bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin and Evolution of Two Independently Duplicated Genes Encoding UDP- Glucose: Glycoprotein Glucosyltransferases inCaenorhabditisand Vertebrates
Authors: Caraballo Diego A , Buzzi Lucila I , Modenutti Carlos P , Acosta-Montalvo Ana , Castro Olga A , Rossi María S 
Published: December 2019

AbstractUDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences in their properties.Bayesian phylogenetic inference based on 195 UGGT and UGGT-like protein sequences of an ample spectrum of eukaryotic species showed that uggt genes went through independent duplications in Caenorhabditis and vertebrates. In both lineages, the catalytic domain of the duplicated genes was subjected to a strong purifying selective pressure, while the recognition domain was subjected to episodic positive diversifying selection. Selective relaxation in the recognition domain was more pronounced in Caenorhabditis uggt-b than in vertebrates uggt-2. Structural bioinformatics analysis revealed that Caenorhabditis UGGT-b protein lacks essential sequences proposed to be involved in the recognition of unfolded proteins. When we assayed glucosyltrasferase activity of a chimeric protein composed by Caenorhabditis uggt-b recognition domain fused to S. pombe catalytic domain expressed in yeast, no activity was detected.The present results support the conservation of the UGGT activity in the catalytic domain and a putative divergent function of the recognition domain for the UGGT2 protein in vertebrates, which would have gone through a specialization process. In Caenorhabditis, uggt-b evolved under different constraints compared to uggt-a which, by means of a putative neofunctionalization process, resulted in a non-redundant paralog. The non-canonical function of uggt-b in the worm lineage highlights the need to take precautions before generalizing gene functions in model organisms.
Book Reviews
Authors: Simpkin Sarah 
Published: December 2019

Andersson, Ruben. No Go World: How Fear is Redrawing Our Maps and Infecting Our Politics. Oakland: University of California Press, 2019. 360p. $29.95 US. ISBN 978-0-520-29460-8.
Hayes, Derek. British Columbia: A New Historical Atlas. Madeira Park, British Columbia: Douglas & McIntyre, 2019. 368p. $44.95 CAD. ISBN 978-1-77162-211-0.
Caretaking Relations, Not American Dreaming
Authors: TallBear Kim 
Published: December 2019

Rejecting the binaries of life versus not life and humans versus nature, as well as other more graduated Eurocentric hierarchies of life, I foreground an everyday Dakota understanding of existence that focuses on “being in good relation.” This analytical framework is at the center of my critique of the grand narrative of American exceptionalism. It is also translatable (not perfectly, of course) among different Indigenous traditions, and I welcome conversation with other Indigenous frameworks of relationality. Thinking in terms of being in relation, I propose an explicitly spatial narrative of caretaking relations—both human and other-than-human—as an alternative to the temporally progressive settler-colonial American Dreaming that is ever co-constituted with deadly hierarchies of life. A relational web as spatial metaphor requires us to pay attention to our relations and obligations here and now. It is a narrative that can help us resist those dreams of progress toward a never-arriving future of tolerance and good that paradoxically requires ongoing genocidal and anti-Black violence, as well as violence toward many de-animated bodies. The path toward the supposed democratic promised land of settler mythology is in everyday life a nightmare for many around the globe. American democracy not only “dies in darkness,” as the Washington Post claims. It is ever formed of hierarchical violence.
Urząd kapelana w aspekcie kanonicznym
Authors: Adamczyk Jerzy 
Published: December 2019

Celem artykułu jest ukazanie zagadnienia urzędu kapelana w aspekcie prawa kanonicznego. W jego pierwszej części przedstawiono kwestię pojęcia kapelana. W drugiej części ukazano uprawnienia i obowiązki kapelana, natomiast część trzecia została poświęcona zagadnieniu usunięcia kapelana. Całość artykułu kończy podsumowanie i bibliografia.
Grzech przeciwko VI przykazaniu Dekalogu popełniony z małoletnimi – aktualne wyzwanie kanonicznego prawa karnego Uwagi de lege ferenda w związku ze spotkaniem na szczycie w Watykanie w dniach 21–24 lutego 2019 roku*
Authors: Skonieczny Piotr 
Published: December 2019

Autor dokonuje analizy obowiązującego prawa kanonicznego w odniesieniu do przestępstw przeciwko VI przykazaniu Dekalogu z małoletnimi lub na szkodę małoletnich (art. 6 SST/2010). Wskazuje na problemy, które rodzą te przepisy. Następnie postuluje szereg zmian w kanonicznym prawie karnym w tym zakresie.
Stalinization, de-Stalinization, and re-Stalinization. 1953 behind the “Iron Curtain”
Authors: Opulski Rafał 
Published: December 2019

The aim of the article is to present the changesthattook place after the death of Joseph Stalin in 1953 in the Soviet Union and in somecountriesincluded in its “externalempire”. The “Iron Curtain”, which divided the worldintotwoparts, began to shiftafter the Generalissimo’sdeath and revealed differences in the approach of individualcountries to the „newcourse” announced by Stalin’ssuccessors.In somecountries, the death of the Kremlindictatorbeganchanges in the policy of the time, in others the methodscharacteristic of Stalinismwerecontinued, whichmeant the activity of anall-powerfulapparatus of repressionseeking real and imagined “enemies”, the central authority of unlimitedpower with mass terror and striving for totalcontrol of citizens and allmanifestations of social life. The textpresents the most importantelements of the policy of the Communistparties in the Soviet Union, GDR, Hungary, Czechoslovakia, Romania and Bulgaria in 1953 whichwereconsistent with the process of re-Stalinization, characterized by similarity to governmentsduring the dictator’s life and de-Stalinization, thatis, the reversals of methods and toolsknown in the Stalinism period.
Enslavement of the Church in Poland in 1953
Authors: Marek Łucja 
Published: December 2019

The accord entered into by and between representatives of state and Church authorities on April 14th 1950 did not protect the Catholic Church from further repression. On February 9th 1953, the State Council decreed with regard to the filling of ecclesiastical posts in the Church. Through such normative, the state authorities awarded themselves the right to interfere with the human resources aspect of religious creed. A categorical objection (Non possumus!) to this policy determined the imprisonment of the Primate Cardinal Stefan Wyszyński. The primate’s detention offered proper political conditions to engage in this and other campaigns targeting the authority, independence, and identity of the Catholic Church. The clergy’s influence on public life was restrained, and the Church was deprived of independence. It might well be assumed that were it not for events of October 1956, the Church in Poland would have been permanently subjugated to the State.
New Challenges for the Catholic Vision of the Vocation of Women and Men
Authors: Stala Józef 
Published: December 2019

At the turn of the 21st century, the ethical boundaries have been demolished in a dramatic way, especially in reference to the broadly understood human sexuality. An intensively promoted materialist anthropology connected to the reductive vision of human sexuality and sexual life, has created the foundation for anew ideology. Gender theory finds itself well in the postmodernist context, where multi-dimensional determinist conditioning, relativism and temporality of all human intellectual property are highlighted. The Traditional categories as femininity, masculinity, and heterosexuality were rejected and treated as mere archaic stereotypes. According to gender ideologists, in order to prevent discrimination one has to finally start the deconstruction of a patriarchal regime and replace it with anew, egocentric and hedonistic culture. The author of this article presents new challenges for the Catholic vision of the vocation of women and men highlighting the deconstruction of the biological sex, a new anthropology and the far-going transformations in the consciousness, social, cultural and political activity on an ­international scale.
Perspectives on the Development of Sponsorship of Catholic Ministerial Organizations with Particular Reference to Health Care
Authors: Kaleta Paweł 
Published: December 2019

Sponsorship in this paper is the formal relationship between an authorized Catholic organization and a recognized apostolic undertaking to promote and sustain Christ’s ministry to people in need. Sponsorship is not a static reality. Radical changes which have occurred in charitable works, largely due to the decline in religious vocations and the aging of members of institutes, led sponsoring leaders to seek for and find new approaches to sponsorship whereby their ministry could continue without compromising their identity. The purpose of this article is to draw attention to certain perspectives of the evolving understanding of sponsorship which is regularly in the process of being transformed and reshaped. It faces many challenges regarding the continuing Catholic identity of the sponsored works and the recognition of numerous new opportunities for future forms of sponsorship. This study explores certain canonical and practical perspectives for the development of the sponsorship of various forms of Catholic ministerial organizations, with particular reference to health care.
The Impact of Early Aggression on Late Development
Authors: Gostečnik Christian , Cvetek Robert , Pate Tanja , Poljak Lukek Saša , Simonič Barbara , Valenta Tanja , Repič Slavič Tanja 
Published: December 2019

Children who are victims of an early violent atmosphere or early relational trauma will often, even in adulthood, tend to behave violently towards others, or become victims of violence, or freeze and later develop the tendency towards self-injury, in particular in later adolescence. In adulthood, they can be accident-prone, engage in constant violent physical abuse, threaten with or actually commit suicide. In this article we will focus on the impact of violence that children experience from the earliest age, on how it affects their development, and is transmitted to adulthood as well as to younger generations, since violence is imprinted in the deepest organic fibres of every individual.
A Study of Multidimensional Submissiveness Scale
Authors: TÜRKMEN Kübra , YILDIZ Mualla 
Published: December 2019

Submissive behaviour refers to individuals’ changing their value judgments, their thoughts and their views in the direction that the authority directs to. Submissive Behavior Scale (SBS) was developed by Gilbert et al. in 1991 and was finalized in 1994 (1994: 295-306). When the scale was formed, the studies of Buss and Claik (1986) on submissive behaviours were used. The scale was adapted to Turkish by Nesrin H. Şahin and Nail Şahin in 1992. The scale, which is in the form of a questionnaire, can be administered to adolescents and adults individually or collectively. The aim of this study is to develop a new scale that can be used to assess the submissive attitude of today. In this framework, depending on the intensities (frequency of behaviours) resulting from the data to be obtained, the dimensions of the submissive attitude will be identified. It was planned to determine which elements in individuals’ submission levels played a major role through this scale. First, exploratory factor analysis was used to describe subscales and a four-dimensional scale (N1=368) was developed. Four factors explained 52.82% of the total variance. Then the scale was applied to another sample (N2=457) for confirmatory factor analysis. The score was 266.49 (df= 98) with the ratio having a value of 2.72.The goodness of fit indexes are CFI=0.93; GFI=0.93; NFI=0.90; RMSEA=0.061. These values indicate that the four-factor structure of the scale have a reasonably satisfactory goodness of fit. A significant and positive correlation between Multidimensional Submissiveness Scale and Submissive Behaviour Scale was observed. Finally, it was found that Multidimensional Submissiveness Scale is a reliable and valid measure and can be a helpful measure for the researcher to understand submissive behaviours.
Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy
Authors: Schwartzberg Lee , Navari Rudolph , Clark-Snow Rebecca , Arkania Ekaterine , Radyukova Irena , Patel Kamal , Voisin Daniel , Rizzi Giada , Wickham Rita , Gralla Richard J. , Aapro Matti , Roeland Eric 
Published: December 2019

Abstract

Background
NEPA, a combination antiemetic of a neurokinin-1 (NK1) receptor antagonist (RA) (netupitant [oral]/fosnetupitant [intravenous; IV]) and 5-HT3RA, palonosetron] offers 5-day CINV prevention with a single dose. Fosnetupitant solution contains no allergenic excipients, surfactant, emulsifier, or solubility enhancer. A phase III study of patients receiving cisplatin found no infusion-site or anaphylactic reactions related to IV NEPA. However, hypersensitivity reactions and anaphylaxis have been reported with other IV NK1RAs, particularly fosaprepitant in patients receiving anthracycline-cyclophosphamide (AC)-based chemotherapy. This study evaluated the safety and efficacy of IV NEPA in the AC setting.

Materials and Methods
This phase IIIb, multinational, randomized, double-blind study enrolled females with breast cancer naive to highly or moderately emetogenic chemotherapy. Patients were randomized to receive a single 30-minute infusion of IV NEPA or single oral NEPA capsule on day 1 prior to AC, in repeated (up to 4) cycles. Oral dexamethasone was given to all patients on day 1 only.

Results
A total of 402 patients were included. The adverse event (AE) profiles were similar for IV and oral NEPA and consistent with those expected. Most AEs were mild or moderate with a similarly low incidence of treatment-related AEs in both groups. There were no treatment-related injection-site AEs and no reports of hypersensitivity or anaphylaxis. The efficacy of IV and oral NEPA were similar, with high complete response (no emesis/no rescue) rates observed in cycle 1 (overall [0–120 hours] 73.0% IV NEPA, 77.3% oral NEPA) and maintained over subsequent cycles.

Conclusion
IV NEPA was highly effective and safe with no associated hypersensitivity and injection-site reactions in patients receiving AC.
THE ATTITUDE OF UNIVERSITY STUDENTS TOWARDS CELEBRITY ENDORSEMENTS THROUGH SOCIAL MEDIA
Authors: Alshetti Ahmed , Al Mubarak Muneer 
Published: December 2019

Purpose of the study: The study aims to identify the factors that influence students’ attitudes when celebrity endorsements are used through social media. It seeks to determine how effective endorsements are from the consumers’ point of view.
Methodology: A study model was developed to show the effect of different factors on students’ attitudes. A quantitative approach was used for data collection to support the model. This study employed a survey method using a questionnaire to gather information from participants.
Main findings: The findings show celebrity characteristics and social media advertisements affect students’ attitudes. The results were positive for students’ attitude towards celebrity endorsements through social media.
Applications of the study: The study provides insights into how businesses should plan marketing campaigns and influence students’ attitudes towards celebrity endorsements through social media. Companies are encouraged to use social networks to track and respond to the opinions of their customers in a timely manner.
Novelty/Originality of this study: There is a shortage of literature that is associated with celebrity endorsements through social media. This study aims to fill in the gap in knowledge and practice by identifying business opportunities and optimizing available marketing tools that can be used in order to gain a better image.
The Synthesis of New Phosphazene-Bearing Ethyl p-Hydroxybenzoate and Ferrocenyl Pendant Groups and their Spectroscopic and Crystallographic Characterizations
Authors: TÜMER Yasemin , ÇAYIRBAŞI Mahmut , ŞAHİN Onur , HÖKELEK Tuncer 
Published: December 2019

Herein, we
report a study of novel hexachlorocyclotriphosphazene (N3P3Cl6)
derivatives bearing ethyl p-hydroxy benzoate
and pendant ferrocenyl groups. Characterizations of the products [mono- 2, di- (geminal 3a; non-geminal transa-3b, transb-3c and cis-3d), tri- 4 and tetra-
5
substitue phosphazene derivatives] were performed using elemental analysis and spectral methods. The structure
of the two compounds (2 and 5) are
elucidated by X-ray diffraction techniques.
On the Local Adjacency Metric Dimension of Generalized Petersen Graphs
Authors: Marsidi Marsidi , Dafik Dafik , Agustin Ika Hesti , Alfarisi Ridho 
Published: December 2019

The local adjacency metric dimension is one of graph topic. Suppose there are three neighboring vertex , , in path . Path is called local if where each has representation: a is not equals and may equals to . Let’s say, . For an order set of vertices , the adjacency representation of with respect to is the ordered -tuple , where represents the adjacency distance . The distance defined by 0 if , 1 if adjacent with , and 2 if does not adjacent with . The set is a local adjacency resolving set of if for every two distinct vertices , and adjacent with y then . A minimum local adjacency resolving set in is called local adjacency metric basis. The cardinality of vertices in the basis is a local adjacency metric dimension of , denoted by . Next, we investigate the local adjacency metric dimension of generalized petersen graph.
De novo sequencing of the transcriptome of Fargesia macclureana (Poaceae) reveals regulators of the floral transition and ecological adaptations to high altitude
Authors: Li Ying , Zhang Chunxia , Yang Kebin , Shi Jingjing , Ding Yulong , Gao Zhimin 
Published: December 2019

Abstract
Background: Fargesia macclureana (Poaceae) is a woody bamboo species found on the Qinghai–Tibet Plateau (QTP) approximately 2,000 ~ 3,800 m above sea level. It rarely blossoms in the QTP, but it flowered 20 days after growing in our lab, which is in a low-altitude area outside the QTP. To date, little is known regarding the molecular mechanism of bamboo flowering, and no studies of flowering have been conducted on wild bamboo plants growing in extreme environments. Here, we report the first de novo transcriptome sequence for F. macclureana to investigate the putative mechanisms underlying the flowering time control used by F. macclureana to adapt to its environment. Results: Illumina deep sequencing of the F. macclureana transcriptome generated 140.94 Gb of data, assembled into 99,056 unigenes. A comprehensive analysis of the broadly, specifically and differentially expressed unigenes (BEUs, SEUs and DEUs) indicated that they were mostly involved in metabolism and signal transduction, as well as DNA repair and plant-pathogen interactions, which may be of adaptive importance. In addition, comparison analysis between non-flowering and flowering tissues revealed that expressions of FmFT and FmHd3a, two putative F. macclureana orthologs, were differently regulated in NF- vs F- leaves, and carbohydrate metabolism and signal transduction were two major KEGG pathways that DEUs were enriched in. Finally, we detected 9,296 simple sequence repeats (SSRs) that may be useful for further molecular marker-assisted breeding. Conclusions: F. macclureana may have evolved specific reproductive strategies for flowering-related pathways in response to photoperiodic cues to ensure long vegetation growing period. Our findings will provide new insights to future investigations into the mechanisms of flowering time control and adaptive evolution in plants growing at high altitudes.
Metabolite profile comparison of a graft chimera ‘Hongrou Huyou’ (Citrus changshan-huyou + Citrus unshiu) and its two donor plants
Authors: Zhang Min , Jing Luyang , Wu Qun , Zhu Kaijie , Ke Fuzhi , Xu Jianguo , Zhao Siqing , Wang Gang , Zhang Chi 
Published: December 2019

Abstract
Background: Chimeras synthesized artificially by grafting are crucial to the breeding of perennial woody plants. ‘Hongrou Huyou’ (Citrus changshan-huyou + Citrus unshiu) is a new graft chimera originating from the junction where a Citrus changshan-huyou (“C”) scion was top-grafted onto a stock Satsuma mandarin ‘Owari’ (C. unshiu, “O”). The chimera was named OCC because the cell layer constitutions were O for Layer 1(L1) and C for L2 and L3. In this study, profiles of primary metabolites, volatiles and carotenoids derived from different tissues in OCC and the two donors were investigated, with the aim of determining the relationship between the layer donors and metabolites.
Results: The comparison of the metabolite profiles showed that the amount and composition of metabolites were different between the peels and the juice sacs, as well as between OCC and each of the two donors. The absence or presence of specific metabolites (such as the carotenoids violaxanthin and β-cryptoxanthin, the volatile hydrocarbon germacrene D, and the primary metabolites citric acid and sorbose) in each tissue was identified in the three phenotypes. According to principal component analysis (PCA), overall, the metabolites in the peel of the chimera were derived from donor C, whereas those in the juice sac of the chimera came from donor O.
Conclusion: The profiles of primary metabolites, volatiles and carotenoids derived from the peels and juice sacs of OCC and the two donors were systematically compared. The content and composition of metabolites were different between the tissues and between OCC and the each of the two donors. A clear donor dominant pattern of metabolite inheritance was observed in the different tissues of OCC and was basically consistent with the layer origin; the peel of the chimera was derived from C, and the juice sacs of the chimera came from O. These profiles provide potential chemical markers for genotype differentiation, citrus breeding assessment, and donor selection during artificial chimera synthesis.