bluuebunny/crossref_metadata_2025_split huggingface dataset:
Travoprost Intracameral Implant: A Review on the Novel Treatment Modality for Open-Angle Glaucoma and Ocular Hypertension
Authors: Huston Jessica , Paauw Mark , Orey Dontia , Centner Aliya , Hasan Azeem , Shetty Rajesh , Freidl Kathryn , Goldfaden Rebecca 
Published: December 2024

Objective: This article reviews the published data encompassing the development, pharmacology, efficacy, and safety of travoprost, intracameral implant, a treatment for reduction of intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension. Data Sources: A literature search was conducted from drug discovery until September 2024 through PubMed, MEDLINE, and National Institutes of Health Clinical Trials Registry utilizing the following search terms: iDose, travoprost, intracameral implant, OTX-TIC, open-angle glaucoma, and ocular hypertension. Study Selection and Data Extraction: All relevant English-language studies, or studies that could be appropriately translated into English, containing the pharmacology, pharmacokinetics, safety, and efficacy of travoprost intracameral implant were selected for review. Data Synthesis: Travoprost implants showed significant reductions in IOP compared with other treatment options with fewer limitations often associated with topical medications resulting in travoprost implant patients favoring reduced concomitant use of topical IOP-lowering medications (with 81% of patients being medication free). Relevance to Patient Care and Clinical Practice in Comparison with Existing Drugs: Due to limited compliance with topical treatment modalities, the travoprost implant presents a promising alternative pathway for drug delivery. With a duration of 3 years and removal of the need for patient dexterity and application compliance, the travoprost implant serves an unmet need for patients and prescribers. Conclusion: Travoprost intracameral implant is a safe and effective delivery system for intracameral travoprost administration for patients with OAG or ocular hypertension.
The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale
Authors: Esin Fatma , Ince Hüseyin Sefa , Aktürk Semih , Citekci Fahrettin Tugrul , Celik Aykan , Kocabas Ugur , Kiris Tuncay , Karaca Mustafa 
Published: December 2024

Objective This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cryptogenic stroke (CS) in patients diagnosed with patent foramen ovale (PFO) using transesophageal echocardiography (TEE). Methods A retrospective, single-center study was conducted at a tertiary education and research hospital from January 2015 to December 2023. The study population included 1017 consecutive patients with sinus rhythm diagnosed with PFO, of whom 210 had CS. The TyG Index was calculated using triglyceride and fasting glucose levels. Results Patients with CS were older (47.53 ± 12.34 years) compared to control group (44.40 ± 17.82 years, p = .005). The proportion of males was higher in the CS group (56.2%) compared to the control group (48.3%, p = .042). Laboratory findings revealed higher TyG Index (8.87 ± 0.51 vs 8.63 ± 0.55, p < .001) in patients with CS. TyG Index was an independent predictor of CS in patients with PFO (OR: 2.832, 95%CI: 1.979-4.053 p < .001). Conclusion Elevated TyG Index levels was associated with CS in patients with PFO. The TyG index may serve as a useful biomarker for assessing CS risk in this population.
Prediction of Human Papillomavirus-Host Oncoprotein Interactions Using Deep Learning
Authors: Santa Sheila , Kwofie Samuel Kojo , Agyenkwa-Mawuli Kwasi , Quaye Osbourne , Brown Charles A , Tagoe Emmanuel A 
Published: December 2024

Background: Human papillomavirus (HPV) causes disease through complex interactions between viral and host proteins, with the PI3K signaling pathway playing a key role. Proteins like AKT, IQGAP1, and MMP16 are involved in HPV-related cancer development. Traditional methods for studying protein-protein interactions (PPIs) are labor-intensive and time-consuming. Computational models are becoming more popular as they are less labor-intensive and often more efficient. This study aimed to develop a deep learning model to predict interactions between HPV and host proteins. Method: To achieve this, available HPV and host protein interaction data was retrieved from the protocol of Eckhardt et al and used to train a Recurrent Neural Network algorithm. Training of the model was performed on the SPYDER (scientific python development environment) platform using python libraries; Scikit-learn, Pandas, NumPy, and TensorFlow. The data was split into training, validation, and testing sets in the ratio 7:1:2, respectively. After the training and validation, the model was then used to predict the possible interactions between HPV 31 and 18 E6 and E7, and host oncoproteins AKT, IQGAP1 and MMP16. Results: The model showed good performance, with an MCC score of 0.7937 and all other metrics above 88%. The model predicted an interaction between E6 and E7 of both HPV types with AKT, while only HPV31 E7 was shown to interact with IQGAP1 and MMP16 with confidence scores of 0.9638 and 0.5793, respectively. Conclusion: The current model strongly predicted HPVs E6 and E7 interactions with PI3K pathway, and the viral proteins may be involved in AKT activation, driving HPV-associated cancers. This model supports the robust prediction of interactomes for experimental validation.
Does early childhood multilingualism lead to enhanced executive functioning in early adulthood? A study examining inhibitory control (Stroop effect) in Swedish university students
Authors: Dvorak Martin 
Published: December 2024

Aims and objectives: The paper describes a study whose objective was to find whether there are any differences in inhibitory control measured with the Stroop test between Swedish early childhood (EC) monolingual and EC (bi-) multilingual university students in the language which is not their EC language and whether one can observe a relationship between the perceived proficiency in the subjects’ mother tongues and their Stroop Effect. Methodology: The analyses were conducted on a cohort of 105 students (41 EC monolinguals and 64 EC multilinguals) who took the Stroop test, the results of which (Stroop Effect) were compared for both the groups. A comparison was also made for multilinguals’ perceived proficiency in their mother tongues. Data and analysis: The data obtained via questionnaires and from a computerized version of the Stroop test were compared for EC monolinguals/EC multilinguals and evaluated statistically. Findings/conclusion: The results show no statistically significant difference in the inhibitory control measured by the Stroop test between the EC monolinguals and EC multilinguals. The only significant difference the analysis found between the groups is in reaction times, as the EC multilinguals reacted faster in both congruent and incongruent conditions. The analysis conducted among the EC multilinguals does not indicate any relationship between the perceived proficiency in their mother tongues and Stroop effect. Originality and implication: The findings contribute to a recent debate questioning cognitive early adulthood advantages of being an EC multilingual. Unlike the majority of other studies investigating inhibitory control, the Stroop test in this study was conducted in young adults and in the language (learnt at school and through extracurricular activities) in which all the students were on approximately the same proficiency level. The findings also bear relevance to future research on the relationship between inhibitory control and academic performance in young adults.
Axisymmetric cavity noise control using passive protrusion
Authors: Baskaran Kabilan , Srinivasan Kothandaraman 
Published: December 2024

This paper introduces a passive protrusions to reduce undesirable structural loading and high-amplitude noise radiation in axisymmetric cavities, are common in industries, including pipelines and aerospace. A comprehensive experimental investigation of the pipe-cavity noise control system is conducted, exploring various protrusion locations and lengths at different Nozzle Pressure Ratios (NPRs). The study examines protrusions placed at the leading, trailing, and both leading and trailing edges of the axisymmetric cavity. Additionally, detailed experiments are performed to analyze the impact of protrusion lengths on unsteady cavity pressure and far-field noise radiation. Cavity pressure fluctuations and far-field noise levels are measured for both cases: with and without protrusions in the pipe-cavity setup. The Proper Orthogonal Decomposition (POD) technique is applied to the time-resolved Schlieren images to show the effect of passive protrusions on the exit jet flow structure. Results demonstrate that a protrusion located at the trailing edge yields superior noise reduction compared to other configurations. The efficacy of this protrusion in mitigating cavity noise is attributed to its ability to efficiently alleviate the feedback mechanism responsible for cavity noise generation and break down the recirculation region within the cavity system. Significant noise reduction, approximately 4 dB, is achieved at lower NPRs, and substantial noise reductions are also observed for the underexpanded jet condition.
On the relationship between acoustic absorption and temperature gradient in a thermoacoustic liner
Authors: Biswas Samarjith , Kresl William , Manimala James M 
Published: December 2024

The thermoacoustic effect provides a means to convert acoustic energy to heat and vice versa without the need for moving parts. This makes thermoacoustic devices of interest for multifunctional applications in harsh or remote service environments. Embedding thermoacoustic stacks within the framework of acoustic liners could provide opportunities to simultaneously optimize both acoustic absorption and thermal output as well as to integrate energy harvesting and sensing and monitoring functionalities. In this study, the influence of sound pressure level and frequency as well as stack length and position on the performance of a thermoacoustic liner is investigated using normal incidence impedance tube tests and DeltaEC simulations. Using Rott’s approximation, the stack’s pore width and wall thickness are optimized for additively manufactured thermoacoustic liner test articles. A peak steady-state temperature gradient of 9.5°C is obtained at 790 Hz for 140 dB tonal dwells. It is found that the temperature gradient correlates directly with the acoustic power available at the leading stack-face, which is highest when the stack is near the center of the resonator. In contrast, acoustic absorption diminishes when the stack is nearer to the closed-end of the resonator. At higher excitation pressure levels, the contribution of viscous heating to the deviation in the thermoacoustic gradient becomes significant. Further, the relationship between the acoustic absorption and the thermoacoustic temperature gradient was examined. In application scenarios requiring multifunctional optimization, a tradeoff may be required in terms of the absorption in order to maximize the temperature gradient. With current additive and hybrid fabrication processes and materials reaching commercial maturity, opportunities exist to realize thermoacoustic liners with enriched functionalities.
Recanalization of occluded right innominate vein in presence of a persistent LeVeen shunt: A vascular access rescue case
Authors: Menegolo Mirko , Spertino Andrea , Menara Sabrina , Squizzato Francesco , Antonello Michele , Maturi Carlo 
Published: December 2024

Background Superior vena cava syndrome (SVCs) is a common complication in hemodialysis patients due to central vein occlusions, often caused by prior catheterizations. Management can be challenging. Objective To describe a successful endovascular approach to managing SVCs caused by right innominate vein (RIV) occlusion in a hemodialysis patient with a non-functional LeVeen shunt. Method An 80-year-old dialysis patient with upper limb edema and vascular access dysfunction was diagnosed with complete RIV occlusion around a long-standing LeVeen shunt. Recanalization was achieved via a percutaneous approach, including angioplasty and placement of a balloon-expandable covered stent, leaving the LeVeen shunt in situ to reduce risks. Results The procedure restored venous patency and improved vascular access functionality. Postoperative imaging confirmed excellent stent positioning and reduced venous congestion. At a 6-month follow-up, central vein patency was maintained. Conclusion Endovascular recanalization is a safe and effective strategy for managing SVCs, even with a retained central venous device. This approach preserved vascular access and ensured successful long-term dialysis, offering insights for treating complex venous occlusions.
Technical note: Improving orbital atherectomy efficacy for calcified nodules using a curved guide catheter
Authors: Iiya Munehiro , Kobayashi Isshi , Onishi Yuko 
Published: December 2024

Objectives Endovascular therapy (EVT) for calcified nodules in patients with peripheral artery disease (PAD) remains challenging in achieving favorable outcomes. This study aims to investigate the effectiveness of orbital atherectomy (OA) for calcified nodules using an IM catheter to precisely control the device and achieve optimal engagement with the target lesion. Methods We performed EVT for a calcified nodule in the right common femoral artery using an OA. Due to the large vessel size, controlling the OA to effectively engage the lesion was challenging. To overcome this, we utilized an IM catheter to guide the OA toward the target lesion. Results The use of the IM catheter successfully directed the OA to the calcified lesion, resulting in significant lumen enlargement. The procedure was completed without any complications, and the OA achieved effective debulking of the calcified nodule. Conclusions The combination of OA and IM catheter facilitated effective contact with the target lesion, improving the performance of the debulking device. This approach may enhance the management of calcified lesions in large-diameter arteries during EVT, potentially leading to better clinical outcomes.
SCORE2 is superior to SCORE in predicting the presence of carotid plaques and intima-media thickness in rheumatoid arthritis patients: a cross-sectional study using carotid ultrasound
Authors: Campos Fernández Cristina , Fragío Gil Jorge Juan , González Mazarío Roxana , Martínez Calabuig Pablo , Román Ivorra José Andrés 
Published: December 2024

Background: Rheumatoid arthritis (RA) increases the risk of premature mortality, primarily due to cardiovascular diseases (CVD). While Systematic Coronary Risk Evaluation (SCORE) and its updated version SCORE2 are used to estimate CVD risk, these tools may not adequately capture the full cardiovascular risk profile in RA patients. Objectives: This study aims to compare the effectiveness of SCORE2 versus SCORE in predicting the presence of carotid plaques or increased intima-media thickness (IMT), as detected by ultrasound, in RA patients. Design: This was a single-center cross-sectional study and included adult RA patients with moderate to severe disease who initiated treatment with Janus kinase inhibitors or anti-tumor necrosis factor inhibitors between September 2022 and April 2023. Methods: Both SCORE and SCORE2 were calculated for each patient. Carotid ultrasound examinations documented the presence of plaques, and IMT was measured. Results: A total of 122 patients were included. The mean SCORE was 2.48%, while SCORE2 was significantly higher at 4.07% ( p < 0.01). SCORE identified 12 (10%) patients as high risk, while SCORE2 identified 99 (81%). Atherosclerotic plaques were present in 34% ( n = 42) of participants. Traditional cardiovascular risk factors (dyslipidemia, diabetes, hypertension, and smoking) were significantly associated with ultrasound-detected risk. In 87 cases where SCORE was underestimated, 34 patients (39%) classified as low–moderate risk by SCORE were correctly reclassified as high risk by SCORE2. However, 54 cases classified as high risk by SCORE2 had normal carotid ultrasounds. The sensitivity of SCORE for predicting plaque presence was 21%, compared to 100% for SCORE2. Combining SCORE with carotid ultrasound increased the detection of high-risk patients from 10% to 38%. However, adding carotid ultrasound to SCORE2 did not increase the detection rate beyond 81%. Conclusion: Our findings highlight the superior performance of SCORE2 compared to SCORE in identifying RA patients with carotid ultrasound abnormalities, thus indicating a higher cardiovascular risk.
Imperforate nasopharynx in a cat successfully treated with an extended palatoplasty
Authors: Hess Michal O 
Published: December 2024

Case summary A female intact domestic shorthair kitten was evaluated at 8 months of age for bilateral mucopurulent nasal discharge, stertor, open-mouth breathing and difficulty eating. Imperforate nasopharynx (INP) was diagnosed on oronasal examination under anesthesia. An extended palatoplasty was performed and resulted in resolution of the clinical signs. Relevance and novel information The extended palatoplasty procedure is relatively simple and very similar to the correction of soft palate elongation in brachycephalic dogs. It does not require special equipment and materials; therefore, it represents a viable, more readily available and cost-effective option for the treatment of INP. To the author’s knowledge, this is the first case of INP that has been treated with extended palatoplasty.
The role of acupuncture in treating premature ejaculation and its probable neurobiological mechanism
Authors: Wang Anmin , Wang Hao , Ma Dongyue , Chang Hongyuan , Zhao Ziwei , Luo Dicheng , Wang Fu 
Published: December 2024

Abstract
Background
Premature ejaculation (PE) is one of the most common diseases in andrology and leads to serious male sexual dysfunction. Although several targeted oral drug therapies are used to treat PE, they often face challenges related to imprecise targeting and adverse effects. Acupuncture has shown potential in prolonging ejaculation time and improving couples' sexual quality of life. This review aims to summarize the benefits of acupuncture in treating PE and explore its probable neurobiological mechanisms.

Results
The review included eight clinical trials involving 679 patients, of which 294 were treated with acupuncture. Furthermore, this review analyzed acupuncture points, needle retention time, treatment duration, and their probable neurobiological mechanisms. The proposed mechanisms include stimulating the frontal functional lobe, inhibiting spinal cord neural pathways, regulating serotonin levels, enhancing 5-hydroxytryptamine receptor IB excitability, reducing penile sensitivity, and modulating hormone levels.

Conclusions
Acupuncture is a viable alternative or complementary therapy for PE, and neurobiological mechanisms appear to play a key role, but further experimental validation is needed.
Anti-septin complex positive autoimmune encephalitis after severe falciparum malaria: a case report
Authors: Kalbitz Sven , Arlt Friederike A. , Wolf Johannes , Corty Merle , Prüss Harald , Lübbert Christoph 
Published: December 2024

Abstract
Background
Post malaria neurologic syndrome (PMNS) is a rare complication of malaria, usually caused by Plasmodium falciparum. The clinical picture is highly variable and ranges from qualitative disturbances of consciousness and psychosis to damage to the peripheral nerves, usually occurring three to eight weeks after treated malaria.

Case presentation
We report the case of a 54-year-old male who presented with recurrent clinical symptoms three and a half weeks after severe falciparum malaria. After ruling out recurrent malaria, autoimmune encephalitis was suspected. Corticosteroid therapy led to a rapid improvement of the clinical symptoms. The extended examinations (including cranial MRI and FDG-PET/CT) revealed no pathological findings. Routine serologic autoimmune diagnostics remained negative. However, anti-septin complex antibodies were detected in the serum in a cell-based and a tissue-based immunofluorescence assay. Twelve months after discontinuation of corticosteroid therapy, the patient was free of immunosuppressants and completely asymptomatic.

Conclusion
To our knowledge, this is the first case of septin complex autoimmunity with encephalitis associated with PMNS. All physicians treating malaria patients should therefore be aware of this rare condition and consider extended autoimmune diagnostics if routine panels remain unremarkable.
Systematic review of peri-implant conditions and aesthetic outcomes of customized versus conventional healing abutments
Authors: Ruhstorfer Miriam , Güth Jan-Frederik , Stimmelmayr Michael , Waltenberger Lukas , Schubert Oliver , Graf Tobias 
Published: December 2024

Abstract
Purpose
Customized healing abutments are utilized to enhance aesthetics and peri-implant soft and hard tissue health, and play a crucial role in the implant-prosthetic workflow. This systematic review was performed to assess and compare the clinical outcomes of customized healing abutments with conventional ones.

Methods
The review was registered with PROSPERO (ID: CRD42024532449) and followed the PRISMA-guidelines. The PICO-question addressed was: “In patients with dental implants, do customized healing abutments result in beneficial peri-implant conditions compared with conventional healing abutments?” Clinical trials involving immediate and late implant placement that compared different healing abutments based on quantifiable outcomes were included. The “PubMed”, “PubMed Central”, “Cochrane Library”, and “Web of Science databases” were screened for eligible studies until 4/20/2024.

Results
Of 1,396 titles retrieved, 5 studies met the inclusion criteria and were analyzed. The included studies showed a low risk of bias as assessed by the RoB2 tool and Joanna Briggs Institute Critical Assessment questionnaire. Compared to conventional healing abutments, customized abutments were associated with a trend toward better clinical outcomes in peri-implant soft and hard tissue, as well as aesthetics. Several results within the cohorts using customized healing abutments showed significantly improved values in soft and hard tissue results as well as aesthetic parameters. Importantly, none of the included studies reported biological or aesthetic disadvantages associated with the use of customized healing abutments.

Conclusions
Customized healing abutments maintain stability of peri-implant hard and soft tissue. However, further studies with larger sample sizes and longer follow-up periods are needed to validate these findings.

Graphical Abstract