bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angelica TatianaeBordz new distribution areas and study their coumarin derivatives
Authors: MAMMADOVA Husniya , MASHAYEVA Sevil 
Published: October 2020

There are nearly 4500 kinds of plants in Azerbaijan flora. Among these plants, the Apiaceae Lindl family takes a special place. This family is represented in the world with 400 genders. Among the genders including this family Angelica L. Gender attracts attention for its specific features. There are 115 types of this gender in the world (plant list 2013, 115), (plant list 2018, 116) [1]. In Azerbaijan flora, Angelica L. gender is represented with 3 types: Angelica TatianaeBordz, A.sachokiana, and Angelica Purpurascens [2].
Angelica L. gender is a rare kind of Azerbaijan flora. A.Tatianae is a noticeable perennial plant. A.Tatianae is a very valuable medicinal plant with 1-1,5m height and an empty stem. It passes to the blooming phase in July, the flowers are white. The length of the petals is about 1-2mm. The columns are short cone-shaped. The column is much longer than under columns and they are folded. The length of the umbrellas consists of various, roughly 25-35 rays. The petals are white and are gathered in the umbrella flower group. The sizes of the edge and middle flowers are different. The grown seeds are wide oval-shaped, backbones are narrow, from sides are large winged, above is naked. The length of the seed is 10 mm; the width is 5-6mm and consists of ribs. The seed has a specific dark smell.
The leaf limb is wide triangle-shaped, consists of 3 parts, it is featherlike, the length is about 30 cm, initial slices of a leaf are wide egg-shaped and the length is 20-25cm. The deep featherlike cut sharply pointed part is 6-8cm. The edges are unequal sharp cogged; the veinlet is short-hairy especially at the bottom part. Inside the stem is empty. It has a bitter taste. Coumarins are widely spread in types of Apiaceae, especially in the genus Angelica L.
Root parts of Angelica Tatianae type which were gathered from the west part of the Azerbaijan Gadabay region were cut, dried and substance mixture (17g) was used by extraction with (120g) alcohol 3 times. Three substances were extracted from chromatography of extracts from the root system of AngeliciaTatianae. The structures of matter are determined chemically and spectrally. The thin layer chromatography method was used to determine the individuality of the substances derived from the root of the plant, which has been identified as substances isopimpinellin, coumarin, xanthotoxin.
Feasibility of a Tablet-Based Program for Training Everyday Planning in Adolescents With Intellectual Disabilities
Authors: Palmqvist Lisa , Danielsson Henrik , Jönsson Arne , Rönnberg Jerker 
Published: October 2020

BackgroundIndividuals with intellectual disabilities (ID) show difficulties with everyday planning. A tablet-based training program for everyday planning may be a suitable intervention, but its feasibility must be evaluated. This study evaluated how behavior changes during training and if individuals with ID can use technology by themselves.MethodThirty-three adolescents with ID and 30 younger children with a typical development were recruited. The participants were instructed to train in school for a total of 300 minutes. After the intervention, the participants were matched on mental age (MA).ResultsOnly 16% of the participants trained for all 300 minutes. Participants in the MA group trained for a longer time than the ID group. Both groups made fewer errors per task at the end compared to the beginning. Individuals with ID started off making less attempts per task and increased their activity during the training. This pattern was not seen in the comparison group.ConclusionsBoth groups used the program independently, without adult supervision. However, a large group of participants in the ID group had a low usage time. Thus, the program might not have been feasible for that subgroup. The ID group increased their activity during the training which might mirror a strategy development of how to use the program. The change in behavior in activity on task attempts can be interpreted such that individuals with ID need a longer time to get familiarized with the technology. Tablet-based training programs are feasible for individuals with ID, but it is necessary to follow up on usage time.
Undifferentiated Pleomorphic Sarcoma Arising in a Fibrous Dysplasia Confirmed by GNAS Mutation Analysis
Authors: Okuda Miho , Kobayashi Satoshi , Gabata Toshifumi , Yamamoto Norio , Nojima Takayuki 
Published: October 2020

Case:
We report the case of a 78-year-old woman with undifferentiated pleomorphic sarcoma (UPS) of the proximal femur arising in a previous site of fibrous dysplasia (i.e., a liposclerosing myxofibrous tumor) that had been treated 4 years earlier with curetted surgery. GNAS mutation was detected in both the previous benign lesion and the UPS.

Conclusion:
Genetic analysis is useful in demonstrating the origin of the tumor especially in fibrous dysplasia with severe degeneration that have undergone malignant transformation.
HIV/AIDS-related Knowledge and Behavior among School-attending Afro-Descendant Youths in Ecuador
Authors: Hernandez Isabel , Sharma Vinita , Reina-Ortiz Miguel , Rosas Carlos , Ochoa Tatiana , Izurieta Ricardo , Teran Enrique 
Published: October 2020

Background or Objectives: HIV/AIDS transmission in Ecuador is considered a concentrated epidemic; therefore, there are some studies on high risk groups but there is limited published data regarding the HIV/AIDS risk factors among adolescents of African descent. In this study, we sought to explore the determinants of HIV/AIDS-related knowledge and behavior among afro-descendant youths attending schools in the city of Esmeraldas, Ecuador.
Methods: A cross-sectional survey among school-attending youths was conducted in Esmeraldas, Ecuador in 2010. Our target population was afro-descendant youths attending the last two years of high school. Thirty public high schools enrolling students in junior and senior years were identified. Outcome data were analyzed in the form of three composite variables. A multivariate linear regression model was built for each outcome.
Results: A total of 213 school-attending afro-descendant youths aged 14 to 21 years old were enrolled in this study. Gender distribution was almost equal with a 1:1.17 male to female ratio. Overall, students in this population scored well in comprehensive knowledge of HIV with 88% having medium or higher knowledge.
Conclusion and Global Health Implications: Knowledge of HIV and its determinants was medium to high, but knowledge of sexually transmitted diseases was low among afro-descendant Ecuadorian adolescents in our study. Results of this study might be instrumental in facilitating decision-making processes related to the planning, implementation, and evaluation of HIV/AIDS prevention and control strategies in this specific population.
Key words: • Afro-descendant • Adolescents • HIV/AIDS • Ecuador • Condom use • Risk factors• Epidemiology • Youths • Sexually transmitted infections • Transmission

Copyright © 2020 Hernandez et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)which permits unre-stricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Graduate Work-Readiness in Mauritius: A multi-stakeholder approach
Authors: Hardin-Ramanan Sarita , Gopee Shafiiq , Rowtho Vikash , Charoux Odylle 
Published: October 2020

Characterised by strong human capital dependency, Small Island Development States (SIDS) such as Mauritius depend largely on work-ready graduates to boost their economy. Yet, Graduate Work Readiness (GWR) and graduate unemployment feature prominently on the Mauritian government agenda. This paper investigates the previously unexplored issue of GWR in Mauritius through four key stakeholder lenses – those of the government, employers, universities, and undergraduates – before suggesting collaborative strategies to enhance graduate employability. The paper findings build on government and parastatal body interviews and qualitative survey responses from the Top 100 companies, higher education institution directors and final year undergraduates in Mauritius. Study results and recommendations are derived from a thematic content analysis of interview transcripts and qualitative survey data. Results indicate that there is a strong need to (1) strengthen stakeholder links, (2) enforce industry-centric university curricula, (4) improve graduate work experience, (4) hone graduate soft skills, and (5) their attitude to work. A Graduate Work Readiness Integrated Stakeholder Framework (GWRISF) supported by a National Work Integrated Learning Committee (NWILC) is then recommended. It is envisaged that proposed strategies will not only assist Mauritian stakeholders in better joining forces for GWR improvement but can also be useful to other comparable SIDS.
The effects of exergaming on pain, postural control, technology acceptance and flow experience in older people with chronic musculoskeletal pain: a randomised controlled trial
Authors: Ditchburn Jae-Llane , Schaik Paul van , Dixon John , MacSween Alasdair , Martin Denis 
Published: October 2020

Abstract
Background: Older people with chronic musculoskeletal pain are at risk of falls. This study aimed to investigate the effects of exergaming on pain and postural control in older people with chronic musculoskeletal pain. Secondary outcomes were technology acceptance, flow experience, perceived physical exertion, expended mental effort and heart rate. Methods: 54 older adults (age: 71 ± 5 years) with chronic musculoskeletal pain were randomised into 2 groups. Group 1 received exergaming training using the Interactive Rehabilitation and Exercise System (IREX®). Group 2 undertook traditional gym-based exercise (TGB). Both groups completed twice weekly 40-minute exercise sessions for six weeks. Perceived pain was measured using a numeric pain rating scale and the Multidimensional Affect and Pain Survey questionnaire. Postural control was measured as sway using a Kistler™ force platform. Technology acceptance was measured with the Unified Theory of Acceptance and Use of Technology questionnaire and flow experience with the Flow State Scale. Physiological measures of perceived physical exertion, expended mental effort and heart rate were recorded during all sessions. Results: The exergaming group demonstrated significant reductions in pain intensity and thermal pain including a near significant approach in physical engagement in comparison to TGB group. Although no intervention effects on postural control were found, the exergaming group showed significant improvements in three sway measures (AP SD, ML SD and AP range) over time whereas significant improvements in ML range were found in the TGB group. Relating to technology acceptance, significant intervention effects on social influence and behavioural intention were found in the TGB group instead, although both groups demonstrated increases of acceptance over time. Regarding flow experience, concentration at task was significantly influenced in the TGB group and significant increases in flow variables over time were observed in both groups. Significant increases over time in perceived physical exertion and expended mental effort were found in both groups. Conclusion: Our findings support the potential of exergaming to alleviate pain and improve balance in older people with chronic musculoskeletal pain. Both forms of exercise are acceptable, intrinsically motivating and show evidence of benefit to older people with chronic musculoskeletal pain. Trial registration: ClinicalTrials.gov Identifier: NCT04029285 (retrospectively registered, July 23, 2019) https://clinicaltrials.gov/ct2/show/study/NCT04029285?term=Alasdair+Macsween&draw=2&rank=2
Endothelial Dysfunction and Platelet Hyperaggregation in type 2 Diabetes Mellitus: The era of novel anti-diabetic agents
Authors: Daios Stylianos , Kaiafa Georgia , Pilalas Dimitrios , Nakou Ifigeneia , Kanellos Ilias , Kirdas Konstantinos , Despoudi Kalliopi , Papanas Nikolaos , Savopoulos Christos 
Published: October 2020

Background:
Diabetes mellitus (DM) incidence is ever-increasing and along with its microvascular and macrovascular complications is associated with a high morbidity and mortality burden globally. Major components of diabetes
pathophysiology include glucotoxicity, lipotoxicity and insulin resistance, disturbing the vascular wall integrity and leading
to endothelial dysfunction and platelet hyperaggregation.

Objective:
This review aims to identify and summarize the effect of novel anti-diabetic agents (glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, sodium-glucose co-transporter -2 inhibitors) on endothelial (EF) and platelet function (PF) and evaluate the consistency with the results of cardiovascular outcomes studies.

Methods:
We performed a structured search of the PubMed database for peer-reviewed research of the literature between
1981 and 2020 regarding the effect of DM and novel anti-diabetic agents on EF and PF.

Results:
We analyzed data regarding the effect of novel anti-diabetic agents on EF and PF as well as the pathophysiological
interplay between DM, PF, and EF. The available studies use different methods to evaluate these outcomes and the results of
different studies are rather conflicting as a result of different study designs, combinations of drugs tested, small study samples and patient population heterogeneity.

Conclusion:
The currently available data do not unequivocally support a consistent effect of novel antidiabetic agents on EF
and PF. Further study is required ideally with validation of the results with clinical outcomes.
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan
Authors: Uraoka Mirai , Shimizu Makiko , Kuwajima Yoshiki , Mizugaki Ami , Yokoyama Haruka , Mure Kanae , Yamazaki Hiroshi 
Published: October 2020

Background:
The relationships between lifestyle-related diseases and polymorphic drug-metabolizing
enzyme activities in the general population in Japan remain unclear.

Objective:
In this study, the relationships between an index of arteriosclerosis and the phenotypic activities of
flavin-containing monooxygenase 3 (FMO3) and cytochrome P450 (P450) 2A6 were analysed.

Methods:
Subjects in a general population in Japan (age range 35-97 years, 640 men and 795 women, 12%
were current smokers) who took part in a health check program were recruited.

Results:
Subjects were divided into two groups using the median ankle-brachial pressure index (ABI) score.
Subjects harbouring P450 2A6 wild-type allele had a significant age-adjusted odds ratio of 1.3 (95% CI,
1.0-1.6) of having a lower than median ABI score compared with subjects for mutant P450 2A6. For subjects
with wild-type FMO3, the odds ratio of 0.89 was not significant. The proportions of P450 2A6 extensive metabolizers
varied significantly across the inter-quartile ranges of the ABI scores (p = 0.008). Furthermore, the proportion
of subjects with low ABI scores was also dependent on the phenotypic P450 2A6 activity (p = 0.025) as
estimated from the P450 2A6 genotype. These results suggest that in a general population in Japan, the ABI
score, as a risk index for arteriosclerosis, is associated with the predicted P450 2A6 phenotype but is not associated
with FMO3 function.

Conclusion :
The P450 2A6 wild-type allele may be a possible candidate biomarker for arteriosclerosis in a general
population in Japan with a variety of dietary habits.
Paeoniflorin Affects Hepatocellular Carcinoma Progression by Inhibiting Wnt/β-Catenin Pathway through Downregulation of 5-HT1D
Authors: Zhou Yang , Liu Xun , Gao Yahan , Tan Rulan , Wu Zhiyuan , Zhong Qixin , Zeng Feng 
Published: October 2020

Background:Hepatocellular Carcinoma (HCC) is a primary liver cancer with high mortality. Paeoniflorin is a pinane monoterpene picroside with anti-tumor effect isolated from Chinese peony root and white peony root.Objective:The study was conducted to investigate the underlying mechanism of Paeoniflorin (PF) regulating Hepatocellular Carcinoma (HCC) progression via 5-hydroxytryptamine receptor 1D (5-HT1D).Methods:HepG2 and SMMC-7721 hepatoma cells were treated with different concentrations of PF (0, 5, 10, 20 μM). Cell proliferation, apoptosis, migration, and invasion were examined by CCK-8 and colony formation assays, flow cytometry, wound healing assay, and transwell assay, respectively. RTqPCR assay was used to detect the expression level of 5-HT1D, and Western blot assay was used to detect the expressions of 5-HT1D and Wnt/β-catenin pathway-related proteins.Results:With the increase in PF concentration, the mRNA levels of 5-HT1D in HepG2 and SMMC- 7721 hepatoma cells were decreased in a dose-dependent manner, and the proliferation, colony formation, migration and invasion ability of cells were gradually weakened, while the apoptosis rate was gradually increased. Overexpression of 5-HT1D significantly promoted the proliferation, colony formation, migration and invasion of HepG2 and SMMC-7721 cells, and increased the expression of Wnt/β-catenin pathway-related proteins, β -actenin, survivin, C-myc, and Cyclin D1. Furthermore, 5-HT1D overexpression could reverse the effect of PF on hepatoma cells and inhibit the expressions of Wnt/β-catenin pathway-related proteins.Conclusion:PF may inhibit the progression of HCC by blocking Wnt/β-catenin pathway expression through downregulating 5-HT1D.
Seventeen-Year Medical Professional Liability Experience in a Level III University Hospital
Authors: Bolcato Matteo , Fassina Giacomo , Sanavio Matteo , Aprile Anna 
Published: October 2020

Introduction:
In recent decades, the number of medical professional liability disputes has
grown exponentially, becoming a well-studied aspect of public healthcare. Legal medicine is an essential
tool in managing this phenomenon.

Methods:
This article reports the results of the analysis of disputes for medical professional liability
in a Level III University Hospital in Italy. The study covers the time period from 01.01.2003 to
31.12.2019.

Results:
About 33% of claims have been compensated. Those claims fall within the following categories:
37% in the surgical field, 17% in the field of internal medicine, and 35% in the emergency care
field. As for the types of a medical mistake, compensation was awarded in 30% of diagnostic error
cases, 26% of therapeutic error cases, 47% of execution error cases, and 55% of organizational deficiency
cases.

Discussion:
The difference in the rate of compensation between the various medical fields or types of
error depends on specific medico-legal characteristics. The aim of advanced healthcare systems is to
prevent medical liability disputes by analyzing this phenomenon and improving clinical risk management
programs. In particular, according to our study, events related to organizational deficiencies are
the most preventable. In addition, through the use of a dedicated reporting procedure, medico-legal
analysis of malpractice cases may be the key to risk reduction.

Conclusion:
Every major hospital should set up a medico-legal watchdog responsible for collecting
and analyzing information on professional medical liability disputes in order to prevent and manage
such events.
1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities
Authors: Ojha Madhwi , Yadav Divya , Kumar Avinash , Dasgupta Suman , Yadav Rakesh 
Published: October 2020

:
1, 8- Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic compounds
which has garnered the interest of researchers due to its versatile biological activities. It is
known to be used as an antimicrobial, anti-psychotic, anti-depressant, anti-convulsant, anti-
Alzheimer’s, anti-cancer, analgesic, anti-inflammatory, antioxidant, anti-viral, anti-hypertensive, antimalarial,
pesticides, anti-platelets, and CB2 receptor agonist, etc. The present review highlights the
framework of biological properties of synthesized 1, 8-naphthyridine derivatives developed by various
research groups across the globe.
Overexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance in Breast Cancer Patients
Authors: Karamat Uzma , Ejaz Samina 
Published: October 2020

Background:
The prevalence of breast cancer is increasing at an alarming rate and thus
demands exploration of the most relevant diagnostic biomarkers. RAD50 is a cancer susceptibility
gene that encodes a DNA damage repairing protein. Its role in breast cancer as clinico-pathological
specific biomarker has yet to be explored.

Objective:
This study was aimed to investigate the RAD50 expression and its promoter’s methylation
level variations in breast invasive carcinoma patients having different clinico-pathological features.
This study further explored the mutational spectrum of RAD50 and the correlation of its expression
with the survival of patients and the effectiveness of drugs used for treatment.

Methods:
Enrichment analysis of RAD50 was accomplished using the platform of GeneCards. The
information regarding RAD50 expression, its promoter methylation and impact on survival of patient
was retrieved from TCGA and CPTAC databases. However, the effect of RAD50 expression
on tumor’s response to various drugs was deduced through the analysis of CCLE and genomic of
GDSC dataset.

Results:
The promoter hyper-methylation and elevated expression of RAD50 was documented in
various subgroups of breast invasive carcinoma. The subjects having low/medium expression levels
were observed to survive longer than patients exhibiting high expression of RAD50 except for
post-menopausal subjects. The frequency of missense mutations was higher in RAD50 than truncating
mutations. Most of the drugs were found to have a positive correlation with RAD50 expression.

Conclusion:
The status of RAD50 promoter’s methylation inversely correlates with the expression
level of RAD50. While RAD50 is overexpressed in breast cancer patients and thus makes tumor resistant
against many anti-cancer drugs.