bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Effects of Remote-only Communication Among Reference Persons of ICU Patients During COVID-19 Pandemic
Authors: Cattelan Jessy , Castellano Sara , Merdji Hamid , Audusseau Jean , Claude Baptiste , Feuillassier Léa , Cunat Sibylle , Astrie Marc , Aquin Camille , Buis Guillaume , Gehant Edgar , Granier Amandine , Kercha Hassiba , Guillou Camille Le , Martin Guillaume , Roulot Kevin , Meziani Ferhat , Putois Olivier , Helms Julie 
Published: October 2020

Abstract
Background: During COVID-19 pandemic, visitations have been prohibited in most French ICUs. We aimed to assess psychological effects, for reference persons (RPs), of experiencing remote-only communication with both caregivers and the patient during COVID-19 pandemic.Methods: All RPs of patients referred to ICU for COVID-19 were included. HADS, IES-R, and satisfaction were evaluated at admission, discharge/death and 3 months. At 3 months, an interview with a psychologist provided a qualitative description of RPs’ psychological distress.Results: Eighty-eight RPs were interviewed at patient admission and discharge, and 33 accepted the 3rd month-interview. Prevalence of anxiety and depression symptoms was 65% and 32% respectively at patient admission and 27% and 24% at discharge/death, with a significant decrease between ICU admission and discharge/death (23 [16;31] versus 16 [9;21] points, p<0.01). At 3 months, lower HADS decrease was associated with patient death/continued hospitalization, and/or sleeping disorders in RPs (p<0.01). Despite visit prohibition, 99% RPs felt the patient was safe (9 [7;10]/10 points, Likert-type scale). They also felt confident with caregivers, therapeutic decisions (10 [9;10]/10 points) and satisfied with the manner/frequency information was provided (10 [9;10]/10 points). All RPs stressed the specific-type of “responsibility” associated with being an RP in a remote-only context. The 3 salient themes turned out to be dichotomous variables: positive (9 RPs, 27%) vs. negative (24 RPs, 73%) subjective experience; wide (11 RPs, 33%) vs. narrow (22 RPs, 67%) information diffusion strategies: only a third chose to transmit the information to many relatives. Only 10 RPs (30%) related the situation to a prior traumatic experience.Conclusion: In a distressing situation, remote-only communication allowed RPs to remain involved in decision processes and maintain contact with patient and caregivers.Trial registration: NCT04385121. Registered 12 May 2020. https://clinicaltrials.gov/
What is the Relationship Between Helicobacter Pylori CagA Genotypes and Gastrointestinal Diseases in the Iranian Population? A Systematic Review and Meta-Analysis
Authors: Keikha Masoud , Karbalaei Mohsen 
Published: October 2020

Abstract
Background: Helicobacter pylori (H. pylori) is one of the most well-known risk factors for getting the gastric cancer disease. In recent studies, the relationship between its virulence factors, specially CagA (cytotoxin‐associated gene A) toxin and development into the gastrointestinal diseases is taken into consideration. According to review of literature, despite the presence of four motifs A, B, C, and D in CagA toxin, two motifs C and D are more associated with gastrointestinal complications in patients who are infected by H. pylori. Methods: In the present study, we researched about theses ambiguities using a comprehensive meta-analysis study. In this study, we assessed the information of 1762 Iranian patients for potential relationship between all genotypes of cagA gene and gastrointestinal diseases.Results: According to statistical analysis, the abundance of cagA genotypes AB, ABC, ABCC, ABCCC, and ABD in Iranian population is 5.52%, 80.18%, 22.81%, 2.76%, and 0% respectively. In addition, it was determined that there is a significant relationship between cagA genotypes ABCC and ABCCC on the one hand and cagA genotype ABCCC on the other hand with susceptibility to chronic gastritis and gastric cancer respectively.Conclusions: Overall, it can be concluded that the higher number of EPIYA-C copy numbers lead to the higher risk of gastric cancer. According to our results, it seems that the presence of EPIYA-ABCCC motif in strains of H. pylori should be considered as an appropriate marker in preventing the gastric cancer among the Iranian population.
Older Patients’ Perspectives on Factors Contributing to Frequent Visits to the Emergency Department: A Qualitative Interview Study
Authors: Kolk Daisy , Kruiswijk Anton F. , MacNeil-Vroomen Janet L. , Ridderikhof Milan L. , Buurman Bianca M. 
Published: October 2020

Abstract
Background: Older patients are at high risk of unplanned revisits to the emergency department (ED) because of their medical complexity. To reduce the number of ED visits, we need more knowledge about the patient-level, environmental, and healthcare factors involved. The aim of this study was to collect older patients’ perspectives and experiences before and after an ED visit, and to identify factors that possibly contribute to frequent ED revisits.Methods: We performed semi-structured interviews with older patients who frequently visited the ED and were discharged home after an acute visit. Patients were enrolled in the ED of a university medical centre using purposive sampling to achieve maximum variation in heterogeneity. Interviews were recorded, transcribed, and coded independently by two researchers. Theoretical analysis was used to identify recurring patterns and themes in the data. Interviews were conducted until thematic saturation was reached.Results: In-depth interviews were completed with 13 older patients. Three main themes emerged: 1) medical events leading to feelings of crisis, 2) patients’ untreated health problems, and 3) persistent problems in health and daily functioning post discharge. Participants identified problems before and after their ED visit that possibly contributed to further ED visits. These problems included increasing symptoms leading to feelings of crisis, the relationship with the general practitioner, incomplete discharge information at the ED, and inadequate follow-up and lack of recovery after an ED visit.Conclusions: This qualitative study identified multiple factors that may contribute to frequent ED visits among older patients. Older patients in need of acute care might benefit from hospital-at-home interventions, or acute care provided by geriatric emergency teams in the primary care setting. Identifying frailty in the ED is needed to improve discharge communication and adequate follow-up is needed to improve recovery after an acute ED visit.
Large Evaporite Provinces: Geothermal rather than Solar Origin?
Authors: Qin Zhanjie , Tang Chunan , Zhang Xiying , Chen Tiantian , Liu Xiangjun , Li Yongshou , Chen Zhen , Jiang Lianting 
Published: October 2020

Abstract
Large evaporite provinces (LEPs) represent prodigious volumes of evaporites widely developed from the Sinian to Neogene. The reasons why they often quickly develop on a large scale with large areas and thicknesses remain enigmatic. Possible causes range from warming from above to heating from below. The fact that the salt deposits in most salt-bearing basins occur mainly in the Sinian-Cambrian, Permian-Triassic, Jurassic-Cretaceous, and Miocene intervals favours a dominantly tectonic origin rather than a solar driving mechanism. Here, we analysed the spatio-temporal distribution of evaporites based on 138 evaporitic basins and found that throughout the Phanerozoiceon, LEPs occurred across the Earth’s surface in most salt-bearing basins, especially in areas with an evolutionary history of strong tectonic activity. The masses of evaporites, rates of evaporite formation, tectonic movements, and large igneous provinces (LIPs) synergistically developed in the Sinian-Cambrian, Permian, Jurassic-Cretaceous, and Miocene intervals, which are considered to be four of the warmest times since the Sinian. We realize that salt accumulation can proceed without solar energy and can generally be linked to geothermal changes in tectonically active zones. When climatic factors are involved, they may be manifestations of the thermal influence of the crust on the surface.
A scalable workflow for the human exposome
Authors: Hu Xin , Walker Douglas , Liang YongLiang , Smith Matthew , Orr Michael , Juran Brian , Ma Chunyu , Uppal Karan , Martin Greg , Neujahr David , Marsit Carmen , Go Young-Mi , Pennell Kurt , Miller Gary , N. Lazaridis , Jones Dean 
Published: October 2020

Abstract
Complementing the genome with an understanding of the human exposome is an important challenge for contemporary science and technology. Tens of thousands of chemicals are used in commerce, yet cost for targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling to thousands of chemicals, we developed a single-step express liquid extraction (XLE), gas chromatography high-resolution mass spectrometry (GC-HRMS) analysis and computational pipeline to operationalize the human exposome. We show that the workflow supports quantification of environmental chemicals in small human plasma (200 µL) and tissue (≤ 100 mg) samples. The method also provides high resolution, sensitivity and selectivity for exposome epidemiology of mass spectral features without a priori knowledge of chemical identity. The simplicity of the method can facilitate harmonization of environmental biomonitoring between laboratories and enable population level human exposome research with limited sample volume.
Chip on a fiber toward the e-textile computing platform
Authors: Hwang Sunbin , Kang Minji , Lee Aram , Bae Sukang , Lee Seoung-Ki , Lee Sang Hyun , Lee Takhee , Wang Gunuk , Kim Tae-Wook 
Published: October 2020

Abstract
Electronic textiles have been considered one of the desired device platforms due to their dimensional compatibility with fabrics by weaving them with yarn. However, the existing electronic textile platforms are generally composed of only one type of electronic component with a single function on a fiber substrate because of processing challenges. A precise connecting process between each electronic fiber is essential to configure the desired electronic circuits or systems. Here we present a chip on a fiber, a new electronic fiber platform, by introducing large scale integration of electronic device or circuit components onto a one-dimensional microfiber substrate. The electronic components such as transistors, inverters, ring oscillators, and thermocouples were integrated together onto the outer surface of a fiber substrate with precise semiconductor and electrode patterns. Our results show that the electronic components can be integrated on a single fiber with reliable operation. We evaluate the electronic properties of the chip on a fiber as a multifunctional electronic textile platform by testing their switching and data processing, as well as sensing or transducing units for detecting optical/thermal signals. The demonstration of the chip on a fiber suggests significant proof of concepts for realization of high performance with wearable electronic textile systems.
Does Quarantine of Wuhan Effectively Restrict Early Geographic Spread of Novel Coronavirus Epidemic During Chunyun in China? a Spatial Model Study
Authors: Hu Yi , Kong Lingcai , Yao Tong , Chen XinDa , Du Wei 
Published: October 2020

Abstract
BackgroundPrior to Wuhan quarantine in 2020, chunyun, the largest population mobility on this planet, had begun. We quantify impacts of Wuhan quarantine on COVID-19 spread during chunyun at a nationwide and a local level. MethodsDuring the period of January 1 to February 9, 2020, a total of 40,278 confirmed COVID-19 cases from 319 municipalities in mainland China were modelled with the cross-coupled meta-population methods using between-city Baidu migration index. Four scenarios of geographic spread of COVID-19 included the presence of both chunyun and quarantine (baseline); quarantine without chunyun (scenario 1); chunyun without quarantine (scenario 2); and the absence of both chunyun and quarantine (scenario 3). ResultsCompared with the baseline, scenario 1 resulted in 3.84% less cases by February 9 while scenario 2 and 3 resulted in 20.22% and 32.46% more cases by February 9. Investigation of geographic distribution of cases revealed that chunyun facilitated the COVID-19 spread in most but not all cities, and effectiveness of city quarantine was offset by chunyun. Impacts of quarantine of Wuhan during chunyun on the COVID-19 spread demonstrate geographical heterogeneity. ConclusionOur result strongly supports the travel restriction as one of the effective emergency responses and highlight the importance of developing area-specific countermeasures.
Inhibited Long Non-Coding RNA OIP5-AS1 Elevated microRNA-92a to Suppress Proliferation and Metastasis of Ovarian Cancer Cells by Silencing ITGA6
Authors: Wang Yujue , Li Lingling , Zhang Xun , Zhao Xiaolan 
Published: October 2020

Abstract
Objective: Over the years, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been identified as essential biomarkers during the development of malignancies. This study was performed to verify the roles of lncRNA opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) and miR-92a in ovarian cancer (OC).Methods: OIP5-AS1, miR-92a and ITGA6 expression in tissues and cells was assessed. The screened OC cells were respectively with integrin alpha 6 (ITGA6)/OIP5-AS1 silenced vector, miR-92a mimic/inhibitor or their negative controls. The viability, migration, invasion and apoptosis of the cells were determined and the levels of epithelial-mesenchymal transition (EMT)-related proteins were also measured. The interactions between OIP5-AS1 and miR-92a, and between miR-92a and ITGA6 were confirmed by dual luciferase report gene assay and/or RNA pull-down assay.Results: OIP5-AS1 and ITGA6 were upregulated while miR-92a was downregulated in OC tissues versus the adjacent normal tissues. Inhibited OIP5-AS1 or elevated miR-92a repressed EMT, viability, migration and invasion of OC cells, and promoted OC cell apoptosis. These effects that induced by silenced OIP5-AS1 could be reversed by miR-92a inhibitor. The reduction of ITGA6 restricted EMT in OC cells. MiR-92a was a target of OIP5-AS1 and ITGA6 was targeted by miR-92a.Conclusion: OIP5-AS1 silencing promoted miR-92a to repress proliferation and metastasis of OC cells through inhibiting ITGA6. This research may provide potential biomarkers for OC.
Driving Resumption After Critical Illness: A Survey and Thematic Analysis of Patient Experience and Process
Authors: Meyer Joel , Pattison Natalie , Apps Chloe , Gager Melanie , Waldmann Carl 
Published: October 2020

Abstract
Background: Critical care sequelae are common in survivors of critical illness. Physical, psychological and cognitive impairments can affect quality of life for years after the original insult. Driving is an advanced task reliant on complex physical and cognitive functioning. Driving represents a positive recovery milestone. Little is currently known about the driving habits of critical care survivors. The aim of this study was to explore the driving practices of individuals after critical illness. Methods: A purpose-designed questionnaire was distributed to critical care recovery clinic attendees at the 1-year post hospital discharge time point. Results: A response rate of 90% was achieved. All respondents declared their intention to return driving. 68% had resumed driving by 3 months, 77% by 6 months and less than 80% by 1 year. The median interval (range) between critical care discharge and resumption of driving was 8 weeks (1 to 52 weeks). Psychological, physical and cognitive barriers were cited by respondents as barriers to driving resumption. Eight themes around driving resumption were identified through thematic framework content analysis; These were Confidence; Emotional strength/nervousness and anxiety; Concentration; Weakness and fatigue; Physical ability; Intrinsic motivation; Information; Timescales. Conclusion: This study demonstrates that resumption of driving following critical illness is substantially delayed. Qualitative analysis identified potentially modifiable barriers to driving resumption. Keywords: Driving, Critical illness, Critical Care, Recovery, Intensive care
Long-term effects of the mean hemoglobin A1c levels after percutaneous coronary intervention in patients with diabetes
Authors: Bae Jaekyung , Yoon Ji-Hyung , Lee Jung-Hee , Nam Jong-Ho , Lee Chan-Hee , Son Jang-Won , Kim Ung , Park Jong-Seon , Shin Dong-Gu 
Published: October 2020

Abstract
Background: There is controversy regarding the long-term effect of glycemic control on the clinical outcomes after percutaneous coronary intervention (PCI) in diabetes patients with coronary artery disease (CAD). We aimed to evaluate the long-term outcomes of patients with diabetes who underwent PCI, according to the mean hemoglobin A1c (HbA1c) level after PCI.Methods: We retrospectively evaluated 675 diabetes patients with CAD treated with PCI from 2010 to 2013. We categorized the study population into three groups based on the mean observed HbA1c levels during the follow-up duration, as follows: aggressive control (AC) group (HbA1c level <6.5%, n=148), moderate control (MC) group (HbA1c level ≥6.5% and <7.0%, n=138), and uncontrolled (UC) group (HbA1c level ≥7.0%, n=389). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs), defined as cardiac death, myocardial infarction, repeat target vessel revascularization, and stroke. The median follow-up duration was 74.1 (32.6–85.0) months.Results: The mean HbA1c level of the AC group was significantly lower than that of the MC and UC groups (6.04±0.36% vs. 6.74±0.14% vs. 8.39±1.20%, p<0.001). Patients in the AC group were older than those in the MC and UC groups (66.2±10.0 vs. 64.4±11.3 vs. 62.9±10.4 years, p=0.004); however, the other clinical characteristics were similar among the groups. The incidence of MACCEs was significantly lower in the AC group than in the MC and UC groups (16.0% vs. 24.3% vs. 26.3%, p=0.010), mostly driven by the incidence of stroke (4.4% vs. 14.0% vs. 11.0%, p=0.013). Multivariate Cox regression analysis showed that only the AC group was associated with a reduced rate of MACCEs (hazard ratio 0.513, 95% confidence interval 0.326–0.808, p=0.004) compared with the UC group.Conclusion: Our study showed that intensive glycemic control (HbA1c level <6.5%) is associated with improved clinical outcomes after PCI in patients with diabetes.
SARS-CoV 2 (Covid 19) heterogeneous mortality rate across countries may be partly explained by life expectancy, calorie intake and prevalence of diabetes.
Authors: Nkhata Smith G. , Nakoma-Ngoma Theresa , Chilenga Praise M 
Published: October 2020

Abstract
SARS-CoV 2 continues to disproportionately kill people across the world. To understand the reasons for such heterogeneity, we isolated dietary and environmental factors that can either prime or suppress human immunity. We grouped phytochemical and micronutrient rich food (fruits, vegetable and spices) as immunity primers while smoking, alcohol consumption, pollution, high calorie intake and diabetes as immunity suppressing factors and determined correlations with Covid-19 death per million populations (C19DM) using multiple linear regressions or where necessary, best fit trend lines. We also determined correlations between life expectancy alone or in combination with other factors and C19DM. Based on the data, we found no evidence that immunity primers explain C19DM heterogeneity across countries. This observation did not change even after including immunity suppressing factors in the models. Of all the factors under study, life expectancy (years), calorie intake (Kcal/person/day) and prevalence of diabetes (%) had significant association with C19DM (R2 = 0.301, p < 0.000). Therefore, these three factors should be further explored when trying to understand Covid-19 disproportionate mortality across countries.
Fecal and Ruminal Microbiome Components Associated With Methane Emission in Beef Cattle.
Authors: Andrade Bruno G.N. , Afli Haithem , Bressani Flavia A. , Cuadrat Rafael R. C. , Oliveira Priscila S. N. de , Mourão Gerson B. , Coutinho Luiz L. , Reecy James M. , Koltes James E. , Souza Marcela Maria de , Neto Adhemar Zerlotini , Medeiros Sérgio Raposo de , Berndt Alexandre , Palhares Julio C. P. , Regitano Luciana 
Published: October 2020

Abstract
Background: The impact of extreme changes in weather patterns in the economy and humanity welfare are some of the biggest challenges that our civilization is facing. From the anthropogenic activities that contribute to climate change, reducing the impact of farming activities is a priority, since its responsible for up to 18% of greenhouse gases linked to such activities. To this end, we tested if the ruminal and fecal microbiomes components of 52 Brazilian Nelore bulls, belonging to two experimental groups based on the feed intervention, conventional (A) and byproducts based diet (B), could be used as biomarkers for methane (CH4) emission.Results: We identified a total of 5,693 Amplicon Sequence Variants (ASVs) in the Nelore bulls microbiomes from the experimental group B. Statistical analysis showed that the microbiome populations were significantly different among treatment groups. Differential abundance (DA) analysis with the ANCOM approach identified 30 bacterial and 15 archaea ASVs as DA among treatment groups. Random forest models, using either bacteria or archaea ASVs as predictors, were able to predict the treatment group with high accuracy (r2>0.85). Association analysis using Mixed Linear Models indicate that bacterial and archaea ASVs are linked to the CH4 emission phenotype, of which the most prominent were the ruminal ASV 40 and fecal ASV 35. These ASVs contributed to a 9.7% increase and 7.3% decrease of the variation in CH4 emission, respectively, which indicated their potential as targets for feed interventions and/or biomarkers.Conclusion: The feed composition induced significant differences in abundance and richness of ruminal and fecal microbial populations. The dietary treatment based on industrial byproducts applied had an impact on the microbiome diversity of bacteria and archaea, but not on protozoa. Microbiome components (ASVs) of bacteria and archaea can be successfully used to predict the treatment group, thus giving support to the hypothesis that the feed intervention modulate microbiome abundance and diversity. Microbiome components were associated with CH4 emission in both microbiomes. Therefore, both ruminal and fecal ASVs can be used as biomarkers for methane production and emission.