bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological linkage among successful high-status women in international teams
Authors: Thorson Katherine R , Dumitru Oana D , West Tessa V 
Published: August 2020

AbstractIn contemporary society, decisions are often made by teams whose members represent different nationalities and genders. In the current work, participants from 55 countries formed groups of 3 to 4 people to select one of the 5 firms in a mock firm search. In all groups, one woman was randomly assigned to have higher status than her groupmates; she was also surreptitiously instructed to persuade her group to select one (randomly assigned) firm. We measured cardiac interbeat intervals for participants throughout the decision-making process to assess physiological linkage—the degree to which a ‘sender’s’ physiological response predicts a ‘receiver’s’ physiological response at a subsequent time interval. On average, high-status women were successful at persuasion. The physiological responses of successful high-status women were also predicted by the responses of their female groupmates: stronger linkage to female group members during the task was associated with success at persuading the group. Successful high-status women were also perceived as more persuasive than others in the group. This work shows that the link between status and successful persuasion generalizes to women among heterogeneous international teams. It also suggests that attention to others—often associated with physiological linkage—may be useful in persuading others during decision-making.
Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Authors: Leptourgos Pantelis , Fortier-Davy Martin , Carhart-Harris Robin , Corlett Philip R , Dupuis David , Halberstadt Adam L , Kometer Michael , Kozakova Eva , LarØi Frank , Noorani Tehseen N , Preller Katrin H , Waters Flavie , Zaytseva Yuliya , Jardri Renaud 
Published: August 2020

AbstractThe recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
Implementing Precision Psychiatry: A Systematic Review of Individualized Prediction Models for Clinical Practice
Authors: Salazar de Pablo Gonzalo , Studerus Erich , Vaquerizo-Serrano Julio , Irving Jessica , Catalan Ana , Oliver Dominic , Baldwin Helen , Danese Andrea , Fazel Seena , Steyerberg Ewout W , Stahl Daniel , Fusar-Poli Paolo 
Published: August 2020

Abstract

Background
The impact of precision psychiatry for clinical practice has not been systematically appraised. This study aims to provide a comprehensive review of validated prediction models to estimate the individual risk of being affected with a condition (diagnostic), developing outcomes (prognostic), or responding to treatments (predictive) in mental disorders.

Methods
PRISMA/RIGHT/CHARMS-compliant systematic review of the Web of Science, Cochrane Central Register of Reviews, and Ovid/PsycINFO databases from inception until July 21, 2019 (PROSPERO CRD42019155713) to identify diagnostic/prognostic/predictive prediction studies that reported individualized estimates in psychiatry and that were internally or externally validated or implemented. Random effect meta-regression analyses addressed the impact of several factors on the accuracy of prediction models.

Findings
Literature search identified 584 prediction modeling studies, of which 89 were included. 10.4% of the total studies included prediction models internally validated (n = 61), 4.6% models externally validated (n = 27), and 0.2% (n = 1) models considered for implementation. Across validated prediction modeling studies (n = 88), 18.2% were diagnostic, 68.2% prognostic, and 13.6% predictive. The most frequently investigated condition was psychosis (36.4%), and the most frequently employed predictors clinical (69.5%). Unimodal compared to multimodal models (β = .29, P = .03) and diagnostic compared to prognostic (β = .84, p &lt; .0001) and predictive (β = .87, P = .002) models were associated with increased accuracy.

Interpretation
To date, several validated prediction models are available to support the diagnosis and prognosis of psychiatric conditions, in particular, psychosis, or to predict treatment response. Advancements of knowledge are limited by the lack of implementation research in real-world clinical practice. A new generation of implementation research is required to address this translational gap.
The Strange Fate of the Dáil Decrees of Revolutionary Ireland, 1919–22
Authors: Mohr Thomas 
Published: August 2020

Abstract
This article examines the attempts at legislation in Ireland made by an elected assembly known as ‘Dáil Éireann’ in the revolutionary years between 1919 and 1922. These attempts at legislation, popularly known as ‘Dáil decrees’, have not been published or used as sources of law since the foundation of the Irish state on 6 December 1922. This analysis builds on a pioneering article on this subject published in 1975 by Brian Farrell and attempts to provide additional information on the final fate of the Dáil decrees. The conclusion argues that the fate of this legislation was not, as has been suggested, dictated by divisions created by the Irish civil war of 1922–23. Instead, this analysis concludes that the Dáil decrees faced insuperable practical barriers that could not be overcome after the foundation of the state in 1922.
Urban Space as a Factor of Production: Accounting for the Success of Small Factories in Postwar Tokyo
Authors: BANSAL Benjamin 
Published: August 2020

AbstractThis paper demonstrates that small manufacturing firms in postwar Tokyo were exceptionally successful. Not only were they more productive than their national peers, they were also remarkably competitive vis-à-vis large factories in Tokyo. The existing explanations for this double outperformance do not take full account of the urban setting in which this process took place. Small factories compensated for higher labor costs by being more efficient users of urban space. They thrived thanks to Tokyo’s particular urban form, which included a preference for mixed use and often blurred the boundaries between living and workplace. Small factories also benefited from being embedded in the relatively egalitarian structure of postwar Tokyo, as the city avoided spatial stratification despite megacity growth. Although Tokyo’s small factories remain important, their competitive edge has eroded from the 1970s onward.
Time-lagged and acute impact of heat stress on production and fertility traits in the local dual-purpose cattle breed “Rotes Höhenvieh” under pasture-based conditions
Authors: Halli Kathrin , Brügemann Kerstin , Bohlouli Mehdi , König Sven 
Published: August 2020

Abstract
Climate change causes rising temperatures and extreme weather events worldwide, with possible detrimental time-lagged and acute impact on production and functional traits of cattle kept in outdoor production systems. The aim of the present study was to infer the influence of mean daily temperature humidity index (mTHI) and number of heat stress days (nHS) from different recording periods on birth weight (BWT), 200 d- and 365 d-weight gain (200 dg, 365 dg) of calves, and on the probability of stillbirth (SB), and calving interval (CINT) of their dams. Data recording included 4,362 observations for BWT, 3,136 observations for 200 dg, 2,502 observations for 365 dg, 9,293 observations for the birth status, and 2,811 observations for CINT of the local dual-purpose cattle breed “Rotes Höhenvieh” (RHV). Trait responses on mTHI and nHS were studied via generalized linear mixed model applications with identity link functions for Gaussian traits (BWT, 200 dg, 365 dg, CINT) and logit link functions for binary SB. High mTHI and high nHS before autumn births had strongest detrimental impact on BWT across all antepartum- (a.p.) periods (34.4 ± 0.79 kg maximum). Prolonged CINT was observed when cows suffered heat stress (HS) before or after spring calvings, with maximum length of 391.6 ± 3.82 d (56 d a.p.-period). High mTHI and high nHS during the 42 d- and 56 d a.p.-period implied increased probabilities for SB. We found a significant (P &lt; 0.05) seasonal effect on SB in model 3 across all a.p.-periods, with the highest probability in autumn (maximum of 5.4 ± 0.82% in the 7 d a.p.-period). Weight gains of calves (200 dg and 365 dg) showed strongest HS response for mTHI and nHS measurements from the long-term postnatal periods (42 d- and 56 d-periods), with minimum 200 dg of 194.2 ± 4.15 kg (nHS of 31 to 42 d in the 42 d-period) or minimum 365 dg of 323.8 ± 3.82 kg (mTHI ≥ 60 in the 42 d-period). Calves born in summer, combined with high mTHI or high nHS pre- or postnatal, had lower weight gains, compared with calves born in other calving seasons or under cooler conditions. Highest BWT, weight gains, and shortest CINT mostly were detected under cool to moderate climate conditions for mTHI, and small to moderate nHS. Results indicate acute and time-lagged HS effects and address possible HS-induced epigenetic modifications of the bovine genome across generations and limited acclimatization processes to heat, especially when heat occurs during the cooler spring and autumn months.
Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
Authors: Zhang Chuangchuang , Wu Qian , Liu Hongshuai , Cheng Liam , Hou Zhipeng , Mori Susumu , Hua Jun , Ross Christopher A , Zhang Jiangyang , Nopoulos Peggy C , Duan Wenzhen 
Published: August 2020

Abstract
Emerging cellular and molecular studies are providing compelling evidence that altered brain development contributes to the pathogenesis of Huntington’s disease (HD). There has been lacking longitudinal system-level data obtained from in vivo HD models supporting this hypothesis. Our human MRI study in children and adolescents with HD indicates that striatal development differs between the HD and control groups, with initial hypertrophy and more rapid volume decline in HD group. In this study, we aimed to determine whether brain development recapitulates the human HD during the postnatal period. Longitudinal structural MRI scans were conducted in the heterozygous zQ175 HD mice and their littermate controls. We found that male zQ175 HD mice recapitulated the region-specific abnormal volume development in the striatum and globus pallidus, with early hypertrophy and then rapidly decline in the regional volume. In contrast, female zQ175 HD mice did not show significant difference in brain volume development with their littermate controls. This is the first longitudinal study of brain volume development at the system level in HD mice. Our results suggest that altered brain development may contribute to the HD pathogenesis. The potential effect of gene therapies targeting on neurodevelopmental event is worth to consider for HD therapeutic intervention.
Modulation of the Earliest Component of the Human VEP by Spatial Attention: An Investigation of Task Demands
Authors: Mohr Kieran S , Carr Niamh , Georgel Rachel , Kelly Simon P 
Published: August 2020

Abstract
Spatial attention modulations of initial afferent activity in area V1, indexed by the first component “C1” of the human visual evoked potential, are rarely found. It has thus been suggested that early modulation is induced only by special task conditions, but what these conditions are remains unknown. Recent failed replications—findings of no C1 modulation using a certain task that had previously produced robust modulations—present a strong basis for examining this question. We ran 3 experiments, the first to more exactly replicate the stimulus and behavioral conditions of the original task, and the second and third to manipulate 2 key factors that differed in the failed replication studies: the provision of informative performance feedback, and the degree to which the probed stimulus features matched those facilitating target perception. Although there was an overall significant C1 modulation of 11%, individually, only experiments 1 and 2 showed reliable effects, underlining that the modulations do occur but not consistently. Better feedback induced greater P1, but not C1, modulations. Target-probe feature matching had an inconsistent influence on modulation patterns, with behavioral performance differences and signal-overlap analyses suggesting interference from extrastriate modulations as a potential cause.
Prevalence and genotype distribution of human papillomavirus infection in Huzhou City, eastern China, 2018–2019
Authors: Zhu Yurong , Qian Fuchu , Zou Weihua , Wu Xiaoyun , Liu Chunlin , Shen Guosong , Lai Shiping , Yang Sheng 
Published: August 2020

Abstract

Background
Human papillomavirus (HPV) infection is involved in cervical cancer development, and hence understanding its prevalence and genotype distribution is important. However, there are few reports on the prevalence and genotype distribution of HPV in the city of Huzhou in China.

Methods
In this retrospective cross-sectional study, 11,506 women who visited Huzhou Maternity & Child Health Care Hospital between January 2018 and October 2019 were enrolled. The results of HPV genotyping and cytology tests were analyzed.

Results
The overall prevalence of HPV infection was 15.5%. The rate of high-risk (HR) HPV infection (13.5%) was higher than that of single low-risk (LR) HPV infection (2.0%) (p&lt;0.05). The five most common HPV genotypes were HPV52 (3.3%), 16 (1.9%), 58 (1.7%), 53 (1.5%), and 81 (1.2%). The infection rate of HPV peaked in women aged 16–24 and women aged ≥55. The infection rate of HPV58 or HPV81 appeared as a single peak in women aged ≥55. The rates of HR-HPV and LR-HPV infection were higher in subjects with abnormal cytology (p&lt;0.05).

Conclusions
HPV infection is high in Huzhou, and HPV53 and HPV81 are the prevalent genotypes. HPV infection rate is associated with age and cytology. Regional HPV surveillance is essential to optimize current HPV prevention and vaccine development.
Reproductive risk factors for angiographic obstructive coronary artery disease among postmenopausal women
Authors: Wen Jingyi , Shuai Wei , Ding Ting , Feng Yanzhi , Zhang Jinjin , Wang Shixuan 
Published: August 2020

Abstract

Objective:
Reproductive factors are female-specific coronary artery disease (CAD) risk factors. However, the importance of reproductive factors in angiographic obstructive CAD in postmenopausal women remains uncertain. This study aimed to compare reproductive factors between postmenopausal women with no apparent CAD, nonobstructive CAD, and obstructive CAD and identify reproductive risk factors for obstructive CAD.

Methods:
In this hospital-based cross-sectional study, 1,474 postmenopausal women, admitted with chest pain and referred for invasive coronary angiography were enrolled between April 2013 and October 2018.

Results:
Adjusted odds ratio (95% CI) for obstructive CAD were 1.81 (1.03-3.17) for multigravidity (three or more pregnancies), 1.77 (1.14-2.76) for early menopause (≤40 y old), and 1.72 (1.26-2.35) for short reproductive life span (≤30 y). Each additional year in age at menopause or reproductive life span was associated with a 4% reduction in obstructive CAD risk in postmenopausal women (odds ratio, 0.96; 95% CI, 0.94-0.99; P = 0.011). The other reproductive factors, including parity, age at first birth, spontaneous abortion, induced abortion, stillbirth, hypertensive disorders of pregnancy, gestational diabetes mellitus, and age at menarche, were not correlated with obstructive CAD risk in postmenopausal women.

Conclusions:
Multigravidity (three or more pregnancies), early menopause, and a shorter reproductive life span were independent risk factors of angiographic obstructive CAD among postmenopausal women, which suggested that pregnancy and ovarian function may be important for the early identification and prevention of increased risk of female angiographic obstructive CAD.
Shedding Light on COVID-19: ADAM17 the Missing Link?
Authors: Schreiber Brittany , Patel Ankit , Verma Ashish 
Published: August 2020

Background:
Coronavirus disease 2019 (COVID-19) is a rapidly expanding global health crisis. A disintegrin and metalloproteinase 17 (ADAM17), an ectodomain sheddase, is a key component of ACE2 modulation and plays a complex role in inflammation and immunosurveillance.

Areas of Uncertainty:
Much remains unknown regarding the immunopathogenesis of COVID-19, including how the virus affects ADAM17 expression, activity, and regulation.

Search Strategy:
Three electronic databases (MEDLINE through PubMed, Embase through Ovid, and Google Scholar) were searched to identify articles relevant to ADAM17 and severe acute respiratory syndrome coronavirus 1 and 2. Relevant articles published from January 1, 2005, to April 30, 2020, were selected, and reference lists were screened and cross-referenced. We also searched preprint studies on medRxiv and bioRxiv given the rapidly evolving data on COVID-19 SARS-CoV-2.

Therapeutic Opinion:
Infection with SARS-CoV-2 may lead to an increase in ADAM17 sheddase activity contributing to an exuberant macrophage-predominant inflammatory response and diminished immunosurveillance capacity for viral clearance. Emerging data suggest severe lung injury in COVID-19 is associated with higher levels of TNF-α and IL-6, T-cell lymphopenia and exhaustion, hypercoagulability, and a macrophage-predominant immune response. This clinical picture is consistent with dysregulation of many of the molecular pathways in which ADAM17 participates.

Conclusions:
Elucidation of the role of ADAM17 in COVID-19 may identify novel molecular targets for drug development and therapeutic repurposement.
Day-to-Day Variability of Walking Performance Measures in Individuals Poststroke and Individuals With Parkinson Disease
Authors: Holleran Carey L. , Bland Marghuretta D. , Reisman Darcy S. , Ellis Terry D. , Earhart Gammon M. , Lang Catherine E. 
Published: August 2020

Background and Purpose:
Improvement of walking performance is a primary goal for individuals poststroke or with Parkinson disease (PD) who receive physical therapy. More data about day-to-day variability of walking performance are critical for determining if changes in performance have occurred.

Methods:
Baseline assessments were utilized from an ongoing, observational, prospective cohort study including 84 individuals poststroke (n = 37) or with PD (n = 47) receiving outpatient physical therapy services to improve mobility. Participants wore step activity monitors for up to 7 days to measure walking performance (steps per day, walking duration, maximum 30-minute output, and peak activity index) in daily life. Correlation analyses evaluated relationships between both capacity and performance measures as well as the relationships between mean performance variables and day-to-day variability. Regression analyses explored factors that contribute to variability in day-to-day performance variables.

Results:
Mean steps per day for participants poststroke (5376 ± 2804) and with PD (8149 ± 4490) were consistent with previously reported cohorts. Greater amounts of walking were related to more day-to-day variability, with moderate correlations found between the mean and day-to-day variability of each performance measure, regardless of medical diagnosis or walking speed. Day-to-day variability is large (upwards of 50% of the mean), with the amount of walking performance serving as the primary predictor of day-to-day variability in walking performance.

Discussion and Conclusions:
The results of this study elucidate the factors that are related to and predict day-to-day variability of performance. Walking performance metrics should be evaluated over multiple days and greater variability should be anticipated with greater amounts of performance.

Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A319).
A new species of leaf fish,Nandus banshlaii(Perciformes: Nandidae) from West Bengal, India
Authors: Kapuri R. , Sinha A. K. , de P. , Roy R. , Bhakat S. 
Published: August 2020

AbstractNandus banshlaii, sp. nov. is described from the Banshlai River of West Bengal. This species is distinguished from all its congeners in having a golden brown body in live and a combination of characters like longest head and snout length (44.28% SL and 35.58% HL respectively) and from its two Indian congeners in containing largest eye diameter (22.22% HL), longest pre-dorsal length (47.16% SL), shortest pectoral fin length (14.60% SL) and smallest dorsal fin base length (45.53% SL).Like all three congeners of Ganga-Brahmaputra-Meghna river basin of Gangetic delta it possess a dark spot on caudal peduncle.To differentiate the present species from other two Indian congeners ofNandus,N. nandusandN. andrewi, PCA and heatmap is performed and a key of all three species is also provided.
Divergent use of metabolic fluxes in breast cancer metastasis
Authors: Mathur Deepti , Liao Chen , Ferlita Alessandro La , Alaimo Salvatore , Ferro Alfredo , Xavier Joao B. 
Published: August 2020

SummaryBreast cancers can metastasize to many organs. But how do disseminated cells from a primary tumor adapt to distal tissues? Here we combined metabolomics, flux measurements, and mathematical modeling to study metabolic fluxes in breast cancer cells adapted to home to different organs. We found that lung-homing cells maintain high glycolytic flux despite low levels of glycolytic intermediates, by constitutively activating a pathway sink into lactate. Their distinct behavior—a strong Warburg effect—has a gene expression signature: a high ratio of lactate dehydrogenase to pyruvate dehydrogenase gene expression, which also correlates with lung metastases in patients with breast cancer. Surprisingly, this strong Warburg effect does not necessarily increase cellular growth rate, suggesting that lactate secretion may be a trait under selection in lung metastasis. Our results stress that metabolic fluxes may not correlate with metabolic intermediates, a finding relevant for metastatic tropism.