bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hamlet without the Prince of Denmark: Bringing Capitalism back into the ‘New’ History of Capitalism
Authors: Kershaw Paul V. 
Published: March 2020

AbstractA growing number of historians are self‐identifying as historians of capitalism, a new subfield within the discipline, and have produced research on interesting new questions that transcend the subfields of economic, business, social, cultural, and political history. Ironically, what is missing from the “new” history of capitalism is any serious engagement with the new subfield's central character—capitalism, which instead is simply assumed despite being a contested concept. The implications are not trivial and include making unfalsifiable claims, unwittingly implying that capitalism is totalizing, and reproducing rather than exposing ahistorical understandings of the concept.
Transmission of hepatitis C virus in HIV‐positive and PrEP‐using MSM in England
Authors: Bradshaw Daniel , Vasylyeva Tetyana I. , Davis Chris , Pybus Oliver G. , Thézé Julien , Thomson Emma C. , Martinello Marianne , Matthews Gail V. , Burholt Ruth , Gilleece Yvonne , Cooke Graham S. , Page Emma E. , Waters Laura , Nelson Mark 
Published: March 2020

AbstractWe sought to characterize risk factors and patterns of HCV transmission amongst men who have sex with men (MSM). MSM with recently acquired HCV (AHCV) were prospectively recruited ('clinic cohort') between January and September 2017. Clinical data and risk behaviours were identified and blood obtained for HCV whole genome sequencing. Phylogenetic analyses were performed, using sequences from this cohort and two other AHCV cohorts, to identify transmission clusters. Sixteen (40.0%) men in the clinic cohort were HIV‐negative MSM. HIV‐negative MSM were younger than HIV‐positive MSM; most (81.3%) had taken HIV PrEP in the preceding year. Eighteen men (45.0%) reported injection drug use; most (34, 85.0%) reported noninjection drug use in the last year. Most in both groups reported condomless anal sex, fisting and sex in a group environment. Few (7, 17.5%) men thought partners may have had HCV. There were 52 sequences in the HCV genotype 1a phylogeny, 18 from the clinic cohort and 34 from other AHCV cohorts; 47 (90.4%) clustered with ≥1 other sequence. There were 7 clusters of 2‐27 sequences; 6 clusters contained HIV‐negative and HIV‐positive MSM and 1 cluster only HIV‐positive MSM. Four of these clusters were part of larger clusters first described in 2007. PrEP‐using MSM are at risk of HCV, sharing similar risk factors to HIV‐positive MSM. Phylogenetics highlights that PrEP‐using and HIV‐positive MSM are involved in the same HCV transmission networks. Few men demonstrated HCV awareness and risk reduction strategies should be expanded.
The relationship between body shape, body size and locomotor mode in extant lepidosaurs
Authors: Grinham L. R. , Norman D. B. 
Published: March 2020

AbstractDespite historic work, the mechanisms and evolutionary drivers associated with the adoption of a facultatively bipedal locomotor mode in extant lepidosaurs are unclear. Recent work has provided insights into the biomechanical triggers of bipedal locomotion, but the associated anatomies are yet to be fully understood, particularly with regard to body size across Lepidosauria. Using a dataset derived from museum specimens, representing a range of lepidosaur body shapes, we highlight the differences between obligate quadrupeds and facultative bipeds within this group and demonstrate the value of non‐caudal skeletal material in identifying facultative bipeds using osteology alone. We use multiple statistical approaches to identify trends across locomotor modes relative to body size. Body size has a significant effect upon body proportions across the two locomotor modes, especially in the hindlimbs. Forelimb lengths do not differ significantly across locomotor modes for animals of similar body size, but distal hindlimbs are significantly longer in facultative bipeds. Interestingly, femoral length does not differ across locomotor modes of a similar body size. Our findings contrast with historical tropes and are significant for future work attempting to identify the factors driving the evolution of a facultatively bipedal locomotor mode in Lepidosauria.
Female concave‐eared torrent frogs prefer smaller males
Authors: Zhang F. , Yuan C. , Feng A. S. 
Published: March 2020

AbstractMate choice is a natural selection mechanism whereby the traits of select members of a population are passed on to their offspring. We hypothesized that, for stream‐dwelling anurans, females might prefer males with smaller body size and higher call frequency as their vocal calls are more conspicuous in the species’ habitat featuring intense but predominantly low‐frequency stream noise. To test this hypothesis, we first measured the body size of amplectant male concave‐eared torrent frogs (Odorrana tormota) in the field, a species with demonstrated ability of ultrasonic communication. Our field observation showed that, on average, amplectant males had smaller body size compared to that of non‐amplectant males (P < 0.05), an unusual finding among anurans. We next performed two‐choice amplexus experiments by pairing a female with two males in an aquarium indoors. Results of laboratory experiments similarly revealed female’s preference for males with smaller body sizes. Additionally, we recorded and analyzed the advertisement calls of 33 males and confirmed that their call frequency was inversely related to the body size as expected. Together, our studies showed that, for O. tormota, smaller males with higher call frequencies had higher mating success over bigger rivals, that is, females prefer smaller males.
Pluractionality: A cross‐linguistic perspective
Authors: Mattiola Simone 
Published: March 2020

AbstractThis paper aims to give a cross‐linguistic overview of pluractionality. Pluractionality is defined as a structural modification of the verb indicating the presence of multiple events. The paper first investigates the functions associated with pluractional markers in the languages of the world and classifies them into core and additional functions. I then present the most frequent marking strategies that the languages adopt in order to encode pluractionality and briefly discuss the morphological nature of one in particular (i.e., lexical alternation), as well as the formal identification of participant plurality. Finally, I examine the grammatical status of pluractionality in a cross‐linguistic perspective, taking the most recent typological literature into consideration. I conclude that “pluractionality” cannot be theoretically conceived as a unique, cross‐linguistically valid category but should rather be regarded as a label, which indicates different phenomena in different languages, useful for typological comparison but not reflecting any kind of pre‐established grammatical category.
Improving self‐care efficacy and quality of life with a self‐management program among patients with chronic obstructive pulmonary disease: A quasi‐experimental study
Authors: Liou Huey‐Ling , Huang Yu‐Tai , Lai Zi‐Yi , Tsou Yin‐Yin , Tsai Ya‐Chi , Yu Hsiao‐Hui , Chen Mei‐shuang 
Published: March 2020

AbstractSelf‐management helps patients understand their illnesses and learn about disease‐related skills so they can better manage their situation. However, published studies on the effectiveness of self‐management for chronic obstructive pulmonary disease (COPD) are heterogeneous. Quasi‐experimental design was used to investigate the effectiveness of a self‐management program in self‐care efficacy and quality of life in patients with COPD. Sixty participants who had experienced COPD were assigned to control group (usual care) or experimental group (self‐care program) (1:1 ratio) according to a purposeful sampling at a Medical Center in Taiwan. The Medical Research Council dyspnea scale, the COPD Self‐Efficacy Scale, the Clinical COPD Questionnaire were used to analyze data. The Medical Research Council dyspnea scale was more significant improvement in the 2 months after discharge in the experimental group than in the control group. The COPD Self‐Efficacy Scale and Clinical COPD Questionnaire scores in the experimental group within 3 months after discharge were significantly improved compared with the control group. These findings demonstrate the application and initial effect of this self‐management program.
Arthroscopic Anatomical Repair of Anterior Talofibular Ligament for Chronic Lateral Instability of the Ankle: Medium‐ and Long‐Term Functional Follow‐Up
Authors: Feng Shi‐ming , Sun Qing‐qing , Wang Ai‐guo , Chang Bu‐qing , Cheng Jian 
Published: March 2020

ObjectiveTo evaluate the functional outcomes of arthroscopic anatomical repair of anterior talofibular ligament (ATFL) in the treatment of chronic lateral ankle instability (CLAI) during medium‐ and long‐term follow‐up.MethodsFrom September 2014 to August 2017, the data of 37 patients (23 males, 14 females; 12 left ankles, 25 right ankles) aged between 21 and 56 years, with an average age of 32.17 ± 6.35 years, presenting with CLAI, was retrospectively analyzed. Among them, 32 injuries were caused by sprain and five injuries were caused by car accidents. The course of the disease lasted for 12 to 60 months, with an average of 26.07 ± 13.29 months. All patients had intact skin around the ankle and no skin lesions. All patients underwent arthroscopic anatomical repair of ATFL, with the fixation of one to two anchors. Pre‐ and post‐operative visual analogue scales (VAS), the American Orthopaedic Foot and Ankle Society Ankle‐Hindfoot Score (AOFAS), and the Karlsson Ankle Functional Score (KAFS) were compared to evaluate the curative effect of the operation.ResultsThe operation was successful in all 37 cases. The operation time ranged from 40 to 75 min, with an average of 51.25 ± 11.49 min. After surgery, all incisions healed in stage I and there were no complications such as nerve, blood vessel and tendon injury, implant rejection, or suture rejection. Hospital stays of postoperative patients were 3 to 5 days, with an average of 3.77 ± 1.36 days. All patients were followed for 24 to 45 months, averaging 33.16 ± 10.58 months. For three patients with CLAI combined with mild limitation of subjective ankle movement, joint activity was normal after rehabilitation function exercise and proprioceptive function training for 2 months. At the final follow‐up, ankle pain had disappeared completely. The ankle varus stress test and ankle anterior drawer test were both negative. Range of joint motion was good. There was no lateral instability of the ankle and all patients returned to normal gait. The mean VAS score decreased to 1.12 ± 0.13, the AOFAS score increased to 92.53 ± 4.87, and the KAFS score increased to 93.36 ± 6.15. All the follow‐up indexes were significantly different from those before surgery.ConclusionArthroscopic anatomical repair of ATFL for CLAI is precise, with less surgical trauma and reliable medium‐ and long‐term effect.
Stepwise approach to induce infrequent premature ventricular complex using bolus isoproterenol and epinephrine infusion
Authors: Shinoda Yasutoshi , Komatsu Yuki , Nogami Akihiko , Igarashi Miyako , Yamasaki Hiro , Sekiguchi Yukio , Aonuma Kazutaka , Ieda Masaki 
Published: March 2020

AbstractBackgroundPaucity of a premature ventricular complex (PVC) during ablation procedures may occur and be associated with a lower success rate. Isoproterenol (ISP) injections are commonly used to induce PVC; however, the induced tachycardia sometimes prevents the appearance of PVC. Epinephrine (EPI) administration may be an alternative strategy to induce PVC due to its smaller effect on heart rate (HR). This study sought to examine the electrophysiological impact of EPI injection, with a stepwise induction protocol, for infrequent intraprocedural PVC.MethodsWe studied 78 consecutive patients who underwent catheter ablation of idiopathic frequent PVC. If no PVC was observed at the beginning of the procedure, ISP (10 µg) was injected. If clinical PVC was not induced by ISP administration, EPI (10 µg) was injected.ResultsOf 18 patients without PVC at baseline, ISP injection induced PVC in five patients. Of the remaining 13 patients, EPI injection successfully induced PVC in seven patients (53%). The maximum HR and increments of HR after EPI injection were significantly lower than those after ISP injection (99 ± 15 vs 137 ± 15 bpm, P = .001; 22 ± 10 vs 53 ± 12 bpm, P < .001, respectively). There were no complications related to the induction protocol.ConclusionEPI injection following ISP injection is an effective and safe stepwise approach for the induction of infrequent PVC in the electrophysiology laboratory. It is hypothesized that α‐ and β‐adrenergic receptor stimulation by EPI injections, with reduced HR acceleration compared to that with ISP injections, may result in the successful induction of PVC.
Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative‐Mediated Intraperitoneal Photodynamic Therapy in a Canine Model
Authors: Cramer Gwendolyn , Lewis Robert , Gymarty Ashley , Hagan Sarah , Mickler Michela , Evans Sydney , Punekar Salman R. , Shuman Lee , Simone Charles B. , Hahn Stephen M. , Busch Theresa M. , Fraker Douglass , Cengel Keith A. 
Published: March 2020

AbstractPeritoneal carcinomatosis (PC) can occur as an advanced consequence of multiple primary malignancies. Surgical resection, radiation or systemic interventions alone have proven inadequate for this aggressive cancer presentation, since PC still has a poor survival profile. Photodynamic therapy (PDT), in which photosensitive drugs are exposed to light to generate cytotoxic reactive oxygen species, may be an ideal treatment for PC because of its ability to deliver treatment to a depth appropriate for peritoneal surface tumors. Additionally, epidermal growth factor receptor (EGFR) signaling plays a variety of roles in cancer progression and survival as well as PDT‐mediated cytotoxicity, so EGFR inhibitors may be valuable in enhancing the therapeutic index of intraperitoneal PDT. This study examines escalating doses of benzoporphyrin derivative (BPD)‐mediated intraperitoneal PDT combined with the EGFR‐inhibitor cetuximab in a canine model. In the presence or absence of small bowel resection (SBR) and cetuximab, we observed a tolerable safety and toxicity profile related to the light dose received. Additionally, our findings that BPD levels are higher in the small bowel compared with other anatomical regions, and that the risk of anastomotic failure decreases at lower light doses will help to inform the design of similar PC treatments in humans.
Infrared‐A Irradiation‐induced Inhibition of Human Keratinocyte Proliferation and Potential Mechanisms
Authors: Shimizu Syota , Aoki Akihiro , Takahashi Takuya , Harano Fumiki 
Published: March 2020

AbstractInfrared‐A (IRA), which can penetrate deeply into the human skin, is a major component of solar radiation and is recognized to promote photoaging of human dermis. To our knowledge, however, the cellular and molecular consequences of human epidermis exposure to IRA have not been clarified. Thus, we investigated whether IRA inhibits the proliferation of normal human epidermal keratinocytes (NHEKs). IRA irradiation ed in cell cycle arrest at G1 and a dose‐dependent reduction in the proliferation of NHEKs. We found that mechanistic target of rapamycin complex 1 (mTORC1) was initially inactivated during IRA irradiation due to the formation of stress granules (SGs), and this inactivation was maintained for at least 6 h after irradiation due to Akt dephosphorylation. Furthermore, repeated exposure of human skin equivalents to IRA led to marked thinning of the epidermal cell layer. In conclusion, IRA irradiation inhibits mTORC1 activity possibly through two molecular mechanisms involving SG formation in the early‐phase and subsequent Akt dephosphorylation. This sequential mechanism seems to cause G1 cell cycle arrest and a reduction in cell proliferation, supporting the hypothesis that the decreased proliferation of basal keratinocytes that occurs during skin aging might be partly attributable to IRA radiation.
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Authors: Grigalavicius Mantas , Mastrangelopoulou Maria , Arous Delmon , Juzeniene Asta , Ménard Mathilde , Skarpen Ellen , Berg Kristian , Theodossiou Theodossis A. 
Published: March 2020

AbstractIn the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and T98G spheroids as shown by flow cytometry on the single cell level. Moreover, cerco is efficiently internalized by cells throughout the spheroid as shown by confocal microscopy, for all three cell lines. Despite their higher cerco uptake, U87 spheroids show the least vulnerability to cerco‐PDT, in contrast to the other two cell lines (T47D and T98G). While 300 μm diameter spheroids consistently shrink and become necrotic after cerco PDT, bigger spheroids (>500 μm) start to regrow following blue‐light PDT and exhibit high viability. Cerco‐PDT was found to be effective on bigger spheroids reaching 1mm in diameter especially under longer exposure to yellow light (~590 nm). In terms of metabolism, T47D and T98G undergo a complete bioenergetic collapse (respiration and glycolysis) as a result of cerco‐PDT. U87 spheroids also experienced a respiratory collapse following cerco‐PDT, but retained half their glycolytic activity.
Incorporation in Lipid Microparticles of Acid Red 87, a Colorant Used in Tattoo Inks: Effect on Photodegradation Under Simulated Sunlight and Laser Radiation
Authors: Scalia Santo , Dozzo Annachiara , Magli Sofia , Scarcella Giuseppe 
Published: March 2020

AbstractTattoo colorants decompose under solar radiation and when exposed to laser light for their removal, leading to the accumulation in the dermis of toxic products. Aim of this study was to develop lipid microparticles (LMs) loaded with the colorant, Acid Red 87 (C.I. 45380) used in tattoo inks, and to investigate the effect of this system on the photostability of the colorant under simulated sunlight or laser irradiation. LMs loaded with C.I. 45380 were prepared by melt emulsification using tristearin and phosphatidylcholine as excipients. They were characterized by optical microscopy, laser diffraction, X‐ray diffraction and release studies. Free C.I. 45380 and the colorant‐loaded LMs were irradiated with a solar simulator or a Q‐switched laser. Irradiation with a solar simulator demonstrated that photodecomposition of C.I. 45380 was markedly reduced by incorporation of the dye in the LMs, from 20.5 ± 4.6% to 1.3 ± 1.8%. Conversely, the laser‐induced degradation of the colorant (30.1 ± 6.6%) was not significantly influenced by encapsulation in the LMs (the encapsulated C.I. 45380 loss was 27.4 ± 5.5%). Incorporation of C.I. 45380 in lipid microparticles enhances the photostability under sunlight of tattoo inks containing this colorant, without affecting its laser‐induced degradation and hence laser removal efficiency.
The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi
Authors: Henning Alischa , Clift Sarah Jane , Leisewitz Andrew Lambert 
Published: March 2020

AbstractTo provide useful information based on the macropathology, histopathology and immunohistochemical investigation in the spleens of dogs with Babesia rossi infection. Control spleens were collected from four healthy dogs euthanized for welfare reasons. Nine dogs that died naturally because of a mono‐infection with Babesia rossi were selected for the diseased group. One haematoxylin‐and‐eosin–stained section of splenic tissue from each of the infected and control dogs was examined under the light microscope. Immunohistochemical markers were applied to characterize different immunocyte populations. The application of analytic software enabled semi‐quantitative comparison of leucocyte subpopulations. Routine splenic histopathology revealed diffuse intermingling of white and red pulp from infected dogs with a clear loss of distinction between these zones. Immunohistochemistry revealed an increase in the proportion of tissue resident and bone marrow origin macrophages in the infected spleens. Apart from a few remnant lymphocytes within the peri‐arteriolar lymphatic sheaths and follicles, the majority of the immunocytes redistributed to the red pulp, supporting the observation of white and red pulp intermingling. The majority of our findings are in agreement with histomorphological descriptions of the spleen in a variety of noncanid mammalian hosts with lethal malaria or babesiosis.
Malignant mesothelioma cells secrete natriuretic peptides: Data and diagnostic clinical implications
Authors: Tsolaki Vasiliki , Zarogiannis Sotirios , Zygoulis Paris , Kalomenidis Ioannis , Jagirdar Rajesh , Makris Demosthenes , Daniil Zoe , Magkouta Sofia , Triantafyllou Ioannis , Papanikolaou John , Gourgoulianis Konstantinos I. , Zakynthinos Epaminondas 
Published: March 2020

ABSTRACTBackground and objectiveMesothelial cells and cardiomyocytes have shared embryonic mesodermal origin. Cardiomyocytes release BNP under stretch. We searched whether malignant mesothelioma cells also secrete BNP and if so, this has a meaningful impact.MethodsPart I: Prospectively, patients with pleural lesions on CT having malignant mesothelioma effusions (MME, n = 13) were compared to patients with malignant effusions with pleural lesions (MEa, n = 14). Age‐matched patients with ME without pleural lesions (MEb, n = 16) and non‐malignant effusions (NME, n = 25) were analysed. Part II: Retrospectively, samples from patients with mesothelioma (n = 14), lung cancer (n = 8) or heart failure (n = 9) were used. BNP was measured in pleural fluid and blood/plasma. Part III: BNP was assessed in the culture supernatants of benign (MeT‐5A) and malignant mesothelioma cell lines (M14K‐epithelioid, MSTO‐biphasic and ZL34‐sarcomatoid) (n = 10 per cell line in three different biological replicates).ResultsIn vitro, BNP concentration was significantly higher in the supernatant of all malignant cell lines than benign ones (P < 0.01), denoting BNP's production from the former. The pleural fluid to blood BNP ratio in MME was extremely high in Part I and Part II subjects (28.3 ± 12.1 and 25.9 ± 8.6, respectively) versus 1.1 ± 0.3 and 0.4 ± 0.1 in Part I ME and NME, respectively (P < 0.0001), and 0.8 ± 0.1 and 0.4 ± 0.1 in Part II ME and NME, respectively (P < 0.0001). BNP ratio ≥2.11 in Part I had 92% sensitivity and 94.5% specificity for MME (P < 0.0001).ConclusionBNP is secreted from malignant mesothelial cells. In clinical practice, the pleural fluid to blood BNP ratio can help in the diagnosis of malignant mesothelioma.