bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and internal validation of a prognostic model for mortality of patients with abdominal aortic aneurysms treated with endovascular aneurysm repair
Authors: Meuli Lorenz , Yu Ly-Mee , Wyss Thomas R. , Schmidli Juerg , Makaloski Vladimir 
Published: October 2020

Summary: Background: Morbidity and mortality associated with elective endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) must be balanced against the impending risk of aneurysm rupture and the estimated remaining lifetime. The aim of this study is to develop and validate a prognostic model for mortality of patients with AAA treated with EVAR. Methods: This retrospective observational study included 251 consecutive patients treated with EVAR for asymptomatic AAA between January 2001 and December 2012 at the University Hospital in Bern, Switzerland. Pre-selection of variables was based on a literature review; least absolute shrinkage and selection operator technique was used for the final variable selection. A Firth’s bias reduced Cox proportional hazard model was developed and validated using 10,000 bootstrap samples to predict survival after EVAR. Results: The median follow-up time was 5.3 years (range 0.1 to 15.9). At the study closing date 95% of follow-up information was available. The mortality rates were 31.9% at 5 years and 50.5% at the study closing date, respectively. Identified predictors for overall mortality after EVAR were age, hazard ratio (HR) = 2.24 per 10-year increase (95% CI 1.64 to 3.09), the presence of chronic obstructive pulmonary disease (COPD), HR = 2.22 (95% CI 1.48 to 3.31), and lower estimated glomerular filtration rate, HR = 1.24 per 10 ml/min/1.73 m2decrease (95% CI 1.12 to 1.39). The model showed good discrimination ability, Harrell’s C = 0.722 (95% CI 0.667 to 0.778) and was very robust in the bootstrap in-sample validation Harrell’s C = 0.726 (95% CI 0.662 to 0.788). Conclusion: Higher age, the presence of COPD and impaired kidney function are independent predictors for impaired survival after EVAR. The expected remaining lifetime should be considered in patients with AAA. This prognostic model can help improving patient care; however, external validation is needed prior to clinical implementation.
Interpreting Inverse Magnetic Fabric in Miocene Dikes From Eastern Iceland
Authors: Trippanera D. , Porreca M. , Urbani S. , Kissel C. , Winkler A. , Sagnotti L. , Nazzareni S. , Acocella V. 
Published: October 2020

AbstractAnisotropy of Magnetic Susceptibility (AMS) is a valid tool to investigate magma flow direction within dikes. However, geometrically inverse magnetic fabric characterized by maximum magnetic susceptibility axis (kmax) perpendicular to the dike wall may complicate the interpretation of flow trajectories. To better understand the nature of this fabric, we present a multiscale study on 19 dikes (383 samples) in the Miocene Alftafjordur volcanic system (Iceland), where 80% of the samples show a geometrically inverse magnetic fabric. We carried out (1) AMS measurements at different magnetic fields and temperatures, along with Anisotropy of Anhysteretic Remanent Magnetization (AARM) analysis; (2) hysteresis loops and FORC diagrams; (3) thin section analysis; (4) structural fieldwork. A variable Ti‐content (0.1 < x < 0.6, Fe3‐xTixO4) titanomagnetite is the main magnetic carrier, and the contribution of the paramagnetic elongated crystals to the magnetic fabric is negligible. Single domain is not the prevailing domain state of the magnetic particles, suggesting that its occurrence cannot be the main cause for the inverse fabric. AMS analysis at different fields and temperatures along with AARM allow us to exclude any mineral phase change of the titanomagnetite across the dike. Nevertheless, kmax is parallel to a diffuse horizontal column‐like fracture pattern perpendicularly oriented with respect to the dike strike. This suggests that the Ti‐magnetite mineral orientation during dike cooling was affected by the fracture network progressively developing columnar basalts. This study demonstrates that the interpretation of AMS data on old and deep volcanic bodies is not straightforward and observations at different scales are required.
Studies of the 2018/Mars Year 34 Planet‐Encircling Dust Storm
Authors: Guzewich S. D. , Fedorova A. A. , Kahre M. A. , Toigo A. D. 
Published: October 2020

AbstractMars’ planet‐encircling or global dust storms (GDSs) are an iconic and enigmatic feature of the Red Planet. Occurring every few Mars Years (MYs), on average, they are a stochastic process in the otherwise largely repeatable annual cycle of martian weather. In 2018 (MY 34 in the calendar of Clancy et al. [2000], https://doi.org/10.1029/1999je001089), an international fleet of spacecraft–six orbiters and two rovers–observed the most recent GDS. This introduction and the articles of this special collection describe the evolution and impacts of the storm from the surface to the exosphere, compare this storm to previous GDSs, identify new phenomena never previously seen in such storms, and attempt to determine how and when GDSs develop.
Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3
Authors: Yoshida Akihiro , Choi Jaewoo , Jin Hong Ri , Li Yan , Bajpai Sagar , Qie Shuo , Diehl J. Alan 
Published: October 2020

AbstractOverexpression of D-type cyclins in human cancer frequently occurs as a result of protein stabilization, emphasizing the importance of identification of the machinery that regulates their ubiqutin-dependent degradation. Cyclin D3 is overexpressed in ~50% of Burkitt’s lymphoma correlating with a mutation of Thr-283. However, the E3 ligase that regulates phosphorylated cyclin D3 and whether a stabilized, phosphorylation deficient mutant of cyclin D3, has oncogenic activity are undefined. We describe the identification of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3. SCF-Fbxl8 poly-ubiquitylates p-Thr-283 cyclin D3 targeting it to the proteasome. Functional investigation demonstrates that Fbxl8 antagonizes cell cycle progression, hematopoietic cell proliferation, and oncogene-induced transformation through degradation of cyclin D3, which is abolished by expression of cyclin D3T283A, a non-phosphorylatable mutant. Clinically, the expression of cyclin D3 is inversely correlated with the expression of Fbxl8 in lymphomas from human patients implicating Fbxl8 functions as a tumor suppressor.
Active learning of deep surrogates for PDEs: application to metasurface design
Authors: Pestourie Raphaël , Mroueh Youssef , Nguyen Thanh V. , Das Payel , Johnson Steven G. 
Published: October 2020

AbstractSurrogate models for partial differential equations are widely used in the design of metamaterials to rapidly evaluate the behavior of composable components. However, the training cost of accurate surrogates by machine learning can rapidly increase with the number of variables. For photonic-device models, we find that this training becomes especially challenging as design regions grow larger than the optical wavelength. We present an active-learning algorithm that reduces the number of simulations required by more than an order of magnitude for an NN surrogate model of optical-surface components compared to uniform random samples. Results show that the surrogate evaluation is over two orders of magnitude faster than a direct solve, and we demonstrate how this can be exploited to accelerate large-scale engineering optimization.
The Kasei Valles, Mars: a unified record of episodic channel flows and ancient ocean levels
Authors: Duran Sergio , Coulthard Tom J. 
Published: October 2020

AbstractThere is widespread evidence across Mars of past flows in major channel systems as well as more than one palaeo ocean level. However, evidence for the timing of channel flows and ocean levels is based on geographically diverse sources with a limited number of dates, making reconstructions of palaeo flows and ocean levels patchy. Here, based on high-resolution topography, image analysis and crater statistics, we have dated 35 different surfaces in Kasei Valles, that are predominantly found within erosional units enabling us to reconstruct a fascinating timeline of episodic flooding events (ranging from 3.7 to 3.6 Ga to ca. 2.0 Ga) interacting with changing ocean/base levels. The temporal correlation of the different surfaces indicates five periods of channel flows driving the evolution of Kasei Valles, in conjunction with the development of (at least) two ocean levels. Furthermore, our results imply that such ocean rose in elevation (ca. 1000 m) between ca. 3.6 Ga and 3.2 Ga and soon afterwards disappeared, thereby indicating a complex ancient Martian hydrosphere capable of supporting a vast ocean, with an active hydrological cycle stretching into the Amazonian.
Empirical dynamics of railway delay propagation identified during the large-scale Rastatt disruption
Authors: Büchel Beda , Spanninger Thomas , Corman Francesco 
Published: October 2020

AbstractTransport networks are becoming increasingly large and interconnected. This interconnectivity is a key enabler of accessibility; on the other hand, it results in vulnerability, i.e. reduced performance, in case any specific part is subject to disruptions. We analyse how railway systems are vulnerable to delay, and how delays propagate in railway networks, studying real-life delay propagation phenomena on empirical data, determining real-life impact and delay propagation for the uncommon case of railway disruptions. We take a unique approach by looking at the same system, in two different operating conditions, to disentangle processes and dynamics that are normally present and co-occurring in railway operations. We exploit the unique chance to observe a systematic change in railway operations conditions, without a correspondent system change of infrastructure or timetable, coming from the occurrence of the large-scale disruption at Rastatt, Germany, in 2017. We define new statistical methods able to detect weak signals in the noisy dataset of recorded punctuality for passenger traffic in Switzerland, in the disrupted and undisrupted state, along a period of 1 year. We determine how delay propagation changed, and quantify the heterogeneous, large-scale cascading effects of the Rastatt disruption towards the Swiss network, hundreds of kilometers away. Operational measures of transport performance (i.e. punctuality and delays), while globally being very decreased, had a statistically relevant positive increase (though very geographically heterogeneous) on the Swiss passenger traffic during the disruption period. We identify two factors for this: (1) the reduced delay propagation at an international scale; and (2) to a minor extent, rerouted railway freight traffic; which show to combine linearly in the observed outcomes.
A unique mineralization mode of hypermineralized pleromin in the tooth plate of Chimaera phantasma contributes to its microhardness
Authors: Iijima Mayumi , Ishiyama Mikio 
Published: October 2020

AbstractTooth plates of the chimaeroids, holocephalian fishes, are unique dental hard tissues. Unlike the teeth of other animals, the tooth plates are located on the roof of the mouth and in the lower jaw. Their tooth plates consist, to a large extent, of lightly mineralized tissue (osteodentin) and hypermineralized tissue (pleromin). Notably, the mineral phase of pleromin is whitlockite, while that of other animals is apatite. Dietary habits of chimaeroids and wearing features of their tooth plates suggest an extreme hardness of pleromin, but this has never been investigated. We examined the microhardness of the tooth plate of Chimaera phantasma and found that pleromin in the biting region was extremely hard, comparable with the hardness of mature tooth enamel, whereas the hardness of immature pleromin was lower than that of bovine dentin. The hardness of osteodentin, on the other hand, was equivalent to that of bovine dentin and almost the same throughout the tooth plate. Immature pleromin was sparsely packed with oval crystals of whitlockite and, as pleromin matures, the space between crystals was filled with small intercrystalline materials. The maturing process of pleromin could partly contribute to its remarkable hardness and have some implications for designing novel biomaterials.
Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma
Authors: Liu Zhi-Qin , Lu Mei-Yin , Liu Bin 
Published: October 2020

AbstractThe current biomarkers for postoperative fertility assessment caused by ovarian endometrioma (OE) are insufficient. The present study hypothesized that the peripheral lymphocyte subpopulation can be used as a candidate biomarker of postoperative infertility in OE. The association of the number of circulating CD4/CD8 T, NK, and γδ T cells with postoperative fertility was assessed in 33 OE patients aged 20 ~ 40 years between June 2018 and January 2019. Concomitantly, 68 healthy female subjects were recruited. The changes in the baseline immune characteristics between the two groups were compared. The data demonstrated significant differences in the ratio of CD4/CD8 T cells and the number of CD56+ NKG2D+ NK cells and γδ T cells between OE patients and control subjects. The patients were followed-up till December 2019 and the number of CD56+ NKG2D+ NK cells in the cases was a significant predictor for postoperative fertility as determined by different COX regression models (crude HR = 0.220, 95% CI = 0.059–0.822; adjusted HR = 0.127, 95% CI = 0.024–0.675). A significant delay to successful pregnancy was noted in OE patients (median time, 173 vs. 99 days, log-rank P = 0.013). The present findings suggested that CD56+ NKG2D+ NK cells are a candidate biomarker of postoperative fertility in OE patients. Larger population studies are warranted.
ERgene: Python library for screening endogenous reference genes
Authors: Zeng Zehua , Xiong Yuzhe , Guo Wenhuan , Du Hongwu 
Published: October 2020

AbstractIn gene expression analysis, sample differences and experimental operation differences are common, but sometimes, these differences will cause serious errors to the results or even make the results meaningless. Finding suitable internal reference genes efficiently to eliminate errors is a challenge. Aside from the need for high efficiency, there is no package for screening endogenous genes available in Python. Here, we introduce ERgene, a Python library for screening endogenous reference genes. It has extremely high computational efficiency and simple operation steps. The principle is based on the inverse process of the internal reference method, and the robust matrix block operation makes the selection of internal reference genes faster than any other method.
Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats
Authors: Nwokocha Chukwuemeka R. , Gordon Alexia , Palacios Javier , Paredes Adrian , Cifuentes Fredi , Francis Sheena , Watson JeAnn , Delgoda Rupika , Nwokocha Magdalene , Alexander-Lindo Ruby , Thompson Rory , Minott-Kates Donna , Yakubu Momoh A. 
Published: October 2020

AbstractMelicoccus bijugatus Jacq (Mb) has been reported to have cardiovascular modulatory effects. In this study, we evaluated the antihypertensive effects and mechanism of action of Mb on NG-Nitro-l-arginine Methyl Ester (l-NAME) and Deoxycorticosterone Acetate (DOCA) rat models. Aqueous extract of Mb fruit (100 mg/kg) was administered for 6 weeks to rats by gavage and blood pressure was recorded. Effects of the extract on vascular reactivity was evaluated using isolated organ baths, and tissues were collected for biochemical and histological analysis. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were significantly (P < 0.05) reduced with extract (100 mg/kg) administration and treatment compared to the hypertensive models. Mb (100 µg/mL) reduced the vascular contractility induced by phenylephrine (PE), and caused a dose-dependent relaxation of PE-induced contraction of aortic vascular rings. The vasorelaxation properties seemed to be endothelium dependent, as well as nitric oxide (NO) and guanylyl cyclase, but not prostaglandin dependent. Histomicrograph of transverse sections of the ventricles from the Mb group did not show abnormalities. The extract significantly (P < 0.05) reduced an l-NAME induced elevation of cardiac output and Creatine Kinase Muscle-Brain (CKMB), but had no significant impact on the activities of arylamine N-acetyltransferase. In conclusion, Mb significantly decreased blood pressure in hypertensive models. The extract possesses the ability to induce endothelium dependent vasodilation, which is dependent on guanylyl cyclase but not prostaglandins.
Comparison of manual and machine learning image processing approaches to determine fungiform papillae on the tongue
Authors: Cattaneo Camilla , Liu Jing , Wang Chenhao , Pagliarini Ella , Sporring Jon , Bredie Wender L. P. 
Published: October 2020

AbstractHuman taste perception is associated with the papillae on the tongue as they contain a large proportion of chemoreceptors for basic tastes and other chemosensation. Especially the density of fungiform papillae (FP) is considered as an index for responsiveness to oral chemosensory stimuli. The standard procedure for FP counting involves visual identification and manual counting of specific parts of the tongue by trained operators. This is a tedious task and automated image analysis methods are desirable. In this paper a machine learning image processing method based on a convolutional neural network is presented. This automated method was compared with three standard manual FP counting procedures using tongue pictures from 132 subjects. Automated FP counts, within the selected areas and the whole tongue, significantly correlated with the manual counting methods (all ρs ≥ 0.76). When comparing the images for gender and PROP status, the density of FP predicted from automated analysis was in good agreement with data from the manual counting methods, especially in the case of gender. Moreover, the present results reinforce the idea that caution should be applied in considering the relationship between FP density and PROP responsiveness since this relationship can be an oversimplification of the complexity of phenomena arising at the central and peripherical levels. Indeed, no significant correlations were found between FP and PROP bitterness ratings using the automated method for selected areas or the whole tongue. Besides providing estimates of the number of FP, the machine learning approach used a tongue coordinate system that normalizes the size and shape of an individual tongue and generated a heat map of the FP position and normalized area they cover. The present study demonstrated that the machine learning approach could provide similar estimates of FP on the tongue as compared to manual counting methods and provide estimates of more difficult-to-measure parameters, such as the papillae's areas and shape.
Feasibility of the deep learning method for estimating the ventilatory threshold with electrocardiography data
Authors: Miura Kotaro , Goto Shinichi , Katsumata Yoshinori , Ikura Hidehiko , Shiraishi Yasuyuki , Sato Kazuki , Fukuda Keiichi 
Published: October 2020

AbstractRegular aerobic physical activity is of utmost importance in maintaining a good health status and preventing cardiovascular diseases (CVDs). Although cardiopulmonary exercise testing (CPX) is an essential examination for noninvasive estimation of ventilatory threshold (VT), defined as the clinically equivalent to aerobic exercise, its evaluation requires an expensive respiratory gas analyzer and expertize. To address these inconveniences, this study investigated the feasibility of a deep learning (DL) algorithm with single-lead electrocardiography (ECG) for estimating the aerobic exercise threshold. Two hundred sixty consecutive patients with CVDs who underwent CPX were analyzed. Single-lead ECG data were stored as time-series voltage data with a sampling rate of 1000 Hz. The data of preprocessed ECG and time point at VT calculated by respiratory gas analyzer were used to train a neural network. The trained model was applied on an independent test cohort, and the DL threshold (DLT; a time of VT estimated through the DL algorithm) was calculated. We compared the correlation between oxygen uptake of the VT (VT–VO2) and the DLT (DLT–VO2). Our DL model showed that the DLT–VO2 was confirmed to be significantly correlated with the VT–VO2 (r = 0.875; P < 0.001), and the mean difference was nonsignificant (−0.05 ml/kg/min, P > 0.05), which displayed strong agreements between the VT and the DLT. The DL algorithm using single-lead ECG data enabled accurate estimation of VT in patients with CVDs. The DL algorithm may be a novel way for estimating aerobic exercise threshold.
Walker-like domain wall breakdown in layered antiferromagnets driven by staggered spin–orbit fields
Authors: Otxoa Rubén M. , Roy P. E. , Rama-Eiroa R. , Godinho J. , Guslienko K. Y. , Wunderlich J. 
Published: October 2020

AbstractWithin linear continuum theory, no magnetic texture can propagate faster than the maximum group velocity of the spin waves. Here, by atomistic spin dynamics simulations and supported by analytical theory, we report that a strongly non-linear transient regime due to the appearance of additional magnetic textures results in the breaking of the Lorentz translational invariance. This dynamical regime is akin to domain wall Walker-breakdown in ferromagnets and involves the nucleation of an antiferromagnetic domain wall pair. While one of the nucleated domain walls is accelerated beyond the magnonic limit, the remaining pair remains static. Under large spin–orbit fields, a cascade of multiple generation and recombination of domain walls are obtained. This result may clarify recent experiments on current pulse induced shattering of large domain structures into small fragmented domains and the subsequent slow recreation of large-scale domains.