bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of a production process under uncertainty
Authors: Pusztai László , Kocsi Balázs , Budai István , Nagy Lajos 
Published: August 2020

Abstract:A key role of production managers at manufacturing companies is to make economy-based decisions related to production scheduling. If the production is subject to uncertain factors, like human resource or lack of standardization, production planning becomes difficult and calls for advanced models that are tailored to the manufacturing process. This research investigates a real furniture manufacturing system from both managerial and materialflow points of view. Statistical simulation was run on the manufacturing process, where the possible production structures were given. ANOVA analysis was calculated in order to identify those activities that have the most significant influence on the profit.
Modeling and robotic handling of a snap-fitting box buckle
Authors: Rónai László , Szabó Tamás 
Published: August 2020

Abstract:Modeling and robotic handling of a plastic box buckle is discussed in this paper. The closing mechanism of the box buckle is simulated to determine the characteristic of the nonlinear load-deflection curve. An intelligent end-effector was designed and manufactured to handle the assembly with a robot. The closing force is measured by a built-in load cell and its values are processed by a micro-controller. The intelligent end-effector can be used in a robotic system, which deals with different snap-fit applications.
Hyperexpression of TLR2 and TLR4 in patients with ischemic stroke in acute period of the disease
Authors: Gankovskaya L. V. , Stakhovskaya L. V. , Grechenko V. V. , Koltsova E. A. , Uvarova O. S. , Demina M. D. , Gromova T. V. , Svitich O. A. 
Published: August 2020

Pathogenesis of ischemic stroke is actively involved in the system of innate immunity. Under conditions of cerebral ischemia, a number of biologically active substances are released that interact with innate immunity receptors, in particular TLR2 and TLR4, which exacerbate inflammation in brain tissue. Identification of predictor markers at the level of the innate immunity system may foresee the clinical course of ischemic stroke and ensure timely treatment. Our objective was to study expression of TLR2 and TLR4 receptors in peripheral blood leukocytes in patients with ischemic stroke in the dynamics of the disease. 27 people were included in the study. The main group consisted of patients with ischemic stroke of varying severity (n = 19). Patients of the main group were divided into two subgroups: with an NIHSS index value of < 10 (n = 10) and > 10 (n = 9). The control group included healthy donors with no history of acute and chronic inflammatory diseases (n = 8). Peripheral blood leukocytes were used as the test material. To determine expression of the TLR2 and TLR4 genes, RT-PCR in real time was used. Surface expression of TLRs was determined by flow cytometry. A study of the TLR2 and TLR4 gene expression showed that on the 1st, 3rd and 7th day post-stroke, the TLR4 gene expression in patients was significantly increased, when compared to the control group (p < 0.01), whereas TLR2 gene expression on the 3rd day of the disease was not statistically different from the control group. A study of surface expression of receptors showed that the average TLR2 fluorescence intensity on the patients’ peripheral blood monocytes was significantly increased on the 1st and 3rd day of disease when compared to the control group. The surface expression of TLR4 on monocytes has a statistically significant increase only on day 7. Assessment of surface expression of TLRs in subgroups with different severity values by NIHSS showed that patients with a NIHSS index > 10 had a significantly higher level of surface of TLR2 expression over the observation period, while the largest difference in TLR4 expression in the subgroups was observed on the 1st day of the disease (p < 0.05). Patients with ischemic stroke showed an increase in TLR2 and TLR4 expression at the gene and protein level, compared to healthy donors. These indices can be considered possible predictors for clinical prognosis of ischemic stroke.
Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
Authors: Pivovarova L. P. , Gromov M. I. , Tulupov A. N. , Lapshin V. N. , Osipova I. V. , Ariskina O. B. , Nikitin A. V. , Malyshev M. E. , Markelova E. V. 
Published: August 2020

The aim of the study was to evaluate the effect of sodium deoxyribonucleate on anti-infectious resistance and hematopoiesis in patients with polytraumas. A single-center study of sodium deoxyribonucleate effectiveness approved by the local Ethics Committee (protocol No. 4 05/18/2016), was conducted in 54 patients with polytrauma. The main group included 27 people, at the mean age of 39 (29-51) years old; ISS severity score, 26 (22-34). The comparison group comprised 27 people, mean age, 40 years old (26-53), mean ISS severity score was 25 points (20 to 29). The patients with randomly attributed even numbers were injected with 5 ml preparation from vials of even-numbered series, the patients with odd numbers were treated with preparation from the odd-numbered series. They were injected intramuscularly daily from day 1 to day 10 after the injury. Before treatment, as well as on days 8, 15 after injury, peripheral blood was examined for leukocyte, erythrocyte counts, hemoglobin, total protein, blood IL-6, CRP; proportion of CD117+ and CD34+ mononuclear cells, CD14+ monocytes, CD14+ granulocytes, HLA-DR+ mononuclear cells, defensin + granulocytes.On the day +8, patients from the main group, against the comparison group showed an increase in lymphocytes, monocytes, CD117+ and CD34+ cell counts. Serum IL-6 and CRP were decreased in both groups of the patients to a similar degree. Terms of hospitalization in the main group were 32.8 days, against 39.6 in comparison group. The number of complications per 1 case was, respectively, 21 versus 39, thus being 1.8 times less than in comparison group. When developing complications, anemia (Hb < 90 g/l), or hypoproteinaemia (< 60 g/l) in the main group was, respectively, 2.5and 3.5-fold less than in the comparison group.Treatment with sodium deoxyribonucleate in polytrauma may promote migration of blood precursors to the bloodstream, increase anti-infectious properties of leukocytes, reduce duration of anemia and hypoproteinemia, number of complications and decrease the terms of hospitalization.
MALDI-TOF mass spectrometric protein profiling of microvesicles produced by the NK-92 natural killer cell line
Authors: Korenevsky A. V. , Shcherbitskaia A. D. , Berezkina M. E. , Markova K. L. , Alexandrova E. P. , Balabas O. A. , Selkov S. A. , Sokolov D. I. 
Published: August 2020

Extracellular vesicles that are shed from the plasma membrane contain a wide range of molecules, among which are proteins, lipids, nucleic acids, and sugars. The cytotoxic proteins of natural killer cells play a key role in the implementation of their cytolytic functions. One of the important steps in understanding the distant communication of cells is the determination of the proteome of microvesicles. This study was aimed at the protein profiling of the microvesicles produced by the NK-92 natural killer cell line. 986 proteins with a variety of functions were identified in the lysate of microvesicles using the MALDI-TOF mass spectrometric analysis. With automated methods of functional analysis applied, it has been shown that the largest protein groups are hypothetical proteins, proteins with unknown functions, and domains. The most representative groups are also comprised by transcription regulators; intracellular signaling proteins; RNA translation, transcription, processing, and utilization regulators; receptors; protein processing and proteolysis regulators; amino acid metabolism enzymes, as well as transport proteins and transport regulators. Minor functional groups are represented by vitamins and mineral metabolism enzymes, membrane and microdomain-forming proteins, hormones, hemostatic regulators, regulators of sensory systems, specific mitochondrial and Golgi apparatus proteins, and extracellular signaling proteins. An intermediate position is occupied by various functional groups, including cytoskeleton and motor proteins; proteins of centrioles; ion channels and their regulators; proteins of the ubiquitin-proteasome pathway of protein degradation; lipid, steroid, and fatty acid metabolism enzymes; nucleic acid base and carbohydrate metabolism enzymes, as well as energy metabolism enzymes and other proteins involved in intermediate metabolism; proteins of the immune response and inflammation; antigens and histocompatibility proteins; cytokines and growth factors; regulators of apoptosis, autophagy, endocytosis, and exocytosis; regulators of the cell cycle and division; regulators of proliferation, cell differentiation, and morphogenesis; regulators of cell adhesion and matrix metabolism; nuclear transport proteins; transposition proteins; DNA replication and repair proteins, as well as inactive proteins. The data obtained expand the existing knowledge of the distant communication of cells and indicate new mechanisms of interaction between natural killer and target cells.
ANALISIS KOMPETENSI KEPRIBADIAN GURU SEKOLAH DASAR GUGUS VII KECAMATAN TAMPAN KOTA PEKANBARU
Authors: Yosi Ana , Kurniaman Otang , Syahrilfuddin Syahrilfuddin 
Published: August 2020

Abstract: Guru yang berkualitas harus memiliki kompetensi dalam menjalankan tugasnya, kompetensi yang dimaksud adalah kemampuan yang dimiliki untuk menjalankan tugas atau pekerjaan yang didasari oleh pengetahuan, keterampilan, sikap, dan kepribadian yang sesuai dengan standar yang telah ditentukan. Guru juga wajib memiliki kompetensi kepribadian sesuai dengan Permendiknas nomor 16 tahun 2007 tentang standar kompetensi kepribadian guru SD/MI. Penelitian ini bertujuan untuk mengetahui kompetensi kepibadian guru Sekolah Dasar gugusVII kecamatan Tampan kota Pekanbaru. Penelitian ini merupakan penelitian kuantitatif deskriptif, metode pengumpulan data menggunakan kuesioner sebagai instrumen untuk memperoleh data kompetensi kepribadian guru Sekolah Dasar. Hasil penelitian menunjukkan bahwa pada kompetensi bertindak sesuai dengan norma agama, hukum, sosial, dan kebudayaan nasional Indonesia dengan persentase 73,84%; Kompetensi menampilkan diri sebagai pribadi yang jujur, berakhlak mulia, dan teladan bagi peserta didik dan masyarakat dengan persentase 70,91%; Kompetensi menampilkan diri sebagai pribadi yang mantap, stabil, dewasa, arif, dan berwibawa dengan persentase 75,57%; Kompetensi menunjukkan etos kerja, tanggung jawab yang tinggi, rasa bangga menjadi guru, dan rasa percaya diri dengan persentase 69,23%; Kompetensi menjunjung tinggi kode etik profesi guru dengan persentase 73,74%. Kata Kunci : Kompetensi, Kepribadian.
An Analysis of the Relationship between Students’ Scientific Attitude and Students’ Learning Style in Junior High School
Authors: Nugraha Ikmanda , Putri Nabilah Kinanti , Sholihin Hayat 
Published: August 2020

The objectives of this study were to profile the relationship of scientific attitude level and learning style preference among junior high school students in Bandung. This study utilized a survey research design with a total sample size of 110 students. A scientific attitude questionnaire and a visual, auditory, and kinesthetic (VAK) learning style inventory were administered in this study. The questionnaire measures five aspects of scientific attitude, specifically rationality, curiosity, open-mindedness, aversion to superstition, and objectivity. The VAK learning style inventory evaluates the preferred means of receiving sensory information. The scientific attitude questionnaire provided consistent results, as indicated by its reliability coefficient (0.896). The results show that junior high school students have an average level of scientific attitude and generally prefer a kinesthetic learning style. There was a medium relationship between scientific attitude and learning style among the students (Cramer’s V coefficient = 0.239). It is concluded that learning style must be considered in implementing a science lesson, especially in the Indonesian context.
Evaluation of the Science Laboratory Applications Course in a Pre-service Primary School Teacher Curriculum
Authors: Altunova Nebi , Artun Hüseyin 
Published: August 2020

In this study, the Science Laboratory Applications (SLA) course given in a department of Elementary School Teaching in Turkey was evaluated for effectiveness. A triangulation research design, with mixed methods, was employed based on research data collected via a semi-structured interview form, a Science Experiments Evaluation Rubric (SEER) developed by the researchers, and the researchers’ diary notes. The study group included 66 preservice teachers in their second year of study. To select the participants, a maximum variation sampling method was used with the qualitative interviews. The SEER scores were analyzed using the packaged software of SPSS, while interview data were evaluated using content analysis, and descriptive analysis was applied to the researcher’s diary notes. The quantitative and qualitative results obtained in the study revealed that preservice teachers achieved the course outcomes as well as the objectives of the curriculum. Based on these results, several suggestions are put forward for future researchers and practitioners.Keywords Elementary school preservice teacher, curriculum evaluation, course of science laboratory applications
Predictors of Mortality and Associated Lactate Trends in Cardiogenic Shock Patients Treated with Impella® Placement - A Single Center Experience
Authors: Ji Yong , Desai Amar , Fraser Gary E. , Narasimha Deepika , Abudayyeh Islam , Jutzy Kenneth R. , Hilliard Anthony A. 
Published: August 2020

Background: The Impella® devices have increasingly become a desired treatment option for cardiogenic shock (CS) as demonstrated by studies analyzing real-world use of hemodynamic support devices. However, data regarding outcomes after Impella® device implant and optimal timing of device placement remains scarce. This study investigates prognostic factors including serial lactate levels in CS patients treated with Impella®.Methods: This retrospective study reviewed 76 consecutive patients diagnosed with CS supported with Impella® at a large, tertiary-care university medical center. Clinical variables and outcomes examined include co-morbidities, pre- and post-procedural lactate levels, and mortality.Results: Of the 76 patients requiring an Impella®, 70% of patients survived to hospital discharge. Those who died post-device implant had a higher prevalence of hyperlipidemia (HLD), chronic kidney disease (CKD), and more likely to require multiple (>1) vasopressors. The mean pre-procedural lactate levels were significantly higher (5.86 +/- 5.11 vs 2.16 +/- 1.50, p = 0.01) in the population who died, along with the change in lactate levels (1.90 +/- 2.56 vs -0.40 +/- 1.73, p=0.04). Those who died within 24 hours of implant showed a trend toward higher mean pre-procedural lactate levels (8.46 +/- 6.00 vs 3.86 +/- 3.31, p = 0.12).Conclusions : Higher pre-procedural lactate levels, HLD, CKD, and increased vasopressor requirement were predictive of increased mortality in CS patients post-Impella® placement, especially within 24 hours of implant. Through serial lactate measurements, we demonstrated favorable outcomes in patients with early stabilization or greater lowering of post-procedural lactate levels suggestive of improved end organ perfusion.
An Asymptomatic Left Ventricular Pseudoaneurysm found incidentally at 12 months post Myocardial Infarction: Case Report and Review of the Literature
Authors: Brooks Christian , Cooke Heather 
Published: August 2020

Highlights: Left ventricular pseudoaneurysms are a rare mechanical complication of myocardial infarction. If found acutely following infarction (within 2 weeks, with some advocating up to 3 months), surgical repair is recommended due to their high risk of rupture.Whilst associated with chest pain, dyspnoea and heart failure, some individuals are asymptomatic, with the diagnosis made incidentally on routine follow-up often months to years post infarction. Less is known about the natural history of these chronic pseudoaneurysms, with concerns around their propensity to rupture perhaps less than the mortality risk of surgical repair.We present the case of a 70 year-old asymptomatic man who was found to have a 1.6cm left ventricular pseudoaneurysm found incidentally on routine transthoracic echocardiogram at 12-months post posterior myocardial infarction.The consensus opinion of our institution's multi-disciplinary team regarding further management of this patient, with reference to the current limited data on chronic pseudoaneurysms, will be discussed.
APROXIMACIÓN CRITICA AL CONFLICTO ARMADO EN COLOMBIA: Normatividad Interna- el reto del post conflicto
Authors: Rodelo García Margarita 
Published: August 2020

Colombia en las últimas décadas ha sido un país marcado por la guerra y los constantes conflictos, después de la firma de la paz Colombia enfrenta diversos retos y la academia no puede estar lejos de realidad. Esta investigación pretende realizar un análisis sobre el conflicto armado en Colombia, pasando por el origen, causas, los conceptos básicos sobre el conflicto, la normatividad interna los mecanismos y garantías de las normas y finalmente los dar luces sobre los retos de post-conflicto. Esta investigación se realizó con una metodología analítica sistemática, permitiendo analizar el conflicto armado en Colombia desde su origen hasta dar una mirada al post conflicto y sus retos, permitiendo dar unas conclusiones generales. La técnica ultimada es la interpretación y análisis de documentos escritos, la utilización de nuevas tecnologías, bibliotecas, red de internet y bases de datos.
Epidemiological study of cervical spine injury in a tertiary care center in South India
Authors: Asher Prasanth , Joseph Jijo Joseph , Pendro Varun Singh , Peethambaran Anilkumar , Prabhakar Rajmohan Bhanu 
Published: August 2020

Background: Cervical spine injuries, according to severity can leave victims with long standing neck pain or varying degrees of weaknesses. The purpose of this study is to determine the epidemiological pattern of cervical spine injury in our hospital so that comparison may be made with other institutions and guidance regarding management may be formulated for the betterment of patients.Methods: This cross-sectional longitudinal study was conducted in Government Medical College, Thiruvananthapuram and included all patients admitted with clinical or radiological evidence of cervical spine injury, over a period of three months. Semi-structured questionnaire was used to collect socio demographic data and details regarding mechanism of injury. Data was analyzed using SPSS.Results: Out of 452 patients enrolled, 69.7% were males and 30.3% were females. Patients were the most commonly between 30-60 years of age (52.4%). Majority (56.1%) had hospital stays lasting less than 10 days. Most common mechanism of injury was road traffic accidents (46.6%). Neck pain was the most common symptom and cervical spine straightening was the most common radiological abnormality. The severity of injuries was more severe in patients who were not restrained by seat belt or using a helmet.Conclusion: Road traffic accidents are the most common cause for cervical spine injuries and majority of patients required only symptomatic care.
Unmet Need Cause Factors in Lampung Timur District
Authors: Maydiantoro Albet , Nizar Moh. 
Published: August 2020

The problem of unmet need indicates a gap between the purpose of female reproduction and their perceptual behavior. This means that in one hand, women have a desire to avoid pregnancy; on the other hand, they do not take precautionary measures. Therefore, decrease on the percentage of the unmet need results on the significant number of contraception prevalence. Conversely, the high unmet need will be a problem for the government, not only causing the rapid increase in population but also affecting the high AKI (Maternal Mortality Rate).This research employed a descriptive method, describing the cause of Unfulfilled Pair Age (PUS) in the needs of family planning services in Eastern Lampung regency. As a consequence, all problems or causes of unmet need can be addressed by analyzing the data. For this study, research population has several criteria: first, mothers or married women who do not want to be pregnant again; second, they do not want to have another baby or they want to delay their pregnancy without using any contraception when data was collected. However, this study does not consider how many children they have, how old the latest child and the birth distance. The sample of this study was 336 people who are mothers or women in the status of unmet need. The findings suggest that factors for causing unmet need in East Lampung regency are caused by seven main factors and twelve specific factors. The seven factors are: first is the side effect of the use of contraceptive including obesity, bleeding and irregular menstrual cycles. Second is the cultural factor, including the desire to have male and female children. Third is wives’ perception including the impotent husband, fear of and away from their husband. Fourth is the health factor including, having high blood disease and cervical cancer and cysts. Fifth is the prohibition of husbands in the use of contraceptives. Sixth is religious and cultural prohibition such as considering the born babies is a gift from God, so there is no need to inhibit the birth. Seventh is behavioral factor such as laziness to use contraception.
Hemophagocytic Lymphohistiocytosis Syndrome As Presenting Sign For Acute Monocytic Leukaemia- A Case Report.
Authors: Sahaf Levin Gal , Ayada Gida , Yeshurun Moshe , Rogach Oleg , Lev Shaul 
Published: August 2020

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare aggressive syndrome of excessive immune activation. Clinical manifestations of this syndrome mimic various other clinical conditions making the diagnosis harder to achieve. These manifestations are believed to be a result of cytokine storm which leads, eventually, to a multi-organ failure and eventually death. The latter two might be prevented if HLH was diagnosed early.
HLH is classified into primary consist of monogenic disorders and secondary occurs as a complication in various settings such as infection, autoimmune disease, and malignancy.
In hematologic malignancies, HLH is classically associated with specific entities, mainly, lymphoma or induced by treatment-related infections. Acute myeloid leukemia, on the other hand, is less common trigger with only few case reports.

Case presentation: An 83-years-old, 5 years free of transitional cell man, presented with unstable atrial fibrillation was intubated and shortly after that he developed a multi-organ failure. Bicytopenia and a high level of ferritin aroused a clinical suspicion of HLH syndrome.
Further evaluation revealed high levels of soluble interleukin 2 receptors and no activity of natural killers cells. A bone marrow was performed and it did not show phagocytosis, however, acute myeloid leukemia (AML) was diagnosed. AML was suggested to be associated with chemotherapy that our patient received 5 years earlier.

Conclusion: Hemophagocytic lymphohistiocytosis can be present as a multi-organ failure requiring a high index of suspicion. Chemotherapy related-AML can be a trigger for HLH.