bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT features and artificial intelligence quantitative analysis of recovered COVID-19 patients with negative RT-PCR and clinical symptoms
Authors: Du Siyao , Gao Si , Huang Guoliang , Li Shu , Chong Wei , Jia Ziyi , Hou Gang , Zhang Lina 
Published: April 2020

Abstract
Objectives: To evaluate imaging features and performed quantitative analysis for mild novel coronavirus pneumonia (COVID-19) cases ready for discharge.Methods: CT images of 125 patients (16-67 years, 63 males) recovering from COVID-19 were examined. We defined the double-negative period (DNp) as the period between the sampling days of two consecutive negative RT-PCR and three days thereafter. Lesion demonstrations and distributions on CT in DNp (CTDN) were evaluated by radiologists and artificial intelligence (AI) software. Major lesion transformations and the involvement range for patients with follow-up CT were analyzed.Results: Twenty (16.0%) patients exhibited normal CTDN; abnormal CTDN for 105 indicated ground-glass opacity (GGO) (99/125, 79.2%) and fibrosis (56/125, 44.8%) as the most frequent CT findings. Bilateral-lung involvement with mixed or random distribution was most common for GGO on CTDN. Fibrous lesions often affected both lungs, tending to distribute on the subpleura. Follow-up CT showed lesion improvement manifesting as GGO thinning (40/40, 100%), fibrosis reduction (17/26, 65.4%), and consolidation fading (9/11, 81.8%), with or without range reduction. AI analysis showed the highest proportions for right lower lobe involvement (volume, 12.01±35.87cm3; percentage; 1.45±4.58%) and CT-value ranging –570 to –470 HU (volume, 2.93±7.04cm3; percentage, 5.28±6.47%). Among cases with follow-up CT, most of lung lobes and CT-value ranges displayed a significant reduction after DNp.Conclusions: The main CT imaging manifestations were GGO and fibrosis in DNp, which weakened with or without volume reduction. AI analysis results were consistent with imaging features and changes, possibly serving as an objective indicator for disease monitoring and discharge.
Uji Antifungi Susu Fermentasi Komersial pada Candida non-albicans
Authors: Khikmah Nur , Sulistyani Nunung 
Published: April 2020

Bakteri Asam Laktat (BAL) yang terkandung dalam susu fermentasi akan menghasilkan asam-asam organik, hidrogen peroksida, diasetil, asetaldehid, asetoin, reutinin, reuterisiklin dan bakteriosin, dapat sebagai anti-Candida. Spesies Candida non-albicans seperti C. tropicalis dan C. glabrata sebagai penyebab kandidiasis oral cenderung meningkat. Tujuan penelitian ini mengetahui aktivitas antifungi susu fermentasi komersial pada Candida non-albicans dan viabilitas bakteri asam laktat di dalam susu fermentasi komersial. Aktivitas antifungi pada Candida non-albicans dilakukan dengan metode difusi sumuran. Viabilitas bakteri asam laktat dihitung berdasarkan jumlah bakteri asam laktat sebagai jumlah bakteri total (Total Plate Count). Hasil penelitian menunjukkan bahwa susu fermentasi komersial lebih mampu menghambat C. tropicalis dibandingkan C. glabrata. Viabilitas bakteri asam laktat dalam susu fermentasi komersial 107-1010 CFU/mL.
Lactic Acid Bacteria (LAB) contained in fermented milk will produce organic acids, hydrogen peroxide, diacetyl, acetaldehyde, acetoin, reutinin, reuterycline and bacteriocin, as anti-Candida. Candida non-albicans species such as C. tropicalis and C. glabrata as causes of oral candidiasis tend to increase. The aim of this research was to determine the antifungal activity of commercial fermented milk against Candida non-albicans and viability of lactic acid bacteria in commercial ermented milk. The antifungal activity was determined using well diffusion method. Viability of lactic acid bacteria is calculated as Total Plate Count. The results showed that commercial fermented milk was more able to inhibit C. tropicalis compared C. glabrata. Viability of lactic acid bacteria 107-1010 CFU/mL.
Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates
Authors: García-Borjas Karla Alejandra , Ceballos-Olvera Ivonne , Luna-Castro Sarahí , Peña-Avelino Yosahandy 
Published: April 2020

Background:
Bovine Lactoferrin (bLf) has been reported as antimicrobial, antiviral,
immunomodulatory and anticancer protein. Escherichia coli and Listeria spp. are food-borne bacteria
that can produce illness in human being and mammals, the emergent antimicrobial drug resistance
has been reported in these pathogens.

Objective:
The aim for this study was to evaluate the bLf effect on in vitro biofilm production and
the synergic effect of antibiotics on E. coli and Listeria isolates.

Methods:
E. coli and Listeria specimens were isolated from bovine carcasses and slaughterhouses
surfaces, respectively. Biofilm formation was analyzed with or without bLf, incubated for 48 h and
spectrophotometry, cell viability was analyzed by colony-forming unit (CFU) and the synergistic
effect of bLf with ampicillin, oxytetracycline, and streptomycin was evaluated through the fractional
concentration index (FCI).

Results:
Our results show that a low bLf concentration (0.8 μM) can diminish the in vitro biofilm
production in Listeria isolates; also improves the in vitro oxytetracycline and streptomycin activity
against E. coli, and ampicillin activity against Listeria isolates.

Conclusion:
bLf can affect the biofilm production in Listeria isolates from slaughterhouses surfaces
and shown synergic effect with ampicillin. Also has a synergic effect with oxytetracycline
and streptomycin against E. coli isolates from bovine carcasses.
Nanoparticles for Sustainable Agriculture and their Effect on Plants
Authors: Srivastava Amrisha , Singh Rachana 
Published: April 2020

Abstract:
Nano-biotechnology is gaing attention in the field of agriculture because of its different
applications such as release of nutrients, pesticides, nanosensors, veterinary care, detection of nutrient
deficiencies and many more. Nanoparticles, measured in nano size, is used in variety of forms to
improve the efficiency of nutrient utilization and reduces the costs of environmental protection. Nano
fertilizer, one of the important aspect of nanoparticles. It facilitates incorporation of measured
amount of nutrition to the crops which reduces the chance of nutrition loss, thus helps to improve
crop fertility. Toxic waste from soil and water can also be reduced by the use of different agrichemicals.
Nanotechnology has the potential to detect the disease at an early stage and also improves the
ability of plants to uptake nutrients, thus improving agriculture and food industry. This review covers
the use of different nanoparticles in agriculture as plant growth promoters and their use in controlling
plant diseases.
Electrospun Biodegradable Bi-Layered Microfiber Membranes for Aluminum Removal from Drinking Water
Authors: Sultana Naznin 
Published: April 2020

Aims:
This study aimed to eliminate metallic contaminants from drinking water by using
electrospun bi-layered microfiber membranes.

Background:
Fast industrialization triggers environmental pollution. Heavy metals like silver, lead
and aluminum are the major contaminants that are extremely toxic and accumulate in biological tissues
through the food chain and cause a health hazard. Electrospinning is a promising technique
among other conventional techniques of removing these metals from drinking water. Electrospun
membranes possess suitable properties for microfiltration purposes. In this study, to fabricate electrospun
membranes, polycaprolactone (PCL) and zeolites were used as materials. PCL polymer is biocompatible
and biodegradable, and zeolite is microporous, which is good for filtration or molecular
sieving application.

Methods:
Using the electrospinning technique, PCL, PCL/zeolite, PCL and PCL/zeolite bi-layered
electrospun membranes were fabricated. The properties of the membranes were evaluated using different
techniques. The performance of the membranes was tested by filtering Aluminum (Al) present
in drinking water.

Results:
Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analyses confirmed
the removal of Al using the membranes. ICP-OES results showed above 90% of Al removal
using PCL and PCL/zeolite electrospun membrane.

Conclusion:
These membranes are non-toxic and biodegradable and have the potential to be used for
microfiltration purposes.
ЗАСТОСУВАННЯ МЕТОДУ «ПРОФЕСІЙНО-ПРАКТИЧНОЇ ЗДОРОВОЇ КОНКУРЕНЦІЇ» СЕРЕД СТУДЕНТІВ МЕДИЧНИХ ВУЗІВ.
Authors: Готюр О. І. 
Published: April 2020

Резюме. На протязі 5-ти років мною були проведені спостереження за навчанням та успішністю студентів і зроблені відповідні висновки на основі яких я склала та пропоную до застосування метод під назвою – «Професійно-практичної здорової конкуренції» для контролю рівня практичної підготовки та стимуляції до індивідуального навчання студентів.
Мета: швидко та якісно допомогти студентам професійно оволодіти практичними навиками на муляжах у практично-тренінгових центрах.
Матеріали та методи. Я спостерігала за тими студентами які здавали зрізи практичних навиків у стандартному – демонстраційному режимі відтворення вивчених практичних навиків, це 126 студентів які увійшли у групу – Б (стандарт) та окремо – за 128 студентами які здавали зрізи практичних навиків за методикою – «Професійно-практичної здорової конкуренції» і увійшли у групу-А у кожному році відповідно.
Результати дослідження. Провівши аналіз результатів оцінювання зрізів практичних навиків, ми бачимо, що кількість «відмінних» оцінок значно більша у групах-А в порівнянні із групами-Б (стандарт) на різних роках спостереження.
Студенти групи-Б (стандарт) продемонстрували низьку підготовку до демонстрації практичних навиків набравши у результаті двох основних зрізів практичних навиків високий відсоток «задовільних» та - «незадовільних» оцінок.
Висновки:
Методика «Професійно-практичної здорової конкуренції» у здачі практичних навиків показала позитивні результати у стимуляції студентів до індивідуальної підготовки до контролю здачі зрізів практичних навиків на ІІ курсі студентами медичного коледжу при Івано-Франківському Національному Медичному Університеті.
User Experience and Potential Health Effects of a Conversational Agent-Based Electronic Health Intervention: Protocol for an Observational Cohort Study
Authors: Hurmuz Marian Z M , Jansen-Kosterink Stephanie M , op den Akker Harm , Hermens Hermie J 
Published: April 2020

Background
While the average human life expectancy has increased remarkably, the length of life with chronic conditions has also increased. To limit the occurrence of chronic conditions and comorbidities, it is important to adopt a healthy lifestyle. Within the European project “Council of Coaches,” a personalized coaching platform was developed that supports developing and maintaining a healthy lifestyle.

Objective
The primary aim of this study is to assess the user experience with and the use and potential health effects of a fully working Council of Coaches system implemented in a real-world setting among the target population, specifically older adults or adults with type 2 diabetes mellitus or chronic pain.

Methods
An observational cohort study with a pretest-posttest design will be conducted. The study population will be a dynamic cohort consisting of older adults, aged ≥55 years, as well as adults aged ≥18 years with type 2 diabetes mellitus or chronic pain. Each participant will interact in a fully automated manner with Council of Coaches for 5 to 9 weeks. The primary outcomes are user experience, use of the program, and potential effects (health-related factors). Secondary outcomes include demographics, applicability of the virtual coaches, and user interaction with the virtual coaches.

Results
Recruitment started in December 2019 and is conducted through mass mailing, snowball sampling, and advertisements in newspapers and social media. This study is expected to conclude in August 2020.

Conclusions
The results of this study will either confirm or reject the hypothesis that a group of virtual embodied conversational coaches can keep users engaged over several weeks of interaction and contribute to positive health outcomes.

Trial Registration
The Netherlands Trial Register: NL7911; https://www.trialregister.nl/trial/7911

International Registered Report Identifier (IRRID)
PRR1-10.2196/16641
Diabetes Management Experience and the State of Hypoglycemia: National Online Survey Study
Authors: Zahed Karim , Sasangohar Farzan , Mehta Ranjana , Erraguntla Madhav , Qaraqe Khalid 
Published: April 2020

Background
Hypoglycemia, or low blood sugar levels, in people with diabetes can be a serious life-threatening condition, and serious outcomes can be avoided if low levels of blood sugar are proactively detected. Although technologies exist to detect the onset of hypoglycemia, they are invasive or costly or exhibit a high incidence of false alarms. Tremors are commonly reported symptoms of hypoglycemia and may be used to detect hypoglycemic events, yet their onset is not well researched or understood.

Objective
This study aimed to understand diabetic patients’ perceptions of hypoglycemic tremors, as well as their user experiences with technology to manage diabetes, and expectations from a self-management tool to ultimately inform the design of a noninvasive and cost-effective technology that detects tremors associated with hypoglycemia.

Methods
A cross-sectional internet panel survey was administered to adult patients with type 1 diabetes using the Qualtrics platform in May 2019. The questions focused on 3 main constructs: (1) perceived experiences of hypoglycemia, (2) experiences and expectations about a diabetes management device and mobile app, and (3) beliefs and attitudes regarding intention to use a diabetes management device. The analysis in this paper focuses on the first two constructs. Nonparametric tests were used to analyze the Likert scale data, with a Mann-Whitney U test, Kruskal-Wallis test, and Games-Howell post hoc test as applicable, for subgroup comparisons to highlight differences in perceived frequency, severity, and noticeability of hypoglycemic tremors across age, gender, years living with diabetes, and physical activity.

Results
Data from 212 respondents (129 [60.8%] females) revealed statistically significant differences in perceived noticeability of tremors by gender, whereby males noticed their tremors more (P<.001), and age, with the older population reporting lower noticeability than the young and middle age groups (P<.001). Individuals living longer with diabetes noticed their tremors significantly less than those with diabetes for ≤1 year but not in terms of frequency or severity. Additionally, the majority of our participants (150/212, 70.7%) reported experience with diabetes-monitoring devices.

Conclusions
Our findings support the need for cost-efficient and noninvasive continuous monitoring technologies. Although hypoglycemic tremors were perceived to occur frequently, such tremors were not found to be severe compared with other symptoms such as sweating, which was the highest rated symptom in our study. Using a combination of tremor and galvanic skin response sensors may show promise in detecting the onset of hypoglycemic events.
The Temporal Structure of Patience
Authors: Kelly Michael R. 
Published: April 2020

Abstract
This paper presents Anthony Steinbock's broad theory of moral emotions and specifically the distinction he draws between the temporal orientation and the temporal meaning of emotions. The latter distinction is used in order to provide phenomenological descriptions of, and distinctions between, patience and impatience. The paper takes leading clues from Steinbock’s work in an effort to “do” phenomenology in a way that clarifies these specific natural attitude intentionalities.
Augmented reality: Analisis Pengembangan Media Pembelajaran Kimia untuk Meningkatkan Keterampilan 4C Mahasiswa
Authors: Elisa Edi , Wiratmaja IGede 
Published: April 2020

[ Augmented reality: Analysis of Development the Chemical Instructional Media to Improve 4c Skill of Students ]
Penelitian ini bertujuan untuk mengetahui proses pengembangan media pembelajaran kimia berbasis augmented reality dengan harapan dapat digunakan untuk meningkat keterampilan 4C mahasiswa. Jenis penelitian termasuk kedalam penelitian dan pengembangan (R&D) dengan menggunakan model pengembangan ADDIE yang terdiri dari lima tahap. Pada artikel ini pembahasan akan difokuskan pada tahap analisis. Fokus kegiatan pada tahap analisis yaitu menganalisa keterampilan yang dibutuhkan di abad 21, menganalisa proses pembelajaran, menganalisa berbagai kemungkinan media pembelajaran yang dapat digunakan dan mengambil suatu keputusan. Instrumen yang digunakan pada tahap ini yaitu lembar observasi, tes essay, angket dan daftar pertanyaan wawancara. Subjek uji coba adalah program studi Pendidikan Teknik Mesin Fakultas Teknik dan Kejuruan Universitas Pendidikan Ganesha, sampel merupakan mahasiswa yang mengontrak matakuliah kimia teknik. Berdasarkan hasil analisis kebutuhan dan analisis awal dan akhir, maka ditetapkan media yang paling sesuai dan akan dikembangkan yaitu augmented reality yang didukung dengan seperangkat kartu pembelajaran. Produk yang dihasilkan harus didesain untuk dapat meningkatkan keterampilan 4C mahasiswa.
Adapted Three-step Restorative Technique: Recovering Dental Substrate Compromised by Complex Erosive Wear in a Young Patient
Authors: Villavicencio-Espinoza CA , Giacomini MC , Narimatsu MH , Magalhães AC , Atta MT , Wang L 
Published: April 2020

Clinical RelevanceThis article presents the dental restoration of a young female patient complaining of erosive dental wear using a three-step restorative technique, an alternative approach with some novel adjustments.SUMMARYFor successful tooth wear treatment, determining the etiological systemic and local factors is the main priority before deciding on effective and long-term preventive and/or therapeutic restorative approaches. In addition to professional intervention, achieving optimal outcomes requires patients to control their diet and/or gastric issues, thus minimizing the wear process. However, continuous wear constitutes the most challenging scenario, mainly when it affects young patients’ dentitions. This article describes the dental restoration of posterior teeth with reestablishment of occlusal vertical dimension before treating the anterior teeth, while educating the patient and providing medical monitoring. The three-step restorative technique seems to be properly applicable in cases of significant dental compromise due mainly to erosive wear and is based on direct procedures, which can assure a reliable and feasible approach.
Influence of Bulk-fill Restoration on Polymerization Shrinkage Stress and Marginal Gap Formation in Class V Restorations
Authors: Correia AMO , Andrade MR , Tribst JPM , Borges ALS , Caneppele TMF 
Published: April 2020

Clinical Relevance
Restoring Class V cavities with a regular bulk-fill composite presents a more favorable biomechanical behavior than restoring with a regular nano-filled composite.

SUMMARY

Purpose:
This study evaluated the influence of Class V cavity extension and restorative material on the marginal gap formation, before and after aging, and the theoretical polymerization shrinkage stress distribution in a tooth restoration.

Methods and Materials:
Class V cavities with the depth of 2 mm, cervical/incisal distance of 4 mm, and margins located in the enamel 1 mm above the cementoenamel junction were prepared in 60 bovine incisors in two mesiodistal dimensions (n=30): 2.9-mm large extension cavities (LE) or 1.4-mm small extension cavities (SE). The cavities' depths were validated using a periodontal probe, while the mesiodistal and cervical/incisal distances were measured using a stereomicroscope. After adhesive application (Clearfil SE Bond), each group was randomly divided into two groups (n=15) according to the restorative material: Filtek Z350 XT (N) or Filtek Bulk Fill Posterior (BF). The marginal gap formation between the tooth structure and the restorative material was evaluated using a stereomicroscope before and after thermocycling for 15,000 cycles (5°C and 55°C). Data were analyzed using repeated-measures analysis of variance (ANOVA) and Tukey test for multiple comparisons (α=0.05). A three-dimensional geometric model with the same dimensions as the experimental test was created for each cavity, and the restorations were modeled for each restorative material. In the analysis software, the finite element mesh was created with tetrahedral quadratic elements, and the polymerization shrinkage was simulated by thermal analogy. The maximum principal stress was used to express the tensile stress in the adhesive interface through colorimetric graphs.

Results:
For the marginal gap, the repeated-measures ANOVA revealed a significant effect only for the factors composite resin (df=1, F=4.09, p=0.04) and thermal aging (df=1, F=44.35, p&lt;0.001). For all numerical simulations, higher stress concentration occurred at the enamel margin, and the stress peak decreased in the following sequence: LE-N (17.0 MPa) &gt; SE-N (15.0 MPa) &gt; LE-BF (9.1 MPa) &gt; SE-BF (8.2 MPa).

Conclusion:
Marginal gaps in the specimens fell between approximately 12 and 17 μm; however, the regular bulk-fill composite showed less gap formation and better stress distribution around the cavity margin than the regular nano-filled composite, regardless of the cavity extension.
Development of research on the university entrepreneurship ecosystem: trends and areas of interest of researchers based on a systematic review of literature
Authors: Kobylińska Urszula , Lavios Juan J. 
Published: April 2020

Research background: The concept of the university entrepreneurship ecosystem is nowadays a part of the current trends in researching the determinants of support for commercialization of research results. The subject is relatively new, because the first papers in this topic are dated to 2009, and in fact it has only been in the last 3 years that the interest of researchers in this subject has increased.
Purpose of the article: The purpose of this study is to analyze the state of research on the issue of the university ecosystem of academic entrepreneurship and to identify the main research trends related to this topic.
Methods: The article was based on a systematic review of the literature (SLR), which included the selection of basic literature and selection of publications, mayor researchers, bibliometric analysis and content analysis.
Findings & Value added: The results of the conducted research indicate that the study of the university ecosystem of academic entrepreneurship is still a new issue, poorly recognized in literature, without a solid methodological foundation and which may constitute a current and interesting research area. Our paper adds to existing research in four important ways. We provide a holistic review of university entrepreneurial ecosystem. We also identify the challenges identified in this area and suggest how they may be developed. Third, our results are also policy-relevant. For policy-makers, it is important to know whether academic engagement is driven by mechanisms existing in academic ecosystem or affected by factors that may not be activated by it.