bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emergence of Class Politics in Nineteenth-Century Massachusetts
Authors: Gershenson Carl E. 
Published: August 2020

AbstractHow do economic and social position structure partisan affiliation? While neo-Durkheimian treatments of class and political behavior suggest the potential for extreme variability in the social bases of partisan affiliation, data limitations have largely restricted quantitative studies of this relationship to the postwar era. This temporal limitation restricts variation in observable social structure, thus limiting the ability of analysts to assess theoretical explanations. To address this gap, I introduce novel data on occupation and ethnicity for more than 20,000 Massachusetts state legislators in the nineteenth century. This allows me to find the “best fit” model for the social bases of party affiliation in four distinct periods in Massachusetts’ political history. I show that the Massachusetts political system transitioned from a system of occupational cleavages to proto-class cleavages between the First Party System (1795–1826) and Second Party System (1835–54). The Civil War and Reconstruction Era (1855–77) was characterized by the emergence of an ethnic cleavage, but near-modern class divisions emerged as the strongest predictors of legislators’ party affiliations for the remainder of the Third Party System (1878–93). Combined with historiographical accounts of the nineteenth century, these analyses suggest that the emergence of class politics requires intermediary organizations such as unions and professional associations, the liberalization of economic laws and regulation, and the increasingly unequal distribution of productive property.
Solar Wind Conditions During the First 42 Months of Magnetospheric Multiscale Mission
Authors: Lai H. R. , Russell C. T. , Jia Y. D. , Blanco‐Cano X. 
Published: August 2020

AbstractKnowledge of the solar wind conditions is important to study the magnetosphere by missions, such as Magnetospheric Multiscale (MMS) and the Time History of Events and Macroscale Interactions during Substorms (THEMIS). We examine the magnetic field and plasma data obtained by three solar wind monitors, ACE, Wind, and DSCOVR to check the consistency and survey the statistical properties of the solar wind during 2015–2018, the first 42 months of the MMS mission. In the consistency study, we exclude the effect of limited cross‐flow correlation lengths of solar wind properties and confirmed that the magnetic field measurements from different spacecraft are consistent on average. We also suggest that ACE and Wind measurements are best used for the temperature and velocity data; while for density measurements, DSCOVR and Wind data should be used when available. In the statistical study, by comparing the recent data with that in 2008, we find that the magnetic field conditions are generally the same but the plasma properties have changed. On average, the MMS measurements are obtained when Earth is in a lower dynamic pressure and smaller plasma beta solar wind than that of previous studies. These 2015–2018 conditions favor the occurrence of magnetic reconnection, which assumes a great role in driving the dynamics of the magnetosphere.
Hedging for Privacy in Smart Water Meters
Authors: Salomons Elad , Sela Lina , Housh Mashor 
Published: August 2020

AbstractSmart water meters at household connections are being installed in large numbers throughout the world due to the benefits they are expected to bring to the water utilities and water consumers. Smart metering provides high‐resolution readings and promises benefits to the water utilities, such as demand forecasting, regulating time‐of‐use watering, and making intelligent operation and planning decisions. For the consumers, smart metering promises improved billing and demand reduction by providing detailed and timely information about their water use and early notification of possible water leaks in their premises. However, the fine‐grained information collected by smart meters raises growing concerns of privacy invasion due to personal behavior exposure (private activity, daily routine, etc.). Nevertheless, there is no readily available technology for protecting water consumers from revealing their in‐home private activities. Thus, a viable argument in favor of smart metering technologies will not be possible without proactively accounting for the associated privacy challenges. Here, we present a practical technology coupling a dedicated apparatus with a control model for increasing personal privacy. We quantify the level of privacy achieved using information‐theoretic criterion and an empirically based occupancy detection method between the smart meter readings and actual water use. Furthermore, we evaluate and compare privacy protection using the best effort approach previously developed for masking activities revealed from smart electricity meters. The main results reveal that simple control actions can disguise personal behavior patterns and, thus, hedge against privacy breach in smart water meters. Furthermore, we quantify the trade‐off between the size of the apparatus and the level of privacy protection it provides. Our results demonstrate how “privacy friendly” smart water metering technology could be implemented in real‐life systems and reduce the privacy concerns of water consumers.
Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre
Authors: Huang Huijun , Xu Changlu , Gao Jie , Li Bing , Qin Tiejun , Xu Zefeng , Ren Sirui , Zhang Yudi , Jiao Meng , Qu Shiqiang , Pan Lijuan , Hu Naibo , Liu Jinqin , Cai Wenyu , Zhang Yingnan , Wu Dan , Zhang Peihong , Gale Robert Peter , Huang Gang , Zhou Jiaxi , Shi Lihong , Xiao Zhijian 
Published: August 2020

AbstractThe underlying mechanisms and clinical significance of ineffective erythropoiesis in myelodysplastic syndromes (MDS) remain to be fully defined. We conducted the ex vivo erythroid differentiation of megakaryocytic-erythroid progenitors (MEPs) from MDS patients and discovered that patient-derived erythroblasts exhibit precocity and premature aging phenotypes, partially by inducing the pro-aging genes, like ERCC1. Absolute reticulocyte count (ARC) was chosen as a biomarker to evaluate the severity of ineffective erythropoiesis in 776 MDS patients. We found that patients with severe ineffective erythropoiesis displaying lower ARC (<20 × 109/L), were more likely to harbor complex karyotypes and high-risk somatic mutations (p < 0.05). Lower ARCs are associated with shorter overall survival (OS) in univariate analysis (p < 0.001) and remain significant in multivariable analysis. Regardless of patients of lower-risk who received immunosuppressive therapy or higher-risk who received decitabine treatment, patients with lower ARC had shorter OS (p < 0.001). Whereas no difference in OS was found between patients receiving allo-hematopoietic stem cell transplantations (Allo-HSCT) (p = 0.525). Our study revealed that ineffective erythropoiesis in MDS may be partially caused by premature aging and apoptosis during erythroid differentiation. MDS patients with severe ineffective erythropoiesis have significant shorter OS treated with immunosuppressive or hypo-methylating agents, but may benefit from Allo-HSCT.
Ischemia induces autophagy of endothelial cells and stimulates angiogenic effects in a hindlimb ischemia mouse model
Authors: Jeong In-Hye , Bae Woom-Yee , Choi Jae-Sun , Jeong Joo-Won 
Published: August 2020

AbstractAlthough peripheral artery disease (PAD) is a major health problem, there have been limited advances in medical therapies. In PAD patients, angiogenesis is regarded as a promising therapeutic strategy to promote new arterial vessels and improve perfusion of ischemic tissue. Autophagy plays a critical role in catabolic processes for cell survival under normal and stressful conditions and plays fundamental biological roles in various cellular functions. In the present study, we showed that autophagy in endothelial cells is important for the repair and regeneration of damaged tissues. In a hindlimb ischemia mouse model, autophagy was stimulated in endothelial cells of the quadriceps muscle, and adjacent cells proliferated and regenerated. The autophagy pathway was induced under prolonged hypoxia in endothelial cells, and autophagy increased angiogenic activities. Moreover, conditioned media from endothelial cells blocked autophagy and inhibited the proliferation of muscle cells, suggesting that autophagic stimulation in endothelial cells affects the survival of adjacent cells, such as muscle. Collectively, hypoxia/ischemia-induced autophagy angiogenesis, and the damaged tissue surrounded by neo-vessels was regenerated in an ischemia model. Therefore, we strongly suggest that stimulation of autophagy in endothelial cells may be a potent therapeutic strategy in severe vascular diseases, including PAD.
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
Authors: Lam Fred C. , Kong Yi Wen , Huang Qiuying , Vu Han Tu-Lan , Maffa Amanda D. , Kasper Ekkehard M. , Yaffe Michael B. 
Published: August 2020

AbstractProper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that deregulated transcription following BRD4 loss in cancer cells leads to the accumulation of RNA:DNA hybrids (R-loops) and collisions with the replication machinery causing replication stress and DNA damage. Whole genome BRD4 and γH2AX ChIP-Seq with R-loop IP qPCR reveals that BRD4 inhibition leads to accumulation of R-loops and DNA damage at a subset of known BDR4, JMJD6, and CHD4 co-regulated genes. Interference with BRD4 function causes transcriptional downregulation of the DNA damage response protein TopBP1, resulting in failure to activate the ATR-Chk1 pathway despite increased replication stress, leading to apoptotic cell death in S-phase and mitotic catastrophe. These findings demonstrate that inhibition of BRD4 induces transcription-replication conflicts, DNA damage, and cell death in oncogenic cells.
Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
Authors: Pinkard Otis , McFarland Sean , Sweet Thomas , Coller Jeff 
Published: August 2020

AbstractTransfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an emerging theme is that tRNA abundance and functionality can powerfully impact protein production rate, folding, activity, and messenger RNA stability. Importantly, however, the expression pattern of tRNAs is obliquely known. Here we present Quantitative Mature tRNA sequencing (QuantM-tRNA seq), a technique to monitor tRNA abundance and sequence variants secondary to RNA modifications. With QuantM-tRNA seq, we assess the tRNA transcriptome in mammalian tissues. We observe dramatic distinctions in isodecoder expression and known tRNA modifications between tissues. Remarkably, despite dramatic changes in tRNA isodecoder gene expression, the overall anticodon pool of each tRNA family is similar across tissues. These findings suggest that while anticodon pools appear to be buffered via an unknown mechanism, underlying transcriptomic and epitranscriptomic differences suggest a more complex tRNA regulatory landscape.
Fast electrical modulation of strong near-field interactions between erbium emitters and graphene
Authors: Cano Daniel , Ferrier Alban , Soundarapandian Karuppasamy , Reserbat-Plantey Antoine , Scarafagio Marion , Tallaire Alexandre , Seyeux Antoine , Marcus Philippe , Riedmatten Hugues de , Goldner Philippe , Koppens Frank H. L. , Tielrooij Klaas-Jan 
Published: August 2020

AbstractCombining the quantum optical properties of single-photon emitters with the strong near-field interactions available in nanophotonic and plasmonic systems is a powerful way of creating quantum manipulation and metrological functionalities. The ability to actively and dynamically modulate emitter-environment interactions is of particular interest in this regard. While thermal, mechanical and optical modulation have been demonstrated, electrical modulation has remained an outstanding challenge. Here we realize fast, all-electrical modulation of the near-field interactions between a nanolayer of erbium emitters and graphene, by in-situ tuning the Fermi energy of graphene. We demonstrate strong interactions with a >1000-fold increased decay rate for ~25% of the emitters, and electrically modulate these interactions with frequencies up to 300 kHz – orders of magnitude faster than the emitter’s radiative decay (~100 Hz). This constitutes an enabling platform for integrated quantum technologies, opening routes to quantum entanglement generation by collective plasmon emission or photon emission with controlled waveform.
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
Authors: Lu Jiahui , Cao Qin , Hughes Michael P. , Sawaya Michael R. , Boyer David R. , Cascio Duilio , Eisenberg David S. 
Published: August 2020

AbstracthnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils both under cellular stress and in mutated form in neurodegenerative conditions. Previous work established that the C-terminal low-complexity domain (LCD) of hnRNPA2 fibrillizes under stress, and missense mutations in this domain are found in the disease multisystem proteinopathy (MSP). However, little is known at the atomic level about the hnRNPA2 LCD structure that is involved in those processes and how disease mutations cause structural change. Here we present the cryo-electron microscopy (cryoEM) structure of the hnRNPA2 LCD fibril core and demonstrate its capability to form a reversible hydrogel in vitro containing amyloid-like fibrils. Whereas these fibrils, like pathogenic amyloid, are formed from protein chains stacked into β-sheets by backbone hydrogen bonds, they display distinct structural differences: the chains are kinked, enabling non-covalent cross-linking of fibrils and disfavoring formation of pathogenic steric zippers. Both reversibility and energetic calculations suggest these fibrils are less stable than pathogenic amyloid. Moreover, the crystal structure of the disease-mutation-containing segment (D290V) of hnRNPA2 suggests that the replacement fundamentally alters the fibril structure to a more stable energetic state. These findings illuminate how molecular interactions promote protein fibril networks and how mutation can transform fibril structure from functional to a pathogenic form.
Transition metal-like carbocatalyst
Authors: Luo Zhicheng , Nie Renfeng , Nguyen Vy T. , Biswas Abhranil , Behera Ranjan K. , Wu Xun , Kobayashi Takeshi , Sadow Aaron , Wang Bin , Huang Wenyu , Qi Long 
Published: August 2020

AbstractCatalytic cleavage of strong bonds including hydrogen-hydrogen, carbon-oxygen, and carbon-hydrogen bonds is a highly desired yet challenging fundamental transformation for the production of chemicals and fuels. Transition metal-containing catalysts are employed, although accompanied with poor selectivity in hydrotreatment. Here we report metal-free nitrogen-assembly carbons (NACs) with closely-placed graphitic nitrogen as active sites, achieving dihydrogen dissociation and subsequent transformation of oxygenates. NACs exhibit high selectivity towards alkylarenes for hydrogenolysis of aryl ethers as model bio-oxygenates without over-hydrogeneration of arenes. Activities originate from cooperating graphitic nitrogen dopants induced by the diamine precursors, as demonstrated in mechanistic and computational studies. We further show that the NAC catalyst is versatile for dehydrogenation of ethylbenzene and tetrahydroquinoline as well as for hydrogenation of common unsaturated functionalities, including ketone, alkene, alkyne, and nitro groups. The discovery of nitrogen assembly as active sites can open up broad opportunities for rational design of new metal-free catalysts for challenging chemical reactions.
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
Authors: Wu Shipo , Zhong Gongxun , Zhang Jun , Shuai Lei , Zhang Zhe , Wen Zhiyuan , Wang Busen , Zhao Zhenghao , Song Xiaohong , Chen Yi , Liu Renqiang , Fu Ling , Zhang Jinlong , Guo Qiang , Wang Chong , Yang Yilong , Fang Ting , Lv Peng , Wang Jinliang , Xu Junjie , Li Jianmin , Yu Changming , Hou Lihua , Bu Zhigao , Chen Wei 
Published: August 2020

AbstractThe unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.
Equi–size nesting of Platonic and Archimedean metal–organic polyhedra into a twin capsid
Authors: Gan Hongmei , Xu Na , Qin Chao , Sun Chunyi , Wang Xinlong , Su Zhongmin 
Published: August 2020

AbstractInspired by the structures of virus capsids, chemists have long pursued the synthesis of their artificial molecular counterparts through self–assembly. Building nanoscale hierarchical structures to simulate double-shell virus capsids is believed to be a daunting challenge in supramolecular chemistry. Here, we report a double-shell cage wherein two independent metal–organic polyhedra featuring Platonic and Archimedean solids are nested together. The inner (3.2 nm) and outer (3.3 nm) shells do not follow the traditional “small vs. large” pattern, but are basically of the same size. Furthermore, the assembly of the inner and outer shells is based on supramolecular recognition, a behavior analogous to the assembly principle found in double-shell viruses. These two unique nested characteristics provide a new model for Matryoshka–type assemblies. The inner cage can be isolated individually and proves to be a potential molecular receptor to selectively trap guest molecules.
Raman spectra of fine-grained materials from first principles
Authors: Popov Maxim N. , Spitaler Jürgen , Veerapandiyan Vignaswaran K. , Bousquet Eric , Hlinka Jiri , Deluca Marco 
Published: August 2020

AbstractRaman spectroscopy is an advantageous method for studying the local structure of materials, but the interpretation of measured spectra is complicated by the presence of oblique phonons in polycrystals of polar materials. Whilst group theory considerations and standard ab initio calculations are helpful, they are often valid only for single crystals. In this paper, we introduce a method for computing Raman spectra of polycrystalline materials from first principles. We start from the standard approach based on the (Placzek) rotation invariants of the Raman tensors and extend it to include the effect of the coupling between the lattice vibrations and the induced electric field, and the electro-optic contribution, relevant for polar materials like ferroelectrics. As exemplified by applying the method to rhombohedral BaTiO3, AlN, and LiNbO3, such an extension brings the simulated Raman spectrum to a much better correspondence with the experimental one. Additional advantages of the method are that it is general, permits automation, and thus can be used in high-throughput fashion.
CroSSED sequence, a new tool for 3D processing in geosciences using the free software 3DSlicer
Authors: Dorador Javier , Rodríguez-Tovar Francisco J. 
Published: August 2020

AbstractThe scientific application of 3D imaging has evolved significantly over recent years. These techniques make it possible to study internal features by non-destructive analysis. Despite its potential, the development of 3D imaging in the Geosciences is behind other fields due to the high cost of commercial software and the scarce free alternatives. Most free software was designed for the Health Sciences, and the pre-settled workflows are not suited to geoscientific materials. Thus, an outstanding challenge in the Geosciences is to define workflows using free alternatives for Computed Tomography (CT) data processing, promoting data sharing, reproducibility, and the development of specific extensions. We present CroSSED, a processing sequence for 3D reconstructions of CT data, using 3DSlicer, a popular application in medical imaging. Its usefulness is exemplified in the study of burrows that have low-density contrast with respect to the host sediment. For geoscientists who have access to CT data and wish to reconstruct 3D structures, this method offers a wide range of possibilities and contributes to open-science and applied CT studies.
Sub-trabecular strain evolution in human trabecular bone
Authors: Turunen Mikael J. , Le Cann Sophie , Tudisco Erika , Lovric Goran , Patera Alessandra , Hall Stephen A. , Isaksson Hanna 
Published: August 2020

AbstractTo comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distribution and its evolution during loading at the sub-trabecular level in trabecular bone tissue. Human cadaver trabecular bone samples were compressed in situ until failure, while imaging with high-resolution synchrotron radiation X-ray tomography. Digital volume correlation was used to determine the strains inside the trabeculae. Regions without emerging damage were compared to those about to crack. Local strains in close vicinity of developing cracks were higher than previously reported for a whole trabecular structure and similar to those reported for single isolated trabeculae. Early literature on bone fracture strain thresholds at the tissue level seem to underestimate the maximum strain magnitudes in trabecular bone. Furthermore, we found lower strain levels and a reduced ability to capture detailed crack-paths with increased image voxel size. This highlights the dependence between the observed strain levels and the voxel size and that high-resolution is needed to investigate behavior of individual trabeculae. Furthermore, low trabecular thickness appears to be one predictor of developing cracks. In summary, this study investigated the local strains in whole trabecular structure at sub-trabecular resolution in human bone and confirmed the high strain magnitudes reported for single trabeculae under loading and, importantly extends its translation to the whole trabecular structure.