bluuebunny/crossref_metadata_2025_split huggingface dataset:
The non-Italian Ars Nova: how to read the madrigal Povero zappator by Lorenzo da Firenze
Authors: Abramov-van Rijk Elena 
Published: December 2019

Abstract
The label ‘Ars Nova’ is not easily applicable to Italian 14th-century music, since its main characteristics, such as isorhythm, diminution, pre-existing tenors, and so on, are practically absent, with a few exceptions, from Italian musical compositions, even Italian motets. Yet, isorhythm and diminution were used in the madrigal Povero zappator by Lorenzo da Firenze. What was the reason for using these devices just in this madrigal, whose poetic text about a lone sailor in a tempestuous sea at first glance seems to be a poem typical of Trecento madrigals? This article contends that this text, which so far has attracted little scholarly attention, is derived from Petrarch’s canzone Ne la stagion che ’l ciel rapido inchina. This provides not only a clue to understanding Lorenzo’s intentions, but, in a larger perspective, it also discloses the perception by Italian Trecento musicians of the musical thinking of their transalpine colleagues.
Compounding Complexity: Examining Multiple Factors Leading to Challenges Within Grandfamilies
Authors: Tompkins Catherine J , Vander Linden Kara 
Published: December 2019

AbstractBackground and ObjectivesGrandparents who are raising their grandchildren in the absence of the biological parents, often referred to as custodial grandparents, are prevalent across the United States. The objective of this project was to establish a grounded theory as a tool for practitioners and researchers to understand the experiences of members of grandfamiles.Research Design and MethodsIn-depth, unstructured interviews with custodial grandparents and grandchildren from 15 grandfamilies were conducted. Classic grounded theory was the methodology used to ask the question, “What are the challenges within grandfamilies and how do they respond to these challenges?”ResultsThe theory emerging from the data, Compounding Complexity, provides an explanatory framework of three interrelated categories of factors that affect complexity in grandfamilies: situational, relationship, and emotional complexity. Conflict and change were found to be consistent across the categories of Compounding Complexity.Discussions and ImplicationsNext steps include adding data from interviews with biological parents to Compounding Complexity and applying the theory. Understanding relationship, situational, and emotional complexity in the context of conflict and change enables practitioners to advance their work with grandfamiies.
From surface seismic data to reservoir elastic parameters using a full-wavefield redatuming approach
Authors: Garg Aayush , Verschuur D J 
Published: December 2019

SUMMARY
Traditionally, reservoir elastic parameters inversion suffers from the overburden multiple scattering and transmission imprint in the local input data used for the target-oriented inversion. In this paper, we present a full-wavefield approach, called reservoir-oriented joint migration inversion (JMI-res), to estimate the high-resolution reservoir elastic parameters from surface seismic data. As a first step in JMI-res, we reconstruct the fully redatumed data (local impulse responses) at a suitable depth above the reservoir from the surface seismic data, while correctly accounting for the overburden interal multiples and transmission losses. Next, we apply a localized elastic full waveform inversion on the estimated impulse responses to get the elastic parameters. We show that JMI-res thus provides much more reliable local target impulse responses, thus yielding high-resolution elastic parameters, compared to a standard redatuming procedure based on time reversal of data. Moreover, by using this kind of approach we avoid the need to apply a full elastic full waveform inversion-type process for the whole subsurface, as within JMI-res elastic full waveform inversion is only restricted to the reservoir target domain.
Have you got the time? Challenges using vendor electronic health record metrics of provider efficiency
Authors: Hron Jonathan D , Lourie Eli 
Published: December 2019

AbstractThe rise of clinician burnout has been correlated with the increased adoption of electronic health records (EHRs). Some vendors have used data entry logs to measure the amount of time spent using the EHR and have developed metrics of provider efficiency. Initial attempts to utilize these data have proven difficult as it is not always apparent whether variations reflect provider behavior or simply the metric definitions. Metric definitions are also updated intermittently without warning, making longitudinal assessment problematic. Because the metrics are based on proprietary algorithms, they are impossible to validate without costly time–motion studies and are also difficult to compare across institutions and vendors. Clinical informaticians must partner with vendors in order to develop industry standards of EHR use, which could then be used to examine the impact of EHRs on clinician burnout.
Expression of FOXP3 in Canine Gliomas: Immunohistochemical Study of Tumor-Infiltrating Regulatory Lymphocytes
Authors: Pi Castro Dolors , José-López Roberto , Fernández Flores Francisco , Rabanal Prados Rosa M , Mandara Maria Teresa , Arús Carles , Pumarola Batlle Martí 
Published: December 2019

Abstract
Dogs develop gliomas with similar histopathological features to human gliomas and share with them the limited success of current therapeutic regimens such as surgery and radiation. The tumor microenvironment in gliomas is influenced by immune cell infiltrates. The present study aims to immunohistochemically characterize the tumor-infiltrating lymphocyte (TIL) population of naturally occurring canine gliomas, focusing on the expression of Forkhead box P3-positive (FOXP3+) regulatory T-cells (Tregs). Forty-three canine gliomas were evaluated immunohistochemically for the presence of CD3+, FOXP3+, and CD20+ TILs. In low-grade gliomas, CD3+ TILs were found exclusively within the tumor tissue. In high-grade gliomas, they were present in significantly higher numbers throughout the tumor and in the brain-tumor junction. CD20+ TILs were rarely found in comparison to CD3+ TILs. FOXP3+ TILs shared a similar distribution with CD3+ TILs. The accumulation of FOXP3+ Tregs within the tumor was more pronounced in astrocytic gliomas than in tumors of oligodendroglial lineage and the difference in expression was significant when comparing low-grade oligodendrogliomas and high-grade astrocytomas. Only high-grade astrocytomas presented FOXP3+ cells with tumoral morphology. In spontaneous canine gliomas, TILs display similar characteristics (density and distribution) as described for human gliomas, supporting the use of the dog as an animal model for translational immunotherapeutic studies.
BAT AGN Spectroscopic Survey – XIX. Type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows
Authors: Rojas A F , Sani E , Gavignaud I , Ricci C , Lamperti I , Koss M , Trakhtenbrot B , Schawinski K , Oh K , Bauer F E , Bischetti M , Boissay-Malaquin R , Bongiorno A , Harrison F , Kakkad D , Masetti N , Ricci F , Shimizu T , Stalevski M , Stern D , Vietri G 
Published: December 2019

ABSTRACT
We present a detailed study of ionized outflows in a large sample of ∼650 hard X-ray-detected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [O iii] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z ∼0.05). We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass ($\rm \mathit{ M}_{BH}$), gas column density ($\rm \mathit{ N}_{H}$), Eddington ratio ($\rm \lambda _{Edd}$), [O iii], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [O iii] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios [log($\rm \lambda _{Edd}$) ≳ −1.7]. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature.
Multiband optical flux density and polarization microvariability study of optically bright blazars
Authors: Pasierb Magdalena , Goyal Arti , Ostrowski Michał , Stawarz Łukasz , Wiita Paul J , Gopal-Krishna  , Larionov Valeri M , Morozova Daria A , Itoh Ryosuke , Alicavus Fahri , Erdem Ahmet , Joshi Santosh , Zola Staszek , Borman Georgy A , Grishina Tatiana S , Kopatskaya Evgenia N , Larionova Elena G , Savchenko Sergey S , Nikiforova Anna A , Troitskaya Yulia V , Troitsky Ivan S , Akitaya Hiroshi , Kawabata Miho , Nakaoka Tatsuya 
Published: December 2019

ABSTRACT
We present the results of flux density, spectral index, and polarization intra-night monitoring studies of a sample of eight optically bright blazars, carried out by employing several small to moderate aperture (0.4 to 1.5 m diameter) telescopes fitted with CCDs and polarimeters located in Europe, India, and Japan. The duty cycle of flux variability for the targets is found to be ∼45 per cent, similar to that reported in earlier studies. The computed two-point spectral indices are found to be between 0.65 to 1.87 for our sample, comprised of low- and intermediate-frequency peaked blazars, with one exception: they are also found to be statistically variable for about half the instances where ‘confirmed’ variability is detected in flux density. In the analysis of the spectral evolution of the targets on hourly time-scale, a counterclockwise loop (soft-lagging) is noted in the flux–spectral index plane on two occasions, and in one case a clear spectral flattening with the decreasing flux is observed. In our data set, we also observe a variety of flux–polarization degree variability patterns, including instances with a relatively straightforward anticorrelation, correlation, or counterclockwise looping. These changes are typically reflected in the flux–polarization angle plane: the anticorrelation between the flux and polarization degree is accompanied by an anticorrelation between the polarization angle and flux, while the counterclockwise flux–PD looping behaviour is accompanied by a clockwise looping in the flux–polarization angle representation. We discuss our findings in the framework of the internal shock scenario for blazar sources.
‘Our Fellow Shakespeare’: A Contemporary Classic in the Early Modern University
Authors: Blank Daniel 
Published: December 2019

Abstract
This essay discusses the reception of Shakespeare’s works among the students and fellows of early modern Oxford and Cambridge. Taken at face value, the documentary record would seem to suggest that Shakespeare had no place there, as authorities at the two English universities aimed to prevent the presence of his work in the academic sphere. However, this essay uses a variety of literary and archival evidence to show that Shakespeare’s works not only entered into scholarly discourse, but also achieved a status that had previously been reserved for ancient authors. I argue that the best window into Shakespeare’s reception among early modern scholars can be found in academic drama, and I examine two university theatrical productions that engage closely with his works: the Parnassus plays, performed at Cambridge between 1598 and 1601, and Narcissus, performed at Oxford in 1602. These plays not only provide early examples of Shakespeare’s reception among intellectuals, but also illustrate how the scholars of Oxford and Cambridge figured Shakespeare as a ‘classical’ author—an author as worthy of imitation as Homer or Ovid. The process of establishing Shakespeare as a ‘classic’ in the academic setting, this essay ultimately argues, began much earlier than scholars have realized.
Mass Casualty Incident Simulation for a Small Space With Limited Resources
Authors: Screws Sarah , Cason Melanie 
Published: December 2019

Abstract
To be able to respond appropriately and safely, nursing students must learn about the principles of triage and managing disasters. An accelerated bachelor of science in nursing program with limited resources (space and time) determined there was a need for education on these principles beyond the classroom and developed a mass casualty incident simulation for a small space and budget. Based on faculty and student evaluation, this activity was found to be effective in presenting and enhancing understanding of the principles for triage and disaster management as they relate to nursing.
Addressing the impact of ethnicity on asthma care
Authors: Tay Tunn Ren , Pham Jonathan , Hew Mark 
Published: December 2019

Purpose of review
In asthma, there is an increasing focus on personalizing treatment by targeting treatable traits. Ethnicity has effects on many biological and behavioural traits, and so is an important consideration when personalizing asthma care. This review has particular relevance in light of current patterns of international migration, which are leading to unprecedented levels of ethnic heterogeneity in many geographic regions.

Recent findings
This review examines the effect of ethnicity on three key domains – biological traits, behavioural traits and health system behaviour. Ethnicity influences asthma biology by affecting biomarker reference ranges, response to drug therapy and asthma phenotypes. Ethnicity impacts behavioural traits through its effects on psychosocial well being, adherence and asthma self-management. Ethnic minorities are often disadvantaged with regards to healthcare access and healthcare interactions.

Summary
Concerted action is needed to address current issues around behavioural traits and healthcare behaviour, which are influenced by ethnicity. More research is required to understand the impact of ethnicity on asthma biology, especially the interplay between genetic and environmental influences on asthma, and the differential response to asthma therapies.
Febrile Hashimoto's encephalopathy associated with Graves’ disease and acute pancytopenia
Authors: Liu Shaoyu , Ma Qingbian , Zheng Yaan 
Published: December 2019

Abstract

Rationale:
Hashimoto's encephalopathy (HE) is an autoimmune-mediated encephalopathy rarely seen in Graves’ disease, with <20 cases reported previously, associated with elevated concentration of circulating serum anti-thyroid antibodies usually responsive to steroid therapy.

Patient concerns:
We present a HE case (25-year-old male) with Graves’ disease, complicated by fever and pancytopenia. The patient presented with fever, gait impairment, delirium, agitation and disorientation.

Diagnoses:
Thyroid-related antibodies were elevated and brain magnetic resonance imaging confirmed symmetrical white-matter lesion. There was no evidence of infection or other reasons to explain all of his clinical manifestations. Hashimoto's encephalopathy (HE) is an autoimmune encephalopathy with various manifestations and the characteristic of elevated anti-thyroid antibodies and has no relationship to thyroid function.

Interventions:
The patient had nonspecific clinical manifestations and excellently respond to glucocorticoid therapy.
The symptoms and the radiographic abnormalities disappeared after glucocorticoid therapy.

Outcomes:
We followed up with him for 5 years, in which there was no recurrence and his thyroid function continued to be normal.

Lessons:
It is important to evaluate thyroid function and related antibodies in patients present with neuropsychological symptoms to avoid delay in diagnosis.
Heterogeneous response to target therapy in metastatic papillary renal cell carcinoma evaluated by morphologic and metabolic multimodality imaging
Authors: Naglieri Emanuele , Niccoli Asabella Artor , Nappi Anna Giulia , Carella Claudia , Ferrari Cristina , Rubini Giuseppe 
Published: December 2019

Abstract

Rationale:
Papillary renal cell carcinoma (PRCC) accounts for about 15% to 20% of renal cell carcinoma and is histologically distinguished in type I and type II. The last one is associated with poorer prognosis.
Treatment options for PRCC patients are surgery, immunotherapy, revolutionized by Nivolumab, and other target-therapy with an improvement in overall survival. Heterogenous response and a pseudo-progression may be observed in the initial phase of biological treatment that could induce premature discontinuation.

Patient concerns:
We present the case of a 44-year-old woman with left cervical palpable mass increased in size and without concomitant disease or previous surgery.

Diagnosis:
Neck ultrasonography, contrast-enhanced Computed Tomography, and 18F-FDG PET/CT were performed with the detection of lymph nodes involvement and a left renal lesion.

Interventions:
The patients underwent left radical nephrectomy and homolateral cervical and para-aortic lymphadenectomy, with histological diagnosis of PRCC, type II. After disease relapse, the inter-aortocaval lymph node was laparoscopically removed. Following the detection of further disease relapse in several lymph nodes and the lung, several lines of target-therapy were started; then disease progression and worsening of clinical and hematological status led us to start Nivolumab as last-line therapy.

Outcomes:
A heterogeneous response to therapies was documented with morphological and nuclear medicine imaging, however the concomitant deterioration of performance status and liver function led to discontinuation of Nivolumab; then the patient died, 30 months after diagnosis.

Lessons:
Here we describe the clinical case and radiological and nuclear medicine imaging investigations performed by our patient, highlighting that 18F-FDG PET/CT shows greater adequacy in assessing the response to therapy, avoiding premature drug discontinuation, and ensuring better management of a patient with advanced PRCC.
The effect of additional transforaminal epidural blocks on percutaneous epidural neuroplasty with a wire-type catheter
Authors: Gil Ho Young , Lee Sook Young , Min Sang Kee , Kim Ji Eun , Lee Hye Seon , Jeong Hae Won , Park Bumhee , Choung Jinhee , Choi Jong Bum 
Published: December 2019

Abstract
Percutaneous epidural neuroplasty (PEN) is an effective interventional treatment for radicular pain. However, in some cases, contrast runoff to the spinal nerve root does not occur. We investigated whether contrast runoff to the spinal nerve root affects the success rate of PEN and whether additional transforaminal epidural blocks for intentional contrast runoff affect the success rate of PEN in cases in which contrast runoff is absent.
This study was registered at ClinicalTrials.gov (Identifier: NCT03867630) in March 2019. We reviewed the medical records of 112 patients who underwent PEN with a wire-type catheter from May 2016 to August 2018. Patients were divided in 3 groups (Runoff group, Non-runoff group, Transforaminal group).
Patients with low back pain and leg radicular pain who did not respond to lumbar epidural steroid injections
PEN was performed in 112 patients with a wire-type catheter in target segment. We compared the success rate of PEN between
The success rate was significantly different between the Runoff group and the Non-runoff group (P < .0007) and between the Non-runoff group and the Transforaminal group (P = .0047), but not between the Runoff group and the Transforaminal group (P = .57).
Contrast runoff influenced the success rate of PEN. In cases without contrast runoff, additional transforaminal epidural blocks for intentional contrast runoff increased the success rate of PEN with a wire-type catheter.
Compressive myelopathy and compression fracture of aggressive vertebral hemangioma after parturition
Authors: Wang Guan-xi , Mu Yuan-dong , Che Jun-yi , Zhang Guang-fei , Jiang Gang , Gao Chuan-ping 
Published: December 2019

Abstract

Rationale:
Compressive myelopathy and compression fracture of aggressive vertebral hemangioma after parturition is a rare condition. Vertebral body compression fracture and high serum progesterone lead to extraosseous hemangioma enlargment cause narrowing the spinal canal which contribute to compressive myelopathy relate to pregnancy.

Patient concerns:
We report a case of compressive myelopathy and compression fracture of aggressive vertebral hemangioma after parturition in a 35-year-old woman. The patient complained unable to walk and experienced intense pain in the back.

Diagnosis:
Based on the clinical features and imaging studies, the patient underwent a T4–T6 laminectomy. Histopathology consistent with vertebral hemangioma.

Interventions:
The patient underwent laminectomy for decompression. After subperiosteal dissection of the paraspinal muscles and exposure of the laminae, there was no involvement of the lamina by the tumor. The epidural tumor was removed through the spaces lateral to the thecal sac. Vertebroplasty was performed through T5 pedicles bilaterally and 7 ml of polymethylmethacrylate (PMMA) cement was injected. T4–T6 pedicle screw fixation was performed for segmental fixation and fusion.

Outcomes:
Six months after resection of the tumor the patient remained asymptomatic. She reported no low back pain and had returned to her normal daily activities, with no radiographic evidence of recurrence on MRI. Physical examination revealed that superficial and deep sensation was restored to normal levels in the lower extremities.

Lessons:
The occurrence of compressive myelopathy of pregnancy related vertebral hemangiomas is quite unusual. It can lead to serious neurologic deficits if not treated immediately. So, prompt diagnosis is important in planning optimal therapy and preventing morbidity for patients.
Combined albumin-bilirubin grade and Mac-2 binding protein glycosylation isomer as a useful predictor in compensated liver cirrhosis
Authors: Nishikawa Hiroki , Enomoto Hirayuki , Yoh Kazunori , Iwata Yoshinori , Sakai Yoshiyuki , Kishino Kyohei , Ikeda Naoto , Takashima Tomoyuki , Aizawa Nobuhiro , Takata Ryo , Hasegawa Kunihiro , Ishii Noriko , Yuri Yukihisa , Nishimura Takashi , Iijima Hiroko , Nishiguchi Shuhei 
Published: December 2019

Abstract
We aimed to compare the impact on survival among albumin-bilirubin (ALBI) grade, modified ALBI (mALBI) and our proposed combined ALBI grade and Mac-2 binding protein glycosylation isomer (M2BPGi) or FIB4 index grading system in chronic hepatitis C (CHC) related compensated liver cirrhosis (n = 165, 93 men and 72 women, median age = 67 years). Patients with ALBI grade 1, 2, and 3 were allocated a score of 1, 2, and 3 points, respectively. Patients with mALBI grade 1, 2A, and 2B were allocated a score of 1, 2, and 3 points, respectively. Patients with a high or low M2BPGi were allocated a score of 1 and 0 point. Patients with a high or low FIB4 index were allocated a score of 1 and 0 point. Sum of the point of ALBI (1, 2, or 3) and M2BPGi (0 or 1) or FIB4 index (0 or 1) was defined as ALBI-M2BPGi grade or ALBI-FIB4 grade. Prognostic accuracy was compared using the Akaike information criterion (AIC) value and time dependent receiver operating characteristics (ROC) curve analysis. The median follow-up duration was 5.422 years. AIC value for survival by ALBI-M2BPGi grade was the lowest among 4 prognostic models (AIC: 205.731 in ALBI grade, 200.913 in mALBI grade, 189.816 in ALBI-M2BPGi grade, and 204.671 in ALBI-FIB4 grade). All area under the ROC curves of ALBI-M2BPGi grade in each time point were higher than those of ALBI grade, mALBI grade, and ALBI-FIB4 grade. In conclusion, our proposed ALBI-M2BPGi grading system seems to be helpful for estimating prognosis in patients with CHC related compensated LC.