bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iodine nutrition status of women after 10 years of Lipiodol supplementation: a cross-sectional study in Xinjiang, China
Authors: Liu Lixiang , Liu Peng , Lin Qin , Su Xiaohui , Huang Jia , Meng Fangang , Fan Lijun , Wan Siyuan , Liu Jiwei , Cao Wanting , Zhang Ling , Shen Hongmei 
Published: October 2020

AbstractThis study examined the contribution of long-term use of Lipiodol capsules, as a supplement to iodised salt to the control of iodine deficiency disorders among women in Xinjiang of China. A total of 1220 women across Kashgar, Aksu, Turpan and Yili Prefectures were surveyed in 2017. Lipiodol capsules were administered twice yearly in Kashgar and once yearly in Aksu and Turpan, but not in Yili. Urinary iodine concentration (UIC), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody, thyroid peroxidase antibody and thyroid volume values were assessed. All the women in the four areas were in a state of non-iodine deficiency by UIC. The UIC were higher than adequate in Kashgar and Aksu (619·4 v. 278·6 μg/l). Thyroid hormone levels differed significantly in Turpan and Yili (FT3: 4·4 v. 4·6 pmol/l, FT4: 13·8 v. 14·2 pmol/l, TSH: 2·0 v. 2·7 mIU/l), but did not differ significantly in Kashgar, Aksu and Yili. The four areas did not differ significantly with regard to thyroid nodules, autoimmune thyroiditis or goitre. However, the detection rates of subclinical hypothyroidism (16·6 %) and total thyroid dysfunction (25·4 %) were higher among women in Yili. The supplementation with Lipiodol capsules had improved the iodine nutrition status of women in iodine-deficient areas of Xinjiang since 2006. To avoid negative effects of excess iodine, we suggest a gradual discontinuation of Lipiodol capsules in women with special needs based on the existing iodine nutrition level of local women.
Reliability of the NIH toolbox cognitive battery in children and adolescents: a 3-year longitudinal examination
Authors: Taylor Brittany K. , Frenzel Michaela R. , Eastman Jacob A. , Wiesman Alex I. , Wang Yu-Ping , Calhoun Vince D. , Stephen Julia M. , Wilson Tony W. 
Published: October 2020

AbstractBackgroundThe Cognitive Battery of the National Institutes of Health Toolbox (NIH-TB) is a collection of assessments that have been adapted and normed for administration across the lifespan and is increasingly used in large-scale population-level research. However, despite increasing adoption in longitudinal investigations of neurocognitive development, and growing recommendations that the Toolbox be used in clinical applications, little is known about the long-term temporal stability of the NIH-TB, particularly in youth.MethodsThe present study examined the long-term temporal reliability of the NIH-TB in a large cohort of youth (9–15 years-old) recruited across two data collection sites. Participants were invited to complete testing annually for 3 years.ResultsReliability was generally low-to-moderate, with intraclass correlation coefficients ranging between 0.31 and 0.76 for the full sample. There were multiple significant differences between sites, with one site generally exhibiting stronger temporal stability than the other.ConclusionsReliability of the NIH-TB Cognitive Battery was lower than expected given early work examining shorter test-retest intervals. Moreover, there were very few instances of tests meeting stability requirements for use in research; none of the tests exhibited adequate reliability for use in clinical applications. Reliability is paramount to establishing the validity of the tool, thus the constructs assessed by the NIH-TB may vary over time in youth. We recommend further refinement of the NIH-TB Cognitive Battery and its norming procedures for children before further adoption as a neuropsychological assessment. We also urge researchers who have already employed the NIH-TB in their studies to interpret their results with caution.
Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study
Authors: Li Gloria Hoi-Yee , Cheung Ching-Lung , Chung Albert Kar-Kin , Cheung Bernard Man-Yung , Wong Ian Chi-Kei , Fok Marcella Lei Yee , Au Philip Chun-Ming , Sham Pak-Chung 
Published: October 2020

AbstractBackgroundDepression and cardiovascular disease (CVD) are associated with each other but their relationship remains unclear. We aim to determine whether genetic predisposition to depression are causally linked to CVD [including coronary artery disease (CAD), myocardial infarction (MI), stroke and atrial fibrillation (AF)].MethodsUsing summary statistics from the largest genome-wide association studies (GWAS) or GWAS meta-analysis of depression (primary analysis: n = 500 199), broad depression (help-seeking behavior for problems with nerves, anxiety, tension or depression; secondary analysis: n = 322 580), CAD (n = 184 305), MI (n = 171 875), stroke (n = 446 696) and AF (n = 1 030 836), genetic correlation was tested between two depression phenotypes and CVD [MI, stroke and AF (not CAD as its correlation was previously confirmed)]. Causality was inferred between correlated traits by Mendelian Randomization analyses.ResultsBoth depression phenotypes were genetically correlated with MI (depression: rG = 0.169; p = 9.03 × 10−9; broad depression: rG = 0.123; p = 1 × 10−4) and AF (depression: rG = 0.112; p = 7.80 × 10−6; broad depression: rG = 0.126; p = 3.62 × 10−6). Genetically doubling the odds of depression was causally associated with increased risk of CAD (OR = 1.099; 95% CI 1.031–1.170; p = 0.004) and MI (OR = 1.146; 95% CI 1.070–1.228; p = 1.05 × 10−4). Adjustment for blood lipid levels/smoking status attenuated the causality between depression and CAD/MI. Null causal association was observed for CVD on depression. A similar pattern of results was observed in the secondary analysis for broad depression.ConclusionsGenetic predisposition to depression may have positive causal roles on CAD/MI. Genetic susceptibility to self-awareness of mood problems may be a strong causal risk factor of CAD/MI. Blood lipid levels and smoking may potentially mediate the causal pathway. Prevention and early diagnosis of depression are important in the management of CAD/MI.
Predicting depression outcomes throughout inpatient treatment using the general and specific personality disorder factors
Authors: Constantinou Matthew P. , Frueh B. Christopher , Fowler J. Christopher , Allen Jon G. , Madan Alok , Oldham John M. , Fonagy Peter 
Published: October 2020

AbstractBackgroundClinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as stylistic tendencies. The goal of this study was to clarify the unique contributions of the general and specific aspects of personality disorders to depression outcomes.MethodsPatients admitted to the Menninger Clinic, Houston, between 2012 and 2015 (N = 2352) were followed over a 6–8-week course of multimodal inpatient treatment. Personality disorder symptoms were assessed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition Axis II Personality Screening Questionnaire at admission, and depression severity was assessed using the Patient Health Questionnaire-9 every fortnight. General and specific personality disorder factors estimated with a confirmatory bifactor model were used to predict latent growth curves of depression scores in a structural equation model.ResultsThe general factor predicted higher initial depression scores but not different rates of change. By contrast, the specific borderline factor predicted slower rates of decline in depression scores, while the specific antisocial factor predicted a U shaped pattern of change.ConclusionsPersonality disorder symptoms are best represented by a general factor that reflects overall personality disorder severity, and specific factors that reflect unique personality styles. The general factor predicts overall depression severity while specific factors predict poorer prognosis which may be masked in prior studies that do not separate the two.
Between loneliness and belonging: narratives of social isolation among immigrant older adults in Canada
Authors: Koehn Sharon , Ferrer Ilyan , Brotman Shari 
Published: October 2020

AbstractResearch points to a higher risk for social isolation and loneliness among new immigrant and refugee older adults. Our article draws from a research project that explored the everyday stories of ageing among 19 diverse immigrant older adults in Canada. To capture their experiences of loneliness and social isolation, we use four illustrative cases derived from a structural approach to life-story narrative. To these we apply the intersectional lifecourse analytical lens to examine how life events, timing and structural forces shape our participants’ experiences of social isolation and loneliness. We further explore the global and linked lives of our participants as well as the categories of difference that influence their experiences along the continua of loneliness to belonging, isolation to connection. Finally, we discuss how an understanding of sources of domination and expressions of agency and resistance to these forces might lead us to solutions.
European Professors at the Cursos Latinoamericanos de Música Contemporánea: Two experiences – Piriápolis, 1974; Buenos Aires, 1977
Authors: CORRADO OMAR 
Published: October 2020

AbstractBetween 1971 and 1989, fifteen editions of the Cursos Latinoamericanos de Música Contemporánea (Latin American Contemporary Music Courses) took place alternatively in five countries of the continent. These were intensive meetings concentrated in two weeks, consisting of classes, workshops, seminars, conferences, and concerts. One of the central concerns was contemporary art music composition, although an important space was also given to performance, technologies, innovative pedagogies, popular music, and musicology. Around 150 lecturers from different countries took part in the courses, among them, about forty-five were European. On the one hand, the courses aimed at providing updated information on contemporary international musical life. On the other hand, they encouraged its critical evaluation in relation to the history, culture, and concrete practices of Latin American musicians. This article analyses exchanges between Latin American and European musicians regarding compositional techniques, theoretical perspectives, repertoires, aesthetics, and ideological positions during the 1974 and 1977 editions of the Cursos.
Pulsating white dwarfs and convection
Authors: Provencal J. L. , Montgomery M. H. , Shipman H. L. ,   The WET Team
Published: October 2020

AbstractConvection is a highly turbulent, three dimensional process that is traditionally treated using a simple, local, time independent description. Convection is one of the largest sources of theoretical uncertainty in stellar modeling. We outline recent progress in studies using pulsating white dwarfs to constrain convection and calibrate mixing length theory.
Ensemble evolutionary studies of white dwarfs in open star clusters
Authors: Williams Kurtis A 
Published: October 2020

AbstractWhite dwarfs (WDs) in open star clusters are a highly useful ensemble of stars. While numerous researchers use open cluster WDs to study the initial-final mass relation, numerous other evolutionary studies are also enabled by this sample of stars, including searches for stochastic mass loss, studies of binary star evolution, and measurements of metallicity impacts on WD formation and evolution. However, it is crucial to use astrometric data such as proper motions to remove contaminating field WDs from open cluster samples; multi-epoch ground based imaging is needed for most open cluster WDs. Also, the strongly correlated errors in the initial mass - final mass plane must be considered; we illustrate the importance of this consideration using a large open cluster WD sample and Monte Carlo techniques.
Reply to Comment by Mandel et al. on “Numerically Bounded Linguistic Probability Schemes Are Unlikely to Communicate Uncertainty Effectively”
Authors: King Andrew D. , Perkins‐Kirkpatrick Sarah E. , Wehner Michael F. , Lewis Sophie C. 
Published: October 2020

AbstractWe thank the Comment's authors for their considered critique of our paper. We respond to their main criticisms and hope that this discussion motivates further consideration of communication strategies for event attribution analyses.
Mesospheric Gravity Wave Momentum Flux Associated With a Large Thunderstorm Complex
Authors: Smith Steven M. , Setvák Martin , Beletsky Yuri , Baumgardner Jeffrey , Mendillo Michael 
Published: October 2020

AbstractWe report on estimates of the vertical flux of horizontal momentum associated with an extensive and bright mesospheric gravity wave event that occurred over the El Leoncito Observatory, Argentina (31.8°S, 69.3°W), during the night of 17–18 March 2016. Using a combination of ground‐based and space‐based data sources, we propose that the event was generated by a large and distant thunderstorm complex located to the southeast of the observation site. The nightglow, including the wave structures, was easily visible to naked eye observers, a phenomenon known as a Bright Night. Such “extreme events” illuminate the important role of upward coupling in space weather research.
Effects of Geochemical and Environmental Parameters on Abiotic Organic Chemistry Driven by Iron Hydroxide Minerals
Authors: Barge L. M. , Flores E. , VanderVelde D. G. , Weber J. M. , Baum M. M. , Castonguay A. 
Published: October 2020

AbstractGeological conditions play a significant role in prebiotic/abiotic organic chemistry, especially when reactive minerals are present. Previous studies of the prebiotic synthesis of amino acids and other products in mineral‐containing systems have shown that a diverse array of compounds can be produced, depending on the experimental conditions. However, these previous experiments have not simulated the effects of varying geochemical conditions, in which factors such as pH, iron redox state, or chemical concentrations may vary over time and space in a natural environment. In geochemical systems that contain overlapping gradients, many permutations of individual conditions could exist and affect the outcome of an organic reaction network. We investigated reactions of pyruvate and glyoxylate, two compounds that are central to the emergence of metabolism, in simulated geological gradients of redox, pH, and ammonia concentration. Our results show that the positioning of pyruvate/glyoxylate reactions in this environmental parameter space determines the organic product distribution that results. Therefore, the distribution pattern of amino acids and alpha‐hydroxy acids produced prebiotically in a system reflects the specific reaction conditions, and would be distinct at various locations in an environment depending on local geochemistry. This is significant for origin of life chemistry in which the composition and function of oligomers could be affected by the environmentally driven distribution of monomers available. Also, for astrobiology and planetary science where organic distribution patterns are sometimes considered as a possible biosignature, it is important to consider environmentally driven abiotic organic reactions that might produce similar effects.
Repulsion leads to coupled dislocation motion and extended work hardening in bcc metals
Authors: Srivastava K. , Weygand D. , Caillard D. , Gumbsch P. 
Published: October 2020

AbstractWork hardening in bcc single crystals at low homologous temperature shows a strong orientation-dependent hardening for high symmetry loading, which is not captured by classical dislocation density based models. We demonstrate here that the high activation barrier for screw dislocation glide motion in tungsten results in repulsive interactions between screw dislocations, and triggers dislocation motion at applied loading conditions where it is not expected. In situ transmission electron microscopy and atomistically informed discrete dislocation dynamics simulations confirm coupled dislocation motion and vanishing obstacle strength for repulsive screw dislocations, compatible with the kink pair mechanism of dislocation motion in the thermally activated (low temperature) regime. We implement this additional contribution to plastic strain in a modified crystal plasticity framework and show that it can explain the extended work hardening regime observed for [100] oriented tungsten single crystal. This may contribute to better understanding the increase in ductility of highly deformed bcc metals.
An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
Authors: Navarro Carmen , Lyu Jing , Katsori Anna-Maria , Caridha Rozina , Elsässer Simon J. 
Published: October 2020

AbstractNucleosome turnover concomitant with incorporation of the replication-independent histone variant H3.3 is a hallmark of regulatory regions in the animal genome. Nucleosome turnover is known to be universally linked to DNA accessibility and histone acetylation. In mouse embryonic stem cells, H3.3 is also highly enriched at interstitial heterochromatin, most prominently at intracisternal A-particle endogenous retroviral elements. Interstitial heterochromatin is established over confined domains by the TRIM28-KAP1/SETDB1 corepressor complex and has stereotypical features of repressive chromatin, such as H3K9me3 and recruitment of all HP1 isoforms. Here, we demonstrate that fast histone turnover and H3.3 incorporation is compatible with these hallmarks of heterochromatin. Further, we find that Smarcad1 chromatin remodeler evicts nucleosomes generating accessible DNA. Free DNA is repackaged via DAXX-mediated nucleosome assembly with histone variant H3.3 in this dynamic heterochromatin state. Loss of H3.3 in mouse embryonic stem cells elicits a highly specific opening of interstitial heterochromatin with minimal effects on other silent or active regions of the genome.
Toward three-dimensional hybrid inorganic/organic optoelectronics based on GaN/oCVD-PEDOT structures
Authors: Krieg Linus , Meierhofer Florian , Gorny Sascha , Leis Stefan , Splith Daniel , Zhang Zhipeng , von Wenckstern Holger , Grundmann Marius , Wang Xiaoxue , Hartmann Jana , Margenfeld Christoph , Manglano Clavero Irene , Avramescu Adrian , Schimpke Tilman , Scholz Dominik , Lugauer Hans-Jürgen , Strassburg Martin , Jungclaus Jörgen , Bornemann Steffen , Spende Hendrik , Waag Andreas , Gleason Karen K. , Voss Tobias 
Published: October 2020

AbstractThe combination of inorganic semiconductors with organic thin films promises new strategies for the realization of complex hybrid optoelectronic devices. Oxidative chemical vapor deposition (oCVD) of conductive polymers offers a flexible and scalable path towards high-quality three-dimensional inorganic/organic optoelectronic structures. Here, hole-conductive poly(3,4-ethylenedioxythiophene) (PEDOT) grown by oxidative chemical vapor deposition is used to fabricate transparent and conformal wrap-around p-type contacts on three-dimensional microLEDs with large aspect ratios, a yet unsolved challenge in three-dimensional gallium nitride technology. The electrical characteristics of two-dimensional reference structures confirm the quasi-metallic state of the polymer, show high rectification ratios, and exhibit excellent thermal and temporal stability. We analyze the electroluminescence from a three-dimensional hybrid microrod/polymer LED array and demonstrate its improved optical properties compared with a purely inorganic microrod LED. The findings highlight a way towards the fabrication of hybrid three-dimensional optoelectronics on the sub-micron scale.
A population-based cohort study of socio-demographic risk factors for COVID-19 deaths in Sweden
Authors: Drefahl Sven , Wallace Matthew , Mussino Eleonora , Aradhya Siddartha , Kolk Martin , Brandén Maria , Malmberg Bo , Andersson Gunnar 
Published: October 2020

AbstractAs global deaths from COVID-19 continue to rise, the world’s governments, institutions, and agencies are still working toward an understanding of who is most at risk of death. In this study, data on all recorded COVID-19 deaths in Sweden up to May 7, 2020 are linked to high-quality and accurate individual-level background data from administrative registers of the total population. By means of individual-level survival analysis we demonstrate that being male, having less individual income, lower education, not being married all independently predict a higher risk of death from COVID-19 and from all other causes of death. Being an immigrant from a low- or middle-income country predicts higher risk of death from COVID-19 but not for all other causes of death. The main message of this work is that the interaction of the virus causing COVID-19 and its social environment exerts an unequal burden on the most disadvantaged members of society.
Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production
Authors: Dunn Matthew J. , Fillinger Robert J. , Anderson Leah M. , Anderson Matthew Z. 
Published: October 2020

AbstractBiofilms are organized communities of microbial cells that promote persistence among bacterial and fungal species. Biofilm formation by host-associatedCandidaspecies of fungi occurs on both tissue surfaces and implanted devices, contributing to host colonization and disease. InC. albicans, biofilms are built sequentially by adherence of yeast to a surface, invasion into the substrate, the formation of aerial hyphal projections, and the secretion of extracellular matrix. Measurement of these biofilm-related phenotypes remains highly qualitative and often subjective. Here, we designed an informatics pipeline for quantifying filamentation, adhesion, and invasion ofCandidaspecies on solid agar media and utilized this approach to determine the importance of these component phenotypes toC. albicansbiofilm production. Characterization of 23C. albicansclinical isolates across three media and two temperatures revealed a wide range of phenotypic responses among isolates in any single condition. Media profoundly altered all biofilm-related phenotypes among these isolates, whereas temperature minimally impacted these traits. Importantly, the extent of biofilm formation correlated significantly with the additive score for its component phenotypes under some conditions, experimentally linking the strength of each component to biofilm mass. In addition, the response of the genome reference strain, SC5314, across these conditions was an extreme outlier compared to all other strains, suggesting it may not be representative of the species. Taken together, development of a high-throughput, unbiased approach to quantifyingCandidabiofilm-related phenotypes linked variability in these phenotypes to biofilm production and can facilitate genetic dissection of these critical processes to pathogenesis in the host.