bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ and healthcare workers’ recommendations for a surgical patient safety checklist – a qualitative study
Authors: Harris Kristin , Søfteland Eirik , Moi Asgjerd Litleré , Harthug Stig , Storesund Anette , Jesuthasan Sebastius , Sevdalis Nick , Haugen Arvid Steinar 
Published: January 2020

AbstractBackgroundPatients’ involvement in patient safety has increased in healthcare. Use of checklists may improve patient outcome in surgery, though few have attempted to engage patients’ use of surgical checklist. To identify risk elements of complications based on patients’ and healthcare workers’ experiences is warranted. This study aims to identify what the patients and healthcare workers find to be the risk elements that should be included in a patient-driven surgical patient safety checklist.MethodA qualitative study design where post-operative patients, surgeons, ward physicians, ward nurses, and secretaries from five surgical specialties took part in focus group interviews. Eleven focus groups were conducted including 25 post-operative patients and 27 healthcare workers at one tertiary teaching hospital and one community hospital in Norway. Based on their experiences, participants were asked to identify perceived risks before and after surgery. The interviews were analysed using content analysis.ResultsSafety risk factors were categorised as pre-operative information: pre-operative preparations, post-operative information, post-operative plans and follow-up. The subcategories under pre-operative information and preparations were: contact information, medication safety, health status, optimising health, dental status, read information, preparation two weeks before surgery, inform your surgical ward, planning your own discharge, preparation on admission and just before surgery. The subcategories under post-operative information, further plans and follow-up were: prevention and complications, restriction and activity, medication safety, pain relief, stomach functions, further care and appointments. Both healthcare workers and patients express the need for a surgical patient safety checklist.ConclusionA broad spectre of risk elements for a patient safety checklist were identified. Developing a surgical safety checklist based on these risk elements might reduce complications and unwanted errors.Trail registrationThe study is registered as part of a clinical trial inClinicalTrials.gov: NCT03105713.
Cost-effectiveness analysis of pembrolizumab compared to standard of care as first line treatment for patients with advanced melanoma in Hong Kong
Authors: Loong Herbert H. , Wong Carlos K. H. , Leung Linda K. S. , Tan S. C. , Jen Jason , Lee Mary Y. K. , Aguiar-Ibáñez Raquel , Wang Jingshu 
Published: January 2020

AbstractBackgroundPembrolizumab has been shown to improve overall survival (OS) and progression free survival (PFS) compared to ipilimumab in patients with ipilimumab-naïve advanced melanoma; however, there are no published data on the cost-effectiveness for pembrolizumab compared to standard-of-care treatments currently used in Hong Kong for advanced melanoma.MethodsA partitioned-survival model based on data from a recent randomized phase 3 study (KEYNOTE-006) and meta-analysis was used to derive time in PFS, OS, and post-progression survival for pembrolizumab and chemotherapy, such as dacarbazine (DTIC), temozolomide (TMZ), and the paclitaxel-carboplatin combination (PC). A combination of clinical trial data, published data, results of meta-analysis, and melanoma registry data was used to extrapolate PFS and OS curves. The base-case time horizon for the model was 30 years with costs and health outcomes discounted at a rate of 5% per year. Individual patient level data on utilities and frequencies of adverse events were obtained from the final analysis of KEYNOTE-006 (cut-off date: 3-Dec-15) for pembrolizumab. Cost data included drug acquisition, treatment administration, adverse event management, and clinical management of advanced melanoma. The distribution of patient weight from the Hong Kong population was applied to calculate the drug costs. Analyses were performed from a payer’s perspective. The incremental cost effectiveness ratio (ICER) expressed as cost in US Dollars (USD) per quality-adjusted life years (QALYs) was the main outcome.ResultsIn base-case scenario, the ICER for pembrolizumab as a first-line treatment for advanced melanoma was USD49,232 compared to DTIC, with the ICER values lower than cost-effectiveness threshold in Hong Kong. Results comparing pembrolizumab to TMZ and to PC were similar to that when compared to DTIC. Probability sensitivity analyses showed that 99% of the simulated ICERs were below three times the Gross Domestic Product (GDP) per capita for Hong Kong (currently at $119,274//QALY threshold). In a scenario analysis comparing pembrolizumab with ipilimumab, the estimated ICER was USD8,904.ConclusionsPembrolizumab is cost-effective relative to chemotherapy (DTIC, TMZ and PC), and highly-cost-effective compared to ipilimumab, for the first-line treatment of advanced melanoma in Hong Kong.
Long-term outcomes of limb salvage treatment with custom-made extendible endoprosthesis for bone sarcoma around the knee in children
Authors: Zou Changye , Zhao Zhiqiang , Lin Tiao , Huang Yongfu , Xie Xianbiao , Yin Junqiang , Huang Gang , Wang Bo , Shen Jingnan 
Published: January 2020

AbstractBackgroundLimb salvage for bone sarcoma around the knee in skeletally immature children is challenging because of interference on two critical growth plates in the lower limb. This retrospective study aims to evaluate long-term outcomes and influence on growth of the lower limb of the cemented extendible endoprostheses.MethodsForty-five children with bone sarcoma around the knee, who underwent custom-made extendible endoprosthesis replacements, were included in this study. The average follow-up was 10.1 years. Survival, prosthetic-related complications and revision, functional outcomes, and influence on growth by prosthesis implantation were recorded.ResultsThe 5-year disease-free survival and overall survival are 54.9% and 72.7%, and the 5-year prosthesis survival rate is 59.4%. The prosthesis was extended 4.2 cm in average. Limb length discrepancies of 20 patients were within 2 cm, and growth inhibition of proximal tibial epiphysis by passive implant insertion was observed. Aseptic loosening in 7 patients was the most significant complication. The Musculoskeletal Tumor Society score at last visit was 83.2%.ConclusionsThe use of custom-made extendible endoprosthesis provided good functional results for children with bone tumor around the knee. Further improvement of the prosthesis design and operation technique will help to decrease complication and gain better limb function.
A novel approach for T7 bacteriophage genome integration of exogenous DNA
Authors: Liu Ying , Huang Hongxing , Wang Hua , Zhang Yan 
Published: January 2020

Abstract
Background
The comparatively small genome, well elucidated functional genomics and rapid life cycle confer T7 bacteriophage with great advantages for bio-application. Genetic manipulation of T7 genome plays a key role in T7 related applications. As one of the important aspects in T7 phage genetic modification, gene knock-in refers to two main approaches including direct genetic manipulation in vitro and recombineering. Neither of these available methods are efficient enough to support the development of innovative applications capitalizing on T7 bio-system and thus there is room for novel strategies that address this issue. Integration mediated by the ΦC31 integrase is one of the most robust site-specific recombination systems. ΦC31 integrases with enhanced activity and specificity have been developed such that it is ideal to effectuate exogenous DNA knock-in of T7 phage with advanced ΦC31 integrase.

Methods
Plasmid construction was conducted by routine molecular cloning technology. The engineered T7 bacteriophages were constructed through homologous recombination with corresponding plasmids and the functional T7 phage was designated as T7∆G10G11-attB. In the integration reaction, hosts with both executive plasmids (pEXM4) and donor plasmids (pMCBK) were lysed by T7∆G10G11-attB. Progenies of T7 phages that integrated with pMCBK were isolated in restrict hosts and validated by sequencing. T7∆G10G11-attB capacity limit was explored by another integration reactions with donor plasmids that contain exogenous DNA of various lengths.

Results
T7∆G10G11-attB exhibits abortive growth in restrictive hosts, and a bacterial attachment site recognized by ΦC31 integrase (attB) was confirmed to be present in the T7∆G10G11-attB genome via sequencing. The integration reaction demonstrated that plasmids containing the corresponding phage attachment site (attP) could be integrated into the T7∆G10G11-attB genome. The candidate recombinant phage was isolated and validated to have integrated exogenous DNA. The maximum capacity of T7∆G10G11-attB was explored, and it’s found that insertion of exogenous DNA sequences longer than 2 kbp long can be accommodated stably.

Conclusion
We advanced and established a novel approach for gene knock-in into the T7 genome using ΦC31 integrase.
High risk of macrosomia in newborns of immigrant mothers
Authors: De Curtis Mario , Villani Leonardo , Polo Arianna 
Published: January 2020

Abstract
Background
In Italy live about 8.7% immigrants, which contribute to more than 15% of all deliveries taking place in Italy. We aimed to investigate whether newborns from high migratory pressure countries (HMPC) mothers have a different macrosomia and post-term pregnancy incidence compared to Italian newborns.

Methods
In this retrospective observational study, we analyzed data on 404.863 babies born between 2010 and 2017. Italian mothers delivered 309.658 (76.5%), HMPC mothers 88.179 (21.8%) and developed country (DC) mothers 7.026 (1.7%) babies. We analyzed the incidence of macrosomia and post term pregnancy.
We estimated incidence rate (IR), unadjusted incidence rate ratio (IRR) and 95% confidence intervals (CIs) to evaluate the association between these perinatal parameters and the mother’s region of birth.

Results
HMPC compared to Italian newborns showed a significantly higher incidence of birthweight > 4000 g (53.3‰ vs 39.1‰, p-value < 0.001; IRR 1.4, 95%CI = 1.36–1.45), birthweight ≥4500 g. (7.0‰ vs 3.8‰, p-value < 0.001; IRR 1.8, 95%CI = 1.67–2.0) and gestational age at birth > 41 weeks (19.9‰ vs 12.8‰, p-value < 0.001; IRR 1.55, 95%CI = 1.47–1.64).
The macrosomia incidence between HPMC and Italian newborns was significantly increased at all gestational ages (Fig. 1), especially for mothers coming from Central Eastern Europe (121.79‰ vs 91.1‰, p-value< 0.001; IRR 1.34, 95%CI = 1.11–1.62).

Conclusion
In Italy immigrant status represents a risk factor for macrosomia and post-term birth, which could be related to socio-economic status and unfavorable life conditions of immigrant mothers during pregnancy.
Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis
Authors: Semahegn Agumasie , Torpey Kwasi , Manu Adom , Assefa Nega , Tesfaye Gezahegn , Ankomah Augustine 
Published: January 2020

Abstract
Background
Major psychiatric disorders are growing public health concern that attributed 14% of the global burden of diseases. The management of major psychiatric disorders is challenging mainly due to medication non-adherence. However, there is a paucity of summarized evidence on the prevalence of psychotropic medication non-adherence and associated factors. Therefore, we aimed to summarize existing primary studies’ finding to determine the pooled prevalence and factors associated with psychotropic medication non-adherence.

Methods
A total of 4504 studies written in English until December 31, 2017, were searched from the main databases (n = 3125) (PubMed (MEDLINE), Embase, CINAHL, PsycINFO, and Web of Science) and other relevant sources (mainly from Google Scholar, n = 1379). Study selection, screening, and data extraction were carried out independently by two authors. Observational studies that had been conducted among adult patients (18 years and older) with major psychiatric disorders were eligible for the selection process. Critical appraisal of the included studies was carried out using the Newcastle Ottawa Scale. Systematic synthesis of the studies was carried out to summarize factors associated with psychotropic medication non-adherence. Meta-analysis was carried using Stata 14. Random effects model was used to compute the pooled prevalence, and sub-group analysis at 95% confidence interval.

Results
Forty-six studies were included in the systematic review. Of these, 35 studies (schizophrenia (n = 9), depressive (n = 16), and bipolar (n = 10) disorders) were included in the meta-analysis. Overall, 49% of major psychiatric disorder patients were non-adherent to their psychotropic medication. Of these, psychotropic medication non-adherence for schizophrenia, major depressive disorders, and bipolar disorders were 56%, 50%, and 44%, respectively. Individual patient’s behaviors, lack of social support, clinical or treatment and illness-related, and health system factors influenced psychotropic medication non-adherence.

Conclusion
Psychotropic medication non-adherence was high. It was influenced by various factors operating at different levels. Therefore, comprehensive intervention strategies should be designed to address factors associated with psychotropic medication non-adherence.

Systematic review registration
PROSPERO CRD42017067436
Infinitely many solutions for a Hénon-type system in hyperbolic space
Authors: Cunha Patrícia Leal da , Lemos Flávio Almeida 
Published: January 2020

AbstractThis paper is devoted to studying the semilinear elliptic system of Hénon type
$$ \textstyle\begin{cases} -\Delta _{\mathbb{B}^{N}}u= K(d(x))Q_{u}(u,v), \\ -\Delta _{\mathbb{B}^{N}}v= K(d(x))Q_{v}(u,v), \\ \quad u, v\in H_{r}^{1}(\mathbb{B}^{N}),\quad N\geq 3, \end{cases} $${−ΔBNu=K(d(x))Qu(u,v),−ΔBNv=K(d(x))Qv(u,v),u,v∈Hr1(BN),N≥3, in the hyperbolic space $\mathbb{B}^{N}$BN, where $H_{r}^{1}(\mathbb{B} ^{N})=\{u\in H^{1}(\mathbb{B}^{N}): u \text{ is radial}\}$Hr1(BN)={u∈H1(BN):u is radial} and $-\Delta _{\mathbb{B}^{N}}$−ΔBN denotes the Laplace–Beltrami operator on $\mathbb{B}^{N}$BN, $d(x)=d_{\mathbb{B}^{N}}(0,x)$d(x)=dBN(0,x), $Q \in C^{1}( \mathbb{R}\times \mathbb{R},\mathbb{R})$Q∈C1(R×R,R) is p-homogeneous, and $K\geq 0 $K≥0 is a continuous function. We prove a compactness result and, together with Clark’s theorem, we establish the existence of infinitely many solutions.
Use of urinary naloxone levels in a single provider practice: a case study
Authors: Warrington Jill S. , Booth Kaitlyn , Warrington Gregory S. , Francis-Fath Samuel 
Published: January 2020

Abstract
Background
Urine drug monitoring for medications for opioid use disorder (MOUD) such as buprenorphine can help to support treatment adherence. The practice of introducing unconsumed medication directly into urine (known as “spiking” samples) has been increasingly recognized as a potential means to simulate treatment adherence. In the laboratory, examination of the ratios of buprenorphine and its metabolite, norbuprenorphine, has been identified as a mechanism to identify “spiked” samples. Urine levels of naloxone may also be a novel marker in cases where the combination buprenorphine–naloxone product has been administered. This case study, which encompasses one provider’s practice spanning two sites, represents a preliminary report on the utility of using urinary naloxone as an indicator of “spiked” urine toxicology samples. Though only a case study, this represents the largest published evaluation of patients’ naloxone levels to date.

Case presentation
Over a 3-month period across two practice sites, we identified 1,223 patient samples with recorded naloxone levels, spanning a range of 0 to 12,161 ng/ml. The average naloxone level was 633.65 ng/ml with the majority (54%) of samples < 300 ng/ml. 8.0% of samples demonstrated extreme values of naloxone (> 2000 ng/ml). One practice site, which had increased evidence of specimen tampering at collections, had a greater percent of extreme naloxone levels (>  2000 ng/ml) at 9.3% and higher average naloxone level (686.8 ng/ml), in contrast to a second site (570.9 ng/ml; 6.4% at > 2000 ng/ml) that did not have known reports of specimen tampering.

Conclusions
We postulate that naloxone may serve as an additional flag to identify patient “spiking” of urine samples with use of the combination product of buprenorphine–naloxone.
Age estimation by pulp to tooth area ratio in canine teeth using cone-beam computed tomography
Authors: Salemi Fatemeh , Farhadian Maryam , Askari Sabzkouhi Bahare , Saati Samira , Nafisi Nika 
Published: January 2020

AbstractBackgroundThis study aimed to estimate the chronological age of individuals according to the correlation of age with morphological variables of the maxillary canine teeth using cone-beam computed tomography (CBCT) based on Kvaal’s method.MethodThis study was conducted on CBCT scans of 300 patients in Hamadan city, including 142 females and 158 males between 14 and 60 years of age. To measure the morphological variables, cross-sectional views of the maxillary right canine tooth were studied. The pulp to tooth area ratio (AR), the pulp to tooth length ratio (P), the mesiodistal and the buccolingual pulp to tooth width ratio at the cementoenamel junction (CEJ) (A1, A2), the mesiodistal and buccolingual pulp to tooth width ratio at the mid-root (C1, C2), and the mesiodistal and buccolingual pulp to tooth width ratio at the midpoint between the CEJ and the mid-root (B1, B2) were measured on CBCT scans.ResultsA significant inverse correlation was noted between age and all measured variables. No significant difference was found in the mean variables between males and females. The correlation between the actual age and estimated age in the regression model was 0.88. The mean square error (MSE) of prediction was 5.89 years; also, the mean absolute error (MAE) was 4.46 years.ConclusionThe fitted regression model suggested in this study can estimate the age of individuals with acceptable accuracy and mean absolute error of lower than 5 years.
The prevalence of catatonic syndrome in acute psychiatric wards
Authors: Takács Rozália , Asztalos Márton , Ungvari Gabor , Antosik-Wójcińska Anna , Gazdag Gábor 
Published: January 2020

Cel pracyCelem tego prospektywnego badania było ustalenie częstości występowania zespołów katatonicznych w populacji pacjentów ostroprzyjęciowych oddziałów psychiatrycznych na Węgrzech.MetodaPacjenci przyjęci w trybie nagłym do Centrum Psychiatrii i Leczenia Uzależnień, Szent Istvan i Szent Laszlo Hospitalsbyli przez okres 4-miesięcy poddawani ocenie w kierunku występowania u nich objawów katatonicznych. Przedmiotowe i podmiotowe objawy katatoniczne były oceniane według kryteriów diagnostycznych DSM-5 i Skali Oceny Katatonii Busha-Francisa (Bush Francis Catatonia Rating Scale, BFCRS). Rozpoznania zostały ustalone przy zastosowaniu ustrukturalizowanego wywiadu klinicznego (StructuredClinical Interview for DSM-IV Disorders, SCID), testu rysowania zegara i Krótkiej Skali Oceny Stanu PsychicznegoMini-Mental (MMSE).WynikiW okresie prowadzenia badania do wskazanych powyżej oddziałów w trybie nagłym przyjęto342 pacjentów. Rozpowszechnienie zespołów katatonicznych wynosiło 8,55% i 5,02%, odpowiednio według skali BFCRS i kryteriów DSM-5.WnioskiStwierdzona częstość występowania katatonii w populacji pacjentów przyjmowanych w trybie nagłym do oddziałów szpitalnych jest zgodna z szerokim zakresem wartości podanym w literaturze. Warto zwrócić uwagę na różnicę pomiędzy wynikami oceny w standaryzowanej w tym celu skali BFCRS a rutynową oceną kliniczną (DSM-5), co może wskazywać, że istotny odsetek przypadków katatonii nie jest w praktyce klinicznej rozpoznawany. Ponieważ ostra śmiertelna katatonia może być skutecznie leczona, a wczesne wdrożenie leczenia może zapobiec potencjalnie zagrażającym życiu powikłaniom, prawidłowe rozpoznanie objawów katatonicznych ma niezwykle istotne znaczenie.
Measurement of Static Lateral Stability Angle and Roll Moment of Inertia for Agricultural Tractors with Attached Implements
Authors: Nguyen Nang Van , Harada Yasuhiro , Takimoto Hiroki , Shimomoto Kota 
Published: January 2020

Highlights Keywords: Implement, Inertial parameter, Lateral stability, Moment of inertia, Rollover, Tractor.Static lateral stability of agricultural tractors with mounted rotary tillers was analyzed. Keywords: Implement, Inertial parameter, Lateral stability, Moment of inertia, Rollover, Tractor.The mounted implement increased static lateral stability of tractors in phase I rollover but decreased static lateral stability in phase II rollover. Keywords: Implement, Inertial parameter, Lateral stability, Moment of inertia, Rollover, Tractor.A mounted implement may significantly reduce the static lateral stability of agricultural tractors and increase the risk of tractor side overturn. Keywords: Implement, Inertial parameter, Lateral stability, Moment of inertia, Rollover, Tractor. ABSTRACT. Each year, many fatalities result from rollovers of agricultural tractors in Japan. In addition to rollover protective structures (ROPS) and seat belts, a warning device that alerts the operator of impending rollover based on the tractor stability index is a measure used to prevent rollovers. The stability index requires inertial parameters, which have been measured only for the single body of the tractor, to calculate the warning threshold. In this study, the center of gravity (CoG) and lateral stability angles of three agricultural tractors were measured, and lateral stability angles were also calculated and compared with measured values for three tractor-tiller combinations to analyze the effect of the attached implement on the tractor stability as well as to verify the accuracy of the calculation methods. The roll moment of inertia (RMI) was also measured for two tractors and two rotary tillers, and RMI values for tractor-tiller combinations were calculated. The measurement and calculation results show that the attached implement increased the lateral stability angle of tractors in phase I rollover and decreased the lateral stability angle in phase II rollover, and for a certain tractor-tiller combination, there was no transition from phase I to phase II rollover. The difference between the measured and calculated lateral stability angles in phase I ranged from -3.5° to 2.5°, while that in phase II ranged from 0.2° to 5.2°. The RMI about the longitudinal axis through the CoG was 203 and 433 kg m-2 for tractors A and B, respectively, and 52 and 94 kg m-2 for rotary tillers D and F, respectively. The calculated RMI values were 265 and 540 kg m-2 for tractor-tiller combinations A-D and B-E, respectively. Keywords: Implement, Inertial parameter, Lateral stability, Moment of inertia, Rollover, Tractor.
Editorial: Response to “ROPS Are Not Homemade”
Authors: Sanderson Wayne T. , Mazur Joan M. , Vincent Stacy K. , Byrd A. Preston 
Published: January 2020

Abstract. We are writing in response to the editorial “ROPS Are Not Homemade” by W. E. Field, R. Tormoehlen, S. Ehlers, C. Cheng, A. Talbert, G. Deboy, D. Haberlin, and C. V. Schwab, which was published in the July 2019 issue of the Journal of Agricultural Safety and Health (Field et al., 2019). The editorial warns secondary school teachers and FFA advisors about the potential liability of fabricating and installing low-cost rollover protective structures (ROPS) as service learning projects for agricultural education students. The apparent intent of the editorial is to discourage teachers and advisors from carrying out such projects. We wish to present arguments as to why these are actually highly beneficial projects to undertake, and perhaps one of our best hopes for significantly reducing the number of tractor overturn injuries and fatalities by directly involving our nation’s youth. Keywords: Homemade ROPS, ROPS, Tractor overturns.