bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients
Authors: Sydorchuk Larysa , Dzhuryak Valentina , Sydorchuk Andrii , Levytska Svitlana , Petrynych Volodymyr , Knut Ruslan , Kshanovska Anna , Iftoda Oksana , Tkachuk Olexii , Kyfiak Petro , Popovich Andrii , Khomko Oleh , Sydorchuk Ruslan 
Published: August 2020

Abstract

Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes.

Methods. One-hundred hypertensive patients with target-organ damaging (2nd stage), moderate, high or very high cardiovascular risk were involved in the case-control study. Mean age was 59.87±8.02 years. Diabetes Mellitus type 2 (DM2) was in 28 persons. Chronic kidney disease (CKD) was diagnosed in 29 persons according to the National Kidney Foundation recommendations (2012) after glomerular filtration rate (GFR) decline <60 ml/min/1.73m2 for ≥3 months (measured by CKD-EPI equations). Aldosterone, cystatin-C, and creatinine levels were measured in serum. Control group included 48 practically healthy persons of relevant age. Gene’s nucleotide polymorphism CYP11B2 (-344C/T) was examined by polymerase chain reaction.

Results. CKD evolution in hypertensive patients followed by higher systolic and diastolic blood pressure (SBP, DBP) values increased creatinine, cystatin-C, and aldosterone serum concentrations by 28.76%, 28.41% and 29.43% (р<0.05), respectively. Polymorphic site of CYP11B2 (rs1799998) gene is associated with SBP and DBP increase (p<0.05), reduced GFR preferably calculated by CKDEPI-cystatin C (F=10.79–14.45; p<0.001) and elevated aldosterone content (F=55.84; p<0.001), creatinine and cystatin-С as well (F=4.16–5.08; p<0.05) mainly in the ТТ-genotype female carriers (p<0.001). Hypertensive women with DM2 demonstrated stronger relations of CYP11B2 gene polymorphic site with the increased aldosterone content (F=47.52; p<0.001), than women without DM2 (p<0.001) and male patients (p=0.014).

Conclusions. Genetic variations involving CYP11B2 might influence the kidney function, hypertension course, and severity via aldosterone secretion upregulation.
Impact of the Regularization of Regression Models on the Results of the Mass Valuation of Real Estate
Authors: Gnat Sebastian 
Published: August 2020

Abstract

Research background: Mass appraisal is a process in which multiple properties are appraised simultaneously, with a uniform approach. One of the tools that can be used in this area are multiple regression models. In the valuation of real estate features are often described on an ordinal or nominal scale. Replacing them with dummy variables with an insufficient number of observations leads to multicollinearity. On the other hand, there is a risk of overfitting the model. One of the ways to eliminate or weaken these phenomena is to introduce regularization based on a model’s penalization for the high values of its weights.

Purpose: The aim of the study is to verify the hypothesis whether regularized regression reduces the errors of property valuation and which of the analyzed methods is the most effective in this context.

Research methodology: The article will present a study in which two ways of regularization will be applied – ridge and lasso regression, in the context of their impact on the errors of property valuation. The analyzed data set includes over 300 land properties valued by property appraisers. The key aspects of the study are the selection of optimal values of the regularization parameter and its influence on model’s errors with a different number of observations in the training sets.

Results: The study showed that regularization improves valuation results and, more specifically, allows for lower average absolute percentage errors. The improvement of model effectiveness was more pronounced in the case of ridge regression. An important result is also that regularization has provided a higher accuracy of valuation compared to multiple regression models for smaller training sets.

Novelty: The article confirms the effectiveness of regularization as a way to eliminate the problem of multicollinearity or overfitting of the model. The results showed that ridge regression can be an effective way of modelling the value of real estate. Especially in the case of a small amount of market data, which is an important conclusion in the context of the real estate market.
Measures Implemented by Local Authorities, Particularly in the Sphere of Spatial Policy, and Its Impact on Setting Up and Developing Companies – Opinions Comparison
Authors: Rogalska Izabela , Marks-Bielska Renata 
Published: August 2020

Abstract

Research background: The development of business on a local level depends on a variety of factors, which as is often the case are shaped by the local authorities. An example of activities carried out by local governments in order to help develop businesses is the management of the spatial resources in a given municipality in such a way as to facilitate starting and developing companies.

Purpose: The principal objective of this study has been to identify how local authorities and businessmen perceive the role of conditions associated with the municipality’s spatial policy in terms of starting and conducting a business.

Research methodology: The research results rely on primary data acquired by conducting a survey based on a questionnaire designed by the authors.

Results: The results permitted to demonstrate differences and similarities among the opinions of our respondents concerning factors linked to the spatial policy of a municipality that have an impact on decisions to set up and develop companies. Among the location factors, the most important ones, according to both local governments and businessmen, were the state of the local infrastructure, such as IT, transportation, communication, waterworks and sewers, power supply.

Novelty: The confrontation of the replies provided by local authorities and by entrepreneurs concerns spatial policy, and the territorial scope of the research covering the whole of Poland, the different types of enterprises from various branches are the innovative element of the study.
Instruments to Support Lifelong Learning – the Context of an Employee’s Career Development
Authors: Sobocka-Szczapa Halina H. 
Published: August 2020

Abstract

Research background: The need for lifelong learning should be considered for all categories of labor resources. This study takes into account the context of this process in relation to employees for whom the most important thing is to maintain employment, promotion in the workplace or professional promotion. Lifelong learning, enabling continuous updating of qualifications, ensures a better competitive position on the labor market.

Research methodology: The basis of the analyzes carried out in this research are studies conducted in Polish organizations by experts from the Institute of Labor and Social Affairs, including the author. The research was quantitative (interview questionnaire) and qualitative (group interviews).

Results: The research work hypothesis was: Most organizations in Poland do not apply statute defined methods of supporting employee careers. This hypothesis has been verified positively. Polish enterprises have a very limited scope, and in most cases do not use tools supporting employee education at all.

Novelty: An innovative approach in the development is to indicate the relationship between the possibility of supporting the process of employee education and the course of their professional career.
A Comparison of Variables Selection Methods and their Sequential Application: A Case Study of the Bankruptcy of Polish Companies
Authors: Zanka Mikhail 
Published: August 2020

Abstract

Research background: Even though in recent decades, a lot of new techniques were developed, there is still a lack of studies aimed at comparing the performance of variable selection methods. Bankruptcy prediction is an excellent example of the conservative research field with the tendency to use classical approaches. Although the results of studies in this field are directly applied in banks and other financial institutions, variables selected for these models can be biased by the author’s preference for one technique.

Purpose: This work aims to compare different variable selection approaches and introduce a new methodology of sequential variable selection that can be applied when the low-dimensional model is preferred.

Research methodology: This study has been conducted on Polish companies’ insolvency data from the period of 2007–2013. The risk has been modeled with logistic regression; hence variables have been selected with approaches suitable for linear models.

Results: The one-step methods did not lead to sufficient dimensionality reduction, while the sequential approach provided compact models keeping the high-performance level. Also, this method allowed us to identify the main financial determinants of insolvency for studied companies, which are the volume of total assets and the ratio of profit to total assets.

Novelty: This paper compares different variable selection methods and demonstrates the effectiveness of their sequential application for dimensionality reduction.
Plant communities of moist rock crevices with endemic Primula carniolica in the (sub)montane belt of western Slovenia
Authors: Dakskobler Igor , Martinčič Andrej 
Published: August 2020

Abstract
Based on our analysis of a large number of relevés of communities of moist rock crevices in western Slovenia (southern Julian Alps, northern part of the Trnovski Gozd Plateau) we described several new syntaxa with the endemic Primula carniolica. The most unique in terms of ecology is a hygrophytic chasmophytic community classified into the association Astrantio carniolicae-Primuletum carniolicae, which is, together with similar hygrophytic associations Astrantio carniolicae-Pinguiculetum alpinae and Campanulo cespitosae-Saxifragetum aizoidis, associations Phyteumato columnae-Primuletum carniolicae, Primulo carniolicae-Potentilletum clusianae and the subassociation Primuletum carniolicae violetosum biflorae, temporarily classified into the alliance Cystopteridion and order Potentilletalia caulescentis. Only the new association Paederoto luteae-Potentilletum caulescentis is classified into the alliance Physoplexido comosae-Saxifragion petraeae. The elevational range of chasmophytic communities with Primula carniolica is 200 to 1460 m a.s.l. Species that most commonly accompany Primula carniolica in rock crevices include Paederota lutea, Phyteuma scheuchzeri subsp. columnae, Sesleria caerulea, Aster bellidiastrum and moss Orthothecium rufescens.
Who helps the unemployed? Workers’ receipt of public and private transfers
Authors: Edwards Kathryn Anne 
Published: August 2020

Abstract
I use longitudinal data from the Panel Study of Income Dynamics (PSID) to measure the extent to which an unemployment spell increases the likelihood that a worker receives a cash transfer from family. I examine the prevalence of cash transfers from family, the demographic distribution of unemployed receivers, and the variation between family supported and not family supported spells. I further investigate how this informal, private assistance relates to public transfers from Unemployment Insurance using state-by-year variation in the UI program. I find that unemployment increases the probability a worker receives financial assistance from their family, inclusive of all demographic subgroups, that family cash transfer receipt is growing over time, and is weakly related to UI availability.
Triangular Fuzzy-Rough Set Based Fuzzification of Fuzzy Rule-Based Systems
Authors: Starczewski Janusz T. , Goetzen Piotr , Napoli Christian 
Published: August 2020

Abstract
In real-world approximation problems, precise input data are economically expensive. Therefore, fuzzy methods devoted to uncertain data are in the focus of current research. Consequently, a method based on fuzzy-rough sets for fuzzification of inputs in a rule-based fuzzy system is discussed in this paper. A triangular membership function is applied to describe the nature of imprecision in data. Firstly, triangular fuzzy partitions are introduced to approximate common antecedent fuzzy rule sets. As a consequence of the proposed method, we obtain a structure of a general (non-interval) type-2 fuzzy logic system in which secondary membership functions are cropped triangular. Then, the possibility of applying so-called regular triangular norms is discussed. Finally, an experimental system constructed on precise data, which is then transformed and verified for uncertain data, is provided to demonstrate its basic properties.
In silico and in vitro conductivity models of the left heart ventricle
Authors: Korn Leonie , Lyra Simon , Rüschen Daniel , Telyshev Dmitry , Leonhardt Steffen , Walter Marian 
Published: August 2020

Abstract
Ventricular Assist Devices (VADs) are used to treat patients with cardiogenic shock. As the heart is unable to supply the organs with sufficient oxygenated blood and nutrients, a VAD maintains the circulation to keep the patient alive. The observation of the patient's hemodynamics is crucial for an individual treatment; therefore, sensors to measure quantifiable hemodynmaic parameters are desirable.
In addition to pressure measurement, the volume of the left ventricle and the progress of muscle recovery seem to be promising parameters. Ongoing research aims to estimate ventricular volume and changes in electrical properties of cardiac muscle tissue by applying bioimpedance measurement. In the case where ventricular insufficiency is treated by a catheter-based VAD, this very catheter could be used to conduct bioimpedance measurement inside the assisted heart. However, the simultaneous measurement of bioimpedance and VAD support has not yet been realized, although this would allow the determination of various loading conditions of the ventricle. For this purpose, it is necessary to develop models to validate and quantify bioimpedance measurement during VAD support.
In this study, we present an in silico and an in vitro conductivity model of a left ventricle to study the application of bioimpedance measurement in the context of VAD therapy. The in vitro model is developed from casting two anatomical silicone phantoms: One phantom of pure silicone, and one phantom enriched with carbon, to obtain a conductive behavior close to the properties of heart muscle tissue. Additionally, a measurement device to record the impedance inside the ventricle is presented. Equivalent to the in vitro model, the in silico model was designed. This finite element model offers changes in material properties for myocardium and the blood cavity.
The measurements in the in vitro models show a strong correlation with the results of the simulation of the in silico model. The measurements and the simulation demonstrate a decrease in impedance, when conductive muscle properties are applied and higher impedances correspond to smaller ventricle cross sections.
The in silico and in vitro models are used to further investigate the application of bioimpedance measurement inside the left heart ventricle during VAD support. We are confident that the models presented will allow for future evaluation of hemodynamic monitoring during VAD therapy at an early stage of research and development.
Experimental investigation of the effect of vegetation on dam break flood waves
Authors: Oguzhan Semire , Aksoy Aysegul Ozgenc 
Published: August 2020

Abstract
Dams have an important role in the industrial development of countries. Irrespective of the reason for dam break, the flood can cause devastating disasters with loss of life and property especially in densely populated areas. In this study, the effects of the vegetation on the flood wave propagation in case of dam break were investigated experimentally by using the distorted physical model of Ürkmez Dam. The horizontal and vertical scales of the distorted physical model are 1/150 and 1/30, respectively. The dam break scenarios were achieved by means of a gate of rectangular and triangular shape. The results obtained from experiments performed with vegetation were compared and interpreted with those obtained from experiments at which the vegetation configuration was absent. The analysis of the experimental data showed that the presence of vegetation causes a significant decrease in water depths as the flood wave propagates to the downstream and greatly reduces its impact on the settlements. It is also revealed that dam break shape plays an important role in temporal variation of flood wave.
Education for Sustainable Development as Diffusion of Innovation of Secondary School Students
Authors: Prabawani Bulan , Hadi Sudharto P. , Zen Irina Safitri , Afrizal Teuku , Purbawati Dinalestari 
Published: August 2020

Abstract
Education for sustainable development (ESD) is essential to study in order to understand environmental changes from the perspective of student character building. This concept is the main foundation that refers to individual personality as a medium to build excellent capacity from an early age. At adolescent age, children experience a period with high emotional growth that encourages changes in attitudes and behavior patterns towards the surrounding environment. This exploratory study aimed at describing the relationship between environmental knowledge and studentsí attitudes and behaviors, along with challenging factors as the moderating variable, involving 320 participants from two junior high schools in two cities in Central Java, Indonesia. The data were analyzed using partial least square Smartpls v3.0. This study found that junior high school students had low environmental and social knowledge, but there was a good attitude and behavior tendency concerning the environment. The studentsí knowledge significantly influenced environmentally-friendly attitudes and behaviors, especially the social environment that the obstacles also became a significant moderating variable. Thus, schools and related parties should develop programs to increase the studentsí study orientation towards the environment and to have a collective awareness of the environment, specifically the ability to analyze and synthesize the surroundings.
The corrosion-resistant Ni-based coatings and their tribological properties
Authors: Zdravecká E. , Tkáčová J. 
Published: August 2020

Abstract
Ni-based coatings can be successfully applied under abrasive and adhesive conditions as a substitute for environmentally harmful chrome coatings. The research has been carried out for thermally flame sprayed Ni-based coatings with remelting (so-called the two-step process) with the different chemical composition of starting powders. The structure of coatings was evaluated by optical and scanning electron microscopy. Both the three-body abrasive wear test, according to ASTM G65-4 (Dry-Sand Rubber Wheel Test) and dry sliding wear test by the Falex tester, were performed. The results show the influence of the effective chemical composition of the metal powders on improving the properties of the coating. The higher hardness of the coatings leads to a lower tendency for the creation of adhesive bonds, and as a result, leads to a lower tendency to scuffing. A similar trend shows the influence of higher coating hardness on the increasing of abrasive wear resistance.
Corrosion inhibition of mild steel using novel pyridine derivative in 1 M hydrochloric acid
Authors: Al-Amiery A.A. , Shaker L.M. 
Published: August 2020

Abstract
A novel pyridine derivative was synthesized, and its corrosion inhibition effects on mild steel in a 1M hydrochloric acid environment were investigated by gravimetric techniques, The results demonstrated that the inhibitive performance increased with the increasing of inhibitor concentration. At 303, the inhibition efficiency of pyridine derivative 4-hydroxy-3-(pyridin-2-ylaminomethyl)toluene accomplished 96.2% at the inhibitor concentration of 0.005 M. The mechanism of inhibition implicated the forming of a protective layer from inhibitor molecules on the surface of mild steel by a Langmuir adsorption isotherm. The presence of nitrogen and oxygen atoms in the structure of 4-hydroxy-3-(pyridin-2-ylaminomethyl)toluene confirmed by CHN-analysis revealed the adsorption of inhibitor molecules on the surface of mild steel surface.
Spectral–time analysis of cycle fluctuations in lake water levels in Belarus and Poland
Authors: Volchak Alexander A. , Kirvel Ivan , Choiński Adam , Parfomuk Sergey I. , Kirvel Pavel , Sidak S. 
Published: August 2020

Abstract
On the basis of the mean volume of annual water levels of 25 lakes (9 Belarusian and 16 Polish) over a period of 55 years (1956-2010) spectral time analysis of water fluctuations has been executed. The choice of the lakes was based on two factors, i.e. the continuous period of observation and insignificant anthropogenic influence. The complex analysis of water level fluctuation cycles has shown that for Belarus the cycles observed most often were 3, 5 and 10-year cycles. Polish lakes also have three cycles, but in the majority of them they amount to 5 and 10-years. It can be assumed that this is impacted by the continental climate growing to the east. Most probably it is one of the key factors defining the diversity of water fluctuations in all the analyzed lakes.
Application of the Philosophy of Management and Production Engineering in Eastern Asia in Improving the Processes of Urban Transport Operation
Authors: Wieczorek Andrzej , Madej Robert 
Published: August 2020

AbstractThe subject matter presented in the article touches the problem of incufficient efficiency of processes and systems in organisation. Achievement of adequate efficiency value is a guarantor of competitive advantage of enterprise. Therefore, it is necessary to constantly work on methods and techniques to improve efficiency, tailored to the needs of various organizations, which also includes service enterprises. Service enterprises include public transport companies. The purpose of the latter is to guarantee that the passenger will be transported from stop A to stop B within a certain time. Failure to achieve this goal incurs certain social costs. Therefore, the article focuses on measures and ways to improve efficiency, developed in Eastern Asian enterprises that have been successful as a result of their use. The first part of the article reviews the literature, including the methods used in this part of the world. The second part, however, concerns the possibility of using the BOST method in improving the efficiency of public transport enterprise processes in Poland.
Do the Owners and Managers of Polish MSME’s Recognize and Understand Properly the Challenges of “Industry 4.0”?
Authors: Kaźmierczak Jan 
Published: August 2020

Abstract
In the article, the author presents in an expanded approach the results of previously conducted research, described in his previous publications and aimed at understanding the needs and capabilities of Polish micro, small and medium sized enterprises (MSMEs) in recognizing challenges and implementing practical solutions from the area fitted to of the Industry 4.0 paradigm. In addition to the detailed and based on selected examples discussion of the results of the first round of surveys conducted among the owners and management staff of this category of enterprises operating in the area of the Upper Silesian – Zagłębie Metropolis in the Upper Silesian Voivodship, the results obtained in the second round of research were also shown and compared with first-round results. The results obtained are the basis for the plan of further, extended research. The author presents the elements of such research plan in the last part of this article.