bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis on randomized controlled trials of colorectal cancer over the last decade
Authors: Hu Jun-hong , Wang Chen-Yu , Zhou Shi-Can , Li Xing-Wang , Li Bing-Hui , Zhang Jun-jie , Ge Zheng , Zhang Quan 
Published: February 2020

Abstract
Background The aim of this bibliometric analysis was to evaluate the clinical trials of randomized controlled trials (RCTs) of colorectal cancer all the world over the past decade. Methods The PubMed and Web of Science database were searched to obtain a randomized controlled trial of colorectal cancer from January 1, 2008 to January 1, 2018.The included literatures were analyzed with the bibliometric analysis. Results In the past 10 years, Randomized controlled trials of colorectal cancer have shown an upward trend; Most of the top ten research institutions in the literature are from the USA, the UK and other regions which has the high incidence of colorectal cancer; Most of the related research journals are also sponsored by European and American countries; the frequently cited top 15 literatures are mostly international multi-center clinical research, and there are fewer participants in Chinese research institutions. By keyword co-occurrence, colorectal cancer research mostly involves screening, disease-free survival, drug treatment, surgical methods, clinical trials, quality of life and prognosis; The results of the co-authorship network analysis show that Chinese researchers are less involved in international cooperation. Conclusions High-quality randomized controlled trials are increasingly favored by top international journals. However, there is still a large gap in clinical research between China and abroad. Researchers should gradually implement the standardization and accuracy of clinical trials, strengthen international multi-center cooperation and emphasize quality control.
Postoperative controls of ventilation tubes in children - by general practitioner or otolaryngologist? Study protocol for a multicenter, randomized, controlled trial (The ConVenTu study)
Authors: Austad Bjarne , Nilsen Ann Helen , Helvik Anne-Sofie , Albrektsen Grethe , Nordgård Ståle , Thorstensen Wenche Moe 
Published: February 2020

Abstract
Background Insertion of ventilation tubes (VTs) in the tympanic membrane is one of the most common ambulatory surgeries performed on children. Postoperative care may continue for two or more years and is today mostly done by otolaryngologists. Controls by general practitioners (GPs) may represent a sufficient level of health care regarding clinical outcome, but there exist no evidence-based guidelines concerning the level of expertise for this task. Aim To evaluate whether postoperative care after surgery with VTs performed by GPs represent a sufficient alternative to otolaryngologists. Methods/design Randomized controlled trial including patients from seven hospitals in all four Regional Health Authorities in Norway. A total of 400 children aged 3-10 years will be randomized to postoperative care by either otolaryngologist or their regular GP after surgery with VTs in the tympanic membrane. Two years after surgery we will compare hearing thresholds, middle ear function, complication rate, health related quality of life as well as the guardians’ evaluations of the postoperative care. Discussion Results from the ConVenTu study are expected to contribute with knowledge necessary to develop evidence-based guidelines regarding the level of expertise for safe postoperative care for children after surgery with VTs.
Anti- Ehrlichia properties of the dichloromethane extract of Ageratum conyzoides
Authors: Rosário Carla Janaina Rebouças Marques do , Rocha Claudia Quintino da , Aguiar Daniel Moura de , Lima Cristian Alex Aquino , Silveira Daniella Patrícia Brandão , Leite José Antônio Costa , Coutinho Denise Fernandes , Melo Ferdinan Almeida 
Published: February 2020

Abstract
Ehrlichia canis is an intracellular bacterium that infects hematopoietic cells. It is the causative agent of canine monocytic ehrlichiosis (CME). The disease may be acute, subclinical, or chronic, and is treated with tetracyclines including doxycycline. However, this class of tetracyclines may cause several side effects due to prolonged treatment. Bacterial resistance to antimicrobials has been extensively reported. The present study aimed to assess the anti- Ehrlichia activity of the dichloromethane extract (DCM) of Ageratum conyzoides L. on Ehrlichia- infected DH82 cells. For this purpose, the DCM extract of A. conyzoides collected in the municipality of São Luís, State of Maranhão (MA), northeast Brazil, was obtained from the aerial parts of the plant by exhaustive percolation in H 2 O- CH 2 Cl 2 (2:8) and subsequent extraction of the chemical compound. The chemical composition of these samples was investigated. The anti- Ehrlichia properties of A. conyzoides were confirmed in Ehrlichia- infected DH82 cells at a concentration of 200 μg.mL -1 of its DCM extract. The results of the treatments were evaluated at 18h and 36h after the insertion of the treatments evaluated with A. conyzoides.Based on the results of the chemical analysis of the samples, we may attribute these antirickettsial properties to the compounds from the lignan family that are found in this medicinal plant .
Clinical and cytopathologic characteristics of lymphoid neoplasms involved with serous effusions: a single center experience
Authors: gong xubo , Shao Sijia , Fu Yanbiao , Wang Lin , Hu Bailai , Xiao Xibin , Yan Lijuan , Zhao Xiaoying 
Published: February 2020

Abstract
Background: Lymphoid neoplasms in serous effusions (SEs) were uncommon. Currently, most reports of lymphoid neoplasms in SEs were from Western countries, but few reports were from China, and the details were still unclear. Methods: Between January 2004 and December 2019, lymphoid neoplasms diagnosed by cytological methods from specimens of pleural effusions (PEs), ascites, and pericardial effusions in our hospital were reviewed.Results: 59 patients of lymphoid neoplasms were diagnosed by SEs, the top three causes were diffuse large B-cell lymphoma (DLBCL) (n=21, 35.6%), myeloma (n=13, 22.0%), and T-lymphoblastic lymphoma (n=5, 8.5%). In PEs involved with DLBCL, the cytomorphology of DLBCL cells was variable, most PEs were present during tumor course (92.9%), bilateral PEs were the predominance (57.2%), and the median survival time was only 1.23 months after effusion. In PEs involved with myeloma, nearly all cases had a high ratio of immature to mature plasma cells (>1.0), IgA (36.4%) and light chain λ (36.4%) were the most frequently found. Bilateral PEs were easily found (90.9%), and the median survival time was only 1.4 months after effusion. Solitary plasmacytomas with myeloma infiltration in PEs seemed to have a better prognosis than that of plasma cell myeloma.Conclusion: Some differences are found between our patients and those from Western countries, and more studies involving different ethnic populations could help to elucidate the features of lymphoid neoplasms in SEs.
Neutrophil-to-lymphocyte ratio is a predictor of renal dysfunction in diabetic patients
Authors: Akase Taichi , Kawamoto Ryuichi , Ninomiya Daisuke , Kikuchi Asuka , Kumagi Teru 
Published: February 2020

Abstract
Background: Neutrophil-to-lymphocyte ratio (NLR) has been widely evaluated as a biomarker in various medical and surgical prognoses, but its usefulness in diabetic kidney disease is not yet known. Methods: This prospective observational study included outpatients, comprised of 190 men aged 73 ± 11 (mean ± standard deviation) years and 175 women aged 77 ± 10 years at baseline, from a rural hospital. We examined the relationship between baseline NLR calculated by analyzing the differential leukocyte counts in the complete blood count and the 1.5-year estimated glomerular filtration rate (eGFR) decline rate (i.e. 1.5-year eGFR − baseline eGFR) *100/baseline eGFR. Rapid eGFR decline rate was defined as a value <－15%. Results: Multiple linear regression analysis using rapid eGFR decline rates as objective variables, adjusted for confounding factors as explanatory variables, showed that tertiles of NLR (β=0.120, p=0.018) as well as hemoglobinA1c, presence of antidiabetic medication, and urinary albumin excretion were significantly and independently associated with a rapid eGFR decline rate. The multivariate-adjusted odds ratios (95% confidence interval) of the 2nd and 3rd tertiles of baseline NLR for rapid eGFR decline rate were 3.94 (1.34-11.6) and 3.93 (1.26-12.3), respectively. Multivariate-adjusted mean eGFR (95% confidence interval) values after 1.5 years categorized by tertile of baseline NLR were: 1st, 64.2 (62.1-66.3); 2nd, 60.5 (58.5-62.6); and 3rd, 59.1 (57.0-61.2). Conclusions: These results suggest that baseline NLR might be a useful biomarker for renal function decline in diabetic outpatients.
Cost-effectiveness analysis of osimertinib for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small cell lung cancer in Singapore
Authors: Aziz Mohamed Ismail Abdul , Foo Wayne Yong Xiang , Toh Chee Keong , Lim Wan-Teck , Ng Kwong 
Published: February 2020

Abstract
Background: Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases and is usually associated with a poor prognosis. However, targeted therapy with 1st and 2nd generation tyrosine kinase inhibitors (TKIs) has so far improved progression-free survival of epidermal growth factor receptor (EGFR) mutant NSCLC patients. Osimertinib, a third generation EGFR TKI has recently shown improved overall survival in previously untreated EGFR mutant NSCLC patients. We assessed the cost-effectiveness of osimertinib versus standard EGFR TKIs (gefitinib or erlotinib) as first-line treatment for advanced or metastatic EGFR mutant NSCLC patients in Singapore. Methods: A partitioned survival model with three health states (progression-free, progressive disease, and death) was developed from the Singapore healthcare payer perspective. Survival curves from the FLAURA trial were extrapolated beyond trial period over a 10-year time horizon to estimate the underlying progression-free survival and overall survival parametric distributions. Health state utilities were derived from the literature and direct costs were sourced from public healthcare institutions in Singapore. Deterministic and probabilistic sensitivity analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Results: Compared with 1st or 2nd generation TKI, osimertinib had a base-case incremental cost-effectiveness ratio (ICER) of SG$418,839 per quality-adjusted life year gained. One-way sensitivity analysis showed the ICER was most sensitive to time horizon and variations in progression-free utility values. Scenario analyses showed that a 50% reduction in the cost of osimertinib was still associated with a high ICER that was unlikely to be deemed cost effective. Conclusions: Osimertinib is not cost effective as a first-line treatment compared to standard EGFR TKIs in advanced EGFR mutant NSCLC patients in Singapore. The findings from our evaluation, alongside other considerations including the lack of survival benefit in the Asian subgroup of the FLAURA trial, will be useful to inform policy makers on funding decisions for NSCLC treatments in Singapore.
Etoricoxib decreases mouse subchondral bone mass and biomechanical properties in early osteoarthritis
Authors: Liu Bo , Ji Chenchen , Shao Yijie , Liang Ting , He Jiaheng , Jiang Huaye , Chen Guangdong , Luo Zong-Ping 
Published: February 2020

Abstract
Background Etoricoxib, a selective Cyclooxygenase-2 (COX-2) inhibitor, is commonly used in osteoarthritis (OA) for pain relief. The purpose of our study was to investigate the effects of Etoricoxib on mouse subchondral bone in early OA. Methods OA was induced via destabilization of the medial meniscus (DMM) in C57BL/6J mice. After surgery, the mice were randomly and equally divided into five groups: a sham-operated control group (Sham group), an osteoarthritis (OA) group (DMM group), an OA treated with Etoricoxib 5mg/kg (DMM+E5) group, an OA treated with Etoricoxib 10mg/kg (DMM+E10) group, and an OA treated with Etoricoxib 20mg/kg (DMM+E20) group. Mice in the Sham group and DMM group were injected with a similar dose of vehicle (40% ethyl alcohol–saline solution). Four weeks after treatment, mice were euthanized. Micro computed tomography (Mirco-CT) analysis, Safranin O-Fast Green staining, hematoxylin and eosin (HE) staining were performed to evaluate morphological and structural changes. In addition, atomic force microscopy (AFM) analysis was performed to evaluate changes in the elastic modulus. Furthermore, changes in microstructure were detected by scanning electron microscopy (SEM). Results Etoricoxib inhibited osteophyte formation in the subchondral bone. However, it also reduced the bone volume fraction (BV/TV), lowered trabecular thickness (Tb.Th), and more microfractures and pores were observed in the subchondral bone. Moreover, Etoricoxib reduced the elastic modulus of subchondral bone. Furthermore, exposure to Etoricoxib further increased the empty/total osteocyte ratio of the subchondral bone. In cartilage and synovium, Etoricoxib did not significantly change the Osteoarthritis Research Society International (OARSI) score, the modified Mankin score, and the synovialitis-score versus the DMM group. Conclusion Although Etoricoxib can relieve the pain induced by OA, it can also change microstructures and biomechanical properties of the subchondral bone at the early stage of OA, cause osteoporotic changes in subchondral bone structure, increase the risk of fragile fracture of subchondral bone.
Endobronchial valve in complex treatment of patients with drug resistant fibrous cavernous pulmonary tuberculosis
Authors: Askalonova O. Yu. , Tseymakh E. A. , Levin A. V. , Zimonin P. E. 
Published: February 2020

The objective of the study: to assess the efficacy of complex treatment with endobronchial valve implantation in the patients suffering from drug resistant fibrous cavernous pulmonary tuberculosis.Subjects and methods. Treatment outcomes in 97 patients with limited fibrous cavernous pulmonary tuberculosis were analyzed. Main Group included 42 patients who had bronchial valve block implanted. Comparison Group included 55 patients. Artificial pneumoperitoneum was used in both groups.Results. In Main Group, sputum conversion was achieved in 12 months in 40 (95.2%) patients, and in 32 patients (58.2%) in Comparison Group (p < 0.01). In 12 months after treatment start, positive X-ray changes were observed in 42 (100%) patients of Main Group and 40 (72.7%) patients of Comparison Group. Healing of cavities in 12 months was observed only in the patients from Main Group (26 (61.9%) patients). Upon completion of the study, surgery was still indicated to 4 (9.5%) of patients from Main Group and to 35 (63.6%) patients from Comparison Group.
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019
Authors: Ivanova D. A. , Borisov S. E. , Rodina O. V. , Filippov A. V. , Ivanushkina T. N. , Litvinova N. V. 
Published: February 2020

The objective: safety assessment of chemotherapy regimens compiled in accordance with the recommendations of World Health Organization (WHO), 2019, in patients with multiple drug resistant tuberculosis (MDR) in clinical practice settings.Subjects: Frequency, patterns, severity and risk factors of adverse events (AE) of chemotherapy regimens compiled in accordance with the WHO recommendations as of 2019 were analyzed in 122 patients with MDR and XDR respiratory tuberculosis within programmatic use of new anti-tuberculosis drugs.Results. The frequency of AE made 64.8% (95% CI 55.9-72.7%), gastrointestinal, cardiovascular and allergic events prevailed, the comorbidity was the risk factor of AE development (OR 6.44; 95% CI 1.91-21.76). AEs of with severity degrees 3-4 were observed in 24.6% (95% CI 17.8-33.0%), neurotoxic, ototoxic and hepatotoxic reactions prevailed; risk factors included female sex (OR 3.15, 95% CI 1.32-7.53) and complications of chemotherapy in the past (OR 3.50%, 95% CI 1.49-8.70). At least one anti-tuberculosis drug was canceled due to AE in 26.2% (95% CI 19.2-34.7%), and any of Group A drugs was canceled during the first 6 months of chemotherapy in 13.9% (95% CI 8.8-21.3%) of patients.
Experimental investigation of the effect of nickel on the electrical resistivity of Fe-Ni and Fe-Ni-S alloys under pressure
Authors: Pommier Anne 
Published: February 2020

AbstractElectrical resistivity experiments were conducted on three alloys in the iron-rich side of the Fe-Ni(-S) system (Fe-5 wt% Ni, Fe-10 wt% Ni, Fe-10 wt% Ni-5 wt% S) at 4.5 and 8 GPa and up to 1900 K using the multi-anvil apparatus and the 4-electrode technique. For all samples, increasing temperature increases resistivity. At a specified temperature, Fe-Ni(-S) alloys are more resistive than Fe by a factor of about 3. Fe-Ni alloys containing 5 and 10 wt% Ni present comparable electrical resistivity values. The resistivity of Fe-Ni(-S) alloys is comparable to the one of Fe = 5 wt% S at 4.5 GPa and is about three times higher than the resistivity of Fe = 5 wt% S at 8 GPa, due to a different pressure dependence of electrical resistivity between Fe-Ni and Fe-S alloys. Based on these electrical results and experimentally determined thermal conductivity values from the literature, lower and upper bounds of thermal conductivity were calculated. For all Ni-bearing alloys, thermal conductivity estimates range between ~12 and 20 W/(m⋅K) over the considered pressure and temperature ranges. Adiabatic heat fluxes were computed for both Ganymede's core and the Lunar core, and heat flux values suggest a significant dependence to both core composition and the adiabatic temperature. Comparison with previous thermochemical models of the cores of Ganymede and the Moon suggests that some studies may have overestimated the thermal conductivity and hence, the heat flux along the adiabat in these planetary cores.
New IR spectroscopic data for determination of water abundances in hydrous pantelleritic glasses
Authors: Stabile Paola , Appiah Ernestina , Bello Marco , Giuli Gabriele , Paris Eleonora , Carroll Michael R. 
Published: February 2020

Abstract
To aid current work on the genesis of pantelleritic magmas, and the desire to use IR spectroscopy to measure water contents in natural (e.g., melt inclusions) and experimental glasses of pantelleritic composition, we have determined molar absorptivities for near-infrared (NIR) absorption bands related to molecular water (5200 cm–1) and OH groups (4500 cm–1) in synthetic hydrous pantelleritic glasses, with compositions similar to natural pantellerites from the Eburru complex of the Kenya Rift Valley. The experiments were conducted at P = 30 to 150 MPa and T = 850–900 °C using a synthetic pantelleritic starting composition with (wt%) SiO2 = 76.60, Al2O3 = 8.48, FeO* = 5.48, K2O = 3.68, Na2O = 4.72, and with molar ratio (Na+K)/Al = 1.38. The experiments were H2O undersaturated (~1.1 to 6.5 wt% H2O), and the run products were analyzed by Karl-Fischer Titration (KFT) for total dissolved H2O abundance. Different combinations of baseline types (GG or TT) and intensity measurements (peak height and peak area) were applied to measure both hydroxyl group (OH) and molecular water (H2O) in the experimental samples. For instance, evaluating the peak heights and using the TT baseline ε4500 results to be equal to 0.98(4) (L mol-1cm–1) and ε5200 to 1.92(2) (L mol-1 cm–1); these values differ by ~20 to 50% from published values for metaluminous rhyolitic compositions.
Derap Langkah Pemuda sebagai Fasilitator Majelis Pemberdayaan Masyarakat Pimpinan Pusat Muhammadiyah di Tempat Pembuangan Sampah Terpadu (TPST) Piyungan
Authors: Farid Muhammad Rifa’at Adiakarti 
Published: February 2020

<p>This dedication provides an overview of empowerment efforts for scavengers in TPST Piyungan. The focus of assistance is aimed at preventing and managing disease that threatens scavengers. The purpose of this study is (1) To find out the problems faced by the Community Empowerment Council (MPM) in carrying out community empowerment programs in TPST Piyungan. (2) Knowing the impact of community empowerment programs conducted by MPM in TPST Piyungan (3) Knowing the role and participation of youth in community empowerment programs carried out by MPM at TPST Piyungan. This research uses descriptive qualitative method. The results showed (1) Problems faced by MPM came from the surrounding community who did not know the empowerment program in detail (2) Impacts that occurred in the community were united in a community that had been scattered in several collectors groups and better understood their potential (3) Youth who are members of the community empowerment facilitator play an active role in conducting empowerment programs.</p><p> </p><p>Pengabdian ini memberikan gambaran upaya pendampingan bagi pemulung di TPST Piyungan. Fokus pendampingan ditujukan pada pencegahan dan penanggulangan pemyakit yang mengancam pemulung. Tujuan penelitian ini adalah (1)<strong> </strong>Mengetahui masalah yang dihadapi Majelis Pemberdayaan Masyarakat (MPM)<strong> </strong>dalam menjalankan program pemberdayaan masyarakat di TPST Piyungan. (2)<strong> </strong>Mengetahui dampak program pemberdayaan masyarakat yang dilakukan oleh MPM di TPST Piyungan (3)<strong> </strong>Mengetahui peran dan partisipasi pemuda dalam program pemberdayaan masyarakat yang dilakukan oleh MPM di TPST Piyungan. Penelitian ini menggunakan metode kualitatif deskriptif. Hasil penelitian menunjukkan (1) Masalah yang dihadapi MPM berasal dari masyarakat sekitar yang belum mengetahui program pemberdayaan secara detail (2) Dampak yang terjadi di masyarakat adalah bersatu dalam satu komunitas yang dahulu terpencar dalam beberapa kelompok pengepul dan lebih memahami potensi diri (3) Pemuda yang tergabung dalam fasilitator pemberdayaan masyarakat berperan aktif dalam melakukan program pemberdayaan.</p>
Strategies for the Biosynthesis of Pharmaceuticals and Nutraceuticals in Microbes from Renewable Feedstock
Authors: Zhang Congqiang , Too Heng-Phon 
Published: February 2020

Backgrounds:
Abundant and renewable biomaterials serve as ideal substrates for the
sustainable production of various chemicals, including natural products (e.g., pharmaceuticals and
nutraceuticals). For decades, researchers have been focusing on how to engineer microorganisms
and developing effective fermentation processes to overproduce these molecules from biomaterials.
Despite many laboratory achievements, it remains a challenge to transform some of these into
successful industrial applications.

Results:
Here, we review recent progress in strategies and applications in metabolic engineering
for the production of natural products. Modular engineering methods, such as a multidimensional
heuristic process markedly improve efficiencies in the optimization of long and complex biosynthetic
pathways. Dynamic pathway regulation realizes autonomous adjustment and can redirect
metabolic carbon fluxes to avoid the accumulation of toxic intermediate metabolites. Microbial
co-cultivation bolsters the identification and overproduction of natural products by introducing
competition or cooperation of different species. Efflux engineering is applied to reduce product
toxicity or to overcome storage limitation and thus improves product titers and productivities.

Conclusion:
Without dispute, many of the innovative methods and strategies developed are
gradually catalyzing this transformation from the laboratory into the industry in the biosynthesis
of natural products. Sometimes, it is necessary to combine two or more strategies to acquire additive
or synergistic benefits. As such, we foresee a bright future of the biosynthesis of pharmaceuticals
and nutraceuticals in microbes from renewable biomaterials.