bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
Authors: Cole Kristina A. , Pal Sharmistha , Kudgus Rachel A. , Ijaz Heba , Liu Xiaowei , Minard Charles G. , Pawel Bruce R. , Maris John M. , Haas-Kogan Daphne A. , Voss Stephan D. , Berg Stacey L. , Reid Joel M. , Fox Elizabeth , Weigel Brenda J. 
Published: December 2019

Abstract

Purpose:
Adavosertib (AZD1775), an inhibitor of WEE1 kinase, potentiates replicative stress induced by oncogenes or chemotherapy. Antitumor activity of adavosertib has been demonstrated in preclinical models of pediatric cancer. This phase I trial was performed to define dose-limiting toxicities (DLT), recommended phase II dose (RP2D), and pharmacokinetics of adavosertib in combination with irinotecan in children and adolescents with relapsed or refractory solid tumors or primary central nervous system tumors.

Patients and Methods:
Using a 3+3 escalation design, five dose cohorts of the combination of adavosertib and irinotecan (50/70; 65/70; 65/90; 85/90; 110/90 mg/m2/day) delivered on days 1–5 of a 21-day cycle were studied. Pharmacokinetics and analysis of peripheral blood γH2AX was performed.

Results:
Thirty-seven patients were enrolled; 27 were evaluable. The median (range) age was 14 (2–20) years. Twenty-five (93%) received prior chemotherapy (median, three regimens) and 21 (78%) received prior radiotherapy. Eleven patients had a primary central nervous system (CNS) malignancy. Common toxicities were hematologic and gastrointestinal. Two patients receiving adavosertib (110 mg/m2) in combination with irinotecan (90 mg/m2) experienced dose-limiting grade 3 dehydration. A patient with Ewing sarcoma had a confirmed partial response and 2 patients (ependymoma and neuroblastoma) had prolonged stable disease (≥ 6 cycles). Pharmacokinetics of adavosertib were variable but generally dose proportional and clearance was lower in younger patients.

Conclusions:
Adavosertib (85 mg/m2) in combination with irinotecan (90 mg/m2) administered orally for 5 days was the MTD in children and adolescents with solid and CNS tumors.
Outcomes among Patients Treated with Renal Replacement Therapy during Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Study
Authors: Dado David N. , Ainsworth Craig R. , Thomas Sarah B. , Huang Benjamin , Piper Lydia C. , Sams Valerie G. , Batchinsky Andriy , Morrow Benjamin D. , Basel Anthony P. , Walter Robert J. , Mason Phillip E. , Chung Kevin K. 
Published: December 2019

<b><i>Background:</i></b> Extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) are modalities used in critically ill patients suffering organ failure and metabolic derangements. Although the effects of CRRT have been extensively studied, the impact of simultaneous CRRT and ECMO is less well described. The purpose of this study is to evaluate the incidence and the impact of CRRT on outcomes of patients receiving ECMO. <b><i>Methods:</i></b> A single center, retrospective chart review was conducted for patients receiving ECMO therapy over a 6-year period. Patients who underwent combined ECMO and CRRT were compared to those who underwent ECMO alone. Intergroup ­statistical comparisons were performed using Wilcoxon/Kruskal-Wallis and chi-square tests. Logistic regression was performed to identify independent risk factors for mortality. <b><i>Results:</i></b> The demographic and clinical data of 92 patients who underwent ECMO at our center were reviewed including primary diagnosis, indications for and mode of ECMO support, illness severity, oxygenation index, vasopressor requirement, and presence of acute kidney injury. In those patients that required ECMO with CRRT, we reviewed urine output prior to initiation, modality used, prescribed dose, net fluid balance after 72 h, requirement of renal replacement therapy (RRT) at discharge, and use of diuretics prior to RRT initiation. Our primary endpoint was survival to hospital discharge. During the study period, 48 patients required the combination of ECMO with CRRT. Twenty-nine of these patients survived to hospital discharge. Of the 29 survivors, 6 were dialysis dependent at hospital discharge. The mortality rate was 39.5% with combined ECMO/CRRT compared to 31.4% among those receiving ECMO alone (<i>p</i> = 0.074). Of those receiving combined therapy, nonsurvivors were more likely to have a significantly positive net fluid balance at 72 h (<i>p</i> = 0.001). A multivariate linear regression analysis showed net positive fluid balance and increased age were independently associated with mortality. <b><i>Conclusions:</i></b> Use of CRRT is prevalent among patients undergoing ECMO, with over 50% of our patient population receiving combination therapy. Fluid balance appears to be an important variable associated with outcomes in this cohort. Rates of renal recovery and overall survival were higher compared to previously published reports among those requiring combined ECMO/CRRT.
Reclamatórias em saúde recebidas pelo Ministério Público do Estado do Paraná: um estudo do CAOP de Proteção à Saúde Pública
Authors: Aragão Suéllyn Mattos de , Silva André Luis Cândido da , Ditterich Rafael Gomes , Kusma Solena Ziemer 
Published: December 2019

O objetivo do estudo foi evidenciar os principais desafios sanitários no Estado do Paraná nos anos de 2016 e 2017, a partir da análise das denúncias realizadas junto ao Ministério Público Estadual. A proposta foi instrumentalizar gestores e usuários do sistema público para o reconhecimento e o enfrentamento das necessidades prementes em saúde. Realizou-se um estudo, documental e qualitativo, por meio da organização e análise de dados do sistema de informação do Centro de Apoio Operacional das Promotorias de Justiça de Proteção à Saúde Pública. Na categorização, adotou-se cinco classes iniciais, preconizadas pelo serviço estudado. Posteriormente, procedeu-se ao reconhecimento das categorias finais correspondentes e à formulação de conceitos norteadores com base nos fundamentos do Direito Sanitário. Os resultados demonstraram predomínio de demandas pertencentes à categoria relacionada a medicamentos, insumos e procedimentos. Destacou-se, também, a categoria referente às ocorrências de má prática profissional. A pesquisa concluiu que a principal fragilidade do Sistema Único de Saúde no Estado do Paraná, denunciada ao Ministério Público estadual, foi o provimento de medicamentos. Com a constatação de que a problemática dominante apontada pelo estudo relaciona-se ao fornecimento de fármacos e, por conseguinte, às limitações da universalidade e da integralidade do sistema público sanitário, foram debatidas as variantes imbricadas nesses preceitos: indefinição sobre os limites do dever do Estado, no que se refere ao oferecimento de serviços e produtos; extensão e pretensão da política de assistência farmacêutica do Sistema Único de Saúde; interesses conflitantes entre Estado e mercado; desafios regulatórios; entre outros.
Shaping the Evolution of Regime Complex
Authors: Yu Hanzhi , Xue Lan 
Published: December 2019

Abstract
Regime complex has been widely recognized in many governance issues, but the evolutionary dynamics in regime complex are largely overlooked. This article explores the evolutionary dynamics by conducting a case study on the regime complex for human genetic data, which has evolved as an alternation between stable and unstable periods, known as punctuated equilibrium. Given that existing theories fail to explain the evolutionary pattern, a multiactor analysis framework is set up with the core argument that the evolution of regime complex is shaped by interactions between governance issues outside the regime complex, and a combination of actor power and institutional logics within them. Besides its specific contribution to the literature on regime complex, this article has general implications for research in global governance.
Providing for Global Security
Authors: Fung Courtney J. 
Published: December 2019

Abstract
A fundamental question facing global governance today is whether the UN peacekeeping regime can function with enough skilled troops to execute increasingly demanding and complicated mandates. The People’s Republic of China is informally thought of as a potential lead troop-contributing country. China typically deploys non-combat enabler troops, and recently began deploying combat troops, which may have to engage in live fire to defend the mandate. The risks and costs associated with dispatching combat troops challenge the benefits that China derives from supporting peacekeeping. I first establish China’s feedback mechanisms to facilitate simple and complex learning against China’s peacekeeping trajectory and motivations for participation. I then address the implications of China’s combat troop deployment, focusing on the UN Multidimensional Stabilization Mission in Mali and the UN Mission in South Sudan. The article draws insights from interviews with Chinese foreign policy elites and UN officials, and participant observation at the UN Department of Peacekeeping Operations.
Viewing Rome in the Latin Literature of the Ventennio Fascista: Francesco Giammaria’s Capitolium Novum
Authors: Bettegazzi Nicolò , Lamers Han , Reitz-Joosse Bettina 
Published: December 2019

Abstract
This article analyses Francesco Giammaria’s Capitolium Novum, a Latin poem describing a tour of the historic center of Rome in 1933, in its historical, architectural, and intellectual contexts. It offers a detailed analysis of three key sections of the poem, which deal with the Colosseum, the Arch of Constantine, and the Ara dei caduti fascisti respectively. The authors show how Giammaria’s poem responds to urbanistic interventions in the city center during the ventennio, and specifically to the Fascist ‘recoding’ of the city as the ‘Third Rome’, with a narrative emphasizing the historically layered nature of Rome. Giammaria offers his own interpretation of the respective importance and interrelation of the city’s historic layers: the rhetoric of his poem is aimed at superimposing Catholic Rome over pagan Rome, and at framing all historical layers of the city, including the Fascist one, as part of its Christian mission and destiny. Thus, Capitolium novum resonates with efforts of intellectuals gathered around Carlo Galassi Paluzzi’s Istituto di Studi Romani, who aimed to promote a cultural reconciliation between Fascism and Catholicism.
Fascism, National Socialism, and the 1939 New York World’s Fair
Authors: Fortuna James J. 
Published: December 2019

Abstract
This article considers the involvement of Fascist Italy and Nazi Germany at the 1939 New York World’s Fair. It considers the form, function, and content of the Italian Pavilion designed for this fair and asserts that the prefabricated monumental structure would be best interpreted, not in isolation, but as an element of the larger architectural conversation which continued to unfold across contemporary fascist Europe. Such reconsideration of this building makes it possible to evaluate the relationship between Fascist design, the assertion of political will, and the articulation of national identity and cultural heritage within a larger, transnational context. The author also investigates the American exhibition committee’s earnest and persistent, yet ultimately unheeded, solicitation of Nazi German participation and argues that motives behind German withdrawal from this event had as much to do with the threat of popular protest as economic pressure.
A Meteorological Study of the Port Hills Fire, Christchurch, New Zealand
Authors: Pretorius Ilze , Sturman Andrew , Strand Tara , Katurji Marwan , Pearce Grant 
Published: December 2019

AbstractIn February 2017, a wildfire occurred in the Port Hills on the southern boundary of Christchurch city in New Zealand. It was one of the country’s most severe fires of the last decade in terms of the scale of evacuation, infrastructure damage, and property loss. On the third day of the fire, fire behavior was unexpectedly active, and two rapid downhill fire-spread events took place, creating a dangerous situation for firefighters. The aim of this paper is to explore the atmospheric processes that influenced the fire behavior at a range of meteorological scales, from the synoptic to meso- and microscales. Meteorological and fire data analyzed include observed data together with model simulations of weather conditions at different scales: 1) the Weather Research and Forecasting (WRF) numerical weather prediction model, which provided the regional context of the fire; and 2) the California Meteorological (CALMET) diagnostic model, which was used to undertake a higher-resolution investigation of atmospheric processes near the fire. Results indicate that the fire was not strongly seasonally influenced. Instead, it appears the fire conditions were the effect of a specific combination of synoptic weather conditions and local meteorological conditions. The first rapid downhill fire-spread event was the result of airflow interaction with the intricate terrain of the Port Hills under stable nocturnal conditions. The second downhill fire-spread event bears similarities to vorticity-driven lateral spread, because the downhill component of the spread happened on a broad fire flank perpendicular to the surface wind direction and characteristic pyrocumulus convection occurred.
Time-Dependent Propagation of Tsunami-Generated Acoustic–Gravity Waves in the Atmosphere
Authors: Wu Yue , Llewellyn Smith Stefan G. , Rottman James W. , Broutman Dave , Minster Jean-Bernard H. 
Published: December 2019

Abstract
Tsunami-generated linear acoustic–gravity waves in the atmosphere with altitude-dependent vertical stratification and horizontal background winds are studied with the long-term goal of real-time tsunami warning. The initial-value problem is examined using Fourier–Laplace transforms to investigate the time dependence and to compare the cases of anelastic and compressible atmospheres. The approach includes formulating the linear propagation of acoustic–gravity waves in the vertical, solving the vertical displacement of waves and pressure perturbations numerically as a set of coupled ODEs in the Fourier–Laplace domain, and employing den Iseger’s algorithm to carry out a fast and accurate numerical inverse Laplace transform. Results are presented for three cases with different atmospheric and tsunami profiles. Horizontal background winds enhance wave advection in the horizontal but hinder the vertical transmission of internal waves through the whole atmosphere. The effect of compressibility is significant. The rescaled vertical displacement of internal waves at 100-km altitude shows an arrival at the early stage of wave development due to the acoustic branch that is not present in the anelastic case. The long-term displacement also shows an O(1) difference between the compressible and anelastic results for the cases with uniform and realistic stratification. Compressibility hence affects both the speed and amplitude of energy transmitted to the upper atmosphere because of fast acoustic waves.
A Multiresolution Ensemble Hybrid 4DEnVar for Global Numerical Prediction
Authors: Kay Junkyung , Wang Xuguang 
Published: December 2019

Abstract
A multiresolution ensemble (MR-ENS) method is developed to resolve a wider range of scales of the background error covariance (BEC) in the hybrid four-dimensional ensemble–variational (4DEnVar) while saving computational costs. MR-ENS is implemented in the NCEP Global Forecast System (GFS) gridpoint statistical interpolation (GSI) hybrid 4DEnVar. MR-ENS generates analysis increment by incorporating high-resolution static BEC and flow-dependent ensemble BECs from both high and low resolutions. MR-ENS is compared with three 4DEnVar update approaches: 1) the single-resolution (SR)-Low approach where the analysis increments are generated from the ensemble BEC and the static BEC at the same low resolution; 2) the dual-resolution (DR) approach where the analysis increment is generated using the high-resolution static BEC and low-resolution ensemble BEC; and 3) the SR-High approach, which is the same as 1) except that all covariances are at high-resolution. Experiments show that MR-ENS improves global and tropical cyclone track forecasts compared to SR-Low and DR. Inclusion of the high-resolution ensemble leads to increased background ensemble spread, better fitting of the background to observations, increased effective ranks, more accurate ensemble error correlation, and increased power of analysis increment at small scales. The majority of the improvement of MR-ENS relative to SR-Low is due to the partial use of high-resolution background ensemble. Compared to SR-High, MR-ENS decreases the overall cost by about 40% and shows comparable global and tropical cyclone track forecast performances. Diagnostics show that particularly in the tropics, MR-ENS improves the analysis increment over a wide range of scales and increases the effective rank of the ensemble BEC to the degree comparable to SR-High.
Risk factors of postoperative low back pain for low-grade isthmic spondylolisthesis: a retrospective study
Authors: Guan Fulin , Yin Hongna , Zhu Lin , Zhang Zhizhuang , Gao Qichang , Shao Tuo , Tang Weilong , Guan Guofa , Chen Ming , Chi Zhiyong , Gu Jiaao , Yu Zhange 
Published: December 2019

Objective To investigate the risk factors of postoperative low back pain (LBP) following posterior lumbar interbody fusion (PLIF) surgery for low-grade isthmic spondylolisthesis (IS). Methods This retrospective study enrolled patients with IS that underwent PLIF between January 2011 and January 2016. Demographic, clinical, surgical and radiological characteristics were analysed to determine associations between these characteristics and LBP as measured using a visual analogue scale (VAS) pain score. Results A total of 192 patients were enrolled in the study. The mean VAS pain score of LBP decreased significantly after surgery. The mean preoperative VAS pain score was significantly greater in patients with symptoms of ≤3 years duration compared with those with symptoms lasting >3 years. The postoperative VAS pain score was significantly lower in patients with grade 1 slippage compared with those with grade 2 slippage. There was a significant correlation between preoperative to postoperative change of VAS pain score and postoperative disc height ( r = 0.99). Conclusion PLIF significantly improved LBP in patients with low-grade IS, although patients still reported some postoperative LBP. The grade of slippage was a risk factor for postoperative LBP. Restoring the disc height appeared to improve LBP.
Meta-analysis of the prognostic significance of FOXC2 in various tumors
Authors: Xu Bixia , Tian Yun , Liu Lin 
Published: December 2019

Objective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019. Results The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74–2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44–4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49–2.50) than patients lacking FOXC2. Conclusions The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future.
Biopolitics Multiple: Migration, Extraction, Subtraction
Authors: Aradau Claudia , Tazzioli Martina 
Published: December 2019

This article proposes ‘biopolitics multiple’ as an approach to the heterogeneity of biopolitical technologies deployed to govern migration today. Building on work that has started to develop analytical vocabularies to diagnose biopolitical technologies that work neither by fostering life nor by making people die in a necropolitical sense, it conceptualises ‘extraction’ and ‘subtraction’ as two such technologies that take ‘hold’ of migrants’ lives today. Extraction, explored in the article through a focus on borderzones in Greece, captures the imbrication of biopolitics and value through the ‘outside’ creation of the economic conditions of data circulation. Subtraction, which is analysed in this article through a focus on Calais, captures the practices of (partial) non-governing by taking material and legal terrain away from migrants and reconfiguring convoluted geographies of (forced) hyper-mobility. This move allows us to understand the governmentality of migration beyond binary oppositions such as ‘making live/letting die’, biopolitics/necropolitics and inclusion/exclusion. Biopolítica múltiple: migración, extracción, sustracción
Ictal neck pain investigated in the interictal state – a search for the origin of pain
Authors: Hvedstrup Jeppe , Kolding Lærke Tørring , Younis Samaira , Ashina Messoud , Schytz Henrik Winther 
Published: December 2019

Background Neck pain is reported in more than 50% of migraine patients during migraine attacks and may be an important source to migraine pain. Objectives To investigate phenotypical differences between migraine patients with and without ictal neck pain in the interictal phase. Additionally, to prospectively examine the association between pericranial muscle tenderness and the impending migraine attack. Methods Migraine patients (n = 100) and controls (n = 46) underwent a semi-structured interview and sensory testing interictally. Pericranial muscle tenderness was determined using total tenderness score and local tenderness score. The occurrence of migraine attacks was then prospectively recorded for the following seven days. Results Patients with ictal neck pain had increased tenderness of pericranial neck muscles compared to migraine patients without ( p = 0.023). Ictal neck pain was not associated with migraine localization, tension-type headache, or markers of central sensitization. Prospective data of 84 patients showed that tenderness of trigeminal sensory innervated muscles increased the migraine attack rate ( p = 0.035). Conclusion The distinction of migraine patients based on the occurrence of ictal neck pain could indicate migraine subtypes and possible involvement of peripheral tissue in the pathophysiology. Whether treatment responses differ among these groups would be fascinating. Additionally, we found that cephalic muscle tenderness is a risk factor for an impending migraine attack.