bluuebunny/crossref_metadata_2025_split huggingface dataset:
MENUJU KEHARMONISAN KELUARGA DARI AYAT-AYAT NUSYUZ DAN SYIQAQ
Authors: Jannah Roudhotul 
Published: July 2020

<p>Eksistensi perempuan berada pada sistem paradoksal (kondisi positif dan negatif tentang eksistensi perempuan dalam kehidupan), sebagaimana keadaan perempuan yang dianggap memprihatinkan, dengan terkungkung dalam sistem budaya patriarki, mengakibatkan timbulnya perlawanan, seperti gerakan feminisme, yang berupaya melakukan pemberontakan terhadap tatanan masyarakat yang ada, yang mereka anggap bersifat patriarkis, termasuk terhadap ide-ide teologis (agama) dan institusi sosial kultural yang sering dituduh sebagai pangkal dari ketidakadilan sistemik perempuan. Menurut penulis, gerakan feminis seperti ini justru merusak keharmonisan tatanan kehidupan, bahkan syari’at yang telah diajarkan dalam Agama Islam yang sudah proporsional. Adapun metode penafsiran yang relevan untuk pembahasan ini adalah metode penafsiran kontekstual milik Abdullah Saeed, yang menawarkan aplikasi penafsiran yang sesuai dengan konteks kekinian. Dari penelitian inilah penulis menemukan bahwa Al-Qur’an telah memberikan tawaran solusi yang arif dan bijak untuk menghadapi perempuan yang melakukan <em>nusyu&gt;z</em> dan <em>syiqa&gt;q</em>, dengan ketentuan yang diuraikan dalam QS. Al-Nisa&gt;’ [4] ayat 34 dan 35, yaitu beberapa tahapan solusi yang harus dilakukan dalam menghadapi perempuan<em> nusyu&gt;z</em> dan <em>syiqa&gt;q</em>, yaitu memberikan nasihat yang baik serta melakukan tindakan-tindakan persuasif (<strong>فَعِظُوهُنَّ</strong><strong>), </strong>selanjutnya pisah ranjang (<strong>وَاهْجُرُوهُنَّ فِي الْمَضَاجِعِ</strong>), yang dimaksudkan adalah menghentikan hubungan seksual sementara waktu sehingga membuat istrinya jera dan merasa bersalah. Dan sebagai langkah terakhir adalah memukul ( <strong>وَاضْرِبُوهُنَّ</strong> ), sebagai suatu langkah-langkah fisikal dan dengan ketentuan tidak menyakitkan dan tidak berbekas. Namun, jika keduanya tetap berselisih maka perlu <em>h}akam </em>(<em>h}akamain</em>), yang berfungsi sebagai pemdamai di antara keduanya. Maksud dari keseluruhan ayat tentang <em>nusyu&gt;z</em> dan <em>syiqa&gt;q </em>ini adalah bahwa pada hakikatnya ajaran yang terkandung dalam Al-Qur’an adalah kedamaian dan kasih-sayang, yang menjadi perwujudan dari ajaran <em>Islam Rahmatan lil "alamin<br /></em></p>
ЭПИДЕМИЧЕСКИЙ ПРОЦЕСС COVID-19 В РОССИЙСКОЙ ФЕДЕРАЦИИ: ПРОМЕЖУТОЧНЫЕ ИТОГИ. СООБЩЕНИЕ 1.
Authors: Пшеничная Наталья 
Published: July 2020

В статье дан промежуточный анализ компонентов эпидемического процесса COVID-19 в Российской Федерации на основании
статистического анализа данных формы отчета Роспотребнадзора №970 «Информация о случаях инфекционных заболеваний у лиц с подозрением на новую коронавирусную инфекцию» за январь–июнь 2020 г. Описываются особенности эпидемического процесса в Москве и Московской области и остальных регионах России. Проводится анализ взаимосвязи степени тяжести заболевания с возрастом, полом, а также сроком обращения за медицинской помощью.
Electrocuted Hip: Late Consequences of Electrical Shock Injuries of Orthopaedic Relevance
Authors: Khan Yasim , Arora Sumit , Gupta Swati , Mahajan Nidhi , Sural Sumit , Dhal Anil 
Published: July 2020

Case:
A 43-year-old man suffered household electric shock from 220 V alternating current when he accidently touched a live wire with his left hand. Subsequently, he was diagnosed to have osteonecrosis of the left femoral head and underwent total hip arthroplasty.

Conclusion:
We suggest that the electric current could have thrombosed the terminal subsynovial vessels of the femoral head, leading to osteonecrosis. To the best of authors' knowledge, only 2 cases of osteonecrosis of the hip after electric shock have been reported in the literature. A literature review of the delayed consequences of electric shock injuries pertaining to orthopaedics is also presented.
Rare Variant Double-Layered Lateral Meniscus Detected During Arthroscopy in a Young Gymnast After a Hyperextension Knee Injury
Authors: Looney Austin M. , Ferris William J. , West Robin V. 
Published: July 2020

Case:A 15-year-old high-level gymnast sustained a hyperextension knee injury and was diagnosed with a lateral meniscus tear on advanced imaging. During arthroscopy, a redundant meniscus was encountered overlying an otherwise normal, intact lateral meniscus, consistent with a double-layer lateral meniscus. The redundant meniscus was resected, and the patient was able to return to gymnastics at her previous high level of competition.Conclusions:Abnormalities of the lateral meniscus may be poorly characterized or undetected on preoperative imaging studies. When the decision is made to proceed with surgery, a vigilant diagnostic arthroscopic examination can facilitate the detection and treatment of unanticipated pathology.
Temporal Trends in the Rates of Singletons, Twins and Higher-order Multiple Births Over Five Decades Across Racial Groups in the United States
Authors: Wang Liye , Dongarwar Deepa , Salihu Hamisu M. 
Published: July 2020

We analysed Natality data obtained from the National Vital Statistics System from 1971 through 2018. Overall, the rates of singletons declined among all racial groups over the five decades of the study. However, the rates of twins and higher-order multiples increased over the same period although for the past two decades, the rates of higher-order multiples had substantially plummeted. The global health implication of these findings is that policy changes in the US in the form of professional practice guidelines have succeeded in reducing the birth of vulnerable populations (i.e., higher-order multiples) who are predominantly created using assisted reproductive technology.
Key words: • Trends in Multiple Gestations • US • Black • White • Singletons • Twins • Higher-order multiples

Copyright © 2020 Wang et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
The Effect of On-site CT-derived Fractional Flow Reserve on the Management of Decision Making for Patients with Stable Chest Pain (TARGET Trial): Objective, Rationale and Design
Authors: yang junjie , shan dongkai , wang zhiqiang , dong mei , ma xiang , hu xinyang , zeng hesong , chen yundai 
Published: July 2020

Abstract
Background: The diagnostic accuracy of CT-derived Fractional Flow Reserve (CT-FFR) in clinical application has been well validated. This advanced technology focus on evaluating anatomical stenosis and functional ischemia simultaneously. However, the effect of CT-FFR on the management of decision making has not been fully evaluated in randomized controlled design. Method/design: TARGET study is a pragmatic, multicentre, prospective, open-label and randomized controlled trial evaluating the effect of a CTA/CT-FFR strategy (Group A) versus usual care (Group B) on intermediate-to-high risk patients with suspected CAD who undergo clinically indicated diagnostic evaluation. A total sample size of 1216 subjects will be enrolled and followed up for 12 months. This study will be performed in 6 Chinese hospitals, and the primary endpoint is the planned ICA without significant obstructive CAD within 90 days. The secondary endpoints include major adverse cardiovascular event, quality of life, medical expenditure, and cumulative radiation exposure during 1-year follow-up.Conclusion: The study will provide information to patients, health care providers and other stakeholders in China about which strategy could be more effective in the management of intermediate-to-high risk patients with suspect CAD.Trial registration:ClinicalTrials.gov, NCT03901326, Registered on 03 April 2019.
Investigation of Cadmium Content in Rice in Heilongjiang Province and Health Risk Assessment
Authors: Cao Dongmei , Zhang Chang , Zhang Dongjie 
Published: July 2020

Abstract
We investigated the cadmium content in soils and rice in Cha Hayang, Wuchang, Fangzheng, Xiangshui, and Jiansanjiang areas of Heilongjiang Province, and characterized the effect of rice intake on human health. The samples were analyzed by ICP-MS, and the cadmium transfer in soil-rice system was modeled by the Nemero comprehensive pollution index method. The health risk assessment model was used to study the status of cadmium pollution in rice and its health risk assessment for adults and children. The results showed that the average contents of cadmium in rice were 0.003 (Cha Hayang), 0.016 (Wuchang), 0.006 (Fangzheng), 0.006 (Xiangshui), and 0.005 (Jiansanjiang) mg kg-1. The prediction model developed in this study, including the total heavy metals and pH value of the soil, effectively described the transfer of cadmium in the soil-rice system of Wuchang, Chahayang and Xiangshui paddy fields (with R2 between 0.256 and 0.468). The pollution index of the study area was less than 1. The comprehensive pollution index was 0.037<1, sugesting no pollution, and the comprehensive pollution index was between 0.059 and 0.158. The health risk index of carcinogenic heavy metal cadmium to adults and children in Cyang and JianSanjiang areas was lower than that recommended by USEPA (1 × 10-4), suggesting no risk of cancer. However, the mean values in Wuchang, Fang Zheng and Xiangshui were higher than the maximum acceptable risk recommended by USEPA, suggesting a risk of cancer.
Rate, determinants, and causes of stillbirth in Jordan: Findings from the Jordan Stillbirth and Neonatal Deaths Surveillance (JSANDS) system
Authors: Shattnawi Khulood Kayed , Khader Yousef S. , Alyahya Mohammad S. , Al-Sheyab Nihaya , Batieha Anwar 
Published: July 2020

Abstract
Background: Annually, 2.6 million stillbirths occur around the world, with about 98% occur in low and middle-income countries. The stillbirth rates in these countries are 10 times higher than the rates in high-income countries. Methods: An electronic stillbirths and neonatal deaths surveillance system (JSANDS) was established in five large hospitals located in three of the largest cities in Jordan in August 2019. JSANDS was developed as a secure on-line data entry system to collect, organize, analyse, and disseminate data on stillbirths, neonatal deaths, and their contributing conditions. Data on births, stillbirths and their contributing conditions contributing, and other demographic and clinical characteristics in the period between August 2019 – January 2020 were extracted and analysedResults: A total of 10328 births were registered during the reporting period. Of the total births, 102 were born dead (88 antepartum stillbirths and 14 intrapartum stillbirths) with a rate of 9.9 per 1000 total births. The main contributing fetal conditions of antepartum stillbirths were antepartum death of unspecified cause (33.7%), acute antepartum event (hypoxia) (33.7%), congenital malformations and chromosomal abnormalities (13.3%), and disorders related to the length of gestation and fetal growth (10.8%). The main contributing maternal conditions of antepartum stillbirths included complications of placental cord and membranes (48.7%), maternal complications of pregnancy (23.1%), and maternal medical and surgical conditions (23.1%). Contributing fetal conditions of intrapartum stillbirths included congenital malformations deformations and chromosomal abnormalities, other specified intrapartum disorder, intrapartum death of unspecified cause (33.3% each). Contributing maternal conditions of intrapartum stillbirths included complications of placental cord and membranes. In the multivariate analysis, the odds of stillbirth for very low birth weight (<1500 gm) babies and for low birthweight babies (1500-2499 gm) were 14.1 times 4.3 times that odds for babies born with normal birth weight, respectively. The stillbirth rate was significantly higher among preterm deliveries compared to full-term deliveries (OR = 5.6). Conclusions: Although the rate of stillbirth is lower than that in other countries in the region, there is an opportunity to prevent such deaths. While the majority of stillbirths occurred during the antepartum period, care should be taken for early identification of high-risk pregnancies and ensuring adequate antenatal obstetric interventions.
Assessment of the risk of permanent stoma after low anterior resection in rectal cancer patients
Authors: Zeman Marcin , Czarnecki Marek , Chmielarz Andrzej , Idasiak Adam , Grajek Maciej , Czarniecka Agnieszka 
Published: July 2020

Abstract
Background: One of the most severe complications of low anterior rectal resection is anastomotic leakage (AL). The creation of a loop ileostomy (LI) reduces the prevalence of AL requiring surgical intervention. However, up to one-third of temporary stomas may never be closed.The first aim of the study was to perform a retrospective assessment of the impact of LI on the risk of permanent stoma (PS) and symptomatic AL. The second aim of the study was to assess preoperative PS risk factors in patients with LI.Methods: A total of 286 consecutive patients who underwent low anterior rectal resection were subjected to retrospective analysis. In 101 (35.3%) patients, diverting LI was performed due to low anastomosis, while in the remaining 185 (64.7%) patients, no ileostomy was performed. LIs were reversed after adjuvant treatment. Analyses of the effect of LI on symptomatic AL and PS were performed. Among the potential risk factors for PS, clinical factors and the values ​​of selected peripheral blood parameters were analysed.Results: PS occurred in 37.6% and 21.1% of the patients with LI and without LI, respectively (p <0.01). Symptomatic ALs were significantly more common in patients without LI. In this group, symptomatic ALs occurred in 23.8% of patients, while in the LI group, they occurred in 5% of patients (p <0.001). In the LI group, the only significant risk factor for PS in the multivariate analysis was preoperative plasma fibrinogen concentration (OR = 1.007, 97.5% CI 1.002-1.013, p = 0.013).Conclusions: Although protective LI may reduce the incidence of symptomatic AL, it can be related to a higher risk of PS in this group of patients. The preoperative plasma fibrinogen concentration can be a risk factor for PS in LI patients and may be a useful variable in decision-making models.
An In-silico Deep Learning Approach to Multi-epitope Vaccine Design: A SARS-CoV-2 Case Study
Authors: Yang Zikun , Bogdan Paul , Nazarian Shahin 
Published: July 2020

Abstract
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over 6.5 million cases and more than 380,000 deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy, vaccines are urgently needed to avoid the spread of this disease. In this study, we propose an in-silico deep learning approach for prediction and design of a multi-epitope vaccine (Deep-Vac-Pred). By combining the in-silico immunotherapeutic and deep neural network strategies, the DeepVacPred computational framework directly predicts 26 potential vaccine subunits from the available SARS-CoV- 2 spike protein sequence. We further use in-silico methods to investigate the linear B-cell epitopes, Cytotoxic T Lymphocytes (CTL) epitopes, Helper T Lymphocytes (HTL) epitopes in the 26 subunit candidates and identify the best 11 of them to construct a multi-epitope vaccine for SARS-CoV-2 virus. The human population coverage, antigenicity, allergenicity, toxicity, physicochemical properties and secondary structure of the designed vaccine are evaluated via state-of-the-art bioinformatic approaches, showing good quality of the designed vaccine. The 3D structure of the designed vaccine is predicted, refined and validated by in-silico tools. Finally, we optimize and insert the codon sequence into a plasmid to ensure the cloning and expression efficiency. In conclusion, this proposed artificial intelligence vaccine discovery framework accelerates the vaccine design process and constructs a 694aa multi- epitope vaccine containing 16 B-cell epitopes, 82 CTL epitopes and 89 HTL epitopes, which is promising to fight the SARS-CoV-2 viral infection and can be further evaluated in clinical studies. Moreover, we trace the RNA mutations of the CoV and make sure our designed vaccine can tackle the recent RNA mutations of the virus.
Sexual Dysfunction and Metabolic/Hormonal Changes in Women Using Long-Term Hormonal and Non-Hormonal Contraceptives
Authors: Moreira Igor Fernando de aquino , Bianchini Maria Passos , Moreira Gabrielle Rodrigues Campos , Almeida Alessandra Maciel , Rezende Bruno Almeida 
Published: July 2020

Abstract
Background
Female sexual dysfunction is a common condition that negatively impacts the emotional health and quality of life of the affected individuals. Long-acting reversible contraceptives (LARCs) are becoming increasingly popular due to their effectiveness and convenience. LARCs can be hormonal (etonogestrel releasing implant—ENG and Levonorgestrel intrauterine system—LNG) or non-hormonal (copper intrauterine device—CuIUD and copper-silver intrauterine device—SIUD). There are very few studies that assess the influence on LARCS on sexual function are lacking.This study aimed to assess changes in sexual function as well as metabolic and hormonal parameters in women after implantation with LARCs.
Methods
In this prospective cohort study, we assessed 80 women who visited the Military Police Hospital in Brazil for LARCs placement. The study participants were divided into 4 groups according to the type of LARC received: ENG n = 17; LNG n = 21, CuIUD n = 18 and SIUD n = 23. The four groups were evaluated twice (prior to LARC placement and approximately 3 months later) for sexual function, using the Female Sexual Function Index (FSFI) and Female Sexual Quotient (QS-F) questionnaires. Metabolic and hormonal parameters were also assessed using blood tests. p < 0.05 was considered to indicate statistical significance.
Results
We observed an improvement in sexual function with CuIUD placement according to QS-F (p < 0.017) and SIUD (FSFI: p = 0.06 and QS-F: p < 0.001). However, ENG worsened sexual function according to FSFI and QS-F (p < 0.001 and p = 0.003), across all domains. A decrease in sex hormone-binding globulin (SHBG) was observed for all groups (LNG: p = 0.019; ENG: p = 0.024; CuIUD: p = 0.010; SIUD: p = 0.022) and an increase in total testosterone levels (p = 0.007 and p = 0.003) and prolactin (p = 0.049 and p = 0.001) with CuIUD and SIUD placement. Hemoglobin levels increased with LIS (p < 0.001) and ENG (p = 0.025) and decreased with CuIUD placement (p < 0.001).
Conclusion
The use of non-hormonal LARCS improved sexual function, especially in the desire domain. Etonogestrel implants, had a negative influence on sexual function, probably by blocking ovarian function, and thus reducing the production of androgens and estrogens. SIUD placement was superior as it improved sexual function, interfered less with hormonal levels, and did not decrease hemoglobin levels.
On two cases of atypical respiratory distress in eastern Democratic Republic of the Congo months before the COVID-19 pandemic was declared: Could SARS-Cov-2 have been already spreading? Case report
Authors: MATESO Guy-Quesney , BAGUMA Marius , MWENE-BATU Pacifique , BALEMBA Ghislain MAHESHE , NZABARA Fabrice , MAKALI Samuel , BEDHA Aline , FURAHA Bonheur , MINANI Jimmy , MUHINDO Christian TSHONGO , MALEMBAKA Espoir BWENGE , MASIMANGO Mannix Imani , SHINDANO Tony Akilimali , CIKOMOLA Justin Cirhuza , MUBAGWA Kanigula 
Published: July 2020

Abstract
BackgroundPredictions have been made that Africa would be the most vulnerable continent to the novel coronavirus disease 2019 (COVID-19). Interestingly, the spread of the disease in Africa seems to have been delayed and initially slower than in many parts of the World. Here we report on two cases which make us suspect that COVID-19 might have been present in our region before the official declaration of the disease in December 2019.Case presentationThese two cases (one 55-year-old man and one 25-year-old woman) of acute respiratory distress secondary to atypical pneumonia were seen in Bukavu, in eastern Democratic Republic of the Congo (DRC), between September and December 2019. One patient had returned from China and the other had close contacts with travellers from China in the 2 weeks prior to the onset of symptoms. In either case, the aetiology could not be accurately determined. However, the two cases presented a clinical picture (progressive dyspnoea, preceded by dry cough and fever) and laboratory changes (procalcitonin within the normal range, slight inflammation, and lymphopenia) compatible with a viral infection. The chest X-Rays series of the first patient showed lesions (reticulations, ground glass, and nodules ≤ 6 mm) similar to those found in COVID-19. In addition, unlike the 25-year-old female patient who had no comorbidity, the 55-year-old male patient who had hypertension as comorbidity, developed a more severe acute respiratory distress which progressed to death.ConclusionThese cases bring to the attention a number of facts which make us suspect that the COVID-19 epidemic may have already been present in the region months before the official beginning of the pandemic.
Study on mechanism of the Hanshi Zufei syndrome formula for COVID-19 based on network pharmacology
Authors: Zheng Wenjiang , Ni Yongshi , Yan Qian , Huang Ying , Li Jiqiang , Liu Xiaohong , Jiang Yong 
Published: July 2020

Abstract
Objective

To study the mechanisms of Hanshi Zufei syndrome formula (HSZF) for coronavirus disease 2019 (COVID-19) using network pharmacology.
Methods

We screened the potential active constituents (oral bioavailability [OB] ≥ 30%, drug-likeness [DL] ≥ 0.18) of HSZF using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, predicted targets using the Swiss TargetPrediction database, constructed a pharmacologically active-compound–potential-target network and a protein–protein interaction (PPI) network using Cytoscape software, and used the org.Hs.eg.db and ClusterProfiler data packages in R language software to perform gene ontology (GO) biological-function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the potential targets of HSZF.
Results

A total of 170 effective active constituents, such as Genkwanin, diosmetin, wogonin, quercetin, kaempferol, luteolin, and herbacetin were obtained through oral OB and DL screenings. These constituents act on targets such as kininogen-1 (KNG1), epidermal growth factor receptor (EGFR), Caspase-3 (CASP3), signal transducer and activator of transcription 3 (STAT3), EStrogen Receptor 1 (ESR1), angiotensin-converting enzyme 2 (ACE2), and myeloperoxidase (MPO); participate in biological processes such as cellular metal ion homeostasis, calcium ion homeostasis, unsaturated fatty acid metabolism, and positive regulation of phospholipase activity; and treat COVID-19 through pathways such as apoptosis, calcium signaling, phospholipase D signaling, arachidonic acid metabolism, platelet activation, renin–angiotensin system (RAS), and inflammatory-mediator regulation of transient receptor potential (TRP) channels.
Conclusion

Flavonoids are important in the mechanism by which HSZF treats COVID-19. Inhibition of inflammatory response and regulation of both immune function and cell apoptosis might be important mechanisms of HSZF for this disease.