bluuebunny/crossref_metadata_2025_split huggingface dataset:
The epigenetic implication in coronavirus infection and therapy
Authors: Atlante Sandra , Mongelli Alessia , Barbi Veronica , Martelli Fabio , Farsetti Antonella , Gaetano Carlo 
Published: October 2020

AbstractEpigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene expression through a series of reversible epigenetic modifications, such as histone methylation and acetylation, DNA/RNA methylation, chromatin remodeling, and non-coding RNAs. The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, and spread worldwide, causes it. COVID-19 severity and consequences largely depend on patient age and health status. In this review, we will summarize and comparatively analyze how viruses regulate the host epigenome. Mainly, we will be focusing on highly pathogenic respiratory RNA virus infections such as coronaviruses. In this context, epigenetic alterations might play an essential role in the onset of coronavirus disease complications. Although many therapeutic approaches are under study, more research is urgently needed to identify effective vaccine or safer chemotherapeutic drugs, including epigenetic drugs, to cope with this viral outbreak and to develop pre- and post-exposure prophylaxis against COVID-19.
Brown adipose tissue uptake of triglyceride-rich lipoprotein-derived fatty acids in diabetic or obese mice under different temperature conditions
Authors: Paulus Andreas , Drude Natascha , van Marken Lichtenbelt Wouter , Mottaghy Felix M. , Bauwens Matthias 
Published: October 2020

Abstract
Background
In vivo imaging of glucose analogue 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. However, glucose metabolism is only a part of the metabolic activity of BAT. [18F]FDG-PET has been shown in clinical trials to often fail to visualize BAT under insulin-resistant conditions associated with aging and weight gain. We employed a novel developed triglyceride-based tracer to visualize BATs metabolic activity under different temperature conditions as well as under diabetic and obese conditions in preclinical models.

Results
[18F]BDP-TG-chylomicron-like particles visualized BAT in control, streptozocin-induced diabetes and obese mice. Increased BAT tracer uptake was found in control mice acutely exposed to cold but not in cold-acclimated animals. Diabetes did not remove BAT tracer uptake, but did limit BAT tracer uptake to levels of control mice housed at 21 °C. In obese animals, BAT tracer uptake was significantly reduced, although the stimulating effect of cold exposure could still be noted.

Conclusion
BAT was visualized in control, diabetic and obese conditions. Streptozocin-induced diabetes, but not obesity, inhibited the stimulatory effect of cold exposure.
Environmental exposures and health behavior in association with mental health: a study design
Authors: Hautekiet Pauline , Nawrot Tim S. , Demarest Stefaan , Van der Heyden Johan , Van Overmeire Ilse , De Clercq Eva M. , Saenen Nelly D. 
Published: October 2020

Abstract
Background
Air pollution, green space and smoking are known to affect human health. However, less is known about their underlying biological mechanisms. One of these mechanisms could be biological aging. In this study, we explore the mediation of biomarkers of exposure and biological aging to explain the associations between environmental exposures, health behavior and mental health.

Methods
The study population of this cross-sectional study (n = 1168) is a subsample of the Belgian 2018 Health Interview Survey (BHIS). Mental health indicators including psychological and severe psychological distress, life satisfaction, vitality, eating disorders, suicidal ideation, subjective health and depressive and anxiety disorders, demographics and health behavior such as smoking are derived from the BHIS. Urine and blood samples are collected to measure respectively the biomarkers of exposure (urinary black carbon (BC) and (hydroxy)cotinine) and the biomarkers of biological aging (mitochondrial DNA content (mtDNAc) and telomere length (TL)). Recent and chronic exposure (μg/m3) to nitrogen dioxide (NO2), particulate matter ≤2.5 μm (PM2.5) and ≤ 10 μm (PM10) and BC at the participants’ residence are modelled using a high resolution spatial temporal interpolation model. Residential green space is defined in buffers of different size (50 m – 5000 m) using land cover data in ArcGIS 10 software. For the statistical analysis multivariate linear and logistic regressions as well as mediation analyses are used taking into account a priori selected covariates and confounders.

Results
As this study combined data of BHIS and laboratory analyses, not all data is available for all participants. Therefore, data analyses will be conducted on different subsets. Data on air pollution and green space exposure is available for all BHIS participants. Questions on smoking and mental health were answered by respectively 7829 and 7213 BHIS participants. For biomarker assessment, (hydroxy) cotinine, urinary BC and the biomarkers of biological aging are measured for respectively 1130, 1120 and 985 participants.

Conclusion
By use of personal markers of air pollution and smoking, as well as biological aging, we will gain knowledge about the association between environmental exposures, health behavior, and the mental health status. The results of the study can provide insights on the health of the Belgian population, making it a nationwide interesting study.
Mapping current and potential future distributions of the oak tree (Quercus aegilops) in the Kurdistan Region, Iraq
Authors: Khwarahm Nabaz R. 
Published: October 2020

AbstractBackgroundThe oak tree (Quercus aegilops) comprises ~ 70% of the oak forests in the Kurdistan Region of Iraq (KRI). Besides its ecological importance as the residence for various endemic and migratory species,Q. aegilopsforest also has socio-economic values—for example, as fodder for livestock, building material, medicine, charcoal, and firewood. In the KRI,Q. aegilopshas been degrading due to anthropogenic threats (e.g., shifting cultivation, land use/land cover changes, civil war, and inadequate forest management policy) and these threats could increase as climate changes. In the KRI and Iraq as a whole, information on current and potential future geographical distributions ofQ. aegilopsis minimal or not existent. The objectives of this study were to (i) predict the current and future habitat suitability distributions of the species in relation to environmental variables and future climate change scenarios (Representative Concentration Pathway (RCP) 2.6 2070 and RCP8.5 2070); and (ii) determine the most important environmental variables controlling the distribution of the species in the KRI. The objectives were achieved by using the MaxEnt (maximum entropy) algorithm, available records ofQ. aegilops, and environmental variables.ResultsThe model demonstrated that, under the RCP2.6 2070 and RCP8.5 2070 climate change scenarios, the distribution ranges ofQ. aegilopswould be reduced by 3.6% (1849.7 km2) and 3.16% (1627.1 km2), respectively. By contrast, the species ranges would expand by 1.5% (777.0 km2) and 1.7% (848.0 km2), respectively. The distribution of the species was mainly controlled by annual precipitation. Under future climate change scenarios, the centroid of the distribution would shift toward higher altitudes.ConclusionsThe results suggest (i) a significant suitable habitat range of the species will be lost in the KRI due to climate change by 2070 and (ii) the preference of the species for cooler areas (high altitude) with high annual precipitation. Conservation actions should focus on the mountainous areas (e.g., by establishment of national parks and protected areas) of the KRI as climate changes. These findings provide useful benchmarking guidance for the future investigation of the ecology of the oak forest, and the categorical current and potential habitat suitability maps can effectively be used to improve biodiversity conservation plans and management actions in the KRI and Iraq as a whole.
“Show this thread”: policing, disruption and mobilisation through Twitter. An analysis of UK law enforcement tweeting practices during the Covid-19 pandemic
Authors: Nikolovska Manja , Johnson Shane D. , Ekblom Paul 
Published: October 2020

AbstractCrisis and disruption are often unpredictable and can create opportunities for crime. During such times, policing may also need to meet additional challenges to handle the disruption. The use of social media by officials can be essential for crisis mitigation and crime reduction. In this paper, we study the use of Twitter for crime mitigation and reduction by UK police (and associated) agencies in the early stages of the Covid-19 pandemic. Our findings suggest that whilst most of the tweets from our sample concerned issues that were not specifically about crime, especially during the first stages of the pandemic, there was a significant increase in tweets about fraud, cybercrime and domestic abuse. There was also an increase in retweeting activity as opposed to the creation of original messages. Moreover, in terms of the impact of tweets, as measured by the rate at which they are retweeted, followers were more likely to ‘spread the word’ when the tweet was content-rich (discussed a crime specific matter and contained media), and account holders were themselves more active on Twitter. Considering the changing world we live in, criminal opportunity is likely to evolve. To help mitigate this, policy makers and researchers should consider more systematic approaches to developing social media communication strategies for the purpose of crime mitigation and reduction during disruption and change more generally. We suggest a framework for so doing.
Survey on Van Gogh’s early painting technique through the non-invasive and multi analytical study of Head of peasant
Authors: Defeyt Catherine , Marechal Dominique , Vandepitte Francisca , Strivay David 
Published: October 2020

Abstract
The strong lighting of the face against a dark background, the bold brushstroke and the model’s expressiveness that characterize Van Gogh’s Head of peasant, belonging to the Royal Museums of Fine Arts of Belgium collections, are typical features found in the peasant heads studies painted in Nuenen, in March–April 1885, in prevision of the well-known The Potato Eaters. However, this oil painting additionally testifies of Van Gogh’s early experiments in regards with the laws of colors, the flesh rendering and portraying models under artificial light. In order to collect material and technical information revealing how the painter practically handled these issues, the Brussels peasant head has been investigated in situ by complementary non-invasive imaging and analytical methods. While the identified pigments strictly reflect Van Gogh’s palette in Nuenen, relevant outcomes regarding the flesh tones composition, the rendered forceful expression of the figure, the effect of a face painted by lamplight, and the use of simultaneous color contrasts were achieved.
A survey of methods supporting cyber situational awareness in the context of smart cities
Authors: Neshenko Nataliia , Nader Christelle , Bou-Harb Elias , Furht Borko 
Published: October 2020

AbstractA modern urban infrastructure no longer operates in isolation, but instead, leverages the latest technologies to collect, process, and distribute aggregated knowledge in order to improve the quality of the provided services and promote the efficiency of resource consumption. This technological development, however, manifests in the form of new vulnerabilities and a plethora of attack vectors. In the same context, the ambiguity of ever-evolving cyber threats and their debilitating consequences introduce new barriers for decision-makers. Therefore, cyber situational awareness of smart cities emerges as a mission-critical task that requires support methods for effective and timely decision-making. In this article, we investigate the threat landscape of smart cities, survey and reveal the progress in data-driven methods for situational awareness and evaluate their effectiveness when addressing various cyber threats. We draw several potential research directions that aim at advancing cyber situational awareness in the context of smart cities.
Needs assessment and impact of COVID-19 on pharmacy professionals in 31 commonwealth countries
Authors: Ashiru-Oredope Diane , Chan Amy Hai Yan , Olaoye Omotayo , Rutter Victoria , Babar Zaheer-Ud-Din ,   The C. P. A. COVID-19 Action Team, Anderson Claire , Anderson Raymond , Halai Manjula , Matuluko Ayodeji , Nambatya Winnie , Tuck Chloe , Vadlamudi Rao , Wickens Hayley 
Published: October 2020

Abstract
Background
The declaration of COVID-19 a pandemic by the World Health Organization on 11 March 2020 marked the beginning of a global health crisis of an unprecedented nature and scale. The approach taken by countries across the world varied widely, however, the delivery of frontline healthcare was consistently recognised as being central to the pandemic response. This study aimed to identify and explore the issues currently facing pharmacy teams across Commonwealth countries during the COVID-19 pandemic. The study also evaluates pharmacy professionals’ understanding of key knowledge areas from the COVID-19 webinar hosted by the Commonwealth Pharmacists’ Association (CPA).

Method
A quantitative survey-based approach was adopted, using a 32-item questionnaire developed from the literature on pharmacy and pandemic response. The survey was hosted on Survey Monkey and pilot tested. The final survey was disseminated by CPA member organisations. A 6-item online questionnaire was sent via email to all attendees of CPA's COVID-19 webinar. Descriptive statistics on frequency distributions and percentages were used to analyse the responses. Data were analysed using Microsoft® Excel (2010).

Results
There were 545 responses from pharmacy professionals across 31/54 Commonwealth countries in Africa, Asia, the Americas, Europe and the Pacific. Majority of the respondents reported being at least somewhat worried (90%) and more than 65% were very worried or extremely about the impact of COVID-19 on them personally and professionally. Nearly two-thirds of respondents stated finding it somewhat difficult or very difficult to work effectively during the pandemic. Challenges mostly faced by pharmacy professionals working remotely included; general anxiety about the impact of COVID-19 on their lives (12%), and difficulties in communicating with their co-workers (12%). Most pharmacy professionals had not previously been actively involved in a global health emergency (82%) nor obtained training on global/public health emergency preparedness (62%). Between 45 and 97% of the COVID-19 webinar attendees provided the correct answers to post-webinar questions, suggesting some improvement in knowledge.

Conclusion
Our study confirms pharmacy professionals’ concerns about practice during a pandemic and provides preliminary data on the challenges and learning needs of the profession. The CPA has since acted on these findings, providing ongoing opportunities to develop and refine resources for the profession as the pandemic evolves. Pharmacy professionals have also demonstrated improved knowledge on the management of COVID-19 and resources available for professionals.
Bootstrapping Swarm and observatory data to generate candidates for the DGRF and IGRF-13
Authors: Pavón-Carrasco F. Javier , Marsal Santiago , Torta J. Miquel , Catalán Manuel , Martín-Hernández Fátima , Tordesillas J. Manuel 
Published: October 2020

AbstractAs posted by the Working Group V of the International Association of Geomagnetism and Aeronomy (IAGA), the 13th generation of the International Geomagnetic Reference Field (IGRF) has been released at the end of 2019. Following IAGA recommendations, in this work we present a candidate model for the IGRF-13, for which we have used the available Swarm satellite and geomagnetic observatory ground data for the last year. In order to provide the IGRF-13 candidate, we have extrapolated the Gauss coefficients of the main field and its secular variation to January 1st, 2020. In addition, we have generated a Definitive Geomagnetic Reference Field model for 2015.0 using the same modelling approach, but focussed on a 1-year time window of data centred on 2015.0. To jointly model both satellite and ground data, we have followed the classical protocols and data filters applied in geomagnetic field modelling. Novelty arrives from the application of bootstrap analysis to solve issues related to the inhomogeneity of the spatial and temporal data distributions. This new approach allows the estimation of not only the Gauss coefficients, but also their uncertainties.
Sequential modelling of the Earth’s core magnetic field
Authors: Ropp Guillaume , Lesur Vincent , Baerenzung Julien , Holschneider Matthias 
Published: October 2020

AbstractWe describe a new, original approach to the modelling of the Earth’s magnetic field. The overall objective of this study is to reliably render fast variations of the core field and its secular variation. This method combines a sequential modelling approach, a Kalman filter, and a correlation-based modelling step. Sources that most significantly contribute to the field measured at the surface of the Earth are modelled. Their separation is based on strong prior information on their spatial and temporal behaviours. We obtain a time series of model distributions which display behaviours similar to those of recent models based on more classic approaches, particularly at large temporal and spatial scales. Interesting new features and periodicities are visible in our models at smaller time and spatial scales. An important aspect of our method is to yield reliable error bars for all model parameters. These errors, however, are only as reliable as the description of the different sources and the prior information used are realistic. Finally, we used a slightly different version of our method to produce candidate models for the thirteenth edition of the International Geomagnetic Reference Field.
The CHAOS-7 geomagnetic field model and observed changes in the South Atlantic Anomaly
Authors: Finlay Christopher C. , Kloss Clemens , Olsen Nils , Hammer Magnus D. , Tøffner-Clausen Lars , Grayver Alexander , Kuvshinov Alexey 
Published: October 2020

AbstractWe present the CHAOS-7 model of the time-dependent near-Earth geomagnetic field between 1999 and 2020 based on magnetic field observations collected by the low-Earth orbit satellites Swarm, CryoSat-2, CHAMP, SAC-C and Ørsted, and on annual differences of monthly means of ground observatory measurements. The CHAOS-7 model consists of a time-dependent internal field up to spherical harmonic degree 20, a static internal field which merges to the LCS-1 lithospheric field model above degree 25, a model of the magnetospheric field and its induced counterpart, estimates of Euler angles describing the alignment of satellite vector magnetometers, and magnetometer calibration parameters for CryoSat-2. Only data from dark regions satisfying strict geomagnetic quiet-time criteria (including conditions on IMF $$B_z$$

B
z

and $$B_y$$

B
y

at all latitudes) were used in the field estimation. Model parameters were estimated using an iteratively reweighted regularized least-squares procedure; regularization of the time-dependent internal field was relaxed at high spherical harmonic degree compared with previous versions of the CHAOS model. We use CHAOS-7 to investigate recent changes in the geomagnetic field, studying the evolution of the South Atlantic weak field anomaly and rapid field changes in the Pacific region since 2014. At Earth’s surface a secondary minimum of the South Atlantic Anomaly is now evident to the south west of Africa. Green’s functions relating the core–mantle boundary radial field to the surface intensity show this feature is connected with the movement and evolution of a reversed flux feature under South Africa. The continuing growth in size and weakening of the main anomaly is linked to the westward motion and gathering of reversed flux under South America. In the Pacific region at Earth’s surface between 2015 and 2018 a sign change has occurred in the second time derivative (acceleration) of the radial component of the field. This acceleration change took the form of a localized, east–west oriented, dipole. It was clearly recorded on ground, for example at the magnetic observatory at Honolulu, and was seen in Swarm observations over an extended region in the central and western Pacific. Downward continuing to the core–mantle boundary, we find this event originated in field acceleration changes at low latitudes beneath the central and western Pacific in 2017.
The impact of human capital efficiency on Latin American mutual funds during Covid-19 outbreak
Authors: Mirza Nawazish , Hasnaoui Jamila Abaidi , Naqvi Bushra , Rizvi Syed Kumail Abbas 
Published: October 2020

AbstractThe mutual funds’ returns, inter alia, are dependent on fund managers’ performance. This makes human capital efficiency very central for consistent risk-adjusted performance. The persistence in performance becomes more critical during periods of high turbulence, like the one we are experiencing amidst the outbreak of Covid-19. In this research, we attempt to evaluate the performance of equity funds in massively impacted Latin American countries. These equity funds, with 95% of their investment in the infected region, are ranked as per their human capital efficiency using 2019 as the base year. Our findings demonstrate that funds with higher human capital efficiency significantly outperform their counterparts that rank lower on human capital efficiency. These findings remained consistent for the sub-periods that we specify to map the evolution of Covid-19. We conclude that equity funds should enhance their human capital efficiency to endure resilience amid macroeconomic shocks.
Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection
Authors: Yu Changhao , Zhou Dong , Jiang Weijia , Mu Jie 
Published: October 2020

AbstractSeizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus (HIV) infection or diagnosed with immune deficiency syndrome, with higher incidence and prevalence than in the general population. Generalized seizures are the most common type in the patients. Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients, but a variety of pathogenic factors can also be found in these patients, such as metabolic perturbation and drug-drug interactions. The diagnostic criteria for seizures in these patients are the same as those in the general population. As HIV patients with seizures need to take both antivirals and antiepileptic drugs, the risk of drug-drug interactions is greatly increased, and the side effects of drugs may also become more prominent. At present, most experience in antiepileptic drug usage has come from the general population, and there is still a lack of guidance of antiepileptic drug use in special groups such as the HIV-infected people. Unlike the old-generation drugs that involve metabolisms through CYP450, the first-line antiepileptic drugs usually bypass CYP450, thus having less drug-drug interactions. In this review, we summarize the recent research progress on the above-mentioned widely discussed topics and make a prospect on future research direction.