bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of robot technology in passive mobilization of acute hospitalized geriatric medicine patients: a pilot test and feasibility study
Authors: Bertelsen AS. , Storm A. , Minet L. , Ryg J. 
Published: January 2020

Abstract
Background
Along with an aging population, the field of robot technology in rehabilitation is expanding. As new technologies develop, it is important to test these clinically before implementation. To assess the possibilities of undertaking a future randomized controlled trial (RCT), the aim of this study was to pilot test and investigate the feasibility of a newly developed passive mobilization robot device in geriatric medicine patients.

Methods
We used a robot to perform passive mobilization for all recruited patients while they were lying in bed. Inclusion criteria include the following: ≥ 65 years of age, able to walk before hospitalization, and not capable of walking > 2 m at the first day of hospitalization. Exclusion criteria include the following: known moderate/severe dementia, unstable fractures (back, pelvis, or legs), high intracranial pressure, pressure ulcers/risk of developing pressure ulcers due to fragile skin, positive Confusion and Assessment Method (CAM) score, not able to understand Danish, and medical instability. A mixed-methods approach, including structured interviews for patients and relatives, questionnaires and semi-structured interviews for the staff, and observations in the clinic were used as data collection methods. A 6-week pilot test preceded the feasibility study to test study design, safety, interview guide, and setting, and to become familiar with the robot.

Results
The pilot test included 13 patients, made the staff confident in the use of the robot, and led to the correction of the interview guide. In the feasibility study, 177 patients were screened, 14 patients (four men, nine women) included, and 13 completed the intervention (median [IQR] age 86 [82–92] years). Overall, the robot was easy to use during passive mobilization and fully accepted by patients and relatives. Staff, however, found the robot difficult to maneuver. No adverse events were reported.

Conclusions
Use of robot technology in passive mobilization of older patients was feasible and well accepted by patients, relatives, and staff. Technical and workflow-related issues, as well as the robot not performing active mobilization, affects the launch of a RCT and thereby its implementation in geriatric medicine patients.
iTRAQ-based quantitative proteomics reveals a ferroptosis-like programmed cell death in plants infected by a highly virulent tobacco mosaic virus mutant 24A+UPD
Authors: Macharia Mercy , Das Prem P. , Naqvi Naweed I. , Wong Sek-Man 
Published: January 2020

AbstractPlants trigger a highly orchestrated defence mechanism in response to viral infection. In this study, we aimed at understanding the molecular events that lead to more accelerated cell death in Nicotiana benthamiana plants infected with the fast-replicating TMV 24A + UPD in comparison to TMV. TMV 24A + UPD is an artificial mutant that induces more severe symptoms leading to precocious death in plants. We employed the iTRAQ-based quantitative proteomics approach to identify and map the proteomes of TMV and TMV 24A + UPD infected plants at time points that correlate with initiation of early cell death symptoms. TMV 24A + UPD proteome profile revealed 183 highly abundant proteins versus 71 for TMV infected plants. KEGG analysis revealed differentially abundant proteins in the two proteome profiles under cell death, stress signalling, protein folding, sorting, degradation, transport and catabolism. We identified unique differentially abundant proteins in the TMV 24A + UPD profile, in particular under the ferroptosis and glutathione metabolism pathways. For validation, we varied the amount of intracellular iron by supplementing plants with Fe3+, employing iron chelators and by virus induced gene silencing of iron storage protein ferritin gene. We also employed potent ferroptosis inhibitors ferostatin-1, liprostatin-1, and transiently silenced glutathione peroxidase 4 gene. TMV 24A + UPD infected plants showed accelerated cell death symptoms when intracellular iron was increased. Decreasing intracellular iron protected the plants from accelerated cell death. We also observed a decrease in TMV 24A + UPD induced cell death when we applied ferroptosis inhibitors. Glutathione peroxidase 4 gene-silenced plants showed enhanced cell death compared to non-silenced control plants. Our study uncovered a link between intracellular iron and accelerated lipid ROS-induced cell death in TMV 24A + UPD infected plants. We propose that the fast-replicating mutant of TMV induces a distinct and potent form of cell death akin to ferroptosis.
Plant-based traditional foods and beverages of Ramotswa Village, Botswana
Authors: Bultosa Geremew , Molapisi Moenyane , Tselaesele Nelson , Kobue-Lekalake Rosemary , Desse Haki Gulelat , Makhabu Shimane , Sekwati-Monang Bonno , Seifu Eyassu , P. Nthoiwa Gothatamang 
Published: January 2020

AbstractBackground and objectivesDifferent communities have various types of edible plants at their nearby ecology from which they process their traditional foods that make the basis of diversified diets for food and nutrition security. Exploration of various ethnic traditional foods knowledge will have an immense contribution for preservation and sustainability of the traditional food system and culture. The objectives of this research were to investigate and document the edible plant type used and description on the processing of plant-based traditional foods/dishes and beverages of the Ramotswa village, Botswana. Majority of the Ramotswa village residents belong to the Balete tribe.MethodologyQuestionnaire interviews and focus group discussions (FGD) were used in the documentations of edible plants type, methods involved in the processing, values, challenges, and the seasonal availability.Results and discussionThere are 50 wild edible plants used and most are available during rainy season. Maize, sorghum, beans, cooking melon, watermelon, and pumpkin are widely used domesticated crops. The edible part of wild plants is utilized in different ways. Some consumed after minor processing and some as cooked, boiled, recipe in traditional dishes, inoculum in fermentation, substrate in traditional beverages, and medicinal plants. Food safety concerns were indicated for few products. High temperature and shortage of rainfall are making some edible plants scarce. For some, preparation takes a long time; and when processing is not properly done, unpleasant odor, bitter taste, and mold growth can result, particularly for traditional beverages. Even though, most traditional foods/dishes and beverages are still consumed and enjoyed by the communities, there are worries that the young generation has limited knowledge and skills to process and utilize them.ConclusionsMost plant-based traditional foods/dishes consumed are low in sugar and fat, but are wholesome (whole grains, with dietary fibers) with high potential for diet diversification. The documentation provided will help to create awareness for preservation of the traditional foods/dishes and beverage culture, and as a baseline information for further studies for those nutrient and bioactive compound data are not available.
Regional analysis of UK primary care prescribing and adult service referrals for young people with attention-deficit hyperactivity disorder
Authors: Price Anna , Ford Tamsin , Janssens Astrid , Williams Andrew James , Newlove-Delgado Tamsin 
Published: January 2020

Background
Approximately 20% of children with attention-deficit hyperactivity disorder (ADHD) experience clinical levels of impairment into adulthood. In the UK, there is a sharp reduction in ADHD drug prescribing over the period of transition from child to adult services, which is higher than expected given estimates of ADHD persistence, and may be linked to difficulties in accessing adult services. Little is currently known about geographical variations in prescribing and how this may relate to service access.

Aims
To analyse geographic variations in primary care prescribing of ADHD medications over the transition period (age 16–19 years) and adult mental health service (AMHS) referrals, and illustrate their relationship with UK adult ADHD service locations.

Method
Using a Clinical Practice Research Datalink cohort of people with an ADHD diagnosis aged 10–20 in 2005 (study period 2005–2013; n = 9390, 99% diagnosed <18 years), regional data on ADHD prescribing over the transition period and AMHS referrals, were mapped against adult ADHD services identified in a linked mapping study.

Results
Differences were found by region in the mean age at cessation of ADHD prescribing, range 15.8–17.4 years (P<0.001), as well as in referral rates to AMHSs, range 4–21% (P<0.001). There was no obvious relationship between service provision and prescribing variation.

Conclusions
Clear regional differences were found in primary care prescribing over the transition period and in referrals to AMHSs. Taken together with service mapping, this suggests inequitable provision and is important information for those who commission and deliver services for adults with ADHD.
Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerisation
Authors: Palumbo Valeria , Tariq Ammarah , Borgal Lori , Metz Jeremy , Brancaccio Mara , Gatti Maurizio , Wakefield James G. , Bonaccorsi Silvia 
Published: January 2020

ABSTRACT
Morgana (Mora, also known as CHORD in flies) and its mammalian homologue, called CHORDC1 or CHP1, is a highly conserved cysteine and histidine-rich domain (CHORD)-containing protein that has been proposed to function as an Hsp90 co-chaperone. Morgana deregulation promotes carcinogenesis in both mice and humans while, in Drosophila, loss of mora causes lethality and a complex mitotic phenotype that is rescued by a human morgana transgene. Here, we show that Drosophila Mora localises to mitotic spindles and co-purifies with the Hsp90–R2TP–TTT supercomplex and with additional well-known Hsp90 co-chaperones. Acute inhibition of Mora function in the early embryo results in a dramatic reduction in centrosomal microtubule stability, leading to small spindles nucleated from mitotic chromatin. Purified Mora binds to microtubules directly and promotes microtubule polymerisation in vitro, suggesting that Mora directly regulates spindle dynamics independently of its Hsp90 co-chaperone role.
AJoin
Authors: Karimov Jeyhun , Rabl Tilmann , Markl Volker 
Published: January 2020

The processing model of state-of-the-art stream processing engines is designed to execute long-running queries one at a time. However, with the advance of cloud technologies and multi-tenant systems, multiple users share the same cloud for stream query processing. This results in many ad-hoc stream queries sharing common stream sources. Many of these queries include joins.
There are two main limitations that hinder performing ad-hoc stream join processing. The first limitation is missed optimization potential both in stream data processing and query optimization layers. The second limitation is the lack of dynamicity in query execution plans.
We present AJoin, a dynamic and incremental ad-hoc stream join framework. AJoin consists of an optimization layer and a stream data processing layer. The optimization layer periodically reoptimizes the query execution plan, performing join reordering and vertical and horizontal scaling at run-time without stopping the execution. The data processing layer implements pipelineparallel join architecture. This layer enables incremental and consistent query processing supporting all the actions triggered by the optimizer. We implement AJoin on top of Apache Flink, an open-source data processing framework. AJoin outperforms Flink not only at ad-hoc multi-query workloads but also at single-query workloads.
Planting trees for scalable and efficient canonical hub labeling
Authors: Lakhotia Kartik , Kannan Rajgopal , Dong Qing , Prasanna Viktor 
Published: January 2020

Hub labeling is widely used to improve the latency and throughput of Point-to-Point Shortest Distance (PPSD) queries in graph databases. However, constructing hub labeling, even via the state-of-the-art Pruned Landmark Labeling (PLL) algorithm is computationally intensive. PLL further has a sequential root order label dependency that makes it challenging to parallelize. Hence, the existing parallel approaches are often plagued by label size increase, poor scalability and inability to process large weighted graphs.

In this paper, we develop novel algorithms that construct the minimal (guaranteed) Canonical Hub Labeling on shared and distributed-memory parallel systems in a scalable and efficient manner. Our key contribution, the PLaNT algorithm, provides an
embarrassingly parallel
approach for label construction that scales well beyond the limits of current practice. Our approach
is the first
to employ a collaborative label partitioning scheme across multiple nodes of a cluster, for completely in-memory labeling and parallel querying on massive graphs whose labels cannot fit on a single node.

On a single node with 72-threads, our shared-memory algorithm is up to 47.4X faster than sequential PLL. While our labeling time is comparable to the state-of-the-art shared-memory paraPLL, our label size is 17% smaller on average.
PLaNT demonstrates superior parallel scalability. It can process significantly larger graphs and construct labeling orders of magnitude faster than the state-of-the-art distributed paraPLL. Compared to the best shared-memory parallel algorithm, it achieves up to 9.5X speedup on a 64 node cluster.
Mass tourism in protected areas – underestimated threat? Polish National Parks case study
Authors: Widawski Krzysztof , Jary Zdzisław 
Published: January 2020

Abstract
The article considers the tourist traffic as possible to elements of inanimate nature in protected areas. The highest form of protection in Poland - national parks, has been taken into account. The main goal is to diagnose the situation based on the analysis of official documents elaborated by the national park authorities. One of the important elements is to diagnose the threat to nature and indicate ways to neutralize it. At the beginning, the geotouristic potential of these parks was presented, where this type of resources is considered important from the point of view of tourism. The tourist function of the most important attractions in Poland was indicated. In the top ten there are as many as 4 national parks, including Tatrzański which takes first place. The size of tourist traffic in all 23 parks was analyzed. As a result, it was shown that the most popular, where tourist flow is of mass character, include mountain parks with significant geotouristic potential. Next, the current protection plans for them were analyzed: Tatrzański, Karkonoski, Table Mountains and Pieniński, where the annual tourist flow varies between 0.5 million and almost 4 million visitors per year. Threats were assigned to 4 groups: existing internal threats, potential internal threats, existing external threats and potential external threats. In each of the types of threats special attention was paid to those related to inanimate nature. It also indicated the ways in which park managers want to influence the change of negative trends. The basic conclusion was indicated, which boils down to the postulate of a balanced approach to the protection of both types of nature: animate and inanimate. In the case of animate nature, threats and suggestions for improving the situation seem to be much better diagnosed than in the case of inanimate nature.
PEDAGOGICAL CONTENT KNOWLEDGE (PCK) ABILITY OF PRE SERVICE BIOLOGICAL TEACHERS BASED ON LESSON PLAN AND TEACHING PRACTICE
Authors: Situmorang Risya Pramana 
Published: January 2020

PEDAGOGICAL CONTENT KNOWLEDGE (PCK) KEMAMPUAN GURU BIASA PRA PELAYANAN BERBASIS RENCANA PELAJARAN DAN PRAKTEK PENGAJARAN AbstrakPenelitian ini mengidentifikasi empat aspek berbeda dari pengetahuan pedagogi dan tiga aspek dari pengetahuan materi, serta terkait di antara aspek-aspek PCK. Penelitian ini menunjukkan bahwa skor PCK calon guru biologi dalam menyusun rencana pelajaran dan praktik mengajar berada dalam kategori baik, dengan hasil persentase skor CK 70,83% (baik), hasil persentase skor PK 75,70% (baik), dan hasil persentase skor PCK 66,67% (sangat baik). Temuan dalam penelitian ini adalah kemampuan smahasiswa calon guru mulai berkembang mengenai PCK melalui cara penyampaian materi pelajaran biologi dengan menghargai ide-ide siswa sebelumnya dalam pembelajaran, meskipun kedalaman pemahaman bervariasi. Selain itu, hasil PCK menunjukkan banyak perkembangan dalam perancangan rencana pelajaran melalui pengetahuan konstruktivis. Pengembangan terhadap pengetahuan pedagogi, konten dan PCK berkaitan dengan keterampilan mengajar merupakan aspek yang sangat penting. Penggunaan rencana pelajaran yang mudah diakses dapat meningkatkan kemampuan PCK untuk mengembangkan prinsip-prinsip pedagogis. Meskipun pengembangan konten dan PCK terkait pedagogis, mungkin cukup untuk memungkinkan mahasiswa calon guru untuk membuat dan menghubungkan konteks materi pelajaran biologi yang memfasilitasi siswa dalam pembelajaran kontekstual. AbstractThis study identified four distinct aspects of pedagogical knowledge and three aspects of content knowledge, as well as related among these PCK aspects. This study shows that the PCK scores of pre service biology teachers in preparing lesson plan and teaching practice are in good category, with result of CK score percentage 70.83% (good), result of PK score percentage 75.70% (good), and result of PCK score percentage 66.67% (very good). Finding in this study were pre service students ability about PCK began to develop an understanding of the way to deliver biology subject material that values students’ prior ideas in learning, eventhough the depth of this understanding varied. In addition, PCK show as much growth in their lesson plan with respect to the constructing knowledge. In developing a pedagogy and content knowledge of PCK, relating to skills about teaching, appears to be critical. Using lesson plan that is simple accessible seems to increase PCK ability to develop pedagogical principles. Although development of content and pedagogical related PCK, it may be enough to allow pre-service student to create and relate the biology subject material contexts that facilitate students in contextual learning.
PENERAPAN BAHAN AJAR BERBASIS POTENSI LOKAL EKOSISTEM MANGROVE PONDOK BALI UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KREATIF
Authors: Sriyati Siti , Rimbun Wahyu , Amprasto Amprasto 
Published: January 2020

IMPROVEMENT OF CREATIVE THINKING BY TEACHING MATERIALS BASED ON LOCAL POTENTIAL OF PONDOK BALI MANGROVE AbstractThe mangrove ecosystem of Pondok Bali in Subang can be used as a learning resource in the form of contextual teaching materials for students around it. This study aims to apply teaching materials based on the local potential of Pondok Bali Subang mangrove ecosystem to improve students' creative thinking skills. This study uses a pre-experimental design method. The research subjects were class XI Fisheries Department with a total of 17 students.The instruments in the study included teaching materials based on the local potential of mangrove ecosystems, questions of creative thinking and student response questionnaires. Teaching materials based on local potential mangrove ecosystems were developed first and tested for their feasibility and readability before being used by students. Teaching materials are equipped with practice questions that explore students' creative thinking abilities. The results showed an increase in students' creative thinking skills before and after the application of teaching materials was applied. N-gain values of the indicators of creative thinking are consecutive: fluency, flexibility, originality and elaboration are 0.41, 0.54, 0.44 and 0.55 which are in the medium category. The increase in N-gain is: 23.5% of students in the high category, 58.8% in the medium category, 11.8% in the low category and 5.9% in no increase. Student responses to teaching materials showed a positive response (93.9%). AbstrakEkosistem mangrove Pondok Bali di Subang dapat dijadikan sumber belajar dalam bentuk bahan ajar yang kontektual bagi siswa-siswa di sekitarnya. Penelitian ini bertujuan untuk menerapkan bahan ajar berbasis potensi lokal ekosistem mangrove Pondok Bali Subang untuk meningkatkan kemampuan berpikir kreatif siswa. Penelitian ini menggunakan metode pre-experimental design. Subjek penelitian adalah siswa kelas XI Jurusan Perikanan dengan jumlah siswa sebanyak 17 orang. Instrumen pada penelitian meliputi bahan ajar berbasis potensi lokal ekosistem mangrove, soal berpikir kreatif dan angket respon siswa. Bahan ajar berbasis potensi lokal ekosistem mangrove disusun terlebih dahulu dan diuji kelayakan serta keterbacaannya sebelum digunakan oleh siswa. Bahan ajar dilengkapi dengan pertanyaan-pertanyaan latihan yang menggali kemampuan berpikir kreatif siswa. Hasil penelitian menunjukkan terjadi peningkatan kemampuan berpikir kreatif siswa sebelum dan sesudah diterapkan bahan ajar. Berturut-turut nilai N-gain dari indikator berpikir kreatif: fluency, flexibility, originality dan elaboration adalah 0,41, 0,54, 0,44 dan 0,55 yang termasuk kategori sedang. Peningkatan N-gainnya adalah: 23,5% siswa berkategori tinggi, 58,8% berkategori sedang, 11,8% berkategori rendah dan 5,9% tidak mengalami peningkatan. Tanggapan siswa terhadap bahan ajar menunjukkan respon yang positif (93,9%).
PENGGUNAAN MEDIA ONLINE DALAM PROYEK PEMBUATAN BAHAN AJAR BERBASIS WEB PADA MATA KULIAH ZOOLOGI VERTEBRATA
Authors: Susanti Baiq Hana 
Published: January 2020

DEVELOPMENT WEB BASED TEACHING MATERIALS ON VERTEBRATE CONCEPT AbstractThe study aimed to determine the profile of online media used in project web-based teaching materials in the Vertebrate Zoology course. This research was conducted on Biology Education program in the odd semester of academic year 2015/2016. The subject of this research is the students of Biology education program which in the odd semester take the Vertebrata Zoology courses totaling 25 people. The method used in the research is development with research design which consists of preliminary, development, and evaluation stage. Instrument in this research is in the form of evaluation material sheet by evaluator. The results showed that the average value given by the evaluator was 83, which entered into good category. Teaching materials developed by students vary widely. The teaching materials consist of wordpress (28%), wix (24%), webnode (16%), prezi (16%), other web and UIN Website respectively by 8%. This shows that students have been able to develop web-based teaching materials by utilizing the development of ICT. AbstrakPenelitian bertujuan untuk mendapatkan gambaran mengenai penggunaan media online dalam proyek pembuatan bahan ajar berbasis web pada matakuliah Zoology Vertebrata. Penelitian ini dilakukan pada program studi Pendidikan Biologi pada semester ganjil tahun ajaran 2015/2016. Subjek penelitian ini adalah mahasiswa program studi pendidikan Biologi yang pada semester ganjil mengambil mata kuliah Zoologi Vertebrata berjumlah 25 orang. Metode yang digunakan dalam penelitian adalah metode pengembangan dengan design penelitian terdiri dari tahap pendahuluan, pengembangan, dan evaluasi. Instrumen dalam penelitian ini berupa lembar penilaian bahan ajar oleh evaluator. Hasil penelitian menunjukkan nilai rata-rata yang diberikan oleh evaluator mendapatkan nilai 83 yang masuk kedalam kategori baik. Bahan ajar yang dikembangkan oleh mahasiswa sangat bervariasi. Bahan ajar tersebut terdiri dari wordpress (28%), wix (24%), webnode (16%), prezi (16%), web lainnya dan Website UIN masing masing sebesar 8%. Hal ini menunjukkan mahasiswa sudah mampu mengembangkan bahan ajar berbasis web dengan memanfaatkan perkembangan TIK.