bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMAÇÃO PEDAGÓGICA DO TECNÓLOGO PARA ATUAÇÃO COMO DOCENTE NO INSTITUTO FEDERAL DO AMAPÁ – CAMPUS MACAPÁ
Authors: Sousa Elisabete Piancó , De Sales Adriana Lucena , Da Silva José Dario Pintor , Lemos Danielle Martins , França Elícia Thanes Silva Sodré 
Published: January 2020

O docente que possui qualquer formação inicial que não seja a licenciatura necessita de uma complementação pedagógica para atuar na docência. Para isso, nos últimos anos os IFs vêm buscando implantar cursos de formação pedagógica, haja vista habilitar e capacitar os docentes que ainda não possuem tal formação. Nesse estudo objetivou-se avaliar a importância da formação pedagógica do tecnólogo para atuação como docente no Instituto Federal do Amapá – Campus Macapá. A pesquisa de campo foi realizada durante o ano letivo de 2017, sendo necessárias as seguintes etapas: análise documental (perfil para participar da pesquisa), aplicação dos questionários a todos os professores com a formação de tecnólogo, totalizando doze professores, sendo que apenas 9 responderam o questionário. Por meio do questionário foi possível traçar o perfil do docente, no que se refere a sexo, faixa etária, regime de trabalho, formação, experiência profissional (no magistério e em outras atividades), as especificidades e os desafios da prática docente na Educação Profissinal e Tecnólogica (EPT), conforme em estudos realizado por Silva (2003) e Pena (2014) ). Todavia, todo e qualquer docente deve atender ao processo de ensino / aprendizagem, sendo que antes devem ter conhecimento das diversidades e modalidades de ensino, situações e contexto social em que os discentes vivem, de modo que atendam aos anseios da sociedade como um todo. Os docentes que participaram dessa pesquisa salientaram que os cursos de formação continuada contribuem consideravelmente para a formação do tecnólogo, tendo em vista que é de suma importância para prática docente no sentido de aprimoramento de métodos de avaliações, aulas inovadoras, construção de provas contextualizadas, conhecer novas perspectivas sobre o ensino e regulamentações voltadas para atuação docente. Na dinâmica ensino / aprendizagem os docentes necessitam de capacitação para atender de forma satisfatória as diferentes modalidades de ensino e diversidade de cursos ofertados pela Instituição.
OS INSTITUTOS FEDERAIS E O DESENVOLVIMENTO REGIONAL: INTERFACE POSSÍVEL
Authors: Pereira Luiz Augusto Caldas , Da Cruz José Luis Vianna 
Published: January 2020

A Educação Profissional e Tecnológica experimentou significativas transformações a partir de 2003, com a expansão da Rede Federal de Educação Profissional Científica e Tecnológica e a criação dos Institutos Federais de Educação Ciência e Tecnologia - Institutos Federais. O artigo analisa as possibilidades dessas transformações em contr. ibuir para o desenvolvimento e a integração regionais, na medida em que esta é uma das suas diretrizes. Apresenta os critérios de localização dos campi e as prerrogativas dos Institutos Federais; e discute caminhos para a contribuição da Educação Profissional e Tecnológica e dos Institutos Federais ao desenvolvimento regional. Constata-se que os critérios de localização dos novos campi possibilitaram a sua difusão em regiões periféricas e em mesorregiões que podem ter a sua dinâmica socioeconômica positivamente impactada, numa perspectiva de políticas intersetoriais voltadas para o desenvolvimento regional
Conversion of Palm Oil Mill Effluent on Biogas Production with Consortium Bacteria
Authors: Utami Nyimas Ulfatry , Said Muhammad , Faizal Muhammad , Komariah Leily Nurul 
Published: January 2020

Palm Oil Mill Effluent (POME) is a liquid waste that has a high organic content and it can be fermented using bacteria to produce biogas. POME is non-toxic but the high organic contents can disturb the ecosystems and cause the environmental pollution in the water body. POME contains microorganisms that have the potential to hydrolyze oils, celluloses, and protein. Potential bacteria for degradation of POME can be obtained by isolating the waste itself (indigenous bacteria). Indigenous bacteria that have been isolated from POME, namely: Stenotrophomonas rhizopila strain E-P10 (KP 1.2) and Bacillus toyonensis strain BCT-7112 (KAN 1) are used as consortium bacteria in the process of waste degradation. The research sequence consists of rejuvenation of bacteria, preparation of medium mineral, starter and bacterial inoculum. The research aims to degrade the substrates from POME using a consortium and indigenous bacteria to produce biogas. The substrate degradation process is carried out in a bioreactor with degradation time 0, 20, 21-22, 23-26, 27-30, 31-34 and 35-38 days. Bacterial population growth was calculated using a haemacytometer. The highest population of the consortium and indigenous bacteria were found at 7.94x107 mg/mL and 7.23x107 mg/mL. The biogas contents were analyzed using the Gas Chromatography (GC) with units of % mole. The highest production of biogas contains 68.6 % mole methane gas (CH4) and 21.7 % mole carbon dioxide gas (CO2) with the consortium bacteria. While using the KAN 1 bacteria, the highest production of biogas contains 64.0 % mole methane gas (CH4) and 22.0 % mole carbon dioxide gas (CO2).
Phytochemical study of <i>Tribulus Terrestris</i> L.
Authors: Affaf A. , Karpenko Yu. N. , Gulyaev D. K. , Belonogova V. D. , Molokhova E. I. , Blinova O. L. , Gileva A. A. 
Published: January 2020

Tríbulus terrestris L., an annual herb belonging to the Zygophyllaceae family and growing in moderate and tropical climates, has a rich chemical composition of biologically active substances and chemical elements.The aim of the work is a phytochemical study of Tribulus terrestris L. growing in different geographical zones.Materials and methods. The objects of study were herb specimens of Tribulus terrestris L. collected in different habitats. The samples of the raw materials were shade-dried. The determination of saponins in the raw materials, was carried out by high performance liquid chromatography with a mass spectrometric detection (HPLC-MS / MS). The study of the qualitative and quantitative composition of the elements was carried out on an X-ray fluorescence spectrometer.Results. The saponins had been studied by HPLC-MS/MS, according to which in all the studied samples, dioscin and protodioscin were found. Their retention times coincided with the retention times of dioscin and protodioscin standards. It has been established that among the macroelements of Tríbulus terrestris L., potassium and calcium are mostly accumulated. They account for about 90% of the total content of the elements in the plant. It has been revealed that the distribution of macroand microelements in the plant, varies significantly depending on their place and growing conditions.Conclusion. The maximum dioscin content was observed in the samples harvested in Moldova, and the minimum – in the samples from the nursery garden of the All-Russian Scientific Research Institute of medicinal and aromatic plants. The largest amount of protodioscin was found out in the samples from the Crimea, and the minimum – in the samples from Moldova. The carried out study of the elements content of Tríbulus terrestris L. showed that the habitats (geographical zones) in which the studied samples of raw materials had been were collected, affect the accumulation of the elements by the plant. Based on the data obtained, biological absorption series have been compiled for the samples from each habitat.
Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2
Authors: Thamrin Husin , Sutjahjo Ari , Pranoto Agung , Soelistijo Soebagijo Adi 
Published: January 2020

Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031 Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.
The Comparison of Breast milk from Mother with Preterm Infant at 4o C Temperature in 0, 24 and 48 Hours on Bacterial Growth
Authors: Saputra Pandit Bagus Tri , Rochmah Nur , Wiqoyah Nurul 
Published: January 2020

Introduction: Preterm and fullterm breast milk has different leukocyte and bioactive concentration, which affect it’s bactericidal activity and storage duration. The preterm breast milk potentially has longer storage duration than fullterm breast milk The research and guideline about the acceptable of storage duration of preterm breast milk at 4o C was limited. The objective of this study was to assess the correlation of storage duration of preterm breast milk preterm baby at 4o C temperature on bacterial growth.Methods: The study design was experimental using pre-post control groups design. We used 9 samples of breast milk which met the inclusion criteria divided into 3 groups. The first, second and third groups was storage in 4o C for 0, 24 and 48 hours respectively before the inoculation to the culture media.Results: After the samples were kept at 4o C temperature for 0, 24 and 48 hours, the mean bacterial colony forming unit for each group were 92 (±SD 112), 79 (±SD 97) and 63 (±SD 73) CFU respectively. Compared to the first group, the second and third group has lower bacterial colony forming unit but no significant differences statistically (P= 0.214 and P=1.39 respectively). Likewise there was no significant bacterial colony forming unit between second and third group (P=0.086).Conclusion: Storage of preterm breast milk in 4o C for 24 and 48 hours show no change in total bacterial colony count (TBCC)..
Characterization of Multiphase Flow in CHOPS Processes Using a Systematic Framework
Authors: Fan Zhaoqi , Yang Daoyong , Li Xiaoli 
Published: January 2020

Summary
Cold heavy oil production with sand (CHOPS) technique has successfully improved oil recovery from heavy oil reservoirs due to high permeability channels resulted from sand failure and foamy oil flow enhancing heavy oil movability. However, impacts of the sand failure and the foamy oil flow on multiphase fluid flow features are still not properly understood. In this paper, an effective and systematic framework has been proposed to characterize the multiphase fluid flow and determine the three-phase relative permeability of CHOPS processes. A recently developed sand failure criterion and a relative permeability model have been integrated with a reservoir simulator to simulate the CHOPS process. The unknown parameters involved in the systematic framework are intelligently determined by an iterative ensemble smoother (IES) algorithm, which also enables sensitivity analysis on CHOPS production profiles. Subsequently, the proposed framework is tested through a laboratory CHOPS experiment. We obtained not only fairly history-matched production data (i.e., cumulative oil, gas, and sand production), but also satisfactorily converged three-phase relative permeability curves by iteratively assimilating production profiles of the CHOPS experiment. It has also been found that using two sets of three-phase relative permeability is capable of representing the segment-type nature of the multiphase flow and reproducing the transition stage on the production profiles. Furthermore, the comparison between two sets of three-phase relative permeability indicates that the sand failure phenomenon yields a reduced residual oil saturation and an increased oil/gas relative permeability. In addition, the sensitivity analysis demonstrates that the segment-type nature of production profiles results from the variation of key impact factors dominating the multiphase fluid flow in CHOPS processes. Overall, the proposed systematic framework can not only reproduce the physical phenomena of sand failure and foamy oil, but also provide a convenient tool to characterize the multiphase flow in CHOPS processes.
Flow-controlled ventilation (FCV) improves regional ventilation in obese patients – a randomized controlled crossover trial
Authors: Weber Jonas , Straka Leonie , Borgmann Silke , Schmidt Johannes , Wirth Steffen , Schumann Stefan 
Published: January 2020

Abstract
Background
In obese patients, high closing capacity and low functional residual capacity increase the risk for expiratory alveolar collapse. Constant expiratory flow, as provided by the new flow-controlled ventilation (FCV) mode, was shown to improve lung recruitment. We hypothesized that lung aeration and respiratory mechanics improve in obese patients during FCV.
Methods
We compared FCV and volume-controlled (VCV) ventilation in 23 obese patients in a randomized cross-over setting. Starting with baseline measurements, ventilation settings were kept identical except for the ventilation mode related differences (VCV: inspiration to expiration ratio 1:2 with passive expiration, FCV: inspiration to expiration ratio 1:1 with active, linearized expiration). Primary endpoint of the study was the change of end-expiratory lung volume compared to baseline ventilation. Secondary endpoints were the change of mean lung volume, respiratory mechanics and hemodynamic variables.
Results
The loss of end-expiratory lung volume and mean lung volume compared to baseline was lower during FCV compared to VCV (end-expiratory lung volume: FCV, -126 ± 207 ml; VCV, -316 ± 254 ml; p < 0.001, mean lung volume: FCV, -108.2 ± 198.6 ml; VCV, -315.8 ± 252.1 ml; p < 0.001) and at comparable plateau pressure (baseline, 19.6 ± 3.7; VCV, 20.2 ± 3.4; FCV, 20.2 ± 3.8 cmH2O; p = 0.441), mean tracheal pressure was higher (baseline, 13.1 ± 1.1; VCV, 12.9 ±1.2; FCV, 14.8 ± 2.2 cmH2O; p < 0.001). All other respiratory and hemodynamic variables were comparable between the ventilation modes.
Conclusions
This study demonstrates that, compared to VCV, FCV improves regional ventilation distribution of the lung at comparable PEEP, tidal volume, PPlat and ventilation frequency. The increase in end-expiratory lung volume during FCV was probably caused by the increased mean tracheal pressure which can be attributed to the linearized expiratory pressure decline.
Acute myeloid leukemia with inv(16)(p13.1q22) and deletion of the 5’MYH11/3’CBFB gene fusion: a report of two cases and literature review.
Authors: Lv Lili , Yu Jingwei , Qi Zhongxia 
Published: January 2020

Abstract
Background
Abnormalities of chromosome 16 are found in about 5-8% of acute myeloid leukemia (AML). The AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) is associated with a high rate of complete remission (CR) and favorable overall survival (OS) when treated with high-dose Cytarabine. At the inversion breakpoints, deletion of 3’ CBFB has been reported, but most of them were studied by chromosome and fluorescence in situ hybridization (FISH) analyses. The genomic characteristics of such deletions remain largely undefined, hindering further understanding of the clinical significance of the deletions.
Case presentation
We report here two AML cases with inv(16) and deletion of the 5’ MYH11 /3’ CBFB gene fusion, which were characterized by chromosome, FISH, and single nucleotide polymorphism (SNP) microarray analyses. Both cases have achieved CR for more than three years.
Conclusions
Deletion of 3’ CBFB in AML with inv(16) is also accompanied with deletion of 5’ MYH11 in all the cases studied by SNP microarray, suggesting that 3’ CBFB and 5’ MYH11 were most likely deleted together as a fusion product of inv(16) instead of occurring separately. In concert with the findings of other published studies of similar patients, our study suggests that deletion of 5’ MYH11 /3’ CBFB in AML with inv(16) may not have negative impact on the prognosis of the disease.
Critical pathways and factors of non-health outcomes affecting self-care behaviors in patients with type 2 diabetes and their differences in patient preference in medical decision-making
Authors: Wang Ming-Jye , Lin Hung-Ming , Hung Li-Chen , Lo Yi-Ting 
Published: January 2020

Abstract
Background The effects of patient sustained self-care behaviors (SCB) on glycemic control are even greater than the effects of medical treatment, indicating the value of identifying the factors that influence SCB. To date, these factors have not been placed in one model to clarify the critical path affecting SCB. The aims of this study were to explore the relationships of these factors and the differences by decision-making preference.Methods A cross-sectional study was conducted among outpatients with type 2 diabetes at a regional teaching hospital. Purposive sampling was adopted to recruit 316 eligible patients via self-administered questionnaires. Partial least squares structural equation modeling was used for analysis.Results Significant direct pathways were identified from health literacy (HL) to self-efficacy (SE), patient empowerment (PE), and SCB; from SE to SCB; and from PE to SCB. Indirect pathways were from HL to SCB via SE or PE. The pathway from HL to SE was significantly stronger in those preferring shared decision-making than in those who preferred physician decision-making.Conclusions HL is a critical factor in improving SCB in patients with type 2 diabetes, and the pathway from HL to SE differed the most by patient preference for making decisions. Therefore, developing an effective promotion strategy and application tools to improve the overall HL of diabetic is the cornerstone of enhancing SCB in this population.
Analysis of Influencing Factors of Community Management of Diabetes based on Adaptive-Lasso Logistic Regression Model
Authors: Lin Wei , Huang Zejuan , Cao Zhiqing , Zhou Jing , Tian Yang , Li Jiawei , Zheng Mingyue 
Published: January 2020

Abstract
Background: Influencing factors of community management of diabetes are complex and controversial, and how to select the most effective multiple influencing factors requires in-depth research. This study aims to analyse multiple influencing factors by adaptive-lasso logistic regression model for the effectiveness of diabetes management of the community to improve the efficiency and reduce the burden of diabetes. Methods: A cross-sectional survey (N=1,127) was adopted to establish the adaptive-lasso logistic regression model of influencing factors for community management of diabetic patients based on cluster sampling data of diabetic patients in Chengdu city, China. By comparing with the full-variable logistic model and the ridge logistic model to find the advantages of the adaptive lasso-logistic regression model in community diabetes management. Results: A total of 1,127 diabetic patients were included in the cross-sectional survey. The latest fasting blood glucose was included in the analysis. Among the included population, 90.6% of them had a fasting glucose level higher than 6.1mol/L, and 9.4% of them were below 6.1mol/L. By cross-validation, after folding eight times, the variables involved in the Adaptive lasso-logistic regression model include age, education level, main source of income, marital status, average monthly income, free medical service, basic medical insurance for residents, hospital history, number of follow-up evaluations by family doctor team, voluntary participation in community blood glucose measurement. The AIC and BIC criteria of adaptive lasso-logistic regression model were 2062 and 1981, which were lower than the full-variable logistic model (2349, 2023) and the ridge logistic model (2312, 2013). From the perspective of time cost, the adaptive-lasso logistic regression model was better than the other two models. Conclusions: The adaptive-lasso logistic regression model can be used to analyse the influencing factors of community management in patients with diabetes. Community intervention and intensive management measures can significantly improve the blood glucose status of patients with diabetes.
In vitro and In vivo recombination of heterologous modular for improving biosynthesis of astaxanthin in yeast
Authors: Qi Dan-Dan , Jin Jin , Liu Duo , Jia Bin , Yuan Ying-Jin 
Published: January 2020

Abstract
Bacground: Astaxanthin is a kind of tetraterpene with strong antioxygenic property. Concerning the safety and economy issue the biosynthesis of astaxanthin has greater potential than chemical synthesis and extraction from natural producers. However, the production of astaxanthin in microorganism is still limited by the poor efficiency of heterologous pathway.Results: To address the bottleneck of astaxanthin yield in microbe, we developed the in vitro and in vivo recombination methods to optimize the combination of heterologous modular ofβ-carotene ketolase (crtW) and hydroxylation (crtZ) from different species in engineered yeast strains. Finally, the astaxanthin yield of in vitro recombination and in vivo recombination were enhanced 2.11- to 8.51-fold and 3.05- to 9.71-fold compared to the parent strains, respectively. The highest astaxanthin producing yeast yQDD022 was obtained by the in vivo recombination with 6.05mg/g DCW of the astaxanthin yield. Moreover, it is demonstrated that the astaxanthin producing yeast of the in vivo recombination has higher efficiency and stability than that of the in vitro recombination.Conclusions: Recombination of heterologous modular by in vitro and in vivo provides a simple and efficient way to improve the astaxanthin yield in yeast. Both the in vitro and in vivo recombination methods enable high throughput screening of heterologous pathway by combining crtW and crtZ from different species. And the heterologous pathway constructed by the in vivo recombination is more stable than that of the in vitro recombination. This study not only found the underlying optimal combination of crtZ and crtW, but also provided a reference to greatly enhance desired compounds accumulation by evolving heterologous pathway.