bluuebunny/crossref_metadata_2025_split huggingface dataset:
Needs for a gender‐based perimarital couples’ counselling services in Iran
Authors: Simbar Masoumeh , Rahmanian Fatemeh , Nazarpour Soheila , Ramezankhani Ali , Zayeri Farid 
Published: November 2020

AbstractAimTo assess needs for a gender‐sensitive perimarital counselling services in Iran.DesignA descriptive cross‐sectional study.MethodsThis was a study on all 236 premarital counselling providers in 37 health centres in Shiraz‐Iran. The tools for data collection included the following: (a) a demographic information questionnaire and; (b) a valid and reliable Needs Assessment questionnaire for Gender‐Sensitive Perimarital Counseling Services (GSPCS) in 3 sections of needs for process, structure and policy making of the perimarital counselling services. Data were analysed using SPSS 21.ResultsAll health providers with average working experience of 8.63 (SD 5.35) years participated in the study. Results demonstrated highest scores for needs related to facilities as the structure of the services (90.09 SD 13.70 per cent) and community empowerment (89.50 SD 16.67 per cent) as the necessary policy for the gender‐sensitive services. We concluded that providing gender‐sensitive perimarital counselling healthcare services needs to reform the process, structure and policies of the services.
Beliefs, fear and awareness of women about breast cancer: Effects on mammography screening practices
Authors: Emami Lida , Ghahramanian Akram , Rahmani Azad , Mirza Aghazadeh Ahmad , Onyeka Tonia C. , Nabighadim Amirreza 
Published: November 2020

AbstractAimThis study sought to investigate the beliefs, fear and awareness about breast cancer and mammography screening practices of women in Iran.MethodsThis descriptive‐correlational study was conducted at Tabriz, East Azerbaijan Province, northwest of Iran from February–July 2017. One hundred and fifty‐two women aged 40 years and older, who were referred to 12 health centres for health services were selected via clustering sampling. Associations between variables and mammography screening practices were examined using bivariate and multivariate logistic regression analyses. Participants who had a mammogram within the last 24 months were compared with those who had none. Sociodemographic questionnaire, Champion's Breast Cancer Fear Scale, Champion's Health Belief Model Scale for Mammography Screening, Breast Cancer Awareness Scale and Powe Fatalism Inventory were the tools used for data gathering.ResultsJust 38.2% of women reported having a mammogram within the last 24 months. Self‐efficacy (OR = 5.36, B = 1.68, p < .001), susceptibility (OR = 2.83, B = 1.04, p < .001), motivation (OR = 2.11, B = 0.75, p = .024) and lower perceived barriers (OR = 0.25, B = −1.37, p < .001) were associated with being screened. Neither fatalistic belief nor awareness towards breast cancer was significant.
Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design
Authors: Ross Jeffrey S. , Sokol Ethan S. , Moch Holger , Mileshkin Linda , Baciarello Giulia , Losa Ferran , Beringer Andreas , Thomas Marlene , Elvin Julia A. , Ngo Nhu , Jin Dexter X. , Krämer Alwin 
Published: November 2020

Abstract

Background
Carcinoma of unknown primary origin (CUP) accounts for 2%–5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or immunotherapy treatment arms based on genomic profiling. We performed a retrospective analysis of CUP cases referred for CGP to determine how many were potentially eligible for enrollment into an experimental CUPISCO arm.

Materials and Methods
Centrally reviewed adenocarcinoma and undifferentiated CUP specimens in the FoundationCore database were analyzed using the hybrid capture-based FoundationOne CDx assay (mean coverage, &gt;600×). Presence of genomic alterations, microsatellite instability (MSI), tumor mutational burden (TMB), genomic loss of heterozygosity (gLOH), and programmed death-ligand 1 (PD-L1) positivity were determined.

Results
A total of 96 of 303 patients (31.7%) could be matched to an experimental CUPISCO arm. Key genomic alterations included ERBB2 (7.3%), PIK3CA (6.3%), NF1 (5.6%), NF2 (4.6%), BRAF (4.3%), IDH1 (3.3%), PTEN, FGFR2, EGFR (3.6% each), MET (4.3%), CDK6 (3.0%), FBXW7, CDK4 (2.3% each), IDH2, RET, ROS1, NTRK (1.0% each), and ALK (0.7%). Median TMB was 3.75 mutations per megabase of DNA; 34 patients (11.6%) had a TMB ≥16 mutations per megabase. Three patients (1%) had high MSI, and 42 (14%) displayed high PD-L1 expression (tumor proportion score ≥50%). gLOH could be assessed in 199 of 303 specimens; 19.6% had a score of &gt;16%.

Conclusions
Thirty-two percent of patients would have been eligible for targeted therapy in CUPISCO. Future studies, including additional biomarkers such as PD-L1 positivity and gLOH, may identify a greater proportion potentially benefiting from CGP-informed treatment. Clinical trial identification number. NCT03498521

Implications for Practice
The findings of this retrospective analysis of carcinoma of unknown primary origin (CUP) cases validate the experimental treatment arms being used in the CUPISCO study (NCT03498521), an ongoing randomized trial using comprehensive genomic profiling to assign patients with CUP to targeted or immunotherapy treatment arms based on the presence of pathogenic genomic alterations. The findings also suggest that future studies including additional biomarkers and treatment arms, such as programmed death-ligand 1 positivity and genomic loss of heterozygosity, may identify a greater proportion of patients with CUP potentially benefiting from comprehensive genomic profiling-informed treatment.
Optimizing pharmacologic thromboprophylaxis use in pediatric orthopedic surgical patients through implementation of a perioperative venous thromboembolism risk screening tool
Authors: MacNevin Wyatt , Padhye Kedar , Alkhalife Yasser , Price Victoria , El‐Hawary Ron , Branchford Brian R. , Stevens Sarah , Kulkarni Ketan 
Published: November 2020

AbstractBackgroundAlthough rare, venous thromboembolic events (VTE) are a significant challenge in pediatric orthopedic surgical patients (POSP). A VTE thromboprophylaxis screening tool was developed and implemented in POSPs at the IWK Health Centre since October 2016.ObjectivesThis retrospective cohort study was designed to evaluate and assess the impact of the VTE thromboprophylaxis screening tool in terms of use of thromboprophylaxis in POSP.MethodsUsing the tool, POSPs were screened and were categorized into risk groups. Patient groups were compared and spearman correlation analysis was performed to show the strength of association between risk factors and thromboprophylaxis. Retrospective screening of pre‐algorithm patients who received thromboprophylaxis was done to further assess the screening tool.ResultsAfter the implementation of the VTE thromboprophylaxis screening tool in POSPs, there was a 47.9% reduction in the use of thromboprophylaxis (P = 0.046) as compared with before. Neither VTE nor significant bleeding complications occurred before or after screening tool implementation. Compliance with the screening tool was excellent (100% of patients in the high‐risk category received thromboprophylaxis). High‐risk patients were more likely to have body mass index > 30 (35.7%), limited/altered mobility (57.1%), and to be undergoing a complicated/repeat surgery (64.3%).ConclusionsThe present study demonstrates successful implementation of a VTE thromboprophylaxis screening tool that resulted in significant reduction in use of thromboprophylaxis in POSPs with no increase in VTE or change in bleeding complications.
Perinatal outcome and prognostic factors of fetal megacystis diagnosed at 11–14 week's gestation
Authors: Kao Cindy , Lauzon Julie , Brundler Marie‐Anne , Tang Selphee , Somerset David 
Published: November 2020

AbstractObjectivesTo evaluate aneuploidy rate, prognostic factors, and perinatal outcomes following a diagnosis of fetal megacystis at 11–14 week's gestation.MethodsA retrospective study of first trimester fetal megacystis from 2010 to 2020 was performed, including ultrasound finding, perinatal outcomes, pathology reports, genetic tests, and neonatal investigations.ResultsA total of 98 cases of first trimester fetal megacystis was identified with an overall aneuploidy rate of 12%. There were 54% live births and 46% fetal losses including spontaneous fetal demise and elective termination. Among the 45 fetal losses, 64% had additional structural abnormalities at index ultrasound and final diagnoses were achievable in 64% cases. Among the 53 livebirths, additional ultrasound abnormalities were detected in only 1 fetus and spontaneous resolution of megacystis was detected in 96% of cases. The two cases where fetal megacystis persisted had major postnatal diagnoses: cloacal malformation and megacystis‐microcolon‐intestinal hypoperistalsis syndrome, respectively. Our data showed LBD ≥ 12 mm was the best individual predictor of adverse perinatal outcome and all 11 cases of lower urinary tract obstruction (LUTO) were diagnosed in fetuses with LBD ≥ 12 mm.ConclusionsFirst trimester ultrasound provides important prognostic factors and isolated megacystis <12 mm is associated with a positive outcome.
Fetal dural sinus thrombosis: A systematic review
Authors: Sacco Adalina , Pannu Deepika , Ushakov Fred , Dyet Leigh , Pandya Pranav 
Published: November 2020

AbstractIntroductionFetal dural sinus thrombosis (DST) is a rare condition. Although numerous case reports exist, the findings appear heterogenous and providing accurate patient counselling remains challenging.MethodsA systematic literature review was conducted in accordance with PRISMA guidance.ResultsThirty‐one studies including 78 patients were included in this review. No association with maternal or neonatal coagulopathy, infection or trauma was found. The average gestational age at diagnosis was 25 weeks (range 17–34 weeks). Approximately half of foetuses affected were female (48.7%); one quarter were male (25.6%) and one quarter had no sex stated (25.6%). Termination of pregnancy was chosen in 25.6% of cases (20/78). In continuing pregnancies,10.3% (6/58) experienced a perinatal death. Antenatally, the majority of lesions either decreased in size (38.5%) or completely resolved (32.7%). The neonatal or childhood outcome was normal in 88.0% of survivors (44/50). The average age at follow up was 16.4 months, ranging from birth to 6 years.ConclusionThis review found that 10% of DST cases experience in‐utero or neonatal death. In survivors, the majority of cases reduce in size or completely resolve in pregnancy and 85% are reported to have a good outcome. However, further evidence is needed regarding long‐term neurocognitive sequelae.
Using artificial intelligence to identify anti‐hypertensives as possible disease modifying agents in Parkinson's disease
Authors: Visanji Naomi P. , Madan Piyush , Lacoste Alix M. B. , Buleje Italo , Han Yanyan , Spangler Scott , Kalia Lorraine V. , Hensley Alford Sharon , Marras Connie 
Published: November 2020

AbstractPurposeDrug repurposing is an effective means of increasing treatment options for diseases, however identifying candidate molecules for the indication of interest from the thousands of approved drugs is challenging. We have performed a computational analysis of published literature to rank existing drugs according to predicted ability to reduce alpha synuclein (aSyn) oligomerization and analyzed real‐world data to investigate the association between exposure to highly ranked drugs and PD.MethodsUsing IBM Watson for Drug Discoveryâ (WDD) we identified several antihypertensive drugs that may reduce aSyn oligomerization. Using IBM MarketScanâ Research Databases we constructed a cohort of individuals with incident hypertension. We conducted univariate and multivariate Cox proportional hazard analyses (HR) with exposure as a time‐dependent covariate. Diuretics were used as the referent group. Age at hypertension diagnosis, sex, and several comorbidities were included in multivariate analyses.ResultsMultivariate results revealed inverse associations for time to PD diagnosis with exposure to the combination of the combination of angiotensin receptor II blockers (ARBs) and dihydropyridine calcium channel blockers (DHP‐CCB) (HR = 0.55,p < 0.01) and angiotensin converting enzyme inhibitors (ACEi) and diuretics (HR = 0.60,p‐value <0.01). Increased risk was observed with exposure to alpha‐blockers alone (HR = 1.81,p < 0.001) and the combination of alpha‐blockers and CCB (HR = 3.17,p < 0.05).ConclusionsWe present evidence that a computational approach can efficiently identify leads for disease‐modifying drugs. We have identified the combination of ARBs and DHP‐CCBs as of particular interest in PD.
Sustainable phenolic thermosets coatings derived from urushiol
Authors: Xia Jianrong , Xue Hanyu , Gao Renjin , Zhang Yuchi , Lin Qi 
Published: November 2020

AbstractThe over‐exploitation of finite fossil resources and/or the increased environmental and sustainable awareness inspire scientists and technologists to search for inexpensive alternatives from renewable chemicals. Phenol formaldehyde (PF) resins, the oldest type of synthetic polymers with good mechanical properties and heat resistance, are widely used in the production of coatings, laminates, molding compositions, and glues. Here, biobased urushiol‐derived PF resins were synthesized from the alkali‐catalyzed reaction between urushiol and formaldehyde. The chemical compositions and molecular structures of resole resins were characterized by carbon‐13 nuclear magnetic resonance and Fourier transform infrared spectroscopy, and their curing behaviors were studied by differential scanning calorimetry. The as‐prepared urushiol‐derived resole resins had methylol (Ph−CH2OH), ortho‐ and para‐hemiformal groups (Ph−CH2OCH2OH), and the para−para/ortho−para/ortho−ortho links of methylene groups (Ph−CH2−Ph), whereas the resole resins had low curing temperatures at about 100–113°C. Additionally, given the long side alkyl group moiety on the aromatic rings of urushiol, the films of cured urushiol‐derived resole resins had low glass transition temperatures of 132 ± 2°C. Furthermore, the as‐prepared urushiol‐derived coatings exhibited excellent physical and mechanical properties.
Is the twig bent as the tree is inclined? Children and parents interacting with school‐distributed literacy assignments
Authors: Akkermans‐Rutgers Marlot , Doornenbal Jeannette , Kassenberg Annelies , Bosker Roel , Doolaard Simone 
Published: November 2020

AbstractIn this study, we analyze in‐depth interviews conducted with 26 Dutch third‐graders as well as interviews with one of each child's parents. The children attended one of six schools, each with a relatively large population of families with a low socioeconomic status, where home‐based literacy assignments aimed at increasing children's enjoyment of reading were distributed for a duration of 3 years. The aim of this study is to gain knowledge of distinctive interaction characteristics of child‐parent dyads regarding at‐home literacy, to learn how these characteristics can help educational professionals and researchers answer to the needs of children and parents when designing and distributing at‐home reading assignments. Based on the attitudes towards reading and the skillset of child and parent(s), we distinguished three reader‐profiles: (1) Autonomously motivated readers, (2) Incompatible readers, and (3) Generational non‐readers. The practical implications of our research are that, to be appealing, at‐home reading assignments should be differentiated, nonrepetitive, and concrete, complete, and structured. Prerequisite implications are that both children and parents value regular positive feedback on their at‐home literacy activities and that, in approaching parents, it appears to be advisable to take them for what they are: parents, not substitute teachers.
Profile analysis of the Personality Assessment Inventory‐Adolescent (PAI‐A) for individuals with autism spectrum disorder
Authors: Hooks Elizabeth , Dale Brittany A. , Hernandez Finch Maria E. 
Published: November 2020

AbstractThe purpose of the present study was to determine if individuals with autism spectrum disorder (ASD) display a unique pattern of responses on the Personality Assessment Inventory‐Adolescent (PAI‐A). Twenty adolescents between ages 12 and 18 completed the PAI‐A, and their scores were compared to matched community and clinical samples from the standardization sample of the PAI‐A. Results of a profile analysis indicated the ASD group displayed unique scale elevations, which may help clarify the interpretive quality of the PAI‐A with individuals with autism. Clinicians and school psychologists should be aware of this research when selecting tools to evaluate adolescents with ASD.
A DFT study on the mechanism of the formation of 1,4,2,3‐dithiadiazinanes by head‐to‐head [3 + 3] cyclodimerization of thiocarbonylS‐imides
Authors: Buddensiek Dirk , Mlostoń Grzegorz , Matczak Piotr , Voss Jürgen 
Published: November 2020

AbstractThe possible minimum energy paths (MEP) for the [3 + 3] cyclodimerization (33CD) of thiophosgeneS‐imides under formation of tetrachlorodithiadiazinanes are determined with density functional theory (DFT) calculations. Application of the natural bond orbital (NBO) method in combination with electron localization function (ELF) analysis corroborates the experimental observation of the unexpected head‐to‐head 33CD of thiophosgeneS‐(N‐arylimides) to form the corresponding 2,3‐diaryl‐5,5,6,6‐tetrachloro‐1,4,2,3‐dithiadiazinanes instead of the isomeric 2,5‐diaryl‐3,3,6,6‐tetrachloro‐1,4,2,5‐dithiadiazinanes. Based on complete active space self‐consistent field (CASSCF) results, delocalized diradicals are postulated as intermediates for the stepwise pseudoradical type formation of the obtained 2,3‐diaryl‐5,5,6,6‐tetrachloro‐1,4,2,3‐dithiadiazinanes, whereby non‐covalent interactions play an important role.
Effect of network connectivity on the mechanical and transport properties of block copolymer gels
Authors: Rankin Lucas A. , Lee Byeongdu , Mineart Kenneth P. 
Published: November 2020

AbstractEstablishing the independent tunability of transport and mechanical properties in polymer gels would significantly contribute to their implementation as transdermal drug delivery media, among other things. The work conducted herein uses facile changes in the formulation of physically crosslinked styrenic ABA/AB block copolymer organogels to alter their mechanical properties independently from the mass transport of an internally‐loaded nanocarrier. Such independent tunability is made possible by altering the relative amounts of ABA triblock and AB diblock copolymers while holding total copolymer concentration fixed. Specifically, three series of gels each with a fixed total copolymer concentration (10, 20, or 30 wt%) comprised of varying triblock copolymer concentration are studied. Small angle x‐ray scattering confirms that, at the nanoscale, only gel network connectivity changes within each series, while mechanical and release experiments show that increasing network connectivity leads to significant growth of gel moduli, but little change in nanocarrier release rate.
The unmet needs of childhood cancer survivors in long‐term follow‐up care: A qualitative study
Authors: Hendriks Manya Jerina , Harju Erika , Michel Gisela 
Published: November 2020

AbstractObjectiveEvidence suggests benefits of long‐term follow‐up care attendance for childhood cancer survivors, but studies show poor inclusion of survivorship issues and needs. While information needs of childhood cancer survivors have been addressed previously, few studies specifically investigated the supportive care needs of survivors beyond the domain of information and communication. Therefore, this qualitative study aimed to assess the unmet needs of childhood cancer survivors with regards to their long‐term survivorship.MethodsChildhood Cancer Switzerland invited survivors of childhood cancer to participate in our study. We used semistructured interviews to assess survivors' experiences regarding the impact of their disease and the (un)met needs during their survivorship. Data analysis followed the principles of qualitative content analysis.ResultsInterviews were conducted with 28 childhood cancer survivors (mean age 31 years, age at diagnosis 9 years, time since end of treatment 19 years). Key themes in relation to unmet needs of survivors were (1) lacking psychosocial support, (2) lacking collaboration and decentralization of care, (3) starting from zero, and (4) need for centralized, specialized, and individualized services.ConclusionsOur findings revealed a demand for integrating psychosocial support in long‐term follow‐up care and a strong need for personalized, centralized, and interdisciplinary long‐term follow‐up care. Current established interdisciplinary clinics should be further extended to provide centralized, personalized, and evidence‐based long‐term follow‐up care including adequate psychosocial support for all childhood cancer survivors.
Major depressive disorders in outpatients with cancers at the Nigerian National Hospital
Authors: Aruah Simeon Chinedu , Eze Christian Nweke 
Published: November 2020

AbstractObjectiveFrequently, little attention is paid by clinicians on the psychiatric disorders that may be associated with cancers. The aim of this study was to determine the prevalence of major depressive disorders in outpatients with cancers at the Radiology Oncology Centre of the National Hospital, Abuja, Nigeria. It also sought to determine the socio‐demographic and clinical factors associated with the disorder.MethodA sample of 177 randomly selected outpatients with cancers was interviewed with socio‐demographic questionnaire and the major depressive episode section of the Mini International NeuroPsychiatric Interview at the hospital.ResultsThe mean age (SD) of the participants was 48.9 (13.8) years, with females accounting for 61.6% of them. The prevalence of current major depressive disorder, past depressive episode and recurrent depressive disorder were 25.1%, 24.3% and 7.5%, respectively. The current depressive disorder was found to be significantly associated with the presence of disturbing pain and the stage of the disease.ConclusionThe occurrence of depressive disorders in patients with cancers at the hospital was high. Their assessment and treatment should be prioritized to ensure complete management of the patients with cancer conditions.