bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Rituximab in Chinese Children With Refractory Anti-NMDAR Encephalitis
Authors: Dou Xiangjun , Li Dongjing , Wu Yan , Wang Zhijing , Yang Le , Ma Nan , Wang Dong , Li Xia 
Published: December 2020

Purpose: To assess the efficacy and safety of rituximab treatment as second-line immunotherapy in pediatric cases of anti-NMDA receptor (NMDAR) encephalitis.Methods: We retrospectively recruited 8 patients with anti-NMDAR encephalitis who were treated with rituximab as second-line immunotherapy. We evaluated the clinical features, laboratory examination results and treatment protocols of the Chinese children and defined good outcomes based on the modified Rankin scale (mRS) score (0–2) at the last follow-up.Results: A total of eight pediatric patients (median age 6.7 years; four female) with refractory anti-NMDAR encephalitis were recruited to the study. Rituximab was given after a median duration of disease of 57 days (range 50.5–113.75 days). The use of rituximab led to a significant reduction in the mRS and CD19+ B-cells compared to before rituximab infusion (P &lt; 0.05). Five patients (62.5%) had a good outcome (mRS ≤ 2) including four patients (50%) who showed complete recovery (mRS = 0) at the last follow-up. Transient infusion adverse events were recorded in 2 patients (25%). Two patients (25%) had severe infectious adverse events (AEs) and two patients with grade 5 (death). None of the patients developed progressive multifocal leukoencephalopathy (PML).Conclusion: Our study provides evidence that rituximab can efficiently improve the clinical symptoms of anti-NMDAR encephalitis in children. However, due to the risk of adverse infections, rituximab should be restricted in pediatric patients with high rates of mortality and disability.
The Effects of Stochastic Galvanic Vestibular Stimulation on Body Sway and Muscle Activity
Authors: Matsugi Akiyoshi , Oku Kosuke , Mori Nobuhiko 
Published: December 2020

Objective: This study aimed to investigate whether galvanic vestibular stimulation with stochastic noise (nGVS) modulates the body sway and muscle activity of the lower limbs, depending on visual and somatosensory information from the foot using rubber-foam.Methods: Seventeen healthy young adults participated in the study. Each subject maintained an upright standing position on a force plate with/without rubber-foam, with their eyes open/closed, to measure the position of their foot center of pressure. Thirty minutes after baseline measurements under four possible conditions (eyes open/closed with/without rubber-foam) performed without nGVS (intensity: 1 mA, duration: 40 s), the stimulation trials (sham-nGVS/real-nGVS) were conducted under the same conditions in random order, which were then repeated a week or more later. The total center of pressure (COP) path length movement (COP-TL) and COP movement velocity in the mediolateral (Vel-ML) and anteroposterior (Vel-AP) directions were recorded for 30 s during nGVS. Furthermore, electromyography activity of the right tibial anterior muscle and soleus muscle was recorded for the same time and analyzed.Results: Three-way analysis of variance and post-hoc multiple comparison revealed a significant increment in COP-related parameters by nGVS, and a significant increment in soleus muscle activity on rubber. There was no significant effect of eye condition on any parameter.Conclusions: During nGVS (1 mA), body sway and muscle activity in the lower limb may be increased depending not on the visual condition, but on the foot somatosensory condition.
Dibenzazepine Attenuates Against Cisplatin-Induced Nephrotoxicity in Rats: Involvement of NOTCH Pathway
Authors: Abd El-Rhman Rana H. , El-Naga Reem N. , Gad Amany M. , Tadros Mariane G. , Hassaneen Sherifa K. 
Published: December 2020

Cisplatin is one of the standard anti-cancer agents that are used to treat variety of solid tumors. Nevertheless, due to the accumulation of cisplatin in the renal epithelial cells, nephrotoxicity was found to be the main side effect that limits its clinical use. The current study was conducted to assess the potential nephroprotective effect of dibenzazepine, a Notch inhibitor, against cisplatin-induced nephrotoxicity in rats as well as the possible mechanisms underlying this nephroprotection. The rats were pre-treated with 2 mg/kg dibenzazepine for 7 days before giving a single nephrotoxic dose of cisplatin (7 mg/kg). Cisplatin induced acute nephrotoxicity, where blood urea nitrogen and serum creatinine levels were significantly increased. Besides, lipid peroxidation was markedly elevated and the levels of reduced glutathione and catalase were significantly reduced. Also, the tissue levels of the pro-inflammatory mediators; IL-1β, TNF-α, and NF-kB, were significantly increased in the cisplatin group. The pre-treatment with dibenzazepine significantly mitigated the nephrotoxic effects of cisplatin, the oxidative stress and inflammatory status as well as decreased caspase-3 expression, as compared to the cisplatin group. Furthermore, the up-regulation of Notch-1 and Hes-1 was found to be involved in cisplatin-induced nephrotoxicity and their expression was significantly reduced by dibenzazepine. The nephroprotective effect of dibenzazepine was further confirmed by the histopathological assessment. Moreover, dibenzazepine pre-treatment of hela and PC3 cellsin vitrodid not antagonize the cisplatin anti-cancer activity. In conclusion, these findings show that dibenzazepine provides protection against cisplatin-induced nephrotoxicity. Moreover, the up-regulation of the Notch pathway was shown to play a role in the pathogenesis of cisplatin-induced renal injury.
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteers
Authors: Liu Jingrui , Lv Binhua , Yin Hewen , Zhu Xiaoxue , Wei Haijing , Ding Yanhua 
Published: December 2020

Background: Jaktinib is a novel selective janus kinase 1/2 inhibitor. The phase I first-in-human study evaluated the tolerance and pharmacokinetics of jaktinib in healthy Chinese subjects.Methods: A randomized, double-blind, placebo-controlled study were designed. A total of 126 healthy subjects were enrolled into the single ascending dose, multiple ascending dose and food effect study. Safety endpoints included adverse events, abnormal vital signs, 12-lead ECGs, abdominal ultrasound, chest x-ray, physical examination and clinical laboratory tests. Blood, urine and feces samples were collected at predetermined time points for pharmacokinetic analysis of jaktinib, the metabolites ZG0244 and ZG0245, which are formed by oxidation or hydrolysis metabolic pathway, respectively.Results: Jaktinib was absorbed with a median time to peak plasma concentration of 1.25–3.5 h and was eliminated with a half-life of 2.952–9.040 h. Linear pharmacokinetic characteristic was presented over the dose range from 25 to 400 mg. No obvious accumulation was observed after multiple doses for 10 days. Administration after a high-fat breakfast significantly increased the absorption of jaktinib. The accumulated fraction of jaktinib and the determined metabolites excreted in urine and feces was 19.478%. Jaktinib was well tolerated in all single dose cohorts. In multiple dose cohorts, 200 mg q24 h method was evaluated as maximally tolerated dose. Neutropenia, diarrhea, dizziness and headache were the most frequently reported treatment related adverse events. No deaths, serious or Grade ≥4 adverse events was developed.Conclusion: Jaktinib was well tolerated when single dose ranging from 25 to 400 mg and multiple dose up to 200 mg q24 h. The safety and pharmacokinetic characteristics support the next trial in myelofibrosis patients.
Long-Term Effect of Adverse Childhood Experiences, School Disengagement, and Reasons for Leaving School on Delinquency in Adolescents Who Dropout
Authors: Bae Sung Man 
Published: December 2020

Purpose: The purpose of this study was to verify the long-term effect of adverse childhood experiences (ACEs), school disengagement, and the reasons for leaving school on adolescent delinquency while adjusting for sex.Methods: Data were collected from 663 teenagers [male 368, female 295; mean age = 16.81 (SD = 1.10); age range = 13–19 years] through a Longitudinal Survey and Support Plan for Dropouts.Results: Multivariate latent growth modeling (LGM) demonstrated that ACEs and school disengagement are positively associated with delinquency and the mediating effect of school disengagement on association between ACEs and delinquency was verified. Teenagers who quit school for personal reasons reported fewer instances of delinquent behavior than adolescents who left because of school reasons.Conclusion: This study suggests that researchers and teachers need to consider ACEs and school disengagement as a warning index for delinquency with school dropout. In addition, the reason for leaving school should be considered to clarify the effect of school dropout on delinquency in adolescents who dropout.
Alterations of Cognition and Cerebral Ventricle Volume in Manic and Euthymic Pediatric Bipolar Disorder
Authors: Kuang Liangfeng , Cui Dong , Jiao Qing , Guo Yongxin , Cao Weifang , Gao Weijia , Qiu Jianfeng , Su Linyan , Lu Guangming 
Published: December 2020

Introduction: It remains unknown whether volumetric alterations of ventricles are similar or not in pediatric bipolar disorder (PBD) among different mood states. The present study aims to estimate ventricular volumetric alteration of PBD patients in manic and euthymic status, as well as the relationship between this alteration and cognitive changes.Methods: T1 magnetic resonance images were obtained from 20 manic PBD patients, 21 euthymic PBD patients, and 19 healthy controls (HCs). Ventricular volumes were automatically obtained via FreeSurfer 6.0 software. Ventricular volumes and cognitive indices were compared among the three groups, and the relationship between ventricular volumes and cognitive/clinical indices was analyzed.Results: In contrast to HCs, manic and euthymic PBD patients exhibited decreased cognitive scores of the Stroop color-word test and the digit span subtest. Manic PBD subjects presented enlarged volumes in the bilateral ventricles, third ventricle, and whole ventricles, and euthymic PBD participants displayed increased volumes in the third ventricle, fourth ventricle, and whole ventricles. No significant differences in cognitive performance and ventricular volumes were found between PBD groups. No significant correlation was discovered between ventricular volumes and cognitive/clinical indices in both manic and euthymic PBD patients.Conclusions: No significant differences in cognitive performance and ventricle volume were observed between euthymic and manic PBD groups, which may imply that the alterations are not specific to mood state. It may indicate structural and functional damage of corresponding brain circuits in euthymic PBD patients similar with that of manic PBD, which may provide clues to the diagnosis and treatment of euthymic PBD.
Impact of Relaxing Covid-19 Social Distancing Measures on Rural North Wales: A Simulation Analysis
Authors: Hughes Rhodri P. , Hughes Dyfrig A. 
Published: December 2020

Background: Social distancing policies aimed to limit Covid-19 across the UK were gradually relaxed between May and August 2020, as peak incidences passed. Population density is an important driver of national incidence rates; however peak incidences in rural regions may lag national figures by several weeks. We aimed to forecast the timing of peak Covid-19 mortality rate in rural North Wales.Methods: Covid-19 related mortality data up to 7/5/2020 were obtained from Public Health Wales and the UK Government. Sigmoidal growth functions were fitted by non-linear least squares and model averaging used to extrapolate mortality to 24/8/2020. The dates of peak mortality incidences for North Wales, Wales and the UK; and the percentage of predicted mortality at 24/8/2020 were calculated.Results: The peak daily death rates in Wales and the UK were estimated to have occurred on the 14/04/2020 and 15/04/2020, respectively. For North Wales, this occurred on the 07/05/2020, corresponding to the date of analysis. The number of deaths reported in North Wales on 07/05/2020 represents 33% of the number predicted to occur by 24/08/2020, compared with 74 and 62% for Wales and the UK, respectively.Conclusion: Policies governing the movement of people in the gradual release from lockdown are likely to impact significantly on areas–principally rural in nature–where cases of Covid-19, deaths and immunity are likely to be much lower than in populated areas. This is particularly difficult to manage across jurisdictions, such as between England and Wales, and in popular holiday destinations.
Efficiency of Salicornia neei to Treat Aquaculture Effluent from a Hypersaline and Artificial Wetland
Authors: Diaz Mónica R. , Araneda Javier , Osses Andrea , Orellana Jaime , Gallardo José A. 
Published: December 2020

In this study, we evaluated the potential of Salicornia neei, a halophyte plant native to South America, to treat saline effluents with simulated concentration of ammonium-N (Amm) and nitrate-N (Nit) in a similar manner to land-based marine aquaculture effluents. Plants were cultivated for 74 days in drainage lysimeters under three treatments of seawater fertilized with: (1) Nit + Amm, (2) Nit, or (3) without fertilizer (Control). Over five repetitions, nitrogen removal efficiency (RE) was high in both treatments (Nit + Amm = 89.6% ± 1.0%; Nit 88.8% ± 0.9%), whereas the nitrogen removal rate (RR) was nonlinear and concentration-dependent (RRday1–4: Nit + Amm = 2.9 ± 0.3 mg L−1 d−1, Nit = 2.4 ± 0.5 mg L−1 d−1; RRday5–8: Nit + Amm = 0.8 ± 0.2 mg L−1 d−1, Nit = 1.0 ± 0.2 mg L−1 d−1). Effluent salinity increased from 40.6 to 49.4 g L−1 during the experiment, with no observed detrimental effects on RE or RR. High nitrogen removal efficiency and significant biomass production were observed (Nit + Amm = 11.3 ± 2.0 kg m−2; Nit = 10.0 ± 0.8 kg m−2; Control = 4.6 ± 0.6 kg m−2) demonstrate that artificial wetlands of S. neei can be used for wastewater treatment in saline aquaculture in South America.
“Renovação” do Serviço Social brasileiro
Authors: Cisne Mirla , Batista de Oliveira Cantalice Luciana , Araújo Luciene 
Published: December 2020

Nosso objetivo geral é analisar as condições sócio históricas do tempo presente, considerando as mediações com os fundamentos do conservadorismo e alguns de seus rebatimentos para o Serviço Social, especialmente em relação aos desafios que a profissão enfrenta em seu processo de “renovação”. Utilizamos o materialismo histórico dialético como método de análise do objeto em questão: Serviço Social, conservadorismo e “renovação” profissional na atualidade. Para tanto, realizamos uma pesquisa bibliográfica e documental, de tipo qualitativo. Defendemos como conclusão central, que o processo de “renovação” profissional configura-se como um movimento continumm, no confronto com as reatualizações conservadores, o que demanda uma sintonia do Projeto Ético Político do Serviço Social com as lutas classistas, feministas e antirracistas.
Evaluation of migraine without aura patients by visual evoked potentials with different spatial frequencies
Authors: ATAÇ Ceyla , TUNA Ezgi 
Published: December 2020

Objective: The objective of our study was to investigate changes in pattern reversal visual evoked potentials (PVEPs) of migraine without aura patients recorded with two different check sizes (15’ and 62’) in accordance with International Society for Clinical Electrophysiology of Vision (ISCEV) standards during the interictal period.
Materials and Methods: Patients' demographic data were documented from headache diaries of patients, such as duration of disease, headache characteristics, the number of attacks in a month, the average duration of attacks, complaints accompanying headache, mean severity of headache according to visual analog scale. Twenty migraine patients without aura and 14 healthy volunteers were examined with PVEPs recorded with two different check-sizes (15’ and 62’). The stimulation sequences were randomized both for the check-size of checkerboard and the side of stimulation (right-15', right-62', left-15', left-62'). The latency of N75, P100 and peak-to-peak amplitude of N75-P100
were analyzed.
Results: There were no statistical difference between healthy subjects and migraine without aura patients in the means of latency and amplitude of PVEPs results for both check-sizes (p>0,05).
Conclusion: In migraine patients without aura, we did not detect magnocellular pathway dysfunction by PVEPs with different spatial frequencies. Studies on larger patient groups and combining PVEPs with psychophysical tests are needed.
Trombosis séptica de senos cavernosos secundaria a celulitis facial
Authors: Méndez Ramírez Erick , Chacón Arce Pedro Pablo 
Published: December 2020

La trombosis séptica del seno cavernoso es una enfermedad rara que se presenta como una tromboflebitis en el seno cavernoso como complicación posterior a infecciones faciales, principalmente en la zona denominada zona de peligro ( tercio medio de la cara , alrededor de ojos y nariz ) zona que drena en la venas oftálmicas; además ,rinosinusitis (especialmente esfenoiditis y etmoiditis, celulitis, abscesos ,otitis media, , faringitis y con menos frecuencia infecciones dentales(1).
Se puede presentar como un cuadro agudo que puede ser dramático y potencialmente mortal sin embargo en raras ocasiones se presenta como un cuadro subagudo o crónico. Su elevada morbimortalidad amerita que se realice un diagnóstico rápido y certero que evite secuelas graves.
Se presenta el caso de un hombre que acude al servicio de emergencias con cuadro agudo de fiebre, eritema, dolor a nivel nasal y salida de secreción purulenta posterior a trauma punzante que posteriormente se diagnostica una trombosis séptica bilateral de senos cavernosos secundaria a una celulitis facial.
Enhanced activation of Mg ion-implanted GaN at decreasing annealing temperature by prolonging duration
Authors: Nakashima Takuya , Kano Emi , Kataoka Keita , Arai Shigeo , Sakurai Hideki , Narita Tetsuo , Sierakowski Kacper , Bockowski Michal , Nagao Masahiro , Suda Jun , Kachi Tetsu , Ikarashi Nobuyuki 
Published: December 2020

Abstract
Defect time-evolution was investigated in Mg ion-implanted GaN after annealing at 1573 K for an unprecedentedly long duration. Transmission electron microscopy directly revealed that annealing for over 30 min reduced defects inhibiting Mg activation, just like annealing at 1753 K for a short duration. The cathodoluminescence intensity of donor–acceptor pair originating from Mg acceptors increased as the duration increased, and the intensity after annealing for 60 min was higher than after short-duration annealing at 1753 K. These show the potential of lowering the annealing temperature by prolonging the duration, which would lead to practical annealing technology for Mg ion-implanted GaN.
Self-sweeping ytterbium-doped fiber laser based on a fiber saturable absorber
Authors: Wen Zengrun , Wang Kaile , Chen Haowei , Lu Baole , Bai Jintao 
Published: December 2020

Abstract
Generally speaking, the self-sweeping effect relies on the dynamical grating formed in active fiber. Here, the normal self-sweeping was generated in a ytterbium-doped fiber which serves as a fiber saturable absorber and is introduced to the laser cavity by a circulator in this experiment. The sweeping rate and the sweeping range alter as usual, both of which can be controlled by the pump power. Further, a new self-pulse signal is observed and discussed, which shows both the grating feature and saturable absorption of YDFSA. Our work provides a new self-sweeping way and can act as a platform to further deeply study this effect.
Peran Kurkumin Sebagai Terapi Pada Osteoartritis
Authors: Abelira Rilianda 
Published: December 2020

Osteoartritis (OA) merupakan salah satu penyakit penyakit degeneratif atau geriatri yang disebabkan adanya inflamasi yang melibatkan kartilago, lapisan sendi, ligamen, dan tulang yang akibatnya dapat menyebabkan nyeri dan kekakuan pada sendi. Epidemiologi OA di didunia sekitar 15% dengan usia diatas 65-75 dan diperkirakan pada tahun 2020 penderita osteoarthritis akan meningkat 11,6 juta penderita. Kejadian OA di Indonesia dari tahun 1990 hingga 2010 telah mengalami peningkatan sebanyak 44,2% dan berdasarkan usia di Indonesia cukup tinggi dengan 65% pada usia tua (lansia) atau lebih dari 61 tahun. Pengobatan secara farmakologis untuk OA dengan menggunakan Obat Anti Inflamasi Non-Steroid (OAINS) salah satu contohnya adalah meloksikam. Namun, efek samping penggunaan OAINS dapat menimbulkan beberapa masalah seperti timbulnya ulkus peptikum dan gangguan pencernaan. Hal ini menyebabkan sedang dikembangkannya pengobatan herbal untuk OA yang harapannya dapat menjadi pengobatan utama dalam mengatasi OA dengan menggunakan kurkumin. Kurkumin berperan sebagai antiinflamasi dalam kunyit putih dengan menurunkan aktivitas cyclooxygenase 2(COX-2), lipoxygenase dan menghambat produksi sitokin seperti TNF-α, interleukin (IL).
Osteoarthritis (OA) is a degenerative or geriatric disease that is caused by inflammation involving cartilages, joint lining, ligaments, and bones which can cause pain and stiffness in the joints. Epidemiology of OA in the world around 15% with ages above 65-75 and it is estimated in 2020, osteoarthritis will increase by 11.6 million. The incidence of OA in Indonesia from 1990 to 2010 has increased by 44.2% and by age in Indonesia is quite high with 65% in old age (elderly) or more than 61 years. Treatment for OA is using non-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam. However, side effects of NSAID use can cause several problems such as the emergence of peptic ulcer and digestive disorders. This has led to the development of herbal treatments for OA which hopes to become the main treatment in overcoming OA by using curcumin. Curcumin acts as an anti-inflammatory in white turmeric by reducing the activity of cyclooxygenase 2 (COX-2), lipoxygenase and inhibiting the production of cytokines such as TNF-α, interleukin (IL).
PENGARUH PENERAPAN GOOD GOVERNANCE DAN STANDAR AKUNTANSI PEMERINTAH TERHADAP AKUNTABILITAS KEUANGAN KECAMATAN DI KABUPATEN BARITO KUALA
Authors: Yudi rahman  
Published: December 2020

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh secara simultan dan parsial Penerapan Good Governance dan Standar Akuntansi Pemerintah Terhadap Akuntabilitas Keuangan Kecamatan di Kabupaten Barito Kuala.
Jenis dari penelitian yang digunakan peneliti adalah peneitian kuantitatif. Penelitian kuantitatif dilakukan dengan cara statistik, yakni menganalisa dengan berbagai dasar statistik dengan cara membaca tabel, grafik atau angka yang telah tersedia kemudian dilakukan beberapa uraian atau penafsiran dari data-data tersebut. Untuk penentuan metode analisa data dapat dilihat dari tujuan dan jenis penelitian yang dilakukan dan model data yang ada.Teknik pengumpulan data berupa dokumentasi, menyelidiki benda-benda tertulis seperti buku-buku, majalah, jurnal dan lain-lain, guna mendapatkan referensi untuk menjadi dasar dari penelitian.
Hasil penelitian pada penelitian ini menunjukan Secara Simultan Penerapan Good Governance Dan Standar Akuntansi Pemerintah Terhadap Akuntabilitas Keuangan Kecamatan Di Kabupaten Barito Kuala.Variabel Penerapan Good Governance berpengaruh signifikan terhadap Akuntabilitas Keuangan Kecamatan Di Kabupaten Barito Kuala secara parsial.Variabel Standar Akuntansi Pemerintah berpengaruh signifikan terhadap Akuntabilitas Keuangan Kecamatan Di Kabupaten Barito Kuala secara parsial.
Kata Kunci :Penerapan Good Governance, Standar Akuntansi Pemerintah, Akuntabilitas Keuangan