bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated delivery of chlorhexidine chips for the treatment of peri‐implantitis: A multicenter, randomized, comparative clinical trial
Authors: Machtei Eli E. , Romanos Georgios , Kang Philip , Travan Suncica , Schmidt Stephan , Papathanasiou Evangelos , Tatarakis Nikolaos , Tandlich Moshik , Liberman Leila H. , Horwitz Jacob , Bassir Seyed Hossein , Myneni Srinivas , Shiau Harlan J. , Shapira Lior , Donos Nikos , Papas Athena , Meyle Joerg , Giannobile William V. , Papapanou Panos N. , Kim David M. 
Published: October 2020

AbstractBackgroundPeri‐implantitis is a challenging condition to manage and is frequently treated using non‐surgical debridement. The local delivery of antimicrobial agents has demonstrated benefit in mild to moderate cases of peri‐implantitis. This study compared the safety and efficacy of chlorhexidine gluconate 2.5 mg chip (CHX chips) as an adjunctive treatment to subgingival debridement in patients afflicted with peri‐implantitis.MethodsA multicenter, randomized, single‐blind, two‐arm, parallel Phase‐3 study was conducted. Peri‐implantitis patients with implant pocket depths (IPD) of 5‐8 mm underwent subgingival implant surface debridement followed by repeated bi‐weekly supragingival plaque removal and chlorhexidine chips application (ChxC group) for 12 weeks, or similar therapy but without application of ChxC (control group). All patients were followed for 24 weeks. Plaque and gingival indices were measured at every visit whereas IPD, recession, and bleeding on probing were assessed at 8, 12, 16, 24 week.ResultsA total of 290 patients were included: 146 in the ChxC group and 144 in the control. At 24 weeks, a significant reduction in IPD (P = 0.01) was measured in the ChxC group (1.76 ± 1.13 mm) compared with the control group (1.54 ± 1.13 mm). IPD reduction of ≥2 mm was found in 59% and 47.2% of the implants in the ChxC and control groups, respectively (P = 0.03). Changes in gingival recession (0.29 ± 0.68 mm versus 0.15 ± 0.55 mm, P = 0.015) and relative attachment gain (1.47 ± 1.32 mm and 1.39 ± 1.27 mm, P = 0.0017) were significantly larger in the ChxC group. Patients in the ChxC group that were < 65 years exhibited significantly better responses (P < 0.02); likewise, non‐smokers had similarly better response (P < 0.02). Both protocols were well tolerated, and no severe treatment‐related adverse events were recorded throughout the study.ConclusionsPatients with peri‐implantitis that were treated with an intensive treatment protocol of bi‐weekly supragingival plaque removal and local application of chlorhexidine chips had greater mean IPD reduction and greater percentile of sites with IPD reduction of ≥2 mm as compared with bi‐weekly supra‐gingival plaque removal.
Dramatic Changes in Oncology Care Pathways During the COVID-19 Pandemic: The French ONCOCARE-COV Study
Authors: Brugel Mathias , Carlier Claire , Essner Christine , Debreuve-Theresette Adeline , Beck Marie-Françoise , Merrouche Yacine , Bouché Olivier 
Published: October 2020

Abstract
The coronavirus disease 2019 (COVID-19) pandemic may have affected cancer management. We aimed to evaluate changes in every oncology care pathway essential step, from screening to treatment, during the pandemic.
Monthly oncological activity differences between 2019 and 2020 (screening tests, histopathological analyzes, multidisciplinary tumor board meetings (MTBMs), diagnostic announcement procedures (DAPs), and treatments were calculated in two French areas experiencing different pandemic intensity (Reims and Colmar).
COVID-19 has had a dramatic impact in terms of screening (−86% to −100%), diagnosis (−39%), and surgical treatment (−30%). This global decrease in all essential oncology care pathway steps contrasted with the relative stability of chemotherapy (−9%) and radiotherapy use (−16%). Outbreak occurred earlier and with more intensity in Colmar but had a comparable impact in both areas regarding MTMBs and DAPs.
The current ONCOCARE-COV study is still in progress and with a longer follow-up to analyze postlockdown situation.
Digital anthropometry for body circumference measurements: Toward the development of universal three‐dimensional optical system analysis software
Authors: Sobhiyeh Sima , Kennedy Samantha , Dunkel Alexander , Dechenaud Marcelline E. , Weston Jerome A. , Shepherd John , Wolenski Peter , Heymsfield Steven B. 
Published: October 2020

AbstractBackground/ObjectiveDigital anthropometric (DA) assessments are increasingly being administered with three‐dimensional (3D) optical devices in clinical settings that manage patients with obesity and related metabolic disorders. However, anatomic measurement sites are not standardized across manufacturers, precluding use of published reference values and pooling of data across research centers.Subjects/MethodsThis study aimed to develop universal 3D analysis software by applying novel programming strategies capable of producing device‐independent DA estimates that agree with conventional anthropometric (CA) measurements made at well‐defined anatomic sites. A series of technical issues related to proprietary methods of 3D geometrical reconstruction and image analysis were addressed in developing major software components. To evaluate software accuracy, comparisons were made to CA circumference measurements made with a flexible tape at eleven standard anatomic sites in up to 35 adults scanned with three different commercial 3D optical devices.ResultsOverall, group mean CA and DA values across the three systems were in good agreement, with ∼2 cm systematic differences; CA and DA estimates were highly correlated (all p‐values <0.01); root‐mean square errors were low (0.51–3.27 cm); and CA‐DA bias tended to be small, but significant depending on anatomic site and device.ConclusionsAvailability of this software, with future refinements, has the potential to facilitate clinical applications and creation of large pooled uniform anthropometric databases.
Investigation of the synergy influence of KSiCB and POE‐g‐MAH on mechanical properties of basalt fiber‐reinforced PA6 composites
Authors: Yu Kaifeng , Li Zhichao , Liang Jicai , Li Yi , Liang Ce 
Published: October 2020

AbstractSilicon carbon black (SiCB), a kind of biomass carbon material, is a kind of pyrolysis ash prepared by anoxic pyrolysis of rice husk. When filled as an inorganic reinforcement in the composite material basalt fiber (BF) reinforced polyamide 6 (PA6), it has synergetic effect with the POE‐g‐MAH elastomer. Differential scanning calorimetry analysis shows that KSiCB plays a role of heterogeneous nucleation in the composite material, accelerates the nucleation and crystallization speed of PA6, and can increase the strength and rigidity of the composite material. Scanning electron microscope observation of the fracture surface of the composite material shows that the addition of KSiCB can effectively “pin” and inhibit crack propagation. When the content of KSiCB is 2.5 phr, the tensile strength of the composite material KSiCB/POE‐g‐MAH/PA6(BF) reaches a maximum of 125.194 MPa, the tensile modulus is 2791.257 MPa, the bending strength reaches 192.034 MPa, and the impact toughness reaches 23.42 kJ/m2.
Thermo‐erosional valleys in Siberian ice‐rich permafrost
Authors: Morgenstern Anne , Overduin Pier Paul , Günther Frank , Stettner Samuel , Ramage Justine , Schirrmeister Lutz , Grigoriev Mikhail N. , Grosse Guido 
Published: October 2020

AbstractThermal erosion is a major mechanism of permafrost degradation, resulting in characteristic landforms. We inventory thermo‐erosional valleys in ice‐rich coastal lowlands adjacent to the Siberian Laptev Sea based on remote sensing, Geographic Information System (GIS), and field investigations for a first regional assessment of their spatial distribution and characteristics. Three study areas with similar geological (Yedoma Ice Complex) but diverse geomorphological conditions vary in valley areal extent, incision depth, and branching geometry. The most extensive valley networks are incised deeply (up to 35 m) into the broad inclined lowland around Mamontov Klyk. The flat, low‐lying plain forming the Buor Khaya Peninsula is more degraded by thermokarst and characterized by long valleys of lower depth with short tributaries. Small, isolated Yedoma Ice Complex remnants in the Lena River Delta predominantly exhibit shorter but deep valleys. Based on these hydrographical network and topography assessments, we discuss geomorphological and hydrological connections to erosion processes. Relative catchment size along with regional slope interact with other Holocene relief‐forming processes such as thermokarst and neotectonics. Our findings suggest that thermo‐erosional valleys are prominent, hitherto overlooked permafrost degradation landforms that add to impacts on biogeochemical cycling, sediment transport, and hydrology in the degrading Siberian Yedoma Ice Complex.
Experimental validation of manipulability optimization control of a 7‐DoF serial manipulator for robot‐assisted surgery
Authors: Su Hang , Danioni Andrea , Mira Robert Mihai , Ungari Matteo , Zhou Xuanyi , Li Jiehao , Hu Yingbai , Ferrigno Giancarlo , De Momi Elena 
Published: October 2020

AbstractPurposeBoth safety and accuracy are of vital importance for surgical operation procedures. An efficient way to avoid the singularity of the surgical robot concerning safety issues is to maximize its manipulability in robot‐assisted surgery. The goal of this work was to validate a dynamic neural network optimization method for manipulability optimization control of a 7‐degree of freedom (DoF) robot in a surgical operation.MethodsThree different paths, a circle, a sinusoid and a spiral were chosen to simulate typical surgical tasks. The dynamic neural network‐based manipulability optimization control was implemented on a 7‐DoF robot manipulator. During the surgical operation procedures, the manipulability of the robot manipulator and the accuracy of the surgical operation are recorded for performance validation.ResultsBy comparison, the dynamic neural network‐based manipulability optimization control achieved optimized manipulability but with a loss of the accuracy of trajectory tracking (the global error was 1 mm compare to the 0.5 mm error of non‐optimized method).ConclusionsThe method validated in this work achieved optimized manipulability with a loss of error. Future works should be introduced to improve the accuracy of the surgical operation.
Fe1/TiO2 Hollow Microspheres: Fe and Ti Dual Active Sites Boosting the Photocatalytic Oxidation of NO
Authors: Hu Zhao , Li Xiaofang , Zhang Sushu , Li Qin , Fan Jiajie , Qu Xianlin , Lv Kangle 
Published: October 2020

AbstractRecently, single‐atom catalysts have aroused extensive attention in fields of clean energy and environmental protection due to their unique activity and efficient utilization of the active atoms. It is of great importance but still remains a great challenge to unveil the effect of single atoms on precise catalysis. Herein, it is reported that doping TiO2 hollow microspheres (TiO2‐HMSs) with single atomic Fe can boost the photoreactivity of TiO2‐HMSs towards NO oxidation due to the synergistic effects of atomically dispersed Fe and bonded Ti atom which act as dual active sites. The atomically dispersed Fe atoms occupy the subsurface Ti vacancies, and the interaction between Ti 3d and Fe 3d orbitals result in the formation of FeTi bond. Single atomic Fe modulates the electronic structure of the bonded Ti atoms by electron transfer, which facilitates the adsorption and activation of NO and O2 at Fe and bonded Ti sites, respectively. In addition, the introduction of single atomic Fe sharply suppresses the production of toxic NO2 byproduct. The synergistic effects of the dual active sites then cause a drastic promotion in photocatalytic oxidation of NO.
Software reuse analytics using integrated random forest and gradient boosting machine learning algorithm
Authors: Sandhu Amandeep Kaur , Batth Ranbir Singh 
Published: October 2020

AbstractThe term Cleaner Production (CP) for Production Companies is contemplated as influential to get sustainable production. CP mainly deals with three R's that is, reuse, reduce, and recycle. For software enterprise, the software reuse plays a pivotal role. Software reuse is a process of producing new products or software from the existing software by updating it. To extract useful information from the existing software data mining comes into light. The algorithms used for software reuse face issues related to maintenance cost, accuracy, and performance. Also, the currently used algorithm does not give accurate results on whether the component of software can be reused. Machine Learning gives the best results to predicate if the given software component is reusable or not. This paper introduces an integrated Random Forest and Gradient Boosting Machine Learning Algorithm (RFGBM) which test the reusability of the given software code considering the object‐oriented parameters such as cohesion, coupling, cyclomatic complexity, bugs, number of children, and depth inheritance tree. Further, the proposed algorithm is compared with J48, AdaBoostM1, LogitBoost, Part, One R, LMT, JRip, DecisionStump algorithms. Performance metrices like accuracy, error rate, Relative Absolute Error, and Mean Absolute Error are improved using RFGBM. This algorithm also utilizes data preprocessing with the help of an unsupervised filter to remove the missing value for efficiency improvement. Proposed algorithm outperforms existing in term of performance parameters.
Dressing bulk fields in AdS3
Authors: Kabat Daniel , Lifschytz Gilad 
Published: October 2020

Abstract
We study a set of CFT operators suitable for reconstructing a charged bulk scalar field ϕ in AdS3 (dual to an operator $$ \mathcal{O} $$
O
of dimension ∆ in the CFT) in the presence of a conserved spin-n current in the CFT. One has to sum a tower of smeared non-primary scalars $$ {\partial}_{+}^m{J}^{(m)} $$

∂
+
m

J

m

, where J(m) are primaries with twist ∆ and spin m built from $$ \mathcal{O} $$
O
and the current. The coefficients of these operators can be fixed by demanding that bulk correlators are well-defined: with a simple ansatz this requirement allows us to calculate bulk correlators directly from the CFT. They are built from specific polynomials of the kinematic invariants up to a freedom to make field redefinitions. To order 1/N this procedure captures the dressing of the bulk scalar field by a radial generalized Wilson line.
Risikostratifizierung von Notfällen während der COVID-19-Pandemie in der Zentralen Notaufnahme
Authors: Wieckenberg M. , Meier V. , Pfeiffer S. , Blaschke S. 
Published: October 2020

ZusammenfassungHintergrundDie COVID-19-Pandemie stellt für das Personal der Zentralen Notaufnahme (ZNA) eine sehr komplexe Herausforderung dar. Neben der regulären Notfallversorgung ist die frühzeitige Detektion und Isolation von COVID-19-Fällen erforderlich, um eine hausinterne Transmission der Infektion zu verhindern und den Schutz des Personals zu gewährleisten.MethodenEs wurde ein Modell zur Risikostratifizierung von SARS-CoV-2-Verdachts- und COVID-19-Fällen mit 5 Risikokategorien (RK) auf Basis der Kriterien des Robert-Koch Instituts (RKI) entwickelt und in der ZNA implementiert. Durch Verknüpfung der COVID-19-Risikokategorien mit spezifischen Isolations‑, Hygiene- und Personalschutzmaßnahmen wurden alle Bereiche der ZNA neu strukturiert. Retrospektiv erfolgte die statistische Auswertung aller stationären Fälle (n = 491) innerhalb eines vierwöchigen Zeitraums.ErgebnisseIm Patientenkollektiv wurdenn = 25 (5,1 %) SARS-CoV-2-positive Fälle identifiziert. Diese verteilten sich prozentual auf die Risikokategorien wie folgt: RK I – bestätigte SARS-CoV-2-Infektion 36 % (n = 9), RK II – begründete Verdachtsfälle 32 % (n = 8), RK III – differenzialdiagnostische Abklärung 12 % (n = 3), RK IV – geringe Wahrscheinlichkeit 8 % (n = 2) und RK V – kein Verdacht 12 % (n = 3). Bis dato ist keine Transmission der SARS-CoV-2-Infektion bei Mitarbeitern oder Patienten in der ZNA aufgetreten.SchlussfolgerungDie Einführung der COVID-19-Risikokategorien ermöglicht die zentrale Steuerung der krankenhaushygienisch relevanten Prozesse einer ZNA im Kontext der COVID-19-Pandemie. Durch eine stetige Reevaluation der Falldefinitionen können lokale Ausbruchssituationen berücksichtigt werden. Die COVID-19-Risikostratifizierung ermöglicht eine strikte Trennung von COVID-19/Non-COVID-19-Notfällen und stellt so die nosokomiale Infektionsprävention für Personal und Patienten sicher.
Identifying types in contest experiments
Authors: Fallucchi Francesco , Mercatanti Andrea , Niederreiter Jan 
Published: October 2020

AbstractWe apply the classifier-Lasso (Su et al. 2016) to detect the presence of latent types in two data sets of previous contest experiments, one that keeps the grouping of contestants fixed over the experiment and one that randomly regroups contestants after each round. Our results suggest that there exist three distinct types of players in both contest regimes. The majority of contestants in fixed groups behaves reciprocal to opponents’ previous choices. A higher share of reciprocators per group is associated to lower average overspending which hints at cooperative attempts. For experiments in which contestants are regrouped, we find a significantly lower share of ‘reciprocators’ and no significant association between the share of reciprocators and average efforts.
Use of tramadol and other analgesics following media attention and risk minimization actions from regulators: a Danish nationwide drug utilization study
Authors: Sørensen Anne Mette Skov , Rasmussen Lotte , Ernst Martin Thomsen , Mogensen Stine Hasling , Laursen Mona Vestergaard , Jimenez-Solem Espen , Pottegård Anton 
Published: October 2020

Abstract
Purpose
To describe the use of tramadol and other analgesics in Denmark focusing on the impact of media attention (June and December 2017) and regulatory actions (September 2017 and January 2018) on the use of tramadol.

Methods
Using nationwide registries, we identified all adults who filled a prescription for tramadol and other analgesics from 2014 to 2019. We described incidence rates, prevalence proportions, and total use of tramadol and other analgesics over time. We also described switching between analgesics, treatment duration, skewness in drug use, and doctor-shopping.

Results
From early 2017 until the end of 2019, total tramadol use decreased markedly while the use of morphine and oxycodone decreased slightly. The quarterly prevalence of tramadol use decreased from 32/1000 individuals in 2014 to 18/1000 at the end of 2019, dropping mainly at the time of media attention. Concomitantly, the quarterly prevalence increased for oxycodone (from 5.1 to 8.2) and morphine (from 8.5 to 9.8), mainly due to more short-term and sporadic users, and decreased for codeine (14 to 9.6). From 2014 to mid-2017, the incidence of tramadol use was stable (around 2.2/1000 person-months) but dropped in June 2017 to 1.7/1000, coinciding with the media attention. The incidence of tramadol use continued to decrease (to 1.1/1000 at the end of 2019).

Conclusion
We identified a decline in tramadol use coinciding with the media attention in 2017 and continuing during regulatory actions. There was generally no evidence of unintended effects on the utilization of opioids related to the media attention and regulatory actions.
Increased sagittal diameter of the vertebral arch aids in diagnosis of lumbar spondylolysis
Authors: Chen Shi-Zheng , Tong An-Ni , Tang He-Hu , Lv Zhen , Liu Shu-Jia , Liu Jie-Sheng , Zhang Jun-Wei 
Published: October 2020

Abstract
Objective
To identify a diagnostic indicator of lumbar spondylolysis visible in plain X-ray films.

Methods
One hundred and seventy-two patients with low back pain who received X-ray and computerized tomography (CT) examinations were identified and studied. They were divided into three groups: the spondylosis without spondylolisthesis (SWS) group, comprising 67 patients with bilateral pars interarticularis defects at L5 and without spondylolisthesis, the isthmic spondylolisthesis (IS) group, comprising 74 patients with L5/S1 spondylolisthesis and bilateral L5 pars interarticularis defects, and the control group, comprising 31 patients with low back pain but without spondylolysis. The sagittal diameters of the vertebral arch (SDVAs) of L4 and L5 were measured in lateral X-ray image, and the differences in SDVA between L4 and L5 (DSL4-5) in each case were calculated and analyzed.

Results
There were no significant differences in demographic characteristics among the three groups. In the SWS and IS groups, the SDVA of L5 was significantly longer than the SDVA of L4 (p < 0.001), whereas no significant difference found in the control group (p > 0.05). DSL4-5, in which the SDVA of L4 was subtracted from the SDVA of L5, significantly differed among the three groups (p < 0.001), and the normal threshold was provisionally determined to be 1.55 mm.

Conclusions
In bilateral L5 spondylolysis, the SDVA of L5 is wider than the SDVA of L4, and this difference is greater in isthmic spondylolisthesis. This sign in lateral X-rays may provide a simple and convenient aid for the diagnosis of spondylolysis.
Haploidentical transplantation in patients with multiple myeloma making use of natural killer cell alloreactive donors
Authors: Van Elssen Catharina , van Gorkom Gwendolyn , Voorter Christine , von dem Borne Peter , Meijer Ellen , Wieten Lotte , Bos Gerard 
Published: October 2020

AbstractDisease relapse is an important problem after allogeneic stem cell transplantations in multiple myeloma (MM). To test the hypothesis that natural killer (NK) cell alloreactivity in the setting of a haploidentical stem cell transplantation (haploSCT) can reduce the risk of myeloma relapse, we performed a small prospective phase 2 study in which we transplanted poor-risk MM patients using a killer cell immunoglobulin-like receptor (KIR)-ligand mismatched haploidentical donor. Patients received bone marrow grafts after reduced-intensity conditioning, with post-transplantation cyclophosphamide (PTCY) graft-versus-host-disease (GVHD) prophylaxis. The primary endpoint was 1.5-year progression-free survival (PFS); stopping rules were installed in case interim results made a benefit of 50% PFS at 1.5 years unlikely. After inclusion of 12 patients, of which 9 were evaluable for the primary endpoint, all patients relapsed within a median time of 90 days. All except 1 patient showed engraftment, with a median time to neutrophil recovery of 18 (12–30) days. The study was prematurely terminated based on the predefined stopping rules after the inclusion of 12 patients. With this small study, we show that in chemo-resistant myeloma patients, NK cell KIR-mismatch is not superior to conventional alloSCT. This strategy, however, can serve as a platform for new treatment concepts.Clinical Trial Registry: NCT02519114
Unveiling asexual reproductive traits in black corals: polyp bail-out in Antipathella subpinnata
Authors: Coppari Martina , Fumarola Lara , Bramanti Lorenzo , Romans Pascal , Pillot Rémi , Bavestrello Giorgio , Bo Marzia 
Published: October 2020

AbstractCnidarians are known to undergo reverse development as a survival mechanism against adverse environmental conditions. Polyp bail-out consists in the polyps’ detachment from the mother colony due to stressful conditions, followed by a complete tissue and cells rearrangement and in some cases in a regression into a simple, ciliated form. Here we describe a massive polyp bail-out event occurred in the mesophotic black coral Antipathella subpinnata in reared conditions. This is the first report of a bail-out event in this species providing new insights into the life cycle and ecology of black corals.