bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Carbohydrate and Low Fat Diets with Equal Protein Content Lead to Similar Improvements in Body Composition and Glucose Tolerance in Obese Mice subjected to Caloric Restriction
Authors: Minderis Petras , Fokin Andrej , Dirmontas Mantas , Ratkevicius Aivaras 
Published: November 2019

AbstractBackgroundReported differences in effects of low and high carbohydrate diets on weight control and metabolic health are controversial. We aimed to examine if such diets induce different improvements in body composition and glucose tolerance under conditions of caloric restriction (CR) in obese mice.MethodsMale C57BL/6J mice (n = 20) were fed obesogenic diet (45 and 17.5% kcal from fat and sugar)ad libitumfor 18 weeks and then subjected to 6-week CR which progressively increased up to 40% using either Low Fat diet (20, 60, 20% kcal from fat, carbohydrate, protein, n = 10) or Low Carb diet (20, 60, 20% kcal from carbohydrate, fat, protein, n = 10). Mice fed regular chow dietad libitumserved as controls (n = 10). Body mass, hind limb muscle mass, fat mass, energy expenditure and glucose tolerance were compared between the groups.ResultsLow Fat and Low Carb groups had similar body mass (p> 0.05) prior to CR which was 30% greater compared to control group (p< 0.001). CR resulted in weight loss with no differences between Low Fat and Low Carb groups (30.0 ± 5.6 and 23.8 ± 7.5%,p> 0.05). Weight loss was mainly due to fat loss in both groups. Energy expenditure of freely moving mice did not differ between the groups (p> 0.05). Intraperitoneal glucose tolerance test improved compared to control group (p< 0.05) and values before CR (p< 0.01) but without differences between Low Fat and Low Carb groups (p> 0.05).ConclusionsDietary carbohydrate or fat content when protein is equated does not play a significant role for body composition and metabolic health benefits of caloric restriction in obese mice.
Visual Analytics for Deep Embeddings of Large Scale Molecular Dynamics Simulations
Authors: Chae Junghoon , Bhowmik Debsindhu , Ma Heng , Ramanathan Arvind , Steed Chad 
Published: November 2019

AbstractMolecular Dynamics (MD) simulation have been emerging as an excellent candidate for understanding complex atomic and molecular scale mechanism of bio-molecules that control essential bio-physical phenomenon in a living organism. But this MD technique produces large-size and long-timescale data that are inherently high-dimensional and occupies many terabytes of data. Processing this immense amount of data in a meaningful way is becoming increasingly difficult. Therefore, specific dimensionality reduction algorithm using deep learning technique has been employed here to embed the high-dimensional data in a lower-dimension latent space that still preserves the inherent molecular characteristics i.e. retains biologically meaningful information. Subsequently, the results of the embedding models are visualized for model evaluation and analysis of the extracted underlying features. However, most of the existing visualizations for embeddings have limitations in evaluating the embedding models and understanding the complex simulation data. We propose an interactive visual analytics system for embeddings of MD simulations to not only evaluate and explain an embedding model but also analyze various characteristics of the simulations. Our system enables exploration and discovery of meaningful and semantic embedding results and supports the understanding and evaluation of results by the quantitatively described features of the MD simulations (even without specific labels).
Strategic alignment of project management with health, safety and environmental management
Authors: Ershadi Mohammad Javad , Edrisabadi Reza , Shakouri Aghileh 
Published: November 2019

Purpose
Project management generally covers many important areas such as cost, quality and time in different industrial settings, but it is deficient in relation to integration of health, safety and environmental risks. Poor knowledge of project managers about HSE management necessitates the studying on the mutual effects of HSE and project management. Hence, investigating the impact of project management on health monitoring programs, safety prevention monitoring, environmental monitoring plans and finally the effectiveness of professional health monitoring programs and determining their importance are main objectives of this research. The paper aims to discuss these issues.

Design/methodology/approach
A model based on structural equations was designed and developed. The constructs of this model are project management, health monitoring and safety prevention monitoring program. Based on the conceptual model, some questionnaires were prepared and distributed among the experts of strategic project management.

Findings
The results of applied structural modeling suggest that project management focuses on each aspect of HSE management, including health monitoring programs, safety prevention monitoring programs, environmental monitoring plans and effectiveness of professional health monitoring programs. HSE management can also be strengthened by empowering project management. Checking fire protection systems, using appropriate techniques to identify contamination and disposal of waste and incorporating techniques for brainstorming or other ideas creation in the group are the most important tasks in HSE-enabled project management frameworks.

Originality/value
Since there is still no strategic alignment model that includes components of project management and HSE management, a model for achieving this goal is vital. This paper elaborates this alignment based on literature and using a field study.
Yuppiechef: from clicks to bricks – an omnichannel approach for a South African business
Authors: Reyneke Mignon , Barnardo Claire 
Published: November 2019

Learning outcomes
The learning outcomes are as follows: understanding online, traditional and omnichannel retail and the challenges and benefits of each method; evaluating the effect of consumer buying behaviour on a company’s growth strategy; assessing the effect of changing industry dynamics and technology on consumer behaviour; and understanding the role of consistent customer experience across different retail mediums.

Case overview/synopsis
This case looks at Yuppiechef, a successful e-commerce business, and their move from “clicks to bricks” with the introduction of retail stores. Founder and CEO of Yuppiechef, Andrew Smith, shares the current business status and considers how to maintain the brand’s culture with the growth of retail and being an omnichannel pioneer.

Complexity academic level
The primary target audience for this teaching case is postgraduate business students, especially students of digital marketing, strategy and e-commerce. This teaching case is intended to be used as case study in postgraduate business programmes such as Master of Business Administration (MBA), a specialist masters’ programme such as MM (Entrepreneurship), post-graduate diploma in management (PGDip), as well as selected executive education programmes.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 8: Marketing.
Drink the Duchess: marketing challenges and opportunities encountered when SMEs internationalise
Authors: Bick Geoff , Heathcote Fran 
Published: November 2019

Learning outcomes
The learning outcomes are as follows: first, identify the characteristics of born-global SMEs, and how these characteristics facilitate their global expansion shortly after the company’s inception. Second, demonstrate that companies work with limited resources, typically and notably newly established companies, and that these resources should be allocated according to a carefully determined strategy. The resources focussed on in this case pertain to marketing. Third, examine entrepreneurial marketing and its various manifestations. An understanding of how this type of marketing is used by companies for international expansion is expected. Fourth, assess the role of digital marketing and how social media forms an important part of digital marketing. Particular attention is paid to the use of digital marketing, notably social media, in international expansion. Fifth, develop critical thinking skills with respect to strategic business decisions, such as whether to expand a business into foreign markets or to consolidate locally; and how best to penetrate foreign markets, given the nuances and complexities specific to these markets.

Case overview/synopsis
This teaching case is about The Duchess, a recently developed and launched virgin alcohol-free and sugar-free gin and tonic beverage. The adult soft drink was originally launched in South Africa, and just 18 months later became available in international markets (the UK and Belgium). The founders and protagonists of the case, Johannes le Roux and Inus Smuts, face the dilemmas of creating a competitive local brand while also looking to access new markets and internationalise as a born-global firm.

Complexity academic level
The target audience for this case comprises students enrolled in tertiary business education programmes who have already had some sort of work experience and hands-on exposure to real-world business. MBA and EMBA students, as well as those enrolled in post-graduate studies specific to marketing, international commerce and entrepreneurship, would be suitable candidates.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing
Understanding the Chinese information culture and its impact on IT perceptions
Authors: Chen Leida , Zhang Xiaohan , Li Zhensheng 
Published: November 2019

PurposeDrawing upon the theory of information culture from information science and prior research on Chinese information practices. The purpose of this paper is to posit that instead of over-relying on Hofstede’s national cultural values, the IS field should develop theories on national information culture to bridge the theoretical gaps found in explaining the differences in individuals’ IT perceptions and behaviors across cultures.Design/methodology/approachTo achieve the objectives of this study, two quantitative studies were conducted. The first study is exploratory in nature and focuses on the development and calibration of an instrument to measure the Chinese information culture (CIC). The second study takes a confirmatory approach to investigate the impact of the CIC on IT perceptions of manager.FindingsThe study develops and validates an instrument for measuring the CIC that comprises information source and format preference, information ownership and analysis style, and centralized decision-making and information control. The CIC is found to influence IT perceptions of managers including perceived performance improvement resulted from IT use, attitude toward using work technologies and attitude on the value of IT in general.Originality/valueThis study is one of the first studies to theorize national information culture to understand IT perceptions at the individual level. The development of the CIC measure provides the much needed methodological support for contextualizing cross-cultural research.
A longitudinal analysis for informativeness of earnings announcements in Borsa Istanbul
Authors: Ahlatcioglu Aykut , Okay Nesrin 
Published: November 2019

PurposeThe purpose of this paper is to assess the information value of earnings announcements for the 2007–2017 period in Borsa Istanbul.Design/methodology/approachAbnormal volatility (AVOL) and abnormal absolute return (AAR) in the three-day window around the earnings announcement are used as proxies for information content. A pooled regression of AVOL and AAR is conducted to test for the existence of information content and analyze its time trend along with its determinants.FindingsThe authors find significantly positive AVOL and AAR which shows that earnings have information content for investors during the sample period. Furthermore, both proxies demonstrate a positive time trend after controlling for various firm characteristics and surprise measures. The authors take this as evidence that overall informativeness of earnings has increased over time. The authors observe that this increase is most prevalent for growth companies and earnings announcements with high absolute surprise. This study provides partial support for the hypothesis that value of earnings announcements has increased after an improvement in information dissemination technology with the inception of the online disclosure platform, KAP.Practical implicationsUnderstanding information value of earnings announcements is of interest for companies which prepare earnings reports, regulators who set standards on their content and frequency and investors which make investment decisions based on information released at these announcements.Originality/valueThere had been few non-US studies related to information value of earnings announcements. The overwhelming majority of these are conducted using limited data sets from the latter part of the last century and only analyze annual earnings announcements. The authors aim to shed light on the subject using a broad and recent sample of quarterly earnings announcements from a major emerging market, Turkey.
What has the Brexit Process done to Scotch Whisky?
Authors: Ichijo Atsuko 
Published: November 2019

AbstractThe United Kingdom’s membership of the European Union does not have any impact on Scotch whisky itself: Brexit or not, Scotch whisky is Scotch whisky. However, it features more prominently in the Brexit negotiations than, for example, beer. This is because Scotch whisky is a highly export‐oriented product which brings large economic benefits to the UK—particularly Scotland—and its brand is protected by the international regime of intellectual property rights protection, especially, by the geographical indications regime championed by the EU. Moreover, the Brexit negotiations have led to the resurfacing of another political issue which affects Scotch whisky: Scottish independence. As a strong territorial brand, the constitutional status of Scotland is highly relevant to Scotch whisky and the investigation into the impact of the Brexit process on Scotch whisky has highlighted the inter‐connectedness of various political issues.
A Test of the Theory of Planned Behavior in the Prediction of Alcohol‐Induced Blackout Intention and Frequency
Authors: DiBello Angelo M. , Miller Mary Beth , Merrill Jennifer E. , Carey Kate B. 
Published: November 2019

BackgroundThis study examined the theory of planned behavior (TPB) as an explanatory model for alcohol‐induced blackouts among college students. Blackouts are periods of time wherein individuals continue to function and engage in their social environment but do not remember it as a result of consuming large quantities of alcohol. Social cognitive factors posited within TPB, such as perceived norms and personal attitudes toward alcohol consumption, are reliable predictors of alcohol use and related problems. However, research to date has not examined these theoretical antecedents as predictors of alcohol‐induced blackout.MethodsCollege students with a history of blackout (N = 384) completed a baseline survey, and a subsample (N = 120) completed a 1‐month follow‐up survey. Negative binomial mediation models were used to evaluate intentions to blackout as a mediator of the norms, attitudes, and self‐efficacy to avoid blackout–blackout frequency association at baseline and 1‐month follow‐up.ResultsNorms, attitudes, and self‐efficacy to avoid blackout all significantly predicted blackout intentions at baseline, which in turn predicted more frequent blackouts both at baseline and at 1‐month follow‐up. Notably, blackout attitudes demonstrated both direct and indirect associations with blackout frequency.ConclusionsProspective analyses provided partial support for the TPB, with only attitudes and intentions demonstrating prospective associations with actual blackout frequency. Given the particularly strong association between blackout attitudes and frequency of blackouts, attitudes may represent an important and novel target for prevention and intervention efforts.
Dose‐dense chemotherapy for untreated poor‐prognosis and relapsed germ‐cell tumours: an 18‐year experience with GAMEC chemotherapy
Authors: Shamash Jonathan , Mee Matthew , Sarker Shah‐Jalal , Wilson Peter , Ansell Wendy , Greenwood Michelle , Berney Dan , Alifrangis Constantine 
Published: November 2019

ObjectiveTo report a single‐centre experience of the regimen GAMEC (granulocyte colony‐stimulating factor, actinomycin‐D, methotrexate with folinic acid rescue, etoposide and cisplatin) over 18 years in both untreated disease and relapse settings.MethodsThis retrospective cohort study was based on 162 patients who received GAMEC dose‐dense chemotherapy incorporating actinomycin and high dose methotrexate. Survival outcomes were compared. Risk categorization based on (1) the International Prognostic Factor Study Group (IPFSG) criteria and (2) two factors, lactate dehydrogenase (LDH) levels greater than the upper limit of normal and age ≥35 years, were also compared in terms of survival outcomes using Cox proportional hazard regression modelling.ResultsSeventy‐five patients with poor‐prognosis disease, according to International Germ Cell Cancer Collaborative Group classification, received GAMEC as initial therapy. With a median follow‐up of 63 months, the median progression‐free survival (PFS) was >14 months. The 2‐year PFS rate was 61.5% (95% confidence interval [CI] 49.1–71.6), and the 3‐year overall survival (OS) rate was 71.9%. Seventy‐six patients received GAMEC as second‐line therapy (following failure of bleomycin, etoposide and cisplatin or etoposide cisplatin). The median PFS was 7.5 months (95% CI 5.2–not evaluable), the 2‐year PFS rate was 43.5% (95% CI 32.1–54.4) and the 3‐year OS rate was 53.7% (95% CI 41.6–64.3). In the third‐line setting (n = 11), the 2‐year PFS was 18.2% (95% CI 2.8–44.2). Overall, the treatment‐related death rate declined from 10.5% in the first 15 years to 2.6% in the last 5 years.ConclusionGAMEC was an effective regimen in untreated poor‐prognosis disease and on relapse following conventional cisplatin and etoposide‐based chemotherapy. Risk categorization based on LDH/age is more sensitive than that based on the updated IPFSG criteria. It is possible to identify patients who are particularly likely to benefit from this treatment, which has the important advantages of short duration and absence of bleomycin, particularly in patients with central nervous system and mediastinal disease. Low‐dose induction treatment is associated with safer delivery of treatment without compromising survival.
Pain attenuating actions of vincristinet‐preconditioning in chemotherapeutic agent‐induced neuropathic pain: key involvement of T‐type calcium channels
Authors: Sharma Jasmine , Maslov Leonid N. , Singh Nirmal , Jaggi Amteshwar Singh 
Published: November 2019

AbstractPreconditioning is a well‐documented strategy that induces hepatic protection, renal protection, cardioprotection, and neuroprotection but its mechanism still remains to be elucidated. Hence, the present study investigated the protective mechanism underlying pain attenuating effects of vincristine‐preconditioning in chemotherapeutic agent‐induced neuropathic pain. Neuropathic pain was induced by administration of vincristine (50 µg/kg, i.p.) for 10 days in rats. Vincristine‐preconditioning was induced by administration of vincristine (2, 5, and 10 µg/kg, i.p) for 5 days before administration of pain‐inducing dose of vincristine (50 µg/kg, i.p.). Vincristine‐preconditioning (10 µg/kg, i.p) for 5 days significantly reduced vincristine (50 µg/kg, i.p.) induced pain‐related behaviors including paw cold allodynia, mechanical hyperalgesia, and heat hyperalgesia. However, vincristine (2 and 5 µg/kg, i.p) did not significantly ameliorate the vincristine (50 µg/kg, i.p.) induced neuropathic pain in rats. Furthermore, to explore the involvement of calcium channels in pain attenuating mechanism of vincristine‐preconditioning, T‐type calcium channel blocker, ethosuximide (100 and 200 mg/kg, i.p.) and L‐type calcium channel blocker, amlodipine (5 and 10 mg/kg, i.p.) were used. Pretreatment with T‐type calcium channel blocker, ethosuximide significantly abolished vincristine‐preconditioning‐induced protective effect. However, pretreatment with L‐type calcium channel blocker, amlodipine did not alter vincristine‐preconditioning‐induced pain‐related behaviors. This indicates that vincristine‐preconditioning has protective effect on pain‐related parameters due to opening of calcium channels, particularly T‐type calcium channels that lead to entry of small magnitude of intracellular calcium through these channels and prevent the deleterious effects of high‐dose vincristine.
Modelling Atlantic mackerel spawning habitat suitability and its future distribution in the north‐west Atlantic
Authors: Mbaye Baye , Doniol‐Valcroze Thomas , Brosset Pablo , Castonguay Martin , Van Beveren Elisabeth , Smith Andrew , Lehoux Caroline , Brickman David , Wang Zeliang , Plourde Stéphane 
Published: November 2019

AbstractWe investigated the effect of environmental conditions on Atlantic mackerel spawning habitat in the southern Gulf of St. Lawrence (sGSL). Based on generalized additive models, we (i) modelled the optimal spawning habitat of mackerel in the sGSL using daily egg production (DEP) in June, (ii) predicted known and new potential present spawning habitats in the GSL and the north‐west Atlantic, and (iii) assessed how they respond to future climate change. Our findings showed that both mackerel presence–absence and given‐presence DEP were associated with sea surface temperature (10–16.5°C), salinity above 31 and depth < 120 m. Adding zooplankton showed a marked effect on the DEP given‐presence compared to the presence–absence. Predictions of spawning habitats under present (1999–2012) and future scenario (2066–2085) conditions were estimated from the presence–absence model without zooplankton, using physical conditions of the BNAM. Under present conditions, our model predicted well the main spawning habitat in the sGSL and other known secondary spawning habitats in the northern GSL (nGSL), the western and southern Newfoundland, and the north‐west Atlantic coast. Under future conditions, our study suggests that spawning habitats in the sGSL and the nGSL would expand. Our results, therefore, suggest that mackerel could benefit from a warmer GSL, minimizing the potential for a northward migration of the stock due to decreasing suitability of the sGSL as its main spawning ground, and a new but spatially limited potential habitat in Newfoundland coasts. These results can be used to inform stock management and develop adaptive management plans in the context of climate change.