bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentials of big data for corporate environmental management: A case study from the German automotive industry
Authors: Beier Grischa , Kiefer Julian , Knopf Jutta 
Published: September 2020

AbstractIntegrating more sustainability into business processes is becoming increasingly important for companies. At the same time, they aim to collect and analyze large amounts of data (big data) to improve these processes. The potentials of big data for corporate environmental protection are hardly dealt with in the scientific literature. The main contribution of this paper is to identify potential big data use cases for corporate environmental management by using the example of the German automotive industry. For this purpose, expert interviews were conducted with corporate environmental managers which were evaluated by using a qualitative content analysis. In order to balance this environmental perspective and enhance it with data analytical expertise, these use cases were assessed by data analytics experts through a mixed method approach, in a subsequent process. The presentation of the identified five use cases and their critical reflection through data analytics experts are the key results of this paper.
Capital Bubbles, Interest Rates, and Investment in a Small Open Economy
Authors: KIKUCHI TOMOO , THEPMONGKOL ATHAKRIT 
Published: September 2020

AbstractWe model a bubble in a productive asset (capital) on an explosive path, which diverges from the fundamental equilibrium and bursts with a positive probability. When the bubble grows, the small open economy borrows from the the world economy to finance investment and production, and banks charge the risk of the bubble bursting as an interest rate spread to debtors. Consequently, the interest rate spread widens as loans are increasingly backed by the bubble. When the bubble bursts, defaults cause a sudden stop of credit inflow from the world economy, investment falls, and the interest rate spread vanishes.
Recent advances in gene therapy for neurodevelopmental disorders with epilepsy
Authors: Turner Thomas J. , Zourray Clara , Schorge Stephanie , Lignani Gabriele 
Published: September 2020

AbstractNeurodevelopmental disorders can be caused by mutations in neuronal genes fundamental to brain development. These disorders have severe symptoms ranging from intellectually disability, social and cognitive impairments, and a subset are strongly linked with epilepsy. In this review, we focus on those neurodevelopmental disorders that are frequently characterized by the presence of epilepsy (NDD + E). We loosely group the genes linked to NDD + E with different neuronal functions: transcriptional regulation, intrinsic excitability and synaptic transmission. All these genes have in common a pivotal role in defining the brain architecture and function during early development, and when their function is altered, symptoms can present in the first stages of human life. The relationship with epilepsy is complex. In some NDD + E, epilepsy is a comorbidity and in others seizures appear to be the main cause of the pathology, suggesting that either structural changes (NDD) or neuronal communication (E) can lead to these disorders. Furthermore, grouping the genes that cause NDD + E, we review the uses and limitations of current models of the different disorders, and how different gene therapy strategies are being developed to treat them. We highlight where gene replacement may not be a treatment option, and where innovative therapeutic tools, such as CRISPR‐based gene editing, and new avenues of delivery are required. In general this group of genetically defined disorders, supported increasing knowledge of the mechanisms leading to neurological dysfunction serve as an excellent collection for illustrating the translational potential of gene therapy, including newly emerging tools.image
Setting the Tone for the Team: A Multi‐Level Analysis of Managerial Control, Peer Control, and their Consequences for Job Satisfaction and Team Performance
Authors: Walter Jorge , Kreutzer Markus , Kreutzer Karin 
Published: September 2020

AbstractIn this study, we develop a multi‐level theoretical framework linking antecedents and outcomes of peer control, defined as team members at the same hierarchical level noticing and responding to their peers’ behaviour or performance. Analysing multi‐level data from 356 volunteers and 58 regional teams in a non‐profit organization, we examine top‐down managerial controls as antecedents of lateral peer control, both directly (i.e., monitoring and responding directly to peers) and indirectly (i.e., gossiping about and avoiding underperforming peers), and peer control’s effects on individual‐ and team‐level outcomes. In line with our predictions, we find formal managerial control and clan control to be antecedents of peer control, albeit with differential effects on direct and indirect peer control. We also find a significant association between peer control and both individual‐level job satisfaction and team‐level performance, but again, with crucial differences between the two types of peer controls and the two outcomes. Our study contributes to the development of a better theoretical understanding of peer control, sheds light on inconsistent findings across prior studies, provides novel insights into how team leaders can influence team members’ individual satisfaction and team‐level performance via peer control, and reveals important trade‐offs with regards to peer control’s influence on individual‐ and team‐level outcomes.
Insights of Brazilian consumers' behavior for different coffee presentations: An exploratory study comparing hard laddering and completion task
Authors: Sales Yasmin Janaína D. , Corrêa Fernando J. Braz , Tavares‐Filho Elson R. , Soares Paula Thaís S. , Durço Bruna B. , Pagani Mônica M. , Freitas Mônica Q. , Cruz Adriano G. , Esmerino Erick A. 
Published: September 2020

AbstractCoffee is one of the most appreciated beverages worldwide. However, little is known about the factors that motivate the consumption of coffee in the form of capsules (CC), roasted beans (CB), and powder (CP). Thus, qualitative methodologies such as of completion task (CT) and hard laddering (HL) were used in this study to help understand the motivations that drive the choice of different coffee presentations. The results obtained show that CP was perceived as traditional, practical, low cost, low quality generating less pleasure during consumption when compared with the others. CC was perceived as more practical, with the practicality and variety of flavors, although the higher price, lower sensory quality and the environmental impacts were relevant perceptions. Although CB was perceived as a high‐quality product, generating greater consumer satisfaction, its high cost and lack of convenience stood out. Therefore, both techniques were able to capture the consumers' perception with great similarity between the results; however, it is worth emphasizing that HL was able to achieve deeper values related to food choice and consumption of product. This information can be used by the coffee producers and the processing industries to develop effective marketing strategies to effectively reach market segments.Practical applicationAs the demand for coffee consumption has increased over the years, driven by the diversification of commercial presentations of the product, it is of great value to understand the perception of consumers and the factors involved in purchase and consumption. Laddering is a useful in‐depth interviewing technique of qualitative research that unveils opinions, attitudes and beliefs that are part of consumers' cognitive structure. Projective methodologies as completion task use ambiguous and indirect stimuli such as images or stories encourage participants to project their own experience onto the stimuli, allowing that values, ideas, and abstract need to be explored. We believe that the data obtained in such a deep and spontaneous way can be extrapolated to guide actions and can help several decisions of product development, labeling, packaging, and marketing.
Community‐level burden of acute diarrhoeal illness in the first 2 years of life in Brisbane, Australia: A birth cohort study
Authors: Mihala Gabor , Grimwood Keith , Lambert Stephen B , Ware Robert S 
Published: September 2020

AimThis study sought to describe the burden of acute diarrhoeal illness (ADI) in an Australian subtropical urban setting following rotavirus vaccine introduction and to investigate the associations between child/family characteristics and ADI.MethodsParents of 154 children from the Observational Research in Childhood Infectious Diseases birth cohort provided daily symptom and health‐care data until the age of 2 years.ResultsThe incidence rate of ADI was 1.07 per child‐year (95% confidence interval: 0.94–1.21). The median length of episode duration was 3 days (25th–75th percentiles: 1–6). The incidence rate was significantly higher in the first month of life and between 6 and 17 months of age compared with 18–23 months, also for children with siblings and in formal childcare. Overall, 49% of ADI episodes led to health‐care visits.ConclusionsDespite a successful rotavirus vaccine programme, ADI still results in a substantial disease burden affecting young Australian children and their families.
Mycorrhizal fungi maintain plant community stability by mitigating the negative effects of nitrogen deposition on subordinate species in Central Asia
Authors: Jia Yangyang , Walder Florian , Wagg Cameron , Feng Gu 
Published: September 2020

AbstractQuestionsPlant community stability is threatened by increasing numbers of simultaneously changing factors such as increased precipitation and nitrogen (N) deposition. Despite the pivotal roles of arbuscular mycorrhizal fungi (AMF) for plant community dynamics, only few studies have paid attention to their roles in maintaining plant community stability under global change. We therefore assessed the interactive effects of a realistic N deposition and AMF on plant community temporal stability under future increased precipitation scenarios.LocationGurbantunggut desert, China.MethodsWe conducted a four‐year field experiment simulating a realistic N deposition and with/without AMF treatments in one typical ephemeral plant community, dynamically monitoring the changes in plant community biomass and composition.ResultsWe found that suppression of AMF significantly reduced Shannon–Wiener diversity and evenness while the realistic N deposition only marginally reduced the Shannon–Wiener diversity. Suppression of AMF and increased N deposition highly increased the species turnover. Particularly, the stability of subordinate plant species significantly correlated to the community‐level stability. AMF were able to buffer the negative effects of increased N deposition on plant community diversity, to maintain community‐level stability.ConclusionsOur study supports the subordinate insurance hypothesis, highlighting the considerable roles of subordinate plant species in maintaining community stability. Furthermore, our results indicate the joint roles of AMF and N deposition in regulating plant community stability, and point to the importance of taking AMF and the realistic N deposition into account for understanding the responses of community stability to multiple global change scenarios.
Contrasting signatures of introgression in North American box turtle (Terrapene spp.) contact zones
Authors: Martin Bradley T. , Douglas Marlis R. , Chafin Tyler K. , Placyk John S. , Birkhead Roger D. , Phillips Christopher A. , Douglas Michael E. 
Published: September 2020

AbstractHybridization occurs differentially across the genome in a balancing act between selection and migration. With the unprecedented resolution of contemporary sequencing technologies, selection and migration can now be effectively quantified such that researchers can identify genetic elements involved in introgression. Furthermore, genomic patterns can now be associated with ecologically relevant phenotypes, given availability of annotated reference genomes. We do so in North American box turtles (Terrapene) by deciphering how selection affects hybrid zones at the interface of species boundaries and identifying genetic regions potentially under selection that may relate to thermal adaptations. Such genes may impact physiological pathways involved in temperature‐dependent sex determination, immune system functioning and hypoxia tolerance. We contrasted these patterns across inter‐ and intraspecific hybrid zones that differ temporally and biogeographically. We demonstrate hybridization is broadly apparent in Terrapene, but with observed genomic cline patterns corresponding to species boundaries at loci potentially associated with thermal adaptation. These loci display signatures of directional introgression within intraspecific boundaries, despite a genome‐wide selective trend against intergrades. In contrast, outlier loci for interspecific comparisons exhibited evidence of being under selection against hybrids. Importantly, adaptations coinciding with species boundaries in Terrapene overlap with climatic boundaries and highlight the vulnerability of these terrestrial ectotherms to anthropogenic pressures.
The technological challenges of reducing the saturated fat content of foods
Authors: Bruce J. H. 
Published: September 2020

AbstractIndustrial food scientists modify oil formulations in order to meet their customers’ needs such as cost and nutritional content, but the fat formulae must also function during production of the food and in the finished food product. Unlike mono‐ and polyunsaturated fatty acids, saturated fatty acids (SFA) are resistant to oxidation and become solid at room temperatures. Reducing the level of SFA therefore creates technical difficulties. Techniques such as plant breeding to reduce polyunsaturated fat and so increase oxidative stability, and fractionation and interesterification to provide greater firmness, are discussed. Opportunities for SFA reduction are identified in baked goods, such as biscuits, cakes and pastries, using formulations which are already available on the market. Other products, such as meat, dairy and confectionery, would prove harder to reformulate. An example of a successful change in fatty acid profiles of foods is the removal of industrially produced trans fatty acids, which was largely complete in the UK by 2006. Similar methods could be used to bring about a reduction in intake of saturated fat, but the food industry would need compelling scientific, regulatory or public relations arguments to motivate these changes due to the costs involved.
Toward pollen sterility in German chamomile (Matricaria chamomilla)–Conventional breeding approaches of cytoplasmic/genic male sterility and chemical emasculation
Authors: Faehnrich Bettina , Huber Julia , Wagner Sarah , Franz Chlodwig , Fraust Beate , Wehrle Maria , Ruzicka Joana , Novak Johannes , Otto Lars‐Gernot 
Published: September 2020

AbstractPollen sterility (PS) in mother lines is crucial for hybrid crossings in plant breeding. 21 di‐ (2x) and tetraploid (4x) accessions of the hermaphroditic chamomile were screened for spontaneous, thermic or gametocide induced PS. Two crossing trials with the diploid accessions 'Bona' (BON) and 'Hungary 2' (HUN2) should specify maternally inherited cytoplasmic male sterility (CMS). Progeny thereof showed increased PS. BON as mother (BH) entailed means of 30 and 22% PS, versus 8% and 20% after reciprocal crossings. Backcrosses of BH with HUN2 in paternal and maternal direction revealed increasing mean PS (24% and 32%), without verification of CMS. A split plot design of 100 individuals treated with four chemical gametocides analyzed PS, seed set, germination rate and whole plant damage. Tri‐iodobenzoic acid caused the highest PS (43%). Progeny of two plants (2x, 4x) with degenerated anthers without pollen, showed 100% PS either in tetraploid F1 and F2 (4% and 11%) or in diploid F2 and F3 (26% and 23%). High temperature (30/28°C day/night) decreased the male fertility to some extent.
Trichomonas vaginalis‐secreted cysteinyl leukotrienes promote migration, degranulation and MCP‐1 production in mast cells
Authors: Lee Young Ah , Nam Young Hee , Min Arim , Shin Myeong Heon 
Published: September 2020

AbstractTrichomonas vaginalis, a flagellated extracellular protozoan parasite that infects the human genitourinary tract, is usually transmitted by sexual contact. Our previous study showed that the leukotriene B4 (LTB4), a T vaginalis‐secreted lipid mediator, induces interleukin (IL)‐8 production and promotes mast cell degranulation and migration via BLT1 in human. In this study, we investigated whether T vaginalis produces another leukotrienes and whether it causes increased MCP‐1 production, mast cell migration and degranulation by activating mast cells. We found that cysteinyl leukotrienes (CysLTs) were contained in T vaginalis‐derived secretory product (TvSP) by ELISA. The TvSP‐stimulated human mast cell line (HMC‐1) exhibited significantly increased monocyte chemoattractant protein‐1 (MCP‐1) secretion compared to the unstimulated cells. Inhibition of NOX2 activation of cells by treatment of NOX inhibitor or NOX2 siRNA reduced TvSP‐stimulated MCP‐1 production in HMC‐1 cells. It was also confirmed that the receptor for CysLTs is expressed in mast cells. The CysLT receptor (CysLTR) antagonist inhibited TvSP‐stimulated MCP‐1 production of mast cells, as well as ROS production, migration and degranulation of mast cells, and reduced phospho‐NF‐kB expression. These results suggest that T vaginalis‐secreted CysLTs promote migration, degranulation and MCP‐1 production in human mast cells through CysLT receptor‐mediated NOX2 activation.
Co‐occurrence of EBV‐positive classic Hodgkin lymphoma and B‐cell lymphomas of different clonal origins: A case report and literature review
Authors: Karube Kennosuke , Takatori Mitsuyoshi , Kohno Kei , Tomoyose Takeaki , Ohshiro Kazuiku , Nakazato Iwao 
Published: September 2020

AbstractAlthough cases with metachronous or synchronous co‐occurrence of classic Hodgkin lymphoma (CHL) and B‐cell non‐Hodgkin lymphoma (B‐NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein–Barr virus (EBV)‐positive settings. Here, we report a case of a 38‐year‐old male with CHL, followed by the recurrence of EBV‐positive mucocutaneous ulcers of the large intestine and EBV‐positive diffuse large B‐cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co‐occurrence of CHL and B‐NHL in EBV‐positive settings. In contrast to EBV‐negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B‐cells could simultaneously proliferate in EBV‐associated settings, providing a new insight into the pathogenesis of EBV‐associated lymphoproliferative disorders.
Investigation of Mechanical Integrity of Prismatic Lithium-Ion Batteries With Various State of Charge
Authors: Wang Tao , Chen Xiaoping , Chen Gang , Ji Hongbo , Li Ling , Yuan Quan , Liu Yuezhuan , Ji Yingping 
Published: September 2020

Abstract
The crush safety of lithium-ion batteries (LIBs) has recently become one of the hottest topics as the electric vehicle (EV) market is growing rapidly. In this study, mechanical properties of prismatic lithium-ion batteries under compression loading are investigated. Batteries with different values of state of charge (SOC) under different loading directions are compared. Results show LIB cells with different SOCs under same loading direction exhibit similar response curve profile, however, the load capacities of LIBs can be influenced by SOCs. The stiffness and stress have approximately linear relationship with the SOC values. Based on experimental results, finite element models are established which can predict the mechanical properties of prismatic LIBs. The proposed models can be utilized to evaluate the crush behaviors of LIBs, providing guidance for electric vehicle safety design.
Protocol of a randomised controlled phase II clinical trial investigating PREoperative endoscopic injection of BOTulinum toxin into the sphincter of Oddi to reduce postoperative pancreatic fistula after distal pancreatectomy: the PREBOTPilot trial
Authors: Klaiber Ulla , Sauer Peter , Martin Eike , Bruckner Thomas , Luntz Steffen , Tjaden Christine , Probst Pascal , Knebel Phillip , Diener Markus K , Buchler Markus W , Hackert Thilo 
Published: September 2020

IntroductionPostoperative pancreatic fistula (POPF) is still the most frequently occurring and clinically relevant complication after distal pancreatectomy (DP). Preoperative endoscopic injection of botulinum toxin (BTX) into the sphincter of Oddi represents an innovative approach to prevent POPF. The aim of this project (PREBOTPilot) is to generate the first randomised controlled trial data on the safety, feasibility and efficacy of preoperative endoscopic BTX injection into the sphincter of Oddi to prevent clinically relevant POPF following DP.Methods and analysisPREBOTPilot is an investigator-initiated, single-centre, randomised, controlled, open-label, phase II clinical trial with two parallel study groups and an exploratory study design. 60 patients scheduled for DP will be randomised to intervention and control group. In the intervention group, patients will undergo preoperative endoscopic injection of BTX into the sphincter of Oddi, whereas in the control group no preoperative endoscopy will be performed. The combined primary endpoint is the occurrence of clinically relevant POPF and/or death within 30 days after DP. The secondary endpoints comprise further postoperative outcome parameters and quality of life up to 3 months after DP as well as safety and feasibility of the procedure. Statistical analysis is based on the modified intention-to-treat population, excluding patients without status post DP. For safety analysis, rates of adverse events (AEs) and serious AEs will be calculated with 95% CIs for group comparisons.Ethics, funding and disseminationPREBOTPilot has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4043654) and the Ethics Committee of Heidelberg University (reference number AFmo-523/2019). This trial is supported by the German Federal Ministry of Education and Research (BMBF). The results of the trial will be presented at national and international conferences and published in a peer-reviewed journal.Trial registration numberDRKS00020401.