bluuebunny/crossref_metadata_2025_split huggingface dataset:
Search for muon-philic new light gauge boson at Belle II
Authors: Jho Yongsoo , Kwon Youngjoon , Park Seong Chan , Tseng Po-Yan 
Published: October 2019

Abstract

Motivated by the long-lasting 3.5σ discrepancy in the anomalous magnetic moment of muon, we consider a new muon-specific force mediated by a light gauge boson, X, with mass m

X
< 2m

μ
and the coupling constant gX ∼ (10−4, 10−3) . We show that the Belle II experiment has a robust chance to probe such a light boson in e
+
e
− → μ
+
μ
− + X channel and cover the most interesting parameter space explaining the discrepancy with the planned target luminosity,

$$ \int dt\ \mathcal{L}=50\ {\mathrm{ab}}^{-1} $$

∫
dt

L
=
50

ab

−
1

. The clean signal of muon-pair plus missing energy at Belle II can be a smoking gun for the new gauge boson. We expect that the (invisibly decaying) muon-philic light (m

X
≲ 2m

μ
) gauge boson can be probed down to g

X
≲ 1.5 × 10−4(4.6 × 10−4,  2.3 × 10−4) for 50 (1, 10) ab−1 search.
Mortality by diseases and medical conditions in the offspring of parents with severe mental illness
Authors: Protsenko Maria , Kerkelä M. , Miettunen J. , Auvinen J. , Järvelin M.-R. , Gissler M. , Veijola J. 
Published: October 2019

AbstractPurposeThe lifespan of people with severe mental illness (SMI) is shorter compared to the general population. There might be common familial pathway leading to a high co-occurrence of somatic disorders and SMI. To study this we explored the long-term mortality for natural causes in the offspring of people with SMI.MethodsParticipants were members of the Northern Finland Birth Cohort 1966 (NFBC1966;N = 11,325). The data on cause of deaths of the members were obtained from the Population Register Center until year 2015. The data on hospital-treated psychiatric disorders of parents were obtained from nationwide Care Register for Health Care. Cumulative incidences by age were calculated in the NFBC1966 members having a parent with SMI and those who did not have. We were able to take into account multiple confounders.ResultsOf the total sample of 11,325 offspring, 853 (7.4%) died during the follow-up period, 74 (8.7%) from the study cohort and 779 (91.3%) from the comparison group. These numbers included 160 stillborn children. There were 557 cases of deaths from diseases and medical conditions and 296 deaths from external causes. The adjusted risk ratio for offspring of mothers with SMI was 1.08 (0.72–1.64), and for offspring of fathers with SMI 0.58 (0.36–0.93).ConclusionsThis was the first long-term follow-up study (up to age 49) of all-cause mortality in offspring of parents with SMI. Our findings were contrary to expectations. Offspring of parents with SMI had no increased risk for dying. In fact, the risk for dying in the group of offspring of fathers with SMI was lower than in the comparison group. This study does not support the assumption of common familial pathway leading to a high co-occurrence of somatic disorders and SMI.
Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats
Authors: Puntscher Hannes , Aichinger Georg , Grabher Stephanie , Attakpah Eva , Krüger Franziska , Tillmann Katharina , Motschnig Tomas , Hohenbichler Julia , Braun Dominik , Plasenzotti Roberto , Pahlke Gudrun , Höger Harald , Marko Doris , Warth Benedikt 
Published: October 2019

Abstract
Despite the frequent infection of agricultural crops by Alternaria spp., their toxic secondary metabolites and potential food contaminants lack comprehensive metabolic characterization. In this study, we investigated their bioavailability, metabolism, and excretion in vivo. A complex Alternaria culture extract (50 mg/kg body weight) containing 11 known toxins and the isolated lead toxin altertoxin II (0.7 mg/kg body weight) were administered per gavage to groups of 14 Sprague Dawley rats each. After 3 h and 24 h, plasma, urine and feces were collected to determine toxin recoveries. For reliable quantitation, an LC–MS/MS method for the simultaneous detection of 20 Alternaria toxins and metabolites was developed and optimized for either biological matrix. The obtained results demonstrated efficient excretion of alternariol (AOH) and its monomethyl ether (AME) via feces (> 89%) and urine (> 2.6%) after 24 h, while the majority of tenuazonic acid was recovered in urine (20 and 87% after 3 and 24 h, respectively). Moreover, modified forms of AOH and AME were identified in urine and fecal samples confirming both, mammalian phase-I (4-hydroxy-AOH) and phase-II (sulfates) biotransformation in vivo. Despite the comparably high doses, perylene quinones were recovered only at very low levels (altertoxin I, alterperylenol, < 0.06% in urine and plasma, < 5% in feces) or not at all (highly genotoxic, epoxide-holding altertoxin II, stemphyltoxin III). Interestingly, altertoxin I was detected in all matrices of rats receiving altertoxin II and suggests enzymatic de-epoxidation in vivo. In conclusion, the present study contributes valuable information to advance our understanding of the emerging Alternaria mycotoxins and their relevance on food safety.
Increased Morbidity and Mortality of Emergency Laparotomy in Elderly Patients
Authors: Chua Melissa Sin Hui , Chan Dedrick Kok Hong 
Published: October 2019

AbstractBackgroundThere is an increasing incidence of elderly patients requiring emergency laparotomy. Our study compares the outcomes of elderly patients undergoing emergency laparotomy against the outcomes of non‐elderly patients.MethodologyPatients who underwent emergency laparotomy between 2015 and 2017 from the National University Hospital, Singapore, were included. Apart from demographic data, indication of surgery and surgical procedure performed were collected. Prospectively collected nutritional scores were evaluated. Outcome measures included duration of surgery, length of ICU and total hospital stay, post‐operative complications, and mortality indices. We performed multivariate Cox regression analysis to determine the contribution of various risk factors towards overall survival following emergency laparotomy.ResultsA total of 170 emergency laparotomies were performed. Compared to non‐elderly patients, elderly patients had a significantly longer mean stay in hospital (31.5 vs. 18.6 days, p = 0.006) and mean stay in ICU (13.1 vs. 5.3 days, p = 0.003). More elderly patients suffered from post‐laparotomy complications compared with non‐elderly patients (65.8% vs. 37.4%, p < 0.001). 30‐day mortality (31.5% vs. 8.8%, p = 0.019) and 1‐year mortality (27.9% vs. 14.3%, p = 0.023) were higher in elderly patients compared with non‐elderly patients. Interestingly, there was no statistically significant difference between elderly and non‐elderly groups in both the global 3‐MinNS as well as the global SGA nutritional scores. ASA status (HR 2.61, 95% CI 1.05–6.45, p = 0.038) was an independent risk factor for decreased survival following emergency laparotomy. Notably, while age ≥ 65 demonstrated a significant correlation with survival on univariate analysis (HR 1.03 (1.01–1.05), p = 0.003), this effect was lost following multivariate regression (HR 1.01 (0.453–2.23), p = 0.989).ConclusionElderly patients suffer worse morbidity and mortality following emergency laparotomy. This is likely contributed by comorbidities resulting in higher ASA status.
R18C is a new viable P2-like bacteriophage of rabbit origin infecting Citrobacter rodentium and Shigella sonnei strains
Authors: Sváb Domonkos , Horváth Balázs , Rohde Manfred , Maróti Gergely , Tóth István 
Published: October 2019

Abstract
Here, we report a novel virulent P2-like bacteriophage, R18C, isolated from rabbit faeces, which, in addition to Escherichia coli K-12 strains, was able to be propagated on Citrobacter rodentium strain ICC169 and a range of Shigella sonnei strains with high efficiency of plating (EOP). It represents the first lytic bacteriophage originating from rabbit and the first infectious P2-like phage of animal origin. In the three characteristic moron-containing regions of P2-like phages, R18C contains genes with unknown function that have so far only been found in cryptic P2-like prophages.
The value of a Patient Access Portal in primary care: a cross-sectional survey of 62,486 registered users in the UK
Authors: Mohammed Mohammed A. , Montague Jane , Faisal Muhammad , Lamming Laura 
Published: October 2019

Abstract
In England, primary care patients have access to Patient Access Portals (PAPs), enabling them to book appointments, request repeat medication prescriptions, send/receive messages and review their medical records. Few studies have elicited user views and value of PAPs, especially in a publicly funded primary care setting. This study aimed to elicit the value users of PAPs place on online access to medical records and linked services. Secondary data analysis of the completed electronic survey (available 2 May 2015–27 June 2015) distributed via the EMIS PAP to all its registered users. EMIS designed the survey; responses were voluntary. There were 62,486 responders (95.7% self-completed). The PAP was mainly used for medication requests (86.3%) and online appointment bookings (78.4%), and, to a lesser extent, medical record viewing (18.3%) and messaging (9.5%). The majority (70%) reported a positive impact from using it. One in five rated it as their favourite online service second only to online banking. Almost three out of four responders stated that availability of online access would influence their move to another practice. Nonetheless, responders were reluctant to award a high monetary value to it. These findings correlated with the number of long-term conditions. The majority of users place a relatively high value, but not monetary value, on the PAP and report a positive impact from using it. The potential for PAPs to enhance patient experience, especially for those with long-term conditions, appears to be largely untapped. Research exploring the reasons for non-use is also required.
Subcarrier Domain of Multicarrier Continuous-Variable Quantum Key Distribution
Authors: Gyongyosi Laszlo , Imre Sandor 
Published: October 2019

AbstractThe subcarrier domain of multicarrier continuous-variable quantum key distribution (CVQKD) is defined. In a multicarrier CVQKD scheme, the information is granulated into Gaussian subcarrier CVs and the physical Gaussian link is divided into Gaussian sub-channels. The subcarrier domain injects physical attributes to the description of the subcarrier transmission. We prove that the subcarrier domain is a natural representation of the subcarrier-level transmission in a multicarrier CVQKD scheme. We also extend the subcarrier domain to a multiple-access multicarrier CVQKD setting. We demonstrate the results through the adaptive multicarrier quadrature-division (AMQD) CVQKD scheme and the AMQD-MQA (multiuser quadrature allocation) multiple-access multicarrier scheme. The subcarrier domain representation provides a general apparatus that can be utilized for an arbitrary multicarrier CVQKD scenario.
Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies
Authors: Butowska Kamila , Kozak Witold , Zdrowowicz Magdalena , Makurat Samanta , Rychłowski Michał , Hać Aleksandra , Herman-Antosiewicz Anna , Piosik Jacek , Rak Janusz 
Published: October 2019

AbstractConjugating an anticancer drug of high biological efficacy but large cytotoxicity with a “transporting” molecule of low toxicity constitutes a valuable approach to design safe drug delivery system. In the present study, doxorubicin (DOX) a drug of large cardiotoxicity was chemically conjugated to a C60-fullerene. The synthesized molecule, a fullerene-doxorubicin conjugate (Ful-DOX), was characterized using the 1H NMR and MALDI TOF mass spectrometry. The absorption and fluorescence spectra and dynamic light scattering of the conjugate were recorded in an aqueous solution, while the impact on viability of several cancer cell lines of the free DOX and the conjugate was compared using the SRB and WST-1 assays. A low antiproliferative activity of the conjugate as compared to the free DOX is a consequence of the presence of fullerene moiety in the former, which is also responsible for the conjugate aggregation in an aqueous solution. Unlike free DOX, these aggregates cannot pass through the nuclear membrane (as demonstrated by the confocal microscopy measurements), which makes them marginally cytotoxic.
Pränataldiagnostik – klassische Analytik mittels Chorionzottenbiopsie und Amniocentese
Authors: Duba Hans-Christoph , Arzt Wolfgang 
Published: October 2019

Zusammenfassung
In diesem Artikel werden die Methoden der klassischen invasiven Pränataldiagnostik und die häufigsten, mittels konventioneller Zytogenetik diagnostizierten Chromosomenaberrationen beschrieben, um ihren, trotz der in anderen Beiträgen abgehandelten neuen Methoden, nach wie vor wichtigen Stellenwert herauszuheben.
Compatibility evaluation of modified seawater for EOR in carbonate reservoirs through the introduction of polyphosphate compound
Authors: Ghosh Bisweswar , Sun Liying , Thomas Nithin Chacko 
Published: October 2019

Abstract
Waterflood-assisted oil recovery with sulfate-spiked seawater would cause incompatibility scaling in carbonate reservoirs and reduce economic benefits. This research investigated the benefits of polyphosphate compounds in reducing scaling potential as well as its effect on oil recovery when mixed in high sulfate flood water. Severity of scaling potential of sulfate-spiked water in a carbonate reservoir environment was measured, followed by systematic screening of a polyphosphate compound, which successfully inhibited the sulfate scale precipitation at concentration as low as 100 ppm. The new formulation (seawater with four times sulfate and phosphate, SW4SP) was evaluated and compared with benchmark formulation (modified seawater with four times sulfate, SW4S). Contact angle, ζ-potential and drainage studies show that SW4SP changed the rock wettability from oil wet to water wet to a larger degree compared to SW4S. Improved recovery efficiency of SW4SP was confirmed through a set of core flooding studies in the tertiary and quaternary flood modes. Whereas SW4S recovered 7.7% of original oil in place (OOIP), SW4SP recovered about 8% of OOIP in the tertiary mode under approximately identical flow conditions. Flooding with SW4SP in the quaternary mode following a tertiary flood with SW4S on the same core resulted in 1.7% additional oil recovery, showing improved efficiency of the new flood water formulation.
Retrospective Analysis of Cancer-Associated Myositis Patients over the Past 3 Decades in a Hungarian Myositis Cohort
Authors: András Csilla , Bodoki Levente , Nagy-Vincze Melinda , Griger Zoltán , Csiki Emese , Dankó Katalin 
Published: October 2019

Abstract
Association between cancer and myositis has been extensively reported and malignancy is a potentially life-threating complication in myositis. In this retrospective study authors give an overview of Hungarian cancer-associated myositis (CAM) patients treated at a single centre managing 450 myositis patients. All patients were diagnosed according to Bohan and Peter. Statistical analysis of disease onset, age, sex, muscle, skin and extramuscular symptoms, muscle enzymes, presence of antibodies, treatment and prognosis was performed. 43 patients could be considered as having CAM. 83.72% had cancer within one year of diagnosis of myositis. Most common localizations were ductal carcinoma of breast and adenocarcinoma of lung. Significant differences were observed between CAM and the non-CAM control patients: DM:PM ratio was 2.31:1 vs. 0.87:1, respectively (p = 0.029), age at diagnosis was 56.60 ± 12.79 vs. 38.88 ± 10.88 years, respectively (p < 0.001). Tumour-treatment was the following: surgical removal in 55.81%, chemotherapy in 51.1%, radiotherapy in 39.53%, hormone treatment in 18.6%, combination therapy in 51.16% of patients. Muscle enzyme levels of patients undergoing surgery were significantly reduced after intervention. 36 patients died (83.72%); 25 DM (83.33%) and 11 PM patients (84.62%); 5 years survival was 15.4% for PM and 27.5% for DM. This study demonstrates that DM, distal muscle weakness, asymmetric Raynaud’s phenomenon, older age, ANA-negativity are risk factors for developing malignancy and polymyositis patients have less chance of long-lasting survival. It is very important to think about cancer and follow every single myositis patient in the clinical routine because survival rate of CAM is very poor.
Corrosion Behaviour of Type 316L Stainless Steel in Hot Caustic Aqueous Environments
Authors: Davalos Monteiro Raul , van de Wetering Jan , Krawczyk Benjamin , Engelberg Dirk L. 
Published: October 2019

AbstractThe corrosion behaviour of type 316L stainless steel in aqueous 30–50 wt%. NaOH at temperatures up to 90 °C has been elucidated. Exposure to room temperature environment showed parabolic weight loss behaviour, with corrosion rates of up to 0.4 mm/year. Higher NaOH concentrations and exposure temperatures resulted in a reduced stability of the electrochemical passivity domain, associated with higher corrosion rates. Exposure to de-aerated 50 wt%. NaOH presented corrosion rates of up to 0.5 mm/year at open circuit potential, with maximum corrosion rates under polarisation of up to ≈ 18 mm/year. The formation of a dark iron-oxy-hydroxide and nickel-oxide was observed, with exposure to temperatures in excess of 50 °C. The behaviour of type 316L stainless steel in hot caustic environment is compared to types 204, 304, 2205 stainless steel, and nickel alloy 200.Graphic Abstract
Short-term deflection of RC beams using a discrete rotation approach
Authors: El-Zeadani Mohamed , Rashid Raizal Saifulnaz Muhammad , Amran Mugahed Yahya Hussein , Hejazi Farzad , Jaafar Mohd Saleh 
Published: October 2019

Abstract
Quantifying the deflection of RC beams has been performed traditionally using full-interaction moment–curvature methods without considering the slip that takes place between the reinforcement and the surrounding concrete. This was commonly carried out by deriving empirically based flexural rigidities and using elastic deflection equations to predict the deformation of RC structures. However, as flexural and flexural/shear cracks form in RC beams with increase in applied load, the reinforcement steel begins to slip against the surrounding concrete surface causing the cracks to widen and ultimately increasing the deflection at mid-span. Current design rules cannot cope directly with the deformation induced by the widening of cracks. Because of that, this study focused on predicting the non-time dependent deflection of RC beams at both service and ultimate limit states using a mechanics-based discrete rotation approach. The mechanics-based solution was compared with experimental test results and well-established code methods to which a good agreement between the results was observed. The method presented accounts for the non-linear behavior of the concrete in compression, the partial-interaction behavior of the reinforcement, and the deflection was computed while considering the rotation of discrete cracks. Due to its generic nature, the method presented does not require any calibration with experimental findings on the member level, which makes it appropriate to quantify the deflection or RC structures with different types of concrete and novel reinforcement material.
Porous SiC/melamine-derived carbon foam frameworks with excellent electromagnetic wave absorbing capacity
Authors: Ye Xinli , Chen Zhaofeng , Ai Sufen , Hou Bin , Zhang Junxiong , Liang Xiaohui , Zhou Qianbo , Liu Hezhou , Cui Sheng 
Published: October 2019

Abstract
Porous three-dimensional SiC/melamine-derived carbon foam (3D-SiC/MDCF) composite with an original open pore structure was fabricated by the heat treatment of the commercial melamine foam (MF), carbonization of the stable MF, and chemical vapor deposition of the ultra-thin SiC coating. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were employed to detect the microstructure and morphology of the as-prepared composites. The results indicated that the 3D-SiC/MDCF composites with the coating structure were prepared successfully. The obtained minimum reflection loss was -29.50 dB when the frequency and absorption thickness were 11.36 GHz and 1.75 mm, respectively. Further, a novel strategy was put forward to state that the best microwave absorption property with a thin thickness of 1.65 mm was gained, where the minimum reflection loss was -24.51 dB and the frequency bandwidth was 3.08 GHz. The excellent electromagnetic wave absorption ability resulted from the specific cladding structure, which could change the raw dielectric property to acquire excellent impedance matching. This present work had a certain extend reference meaning for the potential applications of the lightweight wave absorption materials with target functionalities.
SURREAL: Subgraph Robust Representation Learning
Authors: Al-Sayouri Saba A. , Koutra Danai , Papalexakis Evangelos E. , Lam Sarah S. 
Published: October 2019

AbstractThe success of graph embeddings or nodrepresentation learning in a variety of downstream tasks, such as node classification, link prediction, and recommendation systems, has led to their popularity in recent years. Representation learning algorithms aim to preserve local and global network structure by identifying node neighborhoods. However, many existing network representation learning methods generate embeddings that are still not effective enough, or lead to unstable representations due to random processes (e.g., random walks to generate context) and thus, cannot generalize to multi-graph problems. In this paper, we propose SURREAL, a novel, stable graph embedding algorithmic framework that leverages “spatio-electric” (SE) subgraphs: it learns graph representations using the analogy of graphs with electrical circuits. It preserves both local and global connectivity patterns, and addresses the issue of high-degree nodes that may incidentally connect a pair of nodes in a graph. Further, it exploits the strength of weak ties and meta-data that have been neglected by baselines. The experiments show that SURREAL outperforms state-of-the-art techniques by up to 37% (6% on average) on different multi-label classification problems. Further, in contrast to baseline methods, SURREAL, being deterministic, is stable and thus can generalize to single and multi-graph tasks.