bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute liver dysfunction with delayed peak of serum aminotransferase levels as a presentation of ornithine transcarbamylase deficiency in females
Authors: Clarkston Kathryn , Lee Joy , Donoghue Sarah , Peters Heidi , Eiroa Hernan , Shah Amit A. , Loomes Kathleen , Wen Jessica , Oliver Mark , Hardikar Winita , Prada Carlos E. , Asai Akihiro 
Published: December 2020

AbstractWe describe 10 females with ornithine transcarbamylase (OTC) deficiency and liver dysfunction, revealing a unique pattern of hepatocyte injury in which initial hyperammonemia and coagulopathy is followed by a delayed peak in aminotransferase levels. None of the patients required urgent liver transplantation, though five eventually underwent transplant for recurrent metabolic crises. We intend that this novel observation will initiate further investigations into the pathophysiology of liver dysfunction in OTC‐deficient patients, and ultimately lead to the development of therapies and prevent the need for liver transplant.
n‐Type Rigid Semiconducting Polymers Bearing Oligo(Ethylene Glycol) Side Chains for High‐Performance Organic Electrochemical Transistors
Authors: Chen Xingxing , Marks Adam , Paulsen Bryan D. , Wu Ruiheng , Rashid Reem B. , Chen Hu , Alsufyani Maryam , Rivnay Jonathan , McCulloch Iain 
Published: December 2020

AbstractN‐type conjugated polymers as the semiconducting component of organic electrochemical transistors (OECTs) are still undeveloped with respect to their p‐type counterparts. Herein, we report two rigid n‐type conjugated polymers bearing oligo(ethylene glycol) (OEG) side chains, PgNaN and PgNgN, which demonstrated an essentially torsion‐free π‐conjugated backbone. The planarity and electron‐deficient rigid structures enable the resulting polymers to achieve high electron mobility in an OECT device of up to the 10−3 cm2 V−1 s−1 range, with a deep‐lying LUMO energy level lower than −4.0 eV. Prominently, the polymers exhibited a high device performance with a maximum dimensionally normalized transconductance of 0.212 S cm−1 and the product of charge‐carrier mobility μ and volumetric capacitance C* of 0.662±0.113 F cm−1 V−1 s−1, which are among the highest in n‐type conjugated polymers reported to date. Moreover, the polymers are synthesized via a metal‐free aldol‐condensation polymerization, which is beneficial to their application in bioelectronics.
Hydrogen‐Bonding Assisted Catalytic Kinetic Resolution of Acyclic β‐Hydroxy Amides
Authors: Porey Arka , Mondal Bhaskar Deb , Guin Joyram 
Published: December 2020

AbstractEnantioenriched acyclic α‐substituted β‐hydroxy amides are valuable compounds in chemical, material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alcohol with N‐heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.
Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment
Authors: Fang Xiao , Cai Shuxian , Wang Min , Chen Zhaowei , Lu Chunhua , Yang Huanghao 
Published: December 2020

AbstractNitric oxide (NO) is a gaseous signal molecule with multiple physiological functions, and it also plays a key role in cancer therapy. However, the production of NO which depends on O2 or H2O2 is limited within the tumor microenvironment, leading to unsatisfactory anticancer effect. Herein, we report a NO‐based phototherapeutic strategy mediated by photogenerated holes for hypoxic tumors, which is achieved by irradiation of the poly‐L‐arginine modified carbon‐dots‐doped graphitic carbon nitride nanomaterial (ArgCCN). Upon red light irradiation, the photogenerated holes on ArgCCN oxidized water into H2O2 which subsequently oxidized the arginine residues to produce NO. In vitro and in vivo experiments showed that the high concentration of NO produced by ArgCCN could induce cancer cell apoptosis. The presented phototherapeutic strategy is based on microenvironment‐independent photogenerated holes mediated oxidation reaction, paving the way for the development of NO therapeutic strategy.
Die Wechselwirkung mit ribosomalen Proteinen begleitet die Stressinduktion des Wirkstoffkandidaten BOLD‐100/KP1339 im endoplasmatischen Retikulum
Authors: Neuditschko Benjamin , Legin Anton A. , Baier Dina , Schintlmeister Arno , Reipert Siegfried , Wagner Michael , Keppler Bernhard K. , Berger Walter , Meier‐Menches Samuel M. , Gerner Christopher 
Published: December 2020

AbstractDer metallhaltige Wirkstoff BOLD‐100/KP1339 zeigte bereits vielversprechende Resultate in verschiedenen In vitro‐ und In vivo‐Tumormodellen sowie in klinischen Studien. Der detaillierte Wirkmechanismus wurde jedoch noch nicht komplett aufgeklärt. Als entscheidende Wirkstoffeffekte kristallisierten sich kürzlich die Stressinduktion im endoplasmatischen Retikulum (ER) und die damit einhergehende Modulierung von HSPA5 (GRP78) heraus. Das spontane und stabile Addukt zwischen BOLD‐100 und menschlichem Serumalbumin wurde als Immobilisierungsstrategie ausgewählt, um einen chemoproteomischen Ansatz auszuführen, der die ribosomalen Proteine RPL10, RPL24 und den Transkriptionsfaktor GTF2I als potentielle Interaktoren dieser Ru(III)‐Verbindung identifizierten. Dieses Ergebnis wurde mit proteomischen und transkriptomischen Profiling‐Experimenten kombiniert, was die Interpretation einer ribosomalen Beeinträchtigung sowie der Induktion von ER‐Stress unterstützte. Die Bildung von Polyribosomen und begleitende ER‐Schwellungen in behandelten Krebszellen wurden zudem durch TEM‐Messungen bestätigt. Somit scheint eine direkte Wechselwirkung von BOLD‐100 mit ribosomalen Proteinen die ER‐Stressinduktion und die Modulierung von GRP78 in Krebszellen zu begleiten.
Multi‐Talented Gallaphosphene for Ga−P−Ga Heteroallyl Cation Generation, CO2 Storage, and C(sp3)−H Bond Activation
Authors: Sharma Mahendra K. , Wölper Christoph , Haberhauer Gebhard , Schulz Stephan 
Published: December 2020

AbstractGallaphosphene L(Cl)GaPGaL (2; L=HC[C(Me)N(2,6‐i‐Pr2C6H3)]2), which is synthesized by reaction of LGa(Cl)PCO (1) with LGa, reacts with [Na(OCP)(dioxane)2.5] to LGa(OCP)PGaL (3), whereas chloride abstraction with LiBArF4 yields [LGaPGaL][BArF4] (4; BArF4=B(C6F5)4). 4 represents a heteronuclear analog of the allyl cation according to quantum chemical calculations. Remarkably, 2 reversibly reacts with CO2 to yield L(Cl)Ga−P[μ‐C(O)O]2GaL (5), while reactions with acetophenone and acetone selectively give compounds 6 and 7 by C(sp3)−H bond activation.
Apparent Kinetics of Co‐Gasification of Biomass and Vacuum Gas Oil (VGO)
Authors: Al‐Attas Tareq A. , Lucky Rahima A. , Hossain Mohammad M. 
Published: December 2020

AbstractThis communication reports the beneficial effects of co‐gasification of biomass and residual oil to produce syngas. In this regard, various blends of glucose (a biomass surrogate) to vacuum gas oil (VGO) have been employed to investigate the synergic effects on the gasification process. The non‐isothermal co‐gasification experiments were conducted in a thermogravimetric analyzer at different heating rates and gasifying agents. The analysis showed that the co‐gasification rate increased with the increase of glucose content in the feedstock. The presence of the oxygen in the biomass molecules helped the overall gasification process. The maximum gasification rate of 42.70 wt/min (DTGmax) was observed with 25 wt% glucose containing sample. The use of gasifying agents appeared to have some influence, especially during high temperature gasification of the glucose‐VGO blends. At a same gasification temperature, the co‐gasification rate of glucose‐VGO blends were found to be 125.7 wt/min and 98.59 wt%/min for N2 and CO2, respectively. The kinetics of the co‐gasification of glucose‐VGO blends was conducted based on modified random pore model using TGA experimental data and implemented in MATLAB. The estimated activation energy and rate constants were found to be consistent to the observed co‐gasification rates. The apparent activation energies of co‐gasification of VGO/biomass blends with different weight percentages shows values ranging 60.56–48.25 kJ/mol. The kinetics analysis suggested that the addition of biomass helped to increase the reaction rate by lowering the activation energy required for accomplishing the reactions compared with petroleum carbonaceous feedstocks. The reaction rate constants isotherms are plotted to show that the k‐values are exhibiting similar trends at moderate heating rates between 20 and 60 °C/min. This remark arises due to the nature of the reactions involved which are considered to be inherently similar in this range of heating rate.
Cloning, expression, and characterization of a novel sericin‐like protein
Authors: Bostan Fatmanur , Surmeli Nur Basak 
Published: December 2020

AbstractSilk consists of two proteins called fibroin and sericin. While fibroin is used in the textile industry and has various biomaterial applications, sericin has been considered as waste material until recently. Sericin is a multicomponent protein and it has important properties such as biocompatibility, biodegradability, cryoprotectivity, and antioxidant. Sericin from silkworm cocoons can be obtained by chemical, enzymatic, and heat treatment methods. However, sericin obtained with these treatment methods is not of consistent and high quality. Moreover, the exposure of sericin to harsh conditions during extraction leads to inconsistencies in the composition and structure of the sericin obtained. The inconsistencies in sericin structure and composition decrease application of sericin as a biomaterial. Here, we produce a sericin‐like protein (Ser4mer) with native sequence of sericin encoding four repeats of the conserved 38 amino acid motif recombinantly in Escherichia coli and characterize its structural properties. Ser4mer protein shows similar structure to native sericin and higher solubility than previously obtained recombinant sericin‐like proteins. Recombinant production of a soluble sericin‐like protein will significantly expand its applications as a biomaterial. In addition, recombinant production of silk proteins will allow us to understand sequence–structure relationships in these proteins.
The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers
Authors: Chukwueke Chidera C. , Kowalczyk William J. , Gendy Marie , Taylor Richard , Tyndale Rachel F. , Le Foll Bernard , Heishman Stephen J. 
Published: December 2020

AbstractIntroductionThe cannabinoid CB1 receptor (CB1R) has been shown in preclinical studies to be involved in nicotine reinforcement and relapse‐like behavior. The common single nucleotide polymorphism (SNP) rs2023239 may code for an alternative CB1R protein, alter CB1R expression, and be involved in nicotine dependence. To date, no study has explored the relationship between this SNP in CB1R and specific phenotypes of nicotine dependence.MethodsThe current study investigated the influence of CB1R rs2023239 in nicotine reinforcement and craving in regular cigarette smokers. Current smokers (n = 104, cigarettes per day ≥ 10) were genetically grouped (C allele group vs. No C allele group) and underwent laboratory measures of nicotine reinforcement and smoking cue‐elicited craving. Nicotine reinforcement was assessed using a forced choice paradigm, while a cue‐reactivity procedure measured cue‐elicited craving.ResultsThese results show that smokers with the C allele variant (CC + CT genotypes) experienced a lower nicotine reinforcement effect compared to those without the C allele (TT genotype). These results were similar in both our subjective and behavioral reinforcement measures, though the subjective effects did not withstand controlling for race. There was no difference between genotype groups with respect to cue‐elicited craving, suggesting a lack of influence in cue reactivity.ConclusionTaken together, these results suggest that the variation in the CB1R (i.e., rs2023239 SNP) may play a larger role in nicotine reinforcement compared to cue reactivity. This work provides impetus to further understand the physiological mechanisms that explain how CB1Rs influence nicotine dependence phenotypes.
Peptide Vectors Carry Pyrene to Cell Organelles Allowing Real‐Time Quantification of Free Radicals in Mitochondria by Time‐Resolved Fluorescence Microscopy
Authors: Wawi Mohamad Jamal , Bijoux Amandine , Inguimbert Nicolas , Mahler Christoph , Wagner Stephan , Marder Todd B. , Ribou Anne‐Cécile 
Published: December 2020

AbstractReal‐time quantification of reactive nitrogen and oxygen species (ROS) in cells is of paramount importance as they are essential for cellular functions. Their excessive formation contributes to the dysfunction of cells and organisms, ultimately leading to cell death. As ROS are mostly produced in the mitochondria, we have synthesized a fluorescent probe able to reach this organelle to detect and quantify, in real time, the variation of ROS by time‐resolved microfluorimetry. The new probes are based on the long fluorescence lifetime of pyrene butyric acid (PBA). Two PBA isomers, attached at their 1‐ or 2‐positions to a peptide vector to target mitochondria, were compared and were shown to allow the measurement of free radical species and oxygen, but not non‐radical species such as H2O2.
Venous bullet embolism to the right ventricle: Case report and review of management
Authors: Henderson Luke , Wachsman Ashley , Chikwe Joanna , Esmailian Fardad 
Published: December 2020

AbstractIntravascular missile emboli to the right heart should be retrieved surgically if the risk of surgical complication due to sternotomy and cardiotomy is low. Endovascular retrieval is another possible method of extraction to be considered.
Burkitt lymphoma in children causing an osteolytic lesion in the mandible: A case report
Authors: De Coninck Wouter , Govaerts Dries , Bila Michel , Vansteenkiste Griet , Uyttebroeck Anne , Tousseyn Thomas , Politis Constantinus 
Published: December 2020

AbstractImaging is the first step in diagnosing a persistent swelling of the jaw. A lymphoma in the jaw typically manifests as a poorly defined osteolytic lesion. A biopsy is mandatory and will result in definite diagnosis.
Preparation and physical‐biological characterization on titanium doped fluorophosphate nanobioglass: Bone implants
Authors: Sankaralingam Pugalanthi Pandian , Sakthivel Poornimadevi , Andinadar Subbiah Priscilla , Rahumathulla Jenifabegum , Chinnaswamy Thangavel Vijayakumar 
Published: December 2020

AbstractIn bone tissue repair, metallic implants like screws, pins, plates, stents are considered as boon for patients but it has the disadvantage of being a foreign body and can never get absorbed or get converted to bone. These metallic implants serve the purpose often temporarily, but it fails to attain the mechanical, elastic properties near to that of the normal human bones. To circumvent these drawbacks, the preparation of nanobioglasses having titanium and different proportions of fluoride using melt quenching method is reported. The physical, thermal, and elastic properties of the materials were characterized by their densities, thermal transitions, and elastic moduli by ultrasonic study. The in vitro degradation and bioactivity of these nanobioglasses were assessed by immersion in simulated body fluid (SBF). The hydroxyapatite(HAp) formation was assessed by the variation in pH over 21 days and its presence was confirmed by FTIR, XRD, SEM, and EDS. Human osteo sarcoma MG‐63(ATCC‐1427), SAOS‐2(ATCC‐85), and gastric adenocarcinoma (AGS)(ATCC‐1739) cell lines were used to evaluate cytotoxicity of the bioglasses by MTT assay. The biological efficiency of titanium doped fluorophosphate enhancing bone formation was assessed by the capacity of the ionic dissolution products of the bioglasses to enhance the osteocalcin and ALP activity. The phosphate‐based titanium nanobioglasses doped with fluoride possesses elastic strength nearer to the normal human bone, higher bone bonding ability and the rate of biodegradation equaling the rate of bone formation than the commercially available bioglass.
Documenting the course of loss of control over eating prior to, during and after pregnancy among women with pre‐pregnancy overweight and obesity
Authors: Donofry Shannon D. , Emery Rebecca L. , Kolko Conlon Rachel P. , Germeroth Lisa J. , Wang Bang , Cheng Yu , Levine Michele D. 
Published: December 2020

AbstractObjectiveLoss of control over eating (LOC) is common among women, particularly those with overweight and obesity (OV/OB), and predicts weight gain. Given the importance of understanding weight and eating behaviors during pregnancy, we sought to characterize LOC across pregnancy and the postpartum period among women with pre‐pregnancy OV/OB.MethodsPregnant women (N = 257; 28.44 ± 5.48 years old) with self‐reported OV/OB prior to pregnancy were interviewed using a pregnancy‐adapted version of the Eating Disorder Examination (EDE‐PV). Pre‐pregnancy LOC was retrospectively assessed during the first trimester and then prospectively assessed monthly throughout pregnancy and postpartum over the course of seven assessments.ResultsRates of LOC were significantly higher during pregnancy compared to prior to (=44.845, p < .01) and after (=36.379, p < .01) pregnancy, with 37% (n = 95) of women reporting ≥1 LOC episode during pregnancy. LOC during pregnancy was associated with higher likelihood of LOC postpartum. Higher age (OR = 1.084, p = .04) and identifying as a minority (OR = 0.344, p = .02) was associated with greater likelihood of experiencing LOC during pregnancy only.DiscussionLOC during pregnancy is common among women with pre‐pregnancy OV/OB, suggesting that screening and intervention for LOC during pregnancy may be warranted. Future research is necessary to examine the relationship between LOC during pregnancy and maternal and infant health outcomes.
PRADOC: a trial on the efficiency of a transition care management plan for hospitalized patients with heart failure in France
Authors: Duflos Claire , Labarre Jean‐Philippe , Ologeanu Roxana , Robin Marie , Cayla Guillaume , Galinier Michel , Georger Frédéric , Petroni Thibaut , Alarcon Clément , Aguilhon Sylvain , Delonca Christine , Battistella Pascal , Agullo Audrey , Leclercq Florence , Pasquie Jean‐Luc , Papinaud Laurence , Mercier Grégoire , Ricci Jean‐Etienne , Roubille François 
Published: December 2020

AbstractAimsTransition care programmes are designed to improve coordination of care between hospital and home. For heart failure patients, meta‐analyses show a high efficacy but with moderate evidence level. Moreover, difficulties for implementation of such programmes limit their extrapolation.Methods and resultsWe designed a mixed‐method study to assess the implementation of the PRADO‐IC, a nationwide transition programme that aims to be offered to every patient with heart failure in France. This programme consists essentially in an administrative assistance to schedule follow‐up visits and in a nurse follow‐up during 2 to 6 months and aims to reduce the annual heart failure readmission rate by 30%. This study assessed three quantitative aims: the cost to avoid a readmission for heart failure within 1 year (primary aim, intended sample size 404 patients), clinical care pathways, and system economic outcomes; and two qualitative aims: perceived problems and benefits of the PRADO‐IC. All analyses will be gathered at the end of study for a joint interpretation. Strengths of this study design are the randomized controlled design, the population included in six centres with low motivation bias, the primary efficiency analysis, the secondary efficacy analyses on care pathway and clinical outcomes, and the joint qualitative analysis. Limits are the heterogeneity of centres and of intervention in a control group and parallel development of other new therapeutic interventions in this field.ConclusionsThe results of this study may help decision‐makers to support an administratively managed transition programme.
An engineering‐oriented variable water flow air‐conditioning system terminal flow rate estimation method based on component flow resistance characteristics
Authors: Zhao Tianyi , Sun Yue , Liu Zhongjie , Li Kuishan 
Published: December 2020

AbstractWater flow rate plays an important role in the modeling prediction, fault detection and diagnosis, and performance optimization of the variable water flow air‐conditioning (VWFAC) system. However, flowmeters employed by the system's terminals have not been widely used in engineering applications for the constraints in installation space and high installation and retrofit costs. Therefore, in this study, a terminal flow rate estimation method is proposed for the VWFAC system to reduce the dependency on flowmeters. The water flow rate estimation model is developed based on the flow resistance characteristics inside the air handling unit (AHU) and was trained and verified at the Monitoring and Control Laboratory established in the Dalian University of Technology. The results indicate that the maximum root‐mean‐square error (RMSE) during the training and validation sessions are 0.038 m3/h and 0.028 m3/h, respectively, while the corresponding mean absolute percentage error (MAPE) are below 1.4% and 6.5%, which is acceptable for engineering applications. To improve the flow rate estimation accuracy of the model, water temperature, water flow rate, and pressure difference are suggested to cover a wide varied range during the training session as much as possible. Systematic error is an important index in determining the demands for sensor's accuracy class. According to the results of water flow rate, the systematic errors of the estimates are ranged between 0.51% and 0.76%, only about 1/4 to 1/3 of the measurements systematic errors. Based on the error propagation theory, the water flow rate estimates would be reliable if the systematic error of the pressure measurements does not over twice that of the water flow rate measurements. This flow rate estimation method can be further applied to other thermal engineering systems to bring considerable economic benefits for engineering applications.
Selective embolization of lingual artery in transoral robotic surgery for the management of recurrent base of tongue carcinomas
Authors: Rao Vishal U. S. , Subash Anand , R. Bhargavi Vidya , Sinha Piyush , Bagadia Ritvi K. , Kudpaje Akshay , Arakeri Gururaj , Subbanna Indusekhara 
Published: December 2020

AbstractBackgroundThe incidence of oropharyngeal carcinoma has been on the rise in recent decades. About 30% of patients who undergo definitive chemoradiation as the initial treatment present with residual/recurrent disease. In such a situation, surgical salvage either in the form of traditional open surgery or transoral robotic surgery (TORS) remains a viable treatment option. However, the extensive vascular supply of the posterior tongue and tonsillar bed increases the risk of perioperative bleeding, which is a key concern. The article describes the technique of selective pre‐operative embolization to reduce the risk of perioperative bleeding and enumerate its advantages in providing a bloodless field during surgery.MethodsProspective study of 5 patients with recurrent or residual midline BOT tumours who underwent TORS after selective lingual artery embolization at our centre.Results and ConclusionsNone of the patients had any major perioperative bleeding or post procedural complications. All the patients after TORS had their tongue vascularity preserved with adequate recovery of tongue functions. Selective embolization of the feeder vessels provides a favorable bloodless surgical field without affecting the vascular integrity of the remnant tongue. This added advantage helps restoring the normal oral phase of swallowing.