bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low noise all-fiber amplification of a coherent supercontinuum at 2 µm and its limits imposed by polarization noise
Authors: Heidt Alexander M. , Modupeh Hodasi Joanna , Rampur Anupamaa , Spangenberg Dirk-Mathys , Ryser Manuel , Klimczak Mariusz , Feurer Thomas 
Published: October 2020

AbstractWe report a low noise, broadband, ultrafast Thulium/Holmium co-doped all-fiber chirped pulse amplifier, seeded by an Erbium-fiber system spectrally broadened via coherent supercontinuum generation in an all-normal dispersion photonic crystal fiber. The amplifier supports a − 20 dB bandwidth of more than 300 nm and delivers high quality 66 fs pulses with more than 70 kW peak power directly from the output fiber. The total relative intensity noise (RIN) integrated from 10 Hz to 20 MHz is 0.07%, which to our knowledge is the lowest reported RIN for wideband ultrafast amplifiers operating at 2 µm to date. This is achieved by eliminating noise-sensitive anomalous dispersion nonlinear dynamics from the spectral broadening stage. In addition, we identify the origin of the remaining excess RIN as polarization modulational instability (PMI), and propose a route towards complete elimination of this excess noise. Hence, our work paves the way for a next generation of ultra-low noise frequency combs and ultrashort pulse sources in the 2 µm spectral region that rival or even outperform the excellent noise characteristics of Erbium-fiber technology.
Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome
Authors: Aalders Jeffrey , Léger Laurens , Van der Meeren Louis , Van den Vreken Natasja , Skirtach Andre G. , Sinha Sanjay , De Backer Julie , van Hengel Jolanda 
Published: October 2020

AbstractMarfan syndrome (MFS) is a systemic disorder of connective tissue caused by pathogenic variants in the fibrillin-1 (FBN1) gene. Myocardial dysfunction has been demonstrated in MFS patients and mouse models, but little is known about the intrinsic effect on the cardiomyocytes (CMs). In this study, both induced pluripotent stem cells derived from a MFS-patient and the line with the corrected FBN1 mutation were differentiated to CMs. Several functional analyses are performed on this model to study MFS related cardiomyopathy. Atomic force microscopy revealed that MFS CMs are stiffer compared to corrected CMs. The contraction amplitude of MFS CMs is decreased compared to corrected CMs. Under normal culture conditions, MFS CMs show a lower beat-to-beat variability compared to corrected CMs using multi electrode array. Isoproterenol-induced stress or cyclic strain demonstrates lack of support from the matrix in MFS CMs. This study reports the first cardiac cell culture model for MFS, revealing abnormalities in the behavior of MFS CMs that are related to matrix defects. Based on these results, we postulate that impaired support from the extracellular environment plays a key role in the improper functioning of CMs in MFS.
Dietary inflammatory index and metabolic syndrome in Iranian population (Fasa Persian Cohort Study)
Authors: Ariya Mohammad , Shahraki Hadi Raeisi , Farjam Mojtaba , Ehrampoush Elham , Bahramali Ehsan , Homayounfar Reza , Shivappa Nitin , Hebert James R. 
Published: October 2020

AbstractMetabolic syndrome (MetS) is one of the risk factors for all causes of mortality. Inflammation is an important risk factor for MetS. The present cross-sectional study aimed to investigate the relationship between MetS and pro-inflammatory diet by using the food inflammation index (DII). This study consists of 10,017 participants with an age range of 35 to 70 years. The Fasa Cohort Study (FACS) population (Fars Province, Iran) was used to collect data. The DII was estimated according to Shivappa et al. method using a validated 125-item FFQ. To determine the association between MetS components and DII Logistic regression was used (P > 0.05). The overall mean of DII was − 0.89 ± 1.74. However, adjusted multinomial logistic regression indicates each unit increase in waist circumference (WC) (OR 0.98, 95% CI 0.96–0.99) and HDL-C (OR 0.99, 95% CI 0.98–0.99) was associated with significantly decreased odds of being in the 4th DII quartile in men and all participations respectively, there is no statistically significant relationship between MetS and DII. Overall, although people in the highest quartile of inflammatory food consumption had more likely to develop MetS, this relationship was not statistically significant among males and females.
Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis
Authors: Kwan Thaddaeus , Kazamel Mohamed , Thoenes Kristina , Si Ying , Jiang Nan , King Peter H. 
Published: October 2020

AbstractSkeletal muscle and the neuromuscular junction are the earliest sites to manifest pathological changes in amyotrophic lateral sclerosis (ALS). Based on prior studies, we have identified a molecular signature in muscle that develops early in ALS and parallels disease progression. This signature represents an intersection of signaling pathways including Smads, TGF-β, and vitamin D. Here, we show that the Wnt antagonist, Frizzled Related Protein (FRZB), was increased in ALS muscle samples and to a variable extent other denervating disease but only minimally in acquired myopathies. In the SOD1G93A mouse, FRZB was upregulated in the early stages of disease (between 40 and 60 days) until end-stage. By immunohistochemistry, FRZB was predominantly localized to endomysial connective tissue and to a lesser extent muscle membrane. There was a significant increase in immunoreactivity surrounding atrophied myofibers. Because FRZB is a Wnt antagonist, we assessed β-catenin, the canonical transducer of Wnt signaling, and found increased levels mainly at the muscle membrane. In summary, we show that FRZB is part of a molecular signature of muscle denervation that may reflect disease progression in ALS. Our findings open up avenues for future investigation as to what roles FRZB and Wnt signaling might be playing in muscle denervation/reinnervation.
Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients
Authors: Hannappe Marc-Antoine , Arnould Louis , Méloux Alexandre , Mouhat Basile , Bichat Florence , Zeller Marianne , Cottin Yves , Binquet Christine , Vergely Catherine , Creuzot-Garcher Catherine , Guenancia Charles 
Published: October 2020

AbstractWe aimed to compare retinal vascular density in Optical Coherence Tomography Angiography (OCT-A) between patients hospitalized for acute coronary syndrome (ACS) and control patients and to investigate correlation with angiogenesis biomarkers. Patients hospitalized for an acute coronary syndrome (ACS) in the Intensive Care Unit were included in the “high cardiovascular risk” group while patients without cardiovascular risk presenting in the Ophthalmology department were included as “control”. Both groups had blood sampling and OCT-A imaging. Retina microvascularization density in the superficial capillary plexus was measured on 3 × 3 mm angiograms centered on the macula. Angiopoietin-2, TGF-β1, osteoprotegerin, GDF-15 and ST-2 were explored with ELISA or multiplex method. Overall, 62 eyes of ACS patients and 42 eyes of controls were included. ACS patients had significantly lower inner vessel length density than control patients (p = 0.004). A ROC curve found that an inner vessel length density threshold below 20.05 mm−1 was moderately associated with ACS. Significant correlation was found between serum levels of angiopoietin-2 and osteoprotegerin, and retinal microvascularization in OCT-A (R = − 0.293, p = 0.003; R = − 0.310, p = 0.001). Lower inner vessel length density measured with OCT-A was associated with ACS event and was also correlated with higher concentrations of angiopoietin-2 and osteoprotegerin.
Deep neural networks detect suicide risk from textual facebook posts
Authors: Ophir Yaakov , Tikochinski Refael , Asterhan Christa S. C. , Sisso Itay , Reichart Roi 
Published: October 2020

AbstractDetection of suicide risk is a highly prioritized, yet complicated task. Five decades of research have produced predictions slightly better than chance (AUCs = 0.56–0.58). In this study, Artificial Neural Network (ANN) models were constructed to predict suicide risk from everyday language of social media users. The dataset included 83,292 postings authored by 1002 authenticated Facebook users, alongside valid psychosocial information about the users. Using Deep Contextualized Word Embeddings for text representation, two models were constructed: A Single Task Model (STM), to predict suicide risk from Facebook postings directly (Facebook texts → suicide) and a Multi-Task Model (MTM), which included hierarchical, multilayered sets of theory-driven risk factors (Facebook texts → personality traits → psychosocial risks → psychiatric disorders → suicide). Compared with the STM predictions (0.621 ≤ AUC ≤ 0.629), the MTM produced significantly improved prediction accuracy (0.697 ≤ AUC ≤ 0.746), with substantially larger effect sizes (0.729 ≤ d ≤ 0.936). Subsequent content analyses suggested that predictions did not rely on explicit suicide-related themes, but on a range of text features. The findings suggest that machine learning based analyses of everyday social media activity can improve suicide risk predictions and contribute to the development of practical detection tools.
Mode hybridization analysis in thin film lithium niobate strip multimode waveguides
Authors: Kaushalram Archana , Hegde Gopalkrishna , Talabattula Srinivas 
Published: October 2020

AbstractMode hybridization phenomenon in air-cladded X-cut Y-propagating and Z-propagating thin film lithium niobate strip multimode waveguides is numerically studied and a mathematical relation between structural parameters leading to hybrid modes is formulated. Dependence of hybrid modes on waveguide dimensions, sidewall angles and wavelength is also analyzed. The results obtained are used to design lithium niobate on insulator (LNOI) taper for converting fundamental TM mode to higher order TE mode, and an optimum length for achieving a high conversion efficiency of 99.5% is evaluated. Birefringent Y-propagating LN and isotropic Z-propagating LN tapers are compared in terms of length, figures of merit, and fabrication tolerance. Tapers exhibit a broad bandwidth of 200 nm with an extinction ratio less than − 18 dB. The results of mode hybridization analysis are useful in design optimization of adiabatic tapers, tunable time delays, optical interconnects, mode converters and demultiplexers for mode division multiplexing (MDM) applications.
Acute and sub-chronic effects of copper on survival, respiratory metabolism, and metal accumulation in Cambaroides dauricus
Authors: Bao Jie , Xing Yuenan , Feng Chengcheng , Kou Shiyu , Jiang Hongbo , Li Xiaodong 
Published: October 2020

AbstractTrace metal contamination in the aquatic ecosystem occurs worldwide: although copper is an essential trace metal, it is considered as a pollutant at certain levels in China. Freshwater crayfish Cambaroides dauricus is a commercially important wild species in northeastern China, in which is an important heavy industry area. The population of C. dauricus was decreasing sharply due to the environmental pollution and human intervention over the past 20 years. However, nothing is known regarding the responses of this species to trace metal toxicants. This study aimed to determine the acute and chronic toxicity of Cu and its toxicological effects on respiratory metabolism, as well as Cu accumulation in C. dauricus. The acute (96 h) median lethal concentration (LC50) value of 32.5 mg/L was detected in C. dauricus. Then, acute (96 h; 8.24, 16.48 mg/L) and sub-chronic (14 days; 2.06, 4.12 mg/L) exposure in Cu was investigated by estimating the oxygen consumption rate, ammonium excretion rate, and Cu accumulation. Both acute and sub-chronic Cu exposure induced an inhibition of the oxygen consumption rate and ammonium excretion rate, and thereby, an increased O:N ratio. The shift in O:N ratio indicated a metabolic substrate shift towards lipid and carbohydrate metabolism under Cu stress. Cu accumulation in the hepatopancreas and muscles throughout the study was found to be time-dependent and concentration-dependent. The maximum accumulation in the hepatopancreas and muscle were almost 31.6 folds of the control after 14 days’ exposure to 4.12 mg/L concentration. Based on the present work, we suggest that crayfish be considered a potential bioindicator of environmental pollution in freshwater systems. The study provides basic information for further understanding of the toxicological responses of this species to trace metals.
Roles of ethylene, jasmonic acid, and salicylic acid and their interactions in frankincense resin production in Boswellia sacra Flueck. trees
Authors: Yamamoto Fukuju , Iwanaga Fumiko , Al-Busaidi Ahmed , Yamanaka Norikazu 
Published: October 2020

AbstractThe roles of ethylene, jasmonic acid, and salicylic acid and their interactions in frankincense resin production in Boswellia sacra trees growing in the drylands of Oman were studied. On March 18 (Experiment 1) and September 17 (Experiment 2), 2018, 32-year-old B. sacra trees with multiple trunks were selected at the Agricultural Experiment Station, Sultan Qaboos University, Oman. Various lanolin pastes containing Ethrel, an ethylene-releasing compound; methyl jasmonate; sodium salicylate; and combinations of these compounds were applied to debarked wounds 15 mm in diameter on the trunks. After a certain period, the frankincense resin secreted from each wound was harvested and weighed. The anatomical characteristics of the resin ducts were also studied in the bark tissue near the upper end of each wound. The combination of Ethrel and methyl jasmonate greatly enhanced frankincense resin production within 7 days in both seasons. The application of methyl jasmonate alone, sodium salicylate alone or a combination of both did not affect resin production. These findings suggest a high possibility of artificial enhancement of frankincense resin production by the combined application of Ethrel and methyl jasmonate to B. sacra trees.
Multiplex coherent anti-Stokes Raman scattering microspectroscopy detection of lipid droplets in cancer cells expressing TrkB
Authors: Guerenne-Del Ben Tiffany , Couderc Vincent , Duponchel Ludovic , Sol Vincent , Leproux Philippe , Petit Jean-Michel 
Published: October 2020

AbstractFor many years, scientists have been looking for specific biomarkers associated with cancer cells for diagnosis purposes. These biomarkers mainly consist of proteins located at the cell surface (e.g. the TrkB receptor) whose activation is associated with specific metabolic modifications. Identification of these metabolic changes usually requires cell fixation and specific dye staining. MCARS microspectroscopy is a label-free, non-toxic, and minimally invasive method allowing to perform analyses of live cells and tissues. We used this method to follow the formation of lipid droplets in three colorectal cancer cell lines expressing TrkB. MCARS images of cells generated from signal integration of CH2 stretching modes allow to discriminate between lipid accumulation in the endoplasmic reticulum and the formation of cytoplasmic lipid droplets. We found that the number of the latter was related to the TrkB expression level. This result was confirmed thanks to the creation of a HEK cell line which over-expresses TrkB. We demonstrated that BDNF-induced TrkB activation leads to the formation of cytoplasmic lipid droplets, which can be abolished by K252a, an inhibitor of TrkB. So, MCARS microspectroscopy proved useful in characterizing cancer cells displaying an aberrant lipid metabolism.
Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis
Authors: Martín Maximilino , Millan Andrea , Ferraro Florencia , Tetzlaff Walter F. , Chiappe Ezequiel Lozano , Botta Eliana , Castro Marcelo , Boero Laura , Rey Jorge , Daruich Jorge , Frechtel Gustavo , Meroño Tomas , Cerrone Gloria , Brites Fernando 
Published: October 2020

AbstractBackground: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.Aim: To evaluate the relationship between ATL and IO in patients with HH.Methods: Cross-sectional study including 25 patients with HH: 8 with IO and 17 without IO (ferritin &lt; 300 ng/ml) and 25 healthy controls. Inclusion criteria were: age &gt; 18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.Results: HH patients with IO were older (P&lt;0.001) and showed higher ferritin concentration (P&lt;0.001). Patients with HH, disregarding the iron status, showed higher glucose and body mass index (BMI) than controls (both P&lt;0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6–14), without IO: 13 (9–20), and controls: 19 (15–25) kilobase pairs, P&lt;0.01]; with a linear trend within groups (P for trend &lt;0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose (P&lt;0.05).Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.
AQUA: a collection of H2O equations of state for planetary models
Authors: Haldemann Jonas , Alibert Yann , Mordasini Christoph , Benz Willy 
Published: October 2020

Context. Water is one of the key chemical elements in planetary structure modelling. Due to its complex phase diagram, equations of state often only cover parts of the pressure-temperature space needed in planetary modelling.
Aims. We aim to construct an equation of state of H2O spanning a very wide range, from 0.1 Pa to 400 TPa and 150 to 105 K, which can be used to model the interior of planets.
Methods. We combined equations of state valid in localised regions to form a continuous equation of state spanning over the above-mentioned pressure and temperature range.
Results. We provide tabulated values for the most important thermodynamic quantities: the density, adiabatic temperature gradient, entropy, internal energy, and bulk speed of sound of water over this pressure and temperature range. For better usability we also calculated density-temperature and density-internal energy grids. We discuss further the impact of this equation of state on the mass radius relation of planets compared to other popular equations of state like ANEOS and QEOS.
Conclusions. AQUA is a combination of existing equations of state useful for planetary models. We show that, in most regions, AQUA is a thermodynamic consistent description of water. At pressures above 10 GPa, AQUA predicts systematic larger densities than ANEOS or QEOS. This is a feature that was already present in a previously proposed equation of state, which is the main underlying equation of this work. We show that the choice of the equation of state can have a large impact on the mass-radius relation, which highlights the importance of future developments in the field of equations of state and regarding experimental data of water at high pressures.
The bright end of the infrared luminosity functions and the abundance of hyperluminous infrared galaxies
Authors: Wang L. , Gao F. , Best P. N. , Duncan K. , Hardcastle M. J. , Kondapally R. , Małek K. , McCheyne I. , Sabater J. , Shimwell T. , Tasse C. , Bonato M. , Bondi M. , Cochrane R. K. , Farrah D. , Gürkan G. , Haskell P. , Pearson W. J. , Prandoni I. , Röttgering H. J. A. , Smith D. J. B. , Vaccari M. , Williams W. L. 
Published: October 2020

Aims. We provide the most accurate estimate yet of the bright end of the infrared (IR) luminosity functions (LFs) and the abundance of hyperluminous IR galaxies (HLIRGs) with IR luminosities >1013L⊙, thanks to the combination of the high sensitivity, angular resolution, and large area of the LOFAR Deep Fields, which probes an unprecedented dynamic range of luminosity and volume.
Methods. We cross-match Herschel sources and LOFAR sources in Boötes (8.63 deg2), Lockman Hole (10.28 deg2), and ELAIS-N1 (6.74 deg2) with rms sensitivities of ~32, 22, and 20 μJy beam−1, respectively. We divide the matched samples into “unique” and “multiple” categories. For the multiple matches, we de-blend the Herschel fluxes using the LOFAR positions and the 150-MHz flux densities as priors. We perform spectral energy distribution fitting, combined with multi-wavelength counterpart identifications and photometric redshift estimates, to derive IR luminosities.
Results. The depth of the LOFAR data allows us to identify highly complete (~92% completeness) samples of bright Herschel sources with a simple selection based on the 250 μm flux density (45, 40, and 35 mJy in Boötes, Lockman Hole, and ELAIS-N1, respectively). Most of the bright Herschel sources fall into the unique category (i.e. a single LOFAR counterpart). For the multiple matches, there is excellent correspondence between the radio emission and the far-IR emission. We find a good agreement in the IR LFs with a previous study out to z ~ 6 which used de-blended Herschel data. Our sample gives the strongest and cleanest indication to date that the population of HLIRGs has surface densities of ~5 to ~18/deg2 (with variations due to a combination of the applied flux limit and cosmic variance) and an uncertainty of a factor of ≲2. In comparison, the GALFORM semi-analytic model significantly under-predicts the abundance of HLIRGs.