bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose-Dependent Effect of Platinum-Based Chemotherapy on the Risk of Metachronous Contralateral Testicular Cancer
Authors: Blok Joost M. , Groot Harmke J. , Huele Eline H. , de Wit Ronald , Horenblas Simon , Nuver Janine , Groenewegen Gerard , Bosch J.L.H. Ruud , Witjes J. Alfred , Tromp Jacqueline M. , de Brouwer Peter J.M. , van den Berg Hetty A. , Vanneste Ben G.L. , Smilde Tineke J. , Aarts Maureen J.B. , Gietema Jourik A. , Meijer Richard P. , Schaapveld Michael 
Published: October 2020

PURPOSE Patients with testicular germ cell tumor (TGCT) are at increased risk of developing a contralateral TGCT (CTGCT). Although some studies suggest that prior treatment with platinum-based chemotherapy affects CTGCT risk, a relationship between CTGCT risk and platinum dose has not previously been assessed. We analyzed the association between the number of platinum-based chemotherapy cycles and CTGCT risk. PATIENTS AND METHODS The risk of developing a metachronous CTGCT was evaluated in a nationwide cohort of 4,755 patients diagnosed with primary TGCT in the Netherlands between 1989 and 2007. Standardized incidence ratios were computed to compare CTGCT incidence with expected TGCT on the basis of TGCT incidence in the general population. The cumulative incidence of CTGCT was estimated in the presence of death as competing risk. The effect of treatment with platinum-based chemotherapy on CTGCT risk was assessed using multivariable Cox proportional hazards regression models. RESULTS CTGCT was diagnosed in 136 patients (standardized incidence ratio, 14.6; 95% CI, 12.2 to 17.2). The cumulative incidence increased up to 20 years after primary diagnosis, reaching 3.4% (95% CI, 2.8% to 4.0%) after 20 years of follow up. The risk of developing a CTGCT decreased with age (hazard ratio [HR], 0.93; 95% CI, 0.90 to 0.96), was lower after nonseminomatous germ cell tumor (HR, 0.58; 95% CI, 0.35 to 0.96) and decreased with every additional cycle of chemotherapy (HRper cycle, 0.74; 95% CI, 0.64 to 0.85). CONCLUSION Approximately one in every 30 survivors of TGCT will develop a CTGCT, with CTGCT incidence increasing up to 20 years after a primary TGCT. Treatment with platinum-based chemotherapy shows a dose-dependent inverse association with CTGCT risk.
SARS-CoV-2 (COVID-19) and the Endocrine System
Authors: Lundholm Michelle D , Poku Caroline , Emanuele Nicholas , Emanuele Mary Ann , Lopez Norma 
Published: October 2020

AbstractAs SARS-CoV-2 (COVID-19) overtakes the world, causing moderate to severe disease in about 15% of infected patients, COVID-19 is also found to have widespread effects throughout the body with a myriad of clinical manifestations including the endocrine system. This manuscript reviews what is known about the impact of COVID-19 on the pathophysiology and management of diabetes (both outpatient and inpatient) as well as pituitary, adrenal, thyroid, bone, and gonadal function. Findings in this area are evolving, and long-term effects of infection remain an active area of further research.
Metabolic Effects of Cortisone Acetate vs Hydrocortisone in Patients With Secondary Adrenal Insufficiency
Authors: Ekstrand Elise , Esposito Daniela , Ragnarsson Oskar , Isgaard Jörgen , Johannsson Gudmundur 
Published: October 2020

AbstractContextPharmacokinetic properties of cortisone acetate (CA) and hydrocortisone (HC) differ because CA needs to be converted into cortisol to become active.ObjectiveThis work analyzed the metabolic consequences of switching CA to an equivalent daily dose of HC in patients with secondary adrenal insufficiency (SAI).DesignThis was a post hoc analysis from a prospective study including individuals with hypopituitarism receiving growth hormone replacement. Data were collected before and after a switch from CA to an equivalent dose of HC (switch group). Two control groups were included: patients continuing CA replacement (CA control group) and adrenal-sufficient hypopituitary patients (AS control group).ResultsThe analysis included 229 patients: 105, 31, and 93 in the switch, CA control, and AS control groups, respectively. After the change from CA to HC, increases in mean body weight (1.2 kg; P &lt; .05), waist circumference (2.9 cm; P &lt; .001), body fat measured by dual-energy x-ray absorptiometry (1.3 kg; P &lt; .001), and glycated hemoglobin (0.3%; P &lt; .05) were recorded in the switch group. The increase in mean waist circumference was greater than in the AS control group (0.9 cm; P &lt; .05). Mean body fat increased in the switch group but not in the CA control group (–0.7 kg; P &lt; .05).ConclusionsA switch from CA to an equivalent dose of HC was associated with a worsened metabolic profile, suggesting that HC has a more powerful metabolic action than CA based on the assumption that 20 mg HC equals 25 mg CA.
Alterlivability
Authors: Hamraie Aimi 
Published: October 2020

AbstractThis article responds to two diverging notions of “livability”: the normative New Urbanist imaginary of livable cities, where the urban good life manifests in neoliberal consumer cultures, green gentrification, and inaccessible infrastructures, and the feminist and disability concept of livable worlds, such as those in which nonnormate life thrives. Whereas the former ought to broaden its notion of “lives worth living,” the latter would benefit from a more specific theory of design—the making and remaking of more livable worlds. In response, this article offers the concept of “alterlivability,” a design philosophy grounded in permaculture ethics. Drawing on two novels by ecofeminist writer Starhawk—The Fifth Sacred Thing (1994) and City of Refuge (2016)—the article explores the genre of speculative design fiction for its insights into prototyping more livable futures in the Anthropocene. Starhawk’s novels illustrate alterlivability as a set of political commitments, design methodologies, and spatial forms that place disabled, racialized, and poor people at the center of alterlivable worlds.
Dear Trans Studies, Can You Do Love?
Authors: Ellasante Ian Khara 
Published: October 2020

Abstract
This essay considers the origins, intentions, and potential of transgender studies. As the field becomes increasingly institutionalized, is transgender studies capable of honoring the embodied knowledges from which it originates and, if so, how? The author suggests orientations that foreground the relevance, reciprocity, and accessibility of transgender studies for the very people whose lives and experiences the field transmutes into scholarship. The author draws from Dora Silva Santana's papo-de-mano and escrevivência and Kai M. Green and Treva Ellison's “tranifesting”—approaches that demonstrate that, in fact, transgender studies can do redress, tenderness, and love in the service of both knowledge production and resistance.
Celebrating the Launch of the Lili Elbe Digital Archive
Authors: Caughie Pamela L. , Datskou Emily 
Published: October 2020

Abstract
This article describes the launch symposium of the Lili Elbe Digital Archive held at Loyola University Chicago in February 2020. The Lili Elbe Digital Archive presents the life narrative of Lili Elbe, one of the most iconic figures in the history of gender variance, along with supplementary materials such as letters and newspaper articles. The symposium offered a queer-friendly, trans-inclusive space where trans, queer, and cisgender scholars and students across disciplines, universities, and generations came together to commemorate Lili's life and the work of the archive. This review examines the transfeminist pedagogy of the archive team and the symposium.
Cutting Up Words
Authors: Bey Marquis 
Published: October 2020

Abstract
This article argues that Kathy Acker articulates an understanding of transness through language. More than a meditation on gender-nonnormative characters in Acker's work, the article dwells on how Acker uses language as a vector through which to imply the residue of a certain understanding of trans. In short, examined here is Acker as a trans philosophical thinker, one whose thinking manifested in how she uses language.
Synthesis, Characterization and Properties of Solid Waste Based High Belite Cement
Authors: Gao Yifan , Li Zhaofeng , Zhang Jian , Zhang Chen , Chen Jingpeng 
Published: October 2020

Abstract
To alleviate pressure on natural resources and solve the environmental problem of solid waste, we recognized the urgency of finding a substitute for belite cement raw materials, and synthesized a belite cement from solid waste. The results show that the belite cement can be successfully prepared by calcinating carbide slag, silica fume, and red mud; The Ca2+ in the mineral crystal structure can be replaced by other ions in solid waste; Long-term strength is higher than ordinary Portland cement.
Undisclosed SEC Investigations
Authors: Blackburne Terrence , Kepler John D. , Quinn Phillip J. , Taylor Daniel 
Published: October 2020

One of the hallmarks of the Security and Exchange Commision's (SEC's) investigative process is that it is shrouded in secrecy—only the SEC staff, high-level managers of the company being investigated, and outside counsel are typically aware of active investigations. We obtain novel data on all investigations closed by the SEC between 2000 and 2017—data that were heretofore nonpublic—and find that such investigations predict economically material declines in future firm performance. Despite evidence that the vast majority of these investigations are economically material, firms are not required to disclose them, and only 19% of investigations are initially disclosed. We examine whether corporate insiders exploit the undisclosed nature of these investigations for personal gain. Despite the undisclosed and economically material nature of these investigations, we find that insiders are not abstaining from trading. In particular, we find a pronounced spike in insider selling among undisclosed investigations with the most severe negative outcomes; and that abnormal selling activity appears highly opportunistic and earns significant abnormal returns. Our results suggest that SEC investigations are often undisclosed, economically material nonpublic events, and that insiders are trading in conjunction with these events. This paper was accepted by Suraj Srinivasan, accounting.
Two-photon cross-section calculations for krypton in the 190–220  nm range
Authors: Shekhtman David , Mustafa Muhammad Ammar , Parziale Nicholaus Joseph 
Published: October 2020

This paper presents multi-path, two-photon excitation cross-section calculations for krypton, using first-order perturbation theory. For evaluation of the two-photon-transition matrix element, this paper formulates the two-photon cross-section calculation as a matrix mechanics problem. From a finite basis of states, consisting of

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orbitals, electric dipole matrix elements are constructed, and a Green’s function is expressed as a truncated, spectral expansion of solutions, satisfying the Schrödinger equation. Electric dipole matrix elements are evaluated via tabulated oscillator strengths, and where those are unavailable, quantum-defect theory is used. The relative magnitudes of two-photon cross-sections for eight krypton lines in the 190–220 nm range are compared to experimental excitation spectra with good agreement. This work provides fundamental physical understanding of the Kr atom, which adds to experimental observations of relative fluorescence intensity. This is valuable when comparing excitation schemes in different environments for krypton fluorescence experiments. We conclude that two-photon excitation at 212.556 nm is optimal for single-laser, krypton tagging velocimetry or krypton planar laser-induced fluorescence.
Ottoman Dress and Design in the West: A Visual History of Cultural Exchange, C. A. Jirousek (2019)
Authors: Alimen Nazlı 
Published: October 2020

Review of: Ottoman Dress and Design in the West: A Visual History of Cultural Exchange, C. A. Jirousek (2019)
Bloomington, IN: Indiana University Press, 272 pp.,
ISBN 978-0-25304-216-3, p/bk, $32.00,
ISBN 978-0-25304-218-7, e-book, $18.99
Transitando entre la guerra, la pluma y la nobleza a través de intendentes del despotismo ilustrado español
Authors: Coll Coll Ana María 
Published: October 2020

El siglo XVIII es definible como el siglo de las paradojas, de los avances y de las permanencias. Este trabajo quiere ejemplificar este último trinomio en el ámbito de la carrera administrativa de los intendentes que ejercieron en Mallorca durante el reinado de Carlos IV, sin dejar de observar algunos perfiles de los reinados anteriores. La implicación de parte de estos hombres en proyectos de fomento y de mejora de la economía, ajustándose a los designios de la Corte, así como su propia formación e incluso su producción escrita, contrastan con los perfiles vistos a inicios del siglo XVIII. Sin embargo, todo ello suele verse cegado por su desvivir por la nobleza, por el valor dado a los méritos de guerra, y por unas ansias de consecución de un mejor rango social que incluyen el uso de fórmulas clásicas como son el linaje, la familia o el clientelismo. Asimismo, un estudio de caso, el de Miguel Bañuelos, escenifica como ninguno este siglo de coexistencias.
Pronera e a produção do conhecimento na formação de educadores e nas ciências agrárias: teoria e prática no enfrentamento ao bolsonarismo
Authors: Molina Monica Castagna , Santos Clarice Aparecida dos , Brito Márcia Mariana Bittencourt 
Published: October 2020

Os direitos do campesinato têm sido alvo constante de ataques do bolsonarismo. Parte desses ataques pretende destruir o Programa Nacional de Educação na Reforma Agraria (Pronera). Cogita-se que essa tentativa associa-se aos resultados produzidos pelo Pronera, que caminham em direção contrária aos interesses político-econômicos que sustentam o bolsonarismo. Este artigo objetiva refletir sobre possíveis diferenciais nos processos de produção do conhecimento gerados nos cursos superiores vinculados ao Pronera, na Formação de Educadores e nas Ciências Agrárias, e sobre as potencialidades desse processo para intervir na transformação da realidade social, contribuindo com a materialização do projeto territorial camponês, centrado na desconcentração fundiária, agroecologia e soberania alimentar. Foram analisados relatórios da II Pesquisa Nacional de Educação na Reforma Agrária e realizada pesquisa bibliográfica no Catálogo de Teses da Capes, entre 1998 e 2019. Localizaram-se 48 pesquisas sobre formação de educadores e 24 sobre Ciências Agrárias, vinculadas ao Pronera. Após leitura dos resumos e conclusões, priorizou-se a análise de pesquisas sobre a atuação dos egressos nas escolas (12 trabalhos) e na organização da produção dos assentamentos (5 trabalhos), intencionando captar a relação entre a teoria e a prática promovida por tais processos formativos. As pesquisas encontraram relevante inserção dos egressos nas escolas dos assentamentos, com alterações em sua organização escolar e trabalho pedagógico, além de mudanças nos processos produtivos em direção à transição agroecológica em assentamentos onde atuam egressos das Ciências Agrárias, apontando a existência de um processo de produção do conhecimento diferenciado nos cursos vinculados às lutas sociais para transformação do campo.
Formação de professores do campo frente às “novas/velhas” políticas implementadas no Brasil: r-existência em debate
Authors: Do Socorro de Araújo Silva Hellen , Pereira dos Anjos Maura , Castagna Molina Mônica , Antônio Mufarrej Hage Salomão 
Published: October 2020

As reflexões apresentadas neste artigo integram parte dos resultados produzidos pela pesquisa “Políticas, Gestão e Direito à Educação Superior: novos modos de Regulação e tendências em construção”, ligada à Rede Universitas-Br, desenvolvida pelo Eixo Temático 7, cuja investigação centra-se na Educação Superior do Campo. O artigo traz análises sobre as políticas de formação docente, com foco nos retrocessos impostos a tais políticas, especialmente às Licenciaturas em Educação do Campo, a partir da aprovação das “novas” Diretrizes Curriculares Nacionais para a Formação Inicial de Professores para a Educação Básica e a instituição da Base Nacional Comum para a Formação Inicial de Professores da Educação Básica. O método da pesquisa se ancora no materialismo histórico e dialético por meio das categorias totalidade, historicidade e mediação no campo das políticas de formação de professores no Brasil. Realizou-se estudos bibliográficos das Resoluções Nº 02/2015 e Nº 02/2019 e dos manifestos das entidades científicas nacionais da formação docente. Os resultados revelam desmontes e retrocessos no campo das políticas de formação de professores, com a disseminação da pedagogia das competências na aprovação da Resolução Nº 2/2019, que buscam deslegitimar a implementação de projetos críticos e emancipatórios no campo da formação inicial e continuada de professores. O Ministério da Educação e o Conselho Nacional de Educação tomam medidas que desconstroem políticas direcionadas aos sujeitos do campo, indígenas e quilombolas e ameaçam a continuidade dos cursos de Licenciatura em Educação do Campo, o que provoca uma r-existência dos sujeitos diversos e plurais na garantia de seus direitos.
The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals
Authors: Barkai Omer , Butterman Rachely , Katz Ben , Lev Shaya , Binshtok Alexander M. 
Published: October 2020

The output from the peripheral terminals of primary nociceptive neurons, which detect and encode the information regarding noxious stimuli, is crucial in determining pain sensation. The nociceptive terminal endings are morphologically complex structures assembled from multiple branches of different geometry, which converge in a variety of forms to create the terminal tree. The output of a single terminal is defined by the properties of the transducer channels producing the generation potentials and voltage-gated channels, translating the generation potentials into action potential (AP) firing. However, in the majority of cases, noxious stimuli activate multiple terminals; thus, the output of the nociceptive neuron is defined by the integration and computation of the inputs of the individual terminals. Here, we used a computational model of nociceptive terminal tree to study how the architecture of the terminal tree affects the input-output relation of the primary nociceptive neurons. We show that the input-output properties of the nociceptive neurons depend on the length, the axial resistance (Ra), and location of individual terminals. Moreover, we show that activation of multiple terminals by a capsaicin-like current allows summation of the responses from individual terminals, thus leading to increased nociceptive output. Stimulation of the terminals in simulated models of inflammatory or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, emphasizing the role of temporal code in conveying key information about changes in nociceptive output in pathologic conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENTNoxious stimuli are detected by terminal endings of primary nociceptive neurons, which are organized into morphologically complex terminal trees. The information from multiple terminals is integrated along the terminal tree, computing the neuronal output, which propagates toward the CNS, thus shaping the pain sensation. Here, we revealed that the structure of the nociceptive terminal tree determines the output of nociceptive neurons. We show that the integration of noxious information depends on the morphology of the terminal trees and how this integration and, consequently, the neuronal output change under pathologic conditions. Our findings help to predict how nociceptive neurons encode noxious stimuli and how this encoding changes in pathologic conditions, leading to pain.
Does Family History of Cancer Influence Undergoing Screening and Gastrointestinal Investigations?
Authors: Razuka-Ebela Danute , Zile Irisa , Tzivian Lilian , Ebela Inguna , Polaka Inese , Parshutin Sergei , Santare Daiga , Murillo Raul , Herrero Rolando , Young Park Jin , Leja Marcis 
Published: October 2020

Background and Aims: Although a family history of cancer (FHC) can modify the lifestyle and attitudes towards participation in cancer screening programs, studies on this relationship show mixed results and vary across populations. The objectives of the study were to compare sociodemographic characteristics, history of gastrointestinal (GI) investigations and Helicobacter pylori eradication, and modifiable cancer risk factors between those with FHC and those with no FHC (NFHC), and to investigate the association between FHC and a history of GI investigations.
Methods: A total of 3,455 questionnaires from the pilot study of the “Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (GISTAR study)” in Latvia were analysed. We compared sociodemographic characteristics and history of GI investigations between participants with self- reported FHC and NFHC. Binary logistic regression models adjusted for socio-demographic characteristics and modifiable cancer risk factors were built for a FHC and each GI investigation.
Results: Participants with a FHC were more likely to be women, have a higher education and less likely to have harmful habits (smoking, alcohol consumption) than those with NFHC. Participants with a FHC were approximately twice as likely to report recent colorectal investigations specifically for screening, than those with NFHC. In fully adjusted logistic regression models, FHC was significantly associated with a recent history of faecal occult blood tests (FOBTs), colonoscopies, and colorectal investigations (FOBT or colonoscopy) specifically for screening as part of the national organized screening programme.
Conclusion. Our results indicate that those with a FHC have different patterns of health-related behaviour than those with NFHC.
Ångström- and Nano-scale Pore-Based Nucleic Acid Sequencing of Current and Emergent Pathogens
Authors: Shepherd Britney A. , Tanjil Md Rubayat-E , Jeong Yunjo , Baloğlu Bilgenur , Liao Jingqiu , Wang Michael Cai 
Published: October 2020

AbstractState-of-the-art nanopore sequencing enables rapid and real-time identification of novel pathogens, which has wide application in various research areas and is an emerging diagnostic tool for infectious diseases including COVID-19. Nanopore translocation enables de novo sequencing with long reads (> 10 kb) of novel genomes, which has advantages over existing short-read sequencing technologies. Biological nanopore sequencing has already achieved success as a technology platform but it is sensitive to empirical factors such as pH and temperature. Alternatively, ångström- and nano-scale solid-state nanopores, especially those based on two-dimensional (2D) membranes, are promising next-generation technologies as they can surpass biological nanopores in the variety of membrane materials, ease of defining pore morphology, higher nucleotide detection sensitivity, and facilitation of novel and hybrid sequencing modalities. Since the discovery of graphene, atomically-thin 2D materials have shown immense potential for the fabrication of nanopores with well-defined geometry, rendering them viable candidates for nanopore sequencing membranes. Here, we review recent progress and future development trends of 2D materials and their ångström- and nano-scale pore-based nucleic acid (NA) sequencing including fabrication techniques and current and emerging sequencing modalities. In addition, we discuss the current challenges of translocation-based nanopore sequencing and provide an outlook on promising future research directions.