bluuebunny/crossref_metadata_2025_split huggingface dataset:
Folding of Thick Origami Through Regionally Sandwiched Compliant Sheets
Authors: Butler Jared , Pehrson Nathan , Magleby Spencer 
Published: October 2019

Abstract
The regional sandwiching of compliant sheets (ReCS) technique presented in this work creates flat-foldable, rigid-foldable, and self-deploying thick origami-based mechanisms. Regional sandwiching of the compliant sheet is used to create mountain-valley assignments for each fold about a vertex, constraining motion to a single branch of folding. Strain energy in deflected flexible members is used to enable self-deployment. This work presents the methods to design origami-based mechanisms using the ReCS technique, including volume trimming at the vertex of the compliant sheet and of the panels used in the sandwich. Three physical models, a simple single fold mechanism, a degree-four vertex mechanism, and a full tessellation, are presented to demonstrate the ReCS technique using acrylic panels with spring and low-carbon steels. Consideration is given to the risk of yielding of the compliant sheet due to parasitic motion with possible mitigation of yielding by decreasing the thickness of the sheet.
Statistical Parametric Mapping as a Measure of Differences Between Limbs: Applications to Clinical Populations
Authors: Hughes-Oliver Cherice N. , Harrison Kathryn A. , Williams D.S. Blaise , Queen Robin M. 
Published: October 2019

In healthy individuals, symmetrical lower-extremity movement is often assumed and calculated using discrete points during various tasks. However, measuring overall movement patterns using methods such as statistical parametric mapping (SPM) may allow for better interpretation of human movement. This study demonstrated the ability of SPM to assess interlimb differences in lower-extremity movement during 2 example tasks: running and landing. Three-dimensional motion analysis was used to determine sagittal and frontal plane lower-extremity joint angles in (1) young and older individuals during running and (2) patients with anterior cruciate ligament reconstruction and uninjured control athletes during landing. Interlimb differences within each group were compared using SPM and paired t tests on peak discrete angles. No differences between limbs were found between young and older runners using SPM. Peak ankle eversion and plantar flexion angles differed between limbs in young and older runners. Sagittal plane hip angle varied between limbs in uninjured control athletes. Frontal plane ankle angle and sagittal plane knee and hip angles differed between limbs in patients with anterior cruciate ligament reconstruction using SPM and discrete analysis. These data suggest that SPM can be useful to determine clinically meaningful interlimb differences during running and landing in multiple populations.
The Test–Retest Reliability of Force Plate–Derived Parameters of the Countermovement Push-Up as a Power Assessment Tool
Authors: Parry Gemma N. , Herrington Lee C. , Horsley Ian G. 
Published: October 2019

Context: Muscular power output of the upper limb is a key aspect of athletic and sporting performance. Maximal power describes the ability to immediately produce power with maximal velocity at the point of release, impact, or takeoff, with research highlighting that the greater an athlete’s ability to produce maximal power, the greater the improvement in athletic performance. Despite the importance of upper-limb power for athletic performance, there is presently no gold-standard test for upper-limb force development performance. Objective: The aim of this study was to investigate the test–retest reliability of force plate–derived measures of the countermovement push-up in active males. Design: Test–retest design. Setting: Controlled laboratory. Participants: Physically active college athletes (age 24 [3] y, height 1.79 [0.08] m, body mass 81.7 [9.9] kg). Intervention: Subjects performed 3 repetitions of maximal effort countermovement push-up trials on Kistler force plates on 2 separate test occasions 7 days apart. Main Outcome Measures: Peak force, mean force, flight time, rate of force development, and impulse were analyzed from the force–time curve. Results: No significant differences between the 2 trial occasions were observed for any of the derived performance measures. Intraclass correlation coefficient and within-subject coefficient of variation calculations indicated performance measures to have moderate to very high reliability (intraclass correlation coefficient = .88–.98), coefficient of variation = 5.5%–14.1%). Smallest detectable difference for peak force (7.5%), mean force (8.6%), and rate of force development (11.2%) were small to moderate. Conclusion: Force platform–derived kinetic parameters of countermovement push-up are reliable measurements of power in college-level athletes.
Do Alternative Cooling Methods Have Effective Cooling Rates for Hyperthermia Compared With Previously Established CWI Cooling Rates?
Authors: Parker Kailin C. , Shelton Rachel R. , Lopez Rebecca M. 
Published: October 2019

Clinical Scenario: In the last few years, there have been several studies examining alternative cooling strategies in the treatment of exertional heat stroke (EHS). Morbidity and mortality with EHS are associated with how long the patient’s core body temperature remains above the critical threshold of 40.5°C. Although cold-water immersion (CWI) is the gold standard of treatment when cooling a patient with EHS, more recent alternative cooling techniques have been examined for use in settings where CWI may not be feasible (ie, remote locations). Clinical Question: Do alternative cooling methods have effective core body temperature cooling rates for hyperthermia compared with previously established CWI cooling rates? Summary of Key Findings: The authors searched for studies using alternative cooling methods to cool hyperthermic individuals. To be included, the studies needed a PEDro score ≥6 and a level of evidence ≥2. They found 9 studies related to our focused clinical question; of these, 5 studies met the inclusion criteria. The cooling rates for hand cooling, cold-water shower, and ice-sheet cooling were 0.03°C/min, 0.08°C/min, and 0.06°C/min, respectively, whereas the tarp-assisted cooling with oscillation (TACO) method was the only method that had an acceptable cooling rate (range 0.14–0.17°C/min). Clinical Bottom Line: When treating EHS, if CWI is not available, the tarp-assisted cooling method may be a reasonable alternative. Clinicians should not use cold shower, hand cooling, or ice-sheet cooling if better cooling methods are available. Clinicians should always use CWI when available. Strength of Recommendation: Five level 2 studies with PEDro scores ≥6 suggest the TACO method is the only alternative cooling method that decreases core body temperature at a similar, though slower, rate of CWI. Hand cooling, cold showering, and ice-sheet cooling do not decrease core body temperature at an appropriate rate and should not be used in EHS situations if a modality with a better cooling rate is available.
Injury Profile of Elite Male Young Soccer Players in a Spanish Professional Soccer Club: A Prospective Study During 4 Consecutive Seasons
Authors: Raya-González Javier , Suárez-Arrones Luis , Navandar Archit , Balsalobre-Fernández Carlos , Sáez de Villarreal Eduardo 
Published: October 2019

Context: As the number of injuries in young soccer players increases, an epidemiological study is the first step in improving preventive strategies. Objectives: To analyze the injury profile of a Spanish professional soccer club’s academy during 4 consecutive seasons and to examine the injury incidence across different chronological age groups. Design: Prospective cohort design. Setting: Aggregate injury and exposure data collected during 4 consecutive seasons. Participants: Three hundred nine elite male young soccer players. Main Outcomes Measures: Injuries that led to participation time missed from training and match play prospectively reported by medical or coaching staff of the club. Results: A total of 464 time-loss injuries were observed during this study period. The overall injury incidence was 2.93 injuries per 1000 hours, with higher incidence during matches than during training (10.16 vs 2.10 injuries/1000 h; rate ratio [RR] = 0.21; 95% confidence interval [CI], 0.17–0.25; P < .05), with the U14 age group presenting the lowest injury rate (2.39 injuries/1000 h; RR = 1.15–1.57; P < .05). In terms of injury severity, moderate injuries were the most frequent (1.42 injuries/1000 h). Muscle injuries were the most common type of injuries (57.7%; 2.75 injuries/1000 h; RR = 1.84–13.4; P < .05), and hamstrings (93/268) were the most affected muscle group (0.58 injuries/1000 h; RR = 1.58–2.91; P < .05). Injury incidence showed a seasonal variation as indicated by peaks in August and October. In matches, specifically, the match period between 75 and 90 minutes showed the highest injury incidence (10.29 injuries/1000 h; RR = 1.89–6.38; P < .01). Conclusions: The findings of this study suggest that specific preventive strategies must be implemented to try to reduce the injury incidence in Spanish elite young soccer players attending to the characteristics of each age group.
Gender Categorizations During Group Work in Physical Education
Authors: Koekoek Jeroen , Knoppers Annelies 
Published: October 2019

Purpose: To explore how the use of gender categorizations inform children’s preferences of working with others in physical education. Method: Draw, write, and tell procedures were used to elicit the thoughts and feelings of 42 children, across four schools, about their peers and working together in groups. The children, aged between 11 and 13 years, were distributed across 14 focus groups to talk about conditions in group work that they thought facilitated and inhibited their learning. Results: Two meta-themes—(a) classmates and friendships and (b) work intention and trust—emerged from the interview data about their preferences for the ways groups were constituted. The results indicated that these children created or constructed categories of their peers based on gender but using gender-neutral words. Conclusion: Their constructions of working with others in PE contributed to an implicit curriculum consisting of different expectations for the same gender and for other gender groups.
Interleukin-1α deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice
Authors: Almog Tal , Kandel Kfir Michal , Levkovich Hana , Shlomai Gadi , Barshack Iris , Stienstra Rinke , Lustig Yaniv , Leikin Frenkel Alicia , Harari Ayelet , Bujanover Yoram , Apte Roni , Shaish Aviv , Harats Dror , Kamari Yehuda 
Published: October 2019

ObjectiveWhile extensive research revealed that interleukin (IL)-1β contributes to insulin resistance (IR) development, the role of IL-1α in obesity and IR was scarcely studied. Using control, whole body IL-1α knockout (KO) or myeloid-cell-specific IL-1α-deficient mice, we tested the hypothesis that IL-1α deficiency would protect against high-fat diet (HFD)-induced obesity and its metabolic consequences.Research design and methodsTo induce obesity and IR, control and IL-1α KO mice were given either chow or HFD for 16 weeks. Glucose tolerance test was performed at 10 and 15 weeks, representing early and progressive stages of glucose intolerance, respectively. Liver and epididymal white adipose tissue (eWAT) samples were analyzed for general morphology and adipocyte size. Plasma levels of adiponectin, insulin, total cholesterol and triglyceride (TG), lipoprotein profile as well as hepatic lipids were analyzed. Expression of lipid and inflammation-related genes in liver and eWAT was analyzed. Primary mouse hepatocytes isolated from control mice were treated either with dimethyl sulfoxide (DMSO) (control) or 20 ng/mL recombinant IL-1α for 24 hours and subjected to gene expression analysis.ResultsAlthough total body weight gain was similar, IL-1α KO mice showed reduced adiposity and were completely protected from HFD-induced glucose intolerance. In addition, plasma total cholesterol and TG levels were lower and HFD-induced accumulation of liver TGs was completely inhibited in IL-1α KO compared with control mice. Expression of stearoyl-CoA desaturase1 (SCD1), fatty acid synthase (FASN), elongation of long-chain fatty acids family member 6 (ELOVL6), acetyl-CoA carboxylase (ACC), key enzymes that promote de-novo lipogenesis, was lower in livers of IL-1α KO mice. Treatment with recombinant IL-1α elevated the expression of ELOVL6 and FASN in mouse primary hepatocytes. Finally, mice with myeloid-cell-specific deletion of IL-1α did not show reduced adiposity and improved glucose tolerance.ConclusionsWe demonstrate a novel role of IL-1α in promoting adiposity, obesity-induced glucose intolerance and liver TG accumulation and suggest that IL-1α blockade could be used for treatment of obesity and its metabolic consequences.
Development and validation of a questionnaire for the assessment of the knowledge, management and reporting ADR in paediatrics by healthcare teams (QUESA-P)
Authors: Tavares Sheilla S , Cruz Luciane N , Castro Juliana , Lopes Luciane Cruz 
Published: October 2019

ObjectiveWe aimed to develop and validate a new instrument called Questionnaire for the assessment of the knowledge, management and reporting ADR in Paediatrics by Healthcare teams (QUESA-P).DesignThis is a cross-sectional study.Settings and participantsTeams of healthcare professionals (HCP) that lead with pharmacological therapy in Paediatrician’s sector (Paediatric-HCP) in seven public hospitals in Brazil.OutcomeAn assessment of the knowledge and current management of ADR in Paediatric-HCP.MethodsWe developed and validated QUESA-P, using a standardised procedure which included item development and psychometric prevalidation using Cronbach’s Alpha, item-total correlation and test–retest validity for internal consistency and reliability. External criterion was used as criterion validation (the instrument was applied to the focus group expert vs focus group team of Paediatric-HCP in hospitals). The focus group of experts who participated in psychometrics was asked to respond to the QUESA-P twice in order to assess test-retest reliability. The content validity of the initial questionnaire was assessed by the Delphi method and pilot test. Subsequently, we made minor revisions and finalized the QUESA-PResultsSelection of domains and facets were based on literature review made in duplicate by authors. Content validity was done by trial of different examiners (panellists, n=16), conducting analysis through Delphi method (three rounds). The QUESA-P was constructed with three domains. The intraclass correlations (0.80) and the Cronbach’s alpha coefficient (0.82), indicated adequate test–retest reliability and internal consistency for each domain. The application of the QUESA to 61 Paediatric-HCP in hospital resulted in lower mean score of 42.1 ± 3.4 in all domains when compared with expert teams (n= 46) 48.2 ± 3.7 (p <0.001) indicating that the instrument is valid to discriminate QUESA experts and Paediatric-HCP.ConclusionThe selected domains can be used to check weaknesses in the identification, management and reporting of suspected ADR by Paediatric-HCP in Brazil.
Regional variation in primary care improvement strategies and policy: case studies that consider qualitative contextual data for performance measurement in three Canadian provinces
Authors: Martin-Misener Ruth , Wong Sabrina T , Johnston Sharon , Blackman Stephanie , Scott Catherine , Hogg William , Burge Fred , Grool Anne M , Campbell John L , Wuite Sara 
Published: October 2019

ObjectiveTo explore regional primary care improvement strategies that are potentially determinants of primary care performance.DesignMultiple comparative embedded case study.SettingThree regions in Canada: Fraser East, British Columbia; Eastern Ontario Health Unit, Ontario; Central Zone, Nova Scotia.Data sources(1) In-depth interviews with purposively selected key informants (eg, primary care decision-makers, physician leads, regulatory agencies) and focus groups with patients and clinicians (n=68 participants) and (2) published and grey literature (n=205 documents).Outcome measuresVariations in spread and uptake of primary care improvement strategies across the three study regions. NVivo (V.11) was used to manage data and perform content analysis to identify categories within and across cases. The coding structure was developed by researchers through iterative collaboration, using inductive and deductive processes.ResultsSix overarching primary care improvement strategies, differing in focus and spread, were implemented across the three study regions: interprofessional team-based approaches, provider skill mix expansion, physician groups and networks, information systems, remuneration and performance measurement and reporting infrastructure.ConclusionThe addition of information on regional improvement strategies to primary care performance reports could add important contextual insights into primary care performance results. This could help identify possible drivers of reported performance outcomes and levers for change in practice, regional and system-level settings.
Study protocol for a systematic review of evidence for digital interventions for comorbid excessive drinking and depression in community-dwelling populations
Authors: Schulte Bernd , Kaner Eileen F S , Beyer Fiona , Schmidt Christiane S , O'Donnell Amy 
Published: October 2019

IntroductionExcessive drinking and depression are frequently comorbid and make a substantial contribution to the global non-communicable disease burden. A range of effective interventions and treatments exist for either excessive drinking or depression alone, including a positive emerging evidence base for the use of digital interventions. Computerised and/or smartphone delivered advice could provide flexible, coordinated support for patients with comorbid excessive drinking and depression. However, to date, no systematic review of the evidence has been conducted focused on the effectiveness of digital interventions for this specific comorbid population. This systematic review will identify and evaluate the effectiveness of digital interventions for reducing comorbid excessive drinking and depression in community-dwelling populations.Methods and analysisWe will search MEDLINE, The Cochrane Library, CENTRAL, CINAHL, PsycINFO, ERIC and SCI from inception to end of July 2019 for randomised controlled trials that evaluate any personalised digital intervention for comorbid excessive drinking and depression and published in any language. Primary outcomes will be changes in quantity of alcohol consumed and depressive symptoms. Screening, data extraction and risk of bias assessment will be undertaken independently by two reviewers, with disagreements resolved through discussion. Meta-analytic methods will be used to synthesise the data collected relating to the primary outcomes of interest.Ethics and disseminationAs a systematic review, ethical approval is not needed. Findings will be published in peer-reviewed journals and presented at conferences.Trial registration numberCRD42019130134.
Primary care integration of sexual and reproductive health services for chlamydia testing across WHO-Europe: a systematic review
Authors: Quezada-Yamamoto Harumi , Dubois Elizabeth , Mastellos Nikolaos , Rawaf Salman 
Published: October 2019

ObjectiveTo identify current uptake of chlamydia testing (UCT) as a sexual and reproductive health service (SRHS) integrated in primary care settings of the WHO European region, with the aim to shape policy and quality of care.DesignSystematic review for studies published from January 2001 to May 2018 in any European language.Data sourcesOVID Medline, EMBASE, Maternal and Infant Care and Global Health.Eligibility criteriaPublished studies, which involved women or men, adolescents or adults, reporting a UCT indicator in a primary care within a WHO European region country. Study designs considered were: randomised control trials (RCTs), quasi-experimental, observational (eg, cohort, case–control, cross-sectional) and mixed-methods studies as well as case reports.Data extraction and synthesisTwo independent reviewers screened the sources and validated the selection process. The BRIGGS Critical Appraisal Checklist for Analytical Cross-Sectional Studies, the Mixed Methods Appraisal Tool 2011 and Critical Appraisal Skills Programme (CASP) checklists were considered for quality and risk of bias assessment.Results24 studies were finally included, of which 15 were cross-sectional, 4 cohort, 2 RCTs, 2 case–control studies and 1 mixed-methods study. A majority of the evidence cites the UK model, followed by the Netherlands, Denmark, Norway and Belgium only. Acceptability if offered test in primary healthcare (PHC) ranged from 55% to 81.4% in women and from 9.5% to 70.6% when both genders were reported together. Men may have a lower UCT compared with women. When both genders were reported together, the lowest acceptability was 9.5% in the Netherlands. Denmark presented the highest percentage of eligible people who tested in a PHC setting (87.3%).ConclusionsDifferent health systems may influence UCT in PHC. The regional use of a common testing rate indicator is suggested to homogenise reporting. There is very little evidence on integration of SRHS such as chlamydia testing in PHC and there are gaps between European countries.
Motivators and barriers to engagement with evidence-based practice among medical and dental trainees from the UK and Republic of Ireland: a national survey
Authors: Hong Bosun , O'Sullivan Eoin Daniel , Henein Christin , Jones Christopher Mark 
Published: October 2019

ObjectivesTo explore the extent to which doctors and dentists in training within the UK and Republic of Ireland (RoI) engage in and with evidence-based practice (EBP), and to identify motivators and barriers to them doing so.DesignAn observational, prepiloted web-based survey developed by a trainee-led focus group.SettingThe survey instrument was disseminated to doctors and dentists in training within the UK and RoI during June 2017 via social media and through deaneries, Royal Colleges and specialty-specific mailing lists.ParticipantsData from 243 trainees were analysed; 188 doctors from 31 specialties and 55 dentists from 9 specialties. Responses were received from trainees at all stages of postgraduate training though the overall response rate was low.Primary and secondary outcome measuresThe motivators and barriers to, and the extent of, trainee engagement with EBP.ResultsCronbach’s α was 0.83. Most trainees (87.6% (n=148) of doctors and 75.1% (n=39) of dentists) consulted the evidence base at least monthly, while 23.1% [n=39 doctors, 12 dentists] of both specialties did so daily. The two most commonly cited barriers to engagement with EBP for both doctors and dentists, respectively, were insufficient time (57.6% (n=95) and 45.1% (n=23)) and a tendency to follow departmental practice (40.6% (n=67) and 45.1% (n=23)). Key motivators for EBP included curiosity, following the example set by senior colleagues and a desire to avoid harm. Most trainees reported high levels of confidence interpreting evidence yet for 26.8% (n=45) of doctors and 36.5% (n=19) of dentists, medical hierarchy would impede them querying a colleague’s management plan based on their own reading of the evidence.ConclusionsTime, accepted departmental practice and the behaviour of senior clinicians all highly impact on trainee engagement with EBP. Given the low response rate, the extent to which these data represent the overall population is unclear.