bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study
Authors: Ramezani Tehrani Fahimeh , Bidhendi Yarandi Razieh , Solaymani-Dodaran Masoud , Tohidi Maryam , Firouzi Faezeh , Azizi Fereidoun 
Published: February 2020

AbstractContextSeveral statistical models were introduced for the prediction of age at menopause using a single measurement of anti-müllerian hormone (AMH); however, individual prediction is challenging and needs to be improved.ObjectiveThe objective of this study was to determine whether multiple AMH measurements can improve the prediction of age at menopause.DesignAll eligible reproductive-age women (n = 959) were selected from the Tehran Lipid and Glucose Study. The serum concentration of AMH was measured at the time of recruitment and twice after that at an average of 6-year intervals. An accelerated failure-time model with Weibull distribution was used to predict age at menopause, using a single AMH value vs a model that included the annual AMH decline rate. The adequacy of these models was assessed using C statistics.ResultsThe median follow-up period was 14 years, and 529 women reached menopause. Adding the annual decline rate to the model that included single AMH improved the model’s discrimination adequacy from 70% (95% CI: 67% to 71%) to 78% (95% CI: 75% to 80%) in terms of C statistics. The median of differences between actual and predicted age at menopause for the first model was –0.48 years and decreased to –0.21 in the model that included the decline rate. The predicted age at menopause for women with the same amount of age-specific AMH but an annual AMH decline rate of 95 percentiles was about one decade lower than in those with a decline rate of 5 percentiles.ConclusionPrediction of age at menopause could be improved by multiple AMH measurements; it will be useful in identifying women at risk of early menopause.
<p><strong>First country record of </strong><strong><em>Pseudoathyreus orientalis </em></strong><strong>(Coleoptera: Bolboceratidae: </strong><strong>Athyreinae) from Pakistan</strong></p>
Authors: SOMMER DAVID , HRŮZOVÁ LUCIE , KRÁL DAVID 
Published: February 2020

Bolboceratidae is a large family of about 600 species (e.g., Schoolmeesters 2019), in the superfamily Scarabaeoidea. Currently, it includes two subfamilies, Athyreinae and Bolboceratinae (e.g., Scholtz & Grebennikov 2016; Nikolajev et al. 2016). The Athyreinae includes five genera and about 130 species from the Afrotropical, Neotropical, Oriental and Palearctic regions (e.g., Schoolmeesters 2019). The genus Pseudoathyreus Howden & Martínez, 1963 contains nine species occurring in Africa and Asia (e.g., Carpaneto et al. 2000; Schoolmeesters 2019). Little is known about the biology of Athyreinae (Scholtz & Grebennikov 2016). Immature stages of this group remain unknown (Grebennikov & Scholtz 2004).
John Rawls' Theory of Justice Applied to Sustainable Development
Authors: Farias Athena de Albuquerque 
Published: February 2020

Sustainable development is a systemic concept, which aims at global development together with the concern with the preservation of nature. This study aims to apply the Rawlsian Theory into sustainable development. Considerations seems to allow that, with the collaboration of society in an egalitarian and cooperative way, it is possible to mitigate or overcome existing environmental challenges. The present study it presents a new aspect capable of helping in the solution and management of environmental issues currently faced globally. Keywords: Sustainable development; John Rawls; Global challenges.
Diagnóstico de Câncer durante a Gestação: Uma Revisão Integrativa / Cancer Diagnosis During Pregnancy: An Integrative Review
Authors: Brito Eulina Alves Sousa , Feitosa Pedro Walisson Gomes , Vieira Jacyanne Gino , Oliveira Italo Constâncio de , Sousa Carmelita Maria Silva , Santana Willma José de 
Published: February 2020

Entre o aumento no número de casos de neoplasias, apresentam-se em destaque as ocorrências em mulheres em idade fértil, as quais denotam sérias consequências em seu futuro reprodutivo. Dentre estas pacientes em idade fértil com diagnóstico de câncer, existe uma pequena, porém relevante, parcela de mulheres que tiveram diagnóstico de câncer durante a gestação ou que, no decorrer do tratamento/seguimento de uma neoplasia, engravidaram. Assim, este trabalho objetiva realizar uma revisão integrativa da literatura dos últimos cinco anos quanto condutas relacionadas ao diagnóstico de câncer durante a gestação. Buscou-se artigos na Biblioteca Virtual de Saúde (BVS). Foram utilizados os descritores de saúde (DeCS): “Câncer”, Diagnóstico” e “Gestação”. Foram considerados critérios de inclusão artigos em português, inglês e espanhol, disponíveis na íntegra, publicados entre 2014 e 2019. A busca inicial com os descritores identificou 12. 377 artigos. Destes, após aplicação dos critérios de inclusão, 11 foram selecionados como amostra final. A síntese do conhecimento referenciado nesta revisão integrativa indica que, consoante a literatura analisada, há evidências que a gestação não acelera a evolução do câncer, estando o mau prognóstico relacionado ao estadiamento tardio do tumor. Ainda, os estudos reforçam a importância do diagnóstico precoce, o qual pode contribuir para a melhoria do prognóstico de mulheres com câncer na gravidez. Assim, frisa-se o papel de uma equipe multidisciplinar direcionada ao diagnóstico precoce.
Mortality Risk in Irritable Bowel Syndrome: Results From a Nationwide Prospective Cohort Study
Authors: Staller Kyle , Olén Ola , Söderling Jonas , Roelstraete Bjorn , Törnblom Hans , Khalili Hamed , Joshi Amit D. , Nguyen Long H. , Song Mingyang , Kuo Braden , Chan Andrew T. , Ludvigsson Jonas F. 
Published: February 2020

INTRODUCTION:
Mortality concern is a frequent driver of care seeking in patients with irritable bowel syndrome (IBS). Data on mortality in IBS are scarce, and population-based studies have been limited in size. We examined mortality in IBS.

METHODS:
A nationwide, matched, population-based cohort study was conducted in Sweden. We identified 45,524 patients undergoing a colorectal biopsy at any of Sweden's 28 pathology departments and with a diagnosis of IBS from 2002 to 2016 according to the National Patient Register, a nationwide registry of inpatient and outpatient specialty care. We compared the mortality risk between these individuals with IBS and age- and sex-matched reference individuals (n = 217,316) from the general population and siblings (n = 53,228). In separate analyses, we examined the role of mucosal appearance for mortality in IBS. Finally, we examined mortality in 41,427 patients with IBS not undergoing a colorectal biopsy. Cox regression estimated hazard ratios (HRs) for death.

RESULTS:
During follow-up, there were 3,290 deaths in individuals with IBS (9.4/1,000 person-years) compared with 13,255 deaths in reference individuals (7.9/1,000 person-years), resulting in an HR of 1.10 (95% confidence interval [CI] = 1.05–1.14). After adjustment for confounders, IBS was not linked to mortality (HR = 0.96; 95% CI = 0.92–1.00). The risk estimates were neutral when patients with IBS were compared with their siblings. The underlying mucosal appearance on biopsy had only a marginal impact on mortality, and patients with IBS not undergoing a colorectal biopsy were at no increased risk of death (HR = 1.02; 95% CI = 0.99–1.06).

DISCUSSION:
IBS does not seem to confer an increased risk of death.
As concepções sobre analogias no discurso de licenciandos em ciências biológicas
Authors: Almeida Hederson Aparecido de 
Published: February 2020

As analogias no ensino de Ciências são comparações entre dois domínios heterogêneos, um familiar e outro não familiar. Apesar de serem usadas frequentemente em sala de aula, tanto por professores quanto por alunos, é recorrente as confusões em relação ao seu significado, porque são enunciadas sem nenhum planejamento prévio. Essa constatação pode ser explicada pelo fato dos cursos de licenciatura não possuírem disciplinas que comtemplem tais discussões. Formam-se, assim, professores que utilizarão desses recursos em sala de aula, mas que não refletirão sobre a temática. Neste sentido, o presente estudo teve por objetivo identificar quais são as concepções que alunos de dois cursos de Ciências Biológicas possuem sobre o uso das analogias no ensino. A pesquisa caracterizou-se como qualitativa, sendo os dados obtidos mediante a aplicação de um questionário semiestruturado com quatro questões. Estas mapearam a concepção dos licenciandos sobre o uso das analogias para fazerem explicações, em que momentos, e se as analogias e metáforas possuem o mesmo significado. Os resultados mostram que a concepção dos estudantes sobre o tema é diversa. Há uma íntima associação entre os órgãos análogos da biologia evolutiva com as analogias enquanto recurso didático, mostrando uma confusão entre a analogia didática e a analogia biológica. Ao tentar diferenciá-las, os discentes confundem-nas com outras tipologias de comparações, como as metáforas; utilizam do recurso para facilitar a compreensão do assunto trabalhado; quando o conceito é considerado abstrato ou difícil; para introduzir um novo assunto ou para explicar novamente um conteúdo. É necessário que as discussões em torno da temática se iniciem ainda na formação inicial para que o uso espontâneo das analogias seja superado por processos reflexivos.
Use of phosphatase and dehydrogenase activities in the assessment of calcium peroxide and citric acid effects in soil contaminated with petrol
Authors: Curyło Kornel , Telesiński Arkadiusz 
Published: February 2020

AbstractThe objective of the study was to compare the effect of calcium peroxide and citric acid on the activity of acid phosphatase (ACP), alkaline phosphatase (ALP), and dehydrogenases (DHA) in uncontaminated soil and soil contaminated with petrol. The experiment was carried out on samples of loamy sand under laboratory conditions. Petrol was introduced to soil samples at a dose of 0 and 50 g·kg 1 DM, as well as calcium peroxide or citric acid at a dose of 0, 50, 100, or 150 mg·kg 1 DM. The humidity of the samples was brought to 60% maximum water holding capacity, and the samples were incubated at 20°C for 8 weeks. Enzyme activity was determined on days 1, 14, 28, and 56. The obtained results demonstrated that the addition of calcium peroxide and citric acid did not result in significant changes in the activity of the determined enzymes in uncontaminated soil. However, it was observed that the application of calcium peroxide, particularly at the dose of 150 mg·kg 1 DM, largely alleviated the impact of petrol on the enzymatic activity of the soil contaminated with petrol. Moreover, among the determined enzymes, the activity of DHA was found to be the best indicator of the effect of calcium peroxide on the soil ecosystem.
Morphine modulates hippocampal neurogenesis and contextual memory extinction via miR-34c/Notch1 pathway in male ICR mice
Authors: Hu JieWei , Cui FuHua , Zhang XiaoDong 
Published: February 2020

AbstractBackgroundThe opioid Morphine is known to affect neurogenesis in the hippocampus. Evidence has shown that several microRNAs modulate morphine-induced neurogenesis, and hence morphine-induced contextual memory. This complex network has yet to be elucidated. In this study, we screened for morphine addiction related microRNA and determined its effects on hippocampal neurogenesis and morphine-induced contextual memory using the conditioned place preference (CPP) model.MethodsThe previously established CPP model was utilized in this study. For differential expression of miRNA in the hippocampus, the GeneChip miRNA array was used. Lentivirus technology was used to overexpress or downregulate the miRNA, and changes in expression level was verified with qRT-PCR. Protein expression levels were measured with western blot. Immunofluorescence was used to observe the protein expression during the differentiation of NSCs.ResultsThe results showed that morphine administration upregulated microRNA-34c (miR-34c) and Notch1. Downregulating miR-34c in vivo decreased Notch1 expression and partially rescued the morphine-induced inhibition of the differentiation of neural stem cells (NSCs). This did not affect the morphine-induced proliferation of cells. Furthermore, downregulating miR-34c in vivo prolonged the extinction of morphine-induced contextual memory without affecting acquired CPP response.ConclusionThe miR-34c regulates the hippocampal neurogenesis in addicted mice by up-regulating Notch1 expression, by inhibiting differentiation of neural precursor cells. The miR-34c/Notch1 pathway may be a new potential target for the prevention and treatment of opioid psychotic dependence.
Does Entrepreneurship Matter for Inclusive Growth? The Role of Social Progress Orientation
Authors: Aparicio Sebastian , Audretsch David , Urbano David 
Published: February 2020

AbstractBuilding upon institutional economics, we examine how social progress orientation (SPO) affects inclusive growth through innovative and opportunity entrepreneurship. Hypotheses about civic activism, voluntary spirit, and the inclusion of minorities as proxies of SPO that affect entrepreneurship directly and inclusive growth indirectly have been suggested. Using unbalanced panel data of 132 observations (63 countries) and the three-stage least-squares method (3SLS), we provide empirical evidence that these three measures of SPO significantly affect innovative and opportunity entrepreneurship. Interestingly, our endogenous measures of entrepreneurial activity have served to explain inclusive growth, which is observed through poverty reduction across countries. Public policies should focus on social values oriented to progress in order to stimulate valuable entrepreneurial activity and hence facilitate economic development that also embraces vulnerable communities.
Effects of lignin structure and solvent on the formation rate of quinone methide under alkaline conditions
Authors: Yamauchi Fuyu , Ito Toko , Kawamoto Osamu , Komatsu Toshihiro , Akiyama Takuya , Yokoyama Tomoya , Matsumoto Yuji 
Published: February 2020

Abstract
The purpose of this study was to examine how differences in the type of aromatic nucleus, side-chain structure and type of solvent affect the formation rate of quinone methide (QM) in the alkaline reaction of lignin. The reaction was done at a NaOH concentration of 1.0 mol l−1 and temperature of 75–140°C under an anaerobic condition. The formation rates of QM were in the order: syringyl > guaiacyl > p-hydroxyphenyl, when model compounds with lignin-type aromatic nuclei were compared. This and other results on various phenolic compounds suggested that the formation of QM is rapid from compounds having a high electron density in the aromatic π-electron system. The formation of QM was faster from a C6-C2-type than from a C6-C1-type lignin model compound, which was attributed to the fact that QM is an alkene and hence more stable when an unsaturated carbon in QM has an alkyl substituent, like the C6-C2-type compound. When aqueous 1,4-dioxane solutions with different 1,4-dioxane contents were used, the formation of QM became slower with increasing 1,4-dioxane content. This can be explained by the variation in the negative charge density in the rate-determining step, where the density is larger at the transition than at the initial state and consequently the activation energy is lower in a solvent with higher polarity.
Knowledge and attitudes about toxoplasmosis among female university students in Egypt
Authors: Senosy Shaimaa A. 
Published: February 2020

Abstract

Aim
This study aimed to assess toxoplasmosis-related knowledge, attitudes and preventive practices among female undergraduate students in Beni-Suef University, Egypt.

Subjects and methods
A cross-sectional design with a multi-stage random sample of female Beni-Suef university students were recruited in this survey over a period of 8 weeks’ duration using a self-administrated questionnaire.

Results
Among 1079 female students, only 35 (3.2%) had good knowledge. Female students of the Health Care faculty and students from rural areas had a significantly higher rate of good knowledge. The results also illustrated that most of the studied sample (63%) had a negative attitude. Nearly one-third of participants were convinced that toxoplasmosis shows symptoms and only (25.6%) agreed about the occurrence of toxoplasmosis infection during pregnancy. A significant positive correlation was found between the total knowledge score and the total attitude score of female students, indicating that students with better knowledge had more positive attitudes. Of the participants, 67.1% always ate fast food, while 70.7%, 72% and 78.2% of female students reported hand washing after gardening, cleaning areas where cats were and cooking with meat, respectively.

Conclusion
Knowledge regarding toxoplasmosis was deficient among female students attending Beni-Suef University, and they had a negative attitude regarding toxoplasmosis. There was also a positive correlation between students’ knowledge and their attitude toward toxoplasmosis infection. Many students avoided risk behaviors in the correct way, without realizing what they avoided. There is a critical need for efficient educational programs to raise the population’s awareness regarding toxoplasmosis.
Modified SRK Equation of State for Modeling Asphaltene Precipitation
Authors: Hajizadeh Neda , Moradi Gholamreza , Ashoori Siavash 
Published: February 2020

AbstractMany of oil reservoirs have dealt with operational problems due to probability of asphaltene deposition as a consequence of asphaltene precipitation during natural production and gas injection into the reservoir. So the prediction of asphaltene precipitation is very important and many equations of state (such as Ping Robinson (PR) and Soave–Redlich–Kwong (SRK)) are used for this reason. These common equations are suitable for non-polar components and a modification is necessary to use them for prediction of asphaltene precipitation because of the polar nature of asphaltene compounds. In this study, the SRK equation of state was modified by deriving a new equation for calculating b-parameter (co-volume parameter); and this modified SRK equation of state was used to model asphaltene precipitation. Finally asphaltene precipitation during natural depletion and first stage gas injection process (in different concentrations), was monitored at reservoir temperature and various pressures. The experimental results show a good match with the modified SRK equation of state.
Evaluation of the Hardness of Pumpkin Pulp Depending on the Implemented Heat Treatment
Authors: Marian Panasiewicz , Jacek Mazur , Paweł Sobczak , Kazimierz Zawiślak , Grzegorz Łysiak 
Published: February 2020

Abstract
The work is a compilation of the research results concerning the evaluation of the hardness of pumpkin pulp depending on the implemented methods of heat treatment, i. e. scalding pumpkin in hot water and acting on it with water steam. Extended time of pumpkin heat treatment, both in hot water and combi steamer with steam during 6 min resulted in the reduction of the pulp hardness at 46 % after steaming and 88 % after boiling and softening of the skin, which eased its mechanical removal (cleavage) from the pumpkin fruit. The study was targeted to search for the methods allowing the facilitation and mechanisation of skin removal process in the course of acquiring pumpkin pulp for food purposes.
(Since When) Are East and West German Business Cycles Synchronised?
Authors: Gießler Stefan , Heinisch Katja , Holtemöller Oliver 
Published: February 2020

Abstract
We analyze whether, and since when, East and West German business cycles are synchronised. We investigate real GDP, unemployment rates and survey data as business cycle indicators and we employ several empirical methods. Overall, we find that the regional business cycles have synchronised over time. GDP-based indicators and survey data show a higher degree of synchronisation than the indicators based on unemployment rates. However, synchronisation among East and West German business cycles seems to have become weaker again recently.
Variant analysis of HPD genes from two families showing elevated tyrosine upon newborn screening by tandem mass spectrometry (MS/MS)
Authors: Zhao Dehua , Tian Yuan , Li Xiaole , Ni Min , Zhu Xinyun , Jia Liting 
Published: February 2020

AbstractBackgroundAlterations in the structure and activity of 4-hydroxyphenylpyruvate dioxygenase (HPD) are causally related to two different metabolic disorders: recessively inherited tyrosinemia type III and dominantly inherited hawkinsinuria. The aim of this study was to provide a new perspective for the clinical understanding of the pathogenesis of tyrosinemia type III or hawkinsinuria.Case presentationA full-term newborn baby born after a safe pregnancy and childbirth with a birth weight of 3200 g and another full-term baby born after a safe pregnancy and childbirth with a birth weight of 2800 g are reported and analysed. DNA extraction, next-generation sequencing, bioinformatics analysis, Sanger sequencing and biochemical analysis were performed. One patient with a heterozygousHPDgene (NM_002150.2) c.460G > A mutation and one patient with a heterozygousHPDgene (NM_002150.2) c.248delG mutation showing elevated tyrosine levels upon newborn screening by tandem mass spectrometry (MS/MS) are reported.ConclusionsTheHPDgene may not be a strictly autosomal recessive pathogenic gene, which provides a new perspective for the clinical understanding of the pathogenesis of tyrosinemia type III or hawkinsinuria.
Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls
Authors: Jacob Elena , Braun Janina , Oelmeier Kathrin , Köster Helen Ann , Möllers Mareike , Falkenberg Maria , Klockenbusch Walter , Schmitz Ralf , Hammer Kerstin 
Published: March 2020

AbstractObjectiveTo assess whether fetal brain structures routinely measured during the second and third trimester ultrasound scans, particularly the width of the cavum septi pellucidi (CSP), differ between fetuses small for gestational age (SGA), fetuses very small for gestational age (VSGA) and normal controls.MethodsIn this retrospective study, we examined standard ultrasound measurements of 116 VSGA, 131 SGA fetuses and 136 normal controls including the head circumference (HC), transversal diameter of the cerebellum (TCD), the sizes of the lateral ventricle (LV) and the cisterna magna (CM) from the second and third trimester ultrasound scans extracted from a clinical database. We measured the CSP in these archived ultrasound scans. The HC/CSP, HC/LV, HC/CM and HC/TCD ratios were calculated as relative values independent of the fetal size.ResultsThe HC/CSP ratio differed notably between the controls and each of the other groups (VSGA P = 0.018 and SGA P = 0.017). No notable difference in the HC/CSP ratio between the VSGA and SGA groups could be found (P = 0.960). The HC/LV, HC/CM and HC/TCD ratios were similar in all the three groups.ConclusionRelative to HC, the CSP is larger in VSGA and SGA fetuses than in normal controls. However, there is no notable difference between VSGA and SGA fetuses, which might be an indicator for abnormal brain development in this group.
The crystal structure of 2-(4-chloro-6-nitrophenyl)-1-(4-chloro-3-nitrophenyl)diazene 1-oxide, C12H6Cl2N4O5
Authors: Cai Cao , Jingqi Wang , Min Li , Jun Chen , Jianlong Wang 
Published: February 2020

Abstract
C12H6Cl2N4O5, monoclinic, P21/c (no. 14), a = 11.4268(16) Å, b = 5.1250(8) Å, c = 23.569(4) Å, β = 91.738(6)°, V = 1379.62(40) Å3, Z = 4, R
gt(F) = 0.0555, wR
ref(F
2) = 0.1632, T = 100 K.