bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support and resilience in persons with severe haemophilia: An interpretative phenomenological analysis
Authors: Ratajová Kateřina , Blatný Jan , Poláčková Šolcová Iva , Meier Zdeněk , Horňáková Tekla , Brnka Robert , Tavel Peter 
Published: April 2020

AbstractIntroductionHaemophilia is a hereditary haemorrhagic disorder characterized by deficiency or dysfunction of coagulation factors. Recurrent joint and muscle bleeds lead to progressive musculoskeletal damage. Haemophilia affects patients physically but also socially and psychologically. Traumatic experiences, chronic stress and illnesses can lead to mental disorders, but many persons with haemophilia maintain a highly positive outlook.AimTo explore qualitatively which coping mechanisms persons with haemophilia use and in what way they help them to live with their diagnosis.MethodsWe recruited five adults with haemophilia and conducted semi‐structured face‐to‐face interviews. Transcripts were analysed using interpretative phenomenological analysis (IPA).ResultsTwo core themes emerged from the analysis: social support as an external factor and resilience as an internal factor of coping with the disease. Persons with haemophilia usually need help with health‐related complications, and this affects the social support they require. Their wider support network tends to involve family and friends but also healthcare professionals and other specialists. This network provides practical help but also functions as an important psychological protective factor. An unexpected finding was that persons with haemophilia want not only to receive support but are also keen to offer support to others.ConclusionThese findings can help identify persons who provide most support to people suffering from haemophilia. Haemophilic centres should include in their teams psychologists and social workers and offer individual and group therapy to their clients, group meetings for friends and families of persons with haemophilia, provide learning resources to teachers aiming to incorporate children with haemophilia in their peer group, and organize Balint groups for physicians, psychologists and other healthcare professionals.
Production of a potential collagenolytic protease by nejayote fermentation with Aspergillus oryzae
Authors: Rocha‐Pizaña María del R. , Chen Wei Ning , Lee Jaslyn J. L. , Buitimea‐Cantúa Nydia E. , González‐Nimi Emiko , Gutierrez‐Uribe Janet A. 
Published: April 2020

SummaryNejayote is the wastewater obtained from maize lime cooking. It was used for Aspergillus oryzae growth and enzyme production. Protein production and collagenolytic activity were evaluated to test the effects of pH, spore inoculum and nejayote content in a 33 factorial design. No collagenolytic activity was observed in the supernatant of the fermentation without nejayote. Using nejayote at 5% increased 1.5 times the fungus growth in comparison with nejayote 1% and 3%; and the maximum collagenolytic activity was reached after 3 days at pH 8 (P < 0.05). After sequencing, a 32 kDa alkaline protease was identified. Along with the alkaline conditions produced by the inclusion of nejayote solids, this waste is an important source of carbohydrates that improved the growth of A. oryzae to produce a protease that has the potential to break collagen. This permits a prospective revalorisation of a waste material to get a product with multiple biotechnological uses.
Technological, nutritional and sensorial characteristics of wheat bread fortified with calcium salts
Authors: Rossi Matías G. , Soazo Marina , Piccirilli Gisela N. , Llopart Emilce E. , Revelant Gilda C. , Verdini Roxana A. 
Published: April 2020

SummaryThe aim of this paper was to carry out a comprehensive study of wheat flour breads fortified with different sources of calcium, which includes: technological, nutritional and sensorial characteristics. Calcium salts (lactate: LA, carbonate: CA, and citrate: CI) at two fortification levels (20% and 50%) were analysed. Only the LA fortified breads were harder with lower specific volume and the LA 50% showed the higher chewiness value. The crust colour of the CI 50% breads presented the lower browning index. In vitro nutritional studies showed that calcium content on digest and dialysate was significantly higher in all fortified breads. The CI 20% and all the 50% fortifications showed a better contribution of bioaccessible calcium. Sensorial general quality was not significantly different between fortified and Control breads.
Time, Space, Confucianism and Careers: A Contextualized Review of Careers Research in China – Current Knowledge and Future Research Agenda
Authors: Yao Christian , Duan Zheng (Daniel) , Baruch Yehuda 
Published: April 2020

AbstractCareer studies attract significant attention, but most of the theories and concepts were developed and tested in Western contexts. Based on a systematic review and analysis of 95 articles published in the field of careers that focus on China in the period between 1991 and 2017, this paper identifies emerging trends and outlines a profile of the current development of careers research in the Chinese context. Using a time and space analytical framework, the review evaluates the theoretical and empirical career lenses embedded in the unique Chinese cultural, institutional and organizational contexts and confirms that research on Chinese careers is significantly underdeveloped. Through a theoretical lens of Confucianism, we propose a need to consider context‐specific factors, in particular time and space, when conducting Chinese careers research, and present implications for future research on careers in China.
Hunger in the household: Food insecurity and associations with maternal eating and toddler feeding
Authors: Armstrong Bridget , Hepworth Allison D. , Black Maureen M. 
Published: April 2020

SummaryBackgroundResearch is needed to identify how food insecurity affects maternal eating behavior and child feeding practices, factors that may pose intergenerational risks for obesity.ObjectivesThis longitudinal study investigated whether maternal restrained eating mediated the association between household food insecurity and feeding practices.MethodsParticipants included 277 WIC‐eligible mothers (69% below the poverty line, 70% African American) and their toddlers (Mage= 20.11 months, SD = 5.50) participating in a childhood obesity prevention trial. Maternal reports of household food insecurity, restrained eating, and child feeding practices (restrictive and responsive) were collected at baseline, 6 and 12 months and analyzed using multilevel mediation.ResultsForty percent of mothers reported some degree of household food insecurity over 12 months. Within‐person analyses showed that relative increases in household food insecurity were indirectly related to increases in restrictive and decreases in responsive child feeding practices, mediated through increases in mothers' own restrained eating.ConclusionsRelative changein household food insecurity (rather than overall severity) appears to have indirect effects on toddler feeding practices, through mothers' own eating. Stable household food security without transient food insecurity may improve health and wellbeing for both mothers and children.
Familiarity plays a small role in noun comprehension at 12–18 months
Authors: Garrison Hallie , Baudet Gladys , Breitfeld Elise , Aberman Alexis , Bergelson Elika 
Published: April 2020

AbstractInfants amass thousands of hours of experience with particular items, each of which is representative of a broader category that often shares perceptual features. Robust word comprehension requires generalizing known labels to new category members. While young infants have been found to look at common nouns when they are named aloud, the role of item familiarity has not been well examined. This study compares 12‐ to 18‐month‐olds’ word comprehension in the context of pairs of their own items (e.g., photographs of their own shoe and ball) versus new tokens from the same category (e.g., a new shoe and ball). Our results replicate previous work showing that noun comprehension improves rapidly over the second year, while also suggesting that item familiarity appears to play a far smaller role in comprehension in this age range. This in turn suggests that even before age 2, ready generalization beyond particular experiences is an intrinsic component of lexical development.
Permeability spectra of planar M‐type barium hexaferrites with high Snoek’s product by two‐step sintering
Authors: Li Qifan , Chen Yajie , Yu Chengju , Qian Kun , Harris Vincent G. 
Published: April 2020

AbstractHigh‐frequency ferrite ceramics exhibiting high permeability and low magnetic loss have been recently attracting more and more attention owing to the rapid development of modern communication technologies. It is known that the magnetic performance of ferrites is strongly associated with the morphology of their polycrystalline structure. In this work, we focus on the control of grain growth and densification process for planar Co‐Ti doped M‐type barium hexaferrites, BaCoxTixFe12‐xO19, by one‐step sintering (OSS) and two‐step sintering (TSS) techniques. Experimental results indicate that a uniform and fine‐grained microstructure is achieved by the TSS method. More importantly, the ferrites prepared by TSS demonstrate high permeability (µ' = 18‐20), low magnetic loss (tan δm = 0.1‐0.3), and high Snoek's product (>25 GHz) in the frequency range of 100‐400 MHz. By fitting experimental data, we have determined that low magnetic loss is derived from the small damping coefficient of spin rotation in terms of Kittel's theory. Therefore, the TSS technique provides an effective and efficient approach to prepare planar BaM hexaferrite materials for ultra‐high frequency (UHF) communication devices requiring low loss and high Snoek's product.
Geniposide alleviates non‐alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways
Authors: Shen Bingyu , Feng Haihua , Cheng Jiaqi , Li Zheng , Jin Meiyu , Zhao Lilei , Wang Qi , Qin Haiyan , Liu Guowen 
Published: April 2020

AbstractNon‐alcohol fatty liver disease (NAFLD) is a common disease which causes serious liver damage. Geniposide (GEN), a kind of iridoid glycoside extracted from Gardenia jasminoides fruit, has many biological effects, such as resistance to cell damage and anti‐neurodegenerative disorder. Lipid accumulation was obvious in tyloxapol‐induced liver and oil acid (OA) with palmitic acid (PA)‐induced HepG2 cells compared with the control groups while GEN improved the increasing conditions. GEN significantly lessened the total cholesterol (TC), the triglyceride (TG), low‐density lipoprotein (LDL), very low‐density lipoprotein (VLDL), myeloperoxidase (MPO), reactive oxygen species (ROS) and increased high‐density lipoprotein (HDL), superoxide dismutase (SOD) to response the oxidative stress via activating nuclear factor erythroid‐2–related factor 2 (Nrf2), haeme oxygenase (HO)‐1 and peroxisome proliferator‐activated receptor (PPAR)α which may influence the phosphorylation of adenosine 5’‐monophosphate–activated protein kinase (AMPK) signalling pathway in mice and cells. Additionally, GEN evidently decreased the contents of sterol regulatory element‐binding proteins (SREBP)‐1c, phosphorylation (P)‐mechanistic target of rapamycin complex (mTORC), P‐S6K, P‐S6 and high mobility group protein (HMGB) 1 via inhibiting the expression of phosphoinositide 3‐kinase (PI3K), and these were totally abrogated in Nrf2−/− mice. Our study firstly proved the protective effect of GEN on lipid accumulation via enhancing the ability of antioxidative stress and anti‐inflammation which were mostly depend on up‐regulating the protein expression of Nrf2/HO‐1 and AMPK signalling pathways, thereby suppressed the phosphorylation of mTORC and its related protein.
Heterotopic ossification of tendon and ligament
Authors: Zhang Qiang , Zhou Dong , Wang Haitao , Tan Jun 
Published: April 2020

AbstractMuch of the similarities of the tissue characteristics, pathologies and mechanisms of heterotopic ossification (HO) formation are shared between HO of tendon and ligament (HOTL). Unmet need and no effective treatment has been developed for HOTL, primarily attributable to poor understanding of cellular and molecular mechanisms. HOTL forms via endochondral ossification, a common process of most kinds of HO. HOTL is a dynamic pathologic process that includes trauma/injury, inflammation, mesenchymal stromal cell (MSC) recruitment, chondrogenic differentiation and, finally, ossification. A variety of signal pathways involve HOTL with multiple roles in different stages of HO formation, and here in this review, we summarize the progress and provide an up‐to‐date understanding of HOTL.
Efficacy and safety of panitumumab alone or in association with radiotherapy in unresectable cutaneous squamous cell carcinoma
Authors: Hourbeigt K. , Ehret M. , Visseaux L. , Durlach A. , Petit A. , Sanchez J. , Grange‐Prunier A. , Barbe C. , Servagi‐Vernat S. , Grange F. 
Published: April 2020

AbstractBackgroundThe prognosis of unresectable cutaneous squamous cell carcinomas is very poor.ObjectiveTo evaluate the efficacy and safety of panitumumab alone or in association with radiotherapy in the treatment of unresectable cutaneous squamous cell carcinoma.MethodsThis was a monocentre retrospective study of all consecutive patients having received at least two courses of panitumumab, alone or in association with radiotherapy, between 2016 and 2019. The primary endpoint was the rate of best overall response, evaluated according to the RECIST 1.1 criteria. The secondary endpoints were the response and disease control rates at 6 weeks and 6 months, progression‐free survival, overall survival and safety.ResultsA total of 25 patients were included; their median age was 86 years, and 17 (86%) had a WHO performance status over 2. The best overall response rate was 52%, including four complete responses (16%) and nine partial responses (36%). All patients with complete response and five out of nine patients with partial response had received concurrent radiotherapy, in most cases in moderate to low doses (<40 Gray, 67%). The response rates at 6 weeks and 6 months were 12% and 28%, respectively. The control rates at 6 weeks and 6 months were 84% and 32%, respectively. Median progression‐free survival was 6.9 months, and median overall survival was 10.5 months. Grade 3 side‐effects, mostly dermatological, occurred in 16 patients (64%).ConclusionThese results suggest that panitumumab remains pertinent in the treatment of unresectable cutaneous squamous cell carcinoma, in particular in association with radiotherapy, despite recent advances with anti‐PD‐1 antibodies. It presents several advantages: it can be used in very elderly or feeble patients, it does not provoke anaphylactic or other irreversible or life‐threatening side‐effects, and our study observed some long‐term responses. Further prospective investigation of anti‐EGFR antibodies, in association with anti‐PD‐1 antibodies and/or chemotherapy, should be conducted.
Identification of male heterogametic sex‐determining regions on the Atlantic herring Clupea harengus genome
Authors: í Kongsstovu Sunnvør , Dahl Hans Atli , Gislason Hannes , Homrum Eydna , Jacobsen Jan Arge , Flicek Paul , Mikalsen Svein‐Ole 
Published: April 2020

AbstractThe sex determination system of Atlantic herring Clupea harengus L., a commercially important fish, was investigated. Low coverage whole‐genome sequencing of 48 females and 55 males and a genome‐wide association study revealed two regions on chromosomes 8 and 21 associated with sex. The genotyping data of the single nucleotide polymorphisms associated with sex showed that 99.4% of the available female genotypes were homozygous, whereas 68.6% of the available male genotypes were heterozygous. This is close to the theoretical expectation of homo/heterozygous distribution at low sequencing coverage when the males are factually heterozygous. This suggested a male heterogametic sex determination system in C. harengus, consistent with other species within the Clupeiformes group. There were 76 protein coding genes on the sex regions but none of these genes were previously reported master sex regulation genes, or obviously related to sex determination. However, many of these genes are expressed in testis or ovary in other species, but the exact genes controlling sex determination in C. harengus could not be identified.
Gill amoebae from freshwater rainbow trout (Oncorhynchus mykiss): In vitro evaluation of antiparasitic compounds againstVannellasp.
Authors: Jensen Hannah Malene , Karami Asma Mohammad , Mathiessen Heidi , Al‐Jubury Azmi , Kania Per Walter , Buchmann Kurt 
Published: April 2020

AbstractGill parasitic infections challenge farming of rainbow trout (Oncorhynchus mykiss,Walbaum) in freshwater facilities. Apart from flagellates (Ichthyobodo,(Pinto) and ciliates (Ichthyophthirius(Fouquet), Ambiphrya(Raabe),Apiosoma(Blanchard),Trichodinella(Sramek‐Husek) andTrichodina(Ehrenberg)), we have shown that amoebae are prevalent in Danish trout farms. Gills were isolated from farmed rainbow trout in six fish farms (conventional and organic earth pond and recirculated systems) and placed on non‐nutrient agar (NNA) moistened with modified Neff's amoeba saline (AS) (15°C). Gill amoebae from all examined fish colonized the agar and were identified based on morphological criteria showing species within the generaTrinema(Dujardin) (family Trinematidae),Vannella(Bovee) (family Vannellidae). In addition, hartmannellid amoebae were recorded. We established a monoculture ofVannellasp., confirmed the genus identity by PCR and sequencing and performed an in vitro determination of antiparasitic effects (dose–response studies) of various compounds including sodium chloride (NaCl), hydrogen peroxide, peracetic acid, formalin, aqueous garlic and oregano extracts and aPseudomonasH6 surfactant. All amoebae were killed in concentrations of 16.90 mg/ml (garlic), 17.90 mg/ml (oregano), NaCl (7.5 mg/ml), hydrogen peroxide (100 µg/ml), peracetic acid (0.03 µg/ml), formaldehyde (25 µg/ml) and thePseudomonasH6 surfactant (250 µg/ml).
Intensification of the triticale (× triticosecale Wittmac) hydration process using periodic operation
Authors: de Oliveira Lucas C. , de Matos Jorge Luiz M. , Jorge Regina M. M. 
Published: April 2020

AbstractThe new triticale cultivars caught the industries attention due to excellent nutritional composition. The rare literature regarding hydration process intensification, coupled with the lack of research regarding the hydration of triticale, motivated this research. This study aimed to evaluate the hydration process intensification of two cultivars triticale. The isothermal operation was done at temperature range of 20–40°C and compared to process intensification using amplitude of 10°C and half‐cycle of 15 min, at an average temperature of 30°C. In parallel to hydration process, the fit of the Peleg model to the experimental data was evaluated and the morphology of the starch granules was observed using SEM images. The hydration temperature did not affect the starch grains morphology. The hydration kinetic was obtained applying the Peleg model, which exhibited a good fit for both operations. The model parameters values (K1 and K2) indicated that the periodic hydration process exhibits a greater water absorption rate and a final higher moisture for both cultivars. The periodic operation reduced the energy consumption of hydration process in approximately 50%, this reduction proves that this operation with temperature modulation is a process strategy highly promising for grains hydration process intensification.Practical ApplicationsTriticale is a hybrid grain that has been drawing attention from various industrial sectors for application in the production of malt, packages, various foods, and ethanol. Thus, an understanding of the hydration kinetics of triticale that has not yet been described in the literature, together with the morphology of the starch grains, is of supreme importance. In view of this, the present work presents the water absorption of triticale when submitted to periodic operation by means of temperature modulation, with the aim of intensifying the hydration process as compared to the conventional operation, in addition to observing any potential morphological alterations in the starch grains. These results assist in the monitoring and control of industrial and academic processes, providing a better understanding of the hydration mechanisms and the morphology of the starch granules of the triticale for a possible inclusion of this cereal in new applications and product development.
The Second Victim Phenomenon: How Are Midwives Affected?
Authors: McDaniel Linda R. , Morris Charlotte 
Published: April 2020

AbstractPerinatal care providers are likely to encounter adverse events such as intrapartum emergencies, traumatic births, or maternal or fetal deaths. As a result of being directly or indirectly involved in an adverse event, health care providers can be considered second victims. The experience of the second victim phenomenon can lead to significant physical, psychological, and psychosocial sequelae that can negatively impact the provider's personal and professional life for either a short or long duration of time. When health care providers experience an adverse event, they may manifest symptoms of guilt, shame, blame, flashbacks, nightmares, insomnia, isolation, helplessness, and hopelessness, thereby becoming the second victim. Following an adverse event, health care providers who experience second victim phenomenon experience stages of recovery that influence subsequent professional and personal well‐being. Persons who experience the second victim phenomenon can incorporate self‐care behaviors to assist with recovery. Health care organizations have a responsibility to implement efficacious support programs that promote the provider's recovery and a return to safe and full function in the workplace.
Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies
Authors: Rasoanirina Bakoliarisoa Nivomalala Voahangy , Lassoued Mohamed Ali , Miladi Karim , Razafindrakoto Zoarilala , Chaâbane-Banaoues Raja , Ramanitrahasimbola David , Cornet Muriel , Sfar Souad 
Published: April 2020

Abstract

Objective
This study investigates the effectiveness of self-nanoemulsifying drug delivery system (SNEDDS) in improving voriconazole transcorneal permeability.

Methods
Voriconazole-SNEDDS was prepared with isopropyl myristate, PEG 400, Tween 80® and Span 80® and was subjected for physicochemical characterization after reconstitution with NaCl 0.9% (1/9; v/v). In-vitro antifungal activity was assessed and compared with the marketed formulation. In-vivo studies, namely ocular irritation test via modified Draize test and pharmacokinetic study, were investigated using rabbit as animal model.

Key findings
Voriconazole-SNEDDS presented a droplet size of 21.353 ± 0.065 nm, a polydispersity index of 0.123 ± 0.003, a pH of 7.205 ± 0.006 and an osmolarity of 342.667 ± 2.517 mOsmol/l after reconstitution with NaCl 0.9%. Voriconazole-SNEDDS minimum inhibitory concentration (MIC90) was similar to the one of marketed formulation for Candida species while it was significantly lower (P &lt; 0.001) for Aspergillus fumigatus. Draize test revealed that Voriconazole-SNEDDS was safe for ocular administration. Voriconazole maximum concentration (5.577 ± 0.852 µg/ml) from SNEDDS was higher than marketed formulation (Cmax = 4.307 ± 0.623 µg/ml), and the Tmax was delayed to 2 h. The area under the concentration–time curve value of Voriconazole-SNEDDS was improved by 2.419-fold.

Conclusion
Our results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery and this encourages further clinical studies.