bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of p53, HIF1a, Ki-67, CA-9, and GLUT1 Expression on Treatment Outcomes in Locally Advanced Cervical Cancer Patients Treated With Definitive Chemoradiation Therapy
Authors: Gaber Germaine , El Achy Samar , Khedr Gehan A. , Parimi Vamsi , Helenowksi Irene , Donnelly Eric D. , Strauss Jonathan B. , Woloschak Gayle , Wei Jian-Jun , Small William , Refaat Tamer 
Published: December 2020

Purpose/Objective:
The objective of this study was to assess the association between pretreatment p53, hypoxia inducible factor 1a (HIF1a), Ki-67, carbonic anhydrase-9 (CA-9), and glucose transporter 1 (GLUT1) expression in locally advanced cervical cancer patients treated definitively with concurrent chemoradiation therapy (CRT) and treatment outcomes including overall survival (OS), progression-free survival (PFS), local-regional control (LC), and distant metastases–free survival (DMFS).

Patients and Methods:
Twenty-eight patients treated definitively and consecutively for cervical cancer with CRT had p53, HIF1a, Ki-67, CA-9, and GLUT1 protein expression assessed and scored semiquantitatively by 3 pathologists, blinded to the treatment outcomes. Outcomes were stratified by p53 (H-score: <15 vs. ≥15), HIF1a (H-score: <95 vs. ≥95), Ki-67 (labeling index <41% vs. ≥41%), CA-9 (H-score: <15 vs. ≥15), and GLUT1 (H-score: <175 vs. ≥175) expression. OS, PFS, LC, and DMFS rates were calculated using the Kaplan-Meier method, and differences between groups were evaluated by the log-rank test.

Results:
Notable clinical characteristics of the cohort included median age of 51 years (range: 32 to 74 y), FIGO stage IIB disease (57.2%), clinical node-negative disease (64.3%), squamous cell carcinoma (89.3%), and adenocarcinoma (10.7%). Treatment outcomes included 5-year OS (57.2%), PFS (48.1%), LC (72.1%), and DMFS (62.9%). For HIF1a H-score <95 and ≥95, the 5-year OS (52.0% and 68.4%, P=0.58), PFS (53.0% and 40.9%, P=0.75), LC (71.6% and 68.2%, P=0.92), and DMFS (59.7% and 52.0%, P=0.91) were not significantly different. For Ki-67 labeling index <41% and ≥41%, the 5-year OS (44.9% and 66.6%, P=0.35), PFS (38.9% and 55.4%, P=0.53), LC (57.7% and 85.7%, P=0.22), and DMFS (67.3% and 61.0%, P=0.94) were not significantly different. For CA-9 H-score <15 and ≥15, the 5-year OS (54.4% and 66.7%, P=0.39), PFS (57.3% and 40.0%, P=0.87), LC (70.0% and 70.0%, P=0.95), and DMFS (70.0% and 46.7%, P=0.94) were not significantly different. For GLUT1 H-score <175 and ≥175, the 5-year OS (43.6% and 43.6%, P=0.32), PFS (55.6% and 49.5%, P=0.72), LC (72.9% and 71.5%, P=0.97), and DMFS (62.5% and 59.6%, P=0.76) were not significantly different. For p53, H-score <15 and ≥15, the 5-year OS (62% and 53%), PFS (63% and 30.3%), LC (87.5% and 52%), and DMFS (79.6% and 41.6%).

Conclusions:
In this study population, HIF1a, Ki-67, CA-9, and GLUT1 expression did not predict treatment response or outcomes in locally advanced cervical cancer patients treated definitively with CRT. There was a nonstatistically significant trend towards worse outcomes with p53 expression.
Optimizing Care for Patients With Adverse Events From Immunotherapeutics
Authors: Sheehan Kelsey , Price Christina , Hafez Navid 
Published: December 2020

Abstract
Immune-related adverse events (irAEs) are a common occurrence in patients treated with immune checkpoint inhibitors. Fortunately, the majority of irAEs are mild and easily managed with steroids. As the use of immune checkpoint inhibitors and other immune therapies continues to increase across indications, so too will the need for managing irAEs. Optimal care for irAEs should include surveillance and early detection, guideline-driven management of standard irAEs, multidisciplinary expert involvement in complicated or steroid-refractory cases, and concurrent research to define predictive biomarkers and delineate the populations, which can be safely treated and retreated with immune therapies. In this article, we describe the implementation of a 3-pronged strategy used at our institution consisting of an Immune Wellness Clinic to risk stratify and monitor at-risk patients, an Immuno-Oncology Treatment Monitoring Repository to support translational research, and an Immunotoxicity Tumor Board to manage severe or complicated adverse events.
Moving Immunotherapy Into Early-Stage Lung Cancer
Authors: Linehan Anna , Forde Patrick M. 
Published: December 2020

Abstract
Blockade of the programmed cell death 1 immune inhibitory pathway has revolutionized the treatment of advanced non–small cell lung cancer and led to significant improvements in overall survival. In contrast, early-stage surgically resectable lung cancer has had few treatment advances in many years and continues to be associated with a high risk of relapse despite apparent curative resection. In this review, we discuss the many ongoing efforts to incorporate programmed cell death 1 pathway blockade into the treatment paradigm for surgically resectable lung cancer both as adjuvant and neoadjuvant therapy. We review the early-phase results from neoadjuvant clinical trials, the landscape of phase III trials that are ongoing, and look to the future of immune checkpoint blockade as a potential curative therapy for surgically resectable lung cancer.
NIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research
Authors: Pahwa Savita , Deeks Steven , Zou Shimian , Tomitch Natalie , Miller-Novak Leia , Caler Elisabet , Justice Amy , Sacktor Ned , Gabuzda Dana , Hunt Peter W. , Brown Todd , Kurth Ann , Baral Stefan , Mugavero Michael , Mayer Kenneth H. , Mendenhall Emily , Detels Roger , Mutabazi Vincent 
Published: December 2020

Background:With potent antiretroviral therapy and simplified regimens, people living with HIV (PWH) are achieving near-normal lifespans but not necessarily a normal health span or healthy aging. PWH have a higher than expected risk of developing a number of non-AIDS comorbidities, coinfections, and complications (CCC), often against a background of stigma, poverty, and isolation.Setting:To gain a better understanding of research needs for HIV-associated CCC, the NIH convened a 2-day workshop (HIV-associated CCC, or HIV ACTION).Methods:A cross-institute NIH planning committee identified 6 key research areas: epidemiology and population research, pathogenesis and basic science research, clinical research, implementation science research, syndemics research and international research in low and middle income countries. Investigators were selected to lead working groups (WGs) to assess the state-of-the-art and identify 3–5 priority areas in each field before the workshop. A 2-day program at the NIH was developed which included presentations by invited experts and WG members.Results:Over 400 participants attended the workshop. After general and individual WG discussions, the most pressing gaps, questions, or proposed action items were identified. Priority lists of pressing research issues were presented by cochairs of each WG. A detailed report is posted at the NHLBI website. This article reports the streamlined priority list and a summary of WG discussions to inform investigators of current priorities in the field.Conclusion:Collaborative efforts of many disciplines are needed to improve the health and wellbeing of PWH. Several common themes emerged across WG representing potential priorities for investigators and recommendations for the NIH.
Bottom-up fabrication of a multi-component nanopore sensor that unfolds, processes and recognizes single proteins
Authors: Zhang Shengli , Huang Gang , Versloot Roderick , Herwig Bart Marlon , de Souza Paulo Cesar Telles , Marrink Siewert-Jan , Maglia Giovanni 
Published: December 2020

AbstractTransmembrane channels and pores have many biotechnological applications, notably in the single-molecule sequencing of DNA. Small synthetic nanopores have been designed using amphipathic peptides, or by assembling computationally designed transmembrane helices. The fabrication of more complex transmembrane devices has yet to be reported. In this work, we fabricated in two steps a multi-protein transmembrane device that addresses some of the main challenges in nanopore protein sequencing. In the first step, artificial nanopores are created from soluble proteins with toroid shapes. This design principle will allow fabricating a variety of nanopores for single-molecule analysis. In the second step one α-subuinit of the 20S proteasome fromThermoplasma acidophilumis genetically integrated into the artificial nanopore, and a 28-component nanopore-proteasome is co-assembled inE. colicells. This multi-component molecular machine opens the door to two new approaches in protein sequencing, in which selected substrate proteins are unfolded, fed to into the proteasomal chamber and then identified by the nanopore sensor either as intact or fragmented polypeptides. The ability to integrate molecular devices directly onto a nanopore sensors allows creating next-generation protein sequencing devices, and will shed new lights on the fundamental processes of biological nanomachines.
Integrated analytical hierarchy process and grey relational analysis approach to measure supply chain complexity
Authors: Piya Sujan , Shamsuzzoha Ahm , Khadem Mohammed , Al Kindi Mahmoud 
Published: December 2020

PurposeThe purpose of this paper is to understand the drivers that create complexity in the supply chain and develop a mathematical model to measure the level of supply chain complexity (SCC).Design/methodology/approachThrough extensive literature review, the authors discussed various drivers of SCC. These drivers were classified into five dimensions based on expert opinion. Moreover, a novel hybrid mathematical model was developed by integrating analytical hierarchy process (AHP) and grey relational analysis (GRA) methods to measure the level of SCC. A case study was conducted to demonstrate the applicability of the developed model and analyze the SCC level of the company in the study.FindingsThe authors identified 22 drivers of SCC, which were further clustered into five complexity dimensions. The application of the developed model to the company in the case study showed that the SCC level of the company was 0.44, signifying that there was a considerable scope of improvement in terms of minimizing complexity. The company that serves as the focus of this case study mainly needs improvement in tackling issues concerning government regulation, internal communication and information sharing and company culture.Originality/valueIn this paper, the authors propose a model by integrating AHP and GRA methods that can measure the SCC level based on various complexity drivers. The combination of such methods, considering their ability to convert the inheritance and interdependence of drivers into a single mathematical model, is preferred over other techniques. To the best of the authors' knowledge, this is the first attempt at developing a hybrid multicriteria decision-based model to quantify SCC.
“We care about others”: discursive constructions of corruption vis-à-vis national/cultural identity in Indonesia’s business-government relations
Authors: Pertiwi Kanti 
Published: December 2020

Purpose
This paper aims to problematize existing conceptualization of corruption by presenting alternative perspectives on corruption in Indonesia through the lens of national/cultural identity, amidst claims of the pervasiveness of corruption in the country. In so doing, the paper also sheds light on the micro-processes of interactions between global and local discourses in postcolonial settings.

Design/methodology/approach
The study applies discourse analysis, involving in-depth interviews with 40 informants from the business sector, government institutions and anti-corruption agencies.

Findings
The findings suggest that corruption helps government function, preserves livelihoods of the marginalized segments of societies and maintains social obligations/relations. These alternative meanings of corruption persist despite often seen as less legitimate due to effects of colonial powers.

Research limitations/implications
The snowballing method of recruiting informants is one of the limitations of this paper, which may decrease the potential diversity and lead to the silencing of different stories (Schwartz-Shea and Yanow, 2013). Researchers need to contextualize corruption and study its varied meanings to reveal its social, historical and political dimensions.

Practical implications
This paper strongly suggests that we need to move beyond rationalist accounts to capture the varied meanings of corruption which may be useful to explain the limited results of existing anti-corruption efforts.

Social implications
This study calls for a greater use of qualitative methods to study broad social change programs such as anti-corruption from the perspective of the insiders.

Originality/value
This paper contributes to the discussion of agency at the interplay between the dominant and alternative discourses in postcolonial settings. Moreover, the alternative meanings of corruption embedded in constructions of national identity and care ethics discussed in this paper offer as a starting point for decolonizing (Westwood, 2006) anti-corruption theory and practice.
Determinants of CSRD in non-Asian and Asian countries: a literature review
Authors: Abdullah Yasir , Ahmad-Zaluki Nurwati A. , Rahim Nazahah Abd 
Published: December 2020

Purpose
The purpose of this paper is to review the current status of research works on corporate social responsibility disclosure (CSRD) in both non-Asian and Asian countries. It seeks to provide an overview of existing literatures to facilitate future research.

Design/methodology/approach
The present study used the content analysis of 64 empirical research papers from 41 countries from 1990 to 2020 to show the rapid development of and global focus on CSRD. Various CSRD measures had been used in previous researches on the extent and quality of disclosure.

Findings
Company characteristics, namely, company size, age, profitability, industry, share price performance and corporate governance mechanisms and their impact on CSRD, were investigated. Crucial variances between the determinants of CSRD in non-Asian and Asian countries were also reviewed. In non-Asian countries, especially the advanced ones, specific stakeholders such as regulators, the environment, shareholders, ownership and media are considered very significant in the disclosure of CSR information. Meanwhile, in Asian countries, CSRD is more affected by external strength and stakeholders, which include international capital markets, creditors, the environment, international media and ownership.

Research limitations/implications
The determinants of CSRD, namely, community, workplace, environment and marketplace issues received very little pressure from the public. This paper suggests that there is a need for more studies examining CSRD in non-Asian and Asian (emerging) countries.

Social implications
Business organisations in non-Asian and Asian countries should take social practices into consideration in their CSRD decision-making. This review highlights the significance of merging organisational and social activities.

Originality/value
This study adds value by examining CSRD aspects that were not reviewed in previous studies on CSRD in non-Asian and Asian countries. This study provides a comprehensive review of the determinants of CSRD in both non-Asian and Asian countries.
Exploring halal tourism in Muslim-minority countries: Muslim travellers’ needs and concerns
Authors: Said Mohd Fuaad , Adham Khairul Akmaliah , Muhamad Nur Sa’adah , Sulaiman Syahnaz 
Published: December 2020

Purpose
This study focusses on the underlying needs of Muslims to adhere to the tenets of their religion and to guide their behaviours accordingly. These requirements, for the purpose of travelling, constitute halal tourism. As Muslim-minority nations, such as Taiwan, South Korea and Japan, began to market their own brands of halal tourism, there are concerns of whether their current practices are able to meet the requirements of Muslim travellers. Thus, this study aims to understand the main needs and concerns of Muslim travellers when they visit Muslim-minority countries.

Design/methodology/approach
Interviews were conducted on selected Muslim travellers who recently visited one of the following destinations, Japan, South Korea or Taiwan. Applying the process theory of travel, service marketing perspective and Muslim religious needs, the study’s conceptual framework served as the basis for crafting interview questions, selecting the participants and explaining the findings.

Findings
Muslim travellers are mostly concerned with the need to perform daily prayers and to find halal food at the point of need, and willing to conduct extensive research on the destination prior to their visit. Muslim travellers’ experiences in these Muslim-minority countries are generally met with their expectations, although further socialisation with the locals is needed to induce greater overall satisfaction with the destinations.

Practical implications
Understanding the current practices of halal tourism is critical so that improvements can be implemented in the industry.

Originality/value
Key preparations, expectations, actual experiences in the destinations and reflections of Muslim travellers provide in-depth insights into their needs and concerns when travelling in Muslim-minority countries. The emergent religion-based dimensions in service experience, such as availability of social agents and halal food at the point of need, extend the conceptualisation of perishability and heterogeneity in service marketing literature.
Retooling our anti-corruption arsenals: exploring the potential use of CAQDAS in corruption investigation
Authors: Prabowo Hendi Yogi 
Published: December 2020

Purpose
This paper aims to explore the potential of computer-assisted qualitative data analysis software (CAQDAS) to be used as a corruption investigation tool to help investigators in carrying out their investigative works.

Design/methodology/approach
By reviewing the literature on qualitative research and fraud investigation, this exploratory study identifies similarities between the two types of inquiries and thus proposing the use of CAQDAS as an innovation in the field of corruption investigation. To demonstrate how a QDA application can support corruption investigators, NVivo is used as a case study from which various key analytical tools are discussed to highlight their potential in supporting a corruption investigation.

Findings
As a fundamental part of anti-corruption practice in a country, corruption investigation must be planned and executed professionally and adequately. This paper highlights various stages in fraud investigation to identify areas that can be improved with the use of a CAQDAS. Based on the discussion in this paper, the author concludes that the capability of a CAQDAS to assist users in data reduction and data display has the potential to increase the effectiveness and efficiency in various stages of a corruption investigation.

Research limitations/implications
Based on a self-funded study, this paper only uses a simulation case with a fictitious company to illustrate how a CAQDAS application can be used to support a corruption investigation process. Future studies may benefit from using actual corruption cases in illustrating how such an application can support the investigation process.

Practical implications
This paper contributes to the innovation in anti-corruption practice by proposing a new framework and tool to develop corruption investigation capacity.

Originality/value
This paper brings a new perspective into the field of anti-corruption to stimulate innovation in the area of corruption investigation.
Beliefs, knowledge and finite provinces of meaning: the case for science and the arts
Authors: Jácome de Moura Jr Pedro , Lauritzen Jácome Campos Cecília 
Published: December 2020

Purpose
This paper aims to build around an abductive argument: the epistemological value of the Arts-derived knowledge is equivalent and may be supplementary to that of science, contributing to the literature on the epistemological mistrust between both systems of knowledge.

Design/methodology/approach
This essay proposes a conceptual model – a tool, in Kuhn’s terms – grounded on the sociology of knowledge (Berger and Luckmann, 1967; Schütz, 1951), to frame the apprehension of reality from a social perspective, and the philosophical pragmatism (Peirce, 2012), considering the fixation of beliefs as the seminal concept that leads to the legitimation of knowledge in society. The proposed conceptual model guides analysis on the epistemological value of the knowledge derived from the Arts and supports reflection on the commonalities between both finite provinces of meaning.

Findings
Reproducibility, doxastic grounding, community/membership, intersubjectivity and evidence are criteria identified as commonalities between the Arts and Science. Acceptance and legitimation across finite provinces of meaning emerge to produce minimally acceptable objectivity, made possible by the mutual validation of impressions.

Research limitations/implications
The discussion on greater levels of aesthetic appreciation has been eclipsed by the authors’ intention to find specific epistemological properties of knowledge derived from the Arts.

Practical implications
As practitioners in applied social science, management researchers are supposed to have mastery over how to apply what they know. So, the findings suggest participation (becoming accepted, first of all) in communities of practice, learning from and contributing to distinct finite provinces of meaning. The role of organizations in the understanding of knowledge derived from the Arts and its application might be that of a protagonist, promoting creativity and innovation through openness to new perspectives on knowledge.

Originality/value
This essay rescues knowledge as not a justified true belief, but the result of fixed beliefs continuously and socially legitimated. This rescue escapes previous attempts that appeal to Gettier-type counterexamples. A conceptual model was proposed to frame knowledge from a philosophical and sociological perspective and represent a methodological contribution of this essay. The proposition of third-order interdisciplinarity, also represents a contribution, of conceptual nature.
COVID-19: US shelter-in-place orders and demographic characteristics linked to cases, mortality, and recovery rates
Authors: Alderman Jillian , Harjoto Maretno 
Published: December 2020

Purpose
This study aims to examine the relationship between the duration (in days) of states’ shelter-in-place orders; state demographic characteristics; and the rates of spread (cases), death (mortality), and recovery of COVID-19 in the USA.

Design/methodology/approach
State-level data across 50 states and Washington D.C. from January 23, 2020, to June 11, 2020, and a multivariate regression analysis were used to empirically investigate the impacts of the duration of shelter-in-place orders and state demographic characteristics on the rates of cases, mortality and recovery per capita of COVID-19.

Findings
This study finds that a longer duration of a shelter-in-place order is associated with lower cases and deaths per capita from COVID-19. This study also finds that demographic characteristics, such as the percentage of people who are unsheltered homeless, family size, percentage of individuals with health insurance, income inequality, unemployment rate, gender and race, are related to cases, mortality and recovery rates of COVID-19.

Social implications
This study offers policy implications for state and locality (e.g., city, region and country) lockdown decisions and salient demographics to consider curbing the spread and mortality rate of the COVID-19 pandemic. Study results are important to consider as the world braces for the anticipated resurgence of COVID-19.

Originality/value
This study reveals that the duration of shelter-in-place orders and demographics in states are related to the rates of spread, mortality, and recovery of COVID-19.