bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β42aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease
Authors: Khelifi Imen , Tourrette Audrey , Dhouafli Zohra , Bouajila Jalloul , Efferth Thomas , Abdelfatah Sara , Ksouri Riadh , Hayouni El Akrem 
Published: December 2019

AbstractAlzheimer's disease is characterized by amyloid β aggregation and cholinergic neurodegeneration. In the present study, pure DDN (2,3‐dichloro‐5,8‐dihydroxy‐1,4‐naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Aβ42aggregation. Such investigation was encouraged by thein vitrohigh antioxidant potential of DDN. Indeed, it revealed interesting antioxidant activity with IC50values of 9.8 and 4.3 µM for ABTS and reducing power, respectively. The ability of DDN to counteract Aβ42aggregation was evaluated by thioflavine‐T assay. Strong inhibition of Aβ42aggregation of more than 90% at 25 µM was measured. Moreover, results showed that DDN inhibited AChE (IC50= 14.5 µM). To better understand the interactions between DDN and AChE, molecular docking was performed. Obtained data predicted a high interaction characterized by hydrogen bonding at TYR337 as for galanthamine (positive control). Several residues involved in AChE hydrophobic interactions were similarly implicated in binding of this domain to DDN (ASP74, THR83, and TYR124). All these data would be useless if DDN could not pass the blood–brain barrier. So, DDN was loaded into alginate microspheres to enhance its stability and bioavailability. Thereafter, drug release profiles were assessed using immersion cell apparatus.
Distribution of congenital anomalies by race/ethnicity and geospatial location in Oklahoma, 1997–2009
Authors: Janitz Amanda E. , Dao Hanh Dung , Campbell Janis E. , Stoner Julie A. , Peck Jennifer D. 
Published: December 2019

AbstractIntroductionCongenital anomalies were the leading cause of infant mortality, responsible for 23 and 21% of deaths in Oklahoma and the USA, respectively, in 2016. We aimed to determine the prevalence by race/ethnicity and spatial distribution of congenital anomalies to identify geographic and racial/ethnic disparities, particularly among American Indian/Alaska Natives (AI/AN).MethodsWe evaluated the prevalence of anomalies by type and race/ethnicity among 648,074 live births in Oklahoma from 1997 to 2009. Prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) were calculated using Poisson regression. We used Moran's I and Getis‐Ord Gi* to evaluate spatial clustering for neural tube defects, critical congenital heart defects (CCHDs), and oral clefts among births whose residence geocoded to the ZIP code or finer level.ResultsOverall prevalence of anomalies among live births was 3.9%. Non‐Hispanic (NH) African American (PPR: 0.87, 95% CI: 0.83, 0.91), Asian/Pacific Islander (PPR: 0.70, 95% CI: 0.63, 0.78), and Hispanic (PPR: 0.87, 95% CI: 0.83, 0.91) children had a lower prevalence of anomalies compared to NH whites. The prevalence in NH AI/AN children was similar to NH whites (PPR: 1.01, 95% CI: 0.97, 1.05). However, differences in specific types of anomalies were observed by race/ethnicity. We observed no spatial autocorrelation for CCHD and oral clefts. Neural tube defects demonstrated spatial autocorrelation (p < .0001). Local hot spots varied by anomaly.DiscussionThe prevalence of anomalies by race/ethnicity and geography differed by race/ethnicity and region, though this varied by anomaly. Additional research is needed to identify behavioral or environmental factors to target for prevention.
ISO 14001, EMAS and environmental performance: A meta‐analysis
Authors: Erauskin‐Tolosa Artitzar , Zubeltzu‐Jaka Eugenio , Heras‐Saizarbitoria Iñaki , Boiral Olivier 
Published: December 2019

AbstractThe adoption of voluntary environmental certifications such as ISO 14001 and Eco‐Management and Audit Scheme (EMAS) has gained momentum in the last two decades. The scholarly literature has analyzed in depth the performance implications of the adoption of these certificates. Yet the findings are scattered and inconclusive. This article aims to shed light on this issue by meta‐analyzing the influence of the adoption of voluntary environmental certifications on corporate environmental performance, drawing on a sample of 53 scholarly studies analyzing a total of 182,926 companies. The findings show a positive influence of ISO 14001 and EMAS certifications on corporate environmental performance. A set of underlying moderating effects are also identified, such as a more pronounced positive effect for adoptions based on environmental innovation and for firms with a more mature certification. Implications for scholars, managers, and other stakeholders are discussed.
Physicochemical properties of enzymatically modified pea protein‐enriched flour treated by different enzymes to varying levels of hydrolysis
Authors: Konieczny Dellaney , Stone Andrea K. , Korber Darren R. , Nickerson Michael T. , Tanaka Takuji 
Published: December 2019

AbstractBackground and objectivesAir‐classified pea protein‐enriched flour (PPEF) was modified with trypsin, Savinase, papain, and pepsin to achieve 2%–4% and 10%–12% degrees of hydrolysis, and the surface and functional properties of the hydrolyzed products were assessed.FindingsSurface hydrophobicity increased from 13.3 to 48.5 A.U. with papain treatment. Surface charge became more electronegative from −12.6 to −19.0 mV with pepsin treatment. However, solubility of hydrolyzed PPEF at all pH values tested (4.0, 7.0, and 10.0), regardless of enzyme treatment, decreased. Low solubility of hydrolyzed proteins negatively impacted solubility‐dependant functional properties: foaming properties and emulsifying properties decreased. However solubility‐independent properties (water‐ and oil‐holding capacity; WHC and OHC, respectively) improved with proteolysis, increasing from 0.6 g/g to 1.4–2.0 g/g and from 0.7 g/g to 1.0–1.5 g/g, respectively.ConclusionsPapain treatment yielded the best results in terms of both OHC and WHC of PPEF.Significance and noveltyThe resultant hydrolyzates have potential for baked goods and processed meat applications because of their increased OHC and WHC.
vWFpp/ADAMTS13 ratio is a useful marker of postliver transplantation thrombotic microangiopathy: A pediatric case report
Authors: Duquenne Lisa , Balbeur Samuel , Everard Emilie , Reding Raymond , Eeckhoudt Stéphane , Brichard Bénédicte , Godefroid Nathalie , Derycke Emilien , Komuta Mina , Scheers Isabelle , Smets Françoise , Sokal Etienne , Stéphenne Xavier 
Published: December 2019

AbstractvWFpp/ADAMTS13 ratio should be further studied as a useful marker for diagnosis of thrombotic microangiopathy postliver transplantation. Immunosuppressive regimen modification and plasma supplementation can lead to recovery.
Improved Interfacial Bonding Strength and Reliability of Functionalized Graphene Oxide for Cement Reinforcement Applications
Authors: Wang Nan , Wang Shuping , Tang Luping , Ye Lilei , Cullbrand Björn , Zehri Abdelhafid , Tebikachew Behabitu Ergette , Liu Johan 
Published: December 2019

AbstractPoor bonding strength between nanomaterials and cement composites inevitably lead to the failure of reinforcement. Herein, a novel functionalization method for the fabrication of functionalized graphene oxide (FGO), which is capable of forming highly reliable covalent bonds with cement hydration products, and therefore, suitable for use as an efficient reinforcing agent for cement composites, is discussed. The bonding strength between cement and aggregates was improved more than 21 times with the reinforcement of FGO. The fabricated FGO also demonstrated many important features, including high reliability in cement pastes, good dispersibility, and efficient structural refinement of cement hydration products. With the incorporation of FGO, cement mortar samples demonstrated up to 40 % increased early and ultimate strength. Such results make the fast demolding and manufacture of light constructions become highly possible, and show strong advantages on improving productivity, saving cost, and reducing CO2 emissions in practical applications.
A Constrained and “Inverted” [3+3] Salphen Macrocycle with an ortho‐Phenylethynyl Substitution Pattern
Authors: Urbani Maxence , Torres Tomas 
Published: December 2019

AbstractA [3+3] Schiff‐base salphen macrocycle (7 a) was synthesized by imine condensation between ortho‐phenylenediamine and ortho‐phenylethynyl‐bridged bis(5‐salicylaldehyde) precursors. The triangular‐shaped macrocycle 7 a has a nonclassical (or “inverted”) design in which the N2O2 coordination pockets are located at the sides instead of the corners. Compound 7 a could be synthesized in a reasonably good yield (64 %) considering the steric constraints imposed by the ortho substitution pattern. Subsequent zinc metalation afforded the corresponding Zn metallomacrocycle 7 b. Spectroscopic experiments evidenced weak (7 a) to strong (7 b) self‐aggregation behavior in solution. Their ability to self‐organize at the supramolecular level was further studied in the solid state by AFM and TEM, which revealed the formation of large bundles of fibers with lengths of several micrometers and widths of nanometers.
Synthesis of Enaminone‐Pd(II) Complexes and Their Application in Catalysing Aqueous Suzuki‐Miyaura Cross Coupling Reaction
Authors: Fu Leiqing , Cao Xiaoji , Wan Jie‐Ping , Liu Yunyun 
Published: December 2019

Summary of main observation and conclusionA series of Pd(II)‐enaminone complexes, termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)‐reagents has proved that the Pd(eao)2‐1 possesses excellent catalytic activity for the Suzuki‐ Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol‰). The superiority of this Pd(II)‐reagent to those commercial Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments. What's more, Pd(eao)2‐2 has been found as a practical catalyst for the homo‐coupling reactions of aryl boronic acids.
Wage losses among spouses of women with nonmetastatic breast cancer
Authors: Humphries Brittany , Lauzier Sophie , Drolet Mélanie , Coyle Douglas , Mâsse Benoît , Provencher Louise , Robidoux André , Maunsell Elizabeth 
Published: December 2019

BackgroundThe aim of this study was to evaluate the wage losses incurred by spouses of women with nonmetastatic breast cancer in the 6 months after the diagnosis.MethodsA prospective cohort study of spouses of women diagnosed with nonmetastatic breast cancer who were recruited in 8 hospitals in the province of Quebec (Canada) was performed. Information for estimating wage losses was collected by telephone interviews conducted 1 and 6 months after the diagnosis. Log‐binomial regressions were used to identify personal, medical, and employment characteristics associated with experiencing wage losses, and generalized linear models were used to identify characteristics associated with the proportion of usual wages lost.ResultsOverall, 829 women (86% participation) and 406 spouses (75% participation) consented to participate. Among the 279 employed spouses, 78.5% experienced work absences because of breast cancer. Spouses were compensated for 66.3% of their salary on average during their absence. The median wage loss was $0 (mean, $1820) (2003 Canadian dollars). Spouses were more likely to experience losses if they were self‐employed or lived 50 km or farther from the hospital. Among spouses who experienced wage losses, those who were self‐employed or whose partners had invasive breast cancer lost a higher proportion of wages.ConclusionsAlthough spouses took some time off work, for many, the resulting wage losses were modest because of compensation received. Still, the types of compensation used may hide other forms of burden for families facing breast cancer.
Evaluation of BRAF, RAS, RET/PTC, and PAX8/PPARg alterations in different Bethesda diagnostic categories: A multicentric prospective study on the validity of the 7‐gene panel test in 1172 thyroid FNAs deriving from different hospitals in South Italy
Authors: Bellevicine Claudio , Migliatico Ilaria , Sgariglia Roberta , Nacchio Mariantonia , Vigliar Elena , Pisapia Pasquale , Iaccarino Antonino , Bruzzese Dario , Fonderico Francesco , Salvatore Domenico , Biondi Bernadette , Masone Stefania , Novizio Vincenzo , Scavuzzo Francesco , Serino Domenico , De Palma Maurizio , Chiofalo Maria Grazia , Botti Gerardo , Pezzullo Luciano , Nuzzo Vincenzo , Spiezia Stefano , De Chiara Giovanni , Iorio Sergio , Conzo Giovanni , Docimo Giovanni , Faggiano Antongiulio , Bongiovanni Massimo , Malapelle Umberto , Colao Annamaria , Triassi Maria , Troncone Giancarlo ,   for the Tiroide Network
Published: December 2019

BackgroundThyroid fine‐needle aspiration (FNA) is a reliable and cost‐effective diagnostic tool for establishing the nature of thyroid nodules, although up to 30% of FNAs are still classified as “indeterminate.” Molecular testing of FNAs could improve preoperative diagnosis, thereby reducing unnecessary surgery. In this multicenter prospective study the authors investigated, using a 7‐gene assay, the distribution and diagnostic impact of BRAF, RAS, RET/PTC, and PAX8/PPARg, the most frequent genomic alterations occurring during thyroid oncogenesis.MethodsIn total, of 1172 routine FNAs from 7 centers in southern Italy were classified according to the Bethesda System for Reporting Thyroid Cytopathology. Each specimen was tested, and molecular data were compared with available histology or cytologic follow‐up.ResultsIn particular, for atypia of undetermined significance/follicular lesion of undetermined significance cases, the 7‐gene test confirmed the high positive predictive value of BRAFV600E and BRAF‐like mutations (80%) and the moderate positive predictive value of RAS‐like alterations (32.4%), suggesting different surgical management, depending on the type of mutation. The rate of mutation‐positive FNAs was strictly related to the risk of malignancy of each diagnostic class, supporting the identification of prognostically relevant diagnostic categories.ConclusionsThe 7‐gene panel test improves the preoperative risk stratification of indeterminate thyroid FNAs, especially when considering the biologic significance of the different types of mutations. Moreover, the rate of mutation‐positive FNAs is related to the risk of malignancy of each diagnostic class.
Coronary artery plaque growth: A two‐way coupled shear stress–driven model
Authors: Arzani Amirhossein 
Published: December 2019

AbstractAtherosclerosis in coronary arteries can lead to plaque growth, stenosis formation, and blockage of the blood flow supplying the heart tissue. Several studies have shown that hemodynamics play an important role in the growth of coronary artery plaques. Specifically, low wall shear stress (WSS) appears to be the leading hemodynamic parameter promoting atherosclerotic plaque growth, which in turn influences the blood flow and WSS distribution. Therefore, a two‐way coupled interaction exists between WSS and atherosclerosis growth. In this work, a computational framework was developed to study the coupling between WSS and plaque growth in coronary arteries. Computational fluid dynamics (CFD) was used to quantify WSS distribution. Surface mesh nodes were moved in the inward normal direction according to a growth model based on WSS. After each growth stage, the geometry was updated and the CFD simulation repeated to find updated WSS values for the next growth stage. One hundred twenty growth stages were simulated in an idealized tube and an image‐based left anterior descending artery. An automated framework was developed using open‐source software to couple CFD simulations with growth. Changes in plaque morphology and hemodynamic patterns during different growth stages are presented. The results show larger plaque growth towards the downstream segment of the plaque, agreeing with the reported clinical observations. The developed framework could be used to establish hemodynamic‐driven growth models and study the interaction between these processes.
Multiobjective noncooperative game model for cost‐based task scheduling in cloud computing
Authors: Gao Ziyan , Wang Yong , Gao Yifan , Ren Xingtian 
Published: December 2019

SummaryTask scheduling is an important issue in Cloud Computing. Cloud Computing often covers a range of different kinds of nodes, which offers a complex environment. To handle this complexity, as while as to process task scheduling in different scenarios of Cloud Computing, many algorithms have been studied. In this paper, we propose a game theory–based algorithm to the Cloud Computing task scheduling problem on the principle of minimizing the cost in the Cloud Computing. The Cloud Computing task scheduling problem is treated as a noncooperative game. The experiment results demonstrate that the game‐based algorithm has a desirable capability to reduce the cost in the Cloud Computing.
Efficient MPI‐AllReduce for large‐scale deep learning on GPU‐clusters
Authors: Thao Nguyen Truong , Wahib Mohamed , Takano Ryousei 
Published: December 2019

SummaryTraining models on large‐scale GPUs‐accelerated clusters are becoming a commonplace due to the increase in complexity and size in deep learning models. One of the main challenges for distributed training is the collective communication overhead for large message sizes: up to hundreds of MB. In this paper, we propose two hierarchical distributed memory multileader AllReduce algorithms optimized for GPU‐accelerated clusters (named lr_lr and lr_rab), in which GPUs inside a computing node perform an intra‐node communication phase to gather and store results of local reduced values to designated GPUs (known as node leaders). Node leaders then keep a role as an inter‐node communicator. Each leader exchanges one part of reduced values to the leaders of the other nodes in parallel. Hence, we are capable of significantly reducing the time for injecting data into the inter‐node network. We also overlap the inter‐node and intra‐node communication by implementing our proposal in a pipelined manner. We evaluate those algorithms on the discrete‐event simulation Simgrid. We show that our algorithms, lr_lr and lr_rab, can cut down the execution time of an AllReduce microbenchmark that uses the logical ring algorithm (lr) by up to 45% and 51%, respectively. With the pipelined implementation, our lr_lr_pipe achieves 15% performance improvement when compared with lr_lr. In addition, the simulation result also projects power savings for the network devices of up to 23% and 32%.
Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study
Authors: Lee Yeon‐Hee , Hong Junshik , Kim Inho , Choi Youngnim , Park Hee‐Kyung 
Published: December 2019

AbstractObjectiveThe objective of this study was to prospectively evaluate the clinical features of chemotherapy‐induced oral mucositis (CIOM) in adult patients with acute leukemia and the aggravating factors for such symptoms.SubjectsThirty‐seven prospective patients aged ≥19 years with acute leukemia undergoing chemotherapy were enrolled. Oral and clinical investigations were performed at baseline and on Day 14 after starting chemotherapy. The presence and severity of cancer‐induced oral mucositis were demonstrated using the World Health Organization (WHO) scoring system.ResultsOn Day 14, we found that oral mucositis had developed in eight patients (21.6%). Hematopoietic stem cell transplantation (HSCT) in patients was a predictor of increased WHO scores (β = 1.937, p < .001). Regarding oral sites, ventral tongue (β = 1.670), soft palate (β = 1.242), and buccal mucosa (β = 0.593) were predictors for increased scores. In addition, the increase in WHO scores was positively correlated with the number of oral lesions (r = .521), the difficulty in eating (r = .250), and the overall oral health (r = .534; all p < .05).ConclusionThe main factors affecting the severity of CIOM symptoms were the treatment with HSCT and the location of oral lesions. The incidence of CIOM and WHO scores were not significantly different between the subgroups of disease. Our findings will help clinicians investigate the oral findings after chemotherapy in adult patients with acute leukemia.
Cytomorphologic features of small cell carcinoma of lung in effusion fluid using a liquid‐based cytology technique
Authors: Kim Lucia , Choi Suk‐Jin , Park In‐Suh , Han Jee‐Young , Kim Joon‐Mee , Chu Young‐Chae 
Published: December 2019

AbstractBackgroundLiquid‐based cytology (LBC) testing induces morphologic changes due to the use of specific fixatives and preparation techniques, and the cytologies of effusions determined in this manner differ morphologically from those of conventional cytopreparation (CCP) smear methods. We compared the cytologic features of pulmonary small cell carcinoma in effusion fluid using CCP and LBC preparations.MethodsFifty‐three malignant effusion specimens from 36 patients with small cell carcinoma were examined, including 41 LBCs from 27 patients and 12 CCPs from 9 patients.ResultsLBC and CCP preparations preserved the typical features of small cell carcinoma, that is, nuclear molding, very high nuclear to cytoplasmic ratio and granular chromatin. The architectural patterns involved small cohesive clusters and chains with nuclear molding, tight three‐dimensional clusters, or single cell dispersion were preserved in both preparations. Oval nuclei (83.3% vs 26.8%, P < .001) and a discernable rim of cytoplasm (66.7% vs 26.8%, P = .043) were more frequently identified in CCPs, whereas cellular degeneration and dry artifact were more frequent in LBC preparations (73.2% vs 8.3%, P < .001). LBC had a tendency to show frequent nuclear size variation (51.2% vs 25.0%) than CCP.ConclusionLBC tends to show more degeneration and dry artifact with exaggerated irregular nuclear shape and nuclear size variation and scanty cytoplasm than CCP. Cytopathologists should be familiar with the cytomorphologic spectrum of this tumor in CCP and LBC prepared effusions.