bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectroscopic and crystallographic characterization of a new cathinone derivative: 1-phenyl-2-(butylamino)hexan-1-one hydrochloride (N-butylhexedrone)
Authors: Rojkiewicz Marcin , Kuś Piotr , Kusz Joachim , Książek Maria , Sochanik Aleksander 
Published: February 2020

Abstract
Purpose
In this study, a new cathinone derivative, N-butylhexedrone, emerged on new psychoactive substances (NPS) market in Poland was described and characterized.

Methods
The compound was analyzed by gas chromatography—mass spectrometry, X-ray crystallography and infrared, Raman, ultraviolet-visible and nuclear magnetic resonance spectroscopic approaches.

Results
We confirmed the presence of the compound in the seized material and obtained detailed and comprehensive physicochemical characterization of N-butylhexedrone—new cathinone derivative available on the NPS market.

Conclusions
In this study, we presented chromatographic, spectroscopic and crystallographic characterization of a new cathinone derivative that emerged on the NPS market in 2019. The obtained analytical data should be useful for forensic and toxicological purposes in quick and reliable compound identification.
Laboratory testing and numerical simulation of properties and thermal-induced cracking of Eibenstock granite at elevated temperatures
Authors: Wang Fei , Konietzky Heinz , Frühwirt Thomas , Dai Yajie 
Published: February 2020

AbstractThe knowledge about thermo-mechanical properties of granite is still limited to some extent. Individual measurements are necessary to obtain reliable properties for specific granite types. A reliable numerical model of thermal cracking behaviours of granite exposed to extreme high temperatures (e.g. 800–1000 °C) is missing. In this study, the impact of temperature up to 1000 °C on physical, mechanical, and thermal properties as well as thermo-mechanical coupled behaviour of Eibenstock granite was investigated by laboratory testing and numerical simulations. The physical properties including mineral composition, density, P-wave velocity, and open porosity are measured to be temperature dependent. Uniaxial compression and Brazilian tests were carried out to measure uniaxial compressive strength (UCS), Young’s modulus, stress–strain relationship, and tensile strength of Eibenstock granite before and after thermal treatment, respectively. Thermal properties including specific heat, thermal conductivity, thermal diffusivity, and linear thermal expansion coefficient are also measured and found to be temperature dependent, especially the expansion coefficient which shows a steep increase around 573 °C as well as at 870 °C. The numerical simulation code FLAC3Dwas used to develop a numerical scheme to simulate the thermal-induced damage of granite at high temperatures. Statistical methods combined with real mineral composition were used to characterize the heterogeneity of granite. The numerical model is featured with reliable temperature-dependent parameters obtained from laboratory tests. It can well reproduce the laboratory results in form of thermal-induced micro- and macrocracks, as well as the stress–strain behaviour and the final failure pattern of Eibenstock granite after elevated temperatures up to 1000 °C. The simulation results also reveal that the thermal-induced microcracks are randomly distributed across the whole sample. Although most thermal-induced damages are tensile failures, shear failure begins to develop quickly after 500 °C. The obvious UCS reduction in granite due to heating is mainly caused by the increase in shear failure. The simulation also shows that the dominant impact ofα–βquartz transition is widening pre-existing cracks rather than the formation of new microcracks.
Effective design of massive open online courses for mathematics teachers to support their professional learning
Authors: Hollebrands Karen F. , Lee Hollylynne S. 
Published: February 2020

AbstractThree MOOCs for Educators (MOOC-Eds) were designed for mathematics and statistics teachers based on principles of effective online professional development that include: self-directed learning, learning from multiple voices, job-connected learning, and peer-supported learning (Kleiman et al., in: Kim (ed) Massive Open Online Courses: the MOOC Revolution, Routledge, New York, 2015). We examined how these design principles were enacted in the development of the MOOC-Eds and how they influenced the engagement of 5767 participants. We also analyzed opportunities the MOOC-Eds provided for participants to develop their knowledge of, beliefs about, and attitudes towards teaching mathematics and statistics. The Interconnected Model of Professional Growth (Clarke and Hollingsworth in Teach Teach Educ 18(8):947–967, 2002) was used to guide analysis of click data, discussion forum posts, and interviews to consider the ways in which elements of the external domain influenced the personal domain of participants. Evidence is presented to illustrate the enactment of design principles and their effects.
Investigating UK consumers’ heterogeneous engagement in demand-side response
Authors: Li Pei-Hao , Keppo Ilkka , Xenitidou Maria , Kamargianni Maria 
Published: February 2020

AbstractDemand-side response (DSR), the incentivised time-shifting of energy use by consumers away from peak times, is regarded as a potentially effective measure to balance electricity supply and demand. This will be even more important in the low-carbon energy system of the future, with a high share of non-dispatchable power, such as variable renewable energy and nuclear power. Most DSR programmes require consumers’ active engagement in shifting end-use activities. Previous studies have, however, rarely revealed socio-demographic factors influential for consumers’ willingness-to-shift specific end-use activities. This study thus aims to fill this research gap and, using a multinomial logistic model to analyse a nationwide survey, identify factors influential for DSR-related decisions. The nationwide survey for 1004 respondents was carried out to collect data about consumers’ willingness-to-shift their daily activities. We focused on the activities that constitute the major part of domestic energy consumption, i.e. cooking, dish-washing, entertainment, heating, laundry and showering. According to the results, consumers’ original timing of the end-use activities, socio-demographic factors, ownership of specific appliances and level of concern for energy-saving are influential for their willingness-to-shift activities. These findings can not only help policymakers make more targeted DSR promotion plans but also help to improve broader modelling tools to better consider consumers’ willingness-to-shift their demand.
Tephritidae fruit fly gut microbiome diversity, function and potential for applications
Authors: Raza Muhammad Fahim , Yao Zhichao , Bai Shuai , Cai Zhaohui , Zhang Hongyu 
Published: February 2020

AbstractThe family Tephritidae (order: Diptera), commonly known as fruit flies, comprises a widely distributed group of agricultural pests. The tephritid pests infest multiple species of fruits and vegetables, resulting in huge crop losses. Here, we summarize the composition and diversity of tephritid gut-associated bacteria communities and host intrinsic and environmental factors that influence the microbiome structures. Diverse members of Enterobacteriaceae, most commonly Klebsiella and Enterobacter bacteria, are prevalent in fruit flies guts. Roles played by gut bacteria in host nutrition, development, physiology and resistance to insecticides and pathogens are also addressed. This review provides an overview of fruit fly microbiome structure and points to diverse roles that it can play in fly physiology and survival. It also considers potential use of this knowledge for the control of economically important fruit flies, including the sterile insect technique and cue-lure baiting.
Multiplicity, Audibility, and Musical Continuity
Authors: ALWARD PETER 
Published: February 2020

ABSTRACTMusical works are both multiple — they have a plurality of instances — and audible — they can be heard by listening to their instances. Two prominent approaches to musical ontology designed to explain these features of musical works are the type-token model and the continuant-stage model. Julian Dodd has argued that the type-token model has an advantage over the continuant-stage model because it can offer a direct explanation of the audibility of musical works in terms of their ontological category. In this paper, I defend the continuant-stage model against Dodd's argument by invoking a work-unifying continuity relation.
THE MEXICAN EXPEDITION OF 1862–1867 AND THE END OF THE FRENCH SECOND EMPIRE
Authors: GREENFIELD JEROME 
Published: February 2020

AbstractThe French expedition to Mexico from 1862 to 1867 rarely features in accounts of the origins of the Franco-Prussian War or of the liberalization of the French Second Empire in its final years. By contrast, this article uses a range of archival and published sources to argue that the failure of the Mexican expedition was an important factor in the crisis that convulsed French politics in the late 1860s. The legitimacy of the fiscal-military system was undermined, partly because of the burdens that the expedition imposed on the French people. There resulted difficulties over finance and the army, which hindered the Second Empire's ability to confront the Prussian threat and accelerated the emergence of the ‘Liberal Empire’ with the constitutional reforms of 1867–70. Liberalization, though, could not rescue the imperial regime, and the legitimacy crisis of the Second Empire was only resolved by a transition to a parliamentary democracy under the Third Republic.
US Topographics: Imaging National Landscapes
Authors: BLINDER CAROLINE , LLOYD CHRISTOPHER 
Published: February 2020

In 1975, the New Topographics: Photographs of a Man-Altered Landscape exhibition, organized by William Jenkins, at George Eastman House, changed the scope and aesthetics of American landscape photography. Ostensibly pared-back and banal, these black-and-white images formally presented the United States as a series of streets, suburban new builds, industrial sites and warehouses. None bigger than eleven inches by four or thirteen by thirteen, the photographs were also small and unassuming, refusing the grandness and potential sublimity of previous evocations of the US landscape. Rather than present the United States as a series of locations marked by regional and economic differences, photographers such as Robert Adams, Frank Gohlke, Lewis Baltz and Bernd and Hilla Becher now focussed on an increasing homogeneity across terrains, terrains often indeterminable in terms of actual locations, and, more often than not, eerily devoid of human presence. In Neil Campbell's words, the images were “unemotional, flat and appeared everyday, aspiring to ‘neutrality’ with a ‘disembodied eye.’” The New Topographics – according to such readings – differed from earlier depictions of the United States, moving away from the documentary focus on agrarian poverty and urban slums as seen during the Depression, as well as the humanist vision of postwar photographers such as Robert Frank. As William Jenkins put it in the original introduction to the exhibition, New Topographics was a study more “anthropological than critical,” one that would recentre everyday lived experience – not as a collection of individualized narratives, but as a cultural landscape marked by commercial interests above all.
Minimally invasive surgery under local anaesthesia for chronic rhinosinusitis with nasal polyps: our experience in older adults
Authors: Casale M , Costantino A , Sabatino L , Luchena A , Moffa A , Cassano M , Rinaldi V , Baptista P M 
Published: February 2020

AbstractObjectiveThis paper aims to report our experience with a minimally invasive surgical procedure for the treatment of chronic rhinosinusitis with nasal polyps, performed in a day-surgery setting under local anaesthesia.MethodsA retrospective study of 30 patients with chronic rhinosinusitis with nasal polyps was conducted. Sino-Nasal Outcome Test 22 and modified Lund–Kennedy scores were collected. Intra- and post-operative pain was evaluated using a 10-point visual analogue scale.ResultsThe mean Sino-Nasal Outcome Test 22 score decreased from 41.8 ± 15.8 pre-operatively to 13.3 ± 9.5 post-operatively (p < 0.001). Accordingly, the mean endoscopic score decreased from 6.8 ± 1.8 to 0.2 ± 0.7 (p < 0.001). The mean intra-operative pain score was 2.9 ± 3.2, and 29 patients (96.7 per cent) reported no pain in the post-operative period (visual analogue scale score = 0).ConclusionOur study confirms that minimally invasive surgery represents a safe, repeatable procedure that results in remarkable subjective and objective improvement, without intra- and post-operative pain or discomfort.
The effects of job characteristics on retirement
Authors: Hudomiet Péter , Hurd Michael D. , Parker Andrew M. , Rohwedder Susann 
Published: February 2020

AbstractAlong with data about actual, desired, and anticipated job characteristics, this paper uses a novel data element, the subjective conditional probability of working at age 70, to estimate the causal effects of job characteristics on retirement in the United States. Having flexible work hours is the most consistent predictor of retirement preferences and expectations: if all current workers had flexible hours, the fraction working at age 70 would be 0.322, but it would be just 0.172 if none had this option. Job stress, physical, and cognitive job demands, the option to telecommute, and commuting times were additional predictors of retirement expectations.
Assessment of Model Drifts in Seasonal Forecasting: Sensitivity to Ensemble Size and Implications for Bias Correction
Authors: Manzanas Rodrigo 
Published: February 2020

AbstractDespite its systematic presence in state‐of‐the‐art seasonal forecasts, the model drift (leadtime‐dependent bias) has been seldom studied to date. To fill this gap, this work analyzes its spatiotemporal distribution, and its sensitivity to the ensemble size in temperature and precipitation forecasts. Our results indicate that model continues to drift well beyond the first month after initialization, leading to significant, highly space‐ and time‐varying drifts over vast regions of the world. Nevertheless, small ensembles (less than 10 members) are enough to robustly estimate the mean model drift and its year‐to‐year fluctuations in skillful regions. Differently, in regions of low model skill, larger ensembles are required to appropriately characterize this interannual variability, which is often larger than the drift itself. This points out a necessity to develop new strategies that allow for efficiently dealing with model drift, especially when bias correcting seasonal forecasts—most of the techniques used to this aim rely on the assumption of stationary model errors. We demonstrate here that the use of moving windows can help to remove not only the mean forecast bias but also the unwanted effects coming out from the drift, which can lead to important intraseasonal biases if it is not properly taken into account. The results from this work can help to identify the nature and causes of some of the systematic errors in current coupled models and can have large implications for a wide community of users who need long, continuous unbiased seasonal forecasts to run their impact models.
Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke
Authors: von Berg Joanna , van der Laan Sander W. , McArdle Patrick F. , Malik Rainer , Kittner Steven J. , Mitchell Braxton D. , Worrall Bradford B. , de Ridder Jeroen , Pulit Sara L. 
Published: February 2020

AbstractIschemic stroke (IS), caused by obstruction of cerebral blood flow, is one of the leading causes of death. While neurologists agree on delineation of IS into three subtypes (cardioembolic stroke (CES), large artery stroke (LAS), and small vessel stroke (SVS)), several subtyping systems exist. The most commonly used systems are TOAST (Trial of Org 10172 in Acute Stroke Treatment) and CCS (Causative Classification System for Stroke), but agreement is only moderate. We have compared two approaches to combining the existing subtyping systems for a phenotype suited for a genome-wide association study (GWAS). We used the NINDS Stroke Genetics Network dataset (SiGN, 11,477 cases with CCS and TOAST subtypes and 28,026 controls). We defined two new phenotypes: the intersect, for which an individual must be assigned the same subtype by CCS and TOAST; and the union, for which an individual must be assigned a subtype by either CCS or TOAST. The union yields the largest sample size while the intersect yields a phenotype with less potential misclassification. We performed GWAS for all subtypes, using the original subtyping systems, the intersect, and the union as phenotypes. In each subtype, heritability was higher for the intersect compared with the other phenotypes. We observed stronger effects at known IS variants with the intersect compared with the other phenotypes. With the intersect, we identify rs10029218:G>A as an associated variant with SVS. We conclude that this approach increases the likelihood to detect genetic associations in ischemic stroke.
Disease Classification in Eggplant Using Pre-trained VGG16 and MSVM
Authors: Krishnaswamy Rangarajan Aravind , Purushothaman Raja 
Published: February 2020

AbstractCurrently, the application of deep learning in crop disease classification is one of the active areas of research for which an image dataset is required. Eggplant (Solanum melongena) is one of the important crops, but it is susceptible to serious diseases which hinder its production. Surprisingly, so far no dataset is available for the diseases in this crop. The unavailability of the dataset for these diseases motivated the authors to create a standard dataset in laboratory and field conditions for five major diseases. Pre-trained Visual Geometry Group 16 (VGG16) architecture has been used and the images have been converted to other color spaces namely Hue Saturation Value (HSV), YCbCr and grayscale for evaluation. Results show that the dataset created with RGB and YCbCr images in field condition was promising with a classification accuracy of 99.4%. The dataset also has been evaluated with other popular architectures and compared. In addition, VGG16 has been used as feature extractor from 8th convolution layer and these features have been used for classifying diseases employing Multi-Class Support Vector Machine (MSVM). The analysis depicted an equivalent or in some cases produced better accuracy. Possible reasons for variation in interclass accuracy and future direction have been discussed.
Return to work and clinical outcome after surgical treatment and conservative management of patients with intramedullary spinal cord ependymoma
Authors: Behmanesh Bedjan , Gessler Florian , Won Sae-Yeon , Dubinski Daniel , Quick-Weller Johanna , Imoehl Lioba , Seifert Volker , Marquardt Gerhard 
Published: February 2020

AbstractThe ability to return to work after treatment of diseases is an important issue. Aim of this study is to compare surgery and conservative management focusing on clinical outcome and ability to return to work in patients with intramedullary spinal cord ependymoma. Retrospective, single center study. The neurological status at first presentation, as well as in long-term follow-up, were assessed using the modified McCormick Disability Scale and modified Rankin Scale. The study population consisted of 56 patients, 23 (41%) were managed conservatively and 33 (59%) underwent microsurgical resection. The median age was 47.5 years in the conservative group and 44.5 in the surgical group. At first admission 18 of conservatively treated and 28 of surgically treated patients were employed, p = 0.7. At the last follow-up 15 (83%) of conservatively and 10 (36%) of surgically treated patients returned to work, p = 0.002. The median modified McCormick score in both groups (conservative vs. surgical) was at admission 1 vs. 1, p = 1.0 and at last follow up 1 vs. 2.5, p = 0.001. Patients clinical outcome in the surgical group was significantly reduced at last follow up as assessed by the modified Rankin Scale (mRs score of 0–2) at admission 100% vs. 100% and last follow-up 94% vs. 57%, p = 0.007. In our investigated study population, conservatively managed patients revealed a significantly better outcome and were more often able to return to work.
Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis
Authors: Dai Jian-bo , Zhu Bei , Lin Wei-jia , Gao Hai-yan , Dai Hong , Zheng Lin , Shi Wei-hai , Chen Wei-xian 
Published: February 2020

Abstract
Aims: Baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5) plays vital roles in carcinogenesis by influencing cell division and proliferation and by inhibiting apoptosis. However, the prognostic significance of BIRC5 remains unclear in breast cancer.
Methods: BIRC5 expression and methylation status were evaluated using the Oncomine and The Cancer Genome Atlas (TCGA) databases. The relevance between BIRC5 and different clinicopathological features as well as survival information was analyzed using the bc-GenExMiner database and Kaplan–Meier Plotter. BIRC5–drug interaction network was obtained using the Comparative Toxicogenomics Database.
Results: Based on the results from databases and own hospital data, BIRC5 was higher expressed in different breast cancer subtypes compared with the matched normal individuals. Hormone receptors were negatively correlated with BIRC5 expression, whereas the Scarff–Bloom–Richardson (SBR) grade, Nottingham Prognostic Index (NPI), human epidermal growth factor receptor-2 (HER-2) status, basal-like status, and triple-negative status were positively related to BIRC5 level in breast cancer samples with respect to normal tissues. High BIRC5 expression was responsible for shorter relapse-free survival, worse overall survival, reduced distant metastasis free survival, and increased risk of metastatic relapse event. BIRC5–drug interaction network indicated that several common drugs could modulate BIRC5 expression. Furthermore, a positive correlation between BIRC5 andcell-division cycle protein 20 (CDC20) gene was confirmed.
Conclusion: BIRC5 may be adopted as a promising predictive marker and potential therapeutic target in breast cancer. Further large-scale studies are needed to more precisely confirm the value of BIRC5 in treatment of breast cancer.
Clinical Practice Recommendations for Improving Life Participation for People With Aphasia in Long-Term Care
Authors: Azios Jamie H. , Damico Jack S. 
Published: February 2020

Purpose
The purpose of this clinical focus article is to present an overview of the Life Participation Approach to Aphasia as it relates to issues in long-term care (LTC) and provide practical recommendations for implementing the approach in this setting. The Framework for Living With Aphasia is used as a guide to (a) highlight specific challenges to life participation for residents with aphasia in LTC and (b) propose clinical tools that might help clinicians move through the therapeutic process when implementing the Life Participation Approach to Aphasia.

Recommendations
Clinicians in LTC facilities have the responsibility of delivering services that have a positive impact on communication, social relationships, emotional health, and quality of life. Clinical tools and approaches most appropriate for LTC settings are identified that help to address these goals. Approaches are discussed across several stages representing the therapeutic process, which is ultimately aimed at moving a resident toward recovery and increased independence. Case demonstrations are provided to illustrate approaches.