bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Mental Health First Aid from the Perspective Of Workplace End UseRs—EMPOWER: protocol of cluster randomised trial phase
Authors: Atanda Opeyemi , Callaghan Patrick , Carter Tim , Durcan Graham , O’Shea Nick , Brown Steve D. , Reavey Paula , Vangeli Eleni , White Sarah , Wood Kerry V. 
Published: August 2020

Abstract
Background
Mental Health First Aid (MHFA) is a mental health intervention that teaches people how to identify, understand and help someone who may be experiencing a mental health issue. Reviews of the implementation of MHFA found between 68 and 88% of trained Mental Health First Aiders had used their skills when in contact with someone experiencing mental health difficulties. Reviews evaluating the impact of MHFA suggest positive outcomes. However, to date, there has been no systematic, rigorous evaluation of the impact of MHFA on recipients of the intervention, the organisations providing it and the cost-effectiveness of MHFA overall. This trial will evaluate the effectiveness and cost-effectiveness of MHFA.

Methods
The study is a multi-centred, two-arm clustered randomised controlled trial. Organisations will be randomly allocated to the control or intervention (estimated sample size 800 recipients). The intervention is the standard MHFA intervention provided by Mental Health First Aid England (MHFAE). The control condition will be organisations having a brief consultation from MHFAE on promoting mental health and well-being in the workplace. The primary outcome is health seeking behaviour, measured using the Actual Help Seeking Questionnaire, at 6 months’ follow-up. Data collection will be undertaken at baseline (T0), post-intervention—up to 3 months (T1), at 6 months (T2), 12 months (T3) and 24 months (T4). The primary analysis will be conducted on those participants who receive MHFA, a per protocol analysis.

Discussion
The study is the first to evaluate the effect of MHFA in the workplace on employees with direct and indirect experience of the intervention, when compared with usual practice. Being also the first to assess, systematically, the social impact of MHFA and investigate its cost-effectiveness adds to the originality of the study. The study promises to yield important data, as yet unknown, regarding the effectiveness, cost-effectiveness, implementation issues, and the sustainability of MHFA in the workplace.

Trial registration
Clinicaltrials.govNCT04311203. Registered on 17 March 2020.
Ovarian dysfunction with moderate-dose intravenous cyclophosphamide (modified NIH regimen) and mycophenolate mofetil in young adults with severe lupus: a prospective cohort study
Authors: Sharma Shefali Khanna , Jain Siddharth , Bahl Pooja , Potturi Pragna , Rathi Manish , Naidu Shankar , Sachdeva Naresh , Dhir Varun , Jain Sanjay 
Published: August 2020

Abstract
Background
Ovarian toxicity is a dreaded complication of cyclophosphamide (CYC). With the use of lower cumulative doses of intravenous CYC (modified NIH regimens) and availability of better markers of ovarian toxicity, the incidence of ovarian dysfunction needs reassessment. Lupus disease activity, by itself, is also believed to affect ovarian function negatively.

Methods
This single-centre prospective cohort study recruited 50 female patients of severe lupus aged 18–40 years. Twenty-five patients each received induction with either monthly intravenous CYC (0.5–0.75 g/m2) for 6–9 months or daily oral mycophenolate mofetil (MMF). Details of menstrual irregularities; serum levels of FSH, LH, estradiol, AMH, and inhibin B; and sonographic assessment of ovarian volume and antral follicular count were done at baseline and 6 months after treatment. Amenorrhoeic patients were re-evaluated at 1 year.

Results
Mean (SD) age of subjects in the CYC and MMF groups was 31.4 (6.3) and 28.4 (4.4) years, respectively. Mean (SD) SLEDAI at the initiation of therapy was 7.2 (2.5) in the CYC group and 5.8 (3.4) in the MMF group. The mean cumulative dose of CYC used was 4.6 (1.8) g. Three patients in the CYC group (versus none in MMF) had amenorrhoea at 6 months—two of these regained menses within 6 months, while only one (4%) developed sustained amenorrhoea (lasting more than 12 months) at 41 years of age, likely menopause. Serum FSH levels increased (p = 0.03), while AMH (p = 0.002) and inhibin B (p < 0.001) levels decreased significantly with 6 months of CYC therapy. Ovarian volume also reduced significantly (p = 0.005) with 6 months of CYC therapy, while antral follicular count reduced numerically (p = 0.32). Levels of AMH, inhibin-B, estradiol, ovarian volume, and antral follicular count after 6 months therapy were significantly lesser in the CYC group compared to the MMF group, despite being similar before the start of therapy.

Conclusions
Ovarian dysfunction with monthly intravenous CYC (modified NIH regimen) was predominantly subclinical, with a negative effect on ovarian reserve. No premature ovarian failure was noted at 1 year. No ovarian dysfunction occurred in the MMF group, despite having patients with severe background lupus. Use of intravenous CYC for induction may thus not be restricted in young lupus females with incomplete families for fear of gonadotoxicity, especially in life- or organ-threatening situations, where the benefits outweigh this subclinical risk.
Molecular characteristics of the VP1 region of enterovirus 71 strains in China
Authors: Sun Haiyan , Gao Min , Cui Dawei 
Published: August 2020

AbstractBackgroundEnterovirus 71 (EV71) is the most commonly implicated causative agent of severe outbreaks of paediatric hand, foot, and mouth disease (HFMD).VP1 protein, a capsid protein of EV71, is responsible for the genotype of the virus and is essential for vaccine development and effectiveness. However, the genotypes of EV71 isolates in China are still not completely clear.MethodsThe VP1 gene sequences of 3712 EV71 virus strains from China, excluding repetitive sequences and 30 known EV71 genotypes as reference strains, between 1986 and 2019 were obtained from GenBank. Phylogenetic tree, amino acid homology, genetic variation and genotype analyses of the EV71VP1 protein were performed with MEGA 6.0 software.ResultsThe amino acid identity was found to be 88.33%–100% among the 3712 EV71 strains, 93.47%–100% compared with vaccine strain H07, and 93.04%–100% compared with vaccine strains FY7VP5 or FY-23 K-B. Since 2000, the prevalent strains of EV71 were mainly of the C4 genotype. Among these, the C4a subgenotype was predominant, followed by the C4b subgenotype; other subgenotypes appeared sporadically between 2005 and 2018 in mainland China. The B4 genotype was the main genotype in Taiwan, and the epidemic strains were constantly changing. Some amino acid variations in VP1 of EV71 occurred with high frequencies, including A289T (20.99%), H22Q (16.49%), A293S (15.95%), S283T (15.11%), V249I (7.76%), N31D (7.25%), and E98K (6.65%).ConclusionThe C4 genotype of EV71 in China matches the vaccine and should effectively control EV71. However, the efficacy of the vaccine is partially affected by the continuous change in epidemic strains in Taiwan. These results suggest that the genetic characteristics of the EV71-VP1 region should be continuously monitored, which is critical for epidemic control and vaccine design to prevent EV71 infection in children.
Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells
Authors: Li Huilin , Pei Haiyun , Wang Sihan , Zhang Bowen , Fan Zeng , Liu Yiming , Xie Xiaoyan , Yang Zhou , Xu Lei , Jia Yali , Bai Yun , Han Yi , Chen Lin , He Lijuan , Nan Xue , Yue Wen , Pei Xuetao 
Published: August 2020

AbstractBackgroundAlthough cord blood (CB) offers promise for treatment of patients with high-risk hematological malignancies and immune disorders, the limited numbers of hematopoietic stem cell (HSC)/progenitor cell in a CB unit and straitened circumstances in expanding ex vivo make it quite challenging to develop the successful cell therapies.MethodsIn this study, a novel strategy has been developed to support ex vivo expansion of hematopoietic stem and progenitor cells (HSPCs) by coculture with engineered human umbilical arterial endothelial cells (HuAECs-E4orf1-GFP), which expressesE4ORF1stably by using a retroviral system.ResultsCoculture of CD34+hCB cells with HuAECs-E4orf1-GFP resulted in generation of considerably more total nucleated cells, CD34+CD38−, and CD34+CD38−CD90+HSPCs in comparison with that of cytokines alone or that of coculture with human umbilical vein endothelial cells (HuVECs) after 14-day amplification. The in vitro multilineage differentiation potential and in vivo repopulating capacity of the expanded hematopoietic cells cocultured with HuAECs-E4orf1-GFP were also markedly enhanced compared with the other two control groups. DLL4, a major determinant of arterial endothelial cell (EC) identity, was associated with CD34+hCB cells amplified on HuAECs-E4orf1-GFP.ConclusionsCollectively, we demonstrated that HuAECs acted as a permissive niche in facilitating expansion of HSPCs. Our study further implicated that the crucial factors and related pathways presented in HuAECs may give a hint to maintain self-renewal of bona fide HSCs.
Quantitative comparison of pre-treatment predictive and post-treatment measured dosimetry for selective internal radiation therapy using cone-beam CT for tumor and liver perfusion territory definition
Authors: Jafargholi Rangraz Esmaeel , Tang Xikai , Van Laeken Charlotte , Maleux Geert , Dekervel Jeroen , Van Cutsem Eric , Verslype Chris , Baete Kristof , Nuyts Johan , Deroose Christophe M. 
Published: August 2020

Abstract
Background
Selective internal radiation therapy (SIRT) is a promising treatment for unresectable hepatic malignancies. Predictive dose calculation based on a simulation using 99mTc-labeled macro-aggregated albumin (99mTc-MAA) before the treatment is considered as a potential tool for patient-specific treatment planning. Post-treatment dose measurement is mainly performed to confirm the planned absorbed dose to the tumor and non-tumor liver volumes. This study compared the predicted and measured absorbed dose distributions.

Methods
Thirty-one patients (67 tumors) treated by SIRT with resin microspheres were analyzed. Predicted and delivered absorbed dose was calculated using 99mTc-MAA-SPECT and 90Y-TOF-PET imaging. The voxel-level dose distribution was derived using the local deposition model. Liver perfusion territories and tumors have been delineated on contrast-enhanced CBCT images, which have been acquired during the 99mTc-MAA work-up. Several dose-volume histogram (DVH) parameters together with the mean dose for liver perfusion territories and non-tumoral and tumoral compartments were evaluated.

Results
A strong correlation between the predicted and measured mean dose for non-tumoral volume was observed (r = 0.937). The ratio of measured and predicted mean dose to this volume has a first, second, and third interquartile range of 0.83, 1.05, and 1.25. The difference between the measured and predicted mean dose did not exceed 11 Gy. The correlation between predicted and measured mean dose to the tumor was moderate (r = 0.623) with a mean difference of − 9.3 Gy. The ratio of measured and predicted tumor mean dose had a median of 1.01 with the first and third interquartile ranges of 0.58 and 1.59, respectively. Our results suggest that 99mTc-MAA-based dosimetry could predict under or over dosing of the non-tumoral liver parenchyma for almost all cases. For more than two thirds of the tumors, a predictive absorbed dose correctly indicated either good tumor dose coverage or under-dosing of the tumor.

Conclusion
Our results highlight the predictive value of 99mTc-MAA-based dose estimation to predict non-tumor liver irradiation, which can be applied to prescribe an optimized activity aiming at avoiding liver toxicity. Compared to non-tumoral tissue, a poorer agreement between predicted and measured absorbed dose is observed for tumors.
Effects of exercise therapy in patients with acute low back pain: a systematic review of systematic reviews
Authors: Karlsson Marc , Bergenheim Anna , Larsson Maria E. H. , Nordeman Lena , van Tulder Maurits , Bernhardsson Susanne 
Published: August 2020

AbstractBackgroundAcute low back pain is associated with pain and disability, but symptoms are often self-healing. The effectiveness of exercise therapy for acute low back pain remains uncertain with conflicting evidence from systematic reviews. The aim of this systematic review of systematic reviews was to assess the overall certainty of evidence for the effects of exercise therapy, compared with other interventions, on pain, disability, recurrence, and adverse effects in adult patients with acute low back pain.MethodsPubMed, the Cochrane library, CINAHL, PEDro, Open Grey, Web of Science, and PROSPERO were searched for systematic reviews of randomized controlled trials. Methodological quality was assessed independently by two authors using AMSTAR. Meta-analyses were performed if possible, using data from the original studies. Data for pain, disability, recurrence, and adverse effects were analyzed. Certainty of evidence was assessed using GRADE.ResultsThe searches retrieved 2602 records, of which 134 publications were selected for full-text screening. Twenty-four reviews were included, in which 21 randomized controlled trials (n= 2685) presented data for an acute population, related to 69 comparisons. Overlap was high, 76%, with a corrected covered area of 0.14. Methodological quality varied from low to high. Exercise therapy was categorized into general exercise therapy, stabilization exercise, and McKenzie therapy. No important difference in pain or disability was evident when exercise therapy was compared with sham ultrasound, nor for the comparators usual care, spinal manipulative therapy, advice to stay active, and educational booklet. Neither McKenzie therapy nor stabilization exercise yielded any important difference in effects compared with other types of exercise therapy. Certainty of evidence varied from very low to moderate.ConclusionsThe findings suggest very low to moderate certainty of evidence that exercise therapy may result in little or no important difference in pain or disability, compared with other interventions, in adult patients with acute low back pain. A limitation of this systematic review is that some included reviews were of low quality. When implementing findings of this systematic review in clinical practice, patients’ preferences and the clinician’s expertise also should be considered, to determine if and when exercise therapy should be the intervention of choice.Systematic review registrationPROSPERO: CRD46146, available at:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=46146.
Boundary shape function method for nonlinear BVP, automatically satisfying prescribed multipoint boundary conditions
Authors: Liu Chein-Shan , Chang Chih-Wen 
Published: August 2020

AbstractIt is difficult to exactly and automatically satisfy nonseparable multipoint boundary conditions by numerical methods. With this in mind, we develop a novel algorithm to find solution for a second-order nonlinear boundary value problem (BVP), which automatically satisfies the multipoint boundary conditions prescribed. A novel concept of boundary shape function (BSF) is introduced, whose existence is proven, and it can satisfy the multipoint boundary conditions a priori. In the BSF, there exists a free function, from which we can develop an iterative algorithm by letting the BSF be the solution of the BVP and the free function be another variable. Hence, the multipoint nonlinear BVP is properly transformed to an initial value problem for the new variable, whose initial conditions are given arbitrarily. The BSF method (BSFM) can find very accurate solution through a few iterations.
Further generalizations of Hadamard and Fejér–Hadamard fractional inequalities and error estimates
Authors: Rao Yongsheng , Yussouf Muhammad , Farid Ghulam , Pečarić Josip , Tlili Iskander 
Published: August 2020

AbstractThe aim of this paper is to generalize the fractional Hadamard and Fejér–Hadamard inequalities. By using a generalized fractional integral operator containing extended Mittag-Leffler function via monotone function, for convex functions we generalize well known fractional Hadamard and Fejér–Hadamard inequalities. Also we study the error bounds of these generalized Hadamard and Fejér–Hadamard inequalities. We also obtain some published results from presented inequalities.
Dynamics of a fractional order mathematical model for COVID-19 epidemic
Authors: Zhang Zizhen , Zeb Anwar , Egbelowo Oluwaseun Francis , Erturk Vedat Suat 
Published: August 2020

AbstractIn this work, we formulate and analyze a new mathematical model for COVID-19 epidemic with isolated class in fractional order. This model is described by a system of fractional-order differential equations model and includes five classes, namely, S (susceptible class), E (exposed class), I (infected class), Q (isolated class), and R (recovered class). Dynamics and numerical approximations for the proposed fractional-order model are studied. Firstly, positivity and boundedness of the model are established. Secondly, the basic reproduction number of the model is calculated by using the next generation matrix approach. Then, asymptotic stability of the model is investigated. Lastly, we apply the adaptive predictor–corrector algorithm and fourth-order Runge–Kutta (RK4) method to simulate the proposed model. Consequently, a set of numerical simulations are performed to support the validity of the theoretical results. The numerical simulations indicate that there is a good agreement between theoretical results and numerical ones.
Estimates of quantum bounds pertaining to new q-integral identity with applications
Authors: Awan Muhammad Uzair , Talib Sadia , Kashuri Artion , Noor Muhammad Aslam , Chu Yu-Ming 
Published: August 2020

AbstractIn this article, we establish a new generalized q-integral identity involving a q-differentiable function. Using this new auxiliary result, we obtain some new associated quantum bounds essentially using the class of preinvex functions. At the end, we present some applications to the special bivariate means to show the significance of the obtained results. Our approaches and obtained results may lead to further applications in physics.
Analysis of dengue model with fractal-fractional Caputo–Fabrizio operator
Authors: Fatmawati  , Khan Muhammad Altaf , Alfiniyah Cicik , Alzahrani Ebraheem 
Published: August 2020

AbstractIn this work, we study the dengue dynamics with fractal-factional Caputo–Fabrizio operator. We employ real statistical data of dengue infection cases of East Java, Indonesia, from 2018 and parameterize the dengue model. The estimated basic reduction number for this dataset is$\mathcal{R}_{0}\approx2.2020$R0≈2.2020. We briefly show the stability results of the model for the case when the basic reproduction number is$\mathcal{R}_{0} <1$R0<1. We apply the fractal-fractional operator in the framework of Caputo–Fabrizio to the model and present its numerical solution by using a novel approach. The parameter values estimated for the model are used to compare with fractal-fractional operator, and we suggest that the fractal-fractional operator provides the best fitting for real cases of dengue infection when varying the values of both operators’ orders. We suggest some more graphical illustration for the model variables with various orders of fractal and fractional.
A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpatients in a tertiary teaching hospital in China
Authors: Zeng Zhangrui , Ding Yinhuan , Tian Gang , Yang Kui , Deng Jian , Li Guangrong , Liu Jinbo 
Published: August 2020

Abstract
Background
There are no current national estimates of the candidaemia burden in China, and epidemiological candidaemia data from the underdeveloped region of China are lacking.

Methods
A 7-year retrospective study was carried out to analyse the prevalence, species distribution, antifungal susceptibility, risk factors and inpatient mortality of candidaemia among paediatric and adult patients in a regional tertiary teaching hospital in China.

Results
During the seven-year study period, a total of 201 inpatients with candidaemia were identified. The median age of the patients was 65 years (range, 1 day to 92 years), and 114 of the patients (56.7%) were male. The mean annual incidence of candidaemia was 0.26 cases per 1000 admissions (0.42 cases per 1000 paediatric admissions vs 0.24 cases per 1000 adult admissions, P < 0.05). Candida albicans was the most common fungal species (81/201, 40.3%) in all patients, Candida glabrata was the most common fungal species (18/35, 51.4%) in paediatric patients. Most isolates were susceptible to flucytosine (99.0%) and amphotericin B (99.0%), and the activity of antifungal agents against Candida species was no significant difference in satisfaction between paediatric and adult patients (P > 0.05). The all-cause mortality rate was 20.4% (paediatric patients: 11.4% vs adult patients:22.3%, P > 0.05). Fewer univariate predictors of poor outcomes were identified for paediatric patients than for adult patients (4 vs 11 predictors). Respiratory dysfunction and septic shock were independent predictors of 30-day mortality for all patients.

Conclusions
The epidemiological data of candidaemia in paediatric and adult patients are only different in the distributions of Candida species and the mean annual incidence of candidaemia. Flucytosine and amphotericin B can be used as first-choice agents when no antifungal susceptibility test results are available.
Rapid determination of S-(+)-linalool in leaf of Cinnamomum osmophloeum ct. linalool using ultrasound-assisted microextraction
Authors: Chang Ting-Kuang , Lin Chun-Ya , Chen Ying-Ju , Yeh Ting-Feng , Chang Shang-Tzen 
Published: August 2020

AbstractCinnamomum osmophloeum ct. linalool is one chemotype of indigenous cinnamon in Taiwan. Its leaf essential oil (LEO) and main component S-(+)-linalool both possess great anxiolytic activities. The aim of this study was to establish ultrasound-assisted microextraction (UAME) for extracting LEO from C. osmophloeum ct. linalool. The absolute content of S-(+)-linalool and chemical composition of LEO were analyzed using GC-MS and GC-FID. To obtain the optimal conditions for UAME, four parameters (ultrasonic extraction duration, power of ultrasound, times of extraction, and leaf weight of extraction) were investigated according to the S-(+)-linalool content extracted. Results showed that the optimal condition was 10 mg of leaf extracted using n-hexane in an ultrasonicator with ultrasonic power of 80 W for 1 min. Furthermore, the absolute content of S-(+)-linalool obtained by UAME (28.3 ± 0.5 mg/g leaf) was comparable with that extracted by the 30-min hydrodistillation (HD) (26.9 ± 2.7 mg/g leaf). UAME was then employed to extract S-(+)-linalool from leaves at different stages of maturity (young, semi-mature, and mature). Results indicated that only mature leaf contains large amounts of S-(+)-linalool. Of note is that the LEO extracted by UAME contains coumarin, while that extracted by HD does not. Coumarin is an important ingredient in a number of cosmetic products due to its odor-fixing properties. With UAME, the leaf of C. osmophloeum ct. linalool has potential to be used as an aromatic material for further applications. In conclusion, UAME established in the present study provides a simple and rapid method for the determination of S-(+)-linalool and chemical composition of LEO from C. osmophloeum ct. linalool.