bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Targeted Search for Fast Radio Bursts from the Sites of Low-redshift Short Gamma-Ray Bursts
Authors: Madison D. R. , Agarwal D. , Aggarwal K. , Young O. , Cromartie H. T. , Lam M. T. , Chatterjee S. , Cordes J. M. , Garver-Daniels N. , Lorimer D. R. , Lynch R. S. , McLaughlin M. A. , Ransom S. M. , Wharton R. S. 
Published: December 2019

Abstract
Some short gamma-ray bursts (SGRBs) are thought to be caused by the mergers of binary neutron stars which may sometimes produce massive neutron star remnants capable of producing extragalactic fast radio bursts (FRBs). We conducted a deep search for FRBs from the sites of six low-redshift SGRBs. We collected high time- and frequency-resolution data from each of the sites for 10 hr using the 2 GHz receiver of the Green Bank Telescope (GBT). Two of the SGRB sites we targeted were visible with the Arecibo Radio Telescope with which we conducted an additional 10 hr of 1.4 GHz observations for each. We searched our data for FRBs using the GPU-optimized dedispersion algorithm heimdall and the machine-learning-based package Fast Extragalactic Transient Candidate Hunter. We did not discover any FRBs, but would have detected any with peak flux densities in excess of 87 mJy at the GBT or 21 mJy at Arecibo with a signal-to-noise ratio of at least 10. The isotropic-equivalent energy of any FRBs emitted from these sites in our bands during our observations must not have exceeded a few times 1038 erg, comparable to some of the lowest energy bursts yet seen from the first known repeating FRB 121102.
Deciphering Residual Emissions: Time-dependent Models for the Nonthermal Interstellar Radiation from the Milky Way
Authors: Porter T. A. , Jóhannesson G. , Moskalenko I. V. 
Published: December 2019

Abstract
Cosmic rays (CRs) in the Galaxy are an important dynamical component of the interstellar medium (ISM) that interact with the other major components (interstellar gas and magnetic and radiation fields) to produce broadband interstellar emissions that span the electromagnetic spectrum. The standard modeling of CR propagation and production of the associated emissions is based on a steady-state assumption, where the CR source spatial density is described using a smoothly varying function of position that does not evolve with time. While this is a convenient approximation, reality is otherwise, where primary CRs are produced in and about highly localized regions, e.g., supernova remnants, which have finite lifetimes. In this paper, we use the latest version of the GALPROP CR propagation code to model time-dependent CR injection and propagation through the ISM from a realistic 3D discretized CR source density distribution, together with full 3D models for the other major ISM components, and make predictions of the associated broadband nonthermal emissions. We compare the predictions for the discretized and equivalent steady-state model, finding that the former predicts novel features in the broadband nonthermal emissions that are absent for the steady-state case. Some of the features predicted by the discretized model may be observable in all-sky observations made by WMAP and Planck, the recently launched eROSITA, the Fermi-LAT, and ground-based observations by HESS, HAWC, and the forthcoming CTA. The nonthermal emissions predicted by the discretized model may also provide explanations of puzzling anomalies in high-energy γ-ray data, such as the Fermi-LAT north/south asymmetry and residuals like the so-called “Fermi bubbles.”
The Interstellar Ribbon: A Unifying Explanation
Authors: Schwadron N. A. , McComas D. J. 
Published: December 2019

Abstract
The Interstellar Boundary Explorer (IBEX) mission discovered the presence of a global structure in energetic neutral atom emissions from the outer heliosphere not predicted by any model—the IBEX “ribbon.” In the search for possible explanations, observations have pointed to a likely source from neutral atoms produced through charge exchange with the outflowing solar wind, the secondary solar wind, which then undergoes charge exchange again beyond the heliopause within the very local interstellar medium. Here we study the plasma structure beyond the heliopause created from a range of secondary neutral atom sources: (1) solar wind atoms, (2) pickup atoms inside the termination shock, and (3) suprathermal atoms from the inner heliosheath, between the termination shock and heliopause. All of these particle sources populate the plasma environment beyond the heliopause. At the high end of the observational energy range of IBEX (3.1–6.0 keV FWHM), the significantly broadened and positionally shifted energetic neutral atom signature of the ribbon suggests plasma structure associated primarily with secondary suprathermal atoms from the inner heliosheath. The population created from this suprathermal population extends well above 6 keV (the top of the IBEX energy range) and provides a source for an extremely broad (>60° in angular) width shifted southward (>10°) in latitude from the direction centered on the local interstellar magnetic field. Thus, the extension of plasma structure to energies above IBEX provides a unified explanation of the ribbon created primarily from secondary solar wind atoms to a broadened and shifted structure (the broad ribbon or belt) created primarily from secondary suprathermal atoms in the heliosheath.
Demography and treatment pattern of patients with head and neck carcinoma presenting to a tertiary care center in India
Authors: Chandarana Mihir N. , Pai Prathamesh S. 
Published: December 2019

Abstract
Aims: This study aims to report on the demographic profile and treatment pattern of head and neck cancer patients and impact of an early treatment decision on treatment. This study also aims to suggest recommendations to improve treatment compliance. Methods: All new patients registered under the head and neck disease management group (DMG) over a period of 3 months at a single center were included. Their demographic details, time to treatment decision, and treatment compliance were determined. The findings were presented to head and neck DMG, and changes were implemented to patient workup with an aim to improve compliance. A reaudit was performed over a period of 3 months and results were compared. Results: Two thousand two hundred and forty patients were included in the analysis. Patients with a treatment decision at 1–4 weeks stood at 28.32%, 63.88%, 80.8%, and 89.87%, respectively. Dropout rate was 26%. About 50% of patients planned for surgical intervention could be treated within the institution. After implementation of changes as recommended by DMG, 2418 patients were analyzed and findings were compared to the previous audit. The dropout rate reduced to 17.57%. The number of patients with a treatment decision at 1–4 weeks were 51.26%, 77.42%, 89.46%, and 94.31%, respectively. Conclusion: Early treatment decision and referral could significantly improve patient dropout and possibly compliance to treatment. Decentralization of cancer care is urgently needed to manage the high numbers of patients presenting to tertiary care centers. Setting up of new regional cancer centers and increasing infrastructure in the existing centers should be the long-term goals.
Third-line therapy in the epidermal growth factor receptor mutation-positive advanced nonsmall-cell lung cancer
Authors: Noronha Vanita , Pande Nikhil , Joshi Amit , Patil Vijay , Trivedi Vaishakhi , Chougule Anuradha , Janu Amit , Mahajan Abhishek , Talreja Vikas , Prabhash Kumar 
Published: December 2019

Abstract
Introduction: The treatment of lung cancer is not defined in the third-line setting and remains an unanswered question. Erlotinib is the only drug approved in the third-line setting. With the introduction of effective first- and second-line therapies, more and more patients warrant an effective third-line therapy. We did a post hoc analysis of our randomized trial for the epidermal growth factor receptor (EGFR)-positive patients who received third-line therapy. Materials and Methods: The present series is of 85 patients who received third-line therapy. Demographic data were collected which included age, performance status, gender, stage, comorbidities, and sites of metastasis. Data were collected for the type of systemic treatment patients received and number of cycles received. Information related to the impact of treatment on the symptoms of patients and the imaging done for response evaluation was collected. Results: Of the 85 patients, there were 13 patients (15%) who achieved a partial response and 34 patients (40%) who had stable disease as best response. There were no complete response and 20 patients (24%) had disease progression at the time of first assessment. The median overall survival (OS) was 8.36 months (95% confidence interval [CI] 6.8–9.8 months) and median progression-free survival was 4.4 months (95% CI 3.3–4.9 months). Grade 3 or 4 toxicities were seen in 42.5% (n = 36) of the total patients. Conclusions: The study provides the patterns and outcomes of systemic treatment in metastatic EGFR-mutated lung adenocarcinoma in patients who have progressed on two or more lines of systemic therapies. This data suggest that third-line systemic therapy may provide meaningful outcomes in these patients.
Nimotuzumab with intensity-modulated radiation therapy in unresectable and platinum-ineligible locally advanced head-and-neck cancer
Authors: Srinivas K. Satish , Sundaram Raja , Divyambika C. V. , Chaudhari Sameer 
Published: December 2019

Abstract
Background: Outcomes with conventional treatment are poor in patients with squamous cell carcinoma of head and neck (SCCHN). Treatment options are further limited for patients ineligible to receive platinum-based chemotherapy due to various factors such as geriatric age, comorbidity, and organ dysfunctions. The present study retrospectively evaluated the effectiveness of nimotuzumab when added to radiation therapy in unresectable, locally advanced SCCHN patients who were ineligible for platinum-based chemotherapy. Materials and Methods: The medical records of 21 patients with unresectable, locally advanced head-and-neck cancer and histologically confirmed squamous cell carcinoma who were ineligible for platinum-based chemotherapy treated with nimotuzumab and intensity-modulated radiation therapy (IMRT) from 2012 to 2017 were retrospectively analyzed. The tumor response rate and overall survival (OS) were analyzed. Patients were assessed for toxicity and adverse events (AEs) as per CTCAE version 4. Statistical analysis was performed using SPSS software. Results: The median number of doses of nimotuzumab received was 6, and median dose of radiotherapy was 60 Gy. The tumor response rate was calculated at 24 weeks after the completion of radiotherapy and was as follows: 76.2% (16) of patients showed complete response, 9.5% (2) of patients showed partial response, 4.8% (1) of patients showed stable disease, and 9.5% (2) of patients showed progression of disease. Median OS was 21 months, whereas 1-year survival rate was 63.7%. No Grade 3 or Grade 4 AEs were observed. Conclusion: Nimotuzumab with IMRT has achieved promising clinical outcomes in unresectable locally advanced SCCHN patients who are ineligible for platinum-based chemotherapy, without accumulation of toxicity.
How cancer of oral cavity affects the family caregivers? – A cross-sectional study in Wardha, India, using the Caregiver Quality of Life Index – Cancer questionnaire
Authors: Goswami Sourav , Gupta Subodh Saran 
Published: December 2019

Abstract
Introduction: Oral cancer is now a major public health problem in India. It does not only affect the patient, but also has a deep psychosocial impact on the family caregivers who are deeply involved with the cancer patient for nursing, timely medication, and consulting the doctor. Studies have found that the caregivers often suffer from depression, anxiety, and fear of losing their near and dear ones. This study aims to capture the psychosocial impact of oral cancer on the family caregivers. Materials and Methods: This was a cross-sectional study carried out in a tertiary care hospital with the primary caregivers of those oral cancer patients who completed their treatment and came for follow-up after 2–3 months of treatment completion. The study participants were recruited till a sample size of 100 was reached. This was adequate to report proportions with an error of 10%. We have used “The Caregiver Quality of Life Index – Cancer” scale to capture the psychosocial impact of oral cancer on primary caregiver of the patient. The study was initiated after obtaining approval from the Institutional Ethics Committee. Informed written consents were obtained from all the study participants before beginning the interviews. Results: Caregivers played an important role in the recovery of the patients. However, the strain of caregiving resulted in increased emotional stress among them. We found 56% of the family caregivers were female and 41% were male. Majority of the caregivers who accompanied the patients to hospital were the spouses. For the caregivers, the mean score for burden of the disease was found to be 60.0 (±20.2), that for disruption was 50.4 (±21.7), and for positive adaptation was 61.4 (±20.7). Conclusion: Caregivers, who are usually invisible to the health-care team, should be recognized and their mental and physical well-being should also be given attention.
Adequacy of surgical margins in oral cancer patients with respect to various types of reconstruction
Authors: Garg Apurva , Mair Manish , Singhavi Hitesh , Bhati Muddasir , Malik Akshat , Mishra Aseem , Nair Deepa , Nair Sudhir , Chaturvedi Pankaj 
Published: December 2019

Abstract
Bacground: Surgical margin is an important prognostic factor for oral cancers (oral squamous cell carcinoma [OSCC]). The correlation of margin with the type of reconstruction has never been studied. Aim: This study aimed to correlate surgical margins with the type of reconstruction. Methods: This was a retrospective study of 410 treatment-naïve OSCC patients. As per the methods of reconstruction, three groups were made when reconstruction was performed using pedicled flap (PF) or local flap, free flap, and primary closure (PC). Statistical Analysis: Chi-square test was used for comparison of margin status as per the method of reconstruction. Mann–Whitney test was used to find the difference between the mean margin width with respect to the type of reconstruction. Results: The overall incidence of close/positive margins was 7.8%. The incidence of close/positive margins was not significantly different in free flap group compared to PF (P = 0.06) or PC (P = 0.835) group. However, there was a significant difference in the incidence of close/positive margins between PC and PF groups (P = 0.021). Whether the reconstruction is performed by the primary surgeon or by a another surgeon, it did not have an impact on adequacy of margins (P = 0.334). Margins were wider when the reconstruction is performed by a different team (P = 0.015) or when reconstruction is performed as compared to PC. Conclusion: Margins are not affected by the type of reconstruction (pedicled vs. free flap) and the team doing reconstruction (same vs. another team). Margins are significantly compromised when a surgeon performs PC himself/herself compared to PF.
Economics of cancer care: A community-based cross-sectional study in Kerala, India
Authors: A. Dinesh T. , Nair Prem , Abhijath V. , Jha Vidya , Aarthy K. 
Published: December 2019

Abstract
Bacground: The estimated incidence of cancer cases in Kerala for 2014 was 31,400 and the mortality associated with it was 13,816. Although the treatment of cancer has shown remarkable advances, it has come with increasing costs. Objective: The objective of this study is to estimate the economic burden of cancer in Vypin Block Panchayat at Ernakulam by analyzing the average total direct and indirect cost of cancer care, socioeconomic status, and cost of cancer care between government and private hospitals. Materials and Methods: A cross-sectional study was conducted for 2 months from March to April 2018. The study was conducted by utilizing an annotated cost questionnaire for completion by patients. Total direct and indirect cost was estimated. Appropriate statistical tests were used. Results: Direct cost for cancer care contributed 75% toward the cost of illness and the remaining was found to be indirect cost. Loss of income (44%) contributed to the largest chunk of indirect cost. The average direct cost for cancer care was found to be Rs. 25,606 and the average indirect cost was Rs. 8772. The average total cost of cancer care was calculated to be Rs. 34,378. Significant statistical variation was found between the cost of cancer care in private and government hospitals. The economic burden of cancer in this Vypin Block Panchayat was found to be Rs. 218,256,977/- Conclusion: The ratio of average income to average cost in this study is skewed which indicates the lack of affordability for cancer care in this population. A very large gap, therefore, exits between income levels and cost of cancer care clearly indicating a vast gap between affordability and cost of treatment, which clearly necessitates the need for a definite policy and state intervention for a mass cancer care program.
Epidemiology and clinical features of retinoblastoma
Authors: Padma Maneya , Kumar Nuthan , Nesargi Prerana S. , Kumari B.S Aruna , Appaji L. , Viswanathan Aarthi 
Published: December 2019

Abstract
Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of children who were diagnosed with RB between the years 2009 and 2014. Aim: RB being a disease of the poor, delayed presentation is common due to lack of awareness. We have analyzed the epidemiological profile of our patients and tried to establish the link between delayed presentation and the presence of high-risk features. High-risk features are associated with higher chance of metastasis and poor rates of vision salvage in RB. Methodology: Data were collected in a retrospective manner from the patient case files retrieved from the Medical Records Department, Kidwai cancer Institute. The data were analyzed using Excel and SPSS software (IBM Corp. released 2016, IBM SPSS statistics software for Mac OS, version 24, IBM Corp., Armonk, NY). Results: A total of 53 patients were diagnosed with RB in the years 2009–2014. There was a male predominance with 1.2:1 incidence. Bilateral RB was present in 21 cases. The mean age of children with bilateral RB was 2.1 years, against 1.5 years in unilateral cases. High-risk features such as optic nerve invasion, choroidal invasion, intracranial extension, and orbital involvement were found in 12, 6, 5, and 5 eyes, respectively. Bone marrow involvement was detected in 5% and lung metastasis in 2%. Intracranial involvement was found in 10.4% and cerebrospinal fluid positivity in 15%. Children with high-risk features had a significant delay in presentation in comparison to those without high-risk features (P = 0.035). Conclusion: Incidence of metastatic disease and delayed presentation is still high in developing countries. Routine eye examination during vaccination visits can ensure early diagnosis and appropriate referral in many of these children.
Differential Diagnosis of Cartilaginous Lesions of Bone
Authors: Suster David , Hung Yin Pun , Nielsen G. Petur 
Published: December 2019

Context.—Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. They can be diagnostically challenging, particularly in small biopsies. In rare cases, benign tumors may undergo malignant transformation.Objective.—To review common cartilaginous tumors, including in patients with multiple hereditary exostosis, Ollier disease, and Maffucci syndrome, and to discuss problems in the interpretation of well-differentiated cartilaginous neoplasms of bone. Additionally, the concept of atypical cartilaginous tumor/chondrosarcoma grade 1 will be discussed and its use clarified.Data Sources.—PubMed (US National Library of Medicine, Bethesda, Maryland) literature review, case review of archival cases at the Massachusetts General Hospital, and personal experience of the authors.Conclusions.—This review has examined primary well-differentiated cartilaginous lesions of bone, including their differential diagnosis and approach to management. Because of the frequent overlap in histologic features, particularly between low-grade chondrosarcoma and enchondroma, evaluation of well-differentiated cartilaginous lesions should be undertaken in conjunction with thorough review of the imaging studies.
Indonesia’s Image from China’s Perspective on South China Sea Dispute (A Preliminary Study on China’s Perception on Indonesia)
Authors: Kartikasari Ardina 
Published: December 2019

This paper discusses the image of Indonesia in the eyes of China on the South China Sea (SCS) dispute. China circulated the map of Nine-dotted lines in 1993 and since then China has behaved ambiguously towards Indonesia as the dotted lines encompasses some part of Indonesia’s North Natuna waters. China insists two countries have overlapping interests over some of Indonesia’s Natuna Exclusive Economic Zone which China claims as it traditional fishing ground. China, however recognizes Indonesia’s sovereignty over the Natuna Islands and has been cautious when dealing with Indonesia on the Natuna issue. This behavior continues until the last three incidents occurred in Natuna waters in 2016. Although there are many studies on the South China Sea dispute and China’s policy towards Indonesia, few if any of them discuss specifically on China’s perspective towards Indonesia. Adopting image theory as an analytical framework, this paper figures Indonesia’s image on the eyes of China, which then shaped China’s perception toward Indonesia on SCS dispute. The main argument in this paper is China captures Indonesia’s image as an ally image. In this image, Indonesia is seen as an actor who can work together, has similar capabilities and cultural dimensions with China.