bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entomopathogenic nematode-associated microbiota: from monoxenic paradigm to pathobiome
Authors: Ogier Jean-Claude , Pagès Sylvie , Frayssinet Marie , Gaudriault Sophie 
Published: February 2020

Abstract
Background
The holistic view of bacterial symbiosis, incorporating both host and microbial environment, constitutes a major conceptual shift in studies deciphering host-microbe interactions. Interactions between Steinernema entomopathogenic nematodes and their bacterial symbionts, Xenorhabdus, have long been considered monoxenic two partner associations responsible for the killing of the insects and therefore widely used in insect pest biocontrol. We investigated this “monoxenic paradigm” by profiling the microbiota of infective juveniles (IJs), the soil-dwelling form responsible for transmitting Steinernema-Xenorhabdus between insect hosts in the parasitic lifecycle.

Results
Multigenic metabarcoding (16S and rpoB markers) showed that the bacterial community associated with laboratory-reared IJs from Steinernema carpocapsae, S. feltiae, S. glaseri and S. weiseri species consisted of several Proteobacteria. The association with Xenorhabdus was never monoxenic. We showed that the laboratory-reared IJs of S. carpocapsae bore a bacterial community composed of the core symbiont (Xenorhabdus nematophila) together with a frequently associated microbiota (FAM) consisting of about a dozen of Proteobacteria (Pseudomonas, Stenotrophomonas, Alcaligenes, Achromobacter, Pseudochrobactrum, Ochrobactrum, Brevundimonas, Deftia, etc.). We validated this set of bacteria by metabarcoding analysis on freshly sampled IJs from natural conditions. We isolated diverse bacterial taxa, validating the profile of the Steinernema FAM. We explored the functions of the FAM members potentially involved in the parasitic lifecycle of Steinernema. Two species, Pseudomonas protegens and P. chlororaphis, displayed entomopathogenic properties suggestive of a role in Steinernema virulence and membership of the Steinernema pathobiome.

Conclusions
Our study validates a shift from monoxenic paradigm to pathobiome view in the case of the Steinernema ecology. The microbial communities of low complexity associated with EPNs will permit future microbiota manipulation experiments to decipher overall microbiota functioning in the infectious process triggered by EPN in insects and, more generally, in EPN ecology.
Co-creating transdisciplinary global change research agendas in Finland
Authors: Matschoss Kaisa , Pietilä Maria , Rask Mikko , Suni Tanja 
Published: February 2020

AbstractCo-creation principles have become prominent in the scientific disciplines that aim to respond to global sustainability challenges especially in the global south. This paper analyses a co-creation pilot of global change research in the novel context of a Nordic country, Finland. The pilot was organised to learn how to create a future agenda for a complex and transdisciplinary research field of global change. This paper analyses its conceptualisation in Finland, how did the series of engagement events increase the capacities of participants and how did the process contribute to a change towards a new, societally responsible way of co-creating global change research. The study found that co-creation suits well for the translation of important societal questions into global research agendas and for networking actors to co-creation activities. Based on the study, we argue that co-creation offers a socially acceptable approach to address socially critical topics to design transdisciplinary social and sustainability research.
The relationship between existential well-being and mood-related psychiatric burden in Indian young adults with attachment deficits: a cross-cultural validation study
Authors: Hiebler-Ragger Michaela , Kamble Shanmukh V. , Aberer Elisabeth , Unterrainer Human Friedrich 
Published: February 2020

Abstract
Background
Attachment and spirituality are thought to have deep evolutionary roots but are always interpreted within the framework of culture, religion and personal beliefs. While insecure attachment has been observed to be positively related with psychopathology, a positive mental health effect has often been described for spirituality. To examine the cross-cultural validation of previous research focused on Austrian young adults with Western socialization, we attempt to replicate our study examining the influence spirituality has on the connection between insecure attachment and mood-related psychiatric burden with Indian young adults.

Methods
We investigated Avoidant (AV) and Anxious (AX) Attachment (ECR-RD), Religious (RWB) and Existential (EWB) Well-Being (MI-RSWB), and mood-related psychiatric burden (Anxiety, Depression, Somatization; BSI-18) in 443 (31% female) Indian young adults (age range: 18–30 years) with a Hindu upbringing.

Results
Compared to young adults with a Roman Catholic upbringing in a Western socialization, Indian participants did not differ in AX and EWB but scored higher in mood-related psychiatric burden (eta2 = .04), AV (eta2 = .14), as well as RWB (eta2 = .28; all p < .01). As in previous research only AX (β = .40) positively predicted mood-related psychiatric burden (ΔR2 = .15, all p < .01), while EWB was an additional negative predictor (β = −.11, p < .05).

Conclusions
Our findings emphasize the universal importance of attachment and spirituality for mental health as well as the potential influence of socialization on their development.
Furthermore, they underline that Existential Well-Being – including hope for a better future, forgiveness, and the experience of sense and meaning – appears to have a compensating effect on the relation between insecure attachment and impaired mental health.
Cardioprotective effects of the garlic (Allium sativum) in sodium fluoride-treated rats
Authors: Abdel-Baky Enas S. , Abdel-Rahman Omnia N. 
Published: February 2020

Abstract
Background
Excessive intake of fluoride may result in the development of cardiotixicity in the rats. The objective of this study was to investigate the possible cardioprotective effect of the garlic (G) on sodium fluoride (NaF)-treated rats.

Methods
Twenty-four male albino rats (100–120 g), 2 months old, were equally divided into control, NaF, G, and NaF + G groups. Group 1 was control group, the animals without any treatment. Group 2 was administrated with NaF orally (10 mg/kg BWT) daily. Group 3 received orally G alone (63 mg/kg BWT) daily. Group 4 was administrated with NaF + G at the same time (with the same previous doses) daily. The experimental period was for 4 weeks.

Results
NaF significantly elevated the levels of serum creatinine kinase (CK), creatine kinase–MB (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), Aalanine aminotransferase (ALT), and cardiac troponin I (cTnI). Also, there was a significant increase in the total cholesterol (TC), triglycerides (TAG), low-density lipoprotein (LDL-c) fractions, and the atherogenic effect (the mean ratios of TC/LDL-c and LDL-c/ (high-density lipoprotein) HDL-c), whereas a significant decrease in HDL-c occurred in the NaF-treated group compared with the control animals. The treatment with G+NaF ameliorated all the biochemical parameters tested.

Conclusion
These results indicate that garlic has a cardioprotective effect against NaF cardiotoxicity.
Evidence of cognitive training in mild to moderate dementia
Authors: Mohd Nizam Nurul Ain 
Published: February 2020

SUMMARYThere is urgent need to search for a dementia treatment that can delay its progression and reduce its financial and societal burden. Despite lacking evidence, there is a large number of commercial brain-training products on the market that claim they improve cognition. The Cochrane review under consideration looks at whether cognitive training maintains or improves cognition in those with mild to moderate dementia compared with control and alternative interventions. This commentary puts its findings into clinical perspective.
Ivosidenib (IVO; AG-120) in IDH1-mutant newly-diagnosed acute myeloid leukemia (ND AML): Updated results from a phase 1 study.
Authors: Roboz Gail J. , Dinardo Courtney Denton , Stein Eytan M. , de Botton Stéphane , Mims Alice S. , Prince Gabrielle T. , Altman Jessica K. , Arellano Martha Lucia , Erba Harry Paul , Pollyea Daniel Aaron , Stein Anthony Selwyn , Watts Justin M. , Fathi Amir Tahmasb , Kantarjian Hagop M. , Tallman Martin S. , Fan Bin , Liu Hua , Wu Bin , Attar Eyal C. , Stone Richard M. 
Published: February 2020

7028 Background: IVO is an oral, potent, targeted inhibitor of mutant IDH1 (mIDH1) approved for the treatment of adults with mIDH1 relapsed or refractory AML. We report the safety and efficacy of IVO in pts with ND AML not eligible for standard therapy enrolled in the first-in-human, phase 1, dose escalation and expansion study of pts with mIDH1 advanced hematologic malignancies (NCT02074839). Methods: Enrollment completed on 08May2017. Overall response rate (ORR) comprised complete remission (CR) + CR with incomplete hematologic or platelet recovery + partial response + morphologic leukemia-free state. CR with partial hematologic recovery (CRh) was CR except absolute neutrophil count > 0.5 × 109/L and platelet count > 50 × 109/L. Results: Baseline characteristics for 34 pts with ND AML who received IVO 500 mg once daily were: 19 men/15 women; median age 76.5 yrs (range 64-87); 56% ≥75 yrs of age; 76% had secondary AML and 53% prior MDS; 47% had ≥1 hypomethylating agent for an antecedent hematologic disorder. As of 02Nov2018, 7/34 (21%) pts remained on treatment; 3 (9%) had discontinued treatment for allogeneic stem cell transplant. Median duration of IVO exposure was 4.3 mo (range 0.3–40.9). Adverse events of any grade and causality in ≥25% of pts were diarrhea (53%), fatigue (47%), nausea (38%), decreased appetite (35%), leukocytosis, anemia, thrombocytopenia, peripheral edema (all 26%). Most were grade 1–2 and unrelated to treatment. IDH differentiation syndrome (DS) was seen in 6/34 (18%) pts, grade ≥3 in 3 (9%); IVO was held due to DS in 3 pts. QT prolongation was seen in 6 pts. In 33 pts confirmed mIDH1-positive by the companion diagnostic test, CR rate was 30% (95% CI 16%, 49%), CR+CRh 42% (95% CI 26%, 61%), and ORR 55% (95% CI 36%, 72%), with median durations not estimable (95% CI lower bound 4.2, 4.6, and 4.6 mo, respectively); 12-mo response durations were 78%, 62%, and 63%, respectively. Of 21 pts who were transfusion dependent at baseline, 43% became transfusion independent for ≥56 consecutive days on treatment. Updated co-occurring mutation and mutation clearance data will be reported. Conclusions: IVO was well tolerated and induced durable remissions in elderly pts with poor-prognosis mIDH1 ND AML. Clinical trial information: NCT02074839.
Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation
Authors: Holowiecki Andrew , Linstrum Kelsey , Ravisankar Padmapriyadarshini , Chetal Kashish , Salomonis Nathan , Waxman Joshua S. 
Published: February 2020

ABSTRACT
Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size of the later-differentiating outflow tract (OFT). We show that improper specification and proliferation of second heart field (SHF) progenitors in zebrafish lazarus (lzr) mutants, which lack the transcription factor Pbx4, produces enlarged hearts owing to an increase in ventricular and smooth muscle cells. Specifically, Pbx4 initially promotes the partitioning of the SHF into anterior progenitors, which contribute to the OFT, and adjacent endothelial cell progenitors, which contribute to posterior pharyngeal arches. Subsequently, Pbx4 limits SHF progenitor (SHFP) proliferation. Single cell RNA sequencing of nkx2.5+ cells revealed previously unappreciated distinct differentiation states and progenitor subpopulations that normally reside within the SHF and arterial pole of the heart. Specifically, the transcriptional profiles of Pbx4-deficient nkx2.5+ SHFPs are less distinct and display characteristics of normally discrete proliferative progenitor and anterior, differentiated cardiomyocyte populations. Therefore, our data indicate that the generation of proper OFT size and arch arteries requires Pbx-dependent stratification of unique differentiation states to facilitate both homeotic-like transformations and limit progenitor production within the SHF.
CTRL – a label-free artificial intelligence method for dynamic measurement of single-cell volume
Authors: Yao Kai , Rochman Nash D. , Sun Sean X. 
Published: February 2020

ABSTRACT
Measuring the physical size of a cell is valuable in understanding cell growth control. Current single-cell volume measurement methods for mammalian cells are labor intensive, inflexible and can cause cell damage. We introduce CTRL: Cell Topography Reconstruction Learner, a label-free technique incorporating the deep learning algorithm and the fluorescence exclusion method for reconstructing cell topography and estimating mammalian cell volume from differential interference contrast (DIC) microscopy images alone. The method achieves quantitative accuracy, requires minimal sample preparation, and applies to a wide range of biological and experimental conditions. The method can be used to track single-cell volume dynamics over arbitrarily long time periods. For HT1080 fibrosarcoma cells, we observe that the cell size at division is positively correlated with the cell size at birth (sizer), and there is a noticeable reduction in cell size fluctuations at 25% completion of the cell cycle in HT1080 fibrosarcoma cells.
Bufferless III–V photodetectors directly grown on (001) silicon-on-insulators
Authors: Xue Ying , Han Yu , Wang Yi , Zhang Zunyue , Ki Tsang Hon , May Lau Kei 
Published: February 2020

Efficient photodetectors (PDs) and lasers are critical components in silicon photonics technology. Here, we demonstrate bufferless InP/InGaAs PDs, directly grown on (001) silicon-on-insulators. The nano-scale PDs exhibit a high photoresponsivity of 1.06 A/W at 1.55 µm, and a wide operating range from 1450 nm to 1650 nm. The bufferless feature of nano-PDs facilitates effective interfacing with Si waveguides, thus paving the path toward fully integrated silicon photonics circuits.
Transnational Sri Lankan Sinhalese family language policy: Challenges and contradictions at play in two families in the U.S.
Authors: Fuentes Ronald 
Published: February 2020

AbstractThis study examines how the transnational lives of two Sinhalese-speaking Sri Lankan families in the rural U.S. influenced family language policy (FLP) and how they (re)positioned themselves in response to their transnational lives. Employing an ethnographic design, including interviews and observations, this study explores the families’ language ideologies and management strategies and the factors that shaped their policies. Both families held similar language ideologies but contrasting management strategies that were informed by a differing socioeconomic status and eventual home country return, and which in turn led to different ways of FLP formation and implementation. FLPs were aimed at accruing capital and social prestige to facilitate the navigation of spaces in family members’ present and (imagined) future lives in Sri Lanka and the U.S., and possibly beyond; yet, these same policies created a sense of ambivalence in regards to transnationals’ cultural and linguistic identities and attachments. The findings show the competing and contradictory forces at play in transnational bilingual children’s heritage language development. This study draws attention to how transnationals navigate global citizenry and how they make decisions about language as they reimagine and refashion their membership into multiple communities in an interconnected world.
Facile integration of MoS2/SiC photodetector by direct chemical vapor deposition
Authors: Xiao Yifan , Min Long , Liu Xinke , Liu Wenjun , Younis Usman , Peng Tonghua , Kang Xuanwu , Wu Xiaohan , Ding Shijin , Zhang David Wei 
Published: February 2020

Abstract
The MoS2 photodetector on different substrates stacked via van der Waals force has been explored extensively because of its great potential in optoelectronics. Here, we integrate multilayer MoS2 on monocrystalline SiC substrate though direct chemical vapor deposition. The MoS2 film on SiC substrate shows high quality and thermal stability, in which the full width at half-maximum and first-order temperature coefficient for the

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Raman mode are 4.6 cm−1 and −0.01382 cm−1/K, respectively. The fabricated photodetector exhibits excellent performance in the UV and visible regions, including an extremely low dark current of ~1 nA at a bias of 20 V and a low noise equivalent of 10−13–10−15 W/Hz1/2. The maximum responsivity of the MoS2/SiC photodetector is 5.7 A/W with the incident light power of 4.35 μW at 365 nm (UV light). Furthermore, the maximum photoconductive gain, noise equivalent power, and normalized detectivity for the fabricated detector under 365 nm illumination are 79.8, 7.08 × 10−15 W/Hz1/2, and 3.07 × 1010 Jonesat, respectively. We thus demonstrate the possibility for integrating high-performance photodetectors array based on MoS2/SiC via direct chemical vapor growth.
Análisis fenomenológico interpretativo
Authors: Duque Hansel , Aristizábal Díaz-Granados Edith T. 
Published: February 2020

Propósito: Ofrecer una guía metodológica para la implementación del análisis fenomenológico interpretativo (AFI), en especial, para aquellos que se inician en la investigación cualitativa.
Tema: El análisis fenomenológico interpretativo como método para la comprensión de las experiencias personales y su aplicación en el campo de la psicología.
Desarrollo: Se presentan las características generales de la metodología AFI, luego se describen cada una de sus etapas, desde la formulación de la pregunta de investigación y el acceso al campo, hasta la selección de los participantes y la recolección de información. Por último, se describen en detalle las fases y procedimientos para el análisis de datos, así como la redacción y presentación de los resultados.
Conclusión: El análisis fenomenológico interpretativo es un enfoque de investigación cualitativo que busca comprender los significados asociados a la experiencia vivida. En la actualidad, goza de gran reconocimiento y es ampliamente utilizado en el campo de la psicología, especialmente en países de habla inglesa.
Análisis de los factores que inciden en la seguridad alimentaria y nutricional en el Departamento del Quindío y su zona cordillerana
Authors: García Cruz Melina , Rivera Correa David Alejandro , Molina Pérez Jorge Antonio 
Published: February 2020

La seguridad alimentaria y nutricional (SAN), entendida como el estadio en que se garantiza la disponibilidad suficiente y estable de alimentos, acompañada por condiciones de inocuidad y acceso constante para el consumo, es un componente fundamental para el desarrollo de los diferentes grupos humanos; no obstante, la manutención de la misma tiene una relación directa a la sostenibilidad y capacidad del sector agrícola para mantener una oferta que pueda garantizar cantidades suficientes para la población.

Una mirada al contexto local quindiano permite identificar que el abandono del sector agrícola se perfila como un factor de riesgo para la preservación de la seguridad alimentaria, caso del cual da cuenta la siguiente investigación al revisar los casos de los municipios cordilleranos de Córdoba, Pijao, Génova y Buenavista, los cuales presentan un decaimiento de sus condiciones de seguridad alimentaria; situación que se ve generalizada a un departamento en donde la dependencia de mercados foráneos es cada vez mayor, mientras los desincentivos se vuelven mayores para un campesinado con bajas garantías y alta dependencia de monocultivos cuya proliferación condiciona el uso del suelo, disminuye la oferta y variedad de alimentos, deteriorando de esta manera la SAN y en consecuencia la calidad de vida.
Las pymes con sello verde en la globalización
Authors: Castañeda Zapata Daniela , García Londoño Martha Lucía 
Published: February 2020

El presente artículo tiene como finalidad dar a conocer la importancia que están adquiriendo los sellos verdes en el mercado global, siendo este una estrategia de los productores para que el consumidor a través de productos ecológicos que son elaborados a partir de buenas prácticas ambientales logre disminuir el impacto negativo que le genera al medio ambiente.

Además, conocer de qué manera surgen los sellos verdes, la evolución que han tenido, el mercado futurista al que puede llegar, y se centrará en el estado de la dinámica del mercado latinoamericano y su posicionamiento del sello verde; así mismo, permite analizar las ventajas que tiene el sello verde en la modalidad de exportación de un producto o servicio hacia países desarrollados que están en búsqueda de reducir su huella de carbono. No obstante, el estudio se realizó bajo una metodología cualitativa, en el que se establecieron las variables que influyen en el marketing verde, utilizando como tipo de estudio descriptivo y el análisis exploratorio acerca del mercado futurista de los sellos verdes para luego presentar las posturas de los autores en relación al posicionamiento del sello verde en Latinoamérica y su influencia como ventaja competitiva.
Principios constitucionales, generales y procesales en tiempos de víctimas y Justicia Transicional
Authors: Sánchez Gutiérrez Daniela , Llano Franco Jairo Vladimir 
Published: February 2020

Desde los años 90 del siglo pasado las negociaciones entre los grupos insurgentes y el gobierno central en el contexto colombiano han sido una constante, llevando a cabo de forma paulatina una manera de aplicar el derecho que se escapa a los postulados formalistas y positivistas que han predominado por varias décadas la práctica jurídica, esta nueva forma si se puede decir, de aplicar el derecho se ha dado por la influencia tanto del derecho constitucional contemporáneo como por las transformaciones del derecho internacional, particularmente lo relacionado con los Derechos Humanos, configurando otra concepción de justicia donde lo importante no es el castigo, sino la reparación en distintos aspectos y la convivencia de los ciudadanos, como es el caso de la justicia transicional, por eso los principios adquieren un protagonismo inusitado por su amplitud y la posibilidad de resolver múltiples problemas jurídicos como los provenientes de los conflictos armados internos como el colombiano y la posibilidad que una práctica de confrontación de paso acciones de convivencia e inclusión de los ciudadanos. Este artículo se desarrolló mediante la hermenéutica jurídica analizando jurisprudencia de la Corte Constitucional, Leyes, tratados internacionales y conceptos de expertos en justicia transicional. Así pues se evidencio que en el caso de Colombia en el proceso de reparación integral prevalece la reconstrucción de la memora y la verdad así como la no repetición, sobre los demás componentes de dicha reparación que garanticen el cumplimiento de los acuerdos de paz desde la óptica de los principios procesales establecidos por el DIDH.