bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal Diagnosis of FATCO Syndrome (Fibular Aplasia, Tibial
Campomelia, and Oligosyndactyly) with 2D/3D Ultrasonography
Authors: Izadi Meisam , Salehnia Nasim 
Published: October 2020

IntroductionFibular hemimelia is a congenital lower limb anomaly characterized by the partial or
complete absence of the fibula. It includes a spectrum ranging from mild fibular
hypoplasia to complete fibular aplasia. Although rare in occurrence, it is the most
common congenital absence of long bone of the extremities 1.
Einfluss erhöhter Lipoprotein-konzentrationen auf die Prognose von Patienten mit Diabetes mellitus
Authors: Julius Ulrich 
Published: October 2020

ZUSAMMENFASSUNGIn dieser Übersicht wird der gegenwärtige Kenntnisstand zu Erhöhungen der Lipoproteinkonzentrationen bei Menschen mit Diabetes im Hinblick auf die Prognose in 3 Kategorien dargestellt: Entwicklung von kardiovaskulären Ereignissen, akute Pankreatitis, Neuauftreten eines Diabetes. Triglyzeridanstiege sind sehr wahrscheinlich atherogen. Exzessiv erhöhte Triglyzeridspiegel werden im Rahmen eines Chylomikronämie-Syndroms beobachtet, das akute Pankreatitiden induzieren kann. Im Fokus steht bei Diabetespatienten LDL-Cholesterin, das auch bei einer leichten Anhebung das Risiko für Arteriosklerose erhöht, zumal die LDL-Partikel chemisch modifiziert sein können. Hier stehen als Therapieoptionen Statine, aber auch Ezetimib und PCSK9-Inhibitoren und als ultima ratio eine Lipoproteinapherese zur Verfügung. Die jüngsten internationalen Richtlinien der ESC/EAS haben die LDL-Cholesterin-Zielwerte deutlich herabgesetzt. Es wird die Relevanz der Parameter Non-HDL-Cholesterin und Apolipoprotein B diskutiert. Eine zunehmend größere Bedeutung als Risikofaktor hat der Lipoprotein(a)-Spiegel. Triglyzeriderhöhungen sind mit dem Neuauftreten eines Diabetes verknüpft, während dies bei hohen Lipoprotein(a)-Spiegeln eher nicht der Fall ist.
Homöopathisierte Misteltherapie beim CUP-Syndrom
Authors: Wilkens Johannes 
Published: October 2020

ZusammenfassungCUP-Syndrome sind schwierig in der Therapie und in der Regel nur palliativ behandelbar. Die Gabe von potenzierten Misteln kann die Lebensqualität und auch die Lebensquantität häufig wesentlich verbessern. Der Autor stellt drei Kasuistiken vor.
Das Studienprotokoll „UPGRADE – Kreative Stärkungsgruppen als innovative Versorgungsform für hochbelastete Mitarbeiter/innen im Gesundheitswesen
Authors: Pieper Claudia , Schröer Sarah , Spanier Helen , Cohen Simon , Russ Holger , Baer Udo 
Published: October 2020

ZusammenfassungMitarbeiterinnen und Mitarbeiter im Gesundheitswesen sind berufsbedingt besonderen Belastungen ausgesetzt. Diese entstehen durch das Auseinandersetzten mit Leid und Tod oder durch traumatisierende Erfahrungen mit Patientinnen und Patienten. Daraus können negative gesundheitliche Auswirkungen seelischer und körperlicher Art folgen. Möchten Betroffene dem entgegenwirken, so lassen sich nur selten präventive Maßnahmen finden. Gefördert durch den Innovationsfonds sollen Mitarbeiterinnen und Mitarbeiter im Gesundheitswesen innovativ in Form von Kreativen Stärkungsgruppen nachhaltig gestärkt werden.Das UPGRADE-Projekt bietet die Teilnahme an Kreativen Stärkungsgruppen. Zur Untersuchung der Wirksamkeit wird eine randomisierte kontrollierte Studie mit 366 Teilnehmerinnen und Teilnehmern (Alter > 18) durchgeführt. Die Interventionsgruppe nimmt an den Kreativen Stärkungsgruppen teil. Beide Gruppen werden zu 3 Zeitpunkten zur Arbeitszufriedenheit, der subjektiven Arbeitsbelastung und Arbeitsfähigkeit befragt, um eine mögliche Veränderung durch die Teilnahme an den Kreativen Stärkungsgruppen festzustellen. Um die Umsetzbarkeit der Intervention zu bewerten, wird eine ergänzende formative Evaluation durchgeführt.Wenn sich das Angebot der Kreativen Stärkungsgruppen im UPGRADE-Projekt als niedrigschwelliges Angebot für Mitarbeiterinnen und Mitarbeiter im Gesundheitswesen als wirksam erweist, ist eine Anpassung und Umsetzung in anderen Bereichen möglich und wichtig.
How Reliable are Commercially Available Glypican4 ELISA
Kits?
Authors: Buhl Joseph P. , Garten Antje , Kratzsch Jürgen , Kiess Wieland , Penke Melanie 
Published: October 2020

Abstract
Objective Glypican4 is an interesting new adipokine, which
seems to play an important role in developmental processes and is
potentially associated with metabolic changes in obesity and type 2 diabetes
mellitus. Currently, only a few studies examined glypican4 in human blood,
mainly in adults.
Design, Patients and Measurements The aim of our study was to
investigate glypican4 serum levels in lean, overweight, and obese children
and adolescents, to unravel a possible association between glypican4 serum
levels and parameters of obesity and insulin resistance. In order to
determine a suitable method for investigating glypican4 serum levels, we
validated two commercially available human glypican4 ELISA kits, using serum
and plasma samples of an obese, insulin-resistant patient, and a healthy
control subject, a human recombinant glypican4 protein fragment and
glypican4-overexpressing cell lysate.
Results Using ELISA kit #1 we were not able to detect values
above background level, apart from standard curve values. ELISA kit #2
initially seemed suitable to measure glypican4, but further validation
experiments showed non-linearity of serial dilutions, no recognition of a
human recombinant glypican4 protein fragment and non-linearity in the
recovery of glypican4-overexpressing cell lysate. In addition, there was a
considerable decrease (approx. 68%) of measured values between two
experiments, performed at different time points with aliquots of the same
serum sample. Contrary to that, further experiments found sample stability
not to be compromised.
Conclusions Extensive evaluation of the performance of two
commercially available ELISA kits led to the conclusion that none of them is
applicable for the measurement of glypican4 in human blood samples.
Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE
Strategy
Authors: Vanelle Patrice , Ibrahimi Maroua , Khoumeri Omar , Abderrahim Raoudha , Terme Thierry 
Published: October 2020

AbstractA one-pot synthesis of new 3-benzylphthalide derivatives was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with methyl 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3H)-one products in moderate to good yields.
Neurogenic Bladder: Epidemiology, Diagnosis, and Management
Authors: Panicker Jalesh N. 
Published: October 2020

AbstractLower urinary tract dysfunction is a common sequel of neurological disease resulting in symptoms that significantly impacts quality of life. The site of the neurological lesion and its nature influence the pattern of dysfunction. The risk for developing upper urinary tract damage and renal failure is considerably lower in patients with slowly progressive nontraumatic neurological disorders, compared with those with spinal cord injury or spina bifida. This acknowledged difference in morbidity is considered when developing appropriate management algorithms. The preliminary evaluation consists of history taking, and a bladder diary and may be supplemented by tests such as uroflowmetry, post-void residual measurement, renal ultrasound, (video-)urodynamics, neurophysiology, and urethrocystoscopy, depending on the clinical indications. Incomplete bladder emptying is most often managed by intermittent catheterization, and storage dysfunction is managed by antimuscarinic medications. Intra-detrusor injections of onabotulinumtoxinA have revolutionized the management of neurogenic detrusor overactivity. Neuromodulation offers promise for managing both storage and voiding dysfunction. In select patients, reconstructive urological surgery may become necessary. An individualized, patient-tailored approach is required for the management of lower urinary tract dysfunction in this special population.
Effect of Long-Term Repeated Interval Rehabilitation on the Gross Motor Function Measure in Children with Cerebral Palsy
Authors: Stark Christina , Duran Ibrahim , Martakis Kyriakos , Spiess Karoline , Semler Oliver , Schoenau Eckhard 
Published: October 2020

Abstract
Background The efficacy of interventions for cerebral palsy (CP) has been frequently investigated with inconclusive results and motor function measured by the Gross Motor Function Measure (GMFM-66) is common.
Objective In this observational analysis, we quantify the GMFM-66 change scores of the second and third year of a multimodal rehabilitation program (interval rehabilitation including home-based, vibration-assisted training) in children with CP.
Methods The study was a retrospective analysis of children with CP (2–13 years) participating for a second (n = 262) and third year (n = 86) in the rehabilitation program with GMFM-66 scores at start (M0), after 4 months (M4) of intensive training, and after 8 months of follow-up (M12). A method was previously developed to differentiate between possible treatment effects and expected development under standard of care for GMFM-66 scores using Cohen's d effect size (ES; size of difference).
Results After the treatment phase of 4 months (M4) in the second year, 125 of 262 children were responder (ES ≥ 0.2) and 137 children nonresponder (ES < 0.2); mean ES for nonresponder was −0.212 (trivial) and for responder 0.836 (large). After M4 in the third year, 43 children of 86 were responder (ES = 0.881 [large]) and 43 nonresponder (ES = −0.124 [trivial]).
Discussion and Conclusion Repeated rehabilitation shows a large additional treatment effect to standard of care in 50% of children which is likely due to the intervention, because in the follow-up period (standard of care), no additional treatment effect was observed and the children followed their expected development.
International Patent Survey of Products and Processes Concerning Homeopathy
Authors: Freitas Ana Carolina Lemos , Belchior Gisele Da Silva , Nemitz Marina Cardoso 
Published: October 2020

Abstract
Background Homeopathy is a complementary medicine characterized by the use of diluted and potentized medicines. Innovations in this area are constantly being proposed in the relevant literature, such as scientific articles and patents. The objective of this study was to carry out a patent survey of homeopathic products and processes.
Methods A free and international patent database, Espacenet, was used. The search was carried out using the keyword homeop*, with two approaches: (1) no date restrictions for the search and (2) a date limit for the publication years 2008 to 2018. The patents from the limited period were organized as depositor countries, ownerships and groups, including homeopathic formulations, equipment, packaging, production procedures, and analytical methods.
Results Without date restriction, 601 patents were identified in the survey. Of these, 174 were related to homeopathy and published in the period 2008 to 2018. Technologies come mainly from the following countries: United States (55 patents), Russia (24), Germany (15), France (13), India (12), Ukraine (11), Brazil (6), and China (6). Among the ownerships, 69% of patent applications were by independent depositors, 23% by companies, 7.5% by universities, and 0.5% by company/university partnerships. New formulations represented 75.9% of technologies, whilst the others comprised 14.3% for equipment, 3.8% for drugs packaging, 3.8% for production procedures, and 2.2% for analytical methods.
Conclusions The present review helps visualize the homeopathy-related patents published in recent years, as well as the main countries and researchers investing in the field of homeopathy.
Restricted Wrist Rotation after an Ulnar Head Fracture: A Report of Two Cases
Authors: Kato Tomoyuki , Abe Koji , Sato Kazuki , Nakamura Toshiyasu 
Published: October 2020

Abstract
Background Isolated ulnar head fracture is a rare entity, and the restriction of range of motion in the wrist is rarely reported.
Case Description We report two cases of conservatively treated ulnar head malunion with restricted supination and pronation. The increased tension of the volar portion of the triangular fibrocartilage complex was observed, and the surgical treatment significantly improved the range of motion.
Literature Review There are a few reports on isolated ulnar head fracture. Other causes of restricted supination and pronation of the wrist are mostly due to the interposition of soft tissues or loose bodies.
Clinical Relevance Malunion after ulnar head fracture can cause restriction of wrist supination and pronation. Surgical intervention may be considered if restricted range of motion remains after conservative treatment.
Tick-Borne-Associated Illnesses in the Pediatric Intensive Care Unit
Authors: Lessner Kaila , Krawiec Conrad 
Published: October 2020

AbstractWhen unrecognized and antibiotic delay occurs, Lyme disease, Rocky Mountain–spotted fever, babesiosis, and human ehrlichiosis and anaplasmosis can result in multiorgan system dysfunction and potentially death. This review focuses on the early recognition, evaluation, and stabilization of the rare life-threatening sequelae seen in tick-borne illnesses that require admission in the pediatric intensive care unit.
The Knowledge of Sleep Medicine among Dental Interns in Northern Jordan
Authors: Alkhader Mustafa , Saadeh Rami 
Published: October 2020

AbstractObjectives  The diagnosis and treatment of patients with sleep disorders are the most challenging issues in dentistry. The aim of this study was to assess the knowledge among dental interns in Northern Jordan about sleep medicine and sleep disorders.Materials and Methods This cross-sectional study was performed using the Assessment of Sleep Knowledge in Medical Education (ASKME) questionnaire. The questionnaire was given to 88 dental interns (52 females and 36 males) in Northern Jordan. Chi-squared test was utilized for data analysis.Results The mean score of the ASKME questionnaire was 12 out of 30 (40%). The majority of dental interns (88.6%) correctly answered ≤ 50% of the questions. No association was found between gender and score results.Conclusions Dental interns in Northern Jordan have a low level of knowledge about sleep medicine and sleep disorders. Dental faculties should provide courses related to sleep medicine throughout undergraduate education.
Gangliocytic Paraganglioma of the Filum Terminale. A Rare Entity
Authors: Tavares Sofia Isabel Carneiro Pereira Guerra , Costa Gonçalo Maria Sengo Agante Guerreiro 
Published: October 2020

AbstractParagangliomas are rare, benign and slow-growing neuroendocrine tumors that can arise from the adrenal medulla (85–90%) or from the extra-adrenal paraganglia.In the central nervous system (CNS), they can be found at several sites, but more often at the cauda equina and filum terminale region, where they account for between 2.5 and 3.8% of total tumor cases of that region. There are only 8 cases described in the literature that mention the presence of the gangliocytic variant of this entity at the filum terminale.We present the case of a 41-year-old man with chronic lumbar pain refractory to medical treatment, without any associated neurological deficits. Magnetic resonance imaging (MRI) revealed an intradural, extramedullar oval lesion with regular contours and homogeneous caption of contrast at L1 level.He was submitted to surgical treatment, with complete resection of the lesion. The histological analysis revealed a gangliocytic paraganglioma of the filum terminale. At 5 years of follow-up, he remains asymptomatic and without any signs of relapse.These are lesions with an overall good prognosis with gross total resection. Although the recurrence rate is extremely low, prolonged observation is recommended due to the slow-growing nature of the tumor, being estimated that between 1 and 4% can recur even after gross total removal.
Pterygopalatine Fossa: Microsurgical Anatomy and its Relevance for Skull Base Surgery
Authors: Isolan Gustavo Rassier , Bernardi Julio Mocellin , Telles João Paulo Mota , Rabelo Nícollas Nunes , Figueiredo Eberval Gadelha 
Published: October 2020

Abstract
Introduction The purpose of this study was to define the anatomical relationships of the pterygopalatine fossa (PPF) and its operative implications in skull base surgical approaches.
Methods Ten cadaveric heads were dissected at the Dianne and M Gazi Yasargil Educational Center MicrosurgicaLaboratory, in Little Rock, AK, USA. The PPF was exposed through an extended dissection with mandible and pterygoid plate removal.
Results The PPF has the shape of an inverted cone. Its boundaries are the pterygomaxillary fissure; the maxilla, anteriorly; the medial plate of the pterygoid process, and greater wing of the sphenoid process, posteriorly; the palatine bone, medially; and the body of the sphenoid process, superiorly. Its contents are the maxillary division of the trigeminal nerve and its branches; the pterygopalatine ganglion; the pterygopalatine portion of the maxillary artery (MA) and its branches; and the venous network. Differential diagnosis of PPF masses includes perineural tumoral extension along the maxillary nerve, schwannomas, neurofibromas, angiofibromas, hemangiomas, and ectopic salivary gland tissue. Transmaxillary and transpalatal approaches require extensive resection of bony structures and are narrow in the deeper part of the approach, impairing the surgical vision and maneuverability. Endoscopic surgery solves this problem, bringing the light source to the center of the surgical field, allowing proper visualization of the surgical field, extreme close-ups, and different view angles.
Conclusion We provide detailed information on the fossa's boundaries, intercommunications with adjacent structures, anatomy of the maxillary artery, and its variations. It is discussed in the context of clinical affections and surgical approaches of this specific region, including pterygomaxillary disjunction and skull base tumors.
Insulin Dosing, Glycemic Control, and Perinatal Outcomes in Pregnancies Complicated by Type-2 Diabetes
Authors: Nadeau Hugh C.G. , Maxted Marta E. , Madhavan Devika , Pierce Stephanie L. , Feghali Maisa , Scifres Christina 
Published: October 2020

Objective This study aimed to evaluate the prevalence of severe insulin resistance (insulin requirements ≥2 units/kg) at delivery and the relationship between severe insulin resistance, glycemic control, and adverse perinatal outcomes in pregnant women with type-2 diabetes mellitus.Study Design This is a retrospective cohort study of women with type-2 diabetes mellitus who delivered between January 2015 and December 2017 at a tertiary academic medical center. Maternal demographic information, self-monitored blood sugars, and insulin doses were abstracted from the medical record. Multivariable logistic regression was used to identify maternal baseline characteristics associated with severe insulin resistance at delivery.Results Overall 72/160 (45%) of women had severe insulin resistance. Women in the severe insulin resistance group demonstrated evidence of suboptimal glycemic control as evidenced by higher mean hemoglobin A1c (HbA1c) values (7.2 [ ±  1.1] vs. 6.6 [ ±  1.3%], p = 0.003), higher mean fasting (104.0 [ ±  17.4] vs. 95.2 [ ±  11.7 mg/dL], p < 0.001) and postprandial glucose values (132.4 [ ±  17.2] vs. 121.9 [ ± 16.9 mg/dL]), p < 0.001), and a higher percentage of total glucose values that were elevated above targets (37.7 [95% confidence interval (CI): 26.8–50] vs. 25.6 [95% CI: 13.3–41.3%], p < 0.001). Maternal HbA1c ≥6.5% and insulin use prior to pregnancy were associated with a higher prevalence of severe insulin resistance, while Hispanic ethnicity and non-White race were associated with a lower prevalence of severe insulin resistance. The rates of adverse perinatal outcomes including large for gestational age (LGA) birth weight, cesarean delivery, and hypertensive disorders of pregnancy did not differ between groups.Conclusion Severe insulin resistance is common among pregnant women with type-2 diabetes, and it is associated with suboptimal glycemic control. Future studies are necessary to develop strategies to identify women with severe insulin resistance early in pregnancy and facilitate adequate insulin dosing.Key Points
No Traces of SARS-CoV-2 In Wounds of COVID-19 Positive Patients: A Pilot Study
Authors: Gaba Sunil , Kampalli Gowtham , Goyal Kapil , Suri Vikas , Chauhan Poonam , Meena Shyam C. , Bhatnagar Ankur , Singh Mini P. , Sharma Ramesh K. 
Published: October 2020

Abstract
Background This study was performed to investigate the presence of SARS-CoV-2 virus in wounds of COVID-19 positive patients.
Methods This is a single-center observational study. COVID-19 patients with wounds (traumatic/infective/surgical) were included in this study. Preoperative, intraoperative, or postoperative specimens were collected and analyzed with real-time reverse transcriptase polymerase chain reaction (rRT-PCR) to know the presence of the virus.
Results A total of eight patients were included in this study. Eleven samples were collected (seven wound swabs, two peritoneal fluids, and two tissue specimens) and analyzed. None of the samples from the wound tested positive for the virus while they were tested positive for nasal swab taken simultaneously or within 3 days prior.
Conclusion The wounds of COVID-19 patients are considered negative and can be managed with routine wound precautions.
The effect of electrical muscle stimulation on quadriceps muscle strength and activation patterns in healthy young adults
Authors: Nishikawa Yuichi , Watanabe Kohei , Takahashi Tetsuya , Maeda Noriaki , Maruyama Hirofumi , Kimura Hiroaki 
Published: October 2020

AbstractThe aim of the present study was to clarify the effect of electrical muscle stimulation (EMS) on the spatial distribution pattern of electromyographic activity in healthy young adults using multi‐channel surface electromyography (SEMG). A total of 32 men (age = 21–26 years) were randomly assigned to the intervention group (n = 18) and control group (n = 14). Participants in the intervention group performed EMS to stimulate the bilateral lower limb muscle for four weeks (20 min/3 days/week). The control group received no EMS intervention. To understand the effects of EMS, the following measurements were made at baseline and four weeks: knee extension torque, muscle mass, and spatial distribution of neuromuscular activation during a target torques [10%, 30%, 50%, and 70% of the maximal voluntary contraction (MVC)] using multi‐channel SEMG. The knee extension torque was significantly increased in intervention group compared with control group (p < 0.0001). However, the muscle mass did not show a significant difference between pre and post intervention in each group. The muscle activation patterns of 50% and 70% MVC task showed significant enhancement between baseline and four weeks in the intervention group. Furthermore, a moderate correlation between Δ knee extension torque and Δ spatial distribution pattern of electromyographic activity of 50% and 70% MVC in the intervention group was observed. These results suggested EMS intervention induced different distribution of muscle activity at high‐intensity muscle contraction compared with low‐intensity muscle contraction.