bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating Interfacial Stability Via Bilayer Heterostructure Solid Electrolyte Toward High‐energy, Safe and Adaptable Lithium Batteries
Authors: Sun Jianqi , Yao Xiangming , Li Yaogang , Zhang Qinghong , Hou Chengyi , Shi Qiuwei , Wang Hongzhi 
Published: June 2020

AbstractSolid‐state electrolytes are widely anticipated to enable the revival of high energy density and safe metallic Li batteries, however, their lower ionic conductivity at room temperature, stiff interfacial contact, and severe polarization during cycling continue to pose challenges in practical applications. Herein, a dual‐composite concept is applied to the design of a bilayer heterostructure solid electrolyte composed of Li+ conductive garnet nanowires (Li6.75La3Zr1.75Nb0.25O12)/polyvinylidene fluoride‐co‐hexafluoropropylene (PVDF‐HFP) as a tough matrix and modified metal organic framework particles/polyethylene oxide/PVDF‐HFP as an interfacial gel. The integral ionic conductivity of the solid electrolyte reaches 2.0 × 10−4 S cm−1 at room temperature. In addition, a chemically/electrochemically stable interface is rapidly formed, and Li dendrites are well restrained by a robust inorganic shield and matrix. As a result, steady Li plating/stripping for more than 1700 h at 0.25 mA cm−2 is achieved. Solid‐state batteries using this bilayer heterostructure solid electrolyte deliver promising battery performance (efficient capacity output and cycling stability) at ambient temperature (25 °C). Moreover, the pouch cells exhibit considerable flexibility in service and unexpected endurance under a series of extreme abuse tests including hitting with a nail, burning, immersion under water, and freezing in liquid nitrogen.
The Synergism of DMSO and Diethyl Ether for Highly Reproducible and Efficient MA0.5FA0.5PbI3 Perovskite Solar Cells
Authors: Zhang Yi , Chen Min , Zhou Yuanyuan , Li Wenhao , Lee Yonghui , Kanda Hiroyuki , Gao Xiao‐Xin , Hu Ruiyuan , Brooks Keith Gregory , Zia Rashid , Kinge Sachin , Padture Nitin P. , Nazeeruddin Mohammad Khaja 
Published: June 2020

AbstractComposition and film quality of perovskite are crucial for the further improvement of perovskite solar cells (PSCs), including efficiency, reproducibility, and stability. Here, it is demonstrated that by simply mixing 50% of formamidinium (FA+) into methylammonium lead iodide (MAPbI3), a highly crystalline, stable phase, and compact, polycrystalline grain morphology perovskite is formed by using a solvent‐mediated phase transformation process via the synergism of dimethyl sulfoxide and diethyl ether, which shows long carrier lifetime, low trap state density, and a record certified 21.8% power conversion efficiency (PCE) in pure‐iodide, alkaline‐metal‐free MA0.5FA0.5PbI3 perovskite‐based PSCs. These PSCs show very high operational stability, with 85% PCE retention upon 1000 h 1 Sun intensity illumination. A 17.33% PCE module (6.5 × 7 cm2) is also demonstrated, attesting to the scalability of such devices.
Regioselective Generation of Single‐Site Iridium Atoms and Their Evolution into Stabilized Subnanometric Iridium Clusters in MWW Zeolite
Authors: Liu Lichen , Lopez‐Haro Miguel , Meira Debora M. , Concepcion Patricia , Calvino Jose J. , Corma Avelino 
Published: June 2020

AbstractPreparation of supported metal catalysts with uniform particle size and coordination environment is a challenging and important topic in materials chemistry and catalysis. In this work, we report the regioselective generation of single‐site Ir atoms and their evolution into stabilized subnanometric Ir clusters in MWW zeolite, which are located at the 10MR window connecting the two neighboring 12MR supercages. The size of the subnanometric Ir clusters can be controlled by the post‐synthesis treatments and maintain below 1 nm even after being reduced at 650 °C, which cannot be readily achieved with samples prepared by conventional impregnation methods. The high structure sensitivity, size‐dependence, of catalytic performance in the alkane hydrogenolysis reaction of Ir clusters in the subnanometric regime is evidenced.
Beryllium Atom Mediated Dinitrogen Activation via Coupling with Carbon Monoxide
Authors: Deng Guohai , Pan Sudip , Wang Guanjun , Zhao Lili , Zhou Mingfei , Frenking Gernot 
Published: June 2020

AbstractThe reactions of laser‐ablated beryllium atoms with dinitrogen and carbon monoxide mixtures form the end‐on bonded NNBeCO and side‐on bonded (η2‐N2)BeCO isomers in solid argon, which are predicted by quantum chemical calculations to be almost isoenergetic. The end‐on bonded complex has a triplet ground state while the side‐on bonded isomer has a singlet electronic ground state. The complexes rearrange to the energetically lowest lying NBeNCO isomer upon visible light excitation, which is characterized to be an isocyanate complex of a nitrene derivative with a triplet electronic ground state. A bonding analysis using a charge‐ and energy decomposition procedure reveals that the electronic reference state of Be in the NNBeCO isomers has an 2s02p2 excited configuration and that the metal‐ligand bonds can be described in terms of N2→Be←CO σ donation and concomitant N2←Be→CO π backdonation. The results demonstrate that the activation of N2 with the N−N bond being completely cleaved can be achieved via coupling with carbon monoxide mediated by a main group atom.
Platinum‐ and CuOx‐Decorated TiO2 Photocatalyst for Oxidative Coupling of Methane to C2 Hydrocarbons in a Flow Reactor
Authors: Li Xiyi , Xie Jijia , Rao Heng , Wang Chao , Tang Junwang 
Published: June 2020

AbstractOxidative coupling of methane (OCM) is considered one of the most promising catalytic technologies to upgrade methane. However, C2 products (C2H6/C2H4) from conventional methane conversion have not been produced commercially owing to competition from overoxidation and carbon accumulation at high temperatures. Herein, we report the codeposition of Pt nanoparticles and CuOx clusters on TiO2 (PC‐50) and use of the resulting photocatalyst for OCM in a flow reactor operated at room temperature under atmospheric pressure for the first time. The optimized Cu0.1Pt0.5/PC‐50 sample showed a highest yield of C2 product of 6.8 μmol h−1 at a space velocity of 2400 h−1, more than twice the sum of the activity of Pt/PC‐50 (1.07 μmol h−1) and Cu/PC‐50 (1.9 μmol h−1), it might also be the highest among photocatalytic methane conversions reported so far under atmospheric pressure. A high C2 selectivity of 60 % is also comparable to that attainable by conventional high‐temperature (>943 K) thermal catalysis. It is proposed that Pt functions as an electron acceptor to facilitate charge separation, while holes could transfer to CuOx to avoid deep dehydrogenation and the overoxidation of C2 products.
Regenerable Covalent Organic Frameworks for Photo‐enhanced Uranium Adsorption from Seawater
Authors: Cui Wei‐Rong , Li Fang‐Fang , Xu Rui‐Han , Zhang Cheng‐Rong , Chen Xiao‐Rong , Yan Run‐Han , Liang Ru‐Ping , Qiu Jian‐Ding 
Published: June 2020

AbstractUranium is a key resource for the development of the nuclear industry, and extracting uranium from the natural seawater is one of the most promising ways to address the shortage of uranium resources. Herein, a semiconducting covalent organic framework (named NDA‐TN‐AO) with excellent photocatalytic and photoelectric activities was synthesized. The excellent photocatalytic effect endowed NDA‐TN‐AO with a high anti‐biofouling activity by generating biotoxic reactive oxygen species and promoting photoelectrons to reduce the adsorbed UVI to insoluble UIV, thereby increasing the uranium extraction capacity. Owing to the photoinduced effect, the adsorption capacity of NDA‐TN‐AO to uranium in seawater reaches 6.07 mg g−1, which is 1.33 times of that in dark. The NDA‐TN‐AO with enhanced adsorption capacity is a promising material for extracting uranium from the natural seawater.
Immunological Evaluation of Co‐Assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants: Self‐Adjuvanting Anti‐Breast‐Cancer Vaccine Candidates
Authors: Aiga Taku , Manabe Yoshiyuki , Ito Keita , Chang Tsung‐Che , Kabayama Kazuya , Ohshima Shino , Kametani Yoshie , Miura Ayane , Furukawa Hiroto , Inaba Hiroshi , Matsuura Kazunori , Fukase Koichi 
Published: June 2020

AbstractCo‐assembling vaccines composed of a lipidated HER2‐derived antigenic CH401 peptide and either a lipophilic adjuvant, Pam3CSK4, α‐GalCer, or lipid A 506, were evaluated as breast cancer vaccine candidates. This vaccine design was aimed to inherit both antigen multivalency and antigen‐specific immunostimulation properties, observed in reported self‐adjuvanting vaccine candidates, by using self‐assembly and adjuvant‐conjugated antigens. Under vaccination concentrations, respective lipophilic adjuvants underwent co‐assembly with lipidated CH401, which boosted the anti‐CH401 IgG and IgM production. In particular, α‐GalCer was responsible for the most significant immune activation. Therefore, the newly developed vaccine design enabled the optimization of adjuvants against the antigenic CH401 peptide in a simple preparatory manner. Overall, the co‐assembling vaccine design opens the door for efficient and practical self‐adjuvanting vaccine development.
Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non‐Covalent Chemistries
Authors: Morgese Giulia , de Waal Bas F. M. , Varela‐Aramburu Silvia , Palmans Anja R. A. , Albertazzi Lorenzo , Meijer E. W. 
Published: June 2020

AbstractUnderstanding cell/material interactions is essential to design functional cell‐responsive materials. While the scientific literature abounds with formulations of biomimetic materials, only a fraction of them focused on mechanisms of the molecular interactions between cells and material. To provide new knowledge on the strategies for materials/cell recognition and binding, supramolecular benzene‐1,3,5‐tricarboxamide copolymers bearing benzoxaborole moieties are anchored on the surface of human erythrocytes via benzoxaborole/sialic‐acid binding. This interaction based on both dynamic covalent and non‐covalent chemistries is visualized in real time by means of total internal reflection fluorescence microscopy. Exploiting this imaging method, we observe that the functional copolymers specifically interact with the cell surface. An optimal fiber affinity towards the cells as a function of benzoxaborole concentration demonstrates the crucial role of multivalency in these cell/material interactions.
Design, synthesis, and study of Pd(II) ion‐imprinted functionalized polymer
Authors: Nozari Mohammad , Monier Mohammed , Bashal Ali H. 
Published: June 2020

AbstractSelective metal ions’ extraction and recovery has various applications in the analytical field. Metal ions need to be extracted, detected, and quantified. For that purpose, ion‐imprinted polymers have earned a great deal of attention during the past two decades. Pd2+ ion‐imprinted hollow silica particles including an isatin Schiff base were prepared by Schiff base condensation of (3‐aminopropyl)triethoxysilane and isatin. The prepared Schiff base ligand was coordinated to the target Pd2+ cations, the polymerizable Pd‐complex was set aside to form gel in the company of tetraethoxysilane and the target Pd2+ cations were subsequently removed from the cross‐linked silica network by means of acidified thiourea solution. All materials throughout this synthesis process were investigated utilizing mass spectrometry, elemental analysis, FTIR, and 1H‐NMR. The morphological structure of both Pd2+ ion‐imprinted and non‐ion‐imprinted silica polymer were pictured by scanning electron microscopy. Several batches were studied exploiting both Pd2+ ion‐imprinted and non‐ion‐imprinted silica polymer to test their functionality for selective extraction of Pd2+ cations in multi‐ionic solution of Ni2+, Co2+, Cu2+, Mn2+, and Pd2+.
Ecofriendly synthesis of pyrano[2,3‐d]pyrimidine derivatives and related heterocycles with anti‐inflammatory activities
Authors: AbdEl‐Azim Mohamed H. M. , Aziz Maged A. , Mouneir Samar M. , EL‐Farargy Ahmed F. , Shehab Wesam S. 
Published: June 2020

AbstractA versatile, efficient, clean, and facile method was used for the synthesis of pyrano[2,3‐d]pyrimidine derivatives by the one‐pot three‐component condensation reaction of thiobarbituric acid and malononitrile with p‐chlorobenzaldehyde, using Fe3O4 or ZnO or Mn3O4 as nanostructure catalysts. The catalyst could be easily recovered using an external magnet and reused for six cycles with almost a consistent activity. A series of polyheterocyclic compounds containing five and/or six rings fused with each other was designed. The anti‐inflammatory activities for some of the newly synthesized compounds were evaluated. All the synthesized compounds were characterized on the basis of their elemental analyses and spectral data.
Astronomische Nachrichten—Broadband photometry of asteroid 6478 Gault: Activity and morphology
Authors: Borysenko Serhii , Baransky Alexander , Simon Andrii , Vasylenko Volodymyr 
Published: June 2020

AbstractWe present the results of a short observational program of asteroid 6478 Gault using ofVandRJohnson filters realized at the Kyiv Comet Station during January to April 2019. Color indices and distribution of brightness in the comet‐like tail were calculated. We conducted a comparative analysis of circumstances of the asteroid 6478 Gault activity with others morphologically similar active main‐belt asteroids.
Traces matter: Targeted optimization of monoclonal antibody N‐glycosylation based on/by implementing automated high‐throughput trace element screening
Authors: Markert Sven , Torkler Stephanie , Hohmann Katharina , Popp Oliver 
Published: June 2020

AbstractThe use of high‐throughput systems in cell culture process optimization offers various opportunities in biopharmaceutical process development. Here we describe the potential for acceleration and enhancement of product quality optimization and de novo bioprocess design regarding monoclonal antibody N‐glycosylation by using an iterative statistical Design of Experiments (DoE) strategy based on our automated microtiter plate‐based system for suspension cell culture. In our example, the combination of an initial screening of trace metal building blocks with a comprehensive DoE‐based screening of 13 different trace elemental ions at three concentration levels in one run revealed most effective levers for N‐glycan processing and biomass formation. Obtained results served to evaluate optimal concentration ranges and the right supplementation timing of relevant trace elements at shake flask and 2 L bioreactor scale. This setup identified manganese, copper, zinc, and iron as major factors. Manganese and copper acted as inverse key players in N‐glycosylation, showing a positive effect of manganese and a negative effect of copper on glycan maturation in a zinc‐dependent manner. Zinc and iron similarly improved cell growth and biomass formation. These findings allowed determining optimal concentration ranges for all four trace elements to establish control on desired product quality attributes regarding premature afucosylated and mature galactosylated glycan species. Our results demonstrates the power of combining robotics with DoE screening to enhance product quality optimization and to improve process understanding, thus, enabling targeted product quality control.
Splenic artery loops: Potential splenic plexus stimulation sites for neuroimmunomodulatory‐based anti‐inflammatory therapy?
Authors: Cleypool Cindy G. J. , Lotgerink Bruinenberg Dyonne , Roeling Tom , Irwin Eric , Bleys Ronald L. A. W. 
Published: June 2020

AbstractIntroductionThe splenic plexus might represent a novel neuroimmunomodulatory therapeutic target as electrical stimulation of this tissue has been shown to have beneficial anti‐inflammatory effects. Tortuous splenic artery segments (splenic artery loops), including their surrounding nerve plexus, have been evaluated as potential stimulation sites in humans. At present, however, our understanding of these loops and their surrounding nerve plexus is incomplete. This study aims to characterize the dimensions of these loops and their surrounding nerve tissue.Materials and MethodsSix formaldehyde fixed human cadavers were dissected and qualitative and quantitative macro‐ and microscopic data on splenic artery loops and their surrounding nerve plexus were collected.ResultsOne or multiple loops were observed in 83% of the studied specimens. These loops, including their surrounding nerve plexus could be easily dissected free circumferentially thereby providing sufficient space for further surgical intervention. The splenic plexus surrounding the loops contained a significant amount of nerves that contained predominantly sympathetic fibers.ConclusionThe results of this study support that splenic artery loops could represent suitable electrical splenic plexus stimulation sites in humans. Dimensions with respect to loop height and width, provide sufficient space for introduction of surgical instruments and electrode implantation, and, the dissected neurovascular bundles contain a substantial amount of sympathetic nerve tissue. This knowledge may contribute to further development of surgical techniques and neuroelectrode interface design.
Uridine phosphorylase 1 is a novel immune‐related target and predicts worse survival in brain glioma
Authors: Wang Jin , Xu Shihai , Lv Wen , Shi Fei , Mei Shanshan , Shan Aijun , Xu Jianzhong , Yang Ying 
Published: June 2020

AbstractUridine phosphorylase 1 (UPP1) has been reported as an oncogene in several malignancies. In glioma, the role of UPP1 remains unclear. This study was performed to explore its role in glioma at transcriptional level. Totally, 998 glioma patients with clinical data were enrolled, including 301 mRNA microarray data from Chinese Glioma Genome Atlas (CGGA) dataset and 697 RNAseq data from The Cancer Genome Atlas (TCGA) dataset. Statistical analysis was performed with R language. UPP1 expression level was positively correlated with WHO grade of glioma. UPP1 was significantly upregulated in mesenchymal subtype and could serve as a potential biomarker for this subtype. Based on most correlated genes of UPP1, Gene ontology analysis revealed that UPP1 was profoundly associated with immune and inflammatory response. Gene Sets Variation Analysis was further performed and showed that UPP1 was particularly correlated with MHC‐II and LCK, which were mainly associated with activities of antigen‐presenting cells and T cells. Moreover, UPP1 was found to be synergistic with various immune checkpoint members, especially with PD1 pathway and B7‐H3. Finally, Kaplan‐Meier curves revealed that higher UPP1 indicated significantly shorter survival for glioma patients. Taken together, UPP1 played an oncogenic role in glioma via suppressing tumor‐related immune response.
Orphan nuclear receptor RORγ confers doxorubicin resistance in prostate cancer
Authors: Gao Menghan , Guo Lang , Wang Hong , Huang Jialuo , Han Fanghai , Xiang Songtao , Wang Junjian 
Published: June 2020

AbstractProstate cancer (PCa) is a malignant tumor with an extremely high prevalence. Doxorubicin is the first‐line clinical treatment for castration‐resistant PCa. Clinically, relapse is almost inevitable due to the cancer cells' increasing resistance to doxorubicin. Our previous studies have revealed that retinoic acid‐related orphan nuclear receptor γ (RORγ) is a key protein for cancer progression and a promising target for PCa therapy. Though, RORγ's role and mechanism in doxorubicin‐resistant PCa remain unclear. To study the mechanism of doxorubicin resistance, we generated a doxorubicin‐resistant PCa cell line C4‐2B (C4‐2B DoxR) in this study, by culturing cells in an increasing doxorubicin concentration. Here, we show that RORγ expression was upregulated in C4‐2B DoxR cells compared with that in normal C4‐2B cells. The RORγ‐stably‐overexpressing PCa cell line constructed by lentiviral transfection showed an obvious improvement in doxorubicin resistance and a trend toward castration resistance. Furthermore, RORγ‐specific small molecule inhibitors XY018, GSK805, and SR2211 can significantly inhibit the proliferation of C4‐2B DoxR cells and promote their apoptosis. Collectively, these results have demonstrated the correlation between the upregulation of RORγ and the development of PCa's doxorubicin resistance, thus providing new ideas for solving the problem of chemotherapy drug resistance in PCa.
Developmental stages of zebrafish (Danio rerio) embryos and toxicological studies using foldscope microscope
Authors: Yesudhason Beryl Vedha , Selvan Christyraj Johnson Retnaraj Samuel , Ganesan Mijithra , Subbiahanadar Chelladurai Karthikeyan , Venkatachalam Saravanakumar , Ramalingam Arun , Benedict Johnson , Paulraj Vennila Devi , Selvan Christyraj Jackson Durairaj 
Published: June 2020

AbstractZebrafish (Danio rerio), is a well‐established vertebrate animal model widely used in developmental biology and toxicological research. In the present study, foldscope is used as an innovative tool to study the developmental stages and toxicological analysis of the zebrafish embryos. Briefly, the developmental stages, such as zygote, cleavage, blastula, gastrula, segmentation, and pharyngula formation are observed and documented using simple foldscope. Toxicological parameters upon exposure to different concentration of ethanol extract of Curcuma longa and its lead compound, ar‐turmerone along with rhodamine B (bio‐coupler) on zebrafish embryos are analyzed upto 72 hr using foldscopes in live condition. The lethal endpoints, such as coagulation, lack of somite formation, non‐detachment of tail, and lack of heartbeat are clearly monitored and documented using foldscope. Bio‐evaluation of test compounds with the aid of foldscope confirms that the toxicity is directly proportional to the concentration. Our results conclude that, ethanol extract of C. longa, ar‐turmerone and rhodamine B exposed embryos remains healthy up to 96, 48, and 24 µg concentrations, respectively. Embryos exposed to higher concentrations become coagulated, however normal physiological active movement of tail lashing and heartbeat are evident in lower concentration exposed embryos. Except coagulation, no other abnormalities are observed and interestingly, the hatching ability is not delayed, when compared with the control embryos. It is confirmed that the test compounds are not highly toxic to zebrafish embryos. Hence it can be used for further analysis, especially for studying the neural‐regeneration and its neuronal development in zebrafish embryos.
High‐Throughput Object Recognition and Sizing in Disperse Systems
Authors: Völp Annika Ricarda , Fessler Felix , Reiner Jasmin , Willenbacher Norbert 
Published: June 2020

AbstractSize and shape of dispersed objects defines properties of suspensions, emulsions, and foams, such as stability, texture, and flow. Accordingly, a rational product design requires reliable size distribution analysis. This is particularly challenging in dense foams. An endoscopic setup was optimized for bubble imaging minimizing light reflections, uneven illumination, and foam distortion. A software tool was developed detecting large quantities of foam bubbles at dispersed phase fractions up to 93 % from images with spatially varying contrast within minutes based on the template matching algorithm. Reliability of the method is also illustrated for a bimodal glass bead mixture, anisotropic nanocrystals, and emulsion droplets during freezing.