterol trafficking to supply cholesterol for acute steroidogenesis through its interactions with 14-3-3γ.
Impact of High-Intensity Interval Training, Moderate-Intensity Continuous Training, and Resistance Training on Endothelial Function in Older Adults
Authors: O’BRIEN MYLES W. , JOHNS JARRETT A. , ROBINSON SUSAN A. , BUNGAY AMANDA , MEKARY SAID , KIMMERLY DEREK S. 
Published: December 2019

ABSTRACT

Purpose
It is unclear if high-intensity interval training (HIIT) elicits superior improvements in brachial artery (BA) flow-mediated dilation (FMD) responses (i.e., endothelial-dependent vasodilation) than moderate-intensity continuous training (MICT) or resistance training (RT) in otherwise healthy older adults. Whether HIIT enhances lower-limb FMD responses and/or augments low flow-mediated constriction (L-FMC) (endothelial-dependent vasoconstriction) responses more than MICT or RT is also unknown. We tested the hypothesis that HIIT would improve BA and popliteal artery (POP) FMD and L-FMC responses more than MICT or RT in healthy older adults.

Methods
Thirty-eight older adults (age, 67 ± 6 yr) performed 6 wk of either HIIT (2 × 20 min bouts alternating between 15-s intervals at 100% of peak power output [PPO] and passive recovery [0% PPO]; n = 12), MICT (34 min at 60% PPO; n = 12), or whole-body RT (8 exercises, 2 × 10 repetitions; n = 14). The L-FMC and FMD were measured before and after training using high-resolution ultrasound and quantified as the percent change in baseline diameter during distal cuff occlusion and after cuff release, respectively.

Results
Resting BA blood flow and vascular conductance (both, P < 0.003) were greater after HIIT only. The HIIT and MICT similarly increased BA-FMD (pre–post: both, P < 0.001), but only HIIT improved BA L-FMC (P < 0.001). Both HIIT and MICT similarly enhanced POP FMD and L-FMC responses (both, P < 0.045). Resistance training did not impact FMD or L-FMC responses in either artery (all, P > 0.20).

Conclusions
HIIT and MICT, but not RT, similarly improved lower-limb vasodilator and vasoconstrictor endothelial function in older adults. Although HIIT and MICT groups enhanced BA vasodilator function, only HIIT improved resting conductance and endothelial sensitivity to low-flow in the BA. In the short-term, HIIT may be most effective at improving peripheral vascular endothelial function in older adults.
TASAWUF PENDIDIKAN: DARI SPIRITUALITAS MANUSIA MENUJU INSAN KAMIL
Authors: Hanani Ahmad , Hamidi Nur 
Published: December 2019

This article examines the relation and position of human beings in the context of "educational mysticism". This study is important to do using the literature approach to descriptive conceptual research to see the position of man as a creature of God specifically created by God and for certain purposes. Humans according to mysticism are creatures of God that are specially created ("copy") by God and for the purpose of His tajalli (tanazul) and because humans have the potential of the lut because of certain temptations he can glide to a low level, if he wants to return to his fitrah, then he should make a certain effort (mujahadah and riyadlah) in order to climb (taraqi) again "unite" with Him throughthe fourstages of tajalli. That tajalli, both in the process of tanazul and taraqqi, should be understood figuratively and metaphorically (majazi). This situation is due to the existence of love and longing for Allah SWT, so that what is seen and felt is He alone, like someone who is hit by romance with his lover, who is loved and loved, always imagined in his eyes and heart. Thus, a compromise can be made between the concept of Sufism al-Shafi, namely Sufism which combines Sufic vision with a vision of philosophy and Sunni Sufism, namely Sufism which assumes itself to the Koran and Al-Hadist.
Keywords: Mysticism, Education, Sprituality, Insan Kamil, Tanazul dan Taraqqi.
Abstrak
Artikel ini mengkaji relasi dan kedudukan manusia dalam konteks “tasawuf pendidikan”. Kajian ini penting dilakukan dengan menggunakan pendekatan literature research-konseptual deskriptif untuk melihat kedudukan manusia sebagai makhluk Tuhan yang dicipta secara khusus oleh Tuhan dan untuk tujuan tertentu. Manusia menurut tasawuf adalah makhluk Tuhan yang dicipta secara khusus (“copi”) oleh Tuhan dan untuk tujuan tajalli-Nya (tanazul) dan karena manusia mempunyai potensi lahut yang karena berbagai godaan tertentu dia bisa meluncur ke tingkat yang rendah, apabila dia ingin kembali ke fitrahnya, maka hendaknya melakukan upaya tertentu (mujahadah dan riyadlah) agar bisa mendaki (taraqi) kembali “bersatu” dengan-Nya melalui empat tahap tajalli. Bahwa tajalli, baik dalam proses tanazul dan taraqqi itu, hendaknya dipahami secara figuratif dan metoforis(majazi). Dengan demikian, maka bisa dilakukan kompromis antara konsep tasawuf al-shafi, yaitu tasawuf yang memadukan antara visi sufistik dengan visi filsafat dan tasawuf sunni, yaitu tasawuf yang mengasaskan diri kepada Al-Quran dan Al-Hadist.
Kata kunci: Tasawuf, Pendidikan, Spritualitas, Insan Kamil, Tanazul dan Taraqqi.
PENGEMBANGAN KURIKULUM PROGRAM UNGGULAN DI SD MUHAMMADIYAH KLECO KOTAGEDE
Authors: Aji Gesang Setyo 
Published: December 2019

The crisis in the dimension of the quality of human resources and the crisis in the field of the identity and morality of Indonesian people is a troubling education problem in Indonesia. This paper seeks to convey views about managerial efforts in curriculum development for leading programs in the context of Muhammadiyah Elementary schools. This study uses a qualitative field research approach at SD Muhammadiyah Kleco. The results of the study show: The implementation of the management of Leading Program Development at the Muhammadiyah Elementary School in Kleco, Kotagede, Yogyakarta is not much different from the management of PAI curriculum in other schools which includes planning, organizing, implementing, and evaluating curriculum activities. The results achieved from the implementation of the Featured Program at SD Muhammadiyah Kleco Kotagede are the increasing knowledge and abilities of students, especially in the aspects of the Qur'an. In addition, the implementation of the Featured Program also had a positive impact on student achievement in the religious field and besides that it was also a branding force for the Muhammadiyah Kleco Elementary School in Yogyakarta to compete in the education market especially in the city of Yogyakarta.
Abstrak
Krisis dalam dimensi kualitas sumber daya manusia maupun krisis dalam bidang identitas dan moralitas manusia Indonesia merupakan problematika pendidikan yang meresahkan di Indonesia. Tulisan ini berupaya untuk menyampaikan pandangan tentang upaya manajerial pengembangan kurikulum untuk program-program unggulan dalam konteks sekolah Dasar Muhammadiyah. Penelitian ini menggunakan pendekatan kualitatif field research di SD Muhammadiyah Kleco. Hasil penelitian menunjukkan: Implementasi manajemen Pengembangan Program Unggulan di SD Muhammadiyah Kleco Kotagede Yogyakarta tidak jauh berbeda dengan manajemen kurikulum PAI di sekolah lain yang meliputi kegiatan perencanaan, penggorganisasian, pelaksanaan, dan evaluasi kurikulum. Hasil yang dicapai dari pelaksanaan Program Unggulan di SD Muhammadiyah Kleco Kotagede adalah semakin bertambahnya pengetahuan dan kemampuan siswa terutama pada aspek Al Qur’an. Selain itu, pelaksanaan Program Unggulan juga memberikan dampak positif kepada prestasi siswa di bidang keagamaan dan selain itu juga sebagai daya jual (branding) SD Muhammadiyah Kleco Kotagede Yogyakarta untuk bersaing dalam pasar pendidikan khususnya di kota Yogyakarta.
A simple room temperature-static bioreactor for effective synthesis of hexyl acetate
Authors: Cao Wenwen , Cong Fangdi , Kang Jie , Zhang Shulin , Li Xin , Wang Xinxin , Li Ping , Yu Jinze 
Published: December 2019

AbstractFor green synthesis in organic phases, the catalysis of lipases needs to be further improved. Here a strategy is to simulate the activation of lipases at water/oil interface by immobilizing lipase on an available carrier material, which can replace the water at the interface to stabilize enzyme against denaturation from organic phase. The carrier is selected as cotton fiber on whichPseudomonas cepacialipase is immobilized by physical adsorption in a column glass bottle to form a simple bioreactor together with the bottle. In synthesis of fragrance ester hexyl acetate via transesterification of hexanol with vinyl acetate, the bioreactor exhibits a 3-fold increase in the ability to transform substrate, relative to native lipase in terms of the initial period of reaction at 37°C and 160 rpm. And also the bioreactor is very stable in catalysis for that it has an extra long half lifet1/2= 636 h, calculated from the decrease degree of molar conversions in six times of 6-hour transesterifications. More interestingly, the bioreactor behaves excellent activity at room temperature and in a static state, and can transform nearly 100% hexanol after 48 h. All these indicate that the bioreactor has great potential for industrial application.
CGF treatment of leg ulcers: A randomized controlled trial
Authors: Amato Bruno , Farina Michele Angelo , Campisi Silvana , Ciliberti Marino , Donna Vincenzo Di , Florio Anna , Grasso Antonino , Miranda Rosario , Pompeo Francesco , Farina Eleonora , Serra Raffaele , Cirocchi Roberto , Calemma Francesca , Rocca Aldo , Compagna Rita 
Published: December 2019

Abstract

Background
Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.

Aim
The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.

Methods
Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.

Results
The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.

Conclusions
These results support the CGF’s clinical use for improving clinical outcomes in mixed ulcers of the legs.
Design of inorganic coils for high temperature electrical machines
Authors: Elmadah Hamed , Roger Daniel , Takorabet Noureddine 
Published: December 2019

Abstract
The paper deals with a high frequency model of inorganic coils used to build high temperature (HT∘) motor. The HT∘ wire has a nickel layer that protects the copper against oxidation and a thin inorganic coating, which has poor electrical and mechanical properties. Therefore, the coils must be designed with a special care for getting a good distribution of turn-to-turn voltage during the fast transients excited by the steep fronted voltages of the PWM inverter.A specific coil structure is proposed and a high frequency (HF) equivalent circuit able to compute the turn-to-turn voltages during transients. The voltage distribution between the coils of a stator phase is also detailed.
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum
Authors: Morrison Vivianne E. , Smith Victoria N. , Huang Jeffrey K. 
Published: December 2019

AbstractMyelination of the CNS relies on the production and differentiation of oligodendrocyte (OL) precursor cells (OPCs) into mature OLs. During the first month of postnatal life, OPCs that populate the corpus callosum (CC) arise from neural stem cells (NSCs) in the subcallosal subventricular zone (SVZ), and then differentiate to generate myelinating OLs. However, the signals that regulate these processes are not fully understood. In this study, we show that endogenous expression of the retinoic acid (RA)-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2) is required for OPC generation and differentiation in the postnatal subcortical white matter. In male and female pups, conditional deletion ofRaldh2reduced OPC numbers and differentiation. Moreover, decreased OPC numbers coincided with reductions in NSC survival and expression of the sonic hedgehog (SHH) signaling effector proteinGli1in the SVZ. Additionally, GFAP expression in the CC was decreased, and cortical neuron numbers were altered. Our work suggests a role for endogenous RALDH2-dependent RA synthesis in OPC production and differentiation in the CC, as well as in the development of other cell types derived from NSCs in the embryonic ventricular zone (VZ) and SVZ, as well as the postnatal subcallosal SVZ.
In the Footsteps of Julia Pastrana. Cultural Responses to an Ape-woman's Stay in Warsaw in 1858 and Reaction of Polish Press to Her Extraordinary Body1
Authors: Kopania Izabela 
Published: December 2019

Abstract
Julia Pastrana is one of the best known personalities of the mid-19th-century freak show business, understood as institutionalized exhibitions of human oddities. Born in 1834 in Mexico, she suffered from a genetic disorder which resulted in abnormal hair growth. Her career as a profit-making exhibit began in 1854 and lasted till 1860. Together with her impresario and husband Theodore Lent she toured the US, Canada and the British Isles from where she moved to Berlin, Vienna and Warsaw. Pastrana further headed for St. Petersburg and Moscow where she died in childbirth. While her odyssey in the US and Britain is well known, her stay in Central and Eastern Europe and Russia remains shrouded in obscurity. The aim of this article is to fill this gap in Pastrana's biography. Reconstructing her itinerary in Eastern Europe, I will focus especially on her visit to Warsaw. Drawing mainly on press accounts and unpublished iconographic sources, I will analyze both Pastrana's ‘enfreakment’ and commodification. My point is to see how her embodiment of difference was conceptualized at the eastern borders of Europe and how local artists and entrepreneurs reacted to her performances and the possibilities for making money that the freak show business offered.
Consuming Masculinity and Race. Circus Bodies in Strength Shows and Wrestling Fights
Authors: Czarnecka Dominika 
Published: December 2019

Abstract
This article describes the mass consumption of masculinity and race within the entertainment landscape in Poland in the years 1850–1939. Focusing on the ever-increasing popularity of strength shows and wrestling fights held in circuses and performed in front of urban audiences, the article intends to demonstrate the strategies of presenting white and black athletes in circus arenas, and to examine the meanings and roles of strength shows and wrestling fights in the collective imagination on racial and gender differences.