bluuebunny/crossref_metadata_2025_split huggingface dataset:
MINIMALLY INVASIVE AORTIC VALVE SURGERY WITH VENOUS WALL-LESS CANNULAS: PERFORMANCES AND SAFETY PROFILE
Authors: Torre T. , Pozzoli A. , Schraemli M. , Toto F. , Muretti M. , Demertzis S. , Ferrari E. 
Published: December 2024

Introduction:
Techniques for venous cannulation during aortic minimally invasive surgery (MICS) evolved significantly. Aim of this study is to report the institutional experience with virtually wall-less venous cannulas during MICS aortic surgery.

Methods:
Transfemoral venous cannulation with Smart cannulas was performed in consecutive patients undergoing aortic MICS (isolated or in combination with other procedures). Target venous flow drainage (2.4 L/mq, Cardiac Index) and maximal suction performance without vacuum assistance were measured along with complications.

Results:
Since 2017, the Smartcannula was successfully positioned in all 75 patients (65.3 ± 11.8 years, 56 males) undergoing aortic MICS. The size measured 680 mm in length was adopted in all but two patients, who received the 530 mm Smartcannula. Regarding the surgical access, it was a superior mini-sternotomy in 75 patients (57 AVR, 10 bio-Bentall, 8 isolated ascending aorta and hemi-arch replacement). For a body height of 169.22 ± 24.83 cm and a body weight of 80.55 ± 15.21 kg, the calculated body surface area was 1.93 ± 0.22 mq. Expected target flow of 4.63 ± 0.53, whereas the achieved flow accounted for 5.85 ± 0.88 l/min (increase of 19.79%, in respect to target flow) without adopting vacuum, in all cases.

Conclusion:
The performance of self-expanding smart cannulas for venous drainage during aortic MICS proved to be extremely satisfactory, with a high safety profile. The drainage is optimal without vacuum in this setting, suggesting a steady superior flow over traditional rigid wall cannulas and confirming the efficacy during their routinary use.
RECONSTRUCTION OF LEFT VENTRICLE OUTFLOW TRACT AFTER ENDOCARDITIS: HOW WE DO IT
Authors: Ballan G. , Pantaleo A. , Calcara G. B. , Guerra G. , Cavicchiolo A. G. , Minniti G. 
Published: December 2024

Backgrounds and aim:
One of the most widely adopted and complex procedures to treat Infective Endocarditis (IE) is the Commando technique. We propose a retrospective survival analysis with a different procedure performed in our center: the reconstruction of the whole left ventricle outflow tract (LVOT) with a pericardial cylindrical patch.

Methods:
We selected patients admitted from 2004 to 2023. Cases had LVOT or aortic root abscess, both on native or prosthetic valves with or without mitral valve involvement. We focused on aortic clamp time, cardiopulmonary bypass time, overall survival (OS) and event free survival (EFS).

Results:
We found 80 consecutive patients. Mean age at surgery was 63 years old. Sixty-one percent had already required heart surgery. Prosthetic valve involvement was found in 52% of the population. At the time of the procedure, the average EF was 58%. Mean aortic-clamp time was 145,2 minutes and the average cardiopulmonary bypass time was 188,6 minutes. One-year OS and EFS was respectively 78,75% and 98,75%. Only 2 patients (1,6%) needed additional heart surgery in the first year after the procedure.

Conclusions:
The literature reports for Commando and hemi-Commando technique a cardiopulmonary bypass time of 250 minutes and an aortic-clamp time of 200 minutes, which are both longer than those reported in our experience. One year OS, EFS and reintervention rates are comparable to the available data in literature. This study has some limitations, still it would be worthy of further prospective case-control study to validate this less demolitive and apparently equally effective technique.
SURGICAL TREATMENT OF BENIGN CARDIAC TUMORS: A 33-YEAR SINGLE-CENTER EXPERIENCE.
Authors: Buttiglione G. , Garatti A. , Gastino E. , Scarpanti M. , Canziani A. , Daprati A. , De Vincentiis C. , Parolari A. , Menicanti L. 
Published: December 2024

Background:
Primary cardiac tumors are extremely uncommon and the majority (80%) can be classified as benign. Myxoma is the most common histotype accounting for 50% of benign cardiac tumors (BCT). This study aims to present our 33-year experience in treating benign cardiac tumors, describing their epidemiological characteristics, and the surgical outcome for each specific subtype.

Methods:
Between January 1990 and December 2023, 176 patients (73 males, mean age 63±10 years) with benign cardiac tumors underwent surgery. We performed a retrospective analysis of the three most common benign subtype: solid myxomas, papillary myxomas and fibro-elastomas. Tumors were detected through Echocardiogram, CT scan and magnetic resonance imaging (MRI). Long-term survival and freedom from tumor recurrence were assessed with Kaplan- Meier analysis.

Results:
Among clinical presentations, most patients were asymptomatic (55%), while Heart failure (HF) symptoms were evident in 26% of patients, especially if presenting with solid myxomas. The most common origin site of myxomas was the left atrium (74%). All patients had complete excision and 31% underwent combined procedures. Postoperative complications were similar in all tumor subtypes, except for stroke which was significantly higher in papillary myxoma and fibroelastoma type. Overall 30-day mortality was 1.7%, without any differences among study groups. Overall cumulative survival showed no significant differences among tumor subtypes. Myxomas showed no significant long-term recurrence, while fibroelastoma showed a 10% recurrence at 20 years.

Conclusions:
In our experience, complete surgical excision is the gold standard therapy for benign cardiac tumors, with excellent short and long-term outcomes regardless of tumor type.
EARLY RESULTS OF TOTALLY ENDOSCOPIC AORTIC VALVE SURGERY IN TAVI-AGE POPULATION
Authors: Zoni D. , Cresce G. D. , Tropea I. , Sanesi V. , Salvador L. 
Published: December 2024

Background and Aim:
From EACTS guidelines, TAVI is preferred treatment choice in specific population’s characteristic, age is the major factor in TAVI favour. Study’s aim is to evaluate if Totally Endoscopic Aortic Valve Surgery (EAVS) has satisfactory early results in TAVI-Age population

Methods:
We performed a retrospective, single-center study of all patients undergone Totally EAVS from April 2014 to August 2024. Inclusion criteria were age > 18 y.o., totally endoscopic approach, AV surgery with or without concomitant procedure. Patient were stratified by age (18 – 74 years, > 75 years). Multivariable regression analysis was used to evaluate early outcomes.

Results:
577 patients undergone Totally EAVS, 447 (77.5%) were in the 18-74 years group, 130 (22.5%) in the > 75 years group. Regression analysis was adjusted for confounders. Before adjustment the 18 -74 y.o. population had lower hospitalization stay (medians days) (5 vs 6, p=0.003), all cause mortality (0.5% vs 4.4%, p=0.01), stroke (0.8% vs 4.5%, p=0.045), pacemaker implantation (2.9% vs 9.1%, p=0.01), ICU time (medians, hours) (24 vs 37, p=0.001). After adjustment 30-day mortality (OR 5.38, p=0.17), hospitalizations stay (beta - 0.29, p=0.71), ICU time (beta -0.24, p=0.98) did not differ. Pace-maker implantation (OR 2.66, p=0.08) and stroke (OR 4.86, p=0.06) were close to statistical significance.

Conclusions:
Totally EAVS in > 75 y.o. population had no difference in ICU time, hospital stay, mortality. A closely significant higher risk of stroke and pace-maker implantation was noted. Totally EAVS in TAVI-Age population has satisfactory early results and could be considered as alternative approach.
Analysis and Prediction of Consumer Decision-making Process of Live Broadcast Marketing under the Background of Digital Economy
Authors: Xu Yingzi 
Published: December 2024

Abstract
Under the background of digital economy, live broadcast marketing has become an important marketing method in the era of digital economy because of its high interactivity, real-time communication effect and accurate user positioning. Based on this, this paper puts forward four research hypotheses, that is, the quality of live broadcast content, the personal charm of anchor, the interaction between live broadcasts and the live broadcast preferential activities all have a positive impact on consumers’ purchase decision. In order to verify these hypotheses, a detailed questionnaire was designed, and 1,650 valid questionnaires were distributed and successfully recovered through the online platform. Using SPSS software to analyze the data, the results show that the quality of live broadcast content and preferential activities have the most significant influence on consumers’ purchase decision, and the anchor’s personal charm and interaction between live broadcasts also show positive influence. Factor analysis further identifies five key factors: live broadcast content and quality, anchor influence, discount and promotion, social interaction and experience and shopping convenience. Based on the above findings, this paper constructs a multiple linear regression model to predict consumers’ purchase intention in live broadcast marketing. The goodness of fit test of the model shows that the R² value is 0.782, indicating that the model has good explanatory power for the data. Through residual analysis and Q-Q plot verification, the model meets the basic assumptions of linear regression and the prediction results are reliable. Finally, the study proposed comprehensive optimization suggestions for live broadcast marketing strategies, including improving the quality of live streaming content, cultivating the personal charm of hosts, enhancing the interactivity of live streaming rooms, and planning live streaming promotional activities reasonably. This article not only enriches the theoretical research on consumer behavior in the digital economy, but also provides practical guidance for enterprises to formulate effective live broadcast marketing strategies.
Prediction of mud cake formation for shield tunneling based on cutterhead opening parameters
Authors: Rong Xuening , Wang Nannan , Han Aimin , Ji Chaoling , Li Tong 
Published: December 2024

Abstract
During the shield tunneling, mud cake is one of the most common causes of cutterhead failure. Mud cake formation is a typical nonlinear process. Although the mud cake may block partial or all of the cutterhead opening, the relationship between mud cake and opening parameters has not been investigated. In this study, a prediction model of mud cake formation based on cutterhead opening is developed. The shapes of central and peripheral opening are quantified by central angle, central length, average peripheral width and standard deviation. The geological type is considered as another input parameter. A dataset of 151 real shield machines is normalized. The state of mud cake is labeled to train a model based on support vector machine (SVM). The proposed model is validated against the dataset and three other engineering cases in varied cities. Mutual relationship between mud cake and opening parameters is also investigated. It is shown that opening parameters play important roles in mud cake formation. Increasing central opening angle is an effective method to avoid mud caking. The risk of mud cake is rather small for the central angle larger than 80°. For higher length of central opening, the central angle can be even smaller. By checking the opening parameters, the risk of mud cake can be reduced before actual excavation.
Renal Stone Formation in Spaceflight
Authors: Hong Jun Hao , Cable Gordon 
Published: December 2024

Abstract
The microgravity environment of space increases bone resorption in astronauts, increasing urinary calcium excretion. Dehydration may also occur due to decreased fluid intake and increased fluid loss through insensible losses and space motion sickness. These factors increase the risk of renal stone formation. Renal stones can cause sudden incapacitating pain, requiring immediate treatment. Definitive treatment options are currently unavailable in space, necessitating a return to Earth. Thus, preventative strategies should be employed.
Dietary intake of calcium, oxalate and sodium should be controlled. Citrate intake can help decrease stone formation risk but may not be readily available in space. Potassium-magnesium citrate can be used as a supplement. Exercise and bisphosphonates help significantly mitigate bone mass loss due to microgravity but is inadequate to completely prevent stone formation risk. Thiazides have been trialed with good effect.
Various countermeasures have been investigated for general use and in spaceflight. They can potentially be used to mitigate stone formation risks in future missions. Risk of stone formation can be monitored using urinary biochemistry analyte normograms. These risk mitigation strategies can be employed in the general public to prevent recurrences and manage stone formation risks.
Efficacy of entomopathogenic nematodes present in Việt Nam against brown marmorated stink bug (Halyomorpha halys) under laboratory conditions
Authors: Dao Thi H. T. , Nguyen H. T. , Beattie G. A. C. , Holford P. , Trinh P. Q. , Bui P. T. , Tran H. T. T. , Nguyen V. D. , Le H. N. , Phung H. S. 
Published: December 2024

Summary
The brown marmorated stink bug (Halyomorpha halys), a native of Asia, has become an invasive pest in North America and Europe. Given the severity of H. halys and the need for better and environmentally-friendly control methods for this pest, we evaluated the virulence four entomopathogenic nematode species (Heterorhabditis indica, Oscheius myriophilus, Steinernema eapokense and Steinernema pakistanense) that occur naturally in soils in southern Việt Nam and compared them with that of a commercially available strain of S. carpocapsae. We report for the first time the pathogenicity of Oscheius myriophilus towards BMSB. The commercial strain of S. carpocapsae was most virulent against BMSB. However, the strain of S. pakistanense isolated from soil in southern Việt Nam has potential for the biological control of this pest. To achieve this potential, further work is needed including evaluation in the field and with the formulation of the nematode inoculum.
The Racial Mosaic: A Pre-History of Canadian Multiculturalism, by D. R. Meister. Reviewed by Adesoji Babalola.
Authors: Babalola Adesoji 
Published: December 2024

Review of The Racial Mosaic: A Pre-History of Canadian Multiculturalism by D. R. Meister. Reviewed by Adesoji Babalola.
A cobertura da triagem neonatal e as características sociodemográficas no Brasil, segundo dados da Pesquisa Nacional da Saúde – 2019
Authors: Xavier Juliana Cantele , Passos Camila Mendes dos , Penna Juliane Firmino Conte , Gualberto Géssica Teixeira , Gomes Maria Luiza Cacemiro , Abijaude Wesley , Teixeira Ísis Milani de Sousa , Quintão Gabrielly Vaillant , Prado Mara Rúbia Maciel Cardoso do , Prado Júnior Pedro Paulo do 
Published: December 2024

Objetivo: Descrever as coberturas dos rastreamentos da triagem neonatal no Brasil, a partir dos dados da Pesquisa Nacional da Saúde (PNS), e correlacionar com variáveis sociodemográficas. Métodos: Pesquisa quantitativa e descritiva, para a qual utilizou-se uma subamostra de dados coletados pela PNS de 2019. Foram analisadas frequências absolutas e relativas, além de seus intervalos de confiança. As coberturas dos testes e o recebimento de resultados foram estimados, considerando os estratos demográficos de idade, raça/cor, renda, região e área. Diferenças de prevalência foram avaliadas pelo teste Qui-quadrado de Pearson, com significância de 5%. Resultados: Observou-se uma maior proporção de crianças negras, de baixa renda, residentes no Norte e Nordeste e em área urbana. A menor cobertura encontrada foi de 61,9% para o teste do coraçãozinho. Houve variação na cobertura em tempo preconizado e acesso aos resultados. Identificaram-se iniquidades na cobertura, no acesso em tempo preconizado e no acesso aos resultados. Menores coberturas foram associadas a raça/cor, renda, região e área de moradia. A cobertura para triagem neonatal completa foi de 49,1%. Conclusão: O acesso ao teste do pezinho foi superior aos demais. O estudo também revelou disparidades sociodemográficas na triagem neonatal no Brasil, destacando a urgência de fortalecer as políticas intersetoriais.
ПОПУЛЯЦИОННО-ГЕНЕТИЧЕСКАЯ ХАРАКТЕРИСТИКА ЛОСЕЙ ПО ЛОКУСАМ МИКРОСАТЕЛЛИТОВ
Authors: Н.С. Марзанов , Д.А. Девришов , С.Н. Марзанова , О.Н. Ситникова , Л.К. Марзанова 
Published: December 2024

Цель исследования - разработка генодиагностики и характеристика популяционно-генетической структуры лосей по 6 локусам микросателлитов в условиях Сумароковской лосефермы Костромского государственного природного заказника. Процесс одомашнивания лосей в Костромской области проводится в течение длительного времени. Применяется полувольный выпас - лоси, в основном, кормятся в лесу, недалеко от фермы, а в загон самки приходят рожать. В настоящее время в лосеферме находится около 40 животных. В выборке из 24 животных изучен аллелофонд по 6 локусам микросателлитов. Нарушение генетического равновесия показано у пяти из шести микросателлитных локусов (BM6438, CSSM43, ETH225, BM1225, CSRM60). Наибольший процент гомозиготности из 6 исследованных локусов был показан в ETH225 (62,5%), CSRM60 (58,3%) и TGLA53 (41,7%). Наименьший показатель числа действующих аллелей Na установлен по локусу CSRM60 (1,83). Поскольку повышение уровня гомозиготности может приводить к ухудшению многих физиологических признаков, необходимо уточнить причины дефицита гетерозигот, которыми могут быть закрытость и немногочисленность популяции, смешение в выборке особей из генетически различающихся групп и другие факторы. Налаживание системы контроля разведения с использованием современных методов генодиагностики и популяционно-генетического анализа - это необходимый инструмент такого исследования.
The aim of the study was the development of genodiagnostics and the characteristics of the population-genetic structure of moose at six loci of microsatellites in the conditions of the Sumarokovskaya moose farm of the Kostroma State Nature Reserve. The process of moose domestication in the Kostroma region has been going on for a long time. It is used a semi-free grazing, moose mostly feed in the forest, not far from the farm, and in the enclosure the females come to give birth. Currently, there are about 40 animals in the moose farm. In a sample of 24 animals, an allelofund was examined for six loci of microsatellites. A violation of genetic equilibrium is shown in five of the six microsatellite loci (BM6438, CSSM43, ETH225, BM1225, CSRM60). The highest percentage of homozygosity from 6 investigated loci was shown in ETH225 (62.5%), CSRM60 (58.3%) and TGLA53 (41.7%). The lowest index of the number of acting alleles Na was established at the locus CSRM60 (1.83). Since an increase in the level of homozygosity can lead to the deterioration of many physiological signs, it is necessary to clarify the reasons for the heterozygote deficiency, which may be the closeness and scarcity of the population, the mixing in the sample of individuals from genetically different groups and other factors. Establishment of a control system for breeding using modern methods of genodiagnostics and population-genetic analysis is a necessary tool for such a study.
ИССЛЕДОВАНИЕ ЭФФЕКТОВ ИСПОЛЬЗОВАНИЯ РАСТВОРИМОГО ПОЛИКАТОНИТА В СОСТАВЕ КОРМОВЫХ ДОБАВОК: ПОЖИЗНЕННЫЙ ЭКСПЕРИМЕНТ НА КРЫСАХ
Authors: Грудина Н.В. , Быданова В.В. 
Published: December 2024

Наличие у высокомолекулярных водорастворимых полимеров комплексообразующих свойств позволяет широко применять их в различных областях промышленности и медицины, в частности для хемосорбции токсичных веществ, в том числе тяж`лых металлов и радионуклидов. Целью работы было: оценить безвредность кормовой добавки высокомолекулярного водорастворимого полимера (поликатионита ВПК-402) в условиях эксперимента на лабораторных животных (крысах) при ежедневном скармливания в течение 12 мес. Влияние тестируемого поликатионита оценивали по интегральным показателям здоровья, по биохимическим (активность ферментов АЛТ и АСТ, креатинин, общий билирубин) и гематологическим (уровень лейкоцитов, эритроцитов, лейкоформулы и др.) тестам, а также по результатам некропсии. Установлено, что полимер в дозах 1 и 2 мг/кг в пожизненном эксперименте не оказывает негативного влияния на основные гематологические и биохимические показатели крови. Результаты некропсии также не выявили патологии внутренних органов и тканей. У подопытных животных, получавших добавку, наблюдалась небольшое повышение в крови уровня эритроцитов и гемоглобина в сравнении с контролем (Р<0,05). Заключили, что что испытанный поликатионит ВПК-402 может быть рекомендован для использования в составе кормовых добавок для сельскохозяйственных животных.
ABSTRACT. The presence of complexing properties in high-molecular water-soluble polymers makes it possible to widely use them in various fields of industry and medicine, in particular, for the chemisorption of toxic substances, including heavy metals and radionuclides. The aim of the work was to evaluate the safety of of a high molecular weight water-soluble polymer (polycation exchanger VPK-402) as a component of feed additive under experimental conditions on rats with daily feeding for 12 months. The influence of the tested polycationite was assessed by integral indicators of health, by biochemical (activities of ALT and AST enzymes, creatinine, total bilirubin) and hematological (level of leukocytes, erythrocytes, leukoformula, etc.) tests, as well as by the results of necropsy. It was established that the polymer at doses of 1 and 2 mg/kg in a life-long experiment did not have a negative effect on the main hematological and biochemical blood parameters. The results of necropsy also did not reveal any pathology of internal organs and tissues. In experimental animals receiving the supplement, there was a slight increase in the content of hemoglobin in erythrocytes mass in comparison with the control (P<0.05). Concluded that the tested polycationite VPK-402 can be recommended for use as a component of feed additives for farm animals.