bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimization of greenhouse gas emissions from extended aeration activated sludge process
Authors: Yapıcıoğlu Pelin 
Published: November 2020

AbstractOne of the greenhouse gas (GHG) emission resources is industrial wastewater treatment plants. In this study, on-site and off-site greenhouse gas emissions of an extended aeration activated sludge process in a meat processing wastewater treatment plant were estimated using a new developed approach based on the IPCC method. On-site emissions were regarded as the emissions related to the biochemical treatment process and microbial activity in the wastewater. On-site emissions were estimated from organic materials removal from wastewater and microbial mass activity. Biological oxygen demand (BOD) and chemical oxygen demand (COD) removal were considered as pollutant resources of carbon dioxide (CO2) and methane (CH4), respectively. Off-site emission was estimated from electricity consumption, chemical use and the sludge stabilization process. This paper aimed to determine and reduce on-site and off-site emissions for the extended aeration process in an industrial wastewater treatment plant. Modification of operating conditions was applied to reduce GHG emissions. The results revealed that electricity consumption was the major source of the greenhouse gas emissions for this process with a value of 6,002.77 kg CO2e/d. The minimization of total GHG emissions reached up to 17.1% by modifying the treatment process conditions.
In-silico Analysis of Angiotensin-converting Enzyme 2 (ACE2) of Livestock, Pet and Poultry Animals to Determine its Susceptibility to SARS–CoV-2 Infection
Authors: Kumar Aman , Panwar Anil , Batra Kanisht , De Sachinandan , Maan Sushila 
Published: November 2020

Background:
Novel coronavirus SARS-CoV-2 is responsible for the COVID-19
pandemic. It was first reported in Wuhan, China, in December 2019, and despite the tremendous
efforts to control the disease, it has now spread almost all over the world. The interaction of SARSCoV-
2spike protein and its acceptor protein ACE2 is an important issue in determining viral host
range and cross-species infection, while the binding capacity of spike protein to ACE2 of different
species is unknown.

Objective:
The present study has been conducted to determine the susceptibility of livestock, poultry and pets to SARSCoV-2.

Methods:
We evaluated the receptor-utilizing capability of ACE2s from various species by
sequence alignment, phylogenetic clustering and protein-ligand interaction studies with the
currently known ACE2s utilized by SARS-CoV-2.

Result:
In-silico study predicted that SARS-CoV-2 tends to utilize ACE2s of various animal
species with varied possible interactions. The probability of the receptor utilization will be greater
in horse and poor in chicken, followed by ruminants.

Conclusion:
Present study predicted that SARS-CoV-2 tends to utilize ACE2s of various livestock
and poultry species with greater probability in equine and poor in chicken. The study may provide
important insights into the animal models for SARS-CoV-2 and animal management for COVID-
19 control.
Identification of an MiRNA-mRNA Regulatory Network in Colorectal Cancer
Authors: Cui Ming-fu , Wu Yuan-yu , Chen Ming-yan , Zhao Yang , Han Song-yun , Wang Rui-jie , Zhang Haiyan , Fang Xue-dong 
Published: November 2020

Background:
Colorectal cancer (CRC) is the fourth most prevalent cancer in the world.
However, the molecular mechanism underlying CRC is largely unknown.

Objective:
To explore the pathogenic mechanism of CRC and to facilitate better diagnosis and
treatment of this disease.

Methods:
Differentially expressed miRNAs (DEMs) and genes (DEGs) in CRC vs. Control
samples from the miRNA expression data in GSE115513 and the miRNA and mRNA expression
data in the TCGA-COAD dataset were screened, followed by the construction of the miRNAmRNA
regulatory network. Functional and pathway enrichment analysis, protein-protein
interaction (PPI) analysis, and survival analysis were then performed for these DEGs and DEMs.

Results:
We identified 64 DEMs from the GSE115513 dataset and 265 DEMs and 2218 DEGs
from the TCGA-COAD dataset. miR-27a-3p was a hub DEM with the highest degree in the
miRNA-mRNA network, while GRIN2B and PCDH10 were hub DEGs targeted by multiple
miRNAs, including miR-27a-3p. SNAP25 and GRIN2B were also hub DEGs with the highest
degree of interactions in the PPI network. These DEMs and DEGs were significantly enriched in
multiple KEGG pathways, including proteoglycans expression and cAMP signaling pathway in
cancer. Finally, seven DEGs, including FJX1 Dsc2, and hsa-miR-375, were revealed to be
correlated with CRC prognosis.

Conclusions:
Aberrant expressions of genes and miRNAs were involved in the pathogenesis of
CRC, probably by regulating proteoglycans expression and cAMP signaling. miR-27a-3p,
PCDH10, GRIN2B, FJX1, Dsc2, and hsa-miR-375 were identified as potential targets for
understanding the pathogenic mechanism of CRC. In addition, FJX1, Dsc2 and hsa-miR-375 were
identified as potential predictive markers for CRC prognosis.
Withdrawal Notice: Synergistic Effect of Myricetin and Phenolic Acid Derivatives on the Reversal of Dengue Fever Related Thrombocytopenia and its Pharmacokinetics study in Plasma by using HPLC and UPLC-Q-TOF
Authors: Anjum Varisha , Ali Faraat , Joshi Sweta , Anjum Areefa , Ali Asad 
Published: November 2020

As per the request of the authors and editor of the journal Current Drug Metabolism, the article has been withdrawn due to issues related to authorship.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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A Comprehensive Review on Microbubble Concept, Development and Its Application in Therapeutic Drug Delivery and Clinical Management of Disease
Authors: Rathor Sandeep , Aamir Sheikh , Bhatt Dinesh C. , Kumar Krishan , Kumar Vikash 
Published: November 2020

Background:
The general purpose of this review was to briefly describe the Gastro-Retentive
Drug Delivery System (GRDDS) and to primarily focus on mechanisms of flotation for gastric retention.

Methods:
The principle mechanism of Floating Drug Delivery Systems (FDDS) is mainly based on
hydro-dynamically controlled low-density system, which gets swollen when comes in contact with the
gastric environment and remains buoyant for an extended period of time with improved bioavailability
and therapeutic efficacy. The main perspective of this review was to focus on microbubble drug delivery
due to its wide range of applications.

Results:
Microbubble is a new, economically viable, and non-invasive technique that is alternative to
conventional techniques. The size of microbubbles ranges from 1-100 micrometers, which contain oxygen
or air and remain suspended for prolonged drug release. Due to its great potential, microbubble is
used in the therapeutic delivery of drug molecules or genetic material at their specific targeted site in
various diseases. The recent research also suggests that ultrasound-mediated microbubble is more frequently
used in the biomedical field for imaging of site-specific molecule targeting for the detection of
disease and site-specific drug delivery.

Conclusion:
Gastro-retentive floating drug delivery system was considered as the most favorable approach
for site-specific drug delivery. But nowadays, microbubble is gaining more popularity for its
potential applications in the biomedical field. In recent years, there is much progress in microbubble
for site-specific delivery of a drug or genetic material. Recent research also suggests that the ultrasound-
mediated microbubble has shown a positive impact on the diagnosis and clinical management of
various diseases such as liver cirrhosis, brain tumor, ocular, and urinary tract infection.
Immunoinformatic Approach for the Identification of Potential Epitopes Against Stenotrophomonas maltophilia: A Global Opportunistic Pathogen
Authors: Basker Pragathi Ravilla , Sugumar Shobana 
Published: November 2020

Background:
Stenotrophomonas maltophilia is an aerobic, non-fermentative, gram negative,
multidrug resistant and opportunistic nosocomial pathogen. It is associated with high morbidity
and mortality in severely immunocompromised paediatric patients, including neonates. Immunoinformatic
analysis paved a new way to design epitope-based vaccines which resulted in a potential
immunogen with advantages such as lower cost, specific immunity, ease of production, devoid
of side effects, and less time consumption than conventional vaccines. Till date, there is no development
in the vaccines or antibody-based treatments for S. maltophilia-associated infections.

Introduction:
Currently, epitope-based peptide vaccines against pathogenic bacteria have grasped
more attention. In our present study, we have utilized various immunoinformatic tools to find a
prominent epitope that interacts with the maximum number of HLA alleles and also with the maximum
population coverage for developing a vaccine against Stenotrophomonas maltophilia.

Methods:
This study has incorporated an immunoinformatic based screening approach to explore
potential epitope-based vaccine candidates in Stenotrophomonas maltophilia proteome. In this
study, 4365 proteins of the Stenotrophomonas maltophilia K279a proteome were screened to identify
potential antigens that could be used as a good candidate for the vaccine. Various immunoinformatic
tools were used to predict the binding of the promiscuous epitopes with Major Histocompatibility
Complex (MHC) class I molecules. Other properties such as allergenicity, physiochemical
properties, adhesion properties, antigenicity, population coverage, epitope conservancy
and toxicity were analysed for the predicted epitope.

Results:
This study helps in finding the prominent epitope in Stenotrophomonas infections. Hence,
the main objective in this research was to screen complete Stenotrophomonas maltophilia proteome
to recognize putative epitope candidates for vaccine design. Using computational vaccinology and
immunoinformatic tools approach, several aspects are obligatory to be fulfilled by an epitope to be
considered as a vaccine candidate. Our findings were promising and showed that the predicted epitopes
were non-allergenic and fulfilled other parameters required for being a suitable candidate
based on certain physio-chemical, antigenic and adhesion properties.

Conclusion:
The epitopes LLFVLCWPL and KSGEGKCGA have shown the highest binding score
of −103 and −78.1 kcal/mol with HLA-A*0201 and HLA-B*0702 MHC class I allele, respectively.
They were also predicted to be immunogenic and non-allergenic. Further various immunological tests,
both in vivo and in vitro methods, should be performed for finding the efficiency of the predicted
epitope in the development of a targeted vaccine against Stenotrophomonas maltophilia infection.
Detection, Treatment Planning, and Genetic Predisposition of Bruxism: A Systematic Mapping Process and Network Visualization Technique
Authors: Heyat Md Belal Bin , Akhtar Faijan , Khan Masood Hasan , Ullah Najeeb , Gul Ijaz , Khan Haroon , Lai Dakun 
Published: November 2020

Background:
Lack of sleep generates many disorders and bruxism is one of them. It has
affected almost 31% of the world population.

Aim:
The purpose of this paper is to determine the volume of the research conducted on bruxism
and to create a database. We aimed to highlight critical issues for further research commitments
and communications. This paper designs a comprehensive and very perception-based picture of
bruxism disorder.

Methods:
The research-based work uses three methods, including a systematic mapping process,
network visualization, and literature review. Softwares, such as VOSviewer, MATLAB, and MEGA-
X, have been utilized to analyze the work. We have researched deep insights of information to
retrieve the present understanding of bruxism disorder from dental to psychological concepts, from
engineering detection to clinical treatment, and from temporomandibular disorder to biological
genes.

Results:
We found 10 keywords and 77 items of bruxism in PubMed, Scopus, Google Scholar, and
Web of Science databases based on previous publications. These keywords and items are helpful
for all types of researchers, which include engineering, science, and medical background personals.
11 genes and 75 research articles with approximately 115,077 subjects, for the analysis of detection,
treatment, child and adolescent bruxism, have been reviewed in the research work.

Conclusion:
It has been found that bruxism altogether has sleep, neurological, dental, and genetic
disorder components and is a complex phenomenon. This study has also mentioned the future direction
and gap in research conducted so far on bruxism and has also tried to provide goals for the upcoming
research to be accomplished in a more significant and scientific manner.
Nano-Lipid-Carriers for the Treatment of Vitiligo: A Recent Update, Pathophysiology and Mechanism of Drug Delivery
Authors: Das Supratim , Kaur Sukhbir 
Published: November 2020

Background::
Vitiligo is an auto-immune disease with white-coloured disfiguring patches
or spots on the skin surface. It is highly prevalent in several corners of the world. This disease
spreads in different age groups.

Aim::
The main aim of this review is to provide overview of Pathophysiology and Lipid-based nano-carriers for the treatment of vitiligo.

Methods::
The conventional delivery systems available have limited efficacy due to less retention
of the drug in the epidermal layer where melanocytes reside. In order to overcome these issues, an
advanced delivery system with lipid-based nano-carriers for the treatment of vitiligo was proven to
be better as per the literature explored.

Results::
This review summarizes the pathophysiology along with novel Lipid-based nano-carriers for the treatment of vitiligo are described well.

Conclusion::
Though various treatment regimens are present for the disease, nano-lipid carrier systems
are significantly gaining importance nowadays, due to their high effectivity in topically acting
on the target site. Nano-lipid carrier systems such as liposomes, ethosomes, transethosomes and
transferosomes can be said to be at the top of the list in acting effectively against vitiligo or several
other tropical diseases.
The Study of the Dependence of Optimal Structure of Composite Materials Containing Hollow Aluminosilicate Microspheres on Humidity
Authors: Atyaksheva Aleksandra , Sarsikeyev Yermek , Atyaksheva Anastasia , Galtseva Olga , Rogachev Aleksander 
Published: November 2020

Background:
Experimental data on the conditions for the formation of gravel materials containing
hollow aluminosilicate microspheres with a possibility to receive optimum structure and properties
depending on humidity with the use of various binders are presented in this article. This article focuses
on the scientific study of the possibility to optimize the physical and mechanical properties of
composite materials.

Objective:
The main goal of this research is an exploration of energy-efficient building materials to be
used to replace natural materials with industrial wastes and development of the theory and practice of
how to obtain light and ultra-light gravel materials based on mineral binders and waste dump ash and
slag mixtures of hydraulic removal. The objective of this research is to study the composite material
containing hollow aluminosilicate microspheres.

Method:
The study is based on the application of the separation method for power and heat engineering
functions. The method is based on the use of the structure optimality factor that takes the primary
and secondary stress fields of the structural gravel material into account. It shows the possibility to obtain
gravel material with the most uniform distribution of nano - and microparticles in the gravel material
and to form stable matrices with minimization of stress concentrations. Experiments show that the
thickness of the cement shell that performs power functions is directly related to the size of the raw
granules. At the same time, the cement crust thickness regardless of the binder type has a higher formation
rate for larger diameter granules when the moisture content increases.

Results:
The conditions of formation for gravel composite materials containing hollow aluminosilicate
microspheres were studied. The optimal structure and properties of the gravel composite material were
obtained. The dependence of the strength function on humidity and the binder type was investigated.
The optimal size and shape of gravel material containing aluminosilicate hollow microspheres with a
minimum thickness of a cement shell and a maximum strength function were obtained.

Conclusion.:
The obtained structure enables us to separate power and heat engineering functions in the
material and to minimize the content of the aggressive environment centers.
The Influence of Profitability on Firm Value with Capital Structure as The Mediator
Authors: Mubyarto Novi 
Published: November 2020

Abstract: The purpose of this research was to determine the direct and indirect effect of profitability on firm value using capital structure as a mediator. This involves using panel data from 44 companies listed on LQ45 as of 31st December 2015-2018 and analyzed using the path analysis method including Sobel Test and Bootstrapping technique. The results showed a positive and significant direct effect of profitability on firm value while the indirect effect using capital structure as a mediator between the two variables was found to be negative and significant. Moreover, the direct influence of capital structure on firm value was discovered to be negative and significant while the introduction of profitability variables in the relationship led to a positive and significant influence. Similarly, the direct effect of profitability on firm value using capital structure as the controlling variable was also found to be positive and significant.Keywords: firm value, capital structure, profitabilityPengaruh Profitabilitas Terhadap Nilai Perusahaan dengan Struktur Modal Sebagai MediatorAbstrak: Tujuan dari penelitian ini adalah untuk mengkaji bagaimana pengaruh langsung profitabilitas terhadap nilai perusahaan, dan pengaruh tidak langsung melalui struktur modal sebagai mediator. Menggunakan data panel dari 44 perusahaan yang tercatat di LQ45 per tanggal 31 Desember selama periode 2015 sampai 2018. Metode analisis yang digunakan adalah metode analisis jalur (Path Analysis), dengan Teknik Sobel Test dan Bootsrapping. Hasil riset membuktikan bahwa terdapat pengaruh langsung yang positif dan signifikan antara profitabilitas terhadap nilai perusahaan. Namun, jika dilihat secara tidak langsung pengaruh profitabilitas terhadap nilai perusahaan melalui struktur modal sebagai mediator adalah negatif dan signifikan. Selanjutnya, pengaruh langsung profitabilitas terhadap struktur modal adalah negatif dan signifikan. Sementara ketika dikontrol oleh variabel profitabilitas, pengaruh struktur modal terhadap nilai perusahaan positif dan signifikan. Begitu pula dengan pengaruh langsung profitabilitas terhadap nilai perusahaan dengan mengontrol variabel struktur modal juga positif dan signifikan.Kata kunci: nilai perusahaan, struktur modal, profitabilitas
Product Quality and After-Sales Service in Improving Customer Satisfaction and Loyalty
Authors: Purwati Astri Ayu , Fitrio Tomy , Ben Frank , Hamzah Muhammad Luthfi 
Published: November 2020

Abstract: In this globalization era, companies are always required to show excellent performance and be able to adapt in changes and current business competitiveness. The aim of this research was to analyzed the effect of product quality and after-sales service on customer satisfaction and loyalty in one of distributor companies in Pekanbaru Riau namely PT Oscarmas Pekanbaru. The sampling technique used in this study was probability sampling with the total of 82 customers as respondents. Data analysis technique was Structural Equation Model (SEM) using Smart PLS. The results of this research showed that the product quality had no significant effect on customer satisfaction but had significant effect on customer loyalty, after-sales services had significant effect on both customer satisfaction and customer loyalty and satisfaction had no effect on customer loyalty. Thus, study proved that between product quality and after-sales service had no indirect effect on customer loyalty through satisfaction.Keywords: product quality, after-sales service, customer satisfaction, customer loyalty Kualitas Produk dan Layanan Purna Jual dalam Meningkatkan Kepuasan dan Loyalitas PelangganAbstrak: Di era globalisasi ini, perusahaan selalu dituntut untuk menunjukkan kinerja yang sangat baik dan mampu beradaptasi dalam perubahan dan daya saing bisnis saat ini. Tujuan dari penelitian ini adalah untuk menganalisis dampak kualitas produk dan layanan purna jual terhadap kepuasan dan loyalitas pelanggan di salah satu perusahaan distributor di Pekanbaru Riau yaitu PT Oscarmas Pekanbaru. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah probability sampling dengan total 82 pelanggan sebagai responden. Teknik analisis data adalah Structural Equation Model (SEM) menggunakan Smart PLS. Hasil penelitian ini menunjukkan bahwa kualitas produk tidak memiliki pengaruh signifikan terhadap kepuasan pelanggan tetapi memiliki pengaruh signifikan terhadap loyalitas pelanggan, setelah layanan penjualan memiliki pengaruh signifikan terhadap kepuasan pelanggan dan loyalitas pelanggan dan kepuasan tidak berpengaruh pada loyalitas pelanggan. Dengan demikian penelitian membuktikan bahwa antara kualitas produk dan layanan purna jual tidak memiliki efek tidak langsung pada loyalitas pelanggan melalui kepuasan.Kata kunci: kualitas produk, layanan purna jual, kepuasan pelanggan, loyalitas pelanggan
Is Democracy Really The Best Medicine?
Authors: Lins Rodrigo , Rebouças Ian , Domingos Amanda 
Published: November 2020

Pandemics are nothing new to the human race. From the Plague of Justinian to the current Covid-19, the world has seen all sorts of contagious disease. But do different political regimes react differently? We argue that the political regime has no major influence. More specifically: democratic and autocratic regimes have similar performances in taking action to combat the disease. The reasoning for this, however, vary. We do believe that the volatility is higher within the authoritarian group. To test this hypotheses, we will conduct a survival analysis, having the adoption of a strict social isolation policy as the event of interest. We will control for institutional variables, such as the presence of local governments; and for other social variables, such as population density. We will also take in consideration previous experience with Sars. Our findings corroborate our hypothesis. The difference between the two types of regime is not statistical significant. The Economy, however, seems to play small role: The richer the country is, the longer it takes to adopt restriction measures.