bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RESPECT Study for consensus on global bereavement care after stillbirth
Authors: Shakespeare Clare , Merriel Abi , Bakhbakhi Danya , Blencowe Hannah , Boyle Frances M. , Flenady Vicki , Gold Katherine , Horey Dell , Lynch Mary , Mills Tracey A. , Murphy Margaret M. , Storey Claire , Toolan Miriam , Siassakos Dimitrios ,   RESPECT (Research of Evidence based Stillbirth care Principles to Establish global Consensus on respectful Treatment) working group
Published: February 2020

AbstractObjectiveTo develop global consensus on a set of evidence‐based core principles for bereavement care after stillbirth.MethodsA modified policy‐Delphi methodology was used to consult international stakeholders and healthcare workers with experience in stillbirth between September 2017 and October 2018. Five sequential rounds involved two expert stakeholder meetings and three internet‐based surveys, including a global internet‐based survey targeted at healthcare workers in a wide range of settings.ResultsInitially, 23 expert stakeholders considered 43 evidence‐based themes derived from systematic reviews, identifying 10 core principles. The global survey received 236 responses from participants in 26 countries, after which nine principles met a priori criteria for inclusion. The final stakeholder meeting and internet‐based survey of all participants confirmed consensus on eight core principles. Highest quality bereavement care should be enabled through training of healthcare staff to reduce stigma and establish respectful care, including acknowledgement and support for grief responses, and provision for physical and psychologic needs. Women and families should be supported to make informed choices, including those concerning their future reproductive health.ConclusionConsensus was established for eight principles for stillbirth bereavement care. Further work should explore implementation and involve the voices of women and families globally.
Sexual and reproductive health and rights of refugee and migrant women: gynecologists’ and obstetricians’ responsibilities
Authors: Endler Margit , Al Haidari Taghreed , Chowdhury Sameena , Christilaw Jan , El Kak Faysal , Galimberti Diana , Gutierrez Miguel , Ramirez‐Negrin Atziri , Senanayake Hemantha , Sohail Rubina , Temmerman Marleen , Danielsson Kristina Gemzell ,   the FIGO Committee for Human Rights, Refugees and Violence Against Women
Published: February 2020

AbstractEnsuring universal access to sexual and reproductive healthcare services is Target 3.7 of the United Nations Sustainable Development Goals (SDG). Refugee and migrant women and children are at particular risk of being forgotten in the global momentum to achieve this target. In this article we discuss the violations of sexual and reproductive health and rights (SRHR) of particular relevance to the refugee and migrant reality. We give context‐specific examples of denial of health services to vulnerable groups; lack of dignity as a barrier to care; the vulnerability of adolescents; child marriage; weaponized rape; gender‐based violence; and sexual trafficking. We discuss rights frameworks and models that are being used in response to these situations, as well as what remains to be done. Specifically, we call for obstetricians and gynecologists to act as individual providers and through their FIGO member societies to protect women's health and rights in these exposed settings.
Rare‐earth‐incorporated low‐dimensional chalcogenides: Dry‐method syntheses and applications
Authors: Zhang Zheshan , Zhao Hongyang , Zhang Chao , Luo Feng , Du Yaping 
Published: February 2020

AbstractChalcogenide thin films incorporating rare‐earth (RE) elements with applications in optics, electronics, and magnetics have received considerable attention. Aiming at growing pure chalcogenides, dry‐method syntheses have been developed. In this review, we summarize the progress thus far on low‐dimensional RE‐based chalcogenides (RECs), covering fabrication methods, structures, and applications. This review also provides the summary and perspectives of the challenges of fabrication and opportunities on the application of RECs in the future.image
Big data tools for Islamic financial analysis
Authors: Mnif Emna , Jarboui Anis , Hassan M. Kabir , Mouakhar Khaireddine 
Published: February 2020

SummaryBehavioural science states that emotions, principles and the manner of thinking can affect the behaviour of individuals and even investors in their decision making on financial markets. In this paper, we have tried to measure the investor sentiment by three means of big data. The first is based on a search query of a list of words related to Islamic context. The second is inferred from the engagement degree on social media. The last measure of sentiment is built, based on the Twitter API classified into positive and negative directions by a machine learning algorithm based on the naive Bayes method. Then, we investigate whether these sensations and emotions have an impact on the market sentiment and the price fluctuations by means of a vector autoregression model and Granger causality analysis. In the final step, we apply the agent‐based simulation by means of the sequential Monte Carlo method with the control of our Twitter measure on Islamic index returns. We show, then, that the three social media sentiment measures present a remarkable impact on the contemporaneous and lagged returns of the different Islamic assets studied. We also give an estimation of the parameters of the latent variables relative to the agent model studied.
Front Cover: Label‐free spectroscopic tissue characterization using fluorescence excitation‐scanning spectral imaging (J. Biophotonics 2/2020)
Authors: Favreau Peter F. , Deal Joshua A. , Harris Bradley , Weber David S. , Rich Thomas C. , Leavesley Silas J. 
Published: February 2020

A false‐colored and merged image of fresh, ex vivo rat kidney acquired using an excitation‐scanning hyperspectral imaging system. The spectral image was acquired using excitation wavelengths from 360 to 550 nm. Colors represent principal components extracted from a spectral image cube featuring no added labels or markers.Further details can be found in the article by Peter F. Favreau, Joshua A. Deal, Bradley Harris, et al. (e201900183).
image
miR‐497‐5p mediates starvation‐induced death in colon cancer cells by targeting acyl‐CoA synthetase‐5 and modulation of lipid metabolism
Authors: Gharib Ehsan , Nasri Nasrabadi Parinaz , Reza Zali Mohammad 
Published: February 2020

AbstractModulation of fatty acids metabolism is an appropriate strategy for starvation‐induced death in tumor cancers. Colon cancer cells express a high level of acyl‐CoA synthetase‐5 (ACSL5), and as yet no therapeutic approach has been achieved. Herein, ACSL5‐related microRNAs (miRNAs) were identified via TargetScan, and their impacts on ACSL5 and lipid content along with metabolic activity, cell cycle, migration, and invasion of colorectal cancer (CRC) cells were examined, and subsequently compared with transcriptome for better visualization of intracellular‐signaling networks. In vivo analysis was performed using BALB/c mice xenograft model of CRC injected with target miRNA. Clinical significances were also evaluated in 80 CRC tumors and matched adjacent normal tissues. There was a reverse correlation between ACSL5 and miR‐497‐5p, which miR‐497‐5p overexpression modulated CRC cell proliferation and development. A similar observation was received from the in vivo examination in which intratumoral injection of miR‐497‐5p reversed the tumor growth in the CRC xenograft model. Downregulation of miR‐497‐5p correlated with tumor differentiation, tumor, node, and metastasis staging, lymph node metastasis, and poor survival in patients with CRC. These results suggested that miR‐497‐5p upregulation could be considered as a therapeutic strategy for modulation of lipid metabolism in colon cancer.
Impact of systematic segmentectomy for small hepatocellular carcinoma
Authors: Kaibori Masaki , Yoshii Kengo , Hasegawa Kiyoshi , Ariizumi Shunichi , Kobayashi Tsuyoshi , Kamiyama Toshiya , Kudo Atsushi , Yamaue Hiroki , Kokudo Norihiro , Yamamoto Masakazu 
Published: February 2020

AbstractBackgroundWe compared survival after resection by systematic segmentectomy (SS) versus non‐anatomic resection (NAR) in patients with small, solitary hepatocellular carcinomas (HCCs).MethodsTo control for variables, we used 1‐to‐1 propensity score matching to compare outcomes after surgery among 615 patients in Japan between 2003 and 2007 with primary solitary HCCs ≤3 cm in diameter who received SS (n = 114) or NAR (n = 114) of one Couinaud segment with complete removal of the portal territory containing the tumor.ResultsWe successfully matched SS and NAR patients with primary HCC tumors ≤3.0 cm and similar liver function and tumor characteristics. The SS group had significantly longer recurrence‐free survival (RFS; hazard ratio [HR] 1.56, 95% confidence interval [CI] 1.10‐2.21, P = .013) and overall survival (OS; HR 1.67, 95% CI 1.07‐2.60, P = .025) than the NAR group. Among patients who lost >400 mL of blood during surgery, had chronic hepatitis, or had cirrhosis, the RFS and OS were better in the SS group than in the NAR group. In Cox proportional hazard analysis, SS offered a better prognosis than NAR.ConclusionsSystematic segmentectomy decreases the risk of recurrence and improves OS in patients with primary, solitary HCC tumors of ≤3 cm in diameter.
So You Want to Image Myelin Using MRI: An Overview and Practical Guide for Myelin Water Imaging
Authors: Lee Jongho , Hyun Jae‐Won , Lee Jieun , Choi Eun‐Jung , Shin Hyeong‐Geol , Min Kyeongseon , Nam Yoonho , Kim Ho Jin , Oh Se‐Hong 
Published: February 2020

Myelin water imaging (MWI) is an MRI imaging biomarker for myelin. This method can generate an in vivo whole‐brain myelin water fraction map in approximately 10 minutes. It has been applied in various applications including neurodegenerative disease, neurodevelopmental, and neuroplasticity studies. In this review we start with a brief introduction of myelin biology and discuss the contributions of myelin in conventional MRI contrasts. Then the MRI properties of myelin water and four different MWI methods, which are categorized as T2‐, T2*‐, T1‐, and steady‐state‐based MWI, are summarized. After that, we cover more practical issues such as availability, interpretation, and validation of these methods. To illustrate the utility of MWI as a clinical research tool, MWI studies for two diseases, multiple sclerosis and neuromyelitis optica, are introduced. Additional topics about imaging myelin in gray matter and non‐MWI methods for myelin imaging are also included. Although technical and physiological limitations exist, MWI is a potent surrogate biomarker of myelin that carries valuable and useful information of myelin.Evidence Level: 5Technical Efficacy: 1J. MAGN. RESON. IMAGING 2021;53:360‐373.
Comparison of 3D printed nose bolus to traditional wax bolus for cost‐effectiveness, volumetric accuracy and dosimetric effect
Authors: Albantow Christine , Hargrave Catriona , Brown Amy , Halsall Christopher 
Published: February 2020

AbstractIntroductionThree‐dimensional printing technology has the potential to streamline custom bolus production in radiotherapy. This study evaluates the volumetric, dosimetric and cost differences between traditional wax and 3D printed versions of nose bolus.MethodNose plaster impressions from 24 volunteers were CT scanned and planned. Planned virtual bolus was manufactured in wax and created in 3D print (100% and 18% shell infill density) for comparison. To compare volume variations and dosimetry, each constructed bolus was CT scanned and a plan replicating the reference plan fields generated. Bolus manufacture time and material costs were analysed.ResultsMean volume differences between the virtual bolus (VB) and wax, and the VB and 18% and 100% 3D shells were −3.05 ± 11.06 cm3, −1.03 ± 8.09 cm3 and 1.31 ± 2.63 cm3, respectively. While there was no significant difference for the point and mean doses between the 100% 3D shell filled with water and the VB plans (P> 0.05), the intraclass coefficients for these dose metrics for the 100% 3D shell filled with wax compared to VB doses (0.69–0.96) were higher than those for the 18% and 100% 3D shell filled with water and the wax (0.48–0.88). Average costs for staff time and materials were higher for the wax ($138.54 and $20.49, respectively) compared with the 3D shell prints ($10.58 and $13.87, respectively).ConclusionThree‐dimensional printed bolus replicated the VB geometry with less cost for manufacture than wax bolus. When shells are printed with 100% infill density, 3D bolus dosimetrically replicates the reference plan.
Passion at work: A meta‐analysis of individual work outcomes
Authors: Pollack Jeffrey M. , Ho Violet T. , O'Boyle Ernest H. , Kirkman Bradley L. 
Published: February 2020

SummaryAcademic research on passion is much more complex than the extant literature or popular press portray. Although research on work‐related passion has progressed rapidly over the last decade, much remains unknown. We are now just beginning to recognize the different theoretical underpinnings and empirical operationalizations that work passion research has adopted, and the confusion this has generated hampers our understanding of the construct and its relationship to workplace outcomes. Accordingly, we use a meta‐analytic examination to study the work‐related outcomes of three dominant literature streams of work passion: general passion, dualistic passion (i.e., harmonious passion and obsessive passion), and role‐based passion (i.e., passion for developing, passion for founding, and passion for inventing). We employ meta‐analytic techniques using random effects modeling summarizing 106 distinct samples across 87 manuscripts totaling 384 effect sizes (total unique N = 38,481; 43.54% women, average age is 38.04). Importantly, we highlight how each of the three streams of passion relates to various outcomes differently, illuminate several important heretofore undetected nuances in passion research, and provide a roadmap for future inquiry on passion at work.
Review of Outcomes Used in Nutrition Trials in Pediatric Critical Care
Authors: Gadhvi Kunal R. , Valla Frédéric V. , Tume Lyvonne N. 
Published: February 2020

AbstractBackgroundGenerating robust evidence within pediatric intensive care (PIC) can be challenging because of low patient numbers and patient heterogeneity. Systematic reviews may overcome small study biases but are limited by lack of standardization in outcome measures and their definition. Trials of nutrition interventions in PIC are increasing; thus, we wanted to examine the outcome measures being used in these trials.ObjectiveOur objective was to systematically describe outcome measures used when a nutrition intervention has been evaluated in a PIC randomized controlled trial.MethodsA systematic literature review of all studies involving a PIC trial of a nutrition intervention was undertaken from January 1, 1996, until February 20, 2018.ResultsTwenty‐nine trials met the criteria and were reviewed. They included a total of 3226 patients across all trials. Thirty‐seven primary outcomes and 83 secondary outcomes were found. These were categorized into PIC‐related outcomes (infection, intensive care dependency, organ dysfunction, and mortality) and nutrition outcomes (energy targets, nutrition parameters, and feeding tolerance). We found large variation in the outcome measures used. Outcome domains of energy targets, feeding tolerance, and infection were not adequately defined.ConclusionsConsiderable variation in the outcome measures chosen and their definitions exist within PIC nutrition trials. Optimal nutrition outcomes for PIC must be agreed upon and defined, specifically domains of nutrition efficiency, nutrition tolerance, and non‐nutrition PIC outcomes. The next step is to conduct an international Delphi study to gain expert consensus and develop a core outcome set to be reported in future pediatric nutrition trials.
Evaluation of recurrence of periodontal disease after treatment in obese and normal weight patients: Two‐year follow‐up
Authors: Zuza Elizangela C. , Pires Juliana R. , de Almeida Ana Alice , Toledo Benedicto E. C. , Guimaraes‐Stabili Morgana R. , Junior Carlos Rossa , Barroso Eliane M. 
Published: February 2020

AbstractBackgroundObesity may represent a chronic low‐grade inflammation, but there is a lack of long‐term longitudinal studies. The aim of this longitudinal study was to evaluate the recurrence of periodontal disease in obese and normal weight patients submitted to scaling and root planing.MethodsThe study included 22 patients who had received periodontal treatment 2 years previously, 13 obese and nine non‐obese. The patients were evaluated for anthropometric measurements of body mass index, waist circumference, waist‐to‐hip ratio, and fat percentage through bioimpedance. The following periodontal parameters were recorded: visible plaque index (VPI), gingival bleeding index (GBI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). The immunological evaluation analyzed the proinflammatory cytokines interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐alpha (TNF‐α) in the gingival crevicular fluid (GCF).ResultsObese and normal weight patients did not differ in relation to the periodontal parameters of VPI, GBI, PD, CAL, or BOP 2 years after completion of the periodontal therapy. Sites with periodontitis in obese individuals showed higher levels of IL‐6 and TNF‐α in the gingival fluid (P <0.05).ConclusionObese and normal weight individuals had similar periodontal behaviors, with low recurrence of the periodontal disease; however, obesity was related to increased inflammatory activity in gingival fluid, which may become a risk indicator for future greater recurrence of the disease in the presence of inadequate plaque control.
Elevated viscosities in a simulated moving bed for γ‐aminobutyric acid recovery
Authors: Schultze‐Jena A. , Boon M.A. , Vroon R.C. , Bussmann P.J.Th. , Janssen A.E.M. , van der Padt A. 
Published: February 2020

AbstractProcess streams of agro‐food industries are often large and viscous. In order to fractionate such a stream the viscosity can be reduced by either a high temperature or dilution, the former is not an option in case of temperature sensitive components. Such streams are diluted prior to chromatographic fractionation, resulting in even larger volumes and high energy costs for sub‐sequential water removal. The influence of feed viscosity on the performance of simulated moving bed chromatography has been investigated in a case study of the recovery of a γ‐aminobutyric acid rich fraction from tomato serum. This work addresses the chromatographic system design, evaluates results from a pilot scale operation, and uses these to calculate the productivity and water use at elevated feed concentration. At the two higher feed viscosities (2.5 and 4 mPa·s) water use is lower and productivity higher, compared to the lowest feed viscosity (1 mPa·s). The behavior of the sugars for different feed viscosities can be described well by the model using the ratio of feed to eluent as dilution factor. The behavior of γ‐aminobutyric acid is highly concentration dependent and the recovery could not be accurately predicted.
Obstetrics and Gynecology Residents Can Accurately Classify Benign Ovarian Tumors Using the International Ovarian Tumor Analysis Rules
Authors: Sebajuri Jean Marie Vianney , Magriples Urania , Small Maria , Ntasumbumuyange Diomede , Rulisa Stephen , Bazzett‐Matabele Lisa 
Published: February 2020

ObjectivesRecognition of benign versus malignant tumors is essential in gynecologic ultrasound (US). The International Ovarian Tumor Analysis (IOTA) rules have been proposed as part of resident US training. The objective of this study was to examine whether they could be accurately used by obstetrics and gynecology residents in Rwanda.MethodsPatients undergoing explorative laparotomy for adnexal masses at the University Teaching Hospital of Kigali were included. Before the study, a didactic lecture on the IOTA rules for classifying adnexal masses was performed. Preoperative transabdominal US examinations were performed by residents at different levels of training, who were blinded to the results of prior US examinations. The IOTA classification was compared to the final pathologic diagnosis.ResultsThere were 72 patients who underwent 116 US examinations. Only 15.5% of US examinations were considered inconclusive. First‐year residents (12) correctly diagnosed 18 of 20 masses (90%) as benign and 4 of 4 as malignant. Second‐year residents (9) classified 29 of 29 masses correctly. Third‐year residents (10) accurately identified 21 of 22 (95.5%) as benign and 5 of 5 as malignant. Fourth‐year residents (13) accurately identified 11 of 12 (91.7%) as benign and 6 of 6 as malignant. Therefore, 74 of 78 tumors (94.9%) considered benign by IOTA rules were confirmed by histologic results. Similarly, all 20 tumors classified as malignant were confirmed. Overall, the sensitivities to diagnose benign and malignant tumors by the IOTA rules were 83.3% and 100%, respectively. The positive and negative predictive values were 100% and 94.9%. There were no significant differences noted between residency years.ConclusionsAll levels of Rwandan obstetrics and gynecology residents were able to use the IOTA rules to accurately distinguish benign from malignant tumors.
Compliance of clinical microbiology laboratories with recommendations for the diagnosis of bloodstream infections: Data from a nationwide survey in Italy
Authors: Arena Fabio , Argentieri Marta , Bernaschi Paola , Fortina Giacomo , Kroumova Vesselina , Pecile Patrizia , Rassu Mario , Spanu Teresa , Rossolini Gian Maria , Fontana Carla 
Published: February 2020

AbstractIn 2014, the Italian Working Group for Infections in Critically Ill Patient of the Italian Association of Clinical Microbiologists updated the recommendations for the diagnostic workflow for bloodstream infections (BSI). Two years after publication, a nationwide survey was conducted to assess the compliance with the updated recommendations by clinical microbiology laboratories. A total of 168 microbiologists from 168 laboratories, serving 204 acute care hospitals and postacute care facilities, were interviewed during the period January–October 2016 using a questionnaire consisting of nineteen questions which assessed the level of adherence to various recommendations. The most critical issues were as follows: (a) The number of sets of blood cultures (BC) per 1,000 hospitalization days was acceptable in only 11% of laboratories; (b) the minority of laboratories (42%) was able to monitor whether BCs were over or under‐inoculated; (c) among the laboratories monitoring BC contamination (80%), the rate of contaminated samples was acceptable in only 12% of cases;(d) the Gram‐staining results were reported within 1 hr since BC positivity in less than 50% of laboratories. By contrast, most laboratories received vials within 2–4 hr from withdrawal (65%) and incubated vials as soon as they were received in the laboratory (95%). The study revealed that compliance with the recommendations is still partial. Further surveys will be needed to monitor the situation in the future.