bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inverse modeling constrained by potential field data, petrophysics, and improved geologic mapping: A case study from prospective northwest Tasmania
Authors: Eshaghi Esmaeil , Reading Anya M. , Roach Michael , Duffett Mark , Bombardieri Daniel , Cracknell Matthew J. , Everard John L. , Cumming Grace , Kuhn Stephen 
Published: June 2020

The Heazlewood-Luina-Waratah area is a prospective region for minerals in northwest Tasmania, Australia, associated with historically important ore deposits related to the emplacement of granite intrusions and/or ultramafic complexes. The geology of the area is poorly understood due to the difficult terrain and dense vegetation. We have constructed an initial high-resolution 3D geologic model of this area using constraints from geologic maps and geologic and geophysical cross sections. This initial model is improved upon by integrating results from 3D geometry and physical property inversion of potential field (gravity and magnetic) data, petrophysical measurements, and updated field mapping. Geometry inversion reveals that the Devonian granites in the south are thicker than previously thought, possibly connecting to deep sources of mineralization. In addition, we identified gravity anomalies to the northeast that could be caused by near-surface granite cupolas. A newly discovered ultramafic complex linking the Heazlewood and Mount Stewart Ultramafic Complexes in the southwest also has been modeled. This implies a greater volume of ultramafic material in the Cambrian successions and points to a larger obducted component than previously thought. The newly inferred granite cupolas and ultramafic complexes are targets for future mineral exploration. Petrophysical property inversion reveals a high degree of variation in these properties within the ultramafic complexes indicating a variable degree of serpentinization. Sensitivity tests suggest maximum depths of 2–3 km for the contact aureole that surrounds major granitic intrusions in the southeast, whereas the Heazlewood River complex is likely to have a deeper source up to 4 km. We have demonstrated the value of adding geologic and petrophysical constraints to 3D modeling for the purpose of guiding mineral exploration. This is particularly important for the refinement of geologic structures in tectonically complex areas that have lithology units with contrasting magnetic and density characteristics.
Rational approximation of P-wave kinematics — Part 1: Transversely isotropic media
Authors: Abedi Mohammad Mahdi 
Published: June 2020

In seismic data processing and several wave propagation modeling algorithms, the phase velocity, group velocity, and traveltime equations are essential. To have these equations in explicit form, or to reduce algebraic complexity, approximation methods are used. For the approximation of P-wave kinematics in acoustic transversely isotropic media, we have developed a new flexible 2D functional equation in a continued fraction form. Using different orders of the continued fraction, we obtain different approximations for (1) phase velocity as a function of phase direction, (2) group velocity as a function of group direction, and (3) traveltime as a function of offset. Then, we use them in the approximation of the group direction as a function of phase direction, and phase direction as a function of group direction. The proposed approximations have a rational form, which is considered algebraically simple and computationally efficient. The used continued fraction form rapidly converges to exact kinematics. By introducing the optimal ray into our approximations and using it for parameter definition, the convergence becomes faster, so the accuracy of the existing most accurate approximations is available by the third order, and new most accurate approximations are obtained by the fourth order of the proposed general form. The error of the most accurate version of the proposed approximations is below 0.001% for moderate anisotropic models with an anellipticity parameter up to 0.3. This high accuracy is considered to be attractive in practical implementations that use the kinematic equations and their derivatives.
Direct differentiation of cord blood derived mesenchymal stem cells into keratinocytes without feeder layers and cAMP inducers
Authors: Ghauri Ayesha Kashmala , Wahid Mohsin , Mirza Talat , Ainuddin Jahan Ara 
Published: June 2020

Objectives: The purpose of our study was isolation of umbilical cord blood derived mesenchymal stem (UCB-MSCs), their direct differentiation towards keratinocytes without using feeder layers, cAMP inducers and hormones known for morphological maintenance and proliferation of keratinocytes and characterization of UCB-MSCs through flowcytometry and keratinocytes through immunofluorescence.
Methods: We have isolated and cultured UCB-MSCs (n=4) following critical parameters for successful isolation like sample processing within an hour of collection, gestational age not more than 38 weeks, no co-morbid and blood volume at least 80 ml. Cord blood mononuclear cells were isolated through ficoll based density-gradient centrifugation then cultured to isolate MSCs, defined by minimum criteria of International Society for Cellular Therapy. UCB-MSCs were then differentiated directly into keratinocytes. Differentiation was confirmed by morphology and characterized through immunofluorescence staining. UCB samples were collected from gynae/obstetric ward of OJHA campus under sterile conditions and processed at Stem cells and Regenerative medicine Lab, Dow Research Institute of Biotechnology and Biomedical Sciences, Ojha campus. The total duration of study was approximately 12 months.
Results: We have successfully isolated UCB-MSCs that were plastic adherent, spindle shaped, showed trilineage mesodermal differentiation potential and were positive for CD90, CD73 and CD105 and negative for CD34 markers. UCB-MSCs were directly differentiated towards keratinocytes without using cAMP inducers, hormones or feeder layers. Differentiated keratinocytes attained typical honeycomb morphology and were stained positive on immunofluorescence for anti-pan cytokeratin antibody.
Conclusion: Our study concludes possibility of direct differentiation of isolated and cultured UCB-MSCs into keratinocytes without using feeder layers and conventional keratinocyte culture media.
doi: https://doi.org/10.12669/pjms.36.5.1566
How to cite this:Ghauri AK, Wahid M, Mirza T, Uddin JAA. Direct differentiation of cord blood derived mesenchymal stem cells into keratinocytes without feeder layers and cAMP inducers. Pak J Med Sci. 2020;36(5):946-951. doi: https://doi.org/10.12669/pjms.36.5.1566
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fetomaternal outcome in patients with placenta previa
Authors: Wasim Tayyiba , Bushra Natasha , Riaz Saher , Iqbal Hafiza Iqra 
Published: June 2020

Objectives: To assess maternal and fetal morbidity associated with placenta previa and morbidly adherent placenta (MAP).
Methods: All patients with placenta previa who delivered in services hospital from April 1, 2017 to March 31, 2019 were included. Maternal and fetal outcomes were compared amongst patients with placenta previa and MAP.
Results: Total of 8002 patients delivered with 152 (1.9%)diagnosed as placenta previa and 56 (36.8%) amongst them had MAP. One hundred thirty-one out of One hundred fifty-two (86.1%) of our patients were booked. Increased number of caesarean section, multi parity and anterior placenta had significant association with MAP (p<0.0001). Maternal morbidity in terms of postpartum hemorrhage >2000ml, caesarean hysterectomy, number of blood transfusions, bladder injury, need for ICU admission was significantly more in patients with MAP (p<0.0001). Case fatality was 3% with two maternal deaths in MAP and none in placenta previa. Fetal outcome was good in both groups as gestational age at delivery was 36 weeks or more, birth weight was ≥ 2.5 kg and >6 APGAR score (p<0.05). Two neonatal deaths occurred in MAP and one in placenta previa owing to prematurity.
Conclusion: MAP is a dreadful complication of placenta previa with increased maternal morbidity. Regular antenatal care with adequate arrangement of blood transfusion and multidisciplinary approach can reduce maternal mortality.
doi: https://doi.org/10.12669/pjms.36.5.1647
How to cite this:Wasim T, Bushra N, Riaz S, Iqbal HI. Fetomaternal outcome in patients with placenta previa. Pak J Med Sci. 2020;36(5):952-957. doi: https://doi.org/10.12669/pjms.36.5.1647
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Challenges faced by the Medical Editors in COVID19 Pandemic era
Authors: Jawaid Shaukat Ali , Jawaid Masood 
Published: June 2020

doi: https://doi.org/10.12669/pjms.36.5.3009
How to cite this:Jawaid SA, Jawaid M. Challenges faced by the Medical Editors in COVID19 Pandemic era. Pak J Med Sci. 2020;36(5):855-856. doi: https://doi.org/10.12669/pjms.36.5.3009
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Artificial intelligence in medical education: Are we ready for it?
Authors: Imran Nazish , Jawaid Masood 
Published: June 2020

doi: https://doi.org/10.12669/pjms.36.5.3042
How to cite this:Imran N, Jawaid M. Artificial intelligence in medical education: Are we ready for it? Pak J Med Sci. 2020;36(5):857-859. doi: https://doi.org/10.12669/pjms.36.5.3042
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Estudio descriptivo de dos herramientas de cribado de riesgo nutricional al ingreso hospitalario en el sanatorio Allende de Argentina
Authors: González Victoria Carolina , Antequera María Elena , Álvarez Vizzoni Romina , Fernández Natalia , Iglesias Eugenia 
Published: June 2020

Introducción: El objetivo de este estudio fue comparar dos herramientas de cribado nutricional, Nutritional Risk Screening 2002 (NRS-2002) y Fase de Filtro Nutricional Analítico (FILNUT), sobre una muestra de pacientes al ingreso hospitalario, analizar la prevalencia de riesgo nutricional, evaluar la concordancia entre ambos y su validez para identificar pacientes en riesgo.Material y métodos: Estudio descriptivo, transversal, donde se evaluaron 271 pacientes admitidos dentro de las primeras 72 horas, con el método NRS-2002 utilizado como gold standard y la herramienta FILNUT. Se utilizó el Test de Chi2 para la asociación estadística entre los distintos métodos y la concordancia fue estudiada a través del índice kappa. La precisión se evaluó mediante sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo, y razón de verosimilitud. La validez de los test de cribado nutricional para identificar pacientes en riesgo, se analizó mediante la comparación de curvas ROC con cálculo del área bajo la curva (AUC).Resultados: La prevalencia de pacientes en riesgo nutricional fue 61% con FILNUT y 31% con NRS-2002. El método FILNUT con una alta sensibilidad (92,8%), deja un gran número de falso positivos por su baja especificidad (53,3%). La concordancia entre ambos métodos fue aceptable (Kappa=0,37). Mediante la curva ROC, se comprobó que los test de cribado fueron válidos para identificar pacientes en riesgo: FILNUT AUC = 0,999 (IC 95% 0,963-0,100); NRS-2002 AUC = 0,708 (IC 95% 0,643-0,767).Conclusiones: El método FILNUT es una herramienta de cribado válida que reveló mayor prevalencia de riesgo nutricional y con alta sensibilidad descartó apropiadamente a aquellos pacientes sin riesgo. Al comparar ambas herramientas, FILNUT incorpora el uso de prealbúmina, cuyos bajos valores deberían considerarse como potencial riesgo nutricional. Por otra parte, su escaso factor tiempo y costos directos en su realización, lo avalan como herramienta eficiente. La simplicidad y facilidad requerida para su realización contrastan con el NRS-2002 que requiere de personal capacitado.
Correlations between Laboratory Dynamic CBR and Compaction Parameters of Unbound Coarse Aggregate for Base Courses
Authors: Kuttah Dina 
Published: June 2020

Abstract
It is well known that the determination of fundamental engineering properties of materials is the key to their inclusion within quality control assessments and pavement design. Although using of maximum dry density and optimum moisture content has been widely accepted in quality control assessments, it may not provide the mechanistic properties of the compacted material, namely, strength or stiffness. On the other hand, the static plate loading test used for quality control of roads is relatively expensive as compared with lighter equipment used nowadays to control the bearing capacity of compacted unbound materials. In this context, it has become necessary to find a simple and quick test that can be used in assessing the bearing capacity of Swedish base course material. For this purpose, several unbound granular California bearing ratio (CBR) samples were prepared and compacted using modified Proctor compaction for a wide range of molding water contents. Then, the CBR samples have been tested by a dynamic California bearing ratio device. This research provides a data base for future adopting of the dynamic CBR test as a light equipment used for quality assurance during roads construction. Regression equations have been developed to predict the laboratory dynamic CBR (CBRLD) from the molding water contents and the dry densities with relatively high correlation coefficients. These equations can be used in predicting the CBRLD values for unbound granular materials compacted and tested at similar conditions as in that developed for.
Comparison of the Structure and Properties of the Solid Co-Cr-W-Mo-Si Alloys Used for Dental Restorations CNC Machined or Selective Laser-Sintered
Authors: Dobrzański Lech B. , Achtelik-Franczak Anna , Dobrzańska Joanna , Dobrzański Leszek A. 
Published: June 2020

AbstractThe purpose of this paper is to compare the impact of selective laser-sintering (SLS) technology and computer numerical control (CNC) machining methods on the structure and properties of solid Co-Cr-W-Mo-Si alloys. Structural tests were carried out using x-ray structural analysis; energy-dispersive x-ray spectroscopy chemical composition analysis; metallographic investigations using stereoscopic, light, and scanning electron microscopes using computerized methods of quantitative metallography; and tests of tensile, bending, and compression strength. Individually designed microsamples were used, and the results were statistically processed. It was shown that if optimal conditions of SLS technology are used, it is possible to obtain a structure with a pore content of 0.1 % smaller than in the case of solid cast materials. This ensures better mechanical properties than cast materials. At the same time, it was pointed out that even minor technological errors associated with SLS technology caused a lowering of all strength properties associated with a significant increase in porosity by up to 10 %. Allowing small changes in technological conditions, including the width of the laser spot, the width of the laser beam, the allowance associated with the overlap of the laser beam, disturbances in the flow of inert gas, and uncontrolled changes in the laser power, can cause a significant reduction in strength. A plug and play approach is unacceptable. If even one layer with a thickness of 25 μm is produced in suboptimal conditions, the manufactured element cannot meet the assumed requirements. The use of SLS additive technology for the production of prosthetic components made of Co-Cr alloys is the best choice among the methods currently used in dentistry. The use of SLS technology together with the digitization of design and manufacturing processes is an important element in implementing the Dentistry 4.0 approach as part of the Industry 4.0 stage of the industrial revolution.
The Galaxy, National Literature, and Reconstruction
Authors: Thomas Brook 
Published: June 2020

Brook Thomas, “The Galaxy, National Literature, and Reconstruction” (pp. 50–81)
The North’s victory in the Civil War preserved the Union and led to the abolition of slavery. Reconstruction was a contentious debate about what sort of nation that union of states should become. Published during Reconstruction before being taken over by the Atlantic Monthly, the Galaxy tried, in Rebecca Harding Davis’s words, to be “a national magazine in which the current of thought of every section could find expression.” The Galaxy published literature and criticism as well as political, sociological, and economic essays. Its editors were moderates who aesthetically promoted a national literature and politically promoted reconciliation between Northern and Southern whites along with fair treatment for freedmen. What fair treatment entailed was debated in its pages. Essayists included Horace Greeley, the abolitionist journalist; Edward A. Pollard, author of The Lost Cause (1866); and David Croly, who pejoratively coined the phrase “miscegenation.” Literary contributors included Davis, Walt Whitman, Henry James, Mark Twain, Constance Fenimore Woolson, John William De Forest, Julian Hawthorne, Emma Lazarus, Paul Hayne, Sidney Lanier, and Joaquin Miller. Juxtaposing some of the Galaxy’s literary works with its debates over how the Union should be reimagined points to the neglected role that Reconstruction politics played in the institutionalization of American literary studies. Whitman is especially important. Reading the great poet of American democracy in the context of the Galaxy reveals how his postbellum celebration of a united nation—North, South, East, and West—aligns him with moderate views on Reconstruction that today seem racially reactionary.
Acquisitive Liaisons
Authors: Kuczynski Sarah Anne 
Published: June 2020

Sarah Anne Kuczynski, “Acquisitive Liaisons: Collecting and Alternative Valuing in Harold Frederic’s The Damnation of Theron Ware” (pp. 82–109)
This essay reads Harold Frederic’s The Damnation of Theron Ware (1896) as an attempt to reimagine human relationships amid the unsettling of traditional, effortful methods for establishing personal value amid the socioeconomic stratification of Gilded Age America. Foregrounding the novel’s imbrication within late-nineteenth-century America’s “collecting mania,” this study contends that the relationship that forms between the Octavius elite and the title character closely resembles that between collector and recent acquisition. The idea that Theron is treated as an object by Celia and her friends might appear to lend support to the prevailing reading of the novel as a tale about a naive young minister who is used and abused by the worldly figures he idolizes. However, I offer a contrarian challenge to this dominant interpretation by demonstrating that Theron, in fact, consistently pursues objecthood and the fate of acquisition over the course of the novel—not in a masochistic sense but because, as this essay argues, within the Gilded Age social world of The Damnation of Theron Ware, the life of a prized possession has the potential to be a fulfilling one. Theron may talk of his grand plans for renovating his character but in reality he seizes every opportunity to retreat to a space where passivity is encouraged, where personal value is assigned rather than earned or enacted.
Closing Human Reference Genome Gaps: Identifying and Characterizing Gap-Closing Sequences
Authors: Zhao Tingting , Duan Zhongqu , Genchev Georgi Z , Lu Hui 
Published: June 2020

Abstract
Despite continuous updates of the human reference genome, there are still hundreds of unresolved gaps which account for about 5% of the total sequence length. Given the availability of whole genome de novo assemblies, especially those derived from long-read sequencing data, gap-closing sequences can be determined. By comparing 17 de novo long-read sequencing assemblies with the human reference genome, we identified a total of 1,125 gap-closing sequences for 132 (16.9% of 783) gaps and added up to 2.2 Mb novel sequences to the human reference genome. More than 90% of the non-redundant sequences could be verified by unmapped reads from the Simons Genome Diversity Project dataset. In addition, 15.6% of the non-reference sequences were found in at least one of four non-human primate genomes. We further demonstrated that the non-redundant sequences had high content of simple repeats and satellite sequences. Moreover, 43 (32.6%) of the 132 closed gaps were shown to be polymorphic; such sequences may play an important biological role and can be useful in the investigation of human genetic diversity.
Development and Validation of an Open Access SNP Array for Nile Tilapia (Oreochromis niloticus)
Authors: Peñaloza Carolina , Robledo Diego , Barría Agustin , Trịnh Trọng Quốc , Mahmuddin Mahirah , Wiener Pamela , Benzie John A H , Houston Ross D 
Published: June 2020

AbstractTilapia are among the most important farmed fish species worldwide, and are fundamental for the food security of many developing countries. Several genetically improved Nile tilapia (Oreochromis niloticus) strains exist, such as the iconic Genetically Improved Farmed Tilapia (GIFT), and breeding programs typically follow classical pedigree-based selection. The use of genome-wide single-nucleotide polymorphism (SNP) data can enable an understanding of the genetic architecture of economically important traits and the acceleration of genetic gain via genomic selection. Due to the global importance and diversity of Nile tilapia, an open access SNP array would be beneficial for aquaculture research and production. In the current study, a ∼65K SNP array was designed based on SNPs discovered from whole-genome sequence data from a GIFT breeding nucleus population and the overlap with SNP datasets from wild fish populations and several other farmed Nile tilapia strains. The SNP array was applied to clearly distinguish between different tilapia populations across Asia and Africa, with at least ∼30,000 SNPs segregating in each of the diverse population samples tested. It is anticipated that this SNP array will be an enabling tool for population genetics and tilapia breeding research, facilitating consistency and comparison of results across studies.