bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alloying of Alkali Metals with Tellurene
Authors: Jain Rishabh , Yuan Yifei , Singh Yashpal , Basu Swastik , Wang Dawei , Yang Aijun , Wang Xiaohua , Rong Mingzhe , Lee Ho Jin , Frey David , Khadka Rajan , Hundekar Prateek , Kim Sang Ouk , Han Fudong , Wang Lin‐Wang , Mitlin David , Shahbazian‐Yassar Reza , Koratkar Nikhil 
Published: December 2020

AbstractGraphite anodes offer low volumetric capacity in lithium‐ion batteries. By contrast, tellurene is expected to alloy with alkali metals with high volumetric capacity (≈2620 mAh cm−3), but to date there is no detailed study on its alloying behavior. In this work, the alloying response of a range of alkali metals (A = Li, Na, or K) with few‐layer Te is investigated. In situ transmission electron microscopy and density functional theory both indicate that Te alloys with alkali metals forming A2Te. However, the crystalline order of alloyed products varies significantly from single‐crystal (for Li2Te) to polycrystalline (for Na2Te and K2Te). Typical alloying materials lose their crystallinity when reacted with Li—the ability of Te to retain its crystallinity is therefore surprising. Simulations reveal that compared to Na or K, the migration of Li is highly “isotropic” in Te, enabling its crystallinity to be preserved. Such isotropic Li transport is made possible by Te's peculiar structure comprising chiral‐chains bound by van der Waals forces. While alloying with Na and K show poor performance, with Li, Te exhibits a stable volumetric capacity of ≈700 mAh cm−3, which is about twice the practical capacity of commercial graphite.
Targeting BCL‐2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma
Authors: Kaufman Jonathan L. , Gasparetto Cristina , Schjesvold Fredrik H. , Moreau Philippe , Touzeau Cyrille , Facon Thierry , Boise Lawrence H. , Jiang Yanwen , Yang Xiaoqing , Dunbar Fengjiao , Vishwamitra Deeksha , Unger Stefanie , Macartney Tammy , Pesko John , Yu Yao , Salem Ahmed Hamed , Ross Jeremy A. , Hong Wan‐Jen , Maciag Paulo C. , Pauff James M. , Kumar Shaji 
Published: December 2020

AbstractVenetoclax (Ven) is a selective small‐molecule inhibitor of BCL‐2 that exhibits antitumoral activity against MM cells with t(11;14) translocation. We evaluated the safety and efficacy of Ven and dexamethasone (VenDex) combination in patients with t(11;14) positive relapsed/refractory (R/R) multiple myeloma (MM). This open‐label, multicenter study had two distinct phases (phase one [P1], phase two [P2]). Patients in both phases received VenDex (oral Ven 800 mg/day + oral Dex 40 mg [20 mg for patients ≥75 years] on days 1, 8, and 15, per 21–day cycle). The primary objective of the P1 VenDex cohort was to assess safety and pharmacokinetics. Phase two further evaluated efficacy with objective response rate (ORR) and very good partial response or better. Correlative studies explored baseline BCL2 (BCL‐2) and BCL2L1 (BCL‐XL) gene expression, cytogenetics, and recurrent somatic mutations in MM. Twenty and 31 patients in P1 and P2 with t(11;14) positive translocation received VenDex. P1/P2 patients had received a median of 3/5 lines of prior therapy, and 20%/87% were refractory to daratumumab. Predominant grade 3/4 hematological adverse events (AEs) with ≥10% occurrence included lymphopenia (20%/19%), neutropenia (15%/7%), thrombocytopenia (10%/10%), and anemia (5%/16%). At a median follow‐up of 12.3/9.2 months, ORR was 60%/48%. The duration of response estimate at 12 months was 50%/61%, and the median time to progression was 12.4/10.8 months. In biomarker evaluable patients, response to VenDex was independent of concurrent del(17p) or gain(1q) and mutations in key oncogenic signaling pathways, including MAPK and NF‐kB. VenDex demonstrated efficacy and manageable safety in heavily‐pre‐treated patients with t(11;14) R/R MM.
Cardiac evaluation of patients with 22q11.2 duplication syndrome
Authors: Butensky Adam , de Rinaldis Chiara Pandolfi , Patel Shrey , Edman Sharon , Bailey Alice , McGinn Daniel E. , Zackai Elaine , Crowley T. Blaine , McDonald‐McGinn Donna M. , Min Jungwon , Goldmuntz Elizabeth 
Published: December 2020

AbstractThe 22q11.2 duplication syndrome (22q11.2DupS) is characterized by phenotypic heterogeneity, from seemingly asymptomatic to severely affected patients. Our study sought to detail the cardiac phenotype associated with 22q11.2DupS, the prevalence of aortic arch anomalies and aortic root dilation in 22q11.2DupS, and to assess how frequently new congenital heart disease (CHD) is diagnosed at outpatient cardiac evaluation following genetic diagnosis. In our cohort of 85 patients, 20.0% had CHD, with a wide range of phenotypes. Sixty‐eight patients had complete cardiac evaluations detailing aortic arch sidedness and branching pattern, of which 5 (7.4%) had an aortic arch anomaly, all of whom had concurrent intracardiac CHD. Of 53 patients without CHD who had complete cardiac evaluations, only 3 (5.7%) had evidence of aortic root dilation. Of 46 patients who underwent outpatient cardiac evaluation following diagnosis of 22q11.2DupS, only one (2.2%) was found to have CHD, an isolated bicuspid aortic valve without stenosis. Therefore, the CHD phenotype in 22q11.2DupS, when present, is heterogeneous. Aortic arch anomalies are uncommon, and no patient in our cohort had one in isolation. Isolated aortic root dilation is also uncommon. Finally, outpatient cardiac evaluation following genetic diagnosis without previously known CHD infrequently identified minor cardiac malformations.
Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
Authors: Zebbiche Zineddine , Tekin Suat , Küçükbay Hasan , Yüksel Furkan , Boumoud Boudjemaa 
Published: December 2020

AbstractNine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one‐pot, four‐component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by 1H nuclear magnetic resonance (NMR), 13C NMR, and Fourier‐transform infrared spectroscopic techniques and elemental analysis. Cell viability assays for the tested hydrazone derivatives were performed and the log IC50 values of the compounds were calculated after a 24‐h treatment. All hydrazide derivatives tested showed a promising antitumor activity against A‐2780 cells as compared with the standard drug docetaxel with a log IC50 value of 0.2200 μM (p < .05). Seven of the examined compounds (4b–e, 4g–i) showed high cytotoxic activity against A‐2780 cells as compared with the standard drug docetaxel. Whereas the log IC50 of docetaxel was 0.2200 μM for A‐2780 cells at 24 h, the IC50 values of these compounds were −0.4987, −0.4044, −0.8138, −0.3868, −0.6954, −0.4751, and 0.1809 μM, respectively. Three of the compounds, 4b, 4d, and 4i, showed high cytotoxic activity against MCF‐7 cells as compared with docetaxel (p < .05). Whereas the log IC50 of docetaxel was 0.2400 μM for MCF‐7 cells at 24 h, the log IC50 values of compounds 4b, 4d, and 4i were −0.1293, −0.1700, and 0.2459 μM, respectively.
Determination of cardiac disease biomarker by plasmonic sandwich ELISA
Authors: Wei Weirong , Tang Yinyan , He Huimin , Gopinath Subash C.B. , Wang Lingling 
Published: December 2020

AbstractAcute myocardial infarction (AMI) is the heart attack happening when the blood flow is terminated to the heart muscles. C‐reactive protein (CRP) level is raising significantly in AMI patients after the onset of symptom; also, temporal variations of CRP in plasma of AMI patient have also been found. Quantifying the concentration of CRP helps to identify the condition associated with AMI. Plasmonic enzyme‐linked immunosorbent assay (ELISA) was utilized here to identify CRP by the sandwich of aptamer and antibody. Bare‐eye CRP detection was achieved by plasmonic ELISA through the aggregation (blue color) of gold nanoparticle in the presence of CRP, whereas in the absence of CRP, it retains its red color (dispersion). Depending on the catalase presence on the ELISA surface, hydrogen peroxide (H2O2) controls gold growth and differentiates with color changes. To achieve the lowest detection limit of CRP, H2O2 (200 µM), gold seed (0.2 µM), and streptavidin–catalase (1:500) were found optimal. The detection limit was reached at 0.25 µg/mL, whereas it was 0.5 µg/mL in the CRP‐spiked serum. This method of detection system is easier to detect the levels of CRP and helps diagnosing AMI.
Spectrofluorimetric investigation for determination of sumatriptan succinate: application to tablets and spiked human plasma
Authors: Abo Zaid Mona H. , Abo El abass Samah , El‐Enany Nahed , Aly Fatma 
Published: December 2020

AbstractA simple and highly sensitive spectrofluorimetric method for the estimation of sumatriptan succinate has been investigated. The suggested method depends on the determination of the intrinsic fluorescence properties of the drug in aqueous systems at λem 350 nm following λex at 225 nm. The linearity range was 10–100 ng/ml, with a detection limit and quantitation limit of 1.2 and 3.6 ng/ml, respectively. The suggested method was sufficiently successful for determination of sumatriptan its pharmaceutical tablets as well as in spiked human plasma. Moreover, the validation parameters were determined following International Council for Harmonisation guidelines. Statistical analysis of the obtained results from the proposed and reference methods showed no significance difference between the two methods regarding accuracy and precision.
Developmental Education Redesign in Colorado
Authors: McKay Heather , Michael Suzanne 
Published: December 2020

AbstractColorado's Community College System's Trade Adjustment Assistance Community College Career Training (TAACCCT) grant facilitated and supported the state's redesign of developmental education (DE) to increase rates of student retention and completion across fifteen community colleges. This chapter presents observations about the process of transforming Colorado's DE policy and practice, challenges faced, insights about institutional change, and the role the TAACCCT grant played.
Scaling Transformative Change in America's Community Colleges Through TAACCCT
Authors: Bragg Debra D. , Richie Deborah , Kirby Catherine 
Published: December 2020

AbstractEnsuring that the federal investment in TAACCCT has a lasting legacy is important to community colleges and the nation. Exploring the notion of transformative change, this chapter describes research and development associated with the Transformative Change Initiative (TCI), including seven guiding principles to sustain and scale change in community colleges.
Pushing the Limits of Acene Chemistry: The Recent Surge of Large Acenes
Authors: Tönshoff Christina , Bettinger Holger F. 
Published: December 2020

AbstractAcenes, consisting of linearly fused benzene rings, are an important fundamental class of organic compounds with various applications. Hexacene is the largest acene that was synthesized and isolated in the 20th century. The next largest member of the acene family, heptacene, was observed in 2007 and since then significant progress in preparing acenes has been reported. Significantly larger acenes, up to undecacene, could be studied by means of low‐temperature matrix isolation spectroscopy with in situ photolytic generation, and up to dodecacene by means of on‐surface synthesis employing innovative precursors and highly defined crystalline metal surfaces under ultrahigh vacuum conditions. The review summarizes recent experimental and theoretical advances in the area of acenes that give a significantly deeper insight into the fundamental properties and nature of the electronic structure of this fascinating class of organic compounds.
Non‐coordinated and Hydrogen Bonded Phenolate Anions as One‐Electron Reducing Agents
Authors: Weitkamp Robin F. , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold 
Published: December 2020

AbstractIn this work, the syntheses of non‐coordinated electron‐rich phenolate anions via deprotonation of the corresponding alcohols with an extremely powerful perethyl tetraphosphazene base (Schwesinger base) are reported. The application of uncharged phosphazenes renders the selective preparation of anionic phenol‐phenolate and phenolate hydrates possible, which allows for the investigation of hydrogen bonding in these species. Hydrogen bonding brings about decreased redox potentials relative to the corresponding non‐coordinated phenolate anions. The latter show redox potentials of up to −0.72(1) V vs. SCE, which is comparable to that of zinc metal, thus qualifying their application as organic zinc mimics. We utilized phenolates as reducing agents for the generation of radical anions in addition to the corresponding phenoxyl radicals. A tetracyanoethylene radical anion salt was synthesized and fully characterized as a representative example. We also present the activation of sulfur hexafluoride (SF6) with phenolates in a SET reaction, in which the nature of the respective phenolate determines whether simple fluorides or pentafluorosulfanide ([SF5]−) salts are formed.
Guided Antitumoural Drugs: (Imidazol‐2‐ylidene)(L)gold(I) Complexes Seeking Cellular Targets Controlled by the Nature of Ligand L
Authors: Bär Sofia I. , Gold Madeleine , Schleser Sebastian W. , Rehm Tobias , Bär Alexander , Köhler Leonhard , Carnell Lucas R. , Biersack Bernhard , Schobert Rainer 
Published: December 2020

AbstractThree [1,3‐diethyl‐4‐(p‐methoxyphenyl)‐5‐(3,4,5‐trimethoxyphenyl)imidazol‐2‐ylidene](L)gold(I) complexes, 4 a (L=Cl), 5 a (L=PPh3), and 6 a (L=same N‐heterocyclic carbene (NHC)), and their fluorescent [4‐(anthracen‐9‐yl)‐1,3‐diethyl‐5‐phenylimidazol‐2‐ylidene](L)gold(I) analogues, 4 b, 5 b, and 6 b, respectively, were studied for their localisation and effects in cancer cells. Despite their identical NHC ligands, the last three accumulated in different compartments of melanoma cells, namely, the nucleus (4 b), mitochondria (5 b), or lysosomes (6 b). Ligand L was also more decisive for the site of accumulation than the NHC ligand because the couples 4 a/4 b, 5 a/5 b, and 6 a/6 b, carrying different NHC ligands, afforded similar results in cytotoxicity tests, and tests on targets typically found at their sites of accumulation, such as DNA in nuclei, reactive oxygen species and thioredoxin reductase in mitochondria, and lysosomal membranes. Regardless of the site of accumulation, cancer cell apoptosis was eventually induced. The concept of guiding a bioactive complex fragment to a particular subcellular target by secondary ligand L could reduce unwanted side effects.
Heat‐transfer and hydrodynamic performance investigation of graphene‐titanium dioxide composite nanofluid in micro‐heat exchangers
Authors: Serour Nourwanda M. , El‐Shazly Ahmed H. , El‐Gayar Dina A. , Nosier Shaaban A. 
Published: December 2020

AbstractNanofluids have made a breakthrough contribution toward maximizing the efficiency of heat exchangers. Consequently, graphene nanofluids have attracted significant attention, as they yield the best heat‐transfer enhancement among all nanofluids; however, graphene is highly expensive, and further studies on hybrid graphene nanofluids are required to optimize costs. Research has been performed on the performance of pure graphene nanofluids, though little has been conducted on hybrid graphene nanofluids. Therefore, we investigated the hydrodynamic and convective heat‐transfer performance of graphene‐titanium dioxide composite (GTNC) nanofluid in a micro‐heat exchanger, and compared the results with the performance of pure graphene and pure titanium dioxide nanofluids under similar conditions. Herein, we report the synthesis of GTNC using our novel green micro‐synthesis technique and the preparation of graphene, titanium dioxide, and GTNC nanofluids using a two‐step method at three concentrations (0.02~0.08 wt%) using a surfactant. Furthermore, the stability and thermo‐physical properties of nanofluids were investigated, and nanofluids were studied for their effect on the performance of a counter‐current laminar flow micro‐heat exchanger at different flow rates (Re = 750‐1460). Findings show that thermal conductivity enhancement of GTNC nanofluid and pure graphene nanofluid at the highest mass fraction (0.08%) was 25.8% and 31.6%, respectively, while the maximum enhancement of convective heat‐transfer coefficient was 64.6% and 87%, respectively. These results indicate that hybrid GTNC nanofluid showed proximate thermal performance and stability level to graphene nanofluid with 50% less graphene content, which improves the economics of the process.
Finding our true north: On languages, understanding and curriculum in Northern Ireland
Authors: Jones Sharon 
Published: December 2020

AbstractLanguage learning can open up new worlds and deepen understanding of our own. It can foster awareness of other people, other places and cultures, and bring social and educational benefits. Northern Ireland (NI) is an increasingly multilingual region that is emerging from conflict into a welcome, but fragile, peace. It faces unique uncertainties caused by Brexit, as well as the need to develop empathy in face of the COVID‐19 pandemic. Concerns have been expressed also about academic underachievement and mental health amongst its young people. Against such a background, this paper explores the current context in NI relating to languages, and curriculum policy and practice in language education. It argues that young people in NI are poorly served, and that curriculum reform with respect to languages is timely. The paper makes five key recommendations: (1) Reform of curriculum, policy and practice relating to language education in NI; (2) Introduction of statutory language learning in primary schools; (3) Investment in teacher development; (4) Valuing of linguistic diversity and plurality in curriculum policy and practice; and (5) Further practice‐based research to explore pedagogy and outcomes in language education in NI.
Chimerism evaluation in measurable residual disease‐suspected cells isolated by flow cell sorting as a reliable tool for measurable residual disease verification in acute leukemia patients after allogeneic hematopoietic stem cell transplantation
Authors: Semchenkova Alexandra , Brilliantova Varvara , Shelikhova Larisa , Zhogov Vladimir , Illarionova Olga , Mikhailova Ekaterina , Raykina Elena , Skorobogatova Elena , Novichkova Galina , Maschan Alexey , Maschan Michael , Popov Alexander 
Published: December 2020

AbstractBackgroundThe presence of minimal/measurable residual disease (MRD) before or after hematopoietic stem cell transplantation (HSCT) is known as a predictor of poor outcome in patients with acute myeloid (AML) or lymphoblastic (ALL) leukemia. When performed with multiparameter flow cytometry (MFC), assessment of residual leukemic cells after HSCT may be limited by therapy‐induced shifts in the immunophenotype (e.g., loss of surface molecules used for therapeutic targeting). However, in such cases, questionable cells can be isolated and tested for hematopoietic chimerism to clarify their origin.MethodsQuestionable cell populations were detected during the MFC‐based MRD monitoring of 52 follow‐up bone marrow samples from 37 patients diagnosed with T cell neoplasms (n =14), B cell precursor ALL (n = 16), AML (n = 7). These cells (suspected leukemic or normal) were isolated by flow cell sorting and tested for hematopoietic chimerism by RTQ‐PCR.ResultsThe origin of cells was successfully identified in 96.15% of cases (n = 50), which helped to validate the results of MFC‐based MRD monitoring.ConclusionsWe believe that a combination of MFC, cell sorting, and chimerism testing may help confirm or disprove MRD presence in complicated cases after HSCT.
Foster parent responsiveness and young children's diurnal cortisol production
Authors: Szenczy Aline K. , Bernard Kristin , Raby K. Lee , Garnett Mallory , Dozier Mary 
Published: December 2020

AbstractFoster children are at risk for dysregulated hypothalamic pituitary adrenal (HPA) axis functioning, conferring risk for negative health outcomes. Responsive parenting may support young children's HPA axis regulation; however, few studies have examined the association between responsive parenting and cortisol production among children in foster care. In a sample of 97 foster parent–child dyads, we examined whether variation in foster parent responsiveness was linked to children's waking and bedtime levels of cortisol. Children's saliva samples were collected at wake‐up and bedtime for three consecutive days. Foster parent responsiveness, as indicated by parent sensitivity, intrusiveness, and positive regard, was assessed during video‐recorded semistructured play interactions between foster parents and children. Foster parent responsiveness significantly predicted children's waking cortisol levels (β = 0.26, p = .023). Follow‐up analyses revealed that foster parent sensitivity uniquely predicted waking cortisol (β = 0.46, p = .006), over and above other dimensions of parenting, such that children with more sensitive foster parents had higher waking cortisol than children with less sensitive foster parents. The association between foster parent sensitivity and the waking‐to‐bedtime slope of cortisol across the day was nonsignificant. Findings suggest that sensitive caregiving may support foster children's healthy HPA axis functioning.
Development of exoskeleton haptic device using powder brake and constant torque spring
Authors: Nakamura Shoki , Motoi Naoki 
Published: December 2020

AbstractThis study proposes an exoskeleton haptic device using a powder brake and a constant torque spring. The powder brake can change the torque resistance in real time, and the constant torque spring can generate a constant torque. This device is of a wearable type, and is worn on the operator's hand. By combining the powder brake and the constant torque spring, it is possible to generate an arbitrary passive force on the fingertip. Because this device generates passive force alone, it has an advantage from the viewpoint of safety. The proposed device is applied to the master system to control the slave system in a virtual reality (VR) device. Consequently, the operator can perceive the contact force between the VR device and the VR object. VR object exists in VR space, and can provide the contact force with arbitrary plasticity and elasticity. The experimental results confirm the validity of the proposed system.