bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring Firms’ Market Orientation Using Textual Analysis of 10‐K Filings
Authors: Andreou Panayiotis C. , Harris Terry , Philip Dennis 
Published: January 2020

AbstractMarket‐oriented firms are committed to understanding their customers’ evolving expectations and meeting their needs, while outwitting competitors, to achieve a sustainable competitive advantage and improve performance. This paper develops a measure for market orientation based on textual analysis of 10‐K filings. It utilizes a bag‐of‐words method to identify relevant information from the management's disclosure that underpins the corporate traits measured by the MKTOR scale, a renowned survey instrument for measuring market orientation. Unlike previous studies that rely extensively on small‐scale survey data to estimate market orientation, this novel method leverages instead on the use of big public archival data. We empirically establish strong construct validity for the measures of market orientation and its components, namely customer orientation and competitor orientation. Furthermore, our analyses demonstrate that firms’ performance is positively affected by market orientation and that this relationship is more pronounced in competitive environments. We contribute to the literature by developing an elegant measure of market orientation, which allows for conducting large‐scale longitudinal analyses of its antecedents and consequences.
Child outcomes after amnioinfusion compared with no intervention in women with second‐trimester rupture of membranes: a long‐term follow‐up study of the PROMEXIL‐III trial
Authors: de Ruigh AA , Simons NE , van 't Hooft J , van Teeffelen AS , Duijnhoven RG , van Wassenaer‐Leemhuis AG , Aarnoudse‐Moens C , van de Beek C , Oepkes D , Haak MC , Woiski M , Porath MM , Derks JB , van Kempen LEM , Roseboom TJ , Mol BW , Pajkrt E 
Published: January 2020

ObjectiveTo assess the effect of transabdominal amnioinfusion or no intervention on long‐term outcomes in children born after second‐trimester prelabour rupture of the membranes (PROM between 16+0/7–24+0/7 weeks) and oligohydramnios.PopulationFollow up of infants of women who participated in the randomised controlled trial: PPROMEXIL‐III (NTR3492).MethodsSurviving infants were invited for neurodevelopmental assessment up to 5 years of corrected age using a Bayley Scales of Infant and Toddler Development or a Wechsler Preschool and Primary Scale of Intelligence. Parents were asked to complete several questionnaires.Main outcome measuresNeurodevelopmental outcomes were measured. Mild delay was defined as −1 standard deviation (SD), severe delay as −2 SD. Healthy long‐term survival was defined as survival without neurodevelopmental delay or respiratory problems.ResultsIn the amnioinfusion group, 18/28 children (64%) died versus 21/28 (75%) in the no intervention group (relative risk 0.86; 95% confidence interval [CI] 0.60–1.22). Follow‐up data were obtained from 14/17 (82%) children (10 amnioinfusion, 4 no intervention). In both groups, 2/28 (7.1%) had a mild neurodevelopmental delay. No severe delay was seen. Healthy long‐term survival occurred in 5/28 children (17.9%) after amnioinfusion versus 2/28 (7.1%) after no intervention (odds ratio 2.50; 95% CI 0.53–11.83). When analysing data for all assessed survivors, 10/14 (71.4%) survived without mild neurodevelopmental delay and 7/14 (50%) were classified healthy long‐term survivor.ConclusionsIn this small sample of women suffering second‐trimester PROM and oligohydramnios, amnioinfusion did not improve long‐term outcomes. Overall, 71% of survivors had no neurodevelopmental delay.Tweetable abstractHealthy long‐term survival was comparable for children born after second‐trimester PROM and treatment with amnioinfusion or no intervention.
In‐group solidarity or out‐group hostility in response to terrorism in France? Evidence from a regression discontinuity design
Authors: VAN HAUWAERT STEVEN M. , HUBER ROBERT A. 
Published: January 2020

AbstractConventional wisdom holds that terrorism has a wide‐ranging impact on a polity. At the same time, a complementary, yet less extensive body of research discusses the impact of terrorism on the crux of representative democracy, namely its citizens. In contribution to that literature, and to further explore how external shocks affect public opinions, we propose a two‐dimensional analytical framework to examine the effects of the November 2015 terrorist events in Paris and Saint Denis. Drawing from extant scholarship, we argue that we can expect both in‐group solidarity and out‐group hostility to increase in direct response to these events. This study relies on a regression discontinuity design to analyse a representative survey (DREES) that was in the field at the time of the events. Findings are two‐fold. First, and perhaps surprisingly, we find no conclusive evidence of increasing out‐group hostilities as a direct consequence of the terrorist events. Second, we find a definite strengthening of in‐group solidarity indicators following the events. This not only confirms that citizens adjust their opinions in response to environmental stimuli, but also highlights the democratic resilience of citizens, particularly when faced with a collective threat. Altogether, these findings add to our understanding of why and how individual behaviour changes in light of exogenous shocks.
The Downward Spiral: Socioeconomic Causes and Consequences of Alcohol Dependence among Men in Late Young Adulthood, and Relations to Racial/Ethnic Disparities
Authors: Zemore Sarah E. , Lui Camillia , Mulia Nina 
Published: January 2020

BackgroundWhile young adults are generally at highest risk for alcohol problems, not all age out of problem drinking. Evidence suggests that Blacks and Latinos age out more slowly than Whites, particularly among men. Targeting men, we investigated whether differences in lifecourse SES might explain racial/ethnic disparities in alcohol dependence in late young adulthood, along with how experiencing alcohol dependence at that life stage relates to subsequent SES.MethodsWe used longitudinal, national data to (i) describe racial/ethnic disparities in late young adult alcohol dependence criteria (LYADC), (ii) examine whether income trajectory in early young adulthood contributes to these racial/ethnic disparities, and (iii) test whether LYADC reciprocally predicts income trajectory in early midlife. Data were from the 1979 National Longitudinal Survey of Youth (N = 3,993), which measured LYADC in 1994 (mean age = 33). Income trajectory classes were derived for early young adulthood (mean ages = 21 to 31) and, separately, early midlife (mean ages = 35 to 45). Analyses included negative binomial regressions and multinomial regressions.ResultsBoth Black and US‐born Latino men reported more LYADC than White men. Further, membership in the persistently low and slow increase (vs. stable middle) early young adult income trajectory classes was associated with more LYADC. Multivariate analyses suggested that Black–White disparities in LYADC were explained by early young adult income trajectories, whereas Latino–White disparities in the same were explained by both early young adult income trajectories and early education. In controlled models, more LYADC predicted a higher likelihood of membership in the persistently low (vs. stable middle) income trajectory class in early midlife.ConclusionsThis study found that poorer SES in early adulthood contributes to alcohol dependence, which reciprocally contributes to poorer SES in early midlife. This cycle appears particularly likely to affect Black and US‐born Latino men. Results underline the need to address socioeconomic factors in addressing racial/ethnic disparities in alcohol problems.
Brief interventions targeting long‐term benzodiazepine and Z‐drug use in primary care: a systematic review and meta‐analysis
Authors: Lynch Tom , Ryan Cristín , Hughes Carmel M. , Presseau Justin , van Allen Zachary M. , Bradley Colin P. , Cadogan Cathal A. 
Published: January 2020

AbstractAimsTo assess the effectiveness of brief interventions in primary care aimed at reducing or discontinuing long‐term benzodiazepine/Z‐drug (BZRA) use.MethodSystematic review of randomized controlled trials of brief interventions in primary care settings aimed at reducing or discontinuing long‐term BZRA use in adults taking BZRAs for ≥ 3 months. Four electronic databases were searched: PubMed, EMBASE, PsycINFO and CENTRAL. The primary outcome was BZRA use, classified as discontinuation or reduction by ≥ 25%. The Theoretical Domains Framework (TDF) was used to retrospectively code behavioural determinants targeted by the interventions. The Behaviour Change Technique (BCT) Taxonomy was used to identify the interventions’ active components. Study‐specific estimates were pooled, where appropriate, to yield summary risk ratios (RRs) and 95% confidence intervals (CIs). Pearson's correlations were used to determine the relationship between intervention effect size and the results of both the TDF and BCT coding.ResultsEight studies were included (n = 2071 patients). Compared with usual care, intervention patients were more likely to have discontinued BZRA use at 6 months (eight studies, RR = 2.73, 95% CI = 1.84–4.06) and 12 months post‐intervention (two studies, RR = 3.41, 95% CI = 2.22–5.25). TDF domains ‘knowledge’, ‘memory, attention and decision processes’, ‘environmental context and resources’ and ‘social influences’ were identified as having been included in every intervention. Commonly identified BCTs included ‘information about health consequences’, ‘credible source’ and ‘adding objects to the environment’. There was no detectable relationship between effect size and the results of either the TDF or BCT coding.ConclusionBrief interventions delivered in primary care are more effective than usual care in reducing and discontinuing long‐term benzodiazepine/Z‐drug use.
The influence of irrigation solutions in the inorganic and organic radicular dentine composition
Authors: Barón Marta , Morales Victoria , Fuentes Mª Victoria , Linares María , Escribano Nuria , Ceballos Laura 
Published: January 2020

AbstractThe aim of this study was to analyse changes in radicular dentine composition after different irrigation regimes using attenuated total reflectance Fourier‐transform infrared spectroscopy (ATR‐FTIR). Dentine slices from human single‐root teeth were immersed in: (i) 5.25% sodium hypochlorite (NaOCl) for 1, 5 and 20 min; (ii) 17% EDTA for 1 min; and (iii) 5.25% NaOCl for 20 min, and 17% EDTA and 5.25% NaOCl, both for 1 min. Carbonate/mineral, Amide I/mineral and Amide III/CH2 ratios were determined using ATR‐FTIR before and after immersion in the irrigation solutions tested. Results showed that 5.25% NaOCl significantly decreased carbonate/mineral, Amide I/mineral and Amide III/CH2 ratios (P < 0.05). Application of 17% EDTA produced no change in carbonate/mineral ratio (P = 0.120), while an increase in Amide I/mineral in apical third (P = 0.002) and Amide III/CH2 (P < 0.001) was observed. The combination of NaOCl, EDTA and NaOCl increased carbonate/mineral ratio in coronal third (P = 0.037), and Amide I/mineral (P = 0.003) and Amide III/CH2 (P = 0.001) ratios. In conclusion, irrigation solutions tested significantly affected radicular dentine composition.
Vulvar quality of life index (VQLI) – A simple tool to measure quality of life in patients with vulvar disease
Authors: Saunderson Rebecca Bronwyn , Harris Victoria , Yeh Rudy , Mallitt Kylie‐Ann , Fischer Gayle 
Published: January 2020

AbstractBackground/ObjectivesVulvar disease leads to significant disease burden and reduced quality of life (QOL). However, vulvar disease‐specific instruments to measure QOL are lacking. We developed the Vulvar Quality of Life Index (VQLI) to comprehensively and reproducibly assess symptomatic, psychosexual and physical aspects of vulvar disease.MethodsThe VQLI was inferred from a review of the literature regarding QOL of vulvar disease, and responses from a cohort of patients attending specialist clinics. Seven domains and a 15‐item questionnaire were developed. This was tested and optimised prior to validation on 248 women, using a control group as a baseline. The VQLI was further tested on 157 women, and the total VQLI score was compared to a self‐determined Likert global score on how vulvar disease had impacted their overall health.ResultsThe VQLI had excellent internal consistency (Cronbach’s alpha, 0.93), and test–retest reliability showed that 9/15 questions had a substantial weighted kappa value of 0.5 or above, with good intraclass correlation coefficient (0.88; CI 0.8–0.93). Spearman correlations were consistently positive. Further testing on 157 women demonstrated a significant relationship between the total VQLI score and the effect of vulvar disease on overall health, with high levels of the impact of vulvar disease on overall health associated with high total VQLI score (P < 0.001).ConclusionsThe VQLI is a validated, fast and reliable tool to measure the global impact of vulvar disease on QOL and can be used to monitor response to treatment or in a research setting.
Hemidiaphragmatic paralysis following ultrasound‐guided anterior vs. posterior suprascapular nerve block: a double‐blind, randomised control trial
Authors: Ferré F. , Pommier M. , Laumonerie P. , Ferrier A. , Menut R. , Bosch L. , Balech V. , Bonnevialle N. , Minville V. 
Published: January 2020

SummaryInterscalene brachial plexus block provides analgesia for shoulder surgery but is associated with hemidiaphragmatic paralysis. Before considering a combined suprascapular and axillary nerve block as an alternative to interscalene brachial plexus block, evaluation of the incidence of diaphragmatic dysfunction according to the approach to the suprascapular nerve is necessary. We randomly allocated 84 patients undergoing arthroscopic shoulder surgery to an anterior or a posterior approach to the suprascapular nerve block combined with an axillary nerve block using 10 ml ropivacaine 0.375% for each nerve. The primary outcome was the incidence of hemidiaphragmatic paralysis diagnosed by ultrasound. Secondary outcomes included: characterisation of the hemidiaphragmatic paralysis over time; numeric rating scale pain scores; oral morphine equivalent consumption; and patient satisfaction. The incidence of hemidiaphragmatic paralysis was 40% (n = 17) vs. 2% (n = 1) in the anterior and posterior groups, respectively (p < 0.001). In one third of patients with hemidiaphragmatic paralysis, it persisted beyond the eighth hour. The median (interquartile range [range]) oral morphine equivalent consumption was significantly higher in the posterior approach when compared with the anterior approach, whether in the recovery area (20 [5–31 (0–60)] mg vs. 7.5 [0–14 (0–52)] mg, respectively; p = 0.004) or during the first 24 h (82 [61–127 (12–360) mg] vs. 58 [30–86 (0–160)] mg, respectively; p = 0.01). Patient satisfaction was comparable between groups (p = 0.6). Compared with the anterior approach, diaphragmatic function is best preserved with the posterior needle approach to the suprascapular nerve block.
T‐Wave Alternans in Nonpathological Preterm Infants
Authors: Marcantoni Ilaria , Sbrollini Agnese , Agostinelli Gloria , Surace Francesca Chiara , Colaneri Massimo , Morettini Micaela , Pozzi Marco , Burattini Laura 
Published: January 2020

AbstractBackgroundSudden infant death syndrome is more frequent in preterm infants (PTI) than term infants and may be due to cardiac repolarization instability, which may manifest as T‐wave alternans (TWA) on the electrocardiogram (ECG). Therefore, the aim of the present work was to analyze TWA in nonpathological PTI and to open an issue on its physiological interpretation.MethodsClinical population consisted of ten nonpathological PTI (gestational age ranging from 29 to 34 weeks; birth weight ranging from 0.84 to 2.10 kg) from whom ECG recordings were obtained (“Preterm infant cardio‐respiratory signals database” by Physionet). TWA was identified through the heart‐rate adapting match filter method and characterized in terms of mean amplitude values (TWAA). TWA correlation with several other clinical and ECG features, among which gestational age–birth weight ratio, RR interval, heart‐rate variability, and QT interval, was also performed.ResultsTWA was variable among infants (TWAA = 26 ± 11 µV). Significant correlations were found between TWAA versus birth weight (ρ = −0.72, p = .02), TWAA versus gestational age–birth weight ratio (ρ = 0.76, p = .02) and TWAA versus heart‐rate variability (ρ = −0.71, p = .02).ConclusionsOur preliminary retrospective study suggests that nonpathological PTI show TWA of few tens of µV, the interpretation of which is still an open issue but could indicate a condition of cardiac risk possibly related to the low development status of the infant. Further investigations are needed to solve this issue.
Nutritional physiology of the Santa Ana sucker (Catostomus santaanae): A threatened freshwater fish endemic to Southern California
Authors: Nguyen‐Phuc Bao‐Quang , Demetropoulos Carl , Stewart Sam , Saffarinia Parsa , Bastian Salgado José , Hawkins Elin , Frederick Alyssa R. , German Donovan P. 
Published: January 2020

AbstractThe herbivorous fish Catostomus santaanae is a federally “threatened” freshwater fish species endemic to southern California and is the centre of legal battles over water use. Because little is known about the nutritional ecology of this species, we investigated the nutritional physiology of C. santaanae to better understand their dietary and energetic needs with the goal of generating data useful in conservation efforts. Individuals of C. santaanae were raised for six weeks on an algal diet in the laboratory. They digested approximately 45%, 55% and 80% of protein, soluble carbohydrate and lipid, respectively, from the algal diet. Their metabolic rate (~0.0024 mg O2 min−1 g−1) suggested they would need to eat more than their body mass per day of an algal diet to thrive. Digestive enzyme activities of the laboratory‐reared and wild‐caught fish showed patterns typical of a “plug‐flow reactor” gut with high intake and rapid gut transit. However, lipase activities remained elevated throughout the gut, and this result, coupled with the lipid digestibility data, and evidence of feeding selectivity on specific diatom taxa in nature, suggests that C. santaanae targets diatoms as it grazes and that diatom lipid may be crucial to their survival. Our data set provides parameters that can be used in conservation modelling efforts towards habitat restoration.
The clinical and pathological panoply of systemic mastocytosis
Authors: Radia Deepti H. , Green Anna , Oni Clare , Moonim Mufaddal 
Published: January 2020

SummaryMastocytosis is a rare disease with varied presentation, myriad symptomatology and variable prognosis. Most patients present with cutaneous disease and mediator‐related symptomatology with a small subset having systemic disease (systemic mastocytosis, SM). A subset of the latter develops synchronous or metachronous haematologic neoplasms (SM‐AHN), most commonly chronic myelomonocytic leukaemia (CMML). Advanced systemic mastocytosis (ASM) is seen in a relatively small number of patients and is usually associated with organ dysfunction, and may present with hepatosplenomegaly, lymphadenopathy and ascites with progression to leukaemic transformation (mast cell leukaemia/acute myeloid leukaemia) occurring in a few patients. This paper discusses the clinical and pathologic features of the entire spectrum of SM in adults.
Use of ixazomib, lenalidomide and dexamethasone in patients with relapsed amyloid light‐chain amyloidosis
Authors: Cohen Oliver C. , Sharpley Faye , Gillmore Julian D. , Lachmann Helen J. , Sachchithanantham Sajitha , Mahmood Shameem , Fontana Marianna , Whelan Carol J. , Martinez‐Naharro Ana , Kyriakou Charalampia , Rabin Neil , Popat Rakesh , Yong Kwee , Cheesman Simon , Shah Raakhee , Hawkins Philip N. , Wechalekar Ashutosh D. 
Published: January 2020

SummaryWith improving outcomes in amyloid light‐chain (AL) amyloidosis, there is a need to study novel agents in this setting. We report outcomes of 40 patients with relapsed AL amyloidosis treated with ixazomib + lenalidomide + dexamethasone (IRd). Haematological responses were assessed on an intention‐to‐treat basis at three months: complete response (CR) – 8 (20·5%), very good partial response (VGPR) – 8 (20·5%), partial response (PR) – 7 (17·9%) and no response (NR) – 16 (41·0%). One patient had missing data. Six patients subsequently improved response. Best responses were: CR – 10 (25·6%), VGPR – 8 (20·5%), PR – 7 (17·9%), NR – 14 (35·9%). Cardiac and renal organ responses occurred in 5·6% and 13·3% respectively. Median progession‐free survival (PFS) was 17·0 months (95% CI 7·3–20·7 months), improving to 28·8 months (95% CI 20·6–37·0 months) in those achieving CR/VGPR. Median overall survival was 29·1 months (95% CI 24–33 months). Serious adverse events were seen in 14 (35·0%) patients inclusive of 15 admissions due to: infection (6/15, 40·0%), fluid overload (5/15, 33·3%), cardiac arrhythmia (2/15, 13·3%), renal dysfunction (1/15, 6·6%) and anaemia (1/15, 6·6%). In summary, IRd is an oral treatment option with a manageable toxicity profile leading to deep responses in 47% of patients with relapsed AL amyloidosis.
Urothelial cancer harbours EGFR and HER2 amplifications and exon 20 insertions
Authors: Madison Russell W. , Gupta Sumati V. , Elamin Yasir Y. , Lin Douglas I. , Pal Sumanta K. , Necchi Andrea , Miller Vincent A. , Ross Jeffrey S. , Chung Jon H. , Alexander Brian M. , Schrock Alexa B. , Heymach John V. , Reddy Prasanth , Ali Siraj M. 
Published: January 2020

ObjectiveTo review the genomic landscape of advanced urothelial carcinoma (UC) to assess the frequencies of EGFR and ERBB2 (HER2) alterations.Materials and MethodsTumour specimens from 3753 patients with advanced UC were assayed with hybrid capture‐based comprehensive genomic profiling of 180–395 genes. Tumour mutational burden (TMB) was assessed on 0.8 or 1.1 Mb of DNA, and is reported as mutations per megabase.ResultsIn 3753 cases of UC, EGFR alterations were detected in 4.1% (154) and were most commonly amplifications (64%; 99/154), while exon 20 insertions (EGFRexon20ins) were the second most common alteration (18%; 27/154). Alterations in ERBB2 were observed in 15% (552/3753) of cases and, similarly, ERBB2 amplification was the most commonly observed alteration (278/552; 50%); ERBB2exon20ins occurred in 3.6% (20/552) of cases. EGFRexon20ins and ERBB2exon20ins occurred in younger patients (median age 62 vs 69 years, P = 2.6E‐2 and 60 vs 68 years, P = 7.8E‐4), and these cases had significantly lower TMB (median 3.6 vs 7.2, P = 2.7E‐4 and 2.5 vs 10, P = 1.2E‐7) and less frequent TP53 alterations (3.7% vs 83%, P = 4.3E‐14 and 20% vs 68%, P = 9.8E‐4) compared to cases with other EGFR or ERBB2 alterations.ConclusionEGFR and ERBB2 alterations occur in 4% and 15% of UC, respectively. EGFRexon20ins and ERBB2exon20ins were present in 0.7% and 0.5% of UC overall and collectively define a small, but distinct, subset of UC with infrequent co‐occurrence of other drivers and low TMB. Given recent promising clinical studies of inhibitors with activity against exon 20 insertions in non‐small cell lung cancer, consideration should be given to developing a trial inclusive of patients with UC harbouring these alterations.