bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke in COVID-19: a single-centre initial experience in a hotspot of the pandemic
Authors: Bach Ivo , Surathi Pratibha , Montealegre Nora , Abu-Hadid Osama , Rubenstein Sara , Redko Sviatoslav , Gupta Siddharth , Hillen Machteld , Patel Pratit , Khandelwal Priyank , Kamel Adham 
Published: September 2020

BackgroundCOVID-19, caused by SARS-CoV-2, is a global pandemic that has been an immense burden on healthcare systems all over the world. These patients may be at higher risk for acute ischaemic stroke (AIS). We present our experience with AIS in patients with COVID-19.MethodsWe reviewed all patients admitted to our hospital during a 6-week period with a positive nasopharyngeal swab test for SARS-CoV-2. Among these patients, we identified AIS. We reviewed the demographics, clinical, laboratory, imaging characteristics, treatments received and outcomes of AIS in patients with COVID-19.ResultsWe identified 683 patients admitted with COVID-19 during the study period, of which 20 patients had AIS. Large-vessel occlusion (LVO) was noted in 11 patients (55%). Intravenous alteplase was administered in four patients (20%) and mechanical thrombectomy was performed in five patients (25%). Respiratory symptoms preceded the onset of AIS in most of the patients (70%) by 1 to 21 days. Mortality in patients with AIS was 50% compared with 26% of all COVID-19 admissions. Most of these patients died due to non-neurological causes (70%). Three patients with AIS had clinical and imaging findings consistent with COVID-19, but were negative for multiple nasopharyngeal swab tests.InterpretationLVO was more common in patients with AIS and COVID-19. They had more severe disease and higher mortality rates. Most of the patients had respiratory symptoms preceding AIS by days to weeks. This could explain certain patients with clinical picture of COVID-19 but negative nasopharyngeal swab tests.
Das ist der HAMMER: consistent new physics interpretations of semileptonic decays
Authors: Bernlochner Florian U. , Duell Stephan , Ligeti Zoltan , Papucci Michele , Robinson Dean J. 
Published: September 2020

AbstractPrecise measurements of $$b\rightarrow c\tau \bar{\nu }$$

b
→
c
τ

ν

¯

decays require large resource-intensive Monte Carlo (MC) samples, which incorporate detailed simulations of detector responses and physics backgrounds. Extracted parameters may be highly sensitive to the underlying theoretical models used in the MC generation. Because new physics (NP) can alter decay distributions and acceptances, the standard practice of fitting NP Wilson coefficients to SM-based measurements of the $$R(D^{(*)})$$

R
(

D

(

∗
)

)

ratios can be biased. The newly developed software tool enables efficient reweighting of MC samples to arbitrary NP scenarios or to any hadronic matrix elements. We demonstrate how allows avoidance of biases through self-consistent fits directly to the NP Wilson coefficients. We also present example analyses that demonstrate the sizeable biases that can otherwise occur from naive NP interpretations of SM-based measurements. The library is presently interfaced with several existing experimental analysis frameworks and we provide an overview of its structure.
Predictors of Bleeding in the Perioperative Anticoagulant Use for Surgery Evaluation Study
Authors: Tafur Alfonso J. , Clark Nathan P. , Spyropoulos Alex C. , Li Na , Kaplovitch Eric , MacDougall Kira , Schulman Sam , Caprini Joseph A. , Douketis James 
Published: September 2020

Background
In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study, a simple, standardized, perioperative interruption strategy was provided for patients with nonvalvular atrial fibrillation taking direct oral anticoagulants (DOACs). Our objective was to define the factors associated with perioperative bleeding.

Methods and Results

We analyzed bleeding as the composite of major and clinically relevant nonmajor bleeding. Putative predictors of bleeding, and preoperative DOAC level were prospectively collected during recruitment. We used stratified logistic regression models for analysis. All statistical analyses were performed in R version 3.6.0. There were 3007 patients requiring perioperative DOAC interruption. More than one third of the included patients underwent a high bleeding risk procedure. The 30‐day rates of major and clinically relevant nonmajor bleeding were 3.02% in apixaban (n=1257), 2.84% in dabigatran (n=668), and 4.16% for rivaroxaban (n=1082). Multivariate analysis stratified by region found more bleeding for hypertension (odds ratio [OR], 1.79; 95% CI 1.07‐2.99;
P
=0.027), and prior bleeding (OR, 1.71; 95% CI, 1.08‐2.71;
P
=0.021). Surgical bleed risk classification (high‐ versus low‐risk) as a predictor of bleeding was only significant in the univariate analysis. The prediction model for major and clinically relevant nonmajor bleeding had an area under the curve of 0.71, and the preoperative DOAC level did not improve the area under the curve of the model.

Conclusions
In patients treated with DOACs who required an elective surgery/procedure and were managed with standardized DOAC interruption and resumption, there we did not find reversible risk factors for bleeding, suggesting that adjustment of the PAUSE management protocol to mitigate against bleeding is not needed.
‘Blackened face’: Emotional Community and the Hindu Nationalist Interpretation of History
Authors: Vanina Eugenia 
Published: September 2020

Abstract
When in 1664 the Mughal emperor Aurangzeb appointed a Rajput general, Mirza Raja Jai Singh Kachwaha, as commander-in-chief of a punitive army sent against the Maratha warlord Shivaji, contemporary authors recorded it dispassionately as a trivial occurrence. Emotional perception of the event had changed drastically by the early twentieth century, when the proponents of Hindu nationalism began to view Jai Singh with disgust and anger as a ‘traitor to the Hindu nation’. Analysis of ‘Letter of Maharaja Shivaji to Mirza Raja Jai Singh’ (‘Mahārāj Śivājī kā patr Mirzā Rājā Jai Siṅgh ke nām’), by the Hindi classic poet Suryakant Tripathi Nirala, discloses the communicative means employed by the author to ‘reboot’ the emotional attitudes of his readers and to rope them into the emotional community of Hindu nationalists.
Cyclone Wind Retrieval Based on X-Band SAR-Derived Wave Parameter Estimation
Authors: Shao Weizeng , Hu Yuyi , Nunziata Ferdinando , Corcione Valeria , Migliaccio Maurizio , Li Xiaoming 
Published: September 2020

AbstractIn this study, a method for retrieving wind speed from synthetic aperture radar (SAR) imagery collected under extreme weather conditions is proposed. The rationale for this approach relies on the fact that, although copolarized channels exhibit saturation for wind speed >~20 m s−1, the wave growth can be successfully exploited to gather information on wind speed under extreme weather conditions. Hence, in this study, the intrinsic relationship among the wind-wave triplets [wind speed at 10 m above the sea surface, significant wave height (SWH), and peak wave period] is exploited in order to retrieve wind speeds under tropical cyclone conditions. Experiments, undertaken on actual X-bandTerraSAR-X(TS-X) SAR images of tropical cyclones (Typhoon Megi, Hurricane Sandy, and Hurricane Miriam) and using collocated WAVEWATCH-III (WW3) simulations, revealed the robustness of the proposed approach, which resulted in a root-mean-square error (RMSE) of 2.54 m s−1when comparing the retrieved wind speeds with the values from products delivered by the National Oceanic and Atmospheric Administration (NOAA) Hurricane Research Division (HRD). However, the applicability of the algorithm herein will be further confirmed at very strong storms.
Does Level of Blood Alcohol Content Affect Clinical Outcomes After Trauma in Older Adult Patients?
Authors: Bryant Mary K. , Reynolds Katherine , Brittain Connor , Patel Zachery , Reid Trista D.S. , Maine Rebecca G. , Udekwu Pascal 
Published: September 2020

Introduction Preinjury alcohol use and older age have independently been associated with poor outcomes. This study examined whether higher levels of blood alcohol concentration (BAC) correlated with an increased likelihood of poor outcomes in older trauma patients. Methods This was a retrospective cohort study of injured patients ≥65 years with BAC testing presenting to a Level 1 trauma center between 2015 and 2018. Patients were stratified by BAC at 4 thresholds of intoxication: BAC ≧10 mg/dL, BAC ≧80 mg/dL, BAC ≧150 mg/dL, and BAC ≧200 mg/dL. Propensity score matching using inverse probability of treatment weighting was used to estimate outcomes. Logistic and Poisson regression models were performed for each threshold of the BAC level with the matched cohort to assess clinical outcomes. Results Of all older patients (n = 3112), 32.5% (n = 1012) had BAC testing. In the matched cohort of 883 patients (76.7 ± 8.2 years; 48.1% female), 111 (12.5%) had BAC ≧10 mg/dL, 83 (74.8%) had BAC ≧80 mg/dL, 60 (54.1%) had BAC ≧150 mg/dL, and 37 (33.3%) had BAC ≧200 mg/dL. Falls (60.5%) and motor vehicle crashes (28.9%) were the most common mechanisms of injury. Median (IQR) of Injury Severity Score (ISS) was 5 (1-10). The risk of severe injury (ISS ≧15) was similar between alcohol-positive and alcohol-negative patients (9.9% vs 15.0%, P = .151). BAC ≧10 g/dL was not associated with length of stay, intensive care unit admission, or in-hospital complication, nor was any of the other 3 analyzed BAC thresholds. Conclusion Overall, any detectable BAC along and increasing thresholds of BAC was not associated with poor in-hospital outcomes of older patients after trauma. Alcohol screening was low in this population, and intoxication may bias injury assessment, leading to mistriage of older trauma patients.
Delivery of Time-Bound Public Services to Citizens: Indian Experience
Authors: Pareek Urvashi , Sole Nagendra Ambedkar 
Published: September 2020

The delivery of public services to the citizens is the most critical function of the government, among the other functions being development and regulation. The three essential pillars of public service delivery are timelines, quality and grievance redressal. The concept of public service delivery emerged in the 1990s, with New Public Management and Citizen Charter’s evolution in the UK. With the shift in the role of the state from provider to facilitator and regulator of public services, the focus is to ensure transparency, accountability and citizen centricity in administration and maintain citizen’s satisfaction and trust in the government. This article highlights the concept of public service delivery, and time-bound delivery practices, adopted internationally and nationally. The article concludes that India needs to look beyond Information and Communications Technology and capitalise on other options as listed in suggestions.
Expression of Notch–Hif-1α signaling pathway in liver regeneration of rats
Authors: Li Yanshan , Xu Yunxiuxiu , Wang Ruomei , Li Wenxin , He Wenguang , Luo Xinxi , Ye Yibiao 
Published: September 2020

Objective To investigate whether the Notch–Hif-1α signaling pathway is involved in liver regeneration. Methods Rats were divided into two groups and treated with daily intraperitoneal injections of saline (control) or the gamma-secretase inhibitor, Fli-06, for 2 days. Two-thirds of the rat livers were resected and rats were later euthanized at specific time points post-resection to analyze the remnant livers. Each group's liver/body weight ratio was calculated, and immunostaining and western blotting were used to determine the cell proliferation marker, PCNA and Ki-67 expression. Real-time PCR and western blotting were used to compare the mRNA expression of Notch homolog-1 ( Notch1), hairy and enhancer of split-1 ( Hes1), and vascular endothelial growth factor ( Vegf), and the protein expression of NICD and HIF-1α, respectively. Results The liver/body weight ratios and number of Ki-67- and PCNA-positive cells were significantly lower in the experimental group than the control group, indicating lower levels of liver regeneration following the disruption of Notch signaling by Fli-06. The Hes1 and Vegf mRNA levels and NICD and HIF-1α protein expression levels were all down-regulated by Fli-06 treatment. Conclusion Notch–Hif-α signaling pathway activation plays an important role in liver regeneration, where it may contribute toward liver cell proliferation.
Physical performance and activity among older adults visiting primary healthcare centres in Riyadh
Authors: Bindawas Saad M. , Vennu Vishal , Alqarni Ayidh M. , Abdulrahman Tariq A. 
Published: September 2020

Objective To assess physical performance (PP) and physical activity (PA) among older adults visiting primary healthcare centres (PHCCs) in Riyadh. Methods In this cross-sectional study, men and women (n = 74) aged ≥60 years were recruited from five PHCCs across Riyadh, Saudi Arabia, between 19 February and 6 August 2017. The Timed Up & Go test was used to assess PP. Self-reported PA was assessed using the Physical Activity Scale for the Elderly. Means and standard deviations were used to describe PP and PA scores across genders. A two-tailed independent samples t-test was used to estimate mean differences (MD) and 95% confidence intervals (CI) between genders. Results Men scored significantly lower than women on PP (MD: 2.11, 95% CI: 0.59 to 3.64) and PA (MD: −46.1, 95% CI: −80.96 to −11.25). Significant gender differences were observed for leisure time activities (MD: 17.35, 95% CI: 3.29 to 31.40), light household activities (MD: –10.86, 95% CI: –16.19 to –5.53) and heavy household activities (MD: –6.48, 95% CI: –11.73 to –1.23). Conclusions Men show significantly lower PP and PA than women. There are gender differences in leisure time activities and in light and heavy household activities.
Relationship between aortic valve stenosis and the hemodynamic pattern in the renal circulation, and restoration of the flow wave profile after correction of the valvular defect
Authors: Bardelli Moreno , Cavressi Monica , Furlanis Giulia , Pinamonti Bruno , Leone Mariafontana , Albani Stefano , Korcova Renata , Fabris Bruno , Sinagra Gianfranco 
Published: September 2020

Objective The index of maximal systolic acceleration ([AImax]: maximal systolic acceleration of the Doppler waveform divided by peak systolic velocity) shows diagnostic accuracy in screening of renal artery stenosis. This study aimed to determine whether an upstream factor of resistance, such as aortic valve stenosis (AVS), can affect Doppler parameters detected in the peripheral arteries. Methods In this prospective study, we measured the AImax in non-stenotic renal interlobar arteries of 62 patients with AVS. Patients were divided into three groups on the basis of severity of valvulopathy as follows: mild-to-moderate AVS (M-AVS; n = 24), intermediate AVS (I-AVS; n = 15), and severe AVS (S-AVS; n = 23) based on Nishimura’s criteria. Results The AImax in the renal parenchymal arteries was significantly lower in the S-AVS group (8.9 ± 3.6 s−1) than in the M-AVS (15.3 ± 3.8 s−1) and I-AVS groups (16.7 ± 5.2 s−1). The AImax was positively correlated with the aortic valve area and inversely correlated with the tranvalvular aortic pressure gradient. After aortic valve replacement, the AImax significantly increased from 10.7 ± 4.0 s−1 at baseline to 19.3 ± 4.4 s−1. Conclusions Proximal resistance can lead to diagnostic bias of Doppler parameters that are applied in the diagnosis of peripheral vasculopathies, particularly in renal artery stenosis.
The Incidence of Kaplan Fiber Injury Associated With Acute Anterior Cruciate Ligament Tear Based on Magnetic Resonance Imaging
Authors: Marom Niv , Greditzer Harry G. , Roux Michael , Ling Daphne , Boyle Caroline , Pearle Andrew D. , Marx Robert G. 
Published: September 2020

Background: Kaplan fibers are distinct deep layers of the distal iliotibial band (ITB) that anchor the ITB to the distal femur and have a role in rotational stability of the knee. However, the incidence of Kaplan fiber injury in the setting of acute anterior cruciate ligament (ACL) tear is unknown. Purpose: To determine the reliability of identifying and evaluating Kaplan fibers on magnetic resonance imaging (MRI) examinations based on previously reported characteristics and to report on the incidence of combined ACL and Kaplan fiber injuries based on MRI examinations. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Patients with an acute primary ACL tear who obtained a postinjury MRI scan at our institution and were treated with ACL reconstruction between January 1, 2007, and May 31, 2012, were identified from an institutional registry. Each patient’s postinjury MRI scan was reviewed by 2 musculoskeletal radiologists, who identified Kaplan fibers and graded them as intact, injured, or not visualized. Intrarater reliability was measured using the intraclass correlation coefficient (ICC), and interrater reliability was measured using the kappa statistic. Results: A total of 72 patients were identified. For the proximal Kaplan fibers, 50% versus 58% were identified as injured, 32% versus 29% were identified as intact, and 18% versus 13% were not visualized by radiologist 1 and 2, respectively. For the distal Kaplan fibers, 46% versus 60% were identified as injured, 43% versus 28% were identified as intact, and 11% versus 12% were not visualized by radiologist 1 and 2, respectively. The ICC intrarater reliability measurements were 0.89 (95% CI, 0.83-0.93) for proximal Kaplan fibers and 0.66 (95% CI, 0.51-0.78) for distal Kaplan fibers. The interrater reliability measurements for both radiologists showed substantial agreement (kappa = 0.7) for proximal Kaplan fibers and moderate agreement (kappa = 0.51) for distal Kaplan fibers. Conclusion: Kaplan fibers were visualized on MRI studies in the majority of cases, with substantial reliability for the proximal fibers and moderate reliability for the distal fibers. There was an associated injury to either the proximal or distal or both Kaplan fibers in the majority of acute primary ACL tears.
The Association of ICH Exclusion Criteria With Mortality and Disability Rates in ICH Patients Receiving 4F-PCC for Anticoagulation Reversal
Authors: Zaeem Maryam , Porter Blake A. , Delibert Samantha , Jones Courtney M. C. , Acquisto Nicole M. 
Published: September 2020

Background: Intracranial hemorrhage (ICH) exclusion criteria in the landmark four-factor prothrombin complex concentrate (4F-PCC) trial have not been incorporated into clinical practice and incremental predictive ability is unknown. Objectives: Evaluate the association of meeting at least 1 ICH exclusion criterion with the composite end point in-hospital mortality and modified Rankin Scale [mRS] score 5 or 6. Determine the number and combination of criteria associated with poor outcomes. Methods: Retrospective review of adult ICH patients who received 4F-PCC for anticoagulant reversal. Patient demographics, ICH exclusion criteria, in-hospital mortality, disability, and disposition were collected. χ2 Analysis and logistic regression were used to assess differences between patients with and without ICH exclusion criteria. Results: Data from 167 patients were analyzed: 103 (61.7%) met at least 1 ICH exclusion criterion. The composite end point occurred more in those with at least 1 ICH exclusion criterion (74.8% vs 39%; P < 0.0001). Presence of 2 or more ICH exclusion criteria was associated with higher odds of the composite end point, higher mRS score, and long-term care facility disposition ( P < 0.0001). Glasgow Coma Scale score <7 and at least 1 other ICH exclusion criterion had negative effects on composite end point and mortality: 95% to 100% and 85% to 100%, respectively. Conclusion and Relevance: Patients meeting at least 1 ICH exclusion criterion had greater death/disability compared with those who did not. More ICH exclusion criteria were associated with higher rates of death, disability, and worse disposition. These data may aid in developing optimal 4F-PCC use criteria.
Being a social worker in the unrecognized villages in Israel
Authors: Alhuzail Nuzha Allassad , Ibrahim Mahajne 
Published: September 2020

Summary This qualitative study presents the experiences of social workers whose clients are the inhabitants of unrecognized Bedouin Arab villages in Israel. Bedouin Arabs are an indigenous people, a minority population residing throughout Israel. Half of those in the south of the country inhabit villages that are not recognized by the authorities. In-depth, semi-structured interviews were conducted over two years by both researchers with 25 social workers, recruited by the snowball method. The interview guidelines included one open-ended question and 10 more-specific questions. Findings The findings provide perspectives on postcolonial social work and social work with indigenous peoples. The social workers report that they are caught between their personal values and professional values, between Israeli law and the institutional aggression against their clients –which greatly limits their ability to fulfil their professional role. They say they are working in a “grey area” in which the policy is unclear. This adds another layer of complexity to their work but also allows for freedom and creativity. The findings point to a lack of suitable intervention programs. Applications Learning about the experience of social workers in conflict areas Learning about the experience of social workers in a clash of values Learning about the significance of unclear policy and its implications for the functioning of social workers in conflict areas.
Three-dimensional analysis of lateral cortical hinge in medial open-wedge high tibial osteotomy: A computational simulation study of adult cadavers
Authors: Jung Gu-Hee , Lee Kyung-Ho , Wang Lih 
Published: September 2020

Purpose: The objective of this study was to improve the three-dimensional (3D) understanding of optimal lateral cortical hinge in medial open-wedge high tibial osteotomy (MOWHTO) via a computational cadaveric simulation of actual size. Methods: The computed tomography data of 117 adult cadavers were imported into Mimics® software to design 3D models of tibia and fibula. To simulate the MOWTHO, a virtual cutting plane was developed inside the safe zone based on established landmarks. After splitting and distracting through the cutting plane, the 10-mm cylinder (Ø 30 mm; height 10 mm) was placed vertically to be occupied properly in the nonosteotomized lateral cortex. The cross points between the round cylinder and cutting plane represented the anterior and posterior hinge points, which were used to validate the 3D position and direction of cortical hinge. Results: A 10-mm cylinder did not violate the proximal tibiofibular joint (PTFJ) and the protruding segment of the condylar area was less than 2 mm in 115 models. The connecting line between anterior and posterior hinge points was an average of 12.1° (range 0–24.1°, SD 4.64) to the lateral side. In the nonoverlapping anteroposterior projection between proximal fibula and tibia, the posterior hinge point was laid over the PTFJ as close as possible. Based on free 360° rotation and magnification without any tilt, no posterior cortical disruption of PTFJ was observed while securing a minimum width of 10 mm. Conclusion: If the posterior hinge point was placed immediately above the PTFJ without involvement, the nonosteotomized portion carried sufficient width greater than 10 mm, despite lateral rotation at an average hinge direction of 12.1°.