bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias
Authors: Andreieva S.V. , Kyselova O.A. , Serbin I.M. , Alkhimova O.G. 
Published: June 2020

Summary. Aim: To determine ways of formation of abnormal karyotypes in two clinical cases of secondary acute leukemias of myeloid and lymphoid lineages. Material and Methods: Bone marrow cells of one patient with therapy-related acute monoblastic/monocytic leukemia and one patient with therapy-related acute lymphoblastic leukemia were examined by cytogenetic GTG banding technique. Results: An unusually large number of quantitative and structural anomalies of chromosomes in therapy-related acute monoblastic/monocytic leukemia have been established, which have many features in common with chromothripsis, namely instability of clones that manifested itself through quantitative anomalies (trisomy, monosomy, marker chromosomes, including chromosome 5), structural — t(9;11), deletions of the long arm of chromosomes 8 and 14, derivatives of chromosomes 3 and 7, ring chromosomes. In case of secondary acute lymphoblastic leukemia, the anomalous clone with balanced translocation in all 20 metaphase plates 46,XX,t(1;15)(p21;q24) has been registered, which is not described in the literature. Therefore, the diagnostic and prognostic value of such anomaly is unknown. Conclusions: Rearrangement with the involvement of the locus 11q23 was recorded in the case of chemotherapy treatment without topoisomerase II inhibitors. The complex karyotype formed after chemotherapy and radiotherapy, which is a criterion for an unfavorable prognosis of the disease, is considered as the equivalent of chromothripsis. t(1;15) is considered as an abnormality that can be attributed to the group of favorable secondary acute lymphoblastic leukemia prognosis.
Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
Authors: Onyshchenko K.V. , Voitsitskyi T.V. , Grygorenko V.M. , Saidakova N.O. , Pereta L.V. , Onyschuk A.P. , Skrypkina I.Ya. 
Published: June 2020

Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
Authors: Lamdan H. , Garcia-Lazaro R.S. , Lorenzo N. , Caligiuri L.G. , Alonso D.F. , Farina H.G. 
Published: June 2020

Summary. Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro.
Risk of Psychological Distress, Pervasiveness of Stigma and Utilisation of Support Services: Exploring Paramedic Perceptions
Authors: Mackinnon Kelly , Everett Timothy , Holmes Lisa , Smith Erin , Mills Brennen 
Published: June 2020

Introduction Paramedics are exposed to significant and cumulative stressors that contribute to poor mental health. The provision of effective and engaging mental health support is essential in improving overall wellbeing. Many ambulance services have adapted their available support services to reflect this need. However, there remains limited research into the perceived efficacy of these services and barriers that limit uptake from paramedics. Methods Paramedics and ambulance volunteers from Australia and New Zealand were invited to complete an online survey consisting of a series of Likert-scale and open-ended response questions. The well-validated Kessler Psychological Distress Scale was also incorporated into the online survey. Results A total of 184 participants completed the survey. A total of 50 (27%) participants reported high/very high levels of psychological distress. Participants exposed to at least one adverse event while working reported higher psychological distress scores than those that had not. Just over half (51%) of all participants disagreed/strongly disagreed there was no stigma associated with seeking mental health support from paramedic colleagues and 54% of participants disagreed/strongly disagreed there was no stigma from managerial staff. Conclusion These findings suggest paramedics are at a greater risk of psychological distress than the general population. This is particularly problematic given there is a clear perception of ongoing stigma among paramedics associated with the utilisation of mental health support services. Future research should explore methods for reducing stigma and encouraging help-seeking behaviours in this vulnerable population throughout all phases of an emergency service workers career.
Editorial
Authors: Marques Gleidson Vieira 
Published: June 2020

A revista Paubrasilia é uma publicação eletrônica oficial do Jardim Botânico FLORAS e alcança o seu primeiro biênio. Durante este período a Paubrasilia coletivizou esforços e contribuiu com o compartilhamento de conhecimentos em botânica e a diversidade vegetal no Brasil.
Pengembangan Industri Kreatif dari Iluminasi Naskah Kuno Pariangan: Studi Motif Batik Pariagan, Sumatra Barat
Authors: Basa Irwan Malin 
Published: June 2020

Abstract: This article discussess about the creative industry development from the illumination of manuscripts in Pariangan. This research was conducted in Pariangan for six months. A case study approach was applied in this research with some consideration. First, Pariangan is called as one of the most beautiful villages in the world since 2012. It was anounced by the most popular travel magazine in America named American Budget Travelers. Second, it has many traditional manuscripts written in Arabic, Malay and Minang language. The manuscripts were saved in surau, in traditional houses and also as a personal collection. Most of the the manuscripts have different beautiful illumination. Third, to empower local people to revitalize their “lost” tradition to make the design of batik. The result of this research shown that there were twenty five of the batik designs which performs local wisdom of Pariangan. Until now there were 13 of the designs have been registered to the ministry of Law and Human Right of the Republic of Indonesia. The last one is local people of Pariangan are able to make batik again.
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Abstrak: Tulisan ini membahas masalah pengembangan industri kreatif dari iluminasi naskah kuno yang ada di Pariangan, Tanah Datar, Sumatera Barat. Penelitian ini menggunakan metode case study research dan dilaksanakan selama enam bulan. Ada beberapa alasan untuk melaksanakan penelitian ini di Pariangan. Pertama, Pariangan adalah desa terindah di dunia menurut majalah pariwisata terkenal dari Amerika yaitu American Budget Travelers. Kedua, Pariangan memiliki banyak naskah kuno yang memiliki ragam hias atau iluminasi yang indah dan naskah naskah tersebut masih tersimpan di surau, rumah gadang dan koleksi pribadi masyarakat. Ketiga, untuk memberdayakan penduduk lokal tentang tradisi mereka yang pernah hilang yaitu mencelup kain. Sebagai hasilnya, sudah tiga belas design batik yang didaftarkan sebagai Hak Cipta dan Hak Kekayaan Intelektual ke Kementerian Hukum dan Hak Azazi Manusia Republik Indonesia. Dan yang terakhir adalah masyarakat Pariangan bisa melestarikan tradisi mereka dengan membuat batik kembali yang dulu pernah hilang.
Penyakit Lelaki: Kajian Berdasarkan Kitab-Kitab Tib Melayu Terpilih
Authors: Karim Abdul Razak Abdul 
Published: June 2020

Abstract: One of the most well-known diseases in any of the scriptures is that of men. It can be said that there is no book on this issue that does not address the problem of this type of disease as most traditional practitioners are male. Therefore, men's disease is a priority and an important part of most Kitab Tib. In this paper we will discuss various men's diseases that are found in most tib books as well as the treatment methods and prohibitions that a patient should follow. In this study several books of tib are used, including the Tibetan Collection of the University of Malaya with MSS254 and MSS172, the National Library of Malaysia collection number MSS2219. Two books from Pontianak and also from Odor, Buton are also used in this research data. The selection of these manuscripts is a comparison to look at the similarities and differences between traditional medicine practitioners in dealing with men's disease. An analysis of the names of the diseases, the methods of treatment used and also the taboos found in these books of tib will be described in this paper.
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Abstrak: Salah satu daripada keuzuran atau penyakit yang popular dan banyak terdapat dalam mana-mana kitab tib ialah penyakit golongan lelaki. Boleh dikatakan tidak ada kitab tib yang tidak menyentuh masalah penyakit golongan ini memandangkan kebanyakan pengamal perubatan tradisional merupakan golongan lelaki. Oleh yang demikian, penyakit golongan lelaki menjadi keutamaan dan perkara penting dalam kebanyakan kitab-kitab tib.Dalam makalah ini akan dibincangkan pelbagai penyakit golongan lelaki yang terdapat dalam kebanyakan kitab tib dan juga kaedah rawatan serta pantang larang yang perlu dipatuhi oleh seseorang pesakit itu. Dalam kajian yang dilakukan beberapa buah kitab tib digunakan, antaranya Kitab Tib Koleksi Universiti Malaya dengan nombor MSS254 dan MSS172, kitab tib koleksi Perpustakaan Negara Malaysia dengan nombor MSS2219. Dua buah kitab tib dari Pontianak dan juga dari Bau-bau, Buton juga digunakan dalam data kajian ini. Pemilihan naskah-naskah ini adalah sebagai perbandingan untuk melihat persamaan dan juga perbezaan pengamal perubatan tradisional dalam menangani masalah penyakit golongan lelaki. Analisis dari segi nama-nama penyakit, kaedah rawatan yang digunakan dan juga pantang larang yang terdapat dalam kitab-kitab tib ini akan dihuraikan dalam makalah ini.
Naskah Persuratan Melayu: Pemeliharaan dan Digitalisasi di Malaysia
Authors: Asyikin Nur , Normalina Normalina 
Published: June 2020

Abstract: Malay manuscripts have been widely concerned through research and studies by Malaysian scholars, as well as most of the world's scholars. Finding shows that, the heritage of Malay literary contains variety of valuable knowledge and symbolizing the nation’s civilization that must be preserved for the benefit of the future generation. The Malay literary heritage documentation is important in displaying the diversity, style and genre of Malay writings and able to streamline the history of Malay knowledge, especially in Malay literature. This led to encourage efforts in ensuring this valuable copies remain conserve through preservation and digitalization activities so it’s not drowning in time and circumstances, also only remain of history that is undescribed, and face various factors that can cause to damage. Researcher focused on the efforts and methods of preservation and digitization of Malay manuscripts especially in Malaysia. In addition, discussing the challenges and problems faced. This study will proposes some measures as a guide of the institutions, collectors and owners of the manuscripts that lead to the discovery of new knowledge.
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Abstrak: Naskhah persuratan Melayu telah mendapat perhatian dari segi kajian oleh para sarjana Malaysia, mahupun sebahagian besar sarjana dunia. Hasil penelitian menunjukkan warisan khazanah persuratan Melayu, menyimpan pelbagai ilmu yang tidak ternilai harganya dan merupakan lambang tamadun dan peradaban bangsa yang perlu dipulihara untuk dimanfaatkan oleh generasi alaf baru. Warisan dokumentasi persuratan Melayu penting dalam menampilkan kekayaan ragam dan genre penulisan orang Melayu serta merangkaikan sejarah ilmu orang Melayu khususnya dalam persuratan Melayu. Hal ini mendorong usaha memastikan naskhah bernilai ini kekal terjaga melalui aktiviti pemuliharaan dan pendigitalan agar tidak tenggelam ditelan zaman dan keadaan, dan hanya kekal dalam lipatan sejarah yang tidak dihuraikan serta berdepan dengan pelbagai faktor yang boleh menyebabkan kerosakan. Pengkaji memberi tumpuan tentang usaha serta kaedah pemuliharaan dan pendigitalan naskhah persuratan Melayu khususnya di Malaysia. Di samping itu, membincangkan juga tentang cabaran dan permasalahan yang dihadapi dalam menyelamatkan naskhah khazanah ini. Kajian dan penelitian ini mengemukakan cadangan untuk dijadikan panduan kepada institusi penyimpan dan pemilik naskhah yang membawa kepada penemuan ilmu baru.
IMAGENS, ADAPTAÇÕES E INCLUSÃO
Authors: Machado Ledo Vaccaro , Segadas-Vianna Claudia 
Published: June 2020

A assunção de uma sociedade inclusiva impõe que se viabilize a participação de pessoas com deficiência visual em avaliações públicas, e uma das formas dessa viabilidade é a assistência de um Ledor, um profissional que lê essas avaliações públicas. O desenvolvimento de tecnologias ligadas à produção e impressão das provas das avaliações públicas reconfigurou o perfil dessas provas, dandolhes grande apelo visual através do uso de imagens e aumentando a complexidade das ações do Ledor. Na esteira dessa complexidade surge a prova de Ledor, uma versão adaptada da prova convencional na qual as imagens são descritas. Analisamos as adaptações para Ledor das provas de Matemática do ENEM e do nível 3 da OBMEP dos anos de 2016, 2017 e 2018, objetivando averiguar a equivalênciaentre a prova convencional e a versão do Ledor. Nesse artigo, destacamos as observações referentes à análise das adaptações de imagens. A complexidade e os limites dessas adaptações levam-nos a questionar se as adaptações são consonantes com os princípios de construção de uma sociedade inclusiva.
PENSAMENTO GEOMÉTRICO: EM BUSCA DE UMA CARACTERIZAÇÃO À LUZ DE FISCHBEIN, DUVAL E PAIS
Authors: Costa André Pereira da 
Published: June 2020

Este artigo, de natureza teórica, tem por objetivo construir uma caracterização de pensamento geométrico. Em nosso entendimento, esse texto é importante visto que não há uma unanimidade entre os estudiosos acerca de como se constitui essa forma de pensar em Matemática. Nessa direção, decidimos elaborar uma caracterização dessa instância de pensamento tendo por base as discussões teóricas de Efraim Fischbein, Raymond Duval e Luiz Carlos Pais, três autores que realizaram pesquisas relevantes sobre o assunto. Assim, concluímos que o pensamento geométrico é a capacidade mental de construir conhecimentos geométricos, de aplicar de modo coerente os instrumentos geométricos na resolução de problemas. É a capacidade de compreender a natureza dos fenômenos e inferir sobre eles, de identificar e perceber a importância da Geometria como uma ferramenta para entendimento do mundo físico e como um modelo matemático para compreensão do mundo teórico.
DESAFIOS NO ENSINO DA MATEMÁTICA NA EDUCAÇÃO BÁSICA CATARINENSE ENTRE AS DÉCADAS DE 1970 E 1990
Authors: Maier Lidiane Tania Ronsoni , Richit Adriana 
Published: June 2020

O ensino da Matemática em escolas públicas de santa Catarina, especialmente na região Oeste, foi historicamente marcado por desafios e limites de natureza diversa, sobretudo nas escolas situadas em zonas afastadas dos centros urbanos. Além disso, o desenvolvimento da educação superior na referida região também foi lento, aspecto esse que limitava as possibilidades de formação à docência daqueles que aspiravam ingressar na profissão. Face a isto, interessamo-nos em investigar os desafios enfrentados por professoras de matemática da educação básica da 4.ª Gerência de Educação de Santa Catarina, entre as décadas de 1970 a 1990, como forma de produzir uma perspectiva histórica sobre o ensino da matemática na referida região, evidenciando aspectos de natureza distinta que marcaram este processo no período citado. Para tanto, realizamos entrevistas com cinco professoras que atuavam em escolas da rede pública estadual à época, guiando-nos pelos pressupostos teóricometodológicosda História Oral. As entrevistas foram gravadas, transcritas e textualizadas,constituindo o documento-base do estudo. Como resultados evidenciamos desafios de três naturezas: desafios na formação, profissão e ensino de matemática. Por fim, o estudo pode constituir-se em fontehistórica, que embasa uma versão da história do ensino em Santa Catarina, fundamentada na narrativa das vivências das professoras.
ANÁLISE DAS DEMANDAS COGNITIVAS NAS TAREFAS DE PROBABILIDADE PROPOSTAS EM LIVROS DIDÁTICOS DOS PRIMEIROS ANOS DE ESCOLARIZAÇÃO
Authors: Santana Michaelle R. M. de , Fernandes José  António , Borba Rute Elizabete de S. R. 
Published: June 2020

Dos vários materiais didáticos que configuram as práticas educativas, os materiais curriculares, em particular os livros didáticos, desempenham um papel preponderante nos processos de ensino e aprendizagem. O objetivo geral deste estudo é compreender como é explorado o conceito de probabilidade em livros didáticos dos anos iniciais de escolarização. Como objetivos específicos, salientam-se: identificar as tarefas de probabilidade presentes nos livros; verificar quais demandas cognitivas estão presentes e identificar o tipo de experiência aleatória implicada nas tarefas e o tipo de contexto em que as tarefas foram formuladas. Foram analisadas quatro coleções de livros didáticos, aprovadas no Plano Nacional do Livro Didático 2016. Na análise foram identificadas 69 tarefas de probabilidade presentes nos livros do 1º ao 5º ano, tendo-se evidenciado que os livros didáticos orientam para a aprendizagem da probabilidade partindo das noções de aleatoriedade, perpassando pelo levantamento dos resultados de experimentos aleatórios e pela avaliação de probabilidades.Evidenciou-se, ainda, que nas tarefas identificadas nas coleções não se contempla o estudo da associação entre variáveis, outro aspecto importante no desenvolvimento do pensamento probabilístico. Finalmente, verificou-se a predominância de tarefas envolvendo experiências simples e formuladas no contexto de jogos de sorte e azar.
O NASCIMENTO DA DISCIPLINA DE MATEMÁTICA COMERCIAL E FINANCEIRA NO BRASIL (1905-1970)
Authors: Neto Sérgio Candido de Gouveia 
Published: June 2020

O presente trabalho tem como objetivo analisar como se deu o nascimento e a estabilização da disciplina de Matemática Comercial e Financeira no Brasil, relativos às quase sete primeiras décadas do século XX. Para atingir tal objetivo, utilizamos como fontes livros, textos legislativos e outros documentos sugeridos por Chervel (1990), ao trazer, em seu trabalho, reflexões sobre a história das disciplinas escolares como campo de pesquisa. Os resultados mostram que a disciplina de Matemática Comercial e Financeira teve como uma raiz, a disciplina de Aritmética dos cursoscomerciais, criados no início do século XX.
CARTAS DE REMY FREIRE PARA NEWTON DA COSTA
Authors: Neto Antonio Peixoto de Araujo , Trivizoli Lucieli M. 
Published: June 2020

Este trabalho de cunho qualitativo está inserido em uma pesquisa de doutorado finalizada em dezembro de 2019 no âmbito do Programa de Pós-Graduação em Educação para a Ciência e a Matemática (PCM) da Universidade Estadual de Maringá (UEM). Na referida pesquisa o foco foiinvestigar, historicamente, aspectos profissionais, a produção acadêmica do português João Remy Teixeira Freire (Remy Freire) e as suas contribuições para a Matemática e a Educação Matemática no Paraná. Para este texto, temos por objetivo explorar as correspondências de Remy Freire para Newton da Costa. Para tanto, utilizamos a pesquisa documental para embasar metodologicamente a transcrição e a análise de dez cartas de Remy Freire para Newton da Costa. As cartas estão localizadas dentre os documentos do Fundo Newton Carneiro Affonso da Costa sob responsabilidade dos Arquivos Históricos do Centro de Lógica, Epistemologia e História da Ciência da Universidade de Campinas (UNICAMP). De acordo com as nossas análises, observamos um perfil crítico, político e multifacetado de Remy Freire, no que tange nosso olhar para o cenário brasileiro e português da época e as múltiplas áreas de domínio de estudos e de sua atuação profissional.
PENGHINDARAN PAJAK: THIN CAPITALIZATION DAN ASSET MIX
Authors: Sueb Memed 
Published: June 2020

The purpose of this study was to examine the effect of thin capitalization, asset mix consist of capital intensity and inventory intensity to effective tax rates as the proxy for tax avoidance. Moderating variable used in this research is Index Saham Syariah Indonesia.The method used in this research is an analytical descriptive. The sample used in this research consist of 60 companies from manufacturing sector for Indonesia Shariah Stock Index in 2014 - 2017. Sample selection methods used in this research was purposive sampling. The analysis methods used in this research was Moderated Regression Analysis.The result of this study showed that thin capitalization has positive significant effect to effective tax rates as the proxy for tax avoidance. Capital intensity has positive effect and inventory intensity has negative effect to effective tax rates as the proxy for tax avoidance, but not significant. ISSI is not able to weaken the effect of thin capitalization, but able to weaken the effect of capital intensity and strengthen the effect of inventory intensity to tax avoidance. This research has R square value 33,4%
Antropofagia, influxos de mídia e consumo:
Authors: Bona Rafael Jose 
Published: June 2020

O antigo quarteto formado por Didi, Dedé, Mussum e Zacarias, conhecido por Os Trapalhões, teve importante trajetória na mídia brasileira ao estar presente, principalmente, na televisão, no cinema e nos quadrinhos. O objetivo deste artigo é fazer um percurso histórico acerca da franquia cinematográfica de Os Trapalhões, iniciada com o filme Na onda do iê-iê-iê (1965, Aurélio Teixeira) até a última produção, Os saltimbancos Trapalhões: rumo a Hollywood (2017, João Daniel Tikhomiroff). No presente trabalho são identificadas todas as produções cinematográficas do grupo e seus respectivos diretores de 1965 a 2017; e são atualizadas as ordenações temáticas dos filmes do quarteto, propostas por Ramos (1995, 2004) e Lunardelli (1996). Como principal resultado se constata que as narrativas, de quase todos os filmes da franquia do grupo, são alicerçadas a partir de questões antropofágicas, assim como possuem forte influxo midiático oriundo das obras televisivas nacionais e do cinema estadunidense, que despertam para o consumo destas referências e das demais obras de Os Trapalhões.