bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness of the use of hyponatraemia-inducing medications in older adults with hyponatraemia: a study of their prevalent use and association with recurrent symptomatic or severe hyponatraemia
Authors: Jun Kwanghee , Kim Yujin , Ah Young-Mi , Lee Ju-Yeun 
Published: August 2020

AbstractBackgroundCautious use or avoidance of hyponatraemia-inducing medications (HIMs) is recommended in older patients with hyponatraemia.ObjectiveTo evaluate the use of HIMs after treatment for symptomatic or severe hyponatraemia and to investigate the impact of HIMs on the recurrence of symptomatic or severe hyponatraemia in older patients.Design and settingsA cross-sectional and nested case–control study using data obtained from national insurance claims databases.MethodsThe rate of prescribing HIMs during the 3 months before and after the established index date was analysed in a cross-sectional analysis. Multivariable logistic regression was performed to investigate the association between HIM use and recurrence of symptomatic or severe hyponatraemia after adjusting for covariates in a case–control study.ResultsThe cross-sectional study included 1,072 patients treated for symptomatic or severe hyponatraemia. The proportion of patients prescribed any HIMs after hyponatraemia treatment decreased from 76.9 to 70.1%. The prescription rates significantly decreased for thiazide diuretics (from 41.9 to 20.8%) and desmopressin (from 8.6 to 4.0%), but the proportion of patients prescribed antipsychotics increased from 9.2 to 17.1%. Of 32,717 patients diagnosed with hyponatraemia, 913 (2.8%) showed recurrent hyponatraemia. After adjusting for comorbid conditions, the use of any HIMs including proton pump inhibitors [adjusted odds ratio (aOR) 1.34, 95% confidence interval (CI) 1.15–1.57] and two or more HIMs (aOR 1.48, 95% CI 1.22–1.78) especially in combination with thiazide diuretics increased the likelihood of severe hyponatraemia recurrence.ConclusionsPrevalent use of HIMs after treatment for symptomatic or severe hyponatraemia and multiple HIM use increase the risk of recurrent hyponatraemia in geriatric patients.
Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice
Authors: Bruno Clara , Sieverding Kirsten , Freischmidt Axel , Satoh Takashi , Walther Paul , Mayer B , Ludolph Albert C , Akira Shizuo , Yilmazer-Hanke Deniz , Danzer Karin M , Lobsiger Christian S , Brenner David , Weishaupt Jochen H 
Published: August 2020

Abstract
Loss-of-function mutations in TANK-binding kinase 1 cause genetic amyotrophic lateral sclerosis and frontotemporal dementia. Consistent with incomplete penetrance in humans, haploinsufficiency of TANK-binding kinase 1 did not cause motor symptoms in mice up to 7 months of age in a previous study. Ageing is the strongest risk factor for neurodegenerative diseases. Hypothesizing that age-dependent processes together with haploinsufficiency of TANK-binding kinase 1 could create a double hit situation that may trigger neurodegeneration, we examined mice with hemizygous deletion of Tbk1 (Tbk1+/− mice) and wild-type siblings up to 22 months. Compared to 4-month old mice, aged, 22-month old mice showed glial activation, deposition of motoneuronal p62 aggregates, muscular denervation and profound transcriptomic alterations in a set of 800 immune-related genes upon ageing. However, we did not observe differences regarding these measures between aged Tbk1+/− and wild-type siblings. High age did also not precipitate TAR DNA-binding protein 43 aggregation, neurodegeneration or a neurological phenotype in Tbk1+/− mice. In young Tbk1+/− mice, however, we found the CNS immune gene expression pattern shifted towards the age-dependent immune system dysregulation observed in old mice. Conclusively, ageing is not sufficient to precipitate an amyotrophic lateral sclerosis or frontotemporal dementia phenotype or spinal or cortical neurodegeneration in a model of Tbk1 haploinsufficiency. We hypothesize that the consequences of Tbk1 haploinsufficiency may be highly context-dependent and require a specific synergistic stress stimulus to be uncovered.
Effects of Age on Prestimulus Neural Activity Predictive of Successful Memory Encoding: An fMRI Study
Authors: Liu E Song , Koen Joshua D , Rugg Michael D 
Published: August 2020

AbstractPrestimulus subsequent memory effects (SMEs)—differences in neural activity preceding the onset of study items that are predictive of later memory performance—have consistently been reported in young adults. The present functional magnetic resonance imaging experiment investigated potential age-related differences in prestimulus SMEs. During study, healthy young and older participants made one of two semantic judgments on images, with the judgment signaled by a preceding cue. In test phase, participants first made an item recognition judgment and, for each item judged old, a source memory judgment. Age-invariant prestimulus SMEs were observed in left dorsomedial prefrontal cortex, left hippocampus, and right subgenual cortex. In each case, the effects reflected lower blood oxygen level dependent signal for later recognized items, regardless of source accuracy, than for unrecognized items. A similar age-invariant pattern was observed in left orbitofrontal cortex, but this effect was specific to items attracting a correct source response compared to unrecognized items. In contrast, the left angular gyrus and fusiform cortex demonstrated negative prestimulus SMEs that were exclusive to young participants. The findings indicate that age differences in prestimulus SMEs are regionally specific and suggest that prestimulus SMEs reflect multiple cognitive processes, only some of which are vulnerable to advancing age.
Imaging a Fever—Redefining the Role of 2-deoxy-2-[18F]Fluoro-D-Glucose–Positron Emission Tomography/Computed Tomography in Fever of Unknown Origin Investigations
Authors: Wright William F , Auwaerter Paul G , Dibble Elizabeth H , Rowe Steven P , Mackowiak Philip A 
Published: August 2020

Abstract
Growing evidence suggests that 2-deoxy-2-[18F]fluoro-D-glucose (18FDG)–positron emission tomography/computed tomography (PET/CT) is a useful imaging technique for the evaluation of fever of unknown origin (FUO). This imaging technique allows for accurate localization of foci of hypermetabolism based on 18FDG uptake in glycolytically active cells that may represent inflammation, infection, or neoplasia. The presence of abnormal uptake can help direct further investigation that may yield a final diagnosis. A lack of abnormal uptake can be reasonably reassuring that these conditions are not present, thereby avoiding unnecessary additional testing. Insurers have not routinely covered outpatient 18FDG-PET/CT for the indication of FUO in the United States. However, data published since 2007 suggest early use in FUO diagnostic evaluations improves diagnostic efficiency and reduces costs. Clinicians and insurers should consider 18FDG-PET/CT as a useful tool when preliminary studies are unrevealing.
Modelling the impact of structural directionality on connectome-based models of neural activity
Authors: Padmore Amelia , Nelson Martin R , Chuzhanova Nadia , Crofts Jonathan J 
Published: August 2020

AbstractUnderstanding structure--function relationships in the brain remains an important challenge in neuroscience. However, whilst structural brain networks are intrinsically directed, due to the prevalence of chemical synapses in the cortex, most studies in network neuroscience represent the brain as an undirected network. Here, we explore the role that directionality plays in shaping transition dynamics of functional brain states. Using a system of Hopfield neural elements with heterogeneous structural connectivity given by different species and parcellations (cat, Caenorhabditis elegans and two macaque networks), we investigate the effect of removing directionality of connections on brain capacity, which we quantify via its ability to store attractor states. In addition to determining large numbers of fixed-point attractor sets, we deploy the recently developed basin stability technique in order to assess the global stability of such brain states, which can be considered a proxy for network state robustness. Our study indicates that not only can directed network topology have a significant effect on the information capacity of connectome-based networks, but it can also impact significantly the domains of attraction of the aforementioned brain states. In particular, we find network modularity to be a key mechanism underlying the formation of neural activity patterns, and moreover, our results suggest that neglecting network directionality has the scope to eliminate states that correlate highly with the directed modular structure of the brain. A numerical analysis of the distribution of attractor states identified a small set of prototypical direction-dependent activity patterns that potentially constitute a `skeleton' of the non-stationary dynamics typically observed in the brain. This study thereby emphasizes the substantial role network directionality can have in shaping the brain's ability to both store and process information.
‘Non per instituir altri’? Attitudes to Rule-Following in Sixteenth-Century Poetics
Authors: Hetherington Michael 
Published: August 2020

AbstractLiterary historians tend to associate a poetics of rule-following with seventeenth-century neoclassicism, and with the sixteenth-century Italian commentators and theorists on whom the neoclassical critics drew; but thinking about the value and limitations of rules for writing is a pervasive and philosophically distinctive feature of pre-modern poetics more generally. Drawing on texts from different national literatures, on the literary theory of classical antiquity, on reflections on rule-following in non-literary early modern disciplines, and on some of the rich thinking on rules by modern philosophers, this article attempts to identify and describe some of the distinct kinds of rule-making and rule-following that constituted the discipline and practice of poetics in the sixteenth-century. To do so it focuses on three texts: Jodocus Badius Ascensius’ edition of Horace’s Ars poetica (1503), which divides the text up into ‘regulae’; Julius Caesar Scaliger’s Poetices libri septem (1561), which probes the ways in which ancient texts might function as ‘normae’ to which literary practice might be referred; and Samuel Daniels’ Musophilus (1599), which deeply if idiosyncratically meditates on the poet’s obligations and freedoms, and voices a profound scepticism about a literary practice that conforms to rules inherited from prior writers or imposed by critics.
The Mediatization of Human Rights Memory in Chile
Authors: Simón Salazar Harry 
Published: August 2020

Abstract
The current pandemic-imposed reliance on media-centered forms of civic engagement underscores the need for empirical mediatization research on the relationship between media, partisan conflict, and political culture. Drawing from critical Latin American media scholarship, mediatization theory, and Cultural Historical Activity Theory (CHAT), this article proposes a framework for comparative political communication research that centers on media practices and sociocultural change. By analyzing how a 1988 political advertising campaign in dictatorial Chile instantiated a peculiar vision of democratic transition, this article provides an examination of the disjuncture between televised representations of cheerful political reconciliation and abominable human rights abuses as the initial stage in the mediatization of Chilean human rights memory (HRM).
Percutaneous closure of an iatrogenic right ventricular perforation with an angio-seal vascular closure device: a case report
Authors: Coughlan J J , Szirt Richard , Pearson Ian , Cosgrave John 
Published: August 2020

AbstractBackgroundIatrogenic perforation of the right ventricle (RV) is a rare but recognized complication of pericardiocentesis. Treatment strategies for RV perforation include surgical repair and percutaneous closure. In this case report, we describe the use of an angio-seal vascular closure device (Terumo Interventional Systems) to seal an iatrogenic RV perforation secondary to incorrect placement of a pericardial drain.Case summaryA 55-year-old female presented with an anterior ST-elevation myocardial infarction. Coronary angiography demonstrated occlusion of the left anterior descending artery. The patient went on to have primary percutaneous coronary intervention and both the left anterior descending and D1 were wired. During kissing balloon inflation, the Sion Blue wire migrated distally in the D1 causing an Ellis type 3 wire tip perforation in the distal D1. Emergency pericardiocentesis was performed however the 8 French (8 Fr) pericardial drain was inadvertently inserted into the RV. It was decided to attempt percutaneous closure with an 8 Fr angio-seal in the catheter lab under echocardiographic and fluoroscopic guidance. Our patient did not demonstrate any recurrence of pericardial effusion on repeat echocardiography over 60 days post-procedure.DiscussionOur patient did not demonstrate any recurrence of pericardial effusion on repeat echocardiography over 60 days post-procedure. We feel that the angio-seal vascular closure device represents an effective, minimally invasive treatment for this rare but potentially catastrophic complication of pericardiocentesis. In this case, the technique spared our patient a sternotomy with its associated morbidity.
Measuring Exercise Capacity and Physical Function in Adult and Older Mice
Authors: Graber Ted G , Maroto Rosario , Fry Christopher S , Brightwell Camille R , Rasmussen Blake B 
Published: August 2020

Abstract
The inability of older adults to maintain independence is a consequence of sarcopenia and frailty. In order to identify the molecular mechanisms responsible for decreased physical function, it will be critical to utilize a small animal model. The main purpose of this study was to develop a composite Comprehensive Functional Assessment Battery (CFAB) of well-validated tests to determine physical function and exercise capacity in 3 age groups of male C57BL/6 mice (6 months old, n = 29; 24 months old, n = 24; 28+ months old, n = 28). To measure physical function in mice, we used rotarod (overall motor function), grip meter (forelimb strength), treadmill (endurance), inverted cling (strength/endurance), voluntary wheel running (volitional exercise and activity rate), and muscle performance with in vivo contractile physiology (dorsiflexor torque). We hypothesized that CFAB would be a valid means to assess the physical function of a given mouse across the life span. In addition, we proposed that CFAB could be used to determine relationships between different parameters associated with sarcopenia. We found that there was an overall age-related significant decline (p &lt; .05) in all measurements, and the CFAB score demonstrated that some individual mice (the upper quartile) retained the functional capacity of average mice 1 cohort younger. We conclude that the CFAB is a powerful, repeatable, and noninvasive tool to assess and compare physical function and assess complex motor task ability in mice, which will enable researchers to easily track performance at the individual mouse level.
Quantifying model structural uncertainty using airborne electromagnetic data
Authors: Minsley Burke J , Foks Nathan Leon , Bedrosian Paul A 
Published: August 2020

SUMMARY
The ability to quantify structural uncertainty in geological models that incorporate geophysical data is affected by two primary sources of uncertainty: geophysical parameter uncertainty and uncertainty in the relationship between geophysical parameters and geological properties of interest. Here, we introduce an open-source, trans-dimensional Bayesian Markov chain Monte Carlo (McMC) algorithm GeoBIPy—Geophysical Bayesian Inference in Python—for robust uncertainty analysis of time-domain or frequency-domain airborne electromagnetic (AEM) data. The McMC algorithm provides a robust assessment of geophysical parameter uncertainty using a trans-dimensional approach that lets the AEM data inform the level of model complexity necessary by allowing the number of model layers itself to be an unknown parameter. Additional components of the Bayesian algorithm allow the user to solve for parameters such as data errors or corrections to the measured instrument height above ground. Probability distributions for a user-specified number of lithologic classes are developed through posterior clustering of McMC-derived resistivity models. Estimates of geological model structural uncertainty are thus obtained through the joint probability of geophysical parameter uncertainty and the uncertainty in the definition of each class. Examples of the implementation of this algorithm are presented for both time-domain and frequency-domain AEM data acquired in Nebraska, USA.
Olivine-induced viscous anisotropy in fossil strike-slip mantle shear zones and associated strain localization in the crust
Authors: Mameri Lucan , Tommasi Andréa , Signorelli Javier , Hassani Riad 
Published: August 2020

SUMMARYWe propose that strain localization in plate interiors, such as linear belts of intraplate seismicity, may arise from spatial variations in viscous anisotropy produced by preferred orientation of olivine crystals (CPO or texture) inherited from previous deformation episodes in the lithospheric mantle. To quantify this effect, we model the deformation of a plate containing a fossil strike-slip mantle shear zone at different orientations relative to an imposed horizontal shortening, but no initial heterogeneity in the crust. The fossil shear zone is characterized by different orientation and intensity of the olivine CPO relatively to the surrounding mantle, which is isotropic in most simulations. The anisotropy in viscosity produced by the CPO, which remains fixed throughout the simulations, is described by an anisotropic (Hill) yield function parametrized based on second-order viscoplastic self-consistent (SO-VPSC) models. The results indicate that lateral variations in viscous anisotropy in the mantle affect the strain distribution in the entire lithosphere. Reactivation of the strike-slip mantle shear zone and strain localization in the crust above it occur for horizontal compression at 35–55° to the fossil shear plane, with a maximum at 45°. The magnitude of strain localization depends on (i) the contrast in viscous anisotropy and, hence, on the variations in CPO orientation and intensity in the mantle, (ii) the boundary conditions and (iii) the feedbacks between mantle and crustal deformation. For a strong olivine CPO, when the boundary conditions do not hinder shear parallel to the fossil mantle shear zone, strain rates within it are up to a factor 30 higher than in an isotropic surrounding mantle or up to a factor 200 when the surrounding mantle is anisotropic, which results in strain rates up to a factor 10 or up to a factor 100 higher in the crust right above the fossil shear zone. Frictional weakening in the crust faults increases strain localization in the entire lithospheric column. High strength contrasts between the mantle and the ductile crust result in less efficient mechanical coupling, with strong localization in the mantle and lower crust, but weak in the brittle upper crust. Decrease in the crust–mantle strength contrast enhances the coupling and produces more homogenous strain distribution with depth, as well as a time-dependent evolution of strain localization, which reaches a peak and decreases before attaining steady-state. Comparison of seismic anisotropy, regional stress and focal mechanism data in linear arrays of intraplate seismicity, like the New Madrid and South Armorican seismic zones, to our models' predictions corroborates that olivine CPO preserved in fossil lithospheric-scale shear zones may be key for the development of such structures.
Development of Entrustable Professional Activities for Advanced Inflammatory Bowel Disease Fellowship Training in the United States
Authors: Cohen Benjamin L , Gallinger Zane R , Ha Christina , Holubar Stefan D , Hou Jason K , Kinnucan Jami , Mahadevan Uma , Moss Alan C , Raffals Laura E , Regueiro Miguel , Szigethy Eva , Wolf Douglas , Dubinsky Marla C , Patel Anish , Shah Brijen J , Ehrlich Orna G , Hanauer Stephen B 
Published: August 2020

Abstract

Background
The level of inflammatory bowel disease (IBD) training in general gastroenterology fellowship is often insufficient to prepare trainees to deliver advanced IBD care in practice. Advanced IBD fellowships have been developed to fill this training gap, but there is no established curriculum, and significant variability exists across programs. Entrustable professional activities (EPAs) are practical and realistic objectives that define essential tasks of a specialty that physicians should master to be competent during independent practice. The American College of Gastroenterology (ACG) and Crohn’s & Colitis Foundation (Foundation) established a task force to develop and appraise EPAs for advanced IBD fellowship.

Methods
Entrustable professional activities were developed using a multistep approach in a similar manner to other specialties. Initial EPAs identified via focus groups were evaluated, critiqued, and changed using an iterative model of feedback. The final EPAs were selected after the task force conducted a 3-phase modified Delphi method consisting of 2 sequential rounds of web-based voting and an in-person consensus meeting.

Results
Ten EPAs for advanced IBD fellowship were established including detailed descriptions with the associated knowledge, skills, and attitudes for each that can serve as curricular milestones.

Conclusion
Ten EPAs describing the core work of an advanced IBD fellowship–trained physician have been established by a multisociety task force. Creating EPAs for an advanced curriculum comes with unique challenges, particularly the need to prevent duplication of prior training competencies while demonstrating the potential for unique milestones.
The frozen elephant trunk technique for acute retrograde type A aortic dissection: preliminary results
Authors: Kaneyuki Daisuke , Mogi Kenji , Watanabe Hiroyuki , Otsu Masayoshi , Sakurai Manabu , Takahara Yoshiharu 
Published: August 2020

AbstractOBJECTIVESOur goal was to determine the early and midterm outcomes after total arch replacement with the frozen elephant trunk (FET) technique compared to those of the conventional elephant trunk (ET) technique for acute retrograde type A aortic dissection.METHODSBetween 2012 and 2019, a total of 49 patients had total arch replacement for acute retrograde type A aortic dissection. Patients were divided into the conventional ET (n = 17) and FET (n = 32) groups. The false lumen status was evaluated using enhanced computed tomography (CT) 1 week postoperatively. The diameter of the downstream aorta was evaluated annually using CT. The median follow-up period was 29 months.RESULTSPreoperative data and neurological complications were not significantly different in the 2 groups. The diameter and length of the ET prosthesis were significantly larger and longer in the FET group. The overall early mortality rate was 10.2% (5/49) with no differences between the 2 groups. The mean follow-up period was significantly longer in the conventional ET group. The rates of freedom from aortic events at 3 years were significantly lower in the FET group. At the level of the distal arch, postoperative false lumen patency was significantly lower and the follow-up aortic diameter was significantly smaller in the FET group.CONCLUSIONSThe FET technique facilitates false lumen thrombosis and aortic remodelling at the distal arch level, with fewer adverse aortic events during the follow-up period with acceptable early outcomes; however, these findings are exploratory and require investigation.