bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol and Celastrol Loaded Collagen Dental Implants Regulate Periodontal Ligament Fibroblast Growth and Osteoclastogenesis of Bone Marrow Macrophages
Authors: Wang Ruijie , Bao Bin , Bao Chunling , Wang Shujun , Ur Rahman Saeed , Hou Chunyu , Elango Jeevithan , Wu Wenhui 
Published: July 2020

AbstractCollagen is widely used for dental therapy in several ways such as films, 3D matrix, and composites, besides traditional Chinese medicine (TCM), has been used in tissue regeneration and wound healing application for centuries. Hence, the present study was targeted for the first time to fabricate collagen film with TCM such as resveratrol and celastrol in order to investigate the human periodontal ligament fibroblasts (HPLF) growth and bone marrow macrophages (BMM) derived osteoclastogenesis. Further, the physicochemical, mechanical and biological activities of collagen‐TCM films crosslinked by glycerol and EDC‐NHS (1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide‐N‐hydroxysulfosuccinimide) were investigated. Collagen film characterization was significantly regulated by the nature of plasticizers like hydrophobic and degree of polarity. Interestingly, the collagen film's denaturation temperature was increased by EDC‐NHS than glycerol. FT‐IR data confirmed the functional group changes due to chemical interaction of collagen with TCM. Morphological changes of HPLF cells cultured in control and collagen films were observed by SEM. Importantly, the addition of resveratrol upregulated the proliferation of HPLF cells, while osteoclastogenesis of BMM cells treated with mCSF‐RANKL was significantly downregulated by celastrol. Accordingly, the collagen‐TCM film could be an interesting material for dental regeneration, and especially it is a therapeutic target to restrain the elevated bone resorption during osteoporosis.
Expansion of the Na3MIII(Ln/An)6F30 Series: Incorporation of Plutonium into a Highly Robust and Stable Framework
Authors: Pace Kristen A. , Klepov Vladislav V. , Deason Travis K. , Smith Mark D. , Ayer Gyanendra B. , Diprete David P. , Amoroso Jake W. , zur Loye Hans‐Conrad 
Published: July 2020

AbstractNanMAn6F30 is an extremely versatile framework structure for incorporating tetravalent actinides (An) and cerium along with divalent or trivalent d‐metals (M); moreover, the structure exhibits a high resistance to harsh chemical conditions. This extreme robustness can potentially be exploited for the sequestration of plutonium in a stable matrix; however, no NanMPu6F30 compounds have been reported so far. Herein, we present four new plutonium fluorides that have been prepared as single crystals by mild hydrothermal synthesis methods. Structural characterizations revealed their compositions to be Na3AlPu6F30, Na3FePu6F30, Na3CoPu6F30, and Na2.4Mn1.6Pu6F30. Surprisingly, in the plutonium series, it was found that Co2+ and Mn2+ precursors oxidized to form Na3CoIIIPu6F30 and Na2.4MnII/III1.6Pu6F30, whereas the analogous reactions for cerium result in reduction of the transition metal, even when beginning with a M3+ precursor. While cerium is often used as a surrogate for plutonium, this work serves as an example that deviations between their chemistries do occur.
A Triptycene‐Based Enantiopure Bis(Diazadibenzoanthracene) by a Chirality‐Assisted Synthesis Approach
Authors: Wang Xubin , Kohl Bernd , Rominger Frank , Elbert Sven M. , Mastalerz Michael 
Published: July 2020

AbstractBy applying a chirality‐assisted synthesis (CAS) approach enantiopure diaminodibromotriptycenes were converted to rigid chiral helical diazadibenzoanthracenes, which show besides pronounced Cotton effects in circular dichroism spectra higher photoluminescence quantum yields as comparable carbacyclic analogues. For the enantiopure building blocks, a protocol was developed allowing the large scale synthesis without the necessity of separation via HPLC.
A Molecular Capsule with Revolving Doors Partitioning Its Inner Space
Authors: Lei Zhiquan , Finnegan Tyler J. , Gunawardana Vageesha W. Liyana , Pavlović Radoslav Z. , Xie Han , Moore Curtis E. , Badjić Jovica D. 
Published: July 2020

AbstractCovalent capsule 1 was designed to include two molecular baskets linked with three mobile pyridines tucked into its inner space. On the basis of both theory (DFT) and experiments (NMR and X‐ray crystallography), we found that the pyridine “doors” split the chamber (380 Å3) of 1 so that two equally sizeable compartments (190 Å3) became joined through a conformationally flexible aromatic barrier. The compartments of such unique host could be populated with CCl4 (88 Å3; PC=46 %), CBr4 (106 Å3; 56 %) or their combination CCl4/CBr4 (PC=51 %), with thermodynamic stabilities ΔG° tracking the values of packing coefficients (PC). Halogen (C−X⋅⋅⋅π) and hydrogen bonding (C−H⋅⋅⋅X) contacts held the haloalkane guests in the cavities of 1. The consecutive complexations were found to occur in a negative allosteric manner, which we propose to result from the induced‐fit mode of complexation. Newly designed 1 opens a way for probing the effects of inner conformational dynamics on noncovalent interactions, reactivity and intramolecular translation in confined spaces of hollow molecules.
Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate
Authors: Mohamed Mohamed‐Eslam F. , Minocha Mukul , Trueman Sheryl , Feng Tian , Enejosa Jeffrey , Fisniku Ogert , Othman Ahmed A. 
Published: July 2020

AbstractThis phase 1 study characterized the effect of multiple doses of upadacitinib, an oral Janus kinase 1 selective inhibitor, on the pharmacokinetics of the cytochrome P450 (CYP) 2B6 substrate bupropion. Healthy subjects (n = 22) received a single oral dose of bupropion 150 mg alone (study period 1) and on day 12 of a 16‐day regimen of upadacitinib 30 mg once daily (study period 2). Serial blood samples for measurement of bupropion and hydroxybupropion plasma concentrations were collected in each study period. The central values (90% confidence intervals) for the ratios of change were 0.87 (0.79‐0.96) for bupropion maximum plasma concentration (Cmax), 0.92 (0.87‐0.98) for bupropion area under the plasma‐concentration time curve from time 0 to infinity (AUCinf), 0.78 (0.72‐0.85) for hydroxybupropion Cmax, and 0.72 (0.67‐0.78) for hydroxybupropion AUCinf when administered with, relative to when administered without, upadacitinib. After multiple‐dose administration of upadacitinib 30 mg once daily, upadacitinib mean ± SD AUC0‐24 was 641 ± 177 ng·h/mL, and Cmax was 83.3 ± 30.7 ng/mL. These results confirm that upadacitinib has no relevant effect on pharmacokinetics of substrates metabolized by CYP2B6.
Recent Advances in Graphene Patterning
Authors: Wei Tao , Bao Lipiao , Hauke Frank , Hirsch Andreas 
Published: July 2020

AbstractAs an emerging field of research, graphene patterning has received considerable attention because of its ability to tailor the structure of graphene and the respective properties, aiming at practical applications such as electronic devices, catalysts, and sensors. Recent efforts in this field have led to the development of a variety of different approaches to pattern graphene sheets, providing a multitude of graphene patterns with different shapes and sizes. These established patterning techniques in combination with graphene chemistry have paved the road towards highly attractive chemical patterning approaches, establishing a very promising and vigorously developing research topic. In this review, an overview of commonly used strategies is presented that are categorized into top‐down and bottom‐up routes for graphene patterning, focusing mainly on new advances. Other than the introduction of basic concepts of each method, the advantages/disadvantages are compared as well. In addition, for the first time, an overview of chemical patterning techniques is outlined. At the end, the challenges and future perspectives in the field are envisioned.
Deep‐UV Lithography of Nanocomposite Thin Films into Magnetooptical Gratings with Submicron Periodicity
Authors: Bidaud Clémentine , Gamet Emilie , Jamon Damien , Vidal Loïc , Neveu Sophie , Soppera Olivier , Royer François , Berling Dominique 
Published: July 2020

AbstractIncompatibility of conventional magneto‐optical (MO) materials with photonic‐system fabrication processes constitutes a major technological roadblock limiting their integration into photonic devices, especially for micro‐ or nano‐patterned films. This paper proposes a photolithography approach toward MO micro‐ and nano‐patterns, based on hybrid photosensitive matrices doped with magnetic nanoparticles to concentrations as high as 20 % vol. The as‐prepared and characterized nanocomposite thin films exhibit excellent MO properties: a high Faraday rotation (3300°/cm), comparable with the best existing materials that nevertheless require much more involved processes. The photosensitive matrices allow patterned gratings with a wide range of periods (100 μm to 500 nm), using a simple procedure at room temperature. The fabricated gratings exhibit well‐defined regular structures and resolutions suitable for optical applications, including those at telecommunications wavelengths. Finally, direct applications of the proposed material and its associated process are demonstrated on two examples: 1) a magneto‐optical grating in free‐space and 2) in combination with a waveguide. The obtained optical and MO results are consistent with simulations.
Network communication monitoring system of distributed PV power generation system
Authors: Zhu Huimin , Yuan Shun , Li Chunlai 
Published: July 2020

SummaryEnergy is the cornerstone of the existence and development of modern society. The energy consumption continues to increase, and the ensuing environmental pollution and increasing lack of traditional energy sources have also become the world's most concerned issues. The emergence of new energy has eased the current unfavorable situation. Among them, distributed photovoltaic (PV) power generation has been favored because of its abundant resources and no geographical restrictions. However, due to the scattered construction of solar PV power stations, it is not easy to manage. Therefore, research and development of PV remote monitoring systems for unified monitoring and management of PV power stations. In addition, the problem of solar cell output efficiency is also an important reason that restricts the utilization of solar energy. Improving the output efficiency of the battery based on the existing solar cell conversion efficiency is also a focus of current research. Based on the above background, the research content of this article is the network communication monitoring system for distributed PV power generation systems. This article first conducts the overall design of the PV remote monitoring system, constructs the system's distributed design structure, and divides the underlying hardware part of the system into control modules and transmission. According to the application requirements, the STM32 series single‐chip microcomputer is selected as the controller of the system control module and the transmission module. The hardware circuit design and software process implementation of the system are studied to realize the data collection, MPPT control, and remote data transmission of the photovoltaic system. Features: Finally, through experimental simulation, it was verified that the light intensity increased from 600 to 800 W/m2, and the output current of the inverter increased accordingly. The output current of the distributed PV power generation system was directly proportional to the change of the light intensity. The designed system is feasible.
Security aware hybrid precoding based peak‐to‐average power ratio reduction Approaches for telecommunication systems
Authors: Sarkar Mrinmoy , Kumar Asok , Maji Bansibadan 
Published: July 2020

SummaryIn wireless telecommunication, one of the modulation approaches used is the orthogonal frequency division multiplexing (OFDM). Moreover, the high peak‐to‐average power ratio (PAPR) is the one notorious demerit in OFDM systems. Hence, the high power amplifier (HPA) is used in its linear region. Otherwise, the bit error rate (BER) will be increased. Several approaches are proposed in the wireless communications for reducing the PAPR issue. In this paper, we propose a hybrid Discrete Hartley Matrix Transform (DHMT) precoding using both selected mapping (SLM) and partial transmit sequence (PTS) PAPR reduction strategies. For the multicarrier modulation process, instead of Inverse Fast Fourier transform (IFFT) operation, the DHMT operation is used because of its low computational complexity. Based on multi‐chaotic, the time‐frequency domain encryption (TFDE) approach is adopted for physical layer security to confirm the security in data transmission. For enhancing the physical layer security, the proposed encryption system generates chaotic sequences based on Logistic maps and Lozi in the frequency and time domains together. In this study, the implementation of the DHMT‐based OFDM system is processed to reduce the maximum PAPR. Implementation is performed on the MATLAB platform, and the performances are calculated using complementary cumulative distribution function (CCDF), BER regards to signal‐to‐noise ratio (SNR), and the outputs are compared based on the computation time. However, compared with the existing models, the proposed model produced better PAPR minimization regarding SNR.
The conservation status and population decline of the African penguin deconstructed in space and time
Authors: Sherley Richard B. , Crawford Robert J. M. , de Blocq Andrew D. , Dyer Bruce M. , Geldenhuys Deon , Hagen Christina , Kemper Jessica , Makhado Azwianewi B. , Pichegru Lorien , Tom Desmond , Upfold Leshia , Visagie Johan , Waller Lauren J. , Winker Henning 
Published: July 2020

AbstractUnderstanding changes in abundance is crucial for conservation, but population growth rates often vary over space and time. We use 40 years of count data (1979–2019) and Bayesian state‐space models to assess the African penguin Spheniscus demersus population under IUCN Red List Criterion A. We deconstruct the overall decline in time and space to identify where urgent conservation action is needed. The global African penguin population met the threshold for Endangered with a high probability (97%), having declined by almost 65% since 1989. An historical low of ~17,700 pairs bred in 2019. Annual changes were faster in the South African population (−4.2%, highest posterior density interval, HPDI: −7.8 to −0.6%) than the Namibian one (−0.3%, HPDI: −3.3 to +2.6%), and since 1999 were almost −10% at South African colonies north of Cape Town. Over the 40‐year period, the Eastern Cape colonies went from holding ~25% of the total penguin population to ~40% as numbers decreased more rapidly elsewhere. These changes coincided with an altered abundance and availability of the main prey of African penguins. Our results underline the dynamic nature of population declines in space as well as time and highlight which penguin colonies require urgent conservation attention.
Highly Hydrophilic Polymer Composite Modified Electrode for Trace Copper Detection Based on Synergetic Electrostatic Attractions and Chelating Interactions
Authors: Wang Jianhui , Liu Donglin , Liu Yongle , Wang Faxiang , Huang Shouen , Luo Xin , Liu Dongmin , Chen Donger , Wei Jiaqian , Ning Jingheng 
Published: July 2020

AbstractA new electrochemical sensor for Cu2+ detection by square wave voltammetry with high sensitivity has been constructed, based on a composite of sodium carboxymethyl cellulose and Nafion. Starting from these two polymers that are rich of hydrophilic groups in backbones, a highly negative‐charged composite has been easily prepared, which displays outstanding ability to adsorb and enrich Cu2+ onto the electrode surface through both electrostatic attractions and chelating interactions. After optimizing test conditions, this new sensor exhibits a good linear signal response to Cu2+ in a concentration range from 1.0 nΜ to 50.0 nM with a limit of detection of 0.6 nM (S/N=3), as well as good anti‐interference for commonly co‐existing metal ions. Besides, this new electrochemical copper sensor has been successfully applied to detect trace Cu2+ in natural water samples with satisfactory recoveries of 98–104 %. These findings provide a new simple but effective way for the determination of heavy metal ions in environmental pollutants.
Single Chlamydomonas reinhardtii cell separation from bacterial cells and auto‐fluorescence tracking with a nanosieve device
Authors: Korensky Grant , Chen Xinye , Bao Mengdi , Miller Abbi , Lapizco‐Encinas Blanca , Park Myeongkee , Du Ke 
Published: July 2020

AbstractA planar, transparent, and adaptable nanosieve device is developed for efficient microalgae/bacteria separation. In the proposed method, a sacrificial layer is applied with dual photolithography patterning to achieve a 1D channel with a very low aspect ratio (1:10 000). A microalgae/bacteria mixture is then introduced into the deformable PDMS nanochannel. The hydrodynamic deformation of the nanochannel is regulated to allow the bacteria cells to pass through while leaving the microalgae cells trapped in the device. At a flow rate of 4 μL/min, the supernatant collected from the device is indistinguishable from a control solution, indicating that nearly all the microalgae cells are trapped in the device. Additionally, this device is capable of single cell auto‐fluorescence tracking. These microalgae cells demonstrate minimal photobleaching over 250 s laser exposure and could be used to monitor hazardous compounds in the sample with a continuous flow. This method will be valuable to purify microalgae samples containing contaminations and study single‐cell heterogeneity.
Alteration of methylation status in archival DNA samples: A qualitative assessment by methylation specific polymerase chain reaction
Authors: Iyer Gayatri Rangarajan , Hasan Qurratulain 
Published: July 2020

AbstractDNA methylation is an epigenetic mechanism that regulates gene expression, which also facilitates genomic imprinting. Genomic imprinting is responsible for differential expression of genes based on parent of origin. Altered methylation of parental alleles results in imprinting disorders diagnosed by methylation specific polymerase chain reaction (MS‐PCR) technique. With increasing evidence of genes under epigenetic influence, methylation studies are extensively performed on archival samples. To evaluate effect of storage and storage conditions on DNA methylation, a systematic MS‐PCR based analysis was planned on an imprinted gene, SNRPN, located on chromosome 15q11.2. It was assessed by MS‐PCR on fresh, 4 −20, and −80°C stored DNA samples for different time periods for systematic evaluation of methylation status. Technical factors like type of sample processing, method of DNA isolation, primer region polymorphism, sample heterogeneity were also evaluated. DNA methylation was observed to be altered for SNRPN gene after storage at −80°C from 2 months onwards. Long‐term storage of DNA at −80°C results in altered DNA methylation status. This may lead to false MS‐PCR diagnosis of imprinting disorders. Our proof of concept study should be followed with quantitative validation since the findings have critical implications in the present era of biobanking.
Internet of Things device authentication via electromagnetic fingerprints
Authors: Souza Artur , Carlson Ivo , Ramos Heitor S. , Loureiro Antônio A.F. , Oliveira Leonardo B. 
Published: July 2020

AbstractWe quickly approach a future where Internet of Things (IoT) devices are the norm. In this scenario, humans are surrounded by a multitude of heterogeneous devices that assist them in almost every aspect of their daily routines. The realization of this future demands strong authentication guarantees to ensure that these devices are not abused and that their users are not endangered. However, providing authentication for these systems is challenging due to the high heterogeneity of IoT applications. In this paper, we first review several IoT application scenarios and promising authentication methods for each. We identify th e key characteristics of each IoT application scenario, present the strengths and weaknesses of prominent authentication methods from the literature, and review which authentication methods have been proposed in the literature for each application. Then, we present a novel authentication method for IoT based on electromagnetic noise. The key advantage of electromagnetic noise is that any electronic device intrinsically generates electromagnetic noise during normal operation. We extract features from these electromagnetic emanations and use machine learning algorithms to identify devices based on these features. Our method achieves 77% accuracy when identifying devices among a set of seven devices.
Is Inciting Social Change Something Evaluators Can Do? Should Do?
Authors: Neubauer Leah C. , Hall Melvin E. 
Published: July 2020

AbstractThis volume set out to consider what must occur for evaluators and evaluation to incite social justice‐oriented change in the communities where there is a need. It takes an affirmative posture and, in each chapter, builds a case for engaging in social change. In a variety of contexts, exploration of the social consciousness of evaluators and the larger evaluation profession, has led to the encouraging possibility that promoting oppositional consciousness could more reliably lead to the desired change. However, some argue that moving evaluation in this direction is a mistake and goes too far. This chapter examines the cases that have been made for greater evaluator involvement in inciting social change and presents a rational for the who, what, where, and when of evaluator engagement in inciting social change. The chapter concludes with the expected value to society of this change in evaluator posture.
Petrographic and SEM‐EDX characterization of Mousterian white/beige chert tools from the Navalmaíllo rock shelter (Madrid, Spain)
Authors: Abrunhosa Ana , Bustillo María Ángeles , Pereira Telmo , Márquez Belén , Pérez‐González Alfredo , Arsuaga Juan Luis , Baquedano Enrique 
Published: July 2020

AbstractStudying lithic raw material sourcing, processing and distribution is helpful when trying to reconstruct the territory, ecology, and cultural practices of Neanderthal groups. The use of multiple methods in such analyses allows for more refined characterizations to be made, helping to distinguish between materials better than any single method. Although 85% of the raw materials making up the Mousterian assemblage at the Navalmaíllo Rock Shelter (Pinilla del Valle, Madrid Region of Spain) correspond to the available local geological resources, 10% is made of white/beige chert, which is not registered in regional geological cartography. Petrographic and scanning electron microscopy with energy dispersive X‐ray spectroscopy analyses were performed to determine the origin of this white/beige chert and thus shed light on the procurement strategies of the Neanderthal groups that occupied the rock shelter. The results show this chert to correspond to three different types of rock: quartz–kaolinite rocks from dykes, cretaceous marine cherts, and quartz fillings of cavities/fractures. These findings are in accordance with the geological features and formations present in the Lozoya valley, as recorded during a geoarchaeological survey, and indicate that the Neanderthals occupying the center of the Iberian Peninsula possessed a detailed knowledge of the landscape that allowed them to exploit its resources during MIS5a–early MIS4.