bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference between the biologic and chronologic age as an individualized indicator for the skin care intensity selection: skin topography and immune system state studies, parameter correlations with age difference
Authors: Sukhovei Yurij , Kostolomova Elena , Unger Irina , Koptyug Andrey , Kaigorodov Denis 
Published: December 2019

Abstract
Background
Present research addresses the issue of skin aging and corresponding skin treatment individualization. Particular research question was on the developing of simplified criterion supporting patient-specific decision on the necessity and intensity of skin treatment. Basing on the published results and a wide pool of experimental data, we have formulated a hypothesis that a difference between biologic and chronologic age can be used as an express criterion of skin aging.

Methods
In present paper, we report the results of studies with 80 volunteers between 15 and 65 years of age, linking parameters reflecting immune state, skin state, and topography to the difference between biologic and chronologic age. Facial skin topography, skin moisture, sebum level, and skin elasticity were studied using commercial devices. Blood immunology studies were performed using venous blood samples. Correlations between all measured parameters and age difference were calculated. Also, cross correlations between skin cell profile and blood immune profile parameters, and skin roughness parameters were calculated.

Results
Age dependencies of the blood immunological parameters on the biologic and chronologic age difference are less pronounced as compared to the changes in skin cell profile parameters. However, the changes in the tendencies when biologic age becomes equal to chronologic one are visible for all studied parameters.
All measured skin roughness parameters show correlations with age difference, but average skin roughness and depth of the deepest profile valley have the largest correlation coefficient values. Many of the measured skin cell profile and blood immunology parameters show strong correlations with average skin roughness and deepest profile valley, with some of the coefficients exceeding 0.5–0.6.

Conclusions
Basing on own experiments and published research results, it is possible to suggest using the difference between calculated biologic age and chronologic age as an individualized criterion supporting decisions on skin treatment strategy. Further research involving larger numbers of participants and aiming on optimizing the expressions for calculating biologic age could lead to reliable and easily available express criterion supporting the decision making for an individualized skin treatment.
Blood biomarkers for stroke: the role of thioredoxin in diagnosis and prognosis of acute ischemic stroke
Authors: Oraby Mohammed I. , Rabie Radwa A. 
Published: December 2019

Abstract
Background
Oxidative stress plays a crucial role in the pathophysiology of acute ischemic stroke. Thioredoxin exists and released from cells during inflammation and oxidative stress and was recognized as an oxidative-stress marker.

Objective
The objective of this study was to assess the role of thioredoxin as an oxidative stress biomarker in diagnosis and prognosis of acute ischemic stroke in a sample of patients recruited from Beni-Suef Governorate, north Upper Egypt.

Methods
A case control study included 100 subjects; 50 patients with first-ever acute ischemic stroke presented within 24 h from the onset and 50 healthy volunteers as a control. Clinical, functional, and radiological evaluation was done for the patients, and all patients and control were subjected to routine laboratory tests and assessment of serum level of thioredoxin by solid-phase sandwich enzyme-linked immunosorbent assay.

Results
Thioredoxin was significantly higher in acute stroke patients compared to control group (p value = 0.001). Thioredoxin level was significantly higher in hypertensive patients (p value = 0.007), patients who had carotid stenosis ≥50% (p value = 0.001), patients with poor outcome (p value = 0.009), and in patients with cardio-embolic stroke (p value = 0.001).
Significant positive correlation was found between thioredoxin level and volume of infarction (r = 0.501 and p = 0.001), stroke severity at presentation (r = 0.503 and p = 0.021) and clinical outcome after 3 months (r = 0.551 and p value = 0.001).

Conclusion
Thioredoxin as a marker of oxidative stress can be used as a new diagnostic and prognostic blood biomarker for stroke.
A hospital-based study of post-stroke aphasia: frequency, risk factors, and topographic representation
Authors: Khedr Eman M. , Abbass Mohamed A. , Soliman Radwa K. , Zaki Ahmed F. , Gamea Aymen , El-Fetoh Noha Abo , Abdel-Aaal Mahmoud A. 
Published: December 2019

AbstractBackground and objectiveThe crude prevalence rate of stroke in Qena, Egypt, is high (922/100,000). For the first time, we estimate the frequency of aphasia following the first-ever ischemic stroke and its relationship to the site of lesion in Arabic-speaking countries.MethodsThe study was conducted on 180 acute or subacute ischemic stroke patients. Aphasia was diagnosed with the short form of the Boston Diagnostic Aphasia Examination after establishment of the cases (at least 10 days of stroke onset). Computed tomography and/or magnetic resonance imaging were performed for topographic localization of stroke, and routine laboratory investigations were done to evaluate the possible stroke risk factors.ResultsThe frequency of post-stroke aphasia was recorded in 20%, and atrial fibrillation (AF) represents a high-risk factor for ischemic stroke with aphasia. The following categories were observed: global aphasia in 50%, motor aphasia in 27.7%, sensory aphasia in 11.1%, nominal aphasia in 2.8%, and conductive aphasia in 8.3%. Global aphasia was mainly associated with complete middle cerebral artery (MCA) territories infarction. Motor aphasia was associated mainly with frontal or frontoparietal operculum lesions as well as basal ganglionic lesions. Sensory aphasia was associated with temporal lobe lesions, inferior parietal lobe, and basal ganglia. Conductive aphasia showed lesions in the deep white matter of the frontal and parietal lobes. Anomic aphasia was associated with inferior parietal lobe lesion.ConclusionOur data are consistent with other reports as regards the frequency and risk factors of post-stroke aphasia. Atrial fibrillation represents a high-risk factor for ischemic strokes with aphasia. Global and motor aphasia are the major subtypes. The lesion locations are predictive of aphasia subtypes.
Physiological and biochemical responses of soybean (Glycine max L.) to cysteine application under sea salt stress
Authors: Sadak Mervat Sh. , Abd El-Hameid Asmaa R. , Zaki Faten S. A. , Dawood Mona G. , El-Awadi Mohamed E. 
Published: December 2019

Abstract
Background
Shortage of water is a major problem facing Egypt; thus, it becomes necessary to use non-traditional sources of water such as saline water in irrigation. Overcoming the adverse effects of saline water and enhancing plant tolerance to salinity stress is the main challenge for increasing plant growth and productivity. Using a natural compound such as cysteine amino acid has an important effect in alleviating the adverse effect of salinity stress on different plant crops.

Materials and methods
Two pot experiments were carried out during two successive summer seasons to study the beneficial role of cysteine (0, 20, and 40 mg/l) in enhancing growth, some metabolic process, and seed yield quality and quantity of soybean plant grown under salinity stress (0, 3000, and 6000 mg/l).

Results
Salinity stress (3000 and 6000 mg/l) caused decreases in soybean growth criteria (plant height, number of branches and leaves/plant, dry weight of leaves and stem/plant), photosynthetic pigments and some element contents (nitrogen (N), phosphorus (P), and potassium (K)), and seed yield and yield components (number of pods/plant, weight of pods/plant and number of seeds/plant) as well as oil%. Meanwhile, proline, H2O2 and MDA contents, and superoxide dismutase activity were gradually increased by increasing salinity level. On the other hand, cysteine treatments improved growth and yield of soybean plant either irrigated with tap water or saline water. Cysteine treatments could alleviate the adverse effect of salinity stress on growth and yield of soybean plant through increasing photosynthetic pigments; proline content; N, P, and K contents; superoxide dismutase and catalase activities; and oil% accompanied by decreases in H2O2 and MDA contents as compared with their corresponding controls. In addition, cysteine treatments and/or salinity stress exhibited differences in protein pattern from 112 to 19 kD molecular weight. The appearance of new protein bands reflected the expression of cysteine treatments and salinity stress.

Conclusion
Cysteine treatments had a beneficial role in alleviating the adverse effect of salinity stress on soybean plant. Forty milligrams per liter of cysteine was the most effective treatment in enhancing salinity tolerance of soybean plant.
Antibacterial effect of metallic nanoparticles on Streptococcus mutans bacterial strain with or without diode laser (970 nm)
Authors: Sadony Doaa M. , Abozaid Hanan El-sayed 
Published: December 2019

Abstract
Background
The main etiological agent for dental caries is Streptococcus mutans bacterial strain. Recently, metallic nanoparticles and diode laser have been introduced as a new method in bacterial decontamination. Nanoparticles have very small particles size that has greater surface area and exert their antimicrobial effect by interacting with the negatively charged bacterial cell wall, while lasers have become increasingly popular in dentistry due to their multiple uses, and one such important application is tooth disinfection.

Objective
Present study was conducted to evaluate antimicrobial efficacy of silver (AgNPs) and gold nanoparticles (AuNPs) with and without diode laser (970 nm, 15 Hz, 100 mJ, 2 W, each cycle was 10 s and repeated 6 times with intervals of 5 s for each sample) irradiation against experimentally inoculated S. mutans bacteria in the samples.

Material and methods
Thirty freshly a traumatically extracted premolars human tooth were collected, and cylindrical cavity in crowns with 4 mm diameter and 5 mm depth was prepared and inoculated with S. mutans for 24 h. The tooth were randomlly divided into equal expermintal groups (6 each): group 1, positive control group by S. mutans bacterial strain; group 2, irrigation with silver nanoparticles (AgNPs) for 3 min; group 3, irrigation with gold nanoparticles (AuNPs) for 3 min; group 4, 3 ml AgNPs + irradiation with diode laser for 60 s; and group 5, 3 ml AuNPs + irradiation with diode for 60 s. The specimens were collected from the teeth sample, and colony-forming units (CFU’s) were observed by counting the bacteria colony on plates.

Results
A significant difference was found among all the groups in comparison to the control group (p < 0.05). The greatest reduction in CFU’s was observed in combination of AgNPs with diode laser group.

Conclusions
The NPs in combination with diode laser irradiation has the potential to be used as dentine disinfectant.
The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis
Authors: dos Santos Alexandre Moura , Missé Rafael Giovani , Borges Isabela Bruna Pires , Shinjo Samuel Katsuyuki 
Published: December 2019

Abstract
Background
This study was aimed at evaluating the aerobic capacity of patients with antisynthetase syndrome (ASS) and dermatomyositis (DM) and analyzing possible relationships between aerobic capacity and disease status, cardiovascular diseases and their risk factors.

Methods
The study was a cross-sectional, single-center study that assessed the aerobic capacity of 22 women (13 with DM and 9 with ASS) who were matched by age and body mass index to 17 healthy women (control group). The aerobic capacity (oxygen uptake [VO2 peak], anaerobic threshold, respiratory compensation point and time-to-exhaustion) was evaluated using the cardiopulmonary treadmill test. Disease status was assessed using International Myositis Assessment & Clinical Studies Group (IMACS) set scores.

Results
The patients had low IMACS parameters that showed low or absent disease activity. The distribution of cardiovascular diseases and their risk factors was similar between the patients and the control group (P >  0.05) at the time of the analysis. The patients with DM and the control group had similar aerobic capacity. However, the patients with ASS exhibited significantly reduced aerobic capacity (relative VO2 peak, anaerobic threshold, respiratory compensation point and time to exhaustion) when compared to the control group. In addition, patients with ASS had a lower anaerobic threshold compared to the DM group. There were no significant relationships between the aerobic capacity and disease status, cardiovascular diseases and their risk factors.

Conclusion
In contrast to DM patients and healthy individuals, patients with stable ASS have significantly impaired aerobic capacity, which is unlikely to be totally explained by traditional cardiovascular diseases, their risk factors and disease status. Further studies are needed to corroborate our data and to clarify the cause of this reduced aerobic capacity in ASS.
Outcomes and component-positioning in total knee arthroplasty may be comparable between supervised trained surgeons and their supervisor
Authors: Goto Kazumi , Katsuragawa Yozo , Miyamoto Yoshinari 
Published: December 2019

Abstract
Purpose
There are concerns that malalignment in total knee arthroplasty (TKA) occurs with less experienced surgeons. This study investigates the influence of surgical experience on TKA outcomes.

Materials and methods
Nineteen patients (38 knees) who underwent bilateral TKA between 2011 and 2015 were included. A supervisor performed knee replacements associated with lower Knee Society Scores (KSS); trainee surgeons operated on the other knee. Knees were categorized into two groups: operations by the supervisor (group S) versus operations by trainee surgeons (group T). Range of motion (ROM), KSS, operative time, hip–knee–ankle angle, and femoral and tibial component angle were evaluated.

Results
The mean operative time was 92.5 min in group S and 124.2 min in group T (p < 0.01). The mean postoperative maximal flexion was 113.2° in group S and 114.2° in group T (not significant). The mean postoperative KSS was 92.9 in group S and 93.9 in group T (not significant). No significant differences between groups in terms of proportion of inliers for the hip–knee–ankle angle, femoral component angle, or tibial component angle were observed.

Conclusions
Although operative time was significantly longer for trainee surgeons versus the supervisor, no significant differences in ROM, KSS, or component positioning between supervisor and trainee surgeons were observed.

Level of evidence
IV (retrospective case series design).
Correlation between meniscal extrusion and symptom duration, alignment, and arthritic changes in medial meniscus posterior root tear: research article
Authors: Kim Dong Hwi , Lee Gwang Chul , Kim Hyun Hak , Cha Dong Hyuk 
Published: December 2019

Abstract
Background
Medial meniscus posterior root tear can result in medial meniscus extrusion. However, the severity of medial meniscus extrusion is different in each root tear patient. The purpose of this study was to identify the factors that contribute to the severity of medial meniscus extrusion with medial meniscus posterior root tear, such as duration of disease, the degree of arthritis—chondral wear, subchondral edema, osteophyte size, and Kellgren–Lawrence (K/L) grade—and mechanical alignment for appropriate treatment method.

Methods
From January 2009 to August 2014, we retrospectively analyzed magnetic resonance imaging (MRI) and simple x-ray of 99 patients with medial meniscus posterior root tear. The duration of the disease was identified through retrospective chart review. The severity of medial meniscus extrusion, the presence of subchondral edema, the degree of chondral wear, and the size of the osteophyte were measured on MRI. K/L grade was confirmed on simple x-ray, and the mechanical axis was measured on whole extremity radiographs. Statistical analysis was performed by using bivariate correlation analysis and one-way analysis of variance.

Results
The mean medial meniscus extrusion was 4.61 mm, and the mean duration of the disease was 15.52 months. The mean degree of chondral wear was 25.8%, and 63 out of 99 cases showed subchondral edema. The average alignment was 4.30 degrees, and the average size of the osteophyte was 1.48 mm. There were 40 cases (40.4%) with K/L grade I, 48 cases (48.5%) with grade II, 11 cases (11.1%) with grade III, and no cases with grade IV. In the group mean analysis between the K/L grade and the severity of medial meniscus extrusion, the average medial meniscus extrusions were 3.97 mm in grade I, 4.93 mm in grade II, and 5.59 mm in grade III. There was a statistical significance between the size of the osteophyte and the severity of medial meniscus extrusion (P = 0.000), K/L grade, and the severity of medial meniscus extrusion (P = 0.001).

Conclusions
The severity of medial meniscus extrusion with medial meniscus posterior horn root tear is associated with the size of the osteophyte and K/L grade.
Short knee radiographs can be inadequate for estimating TKA alignment in knees with bowing
Authors: Oh Sung-Mok , Bin Seong-Il , Kim Jae-Young , Lee Bum-Sik , Kim Jong-Min 
Published: December 2019

Abstract
Purpose
The aim of this study was to compare the discrepancy of alignment categorization in total knee arthroplasty (TKA) between the anatomical femorotibial angle (aFTA) measured on short knee radiographs and the mechanical hip–knee–ankle axis angle (mHKA) measured on full-length radiographs in knees with and without bowing.

Methods
From January 2014 to June 2017, 107 of 526 osteoarthritic knees at our hospital were found to have femoral or tibial bowing. Bowing was defined as a femoral bowing angle (FBA) > 3° or < − 3° or a tibial bowing angle (TBA) > 2° or < − 2° in full-length preoperative radiographs. Among 419 knees without bowing, we selected 107 knees as a control group using propensity-score matching. Postoperative alignments were categorized by aFTA in short knee radiographs and mHKA in full-length radiographs into neutral (2° ≤ aFTA≤7°, − 3° ≤ mHKA≤3°), varus (aFTA< 2°, mHKA<− 3°), and valgus (aFTA> 7°, mHKA> 3°) alignments. We compared the categorization of alignments between knees with and without bowing using the McNemar test and used logistic regression to find factors for the alignment discordance.

Results
Coronal alignment was discordant in 26.2% of the knees with bowing and 13.1% of the knees without bowing (p < 0.001). FBAs were a significant factor affecting the discordance of alignment categorization (OR = 1.152, 95%CI 1.038–1.279, p = 0.008).

Conclusion
Short knee radiographs are insufficient for estimating coronal alignment after TKA, particularly in knees with femoral bowing.

Level of evidence: III
Retrospective comparative study.
Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis
Authors: Daryanto Besut , Purnomo Basuki Bambang , Gunawan Atma , Tamara Fredo , Hutama Saga Aditya , Mayasari Ema Dianita , Kusumaningrum Arum Gladys , Fajar Jonny Karunia 
Published: December 2019

Abstract
Backgrounds
In the last two decades, studies have been widely carried out to assess the association between single-nucleotide polymorphisms (SNPs) of calcium-sensing receptor (CaSR) gene in exon 7 and the risk of urolithiasis. However, inconsistency across the studies was reported. Therefore, our current study aimed to perform a meta-analysis concerning the association between the risk of urolithiasis and the gene polymorphisms of CaSR R990G, CaSR A986S, and CaSR Q1011E.

Methods
Published papers from PubMed, Embase, Cohcrane, and Web of science were included for the study, and they were analyzed using fixed or random effect model.

Results
A total of 11 papers consisting of eight papers evaluating CaSR R990G, nine papers evaluating CaSR A986S, and five papers evaluating CaSR Q1011E were included in our analysis. Our pooled calculation found that protective effect against urolithiasis was observed in R allele and RR genotype of CaSR R990G and A allele and AA genotype of CaSR A986S. Conversely, increased susceptibility to urolithiasis was found in G allele and RG genotype of CaSR R990G and S allele of CaSR A986S. Interestingly, our findings in sub-group analysis confirmed that the correlation between CaSR R990G and urolithiasis was found in Caucasian population. Meanwhile, in Asian population, the association was observed in CaSR A986S.

Conclusions
CaSR R990G and CaSR A986S, but not CaSR Q1011E, are associated with the risk of urolithiasis.
Groin Injuries in Soccer: Investigating the Effect of Age on Adductor Muscle Forces
Authors: DUPRÉ THOMAS , LYSDAL FILIP GERTZ , FUNKEN JOHANNES , MORTENSEN KRISTIAN R. L. , MÜLLER RALF , MAYER JAN , KRAHL HARTMUT , POTTHAST WOLFGANG 
Published: December 2019

ABSTRACT

Purpose
The sudden rise in the injury incidence during adolescence is also evident in soccer-related injuries to the groin. Submaximal passing applies high stress on the adductor muscles and pubic symphysis and is therefore likely to be connected to the occurrence of groin injuries. Therefore, the purpose of the study was to compare hip joint kinematics and adductor muscle forces of different adolescent age groups during submaximal soccer passing.

Methods
Sixty participants, in four groups, younger than 12, 15, 16. and 23 yr (U12, U15, U16, U23), were analyzed. A Footbonaut, equipped with a 3D motion capture system consisting of 16 cameras, was used to capture kinematic data of short passes. Inverse dynamic analysis was performed to calculate muscle forces of 10 passes of each subject.

Results
The U15 group showed reduced angular velocities. A rise in hip adductor muscle forces was evident from the youngest group up to the oldest groups. The largest increase (49%) was found between U12 and U15. Lower-limb mass was identified as the best predictor for the increasing adductor force.

Conclusions
The reduced angular velocities of the U15 and the increase in muscle forces between all age groups were attributed to the increasing segment masses and length. This increases the moments of inertia of the leg segments thereby demanding higher forces to accelerate the segments. Most likely, the stress put upon the adductors apophyses increases during adolescence, as tendons are known to adapt slower than muscles, increasing the risk for overuse injuries. Coaches could use lower-limb mass as an indicator for fast increases in the force demand to identify players who would benefit from a reduced training volume.