bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiologic Analysis of Malar Arch Movement in Reduction Malarplasty Without Bony Resection
Authors: Kim Jae-Hee , Lee Hoon Young , Jeong Jae-Yong , Kim Taek-Kyun 
Published: November 2020

Background:
Reduction malarplasty has been popular among Asians with a wide facial width. In general, malar setback after bony resection is regarded as the standard objective of reduction malarplasty. However, unnecessary bony resection may lead to various postoperative complications. Therefore, we suggest the use of reduction malarplasty without bony resection to achieve a similar narrowing effect of the facial width, based on radiographic analysis of malar arch movement.

Patients and Methods:
This retrospective study analyzed 48 patients with a wide midface who underwent reduction malarplasty between September 2018 and December 2019. We included 40 cases of advancement repositioning malarplasty (AR) without bony resection and 8 cases of setback reduction malarplasty (SR) with bony resection. The three-dimensional position of the malar arch expressed by coordinates (x, y, and z) on three-dimensional computed tomography scans was used to compare the positional change between the surgical methods. The paired t-test, Wilcoxon text, and independent t-test were used in data analysis, and statistical analysis was performed using SPSS 23.0 software.

Results:
Medial and superior movement of the freed malar arch segment was significantly different between AR and SR (P < 0.05). Although medialization and superiorization were not significantly different between AR and SR, there was a significant difference in anterior-posterior movement between AR and SR (P < 0.05).

Conclusion:
The radiologic analysis based on malar arch movement between AR and SR showed similar narrowing effects on medialization and superiorization of the malar arch regardless of bony resection. Therefore, the AR can be effectively applied in case of arch dominant type or malar asymmetry. In addition, further comprehensive study including analysis on movement of facial soft tissue following malar bony movement is expected based on this study in near future.
Reassessment of the Optimal Number of Examined Lymph Nodes in Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma
Authors: Malleo Giuseppe , Maggino Laura , Qadan Motaz , Marchegiani Giovanni , Ferrone Cristina R. , Paiella Salvatore , Luchini Claudio , Mino-Kenudson Mari , Capelli Paola , Scarpa Aldo , Lillemoe Keith D. , Bassi Claudio , Castillo Carlos Fernàndez-del , Salvia Roberto 
Published: November 2020

Objective:
The aim of this study was to reappraise the optimal number of examined lymph nodes (ELNs) in pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).

Summary background data:
The well-established threshold of 15 ELNs in PD for PDAC is optimized for detecting 1 positive node (PLN) per the previous 7th edition of the American Joint Committee on Cancer (AJCC) staging manual. In the framework of the 8th edition, where at least 4 PLN are needed for an N2 diagnosis, this threshold may be inadequate for accurate staging.

Methods:
Patients who underwent upfront PD at 2 academic institutions between 2000 and 2016 were analyzed. The optimal ELN threshold was defined as the cut-point associated with a 95% probability of identifying at least 4 PLNs in N2 patients. The results were validated addressing the N-status distribution and stage migration.

Results:
Overall, 1218 patients were included. The median number of ELN was 26 (IQR 17–37). ELN was independently associated with N2-status (OR 1.27, P < 0.001). The estimated optimal threshold of ELN was 28. This cut-point enabled improved detection of N2 patients and stage III disease (58% vs 37%, P = 0.001). The median survival was 28.6 months. There was an improved survival in N0/N1 patients when ELN exceeded 28, suggesting a stage migration effect (47 vs 29 months, adjusted HR 0.649, P < 0.001). In N2 patients, this threshold was not associated with survival on multivariable analysis.

Conclusion:
Examining at least 28 LN in PD for PDAC ensures optimal staging through improved detection of N2/stage III disease. This may have relevant implications for benchmarking processes and quality implementation.
The mechanotransduction protein STOML3 is required for functional plasticity following peripheral nerve regeneration
Authors: Haseleu Julia , Walcher Jan , Lewin Gary R. 
Published: November 2020

AbstractNerve regeneration is associated with plasticity of sensory neurons, so that even muscle afferents directed to skin form mechanosensitive receptive fields appropriate for the new target. STOML3 is an essential mechanotransduction component in many cutaneous mechanoreceptors. Here we asked whether STOML3 is required for functional and anatomical plasticity following peripheral nerve regeneration. We used a cross-anastomosis model adapted to the mouse in which the medial gastrocnemius nerve was redirected to innervate hairy skin previously occupied by the sural nerve. We recorded from muscle afferents innervating the skin and found that in wild-type mice their receptive properties were largely identical to normal skin mechanoreceptors. However, in mice lacking STOML3, muscle afferents largely failed to form functional mechanosensitive receptive fields, despite making anatomically appropriate endings in the skin. Our tracing experiments demonstrated that muscle afferents from both wild-type andstoml3mutant mice display remarkable anatomically plasticity, forming new somatotopically appropriate synaptic terminals in the region of the dorsal horn representing the sural nerve territory. The dramatic reduction in stimulus evoked activity from the cross-anastomosed gastrocnemius nerve instoml3mutant mice did not prevent central anatomical plasticity. Our results have identified a molecular factor that is required for functional plasticity following peripheral nerve injury.
Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
Authors: Martín Guiomar , Márquez Yamile , Mantica Federica , Duque Paula , Irimia Manuel 
Published: November 2020

AbstractBackgroundAlternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron retention that modulate gene expression. However, a comprehensive study contrasting stress-response and tissue-specific AS patterns and directly comparing them with those of animal models is still missing.ResultsWe generated a massive resource for A. thaliana (PastDB; pastdb.crg.eu), comprising AS and gene expression quantifications across tissues, development and environmental conditions, including abiotic and biotic stresses. Harmonized analysis of these datasets revealed that A. thaliana shows high levels of AS (similar to fruitflies) and that, compared to animals, disproportionately uses AS for stress responses. We identified core sets of genes regulated specifically by either AS or transcription upon stresses or among tissues, a regulatory specialization that was tightly mirrored by the genomic features of these genes. Unexpectedly, non-intron retention events, including exon skipping, were overrepresented across regulated AS sets in A. thaliana, being also largely involved in modulating gene expression through NMD and uORF inclusion.ConclusionsNon-intron retention events have likely been functionally underrated in plants. AS constitutes a distinct regulatory layer controlling gene expression upon internal and external stimuli whose target genes and master regulators are hardwired at the genomic level to specifically undergo post-transcriptional regulation. Given the higher relevance of AS in the response to different stresses when compared to animals, this molecular hardwiring is likely required for a proper environmental response in A. thaliana.
Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19
Authors: Sharma Abhay 
Published: November 2020

AbstractEpidemiological and clinical evidence suggests that Bacille Calmette-Guérin (BCG) vaccine induced trained immunity protects against non-specific infections. Multiple clinical trials are currently underway to assess effectiveness of the vaccine in the coronavirus disease 2019 (COVID-19). However, the durability and mechanism of BCG trained immunity remain unclear. Here, an integrative analysis of available epidemiological transcriptomic data related to BCG vaccination and respiratory tract viral infections, and transcriptomic alterations reported in COVID-19 is presented toward addressing this gap. Results suggest that the vaccine induces very long-lasting transcriptomic changes that, unsurprisingly, mimic viral infections by upregulated antiviral defense response, and, counterintuitively. oppose viral infections by downregulated myeloid cell activation. These durability and mechanistic insights have immediate implications in fight against the COVID-19 pandemic.
A polyglutamine domain is required forde novoCIZ1 assembly formation at the inactive X chromosome
Authors: Sofi Sajad , Williamson Louisa , Turvey Gabrielle L. , Scoynes Charlotte , Hirst Claire , Godwin Jonathan , Brockdorff Neil , Ainscough Justin , Coverley Dawn 
Published: November 2020

SummaryCIP1-interacting zinc finger protein 1 (CIZ1) forms large assemblies at the inactive X chromosome (Xi) in female fibroblasts in anXistlncRNA-dependent manner. Here we address the requirements for assembly formation, and show that CIZ1 interacts directly withXistvia two independent domains in its N- and C-terminus. Interaction withXistrepeat E, assembly at Xi in cells, and the complexity of self-assemblies formedin vitro,are all modulated by alternatively-spliced exons that include two glutamine-rich prion-like domains (PLD1 and PLD2), both conditionally excluded from the N-terminal domain. Exclusion of PLD1 alone is sufficient to abrogatede novoestablishment of new CIZ1 assemblies and Xi territories enriched for H3K27me3 in CIZ1-null fibroblasts. Together the data suggest that PLD1-driven CIZ1 assemblies form at Xi, are nucleated by interaction withXistand amplified by multivalent interaction with RNA, so implicating a polyglutamine tract in the maintenance of epigenetic state.
Seven new metal–organic frameworks assembled from semi-rigid polycarboxylate and auxiliary N-donor ligands: syntheses, structures and properties
Authors: Zhang Xiaoyu , Yang Qinglin , Yun Meng , Si Changdai , An Ning , Jia Meimei , Liu Jiacheng , Dong Xiuyan 
Published: November 2020

Seven new metal–organic frameworks (MOFs), namely, [Zn2(L
1)(H2O)3]
n
(1), [Zn2(L
1)(dib)(H2O)2]
n
(2), {[Zn2(L
1)(4,4′-bipy)(H2O)2]·H2O}
n
(3), [Cd2(L
1)(1,10-phen)]
n
(4), [Ni2(HL
1)(4,4′-bipy)(μ3-OH)(μ2-H2O)]
n
(5), {[Co4(L
1)(4,4′-bibp)3]·(4,4′-bibp)3}
n
(6), and [Co2(L
2)(4,4′-bibp)2(H2O)]
n
(7), where H4
L
1 and H4
L
2 are semi-rigid 3-(3,5-dicarboxylphenoxy)phthalic acid and 4-(3,5-dicarboxylphenoxy)phthalic acid, respectively, and 4,4′-bipy is 4,4′-bipyridine, dib is 1,4-bis(1H-imidazol-1-yl)benzene, 1,10-phen is 1,10-phenanthroline and 4,4′-bipb is 1,4-bis(pyridin-4-yl)benzene, have been prepared under solvothermal conditions with ZnII, CdII, CoII and NiII ions in the presence of auxiliary N-donor ligands. The crystal structures and photoluminescence and magnetic properties of these compounds have been investigated. Compound 1 displays a 3,4,6-connected two-dimensional (2D) topology with a Schläfli symbol of (42.5)2(43.52.7)(45.56.63)2, and the 2D structure was further assembled to form a three-dimensional (3D) framework by intermolecular O—H...O hydrogen bonds. Compound 2 features a novel 3,3,4-connected structure and the point symbol is (4.102)(4.6.84)(62.8). Compound 3 exhibits a 3,4,6-connected 3-nodal net having a 3,4,6 T53 type topology, with the point symbol (4.62)2(42.64)2(42.68.82.103). Compound 4 shows a 2D→3D supramolecular structure formed by π–π stacking interactions. Compound 5 possesses a 3D framework with a tfz-d net topology. Compounds 6 and 7 are constructed from the same auxiliary ligand and metal salt at the same temperature, but with different main ligands and exhibiting different topologies. Compound 6 presents a 3D 4,6-connected topological network with a Schläfli symbol of (3.44.6)(32.44.56.63), while compound 7 has a 3D topological network with a Schläfli symbol of (412.616). Magnetic analyses indicate that compounds 5 and 7 show weak antiferromagnetic interactions.
A “knowledge value chain” framework for contractor organisations to maximise chances of winning tenders
Authors: Dewagoda Kaveesha Gihani , Perera B.A.K.S. , Senaratne Sepani 
Published: November 2020

PurposeKnowledge is a critical asset that places contractor organisations at a competitive advantage when they take part in competitive tendering. However, a dearth of literature exists on the mechanisms that contractor organisations can adopt to utilise knowledge to gain competitive advantage and win tenders through competitive tendering.Design/methodology/approachThe study adopted an interpretive stance with a qualitative approach that comprised a literature review, 15 expert interviews and three case studies. The literature review and expert interview findings were used to develop an intermediate framework of knowledge value chain (KVC), while the case study findings were used to develop the final KVC framework with the intermediate framework as the basis.FindingsThe study developed, in three distinctive steps, a KVC framework based on Powell's (2001) KVC for use by the tendering divisions/units of contractor organisations employing quantity surveyors (QSs) to handle tendering work and to increase their chances of winning tenders.Originality/valueThe study developed a KVC framework for the use of contractor organisations to maximise their chances of winning tenders in the field of quantity surveying.
Student work-placements from the company perspective: a case study
Authors: Ferrández-Berrueco Reina , Sánchez-Tarazaga Lucía 
Published: November 2020

PurposeThe aim of this paper is to report the motivations and perceived benefits of companies that collaborate with universities by offering student work-placement positions.Design/methodology/approachThe study follows a mixed methodology based on (1) a literature review on the topic, (2) a case study survey including companies that collaborate with one Spanish university in student work-placements and (3) meetings with collaborating companies in different countries and universities.FindingsThe most important reasons for collaborating in student work-placements were related to social duty, the opportunity of training students in company needs and as a source of staff recruitment. Conversely, the less rated motivators were improving the company's position within the sector, benefitting from university services and saving time in the selection of personnel.Research limitations/implicationsFuture research should include a bigger corpus of the number of universities and companies, as well as the type of collaborations with universities, in order to identify any resulting differences.Practical implicationsThe conclusions highlight the need to define/improve the mechanisms that contribute to a win-win context. This is the only way that collaboration can advance towards a genuine partnership that will provide an effective framework for universities and companies to effectively share the same objectives in training future employees.Originality/valueThese results are relevant because of the lack of quantitative and qualitative research on this topic.
Multiple burdens of stigma for prisoners participating in opioid antagonist treatment (OAT) programmes in Indonesian prisons: a qualitative study
Authors: Komalasari Rita , Wilson Sarah , Nasir Sudirman , Haw Sally 
Published: November 2020

Purpose
In spite of the effectiveness of opioid antagonist treatment (OAT) in reducing injecting drug use and needle sharing, programmes in prison continue to be largely stigmatised. This affects programme participation and the quality of programmes delivered. This study aims to explore how Indonesian prison staff and prisoners perceived and experienced stigma relating to prison OAT programmes and identify potential strategies to alleviate this stigma.

Design/methodology/approach
Three prisons in Indonesia were selected as part of a qualitative case study. Two of the prisons provided OAT, in the form of methadone maintenance treatment (MMT). Purposive and snowball sampling were used to recruit study participants. In total, 57 semi-structured interviews were conducted with prison governors, health-care staff, prison officers and prisoners. Prisoners included both participants and non-participants in methadone programmes. The data were analysed thematically.

Findings
MMT programme participants were perceived by both prison staff and other prisoners to be engaged in illicit drug use, and as lazy, poor, dirty and unproductive people. They were also presumed to be HIV-positive. These multi-layered, intersectional sources of (inter-personal) stigma amplified the effects on prisoners affecting not only their quality of life and mental health but also their access to prison parole programmes, and therefore the possibility of early release. In addition, organisational factors – notably non-confidential programme delivery and lack of both family and institutional supports for methadone prisoners – exacerbated the stigmatisation of MMT programme participants.

Practical implications
Effective strategies to alleviate stigma surrounding OAT programmes such as MMT programmes are urgently needed to ensure participation in and the quality of programmes in prisons.

Originality/value
Many prisoners reported experiencing stigma relating to their participation in MMT programmes in both the methadone prisons studied. They often emphasised the ways that this stigmatisation was amplified by the ways that MMT programme participation was associated with drug use and HIV infection. However, these intersecting experiences and concerns were not recognised by health-care staff or other prison staff. Effective strategies to alleviate stigma surrounding OAT programmes such as MMT programmes are urgently needed to ensure participation in and the quality of programmes in prisons.
Fatherhood escape as a significant feature of the gender contract of Russian men
Authors: Kashina Marina , Tkach Sergey 
Published: November 2020

PurposeThe purpose of this paper is to characterize such a feature of the gender contract of Russian men as fatherhood escape, as well as to determine the social consequences that it has for family relationship.Design/methodology/approachThe study was carried out in the design of qualitative sociology. The methodology is based on the theoretical construct of a gender contract, adapted to modern Russian society and the concept of social practices. The empirical base consists of six expert interviews with specialists in family psychology and conflictology.FindingsThe fatherhood escape in modern Russia is characterized by the depreciation of emotional labor; marking communications with children and caring for them as exclusively female activities; presentation of their employment in the public sphere as a legitimate reason for avoiding family problems; the active use by men of the technique of ignoring replicas of the interlocutor as a technique in communication with family members. This worsens the quality of intra-family communication, leads to the separation of family members from each other, especially children and leads to an increase in their deviant behavior.Research limitations/implicationsThe design of a qualitative study makes it impossible to assess the level of prevalence and severity of the phenomenon, this study is a pilot. Its purpose is to record the very fact of the existence of fatherhood escape in everyday family (social) practices. Subsequent studies should be able to show the relationship between fatherhood escape and domestic violence, as well as the role of this trait of the male gender contract in the reproduction of toxic masculinity.Originality/valueThe phenomenon of fatherhood escape and its social consequences in modern Russia is under-studied. This study contributes to the description of this phenomenon on Russian materials and also reveals some of the social consequences of this feature of the male gender contract, in particular its effect on intra-family communication, increasing the risk of deviant behavior of children and complicating the fulfillment by women of the “working mother” gender contract.
Closer to reality? The application of sequence analysis in crime linkage
Authors: Winter Jan-Martin , Rossi Gina 
Published: November 2020

Purpose
Traditional crime linkage studies on serial sexual assaults have relied predominantly on a binary crime linkage approach that has yielded successful results in terms of linkage accuracy. Such an approach is a coarse reflection of reality by focussing mainly on the outcome of an offence, neglecting the forceful differences due to the intricate offender-victim interaction. Only few researchers have examined sexual assaults through the lens of a sequence analysis framework. This paper aims to present the first empirical test of offence sequence-based crime linkage, moving beyond exploratory analyses.

Design/methodology/approach
Offence accounts from 90 serial sexual assault and rape victims from the UK were analysed and sequentially coded. Sequence analysis allowed to compare all offences combinations regarding their underlying sequence of events. The resulting comparison was transformed and plotted in two-dimensional space by multidimensional scaling analysis for a visual inspection of linkage potential. The transformed proximities of all offences were used as predictors in a receiver operating characteristic analysis to actually test their discriminatory accuracy for crime linkage purpose.

Findings
Sequence analysis shows significant discriminatory accuracy for crime linkage purpose. However, the method does perform less well than previous binary crime linkage studies.

Research limitations/implications
Several limitations due to the nature of the data will be discussed.

Practical implications
The practical limitations are as follows: the study is a potential practical value for crime analysts; it is a complimentary methodology for statistical crime linkage packages; it requires automated coding to be useful; and it is very dependent on crime recoding standards.

Originality/value
The exploratory part of this study has been published in a book chapter in 2015. However, to the best of the authors’ knowledge, the succinct test of crime linkage accuracy is the first of its kind.