bluuebunny/crossref_metadata_2025_split huggingface dataset:
Location of Hospital Waste Disposal Site With FSWARA-GIS-MAIRCA Hybrid Algorithm
Authors: Pirbasti Fatemeh Ramila Heydari , Modiri Mahmoud , Hafashjani Kiamars Fathi , Komijan Alireza Rashidi 
Published: February 2020

Abstract
Background: One of the major environmental issues facing most societies is the management of waste, industrial, medical and hazardous waste. Locating is an activity that analyzes the capabilities of an area in terms of whether the land is suitable for a particular application. The metrics used in location vary by application type, but they are all aligned to select the right location. Choosing the right burial site for waste is the most important step in waste management. Inappropriate burial selection causes contamination of water, soil and air in the area. The ultimate goal is to find the most suitable location that has the least impact on the environment and natural resources around, and is economically the least costly and engineered. Results: In this study, we chose south of Tehran as a case study to implement the FSWARA-GISMAIRCA Hybrid Algorithm. Selecting inappropriate locations for hospital waste disposal site at the southeast of Tehran province is one of the environmental problems of this region causing damage to the environment and pollution of ground waters. Since waste disposal site is the most economic, accepted, and important method in most areas, the present study aimed to locate the hospital waste disposal site at the southeast of Tehran province. Using fuzzy Delphi method, nine criteria (slope, height, soil type, distance from fault, distance from surface water, depth of ground waters, distance from residential areas, distance from hospitals and distance from road) were finally selected as the final criteria. Then, the desired criteria were weighed using the FSWARA and entered the GIS system as information layers to calculate the final maps for the appropriate zones, which eight locations were selected for waste disposal site. Conclusions: Finally, using the MAIRCA method, the selected locations were ranked and finally among these eight locations, the fourth point was selected as the final location for hospital waste disposal site at the southeast of Tehran. According to the desired criteria with 34 degree slope, 1008 meters high, 3.4841 meters distance from fault, 8.4428 meters distance from surface water, 12 meters depth of ground waters, 457 meters distance from residential areas, 6.4749 meters distance from hospitals, and 1598 meters distance from road.
Cardiovascular Disease Prediction from Electrocardiogram by using Machine Learning Method: A Snapshot from the Subjects of the Malaysian Cohort
Authors: Nayan Nazrul Anuar , Hamid Hafifah Ab , Suboh Mohd Zubir , Abdullah Noraidatulakma , Jaafar Rosmina , Yusof Nurul Ain Mhd , Hamid Mariatul Akma , Zubiri Nur Farawahida , Arifin Azwa Shawani Kamalul , Daud Syakila Mohd Abd , Kamaruddin Mohd Arman , Jamal Rahman A 
Published: February 2020

Abstract
Background: Cardiovascular disease (CVD) is the leading cause of deaths worldwide. In 2017, CVD contributed to 13,503 deaths in Malaysia. The current approaches for CVD prediction are usually invasive and costly. Machine learning (ML) techniques allow an accurate prediction by utilizing the complex interactions among relevant risk factors. Results: This study presents a case–control study involving 60 participants from The Malaysian Cohort, which is a prospective population-based project. Five parameters, namely, the R–R interval and root mean square of successive differences extracted from electrocardiogram (ECG), systolic and diastolic blood pressures, and total cholesterol level, were statistically significant in predicting CVD. Six ML algorithms, namely, linear discriminant analysis, linear and quadratic support vector machines, decision tree, k-nearest neighbor, and artificial neural network (ANN), were evaluated to determine the most accurate classifier in predicting CVD risk. ANN, which achieved 90% specificity, 90% sensitivity, and 90% accuracy, demonstrated the highest prediction performance among the six algorithms. Conclusions: In summary, by utilizing ML techniques, ECG data can serve as a good parameter for CVD prediction among the Malaysian multiethnic population.
The prognostic role of tumor-infiltrating lymphocytes in urothelial carcinoma of bladder: A systematic review and meta-analysis
Authors: Yang Zhiqiang , Bai Yujin , Hu Xu , Han Ping 
Published: February 2020

Abstract
Background: Tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment are associated with different prognosis in various malignancies. However, their prognostic impact remains controversial in urothelial carcinoma of bladder (UCB). In this systematic review and meta-analysis, we aimed to investigate the prognostic value of TILs in UCB patients.Methods: A systematic review and meta-analysis was performed using Pubmed, Embase and Cochrane Library. Studies were eligible if they investigated the prognostic value of CD3+, CD4+, CD8+, Foxp3+ lymphocytes or TILs in UCB patients, by time-to-event survival analysis. All studies were appraised for risk of bias using the Quality and Prognosis Studies (QUIPS) criteria. Hazard rations (HRs) with their 95% confidence interval (CIs) from each study were used to generate pooled HRs. Results: A total of 14 studies assessing the impact of TILs on prognostic outcomes in UCB patients were included in final analysis. The pooled analysis indicated a favorable role of CD3+ TILs (HR 0.74 (95% CI 0.62-0.88) for overall survival) and CD8+ TILs (HR 0.46 (95% CI 0.28-0.74) for OS) in the clinical outcomes of UCB, while Foxp3+ TILs were associated with worse survival (HR 2.21 (95% CI 1.47-3.32) for recurrence-free survival). Conclusions: This systematic review and meta-analysis confirmed the favorable prognostic impact of CD3+ and CD8+ tumor-infiltrating T cells in UCB patients and found the association between Foxp3+ TILs and worse survival. Future studies using large cohorts and standardized methodology with regard to tumor subsites, stages and treatment modalities are needed to incorporate TILs with clinical practice.
circ-ANKS1B facilitates osteosarcoma cell proliferation and invasiveness via upregulating Ki-67 expression by sponging miR-149-5p
Authors: Yang Hao , Liu Yujie , Li Chao , Liu Yilin , Zhao Liang , Wang Yuqiang , Zhang Yang , Zhang Min , Wang Limin 
Published: February 2020

Abstract
Background: Mounting evidence has shown that Circular RNAs (circRNAs) are associated with initiation and progression of human cancers. However, the expression and function of circRNAs in the development of osteosarcoma (OS) remain unclear. Methods: In this study, the expression profiles of circRNA circ-ANKS1B in OS were identified through qRT-PCR and in situ hybridization (ISH). The relationships between expression of circ-ANKS1B and clinicopathological features of OS patients was analyzed. Cell proliferation potential, migration and invasion ability of OS cells were evaluated through CCK8, colony formation, transwell and wound healing assays in vitro. Xenograft nude mouse experiment was performed to investigate tumor formation ability in vivo. The downstream regulated microRNA of circ-ANKS1B was proved via qRT-PCR and dual-luciferase reporter. Results: We found expression of circ-ANKS1B was markedly overexpressed in OS cell lines and tumor tissues, and high expression of circ-ANKS1B was correlated with advanced TNM stage and poor prognosis of OS patients. The results of functional experiments showed that depletion of circ-ANKS1B could inhibit proliferation and invasion ability of OS cells in vitro, and tumor formation ability in vivo. Further mechanistic studies revealed that circ-ANKS1B could sponge endogenous miR-149-5p and partially reversed the suppressive effect of miR-149-5p in OS cells. Furthermore, we demonstrated that circ-ANKS1B regulated Ki-67 expression by sponging miR-149-5p. Conclusions: In summary, our data showed that circ-ANKS1B accelerated cell growth and invasion in OS by sponging miR-149-5p and regulating Ki-67.
Preservation and Clinical Study on Involved Teeth with Jaw Cyst
Authors: Niu Gang , Li Qing-ling , Tang Yong-gang , Lv Jing-jing , Lin Li-song , Lu You-Guang 
Published: February 2020

Abstract
Background To assess the efficacy of modified surgery in the preservation of tooth pulp affected by jaw cyst. Methods Fifty-four impacted teeth in 16 cases of jaw cyst treated by our department were selected between September 2015 and October 2016. We observed the pulps' activity in the involved teeth and the efficacy of surgery. Results Out of 54 impacted teeth in 16 patients, after 12-24 months’ follow-up,45 affected teeth recovered well, whereas nine teeth showed adverse symptoms such as redness and swelling in the apical area, fistula, and pain. These symptoms resolved after postoperative root canal therapy. Chewing function was restored well. The bone cavity gradually reduced and finally disappeared, and bone density returned to normal after long-term follow-up. ConclusionPreservation of the involved tooth pulp for the treatment of jaw cyst by performing an improved operation method was effective.
A Pilot Study Comparing Tools for Tracking Implementation Strategies and Treatment Adaptations
Authors: Walsh-Bailey Callie , Palazzo Lorella G. , Jones Salene M. W. , Mettert Kayne D. , Powell Byron J. , Stirman Shannon Wiltsey , Lyon Aaron R. , Rohde Paul , Lewis Cara C 
Published: February 2020

Abstract
Background Tailoring implementation strategies and adapting treatments to better fit the local context may improve their effectiveness. However, there is a dearth of valid, reliable, pragmatic measures that allow for the prospective tracking of strategies and adaptations according to reporting recommendations. This study describes the development and pilot testing of three tools to designed to serve this purpose. Methods Measure development was informed by two systematic reviews of the literature (implementation strategies, treatment adaptation). The three resulting tools vary with respect to the degree of structure (Brainstorming Log = low, Activity Log = moderate, Detailed Tracking Log = high). To prospectively track treatment adaptations and implementation strategies, three stakeholder groups (treatment developer, implementation practitioners, mental health providers) were randomly assigned one tool per week via an anonymous web-based survey for nine weeks and incentivized to participate. Three established implementation outcome measures, the Acceptability of Intervention Measure, Intervention Appropriateness Measure, and Feasibility of Intervention Measure were used to assess the tools. Semi-structured interviews were conducted to gather more nuanced information from stakeholders regarding their perceptions of the tools and the tracking process. Results The three tracking tools demonstrated moderate to good acceptability, appropriateness, and feasibility; the Activity Log was deemed the most feasible of the three tools. Implementation practitioners rated the tools the highest of the three stakeholder groups. The tools took an average of 15 minutes or less to complete. Conclusion This study sought to fill methodological gaps that prevent stakeholders and researchers from discerning which strategies are most important to deploy for promoting implementation and sustainment of evidence-based practices. These tools would allow researchers and practitioners to track whether activities were treatment adaptations or implementation strategies and what barrier(s) each target. These tools could inform prospective tailoring of implementation strategies and treatment adaptations, which would promote scale out and spread.
Tight junction protein ZO-1 in Kawasaki disease
Authors: Lai Wan-Tz , Huang Ying-Hsien , Lo Mao-Hung , Kuo Ho-Chang 
Published: February 2020

Abstract
BackgroundKawasaki disease (KD) is a form of systemic febrile vasculitis that can be complicated by coronary artery lesions (CAL). A murine model of KD vasculitis showed that the vasculitis depended on intestinal barrier dysfunction, as well as that the tight junctions maintain the intestinal barrier. In this study, we aimed to investigate the role of tight junction Zonula occludens-1 (Zo-1) in intravenous immunoglobulin (IVIG) treatment response and the occurrence of CAL formation in KD patients.MethodsForty KD patients, 12 healthy controls, and 12 febrile controls were enrolled in this study. Tight junction ZO-1 levels were measured in sera by enzyme-linked immunosorbent assay.ResultsThe serum Zo-1 level was higher in the fever control group but did not achieve statistical significance. Patients who received a second dose of IVIG due to a failure to respond to the initial IVIG treatment had a higher serum tight junction Zo-1 level, but also without statistical significance (p value =0.0582). Patients who developed a coronary artery lesion had a lower serum tight junction Zo-1 level with statistical significance (p value =0.0275).ConclusionsTight junction ZO-1 levels decrease in KD patients with coronary artery lesions and are associated with the intestinal barrier dysfunction of Kawasaki disease and the occurrence of CAL in KD patients.
Long non-coding RNA HAGLR inhibits growth and metastasis and reduces stemness of lung cancer cells through the microRNA-330-3p/SLC34A2 axis
Authors: Yang Chunxia , Chen Dukai , Zhong Xiaoling , Yang Fangding 
Published: February 2020

Abstract
Background Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide. Long noncoding RNAs (lncRNAs) are crucial regulatory molecules in diverse pathological processes, including cancer progression. This study was conducted to probe the influence of lncRNA HAGLR on the growth, metastasis and stemness of LC cells. Methods Aberrantly expressed lncRNAs in LC tissues were screened out using microarray analysis. HAGLR expression in LC tissues and cells and in the paired normal ones was determined using RT-qPCR. Overexpression of HAGLR was administrated in H1299 and A549 cells to identify its function in the biological characteristics of LC cells. Sub-cellular localization of HAGLR was determined, and the downstream molecules involved in the HAGLR-mediated events were predicted on a bioinformation system and validated through dual luciferase reporter gene assay. Results HAGLR was poorly expressed in both LC tissues and cells. Overexpression of HAGLR inhibited viability, proliferation and metastasis, and reduced the stemness of H1299 and A549 cells. HAGLR up-regulated SLC34A2 expression through sponging miR-330-3p, leading to further inactivation of the Wnt/β-catenin signaling pathway. Artificial activation of the Wnt/β-catenin pathway recovered the viability and promoted metastasis of LC cells inhibited by HAGLR Conclusion HAGLR serves as a competing endogenous RNA for miR-330-3p to upregulate miR-330-3p expression and inactivate the Wnt/β-catenin pathway, leading to inhibited growth and metastasis and reduced stemness of LC cells.
Characteristics of packaged water production facilities in Greater Accra, Ghana: implications for water safety and associated environmental impacts
Authors: Semey Maxwell D. K. , Dotse-Gborgbortsi Winfred , Dzodzomenyo Mawuli , Wright Jim 
Published: February 2020

Abstract
Packaged water (sold in bags or bottles) is widely consumed in many countries and is the main drinking-water source for most urban Ghanaian households. There are, however, few studies of packaged water production. This study aims to assess the source water, treatment, and manufacturing characteristics of sachet water (vended in 500 mL plastic bags), together with point-of-manufacture risks to hygienic production. A sample of 90 sachets was collected of brands sold in four neighbourhoods in Accra, Ghana, their packaging and physical characteristics recorded, and a risk score calculated from these. Production processes were observed at 60 associated sachet factories, producers interviewed, and surrounding neighbourhoods surveyed for contamination hazards. 80% of producers packaged groundwater from boreholes and all treated water via reverse osmosis. Almost all manufacturers (95%) reported site visits by regulators in the previous year and few risks to hygienic production were observed at factories. Sanitary risk scores were 9.2% higher at the seven factories never visited by a regulator, though this difference was not significant (t = 1.81; p = 0.07). This survey suggests most Ghanaian sachet water originates from groundwater and is comparatively safe, though a minority remains unregulated. Groundwater governance policy could support this industry in meeting Greater Accra's growing water demand through the designation of protected municipal wellfields.
Edible seed oil waste: status quo and future perspectives
Authors: Welz P. J. 
Published: February 2020

Abstract
Large volumes of process water and steam are required for extraction and refining of edible seed oils. Water usage in most industries has decreased over the years as increasing emphasis is being placed on water re-use in modern facilities. However, given the size of the edible seed oil industry globally, there is a lack of current quantitative data about water use and wastewater generation. As the world moves towards a circular economy and water becomes more scarce, it is imperative that the industry players provide meaningful input/output data in order to benchmark and identify areas for waste valorization. This review provides data currently available in the public domain on the specific wastewater intake and wastewater generation by the edible seed oil industry, highlighting the need for further data collection. In addition, wastewater quality and current and future wastewater treatment technologies are discussed, as well as the potential for valorization of solid waste and effluent from the industry, and potential avenues for future research.
Evaluation of the Diagnostic Properties of Serum hsa-miR-223-5p in the Detection of Gastric Cancer: A Case-Control Study
Authors: Aalami Amir H. , Pouresmaeil Vahid , Amirabadi Amir , Mojahed Fatemeh H. , Rad Mahdi Q. , Sahebkar Amirhossein 
Published: February 2020

Background:
MicroRNAs (miRs) are a group of small non-coding and single-stranded RNAs of 18
to 25 nucleotides. The study of microRNAs is one of the new ways to detect cancer. In this study, the serum
expression of miR-223 in patients with GC was measured and compared with the control group.

Methods:
This case-control study was conducted on 39 patients with GC and 39 control subjects who visited the
Reza Radiotherapy and Oncology Center, Mashhad, Iran, due to gastrointestinal complaints. The demographic
information was collected, and the serum levels of miR-223 were measured using the real-time PCR technique
in all study subjects. The association between the GC of miR-223 and tumor staging and cancer progression was
assessed.

Results:
The miR-223 expression in GC patients was 3.10-fold higher than that of the control group
(p<0.0001). The miR-223 expression was significantly higher in the GC stages and grades compared to the
control group (p<0.0001 each). However, there was no significant effect for age, smoking, and gender on miR-
223 expression in GC and controls. At the optimal cutoff value of 0.7436, the maximal sensitivity of 89.74%
and specificity of 84.62% were achieved for miR-223 (p<0.001). The sensitivity and specificity for miR-223 for
differentiating low grades from high grade were 92.31% and 73.08% (p=0.0003), and for differentiating low
stages from the high stage was 81.82% and 39.29% respectively (p=0.696).

Conclusion:
This study revealed that miR-223 could be considered as a non-invasive diagnostic marker in the
early diagnosis of GC.
Immunostimulating Activity of Gold-modified Nanodiamond Particles
Authors: Plotnikov Evgenii , Nina Skoryk , Daniil Savelyev , Plotnikov Vladimir 
Published: February 2020

Background:
The fight against infectious diseases includes two main components –
immediate direct anti-infective action and stimulation of one's own immunity.

Objective:
In this study, we investigated the properties of diamond nanoparticles modified with
gold. The use of such gold nanoparticles as indirect anti-infectious agents and immunostimulators
has certain prospects.

Materials and Methods:
Gold hydrosols were synthesized by the reduction in an aqueous solution
of gold (III) with sodium citrate (Na3Cit) under heating. Modification procedure of nanodiamond
by gold requires incubation, a small sample of nanodiamond in a defined volume of a gold sol for
about 24 hours in a dark place. We use human blood cells as test objects. The reaction of blastic
transformation of lymphocytes was applied here as a test of biological actions of modified nanodiamond.

Results:
Modified nanodiamond do not have a toxic influence on blood cells. Modified nanodiamond
possesses stimulation effects on spontaneous proliferation of lymphocytes and does not significantly
affect phytohemagglutinin-induced proliferation. Nanodiamond slightly increases phagocytosis
parameters of neutrophil leucocytes.

Conclusion:
Thus, results showed that the nanodiamond modified by gold possesses immunostimulating
activity, increases the phagocytic activity of neutrophilic leukocytes and stimulates lymphocytes
in the spontaneous proliferation test. Gold-modified nanodiamond could be considered as
a non-direct anti-infective agent through immune stimulation.
Role of Vitamins in Biotransformation for Human Health
Authors: Köse Merve Deniz , Ak Büsra , Atak Eylem , Bayraktar Oguz 
Published: February 2020

Objective:
Vitamins are nutraceutical groups involved in important processes that
provide energy production, strengthening the immune system, fighting free radicals, the production
of red blood cells. Biotransformation is a process involving the use of biological agents as catalysts
to perform the transformation of chemical compounds. Biotransformation processes offer
advantages as high regioselectivity, stereospecificity, and mild operating conditions when
compared to chemical reactions. In most cases, the aim of using biotransformation is to introduce
chirality into a molecule, to achieve a regioselective functionalization or to selectively convert a
functional group among other groups with similar reactivity. The biotransformation of vitamins
can be defined as the sum of the processes by which vitamins are altered by the biological
reactions in the body. Biotransformation leading to a new way of synthesis of vitamins has recently
been studied. In the literature, there are various studies about using vitamins as nutraceuticals.

Methods:
The role of vitamins in the biotransformation can be diversified. They can be a source or
final product in the biotransformation. In the present study, various roles of vitamins in the
biotransformation were explained.

Results:
When it is compared with traditional methods, obtained data showed that with
biotransformation properties such as; activity of the vitamins, nutritional value of the food and
productivity of the process were increased.

Conclusion:
Even though the biotransformation of vitamins has been studied, there is no review
paper about the biotransformation of vitamins and their benefits. In this review, the
biotransformation of vitamins and vitamins that are used in the biotransformation were mentioned.