bluuebunny/crossref_metadata_2025_split huggingface dataset:
The quality evaluation system establishment of mesenchymal stromal cells for cell-based therapy products
Authors: Xie Yuanyuan , Liu Wei , Liu Shuo , Wang Liudi , Mu Dan , Cui Yi , Cui Yanyan , Wang Bin 
Published: May 2020

AbstractBackgroundCell-based therapy products are supposed to be the most complex medicine products in the history of human medical care. In this study, we established a safety evaluation system for therapeutic stromal cells based on the existing regulations and current testing techniques to provide general quality requirements for human umbilical cord mesenchymal stromal cell (HUCMSC) therapy product.MethodsIn this system, we comprehensively evaluate the environmental monitoring program, quality control of critical raw materials and reagents, donor screening criteria, cell safety, quality, and biological effects, not only in line with the basic criteria of biological products, but also following the general requirements of drugs.ResultsThe qualified HUCMSCs were tested for various clinical researches in our hospital, and no severe adverse reaction was observed in 225 patients during a 1-year follow-up period.ConclusionIn this study, we establish a systemic quality control and potent assays to guarantee the safety and effectiveness of HUCMSCs based on a minimum set of standards in MSC-based product.
Performance bounds for diversity receptions over a new fading model with arbitrary branch correlation
Authors: Olutayo Adebola , Cheng Julian , Holzman Jonathan F. 
Published: May 2020

AbstractThe performance of a new (Beaulieu-Xie) fading model is analyzed using bounds. This recently proposed fading model can be used to describe both line-of-sight and non-line-of-sight components of a fading channel having different diversity orders. We consider the outage probability and error rate performance of maximal ratio combining, equal-gain combining, and selection combining over arbitrarily correlated Beaulieu-Xie fading channels. Closed-form expressions for upper and lower bounds to the outage probability and error rate are obtained, and it is shown that these bounds are asymptotically tight in the high signal-to-noise ratio regime. The analytical results are verified via Monte Carlo simulations. It is shown that the Beaulieu-Xie fading model can be more useful than the Ricean and Nakagami-m fading models in characterizing environments with both line-of-sight and multiple reflected specular components.
A class of Hilbert-type multiple integral inequalities with the kernel of generalized homogeneous function and its applications
Authors: Hong Yong , Liao Jianquan , Yang Bicheng , Chen Qiang 
Published: May 2020

AbstractLet $x=(x_{1},x_{2},\ldots,x_{n})$x=(x1,x2,…,xn), and let $K(u(x),v(y))$K(u(x),v(y)) satisfy $u(rx)=ru(x)$u(rx)=ru(x), $v(ry)=rv(y)$v(ry)=rv(y), $K(ru,v)=r^{\lambda\lambda_{1}}K(u, r^{-\frac{\lambda_{1}}{\lambda_{2}}}v)$K(ru,v)=rλλ1K(u,r−λ1λ2v), and $K(u,rv)=r^{\lambda\lambda_{2}}K(r^{-\frac{\lambda_{2}}{\lambda_{1}}}u, v)$K(u,rv)=rλλ2K(r−λ2λ1u,v). In this paper, we obtain a necessary and sufficient condition and the best constant factor for the Hilbert-type multiple integral inequality with kernel $K(u(x),v(y))$K(u(x),v(y)) and discuss its applications in the theory of operators.
Hopf bifurcation control for the main drive delay system of rolling mill
Authors: Wang Jinbin , Ma Lifeng , Wang Yong 
Published: May 2020

AbstractIn this work, the Hopf bifurcation of the main drive delay system of rolling mill is controlled and analyzed by designing a nonlinear controller. The time-delay is selected as a bifurcation parameter, and the following conclusions are obtained through analysis: (1) in the absence of state feedback control, the system will generate the Hopf bifurcation at the expense of its stability when the bifurcation parameter exceeds the threshold value; (2) in the state under feedback control, the occurrence of Hopf bifurcation is effectively delayed and the stable region of the system is also well extended. More importantly, we can change the properties of bifurcation periodic solutions by selecting the appropriate gain parameters. Some numerical simulations reveal that under the nonlinear feedback control, the vibration amplitude of the system can be effectively reduced.
Sharing values of q-difference-differential polynomials
Authors: Li Jian , Liu Kai 
Published: May 2020

AbstractThis paper is devoted to the uniqueness of q-difference-differential polynomials of different types. Using the idea of common zeros and common poles (Chin. Ann. Math., Ser. A 35:675–684, 2014), we improve the conditions of the former theorems and obtain some new results on the uniqueness of q-difference-differential polynomials of meromorphic functions.
Global existence of classical solutions for two-dimensional isentropic compressible Navier–Stokes equations with small initial mass
Authors: Li Wei , Shang Zhaoyang , Tang Fuquan 
Published: May 2020

AbstractIn this paper, we consider the initial-boundary value problem of two-dimensional isentropic compressible Navier–Stokes equations with vacuum on the square domain. Based on the time-weighted uniform estimates, we prove that the classical solution exists globally in time if the initial mass$\|\rho_{0}\|_{L^{1}}$∥ρ0∥L1of the fluid is small. Here, we do not require the initial energy or the upper bound of the initial density to be small.
Substance use prevention services in juvenile justice and behavioral health: results from a national survey
Authors: Funk Rodney , Knudsen Hannah K. , McReynolds Larkin S. , Bartkowski John P. , Elkington Katherine S. , Steele Ellen H. , Sales Jessica M. , Scott Christy K. 
Published: May 2020

Abstract
Background
This study examined the national availability of substance use prevention (SUP) within juvenile justice (JJ) and their primary behavioral health (BH) providers, and the relationships between the availability of SUP and agency-level measures of organizational structure, staffing, and youth characteristics. A three-stage national probability sampling process was used to select participants for a national survey that included, among other facets of community supervision (CS) and BH practices, questions on agency characteristics, youth characteristics, whether the agency/provider directly provided SUP services, and whether the agency/provider directly provided substance use and/or mental health treatment. This paper focuses on SUP services along with agency/provider and youth characteristics related to providing SUP.

Results
The response rate for both CS agencies (n = 195) and BH providers (n = 271) was 96%. Complex samples logistic regression initially examined univariate associations of each variable and identified candidates for a final multivariate model. Overall, only one-third of CS and BH providers reported offering SUP services, with BH providers being significantly more likely than CS agencies to provide SUP services. In addition, likelihood of SUP was significantly lower among agencies where the substance use distribution of the caseload was below the median. Controlling for master’s level staff and the substance use distribution, CS agencies were about 67% less likely to offer SUP when compared to BH providers.

Conclusions
Given the high rates of substance use among justice-involved youth and that substance use is an established risk for several negative behaviors, outcomes, and health conditions, these findings suggest that evidence-based prevention services should likely be expanded in justice settings, and perhaps included as part of CS programs, even when youth do not initially present with SU service needs.
Effects of boron toxicity on growth, oxidative damage, antioxidant enzymes and essential oil fingerprinting in Mentha arvensis and Cymbopogon flexuosus
Authors: Choudhary Sadaf , Zehra Andleeb , Naeem M. , Khan M. Masroor A. , Aftab Tariq 
Published: May 2020

AbstractBackgroundBoron (B) is an essential micronutrient and necessary to plants for their proper growth. The concentration of B in soil and plant is greatly critical for the growth and productivity. Even at the low amount available in soils, B can be extremely toxic to plants especially in semi-arid and arid environments. In the present study, the effects of high B concentrations (2.5, 5, 10, 20 and 30 mg/kg) were elucidated on two important essential oil-bearing plants;Mentha arvensisandCymbopogon flexuosuswhich are aromatic and antimicrobial herbs having well-known medicinal values.ResultsApplication of different concentrations of B showed growth inhibitory effects on plant as evident by shoot and root lengths, fresh and dry weights of shoot in the studied plants. Treatments of B also reduced the total chlorophyll and carotenoid content, chlorophyll fluorescence and reduced the activities of carbonic anhydrase and nitrate reductase enzymes. Moreover, B stress considerably increased the proline content and lipid peroxide content as compared to control. The activities of antioxidant enzymes like catalase, peroxidase and superoxide dismutase were also significantly increased under B stress. The content of essential oil ofM. arvensisandC. flexuosusincreased at 2.5 mg/kg of B and decreased with further increase in concentrations of B.ConclusionThe findings of present work suggest that increasing concentrations of B inhibited growth and photosynthetic pigments, increased oxidative damage and activities of antioxidant enzymes; however, a mild stress of B increased essential oil production inM. arvensisandC. flexuosusplants.
Evaluation of a novel portable three-dimensional scapular kinematics assessment system with inter and intraobserver reproducibility and normative data for healthy adults
Authors: Ruiz Ibán Miguel Angel , Paniagua Gonzalez Andrea , Muraccini Marco , Asenjo Gismero Cristina , Varini Alessandro , Berardi Antonella , Mantovani Matteo 
Published: May 2020

AbstractPurposeTo evaluate the intra and interobserver reproducibility of a new system that assesses the three-dimensional humero-scapulo-thoracic kinematics using wearable technology in an outpatient setting. To obtain normative data with the system for scapular angular motions in three planes.MethodsThe SHoW Motion 3D kinematic tracking system is a motion analysis system that uses wireless wearable non-invasive inertial-magnetic sensors to assess the three-dimensional kinematics of the shoulder girdle. The sensors are placed over the skin in the sternum, scapular spine and arm to precisely define angular motions of the humerus and the scapula with three Degrees of Freedom (DOF) for each segment.The system was used to measure the scapular angular motions in three planes (upward/downward rotation, internal/external rotation and anterior/posterior tilt) during two shoulder full-range movements (flexion/extension and abduction/abduction) in both shoulders of 25 healthy volunteers (13 males and 12 females, mean age: 37 [standard deviation 11.1] years). In a first measuring session one examiner made two evaluations alternating with another examiner that made a third evaluation. In a second session, one week apart, the first examiner made a fourth evaluation.A mean curve was computed from the normalized data for each measurement to obtain normative data for scapular angular kinematics. Intra and inter-observer reproducibility was evaluated using Root Mean Square Error Estimation (RMSE) and Coefficients for Multiple Correlations (CMC).ResultsBoth shoulders of the 25 volunteers were evaluated four times. The two hundred resulting kinematic analyses were pooled to get normative values for relations between humeral elevation angles and the three angular movements of the scapula.The system showed at least very good (CMC > 0.90) intra and inter-observer reproducibility for scapular tilt and upward-downward rotations both in flexion and abduction. For scapular internal-external rotation the results were acceptable (CMC > 0.75) but not as good, especially for the abduction movement. RMSE calculations showed consistently good reproducibility with RSME< 4° for all three angles evaluated in flexion and abduction.ConclusionThe SHoW Motion 3D kinematic tracking system is a quick, reproducible and easy to use system for the assessment of scapular angular kinematics in healthy adults. The data obtained is similar to that obtained with other validated methods.Level of evidenceLevel II.Clinical relevanceThe presented system is portable, easy to use and fast. It also has good intra and inter-observer reproducibility, making it a good tool to assess objectively scapular dyskinesis in the clinical setting. The normative data obtained is consistent with previous information available.
COVID-19 - ESSKA guidelines and recommendations for resuming elective surgery
Authors: Mouton Caroline , Hirschmann Michael T. , Ollivier Matthieu , Seil Romain , Menetrey Jacques 
Published: May 2020

AbstractThe roadmap to elective surgery resumption after this COVID-19 pandemic should be progressive and cautious. The aim of this paper was to give recommendations and guidelines for resuming elective orthopedic surgery in the safest environment possible. Elective surgery should be performed in COVID-free facilities and hospital stay should be as short as possible. For matters of safety, patients considered first for surgery should be carefully selected according to COVID infection status/exposure, age, ASA physical status classification system / risk factors, socio-professional situation and surgical indication. A strategy for resuming elective surgery in four phases is proposed. Preoperative testing for COVID-19 infection is highly recommended. In any cases, COVID symptoms including fever and increased temperature should be constantly monitored until the day of surgery. Elective surgery should be postponed at the slightest suspicion of a COVID-19 infection. In case of surgery, adapted personal protective equipment in terms of gowns, gloves, masks and eye protection is highly recommended and described.
In vitro characterization of PrismaLung+: a novel ECCO2R device
Authors: Hospach Ingeborg , Goldstein Jacques , Harenski Kai , Laffey John G. , Pouchoulin Dominique , Raible Manuela , Votteler Stefanie , Storr Markus 
Published: May 2020

Abstract
Background
Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO2 removal (ECCO2R) technologies may facilitate more protective lung ventilation in acute respiratory distress syndrome, and enable earlier weaning and/or avoid invasive mechanical ventilation entirely in chronic obstructive pulmonary disease exacerbations. We evaluated the in vitro CO2 removal capacity of the novel PrismaLung+ ECCO2R device compared with two existing gas exchangers.

Methods
The in vitro CO2 removal capacity of the PrismaLung+ (surface area 0.8 m2, Baxter) was compared with the PrismaLung (surface area 0.35 m2, Baxter) and A.L.ONE (surface area 1.35 m2, Eurosets) devices, using a closed-loop bovine blood–perfused extracorporeal circuit. The efficacy of each device was measured at varying pCO2 inlet (pinCO2) levels (45, 60, and 80 mmHg) and blood flow rates (QB) of 200–450 mL/min; the PrismaLung+ and A.L.ONE devices were also tested at a QB of 600 mL/min. The amount of CO2 removed by each device was assessed by measurement of the CO2 infused to maintain circuit equilibrium (CO2 infusion method) and compared with measured CO2 concentrations in the inlet and outlet of the CO2 removal device (blood gas analysis method).

Results
The PrismaLung+ device performed similarly to the A.L.ONE device, with both devices demonstrating CO2 removal rates ~ 50% greater than the PrismaLung device. CO2 removal rates were 73 ± 4.0, 44 ± 2.5, and 72 ± 1.9 mL/min, for PrismaLung+, PrismaLung, and A.L.ONE, respectively, at QB 300 mL/min and pinCO2 45 mmHg. A Bland–Altman plot demonstrated that the CO2 infusion method was comparable to the blood gas analysis method for calculating CO2 removal. The resistance to blood flow across the test device, as measured by pressure drop, varied as a function of blood flow rate, and was greatest for PrismaLung and lowest for the A.L.ONE device.

Conclusions
The newly developed PrismaLung+ performed more effectively than PrismaLung, with performance of CO2 removal comparable to A.L.ONE at the flow rates tested, despite the smaller membrane surface area of PrismaLung+ versus A.L.ONE. Clinical testing of PrismaLung+ is warranted to further characterize its performance.
Cultural responsiveness in the Incredible Years parenting programme for refugees: a case study
Authors: Danbolt Anne Marit Vesteraas 
Published: May 2020

AbstractThe Incredible Years is a parenting programme that has been implemented in several countries, and in later years also used in groups consisting of newly arrived immigrant families. The aim of this paper is to explore how refugee parents perceive the cultural responsiveness in the Incredible Years programme offered to a group of newly arrived refugee parents in a municipality in Norway. A key feature of the implementation was the role of the interpreters, as they were considered co-workers with the group leaders and held key roles in the Incredible Years programme. Whilst the dialogic nature of the Incredible Years programme and the open-mindedness of the group leaders promoted a reasonable responsiveness in the implementation, the empowered role of the interpreters was the most crucial point in securing a responsive cross-cultural dialogue. In a situation characterised by uncertainty, the social capital of the family seemed to gain increased value, and the participants were hesitant to discuss any problems with their children. The findings are useful for the provision of the Incredible Years programme to immigrant or refugee families who will need interpreters to take part in the courses.
A comparison of biologicals in the treatment of adults with severe asthma – real-life experiences
Authors: Kotisalmi Emma , Hakulinen Auli , Mäkelä Mika , Toppila-Salmi Sanna , Kauppi Paula 
Published: May 2020

Abstract
Background
Anti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biological therapy on severe asthma and to compare different therapies.

Methods
We collected and analysed results of anti-IL5/IL5R and anti-IgE therapies for asthma from January 2009 until October 2019 in specialized care. We compared number of exacerbations, asthma symptoms and use of per oral corticosteroids and antimicrobics because of asthma before and during biological therapy, and in a separate analysis need for per oral corticosteroids, antimicrobics or surgery due to upper respiratory tract diseases in asthmatics receiving biologicals. The analyses were done using the Chi square test, T-test or Mann-Whitney U -test, the Kruskall-Wallis test or the Wilcoxon test.

Results
Of 64 patients, 40 used continuous per oral corticosteroid therapy prior to biological therapy. The mean daily dose of per oral corticosteroid was reduced in those with anti-IL5/IL5R therapy (− 3.0 mg, p = 0.02). The number of annual per oral corticosteroid courses decreased in both the anti-IL5/IL5R (− 2.8 courses, p < 0.05) and anti-IgE groups (− 1.3 courses, p < 0.05). The number of annual antibiotic courses (− 0.7 courses, p = 0.04) and total number of exacerbation events (− 4.4 events/year, p < 0.05) were reduced in the anti-IL5/IL5R group. In the 55 asthma patients analysed for upper respiratory tract findings, the results suggested a reduction in need for chronic rhinosinusitis surgery during biological therapy.

Conclusions
Results with biological therapies in this real-life clinical setting are comparable to those reported in clinical trials. Biological therapy reduces exacerbations and per oral corticosteroid use.

Trial registration
NCT04158050, retrospectively registered 6.11.2019.
Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy
Authors: Sugimoto Ai , Takigiku Kiyohiro , Shiraishi Shuichi , Takahashi Masashi , Tsuchida Masanori 
Published: May 2020

Abstract
Background
In a Fontan candidate, univentricular pacing may cause delay in interventricular conduction, which induces asynchronous contraction. Cardiac resynchronization therapy is expected to be an effective mode of therapy in such a case.

Case presentation
A 7-month-old girl, diagnosed with dextrocardia, congenitally corrected transposition of the great artery [situs solitus, L-loop, and L-transposition], ventricular septal defect, infundibular and pulmonary valvular stenosis, and straddling of the tricuspid valve, was considered as a candidate for the Fontan procedure. She had undergone Blalock-Taussig shunt, and epicardial univentricular pacemaker implantation for persistent complete atrioventricular block. She underwent a bidirectional cavopulmonary shunt concomitant with ventricular lead translocation from the morphological left ventricle to the morphological right ventricle. After discharge, ventricular dyssynchrony was noted and cardiac failure persisted. She was converted to cardiac resynchronization therapy (CRT) at 13 months of age. Two-dimensional speckle tracking imaging was used by cardiologists to determine the most suitable pacing site. CRT rapidly corrected the heart failure; thus, she underwent the Fontan procedure after 1.5 years. Five years have passed since the cardiac resynchronization therapy; her interventricular synchrony is maintained well and the level of brain natriuretic peptide remains within normal range.

Conclusion
We describe the successful conversion from single ventricular pacing to CRT, in a case of congenitally corrected transposition of the great artery indicated for the Fontan procedure. The long-term prognosis of cardiac resynchronization therapy is undetermined in the pediatric population; therefore, further follow-up is required.