bluuebunny/crossref_metadata_2025_split huggingface dataset:
The direct and spillover effects of liner shipping connectivity on merchandise trade
Authors: Lin Pei-Chun , Kuo Szu-Yu , Chang Jui-Hung 
Published: April 2020

PurposeThis paper aims to address the following questions: is good liner shipping connectivity a requisite for merchandise imports plus exports? What is the average of merchandise imports plus exports of the countries neighboring China? Do the merchandise imports plus exports of these countries correspond to each country’s own merchandise imports plus exports or liner shipping connectivity index (LSCI)?Design/methodology/approachThe authors spatially analyze liner shipping connectivity and merchandise imports plus exports using 2016 data and a common framework for linear regression to establish the relationship amongst a country’s LSCI and its merchandise imports plus exports and between its merchandise imports plus exports and those of its neighbors. Merchandise imports plus exports of countries are not necessarily independent of each other, and countries that are contiguous may produce similar observations.FindingsNorth America and Western Europe comprised clusters of countries that participated more actively in the international trading system, while Africa’s countries had less international trade than average. The study identifies and quantifies the geographical ripple of transport infrastructure on merchandise trade from a national perspective. Notably, a spatially lagged term improved the model’s ability to account for variations in merchandise imports plus exports across countries.Originality/valueThe spatial lag of merchandise imports plus exports can contribute to specifying the spread of merchandise imports plus exports beyond what the authors would anticipate from a country’s network of liner shipping.
The impact of collaborative decision-making on logistics service performance for container shipping services
Authors: Lai Po-Lin , Su Dong-Taur , Tai Hui-Huang , Yang Ching-Chiao 
Published: April 2020

Purpose
The increasing demand for high-quality logistics services has forced container shipping firms to decrease logistics service failure to retain the customers. This study thus aims to apply organizational information processing theory (OIPT) to construct a maritime supply chain collaborative decision-making model and examine its impact on logistics service performance.

Design/methodology/approach
In total, 142 usable questionnaires were collected from questionnaire survey. A two-step structural equation modeling approach including confirmatory factor analysis was subsequently performed to test the hypotheses.

Findings
The results show that internal information integration positively impacts external information integration, that external information integration positively impacts collaborative decision-making, and that collaborative decision-making positively impacts logistics service performance for container shipping firms. However, a relationship between internal information integration and collaborative decision-making was not found in this study.

Research limitations/implications
This study primarily examines collaborative decision-making from the view of container shipping firms. Future research including other supply chain members is needed to generalize the results and could also incorporate other factors such as relationship quality and culture, into the model to address this issue.

Practical implications
To decrease the occurrence of logistics failures and improve service quality in the maritime logistics process, it is suggested that container shipping firms apply information technology for acquiring and assimilating logistics information internally and externally across the supply chain to facilitate decision-making.

Originality/value
This study contributes to the knowledge about the antecedents and impacts of collaborative decision-making for container shipping firms in Taiwan. Particularly, in line with OITP, the findings indicate that container shipping firms can facilitate logistics decision-making and strategy formulation through information integration, which in turn enhances logistics service performance.
Fixed combination of tazarotene and betamethasone dipropionate for treatment of psoriasis vulgaris: The result of a phase 3, multicenter, randomized controlled trial
Authors: Chen Hao , Sun Jianfang , Yang Haizhen , Sun Qiuning , Zhang Jianzhong , Gu Jun , Wen Hai , Li Ming , Liu Xiaoming , Yang Huilan , Lou Donghua 
Published: April 2020

AbstractLong‐term use of corticosteroids or local use of tazarotene (TAZ) alone for the treatment of psoriasis cause safety issues and low compliance rates. Combining these two may optimize their efficacy and minimize safety concerns. This study aimed to evaluate the clinical efficacy and safety of a fixed combination of TAZ 0.05% and betamethasone dipropionate 0.05% (BM) for psoriasis vulgaris. A multicenter, randomized, single‐blinded, controlled phase 3 clinical trial was conducted. A total of 600 Chinese subjects with psoriasis vulgaris were randomized (3:1:1) to TAZ/BM cream, TAZ gel or BM cream groups for 6 weeks with an 8‐week follow up. The primary efficacy assessment end‐point was 75% improvement in Psoriasis Area and Severity Index (PASI‐75) at 6 weeks. Secondary outcome assessments included PASI‐90, percentage of PASI decrease and so forth. Safety and treatment‐related adverse events were monitored throughout the study. Our results demonstrated that the TAZ/BM group exhibited statistically significant superiority in PASI‐75 over TAZ (6.74% vs 1.67%) within 2 weeks. After 6 weeks of treatment, PASI‐75 was 44.94% in the TAZ/BM group while 19.17% and 35.00% in the TAZ and BM group, respectively. At the 8‐week follow up, the relapse rate of the TAZ/BM group was significantly lower than the BM group (10.62% vs 29.63%, P = 0.0269) though comparable with the TAZ group (10.00%). The most frequently reported treatment‐related adverse event was mild to moderate level of skin irritation events. TAZ/BM combination has significant advantages over TAZ, including satisfying efficacy, rapid onset and reduced local stimulation. Meanwhile, compared with BM, it has the advantages of longer relief time and reduced clinical relapse rate. The TAZ/BM combination drug provides psoriatic patients an alternative drug with high efficacy and low relapse rate and safety concerns.
More ethical, more innovative? The effects of ethical culture and ethical leadership on realized innovation
Authors: Van der Wal Zeger , Demircioglu Mehmet Akif 
Published: April 2020

AbstractAre ethical public organisations more likely to realize innovation? The public administration literature is ambiguous about this relationship, with evidence being largely anecdotal and focused mainly on the ethical implications of business‐like behaviour and positive deviance, rather than how ethical behaviour and culture may contribute to innovation. In this paper we examine the effects of ethical culture and ethical leadership on reported realized innovation, using 2017 survey data from the Australia Public Service Commission (n = 80,316). Our findings show that both ethical culture at the working group‐level and agency‐level as well as ethical leadership have significant positive associations with realized innovation in working groups. The findings are robust across agency, work location, job level, tenure, education, and gender and across different samples. We conclude our paper with theoretical and practical implications of our research findings.
Fentanyl Detection Using Eosin Y Paper Assays,
Authors: Canfield Jeremy R. , Agarwal Sandip , Fortener Samuel K. , Sprague Jon E. 
Published: April 2020

AbstractEosin Y is a potential new color test for use in detecting illicit drugs that has not been extensively studied. In the present study, a variety of drugs of abuse and fentanyl analogues were tested to determine which drugs will bind to eosin Y, which functional groups are capable of binding and eliciting a color change, and a mechanism for eosin Y binding to fentanyl. Further, these agents were combined with common cutting agents and other drugs of abuse in order to determine the fentanyl detection limit in a drug mixture using an eosin Y test strip. Additionally, cobalt thiocyanate was used to determine whether the combination of cobalt thiocyanate and eosin Y has the potential to identify fentanyl. Through the testing performed, we concluded that (i) Eosin Y is capable of detecting low amounts of fentanyl down to 1%, (ii) Eosin Y binds to select tertiary amines to produce an orange to pink color change, and (iii) Eosin Y binds to the nonpiperidine ring nitrogen of fentanyl as a primary binding site and the piperidine ring nitrogen as a secondary binding site. While the cobalt thiocyanate assay detected 1% fentanyl in some of the mixtures, eosin Y detected 1% fentanyl in all mixtures. Finally, eosin Y was able to detect fentanyl in forensic case samples containing heroin and various cutting agents. Based on our results, eosin Y has the potential to screen for fentanyl and fentanyl analogues and can detect fentanyl in low amounts when mixed with common cutting agents.
Utility of Postmortem Vitreous Beta‐Hydroxybutyrate Testing for Distinguishing Sudden from Prolonged Deaths and for Diagnosing Ketoacidosis
Authors: Klaric Kristina‐Ana , Milroy Christopher M. , Parai Jacqueline L. 
Published: April 2020

AbstractA retrospective, cross‐sectional analysis of vitreous beta‐hydroxybutyrate (BHB) on 967 forensic cases over a two‐year period was conducted. Cases were sorted into six categories of death: (i) sudden traumatic/non‐natural (ST), (ii) sudden natural (SN), (iii) prolonged traumatic/non‐natural (PT), (iv) prolonged natural (PN), (v) diabetic ketoacidosis (DKA), and (vi) alcoholic ketoacidosis (AKA). The mean BHB for all cases was 1.67 mmol/L (17.4 mg/dL; range: 0.11–18.02 mmol/L). The numbers of DKA, AKA, PN, PT, SN, and ST deaths were 21, 5, 155, 258, 275, and 253, respectively. Their mean vitreous BHBs were as follows: 11.04 mmol/L (DKA), 8.88 mmol/L (AKA), 1.56 mmol/L (PN), 1.55 mmol/L (PT), 1.26 mmol/L (SN), and 1.38 mmol/L (ST). There was a statistically significant difference between the mean BHBs of the PN and SN death groups (p < 0.001), as well as between those of the PT and ST death groups (p = 0.004). Given the overlapping ranges seen between the prolonged and sudden death groups, the identified differences did not hold clinical significance. In addition, we sought to determine a threshold value for vitreous BHB to definitely diagnose cases of ketoacidosis. BHB threshold concentrations between 2.5 and 5 mmol/L produced sensitivities >92% and specificities >96%. A receiver operator characteristic curve found 3.43 mmol/L to be the optimal cutoff value, demonstrating a specificity of 98.3% and a sensitivity of 96.2%.
Children and adolescents with severe acute behavioural disturbance in the emergency department
Authors: Carison Anna , Babl Franz E , Hill Ashley , O'Donnell Sinead M 
Published: April 2020

AbstractObjectiveMental health (MH) presentations to ED are increasing in children and adolescents. Little is known about patients with severe acute behavioural disturbance (ABD). We set out to describe patients with ABD severe enough to trigger an acute crisis team response in ED (termed ‘Code Grey’) and how they differ from other MH patients.MethodsRetrospective electronic medical record review of all ED patients with MH discharge codes at a tertiary children's hospital. We assessed the epidemiology and management of patients who triggered acute crisis team interventions (Code Grey) as proxy for severe ABD. We calculated the odds ratios (ORs with 95% confidence intervals) of key demographic factors compared to other MH patients.ResultsDuring 2018, there were 85 347 ED presentations of which 1695 (2.0%) were related to MH diagnoses; 84 MH patients had 141 MH presentations triggering 204 Code Greys (26 patients triggered 59% of Code Greys). These patients had higher triage acuity (OR 12.6 [8.3–19.0]), stayed longer in ED (>12 h OR 8.2 [5.1–13.1]) and were more likely to be admitted (OR 2.0 [1.4–3.0]) compared with non‐Code Grey MH presentations. Patients were physically (19.2%), mechanically (31.9%) or chemically restrained (37.6%). Eight different medication approaches were used as either a single agent or a combination of oral and/or intramuscular agents.ConclusionsChildren and adolescents with severe ABD differ from other MH presentations and often require physical or chemical restraint. Anticipatory management plans may be valuable for repeat presenters.
Seroepidemiology of hepatitis E virus infection in patients undergoing maintenance hemodialysis: Systematic review and meta‐analysis
Authors: Tavakoli Ahmad , Alavian Seyed Moayed , Moghoofei Mohsen , Mostafaei Shayan , Abbasi Aida , Farahmand Mohammad 
Published: April 2020

AbstractPatients undergoing regular hemodialysis (HD) are at an extreme risk of acquiring bloodstream infections compared to the general population. Hepatitis E virus (HEV) infection is an important emerging health issue in these patients. To date, numerous studies have investigated the seroprevalence of HEV among HD patients across the world; however, the data are conflicting. The present study aimed to measure the exposure rate of HD patients to HEV infection by estimating the overall seroprevalence of HEV in this high‐risk group. A systematic literature search was carried out using five electronic databases from inception to January 10, 2020, with standard keywords. Pooled seroprevalence estimates with 95% confidence intervals (CIs) were calculated using a random intercept logistic regression model. The seroprevalence of HEV increased from 6.6% between the years of 1994 and 2000 to 11.13% from 2016 to 2020. Blood transfusion was associated with a nearly 2‐fold increase in the rate of HEV seropositivity (OR = 1.99; 95% CI: 1.50‐2.63, P < .0001, I2 = 6.5%). HEV seroprevalence among patients with HD for more than 60 months was significantly higher than those with HD for less than 60 months (27.69%, 95% CI: 20.69%‐35.99% vs 15.78%, 95%CI: 8.85%‐26.57%, respectively) (P = .06). Our results indicated increased exposure of HD patients with HEV infection over the last decade. We concluded that blood transfusion and duration of HD are considerable risk factors for acquiring HEV infection among HD patients.
Condition‐dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis)
Authors: Wei Huamao , Tian Yuanyong , Lin Yumeng , Maeda Hayato , Yamashita Tetsuro , Yu Kefeng , Takaki Koichi , Yuan Chunhong 
Published: April 2020

AbstractThe purpose of this study was to confirm inosine monophosphate (IMP) generation and to clarify the decomposition pathway of adenosine monophosphate (AMP) by investigating the properties of AMP, IMP, and adenosine (AdR) decomposition enzymes in Japanese scallop (Patinopecten yessoensis). The results showed that IMP accumulated due to AMP decomposition via endogenous enzymes in scallops stored at both 4 °C and 20 °C. The AMP decomposition rate was highest in the supernatant of homogenized scallop adductor muscle, followed by the suspended solution and precipitate, while IMP could not be decomposed in scallop. The results indicated that the activity of AdR deaminase was very high, and this enzyme was involved in an intracellular process in scallop. Moreover, 1 min of heating exerted little influence on the AMP and AdR decomposition rates, while 5 min of heating induced enzyme denaturation. The IMP generation rate increased dramatically in scallop crude enzyme solution containing 5 mM ethylenediaminetetraacetic acid (EDTA). This suggests that the major pathway of AMP decomposition might change with variations in metal ion concentrations in Japanese scallop.Practical ApplicationIMP generation in Japanese scallop (Patinopecten yessoensis) caused by endogenous enzymes was confirmed. IMP is very important for the umami taste (a pleasant savory taste) of aquatic products. As IMP accumulation might be achieved by changing the concentration of divalent metal ions and no IMP 5’‐nucleotidase activity was detected in scallop, a suitable process to produce good flavor scallops with high IMP contents might be developed.
Breaking Gridlock: How Path Dependent Layering Enhances Resilience in Global Trade Governance
Authors: Faude Benjamin 
Published: April 2020

AbstractWhat are the implications of the proliferating preferential trade agreements (PTAs) for the liberal trade order? Many scholars and practitioners see large increases in PTAs as a destabilizing factor that undermines core features of the post‐war international trade system. By contrast, this paper argues that the accelerated growth of PTAs since the mid‐1990s enhances the resilience of the liberal trade order. PTAs increase the ability of the order to accommodate heterogeneous preferences and distributive conflicts. They represent a continuation of a longer path of liberalization set in motion by the General Agreement on Tariffs and Trade (GATT). This path‐dependent development created conditions for a gradual expansion of the membership and the regulatory scope of the GATT/WTO system, but also heightened levels of preference heterogeneity and distributive conflicts. By enabling groups of states with homogenous preferences to layer new rules on top of the multilateral GATT/WTO system, PTAs enable the continuation of the liberalization path. Consequently, PTAs have served as complements rather than to undermine the WTO.
Epithelioid hemangioendothelioma of the sternum
Authors: Song Wenpeng , Zhen Zeng , Li Lin , Ye Jing , Zhou Sicheng , Wu Qiyou , Xu Liu , Li Huilin , Lin Feng 
Published: April 2020

AbstractEpithelioid hemangioendothelioma (EHE) is a rare vascular tumor composed of dendritic and endothelial cells, and accounts for less than 1% of all vascular tumors. The tumor may arise from any location in the body, but it has a predilection for veins of the extremities, the liver, bone, and skin. Herein, we report a case of a 43‐year‐old man who presented with a chest mass accompanied by chest pain. Computed tomography (CT) scan of the chest showed a 3 cm × 2 cm sternal mass in the chest wall. We performed tumor resection and reconstruction of the chest wall. EHE was confirmed via postoperative pathology. The patient underwent postoperative adjuvant radiotherapy, and no evidence of tumor recurrence was discovered during the one‐year follow up.
Trifluridine/tipiracil: A practical guide to its use in the management of refractory metastatic colorectal cancer in Australia
Authors: Price Timothy , Burge Matthew , Chantrill Lorraine , Gibbs Peter , Pavlakis Nick , Shapiro Jeremy , Sjoquist Katrin 
Published: April 2020

AbstractTrifluridine/tipiracil is available on the Australian Pharmaceutical Benefits Scheme for the treatment of patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, fluoropyrimidine‐, oxaliplatin‐ and irinotecan‐based chemotherapies, anti‐vascular endothelial growth factor agents and anti‐epidermal growth factor receptor agents. This article reviews trifluridine/tipiracil clinical data and presents practical information on its use in the management of refractory mCRC in Australia. Whereas the primary mechanism of action of fluoropyrimidines such as fluorouracil (5‐FU) and capecitabine is enzyme inhibition of nucleotide synthesis, trifluridine/tipiracil primarily acts by incorporation into DNA, resulting in DNA dysfunction. Trifluridine/tipiracil has activity in patients with 5‐FU‐resistant tumors and can be considered in patients with prior intolerance or toxicity to 5‐FU. In the pivotal phase III RECOURSE trial evaluating trifluridine/tipiracil in chemotherapy‐refractory mCRC, efficacy benefits were observed across all a priori prognostic subgroups including those defined by age (≥65 and ≥75 years), geographical origin, primary tumor site or KRAS status. Trifluridine/tipiracil therapy benefits appropriately selected patients who have an ECOG performance status of 0 or 1, with no more than mild hepatic impairment or mild‐to‐moderate renal impairment, and who are capable of adhering to oral therapy safely. Appropriate dosing, monitoring for adverse events and effective management of side effects are essential.
Outcomes of video‐assisted thoracoscopic surgery lobectomy in septuagenarians
Authors: Fong Laura S. , Ko Viktor , Mclaughlin Aden , Okiwelu Ngozichukwuka Louis , Newman Mark A. , Passage Jurgen , Sanders Lucas H. A. , Joshi Pragnesh V. 
Published: April 2020

AbstractBackgroundSpread of technology and increased surveillance have led to more patients with lung cancers being identified than ever before. Increasingly, patients from the elderly population are referred for surgery; however, many studies do not focus on this patient group. We reviewed the outcomes of septuagenarians who underwent lobectomy via an open thoracotomy (OT) or video‐assisted thoracoscopic surgery (VATS) approach to determine whether the VATS approach would result in superior post‐operative outcomes.MethodsBetween January 2010 and June 2016, a total of 96 patients aged 70 years or older underwent a lobectomy for non‐small cell lung carcinoma. Patients who underwent resection for metastatic disease, small cell lung cancer or neuroendocrine tumour were excluded. Demographic details, early and late post‐operative outcomes including post‐operative arrhythmia, myocardial infarction, respiratory failure, cerebrovascular events, infection, prolonged air leak, delirium, readmission and 30‐day mortality were studied. Mean follow‐up duration was 23 ± 19.1 months.ResultsSeventy‐five patients underwent lobectomy via a VATS approach and 21 patients underwent lobectomy via an OT approach. There was no 30‐day mortality and no difference in overall survival between the two techniques (P = 0.25). There was no significant difference between the two techniques with regard to post‐operative stroke, myocardial infarction, atrial fibrillation, pneumonia, delirium or bronchopleural fistula. VATS patients had a significantly shorter mean hospital length of stay (VATS 4.7 days, OT 9.3 days, P = 0.005).ConclusionSeptuagenarians with non‐small cell lung carcinoma can successfully undergo curative lung resection with a low incidence of post‐operative complications.
Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease
Authors: Noomuna Panae , Risinger Mary , Zhou Sitong , Seu Katie , Man Yuncheng , An Ran , Sheik Daniel A. , Wan Jiandi , Little Jane A. , Gurkan Umut A. , Turrini Francesco M. , Kalfa Theodosia , Low Philip S. 
Published: April 2020

SummaryMany hypotheses have been proposed to explain how a glutamate to valine substitution in sickle haemoglobin (HbS) can cause sickle cell disease (SCD). We propose and document a new mechanism in which elevated tyrosine phosphorylation of Band 3 initiates sequelae that cause vaso‐occlusion and the symptoms of SCD. In this mechanism, denaturation of HbS and release of heme generate intracellular oxidants which cause inhibition of erythrocyte tyrosine phosphatases, thus permitting constitutive tyrosine phosphorylation of Band 3. This phosphorylation in turn induces dissociation of the spectrin‐actin cytoskeleton from the membrane, leading to membrane weakening, discharge of membrane‐derived microparticles (which initiate the coagulation cascade) and release of cell‐free HbS (which consumes nitric oxide) and activates the endothelium to express adhesion receptors). These processes promote vaso‐occlusive events which cause SCD. We further show that inhibitors of Syk tyrosine kinase block Band 3 tyrosine phosphorylation, prevent release of cell‐free Hb, inhibit discharge of membrane‐derived microparticles, increase sickle cell deformability, reduce sickle cell adhesion to human endothelial cells, and enhance sickle cell flow through microcapillaries. In view of reports that imatinib (a Syk inhibitor) successfully treats symptoms of sickle cell disease, we suggest that Syk tyrosine kinase inhibitors warrant repurposing as potential treatments for SCD.