bluuebunny/crossref_metadata_2025_split huggingface dataset:
OS DESAFIOS DA GESTÃO DA INOVAÇÃO EM ORGANIZAÇÕES HOSPITALARES
Authors: Sousa Josiano 
Published: January 2021

- Objetivo: Este artigo tem por objetivo identificar os principais desafios gerenciais para a implantação de inovações em organizações hospitalares.
- Método: Sua elaboração se deu por meio de uma abordagem qualitativa com método hipotético dedutivo através de uma revisão bibliográfica e o software VOSviewer foi utilizado para construção de tabelas e mapas conceituais.
- Fundamentação teórica: A literatura apresenta vários conceitos para o termo inovação, entre os quais pode ser apresentado o conceito seminal defendido por Schumpeter (1942) e, de maneira mais contemporânea autores como Blanch et al, (2014) e Candido, (2018), têm se dedicado a estudar o tema, porém, embora tenha havido um aumento das publicações sobre o tema inovação, a maioria das abordagens encontradas na literatura ainda exploram o tema relacionando-o ao setor de manufatura.
- Resultados: o artigo destaca que a implantação de inovações deve ser enxergada como um processo que requer o aprendizado de novos padrões e competências e que, entre os principais desafios gerenciais estão: a necessidade de desenvolver um ecossistema devidamente alinhado, envolvido e comprometido com a implantação de práticas inovadoras; envolver os gerentes de nível médio no processo de inovação; promover uma integração entre os elos internos e externos; desenvolver um método de gestão capaz de explorar as habilidades conjuntas da empresa e dos stakeholders e desenvolver uma filosofia de empresa inovadora no setor de saúde, pois a capacidade de inovar está relacionada à postura da gestão estratégica exercida na organização.
- Conclusões/contribuições: O artigo apresenta contribuições acadêmicas e gerenciais. As contribuições acadêmicas são observadas ao elaborar um framework conceitual sobre os principais desafios gerencias para a implantação de inovações em organizações hospitalares. Já as contribuições gerenciais fornecem aos gestores um conjunto de pontos de atenção que, se devidamente observados, poderão contribuir para minimizar as possíveis barreiras presentes quando da implantação de inovações em organizações hospitalares. Por fim, o artigo apresenta suas limitações e as recomendações para a realização de futuras pesquisas.
Platelet-Rich and Platelet-Poor Plasma Might Play Supportive Roles in Cancer Cell Culture: A Replacement for Fetal Bovine Serum?
Authors: Talebi Mehdi , Vatanmakanian Mousa , Mirzaei Ali , Barfar Yaghoub , Hemmatzadeh Maryam , Nahayati Milad A. , Velaei Kobra , Hosseinzadeh Asghar , Yazdanpanah Behruz , Yahyavi Yahya , Azimi Ako , Rahmani Mina , Heydarabad Milad Z. 
Published: January 2021

Background:
Platelet-Rich (PRP) and Platelet-Poor plasma (PPP) are widely used in research and
clinical platforms mainly due to their capacities to enhance cell growth. Although the short half-life (5 days)
and the high price of platelet products pose challenges regarding their usage, they maintain the growth regulatory
functions for weeks. Thus, we aimed to assess the supplementary values of these products in human CCRF-
CEM cancer cells. Mechanistically, we also checked if the PRP/PPP treatment enhances YKL-40 expression
as a known protein regulating cell growth.

Methods:
The PRP/PPP was prepared from healthy donors using manual stepwise centrifugation and phase separation.
The viability of the cells treated with gradient PRP/PPP concentrations (2, 5, 10, and 15%) was measured
by the MTT assay. The YKL-40 mRNA and protein levels were assessed using qRT-PCR and western
blotting. The data were compared to FBS-treated cells.

Result:
Our findings revealed that the cells treated by PRP/PPP not only were morphologically comparable to
those treated by FBS but also showed greater viability at the concentrations of 10 and 15%. Moreover, it was
shown that PRP/PPP induce cell culture support, at least in part, via inducing YKL-40 expression at both mRNA
and protein levels in a time- and dose-dependent manner.

Conclusion:
Collectively, by showing cell culture support comparable to FBS, the PRP/PPP might be used as
good candidates to supplement the cancer cell culture and overcome concerns regarding the use of FBS as a
non-human source in human cancer research.
Virtual Private Network Flow Detection in Wireless Sensor Networks Using Machine Learning Techniques
Authors: Praveen Surapaneni Phani , Krishna Thati Bala Murali , Chawla Sunil Kumar , Anuradha Chokka 
Published: January 2021

Background:
Every organization generally uses a VPN service individually to bypass the
filters that hide the actual communication. Such communication filtration is not allowed by the organizational
monitoring network. But these institutes are not in a position to spend a considerable amount of
funds on a secure sockets layer to monitor traffic flow over their computer networks.

Objective:
Our work suggests a simple technique to block or detect annoying VPN clients inside the
network activities. This method does not require the network to decrypt or even decode any network
communication.

Methods:
The proposed solution selects two machine learning techniques Feature Tree and K-means as
classification techniques that work on time-related features. First, the DNS mapping with the ordinary
characteristic of the transmission control protocol / Internet protocol computer the network stack is
identified, and it is not to be considered as a regular traffic flow if the domain name information is not
available. The process not only examines non-standard utilization of hypertext transfer protocol security
but also conceals such communication from hypertext transfer protocol security dependent filters in the
firewall to detect as an anomaly in large.

Results:
We define the traffic flow as normal traffic flow and VPN traffic flow. These two flows are
characterized by taking two machine learning techniques, Feature Tree and K-means. We executed each
experiment 4 times. As a result, eight types of regular traffics and eight types of VPN traffics were represented.

Conclusion:
Once the traffic flow is identified, it is classified and studied by machine learning techniques.
Using time-related features, the traffic flow is defined as normal flow or VPN traffic flow.
Effect of Internet-Based Rehabilitation Programs on Improvement of Pain and Physical Function in Patients with Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Xie Su-Hang , Wang Qian , Wang Li-Qiong , Wang Lin , Song Kang-Ping , He Cheng-Qi 
Published: January 2021

Background
Osteoarthritis (OA) is a chronic, debilitating, and degenerative joint disease. However, it is difficult for patients with knee OA to access conventional rehabilitation when discharging from the hospital. Internet-based rehabilitation is one of the promising telemedicine strategies to provide a means combining monitoring, guidance, and treatment for patients with knee OA.

Objective
The aim of this study was to conduct a systematic review and meta-analysis for assessing the effect of internet-based rehabilitation programs on pain and physical function in patients with knee OA.

Methods
Keywords related to knee OA and internet-based rehabilitation were systematically searched in the Web of Science, MEDLINE, EMBASE, CENTRAL, Scopus, PEDro (Physiotherapy Evidence Database), CNKI, SinoMed, and WANFANG databases from January 2000 to April 2020. Only randomized controlled trials were included. The authors independently screened the literature. The main outcome measures were focused on pain and physical function. A meta-analysis was performed on the collected data. Review Manager (RevMan, version 5.3) was used for all analyses.

Results
The systematic review identified 6 randomized controlled trials, 4 of which were included in the meta-analysis, comprising a total of 791 patients with knee OA. The meta-analysis with the fixed-effects model showed that the internet-based rehabilitation programs could significantly alleviate the osteoarthritic pain for patients compared with conventional rehabilitation (standardized mean difference [SMD] –0.21, 95% CI  −0.4 to –0.01, P=.04). No significant difference was found in the improvement of physical function in patients with knee OA compared with conventional rehabilitation within 2 to 12 months (SMD –0.08, 95% CI −0.27 to 0.12, P=.43).

Conclusions
This systematic review shows that internet-based rehabilitation programs could improve the pain but not physical function for patients with knee OA. However, there was a very small number of studies that could be included in the review and meta-analysis. Thus, further studies with large sample sizes are warranted to promote the effectiveness of internet-based rehabilitation and to develop its personalized design.
Uji Perbandingan Antibiotik Profilaksis Ceftriaxone versus Cefazolin pada Bedah Obstetri dan Ginekologi
Authors: Rahayu Asri , Rahmawati Fita , Andayani Tri Murti , Siradjuddin Ammar 
Published: January 2021

Surgical site infection (SSI) is the most common complication in postoperative surgical patients which is associated with high morbidity, mortality, and cost burden. These complications can be prevented by giving proper prophylactic antibiotics. Cefazolin is a recommended prophylactic antibiotic, but in the practice in Indonesia hospital, there are still many uses of ceftriaxone. This study aimed to compare the clinical outcome and safety of cefazolin and ceftriaxone as prophylactic antibiotics in preventing SSI in obstetric and gynecological surgical patients. The study design was double-blind randomized controlled trial. The data collection was conducted from January to June 2020 at dr. Dradjat Prawiranegara Regional Hospital Serang. A total of 82 subjects who met the inclusion criteria were divided into two groups by block randomization, 41 subjects were given cefazolin and 41 subjects were given ceftriaxone. The clinical outcome was measured by preventing SSI for the effectiveness and side effects for safety outcomes in both groups. The comparison of effectiveness and side effects were analyzed using the bivariate test (chi-square or fisher’s exact test) and relative risk (RR). The study showed that the effectiveness of cefazolin was the same as ceftriaxone in preventing SSI for 30 days (RR= 0.89; p= 0.724; 95%CI: 0,193-3,133) with the number of SSI 12.2% vs 9.8%. Side effects included nausea, vomiting, and phlebitis was observed in the administration of antibiotic by intravenous push (IVP) pre-operating. Cefazolin have safetier than ceftriaxone with the incidence of side effects were 9.8% vs 29.3% ((RR = 0,33; p= 0.003; 95% CI: 0.076-0.895). Cefazolin is an antibiotic recommended by Indonesian Ministry of Health and the Association of Obstetrics and Gynecology. This study encourages the use of cefazolin to prevent resistance due to ceftriaxone to overuse.
Bosquejo para una historia estructural de la aceleración capitalista
Authors: Cristiano Javier Luis 
Published: January 2021

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Entre los análisis de la transformación de las estructuras temporales de la modernidad la idea de aceleración ocupa un lugar prominente, donde el trabajo de Hartmut Rosa es la refe- rencia principal, pues ha esbozado una teoría sistemática en donde la aceleración se conecta con variables explicativas conformando una tendencia sociológicamente discernible. El objetivo de este artículo es profundizar ese análisis, puntualmente en la conexión que Rosa establece entre aceleración y capitalismo. A fin de analizar ese vínculo como un movimiento tendencial de la sociedad moderna, se procede, primer, a precisar las relaciones formales entre la lógica del capital, tal como fue analizada por Marx, y la aceleración de concretos y fundamentales procesos sociales. Después, se trata de mostrar el modo en que esas relaciones lógicas se han desplegado en la historia larga del capitalismo, apelando para ello a conceptos y a material empírico proveniente de la escuela francesa de la regulación. Con ello se obtiene un bosquejo de historia estructural de la aceleración que, además de precisar y desarrollar con medios no </span>habituales la teoría de Rosa, tiene valor poten- cial para análisis históricos y conceptuales más específicos.</p></div></div></div>
Identification of Primary Container of Aedes Mosquitoes Breeding Site in Urban Region of Dengue Endemic Area, Purwokerto Indonesia
Authors: Wijayanti Siwi Pramatama Mars , Octaviana Devi , Nurlaela Sri 
Published: January 2021

Dengue prevention and control more reliant on reducing its vector, Aedes sp. mosquitoes by mosquito breeding nest eradication method. Therefore, identification of the primary container of the Aedes sp. breeding site particularly in the urban region of dengue-endemic area is a crucial effort to conduct an effective dengue prevention program. This research aimed to identify the primary container of the Aedes sp. breeding site in the urban region of the dengue-endemic area. This is a descriptive cross-sectional study, located in an urban region of dengue-endemic area within Banyumas Regency of Central Java Indonesia. A total of 300 houses in three urban areas were observed in urban areas of Purwokerto namely Arcawinangun, Purwanegara, and Karangpucung (100 houses each area). A total of 1504 water-holding containers were observed. All container was observed and recorded the type, color, lid condition, position, and the presence of mosquito larvae. The analysis was conducted by calculating the percentage of types, color, lid condition, and position of the container also the presence of mosquito larvae. The result of this study highlighted that flower pots and bathtubs were the primary types of containers with Aedes sp. larvae in the urban area. The characteristics of larvae-positive containers mostly open, bright, and located indoor position. Dengue prevention efforts by targeting the primary types of containers for mosquito breeding are expected to reduce the adult mosquito population.
Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don)
Authors: Fadhli Haiyul , Ikhtiarudin Ihsan , Lestari Putri 
Published: January 2021

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50 of 327,01µg/mL.
The Problems and Alternative Solutions for the Implementation of Entrepreneurship Education in the Higher Education: A Literature Review
Authors: Adnan Gunawan , Lailatussaadah Lailatussaadah , Bin Jamil Asyraf Isyraqy , Jannah Misbahul , Muslim Buhori , Erfiati Erfiati 
Published: January 2021

This study aimed to find some problems in implementing entrepreneurship education at higher education (university). The method used in this study was the literature review by searching articles on electronics journal database. The databases used in this study were Jstor, Sage, Proquest, Elsevier, Emerald, Insight, Springer Plus, and Google Scholars from 2003 to October 2019. Fifteen articles were found using five keywords: entrepreneurship education, entrepreneurial, unemployment, job seeker, and job creator. The data were analyzed by collecting the related articles, reducing them based on the topic discussion, displaying the data, and concluding. It was found that there were some problems faced during the implementation of entrepreneurship education. Thus, it can be concluded that the bigger the problem in the implementation of entrepreneurship education, the more extensive necessitate for the alternative formula. It is urged that further studies be conducted to expose more detailed comparisons between the problems found within the country and abroad. This action is considered as the foundation of a better service.
Mathematics courseware for dyscalculia students (MCDYs)
Authors: Noordin Muhamad Shazrie Suhaidi , Mohd Bahrin Ummu Fatihah , Hamzah Siti Salbiah , Sa’dan Siti ‘Aisyah 
Published: January 2021

MCDys is a courseware created as a learning tool for students with dyscalculia. The syllabus is developed based on the Linus module that is provided by the Kementerian Pendidikan Malaysia (KPM). Dyscalculia is a term used for learners that have a disability in learning mathematics. In developing this courseware, ADDIE model is used. ADDIE is a framework that many instructional designers and developers use to develop the courses. There are five stages in ADDIE Model which are analysis, design, development, implementation, and evaluation. To design the interface, Schneiderman's eight golden rules of interface design is used. Schneiderman's eight golden rules include striving for consistency, enabling frequent users to use shortcuts, offering informative feedback, designing dialogue to yield closure, offering simple error handling, permitting easy reversal of actions, supporting internal locus of control and reducing short-term memory load. The content of the courseware uses interactive approaches such as video, animation, and quizzes, and game-based activities to encourage users’ understanding and grab their attention. User evaluation and expert evaluation were conducted to test the effectiveness and acceptance of the interface, usability, activity, navigation, multimedia, sound, image, text, animation, and video. The results show that the courseware has the highest score for usability score with a mean of 4.6(SD=0.55). For future enhancement, more animation will be explored to suit the dyscalculia students’ learning.
Keywords: courseware, Dyscalculia, ADDIE Model, Mathematics, Schneiderman’s
The role of social media orientation to improve relationship quality and innovation performance in SME’s
Authors: Damayanti Adelia Ika , Adhiatma Ardian 
Published: January 2021

This study aims to determine how the role of social media orientation towards the quality of relationships and innovation performance through sharing or gathering knowledge between organizations in SMEs. The rise of the use of social media is an attraction for SMEs to look for in maintaining good relations with stakeholders. With easy access and extensive networks, social media will be able to have a positive and beneficial impact on SMEs. Therefore, social media can play a role in inter organizational knowledge sharing about SMEs to produce good relationship quality with customers and other SMEs that are industrially based on their value congruence which will improve SMEs innovation performance. Data obtained from 109 SMEs owners in Indonesia with the criteria of using digital technology (social media) as a business tool and has been operating for 1 year. Data collection was carried out using a questionnaire which was further analysed using Partial Least Square (PLS). The results showed that there was a positive and significant influence on social media orientation on inter organizational knowledge sharing while inter organizational knowledge sharing had a positive and significant effect on relationship quality and innovation performance, and value congruence could also moderate the relationship between inter organizational knowledge sharing and relationship quality.
Keywords: Social Media Orientation, Inter Organizational Knowledge Sharing, Value Congruence, Relationship Quality, Innovation Performance
PERSEPSI GURU SENIOR TERHADAP PEMBELAJARAN TEMATIK PADA PENDIDIKAN ANAK USIA DINI DI SALATIGA
Authors: Sopacua Eleonora Esther Debora , Rahardjo Maria Melita 
Published: January 2021

Penelitian ini bertujuan untuk menggali persepsi guru-guru senior terhadap pembelajaran tematik dalam pendidikan anak usia dini. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan pendekatan fenomenologi. Data yang digunakan dalam penelitian ini adalah data primer persepsi guru-guru senior mengenai pembelajaran tematik. Instrumen yang digunakan untuk pengambilan data adalah pedoman wawancara, dokumen RPPH, dan catatan observasi. Data yang terkumpul dianalisis dengan menggunakan analisis fenomenologi interpretatif. Hasil dari penelitian menunjukkan bahwa, pertama, guru-guru senior mempunyai persepsi bahwa pembelajaran tematik bukan hal yang baru didalam PAUD dan tematik adalah ciri khas dari pembelajaran di PAUD. Kedua, guru-guru senior mempersepsi bahwa pembelajaran tematik yang sekarang lebih banyak menggunakan benda nyata. Guru-guru senior mencampuradukkan konsep pembelajaran tematik dengan pendekatan saintifik. Ketiga, para guru mempersepsikan bahwa student-centered merupakan ciri khas pembelajaran tematik yang sekarang. Namun, pada prakteknya mereka belum sepenuhnya dapat menerapkannya dalam pembelajaran. Dengan demikian, pembelajaran tematik dipersepsi guru sebagai pendekatan pembelajaran yang sudah lama mereka ketahui tetapi pada prakteknya mereka belum mempersepsikan dan mempraktekan pembelajaran tematik sebagaimana mestinya.
This research aimed to obtain senior teachers’ perception about thematic learning in early childhood education. The method used in this research was descriptive qualitative with phenomenology research paradigm. The data used in this research was the primary data of teachers’ perception about thematic learning. Instrument used to collect the data were guided interview, lesson plans, and observation notes. Data analysis was performed by using interpretative phenomenology analysis. The results showed that, first, the senior teachers perceived that thematic learning was not a new issue in early childhood education. Further, they perceived thematic learning was one of the characteristics of the early childhood education. Second, they perceived the current thematic learning in terms of real objects presence. They mixed the concept of thematic learning with scientific approach. Third, they perceived that student-centered is one of the characteristics of current thematic learning. Nonetheless, they remained unable to accordingly apply it in learning. In summary, thematic learning have been perceived by teachers as a learning approach, however, they have not perceived and practiced it in learning properly.