bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Borderline Resectability in Pancreatic Head Cancer on Patient Survival: Biology Matters According to the New International Consensus Criteria
Authors: Anger Friedrich , Döring Anna , van Dam Jacob , Lock Johan Friso , Klein Ingo , Bittrich Max , Germer Christoph-Thomas , Wiegering Armin , Kunzmann Volker , van Eijck Casper , Löb Stefan 
Published: September 2020

Abstract
Background
International consensus criteria (ICC) have redefined borderline resectability for pancreatic ductal adenocarcinoma (PDAC) according to three dimensions: anatomical (BR-A), biological (BR-B), and conditional (BR-C). The present definition acknowledges that resectability is not just about the anatomic relationship between the tumour and vessels but that biological and conditional dimensions also are important.

Methods
Patients’ tumours were retrospectively defined borderline resectable according to ICC. The study cohort was grouped into either BR-A or BR-B and compared with patients considered primarily resectable (R). Differences in postoperative complications, pathological reports, overall (OS), and disease-free survival were assessed.

Results
A total of 345 patients underwent resection for PDAC. By applying ICC in routine preoperative assessment, 30 patients were classified as stage BR-A and 62 patients as stage BR-B. In total, 253 patients were considered R. The cohort did not contain BR-C patients. No differences in postoperative complications were detected. Median OS was significantly shorter in BR-A (15 months) and BR-B (12 months) compared with R (20 months) patients (BR-A vs. R: p = 0.09 and BR-B vs. R: p < 0.001). CA19-9, as the determining factor of BR-B patients, turned out to be an independent prognostic risk factor for OS.

Conclusions
Preoperative staging defining surgical resectability in PDAC according to ICC is crucial for patient survival. Patients with PDAC BR-B should be considered for multimodal neoadjuvant therapy even if considered anatomically resectable.
Elite Athletes and Pregnancy Outcomes: A Systematic Review and Meta-analysis
Authors: WOWDZIA JENNA B. , MCHUGH TARA-LEIGH , THORNTON JANE , SIVAK ALLISON , MOTTOLA MICHELLE F. , DAVENPORT MARGIE H. 
Published: September 2020

ABSTRACT

Purpose
The purpose of this systematic review was to evaluate fetal and maternal pregnancy outcomes of elite athletes who had participated in competitive sport immediately before conception.

Methods
Online databases were searched up to March 24, 2020. Studies of any design and language were eligible if they contained information on the relevant population (pregnant women), exposure (engaged in elite sport immediately before pregnancy), and outcomes (birth weight, low birth weight, macrosomia, preterm birth, fetal heart rate and pulse index, cesarean sections, instrumental deliveries, episiotomies, duration of labor, perineal tears, pregnancy-induced low back pain, pelvic girdle pain, urinary incontinence, miscarriages, prenatal weight gain, inadequate/excess prenatal weight gain, maternal depression or anxiety).

Results
Eleven unique studies (n = 2256 women) were included. We identified “low” certainty evidence demonstrating lower rates of low back pain in elite athletes compared with active/sedentary controls (n = 248; odds ratio, 0.38; 95% confidence interval, 0.20–0.73; I
2 = 0%) and “very low” certainty evidence indicating an increased odds of excessive prenatal weight gain in elite athletes versus active/sedentary controls (n = 1763; odds ratio, 2.47; 95% confidence interval, 1.26–4.85; I
2 = 0%). Low certainty evidence from two studies (n = 7) indicated three episodes of fetal bradycardia after high-intensity exercise that resolved within 10 min of cessation of activity. No studies reported inadequate gestational weight gain or maternal depression or anxiety. There were no differences between elite athletes and controls for all other outcomes.

Conclusions
There is “low” certainty of evidence that elite athletes have reduced odds of experiencing pregnancy-related low back pain and “very low”certainty of evidence that elite athletes have increased the odds of excessive weight gain compared with active/sedentary controls. More research is needed to provide strong evidence of how elite competitive sport before pregnancy affects maternal and fetal outcomes.
PROSPERO Registration: CRD42020167382.
Interrupting Prolonged Sitting and Endothelial Function in Polycystic Ovary Syndrome
Authors: TAYLOR FRANCES C. , DUNSTAN DAVID W. , FLETCHER ELLY , TOWNSEND MELANIE K. , LARSEN ROBYN N. , RICKARDS KYM , MANIAR NIRAV , BUMAN MATTHEW , DEMPSEY PADDY C. , JOHAM ANJU E. , COHEN NEALE , OWEN NEVILLE , MORAN LISA J. , GREEN DANIEL J. 
Published: September 2020

ABSTRACT

Purpose
In healthy adults, the impairment of vascular function associated with prolonged sitting can be mitigated with intermittent brief bouts of activity. It is unknown whether these benefits extend to women with polycystic ovary syndrome (PCOS), in whom vascular function is typically impaired and sitting time is high. We examined the acute effect of regularly interrupting sitting time with brief simple resistance activities (SRA) on vascular function in PCOS.

Methods
In a randomized crossover trial, 13 physically inactive women with PCOS (18–45 yr) completed two 3.5-h conditions: 1) uninterrupted sitting (SIT) and 2) sitting interrupted by 3-min bouts of SRA every 30 min. Femoral artery flow-mediated dilation (FMD), resting shear rate, and resting blood flow were measured at 0, 1, and 3.5 h.

Results
Mean resting femoral shear rate, averaged across the 3.5 h, significantly increased in the SRA condition relative to the SIT condition (40.1 ± 6.1 vs 62.8 ± 6.1 s−1, P < 0.0001). In addition, mean resting blood flow also significantly increased across the 3.5 h for SRA relative to SIT (45.0 ± 9.8 vs 72.8 ± 9.9 mL·min−1, P < 0.0001). There were no differences between conditions in the temporal change in femoral artery FMD across 3.5 h (P
time–condition > 0.05 for all).

Conclusion
Frequently interrupting sitting with SRA acutely increased resting shear rate and blood flow in women with PCOS but did not alter FMD. With sedentary behavior increasing in prevalence, longer-term studies of similar interventions to reduce and break up sitting time are warranted.
Seasonal Changes in Lumbar Multifidus Muscle in University Rugby Players
Authors: ROY ALEXANDRE , RIVAZ HASSAN , RIZK AMANDA , FRENETTE STEPHANE , BOILY MATHIEU , FORTIN MARYSE 
Published: September 2020

ABSTRACT

Purpose
Although smaller lumbar multifidus muscle (LMM) was reported to be a strong predictor of lower limb injury (LLI) in Australian Football League players, LMM morphology has not been investigated in rugby athletes. This study examined seasonal changes in LMM in rugby players and whether LMM characteristics were associated with low back pain (LBP) and LLI.

Methods
Ultrasound examinations of the LMM were acquired in 21 university-level rugby players (12 women, 9 men) at preseason and end-season. LMM cross-sectional area (CSA), thickness at rest, and thickness during submaximal contraction (e.g., contralateral arm lift) measurements in prone and standing were obtained bilaterally at the L5–S1 level. The percent change in LMM thickness during contraction was calculated as follows: [(thicknesscontracted − thicknessrest)/thicknessrest × 100]. Self-reported questionnaires were used to acquire data on LBP and LLI.

Results
There was no significant difference in LMM characteristics between preseason and end-season measurements (P > 0.05). Preseason LMM CSA, side-to-side CSA asymmetry, and thickness at rest or during contraction were not associated with LBP or LLI. However, a lower percent thickness change in the standing position was significantly associated with having LBP during the preseason (P = 0.01) and playing season (P = 0.001), as well as LLI during the preseason (P = 0.03).

Conclusions
This study provides preliminary evidence that LMM contractile ability and behavior during functional movement, such as standing, may have important implications for the susceptibility to injury among rugby athletes.
A Low-Calorie Diet with or without Exercise Reduces Postprandial Aortic Waveform in Females with Obesity
Authors: HEISTON EMILY M. , GILBERTSON NICOLE M. , EICHNER NATALIE Z. M. , MALIN STEVEN K. 
Published: September 2020

ABSTRACT

Purpose
Arterial stiffness is considered a predictor of cardiovascular disease. Females have higher values of arterial stiffness than males, suggesting a greater risk of heart-related complications. Although a low-calorie diet (LCD) reduces fasting arterial stiffness, in part through weight loss, it is unknown if interval exercise (INT) adds to the benefit of LCD on fasting and postprandial arterial stiffness in females with obesity.

Methods
Twenty-five females (47 ± 2.6 yr, 37.6 ± 1.3 kg·m−2) were randomized to 13 d of LCD (n = 12; mixed meals of ~1200 kcal·d−1) or LCD + INT (n = 13; 60 min·d−1 of supervised 3-min intervals at 90% HRpeak and 50% HRpeak). Arterial stiffness (augmentation index [AIx] and carotid–femoral pulse wave velocity [cfPWV]) and blood biochemistries were measured during a 75-g oral glucose tolerance test before and after the intervention to determine fasting and postprandial arterial stiffness as well as insulin sensitivity (simple index of insulin sensitivity [SIIS]) and inflammation (C-reactive protein, interleukin 8, and tumor necrosis factor alpha).

Results
Although LCD + INT increased V˙O2peak and HDL compared with LCD (P = 0.04 and P < 0.01, respectively), both interventions decreased body fat, LDL, total cholesterol, and triglycerides (all P < 0.01) and increased SIIS (P = 0.03). Despite no effect on fasting AIx (P = 0.27), LCD and LCD + INT decreased AIx60min (−7.4% ± 4.3% vs −7.0% ± 5.0%, P = 0.04) and tAUC120min (−663 ± 263 vs −457 ± 406, P = 0.03). There were no changes in fasting cfPWV (P = 0.91) or cfPWV120min (P = 0.62). Increased SIIS and decreased interleukin 8 were associated with reduced fasting AIx (r = −0.44, P = 0.03, and r = 0.40, P = 0.055), whereas decreased C-reactive protein correlated with reduced postprandial AIx60min (r = 0.43, P = 0.04).

Conclusion
Independent of exercise, 13 d of LCD reduces postprandial AIx in females with obesity. Insulin sensitivity and inflammation correlated with improved arterial stiffness, suggesting unique mechanisms regulate fasted versus postprandial arterial stiffness.
Letting Art Teach: Art Education ‘After’ Joseph Beuys, Gert Biesta (2017)
Authors: Heaton Rebecca 
Published: September 2020

Review of: Letting Art Teach: Art Education ‘After’ Joseph Beuys, Gert Biesta (2017)
Arnhem and Amsterdam: ArtEZ Press, 125 pp.,
ISBN 978-9-49144-437-1, h/bk, £27.00
Teaching and Learning in Art Education: Cultivating Students’ Potential from Pre-K through High School, D. Sickler-Voigth (2020)
Authors: Pavlou Victoria 
Published: September 2020

Review of: Teaching and Learning in Art Education: Cultivating Students’ Potential from Pre-K through High School, D. Sickler-Voigth (2020)
New York and London: Routledge, 438 pp.,
ISBN 978-1-13854-931-9, h/bk, £104.00
Calatonia: A Therapeutic Approach That Promotes Somatic and Psychological Regulation, Anita Ribeiro Blanchard, Ana Maria Galrão Rios and Leda Maria Perillo Seixas (eds) (2019)
Authors: Borges da Costa Ana Lucia 
Published: September 2020

Review of: Calatonia: A Therapeutic Approach That Promotes Somatic and Psychological Regulation, Anita Ribeiro Blanchard, Ana Maria Galrão Rios and Leda Maria Perillo Seixas (eds) (2019)
Miami: Alma Street Enterprise, 325 pp.,
ISBN 978-1-09791-435-7, p/bk, £8.93, Kindle, £7.07
Development of Automated Model Generation and Analysis of Surface-Cracked Plates in Bending for Interpolated Elastic–PlasticJ-Integral Solutions
Authors: Renfro Michael W. , Allen Phillip A. , Wilson Christopher D. 
Published: September 2020

AbstractNASA’s Tool for Analysis of Surface Cracks (TASC) has been used since 2014 to perform elastic–plastic J-integral (J), crack mouth opening displacement (CMOD), crack front constraint, and deformation limit calculations for plates in tension. To date, no comparable database or tool exists for surface-cracked plates in bending. Existing tools and prior ASTM standards are limited to linear-elastic materials or simpler 2-D crack geometries. TASC uses a database of 600 models for interpolated solutions over a wide range of semielliptical surface crack geometries (0.2≤a/c≤1.0, 0.2≤a/t≤0.8) and material properties (100≤E/Sys≤1,000, 3≤n≤20). Here, a is the crack depth, c is the half-width of the crack, and t is the plate thickness, so that a/c is the crack aspect ratio and a/t is a normalized measurement of crack depth. E, Sys, and n are the plate’s elastic modulus, yield strength, and the Ramberg–Osgood power law hardening exponent, respectively. This report details the development of a bending model database covering the same range of crack geometries and material properties. It includes developing new criteria to determine if a model has reached sufficient plastic deformation and modifications to model boundary conditions to accurately capture the behavior of deeply cracked plates in bending. Python is the primary automation tool used in this process, including running FEACrack to create meshes, modifying material properties, iterating WARP3D boundary conditions to meet plastic deformation requirements, and converting WARP3D output into a reduced set of MATLAB-compatible data files. Bending model results from WARP3D are validated against Abaqus results for identical meshes. This report then shows the initial integration of bending models and results into the existing TASC code, laying the groundwork for a single tool for analysis of surface-cracked plates in tension or bending.
The psychometric properties of the Revised Illness Perception Questionnaire (IPQ-R) regarding Internet gaming disorder in a general population of Chinese adults
Authors: Lau Joseph T. F. , Dang Le , Cheung Ray Y. H. , Zhang Meng Xuan , Chen Juliet Honglei , Wu Anise M. S. 
Published: September 2020

AbstractBackground and aimsInternet gaming disorder (IGD) has been recognized as a mental illness. Cognitive and emotional illness representations affect coping and health outcomes. Very little is known about such perceptions related to IGD, in both general and diseased populations. This study examined the psychometric properties of the Revised Illness Perception Questionnaire (IPQ-R) for IGD in a general population that included mostly non-cases while a small proportion of the sample was IGD cases.MethodsAn anonymous cross-sectional telephone survey was conducted in a random sample of 1,501 Chinese community-dwelling adults (41.3% male; mean age = 40.42, SD = 16.85) in Macao, China.ResultsThe confirmatory factor analysis identified a modified 6-factor model (i.e., timeline cyclical, consequences, personal control, treatment control, illness coherence, and emotional representations) of 26 items that showed satisfactory model fit and internal consistency. Criterion-related validity was supported by the constructs' significant correlations with stigma (positive correlations: timeline cyclical, consequence, emotional representations; negative correlations: illness coherence). Ever-gamers, compared to never-gamers, reported higher mean scores in the subscales of personal control and illness coherence, and lower mean scores in time cyclical, consequence, and emotional representations. Among the sampled gamers, probable IGD cases were more likely than non-IGD cases to perceive IGD as cyclical and involved more negative emotions.ConclusionsThis study shows that the revised 26-item version of IPQ-R is a valid instrument for assessing illness representation regarding IGD in a general population of Chinese adults. It can be used in future research that examines factors of incidence and prevention related to IGD.
Measurement, prevalence, and psychological risk factors associated with addictive food consumption: Development of a new food addiction scale and evidence from a national largescale sample
Authors: Kircaburun Kagan , Ünübol Hüseyin , Sayar Gökben H. , Stavropoulos Vasileios , Griffiths Mark D. 
Published: September 2020

AbstractBackground and aimsTo date, a number of studies have investigated the prevalence and correlates of addictive food consumption. However, these studies have mostly relied on models that comprised a narrow range of variables in often small and heterogenous samples. The purpose of the present study was to comprehensively examine the measurement aspects, the prevalence, and the psychological correlates of addictive eating among a largescale national sample of Turkish adults.MethodParticipants (N = 24,380, 50% men, Mage = 31.79 years, age range = 18–81 years) completed a battery of tests including the Food Addiction Risk Questionnaire (FARQ), the Brief Symptom Inventory, the Toronto Alexithymia Scale, the Positive and Negative Affect Schedule, and the Experiences in Close Relationships-Revised.ResultsAccording to analyses conducted, the FARQ had a uni-dimensional factor structure. Based on Item Response Theory (IRT) calculated cut-off scores, 2.3% of the participants were at risk of addictive eating patterns, whilst criteria varied in their discriminating ability. The correlates of addictive food consumption were being male, being younger, having lower education, presenting with higher alcohol use, psychiatric symptoms, alexithymia, positive/negative affect, and anxious attachment.ConclusionThese results suggest that a minority of Turkish community are at risk for addictive food consumption and that adverse psychological states promote this problematic behavior.
Correlations between mobile phone addiction and anxiety, depression, impulsivity, and poor sleep quality among college students: A systematic review and meta-analysis
Authors: Li Ying , Li Guangxiao , Liu Li , Wu Hui 
Published: September 2020

AbstractBackground and aimsMobile phone addiction (MPA) is frequently reported to be correlated with anxiety, depression, stress, impulsivity, and sleep quality among college students. However, to date, there is no consensus on the extent to which those factors are correlated with MPA among college students. We thus performed a meta-analysis to quantitatively synthesize the previous findings.MethodsA systematic review and meta-analysis was conducted by searching PubMed, Embase, Cochrane Library, Wanfang, Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Chinese Biological Medicine (CBM) databases from inception to August 1, 2020. Pooled Pearson's correlation coefficients between MPA and anxiety, depression, impulsivity, and sleep quality were calculated by R software using random effects model.ResultsForty studies involving a total of 33, 650 college students were identified. Weak-to-moderate positive correlations were found between MPA and anxiety, depression, impulsivity and sleep quality (anxiety: summary r = 0.39, 95% CI = 0.34–0.45, P < 0.001, I2 = 84.9%; depression: summary r = 0.36, 95% CI = 0.32–0.40, P < 0.001, I2 = 84.2%; impulsivity: summary r = 0.38, 95% CI = 0.28–0.47, P < 0.001, I2 = 94.7%; sleep quality: summary r = 0.28, 95% CI = 0.22–0.33, P < 0.001, I2 = 85.6%). The pooled correlations revealed some discrepancies when stratified by some moderators. The robustness of our findings was further confirmed by sensitivity analyses.ConclusionsThe current meta-analysis provided solid evidence that MPA was positively correlated with anxiety, depression, impulsivity, and sleep quality. This indicated that college students with MPA were more likely to develop high levels of anxiety, depression, and impulsivity and suffer from poor sleep quality. More studies, especially large prospective studies, are warranted to verify our findings.
Az új típusú koronavírus okozta megbetegedés (COVID–19): összefoglaló hematológusoknak I. – virológia, molekuláris patogenezis és klinikum
Authors: Szabó Bálint Gergely , Bobek Ilona , Réti Marienn , Gopcsa László , Mathiász Dóra , Lakatos Botond , Bekő Gabriella , Pető Mónika , Sinkó János , Mikala Gábor , Kis Zoltán , Szlávik János , Reményi Péter , Vályi-Nagy István 
Published: September 2020

Absztrakt:
A COVID–19 a SARS-CoV-2 vírus által okozott, járványosan terjedő, légúti
kiindulású betegség. A kórokozó magas patogenitású, zoonotikus eredetű humán
coronavírus, mely hatékonyan terjed emberről emberre cseppfertőzéssel és közeli
kontaktussal. A medián lappangási idő 5 nap, a maximum 14 nap. A COVID–19
kardinális tünetei a láz, dyspnoe és száraz köhögés. Az esetek 80%-a enyhe
lefolyású, 5%-ban azonban intenzív terápiás ellátás és gépi lélegeztetés válik
szükségessé. A COVID–19 akár súlyos, az egész szervezetre kiterjedő
citokinvihart is kiválthat, mely gyors beavatkozás nélkül végzetes kimenetelű
lehet. Jelen összefoglaló – melyet a diagnosztikai és terápiás szempontokat
tárgyaló társközlemény követ – a betegséggel kapcsolatban 2020. május 25-ig
elérhető legfőbb nemzetközi és hazai irodalmi eredményeket ismerteti;
elsősorban, de nem kizárólag hematológus kollégák számára.
A SARS-CoV2-járvány hatása a hazai vérellátásra
Authors: Tordai Attila , Nagy Sándor , Baróti-Tóth Klára , Marton Imelda , Lázár Mária , Demeter Judit , Masszi Tamás , Matusovits Andrea 
Published: September 2020

Absztrakt:
A súlyos akut légúti szindrómát kiváltó, új típusú koronavírus, a SARS-CoV2 olyan
példátlan világjárványt okozott, amely szélsőséges terhelést jelent a még a
legfejlettebb országok egészségügyi rendszereire is és azok társadalmaira. Az
újonnan emberi kórokozóvá váló vírus ellen sem védőoltás, sem hatékony célzott
terápia nem áll rendelkezésre. A járványhelyzetre reagálva a világszerte, köztük
Magyarországon is, meghozott szigorú korlátozások a vérellátás tevékenységét
egyfelől a donációs hajlandóság és aktivitás kifejezett csökkenése, másfelől a
felhasználók igényeinek nehezebben jósolható csökkenése révén érintették. Az
OVSz országos adatai szerint a vörösvérsejt-, illetve plazmakészítmények
felhasználása mintegy 30%-os, míg a thrombocytakészítményeké mintegy 20%-os
csökkenést mutatott 2020. április hónapban az előző év azonos időszakához
képest. Ugyanebben az időszakban a mobil véradási események száma országosan
61%-kal, a véradásra megjelent donorok száma pedig 28%-kal csökkent. A korábban
járványt okozó légúti vírusokkal és a SARS-CoV2-vel is meglevő klinikai
tapasztalatok alapján nem valószínűsíthető az új koronavírus hematogén úton
történő átvitele, így a véradás előtti szűrés sem indokolt a potenciálisan
fertőzöttek kiszűrését segítő általános óvintézkedések betartása mellett. A
hematológiai betegellátásban a vérkészítmények felhasználásának csökkenése
kisebb mértékű volt, és kifejezett szóródást mutatott a vizsgált szegedi és
budapesti egyetemi központok összehasonlításában. Az új kórokozó elleni vakcina
és célzott kezelés hiányában a SARS-CoV2 elleni konvaleszcens plazmaterápia
ígéretes és racionális, azonnal hozzáférhető terápiás lehetőség. Az FDA
kivételesen gyorsan meghozott bátorító állásfoglalása és irányelve hatására több
párhuzamos, nagyobb esetszámú és a korszerű klinikai kutatási szempontokat is
figyelembe vevő, a SARS-CoV2 elleni konvaleszcens plazmaterápiára irányuló
klinikai vizsgálat indult az USA-ban és más nyugati országokban, köztük
Magyarországon is a vérellátó szolgálatok aktív részvételével.