bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus
Authors: Rani Lata , Grewal Ajmer Singh , Sharma Neelam , Singh Sukhbir 
Published: October 2020

Background:
The global incidence of type 2 diabetes mellitus (T2DM) has enthused the
development of new antidiabetic targets with low toxicity and long-term stability. In this respect, free
fatty acid receptor 1 (FFAR1), which is also recognized as a G protein-coupled receptor 40 (GPR40),
is a novel target for the treatment of T2DM. FFAR1/GPR40 has a high level of expression in β-cells
of the pancreas, and the requirement of glucose for stimulating insulin release results in immense
stimulation to utilise this target in the medication of T2DM.

Methods:
The data used for this review is based on the search of several scienctific databases as well
as various patent databases. The main search terms used were free fatty acid receptor 1, FFAR1,
FFAR1 agonists, diabetes mellitus, G protein-coupled receptor 40 (GPR40), GPR40 agonists, GPR40
ligands, type 2 diabetes mellitus and T2DM.

Results:
The present review article gives a brief overview of FFAR1, its role in T2DM, recent developments
in small molecule FFAR1 (GPR40) agonists reported till now, compounds of natural/plant
origin, recent patents published in the last few years, mechanism of FFAR1 activation by the agonists,
and clinical status of the FFAR1/GPR40 agonists.

Conclusion:
The agonists of FFAR1/GRP40 showed considerable potential for the therapeutic control
of T2DM. Most of the small molecule FFAR1/GPR40 agonists developed were aryl alkanoic acid derivatives
(such as phenylpropionic acids, phenylacetic acids, phenoxyacetic acids, and benzofuran
acetic acid derivatives) and thiazolidinediones. Some natural/plant-derived compounds, including fatty
acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline, and indole alkaloids, were
also reported as potent FFAR1 agonists. The clinical investigations of the FFAR1 agonists
demonstrated their probable role in the improvement of glucose control. Though, there are some
problems still to be resolved in this field as some FFAR1 agonists terminated in the late phase of
clinical studies due to “hepatotoxicity.” Currently, PBI-4050 is under clinical investigation by
Prometic. Further investigation of pharmacophore scaffolds for FFAR1 full agonists as well as multitargeted
modulators and corresponding clinical investigations will be anticipated, which can open up
new directions in this area.
Efficacy of Short Term Topical Malva Sylvestris L. Cream in Pediatric Patients with Atopic Dermatitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial
Authors: Meysami Mahshid , Hashempur Mohammad H. , Kamalinejad Mohammad , Emtiazy Majid 
Published: October 2020

Background:
Atopic dermatitis (AD) is a chronic inflammatory pruritic dermatologic
disease in children. Malva sylvestris L. (M. sylvestris) is a medicinal plant, which is used as a remedy
for eczema in traditional Persian medicine. Previous studies have shown the anti-ulcerogenic
and anti-inflammatory activity of this plant.

Objectives:
We designed a clinical trial to evaluate the efficacy of topical cream of the M. sylvestris
extract in the management of children with AD.

Methods:
Fifty-one children with AD were randomly enrolled in two arms of a randomized, double-
blind, controlled clinical trial. They were treated by topical cream of the M. sylvestris extract or
placebo for a palm-sized surface (single fingertip unit, twice daily) for 4 weeks. The SCORing
Atopic Dermatitis (SCORAD) score was set as the primary outcome measure.

Results:
There was a significant improvement in the severity of participants’ dermatitis regarding
skin thickening score, redness score, and total SCORAD score of the M. sylvestris group as compared
with the placebo group (P= 0.009, P=0.01, and P=0.03; respectively).

Conclusion:
According to the results of this clinical trial, it could be concluded that the topical use
of M. sylvestris extract cream was effective in the reduction of AD symptoms in children.
Trial Registration: This study is registered by the Iranian Registry of Clinical Trials with the code:
IRCT20170107031814N2.
Post-Traumatic Stress Disorder and Associated Factors Among Traumatic Patients Attended in Four Government Hospitals, West Ethiopia
Authors: Golja Eba Abdisa , Labata Busha Gamachu , Mekonen Ginenus Fekadu , Dedefo Mohammed Gebre 
Published: October 2020

Background:
Posttraumatic Stress Disorder is exposure to actual or threatened death that leads to negative alterations in cognitions and mood, and marked change in arousal and reactivity. The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning. Patients’ quality of life decreases in almost every dimension after severe trauma.

Objective:
This study aims to assess the prevalence of post-traumatic stress disorder and its associated factors among fifteen years and above aged patients with traumatic history for more than one month who attended four government hospitals in East Wollega Zone, West Ethiopia.

Methods:
An institutional based cross-sectional study was employed using an interviewer-administered questionnaire. Post-trauma stress disorder symptoms scale was employed to assess the prevalence of post-trauma stress disorder and its associated factors among fifteen years and above aged patients. Study populations were those who had a history of a traumatic injury and attended four government hospitals in East Wollega Zone, West Ethiopia, for more than one month. Study participants were, consecutively, recruited from January to February 2018.

Results:
One hundred ninety-three traumatic patients participated in this study. Male participants accounted for 119 (61.7%) and 82 (42.5%) of respondents aged between 15-26 years. The prevalence of Posttraumatic Stress Disorder in this study was 33 (17.1%). Female traumatic patients were 2.727 times more likely to develop post-traumatic stress disorder than male respondents (AOR= 2.727, 95% CI: 0.431-4.227). Similarly, participants who were found to be involved in substance abuse were 1.65 times (AOR= 1.65, 95% CI: 0.926-2.782) more likely to develop post-traumatic stress disorder than their counterparts. Also, daily laborers were 4.05 times (AOR= 4.05, 95% CI: 0.89-8.76) more likely to develop post-traumatic stress disorder than government employees.

Conclusion:
The prevalence of post-traumatic stress disorder, in this study, was 17.1%. Psychological counseling services offered to female patients, daily laborers, and substance abusers can benefit them as they were significantly associated with the post-traumatic stress disorder.
Using the Patient Portal Sexual Health Instrument in Surveys and Patient Questionnaires Among Sexual Minority Men in the United States: Cross-sectional Psychometric Validation Study
Authors: Jackman Kevon-Mark P , Kane Jeremy , Kharrazi Hadi , Johnson Renee M , Latkin Carl 
Published: October 2020

Background
Patient portal modules, including electronic personal health records, health education, and prescription refill ordering, may be leveraged to address the sexually transmitted infection (STI) burden, including HIV, among gay, bisexual, and other sexual minority men (SMM). Theoretical frameworks in the implementation sciences highlight examining constructs of innovation attributes and performance expectations as key determinants of behavioral intentions and the use of new web-based health technologies. However, behavioral intentions to use patient portals for HIV and other STI prevention and care among SMM is understudied.

Objective
The aim of this study is to develop a brief instrument for measuring attitudes focused on using patient portals for STI prevention and care among a nationwide sample of SMM.

Methods
A total of 12 items of the American Men’s Internet Survey-Patient Portal Sexual Health Instrument (AMIS-PPSHI) were adapted from a previous study. Psychometric analyses of the AMIS-PPSHI items were conducted among a randomized subset of 2018 AMIS participants reporting web-based access to their health records (N=1375). Parallel analysis and inspection of eigenvalues in a principal component analysis (PCA) informed factor retention in exploratory factor analysis (EFA). After EFA, Cronbach α was used to examine the internal consistency of the scale and its subscales. Confirmatory factor analysis (CFA) was used to assess the goodness of fit of the final factor structure. We calculated the total AMIS-PPSHI scale scores for comparisons within group categories, including age, STI diagnosis history, recency of testing, serious mental illness, and anticipated health care stigma.

Results
The AMIS-PPSHI scale resulting from EFA consisted of 12 items and had good internal consistency (α=.84). The EFA suggested 3 subscales: sexual health engagement and awareness (α=.87), enhancing dyadic communication (α=.87), and managing sexual health care (α=.79). CFA demonstrated good fit in the 3-factor PPSHI structure: root mean square error of approximation=0.061, comparative fit index=0.964, Tucker-Lewis index=0.953, and standardized root mean square residual=0.041. The most notable differences were lower scores on the enhanced dyadic communication subscale among people living with HIV.

Conclusions
PPSHI is a brief instrument with strong psychometric properties that may be adapted for use in large surveys and patient questionnaires in other settings. Scores demonstrate that patient portals are favorable web-based solutions to deliver health services focused on STI prevention and care among SMM in the United States. More attention is needed to address the privacy implications of interpersonal use of patient portals outside of traditional health settings among persons with HIV.
Effectiveness, Acceptability, and Feasibility of Digital Health Interventions for LGBTIQ+ Young People: Systematic Review
Authors: Gilbey Dylan , Morgan Helen , Lin Ashleigh , Perry Yael 
Published: October 2020

Background
Young people (aged 12-25 years) with diverse sexuality, gender, or bodily characteristics, such as those who identify as lesbian, gay, bisexual, transgender, intersex, or queer (LGBTIQ+), are at substantially greater risk of a range of mental, physical, and sexual health difficulties compared with their peers. Digital health interventions have been identified as a potential way to reduce these health disparities.

Objective
This review aims to summarize the characteristics of existing evidence-based digital health interventions for LGBTIQ+ young people and to describe the evidence for their effectiveness, acceptability, and feasibility.

Methods
A systematic literature search was conducted using internet databases and gray literature sources, and the results were screened for inclusion. The included studies were synthesized qualitatively.

Results
The search identified 38 studies of 24 unique interventions seeking to address mental, physical, or sexual health–related concerns in LGBTIQ+ young people. Substantially more evidence-based interventions existed for gay and bisexual men than for any other population group, and there were more interventions related to risk reduction of sexually transmitted infections than to any other health concern. There was some evidence for the effectiveness, feasibility, and acceptability of these interventions overall; however, the quality of evidence is often lacking.

Conclusions
There is sufficient evidence to suggest that targeted digital health interventions are an important focus for future research aimed at addressing health difficulties in LGBTIQ+ young people. Additional digital health interventions are needed for a wider range of health difficulties, particularly in terms of mental and physical health concerns, as well as more targeted interventions for same gender–attracted women, trans and gender-diverse people, and people with intersex variations.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020128164; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=128164
Evaluation of a Remote Symptom Assessment and Management (SAM) System for People Receiving Adjuvant Chemotherapy for Breast or Colorectal Cancer: Mixed Methods Study
Authors: Whitehead Lisa , Emery Laura , Kirk Deborah , Twigg Diane , Brown Deborah , Dewar Joanna 
Published: October 2020

Background
The Symptom Assessment and Management (SAM) program is a structured, online, nurse-supported intervention to support symptom self-management in people receiving adjuvant chemotherapy post surgery for breast or colorectal cancer.

Objective
The objective of this study was to describe the development, implementation strategy, and evaluation of the SAM system.

Methods
The development of the SAM program involved 3 phases. In phase 1, the web app was developed through consultation with consumers and clinicians and of the literature to ensure that the system was evidence-based and reflected the realities of receiving treatment and supporting patients through treatment. In phase 2, 7 participants recorded the severity of 6 symptoms daily over the course of 1 cycle of chemotherapy. In phase 3, 17 participants recorded their symptoms daily over the course of 3 cycles of chemotherapy. Once symptoms were recorded, participants received immediate feedback on the severity of their symptoms and self-management recommendations, which could include seeking immediate medical attention. Data on quality of life, symptom burden, anxiety and depression, distress, and self-efficacy were collected during treatment; participants’ perceptions of the SAM program were evaluated following participation via interview.

Results
The outcomes of the SAM project include the development of a system that is reliable and easy to use and navigate. Participants reported benefits related to using the SAM program that included feeling more in control of managing their symptoms and feeling reassured. Engagement with the system on a daily basis was variable, with some participants completing the symptom tracker daily and others engaging some of the time. The feedback from all participants was that the system was easy to navigate and the information was relevant and supportive.

Conclusions
The SAM program has the potential to enhance the management of symptoms for people receiving chemotherapy treatment. The system creates an accurate repository of symptoms that can be accessed easily and highlight patterns in symptom experience. These can be shared with clinicians, with patient permission, to inform and support treatment plans. The potential to predict the risk of developing severe symptoms can be developed to anticipate the need for care and support. Further considerations on how to increase engagement with the system, the value of the system for people diagnosed with other tumor types and treatment regimes, and the incorporation of the system into everyday clinical practice are needed.
Geologia do Complexo Intrusivo Santa Angélica no Orógeno Araçuaí, Estado do Espírito Santo: perspectivas para o setor de rochas ornamentais
Authors: HARTWIG Marcos Eduardo , De MELO Marilane Gonzaga , PETERLE Daniel Tonini , FEUCHARD Lucas David 
Published: October 2020

O Complexo Intrusivo Santa Angélica (CISA) é um corpo intrusivo cálcio-alcalino pós-colisional alojado em ortognaisses pré-colisionais da Supersuíte G1 e em rochas paraderivadas do Complexo Paraíba do Sul, durante a orogênese Brasiliana-Panafricana, que originou o Cinturão Araçuaí-Congo Ocidental. Trata-se de um corpo com formato elíptico inversamente zonado, que contém dois núcleos de rochas gabro-dioríticas e bordas nas quais afloram rochas graníticas megaporfiríticas, separadas por uma ampla zona de mistura de magmas. Atualmente, a maioria dos levantamentos geológicos básicos disponíveis sobre o CISA foram produzidos em escala inferior a 1:50.000. Neste sentido, o objetivo do presente estudo foi o de gerar um mapa geológico do CISA em escala 1:25.000 e subsidiar o setor de prospecção de rochas ornamentais, utilizando-se de técnicas clássicas de mapeamento geológico. Os dados revelaram importantes diferenças na área e distribuição de algumas unidades de mapeamento indicadas em estudos anteriores. As feições de campo e microscópicas revelaram diversas feições de mistura mecânica de magmas. Os dados analisados sugerem que as zonas de cisalhamento dextrais Guaçuí e Batatal influenciaram no posicionamento do CISA. A unidade denominada como rocha híbrida pode representar um interessante material para o setor produtivo de rocha ornamental, tendo em vista a sua grande heterogeneidade, que lhe confere características estéticas únicas.
PREPARATION OF QUALIFIED SPECIALISTS FOR AGRICULTURAL PRODUCTION
Authors: Лепешкина Анна Борисовна 
Published: October 2020

Представлен авторский взгляд на подготовку квалифицированных специалистов для сельскохозяйственного производства. Рассмотрена экономико-управленческая подготовка квалифицированных специалистов для сельскохозяйственного производства с учетом стандарта World Skills Russia по направлению подготовки «Механизация сельского хозяйства» на примере среднего профессионального образования. Описывается авторская модель подготовки квалифицированных специалистов по специальности «Механизация сельского хозяйства». Приводится спецификация стандарта World Skills по компетенции «Эксплуатация сельскохозяйственных машин». Описывается внедрение данной спецификации в образовательный процесс ОГБПОУ «Томский аграрный колледж». Рассматривается процесс организации учебных занятий. Связь преподавания с жизнью, сельскохозяйственным производством – это не только использование материалов об историческом пути сельскохозяйственной науки и практики, но и рассмотрение актуального вопроса как необходимость знания экономики, организации и планирования сельскохозяйственного производства. Задача преподавателя заключается в том, чтобы применять экономические знания на практике, например при изучении сельскохозяйственной техники, то есть машин и механизмов, уметь определять эффективность применения машин, удобрений, ядохимикатов и т. д. Таким образом, в деле профессиональной подготовки обучающихся важно, чтобы в содержание занятий включался конкретный материал, направленный на развитие у обучающихся интереса к избранной специальности.
The article presents the author’s view on the training of qualified specialists for agricultural production. The economic and managerial training of qualified specialists for agricultural production is considered taking into account the World Skills Russia standard in the field of training “Agricultural mechanization” using the example of secondary vocational education. The author describes the model of training qualified specialists in the specialization «Agricultural Mechanization». The specification of the World Skills standard on the competence “Operation of agricultural machines” is given. The introduction of this specification in the educational process of OGBPOU «Tomsk Agrarian College» is described. The process of organizing training sessions is considered. The connection of teaching with life, with agricultural production is not only the use of materials about the historical path of agricultural science and practice, but the consideration of an urgent issue as the need for knowledge of the economy, organization and planning of agricultural production. The teacher’s task is to apply economic knowledge in practice, for example, in the study of agricultural machinery, that is, machines and mechanisms, to be able to determine the effectiveness of the use of machines, fertilizers, pesticides, etc. Thus, in the matter of training students, it is important that the content of classes include specific material aimed at developing students’ interest in their chosen specialty.
DEVELOPMENT OF SELF-REGULATING SKILLS AND SPIRITUAL AND MORAL QUALITIES IN CHILDREN
Authors: Машарина Александра Федоровна 
Published: October 2020

Подчеркивается важность развития у детей духовно-нравственных качеств в процессе оздоровительно-развивающего обучения саморегуляции. Сравнивается влияние двух программ развития саморегуляции на физическое и психологическое состояние детей дошкольного и младшего школьного возраста: 1) программа формирования саморегуляционных умений на основе занятий древневосточной оздоровительной практикой ушу (акцент на физическое и духовно-нравственное развитие); 2) программа формирования саморегуляционных умений на основе занятий древневосточной оздоровительной практикой ушу (акцент на физическое развитие). Результаты проведенного исследования показали, что программа 1 – обучение саморегуляции с обращением к актуализации духовно-нравственных качеств – позволила детям прогрессировать гораздо в большей степени, чем программа 2, связанная с развитием саморегуляционных умений только на физическом уровне. В первом случае дети развивались более активно как по физическим характеристикам (сила, выносливость, гибкость, координация), так и личностным параметрам (мотивация к учебе, адаптация к следующему важному жизненному этапу, дисциплинированность, инициативность, чувствительность к воздействиям сверстников, эмоциональный фон).
The article emphasizes the importance of developing children’s spiritual and moral qualities in the process of improving and developing self-regulation training and the formation of children’s self-regulating skills using the ancient Eastern health practice of Wushu. The influence of two programs of self-regulation development on the physical and psychological state of preschool and primary school children is compared: 1) the program for the formation of self-regulating skills based on the ancient Eastern health practice of Wushu (emphasis on physical and spiritual and moral development); 2) the program for the formation of selfregulating skills based on the ancient Eastern health practice of Wushu (emphasis on physical development). The pilot study uses the method of psychophysical development of children using traditional elements of Wushu T. N. Bruk. The comparison is based on the indicators evaluated by the methods: E. O. Smirnova and V. M. Kholmogorova, assessment of physical development. The results of the study showed that program 1 – self-regulation training with reference to the actualization of spiritual and moral qualities allowed children to progress much more than program 2, which is associated with the development of self-regulation skills only at the physical level. In the first case, children developed more actively both in terms of physical characteristics (strength, endurance, flexibility, coordination) and personal parameters (motivation to study, discipline, initiative, sensitivity to peer influences, emotional background).