bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability of an additive-quadratic-quartic functional equation
Authors: Kim Gwang Hui , Lee Yang-Hi 
Published: February 2020

AbstractIn this paper, we investigate the stability of an additive-quadratic-quartic functional equation$$\begin{align*}f(x+2y)& +f(x-2y)-2f(x+y)-2f(-x- y)-2f(x-y)-2f(y-x)\nonumber \\ &+4f(-x)+ 2f(x)-f(2y)-f(-2y)+4f(y)+4f(-y)=0 \end{align*}$$by the direct method in the sense of Găvruta.
Records and Transformations of Memories in the Cultural Landscape of Idomeni (Kilkis, Northern Greece)
Authors: Chatzitoulousis Stamatis , Vlasidis Vlasis , Sarris Apostolos , Efkleidou Kalliopi , Kotjabopoulou Eleni , Papadopoulos Nikos , Argyriou Nasos , Donati Jamie , Manataki Meropi , Trapero-Fernandez Pedro 
Published: February 2020

AbstractFollowing recent excavations and geophysical prospection at Idomeni in the Kilkis prefecture of Northern Greece, this paper attempts to reconstruct through digital means, the tangible and intangible vestiges of historical episodes that come together to form multiple narratives of a diachronically terra incognita site, gradually unlocking its hidden secrets. The digital documentation and processing, with the use of Geographical Information Systems (GIS), of the spatial remains associated with historical episodes demonstrate the ways in which space at Idomeni was used within a multifaceted, diachronic framework. It is a place that is constantly being transformed over the past 7000 years from a seemingly “peaceful” agricultural community during the Neolithic period to a burial ground for a still invisible Middle Byzantine settlement, and finally, as a place of violence having been one of the battlefields of the First World War. The story of Idomeni has only recently been concluded as the theatre of a dramatic influx of modern refugees. Thus, the “multilayered” identity of a mnemonic place with various representations of the past unfolds: on one hand the distant eras, such as the still unknown Neolithic and Middle Byzantine period, and on the other, the relatively recent “traumatic” (war-related) past. Within the specific historical context of the First World War, this paper discusses the management of memories of locals and non-locals, e.g. the disappearance of entire settlements, or the emergence of new toponyms related to the protagonists and their actions during the war in the area of Idomeni remaining in the memory of locals today.
Synergy and optimization of Local institutional to Repair Gambir (Uncaria gambir Roxb) Market in Indonesia
Authors: Wedy Nasrul  , Zulmardi  , Indrayani Tri Irfa 
Published: February 2020

The relation between institutions and synergy between social capital produce social capital performance. Relationship and synergy between social capital between institutions will produce the best collective action. Collective action formed able to solve a problem in and between the institutions. Research aim of looking at the a lot of synergy of local institutions, the performance of social capital are quoted on the gambir. So on as well will be canvassed to see the act of collectively that is formed to address the issues the market gambir.This research methodology used a quantitative approach. The kind of research is descriptive. This study using a case study in the agricultural gambir. Research methodology this used a quantitative approach.The kind of research is descriptive. The research uses strategy case study. A case study of agricultural market gambir (Uncaria Gambir Roxb). Enrichment data used method of qualitative. Forms used as, observation, interview, group discussions and documentation. Data analysis in depth uses the method inductive analysis and logical analysis. The analysis of the performance of social capital market gambir shows high social capital performance. High social capital performance on the gambir because the network high on bonding social capital and sinerji high on bridging social capital. High social capital performance produce collective action. Collective action happened transact on time and the same place between farmers and gambir gatherers in the market village. The transaction in time and place the same caused the price of more competitive because the competition among gambir gatherers. Social capital has also built the collective action for the repair of products and the sustainability of gambir farming.
ALTERAÇÕES NA TEMPERATURA DA SUPERFÍCIE DO SOLO EM FUNÇÃO DO USO E OCUPAÇAO EM ÁREAS VERDES URBANAS
Authors: Lucon Filipe , Longo Regina 
Published: February 2020

Entre os maiores desafios deste século, destaca-se a superação do conflito entre o desenvolvimento e a preservação do meio ambiente. Dentro de centros urbanos, na maioria das cidades brasileiras, não contaram com um planejamento adequado que conciliasse as novas demandas construtivas com a manutenção das áreas verdes, ocasionando a redução excessiva destes ambientes. Em estudos, foi encontrado que, campi universitários são excelentes locais para estudos do clima por apresentar uma estrutura reduzida de uma cidade, o que facilita a tomada de decisões. Tem-se como objetivo avaliar as alterações no clima promovidas em diferentes formas de uso e ocupação do solo, destacando a necessidade de áreas verdes em ambientes urbanos. Por este motivo, foi avaliado a borda de um fragmento florestal, uma trilha, um canavial e uma área urbanizada no entorno de uma universidade.Para este trabalho, foram adotados quatro ambientes que foram estudados no decorrer do mês de maio de 2018. Através do auxílio de instrumento de medição direta, foi determinado a temperatura da superfície do solo nestes quatro ambientes, que foram a borda de um fragmento florestal, uma trilha, um canavial e área urbanizada. Em cada um destes ambientes foi pré-determinado dez pontos de amostragem que foram coletados em três dias diferentes em 3 semanas distintas do mês de maio de 2018 em diferentes horários que foram pré-determinados (9 horas, 15 horas e 18 horas).Para a análise dos dados coletados foi considerado a variação da temperatura do solo em diferentes pontos distribuídos em cada área estudada, bem como a média de cada dia nos diferentes horários e, por fim, foi realizada uma análise da média geral dos ambientes estudados. Foi feito também uma tabela para cada ambiente que expõe dados como a temperatura máxima, temperatura mínima, amplitude térmica e a mediana apresentada nos pontos de amostragem em cada dia e em cada horário pré-determinado.
Arthroscopic Management of Anterior Glenoid Bone Loss
Authors: Lemmex Devin , Cárdenas Gabriel , Ricks Matthew , Woodmass Jarret , Chelli Mikaël , Boileau Pascal 
Published: February 2020

» Anterior glenohumeral instability is a complex problem that requires careful attention to osseous and soft-tissue lesions in order to treat it effectively.» The arthroscopic soft-tissue Bankart repair is considered first-line treatment for patients with anterior glenohumeral instability. However, recent long-term outcome studies have shown surprisingly high failure rates, specifically in the setting of anterior glenoid bone loss.» The definition of “critical” glenoid bone loss that cannot be overcome by a soft-tissue procedure alone continues to evolve and may in fact be lower than the previously published total of 20%.» Arthroscopic reconstruction of the anterior glenoid margin can be performed with either autograft or allograft. The arthroscopic Latarjet procedure has emerged as a reliable and effective technique for autograft augmentation, while the distal aspect of the tibia appears to be a promising source of allograft.
Prenatal diagnosis and pregnancy determination of sex chromosome aneuploidy screened by non-invasive prenatal testing from 52,453 unselected singleton pregnancies: a retrospective analysis of 4-year experience
Authors: Luo Xiaojin , Hu Liang , Pei Yuanyuan , Cong Xiaoyi , Liu Xiaoyi , Chen Jing , Li Gaochi , Wen Lijuan , Liu Jinxing , Ran Jian , Wei Fengxiang 
Published: February 2020

Abstract
Objective To estimate the positive predictive value (PPV) of fetal sex chromosome aneuploidy (SCA) screened in non-selective population and explore the rate of pregnancy termination and ultrasound findings for fetal SCA and the factors influencing parents’ decisions in South China. Methods This is a large-scale retrospective cohort of positive SCA screened from unselected singleton pregnancies by non-invasive prenatal testing (NIPT) from a single prenatal center of a tertiary hospital, from January 2016 to November 2019. Clinical information, indications, diagnostic results, ultrasound findings, pregnancy determinations, and follow-up were reviewed and analyzed. Results 248 cases of SCA positive were screened out of 52453, giving a positive detection rate of 0.47%. The majority of indications (42.7%) were low-risk pregnancies. After genetic counseling, 43 pregnancies (17.3%) declined to prenatal diagnosis, the rest of 205 cases (82.7%) conducted with amniocentesis to detect fetal chromosome, of which 95 were confirmed as true positive of SCA with PPV of 46.3% (95/205). The SCA consisted of 68 sex chromosomal trisomies (26 cases of 47,XXY, 20 cases of 47,XXX and 22 cases of 47,XYY), 17 cases of monosomy X (45,X), three cases of 48,XXYY, three cases of mosaicisms (45,X/46,XX), four cases with sex chromosomal deletions, included two cases of 46,X,del(Y)(q11.21), one case of 46,X,del(X)(p11) and one case of 46,X,i(X)(q10). Of the 95 cases confirmed as true positive SCA, 50 cases (52.6%)chose to terminate the pregnancy (82.6%, 64.3%, 17.6% and 33.3% for 45,X, 47,XXY, 47,XXX and 47,XYY, respectively), 45 cases (47.4%) elected to continue the pregnancy. Ninety-three pregnant were also continued pregnancy after the exclusion of SCA. Conclusions NIPT, as a first-tier routine method for screening autosomal aneuploidies, also could play an important role in screening SCA. Low-risk pregnant women are the main indication for the detection of SCA as NIPT test provides to non-selective population. The trend of overall termination rates of SCA-affected pregnancies is decreased. For 47,XXX and 47,XYY with mild phenotype, couples would like to continue the pregnancy. But for 45,X and 47,XXY, parents apt to terminate pregnancy no matter ultrasound abnormalities were found or not. pregnancy determinations are affected by types of SCA, sonographic findings, maternal age, and presence of infertility.
Vesicle transport in plants: A revised phylogeny of SNARE proteins
Authors: Lindsey Keith , Gu Xiaoyan , Brennan Adrian , Wei Wenbin , Guo Guangqin 
Published: February 2020

Abstract
Background Communication systems within and between plant cells involve the transfer of ions and molecules between compartments, and are essential for development and responses to biotic and abiotic stresses. This is turn requires the regulated movement and fusion of membrane systems with their associated cargo. Recent advances in genomics has provided new resources with which to investigate the evolutionary relationships between membrane proteins across plant species. Results Members of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are known to play important roles in vesicle trafficking across plant, animal and microbial species. Using recent public expression and transcriptomic data from nine representative green plants, we investigated the evolution of the SNARE classes and linked protein changes to functional specialization (expression patterns). We identified an additional three putative SNARE genes in the model plant Arabidopsis. We found that all SNARE classes have expanded in number to a greater or lesser degree alongside the evolution of multicellularity. Sub-functionalization of SNARE family members to different tissues, associated with an accumulation of protein changes is typical, although at least one example of neo-functionalization between the R-SNAREs VAMP722 and VAMP723 was also observed. Conclusion These results provide an insight into SNARE protein evolution and functional specialization. The work provides a platform for hypothesis-building and future research into the precise functions of these proteins in plant development and responses to the environment.
Evaluation of Anti Hyperuricemic Activity of Vitamin E on Potassim Oxonate Induced Hyperuricemic Rat Model
Authors: Sapkota Hariprasad , Sharma Hemraj , Shrestha Shakti , Shrestha Sandhya , Adhikari sudipa , Adhikari Sumana 
Published: February 2020

Abstract
Background Hyperuricemia is often associated with oxidative stress and vitamin E alters uric acid level in hypertensive rats, consequently, vitamin E may have a significant role in non-hypertensive hyperuricemia. Therefore, we aimed to evaluate anti-hyperuricemic activity of vitamin E on potassium oxonate-induced hyperuricemic rats. Methods Eighteen adult Wistar Albino rats of similar weights were equally divided into group I (normal control), group II (disease control) and group III (treatment control). Group I received 0.5ml normal saline per oral while group II and group III received potassium oxonate (250 mg/kg-intraperitoneal) on day 1, 3, 6, 10, 13 and 15. Group III also received vitamin E (200 mg/kg-per oral) for 15 days. Blood samples were collected through retro orbital plexus from all the animals on day 15 to evaluate uric acid, creatinine, total cholesterol, triglycerides, albumin and blood urea nitrogen, as well joint diameter, and kidneys’ weight was also evaluated. Result We observed a statistically significant rise (p<0.05 or p<0.001) in all the parameters and a significant decline in serum albumin level (p<0.001) in group II as compared to group I, but no significant difference (p>0.05) in all the parameters between group I and III. In contrast to this, a significant reduction in all the parameters (p<0.05 or p<0.001) and significant increase in serum albumin level (p<0.001) were observed in group III as compared to group II. Conclusion Our findings suggest that vitamin E has an anti-hyperuricemic activity against hyperuricemia induced rats.
Biological Evaluation and Molecular Modeling of 3,4-dihydropyrimidine- 2(1H)-one Derivatives as Cytotoxic Agents on Breast Cancer In Vitro
Authors: Sharifi Hoda , Ebadi Ahmad , Soleimani Meysam 
Published: February 2020

Background:
Kinesins and tubulin inhibitors have attracted researchers’ attention as
hopeful targets for achieving effective anticancer agents. Dihydropyrimidine-2-ones (DHPMs)
inhibit motor proteins Eg5 in the polymerization process of tubulin, also scaffold bearing
benzothiazole heterocycle can block tubulin polymerization/depolymerization.

Objective:
In this study, the cytotoxic effects and molecular modeling of newly synthesized
derivatives of DHPM that were designed by the Scaffold-hopping approach were investigated as
potential dual-inhibitors of Eg5 and tubulin.

Methods:
We investigated the cytotoxic effects of DHPMs derivatives by MTT assay and measureing
the Caspase 3 activity. Also, molecular modeling studies were performed by AutoDock4 and
GROMACS 4.5.6.

Results:
According to the results, the d2 derivative (IC50 = 68.58 ± 7, SI = 2.57) eliminates MDA-MB-
231 cells in a dose-dependent manner through caspase-dependent and caspase-independent cell death
pathways. Molecular docking studies revealed that the d2 compound could interact with both Eg5 and
tubulin key residues. MD simulation also demonstrated the stability of the studied ligand-receptor
complexes during the 30 ns of the production run. The effectiveness of substitutions at C4 of the
DHPM ring was obtained 4-acetoxy-phenyl, 4-methoxyphenyl, and 4-nitrophenyl, respectively.

Conclusion:
The findings of the present study provide evidence that DHPM C5 amide derivatives
bearing benzothiazole ring might be considered as promising lead compounds for the discovery of
novel and multi-target antitumor agents.
A Vision on Extensions of Canonical Correlation Analysis for Data Interpretation Applications in Compatible Semantic Communication
Authors: Sharma Sandeep , Verma Himani 
Published: February 2020

Background:
A comprehensive approach to Canonical Correlation Analysis (CCA)
technique that explicitly enhances data interpretation by encountering semantic barriers in communication
is proposed.

Object:
To the extent that there exist potential inconsistencies due to redundancy and misinterpretation
of data attributes, compatibility with respect to data interpretation may defer. For a consolidated
and technology dependent network infrastructure, the concept of inclusive CCA (such as
linear CCA, sparse CCA and kernel CCA) further asserts the inclusion of statistical correlational
analysis in semantic communication.

Methods:
A Singular Value Decomposition (SVD) based Latent Semantic Indexing (LSI) method
is substantiated upon a linear dataset and simulation results are canonically analyzed for the same.

Results:
Favorably, the p-value analysis from the t-test validates the significance of the application
of extensions of CCA in the field of semantic communication.

Conclusion:
Hence, CCA as a statistical technique incorporates both symmetric as well as asymmetric
multivariate data analysis to help delineate the incompatibility caused due to subtle semantic-
defects.
The Mediator Roles of Problematic Internet Use and Perceived Stress Between Health Behaviors and Work-Life Balance Among Internet Users in Germany and China: Web-Based Cross-Sectional Study
Authors: Gao Lingling , Gan Yiqun , Whittal Amanda , Yan Song , Lippke Sonia 
Published: February 2020

Background
Work-life balance is associated with health behaviors. In the face of digitalization, understanding this link requires a theory-based investigation of problematic internet use and perceived stress, which are so far unknown.

Objective
On the basis of the compensatory carry-over action model, this study aimed to determine whether problematic internet use and perceived stress mediate the relationship between health behaviors and work-life balance in two groups of internet users from different environments (residents in Germany and China). We also investigated whether the place of residence was a moderator.

Methods
An online questionnaire (N=877) was administered to residents from Germany (n=374) and China (n=503) in 3 languages (German, English, and Chinese). Moderated mediation analyses were run with health behaviors as the independent variable, work-life balance as the dependent variable, problematic internet use and perceived stress as the mediator variables, and place of residence as a potential moderator.

Results
On a mean level, individuals in Germany reported less problematic internet use and more health behaviors than individuals in China; however, they also had lower work-life balance and higher perceived stress. Results showed that health behaviors seem to be directly related to work-life balance in both groups. Among the residents of Germany, a partial mediation was revealed (β=.13; P=.01), whereas among the residents of China, a full mediation was found (β=.02; P=.61). The mediator role of perceived stress was compared with problematic internet use in all the serial models and the parallel model. Residence moderated the relationship between health behaviors and work-life balance: The interrelation between health behaviors and work-life balance was stronger in Germany (β=.19; P<.001) than in China (β=.11; P=.01) when controlling for other variables.

Conclusions
The findings of this study are in line with the compensatory carry-over action model. To promote work-life balance, individuals should perform health behaviors to help overcome problematic internet use and perceived stress. Both problematic internet use and perceived stress mediated health behaviors and work-life balance partially in German study participants and fully in Chinese study participants.
ROBOT PEMBERSIH LANTAI BERBASIS ARDUINO UNO DENGAN SENSOR ULTRASONIK
Authors: Yuliza Yuliza , Kholifah Umi Nur 
Published: February 2020

Perkembangan Ilmu pengetahuan dan teknologi saat ini sangatlah pesat, terutama di bidang teknologi elektronika mempengaruhi kehidupan masyarakat untuk melangkah lebih maju, praktis dan simple. Pada prinsipnya tujuan penciptaan robot adalah untuk mempermudah pekerjaan manusia, apalagi kemajuan zaman menuntut pekerjaan manusia yang efektif dan efisien. Dalam urusan membersihkan rumah terkadang seseorang terlalu mengabaikan karena lelah bekerja.Untuk itu dibuatlah robot/alat pembersih lantai otomatis agar memudahkan ibu rumah tangga dalam membersihkan lantai. Robot pembersih ini bergerak secara otomatis dengan arduino sebagai otak robot. Robot ini bergerak maju sampai bertemu halangan berupa tembokmaka robot/ alat ini akan berbelok ke kiri otomasis sebesar 90 derajat untuk menghindari halangan dan terus membersihkan lantai yang belum di bersihkan, sehingga robot ini sangat cocok digunakan untuk para ibu rumah tangga yang tidak mempunyai waktu untuk membersihkan rumah.Dari hasil pengujian yang telah dilakukan bahwa robot pembersih ini dapat bekerja dengan baik. Bergerak maju mengunakan motor DC dan mengepel lantai menggunakan sikat yang dikendalikan oleh motor DC. Sensor Ultrasonik yang terpasang pada depan robot berfungsi sebagai penentu jarak. Robot ini dapat mempermudah pekerjaan ibu rumah tangga.Kata kunci : Robot pembersih lantai otomatis, Mikrokontroller, Sensor Ultrasonik
INVESTIGATION OF STAIR FLIGHT OVERCOMING BY JUMPING ROBOT
Authors: Vorochaeva Lyudmila , Savin Sergey , Mal'chikov Andrey 
Published: February 2020

In the paper there is considered a stair flight overcoming by a wheel jumping robot during lifting upon it. The robot consists of a casing, an accelerating module ensuring device separation from a surface and a wheel platform at the expense of which a robot moves on even surfaces and it is positioned in front of a stair flight. The latter is characterized with the footstep number, a length and a height of each footstep that defines the number of robot jumps (from one up to footstep number), and also a height and a length of each jump.
In the work there are introduced and described basic parameters of a stair flight, jump characteristics and also the limitations imposed upon a rate of robot separation from a surface and an angle of a slope of its vector and specified by staircase parameters. As qualitative criteria of the stair flight overcoming are energy and time spent at that. As a result of the computational modeling it is determined that at stair flight jumping over in a single bound the required rate of separation of the jumping robot from a surface and also energy and time spent for a jump increase with the growth of the staircase number in the stair flight at that a rate and time – according to curvilinear laws, and energy – proportionally to the number of staircases in the stair flight. Besides, there are investigated six versions for jumping robot to overcome stair flights with the different number of staircases, at that the number of staircases to jump over in a single bound at each version of jump series fulfillment is equal. At that there is no clear regularity between energy and the number of jumps carried out (and staircases to jump over) and time spent increases with the increase of the jump number. The optimization of jumping robot motion on a stair flight from the point of view of the minimization of time and energy consumption is carried out as a result of which the necessity to overcome a staircase in one bound irrespective of the number of footsteps is carried out.