bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect factors related to a high probability of hemodialysis independence in newly diagnosed multiple myeloma patients requiring hemodialysis
Authors: Song Jia , Jiang Fengjuan , Liu Hui , Ding Kai , Ren Yue , Li Lijuan , Wang Guojin , Shao Zonghong , Fu Rong 
Published: October 2019

AbstractBackgroundRenal failure is a severe complication of symptomatic myeloma, related to higher mortality. Recovery from dialysis dependence can lead to enormous survival benefits. We investigated the effect factors for probability of dialysis independence.MethodsRetrospective data on 45 newly diagnosed MM (NDMM) patients with serious renal impairment and requiring hemodialysis were analyzed. The statistical methods including logistic regression analysis, Kaplan‐Meier survival curves, the log‐rank test and the Cox proportional hazards model for survival analysis were used in our study.ResultsTwenty‐two of the 45 patients, who were on hemodialysis at diagnosis, became dialysis independence. In the logistic regression analysis, serum level of β2‐microglobulin, kidney disease history, involved free light chain, and achieving at least VGPR were significantly associated with reversibility from dialysis dependence. In addition, achieving hemodialysis discontinuation was related to better survival. The multivariate analyses demonstrated that reversibility from dialysis dependence, proteinuria < 3.5 g/24 h, and achieving at least VGPR were significantly associated with OS among NDMM patients requiring hemodialysis.ConclusionLower serum level of β2‐microglobulin and lower level of free light chain at diagnosis, achieving at least VGPR, and shorter kidney disease history are related to a high probability of dialysis independence in NDMM patients with serious renal failure requiring dialysis.
A contemporary medicolegal analysis of perioperative vision loss from 2007 to 2016
Authors: Du Amy , Saba Ramsey , Brovman Ethan Y. , Greenberg Penny , Urman Richard D. 
Published: October 2019

IntroductionPerioperative vision loss (POVL) is a rare but catastrophic event. Closed claim databases are useful for investigating risk factors of POVL to help guide practices in risk mitigation and risk management strategies.MethodsWe retrospectively analyzed the Controlled Risk Insurance Company (CRICO) Comparative Benchmarking System database for perioperative nerve injuries from when claims were closed between 2007 and 2016. We then extracted, deidentified, and analyzed all the POVL cases.ResultsOf 53 nerve injury claims closed between 2007 and 2016, we found 9 pertaining to POVL. Of these 9 cases, 100% resulted in permanent injury, 76% were associated with spine surgery, 89% of the patients were positioned prone intraoperatively, 67% were noted to have improper or missing documentation, and 56% of the patients claimed they were not informed of the risk of vision loss during preoperative consenting. Four of the 9 cases were settled, with a mean settlement amount of $906,250 (standard deviation, ± $745,647).ConclusionsPOVL often results in permanent injury with costly burden on the health care system. Risk reduction strategies need to be instituted on the provider and system level, involving a multidisciplinary health care team to develop and execute clinical protocols and patient communication strategies that will help prevent POVL.
Wildfire burnt area patterns and trends in Western Mediterranean Europe via the application of a concentration index
Authors: Royé Dominic , Tedim Fantina , Martin‐Vide Javier , Salis Michele , Vendrell Jordi , Lovreglio Raffaella , Bouillon Christophe , Leone Vittorio 
Published: October 2019

AbstractThe most widely used metrics to characterize wildfire regime and estimate the impact of wildfires are total burnt area (BA) and the number of fire events (FE). However, these are insufficient to analyse the threat to society of a new fire regime characterized by a higher occurrence of very large events. To overcome this weakness, we propose the use of a Concentration Index (CIB) which makes it possible to identify spatio‐temporal patterns. The frequency distribution of BA follows a negative exponential distribution almost everywhere, in which a small minority of FE is responsible of the majority of BA. In this article, the spatio‐temporal behaviour of BA is analysed in Western Mediterranean Europe, with particular focus on Portugal, Spain, France and Italy, using data from the European Forest Fire Information System and national wildfire databases. This is the first time that the CI has been applied to wildfire events. This research shows that, in most Mediterranean European countries, the amount of BA is increasingly related with a lower number of fires. The spatio‐temporal distribution of CIBshows high variability in all of the countries analysed in Europe. Portugal and Spain show increasing significant trends of CIB+ 7.6% (p‐value = 0.001) and + 1.3% per decade (p‐value = 0.003). Statistically significant correlations for Portugal, Spain and Italy are also found between the annual CIBand several teleconnection indices. The application of the CIBdemonstrates its discriminatory ability, which is a key point in detecting vulnerable areas and temporal trends under climate change.
Fillers as Heaters for Photothermal Polymerization upon NIR Light
Authors: Bonardi Aude heloise , Bonardi Fabrice , Dumur Frédéric , Gigmes Didier , Fouassier Jean Pierre , Lalevée Jacques 
Published: October 2019

AbstractPhoto‐induced thermal polymerization upon near‐infrared (NIR) light irradiation has been reported in the literature. In this approach, a component able to convert the NIR light into heat must be used in combination with a thermal initiator to initiate the free‐radical polymerization of (meth)acrylates. In recent studies, some absorbers have been presented as very efficient heat generators (called heaters). In the present work, different fillers are investigated as heaters and compared to organic NIR absorbers. An alkoxyamine (e.g., BlocBuilder‐MA) is used as thermal initiator and is dissociated by the heat generated by the NIR photoexcitation of the fillers. In the present work, several fillers are examined: graphene oxide, graphene nanoplatelets, multi‐walled carbon nanotubes, and silicon carbide. Due to the energy of the photon delivered, NIR light curing is challenging but offers several advantages compared to visible light. The most interesting feature is the deeper penetration of the light inside the photocurable resin, enabling the polymerization of thick samples. Parallel to this, incorporation of fillers in resins allows unique access to composites through photothermal polymerization of (meth)acrylates. Three different wavelengths of irradiation have been studied: 785, 940, and 1064 nm.
A 60‐GHz variable gain amplifier with low phase and OP1dB variation
Authors: Byeon Chul Woo , Park Chul Soon 
Published: October 2019

AbstractThis article presents a 60 GHz variable gain amplifier (VGA) with a low phase and output 1‐dB gain compression point (OP1dB) variation for phased‐array applications. The VGA employs a two‐stage modified current‐steering cascode. Implemented in 0.18‐μm SiGe BiCMOS technology, the VGA has a gain control range of 20.4 dB with a maximum gain of 17.7 dB at 60 GHz. The OP1dB variation is only 2.3 dB for all gain states at 60 GHz with a DC power consumption of 50 mW, and the measured phase variation is less than 4.8° at 57 to 66 GHz.
Radar‐based climatology of damaging hailstorms in Brisbane and Sydney, Australia
Authors: Warren Robert A. , Ramsay Hamish A. , Siems Steven T. , Manton Michael J. , Peter Justin R. , Protat Alain , Pillalamarri Anu 
Published: October 2019

AbstractSevere hailstorms represent some of Australia's most costly natural disasters. In particular, the densely populated east‐coast cities of Brisbane and Sydney have both been impacted by events that individually produced over AU$1 billion in insured losses. In this study, the frequency of damaging hailstorms in these regions is assessed over an eight‐year period using single‐polarisation radar observations. Reflectivity data from multiple radars are carefully calibrated and merged to produce daily grids of MESH (the maximum expected size of hail) at 1 km spatial resolution. Neighbourhood contingency tables are then used to define an optimal MESH threshold for identifying damaging hail events. This analysis makes use of a unique insurance dataset, comprising building‐scale exposure and claim data over a multi‐year period. Overall, damaging hailstorms occur on an average of 26 and 32 days per year in the Brisbane and Sydney regions, respectively. The actual cities of Brisbane and Sydney both experience about five damaging hailstorms annually. In both regions, the highest hail frequencies occur along the coastal slopes of the Great Dividing Range, with more localised maxima highlighting the potential role of mesoscale circulations in storm initiation and intensification. For Brisbane, the seasonal cycle shows a pronounced peak in December, while in Sydney hail frequencies are high throughout the warm season (November–March). This difference reflects the distinct seasonal cycles of convective instability in the two regions. Consistent with previous studies, the combination of CAPE and deep‐layer shear is found to provide reasonable discrimination of environments conducive to severe hailstorms.
A Facile Microwave Assisted TEMPO/NaOCl/Oxone (KHSO5) Mediated Micron Cellulose Oxidation Procedure: Preparation of Two Nano TEMPO‐Cellulose Forms
Authors: Dachavaram Soma Shekar , Moore John P. , Bommagani Shobanbabu , Penthala Narsimha R. , Calahan Julie L. , Delaney Sean P. , Munson Eric J. , Batta‐Mpouma Joseph , Kim Jin‐Woo , Hestekin Jamie A. , Crooks Peter A. 
Published: October 2019

AbstractAn efficient and rapid method is established for micron cellulose (1, 20 microns) oxidation utilizing Oxone (KHSO5) in combination with 2,2,6,6‐tetramethylpiperidinyl‐1‐oxyl (TEMPO) and NaOCl in aqueous NaHCO3 solution (pH 7.5 to 8.5) under microwave irradiation. This method affords two different forms of nano TEMPO‐cellulose, that is, a water‐insoluble form (Form‐I, 14 nm) and a water‐soluble form (Form‐II, 8 nm). Cellulose oxidation utilizing this Oxone methodology has advantages over other methodologies, which include low cost and formation of two nano TEMPO‐cellulose forms over a rapid reaction time utilizing microwave irradiation conditions. TEMPO‐cellulose forms are characterized by FT‐IR, NMR, solid state 13C‐NMR, and by elemental analysis. The TEMPO‐cellulose forms morphology is studied by scanning electron microscopy analysis. The average fiber width and length of TEMPO‐cellulose materials are determined in nanometer range by transmission electron microscopy analysis and the surface charge is identified by zeta potential.
Investigation of flexural and shear behaviors of biaxial voided slabs containing steel cages
Authors: Amoushahi Khouzani Mohsen , Zeynalian Mehran , Hashemi Mahmoud , Mostofinejad Davood , Farahbod Farhang 
Published: October 2019

AbstractIn some of biaxial voided slabs, spherical or ellipsoidal plastic balls enclosed in steel cages are used to eliminate ineffective concrete. To investigate the bending and shear behavior of this system, five full‐scale specimens were cast including two bending specimens for investigating bending capacity and cracking distribution as well as three shear specimens used to study the shear capacity, cracking distribution, and concrete casting effect on the shear behavior. Moreover, the effects of the steel cage rods were studied on the bending and shear capacity. It was found that while both solid and biaxial voided specimens exhibited almost similar failure mode, both the bending and shear capacity of biaxial voided specimens were affected by the steel cages. In contrast, the voided specimens exhibited a significantly lower shear capacity than the solid ones while the different concrete casting methods had no effects on the capacity and behavior of biaxial voided specimens. Finally, a comparison was made with experimental results and ACI 318‐14, MC 2010, and Eurocode 2 recommendations.
Mechanisms of secretion and spreading of pathological tau protein
Authors: Brunello Cecilia A. , Merezhko Maria , Uronen Riikka-Liisa , Huttunen Henri J. 
Published: October 2019

AbstractAccumulation of misfolded and aggregated forms of tau protein in the brain is a neuropathological hallmark of tauopathies, such as Alzheimer’s disease and frontotemporal lobar degeneration. Tau aggregates have the ability to transfer from one cell to another and to induce templated misfolding and aggregation of healthy tau molecules in previously healthy cells, thereby propagating tau pathology across different brain areas in a prion-like manner. The molecular mechanisms involved in cell-to-cell transfer of tau aggregates are diverse, not mutually exclusive and only partially understood. Intracellular accumulation of misfolded tau induces several mechanisms that aim to reduce the cellular burden of aggregated proteins and also promote secretion of tau aggregates. However, tau may also be released from cells physiologically unrelated to protein aggregation. Tau secretion involves multiple vesicular and non-vesicle-mediated pathways, including secretion directly through the plasma membrane. Consequently, extracellular tau can be found in various forms, both as a free protein and in vesicles, such as exosomes and ectosomes. Once in the extracellular space, tau aggregates can be internalized by neighboring cells, both neurons and glial cells, via endocytic, pinocytic and phagocytic mechanisms. Importantly, accumulating evidence suggests that prion-like propagation of misfolding protein pathology could provide a general mechanism for disease progression in tauopathies and other related neurodegenerative diseases. Here, we review the recent literature on cellular mechanisms involved in cell-to-cell transfer of tau, with a particular focus in tau secretion.
Jump performance in male and female football players
Authors: Arundale Amelia J. H. , Kvist Joanna , Hägglund Martin , Fältström Anne 
Published: October 2019

Abstract

Purpose
To examine differences between men and women football players in clinically feasible jumping measures.

Methods
Female football players (N = 46, ages 16–25) were matched based on age, training frequency, and playing position with 46 male players. All players performed the tuck jump and drop vertical jump (DVJ). DVJ was assessed quantitatively for valgus knee motion and probability of a high peak knee abduction moment (pKAM), as well as sagittal plane hip, knee, and ankle angles, and qualitatively with visual assessment of the player’s knees upon landing; graded as good, reduced, or poor control.

Result
Women had higher total tuck jump scores (5 ± 2) (more technique flaws), than men (3 ± 2, P < 0.01). The quantitative analysis of the DVJ found that men had greater asymmetries between limbs, but women landed bilaterally in more knee valgus (interaction P = 0.04, main effect of sex P = 0.02). There was no difference in pKAM (interaction n.s.). Women also landed in less hip flexion (P = 0.01) and ankle dorsiflexion (P = 0.01) than men. The qualitative DVJ analysis found that more women (48%) had poor knee control compared to men (11%, P < 0.01).

Conclusions
The results indicate that women perform worse on the tuck jump assessment than men. The results support previous findings that women land in more knee valgus than men, but also found that men may have larger asymmetries in knee valgus. These results from clinically feasible measures provide some suggestions for clinicians to consider during ACL reconstruction rehabilitation to enhance performance.
Sulfide oxidation in deep Baltic Sea sediments upon oxygenation and colonization by macrofauna
Authors: Bonaglia Stefano , Marzocchi Ugo , Ekeroth Nils , Brüchert Volker , Blomqvist Sven , Hall Per O. J. 
Published: October 2019

Abstract
Coastal and shelf sediments affected by transient or long-term bottom water anoxia and sulfidic conditions undergo drastic changes in macrofauna communities and abundances. This study investigates how early colonization by two macrofaunal functional traits (epifauna vs. infauna) affects oxygen, sulfide, and pH dynamics in anoxic sediment upon recent bottom water oxygenation. Large mesocosms (area 900 cm2) with 150-m-deep Baltic Sea soft sediments were exposed to three treatments: (1) no animals; (2) addition of 170 polychaetes (Marenzelleria arctia); (3) addition of 181 amphipods (Monoporeia affinis). Porewater chemistry was investigated repeatedly by microsensor profiling over a period of 65 days. Colonization by macrofauna did not significantly deepen penetration of oxygen compared to the animal-free sediment. Bioturbation by M. affinis increased the volume of the oxidized, sulfide-free sediment by 66% compared to the animal-free control already after 13 days of incubation. By the end of the experiment M. affinis and M. arctia increased the oxidized sediment volume by 87 and 35%, respectively. Higher efficiency of epifaunal amphipods in removing hydrogen sulfide than deep-burrowing polychaetes is likely due to more substantial re-oxidation of manganese and/or nitrogen compounds associated with amphipod mixing activity. Our results thus indicate that early colonization of different functional groups might have important implications for the later colonization by benthic macrofauna, meiofauna and microbial communities that benefit from oxidized and sulfide-free sediments.
Mouse model of the human serotonin transporter-linked polymorphic region
Authors: Piszczek Lukasz , Memoli Simone , Raggioli Angelo , Viosca José , Rientjes Jeanette , Hublitz Philip , Czaban Weronika , Wyrzykowska Anna , Gross Cornelius 
Published: October 2019

AbstractGenetic factors play a significant role in risk for mood and anxiety disorders. Polymorphisms in genes that regulate the brain monoamine systems, such as catabolic enzymes and transporters, are attractive candidates for being risk factors for emotional disorders given the weight of evidence implicating monoamines involvement in these conditions. Several common genetic variants have been identified in the human serotonin transporter (5-HTT) gene, including a repetitive sequence located in the promoter region of the locus called the serotonin transporter-linked polymorphic region (5-HTT-LPR). This polymorphism has been associated with a number of mental traits in both humans and primates, including depression, neuroticism, and harm avoidance. Some, but not all, studies found a link between the polymorphism and 5-HTT levels, leaving open the question of whether the polymorphism affects risk for mental traits via changes in 5-HTT expression. To investigate the impact of the polymorphism on gene expression, serotonin homeostasis, and behavioral traits, we set out to develop a mouse model of the human 5-HTT-LPR. Here we describe the creation and characterization of a set of mouse lines with single-copy human transgenes carrying the short and long 5-HTT-LPR variants. Although we were not able to detect differences in expression between the short and long variants, we encountered several technical issues concerning the design of our humanized mice that are likely to have influenced our findings. Our study serves as a cautionary note for future studies aimed at studying human transgene regulation in the context of the living mouse.
On Total Regularity of Mixed Graphs with Order Close to the Moore Bound
Authors: Tuite James , Erskine Grahame 
Published: October 2019

AbstractThe undirected degree/diameter and degree/girth problems and their directed analogues have been studied for many decades in the search for efficient network topologies. Recently such questions have received much attention in the setting of mixed graphs, i.e. networks that admit both undirectededgesand directedarcs. The degree/diameter problem for mixed graphs asks for the largest possible order of a network with diameterk, maximum undirected degree$$\le r$$≤rand maximum directed out-degree$$\le z$$≤z. Similarly one can search for the smallest possiblek-geodetic mixed graphs with minimum undirected degree$$\ge r$$≥rand minimum directed out-degree$$\ge z$$≥z. A simple counting argument reveals the existence of a natural bound, theMoore bound, on the order of such graphs; a graph that meets this limit is amixed Moore graph. Mixed Moore graphs can exist only for$$k = 2$$k=2and even in this case it is known that they are extremely rare. It is therefore of interest to search for graphs with order one away from the Moore bound. Such graphs must be out-regular; a much more difficult question is whether they must be totally regular. For$$k = 2$$k=2, we answer this question in the affirmative, thereby resolving an open problem stated in a recent paper of López and Miret. We also present partial results for largerk. We finally put these results to practical use by proving the uniqueness of a 2-geodetic mixed graph with order exceeding the Moore bound by one.
Radiomics for diagnosis of dual-phenotype hepatocellular carcinoma using Gd-EOB-DTPA-enhanced MRI and patient prognosis
Authors: Huang Xialing , Long Liling , Wei Jieqin , Li Yajuan , Xia Yuwei , Zuo Panli , Chai Xiangfei 
Published: October 2019

Abstract

Purpose
To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) and investigate the use of radiomics to establish an image-based signature for preoperative differential diagnosis.

Methods
This study included 50 patients with a postoperative pathological diagnosis of DPHCC (observation group) and 50 patients with CK7- and CK19-negative HCC (control group) who attended our hospital between January 2015 and December 2018. All patients underwent Gd-EOB-DTPA-enhanced MRI within 1 month before surgery. Arterial phase (AP), portal venous phase (PVP), delayed phase (DP) and hepatobiliary phase (HBP) images were transferred into a radiomics platform. Volumes of interest covered the whole tumor. The dimensionality of the radiomics features were reduced using LASSO. Four classifiers, including multi-layer perceptron (MLP), support vector machines (SVM), logistic regression (LR) and K-nearest neighbor (KNN) were used to distinguish DPHCC from CK7- and CK19-negative HCC. Kaplan–Meier survival analysis was used to assess 1-year disease-free survival (DFS) and overall survival (OS) in the observation and control groups.

Results
The best preoperative diagnostic power for DPHCC will likely be derived from a combination of different phases and classifiers. The sensitivity, specificity and accuracy of LR in PVP (0.740, 0.780, 0.766), DP (0.893, 0.700, 0.798), HBP (0.800, 0.720, 0.756) and MLP in PVP (0.880, 0.720, 0.798) were better performance. The 1-year DFS and OS of the patients in the observation group were 69% and 78%, respectively. The 1-year DFS and OS of the patients in the control group were 83% and 85%, respectively. Kaplan–Meier survival analysis showed no statistical difference in DFS and OS between groups (P = 0.231 and 0.326), but DFS and OS were numerically lower in patients with DPHCC.

Conclusion
The radiomics features extracted from Gd-EOB-DTPA-enhanced MR images can be used to diagnose preoperative DPHCC. DPHCC is more likely to recur and cause death than HCC, suggesting that active postoperative management of patients with DPHCC is required.