bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten-year adherence to continuous positive airway pressure treatment in patients with moderate-to-severe obstructive sleep apnea
Authors: Tsuyumu Matsusato , Tsurumoto Tadao , Iimura Jiro , Nakajima Tsuneya , Kojima Hiromi 
Published: February 2020

AbstractPurposeThis study aimed to evaluate the 10-year adherence to and identify the predictors of dropout from continuous positive airway pressure (CPAP) treatment for patients with moderate-to-severe obstructive sleep apnea (OSA).MethodsWe retrospectively analyzed the continuity, dropout, or other behaviors of 181 patients who initiated CPAP treatment at the Tokyo Dental College Ichikawa General Hospital from January 2003 to June 2005.ResultsAmong a total of 181 patients, 56 (30.9%) dropped out of the treatment. Among the 125 patients who did not dropout, 54 continued CPAP treatment for > 10 years, 16 completed the treatment with OSA improvement, and 7 could not complete the treatment owing to unavoidable reasons such as death, dementia, hospitalization for serious illness, or migration to other countries. Further, 47 patients moved to another facility, whereas 1 patient purchased a CPAP device and stopped visiting our facility. Among the 56 patients who dropped out, approximately 50% of the patients dropped out within a year, and all dropped out within 76 months. Comparing demographics, OSA parameters, and CPAP parameters between the patients who did and did not drop out of the treatment, Cox regression analysis indicated that body mass index (BMI) and the first-month utilization rate were clinical variables that were independently associated with discontinuation of CPAP treatment.ConclusionThe results of this study show that BMI and the first-month utilization rate of CPAP treatment are the predictors of the long-term adherence to this treatment.
Microplastics in freshwater fish from Central European lowland river (Widawa R., SW Poland)
Authors: Kuśmierek Natalia , Popiołek Marcin 
Published: February 2020

AbstractIn contrast to marine organisms, the presence of microplastics (MPs) in freshwater animals remains insufficiently studied. The aim of this study was to identify the occurrence of MPs in the digestive tracts of two fish species from a small lowland river (Widawa R., SW Poland). In total, 202 gudgeons and 187 roaches were collected, of which 54.5% and 53.9% had ingested MP-like particles, respectively. Feeding type and behaviour, sex and capture site (above or below the dam reservoir) did not affect the number of fish with MP-like particles.
Enhancing the Stability of Passive Film on 304 SS by Chemical Modification in Alkaline Phosphate–Molybdate Solutions
Authors: Pan Chengcheng , Song Yang , Jin Weixian , Qin Zhenbo , Song Shizhe , Hu Wenbin , Xia Da-Hai 
Published: February 2020

AbstractThe purpose of this work was to enhance the corrosion resistance of the passive film on 304 stainless steel (SS) by chemical modification in alkaline phosphate–molybdate solutions. The 304 SS was passivated in both phosphate and phosphate–molybdate mixed solutions to investigate the effect of molybdate on its corrosion resistance. The experimental results indicated that the passive film showed better corrosion resistance in Cl−-containing solutions after modification in phosphate–molybdate solutions than in phosphate-only solutions. Energy-dispersive spectroscopy analyses revealed that the passive film formed in phosphate–molybdate solutions contained Mo and P after modification, which is the reason for the enhanced corrosion resistance.
Intergenerational transmission of socio‐economic status: The role of neighborhood effects
Authors: Ryabov Igor 
Published: February 2020

ABSTRACTIntroductionLittle attention has been paid to the role of neighborhoods as a predictor of intergenerational transmission of socio‐economic status. This study uses a nationally representative, longitudinal sample from the United States to examine how neighborhoods impact racial/ethnic disparities in the intergenerational transmission of socio‐economic status.MethodsThe study sample is derived from Waves 1 and 4 of the National Longitudinal Study of Adolescent to Adult Health. The sample size comprises 13,738 participants (aged 15 at Wave 1; 51% female). Multilevel regression is used to predict racial/ethnic disparities in intergenerational transmission of socio‐economic status. Six neighborhood‐level indicators are regressed on the indicators of intergenerational transmission of education, income and occupational prestige, while controlling for a range of individual socio‐demographic variables.ResultsResults reveal that: (1) African‐American and Hispanic children are less likely to surpass their parents’ levels of education, income and occupational prestige than Asian‐Pacific Islander and non‐Hispanic white children; (2) these racial/ethnic differences in intergenerational transmission of socio‐economic status are attenuated but not fully explained by neighborhood‐level indicators; (3) all but one of the neighborhood‐level factors examined were significant in predicting the pace of intergenerational transmission of socio‐economic status.ConclusionsThe implication of these results is that policies aimed at reducing inequalities between residential neighborhoods are likely to beneficially affect all racial/ethnic groups but are not sufficient in reducing racial/ethnic disparities in intergenerational transmission of socio‐economic status.
Population structure and genetic diversity ofMagnolia cubensissubsp.acunae(Magnoliaceae): effects of habitat fragmentation and implications for conservation
Authors: Hernández Majela , Palmarola Alejandro , Veltjen Emily , Asselman Pieter , Testé Ernesto , Larridon Isabel , Samain Marie-Stéphanie , González-Torres Luis R. 
Published: February 2020

AbstractGenetic data on threatened plant populations can facilitate the development of adequate conservation strategies to reduce extinction risk. Such data are particularly important for species affected by habitat fragmentation such asMagnolia cubensissubsp.acunae, a Critically Endangered magnolia subspecies endemic to Cuba. Using genetic data from 67 individuals, we aimed to evaluate the effect of habitat fragmentation on two subpopulations in the Guamuhaya mountain range, in Topes de Collantes Protected Natural Landscape and Lomas de Banao Ecological Reserve. We characterize the structure and genetic diversity of these subpopulations, with the objective of managing their conservation more effectively. We used Landsat satellite images to determine land-cover types at the two locations and calculated indices of habitat fragmentation. For genetic analyses, we extracted DNA from the leaf tissue of individuals from the two subpopulations and used 11 microsatellite markers to genotype them. We calculated heterozygosity, allelic richness and theF-statistics, to evaluate genetic variability. The montane rainforest in Topes de Collantes was most affected by habitat fragmentation, with smaller patches of more irregular shapes, compared to submontane forest at this location and both montane and submontane forests in Lomas de Banao. Genetic diversity was higher in Topes de Collantes, but we found no genetic differentiation between subpopulations. Our findings suggest the two subpopulations can be considered a single evolutionary unit and conservation entity. We propose to use individuals from both subpopulations for reinforcement to increase the overall genetic diversity of the subspecies.
An outbreak of campylobacteriosis at a hotel in England: the ongoing risk due to consumption of chicken liver dishes
Authors: Wensley A. , Padfield S. , Hughes G. J. 
Published: February 2020

Abstract
Despite a sizeable evidence base for the risk of campylobacteriosis associated with eating chicken liver pâté, associated outbreaks continue to occur. In January 2017, six cases of campylobacteriosis reported having eaten a Christmas set-menu meal at the same hotel in North Yorkshire, England on the same day. A retrospective cohort study was undertaken to test the null hypothesis that consumption of individual food items was not associated with an increased risk of illness. There were 19 cases of campylobacteriosis linked to the outbreak; seven confirmed and 12 probable cases. Chicken liver pâté was the food item most strongly associated with illness (P < 0.001) with a corresponding high crude relative risk (12.95). This relationship was supported by multivariable analysis, sensitivity analyses and a clear dose–response relationship. Three cases reported an incubation period of <24 h, consistent with other outbreaks of campylobacteriosis associated with consumption of poultry liver. The findings were suggestive of a single point source exposure with a strong association between the consumption of chicken liver pâté and campylobacteriosis. This outbreak highlights that despite evidence that simple cooking techniques can ensure that all campylobacter are killed during cooking, outbreaks continue to occur. Public and professional awareness needs to be raised through a strategic communication plan to reduce the risk of further outbreaks of campylobacteriosis linked to incorrectly cooked chicken liver dishes.
Calling the cavalry: firm-level investment in the face of decentralized expropriation
Authors: Marques Israel , Levina Irina , Kazun Anton , Yakovlev Andrei 
Published: February 2020

AbstractWhat characteristics of firms give them the confidence to invest in settings rife with expropriation by local officials? Empirically, firms in the developing world often face the threat of expropriation from local agents of the state rather than a centralized autocrat. Because policing local officials is costly, the state cannot easily credibly commit to doing so. This has negative consequences for investment. We argue that one solution is to allow firms to approach the state directly to ask for intervention. Not all firms are equally able to successfully get the attention of the state, however, so this mechanism only works for some. We develop an argument about the firm-level characteristics – large-scale employment, political connections, foreign ownership, and business association membership – that should make the central state more attentive to calls for help. Because firm with these characteristics are more likely to secure intervention against predatory bureaucrats, the latter are less likely to try to expropriate them. These firms' investment decisions should be less sensitive to local expropriation than other firms. We test this argument using data on cases of decentralized expropriation across Russia's regions and firm-level data from a cross-regional, large scale survey of Russian firms.
Composition of Magma and Characteristics of the Hydrothermal System of Newberry Volcano, Oregon, From Magnetotellurics
Authors: Bowles‐Martinez E. , Schultz A. 
Published: February 2020

AbstractWe use 3‐D magnetotellurics to improve our understanding of the structure and magma composition of Newberry Volcano in Oregon, USA. Newberry is a broad shield volcano with a summit caldera and strongly bimodal magmatism. Newberry has long been the subject of geothermal exploration research, but that work has focused on the volcano's west flank, leaving the caldera largely unstudied with geophysical methods until recently. Our modeling shows a relatively resistive magma reservoir of approximately 50 Ωm. Our work builds upon recent seismic models and petrological analysis to interpret Newberry's magma reservoir as a dry rhyolite with 8–11% partial melt, which matches the seismically determined melt fraction. Finding the conditions within the magma reservoir that allow the resistivity and seismic analysis to come to the same melt fraction helps us narrow down the magma temperature and composition. From this we infer a dry rhyolitic magma at 850 °C. We also image a prominent vertical conductive anomaly along the south rim below the vent that produced the most recent eruption. The anomaly extends from magma reservoir depths of 3 km to 1 km below the surface where it disperses into the caldera fill. We interpret this as the main conduit for magmatic fluids to reach Newberry's hydrothermal system. Other features that our model shows include higher conductivity along the caldera rim and a resistive older pluton on the west flank.
QBO Changes in CMIP6 Climate Projections
Authors: Butchart Neal , Anstey James A. , Kawatani Yoshio , Osprey Scott M. , Richter Jadwiga H. , Wu Tongwen 
Published: February 2020

AbstractPhase 6 of the Coupled‐Model Intercomparison Project (CMIP6) is the first in which a significant number of models include a well‐resolved stratosphere. Changes in equatorial stratospheric variability in historical and Shared Socioeconomic Pathways (SSPs) scenario simulations are investigated in 10 models with realistic quasi‐biennial oscillations (QBO). All project a weakening of the QBO throughout the stratosphere for SSP370 and SSP585 scenarios and for 1960 to 2010. The weakening is strongest in the lower stratosphere, ranging from
% to
% to
% per decade at 50 hPa for SSP585, SSP370, and historical simulations, respectively. At 20 hPa a weakening of both westward and eastward phases contributes though the weakening eastward phase is only seen in 7 of the 10 models. Similar robust weakening occurs for the temperature QBO, but only from 30 hPa upward. In both scenarios the QBO period decreases in 7 of the 10 models.
Long‐term Impacts of Permafrost Thaw on Carbon Storage in Peatlands: Deep Losses Offset by Surficial Accumulation
Authors: Heffernan Liam , Estop‐Aragonés Cristian , Knorr Klaus‐Holger , Talbot Julie , Olefeldt David 
Published: February 2020

AbstractPeatlands in northern permafrost regions store a significant proportion of global soil carbon. Recent warming is accelerating peatland permafrost thaw and thermokarst collapse, exposing previously frozen peat to microbial decomposition and potential mineralization into greenhouse gases. Here, we show from a site in the sporadic‐discontinuous permafrost zone of western Canada that thermokarst collapse leads to neither large losses nor gains following thaw, as deep carbon losses are offset by surficial accumulation. We collected peat cores along two thaw chronosequences, from peat plateau, through young (~30 years since thaw), intermediate (~70 years), and mature (~200 years) thermokarst bog locations. Macrofossil and 14C analysis showed synchronicity of peatland development until recent thaw, with wetland initiation ~8,500 cal yr BP followed by succession through peatland stages prior to permafrost aggradation ~1,800 cal yr BP. Analysis and modeling of soil carbon stocks indicated 8.7 ± 12.4 kg C m−2 of carbon accumulated prior to thaw was lost in ~200 years post‐thaw. Despite these losses, there was no observed increase in peat humification as assessed by Fourier transform infrared and C:N ratios. Rapid peat accumulation post‐thaw (9.8 ± 1.6 kg C m−2 over 200 years) offset deeper losses. Our approach constrains the net carbon balance to be between uptake of 27.3 g C m−2 yr−1 and loss of 106.6 g C m−2 yr−1 over 200 years post‐thaw. While our approach cannot determine whether thermokarst bogs in the sporadic‐discontinuous permafrost zone act as long‐term carbon sinks or sources post‐thaw, our study better constrains post‐thaw C losses and gains.
Changes in Antecedent Soil Moisture Modulate Flood Seasonality in a Changing Climate
Authors: Wasko Conrad , Nathan Rory , Peel Murray C. 
Published: February 2020

AbstractDue to difficulties in identifying a climate change signal in flood magnitude, it has been suggested that shifts in flood timing, that is, the day of annual streamflow maxima, may be detectable. Here, we use high‐quality streamflow, largely free of snowmelt, from 221 catchments across Australia to investigate the influence of shifts in soil moisture and rainfall timing on annual streamflow maxima timing. In tropical areas we find that flood timing is strongly linked to the timing of both rainfall and soil moisture annual maxima. However, in southern Australia flood timing is more correlated with soil moisture maxima than rainfall maxima. The link between flood, soil moisture, and rainfall timing is confounded by event severity: For less extreme events flood timing is more likely to correspond to soil moisture timing, whereas rainfall timing becomes increasingly important as flood severity increases. Using circular regression to investigate nonstationarity, we find that flood timing is shifting to earlier in the year in the tropics and later in the year in the southwest of the continent, consistent with changes in mean and extreme rainfall and shifts in soil moisture timing due to tropical expansion. In southeast Australia, there is evidence that the mechanisms controlling flood seasonality are changing with a reversal of trends post Millennium Drought. Overall, changes in soil moisture timing, compared to changes in rainfall timing, are found to have a greater influence on changes in annual maxima streamflow flood timing.
Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
Authors: Popovici Jean , Roesch Camille , Carias Lenore L. , Khim Nimol , Kim Saorin , Vantaux Amelie , Mueller Ivo , Chitnis Chetan E. , King Christopher L. , Witkowski Benoit 
Published: February 2020

AbstractAntigenic variation, the capacity to produce a range of variable antigens, is a well-described strategy of Plasmodium and other parasites to evade host immunity. Here, we show that gene amplification is an additional evasion mechanism used by Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand involved in reticulocyte invasion. PvDBP gene amplification leads to increased mRNA levels and protects P. vivax in vitro against invasion inhibitory human monoclonal antibodies targeting a conserved binding domain of DBP. Patient samples suggest that parasites with increased pvdbp copy number are able to infect individuals with naturally acquired antibodies highly blocking the binding of PvDBP to the Duffy receptor. These results show that gene copy number variation affect the parasite’s ability to evade anti-PvDBP humoral immunity.
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Authors: Zhao Bo , Liu Pingyu , Fukumoto Takeshi , Nacarelli Timothy , Fatkhutdinov Nail , Wu Shuai , Lin Jianhuang , Aird Katherine M. , Tang Hsin-Yao , Liu Qin , Speicher David W. , Zhang Rugang 
Published: February 2020

AbstractCyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during senescence. cGAS-mediated inflammation is essential for the antitumor effects of immune checkpoint blockade. However, the mechanism by which cGAS recognizes cytoplasmic chromatin is unknown. Here we show that topoisomerase 1-DNA covalent cleavage complex (TOP1cc) is both necessary and sufficient for cGAS-mediated cytoplasmic chromatin recognition and SASP during senescence. TOP1cc localizes to cytoplasmic chromatin and TOP1 interacts with cGAS to enhance the binding of cGAS to DNA. Retention of TOP1cc to cytoplasmic chromatin depends on its stabilization by the chromatin architecture protein HMGB2. Functionally, the HMGB2-TOP1cc-cGAS axis determines the response of orthotopically transplanted ex vivo therapy-induced senescent cells to immune checkpoint blockade in vivo. Together, these findings establish a HMGB2-TOP1cc-cGAS axis that enables cytoplasmic chromatin recognition and response to immune checkpoint blockade.
Primary cell wall inspired micro containers as a step towards a synthetic plant cell
Authors: Paulraj T. , Wennmalm S. , Wieland D.C.F. , Riazanova A. V. , Dėdinaitė A. , Günther Pomorski T. , Cárdenas M. , Svagan A. J. 
Published: February 2020

AbstractThe structural integrity of living plant cells heavily relies on the plant cell wall containing a nanofibrous cellulose skeleton. Hence, if synthetic plant cells consist of such a cell wall, they would allow for manipulation into more complex synthetic plant structures. Herein, we have overcome the fundamental difficulties associated with assembling lipid vesicles with cellulosic nanofibers (CNFs). We prepare plantosomes with an outer shell of CNF and pectin, and beneath this, a thin layer of lipids (oleic acid and phospholipids) that surrounds a water core. By exploiting the phase behavior of the lipids, regulated by pH and Mg2+ ions, we form vesicle-crowded interiors that change the outer dimension of the plantosomes, mimicking the expansion in real plant cells during, e.g., growth. The internal pressure enables growth of lipid tubules through the plantosome cell wall, which paves the way to the development of hierarchical plant structures and advanced synthetic plant cell mimics.
An organic/inorganic electrode-based hydronium-ion battery
Authors: Guo Zhaowei , Huang Jianhang , Dong Xiaoli , Xia Yongyao , Yan Lei , Wang Zhuo , Wang Yonggang 
Published: February 2020

AbstractHydronium-ion batteries are regarded as one of the most promising energy technologies as next-generation power sources, benefiting from their cost effectivity and sustainability merits. Herein, we propose a hydronium-ion battery which is based on an organic pyrene-4,5,9,10-tetraone anode and an inorganic MnO2@graphite felt cathode in an acid electrolyte. Its operation involves a quinone/hydroquinone redox reaction on anode and a MnO2/Mn2+ conversion reaction on cathode, in parallel with the transfer of H3O+ between two electrodes. The distinct operation mechanism affords this hydronium-ion battery an energy density up to 132.6 Wh kg−1 and a supercapacitor-comparable power density of 30.8 kW kg−1, along with a long-term cycling life over 5000 cycles. Furthermore, surprisingly, this hydronium-ion battery works well even with a frozen electrolyte under −40 °C, and superior rate performance and cycle stability remain at −70 °C.
A molecular switch regulating transcriptional repression and activation of PPARγ
Authors: Shang Jinsai , Mosure Sarah A. , Zheng Jie , Brust Richard , Bass Jared , Nichols Ashley , Solt Laura A. , Griffin Patrick R. , Kojetin Douglas J. 
Published: February 2020

AbstractNuclear receptor (NR) transcription factors use a conserved activation function-2 (AF-2) helix 12 mechanism for agonist-induced coactivator interaction and NR transcriptional activation. In contrast, ligand-induced corepressor-dependent NR repression appears to occur through structurally diverse mechanisms. We report two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation. Helix 12 is displaced from the solvent-exposed active conformation and occupies the orthosteric ligand-binding pocket enabled by a conformational change that doubles the pocket volume. Paramagnetic relaxation enhancement (PRE) NMR and chemical crosslinking mass spectrometry confirm the repressive helix 12 conformation. PRE NMR also defines the mechanism of action of the corepressor-selective inverse agonist T0070907, and reveals that apo-helix 12 exchanges between transcriptionally active and repressive conformations—supporting a fundamental hypothesis in the NR field that helix 12 exchanges between transcriptionally active and repressive conformations.