bluuebunny/crossref_metadata_2025_split huggingface dataset:
The engagement of stakeholders in nonfinancial reporting: New information‐pressure, stimuli, inertia, under short‐termism in the banking industry
Authors: Campra Maura , Esposito Paolo , Lombardi Rosa 
Published: January 2020

AbstractIn the past few years, nonfinancial reporting has been a widely debated issue in literature, not the least because of its importance during times in which topics such as climate change and social transformations have become strategic issues particularly for larger companies. Recent regulatory changes within the European legal framework have marked the transition from a voluntary nonfinancial reporting system to a mandatory one for larger companies. Unlike the case of manufacturing companies, the debate surrounding the application of CSR policies in the banking industry has not been as univocal. Taking into account a case study, we how such pressure is neither strictly positive nor negative, but it can rather be defined as a stimulating inertia, able to indicate prompt and sure strategic directions for the Company, to be pursued in a sustainable manner. This will need the implementation of internationally acknowledged policies and procedures regulating the interactions between the Company and its stakeholders.
Deep sequencing of myxoinflammatory fibroblastic sarcoma
Authors: Arbajian Elsa , Hofvander Jakob , Magnusson Linda , Mertens Fredrik 
Published: January 2020

AbstractMyxoinflammatory fibroblastic sarcoma (MIFS) has recurrent genetic features in the form of a translocation t(1;10)(p22‐31;q24‐25),BRAFgene fusions, and/or an amplicon in 3p11‐12 including theVGLL3gene. The breakpoints on chromosomes 1 and 10 in the t(1;10) cluster in or near theTGFBR3andOGAgenes, respectively. We here used a combination of deep sequencing of the genome (WGS), captured sequences (Cap‐seq), and transcriptome (RNA‐seq) and genomic arrays to investigate the molecular outcome of the t(1;10) and theVGLL3amplicon, as well as to assess the spectrum of other recurrent genomic features in MIFS. Apart from aROBO1‐BRAFchimera in a t(1;10)‐negative MIFS‐like tumor, no fusion gene was found at RNA‐seq. This was in line with WGS and Cap‐seq results, revealing variable breakpoints in chromosomes 1 and 10 and genomic breakpoints that should not yield functional fusion transcripts. The most common genomic rearrangements were breakpoints in or around theOGA,NPM3, andFGF8genes in chromosome band 10q24, and loss of 1p11‐p21 and 10q26‐qter (all simultaneously present in 6/7 MIFS); a breakpoint in or nearTGFBR3in chromosome 1 was found in four of these tumors. Amplification and overexpression ofVGLL3was a consistent feature in MIFS and MIFS‐like tumors with amplicons in 3p11‐12. The significant molecular genetic outcome of the recurrent t(1;10) could be loss of genetic material from 1p and 10q. Other recurrent genomic imbalances in MIFS, such as homozygous loss ofCDKN2Aand 3p‐ and 13q‐deletions, are shared with other sarcomas, suggesting overlapping pathogenetic pathways.
Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient‐Derived Xenograft Assays
Authors: Zhu Min , Li Lin , Lu Tianshi , Yoo Hyesun , Zhu Ji , Gopal Purva , Wang Sam C. , Porembka Matthew R. , Rich Nicole E. , Kagan Sofia , Odewole Mobolaji , Renteria Veronica , Waljee Akbar K. , Wang Tao , Singal Amit G. , Yopp Adam C. , Zhu Hao 
Published: January 2020

Background and Aims
Several major factors limit our understanding of hepatocellular carcinoma (HCC). First, human HCCs are infrequently biopsied for diagnosis and thus are not often biologically interrogated. Second, HCC initiation and progression are strongly influenced by the cirrhotic microenvironment, and the exact contributions of intrinsic and extrinsic tumor factors are unclear. A powerful approach to examine the personalized biology of liver cancers and the influence of host tissues is with patient‐derived xenograft (PDX) models. In Asia, HCCs from patients with hepatitis B virus have been efficiently converted into PDXs, but few parallel efforts from the west have been reported.

Approach and Results
In a large‐scale analysis, we implanted 93 HCCs and 8 cholangiocarcinomas (CCAs) to systematically analyze host factors and to define an optimized platform for PDX development from both surgical and biopsy samples. NOD Scid IL‐2Rγ−/−
(NSG) mice that had undergone partial hepatectomy (PHx) represented the best combination of engraftability, growth, and passageability, but overall rates were low and indicative of a unique intrinsic biology for HCCs in the United States. PDX models preserved the histology and genetic features of parental tumors, and ultimately, eight models were usable for preclinical studies. Intriguingly, HCC PDXs were differentially sensitive to regorafenib and sorafenib, and CCA PDXs were also highly sensitive to regorafenib.

Conclusions
PDX models functionalize early and advanced stage HCCs and revealed unique biological features of liver cancers from the United States.
Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
Authors: Duan Zhi‐xi , Tu Chao , Liu Qing , Li Shuang‐qing , Li Yi‐han , Xie Peng , Li Zhi‐hong 
Published: January 2020

AbstractCartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of AdipoRon, an adiponectin receptor agonist, on the chondrocytes calcification. Primary chondrocytes were isolated and cultured from normal cartilage and OA cartilage. The calcification in tissues was evaluated by inductively coupled plasma/atomic emission spectroscopy and alizarin red S staining. The calcification in chondrocytes was determined using the alkaline phosphatase (ALP) staining and an ALP assay kit. The cellular effects of AdipoRon were assessed by immunofluorescence staining and Western blot analysis. We found that calcification was significantly increased in OA cartilage tissues and cells. Importantly, the degree of calcification and ALP activity of the OA chondrocytes was decreased upon the treatment with AdipoRon. The AdipoRon‐induced cellular effects, including the reduction of the calcification of chondrocytes and improvement of autophagy, were blocked by dorsomorphin, an 5′‐adenosine monophosphate‐activated protein kinase (AMPK) inhibitor. Moreover, autophagy activation by AdipoRon was mediated by the AMPK‐mammalian target of rapamycin (mTOR) signaling pathway. Our results suggest that AdipoRon significantly alleviates the calcification of OA chondrocytes via activating AMPK‐mTOR signaling to promote autophagy. Therefore, AdipoRon could be a potential therapeutic agent for the prevention and treatment of OA.
Serum exosomal miR‐7977 as a novel biomarker for lung adenocarcinoma
Authors: Chen Liangyuan , Cao Pengju , Huang Chunli , Wu Qiumei , Chen Shaoting , Chen Falin 
Published: January 2020

AbstractExosomal microRNAs (miRNAs) have great potentials as a novel biomarker to predict lung cancer. We applied a miRNA microarray to identify aberrantly expressed serum exosomal miRNAs as candidate biomarkers for patients with lung adenocarcinoma (LUAD). Compared with the normal control, 31 exosomal miRNAs were found to be upregulated and 29 exosomal miRNAs were downregulated in the serum of LUAD respectively. Then, 10 dysregulated exosomal miRNAs expression levels in serum were further validated via qRT‐polymerase chain reaction. Notably, exosomal miR‐7977 was highest expressed and miR‐98‐3p was lowest expressed in the patients with LUAD, and exosomal miR‐7977 showed significant correlation with the N stage and TNM stage with patients with LUAD (P < .05). Receiver operating characteristic curve showed that the abundant level of exosomal miR‐7977 may predict LUAD with an area of under the curve (AUC) of 0.787. In comparison with exosomal miR‐7977, exosomal miR‐98‐3p had a smaller area (0.719). The combination of exosomal miR‐7977 and miR‐98‐3p improved the AUC to 0.816. Furthermore, in vitro experiments revealed that inhibition of miR‐7977 enhanced the proliferation, invasion, and inhibited apoptosis in A549 cells, the opposite results were performed by miR‐7977 mimics. In conclusion, exosomal miR‐7977 was identified as a novel biomarker for patients with LUAD and may play as a tumor suppressor in lung cancer.
The exploration of new therapeutic targets for HPV‐negative head and neck squamous cell cancer through the construction of a ceRNA network and immune microenvironment analysis
Authors: Wang Zuoyuan , Liu Tianyi , Li Guangqi , Cao Zhipeng 
Published: January 2020

AbstractPrevious studies have shown that human papillomavirus (HPV)‐negative patients with head and neck squamous cell cancer (HNSCC) suffer from an unsatisfactory prognosis. Long noncoding RNAs (lncRNAs) have been verified to participate in many biological processes, including regulating gene expression as competing endogenous RNAs (ceRNAs), while few studies focused the ceRNA network regulation mechanism in patients with HPV‐negative HNSCC tumor. Meanwhile, the immune microenvironment may be critical in the development and prognosis of HPV‐negative tumors. Our study aimed to further investigate the pathogenesis and potential biomarkers for the diagnosis, therapy and prognosis of HPV‐negative HNSCC through a ceRNA network. Comprehensively analyzing the sequencing data of lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) in The Cancer Genome Atlas HNSCC dataset, we constructed a differentially expressed ceRNA network containing 131 lncRNAs, 35 miRNAs and 162 mRNAs. Then, survival analysis in the network was cited to explore the prognostic biomarkers. Eight mRNAs, nine lncRNAs, and one miRNA were identified to be associated with prognosis. Neuropilin (NRP) binding function, retinoid X receptor (RXR) binding, and the vascular endothelial growth factor (VEGF) signaling pathway were associated with the enrichment analysis, and they also related to the immune microenvironment. Combined with the analysis of the immune microenvironment differences, we obtained new targeted therapies using an RXR agonist, or a combination of the VEGF monoclonal antibody and an NRP antagonist, which may provide a promising future for HPV‐negative HNSCC patients.
Infrared and Raman spectra of lignin substructures: Dibenzodioxocin
Authors: Bock Peter , Nousiainen Paula , Elder Thomas , Blaukopf Markus , Amer Hassan , Zirbs Ronald , Potthast Antje , Gierlinger Notburga 
Published: January 2020

AbstractVibrational spectroscopy is a very suitable tool for investigating the plant cell wall in situ with almost no sample preparation. The structural information of all different constituents is contained in a single spectrum. Interpretation therefore heavily relies on reference spectra and understanding of the vibrational behavior of the components under study. For the first time, we show infrared (IR) and Raman spectra of dibenzodioxocin (DBDO), an important lignin substructure. A detailed vibrational assignment of the molecule, based on quantum chemical computations, is given in the Supporting Information; the main results are found in the paper. Furthermore, we show IR and Raman spectra of synthetic guaiacyl lignin (dehydrogenation polymer—G‐DHP). Raman spectra of DBDO and G‐DHP both differ with respect to the excitation wavelength and therefore reveal different features of the substructure/polymer. This study confirms the idea previously put forward that Raman at 532 nm selectively probes end groups of lignin, whereas Raman at 785 nm and IR seem to represent the majority of lignin substructures.
Prognostic value of muscle depletion assessed by computed tomography for surgical outcomes of cancer patients undergoing total esophagectomy and gastrectomy
Authors: Menezes Taysa M. , Dias Marina O. , dos Reis Ricardo , Elias Jorge , Lucchesi Fabiano R. , Araujo Raphael L. C. 
Published: January 2020

AbstractIntroductionConsidering the high morbimortality rate in oncologic surgeries of the gastrointestinal tract, especially in patients with malnutrition, the use of predictive tools is necessary, since preoperative strategies could improve postoperative outcomes.ObjectivesTo evaluate body composition by computed tomography and its association with morbimortality post esophagectomy and total gastrectomy.MethodsProspective cohort study (n = 80). Sociodemographic, diagnostic, treatment and postoperative data were collected. Anthropometric and biochemical (hemoglobin, transferrin, and albumin) data were evaluated. The muscle mass was calculated through two methods, the muscle mass index (MMI) and the psoas total area (PTA). For postoperative complications classification, the Clavien‐Dindo scale was used.ResultsThe prevalence of muscle depletion found was 33.8% by MMI and 61% by PTA (poor agreement, kappa = 0.25). Complication rates were 18.5% in gastrectomies and 50% in esophagectomies. No statistically significant difference was found between the presence of muscle depletion and complications. However, when stratified by surgery, a borderline association was found between the MMI and post esophagectomies complications (P = .05).ConclusionDespite the high prevalence of muscle loss, it was not possible to correlate it with surgical outcomes for gastrectomies, but for esophagectomies, there may be relevance due to borderline association, although patients received nutritional therapy.
Characterization of extremely low profile patch antenna loaded with periodic diamond metasurface ground plane
Authors: Deng Xiao , Xu Xiaofei , Wei Juzheng 
Published: January 2020

AbstractThe characterization of an extremely low profile patch antenna is studied which is loaded with periodic diamond metasurface ground plane. Compared with conventional patch antenna, the new antenna has a smaller patch size, increased bandwidth, and enhanced efficiency. These performances are numerically investigated and optimized. By loading an optimal metasurface structure, a particular patch antenna is demonstrated in experiments. Measured results show that the metasurface antenna is in extremely low profile of 0.0045λ0. The patch length is 0.245λ0 or 0.36λg which is far beyond the 0.5λg limitation associated with a conventional prototype. In addition, the metasurface antenna has an impedance bandwidth of 1.83% and radiation efficiency of 83% in measurement. These two parameters are observed to be limited at level of 0.69% and 69%, respectively for a conventional patch antenna.
Extrapolation methods for fixed‐point multilinear PageRank computations
Authors: Cipolla Stefano , Redivo‐Zaglia Michela , Tudisco Francesco 
Published: January 2020

SummaryNonnegative tensors arise very naturally in many applications that involve large and complex data flows. Due to the relatively small requirement in terms of memory storage and number of operations per step, the (shifted) higher order power method is one of the most commonly used technique for the computation of positive Z‐eigenvectors of this type of tensors. However, unlike the matrix case, the method may fail to converge even for irreducible tensors. Moreover, when it converges, its convergence rate can be very slow. These two drawbacks often make the computation of the eigenvectors demanding or unfeasible for large problems. In this work, we consider a particular class of nonnegative tensors associated with the multilinear PageRank modification of higher order Markov chains. Based on the simplified topological ε‐algorithm in its restarted form, we introduce an extrapolation‐based acceleration of power method type algorithms, namely, the shifted fixed‐point method and the inner‐outer method. The accelerated methods show remarkably better performance, with faster convergence rates and reduced overall computational time. Extensive numerical experiments on synthetic and real‐world datasets demonstrate the advantages of the introduced extrapolation techniques.
History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial
Authors:   Look AHEAD Research Group, Lewis Cora E. , Bantle John P. , Bertoni Alain G. , Blackburn George , Brancati Frederick L. , Bray George A. , Cheskin Lawrence J. , Curtis Jeffrey M. , Egan Caitlin , Evans Mary , Foreyt John P. , Ghazarian Siran , Barone Gibbs Bethany , Glasser Stephen P. , W. Gregg Edward , Hazuda Helen P. , Hesson Louise , Hill James O. , Horton Edward S. , Hubbard Van S. , Jakicic John M. , Jeffery Robert W. , Johnson Karen C. , Kahn Steven E. , Kitabchi Abbas E. , Kitzman Dalane , Knowler William C. , Lipkin Edward , Michaels Sara , Montez Maria G. , Nathan David M. , Nyenwe Ebenezer , Patricio Jennifer , Peters Anne , Pi‐Sunyer Xavier , Pownall Henry , Reboussin David M. , Ryan Donna H. , Wadden Thomas A. , Wagenknecht Lynne E. , Wyatt Holly , Wing Rena R. , Yanovski Susan Z. 
Published: January 2020

ObjectiveTo examine the effects of an intensive lifestyle intervention (ILI) on cardiovascular disease (CVD), the Action for Health in Diabetes (Look AHEAD) trial randomized 5,145 participants with type 2 diabetes and overweight/obesity to a ILI or diabetes support and education. Although the primary outcome did not differ between the groups, there was suggestive evidence of heterogeneity for prespecified baseline CVD history subgroups (interaction P = 0.063). Event rates were higher in the ILI group among those with a CVD history (hazard ratio 1.13 [95% CI: 0.90‐1.41]) and lower among those without CVD (hazard ratio 0.86 [95% CI: 0.72‐1.02]).MethodsThis study conducted post hoc analyses of the rates of the primary composite outcome and components, adjudicated cardiovascular death, nonfatal myocardial infarction (MI), stroke, and hospitalization for angina, as well as three secondary composite cardiovascular outcomes.ResultsInteraction P values for the primary and two secondary composites were similar (0.060‐0.064). Of components, the interaction was significant for nonfatal MI (P = 0.035). This interaction was not due to confounding by baseline variables, different intervention responses for weight loss and physical fitness, or hypoglycemic events. In those with a CVD history, statin use was high and similar by group. In those without a CVD history, low‐density lipoprotein cholesterol levels were higher (P = 0.003) and statin use was lower (P ≤ 0.001) in the ILI group.ConclusionsIntervention response heterogeneity was significant for nonfatal MI. Response heterogeneity may need consideration in a CVD‐outcome trial design.
Quantitative analysis of flavonols, flavonol glycoside and homoisoflavonoids in Polygonatum verticillatum using UHPLC‐DAD‐QTOF‐IMS and evaluation of their antioxidant potential
Authors: Sharma Shruti , Joshi Robin , Kumar Dinesh 
Published: January 2020

AbstractIntroductionPolygonatum is widely used as a part of food in different regions of the world which covers five main categories such as drinks, vegetables, snacks, staple and seasoning foods. Presently, no analytical method is available for the quality control of Polygonatum.ObjectiveDevelopment and validation of a method using ultrahigh‐performance liquid chromatography diode array detector quadrupole time‐of‐flight (UHPLC‐DAD/QTOF) technique for the estimation of six compounds including a flavonol glycoside [rutin (1)], two flavonols [quercetin (2) and kaempherol (3)] and three homoisoflavonoids [5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐chroman‐4‐one (4), 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐8‐methylchroman‐4‐one (5) and 5,7‐dihydroxy‐3‐(4‐methoxybenzyl)‐8‐methylchroman‐4‐one (6)]. In addition, screening of extract, fractions and compounds of P. verticillatum for antioxidant activity was also determined.MethodologyThe separation was achieved on C‐18 column using acetonitrile and water containing 0.1% formic acid. The method was validated as per ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use) guidelines. The validated method was applied for the simultaneous identification and quantification of compounds 1–6 in extract (E) and fractions (F1–F4) of P. verticillatum. Furthermore, antioxidant potential of E, F1 and F2 and compounds was evaluated using DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) assay.ResultsThe method was within the linear range (r2) of 0.982 to 0.999, precise (intra‐ and inter‐day percentage relative standard deviations < 2.72 and 2.26) and accurate with recoveries (89.1–98.3%). The limit of detection and limit of quantification were in the ranges 0.02–0.16 and 0.06–0.48 ng/mL, respectively. Compounds 1–6 were quantified in all the samples. Compounds 1, 2 and 5 showed higher activity with half maximal inhibitory concentration (IC50) values 0.41, 0.39, 0.72 at 10, 20 and 30 μg/mL, respectively.ConclusionDeveloped method will be helpful to assess the quality of P. verticillatum raw material and their derived products.
Continuous intravenous to oral morphine switch in very premature ventilated infants: A retrospective study on efficacy, efficiency, and tolerability
Authors: Duong Phoï , Tauzin Manon , Decobert Fabrice , Marchand Laetitia , Caeymaex Laurence , Durrmeyer Xavier 
Published: January 2020

AbstractBackgroundContinuous intravenous (IV) morphine is commonly used in ventilated neonates. Oral route is theoretically feasible but data on oral morphine in ventilated premature infants are lacking.ObjectiveTo assess the efficacy, efficiency, and tolerability of a continuous intravenous to oral morphine switch protocol.DesignRetrospective study.SettingSingle level III center's neonatal intensive care unit.PatientsVentilated premature infants hospitalized in the NICU in 2016 and 2017, receiving continuous IV morphine with an expected ventilation course of at least 72 more hours. We excluded patients treated for withdrawal syndrome or palliative care.InterventionsContinuous IV to oral morphine switch with the same initial cumulated daily dose.Main outcome measuresPain scores (ComfortNeo scale) and morphine doses were analyzed over time using Friedman's test in the 24 hours preceding and the 48 hours following the oral switch. Adverse effects attributable to opioids were collected.ResultsSeventeen infants were included with a median [IQR] gestational age at birth of 25.9 [24.6‐26.9] weeks and a median postnatal age at oral switch of 30 [22‐36] days. One patient's intravenous treatment had to be resumed because of a high ComfortNeo score. All others remained on oral morphine. No significant change over time was observed for ComfortNeo scores (P = .15). Median [IQR] doses were 13.5 [10‐20] µg/kg/h in the IV period and significantly increased to 15 [10‐25] µg/kg/h in the oral period (P = .009). No short‐term respiratory, digestive, or urinary adverse event was observed. After a median [IQR] duration of 13 [4‐20] days of oral morphine treatment, 11 (65%) patients showed signs of withdrawal. Upon hospital discharge, 16 infants (94%) had bronchopulmonary dysplasia and none had severe cerebral abnormality on brain imaging.ConclusionOral morphine might be useful in ventilated neonates in the NICU but deserves further studies and additional safety assessment.