bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are boys and girls just different? Gender differences in the Movement Assessment Battery for Children, 2nd edition (M ABC‐2) suggests that they are.
Authors: Fairbairn Natalie , Galea Claire , Wallen Margaret , Walker Karen , Hodge Antoinette , Badawi Nadia , Loughran‐Fowlds Alison 
Published: February 2020

AbstractIntroductionThe second edition of the Movement Assessment Battery for Children (M ABC‐2) is a standardised, norm referenced assessment that is frequently used by therapists to identify children with motor difficulties. The norms for the M ABC‐2 were derived from a sample of children in the United Kingdom (UK) and are combined across the age groups for boys and girls. The aims of this research were to investigate gender differences in the performance of 8‐ and 9‐year‐old Australian children and if the norms in our cohort differed from UK‐based M ABC‐2 norms.MethodsChildren aged 8 or 9 years of age who underwent major neonatal cardiac or non‐cardiac surgery and healthy controls were assessed using the M ABC‐2 as part of the Development After Infant Surgery (DAISy) study.ResultsThere were statistically significant differences in the scores for boys and girls aged 8‐ and 9‐years old on the M ABC‐2. Girls performed better than boys in manual dexterity and on total standard scores. Our control group compared to the assessment norms scored significantly poorer in manual dexterity, aiming and catching and total standard scores.ConclusionCaution should be used when interpreting the results of the M ABC‐2 for Australian 8‐ and 9‐year olds. Contemporary Australian, gender‐specific M ABC‐2 norms should be considered. Further research is required to investigate gender differences and differences in performance of Australian children compared to the assessment norms in other age groups on the M ABC‐2.
Association between state Medicaid expansion status and naloxone prescription dispensing
Authors: Sohn Minji , Talbert Jeffery C. , Delcher Chris , Hankosky Emily R. , Lofwall Michelle R. , Freeman Patricia R. 
Published: February 2020

AbstractObjectiveTo test whether Medicaid expansion is associated with (a) a greater number of naloxone prescriptions dispensed and (b) a higher proportion of naloxone prescriptions paid by Medicaid.Data Sources/Study SettingWe used the IQVIA National Prescription Audit to obtain data on per state per quarter naloxone prescription dispensing for the period 2011‐16.Study DesignIn this quasi‐experimental design study, the impact of Medicaid expansion on naloxone prescription dispensing was examined using difference‐in‐difference estimation models. State‐level covariates including pharmacy‐based naloxone laws (standing/protocol orders and direct authority to dispense naloxone), third‐party prescribing laws, opioid analgesic prescribing rates, opioid‐involved overdose death rates, and population size were controlled for in the analysis.Principal FindingsMedicaid expansion was associated with 38 additional naloxone prescriptions dispensed per state per quarter compared to nonexpansion controls, on average (P = .030). Also, Medicaid expansion resulted in an average increase of 9.86 percent in the share of naloxone prescriptions paid by Medicaid per state per quarter (P < .001).ConclusionsOur study found that Medicaid expansion increased naloxone availability. This finding suggests that it will be important to consider naloxone access when making federal‐ and state‐level decisions affecting Medicaid coverage.
Increasing Tim‐3+CD244+, Tim‐3+CD57+, and Tim‐3+PD‐1+ T cells in patients with acute myeloid leukemia
Authors: Tan Jiaxiong , Huang Shuxin , Huang Jingying , Yu Zhi , Chen Youchun , Lu Yuhong , Li Yangqiu , Chen Shaohua 
Published: February 2020

AbstractAimTo characterize the distribution of T cell immunoglobulin mucin‐domain‐containing‐3 (Tim‐3) within the exhausted T cells in patients with newly diagnosed acute myeloid leukemia (AML) and AML in complete remission.MethodsTim‐3 expression and coexpression with PD‐1, CD244, and CD57 in CD3+, CD4+, and CD8+T cells were analyzed by multicolored fluorescent flow cytometry in peripheral blood from 28 newly diagnosed, untreated AML patient and 12 cases with AML in complete remission, 23 healthy individuals served as control.ResultsIncreasing Tim‐3+CD244+ and Tim‐3+CD57+ in CD3+, CD4+, and CD8+ T cells were found in AML and AML‐CR groups in comparison with healthy controls. Similarly, increasing Tim‐3 coexpression PD‐1+ CD3+/CD4+/CD8+ T cells were found in AML group. A high tendency of PD‐1+Tim‐3+CD3+/CD4+/CD8+ T cells was detected in the AML‐M4 subtype group followed by the M2 group, and a low tendency was found in the M3 group. Moreover, Tim‐3+CD244+CD8+ T cells were found to be significantly higher in the M4 than that in M3 group. Dynamic changes of Tim‐3+ T cells in AML patients who achieved CR after chemotherapy at different time points showed that Tim‐3+ T cell subsets were evidently decreased; however, they remained at a higher level in most AML‐CR patients.ConclusionWe made a novel observation on distribution of Tim‐3+CD244+, Tim‐3+CD57+, and Tim‐3+PD‐1+ T cells in patients with AML. Chemotherapy is incapable of resolving immunosuppression in some cases with AML in CR status.
Neoadjuvant chemoradiotherapy might provide survival benefit in patients with stage IIIb/IIIc locally advanced rectal cancer: A retrospective single‐institution study with propensity score‐matched comparative analysis
Authors: Sun Xi‐yu , Cai Song‐hua , Xu Lai , Luo Dan , Qiu Hui‐zhong , Wu Bin , Lin Guo‐le , Lu Jun‐yang , Zhang Guan‐nan , Xiao Yi 
Published: February 2020

AbstractBackgroundNeoadjuvant chemoradiotherapy (NACRT) and total mesorectal excision (TME) are standard treatments of stage II/III locally advanced rectal cancer (LARC), currently. Here, we evaluated the oncological outcomes in LARC patients treated with NACRT compared to TME alone, and determined whether tumor regression grade (TRG) and pathologic response after NACRT was related to prognosis.MethodsThis is a retrospective comparison of 358 LARC patients treated with either TME alone (non‐NACRT group, n = 173) or NACRT plus TME (NACRT group, n = 185) during 2003–2013. Perioperative and oncologic outcomes, like overall survival (OS), disease‐free survival (DFS) and recurrence were compared using 1:1 propensity score matching analysis.ResultsA total of 133 patients were matched for the analysis. After a median follow‐up of 45 months (8–97 months), the 5‐year OS (NACRT vs non‐NACRT: 75.42% vs 72.76%; P = 0.594) and 5‐year DFS (NACRT vs non‐NACRT: 74.25% vs 70.13%; P = 0.224) were comparable between NACRT and non‐NACRT, whereas the 5‐year DFS rate was higher in the NACRT group when only stage IIIb/IIIc patients were considered (NACRT vs. non‐NACRT: 74.79% vs. 62.29%; P = 0.056). In the NACRT group of 185 patients, those with pCR/stage I (vs stage II/stage III disease) or TRG3/TRG4 disease (vs TRG0/TRG1/TRG2) had significantly better prognosis.ConclusionNACRT might provide survival benefit in patients with stage IIIb/IIIc locally advanced rectal cancer.
Child physical abuse, declining trend in prevalence over 10 years in Sweden
Authors: Kvist Therese , Dahllöf Göran , Svedin Carl Göran , Annerbäck Eva‐Maria 
Published: February 2020

AbstractAimTo study trends in prevalence and risk factors of child physical abuse over 10 years in Sweden.MethodsThis study analysed responses from school surveys in 2008, 2011, 2014 and 2017 in Södermanland County, Sweden with average 5125 respondents per year, 15 and 17 years old. There were identical questions on exposure to violence and risk factors including parental employment, separated parents, disability or disease, foreign background and lack of adult support. Intimate partner violence was included at three occasions. Data were analysed with bi‐ and multivariate models, and mean of accumulated risks were compared.ResultsChild physical abuse decreased significantly between 2008 and 2017. Repeated abuse decreased to a less degree than abuse once. In bivariate analyses, the share of risk factors declined for those exposed to physical abuse. In multiple analyses, it was found significant associations with exposure. There was and a dose‐relationship between numbers of accumulated risk categories and self‐reported abuse.ConclusionExposure to child physical abuse decreased substantially between 2008 and 2017. However, prevalence of abuse is still unacceptable, and the finding that prevalence of the more severe forms of CPA decreased less during the same time, draws attention to the need of ongoing efforts.
Do bipartite binary antagonistic and mutualistic networks have different responses to the taxonomic resolution of nodes?
Authors: Rodrigues Bárbara Nobrega , Boscolo Danilo 
Published: February 2020

1. Bipartite network analyses are increasingly being used to better understand mutualistic and antagonistic plant–insect interactions at the community level. As a result of taxonomic limitations, it is usually very difficult to identify all nodes of a network down to the species level and many studies leave some specimens identified as lower resolution taxa. Accordingly, we do not know how much a lower resolution taxonomic representation changes the network structure compared with a representation with all nodes at species level.2. The present study aimed to test whether insect–plant networks built using different combinations of taxonomic levels can still preserve the same basic structure of networks built only with species.3. In total, 73 bipartite published interaction networks (mutualistic and antagonistic) were selected, which were turned into binary networks and reconstructed using the nodes classified as species, genus, family or order (representing different levels of classification difficulty). The network structures were compared using their binary representations mainly using connectance, NODF (Nestedness metric based on Overlap and Decreasing Fill) and modularity.4. The mutualistic network structure was strongly linearly related to the original network structures if all nodes were grouped up to genus level. In antagonistic networks, the structure was related to the original network only if nodes were only grouped at the species level.5. The findings of the present study are especially helpful for comparative network studies, such as those assessing the effects of environmental gradients. For mutualistic networks, Citizen Science programmes can provide useful ecological indicators, even with its taxonomic limitations.
Environmental determinants of perch (Perca fluviatilis) growth in gravel pit lakes and the relative performance of simple versus complex ecological predictors
Authors: Höhne Leander , Palmer Miquel , Monk Christopher T. , Matern Sven , Nikolaus Robert , Trudeau Ashley , Arlinghaus Robert 
Published: February 2020

AbstractGrowth of fish is an important contributor to individual fitness as well as fish production. Explaining and predicting growth variation across populations is thus important from fundamental and applied perspectives, which requires knowledge about the ecological factors involved in shaping growth. To that end, we estimated environment‐dependent von Bertalanffy growth models for 13 gravel pit lake populations of Eurasian perch (Perca fluviatilis) from north‐western Germany. To identify the main drivers of perch growth, we evaluated the performance of 16 different biotic or abiotic lake variables in explaining growth variation among lakes. In addition, we compared growth predictions from the best‐performing model incorporating “complex” variables that require intensive sampling effort, with a model using only “simple”, easily measurable lake variables (e.g. shoreline development factor). The derivation of a simple model aimed at future applications in typically data‐poor inland fisheries, predicting expected growth potential from easily measurable lake variables. A model combining metabolic biomass of predators, maximum depth and shoreline development factor performed best in predicting perch growth variation across gravel pits. All three parameters in this model were positively related to perch growth. The best‐performing simple model consisted only of the shoreline development factor. Length‐at‐age predictions from both models were largely identical, highlighting the utility of shoreline development factor in approximating growth potential of perch in gravel pits similar to our study lakes. Our results can be used to inform fisheries management and restoration efforts at existing or newly excavated gravel pit lakes.
Plasma Glucose Levels Increase During Spontaneous Attacks of Migraine With and Without Aura
Authors: Zhang Ditte Georgina , Amin Faisal Mohammad , Guo Song , Vestergaard Mark B. , Hougaard Anders , Ashina Messoud 
Published: February 2020

ObjectiveTo investigate plasma glucose changes during the ictal state of migraine compared to the interictal state.BackgroundPrevious studies suggest abnormal glucose metabolism in migraine patients during and outside of attacks. It is not known if plasma glucose levels change during spontaneous migraine attacks.MethodsPlasma glucose levels were measured during and outside of spontaneous migraine attacks with and without aura. Plasma glucose values were corrected for diurnal variation of plasma glucose by subtracting the difference between the moving average (intervals of 2 hours) and overall mean from the plasma glucose values.ResultsThis was a sub‐study of a larger study conducted at Rigshospitalet Glostrup in the Capital Region of Denmark. Thirty‐one patients (24 F, 7 M, 13 with aura, 18 without aura) were included in the study. Mean time from attack onset to blood sampling was 7.6 hours. Mean pain at the time of investigation was 6 on a 0‐10 verbal rating scale. Plasma glucose was higher ictally compared to the interictal phase (interictal mean: 88.63 mg/dL, SD 11.70 mg/dL; ictal mean: 98.83 mg/dL, SD 13.16 mg/dL, difference 10.20 mg/dL, 95% CI = [4.30; 16.10]), P = .0014). The ictal increase was highest in patients investigated early during attacks and decreased linearly with time from onset of migraine (−1.57 mg/dL/hour from onset of attack, P = .020). The attack‐related increase in blood glucose was not affected by pain intensity or presence of aura symptoms.ConclusionsWe demonstrated higher plasma glucose values during spontaneous migraine attacks, independent of the presence of aura symptoms and not related to pain intensity, peaking in the early phase of attacks. Additional studies are necessary to confirm our findings and explore the possible underlying mechanisms.
Simón Bolívar and friends: Recent biographies of independence figures in Colombia and Venezuela
Authors: Racine Karen 
Published: February 2020

AbstractThe biographical genre is closely linked to the process of state building throughout Latin America and the Atlantic world. In the 19th century, statesmen and scholars produced hagiographies of their heroes' lives and viciously attacked their enemies' reputations. In a survey of recent academic biographies of independence figures in Colombia and Venezuela, several themes quickly become apparent. First, general biography remains extremely popular with both readers and writers for a broader public (including for children), but rigorous, well‐documented, scholarly studies are much fewer in number. Second, the genre remains dominated by studies of the lives of Euro‐descended creole men, most of whom were military or political actors, overwhelmingly aligned with patriot side, and resident in urban areas. Third—and directly related to the previous trend—is that most of the biographies are predicated on the concept of glory and glorious achievements. Fourth, biography remains a stubbornly national genre; in research sources and content, there appears to be little cross‐fertilization and content across countries, continents, or languages. And finally, Simón Bolívar remains a towering figure, not only because of the sheer number of biographies devoted to him specifically but also because he casts his long shadow over the life stories of virtually everyone else.
Targeting cognitive function: Development of a cognitive training intervention for diabetes
Authors: Cuevas Heather E. , Stuifbergen Alexa K. , Brown Sharon A. 
Published: February 2020

AbstractAimThe aim of this project was to develop and demonstrate the feasibility of a comprehensive cognitive training intervention to build self‐efficacy for implementation of cognitive strategies in people with diabetes.BackgroundPeople with diabetes are at greater risk than the general population for developing cognitive dysfunction. Some attention has been paid to the effect of cognitive impairments on diabetes self‐management, but even when cognitive problems have been identified, few interventions have been tailored for those with diabetes.MethodsThe intervention combines in‐person classes and home‐based online computer training. Development, in 2017, included (a) adaptation of prior established, tested interventions; (b) interviews with stakeholders; and (c) integration of course content.ResultsInformation provided by the stakeholders was used to modify an existing intervention to meet the needs of people with diabetes so that feasibility testing could occur. Despite initial difficulty with recruitment, the intervention was found to be feasible, and nineteen participants found it to be acceptable.ConclusionThis comprehensive cognitive training intervention targeting type 2 diabetes and cognitive dysfunction demonstrates that existing interventions can be adapted for use with people with diabetes.
A systematic review on randomized controlled trials: Coaching elements of digital services to support chronically ill adolescents during transition of care
Authors: Tornivuori Anna , Tuominen Outi , Salanterä Sanna , Kosola Silja 
Published: February 2020

AbstractAimsTo define digital health services that have been studied among chronically ill adolescents and to describe e‐health coaching elements that may have an impact on transition outcomes.DesignSystematic review without meta‐analysis.Data sourcesMEDLINE (Ovid), Pub Med, Scopus and CINAHL on 28 May 2018.Review methodsPeer‐reviewed articles published between January 2008‒May 2018 were reviewed following the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses statement.ResultsTwelve randomized controlled trials were included. The interventions varied significantly in duration and content. E‐coaching that included human and social support showed positive impact on transition outcomes. Digital health services incorporated into usual care provide efficient and accessible care.ConclusionE‐coaching elements enable tailoring and personalization and present a tool for supporting and motivating chronically ill adolescents during transition of care. Future research should evaluate the effectiveness of e‐coaching elements.ImpactDigital services are considered a means for increasing adolescents' motivation for self‐care and for increasing their accessibility to health care. The coaching elements in digital services consist of a theoretical basis, human support, interactive means and social support. Included interventions varied in terms of duration, dose, content and design. Our results may serve the development of digital health services for adolescents in transition. E‐coaching can be used to engage and motivate chronically ill adolescents to improve health behaviour and self‐management during transition of care.
Vagococcus salmoninarum II—qPCR, tropism and egg‐associated transmission
Authors: Standish Isaac , Leis Eric , Erickson Sara , McCann Rebekah , Puzach Corey , Katona Ryan , Lark Ellen , Bailey Jennifer , Kleman Eric , Buening Jorge , Edwards Carey , Loch Thomas , Phillips Kenneth 
Published: February 2020

AbstractVagococcus salmoninarum was identified as the causative agent of a chronic epizootic in broodstock “coaster” brook trout (Salvelinus fontinalis) at the Iron River National Fish Hatchery. The epizootic spanned more than a year, was unresponsive to multiple florfenicol treatments, and resulted in >50% mortality of the affected fish. The decision was made to cull the remaining fish during spawning, which presented an opportunity to more thoroughly examine V. salmoninarum sampling methods, organ tropism and vertical transmission. A newly developed qPCR targeting the pheS gene was used in concert with bacterial culture to show that V. salmoninarum indeed disproportionately affects females and has a tropism for female reproductive tissues. The study demonstrates that some female reproductive tissues (e.g. ovarian fluid, unfertilized eggs) are also an effective option for non‐lethal detection. Despite the widespread presence of V. salmoninarum in ovarian fluid and on egg surfaces, we found no evidence of intra‐ova transmission.
Effects of post‐packaging pasteurization process on microbial, chemical, and sensory qualities of ready‐to‐eat cured vacuum‐packed Turkey breast
Authors: Vahabi Anaraki Neda , Abbasvali Maryam , Bonyadian Mojtaba 
Published: February 2020

AbstractReady‐to‐eat (RTE) cured vacuum‐packed turkey breast was pasteurized (80°C, 5.5 min) and stored at 8°C (like supermarkets refrigerator temperature). After 42 days (current shelf life of this product), in control group (RTE cured vacuum‐packed turkey breast), the number of mesophilic, anaerobic, lactic acid bacteria, mold and yeast, coliform, and psychrotrophic increased 5.82, 6.85, 5.85, 4.75, 1.49, and 5.57 log CFU/g, respectively. However, in the pasteurized samples, the number of mesophilic, anaerobic, and lactic acid bacteria increased 1.86, 2.12, and 2.28 log CFU/g, respectively, and mold and yeast, coliform, and psychrotrophic bacteria were under the detection limit. The effects of post‐packaging pasteurization on the reduction of total mesophilic, anaerobic and lactic acid bacteria counts on Day 42 of storage was 7.04 ± 0.33, 4.73 ± 0.11, and 5.58 ± 0.11 log CFU/g, respectively. Sensory quality of treated samples was significantly better than the control's (p < .05). Post‐packaging pasteurization (PPP) significantly inhibited the reduction in the pH and the increase in TVB‐N, TBARS, titratable acidity, and drip loss (p < .05). This study shows the effectiveness of PPP on microbial, chemical, and sensory quality of cured vacuum‐packed turkey breast during cold storage.
Broad diversity of simian immunodeficiency virus infecting Chlorocebus species (African green monkey) and evidence of cross‐species infection in Papio anubis (olive baboon) in Kenya
Authors: Nyamota Richard , Owino Vincent , Murungi Edwin Kimathi , Villinger Jandouwe , Otiende Moses , Masiga Daniel , Thuita John , Lekolool Isaac , Jeneby Maamun 
Published: February 2020

AbstractBackgroundSimian immunodeficiency virus (SIV) naturally infects African non‐human primates (NHPs) and poses a threat of transmission to humans through hunting and consumption of monkeys as bushmeat. This study investigated the as of yet unknown molecular diversity of SIV in free‐ranging Chlorocebus species (African green monkeys—AGMs) and Papio anubis (olive baboons) within Mombasa, Kisumu and Naivasha urban centres in Kenya.MethodsWe collected blood samples from 124 AGMs and 65 olive baboons in situ, and detected SIV by high‐resolution melting analysis and sequencing of PCR products.ResultsSimian immunodeficiency virus prevalence was 32% in AGMs and 3% in baboons. High‐resolution melting (HRM) analysis demonstrated distinct melt profiles illustrating virus diversity confirmed by phylogenetic analysis.ConclusionsThere is persistent evolutionary diversification of SIVagm strains in its natural host, AGMs and cross‐species infection to olive baboons is occurring. Further study is required to establish pathogenesis of the diverse SIVagm variants and baboon immunological responses.