bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results after arthroscopic treatment of iliopsoas impingement after total hip arthroplasty
Authors: Zimmerer A. , Hauschild M. , Nietschke R. , Schneider M. M. , Wassilew G. , Sobau C. , Miehlke W. 
Published: October 2020

Abstract
Background
A cause of groin pain after total hip arthroplasty (THA) is mechanical irritation or impingement of the iliopsoas tendon. The incidence is about 4%. If conservative therapy fails, an arthroscopic release of the iliopsoas tendon can be performed. The aim of the study was to assess the mid-term clinical outcome after arthroscopic release. We hypothesize that good results can be achieved by a minimally invasive endoscopic procedure.

Methods
Using our in-house database, all patients who received an endoscopic release of the iliopsoas tendon due to mechanical irritation after THA were identified. Inclusion criteria were mechanical irritation of the iliopsoas tendon after cementless THA with minimal acetabular component prominence. Exclusion criteria were marked prominence of the acetabular component and groin pain after THA for any other reason. In these patients, the modified Harris Hip Score (mHHS), the pain level using the numerical analogue scale and the UCLA Activity Score were measured. The mean follow-up period was 7 ± 3.8 (2.6–11.7) years.

Results
25 patients were identified in whom an arthroscopic release of the iliopsoas tendon had been performed since 2007. The data of 20 patients were available at follow-up. The gender ratio was 1:1, the average age at the time of arthroscopy was 59 ± 27.7 (52–78) years. The average interval between THA and arthroscopy was 6.3 ± 4.0 (1.7–15) years. The mHHS showed a significant improvement from preoperative 31.2 ± 9.8 (17.6–47.3) to 82.0 ± 9.8 (46.2–100) points (p = 0.001). The pain level on the NAS decreased significantly from 8.5 ± 1.2 (7–10) to 2.5 ± 1.8 (0–6) points (p = 0.001). The activity level based on the UCLA Activity Score raised from 4.0 ± 2.7 (0–7) to 6.5 ± 1.8 (3–9) (p = 0.09).

Conclusion
Mechanical irritation and impingement of the iliopsoas tendon is an important diagnosis to be considered in persistent groin pain after total hip arthroplasty. In failure of non-operative treatment, good clinical results can be achieved with arthroscopic release and the pain level can be significantly reduced.

Level of evidence
IV.
Individualized blended care for patients with colorectal cancer: the patient’s view on informational support
Authors: Islind Anna Sigridur , Johansson Victoria , Vallo Hult Helena , Alsén Pia , Andreasson Emma , Angenete Eva , Gellerstedt Martin 
Published: October 2020

Abstract
Purpose
The number of colorectal cancer patient survivors is increasing. Information and support during and after treatment are requested by patients, but questions remain on what to provide. The aim of this study was to understand what informational needs colorectal cancer patients and survivors have, with a focus on the potential support given by patient peers and the use of blended care.

Methods
A qualitative study using focus groups was conducted with patients diagnosed at the same hospital at least one year prior to the initiation of the study. The focus group interviews were transcribed verbatim and analyzed using deductive content analysis.

Results
The need for informational support varied over time and depended on individual patient characteristics. Timing was crucial and patients requested options of blended care and informational support after treatment cessation. The patients felt alone after treatment and requested assistance in communication with their next-of-kin. They also identified the value of peer support, especially to contextualize knowledge provided by healthcare.

Conclusion
This study showed a need for focus on individualized informational support. Blended care through integrating communication with peers online could be one way to support patients, both to enable shared decision-making as well as to provide person-centered care.
Comparative study of hyperpure chlorine dioxide with two other irrigants regarding the viability of periodontal ligament stem cells
Authors: Láng Orsolya , Nagy Krisztina S. , Láng Julia , Perczel-Kovách Katalin , Herczegh Anna , Lohinai Zsolt , Varga Gábor , Kőhidai László 
Published: October 2020

Abstract
Objectives
Periodontal ligament stem cells (PDLSCs) have an underlined significance as their high proliferative capacity and multipotent differentiation provide an important therapeutic potential. The integrity of these cells is frequently disturbed by the routinely used irrigative compounds applied as periodontal or endodontic disinfectants (e.g., hydrogen peroxide (H2O2) and chlorhexidine (CHX)). Our objectives were (i) to monitor the cytotoxic effect of a novel dental irrigative compound, chlorine dioxide (ClO2), compared to two traditional agents (H2O2, CHX) on PDLSCs and (ii) to test whether the aging factor of PDLSC cultures determines cellular responsiveness to the chemicals tested.

Methods
Impedimetry (concentration-response study), WST-1 assays (WST = water soluble tetrazolium salt), and morphology analysis were performed to measure changes in cell viability induced by the 3 disinfectants; immunocytochemistry of stem cell markers (STRO-1, CD90, and CD105) measured the induced mesenchymal characteristics.

Results
Cell viability experiments demonstrated that the application of ClO2 does not lead to a significant decrease in viability of PLDSCs in concentrations used to kill microbes. On the contrary, traditional irrigants, H2O2, and CHX are highly toxic on PDLSCs. Aging of PLDSC cultures (passages 3 vs. 7) has characteristic effects on their responsiveness to these agents as the increased expression of mesenchymal stem cell markers turns to decreased.

Conclusions and clinical relevance
While the active ingredients of mouthwash (H2O2, CHX) applied in endodontic or periodontitis management have a serious toxic effect on PDLSCs, the novel hyperpure ClO2 is less toxic providing an environment favoring dental structure regenerations during disinfectant interventions.
Accessibility to biologics and its impact on disease activity and quality of life in patients with rheumatoid arthritis in Kuwait
Authors: Al-Herz Adeeba , Saleh Khuloud , Al-Awadhi Adel , Al-Kandari Waleed , Hasan Eman , Ghanem Aqeel , Hussain Mohammed , Ali Yaser , Nahar Ebrahim , Alenizi Ahmad , Hayat Sawsan , Abutiban Fatemah , Aldei Ali , Alhajeri Hebah , Alhadhood Naser , Bahbahani Husain , Tarakmeh Hoda , Mokaddem Khaled , Khadrawy Ahmad , Fazal Ammad , Zaman Agaz , Mazloum Ghada , Bartella Youssef , Hamed Sally , Alsouk Ramia , Al-Saber Ahmed ,   Kuwait Registry for Rheumatic Diseases (KRRD)
Published: October 2020

Abstract
Objective
Biologics are indicated in rheumatoid arthritis (RA) in case of persistent high disease activity despite conventional disease-modifying anti-rheumatic drugs (cDMARDs) or patients with contraindications to cDMARDs or poor prognostic factors. The purpose of this study was to compare the prescription rates of biologics in Kuwaiti and non-Kuwaiti patients and to assess whether this had an impact on disease activity and quality of life in RA patients.

Methods
Data were extracted from the Kuwait Registry for Rheumatic Diseases. Adult patients who satisfied the ACR classification criteria for RA from four major hospitals in Kuwait were evaluated from February 2013 through May 2018. The treatment agents, disease activity, and quality of life of Kuwaiti patients were compared with non-Kuwaiti patients.

Results
A total of 1651 RA patients were included; 806 (48.8%) were Kuwaiti patients. Among Kuwaiti patients, 62.5% were on biologic drugs in comparison with 14% of non-Kuwaiti patients. In comparison with non-Kuwaiti patients, Kuwaiti patients had significantly lower numbers of swollen joints (p < 0.001) and disease activity score-28 scores (p = 0.02) and less steroid use (p < 0.001) yet a significantly higher health assessment questionnaire-disability index (p < 0.001). Regression analysis showed that DAS-28 scores were significantly associated with the treatment type (p < 0.001) and that nationality was significantly predictive of the treatment type (p < 0.001).

Conclusion
In the setting of easy accessibility to treatment for Kuwaiti patients, biologics were prescribed by rheumatologists at a higher rate than for non-Kuwaitis. This may explain the lower disease activity and the lower rate of steroid use in Kuwaiti patients than non-Kuwaitis.

Key points

• Significant discrepancies in the rates of prescribing biologic therapies between KP and NKP in Kuwait were observed.
• Several treatment outcomes were significantly better in the KP group than in the NKP group even after adjustment of confounding factors.
• The poor access to biologic therapies was suggested to limit the effectiveness of RA treatments in the NKP group.
Indeterminate pronouns in Old English: a compositional semantic analysis
Authors: Beck Sigrid 
Published: October 2020

AbstractIndeterminate pronouns in Old English (expressions likehwa‘who/what’ andhwelc‘which’) permit several interpretations in addition to their use as interrogative pronouns, for example readings as universal or existential quantifiers. They combine with morphological prefixes (ge- ‘and, also’ anda- ‘always, ever’), which change the range of possible interpretations. Old English indeterminate pronouns are shown to contribute a crosslinguistically hitherto unattested pattern of available interpretations. In particular, bare indeterminate pronouns have a universal interpretation andge-indeterminate pronouns can be both universal and existential. This paper offers an alternative semantic analysis in the spirit of Hamblin (Found Lang 10:41–53, 1973) and Shimoyama (Nat Lang Semant 14:139–173, 2006). A compositional semantics is given for the pronouns and the prefixes, which derives the available readings. The paper ends with a proposal for compositional semantic change relating Old English indeterminate pronouns to their modern descendants.
Reducing the Toxicity of Long-Term Glucocorticoid Treatment in Large Vessel Vasculitis
Authors: Palmowski Andriko , Buttgereit Frank 
Published: October 2020

Abstract
Purpose
While glucocorticoids (GCs) are effective in large vessel vasculitis (LVV), they may cause serious adverse events (AEs), especially if taken for longer durations and at higher doses. Unfortunately, patients suffering from LVV often need long-term treatment with GCs; therefore, toxicity needs to be expected and countered.

Recent Findings
GCs remain the mainstay of therapy for both giant cell arteritis and Takayasu arteritis. In order to minimize their toxicity, the following strategies should be considered: GC tapering, administration of conventional synthetic (e.g., methotrexate) or biologic (e.g., tocilizumab) GC-sparing agents, as well as monitoring, prophylaxis, and treatment of GC-related AEs. Several drugs are currently under investigation to expand the armamentarium for the treatment of LVV.

Summary
GC treatment in LVV is effective but associated with toxicity. Strategies to minimize this toxicity should be applied when treating patients suffering from LVV.
Systems Engineering approach for the concept design of the Crystal Eye detector
Authors: Renno F. , Barbato F. , Barbarino G. , Marzullo D. , Guida R. , Papa S. 
Published: October 2020

AbstractMain targets of this activity research are the making and the optimization of new detectors by means of the Systems Engineering methods. With the observation of the gravitational wave event of August 17th, 2017 and then with those of the extragalactic neutrino of September 22nd, the Multimessenger Astrophysics era began. It is a new way of exploring the Universe, powered by globally coordinated observations of several experiments. So, new X and gamma rays’ detectors solutions are needed in order to provide competitive results in the energy range 10 keV–10 meV. Here is briefly described how the Systems Engineering can improve the development of the proposal of a new technique: The Crystal Eye, a wide field of view detector with a good spatial resolution obtained thanks to a high pixelation.
Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model
Authors: Nishino Koichiro , Takasawa Ken , Okamura Kohji , Arai Yoshikazu , Sekiya Asato , Akutsu Hidenori , Umezawa Akihiro 
Published: October 2020

AbstractThe use of human induced pluripotent stem cells (iPSCs), used as an alternative to human embryonic stem cells (ESCs), is a potential solution to challenges, such as immune rejection, and does not involve the ethical issues concerning the use of ESCs in regenerative medicine, thereby enabling developments in biological research. However, comparative analyses from previous studies have not indicated any specific feature that distinguishes iPSCs from ESCs. Therefore, in this study, we established a linear classification-based learning model to distinguish among ESCs, iPSCs, embryonal carcinoma cells (ECCs), and somatic cells on the basis of their DNA methylation profiles. The highest accuracy achieved by the learned models in identifying the cell type was 94.23%. In addition, the epigenetic signature of iPSCs, which is distinct from that of ESCs, was identified by component analysis of the learned models. The iPSC-specific regions with methylation fluctuations were abundant on chromosomes 7, 8, 12, and 22. The method developed in this study can be utilized with comprehensive data and widely applied to many aspects of molecular biology research.
Burnout und psychosoziale Arbeitsbedingungen in Berufsgruppen mit hohen kognitiven Anforderungen
Authors: Kersten Norbert , Formazin Maren , Müller Grit 
Published: October 2020

Zusammenfassung
Hintergrund
Burnout ist ein psychologisches Syndrom, das aufgrund seiner Konsequenzen sowohl für die Betroffenen selbst als auch für die Betriebe und die Gesellschaft als Ganzes von hoher Relevanz ist.

Fragestellung
Die Ausprägung von Burnout und sein Zusammenhang mit psychosozialen Arbeitsbedingungen werden in drei Berufsgruppen mit hohen kognitiven Anforderungen – Softwareentwickler/innen, Werbefachleute, Publizist/innen – im Vergleich zur Beschäftigtenpopulation in Deutschland untersucht.

Material und Methoden
Es werden Daten aus zwei Querschnittsstudien zusammengefasst (n = 6553). Die psychosozialen Arbeitsbedingungen wurden mit dem Copenhagen Psychosocial Questionnaire (COPSOQ), Burnout mit dem Oldenburger Burnout-Inventar (OLBI) erfasst. Um die Beziehung zwischen Arbeitsbedingungen und Burnout zu ermitteln, wurden Regressionsmodelle unter Berücksichtigung von möglichen Confoundern angepasst und zusätzlich Interaktionen zwischen Berufen und Arbeitsbedingungen ermittelt.

Ergebnisse
Die Burnout-Scores sind in den drei Berufsgruppen nicht generell höher als in der Vergleichsgruppe. Werbefachfrauen und Publizistinnen weisen höhere, gegenüber den Softwareentwicklerinnen und der weiblichen Beschäftigtenpopulation, jedoch nicht statistisch signifikante unterschiedliche Burnout-Werte auf. Bei den Männern weisen Softwareentwickler signifikant niedrigere Burnout-Werte als Werbefachmänner auf. Die drei Berufsgruppen haben ein niedrigeres Maß an Führungsqualität und Rollenklarheit sowie ein höheres Maß an quantitativen Anforderungen, aber auch an Entscheidungsspielraum und sozialer Unterstützung als die Beschäftigtenpopulation. Bei Männern und Frauen sind insbesondere hohe quantitative Anforderungen positiv mit Burnout assoziiert. Arbeitsplatzressourcen, z. B. Führungsqualität, hängen negativ mit Burnout zusammen.

Diskussion
Über den Durchschnittseffekt der gesamten Stichprobe hinaus wirken sich insbesondere quantitative Anforderungen, aber auch Führungsqualität und soziale Unterstützung in den drei Berufsgruppen in stärkerem Maße auf das Burnout-Level aus. Die Spezifik der Effekte in den drei Berufsgruppen impliziert, dass Arbeitsgestaltungsmaßnahmen für die jeweiligen Berufsgruppen sowohl allgemeine als auch spezifische Aspekte berücksichtigen sollten.
L’autorité de l’écrit pragmatique dans la société chrétienne éthiopienne (xve-xviiie siècle)
Authors: Wion Anaïs 
Published: October 2020

RésumésLe pouvoir royal chrétien éthiopien a produit, entre le xie et le milieu du xxe siècle, nombre de documents écrits témoignant de donations de terre et de transferts de privilèges accordés aux institutions religieuses et aux grands du royaume. Bien que seule émettrice d’actes écrits, l’autorité royale a manifesté peu d’intérêt pour le devenir de ces documents : elle ne les a pas conservés, ne les dotait d’aucune marque externe de validation et acceptait relativement facilement qu’ils soient modifiés. Ce paradoxe se résout après une étude approfondie des pratiques qui permirent la production, puis la conservation de cette documentation. Ainsi, le pouvoir royal mettait en place des comités ad hoc qui se déplaçaient dans les provinces afin d’y faire promulguer les actes, ou émettait ceux-ci depuis le camp royal pour les dépêcher ensuite vers les institutions concernées. La mise par écrit et l’archivage étaient délégués aux institutions religieuses, qu’elles soient bénéficiaires directes des actes ou qu’elles fonctionnent comme des centres administratifs régionaux. Il est encore difficile de percevoir des scansions chronologiques dans ces processus. Néanmoins, un changement radical s’opère à partir de la décennie 1720 : les personnes privées s’arrogent le droit de faire écrire en langue vernaculaire leurs transferts de droits. La stabilité de la société gondarienne et la professionnalisation des scribes dans les églises ont permis à ces derniers de devenir les notaires de leurs communautés tout en servant les intérêts de la petite noblesse. La bureaucratie éthiopienne échappe au monopole du pouvoir souverain pour servir la communauté des propriétaires fonciers.
L’historien entre aux archives: Comment l’historiographie russe d’avant 1917 a découvert l’État moscovite
Authors: Joukovskaia Anna , Akelev Evgenii 
Published: October 2020

RésumésL’article analyse les biais que l’archivage a introduits dans l’historiographie russe sur l’État de Moscou avant la révolution de 1917. Il commence par présenter les principales étapes de l’organisation des dépôts d’archives historiques depuis l’époque de Pierre le Grand. Pendant longtemps, la politique archivistique de l’État vis-à-vis des dépôts historiques se révèle à la fois passive et défiante : peu d’investissements sont faits dans la conservation et la description des fonds, qui demeurent d’un accès difficile pour les chercheurs. Marquée par les réformes libérales du règne d’Alexandre II, la seconde moitié du xixe siècle voit une nouvelle étape avec la création d’un important dépôt d’archives historiques, les archives du ministère de la Justice à Moscou (Mamju), et la naissance d’une république des lettres russe. C’est alors qu’émergent les hypothèses historiques fondamentales qui continuent, aujourd’hui encore, à façonner l’idée que nous nous faisons de l’État de Moscou des xvie-xviie siècles. Deux études de cas sont présentées : l’utilisation des cadastres anciens (piscovye knigi) en tant que source pour l’histoire économique et sociale, et la théorie des groupes sociaux (soslovija) de Vasilij Ključevskij. Ces exemples montrent comment la segmentation des fonds d’archives, l’état inégal de leur conservation, les ambitions de l’archivistique ainsi que la nature et le rythme de mise à disposition de nouveaux outils d’investigation produits par les archivistes influencent les programmes et les résultats de la recherche historique.
Dérogation générale et déclassification des archives contemporaines: Le cas d’Audin et des disparus de la Guerre d’indépendance algérienne
Authors: Thénault Sylvie 
Published: October 2020

RésumésComme des milliers de militants de l’indépendance algérienne, Maurice Audin a disparu à Alger en 1957, après son arrestation par les parachutistes. En France, son nom est devenu l’emblème de la dénonciation de la torture pendant la Guerre d’Algérie. Très engagé dans cette cause, Pierre Vidal-Naquet est ainsi devenu le tout premier historien de la torture et du système répressif à l’œuvre en Algérie. Officiellement, Audin s’est évadé, mais sa femme, Josette Audin, n’a cessé de demander la vérité et la reconnaissance de la responsabilité de l’État dans la disparition du jeune mathématicien. Après un long combat, Emmanuel Macron a fini par la reconnaître, le 13 septembre 2018, et a annoncé la création d’une dérogation générale pour accéder aux archives non encore ouvertes concernant tous les disparus de cette guerre. Cet article revient sur l’histoire de cette annonce et ses enjeux, selon quatre points de vue : l’identification et la localisation des archives potentiellement concernées ; les évolutions de l’historiographie ; les attentes des familles ; la nécessaire déclassification des archives, à la suite d’une procédure récente et très critiquée qui bloque l’accès aux archives contemporaines. Deux questions émergent alors. D’une part, comment les militants et les historiens ont-ils répondu au déséquilibre qui marque la cause des « disparus », entre Algériens dits « musulmans » à l’époque et Audin, militant communiste, universitaire, Français de nationalité ? D’autre part, du point de vue de l’accès aux archives en général, quels problèmes soulève l’annonce de cette dérogation générale ?
Platelet ice, the Southern Ocean's hidden ice: a review
Authors: Hoppmann Mario , Richter Maren E. , Smith Inga J. , Jendersie Stefan , Langhorne Patricia J. , Thomas David N. , Dieckmann Gerhard S. 
Published: October 2020

AbstractBasal melt of ice shelves is not only an important part of Antarctica's ice sheet mass budget, but it is also the origin of platelet ice, one of the most distinctive types of sea ice. In many coastal Antarctic regions, ice crystals form and grow in supercooled plumes of Ice Shelf Water. They usually rise towards the surface, becoming trapped under an ice shelf as marine ice or forming a semi-consolidated layer, known as the sub-ice platelet layer, below an overlying sea ice cover. In the latter, sea ice growth consolidates loose crystals to form incorporated platelet ice. These phenomena have numerous and profound impacts on the physical properties, biological processes and biogeochemical cycles associated with Antarctic fast ice: platelet ice contributes to sea ice mass balance and may indicate the extent of ice-shelf basal melting. It can also host a highly productive and uniquely adapted ecosystem. This paper clarifies the terminology and reviews platelet ice formation, observational methods as well as the geographical and seasonal occurrence of this ice type. The physical properties and ecological implications are presented in a way understandable for physicists and biologists alike, thereby providing the background for much needed interdisciplinary research on this topic.