bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renaming States—A Case Study: Changing the Name of the Hungarian State in 2011. Its Background, Reasons, and Aftermath
Authors: Takács Peter 
Published: March 2020

AbstractA provision of the Hungarian constitution, adopted in 2011, has renamed the state. The name changed from theRepublic of HungarytoHungary, while the form of the state has remained “republic”. The purpose of this study is to explore the meaning, significance, and several consequences of this provision. The analysis consists of three main parts. The first one gives a general overview of the functions of the names of states. It claims that not only names but also changing or modifying names of states—taking place either by name-giving or by shaping convention—can serve certain functions. The second part focuses on the historical and constitutional details of renaming the Hungarian state, and summarizes the legal context that provided the framework for the 2011 renaming. The third part outlines the arguments for the change, takes a look at the official justification and actual reasons, and reveals some of the consequences of the name change in the past decade. The main contention of the paper is that the renaming of the Hungarian state that took place in 2011 lacked any overt and reasonable justification, and is best explained as an expression of anti-republican sentiment, which indicated, and partly paved the way for the transition into a kind of an authoritarian regime. Finally, the study raises a possible interpretation of the renaming of the Hungarian state in 2011, the point of which is that it adumbrated many later changes in public law and political systems.
Oscillatory Convection Onset in a Porous Rectangle with Non-analytical Corners
Authors: Tyvand Peder Albert , Nøland Jonas Kristiansen 
Published: March 2020

AbstractThe analytical theory on Darcy–Bénard convection is dominated by normal-mode approaches, which essentially reduce the spatial order from four to two. This paper goes beyond the normal-mode paradigm of convection onset in a porous rectangle. A handpicked case where all four corners of the rectangle are non-analytical is therefore investigated. The marginal state is oscillatory with one-way horizontal wave propagation. The time-periodic convection pattern has no spatial periodicity and requires heavy numerical computation by the finite element method. The critical Rayleigh number at convection onset is computed, with its associated frequency of oscillation. Snapshots of the 2D eigenfunctions for the flow field and temperature field are plotted. Detailed local gradient analyses near two corners indicate that they hide logarithmic singularities, where the displayed eigenfunctions may represent outer solutions in matched asymptotic expansions. The results are validated with respect to the asymptotic limit of Nield (Water Resour Res 11:553–560, 1968).
Inter-letter spacing, inter-word spacing, and font with dyslexia-friendly features: testing text readability in people with and without dyslexia
Authors: Galliussi Jessica , Perondi Luciano , Chia Giuseppe , Gerbino Walter , Bernardis Paolo 
Published: March 2020

AbstractOver the last years, several studies have suggested a possible link between dyslexia and deficits in low-level visual processing (e.g., excessive crowding). At the same time, specially designed “dyslexia-friendly” fonts appeared on the market. This class of fonts presents two main features: the particular graphic characteristics of the letterform designed to avoid confusion between similarly shaped letters, and wider inter-letter and inter-word spacing to limit crowding. The literature testing the efficacy of “dyslexia-friendly” fonts in improving reading accuracy and increasing reading speed is controversial. We evaluated the impact of letterform (with vs. without dyslexia-friendly graphic features), inter-letter spacing (standard vs. increased), and inter-word spacing (standard vs. increased) on reading accuracy and speed. Two groups of 64 children each, with and without dyslexia, read aloud 8 equivalent texts. The data collected failed to show any effect from the letterform. As regards spacing, the data showed that reading speed is impaired by an increase in inter-letter spacing not combined with an adequate increase in inter-word spacing.
Isolation of Bordetella trematum from the respiratory tract of a patient with lung cancer: a case report
Authors: Kukla Rudolf , Svarc Michal , Bolehovska Radka , Ryskova Lenka , Paterova Pavla , Fajfr Miroslav , Malisova Lucia , Zemlickova Helena 
Published: March 2020

AbstractWe report the case of isolation ofBordetella trematumfrom the respiratory tract of a patient with lung carcinoma. This gram-negative, opportunistic rod was firstly described in 1996. To date, only several strains ofBordetella trematumhave been isolated and reported, mostly from skin and soft tissue infections. The patient was admitted to the ICU of the Pulmonary Department in incipient septic shock with respiratory failure. Intravenous fluid resuscitation and non-invasive ventilation were administered immediately. A broad spectrum antibiotic piperacillin/tazobactam was administered empirically after sampling of material for microbiological examination. The bronchoscopy showed a large cavern of decayed tumour invading into mediastinum. Both sample cultures showed significant quantities of gram-negative non-fermenting bacteria. The isolate was identified using MALDI-TOF MS asBordetella trematumand the identification was confirmed using 16S ribosomal RNA sequencing. In the last few years, routine bacterial identification using MALDI-TOF MS has enabled correct discrimination of this species. Nevertheless, isolation ofBordetella trematumin clinical samples is still very uncommon, and it is appropriate to confirm the species identification via 16S ribosomal RNA sequencing. To our knowledge, this is the first case ofB. trematumisolated from the human respiratory tract since its first description. The clinical significance ofBordetella trematumin the rapid deterioration of the patient’s status remains unclear.
Alternative and complementary therapies in osteoarthritis and cartilage repair
Authors: Fuggle N. R. , Cooper C. , Oreffo R. O. C. , Price A. J. , Kaux J. F. , Maheu E. , Cutolo M. , Honvo G. , Conaghan P. G. , Berenbaum F. , Branco J. , Brandi M. L. , Cortet B. , Veronese N. , Kurth A. A. , Matijevic R. , Roth R. , Pelletier J. P. , Martel-Pelletier J. , Vlaskovska M. , Thomas T. , Lems W. F. , Al-Daghri N. , Bruyère O. , Rizzoli R. , Kanis J. A. , Reginster J. Y. 
Published: March 2020

AbstractOsteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of ‘alternative’ therapies. These alternative therapies may have a limited evidence base and, for this reason, are often only afforded brief reference (or completely excluded) from current OA guidelines. Thus, the aim of this review was to synthesize the current evidence regarding autologous chondrocyte implantation (ACI), mesenchymal stem cell (MSC) therapy, platelet-rich plasma (PRP), vitamin D and other alternative therapies. The majority of studies were in knee OA or chondral defects. Matrix-assisted ACI has demonstrated exceedingly limited, symptomatic improvements in the treatment of cartilage defects of the knee and is not supported for the treatment of knee OA. There is some evidence to suggest symptomatic improvement with MSC injection in knee OA, with the suggestion of minimal structural improvement demonstrated on MRI and there are positive signals that PRP may also lead to symptomatic improvement, though variation in preparation makes inter-study comparison difficult. There is variability in findings with vitamin D supplementation in OA, and the only recommendation which can be made, at this time, is for replacement when vitamin D is deplete. Other alternative therapies reviewed have some evidence (though from small, poor-quality studies) to support improvement in symptoms and again there is often a wide variation in dosage and regimens. For all these therapeutic modalities, although controlled studies have been undertaken to evaluate effectiveness in OA, these have often been of small size, limited statistical power, uncertain blindness and using various methodologies. These deficiencies must leave the question as to whether they have been validated as effective therapies in OA (or chondral defects). The conclusions of this review are that all alternative interventions definitely require clinical trials with robust methodology, to assess their efficacy and safety in the treatment of OA beyond contextual and placebo effects.
The longitudinal role of mathematics anxiety in mathematics development: Issues of gender differences and domain‐specificity
Authors: Wang Zhe , Rimfeld Kaili , Shakeshaft Nicholas , Schofield Kerry , Malanchini Margherita 
Published: March 2020

ABSTRACTIntroductionMathematics anxiety (MA) is an important risk factor hindering the development of confidence and capability in mathematics and participation in the science, technology, engineering, and mathematics workforce. The aim of the present study is to further our understanding of these relations in adolescence by adopting a threefold approach. First, we adopted a longitudinal design to clarify the temporal order in the developmental relations between (a) MA and mathematics achievement and (b) MA and mathematics self‐perceived ability. Second, we investigated whether the developmental relations between MA and mathematics achievement/self‐perceived ability differed between boys and girls. Finally, we explored the domain‐specificity of MA by examining its role in foreign language (L2) learning.MethodsData were collected from 1043 Italian high school students. Students reported their anxiety, self‐perceived ability, and school achievement in mathematics and L2 over two separate waves, one semester apart.ResultsUsing multi‐group cross‐lagged panel analyses, we found that (a) mathematics achievement predicted MA longitudinally, whereas MA did not predict subsequent mathematics achievement; (b) there was a negative reciprocal relation between MA and mathematics self‐perceived ability in male, but not female students; and (c) there were longitudinal relations between MA and L2 achievement and self‐perceived ability above and beyond L2 anxiety.ConclusionsThese findings support the deficit view of the developmental relation between MA and mathematics achievement, highlight high school male students as a vulnerable group evincing vicious transactions between high anxiety and low self‐efficacy in mathematics, and reveal the importance of internal cross‐domain comparison processes in MA development.
Bed topography and subglacial landforms in the onset region of the Northeast Greenland Ice Stream
Authors: Franke Steven , Jansen Daniela , Binder Tobias , Dörr Nils , Helm Veit , Paden John , Steinhage Daniel , Eisen Olaf 
Published: March 2020

AbstractThe Northeast Greenland Ice Stream (NEGIS) is an important dynamic component for the total mass balance of the Greenland ice sheet, as it reaches up to the central divide and drains 12% of the ice sheet. The geometric boundary conditions and in particular the nature of the subglacial bed of the NEGIS are essential to understand its ice flow dynamics. We present a record of more than 8000 km of radar survey lines of multi-channel, ultra-wideband radio echo sounding data covering an area of 24 000 km2, centered on the drill site for the East Greenland Ice-core Project (EGRIP), in the upper part of the NEGIS catchment. Our data yield a new detailed model of ice-thickness distribution and basal topography in the region. The enhanced resolution of our bed topography model shows features which we interpret to be caused by erosional activity, potentially over several glacial–interglacial cycles. Off-nadir reflections from the ice–bed interface in the center of the ice stream indicate a streamlined bed with elongated subglacial landforms. Our new bed topography model will help to improve the basal boundary conditions of NEGIS prescribed for ice flow models and thus foster an improved understanding of the ice-dynamic setting.
Over-winter persistence of supraglacial lakes on the Greenland Ice Sheet: results and insights from a new model
Authors: Law Robert , Arnold Neil , Benedek Corinne , Tedesco Marco , Banwell Alison , Willis Ian 
Published: March 2020

AbstractWe present a newly developed 1-D numerical energy-balance and phase transition supraglacial lake model: GlacierLake. GlacierLake incorporates snowfall, in situ snow and ice melt, incoming water from the surrounding catchment, ice lid formation, basal freeze-up and thermal stratification. Snow cover and temperature are varied to test lake development through winter and the maximum lid thickness is recorded. Average wintertime temperatures of −2 to$-30^{\circ }{\rm C}$and total snowfall of 0 to 3.45 m lead to a range of the maximum lid thickness from 1.2 to 2.8 m after${\sim }250$days, with snow cover exerting the dominant control. An initial ice temperature of$-15^{\circ }{\rm C}$with simulated advection of cold ice from upstream results in 0.6 m of basal freeze-up. This suggests that lakes with water depths above 1.3 to 3.4 m (dependent on winter snowfall and temperature) upon lid formation will persist through winter. These buried lakes can provide a sizeable water store at the start of the melt season, expedite future lake formation and warm underlying ice even in winter.
GLOBAL SCIENCE, NATIONAL HORIZONS: SOUTH AFRICA IN DEEP TIME AND SPACE
Authors: DUBOW SAUL 
Published: March 2020

AbstractIn his inaugural lecture, Saul Dubow, Smuts Professor of Commonwealth History at Cambridge University, discusses the modern history of science in South Africa in terms of ‘deep time’ and space, drawing links between developments in astronomy, palaeontology, and Antarctic research. He argues that Jan Smuts's synthetic discussion of South African science in 1925, followed by J. H. Hofmeyr's discussion of the ‘South Africanization’ of science in 1929, has parallels in post-apartheid conceptions of scientific-led nation-building, for example in Thabo Mbeki's elaboration of the ‘African Renaissance’. Yet, whereas the vision of science elaborated by Smuts was geared exclusively to white unity, Mbeki's Africanist vision of South African science was ostensibly more inclusive. The lecture concludes by considering South Africa as one of several middle order countries which have used national science and scientific patriotism to address experiences of colonialism and relations of inequality and to assert their influence in regional contexts.
Low-temperature storage of the poultry red mite, Dermanyssus gallinae, facilitates laboratory colony maintenance and population growth
Authors: Wang Chuanwen , Xu Xiaolin , Yu He , Huang Yu , Li Hao , Wan Qiang , Pan Baoliang 
Published: March 2020

AbstractThe poultry red mite, Dermanyssus gallinae, is currently the most common ectoparasite affecting egg-laying hens. Since continuous culture of D. gallinae on birds is a biologically and economically costly endeavour, storage techniques for mites are urgently needed. Effects of temperature on adult and nymph survival were first studied to optimize storage conditions. Then, fecundity of D. gallinae was studied after mites were stored at optimal storage conditions. Results showed the survival rates of protonymphs (42.11%), deutonymphs (8.19%) and females (19.78%) at 5°C after 84 days were higher than those at 0, 25 and 30°C. Thereafter the fecundity and the capability of re-establishing colonies of D. gallinae were evaluated after they were stored for 40 and 80 days at 5°C. After storage, the mean number of eggs showed no statistical difference between treated (5°C for 40 or 80 days) and control groups (25°C for 7 days), while the hatching rates of eggs were in all cases above 97%. The dynamic changes of mite populations and egg numbers showed similar trends to the control group after the stored adult or nymph mites were fed on chicks. Dermanyssus gallinae can be successfully stored at 5°C for 80 days with no interference with the fecundity of mites, and the stored mites could re-establish colonies successfully. Adults and nymphs were two main stages with capability for low temperature storage. These results suggest that low temperature storage is a viable option for colony maintenance of D. gallinae under laboratory conditions.
Analysis of regulatory T cells and CTLA-4 expression in pregnant women according to seropositivity toToxoplasma gondii
Authors: Rezende-Oliveira Karine , Gómez-Hernández César , da Silva Marcos Vinicius , Helmo Fernanda Rodrigues , Rodrigues Virmondes 
Published: March 2020

AbstractPregnancy is considered a period in which immunomodulation occurs, although it is important for the maintenance of the foetus, could contribute to infections asToxoplasma gondii. Immune response cells such as regulatory T cells participate in this immunomodulation, and surface molecules such as CTLA-4 develop an immunosuppressive role, could contribute to the establishment of the parasite. This study aimed to evaluate the presence of regulatory T cells and the expression of CTLA-4 in parturient and non-pregnant seropositive and seronegative for anti-T. gondiiantibodies. Sixty-two participants were evaluated, 14 parturient with negative serology, 23 parturient with positive serology, 16 non-pregnant women seronegative and 9 non-pregnant women seropositive. Immunophenotyping was performed for characterize TCD4+Foxp3+ cells, T CD4+CD25-Foxp3+, TCD4+CD25highFoxp3+, TCD4+CTLA-4+, TCD4+CD25-CTLA-4+ and TCD4+CD25highCTLA-4+. We observed a lower level of CD4+CD25highFoxp3+ cells from seropositive parturient compared with seropositive non-pregnant cells. Significative levels of CD4+CD25-Foxp3+ cells from seronegative pregnant were observed compared with seropositive pregnant cells. Furthermore, the higher level of CD4+CD25-CTLA-4+ cells populations was detected in seropositive pregnant cells compared with seropositive non-pregnant. Although a significant increase in CTLA-4 cells was observed in pregnant women positive for anti-T. gondiiantibodies, this increase did not cause a risk of reactivation of the infection.
Free-living amoebae and their relationship to air quality in hospital environments: characterization of Acanthamoeba spp. obtained from air-conditioning systems
Authors: Wopereis Débora Borgert , Bazzo Maria Luiza , de Macedo Jefferson Peres , Casara Fabiana , Golfeto Lisléia , Venancio Eduardo , de Oliveira Jaquelline Germano , Rott Marilise Brittes , Caumo Karin Silva 
Published: March 2020

AbstractFree-living amoebae (FLA) are widely dispersed in the environment, can cause opportunistic and non-opportunistic infections in humans and other animals. The aim of the present study was characterize FLA obtained from air-conditioners of a public hospital in the city of Florianópolis, SC, Brazil. Fifty-four dust samples were collected of air conditioners, and were inoculated on 1.5% non-nutrient agar, overlaid with layers of Escherichia coli. Subsequently the isolates were axenised in PYG growth medium. The morphological and molecular characterization of the isolates was performed, as well as the tolerance (physiological) assays were used to evaluate the pathogenic potential. The results revealed the presence of FLA in 42 (77.8%) of the collected samples. Of these, 39 (92.9%) axenic isolates of FLA were obtained for morphological and genotypic studies. All the isolates characterized belong to the genus Acanthamoeba. Nineteen (48.7%) isolates belong to the genotype T4, 16 (41.0%) to the T5 genotype and 4 (10.3%) to genotype T11. Seven (18.0%) isolates were considered potentially pathogenic in tolerance assays. These findings require attention, considering the isolation environment and immunocompromised characteristics of many hospitalized patients.
The Epidemiological Presentation Pattern of Ebola Virus Disease Outbreaks: Changes from 1976 to 2019
Authors: Arcos González Pedro , Fernández Camporro Ángel , Eriksson Anneli , Alonso Llada Carmen 
Published: March 2020

AbstractIntroduction:Ebola Virus Disease (EVD) is the international health emergency paradigm due to its epidemiological presentation pattern, impact on public health, resources necessary for its control, and need for a national and international response.Study Objective:The objective of this work is to study the evolution and progression of the epidemiological presentation profile of Ebola disease outbreaks since its discovery in 1976 to the present, and to explore the possible reasons for this evolution from different perspectives.Methods:Retrospective observational study of 38 outbreaks of Ebola disease occurred from 1976 through 2019, excluding laboratory accidents. United Nations agencies and programs; Ministries of Health; the US Centers for Disease Control and Prevention (CDC); ReliefWeb; emergency nongovernmental organizations; and publications indexed in PubMed, EmBase, and Clinical Key have been used as sources of data. Information on the year of the outbreak, date of beginning and end, duration of the outbreak in days, number of cases, number of deaths, population at risk, geographic extension affected in Km2, and time of notification of the first cases to the World Health Organization (WHO) have been searched and analyzed.Results:Populations at risk have increased (P = .024) and the geographical extent of Ebola outbreaks has grown (P = .004). Reporting time of the first cases of Ebola to WHO has been reduced (P = .017) and case fatality (P = .028) has gone from 88% to 62% in the period studied. There have been differences (P = .04) between the outbreaks produced by the Sudan and Zaire strains of the virus, both in terms of duration and case fatality ratio (Sudan strain 74.5 days on average and 62.7% of case fatality ratio versus Zaire strain with 150 days on average and 55.4% case fatality ratio).Conclusion:There has been a change in the epidemiological profile of the Ebola outbreaks from 1976 through 2019 with an increase in the geographical extent of the outbreaks and the population at risk, as well as a significant decrease in the outbreaks case fatality rate. There have been advances in the detection and management capacity of outbreaks, and the notification time to the WHO has been reduced. However, there are social, economic, cultural, and political obstacles that continue to greatly hinder a more efficient epidemiological approach to Ebola disease, mainly in Central Africa.
Tropical Belt Width Proportionately More Sensitive to Aerosols Than Greenhouse Gases
Authors: Zhao Xueying , Allen Robert J. , Wood Tom , Maycock Amanda C. 
Published: March 2020

AbstractThe tropical belt has widened during the last several decades, and both internal variability and anthropogenic forcings have contributed. Although greenhouse gases and stratospheric ozone depletion have been implicated as primary anthropogenic drivers of tropical expansion, the possible role of other drivers remains uncertain. Here, we analyze the tropical belt width response to idealized perturbations in multiple models. Our results show that absorbing black carbon (BC) aerosol drives tropical expansion, and scattering sulfate aerosol drives contraction. BC, especially from Asia, is more efficient per unit radiative forcing than greenhouse gases in driving tropical expansion, particularly in the Northern Hemisphere. Tropical belt expansion (contraction) is associated with an increase (decrease) in extratropical static stability induced by absorbing (scattering) aerosol. Although a formal attribution is difficult, scaling the normalized expansion rates to the historical time period suggests that BC is the largest driver of the Northern Hemisphere tropical widening but with relatively large uncertainty.