bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens
Authors: Mattio Luce M. , Dallavalle Sabrina , Musso Loana , Filardi Rossella , Franzetti Laura , Pellegrino Luisa , D’Incecco Paolo , Mora Diego , Pinto Andrea , Arioli Stefania 
Published: December 2019

AbstractPlant polyphenolic compounds are considered a promising source for new antibacterial agents. In this study, we evaluated the antimicrobial activity of a collection of resveratrol-derived monomers and dimers screened as single molecules against a panel of nine foodborne pathogens. The results demonstrated that two monomers (i.e., pterostilbene 2 and (E)-3-hydroxy-4′,5-dimethoxystilbene 9) and three dimers (i.e., δ-viniferin 10, viniferifuran 14 and dehydro-δ-viniferin 15) were endowed with significant antibacterial activity against gram-positive bacteria. The exposure of gram-positive foodborne pathogens to 100 µg/mL of 2, 9 and 15 induced severe cell membrane damage, resulting in the disruption of the phospholipid bilayer. The most promising dimeric compound, dehydro-δ-viniferin 15, was tested against Listeria monocytogenes, resulting in a loss of cultivability, viability and cell membrane potential. TEM analysis revealed grave morphological modifications on the cell membrane and leakage of intracellular content, confirming that the cell membrane was the principal biological target of the tested derivative.
Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion
Authors: Keppner Anna , Maric Darko , Sergi Chloé , Ansermet Camille , De Bellis Damien , Kratschmar Denise V. , Canonica Jérémie , Klusonova Petra , Fenton Robert A. , Odermatt Alex , Crambert Gilles , Hoogewijs David , Hummler Edith 
Published: December 2019

AbstractThe kidney needs to adapt daily to variable dietary K+ contents via various mechanisms including diuretic, acid-base and hormonal changes that are still not fully understood. In this study, we demonstrate that following a K+-deficient diet in wildtype mice, the serine protease CAP2/Tmprss4 is upregulated in connecting tubule and cortical collecting duct and also localizes to the medulla and transitional epithelium of the papilla and minor calyx. Male CAP2/Tmprss4 knockout mice display altered water handling and urine osmolality, enhanced vasopressin response leading to upregulated adenylate cyclase 6 expression and cAMP overproduction, and subsequently greater aquaporin 2 (AQP2) and Na+-K+-2Cl− cotransporter 2 (NKCC2) expression following K+-deficient diet. Urinary acidification coincides with significantly increased H+,K+-ATPase type 2 (HKA2) mRNA and protein expression, and decreased calcium and phosphate excretion. This is accompanied by increased glucocorticoid receptor (GR) protein levels and reduced 11β-hydroxysteroid dehydrogenase 2 activity in knockout mice. Strikingly, genetic nephron-specific deletion of GR leads to the mirrored phenotype of CAP2/Tmprss4 knockouts, including increased water intake and urine output, urinary alkalinisation, downregulation of HKA2, AQP2 and NKCC2. Collectively, our data unveil a novel role of the serine protease CAP2/Tmprss4 and GR on renal water handling upon dietary K+ depletion.
Magnetization switching of a perpendicular nanomagnet induced by vertical nonlocal injection of pure spin current
Authors: Suto Hirofumi , Nagasawa Tazumi , Kanao Taro , Yamada Kenichiro , Mizushima Koichi 
Published: December 2019

AbstractInjection of pure spin current using a nonlocal geometry is a promising method for controlling magnetization in spintronic devices from the viewpoints of increasing freedom in device structure and avoiding problems related to charge current. Here, we report an experimental demonstration of magnetization switching of a perpendicular magnetic nanodot induced by vertical injection of pure spin current from a spin polarizer with perpendicular magnetization. In comparison with direct spin injection, the current amplitude required for magnetization switching is of the same order and shows smaller asymmetry between parallel-to-antiparallel and antiparallel-to-parallel switching. Simulation of spin accumulation reveals that, in the case of nonlocal spin injection, the spin torque is symmetric between the parallel and antiparallel configuration because current flows through only the spin polarizer, not the magnetic nanodot. This characteristic of nonlocal spin injection is the origin of the smaller asymmetry of the switching current and can be advantageous in spintronic applications.
Association between health related quality of life and progression of chronic kidney disease
Authors: Oh Tae Ryom , Choi Hong Sang , Kim Chang Seong , Bae Eun Hui , Oh Yun Kyu , Kim Yong-Soo , Choi Kyu Hun , Kim Soo Wan , Ma Seong Kwon 
Published: December 2019

AbstractThe impact of health-related quality of life (HRQOL) on outcomes remains unclear in chronic kidney disease (CKD) patients despite its importance in socioeconomic aspects and individual health. We aim to identify the relationship between HRQOL and progression of CKD in pre-dialysis patients. A total 1622 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease, a prospective cohort study. CKD progression was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. The group with CKD progression had lower scores of HRQOL than the group without CKD progression. A fully adjusted Cox proportional hazard ratio model showed that each low baseline physical and mental component summary score was associated with a higher risk of CKD progression. In Kaplan-Meier survival analysis using propensity score matched data, only low physical component summary scores showed statistical significance with CKD progression. Our study highlights low physical component summary score for an important prognostic factor of CKD progression. Risk-modification interventions for high-risk patients may provide benefits to individuals.
Nanosized hydroxyapatite and β-tricalcium phosphate composite: Physico-chemical, cytotoxicity, morphological properties and in vivo trial
Authors: da Silva Brum Igor , de Carvalho Jorge José , da Silva Pires Jorge Luis , de Carvalho Marco Antonio Alencar , dos Santos Luiza Braga Ferreira , Elias Carlos Nelson 
Published: December 2019

AbstractThe objective of this work was to characterize the properties of a synthetic biomaterial composite with nanoparticles size (Blue Bone). This biomaterial is a composite recommended for dental and orthopedic grafting surgery, for guided bone regeneration, including maxillary sinus lift, fresh alveolus filling, and treatment of furcation lesions. The nano biomaterials surface area is from 30% to 50% higher than those with micro dimensions. Another advantage is that the alloplastic biomaterial has homogeneous properties due to the complete manufacturing control. The analyzed biomaterial composite was characterized by XRD, cytochemistry, scanning electron microscopy, porosimetry and in vivo experiments (animals). The results showed that the analyzed biomaterial composite has 78.76% hydroxyapatite [Ca5(PO4)3(OH)] with monoclinic structure, 21.03% β-tricalcium phosphate [β -Ca3(PO4)2] with trigonal structure and 0.19% of CaO with cubic structure, nanoparticles with homogeneous shapes, and nanoporosity. The in vivo experiments showed that the composite has null cytotoxicity, and the site of insertion biomaterials has a high level of vascularization and bone formation. The conclusion is that the synthetic biomaterial with Blue Bone designation presents characteristics suitable for use in grafting surgery applications.
Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome
Authors: Nozu Tsukasa , Miyagishi Saori , Nozu Rintaro , Takakusaki Kaoru , Okumura Toshikatsu 
Published: December 2019

AbstractLipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and gut hyperpermeability via corticotropin-releasing factor (CRF) and proinflammatory cytokines, which is a rat irritable bowel syndrome (IBS) model. As butyrate is known to suppress the release of proinflammatory cytokine, we hypothesized that butyrate alleviates these colonic changes in IBS models. The visceral pain was assessed by electrophysiologically measuring the threshold of abdominal muscle contractions in response to colonic distention. Colonic permeability was determined by measuring the absorbance of Evans blue in colonic tissue. Colonic instillation of sodium butyrate (SB; 0.37−2.9 mg/kg) for 3 days inhibited LPS (1 mg/kg)-induced visceral allodynia and colonic hyperpermeability dose-dependently. Additionally, the visceral changes induced by repeated WAS (1 h for 3 days) or CRF (50 µg/kg) were also blocked by SB. These effects of SB in the LPS model were eliminated by compound C, an AMPK inhibitor, or GW9662, a PPAR-γ antagonist, NG-nitro-L-arginine methyl ester, a NO synthesis inhibitor, naloxone or sulpiride. SB attenuated visceral allodynia and colonic hyperpermeability in animal IBS models. These actions may be AMPK and PPAR-γ dependent and also mediated by the NO, opioid and central dopamine D2 pathways. Butyrate may be effective for the treatment of IBS.
Introduction to the Forum on Cluttering: Rays of Hope Shine Around the World
Authors: Reichel Isabella 
Published: December 2019

Purpose
In the 10 years since the International Cluttering Association (ICA) was created, this organization has been growing in the scope of its initiatives, and in the variety of resources it makes available for people with cluttering (PWC). However, the awareness of this disorder and of the methods for its intervention remain limited in countries around the world. A celebration of the multinational and multicultural engagements of the ICA's Committee of the International Representatives is a common thread running through all the articles in this forum. The first article is a joint effort among international representatives from five continents and 15 countries, exploring various themes related to cluttering, such as awareness, research, professional preparation, intervention, and self-help groups. The second article, by Elizabeth Gosselin and David Ward, investigates attention performance in PWC. In the third article, Yvonne van Zaalen and Isabella Reichel explain how audiovisual feedback training can improve the monitoring skills of PWC, with both quantitative and qualitative benefits in cognitive, emotional, and social domains of communication. In the final article, Hilda Sønsterud examines whether the working alliance between the client and clinician may predict a successful cluttering therapy outcome.

Conclusions
Authors of this forum exchanged their expertise, creativity, and passion with the goal of solving the mystery of the disconcerting cluttering disorder with the hope that all PWC around the globe will have access to the most effective evidence-based treatments leading to blissful and successful communication.
Getting the Word “Out”: A Role for the Motor System in Autism Spectrum Disorder
Authors: Mody Maria , McDougle Christopher J. 
Published: December 2019

PurposeAutism spectrum disorder (ASD) lacks a clear neurobiological marker, and hundreds of genes appear to be implicated in the disorder. Numerous studies have reported deficits in reciprocal vocalization, vocal imitation, imitation of facial gestures, social gaze, and speech output early on in development in infants and young children at risk for or diagnosed with ASD.MethodWe examine these deficits in the context of a growing role for the motor system in communication deficits, a core feature of ASD. We draw on cognitive neuroscience and evolutionary models of speech and language to highlight the significance of a perceptuomotor link in neurodevelopmental disorders of speech and language. Interventions that target speech deficits by integrating articulatory awareness with phonetic feedback may hold tremendous promise for strengthening speech pathways in the brain and improving speech output in individuals with ASD.ConclusionThe findings call for greater interdisciplinary collaboration that harnesses clinical expertise across social, verbal, and motor domains in early treatment approaches with individuals on the autism spectrum.
Present-day mass-metallicity relation for galaxies using a new electron temperature method
Authors: Yates R. M. , Schady P. , Chen T.-W. , Schweyer T. , Wiseman P. 
Published: December 2019

Aims.We investigate electron temperature (Te) and gas-phase oxygen abundance (ZTe) measurements for galaxies in the local Universe (z <  0.25). Our sample comprises spectra from a total of 264 emission-line systems, ranging from individual HIIregions to whole galaxies, including 23 composite HIIregions from star-forming main sequence galaxies in the MaNGA survey.Methods.We utilise 130 of these systems with directly measurableTe(OII) to calibrate a new metallicity-dependentTe(OIII)–Te(OII) relation that provides a better representation of our varied dataset than existing relations from the literature. We also provide an alternativeTe(OIII)–Te(NII) calibration. This newTemethod is then used to obtain accurateZTeestimates and form the mass – metallicity relation (MZR) for a sample of 118 local galaxies.Results.We find that all theTe(OIII)–Te(OII) relations considered here systematically under-estimateZTefor low-ionisation systems by up to 0.6 dex. We determine that this is due to such systems having an intrinsically higher O+abundance than O++abundance, renderingZTeestimates based only on [OIII] lines inaccurate. We therefore provide an empirical correction based on strong emission lines to account for this bias when using our newTe(OIII)–Te(OIII) andTe(OIII)–Te(NII) relations. This allows for accurate metallicities (1σ = 0.08 dex) to be derived for any low-redshift system with an [OIII]λ4363 detection, regardless of its physical size or ionisation state. The MZR formed from our dataset is in very good agreement with those formed from direct measurements of metal recombination lines and blue supergiant absorption lines, in contrast to most otherTe-based and strong-line-based MZRs. Our newTemethod therefore provides an accurate and precise way of obtainingZTefor a large and diverse range of star-forming systems in the local Universe.
The widest Hα survey of accreting protoplanets around nearby transition disks
Authors: Zurlo A. , Cugno G. , Montesinos M. , Perez S. , Canovas H. , Casassus S. , Christiaens V. , Cieza L. , Huelamo N. 
Published: December 2019

Context. The mechanisms of planet formation are still under debate. We know little about how planets form, even if more than 4000 exoplanets have been detected to date. Recent investigations target the cot of newly born planets: the protoplanetary disk. At the first stages of their life, exoplanets still accrete material from the gas-rich disk in which they are embedded. Transitional disks are indeed disks that show peculiarities, such as gaps, spiral arms, and rings, which can be connected to the presence of substellar companions.
Aims. To investigate what is responsible for these features, we selected all the known transitional disks in the solar neighborhood (<200 pc) that are visible from the southern hemisphere. We conducted a survey of 11 transitional disks with the SPHERE instrument at the Very Large Telescope. This is the largest Hα survey that has been conducted so far to look for protoplanets. The observations were performed with the Hα filter of ZIMPOL in order to target protoplanets that are still in the accretion stage. All the selected targets are very young stars, less than 20 Myr, and show low extinction in the visible.
Methods. We reduced the ZIMPOL pupil stabilized data by applying the method of the angular spectral differential imaging (ASDI), which combines both techniques. The datacubes are composed of the Cnt_Hα and the narrow band filter Hα, which are taken simultaneously to permit the suppression of the speckle pattern. The principal component analysis method was employed for the reduction of the data. For each dataset, we derived the 5σ contrast limit and converted it in upper limits on the accretion luminosity.
Results. We do not detect any new accreting substellar companions around the targeted transition disks down to an average contrast of 12 magnitudes at 0.′′2 from the central star. We have recovered the signal of the accreting M star companion around the star HD 142527. We have detected and resolved, for the first time in visible light, the quadruple system HD 98800. For every other system, we can exclude the presence of massive actively accreting companions, assuming that the accretion is not episodic and that the extinction is negligible. The mean accretion luminosity limit is 10−6 L⊙ at a separation of 0.′′2 from the host.
Kommentar zur AWMF-S2k-Leitlinie von 2018 zur Prä-Expositions-Prophylaxe der HIV-Infektion (PrEP)
Authors: Nagel Stefan 
Published: December 2019

ZusammenfassungZusätzlich zu den bisherigen Präventionsmethoden stellt die Prä-Expositions-Prophylaxe (PrEP) eine neuartige und wirksame Vorgehensweise zur Vorbeugung einer HIV-Infektion dar. Sie ergänzt die bisherigen Methoden des Kondomgebrauchs sowie des Schutzes durch eine effektive Unterdrückung der Viruslast mittels medikamentöser Behandlung (Schutz durch Behandlung). Ziel ist, eine weitere Reduktion der Neuinfektionszahlen durch die vorbeugende Einnahme einer antiretroviralen Medikation bei bisher HIV-negativen Personen mit entsprechenden Risiken zu erreichen. Für dieses Vorgehen gibt die 2018 konsentierte AWMF-S2k-Leitlinie Empfehlungen sowohl zum Vorgehen im Vorfeld (Diagnostik, Indikation, Verschreibung, Beratung) als auch zur eigentlichen Behandlung mit dem Kombinationspräparat Emtricitabin/Tenofovirdisoproxil (TDF/FTC) als auch zum begleitenden medizinischen Monitoring im Verlauf der Behandlung bezüglich medikationsbedingter Risiken und Risiken des Auftretens anderer sexuell übertragbarer Erkrankungen.
Perspektive eines HIV-Behandlers auf die PrEP
Authors: Schellberg Sven 
Published: December 2019

ZusammenfassungSven Schellberg ist als Arzt in der Novopraxis tätig, einer HIV-Schwerpunktpraxis in Berlin. Er ist immer häufiger mit Patient_innen konfrontiert, die nach der PrEP fragen. Er würdigt die Gründe, warnt aber auch vor einer manchmal allzu unkritischen „Medikalisierung schwuler Sexualität“. Und er wünscht sich, dass offene Gespräche über sexuelles Verhalten und sexuelles Wohlbefinden, über HIV- und STI-Prävention nicht nur in HIV-Schwerpunktpraxen, sondern ganz selbstverständlich auch in anderen Arztpraxen stattfinden. Doch das scheint viel zu oft noch ein Tabu zu sein.
Testicular–Epididymal Dissociation: Vas and Vessels May “Lead up the Garden Path”
Authors: Papageorgiou Eleni , Mantovani Alberto , Monti Elena , Brain Caroline , Smeulders Naima , Cherian Abraham 
Published: December 2019

The vas deferens and spermatic vessels entering the inguinal canal through the internal inguinal ring is thought to exclude an intra-abdominal testis. We present a case of high bilateral intra-abdominal testes on a 46,XY boy despite the vas deferens and good-sized vessels passing through the deep rings.Data were collected from clinical records, radiology (ultrasound, magnetic resonance imaging [MRI]), and endocrine blood tests.This case underlines the importance of following the pathway of embryological descent of the testis cranially as well as caudally during diagnostic laparoscopy, to avoid missing this rare anatomical variant.
Evaluation of Serum Ferritin as a Prognostic Marker in Acute Hemorrhagic Stroke
Authors: Rajendran Sowri Rajan , Periyasamy Sivakumar , Manjuladevi Moonishaa Thiyagarajan , George Neethu 
Published: December 2019

AbstractBackground Acute hemorrhagic stroke (AHS) resulting from intracerebral hemorrhage (ICH) is a rampant neurological disorder with devastating consequences, particularly in Indians. Recently, serum ferritin levels have been related to adverse cardiovascular and stroke outcomes. We aimed to evaluate the prognostic utility of serum ferritin in AHS.Materials and Methods Admission serum ferritin levels were estimated in 50 AHS patients with primary supratentorial hemorrhage. Study subjects were categorized based on their prognostic scores in modified Rankin scale (mRS) assessment. Ferritin levels were compared across the study groups, correlated with mRS and other ICH severity indicators.Results Serum ferritin and other ICH severity indices such as Glasgow coma scale (GCS) and ICH volume were significantly altered in the mRS groups by the end of 7th and 30th days of hospitalization. Elevated ferritin levels, ICH volume together with decreased GCS, characterized the groups with adverse prognosis. Serum ferritin moderately correlated with GCS (r= –0.643), ICH volume (r= 0.562), and had significantly higher correlations with long-term prognostic scores of 7th day mRS (r= 0.802) and 30th day mRS (r= 0.916).Conclusion  Elevated admission serum ferritin levels indicate poor AHS short-term and long-term outcomes, thereby making serum ferritin a possible prognostic index for the same.
Successful Management of Esophageal Perforation with Self-Expandable Metal Stent following Pneumatic Dilation for Achalasia Cardia
Authors: Verma Abhai , Mohindra Samir , Saraswat Vivek Anand , Ghoshal Uday Chand 
Published: December 2019

AbstractAchalasia cardia is the most common cause of motor dysphagia. Pneumatic dilation (PD) of lower esophageal sphincter remains the cornerstone of treatment. However, it is associated with esophageal perforation in some cases. We present a case of esophageal perforation following PD of achalasia cardia which was successfully managed with esophageal stent.
Prevalence of Hearing Loss and Associated Factors in School-Age Individuals in an Urban Area of Northeast Brazil
Authors: Nunes Aryelly Dayane Silva , Balen Sheila Andreoli , Souza Dyego Leandro Bezerra , Barbosa Isabelle Ribeiro 
Published: December 2019

Abstract
Introduction Hearing loss interferes in the development of language and verbal capacities, which causes learning difficulties and deleterious effects.
Objective To analyze the prevalence and associated factors for hearing loss in school-age individuals of the municipality of Natal, state of Rio Grande do Norte, Northeast Brazil.
Methods Cross-sectional study that evaluated 238 school-age individuals (6–17 years old) in municipal public schools. Meatoscopy was performed and school-age individuals answered the questions “Do you think that you hear well?” and “Do you have earaches?”. Auditory evaluation was performed with a Telessaúde audiometer. The responsible adults answered socioeconomic, speech and audiology aspects and risk factors for hearing loss questionnaire.
Results The prevalence of hearing loss was 16% (11.7–21.4%); 16% reported not to hear well, 18.9% reported earaches, and 26.1% presented altered meatoscopy. The prevalence of hearing loss was higher in school-age individuals who reported hearing difficulties, in children between the ages of 6 and 12, and with altered meatoscopy results (p < 0.05). Airway infection (PR = 3.37; 95% confidence interval [CI]: 1.48–7.68) was found as a risk factor associated with hearing loss, remaining significant in the multivariate model (PR = 6.79; 95%CI: 1.98–23.26; p = 0.002).
Conclusions Hearing loss in this sample is above the values reported in other studies performed in Brazil for this age group. This highlights the necessity of better structure of speech and audiology attention, so that auditory health promotion actions can be systematized for this population.