bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of an Academic Electronic Health Record With an Interprofessional Simulation for Advanced Practice Nursing Students
Authors: King Tara Spalla , Schubert Carolyn , Pittman Oralea , Rohrig Lisa , McClerking Carolyn , Barthelmas Tiffin 
Published: February 2020

Abstract
Simulation with interprofessional teams provides case management opportunities for advanced practice RN students they may not encounter in preceptorships. We designed standardized patient simulations to improve health care safety and outcomes; an academic electronic health record was used in some simulations. We report quality improvement findings from 74 APRN students who completed a survey with open-ended questions. We found that simulation in interprofessional teams positively impacted role immersion, confidence, problem-solving skills, and teamwork. Use of the academic electronic health record added realism. The findings are being incorporated as part of continuous quality improvement in the teaching-learning process.
Adverse Childhood Experiences Among Gynecology Patients With Chronic Pelvic Pain
Authors: Krantz Tessa E. , Andrews Nicholas , Petersen Timothy R. , Dunivan Gena C. , Montoya Maria , Swanson Naomi , Wenzl Cynthia K. , Zambrano Julissa R. , Komesu Yuko M. 
Published: February 2020

(Abstracted from Obstet Gynecol 2019;134:1087–1095)
Chronic pelvic pain (CPP)—defined as noncyclic pain present for 6 months or more—is associated with disability, impaired function, depression, and symptoms of posttraumatic stress disorder. Although its underlying pathophysiology is unclear, there appears to be associated psychosocial components.
Planned Early Delivery or Expectant Management for Late Preterm Pre-eclampsia (PHOENIX): A Randomized Controlled Trial
Authors: Chappell Lucy C. , Brocklehurst Peter , Green Marcus E. , Hunter Rachael , Hardy Pollyanna , Juszczak Edmund , Linsell Louise , Chiocchia Virginia , Greenland Melanie , Placzek Anna , Townend John , Marlow Neil , Sandall Jane , Shennan Andrew 
Published: February 2020

(Abstracted from Lancet 2019;394:1181–1190)
Standard management of preeclampsia involves maternal and fetal assessment and careful consideration of timely delivery that strikes a balance between maternal and perinatal morbidity. In women with preeclampsia after 37 weeks of gestation, most national guidelines recommend urgent delivery.
Estimating Yields of Prenatal Carrier Screening and Implications for Design of Expanded Carrier Screening Panels
Authors: Guo Michael H. , Gregg Anthony R. 
Published: February 2020

(Abstracted from Genet Med 2019;21:1940–1947)
Prenatal genetic carrier screening once had a limited focus on a small number of genetic variants for a handful of conditions in high-risk populations. Today, screening occurs across multiple variants in many ancestry groups.
Pain-related Self-efficacy Among People With Back Pain
Authors: Vergeld Vera , Utesch Till 
Published: February 2020

Background:Before an intervention can be implemented to improve pain-related self-efficacy, assessment is required. The aim of the present study was to provide a systematic review on which self-efficacy scales are being used among patients with back pain and to evaluate their psychometric properties.Methods:A systematic search was executed in January 2019 and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 checklist served as a guide for conducting the study. Electronic databases included Cinahl, Medline, PubMed, PsycINFO, PSYNDEX, and SportDiscus. Publications in English or German language that focused on the adult patient population with back pain and which provided validation or reliability measures on pain-related self-efficacy were included.Results:A total of 3512 records were identified resulting in 671 documents after duplicates were removed. A total of 233 studies were screened full-text, and a total of 47 studies addressing 19 different measures of pain-related self-efficacy were included in the quality analysis. The most commonly used instruments were the Pain Self-Efficacy Questionnaire and the Chronic Pain Self-Efficacy Scale. All studies reported internal consistency, but many studies lacked other aspects of reliability and validity.Conclusions:Further research should focus on assessing validity and interpretability of these questionnaires, especially in pain-related target groups. Researchers should select questionnaires that are most appropriate for their study aims and the back pain population and contribute to further validation of these scales to best predict future behavior and develop intervention programs. This systematic review aids selection of pain-related assessment tools in back pain both in research and practice.
Significance of Asymmetry of Groin and Thigh Skin Creases in Developmental Dysplasia of the Hip Revisited: Results of a Comparative Study
Authors: Ömeroğlu Hakan , Tatlici Erdem , Köse Nusret 
Published: February 2020

Background:
No high level of scientific evidence exists about the use of asymmetry of skin creases (ASC) on the groin and thigh regions in diagnosing developmental dysplasia of the hip. The aim of this comparative study was to revisit whether or not ASC was a significant clinical finding in developmental dysplasia of the hip.

Methods:
This was retrospective analysis of a prospectively collected data. Control group was composed of 1000 consecutive healthy infants (mean age, 46.7 d) whose both hips were considered Graf type I (normal). Study group (SG) was composed of 246 consecutive patients (mean age, 96.5 d) whose treatments by abduction bracing were initiated due to unilateral or bilateral Graf type IIa(−) and worse hips.

Results:
SG included 178 patients with bilateral or unilateral dysplastic hips [Graf type IIa(−), IIb, IIc] and 68 patients with at least 1 decentered hip (Graf type D, III, IV). ASC was seen in 63 of 101 patients (63%) having positive clinical finding(s). The rates of both ASC alone (P<0.001; odds ratio, 3.46) and ASC total (ASC with and without additional findings) (P<0.0001; odds ratio, 7.48) were significantly higher in SG than in control group. ASC was the only clinical finding in 31 patients and 24 of these 31 patients (77%) had unilateral or bilateral dysplastic hips. Sensitivity and specificity of ASC alone were 12.60% and 96.00%, respectively. ASC was accompanied by other clinical findings (mostly Galeazzi sign and limitation of abduction) in 32 patients and 23 of these 32 patients (72%) had at least 1 decentered hip. Sensitivity and specificity of ASC total were 25.61% and 95.60%, respectively.

Conclusions:
ASC is a significant finding, as there is considerable increased risk of having dysplastic or decentered hips in infants having such a finding alone or associated with other findings. ASC alone is more commonly seen in patients with dysplastic hip(s) whereas ASC is mostly accompanied with other clinical finding(s) in patients with decentered hip(s). This study shows that, ASC can be introduced as a risk factor in selected newborn hip screening programs.

Level of Evidence:
Level II—diagnostic study.
Neck-Related Headache in Patients With Cervical Disc Disease After Surgery and Physiotherapy
Authors: Svensson Jard , Hermansen Anna , Wibault Johanna , Löfgren Håkan , Dedering Åsa , Öberg Birgitta , Zsigmond Peter , Peolsson Anneli 
Published: February 2020

Study Design.
A prospective randomized multicenter trial.

Objective.
To investigate the effects of surgery with either structured postoperative physiotherapy or standard postoperative approach on neck-related headache in patients with cervical radiculopathy. Secondary, to investigate associations between change in neck-related headache and change in neck muscle endurance, neck mobility, or neck pain.

Summary of Background Data.
The effect of physiotherapy on individuals with neck-related headache after surgery for cervical radiculopathy due to magnetic resonance imaging–verified disc disease is unknown.

Methods.
One hundred six patients with neck-related headache and participating in a randomized controlled trial evaluating the additional effects of physiotherapy after surgery for cervical radiculopathy were included. Patients were randomized preoperatively to structured postoperative physiotherapy (n = 51) or the standard postoperative approach (n = 55). Outcome measures were headache intensity and neck pain intensity, neck muscle endurance, and neck mobility. Measures were obtained preoperatively and at 6 weeks, 3 months, 6 months, and 1 year postoperatively.

Results.
Headache intensity significantly changed from baseline to 1 year postoperatively (P < 0.001) in both groups. Post-hoc tests showed a significant difference between baseline and 6 weeks (P ≤ 0.05). No significant differences were found between groups (P > 0.05) or between-group differences in changes over time (P > 0.05). The change in current headache intensity over time was associated with a change in current neck pain intensity over time (P = 0.003, β = 0.40).

Conclusion.
There was a significant improvement in headache intensity 1 year postoperatively in patients with cervical radiculopathy and neck-related headache, but there were no differences between groups over time. Change in current headache intensity was only associated with a change in current neck pain intensity.

Level of Evidence: 2
Clinical Performance and Concurrent Validity of the Adult Spinal Deformity Surgical Decision-making Score
Authors: Fujishiro Takashi , Boissière Louis , Cawley Derek Thomas , Larrieu Daniel , Gille Olivier , Vital Jean-Marc , Pellisé Ferran , Pérez-Grueso Francisco Javier Sanchez , Kleinstück Frank , Acaroglu Emre , Alanay Ahmet , Obeid Ibrahim 
Published: February 2020

Study Design.
Multicenter, retrospective study.

Objective.
The aim of this study was to examine the performance and concurrent validity of the adult spinal deformity surgical decision-making (ASD-SDM) score compared to decision-making factors in the ASD population.

Summary of Background Data.
The ASD-SDM score, which has been recently proposed, is a scoring system to guide the selection of treatment modality for the ASD population. To secure the justification for its clinical use, it is necessary to verify its clinical performance and concurrent validity.

Methods.
A multicenter prospective ASD database was retrospectively reviewed. The data were analyzed separately in younger (≤40 years) and older (≥41 years) age groups. The discriminating capacity of the ASD-SDM score in cases who selected surgical and nonsurgical management was compared using area under the receiver operator characteristic curves (AUROC). Concurrent validity was examined using Spearman correlation coefficients, comparing factors that are reported to be associated with the decision-making process for ASD, including baseline symptomatology, health-related quality of life measures, and the severity of radiographic spinal deformity.

Results.
There were 338 patients (mean age: 26.6 years; 80.8% female; 129 surgical and 209 nonsurgical) in the younger age group and 750 patients (mean age: 63.5 years; 84.3% female; 410 surgical and 340 nonsurgical) in the older age group. In both younger and older patients, the ASD-SDM score showed a significantly higher performance for discriminating the surgical and nonsurgical cases (AUROC: 0.767, standard error [SE]: 0.026, P < 0.001, 95% confidence interval [CI]: 0.712–0.813; AUROC: 0.781, SE: 0.017, P < 0.001, 95% CI: 0.747–0.812, respectively) compared to the decision-making factors analyzed. In addition, the ASD-SDM showed significant correlations with multiple decision-making factors.

Conclusion.
The ASD-SDM score alone can effectively grade the indication for surgical management whilst considering multiple decision-making factors.

Level of Evidence: 3
Transpedicular Vertebrectomy With Circumferential Spinal Cord Decompression and Reconstruction for Thoracic Spine Metastasis
Authors: Rustagi Tarush , Mashaly Hazem , Ganguly Ranjit , Akhter Asad , Mendel Ehud 
Published: February 2020

Study Design.
Retrospective case series.

Objective.
To study the feasibility, outcomes, and complications of transpedicular vertebrectomy (TPV), and reconstruction for metastatic lesions to the thoracic spine.

Summary of Background Data.
Metastatic lesions to the thoracic spine may need surgical treatment requiring anterior–posterior decompression/stabilization. Anterior reconstruction may be performed using poly methyl meth acrylate (PMMA) cement or cages. Use of cement has been reported to be associated with complications.

Methods.
From 2008 to 2016, consecutive cases (single surgeon) undergoing TPV for thoracic spine metastasis (T2–12) were included. Demographic, surgical, and clinical data were collected through chart review. MRI, CT, positron emission tomography images were used to identify extent of disease, epidural spinal cord compression (ESCC), and degree of vertebral body collapse. Hall–Wellner confidence band was used for the survival curve.

Results.
Ninety six patients were studies with a median age 60 years. Most patients 56 (58%) presented with mechanical pain. 29% cases had lung metastasis. Single level TPV was performed in 73 patients (76%). Anterior reconstruction included PMMA in 78 patients (81.25%), and titanium cage in 18 patients (18.25%). Frankel grade improvement was seen in 16 cases (P = 0.013). ESCC improved by a median of 5.9 mm (P < 0.001). Kyphosis reduced by median of 7.5° (P < 0.001). VAS improved by median of seven (P < 0.001). Total 59 deaths were observed. The median survival time was estimated to be 6 months (95% CI: 5, 10). Surgical outcome and complication rates are similar between the two construct types. Correction of kyphosis was seen to be slightly better with the use of PMMA. Overall 29.16% cases developed complications (11.4% major). Two cases developed neurological deficit following epidural hematoma requiring surgery. One case had instrumentation failure from cement migration, needing revision.

Conclusion.
The result of our study shows significantly improved clinical and radiological outcomes for TPV for thoracic metastatic lesions. We also discuss some important steps for use of PMMA to avoid complications.

Level of Evidence: 4
Robotic-assisted Spine Surgery: A Review of its Development, Outcomes, and Economics on Practice
Authors: Kia Cameron , Esmende Sean 
Published: February 2020

Purpose:
Improper pedicle screw placement can lead to increased complications and the need for revision surgery. The purpose of this article is to review the history of robotic assistance in spine surgery, along with the current data on its clinical outcomes, potential advantages, and economics on practice.

Methods:
Review of the literature.

Results:
A review of the current literature demonstrated that intrapedicular accuracy has shown to be either superior or equivalent to a free-hand technique. Radiation exposure with robotic assistance is generally similar to free-hand, with a trend toward a lesser exposure following increased experience. Operative times, outcomes, and complication rates have been variable between prospective and retrospective studies, with mostly equivalent results when compared with free-hand screw placement.

Conclusions:
Higher-level studies (level I and II) have demonstrated similar clinical outcomes and pedicle screw accuracy when compared with the free-hand technique. As with most new technology, a learning curve is apparent, with the potential for a decrease in radiation exposure and economic benefit over time.
Expression of Stromal Cell–Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis
Authors: Kwon Min-Young , Ghanta Sailaja , Ng Julie , Tsoyi Konstantin , Lederer James A. , Bronson Roderick T. , El-Chemaly Souheil , Chung Su Wol , Liu Xiaoli , Perrella Mark A. 
Published: February 2020

Objectives:
Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell–derived factor-1 regulates mobilization of neutrophils from the bone marrow. We are investigating the importance of stromal cell-derived factor-1 in mesenchymal stromal cells and its role in promoting neutrophil function after the onset of cecal ligation and puncture–induced sepsis. Stromal cell–derived factor-1 expression was silenced in mesenchymal stromal cells, compared with the control scrambled construct mesenchymal stromal cells.

Design:
Animal study and cell culture.

Setting:
Laboratory investigation.

Subjects:
BALB/c mice.

Interventions:
Polymicrobial sepsis was induced by cecal ligation and puncture. shSCR mesenchymal stromal cells and shSDF-1 mesenchymal stromal cells were delivered by tail vein injections to septic mice. The mice were assessed for survival, bacterial clearance, and the inflammatory response during sepsis in each of the groups. Mesenchymal stromal cells were also assessed for their ability to promote bacterial phagocytosis by neutrophils.

Measurements and Main Results:
Injection of shSCR mesenchymal stromal cells after the onset of sepsis led to an increase in mouse survival (70%) at 7 days, whereas survival of mice receiving shSDF-1 mesenchymal stromal cells was significantly diminished (33%). The loss of survival benefit in mice receiving shSDF-1 mesenchymal stromal cells was associated with less efficient bacterial clearance compared with shSCR mesenchymal stromal cells. Although shSCR mesenchymal stromal cells, or their conditioned medium, were able to increase neutrophil phagocytosis of bacteria, this effect was significantly blunted with shSDF-1 mesenchymal stromal cells. Assessment of peritoneal inflammation revealed that neutrophils were significantly increased and more immature in septic mice receiving shSDF-1 mesenchymal stromal cells. This response was associated with hypocellularity and increased neutrophil death in the bone marrow of mice receiving shSDF-1 mesenchymal stromal cells.

Conclusions:
Expression of stromal cell-derived factor-1 in mesenchymal stromal cells enhances neutrophil function with increased phagocytosis, more efficient clearance of bacteria, and bone marrow protection from depletion of cellular reserves during sepsis.
Locoregional Therapy Protocols With and Without Radioembolization for Hepatocellular Carcinoma as Bridge to Liver Transplantation
Authors: Zori Andreas G. , Ismael Media N. , Limaye Alpna R. , Firpi Roberto , Morelli Giuseppe , Soldevila-Pico Consuelo , Suman Amitabh , Vogel Jeffrey D. , Lazarowicz Michael , Geller Brian S. , Toskich Beau , Gonzalo David H. , Johnson Mark W. , Cabrera Roniel 
Published: February 2020

Objective:
The objective of this study was to compare posttransplant outcomes in patients undergoing bridging locoregional therapy (LRT) with Y-90 transarterial radioembolization (TARE) based protocol compared with transarterial chemoembolization based protocol for hepatocellular carcinoma (HCC) prior liver transplantation (LT).

Materials and Methods:
Patients listed for LT with HCC within the Milan criteria at our center who had bridging LRT were treated according to transarterial chemoembolization (TACE) based protocol from May 2012 to April 2014 and a TARE based protocol from October 2014 to December 2017. Early posttransplant survival and tumor recurrence were compared between the groups. Tumor response to LRT, microvascular invasion (mVI), and the rate of delisting was also evaluated.

Results:
One hundred three patients who were listed for LT with HCC within the Milan criteria received LRT. LT was performed in 65 patients, 28 treated with TARE protocol and 37 on TACE protocol. There were no statistical differences in baseline pretransplant characteristics and tumor recurrence. There was a trend toward improved 3-year survival in the TARE group (92.9% vs. 75.7%; P=0.052). The mVI was seen in 1/28 (3.6%) explants in the TARE group compared with 10/37 (27%) in the TACE group (P=0.013). The TARE group also required fewer LRT treatments (1.46 vs. 2.43; P=0.001) despite no difference in time on the transplant list.

Conclusions:
Despite requiring fewer LRT treatments, there was significantly less mVI in the explants of patients treated with TARE protocol LRT as a bridge to LT as well as a trend toward improved 3-year survival. Therefore, TARE may be associated with improved tumor control and reduced post-LT recurrence.
Granulomatous Skin Diseases in a Tertiary Care Portuguese Hospital: A 10-Year Retrospective Study
Authors: Queirós Catarina Soares , Uva Luís , Soares de Almeida Luís , Filipe Paulo 
Published: February 2020

Abstract:
Granulomatous skin diseases comprise an extensive group of pathologies whose diagnosis usually requires a histopathological examination. At this level, various types of granulomas can be distinguished, namely tuberculoid, sarcoid, necrobiotic, suppurative, xanthogranuloma, and foreign-body granulomas. This study aimed to determine the frequency and pattern of different granulomatous skin lesions in the Dermatopathology Department of Hospital de Santa Maria (Lisboa, Portugal). A retrospective study of all skin biopsies with granulomatous lesions received during a period of 10 years (2008–2017) was performed. Clinical and histopathological characteristics of the selected cases were analyzed, and the lesions were categorized according to histological type of granuloma and etiology. Foreign-body granulomas secondary to ruptured cyst, folliculitis, or suture material were excluded. From a total of 48,253 cutaneous biopsies performed in this period, 461 (1%) granulomatous lesions were included in our study. In the analysis according to type of granuloma, necrobiotic granulomas were the most frequent (N = 111; 27.0%), followed by sarcoidal (N = 72; 17.5%), tuberculoid (N = 51; 12.4%), suppurative (N = 45; 10.9%), foreign body (N = 40; 9.7%), and xanthogranulomas (N = 26; 6.3%). The remaining 20% corresponded to granulomas of other types. During these 10 years, the most frequent etiology was granuloma annulare (N = 98; 88.3%), followed by sarcoidosis (N = 47; 65.3%). Histopathology is a fundamental tool in the diagnosis of granulomatous skin diseases, allowing for the categorization of various types of granulomas and often guiding further investigation of these patients. The geographical area has an influence on the types of granulomas observed, as evidenced by comparing this study with others previously published.