bluuebunny/crossref_metadata_2025_split huggingface dataset:
POLÍTICA DE SAÚDE NO CÁRCERE FLUMINENSE: IMPACTOS DA PANDEMIA DE COVID-19
Authors: Tavares Natália Lucero Frias , Garrido Rodrigo Grazinoli , Santoro Antonio Eduardo Ramires 
Published: April 2020

O presente trabalho tem por propósito analisar as políticas públicas de saúde para às pessoas presas no Estado do Rio de Janeiro e seus impactos para o enfrentamento da pandemia de coronavírus. O problema que se presente enfrentar é: quais as medidas para mitigar os efeitos da pandemia de coronavírus foram tomadas em relação ao direito à saúde das pessoas presas no Estado do Rio de Janeiro? E secundariamente: no que a falta de uma política pública de saúde no cárcere pode impactar a sociedade no âmbito da pandemia de Covid-19? Para tanto desenvolveu-se uma pesquisa qualitativa, a partir de fontes documentais, sobre as cifras prisionais, sobre o impacto da Covid-19 no mundo e suas possibilidades de enfrentamento, bem como uma análise das medidas que vem sendo adotadas no Brasil e, especialmente, no Estado do Rio de Janeiro.
Patients’ Use of Social Media for Diabetes Self-Care: Systematic Review
Authors: Elnaggar Abdelaziz , Ta Park Van , Lee Sei J , Bender Melinda , Siegmund Lee Anne , Park Linda G 
Published: April 2020

Background
Patient engagement with diabetes self-care is critical to reducing morbidity and mortality. Social media is one form of digital health that is available for diabetes self-care, although its use for peer-to-peer communication has not been systematically described, and its potential to support patient self-care is unclear.

Objective
The primary aim of this systematic review was to describe the use of social media among patients (peer-to-peer) to manage diabetes and cardiovascular disease (CVD). The secondary aim was to assess patients’ clinical outcomes, behavioral outcomes, quality of life, and self-efficacy resulting from peer-to-peer social media use.

Methods
We conducted a literature search in the following databases: PubMed, EMBASE, Web of Science, CINAHL, and PsycINFO (January 2008 through April 2019). The inclusion criteria were quantitative studies that included peer-to-peer use of social media for self-care of diabetes mellitus (with all subtypes) and CVD, including stroke.

Results
After an initial yield of 3066 citations, we selected 91 articles for a full-text review and identified 7 papers that met our inclusion criteria. Of these, 4 studies focused on type 1 diabetes, 1 study included both type 1 and 2 diabetes, and 2 studies included multiple chronic conditions (eg, CVD, diabetes, depression, etc). Our search did not yield any individual studies on CVD alone. Among the selected papers, 2 studies used commercial platforms (Facebook and I Seek You), 3 studies used discussion forums developed specifically for each study, and 2 surveyed patients through different platforms or blogs. There was significant heterogeneity in the study designs, methodologies, and outcomes applied, but all studies showed favorable results on either primary or secondary outcomes. The quality of studies was highly variable.

Conclusions
The future landscape of social media use for patient self-care is promising. However, current use is nascent. Our extensive search yielded only 7 studies, all of which included diabetes, indicating the most interest and demand for peer-to-peer interaction on diabetes self-care. Future research is needed to establish efficacy and safety in recommending social media use among peers for diabetes self-care and other conditions.
A Review on Drug of Pediatric Pulmonary Arterial Hypertension (PAH), their Chemistry and Pharmaceutical Dosage Forms
Authors: Dubey Rupal , Pothuvan Umadoss , Bhamare Pankaj , Singh Alka , Upmanyu Neeraj 
Published: April 2020

Hypertension, specifically pulmonary hypertension, is a syndromethat can affect pediatric patients as well as adults. Pulmonary arterial hypertension (PAH) in pediatric patients, while rare, can be a lifethreateningcondition. There is no cure for PAH, only treatment options forchildren that are largely based on the results of adult studies. These therapies, however, can improve quality of life and survival. Treatment can be challenging because of the less approved medications and tolerable dosage forms for pediatric patients. Pediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. Current classes of medications primarily used to treat pediatric hypertension include phosphodiesterase inhibitors, endothelin receptor antagonists, and prostacyclins. Additional agents that may be utilized in selected pediatric patients include calcium channel blockers, anticoagulants, and inhalednitric oxide. Updates are provided on issues related to utility of the previous classification system to reflect pediatric-specific aetiologies and approaches to medical and interventional management of PAH. Also updates are provided about currently available drug substance and their details, pharmaceutical dosage forms and their details along with the mechanism of action, pharmacokinetics of the drug. These emerging data are improving the identification of appropriate targets for goal-oriented therapy inchildren. Such data will likely improve future advanced pharmaceutical dosage development and product design to enhance outcomes in pediatric PAH.
Keywords: Pulmonary arterial hypertension, pediatric hypertension, PAH
EFFECT OF DURUM WHEAT BRAN ON GLUCOSE AND LIPID METABOLISM IN DIABETIC RATS.
Authors: Tarfaoui Louiza , Menadi Noreddine , Meziani Samira , Zairi Mohamed , Bekhaled Iméne , Benalia Abdelkrim , Boukhatmi Fafa , Sennous Kadour , Demmouche Abassia 
Published: April 2020

Introduction.Durum wheat bran is obtained from wheat milling, it’s considered as an excellent source of insoluble dietary fibre. Objective. The aim of this paper was to evaluate the effect of wheat bran (WB) on glucose and lipid metabolism in normal and diabetic rats. Materials and Methods. Twenty-four female rats of "Wistar" were divided into four groups each containing six rats. The first group (NCR) was fed by a control diet while the second group (NCRE) was fed by the experimental diet based on durum wheat bran. For the third and fourth group after streptozotocin (STZ) injection, they were fed by a control diet (DCR) and experimental diet (DRE) respectively. The Blood Glucose (g/L) and weight (g) of these groups was measured at the end of each week for a period of four weeks, the serum lipid parameters in the fasting condition, such as TC, TG, LDL-C and HDL-C were evaluated at the end of the experience. Results. WB was high in dietary fibre (41%). The results show a significant decrease in blood glucose ( p<0.04) and body weight ( p<0.05 ) in DRE group compared to DCR group and non-diabetic groups. No significant difference was observed for cholesterol and triglyceride levels, a difference of p<0.05 for HDL-C was observed between the diabetic experimental diet group and the non-diabetic control diet group. For LDL-C, the difference was observed between the diabetic experimental group and the non-diabetic experimental group (p<0.001). Conclusion Our results indicated that WB exerting a glycemic and a serum lipid regulation effect in experimental diabetic rats.
A Concise Review Based on Analytical Method Development and Validation of Apremilast in Bulk and Marketed Dosage Form
Authors: Khadse Saurabh C. , Chalikwar Shailesh S. , Firke Sandip D. , Baviskar Harshal Ramkrishna , Umale Akshay D. 
Published: April 2020

Apremilast is used for treatment of psoriasis and psoriatic arthritis. It may also be beneficial for other inflammatory diseases relevant to the immune system. The drug functions as a selective enzyme phosphodiesterase 4 (PDE4) inhibitor and avoids the spontaneous development of TNF-alpha from human synovial rheumatoid cells. The present review assesses the different approaches for evaluation of apremilast in bulk material as well as different formulations. A concise review consists of compile and discuss about over 30 methods for analysing apremilast in the biological matrices, the samples of bulk and in different dosage formulations including HPLC, HPTLC, UPLC, LC-MS and UV-spectrophotometry. A concise review represents the compilation and discussion of about more than 30 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of apremilast in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on apremilast.
Keywords: Apremilast; Analytical Profile; HPLC; HPTLC; Bioanalytical; Stability indicating
Evaluation of Antidiabetic and Antihyperlipidemic Effect of Ethanolic Leaves Extract of Centratherum anthelminticum (L) Kuntze against STZ Induced Diabetic Rats
Authors: Goutam Nidhi , Kapoor Reni 
Published: April 2020

Objective: To evaluate the Antidiabetic & Antihyperlipidemic effect of Centratherum Anthelminticum (L) Kuntze extract against STZ induced diabetic rats.
Methods: The present study examined the influence of Centratherum Anthelminticum extract (CASE), on blood glucose level and antioxidant enzymes level in STZ induced diabetic rats. The possible effects of chronic administration of the extract on the fasting serum glucose, insulin, and total cholesterol and triglycerides levels in STZ-induced diabetic rats were also evaluated.
Results: The extracts showed a marked Antidiabetic & Antihyperlipidemic effect. Centratherum anthelminticum ethanolic seeds extract is capable of exhibiting glycemic control through its inhibitory effect on glycogenolytic enzyme glycogen phosphorylase, gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bis phosphatase and stimulatory effect on hexokinase, which is the key enzyme in the glycolytic pathway.
Antihyperlipidemic activity of Centratherum anthelminticum ethanolic seeds extract proved by restoration of altered lipid profile
Conclusions: The results of the study indicate that the extract of Centratherum anthelminticum possesses strong antidiabetic & antihyperlipidemic activity. This study also describes therapeutic effect of Centratherum anthelminticum in diabetes which will give a new direction for the future scientific research.
Keywords: Diabetes, Centratherum anthelminticum, Pharmacological, Antidiabetic, Antihyperlipidemic
Synthesis and Biological Evaluation of Benzimidazoles as Target for α-Glucosidase Inhibitors
Authors: Mishra Shweta , Dahima Rashmi , Sharma Rajesh 
Published: April 2020

Diabetes mellitus is rising globally touching more than 180 million people worldwide. This is prevailing mostly in type 2 diabetes and according to WHO report the incidence is likely to be more than doubled by 2030. α-glucosidase inhibitors work by reducing the amount of glucose that the intestines absorb from food. In our previous work, forty-five benzimidazoles analogues were studied using 3D QSAR, HQSAR, and Pharmacophore mapping and based on their results 60 compounds were designed. Docking studies of those designed compounds showed that most of the compounds are bonding with important amino acids LEU 520, ARG 335 and ASP 69 through hydrogen bonds and steric interaction. In this work, synthesis of eleven compounds was done on the basis of molecular docking studies. Compounds containing hydroxyl and alkyl groups (compound no. 3, 9 and 10) were found to be five to eight folds more active with IC90 values in the range of 6.02 ± 1.10 to 33.25 ± 1.20 µg/ml, in comparison with the standard drug, Acarbose (IC90= 290.55 ± 0.081 µg/ml). Thus, these compounds after the toxicity studies could be of therapeutic use in treating diabetes.
Keywords: Acarbose, Alpha-glucosidase inhibition, Benzimidazoles, Docking, Molecular modelling, Post-prandial hyperglycemia
Relation between BMI and Semen parameters in male infertility patients in west of Algeria
Authors: Ferrag Dalila , Demmouche Abbassia , Zine Charaf Khalloua 
Published: April 2020

Introduction: Body mass index BMI is a risk factor that influences semen quality and reduces male fertility. The aim of this study was to determine the impact of body mass index (BMI) on semen parameters in infertile men.
Subject and method: A total of 446 infertile men, the study population was divided into four groups depending on their BMI , underweight (<18.5 kg/), normal weight (18.5-24.99 kg/m2 ), overweight 25-29.99 kg/m2), and obese >30.0 kg/.semen parameters (PH, volume, concentration ,total semen count ,vitality, morphology and motility ) were compared across the four BMI groups.
Results: The mean of age was 41.91±6.39, the mean infertility duration was 4.92±3.28, 351(78.7٪) had primary infertility and 95(21.3٪) had secondary infertility. The mean BMI was 29.38± 4.85 and the most of patients 45.2٪ were obese.
Conclusion: This study has found evidence of an association between BMI and semen parameters (Sperm concentration, Total sperm count, motility, and vitality) and no correlation between Semen volume, morphology and BMI.
Keywords: Body mass index, male infertility, semen quality, west of Algeria
Phytochemical Screening and Antioxidant Activities of Different Organic Extracts of Three Algerian Plants
Authors: Rezzoug Maria , Bakchiche Boulanouar , Gherib Abdelaziz , Elasri Ouahid 
Published: April 2020

We compared the phytochemical constituents and antioxidant activities of three important species of Lamiaceae in Algeria (Mentha spicata, Ocimum basilicum and Thymus algeriensis). We noticed that the M. spicata species contains the largest fraction of phenolic and flavonoid products (231 and 22 mg / g) than the other two species studied. Other hand we founded that the two species M. spicata and T. algeriensis show excellent antioxidant activity in the ethanolic extract according to the two tests (DPPH and ABTS) compared to the ascorbic acid of reference. But the specie O. basilicum has good antioxidant activity in aqueous extraction. This Lamiaceae family takes an important place in the lives of Algerians citizens, so this species are very good source of natural antioxidant compounds in algerian traditional medicine.
Keywords: Antioxidant activity, Lamiaceae, Mentha spicata, Ocimum basilicum and Thymus algeriensis, DPPH.
Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Chloroform extract of Argemone mexicana
Authors: Taware Ganesh Virsen , Lokesh Kavita R , Jain Alok Pal 
Published: April 2020

Aim: The present study was undertaken to examine the effects of Chloroform extract of Argemone mexicana using the paracetamol-induced liver damage in rats as the animal model.
Materials and methods: Chloroform extract of Argemone mexicana (100 and 200 mg/kg body weight) was administered daily in experimental animals. The hepatoprotective efficacy of Chloroform extract of Argemone mexicana (100 and 200 mg/kg) was investigated against paracetamol-induced hepatotoxicity. The levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), serum alkaline phosphatase (ALP), bilirubin and triglycerides were estimated. Moreover, chloroform extract of Argemone mexicana -aided antioxidant defense against hepatotoxic insult of paracetamol was measured by evaluating a number of anti-oxidative biomarkers including reduced malondialdehyde (MDA) in the serum.
Results: Oral administration of paracetamol (500 mg/kg b.wt.) resulted in a significant elevation of liver enzymes in serum such as SGOT, SGPT, ALP, bilirubin and triglyceride levels when compared with the results in the control group. As regards oxidative stress biomarkers, there were increased tissue levels of malondialdehyde in the group treated with paracetamol. All of these results were ameliorated by co-administration of chloroform extract of Argemone mexicana.
Conclusions: These results suggest that the protective role of Chloroform extract of Argemone mexicana in the prevention of PCM-induced hepatic toxicity in rats was associated with a decrease of oxidative stress in hepatic tissues.
Keywords: Antihepatotoxicity; Chloroform extract of Argemone mexicana; Paracetamol
Trends in Social Support Experienced by Pacific Men and Women over the Adult Lifespan: An Age-Based Latent Growth Model
Authors: Kapeli Sarah Ann , Manuela Sam , Milojev Petar , Sibley Chris 
Published: April 2020

Introduction: Our study investigated the development of social support experienced by Pacific men and women across the adult lifespan in New Zealand (18 to 65 years of age).
Methods: We examined differences in social support using data from the first six annual waves of the New Zealand Attitudes and Values Study (N = 501 women and 238 men) using an age-based latent growth model.
Results and Discussion: Mean levels of social support decreased as Pacific peoples aged. More specifically, Pacific men demonstrated a significant decrease in social support and older Pacific men demonstrated the lowest levels of support of all Pacific peoples. In comparison, Pacific women maintained higher levels of social support compared to Pacific men, with social support remaining relatively stable across the lifespan of Pacific women.
Conclusion: Our research explores the importance of social support and its link to health and wellbeing among Pacific communities in New Zealand. This is important because we need to understand the factors that could buffer outcomes of low social support such as mental illness and possibly suicide among Pacific peoples.
“Não me aquenta, nem me arrefenta”: considerações a propósito da origem e evolução dos verbos terminados em -entar em português
Authors: Pereira Rui Abel Rodrigues 
Published: April 2020

Os verbos terminados em -entar, como amolentar, apodrentar, avelhentar, endurentar, enfraquentar, adormentar, acrescentar ou afugentar, têm suscitado, ao longo dos anos, análises diversas no que diz respeito à sua morfologia e/ou ao seu modo de construção. Este subconjunto de verbos derivados é especialmente interessante pois não apenas nos fornece pistas sobre o processo de geração e de desaparecimento dos afixos, como também permite analisar como se desenrola o fenómeno de competição afixal (cf. amolentar vs. amolecer; apodrentar vs. apodrecer).Neste artigo, para além de apresentarmos as questões fundamentais que a descrição destes verbos suscita em termos lexicogenéticos, analisaremos o percurso diacrónico do constituinte derivacional -entar desde os primórdios da nossa língua, avaliando os efeitos do fenómeno de competição mantido com outros processos verbalizadores, especialmente com aqueles que envolvem o elemento sufixal -ecer.
Second Binormal Motions of Inextensible Curves in 4-dimensional Galilean Space
Authors: Korkmaz Fatma Bulut , Bektaandş Mehmet 
Published: April 2020

Abstract
In our study, we give the associated evolution equations for curvature and torsion as a system of partial differential equations. In addition, we study second binormal motions of inextensible curves in 4-dimensional Galilean space.
Zawahiru Ta'tsiru al Lughah al Arabiyah fi al Lughah al Hausawiyyah
Authors: Abdullah Yaqub Alhaji 
Published: April 2020

Arabic language is known as a language of Islam and the holy Quur’an.It is also a language of culture and civilization that provide the needs of its speakers at all levels and has over come the challenges of time. Arabic as a language has influenced different languages, especially the language of muslims in different part of the world. Hausa language is a clear example of such influence. Thus, this paper is an attempt to examine different aspect at which Arabic language has influence Hausa language. The inductive method was adopted in the research to draw examples and bring out similarities between the two languages. The findings of this paper therefore established that Hausa linguistic aspect that were influenced by Arabic language includes; aspect of some pronoun, formation of word, feminine gender and the usage of Arabic meter in composing Hausa poem. These affirmed the long term relationship between the two languages and confirmed the advancement of Arabic language.
Determinação do volume de anestésico local para bloqueio espinal toracolombar (T13-L3), em cães com peso entre 20 e 40kg
Authors: Damasceno Kassia Fernanda Araujo , Almeida Maria Raquel de , Leite Jacinta Eufrasia Brito , Tudury Eduardo Alberto 
Published: April 2020

Já é reconhecido que os bloqueios nervosos com anestésicos locais são capazes de aliviar a sensação dolorosa severa, possibilitando ainda no trans-operatório uma anestesia geral mais superficial, com menores transtornos cardiovasculares e respiratórios, diminuindo assim os riscos anestésicos. O bloqueio epidural toracolombar, por ser um tipo de anestesia regional, pode cumprir estes requisitos ante à dor gerada por cirurgias espinais toracolombares, comum em cães com doença do disco intervertebral (DDIV). Este trabalho experimental utilizando cadáveres, teve como objetivo verificar o volume necessário de anestésico local para viabilizar a realização de bloqueio espinal toracolombar de T13 até L3 em cães com peso entre 20 e 40 kg, que necessitassem de neurocirurgias descompressivas por DDIV. Foram utilizados 10 cadáveres de cães com este intervalo de peso, sem histórico de afecção espinal, onde se mediu o comprimento em centímetros, da coluna vertebral T13-L3. Foi colocado um cateter no espaço epidural pelo forame vertebral de L5, L6 ou L7 até à vértebra L3 e realizada secção vertebral entre T12- T13 para visualização do forame vertebral de T13 e verificação do volume de solução de corante Giemsa necessário para que o mesmo chegasse nesse local, quando injetado pelo cateter com sua ponta situada exatamente caudal à L3. Posteriormente foi injetada a solução diluída de contraste de bário e se verificou (pela extensão do contraste na radiografia) que o volume determinado com o corante Giemsa foi suficiente para o preenchimento epidural da junção toracolombar a ser submetida à descompressão medular, caso o animal tivesse uma protrusão discal. Com esses resultados foram calculadas médias e desvio padrão do volume por cm de coluna vertebral entre T13 e L3. O volume de solução de anestésico que deveria se aplicar por cm de coluna vertebral entre T13 e L3 oscilaria entre 0,059 e 0,109ml, com média e desvio padrão de 0,084±0,01683ml.
PENGARUH LATIHAN PULL OVER TERHADAP KEMAMPUAN SMASH PADA PERMAINAN BULUTANGKIS
Authors: Sudiadharma Sudiadharma , Ishak Muhammad 
Published: April 2020

This study aims to determine the effect of pull over training on smash ability in badminton games. This research is experimental. The population is UNM FIK students. The sample used was 20 people consisting of 10 people in each training group. The sampling technique is ordinal matching. The data analysis technique used was descriptive analysis, requirements test, and t-test at a significant level of 95% or 0.05. The results showed that: (1) There was a significant effect of pull over training on smash ability in badminton games, with the value of t count = -11,000 <from t table = 1,833 at a significant level of 95% or 0.05. (2) There is an insignificant influence of the control group on smash ability in badminton games. The value of t count = -6,000 <from t table = 1,833 at a significant level of 95% or 0.05. (3) There is a difference in effect between pull over and control groups on smash ability in badminton games by obtaining t count = 3.674> from t table = 1.833 and P value (0.546> 0.05)