bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Epidemiological Assessment of Malaria Cases in Udalguri District of Assam with Special Emphasis on Intensified Malaria Control Project (2008 to 2017)
Authors: Ahmed Rahim Ali , Kumar Avdhesh , Swargiary Ananta , Barman Keshab , Begum Afluza 
Published: September 2020

Abstract
Udalguri district of Assam, North East India is endemic to malaria. There is a high prevalence of vector-borne diseases in this part of Assam, including malaria. In the present study, an epidemiological assessment was carried out for the period of 2008 to 2017 to understand the prevalence of malaria in the district in accordance with Intensified Malaria Control Project, Government of India. The databases for the study were collected from district NVBDCP unit under the establishment of Joint Director of Health Services, Udalguri. All the data were analyzed using Microsoft excel in statistical method (P≤0.05). The study found that the annual parasite index (API) drastically declined from 14.54 to 1.24 cases per 1000 population during 2008 to 2017. Among all the positive cases, two plasmodium species, Plasmodium falciparum and Plasmodium vivax were found to be the major species followed by some mixed infection. The malaria cases caused by P. vivax were more (68.5%) than P. falciparum (31.5%). The disease prevalence by P. vivax cases are significantly decreased from 12.06 cases per 1000 population in 2008 to 0.28 cases per 1000 population in 2017. Similarly the P. falciparum cases also declined from 3.94 cases per 1000 population in 2008 to 0.96 cases per 1000 population in 2017. The decrease of disease prevalence of malaria cases may be because of effective implementation of vector and disease control strategies. The transmission starts from April onwards and reach peak during the month of June & July. LLINs were found to be effective strategies to control & prevent the disease transmission.
A Review on COVID-19 Forecasting Models
Authors: Rahimi Iman , Chen Fang , Gandomi Amir H. 
Published: September 2020

Abstract
The Novel coronavirus (COVID-19) has distributed to more than 200 territory worldwide leading to about 24 million confirmed cases as of August 25, 2020. Several models have been released that forecast the outbreak globally. This work presents a review of the most important forecasting models against COVID-19 and shows a short analysis of each one. The work presented in this study possesses two parts. A detailed scientometric analysis was done in the first section that provides an influential tool for describing bibliometric analyses. The analysis was performed on data corresponding to COVID-19 using the Scopus and Web of Science databases. For analysis, keywords and subject areas were addressed while classification of forecasting models, criteria evaluation and comparison of solution approaches were done in the second section of the work. Conclusion and discussion are provided as the final sections of this study.
Psychometric properties of Brief-COPE inventory among nurses
Authors: Rahman Hanif Abdul , Issa Wegdan Bani , Naing Lin 
Published: September 2020

Abstract
Objective: Coping with persistent demands in modern healthcare and facing new challenges such as the COVID-19 pandemic, is increasingly necessary among nurses. Brief-COPE inventory is widely used to assess coping, however, validation evidence is absent and previous results were inconsistent. This study aimed to validate psychometric properties of Brief-COPE inventory to ensure culturally appropriate usage. Methods: Preliminary validation study on 423 female nurses from the United Arab Emirates. Confirmatory factor analysis (CFA) with maximum likelihood estimation was computed to test four different previous models. Exploratory factor analysis (EFA) protocol was used to determine underlying domain structure of Brief-COPE in this population.Results: The four previous models on CFA had inadequate fit indexes. Two-factor (22-items) second-order model that explained 37.0% of the total variance with Cronbach’s alpha at 0.81 and 0.88, respectively, was suggested. Conclusion: This validation of Brief-COPE is timely considering nurses enduring different types of stressors in addition to the COVID-19 pandemic situation. In addition, cultural diversity need to be considered in coping research. Re-assessment of this exploratory structure is necessary to ensure accurate measurement of coping strategies.
COVID19 Infection in A Patient Undergoing Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH) with Ravulizumab
Authors: Shikdar Sufana , Borogovac Azra , Mohamad Elabdallah , Khawandanah Mohamad 
Published: September 2020

Abstract
Background: In the recent COVID19 pandemic, patients with hematological malignancies were considered high risk for severe disease. Limited data is available regarding course of COVID19 infection in this subgroup. Case Presentation: We describe a case of 32-year‐old man with paroxysmal nocturnal hemoglobinuria (PNH) undergoing treatment with ravulizumab (Ultomiris) who presented with COVID19 infection. He experienced only mild symptoms and had a rapid recovery from COVID19 infection. Conclusion: This case may demonstrate the beneficial effects of ravulizumab on complement mediated inflammatory damage linked with COVID19 infection especially in PNH patients.
Implementing Telemedicine for the Management of Benign Urologic Conditions: A Single Centre Experience in Italy
Authors: Checcucci Enrico , De Luca Stefano , Alessio Paolo , Verri Paolo , Granato Stefano , De Cillis Sabrina , Amparore Daniele , Sica Michele , Piramide Federico , Piana Alberto , Volpi Gabriele , Manfredi Matteo , Balestra Gabriella , Autorino Riccardo , Fiori Cristian , Porpiglia Francesco 
Published: September 2020

Abstract
Purpose: to assess the use of telemedicine with phone-call visits as practical tool to follow-up with patients affected by urological benign diseases, whose clinic visits had been cancelled during the acute phase of the COVID-19 pandemic. Methods: patients were contacted via phone-call and a specific questionnaire was administered to evaluate the health status of these patients, and to identify those who needed an “in-person” ambulatory visit due to the worsening of their condition. Secondarily, the patients’ perception of a potential shift towards a "telehealth" approach to the management of their condition and to indirectly evaluate their desire to return to “in-person” clinic visits. Results: 607 were contacted by phone-call. 87.5% (531/607) of the cases showed stability of the symptoms so no clinic in-person or emergency visits were needed. 81.5% (495/607) of patients were more concerned about the risk of contagion than their urological condition. The median score for phone visit comprehensibility and ease of communication of exams was 5/5; whilst patients’ perception of phone visits’ usefulness was scored 4/5. 53% (322/607) of the interviewees didn’t own the basic supports required to be able to perform a real telemedicine consult according to the required standards. Conclusion: Telemedicine approach limits the number of unnecessary accesses to medical facilities and represent an important tool for the limitation of the risk of transmission of infectious diseases, such as COVID-19. However, infrastructures, health workers and patients should reach out to a computerization process in order to allow a wider diffusion of more advanced forms of telemedicine, such as televisit.
Benefits and Barriers Associated with Intention to Participate in Injury Prevention Programs in ROTC Cadets
Authors: Gabriel Emily , Powden Cameron 
Published: September 2020

Abstract
Background: There is a lack of participation in Exercise-Related Injury Prevention Programs (ERIPPs) within Reserve Officer Training Corps (ROTC) which limits the effectiveness. Identification of factors which may influence participation in ERIPPs within ROTC cadets is an important first step in improving adoption and adherence rates. Therefore, the purpose of the study was to identify factors associated with intention to participate in an ERIPP within ROTC cadets. Methods: The study design was cross-sectional where a paper survey was distributed in spring 2019. Twenty-eight (M/F=23/5; Age=20.68±2.02years; Height=175.78±8.95cm; Mass=75.30±11.10kg) ROTC cadets volunteered to participate in this study. Participants completed the Health Belief Model Scale (HBMS) and Theory of Planned Behavior Scale (TPBS) to assess attitudes towards participation in ERIPPs. A backwards multiple linear regression was used to determine if associations between attitudes towards ERIPP participation and intention to participate existed. Partial eta squared was calculated for each significant variable to determine the strength of the association and alpha was set at P≤0.05 for all analyses.Results: Perceived benefits (B=4.364, ƞ2=0.68, p<0.001) had a positive and large association with intention to participate while perceived barriers (B=-2.43, ƞ2=0.40, p<0.001) had a negative and large association with intention to participate. There were no other statistically significant associations (p>0.05).Conclusion: Perceived benefits and barriers were significantly associated with intention to participate in ERIPPs within ROTC cadets. Implementation strategies for ERIPPs may need to focus on the benefits and barriers of participating in an ERIPP to increase adoption and adherence.
The role of health determinants in the influenza vaccination uptake among older adults (65+): a scope review
Authors: Roller-Wirnsberger Regina , Lindner Sonja , Kolosovski Lea , Platzer Elisabeth , Dovjak Peter , Flick Holger , Tziraki Chariklia , Illario Maddalena 
Published: September 2020

Abstract
Background: Although the burden of influenza infection is the highest in older adults, vaccination coverage remains low, despite this age group being more vulnerable than others. Aims: Given the current pandemic of SARS-CoV-2, it was the aim of this scope review to update knowledge on factors affecting seasonal influenza vaccine uptake among older adults in order to strengthen prevention approaches in the context of an overall burden of infectious diseases.Methods: We searched bibliographic databases from 2012 to 2019. All studies reviewed one or more social determinant of health listed by WHO, or factors affecting the decision-making process whether to accept influenza vaccine or not.Results: Overall, 44 studies were included, 41 determinants were extracted and summarized into six categories. Older age and constitutional factors including multiple chronic diseases as well as preventive lifestyle and frequent routine healthcare utilization positively affected vaccination uptake (VU). Living and working conditions are also researched determinants of influenza vaccine uptake. A small number of studies explored the role of social inclusion and system-based interventions. Discussion and Conclusions: This scope review provides a comprehensive overview on factors affecting seasonal influenza vaccination uptake among older citizens. The review also clearly shows gaps for evidence on system-based level or political strategies to improve vaccination uptake.
Factors Impacting Customer Attitude toward Buying Halal Cosmetics in Jabodetabek
Authors: Clarita Ni Made Adelia , Zimbalist Shannon Baladewa , Setiowati Rini 
Published: September 2020

The research aimed to analyze the relationship between religiosity, product involvement, customers’ knowledge toward customers’ attitudes on halal cosmetics, and the relationship between customers’ attitudes on halal cosmetics towards customers’ intention to buy them. The research used a self – administrated questionnaire with close-ended questions. The questionnaire was distributed as pretest to 30 respondents offline. Furthermore, the researchers received answers from 302 respondents out of 350 that were distributed. To assess the relationship between knowledge, involvement, and religiosity, a structural equation modeling technique was used. Data were analyzed using Smart PLS software to test validity and reliability. The findings its show that there is a positive relationship between knowledge, religiosity, and product involvement towards costumers’ attitudes of halal cosmetics on Indonesian Muslim women. Moreover, the results indicate that Muslim women in Indonesia have more positive attitudes and intentions towards halal cosmetic products. The results of the research give implications to the firm in competing for the general and international brands for the halal cosmetic industry.
Optimum Portfolio Analysis of Black-Litterman Model in The Indonesian Stock Exchange on Consumer Goods Industrial Sector
Authors: Pudjiani Meilina , Syaukat Yusman , Irawan Tony 
Published: September 2020

The aim of the research was to identify the allocation of optimum portfolio formation in consumer goods sector at Indonesian Stock Exchange from 2014 to 2018 by using Black-Litterman model. This quantitative research used secondary data on stock prices of the consumer goods sector on the Indonesian Stock Exchange from January 2014 to December 2018 which was obtained from Yahoo Finance and the Indonesia Stock Exchange. Four stocks formed the optimum portfolio of consumer goods sector identified by using Black-Litterman model. Those are stocks of PT Indofood CBP Sukses Makmur Tbk, PT Kimia Farma Tbk, PT Indofarma Tbk, PT Indofarma Tbk, and PT HM Sampoerna Tbk. The results show that stock with the biggest proportion was ICBP’s with proportion of 68,5379%. Meanwhile the smallest proportion was INAF’s, which is 3,0277%. The mean return was calculated from this proportion, resulting in 3,678% while the risk value was 1,471%.
Novel Therapeutic Approaches and Treatment Targets for Psoriatic Arthritis
Authors: Benfaremo Devis , Paci Valentino , Luchetti Michele Maria , Gabrielli Armando 
Published: September 2020

Background:
Psoriatic Arthritis (PsA) is the most common extracutaneous manifestation of
psoriasis. This chronic inflammatory arthritis is burdened with significant morbidity, leading to irreversible
joint damage and disability. In recent years, a deeper understating of its pathogenesis has led
to the development of several new drugs targeting different pathways.

Objectives:
This review aims to highlight the clinical efficacy and safety of the novel agents that have
become recently available for the treatment of PsA, as well as new promising therapeutic targets that
are being evaluated in clinical trials.

Methods:
For the purpose of this narrative review, we searched in the MEDLINE and ClinicalTrials.
gov databases.

Results:
After the introduction of the first biological drugs targeting Tumor Necrosis Factor (TNF),
several other drugs with different targets have been developed, including anti-Interleukin (IL)
12/23p40, anti-IL17, and, more recently, anti-IL23p19 agents.

Conclusions:
Data supporting the efficacy of different agents in the major domains of PsA, as well as
their safety issues, are summarized here. Finally, the current pipeline, including several novel nonbiological
small molecules, such as Janus kinase (JAK) inhibitors, that are currently being evaluated in
clinical trials are also presented.

Discussion:
The availability of newer therapeutic agents has substantially changed the treatment strategy
for PsA. In the future, a personalized treatment approach will probably achieve better control of
disease manifestations.
Biologically Active Antimicrobial Compounds from Marine Microorganisms (2005-2019)
Authors: Muddukrishnaiah Krishna , Akilandeswari K. , Prasad Sunnapu , Shilpa V.P. 
Published: September 2020

Introduction:
The increase in contagious diseases like nosocomial infections, urinary tract infections, and meningitis has led to the emergence of antimicrobial resistance urgently needs new antimicrobial medication with new modes of
action. Some of the antibiotics present in the market have been obtained from terrestrial plants, or extracted semisynthetically from materials which can be fermented.

Methods:
Marine microorganisms account for approximately 80% of sea biomass and they are essential for the survival and
well-being of aquatic habitats owing to their indispensable contribution to biogeochemical cycles and biological processes.
In marine ecosystems, microorganisms live as microbial communities in seawater, where symbiotic relationships are
formed, and their ecological functions are fulfilled.

Results:
Marine microorganisms remain the largest, most diverse and most exciting source of structurally and functionally complex antimicrobial agents. They are extremely involved in their structure and functions. Enormous biological wealth
lies in marine habitats. These microorganisms are potential sources of novel antimicrobial compounds to combat the most
infectious diseases like nosocomial infections, urinary tract infections.

Conclusion:
This study deals with biologically active antimicrobial compounds taken from marine microorganism source
which was reported between the years 2005 and 2019. This review highlights their chemical groups, their bioactivities and
sources. Marine microorganism exploitation techniques have also been reported by the authors.
In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands
Authors: Cabeza Marisa , Bautista Lucero , Bratoeff Eugene , Soriano Juan , Heuze Yvonne 
Published: September 2020

Introduction:
5α-reductase inhibitors have been proven useful for the treatment of prostate
diseases, which can be due to the unregulated activity of 5α-reductase enzyme. This study was focused
on determining the activity of four different derivatives of 17β-phenyl carbamoyl-androst-4-en-3-one
1–4 as inhibitors of 5α-reductase (5RD5A), to improve the effects of current drugs.

Methods:
In vitro effect of compounds 1-4 on the activity of the human prostate enzyme, 5α-reductase,
was determined by measuring IC50 values, the concentration of a compound that inhibits the activity of
5RD5A2 by 50%. In vivo, the pharmacological effects of compounds 1-4 were identified in a hamster
model of prostate hypertrophy.

Results:
The steroidal 17β-carboxamides 1, 3, and 4 (IC50 = 5±0.5, 0.112±0.045, 0.167±0.056 nM) significantly
inhibited the in vitro activity of the 5RD5A2 enzyme with higher potency than finasteride,
which is a drug known as a specific 5RD5A2 inhibitor (IC50 = 8.5±0.3 nM). Compounds 1, 3, and 4
were more potent than finasteride to decrease the size of hamster flank organs in castrated animals
treated with testosterone. Also, compounds 1-4 were more effective than finasteride itself to reduce the
weight of the prostate in the hamster model, without producing toxicological effects during the six days
of treatment.

Conclusion:
In conclusion, the steroidal 17 β-carboxamides 1-4 were suitable inhibitors of human
5RD5A2 activity, in addition to being able to reduce prostate weight without causing toxicity. These
steroids could, therefore, have promising therapeutic potential for the treatment of benign prostatic hyperplasia.
Protective Effect of Resveratrol against Glioblastoma: A Review
Authors: Ashrafizadeh Milad , Mohammadinejad Reza , Farkhondeh Tahereh , Samarghandian Saeed 
Published: September 2020

Background:
One of the most common tumors of the central nervous system is Glioblastoma (GBM).

Objective:
There is not still an appropriate cure for this malignant tumor. Plant-derived natural products have
demonstrated great potential in cancer therapy, and Resveratrol (Res) is among them. Therefore, the current study
focused on the protective effect of resveratrol against glioblastoma and its underlying mechanism.

Methods:
PubMed, Medline, Scopus, Web of Science, and Google Scholar were searched by using the following keywords: Resveratrol,
Glioblastoma, Brain tumor, Cancer therapy, Medicinal herbs to July 2020.

Results:
Res is a non-flavonoid polyphenol responsible for the protection of plants against pathogen attacks. Res
has multiple pharmacological effects, including antioxidant, anti-inflammatory, anti-diabetic, and anti-tumor. Res
is capable of penetration into the blood-brain barrier, making it suitable for brain tumor therapy. Besides, Res
targets various molecular signaling pathways in cancer therapy.

Conclusion:
In the present review, it was found that Res administration is beneficial in GBM therapy by inhibition
of proliferation, viability, and migration via modulation of molecular pathways.
Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells
Authors: Aydinlik Seyma , Erkisa Merve , Ari Ferda , Celikler Serap , Ulukaya Engin 
Published: September 2020

Background:
Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is
a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment is the patients with tumors exhibiting a
KRAS mutation which occurs in approximately 40% of colorectal cancer patients.

Objective:
Hence, we assessed whether a palladium (Pd)(II) complex is a promising anticancer complex, compared to 5-fluorouracil in
KRAS wt HT-29 and KRAS mutant HCT-15 cells.

Methods:
HCT-15 and HT-29 cells were used for colorectal cancer and chloroquine (CQ) was used as an inhibitor of autophagy. In this
context, cells were treated with Pd(II) complex and 5-FU in combination with CQ for 48 h and cell viability was measured by SRB assay.
Cell death mode was examined with M30 and M65 ELISA assays, annexin V/propidium iodide. Autophagy was determined by acridine
orange (AO) staining. Furthermore, the
expression of various autophagy and apoptosis related proteins were evaluated with Western blotting.Luminex assay and reactive oxygen
species (ROS) level were examined.

Results:
Cell viability was found to decrease in a dose-dependent manner and CQ enhanced cytotoxic effect in
Pd(II) and 5-FU treated cells in colorectal cancer cells. Our data showed that inhibition of autophagic flux significantly
increased intrinsic apoptosis through the activation of ROS. We showed that combinatorial treatment
with CQ induced apoptosis via the caspase-dependent mitochondrial pathway. Luminex analysis revealed that the
combination resulted in a down-regulation of NF-κB/AKT/CREB signaling pathways in both cell lines, however,
decreased Erk1/2 protein expression was only observed after treatment with CQ combination in HCT-15 cells.

Conclusion:
We suggest that the inhibition of autophagy along with Pd(II) and 5-FU treatment has a synergistic
effect on KRAS-mutant colorectal cancer cells. Autophagy inhibition by CQ promotes apoptosis via blockade of
the NF-κB/AKT/CREB and activation of ROS.