bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Need for Affect and Cognition Culture-Dependent? Implications for Global Public health Campaigns: A Cross-Sectional Study
Authors: Zhang Min , Zhu Bei , Yuan Chunlan , Chao Chao , Wang Jiaofeng , Ruan Qingwei , Bao Zhijun , Chen Jie , Arceneaux Kevin (Vin) , Wielen Ryan Vander , Siegle Greg Jeremy 
Published: October 2020

Abstract
Background: Cultural differences in affective and cognitive intrinsic motivations could introduce challenges to global public health campaigns, which use cognitive or affective goals to evoke desired attitudes and proactive health-promoting actions. This study aimed to demonstrate cross-cultural differences in affective and cognitive intrinsic motivations, and discuss the potential value of this information in public health promotion.Methods: A cross-sectional survey, using cross-culturally validated need for affect (NFA) and need for cognition (NFC) scales, was carried out among 1166 Chinese participants and compared to published data from 980 American participants. Additionally, we assessed a highly prevalent symbolic geriatric health condition, hearing loss, in 500 community-dwelling seniors. MANOVA test and Hedge’s g statistic were employed to compare the NFA and NFC levels between individuals from different countries and between seniors with and without hearing loss. The relation of early healthcare seeking intention to NFA and NFC was also explored.Results: The primary Chinese sample demonstrated decreased NFA and NFC in contrast to their American peers. This difference was preserved in the senior sample. Moreover, seniors with hearing loss had even lower NFA and NFC than those without hearing loss. Intention for early healthcare seeking was low but was associated with intrinsic motivation.Conclusions: There was a general lack of affective and cognitive intrinsic motivation in Chinese individuals, particularly in seniors with hearing loss, compared with their American peers. These differences, point to a potential challenge in framing effective messages for some cultures in the geriatric public health domain. Ideally, recognizing and understanding this challenge will inspire consideration of novel persuasive strategies for these audiences.
Hodgkin Lymphoma Management; A 20-year Retrospective Study
Authors: Ghazizadeh Farid , Noroozi Mehran , Hejazi Sasan , Sedokani Amin 
Published: October 2020

Abstract
Object: Hodgkin lymphoma (HL) is one of the pediatric and adult cancers, with a cure rate of over 90% and high long-term survival rates by treatment with chemotherapy alone or combined with radiotherapy (RT). However, survivors of pediatric HL are at high risk of secondary cancers and cardiovascular disease due to treatment. Considering the complications of RT, we aimed to evaluate the consequences and outcomes of the treatment with and without RT in a retrospective study in the pediatric oncology department of Urmia medical sciences university.Method: We carried a cross-sectional retrospective study by referring and review of records for all patients admitted in Motahari hospital with HL diagnosis from 1995 to 2016. The incomplete records and taking chemotherapy out of protocol were our exclusion criteria. The staging of disease was classified by the Ann Arbor staging system.Results: 35 patients enrolled in our study that 54.3% were female and 45.7% were male patients. The mean age of patients was 10.08±6.38 years. 10 (28.6%) cases classified in stage 1, 13 (37.1%) case in stage 2, 9 (25.7%) cases in stage 3, and 3 (8.6%) cases in stage 4. 30 patients (85.7%) were treated by chemotherapy and 5 (14.3%) patients with chemotherapy and radiation combination. In our study, the overall survival was 97.1% of patients who treated with chemotherapy alone and one patient died due to drug side effects. That is comparable with the result of other studies that treated patients with chemotherapy and radiotherapy.Conclusion: According to our findings chemotherapy without radiotherapy as initial treatment in Hodgkin lymphoma would have similar results of concomitant radiotherapy and chemotherapy, so with consideration of cost and harms of radiation therapy, we suggest a limitation of radiation therapy to patients with resistant disease that do not respond to chemotherapy solo-protocols.
Impulsivity Mediates the Association Between Parenting Styles and Self-harm in Chinese Adolescents
Authors: Ran Hailiang , Fang Die , Donald Ahouanse Roland , Wang Rui , Che Yusan , He Xingting , Wang Tianlan , Xu Xiufeng , Lu Jin , Xiao Yuanyuan 
Published: October 2020

Abstract
Background: Parenting styles were positively associated with self-harm (SH) in adolescents. Nevertheless, little is known concerning the mechanism behind this association. This study primarily aims to evaluate the potential mediation of impulsivity in the association between parenting styles and SH in Chinese adolescents. Methods: A population-based sample of 3146 adolescents in southwest China were surveyed by using self-administered questionnaires. Logistic regression analyses were used to measure the association between parenting styles and SH. Path model further examined mediation of impulsivity in this association. Results: The prevalence of SH was 47.0% (95% CI: 36.3%-58.0%). Impulsivity and mother’s over-protection were significantly associated with SH. Impulsivity showed a salient mediation, accounting for 23.4% of the total association. Parenting styles of father and mother showed disparate roles in the hypothesized path model. Conclusions: Our major findings suggested that, for Chinese adolescents with harsher maternal parenting style, impulsivity-centered intervention measures might be effective in reducing parenting style related SH.
Intervertebral foramen injection of plerixafor attenuates CCD-induced low back&nbsp;pain&nbsp;in&nbsp;rats through down-regulation of Nav1.8 and Nav1.9
Authors: Yang Fei , Wu Huang-Hui , Chen Lu , Chen Guo-Zhong , Wu Xiao-Zhi 
Published: October 2020

Abstract
BackgroundLow back pain, an extremely common chronic pain, is now the number one cause of disability globally. On the chronic compression of the dorsal root ganglion (CCD) model, a typical low back pain model, previous study has discovered that C-X-C chemokine receptor type 4 (CXCR4) involved in mediating low back pain. However, the underlying molecular mechanisms and whether it has the potential to serve as an applicable target for clinical treatment of low back pain remains unclear. MethodsCCD-induced low back pain model was established by inserting stainless steel L-shape rod into the intervertebral foramen at L5 level. Multiple pain behaviors including mechanical hyperalgesia and allodynia, thermal hyperalgesia and cold allodynia were evaluated. The role of CXCR4 in CCD-induced pain was assessed by intraganglionar CXCR4 siRNA injection and intervertebral foramen injection of plerixafor, a selective CXCR4 antagonist. The expression change of CXCR4, Nav1.8 and Nav1.9 was examined by immunofluorescent staining.ResultsWe showed that the CXCR4 were dramatically up-regulated in the compressed dorsal root ganglion (DRG) neurons in CCD model, and intraganglionar CXCR4 siRNA injection significantly reduced CCD-induced multiple pain behaviors, including mechanical hyperalgesia and allodynia, thermal hyperalgesia and cold allodynia. The expression of Nav1.8 and Nav1.9 in the compressed DRG were also enhanced after CCD, and which were remarkably reversed by intervertebral foramen injection of plerixafor at the compression level. Moreover, intervertebral foramen injection at the compression level of plerixafor and ropivacaine as well as A-803467, a Nav1.8 selective blocker, were all able to reverse CCD-induced multiple pain behaviors. However, the analgesic duration of plerixafor maintained at least for 24 h which was much longer than that of A-803467 and ropivacaine. Finally, we found intervertebral foramen injection of plerixafor at the adjacent non-compression level has no effect on CCD-induced pain and intervertebral foramen injection of plerixafor in normal rats did not affect their basal pain sensitivity.ConclusionsOur study provides evidence that CXCR4-Nav1.8/Nav1.9 axis in compressed DRG contributed to CCD-induced low back pain and intervertebral foramen injection of plerixafor was a potential and applicable therapeutic strategy for the treatment of low back pain.
IgM Mesangial Deposition Predicts Relapses of Adult-Onset Minimal Change Disease
Authors: Yang Cheng-Wen , Chen Fan-Yu , Chang Fu-Pang , Ho Yang , Yang An-Hang , Tarng Der-Cherng , Yang Chih-Yu 
Published: October 2020

Abstract
Background: Immunoglobulin M (IgM) mesangial deposition in pediatric minimal change disease (MCD) has been reported to be associated with steroid dependence and poor renal outcomes. However, the evidence regarding the impact of IgM mesangial deposition on the treatment responses or outcomes in adult-onset MCD is lacking.Methods: In this retrospective cohort study, 37 adult patients with MCD received kidney biopsy from January 2010 to May 2020. According to IgM mesangial deposition by immunofluorescence microscopy, the patients were divided into two groups (12 patients with positive IgM deposition; 25 patients with negative IgM deposition). We analyzed the clinical features, the dosage of immunosuppressive agents, and the response to treatment for two years between the two groups.Results: Regarding the clinical symptoms, the dosage of immunosuppressive treatment, and the time to remission, there was no statistically significant difference between the two groups. Compared to the negative IgM group, the frequency of relapses was significantly higher in the positive IgM group within the two-year follow-up period (the negative IgM group 0.25 episodes/year; the positive IgM group 0.75 episodes/year, p = 0.029). Furthermore, multivariate linear regression revealed that the positivity of IgM mesangial deposition is independently associated with the frequency of relapses (regression coefficient B 0.450, 95% CI 0.116-0.784, p = 0.010).Conclusions: Our findings indicated that adult-onset MCD patients with IgM mesangial deposition have a high risk of relapses. Therefore, prolonged and combined immunosuppressive therapy with close follow-up may be considered in MCD adults with IgM mesangial deposition.
Genetic Susceptibility to Multiple Sclerosis: Interactions between Conserved Extended Haplotypes of the MHC and other Susceptibility Regions
Authors: Goodin Douglas S , Khankhanian Pouya , Gourraud Pierre-Antoine , Vince Nicolas 
Published: October 2020

Abstract
BACKGROUNDTo study the accumulation of MS-risk resulting from different combinations of MS-associated conserved-extended-haplotypes (CEHs) of the MHC and three non-MHC “risk-haplotypes” nearby genes EOMES, ZFP36L1, and CLEC16A. Many haplotypes are MS-associated despite having population-frequencies exceeding the percentage of genetically-susceptible individuals. The basis of this frequency-disparity requires explanation. MEHTODSWTCCC SNP-data was phased at the MHC and three non-MHC susceptibility-regions. CEHs at the MHC were classified into five haplotype-groups: (HLA-DRB1*15:01~DQB1*06:02~a1)-containing (H+); extended-risk (ER); all-protective (AP); neutral (0); and the single-CEH (c1). MS-associations for different “risk-combinations” at the MHC and other non-MHC “risk-loci” and the appropriateness of additive and multiplicative risk-accumulation models were assessed.RESULTSDifferent combinations of “risk-haplotypes” produce a final MS-risk closer to additive rather than multiplicative risk-models but neither model was consistent. Thus, (H+)-haplotypes had greater impact when combined with (0)-haplotypes than with (H+)-haplotypes, whereas, (H+)-haplotypes had greater impact when combined with a (c1)-haplotypes than with (0)-haplotypes. Similarly, risk-genotypes (0,H+), (c1,H+), (H+,H+) and (0,c1) were additive with risks from non-MHC risk-loci, whereas risk-genotypes (ER,H+) and (AP,c1) were unaffected.CONCLUSIONSGenetic-susceptibility to MS is essential for MS to develop but actually developing MS depends heavily upon both an individual’s particular combination of “risk-haplotypes” and how these loci interact.
Incidence and risk factors of micronutrient deficiency in patients with IBD and intestinal Behçet’s disease: Folate, Vitamin B12, 25-OH-vitamin D, and Ferritin
Authors: Park Yong Eun , Park Soo Jung , Park Jae Jun , Cheon Jae Hee , Kim TaeIl , Kim Won Ho 
Published: October 2020

Abstract
Background
Patients with inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) are vulnerable to micronutrient deficiencies due to diarrhea-related gastrointestinal loss and poor dietary intake caused by disease-related anorexia. However, few studies have investigated the incidence and risk factors for micronutrient deficiency.
Methods
We retrospectively analyzed 205 patients with IBD who underwent micronutrient examination, including folate, vitamin B12, 25-OH-vitamin D, and/or ferritin level quantification, with follow-up blood tests conducted 6 months later.
Results
Eighty patients (39.0%), who were deficient in any of the four micronutrients, were classified as the deficiency group, and the remaining 125 (61.0%) were classified as the non-deficient group. Compared to those in the non-deficiency group, patients in the deficiency group were much younger, had more Crohn's disease (CD) patients, more patients with a history of bowel operation, and significantly less 5-amino salicylic acid usage. Multivariate analysis revealed that CD and bowel operation were significant independent factors associated with micronutrient deficiency.
Conclusions
The incidence of micronutrient deficiency was high (39.0%). Factors including CD, bowel operation, and younger ages were found to be associated with higher risks of deficiency. Therefore, patients with IBD, especially young patients with CD who have undergone bowel resection surgery, need more attention paid to micronutrition.
Development and Validation of a Hypoxia-Related Gene Pairs Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma
Authors: Ding Zhao , Li Hefeng , Yu Deshun 
Published: October 2020

Abstract
Objective Head and neck squamous cell carcinoma (HNSCC) are a highly aggressive tumor with an extremely poor prognosis. Thus, we aimed to develop and validate a robust prognostic signature that can estimate the prognosis for HNSCC.Methods Data on gene expressions and clinical were downloaded from TCGA and GEO database. To develop the best prognosis signature, a LASSO Cox Regression model was employed. Time-dependent receiver-operating characteristic (ROC) was used to determine the best cut-off value. Patients were divided into high-risk and low-risk hypoxia groups according to cut-off value. Survival differences were evaluated by log-rank test, while multivariate analysis was performed by a Cox proportional hazards model.Results A 17-HRGPs composed of 24 unique genes was constructed, which was significantly related to OS. In the TCGA and GEO datasets, patients in the high hypoxia risk group have a poor prognosis (TCGA: P < 0.001, GEO: P < 0.05). After adjusting for other clinicopathological parameters, the 17-HRGP signature was independent prognostic factors in patients with HNSCC (P < 0.05). Functional analysis revealed that mRNA binding, gene silencing by RNA, RNA binding involved in posttranscriptional gene silencing signaling pathway were enriched in the low-risk groups. For this model, C-index was 0.684, which was higher than that of many established risk models. Macrophages M0, Mast cells activated, NK cells resting, and T cells CD4 memory resting, etc. were significantly higher in the high-risk group, and B cells memory, Plasma cells, T cells follicular helper, T cells gamma delta, and T cells CD8, etc. were significantly higher in the low-risk group.Conclusion In summary, our study constructed a robust HRGPs signature as molecular markers for predicting the outcome of HNSCC patients.
Application of Modified Michaelis – Menten Equations for Determination of Enzyme Inducing and Inhibiting Drugs
Authors: Saganuwan Saganuwan Alhaji 
Published: October 2020

Abstract
Pharmacokinetics is the process of absorption, distribution, metabolism and elimination (ADME) of drugs. Some drugs undergo zero-order kinetics (e.g. ethyl alcohol,) first order kinetics (e.g. piroxicam) and mixed order kinetics (e.g. ascorbic acid). Drugs that undergo Michaelis-Menten metabolism are characterized by either increased or decreased Km and Vmax. Hence literatures were searched with a view to translating in vitro-in vivo enzyme kinetics to pharmacokinetic/pharmacodynamic parameters for determination of enzyme inducing and inhibiting drugs inorder to achieve optimal clinical efficacy and safety. Findings have shown that theophylline, voriconazole, phenytoin, thiopental, fluorouracil, thyamine and thymidine are enzyme inducers whereas mibefradil , metronidazole isoniazid and puromicin are enzyme inhibitors. They are metabolized and eliminated according to Michaelis-menten principle. The order could be mixed but may change to zero or first order depending on drug concentrations and frequency of drug administration. Hence, pharmacokinetic-pharmacodynamic translation can be optimally achieved by incorporating newly derived Michaelis-Menten equations into pharmacokinetic parameters for clinical efficacy and safety of therapeutics.
Analysis of the Effect of Duloxetine in the Treatment of Early Pain After Total Knee Arthroplasty
Authors: Wang Tao , He Sen 
Published: October 2020

Abstract
OBJECTIVE: Total knee arthroplasty is one of the most effective treatments for advanced degeneration of the knee. Knee replacement surgery has achieved excellent clinical results, not only solving the patients' pain, but also solving the social problems. The objective of this study was to examine the effect of duloxetine, a selective serotonin norepinephrine reuptake inhibitor, on the treatment of early pain in patients after TKA.METHODS: The study is a randomized controlled trial. Sixty patients who underwent TKA from January 2020 to June 2020 were selected for inclusion in the study, and equally assigned to a celecoxib group and a duloxetine group. There were 22 males and 38 females; the average age was 60.3±5.1 (56-74) years. The celecoxib group was given celecoxib 200mg/bid. The duloxetine group received duloxetine 30mg/bid. Analgesic medication was applied from the first postoperative day in the two groups for 4 weeks. The effectiveness of analgesia was assessed by the postoperative VAS walking pain score, HAMD-17 (Hamilton Depression Scale) score and the WOMAC pain score (Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC). The proportion of adverse events in the two groups was also compared to further evaluate the analgesic effect and safety. RESULTS: There was no significant difference in VAS score between groups on postoperative day three but duloxetine was superior to the celecoxib group at postoperative weeks one, two and four (p < 0.05). The HAMD-17 scores in both groups decreased at week four compared to preoperative values (p < 0.05), but the duloxetine group's HAMD-17 score was superior to the celecoxib group four weeks postoperatively (P < 0.05). The WOMAC pain scores of the duloxetine group were superior to the celecoxib group (P < 0.05) at postoperative weeks one, two and four. There was no significant difference in the incidence of adverse events.CONCLUSION: Duloxetine has a good effect on postoperative analgesia after TKA and can relieve patients' depression and anxiety, and promote rapid recovery. Thus, we can infer that duloxetine can be used to treat early postoperative pain after knee arthroplasty.
WITHDRAWN: Treatment Outcomes of Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy
Authors: Yeh Shyh-An , Hwang Tzer-Zen , Wang Chih-Chun , Yang Chuen-Chien , Lien Ching-Feng , Wang Chien-Chung , Hsu Tun-Yen , Hsu Ruey-Feng , Shih Yu-Chen , Huang Yaw-Chang , Hsieh Meng-Che , Gau Jhy-Shyan , Chang Liyun , Lee Tsair-Fwu 
Published: October 2020

Abstract
Background: Nasopharyngeal cancer shows good response to intensity-modulated radiotherapy. However, there is no clear evidence for the benefits of routine application of image-guided radiotherapy. The purpose of this study was to perform a retrospective investigation of the treatment outcomes, treatment-related complications and prognostic factors for nasopharyngeal cancer treated with intensity-modulated radiotherapy and image-guided radiotherapy techniques.Methods: Retrospective analysis was carried out on 326 consecutive nasopharyngeal cancer patients treated between 2004 and 2015. Potentially significant patient-related and treatment-related variables were analyzed. Radiation-related complications were recorded.Results: The 5-year overall survival and disease-free survival rates of these patients were 77.9% and 70.5% respectively. Age, AJCC stage, retropharyngeal lymphadenopathy, treatment interruption, and Body Mass Index were independent prognostic factors for overall survival. Age, AJCC stage, retropharyngeal lymphadenopathy, image-guided radiotherapy, and Body Mass Index were independent prognostic factors for disease-free survival.Conclusion: Intensity-modulated radiotherapy significantly improves the treatment outcomes of nasopharyngeal cancer. With the aid of image-guided radiotherapy, the advantage of intensity-modulated radiotherapy might be further amplified.
Tumor Specific Hypoxia-Activated Expression of Cardiac Peptides Using an Engineered Subtype of Escherichia Coli Suppresses Tumor Growth, Angiogenesis and Metastasis in Mouse Model of Breast Cancer
Authors: Darvishi Behrad , Samadi Mitra , Majidzadeh-A Keivan , Salehi Malihe , Jalili Neda , Noorinejad Zeinab , Mosayebzadeh Marjan , Mohammadnejad Ahad , Sharifkhatibi Azadeh , Moradi-kalbolandi Shima , farahmand leila 
Published: October 2020

Abstract
BackgroundApplication of genetically modified non-pathogenic bacteria expressing specific anti-tumor proteins under certain conditions specific to tumors is an effective approach for selective targeting of tumors. We developed here, for the first time, a novel spatiotemporal cancer targeted therapy applying engineered E. coli bacteria with capability of expressing cardiac peptides under hypoxic conditions of tumor. MethodE. coli BW25133 was transformed with construction of co-expressing cardiac hormones and GFP. Bacteria bearing constructs were then IV administered in mice bearing tumors and then tumor localization, as well as tumor proliferation, invasion and angiogenesis biomarkers (Ki-67, VEGFR, CD31and MMP9), changes in cytokine profile, suppression of tumor growth and survival were analyzed. ResultsIV Administered bacteria bearing constructs could specifically localize at tumor site and express cardiac peptides under hypoxic conditions. Administration of bacteria significantly enhanced survival rate, suppressed tumor progression and lowered expression levels of MMP-9, VEGFR2, CD31 and Ki67 as potent markers for angiogenesis, tumor proliferation and metastasis. Furthermore, applied bacteria resulted in significant reduction in the expression of IL-1β, IL-6, GC-SF, IL-12 and TNF-α proinflammatory cytokines, whereas increasing IL-10, IL-17A and INF-γ cytokines. ConclusionOverall, administration of E. coli bearing cardiac hormone expression construct could effectively suppress tumor growth, angiogenesis, invasion and metastasis while enhancing survival rate in mice model of breast cancer.