Impact of Coronary Lesion Stability on the Benefit of Emergent Percutaneous Coronary Intervention After Sudden Cardiac Arrest
Authors: Pechmajou Louis , Marijon Eloi , Varenne Olivier , Dumas Florence , Beganton Frankie , Jost Daniel , Lamhaut Lionel , Lecarpentier Eric , Loeb Thomas , Agostinucci Jean-Marc , Sideris Georgios , Riant Elisabeth , Baudinaud Pierre , Hagege Albert , Bougouin Wulfran , Spaulding Christian , Cariou Alain , Jouven Xavier , Karam Nicole , Adnet F , Algalarrondo V , Alla F , Alonso C , Amara W , Annane D , Antoine C , Aubry P , Azoulay E , Benhamou D , Billon C , Boutet J , Bruel C , Bruneval P , Carli P , Casalino E , Cerf C , Chaib A , Cholley B , Cohen Y , Combes A , Coulaud JM , Crahes M , Da Silva D , Das V , Demoule A , Denjoy I , Derkenne C , Deye N , Dhonneur G , Diehl JL , Dinanian S , Domanski L , Dreyfuss D , Duboc D , Dubois-Rande JL , Empana JP , Extramiana F , Fartoukh M , Fieux F , Frattini B , Gabbas M , Gandjbakhch E , Geri G , Guidet B , Halimi F , Henry P , Hidden-Lucet F , Jabre P , Jacob L , Joseph L , Journois D , Lacotte J , Lahlou-Laforet K , Lanceleur A , Langeron O , Lavergne T , Leenhardt A , Lellouche N , Lemiale V , Lemoine F , Linval F , Ludes B , Maltret A , Mansencal N , Mansouri N , Marty J , Maury E , Maxime V , Megarbane B , Mekontso-Dessap A , Mira JP , Monnet X , Ngoyi N , Perier MC , Piot O , Plaisance P , Plu I , Prunet B , Raux M , Revaux F , Ricard JD , Richard C , Roussin F , Santoli F , Schortgen F , Sharifzadehgan A , Teboul JL , Timsit JF , Tuppin P , Ursat C , Vieillard-Baron A , Voicu S , Wahbi K , Waldmann V 
Published: September 2020

Background:
Conflicting data exist regarding the benefit of urgent coronary angiogram and percutaneous coronary intervention (PCI) after sudden cardiac arrest, particularly in the absence of ST-segment elevation. We hypothesized that the type of lesions treated (stable versus unstable) influences the benefit derived from PCI.

Methods:
Data were taken between May 2011 and 2014 from a prospective registry enrolling all sudden cardiac arrest in Paris and suburbs (6.7 million inhabitants). Patients undergoing emergent coronary angiogram were included. Decision to perform PCI was left to the discretion of local teams. We assessed the impact of emergent PCI on survival at discharge according to whether the treated lesion was angiographically unstable or stable, and we investigated the predictive factors for unstable coronary lesions.

Results:

Among 9265 sudden cardiac arrests occurring during the study period, 1078 underwent emergent coronary angiogram (median age: 59.6 years, 78.3% males): 463 (42.9%) had an unstable lesion, 253 (23.5%) only stable lesions, and 362 (33.6%) no significant lesions. Emergent PCI was performed in 478 patients (91.4% of unstable and 21.7% of stable lesions). At discharge, PCI of unstable lesions was associated with twice-higher survival rate compared with untreated unstable lesions (47.9% versus 25.6%,
P
=0.013), while stable lesions PCI did not improve survival (25.5% versus 26.3%,
P
=1.00). After adjustment, PCI of unstable coronary lesions was independently associated with improved survival (odds ratio, 2.09 [95% CI, 1.42–3.09],
P
<0.001), contrary to PCI of stable lesions (odds ratio, 0.92 [95% CI. 0.44–1.87],
P
=0.824). Angina, initial shockable rhythm, ST-segment elevation, and absence of known coronary artery disease were independent predictors of unstable lesions.

Conclusions:
Emergent PCI of unstable lesions is associated with improved survival after sudden cardiac arrest, contrary to PCI of stable lesions. Accordingly, early PCI should only be performed in patients with unstable lesions. Four factors (chest pain, ST-elevation, absence of coronary artery disease history, and shockable initial rhythm) could help identify patients with unstable lesions who would, therefore, benefit from emergent coronary angiogram.