bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strike-Slip Earthquakes at the Northern Edge of the Calabrian Arc Subduction Zone
Authors: Calderoni Giovanna , Gervasi Anna , La Rocca Mario , Ventura Guido 
Published: December 2020

AbstractWe analyzed earthquakes of a swarm started in October 2019 in the Tyrrhenian Sea, at the northern border of the Calabrian arc subduction zone. The swarm is located in the same area where a subduction-transform edge propagator (STEP) shear- zone -oriented east–west is recognized from ocean floor morphology and submarine volcanoes. We computed focal mechanism, relative location, stress drop, corner frequency, and source directivity of the mainshock Mw 4.4 and of some aftershocks in the local magnitude range 2.3–3.7. Results indicate clearly that the mainshock occurred on a northwest–southeast-oriented fault, with right-lateral strike-slip motion, and it was characterized by a strong directivity of the rupture propagation from northwest to southeast. On the contrary, most of aftershocks were located on another strike-slip fault oriented northeast–southwest and had left-lateral kinematics. The kinematic features of these earthquakes indicate a strain field with the P-axis oriented north–south and the T-axis oriented east–west. Fault directions and stress field are in good agreement with the theoretical fracture model of shear zones associated with a STEP.
Universos funcionam como Grande Cérebro?
Authors: Paiva Neto Arnaldo Pinto Guedes de 
Published: December 2020

O artigo põe em debate se haveria uma forma científica de explicar a existência de Deus ou deuses. O objetivo do trabalho é responder se diferentes religiões e crenças poderiam se aliar de forma pacífica com o cientificismo. Há uma necessidade constante de diplomacia para que sobrevivamos aos sentimentos impostos pela convivência em sociedade. A nossa proposta é de sermos um movimento intelectual, bioético e científico que tente encontrar um “denominador comum” para as diferentes formas de interpretar a existência e amparar a solidão que sentimos, visto que o Universo também tem sentimentos. A visão científica deste trabalho é em defesa da existência de diversas formas de interpretar os fatos científicos e religiosos. O estudo se baseia nos princípios de liberdade religiosa e dignidade humana. A evolução da humanidade caminha lado a lado com a conciliação entre os povos e enaltecimento dos direitos humanos.
Uma Revisão Sistemática de Estudos Experimentais sobre Nomeação Bidirecional
Authors: Santos Edson Luiz Nascimento dos , Souza Carlos Barbosa Alves de 
Published: December 2020

A Nomeação bidirecional (BiN) pode ser genericamente definida como uma relação comportamental bidirecional que integra as funções verbais de falante e ouvinte. Recentemente, uma nova proposta de classificação de BiN em diferentes subtipos foi apresentada por Hawkins, Gautreaux e Chiesa (2018). O presente estudo realizou uma revisão sistemática de estudos experimentais sobre BiN com objetivo de identificar e analisar o perfil dos participantes e, considerando a nova classificação, os subtipos de BiN que os estudos buscaram avaliar e os procedimentos de ensino utilizados, os procedimentos empregados para testar a emergência da BiN, e a BiN efetivamente avaliada. Utilizando o termo ‘Naming’, foi realizada uma busca nas bases de dados PubMed, Wiley e Web of Science. Após a aplicação dos critérios de inclusão/exclusão, 29 artigos foram selecionados para análise. Observou-se que 16 estudos foram realizados com participantes com desenvolvimento atípico, e que a maioria utilizou (1) ensino de emparelhamento ao modelo por identidade com tato do estímulo modelo pelo experimentador (IDMTS+tato) e testes de tato e ouvinte na avaliação de Nomeação unidirecional de falante, considerando a análise dos efeitos do ensino de IDMTS+tato nos testes; e (2) ‘ensino por múltiplos exemplares’ (MEI) como procedimentos de indução de Nomeação unidirecional de falante. Discute-se a necessidade de estudos que avaliem de forma mais precisa os efeitos de diferentes procedimentos (ex. MEI, ‘observação de pareamento de estímulos’) na indução dos demais subtipos de BiN.Palavras-chave: nomeação bidirecional, falante, ouvinte, revisão sistemática.
The Effect of Various Milling Time Duration On The Characteristic of Glass Ionomer Cement (GIC) with The Addition of Liquid Pmve-Ma
Authors: Rudyardjo Djony Izak , Ady Jan , Fauzi Aditya Budi 
Published: December 2020

A study entitled The Effect of Milling Time Duration on the Characteristics of Glass Ionomer Cement (GIC) Dental Cement with the Addition of Liquid PMVE-MA aims to determine the effect of milling time duration on the physical and mechanical properties of Glass Ionomer Cement, and to determine the optimum milling time duration in order to obtain GIC dental cement with the best characteristic to be applied as a dental restoration material. The duration of the milling time was 80 minutes, 90 minutes, 100 minutes, and 110 minutes. After the milling process, the next process was sintered at a temperature of 1200 for 1 hour to form Powder Glass Ionomer. Then Powder Glass Ionomer was added with Poly Methyl Vinyl Ether-Maleic Acid (PMVE-MA) to form a paste. The mixed paste was then formed. Sample characterization was the density test, the compressive strength test, and the vickers hardness test. The results of the density test obtained the highest value of 1.683 gram / cm3, the compressive strength test of 71.841 MPa, and the highest value of the hardness test of 92.3 Kg / mm2. These results increased as the increasing milling time duration up to 110 minutes.
BODY IMAGE IN DIABETES MELITUS PATIENTS WITH ULCUS DIABETIC IN GRESIK
Authors: Muhalla Hafna Ilmy 
Published: December 2020

Introduction: Indonesia is ranked 4th in the world for the number of diabetics according to WHO, and most of diabetics experience complications, one of which is ulcer diabetikum. This can be a trigger for the emergence of body image disorders from diabetics, so researchers need to know the picture of ulcus sufferers' body image to later be mapped and make it easier in subsequent handling. The research objective is to describe the image of body image in patients with diabetes mellitus with ulcus complications. Physical changes in the body can affect body image and self-esteem Methods: Design of this study used a descriptive research design, the population in this study were all patients who have diabetes mellitus with ulcus diabeticum in Ibnu Sina Hospital Gresik regency with a sample of 20 respondents, samples were taken by using purposive sampling technique. Data collection using questionnaires with 15 multiple choices question. Furthermore, the data were analyzed with coding, scoring, tabulating presentatif, and described. Results: The results showed a total of 20 respondents obtained ii'om 5 respondents (25%) have a good body image, 7 respondents (35%) had a poor body image and 8 respondents (40%) who did not have a good body image. Conclusion: Based on the results of this study indicate that in patients with diabetes mellitus who are already experiencing complications of ulcus diabetic almost half of respondents do not have a good body image, and a small proportion of respondents have a good body image. This is due to several factors, namely the respondents admitted that the wounds on his legs is a sign of personal failure on him therefore to improve body image and the changing assessment of the physical condition and provide social support.
Radiofrequency Ablation for Benign Thyroid Nodules: Efficacy According to the Types of Thyroid Nodules
Authors: Li Jianhua , Xue Wenping , Xu Pengfei , Deng Zhen , Duan Caiwen , Zhang Danhua , Zheng Shouhua , Cui Kefei , Qiu Xinguang 
Published: December 2020

Abstract
Percutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 226 ones with solid nodules and 865 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.
An editable shape-memory transparent wood for smart building materials
Authors: Wang Kaili , Liu Xiaorong , Dong Youming , Ling Zhe , Li Jianzhang 
Published: December 2020

Abstract
Transparent wood (TW) with excellent optical and thermal management performance has been developed recently as a promising energy-efficient building material. Here, an editable shape-memory TW (ESMTW) is developed through in situ polymerization of epoxy vitrimers into a delignified wood scaffold. The ESMTW possesses high strength at low temperature and flexibility at high temperature, while it exhibits excellent shape-manipulation capability under thermal-stimulus. Meanwhile, the ESMTW shows unique light guiding and directional scattering effects. The light illuminance difference observed in our house model with a common glass ceiling is 81 times, whereas it is only 16 times with a ceiling made of the ESMTW. Most importantly, the transmitted light intensity distribution is tunable owing to its shape-management capability. Additionally, the resultant TW possesses great thermal insulation properties, mechanical strength, and high impact absorption ability. The combination of characteristics enables TW to exhibit great promise as an advanced functional and intelligent building material.
Salmonella Typhimurium L Forms Induce Vascular Endothelial Cell Apoptosis via Mitochondrial-Dependent Pathway
Authors: Zhai Jinhai , Zhang Tao , Yang Cuiping , Chen Dengyu 
Published: December 2020

Abstract
Background Salmonella typhimurium is a pathogenic gram-negative bacterium, which is found primarily in the intestinal lumen. It often causes diarrhea in infants and young children and leads to food poisoning, as well as septicemia and septic shock. In this study, we investigated the phenomenon and mechanism of vascular endothelial cells apoptosis induced by Salmonella typhimurium L forms, in order to recognize and control Salmonella typhimurium L-form infection.Methods The apoptosis of vascular endothelial cells at 8 hours after infection with Salmonella typhimurium L forms was determined by flow cytometric assay and fluoroscopy of Annexin V-FITC/PI staining. Caspase-9 was detected by spectrophotometer. Results Salmonella typhimurium L forms can induce apoptosis of vascular endothelial cells, with significant difference in the apoptosis rate compared with the control. Caspase-9 expression is higher than that of the control. Conclusion The ability to induce cell apoptosis of vascular endothelial cells by Salmonella typhimurium L forms may be related to mitochondria apoptosis pathway depending on Caspase-9.
&nbsp;Dental Age Estimation - Comparison of Two Established 2D Staging Techniques to Their Appliance in 3D Cone Beam Computer-Tomography
Authors: Zirk Matthias , Zoeller Joachim , Lentzen Max-Philipp , Bergeest Laura , Buller Johannes , Zinser Max 
Published: December 2020

Abstract
For medicolegal purposes, orthodontic or orthognathic treatment various stomatological staging technique for age estimation with appliance of conventional radiographic images have been published. It remains uninvestigated if cone beam computer-tomography delivers comparable staging results to the conventional radiographic stages of third molar analysis.We conducted a retrospective cross-sectional study of 312 patients aged 13 to 21 years. Dental age estimation staging technique, introduced by Nolla and Demirjian, were applied on the left lower third molar imaged by conventional panoramic radiographs and cone beam computer-tomography. It was investigated if 2D and 3D imaging presented different staging results for dental age estimation.In 21% the Demirjian’s staging differed by a single stage between 2D and 3D images. The greatest congruence (87%) between 2D and 3D images was revealed for stage 7 (G). In contrary, stage 5 (E) presented the lowest level of congruence with 47.4%. The categorization of Nolla revealed divergences in staging for than 2 categorical variables in Nolla’s stages 3,4,5 and 6. In general, the analysis of the data displayed the divergence for Nolla’s stages 4 to 8. The staging results for 2D and 3D imaging in accordance to the rules of Nolla and Demirjian showed significant differences. Individuals of 18 years may present immature third molars, thus merely an immature third molar cannot reject legal majority.Nolla’s and Demirjian’s 2D and 3D imaging present significantly different staging results.
ZNF213 Facilitates ER Alpha Signaling in Breast Cancer Cells
Authors: Yang Huijie , Lv Xulei , Li Xin , Mao Lanzhi , Niu Zhiguo , Wang Ting , Zhuang Ting , Huang Qingsong 
Published: December 2020

Abstract
Background Breast cancer is the most common women malignancy worldwide, while estrogen receptor alpha positive type accounts for two third of all breast cancers. Although ER alpha positive breast cancer could be effectively controlled by endocrine therapy, more than half of the cases could develop endocrine resistance, making it an important clinical issue in breast cancer treatment. Thus, decoding the detailed mechanism, which controls ER alpha signaling activation and ER alpha protein stability, is of great importance for the improvement of breast cancer therapy. Methods CCK8 and Edu assay was used to measure cell proliferation. RNA sequence was performed by Ingenuity pathway analysis. The ER alpha signaling activities were measured with luciferase assay, QPCR and western blotting. Protein stability assay and ubiquitin assay were used to determine ER alpha protein degradation and ubiquitination. The immuno-precipitation was utilized to determine ER alpha and ZNF213 interaction. The ubiquitin-based immuno-precipitation assay was sued to detect specific ubiquitination manner on ER alpha. Results we identified ZNF213 as a novel zinc finger protein, which modulated ER alpha protein. ZNF213 expression correlated with poor outcome in endocrine treated patients. ZNF213 depletion inhibited ER alpha signaling and proliferation in breast cancer cells. Further mechanistic studies showed ZNF213 located in cytosol and nuclear, which modulated ER alpha stability via inhibiting ER alpha K48-linked ubiquitination. Conclusions Our study reveals an interesting post-translational mechanism between ER alpha and ZNF213 in breast cancer. Targeting ZNF213 could be an appealing strategy for ER alpha positive breast cancer.
Trends of delayed first antenatal care visit among pregnant women in Ethiopia based on the EDHS 2000-2016 data: Multivariate decomposition analysis
Authors: Gebeyehu Asaye , Muche Achenef , Merid Mehari 
Published: December 2020

Abstract
Background: Timing of first antenatal care visiting is crucial for women and fetus health. However, most of the women had delayed antenatal care visits and lacked early detection of existing complications. Hence, this study aimed to assess the trends and magnitude of delayed first antenatal care visits among pregnant women in Ethiopia.Method: This study used cross-sectional data analysis on Ethiopian Demographic and Health Surveys. A total weighted sample of 2146 in 2000, 2051 in 2005, 3368 in 2011, and 4740 in 2016 women who received at least one antenatal care visit in the past five years before each survey were included. Stata 14.1 software was used for data management and further analysis. Trends and multivariate logistic decomposition analyses were employed to examine the change in delayed first antenatal care visits with sampling weighting for the survey data. The 95% confidence interval was used for considering statistical significance.Results: The proportion of delayed first antenatal care visit was declined from 76.8 (95%CI: 75.1−78.6) in 2000 to 67.3 (95%CI: 65.9−68.6) in 2016. The decomposition analysis showed that 39% of the overall change in delayed first antenatal care visit over time was due to differences in characteristics whereas about 61% was due to the effect of characteristics. The significant contributing factors for the decline of delayed first antenatal care visit were the place of residence, husband’s education, women occupation, told about pregnancy complications, caesarean delivery, and family size. Conclusion: The proportion of delayed first antenatal care visits has been declined over time in Ethiopia, but still it remains high. More of the overall change in delayed first antenatal care visit was attributed to a change in health behavior among pregnant women. Public health interventions or programs such as health education and behavioral change communication targeting the rural residents, lower economic status, and family size would be suggested to decline delayed first antenatal care visit.
Functional Stability: An Experimental Knee Joint Cadaveric Study on Collateral Ligaments Tension
Authors: Innocenti Bernardo , Bori Edoardo , Paszicsnyek Thomas 
Published: December 2020

Abstract
Introduction Applying proper tension to ligaments during Total-Knee-Arthroplasty surgery is fundamental for optimal implant performance: low tensions lead to joint instability, over-tensioning to pain and stiffness. “Functional stability” must then be defined and achieved. An experimental cadaveric activity was performed to measure the minimum tension required to achieve this stability. Methods Ten knee specimens were investigated; femur and tibia were clamped to a loading-frame; constant displacement rate was applied and resulting tension force was measured. Joint stability was determined as the slope change in the force/displacement curve, representing the ligaments’ elastic-region activation; the tension required to reach functional stability is the span between ligaments toe-region and this point. Intact, ACL(Anterior-Cruciate-Ligament)-resected and ACL&PCL(Posterior-Cruciate-Ligament)-resected knees were tested. Different flexion angles were tested. Results Results demonstrated an overall tension of 40-50N to be enough to reach stability in intact knees. Similar values are sufficient in ACL-resected knees; higher tension is required (up to 60N) after ACL&PCL resection; slightly higher values were found for 60° flexion. Results agree with other experimental studies, showing that the tensions required to stabilize the joint are lower than the ones currently applied via surgical tensioners. Conclusion To reach functional stability, surgeons should consider such results intraoperatively to avoid ligament laxity or over-tensioning.
Plastic contamination of the Galapagos marine food web and the relative risks to native species
Authors: Jones Jen , Porter Adam , Muñoz-Pérez Juan , Alarcón-Ruales Daniela , Galloway Tamara , Godley Brendan , Santillo David , Vagg Jessica , Lewis Ceri 
Published: December 2020

Abstract
Ecuador’s Galapagos Islands and their unique biodiversity are a global conservation priority. We investigated the presence, partitioning and environmental drivers of plastic contamination across the marine ecosystem, designing a systematic risk scoring analysis to identify the most vulnerable species. Beach contamination varied by site (macroplastic 0 - 0.66 items.m-2, large microplastics 0 - 448.8 particles.m-2, small microplastics 0 – 74.6 particles.kg-1), with high plastic accumulation on east-facing beaches indicating input from the Humboldt Current. Local littering and waste management leakages accounted for 2% of macroplastic. Microplastics (including synthetic cellulosics) were prevalent in sediments (6.7 - 86.7 particles.kg-1) and surface seawater (0.04 - 0.89 particles.m-3), with elevated concentrations in the harbour suggesting local input. Microplastics were present in all seven marine invertebrate species examined, found in 52% of individuals (n = 123). Risk scoring identified 32 species in need of urgent, targeted monitoring and mitigation including pinnipeds, seabirds, turtles, sharks and corals.
Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism
Authors: Lim Elaine , Chan Yingleong , Burns Mannix , Guo Xiaoge , Erdin Serkan , Tai Derek , Reichert Julia , Chan Ying Kai , Chiang Jessica , Meyer Katharina , Zhang Xiaochang , Walsh Christopher , Yankner Bruce , Raychaudhuri Soumya , Hirschhorn Joel , Gusella James , Talkowski Michael , Church George 
Published: December 2020

Abstract
Human-derived cerebral organoids demonstrate great promise for identifying cell types and cell type specific molecular processes perturbed by genetic variants associated with neuropsychiatric and neurodevelopmental disorders, which are notoriously challenging to study using animal models. However, considerable challenges remain in achieving robust, scalable and generalizable phenotyping of organoids to discover cell types and cell type specific genes. We perform RNA sequencing on 71 samples comprising 1,420 cerebral organoids from 25 donors, and describe a framework (Orgo-Seq) to integrate bulk RNA and single-cell RNA sequence data from human post-mortem brains and cerebral organoids, for the identification of cell types and cell type specific individual genes. We apply Orgo-Seq for two autism-associated loci: 16p11.2 deletions and 15q11-13 duplications, and identify neuroepithelial cells as critical cell types for 16p11.2 deletions, and discover novel and previously reported cell type specific driver genes. Finally, we validated our results that mutations in the KCTD13 gene in the 16p11.2 locus lead to imbalances in the proportion of neuroepithelial cells, using CRISPR/Cas9-edited mosaic organoids. Our work presents a quantitative technological framework to integrate multiple transcriptomics datasets to identify cell types and cell type specific driver genes associated with complex diseases using cerebral organoids.