bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Chorioamnionitis With Failed Conversion of Epidural Labor Analgesia to Cesarean Delivery Anesthesia: a Retrospective Cohort Study
Authors: Katakura Yumi , Nagamine Yusuke , Goto Takahisa , Sumikura Hiroyuki 
Published: August 2020

Abstract
Background: This study examined the association between clinically diagnosed chorioamnionitis and failed conversion of epidural labor analgesia to cesarean delivery anesthesia.Methods: This retrospective cohort study, conducted in a single-center university hospital, enrolled term parturients undergoing emergency cesarean section after induction of epidural labor analgesia between September 2015 and May 2019. For the purpose of the study, all cases were re-examined to ensure that they fulfilled the criteria of chorioamnionitis, regardless of the actual indication for cesarean section proposed by obstetricians at the time of application. The primary outcome was failure of conversion of epidural labor analgesia to cesarean delivery anesthesia. Multivariable logistic regression analysis was performed to investigate the association between chorioamnionitis and failure of anesthesia for cesarean section.Results: Among the 180 parturients, it was found that 58 parturients (43.9%) fulfilled the criteria of chorioamnionitis. Failure of epidural conversion in the chorioamnionitis (+) group was significantly higher than that in the chorioamnionitis (-) group (46.6 % [27/58] vs. 18.9% [14/74], crude odds ratio = 3.7, 95% confidence interval 1.7-8.3). After adjustment for potential confounders (age, body mass index, multiparity, and duration for epidural labor analgesia), chorioamnionitis was found to be associated with failure of anesthesia for cesarean sections (adjusted odds ratio = 3.6, 95% confidence interval 1.6-8.4). Conclusions: Chorioamnionitis is associated with the failed conversion of epidural labor analgesia to cesarean delivery anesthesia.
Blood Lead alters the anemia status of malaria infected children in Katanga Kampala Uganda.
Authors: Mukisa Ambrose K , Kasozi Denis M , Aguttu Claire , Vuzi Peter C. , Kyambadde Joseph 
Published: August 2020

Abstract
Background Uganda, like other malaria endemic countries, childhood anemia due to malaria infection, malnutrition and social disadvantages remains a health challenge. Other contributing factors towards the pathogenesis of this disease like blood lead have not been fully explored. Persistent lead exposure accounts for one’s blood lead levels and other many health outcomes. Recent studies report elevated environmental lead levels in urban Uganda with anthropogenic activities including leaded paints, leaded fuels spillages, lead-contaminated air, water and soils listed as major sources. Blood lead (BL) alters iron bioavailability by competitively blocking iron absorption hence anemia. BL inhibits key enzymes ferrochelatase and aminolevulinic acid dehydratase (ALAD) involved in hemoglobin (Hb) biosynthesis resulting into elevated free erythrocyte protoporphyrin (FEP). Children in this area are generally anemic due chronic exposure to malaria parasites that thrive on their red blood cells for survival. Concomitant exposure to both malaria infection and lead pollution, exerbates the anemia status of these children. This study therefore aimed at expounding the anemia status of these Ugandan children simultaneously living exposed to both malaria infection and environmental lead pollution. Methods Briefly venous blood samples from 198 children were microscopically assayed for malaria parasite density, hemoglobin (Hb) concentrations by the cyanmethemoglobin method, BL levels by the standard atomic absorption spectrophotometric method and FEP levels by the standard fluorimetric method. Results A total of 151/198 (76.3%) children were analyzed with moderate anemia (Hb <10>5 g/dL) while 8/198 (4%) had severe anemia (<5 g/dL). They had means of BL levels (9.3 µg/dL), Hb (7.5 g/dL), FEP/Hb (8.3 µg/g) and parasite density (PD) (3.21×103 parasites / µL). There was weak negative correlation between PD and Hb (r = -0.231, R2= 0.15 P-value < 0.001), as compared to that between FEP/Hb and Hb (r = -0.6, R2=0.572 P-value=0.001). Conclusion Basing on this study’s findings, we conclude that BL is a significant contributor to anemia pathogenesis and therefore its co-existence with plasmodium malaria infection in the host exerbates the anemia status.Trial registration Not applicable
SARS-CoV-2 analysis on environmental surfaces collected in an intensive care unit. Keeping Ernest Shackleton´s spirit.
Authors: Escudero Dolores , Boga Jose Antonio , Fernández Javier , Forcelledo Lorena , Balboa Salvador , Albillos Rodrigo , Astola Iván , García-Prieto Emilio , Álvarez-Argüelles Marta Elena , Martín Gabriel , Jiménez Josu , Vázquez Fernando 
Published: August 2020

Abstract
Background Intensive care unit workers are at high risk of acquiring COVID-19 infection, specially when performing invasive techniques and certain procedures that generate aerosols (<5 µm). Therefore, one of the objectives of the health systems should be to implement safety practices to minimize the risk of contagion among these health professionals. Monitoring environmental contamination of SARS-CoV-2 may help to determine the potential of the environment as a transmission medium in an area highly exposed to SARS-CoV-2, such as an intensive care unit. The objective of the study was to analyze the environmental contamination by SARS-CoV-2 on surfaces collected in an intensive care unit, which is dedicated exclusively to the care of patients with COVID-19 and equipped with negative pressure of -10 pascals and an air change rate of 20 cycles per hour. Results A total of 102 samples (72 collected with pre-moistened swabs used for collection of nasopharyngeal exudates and 30 with moistened wipes used in the environmental microbiological control of the food industry) were obtained from ventilators, monitors, perfusion pumps, bed rails, lab benches, containers of personal protective equipment, computer keyboards and mice, telephones, workers' shoes, floor and other areas of close contact with COVID-19 patients and healthcare professionals who cared for them. The analysis by quantitative RT-PCR showed no detection of SARS-CoV-2 genome in environmental samples collected by any of the two methods described.Conclusions Presence of SARS-CoV-2 on the ICU surfaces could not be determined supporting that personal protection, decontamination procedures and negative pressure settings are effective in preventing environmental contamination and protecting the staff and patients inside intensive care units.
Localized spin-orbit polaron in magnetic Weyl semimetal Co3Sn2S2
Authors: Xing Yuqing , Shen Jianlei , Chen Hui , Huang Li , Gao Yuxiang , Zheng Qi , Zhang Yu-Yang , Li Geng , Hu Bin , Qian Guojian , Cao Lu , Zhang Xianli , Fan Peng , Ma Ruisong , Wang Qi , Yin Qiangwei , Lei Hechang , Ji Wei , Du Shixuan , Yang Haitao , Shen Chengmin , Lin X. , Liu Enke , Shen Baogen , Wang Ziqiang , Gao Hong-Jun 
Published: August 2020

Abstract
The kagome lattice Co3Sn2S2 exhibits the quintessential topological phenomena of a magnetic Weyl semimetal such as the chiral anomaly and Fermi-arc surface states. Probing its magnetic properties is crucial for understanding this correlated topological state. Here, using spin-polarized scanning tunneling microscopy/spectroscopy (STM/S) and non-contact atomic force microscopy (nc-AFM) combined with first-principle calculations, we report the discovery of localized spin-orbit polarons (SOPs) with three-fold rotation symmetry nucleated around single S-vacancies in Co3Sn2S2. The SOPs carry a magnetic moment and a large diamagnetic orbital magnetization of a possible topological origin associated relating to the diamagnetic circulating current around the S-vacancy. Appreciable magneto-elastic coupling of the SOP is detected by nc-AFM and STM. Our findings suggest that the SOPs can enhance magnetism and stability of the magnetic Weyl nodes for more robust time-reversal-symmetry-breaking topological phenomena. Controlled engineering of the SOPs may pave the way toward practical applications in functional quantum devices.
Comparison of prognostic impact of anatomic location of the pancreas on postoperative pancreatic fistula in laparoscopic and open gastrectomy
Authors: Kinoshita Jun , Yamaguchi Takahisa , Saito Hiroto , Moriyama Hideki , Shimada Mari , Terai Shiro , Okamoto Koichi , Nakanuma Shinichi , Makino Isamu , Nakamura Keishi , Tajima Hidehiro , Ninomiya Itasu , Fushida Sachio 
Published: August 2020

Abstract
Background
Postoperative pancreatic fistula (POPF) is a serious complication after gastric cancer surgery. The current study aimed to investigate the significance of the anatomic location of the pancreas as a predictor for POPF in both laparoscopic gastrectomy (LG) and open gastrectomy (OG).
Methods
In total, 233 patients with gastric cancer were assessed retrospectively. We measured the maximum vertical (P-L height; PLH) and horizontal length (P-L depth; PLD) between the upper border of pancreas and the root of left gastric artery on a preoperative CT in the sagittal direction. The maximum length of the vertical line between the surface of the pancreas and the aorta (P-A length), previously reported as prognostic factor of POPF, was also measured. We investigated the correlations between these parameters and the incidence of POPF in LG and OG groups.
Results
Among the patients in this study, 118 underwent OG and 115 underwent LG. In LG, the median PLH and P-A length in patients with POPF were significantly longer compared with those without POPF (p = 0.026, 0.034, respectively), but not in OG. There was no significant difference in the median PLD between the patients with or without POPF in both LG and OG. The multivariate analysis demonstrated that PLH (odds ratio [OR] 4.19, 95% confidence interval [CI] 1.57–11.3, P = 0.004) and P-A length (OR 4.06, 95%CI 1.05–15.7, P = 0.042] were independent factors for predicting POPF in LG. However, intraoperative blood loss (OR 2.55, 95%CI 1.05–6.18, P = 0.038) was extracted as an independent factor in OG. The median amylase level in the drained fluid (D-Amy) were significantly higher in patients with high PLH(≥ 12.4 mm) or high P-A length (≥ 45 mm) compared with those with low PLH or low P-A length in LG. However, there were no differences in the D-Amy levels by PLH or P-A length in OG patients.
Conclusions
The anatomic location of the pancreas is a specific and independent predictor of POPF in LG but not in OG. PLH is a simple parameter that can evaluate the anatomic position of the pancreas, and it may be useful for preventing POPF after LG.
Resilience and sense of coherence in first year medical students - a cross-sectional study
Authors: Luibl Lena , Traversari Julia , Paulsen Friedrich , Scholz Michael , Burger Pascal 
Published: August 2020

Abstract
Background: A broad range of high-quality studies show that medical students often have a significantly deteriorated mental health status. Although starting medical school with values comparable to the population average, only a few semesters later, medical undergraduates show increased rates of psychological risk states and some manifest mental illnesses, such as burnout and depression. In our survey we intentionally assessed mental health parameters from a salutogenetic, i.e. resource-oriented point of view. Methods: We examined first-year medical students in a cross-sectional study and assessed sense of coherence (SOC) and resilience as parameters from the salutogenesis model by Antonovsky in a structured way using validated, self-administered questionnaires. In total, we examined 236 students of human medicine, dentistry and molecular medicine at the Friedrich-Alexander-University Erlangen-Nürnberg (FAU).Results: Our analyses showed significantly higher values of resilience among male students compared to female students. In contrast, even though a significant correlation between resilience and SOC was observed, only a non-significantly lower value of SOC was found in female students. Compared to the population average our medical students in their first year of study showed significantly lower values for resilience and SOC. Conclusion: Resilience and SOC are known to correlate with psychological stress (burnout parameters) and depression. In order to keep protective factors like SOC and resilience in medical students at a good and healthy level we see the necessity to address that problem proactively and also from the teaching side. Integrating training focused on the preservation of the students´ own mental health into the medical curriculum from the beginning of university courses, and throughout the whole medical study course, is essential and should be an obligatory training goal. Based on our study results, we also deem it necessary to think about ways to adapt the measures for the gender-specific needs of our students, e.g. dependent on their biological gender.
Voltage hysteresis during lithiation/delithiation of graphite associated with meta-stable carbon stackings
Authors: Mercer Michael , Peng Chao , Soares Cindy , Hoster Harry , Kramer Denis 
Published: August 2020

Abstract
Cell voltage is a fundamental quantity used to monitor and control Li-ion batteries. The open circuit voltage (OCV) is of particular interest as it is believed to be a thermodynamic quantity, free of kinetic effects and history and, therefore, "simple" to interpret. Here we show that the OCV characteristics of graphite show hysteresis between charge and discharge that does not solely originate from Li dynamics and that the OCV is in fact history dependent. Combining First Principles calculations with temperature-controlled electrochemical measurements, we identify a residual hysteresis that persists even at elevated temperatures of greater than 50°C due to differences in the phase succession between charge and discharge. Experimental entropy profiling, as well as energies and volume changes determined from First Principles calculations, suggest that the residual hysteresis is associated with different host lattice stackings of carbon and is related to Li disorder across planes in stage II configurations.
Temporomandibular Joint Ankylosis Among Patients at Saint Paul’s Hospital Millennium Medical College, Ethiopia: a 9 Year Retrospective Study
Authors: Mekonnen Dereje , Gizaw Andamlak , Kebede Bruktawit 
Published: August 2020

Abstract
Background: Temporomandibular joint ankylosis (TMJA) is a gradually developing pathological condition manifested by a limited mouth opening. It can result in an extremely disabling situation that may affect mastication, swallowing, speech, oral hygiene, and facial cosmetic appearance. The present study was aimed to determine the pattern of TMJA at St. Paul’s Hospital millennium medical college (SPHMMC), Addis Ababa, Ethiopia.Methods: A retrospective descriptive study design was conducted at SPHMMC. All medical records of patients with the diagnosis of TMJA that visited the Maxillofacial Surgery unit from September 2010 through August 2019 were reviewed. Clinical data including age, sex, place of residency, duration of the case, etiology, clinical presentations, imaging results, the type of operation and complications after surgery were collected, and analyzed by using SPSS version 20.0 windows software computer program. Results: A total of 130 patients’ medical records were reviewed. Out of this, 95 were included in the study. 42(44.2%) of the TMJA case were males, while the remaining 53(55.8%) were females with a female to male ratio of 1.26:1. The most affected age group was 20 to 39 years 36(37.9%), followed by the age group of 30 to 39 years 33(34.7%). Trauma was identified as the most common cause of TMJA. Notably, bilateral ankylosis was more common than unilateral, and mandibular deformity (micrognathia) was the most common deformity observed. The majority 52(54.7%) of TMJA patients were treated with Gap arthroplasty.Conclusions: Trauma was identified as the main cause of TMJA. The majority of TMJA cases were surgically treated with Gap arthroplasty with almost no postoperative complications. Thus early detection and intervention to release the ankylosed joint is needed to improve patient’s quality of life.
The Immediate Effect of COVID-19 Pandemic on Children and Adolescents with Obsessive Compulsive Disorder
Authors: Nissen Judith Becker , Højgaard David , Thomsen Per Hove 
Published: August 2020

Abstract
BackgroundObsessive compulsive disorder (OCD) is a distressing psychiatric disorder. Traumas may trigger or aggravate OCD symptoms. COVID-19 pandemic has coursed a global crisis and has been associated with onset of psychiatric disorders in adults. Little is known about children/adolescents with OCD. The present study aimed to examine how children/adolescents with OCD react towards COVID-19 crisis. MethodsA questionnaire was distributed to two separate groups of children/adolescents. One group was a clinical group newly diagnosed at a specialized OCD clinic. All the children/adolescents had a current close contact to a therapist or doctor. The other group was a survey group identified through the Danish OCD Association. Most of these children/adolescents were diagnosed years ago, and their primary treatment was completed. For the clinical group, data from patient files was available. ResultsIn both groups, but most pronounced in the survey group, participants experienced a worsening of their OCD, anxiety, and depressive symptoms. The aggravation of OCD correlated with the worsening of anxiety, depressive symptoms, and the extent of avoidance behavior. For both groups, OCD aggressive symptoms predicted a significant worsening. Poor baseline insight showed a trend to predict a symptom worsening. The worsening was most pronounced in children with early age of onset and a family history of attention deficit hyperactivity disorder.ConclusionsTo our knowledge, this is the first study examining the effect of COVID-19 in children/adolescents with OCD. The effect was examined in two separate populations strengthening the findings. The study points towards an influence of the OCD phenotype differentiating the early-onset group from the adult group, baseline insight suggesting a continued vulnerability, and a family history of psychiatric disorders. Trial registrationThe study is approved by the Danish Data Protection Agency (1-16-02-147-20) registered 1st of April 2020. Oral and written information was given to parents and patients and written consent from patients over 15 years and parents were received.
Expression profile analysis of Differentially Expressed Genes in Human Coronary Artery Endothelial Cells Induced by Serum from Kawasaki Disease: A preliminary study
Authors: Fan Xue , Li Meng , Xiao Min , Liu Cong , Xu Mingguo 
Published: August 2020

Abstract
Background: Kawasaki disease (KD) leads to coronary artery damage and the etiology of KD is unknown. The present study was designed to explore the differentially expressed genes (DEGs) in KD serum-induced human coronary artery endothelial cells (HCAECs) by RNA-sequence (RNA-seq). Methods: HCAECs were stimulated with serum (15% (v/v)), which were collected from 20 healthy children and 20 KD patients, for 24 hours. DEGs were then detected and analyzed by RNA-seq and bioinformatics analysis. Results: The expression of SMAD1, SMAD6, CD34, CXCL1, PITX2, and APLN was validated by qPCR. 102 genes, 59 up-regulated and 43 down-regulated genes, were significantly differentially expressed in KD groups. GO enrichment analysis showed that DEGs were enriched in cellular response to cytokines, cytokine-mediated signaling pathway, and regulation of immune cells migration and chemotaxis. KEGG signaling pathway analysis showed that DEGs were mainly involved in cytokine−cytokine receptor interaction, chemokine signaling pathway, and TGF−β signaling pathway. Besides, the mRNA expression levels of SMAD1, SMAD6, CD34, CXCL1, and APLN in the KD group were signiﬁcantly up-regulated compared with the normal group, whilePITX2 was significantly down-regulated. Conclusion: 102 DEGs in KD serum-induced HCAECs were identified, and six new targets were proposed as potential indicators of KD.
Microscopic research on the olfactory organ of the Far Eastern brook lamprey Lethenteron reissneri (Pisces, Petromyzontidae)
Authors: Kim Hyun-Tae , Park Jong-Young 
Published: August 2020

Abstract
The olfactory anatomy and histology of Lethenteron reissneri were researched using a stereo microscope, a light microscope, and a scanning electron microscope. As in other lampreys, it shows same characters as follows: i) a single olfactory organ, ii) a single tubular nostril, iii) a single olfactory chamber with gourd-like form, iv) a nasal valve, v) a nasopharyngeal pouch, vi) a sensory epithelium (SE) of continuous distribution, vii) a supporting cells with numerous long cilia, viii) an accessory olfactory organ. However, the description of a pseudostratified columnar layer in the SE and NSE is a first record, not reported in sea lamprey Petromyzon marinus. In particular, both 19 to 20 lamellae in number and olfactory receptor neuron’s quarter ciliary length of the knob diameter differ from those of P. marinus. From these results, it might be considered that the olfactory organ of L. reissneri shows well adaptive structure of a primitive fish to slow flowing water with gravel, pebbles, and sand and a hiding habit into sand bottom at daytime. The lamellar number and neuron’s ciliary length may be a meaningful taxonomic character for the class Petromyzonida.
Achieving SDG 3.8.2: Financial Protection Against Catastrophic Health Expenditure in Malaysia
Authors: Sukeri Surianti , Sayuti Muaz 
Published: August 2020

Abstract
Background: The Sustainable Development Goal (SDG) 3.8.2 is one of the two indicators to monitor a country's progress towards universal health coverage. It concerns the financial protection against catastrophic spending on health based on the budget share approach. The purpose of this study is twofold: 1) to measure SDG 3.8.2 on the proportion of households with catastrophic health expenditure (CHE), and 2) to determine households at risk of CHEMethods: A cross-sectional study was conducted using secondary data from the 2015/2016 Household Expenditure Survey. The inclusion criterion was Malaysian households with some health spending in the past 12 months before the date of the survey. The World Health Organization method of calculating CHE was applied in the calculation, and a threshold of 10% out-of-pocket health spending from total household expenditures was used to determine CHE. Data were analysed descriptively, and multiple logistic regression was used to determine factors associated with CHE.Results: A total of 13015 households were involved in the study. The proportion of CHE was 2.8%. Four associated factors that were statistically significant were female-headed household (Adjusted OR 1.6; CI 1.25, 2.03; p-value <0.001), household that lived in rural area (Adjusted OR 1.29; 95% CI 1.04, 1.61; p-value =0.022), small household size (Adjusted OR 2.4; 95% CI 1.81, 3.18; p-value <0.001) and head of household aged below 60 years old (Adjusted OR2.34; 95% CI 1.81, 3.18; p-value <0.001).Conclusions: The low proportion of CHE revealed that Malaysia is on the right track towards achieving SDG 3.8 on universal health coverage status by 2030. However there is an increasing trend in the proportion of CHE. Households at risk of CHE require financial protection to afford healthcare and safety net measures to prevent from spiralling further into the vicious cycle of illness and poverty.