bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Gated MoS2 Memtransistor Crossbar Array
Authors: Lee Hong‐Sub , Sangwan Vinod K. , Rojas William A. Gaviria , Bergeron Hadallia , Jeong Hye Yun , Yuan Jiangtan , Su Katherine , Hersam Mark C. 
Published: September 2020

AbstractMemristive systems offer biomimetic functions that are being actively explored for energy‐efficient neuromorphic circuits. In addition to providing ultimate geometric scaling limits, 2D semiconductors enable unique gate‐tunable responses including the recent realization of hybrid memristor and transistor devices known as memtransistors. In particular, monolayer MoS2 memtransistors exhibit nonvolatile memristive switching where the resistance of each state is modulated by a gate terminal. Here, further control over the memtransistor neuromorphic response through the introduction of a second gate terminal is gained. The resulting dual‐gated memtransistors allow tunability over the learning rate for non‐Hebbian training where the long‐term potentiation and depression synaptic behavior is dictated by gate biases during the reading and writing processes. Furthermore, the electrostatic control provided by dual gates provides a compact solution to the sneak current problem in traditional memristor crossbar arrays. In this manner, dual gating facilitates the full utilization and integration of memtransistor functionality in highly scaled crossbar circuits. Furthermore, the tunability of long‐term potentiation yields improved linearity and symmetry of weight update rules that are utilized in simulated artificial neural networks to achieve a 94% recognition rate of hand‐written digits.
Modification Engineering in SnO2 Electron Transport Layer toward Perovskite Solar Cells: Efficiency and Stability
Authors: Deng Kaimo , Chen Qinghua , Li Liang 
Published: September 2020

AbstractThe electron transport layer plays a key role in affecting the charge dynamics and photovoltaic parameters in perovskite solar cells. Compared to other counterparts, SnO2 has unique advantages such as low temperature fabrication and high electron extraction ability, and it receives extra attentions from the research community since the first report. Planar‐type perovskite solar cells based on SnO2 exhibit a simple architecture and state of art device can achieve a power conversion efficiency of over 23%, which can compete with traditional devices using mesoporous TiO2. The modification engineering of SnO2 has contributed significantly to the enhanced device performance during the past years. There is still great potential for further improvement in the efficiency and long‐term stability. Herein recent advances toward modifying the optoelectronic properties of SnO2 from the perspective of the optimization strategies are summarized and the remaining challenges as well as opportunities for future research are discussed. The continuous efforts dedicated to this exciting field may pave the way for developing commercial perovskite solar cells.
Progress Report on Property, Preparation, and Application of Bi2O2Se
Authors: Sun Yuan , Zhang Jing , Ye Shuai , Song Jun , Qu Junle 
Published: September 2020

AbstractThe study of 2D materials has been a significant and fascinating area, at least since the discovery of graphene. As one of the layered bismuth oxychalcogenides, bismuth oxyselenide (Bi2O2Se) has drawn a lot of attention recently. The study of Bi2O2Se was mainly focused on its thermoelectric performance until its ultrathin 2D structure came to the fore. New physical properties of Bi2O2Se were discovered along with the successful synthesis of 2D Bi2O2Se structures. Few‐layer Bi2O2Se exhibits ultrahigh mobility, outstanding stability, tunable bandgaps, and excellent mechanical properties, showing remarkable performance in electronics and optoelectronics. In this report, an overview of recent advances in Bi2O2Se research is provided, including structure/property modifications, synthetic methods, and practical applications. Theoretical and experimental results on bulk/few‐layer Bi2O2Se are both discussed in this report. Finally, the challenges and outlook for Bi2O2Se are evaluated based on current progress.
Enhancement of Triboelectric Charge Density by Chemical Functionalization
Authors: Liu Yanhua , Mo Jilong , Fu Qiu , Lu Yanxu , Zhang Ni , Wang Shuangfei , Nie Shuangxi 
Published: September 2020

AbstractA triboelectric nanogenerator (TENG) can convert energy in the surrounding environment to electricity. Therefore, in recent years, research related to TENGs has significantly increased owing to its simple and low‐cost manufacturing process, high portability, and high efficiency. The principle of the TENG lies in the coupling effect of contact electrification and electrostatic induction. Its output performance is directly proportional to the square of the surface charge density, which is related to friction materials. To increase the output power of a TENG and continuously provide electricity for other electronic equipment, many scholars have conducted detailed studies on the triboelectric properties of materials. Particularly, there has been research interest in the chemical functionalization of TENGs due to their unique advantages, such as high triboelectric charge density, durability, stability, and self‐cleaning properties. This Progress Report highlights the research progress in chemical modification methods for improving the charge density of TENGs, and classifies their modification methods according to their mechanisms. The effects of chemical reaction, surface chemical treatment, and chemical substance doping on the output performance of TENGs are systematically elaborated. Furthermore, the applications of chemically modified TENG in self‐powered sensors and emerging fields, including wearable electronic devices, human‐machine interfaces, and implantable electronic devices, are introduced. Lastly, the challenges faced in the future developments of chemical modification methods are discussed, thereby guiding researchers to the use of chemical modification methods for the improvement of charge density for further exploration.
Metal–Organic Frameworks Based on Group 3 and 4 Metals
Authors: Feng Liang , Pang Jiandong , She Ping , Li Jia‐Luo , Qin Jun‐Sheng , Du Dong‐Ying , Zhou Hong‐Cai 
Published: September 2020

AbstractMetal–organic frameworks (MOFs) based on group 3 and 4 metals are considered as the most promising MOFs for varying practical applications including water adsorption, carbon conversion, and biomedical applications. The relatively strong coordination bonds and versatile coordination modes within these MOFs endow the framework with high chemical stability, diverse structures and topologies, and interesting properties and functions. Herein, the significant progress made on this series of MOFs since 2018 is summarized and an update on the current status and future trends on the structural design of robust MOFs with high connectivity is provided. Cluster chemistry involving Y, lanthanides (Ln, from La to Lu), actinides (An, from Ac to Lr), Ti, and Zr is initially introduced. This is followed by a review of recently developed MOFs based on group 3 and 4 metals with their structures discussed based on the types of inorganic or organic building blocks. The novel properties and arising applications of these MOFs in catalysis, adsorption and separation, delivery, and sensing are highlighted. Overall, this review is expected to provide a timely summary on MOFs based on group 3 and 4 metals, which shall guide the future discovery and development of stable and functional MOFs for practical applications.
Haploidentical vs matched unrelated donor transplantation for acute myeloid leukemia in remission: A prospective comparative study
Authors: Cho Byung‐Sik , Min Gi‐June , Park Silvia , Park Sung‐Soo , Shin Seung‐Hwan , Yahng Seung‐Ah , Jeon Young‐Woo , Yoon Jae‐Ho , Lee Sung‐Eun , Eom Ki‐Seong , Kim Yoo‐Jin , Lee Seok , Min Chang‐Ki , Cho Seok‐Goo , Kim Dong‐Wook , Lee Jong Wook , Kim Myungshin , Kim Yonggoo , Kim Hee‐Je 
Published: September 2020

AbstractDespite comparable outcomes of haploidentical transplants (Haplo‐HSCT) with HLA‐matched unrelated transplants (MUD‐HSCT) in retrospective comparisons, few studies have prospectively compared Haplo‐HSCT with MUD‐HSCT in AML. Here, we prospectively compared the outcomes of Haplo‐HSCT with MUD‐HSCT for AML in remission (n = 110) to prove non‐inferiority of overall survival in Haplo‐HSCT. Both groups were well balanced in factors related to biological features of AML and measurable residual disease (MRD) status by Wilms' tumor gene 1 (WT1) assay. A unique, reduced‐toxicity preparative regimen was used for Haplo‐HSCT, whereas mostly‐myeloablative regimen was for MUD‐HSCT. Both groups showed similar patterns of neutrophil and platelet recovery, whereas delayed T‐cell reconstitution in Haplo‐HSCT was found compared with MUD‐HSCT. No significant differences were found in acute or chronic graft‐vs‐host‐disease (GVHD) and post‐transplant infectious events with an exception of EBV or CMV infection, which occurred more frequently in Haplo‐HSCT. After a median follow‐up of 47 months, no significant differences in overall survival (65% vs 54%, P = .146), disease‐free survival (67% vs 53%, P = .142), relapse (20% vs 21%, P = .858), non‐relapse mortality (14% vs 26%, P = .103), or GVHD‐free/relapse‐free survival (54% vs 41%, P = .138) were observed for Haplo‐HSCT vs MUD‐HSCT. In multivariate analysis, WT1 expression before transplantation independently predicted relapse, resulting in inferior survival. Separate analysis of unenrolled patients (n = 110) who were excluded or refused to participate in this study showed consistent results with enrolled patients. This prospective study demonstrated the non‐inferiority of Haplo‐HSCT to MUD‐HSCT for AML in remission, and validated the role of WT1 quantification as an MRD marker (ClinicalTrial.gov identifier: NCT01751997).
Large Magnetic Anisotropy Energy and Robust Half‐Metallic Ferromagnetism in 2D MnXSe4 (X = As, Sb)
Authors: Hu Tengfei , Wan Wenhui , Li Yingmei , Ge Yanfeng , Zhang Kaicheng , Liu Yong 
Published: September 2020

AbstractIn recent years, intrinsic 2D magnetism has aroused great interest because of its potential application in spintronic devices. However, low Curie temperature (Tc) and magnetic anisotropy energy (MAE) limit its application prospects. Here, using first‐principles calculations based on density‐functional theory, a series of stable MnXSe4 (X=As, Sb) single‐layer is predicted. The MAE of single‐layer MnAsSe4 and MnSbSe4 is 648.76 and 808.95 eV per Mn atom, respectively. Monte Carlo simulations suggest the Tc of single‐layer MnAsSe4 and MnSbSe4 is 174 and 250 K, respectively. The energy band calculation with hybrid Heyd–Scuseria–Ernzerhof (HSE06) function indicates the MnXSe4 (X = As, Sb) is ferromagnetic half‐metallic. Also, it has 100% spin‐polarization ratio at the Fermi level. For MnAsSe4 and MnSbSe4, the spin‐gaps are 1.59 and 1.48 eV, respectively. These excellent magnetic properties render MnXSe4 (X = As, Sb) as promising candidate materials for 2D spintronic applications.
Prevalence and severity of long‐term physical, emotional, and cognitive fatigue across 15 different cancer entities
Authors: Schmidt Martina E. , Hermann Silke , Arndt Volker , Steindorf Karen 
Published: September 2020

AbstractBackgroundFatigue prevalence and severity have been assessed in a variety of studies, yet, not in a standardized way, and predominantly in breast cancer patients. Systematic, comparative investigations across a broad range of cancer entities are lacking.MethodsThe FiX study systematically enrolled 2244 cancer patients across 15 entities approximately 2 years after diagnosis. Fatigue was assessed with the multidimensional EORTC QLQ‐FA12 questionnaire. Physical, emotional, cognitive, and total fatigue were compared across entities and with normative values of the general population. Differences in patients' characteristics and cancer therapy between entities were taken into account using analyses of covariance models.ResultsAcross all entities, mean physical fatigue levels were significantly higher than age‐ and sex‐matched means of the general population for all cancer entities (all Bonferroni‐Holm adjusted P < .01). For most entities also emotional and cognitive fatigue levels were significantly higher than normative values. Age‐ and sex‐standardized physical fatigue prevalence ranged from 31.8% among prostate to 51.7% among liver cancer patients. Differences between entities could not be fully explained by sex, age, BMI, or cancer therapy. Adjusted for these factors, mean physical fatigue was higher for stomach (P = .0004), lung (P = .034), kidney (P = .0011), pancreas (P = .081), and endometrium (P = .022) compared to breast cancer patients. Adjusted means of emotional fatigue were also lowest in breast cancer patients and significantly higher in stomach (P = .0047), bladder (P = .0036), and rectal (P = .0020) cancer patients.ConclusionsPhysical, emotional, and cognitive fatigue is prevalent in all 15 investigated cancer entities even 2 years after diagnosis. Fatigue in breast cancer patients, the so‐far most studied group, is in the lowest range among all entities, suggesting that the extent of fatigue is still insufficiently determined. Entity‐specific problems might need to be considered in the treatment of fatigue.
The Identification of Anthocyanins from Padus racemosa and Its Protective Effects on H2O2‐Induced INS‐1 Cells Damage and STZ‐Induced Diabetes Mice
Authors: Liu Jianli , Tian Siqi , Xin Chong , Liu Jia , Wang Qiuyu , He Yin , Liu Meijia , Fu Mingyang , Yang Yang , Cao Xiangyu 
Published: September 2020

AbstractOxidative damage in cells induced by reactive oxygen species (ROS) is a main factor in diabetes mellitus diseases progression. The composition of anthocyanins from Padus racemosa (APR) and the protective effects of APR on H2O2‐induced rat insulinoma (INS‐1) cells damage and streptozocin (STZ)‐induced diabetes mice were investigated in this study. The main components of APR were cyanidin‐cyanidin glucosyl‐rutinoside, cyanidin‐cyanidin xylosyl‐rutinoside, cyanidin‐xylosyl‐glucoside and cyanidin‐rutinoside, which were determined by liquid chromatography‐mass spectrometry (LC/MS). APR could scavenge the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), hydroxyl radical and superoxide radical in vitro. ROS level was decreased and the cell viability was increased in INS‐1 cells after treated with APR. Cell apoptosis induced by H2O2 in INS‐1 cells was decreased after incubation with APR. APR could decrease the phosphorylation of p38 and the nuclear translocation of p65, which indicated that APR could inhibit the activation of p38 Mitogen‐activated protein kinase (MAPK) and Nuclear factor kappa B (NF‐κB) cell signaling pathways. Meanwhile, APR could effectively reduce the blood glucose and blood lipid in STZ‐induced diabetic mice. These results suggested that APR might be a potential agent for diabetes mellitus diseases treatment.
Usefulness of oral anticoagulation in patients with coronary aneurysms: Insights from the CAAR registry
Authors: D'Ascenzo Fabrizio , Saglietto Andrea , Ramakrishna Harish , Andreis Alessandro , Jiménez‐Mazuecos Jesús M. , Nombela‐Franco Luis , Cerrato Enrico , Liebetrau Christoph , Alfonso‐Rodríguez Emilio , Bagur Rodrigo , Alkhouli Mohamad , De Ferrari Gaetano M. , Núñez‐Gil Iván J. ,   The CAAR Investigators
Published: September 2020

AbstractObjectivesTo assess the Usefulness of oral anticoagulation therapy (OAT) in patients with coronary artery aneurysm (CAA).BackgroundData on the most adequate antithrombotic CAA management is lacking.MethodsPatients included in CAAR (Coronary Artery Aneurysm Registry, Clinical Trials.gov: NCT02563626) were selected. Patients were divided in OAT and non‐OAT groups, according to anticoagulation status at discharge and 2:1 propensity score matching with replacement was performed. The primary endpoint of the analysis was a composite and mutual exclusive endpoint of myocardial infarction, unstable angina (UA), and aneurysm thrombosis (coronary ischemic endpoint). Net adverse clinical events, major adverse cardiovascular events, their single components, cardiovascular death, re‐hospitalizations for heart failure, stroke, aneurysm thrombosis, and bleeding were the secondary ones.ResultsOne thousand three hundred thirty‐one patients were discharged without OAT and 211 with OAT. In the propensity‐matched sample (390 patients in the non‐OAT group, 195 patients in the OAT group), after 3 years of median follow‐up (interquartile range 1–6 years), the rate of the primary endpoint (coronary ischemic endpoint) was significantly less in the OAT group as compared to non‐OAT group (8.7 vs. 17.2%, respectively; p = .01), driven by a significant reduction in UA (4.6 vs. 10%, p < .01) and aneurysm thrombosis (0 vs. 3.1%, p = .03), along with a non‐significant reduction in MI (4.1 vs. 7.7%, p = .13). A non‐significant increase in bleedings, mainly BARC type 1 (55%), was found in the OAT‐group (10.3% in the non‐OAT vs. 6.2% in the OAT group, p = .08).ConclusionOAT decreases the composite endpoint of UA, myocardial infarction, and aneurysm thrombosis in patients with CAA, despite a non‐significant higher risk of bleeding.
Low‐Temperature, Ambient Pressure Oxidation of Methane to Methanol Over Every Tri‐Iron Node in a Metal–Organic Framework Material
Authors: Hall Jacklyn N. , Bollini Praveen 
Published: September 2020

AbstractIn contrast with metal‐modified zeolites, metal–organic framework materials (MOFs) provide a platform that may be significantly more amenable to creating catalysts in which every metal site is endowed with the same coordination environment, and hence, catalytic function. Using MIL‐100(Fe) as a prototype, we present the first example of a synthetic heterogeneous catalyst comprised exclusively of active tri‐iron moieties participating in the low‐temperature oxidation of methane to methanol; in contrast with prior reports on iron‐MOFs, we report the near‐exclusive formation of methanol at low temperatures and sub‐ambient methane pressures, and evidence its effectuation solely by Fe2+ sites. The study captures the utility of exploring classes of materials endowed with a high level of definition in structure and catalytic function for the purposes of overcoming persistent scientific and technological challenges in the field of synthetic heterogeneous catalysis.
Aromatic Foldamer Helices as α‐Helix Extended Surface Mimetics
Authors: Zwillinger Márton , Reddy Post Sai , Wicher Barbara , Mandal Pradeep K. , Csékei Márton , Fischer Lucile , Kotschy András , Huc Ivan 
Published: September 2020

AbstractHelically folded aromatic oligoamide foldamers have a size and geometrical parameters very distinct from those of α‐helices and are not obvious candidates for α‐helix mimicry. Nevertheless, they offer multiple sites for attaching side chains. It was found that some arrays of side chains at the surface of an aromatic helix make it possible to mimic extended α‐helical surfaces. Synthetic methods were developed to produce quinoline monomers suitably functionalized for solid phase synthesis. A dodecamer was prepared. Its crystal structure validated the initial design and showed helix bundling involving the α‐helix‐like interface. These results open up new uses of aromatic helices to recognize protein surfaces and to program helix bundling in water.
The Structures of Gd(III) Chelates Conjugated at the Periphery of 3‐(1’‐Hexyloxy)ethyl‐3‐devinylpyropheophorbide‐a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer
Authors: Zhang Shunqing , Cheruku Ravindra R. , Dukh Mykhaylo , Tabaczynski Walter , Patel Nayan J. , White William H. , Missert Joseph R. , Spernyak Joseph A. , Pandey Ravindra K. 
Published: September 2020

Abstract3‐(1’‐Hexyloxyethyl)‐3‐devinyl‐pyropheophorbide‐a (HPPH or Photochlor), a tumor‐avid chlorophyll‐a derivative currently undergoing human clinical trials, was conjugated at various peripheral positions (position‐17 or 20) of HPPH with either Gd(III)‐aminobenzyl‐DTPA (Gd(III) DTPA) or Gd(III)‐aminoethylamido‐DOTA (Gd(III) DOTA). The corresponding conjugates were evaluated for in vitro PDT efficacy, T1, T2 relaxivities, in vivo fluorescence, and MR imaging under similar treatment parameters. Among these analogs, the water‐soluble Gd(III)‐aminoethylamido‐DOTA linked at position‐17 of HPPH, i. e., HPPH‐17‐Gd(III) DOTA, demonstrated strong potential for tumor imaging by both MR and fluorescence, while maintaining the PDT efficacy in BALB/c mice bearing Colon‐26 tumors (7/10 mice were tumor free on day 60). In contrast to Gd(III) DTPA (Magnevist) and Gd(III) DOTA (Dotarem), the HPPH‐Gd(III) DOTA retains in the tumor for a long period of time (24 to 48 h) and provides an option of fluorescence‐guided cancer therapy. Thus, a single agent can be used for cancer‐imaging and therapy. However, further detailed pharmacokinetic, pharmacodynamic, and toxicological studies of the conjugate are required before initiating Phase I human clinical trials.
14‐Color single tube for flow cytometric characterization of CD5+ B‐LPDs and high sensitivity automated minimal residual disease quantitation of CLL/SLL
Authors: Goshaw Jennifer M. , Gao Qi , Wardrope Jessica , Dogan Ahmet , Roshal Mikhail 
Published: September 2020

AbstractIntroductionThe diagnosis of CLL/SLL relies on flow cytometric immunophenotyping. Increasing emphasis is being placed on precise detection of the minimal residual disease. Following antigen recommendations of ERIC and ESCCA's Harmonization Project, we validated a 14‐color assay for the characterization CD5+ lymphoproliferative neoplasms and CLL MRD with a sensitivity of at least 10−4.MethodsThe assay was designed based on ERIC/ESCCA recommended antigens with the addition of CD40 for alternate gating when CD19 expression is reduced. Lower limit of quantitation/lower limit of detection, assay procedural precision, linearity, and limit of blank were established. Then, 52 CD5+ B‐cell lymphoproliferative neoplasms (41 CLL/11 non‐CLL) and 29 normal samples were used for parallel evaluation. Automated cluster identification and quantitation of CLL clones in MRD setting was performed using Barned‐Hutt SNE. Separation analysis between CLL and non‐CLL phenotypes was performed by PCA and bh‐SNE.ResultsSeparation ratios for each antigen exceeded ERIC/ESCCA guidelines. Precision was <20% at LLOQ (0.01%). The limit of blank was <10/500,000 cells. Concordance between the 14‐color and legacy assay (Deming regression y = 1.01x, r2 = .99) was seen. All 20 samples with MRD levels 0.5%–0.006% (median 0.04%) showed an abnormal cell cluster by bh‐SNE, with concordant results between manual and automated quantitation (y = x, r2 = 1). CLL cases clustered together and away from mantle cell lymphoma by bh‐SNE and PCA with outlier atypical phenotype CLL cases posing diagnostic challenges by both manual and automated analysis.ConclusionThe 14‐color CD5+ LPD assay provides a robust standardization platform for MRD and disease characterization using both manual and automated analysis.