bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of CRP, PCT, N%, Bell stage and add milk the day before onset of NEC for predicting surgical necrotizing enterocolitis and their clinical significance
Authors: Wang Li , Huang Jingwei , Wang Lili 
Published: November 2019

Abstract
Objects Necrotizing enterocolitis (NEC) is a severe neonatal disease. The present study aimed to identify risk factors of NEC and predict surgical NEC.Methods According to the modified Bell’s staging criteria, 235 neonates with NEC admitted between Jan 1, 2015 and Sep 30, 2019 were divided into surgical group (n=47) and conservative group (n=188). Data concerning clinical characteristics and therapeutic management were collected. Infection values of WBC, N%, PLT, CRP, PCT were measured before treatment (T0), on the next day after treatment (T1).Results 1. Surgical group were associated with gestational age, small for gestational age, add milk before onset of NEC, hospitalization expense compared to conservative group (p=0.040, 0.048, 0.045, 0.011), in addition to N%0, N%1, PLT1, CRP1 and PCT1 (p=0.049, 0.003, 0.018, <0.001, 0.003). There was significant difference in NEC among Bell stage I, II and III between surgical group and conservative group (χ2=49.358, p<0.001). 2. Regression analysis showed that Bell stage I, II and III NEC (OR 12.331, 6.315, p=0.038, 0.025), N%1 (OR 0.959, p=0.032), CRP1 (OR 0.978, p=0.039) and PCT1 (OR 0.983, p=0.036), add milk before onset of NEC (OR 7.117, p=0.021) were all independent risk factors to predict surgical NEC. 3. The AUC of combined Bell stage I, II and III NEC, N%1, CRP1, PCT1, add milk the day before onset of NEC (P) in predicting surgical NEC was 0.924 (95%CI 0.865~0.983, p<0.001). The ideal cutoff value of P was 0.729, with a sensitivity of 85.7% and specificity of 87.5%.Conclusion Increased Levels of CRP1, PCT1, N%1, Bell stage I, II and III, and add milk the day before onset of NEC are all independent risk factors of NEC, and combined of them can be used to predict the development of surgical NEC.
Soybean Phenology Prediction Tool for the US Midsouth
Authors: dos Santos Caio , Salmerón Montserrat , Purcell Larry C. 
Published: November 2019

Core Ideas
Soybean phenology predictions allow producers to schedule management decisions.
Phenology can be predicted for a location and maturity group from temperature and photoperiod.
Predictions from 2776 locations were generated for the US Midsouth.
An interactive map displays predicted dates of flowering, beginning seed fill, and physiological maturity.
Eco‐physiology models can predict soybean [Glycine max (L.) Merrill] development by describing daily development as a function of temperature, photoperiod, and cultivar sensitivity to these environmental conditions. However, these models require calibration with field data and a skilled user, limiting their agronomic application and adoption. We developed an interactive forecasting tool (SoyStage) using algorithms and previously calibrated coefficients from DSSAT‐CROPGRO‐Soybean. SoyStage predicts dates of first flower, beginning seed fill, and physiological maturity for emergence dates ranging from 14 March to 27 June in 7‐d intervals, maturity groups (MGs) 3.2 to 6.7 in one‐half MG increments, and 2776 locations across the US Midsouth based on weather data from 1981 to 2016. Predictions from SoyStage agreed well with field observed phenological stages monitored at 27 site‐years (RMSE ≤ 7.2 d). SoyStage can be accessed through the internet, requiring minimal inputs and predicting phenology for a wide range of locations, MGs, and emergence dates.
Monitoring Soil Water Content Using Time‐Lapse Horizontal Borehole GPR Data at the Field‐Plot Scale
Authors: Klotzsche Anja , Lärm Lena , Vanderborght Jan , Cai Gaochao , Morandage Shehan , Zörner Miriam , Vereecken Harry , van der Kruk Jan 
Published: November 2019

Core Ideas
4‐yr monitoring of soil water content dynamics for different plant types.
Horizontal crosshole GPR at the field‐plot scale sampled ∼65 m3.
Natural, irrigated, and sheltered treatments in gravelly and clayey–silty soils.
Consistent patches of soil water content were observed along horizontal slices using GPR.
Results enable improved investigation of soil–plant–atmosphere interactions.
Ground penetrating radar (GPR) has shown a high potential to derive soil water content (SWC) at different scales. In this study, we combined multiple horizontal GPR measurements at different depths to investigate the spatial and temporal variability of the SWC under cropped plots. The SWC data were analyzed for four growing seasons between 2014 and 2017, two soil types (gravelly and clayey–silty), two crops (wheat [Triticum aestivum L.] and maize [Zea mays L.]), and three different water treatments. We acquired more than 150 time‐lapse GPR datasets along 6‐m‐long horizontal crossholes at six depths. The GPR SWC distributions are distinct both horizontally and vertically for both soil types. A clear change in SWC can be observed at both sites between the surface layer (>0.3 m) and subsoil. Alternating patches of higher and lower SWC, probably caused by the soil heterogeneity, were observed along the horizontal SWC profiles. To investigate the changes in SWC with time, GPR and time‐domain reflectometry (TDR) data were averaged for each depth and compared with changes in precipitation, treatment, and soil type. The high‐temporal‐resolution TDR and the large‐sampling‐volume GPR show similar trends in SWC for both sites, but because of the different sensing volumes, different responses were obtained due to the spatial heterogeneity. A difference in spatial variation of the crosshole GPR SWC data was detected between maize and wheat. The results for this 4‐yr period indicate the potential of this novel experimental setup to monitor spatial and temporal SWC changes that can be used to study soil–plant–atmosphere interactions.
Solar water disinfection with parabolic and flat reflectors
Authors: Beattie Audrey , Dillon Heather , Poor Cara , Kenton Ryan 
Published: November 2019

Abstract
Solar water disinfection (SODIS) is a process by which microbially contaminated water is disinfected by transmitting solar ultraviolet radiation to the water, rendering the bacteria inactive. The purpose of this project was to determine a residence time for disinfection in specific applications using a 3-log reduction in colony-forming units per milliliter (CFU/mL). The water was contained in quartz tubes and tested over both flat and parabolic reflectors. While UVA and UVB radiation are diffuse and independent of reflector style, water temperature is affected by solar concentration. The two reflector styles were studied to identify how insolation level and temperature affects the bacteria inactivation process. Escherichia coli, DH5α, was inoculated into sterile water and treated for 2, 4, and 8 h. The study had several conclusions, first that a 5-log reduction was achieved after 2 h, for all water temperature and insolation levels. The reflector style did not have a measurable effect on inactivation due to the short disinfection time, but the water temperature increased significantly with the parabolic reflectors. A thermal model of the two systems confirmed that the parabolic configuration resulted in higher energy input, making it the preferred configuration for disinfection with lower residence times.
Metabolic Alterations in the Outer Membrane Vesicles of Patients with Alzheimer’s Disease: An LC-MS/MS-based Metabolomics Analysis
Authors: Wei Shou-Chao , Wei Wei , Peng Wan-Juan , Liu Zhou , Cai Zhi-You , Zhao Bin 
Published: November 2019

Objective:To characterize the specific metabolomics profiles in the outer membrane vesicles (OMVs) of patients with Alzheimer’s Disease (AD) and to explore potential metabolic biomarkers and their diagnostic roles.Methods:Nine AD patients and age- and sex-matched healthy controls were enrolled, and feces were collected. OMVs were extracted, purified, and then analyzed using liquid chromatography-tandem mass chromatography (LC-MS/MS) method coupled with a series of multivariate statistical analyses.Results:Remarkable differences were found between the OMVs from AD patients and those from healthy controls. A number of differential metabolites and several top-altered metabolic pathways were identified. The levels of aspartate, L-aspartate, imidazole-4-acetate and L-glutamate were confirmed to be highly upregulated in AD-OMVs. Other differential metabolites, such as arachidic acid, prostaglandin G2, and leukotriene B4, were also identified. Furthermore, the differential metabolites possessed higher areas under the ROC curve (AUCs).Conclusion:Metabolic activity is significantly altered in the OMVs from AD patients. This data might be helpful for identifying novel biomarkers and their diagnostic roles in AD.:Furthermore, OMVs metabolomics analysis combined with GWAS could enrich our understanding of the genetic spectrum of AD and lead to early predictions and diagnosis and clinical applications of better AD treatments.
Salivary mir-27b Expression in Oral Lichen Planus Patients: A Series of Cases and a Narrative Review of Literature
Authors: Stasio Dario Di , Mosca Laura , Lucchese Alberta , Cave Donatella Delle , Kawasaki Hiromichi , Lombardi Angela , Porcelli Marina , Caraglia Michele 
Published: November 2019

Background:
microRNAs play a critical role in auto-immunity, cell proliferation, differentiation
and cell death. miRNAs are present in all biological fluids, and their expression is essential in
maintaining regular immune functions and preventing autoimmunity, whereas miRNA dysregulation
may be associated with the pathogenesis of autoimmune and inflammatory diseases. Oral lichen planus
(OLP) is an inflammatory disease mediated by cytotoxic T cells attack against epithelial cells. The
present study aims to perform a specific microRNA expression profile through the analysis of saliva in
this disease.

Methods:
The study group was formed by five patients (mean age 62.8±1.98 years; 3 females/2 males)
affected by oral lichen planus and control group by five healthy subjects (mean age 59.8 years±2.3; 3
females/ 2 males); using a low-density microarray analysis, we recorded a total of 98 differentially
expressed miRNAs in the saliva of patients with oral lichen planus compared to the control group. The
validation was performed for miR-27b with qRT-PCR in all saliva samples of oral lichen planus group.

Results:
89 miRNAs were up-regulated and nine down-regulated. In details, levels of miR-21, miR-
125b, miR-203 and miR15b were increased (p<0.001) in study group while levels of miR-27b were
about 3.0-fold decreased compared to controls (p<0.001) of miR-27b expression in OLP saliva. QRTPCR
validation confirmed the down regulation of miR-27b in all saliva samples.

Conclusions:
Collecting saliva samples is a non-invasive procedure and is well accepted by all patients.
microRNAs can be readily isolated and identified and can represent useful biomarkers of OLP.
A Stiff Person Syndrome Misdiagnosed as a Psychiatric Illness: A Case Report
Authors: Souissi Mohamed-Anis , Bellakhal Syrine , Gharbi Emna , Abdelkefi Istabrak , Douggui Mohamed-Hedi 
Published: November 2019

Background:
Stiff Person Syndrome (SPS) is a rare autoimmune neurological disorder
which is often misdiagnosed. We report here a case of SPS with a long diagnosis delay.

Case:
A 36-year-old man presented with an 11-year history of progressive stiffness and painful
spasms of his both legs, with recent worsening of his condition over the last year resulting in a considerable
difficulty of standing up and walking. As the patient developed phobic symptoms, he was
considered as having a psychiatric illness and treated with antianxiety and antidepressant drugs. As
no real improvement was observed, the patient was referred to internal medicine. Neurological examination
showed paraspinal, abdominal and lower limbs muscle contraction with lumbar rigidity.
These symptoms were associated to adrenergic symptoms: profuse sweating, tachycardia and high
bloodpressure. Initial routine investigations revealed high blood glucose level. Polygraphic electromyographic
(EMG) evaluation from paraspinal and leg muscles showed continuous motor unit
activity in agonist and antagonist muscle. Electroencephalography and brain magnetic resonance
imaging were normal. Immunologic tests according to radio immune assay technique revealed high
level of serum anti-glutamic acid decarboxylase (anti-GAD65) antibodies. Diagnosis of autoimmune
SPS was retained based on clinical, electrophysiological, and immunological findings. Pregabalin
at the dose of 150 mg, three times a day was prescribed with satisfying response.

Conclusion:
SPS is supported by an autoimmune pathogenesis and anti-GAD antibodies seems to
be very helpful when SPS is clinically suspected. Treatment of SPS is a challenge, given the scarcity
of the syndrome and the absence of established recommendations.
Characteristics and Risk Factors Associated with Stroke Subtypes among Adult Patients Admitted to the Stroke Unit of Jimma University Medical Center: A Retrospective Cross-sectional Study
Authors: Gebreegziabher Bekalu G. , Birhanu Tesema E. , Olana Diriba D. , Tesfaye Behailu T. 
Published: November 2019

Background:
Almost 80% of deaths due to non-communicable diseases occur in lowand
middle-income countries. Stroke is a great public health problem in Ethiopia. Stroke mortality
was estimated to be 14.7% in Ethiopia. Despite this, researches done in Ethiopia on factors associated
with stroke sub-types were inadequate.

Objective:
To assess the characteristics and risk factors associated with stroke subtypes among patients
admitted to Jimma University Medical Center.

Methods and materials:
A retrospective cross-sectional study was conducted from May 2017 to
May 2018 in the stroke unit of the Jimma University Medical Center. A total of 106 medical charts of
patients diagnosed with stroke were reviewed. A checklist comprising relevant variables was used
to collect data. SPSS version 21 was employed for data entry and analysis. Pearson chi-square test was
used to check the association of different parameters with stroke subtypes. A P-value <0.05 was used
as a cutoff point to declare statistical significance. Data were presented using text, tables, and figures.

Result:
From a total of 106 patients, 67 (63.2%) were men. The mean ± SD of age was
52.67±12.46 Year's, and the difference was not significant among stroke subtypes. Among all patients,
59 (55.6%) had ischemic strokes and 47 (44.4%) had hemorrhagic strokes. The most prevalent
risk factors significantly associated with stroke subtypes were being male 67 (63.2%) followed
by dyslipidemia 43 (40.5%) and cigarette smoking 38 (35.8%).

Conclusion:
The ischemic stroke was reported to be higher than hemorrhagic in this study. The
overall mean (±SD) age of the patient was 52.67±(12.46) years. The mean age of hemorrhagic
stroke patients was 55.98 (±13.77) years; while in ischemic stroke was 50.03 (±10.70) years. Being
male, a history of cigarette smoking, and dyslipidemia were significantly associated with stroke
subtypes.
Atypical Takotsubo Cardiomyopathy with Hypokinetic Left Mid-ventricle and Apical Wall Sparing: A Case Report and Literature Review
Authors: Ludhwani Dipesh , Sheikh Belaal , Patel Vasu K , Jhaveri Khushali , Kizilbash Mohammad , Sura Prashant 
Published: November 2019

Background:
Takotsubo Cardiomyopathy (TTC) is an uncommon cause of acute reversible
ventricular systolic dysfunction in the absence of obstructive Coronary Artery Disease
(CAD). Typically manifesting as apical wall ballooning, TTC can rarely present atypically with
apical wall sparing.

Case report:
A 62-year-old female presented with complaints of chest pain and features mimicking
acute coronary syndrome. Coronary angiogram revealed no obstructive CAD and left ventriculogram
showed reduced ejection fraction, normal left ventricular apex and hypokinetic mid-ventricles
consistent with atypical TTC. The patient was discharged home on heart failure medications and a
follow-up transthoracic echocardiogram demonstrated improved left ventricular function with no
wall motion abnormality.

Conclusion:
This case report provides an insight into the diagnosis and management of TTC in the
absence of pathognomic features.
An RP-HPLC Method for Quantitative Analysis of Linagliptin Entrapped in Nanotransfersomes and its Application to Skin Permeation Studies
Authors: Peram Malleswara Rao , Patil Sachin R. , Kumbar Vijay M. , Kugaji Manohar S. , Bhat Kishore G. , Diwan Prakash V. , Jalalpure Sunil 
Published: November 2019

Background:Linagliptin (LNG) is an oral hypoglycemic agent that acts by inhibiting the enzyme dipeptidyl peptidase - 4 (DPP-4) and reduces blood sugar levels in type-II diabetic patients. To date, the literature presents few analytical methods for the determination of LNG. However, no reversed phase-high performance liquid chromatography (RP-HPLC) method has been reported for the determination of LNG in nanotransfersomes and in vitro skin permeation samples.Objective:The present study involves the development and validation of RP-HPLC method to quantify LNG in both nanotransfersomes and in vitro skin permeation and deposition samples.Methods:The chromatographic analysis was performed on Luna C18 (2) column (250 x 4.6 mm, 5μm particle size) with a mobile phase consisting of a mixture of methanol: 0.2% orthophosphoric acid (50:50, v/v) at a flow rate of 1.0 mL/min, detection wavelength of 227 nm, and column temperature of 40 °C.Results:The method was found to be specific, linear (r2≥ 0.999; 2-12 μg/mL), precise at both intra and inter-day levels (percentage relative standard deviation; % RSD < 2.00), accurate (percentage recovery 100.21-103.83%), and robust. The detection and quantification limits were 0.27 and 0.82 μg/mL, respectively. The mean % entrapment efficiency and the cumulative amount of LNG permeated across the rat skin from different transfersomal formulations ranged between 40.78 ± 2.54 % to 52.26 ± 2.15 % and 79.54 ± 16.67 to 200.74 ± 35.13 μg/cm2respectively.Conclusion:The method was successfully applied to determine the entThe method was successfully applied to determine the entrapment efficiency, in vitro skin permeation and deposition behavior of LNG-nanotransfersomes.rapment efficiency, in vitro skin permeation and deposition behavior of LNG-nanotransfersomes.
The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Omidian Mahsa , Abdolahi Mina , Daneshzad Elnaz , Sedighiyan Mohsen , Aghasi Mohadeseh , Abdollahi Hamed , Omidian Parisa , Dabiri Sasan , Mahmoudi Maryam 
Published: November 2019

Objective:
Recent trial studies have found that resveratrol supplementation beneficially
reduces oxidative stress marker, but, there is no definitive consensus on this context. The present systematic
review and meta-analysis aimed to investigate the effect of resveratrol supplementation on
oxidative stress parameters.

Methods:
We searched databases of Pubmed, Scopus and Cochrane Library up to December 2018 with
no language restriction. Studies were reviewed according to preferred reporting items for systematic
reviews and meta-analyses (PRISMA) and Cochrane handbook. To compare the effects of resveratrol
with placebo, weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled
based on the random-effects model.

Results:
Among sixteen clinical trials, we found that resveratrol supplementation increased GPx serum
levels significantly (WMD: 18.61; 95% CI: 8.70 to 28.52; P<0.001) but had no significant effect on
SOD concentrations (WMD: 1.01; 95% CI: -0.72 to 2.74; P= 0.25), MDA serum levels (WMD: -1.43;
95% CI: -3.46 to 0.61; P = 0.17) and TAC (WMD: -0.09; 95% CI: -0.29 to 0.11; P = 0.36) compared to
placebo. Finally, we observed that resveratrol supplementation may not have a clinically significant
effect on oxidative stress.

Conclusion:
However, the number of human trials is limited in this context, and further large prospective
clinical trials are needed to confirm the effect of resveratrol supplement on oxidative stress
markers.
Fault Diagnosis Method of Mine Motor Based on Support Vector Machine
Authors: Zhang Yan , Sheng Ren 
Published: November 2019

Background:
In order to improve the efficiency of fault treatment of mining motor, the
method of model construction is used to construct the type of kernel function based on the principle
of vector machine classification and the optimization method of parameters.

Methodology:
One-to-many algorithm is used to establish two kinds of support vector machine
(SVM) models for fault diagnosis of motor rotor of crusher. One of them is to obtain the optimal
parameters C and g based on the input samples of the instantaneous power fault characteristic data
of some motor rotors which have not been processed by rough sets. Patents on machine learning
have also shows their practical usefulness in the selction of the feature for fault detection.

Results:
The results show that the instantaneous power fault feature extracted from the rotor of the
crusher motor is obtained by the cross validation method of grid search k-weights (where k is 3) and
the final data of the applied Gauss radial basis penalty parameter C and the nuclear parameter g are
obtained.

Conclusion:
The model established by the optimal parameters is used to classify and diagnose the
sample of instantaneous power fault characteristic measurement of motor rotor. Therefore, the classification
accuracy of the sample data processed by rough set is higher.
Non-Destructive Tests on Carpentry Steels
Authors: Formisano Antonio , Dessì Enzo Jr. , Chiumiento Giovanni 
Published: November 2019

Background:
Industrial archaeology represents a modern branch of urbanism and architecture that studies, applying an interdisciplinary method, all the evidence inherent the process of industrialization from its origins to the actuality.

Aim:
Looking at the cities of our epoch, more and more are the testimonies of these historical artefacts, which in fact represent our cultural identity and are often intended to be recovered and converted into modern destinations of use.

Methods:
If the identification of constructive schemes is based on direct essays and surveys, the definition of material properties requires material testing and investigation. For metal structures, the standards involve destructive investigations only, with a sampling of specimens, which often conflict with the protection requirements of the artefact. This leads to the need to refine and make reliable non-destructive investigations using the Leeb method, by means of portable micro-durometers, for in-situ characterization of carpentry steels, so to suggest new regulatory guidelines for existing structures surveys.

Results:
In the paper, the classification of carpentry steels based on non-destructive hardness test was illustrated and discussed. Firstly, for the evaluation of the resistance class of a structural steel, it was recorded that the execution of tests required a careful cleaning of the surface of samples.
Subsequently, analyzing the data obtained from the experimentation, it was clear that the best methodology of data conversion from micro-hardness (Leeb method) tests for the determination of the steel class was given by tables and formulations of the ASTM standard. In the case of a few values to be converted, the most effective method was the manual use of the tables, with an average error of 0.10%.

Conclusion:
In conclusion, it should be remarked that differently from the reinforced concrete structures, where the non-destructive tests are allowed by the current Italian technical code on, for metallic structures only, destructive tests are permitted, so that the use of non-destructive ones should be encouraged, especially when interventions on cultural heritage constructions are of concern.