bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Mental Health First Aid Training to Improve the Mental Health Literacy of Physiotherapy Students
Authors: Edgar Susan , Connaughton Joanne 
Published: June 2020

Purpose: Mental Health First Aid (MHFA) training has been proven to improve the literacy of trainees and reduce the stigma they may have toward individuals with mental health problems in the general population. Our research was designed to determine whether MHFA training had an impact on physiotherapy students’ attitudes toward psychiatry and mental illness, their confidence to engage with people with mental health problems, and their preparedness for practice. Method: Final-year students from one university who had finished MHFA training completed a questionnaire that included the Attitudes Toward Psychiatry–30 and questions about their perceived confidence in working with people with mental illness and preparedness for practice. Their responses were compared with those from a previous cohort of students at the same point in their university education who had not completed MHFA training. Results: The students who had completed MHFA training (response rate 83%) had a more positive attitude toward psychiatry and mental illness than those who had not ( p < 0.001). Their confidence in treating people with mental health problems also increased, and to a statistically significant extent ( p < 0.001). Conclusions: MHFA training appeared to improve students’ attitudes toward psychiatry and mental health, increase their confidence in treating people with mental health problems, and better prepare them for practice.
Implementierung von unternehmensübergreifender Traceability
Authors: Benfer Martin , Gartner Patrizia , Treber Stefan , Kuhnle Andreas , Häfner Benjamin , Lanza Gisela 
Published: June 2020

Kurzfassung
Die Nachverfolgbarkeit (engl. traceability) von Produkten entlang ihres Lebenszyklus ist eine Grundvoraussetzung für zahlreiche Anwendungsfelder: der Ermöglichung von Kreislaufwirtschaftsprozessen, dem Schutz vor Produktpiraterie und der zielgerichteten Qualitätssicherung. Jedoch existieren über die gesetzlich vorgeschriebenen Standards hinaus wenig umfassende Lösungen, um Produkte unternehmensübergreifend nachzuverfolgen. Dieser Beitrag zeigt ein Konzept zur strukturierten Konzeption, Implementierung und Bewertung solcher Traceability-Systeme.
Supply-Chain-Management 4.0
Authors: Pause Daniel , Holtkemper David , Kraut Andreas , Marek Svenja , Janßen Jokim , Linnartz Maria , Schmitz Sebastian 
Published: June 2020

Kurzfassung
Viele Unternehmen erhoffen sich enorme Wachstumschancen durch Digitalisierung, Vernetzung und neue Technologien. Daher ist der Reifegrad der Digitalisierung eines Unternehmens von besonderer Bedeutung, um den Status des Unternehmens zu überprüfen. Im Rahmen der acatech-Studie wurde ein Index entwickelt, um den Reifegrad von produzierenden Unternehmen zu bestimmen. Diese Bewertung berücksichtigt jedoch den Bereich des Lieferkettenmanagements nicht ausreichend. Infolgedessen müssen diesbezüglich weitere Merkmale entwickelt werden, um den Reifegrad der Digitalisierung innerhalb einer Lieferkette zu bestimmen. Der Schwerpunkt liegt auf Datenverarbeitung, Kommunikation, Schnittstellenarbeit und Sicherheit, Netzwerkzusammenarbeit und Änderungsmanagement.
XRD investigation of the Cu and Mn effects on the oxide scale of hot rolled AISI 304L stainless steel after annealing and shot-blasting
Authors: Lothongkum Gobboon , Tiyawatwitthaya Chockanan , Prawetpai Nipa , Lothongkum Anchaleeporn W. 
Published: June 2020

Abstract
The oxide scales of hot-rolled, annealed hot-rolled, and shot blasted annealed hot-rolled AISI 304L stainless steel with 0.2-0.4 wt.-%Cu and 1.0-1.7 wt.-%Mn were investigated by XRD. Mn but not Cu showed its effects on the oxide compounds. In the hot-rolled state, the oxide compounds consisted of Fe2O3 and Cr1.5Mn1.5O4 in all tested steels. Mn-rich (Fe,Mn)2SiO4 was found in the oxide of the tested steel with 1.2 wt.-%Mn while Mn3O4 was found in the oxide of the tested steel with 1.7 wt.-%Mn. The addition of Mn promoted the formations of Cr1.5Mn1.5O4, Mn-rich (Fe,Mn)2SiO4 and Mn3O4. The oxide compounds developed from Fe2O3 to (Fe0.6Cr0.4)2O3 or Cr1.3Fe0.7O3, Cr1.5Mn1.5O4 to CrMn2O4 and Mn-rich (Fe,Mn)2SiO4 to (Fe,Mn)2SiO4 after the annealing process. The shot blasting process of annealed hot-rolled 304L stainless steel descaled the outer oxides as (Fe0.6Cr0.4)2O3 and (Fe,Mn)2SiO4 and revealed the inner oxides Cr1.3Fe0.7O3, CrMn2O4 and Cr2O3. The results clearly showed that the fraction of CrMn2O4 increased according to the Mn content.
A physically based material model for the simulation of friction stir welding
Authors: Panzer Florian , Shishova Elizaveta , Werz Martin , Weihe Stefan , Eberhard Peter , Schmauder Siegfried 
Published: June 2020

Abstract
A physically based material model, taking into account the interdependence of material microstructure and yield strength, is presented for an Al 5182 series aluminum alloy for the simulation of friction stir welding using continuum mechanics approaches. A microstructure evolution equation considering dislocation density and grain size is used in conjunction with a description of yield stress. In order to fit experimental stress-strain curves, obtained from compression tests at various strain rates and temperatures, phenomenological relationships are developed for some of the model parameters. The material model is implemented in smoothed particle hydrodynamic research code as well as in the commercial finite element code Abaqus. Simulations for various strain rates and temperatures were performed and compared with experimental results as well as between the two discretization methods in order to verify the material model and the implementation. Simulations provide not only an accurate approximation of stress based on temperature, strain rate, and strain but also an improved insight into the microstructural evolution of the material.
Mechanical behavior and failure mechanism of three-dimensional braided composites at different temperatures
Authors: Jiang Weimin , Zhou Junmeng , Mei Jie , Liu Jiayi , Huang Wei 
Published: June 2020

Abstract
This investigation explored the effect of temperature on the compressive behaviors and failure mechanism of three dimensional (3D) carbon/ epoxy five-directional braided composite laminates. The compression tests of 3D braided composite laminates were performed at six different temperatures, which are 20 °C (room temperature), 50 °C, 70 °C, 90 °C, 110 °C and 130 °C, respectively. Then the effect of temperature on the failure mechanism, stress-strain curves, compressive modulus and strength of the composite laminates were analyzed and compared to that at room temperature. The results have shown that the temperature had a significant effect on the compressive properties and failure mechanism of 3D braided composite laminates. At 20 °C and 50 °C, the 3D braided composite laminates failed by shear fracture, and the stress-strain curves exhibited obvious linear elasticity and a brittle failure feature. While, at higher temperatures (70 °C, 90 °C, 110 °C and 130 °C), it was found that the specimens exhibited obvious plastic kinking, and the stress-strain curves exhibited obvious non-linear trend and a plastic failure feature due to the epoxy resin matrix becoming softened and plastic. The compressive modulus and strength decreased as temperature increased. The compressive modulus and strength decreased by 92.3 % and 93.8 % when the temperature increased from 20 °C to 130 °C.
Seagull optimization algorithm for solving real-world design optimization problems
Authors: Panagant Natee , Pholdee Nantiwat , Bureerat Sujin , Kaen Khon , Yıldız Ali Rıza , Sait Sadiq M. 
Published: June 2020

Abstract
In this research paper, a new surrogate-assisted metaheuristic for shape optimization is proposed. A seagull optimization algorithm (SOA) is used to solve the shape optimization of a vehicle bracket. The design problem is to find structural shape while minimizing structural mass and meeting a stress constraint. Function evaluations are carried out using finite element analysis and estimated by using a Kriging model. The results show that SOA has outstanding features just as the whale optimization algorithm and salp swarm optimization algorithm for designing optimal components in the industry.
Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution
Authors: Haddad Alexander F. , Young Jacob S. , Oh Taemin , Pereira Matheus P. , Joshi Rushikesh S. , Pereira Kaitlyn M. , Osorio Robert C. , Donohue Kevin C. , Peeran Zain , Sudhir Sweta , Jain Saket , Beniwal Angad , Chopra Ashley S. , Sandhu Narpal S. , Theodosopoulos Philip V. , Kunwar Sandeep , El-Sayed Ivan H. , Gurrola José , Blevins Lewis S. , Aghi Manish K. 
Published: June 2020

OBJECTIVENonfunctioning pituitary adenomas present without biochemical or clinical signs of hormone excess and are the second most common type of pituitary adenomas. The 2017 WHO classification scheme of pituitary adenomas differentiates null-cell adenomas (NCAs) and silent gonadotroph adenomas (SGAs). The present study sought to highlight the differences in patient characteristics and clinical outcomes between NCAs and SGAs.METHODSThe records of 1166 patients who underwent transsphenoidal surgery for pituitary adenoma between 2012 and 2019 at a single institution were retrospectively reviewed. Patient demographics and clinical outcomes were collected.RESULTSOf the overall pituitary adenoma cohort, 12.8% (n = 149) were SGAs and 9.2% (n = 107) NCAs. NCAs were significantly more common in female patients than SGAs (61.7% vs 26.8%, p < 0.001). There were no differences in patient demographics, initial tumor size, or perioperative and short-term clinical outcomes. There was no significant difference in the amount of follow-up between patients with NCAs and those with SGAs (33.8 months vs 29.1 months, p = 0.237). Patients with NCAs had significantly higher recurrence (p = 0.021), adjuvant radiation therapy usage (p = 0.002), and postoperative diabetes insipidus (p = 0.028). NCA pathology was independently associated with tumor recurrence (HR 3.64, 95% CI 1.07–12.30; p = 0.038), as were cavernous sinus invasion (HR 3.97, 95% CI 1.04–15.14; p = 0.043) and anteroposterior dimension of the tumor (HR 2.23, 95% CI 1.09–4.59; p = 0.030).CONCLUSIONSThis study supports the definition of NCAs and SGAs as separate subgroups of nonfunctioning pituitary adenomas, and it highlights significant differences in long-term clinical outcomes, including tumor recurrence and the associated need for adjuvant radiation therapy, as well as postoperative diabetes insipidus. The authors also provide insight into independent risk factors for these outcomes in the adenoma population studied, providing clinicians with additional predictors of patient outcomes. Follow-up studies will hopefully uncover mechanisms of biological aggressiveness in NCAs and associated molecular targets.
PET-guided repeat transsphenoidal surgery for previously deemed unresectable lateral disease in acromegaly
Authors: Bashari Waiel A. , Senanayake Russell , Koulouri Olympia , Gillett Daniel , MacFarlane James , Powlson Andrew S. , Fernandez-Pombo Antia , Bano Gul , Martin Andrew J. , Scoffings Daniel , Cheow Heok , Mendichovszky Iosif , Tysome James , Donnelly Neil , Santarius Thomas , Kolias Angelos , Mannion Richard , Gurnell Mark 
Published: June 2020

OBJECTIVEThe object of this study was to determine if revision transsphenoidal surgery (TSS), guided by 11C-methionine PET/CT coregistered with volumetric MRI (Met-PET/MRCR), can lead to remission in patients with persistent acromegaly due to a postoperative lateral disease remnant.METHODSThe authors identified 9 patients with persistent acromegaly following primary intervention (TSS ± medical therapy ± radiotherapy) in whom further surgery had initially been discounted because of equivocal MRI findings with suspected lateral sellar and/or parasellar disease (cases with clear Knosp grade 4 disease were excluded). All patients underwent Met-PET/MRCR. Scan findings were used by the pituitary multidisciplinary team to inform decision-making regarding repeat surgery. Revision TSS was performed with wide lateral exploration as guided by the PET findings. Endocrine reassessment was performed at 6–10 weeks after surgery, with longitudinal follow-up thereafter.RESULTSMet-PET/MRCR revealed focal tracer uptake in the lateral sellar and/or parasellar region(s) in all 9 patients, which correlated with sites of suspected residual tumor on volumetric MRI. At surgery, tumor was identified and resected in 5 patients, although histological analysis confirmed somatotroph tumor in only 4 cases. In the other 4 patients, no definite tumor was seen, but equivocal tissue was removed. Despite the uncertainty at surgery, all patients showed immediate significant improvements in clinical and biochemical parameters. In the 8 patients for whom long-term follow-up data were available, insulin-like growth factor 1 (IGF-1) was ≤ 1.2 times the upper limit of normal (ULN) in all subjects and ≤ 1 times the ULN in 6 subjects, and these findings have been maintained for up to 28 months (median 8 months, mean 13 months) with no requirement for adjunctive medical therapy or radiotherapy. No patient suffered any additional pituitary deficit or other complication of surgery.CONCLUSIONSThis study provides proof of concept that Met-PET/MRCR can be helpful in the evaluation of residual lateral sellar/parasellar disease in persistent acromegaly and facilitate targeted revision TSS in a subgroup of patients.
Machine learning–based prediction of outcomes of the endoscopic endonasal approach in Cushing disease: is the future coming?
Authors: Zoli Matteo , Staartjes Victor E. , Guaraldi Federica , Friso Filippo , Rustici Arianna , Asioli Sofia , Sollini Giacomo , Pasquini Ernesto , Regli Luca , Serra Carlo , Mazzatenta Diego 
Published: June 2020

OBJECTIVEMachine learning (ML) is an innovative method to analyze large and complex data sets. The aim of this study was to evaluate the use of ML to identify predictors of early postsurgical and long-term outcomes in patients treated for Cushing disease (CD).METHODSAll consecutive patients in our center who underwent surgery for CD through the endoscopic endonasal approach were retrospectively reviewed. Study endpoints were gross-tumor removal (GTR), postsurgical remission, and long-term control of disease. Several demographic, radiological, and histological factors were assessed as potential predictors. For ML-based modeling, data were randomly divided into 2 sets with an 80% to 20% ratio for bootstrapped training and testing, respectively. Several algorithms were tested and tuned for the area under the curve (AUC).RESULTSThe study included 151 patients. GTR was achieved in 137 patients (91%), and postsurgical hypersecretion remission was achieved in 133 patients (88%). At last follow-up, 116 patients (77%) were still in remission after surgery and in 21 patients (14%), CD was controlled with complementary treatment (overall, of 131 cases, 87% were under control at follow-up). At internal validation, the endpoints were predicted with AUCs of 0.81–1.00, accuracy of 81%–100%, and Brier scores of 0.035–0.151. Tumor size and invasiveness and histological confirmation of adrenocorticotropic hormone (ACTH)–secreting cells were the main predictors for the 3 endpoints of interest.CONCLUSIONSML algorithms were used to train and internally validate robust models for all the endpoints, giving accurate outcome predictions in CD cases. This analytical method seems promising for potentially improving future patient care and counseling; however, careful clinical interpretation of the results remains necessary before any clinical adoption of ML. Moreover, further studies and increased sample sizes are definitely required before the widespread adoption of ML to the study of CD.
Repair of the sellar floor using bioresorbable polydioxanone foils after endoscopic endonasal pituitary surgery
Authors: Zeden Jan-Philip , Baldauf Jörg , Schroeder Henry W. S. 
Published: June 2020

OBJECTIVEPostoperative CSF leakage is the most common unwanted sequela of transnasal pituitary surgery. The individual anatomy, the extent of the sellar opening, and the occurrence of an intraoperative CSF leak add to the risk of postoperative rhinorrhea. Despite the current sophistication and recent developments in pituitary surgery, watertight closure of the sellar floor remains a matter of concern. Improvements and additions to the technical armamentarium of sellar reconstruction are therefore still desirable.METHODSThe authors present a closure technique of the sellar floor using a bioresorbable polydioxanone foil, which is placed between the dura and the bony margins of the open sellar floor to keep the intrasellar implants in place and to withstand the pressure arising from the intracranial compartment.RESULTSThe technique was used in a technical case series of 30 patients, and in all patients the floor could be sufficiently reconstructed. CSF flow intraoperatively was documented in 10 cases (33.3%). Postoperative CSF rhinorrhea was detected in one patient (3.3%). No complications could be attributed to the technique or the material during a mean follow-up period of 477 days. The foils can easily be identified on MR images and CT scans and therefore do not affect the postoperative radiological assessment.CONCLUSIONSThe described technique is an easy, inexpensive, and reliable method for sellar floor reconstruction and has a low CSF leakage rate. It is recommended when the risk of a postoperative CSF leak is high and there is still enough bony margin of the sellar floor left that enables a sufficient fixation of the foil.
Surgical outcomes and multidisciplinary management strategy of Cushing’s disease: a single-center experience in China
Authors: Zhang Keyi , Shen Ming , Qiao Nidan , Chen Zhengyuan , He Wenqiang , Ma Zengyi , Shou Xuefei , Li Shiqi , Zhao Yao , Pan Li , Liu Dan , He Min , Zhang Zhaoyun , Li Yiming , Yao Zhenwei , Ye Hongying , Wang Yongfei 
Published: June 2020

OBJECTIVEThe primary aim of this study was to investigate the value of multidisciplinary team (MDT) management in treating patients with Cushing’s disease (CD). The secondary aim was to assess the concordance of bilateral inferior petrosal sinus sampling (BIPSS) lateralization with intraoperative observations.METHODSThe authors recruited 124 consecutive patients (128 procedures) who had undergone endoscopic endonasal resection of adrenocorticotropic hormone–secreting pituitary adenomas from May 2014 to April 2018 and assessed their clinical characteristics, surgical outcomes, and adjuvant therapies. The criteria for surgical remission were normalized serum and urinary cortisol levels, which could be suppressed by a low-dose dexamethasone suppression test at 3-months’ follow-up without adjuvant treatment.RESULTSThe remission rates of the 113 patients with long-term follow-up (20.3 ± 12.2 months) were 83.2% after surgery alone and 91.2% after adjuvant therapy. The surgical remission rates of macroadenomas, MRI-visible microadenomas, and MRI-negative tumors were 66.7% (12/18), 89.3% (67/75), and 75% (15/20), respectively (p = 0.039). The surgical remission rates had a trend of improvement during the study period (87.5% in 2017–2018 vs 76.5% in 2014, p = 0.517). Multivariate regression analysis showed that a history of previous pituitary surgery (OR 0.300, 95% CI 0.100–0.903; p = 0.032) and MRI-visible microadenoma (OR 3.048, 95% CI 1.030–9.019; p = 0.044) were independent factors influencing surgical remission. The recurrence rate was 3.2% after a mean of 18 months after surgery. The remission rate of postoperative MDT management in patients with persistent disease was higher than non-MDT management (66.7% vs 0%, p = 0.033). In cases with preoperative BIPSS lateralization, 84.6% (44/52) were concordant with intraoperative findings.CONCLUSIONSMRI-visible microadenoma and primary surgery were independent predictors of surgical remission in CD. The MDT management strategy helps to achieve a better overall outcome. BIPSS may help to lateralize the tumor in MRI-negative/equivocal microadenomas.
The Effectiveness of Classical Music Therapy and Progressive Muscle Relaxation Therapy on Anxiety Levels
Authors: Agni Jeny Ayu Ratri Semara , Sarwono Bambang , Suyanta Suyanta 
Published: June 2020

Background : Anxiety occurs when a person has difficulty in dealing with situations, problems and goals. One example of anxiety's situation is the anxiety experienced by students who will face the exam, the exam itself is an evaluation to assess the learning that has given the teachers to its students, the evaluation been assessed through exams. Efforts to reduced the anxiety one of them with progressive muscle relaxation therapy in which the body's response to anxiety will affect the mind and muscle tension. Then there is also an effort to decrease anxiety with music therapy to help express feelings and a positive influence on the condition and emotionsMethods : This research was conduct in March 2019, methods used quasy experimental design with time series approach. Instrument used to measure the level of anxiety with BAI (Beck Anxiety Inventory). Sampling technique using accidental sampling, with a sample of 40 respondents.Results : Statistical test results using independent t-test with p value 0,019 the first day, second day and third day 0.002 0.022 (p 0.05), which means there is a difference, then the average value obtained showed the lowest value between music therapy and therapy progressive muscle relaxation, which means no difference in effectiveness.Conclusion : There are differences in effectiveness where progressive muscle relaxation therapy is more effective than the classic music therapy in reducing anxiety levels in high school.
VENA KAVA SÜPERİOR SENDROMUYLA TANI ALAN YÜKSEK DERECELİ NÖROENDOKRİN KARSİNOM: OLGU SUNUMU
Authors: KOLKIRAN Nagihan , GÖKSEL Gamze , EKİNCİ Ferhat , ERDOĞAN Atike Pınar , DİRİCAN Ahmet , GÖKTAN Cihan 
Published: June 2020

Nöroendokrin
tümörler başta akciğer ve gastrointestinal sistem olmak üzere tüm vücutta
görülebilen nadir tümörlerdir.(1,2)
Akciğer karsinomlarının %20 ‘sini oluşturur.(1,2) Akciğer nöroendokrin
tümörlerde vena kava süperior sendromu (VKSS) sıklığı bilinmemektedir. İntratorasik
maligniteler VKSS’nin %60-%85’inden sorumludur ve tümör tanısı önceden konulmamış
bu olguların %60 ‘ı vena kava superior obstrüksiyonu ile prezente olur. Bu
olgularda venöz obstrüksiyon; vena kava süperiora primer tümörün, mediastinal
lenf nodlarının dıştan basısı veya direk
tümör invazyonu sonucunda meydana gelir. Literatürde sağkalım verileri olgu
sunumu düzeyinde olmakla birlikte tedavisiz kalan olgularda sağkalım 1 ay
civarında bildirilmektedir. Bu nedenle hızlı tanı konulup uygun tedavinin
planlanması hayati önem taşımaktadır. Burada akciğer nöroendokrin tümör
nedeniyle VKSS gelişen olgunun tanısal süreci ve prognozu sunulmuştur.