bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELSA in Industrial Robotics
Authors: Studley Matthew , Winfield Alan 
Published: August 2020

AbstractPurpose of ReviewIndustry is changing; converging technologies allow a fourth Industrial Revolution, where it is envisaged that robots will work alongside humans. We investigate how the research community is responding to the ethical, legal, and social aspects of industrial robots, with a primary focus on manufacturing industry.Recent FindingsThe literature shows considerable interest in the impact of robotics and automation on industry. This interest spans many disciplines, which is to be expected given that the ELS impacts of industrial robotics may be profound in their depth and far-reaching in their scope.SummaryWe suggest that the increasing importance of human-robot interaction (HRI) reduces the differentiation between industrial robotics and other robotic domains and that the main challenges to successful adoption for the benefit of human life are above all political and economic. Emerging standards and legal frameworks may scaffold this success, but it is apparent that getting it wrong might have repercussions that last for generations.
The Many Deaths of the Last ‘Abbāsid Caliph al-Musta‘ṣim bi-llāh (d. 1258)
Authors: NEGGAZ NASSIMA 
Published: August 2020

AbstractThe death of the last ‘Abbāsid Caliph al-Musta‘ṣim bi-llāh (d. 1258) has been the object of contradictory historical accounts by medieval historians both in the East and the West. Was he put to death by starvation? Did he have melted gold poured down his throat? Was he executed by Hülegü's own hands, or even by a Georgian Prince? Was he rolled in a carpet and kicked to death, hanged, or strangled? Writers of the period offer colourful portrayals of this event. Some saw it as martyrdom, others as a humiliating death preceded by moral admonishment and blame by Hülegü. Building upon earlier studies, this article offers a comprehensive view of the extant sources on the topic produced both in the Abode of Islam and Western Europe, as well as in Armenia and Georgia. Rather than seeking the “facts” behind the accounts, this article adopts a literary-critical and socio-political approach, arguing that the accounts are replete with symbolism targeting their specific audiences, and that the choices made by the historians on the manner of the Caliph's death were meant to offer commentary on—and evaluation of—‘Abbāsid rule.
Native Acts, Immigrant Acts: Citizenship, Naturalization, and the Performance of Civic Identity during the Progressive Era
Authors: Stanciu Cristina 
Published: August 2020

AbstractThis article reveals the complicity of immigration restriction laws and federal Indian policy with organized Americanization in legislating an imagined, desirable “new American” at the beginning of the twentieth century, when resurgent nationalism threatened to restrict undesirable immigrants as it also sought to assimilate Indigenous people into a mass of Americanism. While the immigrant has figured in the U.S. national imaginary as someone whodesiresAmerica, the American Indian was notdesiredto enter into political membership—although Native land was desired, and subsequently taken by settlers through strategies of dispossession written into federal Indian law. This essay argues that theIndian—read as an imagined category with little connection to the lives ofNativepeople—occupies an anomalous position in the legal history of naturalization, finalized with the passing of the Indian Citizenship Act in 1924, at the same time that racist immigration restriction quotas also limited the entrance of new immigrants into the United States through the 1924 Johnson-Reed Immigration Act. For Native people, Americanization and the imposition of citizenship were extensions of colonialism, adding one civic status over another—domestic dependent, ward, or U.S. citizen. For new immigrants hailing from southern and eastern Europe, forced by economic and cultural constraints to relocate to the United States, in contrast to their Anglo-Saxon or Nordic settler predecessors, Americanization meant a renunciation of political allegiance to other sovereigns, the acquisition of English, and civic education for citizenship. This essay challenges the myth of America as a “nation of immigrants,” and the settler colonial nation-state's ongoing infatuation with its colonial project as it continues to erase Indigenous presence and sovereignty.
Double Whammy: Why the Underrepresentation of Women among Workplace and Political Decision Makers Matters in Pandemic Times
Authors: Brooks Deborah Jordan , Saad Lydia 
Published: August 2020

AbstractIn this article, we explore whether women's underrepresentation among political and workplace decision makers may subject female citizens and employees to COVID-19-related decisions that are at odds with their preferences. We find that women overall, as well as female political party members, workers, and workplace leaders in particular, share a distinctively female perspective that more heavily emphasizes caution with respect to COVID-19 compared with men. Given the limited representation of women leaders across most industries and in politics, COVID-19 regulations are thus likely to be less cautious than would be the case if there were an equitable representation of women across leadership roles. We argue that female employees, in particular, face a representational “double whammy” for COVID-19: gender imbalances in workplace leadership create inequities that are compounded—rather than redressed—by unequal political representation. We conclude by addressing how this dynamic may enhance the movement of women away from Republican candidates moving forward.
Beyond the COVID-19 pandemic: ‘Learning the hard way’ – adapting long-term IAPT service provision using lessons from past outbreaks
Authors: Skilbeck Lilian , Spanton Christopher , Roylance Ian 
Published: August 2020

Abstract
Infectious disease outbreaks have occurred sporadically over the centuries. The most significant ones of this century, as reported by the World Health Organization, include the EVD epidemic, SARS pandemic, Swine Flu pandemic and MERS pandemic. The long-term mental health consequences of outbreaks are as profound as physical ones and can last for years post-outbreak. This highlights the need for enhancing the preparedness of pragmatic mental health service provision. Due to its magnitude, the novel COVID-19 pandemic has proven to be the most impactful. Compared with previous outbreaks, COVID-19 has also occurred at higher rates in frontline staff in addition to patients. As COVID-19 is more contagious than earlier outbreaks, there is a need to identify infected people quickly and isolate them and their contacts. This is the current context in which mental health services including IAPT have had to operate. Evidently, Improving Access to Psychological Therapies (IAPT) services are a major mental health service provider in the UK that have demonstrated variability in their response to COVID-19. While some IAPT services quickly adapted their existing strengths and resources (e.g. remote working), other services were less prepared. To date, there are no clear unitary guidelines on how IAPT services can use their pre-existing resources to respond to the long-term effects of outbreaks. In light of this, the current paper aims to reflect on the lessons learned from past outbreaks in order to consider how an enhanced remit of IAPT might integrate with other services to meet the long-term needs of patients and staff affected by COVID-19.

Key learning aims

(1)
To understand the development of IAPT within the NHS mental health services.

(2)
To understand the nature of past outbreaks and COVID-19.

(3)
To reflect on lessons from past outbreaks in order to understand how IAPT can respond to the long-term effects of COVID-19.
Effective two-pass herbicide programs to control glyphosate-resistant Palmer amaranth (Amaranthus palmeri) in glyphosate/dicamba-resistant soybean
Authors: Kumar Vipan , Liu Rui , Peterson Dallas E. , Stahlman Phillip W. 
Published: August 2020

AbstractField experiments were conducted in 2018 and 2019 at Kansas State University Ashland Bottoms (KSU-AB) research farm near Manhattan, KS, and Kansas State University Agricultural Research Center (KSU-ARC) near Hays, KS, to determine the effectiveness of various PRE-applied herbicide premixes and tank mixtures alone or followed by (fb) an early POST (EPOST) treatment of glyphosate + dicamba for controlling glyphosate-resistant (GR) Palmer amaranth in glyphosate/dicamba-resistant (GDR) soybean. In experiment 1, PRE-applied sulfentrazone + S-metolachlor, saflufenacil + imazethapyr + pyroxasulfone, chlorimuron + flumioxazin + pyroxasulfone, and metribuzin + flumioxazin + imazethapyr provided 85% to 94% end-of-season control of GR Palmer amaranth across both sites. In comparison, Palmer amaranth control ranged from 63% to 87% at final evaluation with PRE-applied pyroxasulfone + sulfentrazone, pyroxasulfone + sulfentrazone plus metribuzin, pyroxasulfone + sulfentrazone plus carfentrazone + sulfentrazone, and sulfentrazone + metribuzin at the KSU-ARC site in experiment 2. All PRE fb EPOST (i.e., two-pass) programs provided near-complete (98% to 100%) control of GR Palmer amaranth at both sites. PRE-alone programs reduced Palmer amaranth shoot biomass by 35% to 76% in experiment 1 at both sites, whereas all two-pass programs prevented Palmer amaranth biomass production. No differences in soybean yields were observed among tested programs in experiment 1 at KSU-ARC site; however, PRE-alone sulfentrazone + S-metolachlor, saflufenacil + imazethapyr + pyroxasulfone, and chlorimuron + flumioxazin + pyroxasulfone had lower grain yield (average, 4,342 kg ha−1) compared with the top yielding (4,832 kg ha−1) treatment at the KSU-AB site. PRE-applied sulfentrazone + metribuzin had a lower soybean yield (1,776 kg ha−1) compared with all other programs in experiment 2 at the KSU-ARC site. These results suggest growers should proactively adopt effective PRE-applied premixes fb EPOST programs evaluated in this study to reduce selection pressure from multiple POST dicamba applications for GR Palmer amaranth control in GDR soybean.
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo
Authors: Ma Yarui , Zhu Qing , Liang Junbo , Li Yifei , Li Mo , Zhang Ying , Wang Xiaobing , Zeng Yixin , Jiao Yuchen 
Published: August 2020

AbstractLaboratory research and pharmacoepidemiology provide support for metformin as a potential antitumor agent. However, the lack of a clear understanding of the indications of metformin limits its efficacy. Here, we performed a genome-wide CRISPR knockout negative screen to identify potential targets that might synergize with metformin. Next-generation sequencing of pooled genomic DNAs isolated from surviving cells after 18 days of metformin treatment (T18) compared to those of the untreated cells at day 0 (T0) yielded candidate genes. Knockdown of a group of cyclin-dependent kinases (CDKs), including CDK1, CDK4, and CDK6, confirmed the results of the screen. Combination treatment of the CDKs inhibitor abemaciclib with metformin profoundly inhibited tumor viability in vitro and in vivo. Although cell cycle parameters were not further altered under the combination treatment, investigation of the metabolome revealed significant changes in cell metabolism, especially with regard to fatty acid oxidation, the tricarboxylic acid cycle and aspartate metabolism. Such changes appeared to be mediated through inhibition of the mTOR pathway. Collectively, our study suggests that the combination of CDKs inhibitor with metformin could be recognized as a potential therapy in future clinical applications.
LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling
Authors: Kim Hyunjung , Park Sung-Hyo , Han Song Yee , Lee Yun-Sil , Cho Jaeho , Kim Jin-Mo 
Published: August 2020

AbstractRadiation therapy is an important modality in the treatment of lung cancer, but it can lead to radiation pneumonitis, and eventually radiation fibrosis. To date, only few available drugs can effectively manage radiation-induced pulmonary fibrosis. Lipoxins are endogenous molecules exhibit anti-inflammatory and pro-resolving effects. These molecules play a vital role in reducing excessive tissue injury and chronic inflammation; however, their effects on radiation-induced lung injury (RILI) are unknown. In this study, we investigated the effects of lipoxin A4 (LXA4) on RILI using our specialized small-animal model of RILI following focal-ablative lung irradiation (IR). LXA4 significantly inhibited immune-cell recruitment and reduced IR-induced expression of pro-inflammatory cytokines and fibrotic proteins in the lung lesion sites. In addition, micro-CT revealed that LXA4 reduced IR-induced increases in lung consolidation volume. The flexiVentTM assays showed that LXA4 significantly reversed IR-induced lung function damage. Moreover, LXA4 downregulated the activities of NF-κB and the Smad-binding element promoters. The expression of FPR2, an LXA4 receptor, increased during the development of IR-induced pulmonary fibrosis, whereas silencing of endogenous LXA4 using an antagonist (WRW4) or FPR2 siRNA resulted in impaired development of pulmonary fibrosis in response to IR. Collectively, these data suggest that LXA4 could serve as a potent therapeutic agent for alleviating RILI.
MICAL2 is essential for myogenic lineage commitment
Authors: Giarratana Nefele , Conti Filippo , La Rovere Rita , Gijsbers Rik , Carai Paolo , Duelen Robin , Vervliet Tim , Bultynck Geert , Ronzoni Flavio , Piciotti Roberto , Costamagna Domiziana , Fulle Stefania , Barravecchia Ivana , Angeloni Debora , Torrente Yvan , Sampaolesi Maurilio 
Published: August 2020

AbstractContractile myofiber units are mainly composed of thick myosin and thin actin (F-actin) filaments. F-Actin interacts with Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 (MICAL2). Indeed, MICAL2 modifies actin subunits and promotes actin filament turnover by severing them and preventing repolymerization. In this study, we found that MICAL2 increases during myogenic differentiation of adult and pluripotent stem cells (PSCs) towards skeletal, smooth and cardiac muscle cells and localizes in the nucleus of acute and chronic regenerating muscle fibers. In vivo delivery of Cas9–Mical2 guide RNA complexes results in muscle actin defects and demonstrates that MICAL2 is essential for skeletal muscle homeostasis and functionality. Conversely, MICAL2 upregulation shows a positive impact on skeletal and cardiac muscle commitments. Taken together these data demonstrate that modulations of MICAL2 have an impact on muscle filament dynamics and its fine-tuned balance is essential for the regeneration of muscle tissues.
Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury
Authors: Sada Naoki , Fujita Yuki , Mizuta Nanano , Ueno Masaki , Furukawa Takahisa , Yamashita Toshihide 
Published: August 2020

AbstractBrain injury causes serious motor, sensory, and cognitive disabilities. Accumulating evidence has demonstrated that histone deacetylase (HDAC) inhibitors exert neuroprotective effects against various insults to the central nervous system (CNS). In this study, we investigated the effects of the HDAC inhibition on the expression of brain-derived neurotrophic factor (BDNF) and functional recovery after traumatic brain injury (TBI) in mice. Administration of class I HDAC inhibitor increased the number of synaptic boutons in rewiring corticospinal fibers and improved the recovery of motor functions after TBI. Immunohistochemistry results showed that HDAC2 is mainly expressed in the neurons of the mouse spinal cord under normal conditions. After TBI, HDAC2 expression was increased in the spinal cord after 35 days, whereas BDNF expression was decreased after 42 days. Administration of CI-994 increased BDNF expression after TBI. Knockdown of HDAC2 elevated H4K5ac enrichment at the BDNF promoter, which was decreased following TBI. Together, our findings suggest that HDAC inhibition increases expression of neurotrophic factors, and promote neuronal rewiring and functional recovery following TBI.
Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
Authors: Rai Shinya , Tanaka Hirokazu , Suzuki Mai , Espinoza J. Luis , Kumode Takahiro , Tanimura Akira , Yokota Takafumi , Oritani Kenji , Watanabe Toshio , Kanakura Yuzuru , Matsumura Itaru 
Published: August 2020

AbstractMutated receptor tyrosine kinases (MT-RTKs) such as internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3 ITD) and a point mutation KIT D816V are driver mutations for acute myeloid leukemia (AML). Clathrin assembly lymphoid myeloid leukemia protein (CALM) regulates intracellular transport of RTKs, however, the precise role for MT-RTKs remains elusive. We here show that CALM knock down leads to severely impaired FLT3 ITD- or KIT D814V-dependent cell growth compared to marginal influence on wild-type FLT3- or KIT-mediated cell growth. An antipsychotic drug chlorpromazine (CPZ) suppresses the growth of primary AML samples, and human CD34+CD38- AML cells including AML initiating cells with MT-RTKs in vitro and in vivo. Mechanistically, CPZ reduces CALM protein at post transcriptional level and perturbs the intracellular localization of MT-RTKs, thereby blocking their signaling. Our study presents a therapeutic strategy for AML with MT-RTKs by altering the intracellular localization of MT-RTKs using CPZ.
Petahertz non-linear current in a centrosymmetric organic superconductor
Authors: Kawakami Y. , Amano T. , Ohashi H. , Itoh H. , Nakamura Y. , Kishida H. , Sasaki T. , Kawaguchi G. , Yamamoto H. M. , Yamamoto K. , Ishihara S. , Yonemitsu K. , Iwai S. 
Published: August 2020

AbstractCharge acceleration during an intense light field application to solids attracts much attention as elementary processes in high-harmonic generation and photoelectron emission. For manipulating such attosecond dynamics of charge, carrier-envelope-phase (CEP: relative phase between carrier oscillation of light field and its envelope function) control has been employed in insulators, nanometal and graphene. In superconducting materials, collective control of charge motion is expected because of its strongly coherent nature of quasi-particles. Here we report that, in a layered organic superconductor, a non-linear petahertz current driven by a single-cycle 6 femtosecond near infrared field shows up as second harmonic generation (SHG), which is in contrast to the common belief that even harmonics are forbidden in the centrosymmetric system. The SHG represents a CEP sensitive nature and an enhancement near the superconducting temperature. The result and its quantum many-body analysis indicate that a polarized current is induced by non-linear acceleration of charge, which is amplified by superconducting fluctuations. This will lead to petahertz functions of superconductors and of strongly correlated systems.
Influenza A virus is transmissible via aerosolized fomites
Authors: Asadi Sima , Gaaloul ben Hnia Nassima , Barre Ramya S. , Wexler Anthony S. , Ristenpart William D. , Bouvier Nicole M. 
Published: August 2020

AbstractInfluenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.
Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana
Authors: Hanemian Mathieu , Vasseur François , Marchadier Elodie , Gilbault Elodie , Bresson Justine , Gy Isabelle , Violle Cyrille , Loudet Olivier 
Published: August 2020

AbstractInvestigating the evolution of complex phenotypes and the underlying molecular bases of their variation is critical to understand how organisms adapt to their environment. Applying classical quantitative genetics on a segregating population derived from a Can-0xCol-0 cross, we identify the MADS-box transcription factor FLOWERING LOCUS M (FLM) as a player of the phenotypic variation in plant growth and color. We show that allelic variation at FLM modulates plant growth strategy along the leaf economics spectrum, a trade-off between resource acquisition and resource conservation, observable across thousands of plant species. Functional differences at FLM rely on a single intronic substitution, disturbing transcript splicing and leading to the accumulation of non-functional FLM transcripts. Associations between this substitution and phenotypic and climatic data across Arabidopsis natural populations, show how noncoding genetic variation at a single gene might be adaptive through pleiotropic effects.
Femtosecond X-ray emission study of the spin cross-over dynamics in haem proteins
Authors: Kinschel Dominik , Bacellar Camila , Cannelli Oliviero , Sorokin Boris , Katayama Tetsuo , Mancini Giulia F. , Rouxel Jérémy R. , Obara Yuki , Nishitani Junichi , Ito Hironori , Ito Terumasa , Kurahashi Naoya , Higashimura Chika , Kudo Shotaro , Keane Theo , Lima Frederico A. , Gawelda Wojciech , Zalden Peter , Schulz Sebastian , Budarz James M. , Khakhulin Dmitry , Galler Andreas , Bressler Christian , Milne Christopher J. , Penfold Thomas , Yabashi Makina , Suzuki Toshinori , Misawa Kazuhiko , Chergui Majed 
Published: August 2020

AbstractIn haemoglobin the change from the low-spin (LS) hexacoordinated haem to the high spin (HS, S = 2) pentacoordinated domed deoxy-myoglobin (deoxyMb) form upon ligand detachment from the haem and the reverse process upon ligand binding are what ultimately drives the respiratory function. Here we probe them in the case of Myoglobin-NO (MbNO) using element- and spin-sensitive femtosecond Fe Kα and Kβ X-ray emission spectroscopy at an X-ray free-electron laser (FEL). We find that the change from the LS (S = 1/2) MbNO to the HS haem occurs in ~800 fs, and that it proceeds via an intermediate (S = 1) spin state. We also show that upon NO recombination, the return to the planar MbNO ground state is an electronic relaxation from HS to LS taking place in ~30 ps. Thus, the entire ligand dissociation-recombination cycle in MbNO is a spin cross-over followed by a reverse spin cross-over process.