bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Multidimensional Predictors of Occasional and Recurrent Falls among Malaysian Community-Dwelling Older Adults
Authors: Ooi Theng Choon , Singh Devinder Kaur Ajit , Shahar Suzana , Rajab Nor Fadilah , Vanoh Divya , Sharif Razinah , Tan Maw Pin 
Published: October 2020

Abstract
Background: Falls incidence rate and comprehensive data on factors that predict occasional and repeated falls from large population-based studies are scarce. This study aimed to determine the incidence of falls and identify predictors of occasional and recurrent falls within the social, medical, physical, nutritional, biochemical, cognitive dimensions among community-dwelling older Malaysians. Methods: Data from 1,763 Malaysian community-dwelling older adults aged ≥60 years were obtained from the LRGS-TUA longitudinal study. Participants were categorized into three groups according to the presence of a single fall (occasional fallers), ≥two falls (recurrent fallers), or absence of falls (non-fallers) at an 18-month follow-up. Results: Three hundred and nine (17.5%) participants reported fall occurrence at 18-month follow-up, of whom 85 (27.5%) had two or more falls. The incidence rate for occasional falls and recurrent falls was 8.47 and 3.21 per 100 person-years, respectively. Following multifactorial adjustments, being single (OR: 5.310: 95% CI: 1.963-14.361), having higher depression score (OR: 1.123; 95% CI: 1.045-1.207), lower hemoglobin level (OR: 0.873; 95% CI: 0.797-0.956), and taking a longer time to complete the chair stand test (OR: 0.936; 95% CI: 0.881-0.995) remained independent predictors of occasional falls. While, having higher depression score (OR: 1.116; 95% CI: 1.010-1.233), being a stroke survivor (OR: 5.639; 95% CI: 1.502-21.129), having higher percentage of body fat (OR: 1.038; 95% CI: 1.010-1.067), lower hemoglobin level (OR: 0.853; 95% CI: 0.741-0.982), and taking longer time to complete the chair stand test (OR: 0.907; 95% CI: 0.824-0.998) appeared as recurrent falls predictors.Conclusions: Having depression, lower muscle strength and hemoglobin levels predict both occasional and recurrent falls among Malaysian community-dwelling older adults. This finding has implications for future research planning, which should aim to identify effective strategies for preventing falls among older adults by modifying these identified predictors.
Impact of Quality Healthcare Equipment And Physical Structure on Nhis-Hmo Outpatient Enrollees’ Perception In Lagos Hospitals
Authors: Mkperedem Abigail Affiong , Ogunlade Peter B , IGBOLEKWU Chisaa , Asamu Festus , Rasak Bamidele , ARISUKWU Ogadimma 
Published: October 2020

Abstract
This study assess enrollees’ perception of Health care facility’s (HCFs) physical structure and equipment quality across 9 accredited National health insurance/ Health maintenance organisation (NHIS-HMO) providing healthcare facilities within the 3 local government areas in Lagos, Nigeria. Anchored on the phenomenology of time consciousness and the filter theory of attention, the study methodology was triangulated using survey method and in-depth interview. A total of 252 questionnaires and 5 in-depth interviews (IDIs) were used to elicit data from selected respondents using simple random and convenient sampling technique. There were differences between the survey result and the in-depth interview (IDIs) responses in terms of structural awareness in contrast with access to treatment equipments. 61.1% of the respondents agreed that the physical environment of the HCF was conducive, 61.5% agreed to the presence of standard and functional medical equipments in the HCF. With regards to the quality rating, 55.1% perceived the quality of HCFs physical structure and equipment fairly positive while 30.6% of the respondents perceived it negatively. From the group comparisons, the Chi-Square results (P<0.01, χ2 (16) = 66.750) revealed significant correlations between quality of HCFs physical environment and equipment and enrollees perception. The Spearman’s correlation was also positive at .064. These findings indicate that the tangible aspects of healthcare service are significant in health outcomes and should be given priority to ensure consistency in quality health promotion.
Groundwater flow, heat flux, and permeability inferred from borehole temperature profile in Izu-Oshima volcano, Japan – Implications for subsurface hydrothermal system
Authors: Onizawa Shin'ya , Matsushima Nobuo 
Published: October 2020

Abstract
Groundwater flow velocity as well as conductive and convective heat fluxes were estimated using temperature profile data from a 1000 m–deep borehole in the central part of the Izu-Oshima volcano, Japan. Two depth intervals below groundwater level with upward groundwater flow patterns were examined assuming a one-dimensional vertical steady flow. The groundwater velocity and total heat flux were estimated to be 5.0–5.4×10-10 m/s and 0.54–0.59 W/m2, respectively, for the basement layer (Formation 4). For the shallower layer (Formation 2), both the upward velocity and heat flux were higher, indicating greater contributions of convective mass and heat transfer compared to those in the deeper layer. Furthermore, assuming that the upward flow was buoyancy-driven, vertical permeabilities of 2.8–5.1×10-15 and 1.7–3.1×10-16 m2 , respectively, were estimated for Formations 2 and 4. The temperature patterns of the lava-dominant region (Formation 3), sandwiched between Formations 2 and 4, suggested the occurrence of lateral cooler groundwater inflow in fractures. These results were used for understanding a hydrothermal system beneath the volcano. The total heat flux estimated for Formation 4 (0.54–0.59 W/m2) was nearly three times higher than the conductive heat flux in the northwestern coastal area, suggesting a higher heat supply below the central part of the volcano. A hydrothermal free convection system was inferred in Formations 2 and 3. In Formation 2, buoyancy-driven upward flow was enhanced because of the heat below and the higher permeability. Cooler groundwater was laterally supplied in lava fractures in Formation 3 to compensate for the mass loss by the upward flow at the bottom of Formation 2.
Multimorbidity and Leisure-Time Physical Activity Over The Life Course: A Population-Based Birth Cohort Study.
Authors: Feter Natan , Leite Jayne S , Umpierre Daniel , Caputo Eduardo L , Rombaldi Airton J 
Published: October 2020

Abstract
Background: We aimed to test which life course model best described the association between leisure-time physical activity (LTPA) and multimorbidity at age 55. We analyzed data from birth to age 55 using the database from the 1958 National Child Development Survey. Methods: Multimorbidity was considered as the presence of more than one chronic condition. LTPA was measured through questionnaires from 1965 (age 7) to 2013 (age 55), which were applied in eight different occasions. We compared the fit of a series of nested adjusted logistic regression models (representing either the critical, accumulation or sensitive period models) with a fully saturated model. Data were reported as odds ratio (OR) and 95% confidence interval (CI).Results: From the initial sample of 17,415 cohort members, 9,134 were interviewed in the latest sweep (49.2%). Men were more physically active than women at ages 11, 16, and 23 (p<0.001). LTPA every day in the week was more frequent in women than men in ages 33, 42, and 50 (p<0.001). The sensitive analysis revealed that LTPA during adolescence (OR: 0.72; 95% CI: 0.57, 0.92) and late adult life (OR: 0.71; 95%CI: 0.55, 0.91) have a stronger effect on the risk for multimorbidity at age 55 considering all other life stages in the model. Also, adolescence showed a critical independent effect on the risk for multimorbidity (OR: 0.74; 95%CI: 0.59, 0.92). No difference was found between those models. Conclusions: These data support the notion of a protective physical activity “legacy” at early ages of childhood against multimorbidity at older ages. We highlight the need for LTPA promotion through intervention tailored especially on schooling and older ages in order to reduce the burden of multimorbidity.
Cerebroplacental Ratio in The Prediction of Adverse Perinatlal Outcome in Postdte pregnancy - A prospective study
Authors: Ale Labake Victoria , Adewole Nathaniel David , Suleiman Bilal , Kolade-Yunusa Hadijat Oluseyi 
Published: October 2020

Abstract
BACKGROUND: Postdate pregnancies are associated with increased risk of fetal and maternal morbidity and mortality. The cerebroplacental ratio (CPR) is emerging as an important non-invasive tool to assess fetal wellbeing and predict adverse outcome in high risk pregnancies. The aim of this report was to evaluate the value of Doppler CPR in predicting adverse pregnancy outcome in the setting. METHOD: This was a prospective study of 97 pregnant women from 40 weeks of gestation. Fetal Doppler evaluation of the pulsatility index (PI) of the umbilical artery (UA) and middle cerebral artery (MCA) were done and the CPR calculated as MCA-PI/UA-PI. The women were followed up until delivery the following data collected: the Apgar score, birth weight and information about SCBU admission.RESULT: The women were aged 19 – 41 years (mean 30.22±4.8years) and the pregnancies were at 40 – 41+3 weeks. The mean UA-PI, MCA-PI and CPR were 0.83 ±0.16, 1.15±0.19 and 1.42 ± 0.31, respectively. Abnormal UA-PI, MCA-PI and CPR were associated with an increased risk of adverse perinatal outcome (relative risk of 4.72, 7.08 and 9.78 respectively). Abnormal UA-PI was associated with fetal distress, abnormal MCA-PI was associated with fetal distress, low Apgar score at 1minute and special care baby unit admission, and abnormal CPR was associated with fetal distress and low Apgar score at 1minute. CONCLUSION: CPR is a good predictor of adverse perinatal outcome in postdate pregnancy and is recommended as an adjunct in evaluation of fetal wellbeing in this setting and similar settings.
Giant Nodular Fasciitis Originating From The Humeral Periosteum: A Diagnostic Challenge
Authors: Yu Shili , Li Jian , Jia Meng , Sun Ping-Li , Gao Hongwen 
Published: October 2020

Abstract
Background: Nodular fasciitis (NF) is a self-limiting, benign, fibroblastic, and myofibroblastic tumor that mostly occurs in the subcutaneous superficial fascia, although there are reports of NF occurrences at atypical sites, such as intraneural and intra-articular locations. However, NF originating from the appendicular periosteum is extremely rare, and NF lesions usually are smaller than 4 cm. A large NF lesion of periosteal origin can be misdiagnosed as a malignant bone tumor and may cause overtreatment.Case presentation: This case report presents a large NF that originated from the humeral periosteum in an adult and was initially diagnosed intraoperatively as low-grade sarcoma, but later diagnosed as NF after post-resection histopathological evaluation. Furthermore, fluorescence in situ hybridization analysis revealed a USP6 gene rearrangement that confirmed the diagnosis. To the best of our knowledge, this is the first case of NF in the humeral periosteum.Discussion and Conclusions: NF poses a diagnostic challenge especially occurrences at rare sites as it is often mistaken for a sarcoma. Postoperative histopathological examination of whole sectionscan be combined with immunohistochemical staining and, if necessary, the diagnosis can be confirmed by molecular detection, and thus help avoid overtreatment.
Expression Profile of Micrornas (106b-3p, 130b-3, 145-3p and 199a-5p) in Urine and Serum Samples From Patients With the Diagnosis of Bladder Cancer
Authors: Kutwin Piotr , Borkowska Edyta Marta , Bogucka Paulina , Jablonowski Zbigniew 
Published: October 2020

Abstract
Background MicroRNAs (miRNA) are short, single stranded, non-coding RNAs that play an important role in controlling gene expression at the post-transcriptional stage. There is no bladder cancer marker that has been approved as an alternative for diagnostic cystoscopy and urine cytology so far, thus research for alternative, more sensitive, and less invasive methods of bladder cancer detection are being made. The aim of the study was to compare the relative expression levels of miRNAs in patients with bladder cancer.Materials and methods Urine and serum samples were collected from patients with the diagnosis of bladder cancer (NMIBC 71%, MIBC 29%). We assessed expression of 4 miRNAs (106b-3p, 130b-3, 145-3p and 199a-5p) using real-time PCR and double delta (ΔΔCt) method. The analysis was performed with the Mann-Whitney U test. Results miRNA 145-3p was significantly underexpressed in urine (p=0,0111) comparing with control group, whereas in serum we did not find relevant differences between groups (p=0,0903). Overexpression was observed for miRNA 199a-5p tested in urine (p=0,0262) and for miRNA 106b-3p for both urine and serum (p=0,0262 and p=0,0149 respectively) . For miR-130b-3 we did not find statistically significant differences neither for urine (p=0,6335) nor serum (p=0,2443).Conclusions A correlation between the relative levels of expression for miRNA 106b-3p, 199a-5p and miRNA 145-3p was detected. We also observed differences between the results obtained for urine and serum. In the content of urinary cancers diagnosis urine seems to be more useful material than serum. We plan to continue our studies assessing expression levels of miRNA 106b-3.
Comparing health insurance data and health interview survey data for ascertaining chronic disease prevalence in Belgium
Authors: Berete Finaba , Demarest Stefaan , Charafeddine Rana , Bruyère Olivier , Heyden Johan Van der 
Published: October 2020

Abstract
BackgroundHealth administrative data were increasingly used for chronic diseases (CDs) surveillance purposes. This cross sectional study explored the agreement between Belgian compulsory health insurance (BCHI) data and Belgian health interview survey (BHIS) data for asserting CDs.MethodsIndividual BHIS 2013 data were linked with BCHI data using the unique national register number. The study population included all participants of the BHIS 2013 aged 15 years and older. Linkage was possible for 93% of BHIS-participants, resulting in a study sample of 8474 individuals. For seven CDs disease status was available both through self-reported information from the BHIS and algorithms based on ATC-codes of disease-specific medication, developed on demand of the National Institute for Health and Disability Insurance (NIHDI). CD prevalence rates from both data sources were compared. Agreement was measured using sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) assuming BHIS data as gold standard. Kappa statistic was also calculated. Participants’ sociodemographic and health status characteristics associated with agreement were tested using logistic regression for each CD.ResultsPrevalence from BCHI data was significantly higher for CVDs but significantly lower for COPD and asthma. No significant difference was found between the two data sources for the remaining CDs. Sensitivity was 83% for CVDs, 78% for diabetes and ranged from 27% to 67% for the other CDs. Specificity was excellent for all CDs (above 98%) except for CVDs. The highest PPV was found for Parkinson’s disease (83%) and ranged from 41% to 75% for the remaining CDs. Irrespective of the CDs, the NPV was excellent. Kappa statistic was good for diabetes, CVDs, Parkinson’s disease and thyroid disorders, moderate for epilepsy and fair for COPD and asthma. Agreement between BHIS and BCHI data is affected by individual sociodemographic characteristics and health status, although these effects varied across CDs.ConclusionsNHIDI’s CDs case definitions are an acceptable alternative to identify cases of diabetes, CVDs, Parkinson's disease and thyroid disorders but yield in a significant underestimated number of patients suffering from asthma and COPD. Further research is needed to refine the definitions of CDs from administrative data.
Flood Inundation Simulations based on GSMaP Satellite Rainfall Data in Jakarta, Indonesia
Authors: Priyambodoho Bambang Adhi , Kure Shuichi , Yagi Ryuusei , Januriyadi Nurul Fajar 
Published: October 2020

Abstract
Jakarta is the capital of Indonesia and is considered as one of the most vulnerable cities to climate-related disasters, including flooding, sea-level rise, and storm surge, in the world. Therefore, the development of a flood-forecasting system for Jakarta is crucial. However, the accurate prediction of flooding in Jakarta is challenging because of the rapid flood-concentration time in highly urbanized basins and the shortage of rainfall data in poorly gauged areas. The aim of this study is to simulate flood inundation that occurred in recent years using global satellite mapping of precipitation (GSMaP) products. The GSMaP products (NRT and Gauge V7) were evaluated and compared with the observation data obtained hourly from five ground stations in the Ciliwung River Basin. In addition, a rainfall-runoff and flood inundation model were applied to the target basin. The results of the analysis showed that the GSMaP Gauge data were more accurate than the GSMaP NRT data. However, the GSMaP Gauge could not be used to provide real-time rainfall data and is, therefore, inadequate for real-time flood forecasting. We conclude that the GSMaP Gauge is suitable for replicating past flood events, but it is challenging to use the GSMaP NRT for real-time flood forecasting in Jakarta.
Clinical findings and molecular cytogenetic characterization of 19q13.42 microduplication: three cases report and literature review
Authors: Zhang Xinyue , Yue Fagui , Shi Qingyang , Jiang Yuting , He Jing , Li Leilei , Liu Ruizhi 
Published: October 2020

Abstract
BackgroundTrisomy 19q is a recognizable syndrome and associated with a wide spectrum of clinical phenotypes in clinic. The purpose of this study was to explore the prenatal phenotypes of 19q13.42 duplication, which was rarely reported in clinic. Case presentationThree pregnant women presenting diverse indications for prenatal diagnosis accepted amniocentesis: increased nuchal translucency (case 2) and high risk of trisomy 21 (case 1 and case 3). Case 1 and case 2 shared similar duplicated locus in the region of 19q13.42, encompassing part NLRP12 gene. Case 2 inherited the chromosomal duplication from the mother with normal phenotypes. Case 3 carried a 1.445Mb duplication in the 19q13.42q13.43 region. It was proposed that evolutionary duplication of NLRP12 gene could have a causative role in autoinflammatory diseases development. The genotype-phenotype correlation depends mainly on the duplicated size and functional genes involved, which is still yet to be determined. All pregnant women chose to continue the pregnancy and delivered healthy children with no apparent abnormalities.ConclusionsThe 19q13.42 microduplications in our study are the smallest fragments compared to previous literature. We delineated 19q duplication cases without structural ultrasound anomalies for the first time, which enriched the prenatal phenotypes of this chromosomal aberration. It was proposed that long term follow up analysis should be guaranteed till adulthood to determine whether there will be other emerging clinical symptoms and developmental-behavioral disorders for such carriers.
Pyramiding approach for development of blast and bacterial leaf blight resistant, and drought tolerant rice variety through marker-assisted selection
Authors: Akos Ibrahim Silas , Yusop Mohd Rafii , Ismail Mohd Razi , Ramlee Shairul Izan , Shamsudin Noraziyah Abd Aziz , Ramli Asfaliza Binti , Yusuff Oladosu , Muhammad Isma’ila 
Published: October 2020

Abstract
Rice ( Oryza sativa L) is an important cereal crop and staple food crop of the world, whose yield could be influenced by biotic and abiotic conditions, resulting in 1-100% yield losses depending on the incidences of diseases or severity of stress condition. The research was basically to identify the polymorphic markers at the target region (parental survey) and screened for selection of improved lines with multiple traits of resistance/tolerance to two or three of blast, bacterial leaf blight and drought tolerance. Three varieties were used; two high yielding varieties of Putra-1 and MR219-PL-137 resistant to blast and tolerant to drought respectively, and an IRBB60 bacterial leaf blight resistance variety. They were crossed to a common recipient parent (Putra-1) to produce two categories of F 1 hybrid as baseline for development of improved lines in three crossing methods which produced five populations (PB, PD, PBD, PDB, DPB) through marker-assisted pedigree selection. The populations were screened by genotyping using SSR markers to select lines polymorphic to parental cultivars and carrying the linked markers/QTLs for diseases resistance and drought tolerance: Blast resistance (RM6836 and RM8225), IRBB60 (RM224, RG136, RM122, RM21), MR219-PL-137 drought tolerance QTLs (RM236, RM520, RM511, RM1261). The results of gel electrophoresis agreed with the phenotyping results of the improved lines F 4 , F 3 (2), F 3 for single, double and three-way (and reciprocal) crosses respectively and also susceptible parent cultivars.
Phytochemical Evaluation of Hibiscus Sabdariffa Powder, Jam and Yoghurt
Authors: Hamwenye Karlin , Shindaadhi Helena , Sivhute Elizabeth , Hal Penny Hiwilepo-van , Samundengu Chinemba 
Published: October 2020

Abstract
BackgroundHibiscus sabdariffa is popularly known as food and herbal drink with numerous health benefits. The phytochemical compounds present in Hibiscus sabdariffa calyces are important in developing nutraceutical foods. In this study hibiscus jam and yoghurt were produced from dried hibiscus calyces’ powder.MethodsThe phytochemical content and antioxidant activity of these products were then analysed in terms of Total phenolic content (TPC), Total flavonoid content (TFC), Condensed tannins (CT) and DPPH Scavenging activity.ResultsThe results showed the presence of all phytochemical compounds (TPC, TFC, CT) and antioxidant activity in all Hibiscus sabdariffa products. The hibiscus calyces powder showed the highest phytochemical contents of 35.24 mg GAE. g -1 , 0.91 mg QE. g -1 , 2.85 mg CAE. g -1 and 48.2 % inhibition for TPC, TFC, CT and DPPH Scavenging activity, respectively. Hibiscus jam and Hibiscus yoghurt had phytochemical contents of 6.44 and 4.81 mg GAE. g -1 , 0.19 & 0.24 mg QE. g -1 , 1.40 & 0.66 mg CAE. g -1 and 26.2 & 39.3 % inhibition for TPC, TFC, TC and DPPH Scavenging activity, respectively.ConclusionsThe results of the current study showed that there is potential in using Hibiscus sabdariffa to develop functional foods.
Rapidly immobilization of simulated An3+ radioactive contaminated soil as glass-ceramics by microwave sintering
Authors: Luo Fen , Tan Haojie , Shu Xiaoyan , Miao Yulong , Chen Shunzhang , Yuan Beilong , Wang Lan , Xie Yi , Lu Xirui 
Published: October 2020

Abstract
The development of nuclear technology leads to the generation of radionuclide contaminated soils, which require efficient and rapid disposal methods. In this study, with microwave sintering method, the simulated radionuclides contaminated soils were successfully immobilized as glass-ceramics at 1200 °C with 30 min. The temperature effect, phase evolution, morphology, element distribution of simulated radioactive contaminated soil were investigated. The XRD results showed that Nd 3+ were immobilized into glass-ceramic phases with Nd 2 O 3 content increased up to 25 wt %. In addition, molecular dynamics simulation (MD) results showed the simulated radioactive contaminated soils were composed of [SiO 4 ] tetrahedron, and Si-O-Si bonds had an important effects on the glass structure forming.