bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapy of Dry Eye Syndrome after Inflammatory Diseases of Cornea
Authors: Gndoyan I. A. , Petrayevsky A. V. 
Published: April 2020

Purpose: evaluation of the efficacy of the drug Tealose® in the therapy of cornea inflammatory diseases consequences such as dry eye syndrome.Patients and methods: 34 patients (34 eyes) with dry eye syndrome after inflammatory diseases of the cornea, aged 28–56 years old were included in the study. Two clinical groups were formed: observation group — 20 subjects (20 eye) and comparison group — 14 subjects (14 eyes). The dynamics of such indicators were estimated under therapy: visual acuity with maximal correction, corneal epithelium entity according fluoresceine dye test, tear production according Schirmer and Norn tests, the grade of dry eye syndrome severity according index of OSDI — Questionnarie. The patients in observation group in addition to the basic therapy, which included instillation antiseptics и 4 % taurine solution, were treated with 3 % solution of tregalose (Tealose®, “Laboratuar Thea”, France) by such mode: using of 4 times daily instillations during 1 month, 1 month break, than continuation of the same regimen instillations during 1 month was performed. The patients in comparison group in addition to the same basic therapy were treated with Visomitin® (“Mitotech”, Russia) by the mode, which was used for tregalose.Results. The improvement of cornea’s epithelization (p < 0,05), increasing of visual acuity with maximal correction (p < 0,05), improvement of tear production (p < 0,05), as well as the OSDI-index (p < 0,05) were revealed in the patients of the observation group. In the patients of the comparison group positive dynamics of these indicators was insignificant and unreliable.Conclusions. Using of 3 % tregalose solution in patients with consequences of inflammatory diseases of the cornea — keratitis leads to effective treatment of “dry eye” syndrome, reduces the severity of epithelization disorders and tendency to scarring in the corneal tissue.
Model of Two‐Years Forecasting of the Anti‐Existent Patients With Acute Decompensation of Heart Failure on the Background of the Intermediate Fraction of Left Ventricle
Authors: Skorodumova E. G. , Kostenko V. A. , Skorodumova E. A. , Siverina A. V. , Shulenin K. S. , Rysev A. V. 
Published: April 2020

Objective. Build a prognostic model using clinical, laboratory, and instrumental data to predict mortality in patients with midrange left ventricular ejection fraction (mrLVEF) within two years after hospitalization for acute decompensated heart failure (ADHF).Materials and Methods.The study included 121 patients hospitalized for ADHF with mrLVEF ranging from 40% to 49.9% (91 males and 30 females, mean age 64.6±14.8 years). The independent sample used to validate the statistical model included 71 patients with ADHF and mrLVEF with a mean age of 65.59±12.12 years. Sex distribution of the independent sample was 51 males (70.8% of the independent sample), 20 females (27.8% of the total independent sample). In-hospital mortality of patients included in the study was 4.2%, and long-term mortality was 36.8%. We developed a tool to assess the risk of two-year mortality using classification trees.Results.The root node is the red blood cell distribution width–coefficient of variation (RDW-CV); its diagnostic value in this model was 13.3%. The second-level nodes are glomerular filtration rate (GFR), with a cutoff level of 35 mL/min/1.73 m2, and chronic kidney disease (CKD). The third-level nodes are sex, the anterior-posterior dimension of the left atrium, with the cutoff level >47 mm, and low red blood cell count <4.22x1012/L. The estimated sensitivity of the model is 71.4%; estimated specificity is 85.7%.Conclusion.This model can be used to assess long-term mortality risk and identify groups of patients with mrLVEF who require closer monitoring.
Internet Addiction in the Students of Semnan University of Medical Sciences
Authors: Pakdel Abbas , Yousefi Sedighe , Razaviyan Javad , Eslami Mohammad Javad , Hadavi Razie 
Published: April 2020

Introduction: The ever-increasing advancements on the World Wide Web and the countless increase in its users, especially among the university students, caused many problems. The internet addiction in the students is one of the significant problems which can have adverse effect on their health as well as their academic performance. Therefore, we intended to study the internet addiction among the students of the Semnan University of Medical Sciences.Methods: 260 students of the Semnan University of Medical Sciences were randomly sampled and entered into this descriptive-analytical study. The Young's standard questionnaire was used to collect the data and its reliability and validity were confirmed. We have used SPSS 18.0 software to analyze the data. The significance level was considered 5% (p-value).Findings: The analysis of the results showed that the internet addiction among the students participating in the study was as follows: 6% without internet addiction, 68% mild internet addiction and 31.6% moderate internet addiction. The internet addiction in the male students has been significantly higher than the female ones. The results analysis has also indicated that there is a significant and direct relationship between the hours of internet use and the extent of the addiction.Conclusions: Regarding the fact that most of the students in the present study have shown mild internet addiction; then we can hope with a proper planning which will provide the conditions, the students will use the internet more in research and science fields and thus wasting their precious time will be avoided.
Determine the impact of the implementation of the program checklists resulting from official inspections in identifying hazards in an automotive industry
Authors: Halvani GH , Sahraee M 
Published: April 2020

Introduction: Nowdays, the main concern of the responsible organizations in the field of safety is identifying and eliminating the dangers that threaten people`s lives and it can cause damage. Perhaps it can be said with caution that today there are so many incidents in the industrialized countries. A common approach to safety analysis and accident prevention is inspection. The purpose of this study is determining the impact of the implementation of the schedule of checklist resulting from official inspections in identifying hazards in an automotive industry.
Methods:The library and scrolling method was used to collect data. In the theoretical sections, a questionnaire was developed using a library method and a scrolling method was used to collect data. In this research, descriptive and inferential statistics were used to analyze the information. The samples were reviewed along with numerous charts. And the data were entered into the stata software for analysis.
Results: In this study, 716 items are marked with a check list, 459 (0.64%) risk befor and 579 (0.81%) the risk was detected after a checklist. There was a significant difference between the two ratios. In other words, the implementation of the checklist is effective in identifying the dangers.
Conclusion: Regarding the fact that in the case study company, the checklist did not play a major role in hazard identification and was not included in the checklist. It`s better to take advantage of checklist. Based on the results of these studes, it can be concluded that checklist inspections can have a significant impact on the identification of hazards.
Production of non-timber forest products (NTFPs) and diversity of harvesting practices and decision-making processes in northern Thailand’s community forests
Authors: Wimolsakcharoen Wuthiwong , Dumrongrojwatthana Pongchai , Trébuil Guy 
Published: April 2020

Previous research on community forestry in Thailand has mainly focused on its institutional dimensions. Comprehensive knowledge on the production of non-timber forest products and on harvesting practices and decision-making processes is therefore still limited, particularly in relation to community-based forestry. A survey was performed to estimate the production of non-timber forest products and to characterise the diversity of harvesting practices and decision-making processes in northern Thailand’s community forests. Field investigations were conducted once a month for 12 months in seven community forests in the Lainan sub-district in Nan Province, using a grid-based sampling technique. Production and productivity of the main non-timber forest products were calculated by total fresh weight. In-depth interviews were conducted individually with 231 local harvesters to understand their NTFP harvesting practices and decision-making processes. Young shoots of Melientha suavis, queen broods of Oecophylla smaragdina and edible mushrooms were found to be the three main non-timber forest products collected, with productivity of 2, 12, and 2 kg/ha/year, respectively. Harvesting practices were characterised as applied by (A) landless villagers, (B) small- and medium-sized landholders, (C) larger landholders, and (D) outsiders. Local harvesters displayed different decision-making processes in resource harvesting depending on periods of resource availability, the duration of harvests and the quantities harvested. These quantitative data on resource productivity together with knowledge of harvesting practices and decision-making processes among harvesters will provide input to a participatory resource management process to support exchanges of knowledge among local stakeholders and explore scenarios for appropriate rules of access so as to improve the sustainability of non-timber forest product harvesting.
Diseño de interfaz de apoyo para la elaboración de programas de módulos de aprendizaje universitarios
Authors: Trevera-Dávila Acela , Trevera Dávila Carlos 
Published: April 2020

Rev.esc.adm.neg
Con el avance y la necesaria implementación de la tecnología, surgen para los centros educativos nuevos retos. Sin duda, los más importantes, en cuanto al aprovechamiento de las tecnologías para la optimización de los procesos, implican identificar los equipos y las herramientas que se adapten a sus requerimientos o necesidades; explorar las posibilidades para la gestión y agilización de los procesos y hacer un uso racional y planificado de estos. Por esta razón, el objetivo del presente trabajo es la revisión de un caso de aplicación de las tecnologías de la información y la comunicación —TIC— en el área administrativa de una institución de educación superior, por medio de un sistema de gestión orientado a la estructuración de los programas académicos. Se utilizó como estrategia metodológica la investigación descriptiva y exploratoria, de modo que se identificaron las áreas de mayor problemática para los docentes y se generaron alternativas de solución. Así pues, se concluyó que la automatización de los procesos de planeación docente representa un área de oportunidad para la mejora en la gestión administrativa, en la medida en que disminuye tiempos de entrega y mejora el desempeño docente, y mantiene no solo actualizado al personal en el uso de TIC, sino también los procesos de la institución.
Twelve-Month Prevalence of Psychiatric Morbidity in Cancer Patients in a Nigerian Oncology Centre
Authors: Lasebikan Victor , Fakunle Shina , Lasebikan Tiwatayo , Alabi Morufat Abosede , Adenipekun Adeniyi 
Published: April 2020

Abstract
Background Cancer is a leading cause of mortality worldwide and is associated with a wide range of psychiatric morbidity.Methods In this descriptive study, 130 patients with different types of cancer were interviewed. Information on sociodemographic characteristics, medical comorbidity, stage of cancer, duration of treatment was obtained. Psychological distress was assessed using the GHQ-12, and psychosocial distress with the Distress Thermometer (DT). The MINI was used to establish the presence or absence of any psychiatric diagnosis, including any substance use disorder. Information on receipt of formal psychiatric treatment was also obtained. Associated factors and predictors of “Any Mental Disorder” (AMD) were determined. Analysis was carried out using SPSS 20.0 Results Prevalence of psychological distress (GHQ score > 2) was 63.8%, psychosocial distress (DT score > 3) (60.8%), adjustment disorder (20.0%), anxiety y disorder (18.5%), major depression (15.4%), delirium (6.9%), psychosis (2.3%), mania (0.8%), 12-month alcohol use disorder (3.8%), 12-month tobacco use disorder (0.8%), 12-month opioid use disorder (26.9%) and 12 month cannabis use disorder (0.8)%. In all, 66.9% had AMD. The most common medical comorbidity was hypertension (36.2%) and diabetes (23.1%). Predictors of AMD were: Predictors of AMD were: duration of cancer treatment above 6 months OR = 2.66, 95% CI (1.17-6.05), DT score > 3 OR = 2.78, 95% CI (1.24-6.21) and the presence of any medical comorbidity OR = 2.29, 95% CI (1.02-5.14).Conclusion Cancer is associated with significant psychiatric morbidity, necessitating a collaborative Consultation Liaison Psychiatric service in cancer care.
Barriers and Facilitators of Kangaroo Mother Care Adoption in Five Chinese Hospitals: a Qualitative Study
Authors: Yue Jieya , Liu Jun , Williams Sarah , Zhang Bo , Zhao Yingxi , Zhang Qiannan , Zhang Lin , Liu Xin , Wall Stephen , Wetzel Greta , Zhao Gengli , Bouey Jennifer 
Published: April 2020

Abstract
Background Kangaroo mother care (KMC) has been proved to be a safe and cost-effective intervention for preterm babies. Despite this evidence and global guidelines promoting KMC, it has not been widely adopted in China. In this study, we aim to assess barriers and facilitators of KMC adoption in neonatal intensive care units (NICUs) and postnatal wards in China. Methods We conducted clinical observation and semi-structured interviews in seven NICUs and postnatal wards housed in five hospitals from different provinces in China between August and September 2018. We conducted interviews with pediatricians, obstetricians, nurses and parents who performed KMC to understand their perspectives on barriers and facilitators of KMC implementation and sustainability. We further explored health system’s readiness and families’ willingness to adopt KMC following its introduction in pilot hospitals. We coded data for emerging themes related to perceived barriers and facilitators of KMC adoption, specifically those unique in the Chinese context and less commonly reported in previous systematic reviews from other countries. Results Five hospitals were included for clinical observation and 38 semi-structured interviews were conducted. Common cultural barriers included concerns with postpartum confinement (Zuo-yue-zi) and grandparents’ resistance, while strong family support enabled KMC adoption. Parents may feel anxious and guilty about having a preterm baby, this is a parental-level barrier to KMC. Hospital-level factors such as fear of nosocomial infection and shortage of staff and spaces impeded KMC implementation, and hospital-led supportive community and peer group contributed to KMC uptake. Financial barriers included lodging costs for caregivers and supply costs for hospitals. Conclusions Barriers and facilitators exist across cultural, hospital, parental and financial levels. While several factors were common in other study settings, there are also barriers and facilitators unique to Chinese context, e.g. concerns with postpartum confinement (Zuo-yue-zi), grandparents’ resistance and staff’s fear of nosocomial infection. We recommend interventions specificially targeting these barriers and facilitators including family and peer support for improved KMC adoption in China. We also recommend that specific barriers and challenges to KMC in particular settings be identified and be taken into account prior to KMC uptake in other settings.
Racial and ethnic patterns and differences in health care expenditures among Medicare beneficiaries with and without cognitive limitation or Alzheimer's disease and related dementias: a retrospective cohort study
Authors: Park Sungchul , Chen Jie 
Published: April 2020

Abstract
Background: Numerous studies have documented racial and ethnic differences in the prevalence and incidence of Alzheimer's disease and related dementias (ADRD). Less is known, however, about racial and ethnic differences in health care expenditures among older adults at risk for ADRD (cognitive limitation without ADRD) or with ADRD. In particular, there is limited evidence that racial and ethnic differences in health care expenditures change over the trajectory of ADRD or differ by types of service.Methods: We examined racial and ethnic patterns and differences in health care expenditures (total health care expenditures, out-of-pocket expenditures, and six service-specific expenditures) among Medicare beneficiaries without cognitive limitation, those with cognitive limitation without ADRD, and those with ADRD. Using the 1996-2017 Medical Expenditure Panel Survey, we performed multivariable regression models to estimate expenditure differences among racial and ethnic groups without cognitive limitation, those with cognitive limitation without ADRD and those with ADRD. Models accounted for survey weights and adjusted for various demographic, socioeconomic, and health characteristics.Results: Asians, and Latinos without cognitive limitation had lower total health care expenditures than whites without cognitive limitation ($10236, $9497, $9597, and $11541, respectively), but there were no racial and ethnic differences in total health care expenditures among those with cognitive limitation without ADRD and those with ADRD. In all populations, however, blacks, Asians, and Latinos tended to have lower out-of-pocket expenditures than whites (except for Asians with cognitive limitation without ADRD). Furthermore, service-specific health care expenditures varied by racial and ethnic groups.Conclusions: Our findings may suggest that racial and ethnic minority groups did not experience limited access to care before and after ADRD diagnosis. Differences in out-of-pocket expenditures and service-specific expenditures may be attributable to racial and ethnic differences in care access and/or care preference based on family structure and cultural/economic factors. Particularly, heterogeneous patterns of service-specific expenditures by racial and ethnic groups underscore the importance of future research in identifying determinants leading to variations in service-specific expenditures among racial and ethnic groups.
Chronic Kidney Disease and associated factors among HIV/AIDS Patients on HAART at University of Gondar Referral Hospital, Northwest Ethiopia
Authors: Manaye Gizachew Ayele , Abateneh Dejene Derseh , Asmare Wondwossen Niguse 
Published: April 2020

Abstract
Background In developing countries, both opportunistic infections and chronic diseases account a high HIV associated mortality and morbidity. Chronic kidney diseases (CKD) associated with HIV infection has got increased attention in sub-Saharan Africa as a result of the high HIV prevalence and due to the late diagnosis and initiation of HAART. Thus, this study was conducted to assess CKD and associated factors among HIV patients on HARRT in Northwest Ethiopia. Methods A hospital-based cross-sectional study with a secondary data review was conducted from February 01 to April 30, 2017, at the University of Gondar Referral Hospital, Northwest Ethiopia. The study participants were selected using a systematic random sampling technique. Socio-demographic and clinical data were collected using a semi-structured questionnaire by trained nurses. Venous blood and urine specimen was collected for serum creatinine and urine protein determination respectively. Glomerular filtration rate was estimated using the CKD–EPI estimator. Data were entered into SPSS version 20 for analysis. Bivariate and multivariate logistic regression was employed and p-value < 0.05 was considered statistically significant. Results A total of 336 HIV patients on HARRT participated in the study. The mean (SD) age of the participants was 39.7 ( + 9.7) years. The study participants were on HAART with an average of 7.5 ( + 3) years. Before ART initiation, the majority of patients had WHO clinical stage II and III, 251 (74.7%), CD4+T cell count < 200 cells/mm 3 , 221 (65.8%).The overall prevalence of CKD was 16.1%. About 27 (8.0%), 16 (4.8%), 11 (3.3%) of the participants had stage 1 and stage 2 CKD and chronic renal failure (stage 3a-5) respectively. With multivariate logistic regression analysis being male (AOR=2.05 (1.03-4.09), p=0.04, occupation merchant (AOR=2.91(1.00-8.48),p=0.049)and viral load > 1000 copies/mm 3 (AOR=3.1 (1.38-7.00), P<0.01) were significantly associated with CKD. Conclusions The prevalence of CKD among HIV patients on HARRT is high. Being male, merchant and viral load > 1000 copies/mm 3 were associated factors of CKD. Patients should be regularly monitored and screened for early diagnosis and management of CKD. Those patients with high viral load and male patients should be closely followed.
CircVAPA promotes proliferation and metastasis of retinoblastoma by modulating miR-615-3p and SMARCE1
Authors: Xu Qibin 
Published: April 2020

Abstract
Background Growing evidence reveals that circular RNAs (circRNAs) play roles in cancer development. However, the effects and possible mechanisms of circRNAs in retinoblastoma (RB) are far from clear. Methods circVAPA expression pattern was identified by RT-qPCR. CircVAPA induced effects on RB cells were tested by CCK-8, clone forming, flow cytometry and transwell assays. Bioinformatics assay, rescue experiments and dual luciferase tests were applied for mechanism exploration. Additionally, mouse models were established for in vivo assays. Results circVAPA was expressed at high levels in human RB specimen and RB cell lines, and was correlated with poor outcomes of Rb patients. Knockdown of circVAPA could suppress the malignant phenotype of RB. Mechanistic experiments demonstrated that miR-615-3p could reverse the circVAPA induced effects on RB cells, and the downstream oncogene SMARCE1 was positively regulated by circVAPA via miR-615-3p. Further, in vivo analysis confirmed the findings. Conclusions In summary, circVAPA promoted RB proliferation and metastasis by sponging miR-615-3p, thereby upregulating SMARCE1. CircVAPA is a potential biomarker of Rb therapy.