bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with high‐dose antipsychotic prescriptions in outpatients with schizophrenia: An analysis of claims data from a Japanese prefecture
Authors: Takahashi Tatsuichiro , Otsubo Tetsuya , Kunisawa Susumu , Sasaki Noriko , Imanaka Yuichi 
Published: May 2020

AbstractBackgroundAntipsychotics are commonly prescribed in high doses in combination with multiple psychotropic drugs. This study focused on the high‐dose antipsychotic prescriptions in patients with schizophrenia, while aiming to identify their associations with patients’ characteristics and concurrent psychotropic prescriptions.MethodsThis cross‐sectional study used claims data from a prefecture in Japan, between October 2014 and March 2015, to investigate antipsychotic prescriptions in adult outpatients with schizophrenia. The objective variable was the presence/absence of a high‐dose prescription. The explanatory variables included sex, age (category), presence of comorbid conditions, and the use of psychiatrist's therapy.ResultsAfter exclusion, a total of 13 471 patients with schizophrenia were analyzed. The frequency of high‐dose prescriptions was higher in men, with chlorpromazine‐equivalent values highest in the age ranges of 45‐54 and 35‐44 years for men and women, respectively. Patients aged below 65 years with cerebrovascular diseases showed a decrease in high‐dose prescriptions. There was a high frequency of polypharmacy psychotropic drug use in combination with a high‐dose antipsychotic prescription in patients aged below 65 years.ConclusionHigh‐dose antipsychotics are often used in combination with several psychotropic agents in patients with schizophrenia. Our findings emphasize the need to evaluate the prescribing behavior of physicians to avoid high‐dose antipsychotic prescriptions for improved patient care.
A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib
Authors: Caldwell Kenneth J. , De La Cuesta Esther , Morin Cara , Pappo Alberto , Helmig Sara 
Published: May 2020

AbstractInfantile fibrosarcoma (IFS) is a rare pediatric cancer that typically presents early in life. Surgical resection is commonly curative; however, resection is sometimes not possible requiring additional multimodal treatment. IFS commonly harbors a fusion in one of the neurotrophic receptor tyrosine kinase (NTRK) genes. Larotrectinib, a highly selective inhibitor of tropomyosin receptor kinase (TRK), has been shown to be well tolerated and effective in children as young as 1‐month old. We report a case of IFS in a newborn treated with larotrectinib. The patient experienced a rapid clinical and radiographic response demonstrating the potential to treat newborns with larotrectinib.
Rare non‐Hodgkin lymphoma of childhood and adolescence: A consensus diagnostic and therapeutic approach to pediatric‐type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T‐cell lymphoma
Authors: Attarbaschi Andishe , Abla Oussama , Arias Padilla Laura , Beishuizen Auke , Burke G. A. Amos , Brugières Laurence , Bruneau Julie , Burkhardt Birgit , d'Amore Emanuele S. G. , Klapper Wolfram , Kontny Udo , Pillon Marta , Taj Mary , Turner Suzanne D. , Uyttebroeck Anne , Woessmann Wilhelm , Mellgren Karin 
Published: May 2020

AbstractPediatric‐type follicular (PTFL), marginal zone (MZL), and peripheral T‐cell lymphoma (PTCL) account each for <2% of childhood non‐Hodgkin lymphoma. We present clinical and histopathological features of PTFL, MZL, and few subtypes of PTCL and provide treatment recommendations. For localized PTFL and MZL, watchful waiting after complete resection is the therapy of choice. For PTCL, therapy is subtype‐dependent and ranges from a block‐like anaplastic large cell lymphoma (ALCL)‐derived and, alternatively, leukemia‐derived therapy in PTCL not otherwise specified and subcutaneous panniculitis‐like T‐cell lymphoma to a block‐like mature B‐NHL‐derived or, preferentially, ALCL‐derived treatment followed by hematopoietic stem cell transplantation in first remission in hepatosplenic and angioimmunoblastic T‐cell lymphoma.
The effect of maternal body mass index and gestational age on circulating trophoblast yield in cell‐based noninvasive prenatal testing
Authors: Panchalee Tachjaree , Vossaert Liesbeth , Wang Qun , Crovetti Brielle R. , McCombs Anne K. , Wapner Ronald J. , Van den Veyver Ignatia B. , Beaudet Arthur L. 
Published: May 2020

AbstractObjectiveTo examine the effects of maternal body mass index (BMI) and gestational age (GA) on the number of single circulating trophoblasts (SCT).MethodsMaternal blood was collected in 20 to 40 mL. All singleton pregnant women at any gestation were recruited. Trophoblasts were recovered by immunomagnetic enrichment and stained for cytokeratin and CD45. Candidate trophoblasts were identified by fluorescence microscopy.ResultsBlood samples were collected from 425 singleton pregnancies from April 2018 to December 2019. At least one candidate cell was identified in 88% (373/425). There was an inverse correlation between trophoblasts yield and increasing BMI (r = −0.19, P < .001). The mean ± SD number of trophoblasts/mL was 0.12  ± 0.22 in the underweight group (n = 5), 0.23 ± 0.25 in the normal weight (n = 169), 0.18 ± 0.19 in the overweight (n = 114), and 0.13 ± 0.15 in the obese (n = 109). Significantly more cells were identified in the normal weight than those in the obese (P = .001). In addition, the mean ± SD number of cells/mL was 0.21  ± 0.21 at GA of 10 to 14 weeks (n = 260), 0.14 ± 0.23 at GA ≥15 (n = 102) and 0.12 ± 0.12 at GA <10 (n = 63); P < .001.ConclusionThe lower number of SCT was identified from the samples of women with a high BMI. Cell recovery for SCT testing seems optimal at GA of 10 to 14 weeks, but earlier and later testing is still possible.
Reconstructing cold climate paleoenvironments from micromorphological analysis of relict slope deposits (Serra da Estrela, Central Portugal)
Authors: Nieuwendam Alexandre , Vieira Gonçalo , Schaefer Carlos , Woronko Barbara , Johansson Margareta 
Published: May 2020

AbstractThe paper focuses on analysis of macro‐ and micromorphological characteristics of relict slope deposits in Serra da Estrela (Portugal) to understand the significance of different slope processes and paleoenvironmental settings. Micromorphology is a useful sedimentology technique allowing significant advances compared to macroscopic techniques. Results show that different processes are involved in the development of the slope deposits, reflecting different environmental conditions. The main processes responsible for the emplacement of the relict slope deposits are solifluction, debris‐flow and runoff, but postdepositional changes are also present. Solifluction was identified in slope deposits between 650 and 1500 m a.s.l. The common microfeatures identified are circular arrangement of grains with a core grain, rounded vesicles, vertical grains, matrix deformations and fine‐grained deposits. Slope deposits above 1300 m a.s.l have a platy microstructure and coincide with the altitudinal range of the relict rock glaciers, indicating the elevation limit of permafrost. Below this altitude platy microstructures are less frequent. Slope deposits in north‐facing slopes were affected by frost‐induced processes in a seasonal frost regime, followed by a postdeposition illuvial phase. Debris‐flow and runoff were identified in slope deposits between 680 and 1260 m a.s.l. The common microfeatures are oblique grains, grain dumps, and coarse and fine grain lineations, and banded microstructures were identified in runoff processes. Debris‐flow deposits have a circular arrangement of grains without a core grain, identified in sediments in paraglacial and periglacial environments. The slope deposits show evidence of past periods of enhanced periglacial activity since the last glaciation until the Younger Dryas.
Patients eligible for modulator drugs: Data from cystic fibrosis registry of Turkey
Authors: Çobanoğlu Nazan , Özçelik Uğur , Çakır Erkan , Şişmanlar Eyüboğlu Tuğba , Pekcan Sevgi , Cinel Güzin , Yalçın Ebru , Kiper Nural , Emiralioğlu Nagehan , Şen Velat , Şen Hadice Selimoğlu , Ercan Ömür , Çokuğraş Haluk , Kılınç Ayşe Ayzıt , Al Shadfan Lina Muhammed , Yazan Hakan , Altıntaş Derya Ufuk , Karagöz Dilek , Demir Esen , Kartal Öztürk Gökçen , Bingöl Ayşen , Başaran Abdurrahman Erdem , Sapan Nihat , Çekiç Şükrü , Çelebioğlu Ebru , Aslan Ayşe Tana , Gürsoy Tuğba Ramaslı , Tuğcu Gökçen , Özdemir Ali , Harmancı Koray , Yıldırım Gonca Kılıç , Köse Mehmet , Hangül Melih , Tamay Zeynep , Süleyman Ayşe , Yüksel Hasan , Yılmaz Özge , Özcan Gizem , Topal Erdem , Can Demet , Korkmaz Ekren Pervin , Çaltepe Gönül , Kılıç Mehmet , Özdoğan Şebnem , Doğru Deniz 
Published: May 2020

AbstractBackgroundA better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor‐ivacaftor, tezacaftor‐ivacaftor, and elexacaftor‐tezacaftor‐ivacaftor. This cross‐sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs.MethodsData for age and genetic mutations from the Cystic Fibrosis Registry of Turkey collected in 2018 were used to find out the number of patients who are eligible for modulator therapy.ResultsOf registered 1488 CF patients, genetic analysis was done for 1351. The numbers and percentages of patients and names of the drugs, that the patients are eligible for, are as follows: 122 (9.03%) for ivacaftor, 156 (11.54%) for lumacaftor‐ivacaftor, 163 (11.23%) for tezacaftor‐ivacaftor, and 57 (4.21%) for elexacaftor‐tezacaftor‐ivacaftor. Among 1351 genotyped patients total of 313 (23.16%) patients are eligible for currently licensed modulator therapies (55 patients were shared by ivacaftor and tezacaftor‐ivacaftor, 108 patients were shared by lumacaftor‐ivacaftor and tezacaftor‐ivacaftor, and 22 patients were shared by tezacaftor‐ivacaftor and elexacaftor‐tezacaftor‐ivacaftor groups).ConclusionsThe present study shows that approximately one‐fourth of the registered CF patients in Turkey are eligible for modulator drugs. As, frequent mutations that CF patients have in Turkey are different from North American and European CF patients, developing modulator drugs effective for those mutations is necessary. Furthermore, as modulator drugs are very expensive currently, financial support of the government in developing countries like Turkey is noteworthy.
Making Progress Towards »Green« Propellants – Part II
Authors: Dejeaifve Alain , Sarbach Alexandre , Roduit Bertrand , Folly Patrick , Dobson Rowan 
Published: May 2020

AbstractNitrate‐ester based propellants require stabilisers in order to maintain good chemical stability and to prevent oxidation, chain scission, energy loss and uncontrolled heat generation that are caused by homolytic and heterolytic cleavage of the weakest nitrogen‐oxygen bond of the nitrate ester functional group. With REACH legislation (1907/2006), industry in Europe has made progress in using less toxic compounds, that are often more environmentally‐friendly. This work aims to go beyond REACH and to anticipate the inclusion of other molecules that produce non‐ or less toxic daughter products and that can fulfil their role in the propellant's formulation. This paper is the follow‐up to a first paper, presenting six families of “green” stabilisers, which are novel, environmentally friendly, efficient and readily available for use in nitrocellulose‐based compositions. In this article we present the validated lower temperature shelf life predictions for propellants containing the new stabilisers, using heat flow calorimetry (HFC). It will be necessary to modify AOP48 in the near future to be able to include these new stabilisers that provide much better performances than conventional ones (longer shelf lives of propellants) and are also respectful of the environment and human health.
Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation
Authors: Cargnoni Anna , Romele Pietro , Bonassi Signoroni Patrizia , Farigu Serafina , Magatti Marta , Vertua Elsa , Toschi Ivan , Cesari Valentina , Silini Antonietta R. , Stefani Francesca R. , Parolini Ornella 
Published: May 2020

AbstractGrowing evidence suggests a mechanistic link between inflammation and the development and progression of fibrotic processes. Mesenchymal stromal cells derived from the human amniotic membrane (hAMSCs), which display marked immunomodulatory properties, have been shown to reduce bleomycin-induced lung fibrosis in mice, possibly by creating a microenvironment able to limit the evolution of chronic inflammation to fibrosis. However, the ability of hAMSCs to modulate immune cells involved in bleomycin-induced pulmonary inflammation has yet to be elucidated. Herein, we conducted a longitudinal study of the effects of hAMSCs on alveolar and lung immune cell populations upon bleomycin challenge. Immune cells collected through bronchoalveolar lavage were examined by flow cytometry, and lung tissues were used to study gene expression of markers associated with different immune cell types. We observed that hAMSCs increased lung expression of T regulatory cell marker Foxp3, increased macrophage polarization toward an anti-inflammatory phenotype (M2), and reduced the antigen-presentation potential of macrophages and dendritic cells. For the first time, we demonstrate that hAMSCs markedly reduce pulmonary B-cell recruitment, retention, and maturation, and counteract the formation and expansion of intrapulmonary lymphoid aggregates. Thus, hAMSCs may hamper the self-maintaining inflammatory condition promoted by B cells that continuously act as antigen presenting cells for proximal T lymphocytes in injured lungs. By modulating B-cell response, hAMSCs may contribute to blunting of the chronicization of lung inflammatory processes with a consequent reduction of the progression of the fibrotic lesion.Significance statement The immunomodulatory features of amniotic cells can create a microenvironment able to limit the evolution of chronic inflammation to fibrosis. However, the immune modulation induced by amniotic mesenchymal stromal cells (hAMSCs) in models of fibrosis has yet to be elucidated. For the first time, this study shows that in bleomycin-challenged mice, hAMSCs control pulmonary B-cell recruitment, retention, maturation, and reduce the formation and expansion of lung lymphoid aggregates. By modulating B-cell response, hAMSCs hamper the self-maintaining inflammatory condition promoted by B cells in injured lungs and may contribute to limiting the chronicization of lung inflammation that evolves into the fibrotic lesion.
Picolinium‐Based Hydrophobic Ionic Liquids as Additives to PEG200 to Lubricate Steel‐Silicon Contacts
Authors: Donato Mariana T. , Caetano Fernando , Colaço Rogério , Branco Luís C. , Saramago Benilde 
Published: May 2020

AbstractThree new ionic liquids (ILs) containing the picolinium cation were synthesized using a more sustainable method based on microwave (MW) irradiation: 1‐hexyl‐2, 3 or 4‐picolinium trifluoromethanesulfonate ([C6‐x‐pic][TfO] where x=2, 3 and 4. The objective was, besides testing MW reactions with higher yields and lower reaction times comparing to conventional heating process, to assess the tribological behavior of these ILs as additives to base oil polyethylene glycol (PEG200). The friction coefficients (CoFs) for the pair silicon surface/steel sphere were compared to those obtained with other ILs based on the same anion. The ILs with cations containing one hexyl or butyl side chain led to lower CoFs, and [C6‐4‐pic][TfO] was the most efficient additive, which may be attributed to the cation symmetry. The roughness of the sliding surfaces was reduced after the tribological test using neat PEG200, but, when the additive [C6‐4‐pic][TfO] was added, the roughness was practically not affected. It seems that [C6‐4‐pic][TfO] adsorbs forming ordered layers that support the load together with the liquid film retained among the asperities of the opposing surfaces.
Interfacial Synthesis of Ag2S/ZnS Core/Shell Quantum Dots in a Droplet Microreactor
Authors: Zeng Yu‐Mei , Pan Liang‐Jun , Wang Ji , Fan Ya‐Ling , Shu Yun , Pang Dai‐Wen , Zhang Zhi‐Ling 
Published: May 2020

AbstractCoating a shell outside the silver chalcogenide quantum dots (QDs) is still difficult due to the large lattice mismatch between the core and the shell. In this work, benefited from the huge specific surface area of the droplets and the adsorption of nanoparticles (NPs) at the interface in a droplet microreactor, the problem was successfully solved. The Ag2S/ZnS core/shell QDs were rapidly synthesized by interfacial reaction for the first time in a droplet microreactor. By adjusting the concentration of precursors, the control of the shell thickness became workable. In addition, the quantum yield (QY) was improved approximately 20 times after growing a ZnS shell outside the Ag2S core. Besides, the effect of shell thickness on fluorescence was further studied, and it was found that only appropriate shell thickness could effectively improve fluorescence. The proposed method is novel, non‐toxic and controllable, providing a new way for the synthesis of core/shell QDs.
Synthesis and Biological Evaluation of 4/5‐Aroyl‐2‐aminoimidazoles as Microbial Biofilm Inhibitors
Authors: Rasapalli Sivappa , Reddy Sammeta Vamshikrishna , Singh Sarbjit , Golen James A. , Semerdzhiev Dimitar , Bo Yang , Silby Mark , Rao Reeta , Ali Akbar , Schiffer Celia A. , Savinov Sergey N. 
Published: May 2020

AbstractWe had earlier used Oroidin, a 2‐aminoimidazole‐pyrrole natural microbial biofilm inhibitor, as a structural prototype to develop its 4/5‐acyl modified form as an anti‐biofilm lead for further optimization. Herein, as a part of our efforts towards that direction, we report the design, synthesis, as well as anti‐bacterial, anti‐biofilm, and fungal adhesion inhibition activities of various 4/5‐aroyl‐2‐aminoimidazoles. These simplified Oroidin analogues are moderately active against bacterial biofilms and attest to the need for an aliphatic acyl linker that was part of the original 4/5‐acyl modified Oroidin lead. From our studies, protonation propensity of the 2‐aminoimidazole group of the series emerges as an important pre‐requisite for potent antibiofilm activity. Also, the fungal biofilm screening studies identified analogue 8 b as an active molecule.
Progress in Materials Development for the Rapid Efficiency Advancement of Perovskite Solar Cells
Authors: Chi Weiguang , Banerjee Sanjay K. 
Published: May 2020

AbstractThe efficiency of perovskite solar cells (PSCs) has undergone rapid advancement due to great progress in materials development over the past decade and is under extensive study. Despite the significant challenges (e.g., recombination and hysteresis), both the single‐junction and tandem cells have gradually approached the theoretical efficiency limit. Herein, an overview is given of how passivation and crystallization reduce recombination and thus improve the device performance; how the materials of dominant layers (hole transporting layer (HTL), electron transporting layer (ETL), and absorber layer) affect the quality and optoelectronic properties of single‐junction PSCs; and how the materials development contributes to rapid efficiency enhancement of perovskite/Si tandem devices with monolithic and mechanically stacked configurations. The interface optimization, novel materials development, mixture strategy, and bandgap tuning are reviewed and analyzed. This is a review of the major factors determining efficiency, and how further improvements can be made on the performance of PSCs.
Full Activation of Mn4+/Mn3+ Redox in Na4MnCr(PO4)3 as a High‐Voltage and High‐Rate Cathode Material for Sodium‐Ion Batteries
Authors: Zhang Wei , Li Huangxu , Zhang Zhian , Xu Ming , Lai Yanqing , Chou Shu‐Lei 
Published: May 2020

AbstractDeveloping high‐voltage cathode materials is critical for sodium‐ion batteries to boost energy density. NASICON (Na super‐ionic conductor)‐structured NaxMnM(PO4)3 materials (M represents transition metal) have drawn increasing attention due to their features of robust crystal framework, low cost, as well as high voltage based on Mn4+/Mn3+ and Mn3+/Mn2+ redox couples. However, full activation of Mn4+/Mn3+ redox couple within NASICON framework is still a great challenge. Herein, a novel NASICON‐type Na4MnCr(PO4)3 material with highly reversible Mn4+/Mn3+ redox reaction is discovered. It proceeds a two‐step reaction with voltage platforms centered at 4.15 and 3.52 V versus Na+/Na, delivering a capacity of 108.4 mA h g−1. The Na4MnCr(PO4)3 cathode also exhibits long durability over 500 cycles and impressive rate capability up to 10 C. The galvanostatic intermittent titration technique (GITT) test shows fast Na diffusivity which is further verified by density functional theory calculations. The high electrochemical activity derives from the 3D robust framework structure, fast kinetics, and pseudocapacitive contribution. The sodium storage mechanism of the Na4MnCr(PO4)3 cathode is deeply studied by ex situ X‐ray diffraction (XRD) and ex situ X‐ray photoelectron spectroscopy (XPS), revealing that both solid‐solution and two‐phase reactions are involved in the Na+ ions extraction/insertion process.
Overcoming Obstacles in Pathological Diagnosis of Pulmonary Nodules through Circulating Tumor Cell Enrichment
Authors: Yin Wei , Zhu Junjie , Ma Benting , Jiang Gening , Zhu Yuming , He Wei , Yang Yang , Zhang Zhemin 
Published: May 2020

AbstractWith the popularity of low‐dose computed tomography (LDCT) in clinical examination of the lung, the prevalence of pulmonary nodules has significantly increased, thus significantly improving the early diagnosis of lung cancer, but also potentially contributing to overtreatment. This study aims to develop a noninvasive method to assist in diagnosing the pulmonary nodules. To do so, 3798 patients are recruited from the Department of Thoracic Surgery at Shanghai Pulmonary Hospital and peripheral blood samples are collected from them before surgery. From these samples, circulating tumor cells (CTC) are isolated using folate receptor (FR) positivity, and then enriched and analyzed in relation to cancer gene expression, stage, and level of invasion. The average CTC concentration of patients with lung disease is 11.97 functional unit (FU) in a 3 mL sample of blood. FR‐positive CTC levels correlate with the expression of lung cancer driver genes tumor‐node‐matastasis (TNM) stage, and pleura invasion. The sensitivity of CTC levels to lung cancer diagnosis is 87.05%. Results from this study demonstrate that the determination of FR‐positive CTC concentration is a convenient and time‐saving strategy to improve the pathological diagnosis of pulmonary nodules.