bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-related differences in wall remodeling and intraluminal thrombus resolution in a rat saccular aneurysm model
Authors: Morel Sandrine , Karol Agnieszka , Graf Vanessa , Pelli Graziano , Richter Henning , Sutter Esther , Braunersreuther Vincent , Frösen Juhana , Bijlenga Philippe , Kwak Brenda R. , Nuss Katja M. 
Published: December 2019

OBJECTIVEIntracranial aneurysms (IAs) are more often diagnosed in women. Hormones and vessel geometry, which influences wall shear stress, may affect pathophysiological processes of the arterial wall. Here, the authors investigated sex-related differences in the remodeling of the aneurysm wall and in intraluminal thrombus resolution.METHODSA well-characterized surgical side-wall aneurysm model was used in female, male, and ovariectomized rats. Decellularized grafts were used to model highly degenerated and decellularized IA walls and native grafts to model healthy IA walls. Aneurysm growth and thrombus composition were analyzed at 1, 7, 14, and 28 days. Sex-related differences in vessel wall remodeling were compared with human IA dome samples of men and pre- and postmenopausal women.RESULTSAt 28 days, more aneurysm growth was observed in ovariectomized rats than in males or non-ovariectomized female rats. The parent artery size was larger in male rats than in female or ovariectomized rats, as expected. Wall inflammation increased over time in all groups and was most severe in the decellularized female and ovariectomized groups at 28 days compared with the male group. Likewise, in these groups the most elastin fragmentation was seen at 28 days. In female rats, on days 1, 7, and 14, the intraluminal thrombus was mainly composed of red blood cells and fibrin. On days 14 and 28, macrophage and smooth muscle cell invasion inside the thrombus was shown, leading to the removal of red blood cells and deposition of collagen and elastin. On days 14 and 28, similar profiles of thrombus reorganization were observed in male and ovariectomized female rats. However, collagen content in thrombi and vessel wall macrophage content were higher in aneurysms of male rats at 28 days than in those of female rats. On day 28, thrombus coverage by endothelial cells was lower in ovariectomized than in female or male rats. Finally, analysis of human IA domes showed that endothelial cell coverage was lower in men and postmenopausal women than in younger women.CONCLUSIONSAneurysm growth and intraluminal thrombus resolution show sex-dependent differences. While certain processes (endothelial cell coverage and collagen deposition) point to a strong hormonal dependence, others (wall inflammation and aneurysm growth) seem to be influenced by both hormones and parent artery size.
In-depth characterization of a long-term, resuscitated model of acute subdural hematoma–induced brain injury
Authors: Datzmann Thomas , Kapapa Thomas , Scheuerle Angelika , McCook Oscar , Merz Tamara , Unmuth Sarah , Hoffmann Andrea , Mathieu René , Mayer Simon , Mauer Uwe Max , Röhrer Stefan , Yilmazer-Hanke Deniz , Möller Peter , Nussbaum Benedikt Lukas , Calzia Enrico , Gröger Michael , Hartmann Clair , Radermacher Peter , Wepler Martin 
Published: December 2019

OBJECTIVEAcute subdural hematoma (ASDH) is a leading entity in brain injury. Rodent models mostly lack standard intensive care, while large animal models frequently are only short term. Therefore, the authors developed a long-term, resuscitated porcine model of ASDH-induced brain injury and report their findings.METHODSAnesthetized, mechanically ventilated, and instrumented pigs with human-like coagulation underwent subdural injection of 20 mL of autologous blood and subsequent observation for 54 hours. Continuous bilateral multimodal brain monitoring (intracranial pressure [ICP], cerebral perfusion pressure [CPP], partial pressure of oxygen in brain tissue [PbtO2], and brain temperature) was combined with intermittent neurological assessment (veterinary modified Glasgow Coma Scale [MGCS]), microdialysis, and measurement of plasma protein S100β, GFAP, neuron-specific enolase [NSE], nitrite+nitrate, and isoprostanes. Fluid resuscitation and continuous intravenous norepinephrine were targeted to maintain CPP at pre-ASDH levels. Immediately postmortem, the brains were taken for macroscopic and histological evaluation, immunohistochemical analysis for nitrotyrosine formation, albumin extravasation, NADPH oxidase 2 (NOX2) and GFAP expression, and quantification of tissue mitochondrial respiration.RESULTSNine of 11 pigs survived the complete observation period. While ICP significantly increased after ASDH induction, CPP, PbtO2, and the MGCS score remained unaffected. Blood S100β levels significantly fell over time, whereas GFAP, NSE, nitrite+nitrate, and isoprostane concentrations were unaltered. Immunohistochemistry showed nitrotyrosine formation, albumin extravasation, NOX2 expression, fibrillary astrogliosis, and microglial activation.CONCLUSIONSThe authors describe a clinically relevant, long-term, resuscitated porcine model of ASDH-induced brain injury. Despite the morphological injury, maintaining CPP and PbtO2 prevented serious neurological dysfunction. This model is suitable for studying therapeutic interventions during hemorrhage-induced acute brain injury with standard brain-targeted intensive care.
PENGARUH MODAL KERJA TERHADAP RETURN ON ASSET (ROA) MELALUI PENJUALAN
Authors: Abidin Zaenal , Setiadi Daryono 
Published: December 2019

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh modal kerja terhadap penjualan, penjualan terhadap Return On Asset (ROA) pada PD. Sri Tanjung Indramayu.
Metode yang digunakan pada penelitian ini adalah metode deskriptif asosiatif dengan pendekatan kuantitatif. Dikatakan pendekatan kuantitatif sebab pendekatan yang digunakan di dalam usulan penelitian, proses hipotesis, analisa data dan kesimpulan data sampai dengan penulisannya menggunakan aspek pengukuran, perhitungan, rumus dan kepastian data numerik, untuk teknik analisis data yang dipakai diantaranya analisis korelasi, analisis koefisien determinasi, dan uji hipotesis (uji t).
Berdasarkan hasil analisis yang diperoleh dari analisis koefisien korelasi antara (X₁) modal kerja terhadap (X₂) penjualan sebesar 0.897 yang berarti antara variabel modal kerja terhadap penjualan mempunyai pengaruh yang sangat kuat. hasil analisis (X₂) penjualan terhadap (Y) return on asset sebesar 0.948 yang berarti antara variabel penjualan terhadap return on asset mempunyai hubungan yang sangat kuat dan positif.
Berdasarkan hasil analisis yang diperoleh dari analisis koefisien determinasi (X₁) modal kerja terhadap (X₂) penjualan pada PD. Sri Tanjung Indramayu adalah sebesar 80.46% sedangkan sisanya 19.54% diberikan oleh faktor lain yang tidak diteliti dalam penelitian ini. Analisis koefisien determinasi (X₂) penjualan terhadap (Y) return on asset pada PD. Sri Tanjung Indramayu adalah sebesar 89.87% sedangkan sisanya 10.13% diberikan oleh faktor lain yang tidak diteliti dalam penelitian ini.
Berdasarkan hasil perhitungan uji t ( X₁) terhadap (X₂) maka diperoleh nilai t_hitung sebesar 4.058 dan didapatkan nilai t_tabel sebesar 2.776 yang berarti karena t_hitung lebih besar dari t_tabel (4.058 > 2.776), maka HO di tolak dan Ha di terima, sehingga modal kerja berpengaruh terhadap penjualan. Perhitungan uji t (X₂) terhadap (Y) diperoleh nilai t_hitung sebesar 5.961 dan nilai t_tabel sebesar 2.776 karena t_hitung lebih besar dari t_tabel (5.961 > 2.776), maka H₂O di tolak dan H₂a di terima, sehingga menyatakan bahwa penjualan berpengaruh terhadap Return On asset pada PD. Sri Tanjung Indramayu
PARTISIPASI WARGANET DALAM MENGIDENTIFIKASI KOMUNIKASI INTELEKTUAL NARASUMBER POLITIK TERKAIT PERKEMBANGAN HASIL PEMILU 2019
Authors: Soelistyowati Dinar 
Published: December 2019

Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis bentuk komunikasi intelektual yang dinyatakan oleh narasumber politik terkait dengan perkembangan hasil Pemilu 2019. Pembahasan dalam penelitian ini meliputi gambaran umum mengenai euforia Pemilu 2019 yang berlanjut pada posisi komunikasi politik sebagai bagian dari intelektualitas narasumber politik, kemunculan media sosial dan jejaring sosial sebagai mediator baru warganet millenial, serta pengaruh warganet sebagai pengamat narasumber politik dalam membahas hasil perkembangan pemilu 2019. Pembahasan ini menggunakan pendekatan kualitatif yang menggunakan perpaduan antara teori semiotika dengan teori interaksionisme simbolik yang merupakan bagian dari paradigma konstruktivisme. Hasil dari penelitian ini menunjukkan bahwa pola komunikasi intelektual yang dibentuk oleh para narasumber politik terkait dengan perkembangan hasil Pemilu 2019 mampu berfungsi sebagai pemicu warganet untuk ikut berpartisipasi dengan menjadi bagian dari masyarakat yang melek informasi secara digital, juga mampu mengikuti dan menanti hasil dari perkembangan Pemilu 2019 demi terciptanya bangsa Indonesia yang lebih baik.
PEMANFAATAN GOOGLE CLASSROOM SEBAGAI MEDIA PEMBELAJARAN ONLINE DI UNIVERSITAS DIAN NUSWANTORO
Authors: Hapsari Swita Amallia , Pamungkas Heri 
Published: December 2019

Saat ini, literasi internet menjadi peran yang sangat penting untuk dikembangkan dalam kehidupan dasar kita. Oleh karena itu, sektor pendidikan perlu menggunakan teknologi informasi dalam proses pembelajaran di kampus. Google Classroom, adalah salahsatu akses gratis yang memudahkan dosen dalam proses e-learning. Lebih jauh, platform ini menawarkan banyak sekali keuntungan bagi penggunanya. Selain itu, platform ini dikenal sebagai alat yang mudah digunakan oleh pengguna smartphone atau laptop, serta mampu menciptakan peluang yang sama bagi semua siswa dan mendorong siswa untuk belajar lebih banyak tentang literasi internet. Penelitian ini menggunakan paradigma interpretif, dengan pendekatan kualitatif dan metode studi kasus untuk menemukan pemanfaatan Google Classroom oleh dosen Universitas Dian Nuswantoro khususnya di departemen Ilmu Komunikasi, pada kelas Pengolahan Konten Digital. Peran media baru di sektor pendidikan ini menghasilkan proses yang begitu mudah untuk dilakukan dan menunjukan bahwa hasil penyelesaiannya membutuhkan program pembelajaran campuran atau blended Learning dalam berkomunikasi yang baik di era digital.
FORMULATION AND DEVELOPMENT OF FAST DISSOLVING TABLET OF METOCLOPRAMIDE: AN ANTI-EMETIC DRUG
Authors: Carpenter Avilash , Gupta M.K. , Jain Neetesh Kumar , Sharma Urvashi , Sisodiya Rahul 
Published: December 2019

Aim: The main of the study is to formulate and develop orally disintegrating fast dissolving tablet of Metoclopramide hydrochloride.
Material & Methods: Before formulation and development of selected drug, the standard curve in buffer was prepared and absorbance at selected maxima was taken. Then two different disintegrating agents were selected and drug was mixed with disintegrating agents in different ratio. Various Preformulation parameters and evaluation of tablet i.e. disintegration time, dissolution time, friability, hardness, thickness were measured by standard procedure. Result & Discussion: The angle of repose for all the batches prepared. The values were found to be in the range of 30.46 to 36.45, which indicates good flow property for the powder blend according to the USP. The bulk density and tapped density for all the batches varied from 0.49 to 0.54 g/mL and 0.66 to 0.73, respectively. Carr’s index values were found to be in the range of 23.33 to 25.88, which is satisfactory for the powders as well as implies that the blends have good compressibility. Hausner ratio values obtained were in the range of 1.22 to 1.36, which shows a passable flow property for the powder blend based on the USP. The results for tablet thickness and height for all batches was found to range from 4.45 to 4.72 mm and 3.67 to 3.69 mm, respectively. Hardness or breaking force of tablets for all batches was found to range from 32.8 to 36.2 N. Tablet formulations must show good mechanical strength with sufficient hardness in order to handle shipping and transportation. Friability values for all the formulations were found to be in the range of 0.22 % to 0.30 %.
Conclusion: Orally disintegrating tablets were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The formulation was shown to have a rapid disintegration time that complied with the USP (less than one minute). The data obtained from the stability studies indicated that the orally disintegrating mini-tablets of MTH were stable under different environmental storage conditions.
Keywords: Formulation & Development, Fast Dissolving Tablet, Metoclopramide, Anti-Emetic Drug, Oral Disintegrating Tablet
FORMULATION AND EVALUATION OF TOPICAL GEL OF ACYCLOVIR FOR TREATMENT OF VIRAL DISEASE
Authors: Jatwa Vivek , Gupta M.K. , Jain Neetesh K , Sharma Urvashi , Sisodiya Rahul 
Published: December 2019

Aim: Formulation & Evaluation of Topical Gel of Acyclovir for Treatment of Viral Disease.
Material & Methods: Acyclovir gels were formulated using different polymers like Carbopol 934, Carbopol 940, hydroxy propyl methyl cellulose and Sodium Carboxy methyl cellulose. Different concentrations of polymer were used in the formulation of gels. All the formulations were evaluated for the various parameters.
Results & Discussion: Different formulations with use of different polymers were prepared. The amount and percentage of drug present in gel formulation using different polymers were estimated as per the procedure. The prepared gel using 1% carbopol- 934(A2) showed maximum drug content (101.72%) compared to other formulations. The spreadability of gels was determined as per the procedure. From spreadability data is observed that the formulation with 1.0% carbopol-934 showed maximum (8cm), where as the formulations with 1% carbopol-940, 3%, HPMC and Sodium CMC 3% were showed significant spreadability. 1.0 % carbopol-934 shows maximum release (74.59%). The addition of DMSO as permeation enhancer improves the drug release from gel formulation. 1.0% carbopol-940 also showed a similar release pattern, but the release was lesser. In case of HPMC and Sodium CMC gels the release was much lesser than carbopol gels. The addition of DMSO as permeation enhancer drug release was improved. Stability study for the best formulation was done as per the procedure. The gel was both physically and chemically stable at 4-50C, Room temperature and 37±50C.
Conclusion: From this investigation, it was concluded that formulation A2 with 1% Carbopol-934 may be the best formulation having good in vitro release profile, stability and bioavailability. Based on the results from the study further utility of the dosage form may depend on pharmacokinetic data. Forthcoming research work of antiviral activity may contribute in the challenging area.
Keywords: Acyclovir, Topical gel, Viral Disease, Skin Disease, Formulation & Development
Language outcome of very low birth weight babies at 2-year corrected age: A comparative study
Authors: Daniel Reeba Ann , George Babu 
Published: December 2019

Background: Improved survival of preterm infants has resulted in increase in motor and cognitive dysfunctions which have reduced health-related quality of life. Objective: The objective of this study was to assess the receptive and expressive language (EL) development of very low birth weight (VLBW) babies at 2-year corrected age and compare it with normal birth weight (NBW) “at-risk” babies on developmental follow-up. Materials and Methods: This was a cross-sectional study which compared the language outcome which was measured using Receptive-Expressive Emergent Language Scale. Results: The study included 75 VLBW babies and a comparison group of 26 NBW babies. The mean receptive language quotient in VLBW and NBW babies was 91.37±8.35 and 97.19±7.07, respectively (p=0.002). The mean EL quotient in VLBW and NBW babies was 82.64±12.32 and 92.77±10.47, respectively (p<0.001). A total of 20% of VLBW children had a significant delay in EL as opposed to only 4% of the NBW children (p=0.019). Conclusion: VLBW infants have a significantly higher chance of expressive language delay compared to NBW children.
Improving initiation of kangaroo mother care in a tertiary care hospital – A quality improvement initiative
Authors: Taduri Apoorva , Singh Himabindu , Lingaldinna Swapna , Namala Bharadwaj 
Published: December 2019

Background: Kangaroo mother care (KMC) is shown to be effective for thermal control, breastfeeding and bonding in all newborn infants, irrespective of setting, weight, gestational age, and clinical conditions. Objective: The objective of this study was to increase the percentage of initiation of KMC in stable low birth weight babies (<2000 g) admitted in special newborn care unit through a quality improvement (QI) approach in a tertiary care neonatal unit. Materials and Methods: Preterm mother-infant dyads who were admitted in the inborn Level 2 neonatal intensive care unit were enrolled in this study. The potential barriers for prolonged KMC were evaluated using fishbone analysis. A variety of measures (improving knowledge, attitude, and practices on KMC among health-care staff and mothers and other family members, information, education, and communication material on KMC in KMCroom, one-to-one structured counseling of mothers, modifying KMC registers, etc.) were introduced and subsequently tested by multiple Plan-Do-Study-Act cycles. Data on percentage of initiation of KMC were measured by bedside nurses on daily basis in each shift. Results: A total of 81 eligible mother-infant dyads were studied during implementation period (50 days). The mean weight and gestation of infants were 1364.9 g and 31.9 weeks, respectively. The percentage of initiation of KMC among eligible preterm infants has increased from a baseline of 16%–94.8% over a period of 8 weeks. Conclusion: Ongoing QI measures increased the percentage of initiation of KMC among eligible preterm infants from baseline of 16%–94.8% over a period of 8 weeks.
Recreational Leadership and Business Ethics: A Study on Animation Staff
Authors: DEMİRDAĞ Şerif Ahmet , GÜÇER Evren 
Published: December 2019

The
human factor in each service business has a very important position in
effectiveness, efficiency and achieving goals of establishments. The animation
department in the hotels plays also very important role so as to influence the
decision-making process of customers and their loyalty to hotels. However, the animation staff working in this
department should work in accordance with business ethics and morale as they
are in close contact with the consumer. Furthermore, the animation staff can be
considered as a “recreational leader” which leads to the recreational
activities in hotels. The aim of this research is to determine the relationship
between recreational leadership attitudes and views of business ethics of the
animation staff. For this purpose, the data is collected by questionnaire which
applied on 580 animateurs working in 65 resort hotels in Antalya, Muğla and
Aydın. According to results of analysis, there was a significant relationship
between recreational leadership attitude and business ethics of participants.
Impactos das teses e dissertações do Programa de Pós-Graduação em Ciência da Informação da UFMG:
Authors: Costa Belkiz , Oliveira Marlene , Araújo Ronaldo 
Published: December 2019

Pretendeu-se analisar os impactos acadêmico e social das teses e dissertações do Programa de Pós-graduação em Ciência da Informação da Universidade Federal de Minas Gerais, defendidas entre 2002 e 2018 e disponibilizadas na Biblioteca Digital de Teses e Dissertações da UFMG. A pesquisa caracteriza-se como descritiva, exploratória e de natureza quantitativa e qualitativa, usando métodos bibliométricos e altmétricos. A amostra foi composta por 296 dissertações e 150 teses. Utilizou-se o Google Scholar para mensurar o impacto acadêmico medido em citações e o gerenciador de referências Mendeley, para o impacto social compreendido nos indicadores de marcação e de contagem de leitores. Registrou-se que as 296 dissertações receberam 899 citações e as 150 teses receberam 1.013 citações no Google Scholar. Foram identificadas 60 dissertações e 40 teses marcadas no Mendeley. As dissertações acumularam um total de 295 leitores e as teses 410 leitores no Mendeley. O uso do Google Scholar e do Mendeley permitiu apontar o acesso e a visibilidade das teses e dissertações e um expressivo impacto acadêmico e social. Embora o acesso aberto tenha tornado as teses e dissertações mais acessíveis, ainda nota-se um pequeno índice de citação, tanto para as teses, quanto para as dissertações.
Influence of Varying Doses and Duration of Dietary Nitrates from Beetroot Juice on Sprint Performance in U.S. Army ROTC Cadets: A pilot study
Authors: Melton Michael , Kandiah Jayanthi 
Published: December 2019

Objective: Assess the effects of varying levels and duration of dietary nitrate supplementationfrom beetroot juice (BR) on sprint performance in army ROTC cadets.
Methods: Army Reserve Officer Training Corps (ROTC) cadets were randomly assigned to oneof three treatment groups: control (CON); low beetroot juice dose (BR1); and high BR juice –BR2. For 0, 6 and 15 days nitrate consumption from BR groups were as follows: CON receivedone 16.9 oz. bottle of apple juice (0 mg NO 3 -); BR1 received one can of BR juice (300 mg, 4.84mmol NO 3 -), and BR2 received 2 cans (16.8 oz.) BR (600 mg, 9.68 mmol NO 3 -). One week priorto the study, each cadet completed body composition measurements, predicted aerobic capacitymeasurements, and nutritional analysis via two 24-hour dietary recalls. Differences in primarymeasures (distance covered in the Yo-Yo IR1) were analyzed with two-way repeated measuresANOVA tests both between groups (CON, BR1, BR2) and within groups (0, 6, and day 15).Descriptive statistics and frequency counts were run on all remaining variables with a one-wayANOVA or t-test, including maximal heart rate during the YoYo IR1, dietary compliance, dailyblood pressure, juice compliance, and conditioning work-outs
Results: A dose-related enhancement with BR was observed; the data trended towardssignificance even in this small sample. A t-test revealed that there was a significant difference insprint performance by males and females overall at days 0, 6, 15 (p = 0.025, p = 0.005, p =0.004, respectively).
Conclusion: A single (300 mg, 4.84 mmol NO 3 ) or double (600 mg, 9.68 mmol NO 3 -) daily doseconsumption of BR appears to benefit ROTC cadets in athletic performance. Daily consumptionof BR benefitted ROTC males more than females. Results suggest BR supplementation could beadvantageous for sprint performance when administered for a longer duration (&gt; 15 days).
Monitoring System Building Plan For Risk Of Civil Office
Authors: Rahayu Sri , Faris Muhammad Rofi , Pane Asni Ramadani 
Published: December 2019

The development of increasingly rapid information technology requires companies to have a system that is able to provide data and information quickly and accurately. Tangerang Regency Education Office is a government agency in charge of controlling the education sector. In its business process, the Education Office still faces difficulties in obtaining reports on employment in periodic salary increases, because the system used is still using the help of Microsoft excel application software that is semi computerized, so that every data reported often has errors in providing civil servant salaries. Based on these problems Tangerang District Education Office is in dire need of an automated computer system that can control the regular salary increases of civil servants effectively and efficiently. As a tool to help in object-oriented programming language, Unified Modeling Language (UML) is used to describe the system, while data collection techniques use observation, interview, and literature study methods, so that the system can be monitored properly, effectively and efficiently using MySql databases, and PHP.
Keywords: Staffing, Periodic Salary Increase, Controlling, Web.