bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiRNA-10b marks aggressive squamous cell carcinomas, and confers a cancer stem cell-like phenotype
Authors: Wimmer Monika , Zauner Roland , Ablinger Michael , Piñón-Hofbauer Josefina , Guttmann-Gruber Christina , Reisenberger Manuela , Lettner Thomas , Niklas Norbert , Proell Johannes , Sajinovic Mila , De Souza Paul , Hainzl Stefan , Kocher Thomas , Murauer Eva M. , Bauer Johann W. , Strunk Dirk , Reichelt Julia , Mellick Albert S. , Wally Verena 
Published: February 2020

AbstractBackgroundCutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa, which is in marked contrast to the rarely metastasizing nature of these carcinomas in the general population. This remarkable difference is attributed to the frequent development of chronic wounds caused by an impaired skin integrity. However, the specific molecular and cellular changes to malignancy, and whether there are common players in different types of aggressive cSCCs, remain relatively undefined.MethodsMiRNA expression profiling was performed across various cell types isolated from skin and cSCCs. Microarray results were confirmed by qPCR and by an optimizedin situhybridization protocol. Functional impact of overexpression of a dysregulated miRNA was assessed in migration and 3D spheroid assays. Sample-matched transcriptome data was generated to support the identification of disease relevant miRNA targets.ResultsSeveral miRNAs were identified as dysregulated in cSCCs as compared to controls. These included the metastasis-linked miR-10b, which was significantly upregulated in primary cell cultures and in archival biopsies. At the functional level, overexpression of miR-10b conferred the stem cell-characteristic of 3D-spheroid formation capacity to keratinocytes, and impaired their mobility. Analysis of miR-10b downstream effects identified a novel putative target of miR-10b, the actin- and tubulin cytoskeleton-associated protein DIAPH2.ConclusionThe discovery that miR-10b confers an aspect of cancer stemness – that of enhanced tumor cell adhesion, known to facilitate metastatic colonization - provides an important avenue for future development of novel therapies targeting this metastasis-linked miRNA.
Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy
Authors: Heberle Frederick A. , Doktorova Milka , Scott Haden L. , Skinkle Allison , Waxham M. Neal , Levental Ilya 
Published: February 2020

ABSTRACTThe nanoscale organization of biological membranes into structurally and compositionally distinct lateral domains is believed to be central to membrane function. The nature of this organization has remained elusive due to a lack of methods to directly probe nanoscopic membrane features. We show here that cryogenic electron microscopy (cryoEM) can be used to directly image coexisting nanoscopic domains in synthetic and bio-derived membranes without extrinsic probes. Analyzing a series of single-component liposomes composed of synthetic lipids of varying lengths, we demonstrate that cryoEM can distinguish bilayer thickness differences as small as 0.5 Å, comparable to the resolution of small-angle scattering methods. Simulated images from computational models reveal that features in cryoEM images result from a complex interplay between the atomic distribution normal to the plane of the bilayer and imaging parameters. Simulations of phase separated bilayers were used to predict two sources of contrast between coexisting ordered and disordered phases within a single liposome, namely differences in membrane thickness and molecular density. We observe both sources of contrast in biomimetic membranes composed of saturated lipids, unsaturated lipids, and cholesterol. When extended to isolated mammalian plasma membranes, these methods reveal similar nanoscale lateral heterogeneities. The methods reported here for direct, probe-free imaging of nanodomains in unperturbed membranes open new avenues for investigation of nanoscopic membrane organization.SIGNIFICANCEWe have used cryoEM to achieve direct, probe-free imaging of lateral domains in biomimetic lipid membranes under native conditions and to characterize differences in their structures. First, measurements of membrane thickness in laterally uniform single-component membranes show that cryoEM is capable of sub-angstrom resolution of interleaflet membrane thickness. All-atom simulations are used to predict the cryo-EM appearance of submicron domains in vesicles with coexisting liquid domains and these are quantitatively validated by direct imaging of phase separated membranes. We then extend this approach to observe nanoscopic domains in isolated cellular membranes, comprising the first direct imaging of nanodomains in biomembranes.
A multi-theoretical framework to better understand the college major choice in arts and design
Authors: Sudhana Pranakusuma , Ameen Ali , Isaac Osama 
Published: February 2020

PurposeThis paper aims to identify career development theories that explain the intention to choose college majors in arts and design, to integrate the identified theories and to examine the relationships between determinants of the integrated model. In addition, this study attempts to identify the characteristics of the prospective arts and design students.Design/methodology/approachThe literature review resulted in a multitheoretical framework named as PERISCOPE (Personality of Holland's RIASEC in Social Cognitive and Planned Behavior Theories) to reflect the theories it consisted of. This study collected data from Year 12 students in Surabaya (n = 163) and used PLS-SEM technique to assess the measurement model and the structural model of such framework.FindingsThe results revealed that the integrated model explains 57.8 percent of the variance of the intention to pursue arts and design majors. This paper hence improves the predictive ability of an earlier model by adding a further theory. In addition, this study identified characteristics of the prospective students and concluded that students with artistic personality will have better self-efficacy, which sequentially have perception that pursuing arts and design majors will not be challenging, thus increases their intention to pursue such majors.Originality/valueThis study demonstrated that PERISCOPE framework is better in terms of predictive power in understanding the college major choice in arts and design. As a result, this study adds to the current body of knowledge in the field of college major choice, which was found to be lacking.
Vulnerability as a driver of the police response to fraud
Authors: Skidmore Michael , Goldstraw-White Janice , Gill Martin 
Published: February 2020

Purpose
Frameworks for understanding victim harm and vulnerability have become central to priority-setting and resource allocation for decision-makers in the police and government in the UK. This paper aims to look at the meaning of vulnerability in the context of fraud.

Design/methodology/approach
The research took a mixed methods approach, including analysis of national crime data (n = 61,902), qualitative data collected from interviews with practitioners (n = 107) and a survey of strategic lead officers in the police (n = 32).

Findings
There was a lack of clarity across practitioners and organisations in their understanding of vulnerability and the way it informed the police response to fraud, and a lack of resources and capability for identifying it.

Research limitations/implications
The authors invite reconsideration of the approach to fraud victims which have for too long been forgotten by response and support agencies.

Practical implications
We need to standardise and agree the definition of “vulnerability”; rethink eligibility levels; and refocus police on fraud victims taking vulnerability as a meaningful criterion in deciding who to support.

Originality/value
There is very little research on vulnerability and fraud victims; this paper, based on original research, fills this gap.
A study of cybercrime victimisation and prevention: exploring the use of online crime prevention behaviours and strategies
Authors: Drew Jacqueline M. 
Published: February 2020

Purpose
The evolution of digital technology has changed the way in which we, as a global society, socialise and conduct business. This growth has led to an increasing reliance on technology, much more interconnectedness and in turn, an expansion of criminal opportunities, known now as “cybercrime”. This study aims to explore the experience of victimisation, perceptions of cybercrime and use of online crime prevention strategies.

Design/methodology/approach
The study involved a survey of a representative sample of the adult Australian population. The study sample was made up of 595 Australian adult participants. The study seeks to better understand how previous victimisation, perception of cybercrime prevalence and perception of harm caused by cybercrime are related to the use of online crime prevention strategies. It seeks to contribute to a body of work that has found that crime prevention education focused on increasing knowledge is limited in its effectiveness in reducing victimisation.

Findings
This study identifies key levers, in particular perceived prevalence and harm of cybercrime, as critical in the use of online crime prevention strategies by potential victims.

Research limitations/implications
As such, this study provides an important evidence base on which to develop more effective online crime prevention education and awareness campaigns to reduce cybervictimisation.

Practical implications
The practical implications include the relationship between cybervictimisation and self-protective online strategies of potential victims and the development of more effective online crime prevention programmes.

Originality/value
The research takes a different perspective from much of the previous research, seeking to better understand how attitudinal factors (perceived prevalence of cybercrime and perceived harm of cybercrime) might motivate or influence the use of online crime prevention strategies by potential victims.
The role of investment property appraisal in European real estate companies
Authors: Mäki Juha 
Published: February 2020

Purpose
This paper aims to examine the connection between appraisals of investment properties and earnings properties in companies from two perspectives: what kinds of companies employ the most reputable appraisers and how appraisers produce estimations.

Design/methodology/approach
The research uses annual reports of European Union (EU) publicly traded real estate companies and examines the period 2007-2016.

Findings
The contribution of this study lies in establishing that some indicators and features of real estate companies affect the choice of appraiser and also in illustrating differences in the results of property valuations. In short, smaller companies with weaker performance are less willing to use external valuation, and external appraisers produce more conservative estimations for investment properties.

Practical implications
The research produces beneficial information for investors and other stakeholders interested in the real estate industry.

Originality/value
This is the first novel study to examine the link between appraisals of investment properties and earnings properties in companies in detail.
Understanding consumer motivation to share IoT products data
Authors: Bhatnagar Sushant , Kumra Rajeev 
Published: February 2020

Purpose
Almost every study undertaken by academicians or practitioners on the Internet of Things (IoT) has mainly highlighted the privacy concerns and information security issues with the IoT products. On the contrary, this paper aims to explore the motivators that could encourage customers of an IoT product to share their IoT product’s data with a third-party aggregator system to facilitate computer-generated product reviews which are defined as electronic Word of Thing (eWOT) in this paper.

Design/methodology/approach
An experiment was conducted with customized e-commerce prototypes of eWOT. Structural equation modeling analysis was conducted to test the measurement model by using confirmatory factor analysis and thereafter a structural model to test the relationships amongst the latent variables.

Findings
This paper found that five consumer motivators (personal innovativeness, enjoyment of helping, anticipated extrinsic rewards, moral obligations and venting negative feelings) contribute to eWOT intention.

Practical implications
This research advances the understanding of human interaction with computer-generated product reviews and opens up avenues for future studies in online consumer behavior in the IoT context.

Originality/value
This paper presents motivators for eWOT intention to share IoT product data. This is done through a novel concept of an experimental IoT-based prototype, namely, eWOT. These eWOT reviews can be generated from the IoT products data by applying analytics and using natural language generation. To the best of the authors’ knowledge, no other study has been conducted on this subject.
Uncovering the potential of urban culture for creative placemaking
Authors: Zuma Banoyi , Rooijackers Margo 
Published: February 2020

Purpose
The authors provide a personal insight into how they see the potential of urban culture as a vehicle for creative placemaking. The purpose of this study is to highlight the opportunities for the tourism industry to embrace this global youth culture now that one of its pillars, breakdance, is on the brink of becoming an Olympic discipline in 2024, thus nudging this youth culture from underground to mainstream.

Design/methodology/approach
The authors interviewed two Dutch pioneers in the field of urban culture: Tyrone van der Meer, founder of The Notorious IBE (IBE), an international breaking event, and Angelo Martinus, founder of the urban scene in Eindhoven and initiator of EMOVES, an urban culture and sports event.

Findings
The authors illustrate the added value of urban culture to creative placemaking by addressing the initiatives of previously mentioned Dutch pioneers. Their urban culture events on Dutch soil, yearly attract thousands of participants and visitors from the urban scene, covering over 40 nationalities, to the South of The Netherlands.

Originality/value
This study provides a glimpse into a global youth culture that is primarily invisible to the tourism industry and a foresight in how the tourism industry and other stakeholders (e.g. policy makers, city marketeers, tourism managers and event organisers) can pick up on this evolving trend. The study is meant as a wake-up call.
Multimodal transportation via TSR for effective Northern logistics
Authors: Kim Gi-Su , Lee Sung-Woo , Seo Young-Joon , Kim A-Rom 
Published: February 2020

PurposeThis paper aims to identify the factors that experts consider important for the effective operation of multimodal transport using the Trans-Siberian Railway (TSR) in the Russian Far East and to also establish operational strategies that enable Korean logistics companies to use TSR efficiently for multimodal transportation.Design/methodology/approachA total of 65 questionnaires were distributed to predominantly Korean logistics companies/shippers with experience in TSR and 19 replies were received. The majority of the respondents are senior executives with at least 10 years of work experience. To identify the factors and present strategies, this study applied the strengths, weaknesses, threats and opportunities -fuzzy analytic hierarchy process (FAHP) method, which is based on complex multiple-criteria decision-making (MCDM) that facilitates decision-makers in considering an operational strategy by calculating the importance of input factors.FindingsResults from the FAHP indicate that the Strengths is the main factor affecting TSR multimodal transport decisions, followed by the Threats, Opportunities and Weakness factors. In terms of rank, reduction of transportation distance and time are determined as the most crucial factor from the perspective of Korean logistics companies, followed by the northern logistics development plan, the Russian Government's willingness to the development plan, political instability and possible linkages with the Korean ports.Originality/valueThrough a hybrid MCDM analysis of Korean logistics companies, three operational strategies were proposed: foreign direct and small investments in the Russian Far East, Korean logistics companies implementing a cold-chain logistics service in the fishery industry and a government-led “Block Train Integration System” to secure the minimum threshold volume of cargo for small and medium-sized companies.
Hello Brand, let’s take a selfie
Authors: Uzunboylu Naziyet , Melanthiou Yioula , Papasolomou Ioanna 
Published: February 2020

Purpose
It has been suggested that brands and products often assume a role in selfies (Ham, 2014) where the expression of brands and products provokes consumer emotions that bring about greater engagement (Tsai and Men, 2013) and contributes to the interactivity with the brands. This study aims to understand how the selfie phenomenon could mobilize the interactivity between brands and target audiences, in a way that could be used as a marketing tool by companies.

Design/methodology/approach
A netnographic research methodology was used for the current study because it is a method specifically designed to study online communities (Kozinets, 2010). The experiences of brand selfie postings on Instagram were studied by analyzing users’ selfies to predict brand usage. A purposive sample of Instagram users was chosen, and from these, a total of 74 brand selfies were analyzed.

Findings
This study provided an understanding of consumer behavior and marketing practices in the social marketplace through a detailed exploration of the data using visual and textual analysis. The main finding of this study is that consumers both consume and produce brand meanings in digital platforms; hence, companies should view them not only as passive receivers of messages, but also potential generators and co-creators of brand messages.

Research limitations/implications
An important limitation of this study is that it only examines a small number of cases, and conclusions can only be limited to the specific sample chosen. A future research endeavor could of course be carried out to include a larger sample audience for investigating the effect of brand selfies and the potential purchase decisions of peers following exposure. Theoretically, this study provided further insight into the selfie phenomenon and specifically as a marketing tool and not just a new social trend.

Originality/value
The growing trend in the selfie phenomenon along with social networking sites (hereinafter SNSs) have attracted the attention of both users and marketing experts in terms of consumer–brand relationship (Zhu and Chen, 2015). In line with this current trend, many studies have attempted to understand the influential impact of the selfie phenomenon through SNSs. Studies on the motivation of selfie postings (Pounders et al., 2016) and selfie-posting behavior on SNSs (Kim et al., 2016) have been carried out; however, how brand selfies posted on SNSs appeal to non-users and how they interact with them remain unclear. Consequently, the intention of the current study is to provide some insight in this area.
Developing corporate communications: insights from the Italian scenario
Authors: Palazzo Maria , Foroudi Pantea , Kitchen Philip J. , Siano Alfonso 
Published: February 2020

PurposeBased on the managerial perceptions from large firms, this paper aims to explore the emergence, growth and importance of corporate communications and how it is evolving and creating competitive advantage for Italian firms.Design/methodology/approachA qualitative approach is deployed, comprising in-depth interviews with senior managers from Italian corporations from a broad spectrum of industries, including: energy, telecommunications, automotive, transport, retail chain, appliances, technology and engineering, private shipping, government-owned holdings, marketing consultancy and construction.FindingsThe paper offers insight into corporate communications (corpcoms) practices in the sampled companies. The paper shows that corpcoms involves a complex range of activities leading to performance – managed and implemented under CEO direction.Practical implicationsCorpcoms is perceived as a strategic concept with effective application relative to managing corporate image and reputation. The findings offer insights for communication professionals who deal with corpcoms, branding and marketing communications.Originality/valueCorpcoms can be viewed via the lens of social actors’ perspectives, i.e. via practitioners – including brand managers and senior executives, as they possess practical knowledge of business practice in specific contextual business settings and have the managerial ability and remit to design, implement and evaluate integrated corpcoms.
A tale of two coffees? Analysing interaction and futures market efficiency
Authors: Holmes Mark J. , Otero Jesús 
Published: February 2020

PurposeThe purpose of this paper is to assess the informational efficiency of Arabica (other milds) and Robusta coffee futures markets in terms of predicting future coffee spot prices.Design/methodology/approachFutures market efficiency is associated with the existence of a long-run equilibrium relationship between spot and future prices such that coffee futures prices are unbiased predictors of future spot prices. This study applies unit root testing to daily data for futures-spot price differentials. A range of maturities for futures contracts are considered, and the study also uses a recursive approach to consider time variation in futures market efficiency.FindingsThe other milds and Robusta futures prices tend to be unbiased predictors for their own respective spot prices. The paper further finds that other milds and Robusta futures prices are unbiased predictors of the respective Robusta and other milds spot prices. Recursive estimation suggests that the futures market efficiency associated with these cross cases has increased, though with no clear link to the implementation of the 2007 International Coffee Agreement.Originality/valueThe paper draws new insights into futures market efficiency by examining the two key types of coffee and analyses the potential interactions between them. Hitherto, no attention has been paid to futures contracts of the Robusta variety. The employment of unit root testing of spot futures coffee price differentials can be viewed as more stringent than an approach based on non-cointegration testing.