bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis
Authors: De Queiroz Andrade Ediane , Da Silva Sena Carla Rebeca , Collison Adam , Murphy Vanessa E , Gould Gillian Sandra , Bonevski Billie , Mattes Joerg 
Published: September 2020

ObjectiveTo evaluate what is known about active tobacco use during pregnancy and the association with infant respiratory health.DesignSystematic review and meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesMEDLINE, EMBASE, Cochrane, CINAHL, and Maternity and Infant Care were searched thoroughly until June 2020.Eligibility criteria for selecting studiesWe included case–control and cohort studies estimating the association between active tobacco use during pregnancy and infant respiratory health (wheezing and apnoea) and lung function parameters in the first 12 months of life.Data extraction and synthesisExtraction and risk of bias assessment were conducted by two independent reviewers. The odds ratio, relative risk and mean differences were pooled with a 95% CI using the generic inverse variance method. Heterogeneity was assessed and expressed by percentage using I2.ResultsWe identified 4423 abstracts, and 21 publications met the eligibility criteria. Pooled OR showed an increase in wheezing episodes in infants born to mothers who were active tobacco users during pregnancy (OR 1.50, 95% CI 1.27 to 1.77, p<0.01). Mixed results were found on lung function parameters, and a meta-analysis including two studies with comparable methodology showed a trend towards reduced maximum flow rate at functional residual capacity of −34.59 mL/s (95% CI −72.81 to 3.63, p=0.08) in 1-month-old infants born to women who smoked during pregnancy. A higher risk of apnoea was described for infants born to mothers who used smokeless tobacco during pregnancy, while the results in infants born to women who actively smoked tobacco during pregnancy were non-conclusive.ConclusionInfants born to mothers who actively smoked during pregnancy are at higher odds of having wheeze and may have lower lung function. Smokeless tobacco use in pregnancy may increase the risk of apnoea in infancy.PROSPERO registration numberCRD42018083936.
Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial
Authors: Hüttner Felix J , Rooman Ilse , Bouche Gauthier , Knebel Phillip , Hüsing Johannes , Mihaljevic André L , Hackert Thilo , Strobel Oliver , Büchler Markus W , Diener Markus K 
Published: September 2020

IntroductionPancreatic cancer is the fourth-leading cause of cancer-related death in developed countries. Despite advances in systemic chemotherapy, the mainstay of curative therapy for non-metastatic disease is surgical resection. However, the perioperative period is characterised by stress and inflammatory reactions that can contribute to metastatic spread and disease recurrence. Catecholamines and prostaglandins play a crucial role in these reactions. Therefore, a drug repurposing of betablockers and cyclooxygenase inhibitors seems reasonable to attenuate tumour-associated inflammation by inhibiting psychological, surgical and inflammatory stress responses. This may cause a relevant antitumourigenic and antimetastatic effect during the perioperative period, a window for cancer-directed therapy that is currently largely unexploited.Methods and analysisThis is a prospective, single-centre, two-arm randomised, patient and observer blinded, placebo-controlled, phase-II trial evaluating safety and feasibility of combined perioperative treatment with propranolol and etodolac in adult patients with non-metastatic cancer of the pancreatic head undergoing elective pancreatoduodenectomy. 100 patients fulfilling the eligibility criteria will be randomised to perioperative treatment for 25 days perioperatively with a combination of propranolol and etodolac or placebo. Primary outcome of interest will be safety in terms of serious adverse events and reactions within 3 months. Furthermore, adherence to trial medication will be assessed as feasibility outcomes. Preliminary efficacy data will be evaluated for the purpose of power calculation for a potential subsequent phase-III trial. The clinical trial is accompanied by a translational study investigating the mechanisms of action of the combined therapy on a molecular basis.Ethics and disseminationThe PROSPER-trial has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4042875) and the Ethics Committee of the Medical Faculty of the University of Heidelberg (reference number AFmo-385/2018). The final trial results will be published in a peer-reviewed journal and will be presented at appropriate national and international conferences.Trial registration numbersDRKS00014054; EudraCT number: 2018-000415-25.
Addressing the high-f problem in pseudo-Nambu–Goldstone boson dark energy models with dark matter–dark energy interaction
Authors: Mukhopadhyay Upala , Paul Avik , Majumdar Debasish 
Published: September 2020

AbstractWe consider a dark energy scenario driven by a scalar field $$\phi $$
ϕ
with a pseudo-Nambu–Goldstone boson (pNGB) type potential $$V(\phi )=\mu ^4 \left( 1+ \mathrm{cos}(\phi /f) \right) $$

V

(
ϕ
)

=

μ
4

1
+
cos
(
ϕ
/
f
)

. The pNGB originates out of breaking of spontaneous symmetry at a scale f close to Planck mass $$M_\mathrm{{pl}}$$

M
pl

. We consider two cases namely the quintessence dark energy model with pNGB potential and the other, where the standard pNGB action is modified by the terms related to Slotheon cosmology. We demonstrate that for this pNGB potential, high-f problem is better addressed when the interaction between dark matter and dark energy is taken into account and that Slotheon dark energy scenario works even better over quintessence in this respect. To this end, a mass limit for dark matter is also estimated.
Fermi motion and medium effects on reaction cross sections of 13,14,15B + C, Al at intermediate and high energies
Authors: Rashdan M. , Abdel-Karim T. A. 
Published: September 2020

Analysis of reaction cross sections of [Formula: see text] are performed with Glauber model (GM) including medium modifications arising from Fermi motion and in-medium nucleon–nucleon (NN) total reaction cross section. The density distributions of Boron isotopes are described by a deformed-average Fermi shape, whose proton and neutron radii and deformation parameters are derived from relativistic mean field (RMF), harmonic oscillator (HO) and two-parameter Fermi (2pF). These densities can describe the reaction cross section of Boron isotopes except for [Formula: see text] which is better described by an HO core plus extended Gaussian (HOG) or HO plus a modified Yukawa (HOMY) tail, which depends on the 1n separation energy. It is found that Fermi motion effects dominated at intermediate energy, and they are important to describe the data in addition to in-medium effects. In-medium effects, which are incorporated locally, reduced the reaction cross section by about 3–5% at all energies. [Formula: see text] is confirmed as a one-neutron halo nucleus, where a large extended tail is observed in the extracted HOMY and HOG model densities as well as in the extracted radii, where the matter radius of [Formula: see text] is found to be about 2.92 fm, which is larger than that of [Formula: see text] (2.5 fm) and [Formula: see text] (2.82 fm) predicted using the GM model including Fermi motion and in-medium effects.
Computing Autotopism Groups of Partial Latin Rectangles
Authors: Stones Rebecca J. , Falcón Raúl M. , Kotlar Daniel , Marbach Trent G. 
Published: September 2020

Computing the autotopism group of a partial Latin rectangle (PLR) can be performed in multiple ways. This study has two aims: comparing some of these methods experimentally to identify those that are competitive; and identifying design goals for developing practical software. We compare six families of algorithms (two backtracking and four graph-theoretic methods), with and without using entry invariants (EIs), in a range of settings. Two EIs are considered: frequencies of row, column, and symbol representatives; and 2 × 2 submatrices. The best approach to computing autotopism groups varies.
When PLRs have many autotopisms (such as having very few entries or being a group table), the McKay, Meynert, and Myrvold (MMM) method computes generators for the autotopism group efficiently. (The MMM method is the standard way to compute autotopisms.) Otherwise, PLRs ordinarily have trivial or small autotopism groups, and the task is to verify this. The so-called PLR graph method is slightly more efficient in this setting than the MMM method (in some circumstances, around twice as fast).
With an intermediate number of entries, the quick-to-compute strong EIs are effective at reducing the need for computation without introducing significant overhead. With a full or almost-full PLR, a more sophisticated EI is needed to reduce down-the-line computation.
These results suggest a hybrid approach to computing autotopism groups: The software decides on suitable EIs based on the input; and the user chooses between the MMM or the PLR graph methods, depending on their dataset.

This article expands the authors’ previous article
Computing autotopism groups of PLRs: a pilot study
.
Effectiveness of the Healthy Lifestyle Promotion Program for Yaquis with Obesity and Risk of Diabetes in the Short and Medium Term: A Translational Study
Authors: Castro-Juarez Alejandro Arturo , Serna-Gutiérrez Araceli , Dórame-López Norma Alicia , Solano-Morales Mariela , Gallegos-Aguilar Ana Cristina , Díaz-Zavala Rolando Giovanni , Alemán-Mateo Heliodoro , Urquidez-Romero Rene , Campa-Quijada Fernanda , Valenzuela-Guzmán Diana Marcela , Esparza-Romero Julián , Cardoso Claudia 
Published: September 2020

Type 2 diabetes (T2D) is a public health problem worldwide, and the main risk factor for its development is obesity. The Yaqui ethnic group of Sonora has serious obesity problems, resulting in an increased risk of T2D in its inhabitants. The objective of this study was to evaluate the effectiveness of a health promotion program on obesity parameters and cardiovascular risk factors in short- (6 months) and medium-term periods (12 months) in indigenous Yaquis of Sonora. The design is a translational clinical study of a single cohort with prepost intervention measurements in a sample of 93 subjects. The effectiveness of the program was evaluated by comparing obesity parameters, metabolic markers, and physical activity 6 and 12 months with those measured under basal conditions using a paired

t

-test or Wilcoxon rank-sum test. The short-term retention percentage was 58.0%. There was a decrease in body weight (

Δ
=
−
3.9

kg

,

p
≤
0.05

) and other obesity parameters, and an increase in physical activity and improvements in metabolic markers (

p
≤
0.05

) was observed. Similar findings were obtained for the medium-term period; body weight loss was also -3.9 kg (

p
≤
0.05

). The short and medium-term results of the program showed improvements in the obesity parameters and other cardiovascular risk factors of the participants. These results support the effectiveness of the program and its translation in this ethnic group.
Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Authors: Tamura Naoka , Shaikh Nadeem , Muliaditan Daniel , Soliman Tanya N. , McGuinness Jennifer R. , Maniati Eleni , Moralli Daniela , Durin Mary-Anne , Green Catherine M. , Balkwill Frances R. , Wang Jun , Curtius Kit , McClelland Sarah E. 
Published: September 2020

AbstractChromosomal instability (CIN) comprises continual gain and loss of chromosomes or parts of chromosomes and occurs in the majority of cancers, often conferring poor prognosis. Because of a scarcity of functional studies and poor understanding of how genetic or gene expression landscapes connect to specific CIN mechanisms, causes of CIN in most cancer types remain unknown. High-grade serous ovarian carcinoma (HGSC), the most common subtype of ovarian cancer, is the major cause of death due to gynecologic malignancy in the Western world, with chemotherapy resistance developing in almost all patients. HGSC exhibits high rates of chromosomal aberrations and knowledge of causative mechanisms would represent an important step toward combating this disease. Here we perform the first in-depth functional characterization of mechanisms driving CIN in HGSC in seven cell lines that accurately recapitulate HGSC genetics. Multiple mechanisms coexisted to drive CIN in HGSC, including elevated microtubule dynamics and DNA replication stress that can be partially rescued to reduce CIN by low doses of paclitaxel and nucleoside supplementation, respectively. Distinct CIN mechanisms indicated relationships with HGSC-relevant therapy including PARP inhibition and microtubule-targeting agents. Comprehensive genomic and transcriptomic profiling revealed deregulation of various genes involved in genome stability but were not directly predictive of specific CIN mechanisms, underscoring the importance of functional characterization to identify causes of CIN. Overall, we show that HGSC CIN is complex and suggest that specific CIN mechanisms could be used as functional biomarkers to indicate appropriate therapy.Significance:These findings characterize multiple deregulated mechanisms of genome stability that lead to CIN in ovarian cancer and demonstrate the benefit of integrating analysis of said mechanisms into predictions of therapy response.
Measuring Driver Perception: Combining Eye-Tracking and Automated Road Scene Perception
Authors: Stapel Jork , El Hassnaoui Mounir , Happee Riender 
Published: September 2020

Objective To investigate how well gaze behavior can indicate driver awareness of individual road users when related to the vehicle’s road scene perception. Background An appropriate method is required to identify how driver gaze reveals awareness of other road users. Method We developed a recognition-based method for labeling of driver situation awareness (SA) in a vehicle with road-scene perception and eye tracking. Thirteen drivers performed 91 left turns on complex urban intersections and identified images of encountered road users among distractor images. Results Drivers fixated within 2° for 72.8% of relevant and 27.8% of irrelevant road users and were able to recognize 36.1% of the relevant and 19.4% of irrelevant road users one min after leaving the intersection. Gaze behavior could predict road user relevance but not the outcome of the recognition task. Unexpectedly, 18% of road users observed beyond 10° were recognized. Conclusions Despite suboptimal psychometric properties leading to low recognition rates, our recognition task could identify awareness of individual road users during left turn maneuvers. Perception occurred at gaze angles well beyond 2°, which means that fixation locations are insufficient for awareness monitoring. Application Findings can be used in driver attention and awareness modelling, and design of gaze-based driver support systems.
Hsa_circ_0003829 serves as a potential diagnostic predictor for oral squamous cell carcinoma
Authors: Zhang Hanyu , Shen Yuehong , Zhang Biru , Qian Min , Zhang Ying , Yang Hongyu 
Published: September 2020

Objective Increasing evidence suggests that circular RNAs (circRNAs) play a major role in tumorigenesis and cancer progression. This study aimed to identify aberrant expression of hsa_circ_0003829 in oral squamous cell carcinoma (OSCC) and to explore its clinical significance. Methods We conducted a prospective clinical study to examine the expression pattern of hsa_circ_0003829 in 60 paired OSCC and normal clinical samples and in cell lines using real-time quantitative polymerase chain reaction. We also evaluated the diagnostic value of hsa_circ_0003829 in OSCC based on receiver operating characteristic (ROC) curve analysis, and examined the relationships between hsa_circ_0003829 expression and clinicopathological features in patients with OSCC. We further used bioinformatics software CircInteractome ( https: //Circinteractome.nia.nih.gov/ ) to predict circRNA–microRNA interactions. Results Hsa_circ_0003829 was significantly downregulated in OSCC compared with adjacent normal tissues. The area under the ROC curve was 0.81. Low expression levels of hsa_circ_0003829 in OSCC tissues were negatively correlated with lymph node metastasis status and TNM stage. Conclusions Downregulated expression of has_circ_0003829 suggests that this may be a key circRNA in OSCC, and may serve as a prospective biomarker for the diagnosis of OSCC.
Finger orthoses for management of joint hypermobility disorders: Relative effects on hand function and cognitive load
Authors: Jensen Anne-Mette , Andersen Joan Quist , Quisth Lena , Ramstrand Nerrolyn 
Published: September 2020

Background:
Joint hypermobility refers to joints that move beyond their normal limits. Individuals with hypermobility of the fingers experience difficulties in activities of daily living. Finger orthoses are available for managing hypermobility of the fingers, but their effectiveness has received little attention in scholarly literature.

Objectives:
To determine if use of custom fit finger orthoses leads to improvements in time needed to perform standardised hand function tests, and attentional demand required to perform these tests, in individuals with joint hypermobility syndrome, Hypermobile Ehlers-Danlos syndrome or Classical Ehlers-Danlos syndrome.

Study design:
Repeated-measures study.

Methods:
Fourteen participants performed three different hand function tests (target box and block test, writing and picking up coins), with and without their finger orthoses. Time to complete each test was recorded as a measure of functional performance. Brain activity was recorded in the pre-frontal cortices as a measure of attentional demand.

Results:
Functional performance significantly improved for all but one test (picking up coins with non-dominant hand) when participants wore finger orthoses (p < 0.05). Activity in the pre-frontal cortex was lower when using the orthosis to perform the coin test (dominant hand; p < 0.05). No differences were observed in other tests (p > 0.05).

Conclusions:
Results suggested that finger orthoses improved hand function and provided limited evidence to suggest that they may also affect attentional demand. While the limited sample does not provide conclusive evidence supporting the use of finger orthosis in this clinical population, results warrant further investigation in large scale longitudinal studies or randomised controlled trials.
The Association of Social Support and Leisure Time Physical Activity With Mental Health Among Individuals With Cancer
Authors: Kim Jaehyun , Kim Junhyoung , Williams Ronald D. , Han Areum 
Published: September 2020

Purpose: This study examined the relationship among social support, leisure time physical activity (LTPA), and mental health among people with cancer. Design: Cross-sectional study. Setting and participants: Using the 2017 Health Information National Trends Survey, we extracted data of 504 respondents who had been diagnosed with any of the 22 types of cancer listed in the survey questionnaire. Measures: As independent variables, we assessed 3 different types of support: emotional, informational, and tangible support. As mediating and outcome variables, we measured LTPA and mental health, respectively. Analysis: Using AMOS version 22, a path analysis was conducted to measure model fit. A mediation test was then conducted using bootstrapping procedures. Results: The hypothesized model provided an acceptable fit to the data. Specifically, emotional support ( b = .15, p = .005), informational support ( b = .13, p = .008), tangible support ( b = .12, p = .010), and LTPA ( b = .14, p = .001) were significantly associated with mental health. We revealed a significant mediating effect of LPTA on the relationship between emotional support and mental health (Estimate = .037, 95% CI = .001–.098, p < .05). Conclusion: Social support and LTPA played a significant role in promoting mental health among people with cancer. In particular, the results confirmed that individuals with cancer who reported receiving emotional support tended to engage in LTPA and thus reported better mental health.
Feasibility of the Hand in Hand Relationship Intervention for Stroke Survivor–Caregiver Dyads: A Randomized Trial
Authors: McCarthy Michael J. , Sanchez Angelica , Garcia Y. Evie , Lyons Karen S. , Bakas Tamilyn 
Published: September 2020

Purpose: A strong interpersonal relationship after stroke is important for the prevention of depression in survivors and family caregivers. This study aimed to test the feasibility of quality of relationship intervention for stroke dyads called Hand in Hand (HiH). Methods: Sixteen dyads were randomized into either the HiH group ( n = 8) or information, support, and referral (ISR) control group ( n = 8). HiH dyads received up to eight sessions, with topics prioritized according to a 17-item screening tool. ISR dyads received up to eight sessions that included information, active listening, and referrals. Feasibility, acceptability, and outcomes data were collected for both groups. Results: The HiH and ISR groups were feasible and acceptable. Caregivers in both groups, as well as survivors in the ISR group, experienced improvements in depressive symptoms and other select outcomes. Conclusions: Findings suggest that HiH is feasible to implement with stroke dyads and that it merits further refinement and testing.
Enhancing patients’ understanding of and adherence to oral anticancer medication: Results of a longitudinal pilot intervention
Authors: Lin Mingqian , Hackenyos Douglas , Savidge Nicole , Weidner Ruth Ann , Murphy-Banks Rachel , Fleckner Tara , Parsons Susan K , Rodday Angie Mae 
Published: September 2020

Background Oral anticancer medications (OAM) make administration more convenient for patients, but shifts the responsibility of care from clinical providers to the patients themselves. Following an institutional pilot study showing inadequate understanding and adherence among vulnerable patients taking OAM, a longitudinal intervention was developed using an oncology specialty pharmacist and medication navigators to enhance OAM understanding and adherence. Methods Patients initiating OAM were approached for four formalized teaching and check-in sessions, supplemented with medication information sheets and individualized calendars. At each session, participants were assessed on their OAM understanding and adherence using teach-back and validated measures. A study evaluation elicited feedback from participants on the usefulness of the intervention. Results Of 80 eligible patients, 58 (72.5%) received formal OAM teaching from the specialty pharmacist. Of those, 54 (93.1%) enrolled in the study with 39 (72%) completing the intervention for final analysis. At study completion, all participants adequately understood OAM taking, but 41.0% had inadequate understanding of OAM handling. Throughout the study, participants reported issues that were addressed by the intervention team (28.2% to 31.6%) as well as those requiring additional assistance from the treatment team (26.3% to 38.5%), Most participants found the intervention to be very beneficial (initial evaluation, 86.5%; final evaluation, 76.9%). Conclusions This pilot intervention addressed gaps identified by our institutional assessment through formalized OAM teaching and follow-up. Improved understanding of taking and handling OAM through this subsequent study illustrated the enhanced effect of a multidisciplinary and multicomponent intervention to better educate and support patients on OAM.