bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific and technological determinants of innovation development strategy
Authors: Eliseev Vladimir Alexeevich 
Published: October 2019

The subject content of the work is domestic innovative development, the theme – scientific and technological aspects, and purpose – consideration of the determinants of the current Strategy until 2020 and prospective one – anticipated Strategy until 2030. The Methodology of work is the application of elements of system analysis (taken and expected government decisions) in the field of innovation research and technological development relating to directions, outcomes, determinants, indicators, challenges and priorities. The research is based on the general scientific method (problem statement, information-analytical generalizations, classification and analogies, analysis and synthesis, inductive-deductive approach). The results of the work consist in the formulation of scientific and technological determinants of innovative development. The application scope of the results is the strategy of innovative development until 2030.
Conclusion. The strategy of innovative development until 2020 takes into account the bases of strategic planning and scientific and technological development of the country, the selected model and the tempos of innovative development take into account the world experience and domestic characteristics, aimed at parity-adapted integration into the world economy, contribute to reducing the retardation from developed countries. Step-by-step formulation of scientific and technological determinants of innovation Strategy until 2030 can be expected from the discussed draft Program «Scientific and technological development of the Russian Federation for 2019–2030». For comparative and analytical clarification of the development model (within the framework of the Strategy until 2030), it is important to display its innovative characteristics (scientific and technical novelty, satisfaction of market demand, tradability) against the background of global trends and projected features of the «road map» of the new technological mode. At the same time, the scientific and technological determinants of innovative development will definitely remain trans-parently oriented priority areas for the development of science, technology and technology, critical technologies and technological platforms. In addition, due to the multiplicative role of attracted investments in the growth of national income and employment, it seems promising to continue to remove obstacles to the development of public-private partnerships; although, in order to increase the level of technological development of the private sector and change for the better the unsatisfactory financing of R&amp;D by business, in the foreseeable future, limited state protectionism is intended to initiate demand for innovations.
Pollution, Toxicity and Carcinogenicity of Organic Dyes and their Catalytic Bio-Remediation
Authors: Ismail Muhammad , Akhtar Kalsoom , Khan M.I. , Kamal Tahseen , Khan Murad A. , M. Asiri Abdullah , Seo Jongchul , Khan Sher B. 
Published: October 2019

:Water pollution due to waste effluents of the textile industry is seriously causing various health problems in humans. Water pollution with pathogenic bacteria, especially Escherichia coli (E. coli) and other microbes is due to the mixing of fecal material with drinking water, industrial and domestic sewage, pasture and agricultural runoff. Among the chemical pollutants, organic dyes due to toxic nature, are one of the major contaminants of industrial wastewater. Adequate sanitation services and drinking quality water would eliminate 200 million cases of diarrhea, which results in 2.1 million less deaths caused by diarrheal disease due to E. coli each year. Nanotechnology is an excellent platform as compared to conventional treatment methods of water treatment and remediation from microorganisms and organic dyes. In the current study, toxicity and carcinogenicity of the organic dyes have been studied as well as the remediation/inactivation of dyes and microorganism has been discussed. Remediation by biological, physical and chemical methods has been reviewed critically. A physical process like adsorption is cost-effective, but can’t degrade dyes. Biological methods were considered to be ecofriendly and cost-effective. Microbiological degradation of dyes is cost-effective, eco-friendly and alternative to the chemical reduction. Besides, certain enzymes especially horseradish peroxidase are used as versatile catalysts in a number of industrial processes. Moreover, this document has been prepared by gathering recent research works related to the dyes and microbial pollution elimination from water sources by using heterogeneous photocatalysts, metal nanoparticles catalysts, metal oxides and enzymes.
ZFARED: A Database of the Antioxidant Response Elements in Zebrafish
Authors: Raghunath Azhwar , Nagarajan Raju , Perumal Ekambaram 
Published: October 2019

Background:
Antioxidant Response Elements (ARE) play a key role in the expression
of Nrf2 target genes by regulating the Keap1-Nrf2-ARE pathway, which offers protection against
toxic agents and oxidative stress-induced diseases.

Objective:
To develop a database of putative AREs for all the genes in the zebrafish genome. This
database will be helpful for researchers to investigate Nrf2 regulatory mechanisms in detail.

Methods:
To facilitate researchers functionally characterize zebrafish AREs, we have developed a
database of AREs, Zebrafish Antioxidant Response Element Database (ZFARED), for all the
protein-coding genes including antioxidant and mitochondrial genes in the zebrafish genome. The
front end of the database was developed using HTML, JavaScript, and CSS and tested in different
browsers. The back end of the database was developed using Perl scripts and Perl-CGI and Perl-
DBI modules.

Results:
ZFARED is the first database on the AREs in zebrafish, which facilitates fast and
efficient searching of AREs. AREs were identified using the in-house developed Perl algorithms
and the database was developed using HTML, JavaScript, and Perl-CGI scripts. From this
database, researchers can access the AREs based on chromosome number (1 to 25 and M for
mitochondria), strand (positive or negative), ARE pattern and keywords. Users can also specify the
size of the upstream/promoter regions (5 to 30 kb) from transcription start site to access the AREs
located in those specific regions.

Conclusion:
ZFARED will be useful in the investigation of the Keap1-Nrf2-ARE pathway and its
gene regulation. ZFARED is freely available at http://zfared.buc.edu.in/.
Exploring Therapeutic Potential of Atorvastatin Against Gram-positive and Gram-negative Bacteria: In silico, In vitro and In vivo Evidences
Authors: Sethi Kamal , Singh Arti , Kumar Anoop 
Published: October 2019

Background:
The incidences of opportunistic bacterial infections have increased in the
past two decades or is expected to increase in the near future. Despite the availability of various
classes of antibiotics, bacterial infections are not handled properly.

Methods:
Thus, in the present study, we have repurposed atorvastatin against various types of
bacterial strains by using in silico, in vitro, and in vivo studies. Furthermore, a preliminary safety
study was conducted using MTT assay.

Results:
In silico study results have revealed that atorvastatin has good interaction with various
targets of bacterial cell like that of the reference ligand. However, under in vitro conditions,it was
found that atorvastatin was effective at higher concentrations (>128 μg/ml) against various bacterial
strains. Thus, further, atorvastatin was tested in combination with standard antibiotics and has
shown a synergistic effect.

Conclusion:
The MTT assay results have revealed non-cytotoxic activity of atorvastatin. In conclusion,
atorvastatin in combination with standard drugs could be developed as an antibacterial agent.
Detailed Molecular Biochemistry for Novel Therapeutic Design Against Nipah and Hendra Virus: A Systematic Review
Authors: Bhattacharya Shreya , Dhar Shreyeshi , Banerjee Arundhati , Ray Sujay 
Published: October 2019

Background:
Nipah virus (NiV) and Hendra virus (HeV) of genus Henipavirus are the deadliest
zoonotic viruses, which cause severe respiratory ailments and fatal encephalitis in humans and
other susceptible animals. The fatality rate for these infections had been alarmingly high with no approved
treatment available to date. Viral attachment and fusion with host cell membrane is essential for
viral entry and is the most essential event of viral infection. Viral attachment is mediated by interaction
of Henipavirus attachment glycoprotein (G) with the host cell receptor: Ephrin B2/B3, while viral fusion
and endocytosis are mediated by the combined action of both viral glycoprotein (G) and fusion
protein (F).

Conclusion:
This review highlights the mechanism of viral attachment, fusion and also explains the
basic mechanism and pathobiology of this infection in humans. The drugs and therapeutics used either
experimentally or clinically against NiV and HeV infection have been documented and classified in
detail. Some amino acid residues essential for the functionality of G and F proteins were also emphasized.
Therapeutic designing to target and block these residues can serve as a promising approach in
future drug development against NiV and HeV.
Protective Efficacy of Vitamin F against Acrylamide Induced Toxicity: Studies on Oxidative Stress Biomarkers
Authors: Shrivastava Sadhana , Nirala Satendra K. , Reshi Mohammad S. , Shukla Sangeeta , Sharma Anjali , Uthra Chhavi 
Published: October 2019

Introduction:Vitamin F is also known as Linoleic Acid (LA), is an Essential Fatty Acid (EFA) which is not produced in humans. It can be modified to form essential precursors such as arachidonic acid which is used to make prostaglandins, thromboxanes, and leukotrienes. It is found in abundance in several vegetable oils such as sunflower, poppy seed, safflower and corn oils. LA has shown diverse beneficial effects against diseases such as cancer, skin permeability, insulin resistance, depression and cardiovascular diseases. Acrylamide (AA) is a well known neurotoxic, carcinogenic and genotoxic compound. It is used universally in the industrial process and recently found in various food products which are cooked at a temperature above 120˚C such as potato crisps, bread, cookies and french fries. Over exposure of humans and laboratory animals to monomer AA causes damages to the central and peripheral nervous system.Objective:To investigate the therapeutic effect of linoleic acid against acrylamide toxicity.Methods:AA was given at 38.27 mg/kg dose for 10 days and therapy with different doses of linoleic acid for three days (11-13 days) to female albino rats.Results:Signs and symptoms of acrylamide toxicity occur, they include significant body weight reduction, hair loss, splaying of hindlimbs, dragging of back legs and skin irritation. A significant decline was observed in hemoglobin level and GSH, whereas significant enhancement in LPO was noted, as compared to the control group after AA exposure. The activity of acetylcholinesterase was decreased in the brain after AA administration. AA significantly reduced the superoxide dismutase and catalase activities in liver, kidney and brain but activities of serum transaminases, bilirubin, creatinine, urea and lipid profile increased in serum. Biochemical studies were also strengthened by histopathological observations.Conclusion:Study has shown that linoleic acid promotes defense against AA toxicity.
Visual Analytic Tools and Techniques in Population Health and Health Services Research: Protocol for a Scoping Review
Authors: Chishtie Jawad Ahmed , Babineau Jessica , Bielska Iwona Anna , Cepoiu-Martin Monica , Irvine Michael , Koval Andriy , Marchand Jean-Sebastien , Turcotte Luke , Jeji Tara , Jaglal Susan 
Published: October 2019

Background
Visual analytics (VA) promotes the understanding of data using visual, interactive techniques and using analytic and visual engines. The analytic engine includes machine learning and other automated techniques, whereas common visual outputs include flow maps and spatiotemporal hotspots for studying service gaps and disease distribution. The principal objective of this scoping review is to examine the state of science on VA and the various tools, strategies, and frameworks used in population health and health services research (HSR).

Objective
The purpose of this scoping review is to develop an overarching global view of established techniques, frameworks, and methods of VA in population health and HSR. The main objectives are to explore, map, and synthesize the literature related to VA in its application to the two main focus areas of health care.

Methods
We will use established scoping review methods to meet the study objective. As the use of the term visual analytics is inconsistent, one of the major challenges was operationalizing the concepts for developing the search strategy, based on the three main concepts of population health, HSR, and VA. We included peer reviewed and grey literature sources from 2005 till March 2019 in the search. Independent teams of researchers will screen the titles, abstracts and full text articles, whereas an independent researcher will arbiter conflicts. Data will be abstracted and presented using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist and explanation by two independent researchers.

Results
As of late August 2019, the scoping review is in the full-text screening stage. Data synthesis will follow and the first results are expected to be submitted for publication in December 2019. In this protocol, the methods for undertaking this scoping review are detailed. We present how we operationalized the varied concepts of population health, health services, and VA. The main results of the scoping review will synthesize peer reviewed and grey literature sources on the main methods of VA in the interrelated fields of population health and health services research from January 2005 till March 2019.

Conclusions
VA is being increasingly used and integrated with emerging technologies to support decision making using large data sets. This scoping review of the VA tools, strategies, and frameworks applied to population health and health services aims to increase awareness of this approach for uptake by decision makers working within and toward developing learning health systems globally.

International Registered Report Identifier (IRRID)
DERR1-10.2196/14019
Serum Calcification Propensity and Clinical Events in CKD
Authors: Bundy Joshua D. , Cai Xuan , Mehta Rupal C. , Scialla Julia J. , de Boer Ian H. , Hsu Chi-yuan , Go Alan S. , Dobre Mirela A. , Chen Jing , Rao Panduranga S. , Leonard Mary B. , Lash James P. , Block Geoffrey A. , Townsend Raymond R. , Feldman Harold I. , Smith Edward R. , Pasch Andreas , Isakova Tamara ,   the CRIC Study Investigators
Published: October 2019

Background and objectives
Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcification is one pathway through which cardiovascular disease risks are increased. We hypothesized that a novel measure of serum calcification propensity is associated with cardiovascular disease events, ESKD, and all-cause mortality among patients with CKD stages 2–4.

Design, setting, participants, & measurements
Among 3404 participants from the prospective, longitudinal Chronic Renal Insufficiency Cohort Study, we quantified calcification propensity as the transformation time (T50) from primary to secondary calciprotein particles, with lower T50 corresponding to higher calcification propensity. We used multivariable-adjusted Cox proportional hazards regression models to assess the associations of T50 with risks of adjudicated atherosclerotic cardiovascular disease events (myocardial infarction, stroke, and peripheral artery disease), adjudicated heart failure, ESKD, and mortality.

Results
The mean T50 was 313 (SD 79) minutes. Over an average 7.1 (SD 3.1) years of follow-up, we observed 571 atherosclerotic cardiovascular disease events, 633 heart failure events, 887 ESKD events, and 924 deaths. With adjustment for traditional cardiovascular disease risk factors, lower T50 was significantly associated with higher risk of atherosclerotic cardiovascular disease (hazard ratio [HR] per SD lower T50, 1.14; 95% confidence interval [95% CI], 1.05 to 1.25), ESKD within 3 years from baseline (HR per SD lower T50, 1.68; 95% CI, 1.52 to 1.86), and all-cause mortality (HR per SD lower T50, 1.16; 95% CI, 1.09 to 1.24), but not heart failure (HR per SD lower T50, 1.06; 95% CI, 0.97 to 1.15). After adjustment for eGFR and 24-hour urinary protein, T50 was not associated with risks of atherosclerotic cardiovascular disease, ESKD, and mortality.

Conclusions
Among patients with CKD stages 2–4, higher serum calcification propensity is associated with atherosclerotic cardiovascular disease events, ESKD, and all-cause mortality, but this association was not independent of kidney function.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_10_28_CJN04710419.mp3
LA DEPRECIACIÓN DE 2014-2018: ¿TRUMP O DÉFICITS GEMELOS?
Authors: Hernández Trillo Fausto , Luévano Kevin 
Published: October 2019

<p>Este trabajo utiliza un modelo GARCH-M para estudiar la media y varianza condicional del tipo de cambio peso-dólar. Mostró tres principales resultados: en primer lugar, que la presencia del gobierno del presidente Donald Trump no ha tenido un efecto sobre la dinámica del nivel medio del tipo de cambio; no obstante, sí afectó la volatilidad mensual del tipo de cambio durante el periodo de análisis. En segundo lugar, la dinámica de transmisión de un déficit fiscal a un déficit en cuenta corriente podría no cumplirse en México debido a que la tasa de interés no es incentivo suficiente para apreciar el tipo de cambio a través de la demanda del peso mexicano. Es decir, los incrementos en las tasas de interés no han tenido un efecto de apreciación del tipo de cambio. En tercer lugar, y desde nuestro punto de vista más importante, la depreciación del tipo de cambio fue ocasionada por la insuficiencia de financiamiento de déficits gemelos. </p><p> </p><p>THE 2014-2018 DEPRECIATION: TRUMP OR TWINS DEFICITS?</p><p><strong><br /></strong></p><p><strong>ABSTRACT</strong></p><p>This paper uses a GARCH-M model to study the exchange rate behavior during the period 2012-218. In the presence of twin deficits, and a lower level of sources of financing these, the exchange rate was the adjustment variable. The hostility of the President of the US towards Mexico increased volatility, though it did not have any effect on the exchange rate medium level.</p>
JAIME ROS BOSCH (1950-2019), In Memoriam
Authors: . . 
Published: October 2019

<p>Jaime Ros Bosch fue un destacado economista mexicano cuyo múltiple y polifacético legado se compone de: contribuciones significativas a la teoría del desarrollo económico, al diagnóstico, análisis y solución de los más acuciantes problemas contemporáneos de las economías de México y de América Latina; una activa participación en la fundación de instituciones como el Centro de Investigación y Docencia Económicas (CIDE); la edición de revistas científicas como <em>Economía Mexicana del CIDE</em> (1979-1985) y la <em>Revista de Economía Mexicana. Anuario UNAM</em> (2016-2019), que publica la Facultad de Economía de la Universidad Nacional Autónoma de México (UNAM), y colaboraciones de consultoría con varios organismos internacionales como el Banco Interamericano de Desarrollo (BID), el Banco Mundial, la Comisión Económica para América Latina y el Caribe (CEPAL), el Programa de Naciones Unidas para el Desarrollo (PNUD) y la Organización Internacional del Trabajo (OIT)...</p>
PENGARUH KOMPOSISI SERAT KELAPA TERHADAP KARAKTER DINAMIS DAN WAKTU GESEK BAHAN KOPLING GESEK KENDARAAN
Authors: Purboputro Pramuko Ilmu 
Published: October 2019

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh komposisi bahan dengan menggunakan fraksi berat serat kelapa, serbuk tembaga, fiberglass dengan resin phenolic terhadap keausan dan kekerasan specimen kampas kopling dan membandingkannya dengan kampas kopling yang sudah ada di pasaran Special Genuine Part (SGP ). Bahan yang digunakan dalam penelitian ini adalah serat kelapa, serbuk tembaga, fiberglass, dan resin phenolic. Pembuatan dilakukan dengan proses kompaksi, dengan gaya sebesar 2 ton dan ditahan selama 60 menit. Setelah mencapai holding time yang diinginkan, dies (cetakan) dimasukkan kedalam oven dan dilakukan proses sintering dengan suhu 800 C selama 40 menit dan specimen dikeluarkan dari cetakan. Setelah didapat tiga specimen kampas kopling variasi serart kelapa, serbuk tembaga, dan fiberglass lalu dilakukan proses pengujian kekerasan Brinell dengan standar ASTM F 1957-99 dan pengujian keausan dengan standar ASTM D 3702-94 kemudian dilakukan foto makro untuk melihat kepadatan dan sifat masing-masing bahan penyusun specimen kampas kopling. Hasil pengujian ini menunjukkan bahwa komposisi bahan dengan fraksi berat serat kelapa sebesar 40 %, serbuk tembaga sebesar 20 %, fiberglass 20 % dan resin phenolic 20% didapat harga kekerasan 4,098 kg/mm2, harga keausan uji kering sebesar 0,14 mm/jm dan harga keausan uji basah pengaruh oli sebesar 0,19 mm/jm. Sehingga mendekati harga kampas kopling SGP dengan harga kekerasan 3,974 kg/mm2, harga keausan uji kering sebesar 0,15 mm/jm dan harga keausan uji basah pengaruh oli sebesar 0,20 mm/jm. Waktu pengkoplingan tersingkat pada kondisi kering adalah 1,75 detik,pada variasi 3.
PENGEMBANGAN BAHAN KAMPAS REM SEPEDA MOTOR DARI KOMPOSIT SERAT BAMBU TERHADAP KETAHANAN AUS PADA KONDISI KERING DAN BASAH
Authors: Purboputro Pramuko Ilmu 
Published: October 2019

Penelitian ini untuk menemukan komposisi bahan kampas rem yang optimal non asbes, yang mempunyai karakteristik dinamik yang lebih baik. Komposisi dilakukan dari serat bambu,fiberglass, serbuk aluminium, dengan pengikat poliester. Pengujian awal yang dilakukan adalah kekerasan bahan dan keausan pada kondisi kering dan pembasahan air. Hasil yang didapat adalah kampas rem dengan komposisi Variasi 1 adalah paling keras , dengan harga kekerasan sebesar 14,47 BHN yang lebih keras dibanding produk di pasaran dengan harga kekerasan 13,7 BHN. Pengujian Keausan Ogoshi pada kondisi kering maksimal mempunyai nilai keausan yang paling rendah yaitu sebesar 0.00041mm2/kg. Untuk Pengujian Keausan Ogoshi Kondisi basah dengan air, diperoleh bahwa, bahan kampas rem dengan Variasi 1 paling rendah keausannya yaitu sebesar 0,0062 mm2/kg. Kondisi basah dengan oli, diperoleh bahwa, bahan kampas rem dengan Variasi 2 paling rendah keausannya yaitu sebesar 0,0003 mm2/kg.