bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Xenografts in Trauma and Orthopaedics (Analytical Review)
Authors: Stogov M. V. , Smolentsev D. V. , Kireeva E. A. 
Published: March 2020

Purpose of the analytical review — to evaluate the application experience of bone xenografts in trauma and orthopaedics surgery. Methods. Data search was performed in the electronic databases of PubMed and eLIBRARY with depth of 20 years. Results. The authors identified 13 papers which described the application experience of bone xenografts in trauma surgery and orthopaedics. The highest efficiency (from 92 to 100%) was reported for cases of xenografts use to replace defects in intraarticular fractures and revision arthroplasty. Unsatisfactory outcomes were related to cases with no integration and graft rejection. The least efficiency (from 41,9 to 46,1%) was reported in reconstructive foot surgery. No effect of bone xenografts was observed for replacement of defects in cases of pseudoarthrosis. The most frequent complication was graft material infection. The summarized literature data provided the calculated share of complications following xenograft use of 7,53% (18 out of 239 cases, CI 5-95%, 4,53-11,21). Two areas were identified for improvement of technical and biological properties of bone xenografts: 1. Modification of original xeno-matrix (enhancement of purification technique, alteration of structure of chemical composition of the bone matrix); 2. Augmentation of matrix volume by additional elements (biologically active agents, stem cells). It’s noted that demand for xenografts in traumatology and orthopaedics can increase after refining and expanding the indications for clinical use. Conclusion. Bone xenografts used in the modern trauma surgery and orthopaedics to replace bone defects in revision arthroplasty as well as in certain fracture types. Such material is relatively safe and its ability to be modified allows to improve its biological properties.
Appropriateness of Overridden Alerts in Computerized Physician Order Entry: Systematic Review
Authors: Poly Tahmina Nasrin , Islam Md.Mohaimenul , Yang Hsuan-Chia , Li Yu-Chuan (Jack) 
Published: March 2020

Background
The clinical decision support system (CDSS) has become an indispensable tool for reducing medication errors and adverse drug events. However, numerous studies have reported that CDSS alerts are often overridden. The increase in override rates has raised questions about the appropriateness of CDSS application along with concerns about patient safety and quality of care.

Objective
The aim of this study was to conduct a systematic review to examine the override rate, the reasons for the alert override at the time of prescribing, and evaluate the appropriateness of overrides.

Methods
We searched electronic databases, including Google Scholar, PubMed, Embase, Scopus, and Web of Science, without language restrictions between January 1, 2000 and March 31, 2019. Two authors independently extracted data and crosschecked the extraction to avoid errors. The quality of the included studies was examined following Cochrane guidelines.

Results
We included 23 articles in our systematic review. The range of average override alerts was 46.2%-96.2%. An average of 29.4%-100% of the overrides alerts were classified as appropriate, and the rate of appropriateness varied according to the alert type (drug-allergy interaction 63.4%-100%, drug-drug interaction 0%-95%, dose 43.9%-88.8%, geriatric 14.3%-57%, renal 27%-87.5%). The interrater reliability for the assessment of override alerts appropriateness was excellent (kappa=0.79-0.97). The most common reasons given for the override were “will monitor” and “patients have tolerated before.”

Conclusions
The findings of our study show that alert override rates are high, and certain categories of overrides such as drug-drug interaction, renal, and geriatric were classified as inappropriate. Nevertheless, large proportions of drug duplication, drug-allergy, and formulary alerts were appropriate, suggesting that these groups of alerts can be primary targets to revise and update the system for reducing alert fatigue. Future efforts should also focus on optimizing alert types, providing clear information, and explaining the rationale of the alert so that essential alerts are not inappropriately overridden.
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression and/or Generalized Anxiety Disorder: Protocol for a Phase 1, Open-Label Study
Authors: Chinna Meyyappan Arthi , Milev Roumen 
Published: March 2020

Background
The bidirectional signaling between the gut microbiota and the brain, known as the gut-brain axis, is being heavily explored in current neuropsychiatric research. Analyses of the human gut microbiota have shown considerable individual variability in bacterial content, which is hypothesized to influence brain function, and potentially mood and anxiety symptoms, through gut-brain axis communication. Preclinical and clinical research examining these effects suggests that fecal microbiota transplant (FMT) may aid in improving the severity of depression and anxiety symptoms by recolonizing the gastrointestinal (GI) tract with healthy bacteria. The microbial ecosystem therapeutic (ie, microbial ecosystem therapeutic-2 [MET-2]) used in this study is an alternative treatment to FMT, which comprises 40 different strains of gut bacteria from a healthy donor.

Objective
The primary objective of this study is to assess subjective changes in mood and anxiety symptoms before, during, and after administration of MET-2. The secondary objectives of this study are to assess the changes in metabolic functioning and the level of repopulation of healthy gut bacteria, the safety and tolerability of MET-2, and the effects of early stress on biomarkers of depression/anxiety and the response to treatment.

Methods
Adults experiencing depressive or anxiety symptoms will be recruited from the Kingston area. These participants will orally consume an encapsulated MET-2 once daily—containing 40 strains of purified and laboratory-grown bacteria from a single healthy donor—for 8 weeks, followed by a 2-week treatment-free follow-up period. Participants will undergo a series of clinical assessments measuring mood, anxiety, and GI symptoms using validated clinical scales and questionnaires. Molecular data will be collected from blood and fecal samples to assess metabolic changes, neurotransmitter levels, inflammatory markers, and the level of engraftment of the fecal samples that may predict outcomes in depression or anxiety.

Results
Given the association between the gut bacteria and the risk factors of depression, we expect to observe an improvement in the severity of depressive and anxiety symptoms following treatment, and we expect that this improvement is mediated by the recolonization of the GI tract with healthy bacteria. The recruitment for this study has been completed, and the data obtained are currently being analyzed.

Conclusions
This is the first time MET-2 is being tested in psychiatric indications, specifically depression and anxiety. As such, this may be the first study to show the potential effects of microbial therapy in alleviating psychiatric symptoms as well as its safety and tolerability.

International Registered Report Identifier (IRRID)
DERR1-10.2196/17223
Digital Phenotyping Self-Monitoring Behaviors for Individuals With Type 2 Diabetes Mellitus: Observational Study Using Latent Class Growth Analysis
Authors: Yang Qing , Hatch Daniel , Crowley Matthew J , Lewinski Allison A , Vaughn Jacqueline , Steinberg Dori , Vorderstrasse Allison , Jiang Meilin , Shaw Ryan J 
Published: March 2020

Background
Sustained self-monitoring and self-management behaviors are crucial to maintain optimal health for individuals with type 2 diabetes mellitus (T2DM). As smartphones and mobile health (mHealth) devices become widely available, self-monitoring using mHealth devices is an appealing strategy in support of successful self-management of T2DM. However, research indicates that engagement with mHealth devices decreases over time. Thus, it is important to understand engagement trajectories to provide varying levels of support that can improve self-monitoring and self-management behaviors.

Objective
The aims of this study were to develop (1) digital phenotypes of the self-monitoring behaviors of patients with T2DM based on their engagement trajectory of using multiple mHealth devices, and (2) assess the association of individual digital phenotypes of self-monitoring behaviors with baseline demographic and clinical characteristics.

Methods
This longitudinal observational feasibility study included 60 participants with T2DM who were instructed to monitor their weight, blood glucose, and physical activity using a wireless weight scale, phone-tethered glucometer, and accelerometer, respectively, over 6 months. We used latent class growth analysis (LCGA) with multitrajectory modeling to associate the digital phenotypes of participants’ self-monitoring behaviors based on their engagement trajectories with multiple mHealth devices. Associations between individual characteristics and digital phenotypes on participants’ self-monitoring behavior were assessed by analysis of variance or the Chi square test.

Results
The engagement with accelerometers to monitor daily physical activities was consistently high for all participants over time. Three distinct digital phenotypes were identified based on participants’ engagement with the wireless weight scale and glucometer: (1) low and waning engagement group (24/60, 40%), (2) medium engagement group (20/60, 33%), and (3) consistently high engagement group (16/60, 27%). Participants that were younger, female, nonwhite, had a low income, and with a higher baseline hemoglobin A1c level were more likely to be in the low and waning engagement group.

Conclusions
We demonstrated how to digitally phenotype individuals’ self-monitoring behavior based on their engagement trajectory with multiple mHealth devices. Distinct self-monitoring behavior groups were identified. Individual demographic and clinical characteristics were associated with different self-monitoring behavior groups. Future research should identify methods to provide tailored support for people with T2DM to help them better monitor and manage their condition.

International Registered Report Identifier (IRRID)
RR2-10.2196/13517
PENGARUH UMR , KURS DAN PENDUDUK JIWA TERHADAP TINGKAT PENGANGGURAN SUMATERA UTARA PERIODE 2001-2017
Authors: Yuni Revita 
Published: March 2020

Penelitian ini bertujuan untuk mengetahui pengaruh upah minimum, penduduk jiwa dan kurs terhadap tingkat pengangguran di Indonesia pada periode 2001-2017. Pendekatan penelitian yang digunakan adalah pendekatan penelitian korelasi, sedangkan metode analisis yang digunakan adalah regresi data berganda. Obyek yang digunakan dalam penelitian ini adalah provinsi Sumatera Utara di Indonesia. Hasil penelitian menunjukan bahwa ketiga variabel tidak memiliki pengaruh positif dan signifikan terhadap tingkat pengangguran.. Dengan kata lain, jika upah minimum regional nilainya naik, maka tidak akan menaikan jumlah tingkat pengangguran secara signifikan. Kurs memiliki pengaruh negatif dan signifikan terhadap tingkat pengangguran. Dengan kata lain, jika kurs nilainya naik, maka akan menurunkan jumlah tingkat pengangguran. Kata Kunci : Pengangguran, , Upah Minimum Regional, Nilai tukar
Novel use of an activity monitor to model jumping behaviors in cats
Authors: Sharon Kate P. , Thompson Caryn M. , Lascelles B. Duncan X. , Parrish Rudolph S. 
Published: March 2020

Abstract

OBJECTIVE
To develop methods to identify and characterize activity monitor (AM) data signatures for jumps performed by cats.

ANIMALS
13 healthy, client-owned cats without evidence of osteoarthritis or degenerative joint disease.

PROCEDURES
Each cat was fitted with the same AM, individually placed in an observation room, then simultaneously recorded by 3 video cameras during the observation period (5 to 8 hours). Each cat was encouraged to jump up (JU), jump down (JD), and jump across (JA) during the observation period. Output from the AM was manually annotated for jumping events, each of which was characterized by functional data analysis yielding relevant coefficients. The coefficients were then used in linear discriminant analysis to differentiate recorded jumps as JUs, JDs, or JAs. To assess the model's ability to distinguish among the 3 jump types, a leave-one-out cross-validation method was used, and the misclassification error rate of the overall categorization of the model was calculated.

RESULTS
Of 731 jumping events, 29 were misclassified. Overall, the mean misclassification error rate per cat was 5.4% (range, 0% to 12.5%), conversely indicating a correct classification rate per cat of 94.6%.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that the model was successful in correctly identifying JUs, JDs, and JAs in healthy cats. With advancements in AM technology and data processing, there is potential for the model to be applied in clinical settings as a means to obtain objective outcome measures.
Glomerular filtration rate determined by measuring serum clearance of a single dose of inulin and serum symmetric dimethylarginine concentration in clinically normal cheetahs (Acinonyx jubatus)
Authors: Sanchez Carlos R. , Hayek Lee-Ann C. , Carlin Ellen P. , Brown Scott A. , Citino Scott , Marker Laurie , Jones Krista L. , Murray Suzan 
Published: March 2020

Abstract

OBJECTIVE
To establish a reference interval for glomerular filtration rate (GFR) determined by measuring serum clearance of a single IV dose of inulin in clinically normal cheetahs (Acinonyx jubatus) and compare serum symmetric dimethylarginine (SDMA) concentration in cheetahs with GFR.

ANIMALS
33 cheetahs housed at 3 institutions.

PROCEDURES
A single bolus of inulin (3,000 mg/m2) was administered IV, and 5 serial blood samples were collected and analyzed for serum inulin concentration with the anthrone technique. The GFR was estimated with a modified slope-intercept method for the slow component of the serum concentration-versus-time curve. Blood urea nitrogen and serum creatinine concentrations were measured in samples obtained immediately prior to inulin administration, and serum SDMA concentration was measured in stored samples.

RESULTS
Mean ± SD measured GFR was 1.58 ± 0.39 mL/min/kg, and the calculated reference interval was 0.84 to 2.37 mL/min/kg. There were significant negative correlations between GFR and serum creatinine concentration (r = −0.499), BUN concentration (r = −0.592), and age (r = −0.463). Serum SDMA concentration was not significantly correlated with GFR (r = 0.385), BUN concentration (r = −0.281), or serum creatinine concentration (r = 0.165).

CONCLUSIONS AND CLINICAL RELEVANCE
A reference interval for GFR in clinically normal cheetahs was obtained. Further evaluation of animals with renal disease is needed to determine whether measuring serum clearance of a single IV dose of inulin is a reliable diagnostic test for early detection of renal disease in cheetahs.
Revisions and Revisionisms in H.O. Meisner’s Modern Diplomatics of Files: An Essay in the Historical Anthropology of Bureaucratic Mediocracy
Authors: Wimmer Mario 
Published: March 2020

Abstract
In this essay I lay out an argument about the scholarship on the emergent rationality of files. Looking at the case of Heinrich Otto Meisner’s groundbreaking modern diplomatics of files and the conditions and possibilities that shaped the argument of his work both practically and politically, I suggest a model for the analysis of bureaucratic mediocracy in historical perspective. I argue for an historical anthropology that acknowledges the epistemic violence and politics of inclusion and exclusion in bureaucracy in order to arrive at an historical anthropology of reason that does not deny, but instead attempts to think through its unequal terms.
Asking Appropriate Questions, Reconsidering Research Agendas: Moving between London and Lusaka, in- and outside the Archive
Authors: Rüther Kirsten 
Published: March 2020

Abstract
This article deals with the question of how issues of late colonial housing in Zambia were passed through various segments and between various layers of an encompassing colonial administration. It is equally about the question how the researcher retraces that process of administering housing. The main argument is that a discourse clad in techno-scientific language in the colonial metropole assumed undertones of development and morality in the colony. The text pays particular attention to the bureaucratic individuals seizing opportunities – often in cooperation with one or two colleagues, or across racial dividing lines. Furthermore, the contribution ponders on the significance of the researcher's encounters with both archival staff in London and Lusaka as through these interactions initial research agendas become redirected and adjusted.
Pain’s Records: An Anthropological Account of Medical Documentation in South Asia
Authors: Bhangu Shagufta Kaur 
Published: March 2020

Abstract
The Institute for Pain Management in Kolkata, like other modern institutions, is organised by record keeping. But the central object of its records, pain, presents a fundamental challenge to documentation. Pain is marked by a non-relational attribute that limits attempts to communicate and express it. I follow the institutional life of one patient and his struggles with health care through his documentary productions. As the paper traces clinical management of his pain, a proliferation of medical records is revealed. The forms of this documentary multiplicity, its materiality and how it enacts pain’s therapeutics are described. The challenge of pain’s communication is addressed by translating a body in pain constituted through artefacts and intersubjective relationships to a body in pain that exists almost entirely on paper. This translation proves efficacious in the eyes of doctors and patients, and is critical to the management of chronic pain in Kolkata.
Wieder gelesen: Cornelia Vismann, »Akten« (2000)
Authors: Lüttge Felix 
Published: March 2020

Abstract
This Relektüre revisits Cornelia Vismann’s book Files: Law and Media Technology almost 20 years after its initial publication. Situating the book in the media historical and intellectual constellations in which it originally appeared, this article provides an overview of Vismann’s approach to legal and administrative history and sheds light on the book’s reception.
On the existence of periodic solution and the transition to chaos of Rayleigh-Duffing equation with application of gyro dynamic
Authors: El-Borhamy Mohamed , Mosalam Nahla 
Published: March 2020

Abstract
In this article, the study of qualitative properties of a special type of non-autonomous nonlinear second order ordinary differential equations containing Rayleigh damping and generalized Duffing functions is considered. General conditions for the stability and periodicity of solutions are deduced via fixed point theorems and the Lyapunov function method. A gyro dynamic application represented by the motion of axi-symmetric gyro mounted on a sinusoidal vibrating base is analyzed by the interpretation of its dynamical motion in terms of Euler’s angles via the deduced theoretical results. Moreover, the existence of homoclinic bifurcation and the transition to chaotic behaviour of the gyro motion in terms of main gyro parameters are proved. Numerical verifications of theoretical results are also considered.
Occupational burnout in nurses: a concept analysis†
Authors: Zeng Jun-Fang , Xiao Ai-Xiang , Ye Jun-Rong , Cai Hong-Tao , Li Wei-Ming , Xia Zhi-Chun , Li Si-Jue , Lin Jian-Kui 
Published: March 2020

Abstract

Objective
This paper aims to clarify the concept of occupational burnout (OB) as well as develop appropriate methods to relieve or prevent OB in the nursing profession.

Methods
Walker and Avant’s eight-step approach of concept analysis was applied.

Results
OB was defined as a chronic form of work-related stress. Accurately, it was characterized by emotional exhaustion, depersonalization/cynicism, and reduced personal accomplishment/inefficacy. Antecedents of burnout included (a) demographic characteristics; (b) chronic exposure to work-related stressors; (c) quantitative and qualitative job demands; (d) lack of job resources; and (e) personality traits. Consequences involved (a) individual’s unfavorable quality of life; (b) negative impact on the organization; and (c) poor services quality. Although the Maslach Burnout Inventory (MBI) is perceived as an ideal tool to measure burnout and hence, it is used worldwide, whether this instrument fits to measure this concept for nurses has still not yet been verified and thus further research is needed.

Conclusions
By proposing a comprehensive definition of the concept, this analysis contributes to recognition of the process of OB of nurses. All nurses are vulnerable to OB. Hence, burnout in nursing needs to be recognized as a critical factor in the delivery of safe patient care. It proposes that the prevention of OB would be achieved through team communication training, mindfulness group, education, etc.
Chinese nurses’ perceived impact of international educational experiences and cultural beliefs following a 1-year study abroad program: an exploratory study
Authors: Wolf Debra M. , Wu Hui-Xin , Spadaro Kathleen , Hunker Diane F. 
Published: March 2020

Abstract

Objectives
To examine the perceived impact of international educational experiences and cultural beliefs before and after completing a 1-year Masters of Science in Nursing program.

Methods
An exploratory study was conducted among Chinese nurses studying abroad in a private medium-sized university in the United States. The 27-item electronic pre-survey was administered within 1 week of starting the program and the post-survey was administered 1 year later at the completion of the program.

Results
Majority of participants (n = 25) were female, 23–36 years of age. Findings revealed that the perceived impact of international educational experiences assessed at the start of the program was similar to the perceived impact measured at the end of the 1-year program, suggesting that the students learned and experienced what they anticipated. There was a significant impact on cultural beliefs from the start of the program compared with the end of the program suggesting that a 1-year study abroad program does influence cultural beliefs.

Conclusions
Understanding what is important to provide in a study abroad program and providing the educational experiences identified by students as impactful are avenues to help host universities best develop their programs. Findings suggested that the 1-year program can influence foreign students’ cultural beliefs, yet the professional and personal impact of this change warrants further study.