bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological social capital does not predict geographical variance in increases in depression following the 2008 financial crisis
Authors: Saville Christopher W. N. 
Published: May 2020

Research suggests that the financial crisis of 2008 and its aftermath were associated with an increase in mental health problems, but there has been little research into potential protective factors. Ecological social capital is a plausible candidate given evidence of its protective status following natural disasters. Pre‐crisis area‐level estimates of generalized trust and sense of belonging were computed from the 2004 to 2006 waves of the Living in Wales survey (N = 43,473) for 413 neighbourhoods in Wales, using multilevel regression with post‐stratification, a technique for disaggregating survey data into small area estimates. Area estimates and the planned analysis were preregistered using Open Science Framework. Data (N = 180,462) from the Welsh Health Survey (2003–2015) were then used to model whether social capital was protective against depression in general and whether it moderated the increase in depression prevalence, associated with the financial crisis. Depression rates increased post‐crisis (odds ratio [OR] = 1.271), and trust was a protective factor against depression (OR = 0.775). The hypothesized interaction, however, was not significant (OR = 1.033), nor was sense of belonging (OR = 0.934) or its interaction with the crisis (OR = 1.024). Although ecological generalized trust appears to be a protective factor against depression, it did not buffer against the mental health impact of the financial crisis.
Burdens and awareness of adverse self‐reported lifestyle factors in men with sub‐fertility: A cross‐sectional study in 1149 men
Authors: Jayasena Channa N. , Sharma Aditi , Abbara Ali , Luo Rong , White Christopher J. , Hoskin Sophie G. , Khanjani Shirin , Crawford Mike J. , Ramsay Jonathan W. , Minhas Sukhbinder , Dhillo Waljit S. 
Published: May 2020

AbstractBackgroundThere are no current pharmacological therapies to improve sperm quality in men with sub‐fertility. Reducing the exposure to lifestyle risk factor (LSF) is currently the only intervention for improving sperm quality in men with sub‐fertility. No previous study has investigated what proportion of men with sub‐fertility are exposed to adverse lifestyle factors. Furthermore, it is not known to what extent men with sub‐fertility are aware of lifestyle factors potentially adversely impacting their fertility.MethodsA cross‐sectional anonymous questionnaire‐based study on self‐reported exposure and awareness of LSF was conducted in 1149 male partners of couples investigated for sub‐fertility in a tertiary andrology centre in London, UK.ResultsSeventy per cent of men investigated for sub‐fertility had ≥1 LSF, and twenty‐nine per cent had ≥2 LSF. Excessive alcohol consumption was the most common LSF (40% respondents). Seventeen per cent of respondents used recreational drugs (RD) regularly, but only 32% of RD users believed RD impair male fertility. Twenty‐five per cent of respondents were smokers, which is higher than the UK average (20%). Twenty‐seven per cent of respondents had a waist circumference (WC) >36 inches (91 cm), and 4% had WC >40 inches (102 cm). Seventy‐nine per cent of respondents wanted further lifestyle education to improve their fertility.ConclusionsOur data suggest that men with sub‐fertility are as follows: (a) exposed to one or more LSF; (b) have incomplete education about how LSF may cause male sub‐fertility; (c) want more education about reducing LSF. Further studies are needed to investigate the potential of enhanced education of men about LSF to treat couples with sub‐fertility.
High prevalence of Bardet‐Biedl syndrome in La RéunionIsland is due to a founder variant in ARL6/BBS3
Authors: Gouronc Aurélie , Zilliox Vincent , Jacquemont Marie‐Line , Darcel Françoise , Leuvrey Anne‐Sophie , Nourisson Elsa , Antin Manuela , Alessandri Jean‐Luc , Doray Bérénice , Gueguen Paul , Payet Frédérique , Randrianaivo Hanitra , Stoetzel Corinne , Scheidecker Sophie , Flodrops Hugues , Dollfus Hélène , Muller Jean 
Published: May 2020

AbstractBardet‐Biedl syndrome (BBS) is a rare ciliopathy with variable retinal dystrophy, polydactyly, renal abnormalities, obesity, cognitive impairment, and hypogonadism. Biallelic pathogenic variants have been identified in 24 genes, leading to BBS in an autosomal recessive inheritance pattern. In this study, we investigated a cohort of 16 families (20 individuals) presenting with typical BBS originating from La Réunion Island using sequencing (Sanger and high‐throughput methods) and SNP array. In eight families (12 individuals) we identified the same ARL6/BBS3 variation [c.535G > A, p.(Asp179Asn)]. Bioinformatics and functional analyses revealed an effect of this variant on the splicing of ARL6/BBS3. Owing to the relatively high frequency of this variant, a possible founder effect was suspected. Genotyping of six individuals revealed a common 3.8‐Mb haplotype and estimated the most recent common ancestor to about eight generations confirmed by the known genealogy. Knowledge of this founder effect modifies our diagnostic strategy and enables a personalized genetic counseling for patients from La Réunion Island. Being the first description of BBS patients from La Réunion Island, we could estimate its prevalence between ~1/45000 and ~ 1/66000 individuals.
Metastasis predictors for neck sublevel IIb in papillary thyroid carcinoma
Authors: Prstačić Ratko , Bumber Boris , Marjanović Kavanagh Marcel , Jurlina Martin , Ivković Irena , Prgomet Drago 
Published: May 2020

AbstractObjectiveTo investigate possible metastasis predictors for neck sublevel IIb in papillary thyroid carcinoma (PTC) with lateral neck metastasis and to determine the reliability of preoperative ultrasound‐guided fine‐needle aspiration biopsy (FNAB) as a method of detecting positive lymph nodes in sublevel IIa in comparison with the finding of definitive pathohistological analysis.DesignProspective study with patients with proven lateral neck metastases from PTC at the time of initial diagnosis. All patients had total thyroidectomy, central neck dissection (level VI) and selective neck dissection (levels II‐V). Potential predictive factors for the occurrence of metastasis in sublevel IIb were analysed. Sensitivity and specificity tests were used to determine the reliability of preoperative ultrasound‐guided FNAB. Patients were monitored for recurrence for at least ten years.SettingSingle‐centre study.ParticipantsStudy included 53 patients with proven lateral neck metastases from PTC at the time of initial diagnosis.ResultsPredictive factors for the occurrence of metastasis in sublevel IIb that have reached statistical significance are positive sublevel IIa, number of positive lymph nodes and positive levels IIa + III + IV + V. None of the patients who fulfilled predefined criterion for minimum 10‐year follow‐up had local recurrence in operated lateral levels.ConclusionHighest clinical significance has positivity of sublevel IIa. Therefore, it is necessary to prove or exclude metastasis in sublevel IIa, preoperatively or intraoperatively, to decide whether to include sublevel IIb in dissection. Preoperative ultrasound‐guided FNAB is a reliable method for the detection of positive lymph nodes in sublevel IIa in comparison with the definitive histopathological analysis.
A new measurement tool to assess the deliberate overfeeding of others: The Feeder questionnaire
Authors: Ogden Jane , Cheung Bobo , Stewart Sarah‐Jane F. 
Published: May 2020

SummaryWhilst overeating is often influenced by others in an implicit way, people may also explicitly encourage others to overeat. This has been labelled being “a Feeder” but to date, this more deliberate trait remains neglected. This study aimed to conceptualize being “a Feeder” in terms of motivations and behaviour and to operationalize this construct with a new measurement tool through five stages with three discrete samples. Using the definition of a Feeder as “someone who offers others food even when they are not hungry” a preliminary qualitative study (n = 5) clarified the behaviour of a Feeder and revealed six motivations for such feeder behaviour. These six motivational dimensions and the feeder behaviours were operationalized with individual items and the psychometric properties of the scale were assessed using two independent samples (n = 116; n = 113). The final 27‐item measure consisted of six motivational factors (affection; waste avoidance; status; hunger avoidance; offloading; manners) and one behaviour factor, all with good internal consistency (α ≥ .7). The two samples were then merged (n = 229) to describe motivations and behaviour and to assess the association between them. The best predictors of feeder behaviour were love, offloading, manners and status. This new Feeder questionnaire has a strong factor structure and good internal consistency and could be used for further research or clinical practice.
Understanding conflicting cultural models of outdoor cats to overcome conservation impasse
Authors: Leong Kirsten M. , Gramza Ashley R. , Lepczyk Christopher A. 
Published: May 2020

AbstractMany conservation conflicts are scientifically complex yet are rooted in value conflicts, which result in an impasse. Additional biological information alone is insufficient to resolve this type of conflict. Conceptual models that articulate the material aspects of a system are increasingly used to identify areas where parties disagree. Yet, modeling processes typically follow the conveners’ rules for discussing and assessing the topic, which can exacerbate conflict. Researchers have identified a need for processes that require participants to reflect on the limits of their own philosophical assumptions and acknowledge other perspectives. Cultural models are a promising tool for this purpose because they include nonmaterial beliefs, morals, and values that guide people's understanding of how to interact with an issue, sometimes subconsciously. We explored how cultural models used with conceptual models can improve understanding of value conflicts and used outdoor cat management as a case study. We conducted interviews and focus group discussions with wildlife conservation and cat welfare professionals involved in outdoor cat policy discussions in Hawaii and Washington, D.C. From these conversations, we developed a conceptual model of the outdoor cat management system and cultural models that led stakeholders to weigh elements of the conceptual model differently. Although wildlife conservation professionals generally spoke about outdoor cats as invasive species, cat welfare professionals spoke about them as homeless pets. These conflicting conceptualizations of what an outdoor cat is may help explain the root of many long‐standing disagreements. Examining how and when stakeholders invoke different cultural models allowed us to identify management actions that work with, rather than challenge, those models. Dialogue that embraces conflicting cultural models can be difficult and uncomfortable, but has great potential to overcome conservation impasse and achieve lasting conservation results.
Poikilodermatous plaque‐like hemangioma: A benign vasoformative entity with reproducible histopathologic and clinical features
Authors: Sullivan Marguerite , Hartman Rebecca , Mahalingam Meera 
Published: May 2020

AbstractPoikilodermatous plaque‐like hemangioma (PPLH) is a recently described benign vasoformative entity with only 16 cases reported to date. We present an additional case of a 90‐year‐old male who presented with a 2‐year history of a relatively large, asymptomatic, atrophic plaque on his left buttock. The lesion was initially smaller and grew before stabilizing in size. The patient denied preceding trauma or injury at this site as well as the presence or history of any similar lesions elsewhere. Physical examination revealed a reniform atrophic pink plaque with peripheral hyperpigmentation and overlying cigarette paper wrinkling. Given this appearance, scar or post‐inflammatory changes were favored clinically, but lack of preceding trauma raised clinical concerns for poikilodermatous mycosis fungoides. Given the location and appearance, a broad shave biopsy was performed to rule out mycosis fungoides. Histopathologic examination revealed an increased density of superficial endothelial‐cell‐lined vessels, telangiectasias with sludging and congestion of superficial dermal vessels and loss of elastic tissue fibers in the lesional area. These findings, in the context of the clinical history, were consistent with this newly described hemangioma. We present this case to increase awareness amongst dermatopathologists of the reproducible clinical and histopathologic findings of this new benign vasoformative entity.
Intermittent fasting and ‘metabolic switch’: Effects on metabolic syndrome, prediabetes and type 2 diabetes
Authors: Rajpal Aman , Ismail‐Beigi Faramarz 
Published: May 2020

AbstractVarious intermittent fasting (IF) dietary plans have gained popularity among obese individuals in recent years as a means of achieving weight loss. However, studies evaluating the effect of IF regimens in people with metabolic syndrome, prediabetes and type 2 diabetes (T2D) are limited. The aim of the present review was to briefly elucidate the biochemical and physiological mechanisms underlying the positive effects of IF, especially the effect of the proposed ‘metabolic switch’ on metabolism. Next, we examined the efficacy and safety of IF regimens in individuals with metabolic syndrome, prediabetes and T2D. To achieve this, we performed a MEDLINE PubMed search using combinations of various IF terms, including trials in which participants met the additional criteria for metabolic syndrome, prediabetes or T2D. We found four studies in individuals with metabolic syndrome, one study in people with prediabetes, and eight studies in people with T2D evaluating the effects of different IF regimens. The limited available evidence, with small sample sizes and short trial durations, suggests that IF regimens have a similar effectiveness compared with calorie‐restriction diets for weight loss and improvement in glycaemic variables. In general, most IF regimens are effective and safe. However, there is an increased risk of hypoglycaemia in patients with T2D who are treated with insulin or sulphonylureas. Moreover, long‐term adherence to these regimens appears uncertain. There is a need for large controlled randomized trials to evaluate the efficacy of IF regimens, especially in individuals with metabolic syndrome and prediabetes. If proven to be sustainable and efficacious for prolonged periods, IF could offer a promising approach to improving health at the population level, and would result in multiple public health benefits.
Hemodynamic principles of prosthetic aortic valve evaluation in the transcatheter aortic valve replacement era
Authors: Abbas Amr E. , Mando Ramy , Hanzel George , Goldstein James , Shannon Francis , Pibarot Philippe 
Published: May 2020

AbstractEvaluating the hemodynamic performance of aortic valve prostheses has relied primarily on echocardiography. This involves calculating the trans‐prosthetic valve mean gradient (MG) and aortic valve area (AVA), and assessing for valvular and paravalvular regurgitation in a fashion similar to the native aortic valve. In conjunction with other echocardiographic and nonechocardiographic parameters, MG and AVA are used to distinguish between prosthesis stenosis, prosthesis patient mismatch, pressure recovery, increased flow, and measurement errors. This review will discuss the principles and limitations of echocardiographic evaluation of aortic valve prosthesis following surgical, and transcatheter aortic valve replacement and in comparison to invasive hemodynamics through illustrative clinical cases.
Development of an algorithm for automatic classification of right ventricle deformation patterns in arrhythmogenic right ventricular cardiomyopathy
Authors: Groen Marijn H. A. , Bosman Laurens P. , Teske Arco J. , Mast Thomas P. , Taha Karim , Van Slochteren Frebus J. , Cramer Maarten J. , Doevendans Pieter A. , van Es René 
Published: May 2020

AbstractBackgroundDifferent disease stages of arrhythmogenic right ventricular cardiomyopathy (ARVC) can be identified by right ventricle (RV) longitudinal deformation (strain) patterns. This requires assessment of the onset of shortening, (systolic) peak strain, and postsystolic index, which is time‐consuming and prone to inter‐ and intra‐observer variability. The aim of this study was to design and validate an algorithm to automatically classify RV deformation patterns.MethodsWe developed an algorithm based on specific local characteristics from the strain curves to detect the parameters required for classification. Determination of the onset of shortening by the algorithm was compared to manual determination by an experienced operator in a dataset containing 186 RV strain curves from 26 subjects carrying a pathogenic plakophilin‐2 (PKP2) mutation and 36 healthy subjects. Classification agreement between operator and algorithm was solely based on differences in onset shortening, as the remaining parameters required for classification of RV deformation patterns could be directly obtained from the strain curves.ResultsThe median difference between the onset of shortening determined by the experienced operator and by the automatic detector was 5.3 ms [inter‐quartile range (IQR) 2.7–8.6 ms]. 96% of the differences were within 1 time frame. Both methods correlated significantly with ρ = 0.97 (P < .001). For 26 PKP2 mutation carriers, there was 100% agreement in classification between the algorithm and experienced operator.ConclusionThe determination of the onset of shortening by the experienced operator was comparable to the algorithm. Our computer algorithm seems a promising method for the automatic classification of RV deformation patterns. The algorithm is publicly available at the MathWorks File Exchange.
Students' self‐confidence and perceived quality of prosthodontics education: A study in the Faculty of Dental Medicine of the University of Porto
Authors: Sampaio‐Fernandes Margarida , Dutra Maria , Oliveira Susana João , Reis‐Campos José Carlos , Azevedo Álvaro , Figueiral Maria Helena 
Published: May 2020

AbstractIntroductionOral rehabilitation with removable dentures (RDs) is still a viable choice for the edentulous population. Fostering students' confidence in prosthodontic procedures should be a major concern in dental schools. This study has three purposes: (a) to measure the self‐reported confidence levels of undergraduate dental students when performing removable prosthodontic treatments; (b) to evaluate the students' perceived quality of removable prosthodontics education; and (c) to assess the students' suggestions to improve removable prosthodontics education.Materials and MethodsAn anonymous questionnaire was delivered to third‐, fourth‐ and fifth‐year students of the Faculty of Dental Medicine of the University of Porto (FMDUP) (n = 176). Data from quantitative questions were statistically analysed with IBM SPSS Statistics for Windows (V.24.0), whilst qualitative data were clustered into topics and analysed in Excel.ResultsWith a 100% response rate, most students felt “confident” and “very confident” in RD clinical procedures. Overall, the 5th‐year students had higher confidence than 4th‐year ones, except when surveying diagnostic casts. Our findings also revealed that students considered the removable prosthodontics education “Good” and “Very good,” and their main suggestions were related to increasing the time allocated to clinical practice.ConclusionsStudents' confidence in carrying out removable prosthodontic procedures grew as they progressed through the course. Overall, the students' evaluation of the quality of prosthodontics education was positive, and their main suggestion to improve their confidence levels was increasing the clinical experience.
X‐ray computed tomography imaging of solute movement through ridged and flat plant systems
Authors: Scotson Callum P. , Duncan Simon J. , Williams Katherine A. , Ruiz Siul A. , Roose Tiina 
Published: May 2020

AbstractThe aim of this investigation was to experimentally compare the movement of a solute through soils with two field‐representative surface geometries: ridge and furrow surfaces versus flat surfaces. X‐ray computed tomography (XCT) imaging was undertaken to trace the movement of a soluble iodinated contrast medium, here used as an XCT‐visible analogue for field‐applied solutes, through soil columns with either a ridge and furrow or flat soil surface geometry. In addition to the soil surface geometry, the experimental treatments included the presence or absence of plants and surface water ponding. Experimental results were compared to existing numerical simulations adapted to represent the present experimental column systems. Similar infiltration patterns were observed in imaging results and the numerical simulations for most treatments. The experimental results suggest that plant roots present a significant localized effect to reduce the infiltration depth of solutes, particularly in planted ridges where the infiltration depth of the contrast medium was minimal. There is variability within the results because the number of replicates was limited to three due to the exploratory nature of the study (testing eight different treatments) and the cost and availability of XCT facilities capable of imaging such physically large samples. Discrepancies between the imaged infiltration depth of the solute and the numerical simulations are attributed to variation in plant root distribution and also spatial soil moisture, as measured using resistive soil moisture sensing. The results of this investigation elucidate the nature of solute movement through soil surface geometries, indicating that plant root water uptake can reduce solute infiltration depth, but surface ponding can negate this. These results suggest that soil surface shape, plant age and the timing of solute application with anticipated rainfall could be important considerations for reducing solute leaching and improving solute application efficiency.Highlights
Investigating factors affecting solute infiltration in flat or ridge and furrow soil geometries.
X‐ray CT imaging traces soluble contrast media movement in soil columns and is compared to modelling.
Plant root water uptake can reduce solute infiltration depth, but surface ponding can negate this.
Considering soil surface shape, rain and plant age in solute application could reduce leaching.