bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPETITIVE PRIORITIES IN THE URBAN MOBILITY SECTOR
Authors: Oshiro Estela Tieko , Guimarães Márcia Regina Neves , Lara Felipe Ferreira de 
Published: November 2020

Purpose – The research aims to identify the competitive priorities adopted by a company that operates in the urban mobility services sector and analyzes practices and strategies that reinforce the priorities adopted.Design/methodology/approach – Exploratory case study from a qualitative approach, through semi-structured interviews with four actors relevant to the development of the research problem.Findings – It was possible to observe that the technologies for mobility allows the implementation of innovation based on the perception of the customer's desire, which, in the case of this research, had quality as the central element. A central point identified was the fact that the company under study used innovation when customizing products to maintain competitive levels of quality and differentiation through service innovations. On the other hand, there is a restriction with a greater impact, which is the fact of the difficulty in controlling the levels of services performed by drivers.Originality/value – The research contributes to a better understanding of the customer's needs in the urban mobility services sector, and in order to guarantee higher customer satisfaction and improve the level of quality in the supply of services, resulting in performance and competitive advantage for companies in the sector. Keywords - Competitive priorities; quality; services; innovation.
Barriers to Corporate Social Responsibility: the perceptions of a leading non-governmental organization
Authors: Delmonico Diego Valerio de Godoy , Santos Hugo Henrique dos , Luiz Octaviano Rojas , Luiz João Victor Rojas , Bezerra Bárbara Stolte , Battistelle Rosane Aparecida Gomes 
Published: November 2020

Purpose – This study aims to identify the main barriers to develop Corporate Social Responsibility (CSR) from the viewpoint of a leading Non-governmental Organization (NGO). The proposed methodology evaluates the importance attached to different classes of barriers to CSR from the privileged perspective of a Brazilian NGO.Theoretical framework – This study was based on the current theory of barriers to CSR initiatives and multicriteria decision making.Design/methodology/approach – The Analytic Hierarchy Process (AHP) method was used to assess and prioritize barriers to CSR through expert opinion. The ranking of stability was tested through a sensitivity analysis of the assigned weights.Findings – The results indicate that the main barrier is a lack of commitment of senior management. By contrast, the least determining barriers were a lack of social auditing, diversity, and customer awareness.Originality/value – The article contributes by extending the application of multiple-criteria decision-making methods to CSR and evaluating the relative importance of the barriers. This study also offers empirical results that broaden the discussion on barriers to social responsibility, guiding managers and decision makers who lead CSR initiatives in organizations to understand which barriers should be overcome, and where managers should focus their effects to do so. Keywords - Analytic hierarchy process; Multicriteria decision making; CSR; Non-governmental organizations; Sustainable development.
PROJECT DEVELOPMENT IN SMALL AND MEDIUM-SIZED ENTERPRISES: AN OPPORTUNITY TO IMPROVE TEACHING AND UNIVERSITY-BUSINESS INTERACTION
Authors: Rodrigues José de Souza , Dalpian Aline Martins Schneiders , Zambon Kátia Lívia , Crepaldi Antonio Fernando , Azzolini Júnior Walther 
Published: November 2020

Purpose: Assess whether project development in Small and Medium-sized Enterprises that supports the teaching-learning process (PBL methodology - Project Based Learning) is a solution to overcome the challenges of training professionals in the 21st century.Theoretical framework: Project development allows the student to be active in the teaching-learning process and enables technical and behavioral skills to be developed. Studies with SMEs are needed since it has not been researched greatly.Design/methodology/approach: Applied Research and the methodological approach were used for the case study. Projects were developed in two small enterprises and data was collected on students' opinions regarding the process, where participant observation, documentation and interviews were used. Data was obtained in the period 2016 and 2017 in the region of Bauru-SP, Brazil, in partnership with SEBRAE (Brazilian Micro and Small Enterprise Support Service).Findings: The methodology based on project development in small enterprises motivates students and develops transferable skills which generates benefits for companies.Research, Practical & Social implications: Small enterprises provide the opportunity to look at companies as a whole and interact with all their employees, bringing the university closer to the community.Originality/value: small businesses can contribute to improving education by allowing collaborative university-company projects to develop.Keywords: PBL, small and medium-sized enterprises, engineering education, production systems
The crisis of criminal justice in South Africa
Authors: Cameron Edwin 
Published: November 2020

This article builds on two lectures (delivered in 2017 and 2019 at the University of the Western Cape and the University of Cape Town respectively) that addressed a a controversial and often overlooked crisis in the criminal justice system – the minimum sentencing regime. The paper argues that minimum sentences are no response at all to curbing crime in South Africa and to making our people safe. The minimum sentencing regime is a misdirected, hugely costly and above all ineffective way of punishing criminals and dealing with crime. It has been an extravagant mistake of science, understanding, and policy and social response. The article summarises some of the arguments and considers why we are still stuck with minimum sentences when they are demonstrably useless and counterproductive. The author argues that the reasons lie in our broken history, in incoherent decision-making in our present political leadership, institutional incompetence, and the fact that minimum sentences themselves, through their false promise, divert us from finding more efficient solutions.
INCIDENTAL FINDINGS OF MALIGNANCY OF THE CHEST BY SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION – One YEAR FOLLOW-UP REPORT.
Authors: Tung Robert , Heyns Johannes 
Published: November 2020

Background: We recently reported 6 cases of pulmonary/hilar malignancies as the result of incidental findings (IF) on CT attenuation correction (CTAC) during SPECT-CT MPI. In this study, we examined clinical features, diagnostic procedures and clinical outcome on all patients who were had malignancies or significant IF that required further follow-up. Methods: Of 1098 consecutive patients who underwent cardiac SPECT-CT MPI from 9/1/2017 to 8/31/2018, their MPI and CTAC were reviewed contemporaneously. Patients with known history of prior pulmonary or chest malignancy were excluded. Results: A total of 79 (7.2%) patients were identified to have significant IF on CTAC; after diagnostic CT, 47 patients were found to have significant findings that warranted further follow-up and included in this study. Eight patients (0.73%) were found to have malignancy of the chest because of IF on the CTAC. There was no statistical difference in baseline characteristics and cancer risk factors among patients who were found to have cancer vs those without. At the time of diagnosis, 4 patients were found to have cancer at advanced stage who all died within 12 months while 3 others had lung cancer of early stage and 1 mantle cell lymphoma were alive at a mean follow-up of 17.5+/-2.1 months. Biopsy for tissue diagnosis were performed safely: with needle biopsy, major complication occurred in 1 patient (1/9 or 11.1%); none with surgical biopsy. Conclusions: This study underscores the importance of reviewing CTAC images obtained during cardiac SPECT-CT MPI to potentially detect clinically important incidental findings.
Ankilozan Spondilitli Hastalarda Nöropatik Bel Ağrısı ve Hastalık Aktivitesi, Fonksiyonel kapasite ve Yaşam kalitesi ile İlişkisi
Authors: YILDIRIM Tülay 
Published: November 2020

Amaç: Bu çalışmada Ankilozan spondilit (AS)’li hastalarda bel ağrısının nöropatik komponentinin değerlendirmesi ve nöropatik ağrının; hastalık aktivitesi, fonksiyonel kapasite ve yaşam kalitesi ile ilişkisini araştırması amaçlandı.
Gereç ve yöntemler: Çalışmaya 15 AS tanılı hasta dahil edildi. Hastalık aktivitesini değerlendirmek için Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI), fonksiyonel durumu değerlendirmek için Bath Ankylosing Spondylitis Functional Index (BASFI), ve yaşam kalitesini değerlendirmek için Ankylosing Spondylitis Quality of Life (ASQoL), bel ağrısının şiddetinin değerlendirmek için visual analog scale (VAS), nöropatik ağrıyı değerlendirmek için ise painDETECT anketi kullanıldı.
Bulgular: PainDETECT skoru hastaların % 13'ünde kesin nöropatik ağrı, % 33'ünde ise olası nöropatik ağrı saptandı. PainDETECT skorları ile bel ağrısı VAS değerleri, BASFI ve CRP düzeyleri arasında anlamlı düzeyde pozitif korelasyon saptandı (p
Analysis of genetic aberrations in pediatric high-grade gliomas
Authors: Zaytseva M. A. , Shekhtman A. P. , Papusha L. I. , Valiakhmetova E. F. , Yasko L. A. , Druy A. E. 
Published: November 2020

Background. High-grade gliomas are characterized by a wide range of genetic abnormalities. The heterogeneous genomic landscape of pediatric high-grade gliomas allows identifying distinct subgroups of the disease in children and young adults. Most importantly, these subgroups differ by clinical course and prognosis, as well as treatment response to standard therapy.Objective: to assess the profile of molecular genetic markers of high-grade gliomas in children.Materials and methods. In the current study, we examine the frequency of H3F3A, Hist1H3B, BRAF, IDH1 / 2 mutations, the copy number alterations of CDKN2A / 2B genes and the expression of ETV6‑NTRK3 fusion gene in a cohort of 53 pediatric high-grade gliomas.Results. Driver mutations and CDKN2A / 2B deletions were observed in 24 (45 %) and 15 (28 %) of 53 tumors, respectively. Overall, the studied high-grade gliomas harbored 41 genetic aberrations including 24 (58.5 %) somatic missense mutations, 1 (2.4 %) genetic variant of unknown clinical significance, 1 (2.4 %) oncogenic fusion gene and 15 (36.6 %) deletions of the tumor suppressor genes.Conclusion. These findings point to the importance of molecular profiling of tumors for the optimal clinical care and development of new approaches to treatment aimed at molecular targets for personalized anticancer therapies.
Aktivitas berjalan meningkatkan bone mineral density pada perempuan pascamenopause
Authors: Savitri Evita Peninta Dwi , Herwana Elly 
Published: November 2020

LATAR BELAKANGOsteoporosis merupakan penyakit tulang yang ditandai dengan rendahnya bone mineral density (BMD) disertai perubahan pada mikroarsitektur tulang. BMD yang rendah menandai adanya penurunan kepadatan pada tulang dan meningkatkan risiko terjadinya fraktur. Penurunan kadar estrogen pada kondisi pascamenopause, gaya hidup yang meliputi aktivitas fisik dan kebiasaan berjalan sangat berperanan dalam progresivitas osteoporosis. Penelitian ini bertujuan menilai hubungan antara aktivitas berjalan dengan kepadatan tulang pada perempuan pascamenopause.
METODEPenelitian analitik observasional dengan metode cross-sectional dilakukan pada perempuan pascamenopause berusia 45-70 tahun pada periode Agustus-Oktober 2018. Penilaian aktivitas berjalan dilakukan dengan menggunakan kuesioner dan wawancara. Aktivitas berjalan dinilai dari jumlah langkah berjalan/hari yang dikonversikan dari jarak tempuh subjek berjalan kaki setiap harinya. Pengukuran BMD menggunakan calcaneal quantitative ultrasound (QUS), hasil pengukuran BMD membedakan kepadatan tulang berdasarkan nilai-T. Analisis data dilakukan dengan uji statistik Chi Square dengan tingkat kemaknaan p<0.05.
HASILSebanyak 88 perempuan pascamenopause ikut berpartisipasi sebagai subjek penelitian dengan usia (rerata ± simpang baku) 57.91 ± 7.25 tahun. Distribusi aktivitas berjalan didapatkan 71 (80.7%) kurang aktif, 12 (13.6%) aktivitas sedang, dan 5 (5.7%) aktif. Distribusi hasil penilaian kepadatan tulang didapatkan sebanyak 18 (20.5%) normal, 49 (55.75%) osteopenia dan 21 (23.9%) osteoporosis. Hasil analisis statistik menunjukkan terdapat hubungan yang bermakna antara aktivitas berjalan dan kepadatan tulang pada perempuan pascamenopause (p=0.009).
KESIMPULANTerdapat hubungan yang bermakna antara aktivitas berjalan dan kepadatan tulang pada perempuan pascamenopause.
Predictors of Coronary Plaque Vulnerability in Patients with Stable Coronary Artery Disease
Authors: Kochergin N. A. , Kochergina A. M. , Ganyukov V. I. , Barbarash O. L. 
Published: November 2020

Aim To identify new predictors for vulnerability of atherosclerotic coronary plaques in patients with stable ischemic heart disease (sIHD).Material and methods This prospective, single-center study included 58 patients with sIHD. Unstable plaques were detected with virtual histology intravascular ultrasound of proximal and medium segments of a coronary artery without significant lesions according to coronarography data. Indexes of inflammation, dyslipidemia and carbohydrate metabolism were considered as candidate predictors for coronary plaque vulnerability.Results In 56 coronary arteries, 58 plaques were detected, 12 of which (20.7 %) were unstable. Vulnerable plaques differed morphologically from stable ones by a greater size of the necrotic core (35.1±8.5 % vs. 24.0±13.2 %; р=0.008), calcified nodules (2.0 [1.0; 5.0] % vs. 1.0 [0; 2.0] %; р=0.006), and a lower content of fibrous components (54.9±10.2 % vs. 66.4±15.8 %; р=0.02). In addition, vulnerable plaques more frequently narrowed the arterial lumen by >70 % of the lumen area (33.3 % vs. 2.2 %; р=0.0006). Correlation analysis showed a negative correlation between the level of high-density lipoproteins (HDL) and calcium volume (r= –0.4104; р=0.023); a positive correlation between the blood glucose level as determined by the oral glucose tolerance test and the lipid component (r=0.48198; р=0.033); and a negative correlation between the apolipoprotein A level and the calcium volume (r= –0.4297; р=0.008).Conclusion The study demonstrated a high prevalence of vulnerable plaques in nontarget coronary arteries in patients with sIHD. In this process, dyslipidemia indexes (LDL, apolipoproteins A) correlate with the calcium volume whereas blood glucose, as measured in the oral glucose tolerance test, correlates with the lipid component of coronary plaque.
Genetic Variants rs1049255 CYBA and rs2333227 MPO are Associated with Susceptibility to Coronary Artery Disease in Russian Residents of Central Russia
Authors: Bushueva O. Yu. 
Published: November 2020

Aim To study association of single-nucleotide polymorphisms rs1049255 CYBA and rs2333227 MPO with development of ischemic heart disease (IHD) in Russian residents of Central Russia.Material and methods The study material was DNA samples from 436 patients with IHD (265 men, 171 women; mean age, 61 years) and 370 sex- and age-matched arbitrarily healthy volunteers (209 men, 161 women; mean age, 60 years). Genotyping was performed by allelic discrimination with TaqMan probes.ResultsComparative analysis of genotype frequency (log-additive regression model) showed that SNP rs1049255 CYBA (odds ratio, OR, 0.79 at 95 % confidence interval, CI, from 0.65 to 0.96; p=0.02) and rs2333227 MPO (OR 0.72 at 95 % CI from 0.55 to 0.95; p=0.02) were associated with a decreased risk of IHD adjusted for sex and age. Analysis of sex-specific effects showed that the protective effect of rs1049255 CYBA was evident only in men (OR 0.72 at 95 % CI from 0.55 to 0.94; p=0.16).Conclusion The study demonstrated a protective effect of rs1049255 CYBA and rs2333227 MPO with respect of IHD in Russians. The protective effect of rs1049255 CYBA was observed only in men.
A study of etiology, clinical characteristics, electrocardiographic and echocardiographic findings in patients with cardiac tamponade in a tertiary care hospital in Western Odisha
Authors: Patel Nayan Kumar , Sharma Sunil Kumar , Roy Ayan 
Published: November 2020

Background: Cardiac tamponade is a life-threatening condition characterized by elevated intracardiac pressure, limitation of diastolic filling, and reduction of cardiac output and mostly requires urgent therapeutic intervention. Pericardial disease in on the rise attributed to improved survival of malignancy, growing no of cardiac interventions, chronic kidney diseases with dialysis, advent of modern chemo-radiotherapy. Still, there are paucity of data on etiology, clinical characteristics, electrocardiogram (ECG) and echocardiographic features in patients with cardiac tamponade from Odisha. Aim of this study was to emphasize the etiology, clinical characteristics, electrocardiographic and echocardiographic features in patients with cardiac tamponade.Methods: A prospective observational study of 1-year duration was undertaken for patients with cardiac tamponade admitted at VIMSAR, a cardiology unit. Data on etiology, clinical characteristics, Echocardiography, ECG findings were documented. Echo guided pericardiocentesis followed culture, cytological and biochemical analysis done.Results: Most common symptom was dyspnoea (88%), clinical signs were tachypnoea (96%), raised jugular venous pulse (64%), tachycardia (84%), pulsus paradoxus (60%). Classical beck’s triad was seen in 42% cases. X-ray showed cardiomegaly (94%) & pleural effusion (64%). Common ECG findings were sinus tachycardia (84%), low voltage QRS (68%) and electrical alternans (44%). Echocardiography showed 80% and 68% of patients had right atrium collapse and right ventricle collapse respectively. Both inferior vena cava plethora and transmitral flow variation were seen in 88% of cases. 96% had normal left ventricle function. 80% had large effusion. Pericardiocentesis yield was mostly in between 500-1000ml (mean 908 ml) with 72% with haemorrhagic aspirate. All malignancy cases and 76% tubercular cases had haemorrhagic effusion. Most common etiology was tubercular (50%), followed by malignancy (28%). 6% remained idiopathic. chronic kidney disease, systemic lupus erythematosus, post MI intervention, hypothyroid were some of the other causes.Conclusions: Initial assessment with investigation and careful follow-up can yield a causal diagnosis in most cases. Early diagnosis and intervention by pericardiocentesis can be lifesaving.
Endometriosis a brief review: evaluation of crucial risk factors and current treatment regimes
Authors: Ashish Ashish , Kusum Kusum , Rai Sangeeta , Singh Royana 
Published: November 2020

Endometriosis is an estrogen-dependent chronic inflammatory disease associated with substantial morbidity, including dyspareunia, dysmenorrhea, pelvic pain, multiple surgery, and infertility. This disease has a high impact on both woman’s physical and mental wellbeing. The etiology of endometriosis is complex and multifactorial. The risk factors associated with the development of endometriosis include family history, menstrual and reproductive cycle, low body mass index (BMI), diet, alcohol uses, smoking, environmental factors, immune system, genetic factors and intrinsic abnormalities in the endometrium. There exist many theories on the initiation and propagation of different types of endometriotic lesions and consequent biological disturbances, of which the most common is the Sampson’s theory according to which the retrograde flow of menstrual blood is linked to the development of endometriosis. Endometriosis affected women have a higher risk than the general female population, for ovarian cancer, coronary heart disease (CHD), and other long-term disease risks as well for autoimmune and atopic disorders. Therefore it becomes a necessity for the clinician not only to attain right diagnosis but also follow up for the other associated disorders. In this review, we have considered the crucial risk factors and biomarkers of the endometriosis as well as the possible pathogenesis towards the development of endometriosis and its prevention strategies. The currently available therapies for the control and treatment of endometriosis have also been elaborated.
Anaesthesia for a child with glucose-6-phosphate-dehydrogenase deficiency: a case report
Authors: Munasinghe Baththirange Malaka , Nimalan Srisothinathan , Subramaniam Nishanthan , Goonetilleke Sonali 
Published: November 2020

<p class="abstract">Patients with glucose-6-phosphate-dehydrogenase (G6PD) deficiency are prone to acute haemolytic crisis during perioperative period, precipitated by oxidative stress and certain medications, which are common concurrences during this period. Careful peri-operative planning, judicious use of medication and postoperative monitoring plays a pivotal role in preventing complications in these patients. Here, we report a successful case of general anaesthesia in a child with G6PD deficiency. </p>
Performance, Immune Response and Blood Biochemical Traits of Broiler Chickens Fed Graded Levels of Dietary Aflatoxin and Ochratoxin Combination
Authors: Tamilmani T. , Biswas Avishek , Mandal Asitbaran 
Published: November 2020

Background: Feed quality in terms of nutritional content is plays pivotal role in achieving desired production. Amongst the several factors which alter the quality of feed, inevitable fungal toxins that compromise the nutritive content quite often had taken attention posing serious health hazards on birds and humans as well. Moulds / Fungi are accomplished of reducing the nutritional value of feedstuffs as well as expanding some mycotoxins. Mycotoxin adulterated feed has adverse effects on poultry health and productivity. The present study aimed to study the effect of dietary supplementation of graded levels of dietary aflatoxin and ochratoxin combination on performance, immune response and blood biochemical traits of broiler chickens. Methods: A 42 days biological trial was conducted to study the effect of graded levels of aflatoxin B1 (AFB1) and ochratoxin (OTA) combination in the diet for production, immune response and blood biochemical parameters of broiler chickens. Day-old broiler chicks (n=240) were divided into five (5) treatment groups (T1: control; T2: T1 + 100 ppb AFB1+ 100 ppb OTA; T3: T1 + 100 ppb AFB1+ 200 ppb OTA; T4:T1 + 250 ppb AFB1+ 100 ppb OTA; and T5: T1 + 250 ppb AFB1+ 200 ppb OTA) and each treatment was fed to 6 replicated groups of 8 birds each. Result: Body weight gain (BWG) was significantly lower in T3, T4 and T5 group and feed intake (FI) in all the toxin supplemented groups was statistically similar but numerically higher compared to control group. Significantly lower feed conversion ratio (FCR) was recorded in 0-42 d at T1 and T2 group. The cell mediated immunity (CMI) and humoral immunity (haem-agglutination- HA titre) in higher doses of aflatoxin and ochratoxin combined fed group (T5) was lower (P less than 0.05). The liver damage enzymes such as alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were increased (P less than 0.05) in broilers fed on diet containing aflatoxin and ochratoxin combinations. Significant (P less than 0.05) reduction in serum uric acid and cholesterol level at T3, T4 and T5 dietary treated groups. No significant (P greater than 0.05) changes observed in total protein and aspartate aminotransferase (AST) concentration. Thus, it may be concluded that combination of Aflatoxin B1 (100 ppb) and ochratoxin A (100 ppb) in basal diet had no adverse effect on growth performance, immune response and blood biochemical parameters in broiler chicken.