bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle information and commercial weight management groups to support maternal postnatal weight management and positive lifestyle behaviour: the SWAN feasibility randomised controlled trial
Authors: Bick D , Taylor C , Bhavnani V , Healey A , Seed P , Roberts S , Zasada M , Avery A , Craig V , Khazaezadah N , McMullen S , O'Connor S , Oki B , Ntim EO , Poston L , Ussher M 
Published: December 2019

ObjectivesTo assess feasibility of a future randomised controlled trial (RCT) of clinical and cost‐effectiveness of lifestyle information and commercial weight management groups to support postnatal weight management to 12 months post‐birth.DesignTwo‐arm feasibility trial, with nested mixed‐methods process evaluation.SettingInner‐city unit, south England.PopulationWomen with body mass indices (BMIs) ≥25 kg/m2 at pregnancy booking or normal BMIs (18.5–24.9 kg/m2) identified with excessive gestational weight gain at 36 weeks of gestation.MethodsRandomised to standard care plus commercial weight management sessions commencing 8–16 weeks postnatally or standard care only.Main outcomesFeasibility outcomes included assessment of recruitment, retention, acceptability and economic data collation. Primary and secondary end points included difference between groups in weight 12 months postnatally compared with booking (proposed primary outcome for a future trial), diet, physical activity, smoking, alcohol, mental health, infant feeding, NHS resource use.ResultsIn all, 193 women were randomised: 98 intervention and 95 control; only four women had excessive gestational weight gain. A slightly greater weight change was found among intervention women at 12 months, with greatest benefit. Among women attending ten or more weight management sessions. There was >80% follow up to 12 months, low risk of contamination and no group differences in trial completion.ConclusionIt was feasible to recruit and retain women with BMIs ≥25 kg/m2 to an intervention to support postnatal weight management; identification of excessive gestational weight gain requires consideration. Economic modelling could inform out‐of‐trial costs and benefits in a future trial. A definitive trial is an important next step.Tweetable abstractA feasibility RCT of postnatal weight support showed women with BMIs ≥25 kg/m2 can be recruited and followed to 12 months postnatally.
Using data mining to predict emergency department length of stay greater than 4 hours: Derivation and single‐site validation of a decision tree algorithm
Authors: Rahman Md Anisur , Honan Bridget , Glanville Thomas , Hough Peter , Walker Katie 
Published: December 2019

AbstractObjectivesHealth services have an imperative to reduce prolonged patient length of stay (LOS) in ED. Our objective is to develop and validate an accurate prediction model for patient LOS in ED greater than 4 hours using a data mining technique.MethodsData were collected from a regional Australian public hospital for all ED presentations between 1 January 2016 and 31 December 2017. A decision tree algorithm was built to predict patients with an ED LOS >4 hours. A total of 33 attributes were analysed. The performance of the final model was internally validated. Clinically relevant patterns from the model were analysed.ResultsThe accuracy of the model was 85%. We identified that patients at our site who were at high risk of ED LOS >4 hours were those who were waiting in ED for a medical consultation, or those who were waiting for a urology, surgical, orthopaedic or paediatric consultation if the request for consultation occurred more than 2 hours after the patient was first seen by an ED doctor.ConclusionThis model performed very well in predicting ED LOS >4 hours for each individual patient and demonstrated a number of clinically relevant patterns. Identifying patterns that influence ED LOS is important for health managers in order to develop and implement interventions targeted at those clinical scenarios. Future work should look at the utility of displaying individual patient risk of ED LOS >4 hours using this model in real‐time at the point‐of‐care.
Increasing insulin resistance predicts adverse pregnancy outcomes in women with gestational diabetes mellitus
Authors: Sun Yi‐Ying , Juan Juan , Xu Qian‐Qian , Su Ri‐Na , Hirst Jane E. , Yang Hui‐Xia 
Published: December 2019

AbstractBackgroundThis study aimed to investigate the association between maternal insulin resistance (IR) in the late second trimester and pregnancy outcomes, as well as to identify risk factors of IR among women with gestational diabetes mellitus (GDM).MethodsA retrospective study was conducted among 2647 women diagnosed with GDM. IR was evaluated using the homeostasis model assessment method for IR (HOMA‐IR) in the late second trimester (between 24 and 28 weeks), and the lipid profiles were measured at the same time. Patients were divided into groups based on quartiles of HOMA‐IR. The information on pregnancy outcomes and risk factors was extracted from the medical records of all participants and entered electronically. Logistic regression models were used to analyze the associations between HOMA‐IR and pregnancy outcomes, as well as the associations between risk factors and HOMA‐IR.ResultsGreater IR was associated with cesarean delivery, preterm delivery, macrosomia, and large for gestational age newborns, but only significantly associated with preterm delivery after adjustment for potential confounders (P < .001). Prepregnancy body mass index (BMI), weight gain before diagnosis of GDM, and triglycerides were significantly related with IR in the late second trimester (P < .001). Besides, the total area under the curve of the diagnostic 75‐g oral glucose tolerance test and glycosylated hemoglobin A1c increased from the lowest to the highest HOMA‐IR groups.ConclusionsIncreasing IR in the late second trimester predicts adverse pregnancy outcomes especially for preterm delivery in women with GDM. Additionally, prepregnancy BMI and weight gain before diagnosis of GDM are independent risk factors for the development of IR.
A Systematic review and Meta‐Analysis of the survival and clinicopathological features of p63 expression in Merkel cell carcinoma
Authors: Portilla Nataly , Alzate Juan P. , Sierra Fabio A. , Parra‐Medina Rafael 
Published: December 2019

AbstractMerkel cell carcinoma (MCC) is a rare skin tumour of neuroendocrine origin with aggressive behaviour. The aims of this study were to investigate the association of p63 + MCC with clinicopathological features and to estimate survival through a systematic review and meta‐analysis. A comprehensive search of PubMed, Embase, Scopus and Virtual Health Library following the PRISMA guidelines was conducted on September 2017. DerSimonian and Lard random‐effects models were used to calculate survival‐weighted means and their corresponding 95% confidence intervals (CI) among studies. Five studies met our inclusion criteria after screening 77 citations and 36 full‐text articles. The included studies enrolled 413 patients with MCC. We observed that p63 + MCC was significantly associated with mortality with OR 2.92 (95% CI [1.66–5.13]). The summary hazard ratio of multivariate analysis was 1.99 (95% CI [1.32–3.01]). The only clinicopathological feature associated with p63 + MCC with statistical significance was the Merkel cell polyomavirus (MCPyV) status. The presence of MCPyV was associated as a protective factor for the expression of p63 (OR 0.25, 95% CI [0.08–0.73]). These results support that p63 + MCC evaluated by immunohistochemistry has a poor outcome. Therefore, we suggest p63 to be performed when staging MCC.
Access to Schlemm's canal for canaloplasty: an intra‐individual comparison of two dissection techniques
Authors: Grieshaber Matthias C. , Pienaar Ané , Stegmann Robert 
Published: December 2019

AbstractPurposeTo compare a modified incision technique with classic scleral flap dissection for canaloplasty with canal expander regarding efficacy and safety.MethodsIn a prospective randomized pilot study of 32 eyes of 16 patients with primary open‐angle glaucoma, access to Schlemm's canal was created by deep lamellar dissection (scleral flap excision, group 1) or by vertical cut‐down incision (group 2). Following canal opening and viscodilation with microcannula and sodium hyaluronate, two Stegmann Canal Expanders were implanted, and the scleral flap or vertical incision, respectively, was closed watertight.ResultsMean preoperative intraocular pressure (IOP) was 34.9 mmHg ± 6.7 [standard deviation (SD)] in group 1 and 33.8 mmHg ± 7.7 (SD) in group 2 (p = 0.66); mean postoperative IOP without medications was 14.3 mmHg ± 2.9 (SD) in group 1 and 14.8 mmHg ± 5.2 (SD) in group 2 at 1 month (p = 0.76), and 14.4 mmHg ± 1.9 (SD) in group 1 and 16.8 mmHg ± 3.1 (SD) in group 2 at 12 months (p = 0.01). Overall, there was a significant preoperative–postoperative IOP difference between groups (19.4 mmHg ± 10.1, group 1; 16.6 mmHg ± 8.9, group 2; p = 0.02). Surgery type had a significant effect when adjusted for preoperative IOP, cup–disc ratio, eye side, follow‐up number and surgery type (p < 0.01, anova). No filtering bleb was observed in either group. Intra‐ and postoperative complications were rare and included peripheral Descemet's membrane detachment (3), microhyphema (2) and cannulation into the anterior chamber (1).ConclusionsIn this intra‐individual comparative study of ab externo canaloplasty with the canal expander, IOP reduction was substantial in both groups and slightly greater in the group with deep scleral flap excision. Additional IOP reduction by transscleral drainage through the Descemet's membrane window and intrascleral lake is suggested.
Genome‐wide re‐sequencing and transcriptome analysis reveal candidate genes associated with the pendulous comb phenotype in domestic chickens
Authors: Guo Xing , Wang Jiangxian , Ma Chendong , Wang Zhicheng , Chen Hong , Su Hu , Wan Yi , Jiang Runshen 
Published: December 2019

AbstractTo determine the causative variations associated with two chicken comb phenotypes, pendulous comb (PC) or upright comb (UC), two pooled genomic DNA samples from PC and UC chickens were re‐sequenced by Next‐Generation Sequencer, and genome‐wide Single nucleotide polymorphisms (SNPs) were detected. Using three selective sweep approaches, FST, θπ, and Tajima's D, with top 5% window values serving as the threshold, a total of 84 positively selective genes (PSGs) were identified. There were no SNPs in exons of the PSGs with significant differences in allele frequencies between the two comb phenotype groups. Then, 515 differentially expressed genes (DEGs) between the PC and UC were identified by RNA‐seq. Three genes including CD36 (CD36 molecule), ADAMTSL3 (ADAMTS‐like 3), and AOX1 (aldehyde oxidases 1) are overlapped between PSGs and DEGs. After genotyping seven candidate SNPs in the regulatory regions of the three overlapping genes in 120 chickens from two other breeds, two variants (rs14607046 and rs731818051) in the regulatory regions of AOX1 and ADAMTSL3 were found to have significant differences in allele frequency between the PC and UC, suggesting that the two variants may be causative mutations for PC. Overall, our study shed light on the genetic basis underlying the PC phenotype in chickens.
Racial/ethnic differences in treatment quality among youth with primary care provider‐initiated versus mental health specialist‐initiated care for major depressive disorders
Authors: Yucel Aylin , Sanyal Swarnava , Essien Ekere J. , Mgbere Osaro , Aparasu Rajender , Bhatara Vinod S. , Alonzo Joy P. , Chen Hua 
Published: December 2019

ObjectivesTo compare the racial/ethnic differences in treatment quality among youth with primary care provider‐initiated versus mental health specialist‐initiated care for major depressive disorders (MDD).MethodsA retrospective cohort study was conducted using the 2005–2007 Medicaid claims data from Texas. Youth aged 10–20 during the study period were identified if they had two consecutive MDD diagnoses and received either medications for MDD or psychotherapy. Patients who received ≥84 days of medications and/or ≥4 sessions of psychotherapy for MDD treatment during 4 months of follow‐up were considered meeting the minimum adequacy of treatment.ResultsThe generalized linear multilevel model (MLM) analysis revealed that both Hispanics and Blacks were approximately 30% less likely to receive adequate treatment (Hispanics – OR: 0.67; 95% CI: 0.6–0.8) (Blacks – OR: 0.66; 95% CI: 0.6–0.8) and Hispanic children were 50% more likely to undergo MH‐related hospitalization (OR: 1.53; 95% CI: 1.1–2.2) compared to their White counterparts. The odds of meeting the minimum MDD treatment adequacy were comparable between pediatric MDD cases first identified by primary care providers (PCP‐I) and psychiatrists (PSY‐I) (PCP‐I vs. PSY‐I: OR: 0.97; 95% CI: 0.8–1.2), and slightly lower in those first identified by social workers/psychologists (SWP‐I) as compared to PSY‐I (SWP‐I vs. PSY‐I: OR: 0.81; 95% CI: 0.7–0.9). In all models, the interaction between race/ethnicity and type of provider who initiated MDD care was not statistically significant.ConclusionsMinority youths received less adequate MDD treatment compared to Whites. Hispanic children had the highest risk of having mental health‐related hospitalization. The specialty of provider who initiated MDD care had limited impact on treatment quality and was not associated with the racial/ethnic variations in treatment completion and mental health‐related hospitalizations.
Platform‐switched implants vs platform‐matched implants placed in different implant‐abutment interface positions: A prospective randomized clinical and microbiological study
Authors: Uraz Ahu , Isler Sila C. , Cula Serpil , Tunc Samet , Yalim Mehmet , Cetiner Deniz 
Published: December 2019

AbstractBackgroundPlacement of the implant‐abutment interface (IAI) away from the bone crest has been suggested to have positive impacts on maintenance of peri‐implant tissues.PurposeTo assess the effects of platform‐switched and platform‐matched implants, taking into consideration the IAI at different positions relative to the bone crest, on clinical, radiographic, and microbiological outcomes during 12 months following functional loading.Materials and MethodsThe present prospective randomized study was performed upon 70 patients. Group I (n = 23) implants presenting a platform‐switched implant‐abutment connection design was inserted 1 mm subcrestally. Group II (n = 22) implants with similar properties were inserted crestally. Group III (n = 25) implants presenting a platform‐matched approach with an internal hexagon connection design was inserted crestally. The periodontal parameters were assessed at baseline, and 3, 6, and 12 months postloading. Radiographic marginal bone level (MBL) changes were analyzed at the 12‐month follow‐up. The amount of DNA copies of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Provetalla intermedia and total bacterial mean load in peri‐implant sulcus fluid (PISF) were assessed at the same periods.ResultsThere were no significant differences among the groups with respect to the periodontal parameters for all time periods. At 12‐month follow‐up, the MBL changes were 0.16 ± 0.29 mm and 0.17 ± 0.23 mm for group I, 0.15 ± 0.25 mm and 0.17 ± 0.26 mm for group II, 0.17 ± 0.26 mm and for group III in mesial and distal sites, respectively. The mean total bacterial load was found significantly higher for group III compared to the other groups in the three interval times (P < .05).ConclusionImplants restored with platform‐switching and platform‐matching performed equally regarding clinical and radiographic outcomes. Platform‐matched implants inserted at the crestal level presented higher the mean bacterial total load in PISF.
Response to bronchodilator and clinical, pathophysiological features in patients with nonasthmatic eosinophilic bronchitis
Authors: Lai Kefang , Yi Fang , Han Lina , Liu Baojuan , Zhang Xu , Xue Yongxin , Luo Wei , Chen Qiaoli 
Published: December 2019

AbstractIntroductionWhether nonasthmatic eosinophilic bronchitis (NAEB) shows response to bronchodilator (RB) remains unclear.ObjectivesTo investigate the RB and its relationship with clinical and pathophysiological features in NAEB.MethodsFifty‐one patients with NAEB were assigned in a 2:1 ratio to receive oral bambuterol hydrochloride (n = 34, 10 mg, once daily, for 3 days) or matched placebo (n = 17) randomly, of whom 48 patients (32 with bronchodilator and 16 with placebo) completed the study. Sputum induction, spirometry and cough reflex sensitivity were measured. RB was considered when cough Visual analogue scale (VAS) score decreased 30% or more after treatment. Cough reflex sensitivity was defined as the lowest concentration of capsaicin inducing five coughings or more (C5), and presented as Log C5.ResultsThe responsive rate of patients with bronchodilator was significantly higher than that with placebo (34.4% vs 6.3%, P < 0.05). The VAS score decreased significantly in patients with bronchodilator (median: 6.0‐3.0, P < 0.01). There was a significantly higher median Log C5 (2.7 vs 1.3, P < 0.05), and a higher trend of decline in FEV1% predicted and MMEF% predicted after bronchial provocation in patients with RB as compared with patients without RB. No significant differences in baseline percentages of sputum eosinophil were found between patients with RB and that without RB.ConclusionsOne third of patients with NAEB respond well to bronchodilator treatment, which are related with lower cough reflex sensitivity and increased airway responsiveness. The relationship between NAEB and asthma needs to be investigated further.
Liver, simultaneous liver‐kidney, and kidney transplantation from hepatitis C‐positive donors in hepatitis C‐negative recipients: A single‐center study
Authors: Crismale James F. , Khalid Mian , Bhansali Arjun , De Boccardo Graciela , Khaim Rafael , Florman Sander S. , Shapiro Ron , Schiano Thomas D. 
Published: December 2019

AbstractTransplantation of organs from hepatitis C virus (HCV)‐antibody (Ab) and ‐nucleic acid test (NAT) positive donors into HCV‐negative recipients has been proposed to expand the donor pool and shorten waiting times. Data on early single‐center outcomes are lacking. Nineteen liver (LT, including seven simultaneous liver‐kidney [SLKT]) and 17 kidney transplant (KT) recipients received organs from HCV (+) donors; of these, 13 were HCV NAT (+) in each group. All patients who received organs from HCV NAT (+) donors developed HCV viremia post‐transplant except for 2 KT recipients. Patients were treated with a variety of direct‐acting antiviral regimens, with high rates of sustained virologic response among those with at least 12 weeks of follow‐up past the end of treatment: 12/13 (92%) and 8/8 (100%) among LT/SLKT, and KT recipients. Median time to treatment start was 42 days (interquartile range [IQR] 35‐118 days) and 40 days (IQR 26‐73) post‐LT/SLKT and KT, respectively. One death occurred in a SLKT recipient unrelated to HCV or its treatment. There was no significant increase in rejection, proteinuria, or changes in immunosuppression in any group. Organs from HCV‐viremic donors can be utilized for HCV‐uninfected recipients with good short‐term outcomes.
MGMT promoter methylation is a rare epigenetic change in malignant effusions
Authors: Brunetti Marta , Panagopoulos Ioannis , Micci Francesca , Davidson Ben 
Published: December 2019

AbstractObjectiveThe aim of this study was to analyse the promoter methylation status of the gene O6‐methylguanine‐DNA methyltransferase (MGMT) in malignant effusions, with focus on serous carcinoma.MethodsFresh‐frozen cell pellets from 81 effusions (42 peritoneal, 38 pleural, one pericardial), consisting of 71 carcinomas of different origin (33 ovarian, 23 breast, six lung, five uterine corpus and four cervical carcinomas) and 10 malignant mesotheliomas, were analysed for MGMT methylation using pyrosequencing analysis.ResultsMGMT methylation at all four cytosine‐guanine dinucleotide sites examined was detected in only 2/81 (2%) specimens, consisting of a high‐grade serous carcinoma with high frequency of methylation, and a breast carcinoma with low methylation frequency.ConclusionThe findings in the present study suggest that MGMT methylation is a rare epigenetic change in malignant effusions of different origin.
Assessing competency for remote telecytology rapid on‐site evaluation using pre‐recorded dynamic video streaming
Authors: Monaco Sara E. , Han Min , Dietz Robin , Xing Juan , Cuda Jacqueline , Pantanowitz Liron 
Published: December 2019

AbstractIntroductionTelecytology using real‐time microscopy has gained popularity for rapid on‐site evaluations (ROSE). Although proficiency testing is routinely used in cytopathology, no established means of competency assessment is currently available for telecytology. Our aim was to determine the feasibility of a dynamic (real‐time) platform to assess telecytology competency.MethodsRemote Medical Technology dynamic (real‐time) video streaming platform for ROSE is used at our institution, and short video clips of telecytology cases were recorded using Camtasia Studio 8 software during different ROSE sessions. Selected MP4 videos (range 13‐88 seconds, mean 33 seconds), along with clinical histories, were used to build a multiple‐choice question test with one training case and 20 test cases, utilising Tutor (Philips) software to host the web‐based test. The test was voluntary for cytopathologists and cytotechnologists. Answers and feedback from test takers were analysed.ResultsThirteen participants—four cytopathologists and nine cytotechnologists—previously trained to use telecytology, volunteered to take the test. Individual scores ranged from 10 (50%) to 19 (95%) with a median of 16 (80%). Most feedback received involved technical difficulties.ConclusionsWe present, to the best of our knowledge, the first tool to assess telecytology competency for ROSE using pre‐recorded dynamic streaming videos. Despite technical challenges related to incorporating videos into a web‐based test, the test was feasible and provided users with valuable feedback about their ROSE performance. Future effort will be devoted to establishing a more user‐friendly test platform and establishing a benchmark for passing scores.