bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prototyping public friction: Exploring the political effects of design testing in urban space
Authors: Tironi Martín 
Published: December 2019

AbstractThe use of prototypes as testing instruments has become a common strategy in the innovation of services and products and increasingly in the implementation of “smart” urban policies through living labs or pilots. As a technique for validating hypotheses about the future performance of products or policies, prototyping is based on the idea of generating original knowledge through the failures produced during the testing process. Through the study of an experimentation and prototyping project developed in Santiago de Chile called “Shared Streets for a Low‐Carbon District,” I analyse the technique of prototyping as a political device that can make visible (or invisible) certain entities and issues, determining what the experimental entities can do and say. I will show how the technique of prototyping defines modes of participation, what is visible and thinkable, what can be spoken and what is unspeakable. In this sense, I examine two ambivalent capacities of prototyping: as a mechanism of management and enrolment that seeks to prescribe normativities (problem‐validating prototype) and as an event that can make frictions tangible, articulating matters of concern and ways to open up alternative scenarios (problem‐making prototype).
Advance directives of lung cancer patients and caregivers in China: A cross sectional survey
Authors: Feng Chenchen , Wu Juan , Li Junying , Deng Han Yu , Liu Jiewei , Zhao Shuzhen 
Published: December 2019

AbstractBackgroundThis study aimed to investigate lung cancer patients and attitudes of their caregivers toward advance directives (ADs) in China.MethodsA cross sectional study was conducted in the Department of Oncology outpatient clinic in West China Hospital, Sichuan University. A questionnaire was used to survey the attitudes of lung cancer patients and caregivers toward ADs.ResultsA total of 148 lung cancer patients and 149 caregivers were enrolled into the study. Of these, 94.6% and 89.9% of patients and caregivers had not heard of AD and none of those in the study had ever signed an AD. A total of 79.7% patients and 75.2% caregivers were willing to sign ADs after they were provided with information. Patients who preferred the end of life period to sign ADs were 5.4 times more likely to have ADs than patients who chose to sign ADs when their disease was diagnosed (P < 0.05, 95%CI [1.27–22.93]). Caregivers who were reluctant to undergo chemotherapy when diagnosed with cancer were 2.16 times more likely to sign ADs than those willing to receive chemotherapy (P < 0.05, 95%CI [1.20–3.90]).ConclusionsIn China, lung cancer patients and their caregivers showed lack of knowledge about ADs, and the completion rate of ADs was extremely low. However, participants were positive about ADs and public education on ADs may help to increase the completion rate of ADs in China.
Phase II study of ramucirumab and docetaxel for previously treated non‐small cell lung cancer patients with malignant pleural effusion: Protocol of PLEURAM study
Authors: Takemoto Shinnosuke , Fukuda Minoru , Yamaguchi Hiroyuki , Ikeda Takaya , Akagi Kazumasa , Tomono Hiromi , Umeyama Yasuhiro , Dotsu Yosuke , Taniguchi Hirokazu , Gyotoku Hiroshi , Senju Hiroaki , Kitazaki Takeshi , Nakatomi Katsumi , Nagashima Seiji , Fukuda Masaaki , Kinoshita Akitoshi , Soda Hiroshi , Mukae Hiroshi 
Published: December 2019

IntroductionAnti‐vascular endothelial growth factor therapy has been shown to be effective in non‐small cell lung cancer (NSCLC) patients with malignant pleural effusion (MPE); however, there are no data to suggest that ramucirumab has the same effects.MethodsWe therefore decided to conduct a phase II study of ramucirumab plus docetaxel for NSCLC patients with MPE. The MPE control rate at eight weeks after the start of treatment will be the primary endpoint, and the objective response rate, progression‐free survival, one‐year survival rate, overall survival, and toxicity profile will be secondary endpoints.DiscussionA previous study indicated that administering chemotherapy in combination with bevacizumab was effective at controlling pleural effusion in patients with NSCLC with carcinomatous pleurisy. It is expected that ramucirumab will have a similar effect to the same group.
Prolonged quiescence delays somatic stem cell‐like divisions in Caenorhabditis elegans and is controlled by insulin signaling
Authors: Olmedo María , Mata‐Cabana Alejandro , Rodríguez‐Palero María Jesús , García‐Sánchez Sabas , Fernández‐Yañez Antonio , Merrow Martha , Artal‐Sanz Marta 
Published: December 2019

AbstractCells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.
Editorial: the emergence of non‐hypervascular hypointense nodules on Gd‐EOB‐DTPA‐enhanced MRI in patients with chronic hepatitis C
Authors: Crane Harry G. , Davison Scott A. , Levy Miriam T. 
Published: December 2019

LINKED CONTENTThis article is linked to Toyoda et al papers. To view these articles, visit https://doi.org/10.1111/apt.15490 and https://doi.org/10.1111/apt.15546.
Editorial: rapid disease progression in hepatitis delta—can we turn the tide? Authors' reply
Authors: Palom Adriana , Riveiro‐Barciela Mar , Buti Maria ,   all authors
Published: December 2019

LINKED CONTENTThis article is linked to Palom et al and Sonneveld and de Knegt papers. To view these articles, visit https://doi.org/10.1111/apt.15521 and https://doi.org/10.1111/apt.15549.
Letter: should we intensify infliximab in acute severe ulcerative colitis? Author's reply
Authors: Sebastian Shaji 
Published: December 2019

LINKED CONTENTThis article is linked to Sebastian et al and Laharie and Rivière papers. To view these articles, visit https://doi.org/10.1111/apt.15456 and https://doi.org/10.1111/apt.15520.
Letter: is measurement of faecal biomarkers helpful for the early diagnosis and prediction of pouchitis after proctocolectomy for ulcerative colitis? Authors' reply
Authors: Kayal Maia , Ungaro Ryan 
Published: December 2019

LINKED CONTENTThis article is linked to Kayal et al and Yamamoto et al papers. To view these articles, visit https://doi.org/10.1111/apt.15505 and https://doi.org/10.1111/apt.15566.
Performance management of public–private collaboration in innovation
Authors: Cheah Sarah Lai‐Yin , Yoneyama Shigemi , Ho Yuen‐Ping 
Published: December 2019

AbstractThe open innovation literature has highlighted that more focus should be placed on non‐pecuniary sources such as public research institutes (PRIs) and their performance management (PM), while innovation network studies have highlighted the growing importance of universities and PRIs in public‐private research partnerships. Building on PM capability and portfolio management perspectives, this research aims is to examine the relationship between knowledge resources and collaboration outcome in such public‐private collaborations, and the mediating role of senior management team's (SMT) ability to govern project portfolio approval and management processes. Examining 153 innovation commercialization collaboration projects between PRIs and firms in Singapore, our study has made several significant contributions to the existing research on innovation and performance in public‐private partnership. First, we empirically demonstrate that there is a direct positive relationship between PRIs' knowledge resources and collaboration outcome. Second, our findings establish that the PRIs' SMT ability to govern project portfolio processes mediates this positive relationship. Third, this research highlights that the SMT ability to govern project portfolio processes fully mediates the conversion of market knowledge into innovation. Only partial mediation is observed in the case of technological knowledge, which directly creates value by virtue of generating discoveries or breakthroughs.
Histopathologic findings characteristic of CARD14‐associated papulosquamous eruption
Authors: Ring Nan G. , Craiglow Brittany G. , Panse Gauri , Antaya Richard J. , Ashack Kurt , Ashack Richard , Faith Esteban F. , Paller Amy S. , McNiff Jennifer M. , Choate Keith A. , Ko Christine J. 
Published: December 2019

AbstractBackgroundPathogenic mutations in caspase recruitment domain‐containing protein 14 (CARD14) lead to CARD14‐associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14‐associated papulosquamous eruption.MethodsThis retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14‐associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris.ResultsLesional skin biopsies from patients with CARD14‐associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging.ConclusionCARD14‐associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.
Medical and surgical management of obesity and diabetes: what's new?
Authors: Ammori B. J. , Skarulis M. C. , Soran H. , Syed A. A. , Eledrisi M. , Malik R. A. 
Published: December 2019

AbstractWe conducted a narrative review of the medical and surgical management of people with obesity and diabetes. Results of this review showed that a 5–10% loss in body weight can be achieved with a change in lifestyle, diet and behaviour and with approved pharmacological therapies in people with obesity and diabetes. New targeted therapies are now available for patients with previously untreatable genetic causes of obesity. Compared to medical treatment, metabolic and bariatric surgery is associated with significantly higher rates of remission from type 2 diabetes and lower rates of incident macrovascular and microvascular complications and mortality. The National Institute for Health and Care Excellence and the American Diabetes Association endorse metabolic and bariatric surgery in obese adults with type 2 diabetes and there may also be a role for this in obese individuals with type 1 diabetes. The paediatric committee of the American Society for Metabolic and Bariatric Surgery have recommended metabolic and bariatric surgery in obese adolescents with type 2 diabetes. Earlier and more aggressive treatment with metabolic and bariatric surgery in obese or overweight people with diabetes can improve morbidity and mortality.
Early left atrial dysfunction is associated with suboptimal cardiovascular health
Authors: Ocaranza María Paz , Bambs Claudia , Salinas Manuel , Matamala Cristian , Garcia Lorena , Troncoso Rodrigo , Pedrozo Zully , Huidobro Andrea , Venegas Pia , Paredes Fabio , Giacaman Arturo , Zalaquett Ricardo , Chiong Mario , Verdejo Hugo E. , Ferreccio Catterina , Lavandero Sergio , Castro Pablo F. , Gabrielli Luigi 
Published: December 2019

AbstractAimsTwo‐dimensional speckle‐tracking echocardiography can assess left atrial (LA) function by measuring atrial volumes and deformation parameters (strain, strain rate). This cross‐sectional analysis explores the association between ideal CV health (CVH), LA function, and systemic biomarkers in healthy individuals from the Chilean MAUCO Cohort.MethodsWe enrolled 95 MAUCO participants with different levels of CVH (mean age: 51 ± 8 years). We categorized participants into low or high CVH groups: A: 0‐2, or B: 3‐6 CVH risk factors. 2D echocardiography, glucose, insulin, total cholesterol, triglycerides, proBNP, hsCRP, insulin resistance index (HOMA), and right and left atrial strain (RASs and LASs, respectively) were determined.ResultsLASs was lower in Group A, while systolic and diastolic blood pressure (BP), body mass index (BMI), insulin, HOMA, total cholesterol, triglycerides, and LV and RV end‐diastolic volume were significantly higher in Group A than Group B (P < .01). Change in LASs was inversely correlated with insulin (P = .040), HOMA (P = .013), total cholesterol (P = .039), glycemia (P = .018), and BMI (P = .0.037).ConclusionLASs during the reservoir phase was diminished in subjects with a lower level of CVH. Higher insulin, HOMA, total cholesterol, glycemia, and BMI values were associated with decreased LA deformation during the reservoir phase. Morphofunctional alterations of the LA were also identified in the group with suboptimal CVH, as well as BP values in the range of hypertension. LA dysfunction in an asymptomatic population, along with metabolic syndrome, could be an early event in the continuum of CV damage.
Components of Legal Concepts: Quality of Law, Evaluative Judgement, and Metaphorical Framing of Article 8 ECHR
Authors: Slosser Jacob Livingston 
Published: December 2019

AbstractThis paper looks at the use of metaphor and its effect on the interpretation of the ‘quality of law’ in Art. 8 cases of the European Court of Human Rights. It demonstrates the Court's reproduction of specific metaphorical frames ‐ a finding consistent with the use of metaphor in judgment experiments in cognitive linguistics. The Court employs metaphors conceptually coherent with those used in their cited precedent, in their representation of the successful pleadings within their judgments and insists (implicitly) on different metaphors in dissent. This paper argues that the use of congruent metaphors may be indicative of metaphor as a contributing factor in how judges reason. In the least, it is a significantly understudied phenomenon and this paper provides evidence for the salience of its approach for understanding judicial reasoning.
Quantitative relationship between microstructure characteristics and fatigue parameters of A319 casting alloy
Authors: Ge Bin , Liu Xiaoshan , He Guoqiu , Le Peiwen , Wen Zhenzhen , Wang Qigui 
Published: December 2019

AbstractThis paper describes a microstructure‐based uniaxial strain‐controlled fatigue life prediction model applied to A319 aluminum alloy which is widely used in automobile industry. The materials made with different casting conditions are characterized and quantified in terms of secondary dendrite arm spacing (SDAS), size, and aspect ratio of eutectic Si particles. Uniaxial low cycle fatigue tests have been performed on four groups of A319 alloy under different casting conditions in which cooling rate and Sr addition are variables. It is shown that the effect of various degrees of microstructure on the fatigue life and fatigue behavior is obvious. The first part of the paper is quantitatively characterizing the microstructure of samples to identify the influence of different casting conditions. With regard to mechanic properties, the tensile properties and fatigue behavior of samples are analyzed combining with microstructure. Finally, a microstructure‐based Manson‐Coffin‐Basquin model is proposed to predict fatigue life of Al‐Si alloy.
CogEvo, a cognitive function balancer, is a sensitive and easy psychiatric test battery for age‐related cognitive decline
Authors: Ichii Sadanobu , Nakamura Takumi , Kawarabayashi Takeshi , Takatama Masamitsu , Ohgami Tetsuya , Ihara Kazushige , Shoji Mikio 
Published: December 2019

AimWe examined whether a newly developed computer‐aided neuropsychiatric series of test, CogEvo, is necessary and sufficient for the evaluation of cognitive function in older people.MethodsA total of 272 participants in worthwhile life activity for the prevention of decline in mobility and cognitive function were administered tests every week at 33 locations in Fukaura‐machi, Japan. Basic profile information, a Mini‐Mental State Examination (MMSE), a CogEvo and a clock drawing test were used in the present study.ResultsOur results are summarized as: (i) the total score of the CogEvo and MMSE tests decreased significantly according to age and in age group analysis; (ii) scores from the CogEvo and MMSE tests showed a significant correlation; (iii) MMSE scores showed marked ceiling effects; (iv) analysis of cognitive domains, such as orientation, attention, memory and executive function, and spatial cognition using CogEvo showed significant age‐dependent impairment; (v) CogEvo discriminated three score groups of MMSE results with sensitivity and specificity of 70% and 60% in the <23 score group, 78% and 54% in the 24–26 score group, and 85% and 70% in the >27 score group, respectively; (vi) CogEvo memory tests reflected more detailed recall function than registration function; and (vii) CogEvo spatial cognition test results were correlated with test items of the MMSE and clock drawing tests.ConclusionsCogEvo is an easy and potentially useful computer‐aided test battery that can be used to evaluate age‐related or pathological decline in cognitive function from middle age and in preclinical stages of dementia. Geriatr Gerontol Int 2019; ••: ••–••.
Promoting oral HIV self‐testing via the internet among men who have sex with men in China: a feasibility assessment
Authors: Wang X , Tang Z , Wu Z , Nong Q , Li Y 
Published: December 2019

ObjectivesThe HIV prevalence among Chinese men who have sex with men (MSM) is high, while the HIV testing rate is low. HIV self‐testing (HIVST) is a promising means of scaling up HIV testing among MSM in China, as the ability to test in private is appealing to many individuals. We evaluated the feasibility of promoting oral HIVST via the internet in the MSM population.MethodsFrom April 2013 to April 2014, MSM in two major cities in China were recruited for an observational study with assessment at baseline and follow‐up. Data were collected via questionnaire, oral HIVST, and clinic‐based HIV confirmatory testing.ResultsA total of 510 MSM were recruited at baseline and 279 (54.7%) returned for a clinic follow‐up visit. Compared to MSM recruited via peer referral, those recruited via the internet were better educated, had a higher monthly income, sought and met male sex partners online more frequently, had less often tested or orally tested for HIV before, and being more likely to seek HIV knowledge or HIV intervention information online. The sensitivity of oral HIVST among MSM recruited via the internet was 92.9%, and the specificity was 96.8%. A total of 19.0% of MSM sought both male sex partners and HIV intervention programmes online. The associated factors were > 10 past male sex partners and ever testing for HIV using an oral self‐test kit. All MSM who were followed up re‐administered oral HIVST, yet fewer MSM recruited via the internet accepted blood retesting than other MSM.ConclusionsPromoting oral HIVST via the internet could be a feasible and promising approach to facilitate HIV testing among MSM in China.
Internal Mobility and Family Commitment of Foreigners in Italy
Authors: Rimoldi S.M.L. , Barbiano di Belgiojoso E. , Terzera L. 
Published: December 2019

AbstractThe internal movements of migrants are less frequently studied than international migration, although they have important labour, social, welfare and immigrant policy implications. By assuming the family as the unit of analysis, this paper examines the mechanism of selection between the foreigners who move internally and who do not, in Italy. Hypotheses are that having a family, improved economic performance, incorrect information about the first location, and discrimination, increase the propensity to move. Data come from the Italian survey “Social Condition and Integration of Foreign Citizens” (Istat 2011–2012). Results of the models show that internal migration is positively associated with family commitment, scant knowledge of the first destination, and no welcoming network. The paper enlarges the literature by stressing the intertwines between internal and international migration and the family commitment as the main driver of internal mobility of foreigners in Italy.
Effects of photoelectric therapy on proliferation and apoptosis of scar cells by regulating the expression of microRNA‐206 and its related mechanisms
Authors: Zhang Song , Zhao Zhen‐Min , Xue Hong‐Yu , Nie Fang‐Fei 
Published: December 2019

AbstractHuman skin fibroblast (HSF) cells were irradiated with different energy lasers to detect cell proliferation, apoptosis, and expression of microRNA‐206 and protein, and to further summarise the therapeutic effect of laser on scar cells. Human scar cell line HSF cells were cultured in three groups. The control group was not irradiated by laser, the low‐energy group was irradiated by 10 J/cm2 laser, and the high‐energy group was irradiated by 20 J/cm2 laser. After irradiation, HSF cells were cultured for 20 hours. Cell proliferation was detected by MTT assay. Cell cycle and apoptosis were detected by flow cytometry. Transwell migration assay was used to detect cell migratory ability. Reverse transcription polymerase chain reaction (RT‐PCR) was used to detect miR‐206 and mTOR gene levels. The levels of MMP‐9, Bax, Bcl‐2, cyclin D1, and mTOR signalling pathway proteins were detected by Western blotting assays. The results showed that after laser irradiation, the proliferation of cells decreased, and the difference between the control group and the experimental group was significant (P < .05). The higher the energy was, the greater the upregulation of apoptosis was. Apoptosis and cell migration increased (P < .05). The expressions of microRNA‐206, MMP‐9, and Bax were upregulated, while the expressions of mTOR, Bcl‐2, and cyclin D1 were downregulated. To sum up, laser irradiation can significantly inhibit the proliferation of HSF cells, affect cell cycle, and increase cell apoptosis and migratory ability.