bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
Authors: Romdhoni Achmad Chusnu , Aulia Riskha , Utaminingtyas Ririn Prasetyo , Suharjono  , Alderman Christopher Paul 
Published: January 2020

Abstract

Background
Nasopharyngeal cancer (NPC) is the most common neck/head cancer occurring in Indonesia and is the fourth most malignant after breast cancer, cervical cancer, and lung cancer. It is known that the cost of chemotherapy may not be separated from quality of life (QoL) to reflect the success of therapy, especially in cancer patients. Thus, studies on the correlation between chemotherapy cost and the QoL in NPC patients are needed.

Methods
The participants were recruited by a consecutive sampling method. All patients diagnosed with NPC using a paclitaxel-cisplatin chemotherapy regimen in August–March 2019 for first until the third chemotherapy cycle were assessed for their the chemotherapy cost and QoL before the first chemotherapy cycle and after the third cycle using the EORTC QLQ-C30 questionnaire. Chemotherapy cost and QoL were analyzed using SPSS version 20 to find out the correlation.

Results
Data from 26 patients showed a notable increase in the QoL after the third chemotherapy cycle. Thus, there was a relationship between chemotherapy cost and QoL in NPC patients. The total cost of chemotherapy increased with the increase in cycles of chemotherapy. We further analyzed the correlation between QoL and the cost of chemotherapy. We found that there was a correlation between the cost and the aspects of global health status, the QoL.

Conclusions
It is concluded that chemotherapy that is followed by the increase in cost in chemotherapy improves the QoL.
The multiscale enhancement of mechanical properties of 3D MWK composites via poly(oxypropylene) diamines and GO nanoparticles
Authors: Zuo Hong-mei , Li Dian-sen , Hui David , Jiang Lei 
Published: January 2020

AbstractInterfacial bonding between the fibers and matrix plays a large role in mechanical properties of composites. In this paper, poly(oxypropylene) diamines (D400) and graphene oxide (GO) nanoparticles were grafted on the desized 3D multi axial warp knitted (MWK) glass fiber (GF) fabrics. The surface morphology and functional groups of modified glass fibers were characterized by scanning electron microscopy (SEM) and fourier transform infrared spectra (FT-IR). Out-of-plane compression properties and the failure mechanisms of composites at different temperature were tested and analyzed. The results revealed that GO nanoparticles were successfully grafted on fibers under the synergistic effect of D400. In addition, D400-GO-grafted composite possessed the highest mechanical properties than desized composite and GO-grafted composite. Their strength and modulus were improved by 10.16%, 10.06%, 8.92%, 8.75%, 7.76% and 40.38%, 32.74%, 29.85%, 26.98%, 25.16% compared to those of desized composites at 30∘C, 60∘C, 90∘C, 120∘C, 150∘C, respectively. The damage to D400-GO-grafted composite was yarns fracture accompanied with fibers breakage, matrix cracking, interface debonding. At higher temperature, interlayer slipping with matrix plasticization was the main failure mode.
A novel 4 camera multi-stereo tracking system for application in surgical navigation systems
Authors: Gieseler Oliver , Roth Hubert , Wahrburg Jürgen 
Published: January 2020

Abstract
In this paper, we present a novel 4 camera stereo system for application as optical tracking component in navigation systems in computer-assisted surgery. This shall replace a common stereo camera system in several applications. The objective is to provide a tracking component consisting of four single industrial cameras. The system can be built up flexibly in the operating room e. g. at the operating room lamp. The concept is characterized by independent, arbitrary camera mounting poses and demands easy on-site calibration procedures of the camera setup. Following a short introduction describing the environment, motivation and advantages of the new camera system, a simulation of the camera setup and arrangement is depicted in Section 2. From this, we gather important information and parameters for the hardware setup, which is described in Section 3. Section 4 includes the calibration of the cameras. Here, we illustrate the background of camera model and applied calibration procedures, a comparison of calibration results obtained with different calibration programs and a new concept for fast and easy extrinsic calibration.
Complementary Control over Habits and Behavioral Vigor by Phasic Activity in the Dorsolateral Striatum
Authors: Crego Adam C. G. , Štoček Fabián , Marchuk Alec G. , Carmichael James E. , van der Meer Matthijs A. A. , Smith Kyle S. 
Published: January 2020

Despite clear evidence linking the basal ganglia to the control of outcome insensitivity (i.e., habit) and behavioral vigor (i.e., its behavioral speed/fluidity), it remains unclear whether or how these functions relate to one another. Here, using male Long–Evans rats in response-based and cue-based maze-running tasks, we demonstrate that phasic dorsolateral striatum (DLS) activity occurring at the onset of a learned behavior regulates how vigorous and habitual it is. In a response-based task, brief optogenetic excitation at the onset of runs decreased run duration and the occurrence of deliberative behaviors, whereas midrun stimulation carried little effect. Outcome devaluation showed these runs to be habitual. DLS inhibition at run start did not produce robust effects on behavior until after outcome devaluation. At that time, when the DLS was plausibly most critically required for performance (i.e., habitual), inhibition reduced performance vigor measures and caused a dramatic loss of habitual responding (i.e., animals quit the task). In a second cue-based “beacon” task requiring behavior initiation at the start of the run and again in the middle of the run, DLS excitation at both time points could improve the vigor of runs. Postdevaluation testing showed behavior on the beacon task to be habitual as well. This pattern of results suggests that one role for phasic DLS activity at behavior initiation is to promote the execution of the behavior in a vigorous and habitual fashion by a diverse set of measures.SIGNIFICANCE STATEMENTOur research expands the literature twofold. First, we find that features of a habitual behavior that are typically studied separately (i.e., maze response performance, deliberation movements, running vigor, and outcome insensitivity) are quite closely linked together. Second, efforts have been made to understand “what” the dorsolateral striatum (DLS) does for habitual behavior, and our research provides a key set of results showing “when” it is important (i.e., at behavior initiation). By showing such dramatic control over habits by DLS activity in a phasic time window, plausible real-world applications could involve more informed DLS perturbations to curb intractably problematic habits.
The Origin of Physiological Local mGluR1 Supralinear Ca2+Signals in Cerebellar Purkinje Neurons
Authors: Ait Ouares Karima , Canepari Marco 
Published: January 2020

In mouse cerebellar Purkinje neurons (PNs), the climbing fiber (CF) input provides a signal to parallel fiber (PF) synapses, triggering PF synaptic plasticity. This signal is given by supralinear Ca2+transients, associated with the CF synaptic potential and colocalized with the PF Ca2+influx, occurring only when PF activity precedes the CF input. Here, we unravel the biophysical determinants of supralinear Ca2+signals associated with paired PF-CF synaptic activity. We used membrane potential (Vm) and Ca2+imaging to investigate the local CF-associated Ca2+influx following a train of PF synaptic potentials in two cases: (1) when the dendriticVmis hyperpolarized below the restingVm, and (2) when the dendriticVmis at rest. We found that supralinear Ca2+signals are mediated by type-1 metabotropic glutamate receptors (mGluR1s) when the CF input is delayed by 100–150 ms from the first PF input in both cases. When the dendrite is hyperpolarized only, however, mGluR1s boost neighboring T-type channels, providing a mechanism for local coincident detection of PF-CF activity. The resulting Ca2+elevation is locally amplified by saturation of endogenous Ca2+buffers produced by the PF-associated Ca2+influx via the mGluR1-mediated nonselective cation conductance. In contrast, when the dendriticVmis at rest, mGluR1s increase dendritic excitability by inactivating A-type K+channels, but this phenomenon is not restricted to the activated PF synapses. Thus,Vmis likely a crucial parameter in determining PF synaptic plasticity, and the occurrence of hyperpolarization episodes is expected to play an important role in motor learning.SIGNIFICANCE STATEMENTIn Purkinje neurons, parallel fiber synaptic plasticity, determined by coincident activation of the climbing fiber input, underlies cerebellar learning. We unravel the biophysical mechanisms allowing the CF input to produce a local Ca2+signal exclusively at the sites of activated parallel fibers. We show that when the membrane potential is hyperpolarized with respect to the resting membrane potential, type-1 metabotropic glutamate receptors locally enhance Ca2+influx mediated by T-type Ca2+channels, and that this signal is amplified by saturation of endogenous buffer also mediated by the same receptors. The combination of these two mechanisms is therefore capable of producing a Ca2+signal at the activated parallel fiber sites, suggesting a role of Purkinje neuron membrane potential in cerebellar learning.
The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector
Authors: Gamez Stephanie , Antoshechkin Igor , Mendez-Sanchez Stelia C , Akbari Omar S 
Published: January 2020

Abstract
Aedes albopictus mosquitoes are important vectors for a number of human pathogens including the Zika, dengue, and chikungunya viruses. Capable of displacing Aedes aegypti populations, this mosquito adapts to cooler environments which increases its geographical range and transmission potential. There are limited control strategies for Aedes albopictus mosquitoes which is likely attributed to the lack of comprehensive biological studies on this emerging vector. To fill this void, here using RNAseq we characterized Aedes albopictus mRNA expression profiles at 34 distinct time points throughout development providing the first high-resolution comprehensive view of the developmental transcriptome of this worldwide human disease vector. This enabled us to identify several patterns of shared gene expression among tissues as well as sex-specific expression patterns. To illuminate the similarities and differences with Aedes aegypti, a related human disease vector, we also performed a comparative analysis between the two developmental transcriptomes, identifying life stages where the two species exhibit similar and distinct gene expression patterns. These findings provide insights into the similarities and differences between Aedes albopictus and Aedes aegypti mosquito biology. In summary, the results generated from this study should form the basis for future investigations on the biology of Aedes albopictus and provide a gold mine resource for the development of transgene-based vector control strategies.
EL DISCURSO INDIRECTO LIBRE EN LA NARRATIVA DE MIGUEL ANGEL ASTURIAS
Authors: Rodríguez-Pasqués Mignon Domínguez de 
Published: January 2020

En este estudio se rastrea un recurso estilfstico no abordado hasta el presente en las novelas de M. A. Asturias. Se han seleccionado El señor presidente y El Alhajadito con el fin de estudiar las características que asume el DIL. En Asturias adquiere especial importancia cuando capta rumores inciertos o Ia opinión de un grupo, o cualquier expresión de una pluralidad, caso que se denomina "coral". El escritor guatemalteco, gana con el empleo del DIL ya que rompe la monotonía de la simple narración y quiebra con giro elegante la línea a veces demasiado rápida y objetiva del puro diálogo. Al final, se ofrece un calculo de frecuencias de DIL en ambas novelas. Parte de este artículo fue presentado como comunicación al IV Congreso de la Asociación Internacional de Hispanistas, Salamanca, 1971. MDRP
NATUREZA E HOMEM NA FORMAÇÃO CULTURAL DA AMÉRICA CHAMADA LATINA
Authors: Diégues Junior Manuel 
Published: January 2020

A descoberta do território americano e a sua subsequente colonização propiciaram o encontro de grupos distintos não apenas quanto às suas origens, mas igualmente quanto aos estágios culturais em que se encontravam. Do processo cultural surgido deste encontro participaram principalmente a cultura indígena aqui encontrada, com seus diferentes estágios, destacando-se grupos mais avançados como os incas, maias e astecas, e grupos menos desenvolvidos, e a cultura ibérica dos colonizadores, representada por portugueses e espanhóis, e a não menos importante cultura africana aqui chegada através do africano trazido como escravo. Este processo caracterizou-se principalmente por uma troca intensa e muitas vezes profunda de elementos culturais de um e outro grupo, resultando daí o que se conceituou como “criatividade cultural”, isto é, a criação de novos valores, fruto desta fusão sem que uma das culturas se impusesse de maneira absoluta sobre as demais. Dependendo apenas da predominância local de um ou outro grupo, seria possível pensar a América hoje Latina não como uma só cultura, mas como um agrupamento de diversos tipos, culturalmente regionalizados por fatores ecológicos humanos. A tipologia cultural que poderemos encontrar é basicamente a que resulta desse contato humano em sua relação com o meio; uma tipologia culturalmente ecológica
LAS DOS ESPAÑAS: TWO APPROACHES IN THE NOVEL OF THE 1840’S
Authors: T. Rodríguez Rodney 
Published: January 2020

El conflicto entre las dos Españas se convierte en tema novelístico precisamente cuando termina el absolutismo de Fernando VII. El escritor romántico, para enfocar aquella dicotomia que se hacía cada vez más patente, escogió entre una novela “filosófica” y una novela “tendenciosa”. En aquélla se distingue un intento de ahondar en la lucha entre la España moderna y tradicional por medio de n examen detenido de las causas de la contienda, siempre dentro de los límites estilísticos del romanticismo, pero sin sacar partido del tema. Ros de Olano analizó los conflictos políticos en El diablo las carga (1840). La avellaneda, en Dos mujeres (1842-43), estudió los valores morales de una época en transición. Em El Dios del siglo (1848), Salas y Quiroga investigó el transtorno ético que surge en una edad materialista. Sin embargo, otros escritores más comprometidos cultivaron uma novela tendenciosa em que dieron rienda suelta a sus pensamientos políticos y morales. Así ocurrió con Ayguals de Izco y los folletinistas liberales que usaron la novela para difundir ideas socialistas. La novela de Fernán Caballero, a pesar de representar una reacción artística y conservadora a las técnicas melodramáticas de los follentinistas y al radicalismo social, convino con ellos en el propósito pendenciero y propagandista del género. Este tipo de novela belicosa, que sólo sirvió para cristalizar aún más las facciones españolas, fue la que se arraigó al suelo hispánico. Por consiguiente, las primeras novelas realistas de Galdós, Pereda y Alarcón, que aparecieron a partir de la Revolución de Septiembre, siguieron esta corriente tendenciosa. Galdós luego se dará cuenta que la novela moderna, para reflejar la polaridad en que convivían los españoles, había de trocar el partidismo en el análisis profundo- cosa que ya habían advertido dos novelistas “filosóficos” de los años 40.
La amigable composición: el carácter de la decisión, su impugnación y ejecución. Una revisión crítica de la figura
Authors: Rodríguez Mejía Marcela 
Published: January 2020

El objetivo de este artículo de investigación es responder a la pregunta de investigación de si la amigable composición, tal y como hoy en día se encuentra regulado en el Estatuto Arbitral, es un mecanismo eficiente para resolver controversias.
Con ese objetivo en mente, se estudian y analizan tres cuestiones: cuál es el carácter de la decisión emitida por un amigable componedor; cómo se ejecuta esa decisión y con qué mecanismos de contradicción puede atacarse la misma.
Para resolver estos interrogantes, y utilizando el método hermenéutico -siempre de forma crítica-, se estudian e interpretan las tres normas de la Ley 1563 de 2012 que regulan la amigable composición, y las disposiciones del Código Civil que hacen lo propio con la transacción; primero de forma individual, y luego, debido al símil que la primera de estas normas hace a la transacción, de forma comparada.
Tidal Triggering of the Harmonic Noise in Ocean-Bottom Seismometers
Authors: Ramakrushana Reddy Telluri , Dewangan Pawan , Arya Lalit , Singha Pabitra , Kamesh Raju Kattoju Achuta 
Published: January 2020

AbstractWe observed a harmonic noise (HN) in DEutscher Geräte-Pool für Amphibische Seismologie ocean-bottom seismometers (OBSs) data recorded from the Andaman–Nicobar region. The HN is characterized by sharp spectral peaks with a fundamental frequency and several overtones occurring at integer multiples of the fundamental frequency. We used an automated algorithm to quantify the occurrence of HN for the entire four-month deployment period (1 January 2014 to 30 April 2014). The algorithm detected more than 23 days of HN for some OBS stations. The spectral analysis of the hourly count of HN shows distinct lunar and solar tidal periodicities at 4.14, 6.1, 6.22, 12, and 12.4 hr as well as 13.66 days. The observed periodicities provide evidence of tidal triggering of HN. The HN is generated by the strumming of head buoys due to seafloor currents initiated by oceanic tides in the Andaman–Nicobar region.
Using Daily Observations from Planet Labs Satellite Imagery to Separate the Surface Deformation between the 4 July Mw 6.4 Foreshock and 5 July Mw 7.1 Mainshock during the 2019 Ridgecrest Earthquake Sequence
Authors: Milliner Chris , Donnellan Andrea 
Published: January 2020

Abstract
On 4 July 2019, the Ridgecrest earthquake sequence began with a series of foreshocks including an Mw 6.4 event near Searles Valley, California. This was then followed 34 hr later by an Mw 7.1 mainshock located just 15 km to the north, with the earthquake sequence resulting in a complex array of intersecting faults. This earthquake sequence poses several interesting questions including, did the stress changes induced by the Mw 6.4 foreshock trigger the Mw 7.1 mainshock and what possible mechanism(s) could explain the occurrence of widespread secondary faulting surrounding both surface ruptures? However, most of the geodetic data (such as Interferometric Synthetic Aperture Radar, light detection and ranging, and optical satellite imagery) were acquired after both events had occurred making it difficult to discern which surface fractures happened when and their possible triggering mechanism. Here, we provide a dataset composed of high-resolution optical imagery, pixel-value difference maps, .kmz fracturing mapping, and horizontal deformation maps derived from subpixel image correlation, which can uniquely separate the surface fracturing and deformation between the foreshock and mainshock events that can help answer these questions. Separate imaging of the events is made possible by the daily acquisition of optical imagery by the Planet Labs cubesat constellation, which acquired data between the two earthquakes, in the morning of 4 and 5 July, at 11.13 a.m. and 05.12 p.m. PST, respectively, with the images acquired just 40 min after the foreshock and 56 min before the mainshock, respectively. Analysis from this optical imagery reveals the location of surface faulting that allows us to map their spatial extent and determine their timing. These data which we provide here can help guide and validate field survey observations to help understand which faults ruptured when, and constrain slip inversion models for more accurate estimates of stress changes induced by the foreshock imposed on the surrounding faults.
Variación fonética, a lingua da esfera pública e estándar oral: entre a lingüística e a política
Authors: Regueira Xosé Luís 
Published: January 2020

A preocupación polos modelos de lingua, especialmente os presentes na actividade pública, vén sendo obxecto de discusión nos últimos anos, baixo a etiqueta de “calidade da lingua” ou de “autenticidade”. Neste artigo arguméntase que o estudo da variación, especialmente desde a perspectiva da sociolingüística interaccional, resulta imprescindible para comprender o comportamento das persoas que están a usar a lingua no espazo público. A partir dese coñecemento a lingüística poderá realizar algunhas contribucións útiles para que as persoas que protagonizan eses espazos sociais poidan desenvolver as variedades que lles permitan alcanzar os seus obxectivos comunicativos, mais, cando menos no tocante á lingua oral, esas variedades non son susceptibles dunha planificación de arriba a abaixo como ocorre con certos aspectos do estándar escrito.
Challenges Experienced by HIV/AIDS-Positive Women in Marital Relationships; A qualitative study
Authors: Kalateh Sadati Ahmad , Taheri Vajihe , Hemmati Soroor 
Published: January 2020

Introduction: The prevalence of HIV/AIDS is alarmingly increasing. Considering the experiences of HIV/AIDS-positive patients, experiences of the women who took HIV/AIDS from their husbands –marital relationships- can be different. The purpose of this study was to describe the challenges of these women.
Methods: This qualitative study was conducted using focus group discussions with 10 women who took HIV/AIDS from their husbands. All interviews were recorded, transcribed verbatim, and analyzed by thematic analysis.
Results: Data analysis showed that participants experienced a kind of compulsive social isolation. They could not interact with anyone except their parents. They suffered from social stigma because the disease is associated with the illicit sex label. From data analysis, three main themes of fear, marital despondency, and stigma emerged.
Conclusion: The concerns and challenges of women who took HIV/AIDS from their marital relationships revealed that these women were exposed to the social strains because of having HIV / AIDS and stigma of illegitimate sexual relationships. In this regard, public awareness should be raised about this disadvantaged group of the community. To hit this target, individuals should be provided with the required information through schools as well as broadcasting and social media. Implementation of the counseling visits can create psychological and social support for these traumatized group and their families.
ADVERSITY QUOTIENT IN IMPROVING MILLENNIAL GENERATION SALESPEOPLE'S PERFORMANCE IN THE INDUSTRIAL REVOLUTION 4.0
Authors: Wiradendi Wolor Christian , Pratama Aditya , Aditya Shandy , Fadillah F Nadya , Purwana Dedi 
Published: January 2020

Purpose of the study: The paper aims to address the knowledge gap in understanding the relationship between AQ and the performance of millennial generation salespeople.
Methodology: This study uses a qualitative approach in a systematic review. This is used to synthesize(summarizing) qualitative descriptive research results.
Main Findings: The findings indicate that there is a positive relationship between adversity quotient on the performance of millennial generation salespeople.
Applications of this study: The study shows the importance of companies adopting AQ for millennial generation salespeople by training salespeople, especially in guiding them, to provide flexible space to make decisions, and explore their capabilities in the field of technology in achieving performance targets set by the company.
Novelty/Originality of this study: The results contribute to the literature by providing main factors of adversity quotient to achieve the performance of millennial generation salespeople on Industrial Revolution 4.0.