bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haploidentical transplantation in high‐risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow transplantation in children (GETMON) and the Spanish Grupo for hematopoietic transplantation (GETH)
Authors: Pérez‐Martínez Antonio , Ferreras Cristina , Pascual Antonia , Gonzalez‐Vicent Marta , Alonso Laura , Badell Isabel , Fernández Navarro José María , Regueiro Alexandra , Plaza Mercedes , Pérez Hurtado Jose María , Benito Ana , Beléndez Cristina , Couselo José Miguel , Fuster José Luis , Díaz‐Almirón Mariana , Bueno David , Mozo Yasmina , Marsal Julia , Gómez López Alicia , Sisinni Luisa , de Heredia Cristina Díaz , Díaz Miguel Ángel 
Published: October 2019

AbstractA total of 192 pediatric patients, median age 8.6 years, with high‐risk hematological malignancies, underwent haploidentical stem cell transplantation (haplo‐HSCT) using post‐transplantation cyclophosphamide (PT‐Cy), or ex vivo T cell‐depleted (TCD) graft platforms, from January 1999 to December 2016 in 10 centers in Spain. Some 41 patients received an unmanipulated graft followed by PT‐Cy for graft‐vs‐host disease (GvHD) prophylaxis. A total of 151 patients were transplanted with CD3‐depleted peripheral blood stem cells (PBSCs) by either CD34+ selection, CD3+CD19+ depletion, TCRαβ+CD19+ depletion or CD45RA+ depletion, added to CD34+ selection for GvHD prophylaxis. The PBSCs were the only source in patients following ex vivo TCD haplo‐HSCT; bone marrow was the source in 9 of 41 patients following PT‐CY haplo‐HSCT. Engraftment was achieved in 91.3% of cases. A donor younger than 30 years, and the development of chronic GvHD were positive factors influencing survival, whereas positive minimal residual disease (MRD) before transplant and lymphoid disease were negative factors. The probability of relapse increased with lymphoid malignancies, a donor killer‐cell immunoglobulin‐like receptor (KIR) haplotype A and positive MRD pretransplant. No difference was found in overall survival, disease‐free survival or relapse incidence between the two platforms. Relapse is still of concern in both platforms, and it should be the focus of future efforts. In conclusion, both platforms for haplo‐HSCT were effective and could be utilized depending on the comfort level of the center.
Sustainable supply chain management and partner engagement to manage climate change information
Authors: Dahlmann Frederik , Roehrich Jens K. 
Published: October 2019

AbstractClimate change poses significant new risks and challenges for businesses and their supply chains. Additionally, in many sectors, Scope 3 indirect greenhouse gas emissions resulting from the sourcing and distribution of goods and services are larger than firms' own carbon footprints. Here we study how firms engage their key stakeholders in their supply chains in obtaining, processing, and transferring relevant climate change‐related information designed to overcome information asymmetry and drive sustainable development. Grounded in organisational information‐processing theory (OIPT), we draw on data from the Carbon Disclosure Project's Climate Change Supply Chain initiative for a qualitative content analysis of a large sample of global firms. Consistent with OIPT, we find that although firms primarily engage their supply chain partners in a variety of ways to reduce information uncertainty around indirect emissions data, effectively interpreting and managing broader sustainability information equivocality becomes a growing priority. Our findings further suggest that firms engage suppliers, customers, and other supply chain partners through basic, transactional, and collaborative types of engagement. We contribute to literatures on interorganisational information processing and sustainable supply chain management by providing a more detailed understanding of how firms engage supply chain partners in the context of climate change.
A Facile Synthesis of FeCo Nanoparticles Encapsulated in Hierarchical N‐Doped Carbon Nanotube/Nanofiber Hybrids for Overall Water Splitting
Authors: Aftab Faryal , Duran Hatice , Kirchhoff Katrin , Zaheer Muhammad , Iqbal Bushra , Saleem Murtaza , Arshad Salman N. 
Published: October 2019

AbstractDevelopment of efficient and cost‐effective transition metal‐based catalysts for overall water splitting is desired. Herein, a facile synthesis procedure for the development of FeCo bimetallic alloy nanoparticles (NPs) located on the tips of multi‐walled carbon nanotubes (CNTs) supported over N‐doped carbon nanofibers (CNFs) is presented. The CNTs, not only prevent FeCo NPs from agglomeration by encapsulating them at the tip but also provide an efficient electron pathway. The materials exhibited excellent performance in oxygen evolution reaction (OER) and decent activity in hydrogen evolution reaction (HER) with long‐term durability of up to 48 hours on glassy carbon electrode. The best OER activity with a overpotential of 283 mV@10 mAcm−2 and Tafel slope of 38 mV/dec was achieved with a hierarchically porous catalyst having Fe : Co molar ratio of 1 : 2. This synthesis approach is promising for growing well‐dispersed CNTs over N‐doped carbonaceous support using bimetallic alloys for electrocatalytic applications.
Improving Bed Movement Physics in Biomass Computational Fluid Dynamics Combustion Simulations
Authors: Varela Luis González , Bermúdez Cesar Álvarez , Chapela Sergio , Porteiro Jacobo , Tabarés José L. Míguez 
Published: October 2019

AbstractA detailed description of the first functional new approach to simulate the bed physics in biomass boilers in a Eulerian mathematical framework is presented. In particular, the analysis of the context of the collapse due to gravitational forces, the design of an automated algorithm that is responsible for its simulation under ANSYS‐Fluent, the concrete implementation of this algorithm, and its test with experimental contrasted data are described. The proposed solution can replicate the angle of repose of different fuels in biomass combustion boilers by implementing a series of geometric mechanisms applied to the mesh. The selected approach mainly responds to a computational efficiency requirement; both memory management and execution speed are relevant.
Integrated Ejector‐Based Flare Gas Recovery and On‐Site Desalination of Produced Water in Shale Gas Production
Authors: Mazumder Mozammel , Chen Liwen , Xu Qiang 
Published: October 2019

AbstractFlaring is a major concern in the oil and gas industry as it wastes valuable raw materials/energy and emits a substantial amount of air pollutants. The produced water treatment during oil and gas production is very troublesome due to its large processing volume, high salinity, and expensive disposal cost. Thus, the on‐site integration of the flaring gas recovery (FGR) and desalination processes for handling the produced water could not only monetize flare emission sources but could also generate freshwater for versatile usages. Here, a novel process was developed integrating the ejector‐based FGR (EFGR) process with the thermal vapor compression (TVC)‐based desalination process. The newly developed EFGR‐TVC process is shown to be technically viable and cost‐effective under normal operating conditions.
Von nichts, kommt nichts
Authors: Liebermeister Barbara 
Published: October 2019

AbstractDer Aufbau und die Pflege werthaltiger Geschäftsbeziehungen erfordert Zeit und Energie. Entsprechend systematisch sollten Unternehmer, Führungskräfte und Vertriebler beim Auf‐ und Ausbau ihres beruflichen Beziehungsnetzwerks vorgehen. Nicht nur das Knüpfen von Kontakten, sondern auch deren Pflege erfordert Zeit und Energie. Barbara Liebermeister, Leiterin des Frankfurter Instituts für Führungskultur im digitalen Zeitalter (IFIDZ) gibt hier einige Tipps, worauf beim systematischen Auf‐ und Ausbau von Geschäftsbeziehungen zu achten ist.
Schnell, schneller, digital
Authors: Hennecke Andreas 
Published: October 2019

AbstractFür moderne Prozessanlagen bedeutet der Einsatz digitaler Infrastruktur einen erheblichen Vorteil – vom verkürzten Go Live bis zur optimalen Fehlerkontrolle durch umfangreiche Diagnosedaten. Eine PROFINET auf PROFIBUS PA Applikation ist hier State of the Art und zukunftweisender Standard gleichermaßen.
Prozessleittechnik IT‐sicher machen
Authors: Fischer Klaus‐Michael , Weber Christian 
Published: October 2019

AbstractBetreiber von Prozessanlagen müssen neben den Prüfverpflichtungen aus der BetrSichV und der 12. BImSchV für überwachungspflichtige Anlagen regelmäßig die IT‐Risiken ihrer leittechnischen Sicherheitseinrichtungen beurteilen. Zudem sind teils konkurrierende Security‐ und Safety‐Anforderungen in der Umsetzung von PLT‐Sicherheitseinrichtungen zu vereinbaren. TüV SüD Chemie Service diskutiert diese Herausforderungen für PLT‐Betriebsingenieure und zeigt mögliche Herangehensweisen auf.
Vibrationsmessungen am Arbeitsplatz
Authors: Höchst Infraserv 
Published: October 2019

AbstractDie beiden Projektleiter im Schallschutz von Infraserv Höchst haben beim Institut für Arbeitsschutz den erstmalig angebotenen Fachkundenachweis mit Prüfung erfolgreich absolviert. Damit kann dem Kunden als akkreditierte Messstelle der deutschen Akkreditierungsstelle (DAkkS) eine ganzheitliche, kombinierte Untersuchung von Geräuschen und Schwingungen angeboten werden.
Die Geschichte des Ostromislensky‐Verfahrens
Authors: Requardt Axel 
Published: October 2019

Zusammenfassung1911 entdeckte Ostromislensky ein zweistufiges Verfahren, um aus Alkohol Butadien zu gewinnen. Diese Entdeckung wurde von ihm zunächst für so unbedeutend gehalten, dass er bis 1913 mit der Veröffentlichung wartete. Erst durch die vom Zaren im Juli 1914 verfügte Wodka‐Prohibition und dem damit verbundenen Problem, die riesigen Wodka‐Vorräte sinnvoll zu nutzen, rückte das Verfahren in den Fokus des Interesses. Der Prozess sollte das notwendige Butadien für die Produktion von Synthesekautschuk liefern. Pilotprojekte im Zarenreich und im sowjetischen Russland scheiterten aber. Erst um 1940 gelang es der Union Carbide in den USA, das Verfahren durch eine neue Katalysator‐Generation so zu optimieren, dass es während des zweiten Weltkrieges eine wichtige Rolle bei der Lösung der „US Kautschuk‐Krise“ spielte. Der benötigte Alkohol wurde dabei von Whiskey‐Brennereien geliefert. Die Geschichte des Ostromislensky‐Verfahrens ist also eine Geschichte zwischen Wodka und Whiskey.
Trajectories of social resource use among informal lung cancer caregivers
Authors: Litzelman Kristin , Reblin Maija , McDowell Helene E. , DuBenske Lori L. 
Published: October 2019

BackgroundSocial support is a key component in maintaining cancer caregiver well‐being, and many resources exist to facilitate caregivers' use of social support (eg, cancer support groups). This study sought to determine how informal cancer caregivers use social resources over the course of caregiving.MethodsThe data are from the Comprehensive Health Enhancement Support System study of informal caregivers (n = 202) of patients with recently diagnosed lung cancer. Caregivers self‐reported their sociodemographic and caregiving characteristics and social resource use over 6 months. Generalized additive models were used to assess social resource use over time, and generalized estimating equation logistic regression models were used to assess the correlates of social resource use.ResultsNearly two‐thirds of caregivers reported any social resource use. The most prevalent social resources were faith‐based groups (38%) and social clubs (30%). Only 1 in 4 caregivers participated in a formal resource such as counseling (11%) or a cancer support group (6%). Social resource use was lowest immediately after the diagnosis and increased over time. Formal resource use exhibited a nonlinear association with time such that formal resource use peaked approximately 9 to 10 months after the cancer diagnosis. Caregivers were more likely to report social resource use if the patient also reported social engagement.ConclusionsThis study has found that many cancer caregivers do not use social resources, although social resource use increases over time after the cancer diagnosis. Because of the association between social engagement and well‐being, this information may inform future research and interventions to improve outcomes for cancer caregivers and their families.
The impact of underinsurance on bladder cancer diagnosis, survival, and care delivery for individuals under the age of 65 years
Authors: Fletcher Sean A. , Cole Alexander P. , Lu Chang , Marchese Maya , Krimphove Marieke J. , Friedlander David F. , Mossanen Matthew , Kilbridge Kerry L. , Kibel Adam S. , Trinh Quoc‐Dien 
Published: October 2019

BackgroundHealth insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status.MethodsThe Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to identify individuals younger than 65 years who were diagnosed with bladder cancer from 2007 to 2014. The associations between the insurance status (privately insured, insured by Medicaid, or uninsured) and the following outcomes were evaluated: diagnosis with advanced disease, cancer‐specific survival, delay in treatment longer than 90 days, treatment in a high‐volume hospital, and receipt of neoadjuvant chemotherapy (NAC).ResultsCompared with those with private insurance, uninsured and Medicaid‐insured individuals were nearly twice as likely to receive a diagnosis of muscle‐invasive bladder cancer (odds ratio [OR] for uninsured individuals, 1.90; 95% confidence interval [CI], 1.70‐2.12; OR for Medicaid‐insured individuals, 2.03; 95% CI, 1.87‐2.20). They were also more likely to die of bladder cancer (adjusted hazard ratio [AHR] for uninsured individuals, 1.49; 95% CI, 1.31‐1.71; AHR for Medicaid‐insured individuals, 1.61; 95% CI, 1.46‐1.79). Delays in treatment longer than 90 days were more likely for uninsured (OR, 1.36; 95% CI, 1.12‐1.65) and Medicaid‐insured individuals (OR, 1.22; 95% CI, 1.03‐1.44) in comparison with the privately insured. Uninsured patients had lower odds of treatment at a high‐volume facility, and Medicaid‐insured patients had lower odds of receiving NAC (P < .001 for both).ConclusionsCompared with privately insured individuals, uninsured and Medicaid‐insured individuals experience worse prognoses and poorer care quality. Expanding high‐quality insurance coverage to marginalized populations may help to reduce the burden of this disease.
A Self‐Assembled Peptide‐Appended Naphthalene Diimide: A Fluorescent Switch for Sensing Acid and Base Vapors
Authors: Gayen Kousik , Basu Kingshuk , Nandi Nibedita , Sundar Das Krishna , Hermida‐Merino Daniel , Hamley Ian W. , Banerjee Arindam 
Published: October 2019

AbstractA histidine‐containing bola‐amphiphilic molecule (NDIP) containing a peptide‐appended naphthalenediimide (NDI) forms fluorescent hydrogels in phosphate buffer and organogels with benzenoid solvents. These gels were characterized by several spectroscopic and microscopic techniques including FT‐IR, HR‐TEM, powder X‐ray diffraction and small‐angle X‐ray scattering, UV‐Vis and fluorescence studies. The gelator molecule exhibits no significant fluorescence in the xerogel state, while it shows a significant fluorescence (bright cyan) in the presence of volatile organic/inorganic acid vapors; this cyan color vanishes in presence of base (ammonia vapors). A reusable paper‐strip‐based method based on this self‐assembled fluorescent material can be used to easily detect hazardous volatile acid and base vapors with the naked eye.
The (in)congruence of measures of corporate social responsibility performance and stakeholder measures of corporate social responsibility reputation
Authors: Yang Yoori , Stohl Cynthia 
Published: October 2019

AbstractA central proposition of the “business case” for corporate social responsibility (CSR) is that a company's CSR practices are linked to consumer behavior and a firm's financial performance through reputational mechanisms. This study addresses the equivocal support for this proposition through an empirical analysis of the survey items most often used to assess a company's CSR and its stakeholder reputation. This study tests the congruence among nine different measures of environmental, social, and governance dimensions of CSR and a public corporate reputation measure. Two distinct factors are identified—direct CSR impact and assessment/reputation—suggesting that the global corporate reputation does not capture tangible CSR impact (environment and social) and is only congruent with a measure of intangible CSR performance (governance). The study highlights the importance of taking a multidimensional approach. Addressing measurement issues helps unpack the theoretical and practical link between CSR and corporate reputation and provides strategic guidance when planning CSR business and communication strategies.
A novel proximity graph: Circular neighborhood cell graph for histopathological tissue image analyzing
Authors: Serin Faruk , Erturkler Metin 
Published: October 2019

AbstractThe cell is the smallest unit of living beings, which has structural and functional properties. Almost all cell behaviors are regulated by various intracellular reactions initiated by the signaling. The signaling and the distance between cells influence each other. Thus, cell‐location‐based modeling and analyzing of histopathological tissues provide important information to the expert. In literature, methods such as distance‐based threshold, K‐Nearest Neighbor, Voronoi graphs, Delaunay triangulation, and colored graph have been used. However, circular neighborhood relationships of cells have not been considered by any CAD system so far despite of its crucial impact. Thus, we developed the circular neighborhood cell‐graph. Histopathological images of liver were classified by using features extracted from T‐Distance, K‐Nearest Neighbor, Voronoi, Delaunay, and the proposed cell‐graph. Then, the classification performances of the methods were compared. Experimental results show that liver tissue images can be classified with accuracy of 95.7% by using the features provided by the proposed cell‐graph model.
Novel SPEG variant cause centronuclear myopathy in China
Authors: Tang Jia , Ma Wei , Chen Yangran , Jiang Runze , Zeng Qinlong , Tan Jieliang , Jiang Hongqing , Li Qing , Zhang Victor W. , Wang Jing , Tang Hui , Luo Liangping 
Published: October 2019

AbstractBackgroundCentronuclear myopathy (CNM), a subtype of congenital myopathy (CM), is a group of clinical and genetically heterogeneous muscle disorders. Centronuclear myopathy is a kind of disease difficult to diagnose due to its genetic diversity. Since the discovery of the SPEG gene and disease‐causing variants, only a few additional patients have been reported.MethodsA radiograph test, ultrasonic test, and biochemical tests were applied to clinical diagnosis of CNM. We performed trio medical exome sequencing of the family and conservation analysis to identify variants.ResultsWe report a pair of severe CNM twins with the same novel homozygous SPEG variant c. 8710A>G (p.Thr2904Ala) identified by clinical trio medical exome sequencing of the family and conservation analysis. The twins showed clinical symptoms of facial weakness, hypotonia, arthrogryposis, strephenopodia, patent ductus arteriosus, and pulmonary arterial hypertension.ConclusionsOur report expands the clinical and molecular repertoire of CNM and enriches the variant spectrum of the SPEG gene in the Chinese population and helps us further understand the pathogenesis of CNM.
Separation of 5‐aminovalerate from its bioconversion liquid by macroporous adsorption resin: mechanism and dynamic separation
Authors: Xu Sheng , Lu Xuedong , Li Mei , Wang Jing , Li Hui , He Xun , Feng Jiao , Wu Jinglan , Chen Kequan , Ouyang Pingkai 
Published: October 2019

AbstractBACKGROUND5‐aminovalerate (5‐AVA) is the precursor of valerolactam, a potential building block for producing nylon 5, and also regarded as a potential C5 chemical platform. Although 5‐AVA bioproduction has been developed, few studies have emphasized the separation of 5‐AVA from the bioconversion liquid.RESULTSAn effective and benign method for separation of 5‐AVA from its bioconversion liquid was proposed based on chromatography technology using macroporous adsorption resin AK‐1. This work focuses on explosion of the adsorption mechanism and optimization of the operating conditions. Freundlich model and thermodynamics results showed that the adsorption affinity of 5‐AVA to the AK‐1 resin was weaker than that of l‐lysine. Combination of the characterization results of AK‐1 resin with the physicochemical properties of 5‐AVA and l‐lysine, the adsorption mechanism was proposed as meso‐micropore diffusion, and hydrogen bonding and hydrophobic effects. In dynamic studies, a 5‐AVA purity of 99.3% and yield of 92% was obtained at an operating temperature of 353.15 K on a 40:1 chromatographic column eluted by deionized water. The residual 5‐AVA and l‐lysine were recovered by 1 mol L–1 HCl, which can be used as a feed material in the 5‐AVA conversion process repeatedly.CONCLUSIONAn innovative benign efficient environmentally process for recovery of 5‐AVA from the bioconversion liquid was developed based on a macroporous resin AK‐1. Compared with ion exchange resins, macroporous resins can efficiently adsorb 5‐AVA, whereas salt ions cannot be retained. This clean and efficient method provides a promising strategy for separating similar biochemical products. © 2019 Society of Chemical Industry
Investment of both essential fatty and amino acids to immunity varies depending on reproductive stage
Authors: Pettit Taylor V. , Pettit R. John , Durso Andrew M. , French Susannah S. 
Published: October 2019

AbstractTrade‐offs among the key life‐history traits of reproduction and immunity have been widely documented. However, the currency in use is not well‐understood. We investigated how reproducing female side‐blotched lizards, Uta stansburiana, allocate lipids versus proteins when given an immune challenge. We tested whether lizards would invest more in reproduction or immunity depending on reproductive stage. Females were given stable isotopes (15N‐leucine and 13C‐1‐palmitic acid), maintained on a regular diet and given either a cutaneous biopsy or a sham biopsy (control). Stable isotopes were monitored and analyzed in feces and uric acid, skin biopsies, eggs, and toe clips. We found that lizards deposited both proteins and lipids into their healing wounds (immune‐challenged), skin (control), and eggs (all) and that catabolism of proteins exceeded incorporation into tissue during wound‐healing. Specifically, we found that healed biopsies of wounded animals had more leucine and palmitic acid than the nonregrown skin biopsies taken from unwounded control animals. Earlier in reproduction, lizards invested relatively more labeled proteins into healing their wound tissue, but not into unwounded skin of control animals. Thus, reproduction is sometimes favored over self‐maintenance, but only in later reproductive stages. Finally, we documented positive relationships among the amount of palmitic acid deposited in the eggs, the amount of food eaten, and the amount of palmitic acid excreted, suggesting higher turnover rates of lipids in lizards investing highly in their eggs.