bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online Patient Consultation
Authors: Juhra Christian , Ansorg Jörg , Back David Alexander , John Dominik , Kuckuck-Winkelmann Andrea , Raschke Michael , Osterhoff Georg , Pförringer Dominik , Scherer Julian 
Published: August 2020

AbstractNew communication technologies allow patients to communicate with their physicians from anywhere using computer or smartphone. Adding video to the mere phone call optimizes the personal contact between patient and physicians regardless of distance. Legal and reimbursements requirements must be taken into account, especially only certified software products must be used. In addition, patient consent is needed and confidentiality must be assured. The video patient consultation can be reimbursed by the health insurance companies. As with all new technologies, the introduction of these video consultations faced some challenges. Although patients and physicians have expressed great interest in this technology, it has been rarely used so far. The current COVID crisis increased the need for video consultations resulting in an increasing use of video patient consultation. It can be expected that this demand will still exists after the COVID crisis.
Kalziumkristalle im Gelenk
Authors: Märtens Nicole , Bertrand Jessica 
Published: August 2020

ZUSAMMENFASSUNGEs gibt im Wesentlichen 2 Arten von Kalziumkristallen im Gelenk. Zum einen gibt es Kalziumphosphatkristalle (BCP) und zum anderen gibt es Kalziumpyrophosphatkristalle (CPPD). BCP-Kristalle sind mit der Arthrose assoziiert und entstehen durch die hypertrophe Differenzierung von Chondrozyten. CPPD-Kristalle sind mit der Chondrokalzinose assoziiert. Hier ist die Entstehung noch nicht vollständig verstanden. Die Kalziumkristalle lösen eine entzündliche Reaktion im Gelenk aus und induzieren die Sekretion von proinflammatorischen Zytokinen. Unterschiedliche direkte oder indirekte Signalwege sind hierfür bereits beschrieben worden und werden im Text näher erläutert. Die bisherigen Therapien greifen hauptsächlich in das Entzündungsgeschehen ein. Es gibt bisher wenige Ansätze einer gezielten Kristall-abhängigen oder insbesondere Kristall-auflösenden Therapie. Durch besseres Verständnis der zu Grunde liegenden Signalwege wird in Zukunft eventuell eine derartige Therapie zur Verfügung stehen, sodass gezielt die Kalziumkristalle aufgelöst oder die spezifischen Signalwege inhibiert werden können.
Digitale Missachtung der Bedürfnisse und Rechte von Kindern und Jugendlichen: Cybermobbing
Authors: Möhler Eva , Ohmann Susanne , Popow Christian , Paulus Frank W. 
Published: August 2020

ZUSAMMENFASSUNGMobbing beinhaltet aggressive Handlungen mit dem Ziel, eine andere Person zu verletzen, zu demütigen oder einzuschüchtern. Die digitale Revolution hat die Möglichkeiten des klassischen Mobbings erweitert. Täter können anonym bleiben, körperliche Überlegenheit ist nicht notwendig, ein größeres Publikum kann erreicht werden, Nachrichten sind unbegrenzt speicherbar und nicht zurücknehmbar. Cybermobbing hat schwerwiegende Probleme für Opfer bzw. Täter zur Folge und beeinträchtigt deren physische und psychische Gesundheit, ihre sozialen Beziehungen und ihre Lebensqualität. Folgen können bei Opfern Depressionen, Ängste, PTBS, intensiver Stress, Schlafstörungen, Selbstverletzungen, Suizidalität und Suizid sein. Die komorbiden psychischen Störungen sind so früh wie möglich zu erkennen und angemessen zu behandeln. Wirksame Maßnahmen zur Prävention sind verfügbar, werden jedoch nicht ausreichend intensiv und flächendeckend durchgeführt. Anti-Mobbing-Maßnahmen verhindern nicht nur (Cyber-)Mobbing, sondern tragen auch zu einem besseren schulischen und innerfamiliären Klima bei und begünstigen Einstellungen gegen Mobbing und die Lebensqualität von Beteiligten.
Nonketotic Hyperglycinemia in Tunisia. Report upon a Series of 69 Patients
Authors: Nasrallah Fahmi , Hadj-Taieb Sameh , Chehida Amel Ben , Jelassi Awatef , Ben Massoued Sana , Charfi Manel , Zidi Wiem , Amri Fethi , Helel Khaled Ben , Mejaoual Houssain , Seboui Hassen , Mahdhaoui Nabiha , Gargouri Abdellatif , Monastiri Kamel , Turki Ilhem , Cheour Myriam , Sanhaji Haifa , Tebib Neji , Feki Moncef , Kaabachi Naziha 
Published: August 2020

Abstract
Aim The aim of the study is to report on epidemiological, clinical, and biochemical characteristics of nonketotic hyperglycinemia (NKH) in Tunisia.
Methods Patients diagnosed with NKH in Laboratory of Biochemistry at Rabta hospital (Tunis, Tunisia) between 1999 and 2018 were included. Plasma and cerebrospinal fluid (CSF) free amino acids were assessed by ion exchange chromatography. Diagnosis was based on family history, patient's clinical presentation and course, and increased CSF to plasma glycine ratio.
Results During 20 years, 69 patients were diagnosed with NKH, with 25 patients originating from Kairouan region. Estimated incidences were 1:55,641 in Tunisia and 1:9,684 in Kairouan. Consanguinity was found for 73.9% of the patients and 42% of the families have history of infantile death due to a disease of similar clinical course than the propositus. Clinical symptoms initiated within the first week of life in 75% of the patients and within the first 3 months in 95.7% ones. The phenotype was severe in 76.8% of the patients. Main symptoms were hypotonia, feeding difficulties, coma, apnea, and seizures. Most patients died within few days to months following diagnosis. CSF to plasma glycine ratio was increased in all patients. CSF and plasma glycine levels were negatively correlated with age of disease onset and severity.
Conclusion NKH is quite frequent in Tunisia. Kairouan region has the highest NKH incidence rate, worldwide. However, due to lack of confirmatory enzymatic and genetic tests, NKH diagnosis was based on first-line biochemical tests. Characterization of causal mutations is needed for accurate diagnosis and prenatal diagnosis of this devastating life-threatening disease.
Reloadable Stapler Use during Peripartum Hysterectomy for Placenta Accreta Spectrum: A Novel Surgical Technique and Case Series
Authors: Smith Christopher G. , Cottrill Hope M. , Barton John R. 
Published: August 2020

Objective This study aimed to describe a novel surgical technique for the management of antenatally suspected placenta accreta spectrum (PAS).
Study Design This is a retrospective, case series of patients with suspected PAS undergoing peripartum hysterectomy with a reloadable articulating stapler at a tertiary care center.
Results Eighteen patients with antenatally suspected PAS were identified and underwent peripartum hysterectomy with the aid of a reloadable stapler. Mean gestational age at delivery was 344/7 ± 11/7 weeks. Mean total operative time (skin-to-skin) was 117.3 ± 39.3 minutes, and 79.8 ± 19.8 minutes for the hysterectomy. Mean blood loss for the entire case was 1,809 ± 868 mL. Mean blood loss for the hysterectomy was 431 ± 421 mL. Mean units of intraoperative red blood cells transfused was 3 ± 1 units. Mean units of postoperative red blood cells transfused was 1 ± 0.5 units. Five cases were complicated by urological injury (two intentional cystotomies). Four patients were admitted to the intensive care unit (ICU) for a mean of ≤24 hours. Mean postoperative LOS was 4.11 ± 1.45 days. Three patients had final pathology that did not demonstrate PAS while four were consistent with accreta, six increta, and five percreta.
Conclusion Use of a reloadable articulating stapler device as part of the surgical management of antenatally suspected PAS results in a shorter operative time (117 ± 39 minutes vs. 140–254 minutes previously reported), lower average blood loss (1,809 ± 868 mL vs. 2,500–5,000 mL previously reported) and shorter LOS (4.11 ± 1.45 days vs. 9.8 ± 13.5 days previously reported) compared with traditional cesarean hysterectomy. The reloadable stapling device offers an advantage of more rapidly achieving hemostasis in the surgical management of PAS.
Key Points
Patient-Reported Health Outcomes and Quality of Life after Peripartum Hysterectomy for Placenta Accreta Spectrum
Authors: Grover Bryan , Einerson Brett D. , Keenan Karissa D. , Gibbins Karen J. , Callaway Emily , Lopez Sarah , Silver Robert M. 
Published: August 2020

Objective Short-term morbidity of placenta accreta spectrum (PAS) is well described, but few data are available regarding long-term outcomes and quality of life. We aimed to evaluate patient-reported outcomes after hysterectomy for PAS.
Study Design This is a prospective cohort study of women with risk factors for PAS who were enrolled antenatally. Exposed women were defined as those who underwent cesarean hysterectomy due to PAS. Unexposed women were those with three or more prior cesareans or placenta previa, but no PAS, who underwent cesarean delivery without hysterectomy. Two surveys were sent to patients at 6, 12, 24, and 36 months postpartum: (1) a general health questionnaire and (2) the SF-36, a validated quality of life survey. Aggregate scores for each questionnaire were calculated and responses were analyzed.
Results At 6 months postpartum, women with PAS were more likely to report rehospitalization (odds ratio [OR] 5.83, 95% confidence interval [CI] 1.40–24.3), painful intercourse (OR 2.50, 95% CI 1.04–6.02), and anxiety/worry (OR 3.77, 95% CI 1.43–9.93), but were not statistically more likely to report additional surgeries (OR 3.39, 95% CI 0.99–11.7) or grief and depression (OR 2.45, 95% CI 0.87–6.95). At 12 months, women with PAS were more likely to report painful intercourse, grief/depression, and anxiety/worry. At 36 months, women with PAS were more likely to report grief/depression, anxiety/worry, and additional surgeries. Women with PAS reported significantly lower quality of life in physical functioning, role functioning, social functioning, and pain at 6 months postpartum, but not in other quality of life domains. Decreased quality of life was also reported at 12 and 36 months in the PAS group.
Conclusion Women with PAS are more likely to report ongoing long-term health issues and decreased quality of life for up to 3 years following surgery than those undergoing cesarean for other indications.
Key Points
KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence
Authors: Juillard Franceline , de Miranda Marta Pires , Li Shijun , Franco Aura , Seixas André F. , Liu Bing , Álvarez Ángel L. , Tan Min , Szymula Agnieszka , Kaye Kenneth M. , Simas J. Pedro 
Published: August 2020

Significance
Understanding how viruses modulate host cell function is central to prospects for potential therapies. A recently described mechanism mediates selective protein interactions between acidic domain readers and unacetylated, lysine-rich regions, opposite of bromodomain function. Here we show that the latency-associated nuclear antigen (LANA) encoded by Kaposi´s sarcoma-associated herpesvirus (KSHV) contains a SET oncoprotein homologous acidic domain reader that interacts with p53 in an acetylation-dependent manner. Significantly, the LANA acidic domain reader is critical for viral latency and persistent infection. The finding that KSHV has evolved a mechanism for acetylation-dependent protein interaction underscores the physiological importance of this cellular regulatory posttranslational modification. Furthermore, opportunity may exist to develop inhibitors that disrupt LANA acidic domain reader function for therapy of KSHV-associated tumors.
A study of poetics in Coleman Barks’ translations of Rumi
Authors: Sharifi Ahmad , Hashemi Mohammad Reza 
Published: August 2020

Abstract
Coleman Barks’ translations of Rumi’s works are astonishingly popular, especially among the American public. The study
presented here deals particularly with the role of poetics in shaping the image and reception of Rumi’s works in the target language and
culture. Thus, it describes and analyses Barks’ approach/strategies in rendering the poetic elements of Rumi’s poems, and examines Barks’
translation poetics in the context of the dominant poetics in the target literature. The corpus of the study is delimited to Barks’
renditions of the poems of the first book of the Masnavi included in The Essential Rumi (1995). The findings involve Barks’ modifications in
favor of the formal and structural conventions of English poetry, the linguistic and literary norms of the target language and the taste and
communicative needs of the target audience as well as the conformity of Barks’ translation poetics with the dominant poetics and ideology of
his time.
Lin Shu as a translator
Authors: Dai Yun-fang 
Published: August 2020

Abstract
As a pioneer of Chinese translation, Lin Shu groped for a way out of the dichotomy to achieve a balance between
foreignization and domestication. His domesticating strategies have enjoyed considerable attention from critics, whereas his
foreignization has so far been largely ignored. Mainly concentrating on his collaborative translation, Yinbian
yanyu, this essay opens a window to see Lin’s translation strategy as an inevitable mixture of domestication and
foreignization, and throws light on the contradictory nature of Lin, identifying him as both a defender and an opponent of
Confucian ideology, and as both an inheritor and an innovator of Chinese literary and linguistic traditions.
The political economy of disability in South Africa, between social grants and job-creation programmes
Authors: Schnitzler Marie 
Published: August 2020

ABSTRACTWhile previous studies focusing on disability in South Africa have mostly discussed the programme of disability grants, this article examines the interface between disability, social welfare and the labour market in the post-apartheid society. On this basis, it shows how the pressure on people with disabilities to work is framed in a progressive recognition of their right to work and agency. However, ethnographical study cases reveal the extent to which the experience of work faced every day by people with physical disabilities in a Coloured township remains disempowering and frustrating. Based on these observations, the conclusion suggests that the current system of disability grants and job creation programmes keeps many people with disabilities in a liminal situation, since the state considers them fit and unfit for work at the same time, claiming to reintegrate them into the workforce while failing to offer them long-term employment.
MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-κB signaling by targeting TLR8 in PC12 cells
Authors: Lu Ying-Yun , Ma Xiao-Jun , Yang Yan-Na 
Published: August 2020

Abstract
This work aimed to assess the role of TLR8 in cerebral I/R injury and its in-depth pathogenesis. Bioinformatics analysis indicated that TLR8 was up-regulated in patients with ischemic stroke than that in healthy control, and miR-18a-5p was the upstream regulatory of TLR8. Then, the rat pheochromocytoma PC12 cells were exposed in oxygen-glucose-deprivation/reoxygenation (OGD/R) conditions to construct a model in vitro. The functional experiments indicated that OGD/R can decline the viability and elevate the apoptosis of PC12 cells, while up-regulation of miR-18a-5p can alleviate OGD/R-induced cell injury. Notably, overexpression of TLR8 reverses the miR-18a-5p-mediated protection on OGD/R-induced cells injury. Finally, we found that up-regulation of miR-18a-5p obviously declined the protein levels of TLR4 and TLR7 as well as the phosphorylation of NF-κB, while overexpression of TLR8 canceled the decrease caused by miR-18a-5p up-regulation. In summing, our results illustrated that miR-18a-5p/TLR8 axis can mitigate OGD/R-induced cells injury through TLRs and NF-κB pathway.
The effect of calcium co‐ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study
Authors: Narang Ben J. , Wallis Gareth A. , Gonzalez Javier T. 
Published: August 2020

AbstractThe benefits of high exogenous glucose availability for endurance exercise performance are well‐established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co‐ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min−1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole‐body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min−1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min−1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men.
Climate implications of electrification projects in the developing world: a systematic review
Authors: Jeuland Marc , Ohlendorf Nils , Saparapa Rajah , Steckel Jan Christoph 
Published: August 2020

Abstract
Energy is crucial to household health and consumption needs, and for enabling productive uses that enhance development. Yet increasing energy use also affects climate change. While ‘off-grid’ renewable solutions offer the possibility of climate-sensitive development, some argue that a low emissions energy pathway conflicts with economic development. This systematic review analyzes the state of knowledge concerning the surprisingly understudied nexus of climate and development implications of electrification projects in low- and middle-income countries, focusing on whether and how these two potentially conflicting objectives can be balanced. After systematically identifying and coding the relevant literature, we describe the relationships between generation technologies, energy services, emissions, and development outcomes therein. Despite the increasing importance of this topic, relevant literature is scant, and largely supports the idea that the development impacts from off-grid, low-emissions renewables have been muted in the past, relative to high-emissions grid-based electrification. Our results hint at the fact that more sustainable long term development will inevitably require supporting poor countries in their efforts to develop high-quality electricity grids that are more reliant on low carbon technologies.
New decisions in the organization of the procedure for setting norms in standards on the example of metal products
Authors: Polyakova Marina , Dryagun Eduard 
Published: August 2020

Abstract
Standard contains the full set of requirements to the product, its production, control and acceptance. A customer and a manufacturer assess one and the same object of standardization in different ways. The function-target analysis makes it possible to find out the relation between the customer functions and the object properties. Application of this developed method results in a network graph reflecting the connections between the main useful function and individual functions as well as the properties providing these functions. The developed approach of assessment of similarity of the customer and the manufacturer positions in the process of development of standard technical requirements is based on the mathematical description of an S-curve. The proposed method makes it possible to take into account the peculiarities for setting norms in standards of metal products.
Wear of a high pressure layered pipe by a rough rigid bush
Authors: Kazakov K E , Kurdina S P 
Published: August 2020

Abstract
The article describes the solution to the problem of linear wear of a high pressure elastic pipe with an elastic coating by rigid bush worn on the pipe so that there is no gap between them. It is assumed that both the thickness of the coating in undeformed state and the shape of the inner surface of the bush are variable and depend on the coordinate along the axis of pipe. In the case when indicated characteristics are described by complex rapidly changing functions, standard approaches to solving such a problem turn out to be ineffective. The article describes an approach based on the use of special representations and basic functions that take into account the presence of complex characteristics. In the expression for contact pressures, which is the result of solving the problem and allows us to further evaluate the resource and durability of such a connection, the functions that describe the surfaces shapes are highlighted in explicit form. This allows us to perform exact calculations in cases where the forms are described by complex functions.
Time-series classification for industrial applications: a brake pad wear prediction use case
Authors: Burnaev Evgeny 
Published: August 2020

Abstract
Brake system is an important part for control of a vehicle. Hence condition monitoring of brake pads is essential for ensuring passenger’s safety. Many existing methods for brake pads wear assessment rely on specific sensors installed in the brake system, which could be expensive. Instead we use data from existing vehicle’s sensors and electronic control unit that are readily available in modern vehicles. We reduced the prediction problem to time-series classification problem and developed and tested several classification pipelines based on machine learning. We demonstrated that it is possible to predict a brake pad wear with an accuracy sufficient for real-life usage.
The “Ick” Factor: An Unrecognized Affective Predictor of Physical Symptoms During Chemotherapy
Authors: Dev Vinayak , Consedine Nathan S , Reynolds Lisa M 
Published: August 2020

Abstract

Background
Patients undergoing chemotherapy experience a range of aversive symptoms. These symptoms vary across individuals and at least some of this variation can be predicted by psychological factors, such as distress. However, while psychological distress predicts some of the symptoms, it is limited in important ways.

Purpose
To (a) assess the viability of disgust—a discrete emotion that specifically evolved for health-related reasons—as a predictor of chemotherapy-related symptoms (particularly, taste- and smell-related changes) and (b) compare the predictive utility of disgust sensitivity and propensity against the most commonly used affective predictor, that is, psychological distress.

Methods
Patients with cancer (N = 63) about to initiate chemotherapy were recruited in a prospective observational study. Psychosocial predictor variables were assessed at baseline, and outcomes (i.e., physical symptoms, body mass index [BMI], and food-based sensory-processing changes) were assessed at both baseline and 6 week follow-up.

Results
Psychological distress did not predict any of the outcomes. Both disgust sensitivity (β = .53, p = .003) and propensity (β = −.56, p = .002) predicted greater food-based sensory-processing changes, while disgust sensitivity marginally predicted greater chemotherapy-related physical symptoms (β = .34, p = .060); neither of these two forms of disgust predicted BMI.

Conclusions
The study provides first evidence showing (a) associations between trait disgust and food sensory-processing changes that arise during chemotherapy and (b) disgust as being a more useful predictor of food- and digestion-related symptoms than psychological distress. In doing so, it opens new doors for better care to be provided to patients undergoing chemotherapy.