bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed culture microalgae removal for water quality improvement using chitosan
Authors: Singh Gulab , Patidar S.K. 
Published: June 2020

The presence of microalgae affects water quality and beneficial uses of surface freshwaters. Chitosan with proven potential for harvesting specific microalgae species from their culture medium to produce biofuels and bioproducts also appears promising for efficient removal of mixed microalgae species from surface freshwaters. The main focus of the present study was on removal of mixed microalgae species using chitosan as a coagulant to help improve water quality. Important operational parameters were optimized for economical microalgae removal. The microalgae cells, chlorophyll-a, total nitrogen, and total phosphorous removal efficiency were 82.06%, 89.90%, 69.32%, and 44.01%, respectively, at an optimum chitosan dose of 10 mg/L, pH 8, slow mixing time 7 min, slow mixing rate 30 rpm, and settling time of 15 min. The results show that chitosan coagulation efficiently removed mixed microalgae species from surface freshwater with significant improvement in water quality and recovery of algal biomass for other beneficial applications.
Fermionic decay of a massive scalar in the early universe
Authors: Lankinen Juho , Malmi Joonas , Vilja Iiro 
Published: June 2020

AbstractWe derive a curved space generalization of a scalar to fermion decay rate with a Yukawa coupling in expanding Friedmann–Robertson–Walker universes. This is done using the full theory of quantum fields in curved spacetime and the added-up transition probability method. It is found that in an expanding universe the usual Minkowskian decay rates are considerably modified for early times. For conformally coupled scalars the decay rate is modified by a positive additive term proportional to the inverse of mass and related to the expansion rate of the Universe. We compare and contrast our results with previous studies on scalar to scalar decay and find that in general the decay channel into fermions is the dominant channel of decay in the very early Universe.
Eu luminescence from BaTiO3/SiO2 multilayer xerogel structures
Authors: Gaponenko N. , Parafinyuk D. , Kholov P. , Raichenok T. , Prislopski S. 
Published: June 2020

Sol–gel technology was applied to fabricate Eu-doped BaTiO3/SiO2 multilayer structures by spinning on silicon and fused silica substrates. Eu photoluminescence (PL) was investigated depending on the annealing temperature of these structures. The samples demonstrate the room temperature luminescence corresponding to 5[Formula: see text]FJ ([Formula: see text], 2, 3, 4) transitions of trivalent europium with the most intensive band at 615 nm. For the structure on fused silica with Eu in the BaTiO3 cavity, increase of the annealing temperature from [Formula: see text]C to [Formula: see text]C results in modification of the luminescence indicatrix and lowering of the luminescence intensity in the direction along the surface normal. For BaTiO3/SiO2 multilayer structure generated on silicon, scanning electron microscopy (SEM) analyses reveal disordering after annealing at [Formula: see text]C. This heat treatment provides also an increase of the Eu luminescence intensity.
Crustal origin of the West Florida Terrane, and detrital zircon provenance and development of accommodation during initial rifting of the southeastern Gulf of Mexico and western Bahamas
Authors: Erlich R. N. , Pindell J. 
Published: June 2020

Abstract
Well and seismic data were combined with existing radiometric data and 1328 new laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U–Pb zircon ages from igneous, sedimentary and volcaniclastic rocks in three wells to determine the origin and evolution of key crustal terranes, and the timing of initial rifting and synrift deposition in the southeastern Gulf of Mexico and western Bahamas. These data reveal that several southeastern Gulf of Mexico crustal terranes, distinguished by their zircon age distributions and geochemistries, were amalgamated into a single terrane of mixed Pan-African and Amazonian crustal affinity (the newly named West Florida Terrane) during the formation of Pangaea. Sinistral offset along the Florida Transfer Zone (FTZ) during the Late Triassic–Middle Jurassic was likely to have been facilitated by crustal heterogeneity at the boundary between the West Florida and Suwannee terranes, a prime area for reactivation during the break-up of Pangaea. Initial extension, igneous activity and synrift deposition in the region began during the Middle Triassic in the western Bahamas and offshore North Florida, and rapidly expanded into the South Florida Basin by the Early Jurassic. Peak igneous activity and accommodation in the region was diachronous from north to south, beginning in the north during the Early Jurassic (Sinemurian–Pliensbachian) before ending in the south in the Early–Middle Jurassic (Sinemurian–Aalenian/early Bajocian). Detrital zircons in sedimentary and volcaniclastic rocks were primarily derived from local erosion of pre-existing crustal terranes. Long-distance transport was likely for pre-Neoproterozoic and post-Cambrian Paleozoic zircons. Middle Jurassic detrital zircons in volcaniclastic rocks of the western Bahamas may have been deposited during ash-fall events from hotspot activity in the southeastern Bahamas.
Cumulative Burden of Chronic Health Conditions in Adult Survivors of Osteosarcoma and Ewing Sarcoma: A Report from the St. Jude Lifetime Cohort Study
Authors: Bishop Michael W. , Ness Kirsten K. , Li Chenghong , Liu Wei , Srivastava Deo Kumar , Chemaitilly Wassim , Krull Kevin R. , Green Daniel M. , Pappo Alberto S. , Robison Leslie L. , Hudson Melissa M. , Mulrooney Daniel A. 
Published: June 2020

Abstract

Background:
Adult survivors of childhood osteosarcoma and Ewing sarcoma are at risk of developing therapy-related chronic health conditions. We characterized the cumulative burden of chronic conditions and health status of survivors of childhood bone sarcomas.

Methods:
Survivors (n = 207) treated between 1964 and 2002 underwent comprehensive clinical assessments (history/physical examination, laboratory analysis, and physical and neurocognitive testing) and were compared with community controls (n = 272). Health conditions were defined and graded according to a modified version of the NCI's Common Terminology Criteria for Adverse Events and the cumulative burden estimated.

Results:
Osteosarcoma and Ewing sarcoma survivors [median age 13.6 years at diagnosis (range 1.7–24.8); age at evaluation 36.6 years (20.7–66.4)] demonstrated an increased prevalence of cardiomyopathy (14.5%; P &lt; 0.005) compared with controls. Nearly 30% of osteosarcoma survivors had evidence of hypertension. By age 35 years, osteosarcoma and Ewing sarcoma survivors had, on average, 12.0 (95% confidence interval, 10.2–14.2) and 10.6 (8.9–12.6) grade 1–4 conditions and 4.0 (3.2–5.1) and 3.5 (2.7–4.5) grade 3–4 conditions, respectively, compared with controls [3.3 (2.9–3.7) grade 1–4 and 0.9 (0.7–1.0) grade 3–4]. Both survivor cohorts exhibited impaired 6-minute walk test, walking efficiency, mobility, strength, and endurance (P &lt; 0.0001). Accumulation of ≥4 grade 3–4 chronic conditions was associated with deficits in executive function [RR: osteosarcoma 1.6 (1.0–2.4), P = 0.049; Ewing sarcoma 2.0 (1.2–3.3), P = 0.01] and attention [RR: osteosarcoma 2.3 (1.2–4.2); P = 0.008].

Conclusions:
Survivors of osteosarcoma and Ewing sarcoma experience a high cumulative burden of chronic health conditions, with impairments of physical function and neurocognition.

Impact:
Early intervention strategies may ameliorate the risk of comorbidities in bone sarcoma survivors.
Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
Authors: Alicea Gretchen M. , Rebecca Vito W. , Goldman Aaron R. , Fane Mitchell E. , Douglass Stephen M. , Behera Reeti , Webster Marie R. , Kugel Curtis H. , Ecker Brett L. , Caino M. Cecilia , Kossenkov Andrew V. , Tang Hsin-Yao , Frederick Dennie T. , Flaherty Keith T. , Xu Xiaowei , Liu Qin , Gabrilovich Dmitry I. , Herlyn Meenhard , Blair Ian A. , Schug Zachary T. , Speicher David W. , Weeraratna Ashani T. 
Published: June 2020

Older patients with melanoma (&gt;50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (&lt;50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, especially ceramides. When melanoma cells are exposed to the aged fibroblast lipid secretome, or cocultured with aged fibroblasts, they increase the uptake of lipids via the fatty acid transporter FATP2, which is upregulated in melanoma cells in the aged microenvironment and known to play roles in lipid synthesis and accumulation. We show that blocking FATP2 in melanoma cells in an aged microenvironment inhibits their accumulation of lipids and disrupts their mitochondrial metabolism. Inhibiting FATP2 overcomes age-related resistance to BRAF/MEK inhibition in animal models, ablates tumor relapse, and significantly extends survival time in older animals.Significance:These data show that melanoma cells take up lipids from aged fibroblasts, via FATP2, and use them to resist targeted therapy. The response to targeted therapy is altered in aged individuals because of the influences of the aged microenvironment, and these data suggest FATP2 as a target to overcome resistance.See related commentary by Montal and White, p. 1255..This article is highlighted in the In This Issue feature, p. 1241
God Made Manifest: Josephus, Idolatry, and Divine Images in Flavian Rome
Authors: Forger Deborah L. 
Published: June 2020

Abstract
After the destruction of the Second Temple, Jews lived under Flavian lords who peppered Rome’s landscape with sculpted images of themselves, oftentimes suggesting that these images, and the emperors who stood behind them, functioned as gods in embodied form. This paper considers how these divine images impacted Jews, given that these same Jews lived under Roman authority yet also served the God of Israel alone. By analyzing Josephus’s Antiquities 11.331-334 in light of Israel’s strong anti-idolic tradition, I explore how the name of Israel’s God, inscribed on the high priest’s golden miter, may have functioned as visible counterpoint to the Flavians’ graven images. It is widely assumed that first-century Jews viewed God as invisible, incorporeal, and utterly removed from the material realm, but for Josephus at least God’s name offered a means by which Jews could gaze upon an aspect of their God in visible, perceptible, and material form.
Arctic Ocean and Hudson Bay Freshwater Exports: New Estimates from Seven Decades of Hydrographic Surveys on the Labrador Shelf
Authors: Florindo-López Cristian , Bacon Sheldon , Aksenov Yevgeny , Chafik Léon , Colbourne Eugene , Holliday N. Penny 
Published: June 2020

AbstractWhile reasonable knowledge of multidecadal Arctic freshwater storage variability exists, we have little knowledge of Arctic freshwater exports on similar time scales. A hydrographic time series from the Labrador Shelf, spanning seven decades at annual resolution, is here used to quantify Arctic Ocean freshwater export variability west of Greenland. Output from a high-resolution coupled ice–ocean model is used to establish the representativeness of those hydrographic sections. Clear annual to decadal variability emerges, with high freshwater transports during the 1950s and 1970s–80s, and low transports in the 1960s and from the mid-1990s to 2016, with typical amplitudes of 30 mSv (1 Sv = 106m3s−1). The variability in both the transports and cumulative volumes correlates well both with Arctic and North Atlantic freshwater storage changes on the same time scale. We refer to the “inshore branch” of the Labrador Current as the Labrador Coastal Current, because it is a dynamically and geographically distinct feature. It originates as the Hudson Bay outflow, and preserves variability from river runoff into the Hudson Bay catchment. We find a need for parallel, long-term freshwater transport measurements from Fram and Davis Straits to better understand Arctic freshwater export control mechanisms and partitioning of variability between routes west and east of Greenland, and a need for better knowledge and understanding of year-round (solid and liquid) freshwater fluxes on the Labrador shelf. Our results have implications for wider, coherent atmospheric control on freshwater fluxes and content across the Arctic Ocean and northern North Atlantic Ocean.
Interannual Subtropical Indian Ocean Variability due to Long Baroclinic Planetary Waves
Authors: Chapman Christopher C. , Sloyan Bernadette M. , O’Kane Terence J. , Chamberlain Matthew A. 
Published: June 2020

AbstractLow-frequency variability in the south Indian Ocean is studied by analyzing 200 years of output from a fully coupled climate model simulation. At time scales of 2–10 years, the variability is dominated by westward-propagating features that form on the eastern side of the basin. Using feature tracking and clustering, the spatiotemporal characteristics and preferred pathways of the propagating features are identified and studied in detail. By comparison of the phase speed and vertical structure of the propagating anomalies identified by the feature tracking with linear theory, we conclude that these features are likely mode 1 or 2 baroclinic planetary waves. The effects of this low-frequency variability on the climate system is investigated. By analysis of the mixed-layer temperature budget, it is shown that at particular geographic locations, the propagating features can substantially modify the near-surface ocean and induce significant fluxes of heat into the atmosphere. In turn, these heat fluxes can drive a coherent atmospheric response, although this response does not appear to feed back onto the ocean. Finally, we discuss the implications for the interannual climate predictability.
Resolution Dependence and Subfilter-Scale Motions in Idealized Squall-Line Simulations
Authors: Lai Kwan Tsaan , Waite Michael L. 
Published: June 2020

Abstract
In this paper, the sensitivity of idealized squall-line simulations to horizontal resolution, subgrid turbulence mixing scheme, and subfilter-scale motion is discussed. Inconsistent results from numerical simulations of convective systems have suggested that there are issues with the behavior of the subgrid turbulent mixing parameterizations with increasing resolution that still need to be understood. WRF is used to perform large-eddy simulation of an idealized squall line with horizontal grid spacings of 4 km, 2 km, 1 km, 500 m, and 250 m. While 4 km grid spacing is able to produce the general structure of the squall line, higher-resolution simulations produce more detailed structures. Individual convective cell size decreases, the maximum cloud top height increases, and the subgrid turbulence kinetic energy (TKE) ratio decreases as resolution increases. As found in past studies, 4 km grid spacing is not recommended as it contains an unreasonable amount of subgrid TKE, is not sufficient to resolve the large energy-containing eddies, and may even suppress propagation of the squall line. While horizontal resolution of 1 km can produce a squall line, there are several discrepancies between the 1 km case and higher resolutions, including trailing banded structures and inhibited three-dimensionalization. These issues at 1 km resolution are investigated by examining the subfilter energy transfer for the highest-resolution simulation filtered to a horizontal scale of 1 km. The subfilter energy transfer rate at a scale of 1 km is dominated by the streamwise and shear components. While dissipation dominates the transfer, a significant amount of backscatter also exists, which is not represented by most subgrid models.
Recruitment challenges in stroke rehabilitation randomized controlled trials: a qualitative exploration of trialists’ perspectives using Framework analysis
Authors: McGill Kris , McGarry Jodie , Sackley Catherine , Godwin Jon , Nicoll Avril , Brady Marian C 
Published: June 2020

Objective: To explore the underlying reasons for recruitment difficulties to stroke rehabilitation randomized controlled trials from the perspective of trialists. Design: A qualitative study using semi-structured interviews and Framework analysis. Participants: Twenty multidisciplinary stroke rehabilitation trialists across 13 countries with a range of clinical and research experience. Methods: Twenty semi-structured telephone interviews were carried out. Purposeful sampling ensured a range of opinions were gathered from across the international stroke rehabilitation research community. Using Framework analysis, the analytical framework was formed by three researchers and tested before being applied to the total dataset. Results: Three themes described the trialists’ perception of the underlying reasons for recruitment difficulties: (i) decision making, (ii) importance of recruiters and (iii) a broken system. Trialists described frequently disregarding evidence in favour of prior research experiences when planning randomized controlled trial recruitment. All felt that the relationship between the research and clinical teams was vital to ensure recruiters prioritized and found value in recruitment to the trial. Experienced trialists were frustrated by the lack of reporting of the reality of running trials, research governance demands and the feeling that they had to deliberately underestimate recruitment timeframes to secure funding. Conclusion: Stroke rehabilitation trialists described recruitment difficulties which may be related to their experiential based recruitment decision making, a lack of understanding of how best to incentivize and maintain relationships with recruiters and unrealistic bureaucratic expectations both in terms of gaining funding and research governance.
Clinical effectiveness of position management and manual rotation of the fetal position with a U-shaped birth stool for vaginal delivery of a fetus in a persistent occiput posterior position
Authors: Yang Lin , Yi Tongying , Zhou Min , Wang Cheng , Xu Xiaoying , Li Yufang , Sun Qingmei , Lin Xiaojuan , Li Jing , Meng Zhaoyan 
Published: June 2020

Objective To examine the effects of position management, manual rotation of the fetal position, and using a U-shaped birth stool in primiparous women with a fetus in a persistent occiput posterior position. Methods This was a prospective pilot study of women who delivered at Gansu Provincial Maternity and Child-care Hospital between January and June 2018. The women were divided into the position management ([PM] position management, manual rotation of fetal position, use of a U-shaped birth stool at different stages, and routine nursing) and control groups (position selected by women and routine nursing). Results There were 196 women in the PM group and 188 in the control group. There were no significant differences in maternal age, gestational weeks, newborn weight, and the neonatal asphyxia rate between the PM and control groups. The duration of labor was shorter in the PM group than in the control group. Pain and blood loss 2 hours after delivery and the episiotomy rate were significantly lower in the PM group than in the control group. Conclusion Applying position management, manual rotation of the fetal position, and using a U-shaped birth stool should be considered for women with a fetus in a persistent occiput posterior position.
Impact of enhanced recovery after surgery on postoperative neutrophil–lymphocyte ratio in patients with colorectal cancer
Authors: Liu Xiao , Wang Yuwei , Fu Zhongxue 
Published: June 2020

Objective To investigate the impact of enhanced recovery after surgery (ERAS) on the postoperative neutrophil–lymphocyte ratio (NLR) in patients with colorectal cancer. Methods A total of 200 patients with colorectal cancer who underwent surgery between January 2015 and November 2018 were enrolled in the study. They were divided into a traditional treatment group (n=100) and an ERAS group (n=100). The traditional treatment group underwent radical laparoscopic colorectal surgery, and the ERAS group underwent traditional treatment plus the ERAS protocol (preoperative improvement of glucose tolerance, unconventional indwelling stomach and urinary tubes, intraoperative body temperature management, fluid management, postoperative pain management, early oral feeding, and early activities). Clinical data were collected for all patients. NLR levels before and after surgery, and complications were compared between the two groups. Results Postoperative NLR was significantly lower in the ERAS compared with the traditional treatment group. The incidence of complications, including anastomotic leakage, pulmonary infection, urinary tract infection, and cardiopulmonary dysfunction were also significantly lower in the ERAS group. Conclusion Enhanced recovery after surgery can reduce the increase in postoperative NLR and reduce the occurrence of postoperative complications, which results will be of clinical value.
Intestinal flora alterations in patients with early chronic kidney disease: a case-control study among the Han population in southwestern China
Authors: Hu Qiongdan , Wu Kaiyan , Pan Wei , Zeng Yan , Hu Keqin , Chen Dingguo , Huang Xinchun , Zhang Qiong 
Published: June 2020

Objective In this case–control study, we retrospectively analyzed the intestinal flora compositions of patients with early-stage chronic kidney disease (CKD). Methods Forty-seven patients with early CKD who were treated at the Traditional Chinese Medicine Hospital between March and October 2018 were enrolled, and 150 healthy volunteers were enrolled in the healthy control group. Fresh stool samples were collected. The V3–V4 region of the bacterial 16S rRNA was amplified via PCR. Biterminal sequencing was performed using the Illumina MiSeq platform. The flora compositions were compared between the two groups. Results The Chao1 and Shannon indices showed significantly lower intestinal flora diversity and abundances in the CKD group than in the healthy controls. Beta diversity analysis revealed notable differences in the intestinal flora compositions between the groups. At the phylum level, Actinobacteria and Proteobacteria abundances were significantly higher in the CKD group. Thirty-one species differed significantly between both groups, among which, differences in Ruminococcus and Roseburia displayed the highest diagnostic values for distinguishing CKD patients from healthy controls. Conclusions Intestinal flora compositions are altered in early-stage CKD patients among the Han population in southwestern China.