bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Approach for Measuring Spatial Similarity Among COVID-19 Epicenters
Authors: Charandabi Neda Kaffash , Sadeghi-Niaraki Abolghasem , Choi Soo-Mi 
Published: August 2020

Abstract
The world has been embroiled in a new epidemic known as COVID-19 since the beginning of 2020. Most countries and territories around the world are affected by the disease, and some cities have become known as epicenters due to high outbreak. The similarity of these cities can be examined within the Geographic Information System (GIS), based on various criteria. This study investigated the similarities between the eight cities of Wuhan, Tehran, Bergamo, Madrid, Paris, Daegu, New York, and Berlin in terms of the COVID-19 situation (target) in those locations based on socio-economic factors, weather, and demographic criteria. First, the factor and target layers were prepared in ArcGIS®10.6 software. For socio-economic data (such as: supermarkets, hospitals, metro stations etc.), the distance maps were classified with a fuzzy membership function. Weather and demographic criteria were also stored in the tables after normalization in the range of zero to one. In next step, the similar cities were identified using the similarity model and different distance metrics (Manhattan, Euclidean, Minkowski, Mahalanobis, Chebyshev, and Correlation). The results were aggregated using the Copeland method, due to the different outcomes of each metric. The most similar city was identified for each selected city and its similarity level was determined based on the criteria. Results indicated that pairs of similar cities are: Wuhan-Berlin, Tehran-Berlin, Daegu-Wuhan, Bergamo-Madrid, Paris-Mardid, and New York-Paris with a minimum and maximum similarity rate of 82.85% and 92.36%. For similar cities, the most similar factors among the socio-economic criteria are the distance from bus and metro stations; among weather, criteria are humidity and pressure; and among demographic criteria are male and female population ratios, literacy ratio, death ratio from asthma and cancer with a minimum and maximum difference of 0% and 64.94%.
Comparative Genomic Insights into the Longhorned Tick, Haemaphysalis Longicornis
Authors: Zhang Rui-Ling , Zhang Qian , Zhang Zhong 
Published: August 2020

Abstract
Background: The longhorned tick, Haemaphysalis longicornis Neumann, is widely distributed across temperate regions. It can parasitize terrestrial vertebrates, including birds and a large number of mammals. They are a concern in human and animal health notably for their potential to transmit infectious agents. Methods: Genome survey was investigated using GenomeScope v1.0.0 with a maximum k-mer coverage cutoff of 1,000. Non-redundant assembly was polished with Illumina short reads using two rounds of NextPolish v1.1.0. Genome completeness was assessed using BUSCO v3.0.2 pipeline analyses against arthropod gene set (n = 1, 066). Ab initio predictions were generated using BRAKER v2.1.5. Transcriptomic reads were mapped to the genome with HISAT2 v2.2.0 and assembled with StringTie v2.1.2. Gene functions were assigned against UniProtKB database using Diamond v0.9.24. Orthogroups of 16 Chelicerata species were inferred using OrthoFinder v2.3.8 and gene family evolution was estimated using CAFÉ v4.2.1. Gene families related to digestion and detoxification, i.e. cytochrome P450 (CYP), carboxyl/cholinesterase (CCE), glutathione-S-transferase (GST), ATP-binding cassette (ABC) transporter were annotated by searching in the genome assembly. Results: The final genome assembly has a size of 3.12 Gb, a scaffold N50 of 1.09 Mb, and captured 92.4% of the BUSCO gene set (n=1,066). Genome architecture pattern of the longhorned tick resembles another tick, Ixodes scapularis (Say), particularly in large size, highly repetitive DNA (~65%) and protein-coding genes (21,550). We also identified 5,601 non-coding RNAs with a high ratio of tRNAs (4,271). Gene family evolution revealed 350 rapidly evolving gene families. Combining function enrichment analyses of gene ontology (GO) and KEGG pathway, 255 families experiencing significant expansions mainly involves in cuticle synthesis, digestion and detoxification. Conclusions: The new genome assembly, annotation and comparative genomic analyses provide a valuable resource for insights into parasitic life mode of the longhorned tick.
STAT3 Regulates the Pathogenesis and Bone Mesenchymal Stem Cells Transplantation of Spina Bifida Aperta Through Caspase-8
Authors: Jiang mingyu , Dai Ji-cheng , Yin Ming-ying , Ren Ming-yong , Wu Nan , Gao Ying 
Published: August 2020

Abstract
Objective: To investigate the influence of signal transducer and activator of transcription-3 (STAT3) on spinal cord tissue grafts of rat fetuses with spina bifida aperta. In particular, we wished to determine if STAT3 would be related to the pathogenesis of spina bifida aperta (SBA) and permit increased survival of spinal cord transplants to improve therapeutic efficiency of cellular transplantation from 20-day pregnant (E20) rats. Method: Spina bifida aperta were induced with a single intragastric retinoic acid (140 mg/kg body weight) administration on E10. STAT3 and caspase-8 expression, caspase-8 positive cells by immunofluorescence on 14, 15, 16 and 17 day in spinal cord of rat fetuses with control group and spina bifida aperta group are analysed. The pregnant rats received fetal surgery and microinjection of Mesenchymal Stem Cells (MSCs) after STAT3 transfection on 16-day pregnant (E16), 17-day pregnant (E17) and 18-day pregnant (E18), P0, P1-6 and to P7-12 of cell passages as well as different injected cell number, then sacrificed on 20-day pregnant (E20) for spine sample collection. The Number of each group was not less than seven. The spinal cord samples were collected directly to detect survival rates of MSCs and caspase-8 expression. Results: The developmental change in caspase-8 expression of spina bifida aperta was notably increased to the top on E15 compared with no SBA fetuses with Retinoic Acid. STAT3 expression in SBA rat fetuses gradually decreased with embryonic development between E14 and E15, E15 dropped down to bottom. Specifically, the number of caspase-8 positive cells on E15 in spinal cord with SBA rat fetuses was the most; and from E16, the positive cells began to decrease. Compared with STAT3 non-transfection group, MSCs combined with STAT3 transfection on E18, P7-12 and medium injection cell number can statistically improve the success rate of transplantation. In addition, caspase-8 mRNA and protein levels were significantly decreased in STAT3 transfection transplantation contrast for SBA of cellular culture medium and STAT3 non-transfection transplantation. Conclusions: STAT3 may be associated with the pathogenesis of spina bifida aperta. Furthermore, MSCs transplantation after STAT3 transfection can increase survival rates and reduce apoptosis in the spinal column through caspase-8.
EEG-Based BCI System to Control Prosthesis's Finger Movements
Authors: Gannouni Sofien , Belwafi Kais , Aboalsamh Hatim , Alebdi Basel , Almassad Yousef , AlSamhan Ziyad , Alobaedallah Homoud 
Published: August 2020

Abstract
Background: The advances in assistive technologies will go a long way towards restoring the mobility of paralyzed and/or amputated limbs. In this paper, we propose a system that adopts the brain-computer interface ( BCI ) technology to control prosthetic fingers by thoughts. To predict the movements of each finger, a complex EEG signal processing algorithms should be applied in order to remove the outliers , to extract feature, to discriminate between the fingers and to control prosthesis's finger. The proposed method discriminates between the five human fingers. So a multi -classification problem based on ensemble of one class-classifier is applied where each classifier predicts the intention to move one finger. At the end, an adapted machine learning strategy is proposed to predict movements of multiple fingers at the same time. Results: The sensitive regions of the brain related to finger movements are identified and located. The proposed EEG signal processing chain, based on ensemble of one class-classifier, reach a classification accuracy of 81 \ % for five subjects according to the online approach. Unlike most of the existing prototypes that allow to control only one single finger and to perform only one movement at a time by the dedicated finger, our proposed system will enable multiple fingers to perform movements simultaneously. Despite that the proposed system classifies a five tasks, the obtained accuracy is too high compared to a binary classification system. Conclusion: The proposed system contributes to the advancement of a prosthetic allowing people with severe disabilities to do the daily tasks easily.
Hemorrhagic fever with renal syndrome with concurrent aortic dissection: a case report
Authors: Qiu Fengqi , Li Congcong , Zhou Jianya 
Published: August 2020

Abstract
Background

Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses presenting with high fever, hemorrhage, acute kidney injury. Microvascular injury and hemorrhage in mucus was often observed in patients with hantavirus infection. Infection with bacterial and virus related aortic aneurysm or dissection occurs sporadically. We present a previously unreported case of hemorrhagic fever with concurrent Stanford B aortic dissection.
Case presentation:

A 56-year-old man complained of high fever, generalized body ache, with decreased platelet counts of 10 × 10^9/L and acute kidney injury. The ELISA test for Hantaan virus of IgM and IgG antibodies were both positive. During the convalescent period, he complained sudden onset acute chest pain radiating to the back and the CTA revealed an aortic dissection of the descending aorta extending to iliac artery. He was diagnosed with Hemorrhagic fever with renal syndrome and Stanford B aortic dissection. The patient recovered completely after surgery with other support treatments.
Conclusion

We present a case of HFRS complicated with aortic dissection,and no study has reported the association of HFRS with aortic disease. However, we suppose that hantavirus infection not only cause microvascular damage but may be risk factor for acute macrovascular detriment. A causal relationship has yet to be confirmed.
CO2 Gasification Kinetics of Shenhua Bituminous Coal by Isothermal Thermo-Gravimetric Analysis
Authors: Zhang Jinzhi , Wang Zhiqi , Zhao Ruidong , Wu Jinhu 
Published: August 2020

Abstract
This research performed the gasification kinetics of three Shenhua coal under CO2 atmosphere using isothermal thermogravimetry. Results showed that isothermal gasification curves for three different coal samples revealed different gasification behaviour. Among the eleven kinetic models, A2 was the most suitable one to describe the gasification kinetics of three coal samples, because it can reproduce the experimental data very well with reasonable correlation coefficients. The activation energy for sample A, B and C were 95.9, 79.1, and 69.4 kJ mol-1, respectively. The activation energy decreased with the increase of the particle size. The compensation relationship was observed between activation energy and frequency factor, and the mathematical expression was lnA=0.1041 E+0.54028 with the correlation coefficients of 0.999.
Mathematical equations for pressure relief angle of protective seam inclination in outburst coalmine
Authors: Zhang Zhen , Liu Gaofeng , Ren Ting , Booth Patrick , Lv Runsheng , Lin Jia 
Published: August 2020

Abstract
Protective seam mining is one kind of most effective measure to reduce coal and gas outburst risk. The pressure relief angles along inclination (δm) are key parameters for evaluating the effect of protective seam mining. However, the numerical relation between δm and coal seam dip (a) is defined by discrete data and is difficult to determine δm accurately. In this study, the variations of δm with respect to seam dips are analyzed to derive analytical equations that can be used to accurately calculate δm. The relationship between δm and seam dip (a) can be expressed as parabolic or inverted parabolic curves. Mathematical equations for δm are derived by curve fitting technique. Furthermore, polynomial equations are determined as the most appropriate for δm calculation when the polynomial order is selected as 7, 6, 4 and 5 respectively. These derived equations are computationally solved and verified using actual and field test data of δm. with satisfactory consistency and accuracy. The equations are suggested as supplement and improvement for Detailed Rules on Prevention of Coal and Gas Outburst.
Viral dynamic modeling of SARS-CoV-2 in non-human primates
Authors: Gonçalves Antonio , Maisonnasse Pauline , Donati Flora , Albert Mélanie , Behillil Sylvie , Contreras Vanessa , Naninck Thibaut , Marlin Romain , Solas Caroline , Pizzorno Andres , Lemaitre Julien , Kahlaoui Nidhal , Terrier Olivier , Fang Raphael Ho Tsong , Enouf Vincent , Dereuddre-Bosquet Nathalie , Brisbarre Angela , Touret Franck , Chapon Catherine , Hoen Bruno , Lina Bruno , Rosa-Calatrava Manuel , Lamballerie Xavier de , Mentré France , Grand Roger Le , Werf Sylvie van der , Guedj Jeremie 
Published: August 2020

Abstract
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques infected with 106 pfu of SARS-CoV-2 for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large daily viral production (>104 virus) and a within-host reproductive basic number of 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly cleared with a half-life of 9 hours, with no significant association between cytokine elevation and clearance. Translating our model to the context of human-to-human infection, human mild infection may be characterized by a peak occurring 4 days after infection, a viral shedding of ~11 days and a generation time of 4 days. These results improve the understanding of SARS-CoV-2 viral replication and better understand the infection to SARS-CoV-2 in humans.
The Effect of Structural and Environmental Changes on Litter Decomposition of in Pinus Sylvestris Stands
Authors: Çömez Aydın , Güner Şükrü Teoman , Tolunay Doğanay 
Published: August 2020

Abstract
Background: Decomposition of litter has an important role in primary production with its influence on nutrient release for plant uptake and carbon flux in forest ecosystems. Thus, understanding the effects of the intervention on litter decomposition is crucial for sustainable forest management. In this study, the effect of structural change and facing slope on litter decomposition in Scots pine stands (Pinus sylvestris L.) were investigated.Results: The decomposition rate of litter decreased as the stand age increased. Litter decomposed more rapidly on northern slopes than southern slopes. Cutting caused to accelerate the decomposition at a rate of up to 58% depending on its intensity. The k values were found to fluctuate though the time from 0.189 in moderately dense canopied stands to 0.317 in open canopied over-mature stands. Stand basal area, incubation time, and remaining carbon concentration of the litter accounted for 75% of the variation in the decomposition constant. Conclusions: Cutting-induced stand structural changes affected the litter decomposition process in forest ecosystems due to the micro environmental change as well as the change in litterfall composition and chemistry. Heavy treatments can change the litter decomposition process drastically, while moderate thinning may not have a clear effect in the long run. The stand specific k value should be considered to use in forest carbon models for more accurate estimation. Decomposition constant should be calculated by considering stand structure and incubation time of at least 1050 days. Besides, due to the significant effect of canopy closure on decomposition rate, stand specific or recalculated k constants according to stand basal area, incubation time, and remaining carbon concentration of the litter should be recommended to use in forest carbon models for more accurate carbon budget estimation.
The Functional Characterization of Phosphorylation of Tristetraprolin at C-Terminal NOT1-binding Domain
Authors: Hsieh Hsin-Hui , Chen Yen-An , Chang Yao-Jen , Wang Hsin-Hui , Yu Ya-Han , Lin Sheng-Wei , Huang Yin-Jung , Lin Steven , Chang Ching-Jin 
Published: August 2020

Abstract
Backgound: Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells and its mRNA destabilization activity is regulated by protein phosphorylation. Methods: We generated an antibody against phospho-Serine 316 located at C-terminal NOT1-binding site and examined TTP phosphorylation in LPS-stimulated RAW264.7 cells. Knockout of TTP in RAW264.7 cells using CRISPR/Cas9 gene editing was created to explore TTP functions. Results: We demonstrated that Ser316 was phosphorylated by p90 ribosomal S6 kinase 1 (RSK1) and p38-activated protein kinase (MK2), and dephosphorylated by Protein Phosphatase 2A (PP2A). Phosphorylation-mimic mutant of S316D resulted in dissociation with CCR4-NOT deadenylase complex through weakening interaction with CNOT1. Furthermore, Ser316 and serines 52 and 178 were independently contributed to CCR4-NOT complex recruitment in the immunoprecipitation assay using phosphor-mimic mutants. In RAW264.7 macrophages, TTP was induced and Ser316 was phosphorylated through RSK1 and MK2 by LPS stimulation. Knockout of TTP resulted in TNFα mRNA increased due to mRNA stabilization. Overexpression of non-phosphorylated S316A TTP mutant can restore TTP activity and lead to TNFα mRNA decreased. GST pull-down and RNA pull-down analyses demonstrated that endogenous TTP with Ser316 phosphorylation decreased the interaction with CNOT1. Conclusions: Our results suggest that the TTP-mediated mRNA stability is modulated by Ser316 phosphorylation to regulate the TTP interaction with CCR4-NOT deadenylase complex.
The Role of Intramedullary Nailing and Arthroplasty in the Treatment of Metastatic Carcinoma of the Proximal Femur: A Propensity Score-Matched Study
Authors: Li Kecheng , Kamar Santosh , Wang Cao , Li Su , Li Kun , Yuan Tao , Yang Yihao , Yang Jifei , Chen Jiahui , Tan Zunxian , Wang Rong , Yin Dezeng , Li Dongqi , Han Lei , Zhang Ya , Liu Shu , Ye Fan , Yang Zuozhang 
Published: August 2020

Abstract
Objectives: To investigate the selection, clinical efficacy and prognosis of surgical treatment for proximal femoral metastases and compare the effectiveness of the intramedullary nail and joint replacement to treat proximal femoral metastases.Methods: This study retrospectively enrolled 60 patients with proximal femur metastases treated from 2006 to January 2016. Outcomes among patients of the two surgical methods by collecting medical records, intraoperative blood loss, operative time, VAS score, MSTS score, ECOG score, postoperative complications, and overall survival time.RESULTS: The amount of bleeding and the average operation time were significantly different in the nailing group and the hip replacement group. The postoperative VAS score, MSTS score, and ECOG score were also significantly different.CONCLUSION: Intramedullary nailing is preferred for patients with a short survival time, and a better quality of life is achieved early in patients with a limited survival time. Hip replacement is appropriate for patients who are expected to have a long survival time.
OsPEX1, a leucine-rich repeat extensin protein, plays an important role in the regulation of caryopsis development in rice
Authors: Liu Shuchun , Ke Shanwen , Tang Guojian , Huang Dahui , Wei Minyi , Zhang Yuexiong , Qin Gang , Zhang Xiang-Qian 
Published: August 2020

Abstract
Rice caryopses are enclosed by the outside glumes. It is long been acknowledged that the size and dimension of the outer glume is the main determinant that dictates the caryopsis size. However, it is unclear whether the development of caryopsis is completely dependent on the size of the glume, or it can grow and expand autonomously in spite of the constraint of glume enclosure. Here we report the identification of a mutant line that produces normal-sized glumes with smaller mature caryopsis that do not fill up the entire glume cavity. The mutant phenotype is caused by ectopic expression of a leucine-rice repeat extensin gene, OsPEX1 . The caryopsis phenotype in pex1 was caused by a reduction in cell size. OsPEX1 is highly expressed in the developing caryopsis. Over expression of the OsPEX1 gene driven by a constitutive promoter recapitulates the mutant phenotype, confirming that the small caryopsis phenotype is caused by ectopic expression of the OsPEX1 gene. Our results suggest that caryopsis development can be genetically uncoupled from maternally controlled glume development.
Value of the Triglyceride Glucose index Combined with Body Mass index in Predicting non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes
Authors: Li Nong , Tan Huiwen , Xie Aixia , Li Cheng , Fu Xuan , Xang Weiting , Kirim Amina , Huang Xuefang 
Published: August 2020

Abstract
Objective: To explore the predictive value of the triglyceride glucose-body mass index (TyG-BMI) in relation to the occurrence of non-alcoholic fatty liver disease (NAFLD) in the Chinese population with type 2 diabetes (T2D). Methods: We selected 826 patients with T2D who were hospitalized at the Department of Endocrinology and Metabolism of Karamay People's Hospital from September 2016 to October 2018 for this research. The height, weight, fasting blood glucose, serum insulin, and lipid profiles of the subjects were collected. Stepwise logistic regression analysis was performed to calculate the triglyceride glucose (TyG) index, TyG-BMI, and the ratio of the insulin resistance index (HOMA-IR) to triglyceride high-density lipoprotein-cholesterol at risk for non-alcoholic fatty liver disease. The curve method was used to analyze its predictive value for non-alcoholic fatty liver. Results Results of the logistic regression analysis showed that the risk ratios of NAFLD were 6.54 (3.70-11.53) and 4.868 (2.576-9.200) for the TyG-BMI before and after correction. The area under the curve (AUC) for TyG-BMI was 0.727 (0.691–0.764), which was the highest among all the other parameters studied. Conclusion Compared with the TyG index, the TG/HDL-C, HOMA-IR, and the TyG-BMI are more effective predictors of NAFLD in T2D.
Rare Cardiac Myxoma with A Hard Texture: A Case Report
Authors: Xu Hongfei , Gu Yanjia , Ma Liang , Ni Yiming , Li Weidong 
Published: August 2020

Abstract
Background: Primary tumors of the heart are uncommon but not rare. Myxoma comprises 50% of all benign cardiac tumors in adults and 15% of such tumors in children. Cardiac myxoma is usually soft in texture and has a friable or villous surface, which tends to be associated with embolic events. It is also rare for myxoma to be full of calcium and metastatic bone deposits.Case presentation: We herein present a 58-year-old female patient with cardiac space-occupying lesion within the left atrium, and the lesion is lubricous and hard. Her only symptoms were hypertension, dizziness, and chest stuffiness. After surgical resection, we confirmed that the lesion was atrial myxoma by histopathology examination. The patient recovered uneventfully and was discharged. A 2-year follow-up exam showed no evidence of tumor recurrence.Conclusions: Cardiac myxoma is rare and has various clinical manifestations. It is usually friable and has an irregular surface, making embolic manifestations one of the most common complications. Consequently, immediate surgical excision is suggested upon diagnosis. In our case, the patient had a rare type of cardiac myxoma, which had a hard texture and lubricous surface. In our opinion, this case has a low risk of embolism. We prefer elective surgery rather than emergency surgery to perfect the preoperative examination for this kind of patient.