bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the winery's wastewater treatment system on the winery water footprint
Authors: Saraiva A. , Rodrigues G. , Mamede H. , Silvestre J. , Dias I. , Feliciano M. , Oliveira e Silva P. , Oliveira M. 
Published: December 2019

AbstractIn the Mediterranean region, water scarcity has already prompted concern in the wine sector due to the strong impact it has on vineyard productivity and wine quality. Water footprint is an indicator that takes account of all the water involved in the creation of a product and may help producers to identify hotspots, and reduce water consumption and the corresponding production costs. In recent years several studies have been reported on wine water footprint determination, but mostly focused on the viticulture phase or assuming no grey water footprint at the winery since it has a treatment system. In the framework of the WineWaterFootprint project a medium-size winery was monitored, with direct measurements, regarding determination of the blue and grey components of water footprint. The determined winery water footprint ranged from 9.6 to 12.7 L of water per wine bottle of 0.75 L, the wastewater produced being responsible for about 98%, which means that the grey component cannot be disregarded. The developed scenarios show that a potential reduction of 87% in winery water footprint can be obtained with almost no investment. The challenge of reducing the grey footprint is not in technology development, but rather in the proper maintenance and monitoring of treatment systems.
U.S. consumer price index in the second half of XX century: calculation strategy and ways of its changes
Authors: Kozlova M. A. 
Published: December 2019

The purpose of this research is a detection of U.S. consumer price index development and change ways emerged in the second half of XX century. Consumer price index is considered as a practically evaluable index number.Materials and methods. This research is based on the methodology documents of U.S. Bureau of Labor Statistics and its theoretical and practical papers published in Monthly Labor Review. The basic method is historical and descriptive techniques.Results. Data generalization for U.S. consumer price index across five revisions is realized in structure of the calculation method, adapted by ROSSTAT for the national consumer price index. Firstly the dynamic of number of cities, included in consumer price survey and changes of its sample is analyzed. Secondly the principles of point of purchase sampling is in focus. Thirdly the set of goods and services and dynamics of its structure are considered. Fourthly there is a generalization of pricing procedure principles that is frequency according to the type of cities and feature of goods and services. Fifthly the source and limits of data collecting for weights which needed for consumer price index calculation on the high level of aggregation. And sixthly there is description of mean price and price index calculation.Conclusion. The main ways of development and transformation in U.S. consumer price index are defined. It may be considered as alternative solutions in consumer price index of other countries. The main ways are the increase of city and goods sampling, extension of probability use, formation of good classification, equal temporal interval of weight renovation and creation of price index system.
Comparative analysis of clinical manifestations of primary hyperparathyroidisis by results of hospitalizations and screening for hypercalcia in the Arkhangelsk region
Authors: Baranova I. A. , Zykova T. A. , Sergeeva O. A. 
Published: December 2019

Objective: to compare the forms and clinical course of primary hypeparathyroidism in hospitalized patients over a ten-year period, with patients identified by a routine analysis of blood calcium in Arkhangelsk region.Material and methods: At the first stage, a retrospective analysis of 48 case histories of patients who received inpatient treatment for PHPT in two multidisciplinary hospitals in Arkhangelsk from 2005 to 2015 was carried out. At the second stage, a screening of blood calcium was performed in patients of large outpatient clinic in Arkhangelsk from March 1 to March 31, 2015, as a result of which 21 cases of the first established PHPT were detected. A comparative analysis of the clinical course was carried out in two groups of patients with PHPT compared with the control group.Results: patients with PHPT detected during screening showed a higher incidence of mild forms of the disease (38 %), a higher level of bone mineral density in all parts of the skeleton according to dual-energy X-ray absorptiometry, and a lower incidence of nephrolithiasis (24 % vs. 69 %) compared with hospitalized patients, among which the manifest forms of the disease prevailed (88 %), fibrocystic osteitis was detected in 44 % of cases, and coral nephrolithiasis - in 10% of cases.Conclusion: a routine study of blood calcium levels helps to identify primary hyperparathyroidism at earlier stages to prevent the development of severe complications and invalidisation of patients.
Age features of arterial human kidney vessels
Authors: Kaplunova O. A. 
Published: December 2019

Objective: to study the structural transformations of the architectonics of intra-organ renal arterial vessels in the age aspect.Materials and methods: 150 kidneys of people of diff erent age who died from the reasons which are not connected with diseases of cardiovascular and urinary systems are investigated. The studies were carried out using a set of methods: angiographic, macromicroscopic and morphometry.Results: with increasing age, a decrease in the number of vascular glomeruli in the kidney, the proportion of glomerular mass in the cortical substance of the kidney was found. In old age and in centenarians, a rare capillary network in the cortical substance of the kidney, tortuosity, narrowing and expansion of direct arterioles and capillaries in the cerebral substance was revealed. In old age and in centenarians, compared with adolescence, the relative content of arterial vessels in the cortical substance decreases by 6 times, in the juxtamedullary zone — by 4 and in the cortical substance — by 2 times.Conclusions: the large diameters of the juxtamedullary glomeruli and a large index of the relative content of arterial vessels in the juxtamedullary zone create prerequisites for possible juxtamedullary shunting with urgent adaptation in the norm. The decrease in these indicators in old age, the elderly and centenarians, obviously, explains the age-related decline in the adaptive capacity of the arterial bed of the kidneys. With increasing age, the range of adaptive capabilities of the renal vascular bed of aging people decreases compared to those of mature age.
Functional features of innate immunity in the development of postpericardiotomy syndrome in patients after coronary artery bypass grafting
Authors: Shlyk I. F. , Sizyakina L. P. , Sidorov R. V. , Shlyk S. V. 
Published: December 2019

Objective: to study the functional characteristics of innate immunity in the formation of postpericardial syndrome (PPS) in patients undergoing coronary artery bypass graft ing (CABG).Materials and methods: the study involved 60 people, 40 of them made up the main group of patients with coronary artery disease, which retrospectively aft er 1 month of observation was divided into 2 groups. Group I CABG and PPS, group II CABG without PPS. The control group consisted of 20 patients without IHD. Before surgery, aft er 5, 14 days and 1 month, the expression of toll-like receptors (TLRs) 2, 4, 9, the content of CD16+ and Granzyme B lymphocytes, the HCT test and serum α-defensin were evaluated in blood cells. Statistical analysis of the results of the study was carried out using the program Statistica 12.0 (StatSoft , USA). The difference in mean values between groups was evaluated by the Mann-Whitney test. Statistical signifi cance was considered signifi cant at p ≤ 0.05.Results: when comparing the initial indices of the main groups and the control group, an increase in the expression of TLRs 2, 4, 9 was revealed. An increase in the content of CD16+, as well as an increase in the cytotoxic activity of natural killers and an increase in the production of α-defensin.Conclusions: on the basis of the study, activation of the cellular link of innate immunity, an increase in the cytotoxic potential of natural killers and a signifi cantly high level of α-defensin both before and aft er CABG were revealed, which can play an important role in the development of PPS.
Reference intervals of the magnesium in the healthy individuals, residents of Astrakhan
Authors: Petrova O. V. , Nikulina D. M. , Martirosov M. U. 
Published: December 2019

Objective: to establish reference serum magnesium intervals in healthy individuals, residing in Astrakhan.Materials and methods: the investigated group was formed from 120 men and 120 women healthy residents of Astrakhan aged from 21 to 50 years (average age 37,6 ± 0,9). Th e study of calcium was carried out on an automatic biochemical analyzer “Cobas 311 c” (Roche Diagnostic, Germany) by photometric method.Results: the reference intervals for the magnesium in healthy men and women aged from 21 to 50 years, residing in Astrakhan is 0,72 – 0,99 mmol/L.Conclusion: the reference range of total magnesium, established by us, can be used in laboratories of Astrakhan, as it was developed taking into account domestic and foreign recommendations for selection donors for research and ensuring the quality of laboratory research at all stages.
Kesesuaian Kompetensi Soft Skill Lulusan Program Studi Bahasa/ Sastra Jepang Dengan Kebutuhan Dunia Kerja
Authors: Dwiwardani Wury , Wahidati Lufi 
Published: December 2019

One of the efforts to improve the quality of human resources is by building links and matches between educational institutions and industry. This link and match will support the growth of skilled human resources who can contribute optimally in various fields. In this regard, the question that often arises is whether universities, as institutions that play a role in educating young people, have produced graduates who have competencies that are in line with the needs of the industries. This research was conducted to identify hard skills and soft skill s typically required by the industries related to Japan and needed to be mastered by the graduates of Japanese Language/Literature Study Program who are working as Japanese speaking professional. Besides, this research aimed to analyze the weaknesses and problems faced by Japanese speaking professional when carrying out their work. The research data were collected from Japanese speaking professionals and the representative from Japanese companies located in Indonesia using questionnaires and interviews. Data obtained were then analyzed by referring to several references, including the results of the research conducted by M.M. Robles (2012) related to hard skills and soft skill s. The study finding about the strengths and weaknesses of Japanese Language Study Program graduates in Indonesia, can lead to improvement of the Japanese language learning, especially Japanese language learning in universities in Indonesia. So that the results of the study are expected to be taken into consideration in preparing and developing the curriculum of Japanese Language Studies Program in Universities, not only in the Vocational School of UGM, but also in other institutions in Indonesia.
ÜLKÜ MECMUASI (1933-1950) MÜZİK YAZILARI BİBLİYOGRAFİSİ
Authors: EROL Türker , AKGÜL Semih 
Published: December 2019

Ülkü Mecmuası, Erken Cumhuriyet Döneminde Halkevleri bünyesinde 1933-1950 yılları arasında çıkarılan ve içerisinde toplumsal ve kültürel anlamda pek çok makaleyi barındıran süreli bir yayın olarak bu çalışmaya konu olmuştur. Halkevlerinin merkez yayın organı niteliğinde çıkartılan Ülkü dergisi, dönemin hâkim anlayışına paralel olarak kurulan Halkevlerinin amaçlarını desteklemek ve hayata geçirilmeye çalışılan inkılap hareketlerinin fikri temellerini yaygınlaştırmak adına da önemlidir. Çalışmanın amacı; Ülkü Mecmuasındaki müzik yazılarını derlemek ve dönemin önde gelen stratejik yaygın eğitim kurumları olan halkevlerinin işlevini ve o dönem hayata geçirilmeye çalışılan müzik politikalarının temel yapısını kavramaktır. Bu doğrultuda Ülkü Mecmuasında yer alan yazılar incelenmiş olup, dergideki müzik yazıları konu ve dönemlerine göre tasniflenmiştir. Araştırmaya konu olarak ise toplam 272 sayı incelenmiş olup, söz konusu yazılar bibliyografik olarak derlenmiştir. Araştırmada veri toplama yöntemi olarak doküman incelemesi kullanılmış olup verilerin analiz aşamasında betimsel bir yaklaşım izlenmiştir. Bu çalışma, Ülkü Mecmuasını müzik yazıları bağlamında ele alan ilk çalışma olması sebebiyle önem taşımaktadır. Çalışmanın sonucunda; Halkevleri bünyesinde Ankara Halkevinin çıkardığı Ülkü Mecmuasının, dönemin ideolojisine paralel olarak, hayata geçirilmeye çalışılan müzik inkılabının halka benimsetilmesi amacıyla, tek partili dönemin önemli propaganda araçlarından birisi olduğu ve bu bağlamda yazı kaleme alan yazarların müzik politikalarının uygulanmasında rejimin sesi olduğu söylenebilir.
Role of ICH guidelines in registration of Pharmaceutical Products
Authors: Rahi Shivali , Rana Arpana 
Published: December 2019

The International Conference on Harmonization (ICH) of Technical Requirements is a unique project for Registration of Pharmaceutical products which are intended for human use. This brings together the regulatory authorities of Europe, Japan and United States and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration.
The purpose is to make recommendations on ways to achieve greater harmonization in the interpretation and application of technical guidelines and requirements for product registration in order to reduce or obviate the need to duplicate the testing carried out during the research and development of new medicines.
The objective of such harmonization is a more economical use of human, animal and material resources and the elimination of unnecessary delay in the global development and availability of new medicines whilst maintaining safeguards on quality, safety and efficacy and regulatory obligations to protect public health. It creates a venue that allows all key pharmaceutical regulatory authorities and industry stakeholders the opportunity to be more actively involved in pharmaceutical harmonization work. It aimed at the standardization of requirements and format along with the content of regulatory documentation and brings down the pressure on the price of medicines by enabling greater economies of scale and a labelled regulatory playing field. This paper is an effort to provide the detailed information about ICH Guidelines.
Customers' Perceptions on Pharmaceutical Regulatory Service Quality in Ethiopia
Authors: Beyene Kidanemariam G/Michael , Aga Deribe Assefa , Borta Heran Gerba , Tiruneh Mesafint Abeje 
Published: December 2019

Introduction: Service quality is a unique and abstract concept that is difficult to define and measure. It is an overall customer judgment that results from the comparison between service expectations and perceptions. There is no information on customers’ perception of pharmaceutical regulatory service quality in Ethiopia. Hence, this study aimed to assess customers’ perception of the Ethiopian Food, Medicine and Healthcare Administration and Control Authority’s pharmaceutical regulatory service quality.
Materials and methods: Cross-sectional study design was conducted from March 30 to May 30, 2017. Using simple random sampling technique, 131 respondents were included in the study. Structured questionnaire adapted from the SERVQUAL model was used to collect the data. Paired sample t-test and descriptive statistics were used for data analysis.
Results: The study found out that pharmaceutical regulatory service quality was low. Negative service quality gaps were observed in the five service quality dimensions and overall service quality. The widest service quality gap was in reliability and the narrowest gap was in the tangibility and assurance dimensions. The perception and expectation mean scores were 1.897±0.61 and 3.433±0.559 respectively.
Conclusions: Only 21.4% of the customers perceived that there was good service quality in the Authority while 78.6% claimed as poor. The study showed that there are service quality gaps in the pharmaceutical regulatory services. Hence, managers should look into the unmet needs and expectations or low perceptions of customers; and formulate effective strategies to ensure provision of better service quality.
Good Practices in Management of deficiencies in CTD dossier and comparative study for US, EU and Australia
Authors: Pooja Chaudhari  , Badjatya Jitendra Kumar 
Published: December 2019

This topic aims at reviewing the drug and drug product filing and obtaining USFDA EMEA and TGA approval and its effective role to improve the standards which are laid by them. The respective Regulatory Agency approves the new/generic drug products that govern respective market before introduction of particular product into the market. The Regulatory Agency approves the entire new drug product to be safe and effective before marketing. USFDA is the Regulatory Agency which is responsible for the regulation of food and drug product in USA. EMEA is the Regulatory Agency which is responsible for the regulation of food and drug product in Europe. TGA is the Regulatory Agency which is responsible for the regulation of therapeutic goods in Australia.
A dossier contains detail information about the drug substance and drug product and result of studies that are carried out in development process. For getting market authorization has to be submitted to the respective regulation bodies. Due to various regulations, ICH introduced CTD for such countries that come under it. CTD is critical for dossier submission. For regulatory submission that is to be accepted in all ICH countries.
CTD provides standardized structure. CTD makes filing easier globally. But there are differences in dossier submission requirements in these countries i.e. Module I is country specific and other regional guideline are also considered while compiling dossier application.
Kuznet’s Hypothesis and Ibn Khaldun’s Socio-Economic Dimensions
Authors: Indriati Isnan , Nugroho Muh Rudi 
Published: December 2019

This study aims to prove the relationship between the hypothesis of Kuznets and Ibn Khaldun's socio economic dimension and income inequality. The object employed in this study is five municipal districts in Yogyakarta with the highest value of inequality throughout Java. This research utilizes the data panel which is a combination of annual time series of data from 2004-2017 and cross section of data from the five municipal districts in Yogyakarta. In this study, dynamic data panel regression is performed with the Generalized Method Moment (GMM) Arellano Bond. The relationship of the economic dimension of Ibn Khaldun and income inequality has been used to calculate income inequality Theil Entropy index which is being the dependent variable, and other variables as proxy for each dimension in Ibn Khaldun's socio-economic dimension models. The result of this study indicates that the linkage between Kuznets's hypothesis and Ibn Khaldun's socio-economic dimensions is similar since the economic growth shows insignificant variable resulted in both models. Keywords: Kuznets hypothesis, Ibn Khaldun's socio-economic dimensions, Entropy Theil Index, Generalized Moment Method (GMM) Arellano Bond.
External Influences and Supports to Pesantren’s Socio-Economic Activism in the Changing Context
Authors: Isbah M. Falik 
Published: December 2019

This article aims to provide a context for discussions on pesantren’s socio-economic projects in contemporary Indonesia. It highlights current programs and engagements of agencies with pesantren in facilitating and supporting them to carry out socio-economic projects. In doing so, it will discuss the current programs of Nahdlatul Ulama (NU), particularly its organisational arms RMI (Rabitah Ma'ahid al Islamiyah, Association of Islamic Pesantren) and Lakpesdam (Lembaga Pengembangan Sumberdaya Manusia, Institute for Human Resource Development) which support the socio-economic role of pesantren. Then, the article will provide an overview of NGO’s programs in partnership with pesantren. The following section discusses examples of technical and financial support to pesantren from organisations promoting Islamic microfinance. The last section assesses government’s economic projects involving pesantren as to what extent they have affected pesantren’s community engagement. I argue that those external factors have not significantly strengthened pesantren’s capacity to carry out their socio-economic projects. This argument is built on my attempt to assess the extent to which these organisations have contributed to the strengthening of the capacity of pesantren to manage socio-economic projects for their communities. Keywords: pesantren, socio-economic activism, external supports, NGOs, Nahdlatul Ulama
Lombok as An Indonesian Halal Travel Destination
Authors: Haris Helmi , Nashirudin Muh. 
Published: December 2019

This study examines Lombok, as an Indonesian halal travel destination, through Global Muslim Travel Index (GMTI) analysis. GMTI requires four main indicators of assessing a halal destination, namely access, communication, environment and service. This study finds that Lombok is a promising island to be a halal travel destination, even it will be the best halal tourism place in Indonesia. However, the development of this destination should put in priority. The local government should take part in translating the halal destination concept to the grassroot level of tourism industry, whether in terms of tradition, culture, environment and other main indicators. Keywords: Lombok, halal tourism, travel destination, GMTI
A Literature Review on Green Supply Chain Management Adoption Drivers
Authors: Masudin Ilyas 
Published: December 2019

This article provides a systematic literature review of the driving factors influencing the application of green supply chain management (GSCM). The GSCM adoption issues have been widely given attention by researchers and practitioners since the adoption of GSCM would impact significantly on an organization's environmental, social, and financial performance. Most GSCM adoption has been discussed in the perspective of logistics management activities such as procurement, manufacturing, transportation, and reverse logistics. Nowadays, the discussion of GSCM adoption in terms of the driving factors affecting a successful GSCM application has led to complexity. In this article, a further review and discussion are conducted in terms of the driving factors dealing with GSCM adoption, including three major points, such as the driving forces of green procurement, green manufacturing, and green distribution and reverse logistics adoption. The driving factors are reviewed to highlight the recent factors affecting GSCM adoption. In this article, 94 papers from the past study are presented, associating each point of the discussion.