bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed Finite Element Analysis of 180 M Deck Cargo / Launch Barge B42
Authors: Yalchiner Fikri Bashar , Agrawal Rajender , Kamal Faris , Takieddine Oussama 
Published: November 2019

Abstract
In this study, a detailed finite element analysis methodology of a 180 m deck cargo/launch barge B42 for 32,000 MT topside load is described and results are presented. Using Finite Element Method (FEM) for large welded steel structures such as a deck cargo/launch barge has been quite challenging in past because the engineer had to observe the balance between solution accuracy and numerical efficiency. However, recent improvements in solver algorithms in FEM packages and increasing core processor numbers in computers enable engineers to include a lot more details to their FE model so that accurate stiffness and mass of the structure can be simulated. In this study, the entire barge is modelled in ANSYS Software using shell elements including longitudinal beams, stiffeners, flanges, base plates, skid tracks and outriggers.
Two most critical load cases were analyzed; the first is the maximum hogging condition which occurs in the topside loadout sequence where the topside is entirely on barge deck towards stern. The second load being the maximum sagging case where the topside is at the final location on the deck of barge for transportation.
Results of the detailed FE analysis confirmed the structural integrity of the barge showing all the stresses and displacements are below allowable limits for all load cases. Two main advantages were observed through detailed modelling of the entire barge. Firstly, a faster preprocessing time is as compared to shell-beam models. Secondly, increasing the mesh density in critical locations in global FE model will be equivalent to a sub-model in this case. Thus, eliminating the need for analyzing any detail separately.
Vector analysis of Contoura Vision for the correction of myopia and myopic astigmatism
Authors: Lin Ying , Huanjun Su , Jianbin Wu , Xia Zhang , Xi Xu , Muzhi Yuan 
Published: November 2019

Abstract
Objective: To evaluate the visual outcomes of Contoura Vision with automatic eye tracking system in eyes with myopia and myopic astigmatism.
Methods: In this prospective study, 40 consecutive patients (80 eyes) with moderate myopia and irregular astigmatism were included from January to August 2018 at Liuzhou Worker’s Hospital. Subjects were randomly divided into an experimental group (40 eyes) that underwent Contoura Vision FS-LASIK and a control group (40 eyes) that underwent wavefront-optimized FS-LASIK. Target refractions of all subjects were plano. Visual outcomes and astigmatic vector analysis were evaluated and compared between preoperatively and 3 months post-operatively.
Results: The preoperative spherical and cylindrical refractive errors were similar in both groups (P>0.05). At 3 months postoperatively, cumulative uncorrected distance visual acuity (UDVA) was 20/16, 20/20, or 20/25 in 30 %, 95%, 100 % of patients in the experimental group, respectively. The experimental group was better than the control group in predictability of astigmatism correction at 3 months after operation. In the experimental group, 80% of eyes had deviation of astigmatic axis within 15° and 35% of eyes had deviation of astigmatic axis within 5°, both were better than those in the control group. The number of eyes with residual astigmatism within 0.5D were higher in the experimental group (60%, 24 eyes) than the control group (50%, 20 eyes). Compared with the preoperative, C7 significantly reduced to 0.056±0.030 in the experimental group at 3 months after the procedure (P<0.05), and were significantly lower than those in the control group (P<0.05).
Conclusion: Contoura Vision with automatic eye tracking system was safe and effective for the correction of myopia and myopic astigmatism.
Key words: vector analysis; irregular astigmatism; Contoura Vision
Sociodemographic and Health-Related Characteristics of a Safety-Net Patient Population
Authors: Agovi Afiba Manza-Azele , Anikpo Ifedioranma , Cvitanovich Matthew J. , Yan Lu , Chu Tzu-Chun , MacDonald Brooke , Gehr Aaron W. , Craten Kevin , Ojha Rohit P. 
Published: November 2019

Abstract
ABSTRACT
Background
Safety-net health systems are an important source of healthcare for underserved or vulnerable individuals, but definitions of safety-net institutions are largely based on patient characteristics. Some definitions may not accurately identify such institutions. Therefore, we aimed to describe the characteristics of urban safety-net patients in Texas and compare the distribution of morbidities between safety-net and general population patients.
Methods
We used hospital claims data from the Dallas-Fort Worth Hospital Council Foundation to create a cross-sectional cohort. Eligible patients were aged ≥18 years and Tarrant County residents in 2018. Patients were divided into two groups for comparison. The first group represented patients with hospital claims from JPS Health Network (i.e. safety-net population). The second group represented all patients with hospital claims in Tarrant County (i.e. general population). We estimated frequencies of patient characteristics. In addition, we estimated overall and payor-stratified standardized morbidity ratios (SMRs) adjusted for age, gender, and race/ethnicity to compare the prevalence of common chronic diseases between safety-net patients and patients in the general population.
Results
Our study population comprised 459,827 patients, of whom 74,323 (16%) were safety-net patients. Patients aged ≥65 years comprised 23% of the general population and 11% of the safety-net population. Non-Hispanic Whites comprised 52% of the general population and 29% of safety-net patients. A larger proportion of safety-net patients were uninsured compared with general population patients (safety-net: 54%; general population: 25%), but Medicaid distribution was less discrepant (safety-net: 9%; general population: 7%). Medicare was the primary payor for 24% of general population patients and 14% of safety-net patients. Safety-net patients had relative excesses of mental health and chronic conditions ranging between 5% and 230% for all selected conditions except dementia/Alzheimer’s. The patterns for payor-stratified SMRs were consistent with the overall results.
Conclusions
We observed considerable sociodemographic diversity and a high burden of mental health and chronic conditions among safety-net patients, which may support understanding the healthcare needs of safety-net populations. Our findings raise questions about definitions of safety-net institutions based on Medicaid distribution alone and the transportability of findings from studies in which safety-net populations are unrepresented.
Enteric phageome alternations in Type 2 diabetes disease
Authors: Chen Qian , Ma Xiaojing , Li Chong , Shen Yun , Zhu Wei , Zhang Yan , Guo Xiaokui , Zhou Jian , Liu Chang 
Published: November 2019

Abstract
Background Type 2 diabetes (T2D) is a complex metabolic disease and has been proved to involve in the alternation of the gut microbiota. The previous studies primarily focused on the changes in bacteriome while ignoring the phage community composition. The extracellular phages could lyse the host bacteria, and thus influence the microbiota through the positive or negative interactions with bacteria. We investigated the change of extracellular phageome and explored its role in T2D pathogenesis.Results We used a sequencing-based approach to identify the bacteriophage after isolation of VLPs from the fecal samples. We identified 330 phages according to the predicted host bacteria. The phageome characteristics were highly diverse among individuals. In the T2D group, the intestinal phage population is altered and the abundance of 7 identified phages specific to Enterobacteriaceae hosts were found increased markedly. Additionally, the abundance of Enterobacteriaceae bacteria in gut was significantly increased and the systemic LPS elevation was observed in T2D group. Several phage consortia were found to have significant correlations with T2D disease indicators.Conclusions The alteration of bacteriophages predicted to infect Enterobacteriaceae in the gut was observed in this study, which was expected to be a new source of systemic LPS in T2D patients, and may contribute to the pathogenesis of the disease. The data present in this study revealed the similar variation trend in enteric bacteriome and the correlated bacteriophages, which is likely to shed considerable light on overall understanding the interactions between microbiome and metabolic diseases.
The Contribution of Stem Cell Factor and Granulocyte-Colony Stimulating Factor in Reducing Neurodegeneration and Promoting Neural Network Reorganization after Traumatic Brain Injury
Authors: He Junchi , Russell Thomas , Qiu Xuecheng , Hao Fei , Kyle Michele , Chin Lawrence , Zhao Li-Ru 
Published: November 2019

Abstract
Background Traumatic brain injury (TBI) is a major cause of death and disability in young adults worldwide. TBI-induced long-term cognitive deficits represent a growing clinical problem.Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF)play a role in neuroprotection and neuronal plasticity.However, the knowledge concerning reparative efficacy of SCF+G-CSF treatment in post-acute TBI recovery remains incomplete. This study aims to determine the effectsof stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) on post-TBI recovery in young adult mice. The controlled cortical impact model of TBI was used for inducing a severe damage in the motor cortex of the right hemisphere in 8-week-old male C57BL mice. The combination treatment of SCF and G-CSF (SCF+G-CSF) was initiated 3 weeks after induction of TBI. Results Severe TBI led to persistent motor functional deficits (Rota-Rod test) and impaired spatial learning and memory (Morris water maze test). SCF+G-CSF treatment significantly improved the severe TBI-impaired spatial learning and memory at 6 weeks post-treatment.TBI also caused significant increases of Fluoro-Jade C positive degenerating neurons in bilateral frontal cortex, striatum and hippocampus, and significant reductions in MAP2+apical dendrites and overgrowth of SMI312+axons in peri-TBI cavity frontal cortex and in the ipsilateral hippocampal CA1 at 24 weeks post-TBI. SCF+G-CSF treatment significantly reduced TBI-induced neurodegeneration in the contralateral frontal cortex and hippocampal CA1, increased MAP2+apical dendrites in the peri-TBI cavity frontal cortex, and prevented TBI-induced axonal overgrowth in both the peri-TBI cavity frontal cortex and ipsilateral hippocampal CA1. Conclusions These findings reveal a novel pathology of axonal overgrowth after TBI and demonstrate a therapeutic potential of SCF+G-CSF in ameliorating TBI-induced long-term neuronal pathology, neural network malformation, and impairments in spatial learning and memory.
Head Mild Hypothermia Inhibits the Increase of Extracellular Glutamate Concentration by Upregulating Glial Glutamate Transporter 1 During Ischemia-reperfusion Injury
Authors: Ma Dongyang , An Qi , Zhang Zhiqiang , Bian Qinghu , Li Yanan , Li Yanli , Zhang Shan 
Published: November 2019

Abstract
Background Stroke is characterized by high morbidity, high mortality and disability. Therefore, it is very important to illuminate the pathological mechanism and find effective treatment strategies. Hypothermia therapy is widely used in clinical as a neuroprotective strategy practice. However, the exact mechanism is not fully understood. Methods Four-vessel occlusion (4-VO) was used to establish animal models of global cerebral ischemia-reperfusion and nasopharyngeal cavity cooling method was used for hypothermia treatment. Extracellular fluid in hippocampal CA1 area was collected by microdialysis technology, and extracellular glutamate concentration ([Glu]e) was detected by high performance liquid chromatography (HPLC). The expression levels of glial glutamate transport-1(GLT-1), Bcl-2 and Bax at the determined time points in hippocampal CA1 area were detected by Western blotting and immunohistochemistry and histopathological evaluation was performed by thionin staining. Dihydrokainate (DHK), a GLT-1 specific inhibitor, was used to confirm the function of GLT-1 in cerebral ischemia-reperfusion injury. Results Cerebral brain ischemia-reperfusion caused the downregulation of GLT-1 and Bcl-2, the upregulation of Bax, and an increase in [Glu]e, and leaded to neuron loss. Head mild hypothermia (HMH) for 2 h applied 8min after ischemic insult attenuated the abovementioned effects of ischemia-reperfusion, while pretreatment with DHK by injection into the lateral ventricle inhibited this effect. Conclusion HMH can play a neuroprotective role by upregulating GLT-1 and reducing the excitotoxicity of Glutamate during ischemia-reperfusion insult in rats. Keywords Ischemia-reperfusion; Mild hypothermia; Glutamate transport; Neuroprotection
QTL-seq Analysis of Seed Size Trait in Grape Reveal New Insight on The Genetics of Seedlessness
Authors: Wang Li , Zhang Songlin , Jiao Chen , Li Zhi , Liu Chonghuai , Wang Xiping 
Published: November 2019

Abstract

Background Seedlessness in grape ( Vitis vinifera ) is an important commercial trait for both the fresh and drying markets. However, despite numerous studies, the mechanisms and key genes regulating grape seedlessness are mostly unknown. Results In this study, we sequenced the genomes of the V. vinifera seeded cultivar ‘Red Globe’, the seedless cultivar ‘Centennial’, as well as the derived hybrids. Nonsynonymous SNPs were identified and analyzed with respect to published transcriptome data. All the DEGs containing nonsynonymous SNPs were further analyzed in terms of expression patterns, Gene Ontology and pathway enrichment. A potential QTL region associated with seed size was characterized based on SNP indices for both seedless and seeded progeny. Expression analysis of candidate genes during ovule development in multiple seeded and seedless grape cultivars further indicates their potential function in grape seed development. Conclusion In summary, DEGs containing nonsynonymous SNPs were mainly protein kinase, transcription factors, cytochrome P450 and other factors related to seed development, which were mainly involved in biological processes like hormone balance, seed coat and endosperm development, reproductive organ development, oxidation and reduction, senescence and cell death. Based on SNP-index and expression pattern analysis, three genes were further identified as potential seedlessness-related genes. Overall the data cast light on the differences of seed development between seeded and sedless progeny in perspective of both functional variants and expression pattern,which provides valuable candidates for future functional study.
Control Study between CT Signs and Pathological Subtypes and Differentiation Degree in Lung Adenocarcinoma
Authors: Duan Lizhen , Shan Wenli , Bo Genji , Lu Guangming , Guo Lili 
Published: November 2019

Abstract
Background: To study the relationship between CT signs and pathological subtypes and differentiation degree in lung adenocarcinoma.Methods: We retrospectively reviewed 394 cases’ CT images of lung adenocarcinoma and compared the diversity of images among PIL, MIA and IAC, as well as differentiation degrees of IAC by Kruskal-Wall test and X2 test.Results: There was no statistical difference of CT sign between PIL and MIA (P＞0.05). There are statistical differences among size and density of PIL, MIA and IAC (P＜0.01); the incidences of pleura traction sign, spicule sign, lobulation sign, tumor vascular sign, bronchial cut-off sign, air bronchogram sign and cavity sign in IAC were higher than the other two groups (P＜0.05); there was no statistical difference of vacuole sign among PIL, MIA and IAC (P＞0.05). There are statistical differences among size and density of three differentiated subgroups (P＜0.01); the incidences of pleura traction sign, spicule sign, tumor vascular sign, bronchial cut-off sign and cavity sign in poorly differentiated subgroup were highest (P＜0.01); the incidence of air bronchogram sign in highly differentiated subgroup was higher than moderately and poorly differentiated subgroup while incidence of lobulation sign was the lowest in three subgroups above (P＜0.05) ; there was no statistical difference of vacuole sign among three differentiated subgroups (P＞0.05).Conclusions: CT signs of lung adenocarcinoma are closely related to pathological subtypes and differentiation degrees，which would have great value to help predict tumor types and make treatment plans in clinical.
Glucose Transporter 1 deficiency and associated conditions in children
Authors: Gamirova R. G. , Afawi Z. , Gamirova R. R. , Gorobets E. A. , Prusakov V. F. , Volgina S. Ya. 
Published: November 2019

The article reviews literature devoted to the glucose transporter type I deficiency syndrome (synonyms: GLUT1 deficiency syndrome, de Vivo disease), that is a genetically determined disease caused by pathogenic variants of the SLC2A1 gene. The insufficiency of this protein leads to the disruption of glucose delivery to the brain through the blood-brain barrier. Clinically, the syndrome is manifested by epileptic seizures (mainly as absences or myoclonic seizures), various motor disorders and psychomotor retardation starting from the early age.Early diagnosis (including molecular genetic analysis of the SLC2A1 gene) enables us to start treatment and prevent progression of the symptoms, and to provide the family with genetic consultation on the prognosis and risks for the next generations. Ketogenic diet is an effective treatment option for this pathological condition, it can lead to a regression of the clinical manifestations, especially on the early stage.
Meningitis in children of early age. Criteria for early diagnostics
Authors: Khaliullina S. V. , Anokhin V. A. , Khayertynov Kn. S. , Sagieva V. E. , Kamasheva G. R. , Alatyrev E. Yu. 
Published: November 2019

Meningitis is characterized by the prevalence of severe forms and it is often accompanied by life-threatening syndromes.Purpose. To determine the most informative clinical manifestations of meningitis in children in their first years of life to optimize early diagnosis and treatment.Materials and methods. The authors carried out a retrospective analytical study involving 47 cases of children hospitalized to the Republican Clinical Hospital for Infectious Diseases in 2014–2016. Their diagnose was based on the acute onset of the disease, characteristic clinical symptoms and the results of lumbar puncture. The laboratory diagnostics included a standard set of examinations.Results. Meningitis was diagnosed in 34 patients (72.3%), meningoencephalitis – in 13 patients (27.7%). 30 cases (63.8%) of meningitis / meningoencephalitis had a bacterial nature, and 9 cases (19.1%; p<0.01) had a viral nature. The most common bacterial pathogens of meningitis was Pneumococcus (10 cases), hemophilus bacillus (8). Str. agalactiae (6) and meningococcus (6). 38 (80.9%) patients had high febrile fever, 1005 of patients had weakness, drowsiness, changes in consciousness of varying severity, 29 patients (61.7%) had vomiting, 16 patients ( 34%) – headache, “brain” cry, 7 patients (15%) – hyperesthesia, a symptom of “mother’s hands”, 4 patients (8.5%) – forced posture, 34 patients (72.3%) had meningeal signs.Conclusion. The most significant symptoms of early diagnosis of meningitis in children are high febrile fever combined with drowsiness and retardation, vomiting without diarrhea.
Momentary radical removal of lymphangioma in children. The results of prospective cohort study in parallel groups
Authors: Nurmeev I. N. , Zykova M. A. , Mirolubov L. M. 
Published: November 2019

Lymphangioma is a benign neoplasm caused by a congenital malformation of the lymphatic vessels.Purpose. To study the possibility of momentary radical removal of lymphangioma in children based on a prospective cohort study in parallel groups.Characteristics of children and research methods. The article presents the results of treatment of 152 patients with lymphangioma, reported from the Department of Vascular Surgery of the Children’s Republican Clinical Hospital of Tatarstan. All patients were divided into 3 groups according to the applied method of treatment. The patients in Group 1 (n=95) underwent radical removal of lymphangioma, patients in Group 2 and Group 3 underwent partial removal followed by sclerotherapy of the residual cavity of the lymphangioma.Results. The authors observed relapse in 17 (11.2%) cases, 11 of these cases were observed after previous operation of complete excision (Group 1). According to the study of the distribution of relapses, there was no difference between the groups.Conclusion. Momentary radical excision of lymphangioma is implementable in 63.3% of cases. If it is impossible to remove lymphangioma completely they use partial excision and sclerotherapy of the residual cavity. The probability of relapse does not increase in case of impossibility to remove lymphangioma completely. Minimal invasive procedure is a priority of modern surgery, as it reduces surgical trauma, facilitates postoperative period and improves cosmetic result.
Pathogenetic substantiation of phlebotropic therapy for chronic venous diseases
Authors: Bogachev V. Yu. , Mansilla A. , Boldin B. V. , Rodionov S. V. , Dzhenina O. V. 
Published: November 2019

Chronic venous disease (CVD) is the most common vascular pathology that has a significant negative effect on physical and psychological health outcomes, and requires high level of public spending on healthcare. Number of CVD risk factors has been identified in recent decades, but only recently have the experts begun to discuss the role of inflammation and endothelial dysfunction. Modern knowledge enables us to identify several priority strategies and goals aimed at managing the basic pathophysiological mechanisms of the development and progression of CVD. In particular, the use of venoactive drugs, which role in enhancing vascular tone and contractility, reducing inflammation and edema and improving microcirculation and accelerating the healing of venous leg ulcers has been carefully studied and presented with positive outcomes in various publications. This review provides various pathophysiological mechanisms of the development of CVD, which present the targets for venoactive drug therapies.
Treatment of unaesthetic facial reticular veins with long-pulsed neodymium laser
Authors: Parikov M. A. , Bagdasaryan A. G. 
Published: November 2019

The article presents various techniques to treat unaesthetic facial veins, such as periorbital, temporal, reticular veins, which pass from the neck through the angle of the lower jaw up to the temporal region, etc. Particular attention is paid to the use of the transdermal long-pulsed neodymium laser; clinical examples with photographs of areas of interest that were taken before and after treatment within 1-6 months are presented. The authors describe in detail the basic principles on the use of transdermal lasers in aesthetic medicine. It is concluded that the treatment of unwanted reticular veins with the long-pulsed neodymium laser has a number of advantages compared to other treatment methods.
Combined antibacterial drug in ambulatory surgical practice with a position of clinical efficiency and drug safety
Authors: Degovtsov E. N. , Trukhan D. I. , Sulimov A. F. 
Published: November 2019

The diverse amount of therapeutic and diagnostic manipulations and the expansion of the volume of medical care provided by the surgeon at the stage of providing primary health care to patients suggests the availability of effective, safe and affordable antibacterial drugs in the arsenal of drugs used. The review considers the possibility of using the combined antibacterial drug ciprofloxacin + tinidazole in outpatient surgical practice from the standpoint of clinical efficacy and drug safety.