bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporators, Early Investors, and Learners: a longitudinal study of organizational adaptation during EBP implementation and sustainment
Authors: Lengnick-Hall Rebecca , Willging Cathleen E. , Hurlburt Michael S. , Aarons Gregory A. 
Published: September 2020

AbstractBackgroundThe majority of literature on evidence-based practice (EBP) adaptation focuses on changes to clinical practices without explicitly addressing how organizations must adapt to accommodate a new EBP. This study explores the process of organizational—rather than EBP—adaptation during implementation and sustainment. To the authors’ knowledge, there are no previous implementation studies that focus on organizational adaptation in this way.MethodsThis analysis utilizes a case study approach to examine longitudinal qualitative data from 17 community-based organizations (CBOs) in one state and seven county-based child welfare systems. The CBOs had sustained a child-neglect intervention EBP (SafeCare®) for 2 to 10 years. The unit of analysis was the organization, and each CBO represented a case. Organizational-level profiles were created to describe the organizational adaptation process.ResultsThree organizational-level adaptation profiles were identified as follows: incorporators (n= 7), early investors (n= 6), and learners (n= 4). Incorporators adapted by integrating SafeCare into existing operations to meet contractual or EBP fidelity requirements. Early Investors made substantial organizational adaptations during the early implementation period, then operated relatively consistently as the EBP became embedded in the organization and service system. Learners were characterized by steady and continuous attention to new ways that the organization could adapt to support the EBP.ConclusionThe profiles demonstrated that there can be multiple effective paths to EBP sustainment. Organizational adaptation was calibrated to fit a CBO’s operations (e.g., size of the program) and immediate environmental constraints (e.g., funding levels). Additionally, organizations fulfilled different functional roles in the network of entities involved in EBP implementation. Knowing organizational roles and adaptation profiles can guide implementation planning and help to structure contract designs that bridge the outer (system) and inner (organizational) contexts. Adaptation profiles can also inform the intensity of the implementation strategy tailoring process and the way that strategies are marketed to organizations.
Reverse augmentation technique in hip revision arthroplasty: a new strategy for the management of acetabular reconstruction
Authors: Götze Christian , Peterlein Christian-Dominik 
Published: September 2020

Abstract
Background
The principle of acetabular total hip revision (THR) is based on acetabular reconstruction and restoration of the center of rotation. The use of augmentation in high cranial acetabular defects combined with a cementless revision shell was studied sufficiently. This study aimed to report a case with the use of an augment inside a cementless revision shell as a reverse augmentation technique.

Methods
We describe the case of an 86-year-old female patient with a massive acetabular defect during second revision for total hip arthroplasty (THA). Two problems occurred: (1) a fixed cemented stem with a nonmodular head size of 33 mm and (2) a high acetabular defect with an elevated rotation center.

Results
With the distraction technique, allograft filling was used to reconstruct the acetabular defect. A cementless revision shell (REDAPT, Smith and Nephew) with a size of 78 mm was used to stabilize the defect. Locking screws placed cranially and distally were used to stabilize the cup for secondary osseointegration. An augment was placed inside the cup to reconstruct the rotation center. A customized polyethylene liner (outer diameter, 54 mm/inner diameter, 33 mm) was positioned below the augment in the revision cup to reconstruct the center of rotation. An 18-month postoperative X-ray analysis showed a stable construct with full secondary osseointegration.

Conclusion
This is the first report of an augment used for a reverse technique inside a cementless shell to restore the center of rotation with the use of a customized polyethylene liner. This might be a reliable option for reconstruction of the center of rotation in large cementless revision cups in acetabular Paprosky type III defects. This technical note shows the possibility of using an augment as a reverse technique in a cementless revision cup.
Analysis of two minimally invasive procedures for osteoporotic vertebral compression fractures with intravertebral cleft: a systematic review and meta-analysis
Authors: Wei Hongyu , Dong Chunke , Zhu Yuting , Ma Haoning 
Published: September 2020

Abstract
Background
A systematic review and meta-analysis to assess the pros and cons of percutaneous vertebroplasty (PVP) versus kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) with intravertebral cleft (IVC) including all available evidence from controlled trials.

Methods
Databases including Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched to identify relevant studies comparing PVP and PKP for OVCFs with IVC. The outcomes mainly included visual analog scale (VAS), Oswestry Disability Index (ODI), local kyphotic angle (LKA), rate of vertebral height (VH%), and adverse events.

Results
Nine studies enrolling 688 patients were eligible for meta-analysis. The results indicated no significant differences between the two groups in the short-and long-term VAS, ODI, LKA, or VH% (P > 0.05). Compared with PVP, PKP was associated with significantly longer operation time (P < 0.05), higher cost (P > 0.05), and more injected cement volume (P < 0.05). In terms of adverse events, PKP has a lower risk of cement leakage (P < 0.05), while with no significant difference in adjacent-level fracture rates (P > 0.05).

Conclusion
The two procedures have similar short- and long-term pain relief, functional recovery, local kyphosis correction, and vertebral height maintenance in OVCFs with IVC. PKP is superior to PVP for the injected cement volume, and lower cement leakage rate, however, with longer operation time, more fluoroscopy times, and higher cost. Further randomized controlled trials (RCTs) should be conducted to confirm these results.
A mobile app using therapeutic exercise and education for self-management in patients with hand rheumatoid arthritis: a randomized controlled trial protocol
Authors: Rodríguez-Sánchez-Laulhé Pablo , Luque-Romero Luis Gabriel , Blanquero Jesús , Suero-Pineda Alejandro , Biscarri-Carbonero Ángela , Barrero-García Francisco José , Heredia-Rizo Alberto Marcos 
Published: September 2020

AbstractBackgroundTherapeutic exercise is a safe and cost-effective approach to alleviate hand rheumatoid arthritis (RA)-related symptoms. This study aims to investigate the differences in self-management between a smartphone app (CareHand), using hand exercises and educational advices, compared with a standard approach, on hand overall function, pain intensity, stiffness, and grip and pinch strength in patients with hand RA.MethodsThe project is a prospective, longitudinal, superiority, randomized controlled trial. Fifty-eight participants with hand RA will be randomly assigned into an experimental group (CareHand app) or a control group (conventional treatment). Control intervention involves a paper sheet with exercises and recommendations, and the experimental group includes the use of a smartphone app, which provides individualized exercise programs, self-management, and educational strategies to promote adherence to treatment. Both intervention protocols will last for 3 months. The principal investigator will conduct an educational session at baseline for all participants. Primary outcome comprises the overall hand function, assessed with the Michigan Hand Outcome Questionnaire (MHQ). Secondary outcomes include self-reported functional ability with the Quick DASH questionnaire, self-reported pain intensity and morning stiffness using a Visual Analogue Scale (VAS), and hand grip and pinch strength (dynamometer). Outcome measures will be collected at baseline, and at 1 month and 3-month follow-up.DiscussionThis study will evaluate the effectiveness of a tele-rehabilitation tool, which uses exercise and self-management strategies, compared to a conventional approach, in patients with hand RA. The smartphone app will allow to monitor the patient’s status and to enhance patient-therapist communication. Some limitations may be related to the short follow-up duration and the lack of evaluation of psychosocial factors. Overall, this new way of promoting long-term effects in patients with a chronic rheumatic disease could be feasible and easy to implement in daily life clinical practice and current musculoskeletal care.Trial registrationClinicalTrials.govNCT04263974. Registered on 7 March 2020. Date of last update 15 April 2020. Ethics committee code: PI_RH_2018.
Incompletely observed: niche estimation for six frequent European horsefly species (Diptera, Tabanoidea, Tabanidae)
Authors: Dörge Dorian D. , Cunze Sarah , Klimpel Sven 
Published: September 2020

AbstractBackgroundMore than 170 species of tabanids are known in Europe, with many occurring only in limited areas or having become very rare in the last decades. They continue to spread various diseases in animals and are responsible for livestock losses in developing countries. The current monitoring and recording of horseflies is mainly conducted throughout central Europe, with varying degrees of frequency depending on the country. To the detriment of tabanid research, little cooperation exists between western European and Eurasian countries.MethodsFor these reasons, we have compiled available sources in order to generate as complete a dataset as possible of six horsefly species common in Europe. We choseHaematopota pluvialis,Chrysops relictus,C. caecutiens,Tabanus bromius,T. bovinusandT. sudeticusas ubiquitous and abundant species within Europe. The aim of this study is to estimate the distribution, land cover usage and niches of these species. We used a surface-range envelope (SRE) model in accordance with our hypothesis of an underestimated distribution based on Eurocentric monitoring regimes.ResultsOur results show that all six species have a wide range in Eurasia, have a broad climatic niche and can therefore be considered as widespread generalists. Areas with modelled habitat suitability cover the observed distribution and go far beyond these. This supports our assumption that the current state of tabanid monitoring and the recorded distribution significantly underestimates the actual distribution. Our results show that the species can withstand extreme weather and climatic conditions and can be found in areas with only a few frost-free months per year. Additionally, our results reveal that species prefer certain land-cover environments and avoid other land-cover types.ConclusionsThe SRE model is an effective tool to calculate the distribution of species that are well monitored in some areas but poorly in others. Our results support the hypothesis that the available distribution data underestimate the actual distribution of the surveyed species.
Anopheles metabolic proteins in malaria transmission, prevention and control: a review
Authors: Adedeji Eunice Oluwatobiloba , Ogunlana Olubanke Olujoke , Fatumo Segun , Beder Thomas , Ajamma Yvonne , Koenig Rainer , Adebiyi Ezekiel 
Published: September 2020

AbstractThe increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins. This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control. Highlighted are the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development. Furthermore, strategies by which these metabolic proteins can be utilized for vector control are described. Inhibitors of Anopheles metabolic proteins that are designed based on target specificity can yield insecticides with no significant toxicity to non-target species. These metabolic modulators combined with each other or with synergists, sterilants, and transmission-blocking agents in a single product, can yield potent malaria intervention strategies. These combinations can provide multiple means of controlling the vector. Also, they can help to slow down the development of insecticide resistance. Moreover, some metabolic proteins can be modulated for mosquito population replacement or suppression strategies, which will significantly help to curb malaria transmission.
Thai version of the foot function index: a cross-cultural adaptation with reliability and validity evaluation
Authors: Bovonsunthonchai Sunee , Thong-On Suthasinee , Vachalathiti Roongtiwa , Intiravoranont Warinda , Suwannarat Sarawut , Smith Richard 
Published: September 2020

Abstract
Background
The study aimed to translate the foot function index (FFI) questionnaire to Thai and to determine psychometric properties of the questionnaire among individuals with plantar foot complaints.

Methods
The Thai version of the FFI (FFI-Th) was adapted according to a forward and backward translation protocol by two independent translators and analyzed by a linguist and a committee. The FFI-Th was administered among 49 individuals with plantar foot complaints to determine internal consistency, reliability, and validity. Cronbach’s alpha and the Intraclass Correlation Coefficient (ICC3,1) were used to test the internal consistency and test-retest reliability. The Principal Component Analysis with varimax rotation method was used to test the factor structure and construct validity. Furthermore, the criterion validity was tested using Pearson’s correlation coefficient (rp) between the FFI-Th and the visual analogue pain scale (pain-VAS) as well as the EuroQol five-dimensional questionnaire (EQ-5D-5L).

Results
The FFI-Th showed good to excellent internal consistency and test-retest reliability in the total score, pain, disability, and activity limitation subscales. The Principal Component Analysis produced 4 principal factors from the FFI-Th items. Criterion validity of the FFI-Th total score showed moderate to strong correlations with pain-VAS and EQ-5D-5L, and EQ-VAS scores.

Conclusion
The FFI-Th was a reliable and valid questionnaire to assess the foot function in a Thai population.

Trial registration
NCT03161314 (08/05/2017).
Emergency demand response in edge computing
Authors: Song Zhaoyan , Zhou Ruiting , Zhao Shihan , Qin Shixin , Lui John C.S. , Li Zongpeng 
Published: September 2020

AbstractA cloudlet is a small-scale cloud datacenter deployed at the network edge to support mobile applications in proximity with low latency. While an individual cloudlet operates on moderate power, cloudlet clusters are well-suited candidates for emergency demand response (EDR) scenarios due to substantial electricity consumption and job elasticity: mobile workloads in the edge often exhibit elasticity in their execution. To efficiently carry out edge EDR via cloudlet cluster control, two fundamental problems need to be addressed: how to incentivize the participation of cloudlet clusters and how to schedule and allocate workloads in each cluster to satisfy EDR requirements. We propose a two-stage control scheme, consisting of (i) an auction mechanism to motivate clusters’ voluntary energy reduction and select participants with the minimum social cost and (ii) an online task scheduling algorithm for chosen clusters to dispatch workloads to guarantee target EDR power reduction. Using the primal-dual optimization theory, we prove that our control scheme is truthful, individually rational, runs in polynomial time, and achieves near-optimal performance. Large-scale simulation studies based on real-world data also confirm the efficiency and superiority of our scheme over state-of-the-art algorithms.
Delineation of molecular findings by whole-exome sequencing for suspected cases of paediatric-onset mitochondrial diseases in the Southern Chinese population
Authors: Tsang Mandy H.Y. , Kwong Anna K.Y. , Chan Kate L.S. , Fung Jasmine L.F. , Yu Mullin H.C. , Mak Christopher C.Y. , Yeung Kit-San , Rodenburg Richard J.T. , Smeitink Jan A.M. , Chan Rachel , Tsoi Thomas , Hui Joannie , Wong Shelia S.N , Tai Shuk-Mui , Chan Victor C.M. , Ma Che-Kwan , Fung Sharon T.H. , Wu Shun-Ping , Chak W.K. , Chung Brian H.Y. , Fung Cheuk-Wing 
Published: September 2020

Abstract
Background
Mitochondrial diseases (MDs) are a group of clinically and genetically heterogeneous disorders characterized by defects in oxidative phosphorylation. Since clinical phenotypes of MDs may be non-specific, genetic diagnosis is crucial for guiding disease management. In the current study, whole-exome sequencing (WES) was performed for our paediatric-onset MD cohort of a Southern Chinese origin, with the aim of identifying key disease-causing variants in the Chinese patients with MDs.

Methods
We recruited Chinese patients who had paediatric-onset MDs and a minimum mitochondrial disease criteria (MDC) score of 3. Patients with positive target gene or mitochondrial DNA sequencing results were excluded. WES was performed, variants with population frequency ≤ 1% were analysed for pathogenicity on the basis of the American College of Medical Genetics and Genomics guidelines.

Results
Sixty-six patients with pre-biopsy MDC scores of 3–8 were recruited. The overall diagnostic yield was 35% (23/66). Eleven patients (17%) were found to have mutations in MD-related genes, with COQ4 having the highest mutation rate owing to the Chinese-specific founder mutation (4/66, 6%). Twelve patients (12/66, 18%) had mutations in non-MD-related genes: ATP1A3 (n = 3, two were siblings), ALDH5A1, ARX, FA2H, KCNT1, LDHD, NEFL, NKX2-2, TBCK, and WAC.

Conclusions
We confirmed that the COQ4:c.370G>A, p.(Gly124Ser) variant, was a founder mutation among the Southern Chinese population. Screening for this mutation should therefore be considered while diagnosing Chinese patients suspected to have MDs. Furthermore, WES has proven to be useful in detecting variants in patients suspected to have MDs because it helps to obtain an unbiased and precise genetic diagnosis for these diseases, which are genetically heterogeneous.
Single-institution cross-sectional study to evaluate need for information and need for referral to psychooncology care in association with depression in brain tumor patients and their family caregivers
Authors: Reinert Christiane , Gerken Michael , Rathberger Katharina , Krueger Katharina , Klinkhammer-Schalke Monika , Lindberg-Scharf Patricia , Koelbl Oliver , Proescholdt Martin A. , Riemenschneider Markus J. , Pukrop Tobias , Bumes Elisabeth , Hutterer Markus , Hau Peter 
Published: September 2020

Abstract
Background
The prognosis of patients with brain tumors is widely varying. Psychooncologic need and depression are high among these patients and their family caregivers. However, the need for counselling and need for referral to psychooncology care is often underestimated.

Methods
We performed a single-institution cross-sectional study to evaluate psychooncologic need, depression and information need in both patients and their family caregivers. The Hornheider Screening Instrument (HSI) and the Patient Health Questionnaire (PHQ-9) were used to evaluate psychooncologic need and depression, and a study-specific questionnaire was developed to evaluate information need. Multivariable analyses were performed to detect correlations.

Results
A total of 444 patients and their family caregivers were approached to participate, with a survey completion rate of 35.4%. More than half of the patients and family caregivers were in need for referral to psychooncology care and 31.9% of patients suffered from clinically relevant depression. In multivariable analysis, psychooncologic need were positively associated with mild (odds ratio, OR, 7.077; 95% confidence interval, CI, 2.263–22.137; p = 0.001) or moderate to severe (OR 149.27, 95% CI 26.690–737.20; p <  0.001) depression. Patient information need was associated with depression (OR 3.007, 95% CI 1.175–7.695; p = 0.022).

Conclusions
Unmet counselling need in brain tumor patients and their family caregivers associate to high psychooncologic need and depression. Adequate information may decrease the need for referral to psychooncology care and treatment of depression in these patients. Future studies should further explore these relations to promote development of supportive structures.
An imaging and spectroscopic methodology for in situ analysis of ceiling and wall decorations in Colonial missions in Northern Mexico from XVII to XVIII centuries
Authors: Casanova-González Edgar , Maynez-Rojas Miguel Ángel , Mitrani Alejandro , Rangel-Chávez Isaac , García-Bucio María Angélica , Ruvalcaba-Sil José Luis , Muñoz-Alcócer Karla 
Published: September 2020

Abstract
Almost three hundred Spanish colonial missions—or their remains—are scattered over the vast state of Chihuahua in northern Mexico. A few of them still display painted decorations on the wood ceilings and walls. The decorated areas vary greatly, from the whole ceiling of the main aisle to just a few square meters in a lateral chapel, and so does the conservation state of the paintings. In this context, the information regarding the paintings’ composition plays a key role in the restoration and conservation processes. For the gathering of such information, we propose a combined methodology for a fast, non-destructive and non-invasive characterization of such paintings with a minimum of techniques. This methodology includes false color infrared imaging as a first approach to determine the composition of large areas of the paintings and the homogeneity of the materials used in the painted areas, followed by small area analysis by X-ray fluorescence and fiber-optics reflectance spectroscopy. This methodology was applied to characterize the elemental and molecular composition of the decorations for four missions in Chihuahua in a fast and specific manner, revealing the use of a mix of mineral and organic materials including indigo and cochineal, and detecting differences between the missions. The methodology presented here can be easily applied for the study of a wider number of missions in Chihuahua and other regions to provide outstanding information of materials, pictorial techniques and deterioration conditions.