bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of mushroom-shaped allograft for unstable proximal humerus fractures
Authors: Dankl Lukas , Schmoelz Werner , Hoermann Romed , Euler Simon 
Published: December 2020

AbstractIntroductionProximal humerus fractures are common injuries of the elderly. Different treatment options, depending on fracture complexity and stability, have been recommended in the literature. Particularly for varus displaced fractures with a lack of medial support, and patients suffering from osteoporosis, structural allografts can be used to enhance the stability of the construct. An individually shaped allograft has been suggested in the literature and investigated in a clinical setting. However, biomechanical properties have yet to be evaluated.Materials and methodsTwenty-four fresh-frozen humeri and 12 femoral heads were obtained, and an unstable three-part fracture of the humeral head was simulated. Fracture fixation was achieved by using a locking plate in both groups. In the test group, a mushroom-shaped allograft was tailored out of a femoral head to individually fit the void inside the humeral head. Specimens were fitted with a 3D motion analysis system and cyclically loaded with a stepwise increasing load magnitude in a varus-valgus bending test until failure or up to a maximum of 10,000 load cycles.ResultsThe mushroom group reached a significantly higher number of load cycles (8342; SD 1,902; CI 7133–9550) compared to the control group (3475; SD 1488; CI 2530–4420;p < 0.001). Additionally, the test group showed significantly higher stiffness values concerning all observational points (p < 0.001).ConclusionThis mushroom-shaped allograft in combination with a locking plate significantly increased load to failure as well as stiffness of the construct when exposed to varus-valgus bending forces. Therefore, it might be a viable option for surgical treatment of unstable and varus displaced proximal humerus fractures to superiorly prevent loss of reduction and varus collapse.
The development of the concept of uniform convergence in Karl Weierstrass’s lectures and publications between 1861 and 1886
Authors: Viertel Klaus 
Published: December 2020

AbstractThe history of uniform convergence is typically focused on the contributions of Cauchy, Seidel, Stokes, and Björling. While the mathematical contributions of these individuals to the concept of uniform convergence have been much discussed, Weierstrass is considered to be the actual inventor of today’s concept. This view is often based on his well-known article from 1841. However, Weierstrass’s works on a rigorous foundation of analytic and elliptic functions date primarily from his lecture courses at the University of Berlin up to the mid-1880s. For the history of uniform convergence, these lectures open up an independent branch of development that is disconnected from the approaches of the previously mentioned authors; to my knowledge, Weierstraß never explicitly referred to Cauchy’s continuity theorem (1821 or 1853) or to Seidel’s or Stokes’s contributions (1847). In the present article, Weierstrass’s contributions to the development of uniform convergence will be discussed, mainly based on lecture notes made by Weierstrass’s students between 1861 and the mid-1880s. The emphasis is on the notation and the mathematical rigor of the introductions to the concept, leading to the proposal to re-date the famous 1841 article and thus Weierstrass’s first introduction of uniform convergence.
Some like it, some do not: behavioral responses and central processing of olfactory–trigeminal mixture perception
Authors: Müschenich Franziska S. , Sichtermann Thorsten , Di Francesco Maria Elisa , Rodriguez-Raecke Rea , Heim Lennart , Singer Marco , Wiesmann Martin , Freiherr Jessica 
Published: December 2020

AbstractExploring the potential of eucalyptol as a masking agent for aversive odors, we found that eucalyptol masks the olfactory but not the trigeminal sensation of ammonia in a previous study. Here, we further investigate the processing of a mixture consisting of eucalyptol and ammonia, two olfactory–trigeminal stimuli. We presented the two pure odors and a mixture thereof to 33 healthy participants. The nostrils were stimulated alternately (monorhinal application). We analyzed the behavioral ratings (intensity and pleasantness) and functional brain images. First, we replicated our previous finding that, within the mixture, the eucalyptol component suppressed the olfactory intensity of the ammonia component. Second, mixture pleasantness was rated differently by participants depending on which component dominated their mixture perception. Approximately half of the volunteers rated the eucalyptol component as more intense and evaluated the mixture as pleasant (pleasant group). The other half rated the ammonia component as more intense and evaluated the mixture as unpleasant (unpleasant group). Third, these individual differences were also found in functional imaging data. Contrasting the mixture either to eucalyptol or to both single odors, neural activation was found in the unpleasant group only. Activation in the anterior insula and SII was interpreted as evidence for an attentional shift towards the potentially threatening mixture component ammonia and for trigeminal enhancement. In addition to insula and SII, further regions of the pain matrix were involved when assessing all participant responses to the mixture. Both a painful sensation and an attentional shift towards the unpleasant mixture component complicates the development of an efficient mask because a pleasant perception is an important requirement for malodor coverage.
Perisomatic innervation and neurochemical features of giant pyramidal neurons in both hemispheres of the human primary motor cortex
Authors: Szocsics Péter , Papp Péter , Havas László , Watanabe Masahiko , Maglóczky Zsófia 
Published: December 2020

AbstractBetz cells—the gigantopyramidal neurons found in high amount in the primary motor cortex—are among of the most characteristic neuronal cells. A part of them contains the calcium-binding protein parvalbumin (PV) in primates. However, less is known about these cells in the human motor cortex despite their important role in different neurological disorders. Therefore, the aim of our study was to investigate the neurochemical features and perisomatic input properties of Betz cells in control human samples with short post-mortem interval. We used different microscopic techniques to investigate the primary motor cortex of both hemispheres. The soma size and density, and expression of PV of the Betz cells were investigated. Furthermore, we used confocal fluorescent and electron microscopy to examine their perisomatic input. The soma size and density showed moderate variability among samples and hemispheres. Post-mortem interval and hemispherical localization did not influence these features. Around 70% of Betz cells expressed PV, but in less intensity than the cortical interneurons. Betz neurons receive dense perisomatic input, which are mostly VIAAT- (vesicular inhibitory amino acid transporter) and PV immunopositive. In the electron microscope, we found PV-immunolabelled terminals with asymmetric-like synaptic structure, too. Terminals with morphologically similar synaptic specialisation were also found among vGluT2- (vesicular glutamate transporter type 2) immunostained terminals contacting Betz cells. Our data suggest that Betz cells’ morphological properties showed less variability among subjects and hemispheres than the density of them. Their neurochemical and perisomatic input characteristics support their role in execution of fast and precise movements.
Extrinsic neuromodulation in the rodent olfactory bulb
Authors: Brunert Daniela , Rothermel Markus 
Published: December 2020

AbstractEvolutionarily, olfaction is one of the oldest senses and pivotal for an individual’s health and survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to heavily process sensory information. To adapt to an animal’s needs, OB activity can be influenced by many factors either from within (intrinsic neuromodulation) or outside (extrinsic neuromodulation) the OB which include neurotransmitters, neuromodulators, hormones, and neuropeptides. Extrinsic sources seem to be of special importance as the OB receives massive efferent input from numerous brain centers even outweighing the sensory input from the nose. Here, we review neuromodulatory processes in the rodent OB from such extrinsic sources. We will discuss extrinsic neuromodulation according to points of origin, receptors involved, affected circuits, and changes in behavior. In the end, we give a brief outlook on potential future directions in research on neuromodulation in the OB.
Self-moments stiffening effect and buckling strength of periodic Vierendeel beams
Authors: Penta Francesco 
Published: December 2020

AbstractThis paper deals with the buckling phenomenon of periodic Vierendeel beams. Closed-form solutions for critical loads and deformed shapes are presented. They are built by exploiting several auxiliary solutions obtained for the discrete periodic girder and for a geometrically nonlinear micro-polar equivalent model. In particular, the girder when subjected to sinusoidal self-equilibrated systems of inner bending moments (self-moments) is analysed. The corresponding results are used for solving the large-deflection equilibrium problem of the continuous equivalent model by means of the eigenfunction expansion technique. Girder buckling conditions are then defined in terms of kinematics of the micro-polar model: more precisely, they are attained when special distributions of self-moments, able to bend the continuous system without violating compatibility of shear strains, act in the girder. It is shown that these systems, neglected in the theories presented so far, have a significant stiffening effect on the buckling girder behaviour. Moreover, they are governed by the continuity equation for micro-rotations that is solved in closed form by the Galerkin method, with the micro-polar model eigenfunctions as basis functions. The accuracy of the proposed solutions is verified by comparing them with those achieved by a series of finite element girder models.
The nodal-based floating frame of reference formulation with modal reduction
Authors: Zwölfer Andreas , Gerstmayr Johannes 
Published: December 2020

AbstractIn a recent paper of the authors, a novel nodal-based floating frame of reference formulation (FFRF) for solid finite elements has been proposed. The nodal-based approach bypasses the unhandy inertia shape integrals ab initio, i.e. they neither arise in the derivation nor in the final equations of motion, leading to a surprisingly simple derivation and computer implementation without a lumped mass approximation, which is conventionally employed within commercial multibody codes. However, the nodal-based FFRF has so far been presented without modal reduction, which is usually required for efficient simulations. Hence, the aim of this follow-up paper is to bring the nodal-based FFRF into a suitable form, which allows the incorporation of modal reduction techniques to reduce the overall system size down to the number of modes included in the reduction basis, which further reduces the computational complexity significantly. Moreover, this exhibits a way to calculate the so-called FFRF invariants, which are constant “ingredients” required to set up the FFRF mass matrix and quadratic velocity vector, without integrals and without a lumped mass approximation.
Exceptional performance of multinational suppliers: theory and evidence
Authors: Pham Van , Woodland Alan , Caselli Mauro 
Published: December 2020

AbstractThis paper focuses on an unexamined area of trade—the behaviour of heterogeneous intermediate suppliers facing final producers of different ability and pursuing different strategies. To inform our empirical analysis, we develop a theoretical model to analyse the choice of an intermediate supplier between selling to domestic producers, selling to multinational producers and/or exporting to foreign producers. The model’s predictions are: (i) sufficiently productive firms self-select into supplying to multinationals or exporting, while the most productive firms pursue both strategies, and (ii) the order of preferred strategies between supplying to multinationals and exporting depends on foreign direct investment inflows and export set-up costs. The paper uses firm-level data with rare information about multinational suppliers from 29 countries in Europe and Central Asia in 2002 and 2005 to test these theoretical predictions. The empirical analysis confirms both of our model’s predictions. Moreover, it suggests that multinational suppliers are more likely to have higher required levels of ex-ante labour productivity than exporters, implying that exporting is easier and a more popular choice for firms.
Estimating and Explaining the Prevalence of Tuberculosis for Asylum Seekers Upon Their Arrival in Germany
Authors: Stadtmüller S. , Schröder J. , Ehlers S. 
Published: December 2020

AbstractUp until recently incidences of tuberculosis (TB) had been declining for many years in Germany. The rise in TB cases coincided with a large increase in the number of people applying for asylum. We combine data from various sources to estimate the at-entry prevalence of TB for asylum seekers from 18 countries of origin and rely on survey data to explain the varying risk of suffering from TB. Our results reveal that asylum seekers from Eastern Africa show a much higher risk of suffering from TB than asylum seekers from Afghanistan, Syria, or Iraq. The survey data suggests that asylum seekers from Africa were by far more underprivileged in their respective countries of origin and experienced a higher risk of contracting TB on their way to Germany. Information about the socio-economic situation and the circumstances of the journey to Germany may help to improve TB surveillance.
On Kantian tendencies during the early corona pandemic in Germany
Authors: Feufel Markus A. , Schmid Christine , Westfal Viola 
Published: December 2020

AbstractBased on an ad hoc online survey about risk perception and preventive behaviours, we describe three chronological phases related to how people in Germany perceived the Corona pandemic between March 22 and May 10, 2020. In general, participants reported to be less concerned about their own risk than about the risk faced by others. However, a good portion of those who thought that they themselves were low risk actually wrote about their belief that they nevertheless had a responsibility to behave in ways that benefited others, even if it came at a cost to themselves. In loose reference to Immanuel Kant’s notion that humans have a rational duty to act in a socially responsible manner, we interpret people’s comments about other-regarding behaviour as an initiation of a Kantian tendency during the Corona pandemic. Based on these findings, we suggest that policy makers may do better in times of crisis than nudging, incentivizing, or compelling the public by law. They can perhaps accomplish more by (also) nurturing people’s innate sense of the need for socially responsible action to be taken in order to meet the daunting challenges of present and future crises.
Cold Gas Spraying of Nickel-Titanium Coatings for Protection Against Cavitation
Authors: Mauer Georg , Rauwald Karl-Heinz , Sohn Yoo Jung , Weirich Thomas E. 
Published: December 2020

AbstractCavitation erosion is a sever wear mechanism that takes place in hydrodynamic systems. Examples are turbine vanes of hydropower plants or components of valves and pumps in hydraulic systems. Nickel-titanium shape memory alloys (NiTi) are attractive materials for cavitation-resistant coatings because of their pronounced intrinsic damping mitigating cavitation-induced erosion. In this work, NiTi coatings were produced by cold gas spraying. The phase transformation behaviors of the powder feedstock and the as-sprayed coatings were investigated. Regarding the obtained transformation temperatures, the measured substrate temperatures during spraying rule out that either the shape memory effect or the pseudoelasticity of NiTi could affect the deposition efficiency under the applied conditions of cold gas spraying. Another potential effect is stress-induced amorphization which could occur at the particle–substrate interfaces and impair particle bonding by stress relaxation. Moreover, also oxide formation can be significant. Thus, the presence of amorphous phases and oxides in the near-surface zone of particles bounced off after impact was investigated. Oxidation could be confirmed, but no indication of amorphous phase was found. Besides, also the evolution of local microstrains implies that the substrate temperatures affect the deposition efficiency. These temperatures were significantly influenced by the spray gun travel speed.
Analysis of the influence of process complexity and employee competence on the effect of digital assistance in industrial assembly
Authors: Keller Thimo , Behling Magnus , Stockinger Christopher , Metternich Joachim , Schützer Klaus 
Published: December 2020

AbstractThe diversification of products increases the complexity of production, which intensifies the demands placed on employees. Digital assistance is expected to improve employee performance and flexibility. This paper examines the impact of digital assistance on labor productivity (hourly output) and experience of use in dependence on process complexity and employee competence. Within the framework of an empirical study in the process learning factory CiP of the TU Darmstadt, the effect was quantified using the example of a typical assembly process. This paper presents the concept and the results of the study. After the classification of an assembly task, these results can be used to support the selection decision for a digital assistance system according to cost–benefit aspects.
Automated laser polishing for surface finish enhancement of additive manufactured components for the automotive industry
Authors: Caggiano Alessandra , Teti Roberto , Alfieri Vittorio , Caiazzo Fabrizia 
Published: December 2020

AbstractAdditive manufactured components require polishing to improve their inherently rough surface finish. In this work, an innovative laser polishing process based on wobbling of the laser beam is proposed for surface finish enhancement of additive manufactured parts made of Cr–Cu precipitation hardening steel, widely employed for mechanical components in the automotive industry. Parts were fabricated by selective laser melting and subjected to the innovative laser polishing under different process conditions. Surface characterization was performed by microstructural analysis and surface roughness measurement. Machine learning-based CNN processing of polished surface images was employed for automatic identification of optimal LP condition.
Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?
Authors: Dalhoff Axel 
Published: December 2020

AbstractBackgroundSelective toxicity antibacteribiotics is considered to be due to interactions with targets either being unique to bacteria or being characterized by a dichotomy between pro- and eukaryotic pathways with high affinities of agents to bacterial- rather than eukaryotic targets. However, the theory of selective toxicity oversimplifies the complex modes of action of antibiotics in pro- and eukaryotes.Methods and objectiveThis review summarizes data describing multiple modes of action of antibiotics in eukaryotes.ResultsAminoglycosides, macrolides, oxazolidinones, chloramphenicol, clindamycin, tetracyclines, glycylcyclines, fluoroquinolones, rifampicin, bedaquillin, ß-lactams inhibited mitochondrial translation either due to binding to mitosomes, inhibition of mitochondrial RNA-polymerase-, topoisomerase 2ß-, ATP-synthesis, transporter activities. Oxazolidinones, tetracyclines, vancomycin, ß-lactams, bacitracin, isoniazid, nitroxoline inhibited matrix-metalloproteinases (MMP) due to chelation with zinc and calcium, whereas fluoroquinols fluoroquinolones and chloramphenicol chelated with these cations, too, but increased MMP activities. MMP-inhibition supported clinical efficacies of ß-lactams and daptomycin in skin-infections, and of macrolides, tetracyclines in respiratory-diseases. Chelation may have contributed to neuroprotection by ß-lactams and fluoroquinolones. Aminoglycosides, macrolides, chloramphenicol, oxazolidins oxazolidinones, tetracyclines caused read-through of premature stop codons. Several additional targets for antibiotics in human cells have been identified like interaction of fluoroquinolones with DNA damage repair in eukaryotes, or inhibition of mucin overproduction by oxazolidinones.ConclusionThe effects of antibiotics on eukaryotes are due to identical mechanisms as their antibacterial activities because of structural and functional homologies of pro- and eukaryotic targets, so that the effects of antibiotics on mammals are integral parts of their overall mechanisms of action.
The Legal Characterization of Facts During the Red Terror in Ethiopia: Genocide, War Crimes, or Crimes Against Humanity?
Authors: Yilma Kassahun Molla 
Published: December 2020

AbstractMultiple countries have investigated and prosecuted the perpetrators of crimes committed during the Red Terror in Ethiopia. In bringing the perpetrators to account, each country adopted a unique approach, resulting in a variation in the situation’s legal characterization. The charges against the Red Terror perpetrators in the U.S. were based on violations of immigration laws, while the perpetrators in Ethiopia were charged and convicted of the crime of genocide. In contrast, one suspect, who had already been convicted of genocide by the Ethiopian High Court, has recently been convicted of war crimes by the Hague District Court, the Netherlands. The article investigates whether the Red Terror crimes constitute war crimes, genocide, or crimes against humanity. Accordingly, this analysis shows that while countries have used genocide or war crimes when prosecuting crimes perpetrated during the Red Terror, the best fit to the situation’s legal characterization would be crimes against humanity.
Marking one’s own viewpoint: The Finnish evidential verb+kseni‘as far as I understand’ construction
Authors: Jaakola Minna 
Published: December 2020

AbstractThis article examines evidentiality in the frame of inferential adverbs in written interaction from the perspective of Finnish, a language that does not have evidentiality as a grammatical category. The analysis focuses on six adverbs, such askäsittääkseni‘as far as I understand’ andtietääkseni‘to my knowledge, as far as I know’. Evidentiality and epistemic modality intertwine in their semantics, as these adverbs represent a writer’s access to information, but also indicate her evaluation of its reliability. First, this article offers a description of the interactional functions of these adverbs such as marking a writer’s opinion in contrasts, expressing slight hedging in order to anticipate corrections, to allow space for other opinions, or to create irony. Second, in the framework of cognitive grammar, the analysis focuses on the meaning of the evidential verb+kseniconstruction and the effect of different verb stems on it. These adverbs share similar functions in texts, which is due to their flexible constructional meaning. While varying from lexeme to lexeme, specific evidential and epistemic dimensions can either be foregrounded and relevant in a situation or remain backgrounded and not activated.