bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Note: A Joint Pricing, Supplier Selection, and Inventory Replenishment Model Using the Logit Demand Function*
Authors: Duan Lisha , Ventura José A. 
Published: May 2020

ABSTRACTWe revisit the joint pricing, supplier selection, and inventory replenishment problem for a single item in a two‐stage system examined by Adeinat and Ventura (2015) and use the logit function to model the price‐sensitive demand. This article provides a detailed analysis regarding the shape and properties of the logit demand function. In this context, we propose a two‐stage piecewise‐linear approximation technique to solve the integrated pricing, supplier selection, and inventory replenishment model. Besides, in this research, we provide sufficient justification for the selection of the logit demand function as well as a comparison with other demand functions. A numerical study further suggests the importance of using a precise demand curve to select the set of suppliers, coordinate inventory, and accurately optimize the profit function.
The role of nitric oxide in glutaric acid‐induced convulsive behavior in pup rats
Authors: Brüning César Augusto , Rosa Suzan Gonçalves , Quines Caroline Brandão , Magni Danieli Valnes , Nonemacher Natália Tavares , Bortolatto Cristiani Folharini , Nogueira Cristina Wayne 
Published: May 2020

AbstractGlutaric acidaemia type I (GA‐I) is a cerebral organic disorder characterized by the accumulation of glutaric acid (GA) and seizures. As seizures are precipitated in children with GA‐I and the mechanisms underlying this disorder are not well established, we decided to investigate the role of nitric oxide (NO) in GA‐induced convulsive behaviour in pup rats. Pup male Wistar rats (18‐day‐old) were anesthetized and placed in stereotaxic apparatus for cannula insertion into the striatum for injection of GA. The experiments were performed 3 days after surgery (pup rats 21‐day‐old). An inhibitor of NO synthesis (N‐G‐nitro‐l‐arginine methyl ester—L‐NAME, 40 mg/kg) or saline (vehicle) was administered intraperitoneally 30 min before the intrastriatal injection of GA (1 µl, 1.3 µmol/striatum) or saline. Immediately after the intrastriatal injections, the latency and duration of seizures were recorded for 20 min. The administration of L‐NAME significantly increased the latency to the first seizure episode and reduced the duration of seizures induced by GA in pup rats. The administration of the NO precursor l‐arginine (L‐ARG; 80 mg/kg) prevented the effects of L‐NAME. Besides, GA significantly increased nitrate and nitrite (NOx) levels in the striatum of pup rats and the preadministration of L‐NAME prevented this alteration. L‐ARG blocked the reduction of striatal NOx provoked by L‐NAME. These results are experimental evidence that NO plays a role in the seizures induced by GA in pup rats, being valuable in understanding the physiopathology of neurological signs observed in children with this organic acidaemia and to develop new therapeutic strategies.
How to govern mixed migration in Europe: transnational expert networks and knowledge creation in international organizations
Authors: KORTENDIEK NELE 
Published: May 2020

AbstractMixed migration is an international regime in the making. The migration and refugee crisis put the topic high on the global agenda and multilateral initiatives like the Global Compacts for Migration and Refugees have started to address it. However, it is a contested policy issue and agreement on legally binding instruments is difficult to achieve. While formal global mixed migration governance is thus only emerging, in this article I argue that international organizations shape how mixed migration is governed through informal means. Mixed migration experts in intergovernmental organizations, regional agencies and non‐governmental organizations form networks that cut across organizational levels and boundaries to create practical knowledge and to train fieldworkers. Based on interviews and the analysis of training material, this article shows that they have considerable influence over policy implementation because they control the content of training tools and devise scripts for best practices that guide how mixed migration is governed on the ground.
A randomized controlled study of 6% gabapentin topical formulation for chronic kidney disease‐associated pruritus
Authors: Aquino Terese Monette O. , Luchangco Karla Angela C. , Sanchez Elizabeth V. , Verallo‐Rowell Vermen M. 
Published: May 2020

AbstractBackgroundNovel agents with good safety profiles are needed in the management of chronic kidney disease–associated pruritus (CKD‐AP). This study aims to assess the efficacy and safety of topical gabapentin in the treatment of CKD‐AP.MethodsThe authors conducted a randomized, double‐blind, vehicle‐controlled study. The key inclusion criteria were: (i) patients on hemodialysis for at least 8 weeks, and (ii) a baseline visual analog scale (VAS) pruritus score ≥5. Patients were randomized into two groups. Topical 6% gabapentin was used in the experimental group while plain permeation cream was used for the control group. The primary endpoint was the mean change in pruritus scores using the VAS (MCPS‐VAS) from baseline after 1 and 2 weeks of once daily application.ResultsThirty patients (15 per group) were included in the analysis. Treatment with 6% topical gabapentin resulted in significantly decreased mean pruritus scores at 1 week (mean score 2.7; range 0–5; P < 0.001) and 2 weeks (mean score 1.3, range 0–5; P < 0.001) from baseline (mean score 5.9; range 5–8). The MCPS‐VAS of the two groups were not significantly different (P = 0.8) after 1 week. However, the MCPS‐VAS of the experimental group (mean change −4.6; range 0–7) was significantly greater (P = 0.01) compared to control (mean change −2.6; range −1 to 5) after 2 weeks. There were no drug‐related adverse events reported.ConclusionOur results suggest that short‐term use of topical gabapentin may significantly decrease CKD‐AP severity after 2 weeks with no reported acute adverse events.
Explaining differences in unemployment benefit takeup between labour migrants and Dutch native workers
Authors: Strockmeijer Anita , de Beer Paul , Dagevos Jaco 
Published: May 2020

AbstractThe large increase in Eastern European migrants entering the Dutch labour market has led to concerns about their potential claim on Dutch unemployment benefits. We use a decomposition analysis to investigate differences in uptake of unemployment benefits between migrants and native Dutch employees by analysing register data for all employees in the Netherlands in 2015. The results show that Eastern European migrants, similar to other migrants, receive unemployment benefit more often than native Dutch employees. This difference can be largely ascribed to job characteristics. The inclusion of unemployment risk in the analysis reveals that non‐working migrants are much less likely to receive unemployment benefits than Dutch natives.
The impact of self‐advocacy organizations on the subjective well‐being of people with intellectual disabilities: A systematic review of the literature
Authors: Tilley Elizabeth , Strnadová Iva , Danker Joanne , Walmsley Jan , Loblinzk Julie 
Published: May 2020

AbstractBackgroundA high sense of subjective well‐being has been associated with more prosocial behaviours, better health, work productivity and positive relationships. The aim of this systematic review was to explore what impact self‐advocacy has on the subjective well‐being of people with intellectual disabilities.MethodThe authors reviewed articles focusing on the perspectives of adults with intellectual disabilities engaged with self‐advocacy groups. Searches were performed in PsychINFO, Web of Science, SCOPUS, MEDLINE and CIHNL databases, resulting in 16 articles meeting the inclusion criteria. A framework synthesis approach was used to extract data deductively based on the Dynamic Model of Wellbeing.ResultsWhile self‐advocacy has a positive impact on all domains of the Dynamic Model of Wellbeing, negative impacts associated with participation in a self‐advocacy group were also reported.ConclusionsThe benefits of participating in self‐advocacy groups on the well‐being of individuals with intellectual disabilities outweigh the disadvantages.
The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives
Authors: Quoc Lam Bao , Shrivastava Sushant K. , Shrivastava Anju , Shankar Sharmila , Srivastava Rakesh K. 
Published: May 2020

AbstractThe incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer‐related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, metabolism and microenvironment within the pancreas can also modulate pancreatic carcinogenesis. The risk of PC on a population level may be reduced by modifiable lifestyle risk factors. In this review, the interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of diabetes and PC were discussed.
#Online harms or benefits? An ethnographic analysis of the positives and negatives of peer‐support around self‐harm on social media
Authors: Lavis Anna , Winter Rachel 
Published: May 2020

BackgroundThere is emerging evidence of the potentially detrimental impact of social media on young people’s mental health. Against this background, online self‐harm content has been a recent focus of concern across academia, policy and the media. It has been argued to encourage or even cause acts such as self‐cutting through mechanisms of contagion. However, little is known about why a young person might engage with such content or about its impact on behaviour or well‐being.MethodsOnline ethnographic observation of interactions around self‐harm on Twitter, Reddit and Instagram: collection and analysis of 10,169 original posts and 36,934 comments, both written and pictorial, at two time‐points in 2018 and 2019. Ten in‐depth semi‐structured interviews exploring engagements with self‐harm content on social media.ResultsOur data show that peer support is the central component of online interactions around self‐harm. Young people accessing such content are likely to already be self‐harming; they may turn to social media to understand, and seek help for, their actions and feelings in a context of offline stigma and service support gaps. This paper engages with the mechanisms, complexities and impact of this peer‐support, reflecting on the benefits and dangers to caring for oneself and others through social media.ConclusionsSelf‐harm content is a fraught issue at the centre of current debates around risks and opportunities for child and adolescent mental health in the digital age. Whilst the importance of supporting young people’s online safety is clear, moves to eradicate self‐harm content must be undertaken with caution so as not to cause unintentional harm. Our research highlights a need to think beyond a model of contagion, instead attending to other mechanisms of harm and benefit. In so doing, it challenges prevailing attitudes towards online communication about self‐harm and accepted approaches to managing this.
Research Review: Brain network connectivity and the heterogeneity of depression in adolescence – a precision mental health perspective
Authors: Chahal Rajpreet , Gotlib Ian H. , Guyer Amanda E. 
Published: May 2020

BackgroundAdolescence is a period of high risk for the onset of depression, characterized by variability in symptoms, severity, and course. During adolescence, the neurocircuitry implicated in depression continues to mature, suggesting that it is an important period for intervention. Reflecting the recent emergence of ‘precision mental health’ – a person‐centered approach to identifying, preventing, and treating psychopathology – researchers have begun to document associations between heterogeneity in features of depression and individual differences in brain circuitry, most frequently in resting‐state functional connectivity (RSFC).MethodsIn this review, we present emerging work examining pre‐ and post‐treatment measures of network connectivity in depressed adolescents; these studies reveal potential intervention‐specific neural markers of treatment efficacy. We also review findings from studies examining associations between network connectivity and both types of depressive symptoms and response to treatment in adults, and indicate how this work can be extended to depressed adolescents. Finally, we offer recommendations for research that we believe will advance the science of precision mental health of adolescence.ResultsNascent studies suggest that linking RSFC‐based pathophysiological variation with effects of different types of treatment and changes in mood following specific interventions will strengthen predictions of prognosis and treatment response. Studies with larger sample sizes and direct comparisons of treatments are required to determine whether RSFC patterns are reliable neuromarkers of treatment response for depressed adolescents. Although we are not yet at the point of using RSFC to guide clinical decision‐making, findings from research examining the stability and reliability of RSFC point to a favorable future for network‐based clinical phenotyping.ConclusionsDelineating the correspondence between specific clinical characteristics of depression (e.g., symptoms, severity, and treatment response) and patterns of network‐based connectivity will facilitate the development of more tailored and effective approaches to the assessment, prevention, and treatment of depression in adolescents.
Visualization techniques of the facial arteries
Authors: Mespreuve Marc , Waked Karl , Hendrickx Benoit 
Published: May 2020

AbstractBackgroundAs the face is known for its extreme variation in vascular anatomy and the number of filler‐associated complications due to intra‐arterial injection is increasing, we are in need of a method to visualize anyone’s individual arterial anatomy of the face in a completely harmless way.AimsThe different medical imaging methods and a recently developed MRA protocol are reviewed.MethodsThe literature of the last twenty years—with special attention for the last five years—concerning the different medical imaging modalities of the facial arteries was reviewed.ResultsA harmless visualisation of the facial arteries is currently only possible with US or MRA. US may identify single vessels but never the complete arterial network. A combination of IR “heat enhancement” and a MRA 3D‐TOF sequence might make it feasible to visualize a large number of facial arteries in a risk‐free, radiation‐free, contrast‐free and non‐invasive way.ConclusionCurrently, a new combination of IR “heat enhancement” and a MRA 3D‐TOF sequence might be the only method to visualize a large number of facial arteries.
Clinical evaluation method for blue light (456 nm) protection of skin
Authors: Jo Hong Li , Jung Yuchul , Suh Byung‐Fhy , Cho Eunbyul , Kim Kyungtae , Kim Eunjoo 
Published: May 2020

AbstractBackgroundBlue light from electronic devices enriched with a peak at 456 nm affects circadian rhythm and antioxidant balance of skin, necessitating the study of photoprotection against the 456‐nm blue light.AimsThis study aims to report that blue light (456 nm) can cause skin pigmentation and proposes a new clinical evaluation method for blue light (456 nm) protection based on the skin pigmentation level.Patients/MethodsWe developed a clinical device (ABC deviceTM) that emits blue light (peak = 456 nm). Based on the minimal persistent pigment darkening dose (MPPD) determined from visual evaluation and melanin index measurements, we proposed the “protection grade of blue light (PB)” guideline to assess the protective ability of skin against blue light.ResultsHuman skin irradiated with blue light (456 nm) showed a light dose‐dependent degree of pigmentation. The MPPD on unprotected and protected skin was 135 J/cm2 or 180 J/cm2 and 135‐225 J/cm2, respectively. The ABC device™ and the proposed clinical method were used to test the four blue light blocking assessments of TiO2. Consequently, the inorganic filter with TiO2 effectively blocked the blue light (456 nm). The AP product demonstrated the ability to block blue light by 1.15 times (PB = 1.15), which significantly lowered the melanin index of the skin after irradiation as compared to that of the unprotected skin (P < .001).ConclusionWe propose an objective clinical evaluation method for blue light protection. This study elucidates the properties of blue light blockers for customers suffering from blue light pollution.
Aesthetic dermatology procedures in coronavirus days
Authors: Türsen Ümit , Türsen Belma , Lotti Torello 
Published: May 2020

AbstractBackgroundSevere acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2; COVID‐19), which causes coronavirus disease 2019, is highly contagious and a particularly popular problem in all around the world and also in all departments of every hospital.AimsProtecting the well‐being of the aesthetic dermatologists while providing a sufficient workforce is vital for pandemic planning.Results and ConclusionsIn this article, we will discuss this problem from an aesthetic dermatology aspect and we will review whether these procedures are safe or not.
Terrestrial locomotion in elongate fishes: exploring the roles of morphology and substrate in facilitating locomotion
Authors: Mehta R. S. , Akesson K. , Redmann E. , McCarty‐Glenn M. , Ortega R. , Syed S. , Yap‐Chiongco M. , Jacquemetton C. , Ward A. B. 
Published: May 2020

AbstractHighly elongate body plans have evolved multiple times in the Actinopterygii, and members of many of these groups are known to use lateral undulation on land. Here, we quantified components of the axial skeleton for four phylogenetically disparate actinopterygian fishes and one sarcopterygian to determine whether axial morphology may affect their locomotor kinematics. We tested species in water and on two terrestrial substrates: loose wet pebbles and wet sand. Differences in axial morphology translated to differences in wavelengths, amplitudes, and frequencies at the center of the body and tail while swimming, but overall, we consistently observed a similar shift in kinematic patterns when fish were moving on the two terrestrial treatments. Generally, our kinematic data support our hypothesis that elongate fishes increased their wave frequency and shorten their wavelengths on terrestrial substrates but we also observed lower wave amplitudes contrary to our prediction. As anticipated, animals exhibited a higher distance ratio (DR), our metric of locomotor efficiency, at the head, center of the body, and tail in aquatic trials. DRs were between 25% and 50% higher in water compared to terrestrial treatments. Locomotion was less effective on wet sand substrate compared to loose wet pebble substrate as exhibited by the discrepancy in DRs and wave patterns along the fish. These data suggest that loose wet pebble substrates do indeed provide vertical points for lateral force transmission and that highly elongate fish have an advantage when moving along this substrate. Our species varied greatly in their total vertebral numbers, 93–129, and in their proportion of precaudal (42–102) and caudal vertebral numbers (10–64). Therefore, despite major differences in vertebral proportions, we find that fishes with anguilliform body plans share similar suites of kinematic patterns within aquatic versus terrestrial treatments and that a pebble substrate can better facilitate axial movements.
Sampling interplanetary dust from Antarctic air
Authors: Taylor S. , Lever J. H. , Burgess K. D. , Stroud R. M. , Brownlee D. E. , Nittler L. R. , Bardyn A. , Alexander C. M. O’D. , Farley K. A. , Treffkorn J. , Messenger S. , Wozniakiewicz P. J. 
Published: May 2020

AbstractWe built a collector to filter interplanetary dust particles (IDPs) larger than 5 μm from the clean air at the Amundsen Scott South Pole station. Our sampling strategy used long duration, continuous dry filtering of near‐surface air in place of short duration, high‐speed impact collection on flags flown in the stratosphere. We filtered ~107 m3 of clean Antarctic air through 20 cm diameter, 3 µm filters coupled to a suction blower of modest power consumption (5–6 kW). Our collector ran continuously for 2 years and yielded 41 filters for analyses. Based on stratospheric concentrations, we predicted that each month’s collection would provide 300–900 IDPs for analysis. We identified 19 extraterrestrial (ET) particles on the 66 cm2 of filter examined, which represented ~0.5% of the exposed filter surfaces. The 11 ET particles larger than 5 µm yield about a fifth of the expected flux based on >5 µm stratospheric ET particle flux. Of the 19 ET particles identified, four were chondritic porous IDPs, seven were FeNiS beads, two were FeNi grains, and six were chondritic material with FeNiS components. Most were <10 µm in diameter and none were cluster particles. Additionally, a carbon‐rich candidate particle was found to have a small 15N isotopic enrichment, supporting an ET origin. Many other candidate grains, including chondritic glasses and C‐rich particles with Mg and Si and FeS grains, require further analysis to determine if they are ET. The vast majority of exposed filter surfaces remain to be examined.
Advancing nursing practice for improved health outcomes using the principles of perceptual control theory
Authors: Griffiths Robert , Carey Timothy A. 
Published: May 2020

AbstractThis article describes how an empirically supported theory of human behaviour, perceptual control theory, can be used to advance nursing practice and improve health outcomes for people who are accessing nursing care. Nursing often takes a pragmatic approach to the delivery of care, with an emphasis on doing what appears to work. This focus on pragmatism can sometimes take precedence over any consideration of the underlying theoretical assumptions that inform decisions to take one particular approach over another or the mechanisms through which nursing interventions have their effects. For nursing to develop as a profession, there needs to be an increased focus on the core principles that underpin the delivery of care. In addition to understanding what works, nurses must develop their understanding of how and why particular approaches work or do not work. Understanding the fundamental principles that underpin nurses’ actions will lead to more efficient and effective approaches to the delivery of nursing care. It will also enable nurses to maximize those elements of their practice that are most beneficial for people and minimize other activities that either have little effect or actually lead to worse outcomes. In this article, we will propose that the phenomenon of control is fundamental to human health. Perceptual control theory provides a coherent theoretical framework that enables us to understand the phenomenon of control through a functional model of human behaviour. People are healthy when their neurochemical, physiological, biological, psychological and social states are all controlled satisfactorily. We will explain the implications of understanding health as control throughout the paper. From this perspective, we will argue that the aim of nurses and nursing should be to support people to maintain or recover control over those aspects of their lives that are important and meaningful to them.