bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN PERANGKAT PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN SIMULASI KOMPUTER MATERI ATOM, ION, DAN MOLEKUL UNTUK MENINGKATKAN HASIL BELAJAR SISWA SMP
Authors: Syahri Syahri , Madlazim Madlazim , Rachmadiarti Fida 
Published: February 2020

This research aims to produce a feasible guided inquiry instructional materials by using computer simulation to improve student’s learning achievement of junior high school. The application of computer simulation used consists of PhET (Sims Build an Atom), Jmol, and Periodic Table. Development of this instructional material refers to Dick and Carey’s model. The subjects of this research was instructional materials that consist of syllabus, lesson plan, student’s worksheet, textbook, and achievement test. It was conducted to IX grade students in junior high school. The data were collected using questionnaire, observation, and test. The data were analyzed using descriptive qualitative and quantitative statistic technique. The results of this research reveal that: (1) the instructional materials which is developed categorized very valid; (2) learning implementation categorized very good; (3) cognitive domain of the students’ learning achievement have increased by a score of N-gain high category; and (4) the students responded positively towards learning. Based on this results, it can be concluded that the guided inquiry instructional materials by using computer simulation which have been developed feasible used to improve student’s learning achievement.
PENGEMBANGAN LEMBAR KERJA SISWA MODEL INKUIRI TERBIMBING MATERI ELEKTROKIMIA KELAS XII SMA
Authors: Tuqa Eka Tina Nur Ula , Suyono Suyono , Sugiarto Bambang 
Published: February 2020

This research aimed to develop valid, practical, and effective worksheet to support electrochemistry learning using guided inquiry model. Development of worksheet based on ADDIE model (Analyse, Design, Develop, Implement, and Evaluate). Worksheet were implemented at grade XII chemistry students using one group pretest-posttest design. Validity of worksheet was measured from relevance and consistency based on expert judgment with minimum score of 2,6. Practicality of worksheet was measured from students activity with minimun percentage of 60%. Effectivenes of worksheet was measured from its impact to increase student’s cognitive achievement significanly. Validity and practicality was analyzed using descriptive statistics, whereas effectiveness of cognitive achievement was analyzed using inferential t-test. The result of data analysis were: (1) content validiy and construct validity of worksheet developed was very valid; (2) students activity were very good; (3) cognitive achievement has increased significanly both in pilot implementation and final implementation
JAVANESE GRADED READING BOOKS FOR ELEMENTARY SCHOOL STUDENTS
Authors: Supartinah Supartinah , Kawuryan Sekar Purbarini , Hastuti Woro Sri 
Published: February 2020

This research was intended to develop graded readers (graded reading books) in the Javanese language for elementary school students. To develop the products, this work usedthe R&D model by Borg and Gall, in which the main procedure was composed of product analysis, product development, expert validation, trials, and product revision. The subjects of this research were the elementary school students and the teachers of Bantul Regency, Sleman Regency, the City of Yogyakarta; experts in the Javanese language;experts in teaching and learning; and experts inteaching and learning media. The sample respondents were obtained through purposive sampling and the data were collected through questionnaires, observations, and interviews. The data were analyzed qualitatively and quantitatively. The products were validated by experts in learning contents, experts in teaching and learning, and experts in teaching and learning media. The result shows that they rated the products very good. The results of questionnaires distributed amongthe teachers and students show that these products carry positive impact on student learning.It can be concluded that the graded reading books are highly recommended for learning activitiesin elementary schools that offer Javanese.
Denture Induced Stomatitis-A Case Report
Authors: Inayat Ahsan , Hassan Syed Zahid , Aziz Ayesha , Ibrahim Rida 
Published: February 2020

Background: Denture hygiene habits are liable to change from one person to another. There has been a close relationship between irregular denture surfaces, poor oral hygiene or ill-fitted denture and opportunistic oral microorganism which leads to diseases like denture induced stomatitis.
Case Presentation: A 70-year-old patient reported to the Department of Prosthodontics with a chief complaint of broken denture and pain in oral mucosa. The patient history, oral and denture examination indicated that the patient had denture stomatitis.
Management & Results: The patient was advised to have good oral hygiene and anti-microbial gels. After a week of follow up, the patient showed good results with the treatment.
Conclusion: It can be concluded that the patient needs to be educated regarding denture and oral hygiene is the most important step to prevent this type of disease.
Oxidative stress mediated neurodegeneration; A cellular perspective
Authors: Noushad Shamoon , Sajid Ujala , Ahmed Sadaf , Saleem Yusra 
Published: February 2020

Background: Environmental toxins, nutritional discrepancies, genetic predispositions, and lifestyle modifications induce a variety of stresses on the human brain and body. Such chronic stressors can influence the onset and progression of neurodegeneration via cellular alterations. In this systematic review, we have discussed the role of oxidative stress in causing neurodegeneration. Moreover, the chemical, metallic and other etiological factors that stimulate oxidative stress and results in the development of neurodegenerative disorders are also explored and summarized.
Methodology: A systematic review was conducted to investigate the impact of oxidative stress on the human brain in relation to neurodegeneration. The human studies focusing on neurobiology and cellular changes in brain, investigating the pathway of oxidative stress leading to neurodegeneration through mitochondrial dysfunction and cellular alterations, published during 1st January 2000 to 31st March 2019 were identified and included in this systematic review.
Result: Following the PRISMA guidelines, 13 out of 1169 studies met the eligibility criteria and were included in the quantitative synthesis and screening. These studies focused on the features like cellular factors, metal exposure, and aging, inducing oxidative stress-related neurodegeneration. 6 studies described mitochondrial alterations resulting in oxidative stress due to an increase in the production of reactive oxygen species (ROS), oxidation of proteins, peroxidation of lipid and damages to the deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). While the data from 5 studies suggested the loss of mitochondrial activity in response to metal exposure. 2 experimental studies specified the effect of aging and self-implication of oxidative stress in the brain.
Conclusion: Although there are sufficient evidence that supported the hypothesis that stress is significantly associated with neurodegeneration but it is still not considered as a primary instigator in neurodegenerative disorders. However, it can be concluded on the basis of this review that it has been involved in the propagation of cellular alterations and mitochondrial dysfunction that further leads to neurodegeneration.
Comparative safety and efficacy of low dose ketamine and opioids for acute pain management at the emergency department
Authors: Asim Syed Jehanzeb , Muhammad Aqil  , Ali Wajahat , Shehbaz Lal , Nasir Shua 
Published: February 2020

Background: Pain is a complex phenomenon for which many pharmacological agents have been discovered and utilized for pain relief. Ketamine is a more preferred pain reliever over opioids in the emergency department (ED). The aim of this study was to compare the safety and efficacy of low dose ketamine (LDK) with morphine (opioid) for pain relief among patients presenting to the ED.
Methodology: A prospective, cohort study was conducted over a sample of 280 patients presented with acute pain to the ED, Ziauddin University Hospital, Karachi. These patients were then divided into two groups via simple random sampling with randomization being assured using an online randomizer software tool. The 1st group (n=140) was given 0.2 mg/kg of LDK while 0.1 mg/kg of intravenous morphine (opioid) was given to the 2nd group (n=140). The pain intensity was measured using the Visual Analogue Scale (VAS) from admission to 60 mins, the records were taken after every 15 mins. The adverse events (AE’s) were also recorded for both groups. The data was then analyzed using SPSS Version 21 & Microsoft Excel 2016.
Results: Out of 280 patients enrolled in the study, there was male majority i.e. 76.07% while the remaining were females with the mean age of 29±7 years. Within 15 minutes of initial dose administration in both groups, a marked reduction in pain intensity was observed. Reduced respiratory rate, pruritus and decreased O2 saturation were common AE’s observed, which were comparatively higher among patients receiving morphine as compared to ketamine.
Conclusion: The efficacy of morphine (opium) and LDK is similar in alleviating pain in an emergency setting, however, LDK is visibly safer than its opioid counterpart and thus may be used as a safer alternative.
Healthy live birth following ICSI with retrograde ejaculated cryopreserved sperm
Authors: Barkat Neelam , Ahmed Maria , Khan Safdar , Iqbal Anila , Paul Sadia 
Published: February 2020

Background: Retrograde ejaculation is a medical condition that occurs when semen enters the urinary bladder(retrograde) during orgasm instead of passing through the penis (antegrade). Complete retrograde semen flow causes male infertility. An advanced technique intracytoplasmic sperm injection (ICSI) can be used to achieve fertilization in the case of male sub-fertility e.g. Oligo-Astheno-Teratozoospermia.
Case Presentation: A couple with primary infertility visited the concept fertility centre, where male was diagnosed with retrograde ejaculation for which ICSI was offered with back-up semen freezing after an initial semen analysis.
Management & Results: Female was stimulated with long stimulation protocol and thirteen matured eggs were injected by cryopreserved sperms extracted from urine sediment. Fertilization occurred in twelve eggs out of which two good quality embryos were transferred after day five in vitro culturing and rest were vitrified. The patient conceived triplets and gave birth at 33 weeks, but two babies had neonatal death within four days and the patient has one healthy baby girl.
Conclusion: Applying assisted reproductive techniques to aid pregnancy in cases of retrograde ejaculation has paucity of knowledge in Pakistan and this case report is the first in Pakistan to describe the diagnosis and successful treatment of infertile couples, with advanced reproductive technology, where the male partner suffered from retrograde ejaculation.
2.7 Machine Learning on Central Hemodynamic Quantities Using Noninvasive Measurements: How Far Can We Go?
Authors: Bikia Vasiliki , Pagoulatou Stamatia , Stergiopulos Nikolaos 
Published: February 2020

Abstract
Background
Transforming peripheral noninvasive measurements to obtain central hemodynamic quantities, such as cardiac output (CO) and central systolic blood pressure (cSBP), is a highly emerging field [1,2]. However, no holistic investigation has been performed to assess the amount of information contained in each peripheral measurement for the prediction of central values. This can be attributed to the inherent difficulty of creating a complete and accurate database; mainly due to the invasive nature of the gold standard techniques [3,4].

Methods
To meet this need, we exploit synthetic data from a previously validated cardiovascular model (CVm) [5]. Our study relies on peripheral quantities including brachial pressure, heart rate (HR), and pulse wave velocity (PWV) simulated by the CVm. A Random Forest model was trained using 2744 synthetic instances and, subsequently, was tested against a subset of 800. Correlations and feature importances of the input parameters were reported (Figure 1).

Results
Our results demonstrated that precise estimates of CO and cSBP were yielded with an RMSE of 0.39 L/min and 1.39 mmHg, respectively (Figures 2 and 3). Low biases were observed, namely 0.03 ± 0.39 L/min for CO and −0.08 ± 1.39 mmHg for cSBP. PWV, HR, and brachial pulse pressure were found to be the most correlated features with CO, whereas brachial SBP was plausibly shown to be the significant determinant of cSBP for our model (Figures 4 and 5).

Conclusion
These findings pave the way for better devising central hemodynamics’ predictions. In the future, our ultimate goal is to examine the sensitivity of cardiac parameters estimation (i.e., elastance) to noninvasive peripheral measurements.
RESILIENSI NAFKAH RUMAH TANGGA DI PULAU KECIL (STUDI KASUS DI NEGERI PAPERU PULAU SAPARUA PROPINSI MALUKU)
Authors: Patty Yeanette S , Pattiselanno August E , Kakisina Leunard O 
Published: February 2020

Pendapatan petani di pulau kecil tidak menentu karena aktivitas ekonominya bergantung pada musim, sehingga melakukan aktivitas ganda, baik usaha pertanian maupun luar pertanian. Masalahnya, kajian mengenai bagaimana tingkat resiliensi rumah tangga dalam menghadapi pola nafkah ganda di pulau kecil masih terbatas dilakukan. Penelitian ini bertujuan untuk menganalisis resiliensi nafkah rumahtangga masyarakat pesisir di pulau kecil. Penelitian dilakukan menggunakan pendekatan kualitatif, dengan jumlah informan 58 orang yang dipilih secara sengaja. Hasil penelitian menunjukkan strategi nafkah yang dikembangkan petani di Negeri Paperu dilakukan melalui tiga cara yaitu mengembangkan usahataninya dengan komoditas cengkeh dan pala, nelayan, dan usaha luar pertanian seperti berdagang dan usaha warung dimana sebagian besar rumahtangga memiliki resiliensi yang tergolong tinggi. Hal ini ditunjukkan dengan kemampuan melakukan dinamisasi strategi nafkah, dari kegiatan ekonomi on-farm, ke off-farm, bahkan non-farm.
FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON
Authors: Istarini Attiya , Syafrita Yuliarni , Susanti Restu 
Published: February 2020

<p><strong><em>Background</em></strong><em>: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some factors that influence motor symptoms in Parkinson's disease.</em><strong><em>Methods:</em></strong><em> This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values &lt;0.05 were considered statistically significant.</em><strong><em>Results:</em></strong><em> This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p &lt;0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.</em><strong><em>Conclusions:</em></strong><em> There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.</em></p>
Hubungan Faktor Pendukung Customer Relationship Manajemen dengan Loyalitas Pasien Poli Interna Ratulangi Medical Centre
Authors: Burhanuddin Nurfardiansyah , Suyuti Sartika 
Published: February 2020

Customer Relationship Management bertujuan untuk proses adaptasi antara klinik dengan pelangganya. Jadi klinik manapun sebenarnya bertanggung jawab menjalankan program Customer Relationship Management, setiap devisi, setiap klinik dan setiap petugas pelayanan harus mengetahui tentang program tersebut, tujuan-tujuannya, dan yang paling penting apa peranan mereka dan bagaimana mereka dapat memberikan kontribusi dalam menjalankan program itu. Berdasarkan uraian diatas maka perlu dilakukan penelitian yang bertujuan mengidentifikasi Hubungan Faktor Pendukung Customer Relationship Management (CRM) dengan Loyalitas Pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC) Kota Makassar. Penelitian ini merupakan penelitian kuantitatif menggunakan survey analik dengan rancangan cross sectional study yaitu suatu rancangan penelitian yang mempelajari hubungan antara variabel independen (Petugas pelayanan, Proses pelayanan, Teknologi pelayanan) dengan variabel dependen (Loyalitas pasien). Populasi penelitian ini adalah kunjungan pasien di poli interna Klinik Ratulangi Medical Centre (RMC) Kota Makassar yang menggunakan pelayanan kesehatan tahun 2017, yaitu sebanyak 1296 pasien dengan jumlah sampel 117 pasien. Metode pengumpulan sampel dilakukan dengan cara random sampling. Berdasarkan hasil uji statistik diperoleh masing masing nilai petugas pelayanan p=0,559, proses pelayanan p=0,740, dan teknologi pelayanan p=0,760. Semua variable tidak berhubungan faktor Customer Relationship Management (CRM) dengan loyalitas pasien di poli interna klinik Ratulangi Medical Centre (RMC). Hal ini dapat dilihat dengan keputusan tingkat loyalitas pasien sebagian besar melihat aspek petugas pelayanan yang dimiliki klinik Ratulangi Medical Centre (RMC). Menyangkut petugas pelayanan sebagian besar pasien setuju bahwa petugas mampu memberikan kemampuan, keterampilan, dan keramahan kepada pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Proses pelayanan sebagian besar pasien setuju bahwa proses pelayanan mudah untuk lakukan. Membantu petugas untuk lebih mengenali dan menjalin hubungan dekat dengan pasien. Dimensi proses terbentuk karena identifikasi profil, komunikasi dengan pelanggan, dan penanganan keluhan pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Teknologi pelayanan, beberapa pasien setuju bahwa teknologi pelayanan mudah untuk mendapatkan informasi, membantu mempercepat dan mengoptimalkan faktor manusia dan proses bisnis dalam aktivitas pengelolaan hubungan dengan pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Kesimpulan dari penelitian bahwa tidak terdapat hubungan faktor pendukung Customer Relationship Management (petugas pelayanan, proses pelayanan, dan teknologi pelayanan) dengan loyalitas pasien di poli interna klinik Ratulangi Medical Centre (RMC) Kota Makassar tahun 2018.
Development of the Composition and Technology of New Neuroprotective Drug Tablets Using Fractional Factorial Design
Authors: Terenteva O. A. , Flisyuk E. V. , Ivkin D. Yu. , Narkevich I. A. 
Published: February 2020

Introduction. The creating an effective and safe domestic neuroprotective medicines with a complex of pleiotropic effects realized through specific orphan receptors (SUCNR1, HCA2) of glial cells, is a pressing problem of modern pharmacology and a promising possibility of pharmacotherapy of brain injury and cerebrovascular diseases. Ideally, the medicine should helps restore lost cognitive functions and physical performance after damage to the central nervous system, and its use should improve the quality of life of patients and reduce the risk of complications.Aim. To develop composition and technology of a new medicine tablets with neuroprotective effect, using fractional factorial design of experiment and the Harrington desirability function.Materials and methods. The shape and size of particles, physicochemical (solubility, melting point) and technological properties (bulk density, compressibility factor, fractional composition, hygroscopicity) of the pharmaceutical substance of DEAE derivative were studied according to the methods described in the State Pharmacopoeia of the Russian Federation (14th edition). A three-factor fractional plan based on the 4 × 4 Latin square design for selection a scientifically based composition of solid dosage form was chosen. 16 experiments to test the significance of the factors were carried out. The tablets obtained according to the planning matrix were investigated for disintegration; tablet crush resistance, friability, and hygroscopicity. To optimize the quality of the tablets, the generalized Harrington desirability function was used.Results and discussion. The study of the physicochemical and technological properties of the DEAE derivative substance showed that it is a highly hygroscopic, amorphous, white or pale yellow, odourless powder, prone to the formation of agglomerates. The powder is very easily soluble in water. Taking into account the values of the general desirability function, the best result was shown by sample № 4 consisting of mannitol, calcium stearate, and partially pregelatinized maize starch.Conclusion. The physicochemical and technological properties of the DEAE derivative were studied. The DEAE derivative is a highly hygroscopic substance. Via the method of mathematical planning of the experiment the composition of DEAE derivative tablets was selected and scientifically grounded: DEAE derivative 60 mg, mannitol, partially pregelatinized maize starch, calcium stearate. The average tablet weight is 300 mg. The parameters of pressing tablets were selected.
Um Breve Olhar nas Fotografias do Ano Revolucionário Cubano nos Livros Didáticos de História do PNLD 2018
Authors: Pérola Dantas Barros Maria Luiza 
Published: February 2020

Recebido: 15/10/2019
Aprovado: 27/11/2019
No contexto das comemorações em torno dos 60 anos do ano revolucionário cubano (1959), se faz necessário pensar como que a representação de um fato que, nas palavras de Feitosa (2010) marcaria a história da América Latina no século XX e ainda permanece como referência para os movimentos sociais do século XXI, tem alcançado os estudantes brasileiros. Compreendendo a fotografia a partir de Kossoy (2009), como uma representação a partir do real segundo o olhar e a ideologia de seu autor, e entendendo por representação o proposto por Chartier (1988), no que se refere a este ser um vasto campo que engloba as percepções do social, este artigo tem por objetivo lançar um breve olhar nas fotografias do ano revolucionário cubano, buscando compreender se elas são ou não trabalhadas como fontes nos livros didáticos de História, aprovados pelo Programa Nacional do Livro Didático (PNLD) 2018, a partir da relação de ancoragem da imagem pelo texto proposta por Roland Barthes (1961;1964;1990).
Palavras-chaves: Revolução Cubana. Ano Revolucionário. Fotografias. Ancoragem. Livro Didático de História.
A Inteligência Norte-americana e a Crise dos Mísseis de 1962
Authors: Lima Raquel 
Published: February 2020

Recebido: 15/10/2019
Aprovado: 27/11/2019
O objetivo deste artigo é analisar o papel que a inteligência norte-americana, exercida pela Central Intelligence Agency (CIA), teve na Crise dos Mísseis de 1962, em Cuba. Observaremos como foi o processo de descoberta dos mísseis pela agência, quais seus acertos e falhas, e as consequências destas, e que leitura a CIA teve do cenário que se formou entre os EUA, URSS e Cuba. Assim, nossa problemática está voltada para entendermos como foi sua ação e qual sua importância para a política norte-americana. Metodologicamente este trabalho está pautado em uma revisão historiográfica sobre os acontecimentos em envolveram a CIA e a Crise, que serão analisados através de teorias voltadas para agendas de segurança e defesa.
Palavras-chave: Crise dos Mísseis; CIA; Cuba; Inteligência.