bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial experiences with a novel biodegradable device for percutaneous closure of atrial septal defects: From preclinical study to first‐in‐human experience
Authors: Li Yi‐Fan , Xie Yu‐Mei , Chen Jun , Li Bo‐Ning , Xie Zhao‐Feng , Wang Shu‐Shui , Zhang Zhi‐Wei 
Published: November 2019

AbstractObjectiveTo evaluate the feasibility, safety, and effectiveness of a novel, absorbable atrial septal defect (ASD) closure device made of poly‐l‐lactic acid (PLLA) in a swine model of ASD and for the first time in humans.MethodsA preclinical safety study was conducted using a swine model of ASD. In a clinical setting, five pediatric patients underwent ASD closure with the PLLA device with fluoroscopic and transthoracic echocardiography guidance. The procedural results and clinical outcomes at 1 day, 30 days, 3 months, and 6 months after closure were analyzed.ResultsThe 24‐ and 36‐month follow‐up results of the preclinical study demonstrated that the PLLA device exhibited good endothelialization and degradability in the swine model. In the clinical study, successful device implantation was achieved in all five patients (median age, 3.6 years; range, 3.1–6.5 years). The mean defect size was (13.6 ± 2.7) mm. Follow‐up at 30 days, 3 months, and 6 months was completed in all five cases. The complete defect closure rates with no residual shunt at 30 days, 3 months, and 6 months follow‐up were 60% (3/5), 80% (4/5), and 80% (4/5), respectively. No device dislodgement, significant aortic valve or mitral valve regurgitation, new onset cardiac arrhythmia, or other adverse events were reported.ConclusionThe study results demonstrated that it is feasible to implant the PLLA device for closure of small to medium sized ASDs without significant residual shunts or severe adverse events in humans. The PLLA device exhibited good endothelialization and degradability in the swine model at 24 and 36 months. Further studies to evaluate long‐term safety and effectiveness with the device in a large cohort of patients are warranted.
Knot my problem: Overcoming transradial catheter complications
Authors: Walker Melanie , Levitt Michael R. , Ghodke Basavaraj V. 
Published: November 2019

AbstractNot all complications from transradial access can be prevented, even with diligent patient selection and preprocedure planning. This brief visual report offers technical suggestions to reverse knots and kinks encountered during catheter manipulation for endovascular transradial cerebral procedures.
Effect of Gold Particles Size over Au/C Catalyst Selectivity in HMF Oxidation Reaction
Authors: Megías‐Sayago Cristina , Lolli Alice , Bonincontro Danilo , Penkova Anna , Albonetti Stefania , Cavani Fabrizio , Odriozola José Antonio , Ivanova Svetlana 
Published: November 2019

AbstractA series of gold nanoparticles in the 4–40 nm range were prepared, immobilized on activated carbon and further tested, at low base concentration, in the catalytic oxidation of 5‐hydroxymethyl furfural (HMF) to 2,5‐furandicarboxylic acid (FDCA). Gold particles size variation has no influence on HMF conversion but significantly affects product selectivity and carbon balance. This behavior is ascribed to the thermodynamically favorable oxygen reduction reaction on Au(100) faces. As the gold particle size decreases the Au(100)/Au(111) exposure ratio, estimated by using the van Hardeveld‐Hartog model, increases as well as the FDCA selectivity. The smaller the gold particle size the smaller the 5‐hydroxymethyl‐2‐furancarboxylic acid (HMFCA) to FDCA ratio pointing to the gold size dependent behavior of the oxidation of the alcohol function of the HMF molecule.
Transient in‐situ DRIFTS Investigation of Catalytic Oxidation of Toluene over α‐, γ‐ and β‐MnO2
Authors: Fan Jie , Ren Quanming , Mo Shengpeng , Sun Yuhang , Fu Mingli , Wu Junliang , Chen Limin , Chen Peirong , Ye Daiqi 
Published: November 2019

AbstractManganese oxides with different crystal phases (i. e. α‐MnO2, γ‐MnO2 and β‐MnO2) were synthesized for catalytic oxidation of toluene. The catalytic activity was strongly influenced by the crystal phases of MnO2. α‐MnO2 exhibited the highest catalytic activity with a 50 % toluene conversion (T50) at 229 °C and a 90 % toluene conversion (T90) at 238 °C, followed by γ‐MnO2 (T90=252 °C) and β‐MnO2 (T90=278 °C). The remarkable catalytic activity of α‐MnO2 was attributed to its superior redox property and lattice oxygen mobility. Different intermediates were detected on the surfaces of α‐, γ‐ and β‐MnO2 by in situ diffuse reflectance infrared Fourier transform spectroscopy (in‐situ DRIFTS). Benzoate species were found to be the key intermediates on α‐MnO2 at 240 °C, while benzoyl oxide species and benzoate were the major intermediates on γ‐MnO2 at 260 °C. The surface of β‐MnO2 was mainly covered by carbonate and benzoate species after the adsorption of toluene at 280 °C.
Spectroscopic study of porphyrin self‐assembly: Role of pH, time, and chiral template
Authors: Thorpe Stephanie L. , Snyder Gabrielle N. , Mammana Angela 
Published: November 2019

AbstractIn this study, we performed an ultraviolet‐visible (UV‐Vis) and circular dichroism (CD) spectroscopic analysis of the binary and ternary supramolecular structures formed by self‐assembling the following three water‐soluble porphyrins with and without a chiral template: the negatively charged, meso‐Tetra(4‐sulfonatophenyl) porphine (H2TPPS4−); the positively charged meso‐trans‐(di(N‐methyl‐4‐pyridyl)diphenyl) porphine (trans‐DmPyDPP) and meso‐cis‐(di(N‐methyl‐4‐pyridyl)diphenyl) porphine (cis‐DmPyDPP). Polyglutamic acid (both L and D enantiomers) was selected as the chiral template due to its ability to change secondary structure with pH. The propensity for the porphyrins to show an induced CD in the presence of polyglutamic acid is demonstrated. The induced chirality of all supramolecular structures was found to depend on the pH of the solution, the chirality of the polymer, and the order of addition of the positively and negatively charged porphyrins (for ternary complexes). Of particular interest is that the interaction of H2TPPS4− with the chiral scaffold seems to undergo a dynamic rearrangement of the supramolecular structure as evident from the change in the CD spectrum over time. Moreover, experiments with ternary complexes suggest that the preferential interaction of trans‐DmPyDPP with the random coil of the polymer shows promise as a sensor of protein secondary structure.
A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells
Authors: Yong Cassandra , Devine Shane M. , Gao Xuexin , Yan Angelina , Callaghan Richard , Capuano Ben , Scammells Peter J. 
Published: November 2019

AbstractNoscapine displays weak anticancer efficacy and numerous research efforts have attempted to generate more potent noscapine analogues. These modifications included the replacement of the N‐methyl group in the 6′‐position with a range of substituents, where N‐ethylcarbamoyl substitution was observed to possess enhanced anticancer activity. Herein, we describe advances in this area, namely the synthesis and pharmacological evaluation of a series of N‐sulfonyl and N‐sulfamoyl noscapine derivatives. A number of these sulfonyl‐containing noscapinoids demonstrated improved activities compared to noscapine. ((R)‐5‐((S)‐4,5‐Dimethoxy‐1,3‐dihydroisobenzofuran‐1‐yl)‐4‐methoxy‐6‐((1‐methyl‐1H‐imidazol‐4‐yl)sulfonyl)‐5,6,7,8‐tetrahydro[1,3]dioxolo[4,5‐g]isoquinoline) (14 q) displayed sub‐micromolar activities of 560, 980, 271 and 443 nM against MCF‐7, PANC‐1, MDA‐MB‐435 and SK‐MEL‐5 cells, respectively. This antiproliferative effect was also maintained against drug‐resistant NCI/AdrRES cells despite high expression of the multidrug efflux pump, P‐glycoprotein.
The economic research of arsenic trioxide for the treatment of newly diagnosed acute promyelocytic leukemia in China
Authors: Chen Xichuang , Hong Yuan , Zheng Panpan , You Xiaohong , Feng Jinhua , Huang Zhihu , Wang Yan 
Published: November 2019

BackgroundThe objective of this study was to conduct the first systematic evaluation of the long‐term economic impact of arsenic trioxide (ATO) plus all‐trans retinoic acid (ATRA) for the treatment of patients with newly diagnosed acute promyelocytic leukemia (APL) from the perspective of the Chinese health care system.MethodsOn the basis of clinical data from a randomized phase 3 trial, a time‐dependent Markov model with 4 health states (complete remission, relapse or treatment failure, post‐treatment failure, and death) was used to evaluate the incremental costs per quality‐adjusted life‐year (QALY) gained from the ATO plus ATRA regimen compared with the ATRA plus chemotherapy (CT) regimen over a 30‐year period. All costs were adjusted to 2018 levels based on the Chinese Consumer Price Index. Both costs and health outcomes were discounted by 3% annually. One‐way sensitivity analysis and probability sensitivity analysis were performed.ResultsCompared with the ATRA plus CT strategy, the ATO plus ATRA strategy was associated with 1.38 additional QALYs gained and $392.05 (estimated in 2018 US dollars) in incremental costs per patient over 30 years. Consequently, the incremental cost‐effectiveness ratio was $284.02 per QALY gained, which was far below the Chinese willingness‐to‐pay threshold of $29,306 per QALY gained. Sensitivity analyses demonstrated the robustness of these results.ConclusionsFrom the perspective of the Chinese health care system, the ATO plus ATRA strategy is cost‐effective for patients with newly diagnosed APL compared with the ATRA plus CT strategy. Therefore, the authors strongly suggest that China's health authorities choose the former strategy for these patients, whether for the elderly or for young people.
Postdiagnosis sedentary behavior and health outcomes in cancer survivors: A systematic review and meta‐analysis
Authors: Swain Christopher T. V. , Nguyen Nga H. , Eagles Tobyn , Vallance Jeff K. , Boyle Terry , Lahart Ian M. , Lynch Brigid M. 
Published: November 2019

BackgroundHigh levels of sedentary behavior may negatively affect health outcomes in cancer survivors. A systematic review and meta‐analysis was performed to clarify whether postdiagnosis sedentary behavior is related to survival, patient‐reported outcomes, and anthropometric outcomes in cancer survivors.MethodsThe Ovid MEDLINE, EMBASE, CINAHL (The Cumulative Index to Nursing and Allied Health Literature), and SPORTDiscus databases were searched from study inception to June 2019. Studies of adults who had been diagnosed with cancer that examined the association between sedentary behavior and mortality, patient‐reported outcomes (eg, fatigue, depression), or anthropometric outcomes (eg, body mass index, waist circumference) were eligible for inclusion. Meta‐analyses were performed to estimate hazard ratios for the highest compared with the lowest levels of sedentary behavior for all‐cause and colorectal cancer‐specific mortality outcomes. The ROBINS‐E (Risk of Bias in Nonrandomized Studies‐of Exposures tool) and the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) system were used to assess the risk of bias and the strength of evidence, respectively.ResultsThirty‐three eligible publications from a total of 3569 identified articles were included in the review. A higher level of postdiagnosis sedentary behavior was associated with an increased risk of all‐cause mortality (hazard ratio, 1.22; 95% CI, 1.06‐1.41; heterogeneity [I2 statistic], 33.8%) as well as colorectal cancer‐specific mortality (hazard ratio, 1.53; 95% CI, 1.14‐2.06; I2, 0%). No clear or consistent associations between sedentary behavior and patient‐reported or anthropometric outcomes were identified. The risk of bias in individual studies ranged from moderate to serious, and the strength of evidence ranged from very low to low.ConclusionsAlthough avoiding high levels of sedentary behavior after a cancer diagnosis may improve survival, further research is required to help clarify whether the association is causal.
Human epididymis protein 4 antigen‐autoantibody complexes complement cancer antigen 125 for detecting early‐stage ovarian cancer
Authors: Yang Wei‐Lei , Lu Zhen , Guo Jing , Fellman Bryan M. , Ning Jing , Lu Karen H. , Menon Usha , Kobayashi Makoto , Hanash Samir M. , Celestino Joseph , Skates Steven J. , Bast Robert C. 
Published: November 2019

BackgroundEarly detection of ovarian cancer could significantly improve patient outcomes. Cancer antigen 125 (CA 125) is elevated in sera from approximately 60% of patients with early‐stage (I/II) disease. Sensitivity might be improved through the combination of CA 125 with other biomarkers. Among potential biomarkers, antigen‐autoantibody (Ag‐AAb) complexes have received relatively little attention.MethodsLuminex‐based immunoassays were used to measure human epididymis protein 4 (HE4), anti‐HE4 autoantibody, and HE4 Ag‐AAb complexes in sera from patients with early‐ (n = 73) and late‐stage ovarian cancers (n = 49) at the time of diagnosis and from asymptomatic women with (n = 15) or without ovarian cancer (n = 212) enrolled in the Normal Risk Ovarian Cancer Screening Study.ResultsAt 98% specificity for healthy, asymptomatic women, 7% of patients with early‐stage (I/II) ovarian cancer and 4% of patients with late‐stage (III/IV) disease had elevated levels of HE4 autoantibody, whereas elevated levels of HE4 Ag‐AAb complexes were detected in sera from 38% of early‐stage cases and 31% of late‐stage cases. Complementarity was observed in receiver operating characteristic (ROC) curves between HE4 Ag‐AAb complexes and CA 125 levels in early‐stage ovarian cancer (P < .001). CA 125 detected 63% of cases, and a combination of CA 125 and HE4 Ag‐AAb complexes detected 81%. Complementarity was also observed in ROC curves for an independent validation set with 69 early‐stage patients (P = .039). HE4 Ag‐AAb complexes were detected in serial preclinical serum samples from women destined to develop ovarian cancer: they correlated with CA 125 but did not provide a lead time.ConclusionsHE4 Ag‐AAb complexes could complement CA 125 in detecting a higher fraction of early‐stage ovarian cancers.
Cloud‐based difference algorithm using big GPR data for roadbed damage detection
Authors: Xu Xianlei , Gao Wenru , Zhang Di , Li Taotao , Qiao Xu 
Published: November 2019

SummaryGround‐penetrating radar (GPR) technology is being widely used for urban roadbed damage detection. In this paper, we present the development of a cloud‐based difference detection method using big GPR data for roadbed damage detection. Unlike many processing methods relying on standalone servers, the proposed method can achieve high accuracy and processing efficiency by distributing the computation over a server cluster. The method includes a difference detection algorithm for GPR image enhancement and damage extraction, the Hadoop Distributed File System, and MapReduce distributed parallel computing framework for big GPR data parallel processing and interpretation. Moreover, to automatize roadbed damage classification, a criterion with seven grades is established based on the wave group shape, amplitude, phase, and attenuation characteristics. We validate the proposed method through a detection experiment that was conducted on the Fourth Ring Road in Beijing, China. The detection revealed 187 damage from the efficient processing of big GPR data, thus suggesting the ability of the proposed method to provide timely support for road safety in cities.
RbSbO3: A Simple Structure with Complex Polytypism
Authors: Rotter Markus , Stöger Berthold 
Published: November 2019

AbstractRbSbO3 crystallizes in different polytypes composed of trigonal [SbO3]− and [Rb]+ layers, which can appear in two orientations with respect to m<100> and m<120>, respectively. The order–disorder (OD) polytype family comprises four polytypes of a maximum degree of order (MDO), of which two are realized in actual crystals: MDO1 (, c ≈ 19.8 Å, isotypic to ilmenite‐like KSbO3) and MDO2 (, c ≈ 39.2 Å, isotypic to AgRuO3). Crystals grown from RbF:Sb2O5 in a 2:1 ratio are MDO1:MDO2 allotwins, whereas crystals grown from a 12:1 mixture are composed of MDO2 only. The stacking ambiguity leads to twinning by rotation about <100> or <120>. KSbO3 crystals grown from KF:Sb2O5 are composed of the MDO1 polytype only. The crystals are fourfold twins owing to stacking faults. A detailed description of the analysis of the diffraction data is given.
In Situ Precipitation‐Induced Growth of Leaf‐like CuO Nanostructures on Cu–Ni Alloys for Binder‐Free Anodes in Li‐Ion Batteries
Authors: Ha Jaeyun , Kim Yong‐Tae , Choi Jinsub 
Published: November 2019

AbstractCuC2O4⋅x H2O was facilely prepared on a Cu–Ni alloy substrate by in situ precipitation‐induced growth by using a mixture of sodium persulfate, hydrogen peroxide, and oxalic acid. Thermal annealing allowed the conversion of CuC2O4⋅x H2O to leaf‐like CuO nanostructures with a thickness of a few tens of micrometers of sub‐sized nanoparticles, which were applied for fabricating binder‐free anodes for lithium‐ion batteries. Ni was a nucleation site for CuC2O4⋅x H2O, which was uniformly formed on the entire substrate. The concentration of each component in the mixture solution caused significant morphological changes because of the different elution of copper ions. CuO nanostructures annealed at 550 °C showed large areal and gravimetric capacity with excellent capacity retention of 95.5 % after 200 cycles at a high current density because of their appropriate structural morphology, which not only allowed the formation of a stable solid electrolyte interphase layer but also enabled a reversible reaction during the charge/discharge process.
Visible‐Light‐Induced Metal‐Free Synthesis of 2‐Phosphorylated Thioflavones in Water
Authors: Liu Xiao‐Ceng , Chen Xiao‐Lan , Liu Yan , Sun Kai , Peng Yu‐Yu , Qu Ling‐Bo , Yu Bing 
Published: November 2019

AbstractThe introduction of phosphorus functional groups into the skeleton of thioflavones is an attractive task and of great significance. Herein, a metal‐free visible‐light‐induced radical cascade cyclization was developed for the preparation of 2‐phosphorylated thioflavones from methylthiolated alkynones and phosphine oxides. In water as a green reaction medium, a large number of such 2‐phosphorylated thioflavones were prepared, catalyzed by 4CzIPN [1,2,3,5‐tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobenzene] under visible‐light irradiation. These reactions could be performed at ambient temperature and feature simple operation, wide reaction scope, and recyclability of aqueous media.
Capsule‐Structured Copper–Zinc Catalyst for Highly Efficient Hydrogenation of Carbon Dioxide to Methanol
Authors: Guo Yongle , Guo Xinwen , Song Chunshan , Han Xinghua , Liu Hongyang , Zhao Zhongkui 
Published: November 2019

AbstractInvited for this month′s cover is the Advanced Catalytic Materials Research Group of Prof. Zhongkui Zhao at Dalian University of Technology. The image shows an innovative capsule strategy with a core–shell structure containing different Cu‐based catalyst components for more efficient conversion of CO2 to methanol. The Full Paper itself is available at 10.1002/cssc.201902485.
Aerobic Oxidation of 5‐Hydroxymethylfurfural to 2,5‐Furandicarboxylic Acid over Holey 2 D Mn2O3 Nanoflakes from a Mn‐based MOF
Authors: Bao Liwei , Sun Fang‐Zhou , Zhang Guo‐Ying , Hu Tong‐Liang 
Published: November 2019

AbstractThe aerobic oxidation of 5‐hydroxymethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA), a promising renewable monomer to produce bio‐based polymers such as polyethylene furanoate (PEF), has recently emerged as the subject of increasing interest. Here, holey 2 D Mn2O3 nanoflakes were obtained by a facile thermal treatment of a Mn‐based metal–organic framework (MOF) precursor. The structural and morphological properties of the nanoflakes were characterized by powder XRD, FTIR, SEM and TEM to explore the formation process. It was inferred that the linker loss in the MOF precursor and the oxidation of the Mn cation induced by the heat‐treatment in air were responsible for the formation of holey 2 D Mn2O3 nanoflakes. The specific morphology and redox cycle of the Mn cation on the surface endowed the synthesized nanoflakes with promising performance on the selective oxidation. The obtained nanoflakes calcined at 400 °C (M400) afforded over 99.5 % yield of FDCA at complete conversion of HMF, which is superior to the catalytic activity of commercial Mn2O3 and activated MnO2. To our knowledge, Mn2O3 exhibiting such a high performance on the aerobic oxidation of HMF to FDCA has not yet been reported. Based on the investigation of the experimental parameters, a plausible reaction mechanism was proposed.
Cytologic features of vaping‐induced lung injury: A case report
Authors: Ocampo‐Gonzalez Fernando Alekos , Park Ji‐Weon 
Published: November 2019

AbstractVaping‐induced lung injury is a recently recognized phenomenon owing to the rising popularity of e‐cigarette use. A cluster of cases of varying severity, including six deaths, was recently reported in the United States by the Centers for Disease Control. The objective of this report is to highlight the cytologic features suggestive of vaping‐induced lung injury. A 20‐year‐old previously healthy man presented with a 7‐day history of progressively worsening respiratory symptoms including dyspnea on exertion, cough, and fever, with no improvement after initiating a course of antibiotics. No relevant travel or occupational history was reported, but patient endorsed daily use of e‐cigarette with a fluid containing both tetrahydrocannabinol and nicotine. Radiographic studies demonstrated scattered areas of interlobular septal thickening and diffuse ground‐glass opacities in both lungs. Laboratory tests for HIV and influenza were negative. Bronchoscopy and bronchoalveolar lavage were performed, with cytologic study showing clusters of benign bronchial cells and an increase in lipid‐laden macrophages by Oil Red O stain. Patient was placed on steroid and steadily improved for the next 2 days. He was discharged on a steroid taper and follow‐up with respiratory clinic. Case reports and series have shown a variety of lung injury patterns in previously healthy patients who are frequent users of e‐cigarettes and among them features suggestive of lipoid pneumonia with increased lipid‐laden macrophages. The clinical utility of this finding is still unclear.