bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family influence and firm performance: the mediating role of stewardship
Authors: Afonso Alves Catarina , Matias Gama Ana Paula , Augusto Mário 
Published: December 2020

PurposeThis study examines how stewardship might mediate the influence of family ownership on firm financial performance. The authors argue that differences in financial performance may reflect not only the family's influence but also the prevalence of a stewardship-oriented culture, across varying degrees of family influence.Design/methodology/approachThe measure of family influence uses the F-PEC scale: family [F], power [P], experience [E] and culture [C]. It supports cross-firm comparisons of different levels of family influence. To capture the multidimensional nature of family influence, this study uses structural equation modelling and measures the meditating effects of stewardship.FindingsThe results reveal a mediating effect of stewardship; family firms achieve better performance when they take advantage of and encourage stewardship attitudes among owners and leaders. Factors associated with stewardship behaviour, including stewardship motivation and stewardship culture, help explain why some family firms perform better than others.Practical implicationsWhen analysing the behaviour of family firms, interested entrepreneurs, managers and consultants should acknowledge that the family's influence entails both financial and emotional capital. The survival of the family businesses depends on balancing these aspects.Originality/valueIn response to calls for research into mediators of the complex relationship between family influence and firm outcomes, this study provides a novel explanation for performance-maximizing behaviours by organizations, in which pro-organizational attitudes coexist with self-serving motives.
Social capital and knowledge integration in interdisciplinary research teams: a multilevel analysis
Authors: Zhang Xueyan , Wang Xiaohong , Zhao Wei 
Published: December 2020

PurposeEffective knowledge integration is vital for decision making in interdisciplinary research (IDR) teams. However, there is a lack of knowledge about the antecedents of knowledge integration. This study aims to examine how social capital at different levels and their interaction influences knowledge integration in IDR teams. Specifically, this study explores the moderating role of team social capital in the relationship between individual social capital and knowledge integration.Design/methodology/approachA survey on 346 individuals from 46 IDR teams in a research university in China is conducted. A multilevel analysis of the hierarchical linear model is used to process the sociometric data.FindingsResults reveal that team social capital interacts with individual social capital by influencing knowledge integration. At the individual level, tie strength and structural equivalence have a positive influence on knowledge integration. There is an inverted U-shaped relationship between betweenness centrality and knowledge integration. Furthermore, team cohesion negatively moderates the positive effect of tie strength and structural equivalence on knowledge integration. No support is found for the moderating role of team cohesion on the effect of betweenness centrality.Originality/valueFirst, different from previous research on social capital at single levels, this study links the individual-level and the team-level views to explore the effects of social capital on knowledge integration. Second, this study enriches research on inducing factors of knowledge integration. Third, this study extends social capital research and knowledge integration research to the IDR team context.
Relaxed Bodies and Comfortable Clothes: Reframing Masculinity in Post‐War Australia
Authors: Cramer Lorinda 
Published: December 2020

ABSTRACTAs Australia's Second World War servicemen began returning home, many anticipated the pleasure of stepping out of their uniforms for the last time. Yet scholarship on the role clothing played in repatriation and post‐war rehabilitation in Australia remains scarce. Exploring the post‐war swing towards sportswear, the article considers the growing idea of relaxed bodies and the language of comfort that underpinned it. It argues that being attentive to men's dress allows us to engage with a reframing of attractive, able, white, heterosexual bodies that combined two icons of Australian masculinity – the Anzac and the athlete – into a more relaxed vision of manliness.
Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging
Authors: de Lucia Claudio , Piedepalumbo Michela , Wang Lu , Carnevale Neto Fausto , Raftery Daniel , Gao Erhe , Praticò Domenico , Promislow Daniel E. L. , Koch Walter J. 
Published: December 2020

AbstractBackgroundHeart disease is a frequent cause of hospitalization and mortality for elderly patients. A common feature of both heart disease and aging itself is the involvement of metabolic organ alterations ultimately leading to changes in circulating metabolite levels. However, the specific contribution of aging and ischemic injury to the metabolic dysregulation occurring in older adults with ischemic heart disease is still unknown.AimTo evaluate the effects of aging and ischemia/reperfusion (I/R) injury on plasma metabolomic profiling in mice.MethodsYoung and aged mice were subjected to a minimally invasive model of I/R injury or sham operation. Complete evaluation of cardiac function and untargeted plasma metabolomics analysis were performed.ResultsWe confirmed that aged mice from the sham group had impaired cardiac function and augmented left ventricular (LV) dimensions compared to young sham‐operated mice. Further, we found that ischemic injury did not drastically reduce LV systolic/diastolic function and dyssynchrony in aged compared to young mice. Using an untargeted metabolomics approach focused on aqueous metabolites, we found that ischemic injury does not affect the plasma metabolomic profile either in young or old mice. Our data also demonstrate that age significantly affects circulating metabolite levels (predominantly amino acids, phospholipids and organic acids) and perturbs several pathways involved in amino acid, glucid and nucleic acid metabolism as well as pyridoxal‐5′‐phosphate salvage pathway in both sham and ischemic mice.ConclusionsOur approach increases our understanding of age‐associated plasma metabolomic signatures in mice with and without heart disease excluding confounding factors related to metabolic comorbidities.
Microinduction of Buprenorphine/Naloxone: A Review of the Literature
Authors: Ahmed Saeed , Bhivandkar Siddhi , Lonergan Brady B. , Suzuki Joji 
Published: December 2020

Background and ObjectivesBuprenorphine's high‐binding affinity as a partial µ‐opioid agonist displaces preexisting full agonists causing precipitated withdrawal, which requires most individuals starting buprenorphine to endure moderate withdrawal prior to induction to avoid precipitated withdrawal. A novel approach called microinduction has emerged to remove this prerequisite. Our aim is to review the literature on these alternative approaches.MethodsUsing keywords including buprenorphine, buprenorphine/naloxone, transdermal buprenorphine, suboxone, microinduction, microdosing, rapid induction, buprenorphine‐dosing protocol, the authors searched PubMed/Medline, EMBASE, PsycINFO, PsychARTICLES, and Scopus databases from the date of inception through April 30, 2020, which yielded 1726 results, which, in turn, after manual exclusion for irrelevant content and publication in languages other than English, generated a total of 18 papers.ResultsOn the basis of 18 papers included in this review, 63 patients were successfully transitioned to buprenorphine using different microdosing techniques, primarily in the inpatient setting. From the available data, patients were transitioned from a variety of opioids over a range of dosing without significant withdrawal, and initial doses ranged most frequently from 0.2 to 0.5 mg. While the timeframe for the various schedules ranged from 3 to 112 days, most transitioned over a period of 4 to 8 days, and most participants completed the cross titration at 8 to 16 mg.Discussion and ConclusionsThe growing literature demonstrates some initial promise for alternative induction models, specifically targeting patients averse to withdrawal, patients prescribed opioids for chronic pain, patients on high‐dose methadone, and patients using illicit or pharmaceutical fentanyl.Scientific SignificanceThis manuscript provides a review of the existing literature to help clinicians better understand the approaches to microdosing of buprenorphine in various clinical settings and populations. (Am J Addict 2020;00:00–00)
A Healthcare System‐Level Intervention to Increase Naloxone Availability for Patients With Opioid Prescriptions
Authors: Siff Jonathan E. , Margolius David , Papp Joan , Boulanger Bernard , Watts Brook 
Published: December 2020

Background and ObjectivesNational guidelines recommend prescribing naloxone to patients receiving chronic opioids. However, provider adherence to naloxone co‐prescribing best practices is poor and knowledge gaps for improvement efforts are large. As part of a system‐wide quality improvement intervention to improve opioid safety, we sought to improve access to naloxone for patients with opioid prescriptions.MethodsA prompt for naloxone co‐prescribing was implemented in the electronic health record. Baseline data and data after implementation were collected for naloxone co‐prescribing and fill rates on naloxone prescriptions s (n = 9122 pre, 8368 post).ResultsIn the 9 months following the implementation of the electronic prompt, the total number of naloxone prescriptions increased more than 15‐fold. Patients prescribed naloxone filled their naloxone prescriptions similarly (42%) before and after the prompt implementation, resulting in a marked increase in the absolute number of patients with access to naloxone. Patient fill rates varied by clinical area (33% emergency medicine to 47% general medicine).Conclusion and Scientific SignificanceAn electronic prompt, encouraging providers to prescribe naloxone to at‐risk patients led to a marked increase in the percentage of patients with an active naloxone prescription. The availability of naloxone in communities saves lives and this study is the first to demonstrate an intervention, which led to increased naloxone prescribing and reported on actual pharmacy fills of naloxone when co‐prescribed with opioids. (Am J Addict 2020;00:00–00)
Thinking about Government Authority: Constitutional Rules and Political Context in Citizens’ Assessments of Judicial, Legislative, and Executive Action
Authors: Braman Eileen 
Published: December 2020

AbstractThis study explores how citizens think about the appropriate exercise of authority across the branches of government. Three similarly designed experiments conducted on national samples reveal that what individuals are told about compliance with decision‐making rules matters across institutions, but so does the political context in which officials are acting. Participants’ policy preferences about the issues that are the subject of government action are particularly important in such assessments. Evidence suggests that feelings about President Trump and participants’ policy views are more important in assessments of the appropriateness of unilateral action than they were during the Obama administration; findings also suggest that what participants are told about President Trump's compliance with rules is less important. This could reflect an erosion in the importance of constitutional norms in citizens’ assessments of executive authority, but other explanations specific to the inquiry are also discussed.
Optic nerve sheath decompression saves sight in severe papilloedema: results from 81 eyes in 56 patients with pseudotumor cerebri
Authors: Söylev Bajin Meltem , Durmaz Engin Ceren , Yaman Aylin , Ayhan Ziya , Gökçay Figen , Çelebisoy Neşe , Men Süleyman , Akdal Gülden , Halmágyi Gábor Michael 
Published: December 2020

AbstractPurposeTo report the outcome of optic nerve sheath decompression (ONSD) for papilloedema in a teaching hospital in western Turkey.MethodsThe charts of 56 patients who had ONSD surgery between April 2007 and September 2019 were collated; and a total of 81 operated and 31 fellow eyes were included. Pre‐ and postoperative ophthalmologic examination including best‐corrected visual acuity (BCVA), colour vision (CV), visual field (VF) analysis, fundoscopic examination and demographic and medical characteristics of the patients were noted and outcomes after surgery were investigated.ResultsOf all study eyes, 49 (43.7%) eyes had BCVA 0.2 or less and 62 (55.3%) eyes had mean deviation (MD) below – 20.0 dB. 62 (55.3%) eyes had Frisen grade 4 or 5 papilloedema. Almost half of the eyes had severe vision loss. After ONSD, BCVA, CV and MD in both operated and fellow non‐operated eyes improved significantly (p < 0.001, p = 0.009 and p < 0.001 for operated, p < 0.001, p = 0.007 and p < 0.001 for fellow eyes, respectively). Earlier surgery and higher cerebrospinal fluid opening pressure were related to better outcomes. None of the patients had major operative complications.ConclusionOptic nerve sheath decompression can safely improve vision not only of the operated but also of the non‐operated eye, even in cases with severe vision loss from severe bilateral papilloedema. Regardless of initial VA and VF, patients may benefit from ONSD; the earlier it is done the more likely the better outcome.
Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex
Authors: Hu Junda , Xu Yan , Bachmann Sebastian , Mutig Kerim 
Published: December 2020

AbstractAimThe use of calcineurin inhibitors such as cyclosporine A (CsA) for immunosuppression after solid organ transplantation is commonly limited by renal side effects. CsA‐induced deterioration of glomerular filtration rate and sodium retention may be related to juxtaglomerular dysregulation as a result of suppressed cyclooxygenase 2 (COX‐2) and stimulated renin biosynthesis. We tested whether CsA‐induced COX‐2 suppression is caused by hyperactive renin‐angiotensin system (RAS) and whether RAS inhibition may alleviate the related side effects.MethodsRats received CsA, the RAS inhibitor candesartan, or the COX‐2 inhibitor celecoxib acutely (3 days) or chronically (3 weeks). Molecular pathways mediating effects of CsA and RAS on COX‐2 were studied in cultured macula densa cells.ResultsPharmacological or siRNA‐mediated calcineurin inhibition in cultured cells enhanced COX‐2 expression via p38 mitogen‐activated protein kinase and NF‐kB signalling, whereas angiotensin II abolished these effects. Acute and chronic CsA administration to rats led to RAS activation along with reduced cortical COX‐2 expression, creatinine clearance and fractional sodium excretion. Evaluation of major distal salt transporters, NKCC2 and NCC, showed increased levels of their activating phosphorylation upon CsA. Concomitant candesartan treatment blunted these effects acutely and completely normalized the COX‐2 expression and renal functional parameters at long term. Celecoxib prevented the candesartan‐induced improvements of creatinine clearance and sodium excretion.ConclusionSuppression of juxtaglomerular COX‐2 upon CsA results from RAS activation, which overrides the cell‐autonomous, COX‐2‐stimulatory effects of calcineurin inhibition. Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX‐2‐dependent normalization of creatinine clearance and sodium excretion.
INHALEd nebulised unfractionated HEParin for the treatment of hospitalised patients with COVID‐19 (INHALE‐HEP): Protocol and statistical analysis plan for an investigator‐initiated international metatrial of randomised studies
Authors: van Haren Frank M.P. , Richardson Alice , Yoon Hwan‐Jin , Artigas Antonio , Laffey John G. , Dixon Barry , Smith Roger , Vilaseca Alicia B. , Barbera Ruben A. , Ismail Tarek I. , Mahrous Rabab S. , Badr Mohamed , De Nucci Gilberto , Sverdloff Carlos , van Loon Lex M. , Camprubi‐Rimblas Marta , Cosgrave David W. , Smoot Thomas L. , Staas Sabrina , Sann Khine , Sas Caitlin , Belani Anusha , Hillman Christopher , Shute Janis , Carroll Mary , Wilkinson Tom , Carroll Miles , Singh Dave , Page Clive 
Published: December 2020

AimsInhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale that warrants urgent investigation of its therapeutic potential in patients with COVID‐19. UFH has antiviral effects and prevents the SARS‐CoV‐2 virus' entry into mammalian cells. In addition, UFH has significant anti‐inflammatory and anticoagulant properties, which limit progression of lung injury and vascular pulmonary thrombosis.MethodsThe INHALEd nebulised unfractionated HEParin for the treatment of hospitalised patients with COVID‐19 (INHALE‐HEP) metatrial is a prospective individual patient data analysis of on‐going randomised controlled trials and early phase studies. Individual studies are being conducted in multiple countries. Participating studies randomise adult patients admitted to the hospital with confirmed SARS‐CoV‐2 infection, who do not require immediate mechanical ventilation, to inhaled nebulised UFH or standard care. All studies collect a minimum core dataset. The primary outcome for the metatrial is intubation (or death, for patients who died before intubation) at day 28. The secondary outcomes are oxygenation, clinical worsening and mortality, assessed in time‐to‐event analyses. Individual studies may have additional outcomes.AnalysisWe use a Bayesian approach to monitoring, followed by analysing individual patient data, outcomes and adverse events. All analyses will follow the intention‐to‐treat principle, considering all participants in the treatment group to which they were assigned, except for cases lost to follow‐up or withdrawn.Trial registration, ethics and disseminationThe metatrial is registered at ClinicalTrials.gov ID NCT04635241. Each contributing study is individually registered and has received approval of the relevant ethics committee or institutional review board. Results of this study will be shared with the World Health Organisation, published in scientific journals and presented at scientific meetings.
Midwifery knowledge of equitable and culturally safe maternity care for Aboriginal women
Authors: Marriott Rhonda , Reibel Tracy , Barrett Terri‐Lee , Bowen Angela , Bradshaw Sue , Kendall Sally , Kotz Jayne , Martin Tracy , Monterosso Leanne , Robinson Melanie 
Published: December 2020

AbstractBackgroundThe Birthing on Noongar Boodjar project (NHMRC Partnership Project #GNT1076873) investigated Australian Aboriginal women and midwives’ views of culturally safe care during childbearing. This paper reports on midwifery knowledge of Aboriginal women's cultural needs, their perceptions of health systems issues, and their ability to provide equitable and culturally safe care.MethodA qualitative study framed by an Indigenous methodology and methods which supported inductive, multilayered analyses and consensus‐driven interpretations for two clinical midwife data groups (n = 61) drawn from a larger project data set (n = 145) comprising Aboriginal women and midwives.FindingsMidwives demonstrated limited knowledge of Aboriginal women's cultural childbearing requirements, reported inadequate access to cultural education, substituted references to women‐centered care in the absence of culturally relevant knowledge and consistently expressed racialized assumptions. Factors identified by midwives as likely to influence the midwifery workforce enabling them to provide culturally safe care for Aboriginal women included more professional development focused on improving understandings of cultural birth practices and health system changes which create safer maternal health care environments for Aboriginal women.ConclusionsIndividual, workforce, and health systems issues impact midwives’ capability to meet Aboriginal women's cultural needs. An imperative exists for effective cultural education and improved professional accountability regarding Aboriginal women's perinatal requirements and significant changes in health systems to embed culturally safe woman‐centered care models as a means of addressing racism in health care.
Leaky salt: Pipe trails record the history of cross‐evaporite fluid escape in the northern Levant Basin, Eastern Mediterranean
Authors: Oppo Davide , Evans Sian , Iacopini David , Kabir S. M. Mainul , Maselli Vittorio , Jackson Christopher A.‐L. 
Published: December 2020

AbstractDespite salt being regarded as an extremely efficient, low‐permeability hydraulic seal, an increasing number of cross‐evaporite fluid escape features have been documented in salt‐bearing sedimentary basins. Because of this, it is clear that our understanding of how thick salt deposits impact fluid flow in sedimentary basins is incomplete. We here examine the causes and evolution of cross‐evaporite fluid escape in the northern Levant Basin, Eastern Mediterranean. High‐quality 3D seismic data offshore Lebanon image hundreds of supra‐salt fluid escape pipes distributed widely along the margin. The pipes consistently originate at the crest of prominent sub‐salt anticlines, where overlying salt is relatively thin. The fact the pipes crosscut the salt suggests that hydrofracturing occurred, permitting focused fluid flow. Sequential pipes from unique emission points are organized along trails that are several kilometres long, and which are progressively deformed due to basinward gravity gliding of salt and its overburden. Correlation of pipes in 12 trails suggests margin‐wide fluid escape started in the Late Pliocene/Early Pleistocene, coincident with a major phase of uplift of the Levant margin. We interpret that the consequent transfer of overpressure from the central basin area, in addition to gas exsolution from hydrocarbons already trapped in sub‐salt anticlines, triggered seal failure and cross‐evaporite fluid flow. We infer that other causes of fluid escape in the Eastern Mediterranean, such as subsurface pressure changes driven by sea‐level variations and salt deposition associated with the Messinian Salinity Crisis, played only a minor role in triggering cross‐evaporite fluid flow in the northern Levant Basin. Further phases of fluid escape are unique to each anticline and cannot be easily correlated across the margin. Therefore, despite a common initial cause, long‐term fluid escape proceeded according to structure‐specific characteristics, such as local dynamics of fluid migration and anticline geometry. Our work shows that the mechanisms triggering cross‐evaporite fluid flow in salt basins vary in time and space.
Primitive Object Grasping for Finger Motion Synthesis
Authors: Hwang Jae‐Pyung , Park Gangrae , Suh Il Hong , Kwon Taesoo 
Published: December 2020

AbstractWe developed a new framework to generate hand and finger grasping motions. The proposed framework provides online adaptation to the position and orientation of objects and can generate grasping motions even when the object shape differs from that used during motion capture. This is achieved by using a mesh model, which we call primitive object grasping (POG), to represent the object grasping motion. The POG model uses a mesh deformation algorithm that keeps the original shape of the mesh while adapting to varying constraints. These characteristics are beneficial for finger grasping motion synthesis that satisfies constraints for mimicking the motion capture sequence and the grasping points reflecting the shape of the object. We verify the adaptability of the proposed motion synthesizer according to its position/orientation and shape variations of different objects by using motion capture sequences for grasping primitive objects, namely, a sphere, a cylinder, and a box. In addition, a different grasp strategy called a three‐finger grasp is synthesized to validate the generality of the POG‐based synthesis framework.