bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic effects of depression and NR3C1 methylation on prognosis of acute coronary syndrome
Authors: Kang Hee-Ju , Stewart Robert , Kim Ju-Wan , Kim Sung-Wan , Shin Il-Seon , Kim Min-Chul , Hong Young Joon , Ahn Youngkeun , Shin Myung-Geun , Jeong Myung Ho , Yoon Jin-Sang , Kim Jae-Min 
Published: March 2020

AbstractHigh levels of methylation in the GR gene (nuclear receptor subfamily 3, group C, member 1; NR3C1) have been associated with depression and cardiovascular risk. This study aimed to investigate whether NR3C1 methylation status was associated with the long-term prognosis of acute coronary syndrome (ACS) considering depression and cardiovascular status at the early phase of ACS. A total of 969 patients with recent ACS were recruited at a tertiary university hospital in Korea. Baseline evaluations were made from 2007 to 2012, including DSM-IV depressive disorder, NR3C1 methylation, and various demographic and clinical characteristics such as cardiovascular risk markers. Over a 5~12 year follow-up after the index ACS, time to major adverse cardiac event (MACE) was investigated using Cox regression models. Higher NR3C1 methylation status was associated with depression and several cardiovascular risk markers at baseline. NR3C1 hypermethylation predicted worse long-term prognosis of ACS only in the presence of depressive disorder with significant synergistic interaction terms and independent of potential confounding factors. Synergistic effects of depressive disorder and NR3C1 hypermethylation on long-term cardiac outcomes in ACS were found. NR3C1 methylation status represents a candidate prognostic biomarker for ACS in combination with a diagnosis of depressive disorder. Further research is needed to ascertain the generalisability of these findings.
Hydrothermal synthesis and methylene blue adsorption performance of novel 3D hierarchical Li2Si2O5 hydrate particles
Authors: Zhang Hui , Wang Jinxiao , Yang Jianfeng 
Published: March 2020

AbstractLi2Si2O5 are generally obtained in form of granules with unavoidable impurities including Li2SiO3 and SiO2. Here, we demonstrated a facile hydrothermal route to synthesize novel 3D hierarchical Li2Si2O5 hydrate hollow flower-like microstructures assembled by rod subunits with high purity. The crystal growth was accomplished by complete transformation from poorly crystallized metastable phases formed in the initial stage including Li2SiO3, SiO2 and various Li2Si2O5 hydrate species to Li2Si2O5 hydrate rods. The transformation over many times gave a sustainable high chemical potential to direct the anisotropic growth of Li2Si2O5 hydrate rods with large aspect ratios. Besides, the variation of Li/Si molar ratios confirmed that Li2Si2O5 hydrate rods were obtained only at Li/Si = 1. The perfection and aspect ratio of the rods could be controlled very well by adjusting the hydrothermal temperatures and precursor concentrations. Some new points about obtaining pure phase and anisotropic morphology were discussed, including careful selection of precursors and synthetic method. The obtained novel 3D Li2Si2O5 hydrate structures exhibited a characteristic of mesoporous material and had an excellent adsorption capability of methylene blue with high adsorption amount of 49.42 mg·g−1 and color removal of 98.85%, indicating the potential use in wastewater treatment.
Nanosecond laser-induced surface damage and its mechanism of CaF2 optical window at 248 nm KrF excimer laser
Authors: Li Xin , Dou Xian-an , Zhu Hong , Hu Yue , Wang Xi 
Published: March 2020

AbstractCalcium fluoride (CaF2) crystals is a kind of important optical material for ultraviolet (UV) and deep-ultraviolet (DUV) lithography and high-power laser-related applications. However, its laser-induced damage threshold (LIDT) directly affects the laser power, so that the above-mentioned applications could be limited. Therefore, the research on the damage characteristics and laser damage resistance of CaF2 crystals is urgent. A 3D Finite-Difference Time-Domain (FDTD) method with Maxwell spinor equation is used, and the results show that the electric field intensity of rear surface is larger than that of front surface, which causes a lower threshold and is consistent with the experimental observations. And a thermo-mechanical coupled finite element model (FEM) of CaF2 with Ce2O3 impurities, which are introduced by polishing process, has semiquantitatively described the damage mechanism of CaF2 by 248 nm-excimer laser.
Milk microbial composition of Brazilian dairy cows entering the dry period and genomic comparison between Staphylococcus aureus strains susceptible to the bacteriophage vB_SauM-UFV_DC4
Authors: da Silva Duarte Vinícius , Treu Laura , Sartori Cristina , Dias Roberto Sousa , da Silva Paes Isabela , Vieira Marcella Silva , Santana Gabriele Rocha , Marcondes Marcos Inácio , Giacomini Alessio , Corich Viviana , Campanaro Stefano , da Silva Cynthia Canedo , de Paula Sérgio Oliveira 
Published: March 2020

AbstractBrazil has the second-largest dairy cattle herd in the world, and bovine mastitis still can cause significant losses for dairy farmers. Despite this fact, little information is available about milk microbial composition of Brazilian dairy cows, as well as the potential use of bacteriophages in the control of S. aureus. Here, we investigated milk bacterial composition of 28 Holstein Fresian cows (109 teats), selected in the dry-off period, using 16S rRNA analysis. Furthermore, a representative S. aureus strain (UFV2030RH1) was obtained at drying-off for isolation of a bacteriophage (vB_SauM-UFV_DC4, UFV_DC4) and bacterial genomic comparison purposes. Our outcomes revealed that Staphylococcus was the third most prevalent genus and positively correlated with subclinical mastitis events. As a major finding, genomic analyses showed the presence of adhesive matrix molecules that recognize microbial surface components (MSCRAMM) in UFV2030RH1 and might indicate great biofilm formation capability. A minimum inhibitory concentration (MIC) assay showed that resistance to ampicillin was the highest among the antibiotic tested in S. aureus 3059 and UFV2030RH1, displaying values four and sixteen times greater than MIC resistance breakpoint, respectively. Together, our results suggest that Staphylococcus is highly prevalent in dairy cows at drying-off and the use of the phage UFV_DC4 as a biocontrol agent must be investigated in future studies.
Association of PPM1G methylation with risk-taking in alcohol use disorder
Authors: Park Chun Il , Kim Hae Won , Hwang Syung Shick , Kang Jee In , Kim Se Joo 
Published: March 2020

AbstractAlcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of PPM1G methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at PPM1G was quantified using pyrosequencing. The effects of PPM1G methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of PPM1G was significantly associated with risk-taking propensity among men with AUD. No significant association of PPM1G methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of PPM1G may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of PPM1G in the pathophysiology of AUD and multidimensional impulsivity.
Comparison and quantitative analysis of microstructure parameters between original loess and remoulded loess under different wetting-drying cycles
Authors: Ni Wan-kui , Yuan Kang-ze , Lü Xiang-fei , Yuan Zhi-hui 
Published: March 2020

AbstractThe microstructural evolution of loess had a significant impact on the collapsibility of loess during wetting-drying cycles. Based on the analysis of scanning electron microscope (SEM) images by using Image-Pro Plus, the present study quantitatively compared the microstructural parameters of original loess and remoulded loess with different moisture content before and after wetting-drying cycles in size, shape, and arrangement. In size, the average diameter of both original loess particles and remoulded loess particles increased with the increasing of initial moisture content. However, the average diameter of original loess particles was slightly larger than that of remoulded loess particles before wetting-drying cycles. In contrast, the average diameter of both original loess particles and remoulded loess particles were very close to each other after three wetting-drying cycles. In shape, before wetting-drying cycles, the average shape factor of original loess particles was higher than that of remoulded loess particles. After three wetting-drying cycles, the difference in the average shape factor of both two loess samples with 5% initial moisture content is similar to that before wetting-drying cycles. Nevertheless, the average shape factor of both original loess particles and remouled loess particles with 15% initial moisture content were very close to that with 25% initial moisture content. In the arrangement, directional frequency indicated remoulded loess appeared to be more vertically aligned than original before and after three wetting-drying cycles. Furthermore, the directed anisotropy rate of remoulded loess was higher than that of the original loess before and after three wetting-drying cycles. In summary, the size, shape, and arrangement of both original loess particles and remoulded loess particles varied in different degrees before and after three wetting-drying cycles. Combined with the water retention curve of the loess, we analyzed the microstructural evolution mechanism of two loess particles during wetting-drying cycles. It is an excellent significance to study the engineering properties of original loess and remoulded loess.
Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors
Authors: Ren Huanhuan , Li Jian , Zhang Ning , Hu Liaoyuan A. , Ma Yingli , Tagari Philip , Xu Jianqing , Zhang Mei-Yun 
Published: March 2020

AbstractHybridoma and phage display are two powerful technologies for isolating target-specific monoclonal antibodies based on the binding. However, for complex membrane proteins, such as G protein-coupled receptors (GPCRs), binding-based screening rarely results in functional antibodies. Here we describe a function-based high-throughput screening method for quickly identifying antibody antagonists and agonists against GPCRs by combining glycosylphosphatidylinositol-anchored antibody cell display with β-arrestin recruitment-based cell sorting and screening. This method links antibody genotype with phenotype and is applicable to all GPCR targets. We validated this method by identifying a panel of antibody antagonists and an antibody agonist to the human apelin receptor from an immune antibody repertoire. In contrast, we obtained only neutral binders and antibody antagonists from the same repertoire by phage display, suggesting that the new approach described here is more efficient than traditional methods in isolating functional antibodies. This new method may create a new paradigm in antibody drug discovery.
Applying the Jellium model to octacarbonyl metal complexes
Authors: Wang Kun , Xu Chang , Li Dan , Cheng Longjiu 
Published: March 2020

AbstractThe recently reported octacarbonyl metal complexes M(CO)8 (M = Ca, Sr, Ba) feature interesting bonding structures. In these compounds, the bond order is 7, while accommodating 8 lone pairs of ligands in forming octa-coordinated complexes or ions. Here, by comparing [Ba(CO)8]2− and metal clusters of [BaBe8]2− analogically, we demonstrate that the Jellium model can not only be applied on metal clusters, but is also a useful tool to understand the electronic structures of [M(CO)8]q (M, q = Ca, 2−; Sc, 1−; Ti, 0; V, 1+; Cr, 2+; Ba, 2−). By applying the Jellium model, we find that a 20-e model with the configuration |1S2|1P6|1D10|1F2| is an appropriate description of the valence bonding structures of M(CO)8 species, where each coordinative bond contains 7/8ths of the bonding orbitals and 1/8th non-bonding orbitals.
Organically templated zinc selenite compounds: synthesis, structural chemistry and DFT calculations
Authors: Lunardi Andressa , Nunes Cechin Camila , Lang Ernesto Schulz , Cargnelutti Roberta , Ramirez Pineda Nahum , Piquini Paulo Cesar , Burrow Robert Alan , Santos dos Santos Sailer , Bortolotto Tanize , Tirloni Bárbara 
Published: March 2020

The first examples of organically templated zinc selenite compounds containing closed-frameworks have been synthesized via solvothermal processes and characterized by spectroscopy, crystallographic methods and DFT calculations.
Einflussfaktoren auf die Haftfestigkeiten neuer und unterschiedlich recycelter Brackets
Authors: Wendl Brigitte , Muchitsch Peter , Jakse Norbert 
Published: March 2020

ZusammenfassungZiel der Arbeit war die Messung der Haftfestigkeiten neuer und unterschiedlich recycelter Brackets unter Verwendung verschiedener Kleber auf intakter Schmelzoberfläche und bei Wiederholungsklebung sowie die elektronenmikroskopische Beurteilung der Bracketbasen.
Klasse III interzeptive Behandlung: Ist die Gesichtsmaske das Mittel der Wahl? Ein Fallbericht
Authors: Kokkinos Petros P. , Feldner Josef A. 
Published: March 2020

ZusammenfassungDer vorliegende Fallbericht zeigt ein alternatives Behandlungskonzept zur Therapie der Klasse III im Sinne einer interzeptiven Behandlung. Die 8 Jahre alte Patientin wies eine dentale und skelettale Klasse III auf. Die Behandlung erfolgte mittels laborgefertigten Overlays, die auf die Milchmolaren 75 und 85 gebondet wurden. Sie erfolgte basierend auf dem „Cybernetic Theory of Craniofacial Growth“ von Prof. Alexander Petrovic. Dadurch kommt es zu einer Vertikalisierung und Autorotation des Unterkiefers, durch welche sich ein dynamisches Verhältnis zwischen Ober-, Unterkiefer und den kranialen Schädelknochen einstellt. Zusätzlich zur Therapie der Klasse III wurde entschieden, schon eine leichte Lückenöffnung Regio 12 und 22 durchzuführen, um den Durchbruch der lateralen Schneidezähne zu gewährleisten.
Pilotstudie: Vergleich der Artefakte von Brackets mittels Dual-Energy-CT
Authors: Kasslatter Manuel , Glodny Bernhard , Grams Astrid , Crismani Adriano , Schieffer Lisa 
Published: March 2020

ZusammenfassungUntersuchungen zur Anwendung der monochromen (MC) Bildgebung nach Implantation metallischer Materialien an den Extremitäten oder der Wirbelsäule haben gezeigt, dass dadurch verursachte Artefakte deutlich reduziert werden können. Aufgrund der hohen Ordnungszahlen und der hohen Dichte der in der Kieferorthopädie, Kieferchirurgie und Zahnerhaltung verwendeten Materialien stellen Aufhärtungsartefakte ein großes Problem bei der Computertomografie-Bildgebung (CT) der Zähne und des Kiefers dar. Die verursachten Einschränkungen der Bildqualität bei der Darstellung der Kiefer und denkbare Verbesserungsmöglichkeiten sind bisher unzureichend untersucht. Das Ziel dieser Arbeit war, die oben genannten Artefakte zu untersuchen und diese durch Erzeugung von Monochromen im Zahn- und Kieferbereich zu reduzieren. Dual-Energy-Computertomografien (DECTs) wurden an 10 Leichenköpfen mit und ohne kieferorthopädische Apparatur durchgeführt. Anschließend wurden MC von 80 bis 160 kV generiert. Die Artefakte wurden mit etablierten Methoden qualitativ und quantitativ beurteilt. An anatomischen Strukturen wie dem Mundboden und dem weichen Gaumen, die sich nicht in der gleichen axialen Ebene mit stark artefaktproduzierenden Objekten mit hoher Ordnungszahl befinden, konnte mit zunehmender kV-Zahl der MC eine Zunahme der Hounsfieldeinheiten (HE) beobachtet werden. An Strukturen in der gleichen Ebene mit artefaktproduzierenden Objekten konnte mit zunehmender kV-Zahl der MC eine Abnahme der HE beobachtet werden. Diese Studie zeigt, dass es auch im Kieferbereich möglich ist mittels MC Artefaktreduktion zu betreiben. In allen Untersuchungen konnten keine signifikant erhöhten Artefakte im Setting mit KFO-Apparatur im Vergleich zum Setting ohne KFO-Apparatur festgestellt werden.
Klasse-III-Behandlung mittels Multiloop Edgewise Archwire – ein Fallbericht
Authors: Kokkinos Petros P. , Feldner Josef A. 
Published: March 2020

ZusammenfassungDer vorliegende Fallbericht zeigt die Therapie und das Behandlungskonzept eines Adoleszenten mit einer Klasse-III-Malokklusion. Der zum Start der Behandlung 17 Jahre alte Patient wies eine skelettale und dentale Klasse III auf. Es bestand ein Kreuzbiss bei den Zähnen 15 und 12–23, ein Kantbiss an den Zähnen 16, 14 und 13; der Zahn 13 war zusätzlich bukkal ausgeblockt. Die Therapie erfolgte mittels der von H. Kim in den frühen 1970er Jahren erstmals beschriebenen Multiloop Edgewise Archwire Technik.
Pre-Ablation rhTSH-Stimulated F-18 FDG PET/CT Changes Patient
Management in Increased-Risk Thyroid Cancer
Authors: Rendl Gundula , Rettenbacher Lukas , Schweighofer-Zwink Gregor , Hehenwarter Lukas , Pirich Christian 
Published: March 2020

AbstractThe aim of the study was to evaluate the clinical impact of pre-ablation
rhTSH-stimulated fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT in
addition to post-therapeutic whole body radioiodine scanning in patients
with intermediate to high risk differentiated thyroid carcinoma (DTC). This
was a retrospective single center study including 73 patients with thyroid
cancer (44 females, mean age 43.2±16.2 years, 62% papillary,
31% follicular, 7% poorly differentiated). All patients
underwent ablative radioiodine treatment (mean activity: 3661±673
MBq I-131) using rhTSH after thyroidectomy and lymph node (LN) dissection
(01/2013–10/2016) and TSH-stimulated F-18 FDG
PET/CT (4 MBq/kg body weight, low dose CT). Post-treatment
I-131 whole body scan (I-131 WBS) was obtained 9 days afterwards in planar
technique and in case of equivocal or abnormal findings using
SPECT/CT. Thirty-one patients (42%) showed F-18 FDG avid
lesions, 14 patients showed more FDG than iodine positive lesions and 5
patients more iodine positive lesions in I-131 WBS, respectively.
Fifty-three patients showed identical F-18 FDG PET/CT and I-131 WBS.
The initial treatment plan was changed from follow-up to therapy (surgery,
systemic therapy using tyrosine-kinase inhibition) in 11 patients
(15%) on the basis of F-18 FDG PET/CT imaging. Six of these
11 patients had papillary thyroid cancer. Three patients with histologically
proven LN metastases had stimulated
thyroglobulin-levels<2.0 ng/ml. Our study
demonstrated a clinical benefit of pre-ablation rhTSH-stimulated F-18 FDG
PET/CT imaging in about 20% of patients with intermediate to
high risk DTC, leading to change in patient management in 15%.
Effect of Intravenous 25OHD Supplementation on Bone Turnover and
Inflammation in Prolonged Critically Ill Patients
Authors: Ingels Catherine , Vanhorebeek Ilse , Van Cromphaut Sophie , Wouters Pieter J. , Derese Inge , Dehouwer Alexander , Møller Holger Jon , Hansen Troels K. , Billen Jaak , Mathieu Chantal , Bouillon Roger , Van den Berghe Greet 
Published: March 2020

AbstractCritically ill patients have low circulating 25-hydroxyvitamin D (25OHD),
vitamin D binding protein (DBP), and 1,25-dihydroxyvitamin D
[1,25(OH)2D]. Low 25OHD is associated with poor outcomes,
possibly explained by its effect on bone and immunity. In this prospective,
randomized double-blind, placebo-controlled study, we investigated the
feasibility of normalizing 25OHD in prolonged (>10 days) critically
ill patients and the effects thereof on 1,25(OH)2D, bone
metabolism, and innate immunity. Twenty-four patients were included and
compared with 24 matched healthy subjects. Patients were randomized to
either intravenous bolus of 200 μg 25OHD followed by daily
infusion of 15 μg 25OHD for 10 days, or to placebo.
Parameters of vitamin D, bone and mineral metabolism, and innate immune
function were measured. As safety endpoints, ICU length of stay and
mortality were registered. Infusion of 25OHD resulted in a sustained
increase of serum 25OHD (from median baseline
9.2 –16.1 ng/ml at day 10), which,
however, remained below normal levels. There was no increase in serum
1,25(OH)2D but a slight increase in serum
24,25(OH)2D. Mineral homeostasis, innate immunity and
clinical safety endpoints were unaffected. Thus, intravenous 25OHD
administration during critical illness increased serum 25OHD concentrations,
though less than expected from data in healthy subjects, which suggests
illness-induced alterations in 25OHD metabolism and/or increased
25OHD distribution volume. The increased serum 25OHD concentrations were not
followed by a rise in 1,25(OH)2D nor were bone metabolism or
innate immunity affected, which suggests that low 25OHD and 1,25OHD levels
are part of the adaptive response to critical illness.
Imaging of otosclerosis
Authors: Kösling Sabrina , Plontke Stefan K , Bartel Sylva 
Published: March 2020

Background Otosclerosis is an important cause of hearing loss and a widespread pathology in ENT medicine. Although a high diagnostic value of CT with impact on therapy is emphasized in the literature, the disease is seldom seen in the radiological routine diagnostics due to ENT findings often being diagnostic. Radiologists detect it rather more often in cases of unclear hearing loss or cochlear implant candidates. The findings may be very subtle. They require a target search and an optimal imaging technique.
Methods This review article is based on a selective search of the literature in PubMed without any time frame restrictions as well as on the long clinical experience of the authors.
Results The paper focuses on imaging aspects of otosclerosis: current role, advice for imaging technique, characteristic imaging signs, radiological differential diagnoses and findings after stapedoplasty. Pathology, clinical signs and therapeutic options are summarized briefly.
Conclusions With an optimal technique and sufficient radiological experience otosclerosis can be correctly diagnosed by imaging in a high percentage of cases. Radiology plays the key role in the diagnosis of retrofenestral otosclerosis. It can provide valuable information for the management of complications after stapedotomy.
Key points:
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Genomics and Interventional Oncology in Primary Liver Cancer
Authors: Slovak Ryan , Dendy Case Meaghan , Kim Hyun S. 
Published: March 2020

AbstractPersonalized medicine is revolutionizing oncologic care. Molecular and imaging “fingerprinting” of cancer through genomics, radiomics, and radiogenomics has allowed for the meticulous characterization of many forms of malignancy, including primary liver cancers. With this data, treatments are being developed that precisely target and exploit key variations in individual tumors. As these methods continue to evolve, interventional oncologists are well positioned to capitalize on the advances being made. This article will provide a concise overview of the genomic, radiomic, and radiogenomic research on hepatocellular carcinoma and intrahepatic cholangiocarcinoma, in addition to discussions on how precision medicine would relate to interventional oncology.