bluuebunny/crossref_metadata_2025_split huggingface dataset:
3,4,5-Trihydroxybenzoic Acid Attenuates Ligature-Induced Periodontal Disease in Wistar Rats
Authors: Karatas Ozkan , Gevrek Fikret 
Published: February 2020

Background:3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an antiinflammatory agent that could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined.Methods:Thirty-two Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation. Mandibles were undergone histological evaluation. Matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1, bone morphogenetic protein (BMP)-2 expressions, tartrateresistant acid phosphatase (TRAP) positive osteoclast cells, osteoblast, and inflammatory cell counts were determined.Results:The highest alveolar bone loss was observed in the periodontitis group. Both doses of gallic acid decreased alveolar bone loss as compared to the P group. TRAP-positive osteoclast cell counts were higher in the P group, and gallic acid successfully lowered these counts. Osteoblast cells also increased in gallic acid administered groups. Inflammation in the P group was also higher than those of C, G30, and G60 groups supporting the role of gallic acid in preventing inflammation. 30 and 60 mg/kg doses of gallic acid decreased MMP-8 levels and increased TIMP-1 levels. BMP levels increased in gallic acid administered groups, similar to several osteoblasts.Conclusion:Present results revealed an anti-inflammatory effect of gallic acid, which was indicated by decreased alveolar bone loss and collagenase activity and increased osteoblastic activity.
Assessment of Admission Time Cell Blood Count (CBC) Parameters in Predicting Post-primary Percutaneous Coronary Intervention TIMI Frame Count in Patients with ST-segment Elevation Myocardial Infarction
Authors: Vakili Hossein , Khaheshi Isa , Sharifi Amirsina , Nickdoost Negin , Namazi Mohammad H. , Safi Morteza , Saadat Habibollah , Parsa Saeed A. , Akbarzadeh Mohammad A. , Naderian Mohammadreza , Yousefi Negin , Shirazi Mahin , Tabary Mohammadreza 
Published: February 2020

Objectives:In this study, we aimed to assess the value of admission time CBC parameters in predicting post-primary PCI corrected TIMI frame count.Background:Recent years have witnessed a large series of studies evaluating different laboratory variables to predict no-reflow phenomenon following primary PCI (PPCI) in patients with STEMI. However, a general agreement about the most reliable predictor of the no-reflow phenomenon is challenging and also intriguing.Methods:The current study concluded 208 consecutive patients who underwent primary PCI for ST-Elevation Myocardial Infarction (STEMI) from January 2014 to February 2016. Blood samples were obtained after taking ECG. Complete blood samples were collected and analyzed within 5 minutes from sampling. Post-PCI corrected Thrombolysis in Myocardial Infarction (TIMI) frame count was determined by one interventional cardiologist blinded to patients’ clinical data. The correlation between admission time blood parameters and post-primary PCI corrected TIMI frame count in patients with STEMI were assessed.Results:Corrected TIMI frame count was positively correlated with WBC count (R: 0.18, P-value: <0.01), neutrophil count (R: 0.34, P-value: <0.01), and platelet count (R: 0.23, P-value: <0.01) and negatively correlated with lymphocyte count (R: -0.2, P-value: <0.01). Multiple linear regression results demonstrated that corrected TIMI frame count was positively correlated with neutrophil count (P < 0·001) and platelet count (P < 0·001) and negatively correlated with lymphocyte count (p=0.004).Conclusion:High counts of WBC, neutrophil, and platelet and low count of lymphocyte may be predictors of no-reflow in STEMI patients undergoing PPCI. The clinical significance of such predictive parameters becomes clear as we consider the treatment approach in STEMI patients. Appropriate risk stratification leads to better treatment planning and allocation of resources.
Bioprocess Optimization for Enhanced Production of L-asparaginase via Two Model-Based Experimental Designs by Alkaliphilic Streptomyces fradiae NEAE-82
Authors: Soliman Hoda M. , El-Naggar Noura El-A. , El-Ewasy Sara M. 
Published: February 2020

Background:L-asparaginase is one of the most widely used chemotherapeutic agents for the treatment of a variety of lymphoproliferative disorders and particularly acute lymphoblastic leukemia. Due to increased applications of L-asparaginase in several industrial fields including food processing and medical fields, its production needs to be increased to several folds.Objective:The aim was (i) to identify the significant factors which affect L-asparaginase production by Streptomyces fradiae NEAE-82 and (ii) to achieve higher production of L-asparaginase.Methods:Sixteen assigned factors and three dummy factors were screened using Plackett-Burman experimental design to determine the most important factors for the production of L-asparaginase by Streptomyces fradiae NEAE-82.Results:L-asparagine was determined to be the most significant positive independent factor (P-value 0.0092) affecting L-asparaginase production by Streptomyces fradiae NEAE-82 followed by pH and NaCl with significant P-values of 0.0133 and 0.0272; respectively. These factors were further optimized by Box-Behnken experimental design. The optimized fermentation conditions, which resulted in the maximum L-asparagine activity of 53.572 UmL-1 are g/L: dextrose 4, L-asparagine 15, KNO3 2, MgSO4.7H2O 0.5, K2HPO4 1, FeSO4.7H2O 0.02, NaCl 0.2, ZnSO4 0.01 and inoculum size 2 %, v/v for 7 days incubation at temperature 37°C, agitation speed 100 rpm, pH 8.5.Conclusion:A total of 3.41-fold increase in the production of L-asparaginase was achieved in the medium after statistical improvement (53.572 UmL-1) as compared to the unoptimized basal medium used prior to the application of Plackett-Burman (15.704 UmL-1).
Patient Attitudes Toward Mobile Device Use by Health Care Providers in the Emergency Department: Cross-Sectional Survey
Authors: Alameddine Mohamad , Tamim Hani , Hadid Dima , Cheaito Mohamad-Ali , Makki Maha , Maatouk Hadi , Hitti Eveline 
Published: February 2020

Background
Health care provider usage of mobile devices is increasing globally; however, there is little understanding of patient perceptions on this behavior in a health care setting.

Objective
The aim of this study was to assess patients’ attitudes toward mobile device usage by health care providers in the emergency department and to identify predictors of these attitudes.

Methods
The study was carried out at the emergency department of a large academic tertiary care medical center in Lebanon. A cross-sectional survey design was adopted by administering a questionnaire to medically stable adult patients who presented to the emergency department with an emergency severity index of 3, 4, or 5 between January 2017 and March 2018. The questionnaire collected relevant patient demographic information and included questions related to their mobile device usage along with those evaluating attitudes for the use of mobile devices by health care providers with respect to six major domains: role in health care, distraction potential, impact on communication, empathy, privacy, and professionalism. The attitude toward mobile device usage by health care providers in the emergency department was the main outcome variable. A stepwise logistic regression model was used to assess the association between the outcome variable and the demographic and attitude-related independent variables.

Results
Among the 438 eligible patients, 338 patients responded to the questionnaire for a response rate of 70.0%. Overall, 313/338 (92.6%) respondents agreed that mobile devices improve health care delivery, whereas 132/338 (39.1%) respondents were opposed to their usage by health care providers in the emergency department (95% CI: 34.0-44.4). The majority (240/338, 71.0%) of patients agreed that mobile devices are a source of distraction to health care providers in the workplace. Females (odds ratio [OR]=1.67, 95% CI: 1.00-2.78) as well as all patients (OR=2.54, 95% CI 1.36-4.76) who believed that mobile devices were a source of distraction, reflecting a lack of professionalism (OR=2.77, 95% CI 1.59-4.82) and impacting the provider’s ability to relate to the patient (OR=2.93, 95% CI 1.72-4.99), were more likely to agree that mobile devices should not be used in the emergency department.

Conclusions
Patients’ negative attitude toward mobile device use in the emergency department is largely driven by patient gender (females), patient perception of the distraction potential of the devices, and their negative impact on the health care provider’s empathy and professionalism. The findings of this study shed light on the importance of encouraging stakeholders to impose a digital professionalism code of conduct for providers working in acute health care settings.
Patients’ Attitudes Toward an Online Patient Portal for Communicating Laboratory Test Results: Real-World Study Using the eHealth Impact Questionnaire
Authors: Talboom-Kamp Esther , Tossaint-Schoenmakers Rosian , Goedhart Annelijn , Versluis Anke , Kasteleyn Marise 
Published: February 2020

Background
Communicating laboratory test results online has several advantages for patients, such as improving clinical efficiency and accessibility, thereby helping patients to take an active role in managing their health.

Objective
This study aimed to investigate the experiences and self-efficacy of patients using an online patient portal that communicates laboratory test results.

Methods
We used the online-administered eHealth Impact Questionnaire to explore patients’ attitudes toward the portal. Patients visiting the portal were asked to complete the questionnaire. The subscale Information and Presentation assessed the usability of the patient portal and the subscale Motivation and Confidence to Act assessed self-efficacy to determine whether patients were motivated to act on the presented information. We used a cutoff score of 65 or greater to determine whether the portal was rated positively.

Results
The questionnaire was completed by 354 of 13,907 patients who viewed their laboratory results in the patient portal, with a response rate of 2.55%. The mean Information and Presentation score was 67.70 (SD 13.12) and the mean Motivation and Confidence to Act score was 63.59 (SD 16.22). We found a positive, significant correlation between the 2 subscales (r345=.77, P<.001).

Conclusions
Patients participating in the study rated the usability of the portal positively. However, the portal only slightly helped patients to take an active role in managing their own health. The low response rate precludes generalization of the results. Future research should examine avenues to further increase patients’ self-efficacy and study whether portal acceptability differs in subgroups. Patient portals conveying laboratory test results in understandable language seem usable and potentially provide a viable way to help patients take a more active role in managing their own health.
Combination of AHP Method and VIKOR Method For Assesing Sunday School Teacher
Authors: Waas Devi Valentino , Suprapto Suprapto 
Published: February 2020

The performance appraisal of Sunday school teacher in the Imanuel Lurang congregation aims to measure and distinguish the quality of performance achieved by Sunday school teacher and decide various policies such as giving rewards to every Sunday school teacher with the best performance, and for Sunday school teacher who have poor performance scores will be given a guiding, approach, etc. The number of criteria in determining the quality of Sunday school teacher is not an easy thing to do by manual. Then it is essential that a computerized performance appraisal-based performance app can speed up the process of progressing to be more effective and efficient. This research develops decision support systems (DSS) that is dynamic using the PHP programming language, by combining the AHP method that has been refined by the VIKOR method. The AHP method is used in determining the weight of each criterion, and the VIKOR method is used for the ranking process. Test results indicate that the system can provide a sequence of alternative Sunday school teacher that will be used as recommendations for decision makers to determine which Sunday school teachers are quality and not qualified.
Classification of Sambas Traditional Fabric “Kain Lunggi” Using Texture Feature
Authors: Siregar Alda Cendekia , Octariadi Barry Ceasar 
Published: February 2020

Traditional fabric is a cultural heritage that has to be preserved. Kain Lunggi is Sambas traditional fabric that saw a decline in its crafter. To introduce Kain Lunggi in a broader national and global society in order to preserve it, a digital image processing based system to perform Kain Lunggi pattern recognition need to be built. Feature extraction is an important part of digital image processing. The visual feature that does not represent the character of an object will affect the accuracy of a recognition system. The purposes of this research are to perform feature selection on sets of feature to determine the best feature that can increase recognition accuracy. This research conducted in several steps which are image acquisition of Kain Lunggi pattern, preprocessing to reduce image noise, feature extraction to obtain image features, and feature selection. GLCM is implemented as a feature extraction method. Feature extraction result will be used in a feature selection process using CFS (Correlation-based Feature Selection) methods. Selected features from CFS process are Angular Second Moment, Contrast, and Correlation. Selected features evaluation is conducted by calculating classification accuracy with the KNN method. Classification accuracy prior to feature extraction is 85.18% with K values K=1 ; meanwhile, the accuracy increases to 88.89% after feature selection. The highest accuracy improvement of 20.74% in KNN occurred when using K value K= 4.
The Analysis of Web Server Security For Multiple Attacks in The Tic Timor IP Network
Authors: Guterres Lilia Ervina Jeronimo , Ashari Ahmad 
Published: February 2020

The current technology is changing rapidly, with the significant growth of the internet technology, cyber threats are becoming challenging for IT professionals in the companies and organisations to guard their system. Especially when all the hacking tools and instructions are freely available on the Internet for beginners to learn how to hack such as stealing data and information. Tic Timor IP is one of the organisations involved and engaged in the data center operation. It often gets attacks from the outside networks. A network traffic monitoring system is fundamental to detect any unknown activities happening within a network. Port scanning is one of the first methods commonly used to attack a network by utilizing several free applications such as Angry IP Scan, Nmap and Low Orbit Ion Cannon (LOIC). On the other hand, the snort-based Intrusion Detection System (IDS) can be used to detect such attacks that occur within the network perimeter including on the web server. Based on the research result, snort has the ability to detect various types of attack including port scanning attacks and multiple snort rules can be accurately set to protect the network from any unknown threats.
Safety and efficacy of GP40061 compared with originator insulin glargine (Lantus
®
): a randomized open-label clinical trial
Authors: Karonova Tatiana L , Mosikian Anna A , Mayorov Alexander Y , Makarenko Igor E , Zyangirova Svetlana T , Afonkina Olena A , Belikova Tatiana M , Zalevskaya Alsu G , Khokhlov Alexander L , Drai Roman V 
Published: February 2020

Aim:
To compare safety (immunogenicity) and efficacy of GP40061 insulin glargine (GP-Gla) and Lantus
®
(Sanofi glargine, Sa-Gla) in people with diabetes mellitus.
Materials & methods:
This randomized open-label, 26-week clinical trial enrolled 180 Type 1 diabetes mellitus patients (HbA1c 6.5–12.0%), randomized 1:1 to once daily GP-Gla (n = 90) or Sa-Gla (n = 90). The primary end point was immune response at 26th week.
Results:
The frequency of immune response was similar in GP-Gla and Sa-Gla (p = 1.000). Groups were similar in terms of other safety end points. Mean HbA1c change from baseline was -0.66% for GP-Gla and -0.77% for Sa-Gla, and did not differ between groups (p = 0.326). Insulin doses, fasting plasma glucose and seven-point glucose profiles were similar between groups.
Conclusion:
GP-Gla and Sa-Gla demonstrated similar safety and efficacy.

ClinicalTrials.gov Identifier: NCT04022993
Program Keluarga Harapan dan Penurunan Angka Kematian Ibu (Studi di Provinsi Jambi dan Provinsi Kalimantan Selatan)
Authors: Susiana Sali 
Published: February 2020

The study was conducted with a qualitative approach to see how the Family Hope Program (PKH) played a role in decreasing Maternal Mortality Rate (MMR) in Jambi and South Kalimantan Provinces. Data were obtained from interviews with PKH management officials, PKH assistants and PKH recipients who were pregnant. It was found that there was no direct connection between PKH and the decline in MMR, because there was no detailed provision regarding the percentage of cash received from PKH that had to be spent to improve the nutritional quality of PKH recipients, thus influencing the quality of maternal health and reducing MMR. In addition, not all pregnant women check themselves at a minimum of 4 times during pregnancy. The two provinces do not hold special programs for pregnant women receiving PKH. Nevertheless, there were several efforts to improve the quality of health and nutrition of pregnant women from the Ministry of Health, namely through the provision of blood tablets and biscuits, as well as the implementation of the Class for Pregnant Women. To increase the effectiveness of PKH in reducing MMR, it is necessary to periodically provide assistance and monitoring to PKH recipients who were pregnant.Penelitian dilakukan dengan pendekatan kualitatif untuk melihat bagaimana peran Program Keluarga Harapan (PKH) dalam penurunan Angka Kematian Ibu (AKI) di Provinsi Jambi dan Kalimantan Selatan. Data diperoleh dari wawancara kepada pejabat pengelola PKH, pendamping PKH dan ibu hamil penerima PKH. Ditemukan bahwa tidak terdapat kaitan secara langsung antara PKH dan penurunan AKI, karena tidak ada ketentuan yang rinci mengenai persentase uang tunai yang diterima dari PKH yang harus dibelanjakan untuk meningkatkan kualitas gizi ibu hamil penerima PKH, sehingga berpengaruh pada kualitas kesehatan ibu hamil dan penurunan AKI. Selain itu, tidak semua ibu hamil memeriksakan diri minimal 4 kali selama kehamilan. Kedua provinsi tidak menyelenggarakan program khusus bagi ibu hamil penerima PKH. Meskipun demikian, ada beberapa upaya untuk meningkatkan kualitas kesehatan dan gizi ibu hamil yang menjadi program Kementerian Kesehatan, yaitu melalui pemberian tablet tambah darah dan biskuit, serta penyelenggaraan Kelas Ibu Hamil. Untuk meningkatkan efektivitas PKH dalam menurunkan AKI, perlu dilakukan pendampingan dan monitoring secara berkala kepada ibu hamil penerima PKH.
ANALYSIS OF POTENTIALS BANGUN-BANGUN (Coleus amboinicus) AND BELIMBING WULUH (Averhoa bilimbi) PLANTS, AS ANTIMICROBIAL MATERIAL
Authors: Nasution Jamilah 
Published: February 2020

Penelitian ini bertujuan untuk menganalisa senyawa apa yang memiliki daya anti mikroba yang terkandung pada tanaman bangun-bangun dan belimbing wuluh, dan membandingkan tanaman mana yang daya antrimikrobanya lebih kuat. Metode yang digunakan dalam penelitian ini adalah metode eksperimental, dengan bakteri Escherichia coli sebagai representatip dari bakteri penyebab penyakit. Data yang diperoleh dianalisis menggunaan uji ANOVA. Berdasarkan hasil penelitian, batang dan daun tanaman bangun-bangun maupun daun dan buah belimbing wuluh positif mengandung senyawa metabolit sekunder saponin yang memiliki daya antimikroba yang ditunjukkan dengan kemampuan menghambat pertumbuhan E coli. Rata-rata diameter zona hambat dari ekstrak tanaman bangun-bangun dan belimbing wuluh ≥ 21 mm, sehingga dikatagorikan punya daya antimikroba kuat. Namun zona hambat yang terbentuk belum mampu menyamai atau mengalahkan zona hambat C 25% (52.54 and 43.1), ciprofloxacin (64.41), yaitu antibiotika yang dijual dipasaran yang dijadikan kontrol positif.
Authors: Rakhmat Rakhmat 
Published: February 2020

Pesan budaya hanya ditangkap dengan penghayatan dan pemahaman murni oleh pemangku budaya sendiri. Pemilik budaya akan bisa merasakan makna karena menghayatainya dalam lingkungan bahkan sejak kecil. Pesan budaya ini kemudian diterjemahkan menjadi nilai-nilai hidup dalam masyarakat. Makna yang terkandung dalam pesan budaya Maku Gawene berisikan tentang prinsip-prinsip hidup untuk saling menyayangi, saling melindungi dalam melakukan proses komunikasi. Secara sederhana Maku Gawene dapat diartikan adanya rasa saling cinta dan dari rasa inilah yang menjadi dasar terbentuknya solidaritas sosial sekaligus perekat atas tiap perbedaan yang ada. Makna pesan budaya Magu Gawene kemudian membuat perilaku komunikasi orang Ternate menjadi inklusif dan penuh rasa cinta, sehingga bisa menerima orang lain sebagai bagian dari mereka
Pengaruh Implementasi Knowledge Management dan Stres Kerja Terhadap Kinerja Karyawan pada PT. Asaputex Jaya Kota Tegal
Authors: Sugiarto Meitoni , Waskito Jaka , Jalil Mahben 
Published: February 2020

Tujuan penelitian : 1) Untuk mengetahui adanya pengaruh knowledge management terhadap kinerja karyawan pada PT. Asaputex Jaya. 2) Untuk mengetahui adanya pengaruh stress kerja terhadap kinerja karyawan pada PT. Asaputex Jaya. 3) Untuk mengetahui adanya pengaruh antara variabel knowledge management dan stress kerja secara bersama – sama terhadap kinerja karyawan pada PT. Asaputex Jaya. Metode yang digunakan dalam penelitian ini adalah metode kausal asosiatif (causal assosiative research). Metode penelitian ini menggunakan survey membagi angket kuesioner. Sedangkan metode anaisis data yang digunakan adalah pengujian validitas dan reliabiltas, analisis korelasi rank spearman, analisis koefesien korelasi berganda, uji signifikansi korelasi berganda, analisis koefesien determinasi (R square). Berdasarkan hasil penenitian terdapat 1) terdapat pengaruh antara knowledge management terhadap kinerja karyawan hal ini dibuktikan dari hasil analisis data pada penelitian ini diperoleh koefesien korelasi (r) sebesar 0,436 dengan nilai sig = 0,000 < 0,05. 2) terdapat pengaruh antara stress kerja terhadap kinerja karyawan hal ini dibuktikan dari hasil analisis data pada penelitian ini diperoleh koefesien korelasi (r) sebesar 0,496 dengan nilai sig = 0,000 < 0,05. 3) terdapat pengaruh antara knowledge management dan stress kerja terhadap kinerja karyawan hal ini dibuktikan dari hasil analisis data pada penelitian ini diperoleh koefesien korelasi (r) sebesar 0,573 dengan nilai sig 0,000 < 0,005.