bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Vitreous and retinal lymphoma (PVRL): Risk factor and prognosis
Authors: Cassoux Nathalie 
Published: December 2019

AbstractPrimary Vitreous and retinal lymphoma (PVRL): risk factor and prognosis Pr cassoux PVRL also called primary intra ocular lymphoma (PIOL) is a subset of primary cerebral lymphoma. This lymphoma is part of a heterogeneous group of non‐Hodgkin lymphoma poorly understood and widely incurable. The vast majority of patients are affected by central nervous system diffuse large B cell lymphoma (DLBCL. During the past three decades, there have been consistent reports of an increase in the incidence of NHL worldwide. In the United States, the age‐adjusted incidence rate has almost doubled since the 1970s, from 11.07 per 100 000 in 1975 to 20.20 per 100 000 in 2008 for NHL The etiology of NHL is poorly understood, with the only established risk factors being infection and immune dysregulation. In immunosuppressed patients PVRL is generally associated with EBV infection which is not the case in their immunocompetent counterpart. There is no proofs of the role of environment and exposition to chemical agents had an influence on DLBCL incidence (Interlymph data). Prognosis of PVRL is functional and linked to local progression with a risk of blindness. The poor survival is due to the risk of CNS involvement during evolution. Between 60% and 85% of patients with initially isolated PVRL will develop CNS localization within 29 months of diagnosis PVRL. Until recently, primary central nervous system lymphoma (PCNSL) was associated with a uniformly dismal prognosis. It is now reasonable to anticipate long‐term survival and possibly cure for a significant proportion of patients diagnosed with PCNSL. Poor prognosis is linked to age, performance status and associated comorbidities. A significant number of patients get prolonged survival with intensive chemotherapy plus consolidation.
The Light Sword Lens and its usefulness for presbyopia reduction
Authors: Petelczyc Krzysztof , Miler Michal , Blocki Narcyz , Kolacz Katarzyna , Jaroszewicz Zbigniew , Kakarenko Karol , Kolodziejczyk Andrzej , Rekas Marek 
Published: December 2019

AbstractPurposeTo evaluate the light sword lens ‐ an optical imaging element with extended depth of focus and angularly varying optical power for compensation of presbyopia.MethodsTwo novel light sword lenses were compared with commercially available intraocular lenses with the help of an optical system for intraocular lens testing certified according to the requirements of the International Organization for Standardization. The point spread function, the modulation transfer function for 50 lines/mm and the modulation transfer function area (MTFa) ratio were measured.ResultsThe light sword lenses exhibit a point spread function with a distinct maximum in the whole designed defocus range (0‐3D or 0‐4D). Contrast transfer ratio maintains higher values than 0.2 for defocus at least up to 2.5 D.ConclusionsUnlike the hitherto known solutions, the light sword lens permits to obtain high uniformity of the contrast transfer function and focusing within a range of defocus extending to the value of 3D. Therefore the proposed concept seems to be very promising for a development of presbyopia‐correcting intraocular lenses capable to restore a high quality functional vision substituting lost accommodation range.
Never give up
Authors: Demet Yuksel 
Published: December 2019

AbstractResearch process is the aim of producing new knowledge, deepening and understanding your daily clinical experience. It takes time, persistence and belief in science. The final goal is to contribute to progress on eye diseases and disorders. But It also brings to the researcher a self‐reflection to improve ability to listen, observe, focus, create and excel. Success is dependent on the scientific environment where you work, mentors that you meet and loving people that shares your life. Sharing, asking, patience and creativity are the tools that will guide you in your project. Women face many challenges in that field: it is hard to find a balance between work and family, part‐time work is not always accepted, you enter an uneven playing field, you face an “only” experience. Those challenges can be used to bring an added value to research and medicine: a new way of thinking, diversity in discussions and freedom of thought without being invaded by professional ambition. Beyond the debate of biological difference between man and women, the most important issue is to look to a same problem from a different perspective. Gender diversity is crucial to science.
Metabolomics or proteomics: which way to go?
Authors: Wilmer Beuerman Roger 
Published: December 2019

AbstractIncreasing advances in technology have made it possible to consider the metabolome as an objective. In fact, in some situations it is feasible to carry out proteomics and metabolomics on the same samples. However, there is a caution as a metabolomic study will require much more initial sample than a proteomics study. The same instrument will carry u the two different types of analysis. What do the two methods convey? The metabolome consists of small molecules found within cells that are largely involved in cellular energy production and other basic functions. The time scale for metabolomics is in minutes while the time scale for proteomics is measured in many minutes to hours. So the two approaches complement each other and provide a more complete understanding of the response of cells to an event. For example, when a contact lens is placed over the cornea for the first time, how do the cells of the different layers cope with the change in oxygen levels in the first few minutes and then compensate for the change in conditions over the next hours or days. This is a good example of a situation where both metabolomics and proteomics can provide a more complete understanding of the adjustment of the cornea. The tears are a respository for both the metabolome and proteome.
LINC00511 contributes to glioblastoma tumorigenesis and epithelial‐mesenchymal transition via LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop
Authors: Du Xiaoliu , Tu Yiming , Liu Shuang , Zhao Pengzhan , Bao Zhongyuan , Li Chong , Li Jinhao , Pan Minhong , Ji Jing 
Published: December 2019

AbstractTumour invasion is closely related to the prognosis and recurrence of glioblastoma multiforme and partially attributes to epithelial‐mesenchymal transition. Long intergenic non‐coding RNA 00511 (LINC00511) plays a pivotal role in tumour; however, the role of LINC00511 in GBM, especially in the epigenetic molecular regulation mechanism of EMT, is still unclear. Here, we found that LINC00511 was up‐regulated in GBM tissues and relatively high LINC00511 expression predicted poorer prognosis. Moreover, ectopic LINC00511 enhanced GBM cells proliferation, EMT, migration and invasion, whereas LINC00511 knockdown had the opposite effects. Mechanistically, we confirmed that ZEB1 acted as a transcription factor for LINC00511 in GBM cells. Subsequently, we found that LINC00511 served as a competing endogenous RNA that sponged miR‐524‐5p to indirectly regulate YB1, whereas, up‐regulated YB1 promoted ZEB1 expression, which inversely facilitated LINC00511 expression. Finally, orthotopic xenograft models were performed to further demonstrate the LINC00511 on GBM tumorigenesis. This study demonstrates that a LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop provides potential therapeutic targets for GBM progression.
Outpatient dermatology consultations for oncology patients with acute dermatologic adverse events impact anticancer therapy interruption: a retrospective study
Authors: Barrios D.M. , Phillips G.S. , Freites‐Martinez A. , Hsu M. , Ciccolini K. , Skripnik Lucas A. , Marchetti M.A. , Rossi A.M. , Lee E.H. , Deng L. , Markova A. , Myskowski P.L. , Lacouture M.E. 
Published: December 2019

AbstractBackgroundDermatologic adverse events (dAEs) of anticancer therapies may negatively impact dosing and quality of life. While therapy interruption patterns due to dAEs have been studied in hospitalized cancer patients, similar outcomes in outpatient oncodermatology are lacking.ObjectivesTo analyse the therapy interruption patterns, clinico‐histopathologic characteristics and management outcomes of outpatient dermatology consultations for acute dAEs attributed to the most frequently interrupted class of oncologic agents.MethodsWe performed a retrospective cohort study of all cancer patients who received a same‐day outpatient dermatology consultation for acute dAEs at our institution from 1 January to 30 June 2015. Relevant data were abstracted from electronic medical records, including demographics, oncologic history and explicit recommendations by both the referring clinician and consulting dermatologist on anticancer therapy interruption. Consultations with the most frequently interrupted class of oncologic treatment were characterized according to clinico‐histopathologic features, dermatologic management and clinical outcomes.ResultsThere were 426 same‐day outpatient dermatology consultations (median age 59, 60% female, 30% breast cancer), of which 295 (69%) had systemic anticancer therapy administered within 30 days prior. There was weak inter‐rater agreement between referring clinicians and consulting dermatologists on interruption of anticancer treatment (n = 150, κ = 0.096; 95% CI −0.02 to 0.21). Seventy‐three (25%) consultations involved interruption by the referring clinician, most commonly targeted therapy (24, 33%). Maculopapular rash was commonly observed in 23 consultations with 25 dAEs attributed to targeted agents (48%), and topical corticosteroids were most frequently utilized for management (22, 38%). The majority (83%) of consultations with targeted therapy‐induced dAEs responded to dermatologic treatment and 84% resumed oncologic therapy, although three (19%) at a reduced dose. Rash recurred only in two instances (13%).ConclusionsA high frequency of positive outcomes in the management of targeted therapy‐induced dAEs by outpatient consulting dermatologists and low recurrence of skin toxicity suggests impactful reductions in interruption of anticancer therapy.
Effect of immunosuppressive treatment on biomarkers in adult atopic dermatitis patients
Authors: Roekevisch E. , Szegedi K. , Hack D.P. , Schram M.E. , Res P.C.J.M. , Bos J.D. , Leeflang M.M.G. , Luiten R.M. , Kezic S. , Spuls P.I. , Middelkamp‐Hup M.A. 
Published: December 2019

AbstractBackgroundBiomarkers to objectively measure disease severity and predict therapeutic responses are needed in atopic dermatitis (AD).ObjectivePrimary aim: To identify biomarkers reflecting therapeutic response in patients with AD treated systemically.Secondary aims: (i) To identify a biomarker pattern predicting responsiveness to systemic treatment. (ii) To identify differences in expression of biomarker in filaggrin gene (FLG) mutation carriers vs. non‐FLG mutations carriers.MethodsThirty‐eight severe AD patients treated with methotrexate or azathioprine participated. Serum levels of a proliferation‐inducing ligand, B‐cell activating factor of the TNF family, thymus and activation‐regulated chemokine (chemokine (C‐C motif) ligand 17) (TARC (CCl‐17)), interleukin‐1 receptor antagonist (IL‐1RA), interleukin‐1 bèta, IL‐4, IL‐6, IL‐7, IL‐8, IL‐9, IL‐10, IL‐12, IL‐13, IL‐18, IL‐31, interferon gamma, tumour necrosis factor alpha, vascular endothelial growth factor (VEGF), monokine induced by interferon gamma (chemokine (C‐X‐C motif) ligand 9), interferon gamma‐induced protein 10 (C‐X‐C motif chemokine Ligand 10), monocyte chemoattractant protein‐1 (chemokine (C‐C Motif) ligand 2), macrophage inflammatory protein‐1 beta (chemokine (C‐C motif) ligand 4), regulated on activation, normal T cell expressed and secreted (chemokine (C‐C motif) ligand 5), Cutaneous T‐cell‐attracting chemokine (chemokine (C‐C motif) ligand 27) (CTACK (CCL‐27)), thymic stromal lymphopoietin, IL‐5, interleukin‐1 alpha and granulocyte‐colony stimulating factor were analysed by ELISA and Luminex. The primary outcomes were differences in mean absolute change of SCORing Atopic Dermatitis (SCORAD) between groups after 12 weeks compared with baseline. Responders to treatment were defined by a SCORAD reduction in ≥50%. Buccal mucosa swabs were collected to determine FLG genotype status.ResultsThymus and activation‐regulated chemokine, CTACK, IL‐13 and VEGF showed a significant decrease after treatment with methotrexate or azathioprine. However, no decrease in individual cytokine levels was significantly correlated with a change in any of the outcome parameters. In addition, baseline biomarker levels were not significantly different between responders and non‐responders, and FLG and non‐FLG mutants showed similar biomarker profiles.ConclusionThymus and activation‐regulated chemokine and CTACK were confirmed as potential biomarkers. VEGF and IL‐13 have a potential value as well. Biomarkers could not be used to discriminate at baseline between responders and non‐responders, or FLG genotype status.
Electrophysiological responses of carrot psyllids (Trioza apicalis), in different phases of their life cycle, to volatile carrot and conifer compounds
Authors: Anderbrant Olle , Yuvaraj Jothi Kumar , Høgetveit Lars‐Arne , Nissinen Anne I. , Andersson Martin N. 
Published: December 2019

AbstractCarrot psyllids (Trioza apicalis) pose a constant threat to carrot production in parts of Europe, and treatments with chemical insecticides are common. To be able to develop alternative control tactics, more knowledge about the psyllid's host‐finding behaviour and underlying physiology is needed. Using single‐sensillum recordings from overwintered and non‐overwintered males and females, we found essentially identical responses for the two groups and for both sexes. Using six compounds emanating from carrots or conifers, the psyllids' overwintering plants, and extracts of carrot leaves, five different olfactory sensory neuron classes could be distinguished from our high‐quality recordings, viz. #1 responding strongly and exclusively to terpinene‐4‐ol, #2 responding strongly and most often exclusively to nonanal, #3 responding moderately strongly to terpinolene, #4 responding strongly to (Z)‐3‐hexenal and most often weaker to terpinolene, #5 responding exclusively to carrot extract.
Computer‐aided photo‐identification of a rare stingray, Megatrygon microps
Authors: Keeping Jennifer A. , Reeve‐Arnold Katie E. , Burns Neil M. , Catarina Nilza , Bailey David M. , McNeill Deborah C. 
Published: December 2019

AbstractA protocol for photo‐identification of individual Megatrygon microps has been defined. One hundred and four identification photographs were taken between 2005 and 2019. Spot patterns on the dorsal surface were used to identify individuals. Unique scarring on eight M. microps re‐observed provided an independent confirmation of pattern stability of up to 761 days. Previous studies lacked statistical testing used to validate this photo‐identification approach. I3S photo‐matching software was used to successfully match images, identifying 69 individuals. A photo‐matching software facilitates an open‐source platform for identifying individual M. microps, allowing for better population assessments.
“Sage on the stage or guide on the side”—Undergraduate nursing students’ experiences and expectations of bioscience tutors in a blended learning curriculum: A qualitative study
Authors: Koch Jane , Ramjan Lucie M. , Everett Bronwyn , Maceri Anna , Bell Kate , Salamonson Yenna 
Published: December 2019

AbstractAims and objectivesThis study sought to explore undergraduate nursing students’ perceptions of the role and value of their bioscience tutors in a blended learning curriculum.BackgroundBlended learning approaches typically have reduced face‐to‐face contact with tutors—particularly in bioscience subjects which nursing students have traditionally found difficult, and the move to more web‐based learning resources may compound this difficulty.DesignQualitative descriptive study.MethodsThis qualitative study was conducted with 19 undergraduate nursing students enrolled in bioscience subjects, at a large university in outer metropolitan Sydney, Australia in 2016. Semi‐structured interviews were conducted over the telephone or face‐to‐face. Duration of interviews ranged from 13 to 71 min. Results were thematically analysed. EQUATOR guidelines for qualitative research (COREQ) applied.ResultsTwo main themes with accompanying sub‐themes were identified. The first theme identified the importance of the tutor in bioscience, including their qualities, expertise and contextualisation of learning. The second theme provided insights into students’ perceptions of what they considered good and poor approaches to learning.ConclusionsThis study has clearly shown that while nursing students appreciated the flexibility offered by the online component of a blended learning curriculum, they still wanted an experienced bioscience tutor with clinical experience for their face‐to‐face classes. While the tutor was seen as crucial to providing clarification and context for content that was often challenging, they also played a key role in engaging and motivating students and creating a learning environment where students felt empowered to ask questions and debate issues with their peers. Given the increased use of online learning, further research could determine if the current study findings are also applicable in nonscience areas of study.Relevance to clinical practiceThe importance of students having a sound understanding of the biosciences for safe, effective clinical practice cannot be underestimated.
Threats to patient dignity in clinical care settings: A qualitative comparison of Indonesian nurses and patients
Authors: Asmaningrum Nurfika , Kurniawati Dini , Tsai Yun‐Fang 
Published: December 2019

AbstractAims and objectivesTo explore and compare nurses’ and patients’ viewpoints of disrespectful behaviours that threaten patient dignity during hospitalised care.BackgroundPatient's dignity is an important ethical consideration for nursing care practice. In clinical settings, nurse–patient interactions can generate behaviour considered disrespectful and undignified, often due to a disruptive hospital atmosphere and emotional frustrations of nurses and patients. How behaviours and attitudes threaten patient dignity in Indonesian clinical care settings has not been well studied.DesignQualitative descriptive study.MethodsThis multi‐site study purposively recruited nurses and inpatients from six public hospitals in four districts in Eastern Java, Indonesia. Individual, face‐to‐face semi‐structured interviews were conducted with 35 inpatients and 40 registered nurses from medical and surgical wards. Data from verbatim transcriptions of digital audio recordings were analysed with inductive content analysis. The COREQ checklist for qualitative research was used for reporting this study.ResultsFive categories emerged which described disrespectful behaviours that threaten patient dignity. Three categories were important for both nurses and patients: negligence, impoliteness and dismissal. Descriptions of the behaviours were comparable for both groups. The forth category, inattentiveness, was highlighted by nurses, while the fifth category, discrimination, was highlighted by patients.ConclusionsExamining behaviours considered to be disrespectful in an Indonesian healthcare setting expand on perspectives towards dignity in care. The comparable viewpoints of nurses and patients provide knowledge of how undignified behaviours could be reduced in cross‐cultural healthcare settings. Behaviours perceived as undignified primarily by nurses or patients might result from differences in social roles and responsibilities.Relevance to clinical practiceUnderstanding nurses’ and patients’ perspectives of undignified care is an important step in reducing behaviours that violate patient dignity in clinical practice. Nurses’ commitment to patient‐centred care should include being responsive, compassionate, communicative and attentive, which could ameliorate instances of undignified behaviours.
Couples' Job Insecurity and Relationship Satisfaction in the Netherlands
Authors: Blom Niels , Verbakel Ellen , Kraaykamp Gerbert 
Published: December 2019

AbstractObjectiveThe goal of this study is to estimate the effect of one's own and one's partner's job insecurity on relationship satisfaction, with attention to gender and educational differences in these effects. Second, we test whether the effects of individual job insecurity on individual relationship satisfaction depends on partner job insecurity.BackgroundResearch has established that job insecurity is negatively associated with relationship quality at the individual level, but little is known about how partner's job insecurity shapes individual perceptions of relationship quality. Although one's partner's job insecurity is expected to be negatively associated with relationship quality on average, it may be protective in cases in which individual job insecurity is also high. We expand spillover–crossover and family stress models to develop and test hypotheses about the independent and interactive effects of individual and partner job insecurity on relationship quality and further consider potential gender and educational differences in the independent effects of individual and partner job insecurity on individual perceptions of relationship quality.MethodDutch dyadic longitudinal panel data was used (Dutch Longitudinal Internet Studies for the Social Sciences panels 2008–2015) composed of 11,536 observations of 3,668 individuals. Random and fixed effects models were estimated to study differences between individuals (random effects) and changes over time within individuals (fixed effects).ResultsMen and women were less satisfied with their relationship when they felt more job insecurity, and women were less satisfied when their male partner experienced job insecurity. Men's relationship satisfaction was less strongly related to job insecurity when his partner experienced job insecurity as well. Relationship satisfaction of higher educated men suffered less from job insecurity than that of lower educated men.ConclusionJob insecurity was negatively associated with relationship satisfaction, and this association was dependent on gender and, among men, on partner's job insecurity and educational attainment. A dyadic and moderation perspective is important for understanding the relationship between employment and relationship quality.
An Institutional Theory Approach to the Evolution of the Corporate Social Performance – Corporate Financial Performance Relationship
Authors: Brower Jacob , Dacin Peter A. 
Published: December 2019

AbstractIn the present study, we integrate research from the dynamic institutional theory literature to develop a set of theory‐driven hypotheses regarding how the institutionalization of corporate social performance (CSP) in the organizational field over the period 1991–2008 impacts the CSP‐ corporate financial performance (CFP) relationship for firms in the marketplace. The results of our panel time series and dynamic linear estimation models suggest that early CSP adopters are more likely to experience both greater firm profitability and increased stock market valuation as a result of their higher CSP levels. However, they also tend to incur more firm‐idiosyncratic risk for being ahead of the market’s CSP expectations. We also demonstrate that the significant rise in CSP adoption and activities over time, as CSP has become institutionalized, has resulted in CSP becoming a weaker driver of both firm profitability and stock market valuation.