bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles
Authors: Qian Shehua , Golubnitschaja Olga , Zhan Xianquan 
Published: November 2019

AbstractA strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between chronic inflammation and tumor has been presented by the relationships between Helicobacter pylori, chronic gastritis, and gastric cancer; between smoking, development of chronic pneumonia, and lung cancer; and between hepatitis virus (mainly hepatitis virus B and C), development of chronic hepatitis, and liver cancer. The prevention of chronic inflammation is a factor that can prevent cancer, so it effectively inhibits or blocks the occurrence, development, and progression of the chronic inflammation process playing important roles in the prevention of cancer. Monitoring of the causes and inflammatory factors in chronic inflammation processes is a useful way to predict cancer and assess the efficiency of cancer prevention. Chronic inflammation-based biomarkers are useful tools to predict and prevent cancer.
Gastrodin Derivatives from Gastrodia elata
Authors: Xu Cheng-Bo , Guo Qing-Lan , Wang Ya-Nan , Lin Sheng , Zhu Cheng-Gen , Shi Jian-Gong 
Published: November 2019

Abstract
Nine new gastrodin derivatives, including seven p-hydroxybenzyl-modified gastrodin ethers (1–7), 6′-O-acetylgastrodin (8), and 4-[α-d-glucopyranosyl-(1 →6)-β-d-glucopyranosyloxy]benzyl alcohol (9), together with seven known derivatives, were isolated from an aqueous extract of Gastrodia elata (“tian ma”) rhizomes. Their structures were determined by spectroscopic and chemical methods as well as single crystal X-ray diffraction. Compounds 1–4, 7, 10, and 11 were also isolated from a reaction mixture by refluxing gastrodin and p-hydroxybenzyl alcohol in H2O. As both gastrodin and p-hydroxybenzyl alcohol exist in the plant, the reaction results provide evidence for the production and increase/decrease of potential effective/toxic components when “tian ma” is decocted solely or together with ingredients in Chinese traditional medicine formulations, though the isolates were inactive in the preliminarily cell-based assays at concentrations of 10 μM. Moreover, using ultra-performance liquid chromatography high-resolution electrospray ionization mass spectrometry (UPLC-HRESIMS), 4, 7, 10, and 11, as well as component variations, were detectable in the freshly prepared extracts of different types of samples, including the freeze-dried fresh G. elata rhizomes.

Graphic Abstract
Formulation of a new finite element based on assumed strains for membrane structures
Authors: Fortas Lahcene , Belounar Lamine , Merzouki Tarek 
Published: November 2019

AbstractIn this paper, a new triangular membrane finite element with in-plane drilling rotation has been developed using the strain-based approach for static and free vibration analyses. The proposed element, having three degrees of freedom at each of the three corner nodes, is based on assumed strain functions satisfying both compatibility and equilibrium equations. Numerical investigations have been conducted using several tests, including static and free vibration problems, and the obtained results are compared with analytical and numerical available solutions. It is found that efficient convergence characteristics and accurate results can be achieved using the developed element.
Dilemma in two game structures for a closed-loop supply chain under the influence of government incentives
Authors: Saha Subrata , Nielsen Izabela Ewa , Majumder Sani 
Published: November 2019

AbstractThe government organizations grant incentives to promote green product consumption, improve green product quality, boost remanufacturing activities, etc. through various policies. The objective of this study is to highlight pros and cons of two incentive policies, namely (1) incentive on manufacturer’s R&D investment and (2) direct incentive to consumer based on greening level of the product on the optimal pricing and investment decisions in improving used product return and greening level decisions in a closed-loop supply chain (CLSC). Optimal decisions are derived under manufacturer and retailer-Stackelberg games, and results are compared to explore characteristics of optimal decisions, consumer surplus, and environmental improvement under two marketing strategies of a manufacturer. It is found that the greening level and used product return rate in a CLSC are always higher under retailer-Stackelberg game. If the manufacturer sets a target for greening level, the CLSC members may receive higher profits if consumer receives incentive because of higher consumer surplus. However, environmental improvement may be lower. If the manufacturer sets a product return goal, then CLSC members may compromise with consumer surplus or environmental improvement for receiving higher profits. In the presence of direct incentive to consumers, CLSC members can trade with product at lower greening level for higher profits. Moreover, investment in improving used product return is always less compared to the investment in improving greening level.
Origin of the hydrate bound gases in the Juhugeng Sag, Muli Basin, Tibetan Plateau
Authors: Liu Shiming , Tan Furong , Huo Ting , Tang Shuheng , Zhao Weixiao , Chao Haide 
Published: November 2019

AbstractThe Juhugeng Sag, located in northwest of the Muli Basin, Tibetan Plateau, has been investigated for coal and petroleum resources during the past several decades. There have been successful recoveries of gas hydrates during recent years from the Middle Jurassic Yaojie Formation that offer insight into the origin of the hydrocarbon gases from the complex sag feature. This study examines the organic geochemical and stable carbon isotopic characteristics of shale and coal samples from the Middle Jurassic Yaojie Formation of the Juhugeng Sag, as well as compares with carbon isotopes, gas amounts and components of hydrate-bound gas. A total of 19 samples from surface mining, including 12 samples of black shale and 7 samples of coal, were analysed using a micro-photometer, a gas chromatograph, Rock–Eval and isotope methods. All the shale samples contained 100% type I kerogen, and the random vitrinite reflectance values vary from 0.65% to 1.32% and achieve thermal pyrolysis phase. Isotope values of methane (δ13C ranging from − 52.6‰ to − 39.5‰ andδD ranging from − 285‰ to − 227‰) in the hydrate bound gases suggest that the methane originates mainly from thermogenic contributions. It is proposed that ethane from the gas hydrate is thermogenic-produced, and this conjecture is supported by the fact that most of the gas hydrate also contains more than 30% of thermogenic C2+hydrocarbons and is similar to structure II hydrate. Carbon isotope data from the gas hydrates show a positive carbon isotope series (δ13C1 < δ13C2 < δ13C3), with ethaneδ13C values being lighter than − 28.5‰, as high consistency with source rocks from the Jurassic period indicate thermal oil-prone gas. A model of the accumulation of gas hydrate is plotted. However, the gaseous sources of gas hydrates may be a subject for more research.
All Binder-Free Electrodes for High-Performance Wearable Aqueous Rechargeable Sodium-Ion Batteries
Authors: He Bing , Man Ping , Zhang Qichong , Fu Huili , Zhou Zhenyu , Li Chaowei , Li Qiulong , Wei Lei , Yao Yagang 
Published: November 2019

AbstractExtensive efforts have recently been devoted to the construction of aqueous rechargeable sodium-ion batteries (ARSIBs) for large-scale energy-storage applications due to their desired properties of abundant sodium resources and inherently safer aqueous electrolytes. However, it is still a significant challenge to develop highly flexible ARSIBs ascribing to the lack of flexible electrode materials. In this work, nanocube-like KNiFe(CN)6 (KNHCF) and rugby ball-like NaTi2(PO4)3 (NTP) are grown on carbon nanotube fibers via simple and mild methods as the flexible binder-free cathode (KNHCF@CNTF) and anode (NTP@CNTF), respectively. Taking advantage of their high conductivity, fast charge transport paths, and large accessible surface area, the as-fabricated binder-free electrodes display admirable electrochemical performance. Inspired by the remarkable flexibility of the binder-free electrodes and the synergy of KNHCF@CNTF and NTP@CNTF, a high-performance quasi-solid-state fiber-shaped ARSIB (FARSIB) is successfully assembled for the first time. Significantly, the as-assembled FARSIB possesses a high capacity of 34.21 mAh cm−3 and impressive energy density of 39.32 mWh cm−3. More encouragingly, our FARSIB delivers superior mechanical flexibility with only 5.7% of initial capacity loss after bending at 90° for over 3000 cycles. Thus, this work opens up an avenue to design ultraflexible ARSIBs based on all binder-free electrodes for powering wearable and portable electronics.
The Landscape Ecology of Rivers: from Patch-Based to Spatial Network Analyses
Authors: Erős Tibor , Lowe Winsor H. 
Published: November 2019

AbstractPurpose of ReviewWe synthesize recent methodological and conceptual advances in the field of riverscape ecology, emphasizing areas of synergy with current research in landscape ecology.Recent FindingsRecent advances in riverscape ecology highlight the need for spatially explicit examinations of how network structure influences ecological pattern and process, instead of the simple linear (upstream-downstream) view. Developments in GIS, remote sensing, and computer technologies already offer powerful tools for the application of patch- and gradient-based models for characterizing abiotic and biotic heterogeneity across a range of spatial and temporal scales. Along with graph-based analyses and spatial statistical stream network models (i.e., geostatistical modelling), these approaches offer improved capabilities for quantifying spatial and temporal heterogeneity and connectivity relationships, thereby allowing for rigorous and high-resolution analyses of pattern, process, and scale relationships.SummarySpatially explicit network approaches are able to quantify and predict biogeochemical, hydromorphological, and ecological patterns and processes more precisely than models based on longitudinal or lateral riverine gradients alone. Currently, local habitat characteristics appear to be more important than spatial effects in determining population and community dynamics, but this conclusion may change with direct quantification of the movement of materials, energy, and organisms along channels and across ecosystem boundaries—a key to improving riverscape ecology. Coupling spatially explicit riverscape models with optimization approaches will improve land protection and water management efforts, and help to resolve the land sharing vs. land sparing debate.
Chip-to-Chip Authentication Method Based on SRAM PUF and Public Key Cryptography
Authors: Karageorgos Ioannis , Isgenc Mehmet M. , Pagliarini Samuel , Pileggi Larry 
Published: November 2019

AbstractIn today’s globalized integrated circuit (IC) ecosystem, untrusted foundries are often procured to build critical systems since they offer state-of-the-art silicon with the best performance available. On the other hand, ICs that originate from trusted fabrication cannot match the same performance level since trusted fabrication is often available on legacy nodes. Split-Chip is a dual-IC approach that leverages the performance of an untrusted IC and combines it with the guaranties of a trusted IC. In this paper, we provide a framework for chip-to-chip authentication that can further improve a Split-Chip system by protecting it from attacks that are unique to Split-Chip. A hardware implementation that utilizes an SRAM-based PUF as an identifier and public key cryptography for handshake is discussed. Circuit characteristics are provided, where the trusted IC is designed in a 28-nm CMOS technology and the untrusted IC is designed in an also commercial 16-nm CMOS technology. Most importantly, our solution does not require a processor for performing any of the handshake or cryptography tasks, thus being not susceptible to software vulnerabilities and exploits.
Online health information–seeking behavior by endocrinology patients
Authors: Kyriacou Angelos , Sherratt Cathy 
Published: November 2019

Abstract
Purpose
Given that the Internet is important for health-related information (HRI) and the fact that online health information (OHI)–seeking behavior has never been studied in endocrinology, we set out to examine how and why the Internet is utilized for HRI, the frequency of such activity, its impact, future information needs, and the effect of language.

Methods
A mainly quantitative, embedded mixed-methods study was performed, employing a questionnaire survey. We included 312 patients (78.4% response rate).

Results
OHI-seeking was reported by 175 patients (56.1%), especially in younger (p = 0.037) and more educated (p = 0.006) patients. OHI-seekers perceived OHI to be high-quality (135, 77.1%) but 104 (59.4%) were unaware of website certification tools. Among OHI-seekers, 63 (36.6%) reported positive behavioral changes after seeking OHI. Only 45 (25.7%) OHI-seekers discussed their gathered information with their endocrinologist. If an interactive e-learning module was available, 194/312 (62.2%) patients expressed willingness to use it, especially those reporting a need for more HRI (p = 0.024). Native speakers were more likely to report that OHI did not meet their information needs (p < 0.001).

Conclusions
OHI-seeking by patients attending the endocrinology outpatients is widely practiced. The availability of OHI in the native language and e-learning modules may enhance the utility of the Internet for health information.
Photocatalytic Degradation of Methylene Blue Over Layered Double Hydroxides Using Various Divalent Metal Ions
Authors: Pan Guoxiang , Xu Minhong , Zhou Kai , Meng Yue , Chen Haifeng , Guo Yuhua , Wu Tao 
Published: November 2019

AbstractTo apply hydrotalcites more effectively to the problem of dye wastewater, the effects of divalent metal ions on the structure and stability of hydrotalcites, especially on their photocatalytic activity, were compared. In the present study, M/Cr hydrotalcites (M3Cr-CO3-LDHs) (in which M = Mg, Co, Ni, Cu, Zn), where the M/Cr molar ratio was 3, were prepared by the co-precipitation method. The structures and properties were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric-differential thermal analysis (TG-DTA), and UV-Visible diffuse reflectance spectroscopy (UV-Vis DRS). The results showed that five kinds of M3Cr-CO3-LDHs were synthesized successfully, and the layered structure of the samples obtained was regular and the crystal phase was single. When methylene blue (MB) solution was exposed to ZnCr-CO3-LDHs, H2O2, and visible light irradiation, more than 90.67% of the methylene blue (MB) was removed after 140 min. The photocatalytic activity of the samples was in the order: Co3Cr-CO3-LDHs > Mg3Cr-CO3-LDHs > Cu3Cr-CO3-LDHs > Zn3Cr-CO3-LDHs > Ni3Cr-CO3-LDHs. The results of a catalytic mechanism study showed that photocatalytic degradation of MB involved a demethylation reaction, with the reactive species containing •O2-, •OH, and h+.
Prevention of Alzheimer's disease by treating mild cognitive impairment with combinations chosen from eight available drugs
Authors: Fessel Jeffrey 
Published: November 2019

AbstractSeveral hundred clinical trials of initially promising drugs have failed to produce meaningful clinical improvement of Alzheimer's disease (AD), which is probably because there are at least 25 biochemical pathways known to be aberrant that underpin the disease, and unless there is a single drug that addresses all or most of them, even promising drugs if given alone are unlikely to succeed. Because so many pathways are potentially at fault, it is quite possible that no treatment might succeed. However, because amnestic mild cognitive impairment (aMCI) often precedes AD and, assuming that those with aMCI who progress to AD commence with insufficient risk factors for AD but accrue them later, then it is likely that fewer pathways need addressing in aMCI than in AD to either prevent progression of aMCI to AD or effect its reversion. Published reports show that eight drugs, that is, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, and silymarin, address many of the pathways underlying MCI and AD. Among those eight drugs, combinations between either two or three of them have combined nonoverlapping actions that benefit enough of the approximately 25 pathways at fault so that their convergent efficacy has the potential to prevent aMCI from progressing to AD. The combinations should be subjected to a clinical trial in persons with aMCI to establish their safety and efficacy.
Reconstruction of sea-surface temperatures in the Canary Islands during Marine Isotope Stage 11
Authors: Clauzel Thibault , Maréchal Chloé , Fourel François , Barral Abel , Amiot Romain , Betancort Juan-Francisco , Lomoschitz Alejandro , Meco Joaquín , Lécuyer Christophe 
Published: November 2019

AbstractThe study of paleoclimates enables us to improve and better constrain climate models in order to forecast future climate variations. Marine Isotope Stage 11 (MIS11), which began around 425,000 yr BP and lasted about 65,000 yr, is a warm isotope stage of paramount importance, because the astronomical configuration was similar to the one characterizing the Holocene. Therefore, this warm isotope stage is the most appropriate analog to present-day climate known to date. This study aims to provide new data on sea-surface temperatures (SSTs) inferred from the carbon and oxygen isotope compositions of skeletal carbonates of marine invertebrates preserved in two marine deposits of the Canary Islands located at Piedra Alta, Lanzarote, and Arucas, Gran Canaria. According to published isotopic fractionation equations the marine deposit from Arucas recorded SSTs of 15.9 ± 2.2°C on average, while the tsunamite from Piedra Alta recorded SSTs of 21.2 ± 1.9°C on average. Absolute dating, mollusc assemblages, and calculated marine temperatures suggest that the Arucas marine deposit corresponds to the beginning of MIS11, while the Piedra Alta tsunamite was formed during MIS11c. These results show that low latitudes also experienced sizable SST changes during interglacial stages.
Slowing life history (K) can account for increasing micro-innovation rates and GDP growth, but not macro-innovation rates, which declined following the end of the Industrial Revolution
Authors: Woodley of Menie Michael A. , Figueredo Aurelio José , Sarraf Matthew A. 
Published: November 2019

AbstractBaumard proposes that life history slowing in populations over time is the principal driver of innovation rates. We show that this is only true of micro-innovation rates, which reflect cognitive and economic specialization as an adaptation to high population density, and not macro-innovation rates, which relate more to a population's level of general intelligence.
England first, America second: The ecological predictors of life history and innovation
Authors: Luoto Severi , Rantala Markus J. , Krams Indrikis 
Published: November 2019

AbstractWe present data from 122 nations showing that Baumard's argument on the ecological predictors of life history strategies and innovation is incomplete. Our analyses indicate that wealth, parasite stress, and cold climate impose orthogonal effects on life histories, innovation, and industrialization. Baumard also overlooks the historical exploitation of other nations which significantly enlarged the “pooled energy budget” available to England.
Effects of waveguides on a free-electron laser with two electron beams
Authors: Nam Soon-Kwon , Park Yunseong 
Published: November 2019

AbstractThe effects of the phase variation, the evolution of the electron beam, the evolution of the radiation intensity, and the higher-order modes due to waveguides on a free-electron laser (FEL) oscillator have been analyzed by using two electron beams of different energies based on the proposed FEL facility which is to be operated in the far-infrared and infrared regions. The three-dimensional (3D) effects on a FEL oscillator due to waveguides and higher-order modes were studied using an extended 3D FEL code with two electron beams that we have developed. The effects of the variation on the amplitude of radiation on the electron beam's emittance and energy spreads were also calculated in the case of waveguide for multi-particle and multi-pass numbers by using a new 3D code. The phase variation, the variation in the beam envelope, the evolution of the amplitude, and power were calculated for the fundamental mode. The results were compared with those of the higher-order modes of the wiggler for various TE and TM modes for determining the FEL's performance which is required for high-quality electron beams.
Localization and obstacle avoidance in soccer competition of humanoid robot by gait and vision system
Authors: Chiang Shu-Yin , Lu Jia-Huei 
Published: November 2019

AbstractIn this study, we designed a localization and obstacle avoidance system for humanoid robots in the Federation of International Robot-soccer Association (FIRA) HuroCup united soccer competition event. The localization is implemented by using grid points, gait, and steps to determine the positions of each robot. To increase the localization accuracy and eliminate the accumulated distance errors resulting from step counting, the localization is augmented with image pattern matching using a system model. The system also enables the robot to determine the ball’s position on the field using a color model of the ball. Moreover, to avoid obstacles, the robots calculate the obstacle distance using data extracted from real-time images and determine a suitable direction for movement. With the integration of this accurate self-localization algorithm, ball identification scheme, and obstacle avoidance system, the robot team is capable of accomplishing the necessary tasks for a FIRA soccer game.
Cube complexes and abelian subgroups of automorphism groups of RAAGs
Authors: MILLARD BENJAMIN , VOGTMANN KAREN 
Published: November 2019

AbstractWe construct free abelian subgroups of the group U(AΓ) of untwisted outer automorphisms of a right-angled Artin group, thus giving lower bounds on the virtual cohomological dimension. The group U(AΓ) was studied in [5] by constructing a contractible cube complex on which it acts properly and cocompactly, giving an upper bound for the virtual cohomological dimension. The ranks of our free abelian subgroups are equal to the dimensions of principal cubes in this complex. These are often of maximal dimension, so that the upper and lower bounds agree. In many cases when the principal cubes are not of maximal dimension we show there is an invariant contractible subcomplex of strictly lower dimension.