bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoplasmic reticulum Ca2+ release causes Rieske iron–sulfur protein-mediated mitochondrial ROS generation in pulmonary artery smooth muscle cells
Authors: Dong Dapeng , Hao Qiongyu , Zhang Ping , Wang Tao , Han Fei , Liang Xiaodong , Fei Zhenghua 
Published: November 2019

Abstract
Mitochondrial reactive oxygen species (ROS) cause Ca2+ release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role in hypoxic pulmonary vasoconstriction (HPV). Here we tested a novel hypothesis that hypoxia-induced RyR-mediated Ca2+ release may, in turn, promote mitochondrial ROS generation contributing to hypoxic cellular responses in PASMCs. Our data reveal that application of caffeine to elevate intracellular Ca2+ concentration ([Ca2+]i) by activating RyRs results in a significant increase in ROS production in cytosol and mitochondria of PASMCs. Norepinephrine to increase [Ca2+]i due to the opening of inositol 1,4,5-triphosphate receptors (IP3Rs) produces similar effects. Exogenous Ca2+ significantly increases mitochondrial-derived ROS generation as well. Ru360 also inhibits the hypoxic ROS production. The RyR antagonist tetracaine or RyR2 gene knockout (KO) suppresses hypoxia-induced responses as well. Inhibition of mitochondrial Ca2+ uptake with Ru360 eliminates N- and Ca2+-induced responses. RISP KD abolishes the hypoxia-induced ROS production in mitochondria of PASMCs. Rieske iron–sulfur protein (RISP) gene knockdown (KD) blocks caffeine- or NE-induced ROS production. Taken together, these findings have further demonstrated that ER Ca2+ release causes mitochondrial Ca2+ uptake and RISP-mediated ROS production; this novel local ER/mitochondrion communication-elicited, Ca2+-mediated, RISP-dependent ROS production may play a significant role in hypoxic cellular responses in PASMCs.
Comprehensive assessment of the association between XPC rs2228000 and cancer susceptibility based on 26835 cancer cases and 37069 controls
Authors: Dai Yingqi , Song Zhonghua , Zhang Jinqing , Gao Wei 
Published: November 2019

Abstract
Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer.
Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P-value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated.
Results We selected a total of 71 eligible studies with 26835 cancer cases and 37069 controls from the 1186 retrieved articles. There is an enhanced susceptibility for bladder cancer cases under T vs. C [P=0.004; OR (95% CI) = 1.25 (1.07, 1.45)], TT vs. CC [P=0.001; 1.68 (1.25, 2.26)], CT+TT vs. CC [P=0.016; 1.26 (1.04, 1.53)], and TT vs. CC+ CT [P=0.001; 1.49 (1.18, 1.90)] compared with negative controls. Additionally, there is an increased risk of breast cancer under T vs. C, TT vs. CC and TT vs. CC+ CT (P&lt;0.05, OR &gt; 1). Nevertheless, there is a decreased risk of gastric cancer cases in China under T vs. C [P=0.020; 0.92 (0.85, 0.99)], CT vs. CC [P=0.001, 0.83 (0.73, 0.93)], and CT+TT vs. CC [P=0.003, 0.84 (0.76, 0.94)].
Conclusions The TT genotype of XPC rs2228000 may be linked to an increased risk of bladder and breast cancer, whereas the CT genotype is likely to be associated with reduced susceptibility to gastric cancer in the Chinese population.
Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms
Authors: Ji Yong-Zhi , Liu Shi-Rui 
Published: November 2019

AbstractKoebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.
Laparoskopische Hemihepatektomie links mit intraoperativer Indocyaningrün-Perfusionsbildgebung
Authors: Sucher Robert , Rademacher Sebastian , Lederer Andri , Hau Hans-Michael , Petersen Tim Ole , Seehofer Daniel 
Published: November 2019

ZusammenfassungDie intraoperative Indocyaningrün-Perfusionsbildgebung (ICG-Perfusionsbildgebung) ermöglicht eine genaue Identifikation von Lebersegmenten und Resektionsebenen, welche für die anatomische Leberresektion von Bedeutung sind. Wir berichten über einen 54-jährigen Patienten, bei dem aufgrund von rezidivierenden Cholangitiden bei Caroli-Erkrankung eine laparoskopische Hemihepatektomie links durchgeführt wurde. Zur Identifikation der exakten anatomischen Resektionslinie wurde dem Patienten nach Klemmen der linken Leberarterie und des linken Pfortaderastes intravenös ICG verabfolgt. Während der Parenchymdurchtrennung wurde die Leber im Normalweißlicht und Nahinfrarotlicht (NIR) untersucht. Diese Technik ermöglichte eine präzise anatomische Resektion der nicht perfundierten Lebersegmente 2, 3 und 4.
Lower GI Bleeding: An Update on Incidences and Causes
Authors: Adegboyega Titilayo , Rivadeneira David 
Published: November 2019

AbstractBleeding from the lower gastrointestinal tract represents a significant source of morbidity and mortality. The colon represents the vast majority of the location of bleeding with only a much smaller incidence occurring in the small intestine. The major causes of lower gastrointestinal bleeding (LGIB) are from diverticulosis, vascular malformations, and cancer. We discuss the incidence and causes of LGIB.
Investigation on dry machining of stainless steel 316 using textured tungsten carbide tools
Authors: Mashinini P M , Soni Hargovind , Gupta Kapil 
Published: November 2019

Abstract
In this research, austenitic stainless steel SS316 material has been machined using textured carbide cutting tools under dry conditions. Micro-textures were made on tool rake face using wire spark erosion machining technology. Effects of three important machining process parameters i.e. cutting speed, depth of cut and feed rate on machinability (MRR, average roughness, and tool wear) of SS316 have been investigated. Taguchi L27 orthogonal array based twenty seven experiments have been carried out by varying machining parameters at three levels. Feed rate has been identified as the most important parameter. Machining parameters have been optimized by grey entropy method to enhance the machinability. Optimal combination of machining parameters i.e. 170 m min−1 cutting speed, 0.5 mm/rev feed rate and 1.5 mm depth of cut produced the best machinability with 3.436 μm average roughness, 105187 mm3 min−1. MRR, and tool wear 234.63 μm. Lastly, a tool wear and chip morphology study have been done where textured tools have been found outperformed plain (Non-textured) tools.
Quantum technologies in Russia
Authors: Fedorov A K , Akimov A V , Biamonte J D , Kavokin A V , Khalili F Ya , Kiktenko E O , Kolachevsky N N , Kurochkin Y V , Lvovsky A I , Rubtsov A N , Shlyapnikov G V , Straupe S S , Ustinov A V , Zheltikov A M 
Published: November 2019

Abstract
Remarkable advancements in the ability to create, manipulate, and measure quantum systems are paving the way to build next generations of devices based on quantum physics. Quantum technologies in Russia are on the list of strategically important cross-cutting directions in the framework of the National Technology Initiative programs and the Digital Economy National Program. The broad focus includes quantum computing and simulation, quantum communications, quantum metrology and sensing. This paper reviews existing research on quantum science and technologies in Russia and summarizes the main goals for the next few years that form the basis of an upcoming major national initiative.
Delivering an Integrated Adolescent Multi-Agency Specialist Service to Families with Adolescents at Risk of Care: Outcomes and Learning from the First Ten Years
Authors: Talbot Laura , Fuggle Peter , Foyston Zoe , Lawson Kim 
Published: November 2019

Abstract
This article presents a ten-year service evaluation of the Adolescent Multi-Agency Specialist Service (AMASS), an edge of care service based within Islington Children’s Services. A description of the AMASS model and the social care and mental health outcomes for the cohort of families supported by the service across this period (n = 181) are presented. The service had a completion rate of 85 per cent and improvements in both social care and mental health outcomes were found for a significant proportion of those who completed the intervention. Placement stabilisation was achieved for 82 per cent of young people across the service’s three referral categories (home stability, foster placement stability and return home from care). Statistically significant reductions in parental report scores were found on the Strengths and Difficulties Questionnaire and two measures of family functioning in a paired sample (n = 48). Potential learning arising from the AMASS model, in terms of implications for service design for adolescent edge of care interventions, and the limitations of this service evaluation are discussed.
EXAMINING AGEISM IN UNDERGRADUATE STUDENTS THROUGH DRAWING
Authors: Terhune Katherina N , Guest Aaron , Kruger Tina M 
Published: November 2019

Abstract
Substantial demographic shifts in the U.S. will result in the growth of the aging population and the need for qualified professionals entering the field of aging. Yet, these emerging professionals have limited exposure to aging curricula. It is vital that gerontologists recognize the ageism present in how older adults and the aging process are viewed, as this ultimately impacts how they are treated. Data from 1,609 undergraduate surveys from the multi-institution, multi-year Gerontological Literacy Network can assist in our understanding emerging professionals’ perspectives. Results indicate students incorrectly associate aging with loss of function and a reliance on assistive devices (canes 29.3% and glasses 19.6%), physical changes (balding 27.3% and wrinkles 30.3%), and greater likelihood of being male (32.5%). Aging is thought of as time passing (16.1%) and death (14.2%). Findings reveal a need to reframe students’ understanding of aging from that of decline to recognizing the strengths associated with age.
AGE AND USE OF COMPLEMENTARY AND ALTERNATIVE MEDICINE
Authors: Halpin Sean N , Potapragaa Nivedita R , Bergquist Sharon H , Jarrett Thomas 
Published: November 2019

Abstract
Complementary and alternative medicines (CAM) are often obtained over the counter and not disclosed to health care practitioners—leading to possible unforeseen, harmful drug interactions. These concerns are especially true for older adults who have a high likelihood of experiencing multiple comorbidities. Yet few studies examine the patterns of CAM use and disclosure across a wide age range. We used a mixed-methods in a study on patient attitudes toward CAM in a large primary care setting. Participants (n=279) ranged in age from 21-85 (mean=58), were mostly white (75%), and had a bachelor’s degree or higher (83%). Most rated their physical health as good or very good (90%) and had a score of zero on the Charlson Comorbidity Index (76%). Use and disclosure of twelve types of CAM were assessed across three modalities including ingestible (e.g., herbs), psychological/mind-body (e.g., meditation), and physical (e.g., acupuncture). Age was not predictive of disclosure across the larger sample, but within respondents aged 65-85 (n=90), linear regression analyses showed likelihood of disclosure was associated with younger age, positive attitudes toward CAM, and expectation that their physician had positive attitudes about CAM. Semi-structured phone interviews (n=32) revealed older adults were more likely to have long-term CAM use, particularly for pain, and not feel it necessary to disclose to their physician. Meanwhile younger individuals reported trying CAM episodically for preventative health purposes. Understanding patterns of CAM use can help guide age-appropriate conversations and limit possible adverse outcomes from non-disclosure.
AGEISM FIRST AID: AN ONLINE COURSE DESIGNED TO ADVANCE GERONTOLOGY AND COMBAT AGEISM WITHIN THE HELPING PROFESSIONS
Authors: Reynolds Laurinda , Kruger Tina M , Knight Rebekah 
Published: November 2019

Abstract
Ageism First Aid is an online course designed to combat ageism, advance Gerontology, and generate revenue for Gerontology programs and GSA/AGHE activities. The project was funded by a grant from the Retirement Research Foundation and sponsored by the AGHE Academic Program Development Committee. The AFA course content is informed by developmental, social, and cognitive psychology, sociocultural and cognitive linguistics, speech-language science, and geriatrics. The content cultivates ageism awareness by replacing the common misconceptions about aging that underlie ageism with facts. The content also cultivates cultural consciousness and uses concise common language accessible to learners of diverse backgrounds. During this symposium, participants will be introduced to the course content and explore the benefits of this multidisciplinary approach to curriculum development. The results summary of the AFA course pilot will be presented as evidence of the course efficacy. Participants will leave able to utilize AFA within their institutions and local Aging Networks.
WORKING WITH OR WITHOUT AGING SPECIALISTS: WHERE ARE THE GERONTOLOGISTS?
Authors: Ewen Heidi H 
Published: November 2019

Abstract
One question asked by generations of gerontology doctoral students is what types of employment can be secured after completing the PhD in Gerontology. The Gerontology Education Longitudinal Study (GELS) has surveyed graduate students and alumni of the various doctoral programs in order to understand the career trajectories of graduates. Of 102 alumni surveyed in 2014 (42% response rate), the majority (60%) were not working with other people who had degrees in gerontology, yet 51% report working with at least some people who have experience with aging and older adults. On the job, graduates say that their duties require knowledge and mastery of public policy issues, health and medical aspects related to aging, and psychological theories. As aging experts, it is inherent in their work to combat ageism and reduce age-related stereotypes. As such, gerontologists are using substantive content expertise within their careers and serving as experts in aging.
ORGANIZATIONAL AND COMMUNITY FACTORS ASSOCIATED WITH NURSING HOME ORGANIZATIONAL CULTURE
Authors: Ghiasi Akbar , Davlyatov Ganisher K , Lord Justin C , Weech-Maldonado Robert 
Published: November 2019

Abstract
This study examines how organizational and community factors are associated with organizational culture among high Medicaid nursing homes (70% or higher Medicaid census). According to the Competing Values, Framework, there are four types of organizational culture: clan culture (friendly working environment); adhocracy culture (dynamic/creative working environment); market culture (results-based organization); and hierarchy culture (formalized/structured work environment). Survey data from 324 nursing home administrators (30% response rate) from 2017- 2018 were merged with secondary data from LTCFocus, Area Health Resource File, and Medicare Cost Reports. The dependent variable consisted of organizational culture type. The independent variables comprised organizational factors (facility has nurse practitioner/physician assistant (NP/PA), RN/LPN/CNA hours per resident day, RN skill mix, ownership, chain affiliation, size, occupancy rate, and Medicare and Medicaid payer mix) and community factors (Medicare Advantage penetration, per capita income, educational level, unemployment rate, poverty level and competition). Multinomial regression results showed that, compared to facilities with hierarchical cultures, those with a market culture have greater odds of having an NP/PA and higher RN skill mix and LPN intensity, but lower odds for RN intensity, Medicaid payer mix, occupancy rate, and Black residents. Also compared to facilities with hierarchical cultures, those with a clan culture have lower odds for having an NP/PA, beds and occupancy rate, but higher odds of being located in communities with lower unemployment and higher Medicare managed care. In conclusion, different organizational cultures are associated with different staffing patterns, as well as organizational and community factors.
ADVERSE CHILDHOOD EXPERIENCES PREDICTING INMATE STATUS AMONG OLDER COMMUNITY DWELLERS
Authors: Yang Mai S , Hedeker Donald 
Published: November 2019

Abstract
The goal of this study was to see if whether having exposure to early child adversity predicted inmate status among older adults. Very little research has focused on the relationship between inmate status and older adults, and factors that could predict someone being imprisoned. This study used data from the Health and Retirement Study (2006 – 2014) (N = 1,070) to examine this association. We used logit models to test if specific adverse childhood experience and race groups predicted inmate status among community dwellers age 55 and older (M = 72.2, SD = 8.5). More than half of the respondents were female (59%). About 1.9% respondent identified as non-Hispanic other, 7.2 % as Hispanics, 14.2% as non-Hispanic black, and 76.7% as non-Hispanic Whites. In terms of former inmate status 14% of the respondent indicated having been an inmate in jail or other correctional facility. Preliminary findings suggest predictors of inmate status were those who had trouble with the law in early adolescent years and those who self-reported as black. Findings from this study could provide insight into how early childhood experiences could predict inmate status in adulthood among older adults.
EFFECTIVENESS OF A COLLABORATIVE STEPPED-CARE MODEL FOR OLDER ADULTS WITH DEPRESSION
Authors: Lum Terry , Wong Gloria , Liu Tianyin , Lu Shiyu , Leung Dara , Sze Lesley , Sing Joyce , Kwok Weiwei 
Published: November 2019

Abstract
Background: Depression is common among older adults and creates a substantial burden on individuals, caregivers, and healthcare system. This paper presents an innovative collaborative stepped care intervention that promotes the coordination between elderly center and community mental health center to provide nonpharmacological intervention to elders with mild to moderate level of depression. Methods: The stepped care model were implemented in four districts in Hong Kong between September 2017 and February 2019. In each district, one community mental health center and one elderly center worked together to implement this stepped care model. A quasi-experimental design was used to study the effectiveness of this intervention. Findings: A total of 853 older adults completed the intervention and additional 500 elders were recruited as control. The average age of intervention participants was 76.3 years. Their levels of depression and anxiety were measured by Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder 7-item (GAD-7) respectively. The average intervention lasted for 10 months. Their average PhQ9 score reduced from 7.2 before intervention to 2.7 after intervention (t= 34.7, p &lt; .001). Their level of anxiety was lowered from 4.9 to 2.0 (t=16.9, p &lt; .001). The different between the intervention and control groups were statistically significant. Conclusion: The stepped care model was effective in reducing the levels of depression and anxiety among Chinese older people. This paper will give detailed information about the stepped care model and its implementation.
REDUCING DYSFUNCTIONAL BELIEFS ABOUT SLEEP PROVIDES LONG-TERM BENEFIT IN OLDER ADULTS WITH INSOMNIA
Authors: Song Yeonsu , Fung Constance , Dzierzewski Joseph , Mitchell Michael , Josephson Karen , Fiorentino Lavinia , Martin Jennifer , Alessi Cathy 
Published: November 2019

Abstract
Cognitive behavioral therapy for insomnia (CBTI) is recommended as first-line treatment in older adults. Changing dysfunctional beliefs and attitudes about sleep is an important component of CBTI, but the long-term impact of these changes are unknown, particularly in older adults. Methods involved secondary analyses of data from a large randomized controlled trial comparing CBTI (provided in 5 weekly sessions) to sleep education control, among older veterans with insomnia (N=159, mean age 72.2 years, 97% male, 79% non-Hispanic white). The purpose was to examine whether changes in a validated scale of Dysfunctional Beliefs and Attitudes about Sleep (DBAS) with CBTI treatment (baseline to post-treatment) was associated with later changes in self-reported sleep (post-treatment to 6 months follow-up). Sleep measures included Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS) and 7-day sleep diary measures. Analyses compared the slope of change in DBAS (baseline to post-treatment) between CBTI and control with respect to the slope of change in sleep outcomes (post-treatment to 6-months). Compared to controls, the CBTI group had stronger associations between DBAS improvement (baseline to post-treatment) and subsequent PSQI improvement (post-treatment to 6-months) (difference in slopes=1.3, 95% CI=[.52,2.1], p=0.001). This pattern of significant results was also found for ISI (difference in slopes=1.8, 95% CI=[.58,3.0], p=0.004) and ESS (difference in slopes=1.0, 95% CI=[.25,1.7], p=0.009). Slopes were not different for sleep diary measures. These findings suggest that changing dysfunctional beliefs and attitudes may continue to confer sleep benefits well after completion of CBT-I in older adults.