bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-related changes in the motor planning strategy slow down motor initiation in elderly adults
Authors: Frolov Nikita S. , Pitsik Elena N. , Maksimenko Vladimir A. , Grubov Vadim V. , Kiselev Anton R. , Wang Zhen , Hramov Alexander E. 
Published: May 2020

AbstractAge-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e. the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor planning of fine motor tasks between elderly and young subjects. We demonstrate that aging significantly reduces the speed of motor initiation in the dominant hand task due to the different motor planning strategies employed by elderly and young adults. Based on the results of the whole-scalp electroencephalography (EEG) analysis, we suggest that young adults tend to use the efficient and fast mechanism of motor working memory. In contrast, elderly adults involve a more demanding sensorimotor integration process similar to the non-dominant hand task.
Deviation from mendelian transmission of autosomal SNPs can be used to estimate germline mutations in humans exposed to ionizing radiation
Authors: Leite Filho Hugo Pereira , Pinto Irene Plaza , Oliveira Lorraynne Guimarães , Alves Costa Emília Oliveira , da Cruz Alex Silva , de Melo e Silva Daniela , da Silva Claudio Carlos , Caetano Alexandre Rodrigues , da Cruz Aparecido Divino 
Published: May 2020

AbstractWe aimed to estimate the rate of germline mutations in the offspring of individuals accidentally exposed to Cesium-137 ionizing radiation. Performed analysis considered two distinct groups: a group males and females accidentally exposed to low doses of ionizing radiation from Cs137, the case group, and a control group of non-exposed participants. The case group included 37 participants (11 couples and 15 children born after the accident). The dose absorbed by exposed participants ranged from 0.2 to 0.5 Gray. The control group included 15 families from the state of Goiás, with no history of radiation exposure. DNA samples from peripheral blood were analyzed with the Affymetrix GeneChip®CytoScanHD™to assessde novoSNP-type mutations. A set of scripts previously developed was used to detectde novomutations by comparing parent and offspring genotypes in each SNP marker. Overall numbers of observed Mendelian deviations were statistically significant between the exposed and control groups. Offspring from the population accidentally exposed to low IR doses showed ∼ 46.5% morede novoMendelian deviations than the control group. Parent-of-origin and type of nucleotide substitution were also inferred. Estimates of age-adjustedde novogermline mutation rates were obtained and correlated to Cs-137 radiation dose exposure to evaluate the usefulness of the rate of Mendelian deviations observed in polymorphic SNPs as a biomarker for exposure. This proved useful in a retrospective estimation of the rate ofde novogermline mutations in a human population accidentally exposed to low doses of radiation from Cs-137. Obtained results suggest that observed burden of germline mutations identified in offspring could potentially be a useful biomarker to estimate levels of parental exposure to ionizing radiation.
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2
Authors: Case James Brett , Rothlauf Paul W. , Chen Rita E. , Liu Zhuoming , Zhao Haiyan , Kim Arthur S. , Bloyet Louis-Marie , Zeng Qiru , Tahan Stephen , Droit Lindsay , Ilagan Ma. Xenia G. , Tartell Michael A. , Amarasinghe Gaya , Henderson Jeffrey P. , Miersch Shane , Ustav Mart , Sidhu Sachdev , Virgin Herbert W. , Wang David , Ding Siyuan , Corti Davide , Theel Elitza S. , Fremont Daved H. , Diamond Michael S. , Whelan Sean P.J. 
Published: May 2020

ABSTRACTAntibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and possibly disrupt epidemic transmission. An anticipated correlate of such countermeasures is the level of neutralizing antibodies against the SARS-CoV-2 spike protein, yet there is no consensus as to which assay should be used for such measurements. Using an infectious molecular clone of vesicular stomatitis virus (VSV) that expresses eGFP as a marker of infection, we replaced the glycoprotein gene (G) with the spike protein of SARS-CoV-2 (VSV-eGFP-SARS-CoV-2) and developed a high-throughput imaging-based neutralization assay at biosafety level 2. We also developed a focus reduction neutralization test with a clinical isolate of SARS-CoV-2 at biosafety level 3. We compared the neutralizing activities of monoclonal and polyclonal antibody preparations, as well as ACE2-Fc soluble decoy protein in both assays and find an exceptionally high degree of concordance. The two assays will help define correlates of protection for antibody-based countermeasures including therapeutic antibodies, immune γ-globulin or plasma preparations, and vaccines against SARS-CoV-2. Replication-competent VSV-eGFP-SARS-CoV-2 provides a rapid assay for testing inhibitors of SARS-CoV-2 mediated entry that can be performed in 7.5 hours under reduced biosafety containment.
Labor migration from Southeast Asia to Taiwan: issues, public responses and future development
Authors: Deng Jian-Bang , Wahyuni Hermin Indah , Yulianto Vissia Ita 
Published: May 2020

PurposeThis paper is mainly focused on labor migration from Southeast Asia to Taiwan, showing a route of south–south mobility and discussing the causes of migrant workers in Taiwan, the issues faced by migrant workers as well as public response to migrant workers.Design/methodology/approachBesides a literate review on the topic of migrant worker researches in Taiwan, the data for this research was also based on qualitative interviews and observations conducted both in the fieldwork in Taiwan and in Indonesia between June and August during the summer of 2018.FindingsThe transnational mobility let many migrants from Southeast Asian countries to Taiwan end up losing their cultural capital and “make money” instead. For these migrants, they have experienced a downward social mobility of class through transnational mobility.Research limitations/implicationsBecause of the chosen research approach, the research results may lack generalizability. More migrant laborers from various origin countries were encouraged to include for further research.Practical implicationsLabor migration cases from Southeast Asia to Taiwan could very well serve as good examples in the carrying out of a reflection on the limit of focusing on social science only inside nation-states in order to push a forward thinking on the transnationalization of social inequality.Originality/valueThis paper calls attention to the close linkage between transnational mobility and social inequality. It showed how the transnationalization of social inequality could get new faces through the new waves of labor migration.
Competitive productivity and the challenge of metastasis under rising societal complexity
Authors: Redding Gordon 
Published: May 2020

PurposeThe purpose of this paper is to locate the concept of competitive productivity (CP) within a general theory of societal progress and include new thinking on the challenge of obstacles to be met at certain stages.Design/methodology/approachThe approach is to review the key literature dealing with economic growth and rising societal achievement and to refine out concepts that offer understanding of the dynamics commonly involved, taking illustrative examples from different societies and seeking overall common denominators that appear within the historical processes.FindingsNew understandings of societal progress, using complex adaptive systems theory applied to cities and industrial districts, indicate that two forces are at work to release new positive forms of energy into society. Economies of scale work via the laws of fractal geometry to yield sublinear growth of energy. More intense social interaction works within the core of the society in a different way to yield superlinear growth. These two forms of energy release can feed off each other beneficially in conditions where, as with CP, the forces of competition can work with forces driving efficiency, in conditions where societal order can be supported by appropriate cultural norms.Research limitations/implicationsA wide literature across several disciplines is brought to bear on the very complex question. Some of the theories are new but very well anchored. It is consequently possible to suggest a pattern of multi-determinants able to match the reality and to foster nuanced comprehensive analysis.Practical implicationsImpacts on policy of foreign direct investment and joint venture management.Social implicationsEmphasis on the roles of societal virtues in establishing the cooperativeness needed for CP.Originality/valueFew studies bring together so many disciplinary perspectives into a complete argument.
General contractors’ experience using off-site structural framing systems
Authors: Killingsworth John , Mehany Mohammed Hashem , Ladhari Hana 
Published: May 2020

Purpose
This paper aims to examine general contractors’ experiences of using off-site manufactured structural framing systems. This engaged a single-case study using a qualitative methodology to identify expected benefits, actual benefits and challenges of such systems.

Design/methodology/approach
A single-case study approach evaluated general contractors’ experience of using a manufactured structural framing system. Qualitative data were collated and analyzed from industry domain experts to determine commonalities and thematic thinking.

Findings
The study revealed that the reasons behind considering off-site building systems were: accelerating the project schedule, overcoming site constraints and having a better end-product. The top expected benefits were: saving time (schedule), saving cost and improving quality. The top actual observed benefits were: saving erection time, reducing waste generation, reducing project costs, reducing safety risks and improving construction site logistics. The main challenges encountered were: unfamiliarity of different project parties with the off-site framing system, difficulty with reducing the overall project schedule, heavy site logistics and complicated off-site system design and standards requirements. The findings include solutions to overcome the challenges associated with using a manufactured structural system.

Research limitations/implications
This paper was a case study and therefore inherently limited in its generalizability. The study was conducted with general contractors in the mountain-west region of the USA. However, the implications of the study may have a broad application, as contractors across the globe seek to find similar solutions to using off-site or manufactured construction methods.

Practical implications
Construction labor shortages around the world are forcing the construction industry to find creative solutions to meet the demand for their services. Manufactured or off-site construction methods provide a possible solution to that labor shortage. However, builders need to be aware of the immediate challenges and actual benefits of using a manufactured structural framing system.

Social implications
Manufactured structural framing systems have the potential to impact lean and sustainable practices in construction. Reduced waste, reduced on-site man-power requirements, reduced construction schedules and reduced injuries each improve the lives of construction workers and the communities around these buildings.

Originality/value
An extensive literature review was performed to guide the design of this case study. Much has been written about off-site construction practices, but there is a significant research gap on the topic of structural framing systems. This study contributes to expanding the knowledge of off-site construction and specifically helps researchers and practitioners understand the challenges and benefits of this systematic approach to construction.
Design of efficient multilayer RAM cell in QCA framework
Authors: Singh Rupali , Sharma Devendra Kumar 
Published: May 2020

Purpose
Quantum-dot cellular automata (QCA) is a promising technology, which seems to be the prospective substitute for complementary metal-oxide semiconductor (CMOS). It is a high speed, high density and low power paradigm producing efficient circuits. These days, most of the smart devices used for computing, make use of random access memory (RAM). To enhance the performance of a RAM cell, researchers are putting effort to minimize its area and access time. Multilayer structures in QCA framework are area efficient, fast and immune to the random interference. Unlike CMOS, QCA multilayer architectures can be designed using active components on different layers. Thus, using multilayer topology in the design of a RAM cell, which is not yet reported in the literature can improve the performance of RAM and hence, the computing device. This paper aims to present the modular design of RAM cell with multilayer structures in the QCA framework. The fundamental modules such as XOR gate, 2:1 multiplexer and D latch are proposed here using multilayer formations with the goal of designing a RAM cell with the provision of read, write, set and reset control.

Design/methodology/approach
All the modules used to design a RAM cell are designed using multilayer approach in QCA framework.

Findings
The proposed multilayer RAM cell is optimized and has shown an improvement of 20% in cell count, 30% in area, 25% in area latency product and 48.8% in cost function over the other efficient RAM designs with set/reset ability reported earlier. The proposed RAM cell is further analyzed for the fault tolerance and power dissipation.

Research limitations/implications
Due to the multilayer structure, the complexity of the circuit enhances which can be eliminated using simple architectures.

Originality/value
The performance metrics and results obtained establish that the multilayer approach can be implemented in the QCA circuit to produce area efficient and optimized sequential circuits such as a latch, flip flop and memory cells.
Improving predictive power through deep learning analysis of K-12 online student behaviors and discussion board content
Authors: Hung Jui-Long , Rice Kerry , Kepka Jennifer , Yang Juan 
Published: May 2020

Purpose
For studies in educational data mining or learning Analytics, the prediction of student’s performance or early warning is one of the most popular research topics. However, research gaps indicate a paucity of research using machine learning and deep learning (DL) models in predictive analytics that include both behaviors and text analysis.

Design/methodology/approach
This study combined behavioral data and discussion board content to construct early warning models with machine learning and DL algorithms. In total, 680 course sections, 12,869 students and 14,951,368 logs were collected from a K-12 virtual school in the USA. Three rounds of experiments were conducted to demonstrate the effectiveness of the proposed approach.

Findings
The DL model performed better than machine learning models and was able to capture 51% of at-risk students in the eighth week with 86.8% overall accuracy. The combination of behavioral and textual data further improved the model’s performance in both recall and accuracy rates. The total word count is a more general indicator than the textual content feature. Successful students showed more words in analytic, and at-risk students showed more words in authentic when text was imported into a linguistic function word analysis tool. The balanced threshold was 0.315, which can capture up to 59% of at-risk students.

Originality/value
The results of this exploratory study indicate that the use of student behaviors and text in a DL approach may improve the predictive power of identifying at-risk learners early enough in the learning process to allow for interventions that can change the course of their trajectory.
Educational data mining: a systematic review of research and emerging trends
Authors: Du Xu , Yang Juan , Hung Jui-Long , Shelton Brett 
Published: May 2020

Purpose
Educational data mining (EDM) and learning analytics, which are highly related subjects but have different definitions and focuses, have enabled instructors to obtain a holistic view of student progress and trigger corresponding decision-making. Furthermore, the automation part of EDM is closer to the concept of artificial intelligence. Due to the wide applications of artificial intelligence in assorted fields, the authors are curious about the state-of-art of related applications in Education.

Design/methodology/approach
This study focused on systematically reviewing 1,219 EDM studies that were searched from five digital databases based on a strict search procedure. Although 33 reviews were attempted to synthesize research literature, several research gaps were identified. A comprehensive and systematic review report is needed to show us: what research trends can be revealed and what major research topics and open issues are existed in EDM research.

Findings
Results show that the EDM research has moved toward the early majority stage; EDM publications are mainly contributed by “actual analysis” category; machine learning or even deep learning algorithms have been widely adopted, but collecting actual larger data sets for EDM research is rare, especially in K-12. Four major research topics, including prediction of performance, decision support for teachers and learners, detection of behaviors and learner modeling and comparison or optimization of algorithms, have been identified. Some open issues and future research directions in EDM field are also put forward.

Research limitations/implications
Limitations for this search method include the likelihood of missing EDM research that was not captured through these portals.

Originality/value
This systematic review has not only reported the research trends of EDM but also discussed open issues to direct future research. Finally, it is concluded that the state-of-art of EDM research is far from the ideal of artificial intelligence and the automatic support part for teaching and learning in EDM may need improvement in the future work.
Effects of CEO humility and relationship conflict on entrepreneurial performance
Authors: Li Yi , Wei Feng , Chen Siyue , Yan Yushan 
Published: May 2020

PurposeFirst, this paper aims to explore how CEO humility and relationship conflict in entrepreneurial teams affect the firm-level performance of new ventures. Second, it investigates the moderating effect of CEO political skills on the indirect association between CEO humility and entrepreneurial performance through relationship conflict in entrepreneurial teams.Design/methodology/approachA questionnaire survey was administered to CEOs and their entrepreneurial team members in 171 start-ups in Shanghai, China. The data obtained from the survey were subjected to multiple regression analysis using the SPSS PROCESS macro and confirmatory factor analysis using Mplus.FindingsThe findings are as follows. First, CEO humility can reduce relationship conflict in entrepreneurial teams. Second, CEO political skills moderate the link between CEO humility and relationship conflict in entrepreneurial teams. The weaker the CEO political skills, the stronger the effect of CEO humility on relationship conflict, and the stronger the CEO political skills, the weaker the effect of CEO humility on relationship conflict. Third, relationship conflict in entrepreneurial teams is negatively related to entrepreneurial performance. Finally, CEO political skills moderate the mediating effect of entrepreneurial team relationship conflict on the CEO humility – entrepreneurial performance link.Practical implicationsThe findings of this study offer guidance for entrepreneurs seeking to improve firm performance. The findings suggest that entrepreneurs should adopt a humble leadership style that cultivates their strengths and minimizes their weaknesses. To improve the centripetal force and cohesion of the entrepreneurial team, they should focus on the team, affirm the contribution of subordinates and accept subordinates’ advice.Originality/valueThe study reveals that CEO humility has a positive effect on entrepreneurial performance, which enriches research on the effectiveness of humble leadership at the firm level. From the perspective of team relationship conflict, the study also explores the mechanism underlying the effect of CEO humility on entrepreneurial performance, opening the “black box” of CEO humility and entrepreneurial effectiveness. In addition, the study reveals the boundary conditions of the influence of CEO humility, enriching the theoretical literature on humble leadership, political skills and resource conservation.
Understanding motives for attending charity sport events in Thailand
Authors: Meeprom Supawat , Dansiri Warapon 
Published: May 2020

Purpose
This study aims to examine the effects of motives for attending charity sport events on perceptions of self-congruity and charity sport event identification. It also examined the mediating role of self-congruity on the relationships between motives for attending charity sport events and charity sport event identification.

Design/methodology/approach
Data were collected through an online self-administered survey of 330 participants who had attended charity sport events in Thailand. A series of multiple regressions and the PROCESS macro method were used for analysing direct and indirect effects.

Findings
The results clearly indicated that physical and charitable motives had a significant impact on event identification. While physical, social and charitable motives had an impact on self-congruity, self-congruity had a greater impact on event identification. The role of self-congruity, meanwhile, mediated the relationship between physical, social, enjoyment and charitable motives and the event identification.

Research limitations/implications
The results of this study contribute to the extension of the body of knowledge, especially in regard to special events and charitable foundations where the proposed relationships have yet to be studied.

Originality/value
Using the social identity theory as a theoretical background, the study adds to the comprehensive understanding of social and psychological motives to build an identity and enhance a strong sense of identification and belonging to a charity sport event.