bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contributing factors that influence medication errors in the prehospital paramedic environment: a mixed-method systematic review protocol
Authors: Walker Dennis , Moloney Clint , SueSee Brendan , Sharples Renee 
Published: December 2019

IntroductionThere is limited reliable research available on medication errors in relation to paramedic practice, with most evidence-based medication safety guidelines based on research in nursing, operating theatre and pharmacy settings. While similarities exist, evidence suggests that the prehospital environment is distinctly different in many aspects. The prevention of errors requires attention to factors from the organisational and regulatory level down to specific tasks and patient characteristics. The evidence available suggests errors may occur in up to 12.76% of medication administrations in some prehospital settings. With multiple sources stating that the errors are under-reported, this represents significant potential for patient harm. This review will seek to identify the factors influencing the occurrence of medication errors by paramedics in the prehospital environment.Methods and analysisThe review will include qualitative and quantitative studies involving interventions or phenomena regarding medication errors or medication safety relating to paramedics (including emergency medical technicians and other prehospital care providers) within the prehospital environment. A search will be conducted using MEDLINE (Ovid), EBSCOhost Megafile Search, the International Committee of Medical Journal Editors trial registry, Google Scholar and the OpenGrey database to identify studies meeting this inclusion criteria, with initial searches commencing 30 September 2019. Studies selected will undergo assessment of methodological quality, with data to be extracted from all studies irrespective of quality. Each stage of study selection, appraisal and data extraction will be conducted by two reviewers, with a third reviewer deciding any unresolved conflicts. The review will follow a convergent integrated approach, conducting a single qualitative synthesis of qualitative and ‘qualitised’ quantitative data.Ethics and disseminationNo ethical approval was required for this review. Findings from this systematic review will be disseminated via publications, reports and conference presentations.
Content reporting of exercise interventions in rotator cuff disease trials: results from application of the Consensus on Exercise Reporting Template (CERT)
Authors: Major Daniel H , Røe Yngve , Grotle Margreth , Jessup Rebecca L , Farmer Caitlin , Småstuen Milada Cvancarova , Buchbinder Rachelle 
Published: December 2019

BackgroundExercise interventions are frequently recommended for patients with rotator cuff disease, but poor content reporting in clinical trials of exercise limits interpretation and replication of trials and clinicians’ ability to deliver effective exercise protocols. The Consensus on Exercise Reporting Template (CERT) was developed to address this problem.ObjectiveTo assess completeness of content reporting of exercise interventions in randomised controlled trials for patients with rotator cuff disease and the inter-rater reliability of the CERT.DesignCritical appraisal.MethodsIndependent pairs of reviewers applied the CERT to all 34 exercise trials from the most recent Cochrane Review evaluating the effect of manual therapy and exercise for patients with rotator cuff disease. We used the CERT Explanation and Elaboration Statement to guide assessment of whether each of the 19-item criteria were clearly described (score 0–19; higher scores indicate better reporting). Percentage agreement and the prevalence and bias adjusted kappa (PABAK) coefficient were used to measure inter-rater reliability.ResultsThe median CERT score was 5 (range 0–16). Percentage agreement was high for 15 items and acceptable for 4 items. The PABAK coefficient indicated excellent (5 items), substantial (11 items) and moderate (3 items) inter-rater agreement.ConclusionThe description of exercise interventions for patients with rotator cuff disease in published trials is poorly reported. Overall, the inter-rater reliability of the CERT is high/acceptable. We strongly encourage journals to mandate use of the CERT for papers reporting trial protocols and results investigating exercise interventions.
Belatacept in kidney transplant patients with systemic lupus erythematosus
Authors: Carrión-Barberà Irene , Fajardo Melissa , Danias George , Tsapepas Demetra , Gartshteyn Yevgeniya , Fernandez Hilda , Askanase Anca 
Published: December 2019

ObjectivesLupus nephritis (LN) requires renal replacement therapy in 10%–30% of patients. About 30% of these patients receive a kidney transplant. Belatacept is a second-generation, selective, T-cell co-stimulator blocker (inhibits cytotoxic, T-lymphocyte antigen 4, CTLA-4) used as an alternative to calcineurin inhibitors (CNI) for maintenance regimens after kidney transplantation. The pathogenic relevance of CTLA-4 inhibition and the favourable cardiovascular profile of belatacept make it an attractive therapeutic option in systemic lupus erythematosus (SLE). Intravenous administration of belatacept ensures therapeutic adherence.MethodsThis retrospective, single-centre study evaluates the outcomes of LN kidney transplant recipients treated with belatacept for reasons not related to SLE at the Columbia University Lupus and Renal Transplant Cohort.ResultsBelatacept was started in six patients on CNI regimens at 15.5±17.1 months following transplantation for LN. In five patients, creatinine levels stabilised 6 months after belatacept, one returned to haemodialysis due to CNI toxicity and pyelonephritis and one relisted for a kidney transplant following acute cellular rejection and cortical necrosis. Five patients are followed for extrarenal lupus; no extrarenal manifestations were documented in the other two patients. Data on SLE disease activity pre-belatacept and post-belatacept were available and scored in three patients using the SLE Disease Activity Index Glucocorticosteroid Index (SLEDAI-2KG), which accounts for clinical and laboratory manifestations, as well as steroid dose. Mean SLEDAI-2KG decreased from 13 to 7.6.ConclusionBelatacept in LN kidney transplant recipients may decrease extrarenal manifestations, attenuate CNI toxicity and stabilise allograft function, providing a better alternative to CNI regimens. Furthermore, these data suggest that belatacept, although initiated for reasons not related to SLE, might have a beneficial effect in SLE.
A Novel Material Fluorescence Probe Based on Covalently Functionalized Graphene Oxide by Aminocoumarin for Detection of CN−
Authors: Ma Wenhui , Yu Zhaochuan , Li Zhongcai , Wen Jing , Zhao Baoru , Zhang Yong 
Published: December 2019

Owing to the hazardness, the sensitive and selective detection of cyanide (CN−) in water or water-containing systems has still been a puzzle plaguing scientists all around the world. In this paper, a novel fluorescence probe based on covalently functionalized graphene oxide (GO) by aminocoumarin for highly selective detection of CN− in deionized water was prepared under the action of EDC/NHS. This probe bears aminocoumarin group as the recognition site and fluorophore, and its fluorescence quantum yield is increased by 0.07. Simultaneously, by loading on GO, the dispersibility, selectivity and reversibility were soundly improved, which facilitated the detection process. The fluorescence spectra showed that the probe has high selectivity and sensitivity for cyanide, and has potential application in real water.
Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model
Authors: MacFarland Suzanne P. , Naraparaju Koumudi , Iyer Radhika , Guan Peng , Kolla Venkatadri , Hu Yuxuan , Tan Kai , Brodeur Garrett M. 
Published: December 2019

Abstract
TrkB with its ligand, brain-derived neurotrophic factor (BDNF), are overexpressed in the majority of high-risk neuroblastomas (NB). Entrectinib is a novel pan-TRK, ALK, and ROS1 inhibitor that has shown excellent preclinical efficacy in NB xenograft models, and recently it has entered phase 1 trials in pediatric relapsed/refractory solid tumors. We examined entrectinib-resistant NB cell lines to identify mechanisms of resistance. Entrectinib-resistant cell lines were established from five NB xenografts initially sensitive to entrectinib therapy. Clonal cell lines were established in increasing concentrations of entrectinib and had &gt;10X increase in IC50. Cell lines underwent genomic and proteomic analysis using whole-exome sequencing, RNA-Seq, and proteomic expression profiling with confirmatory RT-PCR and Western blot analysis. There was no evidence of NTRK2 (TrkB) gene mutation in any resistant cell lines. Inhibition of TrkB was maintained in all cell lines at increasing concentrations of entrectinib (target independent). PTEN pathway downregulation and ERK/MAPK pathway upregulation were demonstrated in all resistant cell lines. One of these clones also had increased IGF1R signaling, and two additional clones had increased P75 expression, which likely increased TrkB sensitivity to ligand. In conclusion, NB lines overexpressing TrkB developed resistance to entrectinib by multiple mechanisms, including activation of ERK/MAPK and downregulation of PTEN signaling. Individual cell lines also had IGF1R activation and increased P75 expression, allowing preservation of downstream TrkB signaling in the presence of entrectinib. An understanding of changes in patterns of expression can be used to inform multimodal therapy planning in using entrectinib in phase II/III trial planning.
High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets
Authors: Shao Xiaoshan M. , Bhattacharya Rohit , Huang Justin , Sivakumar I.K. Ashok , Tokheim Collin , Zheng Lily , Hirsch Dylan , Kaminow Benjamin , Omdahl Ashton , Bonsack Maria , Riemer Angelika B. , Velculescu Victor E. , Anagnostou Valsamo , Pagel Kymberleigh A. , Karchin Rachel 
Published: December 2019

AbstractComputational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins can be used to predict patient response to cancer immunotherapy. Current neoantigen predictors focus on in silico estimation of MHC binding affinity and are limited by low predictive value for actual peptide presentation, inadequate support for rare MHC alleles, and poor scalability to high-throughput data sets. To address these limitations, we developed MHCnuggets, a deep neural network method that predicts peptide–MHC binding. MHCnuggets can predict binding for common or rare alleles of MHC class I or II with a single neural network architecture. Using a long short-term memory network (LSTM), MHCnuggets accepts peptides of variable length and is faster than other methods. When compared with methods that integrate binding affinity and MHC-bound peptide (HLAp) data from mass spectrometry, MHCnuggets yields a 4-fold increase in positive predictive value on independent HLAp data. We applied MHCnuggets to 26 cancer types in The Cancer Genome Atlas, processing 26.3 million allele–peptide comparisons in under 2.3 hours, yielding 101,326 unique predicted immunogenic missense mutations (IMM). Predicted IMM hotspots occurred in 38 genes, including 24 driver genes. Predicted IMM load was significantly associated with increased immune cell infiltration (P &lt; 2 × 10−16), including CD8+ T cells. Only 0.16% of predicted IMMs were observed in more than 2 patients, with 61.7% of these derived from driver mutations. Thus, we describe a method for neoantigen prediction and its performance characteristics and demonstrate its utility in data sets representing multiple human cancers.
Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer
Authors: Li Jinyang , Yuan Salina , Norgard Robert J. , Yan Fangxue , Yamazoe Taiji , Blanco Andrés , Stanger Ben Z. 
Published: December 2019

Abstract
Although immune checkpoint blockade (ICB) improves clinical outcome in several types of malignancies, pancreatic ductal adenocarcinoma (PDA) remains refractory to this therapy. Preclinical studies have demonstrated that the relative abundance of suppressive myeloid cells versus cytotoxic T cells determines the efficacy of combination immunotherapies, which include ICB. Here, we evaluated the role of the ubiquitin-specific protease 22 (USP22) as a regulator of the immune tumor microenvironment (TME) in PDA. We report that deletion of USP22 in pancreatic tumor cells reduced the infiltration of myeloid cells and promoted the infiltration of T cells and natural killer (NK) cells, leading to an improved response to combination immunotherapy. We also showed that ablation of tumor cell–intrinsic USP22 suppressed metastasis of pancreatic tumor cells in a T-cell–dependent manner. Finally, we provide evidence that USP22 exerted its effects on the immune TME by reshaping the cancer cell transcriptome through its association with the deubiquitylase module of the SAGA/STAGA transcriptional coactivator complex. These results indicated that USP22 regulates immune infiltration and immunotherapy sensitivity in preclinical models of pancreatic cancer.
Treatment of chronic osteoarthritic hip pain with phenol neurolysis of the obturator nerve Quadfen 1
Authors: Crema Chiara Maria Thá , Magario Luiza Previato Trevisan , Santos Ana Paula Bertole Cirino dos , Riberto Marcelo 
Published: December 2019

The conservative treatment of osteoarthritis (OA) of the hip is essentially symptomatic, seeking to relieve pain and optimize function. Despite presenting great clinical effect, hip arthroplasty may have restrictions, and in these situations, the neurolytic blockade of the anterior branch of the obturator nerve can be a therapeutic alternative, since it stops the afferent pain from the hip joint. Objective: To describe the results of treating patients with severe OA of the hip by applying phenol to the obturator nerve. Method: Twelve consecutive patients with OA of the hip, refractory to conservative treatment, were recruited to have the obturator nerve localized through electrostimulation and blocked with phenol. They were evaluated in terms of pain intensity via the visual analogue scale (VAS), pressure dolorimetry in the medial and lateral gluteus medius, gluteus minimus, and piriformis, and quality of life by the Harris Hip Score (HHS) at baseline (BL) after 1 (M1), 2 (M2), and 6 months (M6). Results: The patients were between 30 and 72 years old with an avarege of 47.5 ± 1.7 years old, 5 of them were women. Three patients were excluded for not being able to come for follow up evaluations. VAS values vaieded from 8.2 ±.0.9 at BL to 6.6 ± 1.7 at M1, 6.5 ± 1.7 at M2, and 7.3 ± 1 in M6 (p=0.0094). As to the HHS, the values were BL:33.27 ± 2.9; M1:39.2 ± 6.4; M2:40.2 ± 8.1, and M6: 38.8 ± 9.7 in the final evaluation (p=0,040). For dolorimetry, non significant variation was BL: 11±5.7, M1: 7.9±2.2; M2: 10.9±5.6; M6: 8.1 ± 1.6 (p 0.69). Conclusion: The application of phenol to the anterior branch of the obturator nerve can be an alternative in the treatment of severe OA of the hip in patients with restrictions to Total Hip Replacement (THR), since it reduces pain and improves quality of life.
Individual Lesion-Level Meta-Analysis Comparing Various Doses of Intracoronary Bolus Injection of Adenosine With Intravenous Administration of Adenosine for Fractional Flow Reserve Assessment
Authors: Wijntjens Gilbert W.M. , van Uffelen Ellen L. , Echavarría-Pinto Mauro , Casadonte Lorena , Stegehuis Valérie E. , Murai Tadashi , Marques Koen M.J. , Yoon Myeong-Ho , Tahk Seung-Jea , Casella Gianni , Leone Antonio M. , López Palop Ramón , Schlundt Christian , Rivero Fernando , Petraco Ricardo , Fearon William F. , Johnson Nils P. , Jeremias Allen , Koo Bon-Kwon , Piek Jan J. , van de Hoef Tim P. 
Published: December 2019

Background:
Intravenous infusion of adenosine is considered standard practice for fractional flow reserve (FFR) assessment but is associated with adverse side-effects and is time-consuming. Intracoronary bolus injection of adenosine is better tolerated by patients, cheaper, and less time-consuming. However, current literature remains fragmented and modestly sized regarding the equivalence of intracoronary versus intravenous adenosine. We aim to investigate the relationship between intracoronary adenosine and intravenous adenosine to determine FFR.

Methods:
We performed a lesion-level meta-analysis to compare intracoronary adenosine with intravenous adenosine (140 µg/kg per minute) for FFR assessment. The search was conducted in accordance to the Preferred Reporting for Systematic Reviews and Meta-Analysis statement. Lesion-level data were obtained by contacting the respective authors or by digitization of scatterplots using custom-made software. Intracoronary adenosine dose was defined as; low: <40 µg, intermediate: 40 to 99 µg, and high: ≥100 µg.

Results:

We collected 1972 FFR measurements (1413 lesions) comparing intracoronary with intravenous adenosine from 16 studies. There was a strong correlation (correlation coefficient =0.915;
P
<0.001) between intracoronary-FFR and intravenous-FFR. Mean FFR was 0.81±0.11 for intracoronary adenosine and 0.81±0.11 for intravenous adenosine (
P
<0.001). We documented a nonclinically relevant mean difference of 0.006 (limits of agreement: −0.066 to 0.078) between the methods. When stratified by the intracoronary adenosine dose, mean differences between intracoronary and intravenous-FFR amounted to 0.004, 0.011, or 0.000 FFR units for low-dose, intermediate-dose, and high-dose intracoronary adenosine, respectively.

Conclusions:
The present study documents clinically irrelevant differences in FFR values obtained with intracoronary versus intravenous adenosine. Intracoronary adenosine hence confers a practical and patient-friendly alternative for intravenous adenosine for FFR assessment.
Did Paul Really Think He Wasn’t Going to Die?
Authors: Doole J. Andrew 
Published: December 2019

AbstractIt is often claimed that Paul expected the Lord to return in glory within his lifetime, based in part on the text of 1 Thess 4:13–18. Those who have a theological interest in denying Paul’s mistaken optimism have to bend over backwards to explain why this wasn’t the case. The use of the First Person Plural in this passage however may be indicative that Paul was not actually making this claim for himself at all. Both the content and the context suggest rather that Paul, Silvanus and Timothy were providing the Thessalonian Christians with a “soundbite” for mutual and reciprocal encouragement when they met as a community. Indeed, Paul may have used First Person Plural soundbites throughout his ministry.
The ‘Islamic’ Deployed
Authors: Emon Anver M. 
Published: December 2019

Abstract
This Fieldnote challenges scholars of Islam and Muslims to consider how the production of knowledge on Islam and Muslims has long been, and continues to be, intimately associated with projects of governance, whether by the modern state or premodern regime. The present is simply a particularly robust historical period during which, wherever one might stand on the political spectrum, the study of Islam is undertaken in the shadow of the state—a disaggregated project of law and justice, border control, national security, and regulation. This Fieldnote recasts Islam and Muslim in an adjectival sense—‘Islamic’ and ‘Muslim’—in order to highlight their variability in relation to the purposes for which they are deployed. To better understand the dynamics by which the ‘Islamic’ is deployed for purposes of state projects, this Fieldnote outlines four registers of analysis—time, space, scale, and rhetoric—to inspire new research on the production of knowledge in the academic study of Islam and Muslims today.
Zheng He’s Military Interventions in South Asia, 1405–1433
Authors: Sen Tansen 
Published: December 2019

Abstract
By examining the activities of Zheng He and members of his expeditions at the Malabar Coast, Sri Lanka, and Bengal, this article argues that the Yongle emperor wanted to exert military power in South Asia in order to legitimize his usurpation at the Ming court. The essay analyzes Zheng He’s intervention in the dispute between Calicut and Cochin, the armed conflict in Sri Lanka in 1410-11, and the expedition’s involvement in a dispute between Bengal and its neighboring polity, Jaunpur. These episodes in South Asia make it difficult to accept the modern representations of the Zheng He expeditions as diplomatic missions intended to promote peace and harmony. Rather, they were, as the essay contends, part of the Yongle emperor’s aim to establish hegemony over “all the known world under the Heaven” or the tianxia.
Latino grandparents’ perception of disagreements with parents in children’s leisure time physical activity
Authors: Xie Hui , Caldwell Linda L , Loy Steven 
Published: December 2019

Background: Latino grandparents are often involved in the care and rearing of grandchildren and may help parents in promoting children’s leisure time physical activity (LTPA). However, potential disagreements between grandparents and parents may undermine their collaboration and subsequently their support for children’s LTPA. Aim: The purpose of this study was to explore Latino grandparents’ perception of disagreements with parents in children’s (age 2–12) LTPA. Methods: Qualitative data were collected from 53 Latino grandparents in Los Angeles County, USA, using four semi-structured focus groups and 26 semi-structured interviews. Transcribed data were systematically and iteratively coded and analysed. Results: Many Latino grandparents disagreed with parents’ sedentary lifestyle, permissive parenting and lack of support for children’s LTPA. In addition, Latino grandparents described disagreement with parents in specific issues such as children’s LTPA options and safety during LTPA. Conclusion: There were disagreements between Latino grandparents and parents concerning children’s LTPA. Health researchers and practitioners should be aware of those disagreements and consider using education/intervention programmes to reduce the tension between Latino grandparents and parents and increase their collaborative support for children’s LTPA.