bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral versus unilateral hip arthroscopy for femoroacetabular impingement: a systematic review
Authors: Fernandez Claire E , Morgan Allison M , Sheth Ujash , Tjong Vehniah K , Terry Michael A 
Published: March 2020

AbstractOne in four patients presenting with femoroacetabular impingement (FAI) has bilateral symptoms, and despite excellent outcomes reported after arthroscopic treatment of FAI, there remains a paucity of data on the outcomes following bilateral hip arthroscopy. This systematic review aims to examine the outcomes following bilateral (either ‘simultaneous’ or ‘staged’) versus unilateral hip arthroscopy for FAI. A systematic review of multiple electronic databases was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and checklist. All studies comparing simultaneous, staged and/or unilateral hip arthroscopy for FAI were eligible for inclusion. Case series, case reports and reviews were excluded. All study, patient and hip-specific data were extracted and analyzed. The Newcastle–Ottawa Scale was used to assess study quality. A meta-analysis was not performed due to heterogeneity among outcome measures. A total of six studies, including 722 patients (42.8% male) and 933 hips were eligible for inclusion. The mean age across patients was 35.5. The average time between staged procedures was 7.7 months. Four of the six studies were retrospective cohort studies, while the remaining two were prospective in nature. The overall quality of the eligible studies was found to be good. No significant difference was noted among patient-reported outcomes (modified Harris hip score, hip outcome score and non-arthritic hip score), visual analog scale, return to sport, traction time and complications between those undergoing bilateral (simultaneous or staged) versus unilateral hip arthroscopy. Based on the current available evidence, bilateral hip arthroscopy (whether simultaneous or staged) exhibits similar efficacy and safety when compared with unilateral hip arthroscopy. However, further prospective study is required to confirm this finding.
Experiences and hidden needs of older patients, their families and their physicians in palliative chemotherapy decision-making: a qualitative study
Authors: Tsuboi Rie , Sugishita Mihoko , Hirakawa Yoshihisa , Ando Yuichi 
Published: March 2020

Abstract

Objective
This study aimed to clarify the experiences and hidden needs of older patients with advanced cancer, their families and their physicians in palliative chemotherapy decision-making.

Materials and Methods
We conducted in-depth qualitative individual interviews with content analysis. Patients who were diagnosed as having advanced cancer, were aged ≥70 years (n = 15, median [range] = 77 [70–82] years) and had volunteered to receive palliative chemotherapy within the past 6 months were enrolled. Their families and physicians were also interviewed.

Results
The following four themes were identified: (i) physician’s awareness of paternalism; (ii) readiness for communication of serious news; (iii) spiritual care need assessment and (iv) support as a team. The patients and families expected physicians to demonstrate paternalism in their decision-making because they were unconfident about their self-determination capability. Although the physicians were aware of this expectation, they encountered difficulties in recommending treatment and communicating with older patients. The patients had spiritual pain since the time of diagnosis. Psychological issues were rarely discussed during decision-making and treatment, triggering feelings of isolation in the patients and their families.

Conclusion
Older patients and their families expected a paternalistic approach by the physicians for palliative chemotherapy decision-making. The physicians found it difficult to offer treatment options because of older patient diversity and limitations in evidence-based strategies. Therefore multidisciplinary approaches and evidence-based decision support aids are warranted. Because older patients and their families often have unexpressed psychological burdens including unmet spiritual needs, medical professionals should provide psychological care from the time of diagnosis.
Generation of liver bipotential organoids with a small-molecule cocktail
Authors: Wang Xin , Ni Chao , Jiang Ning , Wei Jinsong , Liang Jianqing , Zhao Bing , Lin Xinhua 
Published: March 2020

Abstract
Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecule compounds. CHIR-99021, blebbistatin, and forskolin together maintained the liver organoids in bipotential stage with both cholangiocyte- and hepatocyte-specific gene expression profiles and enhanced capacity for further hepatocyte differentiation. By employing a chemical approach, we demonstrated that Wnt/β-catenin, NMII–Rac, and PKA–ERK are core signaling pathways essential and sufficient for mouse liver progenitor expansion. Moreover, the advanced small-molecule culture of bipotential organoids facilitates the ex vivo investigation of liver cell fate determination and the application of organoids in liver regenerative medicine.
Recent advances in computational methods for measurement of dendritic spines imaged by light microscopy
Authors: Okabe Shigeo 
Published: March 2020

Abstract
Dendritic spines are small protrusions that receive most of the excitatory inputs to the pyramidal neurons in the neocortex and the hippocampus. Excitatory neural circuits in the neocortex and hippocampus are important for experience-dependent changes in brain functions, including postnatal sensory refinement and memory formation. Several lines of evidence indicate that synaptic efficacy is correlated with spine size and structure. Hence, precise and accurate measurement of spine morphology is important for evaluation of neural circuit function and plasticity. Recent advances in light microscopy and image analysis techniques have opened the way toward a full description of spine nanostructure. In addition, large datasets of spine nanostructure can be effectively analyzed using machine learning techniques and other mathematical approaches, and recent advances in super-resolution imaging allow researchers to analyze spine structure at an unprecedented level of precision. This review summarizes computational methods that can effectively identify, segment and quantitate dendritic spines in either 2D or 3D imaging. Nanoscale analysis of spine structure and dynamics, combined with new mathematical approaches, will facilitate our understanding of spine functions in physiological and pathological conditions.
Evaluating Economic Impacts of Prescribed Fire in the Central Hardwood Region
Authors: Mann David P , Wiedenbeck Jan K , Dey Daniel C , Saunders Mike R 
Published: March 2020

AbstractSurface fires are often prescribed to favor oak (Quercus) regeneration in eastern forests, but there is potential for fire to damage residual overstory timber. This study evaluated the potential economic effects of prescribed fire on sawtimber volume and value across 139 stands, each with a known history of one to six prescribed fires, on the Hoosier, Mark Twain, Wayne, and Daniel Boone National Forests. Sawtimber volume and value losses were highly variable, ranging from 0 to 2,269 bd ft ac–1 and from US$0 to US$272.95 ac–1, respectively, for stands that had received at least one prescribed fire. Volume and value losses increased linearly by +0.9 percent and +1.5 percent per burn, respectively, that a stand received over the past 25 years. Stands with south-facing aspects had greater relative volume and value losses (+1.4 to +1.5 percent, respectively), but this influence was statistically less important than the number of burns in predictive models. The eastern national forests had much lower average relative volume and value losses, &lt;3.0 percent, than the more western Mark Twain National Forest (10–15 percent loss). Species composition affected value loss associated with prescribed fire; red oaks experienced significantly higher value loss than all other species groups.
The Decline of the Clearcut: 26 Years of Change in Silvicultural Practices and Implications in Minnesota
Authors: Windmuller-Campione M A , Russell M B , Sagor E , D’Amato A W , Ek A R , Puettmann K J , Rodman M G 
Published: March 2020

AbstractSilvicultural decisions and forest-management practices in Minnesota represent the collaboration and partnership between forest managers from multiple organizations and forest researchers. To better understand current practices, trends, needs, and opportunities, Minnesota has invested in the collection of quantitative data on the application of silvicultural systems and forest-management activities in 1991, 1996, 2008, and 2017. Drawing on those data, the goal of our study is to summarize 26 years of data to characterize and quantify trends in forest-management practices. During this period of time, timberland ownership (acres) has increased, whereas harvested volume has decreased (cords). Across state, federal, county, forest industry, and tribal forest lands, which collectively represent the majority of timberlands in Minnesota, the clearcut system decreased from 91% of the harvested area in 1991 to 72 percent in 2017. In contrast, the proportion of total harvested area as part of shelterwood, seed tree, selection, and thinning treatments all more than doubled from 1991 to 2017. Factors influencing the changes relate to forest health and diseases, shifts in ownership structure, and shifts in organizational policy and/or goals. The factors identified mirror many of the trends forest managers are experiencing in other regions, nationally and internationally.
The 3Fs Perfect In Omani Mehri
Authors: Bendjaballah Sabrina , Rubin Aaron D 
Published: March 2020

Abstract
For Antoine Lonnet
In the Mehri language as spoken in Oman, the suffix of the 3fs perfect has the three allomorphs -ōt, -ūt or -ēt. The distribution of these suffixes has never been fully described, in part because, until recently, transcriptions of Mehri often masked the subtle difference between ō and ū. The choice of 3fs suffix depends on the verbal stem and, in some cases, on the nature of certain root consonants. All the 3fs suffixes can be traced to a Proto-Semitic suffix *-at, which has been subjected to several sound rules specific to Omani Mehri, though analogy has also played a role in some verb types.
Social Smoking and French Fancies: The Dublin Art(s) Club, 1886–98
Authors: Milligan Kathryn 
Published: March 2020

Abstract
ABSTRACT
The Dublin Art(s) Club, which operated in the Irish capital from 1886 to 1898, offers an intriguing case study for modes of artistic networks and cultural exchange between Ireland and Britain in the closing decades of the nineteenth century. Despite this, the history of the Club has been little explored in historiography to date, often confused with other ventures by artists in the city. Examining the rise and fall of the Dublin Art(s) Club, along with its members and activities, this article retrieves its history and posits that it offers an example of an aspect of art in Ireland which was conspicuous for its cosmopolitan outlook and active engagement with the wider British art world, which then spanned across both islands. The history of the Dublin Art(s) Club poses a challenge to the extant scholarship of this period in Irish art history, which to date has been largely understood to be focused on themes of national identity, the cultural revival, and artists who left Ireland to train in Belgium and France. This article posits that by re-engaging with the activities of art clubs and societies, a more complex reading of artistic life in Victorian Dublin can emerge.
Virus-induced flowering—a tool for cereals
Authors: Ayre Brian G , El-Gebaly Fathy E , McGarry Roisin C 
Published: March 2020

This article comments on:Yuan C, Li H, Qin C, Zhang X, Chen Q, Zhang P, Xu X, He M, Zhang X, Tör M, Xue Dawei, Wang H, Jackson S, He Y, Liu Y, Shi N, Hong Y. 2020. Foxtail mosaic virus-induced flowering assays in monocot crops. Journal of Experimental Botany 71, 3012–3023.
To TDE or not to TDE: the luminous transient ASASSN-18jd with TDE-like and AGN-like qualities
Authors: Neustadt J M M , Holoien T W-S , Kochanek C S , Auchettl K , Brown J S , Shappee B J , Pogge R W , Dong Subo , Stanek K Z , Tucker M A , Bose S , Chen Ping , Ricci C , Vallely P J , Prieto J L , Thompson T A , Coulter D A , Drout M R , Foley R J , Kilpatrick C D , Piro A L , Rojas-Bravo C , Buckley D A H , Gromadzki M , Dimitriadis G , Siebert M R , Do A , Huber M E , Payne A V 
Published: March 2020

ABSTRACT
We present the discovery of ASASSN-18jd (AT 2018bcb), a luminous optical/ultraviolet(UV)/X-ray transient located in the nucleus of the galaxy 2MASX J22434289–1659083 at z = 0.1192. Over the year after discovery, Swift UltraViolet and Optical Telescope (UVOT) photometry shows the UV spectral energy distribution of the transient to be well modelled by a slowly shrinking blackbody with temperature $T \sim 2.5 \times 10^{4} \, {\rm K}$, a maximum observed luminosity of $L_{\rm max} = 4.5^{+0.6}_{-0.3}\times 10^{44} \, {\rm erg \,s}^{-1}$, and a radiated energy of $E = 9.6^{+1.1}_{-0.6} \times 10^{51} \, {\rm erg}$. X-ray data from Swift X-Ray Telescope (XRT) and XMM–Newton show a transient, variable X-ray flux with blackbody and power-law components that fade by nearly an order of magnitude over the following year. Optical spectra show strong, roughly constant broad Balmer emission and transient features attributable to He ii, N iii–v, O iii, and coronal Fe. While ASASSN-18jd shares similarities with tidal disruption events (TDEs), it is also similar to the newly discovered nuclear transients seen in quiescent galaxies and faint active galactic nuclei (AGNs).
The M dwarf problem: Fe and Ti abundances in a volume-limited sample of M dwarf stars
Authors: Woolf Vincent M , Wallerstein George 
Published: March 2020

ABSTRACT
We report iron and titanium abundance measurements from high-resolution spectra in a volume-limited sample of 106 M0 and M0.5 dwarf stars. The sample includes stars north of the celestial equator and closer than 29 parsecs. The results imply that there is an M dwarf problem similar to the previously known G dwarf problem, in that the fraction of low-metallicity M dwarfs is not large enough to fit simple closed-box models of Galactic chemical evolution. This volume-limited sample avoids many of the statistical uncertainties present in a previous study using a brightness-limited sample of M dwarf stars.
Classification and evolution of galaxies according to the dynamical state of host clusters and galaxy luminosities
Authors: Morell D F , Ribeiro A L B , de Carvalho R R , Rembold S B , Lopes P A A , Costa A P 
Published: March 2020

ABSTRACT
We analyse the dependence of galaxy evolution on cluster dynamical state and galaxy luminosity for a sample of 146 galaxy clusters from the Yang SDSS catalogue. Clusters were split according to their velocity distribution in Gaussians (G) and Non-Gaussians (NG), and further divided by luminosity regime. We performed a classification in the plane of mean stellar age versus specific star formation rate, providing three classes: star-forming (SF), passive (PAS) and intermediate (GV – green valley). We show that galaxies evolve in the same way in G and NG systems, but also suggest that their formation histories lead to different mixtures of galactic types and infall patterns. Separating the GV into star-forming and passive components, we find more bright galaxies in the passive mode of NG systems than in that of G systems. We also find more intermediate faint galaxies in the star-forming component of NG systems than in that of G systems. Our results suggest that GV is the stage where the transition from types Sab and Scd to S0 must be taking place, but the conversion between morphological types is independent of the dynamical stage of the clusters. Analysing the velocity dispersion profiles, we find that objects recently infalling onto clusters have a different composition between G and NG systems. While all galaxy types infall on to G systems, Sab and Scd dominate the infall on to NG systems. Finally, we find that faint Scd galaxies in the outskirts of NG systems present higher asymmetries relative to the mean asymmetry of field galaxies, suggesting that there are environmental effects acting on these objects.
The redshift and the host galaxy of the neutrino candidate 4FGL J0955.1+3551 (3HSP J095507.9+355101)
Authors: Paiano Simona , Falomo Renato , Padovani Paolo , Giommi Paolo , Gargiulo Adriana , Uslenghi Michela , Rossi Andrea , Treves Aldo 
Published: March 2020

ABSTRACT
The BL Lac object 4FGL J0955.1+3551 has been suggested as a possible source of ultra-energetic neutrinos detected by the IceCube observatory. The target was observed in 2020 January at the Large Binocular Telescope. Our spectroscopy (4100–8500 Å) yields a firm redshift z = 0.557 as deduced by the absorption lines of the host galaxy. The upper limit of the minimum equivalent width on emission lines is ∼0.3 Å. From the source image, we are able to resolve the host galaxy for which we measure an absolute magnitude M(R) = −22.9 and Re = 8 kpc, which are values which are typical of the host galaxies of BL Lacs.
Rapid Accumulation of Mutations in Growing Mycelia of a Hypervariable Fungus Schizophyllum commune
Authors: Bezmenova Aleksandra V , Zvyagina Elena A , Fedotova Anna V , Kasianov Artem S , Neretina Tatiana V , Penin Aleksey A , Bazykin Georgii A , Kondrashov Alexey S 
Published: March 2020

Abstract
The basidiomycete Schizophyllum commune has the highest level of genetic polymorphism known among living organisms. In a previous study, it was also found to have a moderately high per-generation mutation rate of 2×10−8, likely contributing to its high polymorphism. However, this rate has been measured only in an experiment on Petri dishes, and it is unclear how it translates to natural populations. Here, we used an experimental design that measures the rate of accumulation of de novo mutations in a linearly growing mycelium. We show that S. commune accumulates mutations at a rate of 1.24×10−7 substitutions per nucleotide per meter of growth, or ∼2.04×10−11 per nucleotide per cell division. In contrast to what has been observed in a number of species with extensive vegetative growth, this rate does not decline in the course of propagation of a mycelium. As a result, even a moderate per-cell-division mutation rate in S. commune can translate into a very high per-generation mutation rate when the number of cell divisions between consecutive meiosis is large.
The Origin of Additive Genetic Variance Driven by Positive Selection
Authors: Liu Li , Wang Yayu , Zhang Di , Chen Zhuoxin , Chen Xiaoshu , Su Zhijian , He Xionglei 
Published: March 2020

Abstract
Fisher’s fundamental theorem of natural selection predicts no additive variance of fitness in a natural population. Consistently, studies in a variety of wild populations show virtually no narrow-sense heritability (h2) for traits important to fitness. However, counterexamples are occasionally reported, calling for a deeper understanding on the evolution of additive variance. In this study, we propose adaptive divergence followed by population admixture as a source of the additive genetic variance of evolutionarily important traits. We experimentally tested the hypothesis by examining a panel of ∼1,000 yeast segregants produced by a hybrid of two yeast strains that experienced adaptive divergence. We measured &gt;400 yeast cell morphological traits and found a strong positive correlation between h2 and evolutionary importance. Because adaptive divergence followed by population admixture could happen constantly, particularly in species with wide geographic distribution and strong migratory capacity (e.g., humans), the finding reconciles the observation of abundant additive variances in evolutionarily important traits with Fisher’s fundamental theorem of natural selection. Importantly, the revealed role of positive selection in promoting rather than depleting additive variance suggests a simple explanation for why additive genetic variance can be dominant in a population despite the ubiquitous between-gene epistasis observed in functional assays.
Adaptive Shifts in Gene Regulation Underlie a Developmental Delay in Thermogenesis in High-Altitude Deer Mice
Authors: Velotta Jonathan P , Robertson Cayleih E , Schweizer Rena M , McClelland Grant B , Cheviron Zachary A 
Published: March 2020

AbstractAerobic performance is tied to fitness as it influences an animal’s ability to find food, escape predators, or survive extreme conditions. At high altitude, where low O2 availability and persistent cold prevail, maximum metabolic heat production (thermogenesis) is an aerobic performance trait that is closely linked to survival. Understanding how thermogenesis evolves to enhance survival at high altitude will yield insight into the links between physiology, performance, and fitness. Recent work in deer mice (Peromyscus maniculatus) has shown that adult mice native to high altitude have higher thermogenic capacities under hypoxia compared with lowland conspecifics, but that developing high-altitude pups delay the onset of thermogenesis. This finding suggests that natural selection on thermogenic capacity varies across life stages. To determine the mechanistic cause of this ontogenetic delay, we analyzed the transcriptomes of thermoeffector organs—brown adipose tissue and skeletal muscle—in developing deer mice native to low and high altitude. We demonstrate that the developmental delay in thermogenesis is associated with adaptive shifts in the expression of genes involved in nervous system development, fuel/O2 supply, and oxidative metabolism pathways. Our results demonstrate that selection has modified the developmental trajectory of the thermoregulatory system at high altitude and has done so by acting on the regulatory systems that control the maturation of thermoeffector tissues. We suggest that the cold and hypoxic conditions of high altitude force a resource allocation tradeoff, whereby limited energy is allocated to developmental processes such as growth, versus active thermogenesis, during early development.
OLGenie: Estimating Natural Selection to Predict Functional Overlapping Genes
Authors: Nelson Chase W , Ardern Zachary , Wei Xinzhu 
Published: March 2020

Abstract
Purifying (negative) natural selection is a hallmark of functional biological sequences, and can be detected in protein-coding genes using the ratio of nonsynonymous to synonymous substitutions per site (dN/dS). However, when two genes overlap the same nucleotide sites in different frames, synonymous changes in one gene may be nonsynonymous in the other, perturbing dN/dS. Thus, scalable methods are needed to estimate functional constraint specifically for overlapping genes (OLGs). We propose OLGenie, which implements a modification of the Wei-Zhang method. Assessment with simulations and controls from viral genomes (58 OLGs and 176 non-OLGs) demonstrates low false positive rates and good discriminatory ability in differentiating true OLGs from non-OLGs. We also apply OLGenie to the unresolved case of HIV-1’s putative antisense protein gene, showing significant purifying selection. OLGenie can be used to study known OLGs and to predict new OLGs in genome annotation. Software and example data are freely available at https://github.com/chasewnelson/OLGenie.