bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen sulfide ameliorates isoflurane-induced cognitive impairment in mice: Implication of caspase-3 activation
Authors: Chen Dan , Fang Yi-Ling , Zhang Ling-Ling , Niu Xiao-Yin , Sun Xiao-Ru , Niu Xiao-Zhen , Zhao Xuan , Li Cheng 
Published: June 2020

Purpose: Isoflurane could induce cognitive impairment and activate caspase-3. However, the mechanism of action is unclear and target interventions are unavailable. The present study examined the potential protective function of hydrogen sulfide (H2S) against isoflurane-induced cognitive impairment.Methods: Effects of NaHS (5 mg/kg) on cognitive impairment induced by isoflurane (1.4% for 2 h) were assessed using a fear-conditioning test in a group of 8-month old mice. H4 human neuroglioma cells, which were transfected with upregulated human amyloid precursor protein were treated for 3 or 6 h with 2% isoflurane, in the presence of 100-μM NaHS in the mice. A group of mice treated with normal saline in place of the NaHS in each case served as control. Western blotting, fluorescence assay, and a mitochondrial swelling assay were employed to observe the results of caspase-3 activation, mitochondrial dysfunction, and ROS and ATP levels.Results: NaHS significantly mitigated isoflurane-induced cognitive impairment in mice. In cultured cells, NaHS reduced caspase-3 activation, ROS, mitochondria membrane reduction, mitochondrial permeability transition pore opening, and cellular ATP level. NaHS could ameliorate cognitiveimpariment induced by isoflurane through inhibiting caspase-3 activation, oxidative stress, and mitochondrial dysfunction.Conclusion: These results indicate that hydrogen sulfide (H2S) has potential protective function against isoflurane-induced cognitive impairment. Further investigation of NaHS as an intervention to attenuate anesthesia-associated neurotoxicity is vital.
Keywords: Hydrogen sulfide, isoflurane-cognition，fear conditioning，neurotoxicity
Autophagy inhibition by chloroquine prevents increase in blood pressure and preserves endothelial functions
Authors: Jain Moon , Iqbal Hina , Yadav Pankaj , Singh Himalaya , Chanda Debabrata , Jagavelu Kumaravelu , Hanif Kashif 
Published: June 2020

Purpose: To determine the effects of lysosomal inhibition of autophagy by chloroquine (CHQ) onhypertension-associated changes in the endothelial functions.
Method: Angiotensin II (Ang II)-treated human endothelial cell line EA.hy926 and renovascularhypertensive rats were subjected to CHQ treatment (in vitro: 0.5, 1, and 2.5 μM; in vivo: 50 mg/kg/dayfor three weeks). Changes in the protein expressions of LC3b II (autophagosome formation marker) andp62 (autophagy flux marker) were assessed using immunoblotting. Cell migration assay, tubuleformation assay (in vitro), and organ bath studies (in vivo) were performed to evaluate the endothelialfunctions. Hemodynamic parameters were measured as well.
Results: A higher expression of LC3b II and a reduced expression of p62 observed in the Ang II-treatedendothelial cells, as well as in the aorta of the hypertensive rats, indicated enhanced autophagy.Treatment with CHQ resulted in reduced autophagy flux (in vitro as well as in vivo) and suppressed AngII-induced endothelial cell migration and angiogenesis (in vitro). The treatment with CHQ was alsoobserved to prevent increase in blood pressure in hypertensive rats and preserved acetylcholineinducedrelaxation in phenylephrine-contracted aorta from the hypertensive rats. In addition, chloroquineattenuated Ang II-induced contractions in the aorta of normotensive as well as hypertensive rats.
Conclusion: These observations indicated that CHQ lowers the blood pressure and preserves thevascular endothelial function during hypertension.
Keywords: Angiotensin II, Autophagy, Chloroquine, Endothelial function, Hypertension, Vasculardysfunction
A sensitive and rapid HPLC-DAD method for the determination of 3-hydroxy-1,2-dimethyl-4-pyridone and its distribution in rats
Authors: Chen Mengdi , Zhang Xuejiao , Li Shuling , Zhang Qiongyao 
Published: June 2020

Purpose: To establish a sensitive and rapid method for the determination of the tissue distribution of 3-hydroxy-1,2-dimethyl-4-pyridone (L1) in vivo, and its plasma protein binding capacity.Methods: This study optimized a reverse-phase HPLC method for specific and sensitive determination of L1 as well as its plasma and tissue distributions. The optimized method was used to determine the plasma protein-binding capacity of L1 in Wistar rats.Results: A rapid, sensitive and simple HPLC-DAD method was established for studying the plasma and tissue distribution of L1. Following TI administration, its liver concentrations peaked at 60 min and 360min, followed 360 min later with peak level in the kidney (second highest). The L1 concentration was significantly lower after 360 min than after 60 min, and values of its mean binding to plasma proteins was 5.2 % at different L1 concentrations.Conclusion: These results indicate that L1 is a drug with rapid-absorption and rapid-elimination thath is distributed widely in vivo in rats. Moreover, the drug has a weak plasma protein-binding capacity.
Keywords: 3-Hydroxy-1,2-dimethyl-4-pyridone, Distribution, Alzheimer’s disease, Therapy
Tanshinone IIA suppresses fibrosis induced by high glucose conditions in HK-2 cells via inhibition of extracellular matrix deposition, reduction of oxidative stress, and inhibition of epithelial to mesenchymal transition
Authors: Zhao Xi , Wang Yao-Guang , Yang Xi-kai , Li Man , Liu Shi-Jie , Zhang Tong-Yan , Wang Yi-Qi 
Published: June 2020

Purpose: To investigate the anti-fibrotic effects of tanshinone IIA (TS) on renal tubular epithelial cells (HK-2 cells) under high glucose conditions and their related molecular mechanism(s) of action.Methods: After treatment with TS (6 μg/mL) for 24 h, the morphology of HK-2 cells stimulated by high glucose was observed under the microscope. Additionally, potential mechanisms related to the antifibrosis effects of TS were evaluated using western blotting assay and quantitative real time PCR (qRTPCR), including transforming growth factor (TGF) β1, α-smooth muscle actin (α-SMA), heme oxygenase 1 (HO-1), laminin (LN), fibronectin (FN), and E-cadherin (E-cad).Results: A high-glucose culture environment induced fibrosis of HK-2 cells, as indicated by changes in cell morphology. The anti-fibrotic effects of TS were mainly associated with a decrease in the expression levels of TGF-β1, α-SMA and LN, while the expression of E-cad increased. These resultsalso revealed that TS increased the expressions of HO-1.Conclusion: The findings suggest that TS suppresses fibrosis caused by high glucose in HK-2 cells by inhibiting extracellular matrix deposition and epithelial-mesenchymal transition and by reducing oxidative stress. Further investigations are needed to evaluate the clinical application of this compound in diabetic nephropathy.
Keywords: Tanshinone IIA, Diabetic nephropathy, HK-2 cells, Fibrosis
ANALISIS KETERAMPILAN MEMANAH BAGI MAHASISWA UIN, SERAMBI DAN UBUDIYAH DI STKIP BINA BANGSA GETSEMPENA BANDA ACEH
Authors: Irfandi  , Zikrur Rahmat  
Published: June 2020

The purpose of this article is to increase strength, speed, accuracy, endurance, and coordination and balance are crucial in producing good and correct archery basic techniques, so as to produce good archery accuracy. In line with that, we think that in order to get the automation and effectiveness of arm muscle strength, arrow speed in order to reach the target in archery, in this case it is necessary to have regular and directed physical training, this is felt to be more effectively done through devotion activities carried out by the student . But in its application the field is actually different, isotonic training, which is a form of exercise with shortened and elongated muscle contractions, in this case the chosen form of exercise is bow pulling training, whereas isometric training is a form of training that contracts with no shortening or elongation, in this case the form of exercise used is to hold the arc pressure (balance). The system of implementing the two forms of training is adjusted to the training program that has been planned and established for the achievement of the peak achievements of UIN, Serambi and Ubudiyah students at the STKIP BBG Banda Aceh. The aim is to improve skills, accuracy, right on target when archery, so in this case the solution offered in this service is to conduct training activities based on daily, weekly and monthly training programs.
Abstrak
Tujuan artikel ini adalah untuk meningkatkan kekuatan, kecepatan, ketepatan, daya tahan, dan koordinasi serta keseimbangan sangat menentukan dalam menghasilkan teknik dasar memanah yang baik dan benar, sehingga menghasilkan ketepatan memanah yang baik. Sejalan dengan itu, kami berpikir bahwa untuk mendapatkan otomatisasi dan efektivitas kekuatan otot lengan, kecepatan anak panah demi mencapai target dalam memanah, maka dalam hal ini perlu latihan fisik secara rutin dan terarah, hal ini dirasa lebih efektif dilakukan melalui kegiatan pengabdian yang dilakukan mahasiswa tersebut. Namun dalam aplikasinya dilapangan justru berbeda, latihan isotonik yaitu suatu bentuk latihan dengan konstraksi otot memendek dan memanjang dalam hal ini bentuk latihan yang dipilih adalah latihan menarik busur, sedangkan latihan isometrik merupakan suatu bentuk latihan yang berkontraksi dengan tidak terjadi pemendekan atau pemanjangan, dalam hal ini bentuk latihan yang dipergunakan adalah menahan tekanan busur (keseimbangan). Sistem pelaksanaan kedua bentuk latihan disesuaikan dengan program latihan yang telah direncanakan dan ditetapkan untuk pencapaian prestasi puncak mahasiswa UIN, Serambi dan Ubudiyah di STKIP BBG Banda Aceh. Tujuannya adalah untuk meningkatkan keterampilan, ketepatan, tepat sasaran saat memanah, maka dalam hal ini solusi yang ditawarkan dalam pengabdian ini adalah dengan melakukan kegiatan pelatihan berpedoman pada program latihan harian, mingguan dan bulanan.
Kata Kunci: Keterampilan, Memanah, Mahasiswa.
Cirugía Robótica Colorectal, en un Hospital de Comunidad Cerrada. Experiencia Inicial
Authors: Lococo Julio , Pedro Luis , Rodríguez Cristian , Vecchio Pablo , Lucena José , Tricarico Juan Martín , Fantozzi Mauricio , Mitidieri Alejandro , Barbalace Nicolás , Dezanzo Vicente 
Published: June 2020

Introducción: La introducción del sistema Da Vinci, ha revolucionado el campo de la cirugía mínima invasiva en el cual el cirujano tiene control de la cámara 3D y los instrumentos son de gran destreza y confort ergonómico, acortando la curva de aprendizaje quirúrgica.Objetivo: Describir nuestra experiencia inicial de cirugía robótica colorectal en un hospital de comunidad cerrada de la Ciudad Autónoma de Buenos Aires.Materiales y Método: Estudio retrospectivo descriptivo sobre una base prospectiva de cirugías colorectales robóticas realizadas por el mismo equipo quirúrgico desde mayo de 2016 a abril de 2019.Resultados: Se operaron 41 pacientes. Trece de ellos fueron colectomías derechas, 17 colectomías izquierdas y 11 cirugías de recto. El tiempo quirúrgico promedio fue de 170 minutos (90-330), la estadía hospitalaria de 4 días (3-30), la tasa de conversión de 7,31% (3/41 pacientes) y la tasa de dehiscencia anastomótica del 9,75% (4/41 pacientes). Morbilidad global del 19.5% (8/41 pacientes).Conclusión: Hemos repasado los resultados iniciales de nuestra experiencia en cirugía robótica colorectal en un número reducido de casos, pero suficiente para evaluar la seguridad y reproducibilidad del método al comienzo de una curva de aprendizaje.
From performance measurement to performance management in the impact investment industry
Authors: van Raak Jeroen , Raaphorst Amber 
Published: June 2020

Impact investments have the potential to play an important role in solving social and environmental problems. Although the sector is growing rapidly, it does face a number of challenges, in particular related to impact measurement. Measuring the impact of such investments, which aim to achieve social and/or environmental impact while simultaneously generating financial returns, has proven difficult.
This study examines the design and application of measurement systems related to impact investments. To investigate this, the seven impact measurement guidelines of the IMWG are used as a framework. We study to which degree impact investors set concrete investment objectives, how they measure and collect data related to the generated impact of the investments, and how they use such data to evaluate investment opportunities. We rely on a qualitative research methodology, including 13 semi-structured interviews among Dutch institutional investors.
We find that impact investors typically set general, but not specific impact objectives. Furthermore, we note that impact investors are still searching for and experimenting with performance measures, and that they would value the development of standardized measures. Such standardized measures may assist in reducing the cost of obtaining investment data, while simultaneously increasing data reliability. Although the obtained impact data is currently hardly used for external reporting and impact data driven investment decisions, the institutional investors expect this to happen in the near future as the process of impact measurement matures. This would enable institutional investors to transition from performance measurement to performance management in the impact investment industry.
The role of built environment practitioners in driving the socio-economic sustainability aspects of sustainable regeneration
Authors: Akotia Julius , Manu Emmanuel , Opoku Alex , Sackey Enoch 
Published: June 2020

In the United Kingdom (UK), over the past three decades efforts have been made to ensure adequate promotion of sustainability objectives through various policy initiatives. However, despite the effort and the existence of these policy initiatives, sustainability projects in particular, regeneration projects are yet to deliver their intended sustainability objectives. While there is a rise in demand for higher sustainability benefits by stakeholders such as clients, communities and policy makers, the delivery of sustainability benefits from sustainability regeneration projects are yet to meet the expectations of these stakeholders. This article provides an overview of sustainability benefits within the context of the sustainable regeneration projects in the UK from a study that examines the roles and sustainability drivers of construction practitioners towards the promotion of sustainability on their regeneration projects. To do so, a qualitative research approach is adopted using a semi-structured interview technique for the study. The data obtained was analysed using content analysis. The findings revealed that out of the eight socio-economic sustainability drivers presented to practitioners, enhancement of reputation was the most important ‘socio-economic’ sustainability driver while the least important driver was legislative and legal requirement. The findings further revealed that majority of practitioners/ organisations were promoting the socio-economic sustainability driver they believed will enable them to meet their own corporate business objectives.
DETERMINANTS OF THE SELECTION OF RAW MATERIALS USED IN ANIMAL FEED PRODUCTION
Authors: Śmiglak-Krajewska Magdalena 
Published: June 2020

The main purpose of this paper was to identify the factors affecting the selection of raw materials used by feed operators in feed production. An attempt was also made to indicate the barriers to increasing the use of native protein plants by feed operators in feed production. Today, many EU countries (including Poland) primarily rely on vegetable protein derived from genetically modified soya bean meal (mainly imported from South America and the U.S.) in addressing their needs for protein raw material used in animal feed. For many years now, Poland has taken steps to increase the production and use of native protein raw material to partially replace soya bean meal imports. The use of mixes of diverse domestic protein sources derived from grain legumes (peas, field beans, lupine) can provide an advantageous alternative to compound feeding stuff based on imported post-extraction soya bean meal. To meet the objective defined above, this paper relied on the results of a 2018 survey conducted with a sample of 29 feed operators located across the country. More than half (55%) of the enterprises surveyed did not use legumes in feed production; the use of legumes was above 10% in only 3% of respondents. When asked about the key factors affecting the selection of raw materials used in production processes, the respondents declared to be interested in buying large batches of homogeneous raw materials that meet specific quality parameters (33% replied “rather yes” and 67% replied “definitely yes”). The protein content of plant seeds used in feed production was identified as another aspect of extreme importance (55% replied “rather yes” and 24% replied “definitely yes”).
Editorial Vol. 10, Nº 4
Authors: Siqueira Sean W. M. , Magdaleno Andréa Magalhães 
Published: June 2020

A iSys – Revista Brasileira de Sistemas de Informação é uma publicação científica da Comissão Especial de Sistemas de Informação (CESI) da Sociedade Brasileira de Computação (SBC), em parceria com o Programa de Pós-Graduação em Informática (PPGI) da Universidade Federal do Estado do Rio de Janeiro (UNIRIO). A revista é distribuída em formato eletrônico através do Sistema Eletrônico de Editoração de Revistas (http://www.seer.unirio.br/index.php/isys/index).
Edição especial sobre 10 anos de Sistemas de Informação na iSys – de número 4 do Volume 10 (2017) com 5 (cinco) artigos, todos submetidos para edição especial a revista. Editores Convidados: Sean Wolfgand Matsui Siqueira e Andréa Magalhães Magdaleno Editores-chefes: Rodrigo Pereira Santos e André Pimenta Freire
Editorial Vol. 12, No 3
Authors: Santos Rodrigo , Moura Raimundo Santos , Freire André 
Published: June 2020

A iSys – Revista Brasileira de Sistemas de Informação é uma publicação científica da Comissão Especial de Sistemas de Informação (CESI) da Sociedade Brasileira de Computação (SBC), em parceria com o Programa de Pós-Graduação em Informática (PPGI) da Universidade Federal do Estado do Rio de Janeiro (UNIRIO).
Nesta presente edição – de número 3 do Volume 12 (2019) – são publicadas versões estendidas de 7 artigos apresentados no VII Brazilian Workshop on Social Network Analysis and Mining (BraSNAM 2018).
Dívida Técnica de Usabilidade em Projetos de Software: Um Estudo de Casos Múltiplos
Authors: Lage Luiz Carlos Da Fonseca , Trevisan Daniela G. , Kalinowski Marcos 
Published: June 2020

Contexto: Ao longo dos anos, vários estudos foram conduzidos com o objetivo de compreender o fenômeno da Dívida Técnica (DT) e suas implica- ções no desenvolvimento de software. A maioria desses estudos se concentram em tipos de DT relacionados à código-fonte. A ausência de estudos empíricos sobre a dívida de usabilidade motivou nossa pesquisa. Objetivo: O objetivo deste artigo é fornecer uma caracterização inicial da dívida técnica de usabi- lidade em projetos de software com relação à sua ocorrência, tipo e esforço de resolução. Método: Realizamos um estudo de casos múltiplos, analisando itens de DT de cinco projetos de software de quatro empresas publicas Brasileiras. Resultados: Após várias etapas de seleção, classificação e validação, identi- ficamos 145 itens de DT nos sistemas de gerenciamento de mudanças, usados nos projetos. A análise desses itens permitiu observar que 13,8% dos itens do DT se referiam à dívida de usabilidade (variando de 10,4% a 20,8% nos cinco projetos). Os itens de dívida de usabilidade identificados cobrem uma série de problemas de usabilidade relevantes, violando oito das dez heurísticas de usabilidade de Nielsen. Em relação ao esforço para pagar a DT, medido em horas-homem, estimado pelos gerentes de projeto, os itens de dívida de usabi- lidade apresentaram um baixo esforço, variando de 5,1% a 6,7% do total do esforço estimado nos projetos analisados. Conclusão: Considerando que os itens de DT de usabilidade são frequentes, dizem respeito a questões relevantes de usabilidade e requerem pouco esforço para seu pagamento, propomos que ações para identificar e pagar este tipo de DT devam receber alta prioridade nas estratégias de gestão de DT.
A Evasão no Curso de Sistemas de Informação sob uma perspectiva tridimensional de fatores
Authors: Saraiva Juliana , Rodrigues Amanda , Dantas Vanessa 
Published: June 2020

Os altos índices de evasão na graduação vêm demandando pesquisas para entender este fenômeno, inclusive em cursos como Sistema de Informação. Assim, este trabalho investigou a evasão sob a perspectiva de fatores acadêmicos, humanos e sociais na UFPB. Um survey foi respondido por 53 evadidos e uma análise quantitativa sobre dados gerados pelo Sistema de Controle Acadêmico da instituição - 243 registros - foi realizada, indicando a falta de políticas públicas e universitárias referente a auxílios financeiros como uma das maiores causas de evasão. Os resultados sugerem que não há diferença no deficit de aprendizagem e nas taxas de cancelamento de matrícula de alunos de diferentes gêneros e origem escolar (pública ou privada), demonstrando que decisões institucionais devem ser tomadas levando em conta uma visão tridimensional sobre os fatores de evasão.
Dermoscopy Training Effect on Diagnostic Accuracy of Skin Lesions in Canadian Family Medicine Physicians Using the Triage Amalgamated Dermoscopic Algorithm
Authors: Sawyers Elizabeth A. , Wigle Donald T. , Marghoob Ashfaq A. , Blum Andreas 
Published: June 2020

Background: Accurate identification of cutaneous lesions is an essential skill for family medicine physicians (FMPs). Studies show significant improvement in skin cancer detection with dermoscopy use. Frontline FMPs are an ideal target group for dermoscopy training. The 3-step Triage Amalgamated Dermoscopic Algorithm (TADA) facilitates high sensitivity and specificity for pigmented and nonpigmented skin lesions. Step I requires unequivocal identification of dermoscopic features for 1 of 3 benign skin lesions: angioma, dermatofibroma, or seborrheic keratosis. If absent, steps II and III are applied assessing for features of architectural disorder and malignancies with organized, symmetric patterns, respectively.
Objective: To assess FMPs’ diagnostic accuracy of benign and malignant skin lesions before and after training in TADA step I.
Methods: In this repeated-measures observational study, 33 dermoscopy-naive FMPs attending an introductory dermoscopy workshop each assessed gross and corresponding dermoscopic photographic images of 50 pigmented and nonpigmented skin lesions (23 benign, 27 malignant) for features of TADA step I lesions before and after training. Analyses compared diagnostic accuracy in relation to training and baseline physician characteristics.
Results: Diagnostic accuracy improved from 76.4% to 90.8% (P < 0.001) and from 85.0% to 90.0% (P = 0.01), respectively, for all lesions and for all TADA I lesions. Female sex was significant as a predictor of individual posttraining performance (all lesions combined, P = 0.02).
Conclusions: Results show significant improvement in diagnostic accuracies for benign and malignant skin lesions with introductory dermoscopy training using TADA step I. This will reduce unnecessary benign lesion excision and enhance referral sensitivity, conserving specialist resources.