bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional wheat bread with calcium chelate complexes
Authors: Kapustian A. , Cherno N. , Lebedenko T. 
Published: May 2020

Bakery products are promising objects for enrichment with functional food ingredients, as they are mass consumption products. The problem of hypo-elementosis in people makes it advisable to develop functional food ingredients based on easily digestible and safe forms of essential biometals, including calcium. In this study, it has been shown that wheat bread can be enriched with calcium chelate complexes. This functional food ingredient was obtained by complexation of Ca2+ with bioligands of probiotic origin, followed by immobilizing the complexes on dietary fiber of wheat bran. Mixed-ligand systems were obtained by combining a metabolite (lactic acid) and degradation products of peptidoglycans of Lactobacillus delbrueckii subsp. Bulgaricus B-3964. The peptidoglycans of the biomass autolysate were degraded by enzymatic hydrolysis with papain. This resulted in obtaining a mixture that contained amino acids, low molecular weight peptides, and muropeptides, in the concentrations 12.44 mg/cm3, 6.85 mg/cm3, and 2.76 mg/cm3, respectively. The nephelometric method has shown that this mixed-ligand system binds calcium ions in an amount of 18 mg/cm3. The soluble complexes obtained were immobilized on the dietary fiber to solve the problem of concentrating, drying, and dosing these ingredients. It has been proved that immobilization only occurs due to physical sorption that completely releases the active component from the dietary fiber matrix under conditions that simulate the gastrointestinal environment. The functional ingredient developed was added to the classic wheat bread recipe, where it replaced 1 %, 3 %, and 5 % of the flour. Bread was made without pre-fermentation to reduce the total production time and to prevent the ingredient’s biologically active components from being assimilated by yeast during long fermentation. The study of the experimental and control samples of wheat bread has shown that the introduction of chelate complexes of calcium immobilized on dietary fiber causes no deterioration of the physico-chemical parameters of the finished bread: they are all within the limits approved by the regulatory documentation. The sensory properties of the samples with 1 % and 3 % of flour replaced are close to those of the control sample. So 3 % of the ingredient is the recommended amount to be added, as it provides 98 % of the daily requirement of calcium as a functional ingredient and covers about 25 % of the daily allowance of dietary fiber.
Prevention of mineral metabolism of disorders in lactating rabbits
Authors: Korniichuk Y. V. , Grushanska N. H. , Kostenko V. M. 
Published: May 2020

Considerable damage to rabbit breeding is caused by the loss of production by eating or trampling newborn rabbits by their mothers. The main reason is the weakening of the organism due to deficiency of nutrients (high quality protein) and of biologically active substances in the diet. It is relevant today to search for non-toxic and highly effective complex preventive drugs, which have a positive effect on the mineral metabolism in animal organism. The research was carried out on the farm of Kyiv region. We studied the morphological parameters of blood by standard methods and the biochemical parameters of blood using semi-automatic biochemical analyzer with standard reagent kits. The content of chemical elements in blood plasma was investigated by the method of atomic emission spectrometry with inductively coupled plasma using Optima 2100 DV device. The paper presents the research on determining the biochemical status of an organism of lactating rabbits at the prevention of microelementosis using a new experimental eco-friendly drug. The content of total protein, albumin, glucose, total calcium, inorganic phosphorus, total bilirubin, urea, creatinine, TBA-active products, iron, manganese, copper, zinc, cobalt and activity of ALT, AST, ALP, GGT and Catalase in rabbits blood in the first,15th and 30th day for the use of the biologically active additive “Huminorm plus” is determined. In rabbit blood at the use of the “Huminorm plus” with water for watering for 15th days of the experiment, the content of hemoglobin was 1,2 times higher, phosphorus inorganic was 2.2 times higher, urea was 1.3 times higher, manganese was 3.6 times higher, cobalt was 2.6 times higher, cooper was 1.2 times higher and zinc was 1.6 times higher, compared to the first day of the experiment. In rabbit blood at the use of the “Huminorm plus” with feed for 30th days of the experiment, the number of red blood cells was determined to be 7 % higher, content of hemoglobin was 1.4 times higher, total protein was 1.2 times higher, urea was 1.3 times higher, calcium was 1.4 times higher, manganese was 3.1 times higher, zinc was twice higher, iron was 2.5 times higher, cobalt was 2.5 times higher, cooper was 1.7 times higher and alkaline phosphatase activity was 1.7 times lower, compared with the first day of experience. We defined the positive influence of the prophylactic drug on the indicators of hematopoiesis, metabolism of proteins and minerals in lactating rabbits. The development of ecofriendly, non-toxic substances for the prevention of mineral disbolism among rabbits is a promising area of research.
Physiological state of the broiler chickens organism on the background of combined stress and additive of humic acids and probiotic
Authors: Stoyanovskyy V. G. , Shevchuk M. O. , Kolomiiets I. A. 
Published: May 2020

The cultivation of broiler chickens is cost-effective given the high reproductive quality and growth rate of young growth at an early age. However, the management of the industry involves a number of technological operations that cause excessive stress on the adaptive systems, decrease the immunobiological reactivity of the bird organism, the development of stress and cause a decline in egg and meat productivity. Under these conditions, it is necessary to strengthen and stimulate the resistance of the body of the bird, to determine ways to eliminate the development of stressful states by providing full feeding. Therefore, the purpose of the study was to determine the morpho-functional status of the body of broiler chickens against the background of combined stress when included in the diet of humic acids “Reasil Humic Vet”, “Reasil Humic Health” and probiotics “Laktin”. For the 13th day of life, all livestock in a clinically healthy poultry were subjected to combined stress – revaccination (intranasal against Newcastle disease) + cold stress (for 60 min by conditioning the room and reducing the vivarium temperature by 5 °C). The study material was sampled 3 days after exposure to stress (corresponding to the anxiety stage), at 13, 20, and 26 days after exposure to stress (which accounted for the various stages of resistance stage development). It is established that the morpho-functional status of the body of broiler chickens on the background of combined stress is characterized at the stage of anxiety by reducing the concentration of hemoglobin and hematocrit by an average of 16.6 %, increasing the number of eosinophils and pseudo-eosinophils; at various stages of development of the stage of resistance – decrease in the number of red blood cells and hemoglobin concentration by 3.4–6.5 % against the background of increase of hematocritic value by 37.0 %, increase in the number of leukocytes by 17.2 % with a slight stabilization of respiratory and protective function of blood due to 26 days after stress. Influencing the formation of adaptive reactions of the body of broiler chickens of the experimental groups in the conditions of development of adaptation syndrome positive influence of the use of new biostimulants of natural origin “Reasil Humic Vet”, “Laktin” and “Reasil Humic Health” is shown, which is shown by the increase of hemoglobin concentration on average 13.0 % (P < 0.05), leukocyte count by 25.4 % (P < 0.05) due to lymphocytes 1.1 times (P < 0.05).
GANGGUAN ENDOKRIN PADA PASIEN THALASSEMIA Β MAYOR DI RSUP M DJAMIL PADANG
Authors: Ayudhia Shinta , Rini Eka Agustia 
Published: May 2020

Latar belakang. Gangguan endokrin merupakan komplikasi yang sering terjadi pada pasien thalassemia β mayor yang berefek pada kualitas hidupnya. Komplikasi ini terjadi karena penumpukan besi di dalam tubuh dan melibatkan organ seperti kelenjar endokrin sehingga pasien dapat mengalami hipotiroid, pubertas terlambat, perawakan pendek, gangguan insulin, usia tulang terlambat dan osteoporosis. Tujuan dari penelitian ini adalah untuk mengetahui kejadian endokrinopati pada pasien thalassemia β mayor di RSUP M Djamil Padang. Metode. Penelitian prospektif observasional terhadap pasien thalassemia β mayor yang di RSUP DR M Djamil pada bulan Januari – April 2018. Dilakukan pengumpulan data kadar feritin serum, tinggi badan, gula darah sewaktu, fungsi tiroid, status pubertas dan bone age. Data dianalisis secara univariat dan bivariat dengan menggunakan uji Chi square untuk mencari hubungan antara kadar feritin dengan perawakan pendek, status pubertas, usia tulang dan osteoporosis, dikatakan berhubungan apabila p value &lt; 0,05. Data dianalisis dengan menggunakan program SPSS. Hasil. Didapatkan 39 pasien thalassemia β Mayor, 3 orang menolak pemeriksaan, usia rata-rata 9,7 ± 3,9 tahun, 14 laki–laki (38,9%), 22 perempuan (61,1%), lama menderita thalasemia 5,6 ± 4,0 tahun. Perawakan pendek ditemukan pada 28 pasien (77,8%), tidak ada pasien yang menderita hiperglikemia. Dua orang (5,6%) mengalami hipotiroid, 4 dari 6 orang usia pubertas (66,67%) mengalami pubertas terlambat. Usia tulang retarded ditemukan pada 16 orang (44,4%) dan 3 orang (8,3%) mengalami osteoporosis. Tidak terdapat hubungan antara kadar feritin dengan perawakan pendek,status pubertas, usia tulang dan osteoporosis (p= 0,434 , p= 0,601 , p = 0,839 , p= 1.000). Kesimpulan. Gangguan endokrin terbanyak pada penelitian ini adalah perawakan pendek yaitu 28 pasien (77,8%). Tidak terdapat hubungan antara kadar feritin dengan perawakan pendek, status pubertas, usia tulang dan osteoporosis
Eksekusi Hak Tanggungan Terhadap Kredit Macet Bank
Authors: Yustiana Yustiana 
Published: May 2020

This study aims to determine the execution of mortgage rights if a bad credit occurs at Sengkang BRI Bank and also to determine the factors that influence if the execution of a non-performing loan mortgage is not implemented. Data collection methods used were interviews and literature study, then the data were analyzed descriptively. The results showed that the execution of mortgage rights in the case of bad credit at Bank BRI Sengkang was not yet effective. This is due to frequent negligence on the part of the Bank concerned in the procedure for credit disbursement, especially in credit agreements involving third parties. The factors that influence the execution of the mortgage are creditor and debtor factors. As long as there is an agreement between the two parties, there is a possibility that there will be no execution of the mortgage rights and if the execution is there the implementation will be carried out by peaceful execution.
Abstrak:Penelitian ini bertujuan untuk mengetahui eksekusi terhadap hak tanggungan bila terjadi terjadi kredit macet di Bank BRI Sengkang dan juga untuk mengetahui faktor-faktor yang mempengaruhi bila tidak dilaksanakannya eksekusi hak tanggungan kredit macet. Metode pengumpulan data yang digunakan adalah wawancara dan studi kepustakaan, kemudian data dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa eksekusi terhadap hak tanggungan bagi kasus kredit macet di Bank BRI Sengkang sebagian belum efektif. Hal ini disebabkan sering adanya kelalaian dipihak Bank yang bersangkutan dalam prosedur pencairan kredit, utamanya pada perjanjian kredit yang melibatkan pihak ketiga. Adapun faktor yang berpengaruh terhadap pelaksanaan eksekusi pada hak tanggungan adalah faktor kreditor dan debitor. Sepanjang ada kesepakatan antara kedua belah pihak, maka kemungkinan tidak akan terjadi eksekusi hak tanggungan dan kalaupun eksekusi itu ada maka pelaksanaannya akan ditempuh dengan cara eksekusi damai.
QSAR and Molecular Docking Studies of novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives as Potential Anti-Breast Cancer Agent
Authors: MOMOHJİMOH OVAKU İdris , STEPHEHE EYİJE Abechi , GİDEON ADAMU Shallangwa , ADAMU Uzairu 
Published: May 2020

Quantitative Structure Activity Relationship (QSAR) and molecular Docking studies were carried out on some novel compounds to generate a good QSAR models that relate the anti-breast cancer activity values with the molecular structure of the compounds. Genetic Function Algorithm (GFA) and Multiple Linear Regression Analysis (MLRA) were used to select the descriptors that were used to build the models. The best model built was found to have statistical validation values of squared correlation coefficient (R2) = 0.999, adjusted squared correlation coefficient ( = 0.998, cross validation coefficient = 0.998 and an external squared correlation coefficient = 0.879 which was used to confirm the validation of the model. The docking results showed that ligands 6 and 5 with binding energy (-9.2kcalmol-1 and -9.0kcalmol-1) respectively have the highest binding affinity when compared to the reference drug doxorubicin with binding energy (-6.8kcalmol-1). The stability and robustness of the built model showed that new anti-breast cancer agents can be design from these derivatives.
PENCARIAN JALUR TERDEKAT MENUJU RUMAH SAKIT DI KOTA BOGOR DENGAN MENGGUNAKAN ALGORITMA A*
Authors: , Erniyati , , Mulyati 
Published: May 2020

Pencarian jalur terpendek (shortesh path) merupakan salah satu solusi dalam pencarian suatu lokasi yang terdekat jika terdapat beberapa jalur yang dapat dilaluinya. Seperti halnya dalam pencarian rumah sakit di kota Bogor. Kota Bogor merupakan kota yang cukup luas dan memiliki jalur yang cukup banyak. Untuk mencapai rumah sakit yang dituju dibutuhkan informasi jalur terdekat guna meminimalisir biaya dan waktu yang lebih efisien. Ada beberapa algoritma yang bisa digunakan untuk pencarian jalur terdekat diantaranya yaitu algoritma A* (star), algoritma ini membuang langkah-langkah yang tidak perlu dengan pertimbangan bahwa langkah-langkah yang dibuang sudah pasti merupakan langkah yang tidak akan mencapai solusi yang diinginkan. Sistem ini selanjutnya dihubungkan dengan perangkat mobile yang berbasis android. Dengan menerapkan Algoritma A* (star) diharapkan dapat membantu dalam mencari dan menentukan lintasan terpendek sehingga didapat suatu jalur yang optimal untuk mencapai rumah sakit di Kota Bogor[TA1] [TA1]Belum terlihat tutjuan tahapan penelitian secara jelas
More on the interpretationof gingival bleeding index in gerontodentistry
Authors: Krajnov S. V. , Mikhalchenko V. F. , Popova A. N. , Firsova I. V. , Makedonova Yu. A. , Yakovlev A. T. 
Published: May 2020

Relevance. Symptom of bleeding in elderly age has a number of features of its manifestation, not fully associated with the severity of gingivitis and periodontitis. It is associated withpolymorbidity, polypragmasy, age-dependent involutional processes, as well as with immune system aging.Purpose. To study the influence of confounders on the interpretation of the gingival bleeding index in elderly patients with periodontitis.Materials and methods. The clinical and laboratory examination of 64 elderly patients with chronic generalized periodontitis, divided into 2 clinical groups, was conducted. The conventional treatment was administered in both patient groups. The patients in the second cohort, along with other medications, received Polyoxidonium.Each clinical group was divided into two subgroups: “a” and “b” (depending on the NSIADintake). The comparison group was also formed.It consisted of 25 patients of middle age with a similar degree of periodontitis. To assess the bleeding symptom, the Mühlemann-Cowell (1975) bleeding index was determined, as well as its reduction (%). The study of local immunity included gingival fluid sampling andestimation of IL-1β and IL-10 concentration (pg / ml). Clinical and laboratory examination of patients was carried out within the time constraints: before the start of treatment, after 7, 14, 21, and 30 days.Results. During the initial examination and statistical analysis of the bleeding index mean values in elderly patients, higher values of the coefficient of variation were found (25.07%) than in the comparison group (16.24%).It confirmed the influence of confounders over this indicator.Moreover, before treatment, in both groups, significant differences between subgroups remained (which verified the effect of non-steroidal anti-inflammatory drugs), which disappeared in the subsequent stages of the examination. In further periods of observation, a decrease in the bleeding index was found, as well as the concentration of cytokines, and in the 2nd group, these indicators were statistically significantly lower than in the 1st (p < 0.05).Conclusion. The study showed a more significanthaemostatic effect of immunomodulation compared with conventional treatment. When analyzing bleeding index in elderly patients, confounders must be considered, otherwise, the findings, which do not fully correspond to the level of inflammation in the marginal periodontium, will be incorrectly interpreted.
Evaluation of gingival microcirculation in localized periodontitis of traumatic etiology
Authors: Smirnova A. V. , Kakabadze N. I. , Kuzmina D. A. 
Published: May 2020

Relevance. The indispensable study of blood microcirculation of periodontal tissues in patients with localized periodontitis of traumatic etiology (LPTE) alongside with the assessment of the somatic status lets determine the degree of adaptive capacity of the organism. Laser Doppler flowmetry (LDF) allows noninvasively identify preclinical changes in the periodontal blood microcirculation and observe periodontal status at any treatment phase aiming at the confirmation of effectiveness of undertaken measures.Purpose. The objective of this work is to evaluate periodontal blood microcirculation in LPTE for existing latent vascular flow changes and adaptation features.Materials and methods. LDF measurements of periodontal blood microcirculation in 169 patients with mild and medium LPTE, conducted relaxed and with the use of functional cold test, were done.Results. A decrease in the number of functioning capillaries in periodontal tissues (expressed in a decrease of the integral index of microcirculation), a decrease in blood flow variability (σ-standard deviation) and the stress of the functioning of the regulatory blood microcirculation (Cv) were found. Due to outcomes, it was registered that in mild and medium severity LPTE, normal reaction of adaptation detected at 69.6% and 43.4% cases, respectively, in the remaining cases reaction of intense adaptation and unsatisfactory response adaptation (only if the moderate degree of LPTE) were fixed.Conclusion. Latent periodontal vascular flow changes and also adaptation characteristics are closely related with the somatic state of the body, in particular with the presence of cardiovascular disease in a group of patients.
Mubahın Şer’î Hüküm Olup Olmaması ile İlgili Yaklaşımlar ve Bunun Mubahın Sınırlandırılması ile İlişkilendirilmesi
Authors: YILMAZ İbrahim 
Published: May 2020

İslâm hukuk
metodolojisinde hükmün tanımı ile
ilgili biri kaynağını, diğeri muhatabını esas alan iki temel yaklaşım vardır.
Kaynağını esas alan yaklaşıma göre hüküm Şâri’in hitabı, muhatabını esas alan
yaklaşıma göre ise hüküm Şâri’in hitabının sonucudur. Her iki yaklaşıma göre de
hükmün tanımında biri “talep/iktizâ”, diğeri “tahyîr/muhayyerlik” olmak üzere
iki temel kavram yer almaktadır. Hükmün tanımında yer alan “talep/iktizâ”
kavramı; farz/vacip, mendup, mekruh ve haram gibi şer’î hükümleri içermektedir.
“Tahyîr” ise mubah olan hükümleri ifade etmektedir. Klasik dönem İslâm hukuku metodolojisinde mubahın
mahiyetiyle ilgili; “teklîfî hüküm olup
olmaması”, “şer’î hüküm olup
olmaması”, “emredilmiş olup olmaması” ve “talep içerip içermemesi” gibi birçok
konu tartışılmıştır. Hiç şüphesiz bu konulardan en önemlisi, “mubahın şer’î hüküm olup
olmaması” hakkında cumhur ile Mu’tezilî âlimler arasında geçen tartışmadır. Cumhur,
mubahın teklîfî/şer’î hükümlerden biri olduğunu söylemektedir. Buna mukabil Mu’tezilî âlimlerden Abu’l-Kasim al-Belhî el-Kâ‘bî (öl. 319/911) ve onun taraftarları ise mubahın şer‘î bir hüküm olmadığını söylemektedirler. Diğer taraftan Mubahın şer’î hüküm olup
olmaması meselesi, “kamu otoritesinin mubahı/cevazı sınırlandırma
yetkisi” bağlamında son dönemlerde de tartışılmaya devam etmektedir. Nitekim
Osmanlı’nın son dönemlerinde Mansurizâde Said (1864-1923), kamu otoritesinin
mubahı sınırlandırması bağlamında “cevazın
ahkâm-ı şer’iyyeden olmadığına dair” makaleler yazmıştır. Günümüz İslâm
hukukçularından bazıları da Mansurizâde’nin görüşünü haklı bulmaktadır. Ancak
kanaatimizce bu iki konu, yani mubahın şer’î hüküm olması ile mubahın kamu
otoritesi tarafından sınırlandırılması arasında doğrudan bir ilişki
bulunmamaktadır.
التَّصويرُ البَيَانِيُّ في آياتِ القتالِ دِرَاسَةٌ فَنِّيَّةٌ
Authors: AMIN MOHAMED SOLIMAN Abdelkarim 
Published: May 2020

إنَّ التَّصوِيرَ هُو أهَمُّ
الأَدَوَاتِ الفَنِيَّةِ في تَشكِيلِ النُّصُوصِ الأدَبِيَّةِ- قَدِيمًا
وحَدِيثًا- فلا يُمكِنُ أن نَتَصَوَّرَ نَصًّا أَدَبِيًّا من غَيرِ صُورَةٍ، أو
نَستَسِيغَ قَصِيدَةً من دُونِ أن تَتَمَاهى في الصُّورَةِ، أو تَأخُذَ من
آلِيَاتِ التَّصوِيرِ بِطَرَفٍ، حَتَّى صَارتِ القَصِيدَةُ عِندَ البعضِ صُورَةً، وصارَ
الشِّعرُ جِنسًا مِنَ التَّصوِيرِ. فالصُّورةُ هي الشَّيءُ الثَّابِتُ في النُّصُوصِ
الأدبيَّةِ عبرَ العُصُورِ، ولِجَمَالِيَّاتِ التَّصوِيرِ الفنِّيِّ التي أَثَرٌ
في العقلِ والقلبِ معا، وقُدْرَةٌ على نَقلِ المعنى معَ التَّأثِيرِ في
المتَلَقِّينَ، اعتَمَدَ عليه القرآنُ في جُلِّ مَوضُوعَاتِهِ حَتَّى صَارَ
الملمَحَ الأسلُوبِيَّ الأسَاسِيَّ في النَّصِّ القرآنِيِّ الذي بَلَغَ حَدَّ
الإعجَازِ.

إنَّ لآياتِ القتالِ في القرآنِ
أَهمِّيَّةً تَنبُعُ من طبيعةِ الموضوعِ، وتأثيرِهِ على أرواحِ النَّاسِ
وممتلكاتِهم، وتنظيمِ العلاقةِ والمعاملةِ بين المسلمينَ وغيرِهِم، وبين المسلمين
بعضِهم ببعض؛ لذلكَ شغلت هذه الآياتُ مِساحةً كبيرةً من النَّصِّ القرآنيِّ، وكان
لِعلومِ البلاغةِ وعلى رأسها علم البيان دورٌ كبيرٌ في تشكيلِها وصِياغِتِها.

تَهدُفُ هَذِهِ الدِّرَاسَةُ إلى
بَيَانِ وتَحلِيلِ الصُّورةِ البَيَانِيَّةِ في آيَاتِ القِتَالِ، والكَشفِ عن
جَمَالِيَّاتِها، وطُرُقِ تَشكِيلِها، وتَأكِيدِ أَهَمِّيَّةِ التَّصويرِ في
القرآنِ؛ فجَاءتِ هذه الدِّرَاسَةُ في مُقَدِّمَةٍ و خمسة مَبَاحِثَ، هي: ١- مفهوم
الصورة وأهميتها وتشكيلها. 2- التَّشبِيه 3- الاستِعَارَةُ. 4- الكِنَايَةُ. 5-
الطِّبَاقُ والمقَابَلَةُ.
Stenotrophomonas maltophilia: Descripción de un agente altamente infeccioso
Authors: Daza Hernández Adriana Lisette , Prado Calleros Héctor Manuel , Contreras Muñoz Angélica 
Published: May 2020

Stenotrophomonas maltophilia es una bacteria oportunista que causa diversos tipos de infecciones asociadas a la atención sanitaria en pacientes debilitados, especialmente en aquellos que previamente han recibido antimicrobianos de amplio espectro. Stenotrophomonas maltophilia se posiciona hoy en día como un patógeno nosocomial de ámbito general, añadiéndose a otros multirresistentes como Staphylococcus aureus, Acinetobacter spp. y Pseudomonas aeruginosa.
Presentamos este caso dado que es el primero que encontramos en nuestro servicio, simulando una infección recurrente por micobacterias, con el objetivo de demostrar el protocolo utilizado para diagnóstico y tratamiento; Este germen es poco frecuentemente reportado, siendo todos en inmunosuprimidos o con tratamiento antibiótico prolongado. Este agente infeccioso debe considerarse e incluirse entre los diagnósticos diferenciales de conglomerados ganglionares abscedados. En pacientes con inmunosupresión sospechada o conocida es necesario descartar la presencia de microorganismos oportunistas, para poder proveerle un adecuado diagnóstico y tratamiento específico