bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ifosfamide (IFO) and doxorubicin (DOX) dose-intensities seem related to overall survival in adult soft-tissue sarcoma (STS) patients
Authors: Almeida G. F. , Castro G. , Snitcovsky I. M. , Bassani A. C. , Diz M. E. , Federico M. H. 
Published: March 2020

9581 Background: IFO/DOX dose intensities (DI) seem to impact on the outcome of STS. We explored retrospectively the relationship between DI and overall survival (OS) in STS. Methods: From Jan/00 to Jun/05, 70 untreated STS pts received IFO/DOX, 32 as neo/adjuvant and 38 in the palliative setting at our outpatient unit. Filgrastin was not mandatory. Median age 47 y (17–74 y), 44 male; mean tumor size 13.6 cm in the neo/adjuvant and 16.5 cm in the palliative group (p=0.202, t-test). Most frequent histologies: leiomyo (16 pts), synovial (13), malignant fibrous histiocytoma (8) and liposarcoma (8). 28 pts had lower/ 9 upper limb tumors, 9 retroperitoneal, 9 trunk, 6 mediastinal, 5 visceral and 4 head and neck. Kaplan-Meier survival curves were considered from diagnosis and compared by log-rank test. Results: For the 70 pts, the mean DI for IFO and DOX were 2.5±0.9 mg/m2/wk and 18.8±6.0 mg/m2/wk, respectively. There was no difference between neo/adjuvant and palliative IFO/DOX DI (p=0.314/p=0.247, respectively). With 19-mo median f-up, the median OS (mOS) was 43 mo in the neo/adjuvant group with an advantage for pts submitted to conservative surgeries (46.5 mo vs. 16.8 mo; HR 0.185, 95%CI 0.003–0.399, p=0.007) as well as in those diagnosed with tumors with less than 3 mitoses/10 HPF (48.3 mo vs. 18.8 mo; HR 0.272, 95%CI 0.058–0.871, p=0.031). No differences in mOS related to tumor size, margin status or primary sites were found. According to IFO DI, the mOS were 46.5 mo, not reached (NR), 14.5 mo and 43 mo for pts in the 1st and subsequent DI quartiles (chi-square test for trend, p=0.004). In the median f-up of 9.8 mo, pts in the palliative setting presented mOS 21.8 mo, superior in the lower grade subgroup (NR vs. 11.1 mo; HR 0.130, 95%CI 0.076–0.746, p=0.014) and in the STS not from extremities (40.9 mo vs. 10.8 mo; HR 2.152, 95%CI 0.959–5.137, p=0.063). According to IFO DI quartiles, we also found a direct correlation between mOS (11.3 mo, 19 mo, 45.1 mo, and NR) and DI (p=0.052), and similar trend was shown for DOX DI, with 11.3 mo, 10.3 mo, NR, and 40.9 mo mOS for the 1st, 2nd, 3rd and 4th quartiles (p=0.018). Conclusions: In these STS adult pts, we have found a relationship between IFO and DOX DI and OS. Further evaluations of more intensive chemotherapy schedules are warranted. No significant financial relationships to disclose.
A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)
Authors: Hudes G. , Carducci M. , Tomczak P. , Dutcher J. , Figlin R. , Kapoor A. , Staroslawska E. , O’Toole T. , Kong S. , Moore L. 
Published: March 2020

LBA4 Background: Temsirolimus (TEMSR, CCI-779) is a specific inhibitor of mTOR, a signaling protein that regulates cell growth and angiogenesis. In a single-agent, phase 2 study, TEMSR administration to heavily pretreated patients (pts, n = 111) with adv RCC resulted in a median overall survival (OS) of 15.0 mos (Atkins et al, J Clin Oncol 2004). Retrospectively, 49 pts were categorized in a poor-risk group (Motzer et al, J Clin Oncol 2002). The TEMSR-treated pts in this group had a 1.7-fold longer median OS than the first-line, IFN-treated, poor-risk group reported by Motzer et al. In a phase 1 study, the maximum tolerated dose of the combination of TEMSR + IFN in adv RCC pts was TEMSR 15 mg intravenously (IV) once/wk + IFN 6 million units (MU) subcutaneously (SC) 3 times weekly (TIW) (Smith et al, Proc ASCO 2004). Thus, this phase 3 study in first-line, poor-risk adv RCC pts was initiated in July 2003. Methods: Pts with adv RCC and no prior systemic therapy were enrolled in this open-label study if they had ≥3 of 6 risk factors (the 5 Motzer criteria and >1 metastatic disease site). Pts were randomized (1:1:1) to arm 1, IFN up to 18 MU SC TIW; arm 2, TEMSR 25 mg IV once/wk; or arm 3, TEMSR 15 mg IV once/wk + IFN 6 MU SC TIW. The primary study endpoint was OS; the study was powered to compare the TEMSR arms with the IFN arm. Results: We report 20 Mar 2006 preliminary data from an interim analysis performed by the IDMC. Of the 626 pts enrolled, 442 deaths occurred. Patients treated with TEMSR had a statistically longer survival than those treated with IFN (Table). OS of patients treated with IFN and TEMSR + IFN were not statistically different. The 3 most frequently occurring adverse events ≥gr 3 were asthenia (arm 1: arm 2: arm 3, 27%: 12%: 30% pts), anemia (24%: 21%: 39% pts), and dyspnea (8%: 9%: 11% pts). Conclusions: Single-agent TEMSR significantly increases the OS of first-line, poor-risk adv RCC pts compared with IFN, with an acceptable safety profile. [Table: see text] [Table: see text]
The study of tamoxifen and raloxifene (STAR): Initial findings from the NSABP P-2 breast cancer prevention study
Authors: Wickerham D. L. , Costantino J. P. , Vogel V. , Cronin W. , Cecchini R. , Atkins J. , Bevers T. , Fehrenbacher L. , McCaskill-Stevens W. , Wolmark N. 
Published: March 2020

LBA5 Background: The STAR trial was designed to compare raloxifene to tamoxifen in terms of relative effect on invasive breast cancer risk and on other beneficial and detrimental outcomes associated with the use of tamoxifen. Methods: The trial opened on 7-1-1999, and accrual was completed November 4, 2004, with 19,747 women enrolled. To be eligible, a woman had to be postmenopausal with a 5-year predicted breast cancer risk of 1.66% as determined by the modified Gail model. Women were randomized and treated in a double-blinded fashion to receive 5 yr of therapy with either 20 mg per day of tamoxifen or 60 mg per day of raloxifene. The protocol-defined monitoring plan called for a final analysis and release of findings when 327 invasive breast cancer cases had been diagnosed in the total population. The mean age of the population at the time of entry into this trial was 58 yr, and the mean 5-yr risk of breast cancer was 4.04%. 93.5% of the women were white; 51.5% had a hysterectomy before entry into the study; 9.2% had a history of LCIS; 71.1% had at least one first-degree relative with a history of breast cancer. The average time on the study is 47 months. Results: There was no difference between the treatment groups in terms of effect on invasive breast cancer: 163 cases in women assigned to tamoxifen and 167 in women assigned to raloxifene (RR = 1.02, 95% CI = 0.82–1.27). The risk of invasive uterine malignancies was 40% less in the raloxifene group (36 in women assigned tamoxifen and 23 in women assigned raloxifene [RR = 0.62, 95% CI = 0.35–1.08]). The risk of non invasive breast cancer was less in the tamoxifen group (57 cases in those assigned to tamoxifen and 81 in those assigned to raloxifene [RR = 1.41, 95% CI = 1.00–2.02]). There were no significant differences between the treatment groups for any of the other invasive cancer sites or for cardiac events, osteoporotic fractures, or deaths. There were fewer thromboembolic events in women taking raloxifene than in those taking tamoxifen. Conclusions: Raloxifene is an effective alternative to tamoxifen for reducing the incidence of invasive breast cancer in postmenopausal women at increased risk of developing the disease and is associated with fewer endometrial cancers, deep vein thromboses, and pulmonary emboli. [Table: see text]
Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)
Authors: Dharmaraj Poonam , Gorvin Caroline M , Soni Astha , Nelhans Nick D , Olesen Mie K , Boon Hannah , Cranston Treena , Thakker Rajesh V , Hannan Fadil M 
Published: March 2020

Abstract

Context
Familial hypocalciuric hypercalcemia type 1 (FHH1) is caused by loss-of-function mutations of the calcium-sensing receptor (CaSR) and is considered a benign condition associated with mild-to-moderate hypercalcemia. However, the children of parents with FHH1 can develop a variety of disorders of calcium homeostasis in infancy.

Objective
The objective of this work is to characterize the range of calcitropic phenotypes in the children of a mother with FHH1.

Methods
A 3-generation FHH kindred was assessed by clinical, biochemical, and mutational analysis following informed consent.

Results
The FHH kindred comprised a hypercalcemic man and his daughter who had hypercalcemia and hypocalciuria, and her 4 children, 2 of whom had asymptomatic hypercalcemia, 1 was normocalcemic, and 1 suffered from transient neonatal hypocalcemia and seizures. The hypocalcemic infant had a serum calcium of 1.57 mmol/L (6.28 mg/dL); normal, 2.0 to 2.8 mmol/L (8.0-11.2 mg/dL) and parathyroid hormone of 2.2 pmol/L; normal 1.0 to 9.3 pmol/L, and required treatment with intravenous calcium gluconate infusions. A novel heterozygous p.Ser448Pro CaSR variant was identified in the hypercalcemic individuals, but not the children with hypocalcemia or normocalcemia. Three-dimensional modeling predicted the p.Ser448Pro variant to disrupt a hydrogen bond interaction within the CaSR extracellular domain. The variant Pro448 CaSR, when expressed in HEK293 cells, significantly impaired CaSR-mediated intracellular calcium mobilization and mitogen-activated protein kinase responses following stimulation with extracellular calcium, thereby demonstrating it to represent a loss-of-function mutation.

Conclusions
Thus, children of a mother with FHH1 can develop hypercalcemia or transient neonatal hypocalcemia, depending on the underlying inherited CaSR mutation, and require investigations for serum calcium and CaSR mutations in early childhood.
Poji: a Fiji-based tool for analysis of podosomes and associated proteins
Authors: Herzog Robert , van den Dries Koen , Cervero Pasquale , Linder Stefan 
Published: March 2020

ABSTRACT
Podosomes are actin-based adhesion and invasion structures in a variety of cell types, with podosome-forming cells displaying up to several hundreds of these structures. Podosome number, distribution and composition can be affected by experimental treatments or during regular turnover, necessitating a tool that is able to detect even subtle differences in podosomal properties. Here, we present a Fiji-based macro code termed ‘Poji’ (‘podosome analysis by Fiji’), which serves as an easy-to-use tool to characterize a variety of cellular and podosomal parameters, including area, fluorescence intensity, relative enrichment of associated proteins and radial podosome intensity profiles. This tool should be useful to gain more detailed insight into the regulation, architecture and functions of podosomes. Moreover, we show that Poji is easily adaptable for the analysis of invadopodia and associated extracellular matrix degradation, and likely also of other micron-size punctate structures. This article describes the workflow of the Poji macro, presents several examples of its applications, and also points out limitations, as well as respective solutions, and adaptable features to streamline the analysis.
This article has an associated First Person interview with the first author of the paper.
Physical Activity across Retirement Transition by Occupation and Mode of Commute
Authors: PULAKKA ANNA , LESKINEN TUIJA , SUORSA KRISTIN , PENTTI JAANA , HALONEN JAANA I. , VAHTERA JUSSI , STENHOLM SARI 
Published: March 2020

ABSTRACT

Purpose
Retirement induces changes in the composition of daily physical activity. Our aim was to examine changes in accelerometer-measured physical activity around transition to statutory retirement among men and women by occupational category and by preretirement modes of commuting.

Methods
We included 562 workers (mean [SD] age, 63.3 [1.1] yr; 85% women) from the Finnish Retirement and Aging study. The participants wore an accelerometer on their nondominant wrist for 1 wk before and 1 wk after retirement, with 1 yr between the measurements. We compared mean daily activity counts before and after retirement between manual and nonmanual occupations by gender and by preretirement commuting mode using linear models with generalized estimating equations.

Results
Before retirement, women were more active than men (2550 (95% confidence interval, 2500–2590) vs 2060 (1970–2140) mean daily activity counts), with the most active group being women in manual occupations. After retirement, physical activity decreased by 3.9% among women and increased, albeit nonsignificantly, by 3.1% in men. The decrease was most pronounced among women in manual and increase among men in nonmanual occupations. After retirement, women remained more active than men (2450 (95% confidence interval 2390–2500) vs 2120 (2010–2230) counts). Active commuting, especially cycling, before retirement was associated with higher physical activity both before and after retirement, and these people also maintained their total activity lever better than did those who commuted by public transportation.

Conclusions
Although women in manual occupations decreased and men in nonmanual occupations increased their activity after retirement, women were more active than men both before and after retirement. Those who engaged in active commuting before retirement maintained their activity level also after retirement.
OS 30 ANOS DA CONSTITUIÇÃO: O PAPEL DO DIREITO E DA JURISDIÇÃO CONSTITUCIONAL
Authors: Streck Lenio Luiz 
Published: March 2020

Passados trinta anos da promulgação da sua Constituição, o Brasil se depara com uma grave crise institucional. Neste momento marcante, procuro refletir sobre o Direito (e sua teoria) em nosso país, desde a redemocratização, especialmente sobre o papel que se atribui à jurisdição constitucional e que ela efetivamente desempenha. Reafirmo o papel transformador do constitucionalismo — tanto mais necessário em países com graves problemas estruturais, como o nosso — argumentando que isso não deve ser confundido com ativismo judicial. Na sequência, discuto parâmetros para a jurisdição constitucional e a construção de uma adequada teoria da Constituição. Por fim, volto da teoria à prática, analisando criticamente algumas dificuldades na efetivação do constitucionalismo contemporâneo no Brasil.
Condiciones sociodemográficas y perfil de salud de los adultos mayores indígenas del departamento de Nariño
Authors: Paredes A. Yenny V. , Yarce P. Eunice , Aguirre A. Daniel C. 
Published: March 2020

Introducción: en América Latina, la etnicidad es un determinante crítico de pobreza, desigualdad y exclusión social; además, puede constituir una situación doble de vulnerabilidad, pues los grupos poblacionales minoritarios requieren atención diferencial. El presente estudio determina los factores sociodemográficos y el perfil de salud de un grupo de adultos mayores indígenas. Materiales y métodos: estudio analítico de tipo descriptivo transversal, con una muestra por conveniencia de 518 adultos mayores ambulatorios indígenas de la exprovincia de Obando, Nariño, Colombia. Mediante una encuesta personal, se recogieron datos sociodemográficos y de antecedentes médicos. La valoración nutricional se realizó con el Mini Nutritional Assessment; la evaluación cognitiva, con el Mini-Mental State Examination; los síntomas depresivos, con la Escala de Depresión Geriátrica de Yesavage; y la capacidad funcional, con el índice de Barthel y la escala de Lawton y Brody. Finalmente, con respecto al análisis estadístico, se empleó el enfoque del análisis de clases latentes, con el objetivo de identificar subgrupos o clases, de acuerdo con los patrones de comorbilidad. Resultados: en cuanto a los datos sociodemográficos, el 44.6 % es de género femenino, el 40.2 % es analfabeta, el 63.5 % está casado, el 91.7 % reside en áreas rurales, y el 53.43 % no posee ingresos. En cuanto a los antecedentes médicos, el 47.7% tiene artritis, seguido por el 23%, que tiene cataratas. El 26 % presenta riesgo nutricional; el 65 %, sintomatología depresiva; el 54 %, deterioro cognitivo; y el 35%, dependencia funcional. El análisis de clases latentes mostró predominio de comorbilidad en un 55 %. Conclusión: en la población de adultos mayores indígenas prevalecen condiciones sociodemográficas y de salud precarias que tienen mayor incidencia que en otros grupos etáreos.
A Structural Estimation Approach to Study Agent Attrition
Authors: Emadi Seyed Morteza , Staats Bradley R. 
Published: March 2020

Worker attrition is a costly and operationally disruptive challenge throughout the world. Although large bodies of research have documented drivers of attrition and the operational consequences of attrition, managers still lack an integrated approach to understanding attrition and making decisions to address it on a forward-going basis. To fill this need, we build a structural model that both captures the firm’s decision to terminate a worker’s employment (involuntary attrition) and uses an optimal stopping problem process to model a worker’s decision to leave the firm (voluntary attrition). We then estimate the parameters of the model and conduct counterfactual analyses on the population of 1,118 agents serving one client over 3 years for an Indian business process management company. Our model reveals a number of interesting findings. We find that supervisors have a strong impact on whether employees stay because they reshape the way that agents make their decisions. We also find that the impact of supervisors on agent attrition is more significant than the impact of salary. For example, increasing salary by 20% decreases the total attrition level by 5%. However, if agents were managed by the best supervisors, among those that manage similar agents, the attrition rate decreases by 10%. Altogether, our paper contributes to the burgeoning literature on people operations and managerial practice. This paper was accepted by Serguei Netessine, operations management.
Exploring the experiences of student midwives completing the newborn infant physical examination: part 2
Authors: Meegan Samantha , Martin Toni 
Published: March 2020

Background This is the second part of a series of two papers which explores the use of interpretative phenomenological analysis (IPA) within midwifery education in order to examine students' perspectives of the newborn infant physical examination (NIPE). Part one, featured in the British Journal of Midwifery volume 28, no 2, explains the background to the development of the study and explores the use of IPA within an emerging aspect of midwifery education. Part two of the series will present the research findings and implications for practice. Objectives This study aims to explore the experiences of student midwives completing the theory and practice aspects of the NIPE within a pre-registration midwifery programme. Design A qualitative design was utilised to analyse data collected by semi-structured interviews. Setting A large university in the West Midlands geographical area. Participants Five student midwives were purposively selected to participate in the study. Methods This study was conducted using IPA. Findings Three superordinate themes were generated: learning by doing, mentorship and transition to qualification. The findings demonstrate the significance of student midwives being exposed to the practical aspect of the NIPE during their training. Conclusions The study findings indicate that standardisation is required within preparation to undertake the NIPE within clinical practice. Higher educational institutes must also provide greater support with regards to the mentorship of student midwife NIPE practitioners. Further research should examine the maintenance of the NIPE role within newly qualified midwives.
100  MHz frequency comb for low-intensity multi-photon studies: intra-cavity velocity-map imaging of xenon
Authors: Nauta J. , Oelmann J.-H. , Ackermann A. , Knauer P. , Pappenberger R. , Borodin A. , Muhammad I. S. , Ledwa H. , Pfeifer T. , Crespo López-Urrutia J. R. 
Published: March 2020

We raise the power from a commercial 10 W frequency comb inside an enhancement cavity and perform multi-photon ionization of gas-phase atoms at 100 MHz for the first time, to the best of our knowledge. An intra-cavity velocity-map-imaging setup collects electron-energy spectra of xenon at rates several orders of magnitude higher than those of conventional laser systems. Consequently, we can use much lower intensities

∼

10

12

W

/

c
m

2

without increasing acquisition times above just a few seconds. The high rate and coherence of the stabilized femtosecond pulses are known to be transferred to the actively stabilized cavity and will allow studying purely perturbative multi-photon effects, paving the road towards a new field of precision tests in nonlinear physics.
Estudio transversal de medición de la composición corporal en pacientes con cáncer mediante antropometría y técnicas de imagen médica
Authors: Muresan Bianca Tabita , Sánchez Juan Carlos , Artero Ana , Montoro Alegría , Hernández Machancoses Ana , Ruiz Berjaga Yesica , Ríos Ríos Jaime , Soriano del Castillo José Miguel , Sebastià Fabregat Natividad , Prieto Colodrero Nieves , López - Torrecilla José 
Published: March 2020

Introducción: Analizar la composición corporal tanto mediante técnicas antropométricas y parámetros bioquímicos clásicos, como mediante técnicas modernas utilizando tomografía computarizada (TC), en pacientes oncológicos antes de iniciar el tratamiento con radioterapia.Metodología: Se analizaron de forma retrospectiva 22 pacientes con diversos tumores del aparato digestivo, que fueron sometidos al TC de planificación antes de iniciar el tratamiento con radioterapia, y que disponían de un corte axial en la tercera vértebra lumbar. Para analizar la composición corporal, se determinaron tanto parámetros antropométricos y bioquímicos clásicos, como la determinación de la masa muscular mediante Unidades Hounsfield (UH).Resultados: En cuanto a las características antropométricas clásicas, el peso medio fue 65,19 (±12,72) Kg, IMC 23,74 (± 5,03) kg/m2, %pp 15,84 (±10,87) %, PT 9,73 (± 5,08) mm y CMB 22,81 (± 2,95) cm. En cuanto a los parámetros bioquímicos, la hipoalbuminemia estuvo presente en el 63,45% de los casos. Por otro lado, la medición de composición corporal mediante técnicas modernas, determinó un promedio de circunferencia de cintura de 99,06 (±13,38) cm, MM de 119,41 (±35,54) cm2, y la media del IME fue de 71,50 (±20.57) cm2/m2; estando por debajo de la normalidad en el 13,64% de los pacientes.Conclusiones: Las nuevas técnicas por imagen basadas en cortes TC, pueden incluirse en la rutina diaria del paciente oncológico como información adicional a los parámetros antropométricos y bioquímicos más clásicos, por ser una técnica sencilla de realizar, con bajo coste, reproducible y muy fiable en cuanto a determinación de composición corporal.