bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitale Plattformen: Strategien für KMU
Authors: Bender Benedict , Habib Natalie , Gronau Norbert 
Published: October 2020

ZusammenfassungObwohl digitale Plattformen vornehmlich von Großunternehmen betrieben werden, bieten sie klein- und mittelständischen Unternehmen (KMU) Potenziale zur Verbreitung innovativer Technologien und für den Ausbau ihres Geschäftsmodells. Für die Umsetzung digitaler Plattformen stehen Unternehmen mehrere Strategien zur Verfügung. Der Beitrag vergleicht und bewertet grundlegende Strategien am Beispiel eines Maschinenbauunternehmens. Die Ergebnisse dienen als Grundlage für die Entscheidungsfindung von KMU.
Introducing the principles of Enhanced Recovery to a fractured neck of femur pathway 5 years results and experience
Authors: Wainwright Thomas , Immins Tikki , Middleton Robert 
Published: October 2020

Introduction

There is great potential for the principles of Enhanced Recovery to be successfully applied to fractured neck of femur (FNOF) pathways and help to improve clinical outcomes.

Aim

To present the 5-year results and experience from Poole Hospital of applying the principles of Enhanced Recovery to FNOF patients.

Method

A mixed-methods sequential explanatory design (QUAN emphasised) that consists of quantitative followed by qualitative data collected to evaluate the project. Quantitative outcome data were extracted from Hospital Episode Statistics for 2008/09 to 2013/14 and analysed using a relative risk methodology. Relative Risk is the ratio of the observed number of outcomes to the expected number of outcomes and is case-mix adjusted. The NHS England average is calculated and 95% confidence intervals are applied to determine statistical difference from unit performance to the equivalent case-mix. Qualitative data were collected via staff interviews.

Results

A mean length of stay (LOS) of 12.3 days, a mortality rate of 5.7%, a 28-day re-admission rate of 10.2%, and a discharge home rate of 55% achieved in the last year of the project are lower than expected for hospital case-mix
Staff interviews highlighted that key factors for success were:
1.Collaborative practice across all teams
2.Input from the Department of Medicine for the Elderly
3.Changing the pre-operative mindset whereby instead of having to prove patients are fit for surgery, they are assessed as fit for surgery unless proven otherwise.

Conclusions

Enhanced Recovery can be successfully applied to FNOF patients in order to improve patient outcomes. However, implementation may be more challenging and take longer than for elective orthopaedic procedures.
THE IMPORTANCE OF LABORAL REST IN MAINTENANCE OF WORKER'S MENTAL HEALTH: A SYSTEMATIC REVIEW
Authors: Costa Aline Mesquita da , Maranhão Thércia Lucena Grangeiro 
Published: October 2020

Abstract: This article aims to make a systematic review on the Importance of Work Rest in the Maintenance of Metal Worker's Health, it was observed that the intensification of the working day can be harmful to mental health and consequently its quality of life. The guiding question is: what is the importance of homes for maintaining workers' mental health? The research was carried out through the methodology of systematic review and aims to: Study the relationship between the intervals to improve the quality of life of the worker; Analyze factors that contribute to the maintenance of the worker's mental health; Understand the damage that exhaustive periods of work can bring to workers' lives. Key words: Workday, rest, workload, quality of life, worker health, labor legislation.
Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration
Authors: Breus Oksana , Dickmeis Thomas 
Published: October 2020

Abstract
Important roles for reactive oxygen species (ROS) and redox signaling in embryonic development and regenerative processes are increasingly recognized. However, it is difficult to obtain information on spatiotemporal dynamics of ROS production and signaling in vivo. The zebrafish is an excellent model for in vivo bioimaging and possesses a remarkable regenerative capacity upon tissue injury. Here, we review data obtained in this model system with genetically encoded redox-sensors targeting H2O2 and glutathione redox potential. We describe how such observations have prompted insight into regulation and downstream effects of redox alterations during tissue differentiation, morphogenesis and regeneration. We also discuss the properties of the different sensors and their consequences for the interpretation of in vivo imaging results. Finally, we highlight open questions and additional research fields that may benefit from further application of such sensor systems in zebrafish models of development, regeneration and disease.
Cross-cultural interpretation of filmic metaphors: A think-aloud experiment
Authors: Bort-Mir Lorena , Bolognesi Marianna , Ghaffaryan Susan 
Published: October 2020

Abstract
The purpose of this study is to investigate how viewers who speak different languages interpret cinematographic metaphors in a filmic advertisement. The study is organized in three parts: First, we offer a theoretical model that predicts the offline mental mechanisms that occur while people interpret filmic metaphors, based on an existing model of visual metaphor processing. Second, we evaluate the model in a think-aloud retrospective task. A TV-commercial is projected individually to 30 Spanish, 30 American, and 30 Persian participants, who are then asked to verbalize their thoughts. The commercial was previously segmented, analyzed using FILMIP (Filmic Metaphor Identification Procedure), and marked for metaphoricity by two independent analysts. The collected data is then evaluated in two formal content analyses. In the first one, two independent coders classified all the clauses used by the 90 participants in relation to the steps outlined in the theoretical model. In the second analysis, those clauses in which the participants were constructing their metaphorical interpretation of the filmic advertisement were annotated for the type of metaphor they constructed. The general results show that: (1) some mental processes seem to be more prominent in some cultures and not in others, and (2) genre-related knowledge plays a crucial role in constructing filmic metaphors in certain cultures and not in others. With this study, we theoretically formalize and empirically test the types of operations reflected in the language that viewers use to describe how they interpret filmic metaphors, thus advancing the current theory and methods on filmic metaphor interpretation from cognitive, semiotic, and cross-cultural perspectives.
Investigation of Microorganisms Deteriorating Ancient Ola Leaf Manuscripts
Authors: Kim Young-Hee , Choi Kyoung-Hwa , Hong Jin-Young , Lee Jeung-Min , Kim Soo-Ji , Jo Chang-Wook , Jeong So Young 
Published: October 2020

Abstract
Ola leaf manuscripts from Sri Lanka date back to several centuries. While they have been well preserved over the last century, their condition has worsened in recent years when black dots caused by microorganisms started occurring on their surface. In this study, the current state of preservation and the factors causing deterioration are examined using microscopy techniques. Microscopic images clearly show that the manuscripts are contaminated by microorganisms which penetrated deeply into the carrier material, destroying the internal structure. A Penicillium griseofulvum strain was recognized as the most active microorganism in xylan degradation. Sri Lanka’s climate provides favorable conditions for the growth of these fungi. Therefore, it is suggested that temperature and humidity of the archival space should be better controlled in order to ensure the Ola leaf manuscripts’ long-term preservation.
Porphyry, Steuco and the Journey of Oracles between

Symphony and Conflict
Authors: Tissi Lucia 
Published: October 2020

Abstract
In this paper I explore the reasons why oracular texts of the past are considered to be useful to demonstrate a cultural symphony and how the perception of them changed in space and time. Moreover, I investigate how oracles worked as means of unity, agreement and cohesion in a society risking fragmentation and division. Specifically, I analyse Porphyry’s oracular collection De philosophia ex oraculis haurienda (transmitted indirectly) and Agostino Steuco’s major work, De perennia philosophia, published in 1540. Despite living in different historical eras, Porphyry and Steuco—I argue—seem to look for a kind of cultural symphony and to return to oracular wisdom as a response to a perceived and real threat (Christian religion for the first, Protestant Reform for the second). Their responses to the threat show various points of contact: against the risk of oblivion, they re-use and recover pre-fabricated sources of knowledge drawn from the past or the present, in order to address the challenges of their time with the aid of an established, “perennial” theological tradition. While the response provided by Porphyry against threats can be regarded as an elitist and exclusionary project, Steuco proposes, in his symphonic and propagandistic system, a real reductio ad unum (una religio, una scientia, unus Deus).
Mocking Parades and the Place of Pagan Statuary in Late Antique Alexandria
Authors: Stutz Jonathan 
Published: October 2020

Abstract
With the present paper I would like to discuss a particular form of procession which we may term mocking parades, a collective ritual aimed at ridiculing cultic objects from competing religious communities. The cases presented here are contextualized within incidents of pagan/Christian violence in Alexandria between the 4th and 5th centuries, entailing in one case the destruction of the Serapeum and in another the pillaging of the Isis shrine at Menouthis on the outskirts of Alexandria. As the literary accounts on these events suggest, such collective forms of mockery played an important role in the context of mob violence in general and of violence against sacred objects in particular. However, while historiographical and hagiographical sources from the period suggest that pagan statues underwent systematic destruction and mutilation, we can infer from the archaeological evidence a vast range of uses and re-adaptation of pagan statuary in the urban space, assuming among other functions that of decorating public spaces. I would like to build on the thesis that the parading of sacred images played a prominent role in the discourse on the value of pagan statuary in the public space. On the one hand, the statues carried through the streets became themselves objects of mockery and violence, involving the population of the city in a collective ritual of exorcism. On the other hand, the images paraded in the mocking parades could also become a means through which the urban space could become subject to new interpretations. Entering in visual contact with the still visible vestiges of the pagan past, with the temples and the statuary of the city, the “image of the city” became affected itself by the images paraded through the streets, as though to remind the inhabitants that the still-visible elements of Alexandria’s pagan topography now stood as defeated witnesses to Christianity’s victory.
Rom, der Tomus Leonis und das 6. Ökumenische Konzil (680/681)
Authors: Ohme Heinz 
Published: October 2020

Abstract
This article analyses the dyothelete and dyenergist Christology in the following texts: the Horos and the Logos Prosphonetikos of the Sixth Ecumenical Council (680/681), the epistle of pope Agatho, which became officially authorized as a teaching text, and the letter of the roman synod of the 125 bishops. The results of this analysis are compared with the Christology of the Lateran Council of 649 and the theology of Maximus the Confessor, upon which it is based. The council claims to define things in a way that complements and concludes the results of the council of Chalcedon (451) by designating the will and the capacity to act as properties of the ontological categories of φύσις/οὐσία and thus formulating the doctrine of the double willing and acting of Christ. In fact, the council draws on text of the Acts of the Council of Chalcedon but changes the order of priority of the texts (which were made authoritative in Chalcedon) of Cyril of Alexandria and Pope Leo I. so that the Tomus Leonis, which contains pointed statements that were controversial both during and after Chalcedon, becomes the hermeneutical key to the doctrine of two natures. Both natures become subjects of willing and acting and the meaning of the ὑπόστασις remains underdeveloped in comparison with that of φύσις and πρόσωπον. Thus the council neither comes to terms with the development of Leo’s thought nor with the Christology of the Lateran Councils nor with the Christology of Maximus. In fact, fundamental distinctions in the meaning of θέλημα and ἐνέργεια as well as of φύσις and ὑπόστασις have not been taken into consideration by the council in 681. Instead, the council remains with the initial ontological concepts due to its recourse to an ontologized Tomus Leonis. Additionally, it is worth mentioning that this is the first ecumenical council to establish the primacy of and infallibility of the Roman Pope. The final concern of this article is to ask how this development could come about.
Vitamins C and E Associated With Cryotherapy in the Recovery of the Inflammatory Response After Resistance Exercise: A Randomized Clinical Trial
Authors: de Brito Edineia , Teixeira André de Oliveira , Righi Natiele Camponogara , Paulitcth Felipe da Silva , da Silva Antonio Marcos Vargas , Signori Luis Ulisses 
Published: October 2020

Abstract
de Brito, E, Teixeira, AdO, Righi, NC, Paulitcth, FdS, da Silva, AMV, and Signori, LU. Vitamins C and E associated with cryotherapy in the recovery of the inflammatory response after resistance exercise: A randomized clinical trial. J Strength Cond Res 36(1): 135–141, 2022—The objective of this research was to compare the effects of cryotherapy associated with vitamins (C and E) on the recovery of the inflammatory response from the resistance exercise (RE) session of untrained volunteers. Fourteen subjects (26.2 ± 5 years old, 25.8 ± 3 kg·m−2) underwent 4 sessions of RE with different forms of recovery. The RE consisted of 4 sets of 10 maximal repetitions for each exercise (extensor bench, squat, and leg press). The recoveries were randomized and comprised the passive (control), with vitamins C (1 g) and E (800 UI) supplementation 40 minutes before exercise, with cryotherapy (immersion in water 15° C for 10 minutes), and the association (vitamins and cryotherapy). Hemogram, inflammatory markers (C-reactive protein and creatine kinase [CK]), and parameters of oxidative stress (lipid peroxidation [LPO] and antioxidant capacity against radical peroxyl) were evaluated before (baseline) and after (0, 30, and 120 minutes) the RE sessions. Muscle pain (primary outcome) was evaluated 24 hours after exercise. C-reactive protein (p = 0.010) and LPO (p < 0.001) increased (120 minutes) only in passive recovery. Recovery with cryotherapy (30 minutes), with vitamins and the association (0 and 30 minutes) delayed increases in CK (p < 0.001). Antioxidant capacity against radical peroxyl increased (30 minutes) only in recovery with the association (p < 0.011). The pain decreased in the recoveries with cryotherapy and association (p < 0.001). The association of vitamins (C and E) with cryotherapy attenuated the inflammatory response and pain, favoring recovery after an acute RE session.
Stress–Strain Relationship Model and Gray Entropy Analysis of Recycled Coarse Aggregate Concrete
Authors: Li Qiong , Qiao Hongxia , Guo Jian , Li Yuanke 
Published: October 2020

Abstract
In this research, the effects of recycled coarse aggregate (RCA) gradation (5–10 mm, 5–16 mm, 5–20 mm, and 5–31.5 mm), RCA content (30 %, 50 %, and 70 %), fly ash content (10 %, 20 %, and 30%) and water–binder ratio (0.35, 0.4, and 0.45) on the stress–strain constitutive relationship of recycled aggregate concrete (RAC) were analyzed. For this purpose, 45 prism specimens were designed, and then it was obtained by gray relational entropy analysis that the water–binder ratio and RCA content have a considerable influence on RAC’s mechanical and energy absorption properties. A mathematical expression for the stress–strain constitutive relationship of the RAC concerning the four aforementioned factors was developed through experimental investigation and regression analysis. The proposed model is compared with the experimental date, and the result has a good fit.
Strategic and Non-Strategic Semantic Expectations Hierarchically Modulate Neural Processing
Authors: Vidal-Gran Consuelo , Sokoliuk Rodika , Bowman Howard , Cruse Damian 
Published: October 2020

AbstractPerception is facilitated by a hierarchy of expectations generated from context and prior knowledge. In auditory processing, violations of local (within-trial) expectations elicit a mismatch negativity (MMN), while violations of global (across-trial) expectations elicit a later positive component (P300). This result is taken as evidence of prediction errors ascending through the expectation hierarchy. However, in language comprehension, there is no evidence that violations of semantic expectations across local-global levels similarly elicit a sequence of hierarchical error signals, thus drawing into question the putative link between event-related potentials (ERPs) and prediction errors. We investigated the neural basis of such hierarchical expectations of semantics in a word-pair priming paradigm. By manipulating the overall proportion of related or unrelated word-pairs across the task, we created two global contexts that differentially encouraged strategic use of primes. Across two experiments, we replicated behavioral evidence of greater priming in the high validity context, reflecting strategic expectations of upcoming targets based on “global” context. In our preregistered EEG analyses, we observed a “local” prediction error ERP effect (i.e., semantic priming) ∼250 ms post-target, which, in exploratory analyses, was followed 100 ms later by a signal that interacted with the global context. However, the later effect behaved in an apredictive manner, i.e., was most extreme for fulfilled expectations, rather than violations. Our results are consistent with interpretations of early ERPs as reflections of prediction error and later ERPs as processes related to conscious access and in support of task demands.
Immune checkpoint inhibitor therapy for ACTH-secreting pituitary carcinoma: a new emerging treatment?
Authors: Sol Bastiaan , de Filette Jeroen M K , Awada Gil , Raeymaeckers Steven , Aspeslagh Sandrine , Andreescu C E , Neyns Bart , Velkeniers Brigitte 
Published: October 2020

Background
Pituitary carcinomas are rare but aggressive and require maximally coordinated multimodal therapies. For refractory tumors, unresponsive to temozolomide (TMZ), therapeutic options are limited. Immune checkpoint inhibitors (ICI) may be considered for treatment as illustrated in the present case report.

Case
We report a patient with ACTH-secreting pituitary carcinoma, progressive after multiple lines of therapy including chemotherapy with TMZ, who demonstrated disease stabilization by a combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) ICI therapy.

Discussion
Management of pituitary carcinoma beyond TMZ remains ill-defined and relies on case reports. TMZ creates, due to hypermutation, more immunogenic tumors and subsequently potential candidates for ICI therapy. This case report adds support to the possible role of ICI in the treatment of pituitary carcinoma.

Conclusion
ICI therapy could be a promising treatment option for pituitary carcinoma, considering the mechanisms of TMZ-induced hypermutation with increased immunogenicity, pituitary expression of CTLA-4 and PD-L1, and the frequent occurrence of hypophysitis as a side effect of ICI therapy.
Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study
Authors: Leung Alexander A , Pasieka Janice L , Hyrcza Martin D , Pacaud Danièle , Dong Yuan , Boyd Jessica M , Sadrzadeh Hossein , Kline Gregory A 
Published: October 2020

Objective
Despite the significant morbidity and mortality associated with pheochromocytoma and paraganglioma, little is known about their epidemiology. The primary objective was to determine the incidence of pheochromocytoma and paraganglioma in an ethnically diverse population. A secondary objective was to develop and validate algorithms for case detection using laboratory and administrative data.

Design
Population-based cohort study in Alberta, Canada from 2012 to 2019.

Methods
Patients with pheochromocytoma or paraganglioma were identified using linked administrative databases and clinical records. Annual incidence rates per 100 000 people were calculated and stratified according to age and sex. Algorithms to identify pheochromocytoma and paraganglioma, based on laboratory and administrative data, were evaluated.

Results
A total of 239 patients with pheochromocytoma or paraganglioma (collectively with 251 tumors) were identified from a population of 5 196 368 people over a period of 7 years. The overall incidence of pheochromocytoma or paraganglioma was 0.66 cases per 100 000 people per year. The frequency of pheochromocytoma and paraganglioma increased with age and was highest in individuals aged 60–79 years (8.85 and 14.68 cases per 100 000 people per year for males and females, respectively). An algorithm based on laboratory data (metanephrine >two-fold or normetanephrine >three-fold higher than the upper limit of normal) closely approximated the true frequency of pheochromocytoma and paraganglioma with an estimated incidence of 0.54 cases per 100 000 people per year.

Conslusion
The incidence of pheochromocytoma and paraganglioma in an unselected population of western Canada was unexpectedly higher than rates reported from other areas of the world.
Perspective: Linkage Maps, Communities of Geneticists, and Genome Databases
Authors: Botstein David 
Published: October 2020

Abstract
The Thomas Hunt Morgan Medal recognizes lifetime contributions to the field of genetics. The 2020 recipient is David Botstein of Calico Labs and Princeton University, recognizing his multiple contributions to genetics, including the collaborative development of methods for defining genetic pathways, mapping genomes, and analyzing gene expression.