bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 17124: Severe Bradycardia in Critically Ill Patients With COVID-19
Authors: Larue Julie , De Jode Patrick , Timsit Jean-François , Franchineau Guillaume , Extramiana Fabrice , Algalarrondo Vincent 
Published: November 2020

Cardiac manifestations of severe Covid19 infection are still poorly understood. From January to May 2020, 113 consecutive patients were admitted in intensive care units for severe Covid19 and 10 out of them presented an episode of bradycardia.

Patients had a median age of 63 years, 6/10 were men, 7/10 were under mechanical ventilation for severe acute respiratory distress syndrome and 4/10 received a veno-venous extracorporeal membrane oxygenation. All bradycardias were due to sinus node bradycardia with a median heart rate of 36 bpm (range 10 - 45 bpm). For 6 patients, bradycardia was persistent and 3 required continuous isoprenaline infusion (Figure, patient A). Bradycardia was sudden for 4 patients and required brief resuscitation maneuvers for one (Figure, patient B)
.
Patients had normal baseline ECG and echocardiography, except for two patients who were under beta-blockers. For those two patients beta blockers were interrupted several days before bradycardia. A comprehensive review of patient’s files ruled out bradycardia due to drug-drug interactions, myocarditis, hyperkalemia, hypoxia or vagal physical stimulation. Holter ECG was performed for 7 patients: 3 recordings evoked vagal hyperactivity (low mean heart rate and elevated pNN50 / RMSSD, Figure Patient A), 3 others cardiac dysautonomia (SDNN<100ms, Figure Patient B).

Amongst these 10 patients, 5 were discharged from ICU among which 2 returned home and five died from covid-19 associated multiple-organ failure. None of them required temporary or permanent cardiac pacing.
To conclude, sinus bradycardia occurred commonly in severe Covid19 infection. This highlights the need to monitor cardiac rhythm. Even if the pathophysiology remains unclear, cardiac dysautonomia and vagal hyperactivity could be hypothesized rather than an intrinsic sinus node disease.
Sources of Hospital Variation in Postacute Care Spending After Cardiac Surgery
Authors: Thompson Michael P. , Yost Monica L. , Syrjamaki John D. , Norton Edward C. , Nathan Hari , Theurer Patricia , Prager Richard L. , Pagani Francis D. , Likosky Donald S. 
Published: November 2020

Background:
Postacute care is a major driver of cardiac surgical episode spending, but the sources of variation in spending have not been explored. The objective of this study was to identify sources of variation in postacute care spending within 90-days of discharge following coronary artery bypass grafting (CABG) and aortic valve replacement (AVR) and the relationship between postacute care spending and other postdischarge utilization.

Methods and Results:
A retrospective analysis was conducted of public and private administrative claims for Michigan residents insured by Medicare fee-for-service and Blue Cross Blue Shield of Michigan/Blue Care Network commercial and Medicare Advantage plans undergoing CABG (n=11 208) or AVR (n=6122) in 33 nonfederal acute care Michigan hospitals between January 1, 2015 and December 31, 2018. Postacute care use was present in 9662 (86.2%) CABG episodes and 4242 (69.3%) AVR episodes, with respective mean (SD) 90-day spending of $4398±$6124 and $3465±$5759. Across hospitals, mean postacute care spending ranged from $3280 to $8186 for CABG and $2246 to $7710 for AVR. Inpatient rehabilitation and skilled nursing facility care accounted for over 80% of the variation spending between low and high postacute care spending hospitals. At the hospital-level, postacute care spending was modestly correlated across procedures and payers. Spending associated with readmissions, emergency department visits, and outpatient facility care was significantly different between low and high postacute care spending hospitals in CABG and AVR episodes.

Conclusions:
There was wide hospital variation in postacute care spending after cardiac surgery, which was primarily driven by differential use and intensity in facility-based postacute care. Optimizing facility-based postacute care after cardiac surgery offers unique opportunities to reduce potentially unwarranted care variation.
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF
Authors: Deng Yan , Xie Maodi , Li Qian , Xu Xuewen , Ou Wei , Zhang Yabing , Xiao Haitao , Yu Hai , Zheng Yanyi , Liang Yu , Jiang Chunling , Chen Guo , Du Dan , Zheng Wen , Wang Shisheng , Gong Meng , Chen Yaohui , Tian Rong , Li Tao 
Published: November 2020

Rationale:
Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than reduced ejection fraction. Complexity of its pathophysiology and the lack of animal models hamper the development of effective therapy for HFpEF.

Objective:
This study was designed to investigate the metabolic mechanisms of HFpEF and test therapeutic interventions using a novel animal model.

Methods and Results:
By combining the age, long-term high-fat diet, and desoxycorticosterone pivalate challenge in a mouse model, we were able to recapture the myriad features of HFpEF. In these mice, mitochondrial hyperacetylation exacerbated while increasing ketone body availability rescued the phenotypes. The HFpEF mice exhibited overproduction of IL (interleukin)-1β/IL-18 and tissue fibrosis due to increased assembly of NLPR3 inflammasome on hyperacetylated mitochondria. Increasing β-hydroxybutyrate level attenuated NLPR3 inflammasome formation and antagonized proinflammatory cytokine–triggered mitochondrial dysfunction and fibrosis. Moreover, β-hydroxybutyrate downregulated the acetyl-CoA pool and mitochondrial acetylation, partially via activation of CS (citrate synthase) and inhibition of fatty acid uptake.

Conclusions:
Therefore, we identify the interplay of mitochondrial hyperacetylation and inflammation as a key driver in HFpEF pathogenesis, which can be ameliorated by promoting β-hydroxybutyrate abundance.
Being-towards-Eternity: R. Isaac Hutner’s Adaptation of a Heideggerian Notion
Authors: Herskowitz Daniel , Shalev Alon 
Published: November 2020

Abstract
In his writings, Rabbi Isaac Hutner integrated various insights from secular philosophy and particularly from existentialist thought. Concerns regarding temporality, authenticity, and death permeate his thought. This article deals with what we call “being-towards-eternity,” a modification of Martin Heidegger’s “being-towards-death,” through which Hutner seeks to reconcile genuine anxiety in the face of finitude with an unwavering belief in resurrection and life after death. Hutner’s appropriation and adaptation of this Heideggerian notion demonstrates how he adopted secular ideas while cautiously remaining within the boundaries of traditional Jewish concerns and vocabulary.
Whose Best Friend? Muslims, Dogs, and the Making of American Humanity
Authors: Kharputly Nadeen 
Published: November 2020

Abstract
This article examines the relationship between Muslims, dogs, and the constitution of American humanity. While existing scholarship has explored scriptural portrayals of dogs in Islam, the article focuses on the cultural effects of this perceived hostility towards dogs in the U.S. and situates this hostility within the legacy of canine abuse against bodies of color in the U.S. These historical links demonstrate the use of dogs in the dehumanization of communities of color in the U.S. and against Muslims specifically.
Attention-getting in a white-cheeked gibbon by means of a novel vocalization?
Authors: Caspar Kai R. , Kammerer Caroline , Hradec Michal 
Published: November 2020

Abstract
Gibbons (family Hylobatidae) are renowned for their melodious territorial songs but other aspects of their acoustic communication have received little research attention. Here we describe an apparently novel idiosyncratic non-song vocalization in an adult captive Southern white-cheeked gibbon (Nomascus siki), which we suggest acts specifically in attracting a human’s attention. For this preliminary report we analysed 25 individual calls recorded over a period of 6 months. Typically, calling is accompanied by clapping and feet-slapping, behaviours not reported from gibbons in comparable situations so far. The utilization of both innovative vocalizations and other acoustic displays as human-directed attention getters, reminiscent of our white-cheeked gibbon subject, is known from great apes, which further suggests a concordant behavioural function. However, the gibbon’s displays, despite their unequivocal novelty, could also represent unintentional behavioural responses related to frustration. Eventually, experimental approaches are required to clarify what underlies this unusual behaviour.
To Withdraw or Not to Withdraw: A Structural Analysis of the Scope and Limits of Voluntary Withdrawal of Criminal Attempt in the Rome Statute
Authors: Vuletić Igor 
Published: November 2020

Abstract
Voluntary withdrawal of criminal attempt is one of the fundamental institutes of the general part of criminal law, originally codified in international criminal law in the Rome Statute. Since the Statute attributed significant legal effects to withdrawal, which excludes the liability for criminal attempt, it is important to establish a clear understanding on its scope and limitations. This article analyses controversial issues related to the legal nature of withdrawal as grounds for exclusion of criminal liability, withdrawal of individual offenders and accomplices, and provides interpretations on potential solutions for these issues. The analysis is based on the subjective conception of withdrawal, under which its essence lays in the rejection of the initial criminal intent, while taking into consideration withdrawal in the context of international crime. Based on the analysis, an original three-level test for the determination of withdrawal in the future practice of the International Criminal Court, (icc) is proposed.
Jonathan Leaman: In Conversation
Authors: Goldman-Ida Batsheva 
Published: November 2020

Abstract

Jonathan Leaman (b. 1954, London) is a British painter who is represented in the Tate Collection. This article, the result of 15 years of his correspondence with art historian and museum curator Batsheva Goldman-Ida, focuses on a group of works by the artist from the last two decades. Leaman’s familiarity with major Kabbalah scholarship, combined with his wide knowledge of poetry and philosophy, enable him to engage in concepts related to Kabbalah and art in a discursive manner that is unparalleled in modern scholarship. This article showcases Leaman’s remarks with source material for the benefit of the reader. Leaman is one of the most important contemporary artists in the area of mystical art. His introduction to the public is long overdue. His paintings are an authentic, creative expression of the considered material filtered through the artist’s own self-awareness. Leaman’s keen interest in haecceity, hypostatization, and reification is juxtaposed with Goldman-Ida’s interest in object history and linguistic mysticism, and with key Hasidic and kabbalistic concepts such as worship through corporeality, divine contraction, and rectification.
Cosmopolitanism in Dubai’s Pan-Arab Drama
Authors: Haddad Fadi G. , Dhoest Alexander 
Published: November 2020

Abstract
Pan-Arab dramas (Ar. al-drama al-ʿarabiyya al-mushtaraka) are a recent trend in Arabic drama series (Ar. musalsalat); they portray an ensemble of characters of various Arab nationalities in a transnational narrative setting. By considering transnational television a factor that contributes to the cosmopolitan imagination, and given the argument that Gulf cities are replacing historical Arab capitals and becoming ‘new centers’ for Arab culture, education and business, we explore the manner in which cosmopolitanism is represented in transnational Arab drama content. We do this through a case study of ‘04’ (Zero Four), a pan-Arab drama series that tells the story of four young expatriates of four Arab nationalities, experiencing their personal, professional and private lives in modern-day Dubai. We find that the boundaries of the cosmopolitan imagined community encompass the Arab world, resulting in a cosmopolitan imaginary that seems to favor Arabs over non-Arabs.
Degree of Commitment (diqi) and Differential Peasant Resistance in Three Village Communities
Authors: Wang Xiao , Tong Ying 
Published: November 2020

Abstract
Centering on an analysis of the role of diqi, or the degree of commitment underlying one’s self-confidence and actions, this study investigates villagers’ differential responses to the same project of demolition of local residences in three neighboring communities in order to understand the psychological mechanism through which peasant resistance came to be differentiated. It is found that what sustained peasant actions was their shared moral commitment to a way of life rather than self-interest or rational reasoning. Different also from James Scott’s “subsistence ethic” or Ying Xing’s ethical power “qi,” however, what the villagers stressed was an “everyday ethic” that sought to preserve their current way of life. Their resistance took different forms because of the different levels of commitment (diqi) that influenced their choice of actions despite the same kind of impact on their ethic of everyday life. To protect the rights and interests of rural residents and alleviate their resistance, it is necessary to give weight to the ethic of the everyday way of life of villagers instead of the logic of capital and to pay attention to the fundamental concerns of the silent majority in rural China.
Ray properties in the stems of Dahurian larch (Larix gmelinii) and Japanese larch (Larix kaempferi)
Authors: Kim Do Hoon , Kim Seong Hyun , Jo Jae Ik , Kim Jong Ho , Purusatama Byantara Darsan , Lee Seung Hwan , Kim Nam Hun 
Published: November 2020

Abstract
The radial variation of rays within the stems of Dahurian larch and Japanese larch growing in Korea was studied to obtain valuable information to identify the two species and determine wood quality. Uniseriate ray height, fusiform ray height, ray number, ray spacing, and epithelial cell number were investigated by optical microscopy. The heights of uniseriate and fusiform rays and epithelial cell numbers in Dahurian larch were lower than those in Japanese larch. Dahurian larch wood had greater ray number and ray spacing than Japanese larch wood. In both species, the heights of uniseriate and fusiform rays and epithelial cell number increased with increasing growth ring number but then stabilized from a certain growth ring number. However, ray number and ray spacing decreased with age but were stable toward the bark. There were significant differences in all ray properties between the two species. Furthermore, in both species, the number and spacing of rays showed a significant negative correlation with uniseriate ray height. The relationships between uniseriate and fusiform ray height, and between ray spacing and ray number were significantly positive. In conclusion, the results from this study provide basic information that can be used to identify these species, and the quality indices from ray properties will improve the effective utilization of the two woody species.
Disparate Midlatitude Responses to the Eastern Pacific El Niño
Authors: Shiozaki Masahiro , Enomoto Takeshi , Takaya Koutarou 
Published: November 2020

AbstractTo investigate the disparate influences of the eastern Pacific (EP) El Niño on the winter climate in the Far East, we conducted composite analyses using long-term reanalysis datasets. Our analysis shows that the western Pacific (WP) pattern dominates in the warm winter (typical) composite and the Pacific–North American (PNA) pattern dominates in the non-warm winter (atypical) composite. In the warm winter case, the amplitudes of the negative sea surface temperature (SST) anomalies in the western Pacific Ocean are large whereas in the non-warm winter case, these amplitudes are small. In addition, the Indian Ocean basin warming occurs following the Indian Ocean dipole mode, as seen in the warm winter composite. We investigated the dynamical mechanisms responsible for the disparate midlatitude responses to the EP El Niño by focusing on Rossby wave sources and propagation. These SST anomalies modulate the Walker and Hadley circulations and the convective activity in the western Pacific Ocean. Upper-tropospheric divergences at the midlatitudes due to the anomalous Hadley circulation result in different teleconnection patterns. In the warm winter composite, the anticyclonic anomaly in the southern part of the WP pattern is created by the upstream negative Rossby wave source, while the other cyclonic anomaly is reinforced by the northward Rossby wave propagation. The cyclonic second and fourth centers of action of the PNA pattern are created by the positive Rossby wave sources. Furthermore, the equatorial SST gradient near the date line is found be a good precursor of the winter climate in the Far East.
Development and Testing of the AXBT Real-Time Editing System (ARES)
Authors: Densmore Casey R. , Jayne Steven R. , Sanabia Elizabeth R. 
Published: November 2020

AbstractAirborne expendable bathythermographs (AXBTs) are air-launched, single-use temperature–depth probes that telemeter temperature observations as VHF-modulated frequencies. This study describes the AXBT Real-Time Editing System (ARES), which is composed of two components: the ARES Data Acquisition System, which receives telemetered temperature–depth profiles with no external hardware other than a VHF radio receiver, and the ARES Profile Editing System, which quality controls AXBT temperature–depth profiles. The ARES Data Acquisition System performs fast Fourier transforms on windowed segments of the demodulated signal transmitted from the AXBT. For each segment, temperature is determined from peak frequency and depth from elapsed time since profile start. Valid signals are distinguished from noise by comparing peak signal levels and signal-to-noise ratios to predetermined thresholds. When evaluated using 387 profiles, the ARES Data Acquisition System produced temperature–depth profiles nearly identical to those generated using a Sippican MK-21 processor, while reducing the amount of noise from VHF interference included in those profiles. The ARES Profile Editor applies a series of automated checks to identify and correct common profile discrepancies before displaying the profile on an editing interface that provides simple user controls to make additional corrections. When evaluated against 1177 tropical Atlantic and Pacific AXBT profiles, the ARES automated quality control system successfully corrected 87% of the profiles without any required manual intervention. Necessary future work includes improvements to the automated quality control algorithm and algorithm evaluation against a broader dataset of temperature–depth profiles from around the world across all seasons.
Effect of sildenafil citrate on treatment of infertility in women with a thin endometrium: a systematic review and meta-analysis
Authors: Li Xin , Luan Ting , Zhao Chun , Zhang Mianqiu , Dong Li , Su Yan , Ling Xiufeng 
Published: November 2020

Objective Endometrial thickness is a prognostic factor for successful pregnancy. This meta-analysis aimed to examine the role of sildenafil citrate on infertile women with a thin endometrium. Methods Two investigators independently searched the literature on sildenafil citrate and infertile women with a thin endometrium from PubMed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to January 2019. Results Nine studies involving 1452 patients were included for analysis in our study. We found that endometrial thickness in patients who received sildenafil citrate was significantly higher than that in the control group (placebo or no treatment) (weighted mean difference: 1.22; 95% confidence interval [CI]: 1.07–1.38). The radial artery resistance index was significantly lower (weighted mean difference: −0.12; 95% CI: −0.17 to −0.06), and the clinical pregnancy rate (risk ratio: 1.31; 95% CI: 1.11–1.53) and biochemical pregnancy rate (risk ratio: 1.45; 95% CI: 1.11–1.89) were significantly higher in the sildenafil citrate group compared with the control group. Conclusion Sildenafil citrate is effective in improving endometrial thickness, the clinical pregnancy rate, and the biochemical pregnancy rate in women who have a thin endometrium. This treatment is a potential therapeutic intervention for a thin endometrium.
Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase 1/2 trial
Authors: Le Gouill Steven , Morschhauser Franck , Chiron David , Bouabdallah Krimo , Cartron Guillaume , Casasnovas Olivier , Bodet-Milin Caroline , Ragot Sylviane , Bossard Céline , Nadal Nathalie , Herbaux Charles , Tessoulin Benoit , Tchernonog Emmanuelle , Rossi Cédric , McCulloch Rory , Gastinne Thomas , Callanan Mary B. , Rule Simon 
Published: November 2020

Abstract
Ibrutinib, obinutuzumab, and venetoclax demonstrate synergy in preclinical models of mantle cell lymphoma (MCL). OAsIs (NCT02558816), a single-arm multicenter prospective phase 1/2 trial, aimed to determine the maximum tolerated dose of venetoclax in combination with fixed doses of ibrutinib and obinutuzumab, in relapsed MCL patients. At the venetoclax MTD, extension cohorts were opened for relapsed and untreated patients. Safety and efficacy were secondary objectives. Minimal residual disease (MRD) was assessed by allele-specific oligonucleotide quantitative polymerase chain reaction. Between 14 October 2015 and 29 May 2018, 48 patients were enrolled. No dose-limiting toxicity was reported, and venetoclax at 400 mg per day was chosen for extension. Eighteen (75%) relapsed and 8 (53%) untreated patients experienced grade 3/4 adverse events. The complete response rate assessed by positron emission tomography at the end of cycle 6 was 67% in relapsed and 86.6% in untreated patients. MRD clearance for evaluable patients was seen in 71.5% of relapsed (10/14 patients) and 100% of untreated MRD-evaluable patients (n = 12) at the end of 3 cycles. The median follow-up for relapsed patients was 17 months (range, 10-35 months). The 2-year progression-free survival (PFS) was 69.5% (95% confidence interval [CI], 52.9%-91.4%) and 68.6% (95% CI, 49.5%-95.1%) for overall survival. The median follow-up was 14 months (range, 5-19) for untreated patients, the 1-year PFS was 93.3% (95% CI, 81.5%-100%). The combination of obinutuzumab, ibrutinib, and venetoclax is well tolerated and provides high response rates, including at the molecular level, in relapsed and untreated MCL patients. This trial was registered at www.clinicaltrials.gov as #NCT02558816.
Enhanced Optical Absorption in Perovskite/Si Tandem Solar Cells with Nanoholes Array
Authors: Kuang Yawei , Ma Yulong , Zhang Debao , Wei Qingzhu , Wang Shuchang , Yang Xifeng , Hong Xuekun , Liu Yushen 
Published: November 2020

Abstract
Perovskite solar cells are used in silicon-based tandem solar cells due to their tunable band gap, high absorption coefficient and low preparation cost. However, the relatively large optical refractive index of bottom silicon, in comparison with that of top perovskite absorber layers, results in significant reflection losses in two-terminal devices. Therefore, light management is crucial to improve photocurrent absorption in the Si bottom cell. In this paper, nanoholes array filled with TiO2 is introduced into bottom cells design. By finite-difference time-domain methods, the absorption efficiency and photocurrent density in the range of 300–1100 nm has been analyzed, and the structural parameters have been also optimized. Our calculations show the photocurrent density which tends to be saturated with the increase in the height of the nanoholes. The absorption enhancement modes of photons at different wavelengths have been analyzed intuitively by the distribution of electric field. These results enable a viable and convenient route toward high efficiency design of perovskite/Si tandem solar cells.