bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser atherectomy and drug‐coated balloons for the treatment of femoropopliteal in‐stent restenosis: 2‐Year outcomes
Authors: Kokkinidis Damianos G. , Behan Sean , Jawaid Omar , Hossain Prio , Giannopoulos Stefanos , Singh Gagan D. , Laird John R. , Valle Javier A. , Waldo Stephen W. , Armstrong Ehrin J. 
Published: December 2019

AbstractBackgroundFemoropopliteal (FP) artery is one of the most anatomically challenging areas for sustained stent patency. The incidence of FP in‐stent restenosis (ISR) is estimated at 50% at 24 months. Prior studies have shown that lesion debulking with laser atherectomy (LA) combined with drug coated balloon (DCB) have superior outcomes compared to LA + balloon angioplasty (BA) ISR, but there have not been studies evaluating 2‐year outcomes.MethodsThis was a dual‐center retrospective cohort study that compared patients with FP‐ISR treated with LA + DCB versus LA + BA. Cox regression analysis was used to examine 2‐year outcomes of target lesion revascularization (TLR) and the composite outcome of TLR or restenosis. Multivariable analysis was performed for clinical and statistically significant (in the univariate analysis) variables.ResultsOne hundred and seventeen consecutive patients with Tosaka II (n = 32) and III (n = 85) ISR were analyzed. Sixty‐six patients were treated with LA + DCB and 51 with LA + BA. The LA + DCB group had more lesions with moderate to severe calcification (58% vs. 13%; p < .0001). The LA + DCB group was more likely to be treated with the use of embolic protection devices (64% vs. 23%, p < .001) and cutting balloons (61% vs. 6%, p < .001). Bail‐out stenting rates were lower in the LA + DCB group (32% vs. 57%, p = .008). LA + DCB was superior (HR: 0.57; 95% CI: 0.34–0.9, p = .027) for the composite outcome of 2‐year TLR or restenosis. The 12‐month KM estimates for freedom from TLR or restenosis were 66% in the LA + DCB group versus 46% in the LA + BA group. The 24‐month KM estimates were 45% in the LA + DCB group versus 24% in the LA + BA group.ConclusionsThe combination of DCB + LA was associated with decreased rates of bail‐out stenting and improved 2‐year TLR or restenosis rates. Randomized clinical trials examining the DCB + LA combination for FP‐ISR are needed.
Nutritional and functional properties of durum wheat bran protein concentrate
Authors: Alzuwaid Nabeel T. , Sissons Mike , Laddomada Barbara , Fellows Christopher M. 
Published: December 2019

AbstractBackground and objectivesPlant industrial by‐products are relatively low cost and rich in organic material. Although these by‐products are a good source of various nutritional compounds, they represent the main disposal problem for the food industry. Wheat bran, one of the main by‐products of the wheat milling industry, contains more than 15% high‐quality proteins. However, these proteins are present in a form which is poorly digested as they are enclosed within a matrix of cell wall polysaccharides. About 15.5 million tonnes of usable protein could be recovered from bran if a commercial extraction process can be made viable. The purpose of this work was to extract protein from durum wheat bran using an alkaline acid method to study its nutritional and functional properties with the goal of using it as a fortifying material in cereal‐based foods such as pasta and bread.FindingsDurum wheat bran protein concentrate (WBPC) was prepared by using an alkaline extraction method (pH 9.5 for two hours) followed by isoelectric precipitation (pH 4.2). Chemical, nutritional, and functional properties of WBPC were obtained. WBPC had a protein content of ~61% (protein yield 20.5%–24.8%), containing also lipids, fiber, and small quantities of starch. WBPC was enriched in phytosterols compared to wheat bran (11.59 vs. 5.14 mg/g) with β‐sitosterol the predominant (4.37 mg/g). WBPC was also enriched in all the amino acids compared to bran, especially lysine and threonine. WBPC retained some phenolic acids, but at an eightfold lower quantity than in bran and retained about half the antioxidant activity (DPPH) of bran. WBPC showed excellent functional properties in terms of high solubility over a wide range in pH and good water and fat absorption capacity. The main protein components were albumin and globulin proteins.ConclusionThe extraction method used produced a protein concentrate in reasonable yield with high protein content enriched in essential amino acids and phytosterols compared to wheat bran with good functional properties and phenolic acids and antioxidant potential.Significance and noveltyThe nutritional and functional properties of WBPC make it a promising ingredient for various food products such as cereal and baked foods, processed meat, and beverages.
About a rare cause of a coxitis
Authors: Kaffel Dhia , Triki Wafa , Maatallah Kaouther , Ferjani Hanene , Riahi Hend , Jlalia Zied , Hamdi Wafa 
Published: December 2019

AbstractOO of the acetabulum can clinically and radiologically mimic an ankylosing spondylitis (with coxitis and sacroiliitis). Management of OO include multidisciplinary approach including radiologist, rheumatologist, and orthopedist.
Effects of Na2CO3/K2CO3 on Chemical Looping Combustion Using Fe2O3/Al2O3 as Oxygen Carrier
Authors: Zhang Zhifeng , Wang Yifei , Zhu Longchu , Li Jilin , Wang Fuchen , Yu Guangsuo 
Published: December 2019

AbstractThe performance of the Fe2O3/Al2O3 oxygen carrier modified by the alkali metals, Na and K, was studied by thermogravimetric analysis and in a laboratory‐scale fluidized‐bed reactor. Different factors, such as the alkali metal content, the alkali metal type, and the interaction between Na and K, were taken into account. Both Na and K had strong catalytic effects on the conversion of Fe2O3. A high K content caused serious agglomeration. Increasing the Na content led to slagging because of the low‐melting point solid solution. The possibility of agglomeration and slagging was reduced when Na and K were added together. The oxygen carrier with 1.5 wt % Na and 1.5 wt % K had better combustion efficiency and optimal thermal stability. Na and K could enhance the attrition resistance and prolong the lifetime of the oxygen carriers.
An Ordered Mesoporous Carbon Nanofiber Array for the Sensitive Electrochemical Detection of Malachite Green
Authors: Yang Beibei , Bin Duan , Tian Tongtong , Liu Yun , Liu Baohong 
Published: December 2019

AbstractThe recycling of environmental wastes to produce value‐added materials is an attractive prospect for both economic and social development. Herein, we use natural crab shell as the templates to synthesize ordered mesoporous carbon nanofiber arrays (OMCNs) based on a combined hard‐templating and surfactant self‐assembly approach. The Brunauer‐Emmett‐Teller surface area of the OMCNs is calculated to be 1200 m2 g−1, which is accompanied by good conductivity and a mesoporous structure. The as‐prepared OMCNs exhibit a remarkable electrochemical performance for the detection of malachite green (MG). Differential pulse voltammetry (DPV) reveals that the MG sensor has a wide linear range from 0.1 μM to 22.1 μM with a low detection limit of 0.05 μM. The MG sensor also shows a good stability and excellent anti‐interference, which are investigated by cyclic voltammetry. Furthermore, such an electrochemical sensor is successfully applied for the determination of MG in fishery water samples.
Entrainment Control Using a Newly Developed Telecentric Inline Probe
Authors: Schulz Jonas , Schäfer Kevin , Bart Hans‐Jörg 
Published: December 2019

AbstractThis contribution presents a novel approach to investigate entrainment in distillation and absorption columns. An image‐based probe allows precise droplet detection at various radial and axial positions above trays. Validations achieve an average error of 6.4 % (monospheres 9.2–114.4 µm) and 3 % (monodisperse droplet stream up to 19 m s−1 and 74.5 µm). Experiments in a DN 450 cold flow test rig show an increasing (decreasing) share of larger droplets with higher gas (liquid) loads. Locally measured droplet sizes depend on probe position as well as tray design and enable an extrapolation to integral entrainment rates.
Research on partitioning algorithm based on RDF graph
Authors: Zheng Zhi‐yun , Wang Chen‐yu , Ding Yang , Li Lun , Li Dun 
Published: December 2019

SummaryWith the increasing size of the RDF dataset, the application of parallel computing frameworks is applying more and more widely in big data. In order to realize the parallel query of data, an edge partitioning algorithm is proposed based on RDF sentence graph. Firstly, the algorithm transforms the RDF graph into an RDF sentence graph using coarsening and partitioning. Secondly, the minimum degree vertex partitioning algorithm is put forward to partition the RDF sentence graph. Finally, according to the equivalence thought between edge segmentation of RDF sentence and vertex segmentation of RDF graph, the intersection between RDF subgraphs is the vertex cut set of RDF graph to achieve parallel query of RDF data. The experimental results show that the algorithm's partitioning time and efficiency are better than the traditional algorithms.
Isolation of High‐Quality RNA from Pichia pastoris
Authors: Öztürk Sibel , Demir İrem , Çalık Pınar 
Published: December 2019

AbstractAnalysis of RNA structuromes provides new insights into cellular processes, enabling systems biology and biotechnology researchers to calculate promoter and terminator strengths and to directly observe how differing circuit states impact host gene expression and the burdens imposed by the circuits. Such analysis, however, is crucially dependent on the availability of highly pure, intact RNA isolated from fresh or frozen cell cultures. RNA extraction from the yeast Pichia pastoris requires specific pretreatment steps to ensure the reproducibility of downstream applications, but current methods and extraction kits are generally adapted for the conventional yeast Saccharomyces cerevisiae, which has a different cell wall composition. We therefore set out to compare the efficacy of two different RNA isolation methods when applied to P. pastoris: (i) phenol/chloroform extraction and (ii) silica spin‐column absorption. We compared the yield, integrity, and purity of the resulting isolated RNA from the two methods (using two different types of commercial columns for silica spin‐column absorption) and further optimized them through variations in the pretreatment steps. We also assessed two different methods of cell lysis: enzyme catalytic disruption using lyticase and mechanical disruption using acid‐washed glass‐beads in a TissueLyser. © 2019 by John Wiley & Sons, Inc.Basic Protocol 1: RNA isolation with phenol/chloroform extraction: monophasic lysis reagentAlternate Protocol 1: RNA isolation with silica‐spin column absorption: High Pure RNA Isolation Kit (Roche Life Science)Alternate Protocol 2: RNA isolation with silica‐spin column absorption: RNeasy Mini Kit (Qiagen)
Influence of flow shear on localized Rayleigh–Taylor and resistive drift wave instabilities
Authors: Zhang Yanzeng , Krasheninnikov Sergei I. , Smolyakov Andrei I. 
Published: December 2019

AbstractThe impact of velocity shear on the localized solutions of Rayleigh–Taylor (RT) and resistive drift wave (DW) instabilities has been investigated. Slab geometry is used, and the plasma density gradient is assumed to have a finite spatial structure. It demonstrates that the velocity shear has quite different effects on these instabilities: while it stabilizes RT instability and causes tilting of the eddies of equipotential contour, it has a very mild impact on the resistive DW instability and simply shifts the eddies with no tilting.
Affinity propagation‐based interference‐free clustering for wireless sensor networks
Authors: Lin Hai , Chen Zhihong , Li June 
Published: December 2019

SummaryWireless sensor networks (WSNs), eg, industrial WSNs, require reliability and real‐time communication. Clustering technique together with schedule‐based access can provide the benefits, such as energy saving, reliability, and timeliness. However, integrating above two technologies into WSNs requires sophistical time slot allocation mechanism. To simplify the time slot allocation, the paper proposes a distributed interference‐free clustering algorithm for WSNs. The algorithm is inspired by affinity propagation (AP) clustering algorithm. By adapting and improving the original AP algorithm, the proposed clustering algorithm aims to jointly optimize energy saving and coverage issues while providing interference free between clusters. The performance analysis demonstrates that it can achieve high receiving rate (reliability), low delay (real time), and low‐energy consumption.
Sleep deprivation decreases the reproductive capacity by affecting the arrival of morulas in the uterus
Authors: Calegare Bruno Frederico Aguilar , Azzolini Augusto , da Silva Vallim Julia Ribeiro , Turco Edson Guimarães Lo , Tempaku Priscila Farias , da Silva Vanessa Cavalcante , Tufik Sergio , D'Almeida Vânia 
Published: December 2019

SummaryA previous animal study by our group found that sleep deprivation during preimplantation was associated with decreased pregnancy maintenance. Given its impact on human society, we aimed in the current study to assess whether sleep deprivation affects blastocyst gene expression and/or the implantation process. For this, pregnant mice (gestational day 0 [GD 0]) were assigned into paradoxical sleep deprivation (SD, 72 hr; multiple platform method) and, a control (CT) group. Animals were euthanized on GD 3.5 and blood, uterus (embryos) and fallopian tube were collected. Then, 89% of CT presented blastocysts in the uterus versus 25% from SD group. Compared to CT, SD presented lighter relative uterus weight, increased plasma concentrations of corticosterone and testosterone, decreased concentrations of progesterone and luteinizing hormone, but no statistical differences in plasma concentrations of 17β‐estradiol and follicle stimulating hormone. There were no differences in uterus and blastocyst gene expression related to embryo implantation and development, and no alteration in blastocysts global DNA methylation. Considering this, the decreased pregnancy maintenance after sleep deprivation seems not to be associated with implantation losses or developmental problems related to the blastocysts. It is likely that complications in morula development and/or its movement through the fallopian tubes affect the pregnancy rate, since only 25% of SD females presented a blastocyst on the GD 3.5. In fact, three out of four females without blastocysts in the uterus presented morula in the fallopian tubes due to a phase delay. Additionally, we suggest that the observed hormonal changes may play a role in this outcome.
Morphological and molecular characterization of freshwater prawn of genus Macrobrachium in the coastal area of Cameroon
Authors: Makombu Judith G. , Stomeo Francesca , Oben Pius M. , Tilly Eldridge , Stephen Opiyo O. , Oben Benedicta O. , Cheruiyot Evans K. , Tarekegn Getinet Mekuriaw , Zango Paul , Egbe Atem E. , Ndagyong Abigail , Mialhe Eric , Ngueguim Jules R. , Mujibi Fidalis D. N. 
Published: December 2019

AbstractMacrobrachium (Bate, 1868) is a large and cosmopolitan crustacean genus of high economic importance worldwide. We investigated the morphological and molecular identification of freshwater prawns of the genus Macrobrachium in South, South West, and Littoral regions of Cameroon. A total of 1,566 specimens were examined morphologically using a key described by Konan (Diversité morphologique et génétique des crevettes des genres Atya Leach, 1816 et Macrobrachium Bate, 1868 de Côte d'Ivoire, 2009, Université d'Abobo Adjamé, Côte d'Ivoire), leading to the identification of seven species of Macrobrachium: M. vollenhovenii (Herklots, 1857); M. macrobrachion (Herklots, 1851); M. sollaudii (De Man, 1912); M. dux (Lenz, 1910); M. chevalieri (Roux, 1935); M. felicinum (Holthuis, 1949); and an undescribed Macrobrachium species M. sp. To validate the genetic basis of the identified species, 94 individuals representing the species were selected and subjected to genetic characterization using 1,814 DArT markers. The admixture analysis revealed four groups: M. vollenhovenii and M. macrobrachion; M. chevalieri; M. felicinum and M. sp; and M. dux and M. sollaudii. But, the principal component analysis (PCA) separated M. sp and M. felicinum to create additional group (i.e., five groups). Based on these findings, M. vollenhovenii and M. macrobrachion may be conspecific, as well as M. dux and M. sollaudii, while M. felicinum and M. sp seems to be different species, suggesting a potential conflict between the morphological identification key and the genetic basis underlying speciation and species allocation for Macrobrachium. These results are valuable in informing breeding design and genetic resource conservation programs for Macrobrachium in Africa.
Does intensive goose grazing affect breeding waders?
Authors: Madsen Jesper , Marcussen Luna Kondrup , Knudsen Niels , Balsby Thorsten Johannes Skovbjerg , Clausen Kevin Kuhlmann 
Published: December 2019

AbstractIncreasing goose population sizes gives rise to conflicts with human socioeconomic interests and in some circumstances conservation interests. Grazing by high abundances of geese in grasslands is postulated to lead to a very short and homogeneous sward height negatively affecting cover for breeding meadow birds and impacting survival of nests and chicks. We studied the effects of spring grazing barnacle geese Branta leucopsis and brent geese Branta bernicla on occupancy of extensively farmed freshwater grasslands by nesting and brood‐rearing waders on the island Mandø in the Danish Wadden Sea. We hypothesized that goose grazing would lead to a shorter grass sward, negatively affecting the field occupancy by territorial/nesting and chick‐rearing waders, particularly species preferring taller vegetation. Goose grazing led to a short grass sward (<5 cm height) over most of the island. To achieve a variation in sward height, we kept geese off certain fields using laser light. We analyzed effects of field size, sward height, mosaic structure of the vegetation, proximity to shrub as cover for potential predators, and elevation above ground water level as a measure of wetness on field occupancy by nesting and chick‐rearing waders. The analysis indicated that the most important factor explaining field occupancy by nesting redshank Tringa totanus, black‐tailed godwit Limosa limosa, oystercatcher Haematopus ostralegus and lapwing Vanellus vanellus as well as by chick‐rearing black‐tailed godwit and lapwing was short vegetation height. Distance to shrub cover and elevation were less important. Hence, despite very intensive goose grazing, we could not detect any negative effect on the field occupancy by nesting nor chick‐rearing waders, including redshank and black‐tailed godwit, which are known to favor longer vegetation to conceal their nests and hide their chicks. Possible negative effects may be buffered by mosaic structures in fields and proximity to taller vegetation along fences and ditches.
European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose‐lowering drugs in patients with heart failure
Authors: Seferović Petar M. , Coats Andrew J.S. , Ponikowski Piotr , Filippatos Gerasimos , Huelsmann Martin , Jhund Pardeep S. , Polovina Marija M. , Komajda Michel , Seferović Jelena , Sari Ibrahim , Cosentino Francesco , Ambrosio Giuseppe , Metra Marco , Piepoli Massimo , Chioncel Ovidiu , Lund Lars H. , Thum Thomas , De Boer Rudolf A. , Mullens Wilfried , Lopatin Yuri , Volterrani Maurizio , Hill Loreena , Bauersachs Johann , Lyon Alexander , Petrie Mark C. , Anker Stefan , Rosano Giuseppe M.C. 
Published: December 2019

ABSTRACTType 2 diabetes mellitus (T2DM) is common in patients with heart failure (HF) and associated with considerable morbidity and mortality. Significant advances have recently occurred in the treatment of T2DM, with evidence of several new glucose‐lowering medications showing either neutral or beneficial cardiovascular effects. However, some of these agents have safety characteristics with strong practical implications in HF [i.e. dipeptidyl peptidase‐4 (DPP‐4) inhibitors, glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA), and sodium–glucose co‐transporter type 2 (SGLT‐2) inhibitors].Regarding safety of DPP‐4 inhibitors, saxagliptin is not recommended in HF because of a greater risk of HF hospitalisation. There is no compelling evidence of excess HF risk with the other DPP‐4 inhibitors. GLP‐1 RAs have an overall neutral effect on HF outcomes. However, a signal of harm suggested in two small trials of liraglutide in patients with reduced ejection fraction indicates that their role remains to be defined in established HF. SGLT‐2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) have shown a consistent reduction in the risk of HF hospitalisation regardless of baseline cardiovascular risk or history of HF. Accordingly, SGLT‐2 inhibitors could be recommended to prevent HF hospitalisation in patients with T2DM and established cardiovascular disease or with multiple risk factors. The recently completed trial with dapagliflozin has shown a significant reduction in cardiovascular mortality and HF events in patients with HF and reduced ejection fraction, with or without T2DM. Several ongoing trials will assess whether the results observed with dapagliflozin could be extended to other SGLT‐2 inhibitors in the treatment of HF, with either preserved or reduced ejection fraction, regardless of the presence of T2DM. This position paper aims to summarise relevant clinical trial evidence concerning the role and safety of new glucose‐lowering therapies in patients with HF.
Acheta domesticus (Cricket) feed resources among smallholder farmers in Lake Victoria region of Kenya
Authors: Oloo Jackline A. , Ayieko Monica , Nyongesah John Maina 
Published: December 2019

AbstractThe quality of domesticated crickets depends on the choice of feed substrate that has a direct impact on the economic viability of the farming operation. This study assessed the popular local cricket feeds in the Lake Victoria region. Data were collected through individual interviews, focus group discussions, personal observations, and growth experiments. Kales, sweet potato leaves, ugali, and banana peels were the most preferred by the farmers. Crickets fed on kales and sweet potatoes had a significantly higher weight gain and maturity rate than those fed on ugali and banana peels (p < .05). Additionally, crickets fed on kales and sweet potatoes had higher (82.4% and 78.6%, respectively) crude proteins compared to those fed on ugali (57.9%) and banana peels (62.9%). Kales and sweet potatoes can serve as cheaper, alternative local feeds for cricket farming. Empowerment of farmers through subsidies or provision of loans can enhance local cricket feed production.
Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources
Authors: Ghramh Hamed A. , Ibrahim Essam H. , Kilany Mona 
Published: December 2019

AbstractSidr honey is used as food and medicine in many countries. Study of immunomodulatory and anticancer activity of Sidr honey did not tested before. The aim of this work was to study the anticancer activity and immunomodulatory as well as antimicrobial potential of Sidr honey and its synthesized silver nanoparticles (AgNPs). Sidr honey from three sources (two from Kingdom of Saudi Arabia (KSA) and one from Pakistan) was diluted to 20% and tested for its biological activities and to synthesize AgNPs. The results demonstrated that honeys could produce AgNPs (spherical shape), modulated the growth of normal splenic cells, and have antimicrobial activities. Sidr honey has anticancer activity against HepG2 but not Hela cells. Sidr honey can be used as antimicrobial agent, but can be used as anticancer agent with care as it stimulated cell growth of some lines (e.g., Hala) and inhibited another (e.g., HepG2).