bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone marrow fibrosis, sequence variant of asxl1, and Sjögren syndrome: A case report
Authors: Santaliestra Marta , Bussaglia Elena , Pratcorona Marta , Monter‐Rovira Anna , Saavedra Silvana , Mozos Anna , Martínez Clara , Nomdedéu Josep F. 
Published: April 2020

AbstractOnly proven pathogenic mutations associated with myeloid neoplasms are key to establish the clonal nature of the bone marrow fibrosis. In cases with genetic variants of uncertain meaning, the clinical picture may be required to rule out secondary causes.
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
Authors: Morgen Michael , Steimbach Raphael R. , Géraldy Magalie , Hellweg Lars , Sehr Peter , Ridinger Johannes , Witt Olaf , Oehme Ina , Herbst‐Gervasoni Corey J. , Osko Jeremy D. , Porter Nicholas J. , Christianson David W. , Gunkel Nikolas , Miller Aubry K. 
Published: April 2020

AbstractWe report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and PCI‐34051 (HDAC8), which we recognized share the same N‐benzylindole core. Hybridization of the two inhibitor structures resulted in dihydroxamic acids with benzyl‐indole and ‐indazole core motifs. These substances exhibit potent activity against HDAC6, HDAC8, and HDAC10, while retaining selectivity over HDAC1, HDAC2, and HDAC3. The best substance inhibited the viability of the SK‐N‐BE(2)C neuroblastoma cell line with an IC50 value similar to a combination treatment with Tubastatin A and PCI‐34051. This compound class establishes a proof of concept for such hybrid molecules and could serve as a starting point for the further development of enhanced HDAC6/8/10 inhibitors.
Sulfonylguanidine Derivatives as Potential Antimelanoma Agents
Authors: Baladi Tom , Hamouda‐Tekaya Nedra , Gonçalves Leticia Christina Pires , Rocchi Stéphane , Ronco Cyril , Benhida Rachid 
Published: April 2020

AbstractSulfonylguanidines are interesting bioactive compounds with a broad range of applications in the treatment of different pathologies. 2‐Aminobenzazole‐based structures are well employed in the development of new anticancer drugs. Two series of novel N‐benzazol‐2‐yl‐N′‐sulfonyl guanidine derivatives were synthesized with the sulfonylguanidine in either an extra‐ or intracyclic frame. They were evaluated for their antiproliferative activity against malignant melanoma tumor cells, thus allowing structure‐activity relationships to be defined. Additionally, NCI‐60 screening was performed for the best analogue to study its efficiency against a panel of other cancer cell lines. The stability profile of this promising compound was then validated. During the synthetic process, an unexpected new deamidination of the sulfonylguanidine towards sulfonamide function was also identified.
Chinese clinical named entity recognition based on stacked neural network
Authors: Zhang Ruoyu , Lu Wenpeng , Wang Shoujin , Peng Xueping , Yu Rui , Gao Yuan 
Published: April 2020

SummaryThe precise named entity recognition (NER) is a key component in Chinese clinical natural language processing. Although clinical NER systems have attracted widespread attention and been studied for decades, the latest NER research usually relies on a shallow text representation with one‐layer neural encoding, which fails to capture deep features and limits its performance improvement. To capture more features and encode the clinical text efficiently, we propose a deep stacked neural network for Chinese clinical NER. The neural network stacks two bidirectional long‐short term memory and gated recurrent unit layers to encode the text twice, followed by a conditional random fields (CRF) layer to recognize named entities in Chinese clinical text. Extensive empirical results on three real‐world datasets demonstrate that the proposed method significantly outperforms six state‐of‐the‐art NER methods. Especially compared with the conventional CRF model, our method has at least 3.75% F1‐score improvement on these public datasets.
Research and application of intrusion detection method based on hierarchical features
Authors: Xie Xin , Jiang Xunyi , Wang Weiru , Wang Bin , Wan Tiancheng , Tang Wenliang , Wang Xianmin 
Published: April 2020

SummaryIntrusion detection is essential to prevent damage to computer systems. However, in recent years, with the development of the network, many complex attack types have appeared, and it has become increasingly difficult to obtain high detection rates and low false alarm rates. In addition, traditional heavily hand‐crafted evaluation datasets for network intrusion detection have not been practical. This article proposes an intrusion detection method based on hierarchical feature learning, which can automatically learn traffic features. The method first learns the byte‐level features of network traffic through one‐dimensional convolutional neural networks and then learns session‐level features using stacked denoising autoencoder. The experiment analyzed the model structure and compared it with other methods. Experiments prove that the method in this article has high accuracy and low false alarm
rate.
Methods for Exerting and Sensing Force in Polymer Materials Using Mechanophores
Authors: Stratigaki Maria , Göstl Robert 
Published: April 2020

AbstractInvited for this month's cover is the group of Dr. Robert Göstl at DWI – Leibniz Institute for Interactive Materials, Germany. The cover shows the mechanochemically induced retro Diels–Alder reaction of the adduct of a π‐extended anthracene and maleimide yielding highly fluorescent anthracenes. This mechanophore motif as well as other force‐responsive molecules are reviewed with regard to their efficient activation and quantification. Read the full text of the Minireview at 10.1002/cplu.201900737.
Noncrop features and heterogeneity mediate overwintering bird diversity in agricultural landscapes of southwest China
Authors: Li Depin , Lee Myung‐Bok , Xiao Wen , Tang Jia , Zhang Zhengwang 
Published: April 2020

AbstractFarmland birds are of conservation concerns around the world. In China, conservation management has focused primarily on natural habitats, whereas little attention has been given to agricultural landscapes. Although agricultural land use is intensive in China, environmental heterogeneity can be highly variable in some regions due to variations in crop and noncrop elements within a landscape. We examined how noncrop heterogeneity, crop heterogeneity, and noncrop features (noncrop vegetation and water body such as open water) influenced species richness and abundance of all birds as well as three functional groups (woodland species, agricultural land species, and agricultural wetland species) in the paddy‐dominated landscapes of Erhai water basin situated in northwest Yunnan, China. Birds, crop, and noncrop vegetation surveys in twenty 1 km × 1 km landscape plots were conducted during the winter season (from 2014 to 2015). The results revealed that bird community compositions were best explained by amounts of noncrop vegetation and compositional heterogeneity of noncrop habitat (Shannon–Wiener index). Both variables also had a positive effect on richness and abundance of woodland species. Richness of agricultural wetland species increased with increasing areas of water bodies within the landscape plot. Richness of total species was also greater in the landscapes characterized by larger areas of water bodies, high proportion of noncrop vegetation, high compositional heterogeneity of noncrop habitat, or small field patches (high crop configurational heterogeneity). Crop compositional heterogeneity did not show significant effects neither on the whole community (all birds) nor on any of the three functional groups considered. These findings suggest that total bird diversity and some functional groups, especially woodland species, would benefit from increases in the proportion of noncrop features such as woody vegetation and water bodies as well as compositional heterogeneity of noncrop features within landscape.
Acute coronary syndromes and acute heart failure: a diagnostic dilemma and high‐risk combination. A statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology
Authors: Harjola Veli‐Pekka , Parissis John , Bauersachs Johann , Brunner‐La Rocca Hans‐Peter , Bueno Hector , Čelutkienė Jelena , Chioncel Ovidiu , Coats Andrew J.S. , Collins Sean P. , de Boer Rudolf A. , Filippatos Gerasimos , Gayat Etienne , Hill Loreena , Laine Mika , Lassus Johan , Lommi Jyri , Masip Josep , Mebazaa Alexandre , Metra Marco , Miró Òscar , Mortara Andrea , Mueller Christian , Mullens Wilfried , Peacock W. Frank , Pentikäinen Markku , Piepoli Massimo F. , Polyzogopoulou Effie , Rudiger Alain , Ruschitzka Frank , Seferovic Petar , Sionis Alessandro , Teerlink John R. , Thum Thomas , Varpula Marjut , Weinstein Jean Marc , Yilmaz Mehmet B. 
Published: April 2020

AbstractAcute coronary syndrome is a precipitant of acute heart failure in a substantial proportion of cases, and the presence of both conditions is associated with a higher risk of short‐term mortality compared to acute coronary syndrome alone. The diagnosis of acute coronary syndrome in the setting of acute heart failure can be challenging. Patients may present with atypical or absent chest pain, electrocardiograms can be confounded by pre‐existing abnormalities, and cardiac biomarkers are frequently elevated in patients with chronic or acute heart failure, independently of acute coronary syndrome. It is important to distinguish transient or limited myocardial injury from primary myocardial infarction due to vascular events in patients presenting with acute heart failure. This paper outlines various clinical scenarios to help differentiate between these conditions and aims to provide clinicians with tools to aid in the recognition of acute coronary syndrome as a cause of acute heart failure. Interpretation of electrocardiogram and biomarker findings, and imaging techniques that may be helpful in the diagnostic work‐up are described. Guidelines recommend an immediate invasive strategy for patients with acute heart failure and acute coronary syndrome, regardless of electrocardiographic or biomarker findings. Pharmacological management of patients with acute coronary syndrome and acute heart failure should follow guidelines for each of these syndromes, with priority given to time‐sensitive therapies for both. Studies conducted specifically in patients with the combination of acute coronary syndrome and acute heart failure are needed to better define the management of these patients.
Maritime cross‐border insolvency in China
Authors: Xu Jingchen 
Published: April 2020

AbstractDue to the high degree of mobility of ships and the special operational structures of shipping companies, it is difficult to harmonise the cross‐border insolvency regime with the maritime law regime governing ships. One of the typical examples is the recent bankruptcy of Hanjin Shipping Co Ltd. Chinese creditors were heavily affected by the bankruptcy of Hanjin. However, Hanjin never filed an application to have its Korean insolvency proceeding recognised in the People's Republic of China (PRC). Nor did it commence any ancillary insolvency application under the Enterprise Bankruptcy Law of the PRC. Taking Hanjin's bankruptcy as an example, this article examines the current statutory regime of cross‐border insolvency in the PRC in detail and analyses the approach adopted by the Chinese courts to resolve the conflicts that arise between the cross‐border insolvency and maritime law regimes.
Scaling up cervical cancer prevention in Western Kenya: Treatment access following a community‐based HPV testing approach
Authors: Mungo Chemtai , Ibrahim Saduma , Bukusi Elizabeth A. , Truong Hong‐Ha M. , Cohen Craig R. , Huchko Megan 
Published: April 2020

AbstractObjectiveTo evaluate access to treatment after community‐based HPV testing as testing within screen‐and‐treat programs has the potential to lower mortality from cervical cancer in low‐resource settings.MethodsA prospective cohort study was conducted in western Kenya in 2018. Women aged 25–65 years underwent HPV self‐testing. HPV‐positive women were referred for cryotherapy. Participant data were obtained from questionnaires during screening and treatment. The proportion successfully accessing treatment and variables associated with successful treatment was determined.ResultsOf the 750 women included, 140 (18.6%) tested positive for HPV. Of them, 135 were notified of their results, of whom 77 (59.2%) sought treatment and 73 (52.1%) received cryotherapy. Women who received treatment had a shorter time from screening to result notification (median 92 days, interquartile range [IQR] 84–104) compared to those who did not (97 days, IQR 89–106; P=0.061). In adjusted analyses, women with a history of cervical cancer screening (odds ratio [OR] 11, 95% confidence interval [CI] 1.42–85.20) and those electing result notification through a home visit (OR 4, 95% CI 1.23–14.17) were significantly more likely to acquire treatment at follow‐up.ConclusionLinkage to treatment after community‐based HPV screening in this population was low, highlighting the need for strategies aimed at strengthening treatment linkage in similar settings.
Using clustering ensemble to identify banking business models
Authors: Marques Bernardo P. , Alves Carlos F. 
Published: April 2020

SummaryThe business models of banks are often seen as the result of a variety of simultaneously determined managerial choices, such as those regarding the types of activities, funding sources, level of diversification, and size. Moreover, owing to the fuzziness of data and the possibility that some banks may combine features of different business models, the use of hard clustering methods has often led to poorly identified business models. In this paper we propose a framework to deal with these challenges based on an ensemble of three unsupervised clustering methods to identify banking business models: fuzzy c‐means (which allows us to handle fuzzy clustering), self‐organizing maps (which yield intuitive visual representations of the clusters), and partitioning around medoids (which circumvents the presence of data outliers). We set up our analysis in the context of the European banking sector, which has seen its regulators increasingly focused on examining the business models of supervised entities in the aftermath of the twin financial crises. In our empirical application, we find evidence of four distinct banking business models and further distinguish between banks with a clearly defined business model (core banks) and others (non‐core banks), as well as banks with a stable business model over time (persistent banks) and others (non‐persistent banks). Our proposed framework performs well under several robustness checks related with the sample, clustering methods, and variables used.
Subterranean life: Behavior, metabolic, and some other adaptations of Astyanax cavefish
Authors: Maldonado Ernesto , Rangel‐Huerta Emma , Rodriguez‐Salazar Elizabeth , Pereida‐Jaramillo Elizabeth , Martínez‐Torres Ataulfo 
Published: April 2020

AbstractThe ability of fishes to adapt to any aquatic environment seems limitless. It is enthralling how new species keep appearing at the deep sea or in subterranean environments. There are close to 230 known species of cavefishes, still today the best‐known cavefish is Astyanax mexicanus, a Characid that has become a model organism, and has been studied and scrutinized since 1936. There are two morphotypes for A. mexicanus, a surface fish and a cavefish. The surface fish lives in central and northeastern Mexico and south of the United States, while the cavefish is endemic to the “Sierra del Abra‐Tanchipa region” in northeast Mexico. The extensive genetic and genomic analysis depicts a complex origin for Astyanax cavefish, with multiple cave invasions and persistent gene flow among cave populations. The surface founder population prevails in the same region where the caves are. In this review, we focus on both morphotype's main morphological and physiological differences, but mainly in recent discoveries about behavioral and metabolic adaptations for subterranean life. These traits may not be as obvious as the troglomorphic characteristics, but are key to understand how Astyanax cavefish thrives in this environment of perpetual darkness.
The eosinophil actin cytoskeleton undergoes rapid rearrangement in response to fluid shear stress
Authors: Son Kiho , Small Mike , Sehmi Roma , Janssen Luke 
Published: April 2020

Abstract
The regulatory processes involved in eosinophil trafficking into tissues are poorly understood; therefore, it is crucial to elucidate these mechanisms to advance the quality of clinical care for patients with eosinophil-mediated diseases. The complex interactions between eosinophil integrin receptors and their corresponding ligands on the post-capillary venules of the bronchial endothelium result in distinct modifications to the cytoskeletal architecture that occur in coordinated, temporally regulated sequences. The current study utilizes real-time confocal microscopy and time-based immunofluorescence staining to further characterize the effects of physiologically relevant fluid shear stress on this novel phenomenon of perfusion-induced calcium response. We found that the mere perfusion of fluid over adhered human eosinophils induced a release of intracellular calcium observed in conjunction with changes in cell morphology (flattening onto the coverslip surface, an increase in surface area, and a loss of circularity), suggesting a previously unknown mechanosensing aspect of eosinophil migration out of the vasculature. Although changes in morphology and degree of calcium release remained consistent across varying perfusion rates, the latency of the response was highly dependent on the degree of shear stresses. Eosinophils were fixed post-perfusion at specific timepoints for immunofluorescence staining to track proteins of interest over time. The distribution of proteins was diffuse throughout the cell prior to perfusion; however, they quickly localized to the periphery of the cell within 5 min. The actin cytoskeleton became markedly built up at the cell edges rapidly after stimulation, forming punctate dots by 4 min, suggesting a pivotal role in directed cell motility.
One‐Step Microfluidic Coating of Phospholipid Microbubbles with Natural Alginate Polymer as a Delivery System for Human Epithelial Lung Adenocarcinoma
Authors: Ilhan‐Ayisigi Esra , Saglam‐Metiner Pelin , Manzi Giuliana , Giannasi Katharine , van Hoeve Wim , Yesil‐Celiktas Ozlem 
Published: April 2020

AbstractIn this study, the neoplastic drug frequently used in the treatment of lung cancer, carboplatin is loaded to microbubbles via a microfluidic platform. In order to increase the drug loading capacity of microbubbles, carboplatin is encapsulated into alginate polymer layer. The phospholipid microbubbles (MBs) are synthesized by MicroSphere Creator, which is connected with T‐junction and micromixer for the treatment with CaCl2 solution to provide gelation of the alginate coated phospholipid microbubbles (AMBs). The carboplatin loaded alginate coated phospholipid microbubbles (CAMBs) result in 12.2 ± 0.21 µm mean size, obtained by mixing with 0.05% CaCl2 using T‐junction. The cytotoxic activities of the synthesized MBs, AMBs, and CAMBs are also investigated with the 3‐(4,5‐Dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) (MTT) and live/dead fluorescent dying assays in the A549 and BEAS‐2B cell lines. The one‐step microfluidic coating of lipid microbubbles with natural alginate polymer appears to be a promising strategy for enhanced drug reservoir properties.
Mutant COMP shapes growth and development of skull and facial structures in mice and humans
Authors: Burger Alexander , Roosenboom Jasmien , Hossain Mohammad , Weinberg Seth M. , Hecht Jacqueline T. , Posey Karen L. 
Published: April 2020

AbstractBackgroundCartilage oligomeric matrix protein (COMP) is an important extracellular matrix protein primarily functioning in the musculoskeletal tissues and especially endochondral bone growth. Mutations in COMP cause the skeletal dysplasia pseudoachondroplasia (PSACH) that is characterized by short limbs and fingers, joint laxity, and abnormalities but a striking lack of skull and facial abnormalities.MethodsThis study examined both mice and humans to determine how mutant‐COMP affects face and skull growth.ResultsMutant COMP (MT‐COMP) mice were phenotypically distinct. Snout length and skull height were diminished in MT‐COMP mouse and the face more closely resembled younger controls. Three‐dimensional facial measurements of PSACH faces showed widely spaced eyes, reduced lower facial height, and decreased nasal protrusion, which correlated with a more juvenile appearing face. Neither MT‐COMP mice nor PSACH individuals show midface hypoplasia usually associated with abnormal endochondral bone growth. MT‐COMP mice do show delayed endochondral and membranous skull ossification that normalizes with age.ConclusionTherefore, mutant‐COMP affects both endochondral and intramembranous bones of the skull resulting in a reduction of the nose and lower facial height in mice and humans, in addition to its well‐defined role in the growth plate chondrocytes.
An asymptotic result for a certain type of delay dynamic equation with biological background
Authors: Koyuncuoğlu Halis Can , Turhan Nezihe , Adıvar Murat 
Published: April 2020

Inspired by Cooke and York's work, we concentrate on the delay dynamic equation

on a nonempty, arbitrary, closed set of real numbers, so‐called a time scale. The utilization of an abstract delay function δ in the above‐given equation relaxes the condition that each individual has a fixed constant life span when it fits a growth process.The main result is obtained by establishing a linkage between the delay dynamic equation and an integral equation. By constructing a phase space for a given initial function, we show the unique solution converges to a predetermined constant.
FaPAO5 regulates Spm/Spd levels as a signaling during strawberry fruit ripening
Authors: Mo Aowei , Xu Tian , Bai Qian , Shen Yuanyue , Gao Fan , Guo Jiaxuan 
Published: April 2020

AbstractPolyamines are important for non‐climacteric fruit ripening according to an analysis of the model plant strawberry. However, the molecular mechanism underlying the polyamine accumulation during ripening has not been fully elucidated. In this study, an examination of our proteome data related to strawberry fruit ripening revealed a putative polyamine oxidase 5, FaPAO5, which was localized in the cytoplasm and nucleus. Additionally, FaPAO5 expression levels as well as the abundance of the encoded protein continually decreased during ripening. Inhibiting FaPAO5 expression by RNAi promoted Spd, Spm, and ABA accumulation while inhibited H2O2 production, which ultimately enhanced ripening as evidenced by the ripening‐related events and corresponding gene expression changes. The opposite effects were observed in FaPAO5‐overexpressing transgenic fruits. Analyses of the binding affinity and enzymatic activity of FaPAO5 with Spm, Spd, and Put uncovered a special role for FaPAO5 in the terminal catabolism of Spm and Spd, with a Kd of 0.21 and 0.29 µM, respectively. Moreover, FaPAO5 expression was inhibited by ABA and promoted by Spd and Spm. Furthermore, the RNA‐seq analysis of RNAi and control fruits via differentially expressed genes (DEGs) indicated the six most enriched pathways among the differentially expressed genes were related to sugar, abscisic acid, ethylene, auxin, gibberellin, and Ca2+. Among four putative PAO genes in the strawberry genome, only FaPAO5 was confirmed to influence fruit ripening. In conclusion, FaPAO5 is a negative regulator of strawberry fruit ripening and modulates Spm/Spd levels as a signaling event, in which ABA plays a central role.