bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoliposome Precursors for Shape Modulation: Use of Heuristic Algorithm and QBD Principles for Encapsulating Phytochemicals
Authors: Nadaf Sameer J. , Killedar Suresh G. 
Published: May 2020

Background:
Screening of multiple methods is worthless for formulators due to material
losses, wastage of time, and expenditures. It is imperative to make a quick decision.

Objective:
The present investigation describes the systematic approach to select the best suitable method
for the development of nanoliposomes (NL), the precursor of nanocochleates encapsulating curcumin
using Analytic Hierarchy Process (AHP).

Methods:
Pair-wise comparison matrices were used to achieve the overall priority weight and ranking
for the selection of appropriate technique. Furthermore, Plackett-Burman screening Design (PBD) was
exploited to investigate specific effects of associated formulation and process variables on particle size
(Y1), drug content (Y2), and entrapment efficiency (Y3), while fabricating NL.

Results:
Results revealed the reliability of the pair-wise comparison matrices and selected the ethanol
injection method with the highest priority weight (0.337). Bland-Altman plot and control chart validated
the results of AHP. The preparation of vesicles with the preferred diameter and size distribution was
essentially fulfilled. Stirring speed (X5), amount of phospholipid (X4), and cholesterol (X8) showed
significant influence (p<0.05) on Y1 and Y3, PBD revealed. These factors can be further optimized
using the design of experiments.

Conclusion:
AHP being an effective tool, has assisted in selecting the best alternative for fabricating
NL, whilst PBD enabled a clear understanding of the effects of diverse formulation variables on
responses studied. Results ensure that NL is a riveting candidate for modulating effectively into tailormade
diverse shaped nanoformulations for further in vitro and in vivo studies.
Evaluating the Effect of Integra Seeded with Adipose Tissue-Derived Stem Cells or Fibroblasts in Wound Healing
Authors: Wang Yuchang , Feng Quanrui , Li Zhanfei , Bai Xiangjun , Wu Yiping , Liu Yukun 
Published: May 2020

Background:
Extensive loss of skin in burn patients can have devastating consequences,
both physically and mentally. Adipose-Derived Stem Cells (ADSCs) and fibroblasts are known to play
significant roles in the process of wound healing. Recently, bioengineered skin has been considered for
wound healing purposes.

Methods:
Investigate the effect of Integra seeded with ADSCs, fibroblasts, or both on wound healing.

Results:
We found that when Integra is seeded with ADSCs and fibroblasts, both types of cells incorporate
and proliferate, the phenomenon becoming more robust when the cells are co-cultured on Integra,
both in vitro and in vivo. In addition, when these cells are seeded on Integra, they stimulate epithelization
with no signs of inflammation and skin necrosis being observed when transplanted on animals for 7 days.

Conclusion:
ADSCs and fibroblasts seeded on Integra could decrease the number of α-SMA positive
myofibroblasts, leading to scarless wound healing. The evidence from this study is strongly supportive
that Integra seeded with ADSCs and fibroblasts is an appropriate and effective bioengineered skin for
wound healing.
Green Synthesis of Substituted Dihydropyrimidin-2(1H)-one by Using Zinc Chloride /Acetic Acid Catalytic System
Authors: Thorat Bapu R. , Gurav Ankita , Dalvi Bharat , Sawant Ashwini , Lokhande Vikas , Mali Suraj N. 
Published: May 2020

Background:
Biginelli reaction is the most well-known and widely studied, multicomponent
reaction used for the direct synthesis of many biologically active 3,4-dihydropyrimidin-
2(1H)-ones and their derivatives by reacting a β-keto ester/1,3-dicarbonyl compound, an aldehyde,
and urea. It is catalyzed by different Bronsted and Lewis acids.

Methods:
The catalytic effect of different metal chlorides, such as sodium, potassium, magnesium,
stannous, ferric, manganese, cupric, nickel, cobalt, and zinc, in absence and presence of acetic acid
were studied.

Results:
The zinc, ferric, cupric, and cobalt chlorides were found to be more effective catalysts for
Biginelli reaction at room temperature. The yield of the reaction increased with temperature for all
catalytic systems. Acetophenone, cyclohexanone, acetyl acetone, and different β-ketoesters formed
tetrahedropyrimidine in moderate to good yield, by using zinc chloride catalyst at room
temperature in acetic acid. The efficiency of the catalyst was studied by treating different
substituted aldehydes with 1,3-dicarbonyl compounds and urea at room temperature.

Conclusion:
The zinc chloride in acetic acid found to be an effective greener catalyst system for
Biginelli reaction.
Measures Undertaken in China to Avoid COVID-19 Infection: Internet-Based, Cross-Sectional Survey Study
Authors: Huang Yu , Wu Qingqing , Wang Ping , Xu Yan , Wang Lei , Zhao Yusui , Yao Dingming , Xu Yue , Lv Qiaohong , Xu Shuiyang 
Published: May 2020

BackgroundIn early 2020, over 80,000 cases of coronavirus disease (COVID-19) were confirmed in China. Public prevention and control measures, along with efforts from all sectors of society, were undertaken to control and eliminate disease transmission.ObjectiveThis paper describes Chinese citizens’ response to the epidemic, the preventive measures they implemented to avoid being infected, and the public strategies that were carried out by the government, health workers, etc. We also discuss the efficacy of these measures in controlling the epidemic in China.MethodsInformation on the responses and behaviors of Chinese citizens were collected through a cross-sectional, internet-based survey using Dingxiang Doctor’s public account on WeChat. Information on public strategies implemented by all sectors of society to control the epidemic and data on new COVID-19 cases were collected from the internet, mainly from government websites. Standard descriptive statistics and multivariate logistic regression analyses were conducted to analyze the data.ResultsA total of 10,304 participants responded to the survey, with 10,198 valid responses; 74.1% (n=7557) were female and 25.9% (n=2641) were male. Overall, 98.2% (n=10,013) of participants paid high or very high attention to the epidemic, with WeChat being their main information source (n=9400, 92.2%). Over half the participants (n=5878, 57.7%) were confident that the epidemic could be curbed in China; 92.4% (n=9427) opened windows for ventilation more frequently than usual; 97.9% (n=9986) used masks in public; 95.7% (n=9759) avoided large crowds and stayed at home as much as possible; and 97.9% (n=9988) washed their hands more often than usual. Women were more likely to practice these behaviors than men (P<.001). With a series of strict public control measures, like nationwide health education campaigns, holiday extensions, the Examine and Approve Policy on the resumption of work, close management of working and living quarters, a health QR (Quick Response) code system, community screening, and social distancing policies, the number of new cases have decreased dramatically since February 12, 2020.ConclusionsThe methods employed by Chinese citizens and authorities have effectively curtailed the spread of COVID-19, demonstrating that this pandemic can be brought under control as long as the right measures are taken.
Actitudes proambientales en jóvenes universitarios
Authors: Cantú-Martínez Pedro César 
Published: May 2020

El presente trabajo tiene por objetivo conocer las actitudes hacia el ambiente de estudiantes universitarios que previamente cursaron una materia de ecología y biodiversidad. Se realizó en la Universidad Autónoma de Nuevo León, México, con una muestra de 52 estudiantes de ambos sexos, a través de un Cuestionario de Actitudes Ambientales. El 84.6 % mostró buena actitud y 15.4 % moderada actitud proambiental. Tres consideraciones presentaron mayor frecuencia en su mención: (a) que el gobierno ejerza mayores medidas para prevenir la contaminación, (b) que el gobierno proporcione una lista de dependencias para denunciar las quejas sobre contaminación y (c) que las escuelas deben impartir cursos de conservación de recursos naturales. Se concluye que los y las estudiantes cuentan con un comportamiento ambientalmente significativo; y que además no existe diferencia según sexo.
Implementasi Algoritma Analitycal Hierarchy Process (AHP) pada Aplikasi Pengambilan Keputusan Penilaian Karyawan Berbasis Web pada PT XYZ
Authors: Felinda Amelia 
Published: May 2020

Perkembangan teknologi informasi di masa sekarang ini berkembang dengan cepat . Sistem yang dijalankan dengan konvensional sudah tidak efektif lagi diterapkan . Pemanfaatan teknologi informasi merupakan suatu kebutuhan yang harus diterapkan oleh suatu organisasi untuk menghasilkan sistem yang efektif dan efisien . PT xyz merupakan perusahaan yang bergerak di bidang otomotif dimana pada setiap akhir tahun , perusahaan melakukan penilaian terhadap kinerja karyawannya . Penilaian dilakukan sebagai dasar perusahaan dalam memberikan apresiasi . Selain itu, penilaian juga dipakai sebagai nilai acuan untuk kenaikan golongan dan kenaikan jabatan karyawan . Pada prakteknya, penilaian dilakukan dengan kurang transparan, dimana yang terjadi atasan memberikan nilai tidak berdasarkan kriteria maupun data , tetapi yang dilakukan hanya berdasarkan pengamatan yang dilakukan pada menjelang akhir tahun saja tanpa adanya data keseluruhan sesuai kriteria penilaian . Berdasarkan masalah tersebut , maka dirancanglah suatu aplikasi berbasis web menggunakan algoritma Analitycal Hierarchy Process (AHP) sebagai metode pengambilan keputusan dalam penilaian karyawan . Metode pengembangan sistem menggunakan software development life cycle ( SDLC ) . Aplikasi ini dikembangkan dengan php dan data base my sql .
Soft Approach cons radicalization as an attempt to deradicalize through Islam Nusantara approach
Authors: Muridan Muridan 
Published: May 2020

ABSTRACT

Radicalism has become a concern for the Indonesian people, cause its practice reduce diversity and peace. The emergence of radicalism in Indonesia is caused by four main factors, namely political violence, poor governance, global revival, and the spirit of Arabism. Radicalism also arises as a result of deviations from religious norms, as well as secular life in people's lives.
Radicalism in Indonesia is increasingly developing along with the development of formalistic and rigid understanding of religion in understanding the texts of the study of religion. only textually, not seeing from other factors, so the actions they taken only refer to the behavior of the Prophet literally.
Efforts to suppress the development of radicalism (radicalism) of the government have made various efforts, both soft approaches and hard approaches. The aim is to safeguard the Pancasila and Unity in Diversity which aspire to unity, unity and positive cooperation in building the nation and state. The government also encourages every element of society to actively participate in suppressing the development of radicalism.
Nahdlatul Ulama as the largest Islamic Community Organization (ORMAS) in Indonesia, called and participated in deradicalization, by offering an Islamic approach called as Islam Nusantara. Islam Nusantara is a ideology of Islam that is not only textual but also contextual and respects local wisdom. Islam Nusantara offers a moderate (moderate) Islam that is not extreme, always balanced and inclusive, tolerant and can coexist peacefully with followers of other religions, and can accept democracy.
The model of Islam Nusantara approach is actually not only aimed at those who have been contaminated by radical understanding, but also the general public as a preventive effort, so that they are not contaminated by radicalism.

Keyword: Radicalism, Deradicalization, Islam Nusantara,
Pañuelazos por el aborto legal, seguro y gratuito
Authors: Presman Clara 
Published: May 2020

En el presente artículo la autora indaga sobre los cruces entre estética y política, sus conjunciones y sus desvíos como territorios fértiles desde donde pensar la cultura y las sociedades contemporáneas. A partir de afirmar que las políticas visuales de los movimientos sociales se han apropiado de la calle con gran fuerza, se abordan las intervenciones artísticas que devinieron de los llamados pañuelazos, durante la coyuntura política de 2018 en la Argentina, en el marco de la lucha por la legalización y la despenalización del aborto.
PENERAPAN SEDERHANA VIRTUAL REALITY DALAM PRESENTASI ARSITEKTUR
Authors: Syafril Red Savitra 
Published: May 2020

Presentasi dalam arsitektur memiliki perkembangan dari masa ke masa. Dari awalnya menggunakan gambar tangan beralih menggunakan visual yang diciptakan oleh komputer. Semakin berkembangnya teknologi, semakin menarik presentasi yang dihasilkan. Hasil presentasi juga semakin nyata, sehingga mendekati objek rancangan aslinya. Perkembangan teknologi semakin maju, penggunaan teknologi Virtual Reality banyak digunakan hampir di semua bidang, tidak luput di bidang Arsitektur. Dalam Arsitektur, penggunaan Virtual Reality sebagai alat presentasi sudah cukup banyak dilakukan. Namun, metode yang diterapkan membutuhkan biaya yang cukup besar dan masih terlalu rumit untuk di aplikasikan. Penelitian ini menemukan penerapan Virtual Reality secara sederhana dan dapat diterapkan secara umum maupun praktisi arsitektur. Metode yang digunakan yaitu simulasi dengan beberapa perangkat yang pendukung. Kesimpulan dalam penelitian ini menunjukkan bahwa, Virtual Reality dapat diterapkan dengan penerapan sederhana.Kata kunci: Penerapan Sederhana, Virtual Reality, Presentasi Arsitektur
Numerical simulation and feasibility assessment of acid gas injection in a carbonate formation of the Tarim Basin, China
Authors: Zhang Xiaoyan , Li Qi , Zheng Liange , Li Xiaying , Xu Liang 
Published: May 2020

An enormous amount of acid gas, containing carbon dioxide (CO2) and hydrogen sulfide (H2S), is generated in the exploitation of oil and gas reservoirs in the Tarim Basin, China. An appropriate management plan is required to safely dispose of the acid gas, and common strategy considered for the safe disposal of acid gas is the injection of it into deep formations – this strategy mitigates greenhouse gas emissions and avoids costs associated with desulfurization. A feasibility assessment of acid gas injection requires a detailed investigation of the potential physical and geochemical impacts. Reactive transport simulations based on the mineralogical composition and the hydrochemical characteristics of a carbonate formation in the Tarim Basin were conducted to identify the physical and geochemical interactions of acid gas with the mineral matrix and formation water. Acid gas (59% CO2 and 41% H2S) was injected at a constant rate of 19 200 Nm3/d for 25 years, and the simulation was run by the TMVR_EOSG module of the TOUGHREACT code for a period of 10 000 years. The results indicate that the minimum liquid saturation is much larger than the residual water saturation, and the pressure buildup is below the allowable pressure increase. Additionally, the porosity change is found to be negligible due to the small changes in calcite and quartz in the volume fraction. From this perspective, acid gas injection in the carbonate formation of the Tarim Basin seems feasible. Furthermore, the fast breakthrough of CO2 can provide an advanced warning of a potential breakthrough of acid gas. Last, the injection rate can be increased to accelerate acid gas trapping, and the results could be used as guidance for future acid gas injection operations.
The value and practical utility of intraoperative touch imprint cytology of sentinel lymph node(s) in patients with breast cancer: A retrospective cytology-histology correlation study
Authors: Uno Yuji , Akiyama Naoko , Yuzawa Sayaka , Kitada Masahiro , Takei Hidehiro 
Published: May 2020

Objective:
Intraoperative evaluation of sentinel lymph nodes (SLNs) for patients with breast cancer is widely performed with frozen section (FS), cytology, or a combination of both. Touch imprint cytology (TIC) reportedly has an equivalent sensitivity to FS. We studied its diagnostic utility to detect SLN metastases.

Materials and Methods:
Cases of 367 patients with breast cancer who underwent intraoperative valuation of SLNs (507 LNs) were evaluated. All FS and corresponding TIC slides of SLNs of each case were reviewed microscopically for the presence of metastases of any size. If present, the metastatic focus was measured on the FS.

Results:
Of these 507 SLNs, 82 LNs (16.2%) from 69 women were found to have metastases in the FS and consisted of 5 LNs of isolated tumor cells, 15 of micrometastasis, and 62 of macrometastasis. TIC identified metastases in 69 of these 82 SLNs (sensitivity: 84.1%, specificity: 100%, and accuracy: 97.4%). All macrometastases could be detected by TIC, whereas TIC identified approximately 50% of micrometastases and none of isolated tumor cells. The size detection limit of metastatic foci, defined as the smallest dimension of metastasis detected without false negatives, was 2 mm. The smallest metastatic focus identified was 0.8 mm.

Conclusions:
TIC of SLNs is of great use given its negative predictive value of 100% for identification of macrometastasis in our study. For intraoperative evaluation of SLNs, based on our data, a practical two-step approach is proposed: SLN evaluation should be initially performed by TIC and then proceed to FS histological analysis only when cytologically positive to determine the size of metastatic focus.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) TERHADAP KEMAMPUAN SISWA MENULIS KREATIF PUISI BERKENAAN DENGAN PERISTIWA YANG DIALAMI SISWA KELAS VII MTS. PATRA MANDIRI PLAJU
Authors: Wahyuni Tuti Sri 
Published: May 2020

Rumusan masalah dalam penelitian ini adalah bagaimanakah pengaruh model pembelajaran kooperatif tipe CIRC terhadap kemampuan siswa menulis kreatif puisi berkenaan dengan peristiwa yang dialami siswa kelas VII MTs. Patra Mandiri Plaju. Tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan pengaruh model pembelajaran kooperatif tipe CIRC terhadap kemampuan siswa menulis kreatif puisi berkenaan dengan peristiwa yang dialami siswa kelas VII MTs. Patra Mandiri Plaju. Metode yang digunakan dalam penelitian iniÂ yaitu metode eksperimen dan teknik pengumpulan data dilakukan dengan teknik tes yaitu menulis puisi berdasarkan peristiwa yang pernah dialami/pengalaman pribadi siswa, teknik wawancara dan teknik dokumentasi. Â Hasil penelitian menunjukkan bahwa model pembelajaran kooperatif tipe CIRC berpengaruh positif terhadap kemampuan siswa menulis kreatif puisi berkenaan dengan peristiwa yang dialami pada siswa kelas VII MTs.Patra Mandiri Plaju. Hal ini dapat dilihat dari nilai rata-rata pre-testÂ sebesar 73,38 sedangkan nilai rata-rata post-test sebesar 83.16 tergolong sangat baik, sedangkan nilai rata-rata pre-test kelas kontrol sebesar 64,97 dan nilai post-test kelas kontrol sebesar 71,94 tergolong kurang baik. Hal ini juga dapat dibuktikan bahwa hasil uji hipotesis thitungÂ = 6,6 > ttabel = 1,667 maka Ho ditolak dan Ha diterima.Kata Kunci: model pembelajaran kooperatif tipe CIRC, menulis kreatif, puisi
Biogeochemical assessment of soils and plants in industrial, residential and recreational areas of Saint Petersburg
Authors: Pashkevich M. , Bech J. , Matveeva V. , Alekseenko A. 
Published: May 2020

Soils and plants of Saint Petersburg are under the constant technogenic stress caused by human activity in industrial, residential, and recreational landscapes of the city. To assess the transformed landscapes of various functional zones, we studied utility, housing, and park districts with a total area of over 7,000 hectares in the southern part of the city during the summer seasons of 2016-2018. Throughout the fieldwork period, 796 individual pairs of soil and plant samples were collected.A complex of consequent laboratory studies performed in an accredited laboratory allowed the characterization of key biogeochemical patterns of urban regolith specimens and herbage samples of various grasses. Chemical analyses provided information on the concentrations of polluting metals in soils and plants of different land use zones.Data interpretation and calculation of element accumulation factors revealed areas with the most unfavorable environmental conditions. We believe that a high pollution level in southern city districts has led to a significant degree of physical, chemical, and biological degradation of the soil and vegetation cover. As of today, approximately 10 % of the Technosols in the study area have completely lost the ability to biological self-revitalization, which results in ecosystem malfunction and the urgent need for land remediation.
Influence of parameters of delayed asphalt coking process on yield and quality of liquid and solid-phase products
Authors: Kondrasheva N. , Rudko V. , Nazarenko M. , Gabdulkhakov R. 
Published: May 2020

Paper studies the effect of excess pressure during delayed coking of asphalt, obtained by propane deasphaltization of tar, on yield and physical and chemical properties of hydrocarbon fuels' components and solid-phase product – petroleum coke. Asphalt was coked at a temperature of 500 °C and excess pressure of 0.15-0.35 MPa in a laboratory unit for delayed coking of periodic action. Physical and chemical properties of raw materials and components of light (gasoline), medium (light gasoil), and heavy (heavy gasoil) distillates obtained during experimental study were determined: density, viscosity, coking ability, sulfur content, iodine number, pour points, flash points, fluidity loss and fractional composition. Quantitative group hydrocarbon and microelement compositions and properties of obtained samples of petroleum coke (humidity, ash content, volatiles' yield, sulfur content, etc.) were also studied. Comparative assessment of their quality is given in accordance with requirements of GOST 22898-78 “Low-sulfur petroleum coke. Specifications”. In addition, patterns of changes in excess coking pressure on yield and quality indicators of distillate products and petroleum coke were revealed. With an increase in excess pressure of coking process from 0.15 to 0.35 MPa, content of paraffin-naphthenic hydrocarbons in light and heavy gasoils of delayed coking decreases. Common pattern in asphalt coking is an increase in yield of coke and hydrocarbon gas with an increase in excess pressure from 0.15 to 0.35 MPa.