bluuebunny/crossref_metadata_2025_split huggingface dataset:
The corruption of popular sovereignty
Authors: Issacharoff Samuel 
Published: October 2020

Abstract
Populism marks a departure from the central forms of democratic governance over the past two centuries. As opposed to the primacy of the legislative branch and of institutional actors, most notably political parties, populism tends toward the unilateral authority of a charismatic leader, ruling on the basis of an electoral mandate. This article starts from an understanding of populism as being grounded in political mobilization in disregard of the institutions of governance. Even more centrally, populist leaders try to dismantle institutional constraints to allow for greater individual discretionary power. This article looks to legal vulnerabilities that might allow the institutional framework of democracy to withstand the new populist assault. The central insight is that corruption might prove the means of checking governance by the new breed of caudillos, the strongman rule that stands in opposition to separation of powers limitations on the executive. Two forms of corruption are examined. The first is the attempt to subordinate the electoral system itself. The second is the use of state discretionary authority to push the boundaries of clientelism and ultimately outright corruption. Whereas questions of electoral integrity are more commonly checked by formal constitutional boundaries, the question of ordinary corruption surfaces with regularity under populism. The article offers reasons why this might be the product of a descent from clientelism to cronyism to outright capture of public resources for private gain. In turn, the article offers arguments for how corruption invites review by broader layers of judicial and prosecutorial authorities than constitutional law.
Jurisdiction of Tribunals to Settle Intra-EU Investment Treaty Disputes
Authors: Scheu Julian , Nikolov Petyo 
Published: October 2020

Abstract
The European Court of Justice (ECJ) made a ground-breaking shift away from the current system of investor–State dispute settlement (ISDS) by rendering its judgment in the matter of Achmea v Slovak Republic. However, since March 2018, a large and ever-growing number of investment tribunals have found that the Achmea judgment does not deprive them of arbitral jurisdiction. Against this background, the aim of the present article is to analyse the effects of the Achmea judgment on the jurisdiction of tribunals to settle intra-European Union (EU) investment treaty disputes. By taking due account of the reasoning conducted by the ECJ, the scope of the Achmea jurisprudence will be clarified. It is concluded that the incompatibility of intra-EU ISDS with EU law concerns all intra-EU investment treaties, including article 26 of the Energy Charter Treaty (ECT). On this basis, we ask whether, and to what extent, the applicability of the Achmea judgment is relevant to arbitral jurisdiction. Considering the law applicable to the arbitration agreement, we conclude that International Centre for Settlement of Investment Disputes (ICSID) tribunals and those seated outside the EU remain competent to settle intra-EU investment disputes. In contrast, the Achmea judgment renders ISDS clauses contained in intra-EU investment treaties inoperable if the tribunal is seated within the EU. The article closes with an outlook that puts these conclusions into perspective by considering recent developments such as the EU Member States’ ratification of a multilateral termination treaty.
Triport periareolar thoracoscopic surgery versus right minithoracotomy for repairing atrial septal defect in adults
Authors: Zheng Xiang-Xiang , Wang Ze-Yu , Ma Lu-Yao , Liu Hong- , Liu Huan- , Qin Jian-Wei , Shao Yong-Feng 
Published: October 2020

Abstract

OBJECTIVES
Our goal was to investigate the safety and feasibility of triport periareolar thoracoscopic surgery (TPTS) and its advantages in repairing adult atrial septal defect.

METHODS
Between January 2017 and January 2020, a total of 121 consecutive adult patients underwent atrial septal defect closure in our institution. Of these, 30 patients had TPTS and 31 patients had a right minithoracotomy (RMT). Operational data and clinical outcomes were compared between the 2 groups.

RESULTS
The total operation time, cardiopulmonary bypass time and aortic cross-clamp time in the TPTS group were slightly longer than those in the RMT group, but there were no differences between the 2 groups. Compared with the RMT group, the TPTS group showed a decrease in the volume of chest drainage in 24 h (98.6 ± 191.2 vs 222.6 ± 217.2 ml; P = 0.032) and a shorter postoperative hospital stay (6.5 ± 1.5 vs 8.0 ± 3.7 days; P = 0.042). The numeric rating scale on postoperative day 7 was significantly less in the TPTS group than in the RMT group (2.82 ± 1.14 vs 3.56 ± 1.42; P = 0.034). The patient satisfaction scale for the cosmetic results in the TPTS group was significantly higher than in the RMT group (4.68 ± 0.55 vs 4.22 ± 0.76; P = 0.012). No differences were found in postoperative complications. No in-hospital death or major adverse events occurred in the 2 groups.

CONCLUSIONS
TPTS is safe and feasible for the closure of adult atrial septal defect. Compared with RMT, it has been associated with less pain and better cosmetic outcomes.
An Outbreak of USA300 Methicillin-Resistant Staphylococcus aureus Among People With HIV in Japan
Authors: Ikeuchi Kazuhiko , Adachi Eisuke , Sasaki Takashi , Suzuki Masato , Lim Lay Ahyoung , Saito Makoto , Koga Michiko , Tsutsumi Takeya , Kido Yasutoshi , Uehara Yuki , Yotsuyanagi Hiroshi 
Published: October 2020

Abstract

Background
USA300 produces Panton-Valentin leucocidin (PVL) and is known as a predominant community-associated methicillin-resistant Staphylococcus aureus (MRSA) strain in the United States, but it was extremely rare in Japan. We report here an outbreak of USA300 in people with HIV (PWH) in Tokyo, Japan.

Methods
We analyzed the cases of PVL-MRSA infection between 2010 and 2020 and screened for nasal colonization of PVL-MRSA in PWH who visited an HIV/AIDS referral hospital from December 2019 to March 2020. Whole-genome sequencing-based single nucleotide polymorphism (SNP) analysis was performed on these isolates.

Results
During the study period, a total of 21 PVL-MRSA infections in 14 patients were identified after 2014. The carriage prevalence was 4.3% (12/277) and PVL-MRSA carriers were more likely to have sexually transmitted infections (STIs) within a year compared with patients who had neither a history of PVL-MRSA infection nor colonization (33.3% [4/12] vs 10.1% [26/258]; P = .03). SNP analysis showed that all 26 isolates were ST8-SCCmecIVa-USA300. Twenty-four isolates were closely related (≤100 SNP differences) and had the nonsynonymous SNPs associated with carbohydrate metabolism and antimicrobial tolerance.

Conclusions
An outbreak of USA300 has been occurring among PWH in Tokyo and a history of STI was a risk of colonization.
“I Want to Look Transgender”: Anti-Assimilation, Gender Self-Determination, and Confronting White Supremacy in the Creation of a Just Judaism
Authors: Crasnow S J 
Published: October 2020

AbstractIn this article, I consider transgender identity and white Jewish identity to argue that “passing” or normative assimilation is a trap, in that it extends the offer of privilege to individuals who can “successfully” conform within the confines of normativity, while leaving intact, or even reifying, the oppressive systems that are at work. As a corrective to normative assimilation, I consider alternative models for Jewish life offered by nonnormative Jewish communities that resist these oppressive norms. I further argue for the normativity and privileging of “passing” to be replaced with a non-hierarchical approach that lets all genders, all Jewish (and other) identities, be treated as valid or “real.”
Identification of Variants in Alpha-1-Antitrypsin by High Resolution Melting
Authors: Bidla Gawa , Rosenblatt David S , Gilfix Brian M 
Published: October 2020

Abstract

Background
Alpha-1-antitrypsin deficiency (AATD) is one of the most common hereditary disorders occurring in populations of European origin and is due to variants in SERPINA1, which encodes a protease inhibitor of neutrophil elastase, limiting lung damage from this enzyme. The World Health Organization has recommended that individuals with chronic obstructive pulmonary disease and asthma be tested for AATD. The development of inexpensive and simple genetic testing will help to meet this goal.

Methods
Primers and synthetic SERPINA1 gene fragments (gBlocks) were designed for 5 AATD-associated variants. PCR was run on a CFX96 Thermal Cycler with High Resolution Melting (HRM) capacity and data analyzed using the supplied HRM-analysis software. Genomic DNA from individuals (n = 86) genotyped for the S and Z variants were used for validation. HRM-analysis was performed on 3 additional samples with low alpha-1-antitrypsin levels inconsistent with the genotype determined in our clinical laboratory.

Results
Unique normalized melt curve and difference curve patterns were identified for the AAT variants Z, S, I, F, and MMalton using gBlocks. Similar curve shapes were seen when these primers were used to analyze the gDNA samples. HRM identified the genotypes of the gDNA correctly with 100% concordance. The curve shapes of some samples did not match the melting patterns of the targeted variant. Sequencing was used to identify the variants, including rare AATD variants c.1108_1115delinsAAAAACA (p.Glu370Lysfs*31) and c.1130dup (p.Leu377fs).

Conclusion
We developed a rapid and inexpensive HRM-analysis method for genotyping of Z, S, MMalton, I, and F variants that was also capable of detecting other variants.
Rapid Detection of Adulteration in Dendrobium huoshanense Using NIR Spectroscopy Coupled with Chemometric Methods
Authors: Hao Jing-Wen , Chen Yue , Chen Nai-Dong , Qin Chao-Feng 
Published: October 2020

Abstract

Background
Dendrobium huoshanense (DHS) is a typical traditional Chinese medicine with unique medical and high economic values; however, it may easily be adulterated with cheaper alternatives (e.g. Dendrobium henanese, DHN), because of their similar appearances and tastes.

Objective
In this study, adulteration of DHN in DHS was detected by near infrared (NIR) spectroscopy combined with chemometric methods.

Methods
By performing partial least squares (PLS) analysis, PLS multivariate methods including partial least-squares discriminant analysis (PLS-DA), and partial least-squares regressions (PLSR) were applied to the obtained spectral data to build models. The PLS-DA model was employed to differentiate between pure DHS samples and those adulterated with DHN.

Results
The R2 value obtained for the PLS-DA model was 0.4898 with an RMSEP error of 0.1554, resulting in a 100% accuracy of validation sample sets. Similarly, a PLSR model was also developed to quantify the amount of DHN adulterant in DHS samples. Experimental results indicated that the good performance of the multiplicative scattering correction (MSC) model is the better model showing a prediction performance of RMSEP of 2.38 and R2 of 0.9946.

Conclusions
These results suggest that the combination of NIR spectroscopy and chemometric method provides a fast, simple and reliable method for detecting adulteration of DHS.

Highlights
The method of classification allowed identification of both authentic and adulterated DHS samples. Comparison of six different techniques for spectra preprocessing to improve quantitative model performance was obtained with MSC derivative spectra. The method can detect most of the current DHS adulterations in the Chinese market.
Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted fromPichia pastoris
Authors: Nakamura Hitomi , Kiyoshi Masato , Anraku Makoto , Hashii Noritaka , Oda-Ueda Naoko , Ueda Tadashi , Ohkuri Takatoshi 
Published: October 2020

AbstractGlycoengineering of therapeutic proteins has been applied to improve the clinical efficacy of several therapeutics. Here, we examined the effect of glycosylation on the properties of the Fab of the therapeutic antibody, adalimumab. An N-glycosylation site was introduced at position 178 of the H chain constant region of adalimumab Fab through site-directed mutagenesis (H:L178N Fab), and the H:L178N Fab was produced in Pichia pastoris. Expressed mutant Fab contained long and short glycan chains (L-glyco Fab and S-glyco Fab, respectively). Under the condition of aggregation of Fab upon pH shift-induced stress, both of L-glyco Fab and S-glyco Fab were less prone to aggregation, with L-glyco Fab suppressing aggregation more effectively than the S-glyco Fab. Moreover, the comparison of the antigenicity of glycosylated and wild-type Fabs in mice revealed that glycosylation resulted in the suppression of antigenicity. Analysis of the pharmacokinetic behaviour of the Fab, L-glyco Fab and S-glyco Fab indicated that the half-lives of glycosylated Fabs in the rats were shorter than that of wild-type Fab, with L-glyco Fab having a shorter half-life than S-glyco Fab. Thus, we demonstrated that the glycan chain influences Fab aggregation and immunogenicity, and glycosylation reduces the elimination half-life in vivo.
The Impact of No Next of Kin Decision Makers on End-of-Life Care
Authors: Ota Ryan K , Johnson Maxwell B , Pickering Trevor A , Garner Warren L , Gillenwater T Justin , Yenikomshian Haig A 
Published: October 2020

AbstractFor critically ill burn patients without a next of kin, the medical team is tasked with becoming the surrogate decision maker. This poses ethical and legal challenges for burn providers. Despite this frequent problem, there has been no investigation of how the presence of a next of kin affects treatment in burn patients. To evaluate this relationship, a retrospective chart review was performed on a cohort of patients who died during the acute phase of their burn care. Variables collected included age, gender, length of stay, total body surface area, course of treatment, and presence of a next of kin. In total, 67 patients met the inclusion criteria. Of these patients, 14 (21%) did not have a next of kin involved in medical decisions. Patients without a next of kin were significantly younger (P = .02), more likely to be homeless (P &lt; .01), had higher total body surface area burns (P = .008), had shorter length of stay (P &lt; .001), and were five times less likely to receive comfort care (P = .01). Differences in gender and ethnicity were not statistically significant. We report that patients without a next of kin present to participate in medical decisions are transitioned to comfort care less often despite having a higher burden of injury. This disparity in standard of care demonstrates a need for a cultural shift in burn care to prevent the suffering of these marginalized patients. Burn providers should be empowered to reduce suffering when no decision maker is present.
Molecular and Morphological Identification of Trichogramma (Hymenoptera: Trichogrammatidae) Species From Asian Corn Borer (Lepidoptera: Crambidae) in Myanmar
Authors: Myint Yee Yee , Bai Shuxiong , Zhang Tiantao , Babendreier Dirk , He Kanglai , Wang Zhenying 
Published: October 2020

Abstract
The Asian corn borer, Ostrinia furnacalis (Guenée), is the most devastating maize pest in Myanmar. The damage caused by this pest has become a significant obstacle to farmers’ income and the national economy. Control of O. furnacalis is challenging due to its protected feeding sites and the crop’s height during later phases of the pest’s attack. Trichogramma (Hymenoptera: Trichogrammatidae) parasitoids have been used successfully against corn borers in other countries, but knowledge on the species composition in Myanmar is limited. As a first step for potential biological control of Asian corn borer in Myanmar, Trichogramma were collected from major maize growing regions. Identification was performed based on both morphological and molecular techniques. The majority of collected specimens were identified as Trichogramma ostriniae Pang and Chen, T. chilonis Ishii, and T. dendrolimi Matsumura. This is the first report on the composition of Trichogramma species, and an important step towards the establishment of biological control against O. furnacalis in Myanmar.
A towed-type shallow high-resolution seismic detection system for coastal tidal flats and its application in Eastern China
Authors: Yue Hangyu , Zhang Baowei , Wang Kai , Wang Dayong , Wang Guangke , Wang Xiaojiang , Zhang Kai , Li Jinli 
Published: October 2020

Abstract
Restricted by detective equipment and tidal influence seriously, coastal tidal flats are often treated as the transition belt of paralic zone in terms of seismic detection, causing low exploration degree and accuracy in these areas. What is worse, conventional shallow seismic method has a complex system and low acquisition efficiency, which cannot meet the requirements for high-efficiency acquisition in tidal flats. To solve these problems, a towed shallow seismic detection system is specially established for coastal tidal areas, mainly including electric spark source and towable ship-type geophone strings. After comparisons, some advantages of this method are obtained, such as high efficiency, low cost and reliability. Furthermore, its detective accuracy and depth can reach the meter level and more than 800 m, respectively. Then, a series of shallow seismic processing methods are improved for coastal tidal flats. Deconvolution and velocity analysis are emphatically introduced to multiple-wave attenuation. A short array of this towable detection can keep a far more effective wave from being cut off because of its small NMO stretch. Last but not least, the towable method in coastal tidal-flat zones can successfully identify the stratigraphic structure, interface, palaeo-channel, concealed active fault and submarine shallow gas in Jiangsu Coast, Eastern China, which has great practical results and significance for geological and environmental surveys, as well as scientific geo-hazard prevention and mitigation in these areas.
Autologous matrix-induced chondrogenesis and bone marrow aspirate concentrate compared with microfracture for arthroscopic treatment of femoroacetabular impingement and chondral lesions of the hip: bridging the osteoarthritis gap and facilitating enhanced recovery
Authors: Sobti Anshul S , Baryeh Kwaku W , Woolf Rex , Chana Rishi 
Published: October 2020

Abstract
In an attempt to bridge the osteoarthritis (OA) gap, this study compared biological reconstruction with traditional microfracture (MF) techniques in patients with femoroacetabular impingement and focal cartilage defects. Cohorts of two groups were investigated; age, gender and Tonnis grade matched comparison for outcomes between MF and newer biological reconstruction techniques hip arthroscopy surgery using autologous matrix-induced chondrogenesis and bone marrow aspirate combination. Outcomes investigated were pre-op and post-op mean iHOT-12 scores up to 18 months after surgery with a Kaplan–Meier survivorship analysis. Of 111 patients, 46 patients underwent MF and 65 biological reconstruction hip arthroscopy including cam/pincer osteoplasty and labral repair surgery. Age range was 20–69, mean age 45 years for both groups, Tonnis grading was as follows: Grade 0: 26% versus 30%, Grade 1: 52% versus 47% and Grade 2: 22% versus 23% in MF and biological reconstruction groups, respectively. The mean post-operative iHOT-12 score differences between MF and biological reconstruction were significant at 1-year minimum follow-up (P = 0.01, SD 2.8). Biological reconstruction allowed for an enhanced recovery protocol. The MF group had a 67.4% survivorship for conversion to hip replacement at 18 months (32.6% failure rate for any reason) and biological reconstruction had 100% survivorship at 18 months post-operatively with no failures for any reason. This study provides further support to the evidence base for biological reconstructive techniques as superior to MF in combination with joint preservation arthroscopic surgery, even in the face of focal cartilage defects and offers both surgeons and patients a potential bridging of the OA gap.
A management of neutropenia using granulocyte colony stimulating factor support for chemotherapy consisted of docetaxel, cisplatin and 5-fluorouracil in patients with oesophageal squamous cell carcinoma
Authors: Katada Chikatoshi , Sugawara Mitsuhiro , Hara Hiroki , Fujii Hirofumi , Nakajima Takako Eguchi , Ando Takayuki , Kojima Takashi , Watanabe Akinori , Sakamoto Yasutoshi , Ishikawa Hideki , Hosokawa Ayumu , Hamamoto Yasuo , Muto Manabu , Tahara Makoto , Koizumi Wasaburo 
Published: October 2020

Abstract

Background
An exploratory study was designed to evaluate the efficacy of granulocyte colony stimulating factor support for chemotherapy consisting of docetaxel, cisplatin and 5-fluorouracil chemotherapy in patients with oesophageal cancer.

Methods
The inclusion criteria were as follows: (1) oesophageal squamous cell carcinoma, (2) a schedule to receive three courses of induction chemotherapy (docetaxel 75 mg/m2 day 1, cisplatin 75 mg/m2 day 1, 5-fluorouracil 750 mg/m2 days 1–5, every 3 weeks), (3) stage IB-III, (4) 20–75 years old, (5) 0–1 performance status, (6) preserved organ functions and (7) written informed consent. The endpoints were to evaluate the efficacy of granulocyte colony stimulating factor support including secondary prophylactic usage for docetaxel, cisplatin and 5-fluorouracil chemotherapy. Patients who previously had ‘febrile neutropenia’, or ‘Grade 3 or 4 infection accompanied by grade 3 or 4 neutropenia’ prophylactically received granulocyte colony stimulating factor support from day 7.

Results
A total of 91 patients were included in the analysis. Granulocyte colony stimulating factor support was given to 81.3%. The incidence of grade 4 neutropenia and febrile neutropenia were 81.3 and 32.9%, respectively. The dose of anticancer agents was reduced in 48.4%. There were no treatment-related deaths. The relative dose intensity of docetaxel, cisplatin and 5-fluorouracil were 92.7 ± 9.8%, 86.0 ± 15.6% and 91.8 ± 10.0%, respectively. In the secondary prophylactic granulocyte colony stimulating factor support group, the neutrophil count significantly increased between day 7 and day 13 as compared with the non-prophylactic granulocyte colony stimulating factor support group (P &lt; 0.05 for each day).

Conclusions
Granulocyte colony stimulating factor support including secondary prophylactic usage may be feasible for maintaining the intensity of docetaxel, cisplatin and 5-fluorouracil chemotherapy in patients with oesophageal cancer.
Electoral Systems, Selection, and Re-election: Evidence from Italian Municipalities
Authors: Gulino Giorgio 
Published: October 2020

Abstract
Using micro-level data on local Italian elections and exploiting a discontinuity at a population cutoff, I study the effect of electoral systems on politician selection and re-election. Evidence shows that the mayor’s probability of re-election is 25 percentage points higher in majoritarian systems than in proportional systems. Ruling coalitions elected under the majoritarian system enjoy a stable and long-lasting majority, attract more central transfers, and invest more in public libraries. While mayors elected under the two different electoral systems do not differ in any observable characteristics, they do tend to embark on a different political careers once they lose their municipal office. Surprisingly, mayors elected under the proportional system have a higher probability of being elected to regional offices after their mandate. (JEL D72, H70, P16)