bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple liver metastases with synchronous gastric and transverse colon cancer diagnosed by gastric perforation successfully treated by SOX plus bevacizumab and completely resected by surgery: a case report
Authors: Matsumoto Ryu , Mori Shinichiro , Kita Yoshiaki , Toda Hiroko , Sasaki Ken , Arigami Takaaki , Matsushita Daisuke , Kurahara Hiroshi , Maemura Kosei , Natsugoe Shoji 
Published: March 2020

Abstract
Background
Synchronous double cancer of the colon and stomach accompanied by liver metastasis is rare. It is often difficult to determine an appropriate treatment strategy for multiple liver metastases of synchronous gastric cancer and colorectal cancer. Multidisciplinary treatment is required based on the progression and location of each tumor and chemotherapy for complete resection.

Case presentation
A 57-year-old male who complained of acute abdominal pain and fever visited his local hospital. He underwent emergent surgery for peritonitis caused by a gastric perforation. The cytodiagnosis of ascites did not show any tumor cells. There was a liver metastasis in the lateral segment of the liver. We performed a primary closure of the defect and then applied an omentum flap. After surgery, the patient was diagnosed as having synchronous cStage IV transverse colon cancer with multiple liver metastases and cStage IIB gastric cancer. The [18F]-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed 18F-FDG uptake by the colon tumor and multiple liver metastases, but there was no uptake in the gastric tumor or lymph nodes. We retrospectively reevaluated the CT findings from a local hospital and detected a liver nodule in segment 2/3 (from 35 to 60 mm) and segment 6 (from 26 to 57 mm), and the tumors had dramatically grown in size in only 2 months. Because complete tumor resection would be difficult, S-1 and oxaliplatin (SOX) plus bevacizumab therapy was started to control tumor progression. After 20 courses of chemotherapy, the clinical diagnosis was ycStage IV transverse colon cancer and ycStage IIa gastric cancer. We planned a two-step procedure to completely resect the primary tumors and multiple liver metastases. We first performed a laparoscopic right-colon resection+D3 lymphadenectomy and open distal gastrectomy+D2 lymphadenectomy. The patient was discharged home on postoperative day 18. After 1 month, we performed open liver resection. The pathological findings showed that the transverse colon was ypT2 (MP) with grade 2 therapeutic effects and that there were no atypical cells in the gastric tumor and multiple liver nodules (pathological complete response).

Conclusion
The SOX plus bevacizumab regimen could be an option for controlling tumor progression in synchronous double cancer of the colon and stomach with liver metastasis and led to the complete resection of such tumors.
Long-term Stability after Reduction of Mandible Fracture by Keyhole Plate: Evaluation at the Time of Plate Removal
Authors: Cheon Kyeong-Jun , Cho Seoung-Won , Jang Won-Seok , Kim Ju-Won , Yang Byoung-Eun 
Published: March 2020

Abstract
Background
Various types of miniplates have been developed and used for the reduction of facial bone fractures. We introduced Yang’s Keyhole (YK) plate, and reported on its short-term stability. The purpose of this study was to evaluate the long-term stability of the YK plate, as a follow-up study, by examining the patients who had used the YK plate among the patients with the reduction of mandible fractures and who visited for plate removal.

Methods
We reviewed the medical records of 16 patients who underwent mandibular fracture fixation using a YK plate (group I) and 17 patients who underwent mandibular fracture fixation using a conventional plate (group II). Assessment was then made on malunion, occlusal stability, discomfort during the application, and clinical symptoms.

Results
From January 2015 to December 2017, a total of 36 patients underwent mandibular fracture surgery using a YK plate. A total of 16 patients received plate removal. Among them, 15 were male and 1 female. The average age was 26 years. The applied surgical sites were the 12 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of YK plate was an average of 335 days. During the same period, 45 people underwent surgery on the conventional plate. A total of 17 patients received plate removal. Among them, 15 were male and 2 females. The average age was 36 years. The applied surgical sites were the 8 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of the conventional plate was an average of 349 days. No malocclusion occurred at the time of removal, and occlusion was stable. No patient complained of joint disease or discomfort.

Conclusion
The YK plate system, in which the screw was first inserted and the plate was applied, for clinical convenience did not cause any particular problem and no significant difference from the conventional plate.
Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects
Authors: Cai Yi , Reddy Rajiv D. , Varshney Vishal , Chakravarthy Krishnan V. 
Published: March 2020

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significant impact in quality of life and mortality. To date there is ongoing research to determine the optimum therapy for PD. In this review we analyze the current data in the use of spinal cord stimulation (SCS) therapy for treatment for Parkinsonian symptoms. We specifically address waveform pattern, anatomic location and the role of spinal cord stimulation (SCS) as a salvage therapy after deep brain stimulation (DBS) therapy. We also outline current experimental evidence from preclinical research highlighting possible mechanisms of beneficial effects of SCS in this context. Though the use of SCS therapy is in its infancy for treatment of PD, the data points to an exciting area for ongoing research and exploration with positive outcomes from both cervical and thoracic tonic and BURSTDR spinal cord stimulation.
S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
Authors: Tumani H. , Petereit H. F. , Gerritzen A. , Gross C. C. , Huss A. , Isenmann S. , Jesse S. , Khalil M. , Lewczuk P. , Lewerenz J. , Leypoldt F. , Melzer N. , Meuth S. G. , Otto M. , Ruprecht K. , Sindern E. , Spreer A. , Stangel M. , Strik H. , Uhr M. , Vogelgsang J. , Wandinger K.-P. , Weber T. , Wick M. , Wildemann B. , Wiltfang J. , Woitalla D. , Zerr I. , Zimmermann T. 
Published: March 2020

Abstract
Introduction
Cerebrospinal fluid (CSF) analysis is important for detecting inflammation of the nervous system and the meninges, bleeding in the area of the subarachnoid space that may not be visualized by imaging, and the spread of malignant diseases to the CSF space. In the diagnosis and differential diagnosis of neurodegenerative diseases, the importance of CSF analysis is increasing. Measuring the opening pressure of CSF in idiopathic intracranial hypertension and at spinal tap in normal pressure hydrocephalus constitute diagnostic examination procedures with therapeutic benefits.
Recommendations (most important 3-5 recommendations on a glimpse):
The indications and contraindications must be checked before lumbar puncture (LP) is performed, and sampling CSF requires the consent of the patient.Puncture with an atraumatic needle is associated with a lower incidence of postpuncture discomfort. The frequency of postpuncture syndrome correlates inversely with age and body mass index, and it is more common in women and patients with a history of headache. The sharp needle is preferably used in older or obese patients, also in punctures expected to be difficult.In order to avoid repeating LP, a sufficient quantity of CSF (at least 10 ml) should be collected. The CSF sample and the serum sample taken at the same time should be sent to a specialized laboratory immediately so that the emergency and basic CSF analysis program can be carried out within 2 h.The indication for LP in anticoagulant therapy should always be decided on an individual basis. The risk of interrupting anticoagulant therapy must be weighed against the increased bleeding risk of LP with anticoagulant therapy.As a quality assurance measure in CSF analysis, it is recommended that all cytological, clinical-chemical, and microbiological findings are combined in an integrated summary report and evaluated by an expert in CSF analysis.

Conclusions
In view of the importance and developments in CSF analysis, the S1 guideline “Lumbar puncture and cerebrospinal fluid analysis” was recently prepared by the German Society for CSF analysis and clinical neurochemistry (DGLN) and published in German in accordance with the guidelines of the AWMF (https://www.awmf.org). /uploads/tx_szleitlinien/030-141l_S1_Lumbalpunktion_und_Liquordiagnostik_2019-08.pdf). The present article is an abridged translation of the above cited guideline. The guideline has been jointly edited by the DGLN and DGN.
Domesticated equine species and their derived hybrids differ in their fecal microbiota
Authors: Edwards J. E. , Schennink A. , Burden F. , Long S. , van Doorn D. A. , Pellikaan W. F. , Dijkstra J. , Saccenti E. , Smidt H. 
Published: March 2020

AbstractBackgroundCompared to horses and ponies, donkeys have increased degradation of dietary fiber. The longer total mean retention time of feed in the donkey gut has been proposed to be the basis of this, because of the increased time available for feed to be acted upon by enzymes and the gut microbiota. However, differences in terms of microbial concentrations and/or community composition in the hindgut may also underpin the increased degradation of fiber in donkeys. Therefore, a study was conducted to assess if differences existed between the fecal microbiota of pony, donkey and hybrids derived from them (i.e. pony × donkey) when fed the same forage diet.ResultsFecal community composition of prokaryotes and anaerobic fungi significantly differed between equine types. The relative abundance of two bacterial genera was significantly higher in donkey compared to both pony and pony x donkey:Lachnoclostridium10 and ‘probable genus 10’ from theLachnospiraceaefamily. The relative abundance ofPiromyceswas significantly lower in donkey compared to pony × donkey, with pony not significantly differing from either of the other equine types. In contrast, the uncultivated genus SK3 was only found in donkey (4 of the 8 animals). The number of anaerobic fungal OTUs was also significantly higher in donkey than in the other two equine types, with no significant differences found between pony and pony × donkey. Equine types did not significantly differ with respect to prokaryotic alpha diversity, fecal dry matter content or fecal concentrations of bacteria, archaea and anaerobic fungi.ConclusionsDonkey fecal microbiota differed from that of both pony and pony × donkey. These differences related to a higher relative abundance and diversity of taxa with known, or speculated, roles in plant material degradation. These findings are consistent with the previously reported increased fiber degradation in donkeys compared to ponies, and suggest that the hindgut microbiota plays a role. This offers novel opportunities for pony and pony × donkey to extract more energy from dietary fiber via microbial mediated strategies. This could potentially decrease the need for energy dense feeds which are a risk factor for gut-mediated disease.
Precise time scales and navigation systems: mutual benefits of timekeeping and positioning
Authors: Tavella Patrizia , Petit Gérard 
Published: March 2020

AbstractThe relationship and the mutual benefits of timekeeping and Global Navigation Satellite Systems (GNSS) are reviewed, showing how each field has been enriched and will continue to progress, based on the progress of the other field. The role of GNSSs in the calculation of Coordinated Universal Time (UTC), as well as the capacity of GNSSs to provide UTC time dissemination services are described, leading now to a time transfer accuracy of the order of 1–2 ns. In addition, the fundamental role of atomic clocks in the GNSS positioning is illustrated. The paper presents a review of the current use of GNSS in the international timekeeping system, as well as illustrating the role of GNSS in disseminating time, and use the time and frequency metrology as fundamentals in the navigation service.
Longitudinal Training-related Hematological Changes in Boys and Girls from Ages 12 to 15 yr
Authors: LANDGRAFF HEGE WILSON , HALLÉN JOSTEIN 
Published: March 2020

ABSTRACT

Purpose
Natural growth and maturation cause hemoglobin mass (Hbmass) and blood volume (BV) to increase during childhood and adolescence. Whether endurance training during the same period can cause further increases in these variables is not clear. Also, body composition develops differently in girls and boys during puberty, and the effect of these differences on hematological variables has not been previously studied.

Methods
Forty-two endurance athletes (End group; 24 boys) and 34 athletes from other sports (non-End group; 23 boys) were tested at ages 12, 13, and 15 yr for Hbmass, BV, plasma volume (PV), red cell volume (RCV), hematological variables, and anthropometrics.

Results
At age 12 yr, Hbmass and BV showed no difference between sexes and training groups in absolute values or relative to fat-free mass (FFM). Relative to FFM, Hbmass and BV averaged 11.7 (0.8) g·kg−1 and 95 (6.8) mL·kg−1. Increases in FFM from ages 12 to 15 yr primarily determined the increased Hbmass and BV for both sexes with no differences between training groups. At age 15 yr, Hbmass relative to FFM was higher in boys than girls, 13.1 (0.8) g·kg−1 and 12.1 (0.9) g·kg−1 (P < 0.001), whereas BV relative to FFM was not significantly different between sexes and training groups at any ages, averaged 100 (6.7) mL·kg−1 at age 15 yr. Relative to FFM, PV was higher in the End group at all ages, and RCV was, on average, lower and increased less compared with non-End group.

Conclusion
Our results indicate that increases in Hbmass during puberty are mainly associated with increased FFM and independent of sex or volume of endurance training.
However, the FFM-relative PV was higher and the FFM-relative RCV was lower in the End group compared with the non-End group.
Using a Neural Network to Minimize Pressure Spikes for Binary-coded Digital Flow Control Units
Authors: Elsaed Essam , Abdelaziz Mohamed , Mahmoud Nabil A. 
Published: March 2020

A unique method of improving energy efficiency in fluid power systems is called digital flow control. In this paper, binary coding control is utilized. Although this scheme is characterized by a small package size and low energy consumption, it is influenced by higher pressure peaks and larger transient uncertainty than are other coding schemes, e.g., Fibonacci coding and pulse number modulation, consequently resulting in poor tracking accuracy.
This issue can be solved by introducing a delay in the signal opening/ closing of the previous or subsequent valve, thus providing sufficient time for state alteration and valve processes. In a metering-in velocity control circuit, a feedforward neural network controller was used to create artificial delays according to the pressure difference over the digital flow control unit (DFCU) valves. The delayed signal samples fed to the controller were acquired through the genetic algorithm method, and the analysis was performed with MATLAB software.
High-speed all-optical thresholding via carrier lifetime tunability
Authors: Jha Aashu , Huang Chaoran , de Lima Thomas Ferreira , Prucnal Paul R. 
Published: March 2020

We theoretically study the effect of free-carrier lifetime on processing speed and strength of nonlinearity, pertaining to our all-optical thresholder. We find that optimal device performance necessitates tuning lifetime while optimizing for both speed and nonlinearity. We also experimentally demonstrate device processing speed improvement from 400 Mbps to 2.5 Gbps by incorporating PN-junction mediated free-carrier lifetime tuning mechanism. Our study on the significance of free-carrier lifetime is universally applicable to any optical signal processing system reliant on silicon photonic nonlinearities.
High-power DUV picosecond pulse laser with a gain-switched-LD-seeded MOPA and large CLBO crystal
Authors: Kohno Kenta , Orii Yosuke , Sawada Hisashi , Okuyama Daisuke , Shibuya Kimihiko , Shimizu Seiji , Yoshimura Masashi , Mori Yusuke , Nishimae Junichi , Okada George 
Published: March 2020

We report the generation of a 266 nm deep ultraviolet (DUV) picosecond pulse with an average output power of 14 W by the fourth-harmonic generation (FHG) from two consecutive frequency-doubling stages of a 1064 nm pulse based on a gain-switched-laser-diode (LD)-seeded hybrid fiber/solid-state master oscillator and power amplifier (MOPA) system. Through the gain-switched operation of a narrow-spectral-linewidth distributed-feedback laser diode and by using a Yb-doped fiber and a two-stage

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d

:

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O

4

solid-state amplifier, we achieved an average power of 46.5 W near the Fourier transform limit for a 13 ps pulse with a repetition rate of 200 kHz. The narrow linewidth pulse characteristics enabled highly efficient frequency conversion, and the efficiency of conversion from 532 to 266 nm was 54%, and from 1064 to 266 nm was 31%. The beam quality factor

M
2

of the generated DUV pulse was below 1.2. The highly efficient FHG process resulted in appeasing thermal stress caused by nonlinear absorption in the crystal, and more than 5000 h of continuous operation were achieved without any power down or beam profile degradation.
All-fiber polarization-maintaining mode-locked laser operated at 980  nm
Authors: Aleshkina Svetlana S. , Fedotov Andrei , Korobko Dmitrii , Stoliarov Dmitrii , Lipatov Denis S. , Velmiskin Vladimir V. , Temyanko Valery L. , Kotov Leonid V. , Gumenyuk Regina , Likhachev Mikhail E. 
Published: March 2020

For the first time, to the best of our knowledge, we present an all-fiber polarization-maintaining passively mode-locked picosecond laser operated at 980 nm. The laser cavity had a ring configuration with a semiconductor saturable absorber mirror as a mode-locking element. As an active medium, we used a specially designed cladding-pumped Yb-doped fiber with reduced cladding-to-core diameter ratio. The laser was self-starting and operated in the net cavity normal dispersion regime, where a spectral profile of the gain medium acted as a filter element. By intracavity spectral filtering, we achieved about 40 dB dominance of the signal wavelength at 980 nm over 1 µm emission in a highly stable picosecond pulsed regime. The corresponding simulation was performed to extend the knowledge about laser operation.
Megapixel time-gated SPAD image sensor for 2D and 3D imaging applications
Authors: Morimoto Kazuhiro , Ardelean Andrei , Wu Ming-Lo , Ulku Arin Can , Antolovic Ivan Michel , Bruschini Claudio , Charbon Edoardo 
Published: March 2020

We present a 1 Mpixel single-photon avalanche diode camera featuring 3.8 ns time gating and 24 kfps frame rate, fabricated in 180 nm CMOS image sensor technology. We designed two pixels with a pitch of 9.4 µm in 7 T and 5.75 T configurations respectively, achieving a maximum fill factor of 13.4%. The maximum photon detection probability is 27%, median dark count rate is 2.0 cps, variation in gating length is 120 ps, position skew is 410 ps, and rise/fall time is

<

550

p
s

, all FWHM at 3.3 V excess bias. The sensor was used to capture 2D/3D scenes over 2 m with resolution (least significant bit) of 5.4 mm and precision better than 7.8 mm (rms). We demonstrate extended dynamic range in dual exposure operation mode and show spatially overlapped multi-object detection in single-photon time-gated time-of-flight experiments.
Caixeiro viajante: aplicação da modelagem matemática na otimização de rotas em uma concessionária de energia elétrica
Authors: Ferreira Ivanilda Agustinho 
Published: March 2020

Este artigo apresenta um estudo de caso em uma concessionária de distribuição de energia elétrica brasileira com o objetivo de realizar uma aplicação sobre o Problema do Caixeiro Viajante (PCV). Visando otimizar as rotas das equipes de manutenção de subestações através da disponibilização de coordenadas do Google Maps das respectivas unidades consumidoras (UC) das subestações de um determinado estado. Essa otimização de rotas foi modelada utilizando o Problema do Caixeiro Viajante (PCV), juntamente com o Visual Basic for Applications (VBA) e o UFFLP integrado ao Microsoft Excel 2007. Com o intuito que as equipes de manutenção percorram o caminho de menor distância entre as possíveis subestações a serem visitadas, com a finalidade de executarem suas ordens de serviços. Desde que a equipe de manutenção, saísse primeiramente da sede da concessionária, percorresse as subestações estabelecidas e retornasse no final para a sede, sem existir a possibilidade de passar mais de uma vez na mesma subestação denominada de cliente, correspondendo assim, a melhor rota encontrada quando comparada com a sequência estabelecida inicialmente pela concessionária. Portanto, os gráficos e as figuras permitiram uma interpretação objetiva e notório sobre os dados e resultados dos indicadores de performance. Essa otimização contribui na redução do tempo gasto em deslocamentos, resultando em uma disponibilidade em mão de obra para executarem outras atividades. Influência também no aumento de indicadores de desempenho por equipe, além de diminuir os custos relacionados à manutenção dos veículos.
Petrophysical Investigation of the Khurmala Formation in Taq Taq Oil Field, Zagros Folded Belt
Authors: Rashid Fraidoon , Hussein Devan O. , Zangana Hawar A. 
Published: March 2020

The Tertiary rocks of Khurmala Formation in the Taq Taq oil field have been studied using wireline log analysis, drilling cutting descriptions with integration of mud logging report, and test results for understanding reservoir potentiality and fluid distribution. The formation comprised dolostone and dolomitic limestone with an intercalation of clay layers between the recognized beds. The formation has variable thickness throughout the field, 99.8 m from the northeastern limb and 109 m in the southeastern plunge. The calculated shale volume in the studied interval shows a high rate of the clay contents which in some points the gamma ray has 100% of shale. The corrected log-derived bulk porosity subdivided the Khurmala Formation into 5 porosity units from the top to the bottom including (Kh-1, Kh-2, Kh-3, Kh-4, and Kh-5). The first (Kh-1), third (Kh-3), and fifth (Kh-5) porosity units have the average porosity ≥0.10 (10%) that can be considered as good reservoir unit in terms of porosity, whereas the shale contents reduced the reservoir quality of these units. However, well hydrocarbon entrapment through interconnected fractures and fault in the other Tertiary reservoir was recorded in Taq Taq field , but the weak connectivity of the pores in the Khurmala Formation caused this rock interval remains as water bearing zone.