bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of 8-state protein secondary structures by 1D-Inception and BD-LSTM
Authors: Ratul Aminur Rab , Turcotte Marcel , Mozaffari M. Hamed , Lee WonSook 
Published: December 2019

AbstractProtein secondary structure is crucial to create an information bridge between the primary structure and the tertiary (3D) structure. Precise prediction of 8-state protein secondary structure (PSS) significantly utilized in the structural and functional analysis of proteins in bioinformatics. In this recent period, deep learning techniques have been applied in this research area and raise the Q8 accuracy remarkably. Nevertheless, from a theoretical standpoint, there still lots of room for improvement, specifically in 8-state (Q8) protein secondary structure prediction. In this paper, we presented two deep learning architecture, namely 1D-Inception and BD-LSTM, to improve the performance of 8-classes PSS prediction. The input of these two architectures is a carefully constructed feature matrix from the sequence features and profile features of the proteins. Firstly, 1D-Inception is a Deep convolutional neural network-based approach that was inspired by the InceptionV3 model and containing three inception modules. Secondly, BD-LSTM is a recurrent neural network model which including bidirectional LSTM layers. Our proposed 1D-Inception method achieved 76.65%, 71.18%, 76.86%, and 74.07% Q8 accuracy respectively on benchmark CullPdb6133, CB513, CASP10, and CASP11 datasets. Moreover, BD-LSTM acquired 74.71%, 69.49%, 74.07%, and 72.37% state-8 accuracy after evaluated on CullPdb6133, CB513, CASP10, and CASP11 datasets, respectively. Both these architectures enable the efficient processing of local and global interdependencies between amino acids to make an accurate prediction of each class is very beneficial in the deep neural network. To the best of our knowledge, experiment results of the 1D-Inception model demonstrate that it outperformed all the state-of-art methods on the benchmark CullPdb6133, CB513, and CASP10 datasets.
The dengue virus non-structural protein 1 (NS1) use the scavenger receptor B1 as cell receptor in human hepatic and mosquito cells
Authors: Alcalá Ana C. , Maravillas José L. , Meza David , Ramirez Octavio T. , Ludert Juan E. , Palomares Laura A. 
Published: December 2019

AbstractDengue is the most common virus disease transmitted to humans by mosquitoes. The dengue virus NS1 is a multifunctional protein that form part of replication complexes. In addition, NS1 is also secreted, as a hexamer, to the extracellular milieu. Circulating NS1 has been associated with dengue pathogenesis by several different mechanisms. Cell binding and internalization of soluble NS1 result in the disruption of tight junctions and in down regulation of the innate immune response. In this work, we report that the HDL scavenger receptor B1 (SRB1) in human hepatic cells, and a scavenger receptor B1-like in mosquito C6/36 cells act as cell surface binding receptor for dengue virus NS1. The presence of the SRB1 on the plasma membrane of C6/36 cells, as well as in Huh-7 cells, was demonstrated by confocal microcopy. Internalization of NS1 can be efficiently blocked by anti-SRB1 antibodies and previous incubation of the cells with HDL significantly reduces NS1 internalization. In addition, the transient expression of SRB1 in Vero cells, which lack the receptor, renders these cells susceptible to NS1 entry. Direct interaction between soluble NS1 and the SRB1 in Huh7 and C6/36 cells was demonstrated in vivo by proximity ligation assays an in vitro by surface plasmon resonance. Finally, data is presented indicating that the SRB1 also act as cell receptor for zika virus NS1. These results demonstrate that dengue virus NS1, abona fidelipoprotein, usurps the HDL receptor for cell entry and offers explanations for the altered serum lipoprotein homeostasis observed in dengue patients.
Bacterial Major Vault Protein homologs shed new light on origins of the enigmatic organelle
Authors: Sokolskyi Tymofii H. 
Published: December 2019

AbstractVaults are large cone-shaped and highly conservative ribonucleoprotein complexes present in the cells of most major eukaryote clades. However, despite their wide distribution, their functions and evolutionary dynamics still remain enigmatic. Several minor functions in modulating signaling cascades and multidrug resistance phenotypes were previously discovered for eukaryotic vaults, yet nothing is known about bacterial homologs of the major vault protein (MVP), a protein that comprises the entirety of vault external surface. Using gene and protein BLAST searches in NCBI and UniProt databases we identified a number of bacterial species in prokaryotic orders Myxococcales, Cytophagales and Oscillatoriales with >50% identity to eukaryotic MVP sequences. Interestingly, all of these species are characterized by one common feature – gliding type of motility. Secondary structures of the identified proteins were predicted using RAPTORX web service and aligned via jFATCAT-flexible algorithm in the RCSB PDB Java Structure Alignment tool to elucidate structural identity. Coiled coil domain at the MVP C-terminus of all studied bacterial species resembled TolA protein ofEscherichia coliby both structure and sequence. We also showed that MVP sequences from chemotrophic bacteria Myxococcales and Cytophagales contain a domain homologous to eukaryotic band-7 domain, unlike cyanobacterial and eukaryotic major vault proteins. As expected, maximum-likelihood phylogenetic trees for MVP sequences separate studied taxa into two clades – first clade contains Oscillatoriales (Cyanobacteria) and Eukaryotes and the second one contains chemotrophic bacteria. In addition, binding prediction via RAPTORX showed great multiplicity GMP and CMP nucleoside monophosphate binding pockets in Myxococcales and Cytophagales MVP, unlike eukaryotic and cyanobacterial proteins which had much lower affinity to these substrates.Due to high similarity of eukaryotic and cyanobacterial MVP sequences and a pattern of its phylogenetic distribution, we can speculate that the most likely scenario for vault appearance in eukaryotes is horizontal gene transfer from cyanobacteria. Presence of GMP and CMP binding pockets in MVP could also point to a function in depleting cytosolic nucleotide concentration which would be beneficial, for instance, during a viral infection. Further research is necessary to uncover potential functions of this enigmatic protein in bacteria and to determine its evolutionary patterns. In addition, a correlation between MVP presence and gliding motility in bacteria could also lead to elucidating selective pressures on the early evolution of this protein.
How can trading stamp promotions entice customers?
Authors: Teng Weichen 
Published: December 2019

PurposeAlthough trading stamps were popular in the USA and are still popular in some countries, few studies have investigated why customers are willing to participate in the promotional campaign despite the inconvenience of accumulating and storing stamps. The purpose of this paper is to examine the factors influencing customer participation in trading stamp campaigns.Design/methodology/approachThrough an extensive literature review, a research model was proposed and its validity evaluated through structural equation modeling. An empirical investigation using a questionnaire survey was conducted among Taiwanese consumers.FindingsThe functional value of premiums and the enjoyment value of a campaign will directly entice a customer to participate, whereas a customer’s purchase intention will be enhanced due to the functional and emotional values of the premiums, social influence of the campaign and motivation to help others obtain premiums through gift-giving. However, the perceived effort to accumulate stamps will inhibit a customer from participating.Research limitations/implicationsThe possibility of sampling bias may limit the applicability of the findings.Practical implicationsEffective trading stamp campaigns can be implemented by the careful design of premiums to emphasize their functional and emotional values and by emphasizing enjoyment and social values of the campaign.Originality/valueThis study aims to pioneer the application of the consumption value model in discussing trading stamp campaigns to fill the gap in marketing research. Another goal is to help retailers design successful campaigns.
Financial conflict resolution model in BOT contracts using bargaining game theory
Authors: Bayat Morteza , Khanzadi Mostafa , Nasirzadeh Farnad , Chavoshian Ali 
Published: December 2019

Purpose
This study aims to determine the optimal value of concession period length in combination with capital structure in build–operate–transfer (BOT) contracts, based on direct negotiation procurement and considering the conflicting financial interests of different parties involved in the project.

Design/methodology/approach
The financial model of a BOT project is developed considering all the influencing factors. Then, fuzzy set theory is used to take into account the existing risks and uncertainties. Bilateral bargaining game based on alternating-offers protocol is applied between the government and the sponsor to divide project financial benefit considering the lender’s requirements. Finally, concession period and equity level will be determined simultaneously according to the sponsor’s and government’s share of project financial benefit and the lender’s requirements.

Findings
The proposed model is implemented on a real case study, and a fair and efficient agreement on concession period length and capital structure is achieved between the government and the sponsor considering the lender’s requirements. It is revealed that being the first proposer in the bargaining process will affect the concession period length; however, it will not affect the equity level. Moreover, it is shown that considering income tax as a part of government’s financial benefit increases the length of concession period.

Research limitations/implications
The presented model concentrates on direct negotiation procurement in BOT projects where the sponsor and government bargain on dividing financial benefits of project. It is assumed that the product/service price is determined before according to market analysis or users’ affordability. All the revenue of project during concession period is assumed to belong to the sponsor.

Practical implications
The proposed model provides a practical tool to aid BOT participants to reach a fair and efficient agreement on concession period and capital structure. This could prevent failing or prolonging the negotiation and costly renegotiation.

Originality/value
By investigation of previous studies, it is revealed that none of them can determine the optimal value of concession period length and capital structure simultaneously considering the BOT negotiation process and different financial interests of parties involved in the project. The proposed model presents a new approach to determine the financial variables considering the conflicting interests of involved parties. The other novelty aspects of the presented model are as follows: introducing a new approach for calculating the sponsor and the government’s share of project financial benefit that will affect the determination of the concession period length and considering the effect of existing risks and uncertainties on final agreement between the involved parties using fuzzy set theory.
Effectiveness of pull-based print advertising with QR codes
Authors: Trivedi Rohit , Teichert Thorsten , Hardeck Dirk 
Published: December 2019

Purpose
Despite quick response (QR) codes’ prominence, little is known about their embedding in pull-based communications. This study aims to measure QR code effects in print advertising along five different stages of consumer decision making, using advertisement appeals with moderating effects of product category involvement.

Design/methodology/approach
Data were derived from a German market research initiative with 326,212 consumer evaluations for 792 real print advertisements from 26 product categories. Multinomial logit models were used to investigate the effects of QR code presence on consumer reactions.

Findings
QR codes steer purchase intention in a low-involvement product category if used alongside an emotional appeal. Advertisements for high-involvement products benefit if QR codes are combined with an overall informational appeal. QR codes do not enhance the persuasive effects of advertisements’ informational appeals in a low-involvement product category.

Research limitations/implications
The effects of QR codes on consumers’ responses cannot be analysed in isolation but depend on advertisement context. They interact with advertisements’ informational and emotional appeals and product category involvement.

Practical implications
Marketers should not use QR codes indiscriminately but should carefully consider advertisement context. QR codes should be used alongside an emotional appeal if the marketer’s objective is to induce purchase intention in low-involvement settings. Advertisements for high-involvement products need to combine QR codes with an informational appeal.

Originality/value
This study highlights the interplay of effects in print advertisements, which are typically considered push-based when they are combined with QR codes as pull-based communications in the digital marketing area.
Speaking right: HRDs role in mediating good boardroom conversations
Authors: Beech Nick , Gold Jeff , Beech Susan , Auty Tricia 
Published: December 2019

PurposeThis paper aims to explore the impact discourse has on decision making practices within the boardroom and considers how personal proficiency in micro-language use can enhance an individual’s personal efficacy in influencing boardroom decisions. The work uses Habermas’ theory of communicative action to critique board talk, highlighting the need for greater understanding of the power of everyday taken for granted talk in strategy shaping. It illuminates the contribution that human resource development (HRD) professionals can make to the management of such behaviour and minimising dysfunctional behaviour and enabling effective boardroom practices.Design/methodology/approachTraditional governance theory from a business and organisational perspectives are provided before considering the boardroom environment and HRD’s role. The authors undertake ethnographic research supported by conversation analysis to explore how directors use talk-based interpersonal routines to influence boardroom processes and enact collective decision making. The authors provide one extract of directors’ talk to illustrate the process and demonstrate what the data “looks like” and the insights it holds.FindingsThe analysis suggests that the established underlying assumptions and rationale ideologies of corporate governance are misplaced and to understand the workings of corporate governance HRD academics and professionals need to gain deeper insight into the employment of talk within boards. Armed with such insights HRD professionals can become more effective in developing strategies to address dysfunctional leadership and promote good governance practice throughout their organisation.Social implicationsThe work raises a call for HRD to embrace a societal mediation role to help boards to become a catalyst for setting good practice which is strategically aligned throughout the organisation. Such roles require a more dialogical, strategic and critical approach to HRD, and professionals and academics take a more holistic approach to leadership development.Originality/valueThe paper considers the role of the development of HRD interventions that both help individuals to work more effectively within a boardroom environment and support development to shape a boardroom culture that promotes effective governance practice by influencing boardroom practice thereby promoting strong governance and broad social compliance throughout the organisation.
Act your age? Age, intrapreneurial behavior, social capital and performance
Authors: Ben Hador Batia , Klein Galit 
Published: December 2019

PurposeWith increases in life expectancy, age diversity has emerged as a common feature of organizations. The purpose of this paper is to focus on the connection between employee age, intrapreneurial behaviors (i.e. introducing new ventures inside an organization), intra-organizational social capital (SC) and their connection to employee performance.Design/methodology/approachA paper-based survey was distributed among 617 participants from five organizations. Three organizations operate in the industrial industry, while the other two operate in the service field.FindingsThe findings show that intrapreneurial behaviors moderate the positive connection between age and performance. That is, among employees engaged in intrapreneurship, older workers evaluated their performance more highly compared to their younger counterparts. However, among workers who did not participate in intrapreneurship, younger employees evaluated their performances as higher compared to older workers. The authors also found that age was negatively connected to intrapreneurial activities, and this connection was mediated by intra-organizational SC.Originality/valueThe results of this study highlight the contribution of older employees to intrapreneurial activities and organizational performance while pointing to obstacles that may inhibit them from participating in intrapreneurship. The results have both theoretical and practical implications, which can aid HR managers in their attempt to establish a positive age-diversity climate.
Assessing the current state of information security policies in academic organizations
Authors: Weidman Jake , Grossklags Jens 
Published: December 2019

Purpose
Colleges and universities across the USA have seen data breaches and intellectual property theft rise at a heightened rate over the past several years. An integral step in the first line of defense against various forms of attacks are (written) security policies designed to prescribe the construction and function of a technical system, while simultaneously guiding the actions of individuals operating within said system. Unfortunately, policy analysis is an insufficiently discussed topic in many academic communities with very little research being conducted in this space.

Design/methodology/approach
This work aims to assess the current state of information security policies by analyzing in-use policies from 200 universities and colleges in the USA with the goal of identifying important features and general attributes of these documents. The authors accomplish this through a series of analyzes designed to examine the language and construction of these policies.

Findings
To summarize high-level results, the authors found that only 54 per cent of the top 200 universities had publicly accessible information security policies, and the policies that were examined lacked consistency with little shared source material. The authors also found that the tonal makeup of these policies lacked a great deal of emotion, but contained a high amount of tentative or ambiguous language leading toward policies that could be viewed as “unclear.”

Originality/value
This work is an extension of a paper that was presented at ECIS 2018. The authors have added additional analyzes including a cross-policy content and tonal analysis to strengthen the findings and implications of this work for the wider research audience.
Internationalization in higher education: faculty tradeoffs under the social exchange theory
Authors: Romani-Dias Marcello , Carneiro Jorge 
Published: December 2019

Purpose
Although faculty members are regarded as one of the main agents of internationalization in higher education (IHE), research has focused on the upper levels of analysis (e.g. country or educational institution) rather than the individual. The purpose of this paper is to draw from social exchange theory (SET) to examine how the perceptions of costs and expected rewards affect faculty members’ choices of international activities.

Design/methodology/approach
This qualitative study adopted as main methods a review of the literature on IHE and in-depth interviews based on a semi-structured script with an international sample. A sample of 16 researches was selected for interview using the snowball technique of sample selection.

Findings
The authors verified that faculty may seek internationalization in search of job opportunities, greater social approval, greater autonomy and greater security. On the other hand, temporal, monetary, psychological and physical costs discourage faculty members from seeking international insertion. Based on these tradeoffs, our findings suggest that although the basic tenets of SET do apply, the theory does not explicitly address two issues: the fact that costs and rewards are intricately related, and the apparent mismatch between (short-term) costs and (long-term) expected rewards.

Originality/value
This study contributes to the IHE literature by highlighting the crucial role of faculty – that is, the level of analysis of the individual – which has been under-researched and by setting out the reasoning that supports the decision of faculty members to seek (higher) international insertion. Furthermore, this study extends SET as a plausible explanation for the self-internationalization decision by scholars.
Two-phase approach to an integrated reverse logistics network considering different qualities of returned products
Authors: Tarin Nasser , Azar Adel , Ebrahimi Seyyed Abbas 
Published: December 2019

PurposeSome essential issues about modeling of reverse logistics (RL) systems and product recovery networks include consideration of the qualities of the returned products, taking into account uncertainty and integrating the forward and reverse flows. The purpose of this paper is to develop the integrated RL model, which focuses on the control of inventory and production planning problems in a case of uncertainty in demand, quantities and qualities of returns.Design/methodology/approachThe model involves a forward production route, three alternative recovery routes and a disposal route. Various levels of qualities are considered for returned products. A fuzzy mixed integer programming model (FMIP) is developed to provide a solution for the problems of production planning and inventory control. After maximizing the satisfaction degree, different solutions can have the same maximum. Moreover, policies that use all recovery routes and reduce the overall uncertainty have no chance to be chosen. To tackle these problems, a two-phase approach method is applied.FindingsAccording to the results of the numerical example, using different and appropriate recovery options based on the quality of returns can significantly decrease the recovery costs. Similarly, it is shown that the two-phase approach can be an effective and efficient method to reach a satisfactory solution for such problems.Originality/valueIn this study, after maximizing the FMIP model, a two-phase approach ‒ as a novel optimization technique in this research ‒ is employed to achieve a desirable solution.