bluuebunny/crossref_metadata_2025_split huggingface dataset:
The earthquake arrest zone
Authors: Ke Chun-Yu , McLaskey Gregory C , Kammer David S 
Published: August 2020

SUMMARY
Earthquake ruptures are generally considered to be cracks that propagate as fracture or frictional slip on pre-existing faults. Crack models have been used to describe the spatial distribution of fault offset and the associated static stress changes along a fault, and have implications for friction evolution and the underlying physics of rupture processes. However, field measurements that could help refine idealized crack models are rare. Here, we describe large-scale laboratory earthquake experiments, where all rupture processes were contained within a 3-m long saw-cut granite fault, and we propose an analytical crack model that fits our measurements. Similar to natural earthquakes, laboratory measurements show coseismic slip that gradually tapers near the rupture tips. Measured stress changes show roughly constant stress drop in the centre of the ruptured region, a maximum stress increase near the rupture tips and a smooth transition in between, in a region we describe as the earthquake arrest zone. The proposed model generalizes the widely used elliptical crack model by adding gradually tapered slip at the ends of the rupture. Different from the cohesive zone described by fracture mechanics, we propose that the transition in stress changes and the corresponding linear taper observed in the earthquake arrest zone are the result of rupture termination conditions primarily controlled by the initial stress distribution. It is the heterogeneous initial stress distribution that controls the arrest of laboratory earthquakes, and the features of static stress changes. We also performed dynamic rupture simulations that confirm how arrest conditions can affect slip taper and static stress changes. If applicable to larger natural earthquakes, this distinction between an earthquake arrest zone (that depends on stress conditions) and a cohesive zone (that depends primarily on strength evolution) has important implications for how seismic observations of earthquake fracture energy should be interpreted.
Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease
Authors: Wright Galen E B , Caron Nicholas S , Ng Bernard , Casal Lorenzo , Casazza William , Xu Xiaohong , Ooi Jolene , Pouladi Mahmoud A , Mostafavi Sara , Ross Colin J D , Hayden Michael R 
Published: August 2020

AbstractHuntington disease (HD) is a neurodegenerative disorder that is caused by a CAG repeat expansion in HTT. The length of this repeat, however, only explains a proportion of the variability in age of onset in patients. Genome-wide association studies have identified modifiers that contribute toward a proportion of the observed variance. By incorporating tissue-specific transcriptomic information with these results, additional modifiers can be identified. We performed a transcriptome-wide association study assessing heritable differences in genetically determined expression in diverse tissues, with genome-wide data from over 4000 patients. Functional validation of prioritized genes was undertaken in isogenic HD stem cells and patient brains. Enrichment analyses were performed with biologically relevant gene sets to identify the core pathways. HD-associated gene coexpression modules were assessed for associations with neurological phenotypes in an independent cohort and to guide drug repurposing analyses. Transcriptomic analyses identified genes that were associated with age of HD onset and displayed colocalization with gene expression signals in brain tissue (FAN1, GPR161, PMS2, SUMF2), with supporting evidence from functional experiments. This included genes involved in DNA repair, as well as novel-candidate modifier genes that have been associated with other neurological conditions. Further, cortical coexpression modules were also associated with cognitive decline and HD-related traits in a longitudinal cohort. In summary, the combination of population-scale gene expression information with HD patient genomic data identified novel modifier genes for the disorder. Further, these analyses expanded the pathways potentially involved in modifying HD onset and prioritized candidate therapeutics for future study.
SAY NO to mild ovarian stimulation for all poor responders: it is time to realize that not all poor responders are the same
Authors: Polyzos N P , Popovic-Todorovic B 
Published: August 2020

ABSTRACT
Over the last 25 years, a vast body of literature has been published evaluating different treatment modalities for the management of poor ovarian responders. Despite the evidence that maximizing ovarian response can improve the chances of live born babies in poor responders, there are still voices suggesting that all poor responders are the same, irrespective of their age and their actual ovarian reserve. This has resulted in the suggestion of adopting a mild ovarian stimulation approach for all poor responders, based on the results of several trials which failed to identity differences when comparing mild and more intense stimulation in predicted poor responders. The current article analyzes in detail these studies and discusses the shortcomings in terms of type of population included, outcomes and settings performed, which may actually be responsible for the belief that only mild stimulation should be used. In the era of individualization in medicine, it must be realized that there are subgroups of predicted poor responders who will benefit from an individual rather than ‘one fits all’ mild stimulation approach and thus we should provide the same standard of treatment for all our poor responder patients.
Spacetime Positive Mass Theorems for Initial Data Sets with Non-Compact Boundary
Authors: Almaraz Sérgio , de Lima Levi Lopes , Mari Luciano 
Published: August 2020

AbstractIn this paper, we define an energy-momentum vector at the spatial infinity of either asymptotically flat or asymptotically hyperbolic initial data sets carrying a non-compact boundary. Under suitable dominant energy conditions (DECs) imposed both on the interior and along the boundary, we prove the corresponding positive mass inequalities under the assumption that the underlying manifold is spin. In the asymptotically flat case, we also prove a rigidity statement when the energy-momentum vector is light-like. Our treatment aims to underline both the common features and the differences between the asymptotically Euclidean and hyperbolic settings, especially regarding the boundary DECs.
Stage III disease of ovarian, tubal and peritoneal cancers can be accurately diagnosed with pre-operative CT. Japan Clinical Oncology Group Study JCOG0602
Authors: Onda Takashi , Tanaka Yumiko Oishi , Kitai Satomi , Manabe Tomoko , Ishikawa Mitsuya , Hasumi Yoko , Miyamoto Kenichi , Ogawa Gakuto , Satoh Toyomi , Saito Toshiaki , Kasamatsu Takahiro , Nakanishi Toru ,   Japan Clinical Oncology Group
Published: August 2020

Abstract

Purpose
Computed tomography of the abdomen and pelvis is a useful imaging modality for identifying origin and extent of ovarian cancer before primary debulking surgery. However, the International Federation of Gynecology and Obstetrics staging for ovarian cancer is determined based on surgico-pathological findings. The purpose of this study is to determine whether computed tomography staging can be the surrogate for surgico-pathological International Federation of Gynecology and Obstetrics staging in advanced ovarian cancer undergoing neoadjuvant chemotherapy.

Methods
Computed tomography staging was compared with surgico-pathological International Federation of Gynecology and Obstetrics staging in primary debulking surgery arm patients in a randomized controlled trial comparing primary debulking surgery and neoadjuvant chemotherapy (JCOG0602). The cancer of primary debulking surgery arm was identically diagnosed regarding the origin and extent with the cancer of neoadjuvant chemotherapy arm before accrual, using imaging studies (computed tomography and/or magnetic resonance imaging), cytological examination (ascites, pleural effusion or tumor contents fluid) and tumor marker (CA125 &gt; 200 U/mL and CEA &lt; 20 ng/mL). Institutional computed tomography staging was also compared with computed tomography staging by central review.

Results
Among 149 primary debulking surgery arm patients, 147 patients who underwent primary debulking surgery immediately were analyzed. Positive predictive values and sensitivity of computed tomography staging for surgical stage III disease (extra-pelvic peritoneal disease and/or retroperitoneal lymph node metastasis) were 99%. Meanwhile, positive predictive values for the presence of small (≤2 cm) extra-pelvic peritoneal disease were low; &lt;20% in omentum. Accuracy of institutional computed tomography staging was comparable with computed tomography staging by central review.

Conclusions
Preoperative computed tomography staging in each institution can be the surrogate for surgico-pathological diagnosis in stage III disease of ovarian cancer patients undergoing neoadjuvant chemotherapy without diagnostic surgery, but reliability of diagnosis of stage IIIB disease is inadequate.
Clinical trial registration: UMIN000000523(UMIN-CTR).
Cancer Care Evaluation Scale (CCES): measuring the quality of the structure and process of cancer care from the perspective of patients with cancer
Authors: Masukawa Kento , Sato Kazuki , Shimizu Megumi , Morita Tatsuya , Miyashita Mitsunori 
Published: August 2020

Abstract

Objective
To evaluate the quality of the structure and process of cancer care from the perspective of patients with cancer, we developed a Cancer Care Evaluation Scale.

Methods
Two anonymous online surveys of patients with cancer in Japan were conducted using a convenience sample of 400 adult cancer outpatients.

Results
In total, 162 patients participated in the online surveys. Factor analysis revealed that the Cancer Care Evaluation Scale had the following 12 domains: (i) relationship with physician, (ii) relationship with nurse, (iii) physical care by physician, (iv) physical care by nurse, (v) psycho-existential care, (vi) help with decision-making for patients, (vii) coordination and consistency, (viii) environment, (ix) cost, (x) availability, (xi) care for the side effects of cancer treatment by a physician, and (xii) care for the side effects of cancer treatment by a nurse. The Cancer Care Evaluation Scale was correlated with overall care satisfaction (r = 0.75), but not with the quality of life (r = 0.40). In regard to rest–retest reliability, most items showed an intraclass correlation coefficient of 0.7 or higher.

Conclusion
The validity and reliability of the Cancer Care Evaluation Scale were confirmed, suggesting that this tool is useful for evaluating the quality of cancer care from the perspective of patients with cancer.
COVID-19 emergency measures and the impending authoritarian pandemic
Authors: Thomson Stephen , Ip Eric C 
Published: August 2020

ABSTRACT
COVID-19 has brought the world grinding to a halt. As of early August 2020, the greatest public health emergency of the century thus far has registered almost 20 million infected people and claimed over 730,000 lives across all inhabited continents, bringing public health systems to their knees, and causing shutdowns of borders and lockdowns of cities, regions, and even nations unprecedented in the modern era. Yet, as this Article demonstrates—with diverse examples drawn from across the world—there are unmistakable regressions into authoritarianism in governmental efforts to contain the virus. Despite the unprecedented nature of this challenge, there is no sound justification for systemic erosion of rights-protective democratic ideals and institutions beyond that which is strictly demanded by the exigencies of the pandemic. A Wuhan-inspired all-or-nothing approach to viral containment sets a dangerous precedent for future pandemics and disasters, with the global copycat response indicating an impending ‘pandemic’ of a different sort, that of authoritarianization. With a gratuitous toll being inflicted on democracy, civil liberties, fundamental freedoms, healthcare ethics, and human dignity, this has the potential to unleash humanitarian crises no less devastating than COVID-19 in the long run.
Oncologists’ Reluctance to Use the Terms Hope and Cure: A Bibliometric Analysis of Articles From Two High-Impact Oncology Journals
Authors: Corn Benjamin W , Feldman David , Schapira Lidia , Steensma David P , Loprinzi Charles L , Bian Jiang 
Published: August 2020

Abstract
The words cure and hope are important terms in oncology, reflecting a balance of aspirations and realism for physicians and patients. Yet, some have suggested that oncologists are reluctant to use these terms. We tested this hypothesis by performing a bibliometric analysis of the frequency of use of these words in JAMA Oncology (JAMA Oncol) and the Journal of Clinical Oncology (JCO). The text of all articles in 3 categories—primary research, editorials, and narrative essays—appearing in JCO from 2000 to 2018 and in JAMA Oncol from 2015 to 2019 was analyzed. These analyses compared, across these categories, the proportion of articles containing the words cure and hope, as well as the proportion of total sentences containing these words. There were statistically significant differences in frequency of the use of the terms cure and hope as a function of the type of article published in the JCO and JAMA Oncol (2-sided P values ranging from .005 to &lt;.001). Results were similar for both journals, with minor exceptions. Both hope and cure were used in a greater number of articles and sentences in the narrative and editorial categories than in primary research. Moreover, hope was used more often in narrative essays than in editorials. The relative reluctance to use these terms in more scientifically oriented original reports, despite concomitant improvements in oncologic outcomes, may reflect a bias worthy of future exploration.
Central venous catheter placement leading to an emergent paramedian sternotomy: a case report
Authors: Cooley-Rieders Keaton , Donayre Carlos E , Nelson Ariana M 
Published: August 2020

Abstract
Perioperative cardiac tamponade during central venous catheter placement is rare. We present a case of tamponade from pulmonary artery injury during dialysis catheter placement resulting in complicated sternotomy and hospital course. A 52-year-old female experienced intraoperative hypotension, rapidly identified as tamponade, that was treated with an emergent paramedian sternotomy. Patient experienced postdischarge dehiscence and osteomyelitis requiring multiple reoperations. This case is the first report of a deviated paramedian sternotomy performed mainly through ribs. The complications experienced outline the importance of effective multidisciplinary knowledge of best practices to stabilize tamponade pathology, mitigating morbidity and mortality.
Core-collapse supernovae in binaries as the origin of galactic hyper-runaway stars
Authors: Evans F A , Renzo M , Rossi E M 
Published: August 2020

ABSTRACT
Several stars detected moving at velocities near to or exceeding the Galactic escape speed likely originated in the Milky Way disc. We quantitatively explore the ‘binary supernova scenario’ hypothesis, wherein these ‘hyper-runaway’ stars are ejected at large peculiar velocities when their close, massive binary companions undergo a core-collapse supernova and the binary is disrupted. We perform an extensive suite of binary population synthesis simulations evolving massive systems to determine the assumptions and parameters that most impact the ejection rate of fast stars. In a simulation tailored to eject fast stars, we find the most likely hyper-runaway star progenitor binary is composed of a massive (${\sim}30\, \mathrm{ M}_{\odot }$) primary and an ${\sim}3\!-\!4\, \mathrm{ M}_{\odot }$ companion on an orbital period that shrinks to ≲1 d prior to the core collapse following a common-envelope phase. The black hole remnant formed from the primary must receive a natal kick ≳1000 km s−1 to disrupt the binary and eject the companion at a large velocity. We compare the fast stars produced in these simulations to a contemporary census of early-type Milky Way hyper-runaway star candidates. We find that these rare objects may be produced in sufficient number only when poorly constrained binary evolution parameters related to the strength of post-core-collapse remnant natal kicks and common-envelope efficiency are adjusted to values currently unsupported – but not excluded – by the literature. We discuss observational implications that may constrain the existence of these putative progenitor systems.
Central velocity dispersion catalogue of LAMOST-DR7 galaxies
Authors: Napolitano Nicola R , D’Ago Giuseppe , Tortora Crescenzo , Zhao Gang , Luo A-Li , Tang Baitian , Zhang Wei , Zhang Yong , Li Rui 
Published: August 2020

ABSTRACT
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) is a major facility to carry out spectroscopic surveys for cosmology and galaxy evolution studies. The seventh data release of the LAMOST ExtraGAlactic Survey (LEGAS) is currently available and including redshifts of 193 361 galaxies. These sources are spread over $\sim 11\, 500$ deg2 of the sky, largely overlapping with other imaging (SDSS and HSC) and spectroscopic (BOSS) surveys. The estimated depth of the galaxy sample, r ∼ 17.8, the high signal-to-noise ratio, and the spectral resolution R = 1800, make the LAMOST spectra suitable for galaxy velocity dispersion (VD) measurements, which are invaluable to study the structure and formation of galaxies and to determine their central dark matter content. We present the first estimates of central VD of $\sim 86\, 000$ galaxies in LAMOST footprint. We have used a wrap-up procedure to perform the spectral fitting using ppxf, and derive VD measurements. Statistical errors are also assessed by comparing LAMOST VD estimates with the ones of SDSS and BOSS over a common sample of $\sim 51\, 000$ galaxies. The two data sets show a good agreement, within the statistical errors, in particular when VD values are corrected to 1 effective radius aperture. We also present a preliminary mass–σ relation and find consistency with previous analyses based on local galaxy samples. These first results suggest that LAMOST spectra are suitable for galaxy VD measurements to complement the available catalogues of galaxy internal kinematics in the Northern hemisphere. We plan to expand this analysis to next LAMOST data releases.
The SAMI galaxy survey: a range in S0 properties indicating multiple formation pathways
Authors: Deeley Simon , Drinkwater Michael J , Sweet Sarah M , Diaz Jonathan , Bekki Kenji , Couch Warrick J , Forbes Duncan A , Bland-Hawthorn Joss , Bryant Julia J , Croom Scott , Cortese Luca , Lawrence Jon S , Lorente Nuria , Medling Anne M , Owers Matt , Richards Samuel N , van de Sande Jesse 
Published: August 2020

ABSTRACT
It has been proposed that S0 galaxies are either fading spirals or the result of galaxy mergers. The relative contribution of each pathway and the environments in which they occur remain unknown. Here, we investigate stellar and gas kinematics of 219 S0s in the SAMI Survey to look for signs of multiple formation pathways occurring across the full range of environments. We identify a large range of rotational support in their stellar kinematics, which correspond to ranges in their physical structure. We find that pressure-supported S0s with v/σ below 0.5 tend to be more compact and feature misaligned stellar and gas components, suggesting an external origin for their gas. We postulate that these S0s are consistent with being formed through a merger process. Meanwhile, comparisons of ellipticity, stellar mass, and Sérsic index distributions with spiral galaxies show that the rotationally supported S0s with v/σ above 0.5 are more consistent with a faded spiral origin. In addition, a simulated merger pathway involving a compact elliptical and gas-rich satellite results in an S0 that lies within the pressure-supported group. We conclude that two S0 formation pathways are active, with mergers dominating in isolated galaxies and small groups, and the faded spiral pathway being most prominent in large groups ($10^{13}\lt \rm {M_{halo}}\lt 10^{14}$).
Resolving small-scale cold circumgalactic gas in TNG50
Authors: Nelson Dylan , Sharma Prateek , Pillepich Annalisa , Springel Volker , Pakmor Rüdiger , Weinberger Rainer , Vogelsberger Mark , Marinacci Federico , Hernquist Lars 
Published: August 2020

ABSTRACT
We use the high-resolution TNG50 cosmological magnetohydrodynamical simulation to explore the properties and origin of cold circumgalactic medium (CGM) gas around massive galaxies (M⋆ &gt; 1011 M⊙ ) at intermediate redshift ($z \sim 0.5$). We discover a significant abundance of small-scale, cold gas structure in the CGM of ‘red and dead’ elliptical systems, as traced by neutral H i and Mg ii. Halos can host tens of thousands of discrete absorbing cloudlets, with sizes of order a kpc or smaller. With a Lagrangian tracer analysis, we show that cold clouds form due to strong $\delta \rho / \bar{\rho } \gg 1$ gas density perturbations that stimulate thermal instability. These local overdensities trigger rapid cooling from the hot virialized background medium at ∼107 K to radiatively inefficient ∼104 K clouds, which act as cosmologically long-lived, ‘stimulated cooling’ seeds in a regime where the global halo does not satisfy the classic tcool/tff &lt; 10 criterion. Furthermore, these small clouds are dominated by magnetic rather than thermal pressure, with plasma β ≪ 1, suggesting that magnetic fields may play an important role. The number and total mass of cold clouds both increase with resolution, and the mgas ≃ 8 × 104 M⊙ cell mass of TNG50 enables the ∼ few hundred pc, small-scale CGM structure we observe to form. Finally, we make a preliminary comparison against observations from the COS-LRG, LRG-RDR, COS-Halos, and SDSS LRG surveys. We broadly find that our recent, high-resolution cosmological simulations produce sufficiently high covering fractions of extended, cold gas as observed to surround massive galaxies.
A systematic ageing method I: H ii regions D118 and D119 in NGC 300
Authors: Stevance H F , Eldridge J J , McLeod A , Stanway E R , Chrimes A A 
Published: August 2020

ABSTRACT
Accurately determining the age of H ii regions and the stars they host is as important as it is challenging. Historically, the most popular method has been isochrone fitting to Hertzsprung–Russell diagrams or colour–magnitude diagrams. Here, we introduce a different method for age determination using BPASS (Binary Population and Spectral Synthesis) and hoki . We infer the most likely ages of the regions D118 and D119 NGC 300 to be log(age/yr) = $6.86^{+0.05}_{-0.06}$ and we also deduce stellar mass and number counts by comparison with the BPASS models. We compare how our binary and single-star models perform and find that the latter are unable to predict 20 per cent (±10 per cent) of our sample. We also discuss how results obtained from isochrone fitting would differ. We conclude that ages could be underestimated by ∼0.2 dex and that the limitations of the isochrone method is not solely due to the lack of binary stars. We propose that the method presented here is more reliable and more widely applicable since it can be used on smaller samples. Alongside this study, we release new hoki features to allow easy implementation of this method.