bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF 8 WEEK RESISTANCE EXERCISES ON BLOOD LIPIDS AND BLOOD SUGAR LEVELS IN SEDENTARY WOMEN
Authors: Turgut M , Bağır S , Bozkuş T , Talaghir L , Sarıkaya M 
Published: November 2019

Aim. The purpose of this study was to investigate the effects of an eight-week resistance exercise program on blood fats and blood sugar in sedentary women. The study included 20 volunteers with a mean age of 31.70 ± 3.81 years. Materials and methods. Blood samples were taken by the experts in the appropriate laboratory environment in the morning before and after the resistance exercise program, which was administered 60 minutes 3 days a week for 8 weeks in the mornings on an empty stomach. Dependent groups t-test (Paired Sample T-Test) was applied to compare descriptive statistics with pre- and post-exercise values by using SPSS 22.0 package program. Results. There was a significant difference between GLU, Triglyceride, HDL, LDL, and total cholesterol levels before and after the resistance exercise program (p > 0.05). Conclusions. Resistance exercises have a positive effect on blood sugar and blood fat change. Therefore, we think that it can be used as protection from cardiovascular diseases, and if these exercises are applied regularly, they will have many positive results in terms of health.
FACTOR PROFILES OF FUNCTIONAL AND TECHNICAL FITNESS IN NORDIC COMBINED SKIERS DURING MULTIYEAR PREPARATION
Authors: Zebzeev V , Zekrin F , Zdanovich O 
Published: November 2019

Aim. The article deals with establishing the differences in the functional and technical fitness of Nordic combined skiers during multiyear preparation. Material and methods. To establish the factor profiles of the functional and technical fitness in Nordic combined skiers, we examined athletes at different stages of multiyear preparation: 40 athletes – initial preparation, 35 athletes – 2-year training program, 40 athletes – more than 2-year training program, 30 athletes – sports performance enhancement. The structure of functional and technical fitness was established with the help of factor analysis. Results. The comparative analysis of the factor structure of functional and technical fitness in Nordic combined skiers revealed the significant differences at each stage of multiyear training. It was established that during the stage of initial preparation and 2-year training program the most important factors are the nervous system (eye-hand visual reaction time, reaction to a moving object, interference resistance) and jumping fitness (angle characteristics during the run-up, take-off, flight, and landing), which create favorable conditions for forming the basics of ski-jumping technique in Nordic combined skiers. After 2-year training program and at the stage of performance enhancement the leading factors of physical fitness are determined by the cardiovascular (the Ruffier test, recovery constant, and Health integral indicator) and respiratory (VO2max, the Shtange's and Hench's breath test) systems, as well as ski racing technique (angle characteristics at different phases), which are favorable for the enhancement of ski racing technique. Conclusions. The results obtained allow the coaches to effectively improve functional and technical fitness and adjust training loads to the specifics of a certain stage of multiyear training.
Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?
Authors: LaPointe Paul , Mercier Rebecca , Wolmarans Annemarie 
Published: November 2019

Abstract
Heat shock protein 90 (Hsp90) is a dimeric molecular chaperone that plays an essential role in cellular homeostasis. It functions in the context of a structurally dynamic ATP-dependent cycle to promote conformational changes in its clientele to aid stability, maturation, and activation. The client activation cycle is tightly regulated by a cohort of co-chaperone proteins that display specific binding preferences for certain conformations of Hsp90, guiding Hsp90 through its functional ATPase cycle. Aha-type co-chaperones are well-known to robustly stimulate the ATPase activity of Hsp90 but other roles in regulating the functional cycle are being revealed. In this review, we summarize the work done on the Aha-type co-chaperones since the 1990s and highlight recent discoveries with respect to the complexity of Hsp90 cycle regulation.
Developments in anticancer vaccination: budding new adjuvants
Authors: Santos-Sierra Sandra 
Published: November 2019

Abstract
The immune system has a limited capacity to recognize and fight cells that become cancerous and in cancer patients, the immune system has to seek the right balance between cancer rejection and host-immunosupression. The tumor milieu builds a protective shell and tumor cells rapidly accumulate mutations that promote antigen variability and immune-escape. Therapeutic vaccination of cancer is a promising strategy the success of which depends on a powerful activation of the cells of the adaptive immune system specific for tumor-cell detection and killing (e.g. CD4+ and CD8+ T-cells). In the last decades, the search for novel adjuvants that enhance dendritic cell (DC) function and their ability to prime T-cells has flourished and some Toll-like receptor (TLR) agonists have long been known to be valid immune adjuvants. The implementation of TLR-synthetic agonists in clinical studies of cancer vaccination is replacing the initial use of microbial-derived products with some encouraging results. The purpose of this review is to summarize the latest discoveries of TLR-synthetic agonists with adjuvant potential in anti-cancer vaccination.
Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
Authors: Colak Ulkem , Mutlu Gul Y. , Sozmen Banu O. , Yucel Esra B. , Kayserili Hulya , Hatun Sukru 
Published: November 2019

Abstract
Malignancy-induced hypercalcemia is a very rare condition in children whereas it is more common among adult patients with malignancy. The mechanisms of malignancy-induced hypercalcemia include the over-secretion of parathyroid hormone-related protein (PTHrP), osteolytic metastases and the over-production of 1,25-dihydroxyvitamin D (calcitriol). Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases. Herein, we report calcitriol-mediated severe hypercalcemia in a 5-year-old boy with squamous cell skin carcinoma arising in the background of xeroderma pigmentosum (XP) which responded well to zoledronate treatment. To the best of our knowledge, this is the first pediatric case of malignancy-induced hypercalcemia which is mediated by calcitriol in squamous cell skin carcinoma.
Ground state chemistry under vibrational strong coupling: dependence of thermodynamic parameters on the Rabi splitting energy
Authors: Thomas Anoop , Jayachandran Anjali , Lethuillier-Karl Lucas , Vergauwe Robrecht M.A. , Nagarajan Kalaivanan , Devaux Eloise , Genet Cyriaque , Moran Joseph , Ebbesen Thomas W. 
Published: November 2019

Abstract
Vibrational strong coupling (VSC) is currently emerging as a tool to control chemical dynamics. Here we study the impact of strong coupling strength, given by the Rabi splitting energy (ħΩR), on the thermodynamic parameters associated with the transition state of the desilylation reaction of the model molecule 1-phenyl-2-trimethylsilylacetylene. Under VSC, the enthalpy and entropy of activation determined from the temperature-dependent kinetic studies varied nonlinearly with the coupling strength. The thermodynamic parameters of the noncavity reaction did not show noticeable variation, ruling out concentration effects other than the enhanced ħΩR for the changes observed under VSC. The difference between the total free energy change under VSC and in noncavity was relatively smaller possibly because the enthalpy and entropy of activation compensate each other. This thermodynamic study gives more insight into the role of collective strong coupling on the transition state that leads to modified dynamics and branching ratios.
High Temperature Permanent Magnet Synchronous Machine Analysis of Thermal Field
Authors: Komeza Krzysztof , Lefik Marcin , Roger Daniel , Juszczak Ewa Napieralska , Elmadah Hamed , Napieralski Piotr , Takorabet Noureddine 
Published: November 2019

Abstract
The subject of the paper is a three-dimensional analysis of a coupled fluid-thermal and electromagnetic field in permanent magnet synchronous machine that can work at very high temperatures. To obtain the distribution of the airflow and temperature we employed the coupled fluid-thermal model of the machine. This allowed us to check whether the temperature in sensitive elements does not exceed the permissible limits. The analysis took into account the effect of the color and the smoothness of the machine housing on the temperature distribution in its interior. The influence of design on the temperature distribution and distribution of hot spots was tested. Two topologies are studied considering magnet mounted on the rotor surface or buried in the rotor soft magnetic core. The simulation results were compared with measurements made on a prototype.
Evaluation of the clinical chemistry tests analytical performance by using different models and specifications
Authors: Keleş Murat 
Published: November 2019

Abstract

Background
The importance of managing analytical quality in clinical laboratories is known. Goal-setting models are critical for analytical quality management, along with correctly implemented error models. However, the methods used to determine analytical performance and more importantly, the relevant analytical quality goals are open to discussion. Our aim was to compare the analytical performance characteristics of routine clinical chemistry tests with different goal-setting models which was proposed by various establishments. In addition, to provide a perspective to Turkish total analytical error (TAE) circular letter that compulsory to calculate from 2016.

Materials and methods
This study was performed by the data obtained from the internal and external quality control of clinical chemistry tests which were measured by Roche Cobas c501 biochemistry analyzer. TAE calculated with TAE% = 1.65 ×(CV%) + Bias% formula. Nordtest uncertainty model was used in the calculation of measurement uncertainty (MU). In this context, total analytical error was evaluated with biological variation (BV), RCPA, CLIA and Turkish allowable total error (ATE) goals. Measurement uncertainty was evaluated with only permissible measurement uncertainty (pU%) goal.

Results
In our study, RCPA goals are the most stringent, followed by the BVEuBIVAS, BVRicos, pU%, CLIA and finally the ATETurkey goals coming in last. In cumulatively, BVEuBIVAS goals were 18.3% lower than BVRicos for evaluated parameters.

Conclusion
The balance between applicability and analytical assurance of goals should be well ensured when determining goal-setting models. Circular letter (2016/18) creates awareness to the analytical quality management but still open to development. Biological variation dependent total allowable error model never designed to be used as benchmarks for measurement uncertainty and it is not methodologically appropriate for assessing measurement uncertainty which was estimated by the Nordtest method. Also considered that, the use of “permissible MU” is more methodologically appropriate in the evaluation of measurement uncertainty.
Metaheuristics Optimized Machine Learning Modelling of Environmental Exergo-Emissions for an Aero-Engine
Authors: Baklacioglu Tolga , Turan Onder , Aydin Hakan 
Published: November 2019

Abstract
The purpose of this study is to develop a metaheuristic design for primary parameters and architectures of two models of artificial neural network (ANN) in predicting a cargo aircraft’s exergo-emissions (exergy destruction ratio, rex,dest
, and waste exergy ratio, rwex
) at different flight stages. Hybrid genetic algorithm (GA)-ANN models have been accomplished utilizing real databases of rex,dest
and rwex
at various powers. Implementing a metaheuristics-based optimization on multilayer perceptron (MLP)-ANNs has produced the most favourable initial weights, step-size, biases, and training algorithm’s back-propagation (BP) momentum rate in addition to optimum number of neurons in the hidden layer(s). In accordance with an error assessment, a close fit linking real data and rwex
(linear correlation ratio, R, value of 0.999851) as well as rex,dest
(R value of 0.999985) predicted values is found. In the rex, dest
estimation model, the accuracy among single-hidden-layer networks has been confirmed to be higher; whereas, highly accurate testing outcomes have been obtained in two-hidden-layer networks as far as modeling of rwex
is concerned. ANN models’ optimization by GAs has increased the accuracy of the resulting models (R value of 0.999987 and 0.999869 for rex,dest
and rwex
, in that order ascertaining a drop-off in the testing stage errors).
JINĀS DALAM KITAB FATHUL MU’IN KARYA AHMAD ZAINUDDIN ALFANNANI BAB (SHALAT, ZAKAT, PUASA, HAJI DAN UMRAH, JUAL BELI, DAN IJARAH) (KAJIAN ILMU BADĪ)
Authors: Qodariyah Putri Fatimah , Halim Muhamad Abdul , Nurlinah Nurlinah 
Published: November 2019

This research departs from the fact that the previous books contained many beauties, both in terms of lafadz and meaning. The Fathul Mu'in Book is one of the books written by Ahmad Zainuddin Alfannani, this book discusses the jurisprudence in this book is quite complete covering the chapter thaharah for jinayat or law. The book Fathul Mu'in is one of the books which is more the beauty of language in it, namely jin. Jinn language is the likeness of two lafadz in pronunciation, but the meaning is different. In this study discuss the analysis contained in the Book of Fathul Mu'in, and based on this background, the research is formulated as follows: 1) What is included in the Book of Fathul Mu'in by Ahmad Zainuddin Alfannani Chapter (Prayer, Zakat, Fasting) , Hajj and Umrah, buying and selling, and ijarah) The work of Ahmad Zainuddin Alfannani, 2) Any form of Jinapa which is included in the Book of Fathul Mu'in by Ahmad Zainuddin Alfannani Chapter (Prayer, Zakat, Fasting, Hajj and Umrah, buying and selling, and ijarah) The work of Ahmad Zainuddin Alfannani. This study uses descriptive analysis method, descriptive analysis method is done by describing the facts then followed by analysis. The descriptive method of analysis is not only eye-breaking, but also provides sufficient understanding and explanation of jinās in the Fathul Mu'in book by understanding Balāghah. After conducting the research, the researcher draws the results of the analysis, that the types and forms of Jinās contained in the Fathul Mu'in Chapter (Prayer, Zakat, Hajj and Umrah, buying and selling, ijarah) by Ahmad Zainuddin Bin Abdul Aziz Alfannani are: types Jinās, numbering 87 kinds of Jinās, which includes 7 types of Jinās, namely Jinās tām mumāsil, Jinās tām mustaufi, Jinās ghair tām naqis mudhōri ', Jinās tām, Jinās ghair tām naqis lāhi), Jinās ghair tām qolab kul, and Jinās ghair tām qolab ba'di kulk, and Form Jinās, totaling 145 forms, which consist of fi'il (verb) and isim (noun) arrangement. The fiil is fi'il Mādi and Fi'il Mudōri. The isim in the book is masdar isim, isim fa'il isim maf'ul and isim jamid.
Access to Novel Drugs for Non-Small Cell Lung Cancer in Central and Southeastern Europe: A Central European Cooperative Oncology Group Analysis
Authors: Cufer Tanja , Ciuleanu Tudor E. , Berzinec Peter , Galffy Gabriela , Jakopovic Marko , Jassem Jacek , Jovanovic Dragana , Mihaylova Zhasmina , Ostoros Gyula , Thallinger Christiane , Zemanova Milada , Zielinski Christoph 
Published: November 2019

Abstract

Background
Treatment of non-small cell lung cancer (NSCLC) improved substantially in the last decades. Novel targeted and immune-oncologic drugs were introduced into routine treatment. Despite accelerated development and subsequent drug registrations by the European Medicinal Agency (EMA), novel drugs for NSCLC are poorly accessible in Central and Eastern European (CEE) countries.

Material and Methods
The Central European Cooperative Oncology Group conducted a survey among experts from 10 CEE countries to provide an overview on the availability of novel drugs for NSCLC and time from registration to reimbursement decision in their countries.

Results
Although first-generation epidermal growth factor receptor tyrosine kinase inhibitors were reimbursed and available in all countries, for other registered therapies—even for ALK inhibitors and checkpoint inhibitors in first-line—there were apparent gaps in availability and/or reimbursement. There was a trend for better availability of drugs with longer time from EMA marketing authorization. Substantial differences in access to novel drugs among CEE countries were observed. In general, the availability of drugs is not in accordance with the Magnitude of Clinical Benefit Scale (MCBS), as defined by the European Society for Medical Oncology (ESMO). Time spans between drug registrations and national decisions on reimbursement vary greatly, from less than 3 months in one country to more than 1 year in the majority of countries.

Conclusion
The access to novel drugs for NSCLC in CEE countries is suboptimal. To enable access to the most effective compounds within the shortest possible time, reimbursement decisions should be faster and ESMO MCBS should be incorporated into decision making.
Blood-Based Next-Generation Sequencing Analysis of Appendiceal Cancers
Authors: Shaib Walid L. , Zakka Katerina , Staley Charles , Roberts Ali , Akce Mehmet , Wu Christina , Alese Olatunji B. , El-Rayes Bassel F. 
Published: November 2019

AbstractBackgroundAppendiceal cancers (ACs) are rare. The genomic landscape of ACs has not been well studied. The aim of this study was to confirm the feasibility of next-generation sequencing (NGS) using circulating tumor DNA (ctDNA) in ACs and characterize common genomic alterations.Materials and MethodsMolecular alterations in 372 plasma samples from 303 patients with AC using clinical-grade NGS of ctDNA (Guardant360) across multiple institutions were evaluated. Test detects single nucleotide variants in 54–73 genes, copy number amplifications, fusions, and indels in selected genes.ResultsA total of 303 patients with AC were evaluated, of which 169 (56%) were female. Median age was 56.8 (25–83) years. ctDNA NGS testing was performed on 372 plasma samples; 48 patients had testing performed twice, 9 patients had testing performed three times, and 1 patient had testing performed four times. Genomic alterations were defined in 207 (n = 207/372, 55.6%) samples, and 288 alterations were identified excluding variants of uncertain significance and synonymous mutations. Alterations were identified in at least one sample from 184 patients; TP53-associated genes (n = 71, 38.6%), KRAS (n = 33, 17.9%), APC (n = 14, 7.6%), EGFR (n = 12, 6.5%), BRAF (n = 11, 5.9%), NF1 (n = 10, 5.4%), MYC (n = 9, 4.9%), GNAS (n = 8, 4.3%), MET (n = 6, 3.3%), PIK3CA (n = 5, 2.7%), and ATM (n = 5, 2.7%). Other low-frequency but clinically relevant genomic alterations were as follows: AR (n = 4, 2.2%), TERT (n = 4, 2.2%), ERBB2 (n = 4, 2.2%), SMAD4 (n = 3, 1.6%), CDK4 (n = 2, 1.1%), NRAS (n = 2, 1.1%), FGFR1 (n = 2, 1.1%), FGFR2 (n = 2, 1.1%), PTEN (n = 2, 1.1%), RB1 (n = 2, 1.1%), and CDK6, CDKN2A, BRCA1, BRCA2, JAK2, IDH2, MAPK, NTRK1, CDH1, ARID1A, and PDGFRA (n = 1, 0.5%).ConclusionEvaluation of ctDNA is feasible among patients with AC. The frequency of genomic alterations is similar to that previously reported in tissue NGS. Liquid biopsies are not invasive and can provide personalized options for targeted therapies in patients with AC.Implications for PracticeThe complexity of appendiceal cancer and its unique genomic characteristics suggest that customized combination therapy may be required for many patients. Theoretically, as more oncogenic pathways are discovered and more targeted therapies are approved, customized treatment based on the patient's unique molecular profile will lead to personalized care and improve patient outcomes. Liquid biopsies are noninvasive, cost-effective, and promising methods that provide patients with access to personalized treatment.
Crustal Structure of Eastern North Carolina: Piedmont and Coastal Plain
Authors: Zhao Shuai , Guo Wenbin 
Published: November 2019

Abstract
We present the results from an onshore seismic refraction and wide‐angle reflection profile, conducted in 2015, across the coastal plain and eastern Piedmont provinces of North Carolina. We use forward modeling to create 1D synthetic seismogram models and then invert first break picks to create 2D P‐ and S‐wave velocity models. The crustal thickness is 38 km beneath the Piedmont and central coastal plain, but it thins to 32 km at the coastline. The average thickness of the upper crust is 11 km with an average P‐wave velocity (VP) of 6.0  km/s and S‐wave velocity (VS) of 3.5  km/s. A prominent seismic low‐velocity zone (LVZ) (VP<6.0 and VS<3.6  km/s) exists between the depths of 6 and 11 km, beneath the western third of the seismic profile. The middle crust varies greatly in thickness, increasing from 3 km in the west (eastern Piedmont) to 13 km in the east (coastal plain), with seismic velocities of 6.5  km/s for VP and 3.8  km/s for VS. The lower crust thins significantly toward the rifted Atlantic margin, decreasing from 24 km thick in the west (Piedmont) to 8 km at the coastline, with velocities of approximately 6.9  km/s for VP and 3.9  km/s for VS. We estimate the composition of the crust by comparing the measured values of VP and Poisson’s ratio with laboratory measurements. The upper and middle crusts are in agreement with a felsic composition, while the lower crustal composition is predominately felsic to intermediate. The LVZ in the upper crust is associated with thin layers of the mylonitic rocks involved in the top and the bottom of thrusting, and the top of the lower crust could be the master detachment fault during the thin‐skinned Alleghanian orogeny. The eastward thinning of the lower crust is consistent with crustal extension during the Mesozoic rifting of the Atlantic margin.