bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors for disease recurrence in patients with locally advanced renal cell carcinoma treated with curative surgery
Authors: Chang Te-Wei , Cheng Wei-Ming , Fan Yu-Hua , Lin Chih-Chieh , Lin Tzu-Ping , Huang Eric Yi-Hsiu , Chung Hsiao-Jen , Huang William J.S. , Chang Yen-Hwa , Lin Alex T.L. 
Published: April 2020

Abstract
Background Few prognostic factors have been proposed for patients with locally advanced renal cell carcinoma (RCC). This study aimed to investigate the possible predictive factors for disease-free survival (DFS) after curative surgery for RCC stage T3 or higher. Methods Patients with locally advanced RCC who underwent cure-intended partial or radical nephrectomy, with or without tumor thrombectomy, at our institution from April 1 st , 2005 to October 31 st , 2013 were retrospectively reviewed. Those undergoing cytoreductive nephrectomy were excluded. Preoperative data, including surgical and pathologic characteristics, were assessed for correlation with DFS. Chi-squared tests, multivariate Cox regression analysis, and Kaplan-Meier survival curve analyses were performed to determine potential predictive factors. A P-value less than 0.05 was considered statistically significant. Results A total of 159 patients were included for analysis. One hundred and nineteen (74.8%) patients remained disease-free during follow-up. Disease recurrence was found in 40 (25.2%) patients, and pathological T stage, capsule penetration, Fuhrman grade, thrombocytosis, and elevated serum alkaline phosphatase and γ-glutamyl transpeptidase levels were significantly associated with disease recurrence on univariate analysis. On multivariate analysis, capsule penetration (hazard ratio [HR] = 2.25, p = 0.038, 95% confidence interval [CI] = 1.05–4.85) and Fuhrman grade 3 or 4 (HR = 8.06, p = 0.003, 95% CI = 2.59–25.02) showed significant associations with DFS. Conclusions In patients with locally advanced RCC, capsule penetration and Fuhrman grade were associated with worse DFS after curative surgery. Urologists should closely monitor patients with capsule penetration and high Fuhrman grades, and adjuvant systemic treatments, other than targeted agents, should be considered.
Removal of Hg2+, Pb2+, Zn2+ and Cu2+ ions from Contaminated Water Using Caladium bicolor (Wild Cocoyam)
Authors: Ayim Emmanuel , Agongo Julius , Sakyi Patrick Opare , Asamoah Benjamin Darko , Bienibuor Alfred K , Aidoo Philip , Emahi Ismaila 
Published: April 2020

Abstract
Heavy metal persistence in the environment is a global threat and researchers continue to explore low-cost effective technologies for removing these contaminants from the environment. In this study, the ability of Caladium bicolor (biosorbent) to remove lead, zinc, copper and mercury ions from the contaminated water was explored. At 2 ppm metal ion concentration, the biosorbent was able to remove all four metal ions with a low removal efficiency of 79.5% for Hg2+ and a high of 99.5% for Pb2+. The effectiveness of the biosorbent, however, decreased when the metal ion concentration was increased beyond 2 ppm. Specifically, the biosorbent’s effectiveness was studied at 5, 10, 25, and 50 ppm metal ion concentrations. Interestingly, the decrease in effectiveness with regards to Pb2+ was relatively marginal, suggesting a stronger preference of Caladium bicolor for lead. In order to determine optimal conditions required for effective adsorption or high metal removal efficiencies, the effect of biosorbent mass and contact time for equilibration of the biosorbent with the metals were also investigated. While 30 min contact time was found to be adequate for effective metal removal, there was no significant difference in the results obtained when 0.5 g vs 2.0 g of the biosorbent was used. FT-IR analyses also revealed that similar functional groups were responsible for the removal of all the four metals studied.
Insight from a noticeable difference between two families infected with COVID-19
Authors: Cao Shugang , Li Yuancheng , Yue Hong , Li Chenchen , Xia Mingwu , Liu Fang , Wu Juncang 
Published: April 2020

Abstract
The outbreak of COVID-19 shows a high potent of person-to-person transmission and thus contributes to a large spread of infection sweeping the world. The family cluster of infection has been paid much more attention. We reported two different families infected by SARS-CoV-2 in the context of family clustering, one of which is a typical family cluster of infection with the transmission chain being an asymptomatic patient in the incubation period. However, the outcome of another family was exactly the opposite, in which the index patient was the only individual infected and complicated with fatal ischemic stroke. These two families highlight that more attention should be paid to the distinctions underlying the family cluster of infections and the possibility of COVID-19-related stroke.
The first Jordanian newborn delivered to COVID-19 infected mother with no evidence of vertical transmission: A case report.
Authors: Khassawneh Mohammad , Khasawneh Wasim , Zaghal Laila Al , Hayajneh Wail , Abdelal Fadel 
Published: April 2020

Abstract
Background: COVID-19 has been recently declared by WHO a global health pandemic. Theoretically, it might affect all age groups but it is not known if vertical transmission during pregnancy occurs. We hereby report a case about the first Jordanian newborn delivered to COVID-19 infected mother. Case presentation: A late preterm female was delivered by Cesarean section to COVID-19 mother who was diagnosed after presenting with a dry cough, nasal congestion, headache, and sore throat in the context of direct contact with other confirmed patients. The infant’s clinical examination was reassuring throughout the hospital stay. COVID-19 was not detected by RT-PCR tests performed on the amniotic fluid and on two samples of the newborn’s nasopharyngeal swabs indicating no vertical transmission of the virus. After 10 days of hospital stay and following two negative consecutive RT-PCR assays on the mother’s nasopharyngeal swabs, both the mother and the infant were discharged home in stable clinical conditions. Conclusion: Vertical transmission is not likely among the routes of COVID-19 transmission. However, data about more number of deliveries to COVID-19 infected mothers is needed to support this conclusion.
El fenómeno de frontera y sus variables. Notas para una tipología
Authors: Jiménez Alfredo 
Published: April 2020

Las fronteras han sido y son tan diversas que resulta conveniente la elaboración de tipologías que permitan la formación de conjuntos o clusters relativamente homogéneos. Estas tipologías favorecen el análisis comparativo y el mejor entendimiento de los casos particulares y del fenómeno en general. Se señalan algunas de las variables más significativas que intervienen en estos procesos, con especialreferencia a la América de habla hispana.
Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents
Authors: Monteiro Kadja L.C. , Alcântara Marcone G. dos S. , de Aquino Thiago M. , da Silva-Júnior Edeildo F. 
Published: April 2020

:
Major research in Alzheimer’s disease (AD) related to disease-modifying agents is concentrated on
pharmacological approaches related to diagnostic markers, neurofibrillary tangles and amyloid plaques. Although
most studies focus on anti-amyloid strategies, investigations on tau protein have produced significant advances in
the modulation of the pathophysiology of several neurodegenerative diseases. Since the discovery of phenothiazines
as tau protein aggregation inhibitors (TAGIs), many additional small molecule inhibitors have been discovered
and characterized in biological model systems, which exert their interaction effects by covalent and noncovalent
means. In this paper, we summarize the latest advances in the discovery and development of tau aggregation
inhibitors using a specialized approach in their chemical classes. The design of new TAGIs and their encouraging
use in in vivo and clinical trials support their potential therapeutic use in AD.
Erectile Dysfunction as a Cardiovascular Risk Factor: Time to Step Up?
Authors: Imprialos Konstantinos , Koutsampasopoulos Konstantinos , Manolis Athanasios , Doumas Michael 
Published: April 2020

Background:Erectile dysfunction (ED) is a major health problem that affects a significant proportion of the general population, and its prevalence is even higher in patients with CV risk factors and/or disease. ED and cardiovascular (CV) disease share several common pathophysiological mechanisms, and thus, the potential role of ED as a predictor of CV events has emerged as a significant research aspect.Objective:The purpose of this review is to present and critically discuss data assessing the relation between ED and CV disease and the potential predictive value of ED for CV events.Method:A comprehensive review of the literature has been performed to identify studies evaluating the association between ED and CV disease.Results:Several cross-sectional and prospective studies have examined the association between ED and CV disease and found an increased prevalence of ED in patients with CV disease. ED was shown to independently predict future CV events. Importantly, ED was found to precede the development of overt coronary artery disease (CAD) by 3 to 5 years, offering a “time window” to properly manage these patients before the clinical manifestation of CAD. Phosphodiesterase type 5 inhibitors are the first-line treatment option for ED and were shown to be safe in terms of CV events in patients with and without CV disease.Conclusion:Accumulating evidence supports a strong predictive role of ED for CV events. Early identification of ED could allow for the optimal management of these patients to reduce the risk for a CV event to occur.
A Multi-Method and Structure-Based In Silico Vaccine Designing Against Helicobacter pylori Employing Immuno-Informatics Approach
Authors: Naz Anam , Zaheer Tahreem , Dar Hamza Arshad , Awan Faryal Mehwish , Obaid Ayesha , Ashraf Shifa Tariq , Paracha Rehan Zafar , Malik Arif , Ali Amjad 
Published: April 2020

Background:
Helicobacter pylori infection and its treatment still remain a challenge for
human health worldwide. A variety of antibiotics and combination therapies are currently used to
treat H. pylori induced ulcers and carcinoma; however, no effective treatment is available to eliminate
the pathogen from the body. Additionally, antibiotic resistance is also one of the main reasons
for prolonged and persistent infection.

Aims:
Until new drugs are available for this infection, vaccinology seems the only alternative opportunity
to exploit against H. pylori induced diseases.

Methods:
Multiple epitopes prioritized in our previous study have been tested for their possible
antigenic combinations, resulting in 169-mer and 183-mer peptide vaccines containing the amino
acid sequences of 3 and 4 epitopes respectively, along with adjuvant (Cholera Toxin Subunit B adjuvant
at 5’ end) and linkers (GPGPG and EAAAK).

Results:
Poly-epitope proteins proposed as potential vaccine candidates against H. pylori include
SabA-HP0289-Omp16-VacA (SHOV), VacA-Omp16-HP0289-FecA (VOHF), VacA-Omp16-HP0289-
SabA (VOHS), VacA-Omp16-HP0289-BabA (VOHB), VacA-Omp16-HP0289-SabA-FecA
(VOHSF), VacA-Omp16-HP0289-SabA-BabA (VOHSB) and VacA-Omp16-HP0289-BabA-SabA
(VOHBS). Structures of these poly-epitope peptide vaccines have been modeled and checked for
their affinity with HLA alleles and receptors. These proposed poly-epitope vaccine candidates bind
efficiently with A2, A3, B7 and DR1 superfamilies of HLA alleles. They can also form stable and
significant interactions with Toll-like receptor 2 and Toll-like receptor 4.

Conclusion:
Results suggest that these multi-epitopic vaccines can elicit a significant immune response
against H. pylori and can be tested further for efficient vaccine development.
Cannabis and Illicit Drug Use During Neurodevelopment and the Associated Structural, Functional and Cognitive Outcomes: Protocol for a Systematic Review
Authors: Debenham Jennifer , Newton Nicola , Birrell Louise , Yücel Murat , Lees Briana , Champion Katrina 
Published: April 2020

Background
High rates of cannabis and illicit drug use are experienced by young people during the final stages of neurodevelopment (aged 15-24 years), a period characterized by high neuroplasticity. Frequent drug use during this time may interfere with neurophysiological and neuropsychological development pathways, potentially leading to ongoing unfavorable neuroadaptations. The dose-response relationship between illicit drug use, exposure, and individual neurodevelopmental variation is unknown but salient with global shifts in the legal landscape and increasingly liberal attitudes and perceptions of the harm caused by cannabis and illicit drugs.

Objective
This systematic review aims to synthesize longitudinal studies that investigate the effects of illicit drug use on structural, functional, and cognitive brain domains in individuals under the neural age of adulthood (25 years). This protocol outlines prospective methods that will facilitate an exhaustive review of the literature exploring pre- and post-drug use brain abnormalities arising during neurodevelopment.

Methods
Five electronic databases (Medline, Embase, PsycINFO, ProQuest Central, and Web of Science) will be systematically searched between 1990 and 2019. The search terms will be a combination of MeSH (Medical Subject Headings), with keywords adapted to each database. Study reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and if relevant, study quality will be assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. Eligible studies are those that sampled youth exposed to cannabis or illicit drugs and employed neurophysiological or neuropsychological assessment techniques. Studies will be excluded if participants had been clinically diagnosed with any psychiatric, neurological, or pharmacological condition.

Results
This is an ongoing review. As of February 2020, papers are in full-text screening, with results predicted to be complete by July 2020.

Conclusions
Integrating data collected on the three brain domains will enable an assessment of the links between structural, functional, and cognitive brain health across individuals and may support the early detection and prevention of neurodevelopmental harm.

Trial Registration
PROSPERO CRD42020151442; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=151442

International Registered Report Identifier (IRRID)
PRR1-10.2196/18349
Techniques of Acquisition and Processing of Electrocardiographic Signals in the Detection of Cardiac Arrhythmias
Authors: Barbosa Casanova Giovanny , Cardozo Sarmiento Darwin Orlando , Illera Bustos Mario Joaquin , Orozco Duque Andrés , Andrade Caicedo Henry 
Published: April 2020

The development of ambulatory monitoring systems and its electrocardiographic (ECG) signal processing techniques has become an important field of investigation, due to its relevance in the early detection of cardiovascular diseases such as the arrhythmias. The current trend of this technology is oriented to the use of portable equipment and mobile devices such as Smartphones, which have been widely accepted due to the technical characteristics and common integration in daily life. A fundamental characteristic of these systems is their ability to reduce the most common types of noise by means of digital signal processing techniques. Among the most used techniques are the adaptive filters and the Discrete Wavelet Transform (DWT) which have been successfully implemented in several studies. There are systems that integrate classification stages based on artificial intelligence, which increases the performance in the process of arrhythmias detection. These techniques are not only evaluated for their functionality but for their computational cost, since they will be used in real-time applications, and implemented in embedded systems. This paper shows a review of each of the stages in the construction of a standard ambulatory monitoring system, for the contextualization of the reader in this type of technology.
Evaluation of induction of somatic embryogenesis from cotyledonary leaves of Banana Passion fruit (Passiflora mollissima) L.H Bailey
Authors: Parra Peñalosa Oscar José , Cancino Escalante Giovanni Orlando 
Published: April 2020

Passiflora mollissima L.H Bailey is an endemic species from the Andes mountain of Colombia in South America with important edible fruits and medicinal and economical properties. The development of improved micropropagation techniques is necessary to provide rapid and efficient clonal propagation of elite genotypes with high resistance and uniform production, as well as a system that can be used for genetic transformation. For this reason, the investigation focused on the evaluation of induction of somatic embryogenesis in P. mollissima from cotyledonary leaves, the effect of growth regulator concentrations and the orientation of explants on embryo production. Histological analyses of somatic embryogenesis were performed every 10 days after induction over 38 days of exposure to the medium. Results showed somatic embryo formation on Murashige and Skoog, (1962) culture medium supplemented with 4.5 μM 2,4-diclorophenoxyacetic acid plus 4.5 μM 6-benzyladenine. The results obtained are applicable to knowledge of non-zygotic embryogenesis in passionflower of the Andean region, for the purpose of improvement and commercial use. It is noteworthy that this is the first study in the induction and obtaining of embryos in P. mollissima.
El dilema de la guerra o la paz: representaciones sociales sobre la paz de jóvenes del colegio San José de Cúcuta
Authors: Jaimes Marquez Maritza Carolina , Galvis Velandia Laura Nataly , Guiza Castellanos Miguel Augusto 
Published: April 2020

El presente artículo expone el desarrollo y resultados de la investigación que tiene como título el dilema de la guerra o la paz: representaciones sociales sobre la paz de jóvenes del colegio san José de Cúcuta, el objetivo general fue Comprender las Representaciones Sociales de paz de los jóvenes estudiantes de la institución educativa San José de Cúcuta como fundamento a una práctica pedagógica. Las teorías aplicadas fueron las representaciones sociales, los modelos pedagógicos y una mirada hermenéutica en la práctica pedagógica, que desde la rigurosidad permiten dar una mirada crítica frente a la investigación, asimismo, se fundamenta en una investigación cualitativa, con un diseño hermenéutico, encaminada a dar respuesta a los interrogantes aquí generados y los objetivos mencionados con anterioridad.
Improving students' ability to write narrative texts using pictures
Authors: Eliyawati Eliyawati 
Published: April 2020

This study is aimed in improving students' writing ability by using pictures in narrative text for Grade XI- IPS 5 SMA N 1 Cigugur Kuningan, the survey used of t-test data of experimental and control groups on pre-test and the shows that tactic is lower that ttab (0, 07 ˂ 1, 6759) that is no significant difference of pre-test mean of both groups. The result of there are given a different treatment, and it means that there is a considerable difference in the post-test way of both groups, which is the post-test mean of the experimental group is significantly higher. The result t-test of a hypothesis test in the experimental group, whit is tactic ˃ tab or 9, 72 ˃ 1, 7081 so the alternative hypothesis (Ha) the researcher found that the students gave positive responses on the use of the picture on student narrative writing skill. The results of the questionnaire analysis were only offered to the experimental group, which for the affective aspect was 370 or with the "agreed" criteria, for cognitive perspective are 170. It indicates the students' feeling toward English subject commonly, writing activity, and writing narrative text using picture especially is good. For the behaviour is 273 or in the "strongly agree" criteria. It indicates using snapshot is very good, an idea or belief toward English is essential are excellent, and they also agreed toward the difficulties of writing text without any media. After using a picture in writing narrative activity, these conclude that picture is significantly improving student narrative writing skill, and It's they made a considerable improvement in some aspect of writing skills such as content, organization, vocabulary and grammar.
Analisis Penentuan Pola Produksi Dalam Upaya Meminimalisasi Biaya Produksi Dengan Metode Incremental Cost
Authors: Ningtyas Aneke Ayu Putri , Adjie Setyo , Wijianto Wijianto 
Published: April 2020

This study discusses efforts to minimize production costs at the Ponorogo "Sweep Jagad" Production House by taking into account additional costs that may occur during production activities, including saving costs, overtime costs, subcontracting costs, and labor turnover costs. Through the application of production patterns with three alternatives, namely constant production patterns, corrugated production patterns, and moderate production patterns, a clear picture of production can be carried out by companies in the future. The results obtained indicate that there are significant differences in the production costs of the three production patterns. Value of costs in a constant production pattern of Rp. 5,240,500, then the corrugated production pattern of Rp. 1,676,000, then the moderate production pattern of Rp. 6,744,500. Therefore the production pattern that is able to minimize production costs is a corrugated production pattern.
Analisis Transparansi, Optimalisasi Pengelolaan Zakat dan Efisiensi Terhadap Lembaga Zakat Infaq dan Shodaqoh Muhammadiyah (LAZISMU) Kabupaten Ponorogo
Authors: Novitasari Erma , Rapini Titi , Riawan Riawan 
Published: April 2020

Many zakat institutions are competing to get a lot of funds but still do not pay attention to what they should pay attention to in accordance with the Shari’a and applicable rules. The existence of this research is to see the extent of transparency, optimization and efficiency level of zakat funds at the amil Zakat, Infaq and Shodaqoh Muhammadiyah Ponorogo institutions which have been available since 2005. The date used are primary and secondary date obtained from LAZISMU Ponorogo with interview techniques. The results of the discussion of this thesis is that the transparency variable is said to be transparency buy there are some shortcomings. The optimization variable can be said to be optimal although there is also something that needs to be added as an amplifier and the efisiency variable is very efficient with a value in 2017 of 17,19% and in 2018 of 18,15% an increase in the level of efisiency is due to the addition of employees.