bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholder perception of reverse logistics practices on supply chain performance
Authors: Pushpamali NNC , Agdas Duzgun , Rose Timothy M. , Yigitcanlar Tan 
Published: August 2020

AbstractManaging supply chain performance is essential for value generation to stakeholders. Nonetheless, this process has become overly complicated due to environmental concerns that lead to policy changes, customer preferences, and business activities. Reverse logistics is an environmentally friendly practice that can be critical in improving the environmental performance of construction operations. This paper examines the perceived role of reverse logistics practices on supply chain performance criteria—for example, cost, quality, time, flexibility, and environment. Semistructured in‐depth interviews were conducted with 15 senior industry experts from South East Queensland, Australia. Interview transcripts were analyzed by coding, categorizing, and identifying the interconnected relationships among concepts. In general, the experts perceive that reverse logistics practices significantly reduce the sourcing cost of materials compared with new materials. When used materials meet industry specifications, they are expected to have a similar performance without affecting the construction time or the overall quality of the project while protecting the environment. Nevertheless, the flexibility is found to be somewhat difficult. It is likely that reverse logistics can be instrumental in construction should the industry uptake be substantial with an emphasis on used material quality and acceptance criteria. Hence, a quantitative analysis is encouraged for future research.
Retracted: SLCO4A1‐AS1 promotes cell growth and induces resistance in lung adenocarcinoma by modulating miR‐4701‐5p/NFE2L1 axis to activate WNT pathway
Authors: Wei Yuxuan , Wei Li , Li Jiwei , Ma Zeheng , Zhang Quan , Han Zhijun , Li Saisai 
Published: August 2020

AbstractLong noncoding RNAs (lncRNAs) possessed essential functions in the biological behaviors of various human cancers. SLCO4A1 antisense RNA 1 (SLCO4A1‐AS1) is a lncRNA that has been reported as a oncogenic regulator in colorectal cancer and bladder cancer. However, whether it exerted functions in the gene expression and cellular processes in lung adenocarcinoma (LUAD) remains still obscure. In the present research, we unveiled the high level of SLCO4A1‐AS1 in LUAD tissues and cells. Moreover, functional assays indicated that SLCO4A‐AS1 facilitated LUAD cell proliferation, motility, and cisplatin‐resistance. Besides, mechanism investigation revealed that miR‐4701‐5p could interact with SLCO4A1‐AS1 and directly target to NFE2L1. The expression correlation between miR‐4701‐5p and SLCO4A1‐AS1 or NFE2L1 was found to be negative. Moreover, NFE2L1 was expressed at a same tendency with SLCO4A1‐AS1 in LUAD tissues and cells. In addition, it was confirmed that NFE2L1 was involved in SLCO4A1‐AS1‐mediated activation of WNT pathway. According to rescue assays, NFE2L1 could involve in SLCO4A1‐AS1‐mediated LUAD cell growth. Conclusively, our study demonstrated that SLCO4A1‐AS1 facilitated cell growth and enhanced the resistance of LUAD cells to chemotherapy via activating WNT pathway through miR‐4701‐5p/NFE2L1 axis.
Delayed initiation of adjuvant chemotherapy in older women with breast cancer
Authors: Smith‐Graziani Demetria , Lei Xiudong , Giordano Sharon H. , Zhao Hui , Karuturi Meghan , Chavez‐MacGregor Mariana 
Published: August 2020

AbstractBackgroundAdjuvant chemotherapy benefits early‐stage breast cancer (BC) patients. Older women receive guideline‐adherent treatment less frequently and experience treatment delays more frequently. We evaluated factors associated with delaying adjuvant chemotherapy and the delays’ survival impact in a large population–based cohort of elderly BC patients.MethodsPatients age >66 years diagnosed 2001‐2015 with localized or regional BC were identified in the SEER‐Medicare and Texas Cancer Registry‐Medicare databases. Time from surgery to chemotherapy (TTC) was categorized into four groups: 0‐30, 31‐60, 61‐90, and >90 days. We identified predictors of delays, estimated overall (OS) and BC‐specific (BCSS) survival, and determined the association between TTC and outcome adjusting for other variables.ResultsAmong 28,968 women (median age 71 years), median TTC was 43 days. 10.7% of patients experienced TTC >90 days. Older age, Black or Hispanic race/ethnicity, unmarried status, more comorbidities, hormone receptor‐positivity, mastectomy, Oncotype DX testing, and full state buy‐in were associated with increased risk of delay. Five‐year OS estimates by TTC group were 0.82, 0.81, 0.80, and 0.74, respectively (p<.001). BCSS demonstrated a similar trend (p<.001). Chemotherapy delay was associated with worse OS (HR=1.33, 95%CI 1.25‐1.40) and BCSS (HR=1.39, 95%CI 1.27‐1.53). In subgroup analysis, delayed chemotherapy was associated with worse OS and BCSS among patients with hormone receptor–positive (HR=1.56, 95%CI 0.97‐2.51), HER2‐positive (HR=1.99, 95%CI 1.04‐3.79), and triple‐negative (HR=2.15, 95%CI 1.38‐3.36) tumors.ConclusionChemotherapy delays are associated with worse survival in older BC patients. Providers should avoid delays and initiate chemotherapy ≤90 days after surgery regardless of patients’ BC subtype or age.
Apoptosis‐inducing factor deficient mice fail to develop hepatic steatosis under high fat high fructose diet or bile duct ligation
Authors: Sahu Parul , Mohan K. Varsha , Aggarwal Savera , Arindkar Shailendra , Mahesh Kumar Jerald , Kumar Upadhyay Pramod , Ramakrishna Gayatri , Nagarajan Perumal 
Published: August 2020

Apoptosis‐inducing factor (AIF) is a mitochondrial flavoprotein involved in redox signalling and programmed cell death. The role of AIF has been well recognized in diabetes and obesity. However, the aspect of AIF deficiency in the development of hepatic steatosis and liver injury is unknown. Therefore, in the current study, Harlequin (Hq mutant) mouse with markedly reduced content of AIF was investigated to explore the role of AIF on the initiation of liver injury. The wild type (WT) developed physiological and pathological features of non‐alcoholic fatty liver disease (NAFLD) that were not seen in the Hq mice with AIF deficiency, when fed on high fat high fructose (HFHF) diet. Following bile duct ligation (BDL), the liver associated pathological changes were less conspicuous in Hq mice as compared to WT mice. The expression of AIF protein and apoptosis was markedly lesser as compared to their respective control in Hq mice on HFHF diet. Furthermore, the genes involved in fatty acid metabolism were also altered in the group of treated Hq mice. In conclusion, Hq mice failed to develop diet induced hepatic steatosis, suggestive of a role of AIF mediated pathway in the initiation and progression of liver inflammation. Thus, partial loss of AIF appears to be hepatoprotective.Significance of the studyAIF deficiency has multiple roles in altered pathology processes and cellular metabolism, thereby compromising the cellular homeostasis. Considering the molecular functions of AIF in other organ pathology little is known about its role in diet induced liver injury. Hence, the aim of the current study was to investigate the role of AIF deficiency in liver injury and diseases with focus on NAFLD. The study will help to deliniate the mechanisms of NAFLD using Harliquin Mice.
Insight into the Electrooxidation Mechanism of Ethylene Glycol on Palladium‐Based Nanocatalysts: In Situ FTIRS and LC‐MS Analysis
Authors: Da Silva Rodrigo Garcia , Rodrigues de Andrade Adalgisa , Servat Karine , Morais Cláudia , Napporn Teko W. , Kokoh Kouakou B. 
Published: August 2020

AbstractThe ethylene glycol oxidation reaction on nickel and ruthenium modified palladium nanocatalysts was investigated with electrochemical, spectroelectrochemical, and chromatographic methods. These carbon‐supported materials, prepared by a revisited polyol approach, exhibited high activity towards the ethylene glycol electrooxidation in alkaline medium. Electrolysis coupled with high performance liquid chromatography/mass spectrometry (HPLC‐MS) and in situ Fourier transform infrared spectroscopy (FTIRS) measurements allowed us to determine the different compounds electrogenerated in the oxidative conversion of this two‐carbon molecule. High value‐added products such as oxalate, glyoxylate, and glycolate were identified in all electrolytic solutions, whereas glyoxylate was selectively formed at the Ru45@Pd55/C electrode surface. In situ FTIRS results also showed a decrease in the pH value in the thin layer near the electrode as a consequence of OH− consumption during the spectroelectrochemical experiments.
The Missing Link in the Magnetism of Hybrid Cobalt Layered Hydroxides: The Odd–Even Effect of the Organic Spacer
Authors: Oestreicher Víctor , Hunt Diego , Dolle Christian , Borovik Paula , Jobbágy Matías , Abellán Gonzalo , Coronado Eugenio 
Published: August 2020

AbstractA dramatic change in the magnetic behaviour, which solely depends on the parity of the organic linker molecules, has been found in a family of layered CoII hydroxides covalently functionalized with dicarboxylic molecules. These layered hybrid materials have been synthesized at room temperature using a one‐pot procedure through the epoxide route. While hybrids connected by odd alkyl chains exhibit coercive fields (Hc) below ca. 3500 Oe and show spontaneous magnetization at temperatures (TM) below 20 K, hybrids functionalized with even alkyl chains behave as hard magnets with Hc>5500 Oe and display a TM higher than 55 K. This intriguing behaviour was studied by density functional theory with the incorporation of a Hubbard term (DFT+U) calculations, unveiling the structural subtleties underlying this observation. Indeed, the different molecular orientation exhibited by the even/odd alkyl chains, and the orientation of the covalently linked carboxylic groups modify the intensity of the magnetic coupling of both octahedral and tetrahedral in‐plane sublattices, thus strongly affecting the magnetic properties of the hybrid. These findings offer an outstanding level of tuning in the molecular design of hybrid magnetic materials based on layered hydroxides.
Simulation of Methanol and Urea Production from Catalytic Conversion of Steel Mill Gases
Authors: Schlüter Stefan , Geitner Christian 
Published: August 2020

AbstractThe time‐dependent operation of methanol, ammonia, and urea production units embedded in a steel mill environment is analyzed with dynamic simulation models. From different process concepts and gas availability scenarios, a set of simulation cases is defined with blast furnace gas as carbon and coke oven gas as hydrogen source. Dynamic simulations indicate that significant CO2 reductions require large amounts of additional H2 from sustainable sources. From the results, global data such as carbon footprint or energy demands and details about process unit operation are obtained and processed.
Biodegradation of catechol by Pseudomonas fluorescens isolated from petroleum‐impacted soil
Authors: Huang Xiaoyan , Shen Siyang , Lin Yen‐Han 
Published: August 2020

AbstractBioremediation strategies have been applied to clean up petroleum hydrocarbon (PHC) impacted sites. Introducing PHC degrading microorganisms (bioaugmentation) and enhancing the in‐situ nutrients availability (biostimulation) are widely used strategies. These strategies can be combined to lead to a better bioremediation performance. In this work, Pseudomonas fluorescens was isolated from a PHC impacted site. Through a 23 factorial design plan, the effect of various combinations of nitrate, sulphate, and phosphate ions on the PHC bioremediation performance by P. fluorescens was investigated using catechol, an essential metabolic intermediate of BTEX degradation, as the sole carbon source. The maximum specific catechol degradation rate was chosen as the response to evaluate the catechol bioremediation performance. The ANOVA results indicated that the presence of nitrate ions alone lowered the maximum specific catechol degradation rate, which can be explained by the accumulation of nitrites and ammonia during the denitrification process by P. fluorescens. It was noted that dosing sulphate ions alone did not affect the bioremediation performance, which indicates P. fluorescens can grow in a sulphur‐limited environment. In contrast, the presence of sulphate and nitrate ions together can lead to a higher specific catechol degradation rate. This may be caused by the presence of sulphate that can suppress the production of nitrites. The importance of phosphate ions on catechol biodegradation was investigated. The absence of phosphate led to incomplete biodegradation. Introducing phosphate ions can accelerate catechol degradation, which can be explained by the secretion of organic acids.
Inequalities in heart failure care in a tax‐financed universal healthcare system: a nationwide population‐based cohort study
Authors: Schjødt Inge , Johnsen Søren P. , Strömberg Anna , Valentin Jan B. , Løgstrup Brian B. 
Published: August 2020

AbstractAimsData on socioeconomic‐related differences in heart failure (HF) care are sparse. Inequality in care may potentially contribute to a poor clinical outcome. We examined socioeconomic‐related differences in quality of HF care among patients with incident HF with reduced ejection fraction (EF) (HFrEF).Methods and resultsWe conducted a nationwide population‐based cohort study among patients with HFrEF (EF ≤40%) registered from January 2008 to October 2015 in the Danish Heart Failure Registry, a nationwide registry of patients with a first‐time primary HF diagnosis. Associations between individual‐level socioeconomic factors (cohabitation status, education, and family income) and the quality of HF care defined by six guideline‐recommended process performance measures [New York Heart Association (NYHA) classification, treatment with angiotensin‐converting‐enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB), beta‐blockers and mineralocorticoid receptor antagonists, exercise training, and patient education] were assessed using multiple imputation and multivariable logistic regression controlling for potential confounders. Among 17 122 HFrEF patients included, 15 290 patients had data on all six process performance measures. Living alone was associated with lower odds of NYHA classification [adjusted OR (aOR) 0.81; 95% confidence interval (CI): 0.72–0.90], prescription of ACEI/ARB (aOR 0.76; 95% CI: 0.68–0.88) and beta‐blockers (aOR 0.84; 95% CI: 0.76–0.93), referral to exercise training (aOR 0.75; 95% CI: 0.69–0.81), and patient education (aOR 0.73; 95% CI: 0.67–0.80). Compared with high‐level education, low‐level education was associated with lower odds of NYHA classification (aOR 0.93; 95% CI: 0.79–1.11), treatment with ACEI/ARB (aOR 0.99; 95% CI: 0.81–1.20) and beta‐blockers (aOR 0.93; 95% CI: 0.79–1.09), referral to exercise training (aOR 0.73; 95% CI: 0.65–0.82), and patient education (aOR 0.86, 95% CI: 0.75–0.98). An income in the lowest tertile was associated with lower odds of NYHA classification (aOR 0.67; 95% CI: 0.58–0.79), prescription of ACEI/ARB (aOR 0.80, 95% CI: 0.67–0.95) and beta‐blockers (aOR 0.88, 95% CI: 0.86–1.01), referral to exercise training (aOR 0.59, 95% CI: 0.53–0.64), and patient education (aOR 0.66; 95% CI: 0.59–0.74) compared with an income in the highest tertile. Overall, no systematic differences were seen when the analyses were stratified by sex and age groups.ConclusionsLiving alone, low‐level education, and income in the lowest tertile were associated with reduced use of recommended processes of HF care among Danish HFrEF patients with a first‐time primary HF diagnosis. Efforts are warranted to ensure guideline‐recommended HF care to all HFrEF patients, irrespective of socioeconomic background.
Evaluation of Acute and Chronic Toxicity of Nickel and Zinc to 2 Sensitive Freshwater Benthic Invertebrates Using Refined Testing Methods
Authors: Wang Ning , Kunz James L. , Cleveland Danielle M. , Steevens Jeffery A. , Hammer Edward J. , Van Genderen Eric , Ryan Adam C. , Schlekat Christian E. 
Published: August 2020

Abstract
The US Environmental Protection Agency (USEPA) is reviewing the protectiveness of the national ambient water quality criteria (WQC) for nickel (Ni) and zinc (Zn) and compiling toxicity databases to update the WQC. An amphipod (Hyalella azteca) and a unionid mussel (Lampsilis siliquoidea) have shown high sensitivity to Ni and Zn in previous studies. However, there remained uncertainties regarding the influence of test duration (48 vs 96 h) and the presence and absence of food in acute exposures with the amphipod, and there were also concerns about poor control of amphipod growth and reproduction and mussel growth in chronic exposures. We conducted acute 48- and 96-h water-only toxicity tests to evaluate the influence of feeding and test durations on the toxicity of dissolved Ni and Zn to the amphipod; we also used recently refined test methods to conduct chronic Ni and Zn toxicity tests to evaluate the sensitivity of the amphipod (6-wk exposure) and the mussel (4- and 12-wk exposures). The 96-h 50% effect concentrations (EC50s) of 916 µg Ni/L and 99 µg Zn/L from acute amphipod tests without feeding decreased from the 48-h EC50s by 62 and 33%, respectively, whereas the 96-h EC50s of 2732 µg Ni/L and 194 µg Zn/L from the tests with feeding decreased from the 48-h EC50s by 10 and 26%, indicating that the presence or absence of food had apparent implications for the 96-h EC50. Our chronic 6-wk EC20s for the amphipod (4.5 µg Ni/L and 35 µg Zn/L) were 50 to 67% lower than the 6-wk EC20s from previous amphipod tests, and our chronic 4-wk EC20s for the mussel (41 µg Ni/L and 66 µg Zn/L) were similar to or up to 42% lower than the 4-wk EC20s from previous mussel tests. The lower EC20s from the present study likely reflect more accurate estimates of inherent sensitivity to Ni and Zn due to the refined test conditions. Finally, increasing the chronic test duration from 4 to 12 wk substantially increased the toxicity of Zn to the mussel, whereas the 4- and 12-wk Ni effect needs to be re-evaluated to understand the large degree of variation in organism responses observed in the present study. Environ Toxicol Chem 2020;39:2256–2268. © 2020 SETAC
Culture from overseas and corporate transparency: Evidence from China
Authors: Hao Ying , Han Danni , Ning Chong , Liao Jianhui 
Published: August 2020

AbstractWe study how cultural norms from overseas affect corporate transparency. Using cultural background information on board directors, we document that corporations with directors with culture from overseas have greater corporate transparency. Specifically, we show that firms with directors with foreign cultural background have more voluntary information disclosure, more analyst coverage, more accurate earnings forecast and less earnings management. Moreover, these firms are more likely to choose Big 4 auditors. We also find that the relationship between culture from overseas and corporate transparency are more strongly positive when the directors have foreign experience from more incorruptible countries or districts. Our findings provide evidence on how directors spread transparency cultural norms rooted in their hearts to firms in developing countries.
Validation of the difficulties with emotion regulation scale in a sample of trauma‐exposed Black women
Authors: Mekawi Yara , Watson‐Singleton Natalie N. , Dixon Hayley D. , Fani Negar , Michopoulos Vasiliki , Powers Abigail 
Published: August 2020

AbstractBackgroundThe Difficulties in Emotion Regulation Scale (DERS) is commonly used to assess dimensions of emotion dysregulation, including emotion nonacceptance, limited strategies, and difficulty with goal‐directed behavior, impulse control, and emotional clarity. Despite considerable work examining the DERS' factor structure, reliability, and validity, there is limited psychometric support for its use with Black women.Objectives(1) Examine the factor structure of the DERS; (2) Compare fit of short‐form versions; and (3) Assess whether scores differ based on diagnoses.MethodSample consisted of Black women (n = 667) recruited in urban, community hospital setting.ResultsThe DERS‐18 correlated traits model without awareness demonstrated the best fit,χ2 (80) = 261.09, root mean square error of approximation = 0.06 [0.05, 0.07], comparative fit index = 0.99, Tucker Lewis Index = 0.98, weighted root mean square residual = 0.89. Additionally, those with current diagnoses of posttraumatic stress disorder (PTSD) or major depressive disorder (MDD) reported higher dysregulation (vs. lifetime/no diagnoses). Further, women with comorbid PTSD/MDD reported greater dysregulation (vs. single disorder/no diagnoses).ConclusionsThis study provides evidence supporting the model fit, reliability, and validity of the DERS‐18 for Black women.
Neonatal presentation of COG6‐CDG with prominent skin phenotype
Authors: Komlosi Katalin , Gläser Selina , Kopp Julia , Hotz Alrun , Alter Svenja , Zimmer Andreas D. , Beger Carmela , Heinzel Stefan , Schmidt Christoph , Fischer Judith 
Published: August 2020

AbstractMany of the genetic childhood disorders leading to death in the perinatal period follow autosomal recessive inheritance and bear specific challenges for genetic counseling and prenatal diagnostics. Often, affected children die before a genetic diagnosis can be established, thereby precluding targeted carrier testing in parents and prenatal or preimplantation genetic diagnosis in further pregnancies. The clinical phenotype of congenital disorders of glycosylation (CDG) is very heterogeneous and ranges from relatively mild symptoms to severe multisystem dysfunction and even a fatal course. A very rare subtype, COG6‐CDG, is caused by deficiency of subunit 6 of the conserved oligomeric Golgi complex and is usually characterized by growth retardation, developmental delay, microcephaly, liver and gastrointestinal disease, joint contractures and episodic fever. It has been proposed that a distinctive feature of COG6‐CDG can be ectodermal signs such as hypohidrosis/hyperthermia, hyperkeratosis and tooth anomalies. In a Greek family, who had lost two children in the neonatal period, with prominent skin features initially resembling restrictive dermopathy, severe arthrogryposis, respiratory insufficiency and a rapid fatal course trio whole‐exome sequencing revealed the homozygous nonsense mutation c.511C>T, p.(Arg171*) in the COG6 gene. Skin manifestations such as dry skin and hyperkeratosis have been reported in only five out of the 21 reported COG6‐CDG cases so far, including two patients with the c.511C>T variant in COG6 but with milder ectodermal symptoms. Our case adds to the phenotypic spectrum of COG6‐CDG with prominent ectodermal manifestations at birth and underlines the importance of considering CDG among the possible causes for congenital syndromic genodermatoses.