bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholders’ perceptions of sustainable development of higher education institutions: an intellectual capital approach
Authors: Pedro Eugénia de Matos , Leitão João , Alves Helena 
Published: June 2020

Purpose
This study aims to identify stakeholders’ perceptions of the effects associated with different components of intellectual capital (IC) on the sustainable development (SD) practices of higher education institutions (HEIs).

Design/methodology/approach
The empirical approach uses a structural equation model to provide new empirical findings in relation to 738 students and 587 lecturers/researchers at seven Portuguese state HEIs through quantitative research.

Findings
The results obtained are, firstly, important contributions to the literature on the IC and SD practices of HEIs, as a relationship between these two constructs is confirmed, especially through relational capital (RC) and structural capital (SC). Secondly, the stakeholders considered show different perceptions of the influence of the components of HEIs’ IC on these institutions’ SD practices, and thirdly, perception of the economic dimension is most influenced.

Practical implications
The empirical findings indicate the need to provide better information about HEIs’ policies and practices of SD and how the latter contribute to the SD of the institution and its region of influence.

Originality/value
No previous studies investigate students and teachers/researchers’ perceptions of the social, environmental, economic and organizational dimensions of SD in HEIs and at the same time how those perceptions can be influenced by the components of IC (e.g. human capital, SC, RC) in that institution.
Supporting entrepreneurs when it matters: optimising capital allocation for impact
Authors: Burton James 
Published: June 2020

PurposeThis paper argues that policymakers and academics should place more emphasis on maximising the additional benefit created by entrepreneurial support programs and impact investments. It demonstrates a robust approach to advancing this field of research by using qualitative methods to determine the variables that may predict the additional benefit a firm will gain from funding.Design/methodology/approachThe research is based on 60 semi-structured interviews averaging 1.5 h each; 45 with entrepreneurs that did or did not receive funding from a business plan competition in Nigeria, 15 with relevant elites. Detailed World Bank panel data on program participants further validated responses and supported conclusions.FindingsNumerous factors that may explain additional benefit were uncovered, including those that vary the need for external funding and those that vary access to it.Research limitations/implicationsQualitative methods explored variables previously assumed to be unobservable. Future studies are necessary to test the results quantitatively.Social implicationsUnderstanding the characteristics that indicate ex ante which firms would most benefit from support will help policymakers, impact investors and development institutions to more effectively allocate capital.Originality/valueThis paper addresses the paucity of research into increasing additional impact and demonstrates the value of pursuing it. Methods used to suggest additionality variables for such programs and many of the factors highlighted are unique to this study. The research is also based on unique access to the participants and un-anonymised data from a significant World Bank study, and on substantially more interviews than previous papers.
How does finance influence labour market outcomes? A review of empirical studies
Authors: Heil Mark 
Published: June 2020

PurposeThis paper reviews economic studies on the effects of various aspects of finance on labour market outcomes.Design/methodology/approachThe paper is a systematic literature review that reviews the weight of the evidence on the relationships between specific elements of finance and labour outcomes. The review is divided into three major sections: (1) job quantity and job quality; (2) distributional effects; and (3) resilience and adaptability.FindingsFinance interacts with labour market institutions to jointly determine labour outcomes. Firm financial structures influence their labour practices – highly leveraged firms show greater employment volatility during cyclical fluctuations, and leverage strengthens firm bargaining power in labour negotiations. Bank deregulation has mixed impacts on labour depending upon the state of prior bank regulations and labour markets. Leveraged buyouts tend to dampen acquired-firm job growth as they pursue labour productivity gains. The shareholder value movement may contribute to short-termism among corporate managers, which can divert funds away from firm capital accumulation toward financial markets, and crowd out productive investment. Declining wage shares of national income in most OECD countries since 1990 may be driven in part by financial globalisation. The financial sector contributes to rising income concentration near the top of the distribution in developed countries. The availability of finance is associated with increased reallocation of labour, which may either enhance or impede productivity growth. Finally, rising interest rate environments and homeowners with mortgage balances that exceed their home's value may reduce labour mobility rates.Originality/valueThis review contributes to the understanding of the effects of finance on labour by reviewing and synthesising a large volume of literature.
The impact of customer knowledge management capability on project performance-mediating role of strategic agility
Authors: Haider Syed Arslan , Kayani Umar Nawaz 
Published: June 2020

PurposeThe purpose of this study is to examine the relationship between the customer knowledge management capability (CKMC) on project performance through strategic agility in the context project based software companies of Pakistan. The aim of the paper is to find out whether and how is customer knowledge beneficial for project performance and recognized as the important source of advancement of the knowledge management (KM) theory and the essential subject in practical ground.Design/methodology/approachIn this study, non-probability, simple random sampling method was used to collect the data because it excludes bias from the data collection process. Although, the population of this research includes 307 employees working in different 30 public and private projects based software firms, operating in twin cities Rawalpindi, Islamabad. The respondents are project supervisors, team members, customers working on these different projects. Because of time limitation data has been collected within four months (i.e. November 2018 to February 2019) for this study, it is not time-lagged study and the data were collected at one time, so the design is cross-sectional in nature. The analysis was established using partial least squares-structural equation modeling (Smart PLS-SEM v.3.2.8) software to test hypotheses.FindingsThe results revealed the structural equation modeling that the components creating, transferring, integrate and influence ensure the most significant job in clarifying the customer knowledge and enhancing the capability to understand the customer needs and want which lead to decrease project delay, over consumption of the budget and directly lead to increase the project performance. The analyzed results also successfully justified the gap of this research study by showing the significant relationship between CKMC and project performance, also the indirect effect of CKMC through strategic agility on project performance more than its direct effect. So, the strategic agility plays positive and significant mediating role between CKMC and project performance, therefore the all sub-hypothesis and primary hypothesis were accepted.Originality/valueThis study sets the context with a brief summary of the key characteristics of the CKMC to improve the new product performance, enhance product/service quality, also reduce costs and enhance the competitiveness of organizations. Organization ought to acknowledge how to use KM to generate their revenues and achieve their goals. However, available techniques and methodology to measure the sufficiency are dissatisfying and consistent need for assessments and evaluations of this issue are felt.
The diffusion of innovative diabetes technologies as a fundamental cause of social inequalities in health. The Nord‐Trøndelag Health Study, Norway
Authors: Weiss Daniel , Sund Erik R. , Freese Jeremy , Krokstad Steinar 
Published: June 2020

AbstractThis study investigates patterns of adoption and diffusion of innovative health technologies by socioeconomic status (SES) in order to assess the extent to which these technologies may be a fundamental cause of health‐related inequalities. Quantitative analyses examined SES‐based inequalities in the adoption and diffusion of diabetes technologies. Diabetes data from three panels of the Nord‐Trøndelag Health Study (HUNT), Norway, were combined with income and education data. Cross‐sectional and longitudinal regression analyses were used to examine relevant inequalities. Cross‐sectional analyses suggest often present SES‐based gradients in the adoption of diabetes technologies, favouring high‐SES groups. Statistically significant differences (p ≤ 0.05) were most often present when technologies were new. In a cohort followed from 1984 to 1997, high SES individuals were more likely to adopt insulin injection technologies but, due to modest sample sizes, these inequalities were not statistically significant after adjusting for age, gender, and duration of illness. Moreover, compared to low SES individuals, high SES individuals are more active users of diabetes technologies. Results suggest that SES‐based variations in access and use of innovative health technologies could act as a mechanism through which inequalities are reproduced. This study provides a discussion of mechanisms and a methodological foundation for further investigation.
Assessing the potential for up‐cycling recovered resources from anaerobic digestion through microbial protein production
Authors: Verbeeck Kristof , De Vrieze Jo , Pikaar Ilje , Verstraete Willy , Rabaey Korneel 
Published: June 2020

SummaryAnaerobic digesters produce biogas, a mixture of predominantly CH4 and CO2, which is typically incinerated to recover electrical and/or thermal energy. In a context of circular economy, the CH4 and CO2 could be used as chemical feedstock in combination with ammonium from the digestate. Their combination into protein‐rich bacterial, used as animal feed additive, could contribute to the ever growing global demand for nutritive protein sources and improve the overall nitrogen efficiency of the current agro‐ feed/food chain. In this concept, renewable CH4 and H2 can serve as carbon‐neutral energy sources for the production of protein‐rich cellular biomass, while assimilating and upgrading recovered ammonia from the digestate. This study evaluated the potential of producing sustainable high‐quality protein additives in a decentralized way through coupling anaerobic digestion and microbial protein production using methanotrophic and hydrogenotrophic bacteria in an on‐farm bioreactor. We show that a practical case digester handling liquid piggery manure, of which the energy content is supplemented for 30% with co‐substrates, provides sufficient biogas to allow the subsequent microbial protein as feed production for about 37% of the number of pigs from which the manure was derived. Overall, producing microbial protein on the farm from available methane and ammonia liberated by anaerobic digesters treating manure appears economically and technically feasible within the current range of market prices existing for high‐quality protein. The case of producing biomethane for grid injection and upgrading the CO2 with electrolytic hydrogen to microbial protein by means of hydrogen‐oxidizing bacteria was also examined but found less attractive at the current production prices of renewable hydrogen. Our calculations show that this route is only of commercial interest if the protein value equals the value of high‐value protein additives like fishmeal and if the avoided costs for nutrient removal from the digestate are taken into consideration.
Circ_0072088 promotes the development of non‐small cell lung cancer via the miR‐377‐5p/NOVA2 axis
Authors: Tan Zhaofeng , Cao Fang , Jia Bin , Xia Lei 
Published: June 2020

BackgroundNon‐small cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death globally. This study aimed to disclose the role of circular RNA circ_0072088 in NSCLC and illustrate its potential mechanism.MethodsQuantitative real‐time polymerase chain reaction (qRT‐PCR) was applied to detect the expression of circ_0072088, zinc finger RNA binding protein (ZFR), microRNA‐377‐5p (miR‐377‐5p) and NOVA alternative splicing regulator 2 (NOVA2). The viability, colony formation, cell cycle, migration and invasion of NSCLC cells were measured by cell counting kit‐8 (CCK8) assay, colony formation assay, flow cytometry, wound healing assay and transwell invasion assay. Western blot assay was employed to examine the protein levels of proliferating cell nuclear antigen (PCNA), Cyclin D1, matrix metallopeptidase 2 (MMP2), MMP9 and NOVA2. The downstream targets of circ_0072088 and miR‐377‐5p were searched through using circular RNA Interactome and TargetScan databases, and the interaction between miR‐377‐5p and circ_0072088 or NOVA2 was confirmed by dual‐luciferase reporter assay and RNA immunoprecipitation (RIP) assay. in vivo tumor growth assay was used to evaluate the functions of circ_0072088 in the progression of NSCLC in vivo.ResultsGSE101586 dataset and the analysis of tissue specimens showed that circ_0072088 was aberrantly upregulated in tumor tissues of lung cancer and NSCLC. Circ_0072088 interference caused marked suppression on the proliferation and motility of NSCLC cells. Circ_0072088 could negatively regulate miR‐377‐5p through direct combination. Circ_0072088 contributed to the progression of NSCLC through sponging miR‐377‐5p. MiR‐377‐5p could directly interact with NOVA2, and the overexpression of NOVA2 overturned miR‐377‐5p‐mediated influence on NSCLC cells. Circ_0072088 facilitated the progression of NSCLC in vivo.ConclusionsCirc_0072088 facilitated the proliferation and metastasis of NSCLC cells through upregulating NOVA2 via functioning as a competitive endogenous RNA (ceRNA) for miR‐377‐5p.
Identification of unique clusters of T, dendritic, and innate lymphoid cells in the peritoneal fluid of ovarian cancer patients
Authors: Vazquez Jessica , Chavarria Melina , Lopez Gladys E. , Felder Mildred A. , Kapur Arvinder , Romo Chavez Antonio , Karst Nathan , Barroilhet Lisa , Patankar Manish S. , Stanic Aleksandar K. 
Published: June 2020

AbstractProblemWe hypothesize that activated peritoneal immune cells can be redirected to target ovarian tumors. Here, we obtain fundamental knowledge of the peritoneal immune environment through deep immunophenotyping of T cells, dendritic cells (DC), and innate lymphoid cells (ILC) of ovarian cancer patients.Method of studyT cells, DC, and ILC from ascites of ovarian cancer patients (n = 15) and peripheral blood of post‐menopausal healthy donors (n = 6) were immunophenotyped on a BD Fortessa cytometer using three panels—each composed of 16 antibodies. The data were analyzed manually and by t‐SNE/DensVM. CA125 levels were obtained from patient charts.ResultsWe observed decreased CD3+ T cells and a higher proportion of activated CD4+ and effector memory CD4+/CD8+ T cells, plasmacytoid DC, CD1c+ and CD141+ myeloid DC and CD56Hi NK cells in ascites. t‐SNE/DensVM identified eight T cell, 17 DC, and 17 ILC clusters that were unique in the ascites compared to controls. Hierarchical clustering of cell frequency distinctly segregated the T‐cell and ILC clusters from controls. Increased CA125 levels were associated with decreased CD8+/CD45RA+/CD45RO−/CCR7− T cells.ConclusionThe identified immune clusters serve as the basis for interrogation of the peritoneal immune environment and the development of novel immunologic modalities against ovarian cancer.
Worse progression of COVID‐19 in men: Is testosterone a key factor?
Authors: Giagulli Vito A. , Guastamacchia Edoardo , Magrone Thea , Jirillo Emilio , Lisco Giuseppe , De Pergola Giovanni , Triggiani Vincenzo 
Published: June 2020

AbstractBackgroundThe novel severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) disease 2019 (COVID‐19) seems to have a worse clinical course among infected men compared with women, thus highlighting concerns about gender predisposition to serious prognosis. Therefore, androgens, particularly testosterone (T), could be suspected as playing a critical role in driving this excess of risk. However, gonadal function in critically ill men is actually unknown, mainly because serum T concentration is not routinely measured in clinical practice, even more in this clinical context.ObjectiveTo overview on possible mechanisms by which serum T levels could affect the progression of COVID‐19 in men.MethodsAuthors searched PubMed/MEDLINE, Web of Science, EMBASE, Cochrane Library, Google, and institutional websites for medical subject headings terms and free text words referred to “SARS‐CoV‐2,” “COVID‐19,” “testosterone,” “male hypogonadism,” “gender” “immune system,” “obesity,” “thrombosis” until May 19th 2020.ResultsT, co‐regulating the expression of angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in host cells, may facilitate SARS‐CoV‐2 internalization. Instead, low serum T levels may predispose to endothelial dysfunction, thrombosis and defective immune response, leading to both impaired viral clearance and systemic inflammation. Obesity, one of the leading causes of severe prognosis in infected patients, is strictly associated with functional hypogonadism, and may consistently strengthen the aforementioned alterations, ultimately predisposing to serious respiratory and systemic consequences.Discussion and conclusionT in comparison to estrogen may predispose men to a widespread COVID‐19 infection. Low serum levels of T, which should be supposed to characterize the hormonal milieu in seriously ill individuals, may predispose men, especially elderly men, to poor prognosis or death. Further studies are needed to confirm these pathophysiological assumptions and to promptly identify adequate therapeutic strategies.
BMP‐6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis‐associated infertility
Authors: De Conto Emily , Matte Ursula , Cunha‐Filho João Sabino 
Published: June 2020

AbstractIntroductionOocyte competence and quality depend on communication between the oocyte and the cumulus and theca cells. In the preantral phase, the members of the transforming growth factor β (TGF‐β) superfamily are responsible for this communication and play an important role in folliculogenesis. Members of the TGF‐β superfamily are related to endometriosis (overexpression in the ectopic endometrium); however, few studies have explored these proteins as influencing fertility in endometriosis. Considering endometriosis‐related infertility and to better understand the role of the TGF‐β superfamily members in the antral phase in women with endometriosis, this research investigated the gene expression of the genes for ligands AMH, BMP‐6, GDF‐9, INHA, INHBB, and TGFβ3; receptors AMHR2, BMPR2, and TGFβR3; and intracellular signalling: SMAD3 and SMAD4.Material and methodsThe gene expression of AMH, BMP‐6, GDF‐9, INHA, INHBB, TGFβ3, AMHR2, BMPR2, TGFβR3, SMAD3, and SMAD4 in cumulus cells was investigated through quantitative real‐time PCR in a case‐control study including infertile women with and without peritoneal endometriosis undergoing in vitro fertilization.ResultsAge and outcomes of assisted reproduction were similar between the groups (P > .05). However, women with endometriosis showed reduced expression of BMP‐6 and SMAD4 (P < .05) in cumulus cells compared with the control group, other genes did not present altered gene expression in women with endometriosis (P > .05).ConclusionsThe reduced expression of BMP‐6 and SMAD4 in women with peritoneal endometriosis compared with the control group indicates that granulosa (cumulus) cell function could be altered in these women.
Carcass traits and meat quality of Texel lambs raised in Brachiaria pasture and feedlot systems
Authors: da Silva Pâmila Carolini Gonçalves , Brandão Ferreira Ítavo Camila Celeste , Vinhas Ítavo Luís Carlos , de Nadai Bonin Gomes Marina , Dias Feijó Gelson Luís , Monteiro Ferelli Kedma Leonora Silva , da Silva Heimbach Natália , da Silva Jonilson Araújo , de Melo Gleice Kelli Ayardes , Filgueira Pereira Marília Williani 
Published: June 2020

AbstractOur hypothesis suggests an improvement in carcass and meat quality of pasture‐finished animals by introducing concentrate feed into diets. This study aimed to evaluate the effect of different levels of protein‐energy supplementation on carcass and meat characteristics of Texel lambs raised on Brachiaria pastures, and compare the results with those obtained from confined animals. Thirty 2‐month‐old intact lambs were divided into five treatments: pasture with mineral supplementation, pasture containing daily supplies of 0.8, 1.6, and 2.4% BW protein‐energy supplementation, and confinement (reference treatment). All animals were slaughtered 104 days after the beginning of the experiment. Lambs submitted to 1.6% and 2.4% BW supplementation presented similar characteristics to animals kept in confinement and were superior to animals treated with 0 or 0.8% of BW supplementation levels (p < .05). Increases of subcutaneous fat thickness were verified for 0.0, 0.8, 1.6, 2.4% BW, and confinement treatments, being respectively of 0.25, 0.74, 1.61, 1.69, and 1.98. Conversely, treatments had no influence on meat physical‐chemical characteristics, being all considered moderately soft, juicy (tender), and with mild tastes and odors. Lambs raised on Brachiaria pastures have high‐quality meat, but more protein‐energy supplementation is needed to be an alternative for the feedlots for young animals.
Selection based on morphological features of porcine embryos produced by in vitro fertilization: Timing of early cleavages and the effect of polyspermy
Authors: Nguyen Hiep Thi , Dang‐Nguyen Thanh Quang , Somfai Tamas , Men Nguyen Thi , Viet Linh Nguyen , Xuan Nguyen Bui , Noguchi Junko , Kaneko Hiroyuki , Kikuchi Kazuhiro 
Published: June 2020

AbstractThe aim of this study was to examine whether a morphological approach is efficient for selecting high‐quality porcine embryos produced by in vitro fertilization (IVF) under high polyspermy conditions. Frozen‐thawed Meishan epididymal spermatozoa showing moderate and high polyspermy were subjected to IVF (1 × 105 sperms/ml). Under conditions of moderate polyspermy, 4‐cell embryos selected at 48 hr after IVF (single selection) and 8‐cell embryos selected at 79 hr after IVF from the collected 4‐cell embryos (double selection) showed high developmental competence. Likewise, 4‐ and 8‐cell embryos produced by IVF under high polyspermy conditions also showed high competence for development to blastocysts. However, blastocysts derived from high polyspermy conditions had significantly fewer cells than those produced under moderate polyspermy conditions. Furthermore, the frequency of nuclear and chromosomal abnormalities in 4‐ and 8‐cell embryos produced under conditions of high polyspermy was significantly (p < .05) higher in comparison to moderate polyspermy conditions. These findings suggest that although high polyspermy affects the frequency of nuclear and chromosomal anomalies in porcine IVF embryos, subsequent selection based on morphological features of 4‐ and 8‐cell embryos even under high polyspermy conditions, could be an alternative option for selecting porcine IVF embryos with high development ability.