bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Knee- and Hip-Extensor Strength and Running-Related Injury Biomechanics in Collegiate Distance Runners
Authors: Moffit Tyler J. , Montgomery Melissa M. , Lockie Robert G. , Pamukoff Derek N. 
Published: November 2020

Context
Running-related injuries are common in distance runners. Strength training is used for performance enhancement and injury prevention. However, the association between maximal strength and distance-running biomechanics is unclear.

Objective
To determine the relationship between maximal knee- and hip-extensor strength and running biomechanics previously associated with injury risk.

Design
Cross-sectional study.

Setting
Research laboratory.

Patients or Other Participants
A total of 36 collegiate distance runners (26 men, 10 women; age = 20.0 ± 1.5 years, height = 1.74 ± 0.09 m, mass = 61.97 ± 8.26 kg).

Main Outcome Measure(s)
Strength was assessed using the 1-repetition maximum (1RM) back squat and maximal voluntary isometric contractions of the knee extensors and hip extensors. Three-dimensional running biomechanics were assessed overground at a self-selected speed. Running variables were the peak instantaneous vertical loading rate; peak forward trunk-lean angle; knee-flexion, internal-rotation, and -abduction angles and internal moments; and hip-extension, internal-rotation, and -adduction angles and internal moments. Separate stepwise linear regression models were used to examine the associations between strength and biomechanical outcomes (ΔR2) after accounting for sex, running speed, and foot-strike index.

Results
Greater 1RM back-squat strength was associated with a larger peak knee-flexion angle (ΔR2 = 0.110, ΔP = .045) and smaller peak knee internal-rotation angle (ΔR2 = 0.127, ΔP = .03) and internal-rotation moment (ΔR2 = 0.129, ΔP = .03) after accounting for sex, speed, and foot-strike index. No associations were found between 1RM back-squat strength and vertical loading rate, trunk lean, or hip kinematics and kinetics. Hip- and knee-extensor maximal voluntary isometric contractions were also not associated with any biomechanical variables.

Conclusions
Greater 1RM back-squat strength was weakly associated with a larger peak knee-flexion angle and smaller knee internal-rotation angle and moment in collegiate distance runners. Runners who are weaker in the back-squat exercise may exhibit running biomechanics associated with the development of knee-related injuries.
Fore-Stomach Foreign Bodies: prevalence, associated risk factors and types affecting cattle slaughtered at Gondar ELFORA abattoir, northwest Ethiopia
Authors: Bihon Amare , Bayeleyegn Teketaye , Assefa Ayalew , Muktar Yimer 
Published: November 2020

In Ethiopia, recurrent drought and feed shortage coupling with high level of environmental pollution predispose the animals to foreign body ingestion. A cross-sectional study with systematic random sampling approach was employed from November 2018 to April, 2019 with the objectives of estimating the prevalence; identify associated risk factors and to categorize the types of foreign body in cattle slaughtered at Gondar ELFORA Abattoir. Ante-mortem and postmortem examinations were used to collect the data. From the total of 384 animals examined, the overall prevalence of foreign body was 83(21.61%). Adult and old animals were 4.33 (95% CI=0.98, 19.00, p=0.052) and 4.54 (95% CI=1.03, 19.96, p=0.045) times more likely to have a chance of getting foreign body than young animals by keeping another factors constant, respectively. However, the difference is not statistically significant for adult cattle. Moreover, poor and medium body conditioned animals were 2.19 (95% CI=1.04, 4.56, p=0.037) and 1.51 (95% CI=0.72, 3.13, p=0.273) times more likely to acquire foreign bodies than good body conditioned animals by keeping another factors constant. In the positive cases (N=83), 41(49.40%), 34(40.96%), 8(9.64%) and 0(0%) of the foreign bodies were found in the rumen, reticulum, both rumen and reticulum, and omasum, respectively. Majority of foreign bodies identified (79.51%) were non-metallic in nature, including clothes, plastics, rope, sand and stone. Designing and implementation of appropriate solid waste disposal and management practices are strongly recommended to reduce the risk of ingestion of indigestible foreign bodies.
Keyword: Abattoir; Cattle; Foreign body; Fore stomach; Prevalence
Effects of icariin and quercetin on high glucose-induced neuronal cell apoptosis
Authors: Dong Mengqian , Jin Ying , Huang Peifen , Chen Zhiyang 
Published: November 2020

Purpose: To study the effects of icariin and quercetin on cell apoptotic changes in neurons induced by elevated glucose condition, and the mechanism involved.
Methods: Neonatal male Sprague Dawley rats (n = 48) weighing 5 – 7 g were used. Neuronal cells were isolated from rat hippocampus and cultured after purification. The cells were randomly assigned to six groups: control, high glucose, icariin, quercetin, serine/threonine-specific protein kinase (Akt) inhibitor, and Akt agonist groups. The Akt inhibitor and agonist used in this study were MK-22062hci and SC79, respectively. The influence of icariin and quercetin on neuronal apoptotic changes were determined flow cytometrically, while their effects on levels of expression of Akt, p-Akt, bax and bcl-2 were determined with Western blotting.
Results: Treatment with icariin or quercetin significantly inhibited apoptosis induced by high glucose. The concentrations of Akt, p-Akt, and bcl-2 proteins were markedly upregulated in high glucose group, relative to control (p < 0.05). The corresponding expression of bax was significantly down-regulated in high glucose group, relative to control (p < 0.05). Treatment with icariin or quercetin, or their agonists reversed high glucose-mediated alterations in these protein levels (p < 0.05).
Conclusion: Icariin and quercetin inhibit neuronal cell apoptosis induced by high glucose through upregulation of bcl-2 expression and down- regulations of bax expression and Akt-induced protein phosphorylation. Thus, Icariin and quercetin possess potential benefits for the treatment of neurological diseases.
Keywords: Apoptosis, High glucose condition, Hippocampal neurons, Icariin, Quercetin
Effect of anti-CIRP antibody on inflammatory response, tumor formation and abdominal aortic aneurysm in rats
Authors: Wang Yuqing , Lu Lantao , Li Weiyan , Gu Shuntong 
Published: November 2020

Purpose: To investigate the effect of anti-cold induced RNA binding protein (CIRP) antibody on inflammation, tumor formation and abdominal aortic aneurysm in rats.Methods: Thirty healthy male Wistar rats were assigned to pseudo-operation, abdominal aortic aneurysm model, and anti-CIRP groups, with 10 in each group. The levels of CIRP, TNF- α, monocyte giant cytokine chemokine-1 (MCP-1), Toll-like receptor 4 (TLR4)) and nuclear factor kappaB (NF- κB)were determined compared among the groups.Results: At both 2 and 4 weeks, the expression of CIRP protein in the model group was significantly higher than that in the sham operation group (p < 0.05). At these two time-points, tumor formation and maximum diameter were higher in anti-CIRP and model control rats than in pseudo-operation rats. After 4 weeks of treatment, the protein expressions of TNF- α, MCP-1, TLR4 and NF-κB were higher in anti-CIRP and model control rats than in pseudo-operation rats, but were lower than model control values (p < 0.05).Conclusion: CIRP expression is significantly increased in abdominal aortic aneurysm tissue and serum, and is involved in the onset and progress of abdominal aortic aneurysm. Anti-CIRP antibody therapy effectively suppresses tumorigenesis, and inhibits tumor wall inflammatory reaction viaTLR4/NF-κB pathway. This finding provides a clue and new strategy for the clinical management of abdominal aortic aneurysm.
Keywords: CIRP, Abdominal aortic tumor wall, Inflammatory reaction, Protein expression, Tumor body
Synergistic hypolipidemic and hypoglycemic effects of mixtures of Lactobacillus nagelii/betanin in a mouse model
Authors: Rivera Antonio , Becerra-Martinez Elvia , Pacheco-Hernández Yesenia , Landeta-Cortés Gerardo , Villa-Ruano Nemesio 
Published: November 2020

Purpose: To determine the nutraceutical effect of mixtures containing Lactobacillus nagelii/betanin on the carbohydrate and lipid metabolism of mice.Methods: Lactobacillus nagelii and betanin were isolated from the raw materials. These components were subsequently assessed for their anti-hyperglycemic and hypolipidemic activities, and administered individually or combined in normoglycemic and diabetic mice. These animals were subjected to a standard OGTT and given an atherogenic diet.Results: The combination of L. nagelii (2.0 × 109 CFU/mL) and betanin (30 mg/kg body weight) exerted a significant (p < 0.01) and prolonged reduction of postprandial blood glucose (30 - 120 min). Interestingly, a mixture of L. nagelii (1 ×107 CFU/mouse/day) with betanin (10 mg/kg body weight) administered for 30 days, produced favourable effects (p < 0.01) in the lipid profile of mice previously treated with an atherogenic diet. These mixtures significantly ameliorated (p < 0.01) hypoinsulinemia, hyperleptinemia and increased the levels of adiponectin.Conclusion: The simultaneous administration of L. nagelii and betanin in mice produced a beneficial change in blood glucose and lipids in mice, indicating a synergistic nutraceutical effect. However, there is a need to develop this therapy further for potential application in humans
Keywords: Lactobacillus nagelii, Betanin, Anti-hyperglycemic, Hypolipidemic
Targeting of protein expression in renal disease using siRNA – A review
Authors: Buabeid Manal Ali , Ibrahim Nihal Abdalla , Kharaba Zelal Jaber , Umar Muhammad Ihtisham , Murtaza Ghulam 
Published: November 2020

The kidneys have rarely been used as a target in the systemic delivery of siRNA when compared to other tissues or organs in the body. This review article deals with various modalities adopted to deliver siRNA to the renal system under different normal and pathophysiological states. In this article, the authors have reviewed extensive clinical data that describe the use of siRNA for the treatment of renal diseases. Conventional and 3D modeling utilizes the existing genome-based RNA libraries, which facilitated the identification of molecular pathways involved in renal diseases.
Keywords: siRNA, kidney disease, targeting proteins, signal pathways
Prognostic potential of CK-19 managing disseminated oral squamous cell carcinomas in Pakistan: A descriptive cross-sectional study
Authors: Waqas Iqbal  , Uzma Tariq  , Arhama Surwaich  , Surwaich Ali channa  , Abdul Majid  , Shan Ali  , Naeem Bukhari  , Admin  
Published: November 2020

Abstract
A cross-sectional study was conducted to assess the adoptability of CK-19 as a routine diagnostic assay and potential prognostic marker following disseminated oral squamous cell carcinoma in Pakistani population.
The current descriptive study was conducted at Isra Dental College Hospital, Isra University, Hyderabad, Pakistan. Suspected patients of oral squamous cell carcinomas (OSCC), who visited the Isra Dental College Hospital’s outpatient department from January 2014 up to January 2015 with four year follow up (from January 2015 up to December 2019), were included after ethical approval of the Institutional board. SPSS version 21.0 was used for data analysis.
Sixty cases of oral squamous cell carcinoma (OSCC) were selected for CK-19 quantification by using PCR before and after incisional biopsy.
DIAGNOSTIC AND REHABILITATION OPPORTUNITIES OF DUAL-TASKS FOR BRAIN TRAUMA
Authors: Zhavoronkova Ludmila Alexeevna , Maksakova Olga Arsen’evna , Кushnir Elena Mikhailovna , Skorjatina Irina Gennadievna 
Published: November 2020

Complex clinical, EEG and stabilographic examination revealed predominantly cognitive deficit in patients
with moderate traumatic injury (mTBI) while dual tasks were performed. The EEG data demonstrated a decrease
in the coherence for slow (delta-theta) rhythms in the frontal-temporal areas predominantly of the left
hemisphere during cognitive tasks performance in patients. In healthy subjects an increase of EEG coherence
for slow spectral bands was observed in these brain areas by contrast. An increase of EEG coherence
was obtained for fast spectral bands - alpha2 and beta, predominantly at the right hemisphere while the motor
components of the dual tasks were performed in healthy adults and patients. Rehabilitation course involving
the use of dual-tasking contributed to a predominant reduction in cognitive deficits and an increase
of EEG coherence at the frontal-temporal areas of the left hemisphere. So, dual-tasks may be used as diagnostic
tool in patients after mTBI. Pilot studies allowed the proposed also rehabilitation effect of dualtasking
in mTBI patients with primary and predominant restoration of cognitive functions and recovery of
EEG coherence for slow spectral bands after rehabilitation course. So, our data allowed to propose that dual-tasks may be used as diagnostic as well rehabilitation tool in patients after mTB with the most sensitivity of the left hemisphere to traumatic effect and rehabilitation procedures.
POLYMORPHISM OF ANTIOXIDANT DEFENSE GENES AND LIFESPAN
Authors: Erdman Vera Viktorovna , Nasibullin Timur Ruslanovich , Tuktarova Ilsiar Avkhatovna , Timasheva Yanina Rimovna , Danilko Ksenia Vladimirovna , Matua Alisa Zaurovna , Viktorova Tatiana Viktorovna 
Published: November 2020

In the ethnic group of Russians, residents of the Republic of Bashkortostan, age-dependent changes in the
alleles and genotypes frequencies in SOD1, SOD2, PON1, PON2, NQO1, GPX1 genes SNVs were found. Enzymes, encoded by these genes, are involved in the metabolism of reactive oxygen species of the first and second stages, as well as toxic compounds of endogenous and exogenous nature.
AUTOIMMUNE RESPONSE OF GLUTAMATE RECEPTORS AND NITRIC OXIDE IN EPILEPSY AND TRAUMATIC BRAIN INJURY
Authors: Sorokina Elena Gennad’evna , Semenova Zhanna B. , Globa Oksana V. , Karaseva Olga V. , Reutov Valentin P. , Ignatieva Galina A. , Afanasieva Sofya A. , Ovcharenko Dmitry S. , Khunteev German A. , Roshal Leonid M. , Pinelis Vsevolod G. 
Published: November 2020

In children with epilepsy and traumatic brain injury (TBI), the content of autoantibodies (aAb) to glutamate
receptors (NMDA and AMPA subtypes) and the level of nitric oxide products - nitrothyrosine (NT) and nitrates/
nitrites (NOx) in the blood were studied. The obtained data make it possible to reveal the specificity of
damage to AMPA and NMDA subtypes of glutamate receptors in convulsive states and posttraumatic brain
injuries. The participation of NO and its products in the development of autoimmune response was revealed.
ADOPTION OF SUPPLY CHAIN DRIVERS ON SUSTAINABLE PERFORMANCE OF CONSTITUENCY DEVELOPMENT FUNDED PROJECTS IN THE COUNTY GOVERNMENT OF BUNGOMA
Authors: Hussein Wamalwa Moses , Musau Enock Gideon 
Published: November 2020

Purpose: The focus of the study was to analyze the influence of supply chain drivers on performance of National Government Constituency Development funded projects in Bungoma County.
Methodology: Based on pragmatic worldview the study employed descriptive research design. The target population of the study consisted of five prequalified accredited service providers’ contractors in Bungoma County with a total composition of 293 staff from which a sample size of 169 was drawn from the entire population.The data collection tool was the questionnaire which was subjected to pre testing through piloting before actual data collection. The data was analyzed descriptively and inferentially with the aid of SPSS tool and presented by use of tables. Correlation analysis was performed to establish the relationship between variables and multiple regressions to determine the cause effect of the variables.
Findings: Result of multiple regressions revealed that supply chain drivers jointly and independently influence performance of NGCDF funded projects in Bungoma County, Kenya. The study findings showed that all study variables (ICT β=0.136, p<0.05, material management β=0.140, p<0.05, supplier selection β=0.317, p<0.05 and contract β=0.280, p<0.05 were significant to performance of NGCDF funded projects in Bungoma county. Therefore the study concluded that supply chain practices of ICT, material flow, supplier selection and contractual capacity affects the performance of funded projects.
Unique contribution to theory, practice and policy: The study recommends that the county government management in Kenya need to invest in constant training of their employees on effective supply chain practices to enhance their performance and appropriate measures put in place that ensure that potential risks regarding contract management and detected in advance and mitigated to enhance operational performance.
The frontiers of acute stroke management
Authors:   Royal Melbourne Hospital, Park Ashley , Campbell Bruce ,   Royal Melbourne Hospital
Published: November 2020

The field of stroke has rapidly advanced in recent years with more effective reperfusion therapies (thrombolysis and endovascular thrombectomy) applied to a broader range of patients, including using imaging-based selection to treat beyond standard time windows. Recent trials have provided signals that neuroprotection and specific treatments for intracerebral haemorrhage may be achievable. The range of targeted secondary prevention strategies has also expanded, particularly with direct oral anticoagulants, more potent lipid lowering agents and patent foramen ovale closure.
ANALISIS EMPIRIS INKLUSIFITAS KEUANGAN SYARIAH DI INDONESIA
Authors: Azwar Azwar Azwar 
Published: November 2020

Penelitian ini bertujuan untuk mengukur dan menganalisis inklusifitas keuangan syariah pada 33 provinsi di Indonesia. Dengan menggunakan data sekunder berbasis tahunan dari publikasi Bank Indonesia dan Badan Pusat Statistik, penelitian ini mengestimasi inklusifitas keuangan syariah di Indonesia dengan metode Index for Syariah Financial Inclusion (ISFI) yang dikembangkan dari Sarma (2012) berdasarkan tiga dimensi pengukuran yaitu accessibility, availability dan usage of banking services. Penelitian ini secara empiris membuktikan bahwa indeks inklusifitas keuangan syariah di Indonesia secara umum tergolong rendah yaitu dengan average value sebesar 0,127. Pada tingkat provinsi, ditemukan bahwa Provinsi Bangka Belitung memiliki indeks inklusifitas tertinggi dibandingkan provinsi lainnya di Indonesia. Temuan ini bermakna bahwa kelompok masyarakat tidak sepenuhnya menggunakan jasa keuangan formal, khususnya, sebagai sumber keuangan dan pembiayaan utama, sehingga pengambil kebijakan perlu untuk meningkatkan availabilitas keuangan syariah dengan menambah dan memperluas layanan perbankan syariah di Indonesai khususnya pada Kawasan Timur Indonesia. Lebih lanjut, penelitian ini juga menganalisis hubungan antara inklusifitas keuangan syariah dan kesejahteraan masyarakat. Melalui metode Product Moment Coefficient of Correlation, penelitian ini menemukan adanya korelasi positif dan signifikan antara inklusiftas keuangan syariah dan kesejahteraan masyarakat di Indonesia. Umumnya, provinsi dengan Human Devepelment Index (HDI) yang tinggi dan medium dapat dianalogikan relatif memiliki inklusi keuangan yang tinggi pula.
ECONOMIC GROWTH AND CO2 EMISSIONS IN INDONESIA : INVESTIGATING THE ENVIRONMENTAL KUZNETS CURVE HYPOTHESIS EXISTENCE
Authors: Iskandar Azwar 
Published: November 2020

Peningkatan ancaman polusi udara dan pemanasan global telah dibahas secara luas dalam berbagai event internasional. Environmental Kuznets Curve (EKC) menjadi sebuah isu riset yang memotivasi banyak studi dalam mengklaim adanya hubungan antara pendapatan ekonomi dan emisi CO2 melalui pembuktian hipotesis inverted U-shaped, dimana hipotesis ini menjelaskan bahwa pada tahap awal pertumbuhan ekonomi, degragdasi lingkungan akan terjadi, tetapi pada tahap puncak pertumbuhannya justru akan mengurangi emisi CO2 bagi lingkungan. Penelitian ini bertujuan untuk menguji keberadaan Environmental Kuznets Curve (EKC) Hypothesis dalam hubungan antara pertumbuhan ekonomi dan emisi karbondioksida di Indonesia selama periode tahun 194-2016. Penelitian ini menggunakan teknik analisis Autoregressive Distributed Lag (ARDL) co-integration. Data yang digunakan merupakan data sekunder yang berasal dari World Bank Development Indicators. Hasil penelitian mengindikasikan bahwa hipotesis EKC tidak terdapat di Indonesia. Selain itu, permodelan jangka panjang menunjukkan bahwa pertumbuhan ekonomi khususnya pada sektor electricity and heat production memberikan dampak positif dan signifikan terhadap emisi karbondioksida di Indonesia. Atas dasar temuan-temuan tersebut, penelitian ini mengisyaratkan adanya kebutuhan mendesak bagi Indonesia untuk menekankan perluasan service intensive economy daripada resource intensive, serta pengembangan sumber-sumber energi terbarukan dalam rangka memitigasi degradasi lingkungan seiring perkembangan dan pertumbuhan ekonomi.
The increasing threat of air pollution and global warming has been widely discussed in various international events. Environmental Kuznets Curve (EKC) become an independent research issue and motivated a bulky number of studies that claims an inverted U-shaped relationship between income and CO2 emission : at early stage of development, environmental degradation occurs, but at certain point the increase in economic development will decrease CO2 emission. This study aims to investigate the existing of EKC hypothesis and the dynamic relationship between CO2 emission and economic growth and in Indonesia case the period 1981-2016 using Autoregressive Distributed Lag (ARDL) co-integration framework. Data were retrieved from World Bank Development Indicators. The findings reveal that EKC Hypothesis does not exist. In addition, the long run model show that economy growth appear to have significant positive impact on CO2 emission especially from electricity and heat production. These findings suggest a dire need for Indonesia to shift towards service intensive economy rather than resource intensive, and alternative renewable energy sources in order to mitigate environmental degradation as well as promote economic development.