bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the care providers version of the Rainbow Model of Integrated Care-Measurement Tool in Chinese primary care systems
Authors: Huang Yixiang , Zhu Paiyi , Chen Lijin , Wang Xin , Valentijn Pim 
Published: January 2020

Abstract
Background: The original Rainbow Model of Integrated Care Measurement Tool (RMIC-MT) is based on the Rainbow Model of Integrated Care, which provides a comprehensive theoretical framework for integrated care. To translate and adapt the original care provider version of the Rainbow Model of Integrated Care-Measurement Tool and evaluate its psychometric properties by a pilot study in Chinese primary care systems.Methods: The translation and adaptation process were performed in four steps, forward and back-translation, expert review and pre-testing. We conducted a cross-sectional study with 1610 community care professionals in all 79 community health stations in the Nanshan district. We analyzed the distribution of responses to each item to study the psychometric sensitivity. Exploratory factor analysis with principal axis extraction method and promax rotation was used to assess the construct validity. Pearson’s correlation was used to assess concurrent validity. Cronbach’s alpha was utilized to ascertain the internal consistency reliability. Lastly, confirmation factor analysis was used to evaluate the exploratory factor analysis model fit.Results: During the translation and adaptation process, all 55 items were retained with some detailed modifications. No item was found to have psychometric sensitivity problems. Eight factors were determined by exploratory factor analysis, accounting for 66.41% of the total variance. According to exploratory factor analysis and discussion with all authors, the original ten dimensions were adjusted to nine dimensions in the Chinese version. A standard Cronbach’s alpha of 0.960 and significant correlation among all items in the scale (>0.4) showed good internal consistency reliability of the tool. And, the model passed the majority of goodness-to-fit test by confirmation factor analysis Conclusions: The results showed initial satisfactory psychometric properties for the validation of the RMIC-MT care provider version. Its application in China will promote the development of people-centered integrated primary care. However, further psychometric testing is needed in multiple primary care settings with both public and private community institutes.
Modified Carbon Nanostructures Obtained from Sugarcane Bagasse Hydrochar for Treating Chromium-polluted Water
Authors: Fathy Nady A. , El-Khouly Sahar M. , El-Shafey Ola I. 
Published: January 2020

Background:
Application of nanotechnology in wastewater treatment is the solution to
cope with the conflict between people’s increasing demand for water and the world-wide water
shortage. The main goal of this study is to prepare modified carbon nanostructures (CNSs) from sugarcane
bagasse waste (SCB) as effective adsorbents for removing toxic Cr(VI) ions from their aqueous
solutions.

Methods:
The preparation of CNSs was performed via catalytic hydrothermal/carbonization of SCB.
The resultant CNSs sample was oxidized by oxidation with HNO3/H2O2 (O-CNSs) and then followed
by coating with diethylenetriamine (N-CNSs). Transmission electron microscope (TEM), scanning
electron microscope attached to energy-dispersive X-ray (SEM/EDX), fourier transform infrared
(FTIR) and nitrogen adsorption analyses were used to determine the morphology and surface properties
of CNSs. Adsorption and desorption studies of Cr(VI) ions onto these modified CNSs were investigated.
Effects of initial concentration of Cr(VI), pH of solution and temperature in the batch
mode were estimated. Adsorption studies were analyzed by Langmuir, Freundlich and Dubinin-
Radushkevich models. Pseudo-first-order, pseudo-second-order and intraparticle diffusion models
were undertaken to follow the adsorption mechanism.

Results:
The prepared samples composed of carbon nanotubes and graphene sheets were evident by
TEM and SEM. The adsorption of Cr(VI) is exothermic in nature, well-fitted with Langmuir, described
by pseudo-second order kinetic model and then is uncontrolled by intraparticle diffusion step.
It was found that the adsorption of Cr(VI) was higher uptake over O-CNSs (56 mg/g) than that by NCNSs
(44 mg/g). This was ascribed to that the first sample is enriched with acidic O-functional
groups and possessed higher specific surface area (188 m2/g). Desorption studies were achieved by
HNO3 and NaOH reagents for recovering the Cr(VI) from O-CNSs. Results revealed that about 90%
of Cr(VI) can be recovered by HNO3 more than that by NaOH till the third run.

Conclusions:
Two modified CNSs samples were successfully prepared from SCB. Adsorption of
Cr(VI) is highly relied on initial concentration of Cr(VI), pH and temperature. The main factors controlling
the adsorption behavior of Cr(VI) are the acidic functional groups and the accessible surface
area on O-CNSs. Furthermore, the O-CNSs attained high stability in recycling tests for Cr(VI) removal.
Removal of Toxic Dyestuffs from Aqueous Solution by Amphoteric Bioadsorbent
Authors: El-Shishtawy Reda M. , Asiri Abdullah M. , Ahmed Nahed S.E. 
Published: January 2020

Background:
Color effluents generated from the production industry of dyes and pigments
and their use in different applications, such as textile, paper, leather tanning, and food industries,
are high in color and contaminants that damage the aquatic life. It is estimated that about 105 of
various commercial dyes and pigments amounted to 7×105 tons are produced annually worldwide.
Ultimately, about 10-15% is wasted into the effluents of the textile industry. Chitin is abundant in nature,
and it is a linear biopolymer containing acetamido and hydroxyl groups amenable to render it
atmospheric by introducing amino and carboxyl groups, hence able to remove different classes of
toxic organic dyes from colored effluents.

Methods:
Chitin was chemically modified to render it amphoteric via the introduction of carboxyl
and amino groups. The amphoteric chitin has fully been characterized by FTIR, TGA-DTG, elemental
analysis, SEM, and point of zero charges. Adsorption optimization for both anionic and cationic
dyes was made by batch adsorption method, and the conditions obtained were used for studying
the kinetics and thermodynamics of adsorption.

Results:
The results of dye removal proved that the adsorbent was proven effective in removing both
anionic and cationic dyes (Acid Red 1 and methylene blue (MB)), at their respective optimum pHs (2
for acid and 8 for cationic dye). The equilibrium isotherm at room temperature fitted the Freundlich
model for MB, and the maximum adsorption capacity was 98.2 mg/g using 50 mg/l of MB, whereas
the equilibrium isotherm fitted the Freundlich and Langmuir model for AR1 and the maximum adsorption
capacity was 128.2 mg/g. Kinetic results indicate that the adsorption is a two-step diffusion
process for both dyes as indicated by the values of the initial adsorption factor (Ri) and follows the
pseudo-second-order kinetics. Also, thermodynamic calculations suggest that the adsorption of AR1
on the amphoteric chitin is an endothermic process from 294 to 303 K. The result indicated that the
mechanism of adsorption is chemisorption via an ion-exchange process. Also, recycling of the adsorbent
was easy, and its reuse for dye removal was effective.

Conclusion:
New amphoteric chitin has successfully been synthesized and characterized. This resin
material, which contains amino and carboxyl groups, is novel as such chemical modification of chitin
hasn’t been reported. The amphoteric chitin has proven effective in decolorizing aqueous solution
from anionic and cationic dyes. The adsorption behavior of amphoteric chitin is believed to follow
chemical adsorption with an ion-exchange process. The recycling process for few cycles indicated
that the loaded adsorbent could be regenerated by simple treatment and retested for removing anionic
and cationic dyes without any loss in the adsorbability. Therefore, the study introduces a new and
easy approach for the development of amphoteric adsorbent for application in the removal of different
dyes from aqueous solutions.
How Molecular Epidemiology Can Affect Tuberculosis Control in the Middle East Countries: A Systematic Review and Meta-Analysis
Authors: Asgharzadeh Mohammad , Rashedi Jalil , Poor Behroz Mahdavi , kafil Hossein Samadi , Zadeh Hossein Moharram , Ahmadpour Ehsan 
Published: January 2020

Background:
Nowadays, due to the incidence of specific strains of Mycobacterium tuberculosis
and also an increase in the rate of drug resistant-TB, the mortality rate has been increased
by this disease. The identification of common strains in the region, as well as the sources of transmission,
is essential to control the disease, which is possible by using molecular epidemiology.

Objective:
In this survey, the studies utilizing the spoligotyping method in Muslim Middle East
countries are reviewed to determine their role in the control of TB.

Methods:
All studies conducted from 2005 to June 2016 were considered systematically in three
electronic databases out of which 23 studies were finally selected.

Results:
The average rate of clustering was 84% and the rate of recent transmission varied from
21.7% to 92.4%. The incidence of Beijing strains has been found to be rising in the abovementioned
countries. In Iran and Saudi Arabia known as immigration and labour-hosting countries,
respectively, rapid transmittable and drug-resistant Beijing strains were higher than those in other
Muslim Middle East countries.

Conclusion:
Considering the incidence of highly virulent strains, due to the increase in immigration
and people infected with HIV, tuberculosis, especially drug-resistant form, careful monitoring is
needed.
Time-Frequency Spectral Power Assessment of Rolling Element Bearing Faults Using Adaptive Modified Morlet Wavelet Transform
Authors: Yadav Om P. , Pahuja Gobind L. 
Published: January 2020

Objectives:
The main objectives of this manuscript are to investigate and diagnose
rolling element bearing defects in its inception time.

Methods:
Vibration signal generated by the induction motor contains a series of frequency components
that have rich and viable information about bearing health conditions. Recently, the Maximum
Energy Concentration (MEC), measure of time-frequency spectrum has been employed to investigate
the small variations in low frequency biomedical signal spectrum. In this paper, the above technique
has been modified and applied to study the bearing defects of induction motor using vibration
signal and it is termed as Adaptive Modified Morlet Wavelet (AMMW) transform. Initially, this
proposed method was validated on two medium frequency synthetic time series signals in terms of
MEC measurement at different Signal to Noise Ratio (SNR).

Results:
The simulated results have depicted that the AMMW method provides excellent timefrequency
localization capability over other time-frequency methods like Morlet wavelet transform,
modified Morlet wavelet transform, adaptive S-transform and adaptive modified S-transform. Then,
this method has been applied to the standard database of vibration signal to determine interquartile
power for fault detection purpose and also fault index parameter termed as IFI has been analyzed to
detect small variation in vibration signals.
ПРЕДИКТОРИ ТРОМБОЗІВ ШУНТІВ У ПАЦІЄНТІВ З АТЕРОСКЛЕРОТИЧНИМИ ОКЛЮЗІЙНО-СТЕНОТИЧНИМИ УРАЖЕННЯМИ АРТЕРІЙ НИЖНІХ КІНЦІВОК
Authors: Сабадош Р. В. , Решетило В. А. , Совтус О. Ф. , Мотуз В. В. , Сарапук С. В. , Ризюк Н. М. 
Published: January 2020

Резюме. Метою дослідження стало покращення лікування пацієнтів з облітеруючим атеросклерозом нижніх кінцівок, яким проводяться відкриті шунтуючі оперативні втручання на артеріях, шляхом вивчення частоти та причин тромбозів шунтів після реконструктивних операцій на різних артеріальних сегментах. Впродовж 3 років динамічно спостерігалися 93 такі хворі. У 81 хворого були виконані «одноповерхові» артеріальні реконструктивні втручання і у 12 – «двоповерхові». Було виявлено, що в осіб, у яких упродовж спостереження шунти затромбувалися, швидкість агрегації тромбоцитів та рівень фактора Віллебранда перед операцією були статистично значуще вищими, ніж у хворих без тромбозів шунтів (р=0,037 та 0,048). Частота тромбозів шунтів була також статистично значуще вищою у осіб з доопераційним активованим частковим тромбопластиновим часом, відхиленим у бік гіперкоагуляції (р=0,039). Серед осіб зі стенозами 50-70 % в аорто-клубовому сегменті та протяжними оклюзіями у стегново-підколінному сегменті, яким реконструктивні операції виконували лише на стегново-підколінному сегменті, частота тромбозів шунтів виявилася статистично значуще вищою, ніж у осіб, у яких стенози в аорто-клубовому сегменті були попередньо ліквідовані шляхом стентування зовнішньої чи загальної клубової артерії (р=0,041). Було також встановлено, що при відсутності адекватної вени, для стегново-підколінних шунтувань з дистальним анастомозом вище коліна допустимо використовувати алошунтування, а для стегново-гомілкових реконструкцій – алоаутошунтування. Проведення нового дослідження з вивченням частоти тромбозів шунтів у випадку протидії виявленим у цій праці предикторам може зумовити суттєве покращення результатів лікування таких хворих.
МЕХАНІЗМ РОЗВИТКУ ТАКСАН-ІНДУКОВАНИХ НЕЙРОФІЗІОЛОГІЧНИХ ЗМІН У ОНКОЛОГІЧНИХ ХВОРИХ
Authors: Голотюк І. С. , Крижанівська А. Є. , Голотюк В. В. , Андріїв А. В. , Голотюк С. І. 
Published: January 2020

Резюме. Хіміотерапевтично-індукована периферична нейропатія є дозолімітуючим побічним нейротоксичним ефектом цілого ряду хіміопрепаратів, серед яких препарати платини, таксани, алкалоїдні препарати, а також нові таргетні препарати, зокрема бортезамід та ленолідамід. Типовим шляхом попередження периферичної нейропатії є редукція доз хіміопрепаратів або відмова від застосування таксанів, що, у свою чергу, негативно позначається на безпосередній ефективності та віддалених результатах лікування. Периферична нейропатія, викликана таксанами, негативно впливає на довготривалу якість життя пацієнтів, характеризується тривалим персистуючим перебігом та в 40 % випадків призводить до інвалідизації.
Патофізіологічний механізм таксан-індукованої нейропатії на даний час не є цілковито розкритим та зрозумілим. Пригнічення деполяризації тубуліну і, як наслідок, дисфункція мікротрубочок наразі є найбільш загальноприйнятим поясненням нейротоксичності таксанів. Даних морфологічного дослідження периферичних нервів у пацієнтів у науковій літературі бракує. Біопсія литкового нерва (nervus suralis) із наступним вивченням морфологічних змін при застосуванні паклітакселу та доцетакселу проводилась тільки у декількох пацієнтів. Більше того, вичерпні дані морфологічного дослідження неоднозначні та суперечать загальноприйнятій теорії патогенезу нейропатії.
Для того, щоб своєчасно та ефективно попереджати і запобігати дану побічну реакцію, необхідно знати причини, що призводять до розвитку периферичної нейропатії, і розуміти, які клітинні структури і механізми беруть у цьому участь. У даній статті наведено огляд літературних даних, присвячених питанню розвитку периферичної нейропатії, індукованої таксанами.
Penyuluhan Hukum Tentang Merugikan Keuangan Negara Kepada Kepala Desa se-Kecamatan Pemayung Kabupaten Batang Hari Guna Pencegahan Korupsi Pada Pemerintahan Desa
Authors: Lasmadi Sahuri , Sudarti Elly 
Published: January 2020

Kegiatan pengabdian ini bertujuan untuk: (1). Meningkatkan pengetahuan dan pemahaman Mitra Kepala Desa beserta Perangkat Desa tentang UU Pemberantasan Tindak Pidana Korupsi dan Perda Kab. Batang Hari Tentang Pengelolaan Keuangan Desa; (2). Meningkatkan kemampuan Mitra dalam menyampaikan ide pemikiran kegiatan terkait dengan pencegahan tindak pidana korupsi pada pemerintahan desa; Kegiatan pengabdian ini dilatarbelakangi maraknya perilaku korupsi yang berkaitan dengan kerugian keuangan negara yang dilakukan oleh Penyelenggara Negara. Kepala Desa adalah pemegang kekuasaan penyelenggaraan pemerintahan desa. Permasalahannya adalah masih kurangnya tingkat pengetahuan dan pemahaman Mitra terhadap UU Pemberantasan Tindak Pidana Korupsi; dan Perda Kab. Batang Hari Tentang Pengelolaan Keuangan Desa; dan akibat-akibat hukum jika terjadi penyalahgunaan pengelolaan keuangan desa. Metode yang digunakan adalah metode partisipatif diharapkan mitra dapat berperan aktif dalam kegiatan penyuluhan hukum dalam bentuk (1) Ceramah Sosialisasi UU Pemberantasan Tindak Pidana Korupsi; dan Perda Kab. Batang Hari Tentang Pengelolaan Keuangan Desa; (2) Penyuluhan hukum tentang isi UU Pemberantasan Tindak Pidana Korupsi; dan Perda Kab. Batang Hari Tentang Pengelolaan Keuangan Desa dan akibat-akibat hukum jika terjadi penyalahgunaan pengelolaan keuangan desa. Kesimpulan: “Penyuluhan Hukum Tentang Merugikan Keuangan Negara Kepada Kepala Desa Se Kecamatan Pemayung Kabupaten Batang Hari Guna Pencegahan Korupsi Pada Pemerintahan Desa”, menunjukkan bahwa akseptabilitas yakni tingkat penyerapan mitra terhadap kegiatan mengalami peningkatan yang diukur dari tingkat pengetahuan dan pemahaman tentang materi kegiatan. Yaitu adanya peningkatan pengetahuan dan pemahaman peserta tentang isi Undang-Undang Nomor 31 Tahun 1999 jo UU No 20 Tahun 2001 Tentang Pemberantasan Tindak Pidana Korupsi, Peraturan Daerah Nomor 11 Tahun 2012 Tentang Pengelolaan Keuangan Desa. serta mampu menyampaikan ide atau pemikiran berkaitan dengan Pencegahan secara dini tindak pidana korupsi di kalangan Perangkat Desa. Saran: Kegiatan penyuluhan sangat bermanfaat bagi masyarakat, khususnya Perangkat Desa tentang masalah korupsi. Kegiatan penyuluhan dapat dilakukan secara berkelanjutan dan terencana.
Landing Biomechanics, But Not Physical Activity, Differ in Young Male Athletes With and Without Patellar Tendinopathy
Authors: Pietrosimone Laura S. , Blackburn J. Troy , Wikstrom Erik A. , Berkoff David J. , Docking Sean I. , Cook Jill , Padua Darin A. 
Published: January 2020

Objective To examine differences in biomechanical and physical activity load in young male athletes with and without patellar tendinopathy. Design Cross-sectional cohort study. Methods Forty-one young male athletes (15–28 years of age) were categorized into 3 distinct groups: symptomatic athletes with patellar tendon abnormalities (PTA) (n = 13), asymptomatic athletes with PTA (n = 14), and a control group of asymptomatic athletes without PTA (n = 14). Participants underwent a laboratory biomechanical jump-landing assessment and wore an accelerometer for 1 week of physical activity monitoring. Results The symptomatic group demonstrated significantly less patellar tendon force loading impulse in the involved limb compared with both the control and asymptomatic groups (P<.05), with large effects (d = 0.91–1.40). There were no differences in physical activity between the 3 groups (P>.05). Conclusion Young male athletes with symptomatic patellar tendinopathy demonstrated smaller magnitudes of patellar tendon force loading impulse during landing compared to both asymptomatic athletes with patellar tendinopathy and healthy control participants. However, these 3 distinct groups did not differ in general measures of physical activity. Future investigations should examine whether comprehensively monitoring various loading metrics may be valuable to avoid both underloading and overloading patterns in athletes with patellar tendinopathy. J Orthop Sports Phys Ther 2020;50(3):158–166. Epub 6 Jan 2020. doi:10.2519/jospt.2020.9065
Hip Kinematics During Single-Leg Tasks in People With and Without Hip-Related Groin Pain and the Association Among Kinematics, Hip Muscle Strength, and Bony Morphology
Authors: Harris-Hayes Marcie , Hillen Travis J. , Commean Paul K. , Harris Michael D. , Mueller Michael J. , Clohisy John C. , Salsich Gretchen B. 
Published: January 2020

Objective To compare 3-D hip kinematics during the single-leg squat and step-down in patients with hip-related groin pain to those in asymptomatic participants, and to assess relationships among hip kinematics, muscle strength, and bony morphology. Design Controlled laboratory cross-sectional study. Methods Forty patients with hip-related groin pain and 40 matched, asymptomatic participants between 18 and 40 years of age participated. A handheld dynamometer was used to assess hip abductor and external rotator strength. An 8-camera motion-analysis system was used to quantify 3-D kinematics during the single-leg squat and step-down. Magnetic resonance imaging was used to quantify bony morphology. The independent t test and Mann-Whitney U test were used to assess between-group differences. Pearson coefficient correlations were used to assess relationships. Results Patients with hip-related groin pain had smaller peak hip flexion angles, smaller knee flexion angles, and lesser squat depth compared to asymptomatic participants during the single-leg squat. Among patients with hip-related groin pain, smaller hip flexion angles during the single-leg squat were associated with hip abductor weakness (r = 0.47, P≤.01). Among asymptomatic participants, smaller peak hip flexion angles during the single-leg squat were associated with less acetabular coverage (r = 0.33, P = .04) and shallow squat depth (r = 0.48, P≤.01); a smaller hip internal rotation angle during the step-down was associated with larger femoral neck shaft angle (r = −0.43, P<.01). Conclusion Compared to asymptomatic participants, patients with hip-related groin pain had smaller hip and knee flexion angles and shallower squat depth during the single-leg squat. Smaller hip flexion angles were associated with hip abductor weakness among those with hip-related groin pain. J Orthop Sports Phys Ther 2020;50(5):243–251. Epub 6 Jan 2020. doi:10.2519/jospt.2020.9150
In-vivo studies of metformin modified release formulations
Authors: Nagarajan Janaki Sankarachari Krishnan  , Elango Kannan  
Published: January 2020

The current study was undertaken to conduct In vivo studies and to establish the new validated bioanalysis for the determination of Metformin present in Blood Plasma by using the Reverse Mode-LC Method. The separation of the Metformin was carried out on Reverse mode LC using Shimadzu® LC - 10AT with the following Stationary Phase: Kromasil octadecyl silane column (25 cm x 4.6 mm i.d., 5µm) Eluent: Cyanomethane: 25 mM Pentane Sulfonic acid of pH 3.5. ratio 09:91 % v/v with 1.0 ml/min flow rate has been fixed, and this has been measured at 232 nm, and the sample volume will be 10 ul using Rheodyne 7725i injector. Based on the method established for Metformin, the drug peak is well resolved at 11.11 min and validated as per US FDA guidelines with respect to linearity, accuracy, precision, robustness ruggedness, and stability. The calibration curve was found to be linear over a range of 0.025 –1 μg/mL (r2 = 0.9999). The method has proved high sensitivity and specificity. Established method have been used to quantify the Pharmacokinetic parameters like Cmax, Tmax, AUC0-t & AUC0-∞, Keli, and t1/2 studied and the values for reference formulation (660.05±91.52 ng/ml, 4.46 ±1.10 h, 8280.41 ± 1356.39 ng.h/ml, 9200.31± 1569.26 ng.h/ml, 0.11±0.03 h-1, and 6.96±1.53 h respectively) and the test formulation ( 705.06±102.58 ng/ml, 4.13±0.74 h, 8185.21±2101.56 ng.h/ml, 8946.39± 2457.66 ng.h/ml, 0.12±0.03 h-1, and 6.06±1.61 h, respectively) were compared and found to be biologically equivalent. Based on the Pharmacokinetic and statistical analysis Test formulation of Metformin Hydrochloride containing 500 mg Metformin Hydrochloride (modified release formulations) is biologically equivalent to that of the Reference.