bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced strength of cyclically preloaded arrays of pillars
Authors: Derda Tomasz , Domanski Zbigniew 
Published: June 2020

AbstractUnder compression, a cyclically precompressed nanopillar supports greater load than its as-fabricated counterpart. Such an improvement on mechanical properties takes place only when the preloading process is tuned carefully with regard to a particular pillar being tested. This experimental evidence raises a question: does a cyclic preloading applied simultaneously to an ensemble of nanopillars enhance the overall strength of the system? To answer this question, we simulate numerically cyclic loadings of pillars assembled into an array. Assuming that the pillars are characterized by random strength-thresholds $$\left\{ \sigma _{\mathrm{th}}\right\} $$

σ
th

, we demonstrate that quasi-statically compressed arrays with initial cycling process support higher load than the corresponding ones with no precompression. By applying the fibre bundle model, we evolve $$\left\{ \sigma _{\mathrm{th}}\right\} $$

σ
th

and estimate that the mean strengthening may attain 7–9% for an optimally tailored cycling.
The long-term consequence of salivary contamination at various stages of adhesive application and clinically feasible remedies to decontaminate
Authors: Nair Pooja , Ilie Nicoleta 
Published: June 2020

Abstract
Objective
To analyse the bond quality in dentine post-ageing after salivary contamination and decontamination at different stages of dental adhesive application.

Materials and methods
A total of 1120 human dentine specimens were randomly allocated to 14 groups for four intervals (n = 20) to be treated with a self-etching (SE) and universal (U) adhesive. The saliva contamination and decontamination were implemented after surface preparation, after primer application (for SE) and after adhesive curing. The decontamination groups were either rinsed and air-dried or rinsed, air-dried and reapplied with adhesive. They were stored (37 °C, distilled water) for four intervals (1 week, 1 month, 3 months and 1 year) and subjected to shear bond strength (SBS) test at a crosshead speed of 0.5 mm/min.

Result
One-way ANOVA with Tukey’s test (α = 0.05) revealed significant reduction in SBS in all the groups in U adhesive compared with the control group at 1 week (p < 0.0001) and in SE when the contamination took place after primer application. However, decontamination improved the SBS in SE but not in U adhesive. The univariate analysis confirmed significant influences (p < 0.0001) seen by treatment procedure ($$ {\eta}_{\mathrm{p}}^2 $$

η
p
2

=0.075), type of adhesive ($$ {\eta}_{\mathrm{p}}^2 $$

η
p
2

= 0.328), ageing ($$ {\eta}_{\mathrm{p}}^2 $$

η
p
2

= 0.13), experimental groups ($$ {\eta}_{\mathrm{p}}^2 $$

η
p
2

= 0.518), and the stage of influence ($$ {\eta}_{\mathrm{p}}^2 $$

η
p
2

= 0.60).

Conclusion
Saliva contamination is detrimental after primer application in SE but, decontamination regained the SBS and maintained it over time. In U adhesive, SBS deteriorated over time irrespective of the contamination.

Clinical relevance
Salivary contamination showed different influences on SBS at various stages of restoration with contemporary dental adhesives.
Dysphagia in neurological diseases: a literature review
Authors: Panebianco M. , Marchese-Ragona R. , Masiero S. , Restivo D. A. 
Published: June 2020

AbstractDysphagia is defined as an impairment of this complex and integrated sensorimotor system. It is estimated that 400,000 to 800,000 individuals worldwide develop neurogenic dysphagia per year. Neurogenic dysphagia is typically occurring in patients with neurological disease of different etiologies. A correct and early diagnosis and an appropriate management of dysphagia could be useful for improving patient’s quality of life and may help to prevent or delay death. In the present review, we discuss thoroughly the anatomy and physiology of swallowing and also the pathophysiological mechanisms involved in impaired swallowing, as well as the diagnosis, management, and potential treatments of neurogenic dysphagia. Assessment of neurogenic dysphagia includes medical history, physical exam, and instrumental examinations (fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, electromyography). Pharmacological treatment of these problems includes oral anticholinergic drugs. Surgical myotomy of the cricopharyngeal muscle showed an important improvement of oropharyngeal dysphagia associated to upper esophageal sphincter hyperactivity. Chemical myotomy of the upper esophageal sphincter by local injections of botulinum toxin type A into the cricopharyngeal muscle has been proposed as an alternative less invasive and less unsafe than surgical myotomy.
SURE — EU Capacity for Stabilising Employment and Incomes in the Pandemic
Authors: Andor László 
Published: June 2020

AbstractOn 2 April 2020, the European Commission (2020) duly put forward a proposal for the creation of a European instrument for temporary Support to mitigate Unemployment Risks in an Emergency (SURE). This bold and innovative move must be welcome, but the actual profile of this new instrument requires clarification to avoid misunderstandings, false expectations and eventual disappointment.
Potential Output, EU Fiscal Surveillance and the COVID-19 Shock
Authors: Heimberger Philipp 
Published: June 2020

AbstractThis paper discusses how the technical foundations of the EU’s fiscal rules constrain the fiscal space in EU countries in the context of the COVID-19 pandemic. We review the evidence on how estimates of potential output, which are at the heart of essential control indicators in EU fiscal surveillance, were revised in the ten years running up to the COVID-19 pandemic, and how these revisions affected the fiscal stance of EU countries. We provide first evidence for downward revisions in the European Commission’s potential output estimates against the background of the COVID-19 shock across the EU27 countries, and we assess the potential consequences in terms of fiscal space. According to our results, one additional percentage point in predicted losses of actual output is associated with a loss in potential output of about 0.6 percentage points. Given the importance of model-based estimates in the EU’s fiscal rules, avoiding pro-cyclical fiscal tightening will require that policymakers’ hands are not tied by overly pessimistic views on the development of potential output.
Great Green Transition and Finance
Authors: Kemfert Claudia , Schäfer Dorothea , Semmler Willi 
Published: June 2020

AbstractEuropean governments are struggling to regain economic strength in the coronavirus pandemic as in many countries the number of new infections seems to gradually subside. Growth rates deep in the red call for a reconstruction programme when the crisis is finally manageable and economic activity can resume. Amidst this, there are again influential groups that claim “this is not the time to insist on strict climate protection goals”. On the contrary, the ongoing COVID-19 crisis has clearly illustrated what climate disasters, often occurring locally, could do to the life of citizens. The reconstruction programme needs to initiate the great green transition. The transformation from a climate-distorting to a climate-protecting economy opens up investment opportunities and points to financing needs comparable with those necessary for the rebuilding of the European economy after World War II. The great green transition is a unique chance to pursue policies for a new and sustainable growth regime.
Coronavirus Crisis: Government Aid That Also Promotes Employee Ownership
Authors: Ellerman David P. , Gonza Tej 
Published: June 2020

AbstractThe premise of this paper is that state aid to distressed companies should benefit not only the current owners but also the employees, who are the ones taking personal risks to continue or restart companies. Government aid during the Great Recession was aimed primarily at restoring the status quo. In the current deeper crisis, aid should be designed to create a fairer, more inclusive and more socially responsible economy by promoting employee ownership as both an incentive and a reward. We show how the Employee Stock Ownership Plan, which has been pioneered in the US for 40 years and can be adapted to the European legal context, can be used as the vehicle for structuring this aid.
Competition, Technological Change and Productivity Gains: A Sectoral Analysis
Authors: Ciriani Stéphane , Jeanjean François 
Published: June 2020

AbstractThe empirical relationship between competition intensity and the rate of productivity growth across 30 sectors of the French economy between 1978 and 2015 displays an inverted U-shape. This implies that there exists an optimal level of competition for each sector, defined by the price markup that maximises the growth rate of hourly labour productivity. As there is a significant and strong positive correlation between optimal markups and technical progress rates in each sector, it follows that sectors with high technical progress require higher markups to maximise their labour productivity growth rate. The persistence of non-optimal markups in French sectors is associated with a 0.4% loss in aggregate annual labour productivity growth during the period (1.86%). French long-term productivity growth could have reached 2.25% had markups been at their optimal level. As a result, policies to foster innovation and productivity should aim at enabling the optimal level of markup (or market power), particularly in high-innovation sectors.
High Performance Thin-Layer Chromatography of Plant Ecdysteroids Coupled with Desorption Electrospray Ionisation–Ion Mobility–Time of Flight High Resolution Mass Spectrometry (HPTLC/DESI/IM/ToFMS)
Authors: Claude E. , Tower M. , Lafont R. , Wilson I. D. , Plumb R. S. 
Published: June 2020

AbstractThe use of high performance thin-layer chromatography (HPTLC) in combination with high resolution time of flight mass spectrometry (MS) for the detection, identification and imaging (HPTLC/MSI) of ecdysteroids (insect moulting hormones) present in a number of plant extracts obtained from members of the Silene family is demonstrated. DESI is shown to be a convenient method for the recovery of these polar polyhydroxylated steroids from the silica gel of the HPTLC plate for subsequent MS detection and imaging. The incorporation of an ion mobility separation (IMS) to the system to give HPTLC/IMS/MS provided additional drift time data which enabled more confident identification. Using HPTLC/DESI/IMS/MS, a range of ecdysteroids were detected and characterized in extracts of S. otitis, S nutans, S. maritime, S. viridiflora and S. fimbriata.
Evaluating causes of algorithmic bias in juvenile criminal recidivism
Authors: Miron Marius , Tolan Songül , Gómez Emilia , Castillo Carlos 
Published: June 2020

AbstractIn this paper we investigate risk prediction of criminal re-offense among juvenile defendants using general-purpose machine learning (ML) algorithms. We show that in our dataset, containing hundreds of cases, ML models achieve better predictive power than a structured professional risk assessment tool, the Structured Assessment of Violence Risk in Youth (SAVRY), at the expense of not satisfying relevant group fairness metrics that SAVRY does satisfy. We explore in more detail two possible causes of this algorithmic bias that are related to biases in the data with respect to two protected groups, foreigners and women. In particular, we look at (1) the differences in the prevalence of re-offense between protected groups and (2) the influence of protected group or correlated features in the prediction. Our experiments show that both can lead to disparity between groups on the considered group fairness metrics. We observe that methods to mitigate the influence of either cause do not guarantee fair outcomes. An analysis of feature importance using LIME, a machine learning interpretability method, shows that some mitigation methods can shift the set of features that ML techniques rely on away from demographics and criminal history which are highly correlated with sensitive features.
Welfare and Trade Effects of International Environmental Agreements
Authors: Montagna Catia , Pinto Avanti Nisha , Vlassis Nikolaos 
Published: June 2020

AbstractWe analyse the welfare effects of environmental policy arising from the formation of an international environmental agreement on the participating and non-participating countries and thus shed light on the potential incentives for a country to join such an agreement. Within aN-countryQ-goods general equilibrium framework under free-trade conditions, we consider unilateral and cooperative policy settings and, within the latter, country-specific and fully harmonized policies within the agreement. A key result of the paper is the emergence of a negative relationship, arising from terms of trade effects, between the welfare changes of the participating and non-participating countries following the formation of the agreement. These however do not result in a zero sum welfare outcome for the world as a whole.
Explaining Why There is Something Rather than Nothing
Authors: Brenner Andrew 
Published: June 2020

AbstractIt is sometimes supposed that, in principle, we cannot offer an explanation for why there is something rather than nothing. I argue that this supposition is a mistake, and stems from a needlessly myopic conception of the form explanations can legitimately take. After making this more general point, I proceed to offer a speculative suggestion regarding one sort of explanation which can in principle serve as an answer to the question “why is there something rather than nothing?” The suggestion is that there may be something rather than nothing in virtue of the truth of certain sorts of subjunctive conditionals.
Understanding Technology as Situated Practice: Everyday use of Voice User Interfaces Among Diverse Groups of Users in Urban India
Authors: Kendall Linus , Chaudhuri Bidisha , Bhalla Apoorva 
Published: June 2020

AbstractAs smartphones have become ubiquitous across urban India, voice user interfaces (VUIs) are increasingly becoming part of diverse groups of users’ daily experiences. These technologies are now generally accessible as a result of improvements in mobile Internet access, [-8.5pc]Biography is Required. Please provide. introduction of low-cost smartphones and the ongoing process of their localisation into Indian languages. However, when people engage with technologies in their everyday lives, they not only enact the material attributes of the artifact but also draw on their skills, social positions, prior experience and societal norms and expectations to make use of the artifact. Drawing on Orlikowski’s analytical framework of “technologies-in-practice” we engage in an interview-based exploratory study among diverse groups of users in urban India to understand use of VUIs as situated practice. We identify three technologies-in-practice emerging through enactment of VUIs on users’ smartphones: looking up, learning and leisure. We argue that – instead of asking why and how users appropriate VUIs – identifying different kinds of enactments of VUIs present researchers and practitioners with a more nuanced understanding of existing and potential use of VUIs across varied contexts.
Herbivory by aboveground insects impacts plant root morphological traits
Authors: Heinze Johannes 
Published: June 2020

AbstractAboveground herbivory induces physiological responses, like the release of belowground chemical defense and storage of secondary metabolites, as well as physical responses in plants, like increased root biomass production. However, studies on effects of aboveground herbivory on root morphology are scarce and until now no study tested herbivory effects under natural conditions for a large set of plant species. Therefore, in a field experiment on plant–soil interactions, I investigated the effect of aboveground insect herbivory on root morphological traits of 20 grassland plant species. For 9 of the 20 species, all individuals showed shoot damage in the presence of insect herbivores, but no damage in insect herbivore exclusions. In these 9 species root biomass increased and root morphological traits changed under herbivory towards thinner roots with increased specific root surface. In contrast, the remaining species did not differ in the number of individuals damaged, root biomass nor morphological traits with herbivores present vs. absent. The fact that aboveground herbivory resulted in thinner roots with increased specific root surface area for all species in which the herbivore exclusion manipulation altered shoot damage might indicate that plants increase nutrient uptake in response to herbivory. However, more importantly, results provide empirical evidence that aboveground herbivory impacts root morphological traits of plants. As these traits are important for the occupation of soil space, uptake processes, decomposition and interactions with soil biota, results suggest that herbivory-induced changes in root morphology might be of importance for plant–soil feedbacks and plant–plant competition.
137Cs, 40K, and K in raw and stir-fried mushrooms from the Boletaceae family from the Midu region in Yunnan, Southwest China
Authors: Falandysz Jerzy , Zhang Ji , Saniewski Michał 
Published: June 2020

AbstractThe parallel batches of the same species and geographical origin mushrooms both raw and stir-fried were investigated to get an insight into the content and intake of 137Cs, 40K, and K from mushroom meals. The Boletaceae family species (Baorangia bicolor, Boletus bainiugan, Butyriboletus roseoflavus, Retiboletus griseus, Rugiboletus extremiorientalis, and Sutorius magnificus) were collected from the Midu County (Dali Bai Autonomous Prefecture) in 2018. The activity concentrations of 137Cs in the caps of dried raw mushrooms were in the range 14 ± 1 Bq kg−1 dry biomass (db) (R. griseus) to 34 ± 2 Bq kg−1 db (R. extremiorientalis), and in stems from 16 ± 1 Bq kg−1 db (B. bicolor and B. bainiugan) to 23 ± 1 Bq kg-1 db (R. extremiorientalis). The mean activity concentration in the whole fruiting bodies in all six species was 18 ± 4 Bq kg-1 db. The activity concentrations of 137Cs were roughly the same in both dehydrated materials, stir-fried, and raw mushrooms, while the contents of 40K and stable K were around 2- to 3-fold smaller in stir-fried than raw product. The raw and stir-fried mushrooms on a whole (wet) weight basis showed activity concentrations of 137Cs in the range from 1.2 to 3.2 Bq kg−1 ww (mean 1.9 ± 0.6 Bq kg−1 ww) and 6.0 to 9.4 Bq kg−1 ww (mean 7.0 ± 1.2 Bq kg−1 ww), respectively. Evidently, when expressed on a whole (wet) weight basis, the cooked mushrooms showed on average around 3.5-fold greater activity concentration of 137Cs when compared with raw mushrooms. The 137Cs, 40K, and total K enrichment in stir-frying (in a whole (wet) weight basis for the meal), confronted with the results for dehydrated raw and fried mushrooms, show the direct correlation with loss of mass (largely moisture) during the cooking procedure but not much of 137Cs and 40K. Edible wild mushrooms from Yunnan were little contaminated with radiocaesium. As assessed, the mean radioactivity dose from natural 40K in around 9.3-fold exceeded the dose obtained for artificial 137Cs from stir-fried mushroom meals, which both were very low doses.
Hypothermic circulatory arrest induced coagulopathy: rotational thromboelastometry analysis
Authors: Ise Hayato , Kitahara Hiroto , Oyama Kyohei , Takahashi Keiya , Kanda Hirotsugu , Fujii Satoshi , Kunisawa Takayuki , Kamiya Hiroyuki 
Published: June 2020

Abstract
Objectives
Hypothermic circulatory arrest (HCA) has been considered to cause coagulopathy during cardiac surgery. However, coagulopathy associated with HCA has not been understood clearly in details. The objective of this study is to analyze the details of coagulopathy related to HCA in cardiac surgery by using rotational thromboelastometry (ROTEM).

Methods
We retrospectively analyzed 38 patients who underwent elective cardiac surgery (HCA group = 12, non-HCA group = 26) in our hospital. Blood samples were collected before and after cardiopulmonary bypass (CPB). Standard laboratory tests (SLTs) and ROTEM were performed. We performed four ROTEM assays (EXTEM, INTEM, HEPTEM and FIBTEM) and analyzed the following ROTEM parameters: clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and maximum clot elasticity (MCE). The amount of perioperative bleeding, intraoperative transfusion and perioperative data were compared between the HCA and non-HCA group.

Results
Operation time and hemostatic time were significantly longer in the HCA group, whereas CPB time had no difference between the groups. The amount of perioperative bleeding and intraoperative transfusion were much higher in the HCA group. SLTs showed no difference between the groups both after anesthesia induction and after protamine reversal. In ROTEM analysis, MCE contributed by platelet was reduced in the HCA group, whereas MCE contributed by fibrinogen had no difference.

Conclusion
Our study confirmed that the amount of perioperative bleeding and intraoperative transfusion were significantly higher in the HCA group. ROTEM analysis would indicate that clot firmness contributed by platelet component is reduced by HCA in cardiac surgery.
Mapping endocrine toxicity spectrum of immune checkpoint inhibitors: a disproportionality analysis using the WHO adverse drug reaction database, VigiBase
Authors: Bai Xuefeng , Lin Xiahong , Zheng Kainan , Chen Xiaoyu , Wu Xiaohong , Huang Yinqiong , Zhuang Yong 
Published: June 2020

Abstract
Purpose
Our study aimed to map endocrine toxicity spectrum of immune checkpoint inhibitors (ICIs).

Methods
We obtained data from VigiBase, between January 1, 2011 and March 6, 2019. All endocrine adverse drug reactions (ADRs) were classified by group queries according to the Medical Dictionary for Regulatory Activities. Disproportionality analysis was performed with information component (IC) and reporting odds ratio (ROR). We used IC to identify meaningful endocrinopathies associated with ICIs and ROR to compare differences between ICI subgroups of ADRs. IC025 (lower end of the 95% confidence interval of IC) is considered significant if larger than 0.

Results
In all, 6089 reports for endocrinopathies associated with ICIs were involved, with a male to female ratio of 1.5:1. The disproportionality analysis indicated significance of not only common endocrinopathies: thyroid dysfunction, hypophysitis/hypopituitarism, adrenal insufficiency, T1DM, fulminant T1DM (IC025: 4.12–6.62), but also rare endocrinopathies: hypoparathyroidism, diabetes insipidus, hypogonadism (IC025: 1.56–2.04). Increased risk of ADR reporting emerged in anti-CTLA-4 (e.g., hypophysitis/hypopituitarism, adrenal insufficiency) or in anti-PD-1/PD-L1 (e.g., thyroid dysfunction, T1DM, fulminant T1DM). In general, combination therapy (anti-CTLA-4 plus anti-PD-1/PD-L1) had a stronger association with endocrinopathies than monotherapy (ROR: 2.8, 95% CI: 2.5–3.1). Onset time of common endocrinopathies differed between different ICI therapies, typically within 12 weeks in anti-CTLA-4 monotherapy but diffusely ranging from 0 to 48 weeks in anti-PD-1 monotherapy.

Conclusions
Our study shows rising reporting frequencies of endocrinopathies caused by ICIs, especially aggravated in combination therapy. Clinicians should be early aware of latent endocrine toxicity and different onset time of endocrinopathies when implementing ICI therapies.