bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukaemia
Authors: Hong Chang‐Sook , Jeong Emily , Boyiadzis Michael , Whiteside Theresa L. 
Published: August 2020

ABSTRACTMost patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by delivery of anti‐apoptotic proteins and genes conferring resistance to recipient cells. sEV levels are elevated in AML patients’ plasma at the time of diagnosis and remain elevated in complete remission after chemotherapy. The mechanism of enhanced sEV secretion in AML is unknown. We speculated that cholesterol synthesis by AML blasts may be related to elevated sEV secretion. Intracellular levels of cholesterol and of HMGCR (3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase), the rate‐limiting enzyme in cholesterol synthesizing mevalonate pathway, significantly increased in cultured AML cells or primary human non‐malignant cells treated with cytarabine or decitabine. Concomitantly, levels of sEVs produced by these cells also increased. Treatment with an HMGCR inhibitor, Simvastatin, or siRNAs targeting HMGCR blocked the chemotherapy‐induced enhancement of sEV secretion in AML cells. sEVs carry HMGCR and chemotherapy enhances HMGCR levels in sEVs. HMGCR+ sEVs upregulate intracellular cholesterol and promote AML cell proliferation. A pharmacologic blockade of HMGCR emerges as a potential future therapeutic option for disrupting sEV signalling leading to cholesterol‐driven chemo‐resistance in AML.
Quantifying the foodshed: a systematic review of urban food flow and local food self-sufficiency research
Authors: Schreiber Kerstin , Hickey Gordon M , Metson Geneviève S , Robinson Brian E , MacDonald Graham K 
Published: August 2020

Abstract
Cities are net consumers of food from local and global hinterlands. Urban foodshed analysis is a quantitative approach for examining links between urban consumers and rural agricultural production by mapping food flow networks or estimating the potential for local food self-sufficiency (LFS). However, at present, the lack of a coherent methodological framework and research agenda limits the potential to compare different cities and regions as well as to cumulate knowledge. We conduct a review of 42 peer-reviewed publications on foodsheds (identified from a subset of 829 publications) from 1979 to 2019 that quantify LFS, food supply, or food flows on the urban or regional scale. We define and characterize these studies into three main foodshed types: (1) agricultural capacity, which estimate LFS potential or local foodshed size required to meet food demands; (2) food flow, which trace food movements and embodied resources or emissions; and (3) hybrid, which combine both approaches and study dynamics between imports, exports, and LFS. LFS capacity studies are the most common type but the majority of cases we found in the literature were from cities or regions in the Global North with underrepresentation of rapidly urbanizing regions of the Global South. We use a synthetic framework with ten criteria to further classify foodshed studies, which illustrates the challenges of quantitatively comparing results across studies with different methodologies. Core research priorities from our review include the need to explore the interplay between LFS capacity and interregional food trade (both imports and exports) for foodsheds. Hybrid methodologies are particularly relevant to examining such dependency relationships in food systems by incorporating food flows into LFS capacity assessment. Foodshed analysis can inform policy related to multiple components of sustainable food systems, including navigating the social and environmental benefits and tradeoffs of sourcing food locally, regionally, and globally.
Aloe vera L. powder processing using spray drying method for coating material of agriculture products
Authors: Darmawati E , Fadhila AN 
Published: August 2020

Abstract
Alternatives that can be done to reduce the damage to agricultural products after harvest is the application of coatings. The coating produces a film on the surface of the fruit to protect the product from environmental influences that cause damage. Besides gel form, aloe vera can be processed in the form of powder, which has advantages compared to gel form. The research purpose was to study the making of aloe vera powder using a spray drying method with the treatment of drying temperature and determine the best process base on the characteristic of powder solution and form of film as a coating result. Aloe vera powder making using a spray dryer with the outlet temperature of 60 °C and 80 °C, determine the best drying temperature base on the characteristics of powder solution and film formed. Films made from aloe vera powder solution with a concentration of 10%, 15%, and 20%. The result of this research showed that the powder produced by a temperature of 60 °C was better than that done of 80 °C with the yield produced was 2.72%, and the pH value was 3.512. While for making the best film was obtained from the concentration of 20% powder solution with a viscosity value of 4.126 mPa.s, film thickness 0.321 mm, L value of films color 87.632, film water content 12%, film solubility 99%, and water vapor transmission rate 6.540 g/hour.m2.
Ingredients Formulation of Analogue Rice Based on Location Spesific Flour, Case Studies in the Purworejo District
Authors: Anggraeni DS , Solahudin M , Sutrisno  
Published: August 2020

Abstract
The determined of rice as staple food of Indonesians people will increase with increased of population growth. One of the efforts to meet basic food demand can be done through food diversification perform by using non-rice carbohydrate sources. Purworejo Regency is one of the regions that has a source of carbohydrate in addition to rice, which has not been further processed to be an alternative to meeting calorie needs other than rice. The purpose of this study is to obtain an optimal analog rice composition formulation in the form of a goal programming model by mixing non-rice base ingredients for analog rice production to produce analog rice that has nutritional characteristics determined with Ciherang rice. Conducting the results of making analog rice formulations with non-rice materials available in Purworejo District using a linear objective programming model. The linear goal programming optimization model uses a solver program with an objective function of the nutrient content of protein, amylose, and amylopectin to approach Ciherang rice. Analog rice optimization results were tested using similarity percentage values to determine the proximity of nutrient content with Ciherang rice. Based on the analysis of calculations from the solver program produces a mixture of white corn (94.674%) and taro beneng (5.326%) with a similarity of 98.381%. While the results of the optimization of the availability of carbohydrate sources in Purworejo District produced a mixture of taro beneng (19.462%), sago starch (20.668%) and breadfruit (59.851%) with the similar nutritional content of Ciherang rice of 89.717%.
Water level arrangement in the drainage channel on peat chemical characteristics, growth and corn yield
Authors: Widiarso B , Minardi S , Komariah  , Chandra T O 
Published: August 2020

Abstract
This research was aimed to study the influence of water depth in the drainage channel arrangement on peat chemical characteristics, the growth, and corn yield. This research was conducted in Rasau Jaya Umum Village, Rasau Jaya Sub-district, Kubu Raya District, West Kalimantan Province, for ten months (February - December 2016). The research field consists of three plots of land, with the area of each plot of 0.2 ha (40 m x 50 m). The depth of water drainage channels arranged in the experimental plots: treated without drainage channel, depth of water drainage channel 30 cm and depth of water drainage channel 60 cm. Pioneer 21 (P21) variety of corn was planted in the research field with the spacing of 25 cm x 75 cm and given ameliorant of coastal sediment 8 tons/ha, urea fertilizer 400 kg/ha, SP 36 300 kg/ha, and KCl 100 kg/ha. The results showed that in the soil depth of 20-40 cm, the water depth of the drainage channel 60 cm influenced the decrease of organic carbon, total N, Cation Exchange Capacity (CEC) and available P. The water level depth in the drainage channel up to 60 cm did not affect the growth and corn yield. The arrangement depth of the water level in drainage channel 30 cm is the most ideal for corn growth and sustainability of peat.
Optimation of Crawler Speeds Measurement Using Inductive Proximity for Autonomous Combine Harvester
Authors: Sutisna S P , Setiawan R P A , Subrata I D M , Mandang T 
Published: August 2020

Abstract
This paper proposes an optimal method for measuring the crawler rotational speeds of an autonomous combine harvester by the inductive proximity sensor. It mounts an inductive sensor on each wheel so it can detect the metals and the holes on the crawler drive gear. Detection of metals and holes continuously forming a cycle with a particular frequency. The crawler speed is determined by counting the number of cycles at one second as a frequency. The crawler speeds are proportional to the frequency. However, there is another way of measuring crawler speed by counting the cycle period. This research compares measuring methods for the crawler speeds using frequency and period to determine the optimal method. The results of the experiment show that measuring crawler speeds by periods is more accurate than frequency.
Design and Performance Evaluation of Dwarf Napier Grass Harvester
Authors: Desrial  , Ridha A. T. 
Published: August 2020

Abstract
Green forage is very important ingredient for animal feed either for meat cows or dairy cows. One of forage variety that now days becoming popularly used as animal feed is dwarf napier grass (Pennisetum purpureum cv Mott) because it has high productivity with short harvesting period. Cultivating dwarf napier grass is not difficult for the farmer, however harvesting this grass is quite difficult, hard work and generally still done manually by using a sickle. The purpose of this study is to design and evaluate performance of a harvesting machine for dwarf napier grass. Method of this research was common machine development method including functional and structural design analysis approaches. Performance test results showed that the machine was capable to harvest two rows of planting grass in one pass and average cutting height of 7.9 cm when using big tire and 8.6 cm when using small tire. The machine with large tire has Theoretical Field Capacity (TFC) 0.255 ha/hour, while its Effective Field Capacity (EFC) was 0.191 ha/hour and Field Efficiency (FE) was 75.01%. The result of performance test using small tire the TFC was 0.205 ha/hour, EFC was 0.145 ha/hour and FE was 71.04%. It was concluded that the newly modified napier grass harvester was satisfactorily designed and its performance increase harvesting efficiency.
Analysis of paddy productivity using normalized difference vegetation index value of sentinel-2 and UAV multispectral imagery in the rainy season
Authors: Liyantono  , Sianjaya A , Sari IK 
Published: August 2020

Abstract
Rice is one of the primary food sources for people worldwide, especially in Indonesia. In 2018, Indonesia produced approximately 56.5 million tons of unhusked dry rice ready for milling with a total area of around 10.9 million hectares. Until these days, the estimation of rice productivity was done by the Indonesia Statistics Agency (BPS) and the Ministry of Agriculture. Aerial Images and Normalized Difference Vegetation Index (NDVI) were viewed as a tool that helps in monitoring and observing the crops. NDVI was used to analyze the paddy growth from planting until harvesting. Usage of Satellite Sentinel-2 and UAV was meant to compare the accuracy between them. Analysis of paddy productivity was used during the vegetative, reproduction, and maturity phases. The used methods are regression and correlation analysis. The model from the analysis was used to estimate the productivity of paddy. The result shows that the models with the highest correlation from both Sentinel-2 and UAV were obtained from analysis on the vegetative phase. This means the implemented NDVI value was from planting until the peak value in one cultivating season.
Study of Land-use Change Monitoring in the Rawa Sei Seluang Irrigation Area and Belawang Irrigation Area, Barito Kuala Regency, South Kalimantan Province
Authors: Heryanto R Bambang 
Published: August 2020

Abstract
Food security is a basic need of each country including Indonesia, whose population is increasing rapidly is not proportional to the growth in productivity of agricultural land, especially paddy fields. Swamp Irrigation Area (DIR) which was originally designed for a rice field block area program in the early opening of transmigration land outside Java, especially in the area of Barito Kuala District, South Kalimantan Province, in fact, has now turned into rubber plantations and oil palm plantations, both managed by the community or company. The study of monitoring land-use change is very important in relation to food security programs, where the change of function or land-use changes is currently developing very rapidly in line with the level of needs and population growth. Therefore, the study of monitoring land-use change needs to be carried out as a-monitoring and also to find out in land-use change. The rice field in Sei Seluang DIR has 37.72 % from 3,297 ha the total area and rice filed in Belawang DIR have 7.45 % from 5,257 ha the total area. Satellite imagery as a monitoring tool or land-use monitoring study is very suitable because in addition to covering a fairly large area, information detail both in terms of pixel resolution and temporal resolution are now getting better in line with technological advancements, including advances in digital image processing software.
Development of knowledge management system for assisting the Agrotechno Edu-park establishments in Sriharjo village, Imogiri district, Bantul regency
Authors: Alim M F , Nugroho A P , Arif S S , Murtiningrum  , Sutiarso L 
Published: August 2020

Abstract
Knowledge is important for ensuring the sustainability of the organization. Knowledge management is an effort in obtaining, selecting, organizing, abstracting, storing, presenting, sharing, implementing, and reviewing the accumulated knowledge so that each member in an organization can utilize and increase the mastery of specific knowledge. Knowledge Management System (KMS) as a tool for assisting the implementation of the concept in a specified context. Agrotechno Edu-park stands for Agricultural Technology Education Park, a place for agricultural production, technology showroom, education, and tourism as well. In the developing and establishing the concept of Agrotechno Edu-park, there is a vast amount of knowledge, but the ability of humans to use that knowledge is limited so that the potential can be lost. Consequently, it is necessary to manage the potential knowledge using a system. The objective of this study was to develop a knowledge management system for assisting the Agrotechno Edu-park establishment. The research was taken place in Sriharjo Village, Imogiri District, Bantul Regency. Data transformation to knowledge facilitated by a web-based application composed of three main components: 1) Regular daily post, 2) Knowledge Taxonomy Trees, and 3) Discussion (Question and Answer). The knowledge management cycle runs by the participation of the youth farmer community as the operator of the Agrotechno Edu-park, facilitated by the expert from the Department of Agricultural and Biosystems Engineering, Universitas Gadjah Mada. Verification and system evaluation were conducted by GAP analysis to measure the effectivity and usability of the knowledge management system.
Quantification of leaf movement to study the circadian rhythm using the optical flow
Authors: Nugroho A P , Maghfiroh S , Fatmawati D , Edwantiar G P , Sutiarso L , Masithoh R E , Okayasu T 
Published: August 2020

Abstract
Circadian rhythm is a biological rhythm in a plant that has a 24-hour period, which affects the plant activities such as metabolism processes, physiology processes, and plant behavior. Circadian rhythm represents the biological clock that entrained by the environmental condition affected by the earth rotation. As an alternative to monitoring the circadian rhythm in the plant was the use of leaf motion as a physical indicator. The objective of this study was to present the quantitation method for leaf movement to study the circadian rhythm using the optical flow method. The leaf movement was analyzed from the captured time-lapse imaging using an Infra-red camera to capture the day-night movement of the leaf of Chili (Capsicum annum L.) from top and side view projection. As a result, the quantification method could quantify the leaf motion of Chili for both top and side view projection with the higher movement observed at top view projection. The quantified motion could show the diurnal pattern of circadian rhythm clearly and will be used for further investigation related to plant behavior in response to environmental changes.
The Influence of Information Technology on Public Transportation
Authors: Rohmawati T , Kartiwan I 
Published: August 2020

Abstract
The purpose of this study aims to find out how the satisfaction of users of public transportation to the current transportation system. The rapid development of communication technology provide social change in society, including in public transportation modes. This research used descriptive quality method in the form of literary study, where the population taken in this study are users of public transportation and users of online transportation services. The results showed that the use of information and communication technology on public transportation affects the convenience of transportation users in terms of timeliness, comfort in driving, and solutions when stuck with the ease of technology in ordering, knowing the cost route, destination location and driver identification can ensure user safety.
Location Search Application for Refuelling Stations on Android Based Mobile Devices
Authors: Nurhayati S , Milal N , Sujana A P 
Published: August 2020

Abstract
The infrastructure provided by PT Pertamina to meet fuel needs is the gas station (SPBU). Gas station infrastructure is an important infrastructure in every city. Information about the location of the gas station is necessary for motorists, especially during emergencies, namely the availability of fuel in vehicles that are running low when the user is on his way. The purpose of this study is to create a mobile device that provides gas station location information to make it easy for users to get a gas station that is close to the user’s position. The object of this research is a gas station in the city of Bandung, Indonesia. The method used to find the nearest location is Location-Based Services (LBS), a cellular service that uses user location information consisting of X and Y coordinates generated by GPS, most of which use positioning techniques. Functional analysis using Unified Modeling Language (UML). Based on testing that has been done using alpha testing, the application made already provides information about the location of the nearest gas station. Based on the results of discussions with application users, this application can help users find the closest gas station.
Web Application Vulnerability Detection Using Taint Analysis and Black-box Testing
Authors: Yulianton Heribertus , Trisetyarso Agung , Suparta Wayan , Abbas Bahtiar Saleh , Kang Chul Ho 
Published: August 2020

Abstract
Web applications continue to grow however web attacks are also increasing, this shows an increase in web application vulnerabilities. Several methods have been used to detect vulnerabilities in web applications such as black-box testing, dynamic analysis, and static analysis. In this article, we propose a framework for detecting web application vulnerabilities by combining all three methods. The strengths of one method are used to overcome the weaknesses of another method. This framework is believed to provide better results than if each method was used separately.
Sales Promotion System Design with Customer Relationship Management approach at Hotel
Authors: Mardiani G T , Faturrahman T 
Published: August 2020

Abstract
The hotel needs to consider how to establish working relationships with other companies and how to continue to increase hotel revenue. The purpose of this research is to design a system that can provide recommendations on the types of promotions given to customers based on the hotel’s sales call data, therefore the hotel’s revenue targets could be achieved. Based on the results of the analysis that has been done, which is revenue for the next periods and target of sales promotion it can be concluded that the system design is made by calculating using the Trend Linear method can determine the estimated revenue that will be achieved in the future. Therefore, the Customer Relationship Management approach can help the Director of Sales Marketing in determining the target promotion and estimation of the hotel’s revenue so that the number of customers can increase.
Private Cloud Development in West Java Cooperative and Entrepreneurship Education and Training Center
Authors: Setiyadi A , Setiawan E B 
Published: August 2020

Abstract
The purpose of this research is to build a private cloud that is used as an FTP server and database server as well as an integrated data storage medium in the education and training center of cooperatives and entrepreneurs in West Java. The stages of research from the development of private cloud in the education and training center cooperatives and entrepreneurs in West Java adopted the method of the Network Development Life Cycle (NDLC). The stages in the network development life cycle consist of six stages including the analysis phase, the design phase, the simulation stage, the implementation phase, the monitoring phase, and the regulatory stage. The results of this study are the existence and availability of server virtualization that is used to provide data-based services at the West Java Education and Cooperative Education and Entrepreneurship Training Center and the availability of integrated data storage at the West Java Education and Cooperative Education and Entrepreneurship and Training Center. The impact of this research is to be able to minimize the cost of procuring servers using private cloud using virtualization technology at the education and training center of cooperatives and entrepreneurs in West Java.
Prototype of E-Document Application Based on Digital Signatures to Support Digital Document Authentication
Authors: Afrianto I , Heryandi A , Finandhita A , Atin S 
Published: August 2020

Abstract
The purpose of this research is to develop a prototype of a web-based application that can be used to provide digital signatures on files or digital documents. This prototype uses a digital signature mechanism issued by the Ministry of Communication and Information of the Republic of Indonesia (KOMINFO). The results of the research conducted by using the alpha test showed that all functionalities in the application have been able to run well. While the authentication test shows that any changes made to a document that has a digital signature will invalidate the digital signature, which means that there are attempts to falsify documents and their authenticity can be identified. This is because in documents that have the digital signature will have a certain hash value which if the document is changed or modified, then the hash value will change. This is what determines whether a document is still original or has been modified its contents, namely by comparing the hash value contained in the document.