bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humeral Head Replacement in the Treatment of Comminuted Proximal Humeral Fracture
Authors: Zhang Xinghuo , Zhang Yakui , Guo Tao , Liu Liang , Cheng Wenhao 
Published: January 2021

ObjectiveTo investigate the outcomes of humeral head replacement in the treatment of patients with comminuted proximal humeral fracture.MethodsBetween February 2013 and September 2016, 56 patients underwent humeral head replacement in our hospital. Of them, 18 cases were diagnosed as comminuted proximal humeral fracture before the operation. The mean age of the patients was 69.5 years old (ranging from 61 to 79 years old). Of them, there were six males and 12 females. All the patients in this group had fresh fractures. They were all treated by artificial humeral head replacements. After the prosthesis was fixed by bone cement reliably, the greater or lesser trochanter and prosthesis handle were sutured and fixed firmly. The interval time from injury to operation ranged from 1 to 5 days. The Constant Functional Score, operation time, blood loss, nerve injury, joint dislocation rate, and infection rate were recorded at the final follow‐up. The clinical data of these patients were retrospectively studied. All of the data were recorded in average form.ResultsIn this study, the mean duration of follow‐up was 4 years, ranging from 3 to 6 years. The operation time ranged from 75 to 120 min, with the average of 82 min. The blood loss ranged from 100 to 400 mL, with the average of 210 mL. The mean score of Constant Functional Score was 83.5 ± 3.1. Of them, 14 cases achieved excellent and good (scores of more than 80), and four cases achieved moderate and poor (scores of less than 80). No patient suffered from joint dislocation, unstable joint, or infection after the operation. There were two patients with axillary nerve injury before the operation. However, the function could be recovered within 3–6 weeks after the surgery.ConclusionThe artificial humeral head replacement could be applied for the treatment of patients with comminuted proximal humeral fracture. During the surgery process, the stable structure of shoulder joint could be completely restructured, and the rehabilitation plan should be adjusted reasonably and timely after the operation.
Risk factors for progression from low level BK dnaemia to unfavorable outcomes after BK management via immunosuppressive reduction
Authors: Kharel Abish , Djamali Arjang , Jorgenson Margaret R. , Alzoubi Beyann , Swanson Kurtis J. , Garg Neetika , Aziz Fahad , Mohamed Maha A. , Mandelbrot Didier A. , Parajuli Sandesh 
Published: January 2021

AbstractBackgroundsEffective management of BK viremia (BKPyV‐DNAemia) in kidney transplant recipients (KTRs) involves regular monitoring and adjustment of immunosuppression. With this strategy, the majority of patients will clear BK or have ongoing, but non‐significant, low‐level BKPyV‐DNAemia. However, despite adjustments, some will develop more severe sequelae of BK including BKPyV‐DNAemia >5 log10copies/mL and BK nephropathy, and others may develop de novo DSA (dnDSA) or acute rejection (AR).MethodsThis was a single‐center study of KTRs transplanted at the University of Wisconsin‐Madison between 01/01/2015 and 12/31/2017. In this study, we sought to elucidate characteristics associated with the progression of BKPyV‐DNAemia to unfavorable outcomes after decreasing immunosuppressive medications for the management of BK viremia as described in consensus guidelines.ResultsA total of 224 KTRs fulfilled our selection criteria; 118 (53%) resolved or had persistent low DNAemia, 64 (28%) had severe BK/nephropathy, and 42 (19%) developed dnDSA or AR. In multivariable analysis, female gender (HR: 2.05; 95% CI: 1.08‐3.90;P = .02); previous rejection (HR: 2.90; 95% CI: 1.04‐8.12;P = .04), and early infection (HR: 0.81; 95% CI: 0.72‐0.90;P < .001) were associated with the development of severe BK/nephropathy. Conversely, non‐depleting induction at transplant (HR: 2.06; 95% CI: 1.03‐4.11;P = .03), HLA mismatches >3 (HR: 2.27; HR: 1.01‐5.06;P = .04), and delayed graft function (HR: 4.14; 95% CI: 1.12‐15.28;P = .03) were associated with development of dnDSA and/or rejection.ConclusionOur study suggests that almost half of KTRs with BKPyV‐DNAemia managed by our immunosuppressant adjustment protocol progress unfavorably. Identification of these risk factors could assist the frontline clinician in creating an individualized immunosuppressive modification plan potentially mitigating negative outcomes.
Aerobic Capacity According to Playing Role and Position in Elite Female Basketball Players Using Laboratory and Field Tests
Authors: Scanlan Aaron T. , Stojanović Emilija , Milanović Zoran , Teramoto Masaru , Jeličić Mario , Dalbo Vincent J. 
Published: January 2021

Purpose: To compare the aerobic capacity of elite female basketball players between playing roles and positions determined using maximal laboratory and field tests. Methods: Elite female basketball players from the National Croatian League were grouped according to playing role (starter: n = 8; bench: n = 12) and position (backcourt: n = 11; frontcourt: n = 9). All 20 players completed 2 maximal exercise tests in a crossover fashion 7 days apart. First, the players underwent a laboratory-based continuous running treadmill test with metabolic measurement to determine their peak oxygen uptake (VO2peak). The players then completed a maximal field-based 30-15 Intermittent Fitness Test (30-15 IFT) to estimate VO2peak. The VO2peak was compared using multiple linear regression analysis with bootstrap standard errors and playing role and position as predictors. Results: During both tests, starters attained a significantly higher VO2peak than bench players (continuous running treadmill: 47.4 [5.2] vs 44.7 [3.5] mL·kg−1·min−1, P = .05, moderate; 30-15 IFT: 44.9 [2.1] vs 41.9 [1.7] mL·kg−1·min−1, P < .001, large), and backcourt players attained a significantly higher VO2peak than frontcourt players (continuous running treadmill: 48.1 [3.8] vs 43.0 [3.3] mL·kg−1·min−1, P < .001, large; 30-15 IFT: 44.2 [2.2] vs 41.8 [2.0] mL·kg−1·min−1, P < .001, moderate). Conclusions: Starters (vs bench players) and guards (vs forwards and centers) possess a higher VO2peak irrespective of using laboratory or field tests. These data highlight the role- and position-specific importance of aerobic fitness to inform testing, training, and recovery practices in elite female basketball.
Contact interaction analysis of pion GTMDs
Authors: Zhang Jin-Li , Cui Zhu-Fang , Ping Jia-Lun , Roberts Craig D. 
Published: January 2021

AbstractA contact interaction is used to calculate an array of pion twist-two, -three and -four generalised transverse light-front momentum dependent parton distribution functions (GTMDs). Despite the interaction’s simplicity, many of the results are physically relevant, amongst them a statement that GTMD size and shape are largely prescribed by the scale of emergent hadronic mass. Moreover, proceeding from GTMDs to generalised parton distributions, it is found that the pion’s mass distribution form factor is harder than its electromagnetic form factor, which is harder than the gravitational pressure distribution form factor; the pressure in the neighbourhood of the pion’s core is commensurate with that at the centre of a neutron star; the shear pressure is maximal when confinement forces become dominant within the pion; and the spatial distribution of transversely polarised quarks within the pion is asymmetric. Regarding transverse momentum dependent distribution functions, their magnitude and domain of material support decrease with increasing twist. The simplest Wigner distribution associated with the pion’s twist-two dressed-quark GTMD is sharply peaked on the kinematic domain associated with valence-quark dominance; has a domain of negative support; and broadens as the transverse position variable increases in magnitude.
ATR Inhibition as an Attractive Therapeutic Resource against Cancer
Authors: Italiano Antoine 
Published: January 2021

AbstractSummary:In this issue of Cancer Discovery, Yap and colleagues demonstrate in a phase I trial enrolling 22 patients diagnosed with advanced solid tumors that BAY 1895344, a new potent and specific ATR inhibitor, is safe and able to induce durable responses in ATM-deficient tumors. This compelling clinical activity paves the way for innovative combination regimens that rely on exploitation of DNA damage response defects in cancer.See related article by Yap et al., p. 80.
Data mining approach to analyzing intrusion detection of wireless sensor network
Authors: Alauddin Rezvi Md , Moontaha Sidratul , Akter Trisha Khadija , Tasnim Cynthia Shamse , Ripon Shamim 
Published: January 2021

<span>Wireless sensor network (WSN) is a collection of wireless sensor nodes which are distributed in nature and a base station where the dispersed nodes are used to monitor and the physical conditions of the environment is recorded and then these data are organized into the base. Its application has been reached out from critical military application such as battlefield surveillance to traffic, health, industrial areas, intruder detection, security and surveillance. Due to various features in WSN it is very prone to various types external attacks. Preventing such attacks, intrusion detection system (IDS) is very important so that attacker cannot steal or manipulate data. Data mining is a technique that can help to discover patterns in large dataset. This paper proposed a data mining technique for different types of classification algorithms to detect denial of service (DoS) attacks which is of four types. They are Grayhole, Blackhole, Flooding and TDMA. A number of data mining techniques, such as KNN, Naïve Bayes, Logistic Regression, support vector machine (SVM) and ANN algorithms are applied on the dataset and analyze their performance in detecting the attacks. The analysis reveals the applicability of these algorithms for detecting and predicting such attacks and can be recommended for network specialist and analysts. </span>
V2X Communication System With Non-Orthogonal Multiple Access: Outage Performance Perspective
Authors: Nguyen Tu-Trinh , Do Dinh-Thuan 
Published: January 2021

<span class="fontstyle0">To achieve low-latency and high-reliability (LLHR) for applications in the vehicle-toeverything (V2X) networks, the non-orthogonal multiple access (NOMA) based Long Term Evolution (LTE)-based is introduced a promising technology. NOMA-V2X provides higher spectrum efficiency compared with the orthogonal multiple access (OMA) based V2X. This study propose two-way relay assisted NOMA-V2X transmission by exploiting amplify-and-forward (AF) and full-duplex. We derive expressions of outage probability to evaluate performance of two vehicles and to improve the quality of service (QoS) for the device with the poor channel conditions. These expressions are further verified by Monte-Carlo simulations.</span> <br /><br />
"النار العاتية التي ذاقت من طعم وهج اللهيب:"
Authors: هاني رشوان 
Published: January 2021

This article offers the first Arabic translation of a praise hymn dedicated to Ramsess II (d. 1213 B.C.E.), with philological and poetic commentaries. The text was carved on the facade of Abū Simbel temple twice because of its exceptional literary nature, as this study demonstrates. I discuss why Euro- American scholars were unable to separate the literary dimensions of the praise hymns from its political framework, and also tackle the pictorial nature of ancient Egyptian writing, providing the Arabic reader with the necessary instruments for understanding the several visual features that were creatively deployed by the writer to enhance the reading process of this particular praise hymn. I then trace the early foundations of premodern Arabic khiṭāba and its close relation to constructing oral/aural arguments in comparison with balāgha that deals with the literary devices of the Qur’ānic text.
This study breaks new ground in the discipline of comparative literature by establishing a collation between the two praise hymns of Ramsess II (d. 1213 B.C.E.) and Senwosret III (d. 1839 B.C.E.). This collation makes it possible to rediscover the way each eulogist built unique or similar images to describe the praised king. The article discusses several problematic questions of loanwords to pave the way for further research on ancient Egyptian words that were incorporated inside the classical Arabic dictionary, and the analysis ends with an ancient Egyptian-Arabic lexicon of the hymn under study. It is hoped that this may encourage the new generation of Egyptian Egyptologists to generate a comprehensive dictionary of the ancient Egyptian language based on direct engagement with ancient Egyptian literary texts.
RETRACTED ARTICLE: Inhibited MicroRNA-301 Restrains Angiogenesis and Cell Growth in Esophageal Squamous Cell Carcinoma by Elevating PTEN
Authors: Wang Bin , Hua Peiyan , Wang Ruimin , Li Jindong , Zhang Guangxin , Jin Chengyan , Zhang Yan 
Published: January 2021

Abstract
Objective
Esophageal squamous cell carcinoma (ESCC) is featured by early metastasis and late diagnosis. MicroRNA-301 (miR-301) is known to participate in diverse cancers. Nevertheless, effects of miR-301 on ESCC remain unexplored. Thus, we aim to explore the role of miR-301 in ESCC progression.

Methods
Expression of miR-301 and phosphatase and tensin homologue (PTEN) in ESCC tissues and cell lines was assessed. Next, the screened cells were treated with altered miR-301 or PTEN oligonucleotide and plasmid, and then, the colony formation ability, cell viability, migration, invasion, cell cycle distribution and apoptosis of ESCC cells were assessed. Moreover, tumor growth and microvessel density (MVD) were also assessed, and the targeting relationship between miR-301 and PTEN was affirmed.

Results
MiR-301 was upregulated, and PTEN was downregulated in ESCC tissues and cells. KYSE30 cells and Eca109 cells were selected for functional assays. In KYSE30 cells, inhibited miR-301 or overexpressed PTEN suppressed cell malignant behaviors, and silenced PTEN eliminated the impact of miR-301 inhibition on ESCC progression. In Eca109 cells, miR-301 overexpression or PTEN inhibition promoted cell malignant behaviors, and PTEN overexpression reversed the effects of miR-301 elevation on ESCC progression. The in vivo assay revealed that miR-301 inhibition or PTEN overexpression repressed ESCC tumor growth and MVD, and miR-301 elevation or PTEN reduction had contrary effects. Moreover, PTEN was targeted by miR-301.

Conclusion
Taken together, results in our study revealed that miR-301 affected cell growth, metastasis and angiogenesis via regulating PTEN expression in ESCC.
The role of β2 integrin in dendritic cell migration during infection
Authors: Altorki Tarfa , Muller Werner , Brass Andrew , Cruickshank Sheena 
Published: January 2021

Abstract
Background
Dendritic cells (DCs) play a key role in shaping T cell responses. To do this, DCs must be able to migrate to the site of the infection and the lymph nodes to prime T cells and initiate the appropriate immune response. Integrins such as β2 integrin play a key role in leukocyte adhesion, migration, and cell activation. However, the role of β2 integrin in DC migration and function in the context of infection-induced inflammation in the gut is not well understood. This study looked at the role of β2 integrin in DC migration and function during infection with the nematode worm Trichuris muris. Itgb2tm1Bay mice lacking functional β2 integrin and WT littermate controls were infected with T. muris and the response to infection and kinetics of the DC response was assessed.

Results
In infection, the lack of functional β2 integrin significantly reduced DC migration to the site of infection but not the lymph nodes. The lack of functional β2 integrin did not negatively impact T cell activation in response to T. muris infection.

Conclusions
This data suggests that β2 integrins are important in DC recruitment to the infection site potentially impacting the initiation of innate immunity but is dispensible for DC migration to lymph nodes and T cell priming in the context of T. muris infection.
Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis
Authors: Luo Mei , Zhuang Xiaojun , Tian Zhenyi , Xiong Lishou 
Published: January 2021

AbstractBackgroundShort-chain fatty acids (SCFAs) and serotonin (5-hydroxytryptamine, 5-HT) may be associated with the pathogenesis of irritable bowel syndrome (IBS). There are some reports of alterations in SCFAs and 5-HT in IBS, but their results are inconsistent. We aimed to perform a meta-analysis to assess alterations in SCFAs and 5-HT in IBS patients and their potential role in the abnormal brain-gut-microbiota (BGM) axis.MethodsCase–control studies detecting SCFAs and 5-HT in IBS patients were identified from PubMed, Web of Science, Cochrane Library, and Scopus databases to identify relevant articles up to September 2018. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) of SCFAs and 5-HT were calculated by REVIEW MANAGER 5.3 to evaluate the alterations of 5-HT and SCFAs in IBS.ResultsFive studies on SCFAs and 5 on 5-HT in IBS patients were included. As compared to healthy controls (HCs), the SMDs of 5-HT in IBS patients was 2.35 (95% CI 0.46–4.24) and the SMDs of total SCFAs, acetic acid, propionic acid, and butyric acid in IBS patients were − 0.01 (95% CI − 0.57–0.55), − 0.04 (95% CI − 0.55–0.47), 0.07 (95% CI − 0.45–0.60), and − 0.00 (95% CI − 0.49–0.49), respectively.ConclusionsThere was an increase in 5-HT in blood of IBS patients, indicating the increased 5-HT in blood may be involved in IBS pathogenesis. However, there were no significant differences in SCFAs in feces between IBS patients and HCs. But the study did not differentiate between subgroups of IBS. These findings might provide insight for future studies of the BGM axis in the pathogenesis of IBS.Mei Luo and Xiaojun Zhuang contributed equally to the writing of this article
Imaging features of hemangioma in long tubular bones
Authors: Cao Lei , Wen Jin-Xu , Han Shu-Man , Wu Hui-Zhao , Peng Zhi-Gang , Yu Bao-Hai , Zhong Zhi-Wei , Sun Tao , Wu Wen-Juan , Gao Bu-Lang 
Published: January 2021

Abstract
Background
To investigate the imaging features of hemangiomas in long tabular bones for better diagnosis.

Methods
Twenty-four patients with long bone hemangiomas confirmed by pathology were enrolled. Nineteen patients had plain radiography, fourteen patients had computed tomography (CT) and eleven had magnetic resonance imaging (MRI). The hemangioma was divided into medullary [13], periosteal [6] and intracortical type [5].

Results
Among 19 patients with plain radiography, eleven patients were medullary, three periosteal, and five intracortical. In the medullary type, the lesion was primarily osteolytic, including five cases with irregular and unclear rims and one lesion having osteosclerotic and unclear rims. In three patients with the periosteal type, the lesion had clear rims with involvement of the cortical bone in the form of bone defect, including two cases with local thickened bone periosteum and one case having expansile periosteum. Five intracortical hemangiomas had intracortical osteolytic lesions with clear margins. Among 14 patients with CT imaging, 8 cases were medullary, three periosteal, and three intracortical. Among 8 medullary hemangiomas, one had ground glass opacity, and seven had osteolytic, expansile lesions like soft tissue density with no calcification. In three periosteal cases, the lesion was osteolytic with thickened periosteum and narrowed medullary cavity. In three intracortical hemangiomas, the lesion was of even soft tissue density with no calcification. Among 11 patients with MRI imaging, seven were medullary, two periosteal, and two intracortical. Among 7 medullary lesions, six were of hypointense signal on T1WI and hyperintensesignal on T2 WI. In two periosteal cases, the periosteum was thickened, with one case being of equal signal, and the other having no signal. Two intracortical hemangiomas were both of slightly low signal on T1WI but hyperintense signal on T2WI.

Conclusions
The long bone hemangiomas had characteristic cystic honeycomb-like presentations in plain radiograph. CT and MRI imagings are helpful for diagnosis of hemangiomas in long bone.
Comparing Charlson and Elixhauser comorbidity indices with different weightings to predict in-hospital mortality: an analysis of national inpatient data
Authors: Sharma Narayan , Schwendimann René , Endrich Olga , Ausserhofer Dietmar , Simon Michael 
Published: January 2021

AbstractBackgroundUnderstanding how comorbidity measures contribute to patient mortality is essential both to describe patient health status and to adjust for risks and potential confounding. The Charlson and Elixhauser comorbidity indices are well-established for risk adjustment and mortality prediction. Still, a different set of comorbidity weights might improve the prediction of in-hospital mortality. The present study, therefore, aimed to derive a set of new Swiss Elixhauser comorbidity weightings, to validate and compare them against those of the Charlson and Elixhauser-based van Walraven weights in an adult in-patient population-based cohort of general hospitals.MethodsRetrospective analysis was conducted with routine data of 102 Swiss general hospitals (2012–2017) for 6.09 million inpatient cases. To derive the Swiss weightings for the Elixhauser comorbidity index, we randomly halved the inpatient data and validated the results of part 1 alongside the established weighting systems in part 2, to predict in-hospital mortality. Charlson and van Walraven weights were applied to Charlson and Elixhauser comorbidity indices. Derivation and validation of weightings were conducted with generalized additive models adjusted for age, gender and hospital types.ResultsOverall, the Elixhauser indices, c-statistic with Swiss weights (0.867, 95% CI, 0.865–0.868) and van Walraven’s weights (0.863, 95% CI, 0.862–0.864) had substantial advantage over Charlson’s weights (0.850, 95% CI, 0.849–0.851) and in the derivation and validation groups. The net reclassification improvement of new Swiss weights improved the predictive performance by 1.6% on the Elixhauser-van Walraven and 4.9% on the Charlson weights.ConclusionsAll weightings confirmed previous results with the national dataset. The new Swiss weightings model improved slightly the prediction of in-hospital mortality in Swiss hospitals. The newly derive weights support patient population-based analysis of in-hospital mortality and seek country or specific cohort-based weightings.
DLG1-AS1 is activated by MYC and drives the proliferation and migration of hepatocellular carcinoma cells through miR-497-5p/SSRP1 axis
Authors: Min Jie , Jin Dayong , Zhang Feng , Kang Yanxia , Qi Yuhong , Du Pang 
Published: January 2021

Abstract
Background
Long non-coding RNAs (lncRNAs) have been reported to be biological regulators in hepatocellular carcinoma (HCC). DLG1 antisense RNA 1 (DLG1-AS1) has been found to be up-regulated in cervical cancer. However, its function and underlying mechanism in HCC remains unknown.

Methods
DLG1-AS1 expression was assessed in HCC cells and normal cell by RT-qPCR. Luciferase reporter assay, RNA pull down assay and RIP assay were used to demonstrate the interaction between DLG1-AS1 and miR-497-5p.

Results
DLG1-AS1 was highly expressed in HCC cells. Silencing of DLG1-AS1 led to the inhibition of HCC cell growth and migration. Besides, MYC induced the transcriptional activation of DLG1-AS1. MYC could facilitate HCC cellular processes by up-regulating DLG1-AS1. MiR-497-5p could interact with DLG1-AS1 in HCC cells. Down-regulation of miR-497-5p could reverse the impacts of DLG1-AS1 silencing on HCC cells. SSRP1 expression could be positively regulated by DLG1-AS1 but was negatively regulated by miR-497-5p. Knockdown of DLG1-AS1 suppressed tumor growth in nude mice.

Conclusions
DLG1-AS1 is activated by MYC and functions as an oncogene in HCC via miR-497-5p/SSRP1 axis.