bluuebunny/crossref_metadata_2025_split huggingface dataset:
A candidate secular variation model for IGRF-13 based on MHD dynamo simulation and 4DEnVar data assimilation
Authors: Minami Takuto , Nakano Shin’ya , Lesur Vincent , Takahashi Futoshi , Matsushima Masaki , Shimizu Hisayoshi , Nakashima Ryosuke , Taniguchi Hinami , Toh Hiroaki 
Published: September 2020

AbstractWe have submitted a secular variation (SV) candidate model for the thirteenth generation of International Geomagnetic Reference Field model (IGRF-13) using a data assimilation scheme and a magnetohydrodynamic (MHD) dynamo simulation code. This is the first contribution to the IGRF community from research groups in Japan. A geomagnetic field model derived from magnetic observatory hourly means, and CHAMP and Swarm-A satellite data, has been used as input data to the assimilation scheme. We adopt an ensemble-based assimilation scheme, called four-dimensional ensemble-based variational method (4DEnVar), which linearizes outputs of MHD dynamo simulation with respect to the deviation from a dynamo state vector at an initial condition. The data vector for the assimilation consists of the poloidal scalar potential of the geomagnetic field at the core surface and flow velocity field slightly below the core surface. Dimensionless time of numerical geodynamo is adjusted to the actual time by comparison of secular variation time scales. For SV prediction, we first generate an ensemble of dynamo simulation results from a free dynamo run. We then assimilate the ensemble to the data with a 10-year assimilation window through iterations, and finally forecast future SV by the weighted sum of the future extension parts of the ensemble members. Hindcast of the method for the assimilation window from 2004.50 to 2014.25 confirms that the linear approximation holds for 10-year assimilation window with our iterative ensemble renewal method. We demonstrate that the forecast performance of our data assimilation and forecast scheme is comparable with that of IGRF-12 by comparing data misfits 4.5 years after the release epoch. For estimation of our IGRF-13SV candidate model, we set assimilation window from 2009.50 to 2019.50. We generate our final SV candidate model by linear fitting for the weighted sum of the ensemble MHD dynamo simulation members from 2019.50 to 2025.00. We derive errors of our SV candidate model by one standard deviation of SV histograms based on all the ensemble members.
The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung
Authors: Leligdowicz Aleksandra , Ross James T. , Nesseler Nicolas , Matthay Michael A. 
Published: September 2020

Abstract
Background
The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to experimental conditions. However, there is a lack of studies evaluating biomarker kinetics during perfusion and after exposure to stimuli. In this study, we analyzed the ex vivo-perfused lung response to three key perturbations: exposure to the perfusion circuit, exogenous fresh whole blood, and bacteria.

Results
Ninety-nine lungs rejected for transplantation underwent ex vivo perfusion. One hour after reaching experimental conditions, fresh whole blood was added to the perfusate (n = 55). Two hours after reaching target temperature, Streptococcus pneumoniae was added to the perfusate (n = 42) or to the airspaces (n = 17). Perfusate and airspace samples were collected at baseline (once lungs were equilibrated for 1 h, but before blood or bacteria were added) and 4 h later. Interleukin (IL)-6, IL-8, angiopoietin (Ang)-2, and soluble tumor necrosis factor receptor (sTNFR)-1 were quantified. Baseline perfusate and airspace biomarker levels varied significantly, and this was not related to pre-procurement PaO2:FiO2 ratio, cold ischemia time, and baseline alveolar fluid clearance (AFC). After 4 h of ex vivo perfusion, the lung demonstrated a sustained production of proinflammatory mediators. The change in biomarker levels was not influenced by baseline donor lung characteristics (cold ischemia time, baseline AFC) nor was it associated with measures of experimental epithelial (final AFC) or endothelial (percent weight gain) injury. In the presence of exogenous blood, the rise in biomarkers was attenuated. Lungs exposed to intravenous (IV) bacteria relative to control lungs demonstrated a significantly higher rise in perfusate IL-6.

Conclusions
The ex vivo-perfused lung has a marked endogenous capacity to produce inflammatory mediators over the course of short-term perfusion that is not significantly influenced by donor lung characteristics or the presence of exogenous blood, and only minimally affected by the introduction of systemic bacteremia. The lack of association between biomarker change and donor lung cold ischemia time, final alveolar fluid clearance, and experimental percent weight gain suggests that the maintained ability of the human lung to produce biomarkers is not merely a marker of lung epithelial or endothelial injury, but may support the function of the lung as an immune cell reservoir.
New findings on submerged patch reefs and reefal carbonate rocks at water depths of 70–100 m on the insular shelf off Miyako-jima, southern Ryukyus, Japan
Authors: Inoue Takahiko , Arai Kohsaku 
Published: September 2020

AbstractSub-bottom profiling (SBP) surveys and bathymetric mapping conducted off the shore of Miyako-jima, which belongs to the southern Ryukyus in the Ryukyu Island Arc, have revealed the presence of mound-shaped structures 3–8 m high and 50–120 m wide at depths of 70–100 m. The SBP surveys showed that the mounds possess strong distinct, convex upward reflector shapes at the top, which we interpret as submerged reefs and reefal sediments. Additionally, modern stratified sediment layers that cover these mound-shaped structures indicate that those reefs began forming and advancing shoreward in a back-stepping fashion as a result of sea-level rise. An analysis of the mound distribution shown by SBP and multibeam echo sounding (MBES) surveys suggest that they might have been formed during the lowstand stage of sea-level change, which includes the Last Glacial Period, because the distribution of these mounds is limited to water depths of 70 to 100 m, deeper than where present-day reefs grow. The SBP images hint that such high-resolution seismic profiles, accompanied by detailed bathymetric mapping off the reefal area, have the potential to provide effective indicators of not only coral reef paleoenvironment development, but also the tectonic setting of this offshore area.
Mental health status in veterans residing in rural versus non-rural areas: results from the veterans’ health study
Authors: Boscarino Joseph J. , Figley Charles R. , Adams Richard E. , Urosevich Thomas G. , Kirchner H. Lester , Boscarino Joseph A. 
Published: September 2020

Abstract
Background
The majority of Veterans Affair (VA) hospitals are in urban areas. We examined whether veterans residing in rural areas have lower mental health service use and poorer mental health status.

Methods
Veterans with at least 1 warzone deployment in central and northeastern Pennsylvania were randomly selected for an interview. Mental health status, including PTSD, major depression, alcohol abuse and mental health global severity, were assessed using structured interviews. Psychiatric service use was based on self-reported utilization in the past 12 months. Results were compared between veterans residing in rural and non-rural areas. Data were also analyzed using multivariate logistic regression to minimize the influence by confounding factors.

Results
A total of 1730 subjects (55% of the eligible veterans) responded to the survey and 1692 of them had complete geocode information. Those that did not have this information (n = 38), were excluded from some analyses. Veterans residing in rural areas were older, more often of the white race, married, and experienced fewer stressful events. In comparison to those residing in non-rural areas, veterans residing in rural areas had lower global mental health severity scores; they also had fewer mental health visits. In multivariate logistic regression, rural residence was associated with lower service use, but not with PTSD, major depression, alcohol abuse, and global mental health severity score after adjusting confounding factors (e.g., age, gender, marital status and education).

Conclusions
Rural residence is associated with lower mental health service use, but not with poor mental health in veterans with former warzone deployment, suggesting rural residence is possibly protective.
Reducing Injuries in Soccer (Football): an Umbrella Review of Best Evidence Across the Epidemiological Framework for Prevention
Authors: Owoeye Oluwatoyosi B. A. , VanderWey Mitchell J. , Pike Ian 
Published: September 2020

AbstractSoccer is the most popular sport in the world. Expectedly, the incidence of soccer-related injuries is high and these injuries exert a significant burden on individuals and families, including health and financial burdens, and on the socioeconomic and healthcare systems. Using established injury prevention frameworks, we present a concise synthesis of the most recent scientific evidence regarding injury rates, characteristics, mechanisms, risk and protective factors, interventions for prevention, and implementation of interventions in soccer. In this umbrella review, we elucidate the most recent available evidence gleaned primarily from systematic reviews and meta-analyses. Further, we express the exigent need to move current soccer injury prevention research evidence into action for improved player outcomes and widespread impact through increased attention to dissemination and implementation research. Additionally, we highlight the importance of an enabling context and effective implementation strategies for the successful integration of evidence-based injury prevention programs into real-world soccer settings. This narrative umbrella review provides guidance to inform future research, practice, and policy towards reducing injuries among soccer players.
The effect of structured versus unstructured collaborative pre-writing task on writing skills of the Iranian EFL students
Authors: Beiki Maryam , Gharagozloo Neda , Raissi Reza 
Published: September 2020

AbstractWriting is considered a very complicated task for many EFL students and Iranian EFL learners have many problems in this regard. Present study through a mixed method design, attempted to investigate the effect of Structured Collaborative (SC) pre-writing task versus Unstructured Collaborative (USC) pre-writing task on the writing ability of Iranian EFL students. Among a population of 300 freshmen learners of English language translation of Islamic Azad University, 169 students were selected based on criterion sampling. The criteria for selecting the sample were English language proficiency of the learners, age of the participants and major of their study. On the other hand, 30 teachers were selected based on convenience sampling for the interview part of the study. Then the students were assigned to Unstructured Collaborative (USC), and Structured Collaborative (SC) pre-writing groups. These two clusters were considered as experimental group and as control group. The study was implemented over a period of 16 weeks and involved pre and post-tests. Results of the quantitative data analysis shows that students’ writing proficiency in both groups were improved. However, the outcomes of the study reveals that the (USC) group outperformed the (SC) group. The qualitative data analysis through classroom observation and teachers interview reveals that teachers of (IAU) practiced the collaborative tasks at the three stages of writing in their classes and they also favored and applied the five components of Cooperative Learning (CL). In this study, the researchers took the initiative to make a distinction between structured and unstructured collaborative pre-writing tasks. Consequently, the results of the current study are of benefit for several groups of people, namely language practitioners, university students and educational administrators.
Trends in fertility and fertility preferences in sub-Saharan Africa: the roles of education and family planning programs
Authors: Bongaarts John 
Published: September 2020

AbstractA common explanation for the high fertility prevailing in sub-Saharan Africa (SSA) is a widespread desire for large families. This situation poses a challenge to population policy-makers in the continent. If the desired family size is high, then presumably family planning programs can only have a limited effect on fertility because these programs aim to assist women in achieving their reproductive goals. But this conclusion is based on the assumption that family planning programs do not affect the desired family size, which is questionable and is investigated here. This study examines the determinants of trends wanted and unwanted fertility in SSA using fixed-effects regressions of country-level data. The dependent variables include the total fertility rate, and its wanted and unwanted components. Explanatory variables include a family planning program score and four socioeconomic variables (women’s educational attainment, child mortality, GNI per capita, and percent urban). Data come from 103 DHS surveys in 25 countries in SSA with at least two DHS surveys between 1989 and 2019. Women’s education and family planning programs are found to be the dominant determinants of fertility decline and their effects operate by reducing both wanted and unwanted fertility. The effects of education are not surprising but the finding that family planning programs can reduce wanted fertility implies that their impact can be larger than conventional wisdom suggests. Indeed, in a few poor countries, the implementation of high-quality programs has been associated with substantial declines in wanted fertility (e.g., Ethiopia, Malawi, Rwanda). The mechanism through which this effect operates is unclear but likely involves media programs that diffuse knowledge about the benefits of smaller families.
Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis
Authors: Lee Yi , Clark Evan W. , Milan Marina S.D. , Champagne Christine , Michael Kesi S. , Awad Mark M. , Barbie David A. , Cheng Michael L. , Kehl Kenneth L. , Marcoux J. Paul , Rabin Michael S. , Rotow Julia K. , Sands Jacob M. , Jänne Pasi A. , Oxnard Geoffrey R. 
Published: September 2020

PURPOSE Genomic analysis of plasma cell-free DNA has become a widespread tool for advanced non–small-cell lung cancer care. Whereas accuracy has been reported on widely, its usefulness is also tied tightly to its turnaround time (TAT), which is not well studied. METHODS We studied the TAT of commercial plasma next-generation sequencing (NGS; Guardant360) for 533 results from 461 patients at our center between August 2016 and October 2019. The study received institutional review board approval as a quality improvement study; therefore, the results of the test and clinical setting were not analyzed. RESULTS TAT from blood draw to result (median of 9 days) was slightly longer than the TAT from laboratory receipt to result, a median of 7 days. Testing volume at our center increased three-fold over the time of the study. During this period, clinical TAT decreased from an initial median of 12 days to a median of 8 days in 2018, but more recently the median increased slightly to 9 days. During the most recent 12 months, 231 (95%) of 247 cases resulted within 14 days from blood draw, with delayed results usually because of billing, whereas 44 cases (18%) resulted within 7 days of blood draw. Studying 92 cases drawn in the most recent 3-month period, the median time of result receipt was 4:01 pm Eastern Time/1:01 pm Pacific Time; 39 results (43%) were returned after 5:00 pm Eastern Time. CONCLUSION In a large single-institution experience, we find that plasma NGS results can routinely be expected within 2 weeks, but uncommonly result within 1 week, supporting the need for new strategies to incorporate plasma NGS into the initial genotyping of advanced non–small-cell lung cancer.
Measurement of modular values and connection to the annihilation operator
Authors: Li Xiaogang , Gao Jiancun 
Published: September 2020

Abstract
Modular value of an observable of a pre- and postselected quantum system is a concept similar to weak value, but in contrast to describing only weak coupling, it can describe the coupling of any strength but only for qubit meters, so it may be used more widely in some scenarios. Besides, modular value has been proved to have advantages on measuring weak values of nonlocal joint observables and nonlocal entanglement states. In this paper, we extend the work of J. S. Lundeen and K. J. Reschb on connection between the measured values of multiparticle observables of a pre- and postselected quantum system and annihilation operator by modular value and give their relation. Based on the above, we propose a new method different from tomography to measure modular values, and we find that our annihilation operator measurement (AOM) method can significantly reduce the number of measurements from O(4
n
) to O(2
n
) compared with the original tomography method.
Weight Loss and Serum Lipids in Overweight and Obese Adults: A Systematic Review and Meta-Analysis
Authors: Hasan Bashar , Nayfeh Tarek , Alzuabi Muayad , Wang Zhen , Kuchkuntla Aravind Reddy , Prokop Larry J , Newman Connie B , Murad Mohammad Hassan , Rajjo Tamim I 
Published: September 2020

Abstract

Background
Excess adipose tissue is associated with an abnormal lipid profile that may improve with weight reduction. In this meta-analysis, we aimed to estimate the magnitude of change in lipid parameters associated with weight loss in adults who are overweight or obese.

Methods
We searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus from 2013 to September, 2018. We included randomized controlled trials (RCTs) that evaluated interventions to treat adult obesity (lifestyle, pharmacologic and surgical) with follow-up of 6 months or more.

Results
We included 73 RCTs with moderate-to-low risk of bias, enrolling 32 496 patients (mean age, 48.1 years; weight, 101.6 kg; and body mass index [BMI], 36.3 kg/m2). Lifestyle interventions (diet, exercise, or both), pharmacotherapy, and bariatric surgery were associated with reduced triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) concentrations and increased high-density lipoprotein cholesterol (HDL-C) at 6 and 12 months. The following data are for changes in lipid parameters after 12 months of the intervention with 95% CI. Following lifestyle interventions, per 1 kg of weight lost, TGs were reduced by –4.0 mg/dL (95% CI, –5.24 to –2.77 mg/dL), LDL-C was reduced by –1.28 mg/dL (95% CI, –2.19 to –0.37 mg/dL), and HDL-C increased by 0.46 mg/dL (95% CI, 0.20 to 0.71 mg/dL). Following pharmacologic interventions, per 1 kg of weight lost, TGs were reduced by –1.25 mg/dL (95% CI, –2.94 to 0.43 mg/dL), LDL-C was reduced by –1.67 mg/dL (95% CI, –2.28 to –1.06 mg/dL), and HDL-C increased by 0.37 mg/dL (95% CI, 0.23 to 0.52 mg/dL). Following bariatric surgery, per 1 kg of weight lost, TGs were reduced by –2.47 mg/dL (95% CI, –3.14 to –1.80 mg/dL), LDL-C was reduced by –0.33 mg/dL (95% CI, –0.77 to 0.10 mg/dL), and HDL-C increased by 0.42 mg/dL (95% CI, 0.37 to 0.47 mg/dL). Low-carbohydrate diets resulted in reductions in TGs and increases in HDL-C, whereas low-fat diets resulted in reductions in TGs and LDL-C and increases in HDL-C. Results were consistent across malabsorptive and restrictive surgery.

Conclusions
Weight loss in adults is associated with statistically significant changes in serum lipids. The reported magnitude of improvement can help in setting expectations, inform shared decision making, and facilitate counseling.
Lingering Legacies: Public Attitudes about Medicaid Beneficiaries and Work Requirements
Authors: Haeder Simon F. , Sylvester Steven M. , Callaghan Timothy 
Published: September 2020

AbstractContext: This article provides a detailed picture of the mindset of Americans about Medicaid work requirements and the important roles that perception of deservingness and racial bias play in public attitudes.Methods: The authors conducted a large original survey to investigate public attitudes toward work requirements. They analyzed the predictors of overall support for work requirements, correlates of who should be exempt from them, and attitudes toward work supports that make compliance with work requirements easier.Findings: The authors found that public opinion is split relatively evenly when it comes to Medicaid work requirements in the abstract. When Americans are confronted with the complexities of the issue, important nuances emerge. The authors also found consistent evidence that support for work requirements is higher among conservatives, those who see Medicaid as a short-term program, and racially resentful non-Hispanic whites. They show that groups that have historically been framed as deserving see high levels of support for their exemption (e.g., the disabled and senior citizens). Finally, the authors found that Americans are supportive of policies that provide individuals with help when transitioning into the workforce.Conclusions: Americans' views of Medicaid and the populations it serves are complex and continue to be influenced by perceptions of deservingness and race.
Prostate cancer measurements on serial MRI during active surveillance: it’s time to be PRECISE
Authors: Giganti Francesco , Stavrinides Vasilis , Stabile Armando , Osinibi Elizabeth , Orczyk Clement , Radtke Jan Philipp , Freeman Alex , Haider Aiman , Punwani Shonit , Allen Clare , Emberton Mark , Kirkham Alex , Moore Caroline M 
Published: September 2020

Objective: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1–5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. Methods: We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on T2 weighted imaging (T2WI) according to all definitions. A PRECISE score was assessed for each patient. Results: The ellipsoid formula exhibited the highest correlation with planimetry at baseline (ρ = 0.97) and follow-up (ρ = 0.98) imaging, compared to the biaxial measurement and single maximum diameter. There was a significant difference (p < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2–3) and progression (PRECISE 4–5) for planimetry (39.64%) and for the ellipsoid formula (46.78%). Conclusion: The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed. Advances in knowledge: The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on T2WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.