bluuebunny/crossref_metadata_2025_split huggingface dataset:
A fuzzy mid-term capacity and production planning model for a manufacturing system with cloud-based capacity
Authors: Chen Tin-Chih Toly , Wang Yu-Cheng 
Published: July 2020

AbstractMost of the past cloud manufacturing (CMfg) studies investigated the short-term production planning or job scheduling of a CMfg system, while the mid-term or long-term capacity and production planning of a CMfg system has rarely been addressed. In addition, most existing methods are suitable for CMfg systems comprising three-dimensional (3D) printers, computer numerical control (CNC) machines or robots, but ignore the coordination and transportation required for moving jobs across factories. To fill these gaps, a fuzzy mid-term capacity and production planning model for a manufacturer with cloud-based capacity is proposed in this study. The proposed methodology guides a manufacturer in choosing between non-cloud-based capacity and cloud-based capacity. It can be applied to factories utilizing machines with different degrees of automation including highly automatic equipment (such as 3D printers, CNC machines, and robots) and lowly automatic (legacy) machines, while existing methods assume that orders can be easily transferred between machines that are often highly automatic. In the proposed methodology, first, various types of capacity are unequally prioritized. Then, a fuzzy mixed-integer nonlinear programming model is formulated and optimized to make the mid-term or long-term capacity and production plan of a factory. The fuzzy capacity and production planning model is designed for factories with parallel machines. The proposed methodology has been applied to a case to illustrate its applicability. According to the experimental results, the proposed methodology successfully reduced total costs by up to 8%. The advantage of the proposed methodology over existing practices in fulfilling customers’ demand was also obvious.
Patient-level predictors of detection of depressive symptoms, referral, and uptake of depression counseling among chronic care patients in KwaZulu-Natal, South Africa
Authors: Kemp Christopher G. , Mntambo Ntokozo , Bachmann Max , Bhana Arvin , Rao Deepa , Grant Merridy , Hughes James P. , Simoni Jane M. , Weiner Bryan J. , Gigaba Sithabisile Gugulethu , Luvuno Zamasomi Prudence Busisiwe , Petersen Inge 
Published: July 2020

Abstract

Background
Integration of depression treatment into primary care could improve patient outcomes in low-resource settings. Losses along the depression care cascade limit integrated service effectiveness. This study identified patient-level factors that predicted detection of depressive symptoms by nurses, referral for depression treatment, and uptake of counseling, as part of integrated care in KwaZulu-Natal, South Africa.

Methods
This was an analysis of baseline data from a prospective cohort. Participants were adult patients with at least moderate depressive symptoms at primary care facilities in Amajuba, KwaZulu-Natal, South Africa. Participants were screened for depressive symptoms prior to routine assessment by a nurse. Generalized linear mixed-effects models were used to estimate associations between patient characteristics and service delivery outcomes.

Results
Data from 412 participants were analyzed. Nurses successfully detected depressive symptoms in 208 [50.5%, 95% confidence interval (CI) 38.9–62.0] participants; of these, they referred 76 (36.5%, 95% CI 20.3–56.5) for depression treatment; of these, 18 (23.7%, 95% CI 10.7–44.6) attended at least one session of depression counseling. Depressive symptom severity, alcohol use severity, and perceived stress were associated with detection. Similar factors did not drive referral or counseling uptake.

Conclusions
Nurses detected patients with depressive symptoms at rates comparable to primary care providers in high-resource settings, though gaps in referral and uptake persist. Nurses were more likely to detect symptoms among patients in more severe mental distress. Implementation strategies for integrated mental health care in low-resource settings should target improved rates of detection, referral, and uptake.
Time to positivity of blood cultures among a veteran population: How long to wait before discontinuing antimicrobial therapy when suspicion of infection is low
Authors: Heintz Brett H. , DeLanoit Zach T. , Granroth Leah J. , Patterson Whitni T. 
Published: July 2020

AbstractTime to positivity (TTP) of blood cultures can guide antimicrobial therapy. This single-center retrospective cohort study aimed to determine the yield of clinically significant organisms from blood cultures that were initially negative at 24 hours. Clinically significant organisms were uncommon after 24 hours (1.5%) and more common in intensive care unit settings.
GAMES AND REFLECTION IN
Authors: AGUILERA J. P. 
Published: July 2020

AbstractWe characterize the determinacy of
$F_\sigma $
games of length
$\omega ^2$
in terms of determinacy assertions for short games. Specifically, we show that
$F_\sigma $
games of length
$\omega ^2$
are determined if, and only if, there is a transitive model of
${\mathsf {KP}}+{\mathsf {AD}}$
containing
$\mathbb {R}$
and reflecting
$\Pi _1$
facts about the next admissible set.As a consequence, one obtains that, over the base theory
${\mathsf {KP}} + {\mathsf {DC}} + ``\mathbb {R}$
exists,” determinacy for
$F_\sigma $
games of length
$\omega ^2$
is stronger than
${\mathsf {AD}}$
, but weaker than
${\mathsf {AD}} + \Sigma _1$
-separation.
Sir Robert Hart and the Writing of Modern Chinese History
Authors: Chang Chihyun 
Published: July 2020

AbstractThis article examines the conflicts in writing the imperial modern history of China among various stakeholders, particularly Chinese and American historians, and their dealing with a set of personal documents of Sir Robert Hart, Inspector-General of the Chinese Maritime Customs Services (CMCS) during the Qing period. This set of documents is called “Hart Industry” and contains Hart's personal papers and seventy-seven volumes of diaries, among others. Revealing the imperial Inspector-General's view on “westernization” in modern China, the Hart Industry played a key role in the development of the history of modern China throughout the twentieth century. From around 1957 until 1995, the diaries became a source of a highly politicized academic debate between Chinese Communist historians of the People's Republic of China and western historians of the Hart Industry. By providing a “study of studies” on the historiography of the colonial modern history of China, this article argues that the Hart diaries were critical to historians’ understanding of their own academic discourse.
TWO LEVEL CREDIBILITY-LIMITED REVISIONS
Authors: GARAPA MARCO 
Published: July 2020

AbstractIn this paper, we propose a new kind of nonprioritized operator which we call two level credibility-limited revision. When revising through a two level credibility-limited revision there are two levels of credibility and one of incredibility. When revising by a sentence at the highest level of credibility, the operator behaves as a standard revision, if the sentence is at the second level of credibility, then the outcome of the revision process coincides with a standard contraction by the negation of that sentence. If the sentence is not credible, then the original belief set remains unchanged. In this article, we axiomatically characterize several classes of two level credibility-limited revision operators.
EPISTEMIC MULTILATERAL LOGIC
Authors: INCURVATI LUCA , SCHLÖDER JULIAN J. 
Published: July 2020

AbstractWe presentepistemic multilateral logic, a general logical framework for reasoning involving epistemic modality. Standard bilateral systems use propositional formulae marked with signs for assertion and rejection. Epistemic multilateral logic extends standard bilateral systems with a sign for the speech act of weak assertion (Incurvati & Schlöder, 2019) and an operator for epistemic modality. We prove that epistemic multilateral logic is sound and complete with respect to the modal logic$\mathbf {S5}$modulo an appropriate translation. The logical framework developed provides the basis for a novel, proof-theoretic approach to the study of epistemic modality. To demonstrate the fruitfulness of the approach, we show how the framework allows us to reconcile classical logic with the contradictoriness of so-called Yalcin sentences and to distinguish between various inference patterns on the basis of the epistemic properties they preserve.
Survey of ground and aerial herbicide application practices in Arkansas agronomic crops
Authors: Butts Thomas R. , Barber L. Tom , Norsworthy Jason K. , Davis Jason 
Published: July 2020

AbstractA thorough understanding of commonly used herbicide application practices and technologies is needed to provide recommendations and determine necessary application education efforts. An online survey to assess ground and aerial herbicide application practices in Arkansas was made available online in spring 2019. The survey was direct-emailed to 272 agricultural aviators and 831 certified commercial pesticide applicators, as well as made publicly available online through multiple media sources. A total of 124 responses were received, of which 75 responses were specific to herbicide applications in Arkansas agronomic crops, accounting for approximately 49% of Arkansas’ planted agronomic crop hectares in 2019. Ground and aerial application equipment were used for 49% and 51% of the herbicide applications on reported hectares, respectively. Rate controllers were commonly used application technologies for both ground and aerial application equipment. In contrast, global positioning system-driven automatic nozzle and boom shut-offs were much more common on ground spray equipment than aerial equipment. Applicator knowledge of nozzles and usage was limited, regardless of ground or aerial applicators, as only 28% of respondents provided a specific nozzle type used, indicating a need for educational efforts on nozzles and their importance in herbicide applications. Of the reported nozzle types, venturi nozzles and straight-stream nozzles were the most commonly used for ground and aerial spray equipment, respectively. Spray carrier volumes of 96.3 and 118.8 L ha−1 for ground spray equipment and 49.6 and 59.9 L ha−1 for aerial application equipment were the means of reported spray volumes for systemic and contact herbicides, respectively. Respondents indicated application optimization was a major benefit of utilizing newer application technologies, herbicide drift was a primary challenge, and research needs expressed by respondents included adjuvants, spray volume efficacy, and herbicide drift. Findings from this survey provided insight into current practices, technologies, and needs of Arkansas herbicide applicators. Research and education efforts can be implemented as a result to address aforementioned needs while providing applied research-based information to applicators based on current practices.
Locating Fully Locked Asperities Along the South America Subduction Megathrust: A New Physical Interseismic Inversion Approach in a Bayesian Framework
Authors: Herman M. W. , Govers R. 
Published: July 2020

AbstractThe largest earthquakes in subduction zones occur where significant interseismic slip deficit has accumulated on the plate interface. Slip deficit accumulates most quickly in mechanically locked regions, and these also cause the regions around them to accumulate slip deficit; therefore, large earthquakes are typically expected to rupture in and around locked areas. The locations and dimensions of these locked zones have been difficult to resolve using standard techniques and available data sets. We develop a new statistical interseismic inversion approach that incorporates the physical interactions between nearby fault areas to directly determine the distribution of locking on the subduction plate interface (simultaneously with rigid forearc motions) from interseismic surface velocities. Because we include physical prior information in the inversion procedure, this approach reduces uncertainties in the rate of slip deficit accumulation, even in locations (such as near the trench) where kinematic inversions of onshore data have relatively low resolution. Applying the inversion to the South America subduction zone, we find that the pattern of locking and corresponding slip deficit rates correlate well with recent and historical large earthquake ruptures. Locked patch dimensions are <40 km and account for no more than 30% of the area of the plate interface. The small size of the imaged locked zones is a natural outcome of our physical assumptions and implies that mechanical locking is caused by correspondingly small geological features. Despite their small dimensions, locked zones generate substantial slip deficit on the surrounding plate interface, consistent with the slip patterns of large megathrust earthquakes.
Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer
Authors: Ferris Jennifer , Espona-Fiedler Margarita , Hamilton Claudia , Holohan Caitriona , Crawford Nyree , McIntyre Alex J. , Roberts Jamie Z. , Wappett Mark , McDade Simon S. , Longley Daniel B. , Coyle Victoria 
Published: July 2020

AbstractPevonedistat (MLN4924), a selective inhibitor of the NEDD8-activating enzyme E1 regulatory subunit (NAE1), has demonstrated significant therapeutic potential in several malignancies. Although multiple mechanisms-of-action have been identified, how MLN4924 induces cell death and its potential as a combinatorial agent with standard-of-care (SoC) chemotherapy in colorectal cancer (CRC) remains largely undefined. In an effort to understand MLN4924-induced cell death in CRC, we identified p53 as an important mediator of the apoptotic response to MLN4924. We also identified roles for the extrinsic (TRAIL-R2/caspase-8) and intrinsic (BAX/BAK) apoptotic pathways in mediating the apoptotic effects of MLN4924 in CRC cells, as well as a role for BID, which modulates a cross-talk between these pathways. Depletion of the anti-apoptotic protein FLIP, which we identify as a novel mediator of resistance to MLN4924, enhanced apoptosis in a p53-, TRAIL-R2/DR5-, and caspase-8-dependent manner. Notably, TRAIL-R2 was involved in potentiating the apoptotic response to MLN4924 in the absence of FLIP, in a ligand-independent manner. Moreoever, when paired with SoC chemotherapies, MLN4924 demonstrated synergy with the irinotecan metabolite SN38. The cell death induced by MLN4924/SN38 combination was dependent on activation of mitochondria through BAX/BAK, but in a p53-independent manner, an important observation given the high frequency of TP53 mutation(s) in advanced CRC. These results uncover mechanisms of cell death induced by MLN4924 and suggest that this second-generation proteostasis-disrupting agent may have its most widespread activity in CRC, in combination with irinotecan-containing treatment regimens.
A global lipid map defines a network essential for Zika virus replication
Authors: Leier Hans C. , Weinstein Jules B. , Kyle Jennifer E. , Lee Joon-Yong , Bramer Lisa M. , Stratton Kelly G. , Kempthorne Douglas , Navratil Aaron R. , Tafesse Endale G. , Hornemann Thorsten , Messer William B. , Dennis Edward A. , Metz Thomas O. , Barklis Eric , Tafesse Fikadu G. 
Published: July 2020

AbstractZika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form replication sites. How ZIKV dysregulates lipid networks to allow this, and consequences for disease, is poorly understood. Here, we perform comprehensive lipidomics to create a lipid network map during ZIKV infection. We find that ZIKV significantly alters host lipid composition, with the most striking changes seen within subclasses of sphingolipids. Ectopic expression of ZIKV NS4B protein results in similar changes, demonstrating a role for NS4B in modulating sphingolipid pathways. Disruption of sphingolipid biosynthesis in various cell types, including human neural progenitor cells, blocks ZIKV infection. Additionally, the sphingolipid ceramide redistributes to ZIKV replication sites, and increasing ceramide levels by multiple pathways sensitizes cells to ZIKV infection. Thus, we identify a sphingolipid metabolic network with a critical role in ZIKV replication and show that ceramide flux is a key mediator of ZIKV infection.
Gate-tunable spin-galvanic effect in graphene-topological insulator van der Waals heterostructures at room temperature
Authors: Khokhriakov Dmitrii , Hoque Anamul Md. , Karpiak Bogdan , Dash Saroj P. 
Published: July 2020

AbstractUnique electronic spin textures in topological states of matter are promising for emerging spin-orbit driven memory and logic technologies. However, there are several challenges related to the enhancement of their performance, electrical gate-tunability, interference from trivial bulk states, and heterostructure interfaces. We address these challenges by integrating two-dimensional graphene with a three-dimensional topological insulator (TI) in van der Waals heterostructures to take advantage of their remarkable spintronic properties and engineer proximity-induced spin-charge conversion phenomena. In these heterostructures, we experimentally demonstrate a gate-tunable spin-galvanic effect (SGE) at room temperature, allowing for efficient conversion of a non-equilibrium spin polarization into a transverse charge current. Systematic measurements of SGE in various device geometries via a spin switch, spin precession, and magnetization rotation experiments establish the robustness of spin-charge conversion in the Gr-TI heterostructures. Importantly, using a gate voltage, we reveal a strong electric field tunability of both amplitude and sign of the spin-galvanic signal. These findings provide an efficient route for realizing all-electrical and gate-tunable spin-orbit technology using TIs and graphene in heterostructures, which can enhance the performance and reduce power dissipation in spintronic circuits.
Genome-wide analysis of diamondback moth, Plutella xylostella L., from Brassica crops and wild host plants reveals no genetic structure in Australia
Authors: Perry Kym D. , Keller Michael A. , Baxter Simon W. 
Published: July 2020

AbstractMolecular studies of population structure can reveal insight into the movement patterns of mobile insect pests in agricultural landscapes. The diamondback moth, Plutella xylostella L., a destructive pest of Brassica vegetable and oilseed crops worldwide, seasonally colonizes winter canola crops in southern Australia from alternative host plant sources. To investigate movement, we collected 59 P. xylostella populations from canola crops, Brassica vegetable and forage crops and brassicaceous wild host plants throughout southern Australia in 2014 and 2015 and genotyped 833 individuals using RAD-seq for genome-wide analysis. Despite a geographic sampling scale > 3,000 km and a statistically powerful set of 1,032 SNP markers, there was no genetic differentiation among P. xylostella populations irrespective of geographic location, host plant or sampling year, and no evidence for isolation-by-distance. Hierarchical STRUCTURE analysis at K = 2–5 showed nearly uniform ancestry in both years. Cluster analysis showed divergence of a small number of individuals at several locations, possibly reflecting an artefact of sampling related individuals. It is likely that genetic homogeneity within Australian P. xylostella largely reflects the recent colonization history of this species but is maintained through some level of present gene flow. Use of genome-wide neutral markers was uninformative for revealing the seasonal movements of P. xylostella within Australia, but may provide more insight in other global regions where the species has higher genetic diversity.
Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth
Authors: Hezelgrave Natasha L. , Seed Paul T. , Chin-Smith Evonne C. , Ridout Alexandra E. , Shennan Andrew H. , Tribe Rachel M. 
Published: July 2020

AbstractThere is much interest in the role of innate immune system proteins (antimicrobial peptides) in the inflammatory process associated with spontaneous preterm birth (sPTB). After promising pilot work, we aimed to validate the association between the antimicrobial peptides/proteins elafin and cathelicidin and sPTB. An observational cohort study of 405 women at high-risk, and 214 women at low-risk of sPTB. Protein concentrations of elafin and cathelicidin, and the enzyme human neutrophil elastase (HNE) were measured in over 1,000 cervicovaginal fluid (CVF) samples (10 to 24 weeks’ gestation). Adjusted CVF cathelicidin and HNE concentrations (but not elafin) were raised in high-risk women who developed cervical shortening and who delivered prematurely and were predictive of sPTB < 37 weeks, with an area under the curve (AUC) of 0.75 (95% CI 0.68 to 0.81) for cathelicidin concentration at 14 to 15+6 weeks. Elafin concentrations were affected by gestation, body mass index and smoking. CVF elafin in early pregnancy was modestly predictive of sPTB < 34 weeks (AUC 0.63, 0.56–0.70). Alterations in innate immune response proteins in early pregnancy are predictive of sPTB. Further investigation is warranted to understand the drivers for this, and their potential to contribute towards clinically useful prediction techniques.
The evolution of knowledge within and across fields in modern physics
Authors: Sun Ye , Latora Vito 
Published: July 2020

AbstractThe exchange of knowledge across different areas and disciplines plays a key role in the process of knowledge creation, and can stimulate innovation and the emergence of new fields. We develop here a quantitative framework to extract significant dependencies among scientific disciplines and turn them into a time-varying network whose nodes are the different fields, while the weighted links represent the flow of knowledge from one field to another at a given period of time. Drawing on a comprehensive data set on scientific production in modern physics and on the patterns of citations between articles published in the various fields in the last 30 years, we are then able to map, over time, how the ideas developed in a given field in a certain time period have influenced later discoveries in the same field or in other fields. The analysis of knowledge flows internal to each field displays a remarkable variety of temporal behaviours, with some fields of physics showing to be more self-referential than others. The temporal networks of knowledge exchanges across fields reveal cases of one field continuously absorbing knowledge from another field in the entire observed period, pairs of fields mutually influencing each other, but also cases of evolution from absorbing to mutual or even to back-nurture behaviors.