bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts
Authors: Cao Huan , Yang Liu , Hou Bin , Sun Dong , Lin Ling , Song Hong-Li , Shen Zhong-Yang 
Published: June 2020

Abstract
Background
Donation after circulatory death (DCD) liver grafts have a poor prognosis after transplantation. We investigated whether the outcome of DCD donor organs can be improved by heme oxygenase 1 (HO-1)-modified bone marrow-derived mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP), and explored its underlying mechanisms.

Methods
BMMSCs were isolated, cultured, and transduced with the HO-1 gene. An NMP system was established. DCD rat livers were obtained, preserved by different methods, and the recipients were divided into 5 groups: sham operation, static cold storage (SCS), NMP, BMMSCs combined with NMP, and HO-1/BMMSCs combined with NMP (HBP) groups. Rats were sacrificed at 1, 7, and 14 days after surgery; their blood and liver tissue samples were collected; and liver enzyme and cytokine levels, liver histology, high-mobility group box 1 (HMGB1) levels in monocytes and liver tissues, and expression of Toll-like receptor 4 (TLR4) pathway-related molecules were evaluated.

Results
After liver transplantation, the SCS group showed significantly increased transaminase levels, liver tissue damage, and shorter survival time. The HBP group showed lower transaminase levels, intact liver morphology, prolonged survival time, and decreased serum and liver proinflammatory cytokine levels. In the NMP and SCS groups, HMGB1 expression in the serum, monocytes, and liver tissues and TLR4 pathway-related molecule expression were significantly decreased.

Conclusions
HO-1/BMMSCs combined with NMP exerted protective effects on DCD donor liver and significantly improved recipient prognosis. The effect of HO-1/BMMSCs was greater than that of BMMSCs and was mediated via HMGB1 expression and TLR4 pathway inhibition.
Brain-derived nerve growth factor in the cochlea – a reproducibility study
Authors: Blakley Brian W. , Seaman Michael , Alenezi Abdulrahman 
Published: June 2020

Objective Brain-derived nerve growth factor (BDNF) plays an important role in cochlear development so it is plausible that it could restore hearing loss if delivered directly into the cochlea. We wished to confirm our previous report that a single intracochlear injection of brain-derived nerve growth factor (BDNF) was beneficial for hearing in guinea pigs. We wished to assess the reproducibility of our results and assess possible improved methods with a view to developing a clinical treatment for sensorineural hearing loss. Methods CDDP was used to create partial hearing loss in 25 guinea pigs. After 30 days the animals underwent ABR testing and unilateral BDNF injection through the round window in one ear and saline injection into the other ear. After allowing possible effects to stabilize, thirty days later, ABR threshold testing was repeated to assess change in threshold. Results Final ABR thresholds were 60–70 dB and were about 11 dB better in the ears treated with BDNF. Conclusion Our original finding that Intracochlear BDNF can improve hearing in guinea pigs was confirmed, but the improvement demonstrated by the methods in this paper is too small for clinical application.
Continuous monitoring of the 2015–2018 Nevado del Ruiz activity, Colombia, using satellite infrared images and local infrasound records
Authors: Castaño Lina Marcela , Ospina Carlos Alberto , Cadena Oscar Ernesto , Galvis-Arenas Beatriz , Londono John Makario , Laverde Carlos Andrés , Kaneko Takayuki , Ichihara Mie 
Published: June 2020

AbstractNevado del Ruiz Volcano (NRV) had a phreatomagmatic eruption in 1985. The eruption partially melted the volcano’s ice cap leading to floods and lahars flowing down to nearby towns, which killed at least 25,000 people. This event has raised particular importance of monitoring activity including small eruptions at ice-capped high-altitude volcanoes. However, the high altitude makes it difficult to maintain monitoring stations near the summit crater. Moreover, the visibility of the summit area is frequently prevented by clouds. In this paper, we report the results of a feasibility study for detecting thermal anomalies and small eruptions using satellite thermal remote sensing and ground-based infrasound technique. We newly included South and Central America to the observation areas of the near-real-time monitoring system of the active volcanoes, which uses infrared images from satellites. We also operated three infrasound stations in the distances of 4–6 km from the active crater. Each of the stations consisted of a pair of infrasound sensors, and a cross-correlation technique was applied. The thermal and infrasound data acquisition started in August 2015 and December 2016, respectively, and recorded the recent dome-forming activity of NRV. We proposed parameters representing the visibility of the thermal anomalies and infrasound signals. These parameters are useful for monitoring because the severe weather condition at NRV frequently prevents signal detections. We discussed the detected thermal anomalies and infrasound signals in comparison with their visibilities and the changes in the volcanic activity of NRV reported by the local observatory. The thermal anomaly and infrasound detections were consistent with the high eruptive activity occurring at the NRV from October 2015 to May 2017 and its subsequent decline. Within the active period, there were breaks in the detections of thermal anomaly and infrasound. The visibility analyses allowed us to interpret the breaks as a result of bad weather conditions and to distinguish them from the confirmed low-activity periods after May 2017.
CM6: a comprehensive geomagnetic field model derived from both CHAMP and Swarm satellite observations
Authors: Sabaka Terence J. , Tøffner-Clausen Lars , Olsen Nils , Finlay Christopher C. 
Published: June 2020

AbstractFrom the launch of the Ørsted satellite in 1999, through the CHAMP mission from 2000 to 2010, and now with the Swarm constellation mission starting in 2013, satellite magnetometry has provided excellent monitoring of the near-Earth magnetic field regime. The advanced Comprehensive Inversion scheme has been applied to data before Swarm and to the Swarm data itself, but now for the first time to all the satellite data in this new era, culminating in the CM6 model. The highlights of this model include not only a continuous core magnetic field description over the entire time period 1999 to 2019.5 in good agreement with the CHAOS model series, but the addition of two new oceanic tidal magnetic sources: the larger lunar elliptic semi-diurnal constituent $$N_2$$N2 and the lunar diurnal constituent $$O_1$$O1. CM6 is also the parent model of the NASA/GSFC candidates for the DGRF2015 and IGRF2020 in response to the IGRF-13 call. This paper provides a full report on the development of CM6.
Structural and bio-functional assessment of the postaxillary gland in Nidirana pleuraden (Amphibia: Anura: Ranidae)
Authors: Gong Yuzhou , Zeng Yiwei , Zheng Puyang , Liao Xun , Xie Feng 
Published: June 2020

Abstract
Background
Owing to their incomplete adaptation to the terrestrial environment, amphibians possess complex cutaneous glandular systems. The skin glands not only regulate water loss and respiratory gas and salt exchange, but are also involved in defense against predators and microorganisms, social communication, and reproduction. These glands are distributed throughout the integument, but can accumulate in specific regions, forming visible outgrowths known as macroglands. Some macroglands are sexually dimorphic and mediate intersexual communication and reproductive success. The postaxillary gland is a sexually dimorphic macrogland in Nidirana pleuraden. Its biological function and its morphological and histochemical characteristics are unclear. In the present study, we describe the structure and ultrastructure of the postaxillary gland, and explore its main function.

Results
The postaxillary gland has a thinner epidermis than the dorsal region of N. pleuraden. In addition to ordinary serous glands (OSG), type I and II mucous gland (I MG & II MG), a type of specialized mucous gland (SMG) is also found to constitute the postaxillary gland. The SMG is larger than other gland types, and consists of high columnar mucocytes with basal nuclei arranged radially toward a lumen. SMGs are positive to periodic acid-Schiff stain and stained blue in Masson’s trichrome stain. A discontinuous myoepithelial sheath lacking innervation encircles SMG mucocytes, and the outlets of such glands are X- or Y-shaped. Transmission electron microscopy reveals abundant secretory granules in SMG, which are biphasic, composed of an electron-opaque outer ring and a less electron-dense core. Lipid droplets, and organelles, such as rough endoplasmic reticulum and Golgi stacks, are located in the supranuclear cytoplasm of the mucocytes in SMG. Female N. pleuraden exhibits chemotaxis toward homogenate of the postaxillary gland, but male does not. On treatment with trypsin, this sexual attraction disappears.

Conclusions
The postaxillary gland of N. pleuraden is a male-specific macrogland that consists primarily of SMGs, together with OSGs, I MGs and II MGs. Other than their extremely large size, SMGs structurally and histochemically resemble many reported specialized gland types in amphibian sexually dimorphic skin glands. Secretions of the postaxillary gland are proteinaceous sexual pheromones, which are believed to attract females at male calling intermissions.
Adaptation and validation of the quality of life assessment of the Cambridge pulmonary hypertension outcome review (CAMPHOR) for Brazil
Authors: Corrêa Ricardo Amorim , Pereira Monica Corso , Bizzi Mariana Ferreira , de Oliveira Rafael W. R. , Rezende Camila Farnese , de Oliveira Bruna Cristina Marabita Tavares , Heaney Alice , McKenna Stephen P. , Ribeiro-Oliveira Antonio 
Published: June 2020

Abstract
Background
Pulmonary Hypertension (PH) impacts negatively on patients’ health-related quality of life (HRQoL). The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) was the first PH-specific and validated instrument for use in different languages worldwide. This report describes the adaptation and psychometric validation of the CAMPHOR into Brazilian Portuguese language.

Methods
The translation and validation process included a bilingual and lay panel translation; cognitive debriefing interviews; psychometric testing in two repeated times assessing internal consistency, reproducibility and validity of the questionnaire. The Nottingham Health Profile (NHP) questionnaire was used as a comparator to test for convergent validity.

Results
The translation captured the same concepts as the English questionnaire and produced a comprehensive instrument in a Brazilian-Portuguese version expressing common, natural language. The psychometric evaluation involved 102 patients (48.8 ± 14.5 years, 80,4% female]. Cronbach’s alpha coefficients were above 0.9 on all three CAMPHOR scales. There was excellent test-retest reliability (coefficients above 0.85 on all scales). CAMPHOR Symptoms scale and Activities scale correlated highly with Physical Mobility section and CAMPHOR QoL scale was strongly associated with the Emotional Reactions and Social Isolation sections of NHP. There was a significant association between gender and perceived general health (p < 0.05). There were significant differences in CAMPHOR scale scores between patients who differed according to their perceived disease severity and general health.

Conclusions
The present CAMPHOR version demonstrated good psychometric properties and provides a reliable instrument for assessing HRQL and QoL in Brazilian PH patients, addressing patients’ perspective of their illness in a comprehensive way.
Genetic Amelioration in lentil (Lens culinaris L.) using Different Doses of Ethyl Methane Sulphonate
Authors: El-Mouhamady Almoataz Bellah Ali , Gad Abdul Aziz M. , Abdel Karim Ghada S. A. 
Published: June 2020

Abstract
Background
Lentil is an important source of food not only locally but globally. The importance of this legume crop is highlighted in light of the transport of strategic food sources such as wheat, maize, and rice due to environmental challenges. So, the process of genetic improvement of this crop has become imperative.

Results
The final results confirmed that the three lentil cultivars Giza 9 (G1), Giza 29 (G2), and Giza 51 (G3) were exhibited unparalleled superiority for all growth, germination, and other traits under study when exposed to the three doses of ethyl methane sulfonate (EMS) compared to the control. Moreover, the three doses of this mutagen exceeded on the control experiment and this superiority were most severe especially at the third dose. The higher limit of positive percentages values of induced mutagenesis in M2 lentil generation (the second mutant generation) was observed in all studied traits especially at the third dose of EMS (0.3). This fact confirmed the success of the genetic improvement process in all lentil traits mentioned above.

Conclusion
The three lentil cultivars (Giza 9, Giza 29, and Giza 51) were recorded highly mean values of all studied in M2 generation for the three doses of EMS. The third dose of mutagen (0.3) was come in the first rank followed by the second dose (0.2) then the first dose in this regard.
Growth, yield, genetic parameters and random amplified polymorphic DNA (RAPD) of five rice varieties treated with sodium azide and sown under different saline conditions
Authors: Ikhajiagbe Beckley , Omoregie Ujomonigho Edomo 
Published: June 2020

Abstract
Background
Rice is probably one of the most indispensable grain diets for the greater part of the world. It can be grown successfully under a wide range of climatic conditions; however, yields can be significantly diminished under moderate saline levels. Therefore, the employment of plant breeding techniques in enhancing plant survival and performance capacities under saline conditions becomes imperative. Mutation perhaps is one of the ultimate sources from which heritable variations could be selected from and hence are a useful tool to create raw materials for genetic improvement of rice. The effects of sodium azide (NaN3), as a chemical mutagen, on the growth, yield, genetic parameters, and RAPD profile of five rice varieties, FARO-44, FARO-52, FARO-57, NERICA L-34, and NERICA L-47, sown in soils maintained at a conductivity range of 4000 to 6000 μs/cm using sodium chloride solutions were investigated. The planting materials were treated with 0% NaN3 at pH 7 (control) and a concentration range of 0 to 0.032% NaN3 at pH 3 for 6 h.

Results
Sodium azide treatment significantly reversed the negative effects associated with plant development under saline conditions. Consequently, NaN3 treatment significantly improved growth, yield, and genetic parameters of the rice varieties under high salinity compared with the controls. High heritability values were recorded for number of tillers per plant (78.06%), number of panicles per plant (78.74%), and 100-grain weight (98.15%) indicating the possibility of evolving higher yield variants through selection. Chlorophyll mutations observed were albino, viridis, and striata. The RAPD analyses with primers OPR 02 (5′–CAC AGC TGC C-3′), OPC 04 (5′-CCG CAT CTA C-3′), and OPC 05 (5′–GAT GAC CGC C-3′) revealed different DNA banding patterns between controls and NaN3-treated plants.

Conclusions
The study indicates that sodium azide is a potent mutagen, evident from information on genetic variability expressed by the DNA profiles of the rice varieties and their mutant counterparts as well as in the yield performances. The study thus indicated that the source of NaN3 induced variants among the treated progenies were genetic in nature and hence heritable. However, further screening on promising mutant plants from this research should be done through successive generations to identify stable traits and variant that can perform optimally under saline conditions.
The traditional and therapeutic use of banana and its plant based delicacies in ethnic Assamese cuisine and religious rituals from Northeast India
Authors: Sarma Upasana , Govila Viney Kumar , Yadav Akanksha 
Published: June 2020

AbstractAssam lies nestled in the far north-east corner of the Indian subcontinent. A country blessed with ample natural resources, the state of Assam also has a plethora of options in terms of choosing their core food sources. Banana or kol, as named in Assamese, has hundreds of varieties available in many parts of the world. They grow particularly well in tropical countries. It is found abundantly in the state of Assam and people have been making judicious use of the fruit and its plant parts in their cuisine since time immemorial. But nevertheless, a detailed review on its uses and importance and rising popularity in ethnic delicacies has not yet been documented well. This paper attempts to bring together the popular banana-based recipes of Assam state and its use in everyday religious ceremonies by the people of this community. It has age-old recipes used commonly in Assamese households and descriptive analysis of their microbial and biochemical diversity. It aims to bring to the fore the rising popularity of these ethnic dishes amongst modern population and is an attempt to revive these dishes and bring them into the mainstream Indian ethnic cuisine. As more and more people become aware of ethnic cuisine, it increases a global connectivity based on exchange of such information from lesser-known sources. The importance and significance of documenting these lesser-known recipes of Indian Assamese cuisine is an attempt to keep it relevant and take it to a broader audience who are appreciative of such oriental dishes. It is also high time a policy framework is worked upon by respective government of state and the centre for the true recognition and sustainability of such ethnic cuisine.
Using an airborne electromagnetic method to map saltwater intrusion in the northern Salinas Valley, California
Authors: Gottschalk Ian , Knight Rosemary , Asch Theodore , Abraham Jared , Cannia James 
Published: June 2020

Saltwater intrusion can pose a serious threat to groundwater quality in coastal regions. Estimating the extent of saltwater intrusion is vital for groundwater managers to plan appropriate mitigation strategies. The airborne electromagnetic (AEM) method is commonly used to evaluate groundwater resources, but it is challenging to apply in coastal environments because the low resistivity of saltwater-saturated aquifers attenuates the electromagnetic signal quickly and the relationship between electrical resistivity and pore water salinity is complex. However, if successful, the AEM method can supply information to address questions of critical importance in coastal regions. We investigated the extent of, and controls on, saltwater intrusion using the AEM method in the northern Salinas Valley, CA, USA. We collected 635 line-km of AEM data in the study area, the inversion results of which produced estimates of the electrical resistivity of the subsurface, reaching depths of between 50 and approximately 200 m below the ground surface. We have developed a relationship between the AEM electrical resistivity model and groundwater salinity, calibrated from borehole geophysical and water quality measurements, which allowed us to generate images revealing the distribution of saltwater and fresher groundwater in the study area. This fresher groundwater (defined as “a source of drinking water”) was successfully mapped out in the unconfined aquifer (the Dune Sand Aquifer) and the uppermost confined aquifer (the 180-Foot Aquifer) in the study area, illustrating a groundwater recharge process that helps mitigate saltwater intrusion in the 180-Foot Aquifer. Deep, low-resistivity bodies also were mapped, indicating regions where saltwater likely is migrating vertically from the 180-Foot Aquifer into the lower confined aquifer (the 400-Foot Aquifer). The findings from this case study demonstrate the value of acquiring AEM data for investigating the distribution of salinity in coastal aquifers impacted by saltwater intrusion.
A Pragmatic Approach to Inpatient Diabetes Management during the COVID-19 Pandemic
Authors: Korytkowski Mary , Antinori-Lent Kellie , Drincic Andjela , Hirsch Irl B , McDonnell Marie E , Rushakoff Robert , Muniyappa Ranganath 
Published: June 2020

Abstract
The pandemic of COVID-19 has presented new challenges to hospital personnel providing care for infected patients with diabetes who represent more than 20% of critically ill patients in intensive care units. Appropriate glycemic management contributes to a reduction in adverse clinical outcomes in acute illness but also requires intensive patient interactions for bedside glucose monitoring, intravenous and subcutaneous insulin administration, as well as rapid intervention for hypoglycemia events. These tasks are required at a time when minimizing patient interactions is recommended as a way of avoiding prolonged exposure to COVID-19 by health care personnel who often practice in settings with limited supplies of personal protective equipment. The purpose of this manuscript is to provide guidance for clinicians for reconciling recommended standards of care for infected hospitalized patients with diabetes while also addressing the daily realities of an overwhelmed health care system in many areas of the country. The use of modified protocols for insulin administration, bedside glucose monitoring, and medications such as glucocorticoids and hydroxychloroquine that may affect glycemic control are discussed. Continuous glucose monitoring systems have been proposed as an option for reducing time spent with patients, but there are important issues that need to be addressed if these are used in hospitalized patients. On-site and remote glucose management teams have potential to provide guidance in areas where there are shortages of personnel who have expertise in inpatient glycemic management.