bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the effect of changing eligibility criteria for disability benefits on employment? A systematic review and meta-analysis of evidence from OECD countries
Authors: McHale Philip , Pennington Andy , Mustard Cameron , Mahood Quenby , Andersen Ingelise , Jensen Natasja Koitzsch , Burström Bo , Thielen Karsten , Harber-Aschan Lisa , McAllister Ashley , Whitehead Margaret , Barr Ben 
Published: December 2020

Background
Restrictions in the eligibility requirements for disability benefits have been introduced in many countries, on the assumption that this will increase work incentives for people with chronic illness and disabilities. Evidence to support this assumption is unclear, but there is a danger that removal of social protection without increased employment would increase the risk of poverty among disabled people. This paper presents a systematic review of the evidence on the employment effects of changes to eligibility criteria across OECD countries.

Methods
Systematic review of all empirical studies from OECD countries from 1990 to June 2018 investigating the effect of changes in eligibility requirements and income replacement level of disability benefits on the employment of disabled people. Studies were narratively synthesised, and meta-analysis was performed using meta-regression on all separate results. The systematic review protocol was registered with the Prospective Register for Systematic Reviews (Registration code: PROSPERO 2018 CRD42018103930).

Results
Seventeen studies met inclusion criteria from seven countries. Eight investigated an expansion of eligibility criteria and nine a restriction. There were 36 separate results included from the 17 studies. Fourteen examined an expansion of eligibility; six found significantly reduced employment, eight no significant effect and one increased employment. Twenty-two results examined a restriction in eligibility for benefits; three found significantly increased employment, 18 no significant effect and one reduced employment. Meta-regression of all studies produced a relative risk of employment of 1.06 (95% CI 0.999 to 1.014; I2 77%).

Conclusions
There was no firm evidence that changes in eligibility affected employment of disabled people. Restricting eligibility therefore has the potential to lead to a growing number of people out of employment with health problems who are not eligible for adequate social protection, increasing their risk of poverty. Policymakers and researchers need to address the lack of robust evidence for assessing the employment impact of these types of welfare reforms as well as the potential wider poverty impacts.
Retinal vascular metrics difference by comparison of two image acquisition modes using a novel OCT angiography prototype
Authors: Di Antonio Luca , Viggiano Pasquale , Ferro Giada , Toto Lisa , D’Aloisio Rossella , Porreca Annamaria , Di Nicola Marta , Mastropasqua Rodolfo 
Published: December 2020

Purpose
To assess the different impact of two enface OCTA image simultaneously acquired by means of a new prototype of Spectral-Domain Optical Coherence Tomography Angiography (SD-OCTA) on quantitative retinal vascular metrics.

Methods
In this prospective observational cross-sectional study 28 healthy subjects were enrolled. Macular (3x3 mm) OCTA images were acquired for all participants using Solix Fullrange OCT (Optovue Inc, Freemont CA, USA). The main outcome measurements were: Perfusion density (PD), vessel length density (VLD), and vessel diameter index (VDI) of both superficial capillary plexus (SCP) and deep capillary plexus (DCP), and choriocapillaris (CC) total flow-deficits area. Quantitative retinal vascular metrics were measured on binarized and skeletonized OCTA images by comparing not averaged and fast automated multiple averaged en face OCTA images.

Results
In both SCP and DCP, PD significantly increased (p = 0,005 and p = 0,030, respectively), and VLD significantly decreased (p<0,001 and p = 0,004, respectively), and VDI increased (p<0,001 and p = 0,068, respectively), and total CC flow deficits area significantly decreased (p<0,001) by averaging multiple OCTA images.

Conclusions
In this study, we found a significant difference of quantitative retinal metrics by comparing two different image acquisition modes using a novel and fully automated averaging OCTA system in young healthy subjects.
Case study of Argus in Togo: An SMS and web-based application to support public health surveillance, results from 2016 to 2019
Authors: Guerra José , Davi Kokou Mawule , Rafael Florentina Chipuila , Assane Hamadi , Imboua Lucile , Diallo Fatoumata Binta Tidiane , Tamekloe Tsidi Agbeko , Kuassi Aklagba Kuawo , Ouro-kavalah Farihétou , Tchaniley Ganiou , Ouro-Nile Nassirou , Nabeth Pierre 
Published: December 2020

IntroductionArgus is an open source electronic solution to facilitate the reporting and management of public health surveillance data. Its components include an Android-phone application, used by healthcare facilities to report results via SMS; and a central server located at the Ministry of Health, displaying aggregated results on a web platform for intermediate and central levels. This study describes the results of the use of Argus in two regions of Togo.MethodsArgus was used in 148 healthcare facilities from May 2016 to July 2018, expanding to 185 healthcare facilities from July 2018. Data from week 21 of 2016 to week 12 of 2019 was extracted from the Argus database and analysed. An assessment mission took place in August 2016 to collect users’ satisfaction, to estimate the concordance of the received data with the collected data, and to estimate the time required to report data with Argus.ResultsOverall completeness of data reporting was 76%, with 80% of reports from a given week being received before Tuesday 9PM. Concordance of data received from Argus and standard paper forms was 99.7%. Median time needed to send a report using Argus was 4 minutes. Overall completeness of data review at district, regional, and central levels were 89%, 68%, and 35% respectively. Implementation cost of Argus was 23 760 USD for 148 facilities.ConclusionsThe use of Argus in Togo enabled healthcare facilities to send weekly reports and alerts through SMS in a user-friendly, reliable and timely manner. Reengagement of surveillance officers at all levels, especially at the central level, enabled a dramatic increase in completeness and timeliness of data report and data review.
The Philosophy of Expressive Arts Therapy: Poiesis and the Therapeutic Imagination, Stephen K. Levine (2019)
Authors: Solarska Dorota K. 
Published: December 2020

Review of: The Philosophy of Expressive Arts Therapy: Poiesis and the Therapeutic Imagination, Stephen K. Levine (2019)
London: Jessica Kingsley Publishers, 176 pp.,
ISBN 978-1-78775-005-0, p/bk, £22.99
Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty
Authors: Wu Jian Xiang , Qing Jiang Hui , Yao Yao , Chen Dong Yang , Jiang Qing 
Published: December 2020

Abstract
Purpose: To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients. Methods: We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses.Results: A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR]: 1.067; p=0.003) and D-dimer (OR:1.331; p=0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively.Conclusion: Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.
COVID-19 effect on supply and demand of essential commodities using unsupervised learning method
Authors: Anitha P. , Patil Malini M. , Venkatapur Rekha B 
Published: December 2020

Abstract
The affliction caused by the Covid-19 Pandemic is diverse from other disasters seen so far. Supply chain industries are facing unique challenges in fulfilling the essential needs of the people. The objective of the paper is to analyse the supply and demand of essentials during pre-pandemic and post-pandemic lockdowns using machine learning algorithms. This helps for supply chain industries in forecasting and managing the supply and demand of essential stocks for the future. Data is analyzed using prediction algorithms to check the actual and predicted values. The clustering algorithm along with rolling mean is used for half-yearly data of 2019 and 2020 to identify the sales of different categories of essential commodities. This paper aims at applying intelligence in predicting various categories of sales by providing timely information for B2B Industries during the time of disasters.
Quantifying Covid19-Vaccine Location Strategies For Germany
Authors: Leithäuser Neele , Schneider Johanna , Johann Sebastian , Krumke Sven , Schmidt Eva , Streicher Manuel , Scholz Stefan 
Published: December 2020

Abstract
Background: Vaccines are an important tool to limit the health and economic damage of the Covid-19 pandemic. Several vaccine candidate already provided promising effectiveness data, but it is crucial for an effective vaccination campaign that people are willing and able to get vaccinated as soon as possible. Taking Germany as an example, we provide insights of using a mathematical approach for the planning and location of vaccination sites to optimally administer vaccines against Covid-19. Methods: We used mathematical programming for computing an optimal selection of vaccination sites out of a given set (i.e., university hospitals, health department related locations and general practices). Different patient-to-facility assignments and doctor-to-facility assignments and different constraints on the number of vaccinees per site or maximum travel time are used. Results: In order to minimize the barriers for people to get vaccinated, i.e., limit the one-way travel journey (airline distance) by around 35 km for 75% of the population (with a maximum of 70 km), around 80 well-positioned facilities can be enough. If only the 38 university hospitals are being used, the 75% distance increases to around 50 km (with a maximum of 145 km). Using all 400 health departments or all 56,000 general practices can decrease the journey length significantly, but comes at the price of more required staff and possibly wastage of only partially used vaccine containers. Conclusions: In the case of free assignments, the number of required physicians can in most scenarios be limited to 2 000, which is also the minimum with our assumptions. However, when travel distances for the patients are to be minimized, capacities of the facilities must be respected, or administrative assignments are prespecified, an increased number of physicians is unavoidable.
Transcriptome analysis identifies differentially expressed genes involved in the metabolic regulatory network of progenies from the cross of low phytic acid GmMIPS1 and GmIPK1 soybean mutants
Authors: Jin Hangxia , Yu Xiaomin , Yang Qinghua , Yuan Fengjie , Fu Xujun 
Published: December 2020

Abstract
Lowering the phytic acid (PA) content of crop seeds will be beneficial for improving their nutritional traits. Low phytic acid (lpa) crop lines carrying more than one independent mutated gene have been shown to exhibit more pronounced reductions of PA content than mutants with a single lpa mutated gene. But little is known about the link between PA pathway intermediates and downstream regulation following mutation of these genes in soybean. Here, we performed a comparative transcriptome analysis using an advanced-generation recombinant inbred line [2mlpa (mips1/ipk1)] with low PA and a sibling line with homozygous non-mutant alleles and normal PA [2MWT (MIPS1/IPK1)]. RNA sequencing revealed differential expression levels of numerous genes between seeds of 2mlpa and 2MWT at five developmental stages. A total of 7,945 differentially expressed genes were identified. 3316 DEGs were in 128 metabolic and signal transduction pathways and 4980 DEGs were classified into 345 function terms associated with biological processes. Genes associated with PA metabolism, photosynthesis, starch and sucrose metabolism, and defense mechanisms were related to low PA in 2mlpa soybean line. Among these, 36 genes were up/down-regulated in PA metabolic processes, with 22 possibly contributing to the low PA phenotype of 2mlpa. Most of the genes (81 of 117) associated with photosynthesis were down-regulated in 2mlpa at the late seed stage. Three genes involved in sucrose metabolism were up-regulated at the late seed stage, which might explain the high sucrose content of 2mlpa soybeans. Additionally, 604 genes related to defense mechanisms were differentially expressed between 2mlpa and 2MWT. In this research, the soybean mutant 2mlpa was found to not only exhibit low PA but also have changes in multiple metabolites and secondary metabolites. The results delineate the regulation of these metabolic events by 2mlpa. Many genes associated with PA metabolism would contribute to the drastic reduction of PA and moderate accumulation of InsP3-InsP5 in 2mlpa mutant. And other regulated genes found in photosynthesis, starch and sucrose metabolism, and defense mechanisms would give us more insight into the nutritional and agronomic performance of 2mlpa.
Prevalence and Genotype Distribution of Group A Rotavirus Circulating in Shanxi Province, China During 2015-2019
Authors: Zhao Lifeng , Shi Xiaohong , Meng Dequan , Guo Jiane , Li Yiping , Liang Lirong , Guo Xiaofang , Tao Ran , Zhang Xiaohua , Gao Ruihong , Gao Li , Wang Jitao 
Published: December 2020

Abstract
Background: Group A rotavirus (RVA), despite being a leading cause of gastroenteritis in infants and young children, is less studied in Shanxi Province, China. The current study was conducted to determine the prevalence and genetic characterization of RVA in hospitalized children under ten years old with the diagnosis of gastroenteritis in Shanxi Province, China. Methods: A hospital-based active surveillance of rotavirus gastroenteritis was conducted at Children’s Hospital of Shanxi from January 1, 2015, through December 31, 2019. Rotavirus was detected in stool samples by real-time quantitative reverse transcription PCR (qRT-PCR). G and P genotypes were determined by reverse transcription PCR (RT-PCR) and nucleotide sequencing. Results：A total of 961 archived stool specimens was examined, 183 (19.0%) were positive for RVA. The highest RVA-infection frequency (23.7%) was found among children aged 12–23 months, and the seasonal peak was in December. G9P[8] was most prevalent (76.0%), followed by G3P[8] (7.1 %), G2P[4] (3.3 %), G1P[8] (0.5 %) and G9P[4] (0.5 %).Conclusions: These results reported for the first time that RVA was one of the main causes of severe infectious gastroenteritis in children, and a high proportion of G9P[8] strains circulating in most areas of Shanxi Province. While the protective efficacy of the rotavirus vaccines has been demonstrated against G9P[8] strains, our results highlight that the dominant strains have not been effectively controlled in China.
A concept mobility device with multi-positional configurations and child-kind restraint for safe perioperative transfer and induction of anaesthesia in children with autistic spectrum disorder – a cross sectional study
Authors: Hee Hwan Ing , Lim Ying Ching , Tan Tracy , Wan Sharon , Wijeweera Olivia , Lee Sumin , Raghavan Kavitha 
Published: December 2020

Abstract
Background : Transfer into operating room, onto operating table and mask induction of anaesthesia are major challenge faced by children with Autistic Spectrum Disease (ASD). In a pilot study, parents observed that perioperative transfer becomes unsafe and difficult when children with ASD becomes uncooperative. Method : A CHILD-KIND CONCEPT mobility system comprising of multi-positioning seat configurations and restraining module was developed with inputs from multi-disciplinary healthcare professionals and parents with children with ASD. To appeal to children and motivate child-machine interaction, the seat configurations and restraining module are designed to take the form of child-friendly, non-threatening, fun and familiar items. The sitting configuration, sitting to supine transformation, the restraint modules resemble racing-car seat, reclining motion of a home massage chair, safety restraints found in airplanes and amusement rides respectively. Healthcare professionals (HCP) involved in the perioperative patient care, parents of ASD children and children (neurotypical and ASD) experience the use of the system in a non-clinical environment and participated in a survey study. The acceptance of its functionality (HCP, parents) for perioperative transfer and induction of anaesthesia, rating of the user experience and likes and dislikes of (parents and children) were obtained. Results: Thirty-two HCP, 30 parents and 23 children participated. Majority of parents and HCP opined the use of the system enables improvement in the management of perioperative movement (90.0% parents, 100% HCP), safe perioperative movement (86.7% parents, 96.9% HCP) and promotes ease of anaesthesia induction (76.7% parents, 90.6% HCP) for uncooperative combative ASD children. Overall, 90.6% HCP and 76.7% of parents would recommend its frequent use in their own practice and their ASD children respectively; 93.8% HCP and 86.7% parents would recommend it to other HCP and parents for use in other ASD children. Attractiveness and multi-functionality are attributes endorsed by parents and children. Children endorse its use for induction of anaesthesia (73.9%), dental chair (82.6%), intra-hospital transfer (95.7%). Conclusion : A child-kind mobility device that integrates appeal with functionality of restraint and multi-positional transformation has a potential to promote safe perioperative movement and ease of induction of anaesthesia in anxious uncooperative ASD children. Trial registration : None
Native and Invasive Ants Affect Floral Visits of Pollinating Honey Bees in Pumpkin Flowers (Cucurbita Maxima)
Authors: Unni Anjana , Mir Sajad , Rajesh T P , Ballullaya U Prashanth , Jose Thomas , Sinu Palatty Allesh 
Published: December 2020

Abstract
Global pollinator decline is a major concern. Several factors – climate change, land-use change, the decline of flowers, pesticide use, invasive species – have been suggested as the reasons. The effect of ants on flowers, despite being a potential reason, received less attention. The consequences of ants being attracted to nectar sources in plants vary depending upon factors like the position of the nectar source, the identity of ants, and other mutualists interacting with the plants. We studied the interaction between floral ants and pollinators in Cucurbita maxima and compared the competition exerted by native and invasive ants on the pollinator with the hypothesis that the invasive ants exacerbate more interference competition for pollinators than native ants. The pollinator’s choice, visitation rate and time spent/visit were assessed. Regardless of species and nativity ants negatively influenced all the pollinator visitation traits, such as visitation rate and duration spent on flowers. The invasive ants exerted a higher interference competition on the pollinators than native ants did. Ants despite performing pollination in flowers with generalist pollination syndrome, can be a threat for plant-pollinator mutualism in specialists like monoecious plants. A better understanding of factors influencing pollination will help in implementing better management practices.
Production, Purification, and Radiolabeling of the 203Pb/212Pb Theranostic Pair
Authors: McNeil Brooke L , Robertson Andrew K. H. , Fu Winnie , Yang Hua , Hoehr Cornelia , Ramogida Caterina Fortunata , Schaffer Paul 
Published: December 2020

Abstract
Background: Lead-212 (212Pb, t1/2 = 10.6 h) and lead-203 (203Pb, t1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) and single-photon emission computed tomography (SPECT), respectively. At TRIUMF we have produced both 203Pb and 212Pb using TRIUMF’s TR13 (13 MeV) and 500 MeV cyclotrons, and subsequently purified and evaluated both radioisotopes using a series of pyridine-modified DOTA analogues in comparison to the commercially available chelates DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and TCMC (1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbomoylmethyl)cyclododecane).Results: Proton irradiation (12.8 MeV) of natural and enriched thalium-203 (203Tl) targets gave 203Pb saturation yields of 134 ± 25 and 483 ± 3 MBq/μA, respectively. Thorium-228 (228Th, t1/2 = 1.9 y), a by-product of 232Th proton spallation on TRIUMF’s main 500 MeV beamline (beamline 1A, BL1A), was recovered to build a 228Th/212Pb generator with the ability to deliver up to 9-10 MBq of 212Pb daily. Both lead isotopes were purified via solid phase extraction chromatography (Pb resin), and isolated in an acetate form ([203/212Pb]Pb(OAc)2) suitable for direct radiolabeling of chelators and bioconjugates. A series of cyclen-based chelators (herein referred to as DOTA-1Py, -2Py, and -3Py) along with established chelates DOTA and TCMC were evaluated for their ability to complex both 203Pb and 212Pb. All chelates incorporated 212Pb/203Pb efficiently, with higher radiolabeling yields observed for the 212Pb-complexes. Conclusion: The production of 203Pb and 212Pb was established using TRIUMF 13 MeV and 500 MeV cyclotrons, respectively. Both production methods provided radiometals suitable for subsequent radiolabeling reactions using known and novel chelates. Furthermore, the novel chelate DOTA-3Py may be a good candidate for biomolecule conjugation and further theranostic 212Pb/203Pb studies.
Role of Gender Participation in Household Energy Technology to Achieve Sustainability: A case of Kathmandu
Authors: Shrestha Bindu , Tiwari Sudarshan , Bajracharya Sushil , keitsch Martina 
Published: December 2020

Abstract
Introduction: Sustainability has become a global topic for quality of life on energy efficiency consideration. This study aims to evaluate the sustainability level of household energy consumption from the gender lens.Material and Methods: 623 households above the age of 18 years were surveyed on energy use behavior in terms of economic, social, and environmental aspects to evaluate sustainability level. The study was based on interviews, observation, and air quality tests. CO2 of the urban kitchen was tested in 12 households measured in ppm.Results: The study revealed that the lower-income group uses a larger share of their monthly income for household energy needs having unclean cooking fuel. The use of electrical appliances and income has a moderate correlation (r=.48). Social indicators demonstrate that female participation in energy decisions is higher only in female-headed and nuclear families. Environmental indicators exhibit that Kathmandu urban households are eager to use electric cooking, but they have insufficient knowledge, information, and less affordability for new technology. It resulted that the city's sustainability level is still low (56 scores) from a gender perspective.Conclusion: The study concluded that innovative technical interventions are essential to combine with the subsidy policy to reduce inequality between low and high energy household shares. The increased women’s participation in energy technology supports getting a clean environment reducing the nation's financial burden of importing fuel.