bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender, Sex, and Trust in Government
Authors: McDermott Monika L. , Jones David R. 
Published: December 2020

AbstractAs Americans’ trust in their government—most specifically Congress—has declined over the past half century, it has become increasingly important to answer the question of who does or does not trust government and why. Trust research tends to take for granted that sex affects trust—most studies control for it—but results have been mixed. This could be because researchers have been looking at the wrong aspect of gender, relying on the traditional distinction of sex rather than an alternative—the non-sex-specific distinction of feminine personality traits. These traits are communal in nature, and as such, they may lead to higher levels of trust in government. This article analyzes the potential effect of femininity, demonstrating that feminine personalities are significantly more trusting of our governing institutions than nonfeminine personalities.
The application of in utero magnetic resonance imaging in the study of the metabolic and cardiovascular consequences of the developmental origins of health and disease
Authors: Giza Stephanie A. , Sethi Simran , Smith Lauren M. , Empey Mary-Ellen E. T. , Morris Lindsay E. , McKenzie Charles A. 
Published: December 2020

AbstractObserving fetal development in utero is vital to further the understanding of later-life diseases. Magnetic resonance imaging (MRI) offers a tool for obtaining a wealth of information about fetal growth, development, and programming not previously available using other methods. This review provides an overview of MRI techniques used to investigate the metabolic and cardiovascular consequences of the developmental origins of health and disease (DOHaD) hypothesis. These methods add to the understanding of the developing fetus by examining fetal growth and organ development, adipose tissue and body composition, fetal oximetry, placental microstructure, diffusion, perfusion, flow, and metabolism. MRI assessment of fetal growth, organ development, metabolism, and the amount of fetal adipose tissue could give early indicators of abnormal fetal development. Noninvasive fetal oximetry can accurately measure placental and fetal oxygenation, which improves current knowledge on placental function. Additionally, measuring deficiencies in the placenta’s transport of nutrients and oxygen is critical for optimizing treatment. Overall, the detailed structural and functional information provided by MRI is valuable in guiding future investigations of DOHaD.
Seed retention of grass weeds at wheat harvest in the Pacific Northwest
Authors: San Martín Carolina , Thorne Mark E. , Gourlie Jennifer A. , Lyon Drew J. , Barroso Judit 
Published: December 2020

AbstractHarvest weed seed control (HWSC) may control problematic weeds by decreasing contributions to the weed seedbank. However, HWSC practices will not be effective if plants have shed a great part of their seeds before harvest or if a low proportion of seed production is retained at a height that enables collection during harvest. The seed-shattering pattern of several weed species was evaluated over three growing seasons to determine their potential to be controlled with HWSC in the Pacific Northwest (PNW). The studied weed species were downy brome (Bromus tectorum L.), feral rye (Secale cereale L.), Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot], and rattail fescue [Vulpia myuros (L.) C.C. Gmel.]. Seed retention at harvest, seed production, and plant height differed among species, locations, and years. Environmental conditions influenced seed-shattering patterns, particularly the time plants started to shatter seeds and the rate of the shattering. Agronomic factors such as herbicide use, interrow space, or crop height/vigor also seemed to affect shattering patterns and seed production, but more specific studies must be conducted to determine their individual effects. Bromus tectorum, L. perenne ssp. multiflorum, and V. myuros had an average seed retention at harvest of less than 50%. In addition, the low seed retention height of V. myuros makes this species a poor candidate for HWSC. Secale cereale had average seed retention at harvest greater than 50%, and seed retention height was greater than 30 cm. The variability of seed retention in different species will make the efficacy of HWSC practices species and environment dependent in PNW winter wheat (Triticum aestivum L.) cropping systems. Harvesting the wheat crop as early as possible will be crucial to the success of HWSC.
Fates of Paleo‐Antarctic Bottom Water During the Early Eocene: Based on a Lagrangian Analysis of IPSL‐CM5A2 Climate Model Simulations
Authors: Zhang Yurui , Grima Nicolas , Huck Thierry 
Published: December 2020

AbstractBoth deepwater formation and the obduction processes converting dense deep water to lighter surface water are the engine for the global meridional overturning circulation (MOC). Their spatio‐temporal variations effectively modify the ocean circulation and related carbon cycle, which affects climate evolution throughout geological time. Using early‐Eocene bathymetry and enhanced atmospheric CO2 concentration, the IPSL‐CM5A2 climate model has simulated a well‐ventilated Southern Ocean associated with a strong anticlockwise MOC. To trace the fates of these paleo‐Antarctic Bottom Water (paleo‐AABW), we conducted Lagrangian analyses using these IPSL‐CM5A2 model results and tracking virtual particles released at the lower limb of the MOC, defined as an initial section at 60°S below 1,900 m depth. Diagnostic analysis of these particles trajectories reveals that most paleo‐AABW circulates back to the Southern Ocean through either the initial section (43%) or the section above (31%), the remaining (>25%) crossing the base of the mixed layer mostly in tropical regions (up to half). The majority of water parcels ending in the mixed layer experience negative density transformations, intensified in the upper 500 m and mostly occurring in tropical upwelling regions, with a spatial pattern consistent with the wind‐driven Ekman pumping, largely determined by the Eocene wind stress and continental geometry. In the same way as present‐day North Atlantic Deep Water upwells in the Southern Ocean, our results suggest that the strong tropical and equatorial upwelling during the Eocene provides an efficient pathway from the abyss to the surface, but at much higher temperature, with potential implications for the oceanic carbon cycle.
Water Smart Cities Increase Irrigation to Provide Cool Refuge in a Climate Crisis
Authors: Livesley Stephen J. , Marchionni Valentina , Cheung Pui Kwan , Daly Edoardo , Pataki Diane E. 
Published: December 2020

AbstractWater smart cities are increasing their use of irrigation and misting to cope with extreme heat and drought. This is being enabled by widespread use of rainwater tanks, stormwater capture and storage systems, and recycled sewage wastewater to irrigate street trees as well as private and public green spaces. These alternative water resources provide new options for cities to better withstand and function under extreme summer heatwave conditions with little or no impact on drinking water supplies. Small‐scale approaches to evaporatively cool urban animals, vegetation habitat, and people are showing initial success. However, ongoing testing and modeling are needed to understand the impacts of scaling up these interventions and to evaluate their cost‐effectiveness. We describe current innovations in irrigation of Australian cities to help policy development in other countries and cities experiencing similar climates with episodic summer heatwaves.
Dropstones in the Mar del Plata Canyon Area (SW Atlantic): Evidence for Provenance, Transport, Distribution, and Oceanographic Implications
Authors: Bozzano G. , Cerredo M. E. , Remesal M. , Steinmann L. , Hanebuth T. J. J. , Schwenk T. , Baqués M. , Hebbeln D. , Spoltore D. , Silvestri O. , Acevedo R. D. , Spiess V. , Violante R. A. , Kasten S. 
Published: December 2020

AbstractA variety of gravel‐ to cobble‐sized rocks, recovered from the Mar del Plata (MdP) Canyon area (Western South Atlantic at 38°S) and interpreted as ice‐rafted debris, represent the first evidence that large icebergs have floated in the Falkland (Malvinas) Current from the southern polar high latitudes far northward. Detailed petrographic analyses identified the Antarctic Peninsula, sub‐Antarctic islands in the Scotia Sea, and Tierra del Fuego as plausible source areas. The drift process could have started as early as at the beginning of the last deglaciation, according to an age obtained from a cold‐water coral fragment associated with one of the dropstones. At the end of the Last Glacial Maximum, large icebergs have been supplied to the Antarctic Circumpolar Current, captured by those ocean current branches that circumvent the Falkland (Malvinas) Islands and entered the Argentine Margin. When the iceberg fleets approached the Brazil‐Falkland (Malvinas) Confluence Zone with its steep latitudinal temperature gradient, the icebergs got oceanographically trapped and melted off rapidly. The sediment load sinking down to the seafloor formed a dropstone blanket particularly where the MdP Canyon had incised into the continental slope. Here, mass‐flow processes, induced by local slope instability, and along‐slope sediment resorting, due to the erosional effects of strong and persistent contouritic bottom currents, favored local enrichment in dropstones in the form of a loose, coarse sediment drape inside morphological depressions. The bottom current velocity would be locally strong enough to rework this sediment, leaving coarse rafted debris as a lag deposit.
Role of Pore‐Scale Disorder in Fluid Displacement: Experiments and Theoretical Model
Authors: Wu Dong‐Sheng , Hu Ran , Lan Tian , Chen Yi‐Feng 
Published: December 2020

AbstractThe flow of multiple immiscible fluids in disordered porous media is important in many natural processes and subsurface applications. The pore‐scale disorder affects the fluid invasion pathways significantly and induces the transitions of displacement patterns in porous media. Extensive studies focus on pattern transitions affected by disorder under quasistatic or dynamic conditions, but how the disorder controls the pattern transitions from capillary‐dominated regime to viscous‐dominated regime is not well understood. Here, we combine microfluidic experiments and theoretical analysis to investigate the role of disorder in fluid displacement. We perform drainage experiments with four different disorders under six flow rate conditions and show that increasing disorder destabilizes displacement fronts for all flow rates considered. Based on the scaling analysis of pore‐filling events, we propose a theoretical model that describes the pattern transitions from compact displacement to capillary to viscous fingering as functions of disorder and capillary number. The effects of disorder on both capillary and viscous forces are quantified within the theoretical model. The phase diagram predicted by this model agrees well with our experimental results. We further elucidate the role of disorder in fluid displacement via energy conversion and dissipation. We find that increasing disorder enhances the capillary instabilities and induces more energy dissipated in a capillary‐dominated regime, with the dissipation ratio increasing from 28.3% to 56.7%. Our work extends the classic phase diagram to consider the effect of disorder and provides a better understanding of the impact of the disorder on flow behaviors by energy dissipation.
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury
Authors: Li Xiang , Peng Zhiming , Long Lingli , Lu Xiaofang , Zhu Kai , Tuo Ying , Chen Ningning , Zhao Xiaoyang , Wang Le , Wan Yong 
Published: December 2020

AbstractTraditional therapeutic strategies for spinal cord injury (SCI) are insufficient to repair locomotor function because of the failure of axonal reconnection and neuronal regeneration in the injured central nervous system (CNS). Neural stem cell (NSC) transplantation has been considered a potential strategy and is generally feasible for repairing the neural circuit after SCI; however, the most formidable problem is that the neuronal differentiation rate of NSCs is quite limited. Therefore, it is essential to induce the neuronal differentiation of NSCs and improve the differentiation rate of NSCs in spinal cord repair. Our results demonstrate that both Wnt5a and miRNA200b-3p could promote NSC differentiation into neurons and that Wnt5a upregulated miRNA200b-3p expression through MAPK/JNK signaling to promote NSC differentiation into neurons. Wnt5a could reduce RhoA expression by upregulating miRNA200b-3p expression to inhibit activation of the RhoA/Rock signaling pathway, which has been reported to suppress neuronal differentiation. Overexpression of RhoA abolished the neurogenic capacity of Wnt5a and miRNA200b-3p. In vivo, miRNA200b-3p was critical for Wnt5a-induced NSC differentiation into neurons to promote motor functional and histological recovery after SCI by suppressing RhoA/Rock signaling. These findings provide more insight into SCI and help with the identification of novel treatment strategies.
Using intracellular plasmonics to characterize nanomorphology in human cells
Authors: Sohrabi Kashani Ahmad , Piekny Alisa , Packirisamy Muthukumaran 
Published: December 2020

AbstractDetermining the characteristics and localization of nanoparticles inside cells is crucial for nanomedicine design for cancer therapy. Hyperspectral imaging is a fast, straightforward, reliable, and accurate method to study the interactions of nanoparticles and intracellular components. With a hyperspectral image, we could collect spectral information consisting of thousands of pixels in a short time. Using hyperspectral images, in this work, we developed a label-free technique to detect nanoparticles in different regions of the cell. This technique is based on plasmonic shifts taking place during the interaction of nanoparticles with the surrounding medium. The unique optical properties of gold nanoparticles, localized surface plasmon resonance bands, are influenced by their microenvironment. The LSPR properties of nanoparticles, hence, could provide information on regions in which nanoparticles are distributed. To examine the potential of this technique for intracellular detection, we used three different types of gold nanoparticles: nanospheres, nanostars and Swarna Bhasma (SB), an Indian Ayurvedic/Sidha medicine, in A549 (human non-small cell lung cancer) and HepG2 (human hepatocellular carcinoma) cells. All three types of particles exhibited broader and longer bands once they were inside cells; however, their plasmonic shifts could change depending on the size and morphology of particles. This technique, along with dark-field images, revealed the uniform distribution of nanospheres in cells and could provide more accurate information on their intracellular microenvironment compared to the other particles. The region-dependent optical responses of nanoparticles in cells highlight the potential application of this technique for subcellular diagnosis when particles with proper size and morphology are chosen to reflect the microenvironment effects properly.
Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma
Authors: Gu Yanyan , Barwick Benjamin G. , Shanmugam Mala , Hofmeister Craig C. , Kaufman Jonathan , Nooka Ajay , Gupta Vikas , Dhodapkar Madhav , Boise Lawrence H. , Lonial Sagar 
Published: December 2020

AbstractProtein homeostasis is critical for maintaining eukaryotic cell function as well as responses to intrinsic and extrinsic stress. The proteasome is a major portion of the proteolytic machinery in mammalian cells and plays an important role in protein homeostasis. Multiple myeloma (MM) is a plasma cell malignancy with high production of immunoglobulins and is especially sensitive to treatments that impact protein catabolism. Therapeutic agents such as proteasome inhibitors have demonstrated significant benefit for myeloma patients in all treatment phases. Here, we demonstrate that the 11S proteasome activator PA28α is upregulated in MM cells and is key for myeloma cell growth and proliferation. PA28α also regulates MM cell sensitivity to proteasome inhibitors. Downregulation of PA28α inhibits both proteasomal load and activity, resulting in a change in protein homeostasis less dependent on the proteasome and leads to cell resistance to proteasome inhibitors. Thus, our findings suggest an important role of PA28α in MM biology, and also provides a new approach for targeting the ubiquitin-proteasome system and ultimately sensitivity to proteasome inhibitors.
Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells
Authors: Dos Santos Ancély F. , Inague Alex , Arini Gabriel S. , Terra Letícia F. , Wailemann Rosangela A. M. , Pimentel André C. , Yoshinaga Marcos Y. , Silva Ricardo R. , Severino Divinomar , de Almeida Daria Raquel Q. , Gomes Vinícius M. , Bruni-Cardoso Alexandre , Terra Walter R. , Miyamoto Sayuri , Baptista Maurício S. , Labriola Leticia 
Published: December 2020

AbstractLack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human breast cancer, marginally affecting healthy cells. In this study, we aimed to unveil the molecular mechanisms behind MB-PDT effectiveness and specificity towards tumor cells. Through lipidomics and biochemical approaches, we demonstrated that MB-PDT efficiency and specificity rely on polyunsaturated fatty acid-enriched membranes and on the better capacity to deal with photo-oxidative damage displayed by non-tumorigenic cells. We found out that, in tumorigenic cells, lysosome membrane permeabilization is accompanied by ferroptosis and/or necroptosis. Our results also pointed at a cross-talk between lysosome-dependent cell death (LDCD) and necroptosis induction after photo-oxidation, and contributed to broaden the understanding of MB-PDT-induced mechanisms and specificity in breast cancer cells. Therefore, we demonstrated that efficient approaches could be designed on the basis of lipid composition and metabolic features for hard-to-treat cancers. The results further reinforce MB-PDT as a therapeutic strategy for highly aggressive human breast cancer cells.
CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway
Authors: Huang Guanqun , Liang Min , Liu Haiyan , Huang Jianhong , Li Peiqing , Wang Chong , Zhang Yidan , Lin Ye , Jiang Xianhan 
Published: December 2020

AbstractCircular RNAs (circRNAs) have confirmed to participate in diverse biological functions in cancer. However, the expression patterns of circRNAs on hepatocellular carcinoma (HCC) remains unclear. In the present study, we clarified that hsa_circRNA_104348 was dramatically upregulated in HCC tissues and cells. Patients with HCC displaying high hsa_circRNA_104348 level possessed poor prognosis. Has_circ_104348 facilitated proliferation, migration, and invasion, meanwhile suppressed apoptosis of HCC cell. Furthermore, hsa_circRNA_104348 directly targeted miR-187–3p, could regulate miR-187-3p to affect proliferation, migration, invasion, and apoptosis of HCC cells, and may have effect on Wnt/β-catenin signaling pathway. Moreover, RTKN2 could be a direct target of miR-187-3p. In addition, knockdown of hsa_circRNA_104348 attenuated HCC tumorigenesis and lung metastasis in vivo. Taken together, these findings indicated that circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to promotes HCC progression by targeting miR-187–3p/RTKN2 axis and activating Wnt/β-catenin pathway.
Detection of eye contact with deep neural networks is as accurate as human experts
Authors: Chong Eunji , Clark-Whitney Elysha , Southerland Audrey , Stubbs Elizabeth , Miller Chanel , Ajodan Eliana L. , Silverman Melanie R. , Lord Catherine , Rozga Agata , Jones Rebecca M. , Rehg James M. 
Published: December 2020

AbstractEye contact is among the most primary means of social communication used by humans. Quantification of eye contact is valuable as a part of the analysis of social roles and communication skills, and for clinical screening. Estimating a subject’s looking direction is a challenging task, but eye contact can be effectively captured by a wearable point-of-view camera which provides a unique viewpoint. While moments of eye contact from this viewpoint can be hand-coded, such a process tends to be laborious and subjective. In this work, we develop a deep neural network model to automatically detect eye contact in egocentric video. It is the first to achieve accuracy equivalent to that of human experts. We train a deep convolutional network using a dataset of 4,339,879 annotated images, consisting of 103 subjects with diverse demographic backgrounds. 57 subjects have a diagnosis of Autism Spectrum Disorder. The network achieves overall precision of 0.936 and recall of 0.943 on 18 validation subjects, and its performance is on par with 10 trained human coders with a mean precision 0.918 and recall 0.946. Our method will be instrumental in gaze behavior analysis by serving as a scalable, objective, and accessible tool for clinicians and researchers.
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report
Authors: Buckland Matthew S. , Galloway James B. , Fhogartaigh Caoimhe Nic , Meredith Luke , Provine Nicholas M. , Bloor Stuart , Ogbe Ane , Zelek Wioleta M. , Smielewska Anna , Yakovleva Anna , Mann Tiffeney , Bergamaschi Laura , Turner Lorinda , Mescia Frederica , Toonen Erik J. M. , Hackstein Carl-Philipp , Akther Hossain Delowar , Vieira Vinicius Adriano , Ceron-Gutierrez Lourdes , Periselneris Jimstan , Kiani-Alikhan Sorena , Grigoriadou Sofia , Vaghela Devan , Lear Sara E. , Török M. Estée , Hamilton William L. , Stockton Joanne , Quick Josh , Nelson Peter , Hunter Michael , Coulter Tanya I. , Devlin Lisa ,   CITIID-NIHR COVID-19 BioResource Collaboration,   MRC-Toxicology Unit COVID-19 Consortium, Bradley John R. , Smith Kenneth G. C. , Ouwehand Willem H. , Estcourt Lise , Harvala Heli , Roberts David J. , Wilkinson Ian B. , Screaton Nick , Loman Nicholas , Doffinger Rainer , Lyons Paul A. , Morgan B. Paul , Goodfellow Ian G. , Klenerman Paul , Lehner Paul J. , Matheson Nicholas J. , Thaventhiran James E. D. 
Published: December 2020

AbstractThe response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral therapy. Here we report the use of remdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence of complement activation and a robust T cell response, the patient developed persistent SARS-CoV-2 pneumonitis, without progressing to multi-organ involvement. This unusual clinical course is consistent with a contribution of antibodies to both viral clearance and progression to severe disease. In the absence of these confounders, we take an experimental medicine approach to examine the in vivo utility of remdesivir. Over two independent courses of treatment, we observe a temporally correlated clinical and virological response, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance. We therefore provide evidence for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients.