bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic profiles of socio-economic position: a multi-cohort analysis
Authors: Robinson Oliver , Carter Alice R , Ala-Korpela Mika , Casas Juan P , Chaturvedi Nishi , Engmann Jorgen , Howe Laura D , Hughes Alun D , Järvelin Marjo-Riitta , Kähönen Mika , Karhunen Ville , Kuh Diana , Shah Tina , Ben-Shlomo Yoav , Sofat Reecha , Lau Chung-Ho E , Lehtimäki Terho , Menon Usha , Raitakari Olli , Ryan Andy , Providencia Rui , Smith Stephanie , Taylor Julie , Tillin Therese , Viikari Jorma , Wong Andrew , Hingorani Aroon D , Kivimäki Mika , Vineis Paolo 
Published: September 2020

Abstract

Background
Low socio-economic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear.

Methods
We examined SEP as a determinant of serum nuclear magnetic resonance metabolic profiles in ∼30 000 adults and 4000 children across 10 UK and Finnish cohort studies.

Results
In risk-factor-adjusted analysis of 233 metabolic measures, low educational attainment was associated with 37 measures including higher levels of triglycerides in small high-density lipoproteins (HDL) and lower levels of docosahexaenoic acid (DHA), omega-3 fatty acids, apolipoprotein A1, large and very large HDL particles (including levels of their respective lipid constituents) and cholesterol measures across different density lipoproteins. Among adults whose father worked in manual occupations, associations with apolipoprotein A1, large and very large HDL particles and HDL-2 cholesterol remained after adjustment for SEP in later life. Among manual workers, levels of glutamine were higher compared with non-manual workers. All three indicators of low SEP were associated with lower DHA, omega-3 fatty acids and HDL diameter. At all ages, children of manual workers had lower levels of DHA as a proportion of total fatty acids.

Conclusions
Our work indicates that social and economic factors have a measurable impact on human physiology. Lower SEP was independently associated with a generally unfavourable metabolic profile, consistent across ages and cohorts. The metabolites we found to be associated with SEP, including DHA, are known to predict cardiovascular disease and cognitive decline in later life and may contribute to health inequalities.
How states react to the international regime complexities on migration: a study of cases in South East Asia and beyond
Authors: Okabe Midori 
Published: September 2020

AbstractThis article provides a holistic analysis of the ‘migration regime complex’ in Asia, which is distinguished from other regions of the world in the absence of a refugee protection regime. The ‘refugee regime complexity’ argument (Betts) fails to take into consideration the deviant behaviors of Asian states that have been excluded from the core institution building. The immigration control policies of Asian countries reflect their respective strategies that seek to take advantage of the economic opportunities provided by the international environment within the domestic sociopolitical constraints. The case studies show that Asian states while rejecting the UN-led refugee regime, tolerate irregular migration not only to protect their vital interest in economic development but also to maintain political stability at both national and regional levels.
Renal medication-related clinical decision support (CDS) alerts and overrides in the inpatient setting following implementation of a commercial electronic health record: implications for designing more effective alerts
Authors: Shah Sonam N , Amato Mary G , Garlo Katherine G , Seger Diane L , Bates David W 
Published: September 2020

Abstract

Objective
To assess the appropriateness of medication-related clinical decision support (CDS) alerts associated with renal insufficiency and the potential/actual harm from overriding the alerts.

Materials and Methods
Override rate frequency was recorded for all inpatients who had a renal CDS alert trigger between 05/2017 and 04/2018. Two random samples of 300 for each of 2 types of medication-related CDS alerts associated with renal insufficiency—“dose change” and “avoid medication”—were evaluated by 2 independent reviewers using predetermined criteria for appropriateness of alert trigger, appropriateness of override, and patient harm.

Results
We identified 37 100 “dose change” and 5095 “avoid medication” alerts in the population evaluated, and 100% of each were overridden. Dose change triggers were classified as 12.5% appropriate and overrides of these alerts classified as 90.5% appropriate. Avoid medication triggers were classified as 29.6% appropriate and overrides 76.5% appropriate. We identified 5 adverse drug events, and, of these, 4 of the 5 were due to inappropriately overridden alerts.

Conclusion
Alerts were nearly always presented inappropriately and were all overridden during the 1-year period studied. Alert fatigue resulting from receiving too many poor-quality alerts may result in failure to recognize errors that could lead to patient harm. Although medication-related CDS alerts associated with renal insufficiency had previously been found to be the most clinically beneficial alerts in a legacy system, in this system they were ineffective. These findings underscore the need for improvements in alert design, implementation, and monitoring of alert performance to make alerts more patient-specific and clinically appropriate.
John Singer Sargent, collector of modern art: works by Antonio Mancini and other Italian painters
Authors: Amedei Michele 
Published: September 2020

Abstract
The aim of this essay is to shed light on John Singer Sargent, the greatest American Impressionist in Europe at the turn of the nineteenth to twentieth centuries, as a collector of modern art. With the exception of a group of works by Old Masters such as Tintoretto and Giovanni Domenico Tiepolo, the American artist’s collection was, in fact, principally composed of contemporary works of art, most of which were by Italian painters, with several of whom Sargent enjoyed more or less close relationships. Sargent’s collection, sold at Christie’s on 24–7 July 1925, contained works by artists such as Giovanni Boldini, Alberto Falchetti, Ambrogio Raffele, Domenico Morelli and, in particular, Antonio Mancini – the last said to have been called by Sargent ‘the greatest living painter’, so overwhelmed was he by his friend’s virtuosity with the paintbrush.
Disentangling Complex Inheritance Patterns of Plant Organellar Genomes: An Example From Carrot
Authors: Mandel Jennifer R , Ramsey Adam J , Holley Jacob M , Scott Victoria A , Mody Dviti , Abbot Patrick 
Published: September 2020

Abstract
Plant mitochondria and plastids display an array of inheritance patterns and varying levels of heteroplasmy, where individuals harbor more than 1 version of a mitochondrial or plastid genome. Organelle inheritance in plants has the potential to be quite complex and can vary with plant growth, development, and reproduction. Few studies have sought to investigate these complicated patterns of within-individual variation and inheritance using experimental crosses in plants. We carried out crosses in carrot, Daucus carota L. (Apiaceae), which has previously been shown to exhibit organellar heteroplasmy. We used mitochondrial and plastid markers to begin to disentangle the patterns of organellar inheritance and the fate of heteroplasmic variation, with special focus on cases where the mother displayed heteroplasmy. We also investigated heteroplasmy across the plant, assaying leaf samples at different development stages and ages. Mitochondrial and plastid paternal leakage was rare and offspring received remarkably similar heteroplasmic mixtures to their heteroplasmic mothers, indicating that heteroplasmy is maintained over the course of maternal inheritance. When offspring did differ from their mother, they were likely to exhibit a loss of the genetic variation that was present in their mother. Finally, we found that mitochondrial variation did not vary significantly over plant development, indicating that substantial vegetative sorting did not occur. Our study is one of the first to quantitatively investigate inheritance patterns and heteroplasmy in plants using controlled crosses, and we look forward to future studies making use of whole genome information to study the complex evolutionary dynamics of plant organellar genomes.
A Different Epidemiology of Enterovirus A and Enterovirus B Co-circulating in Korea, 2012–2019
Authors: Kang Hae Ji , Yoon Youngsil , Lee Young-Pyo , Kim Hye-Jin , Lee Deog-Yong , Lee June-Woo , Hyeon Ji-Yeon , Yoo Jung Sik , Lee Sangwon , Kang Chun , Choi Wooyoung , Han Myung-Guk 
Published: September 2020

Abstract

Background
Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012–2019 based on national surveillance.

Methods
We collected specimens from patients with suspected EV infections and analyzed the data using real-time reverse-transcription polymerase chain reaction and VP1 gene sequencing.

Results
Among the 18 261 specimens collected, EVs were detected in 6258 (34.3%) cases. Although the most common EV types changed annually, EV-A71, echovirus 30, coxsackievirus B5, coxsackievirus A6, and coxsackievirus A10 were commonly identified. Among the human EVs, the case numbers associated with the 2 major epidemic species (EV-A and EV-B) peaked in the summer. While EV-A species affected 1-year-old children and were associated with herpangina and hand, foot, and mouth disease, EV-B species were mostly associated with neurologic manifestations. The highest incidence of EV-B species was observed in infants aged &lt;12 months. Feces and respiratory specimens were the most predictive of EV infection. Specimens collected within 5 days of symptom onset allowed for timely virus detection.

Conclusions
EV-A and EV-B species co-circulating in Korea presented different epidemiologic trends in clinical presentation, affected subjects, and seasonality trends. This study could provide information for the characterization of EVs circulating in Korea to aid the development of EV antivirals and vaccines, as well as public health measures to control enteroviral diseases.
Impact on dose distribution and volume changes of a bioabsorbable polyglycolic acid spacer during chemo-proton therapy for a pediatric Ewing sarcoma
Authors: Kimura Mitsuhiro , Asai Kumiko , Iwata Hiromitsu , Ogino Hiroyuki , Ito Yasuhiko , Kamei Michi , Takagi Daisuke , Maeda Naoko , Shibamoto Yuta 
Published: September 2020

ABSTRACTThe clinical utility of a recently developed bioabsorbable polyglycolic acid (PGA) spacer has not yet been established in pediatric patients; therefore, we aimed to investigate its utility during chemo-proton therapy for pediatric cancer. Proton depth–dose curves were obtained in a water phantom with or without the spacer. Computed tomography (CT) scans were performed for the PGA spacer immersed in saline for 2 weeks to measure CT numbers and estimate the relative stopping power (RSP) for the proton beams. The spacer was placed in a patient with sacral Ewing sarcoma receiving 55.8 Gy [relative biological effectiveness (RBE)] in 31 fractions and was evaluated using CT scans performed every other week. In addition, the images were used to quantitatively evaluate changes in volume and RSP of the spacer and dose distributions in normal tissues. The spacer immersed in saline had a CT number of 91 ± 7 (mean ± standard deviation) Hounsfield units, and the corresponding RSP was predicted to be 1.07 ± 0.01. The measured RSP agreed with the predicted one. The volumes of the large bowel and rectum receiving ≥45 Gy(RBE) (V45Gy) were significantly reduced by placing the spacer; V45Gy without and with the spacer were 48.5 and 0.01%, respectively, for the rectum and 7.2 and 0%, respectively, for the large bowel. The volume of the spacer and RSP decreased at rates of 4.6 and 0.44% per week, respectively, whereas the target dose coverage was maintained until the end of treatment. The PGA spacer was considered effective for pediatric cancer patients undergoing chemo-proton therapy.
An Evaluation of Mixture Confirmatory Factor Analysis for Detecting Social Desirability Bias
Authors: Cernat Alexandru , Vandenplas Caroline 
Published: September 2020

Abstract
Collecting sensitive data using surveys is one of the most challenging tasks facing survey methodologists as people may choose to answer questions untruthfully to present themselves in a positive light. In 2014, Mneimneh et al. proposed mixed Rasch models to detect socially desirable answering behaviors. This approach combines item response theory models with latent class analysis to differentiate substantive and biased answering patterns. Their results identified two latent classes, one of which was consistent with socially desirable answering. Our aim is to expand their approach to detecting social desirability by using a mixture confirmatory factor analysis (CFA) in round 7 of the European Social Survey. First, we attempt to estimate social desirability in three constructs separately (RQ1): effect of immigration on the country, allowing people to come in the country and social connection, using a mixture CFA. We then extend the analysis by (RQ2) introducing constraints between the latent classes, (RQ3) combining different constructs in one model, and (RQ4) comparing results in Belgium and the United Kingdom. In contrast with the paper published by Mneimneh et al. in 2014, the models with two latent classes do not have the best model fit. In addition, validation with the presence of a third person, the respondent’s reluctance to give answers and personality traits are not systematically in line with our expectations. A small simulation shows that the method would work if the data would behave as we expect, with social desirability being the main factor influencing answering patterns. We conclude that a mixture CFA might not be able to identify social desirability in different survey contexts, especially in complex data as originating in cross-national social surveys.
Nitrate reductases and hemoglobins control nitrogen-fixing symbiosis by regulating nitric oxide accumulation
Authors: Berger Antoine , Boscari Alexandre , Puppo Alain , Brouquisse Renaud 
Published: September 2020

Abstract
The interaction between legumes and rhizobia leads to the establishment of a symbiotic relationship between plant and bacteria. This is characterized by the formation of a new organ, the nodule, which facilitates the fixation of atmospheric nitrogen (N2) by nitrogenase through the creation of a hypoxic environment. Nitric oxide (NO) accumulates at each stage of the symbiotic process. NO is involved in defense responses, nodule organogenesis and development, nitrogen fixation metabolism, and senescence induction. During symbiosis, either successively or simultaneously, NO regulates gene expression, modulates enzyme activities, and acts as a metabolic intermediate in energy regeneration processes via phytoglobin-NO respiration and the bacterial denitrification pathway. Due to the transition from normoxia to hypoxia during nodule formation, and the progressive presence of the bacterial partner in the growing nodules, NO production and degradation pathways change during the symbiotic process. This review analyzes the different source and degradation pathways of NO, and highlights the role of nitrate reductases and hemoproteins of both the plant and bacterial partners in the control of NO accumulation.
Mass-loss along the red giant branch in 46 globular clusters and their multiple populations
Authors: Tailo M , Milone A P , Lagioia E P , D’Antona F , Marino A F , Vesperini E , Caloi V , Ventura P , Dondoglio E , Cordoni G 
Published: September 2020

ABSTRACT
The location of Galactic globular clusters’ (GC) stars on the horizontal branch (HB) should mainly depend on GC metallicity, the ‘first parameter’, but it is actually the result of complex interactions between the red giant branch (RGB) mass-loss, the coexistence of multiple stellar populations with different helium content, and the presence of a ‘second parameter’ that produces dramatic differences in HB morphology of GCs of similar metallicity and ages (like the pair M3–M13). In this work, we combine the entire data set from the Hubble Space Telescope Treasury survey and stellar evolutionary models, to analyse the HBs of 46 GCs. For the first time in a large sample of GCs, we generate population synthesis models, where the helium abundances for the first and the ‘extreme’ second generations are constrained using independent measurements based on RGB stars. The main results are as follows: (1) The mass-loss of first-generation stars is tightly correlated to cluster metallicity. (2) The location of helium enriched stars on the HB is reproduced only by adopting a higher RGB mass-loss than for the first generation. The difference in mass-loss correlates with helium enhancement and cluster mass. (3) A model of ‘pre-main sequence disc early loss’, previously developed by the authors, explains such a mass-loss increase and is consistent with the findings of multiple-population formation models predicting that populations more enhanced in helium tend to form with higher stellar densities and concentrations. (4) Helium-enhancement and mass-loss both contribute to the second parameter.
Hydrodynamic simulations of AGN jets: the impact of Riemann solvers and spatial reconstruction schemes on jet evolution
Authors: Musoke G , Young A J , Birkinshaw M 
Published: September 2020

ABSTRACT
Numerical simulations play an essential role in helping us to understand the physical processes behind relativistic jets in active galactic nuclei. The large number of hydrodynamic codes available today enables a variety of different numerical algorithms to be utilized when conducting the simulations. Since many of the simulations presented in the literature use different combinations of algorithms it is important to quantify the differences in jet evolution that can arise due to the precise numerical schemes used. We conduct a series of simulations using the flash (magneto-)hydrodynamics code in which we vary the Riemann solver and spatial reconstruction schemes to determine their impact on the evolution and dynamics of the jets. For highly refined grids the variation in the simulation results introduced by the different combinations of spatial reconstruction scheme and Riemann solver is typically small. A high level of convergence is found for simulations using third-order spatial reconstruction with the Harten–Lax–Van-Leer with contact and Hybrid Riemann solvers.
Parker Solar Probe observations of suprathermal electron flux enhancements originating from Coronal Hole boundaries
Authors: Macneil Allan R , Owens Mathew J , Berčič Laura , Finley Adam J 
Published: September 2020

ABSTRACT
Reconnection between pairs of solar magnetic flux elements, one open and the other a closed loop, is theorized to be a crucial process for both maintaining the structure of the corona and producing the solar wind. This ‘interchange reconnection’ is expected to be particularly active at the open-closed boundaries of coronal holes (CHs). Previous analysis of solar wind data at 1 au indicated that peaks in the flux of suprathermal electrons at slow–fast stream interfaces may arise from magnetic connection to the CH boundary, rather than dynamic effects such as compression. Further, offsets between the peak and stream interface locations are suggested to be the result of interchange reconnection at the source. As a preliminary test of these suggestions, we analyse two solar wind streams observed during the first Parker Solar Probe (PSP) perihelion encounter, each associated with equatorial CH boundaries (one leading and one trailing with respect to rotation). Each stream features a peak in suprathermal electron flux, the locations and associated plasma properties of which are indicative of a solar origin, in agreement with previous suggestions from 1 au observations. Discrepancies between locations of the flux peaks and other features suggest that these peaks may too be shifted by source region interchange reconnection. Our interpretation of each event is compatible with a global pattern of open flux transport, although random footpoint motions or other explanations remain feasible. These exploratory results highlight future opportunities for statistical studies regarding interchange reconnection and flux transport at CH boundaries with modern near-Sun missions.
The frequency of extreme X-ray variability for radio-quiet quasars
Authors: Timlin John D , Brandt W N , Zhu S , Liu H , Luo B , Ni Q 
Published: September 2020

ABSTRACT
We analyse 1598 serendipitous  Chandra X-ray observations of 462 radio-quiet quasars to constrain the frequency of extreme amplitude X-ray variability that is intrinsic to the quasar corona and innermost accretion flow. The quasars in this investigation are all spectroscopically confirmed, optically bright (mi ≤ 20.2), and contain no identifiable broad absorption lines in their optical/ultraviolet spectra. This sample includes quasars spanning z ≈ 0.1–4 and probes X-ray variability on time-scales of up to ≈12 rest-frame years. Variability amplitudes are computed between every epoch of observation for each quasar and are analysed as a function of time-scale and luminosity. The tail-heavy distributions of variability amplitudes at all time-scales indicate that extreme X-ray variations are driven by an additional physical mechanism and not just typical random fluctuations of the coronal emission. Similarly, extreme X-ray variations of low-luminosity quasars seem to be driven by an additional physical mechanism, whereas high-luminosity quasars seem more consistent with random fluctuations. The amplitude at which an X-ray variability event can be considered extreme is quantified for different time-scales and luminosities. Extreme X-ray variations occur more frequently at long time-scales (Δt ≳ 300 d) than at shorter time-scales and in low-luminosity quasars compared to high-luminosity quasars over a similar time-scale. A binomial analysis indicates that extreme intrinsic X-ray variations are rare, with a maximum occurrence rate of $\lt 2.4{{\ \rm per\ cent}}$ of observations. Finally, we present X-ray variability and basic optical emission-line properties of three archival quasars that have been newly discovered to exhibit extreme X-ray variability.