bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge-sharing restrictions in the life sciences: personal and context-specific factors in academia–industry knowledge transfer
Authors: Gerbin Ani , Drnovsek Mateja 
Published: July 2020

PurposeKnowledge sharing in research communities has been considered indispensable to progress in science. The aim of this paper is to analyze the mechanisms restricting knowledge sharing in science. It considers three categories of academia–industry knowledge transfer and a range of individual and contextual variables as possible predictors of knowledge-sharing restrictions.Design/methodology/approachA unique empirical data sample was collected based on a survey among 212 life science researchers affiliated with universities and other non-profit research institutions. A rich descriptive analysis was followed by binominal regression analysis, including relevant checks for the robustness of the results.FindingsResearchers in academia who actively collaborate with industry are more likely to omit relevant content from publications in co-authorship with other academic researchers; delay their co-authored publications, exclude relevant content during public presentations; and deny requests for access to their unpublished and published knowledge.Practical implicationsThis study informs policymakers that different types of knowledge-sharing restrictions are predicted by different individual and contextual factors, which suggests that policies concerning academia–industry knowledge and technology transfer should be tailored to contextual specificities.Originality/valueThis study contributes new predictors of knowledge-sharing restrictions to the literature on academia–industry interactions, including outcome expectations, trust and sharing climate. This study augments the knowledge management literature by separately considering the roles of various academic knowledge-transfer activities in instigating different types of knowledge-sharing restrictions in scientific research.
Nurturing customer service culture in an experience economy: employees' assessment of the UWI, Mona Library service model
Authors: Harris Sasekea , Folkes Cheryl , Tyrell Karen , Brown David 
Published: July 2020

PurposeIn an experience economy, the alternative options for higher education are varied; resulting in competition and a deliberate focus on student experience to create competitive advantage. In this regard, the various constituents of the university, including the library, are required to transform the organisational culture, specifically, the service culture, to engage students in a way that creates a memorable experience. In response, The UWI, Mona Library re-launched its Customer Service programme: using an in-house inspired 10 element service model, with initiatives aimed at realising each element, the library purposed to build a service culture. This paper seeks to assess employees' perception of the impact of the initiatives of this model.Design/methodology/approachThis survey research employed individual interviews to assess employees' perception of the impact of the initiatives of the service model, with the objective of refining the model, where needed, for continued use in the Mona Library, and for use in libraries desirous of implementing the model.FindingsThe initiatives of the service model are creating the desired customer service culture and aspects have been identified for refinement.Research limitations/implicationsThe model is based on the needs, experiences, history, culture and strategic priorities of one Caribbean university library. It centres on the employees and their perception. As such, it focuses less on the product, space and the external customer; but it is hoped that by focusing on the employees (specifically creating a service culture amongst them) that this will ultimately impact product, space and the overall customer experience.Practical implicationsProvides the top priorities and considerations for a practicing Caribbean / developing country academic library manger, with an interest in a model for nurturing service culture amongst the employees.Originality/valueThis paper is of value as it centres on creating a service culture, rather than on the usual customer service satisfaction survey, offers a service model and adds to the literature on customer service in academic libraries.
The effect of information privacy concern on users' social shopping intention
Authors: Zhou Tao 
Published: July 2020

PurposeThe purpose of this research is to examine the effect of information privacy concern on users' social shopping intention.Design/methodology/approachBased on the 340 valid responses collected from a survey, structural equation modeling (SEM) was employed to examine the research model.FindingsThe results indicated that while disposition to privacy positively affects privacy concern, both reputation and laws negatively affect privacy concern, which in turn decreases social shopping intention. In addition, trust partially mediates the effect of privacy concern on social shopping intention.Research limitations/implicationsThe results imply that social commerce companies need to mitigate users' privacy concern in order to facilitate their shopping behavior.Originality/valueThis research disclosed that privacy concern receives a tripartite influence from users (disposition to privacy), platforms (reputation) and governments (laws). The results help us gain a complete understanding of information privacy concern mitigation in social shopping.
Disparities in perceived disciplinary knowledge among new doctoral students
Authors: Flaster Allyson , Glasener Kristen M. , Gonzalez John A. 
Published: July 2020

PurposeThe purpose of this study is to examine whether there are differences in beginning doctoral students’ perceptions of the disciplinary knowledge required to be successful in doctoral education and identify pre-doctoral characteristics and experiences that explain these differences.Design/methodology/approachThis study relied on survey data of first-year PhD students enrolled at a large, research-intensive university. Survey responses were matched to institutional information, missing data were imputed and responses were weighted to account for groups’ differential probabilities of being included in the analytical sample. The authors used regression analysis to examine the relationship between students’ background characteristics, anticipatory socialization experiences, academic performance and perceived levels of disciplinary knowledge.FindingsThe study findings indicated significant differences in doctoral students’ perceived levels of disciplinary knowledge. Students who identify as female or URM had significantly lower levels of perceived disciplinary knowledge than students who identify as male or non-URM. Moreover, several anticipatory socialization experiences were significantly and positively related to perceived disciplinary knowledge.Originality/valueWhile there is evidence that doctoral students start graduate school with varying identities and experiences, little is known about how students perceive their abilities and knowledge. This study reported that students differ in their self-assessment of disciplinary knowledge as they embark on doctoral work with implications for academic identity development and student success.
Domestic growth based on international acquisition – a case study of Fosun tourism group
Authors: Zhao Kuan , Zhang Shuai 
Published: July 2020

Purpose
In recent years, with the steady growth of China’s economy and world’s vacation market, and powered by the growing and significant large demands of Chinese overseas travel, an emergent trend of international development by major Chinese tourism groups has attracted notice by scholars and practitioners and this is obvious especially in the private sector. With this as the background, this paper aims to explore how China’s leading tourism companies expand their business internationally through a case study approach.
Two‐year outcomes following naloxone administration by police officers or emergency medical services personnel
Authors: Lowder Evan M. , Lawson Spencer G. , O'Donnell Daniel , Sightes Emily , Ray Bradley R. 
Published: July 2020

Research SummaryWe conducted a retrospective, quasi‐experimental study of a police naloxone program to examine individual outcomes following nonfatal overdose where either police (n = 111) or emergency medical services (n = 1,229) provided a first response and administered naloxone. Individuals who received a police response were more likely to be arrested immediately following initial dispatch and had more instances of repeat nonfatal overdose two years following dispatch; there were no differences in rearrest or death rates. Findings suggest police naloxone programs may increase short‐term incarceration risk, but we found little evidence overall of long‐term adverse effects.Policy ImplicationsNaloxone is a tool to reduce fatal opioid‐involved overdose. Its provision alone does not constitute a comprehensive agency response to the opioid epidemic. Findings support the need for standardized policies and procedures to guide emergency responses to nonfatal overdose events and ensure consistency across agencies.
Subsurface carbon monoxide oxidation capacity revealed through genome‐resolved metagenomics of a carboxydotroph
Authors: Mu Andre , Thomas Brian C. , Banfield Jillian F. , Moreau John W. 
Published: July 2020

SummaryMicrobial communities play important roles in the biogeochemical cycling of carbon in the Earth's deep subsurface. Previously, we demonstrated changes to the microbial community structure of a deep aquifer (1.4 km) receiving 150 tons of injected supercritical CO2 (scCO2) in a geosequestration experiment. The observed changes support a key role in the aquifer microbiome for the thermophilic CO‐utilizing anaerobe Carboxydocella, which decreased in relative abundance post‐scCO2 injection. Here, we present results from more detailed metagenomic profiling of this experiment, with genome resolution of the native carboxydotrophic Carboxydocella. We demonstrate a switch in CO‐oxidation potential by Carboxydocella through analysis of its carbon monoxide dehydrogenase (CODH) gene before and after the geosequestration experiment. We discuss the potential impacts of scCO2 on subsurface flow of carbon and electrons from oxidation of the metabolic intermediate carbon monoxide (CO).
Myosin heavy chains in extraocular muscle fibres: Distribution, regulation and function
Authors: Hoh Joseph F. Y. 
Published: July 2020

AbstractThis review examines kinetic properties and distribution of the 11 isoforms of myosin heavy chain (MyHC) expressed in extraocular muscle (EOM) fibre types and the regulation and function of these MyHCs. Although recruitment and discharge characteristics of ocular motoneurons during fixation and eye movements are well documented, work directly linking these properties with motor unit contractile speed and MyHC composition is lacking. Recruitment of motor units according to Henneman's size principle has some support in EOMs but needs consolidation. Both neurogenic and myogenic mechanisms regulate MyHC expression as in other muscle allotypes. Developmentally, multiply‐innervated (MIFs) and singly‐innervated fibres (SIFs) are derived presumably from distinct myoblast lineages, ending up expressing MyHCs in the slow and fast ends of the kinetic spectrum respectively. They modulate the synaptic inputs of their motoneurons through different retrogradely transported neurotrophins, thereby specifying their tonic and phasic impulse patterns. Immunohistochemical analyses of EOMs regenerating in situ and in limb muscle beds suggest that the very impulse patterns driving various ocular movements equip effectors with appropriate MyHC compositions and speeds to accomplish their tasks. These experiments also suggest that satellite cells of SIFs and MIFs are distinct lineages expressing different MyHCs during regeneration. MyHC compositions and functional characteristics of orbital fibres show longitudinal variations that facilitate linear ocular rotation during saccades. Palisade endings on global MIFs are postulated to respond to active and passive tensions by triggering axon reflexes that play important roles during fixation, saccades and vergence. How EOMs implement Listings law during ocular rotation is discussed.
Voriconazole therapeutic drug monitoring in critically ill patients improves efficacy and safety of antifungal therapy
Authors: Li Hao , Li Mo , Yan Jinqi , Gao Lan , Zhou Linjing , Wang Yang , Li Qi , Wang Jin , Chen Tianjun , Wang Taotao , Zheng Jie , Qiang Wei , Zhang Yongjian , Shi Qindong 
Published: July 2020

AbstractSince voriconazole plasma trough concentration (VPC) is related to its efficacy and adverse events, therapeutic drug monitoring (TDM) is recommended to perform. However, there is no report about the data of voriconazole TDM in critically ill patients in China. This retrospective study was performed to determine whether voriconazole TDM was associated with treatment response and/or voriconazole adverse events in critically ill patients, and to identify the potential risk factors associated with VPC. A total of 216 critically ill patients were included. Patients were divided into two groups: those underwent voriconazole TDM (TDM group, n = 125) or did not undergo TDM (non‐TDM group, n = 91). The clinical response and adverse events were recorded and compared. Furthermore, in TDM group, multivariate logistic regression analysis was performed to identify the possible risk factors resulting in the variability in initial VPC. The complete response in the TDM group was significantly higher than that in the non‐TDM group (P = .012). The incidence of adverse events strongly associated with voriconazole in the non‐TDM group was significantly higher than that in the TDM group (19.8% vs 9.6%; P = .033). The factors, including age (OR 0.934, 95% CI: 0.906‐0.964), male (OR 5.929, 95% CI: 1.524‐23.062), serum albumin level (OR 1.122, 95% CI: 1.020‐1.234), diarrhoea (OR 4.953, 95% CI: 1.495‐16.411) and non‐intravenous administration (OR 4.763, 95% CI: 1.576‐14.39), exerted the greatest effects on subtherapeutic VPC (VPC < 1.5 mg/L) in multivariate analysis. Intravenous administration (OR 7.657, 95% CI: 1.957‐29.968) was a significant predictor of supratherapeutic VPC (VPC > 4.0 mg/L). TDM can result in a favourable clinical efficacy and a lower incidence of adverse events strongly associated with voriconazole in critically ill patients. Subtherapeutic VPC was closely related to younger age, male, hyperalbuminaemia, diarrhoea and non‐intravenous administration, and intravenous administration was a significant predictor of supratherapeutic VPC.
Impact of timing of the anorexigen sibutramine administration on reproductive end‐points of male rats
Authors: Borges Cibele S. , Silva Patrícia V. , Lozano Ana Flávia Q. , Missassi Gabriela , Silva Raquel F. , Anselmo‐Franci Janete A. , Kempinas Wilma G. 
Published: July 2020

AbstractSibutramine is a non‐selective serotonin‐norepinephrine reuptake inhibitor orally administered for weight loss. In a previous study, we showed pharmacological mechanisms involved in the reduction of sperm quality and fertility of rats exposed for 30 days to this anorexigen in the light phase of the light‐dark (l/d) cycle. It is already known that rodents are nightlife animals, with higher metabolic activity during the dark phase than in the light phase of the light‐dark (l/d) cycle. Thus, the present study aimed to investigate whether the deleterious effects on reproductive parameters after sibutramine administration would be enhanced after a shorter period of exposure during the dark phase of the l/d cycle. For this, adult male Wistar rats were treated with sibutramine (10 mg/kg/d) or vehicle for 15 days during the dark phase of the l/d cycle. Sibutramine treatment decreased final body and reproductive organ weights, as well as serum testosterone levels. Sperm transit time through the epididymis was accelerated, and sperm concentration and motility were diminished in the sibutramine‐exposed rats. The decrease in sperm concentration was also verified in the epididymal histological sections. In conclusion, the deleterious effects of sibutramine on reproductive parameters of male rats were enhanced when the exposure occurred in the dark phase of the l/d cycle, even after a short exposure duration. Our results reinforce the impact of timing on drug therapeutic action.
5‐Fluorouracil‐treated planarians, a versatile model system for studying stem cell heterogeneity and tissue aging
Authors: Gambino Gaetana , Ippolito Chiara , Modeo Letizia , Salvetti Alessandra , Rossi Leonardo 
Published: July 2020

Background InformationPlanarians are a sound, well‐established model system for molecular studies in the field of stem cells, cell differentiation, developmental biology and translational research. Treated stem cell‐less planarians produced by X‐ray treatment are commonly used to study stem cell transcriptional profile and their role in planarian biological processes. X‐ray induces oxidative and DNA damage to differentiated cells, requires expensive radiation machines that are not available in most of the research centres and demand rigorous risk management and dedicated staff.ResultsWe tested the use of the well‐known antimetabolite genotoxic drug 5‐fluorouracil which mainly affects proliferating cells in way to demonstrate its use in replacing X‐ray treatment. We succeeded in demonstrating ability of high doses of 5‐fluorouracil to deplete Dugesia japonica stem cells and in identifying a 5‐fluorouracil transiently resistant population of lineage committed stem cells.Conclusions and SignificanceOur results encourage the use of 5‐fluorouracil‐treated planarians as a model system for studying mechanisms of resistance to genotoxicants, planarian stem cell heterogeneity and molecular cascades of tissue aging.
lncRNA IGKJ2‐MALLP2 suppresses LSCC proliferation, migration, invasion, and angiogenesis by sponging miR‐1911‐3p/p21
Authors: Cao Jing , Yang Zhenming , An Ran , Zhang Jiarui , Zhao Rui , Li Wenjing , Xu Licheng , Sun Yanan , Liu Ming , Tian Linli 
Published: July 2020

AbstractBecause advanced laryngeal squamous cell carcinoma (LSCC) is diagnosed as a malignant tumor with a poor prognosis, the associated mechanisms still need to be further investigated. As key players in the development and progression of LSCC, lncRNAs have attracted increasing attention from many researchers. In this study, a novel lncRNA termed IGKJ2‐MALLP2 was identified and investigated for its effects on the development of LSCC. IGKJ2‐MALLP2 expression was confirmed by RT‐qPCR in 78 pairs of tissues and human laryngeal carcinoma cell lines. The results of this study showed that the expression of IGKJ2‐MALLP2 was reduced in LSCC tissues and displayed close relationships with tumor stage, lymph node metastasis, and clinical stage. Using a dual‐luciferase reporter assay, the ability of miR‐1911‐3p to bind both IGKJ2‐MALLP2 and p21 mRNA was demonstrated. IGKJ2‐MALLP2 could upregulate p21 expression by competitively binding miR‐1911‐3p. Moreover, IGKJ2‐MALLP2 effectively hindered the invasion, migration, and proliferation of AMC‐HN‐8 and TU212 tumor cells. Furthermore, its high expression could hinder the secretion of VEGF‐A and suppress angiogenesis. As revealed by the results of in vitro experiments, IGKJ2‐MALLP2 overexpression could restrict tumor growth and blood vessel formation in a xenograft model of LSCC. As indicated from the mentioned findings, IGKJ2‐MALLP2, which mediates p21 expression by targeting miR‐1911‐3p, was capable of regulating LSCC progression and could act as an underlying therapeutic candidate to treat LSCC.
Tackling reporting issues and variation in behavioural weight management interventions: Design and piloting of the standardized reporting of adult behavioural weight management interventions to aid evaluation (STAR‐LITE) template
Authors: Heggie Lisa , Mackenzie Ruth M. , Ells Louisa J. , Simpson Sharon Anne , Logue Jennifer 
Published: July 2020

SummaryIn the United Kingdom, the National Institute for Health and Care Excellence make recommendations to guide the local‐level selection and implementation of adult behavioural weight management interventions (BWMIs) which lack specificity. The reporting of BWMIs is generally poorly detailed, resulting in difficulties when comparing effectiveness, quality and appropriateness for participants. This non‐standardized reporting makes meta‐analysis of intervention data impossible, resulting in vague guidance based on weak evidence, reinforcing the urgent need for consistency and detail within BWMI description. STAR‐LITE ‐ a 4‐section, 119‐item standardized adult BWMI reporting template ‐ was developed and tested using a two‐phase process. After initial design, the template was piloted using adult behavioural weight management RCTs and currently implemented UK BWMI mapping information to further refine the template and examine current reporting and variance. Overall, reporting quality of weight management RCTs was poor, and large variance across different components of real‐world BWMIs was observed. Non‐specific guidance and wide variation in adult BWMIs are likely linked to inadequate RCT reporting quality and the inability to perform reliable comparisons of data. Future use of STAR‐LITE would facilitate the consistent, detailed reporting of adult BWMIs, supporting their evaluation and comparison, to ultimately inform effective policy and improve weight management practice.
Management and tolerability of glecaprevir‐pibrentasvir pharmacotherapy in hepatitis C viremic heart and lung transplant recipients
Authors: Lewis Tyler C. , Gidea Claudia , Reyentovich Alex , Angel Luis , Lesko Melissa , Pavone Jennifer , Sureau Kimberly , Smith Deane E. , Kon Zachary , Moazami Nader 
Published: July 2020

AbstractWe conducted a retrospective review of thoracic transplant recipients (22 heart and 16 lung transplant recipients) prospectively enrolled in a single‐center observational study of HCV NAT+ organ transplantation in HCV NAT− recipients. All recipients were treated with 8 weeks of glecaprevir‐pibrentasvir (GP) for HCV viremia in addition to standard triple immunosuppression post‐transplant. Thoracic transplant recipients of HCV NAT− organs were used as a control (24 heart and 22 lung transplant recipients). Our primary outcome was to assess the effect of GP on tacrolimus dose requirements. Secondary objectives included assessing drug interactions with common post‐transplant medications, adverse effects, and the need to hold or discontinue GP therapy. The median tacrolimus concentration‐to‐dose ratio (CDR) in the cohort was 184 (99‐260) during GP therapy and 154 (78‐304) over the first month after GP (P = .79). Trends in median tacrolimus CDR were similar on a per‐week basis and per‐patient basis. In three instances, concomitant posaconazole and GP led to hyperbilirubinemia and interruption of posaconazole. GP therapy was held in one heart transplant recipient and discontinued in another due to unresolving hyperbilirubinemia. Utilization of GP to treat HCV viremia post–thoracic transplant is feasible and safe, but requires modifications to post‐transplant pharmacotherapy and careful monitoring for adverse effects.