bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the Forensic Footprint with Android Accessibility Attacks
Authors: Leguesse Yonas , Vella Mark , Colombo Christian , Hernandez-Castro Julio 
Published: September 2020

Abstract
Android accessibility features include a robust set of tools allowing developers to create apps for assisting people with disabilities. Unfortunately, this useful set of tools can also be abused and turned into an attack vector, providing malware with the ability to interact and read content from third-party apps.
In this work, we are the first to study the impact that the stealthy exploitation of Android accessibility services can have on significantly reducing the forensic footprint of malware attacks, thus hindering both live and post-incident forensic investigations. We show that through Living off the Land (LotL) tactics, or by offering a malware-only substitute for attacks typically requiring more elaborate schemes, accessibility-based malware can be rendered virtually undetectable.
In the LotL approach, we demonstrate accessibility-enabled SMS and command and control (C2) capabilities. As for the latter, we show a complete cryptocurrency wallet theft, whereby the accessibility trojan can hijack the entire withdrawal process of a widely used app, including two-factor authentication (2FA). In both cases, we demonstrate how the attacks result in significantly diminished forensic evidence when compared to similar attacks not employing accessibility tools, even to the extent of maintaining device take-over without requiring malware persistence.
Effect of fracturoscopy on the incidence of surgical site infections post tibial plateau fracture surgery
Authors: Henkelmann Ralf , Krause Matthias , Alm Lena , Glaab Richard , Mende Meinhard , Ull Christopher , Braun Philipp-Johannes , Katthagen Christoph , Gensior Tobias J. , Frosch Karl-Heinz , Hepp Pierre 
Published: September 2020

Abstract
Purpose
Surgical treatment of tibial plateau fracture (TPF) is common. Surgical site infections (SSI) are among the most serious complications of TPF. This multicentre study aimed to evaluate the effect of fracturoscopy on the incidence of surgical site infections in patients with TPF.

Methods
We performed a retrospective multicentre study. All patients with an AO/OTA 41 B and C TPF from January 2005 to December 2014 were included. Patients were divided into three groups: those who underwent arthroscopic reduction and internal fixation (ARIF), and those who underwent open reduction and internal fixation (ORIF) with fracturoscopy, and those treated with ORIF without fracturoscopy. The groups were compared to assess the effect of fracturoscopy. We characterised our cohort and the subgroups using descriptive statistics. Furthermore, we fitted a logistic regression model which was reduced and simplified by a selection procedure (both directions) using the Akaike information criterion (AIC). From the final model, odds ratios and inclusive 95% confidence intervals were calculated.

Results
Overall, 52 patients who underwent fracturoscopy, 48 patients who underwent ARIF, and 2000 patients treated with ORIF were identified. The rate of SSI was 0% (0/48) in the ARIF group and 1.9% (1/52) in the fracturoscopy group compared to 4.7% (93/2000) in the ORIF group (OR = 0.40, p = 0.37). Regression analyses indicated a potential positive effect of fracturoscopy (OR, 0.65; 95% CI, 0.07–5.68; p = 0.69).

Conclusion
Our study shows that fracturoscopy is associated with reduced rates of SSI. Further studies with larger cohorts are needed to investigate this.

Level of evidence
Level III.
FC Sets and Twisters: The Basics of Orbifold Deconstruction
Authors: Bantay Peter 
Published: September 2020

AbstractWe present a detailed account of the properties of $$\text {twister}$$
twister
s and their generalizations, $$\text {FC set}$$

FC set

s, which are essential ingredients of the orbifold deconstruction procedure aimed at recognizing whether a given conformal model may be obtained as an orbifold of another one, and if so, to identify the twist group and the original model. The close analogy with the character theory of finite groups is discussed, and its origin explained.
Biological properties of bone marrow plasma cells influence their recovery in aspirate specimens: impact on classification of plasma cell disorders and potential bias to evaluation of treatment response
Authors: Demyanets Svitlana , Kaider Alexandra , Simonitsch-Klupp Ingrid , Bayer Günther , Subasic Almira , Thalhammer Renate , Esterbauer Harald , Krauth Maria T. , Agis Hermine , Reiter Thomas , Schwarzinger Ilse 
Published: September 2020

AbstractMethods to estimate bone marrow plasma cells (BMPC) basically include histopathology, cytomorphology, and flow cytometry. The present study compares the outcomes of these methods with special focus on the impact of BMPC-specific characteristics on their recovery by either method. Laboratory reports of diagnostic samples from 238 consecutive patients with suspected or known plasma cell disease were retrospectively analyzed. The median (IQR) proportion of BMPC was 30.0% (15.0–70.0%) by histological review (hBMPC), 7.0% (2.0–16.0%) by smear review (sBMPC), and 3.0% (0.8–10.0%) by flow cytometry (fBMPC). The disparity of results between core biopsy and aspirate smear was enhanced in case of poor quality of the smear, increased BM fiber content, higher grade cell atypia, expression of CD56 (all P < 0.0001), the number of cytogenetic aberrations (P = 0.0002), and abnormalities of the MYC gene (P = 0.0002). Conversely, expression of CD19 and a non-clonal plasma cell phenotype were associated with a lower difference between hBMPC and sBMPC (both P < 0.0001). The disparity between the percentages of sBMPC and fBMPC was associated with the quality of the smear (P = 0.0007) and expression of CD56 (P < 0.0001). Our results suggest that the recovery of BMPC in aspirate specimens not only is a matter of sampling quality but also depends on biological cell properties. Aspiration failure due to malignant type features of BMPC may lead to misclassification of plasma cell disorders and represent a bias for the detection of minimal residual disease after therapy.
Genetic research and clinical analysis of deletional Chinese Gγ+(Aγδβ)0 -thalassemia and Southeast Asian HPFH in South China
Authors: Wu Yuanjun , Yao Qianyu , Zhong Ming , Wu Jianying , Xie Longxu , Su Linnan , Yu Fubing 
Published: September 2020

AbstractChinese Gγ+(Aγδβ)0-thalassemia and SEA-HPFH are the most common types of β-globin gene cluster deletion in Chinese population. The aim of the study was to analyze clinical features of deletional Chinese Gγ+(Aγδβ)0-thalassemia and Southeast Asian hereditary persistence of fetal hemoglobin (SEA-HPFH) in South China. A total of 930 subjects with fetal hemoglobin (HbF) level ≥ 2% were selected on genetic research of Chinese Gγ+(Aγδβ)0-thalassemia and SEA-HPFH. The gap polymerase chain reaction was performed to identify the deletions. One hundred cases of Chinese Gγ+(Aγδβ)0-thalassemia were detected, including 90 cases of Chinese Gγ+(Aγδβ)0/βN-thalassemia, 7 cases of Chinese Gγ+(Aγδβ)0 /βN-thalassemia combined with α-thalassemia, 2 cases of Chinese Gγ+(Aγδβ)0-thalassemia combined with β-thalassemia, and 1 case of Chinese Gγ+(Aγδβ)0-thalassemia combined with β-gene mutation. One hundred nine cases of SEA-HPFH were detected, including 97 cases of SEA-HPFH/βN, 9 cases of SEA-HPFH/βN combined with α-thalassemia, 2 cases of SEA-HPFH combined with β-thalassemia, and 1 case of SEA-HPFH combined with β-gene mutation. Statistical analysis indicates significant differences in MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), and HbA2 and HbF levels between Chinese Gγ+(Aγδβ)0-thalassemia heterozygotes and SEA-HPFH heterozygotes (P < 0.001). There are statistical differences in hematological parameters between them. Clinical phenotypic analysis can provide guidance for genetic counseling and prenatal diagnosis.
Wie gut sind Patienten mit entzündlich rheumatischen Erkrankungen gegen Masern geschützt?
Authors: Kiltz U. , Celik A. , Tsiami S. , Baraliakos X. , Andreica I. , Kiefer D. , Bühring B. , Braun J. 
Published: September 2020

Zusammenfassung
Hintergrund
Patienten mit entzündlich rheumatischen Erkrankungen haben aufgrund ihrer Autoimmunerkrankung, aber auch bedingt durch die immunsuppressive Medikation ein erhöhtes Infektrisiko. Obwohl Impfungen in der Primärprophylaxe von Infektionen bekanntermaßen effektiv sind, ist die Impfrate in Deutschland generell zu niedrig. Wegen des zuletzt zunehmenden, teils epidemieartigen Auftretens von Masern ist die Lebendimpfung gegen Masern in Deutschland seit Kurzem gesetzlich vorgeschrieben.

Fragestellung
Wie viele Patienten mit entzündlich rheumatischen Erkrankungen sind aktuell ausreichend gegen Masern geschützt?

Methode
Patienten mit entzündlich rheumatischen Erkrankungen des Rheumazentrums Ruhrgebiet wurden zwischen Dezember 2017 und Oktober 2018 prospektiv und konsekutiv eingeschlossen. Dabei wurden Daten zu Erkrankung und Therapie auf Ebene von Substanzklassen sowie die Impf- und Infektanamnese erhoben. Alle Angaben zu Impfungen wurden im Impfpass kontrolliert. Antikörpertiter gegen Masern wurden mit ELISA bestimmt. Als Schwellenwert für einen ausreichenden Schutz gegen Masern wurden 150 mIU/ml festgelegt.

Ergebnis
Von 975 Patienten konnten 540 (55,4 %) einen Impfausweis vorlegen. Bei 201 Patienten mit Ausweis (37,2 %) lagen dokumentierte Impfungen seit Geburt vor. Insgesamt hatten 45 von 267 nach 1970 geborene Patienten (16,9 %) einen suffizienten Impfschutz gegen Masern. Die anamnestischen Angaben zu einer Masernerkrankung in der Kindheit differenzierten nicht zwischen Patienten mit und ohne protektiven Masern-IgG-Antikörpern. Protektive Masern-IgG-Antikörper wurden bei 901 Patienten von 928 Patienten mit Messung der Masern-IgG-Antikörperspiegel (97,1 %) nachgewiesen. Die unterschiedlichen Wirkprinzipien der aktuellen immunsuppressiven Therapie hatten darauf keinen Einfluss.

Diskussion
Diese Daten zeigen, dass mindestens 2,9 % der Patienten keinen ausreichenden Schutz gegen Masern haben. Interessanterweise hatte die Mehrheit der nach 1970 geborenen Patienten protektive Antikörper trotz fehlenden Impfschutzes gegen Masern. Die Anstrengungen sowohl im primär- als auch im fachärztlichen Bereich sollten dringend verstärkt werden, um eine adäquate Infektionsprophylaxe bei besonders gefährdeten Patienten gewährleisten zu können.
Informal caregiver well-being during and after patients’ treatment with adjuvant chemotherapy for colon cancer: a prospective, exploratory study
Authors: Langenberg S. M. C. H. , Poort H. , Wymenga A. N. M. , de Groot J. W. , Muller E. W. , van der Graaf W. T. A. , Prins J. B. , van Herpen C. M. L. 
Published: September 2020

AbstractIntroductionCaring for a significant other during cancer treatment can be demanding. Little is known about the well-being of informal caregivers of patients with colon cancer. This study aims to examine informal caregiver well-being during adjuvant chemotherapy for colon cancer.Material and methodsThis exploratory longitudinal, prospective study measured the course of informal caregiver burden (Self-Perceived Pressure of Informal Care), distress (Hospital Anxiety and Depression Scale), health-related quality of life (RAND-36), marital satisfaction (Maudsley Marital Questionnaire), social support (Social Support List – Discrepancies), fatigue (Abbreviated Fatigue Questionnaire), and self-esteem (Caregiver Reaction Assessment) before (T0), during (T1), and after (T2) patients’ treatment.ResultsBaseline data of 60 out of 76 eligible dyads (79%) were analyzed. Mean levels of informal caregiver burden and distress improved significantly over time, as did their health-related quality of life and perceived social support. At baseline, 30% and 26.7% of informal caregivers reported moderate-to-high levels of burden and clinically relevant levels of distress, respectively, which changed to 20% and 18.8% at T2. Informal caregiver burden and distress at baseline were the strongest predictors of informal caregiver burden and distress during and following patients’ treatment, respectively.ConclusionWhen informal caregivers and patients experience problems before start of adjuvant chemotherapy, problems seem to improve over time. Approximately 20% of informal caregivers remain burdened and distressed after patients’ end of treatment. Paying attention to baseline distress and burden seems indicated, as these were strong predictors of informal caregivers’ well-being during and after treatment.
Symptommanagement – pflegewissenschaftliche Modelle in der Theorie und Praxis
Authors: Naegele Matthias 
Published: September 2020

Zusammenfassung
Hintergrund
Das Management von krankheits- und therapiebedingten Symptomen ist eine Kernaufgabe onkologischer Pflege. Neben eigener Beratung und Anbieten von Interventionen koordiniert Pflege das multidisziplinäre Team. Chronisch kranke Krebspatienten müssen lernen, ihre Symptome selbst zu managen.

Fragestellung
Welche Faktoren müssen bei der Entwicklung maßgeschneiderter Symptommanagement-Interventionen besonders berücksichtigt werden?

Methode
Die Fragestellung wird literaturgestützt und anhand von praktischen Erfahrungen aufgearbeitet.

Ergebnisse
Das Modell von Dodd et al. stellt die Grundlage des pflegerischen Verständnisses von Symptommanagement dar. Ausgehend von der Symptomerfahrung der Patienten können individuelle Symptommanagement-Interventionen entwickelt werden. Leitend sind dabei die Fragen: Was? Wann? Wo? Warum? Wie viel? Für wen? Wie? Die Evaluation findet durch Erheben des funktionellen oder emotionalen Status, der Fähigkeit zur Selbstpflege, Kosten, Lebensqualität, sowie Morbidität und Mortalität statt.

Schlussfolgerung
Für eine erfolgreiche Symptommanagement-Intervention ist multidisziplinäres Zusammenarbeiten erforderlich. Dabei müssen Symptome, die zu einer intensiven Symptomerfahrung führen, zunächst identifiziert und verstanden werden. Auf dieser Basis können Interventionen entwickelt und evaluiert werden
Spinal intramedullary schwannomas—report of a case and extensive review of the literature
Authors: Swiatek V. M. , Stein K.-P. , Cukaz H. B. , Rashidi A. , Skalej M. , Mawrin C. , Sandalcioglu I. E. , Neyazi B. 
Published: September 2020

AbstractIntramedullary schwannomas (IMS) represent exceptional rare pathologies. They commonly present as solitary lesions; only five cases of multiple IMS have been described so far. Here, we report the sixth case of a woman with multiple IMS. Additionally, we performed the first complete systematic review of the literature for all cases reporting IMS. We performed a systematic review of the literature in PubMed, EMBASE and Cochrane Central Register of Controlled (CENTRAL) to retrieve all relevant studies and case reports on IMS. In a second step, we analysed all reported studies with respect to additional cases, which were not identified through the database search. Studies published in other languages than English were included. One hundred nineteen studies including 165 reported cases were included. In only five cases, the patients harboured more than one IMS. Gender ratio showed a ratio of nearly 3:2 (male:female); mean age of disease presentation was 40.2 years; 11 patients suffered from neurofibromatosis (NF) type 1 or 2 (6.6%). IMS are rare. Our first systematic review on this pathology revealed 166 cases, including the here reported case of multiple IMS. Our review offers a basis for further investigation on this disease.
Carbon fiber–reinforced PEEK versus titanium implants: an in vitro comparison of susceptibility artifacts in CT and MR imaging
Authors: Krätzig Theresa , Mende Klaus C. , Mohme Malte , Kniep Helge , Dreimann Marc , Stangenberg Martin , Westphal Manfred , Gauer Tobias , Eicker Sven O. 
Published: September 2020

AbstractArtifacts in computed tomography (CT) and magnetic resonance imaging (MRI) due to titanium implants in spine surgery are known to cause difficulties in follow-up imaging, radiation planning, and precise dose delivery in patients with spinal tumors. Carbon fiber–reinforced polyetheretherketon (CFRP) implants aim to reduce these artifacts. Our aim was to analyze susceptibility artifacts of these implants using a standardized in vitro model. Titanium and CFRP screw-rod phantoms were embedded in 3% agarose gel. Phantoms were scanned with Siemens Somatom AS Open and 3.0-T Siemens Skyra scanners. Regions of interest (ROIs) were plotted and analyzed for CT and MRI at clinically relevant localizations. CT voxel–based imaging analysis showed a significant difference of artifact intensity and central overlay between titanium and CFRP phantoms. For the virtual regions of the spinal canal, titanium implants (ti) presented − 30.7 HU vs. 33.4 HU mean for CFRP (p < 0.001), at the posterior margin of the vertebral body 68.9 HU (ti) vs. 59.8 HU (CFRP) (p < 0.001) and at the anterior part of the vertebral body 201.2 HU (ti) vs. 70.4 HU (CFRP) (p < 0.001), respectively. MRI data was only visually interpreted due to the low sample size and lack of an objective measuring system as Hounsfield units in CT. CT imaging of the phantom with typical implant configuration for thoracic stabilization could demonstrate a significant artifact reduction in CFRP implants compared with titanium implants for evaluation of index structures. Radiolucency with less artifacts provides a better interpretation of follow-up imaging, radiation planning, and more precise dose delivery.
Competition Among Mental Health Organizations: Environmental Drivers and Strategic Responses
Authors: Bunger Alicia C. , Choi Mi Sun , MacDowell Hannah , Gregoire Thomas 
Published: September 2020

AbstractWhile mental health system reforms have sought to leverage competition in the private sector to improve service quality and costs, competition among mental health organizations is poorly understood. To inform future studies about the impact of policy and system reforms on mental health organizations and service delivery, this qualitative study explores (1) resources for which organizations compete most intensively, (2) drivers of competition, and (3) leaders’ strategic organizational responses. Semi-structured phone interviews were conducted with 15 organizational leaders (CEO’s, executive directors) representing about 22% of organizations in the regional mental health market. Interviews covered leaders’ perceptions about competition, and their strategic responses. Porter’s seminal framework on competition was used to interpret codes and themes. Intensive competition for personnel was driven by workforce shortages, new for-profit organizations, and alternative employment opportunities. In response, organizations have attended to wages/benefits, recruitment, and retention. However, strong community need, expanded insurance coverage, and a history of local strategic responses that created service niches appeared to have minimized competition for financial resources in the region. Competition for funding and clients was expected to intensify under systems reform, and in anticipation, organizations were expanding services. Leaders also feared for the viability of smaller organizations in highly competitive environments. Consistent with theory on competition, mental health organizations compete and respond in ways that might improve services. However, the goals of privatization may have been unrealized because of minimal competition for funding and clients, and intense competition may undermine quality.
Basel Compliance and Financial Stability: Evidence from Islamic Banks
Authors: Bitar Mohammad , Naceur Sami Ben , Ayadi Rym , Walker Thomas 
Published: September 2020

AbstractWe find that compliance with the Basel Core Principles (BCPs) has a strong positive effect on the stability of conventional banks, and a positive but less pronounced effect on the stability of Islamic banks. We also find that the main impact of compliance is an increase in capital ratios, whereas other components of the Z-score are negatively affected. This reflects the desire of banks to be more closely integrated into the global financial system by holding higher capital ratios. The findings also justify the 2015 decision of the Islamic Financial Services Board to publish similar principles for Islamic banks.
Alzheimer’s disease: natural products as inhibitors of neuroinflammation
Authors: Olajide Olumayokun A. , Sarker Satyajit D. 
Published: September 2020

AbstractAlzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.
Specific Disease Knowledge as Predictor of Susceptibility to Availability Bias in Diagnostic Reasoning: a Randomized Controlled Experiment
Authors: Mamede Sílvia , Goeijenbier Marco , Schuit Stephanie C. E. , de Carvalho Filho Marco Antonio , Staal Justine , Zwaan Laura , Schmidt Henk G. 
Published: September 2020

Abstract
Background
Bias in reasoning rather than knowledge gaps has been identified as the origin of most diagnostic errors. However, the role of knowledge in counteracting bias is unclear.

Objective
To examine whether knowledge of discriminating features (findings that discriminate between look-alike diseases) predicts susceptibility to bias.

Design
Three-phase randomized experiment. Phase 1 (bias-inducing): Participants were exposed to a set of clinical cases (either hepatitis-IBD or AMI-encephalopathy). Phase 2 (diagnosis): All participants diagnosed the same cases; 4 resembled hepatitis-IBD, 4 AMI-encephalopathy (but all with different diagnoses). Availability bias was expected in the 4 cases similar to those encountered in phase 1. Phase 3 (knowledge evaluation): For each disease, participants decided (max. 2 s) which of 24 findings was associated with the disease. Accuracy of decisions on discriminating features, taken as a measure of knowledge, was expected to predict susceptibility to bias.

Participants
Internal medicine residents at Erasmus MC, Netherlands.

Main Measures
The frequency with which higher-knowledge and lower-knowledge physicians gave biased diagnoses based on phase 1 exposure (range 0–4). Time to diagnose was also measured.

Key Results
Sixty-two physicians participated. Higher-knowledge physicians yielded to availability bias less often than lower-knowledge physicians (0.35 vs 0.97; p = 0.001; difference, 0.62 [95% CI, 0.28–0.95]). Whereas lower-knowledge physicians tended to make more of these errors on subjected-to-bias than on not-subjected-to-bias cases (p = 0.06; difference, 0.35 [CI, − 0.02–0.73]), higher-knowledge physicians resisted the bias (p = 0.28). Both groups spent more time to diagnose subjected-to-bias than not-subjected-to-bias cases (p = 0.04), without differences between groups.

Conclusions
Knowledge of features that discriminate between look-alike diseases reduced susceptibility to bias in a simulated setting. Reflecting further may be required to overcome bias, but succeeding depends on having the appropriate knowledge. Future research should examine whether the findings apply to real practice and to more experienced physicians.