bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Cost Of Illness Drug Reaction With Eosinophilia Systemic Symptoms Di RSUP Dr.Sardjito Yogyakarta
Authors: Halid Vicryanto , Perwitasari Dyah Aryani , Febriana Sri Awalia 
Published: March 2020

ABSTRAK Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) adalah reaksi alergi kulit dengan demam, kenaikan eosinofil darah dan komplikasi organ. Sulitnya diagnosa dan lama terapi serta berpotensi kekambuhan membuat DRESS menjadi masalah karena mempengaruhi ekonomi. Cost of illness (COI) merupakan analisis menentukan beban ekonomi penyakit yang terdiri dari beberapa perspektif. Penelitian ini bertujuan mengetahui total COI dari perspektif Rumah sakit berdasarkan jenis DRESS, jenis obat, dan jumlah obat penyebab DRESS. Penelitian non-experimental dengan desain cross-sectional retrospektif. Subyek penelitian 21 pasien. Parameter biaya komponen biaya medis langsung yaitu biaya instalasi gawat darurat, pengobatan, monitoring, penunjang dan rawat jalan. Hasil analisis data berupa median (range). Median total COI DRESS dengan komplikasi organ adalah Rp.13.194.963 dan Rp.10.123.495 untuk pasien DRESS tanpa komplikasi organ. Antibiotik menjadi obat penyebab DRESS terbanyak (55,55%) dengan range total biaya tertingginya Rp.53.576.350. Kesimpulan: Total COI DRESS di RSUP Dr.Sardjito tahun 2014-2018 satu pasien adalah Rp.13.546.700.Kata Kunci: Drug Reaction with Eosinophilia and Systemic Symptom, Cost OF illness, biaya medis langsung, komplikasi organ, perspektif Rumah sakit. ABSTRACT Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) are allergic skin reactions with fever, elevated blood eosinophils and organ complications. Difficult diagnosis and duration of therapy and potential recurrence make DRESS a problem because it affects the economy. Cost of illness (COI) is an analysis determining the economic burden of a disease consisting of several perspectives. This study aims to determine the total COI from the perspective of the hospital based on the type of DRESS, the amount and type of causative drug of DRESS. Non-experimental research with a retrospective cross-sectional design. Study subjects 21 patients. The cost parameters of the direct medical component costs are the costs of the emergency department, treatment, monitoring, support and outpatient care. The results of data analysis are in the form of a median (range). Results: The total median of COI DRESS with organ complications was Rp.13,194,963 and Rp.10,123,495 for DRESS patients without organ complications. Antibiotics became the most common drug causing DRESS (55.55%) with the highest total cost range of Rp.53,576,350. Conclusion: Total COI DRESS at Dr.Sardjito General Hospital in 2014-2018 one patient was Rp.13,546,700. Keywords: Drug Reaction with Eosinophilia and Systemic Symptom, Cost of Illness, direct medical costs, organ complications, perspective of the hospital.
Karakteristik Fisika Sediaan Suspensi Ekstrak Etanol Daun Gaharu (Aquilaria microcarpa Baill.) dengan Variasi Carboxymethyl Cellulose Sodium (CMC-Na)
Authors: Fitriana Mia , Halwany Wawan , Anwar Khoerul , Triyasmono Liling , Rahmanto Beny , Andriani Susy , Ainah Nur 
Published: March 2020

ABSTRAK Gaharu (Aquilaria microcarpa Baill.) merupakan salah satu hasil hutan yang memiliki aktivitas antioksidan. Ekstrak etanol daun A. microcarpa terbukti memiliki aktivitas antioksidan yang tergolong sangat aktif. Ekstrak etanol daun A. microcarpa kemudian dibuat menjadi sediaan suspensi dengan variasi CMC-Na sebagai agen pengsuspensi. Penelitian ini bertujuan untuk menentukan pengaruh konsentrasi CMC-Na terhadap karakteristik fisik suspensi ekstrak etanol daun A.microcarpa. Suspensi dibuat dengan variasi CMC-Na pada F1 (0,5% CMC-Na), F2 (1% CMC-Na) dan F3 (1,5% CMC-Na). Evaluasi sediaan suspensi meliputi organoleptis, uji viskositas, uji pH, uji homogenitas serta uji berat jenis suspensi. Nilai evaluasi suspensi dianalisis secara statistik dengan software SPSS 21. Hasil evaluasi fisik menunjukkan bahwa penambahan konsentrasi CMC-Na akan meningkatkan nilai viskositas dan berat jenis sediaan. Kesimpulan dari pengujian ini adalah variasi konsentrasi CMC-Na mempengaruhi hasil viskositas, serta berat jenis suspensi (p<0,05) dan tidak mempengaruhi hasil organoleptis, homogenitas dan pH suspensi. Kata kunci: Gaharu, suspensi, CMC-Na ABSTRACT Gaharu (Aquilaria microcarpa Baill.) is one of the Borneo’s forest products that has antioxidant activity. Ethanol extract of A. microcarpa folium has been shown to have antioxidant activity that is classified as very active. The ethanol extract of A. microcarpa folium was then made into a suspension preparation with variations of sodium CMC as a suspending agent. This study aimed to determine the effect of sodium CMC concentration on the physical characteristics of the ethanol extract of A.microcarpa folium. Suspension was made with variations of sodium CMC in F1 (0.5% sodium CMC), F2 (1% sodium CMC) and F3 (1.5% sodium CMC). Evaluation of suspension preparations included organoleptic, viscosity test, pH test, homogeneity test and suspension specific gravity test. The suspension evaluation data were analyzed statistically with SPSS 21 Software. The physical evaluation results showed that the addition of sodium CMC concentration would increase the viscosity and specific gravity of the preparation. The conclusion of this test was that variations in the concentration of sodium CMC affected the results of viscosity and suspension specific gravity (p <0.05) and did not affect the organoleptic yield, homogeneity and pH of the suspension. Keywords: Gaharu, suspension,
NEW APPROACH TO BUILDING A COMPETENCY MODEL FOR LIBRARY PROFESSIONALS
Authors: Makeeva O. V. 
Published: March 2020

The purpose of the article is to present a new approach to building a competency model for a specialist in library and information activities. Methods used in the work: analysis and generalization of the content of domestic and foreign sources on the problem of professional education.The article presents an analysis of the lists of competencies of the Federal State Educational Standard, opinions of specialists in the field of library and information activities, an approximate list of the scientific (academic) library specialist’s competencies, prepared in 2017 by employees of SPSL SB RAS at the request of the St. Petersburg State Institute of Culture representatives.It is concluded that, taking into account numerous discussions about FSES and the professional standard of a specialist in library and information activities, it is necessary to combine the efforts of representatives of the professional community for to achieve consensus in this area and update the existing regulatory framework. It is also advisable to consider the possibility of creating competency profiles that would form the basis for the above-mentioned documents and ensure interests of organizations providing training in the field of library and information activities and institutions-employers.Novelty. Complex approach is proposed to build a competency model for a specialist in library and information activities, based on integration of approved regulatory documents and employers’ requests: for each group of competencies the basic minimum should be determined (approved by the federal authorities responsible for the state supervision and ensuring compliance of requirements in composition of labor functions, knowledge and skills in approved documents) and the variable part, ensuring compliance of competencies being formed with particularities of libraries of various types (public, academic, special).This requires development of a regulatory framework in the field of library and information activities (updating existing and developing new documents). The proposed competency model correlates with regulatory documents.Practical significance: a competency model is proposed, within which educational organizations, institutions of the library and information sphere can jointly form an effective process for training specialists.
Popliteal Cysts
Authors: Van Nest Duncan S. , Tjoumakaris Fotios P. , Smith Bradley J. , Beatty Tricia M. , Freedman Kevin B. 
Published: March 2020

Background:
Treatment methods for popliteal cysts have varied over the past several decades and have posed challenges to providers as recurrences were frequent. With greater understanding of relevant anatomy, both operative and nonoperative treatment methods have evolved to appropriately target relevant pathology and improve outcomes. The purposes of this review were to outline the evolution of treatment methods and to qualitatively summarize clinical outcomes.

Methods:
We performed a systematic review on treatments for popliteal cysts to include publications from 1970 to 2019. Other inclusion criteria consisted of studies with ≥10 patients enrolled, studies with a patient age of ≥16 years, studies with an adequate description of the treatment technique, and studies with a Level of Evidence of IV or higher. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and literature quality was assessed using a modified Coleman methodology score.

Results:
Thirty studies met inclusion criteria in this review. Nine studies discussed nonoperative treatment, and 21 studies discussed operative treatment. Eight of the 9 nonoperative treatment studies utilized corticosteroid injections. The most recent studies have advocated for ultrasound-guided intracystic injection with possible cyst fenestration. Most operative studies utilized an arthroscopic approach to enlarge the communication with the joint space. However, alternative treatment techniques are still utilized.

Conclusions:
The current literature on the treatment of popliteal cysts indicates that intracystic corticosteroid injection with cyst fenestration is an effective nonoperative treatment method. Arthroscopic surgical procedures with enlargement of the communication have been most widely studied, with positive results; however, further studies are needed to confirm superiority over other treatment methods.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Hydraulic Fracturing Modeling, Fracture Network, and Microseismic Monitoring
Authors: Urban-Rascon Edgar , Aguilera Roberto 
Published: March 2020

Abstract
This paper introduces a 3D hydraulic fracturing propagation model (3D-HFPM) for evaluating fracture extension, geometry, stress response, fracture spacing, and potential for refracturing. The model is illustrated with data of the Horn River shale of Canada.
The model is developed using a combination of finite element method (FEM) and boundary element method (BEM) for evaluating fluid-flow, fracture deformation, and stress change in the reservoir. The model is calibrated using a limited amount of microseismic observations and recreate the fracture network when microseismic data are unavailable.
An adapting meshing algorithm is incorporated to improve the capacity of the model to handle large and complex fracture networks such as the ones found in low permeability reservoirs.
The continuity of fracture propagation and fluid leak-off during stimulation may be high enough to connect different production intervals and to create interference between stages, especially in wells with small path fracture spacing and multi-level completions.
The comparison between the propagation model and microseismic data shows good agreement as the number of events increases as the fracture propagates into the reservoir. However, using only microseismic data to calculate the extension of the hydraulic fracture results in an overestimation of the fracture length.
The model quantifies the altered stress zone, which is helpful to determine possible fracture reorientation and spacing. The evaluation of stress shadow and fracture reorientation reveals the advantages of refracturing using new over old perforations. The operation restores fracture conductivity and increases the fracture network as well as the drainage areas leading to an economic operation.
The model improves the characterization of the Stimulated Reservoir Volume (SRV) in tight and shale reservoirs in those cases where microseismic data are scarce. Furthermore, the model is a viable tool for evaluating potential refracturing candidates.
An Integrated Field and Simulation Study to Understand the Role of Shut-in on a Montney Well Performance
Authors: Soleiman Asl Taregh , Moussa Tamer , Ezulike Obinna , Dehghanpour Hassan 
Published: March 2020

Abstract
In this paper, we analyze and simulate the production data before and after an extended shut-in period from a horizontal well completed in the Montney Formation. After flowback and early post-flowback production, the well was shut-in for 7 months due to facility completion. When the well was reopened, the hydrocarbon production rates increased significantly compared to the values before the shut-in. To investigate the reasons behind this enhancement, we simulated three-phase production rates and bottom-hole pressure using the actual reservoir geological model.
To match the production data before the shut-in period, we had to account for the reduction in oil and gas relative permeabilities due to water blockage. This was done by using multipliers of interblock fluid-flow transmissibility near the matrix-fracture interface. We used these transmissibility multipliers as matching parameters, to achieve the match between measured and simulated production data. However, the best history match was achieved, when the values of transmissibility multipliers are increased by 6.5 times after the shut-in. This suggests a significant increase in oil and gas relative permeabilities due to reduction in water blockage near fracture-matrix interface during the extended shut-in period. Since the simulation model was not able to capture the imbibition process controlled by different driving forces, we used transmissibility multipliers to mimic this phenomenon and its corresponding effects on production rates. In addition, we performed sensitivity analyses to investigate the effects of shut-in on the well productivity and economic profitability in terms of net present value (NPV). The results show that for this well, a 6-month shut-in period is optimal for maximizing NPV and hydrocarbon production.
Chemical Proppant Generated in the Fracture from the Novel Fracturing Fluid System
Authors: Luo Zhifeng , Zhang Nanlin , Zhao Liqiang , Wu Lin , Pei Yuxin , Miao Weijie , Yu Yang 
Published: March 2020

Abstract
Hydraulic fracturing is an important method to improve the oil and gas production in low and ultra-low permeability reservoirs. A remarkable progress has been made in the technology and materials. However, the existing conventional hydraulic fracturing technology faces problems, such as reservoir damage, equipment abrasion, low effective propped area, and early screen-out. Therefore, a novel self-propped fracturing fluid (SPFF) was proposed, which remains in the liquid-phase before entering the fracture, and forms solid proppant particles when stimulated by the reservoir temperature after entering the fracture (Chemical proppant, CP).
In this paper, the micro-morphology of CP was studied by SEM, and the temperature of the CP-formed was measured by the CP formation experiments at room temperature and field conditions. Furthermore, the compressive strength, thermal stability, stability in formation fluid, acid and alkali, leak-off, core damage, and fracture conductivity of the developed SPFF were tested.
The test results show that the leak-off volume and core damage level of SPFF were less than that of conventional fracturing fluid, thereby effectively reducing the damage to the reservoir permeability. The CP exhibited good performance in terms of compressive strength, thermal stability, stability in reservoir fluid and treatment fluid. Besides, the conductivity of the propped fracture was high. These advantages determine that CP can meet the field treatment requirements. The CP could enter any narrow fractures, and effectively solved the existing problems in the conventional fracturing technology by significantly improving the fracturing effect, especially the network fracturing effect in tight reservoir systems.
A Case of Hypokalemia-induced Bidirectional Ventricular Tachycardia
Authors: Xie Yanan , Han Jingzhe , Liu Jinming , Hao Jie , Zu Xiuguang , Hao Yuming 
Published: March 2020

Abstract
Background: Bidirectional ventricular tachycardia (BVT) is a rare but serious arrhythmia. Hypokalemia is commonly seen in clinical practice, but hypokalemia-induced BVT has rarely been reported. Case presentation: A 74-year-old male patient with the symptom of chest distress and palpitation was admitted due to frequent discharge of ICD for 4 days. Before admission, the patient experienced diarrhea after intake of crabs, and felt frequent discharge of ICD with a total of about 17 discharges in 4 days. He had no history of digitalis use. Serum potassium after admission was 3.1 mmol/L and the ECG was consistent with BVT. The diagnosis was ventricular tachycardia, electrical storm and hypokalemia, and ventricular tachycardia was completely relieved after the correction of hypokalemia. Conclusions: After correction of hypokalemia in this patient, the episode of BVT was terminated and no recurrence of BVT was noted during long-term follow-ups, confirming the diagnosis of hypokalemia-induced BVT.
A study on linking of clinical phenotype and gene expression profile in systemic lupus erythematosus
Authors: Ciou Jian-Ruei , Ho Pu-Wei , Wu Po-Chang , Chen Shu-I , Chang Ching-Mao , Chang Hen-Hong , Chu Hsueh-Ting 
Published: March 2020

Abstract
Objectives: Malar rash is one of clinical phenotypes seen in systemic lupus erythematosus (SLE). However, the pathogenesis of malar rash is not clear for each case of SLE patients. In this paper we endeavored to investigate the linking of clinical phenotype from the gene expression profiles between both patients with malar rash and without malar rash. Therefore we might perform better evaluation of the possible prognosis for different SLE patients in the future.Methods: This study utilizes transcriptome sequencing (RNA-Seq) technologies to discover underlying gene expression profile for systemic lupus erythematosus patients. We performed transcriptome sequencing experiments and analyzed differentially expressed genes (DEGs) and associated pathways.Results: From the analysis of gene expression profiling, we identified the gene DAAM2 is the most differentially expressed gene for patients with malar rash. Using a gene set enrichment analysis, we discuss the linkage between DAAM2 and the possible pathways for systemic lupus erythematosus with malar rash. Conclusions: We identified DAAM2 as a candidate biomarker for the clinical phenotype of malar rash for systemic lupus erythematosus.
“MicroRNA expression profiling of human milk derived exosomes identifies miR-630 and miR-378g as biomarkers in HIV-1 infected women”
Authors: Zahoor Muhammad Atif , Yao Xiao-Dan , Henrick Bethany M , Verschoor Chris P , Abimiku Alash'le , Osawe Sophia , Rosenthal Kenneth L 
Published: March 2020

Abstract
Background: Despite the use of antiretroviral therapy (ART) in HIV-1 infected mothers approximately 5% of new HIV-1 infections still occur in breastfed infants annually which warrant for the development of new additional strategies to completely prevent new HIV-1 infections in infants. Human Milk (HM) exosomes are highly enriched in maternal microRNAs (miRNAs) which after ingestion and absorption play an important role in neonatal immunity. Although, HM exosomes from healthy donors are known to inhibit HIV-1 transmission; the effect of HIV-1 on HM exosomal miRNA signatures remains unknown. In the present study, HM derived exosomal miRNA profiles were investigated in HIV-1 infected lactating women. Methods: First week postpartum HM exosomes were purified from uninfected control and HIV-1 infected mothers (n=36), processed for RNA extraction and subjected to miRNA expression profiling by NanoString technology. The data were analyzed, and targets were predicted. Results: We describe that HIV-1 perturbed the differential expression pattern of 19 miRNAs (13 up and 6 downregulated) in HIV-1 infected women compared to healthy controls. DIANA-miR functional Pathway analyses revealed that multiple biological pathways are involved including Cell cycle, Pathways in Cancer, TGF-β signaling, FoxO signaling, Fatty Acid Biosynthesis, p53 signaling and Apoptosis. Further, the receiver operating characteristics (ROC) curve analyses of two of the identified miRNAs, miR-630 and miR-378g for separating HIV-1 infected women from healthy controls yielded areas under the ROC curves of 0.82 (95% CI= 0.67 to 0.82) and 0.83 (95% CI= 0.67 to 0.83), respectively highlighting their potential to serve as biomarkers of HIV-1 infection in women. Conclusions: Our studies provide new information that HIV-1 perturbs the expression levels of HM derived exosomal miRNAs in lactating women. The stability of HM exosomes at room temperature raises the possibility of their utility in HIV-1 screening prior to HIV-1 specific testing in countries like Nigeria. Further, our data may also contribute to the development of new therapeutic strategies in prevention of mother-to-child transmission (MTCT) of HIV-1 in infants.
Relations between influenza, dengue outbreaks, and subsequent bacterial sepsis in French Guiana: a time series analysis
Authors: Cropet Claire , Abboud Philippe , Mosnier Emilie , Epelboin Loïc , Djossou Félix , Schrooten Ward , Sobesky Milko , nacher mathieu 
Published: March 2020

Abstract
Objective : Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked and this may not be the case. Dengue is often followed by prolonged asthenia and some physicians hypothesized increased susceptibility to infections based on anecdotal observations. Time series of influenza and dengue surveillance were confronted with bacterial sepsis admissions to test the hypotheses. Monthly surveillance data on influenza and dengue and aggregated sepsis data in Cayenne hospital were matched between 24/10/2007 and 27/09/2016. An ARIMA (1,0,1) model was used. Results : The series of the number of monthly cases of sepsis was positively associated with the monthly number of cases of influenza at time t (β=0.001, p=0.0359). Forecasts were imperfectly correlated with sepsis since influenza is not the only risk factor for sepsis. None of the ARIMA models showed a significant link between the dengue series and the sepsis series. There was thus no link between dengue epidemics and sepsis but it was estimated that for every 1000 cases of flu there was one additional case of sepsis. In this tropical setting, influenza was highly seasonal, and improved vaccination coverage could have benefits on sepsis.