bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Different Spacers on Biological Profile of Peptide Radiopharmaceuticals for Diagnosis and Therapy of Human Cancers
Authors: Farahani Arezou M. , Maleki Fariba , Sadeghzadeh Nourollah 
Published: December 2019

Background:
Cancer is the leading cause of death worldwide. Early detection can reduce the disadvantageous
effects of diseases and the mortality in cancer. Nuclear medicine is a powerful tool that has the ability
to diagnose malignancy without harming normal tissues. In recent years, radiolabeled peptides have been
investigated as potent agents for cancer detection. Therefore, it is necessary to modify radiopeptides in order to
achieve more effective agents.

Objective:
This review describes modifications in the structure of radioconjugates with spacers who have improved
the specificity and sensitivity of the peptides that are used in oncologic diagnosis and therapy.

Methods:
To improve the biological activity, researchers have conjugated these peptide analogs to different
spacers and bifunctional chelators. Many spacers of different kinds, such as hydrocarbon chain, amino acid
sequence, and poly (ethyleneglycol) were introduced in order to modify the pharmacokinetic properties of these
biomolecules.

Results:
Different spacers have been applied to develop radiolabeled peptides as potential tracers in nuclear
medicine. Spacers with different charge and hydrophilicity affect the characteristics of peptide conjugate. For
example, the complex with uncharged and hydrophobic spacers leads to increased liver uptake, while the composition
with positively charged spacers results in high kidney retention. Therefore, the pharmacokinetics of
radio complexes correlates to the structure and total charge of the conjugates.

Conclusion:
Radio imaging technology has been successfully applied to detect a tumor in the earliest stage. For
this purpose, the assessment of useful agents to diagnose the lesion is necessary. Developing peptide radiopharmaceuticals
using spacers can improve in vitro and in vivo behavior of radiotracers leading to better noninvasive
detection and monitoring of tumor growth.
An App Developed for Detecting Nurse Burnouts Using the Convolutional Neural Networks in Microsoft Excel: Population-Based Questionnaire Study
Authors: Lee Yi-Lien , Chou Willy , Chien Tsair-Wei , Chou Po-Hsin , Yeh Yu-Tsen , Lee Huan-Fang 
Published: December 2019

Background
Burnout (BO), a critical syndrome particularly for nurses in health care settings, substantially affects their physical and psychological status, the institute’s well-being, and indirectly, patient outcomes. However, objectively classifying BO levels has not been defined and noticed in the literature.

Objective
The aim of this study is to build a model using the convolutional neural network (CNN) to develop an app for automatic detection and classification of nurse BO using the Maslach Burnout Inventory–Human Services Survey (MBI-HSS) to help assess nurse BO at an earlier stage.

Methods
We recruited 1002 nurses working in a medical center in Taiwan to complete the Chinese version of the 20-item MBI-HSS in August 2016. The k-mean and CNN were used as unsupervised and supervised learnings for dividing nurses into two classes (n=531 and n=471 of suspicious BO+ and BO−, respectively) and building a BO predictive model to estimate 38 parameters. Data were separated into training and testing sets in a proportion 70%:30%, and the former was used to predict the latter. We calculated the sensitivity, specificity, and receiver operating characteristic curve (area under the curve) across studies for comparison. An app predicting respondent BO was developed involving the model’s 38 estimated parameters for a website assessment.

Results
We observed that (1) the 20-item model yields a higher accuracy rate (0.95) with an area under the curve of 0.97 (95% CI 0.94-0.95) based on the 1002 cases, (2) the scheme named matching personal response to adapt for the correct classification in model drives the prior model’s predictive accuracy at 100%, (3) the 700-case training set with 0.96 accuracy predicts the 302-case testing set reaching an accuracy of 0.91, and (4) an available MBI-HSS app for nurses predicting BO was successfully developed and demonstrated in this study.

Conclusions
The 20-item model with the 38 parameters estimated by using CNN for improving the accuracy of nurse BO has been particularly demonstrated in Excel (Microsoft Corp). An app developed for helping nurses to self-assess job BO at an early stage is required for application in the future.
Burnout, satisfacción y calidad de vida laboral en funcionarios de la salud pública chilenos
Authors: Salgado-Roa Jorge Alejandro , Leria-Dulčić Francisco Jose 
Published: December 2019

Introducción: Si bien se ha constatado la influencia negativa del síndrome de quemarse en el trabajo o Síndrome de Burnout (SB) en el desempeño laboral, aun los datos son elusivos respecto de su relación específica con la Satisfacción Laboral (SL) y Calidad de Vida Profesional (CVP) en el contexto de las profesiones asociadas a la salud pública. Objetivo: Analizar la asociación entre SB, SL y CVP, y algunas variables sociolaborales de 169 profesionales de la salud pública chilena. Materiales y métodos: Estrategia asociativa comparativa-transversal, aplicando el Inventario de Burnout de Maslach (MBI), la Escala de Satisfacción Laboral (S20/23), y el Cuestionario de Vida Profesional (CVP-35). Resultados: Un 10% de los trabajadores percibió altos niveles de SB, y una SL y CVP satisfactorias; un 88,8% medio/moderado. La edad cronológica, Motivación Intrínseca, Apoyo Directivo, estado civil y años de servicio explicaron el 33,5% de la variabilidad del Cansancio Emocional; y se plantean buenos predictores del SB. Conclusiones: Los datos reflejan una prevalencia media/moderada de SB, que puede ser entendida a la luz de la influencia insidiosa del síndrome. La edad cronológica y el estado civil se plantean como factores protectores. Se discuten los resultados en el contexto de la literatura existente.
The effect of ozone (O3) therapy in addition to high dose methylprednisolone on hypoxia inducible factor-1 alpha (HIF-1α) expression in rabbit cornea
Authors: ERTEKİN Yusuf Haydar , ARIKAN Sedat , KARABOGA İhsan 
Published: December 2019

Introduction: To investigate the effect
of ozone (O3) therapy on cornea subjected to systemically used high dose
methylprednisolone (MP) in a rabbit model.

Methods: Twenty-four New Zealand White adult male
rabbits were randomly divided into three equal groups as containing eight
animals. The first group (n = 8) was used as the control group and nothing was
applied to them, whereas the other 2 groups named as steroid groups were
subjected to IM methylprednisolone injection at a dose of 20 mg/kg/day for
three days. After three days of MP administration, only the third group was
treated with 50-µg/mL O3 (20 mL O3) through the rectal insufflation for 14
sessions. The histopathological examination of corneas of three groups were
made, and they were also assessed regarding the expression of hypoxia-inducible
factor-1 α (HIF-1α).

Results: It was determined that systemically
administered high dose MP caused erosion and necrosis in corneal epithelium and
stromal disintegrations in corneal stroma in steroid groups (Group 2 and Group
3). In the MP + O3 group (Group 3), the histopathological findings were mild.
The expression of HIF1-α in the cornea of Group1 (control group), Group 2 (MP),
and Group 3 (MP-O3) was measured as, 17.9±9.6%, 3.1±1.0% and 6.4±1.9% respectively.

Conclusions: MP and MP-O3 therapy decreased HIF-1a expression in rabbit cornea in
both intervention groups. Between these two groups, HIF-1α expression remained
relatively high in the MP-O3 group than in the MP group alone.
Prediction of perinatal complications of gestational diabetes
Authors: Rozhkova O. V. , Remneva O. V. , Trukhacheva N. V. 
Published: December 2019

Aim. To develop a tool for the prediction of perinatal complications in pregnant women with gestational diabetes utilizing conventional and ultrasound markers of diabetic fetopathy.Materials and Methods. We analyzed 128 case histories of women who suffered from gestational diabetes. Among their newborns, 35 had clinical manifestations of maternal hyperglycemia (birth weight > 90th percentile, neonatal hyperglycemia, respiratory distress syndrome, and neonatal jaundice) while 74 were free of the indicated signs and symptoms.Results. Risk factors of maternal hyperglycemia manifestations in neonates included family history of diabetes mellitus type 2, obesity, and pre-eclampsia. Maternal hyperglycemia was significantly associated with the higher risk of adverse perinatal outcomes. A combination of ≥ 4 ultrasound оценке markers of a diabetic fetopathy permitted the diagnosis of the fetal macrosomia. Conclusion. Ultrasound markers of diabetic fetopathy have limited sensitivity in the prediction of perinatal complications after gestational diabetes.
Clinicopathological parallelism in placental microbial colonization
Authors: Marochko T. Yu. , Levanova L. A. , Kolesnikova N. B. , Surina M. N. , Karelina O. B. , Kopytova K. R. 
Published: December 2019

Aim. To study the course of pregnancy, childbirth and the postpartum period in pregnant women with placental microbial colonization; to investigate placental morphology during the microbial colonization.Materials and Methods. We retrospectively investigated 128 case histories of the pregnant women with or without (n = 64) placental microbial colonization.Results. Enterobacteriaceae spp., Enterococcaceae spp. and Staphylococcaceae spp. were respectively isolated from placentas of 24 (37.5%), 19 (29.7%), and 19 (29.7%) women with placental microbial colonization. Candida albicans was isolated in 2 (3.1%) cases. All placentas excised from women without placental microbial colonization were sterile. Vaginal delivery occurred in 61 (95.3%) women with placental microbial colonization but only in 24 (37.5%) women without (p = 0.001). Subinvolution was revealed in 10 (15.6%) and 4 (6.3%) (р = 0.09), lochiometra was found in 4 (6.3%) and 2 (3.1%) (р = 0.409), and wound infections were observed in 5 (7.8%) and 1 (1.6%) (p = 0.095) women with or without placental microbial colonization, respectively. Therefore, prevalence of postpartum complications did not differ significantly between the groups. Placental inflammation was detected in 27(42.2%) and 14 (21.9%) (p = 0.014) patients with or without placental microbial colonization, respectively.Conclusions. Placental inflammation is associated with microbial colonization which is more common in women who undergo vaginal delivery.
Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns
Authors: Karelina O. B. , Artymuk N. V. , Tachkova O. A. , Marochko T. Yu. , Surina M. N. 
Published: December 2019

Aim: To study the level of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns.Materials and Methods. We consecutively recruited 40 pregnant women and their newborns. Blood sampling in pregnant women was carried out at the end of the third trimester 12 hours after the last meal while in newborns it was conducted immediately after birth. Measurement of serum thyroid-stimulating hormone, thyroxine, triiodothyronine, and free thyroxine was performed using chemiluminescent immunoassay.Results. Thyroid disease was significantly more common in pregnant women with obesity. Clinical and latent hypothyroidism in obese pregnant women was observed 1.5-fold more frequently as compared with those having normal body weight. In keeping with these findings, goiter and elevated thyroxine were also more common in obese pregnant women. Newborns from obese women were more often characterized by a transient hypothyroidism in combination with an augmented thyroid-stimulating hormone.Conclusion. Levels of thyroid-stimulating and thyroid hormones in obese pregnant women and their newborns significantly differ from the patients with normal body weight.
Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death
Authors: Golubenko M. V. , Tsepokina A. V. , Salakhov R. R. , Maksimov V. N. , Gurazheva A. A. , Tkhorenko B. A. , Ponasenko A. V. 
Published: December 2019

Aim.To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods.DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U, T and J) were determined using restriction fragment length polymorphism analysis. In addition, we performed a comparative analysis using previously published data on mtDNA polymorphisms in the West Siberian population.Results.The distribution of mtDNA haplogroups in the patients who died from sudden cardiac death was similar as in the general population: 40% for haplogroup H, 23% for haplogroup U, 12% for haplogroup T and 6.5% for haplogroup J. We found no significant differences regarding the frequency of mtDNA haplogroups in individuals who died from sudden cardiac death and the population level.Conclusion.We discovered no associations of H, U, T, and J mtDNA haplogroups with sudden cardiac death. These results indicate the necessity of a detailed analysis of mitochondrial genome to determine mtDNA variants associated with sudden cardiac death.
Adherence to immunoprevention: how to change the situation?
Authors: Briko N. I. , Mindlina A. Ya. , Galina N. P. , Korshunov V. A. , Polibin R. V. 
Published: December 2019

Aim. Immunoprevention represents a well-established tool to prevent and eliminate life-threatening infectious diseases. However, low adherence in the population is a major obstacle to achieve the full coverage of preventive vaccinations. Here we studied the adherence of various population groups and healthcare workers to vaccination.Materials and Methods. We conducted an original survey among 1147 university students, 214 parents and 512 physicians.Results. Among the students of humanitarian and technical faculties, only 33% and 37% respectively showed a positive attitude to immunoprevention. This indicator, however, was higher in medical students and physicians (76% and 80%, respectively). Overall awareness of all population groups on immunization is insufficient to perform such measures efficiently. The reasons of low adherence include anti-vaccine propaganda, negative attitude and lack of awareness of healthcare workers on immunoprevention efficiency.Conclusion. Further large efforts are urgently needed to increase the adherence to immunization both in general population and healthcare professionals. The primary task is to eliminate the lack of information on the role and importance of immunization in maintaining population health.
Valokuvan nainen
Authors: Schreck Hanna-Reetta 
Published: December 2019

Artikkeli tutkii kuvataiteilija Ellen Thesleffin (1869-1954) valokuvia ja niiden suhdetta hänen elämäänsä, aikakauteensa ja maalarin työhönsä. Tarkemman tarkastelun kohteeksi on valikoitunut seitsemän omavalokuvaa Thesleffistä noin 1890-luvun alusta. Lisäksi artikkelissa rinnastetaan Thesleffin valokuvia hänen vuosina 1894-95 maalaamaansa Omakuvaan sekä siitä otettuun valokuvaan.

Kuvien Ellen Thesleff ilmentää koko ruumiillaan, valokuvallisella olemassaolollaan, jotakin erityistä. Kuvissa esiintyy kapinallinen nainen, joka katsoo suoraan kohti, myös kameraan ja hänellä on lyhyet hiukset. Tutkija Juliet McMasterin mukaan naisten kajoaminen omiin hiuksiinsa oli ”feminiininen itsenäisyydenjulistus”, koska saksia käyttävä henkilö oli nainen itse. Taiteilijan sukupuolipiirteitä liudentavan olemuksen voi lukea 1800-luvun asenneilmastossa itsevarmuutena, joka pohjautui oman kyvykkyyden tiedostamiseen ja sen korostamiseen. Queer-teoreetikko Judith Halberstamin (Female Masculinity 1998) mukaan maskuliinisuus ei palaudu vain miehen kehoon, vaan maskuliinisuutta tekevät myös naiset – se määrittyy toiminnan, asennoitumisen ja itseilmaisun kautta.

Thesleffin omavalokuvien avulla voimme tutkia, miten hän otti osaa modernin naissubjektin synnyttämiseen ja siihen liittyviin keskusteluihin, ja eli modernia ruumiillisuutta. Thesleffin omavalokuvia on mahdollista lähestyä vapauttavina ja demokratisoivina kuvina. Hänen omissa verkostoissaan nämä valokuvat saattoivat toimia emansipoivasti, tuoden niin Thesleffille kuin hänen lähipiirilleen uusia kuvia ja käsityksiä siitä, mitä ruumiillisuus, sukupuoli ja toimijuus oli ja voisi olla.
NUTRITIONAL STATUS AND SELF-REPORTED NUTRITION EDUCATION EXPOSURE IN WOMEN WITH GESTATIONAL DIABETES MELLITUS AT PRIMARY HEALTH CLINIC
Authors: Samiun Nurul Alia Aqilah , Mohd Yusof Barakatun Nisak , Ismail Irmi Zarina , Anuar Farhanah , Chee Winnie Siew Swee 
Published: December 2019

Background: Optimal nutritional status is of utmost importance not only for foetal development but also to maintain normoglycemia in women with gestational diabetes mellitus (GDM). This cross-sectional study described the nutritional status of women with GDM and explored whether self-reported nutrition education (NEd) exposure before a GDM diagnosis would be able to promote better nutrition status.
Methods: GDM women (n= 60; age= 31.6 ± 5.0 years) diagnosed between 13th and 28th week of gestation participated in the study. We assessed nutritional status that included anthropometric and blood pressure assessments, biochemical data, and dietary intake. The respondents self-reported their NEd exposure before a GDM diagnosis was made.
Results: The pre-pregnancy BMI of the participants was 27.9 ± 6.8 kg/m2, which was categorised as overweight. Total (4.3 ± 5.6 kg) and rate (0.2 ± 0.3 kg/week) of gestational weight gain were within the recommendations. Glycemic parameters and blood pressure were also within the normal range. Nevertheless, they had high intakes of fat (35.5%) and sugar (14.4%) proportionate to their energy intake. They did not meet the recommended nutrient intakes for fibre, calcium, and iron. Only 28.3% of women had prior NEd exposure. Among them, almost all (94.1%) had recurrent GDM. Those with NEd exposure had lower pre-prandial blood glucose profiles, systolic blood pressure, and proportion of protein intake from energy than those without (p< 0.05).
Conclusion: Suboptimal maternal nutritional status and low exposure to NEd are evident in women with GDM. Those with self-reported NEd exposure had better parameters of nutritional status. The findings recognised the need of having proper nutrition education for women who are at high risk of GDM since at early pregnancy.
Penerapan Program Pengembangan Kewirausahaan Pada Mahasiswa (Tenant) di Universitas Kanjuruhan Malang
Authors: Budianto Alexius Endy , Dianawati Eris , Iswahyudi Didik 
Published: December 2019

The implementation of the Entrepreneurship Development Program (PPK) at Kanjuruhan University in Malang is expected to achieve the objectives of: (1) creating start-ups and independent new entrepreneurs, (2) improving business management skills for industrial communities, (3) creating entrepreneurship training methods suitable for students , (4) business units that can generate profit as a source of generating revenue from Kanjuruhan Malang University, and (5) opening or providing employment. The stages in implementing PPK include: (1) Dissemination of the PPK program, this socialization is carried out through announcements on campus boards, campus websites, and social media (Student groups and Alumni Groups). (2) Participants register before they enter the PPK tenant. (3) Following a written test to see the scientific potential possessed about the world of entrepreneurship, followed by interviews to find out the motivation and seriousness of participants in the PPK program. (4) The results of the selection will determine 20 best value people as prospective tenants. (5) Participants must fill out the willingness sheet to complete the PPK program to completion. Whereas specifically to be achieved are: soul growth and entrepreneurial culture on campus, increased ability to prepare business plans, development of products that have been produced by tenants after participating in PPK activities, the creation of innovative and renewable products. The program will be implemented in a participatory manner with knowledge transfer methods from the proposing team, business experts, UMKM players to PPK tenants through education and training, business simulations, internships, intensive assistance, preparing business plans, and applying business to the tenants' potential and talents.
KELOMPOK PENDAMPING STIMULASI PRODUKSI ASI (KP-STIPASI) BERBASIS COMMUNITY SUPPORT DI KELURAHAN KARANGROTO SEMARANG
Authors: Wuriningsih Apriliani Yulianti , Khasanah Nopi Nur , Puspita Sari Dyah Wiji 
Published: December 2019

Air susu ibu (ASI) merupakan nutrisi terbaik untuk kesehatan bayi. World Health Organisation (WHO) dan United Nations Children’s Fund(UNICEF) merekomendasikan pelaksanaan inisiasi menyusui dini (IMD), pemberian ASI eksklusif selama 6 bulan pertama kehidupan, dan terus menyusui sampai usia 24 bulan sebagai strategi penting untuk mengurangi kematian bayi, khususnya di negara berkembang. Tujuan kegiatan Kelompok Pendamping Stimulasi Produksi ASI (KP-STIPASI), yaitu meningkatkan pemahaman, kesadaran, dan keterampilan ibu hamil di Kelurahan Karangroto untuk mempersiapkan proses menyusui dan ASI eksklusif. Metode pelaksanaan terdiri dari sosialisasi, peningkatan kompetensi, latihan ketrampilan, monitoring dan evaluasi. Hasil kegiatan menunjukkan bahwa terbentuknya forum diskusi kader kesehatan dengan fokus kegiatan pada ibu hamil untuk mempersiapkan proses menyusui di bawah binaan Puskesmas Bangetayu, meningkatnya kemampuan dan ketrampilan kader kesehatan dalam menstimulasi produksi ASI dari 25% menjadi 87%, meningkatkan prenatal breastfeeding self efficacydari 35% menjadi 85%. KP-STIPASI berbasis community supportmenjadi strategi yang tepat untuk memberdayakan masyarakat dalam meningkatkan kesiapandan keyakinan ibu hamil untuk menyusui eksklusif (prenatal breastfeeding self efficacy). Kegiatan PKM selanjutnya diharapkan dapat mengembangakan KP-STIPASI berbasis community supportdi seluruh RW Kelurahan Karangroto. Kegiatan tidak hanya berfokus pada ibu hamil, namun juga pada ibu yang memiliki anak berusia di bawah dua tahun (baduta) dan ibu menyusui.