bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of autonomy phase during the Anaesthesia and Critical Care residency: Monocentric University Hospital experience
Authors: Dehaen-Rougelin Claire , grognu alexandre , Besnier Emmanuel , clavier Thomas , Veber Benoit , dureuil Bertrand , Compere Vincent 
Published: December 2019

Abstract
Background: A new French curriculum about anaesthesiology and critical care residency has started in November 2017 involving an autonomy phase supervised by seniors with main objective to prepare for the professional exercise. Since 10 years, Anaesthesia and Critical Care Department of Rouen University Hospital has established a similar process with autonomy practice supervised by senior doctor during the last year of residency. Our 5th year training local program is therefore very closed from the new French anaesthesiology and intensive care residency curriculum. In our hospital, In order to project this supervised autonomy phase, the aim of this study was to assess the opinion of our former residents who benefited from our supervised autonomy phase during their last year of training.Methods: A standardized questionnaire was sent to all the residents trained in Rouen between 2004 and 2016 and who have been involved in supervised autonomy phase. Three areas were studied: the profile of responders, the practical and theoretical training received and the supervised autonomy phase.Results: The response rate was 84.1% (95/113). Theoretical and practical training was rated good or excellent for 93.7% of responders. The supervised autonomy status was noted to be positive by 94.2% of the respondents. The highlighted skills were autonomy, learning the organization of working time and preanaesthesia clinic. A majority (85%) of the residents reported having had little or no difficulty and 97% said that this status facilitated their position as a senior physician. This phase of autonomy should be included systematically in the residency for 93% of them. Conclusions: Supervised autonomy status would enable empowerment under secured supervision conditions. The majority of residents felt that this supervised autonomy phase should be systematically included in our training as proposed now by the new French curriculum.
The Understanding of Research Ethics at Health Sciences Schools in Jordan: A Cross-Sectional Study
Authors: Tarboush Nafez Abu , Alkayed Zaid , Alzoubi Karem H. , Al-Delaimy Wael K. 
Published: December 2019

Abstract
Background: Research ethics is required for high-quality research that positively influences society. There is limited understanding of research ethics in Middle Eastern countries including Jordan. Here, we aim to investigate the level of understanding of research ethics principles among health sciences faculty members in Jordan. Methods: This is a cross sectional study where faculty members from the University of Jordan were surveyed for their knowledge and, attitude of research ethics principles. Obtained responses were tabulated according to gender, academic-rank, and knowledge about research ethics principles. Results: Among the 137 participants of this study, most (96%) were involved in human and animal research, yet, only 2/3 had prior training in research ethics. Moreover, 91% believed that investigators should have training in research ethics and 87% believed that there should be a mandatory postgraduate course on that. The average correct scores for correct understanding of researchers towards research ethics was 62%. Yet, there were some misconceptions about the major ethical principles as only 43% identified them correctly. Additionally, the role of research ethics committees was not well understood by most of the respondents.Conclusions: Although there is acceptable knowledge about research ethics, discrepancies in understanding in research ethics principles seems to exist. There is a large support for further training in responsible conduct of research by faculty in health sciences in Jordan. Thus, such training should be required by universities to address this knowledge gap in order to improve research quality and its impact on society.
Improving isobutanol productivity through adaptive laboratory evolution in Saccharomyces cerevisiae
Authors: Zhang Aili , Su Yide , Li Jingzhi , Zhang Weiwei 
Published: December 2019

Abstract
Background: Isobutanol is an ideal second-generation biofuels due to its lower hygroscopicity, higher energy density and higher-octane value. However, isobutanol is toxic to production organisms. To improve isobutanol productivity, adaptive laboratory evolution method was carried out to improve the tolerance of Saccharomyces cerevisiae toward higher isobutanol and higher glucose concentration.Results: We evolved the laboratory strain of S. cerevisiae W303-1A by using EMS (ethyl methanesulfonate) mutagenesis followed by adaptive laboratory evolution. The evolved strain EMS39 with significant increase in growth rate and viability in media with higher isobutanol and higher glucose concentration was obtained. Then, metabolic engineering of the evolved strain EMS39 as a platform for isobutanol production were carried out. Delta integration method was used to over-express ILV3 gene and 2μ plasmids carrying ILV2, ILV5 and ARO10 were used to over-express ILV2, ILV5 and ARO10 genes in the evolved strain EMS39 and wild type W303-1A. And the resulting strains was designated as strain EMS39V2δV3V5A10 and strain W303-1AV2δV3V5A10, respectively. Our results shown that isobutanol titers of the evolved strain EMS39 increased by 30% compared to the control strain. And isobutanol productivity of strain EMS39V2δV3V5A10 increased by 32.4% compared to strain W303-1AV2δV3V5A10. Whole genome resequencing and analysis of site-directed mutagenesis of the evolved strain EMS39 have identified important mutations. In addition, RNA-Seq-based transcriptomic analysis revealed cellular transcription profile changes resulting from EMS39.Conclusions: With the aim of increase productivity of isobutanol in S. cerevisiae, improving tolerance toward higher isobutanol and higher glucose concentration via EMS mutagenesis followed by adaptive evolutionary engineering was conducted. An evolved strain EMS39 with significant increase in growth rate and viability had been obtained. And metabolic engineering of the evolved strain as a platform for isobutanol production was carried out. Furthermore, analysis of whole genome resequencing and transcriptome sequencing were also carried out.
Finding Success in Clinical Trial Recruitment: A Trial Registry Analysis
Authors: Butler Alex , Li Ziran , Liu Cong , Ta Casey , Yuan Chi , Chen Huanyao , Levin Bruce , Hripcsak George , Weng Chunhua 
Published: December 2019

Abstract
Background : Randomized clinical trials are the gold-standard for generating high-quality medical evidence, but patient recruitment remains one of the most important barriers to their success despite significant administrative effort and money being spent to address this problem. While previous studies have highlighted key trial design characteristics, such as trial phase, trial sponsor, and high target accrual, as important factors in why some trials fail to recruit enough patients, these studies have been limited in the number of trials analyzed and in the scope of trial characteristics considered. This work aims to thoroughly assess the association of different trial characteristics on patient enrollment in terms of recruitment rate and early termination rate on a larger scale than has been accomplished previously. Methods : This trial registration analysis collected recruitment information on clinical trials registered in ClinicalTrials.gov as well as trial characteristics from multiple additional databases (Clinical Trials Transformation Initiative, COHD.io, automatically parsed eligibility criteria). Descriptive statistics were calculated and the primary outcomes were associations of individual trial characteristics with patient recruitment rate and likelihood of early termination due to failed patient recruitment as well as variable selection using Group LASSO. Results : The trial characteristics with the strongest significant associations to patient recruitment included design variables (e.g. intervention model, allocation status, number of locations, phase, etc. ), sponsor experience (e.g. sponsor class, number of previous trials terminated due to recruitment issues, ratio of terminated trials to completed trials, etc. ), eligibility criteria (e.g. number of inclusion criteria, number of exclusion criteria), and trial competition (e.g. overlapping eligibility criteria, similar trials within 100 miles, etc. ). Different disease categories also showed different recruitment efficacy. Conclusions : When designing clinical trials, special attention should be paid to design variables, sponsor trial experience, eligibility criteria, and trial competition to balance the likelihood of successful recruitment against evidence strength. Further research is needed to identify causal variables and improve the predictive power of patient recruitment rates to increase the breadth of this analysis.
The effect of a pre- and post- operative exercise programme versus standard care on physical fitness of patients with oesophageal and gastric cancer undergoing neoadjuvant treatment prior to surgery (The PERIOP-OG Trial): Study protocol for a randomised controlled trial.
Authors: Tully Roisin , Loughney Lisa , Bolger Jarlath C , Sorensen Jan , Mcanena Oliver J , Collins Chris G , Carroll Paul A , Arumugasamy Mayilone , Murphy Thomas J , Robb William B 
Published: December 2019

Abstract
Background Advances in peri-operative oncological treatment, surgery and peri-operative care have improved survival for patients with oesophagogastric cancers. Neoadjuvant cancer treatment (NCT) reduces physical fitness, which may reduce both compliance and tolerance of NCT as well as compromising post-operative outcomes. This is particularly detrimental in a patient group where malnutrition is common and surgery is demanding. The aim of this trial is to assess the effect on physical fitness and clinical outcomes of a comprehensive exercise training programme in patients undergoing NCT and surgical resection for oesophagogastric malignancies.Methods The PERIOP-OG trial is a pragmatic, multi-centre, randomised controlled trial comparing a programme of peri-operative exercise with standard care in patients with oesophagogastric cancers treated with NCT and surgery. The intervention group undergo a formal exercise training programme and the usual care group receive standard clinical care (no formal exercise advice). The training programme is initiated at cancer diagnosis, continued during NCT, between NCT and surgery, and then resumed again after surgery. All participants undergo assessments at: baseline, post-NCT, pre-surgery and at 4 and 10 weeks after surgery. The primary endpoint is cardiorespiratory fitness measured by demonstration of a 15% difference in 6-minute walk test assessed at the pre-surgery time point. Secondary endpoints include measures of physical health (upper and lower body strength tests), body mass index, activity behavior, psychological and health related quality of life outcomes. Exploratory endpoints include a health economics analysis, assessment of clinical health by post-operative morbidity scores, hospital length of stay, nutritional status, immune and inflammatory markers, and response to NCT. Rates of NCT toxicity, tolerance and compliance will also be assessed.Discussion The PERIOP-OG trial will determine whether, when compared to usual care, exercise training initiated at diagnosis and continued during NCT, prior to surgery and then during recovery, can maintain or improve cardiorespiratory fitness and other physical, psychological and clinical health outcomes. This trial will inform both the prescription of exercise regimes as well as the design of a larger prehabilitation and rehabilitation trial to investigate whether exercise in combination with nutritional and psychological interventions elicit greater benefits.
A RECEPÇÃO DA MUDANÇA DE PARADIGMAS OCORRIDA NA FILOSOFIA DA LINGUAGEM PELO DIREITO BRASILEIRO COMO SUPERAÇÃO DO MODELO DE INTERPRETAÇÃO DE KELSEN
Authors: Hamel Marcio Renan , Favretto Mariane 
Published: December 2019

O presente artigo procura responder a questão da recepção ou não do giro ontológico-linguístico pela hermenêutica jurídica no Brasil. A recepção ocorreria como superação do modelo de interpretação kelseniano assentado no antigo paradigma da filosofia da consciência. As conclusões sustentaram a tese de que a revolução promovida pela filosofia da linguagem não alcançou a hermenêutica jurídica no Brasil, de modo que ainda impera o paradigma da filosofia da consciência, fundamento do modelo positivista. Desta forma, o modelo interpretativo kelseniano permanece sendo praticado no Direito brasileiro. O método de análise é o hermenêutico-fenomenológico, onde a compreensão e a explicação dos conceitos são elementos-chave, aliado a pesquisa bibliográfica das obras de Kelsen, bem como contando com o auxílio de literatura secundária.
Herausgegeben von Bernd Dörflinger, Claudio La Rocca, Robert Louden y Ubirajara Rancan de Azevedo Marques (eds.) (2015). Kant´s Lectures/Kants Vorlesungen. Berlín-Boston: Walter de Gruyter
Authors: Di Sanza Silvia del Luján 
Published: December 2019

El libro Kants Vorlesungen/Kants Lectures reúne un conjunto de trabajos que fueron elaborados a partir de la presentación y discusión de los mismos en el VIII. Kant Kolloquium que tuvo lugar en Marilia, Brasil, entre el 18 al 21 de agosto de 2013.
Tal como lo indica su título, su objeto de estudio está constituido por las Lecciones o clases dictadas por Kant, las que constituyen un testimonio de la actividad pública del filósofo y una fuente fundamental para el estudio de la evolución de su pensamiento, ya que profundizan, complejizan y complementan aspectos de su doctrina, tal como la conocemos a través de sus obras publicadas. Los trabajos se orientan según distintas líneas de investigación: histórica y especulativo-conceptual. El texto brinda abundante material para el estudio del pensamiento de Kant, tanto respecto a las fuentes, como a la discusión con los filósofos de la época y, también, con respecto a la elaboración de su propio pensamiento, que él mismo ha ido efectuando en la medida en que exponía los temas y los autores. Los trabajos están escritos, algunos en inglés y otros en alemán.
El libro nuclea a destacados investigadores de América y Europa y comienza exponiendo los elementos históricos fundamentales para ubicar las Lecciones en el conjunto del pensamiento de Kant.
Visible-Infrared spectroscopy and chemical properties of water in mining area
Authors: Seifi Aliyeh , Hosseinjanizadeh Mahdieh , Ranjbar Hojjatolah , Honarmand Mehdi 
Published: December 2019

Abstract
The present research focuses to investigate the relationship between spectral and chemical characteristics of water samples in Darrehzar mine. In order to reach this aim the chemical characteristics of water were measured through pH, electrical conductivity (EC) and inductively coupled plasma mass spectrometry (ICP-MS) analysis. Furthermore, the visible near infrared (VNIR) and shortwave infrared (SWIR) spectra of water samples were measured by Analytical Spectral Devices (ASD) FieldSpec3 spectroradiometer and the relationships between spectral and chemical characteristics of water samples were calculated. Results of the pH and EC measurements showed that water with high acidity and EC values which indicates presence of acid drainage was located inside the mine. High concentration of copper, sulfur and iron at the samples could be related to copper mineralization and association with acid mine drainage. Results of spectroscopy revealed that second absorption feature (AF2) magnitude correlated significantly with pH (−0.599), EC (0.611) (p &lt; 0.1) and total trace elements plus sulfur (0.822) (p &lt; 0.05). The significant correlation of the AF2 magnitude with concentrations of S (0.854), Pb (0.914), Ni (0.836), Mn (0.834), Co (0.848) and AF3 with concentration of Fe (0.886) confirm that absorption feature magnitude increases by increasing metals concentrations in water.
Synthesis, Docking Study, Cytotoxicity, Antioxidant, and Anti-microbial Activities of Novel 2,4-Disubstituted Thiazoles Based on Phenothiazine
Authors: An Tran Nguyen Minh , Phuong Pham Thai , Quang Nguyen Minh , Son Nguyen Van , Cuong Nguyen Van , Tan Le Van , Tri Mai Dinh , Alam Mahboob , Tat Pham Van 
Published: December 2019

:
A series of novel 1,3-thiazole derivatives (5a-i) with a modified phenothiazine moiety were
synthesized and tested against cancer cell line MCF-7 for their cytotoxicity. Most of them (5a-i) were less
cytotoxic or had no activity against MCF-7 cancer cell line.

Material and Methods:
The IC50 value of compound (4) was 33.84 μM. The compounds (5a-i) were also
evaluated for antimicrobial activities, but no significant activity was observed. The antioxidant activity was
conducted for target compounds (5a-i). The IC50 value of compound (5b) was 0.151mM.

Results:
The total amount of energy, ACE (atomic contact energy), energy of receptor (PDB: 5G5J), and
ligand interaction of structure (4) were found to be 22.448 Kcal.mol-1 , -247.68, and -91.91 Kcal.mol-1,
respectively. The structure (4) is well binded with the receptor because the values of binding energy, steric
energy, and the number of hydrogen bondings are -91.91, 22.448 kcal.mol-1, and 2, respectively. It shows that
structure (4) has good cytotoxicity with MCF-7 in vitro.

Conclusion:
The increasing of docking ability of structures (5a-i) with the receptor is presented in increasing
order as (5f)>(5e)>(5g)>(5a)>(5b)>(5d)>(5c)>(5i)>(5h). The structure bearing substitution as thiosemicarbazone
(4), nitrogen heterocyclic (5f), halogen (5e), and azide (5g) showed good cytotoxicity activity
in vitro.
Investigating the Effect of Cognitive-behavioral Stress Management on Occupational Performance among Women with Breast Cancer
Authors: Shayan Arezoo , Refaei Mansoureh , Jamshidi Farkhondeh 
Published: December 2019

Background:Treatment of breast cancer can be accompanied by long-term consequences affecting women’s participation in many tasks.Objective:This study aimed to assess the effect of cognitive behavioral stress management (CBSM) program on occupational performance of women with breast cancer.Methods:In this randomized clinical trial, conducted between Feb 3 and Oct 26, 2016, 104 women with breast cancer who had referred to Imam Khomeini clinic in Hamadan, and who fulfilled the inclusion criteria (20-60 years old, married, suffering from grade 1-3 breast cancer with a history of recent surgery) were enrolled. They were randomly divided into two groups of 52 using a permuted block size of four. The intervention group took part in four 60-minute sessions of CBSM over four weeks. The study data were collected using a demographic information form and the Canadian Occupational Performance Measure. The statistical analyst was masked to intervention allocation. The data were analyzed using descriptive statistics, paired t-test, and repeated measures ANOVA.Results:A significant difference was observed between the two groups regarding the mean scores of occupational performance (p=0.02) and satisfaction (p=0.005) after the intervention. Each variable was measured at three time points (before the intervention, immediately and 2 weeks after intervention). A significant difference was observed in the two groups’ mean scores of performance (p=0.026) and satisfaction (p=0.01), irrespective of the time of assessment.Conclusion:The CBSM program promoted the occupational performance immediately and two weeks after the intervention in women with breast cancer. This technique can be used as a complementary method alongside medical therapies in oncology centers.
O tempo da comunidade e o tempo do turismo: notas sobre duas festas
Authors: Araújo Emília , Silva Márcia , Ribeiro Rita 
Published: December 2019

Este artigo explora algumas das principais implicações e desafios que o processo crescente de turistificação das festas de caráter religioso e popular pode representar para as comunidades locais, num momento em que se tornam ofertas turísticas potenciais, com exposição crescente nos mais diversos tipos de média. Em Portugal, celebram-se anualmente muitas festas populares que, sendo de caráter religioso, são expressão do entrecruzamento de elementos diversos, ligados tanto ao tempo sagrado, como ao tempo natural e agrícola e ao tempo profano.Tal como acontece com outros tipos de eventos de caráter popular e religioso, as festas são cada vez mais perspetivadas como potenciais “produtos” turísticos que servem para expor a singularidade das comunidades detentoras e atrair a atenção de visitantes. Neste texto, pretende-se discutir a dificuldade teórica e metodológica de pensar separadamente o tempo da comunidade, do tempo do turismo, atendendo ao caráter identitário que a festa adquire. Este exercício é baseado numa exploração de informação recolhida em trabalhos realizados e em curso acerca de duas festividades que passam, cada uma a seu modo, por estes processos na atualidade: a Bugiada e Mouriscada ou S. João de Sobrado e a Semana Santa em Braga.
Successful Moderation in Online Patient Communities: Inductive Case Study
Authors: Skousen Tanner , Safadi Hani , Young Colleen , Karahanna Elena , Safadi Sami , Chebib Fouad 
Published: December 2019

Background
Online patient communities are becoming more prevalent as a resource to help patients take control of their health. However, online patient communities experience challenges that require active moderation.

Objective
This study aimed to identify the challenges of sustaining a thriving online patient community and the moderation practices employed to address the challenges and manage the online patient community successfully.

Methods
An inductive case study of Mayo Clinic Connect was analyzed using the grounded theory methodology. Insights for the analysis were obtained from semistructured interviews with community managers and community members. Secondary data sources, such as community management documents, observational meeting notes, and community postings, were used to validate and triangulate the findings.

Results
We identified four challenges unique to online patient communities. These challenges include passion, nonmedical advice, personal information, and community participation. We identified five categories of practices that community members used to address these challenges and moderate the community successfully. These practices include instructive, semantic, connective, administrative, and policing practices.

Conclusions
Successful moderation in online patient communities requires a multitude of practices to manage the challenges that arise in these communities. Some practices are implemented as preventive measures while other practices are more interventive. Additionally, practices can come from both authority figures and exemplary members.