bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Profiles of Brain and Pulmonary Metastatic Disease in Cancer of Unknown Primary
Authors: Bakow Brianna R. , Elco Christopher P. , LeGolvan Mark , Dizon Don , Ollila Thomas A. 
Published: April 2020

Abstract

Cancers of unknown primary (CUP) are histologically confirmed malignancies but for which further investigation cannot identify a primary site. Improvements in histopathologic modalities for diagnosis have lessened the frequency of CUPs to 3%–5% of all malignancies compared with historical estimates of 5%–10%. Despite this, there is an ongoing debate as to whether CUPs are malignancies where the primary is not found or if they are otherwise a fully separate entity. Improvements in molecular analysis holds promise for improved identification and treatment of CUPs with mixed preliminary results. Here we present a woman with CUP and metastases in her brain and lung. We performed genomic profiling to compare the molecular makeup of each site in order to establish treatment targets.

Key Points
Cancer of unknown primary remains a diagnostic and therapeutic challenge. Molecular analysis may provide improvements in diagnosis and novel treatment options. Different sites of metastatic disease have subtle variations in molecular profile. Sequencing of different sites may offer therapeutic options that are either already approved or available in clinical trial.
The Level of Student Literacy Towards The Sharia Cooperatives
Authors: Marlina Ropi , Juliana Juliana 
Published: April 2020

Abstract. This article is motivated by the wrong perception of the understanding and knowledge of Islamic cooperatives. The purpose of this study is to find out the level of student literacy in Islamic cooperatives. The method used is quantitative descriptive method. The number of research samples amounted to 70 active students of the Indonesian Education University representing each faculty. The results showed that students did not fully understand the development agreement used in Islamic cooperatives that is included in thecontract syirkah. However, in general students' literacy toward usury and the compatibility of Islamic cooperatives with Islamic principles is largely understood. The implication of this research shows that there is a need to increase literacy to students as younger generation more specifically about the existing contractual agreements in Islamic cooperatives. Keywords. Sharia Banking, Sharia Cooperative, Syirkah, Student Literacy
Traumatic Enucleation and Bilateral Colles’ Fracture in a 70 Year Old Farmer
Authors: Monsudi Kehinde Fasasi , Ayanniyi Abdulkabir Ayansiji , Danfulani Muhammed , Balarabe Hamza Aliyu 
Published: April 2020

Purpose: To report a case of traumatic enucleation and Colles’ fracture in a 70-year-old male farmer following a fall from a height.
Design: A case report.
Findings: Enucleated right eye and bilateral Colles’ fracture.
Practical implications: The attending health care personnel should do a complete assessment of a patient with a history of fall from a height to avoid missing important bodily injuries. Fall from height is a cause of avoidable blindness.
Originality: Rare original case of traumatic enucleation after a fall.
Training upcoming academicians through interviews of pharmacy resident teaching certificate leaders
Authors: Eddy Emily , Long Brittany , Peters Lindsey , Grundey Jennifer , Musser Michelle , Shaffery Karielle 
Published: April 2020

Background: Discovering methods of Residency Teaching Certificate Programs (RTCPs) will allow for collaboration in developing best practices to ensure both high quality of programming and outcomes for participants.
Objective: The primary objective of this project is to describe and compare how RTCPs are conducted in the state of Ohio. Secondarily, to identify current practices in assessing RTCPs in both programmatic effectiveness and individual resident teaching outcomes.
Methods: The seven coordinators of the seven Ohio RTCPs (n=7) were contacted via email and asked to participate in an IRB-approved interview, either in-person or telephonically. Standardized questions were developed to inquire about six categories of interest: demographics/background, administration/logistics, content, assessment of the resident, program financing, and program continuous quality improvement (CQI). All seven programs participated in interviews. Data was coded by multiple members of the research team for presentation in aggregate form.
Results: RTCPs include seminar days at the respective pharmacy colleges; however, the number, length, and content of seminars vary. The majority of programs (n=5) stated using inherited curriculum and materials passed down from previous coordinators. While each RTCP requires participants to submit a teaching portfolio, only three of seven programs assess the summative portfolios. All programs (n=7) award participants a certificate based on completion of requirements without a defined minimum performance standard. Two programs are collecting participant feedback after every session for CQI however no programs are completing an annual programmatic assessment of resident outcomes. The majority of coordinators (n=7) are interested in collaborating and sharing “best practices” between RTCPs in the state.
Conclusions: Although published and available resources exist surrounding the development and delivery of RTCPs, in Ohio, their use varies greatly. The most striking outcomes highlighted the lack of resident and program assessment of outcomes in RTCPs. The research has brought forth ideas of ways to improve these programs through resident assessment, program assessment and also leads to reflection and innovation around the best way to deliver these programs.
Establishing A Global EBP Tool to Measure Evidence-Based Practice Knowledge: Translating and Testing the French Version of EKAN
Authors: Nick Jan M. , Roberts Lisa , Adrien Farah Martine , Wonder Amy H. 
Published: April 2020

Background and PurposeGovernment and professional organizations around the world have issued a call for evidence-based practice (EBP), affecting nursing globally. This study aimed to establish a baseline measure of EBP knowledge in French-speaking, baccalaureate nursing students and test the psychometric performance of a newly translated instrument.MethodsFor the cross-sectional, descriptive, correlational study, 103 baccalaureate nursing students from Haiti were included in the analysis.ResultsRasch analysis showed strong evidence of validity (Weighted MS M = 984; Unweighted MS M = 1.01). Individual items showed item reliability (.94). The mean EBP knowledge score was 5.9 (SD = 1.93; Range = 2–10 points).ConclusionsThis study provides initial psychometric evidence for an EBP knowledge measure that can be used as a catalyst for research in 29 French-speaking countries.
Modélisation des interactions digestives et de la production de méthane chez les ruminants
Authors: SAUVANT D. , GIGER-REVERDIN S. 
Published: April 2020

L’adéquation des apports alimentaires aux besoins des animaux et la prévision précise de leurs réponses aux pratiques alimentaires nécessitent de quantifier les éventuelles interactions digestives (non-additivité des valeurs potentielles des aliments au sein d’un régime). Deux bases de données ont été constituées de manière indépendante pour modéliser les effets spécifiques du niveau alimentaire et de la proportion d’aliment concentré (PCO) sur la digestibilité de la matière organique (dMO) du régime, sur les pertes énergétiques aux niveaux fécal, urinaire et de la production de méthane afin d’en déduire les conséquences sur les valeurs énergétiques des rations. La première base de données, BOVIDIG, rassemble 571 expériences (1482 traitements) sur bovins avec des mesures de digestibilité in vivo de la matière organique et la seconde, RUMENER, 151 expériences (1021 traitements) avec des mesures du métabolisme énergétique sur bovins, ovins et caprins.
Les résultats issus de ces deux bases sont globalement cohérents entre eux : l’augmentation de NA se traduit par une diminution de la digestibilité de la dMO , ou de l’énergie, qui est en partie compensée par de moindres pertes d’énergie aux niveaux urinaire et du méthane. L’accroissement PCO dans la ration entraîne une augmentation de la dMO, d’autant plus importante que la fraction fourrage associée est peu digestible et le niveau alimentaire, faible. La production de CH4 répond de façon curvilinéaire à PCO. De ces résultats, il ressort que l’évaluation de l’impact énergétique des interactions digestives ne peut se faire que sur la base de la dMO.
Les équations proposées permettent d’estimer, à partir de critères alimentaires simples (NA et PCO), les corrections à apporter sur la valeur énergétique des rations des différentes espèces de ruminants. Ces corrections sont un peu plus importantes pour les rations moyennes que les corrections actuelles des systèmes INRA, mais elles sont du même ordre de grandeur pour les rations «intensives» à fortes valeurs de PCO et NA.
A Novel RP-HPLC-DAD Method Development for Anti-Malarial and COVID-19 Hydroxy Chloroquine Sulfate Tablets and Profiling of In-Vitro Dissolution in Multimedia.
Authors: DONGALA THIRUPATHI , Ettaboina Santhosh Kumar , Katari Naresh Kumar 
Published: April 2020

Abstract
Hydroxychloroquine sulfate is one of a large series of 4-aminoquinolines with antimalarial activity. Moreover, it is used for the treatment of rheumatoid arthritis. Sometimes Hydroxychloroquine sulfate is very effective for the treatment of autoimmune diseases. Based on the recent clinical experiments it is exploiting for the treatment of COVID-19, corona virus across the globe. A Reverse phase RP-HPLC method have been developed and validated as per the current ICH guidelines for estimation of Hydroxychloroquine sulfate tablets. As part of method validation specificity, linearity, precision and recovery parameters were verified. The concentration and area relationships were linear (R2 > 0.999), over the concentration range of 25 to 300 µg mL-1 for HCQ. The relative standard deviations for precision and intermediate precision were less than 1.5%. The proposed RP-HPLC generic method was applied successfully for evaluation of invitro dissolution profile with different pH conditions like 0.1N HCl, pH 4.5 Acetate buffer and pH 6.8 Phosphate buffers of US marketed reference product.
Design and Performance Evaluation of Rocket Stove for Cleaner Cooking in Rural Ethiopia
Authors: Mekonnen Bassazin Ayalew 
Published: April 2020

Abstract
Background:Many rural households in Ethiopia use traditional three-stone stove which has low energy efficiency and incurs indoor air pollution. Despite the fact that improved cook stoves design variability was seen between producers appears, they have received little or no promotion work to improvements over open fire stoves. The aim of this research work is manufacturing and experimentally testing of rocket stove to make sure that the new design provides a major improvement within the prevailing cooking practices.Method:The rocket stove was developed as per the Aprovecho Research Center (USA) design principle the article focused on investigating the thermal performance, the specific fuel and emission reduction potential of rocket stove as compared to the three-stone stove so as to confirm the duplicability. Water boiling test were conducted to investigate the performance of developed rocket stove and emission characteristics were investigated using portable Indoor Air Pollution (IAP) monitoring device. The parameters and protocols were adjusted as per the Aprovecho design principles.Results:The result revealed that the rocket stove has 29% thermal efficiency, 43% reduction in specific fuel consumption, 42% CO and 81% PM2.5 emission reduction as compared to the well-known utilized traditional three-stone stove in Ethiopia. The experiment revealed that, the rocket stove average emission is 1.8 µg/m3 CO and 10 µg/m3 PM2.5 respectively. The emissions characteristic of our stove satisfies the WHO indoor air quality standard.Conclusion:It can be concluded that the prototype rocket stove has a substantial improvement over the three-stone stove with regards to thermal efficiency, CO and PM2.5 emissions. Furthermore, the stove can be manufactured locally within required thermal efficiency and emission levels. Therefore, shifting to rocket stoves could reduce pressure on forests and mitigate indoor pollutants emission.
The ability of active fraction from Kappaphycus alvarezii (Doty) Doty Ex.P.C.Silva to Decrease Glucose Levels inhibit advanced Glycation End-Products (AGEs) Formation and RAGE (AGER) Gene Expression in Diabetic Rats
Authors: Wahyuning Mae Sri Hartati , Yulianti Evy - , Sunarti Sunarti - 
Published: April 2020

Abstract
Background. Kappaphycus alvarezii (Doty) Doty ex P.C.Silva is a widely used seaweed that has antioxidant and antiglycation activities. The purpose of this study was to examine the ability of active fraction from Kappaphycus alvarezii to decrease glucose level and inhibit glycation process. Methods. This study used bioassay-guided fractionation through three stages of the extraction, partition, and fractionation processes that were monitored using Thin Layer Chromatography and BSA-Glucose test. Inhibition of glycation was known by calculating percentage of inhibition and IC50. Selected active fraction was used for in vivo tests using 24 Wistar male rats. Measurement of glucose levels used GOD-PAP method, while levels of glycated albumin (GA) and Nε- (carboxymethyl) lysine (CML) were measured using ELISA. Analysis of RAGE gene expression used qPCR. Results Glycation test showed a significant difference (p < 0.05) between all treatments. Chloroform extract showed higher percentage of inhibition (62.4 ± 3.45%) with lower IC50 (0.33 ± 0.01 mg/ml) compared to methanol extract (0.52 ± 0.03 mg/ml). Methanol-soluble extracts had a higher percentage of inhibition (51.10 ± 1.64%) with IC50 0.45 ± 0.05 mg/ml compared to methanol-insoluble extract (1.25 ± 0.05 mg/ml). Fraction II had a higher percentage of inhibition (53.37 ± 1.92%) with IC50 0.12 ± 0.01 mg/ml compared to other fractions. Selected active fraction reduced blood glucose by 1.3% and 5.2% and CML levels by 50.6% and 42.4% at concentrations of 0.17 and 0.255 mg/ml in diabetic rats. RAGE gene expression was lower in the diabetic rat groups treated with active fraction compared to untreated diabetic group. Conclusions The active fraction has ability for reducing blood glucose, antiglycation, or reducing CML levels, and RAGE gene expression.
Combining chain link sampling with a community-based participatory action study of people who smoke drugs in two cities in British Columbia, Canada
Authors: Elhalifa Sulaf , Jozaghi Ehsan , Marsh Samona , Thomson Erica , Gregg Delilah , Buxton Jane , Jolly Ann 
Published: April 2020

Abstract
Background: The smoking of illicit drugs presents a serious social and economic burden in Canada. People who smoke drugs (PWSD) are at an increased risk of contracting multiple infections through risky drug practices. Peer-led harm reduction activities, and the resulting social networks that form around them, can potentially minimize the dangers associated with the smoking illicit drugs.Goal: The goal of this study is to examine the influence of peer-led harm reduction initiatives on drug behaviour by comparing the attributes and social networks of PWSD in two British Columbia cities with different harm reduction programs.Methods: Using community-based participatory action research (CBPAR) and respondent- driven sampling (RDS), individuals with lived drug experiences were employed from communities in Abbotsford and Vancouver as ‘peer researchers’ to interview ten contacts from their social networks. Contacts completed a questionnaire about their harm reduction networks.Results: We found that PWSD residing in Abbotsford were more likely to report engaging in harm-promoting behaviours, such as sharing, reusing, or borrowing crack pipes. However, PWSD in the Downtown Eastside Community (DTES) of Vancouver were more likely to report engaging in harm-reducing activities, such as being trained in naloxone use and CPR. These differences are likely linked to the greater availability of harm reduction programs in DTES compared to Abbotsford.
Characterization and equilibrium studies for the removal of methylene blue from aqueous solution using activated bone char
Authors: Inam Edu J. , Edet John Bassey , Akpan Patrick E. , Ite Kufre E. 
Published: April 2020

Abstract
The surface characteristics as well as adsorption potential of activated cow bone char for the removal of methylene blue (MB) from aqueous solution were investigated. Physical characteristics of the adsorbent revealed a large surface area, low pore volume, reduced ash and moisture contents, which have been identified as good adsorption characteristics. The surface of the adsorbent was predominated by mesopores with a few microporous structures as well as the presence of carbonates, phosphates, silicates and hydroxyl groups which are characteristic of the apatite phase. Adsorption efficiency for the removal of MB was observed to be influenced by pH, adsorbent dosage as well as initial dye concentrations. Equilibrium adsorption data was best described by the Freundlich isotherm with a good correlation coefficient suggesting multilayer adsorption of the dye molecules on the surface of the adsorbent. Based on the drive for reduced cost, removal efficiency and availability, activated carbon from cow bone could be a promising adsorbent for methylene blue-laden effluent that could be utilized in small and large industrial applications.
Effects of upper cervical translatoric mobilization on headache, quality of life, cervical mobility and pressure pain threshold in patients with cervicogenic headache: A randomized controlled trial.
Authors: Malo-Urriés Miguel , Tricás-Moreno José Miguel , Estébanez-de-Miguel Elena , Bueno-Gracia Elena , Fanlo-Mazas Pablo , Hidalgo-García César 
Published: April 2020

Abstract
Objective

The purpose of this study was to evaluate the effects of upper cervical translatoric spinal mobilization (UC-TSM) on headache, quality of life, cervical mobility and pressure pain threshold in subjects with cervicogenic headache (CEH).
Methods

Eighty-two volunteers (41.5 ± 15.3 years; 20 males and 62 females) with CEH participated in the study and were randomly assigned to control or treatment group. The treatment group received 3 sessions of UC-TSM and the control group remained the same sessions, in the same position and time but received no treatment. Primary outcomes were Headache Impact Test for headache-related quality of life and flexion-rotation test for upper cervical mobility. Secondary outcomes included intensity, frequency and duration of headache, general cervical mobility and pressure pain thresholds over cervical spine. They were measured at baseline, at the end of the treatment and one month after the intervention.
Results

UC-TSM group increased significantly headache-related quality of life (p < .001; d = .857). Headache intensity, frequency and duration improved in UC-TSM group (p = .000-.013), in contrast to control group which did not obtain significant changes (p = .234-.965). UC-TSM group presented significant increases in upper cervical mobility (p < .001). Between-group effect sizes were considered large at T1 (d = 0.90–1.21) and moderate to large at T2 (d = 0.78–1.17).
Conclusions

Three sessions of UC-TSM increased headache-related quality of life and upper cervical mobility in subjects with CEH. Intensity, duration and frequency of headache, cervical mobility and PPT also improved. Further research considering the limitations of the present clinical trial is required to confirm this tendency.
Analysis of differential gene expression of heart failure based on Gene Expression Omnibus database
Authors: Yan Haifeng , Wang Xianliang , Hou Yazhu , Yang Zhihua , Mao Jingyuan 
Published: April 2020

Abstract
Background

To screen and identify key genes involved in heart failure and explore underlying molecular mechanisms.
Methods

The expression profile of GSE26887 was downloaded from Gene Expression Omnibus (GEO), which contained 24 samples, including 19 left ventricle cardiac tissue of heart failure and 5 controls. The differentially expressed genes (DEGs) were obtained and got further analysis by bioinformatics methods. The DEGs and volcano plot were acquired with the use of ‘lima’ package in ‘R’ software and heat map was drawn through the ‘heatmap’ package. Gene ontology (GO) and pathway analysis of DEGs were performed by means of Database for Annotation, Visualization and Integrated Discovery (DAVID) and Kyoto Encyclopedia of Genes and Genomes (KEGG) online analyses, respectively. The DEGs interaction and network map were constructed through Search Tool for the Retrieval of Interacting Genes (STRING ) database and Cystoscope(v3.6.0)software.
Results

The transcriptome analysis of left ventricle cardiac tissue showed that 236 genes were differentially expressed between heart failure and control, of which 124 were significantly upregulated (P < 0.01) and 101 genes downregulated (P < 0.01). GO analysis uncovered that DEGs were enriched in extracellular space, extracellular matrix, extracellular matrix organization, cell adhesion, proteinaceous extracellular matrix and heparin binding. Thus, the function of extracellular matrix is mainly affected. The KEGG pathway enrichment indicated that the DEGs were involved in eight pathways, of these pathways, ECM-receptor interaction, Drug metabolism-cytochrome P450 and Pathogenic Escherichia coli infection are dominant. Protein-protein interaction (PPI) revealed the interactions of 30 protein products encoded of DEGs. Of the 30 protein products, the critical gene, called Interleukin-6 (IL6), was identified with the use of Cystoscope software.
Conclusion

Extracellular matrix and IL6 play an important role in the development of heart failure. Functional annotation and pathway analysis of these main genes were identified, which provide the basis for insight into the underlying pathogenetic mechanisms and predicting therapeutic targets of heart failure.