bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of nitric oxide (NO)-responsive genes under hypoxia in tomato (Solanum lycopersicum L.) root
Authors: Safavi-Rizi Vajiheh , Herde Marco , Stöhr Christine 
Published: October 2020

AbstractFlooding periods, as one probable consequence of climate change, will lead more frequently to plant hypoxic stress. Hypoxia sensing and signaling in the root, as the first organ encountering low oxygen, is therefore crucial for plant survival under flooding. Nitric oxide has been shown to be one of the main players involved in hypoxia signaling through the regulation of ERFVII transcription factors stability. Using SNP as NO donor, we investigated the NO-responsive genes, which showed a significant response to hypoxia. We identified 395 genes being differentially regulated under both hypoxia and SNP-treatment. Among them, 251 genes showed up- or down-regulation under both conditions which were used for further biological analysis. Functional classification of these genes showed that they belong to different biological categories such as primary carbon and nitrogen metabolism (e.g. glycolysis, fermentation, protein and amino acid metabolism), nutrient and metabolites transport, redox homeostasis, hormone metabolism, regulation of transcription as well as response to biotic and abiotic stresses. Our data shed light on the NO-mediated gene expression modulation under hypoxia and provides potential targets playing a role in hypoxia tolerance. These genes are interesting candidates for further investigating their role in hypoxia signaling and survival.
Rapid identification of the invasive fall armyworm Spodoptera frugiperda (Lepidoptera, Noctuidae) using species-specific primers in multiplex PCR
Authors: Tsai Cheng-Lung , Chu I.-Hsuan , Chou Ming-Hsun , Chareonviriyaphap Theeraphap , Chiang Ming-Yao , Lin Po-An , Lu Kuang-Hui , Yeh Wen-Bin 
Published: October 2020

AbstractThe fall armyworm (FAW), Spodoptera frugiperda (Smith), is a major pest native to the Americas. A recent invasion of FAWs from Africa eastward to South Asia, the Indochina Peninsula, and mainland China has received much attention due to the considerable economic losses in agriculture. FAWs can rapidly colonise a new area, likely due to the wide range of host plants, good flying capability, and high egg production. Therefore, a convenient, quick, and accurate tool for FAW identification is urgently required to establish a FAW invasion management strategy. In this study, FAW-specific primers were designed to recognise FAWs on the basis of internal transcribed spacer 1 (ITS1). The results revealed the accurate FAW recognition of the three congeneric species and eight common corn lepidopteran pests, especially at their larval stage. Furthermore, species-specific primers have confirmed their efficacy by using 69 FAW specimens from Taiwan, Thailand, and the United States, with a 96% success rate, excluding 3 decayed specimens. By using the simple, reliable, and convenient FAW-specific primers, a pest management programme can be developed not only to reduce sequencing costs and experimental time from 2 days to 4 h, but eradicate the FAW as soon as it enters a new area.
The fabrication of 3D hierarchical flower-like δ-MnO2@COF nanocomposites for the efficient and ultra-fast removal of UO22+ ions from aqueous solution
Authors: Zhong Xin , Lu Zhipeng , Liang Wen , Guo Xiaojie , Hu Baowei 
Published: October 2020

3D flower-like δ-MnO2@TpPa-1 composites was constructed though the integration of δ-MnO2 nano-flowers with a covalent organic framework (TpPa-1) via ultrasonication process. δ-MnO2@TpPa-1 a promising adsorbent for spent-nuclear-fuel reprocessing.
An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
Authors: Moazeni-Roodi Abdolkarim , Sarabandi Sahel , Karami Shima , Hashemi Mohammad , Ghavami Saeid 
Published: October 2020

Abstract
Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs.
Several studies have focused on the association between FGFR4 polymorphisms and cancer development. This meta-analysis aimed to estimate the association between FGFR4 rs351855 (Gly388Arg), rs1966265 (Val10Ile), rs7708357, rs2011077, and rs376618 polymorphisms and cancer risk. Eligible studies were identified from electronic databases. All statistical analyses were achieved with the STATA 14.0 software. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to quantitatively estimate the association. Overall, no significant association was found among rs351855, rs2011077, and rs376618 polymorphisms with the risk of overall cancer. The rs1966265 polymorphism significantly decreased the risk of cancer in recessive (OR = 0.87, 95% CI = 0.78–0.97, P=0.009, TT vs CT+CC) genetic model. Whereas the rs7708357 polymorphism was positively associated with cancer risk in dominant (OR = 1.17, 95% CI = 1.02–1.36, P=0.028) genetic model. Stratified analysis revealed that rs351855 variant significantly increased the risk of prostate cancer in heterozygous (OR = 1.16, 95% CI = 1.02–1.32, P=0.025 AG vs GG), dominant (OR = 1.20, 95% CI = 1.06–1.35, P=0.004, AG+AA vs GG), and allele (OR = 1.22, 95% CI = 1.06–1.41, P=0.005, A vs G) genetic models.
In summary, the findings of this meta-analysis indicate that rs1966265, rs7708357, and rs351855 polymorphisms are correlated to cancer development. Further well-designed studies are necessary to draw more precise conclusions.
Chlorogenic acid ameliorated allergic rhinitis-related symptoms in mice by regulating Th17 cells
Authors: Shi Zhaohui , Jiang Weihong , Chen Xiaodong , Xu Min , Wang Jian , Lai Yubin , Zha Dingjun 
Published: October 2020

Abstract
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of nasal mucosa provoking T helper cell (Th) 17 response. Chlorogenic acid (CGA), one of the most abundant polyphenol compounds in various agricultural products, possesses antiviral, anti-inflammatory, and antibacterial properties. However, the effect of CGA on AR is unclear. Thus, our study explored the effect of CGA in modulating AR-related symptoms and immunoreaction, especially Th17 response. AR mice were induced by ovalbumin (OVA) administration and further treated with CGA or dexamethasone (Dex). The frequencies of rubbing and sneezing of AR mice were recorded. Histopathological analysis of nasal mucosa was conducted by Hematoxylin–Eosin and Periodic acid–Schiff stainings. The serum and nasal mucosa levels of OVA-immunoglobulin (Ig)E, interferon (IFN)-γ, retinoic acid-associated nuclear orphan receptor (ROR)-γt, and interleukin (IL)-17A were measured by enzyme-linked immunosorbent assay, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), or Western blot. The ratio of CD4+IL-17+Th17 cells to CD4+ T cells in peripheral blood of AR mice was assessed by flow cytometer. CGA diminished the frequencies of rubbing and sneezing of AR mice in a concentration-dependent manner. CGA attenuated histopathological abnormalities and decreased goblet cell number in nasal mucosa of AR mice. CGA decreased the serum levels of OVA-IgE, ROR-γt, and IL-17A, while increasing the serum level of IFN-γ in AR mice. Meanwhile, CGA decreased the ratio of CD4+IL-17+Th17 cells to CD4+T cells in peripheral blood and the mRNA and protein levels of IL-17A and ROR-γt in AR mice. CGA ameliorated AR-related symptoms in mice by regulating Th17 cells, which could be a candidate for the treatment of AR.
Blood prognostic predictors of treatment response for patients with papillary thyroid cancer
Authors: Liu Xiangxiang , Huang Zhongke , He Xianghui , Zheng Xiangqian , Jia Qiang , Tan Jian , Fan Yaguang , Lou Cen , Meng Zhaowei 
Published: October 2020

Abstract
Background: Papillary thyroid cancer (PTC) is a very common malignant disease with high morbidity. We needed some pretreatment indicators to help us predict prognosis and guide treatment. We conducted a study about some pretreatment prognostic indicators.
Methods: This clinical study recruited 705 postoperative PTC patients (211 males, 494 females). Clinical data before radioactive iodine (RAI) treatment were collected. Patients’ response to therapy were classified into two categories: ‘Good Prognosis Group’ (GPG) and ‘Poor Prognosis Group’ (PPG), according to ‘2015 American Thyroid Association Guidelines’. Differences of indicators between different prognosis groups were compared. Odds ratios (ORs) were calculated by univariate/multiple binary logistic regression models. Difference of body mass index (BMI) changes before and after RAI treatment between different prognosis groups was also compared.
Results: A total of 546 (77.45%) belonged to GPG, and 159 (22.55%) belonged to PPG. Platelet (PLT), neutrophil (NEUT), PLT subgroups, and combination of red blood cell distribution width (RDW) and BMI (COR-BMI) were different between two prognosis groups. The significance of the difference between the two groups of BMI disappeared after the Bonferroni correction. PLT and PLT subgroups had detrimental effects on the risk of PPG; T stage had a positive effect on the risk of PPG. PLT subgroup showed a detrimental effect on the risk of PPG when we included additional covariates.
Conclusions: We found that lower pretreatment PLT levels may indicate a poor prognosis for PTC. The relationship between platelet-derived growth factor (PDGF) and radiation sensitivity may be the key to this association.
Granulozytentransfusion: Update 2020
Authors: Doblinger Nina , Gruber Michael , Ahrens Norbert 
Published: October 2020

ZusammenfassungDie therapeutische Anwendung von Granulozytenkonzentraten erfolgt im klinischen Alltag im Gegensatz zu der anderer Blutprodukte nur selten und unregelmäßig. Der zurückhaltende Einsatz beruht unter anderem auf dem Fehlen einer breiten Evidenz, logistischen und wirtschaftlichen Problemen und dem Vorhandensein anderer potenter Therapieoptionen neutropener Infektionen. Dennoch gab es in den letzten Jahren neue wissenschaftliche Erkenntnisse nicht nur zu Physiologie und Pathophysiologie der Granulozyten, wie neu charakterisierten zellulären Verteidigungsstrategien oder deren Mitwirkung bei thrombotischen oder malignen Ereignissen, sondern auch zu deren therapeutischem Effekt. Dieser wird von einer Vielzahl an Parametern, wie der Art der Infektion, dem Transfusionszeitpunkt und der Dosis, beeinflusst. Das macht die Indikationsstellung zu einer komplexen Einzelfallentscheidung und es gilt, die heterogene Datenlage systematisch zusammenzufassen. Außerdem wurden die etablierten Indikationen neutropener bzw. neutropathischer Infektionen um experimentelle, mögliche neue Anwendungsgebiete wie die Mukositis oder Leukämiebehandlung erweitert. Die erfolgreiche Anwendung setzt eine geeignete, moderne Herstellungsweise voraus. Neben der Apherese, bei der eine relativ hohe Spenderbelastung unter anderem durch Nebenwirkungen von Mobilisationsregime und Sedimentationsbeschleunigern berücksichtigt werden muss, existieren weitere Verfahren wie die Gewinnung von Granulozyten aus Buffy Coats von Vollblutspenden. Diese versprechen eine Reduktion logistischer Probleme und unerwünschter Wirkungen auf den Spender. Unerwünschte Wirkungen bei Empfängern von Granulozytentransfusionen sollten nach wie vor berücksichtigt und gegen einen erhofften therapeutischen Effekt abgewogen werden.
Symmetry does not Indicate Recovery: Single-leg Hop Before and After a Lower Extremity Injury
Authors: Simon Janet E , Yom Jae , Grooms Dustin R 
Published: October 2020

AbstractCurrent recommendations for return-to-play decision-making involve comparison of the injured limb to the uninjured limb. However, the use of the uninjured limb as a comparison for hop testing lacks empirical evidence. Thus, the purpose of this study was to determine the effects of lower extremity injury on limb symmetry and performance on the single-leg hop for distance. Two-hundred thirty-six adolescent athletes completed the single-leg hop for distance before the beginning of the season (pre-injury). Forty-four adolescent athletes sustained a lower extremity injury (22 ankle and 12 knee) and missed at least three days of sports participation. All individuals had completed the single-leg hop for distance before the beginning of the season (pre-injury) and at discharge (post-injury). Injured limb single-leg hop for distance significantly decreased at return-to-play from pre-injury with a mean decrease of 48.9 centimeters; the uninjured limb also significantly decreased, with a mean decrease of 33.8 centimeters. Limb symmetry did not significantly change pre- to post-injury with a mean difference of 1.5%. Following a lower extremity injury, single-leg hop for distance performance degrades not only for the injured limb but also the uninjured limb. However, limb symmetry did not change following a lower extremity injury.
Acute Sigmoid Sinus Compromise Following Skull Base Procedures: Is a “Laissez-Faire” Approach Best?
Authors: Arnone Gregory D. , Kunigelis Katherine E. , Gurau Andrei , Coulter Ian , Thompson John , Youssef A. Samy 
Published: October 2020

Abstract
Objective Venous sinus compromise (VSC) of the sigmoid sinus can manifest as either venous sinus thrombosis, stenosis, or a combination of the two. It may occur following retro and presigmoid craniotomy, even in the absence of overt intraoperative sinus injury. Currently, the optimal management of VSC in the perioperative period is not well established. We report our incidence and management of VSC following skull base surgery around the sigmoid sinus.
Patients and Methods A retrospective chart review of all patients undergoing presigmoid, retrosigmoid, or combined approach by the senior author from 2014 to 2019 was performed.
Main Outcome Measures Charts were reviewed for patient demographics, surgical details, details of venous sinus compromise, and patient outcomes. Statistical analyses were performed using R 3.6.0 (R Project).
Results A 115 surgeries were found with a total of 13 cases of VSC (overall incidence of 11.3%). Nine cases exhibited thrombosis and four stenosis. There were no statistically significant differences between the groups with (group 1) or without (group 2) VSC. Operation on the side of the dominant sinus did not predispose to postoperative VSC. Five patients received antiplatelet medication in the perioperative period. There was no difference in outcomes in the group that did not receive antiplatelet medication versus those who did.
Conclusion Acute iatrogenic sigmoid sinus compromise can be managed expectantly. We believe that the treatment for each instance of VSC must be individualized, considering the symptoms of the patient, rather than applying a universal algorithm.
COVID-19 Pandemic in Women–Rheumatologist’s Perspective
Authors: Pinto Benzeeta , Roongta Rashmi 
Published: October 2020

AbstractCOVID-19 has caused unprecedented challenges to every field. Rheumatic diseases (RD) are more common in women compared with men. Patients with RD are predisposed to infections both because of their disease and immunosuppressive medication. The severity of COVID-19 in women is less as compared with men among the general population. It is not known if the risk is higher in women with RD compared with other women. Currently, published data of COVID-19 in RD suggests similar or mildly increased risk in patients with RD but sex disaggregated data is not available. In this article, we review the current evidence of COVID-19 in RD with an emphasis on women.
COVID-19 and Women: An Obstetrician’s Perspective
Authors: Tandon Pooja , Luthra Neeru , Aggarwal Ritika 
Published: October 2020

AbstractIn the era of COVID-19, pregnant patients have genuine concerns regarding their own health and the health of the unborn. It is difficult to provide standard protocols due to extremely limited data. The recommendations and guidelines are being frequently revised as we learn more about the disease.
Understanding the SARS-CoV-2 to Manage COVID-19
Authors: Karak Somdatta , Radha Vegesna 
Published: October 2020

AbstractThe entire scientific community have come together in the last eight months to understand the details of the novel SARS-CoV-2 virus that has caused the COVID-19 pandemic. We now have a fair idea of the main targets that should be looked into in depth to fight the virus. However, the data from different population groups on the different testing or treatment strategies is still largely lacking. Populations are diverse in terms of their genetics, nutritional status, microbiota, access to facilities, among many other factors. This article makes a case for looking into women-specific data on test results, response to disease management strategies, as well as mortality due to COVID-19, otherwise currently missing.
Volumetric Capnography in Pediatric Extracorporeal Membrane Oxygenation: A Case Series
Authors: Derespina Kim R. , Medar Shivanand S. , Aydin Scott I. , Kaushik Shubhi , Al-Subu Awni , Ofori-Amanfo George 
Published: October 2020

AbstractThe kinetics of carbon dioxide elimination (VCO2) may be used as a surrogate for pulmonary blood flow. As such, we can apply a novel use of volumetric capnography to assess hemodynamic stability in patients requiring extracorporeal membrane oxygenation (ECMO). We report our experience of pediatric patients requiring ECMO support who were monitored using volumetric capnography. We describe the use of VCO2 and its association with successful decannulation. This is a prospective observational study of pediatric patients requiring ECMO support at The Children's Hospital at Montefiore from 2017 to 2019. A Respironics NM3 monitor was applied to each patient. Demographics, hemodynamic data, blood gases, and VCO2 (mL/min) data were collected. Data were collected immediately prior to and after decannulation. Over the course of the study period, seven patients were included. Predecannulation VCO2 was higher among patients who were successfully decannulated than nonsurvivors (109 [35, 230] vs. 12.4 [7.6, 17.2] mL/min), though not statistically significant. Four patients (57%) survived without further mechanical support; two (29%) died, and one (14%) was decannulated to Berlin. Predecannulation VCO2 appears to correlate with hemodynamic stability following decannulation. This case series adds to the growing literature describing the use of volumetric capnography in critical care medicine, particularly pediatric patients requiring ECMO. Prospective studies are needed to further elucidate the use of volumetric capnography and optimal timing for ECMO decannulation.
Charged fluids encircling compact objects: force representations and conformal geometries
Authors: Kovář Jiří , Kojima Yasufumi , Slaný Petr , Stuchlík Zdeněk , Karas Vladimír 
Published: October 2020

Abstract
Charged fluids rotating around compact objects can form unique equilibrium structures when ambient large-scale electromagnetic fields combine with strong gravity. Equatorial as well as off-equatorial toroidal structures are among such figures of equilibrium with a direct relevance for astrophysics. To investigate their geometrical shapes and physical properties in the near-horizon regime, where effects of general relativity play a significant role, we commonly employ a scheme based on the energy–momentum conservation written in a standard representation. Here, we develop its interesting alternatives in terms of two covariant force representations, both based on a hypersurface projection of the energy–momentum conservation. In a proper hypersurface, space-like forces can be defined, following from a decomposition of the fluid four-acceleration. Each of the representations provides us with an insight into properties of the fluid flow, being well reflected in related conformal hypersurface geometries; we find behaviour of centrifugal forces directly related to geodesics of these conformal hypersurfaces and their embedding diagrams. We also reveal correspondence between the charged fluid flow world-lines from an ordinary spacetime, and world-lines determined by a charged test particles equation of motion in a conformal spacetime.
Photoionization of Xe 5s: angular distribution and Wigner time delay in the vicinity of the second Cooper minimum
Authors: Ganesan Aarthi , Banerjee Sourav , Deshmukh Pranawa C , Manson Steven T 
Published: October 2020

Abstract
The angular distribution and photoionization Wigner time delay of Xe 5s photoelectrons are studied in the region of the second Cooper minimum (SCM) using (i) the relativistic multiconfiguration Tamm–Dancoff approximation, (ii) the relativistic-random-phase approximation (RRPA) and (iii) the RRPA-with-relaxation to demonstrate how differing treatments of correlation, and the relativistic interactions, affect the results. The results of the three methods are compared with each other and with available experimental data. The comparison reveals the importance of electron correlations for which a multiconfiguration description of the initial state is essential. The spin-resolved and spin-averaged photoionization time delay results show important signatures in the region of the SCM in the Xe 5s photoionization cross-section.
Theoretical bases of hypothetical sphere-electrode detectors and practical near-sphere-electrode (semisphere-electrode and near-semisphere-electrode) detectors
Authors: Liu Manwen , Lu Shunmao , Li Zheng 
Published: October 2020

Abstract
In this work, one-dimensional (1D) modeling and simulations of the electric and weighting fields will be systematically carried out for hypothetical sphere-electrode detectors. Exact 1D solutions are obtained for electric and weighting fields in these detectors. Although it is impossible to realize hypothetical sphere-electrode detectors with current technologies, the theoretical work and results on them are good bases for their offspring—practical semi-sphere-electrodes (semisph-electrode) and near-semisph-electrode detectors. The great reduction in full depletion voltage and small capacitance in semisph-electrode and near-semisph-electrode detectors make them very good for applications in photon sciences (x-ray) and safeguard and homeland security (hard x-ray and gamma-ray). A practical novel structure of the three-dimensional (3D) trench electrode detector, namely a novel semisph-electrode silicon detector has been proposed as a practical example. The novel detector has a semispherical shell electrode created in a cuboidal unit cell. It will overcome the traditional 3D-electrode detector deficiencies in electrical performance such as the asymmetrical electric field distribution. Through a computer-aided design tool, 3D modeling and electrical characteristics, simulation of a semispherical electrode silicon detector has been obtained, such as electric field distributions, electron concentration distribution, and full depletion voltage