bluuebunny/crossref_metadata_2025_split huggingface dataset:
"Into the great wide open"
Authors: Miettinen Mervi 
Published: March 2020

Open science and research is no longer relevant just for people pursuing an academic career. Instead, it is something that all students entering the university should be increasingly familiar with as they proceed with their studies. Tampere University Library has actively integrated open science into its information literacy teaching, beginning from the first-year orientation studies and continuing throughthe Bachelor’s and Master’s thesis seminars. Following the guidelines provided by the idea of cumulative learning (Maton 2009), the IL teaching at Tampere University Library aims at connecting new knowledge with existing knowledge, effectively building on the students’ previous IL studies throughout their degree.
In addition, the ACRL Framework for Information Literacy (2015) acts as a roadmap for developing IL teaching at Tampere University Library: the Library’s entire teaching team has gathered in workshops and together produced a view of the frames that best suits the University’s students. The frames are awork-in-progress, and the teaching team will continue to work on better adapting the frames. One of the results is the way in which the frames and the threshold concepts within determine the depth inwhich issues such as open science and research are taught at different levels (cf. Sipilä, Miettinen &Tevaniemi, 2019). In order to ensure student engagement, concepts like open science are presented at each level in a way that is relevant to the students’ current studies, beginning with the concept itself and later advancing towards viewing the students as both users and creators of open science.
This presentation will highlight some of the current ways in which open science and research is integrated into the information literacy curriculum at Tampere University Library, and how the ACRL framework can act as a way for library teaching staff to comprehend and develop IL teaching in highereducation.
Educating PhD students for knowledge-driven society
Authors: Renn Oliver , Dolenc Jozica , Betschart Leo , Schnabl Joachim 
Published: March 2020

Universities educate students for working in knowledge-driven societies. Whereas subject-related knowledge is part of every curriculum, institutions of higher education fail to teach systematically how to utilize and benefit from today’s variety of digital tools. Students and researchers are mostly unaware of what they lack to work more effectively and efficiently and to benefit from existing knowledge. Since this lack of awareness is not obvious to students and researchers (unknown unknowns; you cannot miss something that you do not know), it is difficult to convince them that there is a gap that needs to be filled.
In 2014, we decided to tackle this problem by creating and developing the course “Scientific Information Retrieval & Management in Life Sciences and Chemistry”. The unique 2 ECTS course features a multi-level approach to obtain and employ scientific information and to get students information savvy. On one hand, the course demonstrates the bigger picture: We discuss the aspects of scientific writing and publishing, critical choice of data sources, patents, visualisation and design, text mining and data pipelining, knowledge generation, outreach and impact of publications. On the other hand, we highlight an extensive list of field-proven tools that can assist researchers in their daily activities.
We also wanted to foster a lasting impact on how students utilize databases, tools, software, and web services. Thus, at the end of the course students have to write an essay describing their current information workflow or their (un)met information needs. These essays confirm and explain how the students changed their information use, and which parts of the course they may have not understood. Moreover, essays that describe unmet information needs allow us to explore possible solutions and to work with our vendors. In our talk, we will share the concept for the course and report on our experiences.
Library-faculty collaboration in the development of an accredited phd course in transferable academic skills
Authors: Sundstøl Shea Allison , Nordsteien Anita 
Published: March 2020

Background: The PhD course Literature Management and Scientific Communication was establishedin 2019 through a library-faculty collaboration. This is the first accredited generic PhD course at this university, and it provides 5 ECTS credits. In the first course, there werep articipants from four of our eight PhD programs, researching topics spanning from religion to robotics. Our main idea was that bringing PhD candidates from different programs together for such a course may add extra value in the form of enhancing communication and understanding across the disciplines.
Methods: The study has a mixed methods design. A preliminary survey was conducted in 2017 to revealthe PhD candidates’ information needs, which provided a basis for planning the course content. To examine the candidates’ learning outcomes and further improvements for future courses, NVivo was used to analyse observations that were recorded during the course, in addition to the participants’ course essays and evaluation forms.
Results: The 2017 survey had a response rate of 43% (n = 91). More than 50% of the respondents expressed a need for library courses in literature searching, systematic reviews, research data management and the publishing process. The PhD course was designed based on these findings, and we overbooked the course having accepted 20 participants, including 5 international candidates. The main finding was that several of the participants found the course surprisingly useful to their research and to their career plans. However, there were widely varying opinions about including such a diverse group.
Discussion: Having a generic course for early-stage researchers from such a diversity of fields was challenging, and the article discusses several issues to consider for future courses. Most importantly, the prior knowledge was vastly different among the participants. This emphasizes the need for increased library-faculty collaboration to reach out to all PhD candidates in an early stage.
Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout
Authors: Ziegler Michael , Knoll Sarah , Köhler Heinz-R. , Tisler Selina , Huhn Carolin , Zwiener Christian , Triebskorn Rita 
Published: March 2020

BackgroundOver the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin reuptake inhibitor, is one of the most commonly found. Given citalopram is specifically designed to alter mood and behaviour in humans, there is growing concern it can adversely affect the behaviour on non-target wildlifeMethodsIn our study, brown trout were exposed to citalopram (nominal concentrations: 1, 10, 100, 1000 µg/L) in two different life stages. Larvae were exposed at 7 and 11 °C from the eyed ova stage until 8 weeks post yolk sac consumption, and juvenile brown trout were exposed for 4 weeks at 7 °C. At both stages we measured mortality, weight, length, tissue citalopram concentration, behaviour during exposure and behaviour in a stressfull environment. For brown trout larvae additionally hatching rate and heart rate, and for juvenile brown trout the tissue cortisol concentration were assessed.ResultsDuring the exposure, both larvae and juvenile fish exposed to the highest test concentration of citalopram (1 mg/L) had higher swimming activity and spent longer in the upper part of the aquaria compared to control fish, which is an indicator for decreased anxiety. Most probably due to the higher swimming activity during the exposure, the juveniles and larvae exposed to 1 mg/L citalopram showed decreased weight and length. Additionally, in a stressful artificial swimming measurement device, brown trout larvae displayed the anxiolytic effect of the antidepressant by reduced swimming activity during this stress situation, already at concentrations of 100 µg/L citalopram. Chemical analysis of the tissue revealed rising citalopram tissue concentrations with rising exposure concentrations. Tissue concentrations were 10 times higher in juvenile fish compared to brown trout larvae. Fish plasma concentrations were calculated, which exceeded human therapeutic levels for the highest exposure concentration, matching the behavioural results. Developmental parameters like hatching rate and heart rate, as well as mortality and tissue cortisol content were unaffected by the antidepressant. Overall, we could trace the pharmacological mode of action of the antidepressant citalopram in the non-target organism brown trout in two different life stages.
Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens
Authors: Jadhav Rahul Laxman , Sonwalkar Sonali Gulab , Patil Manisha Vyankatrao , Shaikh Siraj N. , Belhekar Santosh N. 
Published: March 2020

Aim: The aim this research work is to formulate and characterize Poly Sulfoxyamine Grafted Chitosan Coated contact Lens.
Methodology: Poly Sulfoxyamine Grafted Chitosan was used for coating the Lens & converting it in to Antimicrobial Lenses. Poly Sulfoxyamine Grafted Chitosan was performed in the presence of pyridine and further treatment with ammonia during reaction of Thionyl chloride & chitosan. The UV light interference, visible light transmission and antimicrobial evaluation were studied.
Results: The results indicate that Contact lenses prepared with Modified Poly Sulfoxyamine Grafted Chitosan absorbed some UV radiation & does not interfere with visible region. Due to the antimicrobial activity of modified Chitosan, the growth and transmission of micro organisms are reduces in coated Lens as compared to uncoated Lens.
Conclusion: On basis of the results we concluded that Modified Poly Sulfoxyamine Grafted Chitosan might be used as coating material or material for making contact Lenses which will be less susceptible for microbial contamination.
Light‐Driven Liquid Crystalline Networks and Soft Actuators with Degree‐of‐Freedom‐Controlled Molecular Motors
Authors: Lan Ruochen , Sun Jian , Shen Chen , Huang Rui , Zhang Zhongping , Ma Cong , Bao Jinying , Zhang Lanying , Wang Ling , Yang Dengke , Yang Huai 
Published: March 2020

AbstractDesign and fabrication of photomechanical soft actuators has attracted intense scientific interest because of their potential in the manufacture of untethered intelligent soft robots and advanced functional devices. Trifunctional and monofunctional polymerizable molecular motors are judiciously designed and synthesized. Novel light‐driven liquid crystalline networks (LCN) are prepared by crosslinking overcrowded‐alkene‐based molecular motors with different degrees of freedom into the anisotropic LCN. The photoisomerization and thermal helix inversion of light‐driven molecular motors are reversible when only the upper part of the molecular motor is linked to the network, endowing the LCN film with remarkable photoactive performance. However, photochemical geometric change of the light‐driven molecular motor does not work after crosslinking both the upper and lower part of the motor by polymer chains. Interestingly, it is found that the fastened motor can transfer the light energy into localized heat instead of performing photoisomerization. The light‐driven molecular‐motor‐based LCN soft actuators are demonstrated to function as a grasping hand, where the continuous motions of grasping, moving, lifting, and releasing an object are successfully achieved. This work may provide inspiration to the preparation of next‐generation photoactive advanced functional materials toward their wide applications in the areas of photonics, optoelectronics, soft robotics, and beyond.
How To Quantify the Efficiency Potential of Neat Perovskite Films: Perovskite Semiconductors with an Implied Efficiency Exceeding 28%
Authors: Stolterfoht Martin , Grischek Max , Caprioglio Pietro , Wolff Christian M. , Gutierrez‐Partida Emilio , Peña‐Camargo Francisco , Rothhardt Daniel , Zhang Shanshan , Raoufi Meysam , Wolansky Jakob , Abdi‐Jalebi Mojtaba , Stranks Samuel D. , Albrecht Steve , Kirchartz Thomas , Neher Dieter 
Published: March 2020

AbstractPerovskite photovoltaic (PV) cells have demonstrated power conversion efficiencies (PCE) that are close to those of monocrystalline silicon cells; however, in contrast to silicon PV, perovskites are not limited by Auger recombination under 1‐sun illumination. Nevertheless, compared to GaAs and monocrystalline silicon PV, perovskite cells have significantly lower fill factors due to a combination of resistive and non‐radiative recombination losses. This necessitates a deeper understanding of the underlying loss mechanisms and in particular the ideality factor of the cell. By measuring the intensity dependence of the external open‐circuit voltage and the internal quasi‐Fermi level splitting (QFLS), the transport resistance‐free efficiency of the complete cell as well as the efficiency potential of any neat perovskite film with or without attached transport layers are quantified. Moreover, intensity‐dependent QFLS measurements on different perovskite compositions allows for disentangling of the impact of the interfaces and the perovskite surface on the non‐radiative fill factor and open‐circuit voltage loss. It is found that potassium‐passivated triple cation perovskite films stand out by their exceptionally high implied PCEs > 28%, which could be achieved with ideal transport layers. Finally, strategies are presented to reduce both the ideality factor and transport losses to push the efficiency to the thermodynamic limit.
Lattice‐Matching Structurally‐Stable 1D@3D Perovskites toward Highly Efficient and Stable Solar Cells
Authors: Liu Peng , Xian Yeming , Yuan Weinan , Long Yi , Liu Kun , Rahman Naveed Ur , Li Wenzhe , Fan Jiandong 
Published: March 2020

AbstractThe stability of perovskite solar cells (PSCs) has been identified to be the bottleneck toward their industrialization. With the aim of tackling this challenge, a 1D PbI2‐bipyridine (BPy)(II) perovskite is fabricated, which is shown to be capable of in situ assembly of a 1D@3D perovskite that is promoted by a PbI2‐dimethyl sulfoxide complex with a skeletal linear chain structure. The as‐prepared 1D@3D perovskite is observed to demonstrate extremely high stability under external large electric fields in humid environments by means of an in situ characterization technique. This stability is associated with its well lattice‐matching heterojunction structure between 1D and 3D heterojunction domains. Importantly, ion migration is alleviated through blocking of the ion‐migration channels. Accordingly, the 1D@3D hybrid PSC shows a power conversion efficiency of 21.18% maintaining remarkably high long‐term stability in the presence of water, illumination, and external electric fields. This rational design and microstructure study of 1D@3D perovskites provides a new paradigm that may enable higher efficiency and stability of PSCs.
Intracellular Reactions Promoted by Bis(histidine) Miniproteins Stapled Using Palladium(II) Complexes
Authors: Learte‐Aymamí Soraya , Vidal Cristian , Gutiérrez‐González Alejandro , Mascareñas José L. 
Published: March 2020

AbstractThe generation of catalytically active metalloproteins inside living mammalian cells is a major research challenge at the interface between catalysis and cell biology. Herein we demonstrate that basic domains of bZIP transcription factors, mutated to include two histidine residues at i and i+4 positions, react with palladium(II) sources to generate catalytically active, stapled pallado‐miniproteins. The resulting constrained peptides are efficiently internalized into living mammalian cells, where they perform palladium‐promoted depropargylation reactions without cellular fixation. Control experiments confirm the requirement of the peptide scaffolding and the palladium staple for attaining the intracellular reactivity.
Tumor‐Specific Chemotherapy by Nanomedicine‐Enabled Differential Stress Sensitization
Authors: Yang Bowen , Chen Yu , Shi Jianlin 
Published: March 2020

AbstractMost of current nanomedicines are administrated intravenously to favour tumor accumulation through enhanced permeability and retention (EPR) effect, which, however, suffers from several drawbacks such as low drug bioavailability and severe side effect. In this work, we have constructed a doxorubicin(Dox)‐based liposomal nanosystem for tumor‐specific chemotherapy, by enabling differential stress sensitization between cancer and normal cells for restricting the chemodrug toxicity exclusively in tumor regions. 2‐Deoxy‐D‐glucose (2DG) was loaded in the nanoliposome to inhibit glycolysis of cancer cells, which works in synergy with the co‐loaded chemodrug Dox to promote mitochondrial depolarization and subsequent apoptosis. In addition, the starvation effect of 2DG can counteract the toxicity of Dox in normal cells and thus mitigates the harmful side effect of chemotherapy. It is expected that such a differential stress sensitization strategy may greatly benefit future nanomedicine design.
Nickel‐Catalyzed Cross‐Coupling of Sulfonamides With (Hetero)aryl Chlorides
Authors: McGuire Ryan T. , Simon Connor M. , Yadav Arun A. , Ferguson Michael J. , Stradiotto Mark 
Published: March 2020

AbstractThe development of Ni‐catalyzed C−N cross‐couplings of sulfonamides with (hetero)aryl chlorides is reported. These transformations, which were previously achievable only with Pd catalysis, are enabled by use of air‐stable (L)NiCl(o‐tol) pre‐catalysts (L=PhPAd‐DalPhos and PAd2‐DalPhos), without photocatalysis. The collective scope of (pseudo)halide electrophiles (X=Cl, Br, I, OTs, and OC(O)NEt2) demonstrated herein is unprecedented for any reported catalyst system for sulfonamide C−N cross‐coupling (Pd, Cu, Ni, or other). Preliminary competition experiments and relevant coordination chemistry studies are also presented.
Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma
Authors: Tiniakou Eleni , Fava Andrea , McMahan Zsuzsanna H. , Guhr Tara , O'Meally Robert N. , Shah Ami A. , Wigley Fredrick M. , Cole Robert N. , Boin Francesco , Darrah Erika 
Published: March 2020

ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality. Anti–topo I antibodies (ATAs) are associated with specific HLA–DRB1 alleles, and the frequency of HLA–DR–restricted topo I–specific CD4+ T cells is associated with the presence, severity, and progression of ILD. Although this strongly implicates the presentation of topo I peptides by HLA–DR in scleroderma pathogenesis, the processing and presentation of topo I has not been studied.MethodsWe developed a natural antigen processing assay (NAPA) to identify putative CD4+ T cell epitopes of topo I presented by monocyte‐derived dendritic cells (mo‐DCs) from 6 ATA‐positive patients with scleroderma. Mo‐DCs were pulsed with topo I protein, HLA–DR–peptide complexes were isolated, and eluted peptides were analyzed by mass spectrometry. We then examined the ability of these naturally presented peptides to induce CD4+ T cell activation in 11 ATA‐positive and 11 ATA‐negative scleroderma patients.ResultsWe found that a common set of 10 topo I epitopes was presented by Mo‐DCs from scleroderma patients with diverse HLA–DR variants. Sequence analysis revealed shared peptide‐binding motifs within the HLA–DRβ chains of ATA‐positive patients and a subset of topo I epitopes with distinct sets of anchor residues capable of binding to multiple different HLA–DR variants. The NAPA‐derived epitopes elicited robust CD4+ T cell responses in 73% of ATA‐positive patients (8 of 11), and the number of epitopes recognized correlated with ILD severity (P = 0.025).ConclusionThese findings mechanistically implicate the presentation of a convergent set of topo I epitopes in the development of scleroderma.
Altered Repertoire Diversity and Disease‐Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients
Authors: Hanson Aimee L. , Nel Hendrik J. , Bradbury Linda , Phipps Julie , Thomas Ranjeny , Lê Cao Kim‐Anh , Kenna Tony J. , Brown Matthew A. 
Published: March 2020

ObjectiveAnkylosing spondylitis (AS) is a common spondyloarthropathy primarily affecting the axial skeleton and strongly associated with HLA–B*27 carriage. Genetic evidence implicates both autoinflammatory processes and autoimmunity against an HLA–B*27–restricted autoantigen in immunopathology. In addition to articular symptoms, up to 70% of AS patients present with concurrent bowel inflammation, suggesting that adverse interactions between a genetically primed host immune system and the gut microbiome contribute to the disease. Accordingly, this study aimed to characterize adaptive immune responses to antigenic stimuli in AS.MethodsThe peripheral CD4 and CD8 T cell receptor (TCR) repertoire was profiled in AS patients (n = 47) and HLA–B*27–matched healthy controls (n = 38). Repertoire diversity was estimated using the Normalized Shannon Diversity Entropy (NSDE) index, and univariate and multivariate statistical analyses were performed to characterize AS‐associated clonal signatures. Furthermore, T cell proliferation and cytokine production in response to immunogenic antigen exposure were investigated in vitro in peripheral blood mononuclear cells from AS patients (n = 19) and HLA–B*27–matched healthy controls (n = 14).ResultsBased on the NSDE measure of sample diversity across CD4 and CD8 T cell repertoires, AS patients showed increased TCR diversity compared to healthy controls (for CD4 T cells, P = 7.8 × 10−6; for CD8 T cells, P = 9.3 × 10−4), which was attributed to a significant reduction in the magnitude of peripheral T cell expansions globally. Upon in vitro stimulation, fewer T cells from AS patients than from healthy controls expressed interferon‐γ (for CD8 T cells, P = 0.03) and tumor necrosis factor (for CD4 T cells, P = 0.01; for CD8 T cells, P = 0.002). In addition, the CD8 TCR signature was altered in HLA–B*27+ AS patients compared to healthy controls, with significantly expanded Epstein‐Barr virus–specific clonotypes (P = 0.03) and cytomegalovirus‐specific clonotypes (P = 0.02). HLA–B*27+ AS patients also showed an increased incidence of “public” CD8 TCRs, representing identical clonotypes emerging in response to common antigen encounters, including homologous clonotypes matching those previously isolated from individuals with bacterial‐induced reactive arthritis.ConclusionThe dynamics of peripheral T cell responses in AS patients are altered, suggesting that differential antigen exposure and disrupted adaptive immunity are underlying features of the disease.