bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-stage heat-pipe heat exchanger for improving energy efficiency of the HVAC system in a hospital operating room
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Authors: Sukarno Ragil , Putra Nandy , Hakim Imansyah Ibnu , Rachman Fadhil Fuad , Mahlia Teuku Meurah Indra 
Published: June 2020

Abstract
The demands of specific requirements related to thermal comforts, such as temperature, relative humidity, inside air exchange and other factors required in a hospital operating rooms, have necessitated the development of energy-efficient heating, ventilation and air conditioning (HVAC) systems and efficient heat-recovery system using a heat-pipe heat exchanger (HPHE). The experiment was conducted by using HPHEs having three, six and nine rows, with four heat pipes in each row, arranged in a staggered configuration with a variation of fresh-air inlet temperature and velocity. The theoretical analysis was conducted using the ε-NTU method for predicting the effectiveness, outlet temperature of the evaporator side and energy recovery of the HPHE. The experimental results indicated that increasing the air-inlet temperature in the evaporator section and the number of rows increased the HPHE effectiveness but increasing the air-inlet velocity reduced the effectiveness. The highest effectiveness of 62.6% was obtained at an air-inlet temperature of 45°C with an air-inlet velocity of 2 m/s and a 9-row HPHE. The energy recovery of the HPHE increased with the number of rows, air-inlet temperature and air velocity in the evaporator section. The ε-NTU method can be used as a comparison method in the analysis of heat-recovery systems that apply HPHE air conditioning systems. Heat pipes that utilize cold-air exhaust from a room in an HVAC system can enhance efficiency and reduce emissions.
Dirac structures and variational formulation of port-Dirac systems in nonequilibrium thermodynamics
Authors: Gay-Balmaz François , Yoshimura Hiroaki 
Published: June 2020

Abstract
The notion of implicit port-Lagrangian systems for nonholonomic mechanics was proposed in Yoshimura & Marsden (2006a, J. Geom. Phys., 57, 133–156; 2006b, J. Geom. Phys., 57, 209–250; 2006c, Proc. of the 17th International Symposium on Mathematical Theory of Networks and Systems, Kyoto) as a Lagrangian analogue of implicit port-Hamiltonian systems. Such port-systems have an interconnection structure with ports through which power is exchanged with the exterior and which can be modeled by Dirac structures. In this paper, we present the notions of implicit port-Lagrangian systems and port-Dirac dynamical systems in nonequilibrium thermodynamics by generalizing the Dirac formulation to the case allowing irreversible processes, both for closed and open systems. Port-Dirac systems in nonequilibrium thermodynamics can be also deduced from a variational formulation of nonequilibrium thermodynamics for closed and open systems introduced in Gay-Balmaz & Yoshimura (2017a, J. Geom. Phys., 111, 169–193; 2018a, Entropy, 163, 1–26). This is a type of Lagrange–d’Alembert principle for the specific class of nonholonomic systems with nonlinear constraints of thermodynamic type, which are associated to the entropy production equation of the system. We illustrate our theory with some examples such as a cylinder-piston with ideal gas, an electric circuit with entropy production due to a resistor and an open piston with heat and matter exchange with the exterior.
Stochastic intracellular regulation can remove oscillations in a model of tissue growth
Authors: Banerjee M , Volpert V 
Published: June 2020

Abstract
The work is devoted to the analysis of cell population dynamics where cells make a choice between differentiation and apoptosis. This choice is based on the values of intracellular proteins whose concentrations are described by a system of ordinary differential equations with bistable dynamics. Intracellular regulation and cell fate are controlled by the extracellular regulation through the number of differentiated cells. It is shown that the total cell number necessarily oscillates if the initial condition in the intracellular regulation is fixed. These oscillations can be suppressed if the initial condition is a random variable with a sufficiently large variation. Thus, the result of the work suggests a possible answer to the question about the role of stochasticity in the intracellular regulation.
Presence of Antibodies Against Haemophilus influenzae Serotype a in Alaska Before and After the Emergence of Invasive Infections
Authors: McClure Max , Miernyk Karen , Bruden Dana , Rudolph Karen , Hennessy Thomas W , Bruce Michael G , Nolen Leisha D 
Published: June 2020

Abstract

Background
Haemophilus influenzae bacteria can cause asymptomatic carriage and invasive disease. Haemophilus influenzae serotype a (Hia) is an emerging cause of invasive disease in Alaska, with greatest burden occurring among rural Alaska Native (AN) children. The first case of invasive Hia (iHia) in Alaska was reported in 2002; however, it is unclear how long the pathogen has been in Alaska.

Methods
We quantified immunoglobulin G antibodies against Hia (anti-Hia) in 839 banked serum samples from Alaska residents, comparing antibody concentrations in samples drawn in the decades before (1980s and 1990s) and after (2000s) the emergence of iHia. We also assessed serum antibody concentration by age group, region of residence, and race.

Results
The anti-Hia was &gt;0.1 µg/mL in 88.1% (348 of 395) and 91.0% (404 of 444) of samples from the decades prior and after the emergence of Hia, respectively (P = .17). No significant differences in antibody levels were detected between people from rural and urban regions (1.55 vs 2.08 µg/mL, P = .91 for age ≥5) or between AN and non-AN people (2.50 vs 2.60 µg/mL, P = .26).

Conclusions
Our results are consistent with widespread Hia exposure in Alaska predating the first iHia case. No difference in Hia antibody prevalence was detected between populations with differing levels of invasive disease.
Suboptimal Biological Sampling as a Probable Cause of False-Negative COVID-19 Diagnostic Test Results
Authors: Kinloch Natalie N , Ritchie Gordon , Brumme Chanson J , Dong Winnie , Dong Weiyan , Lawson Tanya , Jones R Brad , Montaner Julio S G , Leung Victor , Romney Marc G , Stefanovic Aleksandra , Matic Nancy , Lowe Christopher F , Brumme Zabrina L 
Published: June 2020

AbstractFalse-negative severe acute respiratory syndrome coronavirus 2 test results can negatively impact the clinical and public health response to coronavirus disease 2019 (COVID-19). We used droplet digital polymerase chain reaction (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (ie, suspected false-negative test results) compared with a representative pool of 87 specimens submitted for COVID-19 testing. Our results support suboptimal biological sampling as a contributor to false-negative COVID-19 test results and underscore the importance of proper training and technique in the collection of nasopharyngeal specimens.
MRI safety management in patients with cardiac implantable electronic devices: Utilizing failure mode and effects analysis for risk optimization
Authors: Ryan James W , Murray Aoife S , Gilligan Paddy J , Bisset James M , Nolan Chris , Doyle Audrey , Emerson Barry , Galvin Joseph M , Murray John G 
Published: June 2020

Abstract

Introduction
Cardiac implantable electronic devices (CIEDs) are increasing in prevalence. Exposing patients with CIEDs to magnetic resonance imaging (MRI) can lead to adverse outcomes. This has led certain radiology departments to not accept MRI referrals related to patients with CIEDs. Patients with MR-conditional CIEDs can be safely scanned under specific conditions. Our institution has accepted such referrals since 2014. The aim of this study was to systematically identify and reduce risk in our CIED-MRI protocol using failure mode and effects analysis (FMEA).

Methods
A multidisciplinary FMEA team was assembled and included senior stakeholders from the CIED-MRI protocol. A process map was constructed followed by risk analysis and scoring. Targeted interventions were formulated and implemented; high-risk failure modes were prioritized. A new process map and protocol were drafted and repeat risk analysis was performed. Monitoring and re-evaluation of the CIED-MRI pathway were instigated at departmental quality assurance (QA) meetings.

Results
Interventions included direct CIED characterization using wireless technology pre-MRI, CIED programming and reprogramming in the MRI suite before and immediately after MRI reducing device downtime and continuous patient monitoring during MRI by a cardiac physiologist. The cumulative risk priority number (RPN) decreased from 1190 pre-FMEA to 492 post-FMEA.

Discussion
Despite the risk of exposing CIEDs to the MR environment, patients with MR-conditional CIEDs can be safely scanned with an appropriate multidisciplinary support. We found FMEA an indispensable tool in identifying and minimizing risk with no adverse events recorded since FMEA recommendations were implemented.
Rhythmic Flesh: How the Regulation of Bodily Rhythm Contributes to Spirituality in the Jesus Prayer, Medieval Dance, and African American Preaching
Authors: Eikelboom Lexi 
Published: June 2020

AbstractRecent scholarship on the concept of flesh in Christianity points to the body’s susceptibility to change and influence from material phenomena as well as from social and discursive forces. But what are the processes by which such forces shape the body? This article argues, by analyzing three Christian practices from distinctive contexts—the Hesychast Jesus Prayer, medieval liturgical dance, and African American preaching—that rhythm is a key to understanding these processes. Each practice forms a body capable of connecting with spiritual forces by leveraging the body’s material rhythms and their symbolic associations through a process called entrainment in relation to a particular social context. The analysis of each practice, therefore, contributes to our understanding of how material and nonmaterial factors work together in the process of religious formation by uncovering the ways in which rhythm connects both dimensions.
Mutations of Helicobacter pylori RdxA are mainly related to the phylogenetic origin of the strain and not to metronidazole resistance
Authors: Zhang Shuzhen , Wang Xiangyu , Wise Michael J , He Yongsheng , Chen Haiting , Liu Aijun , Huang Haiyan , Young Sylvia , Tay Chin Yen , Marshall Barry J , Li Xuehong , Chua Eng Guan 
Published: June 2020

Abstract

Objectives
Drug resistance of Helicobacter pylori is a major clinical problem worldwide. The objective of the present study was to investigate the prevalence of antibiotic-resistant H. pylori in the city of Shenzhen in China, as well as to identify the genetic mutations specifically associated with drug resistance rather than unrelated phylogenetic signals.

Methods
Antibiotic susceptibility testing was performed on 238 clinical strains successfully isolated from H. pylori-positive dyspeptic patients who underwent gastroscopy at the Department of Gastroenterology in Shenzhen People’s Second Hospital. Following WGS of all strains using Illumina technology, mutation and phylogenetic analyses were performed.

Results
The resistance rates were 84.9%, 35.3%, 25.2% and 2.1% for metronidazole, clarithromycin, ciprofloxacin and rifampicin, respectively. An A2143G conversion in the 23S rRNA gene was the primary mutation observed in clarithromycin-resistant strains, whilst N87K/I and D91G/N/Y in GyrA were detected in ciprofloxacin-resistant strains. In RdxA, our results demonstrated that only R16H/C and M21A are significant contributors to metronidazole resistance; there were 15 other sites, but these are phylogenetically related and thus unrelated to metronidazole resistance.

Conclusions
There is a high prevalence of metronidazole, clarithromycin and ciprofloxacin resistance and a low prevalence of rifampicin resistance in H. pylori from Shenzhen, China. Omission of phylogenetically related sites will help to improve identification of sites genuinely related to antibiotic resistance in H. pylori and, we believe, other species.
Laboratory Tests and Outcome for Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
Authors: Alnor Anne , Sandberg Maria B , Gils Charlotte , Vinholt Pernille J 
Published: June 2020

Abstract

Background
Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (COVID-19) and poses substantial challenges for healthcare systems. With a vastly expanding number of publications on COVID-19, clinicians need evidence synthesis to produce guidance for handling patients with COVID-19. In this systematic review and meta-analysis, we examine which routine laboratory tests are associated with severe COVID-19 disease.

Content
PubMed (Medline), Scopus, and Web of Science were searched until March 22, 2020, for studies on COVID-19. Eligible studies were original articles reporting on laboratory tests and outcome of patients with COVID-19. Data were synthesized, and we conducted random-effects meta-analysis, and determined mean difference (MD) and standard mean difference at the biomarker level for disease severity. Risk of bias and applicability concerns were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2.

Summary
45 studies were included, of which 21 publications were used for the meta-analysis. Studies were heterogeneous but had low risk of bias and applicability concern in terms of patient selection and reference standard. Severe disease was associated with higher white blood cell count (MD, 1.28 ×109/L), neutrophil count (MD, 1.49 ×109/L), C-reactive protein (MD, 49.2 mg/L), lactate dehydrogenase (MD, 196 U/L), D-dimer (standardized MD, 0.58), and aspartate aminotransferase (MD, 8.5 U/L); all p &lt; 0.001. Furthermore, low lymphocyte count (MD −0.32 × 109/L), platelet count (MD −22.4 × 109/L), and hemoglobin (MD, −4.1 g/L); all p &lt; 0.001 were also associated with severe disease. In conclusion, several routine laboratory tests are associated with disease severity in COVID-19.
Effects of Temperature on the Development and Fecundity of Atractomorpha Sinensis (Orthoptera: Pyrgomorphidae)
Authors: Li Wen-bo , Gao Yu , Cui Juan , Shi Shu-Sen 
Published: June 2020

Abstract
Over the recent years, Atractomorpha sinensis I. Bolivar, has emerged as an important agricultural pest in China. However, the biological characteristics of A. sinensis remain largely unknown, which can hinder the prediction of its population dynamics. Thus, understanding the impact of temperature on the developmental period of A. sinensis is crucial to predict its population dynamics. The biological characteristics of A. sinensis were systematically observed at five different temperatures (16, 20, 24, 28, and 32°C) using the age-stage, two-sex life table method. The results demonstrated that the developmental period, preadult time, adult longevity, adult preoviposition period, and total preoviposition period were significantly reduced when the temperature was elevated from 16 to 32°C. The developmental threshold temperatures of egg, nymph, preoviposition period, female adult, male adult, and generation were 9.14, 10.44, 12.53, 10.97, 12.47, and 10.58°C, respectively, with the corresponding effective accumulated temperatures of 452.31, 575.99, 169.58, 528.13, 340.81, and 1447.95 degree-days. With an increase in temperature, the intrinsic rate of increase (r) and finite rate of increase (λ) were increased, while the mean generation time (T) was shortened. The optimal values of net reproductive rate (R0= 73.00 offspring) and fecundity (244.55 eggs) were determined at 24°C. Similarly, the population trend index (I) of A. sinensis was found to be highest at 24°C. Our findings indicate that A. sinensis has the greatest rate of population growth at 24°C, which can provide a scientific basis for predicting the in-field population dynamics of A. sinensis.
Appendiculo-cecal intussusception: a case report and literature review
Authors: Agrawal Sunit , Khanal Bhawani , Gurung Roshan , Sah Suresh Prasad , Gupta Rakesh Kumar 
Published: June 2020

Abstract
Intussusception of the appendix is a rare disease that constitutes a diagnostic challenge to the surgeon. Intussusception is defined as the telescoping of a segment of the gastrointestinal tract into an adjacent one. We are reporting a case of a 14-year-old boy who presented in our institution with the features of acute appendicitis. On exploration appendiculo-cecal intussusception was found for which right hemicolectomy with ileotransverse colon anastomosis was done.
Arabidopsis MADS-box factor AGL16 negatively regulates drought resistance via stomatal density and stomatal movement
Authors: Zhao Ping-Xia , Miao Zi-Qing , Zhang Jing , Chen Si-Yan , Liu Qian-Qian , Xiang Cheng-Bin 
Published: June 2020

AbstractDrought is one of the most important environmental factors limiting plant growth and productivity. The molecular mechanisms underlying plant drought resistance are complex and not yet fully understood. Here, we show that the Arabidopsis MADS-box transcription factor AGL16 acts as a negative regulator in drought resistance by regulating stomatal density and movement. Loss-of-AGL16 mutants were more resistant to drought stress and had higher relative water content, which was attributed to lower leaf stomatal density and more sensitive stomatal closure due to higher leaf ABA levels compared with the wild type. AGL16-overexpressing lines displayed the opposite phenotypes. AGL16 is preferentially expressed in guard cells and down-regulated in response to drought stress. The expression of CYP707A3 and AAO3 in ABA metabolism and SDD1 in stomatal development was altered in agl16 and overexpression lines, making them potential targets of AGL16. Using chromatin immunoprecipitation, transient transactivation, yeast one-hybrid, and electrophoretic mobility shift assays, we demonstrated that AGL16 was able to bind the CArG motifs in the promoters of the CYP707A3, AAO3, and SDD1 and regulate their transcription, leading to altered leaf stomatal density and ABA levels. Taking our findings together, AGL16 acts as a negative regulator of drought resistance by modulating leaf stomatal density and ABA accumulation.
Chilli veinal mottle virus HCPro interacts with catalase to facilitate virus infection in Nicotiana tabacum
Authors: Yang Ting , Qiu Long , Huang Wanying , Xu Qianyi , Zou Jialing , Peng Qiding , Lin Honghui , Xi Dehui 
Published: June 2020

Abstract
Plant symptoms are derived from specific interactions between virus and host components. However, little is known about viral or host factors that participate in the establishment of systemic necrosis. Here, we showed that helper component proteinase (HCPro), encoded by Chilli veinal mottle virus (ChiVMV), could directly interact with catalase 1 (CAT1) and catalase 3 (CAT3) in the cytoplasm of tobacco (Nicotiana tabacum) plants to facilitate viral infection. In vitro, the activities of CAT1 and CAT3 were inhibited by the interaction between HCPro and CATs. The C-terminus of HCPro was essential for their interaction and was also required for the decrease of enzyme activities. Interestingly, the mRNA and protein level of CATs were up-regulated in tobacco plants in response to ChiVMV infection. Nicotiana tabacum plants with HCPro overexpression or CAT1 knockout were more susceptible to ChiVMV infection, which was similar to the case of H2O2-pre-treated plants, and the overexpression of CAT1 inhibited ChiVMV accumulation. Also, neither CAT1 nor CAT3 could affect the RNA silencing suppression (RSS) activity of HCPro. Our results showed that the interaction between HCPro and CATs promoted the development of plant systemic necrosis, revealing a novel role for HCPro in virus infection and pathogenicity.
Preoperative Chlorhexidine Gluconate Bathing on a Military Medical-Surgical Unit
Authors: Scallan Ross M , Gerathy Stephanie , Price Joyce , Lazarus Ann Marie , Metter E Jeffrey , Talbot Laura A 
Published: June 2020

ABSTRACT

INTRODUCTION AND SCOPE OF THE PROBLEM
Surgical site infections (SSIs) are associated with increased length of hospital stays, poor patient outcomes, and increased health care costs making prevention of SSI a high priority for the U.S. Military Health Care System. The focus of this project was to develop and pilot a preoperative antiseptic bathing regimen on an inpatient medical-surgical telemetry unit using 4% chlorhexidine gluconate (CHG), and to compare SSI rates with this new protocol to previous SSI rates on the unit.

MATERIALS AND METHODS
A literature review guided the development of the protocol and clinical question. A unit project was conducted using SSI rates from an inpatient military medical-surgical telemetry unit over 4 yr. From 2014 to 2016, 3 yr before implementing the protocol, a non-standardized CHG scrub was compared to 12 mo after implementing the standardized 4% CHG protocol in 2017 using up to four daily washings (three evenings and one morning surgery) on inpatient admissions to the unit. SSI rates were compared.

RESULTS
After implementing a 4-d preoperative bathing regimen with 4% CHG for patients scheduled for surgery, SSI rates decreased from an average rate of 0.0072 infections (7.2 infections per 1,000 surgeries) to 0.0035 infections (3.5 infections per 1,000 surgeries) in the subsequent year of data collection. Although not a statistically significant change, further analysis using a Bayesian Poisson regression model found an 84% probability the new protocol would lower SSI rate by 1 or more cases per 1,000 surgeries on this inpatient unit.

CONCLUSION
The findings suggest the proposed approach to control infection that may reduce the number of SSIs on a military medical-surgical unit, but this needs to be demonstrated through further longitudinal research on military surgical units.
Formation of aqua planets with water of nebular origin: effects of water enrichment on the structure and mass of captured atmospheres of terrestrial planets
Authors: Kimura Tadahiro , Ikoma Masahiro 
Published: June 2020

ABSTRACTRecent detection of exoplanets with Earth-like insolation attracts growing interest in how common Earth-like aqua planets are beyond the Solar system. While terrestrial planets are often assumed to capture icy or water-rich planetesimals, a primordial atmosphere of nebular origin itself can produce water through oxidation of the atmospheric hydrogen with oxidizing minerals from incoming planetesimals or the magma ocean. Thermodynamically, normal oxygen buffers produce water comparable in mole number equal to or more than hydrogen. Thus, the primordial atmosphere would likely be highly enriched with water vapour; however, the primordial atmospheres have been always assumed to have the solar abundances. Here we integrate the 1D structure of such an enriched atmosphere of sub-Earths embedded in a protoplanetary disc around an M dwarf of 0.3$\, \mathrm{M}_\odot$ and investigate the effects of water enrichment on the atmospheric properties with focus on water amount. We find that the well-mixed highly enriched atmosphere is more massive by a few orders of magnitude than the solar-abundance atmosphere, and that even a Mars-mass planet can obtain water comparable to the present Earth’s oceans. Although close-in Mars-mass planets likely lose the captured water via disc dispersal and photoevaporation, these results suggest that there are more sub-Earths with Earth-like water contents than previously predicted. How much water terrestrial planets really obtain and retain against subsequent loss, however, depends on efficiencies of water production, mixing in the atmosphere and magma ocean, and photoevaporation, detailed investigation for which should be made in the future.