bluuebunny/crossref_metadata_2025_split huggingface dataset:
The multiplicity of logics, trust, and interdependence in donor‐imposed reporting practices in the nonprofit sector
Authors: Goncharenko Galina 
Published: May 2020

AbstractInstitutional donors occupy a privileged position among nongovernmental organization (NGO) stakeholders, which enables them to satisfy their accountability demands via donor‐imposed reporting in addition to official NGO information disclosures. This study explores the rationale behind the accountability demands of institutional donors and the utilization of donor‐imposed reporting for building, keeping, and strengthening NGO–donor relationships by examining a case of a Norwegian advocacy NGO and its five institutional donors. Real‐life constructs embedded in interview design are employed to contextualize the accounting data and expand the respondents’ perceptions by providing visibility to alternative scenarios of information provision. By approaching the topic through multi‐organizational perspectives, the study reveals the confluence and interdependence in symbiotic relationships of NGOs and their long‐term institutional donors, which are built through regular interorganizational interactions around imposed accountability demands and reporting requirements. The findings demonstrate that donors’ accountability demands are motivated by their vested interests in controlling, mitigating risk, legitimating grants’ provision, influencing NGO agendas, and obtaining trustworthy partners in the nonprofit sector. The analysis reveals that the types of demands donors impose are determined by institutional logics embedded in their own organisational practices, ideologies, and patterns of governance. The multiplicity of implied donor logics requires NGOs to adjust their identities as the notions of familiarity, compliance, and consonance with these logics would signal NGOs’ trustworthiness and reliability and assist in securitization of long‐term funding. Finally, the study discusses the implications of the multiplicity of donors’ logics and imposed requirements for the accountability and reporting practices in the nonprofit sector.
Commonality in liquidity and multilateral trading facilities
Authors: Jain Pankaj K. , Mekhaimer Mohamed , Mortal Sandra 
Published: May 2020

AbstractWe use the introduction of two multilateral trading facilities (MTFs) to examine the impact of market fragmentation on commonality in liquidity. We find that the introduction of MTFs following the Markets in Financial Instruments Directive increases the comovement of stocks’ liquidity with MTF liquidity, while the comovement with the home market liquidity generally decreases. We also find that the higher the MTF trading volume or the number of MTFs trading a stock, the stronger the effect. Further, we find that the commonality in liquidity remains unchanged for a matched control sample of stocks that do not trade on MTFs.
Anti‐cancer therapy made easier: a 25‐year update
Authors: Davies Amy , Lum Caroline , Raju Rachel , Ansell Evan , Webber Kate , Segelov Eva 
Published: May 2020

AbstractIn 1993, the Internal Medicine Journal published ‘Chemotherapy made easier’, outlining developments in supportive care of patients undergoing chemotherapy. This described the contemporary state of anti‐emetics, colony stimulating factors, cardiac toxicity, neurotoxicity, development of drug analogues and venous access devices. Twenty‐five years later, we update the measures that improve the tolerability of the plethora of new anti‐cancer therapies, which have extended well beyond traditional chemotherapy agents to include immunotherapy and targeted therapies. Optimisation of supportive care is paramount to allow safe delivery with the least possible impact on quality of life of these new treatments, many of which have resulted dramatically improved outcomes across multiple cancer types. This state of the art update summarises advances in supportive care therapies relating to improving the patient experience during and after anti‐cancer treatment, including new anti‐emetics, hair preservation techniques, bone marrow support and improved venous access devices; the ongoing challenge of neurotoxicity; and the advent of multidisciplinary sub‐specialised fields such as cardio‐oncology and oncofertility. Supportive care medications for immuno‐oncology therapies is a new section; these highly effective (although not universally so) agents were a mere illusion in 1993.
Impact of Victoria's first dedicated endocrine hypertension service on the pattern of primary aldosteronism diagnoses
Authors: Lim Yin Yu , Libianto Renata , Shen Jimmy , Young Morag J. , Fuller Peter J. , Yang Jun 
Published: May 2020

AbstractBackgroundPrimary aldosteronism (PA) accounts for 3.2–12.7% of hypertension in primary care but is often diagnosed late, if at all. A delayed or missed diagnosis leads to poor blood pressure control and greater cardiovascular risk.AimsTo analyse the impact of Victoria's first dedicated endocrine hypertension service (EHS) on the pattern of PA diagnosis.MethodsSocio‐demographic and clinical data from all patients who attended the EHS since July 2016 (n = 267) was collected prospectively. Patients were divided into Year 1 (Y1), Year 2 (Y2) and Year 3 (Y3), based on their first visit.ResultsThe proportion of primary care referrals increased (20% in Y1, 47% in Y2, 52% in Y3) with more referrals being made for treatment‐naive hypertension (3% in Y1, 14% in Y2, 19% in Y3). Among PA patients, the median duration of hypertension prior to their first visit decreased (11 years in Y1, 10 years in Y2, 7 years in Y3), and the prevalence of end‐organ damage decreased (44% in Y1, 42% in Y2, 33% in Y3). Targeted management of PA improved clinical and biochemical outcomes. The average blood pressure reduction following targeted management increased from 16/12 mmHg in Y1 to 23/12 mmHg in Y3.ConclusionThe EHS, with its strong component of general practitioner engagement, led to increased primary care referrals and PA detection earlier in the course of hypertension. Referred patients were on fewer antihypertensives and had less end‐organ damage which simplified the diagnostic process, allowing targeted treatment to be commenced earlier and patient outcomes optimised.
Detection of runs of homozygosity in conserved and commercial pig breeds in Poland
Authors: Szmatoła Tomasz , Jasielczuk Igor , Semik‐Gurgul Ewelina , Szyndler‐Nędza Magdalena , Blicharski Tadeusz , Szulc Karolina , Skrzypczak Ewa , Gurgul Artur 
Published: May 2020

AbstractRuns of homozygosity (ROH) are continuous segments of the genome that arose as a result of inbreeding, resulting in the inheritance of identical haplotypes from both parents who shared a common ancestor. In the present study, we performed a detailed characterization and comparison of ROH in four pig breeds, including intensively selected Polish Landrace as well as native unselected animals of Puławska and two Złotnicka breeds (White and Spotted). We used a medium‐density PorcineSNP60 BeadChip assay (Illumina) and cgaTOH software to detect ROH covering a minimum of 30 adjacent SNPs and maintaining a size over 1 Mb. By analysing ROH distribution and frequency across the genome, we also identified genomic regions with high ROH frequency (so‐called “ROH hotspots”). The obtained results showed that the analysed conserved breeds were characterized by a higher ROH span and higher ROH‐based inbreeding coefficients (FROH), which likely result from past population bottlenecks, increasing the overall inbreeding level within these populations. The analysis of ROH distribution across the genomes revealed the presence of both shared and breed‐specific ROH hotspots. These hotspots, presumably representing genome regions under selection, overlapped with a variety of genes associated with processes connected with immune system functioning, reproduction, glucose homeostasis and metabolism. The genome regions with ROH hotspots overlapping in all analysed populations, located on SSC4 (51.9–55.9 Mb) and 13 (92.6–97.8 Mb), covered thirty‐one different genes, including MMP16, SLC7A13, ATP6V0D2, CNGB3, WWiP1, RiMDN1 and CPNE3. These genes are primarily associated with biological regulation and metabolism, processes that could be responsible for the variety of the selected production and functional features.
Blood pressure target for hypertension in chronic kidney disease: One size does not fit all
Authors: Kollias Anastasios , Kyriakoulis Konstantinos G. , Stergiou George S. 
Published: May 2020

AbstractThere is disagreement between the American and the European guidelines for hypertension management in regard to the optimal blood pressure target in patients with chronic kidney disease (CKD). Randomized clinical trials and meta‐analyses of individual patient data pooled from these trials do not clearly support an intensive blood pressure target for the entire population of CKD patients with hypertension. However, some evidence suggests that in CKD patients with proteinuria strict blood pressure control might confer benefit in terms of renal outcome. Tailored treatment strategy based on the individual’s proteinuric profile and tolerability along with standardization of blood pressure measurement methodology including out‐of‐office evaluation are of paramount importance in patients with CKD.
Genome‐wide DNA methylation patterns associated with sleep and mental health in children: a population‐based study
Authors: Koopman‐Verhoeff Maria Elisabeth , Mulder Rosa H. , Saletin Jared M. , Reiss Irwin , van der Horst Gijsbertus T.J. , Felix Janine F. , Carskadon Mary A. , Tiemeier Henning , Cecil Charlotte A.M. 
Published: May 2020

BackgroundDNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population.MethodsThis cross‐sectional study included 465 10‐year‐old children (51.3% female) from the Generation R Study. Genome‐wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self‐report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11‐year‐old children to calculate sleep duration and midpoint sleep. Weighted gene co‐expression network analysis was used to identify highly comethylated DNAm ‘modules’, which were tested for associations with sleep and mental health outcomes.ResultsWe identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT – a key regulator of Tau proteins in the brain involved in neuronal function – as well as genes previously implicated in sleep duration. Follow‐up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood–brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health.ConclusionsWe identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep.
Trajectories of autistic social traits in childhood and adolescence and disordered eating behaviours at age 14 years: A UK general population cohort study
Authors: Solmi Francesca , Bentivegna Francesca , Bould Helen , Mandy William , Kothari Radha , Rai Dheeraj , Skuse David , Lewis Glyn 
Published: May 2020

BackgroundSome people with eating disorders have difficulties with social communication. However, no longitudinal evidence regarding the direction of this association exists. We investigated trajectories of autistic social traits across childhood and adolescence in adolescents with and without disordered eating behaviours in early adolescence.MethodsWe used data from the Avon Longitudinal Study of Parents and Children. Our disordered eating measure indicated presence of any, monthly and weekly disordered eating (fasting, purging, dieting, binge eating) at age 14 years. Autistic social traits were reported by mothers using the Social and Communication Disorders Checklist (SCDC) at age seven, 11, 14 and 16 years. We modelled SCDC score trajectories using multilevel negative binomial models adjusting for a number of child‐ and maternal‐level confounders.ResultsOf the 5,381 adolescents included in our sample, 421 (7.8%) experienced one or more disordered eating behaviours, and 148 (2.8%) weekly episodes. Adolescents with disordered eating had a 20% increase in SCDC scores (relative risk (RR) 1.23, 95% confidence interval (CI):1.14, 1.32) compared to those without disordered eating. This association was particularly apparent for those reporting weekly (RR 1.43, 95%CI: 1.27, 1.61) as opposed to monthly disordered eating (RR 1.12, 95%CI: 1.01, 1.22).ConclusionsGreater autistic social traits in childhood could represent a risk factor for the development of disordered eating in adolescence. Although mechanisms of this association need to be elucidated, clinicians should be aware that autistic social traits could have predated the eating disorder when managing people with these conditions.
Population pharmacokinetics of ethanamizuril in normal and coccidiosis‐infected chickens through ultra‐performance liquid chromatography–Tandem Mass Spectrometry
Authors: Wang Xiaoyang , Zhang Keyu , Wang Mi , Zhang Lifang , Fei Chenzhong , Wang Chunmei , Liu Yingchun , Xue Feiqun , Hang Taijun 
Published: May 2020

AbstractEthanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two‐compartment model with first‐order absorption after oral administration in chickens. Its clearance rate and volumn of central compartment distribution (Vc) were affected by age and body weight, and volumn of central compartment distribution (Vc) and volume of peripheral compartment distribution(Vp) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.
Use of complementary and alternative medicine treatments by mothers of children with developmental disabilities: a cross sectional study
Authors: Konuk Sener Dilek , Karaca Aysel 
Published: May 2020

AbstractThis study aims to determine the rates of complementary and alternative medicine methods used by mothers of children with developmental disabilities, reasons for using methods, and comparison of methods according to diagnosis groups. The cohort in this cross‐sectional and correlational study consisted of the mothers of 390 students with developmental disabilities; 77.2% of the mothers reported using at least one complementary and alternative medicine treatment. The highest level of use was found in the groups of mothers of children with cerebral palsy (100%) and autism spectrum disorder (88.5%). The most commonly used treatments were biological therapies consisting of special diets and multivitamins, manipulative and body‐based methods including massage and exercise, and mind–body interventions such as prayer, wearing amulets, and seeking help from a Muslim preacher (hodja). However, mothers never used alternative medicine treatments such as homeopathy, acupuncture, or Ayurveda, nor did they use energy‐based healing techniques such as reiki, tai chi, yoga, kinesiology, or neurofeedback exercises. Health care professionals, especially nurses as health care team members, should be knowledgeable and careful about the benefits, side effects, administration methods, and contraindications of complementary and alternative medicine treatments.
Determinants of the difficulty of leadless pacemaker implantation
Authors: Garweg Christophe , Vandenberk Bert , Foulon Stefaan , Hermans Patrick , Poels Patricia , Haemers Peter , Ector Joris , Willems Rik 
Published: May 2020

AbstractBackgroundThe Micra Transcatheter Pacing System is implanted directly in the right ventricle (RV) through the femoral vein using a steerable transcatheter delivery system. The present study was done to identify determinants of difficult leadless pacemaker implant procedures including operator, patient, and RV anatomical characteristics.MethodsAll patients who underwent a Micra implant from July 2015 to December 2018 at our center were analyzed. From an RV angiogram acquired during implantation, RV geometry including systolic and diastolic volumes and ejection fraction was characterized. The presence of septomarginal trabeculation was noted.ResultsOne hundred twenty‐six patients (mean age: 79 ± 11 years old, mostly male: 77%) were enrolled. Mean Micra RV implant procedure time was 24 ± 23 min, with 1.7 ± 1.3 deployments of the device. No significant change in implant procedure time was observed after the first 30 implants. Eleven patients had a prominent septal component of the septomarginal trabeculation in the RV. Univariate analysis showed that the procedure time was positively correlated with the presence of a prominent septal component of the septomarginal trabeculation (P < .001) or an episode of heart failure (P = .02) and negatively correlated with the number of procedures performed by the operator (P < .001). After multivariable analysis, only the presence of a prominent septal component of the septomarginal trabeculation (P < .001) and the number of procedures performed by the operator (P < .001) were associated with the implant procedure time.ConclusionsIn our experience, implant procedure time of a Micra leadless pacemaker depended on the presence of a prominent septal component of the septomarginal trabeculation and operator experience.
Metabolomic markers and physiological adaptations for high phosphate utilization efficiency in rice
Authors: Watanabe Mutsumi , Walther Dirk , Ueda Yoshiaki , Kondo Katsuhiko , Ishikawa Satoru , Tohge Takayuki , Burgos Asdrubal , Brotman Yariv , Fernie Alisdair R , Hoefgen Rainer , Wissuwa Matthias 
Published: May 2020

AbstractUtilizing phosphate more efficiently is crucial for sustainable crop production. Highly efficient rice (Oryza sativa) cultivars have been identified and this study aims to identify metabolic markers associated with P utilization efficiency (PUE). P deficiency generally reduced leaf P concentrations and CO2 assimilation rates but efficient cultivars were reducing leaf P concentrations further than inefficient ones while maintaining similar CO2 assimilation rates. Adaptive changes in carbon metabolism were detected but equally in efficient and inefficient cultivar groups. Groups furthermore did not differ with respect to partial substitutions of phospholipids by sulfo‐ and galactolipids. Metabolites significantly more abundant in the efficient group, such as sinapate, benzoate and glucoronate, were related to antioxidant defence and may help alleviating oxidative stress caused by P deficiency. Sugar alcohols ribitol and threitol were another marker metabolite for higher phosphate efficiency as were several amino acids, especially threonine. Since these metabolites are not known to be associated with P deficiency, they may provide novel clues for the selection of more P efficient genotypes. In conclusion, metabolite signatures detected here were not related to phosphate metabolism but rather helped P efficient lines to keep vital processes functional under the adverse conditions of P starvation.
Chilblain‐like lesions in children following suspected COVID‐19 infection
Authors: Colonna Cristiana , Monzani Nicola Adriano , Rocchi Alessia , Gianotti Raffaele , Boggio Francesca , Gelmetti Carlo 
Published: May 2020

AbstractDuring the COVID‐19 pandemic, chilblain‐like lesions have been reported in mildly symptomatic children and adolescents. We present four children investigated for suspected COVID‐19 infection who presented with acral skin findings and mild systemic symptoms. Histology from one case showed signs of vasculitis with evident fibrin thrombus.
The nature of perceptual constancies
Authors: Schulte Peter 
Published: May 2020

AbstractPerceptual constancies have been studied by psychologists for decades, but in recent years, they have also become a major topic in the philosophy of mind. One reason for this surge of interest is Tyler Burge’s (2010) influential claim that constancy mechanisms mark the difference between perception and mere sensitivity, and thereby also the difference between organisms with genuine representational capacities and ‘mindless’ beings. Burge’s claim has been the subject of intense debate. It is becoming increasingly clear, however, that we cannot hope to settle this debate (as well as related debates in the philosophy of mind) without a clear and substantive theoretical account of what perceptual constancies are. In the first part of this paper, I argue that the standard definitions in the literature fall short of providing such an account. Still, as I aim to show in the second part of the paper, by taking a closer look at some of the paradigm examples, it is possible to construct a plausible general account of perceptual constancies that is both clear and substantive, and that can serve as a firm foundation for settling debates like the dispute about Burge’s ‘constancy mechanism criterion’ for perception.
Inference for Two-Stage Sampling Designs
Authors: Chauvet Guillaume , Vallée Audrey-Anne 
Published: May 2020

SummaryTwo-stage sampling designs are commonly used for household and health surveys. To produce reliable estimators with associated confidence intervals, some basic statistical properties like consistency and asymptotic normality of the Horvitz–Thompson estimator are desirable, along with the consistency of associated variance estimators. These properties have been mainly studied for single-stage sampling designs. In this work, we prove the consistency of the Horvitz–Thompson estimator and of associated variance estimators for a general class of two-stage sampling designs, under mild assumptions. We also study two-stage sampling with a large entropy sampling design at the first stage and prove that the Horvitz–Thompson estimator is asymptotically normally distributed through a coupling argument. When the first-stage sampling fraction is negligible, simplified variance estimators which do not require estimating the variance within the primary sampling units are proposed and shown to be consistent. An application to a panel for urban policy, which is the initial motivation for this work, is also presented.
Generalized Partially Linear Models on Riemannian Manifolds
Authors: Simó Amelia , Victoria Ibáñez M. , Epifanio Irene , Gimeno Vicent 
Published: May 2020

SummaryWe introduce generalized partially linear models with covariates on Riemannian manifolds. These models, like ordinary generalized linear models, are a generalization of partially linear models on Riemannian manifolds that allow for scalar response variables with error distribution models other than a normal distribution. Partially linear models are particularly useful when some of the covariates of the model are elements of a Riemannian manifold, because the curvature of these spaces makes it difficult to define parametric models. The model was developed to address an interesting application: the prediction of children's garment fit based on three-dimensional scanning of their bodies. For this reason, we focus on logistic and ordinal models and on the important and difficult case where the Riemannian manifold is the three-dimensional case of Kendall's shape space. An experimental study with a well-known three-dimensional database is carried out to check the goodness of the procedure. Finally, it is applied to a three-dimensional database obtained from an anthropometric survey of the Spanish child population. A comparative study with related techniques is carried out.