bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis
Authors: Ahmed Zeeshan 
Published: October 2020

AbstractPrecision medicine aims to empower clinicians to predict the most appropriate course of action for patients with complex diseases like cancer, diabetes, cardiomyopathy, and COVID-19. With a progressive interpretation of the clinical, molecular, and genomic factors at play in diseases, more effective and personalized medical treatments are anticipated for many disorders. Understanding patient’s metabolomics and genetic make-up in conjunction with clinical data will significantly lead to determining predisposition, diagnostic, prognostic, and predictive biomarkers and paths ultimately providing optimal and personalized care for diverse, and targeted chronic and acute diseases. In clinical settings, we need to timely model clinical and multi-omics data to find statistical patterns across millions of features to identify underlying biologic pathways, modifiable risk factors, and actionable information that support early detection and prevention of complex disorders, and development of new therapies for better patient care. It is important to calculate quantitative phenotype measurements, evaluate variants in unique genes and interpret using ACMG guidelines, find frequency of pathogenic and likely pathogenic variants without disease indicators, and observe autosomal recessive carriers with a phenotype manifestation in metabolome. Next, ensuring security to reconcile noise, we need to build and train machine-learning prognostic models to meaningfully process multisource heterogeneous data to identify high-risk rare variants and make medically relevant predictions. The goal, today, is to facilitate implementation of mainstream precision medicine to improve the traditional symptom-driven practice of medicine, and allow earlier interventions using predictive diagnostics and tailoring better-personalized treatments. We strongly recommend automated implementation of cutting-edge technologies, utilizing machine learning (ML) and artificial intelligence (AI) approaches for the multimodal data aggregation, multifactor examination, development of knowledgebase of clinical predictors for decision support, and best strategies for dealing with relevant ethical issues.
Progress on the national echinococcosis control programme in China: analysis of humans and dogs population intervention during 2004–2014
Authors: Yu Qing , Xiao Ning , Han Shuai , Tian Tian , Zhou Xiao-Nong 
Published: October 2020

Abstract
Background
A national control program for echinococcosis has been in effect since 2005 in China. This program has applied a comprehensive strategy, and good control results have been achieved. Human echinococcosis prevalence rate decrease from 1.08% in 2004 to 0.24% in 2012. The objective of this study is focusing on assessment of the programme with two indices, including patient treatment and registered dogs deworming, in endemic areas of echincoccosis control over the period of 10 years (2004–2014) in China.

Methods
We established the database including demography at county and township levels with coverage for ten provinces and autonomous regions of China in this study. We using methods of epidemiological descriptive, instead the expectation-maximization for missing value filling for grouping available patients into those subjected to surgery and those receiving drug treatment after population screening and the dogs population after registered by deworming. We performed Microsoft Excel software and SPSS software on the results as percentages with the corresponding 95% confidence intervals (95% CIs). We also statistically analyzed the economics data on patient treatment and dogs deworming after the corresponding discount with annual bank interest rates (USD 1 = CNY 6.5, bank discount average changes of 2.3–3.3%).

Results
During 2004–2014, the grant total average rate of surgical patient (after surgical operation) treatment had increased with 32.4% and with 81.3% for medical treatment with albendazole. Meanwhile, it increased by 58.6% for the deworming of registered dog since 2007. The accumulated costs amounted to USD 27.03 million after discount for patients and registered dog treatment, which is 1/4 of the total accumulated financial inputs (USD 110.67 million from the Chinese Government). Since the implementation of the national program, it has increased 57 times with respect to the annual financial inputs (costs) and 368 times with respect to all accumulated financial inputs (costs).

Conclusions
This study showed that in endemic areas, patient diagnosis and management, dog management and treatment over this period helped reduce the parasite load to control the disease. More attention should be paid to controlling wild canines during the ongoing program period and sustainable follow-up evaluations are crucial for success and continued implementation of the national program.
Listening to laser light interactions with objects of art: a novel photoacoustic approach for diagnosis and monitoring of laser cleaning interventions
Authors: Tserevelakis George J. , Pouli Paraskevi , Zacharakis Giannis 
Published: October 2020

Abstract
Photoacoustic (PA) imaging is a novel, rapidly expanding diagnostic technique, which has been predominately developed in the context of contemporary biomedical research studies. In this review, we demonstrate how PA technologies can break through the barriers of biomedicine to find innovative applications in cultural heritage (CH) diagnostics and laser cleaning monitoring. Having over three orders of magnitude higher transmission through strongly scattering media, compared to light in the visible and near infrared, PA signals offer substantially improved detection sensitivity, providing optical absorption contrast at high spatial resolution. This unique combination of features is employed for establishing novel diagnostic methodologies aiming to uncover well-hidden features and provide structural information in multi-layered CH objects such as paintings and documents. Finally, we demonstrate that the PA effect can be successfully utilized for the reliable monitoring of laser cleaning interventions on stonework, allowing for a safe and well-controlled cleaning procedure which will safeguard CH objects’ original surfaces. Simplicity of implementation, effectiveness and low-cost features provided by the developed diagnostic and monitoring systems, highlight the rich potential of emerging PA technologies in CH studies and offer exciting possibilities for future implementations.
Sliding layer estimation of shallow landslides on Aso volcanic mountains in Japan based on tephra layer-physical properties of soil
Authors: Istiyanti Mega Lia , Goto Satoshi , Kimura Takashi , Sato Go , Hayashi Shintaro , Wakai Akihiko , Higaki Daisuke 
Published: October 2020

AbstractShallow landslides occur frequently on the Aso volcanic mountains. The soil materials on the Aso volcanic mountains consist of tephra layers formed by volcanic activities. This study is aimed to specify the physical properties of soil that correlate with the sliding layer of a shallow landslide on the volcanic mountain area. Tephra layers consist of kuroboku and scoria layers and the differences between these layers were specified using the physical properties of soil methods. Results showed that the plasticity index and the fine fraction content can be used for estimating the sliding layer in the Aso volcanic area.
Surgical procedure for unexpected balloon burst complication during endoscopic balloon dilatation in a patient with common bile duct stones
Authors: Morishita Koji , Sasaki Hideaki 
Published: October 2020

Abstract
Background
Endoscopic balloon dilatation (EBD) is the established treatment for common bile duct (CBD) stones. Although pancreatitis and bleeding have been reported as major complications of EBD, balloon-related complications are rarely reported in EBD.

Case presentation
A 30-year-old woman with suspected CBD stones underwent endoscopic retrograde cholangiopancreatography (ERCP) and EBD. During EBD, the balloon of the EBD catheter suddenly burst at the biliary sphincter. We therefore performed surgical intervention: removal of the broken EBD catheter and T-tube drainage. Finally, the patient was discharged without any complications.

Conclusions
We present a case involving a burst balloon of an EBD catheter as a rare complication during EBD, as well as the surgical technique that was used to treat this complication.
Blind men and the elephant: one view of the field of migration studies
Authors: DeWind Josh 
Published: October 2020

AbstractThere are many ways to conceive and represent the field of migration studies. The CrossMigration article provides us with a broad overview to help us understand and contribute to the field’s development. This article explores a number of additional and complementary views drawn from the field-building activities of the Social Science Research Council between 1994 and 2014.(Source: Charles Maurice Stebbins & Mary H. Coolidge, Golden Treasury Readers: Primer, American Book Co., New York, 1909, p. 89. For the story of the “Blind Men and the Elephant,” see pp. 87-91: https://books.google.com/books?id=_dIAAAAAYAAJ&pg=PA89#v=onepage&q&f=false:)
The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7
Authors: Foster Robert S. , Fowkes Adrian , Cayley Alex , Thresher Andrew , Werner Anne-Laure D. , Barber Chris G. , Kocks Grace , Tennant Rachael E. , Williams Richard V. , Kane Steven , Stalford Susanne A. 
Published: October 2020

AbstractThe use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is recommended when two complementary (quantitative) structure-activity relationship (Q)SAR models are used. Using two systems may increase the sensitivity and accuracy of predictions but also increases the need to review predictions, particularly in situations where results disagree. During the 4th ICH M7/QSAR Workshop held during the Joint Meeting of the 6th Asian Congress on Environmental Mutagens (ACEM) and the 48th Annual Meeting of the Japanese Environmental Mutagen Society (JEMS) 2019, speakers demonstrated their approaches to expert review using 20 compounds provided ahead of the workshop that were expected to yield ambiguous (Q)SAR results. Dr. Chris Barber presented a selection of the reviews carried out using Derek Nexus and Sarah Nexus provided by Lhasa Limited. On review of these compounds, common situations were recognised and are discussed in this paper along with standardised arguments that may be used for such scenarios in future.
Recovery of latent fingermarks from burial environments
Authors: Yong Yam Tze , Zakaria Yusmazura , Nik Hassan Nik Fakhuruddin 
Published: October 2020

Abstract
Background
Fingermarks can be found both in indoor and outdoor crime scenes. The latter could be subjected to various types of environmental insults. In many cases, criminals try to dispose of or conceal the evidence in several ways, such as throwing in the waterways or burying in the soil to avoid detection from the law enforcement agencies. Thus, crime scene investigators often face challenges to detect and develop latent fingermarks in such environments. This study aimed to investigate the persistence and ageing of latent fingermarks in a burial environment for particular periods. To date, there is a limited study that attempted to investigate the survivability of fingermarks in a burial environment.

Methodology
The experiment was carried out in two settings: preliminary and main experiments. A preliminary experiment was conducted indoor to determine the most effective chemical for fingermark development on buried metal substrates. Five different chemicals were employed to develop the latent fingermarks, namely fingermark powder dusting, small particle reagent (SPR), Sudan black, oil red O, and crystal violet. The main experiment was carried out to simulate the realistic situation in which the metal substrates bearing latent fingermarks were buried in the soil within 2 months period. In both experiments, the substrates were buried in peat soil at a depth of 10 cm from the surface.

Results
The results demonstrated that latent fingermarks could be effectively recovered after being buried in the soil up to 8 weeks using Sudan black. The position of the substrates whether underlying in “face up” or “face down” orientations when buried had also influenced the quality of the developed fingermarks. Fingermarks buried in the “face up” position demonstrated better quality and more ridge details as compared to those buried in the “face down” position. Secondary fingermarks were also observed in this study and found to be useful for identification and must be taken into consideration when developing fingermarks on buried items in forensic cases.

Conclusion
The development of fingermarks recovered from burial environments is feasible as excellent ridge characteristics can still be identified. Hence, any evidence recovered from burial sites should be examined for fingermarks and cannot be discounted.
Biodegradation potential of indigenous litter dwelling ligninolytic fungi on agricultural wastes
Authors: Geethanjali P. A. , Gowtham H. G. , Jayashankar M. 
Published: October 2020

AbstractBackgroundThe present study was focused to study the efficiency of two indigenous litter dwelling ligninolytic fungi (such asMucor circinelloidesGL1 andFusarium verticillioidesGL5) in degrading the agricultural wastes (areca husk, coffee husk and paddy straw) through solid-state fermentation.ResultsAfter fermentation process, the lignocellulosic residues left over were evaluated for their physico-chemical studies and degradation pattern of cell wall constituents along with the activity of enzymes. In each substrate, the initial pH was found to change from near-neutral to acidic pH after fungal decomposition. Significantly increased loss of total organic matter and organic carbon content was observed in each substrate decomposed by the fungal strains selected. The total nitrogen, crude protein, total phosphorus and total potassium contents of the fungal decomposed substrates were significantly increased with the progress of time. The study indicated that the degradation patterns of lignin and holocellulose were more effective from 20 to 120 days after fungal inoculation with respect to their loss between the different harvesting intervals. During decomposition process, both the strains produced the ligninolytic enzymes [laccase, manganese peroxidase (MnP) and lignin peroxidase (LiP)] and carboxymethyl cellulase (CMCase) on each substrate with their remarkably varied activities with respect to different harvesting times.ConclusionsIn concern with the present environmental problems, the present study suggested that these potential ligninolytic fungi can be utilized successfully for the management of agricultural wastes and reuse of their residues in the forest soil conservation system to eliminate the harmful effects of the crop residue burning.
Economic emission dispatch on unit commitment-based microgrid system considering wind and load uncertainty using hybrid MGWOSCACSA
Authors: Dey Bishwajit , Bhattacharyya Biplab , Raj Saurav , Babu Rohit 
Published: October 2020

AbstractEconomic emission dispatch (EED) of a three-unit stand-alone microgrid system supported by a wind farm is percolated in this paper. The adverse effects of stochastic and uncertainty nature of wind energy in raising the generation cost of the microgrid system are studied in this article. Unit commitment (UC) of the generating units is taken into account which helps in reducing the generation cost and provides relaxation time to the generation units. Three cases are contemplated for the study. For the first two cases, the generation cost of the test system was minimized without and with the involvement of wind power, respectively. The third case considered the involvement of wind power along with the UC of the conventional generation units. A novel hybrid of recently developed superior optimization algorithms, viz. grey wolf optimizer (GWO), sine–cosine algorithm (SCA) and crow search algorithm (CSA), is implemented to perform EED, and the results are compared with basic GWO and other hybrid algorithms. Results are then analysed to compare and contrast among these cases and justify the reliable and profitable one. Statistical analysis claims the superiority of the proposed hybrid MGWOSCACSA over other hybrids and GWO.
Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films
Authors: Al-Sahaf Zahra , Raimi-Abraham Bahijja , Licciardi Mariano , de Mohac Laura Modica 
Published: October 2020

AbstractThis study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two different concentrations of PVA (5% w/v and 7.5% w/v) were used. Solvent casting was used to prepare films, where a solution consisting of drug and polymer was cast and allowed to dry. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) were used to investigate the properties of films. In vitro dissolution studies were also conducted to investigate drug release. SEM studies showed that films containing a higher concentration of PVA had larger particles in microrange. FTIR studies confirmed the presence of the drug in films and indicated that ibuprofen sodium did not react with polymers. DSC studies confirmed the crystalline form of ibuprofen sodium when incorporated within films. In vitro dissolution studies found that the dissolution percentage of ibuprofen sodium alone was increased when incorporated within the film from 59 to 74%. This study led to the development of solid microcrystalline dispersion as a buccal film with a faster dissolution rate than the drug alone overcoming problem of poor solubility.
Prioritising key motivators and challenges influencing informal carers’ decisions for participating in randomised trials: An embedded Study Within A before and after Trial (SWAT 55)
Authors: Smith Valerie , Corry Margarita , Devane Declan , Treweek Shaun , Hunter Andrew , Grylka-Baeschlin Susanne , Hannon Kathleen 
Published: October 2020

Background: Family members, or others, often assume the role of informal (unpaid) carers of people with chronic illnesses. Care-giving, however, can impact profoundly on the quality of life of carers and can cause carer worry, stress and guilt. Implementing interventions that positively affect the lives of carers is important; however, carers as a group are often difficult to reach. We embedded a study within a pilot-feasibility trial of a mindfulness based intervention to determine and prioritise the key motivators and challenges influencing informal carers’ decisions for participating in a trial. Methods: We used a multi-method approach involving interviews with participants from a ‘host trial’ and data from systematic reviews to develop a survey that was distributed to informal carers in Ireland. The survey consisted of 28 motivator and 17 challenge statements. Participants rated how important they thought each statement was when deciding to take part in a trial on a 5-point Likert Scale. Mean scores and standard deviations were calculated for each statement and arranged in descending order to provide the priority lists. Results: Thirty-six carers responded to the survey. Helping to create awareness about carers was the top ranked motivator, followed by four study design statements related to the time at which the study occurs, the study location, format of delivery and venue. The least important motivator related to how carers were invited to take part in a study. Difficulties in planning due to the caring role emerged as the most important challenge, followed by being unable to leave the care recipient on his/her own. Conclusions: Insight into decision-making for research participation will assist trial developers tailor trial processes for informal carer populations. We recommend that trialists should consider these motivators and challenges when designing future trials involving informal carers so as to enhance trial feasibility and success.
Dietary interventions with or without omega-3 supplementation for the management of rheumatoid arthritis: a systematic review protocol
Authors: Raad Tala , George Elena , Griffin Anne , Larkin Louise , Fraser Alexander , Kennedy Norelee , Tierney Audrey 
Published: October 2020

Background:Rheumatoid arthritis (RA) is an autoimmune disease characterised by swollen and painful joints. It is hypothesised that changes in lifestyle factors such as consuming a healthier diet may reduce the severity of RA symptoms. People living with RA commonly make alterations to their dietary intake with the hope of improving their symptoms. This systematic review aims to discuss the effects of dietary interventions with and without omega-3 supplementation for the management of rheumatoid arthritis.Methods:A systematic review of randomised controlled trials (RCTs) and non-randomised controlled trials (NRCTs) will be conducted. MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register) and CINAHL will be searched from inception without using date restrictions. Primary outcomes will include measures of disease activity, inflammation and quality of life among adults living with RA. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the methodological appraisal of the studies will be assessed independently by two different reviewers (TR and AG) using the Cochrane Risk-of-Bias Tool for RCTs, and Risk-of-Bias In Non-Randomised Studies Tool for NRCTs.Ethics and dissemination:Ethical approval is not required for this systematic review. Only publically available data from previously published studies will be used. The findings of this systematic review will be submitted for publication in a peer-reviewed journal and presented at relevant conferences.PROSPERO registration:CRD42020147415(11/02/2020).