bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene biomarker discovery at different stages of Alzheimer using gene co-expression network approach
Authors: Soleimani Zakeri Negar Sadat , Pashazadeh Saeid , MotieGhader Habib 
Published: July 2020

AbstractAlzheimer's disease (AD) is a chronic neurodegenerative disorder. It is the most common type of dementia that has remained as an incurable disease in the world, which destroys the brain cells irreversibly. In this study, a systems biology approach was adopted to discover novel micro-RNA and gene-based biomarkers of the diagnosis of Alzheimer's disease. The gene expression data from three AD stages (Normal, Mild Cognitive Impairment, and Alzheimer) were used to reconstruct co-expression networks. After preprocessing and normalization, Weighted Gene Co-Expression Network Analysis (WGCNA) was used on a total of 329 samples, including 145 samples of Alzheimer stage, 80 samples of Mild Cognitive Impairment (MCI) stage, and 104 samples of the Normal stage. Next, three gene-miRNA bipartite networks were reconstructed by comparing the changes in module groups. Then, the functional enrichment analyses of extracted genes of three bipartite networks and miRNAs were done, respectively. Finally, a detailed analysis of the authentic studies was performed to discuss the obtained biomarkers. The outcomes addressed proposed novel genes, including MBOAT1, ARMC7, RABL2B, HNRNPUL1, LAMTOR1, PLAGL2, CREBRF, LCOR, and MRI1and novel miRNAs comprising miR-615-3p, miR-4722-5p, miR-4768-3p, miR-1827, miR-940 and miR-30b-3p which were related to AD. These biomarkers were proposed to be related to AD for the first time and should be examined in future clinical studies.
The development of an ultra-sensitive electrochemical immunosensor using a PPyr-NHS functionalized disposable ITO sheet for the detection of interleukin 6 in real human serums
Authors: Aydın Elif Burcu , Aydın Muhammet , Sezgintürk Mustafa Kemal 
Published: July 2020

A label-free biosensor based on poly(pyrrole N-hydroxy succinimide) polymer modified ITO electrode was developed for sensitive detection of interleukin 6 antigen. Under optimized conditions, it had a wide detection range (0.03–22.5 pg mL−1).
The Use of Structural Priming and Focused Recasts to Facilitate the Production of Subject- and Object-Focused Relative Clauses by School-Age Children With and Without Developmental Language Disorder
Authors: Wada Rebekah , Gillam Sandra Laing , Gillam Ronald B. 
Published: July 2020

Purpose
The purpose of this study was to examine the use of structural priming combined with a focused recasting procedure to elicit subject- and object-focused, center-embedded relative clauses from students with developmental language disorders (DLDs) and typically developing (TD) students.

Method
A total of 26 children (13 DLD, 13 TD), ranging in age from 6;10 to 10;11 (years;months), participated in this study. All children completed a priming and recasting task that targeted subject- and object-focused relatives. The stimuli were presented in two blocks, which each contained 40 trials for each sentence type.

Results
Children with DLD and their TD peers were significantly more accurate producing subject-focused than object-focused relatives. An analysis of rate of learning indicated that significantly more trials were required for subjects in the DLD group to demonstrate consistent performance on both subject- and object-focused relatives.

Conclusions
The study supports the feasibility of combining an implicit priming task with an explicit recasting task for teaching subject-focused relative clauses to children with DLD. However, it is likely that additional instruction and/or more trials will be necessary for children with DLD to attain consistent performance levels.

Supplemental Material

https://doi.org/10.23641/asha.12670847
Part of Speech Production in Patients With Primary Progressive Aphasia: An Analysis Based on Natural Language Processing
Authors: Themistocleous Charalambos , Webster Kimberly , Afthinos Alexandros , Tsapkini Kyrana 
Published: July 2020

Background
Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a progressive decline of language functions. Its symptoms are grouped into three PPA variants: nonfluent PPA, logopenic PPA, and semantic PPA. Grammatical deficiencies differ depending on the PPA variant.

Aims
This study aims to determine the differences between PPA variants with respect to part of speech (POS) production and to identify morphological markers that classify PPA variants using machine learning. By fulfilling these aims, the overarching goal is to provide objective measures that can facilitate clinical diagnosis, evaluation, and prognosis.

Method and Procedure
Connected speech productions from PPA patients produced in a picture description task were transcribed, and the POS class of each word was estimated using natural language processing, namely, POS tagging. We then implemented a twofold analysis: (a) linear regression to determine how patients with nonfluent PPA, semantic PPA, and logopenic PPA variants differ in their POS productions and (b) a supervised classification analysis based on POS using machine learning models (i.e., random forests, decision trees, and support vector machines) to subtype PPA variants and generate feature importance (FI).

Outcome and Results
Using an automated analysis of a short picture description task, this study showed that content versus function words can distinguish patients with nonfluent PPA, semantic PPA, and logopenic PPA variants. Verbs were less important as distinguishing features of patients with different PPA variants than earlier thought. Finally, the study showed that among the most important distinguishing features of PPA variants were elaborative speech elements, such as adjectives and adverbs.
Tongue- and Jaw-Specific Articulatory Changes and Their Acoustic Consequences in Talkers With Dysarthria due to Amyotrophic Lateral Sclerosis: Effects of Loud, Clear, and Slow Speech
Authors: Mefferd Antje S. , Dietrich Mary S. 
Published: July 2020

PurposeThis study aimed to determine how tongue and jaw displacement changes impact acoustic vowel contrast in talkers with amyotrophic lateral sclerosis (ALS) and controls.MethodTen talkers with ALS and 14 controls participated in this study. Loud, clear, and slow speech cues were used to elicit tongue and jaw kinematic as well as acoustic changes. Speech kinematics was recorded using three-dimensional articulography. Independent tongue and jaw displacements were extracted during the diphthong /ai/ inkite. Acoustic distance between diphthong onset and offset in Formant 1–Formant 2 vowel space indexed acoustic vowel contrast.ResultsIn both groups, all three speech modifications elicited increases in jaw displacement (typical < slow < loud < clear). By contrast, only slow speech elicited significantly increased independent tongue displacement in the ALS group (typical = loud = clear < slow), whereas all three speech modifications elicited significantly increased independent tongue displacement in controls (typical < loud < clear = slow). Furthermore, acoustic vowel contrast significantly increased in response to clear and slow speech in the ALS group, whereas all three speech modifications elicited significant increases in acoustic vowel contrast in controls (typical < loud < slow < clear). Finally, only jaw displacements accounted for acoustic vowel contrast gains in the ALS group. In controls, however, independent tongue displacements accounted for increases in vowel acoustic contrast during loud and slow speech, whereas jaw and independent tongue displacements accounted equally for acoustic vowel contrast change during clear speech.ConclusionKinematic findings suggest that slow speech may be better suited to target independent tongue displacements in talkers with ALS than clear and loud speech. However, given that gains in acoustic vowel contrast were comparable for slow and clear speech cues in these talkers, future research is needed to determine potential differential impacts of slow and clear speech on perceptual measures, such as intelligibility. Finally, findings suggest that acoustic vowel contrast gains are predominantly jaw driven in talkers with ALS. Therefore, the acoustic and perceptual consequences of direct instructions of enhanced jaw movements should be compared to cued speech modification, such as clear and slow speech in these talkers.
The Advantages of Retrieval-Based and Spaced Practice: Implications for Word Learning in Clinical and Educational Contexts
Authors: Gordon Katherine R. 
Published: July 2020

Purpose
Researchers in the cognitive sciences have identified several key training strategies that support good encoding and retention of target information. These strategies are retrieval-based practice, also known as learning through testing, and spaced practice. The recent resurgence of research on retrieval-based and spaced practice has been extended to investigate the effectiveness of these strategies to support learning in individuals with language disorders. The purpose of the current article is to review key principles of retrieval-based and spaced practice that can be used to support word learning in individuals within clinical and educational contexts.

Conclusion
Current research provides evidence that principles of retrieval-based and spaced practice can enhance word learning for individuals with language disorders. Current research provides guidance for clinicians on how to implement these strategies both within and across sessions to support encoding and retention of target information. Additional research should be conducted to provide a better understanding of how to optimize encoding and retention in clinical and educational contexts. Most notably, research that examines long-term retention after interventions are withdrawn would further our understanding of how these principles can be optimally applied to improve outcomes for individuals with language disorders.
Time Requirement and Feasibility of a Systematic Quality Peer Review of Reporting in Radiology
Authors: Maurer Martin H. , Brönnimann Michael , Schroeder Christophe , Ghadamgahi Ehssan , Streitparth Florian , Heverhagen Johannes T. , Leichtle Alexander , de Bucourt Maximilian , Meyl Tobias Philipp 
Published: July 2020

Objective To estimate the human resources required for a retrospective quality review of different percentages of all routine diagnostic procedures in the Department of Radiology at Bern University Hospital, Switzerland.
Materials and Methods Three board-certified radiologists retrospectively evaluated the quality of the radiological reports of a total of 150 examinations (5 different examination types: abdominal CT, chest CT, mammography, conventional X-ray images and abdominal MRI). Each report was assigned a RADPEER score of 1 to 3 (score 1: concur with previous interpretation; score 2: discrepancy in interpretation/not ordinarily expected to be made; score 3: discrepancy in interpretation/should be made most of the time). The time (in seconds, s) required for each review was documented and compared. A sensitivity analysis was conducted to calculate the total workload for reviewing different percentages of the total annual reporting volume of the clinic.
Results Among the total of 450 reviews analyzed, 91.1 % (410/450) were assigned a score of 1 and 8.9 % (40/450) were assigned scores of 2 or 3. The average time (in seconds) required for a peer review was 60.4 s (min. 5 s, max. 245 s). The reviewer with the greatest clinical experience needed significantly less time for reviewing the reports than the two reviewers with less clinical expertise (p < 0.05). Average review times were longer for discrepant ratings with a score of 2 or 3 (p < 0.05). The total time requirement calculated for reviewing all 5 types of examination for one year would be more than 1200 working hours.
Conclusion A retrospective peer review of reports of radiological examinations using the RADPEER system requires considerable human resources. However, to improve quality, it seems feasible to peer review at least a portion of the total yearly reporting volume.
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Retroperitoneal Fibrosis and its Differential Diagnoses: The Role of Radiological Imaging
Authors: Peisen Felix , Thaiss Wolfgang Maximilian , Ekert Kaspar , Horger Marius , Amend Bastian , Bedke Jens , Nikolaou Konstantin , Kaufmann Sascha 
Published: July 2020

Background Retroperitoneal fibrosis is a rare disease with an incidence of 0–1/100 000 inhabitants per year and is associated with chronic inflammatory fibrosis of the retroperitoneum and the abdominal aorta. This article sheds light on the role of radiological imaging in retroperitoneal fibrosis, names various differential diagnoses and provides an overview of drug and surgical treatment options.
Methods A literature search for the keywords “retroperitoneal fibrosis” and “Ormond’s disease” was carried out in the PubMed database between January 1, 1995 and December 31, 2019 (n = 1806). Mainly original papers were selected, but also reviews, in English and German language, with a focus on publications in the last 10 years, without excluding older publications that the authors believe are relevant to the topic discussed in the review (n = 40).
Results and Conclusion Ormond’s disease is a rare but important differential diagnosis for nonspecific back and flank pain. Imaging diagnostics using CT or MRI show a retroperitoneal mass, which must be differentiated from lymphoma, sarcoma, multiple myeloma and Erdheim-Chester disease. Patients have an excellent prognosis under adequate therapy. FDG-PET/CT or FDG-PET/MRT should be considered as potential modalities, as hybrid imaging can evaluate both the morphological changes and the inflammation.
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Minimal Stabilization Time for Ultra-short Heart Rate Variability Measurements in Professional Soccer
Authors: Forner-Llacer Francisco , Aranda-Malaves Rodrigo , Aranda Malavés Rafael , Calleja-Gonzalez Julio , Perez-Turpin Jose Antonio , Gonzalez-Rodenas Joaquin 
Published: July 2020

ABSTRACTThe main aims of this study were: 1) to compare 1-minute RMSSD measurements using different stabilization times between them and also with the criterion; and 2) to determine the agreement between every 1-minute RMSSD measurement with the criterion in professional soccer players. Seven hundred eighteen HRV measurements from professional soccer players were taken. HRV was calculated from 5 to 10 minutes (criterion) and from 1-minute windows with different pre-stabilization times. Friedman and post-hoc tests were applied to compare 1-minute and criterion measurements. Effect size was considered to describe magnitude of change. To determine agreement, Spearman’s correlation was applied, and Bland–Altman analysis was also done between each ultra-short HRV time window and the 5-minute HRV criterion period. The 1-minute HRV without any pre-stabilization time was the only one different from all the other 1-minute measurements that included 1 or more minutes of pre-stabilization (p<0.001). One-minute HRV measurements with 1 or more minutes of pre-stabilisation were highly correlated with those for the criterion period. One-minute HRV without pre-stabilization showed the lowest correlation and the highest bias from the criterion. It is concluded that 1-minute HRV measurements with a prior 1-minute or longer pre-stabilization time are valid to measure HRV in professional male soccer players.
DNVF Memorandum Gesundheitskompetenz (Teil 1) – Hintergrund,
Relevanz, Gegenstand und Fragestellungen in der
Versorgungsforschung
Authors: Ernstmann Nicole , Bauer Ullrich , Berens Eva-Maria , Bitzer Eva Maria , Bollweg Torsten Michael , Danner Martin , Dehn-Hindenberg Andrea , Dierks Marie Luise , Farin Erik , Grobosch Sandra , Haarig Frederik , Halbach Sarah , Hollederer Alfons , Icks Andrea , Kowalski Christoph , Kramer Ursula , Neugebauer Edmund , Okan Orkan , Pelikan Jürgen , Pfaff Holger , Sautermeister Jochen , Schaeffer Doris , Schang Laura , Schulte Hilde , Siegel Achim , Sundmacher Leonie , Vogt Dominique , Vollmar Horst Christian , Stock Stephanie 
Published: July 2020

ZusammenfassungMehr als die Hälfte der deutschen Bevölkerung hat Schwierigkeiten
im Umgang mit Gesundheitsinformationen. Es ist eine wichtige Aufgabe der
Versorgungsforschung zu untersuchen, wie sich die Professionen und
Organisationen des Gesundheitssystems dieser Herausforderung stellen
können. Das DNVF Memorandums Gesundheitskompetenz (Teil 1) nimmt
Begriffsbestimmungen der individuellen und organisationalen Gesundheitskompetenz
vor, präsentiert den nationalen und internationalen Forschungsstand und
stellt ethische Aspekte der versorgungsbezogenen Gesundheitskompetenzforschung
dar. Weiterhin wird die Relevanz der Gesundheitskompetenzforschung in
verschiedenen Lebensphasen, bei unterschiedlichen Personengruppen sowie in
verschiedenen Kontexten der Gesundheits- und Krankenversorgung erarbeitet. Vor
diesem Hintergrund werden zentrale Forschungsgegenstände und
zukünftige Forschungsdesiderata abgeleitet.
Flattening the COVID-19 Curve: The Impact of Contact Restrictions on
the Infection Curve in Germany
Authors: Valentowitsch Johann 
Published: July 2020

AbstractAlthough Germany is coping well with the coronavirus crisis, many voices are
currently being raised that fundamentally question the success of the contact
restriction strategy to contain the virus. I show in this study that there is no
justification for such criticism. In fact, contact restrictions have flattened
the infection curve and were possibly decisive for the good German performance
in the crisis.
Kostenvergleichsanalyse von flexiblen HNO-Endoskopen
Authors: Becker Sven , Thum Katharina , Philipp Julia , Hagemann Jan , Eckrich Jonas , Ernst Benjamin 
Published: July 2020

Zusammenfassung
Hintergrund Die hygienische, richtliniengetreue Wiederaufbereitung von komplexen Instrumenten wie flexiblen HNO-Endoskopen mit und ohne Arbeitskanal stellt Kliniken und Praxen zunehmend vor große Herausforderungen. Ziel der vorliegenden Studie war es daher, die Kosten für ein wiederaufbereitbares Endoskopie-System mit 2 Einweg-Endoskopie-Systemen zu vergleichen und daraus mögliche strategische Überlegungen abzuleiten.
Methodik Hierzu wurde eine Kostenvergleichsanalyse bzw. Kostenminimierungsanalyse des an der Hals-, Nasen-, Ohrenklinik und Poliklinik der Universitätsmedizin Mainz vorgehaltenen Endoskopie-Systems mit 2 Einweg-Endoskopie-Systemen der Firma Ambu und Karl Storz durchgeführt.
Ergebnisse Die Berechnung der Gesamtkosten des wiederaufbereitbaren Endoskopie-Systems ergab einen Gesamtbetrag von 23,03 € pro Untersuchung (11,60 € Investitionskosten + 5,09 € Reparaturkosten + 6,34 € Wiederaufbereitungskosten). Das Einweg-Endoskopie-System der Firma Ambu schlug mit 120,43 € pro Untersuchung (120,00 € Anschaffungskosten + 0,43 € Lagerungskosten) zu Buche. Das Einweg-Endoskopie-System der Firma Karl Storz kostete 223,44 € pro Untersuchung (Investitionskosten für Monitor 3,01 € + 220,00 € Anschaffungskosten + 0,43 € Lagerungskosten).
Diskussion Flexible HNO-Einweg-Endoskope verursachen im Vergleich zu konventionellen, wiederaufbereitbaren Systemen höhere Kosten. Aus medizinischer, aber auch ökonomischer Sicht bieten sie jedoch auch Vorteile.
Schlussfolgerung Ein guter Mix aus wiederaufbereitbaren Endoskopie-Systemen und Einweg-Systemen, z. B. zur Behandlung von Patienten mit Besiedelung durch kritische Erreger, erscheint daher sinnvoll.
Post-Cesarean Peritonitis Caused by Hysterorrhaphy Dehiscence with
Puerperal Acute Abdomen Syndrome
Authors: Pavoković Dino , Cerovac Anis , Ljuca Dženita , Habek Dubravko 
Published: July 2020

AbstractWe present an overview of the case of a patient with early hysterorrhaphy
dehiscence (uteroperitoneal fistula) with endomyometritis and post-cesarean
section peritonitis and puerperal acute abdomen in a 35-year-old puerpera. A
exploratory relaparotomy, necrectomy, and resuture of the dehiscent part of the
hysterotomy were performed with placement of hemostatic sponges on the same
portion of the uterus with good recovery.
The Myth of May Thurner
Authors: Toonder Irwin M. 
Published: July 2020

AbstractLess invasive contemporary endovenous techniques with improved stents have made treatment of the May Thurner Syndrome(MTS) more accessible and safer. However, clear criteria for the accurate diagnosis remain obscure. All imaging modalities are performed with patients in a supine position were compression of the left Common Iliac Vein is seen in both asymptomatic and symptomatic patients. There is no clear threshold value. There are no validated hemodynamic criteria. This leads to the necessity of additional information such as measurements performed in an upright position as well as greater scrutiny in detecting fibrous wall thickening and spurs as well as identifying the presence of venous collaterals. Moreover, those contemplating treating MTS should not only identify specific symptoms, but also should consider that patient complaints may be related to a more complex presentation of pelvic congestion.
Specifications Grading: What It Is, and Lessons Learned
Authors: Leslie Paula , Lundblom Erin 
Published: July 2020

AbstractTraditional point-based grading is failing students entering a competency-based workforce: Employers require concrete skills and knowledge, not “high” grades. In the specifications approach, learning outcomes are explicitly linked to the grading system. The basic components of the approach include clear alignment of learning outcomes to certification standards, bundled sequences of assessments tied to basic and advanced competency/learning outcomes, pass/fail grading with no partial credit, opportunities to revise unacceptable work, and detailed expectations of performance on assessments. This article describes the specifications approach and provides examples highlighting how to (1) align course learning objectives with a grading system, (2) implement a pass/fail approach even for complex assessment, (3) define specifications, (4) create and sequence bundles of assessments, and (5) provide instructor support through feedback and tokens.