bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evolution of depression in first‐episode psychosis: A naturalistic database study
Authors: Basu Sutapa , Verma Swapna , Abdin Edimansyah 
Published: March 2020

AbstractDepression is commonly seen in the course of schizophrenia and can occur during any of the phases of the psychotic illness. The present study examines the incidence of depression at baseline and de novo depression in first episode of nonaffective psychoses and the course of depression in the 12 months following first‐episode psychosis, any predictive significance of baseline depression with recurrence of depression in the subsequent phases of the psychotic illness. The study was conducted with a clinical sample of 460 patients under the care of a first‐episode psychosis programme, and data relating to duration of untreated psychosis, sociodemographic data, Positive and Negative Symptom Scale (PANSS), Global Assessment of Functioning (GAF), and Clinical Global Impression (CGI) were collected. Diagnosis was made by at least two psychiatrists using SCID‐1, and depression was measured by Patient Health Questionnaire (PHQ‐9). Statistical analysis was performed using SAS version 9. We performed multiple logistic regression analyses to identify the sociodemographic and clinical factors that were associated with depression. Statistical significance was set at p value less than 0.05. We found that baseline depression was present in 34.42% patients with a preponderance of females (p = 0.047) and in those with secondary education. A suicide attempt is a strong predictor for depression at baseline. There was lower incidence of depression in those diagnosed with brief psychotic disorder (p = 0.015) and those with lower PANSS positive scores (p = 0.017). De novo depression over 12 months was 9.44%. Depression at 1‐year follow‐up was significantly predicted by depression at baseline.
Retracted: Perceived corporate social responsibility and innovative work behavior: The role of employee volunteerism and authenticity
Authors: Afridi Sajjad A. , Afsar Bilal , Shahjehan Asad , Rehman Zia U. , Haider Maqsood , Ullah Mehboob 
Published: March 2020

AbstractDespite the clear importance of perceived corporate social responsibility for employee's innovative work behavior, how and when perceived corporate social responsibility fosters said behavior is not very well understood. Research at the individual level of corporate social responsibility has been growing rapidly. This study proposes that perceived corporate social responsibility has a substantial influence on employee's innovative work behavior and this relationship is mediated by authenticity and volunteerism. A questionnaire survey consisting of 317 valid responses from employees and 175 valid responses from their respective supervisors in the hotel industry in Pakistan validated the proposed model. The current study found that perceived corporate social responsibility is positively related with an employee's innovative work behavior. Moreover, authenticity and employee volunteerism mediated the link between perceived corporate social responsibility and innovative work behavior. The practical implications to enhance individual innovative work behavior are discussed.
Controls on large boulder mobility in an ‘auto‐naturalized’ constructed step‐pool river: San Clemente Reroute and Dam Removal Project, Carmel River, California, USA
Authors: Smith Douglas P. , Kortman Stefanie R. , Caudillo Andrew M. , Kwan‐Davis Ruby L. , Wandke John J. , Klein Joseph W. , Gennaro Michael C.S. , Bogdan Mikaela A. , Vannerus Peter A. 
Published: March 2020

AbstractA 1200 m‐long river segment of Carmel River (California) was constructed to bypass trapped reservoir sediment when San Clemente Dam was removed from the Carmel River in 2015. Hundreds of large boulders were used to construct 53 steps in an 800 m‐long reach of the project. Nearly all the boulders were scattered to new locations in high flows of 2017, and have been relatively stable since that time. We analysed the causes of incipient motion and distance travelled for 226 randomly selected large boulders (0.5–1.8 m) impacted by a flood event in winter of 2019. Channel width, water depth, and isolation from neighbouring boulders were the main variables controlling individual large boulder incipient motion during a 10‐year peak flow event in the ‘auto‐naturalized’ constructed step‐pool river in 2019. There is weak statistical evidence that a combination of shear stress and the presence of boulders located laterally downstream of the subject boulder controlled the distance the boulder moved. Frequentist statistics and Akaike information criterion model comparison determined that boulder size, boulder shape, boulder roundness, and local thalweg slope were not good predictors of large boulder incipient motion or distance transported. Average dimensionless critical shear value for the four largest mobilized boulders (1.5–1.6 m) was 0.014. We describe the geomorphic history of the site and use our results to discuss potential causes of unanticipated large boulder transport at the site that occurred in a <2‐year peak flow of winter 2016 soon after step construction. © 2020 John Wiley & Sons, Ltd.
The sources and seasonal fluxes of particulate organic carbon in the Yellow River
Authors: Qu Yuanxin , Jin Zhangdong , Wang Jin , Wang Yunqiang , Xiao Jun , Gou Long‐Fei , Zhang Fei , Liu Chun‐Yao , Gao Yongli , Suarez Marina B. , Xu Xiaomei 
Published: March 2020

AbstractThe Yellow River transports a large amount of sediment and particulate organic carbon (POC), which is thought to mainly derive from erosion of the Chinese Loess Plateau (CLP). However, the compositions, sources and erosional fluxes of POC in the Yellow River remain poorly constrained. Here we combined measurements of mineralogy, total organic carbon content (OCtotal), stable organic carbon isotopes (δ13Corg), radiocarbon (14C) activity of organic matter in bulk suspended sediments collected seasonally from the upper and middle Yellow River, to quantify the compositions and fluxes of the POC and to assess its sources (biospheric and petrogenic POC, i.e. POCbio and POCpetro, respectively). The results showed that the POC loading of sediments was controlled by mineralogy, grain size and specific surface area of loess particles. The Fmod of POC (0.71 to 0.31) can be explained by mixing of POCpetro with modern and aged POCbio. A binary mixing model based on the hyperbolic relationship of the Fmod and OCtotal revealed a wide range of ages of POCbio from 1300 to 11100 14C years.Relative to the upstream station, the annual POCbio and POCpetro fluxes in the Yellow River are more than doubled after it flows crossing the CLP within 35% drainage area gain, resulting in POCbio and POCpetro yields of the CLP at 3.50 ± 0.59 and 0.48 ± 0.49 tC/km2/yr, respectively. POC flux seasonal variation revealed that monsoon rainfall exerts a first‐order control on the export of both POCbio and POCpetro from the CLP to the Yellow River, resulting in more than 90% of the annual POC exported during the monsoon season. Around one third of annual POC erosional flux was transported during a storm event period, highlighting the important role of extreme events in POC export in this large river. © 2020 John Wiley & Sons, Ltd.
Germline epigenetic inheritance: Challenges and opportunities for linking human paternal experience with offspring biology and health
Authors: Ryan Calen P. , Kuzawa Christopher W. 
Published: March 2020

AbstractRecently, novel experimental approaches and molecular techniques have demonstrated that a male's experiences can be transmitted through his germline via epigenetic processes. These findings suggest that paternal exposures influence phenotypic variation in unexposed progeny–a proposal that runs counter to canonical ideas about inheritance developed during the 20th century. Nevertheless, support for paternal germline epigenetic inheritance (GEI) in nonhuman mammals continues to grow and the mechanisms underlying this phenomenon are becoming clearer. To what extent do similar processes operate in humans, and if so, what are their implications for understanding human phenotypic variation, health, and evolution? Here, we review evidence for GEI in human and nonhuman mammals and evaluate these findings in relation to historical conceptions of heredity. Drawing on epidemiological data, reproductive biology, and molecular embryology, we outline developments and opportunities for the study of GEI in human populations, emphasizing the challenges that researchers in this area still face.
Optimization of the autoclave preparation process for improving resistant starch content in rice grains
Authors: Zheng Yunzhan , Wei Zhencheng , Zhang Ruifen , Deng Yuanyuan , Tang Xiaojun , Zhang Yan , Liu Guang , Liu Lei , Wang Jiajia , Liao Na , Zhang Mingwei 
Published: March 2020

AbstractThe autoclave preparation process to increase the content of resistant starch (RS) in rice grains was optimized, and the results showed that the optimal preparation process was obtained with a water content of 41.63%, a pH of 5.95, an autoclave time of 60.96 min, and a refrigeration time of 17.11 hr. Under these conditions, the theoretical value of RS content in rice grains reached 17.57%. After autoclaving, the estimated glycemic index (EGI) in rice grains was reduced from 78.35 to 66.08 measured after cooking, suggesting that autoclaving was capable of increasing the RS content in rice grains and reducing its EGI value. These results may help spark new concepts and methods for the development of specialized foods for specific populations, such as people with diabetes.
Effects of Fuel Cell Operating Conditions on Proton Exchange Membrane Durability at Open‐Circuit Voltage
Authors: Zhao N. , Chu Y. , Xie Z. , Eggen K. , Girard F. , Shi Z. 
Published: March 2020

AbstractProton exchange membrane fuel cells (PEMFCs) continue to face cost and durability challenges which need to be addressed before their large scale commercialization. The PEM is an essential component of the fuel cell stack and its durability is thus a critical factor for the overall fuel cell reliability. Significant membrane degradation leads to the development of internal transfer leaks and cell short circuiting irreversibly affecting the fuel cell's functionality. In this study, perfluorosulfonic acid (PFSA) membranes were investigated for the effects of operating temperature and relative humidity on membrane durability using an open circuit voltage (OCV) accelerated stress test. The response surface methodology (RSM) was used to evaluate and optimize the effects of the operating temperature and humidity. As a result, the optimum fuel cell operational region was mapped and suggested as an alternative approach to maintain membrane durability without modifying membrane materials. The mapping could provide valuable guidelines for PEMFC designers and system engineers to optimize the operating conditions during idling to achieve a targeted membrane lifetime.
Utilization of microvascular couplers in salvage arterial anastomosis in head and neck free flap surgery: Case series and literature review
Authors: Li Michael M. , Tamaki Akina , Seim Nolan B. , Kang Stephen Y. , Ozer Enver , Agrawal Amit , Old Matthew O. 
Published: March 2020

AbstractBackgroundIn microvascular reconstruction of ablative oncologic defects, coupler devices have traditionally been used for venous anastomosis, whereas the arterial anastomosis is hand‐sewn. In the setting of repeated intraoperative arterial anastomotic thrombosis, a coupler device may be of use in reducing the risk of rethrombosis.MethodsTwo patients were seen with advanced stage head and neck cancer and underwent oncologic resection. During microvascular reconstruction, a clot at the arterial anastomosis was encountered in both cases.ResultsAfter starting therapeutic anticoagulation and attempting unsuccessful suture reanastomosis, coupler devices were used for arterial anastomosis, resulting in viable free‐tissue transfer.ConclusionsAlthough traditionally used for venous anastomosis, coupler devices may serve a purpose in the salvage setting when facing repeated intraoperative arterial thrombosis.
Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN‐trial
Authors: Adrian Gabriel , Gebre‐Medhin Maria , Kjellén Elisabeth , Wieslander Elinore , Zackrisson Björn , Nilsson Per 
Published: March 2020

AbstractBackgroundA large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.MethodsThree hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.ResultsTumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.ConclusionAF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.
Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin
Authors: Dorst Andrea , Gademann Karl 
Published: March 2020

AbstractFidaxomicin (1, lipiarmycin A3, clostomicin B1, tiacumicin B) constitutes a glycosylated 18‐membered macrolactone and is a natural product isolated from various soil bacteria. Since 2011, fidaxomicin is a marketed antibiotic for the treatment of intestine infections caused by C. difficile in the clinic. Its promising in vitro antibacterial properties against resistant S. aureus and M. tuberculosis continue to attract interest. This review article describes the early history of the antibiotic fidaxomicin and highlights recent advances in the field, such as the elucidation of its mode of action and biosynthesis, as well as known derivatives. Furthermore, different synthetic strategies towards the total synthesis of fidaxomicin are summarized.
Good prognosis for follicular lymphoma with estrogen receptor α‐positive follicular dendritic cells
Authors: Ohe Rintaro , Meng Hong‐Xue , Yamada Akane , Ye Aung Naing , Kabasawa Takanobu , Tamura Yuka , Utsunomiya Aya , Tamazawa Nobuyuki , Kawamura Ichiro , Kitaoka Takumi , Suzuki Kazushi , Yanagiya Ryo , Toubai Tomomi , Ishizawa Kenichi , Yamakawa Mitsunori 
Published: March 2020

AbstractFollicular lymphoma (FL) has a meshwork of follicular dendritic cells (FDCs). We previously demonstrated the presence of estrogen receptor alpha (ERα)+CD23+ FDCs in grades 1‐2 FL. The significance of FDCs as a prognostic factor in FL remains unknown. The current study aimed to compare clinicopathological features, including prognosis, between FL with and without ERα+ FDCs. This study evaluated the clinicopathological significance of ERα expression in 70 FL patients by immunostaining. The presence of ERα mRNA on FDCs from 5 FL patients was confirmed by CD21/ERα double staining (immunohistochemistry and in situ hybridization). We defined patients with frequent ERα expression as the ERαhigh group and those with infrequent ERα expression as the ERαlow group. Thirty‐two patients were assigned to the ERαhigh group (45.7%), and 38 patients were assigned to the ERαlow group (54.3%). Both overall survival (OS) and progression‐free survival (PFS) were significantly better in the ERαhigh group than in the ERαlow group (OS, log‐rank, P = .0465; PFS, log‐rank, P = .0336). Moreover, high ERα expression on FDCs was an independent prognostic factor for OS in both the univariate ([hazard ratio] HR, 0.163; P = .0260) and multivariate (HR, 0.050; P = .0188) analyses and for PFS in both the univariate (HR, 0.232; P = .0213) and multivariate (HR, 0.084; P = .0243) analyses. ERα mRNA expression was detected in CD21+ FDCs within the neoplastic follicles of FL patients. In conclusion, a neoplastic follicular microenvironment with ERα‐positive FDCs might affect the grade and presence of the follicular pattern of FL and improve patient prognosis.
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients
Authors: Hosry Jeff , Miranda Roberto N. , Samaniego Felipe , Angelidakis Georgios , Torres Harrys A. 
Published: March 2020

AbstractFollicular lymphoma (FL) is the most common subtype of indolent non‐Hodgkin lymphoma. It has been hypothesized that chronic hepatitis C virus (HCV) infection stimulates IGH‐BCL2 clone proliferation, leading to development of FL. Furthermore, regression of FL after antiviral treatment without chemotherapy has been reported in HCV‐infected patients. To clarify the relationship between HCV and FL, we compared the prevalence of IGH‐BCL2 translocation and other clinicopathologic characteristics between HCV‐infected and HCV‐uninfected FL patients and determined the impact of HCV eradication on the oncologic outcomes of HCV‐infected FL patients. The study included HCV‐infected patients (cases) with FL seen at our institution during 2004‐2018. Cases were matched with HCV‐uninfected FL patients (controls) according to year of lymphoma diagnosis, sex, and hepatitis B serology. We studied 19 cases and 57 controls. More cases than controls had splenic involvement of FL (26% vs 5%, P = 0.02), higher histologic grade (grade 3 in 56% vs 24%, P = 0.01), absent or weak CD10 expression (42% vs 11%, P = 0.005), and absent BCL2 expression (33% vs 4%, P = 0.004). Compared to controls, cases had a lower rate of detection of IGH‐BCL2 translocation (31% vs 68%, P = 0.02). Finally, cases with a sustained virologic response (virologic cure of HCV) had a better 10‐year overall survival rate than did cases not treated with antivirals or controls (P = 0.001). In conclusion, HCV‐infected patients with FL have unique clinicopathologic characteristics including improved overall survival with HCV eradication. The pathogenesis of FL in HCV‐infected patients seems unrelated to antiapoptotic effect of IGH‐BCL2 rearrangement.
Remediation of a Riparian Site in the Brazilian Atlantic Forest Reached by Contaminated Tailings from the Collapsed Fundão Dam with Native Woody Species
Authors: Scotti Maria Rita , Gomes Alessandra R , Lacerda Tomás J , Ávila Stefânia S , Silva Samuel LL , Antão Arthur , Santos Amanda GP , Medeiros Mirelli B , Alvarenga Stael , Santos Carlos Henrique , Rigobelo Everlon C 
Published: March 2020

Abstract
The failure of the Fundão dam in Brazil spilled alkaline contaminated sediments (pH ~8) into the Doce River basin. The contaminated sediments had high levels of ether amine (6 mg/kg) and Na (54 mg/kg) in relation to those in preserved sites. In the present study, a riparian forest was established over contaminated sediment using 2 main remediation strategies: phytoremediation with species native to the Atlantic forest and previously selected for their tolerance to sediment toxicity, and physicochemical remediation by incorporating organic matter (OM) into the sediment. In the experimental site (ES), the tolerant native woody species were cultivated in 2 treatments: T1, scraping of the sediments and incorporation of the OM, and T2, nonmanaged sediment and superficial deposition of the OM. The results were compared with the findings from a degraded site (DS), which was reached by the contaminated sediments but lacked vegetation, and a preserved site (PS), which was composed of a fragment of preserved Atlantic forest. Six months after transplanting, the plants from T1 showed a better height growth performance and survival index in relation to those from T2. Furthermore, T1 showed a significant decline in the pH (to ~6) concomitant with a reduction in the ether amine and Na contents (to ~0.4 mg/kg and 23 mg/kg, respectively). There was an improvement in the soil fertility and total microbial biomass in both treatments, especially in T1. Therefore, the adopted phyto- and physicochemical remediation procedures are recommended to reclaim zones reached by dam tailings containing Na and ether amine. Integr Environ Assess Manag 2020;16:669–675. © 2020 SETAC
An intelligent IoT with cloud centric medical decision support system for chronic kidney disease prediction
Authors: Arulanthu Pramila , Perumal Eswaran 
Published: March 2020

AbstractAt present days, Internet of Things (IoT) and cloud platforms become widely used in various healthcare applications. The enormous quantity of data produced by the IoT devices in the healthcare sector can be examined on the cloud platform instead of dependent on restricted storage and computation resources exist in the mobile gadgets. For offering effective medicinal services, in this article, an online medical decision support system (OMDSS) is introduced for chronic kidney disease (CKD) prediction. The presented model involves a set of stages namely data gathering, preprocessing, and classification of medical data for the prediction of CKD. For classification, logistic regression (LR) model is applied for classifying the data instances into CKD and non‐CKD. In addition, for tuning the parameters of LR, Adaptive Moment Estimation (Adam), and adaptive learning rate optimization algorithm is applied. The performance of the introduced model is examined using a benchmark CKD dataset. The experimental outcome observed the superior characteristics of the presented model on the applied dataset.
Lack of miR‐1246 in small extracellular vesicle blunts tumorigenesis of laryngeal carcinoma cells by regulating Cyclin G2
Authors: Huang Qiang , Hsueh Chi‐Yao , Guo Yang , Wu Xiu‐Fa , Li Jiao‐Yu , Zhou Liang 
Published: March 2020

AbstractSmall extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR‐1246 in LSCC tissues and plasma sEV was examined. The internalization ability of sEV was determined by uptake assay. Then, the source and purity of sEV were checked through RNase and/or pharmacological inhibitors application. The invasion, migration, proliferation, and cell cycle assays were used to determine the altered abilities of miR‐1246 in sEV in LSCC. Finally, target gene of miR‐1246, Cyclin G2 (CCNG2), was stained immunohistochemically. In addition, the relationship between CCNG2 and clinicopathological features of patients was analyzed. We found that miR‐1246 was higher in LSCC tissues and plasma sEV. MiR‐1246 was enriched in sEV rather than soluble form. SEV could be internalized into adjacent cells. Lack of miR‐1246 in sEV abrogated the tumorigenesis of LSCC. Furthermore, CCNG2 knockdown arrested the cell cycle and correlated to clinicopathological features and prognosis of LSCC patients. Taken together, we found that the function of sEV miR‐1246 by regulating CCNG2 is responsible for LSCC advancement with emphasis on the main source of miR‐1246 mainly root in sEV rather than in soluble form.
How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
Authors: Yaghoubi Sajad , Najminejad Hamid , Dabaghian Mehran , Karimi Mohammad Hossein , Abdollahpour‐Alitappeh Meghdad , Rad Fariba , Mahi‐Birjand Motahareh , Mohammadi Shiva , Mohseni Fatemeh , Sobhani Lari Mohammad , Teymouri Gholam Hossein , Rigi Yousofabadi Esmat , Salmani Abbas , Bagheri Nader 
Published: March 2020

AbstractExosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell‐derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.