bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chandelier cell anatomy and function reveal a variably distributed but common signal
Authors: Schneider-Mizell Casey M. , Bodor Agnes L. , Collman Forrest , Brittain Derrick , Bleckert Adam A. , Dorkenwald Sven , Turner Nicholas L. , Macrina Thomas , Lee Kisuk , Lu Ran , Wu Jingpeng , Zhuang Jun , Nandi Anirban , Hu Brian , Buchanan JoAnn , Takeno Marc M. , Torres Russel , Mahalingam Gayathri , Bumbarger Daniel J. , Li Yang , Chartrand Tom , Kemnitz Nico , Silversmith William M. , Ih Dodam , Zung Jonathan , Zlateski Aleksandar , Tartavull Ignacio , Popovych Sergiy , Wong William , Castro Manuel , Jordan Chris S. , Froudarakis Emmanouil , Becker Lynne , Suckow Shelby , Reimer Jacob , Tolias Andreas S. , Anastassiou Costas , Seung H. Sebastian , Reid R. Clay , Maçarico da Costa Nuno 
Published: April 2020

AbstractThe activity and connectivity of inhibitory cells has a profound impact on the operation of neuronal networks. While the average connectivity of many inhibitory cell types has been characterized, we still lack an understanding of how individual interneurons distribute their synapses onto their targets and how heterogeneous the inhibition is onto different individual excitatory neurons. Here, we use large-scale volumetric electron microscopy (EM) and functional imaging to address this question for chandelier cells in layer 2/3 of mouse visual cortex. Using dense morphological reconstructions from EM, we mapped the complete chandelier input onto 153 pyramidal neurons. We find that the number of input synapses is highly variable across the population, but the variability is correlated with structural features of the target neuron: soma depth, soma size, and the number of perisomatic synapses received. Functionally, we found that chandelier cell activityin vivowas highly correlated and tracks pupil diameter, a proxy for arousal state. We propose that chandelier cells provide a global signal whose strength is individually adjusted for each target neuron. This approach, combining comprehensive structural analysis with functional recordings of identified cell types, will be a powerful tool to uncover the wiring rules across the diversity of cortical cell types.
Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan inDrosophila
Authors: Polan Danielle M , Alansari Mohammad , Lee Byoungchun , Grewal Savraj 
Published: April 2020

ABSTRACTIn many animals, short-term fluctuations in environmental conditions in early life often exert long-term effects on adult physiology. In Drosophila, one ecologically relevant environmental variable is hypoxia.Drosophilalarvae live on rotting, fermenting food rich in microorganisms – an environment characterized by low ambient oxygen. They have therefore evolved to tolerate hypoxia. While the acute effects of hypoxia in larvae have been well studied, whether early-life hypoxia affects adult physiology and fitness is less clear. Here we show that Drosophila exposed to hypoxia during their larval period subsequently show reduced starvation stress resistance and shorter lifespan as adults, with these effects being stronger in males. We find that these effects are associated with reduced whole-body insulin signaling but elevated TOR kinase activity, a manipulation known to reduce lifespan. We also identify a sexually dimorphic effect of larval hypoxia on adult nutrient storage and mobilization. Thus, we find that males, but not females, showing elevated levels of lipids and glycogen. Moreover, we see that both males and females exposed to hypoxia as larvae show defective lipid mobilization upon starvation stress as adults. These data show how early-life hypoxia can exert persistent, sexually dimorphic, long-term effects on Drosophila adult physiology and lifespan.
DriveWays: A Method for Identifying Possibly Overlapping Driver Pathways in Cancer
Authors: Baali Ilyes , Erten Cesim , Kazan Hilal 
Published: April 2020

AbstractMotivationThe majority of the previous methods for identifying cancer driver modules output non-overlapping modules. This assumption is biologically inaccurate as genes can participate in multiple molecular pathways. This is particularly true for cancer-associated genes as many of them are network hubs connecting functionally distinct set of genes. It is important to provide combinatorial optimization problem definitions modeling this biological phenomenon and to suggest efficient algorithms for its solution.ResultsWe provide a formal definition of the Overlapping Driver Module Identification in Cancer (ODMIC) problem. We show that the problem is NP-hard. We propose a seed-and-extend based heuristic named DriveWays that identifies overlapping cancer driver modules from the graph built from the IntAct PPI network. DriveWays incorporates mutual exclusivity, coverage, and the network connectivity information of the genes.We show that DriveWays outperforms the state-of-the-art methods in recovering well-known cancer driver genes performed on TCGA pan-cancer data. Additionally, DriveWays’s output modules show a stronger enrichment for the reference pathways in almost all cases. Overall, we show that enabling modules to overlap improves the recovery of functional pathways filtered with known cancer drivers, which essentially constitute the reference set of cancer-related pathways.AvailabilityThe data, the source code, and useful scripts are available at:https://github.com/abu-compbio/DriveWaysSupplementary informationSupplementary data are available atBiorxiv.
Chitosan primes plant defence mechanisms againstBotrytis cinerea, including expression of Avr9/Cf-9 rapidly-elicited genes
Authors: De Vega Daniel , Holden Nicola , Hedley Pete E , Morris Jenny , Luna Estrella , Newton Adrian 
Published: April 2020

AbstractCurrent crop protection strategies against the fungal pathogenBotrytis cinerearely on a combination of conventional fungicides and host genetic resistance. However, due to pathogen evolution and legislation in the use of fungicides, these strategies are not sufficient to protect plants against this pathogen. Defence elicitors can stimulate plant defence mechanisms through a phenomenon known as priming. Priming results in a faster and/or stronger expression of resistance upon pathogen recognition by the host. This work aims to study priming of a commercial formulation of the elicitor chitosan. Treatments with chitosan result in induced resistance in solanaceous and brassicaceous plants. In tomato plants, enhanced resistance has been linked with priming of callose deposition and accumulation of the plant hormone jasmonic acid (JA). Large-scale transcriptomic analysis revealed that chitosan primes gene expression at early time-points after infection. In addition, two novel tomato genes with a characteristic priming profile were identified, Avr9/Cf-9 rapidly-elicited protein 75 (ACRE75)and 180(ACRE180). Transient and stable overexpression ofACRE75, ACRE180and theirNicotiana benthamianahomologs, revealed that they are positive regulators of plant resistance againstB. cinerea. This provides valuable information in the search for strategies to protect Solanaceae plants againstB. cinerea.
Analysis of biosynthesis and composition of cuticular wax in wild type bilberry (Vaccinium myrtillusL.) and its glossy mutant
Authors: Trivedi Priyanka , Nguyen Nga , Klavins Linards , Kviesis Jorens , Heinonen Esa , Remes Janne , Jokipii-Lukkari Soile , Klavins Maris , Karppinen Katja , Jaakola Laura , Häggman Hely 
Published: April 2020

AbstractCuticular wax plays an important role in fruits in protection against environmental stresses and desiccation. In this study, biosynthesis and chemical composition of cuticular wax in wild type (WT) bilberry fruit was studied during development and compared with its natural glossy type (GT) mutant. The cuticular wax load in GT fruit was comparable to WT fruit. In both fruits, triterpenoids were the dominant wax compounds with decreasing proportion during the fruit development accompanied with increasing proportion of aliphatic compounds. Gene expression studies supported the pattern of compound accumulation during fruit development. GenesCER26-like, FAR2, CER3-like, LTP, MIXTA, andBASexhibited prevalent expression in fruit skin indicating role in cuticular wax biosynthesis and secretion. In GT fruit, higher proportion of triterpenoids in cuticular wax was accompanied by lower proportion of fatty acids and ketones compared to WT fruit as well as lower density of crystalloid structures on berry surface. Our results suggest that a marked reduction in ketones in cuticular wax may play a significant role in the formation of glossy phenotype leading to the loss of rod-like structures in epicuticular wax layer of GT fruit.HighlightChemical composition and morphology of cuticular wax along with gene expression for wax biosynthetic genes varied between glossy type mutant (GT) and wild type (WT) fruit.
In the field of tension between creativity and efficiency: a systematic literature review of management control systems for innovation activities
Authors: Lill Philipp , Wald Andreas , Munck Jan Christoph 
Published: April 2020

PurposeThe number of theoretical and empirical research on management control of innovation activities has significantly increased. Existing studies in this field are characterized by a wide dispersion and a multitude of different definitions. The purpose of this article is to provide a systematic review of the literature on management control of innovation activities and to synthesize the current body of knowledge.Design/methodology/approachFollowing a systematic review approach, this article reviews 79 articles on management control for innovation activities from 1959 to 2019 and inductively derives a multi-dimensional framework.FindingsThe review of existing studies advances the debate about the detrimental versus beneficial character of management control systems for innovation, showing that the repressing character of control is not inherent to control itself, but emanates from the design of the respective management control system.Research limitations/implicationsThe multi-dimensional framework connects and combines existing research and thus synthesizes the current state of knowledge in this field. Additionally, the framework can guide practitioners to systematically assess context factors and consequences of their management control systems design, and it shows avenues for future research.Originality/valueThe scientific and practical value of this paper is the convergence of the current body of knowledge consisting of various definitions and conceptualizations and the identification of avenues for future research.
CEO inside debt and corporate social responsibility
Authors: Sheikh Shahbaz 
Published: April 2020

PurposeThe purpose of this paper is to empirically examine the relation between incentives from CEO inside debt (deferred compensation and pension benefits) and corporate social responsibility (CSR).Design/methodology/approachInstrumental variable (IV-GMM) regressions are used to estimate the relation between CEO inside debt and CSR.FindingsThe results of this paper indicate that CEOs with large inside debt tend to invest more in CSR. Analysis of CSR strengths and concerns supports this finding and shows that CEO inside debt is significantly positively (negatively) associated with CSR strengths (concerns). Further tests indicate that CEO inside debt exerts a positive and significant effect on all five dimensions of social performance (diversity, community, product, employee relations and environment).Research limitations/implicationsThe results of this study are based on US corporations. Future research should investigate if these results hold for firms in other countries in order to better our understanding of the relation between CEO inside debt and CSR.Practical implicationsCEOs use CSR as a risk management strategy to reduce corporate risk in order to protect the value of their inside debt.Social implicationsThe results in this paper provide a practical tool to boards of corporations to increase investment in CSR. The results suggest that boards can encourage CEOs to invest in CSR by increasing incentives from inside debt.Originality/valueThis study contributes to the literature that examines the relation between inside debt and CSR by showing that CEO inside debt exerts a positive impact on CSR.
The end of the Multi Fiber Arrangement and the pattern of US apparel trade
Authors: Datta Anusua , Kouliavtsev Mikhail 
Published: April 2020

PurposeThis paper analyzes the effects of the expiration of the Multi Fiber Arrangement (MFA), which ended quota restrictions on US textile and apparel imports in 2005, on the sourcing of US apparel. We test if the realignment in trade following the phase out of quotas can be explained by comparative advantage and market size.Design/methodology/approachWe use a gravity framework to investigate the role of comparative advantage (labor costs) and other factors such as exporter size, PTAs and tariff reductions on the pattern of US apparel imports. Detailed data on quotas by country-product pair are used for the purpose.FindingsOur empirical results show a significant increase in imports from large quota constrained countries once the MFA ended. Moreover, the pattern of trade seems to favor low wage countries that have a comparative advantage in producing apparel, which is highly labor intensive.Originality/valueThe end of quotas removed a major distorting factor in US apparel trade. This study examines the role of trade theory in the changing pattern of apparel imports that followed the end of the MFA. We use a gravity framework to test the theory of comparative advantage and the role of exporter size. Previous studies on the end of the MFA and its effects, do not examine the causal factors behind the realignment of US apparel trade.
A framework for technology transfer success factors: validation for the Graphene4Life project
Authors: Chiș Diana-Maria , Crișan Emil Lucian 
Published: April 2020

PurposeThe purpose of this paper is to develop a theoretical framework for technology transfer success factors from a technology provider viewpoint and to test this framework considering the perceptions of graphene researchers from a Romanian research project (Graphene4Life).Design/methodology/approachThe authors conducted a literature review and a case study with three units of analysis. Semi-structured face-to-face interviews and content analysis were used.FindingsThe five-category framework for technology transfer success factors from a technology provider viewpoint, which portrays success factors in an expansive way from technology to the market (technology, organization, context, collaboration and customer absorptive capacity factors), is confirmed by the qualitative analysis, while new factors in all categories are discovered.Research limitations/implicationsThe results are limited given the qualitative nature of this research. The extrapolation of the results to other technologies and contexts is a scientific challenge.Originality/valueIn this paper, the authors develop, based on a detailed literature review, a framework for technology success factors from a technology provider viewpoint, which classifies technology transfer success factors in an expansive way from technology to the market (technology, organization, context, collaboration and customer absorptive capacity factors). Technology itself is settled as the foundation of the framework, underlining the need for a technology-driven technology transfer process. In comparison to existing frameworks that analyze technology transfer success factors, the present framework is a more complex one, covering all facets of the technology process. The new factors discovered through the qualitative analysis are also an important contribution of this research.
Impact of entrepreneurial leadership on project success: mediating role of knowledge management processes
Authors: Latif Khawaja Fawad , Nazeer Aqib , Shahzad Faisal , Ullah Mohsin , Imranullah Muhammad , Sahibzada Umar Farooq 
Published: April 2020

PurposeDrawing on the knowledge-based view (KBV), the study investigates the impact of entrepreneurial leadership (EL) on knowledge management (KM) processes and further examines the mediating role of KM processes on the linkage between EL and project success (PS).Design/methodology/approachSurvey data were collected from 304 project workers in software projects, and the proposed relationships were assessed through SMART-PLS structural equation modeling tool.FindingsThe study found a significant impact of EL on KM processes and PS. The analysis also revealed that KM processes significantly impact project success while EL impact PS indirectly through KM processes.Originality/valueThe relevancy of the research stems from the scarcity of research on EL, while studies on the role of leadership as a predictor of KM are significantly limited. Additionally, there is a scarcity of research on the impact of KM on project success. This is one of the earliest studies that investigate the inter-relationship among EL, KM processes and project success.
Hub firm transformation and industry cluster upgrading: innovation network perspective
Authors: Ye Di , Wu Yenchun Jim , Goh Mark 
Published: April 2020

PurposeThis research paper examines how hub firm transformation and restructuring of network partnerships shape the development of industrial clusters in China.Design/methodology/approachQuestionnaire data were collected from 210 managers (response rate 70.9 percent) from the manufacturing industrial clusters in Eastern China.FindingsThe results inform that a cluster’s hub firm transformation influences the evolution of the cluster. Though the hub firm may possess transformation capabilities, the cluster is likely to be weakened if network partnerships and resource synergy are not formed amongst the cluster members.Research limitations/implicationsThis paper, in examining the individual- and firm-level attributes of orchestration capability and their interactions, sheds light on the firm level and inter-firm level relationships between resources and innovation in an industrial cluster.Practical implicationsTo facilitate learning and the upgrading of firms within an industry cluster and promote a cluster’s innovation network, policymakers can initiate preferential policy measures to cultivate support to strategically transform a cluster’s hub firm, thus fostering cluster network growth.Originality/valueThe paper studies the evolution of clusters by investigating the hub firm transformation and member firm interaction. Focusing on the inter-firm network interactions lends a richer understanding of the nuances of the evolution of industrial clusters in Asia.
Antenatal magnesium sulphate for the prevention of cerebral palsy in infants born preterm: a double‐blind, randomised, placebo‐controlled, multi‐centre trial
Authors: Wolf HT , Brok J , Henriksen TB , Greisen G , Salvig JD , Pryds O , Hedegaard M , Weber T , Hegaard HK , Pinborg A , Huusom LD ,   The MASP research group
Published: April 2020

ObjectiveTo study the effect of antenatal magnesium sulphate (MgSO4) on cerebral palsy (CP) in a manner that also provides adequate power for a linked trial sequential analysis.DesignDouble‐blind, randomised, placebo‐controlled, multi‐centre trial.SettingFourteen Danish obstetric departments.PopulationIn total, 560 pregnant women at risk for preterm delivery before 32 weeks of gestation were randomised from December 2011 to January 2018. Those women gave birth to 680 children.MethodsWomen were randomised to receive either a loading dose of 5 g MgSO4 followed by 1 g/hour or a placebo in identical volumes. The children were followed up at a corrected age of 18 months or older with a review of their medical charts and with the Ages and Stages Questionnaire.Main outcome measureThe primary outcome measure was moderate to severe CP. Secondary outcomes included mortality, neonatal morbidity, blindness and mild CP.ResultsThe crude rates of moderate to severe CP in the MgSO4 group and the placebo group were 2.0% and 3.3%, respectively. The adjusted odds of moderate to severe CP were lower in the MgSO4 group than in the placebo group (odds ratio 0.61; 95% CI 0.23–1.65).ConclusionsAntenatal MgSO4 before 32 weeks of gestation decreases the likelihood of moderate to severe CP; these results are entirely consistent with other randomised evidence summarised in the linked trial sequential analysis.Tweetable abstractAntenatal magnesium sulphate may decrease the risk of moderate to severe cerebral palsy in children born before 32 weeks of gestation.
Clinical characteristics and risk factors of drug‐induced lung injury by ALK tyrosine kinase inhibitors: A single center retrospective analysis
Authors: Koshikawa Ken , Terada Jiro , Abe Mitsuhiro , Iwasawa Shunichiro , Sakayori Masashi , Yoshioka Keiichiro , Hirasawa Yasutaka , Kasai Hajime , Kawasaki Yohei , Tsushima Kenji , Tatsumi Koichiro 
Published: April 2020

AbstractBackgroundIf anaplastic lymphoma kinase (ALK) gene rearrangement in lung cancer is identified, ALK‐tyrosine kinase inhibitors (ALK‐TKIs) can be an effective treatment. However, the details of drug‐induced lung injury (DILI) caused by ALK‐TKI, which can be a serious side effect of ALK‐TKIs, remains unclear. This study aimed to investigate the clinical features and the onset risk factors of DILI by ALK‐TKIs in clinical practice.MethodsThe clinical features of 56 consecutive patients who received crizotinib, alectinib, and/or ceritinib at our hospital from 2012 to 2018 were retrospectively examined. Among these, patients diagnosed with DILI due to ALK‐TKIs were evaluated in terms of clinical features and parameters. Each clinical parameter before the administration of ALK‐TKIs was compared between the DILI onset group and the non‐onset group.ResultsA total of seven cases were diagnosed with DILI due to ALK‐TKIs; no DILI‐related deaths were observed. Chest computed tomography (CT) scan findings identified six patients with the organizing pneumonia (OP) pattern and one with the hypersensitivity pneumonia pattern. The onset of DILI was significantly different in patients age ≥ 64 years and with a creatinine clearance <80 mL/minute.ConclusionsExtra caution for DILI due to ALK‐TKIs may be needed when recommending ALK‐TKIs for patients over 64 years of age, or with decreased renal function. CT images of the majority of patients with DILI by ALK‐TKIs show an OP pattern.Key points
Significant findings of the study: Extra caution is needed when recommending ALK‐TKIs for patients over 64 years of age or those with decreased renal function. Computed tomography images of the majority of patients with DILI by ALK‐TKIs show an OP pattern.
What this study adds: The same or a different ALK‐TKI may be considered as a treatment option after the onset of DILI, based on careful judgment.