bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desa Wisata Berbasis Wisata Ramah Anak di Desa Wisata Pemuteran Kabupaten Buleleng Provinsi Bali (Suatu Studi Kualitatif)
Authors: Sugiarti Dian Pramita , Sastrawan I Gede Anom , Ariwangsa I Made Bayu , Putri Nyoman Manik Mas Genitri 
Published: December 2020

Tourists who come to visit Bali with their families will visit child-friendly tourist villages. The goal is that the child has a sense of security and comfort when visiting a tourist village. The experience will learn a new tourist area will increase enthusiasm and refresh children from all their activities. The identification of child- friendly tourism-based tourism villages is carried out to determine the level of safety, comfort and learning that children will get when carrying out tourism activities in the tourist village of Pemuteran, Buleleng Regency. The problem raised in this study is the identification of child-friendly tourism-based tourism villages and the identification of supporting facilities provided by tourism service providers in Pemuteran tourism village, Buleleng Regency.
Keywords : Tourist Destination, Child Friendly, Tourist Villages.
Timing of deformation along the Iron Springs thrust, southern Sevier fold-and-thrust belt, Utah: Evidence for an extensive thrusting event in the mid-Cretaceous
Authors: Quick J. Daniel , Hogan John P. , Wizevich Michael , Obrist-Farner Jonathan , Crowley James L. 
Published: December 2020

ABSTRACT
The temporal and spatial distribution of strain associated with the Sevier orogeny in western North America is significantly different in the southern end of the belt, at the latitude of Las Vegas, Nevada, than farther to the north at the latitude of Salt Lake City, Utah. Reasons for these differences have been speculative as a lack of temporal constraints on thrusting in the intervening region hindered along-strike correlation across the belt. We determined a crystallization age of 100.18 ± 0.04 Ma for zircons extracted from a recently recognized dacite lapilli ash-fall tuff near the base of the synorogenic Iron Springs Formation. We propose the name “Three Peaks Tuff Member” for this unit, and identify a type stratigraphic section on the western flank of the “Three Peaks,” a topographic landmark in Iron County, Utah. Field relationships and this age constrain movement on the Iron Springs thrust and the end of the sub-Cretaceous unconformity in the critical intervening area to latest Albian/earliest Cenomanian. Movement on the Iron Springs thrust was synchronous with movement on multiple Sevier thrusts at ~100 Ma, indicating that the mid-Cretaceous was a period of extensive thrust-fault movement. This mid-Cretaceous thrusting event coincided with a period of global plate reorganization and increased convergence, and hence an increased subduction rate for the Farallon Plate beneath North America. The accelerated subduction contributed to a Cordilleran arc flare-up event and steepening of the orogenic wedge, which triggered widespread thrusting across the retroarc Sevier deformation belts. Additionally, based on temporal constraints and the strong spatial connection of mid-Cretaceous thrusts to lineaments interpreted as pre-orogenic transform faults, we suggest that temporal and spatial variations along the strike of the orogenic belt reflect tectonic inheritance of basement structures associated with the edge of the rifted Precambrian craton.
TİROİD İNCE İĞNE ASPİRASYON BİYOPSİSİ SONUCU ÖNEMİ BELİRSİZ ATİPİ TANISI KONULAN HASTALARIN DEĞERLENDİRİLMESİ
Authors: SAHİN Serdar , ÇAVUŞOĞLU Turgut , KUBAT Mehmet , ÜSTÜN Hüseyin 
Published: December 2020

Amaç: Tiroid bez
hastalıkları en önemli endokrin sorunlarından biridir. Tiroid
ince iğne aspirasyon biyopsisi (TİİAB)'nin ana
rolü; hastaları cerrahi ve konservatif tedavi seçenekleri açısından ayırt
etmektir. Bu çalışma ile Ankara Eğitim ve Araştırma Hastanesi’nde
tiroidektomi operasyonu uygulanmış hastalara ilişkin tiroid ince iğne
aspirasyon biyopsisi (TİİAB) sonuçları ile histopatoloji rapor sonuçlarının
karşılaştırılarak, tiroid nodüllerindeki İİAB etkinliğinin değerlendirilmesi
amaçlanmıştır.Gereç ve Yöntemler: Ankara
Eğitim ve Araştırma Hastanesi’nde 2007-2012 yılları arasında TİİAB sonucu önemi
belirsiz atipi (AUS) tanısı konulan ve troidektomi operasyonu yapılan hastaların
histopatolojik verileri karşılaştırıldı.Bulgular: Çalışmamıza
toplam 87 hasta dahil edildi. 77 (% 88.5) hasta kadın, 10 (% 11.5) hasta
erkekti. 77 kadın hastaya 55'i (% 71.4) benign, 22'si (% 28.6) malign nodül
teşhisi konuldu. On erkek hastanın 8'ine (% 80) benign, 2'sine (% 20) malign
nodül teşhisi konmuştur.

Sonuç: Önemi belirsiz atipi
teşhisi konan hastalar, yaş ve cinsiyet gibi demografik özellikleri, radyolojik
inceleme, ayrıntılı öykü ve fizik muayene dahil olmak üzere klinik olarak bir
bütün olarak değerlendirilmeli ve cerrahi kararları bu özelliklere göre
verilmelidir.
Interventionist performs a “sham” lumbar microdiscectomy: Should interventionalists be performing spinal surgery?
Authors: Ghaly Ramsis F. , Perciuleac Zinaida , Candido Kenneth D. , Knezevic Nebojsa Nick 
Published: December 2020

Background:
Neurosurgeons and orthopedists, who have received specific training, should be the ones performing spinal surgery. Here, we present a case in which spinal surgeons secondarily (e.g., 6 months later) found that a patient’s first lumbar discectomy, performed by an interventional specialist, had been a “sham” procedure.

Case Description:
A 30-year-old male presented with sciatica attributed to a magnetic resonance imaging documented large, extruded disc at the L4-5 level. An interventional pain management specialist (IPMS) performed two epidural steroid injections; these resulted in an exacerbation of his pain. The IPMS then advised the patient that he was a surgeon and performed an “interventional” microdiscectomy. Secondarily, 6 months later, when the patient presented to a spinal neurosurgeon with a progressive cauda equina syndrome, the patient underwent a bilateral laminoforaminotomy and L4-L5 microdiscectomy. Of interest, at surgery, there was no evidence of scarring from the IPMS’ prior “microdiscectomy;” it had been a “sham” operation. Following the second surgery, the patient’s cauda equina syndrome resolved.

Conclusion:
IMPS, who are not trained as spinal surgeons should not be performing spinal surgery/ microdiscectomy.
Nonconvulsive status epilepticus associated with Alzheimer’s disease mimicking symptomatic focal epilepsy following the resection of a frontal parasagittal meningioma
Authors: Abe Keisuke , Mukae Nobutaka , Morioka Takato , Sangatsuda Yuhei , Sakata Ayumi , Suzuki Satoshi O. , Mizoguchi Masahiro 
Published: December 2020

Background:
Epilepsies are frequent in patients with Alzheimer’s disease (AD); however, epilepsies in AD can easily go unrecognized because they usually present as focal impaired awareness seizures or nonconvulsive status epilepticus (NCSE) and can overlap with other symptoms of AD.

Case Description:
We performed an epilepsy surgery in a 69-year-old woman with progressive cognitive impairment and consciousness disorder, who was diagnosed with focal NCSE related to the resected meningioma in the right frontal parasagittal region. Intraoperative electrocorticography revealed localized periodic paroxysmal discharges with beta and gamma activities in the neighboring cortex where the meningioma existed. The histopathological diagnosis of AD was first made from the resected epileptogenic cortex.

Conclusion:
Even when there is a suspected epileptogenic lesion that could cause focal NCSE, AD should be ruled out in elderly patients with progressive cognitive decline.
Management dilemma of tuberculous paraplegia in pregnancy – A case report and review of literature
Authors: Srivastava Sudhir , Raj Aditya , Agarwal Rishi , Bhosale Sunil , Marathe Nandan 
Published: December 2020

Background:
Tuberculosis (TB)/tuberculous spondylodiscitis of the spine causing paraplegia in the 2nd trimester of pregnancy is rare and poses significant management dilemmas. Pregnancy, a relatively immunocompromised state with high hormonal levels, may prompt rapid TB destruction of a vertebral body resulting in an acute/ profound neurological deficit. Here, a pregnant paraplegic mother was diagnosed with spondylodiscitis that warranted immediate decompression/fusion to achieve neurological recovery.

Case Description:
A 26-year-old female was 23 weeks pregnant when she presented with an acute spastic paraplegia (complete motor, sensory deficit, and sphincter loss). Operative decompression utilized a Versatile Approach along with a “Hartshill rectangle” for fusion and sublaminar wiring. This procedure accomplished simultaneous anterior and posterior fixation with a single approach without the need for intraoperative radiologic imaging. Although the pregnancy was continued with an uneventful perioperative period, intra-uterine fetal demise was documented 1 month postoperatively. Within 18 postoperative months the patient was neurologically intact, and fusion was confirmed on a computed tomography scan.

Conclusion:
A 23-week pregnant female acutely became paraplegic due to T5 tuberculous spondylitis confirmed on an X-ray (only source of radiation), and magnetic resonance imaging. Following a decompression/ instrumented fusion performed without fluoroscopic guidance, the patient regained full neurological function. However, 1 month postoperatively, the fetus spontaneously aborted.
Successful balloon-assisted coil embolization for a diagnostically difficult case of spontaneous vertebrovertebral arteriovenous fistula
Authors: Mizuhashi Satomi , Kominami Shushi , Fukuda Kazumasa 
Published: December 2020

Background:
We describe a rare case of idiopathic lower cervical vertebro-vertebral arteriovenous fistula (VVAVF) with compression of the nerve roots and spinal cord, successfully treated with detachable coils utilizing the transarterial balloon-assisted technique without complication of coil mass.

Case Description:
A 68-year-old woman was admitted for numbness of the left upper limb and pain in the left neck. Cervical magnetic resonance imaging (MRI) revealed compression of nerve roots and spinal cord by a large vascular lesion. The left vertebral angiography demonstrated a VVAVF draining into the vertebral venous plexus at C5 level. Under general anesthesia, the fistula site was accessed with a microcatheter through the right femoral artery, and successful embolization performed by compactly placing several detachable coils using balloon-assisted technique. The patient made a full recovery, with long-term MRI-documented left vertebral artery patency and no fistular leakage, and without postoperative complications.

Conclusion:
Target occlusion utilizing the balloon-assisted technique in this case of VVAVF with compression of nerve roots and spinal cord, was effective in improving neurological symptoms, and achieved long-term occlusion when preservation of the VA was desired.
Preliminary development of a deep learning-based automated primary headache diagnosis model using Japanese natural language processing of medical questionnaire
Authors: Katsuki Masahito , Narita Norio , Matsumori Yasuhiko , Ishida Naoya , Watanabe Ohmi , Cai Siqi , Tominaga Teiji 
Published: December 2020

Background:
Primary headaches are widespread and costly public health problems. However, there are insufficient medical resources for their treatment in Japan due to two reasons. First, the numbers of headache specialists and clinics remain insufficient. Second, neurologists and neurosurgeons mainly treat headaches in Japan. However, they mainly work as general stroke neurologists, so they cannot focus on primary headache treatment. To solve these problems, we preliminarily developed a deep learning (DL)-based automated diagnosis model from patients’ Japanese unstructured sentences in the medical questionnaire using a DL framework. We hypothesized that the model would reduce the time and burden on both doctors and patients and improve their quality of life.

Methods:
We retrospectively investigated our primary headache database and developed a diagnosis model using the DL framework (Prediction One, Sony Network Communications Inc., Japan). We used age, sex, date, and embedding layer made by the medical questionnaire’s natural language processing (NLP).

Results:
Eight hundred and forty-eight primary headache patients (495 women and 353 men) are included. The median (interquartile range) age was 59 (40–74). Migraine accounted for 46%, tension-type headache for 47%, trigeminal autonomic cephalalgias for 5%, and other primary headache disorders for 2%. The accuracy, mean precision, mean recall, and mean F value of the developed diagnosis model were 0.7759, 0.8537, 0.6086, and 0.6353, which were satisfactory.

Conclusion:
The DL-based diagnosis model for primary headaches using the raw medical questionnaire’s Japanese NLP would be useful in performing efficient medical practice after ruling out the secondary headaches.
A new approach to treatment of stomatitis in experiments on white rats (experimental research)
Authors: Ганина Е.Б. , Червинец Ю.В. , Грудинин Н.В. , Шестакова В.Г. , Червинец В.М. , Миронов А.Ю. 
Published: December 2020

Цель исследования - охарактеризовать микробиологическую картину стоматита до и после его лечения высокоактивными культурами лактобацилл, дать оценку эффективности их применения при экспериментальном стоматите. Методика. Опыты проводились на 32 самках беспородных белых крыс массой 230 г. Моделирование стоматита включало 2 этапа: моделирование травматического стоматита и воспроизведение бактериального стоматита на базе травматического. У крыс контрольной и опытных серий на всех этапах эксперимента брали мазки с поверхности десен для характеристики микробиоценоза ротовой полости. Результаты. После обработки слизистой оболочки полости рта (СОПР) культурой патогенного штамма Staphylococcus aureus существенно снизились частота встречаемости и количество условно-патогенных микроорганизмов. Лечение стоматита у крыс культурами лактобацилл ( Lactobacillus 11 зв., Lactobacillus 2 п.рта, Lactobacillus 24 д.ст.) и их комбинацией приводило к снижению распространенности S. aureus вплоть до его исчезновения, а также к нормализации количества условно-патогенной микробиоты. Заключение. Исследования показали эффективность использования отдельных высокоактивных штаммов лактобацилл или их комбинации при лечении заболеваний СОПР, в частности бактериального стоматита.
Aim. To characterize the microbiological picture of stomatitis in intact rats before and after the treatment with highly active cultured lactobacilli and to evaluate the effectiveness of this treatment in experiments on white rats. Methods. Experiments were carried out on 32 mongrel female white rats weighing 230 g. Smears were taken from the gum surface of control and experimental rats at all stages of the experiment to characterize the oral cavity microbiocenosis. Results. After treatment of the oral cavity with cultured Staphylococcus aureus , the occurrence and quantity of opportunistic microorganisms significantly decreased. The treatment of stomatitis in rats with cultured lactobacillus ( Lactobacillus 11 zv., Lactobacillus 2 p.r., Lactobacillus 24 d.st. and their combination) led to a decrease in S. aureus prevalence up to its extinction and to normalization of the quantitative composition of opportunistic microbiota. Conclusions. The study showed the effieacy of highly active lactobacillus strains individually or their combinations in the treatment of oral diseases, in particular, bacterial stomatitis.
Hyperhomocysteinemia and chronic kidney disease
Authors: Круглова М.П. , Иванов А.В. , Введенская О.Ю. , Кубатиев А.А. 
Published: December 2020

Гипергомоцистеинемия (ННсу) является независимым фактором риска развития сердечно-сосудистых осложнений, а также непосредственной причиной ренальных повреждений у пациентов с хронической болезнью почек (ХБП). В данном обзоре рассмотрены возможные механизмы нарушения метаболизма гомоцистеина (Нсу) при ХБП, а также молекулярные и клеточные механизмы повреждений, опосредованных гипергомоцистеинемией (ННсу)Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease and the direct cause of renal injury in patients with chronic kidney disease (CKD). This review considers the potential mechanisms of homocysteine (Hcy) metabolism disorders, and pathogenesis of molecular and cellular damage mediated by hyperhomocysteinemia (ННсу)
Neurobiological predisposition to addictive disorders. Antibodies to neurotransmitters
Authors: Давыдова Т.В. , Невидимова Т.И. , Ветрилэ Л.А. , Захарова И.А. , Савочкина Д.Н. , Бохан Н.А. 
Published: December 2020

Выявление нейробиологической предрасположенности к развитию аддиктивных расстройств является актуальной задачей при решении проблемы профилактики болезней зависимости от психоактивных веществ. Ключевую роль в разработке этой проблемы играет изучение молекулярных нейроиммунных механизмов регуляции нейромедиации в развитии аддиктивных расстройств. Целью работы было изучение в сыворотке крови иммуноферментным методом содержания аутоантител к нейромедиаторам для построения паттерна их изменения при формировании зависимости к психоактивным веществам. Показано, что система антител к дофамину, норадреналину, глутамату изменяется в процессе развития зависимости от психоактивных веществ и может рассматриваться в качестве нейроиммунного маркера для выявления групп риска развития наркомании.
Identification of neurobiological susceptibility to addictive disorders is an important issue of preventing psychoactive substance dependence. A key role in approaching this issue belongs to studying molecular neuroimmune mechanisms for neurotransmission regulation during development of addictive disorders. The aim of this study was to construct a pattern of changes in serum neurotransmitter autoantibodies during formation of psychoactive substance dependence using immunoassay. The system of antibodies to dopamine, norepinephrine, and glutamate changed during the development of psychoactive substance dependence and can be considered as a neuroimmune marker for identifying groups at risk of drug addiction.
Preventive phototherapy in the blue range of optical radiation in preparation for underwater activities
Authors: Карганов М.Ю. , Панкова Н.Б. , Карандашов В.И. , Черепов А.Б. 
Published: December 2020

Исследовали эффекты профилактического оптического излучения в синем диапазоне в течение четырех недель на функциональное состояние кардио-респираторной системы человека. При тестировании использовали нагрузочные пробы. Эффекты фототерапии проявились в отсутствии изменений ряда показателей сердечно-сосудистой системы, характерных для периода максимального прироста светового дня.
Effects of preventive optical radiation in the blue range on the functional state of the human cardiorespiratory system were studied for four weeks using loading tests. The effects of phototherapy were evident as the absence of changes in several cardiovascular indexes characteristic for the period of maximum increase in daylight hours.
Plasma low molecular weight aminothiols in patients with acute ischemic stroke
Authors: Максимова М.Ю. , Булгакова П.О. , Иванов А.В. , Вирюс Э.Д. , Александрин В.В. , Никифорова К.А. , Охтова Ф.Р. , Суанова Е.Т. , Пирадов М.А. , Кубатиев А.А. 
Published: December 2020

Цель: оценить гомеостаз низкомолекулярных аминотиолов (цистеина, цистеинил-глицина, гомоцистеина и глутатиона) в плазме крови в остром периоде ишемического инсульта. Методика. Обследован 41 пациент с атеротромботическим и кардиогенным эмболическим инсультом. 31 пациент с хронической ишемией головного мозга был включен в контрольную группу. Общий уровень низкомолекулярных аминотиолов и уровни их восстановленных форм определяли в 1-е, 3-и, 7-е и 15-е сут. инсульта. Результаты. Уровни восстановленных форм цистеина и цистеинил-глицина у больных с инсультом были снижены в 1-е-7-е сут. инсульта. Наблюдалось раннее повышение общего содержания глутатиона и цистеина, носящее, по всей видимости, адаптивный характер. Различий между уровнями низкомолекулярных аминотиолов у пациентов с атеротромботическим и кардиогенным подтипами инсульта выявлено не было. Анализ логистической регрессии показал, что исходные уровни восстановленного гомоцистеина, общего цистеинил-глицина и редокс-статус цистеина у пациентов являлись прогностическими факторами возникновения атеротромботического и кардиогенного эмболического инсульта с вероятностью 86,2% (р <0,001). Выводы. Уровни низкомолекулярных аминотиолов ассоциируются с тяжестью неврологических нарушений и объемом инфарктов головного мозга. Их определение может иметь диагностическое значение как в острейшем периоде ишемического инсульта, так и при мониторинге его течения.
Objectives: To evaluate homeostatic disorders of plasma low molecular weight aminothiols (LMWTs: cysteine, cysteinylglycine, homocysteine, and glutathione) during acute and early subacute stages of ischemic stroke. Patients and Methods: 41 patients with primary large-artery atherosclerosis and cardioembolic stroke were admitted within the first 6-24 h of the onset of neurologic symptoms. The control group included 31 patients with chronic cerebral ischemia. Concentrations of total LMWTs and their reduced forms were measured on days 1, 3, 7, and 15 after stroke. Results and Discussion: Concentrations of cysteine and cysteinylglycine reduced forms were decreased in patients with stroke on days 1-7. Also, early adaptive increases in total glutathione and cysteine levels were observed. LMWT concentrations did not differ between stroke subtypes. The analysis of logistic regression indicated that concentrations of reduced homocysteine and total cysteinylglycine and the redox status of cysteine at admission were predictive factors for development of ischemic stroke with a probability of 86.2% (p < 0.001). Conclusion: Concentrations of LMWTs may indicate the severity of neurological deficit and the size of cerebral infarct. Measuring these concentrations can be diagnostically important both at an early stage of ischemic stroke and during stroke monitoring.