bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons learned and real-world insights from implementing neutralizing monoclonal antibody programs for treatment of COVID-19
Authors: Ambrose Nalini , Amin Alpesh N. , Anderson Brian , Aten Adam , Canter Brian , Chow Daniel , D’Ambrosio Matthew , Danan Risa , Drews Ashley L. , Gaspar Fraser W. , Hendricks-Sturrup Rachele , O’Horo John , Razonable Raymund R. , Roberts Seth , Shepard Colin , Vahidy Farhaan , Webb Brandon , Yttri Jennifer 
Published: December 2024

Abstract
Coronavirus disease-2019 precipitated the rapid deployment of novel therapeutics, which led to operational and logistical challenges for healthcare organizations. Four health systems participated in a qualitative study to abstract lessons learned, challenges, and promising practices from implementing neutralizing monoclonal antibody (nMAb) treatment programs. Lessons are summarized under three themes that serve as critical building blocks for health systems to rapidly deploy novel therapeutics during a pandemic: (1) clinical workflows, (2) data infrastructure and platforms, and (3) governance and policy. Health systems must be sufficiently agile to quickly scale programs and resources in times of uncertainty. Real-time monitoring of programs, policies, and processes can help support better planning and improve program effectiveness. The lessons and promising practices shared in this study can be applied by health systems for distribution of novel therapeutics beyond nMAbs and toward future pandemics and public health emergencies.
The network ties behind commercial pension insurance purchase: empirical evidence from China
Authors: Huang Yao , Ma Yueru 
Published: December 2024

Abstract
China is entering a deeply aging society gradually, and individual pension allocation behavior has a profound impact on the practice and effect of national strategies to actively cope with population aging. This paper constructs a dyad model based on the influence path of social network ties in individual commercial pension insurance purchasing decisions, and then validates the path by building a generalized linear mixed model (GLMM) based on Bayesian approach with the national longitudinal sample data of China. The empirical results show that, firstly, strong ties social interaction (e.g., visiting friend's house) positively influences individuals' commercial pension insurance purchase behavior; secondly, the less the frequency of individual social interaction is, the less significant the positive influence of social interaction on individual commercial pension insurance product purchase is; finally, between 2013 and 2018, the intensity and frequency of social interactions among middle-aged and elderly people in China has been changed dramatically by the shock of the popularity and development of digital social tools. The influence of strong ties social interaction on insurance purchase behavior becomes weaker and weaker, while that of weak ties becomes stronger.
Cassirer v. Thyssen-Bornemisza Collection Foundation (9th Cir.)
Authors: Baylis Elena 
Published: December 2024

On January 9, 2024, the U.S. Ninth Circuit Court of Appeals issued a decision in Cassirer v. Thyssen-Bornemisza Collection Foundation. The case concerned ownership of a U.S. $30 million painting that had been stolen by the Nazis from its Jewish owner. More than six decades later, the pre-War owner's grandson discovered that the painting was on display in a Spanish museum and sought to reclaim it. The matter was in litigation in U.S. courts for almost twenty years. The outcome eventually turned on the issue of choice of law. The court's holding that Spanish law should apply resulted in a judgment that the defendant was the legal owner of the artwork. The court's decision is also notable for a concurring opinion asserting that the defendant should have voluntarily returned the painting to the plaintiffs in accordance with Spain's commitment to the Washington Conference Principles on Nazi-Confiscated Art (Washington Principles).
Mapping wild chervil (Anthriscus sylvestris) and anise (Myrrhis odorata) in urban green spaces: a subarctic case study
Authors: Luoma Mervi Orvokki , Tamayo Mariana , Sigurðsson Snorri 
Published: December 2024

Abstract
Urban areas are increasingly recognized as important centers of biodiversity. Nonetheless, invasive species can reduce this biodiversity, and cities can be hubs for alien plant invasions, highlighting the need to monitor urban biodiversity and problematic alien species. The goal of our study was to assess the distribution of wild chervil (Anthriscus sylvestris (L.) Hoffm.) and anise (Myrrhis odorata (L.) Scop.) in green spaces of Reykjavík, Iceland. This information is necessary to implement the city´s biodiversity strategy regarding invasive species. Both of these alien plants are spreading throughout Iceland, and Reykjavík´s high latitude (≥63° N) location and remoteness makes it an ideal case study to assess alien plant introductions and invasions in subarctic urban areas. We surveyed from May to October 2017 four green spaces (Laugarnes, Vatnsmýri, Elliðaárdalur, and Ægisiða), using AllTrailsPro and ArcGIS mobile applications. ANOVA and Bonferroni correction (post-hoc test) were used to compare the distribution and patch sizes of A. sylvestris and M. odorata among the study sites. We found that A. sylvestris covered at least 10% (15.5 ha) of the total area surveyed (158 ha), while M. odorata only covered ≤1 ha. Both plants were abundant near buildings, pathways, riversides, and streams, and they are expanding their distribution in Reykjavík´s green spaces. While A. sylvestris is clearly more established and widespread with larger patches (>100 m2), the distribution of M. odorata is more localized, occurring mainly in smaller patches (<100 m2). We recommend long-term monitoring to further assess M. odorata´s invasive potential, as well as testing and adopting integrated weed management strategies via adaptive management to control the distribution of A. sylvestris and that of other problematic alien plants. These actions, which are applicable to other subarctic cities, will help foster more proactive management encouraging urban biodiversity.
A simplified method to detect and monitor alien plant species with invasive potential through citizen science: an application from the European Union-funded LIFE medCLIFFS project volunteers data
Authors: Santana Carlos , Bosch-Guiu Arnau , Gómez-Bellver Carlos , López-Pujol Jordi , Nualart Neus 
Published: December 2024

Abstract
Citizen science is becoming very useful in surveying and monitoring biodiversity. Within the European Union LIFE medCLIFFS project, a network of volunteers has been established for the detection and long-term monitoring of invasive plant species that threaten the endemic flora of Mediterranean cliffs in north-eastern Spain. Through iNaturalist, volunteers record various data along a series of 1 km transects. Based on the ca. 700 observations collected by volunteers in 2023 (the first year of the project), a simple and visually-attractive methodology for assessing the recorded populations has been developed. This method classifies populations into one of three population dynamics categories: (1) propagative behavior (i.e., populations with seedlings or young plants but lacking senescent or dead individuals); (2) senescent behavior (i.e., showing senescent/dead plants but lacking seedlings/juveniles); and (3) a mixed behavior (i.e., containing both). This methodology, whose outputs are easily interpretable as heatmaps, allows the collection of large datasets on invasive plants by citizen scientists, with two main purposes: (1) knowing which species are most concerning based on simple, straightforward observations of their population dynamics; and (2) identifying which regions of the study area are more problematic and, thus, where management efforts should be directed.
Westerners underestimate global inequality
Authors: Ziano Ignazio , Onyeador Ivuoma Ngozi , Dhanda Nandita 
Published: December 2024

Abstract
Most global inequality is between countries, but inequality perceptions have mostly been investigated within the country. Six studies (total N = 2656, 5 preregistered, 1 incentivized for accuracy, 1 with a sample representative of the USA) show that Westerners (U.S. American, British, and French participants) believe that developing and middle-income countries’ GDP per capita is much closer to developed countries’ than it actually is, and that people in developing and middle-income countries have higher rates of car ownership, larger houses, and eat out more frequently than they actually do, meaning that Westerners underestimate global inequality. This misperception is underpinned by a convergence illusion: the belief that over time, poorer countries have closed the economic gap with richer countries to a larger extent than they have. Further, overestimating GDP per capita is negatively correlated with support for aid to the target country and positively correlated with a country’s perceived military threat. We discuss implications for inequality perceptions and for global economic justice.
The Overvaluation of the Portuguese Influence on the Formation of Brazilian Society in Raízes do Brasil
Authors: de Souza Maria Cristina 
Published: December 2024

Abstract
In this article, I argue that Sérgio Buarque de Holanda’s sociohistorical analyses of the formation of Brazilian society in Raízes do Brasil are based on a non-sociohistorical assumption. Holanda prioritizes the influence of the Portuguese colonizer on that formation based on a determinist-organicist standpoint. Although he also attributes deleterious traits to the Portuguese, he describes them as endowed with a consistent character able to adjust to adverse natural conditions and other ethnicities. As for African and Indigenous peoples, conversely, besides deprecating their temperament, Holanda reduces their influence to a peripheral and reinforcing function to the Portuguese temperament. Furthermore, he attributes the leading role in shaping Brazilian identity to the Portuguese. As I demonstrate, Holanda’s overvaluation of the Portuguese and his oversimplification of African and Indigenous peoples’ contribution to the sociohistorical development of Brazil reflect his view of peoples’ identities as naturally given, as organic-like features, and not as socially constructed.
The Birth and the Unanticipated Evolution of the Public History Movement
Authors: Karamanski Theodore J. 
Published: December 2024

Abstract
The public history movement in North America that was born amid the academic job crisis of the late 1970s aspired to a radical reformation of professional history’s audience from an inward focused conversation among professionals to one working with government and corporate institutions and in dialogue with the public. This essay focuses on the institutional evolution of the National Council on Public History (NCPH) to illustrate the unexpected, but not entirely unpropitious outcome that flowed from the failure of the organization’s original goals. How that movement failed and what it succeeded in creating may hold useful lessons for the contemporary public humanities campaign. In the late twentieth century, the public history movement failed to bring about a major reorientation of professional and academic history. In the attempt, however, it created an off shot of public history as one of a number of new but distinctly separate fields of academic historical practice. Unexpectedly, public history became a new academic specialty alongside other new fields from that era: native American history, environmental history, and gender history.
Children’s games and global politics: Masculinity, militarism, and the warrior hero
Authors: Jarvis Lee 
Published: December 2024

Abstract
Recent years have witnessed growing attention to popular culture’s role in the reproduction, negotiation, and contestation of global political life. This article extends this work by focusing on games targeted at young children as a neglected, yet rich site in which global politics is constituted. Drawing specifically on the Heroes of History card game in the Top Trumps franchise, I offer three original contributions. First, I demonstrate how children’s games contribute to the everyday (re)production of international relations through the contingent storying of global politics. Heroes of History’s narrative, visual organisation, and gameplay mechanics, I argue, construct world politics as an unchanging realm of conflict through their shared reproduction of a valorised, masculinised figure of the warrior hero. This construction, moreover, does important political work in insulating young players from the realities and generative structures of violence. Second, the polysemy of children’s games means they also provide opportunity for counter-hegemonic ‘readings’ of the world even in seemingly straightforward examples of the genre such as this. Third, engaging with such games as meaningful objects of analysis opens important new space for dialogue across International Relations literatures on children, popular culture, gender, the everyday, and heroism in world politics.
Present-biased heterogeneity, marginal propensity to consume, and wealth distribution
Authors: Li Yuan , Yang Jinqiang , Zhao Siqi 
Published: December 2024

Abstract
This paper studies the heterogeneity of households’ present bias in a heterogeneous-agent model. Our model jointly matches the average marginal propensities to consume and the wealth distribution in the USA, even when all wealth is liquid. A fiscal stimulus targeting households in the bottom half of the wealth distribution improves the consumption response. A financial literacy campaign removing present bias gets naive households out of the debt trap but harms sophisticated households’ wealth accumulation due to a lower equilibrium interest rate. Finally, we show that a borrowing cost penalty and illiquidity both discipline excessive borrowing and are therefore potential remedies for present bias and naivete.
Mitigation of AI adoption bias through an improved autonomous AI system for diabetic retinal disease
Authors: Abràmoff Michael D. , Lavin Philip T. , Jakubowski Julie R. , Blodi Barbara A. , Keeys Mia , Joyce Cara , Folk James C. 
Published: December 2024

AbstractWhere adopted, Autonomous artificial Intelligence (AI) for Diabetic Retinal Disease (DRD) resolves longstanding racial, ethnic, and socioeconomic disparities, but AI adoption bias persists. This preregistered trial determined sensitivity and specificity of a previously FDA authorized AI, improved to compensate for lower contrast and smaller imaged area of a widely adopted, lower cost, handheld fundus camera (RetinaVue700, Baxter Healthcare, Deerfield, IL) to identify DRD in participants with diabetes without known DRD, in primary care. In 626 participants (1252 eyes) 50.8% male, 45.7% Hispanic, 17.3% Black, DRD prevalence was 29.0%, all prespecified non-inferiority endpoints were met and no racial, ethnic or sex bias was identified, against a Wisconsin Reading Center level I prognostic standard using widefield stereoscopic photography and macular Optical Coherence Tomography. Results suggest this improved autonomous AI system can mitigate AI adoption bias, while preserving safety and efficacy, potentially contributing to rapid scaling of health access equity. ClinicalTrials.gov NCT05808699 (3/29/2023).
Distinguishing Daratumumab from Endogenous Monoclonal Proteins in Serum from Multiple Myeloma Patients Using an Automated Mass Spectrometry System
Authors: Barnidge David , Sakrikar Dhananjay , Kubicki Tadeusz , Derman Benjamin A , Jakubowiak Andrzej J , Lakos Gabriella 
Published: December 2024

Abstract

Background
Therapeutic monoclonal antibodies (t-mAbs) may interfere with electrophoresis-based methods used to monitor multiple myeloma (MM), which can create inaccurate results. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is an alternative to gels distinguishing between endogenous M-proteins and t-mAbs based on molecular mass.

Methods
Serum samples (n = 109) from 34 MM patients receiving Dara-KRd were collected 14 or 28 days postdaratumumab administration. Samples were analyzed using the EXENT® Analyzer that combines automated immunopurification and MALDI-TOF MS for the isotyping and quantification of monoclonal immunoglobulins.

Results
Daratumumab was identified in 103 out of 109 samples (94.5%). In all IgGλ (n = 8), IgAκ (n = 8), and IgAλ (n = 2) patients, the M-protein and daratumumab were detected. Of the IgGκ patients (n = 18), 5 patients had a total of 6 samples where the M-protein was detected but daratumumab was not. There was no difference in the detection rate of daratumumab between samples taken 14 and 28 days postadministration with the median daratumumab concentration being 0.95 and 0.54 g/L, respectively. A precision study was also performed on 25 replicates containing 1 g/L daratumumab in serum where a coefficient of variation of 4.2% was observed as determined by the EXENT Analyzer.

Conclusions
The Immunoglobulin Isotypes (GAM: IgG, IgA, and IgM) for the EXENT Analyzer detected and distinguished a daratumumab kappa light chain peak from an M-protein light chain peak in MM patient serum when resolved by the mass spectrometer.
Small bowel obstruction caused by transmesenteric hernia in a patient with complex medical history: a case report
Authors: Ahmad Y Karim , Alexia Herber , Sivarama Kotikalapudi 
Published: December 2024

Abstract
This case report presents a rare instance of small bowel obstruction due to a transmesenteric hernia in a 47-year-old male with a complex medical history. The patient presented with acute abdominal pain, constipation, and urinary retention. Diagnostic laparoscopy revealed bowel ischemia, and open laparotomy confirmed a transmesenteric hernia with necrotic small bowel requiring resection. Postoperative recovery was uneventful, and the patient was discharged with follow-up plans. This case underscores the importance of considering internal abdominal hernias in the differential diagnosis of acute abdominal pain.
Patient-reported quality of life in Asian patients with ER+/HER2− advanced breast cancer treated with palbociclib plus letrozole in the PALOMA-4 trial
Authors: Xu Binghe , Hu Xichun , Li Wei , Sun Tao , Shen Kunwei , Huang ChiunSheng , Sriuranpong Virote , Ngan Roger KC , Chia Yee H. , Reisman Arlene , Zhao Huadong , Shen Jiayun , Broughton Edward 
Published: December 2024

Abstract

Background:
Palbociclib plus an aromatase inhibitor is approved for treatment of patients with ER+/HER2− advanced breast cancer (ABC). In the PALOMA-4 trial, adding palbociclib to letrozole prolonged median progression-free survival in Asian women with ER+/HER2− ABC. Here, we report patient-reported outcomes (PROs) from PALOMA-4.

Methods:
PALOMA-4 was a randomized, double-blind, phase 3 trial of palbociclib plus letrozole vs. placebo plus letrozole treatment in postmenopausal Asian women with ER+/HER2− ABC. PROs were longitudinally assessed using the Functional Assessment of Cancer Therapy–Breast (FACT-B) and EuroQoL 5D three level (EQ-5D-3L) questionnaires. Group comparisons were analyzed using longitudinal, mixed-effects models.

Results:
Patients were randomly assigned to palbociclib plus letrozole (n = 169) or placebo plus letrozole (n = 171) treated groups. No significant between-arm differences in change from baseline were observed in FACT-B and its subscales, or the EQ-5D-3L index. A significant, but not clinically meaningful difference was observed in change from baseline in mean EQ-VAS score favoring palbociclib plus letrozole (3.36; 95% confidence interval [CI], 0.88–5.83; P = 0.008). When patients from both arms were combined, significant differences in the mean change from baseline for FACT-B total were observed favoring treatment responders vs. non-responders (3.84; 95% CI, 0.33–7.36; P = 0.032) and for the Breast Cancer Subscale favoring patients without disease progression vs. those with progression (0.97; 95% CI, 0.05–1.89; P = 0.038).

Conclusions:
Quality of life was maintained when palbociclib was added to letrozole in Asian women with ABC. These findings are consistent with PALOMA-2 results and support the use of palbociclib as first-line treatment in postmenopausal Asian patients with ER+/HER2− ABC.

Registration:

clinicaltrials.gov, NCT02297438
First comparison between artificial intelligence-guided coronary computed tomography angiography versus single-photon emission computed tomography testing for ischemia in clinical practice
Authors: Cho Geoffrey W. , Sayed Sammy , D’Costa Zoee , Karlsberg Daniel W. , Karlsberg Ronald P. 
Published: December 2024

Background
Noninvasive cardiac testing with coronary computed tomography angiography (CCTA) and single-photon emission computed tomography (SPECT) are becoming alternatives to invasive angiography for the evaluation of obstructive coronary artery disease. We aimed to evaluate whether a novel artificial intelligence (AI)-assisted CCTA program is comparable to SPECT imaging for ischemic testing.

Methods
CCTA images were analyzed using an artificial intelligence convolutional neural network machine-learning-based model, atherosclerosis imaging-quantitative computed tomography (AI-QCT)ISCHEMIA. A total of 183 patients (75 females and 108 males, with an average age of 60.8 years ± 12.3 years) were selected. All patients underwent AI-QCTISCHEMIA-augmented CCTA, with 60 undergoing concurrent SPECT and 16 having invasive coronary angiograms. Eight studies were excluded from analysis due to incomplete data or coronary anomalies.

Results
A total of 175 patients (95%) had CCTA performed, deemed acceptable for AI-QCTISCHEMIA interpretation. Compared to invasive angiography, AI-QCTISCHEMIA-driven CCTA showed a sensitivity of 75% and specificity of 70% for predicting coronary ischemia, versus 70% and 53%, respectively for SPECT. The negative predictive value was high for female patients when using AI-QCTISCHEMIA compared to SPECT (91% vs. 68%, P = 0.042). Area under the receiver operating characteristic curves were similar between both modalities (0.81 for AI-CCTA, 0.75 for SPECT, P = 0.526). When comparing both modalities, the correlation coefficient was r = 0.71 (P < 0.04).

Conclusion
AI-powered CCTA is a viable alternative to SPECT for detecting myocardial ischemia in patients with low- to intermediate-risk coronary artery disease, with significant positive and negative correlation in results. For patients who underwent confirmatory invasive angiography, the results of AI-CCTA and SPECT imaging were comparable. Future research focusing on prospective studies involving larger and more diverse patient populations is warranted to further investigate the benefits offered by AI-driven CCTA.