bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile App for Mental Health Monitoring and Clinical Outreach in Veterans: Mixed Methods Feasibility and Acceptability Study
Authors: Betthauser Lisa M , Stearns-Yoder Kelly A , McGarity Suzanne , Smith Victoria , Place Skyler , Brenner Lisa A 
Published: May 2020

BackgroundAdvances in mobile health (mHealth) technology have made it possible for patients and health care providers to monitor and track behavioral health symptoms in real time. Ideally, mHealth apps include both passive and interactive monitoring and demonstrate high levels of patient engagement. Digital phenotyping, the measurement of individual technology usage, provides insight into individual behaviors associated with mental health.ObjectiveResearchers at a Veterans Affairs Medical Center and Cogito Corporation sought to explore the feasibility and acceptability of an mHealth app, the Cogito Companion.MethodsA mixed methodological approach was used to investigate the feasibility and acceptability of the app. Veterans completed clinical interviews and self-report measures, at baseline and at a 3-month follow-up. During the data collection period, participants were provided access to the Cogito Companion smartphone app. The mobile app gathered passive and active behavioral health indicators. Data collected (eg, vocal features and digital phenotyping of everyday social signals) are analyzed in real time. Passive data collected include location via global positioning system (GPS), phone calls, and SMS text message metadata. Four primary model scores were identified as being predictive of the presence or absence of depression or posttraumatic stress disorder (PTSD). Veterans Affairs clinicians monitored a provider dashboard and conducted clinical outreach when indicated.ResultsFindings suggest that use of the Cogito Companion app was feasible and acceptable. Veterans (n=83) were interested in and used the app; however, active use declined over time. Nonetheless, data were passively collected, and outreach occurred throughout the study period. On the Client Satisfaction Questionnaire–8, 79% (53/67) of the sample reported scores demonstrating acceptability of the app (mean 26.2, SD 4.3). Many veterans reported liking specific app features (day-to-day monitoring) and the sense of connection they felt with the study clinicians who conducted outreach. Only a small percentage (4/67, 6%) reported concerns regarding personal privacy.ConclusionsFeasibility and acceptability of the Cogito Corporation platform to monitor mental health symptoms, behaviors, and facilitate follow-up in a sample of veterans were supported. Clinically, platforms such as the Cogito Companion system may serve as useful methods to promote monitoring, thereby facilitating early identification of risk and mitigating negative psychiatric outcomes, such as suicide.
Evaluation Criteria for Weight Management Apps: Validation Using a Modified Delphi Process
Authors: Robles Noemí , Puigdomènech Puig Elisa , Gómez-Calderón Corpus , Saigí-Rubió Francesc , Cuatrecasas Cambra Guillem , Zamora Alberto , Moharra Montse , Paluzié Guillermo , Balfegó Mariona , Carrion Carme 
Published: May 2020

Background
The use of apps for weight management has increased over recent years; however, there is a lack of evidence regarding the efficacy and safety of these apps. The EVALAPPS project will develop and validate an assessment instrument to specifically assess the safety and efficacy of weight management apps.

Objective
The aim of this study was to reach a consensus among stakeholders on a comprehensive set of criteria to guide development of the EVALAPPS assessment instrument. A modified Delphi process was used in order to verify the robustness of the criteria that had been identified through a literature review and to prioritize a set of the identified criteria.

Methods
Stakeholders (n=31) were invited to participate in a 2-round Delphi process with 114 initial criteria that had been identified from the literature. In round 1, participants rated criteria according to relevance on a scale from 0 (“I suggest this criterion is excluded”) to 5 (“This criterion is extremely relevant”). A criterion was accepted if the median rating was 4 or higher and if the relative intraquartile range was equal to 0.67 or lower. In round 2, participants were asked about criteria that had been discarded in round 1. A prioritization strategy was used to identify crucial criteria according to (1) the importance attributed by participants (criteria with a mean rating of 4.00 or higher), (2) the level of consensus (criteria with a score of 4 or 5 by at least 80% of the participants).

Results
The response rate was 83.9% (26/31) in round 1 and 90.3% (28/31) in round 2. A total of 107 out of 114 criteria (93.9%) were accepted by consensus—105 criteria in round 1 and 2 criteria in round 2. After prioritization, 53 criteria were deemed crucial. These related mainly to the dimensions of security and privacy (13/53, 24.5%) and usability (9/53, 17.0%), followed by activity data (5/53, 9.4%), clinical effectiveness (5/53, 9.4%), and reliability (5/53, 9.4%).

Conclusions
Results confirmed the robustness of the criteria that were identified, with those relating to security and privacy being deemed most relevant by stakeholders. Additionally, a specific set of criteria based on health indicators (activity data, physical state data, and personal data) was also prioritized.
The Current State of Research, Challenges, and Future Research Directions of Blockchain Technology in Patient Care: Systematic Review
Authors: Durneva Polina , Cousins Karlene , Chen Min 
Published: May 2020

Background
Blockchain offers a promising new distributed technology to address the challenges of data standardization, system interoperability, security, privacy, and accessibility of medical records.

Objective
The purpose of this review is to assess the research on the use of blockchain technology for patient care and the associated challenges and to provide a research agenda for future research.

Methods
This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We queried the Cumulative Index of Nursing and Allied Health Literature (CINAHL), PubMed, Excerpta Medica dataBASE (EMBASE), and Web of Science databases for peer-reviewed research articles published up to December 2019 that examined the implementation of blockchain technology in health care settings. We identified 800 articles from which we selected 70 empirical research articles for a detailed review.

Results
Blockchain-based patient care applications include medical information systems, personal health records, mobile health and telemedicine, data preservation systems and social networks, health information exchanges and remote monitoring systems, and medical research systems. These blockchain-based health care applications may improve patient engagement and empowerment, improve health care provider access to information, and enhance the use of health care information for medical research.

Conclusions
Blockchain health information technology (HIT) provides benefits such as ensuring data privacy and security of health data, facilitating interoperability of heterogeneous HIT systems, and improving the quality of health care outcomes. However, barriers to using blockchain technology to build HIT include security and privacy vulnerabilities, user resistance, high computing power requirements and implementation costs, inefficient consensus algorithms, and challenges of integrating blockchain with existing HIT. With 51% of the research focused on medical information systems such as electronic health record and electronic medical record, and 53% of the research focused on data security and privacy issues, this review shows that HIT research is primarily focused on the use of blockchain technologies to address the current challenges HIT faces. Although Blockchain presents significant potential for disrupting health care, most ideas are in their infancy.
IN VITRO SHOOT REGENERATION OF SWALLOW ROOT (DECALEPIS HAMILTONII) – A STENO-ENDEMIC RED LISTED MEDICINAL PLANT
Authors: Ranganatha Manjula , AS Annapurna , Sharma Ashwani , N Rao Nagashree 
Published: May 2020

Objective: In vitro shoot regeneration of Decalepis hamiltonii Wight and Arn. is an endangered endemic medicinal plant using biotechnological interventions and to conserve this threatened species.
Methods: In the present study, various explants such as shoot tip, leaf, and nodal segments were inoculated on Murashige and Skoog media augmented with different hormonal regimes of auxin and cytokinin combinations, namely, naphthalene acetic acid (NAA), indole-3-acetic acid (IAA), benzyl adenine (BAP), 6-(γ,γ-Dimethylallylamino)purine (2iP), and triacontanol (TRIA).
Results: Direct regeneration of shoots obtained in 3.0 mg/l 2iP alone and in combination with 0.1 mg/l IAA and/or 1.0 mg/l BAP exhibited the best response with average shootlet length being 6.5±0.17–8.0±0.92 cm, respectively, and percentage response was between 68% and 75%. The callus induced regeneration was obtained from both nodal and leaf explants with maximum response (85%) observed in combination of (2.0 mg/l) 2iP, (1.0 mg/l) IAA and (2.0 mg/l) kinetin with multiple shoots showing mean shoot number of 1.83 and average shootlet length of 6.3±0.19 cm.
Conclusions: The current research provides a competent in vitro propagation method for Decalepis which could be commercialized for developing identical plants with good mass multiplication rate and for better conservation of the germplasm.
IN VITRO ANTIOXIDANT ACTIVITY AND FOURIER TRANSFORM INFRARED ANALYSIS OF ELAEAGNUS CONFERTA ROXB. LEAF EXTRACT
Authors: LALITHA G  , TH NAZEEMA 
Published: May 2020

Objective: The objective of this study was to carry out the antioxidant potential of Elaeagnus conferta (EC) Roxb. leaves that were worked on various assay 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization, total reducing power was studied by ferric reducing antioxidant power (FRAP) and total radical trapping antioxidant potential (TRAP) method. The spectroscopic technique Fourier transform infrared (FTIR) spectrophotometer was performed to detect the characteristic peak values and their functional groups of EC Roxb.
Methods: Ethanol solvent is used ABTS, DPPH, FRAP, TRAP, and FTIR analysis.
Results: ABTS assay, IC50 value was found to be 60 μg/ml compared with standard ascorbic acid 64 μg/ml. DPPH IC50 value of EC Roxb. compared with standard ascorbic acid was found to be 0.43 μg/ml and 0.62 μg/ml. FRAP IC50 value along with standard ascorbic acid was found to be 0.582 μg/ml and 0.596 μg/ml. The IC50 value of TRAP along with standard ascorbic acid was found to be 0.39 μg/ml and 0.62 μg/ml. In FTIR spectroscopic study, it revealed different characteristic peak values with various functional compounds such as phenols, alcohols, amide, alkanes, carboxylic acids, alkenes, primary amines, aromatics, ester, alkyl halides, and aliphatic amines compounds.
Conclusion: EC Roxb. leaves have a potent rich source of antioxidant. In FTIR analysis, it is confirmed with the presence of phenolic compounds that can be emphasized for efficacy in pharmaceutics.
EVALUATION OF SERUM INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA LEVELS IN PATIENTS WITH DENGUE FEVER – A TERTIARY CARE HOSPITAL BASED STUDY
Authors: DUBBAL ROHIN , BS SRIRAM 
Published: May 2020

Objective: The objective of the study was to evaluate the levels of serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) during the course of 3rd and 5th days of dengue infection.
Methods: The prospective cohort study was taken up involving 50 adults diagnosed with dengue fever and admitted to Mysore Medical College and Research Institute from December 2015 to November 2016. Detailed history has been taken and clinical examination was carried out. Venous blood sample was collected and serum separated out for estimation of IL-6 and TNF-α levels using ELISA.
Results: It has been observed that the levels of IL-6 and TNF-α raised during 3rd day of infection and there is decrease in levels of IL-6 and no changes have been observed in TNF-α levels during 5th day.
Conclusion: The study concludes that the IL-6 and TNF-α plays a key role in understanding pathogenesis of severity of dengue infection, TNF-α being more sensitive in reaction to pathogen
DEVELOPMENT AND VALIDATION OF RAPID STABILITY-INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF LINAGLIPTIN AND EMPAGLIFLOZIN IN PURE AND DOSAGE FORMS
Authors: EL SHEIKH RAGAA , S HASSAN WAFAA , YOUSSEF EMANH , Y HAMDI ABDULRAHMAN , AHMED BADAHDAH NAIF , ESA ALZUHIRI MUNEER , ELFETOUH GOUDA AYMAN ABOU 
Published: May 2020

Objective: A new, simple, rapid, sensitive, and accurate stability-indicating high-performance liquid chromatography (HPLC) method was developed and validated for the quantitative determination of linagliptin (LNG) and empagliflozin (EMP) in pure and tablet dosage forms.
Methods: An isocratic HPLC method, using a C18 reversed-phase column (150 mm×4.6 mm i.d., particle size 5 μm) with an isocratic binary mobile phase consisting of phosphate buffer and acetonitrile (65:35, v/v), was investigated to separate the drug from its stress degradation products. The flow rate was 1.0 mL/min at ambient temperature and photodiode array detector is used at 226 nm for detection. The developed method was validated for system suitability, linearity, accuracy, precision, limits of detection and quantitation, specificity, stability, and robustness.
Results: The retention time of LNG and EMP was found to be 3.276±0.002 and 6.966±0.0006 min, respectively. The calibration curve was found to be linear with the equation y=158926.39X+11.139, with a correlation coefficient of R2=0.9991 for LNG and y=22688.45X+4.259, with a correlation coefficient of R2=0.9994 for EMP over a concentration range of 2.5–7.5 μg/mL and 5.0–15 μg/mL for LNG and EMP, respectively. The limits of detection were 0.29 and 0.48 μg/mL for LNG and EMP, respectively, and the limits of quantification were 0.89 and 1.5 μg/mL for LNG and EMP, respectively. The recovery values of this method are 101.11% and 101.48% for LNG and EMP, respectively, and the reproducibility is within 0.070 and 0.277 for LNG and EMP, respectively.
Conclusion: The proposed method is a rapid stability-indicating HPLC method that can be applied for the determination of LNG and EMP in pure and tablet dosage forms.
Sanksi Pidana Terhadap Pelaku Tindak Pidana Penambangan Batu Padas Atau Paras Secara Ilegal Criminal Sanctions Against Perpetrators Of Illegal Padas (Paras Stone)
Authors: Sarasvati Audia Priti , Sepud I Made , Sutama I Nyoman 
Published: May 2020

Abstract-This study uses a type of normative legal research. The sources of legal material used are primary legal material and secondary legal material. The problem in this thesis is the regulation of criminal sanctions against the perpetrators of criminal acts of illegal rock mining (paras) and the consideration of judges against the perpetrators of criminal acts of illegal mining (paras). The results of the study can be concluded that the forms of mining business permit arrangements are regulated in Law No. 4 of 2009 concerning mining of minerals and coal. And if you want to have a permit in mining activities, you must fulfill the requirements in the form of administrative requirements, technical requirements, environmental requirements, and financial requirements. Judge's consideration in illegally imposing criminal offenses in the case number 32/Pid.sus/2017/Pn.Gin. The judge sentenced the defendant to a suspended sentence, also saw the judge's consideration of seeing the position of the case, the attitude of the defendant in the trial and returning to the conviction of the judge of the sentence whether it was appropriate to be dropped on the defendant.
Keywords: Crime, sansction, illegal paras

Abstrak-Penelitian ini dimuat untuk mengetahui pengaturan sanksi pidana terhadap pelaku tindak pidana penambangan batu padas (paras) secara ilegal di Pengadilan Negeri Gianyar, dimana dalam pengkajiannya membahas pengaturan sanksi pidana mengenai kegiatan pertambangan yang tidak mematuhi prosedur atau peraturan tanpa adanya izin dalam kasus pidana putusan pengadilan negeri No.32/Pid.Sus/2017/PN.Gin. Penelitian ini menggunakan tipe penelitian hukum normatif. Sumber bahan hukum yang digunakan adalah bahan hukum primer dan bahan hukum sekunder. Permasalahan dalam penelitian ini adalah pengaturan sanksi pidana terhadap pelaku tindak pidana penambangan batu padas (paras) secara ilegal dan pertimbangan hakim terhadap pelaku tindak pidana penambangan batu padas (paras) secara ilegal. Hasil pengkajian ini disimpulkan bahwa bentuk-bentuk pengaturan izin usaha pertambangan diatur dalam undang-undang no. 4 tahun 2009 tentang pertambangan mineral dan batubara dan jika ingin memiliki izin dalam kegiatan pertambangan harus memenuhi syarat-syarat berupa syarat administratif, syarat teknis, syarat lingkungan dan syarat finansial. Pertimbangan hakim dalam menjatuhkan pidana terhadap pelaku penambangan batu padas (paras) secara ilegal dalam kasus No. 32/Pid.Sus/2017/PN.Gin. Dilihat dari pertimbangan Hakim yakni pada posisi kasusnya, sikap terdakwa pada saat persidangan dan pada keyakinan hakim untuk memutuskan suatu hukuman yang pantas dijatuhkan kepada terdakwa. Hal tersebutlah yang mendasari Hakim untuk menjatuhkan hukuman percobaan terhadap terdakwa.
Kata kunci: Pidana, sanksi, paras illegal
Penerapan Pasal 1320 Kuh Perdata Terhadap Tanggung Jawab Penjual Dalam Perjanjian Jual Beli Barang Melalui Media Internet
Authors: Putra I Komang Mahesa , Mahendrawati Ni Luh , Arini Desak Gde Dwi 
Published: May 2020

Abstract-This trade activity by utilizing internet media is known as electronic commerce, or abbreviated as e-commerce. Regarding the relevance of existing legislation with the need for regulations in buying and selling transactions through internet media, especially the seller's responsibility. The formulation of the problem in this writing is how the legal protection for the parties in the sale and purchase agreement through the internet media and how the seller's responsibility in the sale and purchase agreement based on article 1320 of the Civil Code. The author uses the type of normative legal research and the problem approach used is the basis of the conceptual approach and legislation. The agreement needed to give birth to an agreement mandated in Article 1320 of the Civil Code is considered to have been reached if the statement of one party was received by the other party. In summary, an agreement is considered to have taken place when one of the parties agreed. The government should provide more stringent supervision for the parties who carry out this electronic transaction, namely by conducting a registration of all activities involving public interest in electronic traffic.
Keywords: Sale and Purchase Agreement, Seller responsibilities, e-commerce

Abstrak-Kegiatan yang menggunakan elektronik komersil sudah digandrungi beberapa orang dengan penggunaan yang semakin meningkat dengan pesat setiap tahunnya atau disingkat e-commerce. Berkaitan dengan relevansi peraturan perundang–undangan yang sudah ada dengan kebutuhan akan peraturan dalam transaksi jual beli melalui media internet terutama pertanggungjawaban penjual. Rumusan masalah dalam penulisan ini adalah bagaimana perlindungan hukum bagi para pihak dalam perjanjian jual beli melalui media internet dan Bagaimana tanggung jawab penjual dalam perjanjian jual beli barang berdasarkan pasal 1320 KUH Perdata. Penulis menggunakan tipe penelitian hukum normative dan pendekatan masalah yang digunakan adalah dasar pendekatan konseptual dan Peraturan perundang-undangan. Persetujuan antara kedua orang yang menjalin suatu hubungan keperdataan di anggap telah sah apabila keduanya setuju. Ringkasnya, suatu perjanjian dianggap telah terjadi pada saat salah satu pihak menyatakan sepakat. Pemerintah seyogyanya memberikan pengawasan yang lebih ketat lagi bagi para pihak yang melakukan transaksi elektronik ini yaitu dengan jalan melakukan suatu pendaftaran terhadap segala kegiatan yang menyangkut kepentingan umum didalam lalu lintas elektronik.
Kata Kunci: Perjanjian jual beli, tanggung jawab penjual, e-commerce
FATORES ASSOCIADOS A ACIDENTES DE TRABALHO ENTRE PROFISSIONAIS MOTOTAXISTAS
Authors: Santos Loiamara Barreto , Mendes Jéssica Meira , Amorim Camila Rego , Vilela Alba Benemérita Alves , Nery Adriana Alves 
Published: May 2020

O número de acidentes de trânsito envolvendo motocicleta é cada vez maior, o que expõe o profissional mototaxista à ocorrência de acidentes de trabalho. O presente estudo tem como objetivo estimar a incidência anual de acidentes de trabalho entre profissionais mototaxistas e os fatores associados a estes agravos segundo características sociodemográficas, características profissionais, condições de trabalho e presença de sintomas osteomusculares. Trata-se de estudo transversal de caráter analítico com amostra composta por 123 mototaxistas cadastrados na Associação de Mototaxistas de Jequié (taxa de resposta 77,8%). Para análise estatística, foi utilizada a técnica de regressão logística, com cálculo das razões de incidência, intervalo de confiança (95%) e nível de significância p ≤ 0,05. A incidência anual de acidentes de trabalho entre mototaxistas foi de 26,8%. Foi observada, ainda, uma incidência expressiva de acidentes entre aqueles que relataram possuir outra atividade remunerada além do serviço de mototáxi (86,7%), com associação estatisticamente significante (p = 0,03). O desempenho de duas profissões parece predispor o mototaxista a maior ocorrência de acidentes com o veículo, sendo considerado um importante problema de saúde pública.
Palavras-chave: Epidemiologia. Mototaxistas. Saúde do trabalhador. Condições de trabalho. Acidentes de trabalho.
PERCEPÇÃO DOS USUÁRIOS SOBRE SUAS NECESSIDADES DE SAÚDE NO ÂMBITO DA ATENÇÃO PRIMÁRIA NO SISTEMA ÚNICO DE SAÚDE
Authors: Fequis Taynana Soares Oliveira , Barbosa Eliana Sabrina de Souza , Lago Rozilaine Redi , Torres Lydhia Rubhia de Lima 
Published: May 2020

A atenção primária à saúde (APS) constitui espaço privilegiado de atuação de políticas públicas de saúde e representa o nível de atenção preferencial para os usuários do Sistema Único de Saúde (SUS) obterem o atendimento de suas necessidades. Diante da carência de melhor compreensão sobre este tema, buscou-se analisar a produção científica acerca da percepção dos usuários sobre suas necessidades no âmbito da APS no SUS, a partir da taxonomia de Matsumoto. Trata-se de uma revisão integrativa de literatura, na qual foram selecionados quatro artigos completos, disponíveis em língua portuguesa, como resultado da busca realizada nas bases de dados eletrônicas Lilacs e Medline, usando as palavras-chave “necessidades e demandas de serviços de saúde”, “necessidades” e “necessidades de saúde”, publicados entre 2009 e 2013. Os estudos analisados utilizam abordagem qualitativa (classificados com nível de evidência número 4), são de autoria de enfermeiros e apresentam o estado de São Paulo como local de pesquisa predominante. As categorias de necessidades de saúde expressas pelos usuários nos artigos contemplaram aquelas propostas por Matsumoto. Concluiu-se que os usuários da atenção primária do SUS compreendem suas necessidades no âmbito da APS e têm uma visão ampliada de que elas não estão atreladas apenas aos fatores biológicos, mas envolvem também a sua situação social, além do acesso que devem possuir a todos os serviços de saúde desde a porta de entrada.
Palavras-chave: Atenção primária à saúde. Necessidades e demandas de serviços de saúde.Saúde Pública.