bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clothianidin induces DNA damage and oxidative stress in bronchial epithelial cells
Authors: Atlı Şekeroğlu Zülal , Şekeroğlu Vedat , Aydın Birsen , Kontaş Yedier Seval , İlkun Emre 
Published: April 2020

AbstractClothianidin (CHN) is a member of the neonicotinoid group of insecticides. Its oxidative and DNA damage potential for human lung cells are not known. Therefore, the present study was designed to examine the effects of CHN on DNA damage and oxidative stress in human bronchial epithelial cells (BEAS‐2B) treated with CHN for 24, 72, and 120 hr. Our results indicate that CHN decreased cell viability in a concentration‐dependent manner. CHN induced DNA single‐strand breaks because alkaline comet parameters such as tail intensity, DNA in the tail, tail moment, and tail length increased. All CHN concentrations also significantly induced the formation of DNA double‐strand breaks (DSBs) because it increased phosphorylated H2AX protein foci for all treatment times and p53‐binding protein 1 foci for all treatments except for the lowest concentration (0.15 mM) of 120‐hr treatment. DNA damage caused by DNA DSBs was not repaired in a 24‐hr recovery period. CHN also induced oxidative stress by decreasing reduced glutathione and increasing lipid peroxidation. These results make it necessary to conduct studies about the detailed carcinogenic potential of CHN in humans because it can induce both oxidative and DNA damage.
A novel Internet of things‐based plug‐and‐play multigas sensor for environmental monitoring
Authors: Gomes João B. A. , Rodrigues Joel J. P. C. , Rabêlo Ricardo A. L. , Tanwar Sudeep , Al‐Muhtadi Jalal , Kozlov Sergey 
Published: April 2020

AbstractAmbient gas measurement is essential in diverse fields and applications, from preventing accidents, to air pollution warnings, and granting the correct gas mixture to patients in hospitals. Gas leakage can reach large proportions, affecting neighborhoods or even cities, causing enormous environmental impacts. The integration of gas sensors through the Internet of things (IoT) paradigm should ease the information collecting and sharing processes, granting better experiences to users, and avoiding major losses and expenses. With this integration, final users must be capable of operating these gadgets without previous technological knowledge, thus, the proposal of plug‐and‐play (PnP) sensors and actuators should be considered. This article proposes an IoT‐based solution for sensing environmental gases preceding a PnP approach, combining the hardware and software integrations for a better user experience. In this proposal, the PnP interface is defined, using the universal asynchronous receiver/transmitter protocol. The wireless communication is made through the IEEE 802.15.4 and IEEE 802.11 (Wi‐Fi) standards. The proposed sensor is capable of detecting smoke, oxygen, hydrogen, carbon monoxide, alcohol vapor, liquefied petroleum gas, benzene, ammonia, methane, and propane. The solution is integrated with a middleware for IoT, called In.IoT, a software that receives the sensed data, stores, and forward them to other smart devices on the same context, allowing an Android‐based mobile application to warn users regarding the environmental gases concentrations. The proposed solution is experimented, demonstrated, validated, and it is ready for use.
Optimal deep learning based image compression technique for data transmission on industrial Internet of things applications
Authors: Sujitha Ben , Parvathy Velmurugan Subbiah , Lydia E. Laxmi , Rani Poonam , Polkowski Zdzislaw , Shankar K. 
Published: April 2020

AbstractRecently, industrial Internet of things becomes more popular and it involves a group of intelligent devices linked to create systems which observe, gather, communicate, and investigate data. In this view, the demand for compression techniques in remote sensing images is increasing since low complexity technique is required in spacecraft. Deep learning, for instance, convolutional neural network (CNN) has gained more attention in the domain of computer vision, particularly for high‐level applications like detection along with interpretation. At the same time, it is difficult to resolve the low‐level applications like image compression and it is investigated in this article. This article presents an optimal compression technique using CNNs for remote sensing images. The proposed method uses CNN for learning the compact representation of the original image which held the structural data and was then coded by Lempel Ziv Markov chain algorithm. Next, the encoded image was reconstructed to retrieve the original image with high reconstructed image quality. The proposed optimal compression technique is compatible with the available image codec standards. Wide range of experiments was carried out and the results were compared with binary tree and optimized truncation, JPEG, and JPEG2000 in terms of compression efficiency, reconstructed image quality, and space saving (SS). The obtained results apparently proved the effectiveness of the presented method, which attains an average peak signal to noise ratio of 49.90 dB and SS of 89.38%.
Method for collecting data of children descending movement on stairs in schools
Authors: Ono Rosaria , Valentim Marcos Vargas , Vittorino Fulvio 
Published: April 2020

SummaryA method to collect the times and travel routes in predefined sections of stairs is presented, in order to obtain walking velocities of children. Twenty‐seven possible travel paths on landings and nine possible travel paths on flights are proposed and the equations developed to calculate them are presented. Experiments were carried out where data were not collected from fire drills, as usually are, but from the movement of unimpeded individuals descending stairs using this method. The technique used to collect data was the observation of video recordings via a closed‐circuit television system. Seven hundred and eighty‐three students ranging from 6 to 10 years of age and from three different schools participated in the experiments. Particularly, movements on stair flights and landings were analyzed separately for a group of 54 students of the first grade (6 years‐old), for a comparative analysis of the distances and velocities obtained with methods used by other researchers and significant differences were found. In addition, by the present method, the dispersion of velocity values in a population was studied; thus, the shape of its frequency distribution could be verified. An uncertainty estimative of the method is presented together with the discussion of its usage difficulties.
Review of the effects of vitexin in oxidative stress‐related diseases
Authors: Babaei Fatemeh , Moafizad Armita , Darvishvand Zahra , Mirzababaei Mohammadreza , Hosseinzadeh Hossein , Nassiri‐Asl Marjan 
Published: April 2020

AbstractVitexin is an apigenin flavone glycoside found in food and medicinal plants. It has a variety of pharmacological effects, including antioxidant, anti‐inflammatory, anticancer, antinociceptive, and neuroprotective effects. This review study summarizes all the protective effects of vitexin as an antioxidant against reactive oxygen species, lipid peroxidation, and other oxidative damages in a variety of oxidative stress‐related diseases, including seizure, memory impairment, cerebral ischemia, neurotoxicity, myocardial and respiratory injury, and metabolic dysfunction, with possible molecular and cellular mechanisms. This review describes any activation or inhibition of the signaling pathways that depend on the antioxidant activity of vitexin. More basic research is needed on the antioxidative effects of vitexin in vivo, and carrying out clinical trials for the treatment of oxidative stress‐related diseases is also recommended.
A randomized clinical trial of sildenafil plus clomiphene citrate to improve the success rate of ovulation induction in patients with unexplained infertility
Authors: Aboelroose Ahmed A. , Ibrahim Zakia M. , Madny Elham H. , Elmazzahy Ahmed M. , Taha Omima T. 
Published: April 2020

AbstractObjectivesTo investigate the role of sildenafil citrate in improving ovulation induction success rate in women with unexplained infertility.MethodsA randomized clinical trial from January to December 2018 of 80 women with unexplained infertility randomized into two groups. Both groups received 100 mg clomiphene citrate once daily from days 3–7 of the menstrual cycle. The study group also received 25 mg oral sildenafil citrate twice daily from days 8–12 of the same cycle. Transvaginal ultrasound assessed ovulation, endometrial thickness, and number of follicles. Pregnancy was assessed 2 weeks after ovulation. Primary outcome measures were endometrial thickness, number of mature follicles, and pregnancy rates.ResultsPregnancy rates (26 (65%) and 16 (40%), P=0.043) and endometrial thickness (10.4 ± 1.4 and 9.2 ± 1.9, P=0.007) were significantly higher in the study group. More women in the study group reported adverse effects compared with the control group (17 [42.5%] vs 9 [22.5%]; P=0.034), with headache the most common adverse effect in the study group, reported by 8 (20.0%) patients.ConclusionAdding sildenafil citrate improved ovulation success rate and increased pregnancy rate.Pan African Clinical Trial Registry: PACTR201907658492123
Comparing econometric methods to empirically evaluate activation programs for job seekers
Authors: Muller Paul , van der Klaauw Bas , Heyma Arjan 
Published: April 2020

SummaryWe test whether different identification strategies give similar results when evaluating activation programs. Budgetary problems at the Dutch unemployment insurance (UI) administration in March 2010 caused a sharp drop in the availability of these programs. Using administrative data provided by the UI administration, we evaluate the effect of the program (1) exploiting the policy discontinuity as a quasi‐experiment, (2) using dynamic matching assuming conditional independence, and (3) applying the timing‐of‐events model. All three strategies use the same data to consider the same program in the same setting, and show that the program reduces job finding directly after enrollment. However, the magnitude of the estimated drop in job finding differs between the three estimation methods. In the longer run, all three methods show a zero effect on employment.
Endogeneity and non‐response bias in treatment evaluation – nonparametric identification of causal effects by instruments
Authors: Fricke Hans , Frölich Markus , Huber Martin , Lechner Michael 
Published: April 2020

SummaryThis paper proposes a nonparametric method for evaluating treatment effects in the presence of both treatment endogeneity and attrition/non‐response bias, based on two instrumental variables. Using a discrete instrument for the treatment and an instrument with rich (in general continuous) support for non‐response/attrition, we identify the average treatment effect on compliers as well as the total population under the assumption of additive separability of observed and unobserved variables affecting the outcome. We suggest non‐ and semiparametric estimators and apply the latter to assess the treatment effect of gym training, which is instrumented by a randomized cash incentive paid out conditional on visiting the gym, on self‐assessed health among students at a Swiss university. The measurement of health is prone to non‐response, which is instrumented by a cash lottery for participating in the follow‐up survey.
Posterior reversible encephalopathy syndrome associated with Guillain‐Barré syndrome: Case report and clinical management considerations
Authors: Salvalaggio Alessandro , Cagnin Annachiara , Marson Piero , Ferracci Franco , Cortelli Pietro , Corbetta Maurizio , Briani Chiara 
Published: April 2020

AbstractAround half of the patients with Guillain‐Barré syndrome (GBS) present autonomic dysfunction requiring admission to intensive care unit in up to a quarter of patients. Treatment of GBS consists of plasma exchange (PE) and intravenous immunoglobulins (IVIG). Posterior reversible encephalopathy syndrome (PRES) consists in a reversible subcortical vasogenic brain edema caused by endothelial damage triggered by abrupt blood pressure changes. We report on a woman who presented with PRES in the course of GBS treated first with IVIG, and then with PE. The present report underlines the challenge that the clinicians face when these two rare syndromes concur. The literature is not helpful considering that both blood pressure fluctuations and IVIG are reported to be involved in the pathogenesis of PRES. In the present letter, both pathogenic mechanisms and clinical management considerations are discussed.
A consolidated model for telepsychology practice
Authors: McCord Carly , Bernhard Paula , Walsh McKay , Rosner Christine , Console Katie 
Published: April 2020

AbstractObjectiveIn this paper, we identify available telepsychology guidelines, understand similarities and differences, and organize the contents into a model of core practice domains pertinent to a variety of applications of telepsychology practice.MethodA scoping review of current telepsychology guidelines was conducted to identify, organize, and distill available telepsychology guidelines (Arksey & O'Malley, 2005, Int J Soc Res Methodol, 8, 19–32).ResultsWe identified overlap among five sets of telepsychology guidelines currently available and presented a consolidated model including nine practice domains influenced by practice setting and modality.ConclusionsTelepsychology has the potential to address current issues in availability, accessibility, acceptability, anonymity, and affordability of mental health services but establishing or engaging in telepsychology practice has been daunting for many practitioners. Telepsychologists can disseminate applications of this model in different settings and with different modalities and this practice model can inform future development of competencies.
Speaking power to power: Grassroots democracy in the anti‐fracking movement in Bulgaria
Authors: Mihaylov Nikolay L. 
Published: April 2020

AbstractThe anti‐fracking movement (AFM) in Bulgaria, was a successful grassroots local‐to‐national organizing effort to change public policy. The study draws on social movements, community psychology, and grassroots democracy theory to explore, describe and critique how participants in the AFM collectively constructed meanings and practices of organizing in interaction with the sociopolitical context as they expanded their efforts from the local to the national level of policy‐making. Data for the study were collected from semi‐structured interviews with activists, movement documents, and participant observations. Structured and open coding followed by qualitative analyses produced descriptions and explanations of grassroots democracy in the movement. The movement was based on a prefigurative vision and practice of an antihierarchical “civic society” and was also shaped by the demands of the Bulgarian political context. Power, consent, and participation had dynamic meanings and forms that secured both grassroots democracy and effective political action. Тhe AFM resisted well‐known mechanisms of hierarchization and co‐optation, but it also reproduced certain inequalities of power. The findings relate to recent trends for expansion of community organizing to the national level of politics, for expansion of the community organizing models outside the United States, and for a popular grassroots preference for anti‐organizational organizing.
Thiophene derivatives: A potent multitargeted pharmacological scaffold
Authors: Singh Atamjit , Singh Gurvinder , Bedi Preet Mohinder Singh 
Published: April 2020

AbstractDespite a significant work that has been done on thiophene, continuous efforts are still being made by the researchers to identify novel heterocyclic compounds with potential bioactivities. Thiophene nucleus has been extensively utilized by the researchers across the globe for the development of diverse bioactive heterocycles for hitting a wide range of biological targets. This review throws light on synthetic approaches that have been used for the synthesis of potential thiophene derivatives followed by the depth analysis of them with respect to their pharmacological significance. This review can help the medicinal chemists and researchers to develop novel leads having thiophene nucleus with high efficacy and reduced side effects.
Metabolic profiling of different wild and cultivated Allium species based on high‐resolution mass spectrometry, high‐performance liquid chromatography‐photodiode array detector, and color analysis
Authors: Maccelli Alessandro , Cesa Stefania , Cairone Francesco , Secci Daniela , Menghini Luigi , Chiavarino Barbara , Fornarini Simonetta , Crestoni Maria Elisa , Locatelli Marcello 
Published: April 2020

AbstractMany plants of the genus Allium are widely cultivated and consumed for their nutraceutical and health‐enhancing bioactive components effective in many metabolic and infectious diseases. In particular, Allium sativum L. (garlic), the most economically important Allium species, is known to present volatile, comparatively polar sulfur‐containing compounds responsible for both the typical garlic aroma and antimicrobial property. More recently, the (moderately) polar portion of garlic metabolome, rich of polyphenols and amino acids, is gaining increasing interest as a source of antioxidants and primary nutrients. In this study, we have explored the chemical diversity of eight different hydroalcoholic extracts obtained by microwave‐assisted extraction of white and red crop A. sativum and wild Allium triquetrum, Allium roseum, and Allium ampeloprasum, all originating from the Mediterranean Basin. The aim is to appraise their potential dietetic and healing value through an in‐depth chemical characterization and contribute to preserve and exploit natural resources. The multimethodological method applied here is based on an untargeted metabolic profiling by means of high‐resolution electrospray ionization Fourier‐transform ion cyclotron resonance (ESI FT‐ICR) mass spectrometry. More than 850 by ESI(+) and 450 by ESI(−) putative metabolites have been annotated covering all main classes of primary and secondary metabolites, including amino acids, alkaloids, organic and fatty acids, nucleotides, vitamins, organosulfur compounds, and flavonoids. The pigment and polyphenol components have been separated and quantified by a targeted chromatographic high‐performance liquid chromatography‐photodiode array detector (HPLC‐PDA) and CIEL*a*b* colorimetric assay, showing characteristic yellow and red components in each extract, related to a different milieu of anthocyanins and flavonoids as assigned by high‐resolution mass spectrometry (MS).
Modeling long‐term salt marsh response to sea level rise in the sediment‐deficient Plum Island Estuary, MA
Authors: Langston Amy K. , Durán Vinent Orencio , Herbert Ellen R. , Kirwan Matthew L. 
Published: April 2020

AbstractAn accelerating global rate of sea level rise (SLR), coupled with direct human impacts to coastal watersheds and shorelines, threatens the continued survival of salt marshes. We developed a new landscape‐scale numerical model of salt marsh evolution and applied it to marshes in the Plum Island Estuary (Massachusetts, U.S.A.), a sediment‐deficient system bounded by steep uplands. To capture complexities of vertical accretion across the marsh platform, we employed a novel approach that incorporates spatially variable suspended sediment concentrations and biomass of multiple plant species as functions of elevation and distance from sediment sources. The model predicts a stable areal extent of Plum Island marshes for a variety of SLR scenarios through 2100, where limited marsh drowning is compensated by limited marsh migration into adjacent uplands. Nevertheless, the model predicts widespread conversion of high marsh vegetation to low marsh vegetation, and accretion deficits that indicate eventual marsh drowning. Although sediment‐deficient marshes bounded by steep uplands are considered extremely vulnerable to SLR, our results highlight that marshes with high elevation capital can maintain their areal extent for decades to centuries even under conditions in which they will inevitably drown.
A Randomized, Split‐Face, Double‐Blind Comparison Trial Between Fractionated Frequency‐Doubled 1064/532 nm Picosecond Nd:YAG Laser and Fractionated 1927 nm Thulium Fiber Laser for Facial Photorejuvenation
Authors: Wu Douglas C. , Jones Isabela T. , Boen Monica , Al‐Haddad Marwan , Goldman Mitchel P. 
Published: April 2020

Background and ObjectiveFractionated lasers are a popular therapeutic option for facial photorejuvenation. In this study, we compare the safety, tolerability, and efficacy of a fractionated frequency‐doubled 1064/532 nm picosecond Nd:YAG fractionated picosecond laser (FPL) versus a fractionated 1927 nm thulium fiber laser (TFL) for facial rejuvenation.Study Design/Materials and MethodsThis was a double‐blind, randomized, split‐face comparison study involving 20 subjects. Facial halves were randomized to receive either FPL or TFL treatment. Three treatments were delivered at 1‐month intervals. Subjects were followed up for 1, 3, and 6 months post‐final treatment session and evaluated by blinded, non‐treating investigators for dyspigmentation, erythema, keratosis, texture, and rhytids on a standardized scale. Subjects also recorded a quantitative daily diary rating healing progress for 14 days after every treatment session.ResultsStatistically significant improvements in elastosis, erythema, keratosis, dyschromia, and skin texture were noted in both treatment groups. There were no significant differences detected in clinical efficacy between the two groups. Subject daily dairies revealed statistically significant differences in tolerability during the immediate 14‐day post‐operative recovery period. The facial half treated with FPL displayed significantly less redness on days 3 and 4; significantly less swelling on day 5; significantly less crusting on days 1 through 9; significantly less peeling on days 3 through 9; and significantly less itch on days 4 and 7. There were no unexpected adverse effects observed.ConclusionBoth FPL and TFL are safe and effective treatment options for facial rejuvenation. FPL may be associated with significantly less downtime. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.