bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients
Authors: Ibrahim Hassan M. , El-Taieb Moustafa A. , Hassan Mohammed H. , Mohamed Abd Allah E. , Kotop Ebtihal A. , Abd-ellah Osama H. , Hegazy Eisa M. 
Published: December 2020

AbstractAtopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. There are a lot of evidences on the importance of vitamin D and house dust mite (HDM) allergens in the etiology and course of AD. The objectives of this study are to evaluate the relation between vitamin D3 level and house dust mites (HDM) Dermatophagoidspecies sensitization in pathogenesis of atopic dermatitis. Cross-sectional design study was conducted on 50 atopic dermatitis patients. Blood analysis were done to determine level of vitamin D3, total IgE by fluorescent immunoassay & specific IgE for HDM (d1, d2) & other inhalant allergens by ELISA test. There was significant high negative correlation with the specific IgE for HDM (r =  −0. 62, p < 0.001) and vitamin D3. & there was non-significant minimal negative correlation with the specific IgE and other inhalant allergens (r = − 0.10, p > 0.05). There was a statistically significant relation between level of vitamin D3 and atopic dermatitis severity and sensitization to HDM and other allergens.
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population
Authors: Walsh Sandra , Izquierdo-Serra Mercè , Acosta Sandra , Edo Albert , Lloret María , Moret Roser , Bosch Elena , Oliva Baldo , Bertranpetit Jaume , Fernández-Fernández José Manuel 
Published: December 2020

AbstractTRPP3 (also called PKD2L1) is a nonselective, cation-permeable channel activated by multiple stimuli, including extracellular pH changes. TRPP3 had been considered a candidate for sour sensor in humans, due to its high expression in a subset of tongue receptor cells detecting sour, along with its membership to the TRP channel family known to function as sensory receptors. Here, we describe the functional consequences of two non-synonymous genetic variants (R278Q and R378W) found to be under strong positive selection in an Ethiopian population, the Gumuz. Electrophysiological studies and 3D modelling reveal TRPP3 loss-of-functions produced by both substitutions. R278Q impairs TRPP3 activation after alkalinisation by mislocation of H+ binding residues at the extracellular polycystin mucolipin domain. R378W dramatically reduces channel activity by altering conformation of the voltage sensor domain and hampering channel transition from closed to open state. Sour sensitivity tests in R278Q/R378W carriers argue against both any involvement of TRPP3 in sour detection and the role of such physiological process in the reported evolutionary positive selection past event.
ACE2 in the renin–angiotensin system
Authors: Verano-Braga Thiago , Martins Ana Luiza Valle , Motta-Santos Daisy , Campagnole-Santos Maria José , Santos Robson Augusto Souza 
Published: December 2020

AbstractIn 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin–angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic.
Controllable preparation and tunable magnetic anisotropy of amorphous LaxM1−xOy (M=Mn, Fe) nanowire arrays
Authors: Wang Fang‐Kuo , Yuan Xiao‐You 
Published: December 2020

Two LaxMn1−xOy (LM1, LM2) and three LaxFe1−xOy (LF1, LF2, LF3) amorphous nanowire arrays (NWAs) were prepared by chemical co‐precipitation in anodic aluminium oxide (AAO) templates. The concentration of the reactant plays a crucial role in determining the morphology of LaxMn1−xOy NWAs. The AAO template was etched using a mixed nitrate solution that led to the exposure of LaxFe1−xOy NWAs on the template surface in the process of preparation, then the length of nanowires exposed to the template depends on the etching time. The LM2 NWAs exhibited obvious magnetic anisotropy after the template is almost eliminated by etching with NaOH solution, while the magnetic anisotropy of LaxFe1−xOy NWAs was manipulated by the length of nanowires outside the template. There is a regular change in the coercive force Hc and remanence ratio Mr/Ms with increasing length of nanowires outside the template. Therefore, the nanoarray materials with tunable magnetic anisotropy were obtained by controllable preparation, and they can be applied to high‐density magnetic memory nano‐devices.
ReinvestigatingαCentauri AB in light of asteroseismic forward and inverse methods
Authors: Salmon S. J. A. J. , Van Grootel V. , Buldgen G. , Dupret M.-A. , Eggenberger P. 
Published: December 2020

Context.TheαCen stellar system is the closest neighbour to our Sun. Its main component is a binary composed of two main-sequence stars, one more massive than the Sun and one less massive. The system’s bright magnitude led to a wealth of astronomical observations over a long period, making it an appealing testbed for stellar physics. In particular, detection of stellar pulsations in bothαCen A and B has revealed the potential of asteroseismology for determining its fundamental stellar parameters. Asteroseismic studies have also focused on the presence of a convective core in the A component, but as yet without definitive confirmation.Aims.Progress in the determination of solar surface abundances and stellar opacities have yielded new input for stellar theoretical models. We investigate their impact on a reference system such asαCen AB. We seek to confirm the presence of a convective core inαCen A by analysing the role of different stellar physics and the potential of asteroseismic inverse methods.Methods.First, we present a new series of asteroseismic calibrations of the binary carried out using forward approach modelling and including updated chemical mixture and opacities in the models. We took advantage of the most up-to-date orbital solution as non-seismic constraints. We then complement our analysis with help of recent asteroseismic diagnostic tools based on inverse methods developed for solar-like stars.Results.The inclusion of an updated chemical mixture -that is less metal-rich- appears to reduce the predicted asteroseismic masses of each component. Neither classical asteroseismic indicators such as the frequency ratios, nor asteroseismic inversions favour the presence of a convective core inαCen A. The quality of the observational seismic dataset is the main limiting factor to settle the issue. Implementing new observing strategies to improve the precision on the pulsation frequencies would certainly refine the outcome of asteroseismology for this binary system.
Linking planetary embryo formation to planetesimal formation
Authors: Voelkel Oliver , Deienno Rogerio , Kretke Katherine , Klahr Hubert 
Published: December 2020

Context. The growth-timescales of planetary embryos and their formation process are imperative for our understanding on how planetary systems form and develop. They determine the subsequent growth mechanisms during the life stages of a circumstellar disk.
Aims. We quantify the timescales and spatial distribution of planetary embryos through collisional growth and fragmentation of dynamically forming 100 km sized planetesimals. In our study, the formation timescales of viscous disk evolution and planetesimal formation are linked to the formation of planetary embryos in the terrestrial planet zone.
Methods. We connected a one-dimensional model for viscous gas evolution, dust and pebble dynamics, and pebble flux-regulated planetesimal formation to the N-body code LIPAD. Our framework enabled us to study the formation, growth, fragmentation, and evolution of planetesimals with an initial size of 100 km in diameter for the first million years of a viscous disk.
Results. Our study shows the effect of the planetesimal surface density evolution on the preferential location and timescales of planetary embryo formation. Only the innermost embryos (<2 au) in our study form well within the lifetime of an active pebble flux for any disk studied. Higher planetesimal disk masses and steeper planetesimal surface density profiles result in more massive embryos within a larger area, rather than in a higher number of embryos. A one-dimensional analytically derived model for embryo formation based on the local planetesimal surface density evolution is presented. This model can reproduce the spatial distribution, formation rate, and total number of planetary embryos at a fraction of the computational cost of the N-body simulations.
Conclusions. The formation of planetary embryos in the terrestrial planet zone occurs simultaneously with the formation of planetesimals. The local planetesimal surface density evolution and the orbital spacing of planetary embryos in the oligarchic regime are good constraints for modeling planetary embryo formation analytically. Our embryo formation model is a valuable asset in future studies of planet formation.
Praktische Kieferorthopädie: Kasuistiken und
Workflows
Authors: Jung Britta A. 
Published: December 2020

Sehr geehrte Kolleginnen und Kollegen!Vor einiger Zeit ergab eine Umfrage des Thieme-Verlages, dass sich die Leserinnen und
Leser der IOK mehr Fallberichte wünschen. Daher haben wir in dieser Ausgabe
für Sie einige Kasuistiken zu verschiedenen Themenfeldern zusammengestellt.
Unter anderem werden dabei die Themen „digitale Kieferorthopädie,
Einstellmöglichkeiten von verlagerten Eckzähnen und
Doppelanlagen“ adressiert. Die Berichte stammen sowohl aus der Klink als
auch aus der Praxis und sollen Möglichkeiten zum diagnostischen und
therapeutischen Vorgehen aufzeigen.
Endoscopic management of enteral tubes in adult patients – Part 1: Definitions and indications. European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Arvanitakis Marianna , Gkolfakis Paraskevas , Despott Edward J. , Ballarin Asuncion , Beyna Torsten , Boeykens Kurt , Elbe Peter , Gisbertz Ingrid , Hoyois Alice , Mosteanu Ofelia , Sanders David S. , Schmidt Peter T. , Schneider Stéphane M. , van Hooft Jeanin E. 
Published: December 2020

Main recommendationsESGE recommends considering the following indications for enteral tube insertion: (i) clinical conditions that make oral intake impossible (neurological conditions, obstructive causes); (ii) acute and/or chronic diseases that result in a catabolic state where oral intake becomes insufficient; and (iii) chronic small-bowel obstruction requiring a decompression gastrostomy.Strong recommendation, low quality evidence.ESGE recommends the use of temporary feeding tubes placed through a natural orifice (either nostril) in patients expected to require enteral nutrition (EN) for less than 4 weeks. If it is anticipated that EN will be required for more than 4 weeks, percutaneous access should be considered, depending on the clinical setting.Strong recommendation, low quality evidence.ESGE recommends the gastric route as the primary option in patients in need of EN support. Only in patients with altered/unfavorable gastric anatomy (e. g. after previous surgery), impaired gastric emptying, intolerance to gastric feeding, or with a high risk of aspiration, should the jejunal route be chosen.Strong recommendation, moderate quality evidence.ESGE suggests that recent gastrointestinal (GI) bleeding due to peptic ulcer disease with risk of rebleeding should be considered to be a relative contraindication to percutaneous enteral access procedures, as should hemodynamic or respiratory instability.Weak recommendation, low quality evidence.ESGE suggests that the presence of ascites and ventriculoperitoneal shunts should be considered to be additional risk factors for infection and, therefore, further preventive precautions must be taken in these cases.Weak recommendation, low quality evidence.ESGE recommends that percutaneous tube placement (percutaneous endoscopic gastrostomy [PEG], percutaneous endoscopic gastrostomy with jejunal extension [PEG-J], or direct percutaneous endoscopic jejunostomy [D-PEJ]) should be considered to be a procedure with high hemorrhagic risk, and that in order to reduce this risk, specific guidelines for antiplatelet or anticoagulant use should be followed strictly.Strong recommendation, low quality evidence.ESGE recommends refraining from PEG placement in patients with advanced dementia.Strong recommendation, low quality evidence.ESGE recommends refraining from PEG placement in patients with a life expectancy shorter than 30 days.Strong recommendation, low quality evidence*.
Spontaneous Regression of a Giant Traumatic Herniated Thoracic Disk: A Case Report and Review of the Literature
Authors: Valluzzi Adelaide , Sorenson Thomas , Nasi Davide , Acciarri Nicola , Palandri Giorgio , Pavesi Giacomo 
Published: December 2020

AbstractThoracic disk herniation (TDH) after traumatic injury is a relatively uncommon disease with few cases reported in the literature. Herniated disks in this location typically may result in progressive myelopathy and refractory pain. In the presence of these symptoms, surgical treatment may be indicated since spontaneous regression in this area is less common than that of disk herniations in the cervical or lumbar spine. Herein, we present the case of giant traumatic TDH that occurred at the T9–T10 level and spontaneously resolved after 5 months.We highlight the fact that regression of a herniated disk at the thoracic level may occur even in the absence of treatment. When considering this phenomenon, conservative management of these cases with clinical and radiological monitoring may be an appropriate first-line management for patients without signs of progressive myelopathy or severe refractory pain.
Neuroanesthesia Practice during COVID-19: A Single-Center Experience
Authors: Gandhe Rajashree U. , Bhave Chinmaya P. , Gedam Neha T. , Sengupta Rashnita 
Published: December 2020

AbstractThe coronavirus disease 2019 (COVID-19) pandemic is a challenge for all health care providers (HCPs). Anesthesiologists are vulnerable to acquiring the disease during aerosol-generating procedures in operating theater and intensive care units. High index of suspicion, detailed history including travel history, strict hand hygiene, use of face masks, and appropriate personal protective equipment are some ways to minimize the risk of exposure to disease. Neurologic manifestations of COVID-19, modification of anesthesia regimen based on the procedure performed, and HCP safety are some implications relevant to a neuroanesthesiologist. National and international guidelines, recommendations, and position statements help in risk stratification, prioritization, and scheduling of neurosurgery and neurointervention procedures. Institutional protocols can be formulated based on the guidelines wherein each HCP has a definite role in this ever-changing scenario. Mental and physical well-being of HCPs is an integral part of successful management of patients. We present our experience in managing 143 patients during the lockdown period in India.
Analysis of the dynamics of a switched circuit from the bifurcation theory
Authors: González J R , Rivas E , Correa G 
Published: December 2020

Abstract
This document shows an analysis of the stability of a Buck type power converter, which, being a switched electronic circuit, has complex dynamics. The analysis consists of determining the influence on its stability of the variations of each of its parameters and determining the points where these changes occur, known as the bifurcation point. This analysis allows investigating these types of problems from the bifurcation theory allowing to understand the stability and operation of the converters.
Bang-Bang control over a direct current to direct current converter
Authors: Mesa F , Devia D M , Ospina R 
Published: December 2020

Abstract
The following document presents an optimal control technique to control power converters direct current to direct current using the Bang-Bang control technique, for example a Buck power reducing converter will be shown, Subsequently and using an approach based on the principle of the maximum of Pontryagin, an optimized switched control technique (bang-bang) is designed and implemented that allows to obtain a performance comparable to the on-off action in terms of dynamic characteristics. Additional tests allow quantifying the optimality of the proposed technique and verifying the performance of the controlled system in energy terms, showing that an optimal switched control has, in addition to the minimization of the functional cost (minimum error energy), a lower incidence in the generation of high frequency switching noise, compared to conventional technique. As one of the most important aspects highlighted in the results corresponds to the simplicity of design and the high efficiency of the Bang-Bang controllers, making the output voltage practically no ripples.
Impulsive simulation model for the analysis of allergy dynamics
Authors: Vergaño-Salazar J G , Pastenes L , Córdova-Lepe F , Mardones-Precht P 
Published: December 2020

Abstract
This work approach the analysis of the problems caused by the incidence of allergic diseases, using an impulsive simulation model as a methodological approach, in this, the dynamics of the model is governed by two time scales, one discrete and the other continuous which represents the interaction dynamics among pollen allergens, immune system and intestinal microbiota, evidencing the variable regulation of the Thymus by sending mature T lymphocytes into the bloodstream as a pulse. Due to the complexity of the interacting systems, scientific computing is used to represents a model at the microscopic level where the particles obey a simplified dynamic. To carry out the simulations, the values of parameters used are taken from secondary sources. The scenarios described in the simulations show the behavior of helper T cells, these being an indicator of allergic reactions. The model shows that the intestinal microbiota helps Treg cells in the inhibition of the immune response, also showing that if there is a high concentration of bacteria produced by the ingestion of functional foods, it is possible to control the allergic symptoms.
Parallel methods for linear systems solution in extreme learning machines: an overview
Authors: Gelvez-Almeida E , Baldera-Moreno Y , Huérfano Y , Vera M , Mora M , Barrientos R 
Published: December 2020

Abstract
This paper aims to present an updated review of parallel algorithms for solving square and rectangular single and double precision matrix linear systems using multi-core central processing units and graphic processing units. A brief description of the methods for the solution of linear systems based on operations, factorization and iterations was made. The methodology implemented, in this article, is a documentary and it was based on the review of about 17 papers reported in the literature during the last five years (2016-2020). The disclosed findings demonstrate the potential of parallelism to significantly decrease extreme learning machines training times for problems with large amounts of data given the calculation of the Moore Penrose pseudo inverse. The implementation of parallel algorithms in the calculation of the pseudo-inverse will allow to contribute significantly in the applications of diversifying areas, since it can accelerate the training time of the extreme learning machines with optimal results.
Low-cost computational systems applied to physical architectures in public transportation systems of intermediate cities
Authors: Ramirez-Guerrero T , Toro M , Villegas López G A , Castañeda L F 
Published: December 2020

Abstract
Public transportation systems in many cities of Latin America must employ physical architectures of intelligent transportation systems for the operation and control of passenger transportation vehicles. However, the high cost of specialized computational systems for this physical architectures in one of the higher impediments to the integration of this systems in the vehicle network. For the purpose of this work, is necessary to ask what are the currently low-cost computational systems used in vehicular applications. In this paper we made a documentary research to analyse the current computational systems associated with the physical architecture for public transportation in intermediate cities. We analysed collected information following the three points of methodological development for a documentary researches. Results shows that the use of low-cost computational systems for data capture in vehicles, the use of millimetre waves in the electromagnetic spectrum for data transmission by means of mobile communication networks, and the adoption of international standards, are viable alternatives for the integration of technologies into physical architectures of vehicle networks, in order to improve the operation of public passenger transportation systems in intermediate cities in Latin America.
Mathematics teacher’ perceptions and adaptations in developing online classes - ideas for teacher training
Authors: Guerrero-Ortiz C , Huincahue J 
Published: December 2020

AbstractThe wide availability of digital tools, as well as the current global pandemic has transformed the way in which teachers and students interact. This of course will have consequences on the learning of in physics and mathematics in the medium and long term. The objective of this research is to explore what are the feelings, difficulties and adaptations of the teachers to develop online classes. We reach this goal with support on the tetrahedron model for a didactical situation, which describes the interactions between student, teacher, content, and technology. Following a qualitative methodology, a survey of 48 in-service teachers was conducted to explore how teachers’ knowledge and their use of digital tools influence teacher-student-technology interactions. The results showed that 65% of the participants feel prepared for online teaching, while 35% feel. However, there is not a big difference in the interactions they promote with the students. Teachers experiment a high level of negative emotions such as frustration and anxiety, many of these emotions were recognised in teachers feeling online teaching. The findings explain how emotional and infrastructural factors are related to the interactions in online teaching. The results have implications in physics and mathematics teacher training programs, the ways we teach physical and mathematical content, insofar we highlight those aspects into account to improve the students’ learning.