bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room Temperature Al18F Labeling of 2‐Aminomethylpiperidine‐Based Chelators for PET Imaging
Authors: Russelli Lisa , Martinelli Jonathan , De Rose Francesco , Reder Sybille , Herz Michael , Schwaiger Markus , Weber Wolfgang , Tei Lorenzo , D'Alessandria Calogero 
Published: December 2019

AbstractPositron emission tomography (PET) is a non‐invasive molecular imaging technology that is constantly expanding, with a high demand for specific antibody‐derived imaging probes. The use of tracers based on temperature‐sensitive molecules (i. e. Fab, svFab, nanobodies) is increasing and has led us to design a class of chelators based on the structure of 2‐aminomethylpiperidine (AMP) with acetic and/or hydroxybenzyl pendant arms (2‐AMPTA, NHB‐2‐AMPDA, and 2‐AMPDA‐HB), which were investigated as such for {Al18F}2+‐core chelation efficiency. All the compounds were characterized by HPLC‐MS analysis and NMR spectroscopy. The AlF‐18 labeling reactions were performed under various conditions (pH/temperature), and the radiolabeled chelates were purified and characterized by radio‐TLC and radio‐HPLC. The stability of labeled chelates was investigated up to 240 min in human serum (HS), EDTA 5 mM, PBS and 0.9 % NaCl solutions. The in vivo stability of [Al18F(2‐AMPDA‐HB)]− was assessed in healthy nude mice (n=6). Radiochemical yields between 55 % and 81 % were obtained at pH 5 and room temperature. High stability in HS was measured for [Al18F(2‐AMPDA‐HB)]−, with 90 % of F‐18 complexed after 120 min. High stability in vivo, rapid hepatobiliary and renal excretion, with low accumulation of free F‐18 in bones were measured. Thus, this new Al18F‐chelator may have a great impact on immuno‐PET radiopharmacy, by facilitating the development of new fluorine‐18‐labeled heat‐sensitive biomolecules.
Impact of performance status on treatment outcomes: A real‐world study of advanced urothelial cancer treated with immune checkpoint inhibitors
Authors: Khaki Ali Raza , Li Ang , Diamantopoulos Leonidas N. , Bilen Mehmet A. , Santos Victor , Esther John , Morales‐Barrera Rafael , Devitt Michael , Nelson Ariel , Hoimes Christopher J. , Shreck Evan , Assi Hussein , Gartrell Benjamin A. , Sankin Alex , Rodriguez‐Vida Alejo , Lythgoe Mark , Pinato David J. , Drakaki Alexandra , Joshi Monika , Isaacsson Velho Pedro , Hahn Noah , Liu Sandy , Alonso Buznego Lucia , Duran Ignacio , Moses Marcus , Jain Jayanshu , Murgic Jure , Baratam Praneeth , Barata Pedro , Tripathi Abhishek , Zakharia Yousef , Galsky Matthew D. , Sonpavde Guru , Yu Evan Y. , Shankaran Veena , Lyman Gary H. , Grivas Petros 
Published: December 2019

BackgroundImmune checkpoint inhibitors (ICIs) represent an appealing treatment for patients with advanced urothelial cancer (aUC) and a poor performance status (PS). However, the benefit of ICIs for patients with a poor PS remains unknown. It was hypothesized that a poor Eastern Cooperative Oncology Group (ECOG) PS (≥2 vs 0‐1) would correlate with shorter overall survival (OS) in patients receiving ICIs.MethodsIn this retrospective cohort study, clinicopathologic, treatment, and outcome data were collected for patients with aUC who were treated with ICIs at 18 institutions (2013‐2019). The overall response rate (ORR) and OS were compared for patients with an ECOG PS of 0 to 1 and patients with an ECOG PS ≥ 2 at ICI initiation. The association between a new ICI in the last 30 and 90 days of life (DOL) and death location was also tested.ResultsOf the 519 patients treated with ICIs, 395 and 384 were included in OS and ORR analyses, respectively, with 26% and 24% having a PS ≥ 2. OS was higher in those with a PS of 0 to 1 than those with a PS ≥ 2 who were treated in the first line (median, 15.2 vs 7.2 months; hazard ratio [HR], 0.62; P = .01) but not in subsequent lines (median, 9.8 vs 8.2 months; HR, 0.78; P = .27). ORRs were similar for patients with a PS of 0 to 1 and patients with a PS ≥ 2 in both lines. Of the 288 patients who died, 10% and 32% started ICIs in the last 30 and 90 DOL, respectively. ICI initiation in the last 30 DOL was associated with increased odds of death in a hospital (odds ratio, 2.89; P = .04).ConclusionsDespite comparable ORRs, ICIs may not overcome the negative prognostic role of a poor PS, particularly in the first‐line setting, and the initiation of ICIs in the last 30 DOL was associated with hospital death location.
Simple and Eco‐Friendly Fabrication of Electrode Materials and Their Performance in High‐Voltage Lithium‐Ion Batteries
Authors: Barbosa Lucía , Luna‐Lama Fernando , González Peña Yarivith , Caballero Alvaro 
Published: December 2019

AbstractThe huge consumption of rechargeable Li‐ion batteries (LIBs) make it necessary to recover and reuse the different components of spent batteries, thus favoring sustainable development. Graphite is a critical material in the manufacture of the current LIBs so recycling it should be prioritized in the management of spent batteries. In this work, graphite is manually recovered from spent batteries used in smartphones. The impurities from the different components of the batteries are drastically reduced by simple leaching with HCl. This treatment significantly improves the delivered specific capacity, with average values of 300 and 390 mAh g−1 without and with leaching, respectively. To test recycled graphite as an anode material in real cells, it is paired with LiNi0.5Mn1.5O4, the most promising cathode material for high‐voltage batteries. LiCl, produced directly by chlorination of spodumene, is used as the Li source to obtain the spinel sample. The real cell gives satisfactory values for both initial specific capacity (100 mAh g−1) and capacity retention after 100 cycles. These results are comparable to and in some cases even better than those for cells that use commercial graphite and conventional Li sources as primary raw materials. Moreover, the cell shows good performance during the rate capability test; the delivered capacity values decrease smoothly from 73 to 62 mAh g−1 while the rate increases from 0.1 to 1 C.
One‐Pot Synthesis of a Copolymer Micelle Crosslinked Binder with Multiple Lithium‐Ion Diffusion Pathways for Lithium–Sulfur Batteries
Authors: Guo Rongnan , Zhang Shunlong , Wang Jianli , Ying Hangjun , Han Weiqiang 
Published: December 2019

AbstractFast lithium‐ion diffusion is very important to obtain high capacity and excellent cycling stability of lithium–sulfur batteries. In this study, a copolymer micelle crosslinked binder (FNA) for lithium–sulfur batteries was successfully synthesized through a one‐pot environmentally friendly approach. The micelles were used as crosslinkers and carriers for the electrolyte. The FNA binder provided multiple lithium‐ion diffusion pathways to increase the lithium‐ion diffusion, which reduced the polarization of the sulfur cathode during the cycling process. The lithium‐ion diffusion pathways of the FNA were provided by the electrolyte hosted in the micelles, the polyethylene oxide and polypropylene oxide segments, and the carboxylate and sulfonate groups in the FNA. In addition, FNA possesses strong lithium polysulfides adsorption and high adhesion properties. Therefore, the electrode with the FNA binder presented a reversible capacity of 571 mAh g−1 with a capacity fade of 0.032 % after 1000 cycles at a cycling rate of 0.5 C, which is much higher than those of the polyvinylidene fluoride (PVDF) sulfur cathode.
Haftverhalten eines textilbewehrten Mörtels für Porenbeton‐Mauerwerk
Authors: Miccoli Lorenzo , Scotta Roberto , Trutalli Davide , Brandolese Sara , Miliani Alessandro 
Published: December 2019

AbstractThe bond behaviour of a textile reinforced mortar (TRM) applied to autoclaved aerated concrete (AAC) masonry has been evaluated experimentally. The TRM is composed of a glass‐fibre mesh combined with a cementitious mortar and is intended to strengthen AAC masonry walls subjected to out‐of‐plane bending during an earthquake. The main components have been characterized with preliminary tests. Then, pull‐off and shear bond tests have been performed to determine the bonding properties of the TRM applied to the AAC substrate. Three types of AAC blocks have been used, which differ in the bulk density and compressive strength, to evaluate possible variation in the bond strength. The results of the experimental campaign have shown a good performance of the strengthening system. In most cases, the bonding between TRM and masonry was maintained up to tensile failure of the dry textile. As expected, the masonry samples realized using AAC blocks with a higher bulk density showed better performances. The paper presents and discusses main test results, providing background data for future recommendations for the use of the analysed strengthening system in AAC masonry structures.
Combined effects of temperature, salinity, and diet simulating upwelling and nonupwelling seasons alter life‐history characteristics of a tropical invertebrate
Authors: Camargo‐Cely Alejandra , Collin Rachel 
Published: December 2019

AbstractUpwelling is known to affect the ecology and life history of temperate nearshore organisms, and these effects are thought to be mediated by changes in temperature and food supply. However, little information is available for tropical systems. To understand how changes in the intensity of upwelling might impact marine invertebrates, we tested how factorial combinations of temperature, salinity, and phytoplankton availability affected growth and reproduction of a common intertidal snail, Crepidula cf. marginalis. We used temperatures typical of nonupwelling (29°C), moderate (26°C) and severe (23°C) upwelling, salinities typical of nonupwelling (30 ppt) and upwelling (34 ppt) and a good diet (Isochrysis) and a better diet (Isochrysis and Tetraselmis) as a proxy for increased productivity during upwelling. Overall, temperature and diet had consistent effects on body size, with better food and lower temperatures promoting larger size, as well as promoting shorter time to first reproduction. Diet had the largest effects on clutch size, with clutch size increasing with better diet. Temperature had the largest effect on offspring size and the frequency of discarded broods; offspring size decreased with increasing temperature and the frequency of discarded broods also decreased with increasing temperatures. We found no significant 3rd order interactions and few significant strong 2nd order interactions, which have often been found in similar experimental studies using stressful treatments. For this tropical slipper limpet, the effect of higher food and cooler temperatures during upwelling appears to be positive, promoting higher growth rates, larger clutch sizes, and larger offspring size suggesting that both factors likely play an important role underlying reproductive responses to upwelling. Climatic changes, like El Niño, which suppress upwelling in the Bay of Panama, appear likely to negatively impact this species.
Reviewing the role of plant litter inputs to forested wetland ecosystems: leafing through the literature
Authors: Stoler Aaron B. , Relyea Rick A. 
Published: December 2019

AbstractThe input of senescent terrestrial leaf litter into soil and aquatic ecosystems is one of the most massive cyclic subsidies on Earth, particularly within forested ecosystems. For freshwater systems embedded within forests, litter inputs provide a vital source of energy and nutrients that allows greater production than in situ resources can provide. In return, freshwater food webs can provide an enormous amount of material to the terrestrial landscape through biotic respiration, photosynthesis, and organism emergence. Most research concerning this important aquatic‐terrestrial link has focused on lotic ecosystems (i.e., streams and rivers); far less attention has been given to its role in lentic systems (i.e., wetlands and lakes). A focus on small forested wetlands is particularly important, as these systems account for a disproportionate amount of global carbon flux relative to their spatial coverage, and the decomposition of leaf litter is a major contributor. Here, we review six themes: (1) the evidence for the role of leaf litter inputs as an ecologically important subsidy in forested wetlands; (2) the bottom‐up effects of quantitative and qualitative variation in litter inputs; (3) how diversity in litter mixtures can alter ecological functioning; (4) evidence for top‐down consequences of litter inputs through toxic effects on predators and parasites, and the alteration of predator–prey interactions; (5) the relevance of our review to other research fields by considering the role of litter inputs relative to other types of subsidies and environmental gradients (e.g., temperature, canopy cover, and hydrology); and (6) the interaction of litter subsidies with anthropogenic disturbances. We conclude by highlighting several high‐priority research questions and providing suggestions for future research on the role of litter subsidies in freshwater ecosystems.
Tactical departures and strategic arrivals: Divergent effects of climate and weather on caribou spring migrations
Authors: Gurarie Eliezer , Hebblewhite Mark , Joly Kyle , Kelly Allicia P. , Adamczewski Jan , Davidson Sarah C. , Davison Tracy , Gunn Anne , Suitor Michael J. , Fagan William F. , Boelman Natalie 
Published: December 2019

AbstractThe Arctic has been warming rapidly, affecting ecological processes across the region. Caribou and reindeer (Rangifer tarandus) is a keystone Arctic species undergoing declines in many parts of its range, but definitive links between climate and populations remain elusive. The conspicuous and dramatic mass migration of many caribou populations, during which nearly all pregnant females move from wintering ranges to calving grounds shortly before giving birth, may be an important link between climate and caribou populations. The drivers of migration, however, are similarly mysterious. It is unknown, for example, whether caribou respond to immediate phenological cues, anticipate conditions on calving grounds, or are driven by lagged effects related to physical condition. To investigate the drivers of migration, we analyzed movement data from over 1000 individual caribou from seven major herds, spanning 3000 km across Alaska, Yukon, Northwest Territories (NWT), and Nunavut in Canada, from 1995 to 2017. We developed a hierarchical model to estimate migration departure and arrival times, and analyzed these variables against global climate indices and local weather conditions, exploring immediate and lagged effects, as well as snowmelt timing and vegetation indices. We discovered a continent‐wide synchrony in spring migration departure times, driven mainly by large‐scale, ocean‐driven climate indices (Pacific Decadal Oscillation, Arctic Oscillation, and North Atlantic Oscillation). However, we also found that the speed of migration was highly plastic with later migration departure times followed by shorter migration durations. This plasticity made arrival timing independent of departure timing and its respective drivers. Rather, arrival timing depended strongly on weather conditions from the previous summer: cooler and windier summers generally led to earlier arrival at calving grounds the following year. We suggest that maternal body condition, mainly influenced by conditions that limit insect harassment, is a major factor for earlier spring migration arrival timing, and therefore earlier calving and higher survival rates. We place these results in the context of mechanistic links between climate and caribou population dynamics. Long‐term and large‐scale observations of migratory animals can provide insights into the mechanisms by which long‐distance, collective migrants may adapt to dynamic and unpredictable environments.
Timing to temperature: Egg‐laying dates respond to temperature and are under stronger selection at northern latitudes
Authors: Shave Amanda , Garroway Colin J. , Siegrist Joe , Fraser Kevin C. 
Published: December 2019

AbstractGlobal climate change produces spatially variable patterns of environmental change. This could put migratory species at risk as the synchrony between migration timing and suitable breeding conditions could become mismatched. For migratory birds, whether the timing of egg laying is a plastic trait that can vary in response to environmental change has been sparsely studied across regions and systems and thus remains poorly known. We investigated the effects of temperature variability and climate warming on the breeding phenology of purple martins (Progne subis), a long‐distance migratory songbird, using a 20‐yr data set comprised of 28,165 records of nest timing and fledgling success spanning the entire breeding range (25–54° N). We discovered that purple martins lay eggs earlier in warmer springs and fledge more young when they lay earlier. After controlling for spatial patterns in the data with Moran's eigenvector maps, we found that selection favored earlier breeding in most years, particularly at more northern latitudes. However, selection pressure for earlier breeding did not increase over the 20‐yr period, perhaps owing to high variability in temperature across years. Our results therefore demonstrate plasticity in the timing of egg laying in response to temperature variation and climate change over 20 yr across the range of this widely distributed, long‐distance migrant. Whether these plastic responses are common or sufficiently matched to climate change among other declining migratory songbird species should be further investigated.
Innovative and efficient method of robotics for helping the Parkinson's disease patient using IoT in big data analytics
Authors: Sivaparthipan C.B. , Muthu Bala Anand , Manogaran Gunasekaran , Maram Balajee , Sundarasekar Revathi , Krishnamoorthy Sujatha , Hsu Ching‐Hsien , Chandran Karthik 
Published: December 2019

AbstractBig data had accumulated a massive amount of stored data for applications including robotics, internet of things (IoT), and healthcare system. Although the IoT‐based healthcare system plays a vital role in big data industry, in some case, the sensing may be difficult to predict the accurate result. The proposed system with artificial intelligence and IoT for Parkinson's disease can enhance the gait performance tremendously. This research clearly defines the role of robots in Parkinson's disease and how they interact with big data analytics. To process the research scheme, data are collected from big data. Moreover, Laser scanned scheme with piecewise linear Gaussian dynamic time warp machine learning is introduced. In order to scan the path for obstacle and safe place, laser scan system is used. The main role of robot is to predict the walker motion and give physical training to the patient. To predict the walker motion of patient, robot has to walk along with patient since the sensors are fixed in both the patient and the robot. Finally, the performance of proposed methodology is evaluated with existing works.
Authentic Self in Evaluation Consulting: Reflections after 10 Years
Authors: Fierro Rita Sinorita 
Published: December 2019

AbstractThis chapter offers a process and a series of exercises for achieving the authenticity of a brand via authentic leadership based on an independent evaluation consultant's 10‐year evolution. This process weaves together four aspects: authentic self, authentic goals, authentic relationships, and authentic lifestyle. Each aspect is guided by an inquiry question: Who am I? What do I care most about? What work is mine to do in the world? What partnerships are consistent with who I am? What schedule provides the best work/life balance for me? Together, these inquiry questions generate a learning journey for the consultant or the firm that is iterative, from year to year. The learning journey includes: understanding personal preferences, learning one's positionality, investing in one's self‐development and soft skills, finding one's tribe, and learning who is one's ideal client. Over time, these practices of self‐reflection on past, present, and future work can build one's authenticity, creating a strong and sustainable brand, and strong and sustainable life for the firm's leaders and workers.
Growing and Nurturing Your Evaluation Business When Your Independent Consultancy Becomes an Employer
Authors: Moses Leah Goldstein 
Published: December 2019

AbstractLessons learned from 19 years building an evaluation consulting business can inform other business owners. The Improve Group has grown from a one‐woman consultancy to an employer of more than thirty people. Staying grounded in a mission and a clear set of values is a guiding principle that has guided and informed growth. Sharing power with staff—to operate democratically while also leveraging their great ideas—has also strengthened The Improve Group's evaluation practice and operations as an organization. Balancing short‐ and long‐term opportunities has helped the organization stay nimble and situate itself well for the future. Reflections on major organizational changes—including a team restructure and the addition of a more inclusive approach to evaluation—show the application of these guiding principles. Additional personal reflections on leadership shed light on what founder and CEO Leah Goldstein Moses has learned about her leadership style over nearly 20 years at the helm of The Improve Group.
Standing on the Shoulders of Giants: Applying Business Management Approaches to Independent Evaluation Consulting
Authors: Feldmann Matthew L. 
Published: December 2019

AbstractIndependent evaluation consultants frequently discuss “how‐to” strategies to determine ways to start or improve their practices. Mostly this involves sharing advice on a range of topics such as how and when to set up a corporate structure, what accounting software to use, how to develop new business, and where to work. Such advice also should include information about business theory that more broadly orients consultants to business planning. This movement, from the “how” to the “why,” is imperative for long‐term business success. This chapter introduces three widely accepted business books that cover niche identification, market focus, business development, smart business growth, and the importance of generosity with networking. The reader is oriented to these concepts through Amy, a fictitious, introverted independent evaluation consultant, and her new consulting practice, EduEval USA. Amy demonstrates how to identify appropriate goals and her niche market, develops a marketing approach that is appropriate for a service consultancy, and begins networking with other evaluators and educators in her community.
Branding for the Independent Consultant: Basic to Advanced
Authors: Evergreen Stephanie , Sabarre Nina 
Published: December 2019

AbstractWith a growing contingency of evaluators consulting in the gig economy, questions have shifted from “Should I?” to “How do I?” This chapter provides tips and strategies for branding your business as an independent consultant. Branding has become increasingly important for independent consultants, as a way to tell the world who you are and the unique value you offer. For new consultants, branding is a means for potential clients to find and remember you, and for you to showcase your skills and competencies. For established consultants or businesses, branding can be a catalyst to land bigger (as in, higher profile or larger) and better (as in, more lucrative, connected, or longer‐term) clients. This chapter delves into three hypothetical case studies of evaluation consultants, Jason, Siobhan, and Anuj, to provide insight into how branding, and different levels of branding, can help them attract the types of clients they desire. Examples of exemplar branding from established evaluation companies are also shared throughout the chapter.