bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tricuspid regurgitant jet velocity and myocardial tissue Doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups ‐ revisiting this controversial concept after 16 years of additional evidence
Authors: Shah Payal , Suriany Silvie , Kato Roberta , Bush Adam M. , Chalacheva Patjanaporn , Veluswamy Saranya , Denton Christopher C. , Russell Kelly , Khaleel Maha , Forman Henry J. , Khoo Michael C. K. , Sposto Richard , Coates Thomas D. , Wood John C. , Detterich Jon 
Published: September 2020

AbstractSickle cell disease (SCD) is a monogenic hemoglobinopathy associated with significant morbidity and mortality. Cardiopulmonary, vascular and sudden death are the reasons for the majority of young adult mortality in SCD. To better understand the clinical importance of multi‐level vascular dysfunction, in 2009 we assessed cardiac function including tricuspid regurgitant jet velocity (TRV), tissue velocity in systole(S′) and diastole (E′), inflammatory, rheologic and hemolytic biomarkers as predictors of mortality in patients with SCD. With up to 9 years of follow up, we determined survival in 95 children, adolescents and adults with SCD. Thirty‐eight patients (40%) were less than 21 years old at initial evaluation. Survival and Cox proportional‐hazards analysis were performed. There was 19% mortality in our cohort, with median age at death of 35 years. In the pediatric subset, there was 11% mortality during the follow up period. The causes of death included cardiovascular and pulmonary complications in addition to other end‐organ failure. On Cox proportional‐hazards analysis, our model predicts that a 0.1 m/s increase in TRV increases risk of mortality 3%, 1 cm/s increase in S′ results in a 91% increase, and 1 cm/s decrease in E′ results in a 43% increase in mortality. While excluding cardiac parameters, higher plasma free hemoglobin was significantly associated with risk of mortality (p=.049). In conclusion, elevated TRV and altered markers of cardiac systolic and diastolic function predict mortality in a cohort of adolescents and young adult patients with SCD. These predictors should be considered when counseling cardiovascular risk and therapeutic optimization at transition to adult providers.
Study on preparation and process of poly(MMA‐St) thermally expandablecore‐shellmicrospheres
Authors: Tian Sheng‐cai , Cao Jian‐xin , Xie Gui‐ming , Wang Ming‐wei , Shi Yong‐yong , Yi Yun , Yang Chun‐liang , Xiao Yi‐han , Wei Xian‐liang , Tian Bei‐ming , Ma Zi‐han 
Published: September 2020

AbstractThermally expandable microspheres were synthesized by the suspension polymerization of methyl methacrylate (MMA) and styrene (St) in the presence of paraffin blowing agents. The effect of the monomer composition, the initiator, the blowing agent, the polymerization temperature on the morphology and structure of microspheres were studied. The results showed that AIBN initiated the water phase polymerization of MMA to form secondary polymer particles adsorbed on the surface of the microspheres. MMA diffused from the oil phase to the water phase, which accelerated the phase separation and facilitated the formation of core‐shell microspheres. However, LPO could not initiate the water phase polymerization, the phase separation was slow and there was an intermediate state with a porous surface. When the boiling point of the blowing agent was lower than the polymerization temperature, the microspheres were porous and there were a large number of holes on the surface.
Evaluation of the engineered polysaccharide alpha‐1,3 glucan in a thermoplastic polyurethane model system
Authors: Mok Jorge Wu , Behabtu Natnael , Lenges Christian , Sendijarevic Ibrahim , Sendijarevic Aisa 
Published: September 2020

AbstractEnzymatic polymerization is under development as novel scalable process technology to convert sucrose to engineered polysaccharides. Similar to established monomer‐based polymerization processes, this approach allows for the synthesis of glucose‐based polymers with controlled polymer linkage, structure, and material morphology. Using enzymatic polymerization, alpha‐1,3‐polyglucose (glucan) can now be produced from sugar on scales required for industrial applications. This alpha‐1,3 glucan material, with accessible primary and secondary hydroxyl groups within the overall defined particle morphology, is especially of interest as a partially reactive component in polyurethane chemistry. This study explores the impact of alpha‐1,3‐glucan as additive in a thermoplastic polyurethane model system and the improvement in mechanical properties of these composites. Glucan was effectively first mixed with a polyether polyol diol, forming a stable dispersion with narrow particle size distribution, followed by reaction with diisocyanate and chain extender to form the polyurethane matrix. The analysis of the generated polyurethane matrix indicates that the hydroxyl groups of the dispersed glucan particles directly react with isocyanate. Tetrahydrofuran solubility of the formed polyurethane compound decreased with the addition of glucan, providing evidence of covalent bonding of glucan leading to cross‐linking of the polyurethane matrix. Thermal analysis of this model system suggests that the glucan additive induces hard segment crystallization, resulting in increased hardness and tensile modulus compared with the reference. Based on the observed property enhancements, engineered polysaccharides provide a sustainable performance additive for polyurethane materials.
The impact of publication on freshwater pearl mussel conservation: To conceal or to reveal the location of threatened habitats?
Authors: Popov Igor 
Published: September 2020

Abstract

The freshwater pearl mussel, Margaritifera margaritifera, is a threatened species. One of the threats faced by this species is direct extermination by poachers, and therefore some researchers conceal information on the locations of pearl mussel habitats. For example, some researchers do not publish the names of the rivers where pearl mussels occur, whereas other researchers do.

Concealing the names of rivers containing pearl mussels makes them unknown not only to potential offenders but also to administrators, nature conservation practitioners, and ordinary citizens. As a result, no protection measures are undertaken, which is all the more regrettable as damage to pearl mussel habitats can occur accidentally.

Concealing details of the location of pearl mussel habitats in publications has an adverse impact on the work of specialists, as they do not have access to enough information to study and analyse the biology and distribution of these molluscs.

One river with pearl mussels in the Gulf of Finland was initially described anonymously (as ‘River B’). Unfortunately, the river was subject to severe human impact, and the largest aggregation of pearl mussels was almost exterminated in the process of constructing a new electric supply line.

Concealing information on pearl mussel habitats in the Russian section of the Baltic Sea basin was also shown to have been a poor decision. Although the threat from potential poachers was insignificant because of the low commercial value of pearl mussels, the authorities remained uninformed about the existence of valuable habitats.

The question of whether the locations of pearl mussel habitats should be concealed or revealed in scientific publications does not have an unambiguous answer and should be considered on a case‐to‐case basis; however, the cases for which disclosure is reasonable seem to be more numerous.
A population model provides support for management decisions, enables ongoing research and reinforces strong partnerships to manage a threatened freshwater crayfish
Authors: Whiterod Nick S. , Todd Charles R. , Zukowski Sylvia , Raymond Scott M.C. , Asmus Martin , Todd Macgregor J. 
Published: September 2020

Abstract

Many freshwater crayfish are threatened with extinction owing to varied threats such as urban development, pollution, over‐harvest, and climate change, as well as invasive species.
A recently published manuscript in Aquatic Conservation: Marine and Freshwater Ecosystems described a stochastic, age‐based population model for the large freshwater crayfish Murray crayfish, Euastacus armatus, which is now threatened across much of its range in the Murray–Darling Basin in south‐eastern Australia.
The model was constructed for three regional populations using the best available knowledge of life‐history traits such as longevity, size at onset of sexual maturity, fecundity, and survival, along with an account of density dependence. The model provides a framework to explore aspects of the conservation and management of the species, including assessing the influence of recreational harvest and environmental disturbance such as hypoxic blackwater, which affected the species significantly in 2010–2011.
The application of the model provided retrospective justification for regulation amendments and highlighted biologically realistic timeframes for the recovery of impaired populations. This knowledge has assisted multi‐jurisdictional fisheries management agencies to undertake routine reviews of fishery regulations, as well as to inform stakeholders of the benefits of the regulation amendments.
Refinement of the modelling framework has already provided additional insight and it is anticipated that future application will help to address other important management questions. The modelling outcomes are at present informing conservation assessment of the species under the Australian Government's Environmental Protection and Biodiversity Conservation Act 1999.
The benefit of the population model can be summarized as: providing a framework to inform and justify management decisions; enabling additional research; and guiding conservation assessment. This has strengthened strong partnerships (between ecologists, managers, and recreational fishers) required to manage the species effectively.
Environmental flow releases trigger spawning of a threatened fish: Research insights and publication enhance management, credibility and relationships
Authors: Amtstaetter Frank , Suter Stephanie 
Published: September 2020

Abstract

Publication is an important stage in the research process, but determining the impact of published research on environmental outcomes is a complex challenge that is seldom undertaken. In 2016, a published study used acoustic telemetry techniques and drift sampling to demonstrate that environmental flow releases triggered downstream spawning migrations by a threatened fish species, the Australian grayling (Prototroctes maraena). The study provided support for the use of these types of releases to mitigate some of the effects of river regulation on fishes.
The impacts of this research and its publication in Aquatic Conservation: Marine and Freshwater Ecosystems were thoroughly reviewed to identify benefits to water managers, researchers, institutes, and the wider community.
Five areas in which this research, and its publication, had a recognizable impact are enhanced confidence for water managers in undertaking actions; greater acceptance in the wider community of environmental flow releases; enhanced relationships among water managers; the credibility arising from the work being published in a peer‐reviewed journal; and setting a foundation for further evidence‐based management.
The ecology of the endemic quillwort Isoëtes malinverniana: From basic research to legal and in situ conservation
Authors: Abeli Thomas , Caldeira Cecilio F. , Barni Elena , Siniscalco Consolata , Parco Valentina , Rossi Graziano 
Published: September 2020

Abstract

Scientific publications on the conservation of threatened species can drive practical conservation solutions for endangered species. Yet, a posteriori assessment of the impact of such publications is rarely seen in the scientific literature.
The impact of two articles published in Aquatic Conservation: Marine and Freshwater Ecosystems (AQC) on the conservation of the endangered quillwort Isoëtes malinverniana is assessed. The articles were the result of a 10‐year study on the focal species that eventually led to the first reintroduction of I. malinverniana. The first article described the development of a cost‐effective model for the selection of suitable reintroduction sites for the species. The second article provided a summary of the techniques used to reintroduce the species and included techniques of ex situ propagation, recipient site preparation, planting methods, and monitoring.
This article reviews the practical conservation actions for I. malinverniana that followed the publication of two AQC papers and how they may affect research and conservation for other quillworts and aquatic macrophytes.
The results were surprising and went well beyond the initial expectations of the authors. Both AQC publications stimulated the conservation of I. malinverniana from different points of view. They contributed by informing scientists and policymakers of the risk of extinction of this species, leading to the establishment of a new protected area in Piedmont (northern Italy).
Our published data represent a sound starting point for funding opportunities in the context of the European Union LIFE programme. Further impacts include an expansion of knowledge on oligotrophic habitat management, the assessment of conservation status, and the education of the general public, with the last of these greatly enhanced by the two ex situ collections created in the botanic gardens of Tourin and Pavia. Interestingly, other authors are now using our approach in research and conservation on other endemic and endangered quillworts worldwide.
Conservation of fish communities: Extending the ‘research life cycle’ by achieving practical effects
Authors: Bylak Aneta , Kukuła Krzysztof 
Published: September 2020

Abstract

This article highlights the practical impact of our 2018 Aquatic Conservation: Marine and Freshwater Ecosystems publication, ‘Importance of peripheral basins: Implications for the conservation of fish assemblages’, which described fish communities in a Polish river.
Data on the fish assemblages of the Dniester River (Black Sea basin) are scarce; however, evidence indicates that the assemblages have declined. In our 2018 study, we hypothesized that the peripheral basin (the small basin on the edge) of the larger Upper Dniester River basin (the Strwiąż River) could maintain good ecological status and contained unique fish assemblages.
To examine the influence of historical factors and assess the role of peripheral basins on fish conservation, data from the Strwiąż basin were compared with the adjacent but unconnected Wiar basin (the Vistula basin; Baltic Sea basin). The Strwiąż River fish assemblages featured higher species richness and a greater number of native Ponto–Caspian species that function near the edge of their ranges.
This article focuses on four impacts of the 2018 publication: increasing awareness by various groups and organizations of the unique character of the surveyed river basin; highlighting important issues in assessing the ecological status of European rivers; driving the red‐listing of species and the development of stream fish conservation strategies; and identifying possible future impacts.
Our 2018 publication demonstrated the value of studying peripheral basins, which may affect conservation strategy development and encourage study of the importance of other peripheral basins and their role in aquatic resources conservation. Our article influenced the interpretation of fish‐based biotic indices and the conduct of monitoring work and its evaluation. It also strongly emphasized the native origin of the racer goby (Babka gymnotrachelus) in the Strwiąż River, which was important for subsequent works seeking to change the legal status of the species in Poland.
The potential for expanding sustainable biogas production and some possible impacts in specific countries
Authors: Dale Bruce E. , Bozzetto Stefano , Couturier Christian , Fabbri Claudio , Hilbert Jorge A. , Ong Rebecca , Richard Tom , Rossi Lorella , Thelen Kurt D. , Woods Jeremy 
Published: September 2020

AbstractCurrent food production practices tend to damage and deplete soil, diminish biodiversity, and degrade water supplies. For agriculture to become environmentally sustainable and simultaneously increase food output for a growing world population, fundamental changes in agricultural production systems are required. Renewable energy can reduce greenhouse gases (GHGs) but we also need simple, low‐cost approaches to remove atmospheric carbon and sequester it in stable forms. Recycling of digestate from the anaerobic digestion of agricultural and waste materials to soils can sequester atmospheric carbon and provide many other economic, social and environmental benefits. Biogasdoneright™ (BDR) is a set of practices that link biogas production with sustainable agriculture. The BDR approach to sustainable agriculture is being implemented on a large scale in Italy. In this paper, we examine the potential impact of implementing BDR in selected other countries. The biomethane potential in these countries, estimated conservatively, varies from about 10–30% of their current annual natural gas consumption. Biomethane from sequential (double) crops provides by far the greatest fraction of the biomethane potential. Double cropping also drives many of the environmental and economic benefits of BDR systems. Depending on where and how widely it is implemented, the production of biogas in BDR systems could have very significant national‐level impacts. For example, sufficient biomethane could be produced in Argentina to completely eliminate imports of natural gas, equivalent to about 28% of Argentina's 2017 trade deficit. In the USA, renewable biogas could generate electricity equal to nearly all of the electricity currently produced by domestic solar and wind resources. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd
Radiation therapy and secondary malignancy in Li‐Fraumeni syndrome: A hereditary cancer registry study
Authors: Hendrickson Peter G. , Luo Yukun , Kohlmann Wendy , Schiffman Josh , Maese Luke , Bishop Andrew J. , Lloyd Shane , Kokeny Kristine E. , Hitchcock Ying J. , Poppe Matthew M. , Gaffney David K. , Tao Randa 
Published: September 2020

AbstractBackgroundLi‐Fraumeni Syndrome (LFS) is a rare cancer‐predisposing condition caused by germline mutations in TP53. Conventional wisdom and prior work has implied an increased risk of secondary malignancy in LFS patients treated with radiation therapy (RT); however, this risk is not well‐characterized. Here we describe the risk of subsequent malignancy and cancer‐related death in LFS patients after undergoing RT for a first or second primary cancer.MethodsWe reviewed a multi‐institutional hereditary cancer registry of patients with germline TP53 mutations who were treated from 2004 to 2017. We assessed the rate of subsequent malignancy and death in the patients who received RT (RT group) as part of their cancer treatment compared to those who did not (non‐RT group).ResultsForty patients with LFS were identified and 14 received RT with curative intent as part of their cancer treatment. The median time to follow‐up after RT was 4.5 years. Fifty percent (7/14) of patients in the curative‐intent group developed a subsequent malignancy (median time 3.5 years) compared to 46% of patients in the non‐RT group (median time 5.0 years). Four of seven subsequent malignancies occurred within a prior radiation field and all shared histology with the primary cancer suggesting recurrence rather than new malignancy.ConclusionWe found that four of14 patients treated with RT developed in‐field malignancies. All had the same histology as the primary suggesting local recurrences rather than RT‐induced malignancies. We recommend that RT should be considered as part of the treatment algorithm when clinically indicated and after multidisciplinary discussion.
Pure erythroid leukemia
Authors: Chen Jason C. , Lee Winston Y. , Schaefer Jordan K. , Bixby Dale L. 
Published: September 2020

AbstractThe diagnosis of pure erythroid leukemia (PEL) can be challenging. Prompt identification of CD45+, CD34‐, CD71+, CD117+, and E‐cadherin+ erythroblasts is important. The differential diagnosis is broad and includes megaloblastic anemia.
Treatment of scleromyxedema with lenalidomide, bortezomib and dexamethasone: A case report and review of the literature
Authors: Win Hninyee , Gowin Krisstina 
Published: September 2020

AbstractScleromyxedema is a rare and progressive disease that currently has no standard treatment. Triplet therapy with lenalidomide, bortezomib, and dexamethasone can be an effective therapy for scleromyxedema, especially in patients with refractory or relapsed disease.
A novel KRT1 c.1433A>G p.(Glu478Gly) mutation in a newborn with epidermolytic ichthyosis
Authors: Caroppo Francesca , Cama Elena , Salmaso Roberto , Bertolin Cinzia , Salviati Leonardo , Belloni Fortina Anna 
Published: September 2020

AbstractEpidermolytic Ichthyosis is a rare genodermatosis related to point mutations affecting the genes encoding for keratin 1 or keratin 10. We report a case of Epidermolytic Ichthyosis in a newborn with a novel mutation (c.1433A>G) of KRT1 gene.
Adherence and out‐of‐pocket costs among Medicare beneficiaries who are prescribed oral targeted therapies for advanced prostate cancer
Authors: Caram Megan E. V. , Oerline Mary K. , Dusetzina Stacie , Herrel Lindsey A. , Modi Parth K. , Kaufman Samuel R. , Skolarus Ted A. , Hollenbeck Brent K. , Shahinian Vahakn 
Published: September 2020

BackgroundAbiraterone and enzalutamide are high‐cost oral therapies that increasingly are used to treat patients with advanced prostate cancer; these agents carry the potential for significant financial consequences to patients. In the current study, the authors investigated coping and material measures of the financial hardship of these therapies among patients with Medicare Part D coverage.MethodsThe authors performed a retrospective cohort study on a 20% sample of Medicare Part D enrollees who underwent treatment with abiraterone or enzalutamide between July 2013 and June 2015. The authors described the variability in adherence rates and out‐of‐pocket payments among hospital referral regions in the first 6 months of therapy and determined whether adherence and out‐of‐pocket payments were associated with patient factors and the socioeconomic characteristics of where a patient was treated.ResultsThere were 4153 patients who filled abiraterone or enzalutamide prescriptions through Medicare Part D in 228 hospital referral regions. The mean adherence rate was 75%. The median monthly out‐of‐pocket payment for abiraterone and enzalutamide was $706 (range, $0‐$3505). After multilevel, multivariable adjustment for patient and regional factors, adherence was found to be lower in patients who were older (69% for patients aged ≥85 years vs 76% for patients aged <70 years; P < .01) and in those with low‐income subsidies (69% in those with a subsidy vs 76% in those without a subsidy; P < .01). Both Hispanic ethnicity and living in a hospital referral region with a higher percentage of Hispanic beneficiaries were found to be independently associated with higher out‐of‐pocket payments for abiraterone and enzalutamide.ConclusionsThere were substantial variations in the adherence rate and out‐of‐pocket payments among Medicare Part D beneficiaries who were prescribed abiraterone and enzalutamide. Sociodemographic patient and regional factors were found to be associated with both adherence and out‐of‐pocket payments.