bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis via A3 Coupling Reaction of Anthracene‐Propargylamine as a New Scaffold for the Interaction with DNA
Authors: Ongaro Alberto , Ribaudo Giovanni , Zagotto Giuseppe , Memo Maurizio , Gianoncelli Alessandra 
Published: December 2019

AbstractA series of new anthracene‐propargylamine derivatives were obtained through an efficient synthesis based on the A3 coupling reaction. This set of planar molecules were designed to bind double stranded and G‐quadruplex DNA arrangements. Their interaction pattern of the small molecules with DNA was predicted by molecular docking and their theoretical pharmacokinetic properties were calculated, giving encouraging results in terms of drug‐likeness. The general preference for double stranded DNA suggested by docking experiments was supported by a set of electrospray ionization mass spectrometry (ESI‐MS) experiments.
Triple‐Shell Hollow CuNiFe2O4 Spheres as Heterogeneous Catalyst for Selective Oxidation of Alcohols
Authors: Khalifeh Reza , Rajabzadeh Maryam , Ebadi Amin 
Published: December 2019

AbstractThe present work demonstrates the oxidation of numerous alcohols in the presence of H2O2 using triple‐shelled CuNiFe2O4 hollow structure as a heterogeneous catalyst. The hollow spheres were characterized by SEM, EDS, TEM and XRD. Different reaction factors such as the effect of amount catalyst, various solvents and amount oxidant were checked and discussed. Moreover, catalyst also exhibits outstanding catalytic performance for the diverse alcohols. Results showed that the triple‐shelled CuNiFe2O4 hollow structure can be recycled for up to six cycles without substantial loss in catalytic activity.
Enhancing Photothermal Effect and Stability of Plasmonic Pd/Ag‐Nanosheet by Nanoassembly for Efficient Light‐Driven Catalytic Organic Hydrogenation
Authors: Zhang Jie , Li Chuanping , Xu Chen , Wang Ping , Wang Minmin , Jin Yongdong 
Published: December 2019

AbstractDue to the ability to harness surface plasmons to promote solar‐to‐chemical energy conversion, plasmonic nanoparticles with finely‐controlled structure and optical properties hold great promise for light‐activated catalysis. Herein, we prepared a strong plasmonic nanostructure, by assembling Pd/Ag nanosheets (NSs) with varied Pd/Ag ratio onto the surface of polystyrene (PS) microsphere to form a spherical nanoassembly (NAs). The as‐prepared Pd/Ag‐PS NAs showed better photothermal performance than the precursor Pd/Ag NSs of the same concentration. More importantly, the as‐prepared Pd/Ag‐PS NAs can be used to boost light‐driven organic hydrogenation reactions, in which Pd nanocomponent acts as hydrogenation reaction active sites and Pd/Ag‐NSs can convert light efficiently into heat. Under room temperature conditions, the light‐driven catalytic hydrogenation efficiency under 50 mW/cm2 full‐spectrum irradiation proved to be comparable to that of thermally (70 °C) driven reactions. Moreover, the as‐prepared Pd/Ag‐PS NAs has better photostability than Pd/Ag NSs. The results proved that the photothermal effect rather than the transfer of hot electrons is responsible for enhanced photocatalytic hydrogenation performance. The strong plasmon coupling between closely‐packed Pd/Ag NSs enhances the electromagnetic field intensity and scattering intensity and increase Vis‐NIR light trapping and high density hot spots generation, which lead to an overall better photocatalytic efficiency.
Thickness‐Dependent In‐Plane Polarization and Structural Phase Transition in van der Waals Ferroelectric CuInP2S6
Authors: Deng Jianming , Liu Yanyu , Li Mingqiang , Xu Sheng , Lun Yingzhuo , Lv Peng , Xia Tianlong , Gao Peng , Wang Xueyun , Hong Jiawang 
Published: December 2019

Abstractvan der Waals (vdW) layered materials have rather weaker interlayer bonding than the intralayer bonding, therefore the exfoliation along the stacking direction enables the achievement of monolayer or few layers vdW materials with emerging novel physical properties and functionalities. The ferroelectricity in vdW materials recently attracts renewed interest for the potential use in high‐density storage devices. With the thickness becoming thinner, the competition between the surface energy, depolarization field, and interfacial chemical bonds may give rise to the modification of ferroelectricity and crystalline structure, which has limited investigations. In this work, combining the piezoresponse force microscope scanning, contact resonance imaging, the existence of the intrinsic in‐plane polarization in vdW ferroelectrics CuInP2S6 single crystals is reported, whereas below a critical thickness between 90 and 100 nm, the in‐plane polarization disappears. The Young's modulus also shows an abrupt stiffness at the critical thickness. Based on the density functional theory calculations, these behaviors are ascribed to a structural phase transition from monoclinic to trigonal structure, which is further verified by transmission electron microscope technique. These findings demonstrate the foundational importance of structural phase transition for enhancing the rich functionality and broad utility of vdW ferroelectrics.
A video‐based gait disturbance assessment tool for diagnosing idiopathic normal pressure hydrocephalus
Authors: Liao Ruochen , Makihara Yasushi , Muramatsu Daigo , Mitsugami Ikuhisa , Yagi Yasushi , Yoshiyama Kenji , Kazui Hiroaki , Takeda Masatoshi 
Published: December 2019

AbstractGait is an important factor in the diagnosis of idiopathic normal pressure hydrocephalus. However, except for walking speed tests, existing diagnosis methods only assess gait qualitatively. This study proposes a quantitative and multifaceted method to assess gait disturbance via video‐based analysis. We captured videos of patients walking from the front to assess four gait disturbance qualities: lateral sway, petit‐pas gait, wide‐base gait, and duck‐footed walking. These features were selected from the Gait Status Scale‐Revised, an existing scale of idiopathic normal pressure hydrocephalus gait disturbance. We confirmed that our assessments of all selected items, except for lateral sway, were consistent with physician assessment. We also used the P‐value of the gait disturbance scores before and after lumbar puncture to assess the outcome of the cerebrospinal fluid tap test, and confirmed that tap‐positive and tap‐negative patients were successfully separated by a threshold of P = 0.01. © 2019 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Cardamonin induces immune responses and enhances survival rate in WEHI‐3 cell–generated mouse leukemia in vivo
Authors: Liao Nien‐Chieh , Shih Yung‐Luen , Ho Ming‐Tak , Lu Tai‐Jung , Lee Ching‐Hsiao , Peng Shu‐Fen , Leu Sy‐Jye , Chung Jing‐Gung 
Published: December 2019

AbstractCardamonin, a monomeric alkaloid, is isolated from Alpinia conchigera Griff and other natural plants. Recently, it has been focused on its anticancer activities, and no information showing its immune effects on leukemia mice was reported. In this study, we investigated the immune effects of cardamonin on WEHI‐3 cell–generated leukemia mice. Forty BALB/c mice were randomly divided into four groups: Group I mice were normal animals and groups II‐IV were leukemia. Group II mice, as a positive control, were administered with normal diet, and group III and IV mice were treated with 1 and 5 mg/kg of cardamonin, respectively, by intraperitoneal injection every 2 days for 14 days. The population of white blood cells, macrophage phagocytosis, and the proliferations of T and B cells were analyzed by flow cytometry. Another forty mice were also separated randomly into four groups for the determination of survival rate. Results showed that cardamonin did not affect body weight. Cardamonin decreased CD3, CD11b, and Mac‐3 cell populations but increased CD19 number. Cardamonin enhanced phagocytic abilities of macrophages from the peripheral blood mononuclear cells of leukemia mice. Furthermore, cardamonin at 1 mg/kg treatment improved the survival rate of leukemia mice in vivo. Therefore, cardamonin could be applied for a leukemia therapeutic reagent at a defined dose.
Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells
Authors: Yang Si , Shao Shuxin , Huang Boshu , Yang Dan , Zeng Lin , Gan Yu , Long Dingxin , Chen Jiaxiang , Wang Jinglei 
Published: December 2019

AbstractTri‐ortho‐cresyl phosphate (TOCP), a widely used plasticizer in industry, can cause female reproductive damage. Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress. However, the reproductive protection of TPs in TOCP‐induced female reproductive system damage is yet to be elucidated. In the study, TOCP inhibited cell viability and induced autophagy of mouse ovarian granulosa cells; while TPs could rescue the inhibition of viability and induction of autophagy. 3‐MA, an autophagy inhibitor, could also rescue the inhibition of cell viability. These results indicated that TPs played a protective role in TOCP‐induced autophagy. Furthermore, TPs could inhibit the induction of oxidative stress of the cells by TOCP, which implying that TPs might alleviate TOCP‐induced autophagy via inhibiting oxidative stress. Furthermore, TPs could rescue TOCP‐induced autophagy and oxidative stress in the mouse ovarian tissues. Taken together, these results indicated that TPs could protect TOCP‐induced ovarian damage via inhibiting oxidative stress.
Responsible Innovation in Business
Authors: Jarmai Katharina , Tharani Adele , Nwafor Caroline 
Published: December 2019

AbstractThis chapter introduces responsible innovation in a business context. The first part explains the basic terms that constitute responsible innovation from a business perspective. The second part presents tangible business practices that operationalise responsible innovation and introduces two good practice examples that hint at the variety of ways in which responsible innovation can be implemented in companies.
Investigating the patient acceptable symptom state cut-offs: longitudinal data from a community cohort using the shoulder pain and disability index
Authors: Tran Gui , Dube Bright , Kingsbury Sarah R. , Tennant Alan , Conaghan Philip G. , Hensor Elizabeth M. A. 
Published: December 2019

AbstractThis prospective study aimed to determine the patient acceptable symptom state (PASS) cut-off for the patient reported outcome measure shoulder pain and disability index (SPADI), and evaluate predictors of PASS achievement following standard shoulder care. Patients with shoulder pain, referred for shoulder ultrasound were recruited from a community cohort. Patients completed both SPADI (scored 0–130) and a question on symptom state and followed-up at 6 months. PASS was calculated from Rasch-transformed scores using 2 methods: the 75th percentile of the cumulative response curve and the receiver operating characteristic curve (ROC). Logistic regression was used to identify factors associated with PASS. 304 participants (169 females, mean age 57.2 years) were included. At 6 months, 193 (63%) reported PASS. The association between SPADI at 6 months and PASS depended on baseline SPADI (interaction p = 0.036). Those with higher baseline scores had higher 6 months PASS cut-offs. Using the 75th percentile method, the 6 months total SPADI cut-off was 49.2 in those starting in the highest tertile at baseline compared to 39.4 in the lowest tertile: 46.4 vs. 36.7 for pain, 46.8 vs. 25.1 for disability. The ROC method yielded similar results. We have shown for the first time that the PASS cut-off for SPADI is dependent on baseline severity scores. Understanding the SPADI PASS threshold is important for clinical research to allow standardised reporting of shoulder intervention success at the patient level.
Large-scale volumetric flow visualization of the unsteady wake of a flapping-wing micro air vehicle
Authors: Martínez Gallar B. , van Oudheusden B. W. , Sciacchitano A. , Karásek M. 
Published: December 2019

Abstract
The objective of this experimental investigation is the volumetric visualization of the near wake topology of the vortex structures generated by a flapping-wing micro air vehicle. To achieve the required visualization domain (which in the present experiments amounts to a size of 60,000 cm3), use is made of robotic particle image velocimetry, which implements coaxial illumination and imaging in combination with the use of helium-filled soap bubbles as tracer particles. Particle trajectories are determined via Lagrangian particle tracking and information of different phases throughout the flapping cycle is obtained by means of a phase-averaging procedure applied to the particle tracks. Experiments have been performed at different settings (flow speed, flapping frequency, and body angle) that are representative of actual flight conditions, and the effect of reduced frequency on the wake topology is investigated. Furthermore, experiments have been carried out in both tethered and free-flight conditions, allowing an unprecedented comparison between the aerodynamics of the two conditions.

Graphic abstract
Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis
Authors: van der Hoek-Snieders Hanneke E. M. , van den Heuvel Antonius J. M. L. , van Os-Medendorp Harmieke , Kamalski Digna M. A. 
Published: December 2019

AbstractThis systematic review aims to determine the diagnostic accuracy of fetal MRI for detecting cleft palate in fetuses at risk for orofacial clefts. Pubmed, Embase, and CINAHL were searched systematically. A diagnostic study was included if it performed MRI (index test) and postnatal examination (reference test) in fetuses at risk for orofacial clefts. Methodological quality was assessed using the QUADAS-2. A meta-analysis was performed with a random-effects model, calculating the pooled sensitivity, specificity, and area under the curve. The search resulted in eight studies (334 fetuses) to be included: four prospective and four retrospective studies. The applicability concern was low. There was, however, a risk of selection and information bias. All studies showed that MRI well predicted the chance of cleft palate. The sensitivity results were homogeneous, but heterogeneity was assumed regarding the specificity estimate (Cochrane’s Q test: p = 0.00). The pooled sensitivity was 0.97 (95% CI 0.93–0.99); the pooled specificity was 0.94 (0.89–0.97). The area under the curve was 0.98 (95% CI 0.98–0.99).Conclusion: This meta-analysis shows that MRI has an excellent sensitivity and good to excellent specificity for diagnosing cleft palate in fetuses at risk for orofacial clefts. Future research should assess applicability for clinical care.What is Known:• Using ultrasound for prenatal detection of cleft palate leads to misdiagnosis frequently.• MRI could potentially improve the prenatal detection rate of cleft palate.What is New:• Eight studies describe the diagnostic accuracy of MRI for detecting cleft palate.• Combined results show excellent sensitivity and good to excellent specificity.
Binomial nomenclature for virus species: a consultation
Authors: Siddell Stuart G. , Walker Peter J. , Lefkowitz Elliot J. , Mushegian Arcady R. , Dutilh Bas E. , Harrach Balázs , Harrison Robert L. , Junglen Sandra , Knowles Nick J. , Kropinski Andrew M. , Krupovic Mart , Kuhn Jens H. , Nibert Max L. , Rubino Luisa , Sabanadzovic Sead , Simmonds Peter , Varsani Arvind , Zerbini Francisco Murilo , Davison Andrew J. 
Published: December 2019

AbstractThe Executive Committee of the International Committee on Taxonomy of Viruses (ICTV) recognizes the need for a standardized nomenclature for virus species. This article sets out the case for establishing a binomial nomenclature and presents the advantages and disadvantages of different naming formats. The Executive Committee understands that adopting a binomial system would have major practical consequences, and invites comments from the virology community before making any decisions to change the existing nomenclature. The Executive Committee will take account of these comments in deciding whether to approve a standardized binomial system at its next meeting in October 2020. Note that this system would relate only to the formal names of virus species and not to the names of viruses.
A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
Authors: Bruurmijn Mark L.C.M. , Schellekens Wouter , Raemaekers Mathijs A.H. , Ramsey Nick F. 
Published: December 2019

AbstractFor some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, or if one needs to compare the left and right hemisphere in the same subject. Here we propose a new standard representation, building upon existing normalization methods: Cgrid (Cartesian geometric representation with isometric dimensions). Cgrid is based on imposing a Cartesian grid over a cortical region of interest that is bounded by anatomical (atlas-based) landmarks. We applied this new representation to the sensorimotor cortex and we evaluated its performance by studying the similarity of activation patterns for hand, foot and tongue movements between subjects, and similarity between hemispheres within subjects. The Cgrid similarities were benchmarked against the similarities of activation patterns when transformed into standard MNI space using SPM, and to similarities from FreeSurfer’s surface-based normalization. For both between-subject and between-hemisphere comparisons, similarity scores in Cgrid were high, similar to those from FreeSurfer normalization and higher than similarity scores from SPM’s MNI normalization. This indicates that Cgrid allows for a straightforward way of representing and comparing sensorimotor activity patterns across subjects and between hemispheres of the same subjects.
Common set of weights and efficiency improvement on the basis of separation vector in two-stage network data envelopment analysis
Authors: Kiaei Hamid , Kazemi Matin Reza 
Published: December 2019

AbstractCommon set of weights (CSWs) method is one of the popular ranking methods in DEA which can rank efficient and inefficient units. Based on an identical criterion, the method selects the most favorable weight set for all units. An important issue is that in most common DEA models, the internal structure of the production units is ignored and the units are often considered as black boxes. In this paper, in order to evaluate the units and subunits in the two-stage NDEA based on an identical criterion, it is suggested to use CSWs method on the basis of separation vector. Our research contribution in this paper includes: (1) CSWs method is formulated in two-stage NDEA as a multiple objective fractional programming (MOFP) problem. (2) A method is suggested based on separation vector to change MOFP problem into single objective linear programming (SOLP) problem in two-stage NDEA. In the theorem, it is shown that the obtained solutions from MOFP and SOLP in two-stage NDEA are identical. (3) In the framework of the new models of two-stage NDEA, a process is introduced to improve efficiency evaluation by CSWs on the basis of separation vector which is based on the radial improvement of inputs and final outputs. Finally, an enlightening application is presented.
Photo-assisted Catalytic Removal of NOx Over La1–xPrxCoO3/Palygorskite Nanocomposites: Role of Pr Doping
Authors: Wei Kenian , Yan Xiangyu , Zuo Shixiang , Zhu Wei , Wu Fengqin , Li Xiazhang , Yao Chao , Liu Xiaoheng 
Published: December 2019

AbstractPhoto-assisted selective catalytic reduction (photo-SCR) has been considered as a promising strategy for NOx removal in recent decades. The purpose of the present work was to test the effectiveness of La1–xPrxCoO3, supported on the surface of natural palygorskite (Pal) by a facile sol-gel method, as a photo-SCR for the removal of NOx from wastewaters. The structure, acidity, and the redox property of the prepared La1–xPrxCoO3/Pal nanocomposite were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-Visible diffuse reflectance spectroscopy (UV-Vis DRS), and X-ray photoelectron spectroscopy (XPS). Density functional theory (DFT) calculations were employed to determine the valence bands. The La1–xPrxCoO3/Pal catalysts were then tested for SCR removal of NOx with the assistance of photo-irradiation. The photo-SCR results revealed that the NOx conversion and the N2-selectivity were greatly improved by this method and reached >95% when carried out at the relatively low temperature of 200°C and with the Pr doping at x = 0.5. The improvements were attributed to the co-precipitation of a PrCoO3 phase as in a solid solution forming a coherent heterojunction of PrCoO3/La0.5Pr0.5CoO3 on the Pal surface.
Laparoscopic sleeve gastrectomy with transit loop bi-partition: A novel bariatric procedure
Authors: Mohamed Abdulla Ismaeel , Bucheeri Marwan Mohamed , Abulsel Abdulmenem Yahya , Jose Beta 
Published: December 2019

ABSTRACT

Introduction:
Obesity is a major health problem facing the Kingdom of Bahrain. Surgical interventions have proven to be the most effective modalities for the management of morbid obesity. Sleeve gastrectomy with transit loop bipartition is a novel bariatric procedure proposed to manage this condition.

Methods:
A retrospective cohort study was conducted amongst the patients who underwent bariatric surgery in our institute. Patients who underwent a laparoscopic sleeve gastrectomy (SG), One Anastomosis Gastric Bypass (OAGB) and Sleeve Gastrectomy with Transit Loop Bipartition (SG + TB) were compared to each other in intervals over a period of 1 year.

Results:
177 patients were included in this study. 104 patients had a SG, 34 patients had SG + TB and 39 patients had OAGB. The SG + TB group showed the largest reduction in average BMI with a drop of 24.5 kg/m2 over a period of a year compared to 18 and 15.4 kg/m2 in the OAGB and SG groups respectively. The OAGB group had the highest rate of resolution of diabetes mellitus (83.3%) and hypertension (81.2%) over a year. The SG + TB group had the highest rate of resolution in dyslipidemia (76.9%) & sleep apnea (96.9%). The highest rate of complications was encountered with the SG + TB group at 26.5% mostly attributed to malnutrition & hypoalbuminema.

Conclusion:
SG + TB are a novel bariatric procedure with good results in achieving weight loss and resolving comorbidities. More studies are required to fine tune the surgical techniques, limb lengths and establish the procedure's safety profile and effectiveness.

Highlights: