bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociative identity disorder: a developmental perspective
Authors: Wilkinson Simon , DeJong Margaret 
Published: June 2020

SUMMARYDissociation is a common and often overlooked symptom in traumatised children. Although there is a lack of a scientific consensus as to the nature of dissociation and very limited research about dissociative identity disorder (DID) in children, the authors have seen children given this diagnosis recently referred to their clinic and are concerned about this practice and the parenting approaches that have ensued. The diagnosis of DID in children may be rare or of doubtful validity, but repeated traumatic experiences of an interpersonal nature can have a profound effect on a child's identity, memory and self-organisation. Furthermore, abuse and neglect can increase the risk of dissociative symptoms. This brief article considers dissociation in post-traumatic stress disorder, then outlines developmental factors hypothesised to be associated with dissociation in childhood and early adulthood. It warns that clinicians should keep an open mind about how dissociation may manifest transdiagnostically, and concludes with recommendations for further research.
Understanding the impact of fibroblast heterogeneity on skin fibrosis
Authors: Griffin Michelle F. , desJardins-Park Heather E. , Mascharak Shamik , Borrelli Mimi R. , Longaker Michael T. 
Published: June 2020

ABSTRACT
Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the body's natural wound healing process upon injury, or as a consequence of diseases such as systemic sclerosis. Skin fibrosis contributes to significant morbidity due to the prevalence of injuries resulting from trauma and burn. Fibroblasts, the principal cells of the dermis, synthesize extracellular matrix to maintain the skin during homeostasis and also play a pivotal role in all stages of wound healing. Although it was previously believed that fibroblasts are homogeneous and mostly quiescent cells, it has become increasingly recognized that numerous fibroblast subtypes with unique functions and morphologies exist. This Review provides an overview of fibroblast heterogeneity in the mammalian dermis. We explain how fibroblast identity relates to their developmental origin, anatomical site and precise location within the skin tissue architecture in both human and mouse dermis. We discuss current evidence for the varied functionality of fibroblasts within the dermis and the relationships between fibroblast subtypes, and explain the current understanding of how fibroblast subpopulations may be controlled through transcriptional regulatory networks and paracrine communications. We consider how fibroblast heterogeneity can influence wound healing and fibrosis, and how insight into fibroblast heterogeneity could lead to novel therapeutic developments and targets for skin fibrosis. Finally, we contemplate how future studies should be shaped to implement knowledge of fibroblast heterogeneity into clinical practice in order to lessen the burden of skin fibrosis.
A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors
Authors: Bajpai Anjali , Quazi Taushif Ahmad , Tang Hong-Wen , Manzar Nishat , Singh Virender , Thakur Ashwani , Ateeq Bushra , Perrimon Norbert , Sinha Pradip 
Published: June 2020

ABSTRACT
Peptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the Hippo pathway, YAP/Yorkie (Yki), has been implicated in many cancers, and is dependent on its interaction with the DNA-binding TEAD/Sd proteins via a large Ω-loop. In addition, the mammalian vestigial-like (VGLL) proteins, specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult Drosophila midgut. In addition, comparative proteomic analyses of peptide-treated and untreated tumors, together with chromatin immunoprecipitation analysis, reveal that integrin pathway members are part of the Yki-oncogenic network. Collectively, our findings establish Drosophila as a reliable in vivo platform to screen for cancer oral therapeutic peptides and reveal a tumor suppressive role for integrins in Yki-driven tumors.
This article has an associated First Person interview with the first author of the paper.
Effects of fragility fracture integrated rehabilitation management on mobility, activity of daily living and cognitive functioning in elderly with hip fracture
Authors: Aftab Anam , Awan Waqar Ahmed , Habibullah Shaista , Lim Jae Young 
Published: June 2020

Objective: To determine the effectiveness of Fragility Fracture Integrated Rehabilitation Management (FIRM) on mobility, activity of daily living and cognitive functioning in elderly with hip fracture.
Methods: A randomized control trial was conducted at Seoul National University Bundang Hospital, South Korea from August 2017 to January 2018. Patients of both genders with the age 65-95 years, diagnosed cases of hip fracture specifically fractures neck of femur, intertrochanteric, subtrochantric, patients who got bipolar hemiarthroplasty, total hip replacement arthroplasty, reduction and internal fixation were included in this study. A total of n=39 sample was collected through non probability convenience sampling technique and randomly divided into Fragility Integrated Rehabilitation Management (FIRM) group (n=20) and Conventional Physical therapy (CPT) group (n=19). The data was collected through KOVAL for walking ability, modified barthal index (MBI) for behaviors related to activities of daily living (ADLS) and mini mental status examination (MMSE) for cognitive functions at baseline on 2nd postoperative day and after 10th FIRM session on 15th postoperative day.
Results: The mean age of study participants was 82.07±6.00 years. The post intervention comparison did not show any significant difference (p>0.05) in walking ability, overall ADLs and cognitive functioning. But FIRM group showed significant improvement in stair climbing {0(5) ver. 2(7.5), p=0.049} and ambulation or walker use {8(5) ver. 2(4), p=0.037}, as compared to CPT group.
Conclusion: Both groups improved in indoor mobility with walker and crutches as well as activities of daily living. But FIRM showed more improving ambulation with walker and stair climbing. While cognitive functioning was observed only in FIRM group.
ClinicalTrials.gov Identifier: NCT03430193. https://clinicaltrials.gov/ct2/show/NCT03430193.
doi: https://doi.org/10.12669/pjms.36.5.2412
How to cite this:Aftab A, Awan WA, Habibullah S, Lim JY. Effects of fragility fracture integrated rehabilitation management on mobility, activity of daily living and cognitive functioning in elderly with hip fracture. Pak J Med Sci. 2020;36(5):965-970. doi: https://doi.org/10.12669/pjms.36.5.2412
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Frequency, Co-morbidities and outcome of acute kidney injury in elderly admitted patients
Authors: Mahmud Huma Mamun , Dastoor Hormatz Diar Dara 
Published: June 2020

Objectives: To analyse the frequency, co morbidities and outcome ofAcute Kidney Injury (AKI) in elderly patients.
Methods: This is an observational retrospective study performed in a secondary care Hospital located in Abu Dhabi. Study include adult patients admitted during 01st January 2018 till 31st December 2018. We uses KDIGO criteria of more than 26.5 micromol/L increase in serum creatinine within 48 hours or 1.5 times increase from baseline within seven days to define AKI. Patients were followed from admission till discharge from hospital either to Home, to other facility or death. Analysis was done on SPSS version 20.
Results: Total admissions for age 60 and above were 880. AKI was observed in 71 patients (8.0%). Most common co-morbidity found was hypertension being observed in 85.9%. Renal recovery was observed in 70.4% out of whom complete recovery was seen in only 32.4% and rest shows partial recovery. Hemodialysis was required in 16.90% and death results in 22.5% of our study patients.
Conclusion: AKI is frequent among elderly admitted patients, commonest co- morbidity in these patients is hypertension. Outcome of AKI in elderly patients is poor with death in 22% of our patients.
doi: https://doi.org/10.12669/pjms.36.5.2429
How to cite this:Mahmud HM, Dastoor HDD. Frequency, Co-morbidities and outcome of acute kidney injury in elderly admitted patients. Pak J Med Sci. 2020;36(5):920-924. doi: https://doi.org/10.12669/pjms.36.5.2429
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Science and Sustainability in Food
Authors: Vaz A. , Trindade A.P. , Pedro P. , Henriques C. , Sequeira L. , Zaragoza M. , Viegas M. 
Published: June 2020

In this project we studied the aquaponics system that allows the simultaneous production of some species of vegetables and fish. In this way, it allows the identification of the circular economy system, present in this production circuit. When feeding fish in an aquarium, the excrement produced by them is rich in nutrients that feed the plants that, in turn, filter the water for the fish. With a water pump, that keeps the water in circulation, a continuous closed circuit is achieved. We concluded that, with water and energy savings, without using phytopharmaceuticals, and with naturally occurring processes, an economy of means and the food quality is guaranteed: plants and fish. In studying this, we looked for ways to obtain the material, we do the installation and maintenance of the system, performed daily tasks and monitor the growth of plants and animals, managing to use aromatic herbs for the school bar and also divulge it.
Trash @ School
Authors: Coelho A. , Moleiro M. C. 
Published: June 2020

After the inauguration of a local park located next to Venda do Pinheiro school, students quickly began to encounter problems of misuse. Specifically, they complained about garbage scattered in a park that was still new: cigarette butts in the skate and sports areas, dog waste, and other situations. The aim of this project was to challenge students to find solutions to make park users aware of how to improve their behavior. After identifying this common problem, each group had to design a multimedia product to raise public awareness, either by creating a video campaign or designing a piece of urban furniture using 3D modeling and printing.
Municipal Young Assembly
Authors: Paixão H. , Romeiro S. 
Published: June 2020

This project results from the need to encourage young people to actively participate in the life of the Municipality. In the 2018/2019 academic year, the theme “Climate change: reversing global warming” was worked on in almost all curricular areas, in two 8th grade classes of the school. The classes elected their own "Young Municipal Deputies". Throughout the project, students were prepared for the final session, where each school represented a party and allparties presented and defended their proposals, to all the Assembly.
Healthy Eating Habits
Authors: Martins L. , Bruno G. 
Published: June 2020

This project focuses on the theme of healthy eating habits and is being developed by students from class 8.ºD and under the scope of our school’s social inclusion program. Two questionnaires were applied, one on food and the other on hydration in a school environment, to all classes in the 7th grade and class 8.ºD. In order to alert the school community to the needfor good hydration, the class 8.ºD organized a tasting session on flavoured water. In collaboration with the project, the nurse from the school health centre gave two lectures on healthy eating habits. Schools’ shutdown due to Covid-19 pandemic did not allow more sessions to be held, nor to share with the community the questionnaires’ results. Nevertheless, one of the projects main goals is to implement in the school flavoured water dispensers, to encourage students to drink more water.
Message in a Bottle
Authors: Matos M. M. 
Published: June 2020

This project aims to develop a culture of affection, with a view to humanization and the development of the feeling of belonging in the relations of the school community, based on the exercise of citizenship. Messages, prepared by students in Portuguese classes, were placed in reused plastic bottles, decorated for this purpose in Visual Education classes. The messages were translated by students to English, French and German classes and by various elements of the school community, totalling nine different languages. The bottles were successfully delivered by the school to health care institutions. This project has been implemented since the 2015-2016, and 416 messages were distributed to 20 stakeholders. We want messages to be sent to as many people as possible, both at regional, national and international level.
wasH
Authors: Azevedo M. 
Published: June 2020

In a bathroom, practically everything is contaminated. The simple act of washing your hands after use can prevent contamination and decrease the appearance of some diseases. But there are few people who carry out this simple action. wasH is an awareness campaign designed by students in professional health education aimed not only at the entire school population butalso at the entire population of Entroncamento. Some workshops were held and there are already many restaurants and coffee shops participating in the campaign.
We are all School
Authors: Sousa A. N. , Couto P. A. 
Published: June 2020

The project “We are all school” aimed to break down barriers between the school and the community, to convey the idea that we all have something to add to the school, as we are all educational agents. Our intention was to give more visibility to the activities that the school develops with the community in general. As this community is made up of people from different parts of the world, with diverse cultures and knowledge, we set out to look for their experiences and knowledge so that the school could benefit from the richness of this diversity. We also set out to involve the whole community more actively, valuing all the knowledge that could be carried to benefit the full learning path of students, regardless of their origin or social position.
Small bowel knots
Authors: Beg MY , Bains L , Lal P , Maranna H , Kumar N P 
Published: June 2020

Introduction Intertwining of bowel loops to form a knot is very rare cause of intestinal obstruction. Among intestinal knots, ileoileal knotting is the most rare, with only a handful of cases reported in literature. We present a rare case of ileoileal knotting and review of small bowel knots. The aim of this review was to summarise the existing evidence on small bowel knots and to postulate the possible mechanisms for knotting. Methods A systematic search was conducted for literature published up to December 2019 using MEDLINE, PubMed and Google Scholar databases, together with the references of the full-text articles retrieved. Papers with case reports of small bowel knots were considered to be eligible for inclusion in the review. Findings A total of 14 case reports were evaluated. There was no clear predilection for age or sex. Mostly cases were from Asia and Africa with no cases from the West. The presenting complaints were abdominal pain (93%), vomiting (64%), abdominal distention (57 %) and obstipation (43%). The bowel was gangrenous in 78% of cases. All underwent exploration, with the majority requiring resection and anastomosis of the involved segment. Conclusion Ileoileal knotting is a very rare cause of intestinal obstruction. Possible mechanisms include loaded bowel with longer mesentery, vigorous peristalsis, single bulky meal, pregnancy and intussusception. The condition is extremely difficult to diagnose preoperatively and it is usually diagnosed intraoperatively. The standard of treatment is resection of gangrenous part and anastomosis.
Should the rectal defect be sutured following TEMS/TAMIS carried out for neoplastic rectal lesions? A meta-analysis
Authors: Khan K , Hunter IA , Manzoor T 
Published: June 2020

Introduction Management of the rectal defect following transanal endoscopic microsurgery (TEMS) or minimally invasive surgery (TAMIS) carried out for excision of neoplasm in the lower rectum is controversial. We aimed to extract evidence by carrying out a meta-analysis to compare the peri- and postoperative outcomes following rectal neoplasm excision carried out by TEMS and/or TAMIS, whereby the defect is either sutured or left open. Methods A literature search of Ovid MEDLINE and EMBASE was performed. Full-text comparative studies published until November 2019, in English and of adult patients, whereby TEMS or TAMIS was undertaken for rectal neoplasms were included. The main outcome measures were postoperative bleeding, infection, operative time and hospital stay. Findings Three studies (one randomised controlled trial and two comparative case series) yielded 555 cases (283 in the sutured group and 272 in the open group). The incidence of postoperative bleeding was higher and statistically significant (p = 0.006) where the rectal defect was left open following excision of the neoplasm (19/272, 6.99% vs 6/283, 2.12%). There was no statistical difference between the sutured and open groups regarding infection (p = 0.27; (10/283, 3.53% vs 5/272, 1.84%, respectively), operative time (p = 0.15) or length of stay (p = 0.67). Conclusion Suturing the rectal defect following excision of rectal neoplasm by TEMS/TAMIS reduces the incidence of postoperative bleeding in comparison to leaving the defect open. However, suturing makes the procedure slightly longer but there was no statistical difference between both groups when postoperative infection and length of hospital stay were compared.
Real-time assessment of learning curve for robot-assisted laparoscopic prostatectomy
Authors: Tamhankar A , Spencer N , Hampson A , Noel J , El-Taji O , Arianayagam R , McNicholas T , Boustead G , Lane T , Adshead J , Vasdev N 
Published: June 2020

IntroductionThe learning curves analysed to date for robot-assisted laparoscopic prostatectomy are based on arbitrary cut-offs of the total cases.MethodsWe analysed a large dataset of robot-assisted laparoscopic prostatectomies from a single centre between 2008 and 2019 for assessment of the learning curve for perioperative outcomes with respect to time and individual cases.ResultsA total of 1,406 patients were evaluated, with mean operative time 198.08 minutes and mean console time 161.05 minutes. A plot of operative time and console time showed an initial decline followed by a near-constant phase. The inflection points were detected at 1,398 days (308th case) for operative time and 1,470 days (324th case) for console time, with a declining trend of 8.83 minutes and 7.07 minutes, respectively, per quarter-year (p<0.001). Mean estimated blood loss showed a 70.04% reduction between the start (214.76ml) and end (64.35ml) (p<0.001). The complication rate did not vary with respect to time (p=0.188) or the number of procedures (p=0.354). There was insufficient evidence to claim that the number of operations (p=0.326), D’Amico classification (p=0.114 for intermediate versus low; p=0.158 for high versus low) or time (p=0.114) was associated with the odds of positive surgical margins.ConclusionsIt takes about 300 cases and nearly 4 years to standardise operative and console times, with a requirement of around 80 cases per annum for a single surgical team in the initial years to optimise the outcomes of robot-assisted laparoscopic prostatectomy.
Acute right iliofemoral deep vein thrombosis mimicking acute appendicitis in the postpartum period: a case report
Authors: Karaisli S , Selcuk E 
Published: June 2020

The risk of venous thromboembolism increases during pregnancy and postpartum. The incidence in the first six weeks following delivery is approximately 0.15%. Deep vein thrombosis may present with acute appendicitis-like symptoms such as right iliac fossa pain, nausea and vomiting. A 22-year-old woman was admitted with complaints of abdominal pain and vomiting 20 days after spontaneous vaginal delivery. Physical examination and radiological findings were compatible with acute appendicitis. Preoperative re-examination and re-evaluation of computed tomography revealed concomitant deep vein thrombosis on the right side. The patient underwent laparotomy and a normal appendix and ovaries were found. She had an uneventful recovery. Anticoagulant treatment was administered for six months. Early and correct diagnosis should be established to avoid complications of deep vein thrombosis and prevent unnecessary surgical interventions. Physicians should be aware of deep vein thrombosis in women who present acute appendicitis-like symptoms, especially during pregnancy and in the postpartum period.
High-resolution quantitative phase imaging based on a spatial light modulator and incremental binary random sampling
Authors: Wang Zhao , Wei Gong-Xiang , Ge Xiao-Lu , Liu Hui-Qiang , Wang Ben-Yi 
Published: June 2020

We propose a single-beam high-resolution quantitative phase imaging method based on a spatial light modulator (SLM) and an incremental binary random sampling (IBRS) algorithm. In this method, the image of the test object presents on the image sensor through an optical microscopy system composed of an objective lens and a collimating lens. A transmittance SLM displaying a group of well-designed IBRS patterns is inserted in the optical microscopy system to modulate the object wavefront. The phase information of the object image can be quantitatively retrieved from the recorded intensities using the IBRS algorithm and the amplitude obtained directly from the diffraction intensity. The IBRS algorithm employed in our method has higher accuracy for phase retrieval compared with our previously proposed complementary random sampling algorithm, which is confirmed by simulations. Further, we demonstrate experimentally the feasibility of our method through several examples: phase imaging of immersion oil droplets with a diffraction-limited lateral resolution of 1.54 µm and a few microbiological specimens with 0.70 µm. Experimental results reveal that our proposed method provides a feasible single-beam technique for quantitative phase imaging with a high spatial resolution.