bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads
Authors: Vlachou Marilena , Siamidi Angeliki , Goula Efstratia , Georgas Panagiotis , Pippa Natassa , Karalis Vangelis , Sentoukas Theodore , Pispas Stergios 
Published: May 2020

Abstract
A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance.
Phylogenetic Analysis of HA and NA Genes of Swine Influenza Viruses in Serbia in 2016-2018
Authors: Maksimović Zorić Jelena , Milićević Vesna , Stevančević Ognjen , Chiapponi Chiara , Potkonjak Aleksandar , Stojanac Nenad , Kureljušić Branislav , Veljović Ljubiša , Radosavljević Vladimir , Savić Božidar 
Published: May 2020

AbstractPigs are very important for the epidemiology of influenza A viruses, being commonly infected with the lineages of most adapted H1N1, H3N2, H1N2 swine subtypes. Epidemiological complexity of swine influenza is increasing by a periodic spillover of human or avian viruses in the pig population when genetic shifts can occur. The objectives of this research were to determine the presence of the influenza A virus in nasal and tracheobronchial swabs and lung tissue samples of ill and dead pigs on commercial farms, to determine circulating subtypes and characterize them through the phylogenetic analysis of hemagglutinin (HA) and neuraminidase (NA) genes. A total of 255 samples collected from 13 farms were analyzed by means of real-time RTPCR. The genome of influenza A virus was detected in 24 samples, which represented a 61.5% prevalence at the farms level (influenza A virus was confirmed in 8 out of 13 farms included in this study). Based on HA and NA gene sequences of 8 viruses, the circulation of H1N1 and H3N2 subtypes of influenza A viruses were determined. In addition, one farm exhibited a time separated circulation of H1N1 and H3N2 virus subtypes. Using Influenza Research Database, our viruses of the H1 subtype were classified into 1C.2.1 and 1A.3.3.2. clade. Based on the nucleotide sequences of HA genes, three viruses of the H1N1 subtype belong to the H1N1pdm09 lineage, and the other four to Eurasian “avian-like” H1avN1 lineage; while based on NA genes sequences, these seven viruses belong to Eurasian “avian-like” H1avN1 lineage. Both HA and NA genes of the virus of the H3N2 subtype belonged to the A/swine/ Gent/1/1984-like H3N2 lineage.
Dietary Supplementation of a Yeast-Whey Preparation for Weaned Piglets
Authors: Szuba-Trznadel Anna , Hikawczuk Tomasz , Korzeniowska Małgorzata , Fuchs Bogusław 
Published: May 2020

Abstract
Weaning is a stressful period for the piglets and the sow. Stress during weaning is related to the change of diet which can affect the physiology of the gastrointestinal tract, as well as the microbial and immunological status of the animals. In the experiment a yeast-whey preparation was used to decrease the transient growth depression related to reduction of feed intake by the piglets. The piglets were assigned to three treatments. In the control group (I) the animals obtained standard feed mixture used routinely at the farm. In the case of piglets from II and III treatment, the yeast-whey preparation was added in the quantity of 4 and 7%, respectively.
Application of 7% yeast-whey preparation to the diet significantly increased the body weight of piglets (p<0.05) and in consequence the average daily body weight gain (p<0.01) in comparison with the control group of animals. Additionally, piglets which were fed the yeast-whey preparation diet had a higher feed intake (p<0.05) and better feed conversion ratio (p<0.05) than those fed a diet without the addition of this preparation. No significant differences were stated for most biological parameters (p>0.05), except for the blood urea level, which was significantly lower (p<0.05) in the treatments where the yeast-whey preparation was used. These results indicated that yeast-whey preparation efficiently suppressed post-weaning diarrhea and improved the performance of the animals.
Research of 316L Metallic Powder for Use in SLM 3D Printing
Authors: Hajnys J. , Pagac M. , Mesicek J. , Petru J. , Spalek F. 
Published: May 2020

Abstract
3D metal printing is an increasingly popular production of steel parts. The most widespread and most accurate method is SLM (Selective Laser Melting), which uses metallic powder as the input material. The article is dedicated to researching the supplied powder from Renishaw. The powder is made by gas atomization and 3 phases of powder (virgin, sift and waste) that are present in the SLM process are examined. Powder morphology by SEM electron microscopy is investigated and the porosity of the powder is measured by optical method. Next, the powder grain size fraction is examined. In conclusion, there are recommendations and other directions of possible research. The main quantitative result from research is that, in general, small particles are reduced in the sift powder and the number of larger particles is increased, but the powder is still usable for further use.
Physiological Response to Non-Traditional High-Intensity Interval Training
Authors: Schlegel Petr , Hiblbauer Jan , Agricola Adrián 
Published: May 2020

Summary
High intensity interval training (HIIT) is an exercise program not only for professional athletes, but also for the general population. Usually, one-dimensional modalities such as running or a cycling simulator are used. There also exist protocols that use the HIIT principles but apply full-body exercises (HWT). The purpose of the study was to verify the response to unconventional loads based on HIIT and HWT protocols using the near infrared spectroscopy (NIRS) and spiroergometry: wall ball (WB); SKI ergometer, toes to bar (TTB) and assault air bike (AB) in a selected proband. Working interval was 60 s resp. 30 s, the rest between sites was progressively reduced from 60 s to 30 s. The proband completed a total of 3 laps. The results showed that the load applied had been similar to that of HWT or HIIT, where the effect on cardiorespiratory and metabolic functions was confirmed. Acute changes in the observed parameters of SmO2 in m. vastus lateralis indicate a possible effect on the development of strength capabilities. It has also been confirmed that the application of variable types of load can be applied simultaneously with the adjustment of rest time and thus using conditions that can reflect current options (material, environment, time) and specific goals. The measured values of muscle tissue oxidation, carbon dioxide output, heart rate confirm that a similar type of load can be a suitable means of affecting cardiovascular and metabolic functions.
Factors Involved in the Pathogenesis of Acne and Its Psycho-Social Impact
Authors: Voidăzan Septimiu , Toth Reka , Varo Teodora 
Published: May 2020

Abstract
With acne as one of the most common and frequent conditions of young adult patients, we looked for significant associations, associated conditions with influence on the skin condition with the idea of outlining a different approach of the acne patient. With a multifactorial, multi-disciplinary etiopathogeny, the purpose of this study was to highlight the factors involved in the pathogenesis of this condition and to identify those that should be taken into account when prescribing the treatment.
Cardiac Autonomic Neuropathy in Diabetes Mellitus Patients – Are We Aware of the Consequences?
Authors: Motataianu Anca , Barcutean Laura Iulia , Maier Smaranda , Balasa Adrian , Stoian Adina 
Published: May 2020

Abstract
Cardiovascular autonomic neuropathy is the most frequent clinical form of autonomous diabetic neuropathy and appears secondary to cardiac autonomous fibre involvement, actively involved in cardiac rhythm impairment. Type 2 diabetes mellitus patients can present cardiac autonomic neuropathy early in the disease. Autonomous nerve function in DM patients should be assessed as early as the diagnosis is set in order to establish the optimal therapeutic strategy. The most frequent cardio-vagal test used is heart rate variability. An abnormal heart rate variability in the presence of orthostatic arterial hypotension indicates a severe cardiac autonomic neuropathy diagnosis. The development of cardiac autonomic neuropathy is subjected to glycaemic control, duration of the disease and associated risk factors. The glycaemic control is extremely important, especially early in the disease. Therefore, a poor glycaemic control carries unfavourable long-term effects, despite an ulterior optimal control, a phenomenon named “hyperglycaemic memory”. In type 2 diabetes mellitus patients, the association of cardiac autonomic neuropathy with intensive glycaemic control increases the mortality rate, due to the fact, that, secondary to autonomous impairment, the patients do not present the typical symptoms associated with hypoglycaemia. Stratifying the cardiac autonomic neuropathy aids the clinician in assessing the morbidity and mortality risk of diabetes mellitus patients, because it is an independent risk factor for mortality, associated with silent myocardial infarctions and the risk of sudden death.
The relative bioavailability of two formulations containing 10 mg Dapagliflozin assessed under fasting conditions in a randomized crossover study in healthy Caucasian subjects
Authors: Oroian Monica , Pop Diana Ioana , Gheldiu Ana-Maria , Bhardwaj Sandeep , Marcovici Adriana , Khuroo Arshad , Vlase Laurian 
Published: May 2020

Abstract

Objective: The aim of the present study was to evaluate the relative bioavailability of two formulations containing 10 mg dapagliflozin in healthy Caucasian subjects under fasting conditions.

Materials and Methods: Forty-eight healthy Caucasian subjects were enrolled in a single-dose, crossover, balanced, open label, randomized clinical trial, with two treatment, two periods and two sequences. The wash-out period was of 7 days and thirty-eight subjects completed both study periods. Each subject received a single dose of 10 mg dapagliflozin as the reference product Farxiga® (AstraZeneca Pharmaceuticals LP, USA) and the test product developed by Sun Pharmaceutical Industries, India. Dapagliflozin plasma levels were determined from blood samples collected in both study periods before and after dosing until 48 hours by using a validated LC-MS/MS method. For pharmacokinetic analysis of data, the non-compartmental method was used (Phoenix® WinNonlin 6.3). The statistical analysis was performed by SAS software 9.1.3 for the logarithmically transformed values of maximum plasma concentration and area under the curve.

Results: The 90% confidence intervals for the evaluated pharmacokinetic parameters were found to be in the accepted interval for bioequivalence (80.00-125.00%).

Conclusion: The 10 mg dapagliflozin immediate release tablet newly developed by Sun Pharmaceutical Industries, India, is bioequivalent with the reference product Farxiga® under fasted state of the subjects.
Fractional Calculus of the Extended Hypergeometric Function
Authors: Şahin Recep , Yağcı Oğuz 
Published: May 2020

Abstract
Here, our aim is to demonstrate some formulae of generalization of the extended hypergeometric function by applying fractional derivative operators. Furthermore, by applying certain integral transforms on the resulting formulas and develop a new futher generalized form of the fractional kinetic equation involving the generalized Gauss hypergeometric function. Also, we obtain generating functions for generalization of extended hypergeometric function..
Optimal position of piezoelectric actuators for active vibration reduction of beams
Authors: Kouider Bendine , Polat Alper 
Published: May 2020

Abstract
This paper investigates the optimal placement of piezoelectric actuators for the active vibration attenuation of beams. The governing equation of the beam is achieved by coupled first order shear deformation theory with two node element. The velocity feedback controller is designed and used to calculate the feedback gain and then apply to the beam. In order to search for the optimal placement of the piezoelectric actuators, a new optimization criterion is considered based on the use of genetic algorithm to reduce the displacement output of the beam. The proposed optimization technique has been tested for two boundary conditions configurations; clamped -free and clamped-clamped beam. Numerical examples have been provided to analyze the effectiveness of the proposed technic.
A Numerical Scheme For Semilinear Singularly Perturbed Reaction-Diffusion Problems
Authors: Yamac Kerem , Erdogan Fevzi 
Published: May 2020

Abstract
In this study we investigated the singularly perturbed boundary value problems for semilinear reaction-difussion equations. We have introduced a basic and computational approach scheme based on Numerov’s type on uniform mesh. We indicated that the method is uniformly convergence, according to the discrete maximum norm, independently of the parameter of ɛ. The proposed method was supported by numerical example.
A finite difference method on layer-adapted mesh for singularly perturbed delay differential equations
Authors: Erdogan Fevzi , Sakar Mehmet Giyas , Saldır Onur 
Published: May 2020

Abstract
The purpose of this paper is to present a uniform finite difference method for numerical solution of a initial value problem for semilinear second order singularly perturbed delay differential equation. A numerical method is constructed for this problem which involves appropriate piecewise-uniform Shishkin mesh on each time subinterval. The method is shown to uniformly convergent with respect to the perturbation parameter. A numerical experiment illustrate in practice the result of convergence proved theoretically.
New Analytical Solutions of Conformable Time Fractional Bad and Good Modified Boussinesq Equations
Authors: Durur Hülya , Tasbozan Orkun , Kurt Ali 
Published: May 2020

Abstract
The main purpose of this article is to obtain the new solutions of fractional bad and good modified Boussinesq equations with the aid of auxiliary equation method, which can be considered as a model of shallow water waves. By using the conformable wave transform and chain rule, nonlinear fractional partial differential equations are converted into nonlinear ordinary differential equations. This is an important impact because both Caputo definition and Riemann–Liouville definition do not satisfy the chain rule. By using conformable fractional derivatives, reliable solutions can be achieved for conformable fractional partial differential equations.
Evaluation of Investment Opportunities With Interval-Valued Fuzzy Topsis Method
Authors: Lanbaran Naiyer Mohammadi , Celik Ercan , Yiğider Muhammed 
Published: May 2020

Abstract
The purpose of this study is extended the TOPSIS method based on interval-valued fuzzy set in decision analysis. After the introduction of TOPSIS method by Hwang and Yoon in 1981, this method has been extensively used in decision-making, rankings also in optimal choice. Due to this fact that uncertainty in decision-making and linguistic variables has been caused to develop some new approaches based on fuzzy-logic theory. Indeed, it is difficult to achieve the numerical measures of the relative importance of attributes and the effects of alternatives on the attributes in some cases. In this paper to reduce the estimation error due to any uncertainty, a method has been developed based on interval-valued fuzzy set. In the suggested TOPSIS method, we use Shannon entropy for weighting the criteria and apply the Euclid distance to calculate the separation measures of each alternative from the positive and negative ideal solutions to determine the relative closeness coefficients. According to the values of the closeness coefficients, the alternatives can be ranked and the most desirable one(s) can be selected in the decision-making process.
Genome-Wide Association Study Using Fix-Length Haplotypes and Network Analysis Revealed New Candidate Genes for Nematode Resistance and Body Weight in Blackface Lambs
Authors: Farahani Amir Hossein Khaltabadi , Mohammadi Hossein , Moradi Mohammad Hossein 
Published: May 2020

Abstract
The objectives of this study were to identify genomic regions by Bayesian methods (BayesA, BayesB, or BayesN) that fit fixed-length haplotypes or SNPs using GenSel. Covariates for haplo-type alleles of five lengths (125, 250, 500 kb, 1 or 2 Mb) were generated, and rare haplotypes were removed at three thresholds (1, 5, or 10%). Subsequently, we performed gene network analyses to investigate the biological processes shared by genes that were identified for the same across traits. Genotypes at 41,034 SNPs that were common on OvineSNP50 panel were phased for 751 Scottish Blackface (SBF) lambs. This is the first study to quantify the proportion of genetic variance using haplotypes across the whole genome in an SBF population. The genetic variance explained of haplotype-based GWAS was higher than that of SNP-based GWAS in across traits studied. In this population, fitting 500kb haplotypes with a 1% frequency threshold resulted in the highest proportion of genetic variance explained for nematode resistance and fitting 2Mb haplotypes with a 10% frequency threshold improved genetic variance explained for body weight comparable to fitting SNPs by BayesB. Candidate genes, including CXCR4, STAT4, CCL1, CCL2, CCL3, CCL5, CCL8, CCL16, CCL18, CARMIL2, and HSPA14 were identified for nematode resistance and ADH5, PPP3CA, and FABP4 for body weight traits. Network analysis provided annotation results linking to all identified candidate genes. This study supported previous results from GWAS of nematode resistance and body weight and revealed additional regions in the ovine genome associated with these economically important traits. These results suggest that network analysis can provide new information regarding biological mechanisms and genes leading to complex phenotypes, like nematode resistance and body weight of lamb.
The insecticidal activity of the endophytic fungus Isaria fumosorosea Wize isolated from the leaves of the Ricinus communis L. against Locusta migratoria L. and Acanthoscelides obtectus Say
Authors: Laib Djamel Eddine , Benzara Abdelmadjid , Akkal Salah 
Published: May 2020

Abstract
This study was conducted to evaluate the insecticidal activity of the endophytic fungus Isaria fumosorosea Wize isolated from Ricinus communis L. against Locusta migratoria L. and Acanthoscelides obtectus Say. To evaluate the insecticidal activity, a mixture of fungal extract and spore suspensions (1x107, 1x106 and 1x105 spores/ml of dissolved extract) were applied against the insects. It was found that I. fumosorosea had a good insecticidal activity, positively proportional to concentration and time after exposure (24, 48, 72 hours). A maximum mortality rate of 80% for A. obtectus and 70% for L. migratoria at 1x107 spores/ml of dissolved extract was recorded. Preliminary phytochemical analyses of the fungal extract revealed the presence of alkaloids, flavonoids and phenols. Additionally, a fungal development on the insects bodies has also been noticed; that is undoubtedly explained the recorded insecticidal activity.
The influence of extraction method on antioxidant potential of Tilia argentea flowers and bracts
Authors: Ayaz Seyhan Serap , Yilmaz Zümrüt , Çikla Yilmaz Deniz 
Published: May 2020

Abstract
The objective of this work was to compare the extraction of phenolic compounds from Tilia argentea flowers and bracts by using conventional (solvent extraction) and novel (ultrasound assisted) extraction methods. Ethanol (70 %) extracts were analyzed for their antioxidant activities. Total phenolic content was determined using Folin-Ciocalteu method and the antioxidant potential was determined by DPPH radical scavenging and Ferric Reducing Antioxidant Power (FRAP) assays. To determine the effect of ultrasound treatment on the extraction, same extraction parameters were applied in both methods. The results showed that extracts obtained by ultrasound assisted extraction have higher total phenolic content and antioxidant activity.
Maximal functions for Weinstein operator
Authors: Abdelkefi Chokri 
Published: May 2020

Abstract
In the present paper, we study in the harmonic analysis associated to the Weinstein operator, the boundedness on L

p
of the uncentered maximal function. First, we establish estimates for the Weinstein translation of characteristic function of a closed ball with radius ɛ centered at 0 on the upper half space ℝd–1× ]0, +∞ [. Second, we prove weak-type L
1-estimates for the uncentered maximal function associated with the Weinstein operator and we obtain the L

p
-boundedness of this operator for 1 < p ≤ + ∞. As application, we define a large class of operators such that each operator of this class satisfies these L

p
-inequalities. In particular, the maximal operator associated respectively with the Weinstein heat semigroup and the Weinstein-Poisson semigroup belong to this class.
On dilation and commuting liftings of n-tuples of commuting Hilbert space contractions
Authors: Burdak Zbigniew , Grygierzec Wiesław 
Published: May 2020

Abstract
The n-tuples of commuting Hilbert space contractions are considered. We give a model of a commuting lifting of one contraction and investigate conditions under which a commuting lifting theorem holds for an n-tuple. A series of such liftings leads to an isometric dilation of the n-tuple. The method is tested on some class of triples motivated by Parrotts example. It provides also a new proof of the fact that a positive definite n-tuple has an isometric dilation.
Approximate multi-Jensen-cubic mappings and a fixed point theorem
Authors: Ramzanpour Elahe , Bodaghi Abasalt 
Published: May 2020

Abstract
In this paper, we introduce multi-Jensen-cubic mappings and unify the system of functional equations defining the multi-Jensen-cubic mapping to a single equation. Applying a fixed point theorem, we establish the generalized Hyers-Ulam stability of multi-Jensen-cubic mappings. As a known outcome, we show that every approximate multi-Jensen-cubic mapping can be multi-Jensen-cubic.