bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a low‐cost food color monitoring system
Authors: Jain Ankit , Pradhan Bikash K. , Mahapatra Paresh , Ray Sirsendu S. , Chakravarty Sumit , Pal Kunal 
Published: October 2020

AbstractThe colorimetric analysis of food has gained much popularity in the last few decades. The present study reports the development of a low‐cost food color quality testing and process monitoring system. The proposed device consists of a hardware and a software (Color Magic) combination, which may allow the hardware to be used either for quality testing or process monitoring applications. In the quality‐testing mode, the software captures the image of the food products through the imaging system. Subsequently, the software processes the acquired image and computes color parameters in RGB (red, green, blue), CIELAB, and HSI (hue, saturation, intensity) color spaces. The software also synthesizes and displays the perceived color information in the display panel. The datalog of the sample color information can be sent to the user. Further, a separate software (Color Process), which is installed in a central server, was developed to implement a wireless star network topology for multi‐node process monitoring. The “Color Process” software allows users to acquire color information from multiple hardware. The software monitors the Hue from all the devices. It alerts the user via email if the Hue is beyond the range in any of the nodes. Finally, the device was tested for quality testing and process monitoring applications using colored placards and apple slices. The implementation of the wireless sensor network (WSN) in designing the multi‐node process monitoring makes the proposed device a unique system. This further would allow the device to be used for process monitoring at multiple remote locations.
Biopharmaceutical Characteristics of Nifurtimox Tablets for Age‐ and Body Weight‐Adjusted Dosing in Patients With Chagas Disease
Authors: Stass Heino , Feleder Ethel , Garcia‐Bournissen Facundo , Nagelschmitz Johannes , Weimann Boris , Yerino Gustavo , Altcheh Jaime 
Published: October 2020

AbstractTreatment of Chagas disease with nifurtimox requires age‐ and body weight‐adjusted dosing, resulting in complex dosing instructions. Appropriate formulations are needed for precise and compliant dosing, especially in pediatric patients. We characterized the biopharmaceutical features of a standard nifurtimox 120‐mg tablet and a 30‐mg tablet developed to improve dose accuracy. Two open‐label, randomized crossover studies were conducted in adult outpatients with Chagas disease. One study investigated whether 4 × 30‐mg tablets and 1 × 120‐mg tablet were bioequivalent and whether tablets can be administered as an aqueous slurry without affecting bioavailability. The second study investigated the effect of a high‐calorie/high‐fat diet versus fasting on the absorption of nifurtimox after a single 4 × 30‐mg dose. Interventions were equivalent if the 90% confidence interval (CI) of their least‐squares (LS) mean ratios for both AUC0‐tlast and Cmax were in the range of 80%‐125%. The 4 × 30‐mg and 1 × 120‐mg tablet doses were bioequivalent (AUC0‐tlast: LS mean ratio, 104.7%; 90%CI, 99.1%‐110.7%; Cmax: LS mean ratio, 101.7%; 90%CI, 89.4%‐115.6%; n = 24). Exposure when giving the 4 × 30‐mg dose as a slurry or as tablets was comparable, with an AUC0‐tlast ratio of 93.2% (84.2%‐103.1%; n = 12) and a slightly decreased Cmax ratio for the slurry of 76.5% (68.8%‐85.1%). Food improved the bioavailability of nifurtimox substantially (AUC0‐tlast ratiofed/fasted, 172%; 90%CI, 154%‐192%; Cmax ratiofed/fasted, 168%; 90%CI, 150%‐187%). The data indicate that the 30‐ and 120‐mg tablets are suitable for dosing adult and pediatric patients accurately; nifurtimox should be administered under fed conditions.
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Authors: Wilbraham Darren , Biglan Kevin M. , Svensson Kjell A. , Tsai Max , Kielbasa William 
Published: October 2020

AbstractActivation of the brain dopamine D1 receptor has attracted attention because of its promising role in neuropsychiatric diseases. Although efforts to develop D1 agonists have been challenging, a positive allosteric modulator (PAM), represents an attractive approach with potential better drug‐like properties. Phase 1 single‐ascending‐dose (SAD; NCT03616795) and multiple‐ascending‐dose (MAD; NCT02562768) studies with the D1PAM mevidalen (LY3154207) were conducted with healthy subjects. There were no treatment‐related serious adverse events (AEs) in these studies. In the SAD study, 25‐200 mg administered orally showed dose‐proportional pharmacokinetics (PK) and acute dose‐related increases in systolic blood pressure (SBP) and diastolic blood pressure DBP) and pulse rate at doses ≥ 75 mg. AE related to central activation were seen at doses ≥ 75 mg. At 25 and 75 mg, central penetration of mevidalen was confirmed by measurement of mevidalen in cerebrospinal fluid. In the MAD study, once‐daily doses of mevidalen at 15‐150 mg for 14 days showed dose‐proportional PK. Acute dose‐dependent increases in SBP, DBP, and PR were observed on initial administration, but with repeated dosing the effects diminished and returned toward baseline levels. Overall, these findings support further investigation of mevidalen as a potential treatment for a range of neuropsychiatric disorders.
Design Strategies of Transition‐Metal Phosphate and Phosphonate Electrocatalysts for Energy‐Related Reactions
Authors: Zhao Hui , Yuan Zhong‐Yong 
Published: October 2020

AbstractThe key challenge to developing renewable energy conversion and storage devices lies in the exploration and rational engineering of cost‐effective and highly efficient electrocatalysts for various energy‐related electrochemical reactions. Transition‐metal phosphates and phosphonates have shown remarkable performances for these reactions based on their unique physicochemical properties. Compared with transition‐metal oxides, phosphate groups in transition‐metal phosphates and phosphonates show flexible coordination with diverse orientations, making them an ideal platform for designing active electrocatalysts. Although numerous efforts have been spent on the development of transition‐metal phosphate and phosphonate electrocatalysts, some urgent issues, such as low intrinsic catalytic efficiency and low electronic conductivity, have to be resolved in accordance with their applications. In this Review, we focus on the design strategies of highly efficient transition‐metal phosphate and phosphonate electrocatalysts, with special emphasis on the tuning of transition‐metal‐center coordination environment, optimization of electronic structures, increase of catalytically active site densities, and construction of heterostructures. Guided by these strategies, recently developed transition‐metal phosphate and phosphonate materials have exhibited excellent activity, selectivity, and stability for various energy‐related electrocatalytic reactions, showing great potential for replacing noble‐metal‐based catalysts in next‐generation advanced energy techniques. The existing challenges and prospects regarding these materials are also presented.
No evidence for differential sociosexual behavior and space use in the color morphs of the European common wall lizard (Podarcis muralis)
Authors: Abalos Javier , Pérez i de Lanuza Guillem , Bartolomé Alicia , Liehrmann Océane , Laakkonen Hanna , Aubret Fabien , Uller Tobias , Carazo Pau , Font Enrique 
Published: October 2020

AbstractExplaining the evolutionary origin and maintenance of color polymorphisms is a major challenge in evolutionary biology. Such polymorphisms are commonly thought to reflect the existence of alternative behavioral or life‐history strategies under negative frequency‐dependent selection. The European common wall lizard Podarcis muralis exhibits a striking ventral color polymorphism that has been intensely studied and is often assumed to reflect alternative reproductive strategies, similar to the iconic “rock–paper–scissors” system described in the North American lizard Uta stansburiana. However, available studies so far have ignored central aspects in the behavioral ecology of this species that are crucial to assess the existence of alternative reproductive strategies. Here, we try to fill this gap by studying the social behavior, space use, and reproductive performance of lizards showing different color morphs, both in a free‐ranging population from the eastern Pyrenees and in ten experimental mesocosm enclosures. In the natural population, we found no differences between morphs in site fidelity, space use, or male–female spatial overlap. Likewise, color morph was irrelevant to sociosexual behavior, space use, and reproductive success within experimental enclosures. Our results contradict the commonly held hypothesis that P. muralis morphs reflect alternative behavioral strategies, and suggest that we should instead turn our attention to alternative functional explanations.
Cu2O/CuO Electrocatalyst for Electrochemical Reduction of Carbon Dioxide to Methanol
Authors: Roy Animesh , Jadhav Harsharaj S. , Gil Seo Jeong 
Published: October 2020

AbstractHerein, we report the controlled and direct fabrication of Cu2O/CuO thin film on the conductive nickel foam using electrodeposition route for the electrochemical reduction of carbon dioxide (CO2) to methanol. The electrocatalytic reduction was performed in CO2 saturated aqueous solution consisting of KHCO3, pyridine and HCl at room temperature. CO2 reduction was carried out at a constant potential of −1.3 V for 120 min to study the electrochemical performance of the prepared electrocatalysts. Cu2O/CuO shows better electrocatalytic activity with highest current density of 46 mA/cm2. The prepared catalyst can be an efficient and selective electrode for the production of methanol.
Influences of trailing edge split flap on the aerodynamic performance of vertical axis wind turbine
Authors: Zhang Lijun , Gu Jiawei , Hu Kuoliang , Zhu Huaibao , Miao Junjie , Li Xiang , Ma Dongchen , Mi Yuxia , Wang Zhiwei 
Published: October 2020

AbstractTo improve the performance of a 3.5 kW small H‐type vertical axis wind turbine (VAWT) with the airfoil of NACA0015, a design method for installing split flaps at the trailing edge of a blade is proposed. By solving the two‐dimensional URANS equations, the simulation of VAWTs is carried out. The influences of the length (10% c‐30% c), arrangement positions (90% c‐70% c), and deflection angles (10°‐30°) of the split flaps on the performance of VAWT are determined by orthogonal design when Reynolds number is 2 × 105 and 1 < TSR < 3. In accordance with the influence degrees of these parameters and adopting the maximum wind energy utilization ratio CPmax and the maximum efficient operating range Δλmax as research objectives, the optimum flap length is determined as 22% c, the optimum deflection angle is 10°, and the optimum arrangement position is 92% c. Further studies show that the CPmax is increased by 5.8% and its Δλmax is increased by 25.9% after installing split flaps. Meanwhile, split flaps can change the Kutta‐Joukowsky trailing edge boundary condition, which increases the flow circulation around the airfoil. Also, split flaps can increase the positive pressure difference in the upwind area and reduce the negative pressure difference in the downwind area, which significantly improves the aerodynamic performance of VAWTs.
On the use of Glimm‐like schemes for transport equations on multidimensional domain
Authors: Hurisse Olivier 
Published: October 2020

AbstractThis article is dedicated to a numerical method based on Glimm's idea and applied to the specific problem of advection of an indicator function. The numerical scheme relies on a fractional step approach for which: the first step is performed using any classical finite‐volume scheme, and the second step sharpens the approximated solution issued from the first step. This second step is based on a random choice as proposed in the original idea of Glimm. In order to assess the capabilities of this approach, several test cases have been investigated including convergence studies with respect to the mesh‐size. The method proposed in this article is very easy to implement, even for multiprocessor computations, and it naturally extends to multidimensional domains. Several numerical test cases, including both one‐ and two‐dimensional domains, have been considered in order to examine its behavior in terms of robustness, accuracy, and convergence rate.
Impact of bitcoin futures on the informational efficiency of bitcoin spot market
Authors: Shynkevich Andrei 
Published: October 2020

AbstractThis study examines the informational efficiency of the bitcoin spot market by evaluating the predictive power of mechanical trading rules designed to exploit price continuation. Significant return predictability is found until the introduction of bitcoin futures in December 2017. The forecasting ability of trend‐chasing trading rules declines dramatically afterwards. Although evidence suggests that the introduction of bitcoin futures has increased the informational efficiency of the bitcoin spot market, no signs of improvement in informational efficiency are found in ethereum, the second‐largest cryptocurrency—following the introduction of bitcoin futures.
Still in search of strategic human resource management? A review and suggestions for future research with China as an example
Authors: Cooke Fang Lee , Xiao Mengtian , Chen Yang 
Published: October 2020

AbstractStrategic human resource management (SHRM) has been an important strand of research in the HRM field for over three decades, and has attracted heated debates in recent years. One main critique of the state of SHRM research is its increasing detachment from HRM practice, in the pursuit of more theoretical rigor and methodological sophistication. Our review article has two main tasks. First, we review SHRM research published in two leading HRM journals—Human Resource Management and Human Resource Management Journal—in the light of the criticisms on SHRM research and use this as a backdrop of our second task. Second, we critically examine SHRM research conducted in the Chinese context by drawing on a systematic review on extant literature. In doing so, we draw on a wider range of HRM journals such as Human Resource Management Review, The International Journal of Human Resource Management, and so forth. We find that while the trend of psychologization in SHRM research is gathering pace, the range of theoretical perspectives mobilized to inform the studies is actually expanding. We call for SHRM research to be more contextualized and more practical phenomenon‐driven SHRM research. We indicate several avenues for future research, using China as an example.
Computation of radiative Marangoni (thermocapillary) magnetohydrodynamic convection in a Cu‐water based nanofluid flow from a disk in porous media: Smart coating simulation
Authors: Shamshuddin MD. , Mishra S. R. , Bég O. Anwar , Bég Tasveer A. , Ali Kadir 
Published: October 2020

AbstractWith emerging applications for smart and intelligent coating systems in energy, there has been increasing activity in researching magnetic nanomaterial coating flows. Surface tension features significantly in such regimes, and in the presence of heat transfer, Marangoni (thermocapillary) convection arises. Motivated by elaborating deeper the intrinsic transport phenomena in such systems, in this paper, a mathematical model is developed for steady radiative heat transfer and Marangoni magnetohydrodynamic flow of a Cu‐water nanofluid influencing a strong magnetic field through a porous disk. The semianalytical adomain decomposition method is employed to find the solution of flow governing equations, which are reduced into ordinary differential equation form via the Von Karman similarity transformation. Validation with a generalized differential quadrature algorithm is included. The response in dimensionless velocity, temperature, wall heat transfer rate and shear stress is investigated for various values of the control parameters. Temperature is reduced with increasing Marangoni parameter, whereas the flow is accelerated. With increasing permeability parameter, the temperatures are elevated. Increasing radiative flux boosts temperatures further from the disk surface. Increasing magnetic parameter strongly dampens the boundary layer flow and elevates the temperatures, also eliminating temperature oscillations at lower magnetic field strengths.
Does ownership structure affect the optimal capital structure? A PSTR model for China
Authors: Hu Xiaojian , Yao Gang , Zhou Taiyun 
Published: October 2020

AbstractIn the context of Chinese enterprises' privatization reforms, the relationships between ownership structure and optimal capital structure and between ownership structure and firm performance are worth attention. Using data on listed companies in China, this article uses the panel smooth transfer regression (PSTR) model and multiple regression models to test the nonlinear relationship between capital structure and firm performance. The optimal capital structure is calculated using the partial correlation function of the PSTR model, and the ownership structure–optimal capital structure relationship is analysed. This research found that (a) the effect of the debt‐to‐asset ratio on firm performance shows a nonlinear relationship with sudden changes in characteristics, and a debt‐to‐asset ratio interval exists that can significantly improve firm performance; (b) under the premise of the effect of ownership checks and balances, an increase in ownership concentration can improve the optimal capital structure; thus, enterprises can achieve effective operations with higher debt; (c) the promotion effect of ownership concentration on firm performance varies depending on a company's debt‐to‐asset ratio; and (d) different industries have different optimal capital structures. The raw materials industry has a high optimal capital structure. A series of robustness tests verify the robustness of these conclusions. This research enriches the theoretical interpretation of the optimal capital structure and provides new insights into the relationship between ownership structure and firm performance. The conclusions drawn by this article are helpful to enterprises making corresponding financial decisions and the government in formulating corresponding capital market systems.
Sources of economic slowdown: A simultaneous equations approach
Authors: Zhao Daping , Anwar Sajid , Alexander W. Robert J. 
Published: October 2020

AbstractWe explore the potential sources of slowdown in growth in a theoretical macroeconomic framework, from which we develop an empirical model consisting of a system of equations for the growth rate of GDP and the consumption share of GDP. Having estimated the basic model, we perform an extreme bounds analysis with a range of control variables as a robustness check on the results. In a sample of middle‐income countries, an increase in the consumption ratio appears to be negatively associated with economic growth; foreign direct investment is found to be significantly associated with both economic growth and the consumption ratio. On considering sub‐samples of Asian and Latin American countries, we find, in the Asian economies, that there is an inverted U‐shaped relationship between the consumption ratio and economic growth while, in the Latin American economies, there is an inverted U‐shaped relationship between the consumption ratio and growth but a U‐shaped relationship between the government spending ratio and economic growth. In both sub‐samples, the investment ratio is positively associated with growth.
Usefulness of robot‐assisted radical prostatectomy in a patient with oligometastatic castration‐resistant prostate cancer
Authors: Koie Takuya , Hagiwara Noriyasu , Yamada Toru , Kondo Hiromi , Ito Hiroki , Tomioka Masayuki , Kawashima Keisuke , Kato Daiki , Iinuma Koji , Nakane Keita 
Published: October 2020

IntroductionThe patients with prostate cancer and low‐volume osseous metastases who underwent local definitive therapies had lower risks of cancer‐specific mortality. The usefulness of local definitive therapy for metastatic prostate cancer remains unclear.Case presentationA 76‐year‐old man visited a private hospital with a chief complaint of left lower limb pain. His serum prostate‐specific antigen level was 365.156 ng/mL. Histological evaluation led to the initial diagnosis of adenocarcinoma of Gleason score 4 + 4 and clinical stage T3a N1 M1b. Although androgen deprivation therapy was performed, he developed metastatic castration‐resistant prostate cancer 6 months after the initial treatment. Therefore, he received enzalutamide and attained a serum prostate‐specific antigen level of 0.002 ng/mL 7 months after the second treatment. We performed robot‐assisted radical prostatectomy 1 year after diagnosis. Histopathological examination revealed that prostate cancer cells disappeared into the prostate.ConclusionRobot‐assisted radical prostatectomy in selected patients with metastatic castration‐resistant prostate cancer may improve oncological outcomes.
Introduction to Systems Security Engineering Vocabulary
Authors:   INCOSE Systems Security Engineering Working Group
Published: October 2020

ABSTRACTSystems security protects a system from misuse and malicious behavior and makes sure the system can deliver value even under adverse conditions in cyberspace. This article identifies essential systems security vocabulary including systems security engineering, cyberspace, cyber‐attack, cybersecurity, and cyber resiliency. This terminology overview supports effective collaboration with other INCOSE working groups.
Introduction to Product Line Engineering Vocabulary
Authors:   INCOSE Product Line Engineering Working Group
Published: October 2020

ABSTRACTFeature‐based product line engineering (PLE) designs a portfolio of products using variation management to maximize value of commonality and manage differences. This article identifies essential product line vocabulary including product line engineering, shared assets, feature catalogue, bill‐of‐features, PLE factory configurator, and product asset instances. This terminology overview supports effective collaboration with other INCOSE working groups and summarizes the INCOSE PLE Primer.