bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal‐type epitheloid sarcoma mimicking a wart in a child: A diagnosis not to be missed
Authors: George Kimberley , Morren Marie‐Anne , Christen Thierry , Letovanec Igor , Christen‐Zaech Stephanie 
Published: November 2020

AbstractEpithelioid sarcoma is a rare soft‐tissue tumor that occurs mainly in children and young adults. It typically presents as a subcutaneous or deep dermal mass in distal extremities. Due to its benign‐appearing clinical presentation, infrequent occurrence, and histologic similarities with other pathologies, the diagnosis of epithelioid sarcoma in its early stages can be extremely difficult and can be easily confused with benign lesions such as warts or foreign body granuloma. In this paper, we report the case of a 12‐year‐old boy with a distal‐type epithelioid sarcoma of the hand and wish to emphasize the difficulties of diagnosing this potentially lethal tumor both clinically and histologically.
Disseminated cutaneous tuberculosis from BCG vaccination site in an immunocompetent child
Authors: Dhar Sandipan , Ganjoo Shikhar , Dhar Subhra , Srinivas Sahana M. 
Published: November 2020

AbstractA healthy 4‐month‐old girl presented with widespread scaly papules and a nodule over the site of BCG immunization. A diagnosis of disseminated cutaneous tuberculosis in an immunocompetent child was confirmed with biopsy. The child was treated with antituberculosis therapy without recurrence.
Dupilumab for pediatric prurigo nodularis: A case report
Authors: Fachler Tahel , Maria Faitataziadou Sofia , Molho‐Pessach Vered 
Published: November 2020

AbstractHerein we report on a 9‐year‐old girl with recalcitrant prurigo nodularis unresponsive to multiple standard treatments. She was started on dupilumab therapy with rapid improvement in pruritus within 2 weeks and near complete regression of lesions at 3 months. Dupilumab should be considered as an off‐label treatment for refractory prurigo nodularis in children.
Acne and social media: A cross‐sectional study of content quality on TikTok
Authors: Zheng David X. , Ning Anne Y. , Levoska Melissa A. , Xiang Laura , Wong Christina , Scott Jeffrey F. 
Published: November 2020

AbstractOur objective was to assess the quality of acne‐related medical information present on TikTok, the world's fastest growing social media platform. We queried the TikTok mobile application for videos tagged with “#acne” on May 1, 2020, and assessed the top 100 videos meeting inclusion criteria for content quality using DISCERN, a validated and reliable instrument for evaluating consumer health information. The mean content quality rating of videos was 2.03 (SD 0.47) which, according to the DISCERN instrument, indicates information with serious to potentially important shortcomings. Dermatologists should be aware that adolescents are using TikTok to gather acne‐related information, and should prioritize acne education in this patient demographic due to the generally low content quality of such information.
The heterologous expression of a plastocyanin in the diatom Phaeodactylum tricornutum improves cell growth under iron‐deficient conditions
Authors: Castell Carmen , Bernal‐Bayard Pilar , Ortega José M. , Roncel Mercedes , Hervás Manuel , Navarro José A. 
Published: November 2020

AbstractWe have investigated if the heterologous expression of a functional green alga plastocyanin in the diatom Phaeodactylum tricornutum can improve photosynthetic activity and cell growth. Previous in vitro assays showed that a single‐mutant of the plastocyanin from the green algae Chlamydomonas reinhardtii is effective in reducing P. tricornutum photosystem I. In this study, in vivo assays with P. tricornutum strains expressing this plastocyanin indicate that even the relatively low intracellular concentrations of holo‐plastocyanin detected (≈4 μM) are enough to promote an increased growth (up to 60%) under iron‐deficient conditions as compared with the WT strain, measured as higher cell densities, content in pigments and active photosystem I, global photosynthetic rates per cell, and even cell volume. In addition, the presence of plastocyanin as an additional photosynthetic electron carrier seems to decrease the over‐reduction of the plastoquinone pool. Consequently, it promotes an improvement in the maximum quantum yield of both photosystem II and I, together with a decrease in the acceptor side photoinhibition of photosystem II—also associated to a reduced oxidative stress—a decrease in the peroxidation of membrane lipids in the choroplast, and a lower degree of limitation on the donor side of photosystem I. Thus the heterologous plastocyanin appears to act as a functional electron carrier, alternative to the native cytochrome c6, under iron‐limiting conditions.
Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective
Authors: Ferreira‐Neto José R. C. , da Silva Manassés D. , Rodrigues Fabiana A. , Nepomuceno Alexandre L. , Pandolfi Valesca , de Lima Morais David A. , Kido Ederson A. , Benko‐Iseppon Ana M. 
Published: November 2020

AbstractThis work presents a robust analysis of the inositols (INSs) and raffinose family oligosaccharides (RFOs) pathways, using genomic and transcriptomic tools in cowpea under root dehydration. Nineteen (~70%) of the 26 scrutinized enzymes presented transcriptional up‐regulation in at least one treatment time. The transcriptional orchestration allowed categorization of the analyzed enzymes as time‐independent (those showing the same regulation throughout the assay) and time‐dependent (those showing different transcriptional regulation over time). It is suggested that up‐regulated time‐independent enzymes (INSs: myo‐inositol oxygenase, inositol‐tetrakisphosphate 1‐kinase 3, phosphatidylinositol 4‐phosphate 5‐kinase 4‐like, 1‐phosphatidylinositol‐3‐phosphate 5‐kinase, phosphoinositide phospholipase C, and non‐specific phospholipase C; RFOs: α‐galactosidase, invertase, and raffinose synthase) actively participate in the reorganization of cowpea molecular physiology under the applied stress. In turn, time‐dependent enzymes, especially those up‐regulated in some of the treatment times (INSs: inositol‐pentakisphosphate 2‐kinase, phosphatidylinositol 4‐kinase, phosphatidylinositol synthase, multiple inositol polyphosphate phosphatase 1, methylmalonate‐semialdehyde dehydrogenase, triosephosphate isomerase, myo‐inositol‐3‐phosphate synthase, phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase and protein‐tyrosine‐phosphatase, and phosphatidylinositol 3‐kinase; RFOs: galactinol synthase) seem to participate in fine‐tuning of the molecular physiology, helping the cowpea plants to acclimatize under dehydration stress. Not all loci encoding the studied enzymes were expressed during the assay; most of the expressed ones exhibited a variable transcriptional profile in the different treatment times. Genes of the INSs and RFOs pathways showed high orthology with analyzed Phaseoleae members, suggesting a relevant role within this legume group. Regarding the promoter regions of INSs and RFOs genes, some bona fide cis‐regulatory elements were identified in association with seven transcription factor families (AP2‐EFR, Dof‐type, MADS‐box, bZIP, CPP, ZF‐HD, and GATA‐type). Members of INSs and RFOs pathways potentially participate in other processes regulated by these proteins in cowpea.
As Births Diminish and Deaths Increase, Natural Decrease becomes More Widespread in Rural America*
Authors: Johnson Kenneth M. 
Published: November 2020

AbstractEven before the onset of the Covid‐19 pandemic, the U.S. population growth rate last year was the lowest in 100 years. And, from 2010 to 2019 nonmetropolitan America lost population for the first time in history. Diminished natural increase was a major contributor to this and also accelerated the incidence of natural decrease (more deaths than births), particularly in rural America. Deaths exceeded births in 46 percent of all U.S. counties—a near record high. Nearly 79 percent of these natural decrease counties were nonmetropolitan. This research uses recent data and a multivariate spatial regression model to update our understanding of the growing incidence of natural decrease in both rural and urban America. In light of the mortality increase and likely fertility declines stemming from the Covid‐19 pandemic, these findings have significant implications for future nonmetropolitan demographic trends.
A review on the interactions between dendritic cells, filarial parasite and parasite‐derived molecules in regulating the host immune responses
Authors: Joardar Nikhilesh , Mondal Chandrani , Sinha Babu Santi P. 
Published: November 2020

AbstractLymphatic filariasis (LF) is the second leading cause of parasitic disabilities that affects millions of people in India and several other tropical countries. The complexity of this disease is endorsed by various immunopathological consequences such as lymphangitis, lymphadenitis and elephantiasis. The immune evasion strategies that a filarial parasite usually follows are chiefly initiated with the communication between the invaded parasites and parasite‐derived molecules, with the Toll‐like receptors (TLRs) present on the surface of the antigen‐presenting cells (APCs). Classically, the filarial parasites interact with the DCs resulting in lowering of CD4+ T‐cell responses. These CD4+ T‐cell responses are the key players behind the immune‐mediated pathologies associated with LF. In chronic stage, the canonical pro‐inflammatory immune responses are shifted towards an anti‐inflammatory subtype, which is favouring the parasite survivability within the host. The central theme of this review article is to present the overall immune response elicited when an APC, particularly a DC, encounters a filarial parasite.
Establishing best practices in measles, mumps, and rubella serologic screening for kidney transplant candidates
Authors: Ramakrishna Jahanavi M. , Brumble Lisa M. , Larimore Kelly L. , Wadei Hani M. , Jarmi Tambi , Libertin Claudia R. 
Published: November 2020

AbstractOptimizing immunity against vaccine‐preventable diseases improves outcomes in kidney transplant (KT) patients (Arora et al,World J Transplant, 2019, 9:1; Sester et al,Transplant Rev, 2008, 22:274; Fishman,N Engl J Med, 2007, 357:2601). The American Society for Transplantation (AST) Clinical Practice Guidelines advises that serologic screening for measles, mumps, and rubella (MMR) be conducted for all KT candidates, since live‐attenuated vaccines are contraindicated post‐transplantation (Malinis et al,Clin Transplant, 2019, 33:e13548). Our team at Mayo Clinic Florida (MCF) conducted a quality improvement (QI) initiative to establish a best MMR screening and immunizations clinical practice in KT candidates using a Plan‐Do‐Study‐Act (PDSA) model. By retrospective chart review of all KT candidates evaluated at our institution from January 1, 2016 to December 31, 2017, baseline data determining the rate of MMR serologic screening was established. PDSA cycles were implemented to adopt protocol‐driven testing for MMR serologies, immunization documentation, and vaccination in cases of seronegativity to any of the three MMR viruses in all pre‐KT candidates. Two PDSA cycles were completed in 4 months. The study population totaled 447 patients (baseline n = 283, PDSA 1 n = 61, PDSA 2 n = 103). Baseline data showed that 83% (n = 235) of pre‐KT candidates received infectious disease consultation (IDC). Complete MMR (all three viruses) serological screening in KT candidates improved from baseline 3.9%‐87.4% post‐PDSA cycle 2 (P < .001). Necessary immunizations per AST guidelines were ordered in only 41.1% (n = 23) of the control cohort vs 100% (n = 12) and 96.9% (n = 31) of PDSA cycles 1 and 2, respectively (P < .001). The data reflect significant practice improvements in MMR screening and immunization rates among KT candidates by using protocol‐driven orders combined with our pre‐existing IDCs.
The effect of cannabidiol on canine neoplastic cell proliferation and mitogen‐activated protein kinase activation during autophagy and apoptosis
Authors: Henry Joshua G. , Shoemaker Gregory , Prieto Jennifer M. , Hannon Many Beth , Wakshlag Joseph J. 
Published: November 2020

AbstractLow tetrahydrocannabinol Cannabis sativa products, also known as hemp products, have become widely available and their use in veterinary patients has become increasingly popular. Despite prevalence of use, the veterinary literature is lacking and evidence‐based resource for cannabinoid efficacy. The most prevailing cannabinoid found in hemp is cannabidiolic acid (CBDA) and becomes cannabidiol (CBD) during heat extraction; CBD has been studied for its direct anti‐neoplastic properties alone and in combination with standard cancer therapies, yielding encouraging results. The objectives of our study were to explore the anti‐proliferative and cell death response associated with in vitro treatment of canine cancer cell lines with CBD alone and combination with common chemotherapeutics, as well as investigation into major proliferative pathways (eg, p38, JNK, AKT and mTOR) potentially involved in the response to treatment with CBD. CBD significantly reduced canine cancer cell proliferation far better than CBDA across five canine neoplastic cell lines when treated with concentrations ranging from 2.5 to 10 μg/mL. Combinatory treatment with CBD and vincristine reduced cell proliferation in a synergistic or additive manner at anti‐proliferative concentrations with less clear results using doxorubicin in combination with CBD. The cellular signalling effects of CBD treatment, showed that autophagy supervened induction of apoptosis and may be related to prompt induction of ERK and JNK phosphorylation prior to autophagy. In conclusion, CBD is effective at hindering cell proliferation and induction of autophagy and apoptosis rapidly across neoplastic cell lines and further clinical trials are needed to understand its efficacy and interactions with traditional chemotherapy.
Effectiveness of Multidisciplinary Care for Chronic Kidney Disease: A Systematic Review
Authors: Hsu Hsin‐Tien , Chiang Yen‐Chiu , Lai Yu‐Hung , Lin Li‐Yuan , Hsieh Hsiu‐Fen , Chen Jyu‐Lin 
Published: November 2020

AbstractBackgroundChronic kidney disease (CKD) is a common chronic disease. As this disease is extremely complex, multidisciplinary care (MDC) is needed to provide complete and continuous care.AimA systematic literature review was performed to examine the constituents of MDC, the content of MDC interventions, and the health outcomes in CKD patients receiving MDC.MethodsSearches of five Chinese and English databases for studies of CKD patients who had received MDC from 2007 to 2019 revealed 11 studies, which comprised 16,066 CKD patients. The Physiotherapy Evidence Database scale (Physiotherapy Evidence Database, 2017) was used to appraise study quality for randomized controlled trials, and the Joanna Briggs Institute Critical Appraisal tools (Joanna Briggs Institute, 2017) were for cohort studies.ResultsThe MDC teams that provided comprehensive medical care for these patients included nephrologists, nurses, surgeons, general practitioners, pharmacists, psychotherapists, social workers, nutritionists, and other specialists. The literature review revealed that MDC for CKD slows the decline in estimated glomerular filtration rate and decreases patient mortality, the risk of renal replacement therapy, the need for emergent dialysis, and annual medical costs. Analyses of biochemical markers in the CKD patients showed that MDC improves control of serum levels of calcium and phosphate, improves control of parathyroid hormone, and reduces proteinuria and fasting blood glucose values. However, further studies are needed to determine the effects of MDC on all‐cause mortality, blood pressure control, hospitalization rate, hospitalization for cardiovascular or infection events, medications use, and other biochemical markers in CKD patients.Linking Evidence to ActionCross‐disciplinary collaboration of healthcare professionals is needed to ensure that patients undergo regular follow‐up and periodic assessment of clinical status, in addition to ensuring that relevant resources and assistance are provided in a timely manner. A follow‐up period of at least 2 years is also needed to ensure sufficient time to observe MDC results.
Technical Basis for Proposed Revisions to ASME Section III Code Case N-891 on Maximum Allowable Indentation Depths in HDPE Pipe to Extend Applicability to PENT Ratings Up to 10,000 Hours
Authors: Scarth Douglas , Krishnaswamy Prabhat , Rush Phillip , Munson Douglas 
Published: December 2020

Abstract
Mandatory Appendix XXVI of Section III of the ASME B&PV Code contains rules for the construction of Class 3 pressure piping systems comprised of PE4710 High Density Polyethylene (HDPE) with a minimum Pennsylvania Notched Test (PENT) rating of 2,000 hours. Appendix XXVI contains acceptance standards for the maximum allowable depths of gouges, cuts or other surface conditions that are characterized as indentations. The acceptance standards are very conservative, in particular for large diameter HDPE pipes. Less restrictive maximum allowable indentation depths for PE4710 HDPE pipes with a minimum PENT rating of 2,000 hours were previously developed based on analyses of tests on HDPE pipes containing scratches. These less restrictive maximum allowable indentation depths were published in the ASME Section III Code Case N-891 as an alternative to the acceptance standards in Appendix XXVI. The PENT rating of PE4710 HDPE material can significantly exceed 2,000 hours, and the current maximum allowable indentation depths in Code Case N-891 are overly-restrictive for the higher PENT ratings. Maximum allowable indentation depths for PENT ratings up to 10,000 hours have been developed, and are proposed to be implemented into a revision of Code Case N-891 and Appendix XXVI. The technical basis for the maximum allowable indentation depths for these higher PENT ratings is provided in this paper. The proposed revisions to Code Case N-891 include a provision to permit use of results from accelerated PENT testing at a higher temperature and stress level than standard PENT test conditions. The technical basis for the use of results from accelerated PENT testing is also provided in this paper.
Mean Stress Correction of S45C Carbon Steel Based on Crack Growth Concept
Authors: Kamaya Masayuki 
Published: December 2020

Abstract
Influence of the mean stress on fatigue life and fatigue limit was investigated for carbon steel. Uni-axial fatigue tests were conducted under stress and strain-controlled conditions at room temperature. The fatigue life and fatigue limit were reduced by applying the mean stress for the same stress amplitude. The fatigue life exhibited a better correlation with the strain range than the stress amplitude did. Increase in strain range caused by applying the mean stress correlated well with the decrease in the fatigue life. It was assumed that the mean stress effect on the fatigue life was brought about by the change in crack growth rate caused by applying the mean stress. The mean stress enhanced crack mouth opening and accelerated the crack growth. The reduction in the fatigue limit was also brought about by the same effect. It was shown that the effective strain range gave good prediction of fatigue life and fatigue limit with and without the mean stress.
Creating Thirdspace Physical Culture for, With, and About Recent Immigrant Girls: Instagram as a Space of Marginalization and Resistance
Authors: Lee Jihyeon , Azzarito Laura 
Published: November 2020

Recent reports have indicated that recent immigrant minority girls are the least physically active in the United States and are often categorized as “bodies-at-risk” for obesity and other health issues. This dominant “at-risk” discourse presents a negative image of recent immigrant minority girls and positions them as “others.” This participatory visual study thus explored how the recent immigrant minority girls co-constructed and shared their (dis)engagement in physical culture on a popular social media platform: Instagram. Results demonstrated that the use of Instagram served two interrelated functions: (a) a constructive pedagogical space in which the participants examined, learned, and expressed their knowledge related to physical activity and health and (b) an empowering tool to create “Thirdspace” in which the participants’ visual texts opened up the space of inclusion and fluidity. Despite potential risks, it was suggested that the use of Instagram was beneficial for conducting research with, for, and about marginalized youth.
A construction of timelike ruled surfaces in Minkowski three-space 𝔼13
Authors: Alluhaibi Nadia , Mofarreh Fatemah 
Published: November 2020

In this work, by using the E. Study map, we construct timelike ruled surfaces with constant Disteli-axis based upon the curvature theory of dual hyperbolic (respectively, Lorentzian) spherical curves which match to timelike ruled surfaces in Minkowski 3-space [Formula: see text]. Meanwhile, some well-known formulae of surfaces theory into line space and their geometrical explanations are investigated.
Merleau-Ponty on the Sexed Body
Authors: Rae Gavin 
Published: November 2020

Abstract
This paper engages with Maurice Merleau-Ponty’s account of the sexed body in the Phenomenology of Perception. I focus on his notion of the sexual schema to show that, contrary to a number of feminist critiques, it does not (1) posit a neutral body overcoded by culturally-contingent sexual determinations or (2) erase the feminine body, but is informed by Merleau-Ponty particular version of the phenomenological reduction whereby factic determinations are “bracketed” to permit the object under study to reveal itself as it is rather than as we wish it to be or have been conditioned to think it. I subsequently defend Merleau-Ponty against the long-standing claim that entwining sexuality with existence prevents an analytic and by extension positive conception of sexuality by arguing that he rejects the monadic logic that this charge is premised on to instead challenge us to think of sexuality in terms of its integration with an individual’s entire embodied, embedded existence. The result is an analysis that emphasizes the ambiguity, afoundationalism, individuality, and open-ended immanent expressivity of sexuality.
Richard Kearney’s Relevance for Psychology: A Review Essay
Authors: DeRoo Neal 
Published: November 2020

Abstract
This essay argues that Richard Kearney’s philosophical work has something important to say to phenomenological psychology and, in turn, has something important to learn from it. It begins by highlighting a movement of return after deconstruction, consistent throughout Kearney’s oeuvre, that emerges clearly in the recently published Imagination Now collection—which contains some of Kearney’s most important writings. It then shows how this movement is a fundamentally therapeutic endeavor. A quick review of several recent volumes about Kearney’s work makes clear how his philosophy suggests an embodied and not simply a linguistic approach to therapy. As such, a certain phenomenological psychology is revealed as being implicitly operative in Kearney’s work. The essay then ends by highlighting three possible benefits of having phenomenological psychologists engage with Kearney’s work: a revaluation of the non-cognitive aspects of subjective constitution, a renewed look at the role of both the narrative and carnal dimensions in psychological research and psychotherapy, and an even more enhanced socio-cultural role for phenomenological psychology.