bluuebunny/crossref_metadata_2025_split huggingface dataset:
How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing
Authors: McGeoch Paul D. , Rouw Romke 
Published: November 2020

AbstractWe propose that synesthetic cross‐activation between the primary auditory cortex and the anatomically adjacent insula may help explain two puzzling conditions—autonomous sensory meridian response (ASMR) and misophonia—in which quotidian sounds involuntarily trigger strong emotional responses. In ASMR the sounds engender relaxation, while in misophonia they trigger an aversive response. The insula both plays an important role in autonomic nervous system control and integrates multiple interoceptive maps representing the physiological state of the body to substantiate a dynamic representation of emotional wellbeing. We propose that in ASMR cross‐activation of the map for affective (sensual) touch leads to an increase in subjective wellbeing and parasympathetic activity. Conversely, in misophonia the effect of the cross‐activation is to decrease emotional wellbeing and increase sympathetic activity. Our hypothesis also illuminates the connection between hearing and wellbeing more broadly and helps explain why so many people experience decreased wellbeing from modern urban soundscapes.
How environmental innovation influences firm performance: A meta‐analytic review
Authors: Hizarci‐Payne Ayça Kubra , İpek İlayda , Kurt Gümüş Gülüzar 
Published: November 2020

AbstractCoupled with the increasing concern toward sustainability and sustainable development issues, environmental innovation practices have been of burgeoning interest among both scholars and practitioners. Building on this, the main purpose of this study is to quantitatively aggregate the extant empirical research on eco‐innovation and firm performance and to assess the role of moderating factors in this theoretical relationship by pursuing a meta‐analytic approach. To serve this objective, 196 effects based upon 70 studies including more than 25,000 firms (N = 25,412) were meta‐analytically examined. Quantitative evidence drawn from the meta‐analysis indicates that organizational eco‐innovation exerts the strongest influence on firm performance. Moreover, the meta‐analytic findings suggest that significant variations in the correlation between eco‐innovation and firm performance exist across different performance types, and the magnitude of the eco‐innovation–firm performance association is stronger in developing compared with developed countries. This meta‐analytic review is expected to considerably contribute to the pertinent literature by means of improving the understanding of the relevance of eco‐innovation typology to firm performance.
Usefulness of updated logistic clinical SYNTAX score based on MI‐SYNTAX score in patients with ST‐elevation myocardial infarction
Authors: Kawashima Hideyuki , Hara Hironori , Wang Rutao , Ono Masafumi , Gao Chao , Takahashi Kuniaki , Suryapranata Harry , Walsh Simon , Cotton James , Carrie Didier , Sabate Manel , Steinwender Clemens , Leibundgut Gregor , Wykrzykowska Joanna , Hamm Christian , Jüni Peter , Vranckx Pascal , Valgimigli Marco , Windecker Stephan , de Winter Robbert J. , Sharif Faisal , Onuma Yoshinobu , Serruys Patrick W. 
Published: November 2020

AbstractObjectivesTo compare the predictive performances of the prewiring, postwiring MI‐SYNTAX scores, prewiring, and postwiring Updated Logistic Clinical SYNTAX score (LCSS) for 2‐year all‐cause mortality post percutaneous coronary intervention (PCI) in ST‐elevation myocardial infarction (STEMI) patients.BackgroundIn patients with STEMI and undergoing primary PCI, coronary stenosis(es) distal to the culprit lesion is often observed after the restoration of coronary flow. To address comprehensively the complex coronary anatomy in these patients, prewiring and postwiring MI‐SYNTAX scores have been reported in the literature. Furthermore, to enable individualized risk estimation for long‐term all‐cause mortality, the Updated LCSS has been developed by combining the anatomical SYNTAX score and clinical factors.MethodsIn the randomized GLOBAL LEADERS trial, anatomical SYNTAX score analysis was performed by an independent angiographic corelab for the first 4,000 consecutive patients as a prespecified analysis; of these, 545 presented with STEMI. The efficacy of the mortality predictions of the four scores at 2 years were evaluated based on their discrimination and calibration abilities.ResultsComplete data was available in 512 patients (93.9%). When the patients were stratified into two groups based on the median of the scores, the prewiring and postwiring Updated LCSSs demonstrated that the high‐score groups were associated with higher rates of 2‐year all‐cause mortality compared to the low‐score groups (6.6 vs. 1.2%; log‐rank p = .001 and 6.6 vs. 1.2%; log‐rank p = .001, respectively). There were no statistically significant differences for predicting the mortality between the prewiring (area under the curve [AUC] 0.625), postwiring MI‐SYNTAX score (AUC 0.614), prewiring (AUC 0.755), and postwiring Updated LCSS (AUC 0.757). In the integrated discrimination improvement (IDI), the prewiring MI‐SYNTAX score had a better discrimination for the mortality than the postwiring MI‐SYNTAX score (IDI ‐0.0082; p = .029). The four scores had acceptable calibration abilities for 2‐year all‐cause mortality.ConclusionsThe prewiring Updated LCSS predicts long‐term all‐cause mortality with clearly useful discrimination and acceptable calibration. Since the postwiring MI‐SYNTAX score does not improve mortality prediction, the prewiring MI‐SYNTAX score may be preferred for the 2‐year mortality prediction using the Updated LCSS.
Fate of glyphosate in wheat during milling and bread production
Authors: Tittlemier Sheryl A. , Bestvater Lianna , Carlson Jules , Kletke Jerry , Izydorczyk Marta , Fu Bin Xiao 
Published: November 2020

AbstractBackground and objectivesGlyphosate is an active ingredient in widely used herbicides; its residues have been observed in grain and grain‐based foods. This work investigated the fate of glyphosate and its degradation product aminomethylphosphonic acid (AMPA) in milling fractions of wheat and during the bread making process. Samples of wheat were pearled to obtain successive fractions representing outer kernel layers. Straight grade flour and bread were prepared from the two samples with the highest glyphosate concentration (2.1 and 2.8 mg/kg).FindingsAll pearling and milling product fractions, dough, fermented dough, bread crust, and bread crumb were analyzed for glyphosate and AMPA using solvent extraction with derivatization and liquid chromatography–tandem mass spectrometry. Glyphosate was the only residue detected in samples. On average, the pearling experiment demonstrated that 50% of the total glyphosate mass resided in the outer 17% of the kernels. Similarly, 81% of the total glyphosate mass in the wheat was associated with the bran, shorts, and feeds milling fractions. No changes in glyphosate concentration were observed during the preparation of dough, fermented dough, and bread.ConclusionsMilling provides the best opportunity for reducing exposure to glyphosate, as the baking process did not affect glyphosate residues. Concentrations in bread made from straight grade flour will be approximately 4× lower than that made from whole grain flour.Significance and noveltyThe use of Canada Western Red Spring from commercial wheat shipments provide realistic glyphosate residue concentrations and also reflect the predominance of this type of wheat used in Canada and elsewhere for bread. Therefore, the outcomes from this study are particularly relevant for estimating consumers’ dietary exposure.
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: Successful treatment for new and rare entity
Authors: Jerbi Mouna , El Fatmi Rym , Gaied Hanene , Belloumi Dorra , Torjemane Lamia , Aoudia Raja , Goucha Rim , Abdallah Taieb Ben , Othman Tarek Ben 
Published: November 2020

AbstractProliferative glomerulonephritis with monoclonal immunoglobulin deposits is a new disorder with undefined treatment modalities. We propose cyclophosphamide‐bortezomib‐dexamethasone and autologous stem cell transplantation as a therapeutic protocol.
Digital surgical planning and placement of osseointegrated implants to retain an auricular prosthesis using implant software with cone‐beam computed tomography and 3D‐printed surgical guides: A case report
Authors: Domingue Daniel , Sinada Naif , White James R. 
Published: November 2020

AbstractIntegration of CBCT imaging with dental implant treatment planning software and 3D‐printed surgical guides can facilitate surgical planning for extraoral implant placement. In the current case, this combined planning strategy enabled navigation of challenging osseous anatomy, avoided critical structures, and optimized osseointegration for prosthesis retention.
Cochlear implantation in a patient with a POU4F3 mutation
Authors: Miyake Keitaro , Shirai Kyoko , Nishiyama Nobuhiro , Kawaguchi Sachie , Ohta Yoko , Kawano Atsushi , Usami Shin‐ichi , Kitano Tomohiro , Tsukahara Kiyoaki 
Published: November 2020

AbstractCochlear implants (CIs) are generally considered useful in the treatment of hereditary hearing loss with progressive deafness. Early CI can be beneficial for maintaining social activities in POU4F3 mutation patients.
Heat Integration in Straight‐Through Sulfur Recovery Units to Increase Net High‐Pressure Steam Production
Authors: Jagannath Anoop , Ibrahim Salisu , Raj Abhijeet 
Published: November 2020

AbstractEnergy conservation is of paramount importance in oil and gas industries. Sulfur recovery units (SRUs) in oil and gas industries are required to meet the stringent environmental emission regulations, and are often viewed as production costs. They are normally net energy exporters and a considerable portion of heat is recovered as high‐pressure steam. However, SRUs processing lean acid gas streams require significant amounts of acid gas and air preheating before they enter the reaction furnace. Some portion of the generated high‐pressure steam is used in preheating these streams. This reduces the overall net high‐pressure steam generated from the SRU. Here, heat integration is used and an existing SRU facility is retrofitted such that there is an increase in net high‐pressure steam production. Seven new heat‐integrated SRU configurations are proposed, and key aspects such as net high‐pressure steam production, investment costs, and payback period for each of the new retrofitted configurations are compared.
An accurate numerical method for inversion of Laplace transforms with applications in process dynamics and control
Authors: Fatoorehchi Hooman 
Published: November 2020

AbstractLaplace transforms are frequently used in the design of control structures for chemical engineering processes. In this paper, we have developed a novel numerical method to invert Laplace transforms, which involves a particular system of linear algebraic equations. We have proven that the error of our method is bounded, and the proposed formula asymptotically converges to the exact intended Laplace inverse function. A set of numerical simulations have been carried out to demonstrate the efficiency and reliability of our method. As a salient advantage, in addition to its high accuracy, our method requires the Laplace transform function to be defined only on the real axis.
Preoperative predictive factors of carcinoma in situ in the normal‐appearing mucosa in patients who underwent an initial transurethral resection for non‐muscle‐invasive bladder cancer under white light cystoscopy
Authors: Iinuma Koji , Yuhara Kazuya , Kotaka Hiroto , Ozawa Kaori , Kato Daiki , Takai Manabu , Nakane Keita , Mizutani Kosuke , Tsuchiya Tomohiro , Koie Takuya 
Published: November 2020

AbstractBackgroundAlthough few studies evaluated the significance of random biopsies under white light cystoscopy (WLC) in patients with non‐muscle‐invasive bladder cancer (NMIBC), the findings are controversial.AimThis aim of this study was to evaluate what kind of preoperative covariates were useful as predictive factors in detecting carcinoma in situ (CIS) from normal‐appearing mucosa using random bladder biopsies under WLC.Methods and ResultsA total of 229 patients with NMIBC underwent initial TUR followed by random biopsies under WLC at Red Cross Takayama Hospital between 2007 and 2016. These patients underwent TUR with complete resection of intravesical visible tumors followed by random biopsies of normal‐appearing mucosa. In this study, random bladder biopsies of normal‐appearing urothelial mucosa, excluding abnormal mucosa, were carried out with a cold punch in the selected intravesical sites. The covariates included age, gender, the urine cytology result, presence of an abnormal mucosa, number of tumors, size of the largest tumors, configuration of the tumor, and tumor type. Abnormal mucosa was defined as reddish or mossy areas at the time of TUR under WLC. The primary endpoint was to determine what kind of preoperative covariates were useful as predictive factors in detecting CIS from normal‐appearing mucosa using random bladder biopsies under WLC. Finally, 212 patients were evaluated, and 67 patients (31.6%) were diagnosed with CIS from normal‐appearing mucosa. In univariate analysis, positive urine cytology, abnormal mucosa, and the number of tumors were significantly associated with concomitant CIS. On multivariate analysis, positive urine cytology and abnormal mucosa were significantly associated with CIS.ConclusionThe patients who were diagnosed with positive urine cytology or abnormal mucosa by WLC are ideal candidates for TUR followed by random biopsy of normal‐appearing mucosa.
Strong foraging preferences for Ribes alpinum (Saxifragales: Grossulariaceae) in the polyphagous caterpillars of Buff‐tip moth Phalera bucephala (Lepidoptera: Notodontidae)
Authors: Morimoto Juliano , Pietras Zuzanna 
Published: November 2020

Abstract

Herbivorous insects such as butterflies and moths are essential to natural and agricultural systems due to pollination and pest outbreaks. However, our knowledge of butterflies' and moths' nutrition is fragmented and limited to few common, charismatic, or problematic species.

This gap precludes our complete understanding of herbivorous insects' natural history, physiological and behavioral adaptations that drive how species interact with their environment, the consequences of habitat fragmentation and climate change to invertebrate biodiversity, and pest outbreak dynamics.

Here, we first report a population of the Buff‐tip moth Phalera bucephala (Lepidoptera: Notodontidae) feeding on a previously unknown family of host plants, the mountain currant Ribes alpinum (Saxifragales: Grossulariaceae). This is the first report of a Notodontid moth feeding on Grossulariaceae hosts.

Using no‐choice and choice assays, we showed that P. bucephala has strong foraging preferences for a previously unknown hosts, the R. alpinum but also, although to a smaller extent, R. uva‐crispa compared with a previously known host (the Norway maple Acer sp.).

These findings demonstrate that P. bucephala feed on—and show strong preference for Grossulariaceae host plants, indicating flexible physiological mechanisms to accommodate hosts plants from various families. This makes this species a potential model organism to study the behavioral and physiological mechanisms underpinning insect–plant interactions and diet breadth evolution.

We discuss the broad ecological implications of these observations to the biology of the species, the potential negative effects of interspecific competition with endemic specialist moths, and highlight questions for future research.
Prevalence of prediabetes, and diabetes in Chandigarh and Panchkula region based on glycated haemoglobin and Indian diabetes risk score
Authors: Kumar Saurabh , Anand Akshay , Nagarathna Raghuram , Kaur Navneet , Sivapuram Madhava Sai , Pannu Viraaj , Pal Deepak Kumar , Malik Neeru , Singh Amit Kumar , Nagendra Hongasandra Ramarao 
Published: November 2020

AbstractThere is a rapid increase in the prevalence of diabetes in India. We wanted to review the status of prediabetes and diabetes in the combined population of Chandigarh and Panchkula region based on both Indian Diabetes Risk Score (IDRS) and Glycated Haemoglobin (HbA1c). A total of 1215 subjects were recruited during the screening process, out of which 444 i subjects have been analysed for the current study on the basis of high risk for IDRS (≥60) and their known diabetes status. This study included 431 subjects having high risk for IDRS (≥60) and 13 known subjects with diabetes (IDRS < 60) which were further analysed for biochemical and anthropometric parameters. The prevalence of diabetes was found to be 12.67% and prediabetes 11.69% in the combined population of Chandigarh and Panchkula. There was an increased level of fasting blood glucose (183.12 ± 68.61), postprandial blood glucose (262.57 ± 96.92), triglyceride (193.84 ± 119.88), very low‐density lipoprotein (VLDL) (34.87 ± 15.42) and High Density Lipoprotein(HDL) (4.61 ± 1.39) in the said diabetes population. Mean HDL was found to be decreased in subjects having diabetes. Glucose‐induced lipid intolerance study revealed significant alteration in triglyceride, HDL and VLDL. The study has revealed that high prevalence of diabetes in the sampled population when compared with the national average of 8.8%.
Instability mechanism and control of hybrid electric vehicle in initial hybrid driving mode
Authors: Hu Donghai , He Ren , Wang Jing , Hu Leli , He Chengkun 
Published: November 2020

SummaryMode transition is capable of improving the economy of hybrid electric vehicles but may also cause potential crises. When the hybrid power system (hybrid powertrain—HPT) has just completed the mode conversion, the driving system parameters change more dramatically, and the engine torque is fully transferred to the driving motor. Owing to the electromechanical coupling characteristics, HPT may be severely impacted during the operation, causing the instability of initial hybrid drive mode. To solve this problem, the mathematical model of the initial hybrid drive model for a series‐parallel hybrid electric vehicle (SPHEV) is constructed. The local stability condition and bifurcation condition were derived to analyse the influence of engine throttle opening, and the instability threshold of the HPT was given. Moreover, an instability control methodology was designed to optimise the operating region of HPT for the initial hybrid drive mode, and vehicle tests of mode transition were carried out based on the existing SPHEV platform. Studies indicate that different throttle opening may lead to changes in bifurcation characteristics, causing the system to exhibit nonlinear behaviour and random oscillations. In addition, the control methodology proposed in this study can improve the stable operating region by 37% and restrain the oscillations of HPT.
Mid to late‐life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death
Authors: Robinson Andrew C. , Roncaroli Federico , Davidson Yvonne S. , Minshull James , Heal Calvin , Montaldi Daniela , Payton Antony , Horan Michael A. , Pendleton Neil , Mann David M.A. 
Published: November 2020

AbstractObjectivesEarly diagnosis of Alzheimer's disease (AD) is essential for early interventions. Symptoms of depression could represent a prodromal stage of AD. Very early mood alterations may help to stratify those at highest risk of late‐life AD. We aim to investigate associations between baseline/longitudinal scores for depression, presence of cognitive impairment and/or AD pathology at death.Methods/DesignBetween 1991 and 2015, participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age underwent 10 waves of assessment using the Geriatric Depression Scale (GDS). AD pathology at death was evaluated in 106 eligible cases. Analyses aimed to examine associations between GDS scores, cognitive status and AD pathology (as measured by Braak stage, Thal phase and CERAD).ResultsBaseline GDS scores were significantly higher for those cognitively impaired at death than those cognitively normal. Significantly higher baseline GDS scores were found for those with greater Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) scores than those with lower CERAD scores. Similarly, significantly higher baseline GDS scores were found for those with a greater Braak stage than those with lower tau burden. These correlations remained after controlling for age at death, education and APOE ε4, but were less robust. Mean longitudinal GDS scores associated with cognition but not pathology.ConclusionsGDS scores collected approximately 20 years before death were associated with cognitive status and AD pathology at death. We postulate that early AD‐related pathological change produces raised GDS scores due to an overlapping neural basis with depression, and that this may be considered as an early diagnostic marker for AD.
Long‐term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro
Authors: Farasani Abdullah , Darbre Philippa D. 
Published: November 2020

AbstractExtensive use of triclosan (2,4,4′‐trichloro‐2′‐hydroxydiphenyl ether) as an antimicrobial agent in household and personal care products has resulted in global exposure of the human population. Its presence in human tissues, including milk, and its oestrogen‐disrupting properties raise concerns for an involvement in breast cancer. Because metastatic tumour spread is the main cause of breast cancer mortality, we have investigated the effects of triclosan on cell migration and invasion using three human breast epithelial cell lines and using concentrations comparable with those in human tissues. Long‐term exposure to 10−7 M of triclosan resulted in increased migration and invasion as measured by xCELLigence technology for all three cell lines, for the immortalized but nontransformed MCF‐10F breast epithelial cells (after 28 weeks), the oestrogen‐responsive MCF‐7 breast cancer cells (after 17 weeks) and the oestrogen‐unresponsive MDA‐MB‐231 breast cancer cells (after 20 weeks). The effects were therefore not limited to cancerous cells or to oestrogen‐responsive cells. This was paralleled in the MCF‐10F and MCF‐7 (but not MDA‐MB‐231) cells by a reduction in levels of E‐cadherin mRNA as measured by reverse transcription–polymerase chain reaction (RT‐PCR) and of E‐cadherin protein as measured by western immunoblotting, suggesting a mechanism involving epithelial‐to‐mesenchymal transition. This adds triclosan to the increasing list of ingredients of personal care products that can not only enter human breast tissue and increase cell proliferation but also influence cell motility. If mixtures of components in household and personal care products contribute to increasing cell migration and invasion, then reduction in exposure could offer a strategy for reducing breast cancer spread.