bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen I and collagen III polymorphisms in women with pelvic organ prolapse
Authors: Batista Nilce C. , Bortolini Maria A. T. , Silva Rebecca S. P. , Teixeira Juliana B. , Melo Natália C. , Santos Renata G. M. , Pepicelli Fernanda A. A. , Castro Rodrigo A. 
Published: July 2020

AbstractAimsVerify the presence of the single nucleotide polymorphisms rs1800012 of the collagen I (COL1A1) and rs1800255 of the collagen III (COL3A1) genes and their association with pelvic organ prolapse (POP) in Brazilian women and to determine risk factors for POP.MethodsWe assessed 826 postmenopausal women divided into POP (stages III and IV) and control groups (stages 0 and I) by examination and peripheral blood sample collection. DNA sequences of interest were analyzed by real‐time reverse‐transcriptase polymerase chain reaction. We used logistic regression analyses, recessive and codominance models of inheritance, and P < .05 for significance.ResultsSix‐hundred and thirty‐four postmenopausal women were included: 348 (54.8%) POP cases and 286 (45.1%) controls. The frequencies of GG, GA, and AA genotypes for COL1A1 were 69.12%, 20.24%, and 10.59% in POP group and 71.79%, 20%, and 8.21% in controls; GG, GT, and TT for COL3A1 were 37.54%, 59.53%, and 2.93% in POP group and 36.24%, 60.14%, and 3.62% in controls. There were no genotypic or allelic association with POP phenotype that link both SNPs rs1800012 and rs1800255 to increased risk of POP. Vaginal delivery (odds ratio [OR] = 13; 95% confidence interval [CI] [4.00‐47.08]), POP family history (OR = 3.1; 95% CI [1.49‐6.50]), diabetes mellitus (OR = 2.3; 95% CI [1.08‐5.21]), number of pregnancies (OR = 1.2; 95% CI [1.05‐1.36]), and age (OR = 1.1; 95% CI [1.09‐1.19]), were variables of increased risk for POP (P < .05 for all).ConclusionOur study suggests lack of association between DNA polymorphisms rs1800012 of COL1A1 and rs1800255 of COL3A1 with advanced POP. Vaginal delivery, POP family history, diabetes mellitus, number of pregnancies, and age are risk factors for POP.
Psychological resilience and related influencing factors in postoperative non‐small cell lung cancer patients: A cross‐sectional study
Authors: Chen Shihao , Mei Ranran , Tan Chuxia , Li Xuting , Zhong Chenxi , Ye Man 
Published: July 2020

AbstractObjectiveThe psychological resilience of postoperative non‐small cell lung cancer (NSCLC) patients is influenced by many factors. The purpose of this study is to investigate the current state of psychological resilience and identify its influencing factors in postoperative NSCLC patients.MethodsThis descriptive cross‐sectional study used a convenience sampling method and recruited 382 inpatients from two Class A hospitals in Hunan, China. The Connor‐Davidson Resilience Scale (CD‐RISC), Strategies Used by People to Promote Health (SUPHH), Medical Coping Modes Questionnaire (MCMQ), and Multidimensional Scale of Perceived Social Support (MSPSS) were used.ResultsPostoperative NSCLC patients' psychological resilience was at a low level, with a score of (57.18 ± 8.55). Stepped Linear Regression showed that the related influencing factors of psychological resilience of postoperative NSCLC patients were age (β = −0.313, P < .001), family average income (β = 0.143, P < .001), self‐efficacy (β = 0.416, P < .001), confrontation (β = 0.116, P < .001) and acceptance‐resignation (β = −0.155, P < .001), which could explain 58.0% of the total variation in psychological resilience (F = 103.68, P<.001).ConclusionsPsychological resilience is positively predicted by average income, self‐efficacy, confrontation, but negatively predicted by age and acceptance‐resignation. Self‐efficacy is the most important variable influencing psychological resilience in postoperative NSCLC patients. In the future, a series of targeted interventions need to be implemented to strengthen patients' self‐efficacy and psychological resilience, which can also improve the quality of life of postoperative NSCLC patients.
Clinical correlates of the ability to consent to research participation in brain metastasis
Authors: Gerstenecker Adam , Gammon Meredith , Marotta Dario , Fiveash John , Nabors Burt , Mulhauser Kyler , Triebel Kristen 
Published: July 2020

AbstractObjectiveImpairment in the ability to provide informed consent is common in persons with brain metastasis. However, little is known about what factors contribute to this impairment in the patient group. Our objective is to determine if the associations between demographic, cognitive, and clinical variables correlate with the ability to provide informed consent in persons with brain metastasis.MethodsWe administered a comprehensive neuropsychological battery to a group of 61 persons with brain metastasis. Demographic and clinical information was also collected. All diagnoses were made by board‐certified oncologists and were verified histologically. Statistical analyses included Pearson's product‐moment correlations, point biserial correlations, and linear regression.ResultsResults indicated that combinations of education, verbal memory, executive function, whole brain radiation therapy, and chemotherapy affected various aspects of the ability to provide informed consent. Subsequent regression models demonstrated that these variables contributed a significant amount of shared variance to the ability to provide informed consent.ConclusionWe found that the ability of persons with brain metastasis to provide informed consent is a cognitively complex ability that is also affected by education and treatment variables. This information can help clinical researchers in identifying persons with brain metastasis at risk of an impaired ability to provide informed consent and aid in the consenting process.
A three‐tier process for screening depression and anxiety among children and adolescents with cancer
Authors: Yardeni Maya , Abebe Campino Gadi , Bursztyn Shira , Shamir Anat , Mekori – Domachevsky Ehud , Toren Amos , Gothelf Doron 
Published: July 2020

AbstractObjectiveTo establish and to evaluate the effectiveness of a three‐tier screening process of depressive and anxiety disorders among children and adolescents with cancer based on questionnaires (first tier), semistructured psychiatric interviews (second tier), and referral for psychiatric assessment and recommendations for treatment (third tier). We also aimed to determine the rates of depressive and anxiety disorders among participants.MethodsParticipants and their parents completed the Patient Reported Outcomes Measurement Information System (PROMIS) Depression and Anxiety modules. Then, they were interviewed separately using the semistructured Affective and Anxiety Modules of the Schedule for Affective Disorders and Schizophrenia for School‐Age Children (K‐SADS). PROMIS cutoff values for diagnosing depressive and anxiety disorders, based on the K‐SADS, were calculated by receiver‐operating characteristics (ROCs).ResultsOf 91 participants 34 (37.4%) aged 7 to 21 years with cancer met the K‐SADS criteria for depressive and/or anxiety disorders. The results of the ROC analyses were stronger for depressive disorders than for anxiety disorders and for more severe cases. The cutoff of 13 on the child‐reported PROMIS for a major depressive episode had a sensitivity of 0.80 and a specificity of 0.82, and a cutoff of 14 on the parent‐reported PROMIS for generalized anxiety disorder had a sensitivity of 0.78 and a specificity of 0.79.ConclusionsUsing the K‐SADS, we found that anxiety and depressive disorders are very common in youngsters with cancer. The three‐tier screening process we developed for depression and anxiety in this population provides practical cutoff values for identifying depressive and anxiety disorders in children with cancer.
A model for stable isotopes of residual liquid water and ground ice in permafrost soils using arbitrary water chemistries and soil‐specific empirical residual water functions
Authors: Fisher David A. , Lacelle Denis , Pollard Wayne , Faucher Benoit 
Published: July 2020

AbstractWe present the basic theory of stable isotopes (δ(18O) and δ(D)) of freezing water solutions in the environment set within a water isotope‐augmented version of FREZCHEM(V15). We validate this model with a couple of examples. The isotope‐capable FREZCHEM is simplified to run much faster using set‐piece initial chemistries to calculate the freezing temperature of the remaining water. The fast version is embedded in a semi‐empirical model for residual liquid water in sub‐zero soils. A uniform specific soil column is driven with a defined seasonal temperature wave. The co‐isotopes of the residual water and ice are calculated as a function of time and depth. The model is applied to clayey soils of the sort sampled in detail in a 10 (10 to 20 m) core suite from the Mackenzie Delta, Canada. The stable isotopes are compared to the model ones and the match is quite good except in the uppermost 2.5 m, where an upturn in the model δ(18O) curve is smaller. If the upper 2.5 m of icy soil is populated with “modern” water, and below by late glacial meltwater the size of the upturn in δ(18O) starting at 2.5 m is reproduced by the model.
Pulmonary pneumatoceles in neonates
Authors: Rocha Gustavo 
Published: July 2020

AbstractPulmonary pneumatoceles were relatively common in neonates in the pre‐surfactant era. In the current era of surfactant, noninvasive and gentle invasive ventilation there is a paucity of data on clinical characteristics and outcomes of pneumatoceles in neonates. The lesion generally resolves spontaneously, but a few cases follow a complicated course with formation of extensive and expanding lesions. To better understand the pathophysiology, clinical significance, natural history, complications, treatment options and prognosis of pulmonary pneumatoceles in neonates, an extensive research was performed on the databases of medical literature. The information collected in this review is important for the clinicians in decision‐making, especially in the most difficult cases.
Year in review 2019: Neuromuscular diseases
Authors: Birnkrant David J. , Black Jane B. 
Published: July 2020

AbstractNeuromuscular cardiopulmonary medicine is entering a new and exciting phase, with studies that assess the respiratory effect of emerging genetic and molecular therapies. In this year's neuromuscular Year in Review, we focus on Duchenne muscular dystrophy (DMD), reviewing studies that evaluate the respiratory effect of eteplirsen, the cardiopulmonary effects of ataluren, and a study comparing the use of spironolactone with eplerenone for the treatment of DMD‐related cardiomyopathy.
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression
Authors: Nanda Jagpreet S. , Awadallah Wisam N. , Kohrt Sarah E. , Popovics Petra , Cates Justin M. M. , Mirosevich Janni , Clark Peter E. , Giannico Giovanna A. , Grabowska Magdalena M. 
Published: July 2020

AbstractBackgroundMost prostate cancers express androgen receptor (AR), and our previous studies have focused on identifying transcription factors that modify AR function. We have shown that nuclear factor I/B (NFIB) regulates AR activity in androgen‐dependent prostate cancer cells in vitro. However, the status of NFIB in prostate cancer was unknown.MethodsWe immunostained a tissue microarray including normal, hyperplastic, prostatic intraepithelial neoplasia, primary prostatic adenocarcinoma, and castration‐resistant prostate cancer tissue samples for NFIB, AR, and synaptophysin, a marker of neuroendocrine differentiation. We interrogated publically available data sets in cBioPortal to correlate NFIB expression and AR and neuroendocrine prostate cancer (NEPCa) activity scores. We analyzed prostate cancer cell lines for NFIB expression via Western blot analysis and used nuclear and cytoplasmic fractionation to assess where NFIB is localized. We performed co‐immunoprecipitation studies to determine if NFIB and AR interact.ResultsNFIB increased in the nucleus and cytoplasm of prostate cancer samples versus matched normal controls, independent of Gleason score. Similarly, cytoplasmic AR and synaptophysin increased in primary prostate cancer. We observed strong NFIB staining in primary small cell prostate cancer. The ratio of cytoplasmic‐to‐nuclear NFIB staining was predictive of earlier biochemical recurrence in prostate cancer, once adjusted for tumor margin status. Cytoplasmic AR was an independent predictor of biochemical recurrence. There was no statistically significant difference between NFIB and synaptophysin expression in primary and castration‐resistant prostate cancer, but cytoplasmic AR expression was increased in castration‐resistant samples. In primary prostate cancer, nuclear NFIB expression correlated with cytoplasmic NFIB and nuclear AR, while cytoplasmic NFIB correlated with synaptophysin, and nuclear and cytoplasmic AR. In castration‐resistant prostate cancer samples, NFIB expression correlated positively with an AR activity score, and negatively with the NEPCa score. In prostate cancer cell lines, NFIB exists in several isoforms. We observed NFIB predominantly in the nuclear fraction of prostate cancer cells with increased cytoplasmic expression seen in castration‐resistant cell lines. We observed an interaction between AR and NFIB through co‐immunoprecipitation experiments.ConclusionWe have described the expression pattern of NFIB in primary and castration‐resistant prostate cancer and its positive correlation with AR. We have also demonstrated AR interacts with NFIB.
Determining the prognostic significance of IKKα in prostate cancer
Authors: Montes Melania , MacKenzie Lewis , McAllister Milly J. , Roseweir Antonia , McCall Pamela , Hatziieremia Sophia , Underwood Mark A. , Boyd Marie , Paul Andrew , Plevin Robin , MacKay Simon P. , Edwards Joanne 
Published: July 2020

AbstractBackgroundAs the survival of castration‐resistant prostate cancer (CRPC) remains poor, and the nuclear factor‐κB (NF‐κB) pathways play key roles in prostate cancer (PC) progression, several studies have focused on inhibiting the NF‐κB pathway through generating inhibitory κB kinase subunit α (IKKα) small molecule inhibitors. However, the identification of prognostic markers able to discriminate which patients could benefit from IKKα inhibitors is urgently required. The present study investigated the prognostic value of IKKα, IKKα phosphorylated at serine 180 (p‐IKKα S180) and threonine 23 (p‐IKKα T23), and their relationship with the androgen receptor (AR) and Ki67 proliferation index to predict patient outcome.MethodsA cohort of 115 patients with hormone‐naïve PC (HNPC) and CRPC specimens available were used to assess tumor cell expression of proteins within both the cytoplasm and the nucleus by immunohistochemistry. The expression levels were dichotomized (low vs high) to determine the associations between IKKα, AR, Ki67, and patients'Isurvival. In addition, an analysis was performed to assess potential IKKα associations with clinicopathological and inflammatory features, and potential IKKα correlations with other cancer pathways essential for CRPC growth.ResultsHigh levels of cytoplasmic IKKα were associated with a higher cancer‐specific survival in HNPC patients with low AR expression (hazards ratio [HR], 0.33; 95% confidence interval [CI] log‐rank, 0.11‐0.98; P = .04). Furthermore, nuclear IKKα (HR, 2.60; 95% CI, 1.27‐5.33; P = .01) and cytoplasmic p‐IKKα S180 (HR, 2.10; 95% CI, 1.17‐3.76; P = .01) were associated with a lower time to death from recurrence in patients with CRPC. In addition, high IKKα expression was associated with high levels of T‐cells (CD3+ P = .01 and CD8+ P = .03) in HNPC; however, under castration conditions, high IKKα expression was associated with high levels of CD68+ macrophages (P = .04), higher Gleason score (P = .01) and more prostate‐specific antigen concentration (P = .03). Finally, we identified crosstalk between IKKα and members of the canonical NF‐κB pathway in the nucleus of HNPC. Otherwise, IKKα phosphorylated by noncanonical NF‐κB and Akt pathways correlated with members of the canonical NF‐κB pathway in CRPC.ConclusionThe present study reports that patients with CRPC expressing high levels of nuclear IKKα or cytoplasmic p‐IKKα S180, which associated with a lower time to death from recurrence, may benefit from IKKα inhibitors.
Ag‐Nanoparticles‐Decorated Ge‐Nanowhisker Grafted on Carbon Fiber Cloth as Flexible and Effective SERS Substrates
Authors: Liu Jing , Zhu Chuhong , Pan Qijun , Meng Guowen , Lei Yong 
Published: July 2020

AbstractThree‐dimensional (3D) flexible surface enhanced Raman scattering (SERS) substrates of silver nanoparticles (Ag‐NPs) decorated Germanium nanowhiskers (Ge‐NWHKs) grafted on carbon fiber cloth (CFC) (denoted as Ag‐NPs@Ge‐NWHKs@CFC) are constructed via chemical vapor deposition growth of high‐density Ge‐NWHKs on CFC and then assembly of Ag‐NPs on the Ge‐NWHKs by galvanic displacement. Ordered 3D framework of Ge‐NWHKs grafted flexible CFC impels the formation of large amounts of Ag‐NPs with homogenous distribution via spontaneous reduction of Ag+ ions. Thus, the Ag‐NPs@Ge‐NWHKs@CFC SERS substrates present ultra‐high sensitivity, good reproducibility, and high flexibility. This SERS sensor has achieved a detection limit of 1 pM for Rhodamine 6G and 0.1 nM for thiram respectively. The as‐fabricated SERS substrates show promising potential for applications in rapid detection of trace organic pollutants in the aquatic environment.
An Improved First‐Generation Synthesis of ent‐Oxycodone
Authors: Endoma‐Arias Mary Ann A. , Makarova Mariia , Dela Paz Helen E. , Hudlicky Tomas 
Published: July 2020

AbstractAn improvement in the stereoselective total synthesis of unnatural (+)‐oxycodone from phenethyl acetate is described. The total step count was reduced by conducting some chemical transformations in “one‐pot” and a change in the sequence of chemical operations was implemented, in comparison with the previously published first‐generation synthesis. The synthesis of (+)‐oxycodone was completed in a total of 12 operations (17 steps) and an overall yield of 1.6%, in comparison to our previous synthesis (13 operations, 19 steps, 1.5% yield) Experimental and spectral data are provided for all new compounds.
Fabrication of Fe3O4/O‐Carboxylmethyl Chitosan Magnetic Particle Assembles in Inverse Miniemulsions for Loading and Release of Bovine Serum Albumin
Authors: Gao Feng , Qi Qi , Liang Xiaoqin , Wen Lixin , Shang Yi , Mi Yifang , Ziener Ulrich , Cao Zhihai 
Published: July 2020

AbstractFe3O4/O‐carboxylmethyl chitosan (OCMC) magnetic particle assembles (MPAs) with high magnetite loading and superparamagnetism were controllably prepared through Schiff base crosslinking reaction of OCMC‐stabilized Fe3O4 magnetic nanoparticles (OCMC‐Fe3O4 MNPs) in the dispersed phase of inverse miniemulsions. The Fe3O4/OCMC MPAs were composed of many tiny Fe3O4 MNPs, and they did not only inherit the good superparamagnetism of OCMC‐Fe3O4 MNPs, but also displayed high collective magnetic response to an external magnetic field. The crosslinked network of OCMC offered a good structural integrity of the Fe3O4/OCMC MPAs either in inverse emulsions or in aqueous dispersions within a wide pH range. The Fe3O4/OCMC MPAs displayed a reversible pH‐dependent loading and release behavior of a model protein, bovine serum albumin, exhibiting a great potential in functioning as nanocarriers for loading and release of biomacromolecules.
Histidine‐Naphthalimide based Organic‐Inorganic Nanohybrid for Electrochemical Detection of Cyanide and Iodide ions
Authors: Chaudhary Monika , Verma Meenakshi , Jena Kailash C. , Singh Narinder 
Published: July 2020

AbstractHistidine‐naphthalimide based receptors were prepared with variation of the side chain amine having morpholine and 1,1‐dimethylethylenediamine. The prepared organic compounds were then employed as a framework for the fabrication of organic‐inorganic nanohybrid assembly with the aim of detection of environmentally essential anions in the aqueous medium. The size and morphology of the nanohybrid particles were confirmed with TEM and DLS analysis. Hybrid nanoparticles of morpholine naphthalimide show selective and sensitive response with cyanide ion. Subsequently, the hybrid nanoparticles of 1,1‐dimethylethylenediamine naphthalimide display visible difference with iodide ions and the response was electrochemically detected. Both the hybrid nanoparticles were utilized for the selective and sensitive detection of CN− and I− ions; with quite low detection limits.
Reactive oxygen species regulate miR‐17‐5p expression via DNA methylation in paraquat‐induced nerve cell damage
Authors: Zhan Yanting , Guo Zhenkun , Zheng Fuli , Zhang Zhipeng , Li Ke , Wang Qingqing , Wang Lijin , Cai Zhipeng , Chen Nengzhou , Wu Siying , Li Huangyuan 
Published: July 2020

AbstractThere is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR‐17‐5p expression changes in paraquat (PQ)‐induced nerve cell damage. In the present study, neuro‐2a cells were pretreated with antioxidant N‐acetylcysteine (NAC) or DNA methylation inhibitor decitabine (DAC), then exposed to different concentrations of PQ, while the expression levels of miR‐17‐5p were detected by qRT‐PCR. Here, it is showed that PQ downregulated the expression of miR‐17‐5p dose‐dependently in neuro‐2a cells. The DNA methylation level was upregulated after PQ exposure, while downregulated with the pretreatment of NAC in the above content, detected by 5‐mC immunofluorescence technique. The interaction effect of NAC and PQ in alternating DNA methylation level was further confirmed by flow cytometry. NAC and DAC individually had an interaction effect in PQ‐induced nerve cell damage. After using NAC, PQ‐induced ROS elevation and DNA methylation are reduced, thereby preventing the proapoptotic effect of miR‐17‐5p. Above all, PQ can induce DNA methylation variations through ROS production, leading to the downregulation of miR‐17‐5p expression in PQ‐induced nerve cell damage.
First‐principles dynamics of photoexcited molecules and materials towards a quantum description
Authors: You Peiwei , Chen Daqiang , Lian Chao , Zhang Cui , Meng Sheng 
Published: July 2020

AbstractThe past decades have witnessed the success of ground‐state density functional theory capturing static electronic properties of various materials. However, for time dependent processes especially those involving excited states, real‐time time‐dependent density functional theory (rt‐TDDFT) and advanced nonadiabatic algorithms are essential, especially for practical simulations of molecules and materials under the occurrence of ultrafast laser field. Here we summarize the recent progresses in developing rt‐TDDFT approaches within numerical atomic orbitals and planewave formalisms, as well as the efforts combining rt‐TDDFT and ring polymer molecular dynamics to take into account nuclear quantum effects in quantum electronic‐nuclear dynamic simulations. Typical applications of first‐principles dynamics of excited electronic states including high harmonic generation, charge density wave, photocatalytic water splitting, as well as quantum nuclear motions in ozone and graphene, are presented to demonstrate the features and advantages of these methods. The progresses in method developments and practical applications provide unprecedented insights into nonadiabatic dynamics of excited states in the Ehrenfest scheme and beyond, towards a comprehensive understanding of excited electronic structure, electron–phonon interactions, photoinduced charge transfer and chemical reactions, as well as quantum nuclear motions in excited states.This article is categorized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Electronic Structure Theory > Density Functional Theory
Molecular and Statistical Mechanics > Molecular Dynamics and Monte‐Carlo Methods