bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulations and observational tests of primordial magnetic fields from Cosmic Microwave Background constraints
Authors: Vazza F , Paoletti D , Banfi S , Finelli F , Gheller C , O’Sullivan S P , Brüggen M 
Published: November 2020

ABSTRACT
We present the first cosmological simulations of primordial magnetic fields derived from the constraints by the Cosmic Microwave Background observations, based on the fields’ gravitational effect on cosmological perturbations. We evolved different primordial magnetic field models with the enzo code and compared their observable signatures (and relative differences) in galaxy clusters, filaments, and voids. The differences in synchrotron radio powers and Faraday rotation measure from galaxy clusters are generally too small to be detected, whereas differences present in filaments will be testable with the higher sensitivity of the Square Kilometre Array. However, several statistical full-sky analyses, such as the cross-correlation between galaxies and diffuse synchrotron power, the Faraday rotation structure functions from background radio galaxies, or the analysis of arrival direction of ultra-high-energy cosmic rays, can already be used to constrain these primordial field models.
On the energy and redshift distributions of fast radio bursts
Authors: Zhang Rachel C , Zhang Bing , Li Ye , Lorimer Duncan R 
Published: November 2020

ABSTRACT
Fast radio bursts (FRBs) are millisecond-duration radio transients from cosmological distances. Their isotropic energies follow a power-law distribution with a possible exponential cut-off, but their intrinsic redshift distribution, which contains information about the FRB sources, is not well understood. We attempt to constrain both distributions by means of Monte Carlo simulations and comparing the simulations results with the available FRB specific fluence distribution, dispersion measure (DM) distribution, and the estimated energy distribution data. Two redshift distribution models, one tracking the star formation history of the Universe and another tracking compact binary mergers, are tested. For the latter model, we consider three merger delay time-scale distribution (Gaussian, lognormal, and power-law) models. Two FRB samples detected by Parkes and the Australian Square Kilometre Array Pathfinder, respectively, are used to confront the simulation results. We confirm the ∼−1.8 power-law index for the energy distribution but the exponential cut-off energy of the distribution, if any, is unconstrained. For the best energy distribution model, none of the redshift distributions we considered are rejected by the data. A future, larger, uniform FRB sample (such as the one collected by the Canadian Hydrogen Intensity Mapping Experiment) can provide better constraints on the intrinsic FRB redshift distribution using the methodology presented in this paper.
Quality of patient-reported outcome reporting according to the CONSORT statement in randomized controlled trials with glioblastoma patients
Authors: Garnier Louis , Charton Emilie , Falcoz Antoine , Paget-Bailly Sophie , Vernerey Dewi , Jary Marine , Ducray François , Curtit Elsa 
Published: November 2020

Abstract

Background
Randomized controlled trials (RCTs) represent the best evidence in oncology research. Glioblastoma is the most frequent and deadly primary brain tumor, affecting health-related quality of life. An important end point is patient-reported outcomes (PROs). There are no data regarding how well publications of glioblastoma RCTs report PROs. A specific PRO extension of the Consolidated Standards of Reporting Trials (CONSORT) statement was created to improve the quality of reporting. The aim of this study was to evaluate adherence to the CONSORT-PRO statement in reporting RCTs addressing the treatment of patients with glioblastoma. PRO analysis methodology was explored and criteria associated with higher quality of reporting were investigated.

Methods
From PubMed/MEDLINE and the Cochrane Library databases, all phase 2 and 3 RCTs related to glioblastoma published between 1995 and 2018 were reviewed according to the CONSORT-PRO statements. An overall quality score on a 0 to 100 scale was defined based on these criteria and factors associated with this score were identified.

Results
Forty-four RCTs were identified as relevant according to predefined criteria. The median overall quality score was 26. No difference was observed regarding reporting quality over the years. CONSORT-PRO items concerning data collection and analysis were poorly reported. Thirty-four trials (77%) used longitudinal data. The most frequent statistical method for PROs analysis was the mean change from baseline (63%). Factors associated with improved overall quality score were the presence of a secondary publication dedicated to PROs results, the statement of any targeted dimensions, and when trials reported results using multiple methods.

Conclusion
Despite the importance of measuring PROs in patients with glioblastoma, employment of the CONSORT-PRO statement is poor in RCTs.
Prevalence of Young Adult Vaping, Substance Vaped, and Purchase Location Across Five Categories of Vaping Devices
Authors: Cwalina Sam N , Braymiller Jessica L , Leventhal Adam M , Unger Jennifer B , McConnell Rob , Barrington-Trimis Jessica L 
Published: November 2020

Abstract

Introduction
The rapidly evolving landscape of vaping devices has complicated analyses of use patterns among youth and young adults. The current study describes the prevalence of use, substances vaped, and purchasing behaviors across five different vaping device categories.

Aims and Methods
Participants (n = 2505; mean age = 19.2, SD = 0.46) from a cohort in the Los Angeles area completed web-based surveys from June 2018 to October 2019. For each of four device type categories depicted via digital images (any pod-style vape, cigalike, box-mod, vape pen) and for JUUL specifically, participants reported ever and past 30-day use, substance vaped (mostly nicotine, nicotine and tetrahydrocannabinol [THC], mostly THC, neither), ownership of device (yes/no), where they obtained that device (eg, purchased themselves, from a friend), and if purchased, purchase location (eg, vape shop, online).

Results
Overall, 44.9% reported ever use, and 26.2% reported past 30-day use of at least one of the devices. The prevalence of past 30-day use was highest for pod-style vapes (any pod = 17.0%; JUUL = 15.1%). Among respondents who reported ever owning any device (n = 643 [25.7%]), 59.9% reported purchasing the device themselves, despite not being of legal purchasing age (15.4% of total sample); across all device types, products were most often purchased in vape shops or online.

Conclusions
Across all devices, the prevalence of self-purchase of vaping devices among underage young adults in the Los Angeles area was high, and most were purchased from a vape shop or online. Tobacco control policies to prevent underage purchase of tobacco products—particularly among never smokers—are needed.

Implications
A high proportion of underage young adults reported owning their own vaping device and having purchased it themselves from a vape shop or online. Stronger tobacco control policies and better enforcement efforts are needed to successfully prevent underage purchase of tobacco products.
Our Love Affair with Drugs
Authors: Winter Jerrold 
Published: November 2020

Abstract
Prescription, illicit, and recreational drugs touch all of our lives yet a basic understanding of these chemicals is largely absent among Americans. Jerrold Winter offers a comprehensive account of psychoactive drugs, chemicals which influence our brains in myriad ways. Manifestations of their influence on the brain are quite varied. There may be the comfort provided by opioids to those who are dying or in pain or, in everyday life, the surge of contentment for the users of caffeine, nicotine, heroin, alcohol, or marijuana upon the taking of their drug of choice. Turning to the more exotic, a drug such as LSD may alter the way the world looks to us; it may even inspire thoughts of God. Adding to the purely scientific questions which confront us are the ways in which our society chooses to respond to the presence of psychoactive drugs. Should they be banned and their users sent to prison, tolerated as a reflection of man's eternal search for an escape from anxiety, pain, and the monotony of daily life, or celebrated as therapeutically useful agents? Our Love Affair with Drugs is written for experts and novices alike. There are stories of, for example, how Timothy Leary caused the repeal of the Marijuana Tax Act of 1937. Readers will learn of the transformation by Sir Charles Locock of a drug intended to dampen female sexual activity into the first effective drug for the treatment of the ancient disease of epilepsy. Alexander Shulgin's love of psychoactive drugs and his unconventional research practices illuminate the story of methylenedioxymethamphetamine, a.k.a. Ecstasy, a drug now likely to find value in treating veterans and others suffering post-traumatic distress disorder. Winter links the excitement of drug discovery with the very practical matter of balancing the benefits and risks of these drugs.
The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts
Authors: Wasson Christopher W. , Ross Rebecca. L. , Morton Ruth , Mankouri Jamel , Del Galdo Francesco 
Published: November 2020

Abstract

Objectives
Tissue fibrosis in SSc is driven by active fibroblasts (myofibroblasts). Previous studies have shown the intracellular chloride channel 4 (CLIC4) mediates the activation of cancer-associated fibroblasts. In this study we investigated the role of CLIC4 in SSc fibroblast activation.

Methods
Fibroblasts were obtained from full thickness skin biopsies from SSc patients (early-diffuse). RNA and protein were collected from the fibroblasts and CLIC4 transcript and protein levels were assessed by qPCR and western blot. SSc patient fibroblasts were treated with the chloride channel inhibitors nitro-2-(3-phenylpropylamino)benzoic acid and indyanyloxyacetic acid 94.

Results
CLIC4 was expressed at significantly higher levels in SSc patients’ fibroblasts compared with healthy controls, at both the transcript (3.7-fold) and protein (1.7-fold) levels. Inhibition of the TGF-β receptor and its downstream transcription factor SMAD3 led to a reduction in CLIC4 expression, confirming this pathway as the main driver of CLIC4 expression. Importantly, treatment of SSc fibroblasts with known pharmacological inhibitors of CLIC4 led to reduced expression of the myofibroblast markers collagen type 1 and α-smooth muscle actin, inferring a direct role for CLIC4 in disease pathogenesis.

Conclusions
We have identified a novel role for CLIC4 in SSc myofibroblast activation, which strengthens the similarities of SSc fibroblasts with cancer-associated fibroblasts and highlights this channel as a novel target for therapeutic intervention.
A potential role for zinc in restless legs syndrome
Authors: Chen Pan , Bornhorst Julia , Patton Stephanie , Bagai Kanika , Nitin Rachana , Miah Mahfuzur , Hare Dominic J , Kysenius Kai , Crouch Peter J , Xiong Lan , Rouleau Guy A , Schwerdtle Tanja , Connor James , Aschner Michael , Bowman Aaron B , Walters Arthur S 
Published: November 2020

Abstract

Study Objectives
Evaluate serum and brain noniron metals in the pathology and genetics of restless legs syndrome (RLS).

Methods
In two independent studies (cohorts 1 and 2), in which subjects either remained on medications or tapered off medications, we analyzed serum levels of iron, calcium, magnesium, manganese, copper, and zinc both in RLS patients and controls, and assessed the prevalence of the MEIS1 and BTBD9 risk alleles previously established through genome-wide association studies. Human brain sections and a nematode genetic model were also quantified for metal levels using mass spectrometry.

Results
We found a significant enrichment for the BTBD9 risk genotype in the RLS affected group compared to control (p = 0.0252), consistent with previous literature. Serum (p = 0.0458 and p = 0.0139 for study cohorts 1 and 2, respectively) and brain (p = 0.0413) zinc levels were significantly elevated in the RLS patients versus control subjects.

Conclusion
We show for the first time that serum and brain levels of zinc are elevated in RLS. Further, we confirm the BTBD9 genetic risk factor in a new population, although the zinc changes were not significantly associated with risk genotypes. Zinc and iron homeostasis are interrelated, and zinc biology impacts neurotransmitter systems previously linked to RLS. Given the modest albeit statistically significant increase in serum zinc of ~20%, and the lack of association with two known genetic risk factors, zinc may not represent a primary etiology for the syndrome. Further investigation into the pathogenetic role that zinc may play in restless legs syndrome is needed.
FromArgetoZenarge: adult morphology and phylogenetics of argid sawflies (Hymenoptera: Argidae)
Authors: Malagón-Aldana Leonardo A , Smith David R , Shinohara Akihiko , Vilhelmsen Lars 
Published: November 2020

AbstractThe Argidae is the second most diverse family of the ‘Symphyta’ with more than 900 described species. Here we present the first comprehensive phylogenetic study for the family. We compare the adult skeleton anatomy of representatives of 57 described argid genera from different biogeographic regions. We score 223 characters for 117 terminal taxa, and apply maximum parsimony inference to reconstruct the phylogeny, using equal weights and implied weights analyses. The Argidae sensu stricto, i.e. all Argidae except Zenarge, are consistently retrieved as monophyletic. The position of Zenarge changes according to the implied weighting parameters: ((Zenarge+Pergidae)+Argidae) at low (1–3) k-values, (Zenarge+(Pergidae+Argidae)) at high (4–30) k-values. We describe in detail the skeletal anatomy of Zenarge turneri and propose to raise it to family status: Zenargidae stat. revis. We consider the ridge on the teloparameres (=harpes) of the male genitalia to be the main autapomorphy of adults of the Argidae sensu stricto. We recover two main clades within the family and suggest recognizing these as the subfamilies Arginae and Sterictiphorinae. We trace the evolution of characters on the preferred implied weights tree. The genera Arge, Didymia, Pampsilota, Ptenos and Sphacophilus were paraphyletic.
Assessing Aerated Vermicompost Tea Combined with Microbial Biological Control Agents for Suppression of Fusarium and Rhizoctonia
Authors: Wylie Andrew C. , Punja Zamir K. 
Published: November 2020

Biological control of plant diseases is important in organic greenhouse vegetable production, where fungicide use is limited. Organic producers use microbially diverse substrates, including composts, as media for plant growth. Previous research into the impact of vermicompost on the efficacy of applied biocontrol agents is limited. An in vitro assay was developed to test the efficacy of two biological control agents in a competitive microbial background. Suppression of the pathogen Fusarium oxysporum f. sp. radicis-cucumerinum by Clonostachys rosea f. catenulata (Gliocladium catenulatum strain J1446 [Prestop]) and Bacillus subtilis strain QST 713 (Rhapsody), was assessed on agar media amended with aerated vermicompost tea (ACT). Pathogen growth was reduced more by C. rosea than ACT alone, and C. rosea was equally effective when combined with ACT. In contrast, B. subtilis reduced pathogen growth less than ACT and, when combined, reduced pathogen growth no more than ACT alone. Both biocontrol agents were similarly tested with ACT against F. oxysporum f. sp. radicis-cucumerinum and Rhizoctonia solani on cucumber and radish. Additive, neutral, and antagonistic responses, depending on host, pathogen, and biocontrol agent, were observed. ACT alone provided more consistent disease suppression on cucumber compared with B. subtilis or C. rosea. In combination, disease suppression was most often better than each biocontrol alone but not better than ACT alone. ACT had antagonistic or additive interactions with C. rosea in the radish/R. solani pathosystem, depending on the experiment. The specific and general suppression of plant diseases by biological control agents in microbially rich environments is variable and warrants further study.
Ballistic Supracondylar Distal Femur Fractures Have Lower Rates of Intra-articular Extension Than Blunt Distal Femur Fractures
Authors: Portney Daniel A. , Reddy Manoj , Baker Hayden P. , Dillman Daryl B. , Dirschl Douglas R. , Strelzow Jason A. 
Published: November 2020

Objectives:
To compare the relative frequencies of intra-articular extension of supracondylar distal femur fractures in blunt versus ballistic trauma and the diagnostic accuracy of conventional radiography in identifying intra-articular extension in these fractures.

Design:
A retrospective review.

Setting:
Urban academic trauma center.

Study group:
Thirty-eight patients were included for analysis, with 19 blunt and 19 ballistic mechanism distal femur fractures.

Intervention:
Fleiss' kappa score was calculated in determining interobserver reliability of the OTA/AO classification. Radiographic specificity and sensitivity were compared using Fischer exact testing. Quantitative data were compared using 2-tailed t-testing for continuous variables and chi-square tests for proportions.

Main outcome measurements:
Rate of intra-articular extension of ballistic versus blunt supracondylar femur fractures.

Results:
Seventeen of 19 patients (89.5%) with blunt trauma had intra-articular involvement compared with 5 of 19 patients (26.3%) with ballistic trauma (P = 0.001). For blunt fractures, preoperative radiographs were 94% sensitive for the detection of intra-articular extension compared with 100% sensitive for ballistic fractures (P = 1.000). We identified one case, in the blunt cohort, where the operative plan changed from intramedullary nail to open reduction and internal fixation as a result of the additional coronal plane fracture pattern identified on CT. There were no such occurrences in the ballistic cohort.

Conclusions:
The rate of intra-articular extension for ballistic supracondylar femur fractures is lower than blunt distal femur fracture. There were low rates of missed intra-articular fractures and changes in operative plans after reviewing CT imaging for both blunt and ballistic distal femur fractures.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Risk Factors for Deep Surgical Site Infection in Patients With Operatively Treated Tibial Plateau Fractures: A Retrospective Multicenter Study
Authors: Henkelmann Ralf , Frosch Karl-Heinz , Mende Meinhard , Gensior Tobias J. , Ull Christopher , Braun Philipp-Johannes , Katthagen Christoph , Glaab Richard , Hepp Pierre 
Published: November 2020

Objectives:
To identify the potential controllable risk factors for surgical site infection (SSI).

Design:
A retrospective cohort study.

Setting:
Seven Level-I trauma centers.

Patients/Participants:
Patients with OTA/AO 41 B or C tibial plateau fractures (n = 2106).

Intervention:
Various surgical treatments for tibial plateau fractures.

Main Outcome Measurements:
The primary outcome was SSI after the index operation. The secondary outcomes were the risk factors for SSI, identified using backward stepwise generalized multiple regression analysis.

Results:
Of the 2106 enrolled patients, 94 had deep SSIs. The average SSI rate was 4.5%. Fracture morphology revealed type B injuries in 57.5% and type C in 42.5% of the patients. Univariate regression analysis revealed that several factors, namely, number of comorbidities [>6 vs. none; odds ratio (OR) 8.01, 95% confidence interval (CI) 2.8–22.8, P < 0.001], diabetes mellitus (OR 3.5, 95% CI 2.0–6.3, P < 0.001), high body mass index (OR 1.3, 95% CI 1.1–1.6, P = 0.001), OTA/AO fracture type C (OR 5.6, 95% CI 3.3–9.5, P < 0.001), compartment syndrome (OR 9.1, 95% CI 5.7–14.8, P < 0.001), and open fracture (OR 6.6, 95% CI 3.7–11.7, P < 0.001), were associated with a significantly higher SSI risk. Analysis of microbial sensitivity tests revealed that 55.1% of the pathogens were resistant to perioperative antibiotic prophylaxis.

Conclusions:
Most of the identified risk factors cannot be controlled or are subject to other factors that are difficult to control. However, our data suggest that the choice of perioperative antibiotic prophylaxis may influence the rate of SSI. This possibility should be investigated in a prospective randomized controlled trial.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Epidemiology of Chronic Critical Illness in Japan: A Nationwide Inpatient Database Study
Authors: Ohbe Hiroyuki , Matsui Hiroki , Fushimi Kiyohide , Yasunaga Hideo 
Published: November 2020

OBJECTIVES:
The epidemiology of chronic critical illness is not well known. We aimed to estimate the prevalence, mortality, and costs associated with chronic critical illness in Japan.

DESIGN:
A nationwide inpatient administrative database study in Japan from April 2011 to March 2018.

SETTING:
Six hundred seventy-nine acute-care hospitals with ICU beds in Japan.

PATIENTS:
Adult patients who met our definition for chronic critical illness: one of six eligible clinical conditions (prolonged acute mechanical ventilation, tracheotomy, stroke, traumatic brain injury, sepsis, and severe wound) plus at least 8 consecutive days in an ICU.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Among 2,395,016 ICU admissions during the study period, 216,434 (9.0%) met the definition for chronic critical illness. The most common eligible condition was prolonged acute mechanical ventilation (73.9%), followed by sepsis (50.6%), tracheostomy (23.8%), and stroke (22.8%). Overall inhospital mortality was 28.6%. The overall age-specific population prevalence was 42.0 per 100,000. The age-specific population prevalence steadily increased with age, reaching 109.6 per 100,000 in persons aged greater than 85 years. With extrapolation to national estimates in Japan, there were 47,729 chronic critical illness cases in 2011 and the number remained similar at 46,494 cases in 2017. Hospitalization costs increased gradually, rising from U.S.$2.3 billion in 2011 to U.S.$2.7 billion in 2017. Inhospital mortality decreased from 30.6% to 28.2%, whereas the proportion of patients with total/severe dependence increased from 29.6% to 33.2% and the proportion of patients with decreased consciousness at discharge increased from 18.7% to 19.6%.

CONCLUSIONS:
Using a nationwide inpatient database in Japan, we found substantial clinical and economic burdens of chronic critical illness in Japan. Chronic critical illness was particularly common in elderly people. Although inhospital mortality of chronic critical illness patients continues to decrease, costs and patients with dependence for activities of daily living or decreased consciousness at discharge are increasing.