bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can social accountability improve access to free public health care for the poor? Analysis of three Health Equity Fund configurations in Cambodia, 2015–17
Authors: Jacobs Bart , Sam Oeun Sam , Ir Por , Rifkin Susan , Van Damme Wim 
Published: February 2020

AbstractWithin the context of universal health coverage, community participation has been identified as instrumental to facilitate access to health services. Social accountability whereby citizens hold providers and policymakers accountable is one popular approach. This article describes one example, that of Community-Managed Health Equity Funds (CMHEFs), as an approach to community engagement in Cambodia to improve poor people’s use of their entitlement to fee-free health care at public health facilities. The objectives of this article are to describe the size of its operations and its ability to enable poor people continued access to health care. Using data collected routinely, we compare the uptake of curative health services by eligible poor people under three configurations of Health Equity Funds (HEFs) during a 24-month period (July 2015–June 2017): Standard HEF that operated without community engagement, Mature CMHEFs established years before the study period and New CMHEFs initiated just before the study period. One year within the study, non-governmental organizations (NGOs) stopped operating the HEF nationwide and only the community-participation aspects of New CMHEF continued receiving technical assistance from an NGO. Using utilization figures for curative services by non-poor people for comparison, following the cessation of HEF management by the NGOs, outpatient consultation figures declined for all three configurations in comparison with the year before but only significantly for Standard HEF. The three HEF configurations experienced a highly statistically significant reduction in monthly inpatient admissions following halting of NGO management of HEFs. This study shows that enhancing access to free health care through social accountability is optimized at health centres through engagement of a wide range of community representatives. Such effect at hospitals was only observed to a limited extent, suggesting the need for more engagement of hospital management authorities in social accountability mechanisms.
Long-Acting Cabotegravir Protects Macaques Against Repeated Penile Simian-Human Immunodeficiency Virus Exposures
Authors: Dobard Charles , Makarova Natalia , Nishiura Kenji , Dinh Chuong , Holder Angela , Sterling Mara , Lipscomb Jonathan , Mitchell James , Deyounks Frank , Garber David , Khalil George , Spreen William , Heneine Walid , García-Lerma J Gerardo 
Published: February 2020

Abstract
We used a novel penile simian-human immunodeficiency virus (SHIV) transmission model to investigate whether long-acting cabotegravir (CAB LA) prevents penile SHIV acquisition in macaques. Twenty-two macaques were exposed to SHIV via the foreskin and urethra once weekly for 12 weeks. Of these, 6 received human-equivalent doses of CAB LA, 6 received oral emtricitabine/tenofovir disoproxil fumarate, and 10 were untreated. The efficacy of CAB LA was high (94.4%; 95% confidence interval, 58.2%–99.3%) and similar to that seen with oral emtricitabine/tenofovir disoproxil fumarate (94.0%; 55.1%–99.2%). The high efficacy of CAB LA in the penile transmission model supports extending the clinical advancement of CAB LA preexposure prophylaxis to heterosexual men.
Global Monetary Order and the Liberal Order Debate
Authors: Norrlof Carla , Poast Paul , Cohen Benjamin J , Croteau Sabreena , Khanna Aashna , McDowell Daniel , Wang Hongying , Winecoff W Kindred 
Published: February 2020

AbstractThe recent “liberal international order” (LIO) debate has been vague about the institutions and issue areas that constitute the order. This is likely driven by competing views of “liberal” and, perhaps more importantly, by security scholars dominating the debate. From the perspective of scholars who explore the elements of the global monetary order (reserve currencies, international financial institutions, and central banks), the picture is different. Where security scholars point to a decline in US influence, scholars of global monetary politics see continued US dominance. Moreover, monetary prominence has been a precondition for the viability of great power projects of order building more generally. This symposium offers such a counter narrative. While the security challenges are real, the crises of the last decade have actually reinforced the centrality of the US dollar and American financial power in the international system.
Efficacy of continuous versus intermittent administration of nanoformulated benznidazole during the chronic phase of Trypanosoma cruzi Nicaragua infection in mice
Authors: Rial M S , Arrúa E C , Natale M A , Bua J , Esteva M I , Prado N G , Laucella S A , Salomon C J , Fichera L E 
Published: February 2020

Abstract

Background
Benznidazole and nifurtimox are effective drugs used to treat Chagas’ disease; however, their administration in patients in the chronic phase of the disease is still limited, mainly due to their limited efficacy in the later chronic stage of the disease and to the adverse effects related to these drugs.

Objectives
To evaluate the effect of low doses of nanoformulated benznidazole using a chronic model of Trypanosoma cruzi Nicaragua infection in C57BL/6J mice.

Methods
Nanoformulations were administered in two different schemes: one daily dose for 30 days or one dose every 7 days, 13 times.

Results
Both treatment schemes showed promising outcomes, such as the elimination of parasitaemia, a reduction in the levels of T. cruzi-specific antibodies and a reduction in T. cruzi-specific IFN-γ-producing cells, as well as an improvement in electrocardiographic alterations and a reduction in inflammation and fibrosis in the heart compared with untreated T. cruzi-infected animals. These results were also compared with those from our previous work on benznidazole administration, which was shown to be effective in the same chronic model.

Conclusions
In this experimental model, intermittently administered benznidazole nanoformulations were as effective as those administered continuously; however, the total dose administered in the intermittent scheme was lower, indicating a promising therapeutic approach to Chagas’ disease.
Autonomy, Consent, and the “Nonideal” Case
Authors: Lillehammer Hallvard 
Published: February 2020

AbstractAccording to one influential view, requirements to elicit consent for medical interventions and other interactions gain their rationale from the respect we owe to each other as autonomous, or self-governing, rational agents. Yet, the popular presumption that consent has a central role to play in legitimate intervention extends beyond the domain of cases where autonomous agency is present to cases where far from fully autonomous agents make choices that, as likely as not, are going to be against their own best interest. The question of how we should understand the rationale for eliciting consent in this range of “nonideal” cases is comparatively ill understood. In this paper, I explore the prospects of accounting for consent requirements in such “nonideal” cases by appealing to a set of agency-based interests, including an interest in playing a meaningful part in joint decisions affecting ourselves and others.
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases
Authors: Trejo-Lopez Jorge A , Sorrentino Zachary A , Riffe Cara J , Prokop Stefan , Dickson Dennis W , Yachnis Anthony T , Giasson Benoit I 
Published: February 2020

Abstract
Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator, across neurodegenerative proteinopathies. In this study, 2 novel mouse-derived monoclonal antibodies 5G3 and 2A5 raised against residues 360–380 of human p62/sequestosome-1 were characterized via immunohistochemical application upon human tissues derived from cases of C9orf72-expansion spectrum diseases, Alzheimer disease, progressive supranuclear palsy, Lewy body disease, and multiple system atrophy. 5G3 and 2A5 reliably highlighted neuronal dipeptide repeat, tau, and α-synuclein inclusions in a distribution similar to a polyclonal antibody to p62, phospho-tau antibodies 7F2 and AT8, and phospho-α-synuclein antibody 81A. However, antibodies 5G3 and 2A5 consistently stained less neuropil structures, such as tau neuropil threads and Lewy neurites, while 2A5 marked fewer glial inclusions in progressive supranuclear palsy. Both 5G3 and 2A5 revealed incidental astrocytic tau immunoreactivity in cases of Alzheimer disease and Lewy body disease with resolution superior to 7F2. Through their unique ability to highlight specific types of pathological deposits in neurodegenerative brain tissue, these novel monoclonal p62 antibodies may provide utility in both research and diagnostic efforts.
3D numerical experiment for EUV waves caused by flux rope eruption
Authors: Mei Z X , Keppens R , Cai Q W , Ye J , Xie X Y , Li Y 
Published: February 2020

ABSTRACTWe present a 3D magnetohydrodynamic numerical experiment of an eruptive magnetic flux rope (MFR) and the various types of disturbances it creates, and employ forward modelling of extreme ultraviolet (EUV) observables to directly compare numerical results and observations. In the beginning, the MFR erupts and a fast shock appears as an expanding 3D dome. Under the MFR, a current sheet grows, in which magnetic field lines reconnect to form closed field lines, which become the outermost part of an expanding coronal mass ejection (CME) bubble. In our synthetic SDO/AIA images, we can observe the bright fast shock dome and the hot MFR in the early stages. Between the MFR and the fast shock, a dimming region appears. Later, the MFR expands so its brightness decays and it becomes difficult to identify the boundary of the CME bubble and distinguish it from the bright MFR in synthetic images. Our synthetic images for EUV disturbances observed at the limb support the bimodality interpretation for coronal disturbances. However, images for disturbances propagating on-disc do not support this interpretation because the morphology of the bright MFR does not lead to circular features in the EUV disturbances. At the flanks of the CME bubble, slow shocks, velocity vortices and shock echoes can also be recognized in the velocity distribution. The slow shocks at the flanks of the bubble are associated with a 3D velocity separatrix. These features are found in our high-resolution simulation, but may be hard to observe as shown in the synthetic images.
Vertical distribution of HMXBs in NGC 55: constraining their centre-of-mass velocity
Authors: Politakis Babis , Zezas Andreas , Andrews Jeff J , Williams Stephen J 
Published: February 2020

ABSTRACT
We analyse the vertical distribution of high-mass X-ray binaries (HMXBs) in NGC 55, the nearest edge-on galaxy to the Milky Way (MW), based on X-ray observations by Chandra. Adopting a statistical approach, we estimate the difference between the scale height of the vertical distribution of HMXBs and the vertical distribution of star-forming activity between 0.33 and 0.57 kpc. The spatial offsets can be explained by a momentum kick the X-ray binaries receive during the formation of the compact object after a supernova explosion of the primary star. Determining the vertical distribution of HMXBs in the MW using Gaia DR2 astrometry, we find that the corresponding difference is considerably lower at 0.036 ± 0.003 kpc, attributed to the greater gravitational potential of the MW. We also calculate the centre-of-mass transverse velocities of HMXBs in NGC 55, using traveltime information from binary population synthesis codes and for different star formation histories (SFHs). For a flat SFH model (typical of spiral galaxies like NGC 55), we find that HMXBs are moving with a typical transverse velocity between 34 and 48 km s−1, consistent with space velocities of MW HMXBs. For an exponentially declining SFH model, HMXBs are moving at a velocity of 21 km s−1, consistent with the corresponding velocity of HMXBs in the Small Magellanic Cloud and Large Magellanic Cloud. Finally, we estimate the formation efficiency of HMXBs in NGC 55 at 299$_{-46}^{+50}$ (systems/M⊙ yr−1), consistent within the errors with the Magellanic Clouds but significantly higher than the MW, a difference that can be explained by the subsolar metallicity of NGC 55.
Dust dynamics and vertical settling in gravitoturbulent protoplanetary discs
Authors: Riols A , Roux B , Latter H , Lesur G 
Published: February 2020

Abstract
Gravitational instability (GI) controls the dynamics of young massive protoplanetary discs. Apart from facilitating gas accretion on to the central protostar, it must also impact on the process of planet formation: directly through fragmentation, and indirectly through the turbulent concentration of small solids. To understand the latter process, it is essential to determine the dust dynamics in gravitoturbulent flow. For that purpose, we conduct a series of 3D shearing box simulations of coupled gas and dust, including the gas’s self-gravity and scanning a range of Stokes numbers, from 10 −3 to ∼0.2. First, we show that the vertical settling of dust in the mid-plane is significantly impeded by gravitoturbulence, with the dust scale height roughly 0.6 times the gas scale height for centimetre grains. This is a result of the strong vertical diffusion issuing from (i) small-scale inertial-wave turbulence feeding off the GI spiral waves and (ii) the larger scale vertical circulations that naturally accompany the spirals. Second, we show that at R = 50 au concentration events involving submetre particles and yielding order 1 dust-to-gas ratios are rare and last for less than an orbit. Moreover, dust concentration is less efficient in 3D than in 2D simulations. We thus conclude that GI is not especially prone to the turbulent accumulation of dust grains. Finally, the large dust scale height measured in simulations could be, in the future, compared with that of edge-on discs seen by ALMA, thus aiding detection and characterization of GI in real systems.
The Tessellation-Level-Tree: characterizing the nested hierarchy of density peaks and their spatial distribution in cosmological N-body simulations
Authors: Busch Philipp , White Simon D M 
Published: February 2020

ABSTRACT
We use the Millennium and Millennium-II simulations to illustrate the Tessellation-Level-Tree  (tlt), a hierarchical tree structure linking density peaks in a field constructed by voronoi tessellation of the particles in a cosmological N-body simulation. The tlt uniquely partitions the simulation particles into disjoint subsets, each associated with a local density peak. Each peak is a subpeak of a unique higher peak. The tlt can be persistence filtered to suppress peaks produced by discreteness noise. Thresholding a peak’s particle list at $\sim 80\left \langle \rho \right \rangle \,$ results in a structure similar to a standard friend-of-friends halo and its subhaloes. For thresholds below $\sim 7\left \langle \rho \right \rangle \,$, the largest structure percolates and is much more massive than other objects. It may be considered as defining the cosmic web. For a threshold of $5\left \langle \rho \right \rangle \,$, it contains about half of all cosmic mass and occupies $\sim 1{{\ \rm per\ cent}}$ of all cosmic volume; a typical external point is then ∼7h−1 Mpc from the web. We investigate the internal structure and clustering of tlt peaks. Defining the saddle point density ρlim  as the density at which a peak joins its parent peak, we show the median value of ρlim  for FoF-like peaks to be similar to the density threshold at percolation. Assembly bias as a function of ρlim  is stronger than for any known internal halo property. For peaks of group mass and below, the lowest quintile in ρlim  has b ≈ 0, and is thus uncorrelated with the mass distribution.
Towards a complete description of spectra and polarization of black hole accretion discs: albedo profiles and returning radiation
Authors: Taverna R , Zhang W , Dovčiak M , Bianchi S , Bursa M , Karas V , Matt G 
Published: February 2020

ABSTRACT
Accretion discs around stellarmass black holes (BHs) emit radiation peaking in the soft X-rays when the source is in the thermal state. The emerging photons are polarized and, for symmetry reasons, the polarization integrated over the source is expected to be either parallel or perpendicular to the (projected) disc symmetry axis, because of electron scattering in the disc. However, due to general relativity effects photon polarization vectors will rotate with respect to their original orientation, by an amount depending on both the BH spin and the observer’s inclination. Hence, X-ray polarization measurements may provide important information about strong gravity effects around these sources. Along with the spectral and polarization properties of radiation which reaches directly the observer once emitted from the disc, in this paper we also include the contribution of returning radiation, i.e. photons that are bent by the strong BH gravity to return again on the disc, where they scatter until eventually escaping to infinity. A comparison between our results and those obtained in previous works by different authors shows an overall good agreement, despite the use of different code architectures. We finally consider the effects of absorption in the disc material by including more realistic albedo profiles for the disc surface. Our findings in this respect show that considering also the ionization state of the disc may deeply modify the behaviour of polarization observables.
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
Authors: Norvil Allison B , AlAbdi Lama , Liu Bigang , Tu Yu Han , Forstoffer Nicole E , Michie Amie R , Chen Taiping , Gowher Humaira 
Published: February 2020

Abstract
We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect of Arg882His in DNMT3A is not fully understood. Here, we discovered that DNMT3A WT enzyme under conditions that favor non-cooperative kinetic mechanism as well as DNMT3A Arg882His variant acquire CpG flanking sequence preference akin to that of DNMT3B, which is non-cooperative. We tested if DNMT3A Arg882His could preferably methylate DNMT3B-specific target sites in vivo. Rescue experiments in Dnmt3a/3b double knockout mouse embryonic stem cells show that the corresponding Arg878His mutation in mouse DNMT3A severely impairs its ability to methylate major satellite DNA, a DNMT3A-preferred target, but has no overt effect on the ability to methylate minor satellite DNA, a DNMT3B-preferred target. We also observed a previously unappreciated CpG flanking sequence bias in major and minor satellite repeats that is consistent with DNMT3A and DNMT3B specificity suggesting that DNA methylation patterns are guided by the sequence preference of these enzymes. We speculate that aberrant methylation of DNMT3B target sites could contribute to the oncogenic potential of DNMT3A AML variant.
Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis
Authors: Lamoth Frederic , Clancy Cornelius J , Tissot Frederic , Squires Kevin , Eggimann Philippe , Flückiger Ursula , Siegemund Martin , Orasch Christina , Zimmerli Stefan , Calandra Thierry , Marchetti Oscar , Nguyen Minh H , Bochud Pierre-Yves 
Published: February 2020

AbstractPerformance of T2Candida for detecting intra-abdominal candidiasis (IAC) was assessed in 48 high-risk patients. T2Candida sensitivity/specificity and positive/negative predictive values were 33%/93% and 71%/74%, respectively. IAC was present in 100% of cases with concordant positive T2Candida/1,3-beta-d-glucan and absent in 90% of concordant negative results. Combination T2Candida/1,3-beta-d-glucan may help guide treatment decisions.
Chemical Evolution of Calc-alkaline Magmas during the Ascent through Continental Crust: Constraints from Methana, Aegean Arc
Authors: Schoenhofen Milena V , Haase Karsten M , Beier Christoph , Woelki Dominic , Regelous Marcel 
Published: February 2020

AbstractQuaternary calc-alkaline andesitic to dacitic lavas effusively erupted on top of about 30 km thick accreted continental crust at Methana peninsula in the western Aegean arc. We present new data of major and trace element concentrations as well as of Sr–Nd–Pb isotope ratios along with mineral compositions of Methana lavas and their mafic enclaves. The enclaves imply a parental basaltic magma and fractional crystallization processes with relatively little crustal assimilation in the deep part of the Methana magma system. The composition of amphibole in some mafic enclaves and lavas indicates deeper crystallization at ∼25 km depth close to the Moho compared with the evolved lavas that formed at &lt;15 km depth. The presence of amphibole and low Ca contents in olivine suggest high water contents of ∼4 wt% in the primitive magmas at Methana. The compositions of andesitic and dacitic lavas reflect fractional crystallization, assimilation of sedimentary material, and magma mixing in the upper 15 km of the crust. The Methana magmas have fO2 of FMQ + 1 to FMQ + 2 (where FMQ is the fayalite–magnetite–quartz buffer) at temperatures of 1200 to 750 °C and the fO2 does not vary systematically from mafic to felsic compositions, suggesting that the mantle wedge was oxidized by sediment subduction. Amphibole is an important fractionating phase in the more evolved Methana magmas and causes significant changes in incompatible element ratios. Although xenocrysts and mineral compositions indicate magma mixing, the major and trace element variation implies only limited mixing between dacitic and basaltic melts.
Proportions of B-cell subsets are altered in incomplete systemic lupus erythematosus and correlate with interferon score and IgG levels
Authors: Henning Svenja , Lambers Wietske M , Doornbos-van der Meer Berber , Abdulahad Wayel H , Kroese Frans G M , Bootsma Hendrika , Westra Johanna , de Leeuw Karina 
Published: February 2020

Abstract

Objectives
Incomplete SLE (iSLE) patients display symptoms typical for SLE but have insufficient criteria to fulfil the diagnosis. Biomarkers are needed to identify iSLE patients that will progress to SLE. IFN type I activation, B-cell-activating factor (BAFF) and B-cell subset distortions play an important role in the pathogenesis of SLE. The aim of this cross-sectional study was to investigate whether B-cell subsets are altered in iSLE patients, and whether these alterations correlate with IFN scores and BAFF levels.

Methods
iSLE patients (n = 34), SLE patients (n = 41) with quiescent disease (SLEDAI ≤4) and healthy controls (n = 22) were included. Proportions of B-cell subsets were measured with flow cytometry, IFN scores with RT-PCR and BAFF levels with ELISA.

Results
Proportions of age-associated B-cells were elevated in iSLE patients compared with healthy controls and correlated with IgG levels. In iSLE patients, IFN scores and BAFF levels were significantly increased compared with healthy controls. Also, IFN scores correlated with proportions of switched memory B-cells, plasma cells and IgG levels, and correlated negatively with complement levels in iSLE patients.

Conclusion
In this cross-sectional study, distortions in B-cell subsets were observed in iSLE patients and were correlated with IFN scores and IgG levels. Since these factors play an important role in the pathogenesis of SLE, iSLE patients with these distortions, high IFN scores, and high levels of IgG and BAFF may be at risk for progression to SLE.