bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine
Authors: Tiba Mohamad Hakam , McCracken Brendan M. , Dickson Robert P. , Nemzek Jean A. , Colmenero Carmen I. , Leander Danielle C. , Flott Thomas L. , Daniels Rodney C. , Konopka Kristine E. , VanEpps J. Scott , Stringer Kathleen A. , Ward Kevin R. 
Published: December 2020

Background
The systemic responses to infection and its progression to sepsis remains poorly understood. Progress in the field has been stifled by the shortcomings of experimental models which include poor replication of the human condition. To address these challenges, we developed and piloted a novel large animal model of severe infection that is capable of generating multi-system clinically relevant data.

Methods
Male swine (n = 5) were anesthetized, mechanically ventilated, and surgically instrumented for continuous hemodynamic monitoring and serial blood sampling. Animals were inoculated with uropathogenic E. coli by direct injection into the renal parenchyma and were maintained until a priori endpoints were met. The natural history of the infection was studied. Animals were not resuscitated. Multi-system data were collected hourly to 6 hours; all animals were euthanized at predetermined physiologic endpoints.

Results
Core body temperature progressively increased from mean (SD) 37.9(0.8)°C at baseline to 43.0(1.2)°C at experiment termination (p = 0.006). Mean arterial pressure did not begin to decline until 6h post inoculation, dropping from 86(9) mmHg at baseline to 28(5) mmHg (p = 0.005) at termination. Blood glucose progressively declined but lactate levels did not elevate until the last hours of the experiment. There were also temporal changes in whole blood concentrations of a number of metabolites including increases in the catecholamine precursors, tyrosine (p = 0.005) and phenylalanine (p = 0.005). Lung, liver, and kidney function parameters worsened as infection progressed and at study termination there was histopathological evidence of injury in these end-organs.

Conclusion
We demonstrate a versatile, multi-system, longitudinal, swine model of infection that could be used to further our understanding of the mechanisms that underlie infection-induced multi-organ dysfunction and failure, optimize resuscitation protocols and test therapeutic interventions. Such a model could improve translation of findings from the bench to the bedside, circumventing a significant obstacle in sepsis research.
Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD
Authors: Vilar-Gomez Eduardo , Pirola Carlos Jose , Sookoian Silvia , Wilson Laura A. , Belt Patricia , Liang Tiebing , Liu Wanqing , Chalasani Naga 
Published: December 2020

INTRODUCTION:
This study explored the relationship between patatin-like phospholipase domain-containing 3 gene (PNPLA3 rs738409), nutrient intake, and liver histology severity in patients with nonalcoholic fatty liver disease (NAFLD).

METHODS:

PNPLA3-rs738409 variant was genotyped in 452 non-Hispanic whites with histologically confirmed NAFLD who completed Food Frequency Questionnaire within 6 months of their liver biopsy. The fibrosis severity on liver histology was the outcome of interest.

RESULTS:
The distribution of PNPLA3 genotypes was CC: 28%, CG: 46%, and GG: 25%. High-carbohydrate (% of energy/d) intake was positively associated (adjusted [Adj] odds ratio [OR]: 1.03, P < 0.01), whereas higher n-3 polyunsaturated fatty acids (n-3 PUFAs) (g/d) (Adj. OR: 0.17, P < 0.01), isoflavones (mg/d) (Adj. OR: 0.74, P = 0.049), methionine (mg/d) (Adj. OR: 0.32, P < 0.01), and choline (mg/d) (Adj. OR: 0.32, P < 0.01) intakes were inversely associated with increased risk of significant fibrosis (stage of fibrosis ≥2). By using an additive model of inheritance, our moderation analysis showed that PNPLA3 rs738409 significantly modulates the relationship between carbohydrate (%), n-3 PUFAs, total isoflavones, methionine, and choline intakes and fibrosis severity in a dose-dependent, genotype manner. These dietary factors tended to have a larger and significant effect on fibrosis severity among rs738409 G-allele carriers. Associations between significant fibrosis and carbohydrates (Adj. OR: 1.04, P = 0.019), n-3 PUFAs (Adj. OR: 0.16, P < 0.01), isoflavones (Adj. OR: 0.65, P = 0.025), methionine (Adj. OR: 0.30, P < 0.01), and total choline (Adj. OR: 0.29, P < 0.01) intakes remained significant only among rs738409 G-allele carriers.

DISCUSSION:
This gene-diet interaction study suggests that PNPLA3 rs738409 G-allele might modulate the effect of specific dietary nutrients on risk of fibrosis in patients with NAFLD.
Learning to Synchronize: Midfrontal Theta Dynamics during Rule Switching
Authors: Verbeke Pieter , Ergo Kate , De Loof Esther , Verguts Tom 
Published: December 2020

In recent years, several hierarchical extensions of well-known learning algorithms have been proposed. For example, when stimulus-action mappings vary across time or context, the brain may learn two or more stimulus-action mappings in separate modules, and additionally (at a hierarchically higher level) learn to appropriately switch between those modules. However, how the brain mechanistically coordinates neural communication to implement such hierarchical learning remains unknown. Therefore, the current study tests a recent computational model that proposed how midfrontal theta oscillations implement such hierarchical learning via the principle of binding by synchrony (Sync model). More specifically, the Sync model uses bursts at theta frequency to flexibly bind appropriate task modules by synchrony. The 64-channel EEG signal was recorded while 27 human subjects (female: 21, male: 6) performed a probabilistic reversal learning task. In line with the Sync model, postfeedback theta power showed a linear relationship with negative prediction errors, but not with positive prediction errors. This relationship was especially pronounced for subjects with better behavioral fit (measured via Akaike information criterion) of the Sync model. Also consistent with Sync model simulations, theta phase-coupling between midfrontal electrodes and temporoparietal electrodes was stronger after negative feedback. Our data suggest that the brain uses theta power and synchronization for flexibly switching between task rule modules, as is useful, for example, when multiple stimulus-action mappings must be retained and used.SIGNIFICANCE STATEMENTEveryday life requires flexibility in switching between several rules. A key question in understanding this ability is how the brain mechanistically coordinates such switches. The current study tests a recent computational framework (Sync model) that proposed how midfrontal theta oscillations coordinate activity in hierarchically lower task-related areas. In line with predictions of this Sync model, midfrontal theta power was stronger when rule switches were most likely (strong negative prediction error), especially in subjects who obtained a better model fit. Additionally, also theta phase connectivity between midfrontal and task-related areas was increased after negative feedback. Thus, the data provided support for the hypothesis that the brain uses theta power and synchronization for flexibly switching between rules.
Valoración territorial da proposta de traslado dunha oficina de farmacia en Galicia. Un estudo de caso de Xeografía Aplicada
Authors: Miramontes Carballada Ángel 
Published: December 2020

A creación ou traslado dun servizo sempre ten unha serie de repercusións territoriais, pero se ademais se trata dunha farmacia que para exercer a súa actividade ten que cumprir unha serie de condicionantes vinculados ao número de habitantes, á distancia, etcétera, as consecuencias territoriais poden ser variadas. Por iso, a finalidade deste traballo é amosar a repercusión territorial que ocasionaría o traslado voluntario dunha oficina de farmacia dentro do Concello da Estrada (Pontevedra), entendendo como repercusión territorial a súa influencia nas características demográficas, sociais, económicas e de mobilidade da poboación deste espazo do interior de Galicia, así como sobre o servizo básico de distribución de medicamentos á poboación. Para acadar este obxectivo, realizouse un exhaustivo traballo de campo e unha análise de toda a información territorial dispoñible sobre as actuacións que se realizarán, desde o punto de vista de planificación e desenvolvemento territorial, no concello. Unha das conclusións alcanzadas foi comprobar como os límites ou as fronteiras que se crean en ocasións desde a Administración non sempre son as máis eficientes en relación coas características do territorio nin dan o mellor servizo á poboación (áreas educativas, farmacéuticas ou sanitarias).
Teacher Leadership Effects on Student Achievement and Student Satisfaction: A Meta Analysis on the Studies Published in Turkey and USA
Authors: UYSAL ŞENGÜL , SARIER YILMAZ 
Published: December 2020

Teacher leadership has grown in importance over the past decades and the growing interest results in the studies presenting direct and indirect impacts on school improvement processes and outcomes. The purpose of this study was to examine the effect of teacher leadership on student achievement and student satisfaction. The methodology involved an analysis of 22 published studies of the relationship between teacher leadership and student achievement with student satisfaction. The meta-analysis involved a comparison of the effects of teacher leadership on student achievement and student satisfaction in Turkey and USA. The results indicated that the average effect of teacher leadership on student achievement is modest and positive and it is strong and positive on student satisfaction. Comparing the countries, in Turkey the average effect of teacher leadership on student satisfaction is much stronger than it is in USA.
Experiencing Folk Music in Children
Authors: Zalar Konstanca 
Published: December 2020

Through everyday exposure to language and music, individuals within a nation become sensitive to the melodic and rhythmical structure of their folk musical culture. It represents improvisational abilities of individuals and groups as well. Despite all changes, it indisputably maintains all characteristic of music parameters as inheritance of past ages. Due to its social role, it appears throughout everyone’s life – and it also represents an important part of children’s life. In the study that was carried out with two groups of children between six and nine years of age, we were interested in determining how do children experience music making with elements of folk music and how it is possible to create the circumstances which can provide the spontaneity of folk music within the structured environment (like primary school). The research was designed as a phenomenological case study. This method allowed us to gather data which provided a deeper insight into the ways in which participants are able to play using elements of folk music and the way they feel while using such material. The results show that, contrary to the basic fact of spontaneity in folk music, 6 and 7 year old participants were not able to use music parameters to play with and had yet to learn how does the symbolic play on the basis of communication in musical language work out. The most natural way to bridge the gap between “learning” songs and experiencing individual musical expression in a manner of folk music in children seems to be a creative work with lyrics in Slovene language. We also found that children develop social competences of a great value, when they are involved in a symbolic play with folk music elements in the improvisational mode. Key words: folk music; improvisation; music language; music making
Understanding Nurses Experiences and Perception about The Implemention of Emergency Monitoring : A Qualitative Study
Authors: Kholis Anja Hesnia , Hidayah Nurul , Priyanti Ratna Puji , Asri Asri , Ellina Agusta Dian 
Published: December 2020

ABSTRACTEmergency monitoring in the hospital is very important to be carried out, as one form of responsibility for early detection of deterioration patients. The implementation of the Early Warning System in Hospital is still being evaluated by the quality of service to find out its effectiveness. The purpose of this study was to explore the experiences and perceptions of nurses about the implementation of emergency monitoring in hospital. This study was a qualitative design. Participants were 6 female team leader nurses, with average age 35.3 y.o, and average working experience 11.3 years, used purposive sampling. Data were collected by in-depth interviews and field notes. Data were analyzed using thematic analysis method by Flick. The findings of the study identified 3 themes: (1) personal themes; (2) environmental themes; (3) Patient themes. The results showed that the implementation of emergency monitoring in the inpatients units in hospital was still not optimal. The implementation of the Early Warning System is expected to be carried out on an ongoing basis so that its implementation is effective. Socialization, training, supervision, and adequate infrastructure are needed as well as consistency algorithms for early identification of the patient's condition and getting immediate assistance.ABSTRAK Pemantauan kedaruratan di rumah sakit sangat penting dilakukan, sebagai salah satu bentuk tanggung jawab untuk deteksi dini kemunduran pasien. Penerapan Sistem Peringatan Dini di Rumah Sakit masih terus dievaluasi kualitas pelayanannya untuk mengetahui efektivitasnya. Penelitian ini bertujuan untuk mengetahui pengalaman dan persepsi perawat tentang pelaksanaan pemantauan kegawatdaruratan di rumah sakit. Penelitian ini merupakan penelitian kualitatif. Peserta penelitian adalah 6 perawat ketua tim wanita, dengan usia rata-rata 35,3 tahun, dan pengalaman kerja rata-rata 11,3 tahun, menggunakan purposive sampling. Pengumpulan data dilakukan dengan wawancara mendalam dan catatan lapangan. Data dianalisis menggunakan metode analisis tematik oleh Flick. Temuan penelitian mengidentifikasi 3 tema: (1) tema pribadi; (2) tema lingkungan; (3) Tema pasien. Kesimpulan: Hasil penelitian menunjukkan bahwa pelaksanaan pemantauan kegawatdaruratan di unit rawat inap rumah sakit masih belum optimal. Penerapan Sistem Peringatan Dini diharapkan dapat dilakukan secara berkesinambungan agar pelaksanaannya efektif. Dibutuhkan sosialisasi, pelatihan, supervisi, dan infrastruktur yang memadai serta konsistensi algoritme untuk identifikasi awal kondisi pasien dan mendapatkan bantuan segera.
Rational therapy of bacterial vaginosis
Authors: T. G. Romanenko  , G. M. Zhaloba  , О. М. Sulimenko  
Published: December 2020

Purpose of the study was to evaluate the efficiency and duration of clindamycin (Banbact®) therapeutic effect in the treatment of bacterial vaginosis in women of reproductive age.Materials and methods. The study included 47 patients with bacterial vaginosis aged 20–37 years. Vaginal dysbiosis was established on the basis of symptoms indicated by women themselves, results of gynecological examination that was consisting of examination, measurement of vaginal pH based on the Amsels criteria, evaluation of vaginal microbiocenosis by polymerase chain reaction. Treatment was performed with Banbact® – vaginal suppositories clindamycin 100 mg 1 day before bedtime for 6 days.Treatment criteria were no subjective complaints, normal discharge in quantity, odor and consistency; decrease of leukocytes number in smears, secretions pH <4.5, negative amine test, absence of key cells in smears, decrease of pathogenic microflora and increase of lactoflora.Results. On the 14th day after treatment all patients noted a significant improvement in the general condition and decrease in vaginal discharge. Clue cells were detected in only in 1 patient after treatment, accounting for 2.13% of cases. The pH of discharge in all patients was significantly decreased by the 14th day after treatment. There was a clear tendency to reduce the number of G. vaginalis, staphylococci, Mobiluncus spp., A. vaginae, Streptococcus spp. and Staphylococcus spp. and appearance of lactobacilli during treatment. Results of the study show clinical effectiveness of bacterial vaginosis therapy in 93.61% of patients, and laboratory one in 90.12%. Positive effect of therapy persisted for 1 month.Conclusion. Results of the study showed that is clindamycin (Banbact®) is an effective and optimal agent for local therapy of bacterial vaginosis in women of reproductive age. Action spectrum of the antimicrobial and antiseptic drug allows eliminating pathogenic microflora within a short period. There is no systemic effect this drug on the body.
FORMAÇÃO CONTINUADA: POSSIBILIDADES PARA A CONSTRUÇÃO DE UMA IDENTIDADE DENTRO DA PERSPECTIVA DA EDUCAÇÃO INTEGRAL
Authors: Costa Gislene Francisconi de , Camargo Gislene 
Published: December 2020

A pesquisa realizada sob o título Formação Continuada: Possibilidades para a construção de uma identidade dentro da perspectiva da Educação Integral teve por objetivo geral Analisar a percepção dos professores para a construção de uma nova identidade pedagógica do Bairro da Juventude x EMEIEF. Pe. Paulo Petruzzellis dentro da perspectiva da Educação Integral. O referencial teórico foi fundamentado nas ideias e experiências de Titton (2012 ); Tardif (2014), Brandão (2012) entre outros. A presente pesquisa possui características descritivas, com abordagem qualitativa. Foi utilizado como técnica de coletas de dados questionário estruturado. Constatamos que os questionários demostraram que os professores acreditam ser possível construir uma nova identidade pedagógica no Bairro da Juventude, envolvendo o ensino formal constituído pela escola EMEIEF. Pe. Paulo Petruzzellis, dentro da perspectiva da Educação Integral.
APRESENTAÇÃO DOSSIÊ ESTAR VIVO: APRENDER
Authors: Rigue Fernanda Monteiro , Dalmaso Alice Copetti 
Published: December 2020

O Dossiê Estar vivo: aprender, Volume 9, Número 3, da revista Criar, emerge dos desassossegos em que as situações e forças mundiais contemporâneas têm colocado a todos nós, solicitando-nos um intervalo-suspensão, convidando-nos a resingularizarmos em nós novas configurações sociais, econômicas, relacionais, educacionais, novos modos de existir. Pensamos que aí reside alguma coisa que talvez não saibamos nomear ainda, devires que tratam de processos de aprendizagens em curso, na obscuridade de não saber, afinal, o que se está aprendendo enquanto habitamos a intensa zona de indeterminação atual, verdadeiras passagens vivas, fluxos que não se pode deter, acontecimentos que chamam e perduram.Estar vivo tem sido, entre tantas coisas, um processo de aprender a ler o mundo. O que o mundo tem nos pedido, aconselhado? Como a nossa casa, as pessoas, a escola, as crianças, os velhos, a fome, as matas e os animais, as chuvas, os ventos, a doença, os vírus, a morte, músicas, obras, seres humanos e não-humanos, coisas de toda ordem e lugar, com as quais habitamos a nossa existência, tem nos convocado a entrar numa relação de aprender? Como nos tornamos capazes de responder ao que o mundo vem nos dizendo? Qual o apelo que tem chegado até nós, pedindo criações micro corporais e subjetivas de nossos gestos, palavras, ações? Como tornar matéria de expressão esse aprender indeterminado e aberto? Como, afinal, isso nos leva a dar a ver e dizer sobre educação?Concebemos o estar vivo como um processo ininterrupto de criação, fabricação de si, inesgotável potência de aprendizagem. Os ecos desses processos são por vezes silenciosos, esquecidos, invisibilizados e perturbadores, porém, carregados de potência, de uma força multifacetada de alianças impensadas com o que quer que seja. Desejamos aqui que os sons das palavras desse viver-aprender chegue como um chamado a produzir uma inédita relação de composição com as palavras, conceitos, ideias, pensamentos, seres visíveis e invisíveis que habitam os textos dos autores e autoras deste material. Assim, ainda que sozinhas/os, estaremos ativas/os, deslizando sob as fronteiras, encontrando respiros, debruçando-nos pelas bordas, criando e brincando pelas superfícies.Apostamos na co-participação, escuta e atenção com a multiplicidade de perspectivas trazidas deste Dossiê, ampliando os meandros relativos aos infinitos processos de aprendizagens que podemos testemunhar. Por fim, o Dossiê, como uma grande extensão de nosso corpo - território que sente, pensa, age, experimenta a si mesmo - deseja que os estudos e pesquisas apresentados possam mover infinitos processos, autoconstitutivos, de aprender-criar-estar-vivo, evocando, em todos nós, novas maneiras de habitar o mundo e a educação.
Pengaruh Tingkat Pengetahuan dan Stres Kerja terhadap Pencegahan Kecelakaan Kerja pada Pekerja Giling dan Ketel di PG Rejo Agung Baru Madiun
Authors: Bagus Prahartiko Caesar Kridha , Soesetijo FX Ady , Endah Yani Ristya Widi 
Published: December 2020

workers in sugar mills are prone to accident in their workplace. This research aims at disclosing the effect of knowledge level and work stress on prevention of work accident in Milled and Kettle Workers. It is a qualitative research employing analytic observation method using cross sectional design. The sample, including 115 workers in Milling and Kettle Section in PG Rejo Agung Baru Madiun, were selected by using total sampling. Regression Test by SPSS 22 was applied to analyze the data. Findings demonstrate the sig value of knowledge level indicating 0.889 and sig value of stress level of 0.027. It reveals that there is no effect from workers’ knowledge level, in contrast, work stress affect the prevention of work place accident. Therefore, more stimulation on knowledge level and support for workers are prominent to minimize their work stress.Keywords: Knowledge level, sugar mill, work accident, work stress
Efektivitas Model Problem Posing Tipe Pre-Solution Posing terhadap Kemampuan Pemecahan Masalah Matematik Siswa
Authors: Mayasari Devi , Himmah Wulan Izzatul 
Published: December 2020

<p class="06IsiAbstrak"><span lang="EN-GB">This study aims to determine the effectiveness of the problem-posing type pre-solution posing model against students' mathematical problem-solving abilities. This type of research is an experimental study with a pre-test post-test control group design. The population in this study was 256 students grade VII one of Junior High School in Salatiga in the academic year 2018/2019 divided into 8 classes. Through the cluster random sampling technique, the VIIE class students were selected as the experimental class and the VIIH class students as the control class. The technique of collecting data on mathematical problem-solving ability through pre-test and post-test. The data analysis technique used the independent sample t-test on the N-Gain score. The results showed that the application of the problem-posing type pre-solution posing more effective against students' mathematical problem-solving abilities compared to students who received conventional learning.</span></p><p class="06IsiAbstrak"><span lang="EN-GB"><br /></span></p><p class="06IsiAbstrak">Penelitian ini bertujuan untuk mengetahui efektivitas model problem posing tipe pre-solution posing terhadap kemampuan pemecahan masalah matematik siswa. Jenis penelitian ini merupakan penelitian eksperimen dengan pretest-postest control group design. Populasi dalam penelitian ini sebanyak 256 siswa kelas VII salah satu SMP di Kota Salatiga Tahun Pelajaran 2018/2019 yang terbagi dalam 8 kelas. Melalui teknik cluster random sampling, terpilih siswa kelas VIIE sebagai kelas eksperimen dan siswa kelas VIIH sebagai kelas kontrol. Teknik Pengambilan data kemampuan pemecahan masalah matematik melalui pretest dan posttest. Teknik analisis data menggunakan independent sample t-test pada N-Gain score. Hasil penelitian menunjukkan bahwa penerapan model problem posing tipe pre-solution posing lebih efektif terhadap kemampuan pemecahan masalah matematik siswa dibandingkan siswa yang mendapatkan pembelajaran secara konvensional.</p><p class="06IsiAbstrak"><span lang="EN-GB"><br /></span></p>