bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sifu - a cybersecurity awareness platform with challenge assessment and intelligent coach
Authors: Espinha Gasiba Tiago , Lechner Ulrike , Pinto-Albuquerque Maria 
Published: December 2020

AbstractSoftware vulnerabilities, when actively exploited by malicious parties, can lead to catastrophic consequences. Proper handling of software vulnerabilities is essential in the industrial context, particularly when the software is deployed in critical infrastructures. Therefore, several industrial standards mandate secure coding guidelines and industrial software developers’ training, as software quality is a significant contributor to secure software. CyberSecurity Challenges (CSC) form a method that combines serious game techniques with cybersecurity and secure coding guidelines to raise secure coding awareness of software developers in the industry. These cybersecurity awareness events have been used with success in industrial environments. However, until now, these coached events took place on-site. In the present work, we briefly introduce cybersecurity challenges and propose a novel platform that allows these events to take place online. The introduced cybersecurity awareness platform, which the authors call Sifu, performs automatic assessment of challenges in compliance to secure coding guidelines, and uses an artificial intelligence method to provide players with solution-guiding hints. Furthermore, due to its characteristics, the Sifu platform allows for remote (online) learning, in times of social distancing. The CyberSecurity Challenges events based on the Sifu platform were evaluated during four online real-life CSC events. We report on three surveys showing that the Sifu platform’s CSC events are adequate to raise industry software developers awareness on secure coding.
The Importance of Keeping Time in the Liver
Authors: McCommis Kyle S , Butler Andrew A 
Published: December 2020

AbstractThe liver is a “front line” in the homeostatic defenses against variation in nutrient intake. It orchestrates metabolic responses to feeding by secreting factors essential for maintaining metabolic homeostasis, converting carbohydrates to triglycerides for storage, and releasing lipids packaged as lipoproteins for distribution to other tissues. Between meals, it provides fuel to the body by releasing glucose produced from glucogenic precursors and ketones from fatty acids and ketogenic amino acids. Modern diets enriched in sugars and saturated fats increase lipid accumulation in hepatocytes (nonalcoholic fatty liver disease). If untreated, this can progress to liver inflammation (nonalcoholic steatohepatitis), fibrosis, cirrhosis, and hepatocellular carcinoma. Dysregulation of liver metabolism is also relatively common in modern societies. Increased hepatic glucose production underlies fasting hyperglycemia that defines type 2 diabetes, while increased production of atherogenic, large, triglyceride-rich, very low-density lipoproteins raises the risk of cardiovascular disease. Evidence has accrued of a strong connection between meal timing, the liver clock, and metabolic homeostasis. Metabolic programming of the liver transcriptome and posttranslation modifications of proteins is strongly influenced by the daily rhythms in nutrient intake governed by the circadian clock. Importantly, whereas cell-autonomous clocks have been identified in the liver, the complete circadian programing of the liver transcriptome and posttranslational modifications of essential metabolic proteins is strongly dependent on nutrient flux and circadian signals from outside the liver. The purpose of this review is to provide a basic understanding of liver circadian physiology, drawing attention to recent research on the relationships between circadian biology and liver function.
An assessment of the correlation between robust CT-derived ventilation and pulmonary function test in a cohort with no respiratory symptoms
Authors: Nair Girish B , Galban Craig J , Al-Katib Sayf , Podolsky Robert , van den Berge Maarten , Stevens Craig , Castillo Edward 
Published: December 2020

Objective:
To evaluate CT-ventilation imaging (CTVI) within a well-characterized, healthy cohort with no respiratory symptoms and examine the correlation between CTVI and concurrent pulmonary function test (PFT).

Methods:
CT scans and PFTs from 77 Caucasian participants in the NORM dataset (clinicaltrials.gov NCT00848406) were analyzed. CTVI was generated using the robust Integrated Jacobian Formulation (IJF) method. IJF estimated total lung capacity (TLC) was computed from CTVI. Bias-adjusted Pearson’s correlation between PFT and IJF-based TLC was computed.

Results:
IJF- and PFT-measured TLC showed a good correlation for both males and females [males: 0.657, 95% CI (0.438–0.797); females: 0.667, 95% CI (0.416–0.817)]. When adjusting for age, height, smoking, and abnormal CT scan, correlation moderated [males: 0.432, 95% CI (0.129–0.655); females: 0.540, 95% CI (0.207–0.753)]. Visual inspection of CTVI revealed participants who had functional defects, despite the fact that all participant had normal high-resolution CT scan.

Conclusion:
In this study, we demonstrate that IJF computed CTVI has good correlation with concurrent PFT in a well-validated patient cohort with no respiratory symptoms.

Advances in knowledge:
IJF-computed CTVI’s overall numerical robustness and consistency with PFT support its potential as a method for providing spatiotemporal assessment of high and low function areas on volumetric non-contrast CT scan.
Desenvolvimento econômico na região da RIBA a partir da relação crescimento-desigualdade sob hipótese(s) da(s) curva(s) de Kuznets
Authors: Carvalho Rhayza Alves Figueiredo de , Carvalho Abner Vilhena de , Guimarães Jarsen Luis Castro 
Published: December 2020

O presente ensaio teve como objetivo analisar a possível relação do crescimento econômico e desigualdade na Região de Integração do Baixo Amazonas (RIBA), no período de 2000 e 2010. Por meio de investigação da(s) hipótese(s) curva de Kuznets, a partir da construção de um modelo econométrico com dados em painel curto, usando como proxies da desigualdade e do crescimento econômico os seguinte indicadores: o índice de Gini (variável dependente), e a renda per capita (variável independente), respectivamente, sendo esta última utilizado sob a forma linear, cúbica e quadrática, a fim de testar os possíveis resultados das curva no formato de U-invertido e N, de modo a contribuir para a discussão no campo da economia do desenvolvimento na região. Os resultados do modelo apontaram para evidencia da hipótese do U-invertido da curva de Kuznets presente no primeiro estágio do progresso econômico na região, corroborando com o pressuposto teórico muito embora, em níveis agregados, a influência da evolução crescente da renda per capita possa ser interpretado, também, como apaziguador na evolução crescente da desigualdade de renda, atuando assim, o crescimento econômico como pacificador momentâneo junto à desigualdade de renda na RIBA.
Ativismo judicial e a instrumentalidade do processo: um diálogo com Georges Abboud e Guilherme Lunelli a partir da obra de Cândido Rangel Dinamarco
Authors: Branco Carolina Nobre Castello , Santiago Nestor Eduardo Araruna 
Published: December 2020

Este artigo tem como objetivo investigar se a teoria da instrumentalidade do processo, elaborada por Cândido Rangel Dinamarco, contribuiu para o ativismo judicial. De natureza qualitativa, tem por objeto a crítica à teoria da instrumentalidade do processo publicada em um artigo científico de autoria de Georges Abboud e Guilherme Lunelli. Mediante uma abordagem dialética, o estudo se concentra em destacar os principais argumentos críticos dos autores para fins de avaliação e confrontação teórica. Inicialmente é feita uma análise da relação apresentada pelos autores entre o ativismo judicial e a instrumentalidade do processo, para compreender os argumentos que fomentaram suas conclusões. Posteriormente, avaliou-se o constitucionalismo contemporâneo, evidenciando-se suas influências na evolução do sistema processual e no conceito de jurisdição. Por fim, o trabalho se concentra em demonstrar os motivos pelos quais o instrumentalismo deve ser compreendido como uma forma de obter o acesso à justiça e não como um estímulo ao ativismo judicial.
Considerações sobre o institucionalismo de Maurice Hauriou: bases filosóficas e verificação histórica.
Authors: Cicco Cláudio De 
Published: December 2020

O presente artigo visa relembrar a produção de um autor que,não se sabe bem por que, anda meio esquecido em nosso país: Maurice Hauriou. Tirou-o do imerecido ostracismo o saudoso Prof.Miguel Reale em seus Fundamentos do Direito,publicado em 4ªedição pela Editora Migalhas,em 2014. Com efeito, trata-se de pensador e jurista francês que trouxe para o cenário jurídico o que considera o máximo problema da Filosofia do Direito: a passagem da situação de fato para o nível imperativo da norma jurídica. Terçaram armas a esse respeito juristas como Émile Durkheim,o criador da Sociologia Jurídica, os neokantianos Rudolf Stammler, Georg Jellinek, Gustav Radbruch, pai do culturalismo jurídico. A solução de Maurice Hauriou mostra ser mais inteligente, pois integra os fatos sociais em torno de um objetivo racionalmente aceito como a busca da ordem social mais justa, sem considerá-la uma quimera, sem cair em hipóteses arriscadas como ponto de partida, nem reduzir o direito apenas à dimensão normativa, fática ou axiológica. Veremos que não se trata de caminho inexplorado até então, mas da retomada da crítica contra o racionalismo que, de Descartes a Kant, empolgou a intelectualidade europeia e cujo maior representante no campo político foi Jean-Jacques Rousseau, com enorme repercussão no campo jurídico, tendente a um voluntarismo, transferido da vontade do príncipe para a vontade da multidão, tornando-se secundário o aspecto justiça de uma norma jurídica,de acordo com o cínico aforisma: “Potestas,non sapientia,facit legem”= é o poder, e não a sabedoria que faz a lei.”A crítica veio da Escola Histórica do Direito de Frederico Carlos von Savigny, mas esta, ainda que acertadamente lembrasse a importância da história das nações na formação do direito, soava como nostálgica e mesmo romântica,como defesa do passado para condenar a Revolução Liberal. Não é esta a filosofia de Maurice Hauriou, que se volta para a história com olhar evolucionista e dinâmico na linha de Henri Bergson, por isso considerado por Miguel Reale como o “Bergson da Ciência do Direito”. E Bergson, como se sabe, foi uma reação contra o idealismo kantiano, mostrando pontos de contato entre as ciências humanas e as ciências naturais, no seu clássico livro “L’Évolution Créatrice”(A Evolução Criadora) que logrou ser laureada com o Prêmio Nobel. Temos que frisar que a grande contribuição de Hauriou é a idéia de instituição. O direito nasce nas instituições de que o Estado é uma espécie importantíssima, mas não a única. No momento em que se discute em nosso país o gigantismo do Estado e se deseja abrir cada vez mais espaço para a sociedade civil, formada por pessoas com dignidade própria, vinculadas por um ideal comum em instituições representativas, este artigo pode ser portador de alguma luz, para basear toda uma revisão de conceitos consagrados dogmaticamente, sem exame crítico algum.
O software R e a pesquisa com Alimentos e Nutrição
Authors: Ferreira Eric Batista 
Published: December 2020

O software R surge com a criação da linguagem de programação R. Criada pelos pesquisadores Brian Ripley e Bill Venables (Figura 1a e 1b), a linguagem R tem a aparência da linguagem S e a semântica da linguagem Scheme. Particularmente, na pesquisa em Alimentos e Nutrição, o software R desempenha importante papel na análise, visualização e predição de dados.
A aula: do culto ao novo à complexidade do contemporâneo
Authors: Boff Daiane Scopel , Neves Antônia Regina Gomes , Fabris Elí Terezinha Henn 
Published: December 2020

O artigo discute os entrelaçamentos entre inovação e indissociabilidade teoria-prática a partir de uma perspectiva que as toma como integrantes do arquivo da docência. Ao operar com teorizações do campo da formação de professores e da docência, além de conceitos das áreas de sociologia e filosofia em uma perspectiva hipercrítica, discorre-se sobre discursividades que constituem uma das regiões do arquivo – a aula –, para depois analisar como a dicotomia teoria-prática opera nos sentidos atribuídos à docência. O material empírico foi produzido a partir de análise fílmica, adaptada ao gênero documentário, e entrevistas semiestruturadas com professores que desenvolvem a docência em cursos de licenciatura. A analítica realizada mostra que, no arquivo da docência, se produzem discursividades que reforçam a dicotomia teoria-prática e a intensificação do novo. A partir disso, aponta-se a indissociabilidade teoria-prática como uma possibilidade qualificada para pensar a formação, a docência e a aula, considerando as complexidades do contemporâneo.
The true cost of dental implant tourism: A case report
Authors: Greval Jasem , Motaleb Labibah , Bhatia Sunil 
Published: December 2020

Many patients travel abroad seeking cosmetic dental treatment, in particular dental implants. However, there are hundreds of dental implant systems being used globally by dentists of all training backgrounds. Furthermore, complications can occur that patients may expect their general dental practitioner in the UK to be able to manage. The following report describes the case of a 71-year-old, medically compromised patient who presented with complaints consistent with the immediate failure of dental implants that happened to be placed abroad. On closer examination, the dental implants themselves were highly questionable in their design and placement. An incidental finding was also made in the maxillary sinus. CPD/Clinical Relevance: To acknowledge that implant dentistry is increasing in popularity as patients have the freedom to access dental implant treatment globally. UK dentists are expected to manage these dental implants on the return of patients to the UK who may present with post-operative complications involving unknown dental implant systems.
Skin surface infrared thermography in pressure ulcer outcome prognosis
Authors: Bilska Anna , Stangret Aleksandra , Pyzlak Michal , Wojdasiewicz Piotr , Szukiewicz Dariusz 
Published: December 2020

Objective:To assess the usefulness of skin surface infrared thermography (SSIT) as a prognostic tool in the treatment of stages III and IV pressure ulcers (PU), with hydrocolloid/hydrogel dressings plus 20 exposures to low-level laser therapy (LLLT), compared with hydrocolloid dressings alone, in a group of long-term bedbound care patients.Method:In this comparative study, participants were randomly assigned to group I: PUs treated with specialist wound dressings and laser therapy, or to group II: PUs treated with specialist wound dressings without laser therapy. Thermal imaging sessions were carried out at the beginning of the study, and after two and four weeks of treatment. Thermal imaging processing was applied to compare percentage differences in the temperature distribution between the groups within selected regions of interest (ROIs). The correlation between the temperature distribution and PU healing was evaluated.Results:A total of 43 patients took part. In the study, three variants of PU healing were observed: pure healing (H) with minimal granulation; healing with hypergranulation (H+G); and non-healing (NH). Analyses of SSIT-related thermographic patterns revealed their dependence on the course of healing. The percentage of successful PU healing reached 79.2% in group I compared with 73.7% in group II (p<0.05) The dominant variant of healing in Group I was H, while in group II the variants H and H+G were present with equal frequency.Conclusion:Thermal imaging processing allowed comparison of differences in the temperature distribution between the groups within ROIs. Application of LLLT significantly improved the healing process (p<0.05). The clinical significance of this finding should be confirmed with larger studies; however, SSIT may be useful as a prognostic tool during the treatment of PUs, with the ability to predict the course of healing initially, that is independent of LLLT treatment.
Antimicrobial resistance—is wound care prepared?
Authors: Bradley Peter 
Published: December 2020

In an Essity-sponsored symposium, entitled ‘Antimicrobial resistance—is wound care prepared?’, four key opinion leaders discussed the difficult journey to managing antimicrobial resistance within wound care at the global and local levels, backed up by the latest research. Peter Bradley summarises the main points they presented at the EWMA 2020 Virtual Conference. This article offers an introduction to the symposium, Antimicrobial resistance—is wound care prepared?, held on 18 November 2020, as part of the EWMA 2020 Virtual Conference. There were four speakers. Claire Kilpatrick, Director, S3 Global and Consultant to the World Health Organization, spoke on ‘Preventing infections and managing antibiotic use—tackling a crisis for the health of nations’. The topic of Karen Ousey, Professor of Skin Integrity, Director for the Institute of Skin Integrity and Infection Prevention, University of Huddersfield, was ‘Antimicrobial stewardship in wound management—less words more action’. Finally, Hadar Lev-Tov, Assistant Professor, and Irena Pastar, Associate Professor, both of the Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami, gave a talk on ‘Silver-resistant bacteria in venous leg ulcers? First results of an exploratory study’.
Use of a biosynthetic wound dressing to treat burns: a systematic review
Authors: Rahimi Farimah , Rezayatmand Reza 
Published: December 2020

Objective: Accelerating the process of wound healing, reducing infection risks, and decreasing pain and discomfort in the burn area are important goals of burn treatment. To achieve these goals, the use of biosynthetic wound dressings has increased in recent years. Suprathel (PolyMedics Innovations, Germany) is a biosynthetic wound dressing used to treat both partial-thickness burns and split-thickness skin graft (STSG) donor sites, full-thickness wounds, large-scale abrasions, and scar revisions. Method: This study is a systematic review of empirical evidence reported on the application of the biosynthetic wound dressing in burns up to 2017. Keywords such as ‘Suprathel’, ‘effectiveness’, ‘safety’, and ‘cost’ were searched in PubMed, Cochrane, Scopus and Embase databases. Results: A total of 14 publications were identified, based on the inclusion and exclusion criteria. The findings reported in the literature reviewed were classified in terms of safety, effectiveness and cost-effectiveness of use of the biosynthetic wound dressing. Regarding safety and effectiveness, the dressing was found to yield desirable results, particularly for partial thickness burns and STSG donor sites. As of 2017 no health economics assessments have been carried out. Conclusion: Despite the desirable advantages of the biosynthetic wound dressing with respect to its effectiveness, safety and ease of use, its major limitation was found to be its cost. However, in the absence of comprehensive studies on the quantification of all factors, there is scant scientific evidence for making reliable conclusions from this systematic review.
Effects of resveratrol on the growth and enzyme production of Stenotrophomonas maltophilia: a burn wound pathogen
Authors: Bharadwaj Sraddha S. , Vaidyanathan Lalitha 
Published: December 2020

Objective: The purpose of this study was to identify the potential of resveratrol in inhibiting the growth and production of two enzymes, hyaluronidase and protease, in Stenotrophomonas maltophilia, which has become a burn wound pathogen of great significance. Method: Stenotrophomonas maltophilia (ATCC 17666) was cultured in nutrient broth and the microbial load was standardised to 0.5 McFarland standard at 600nm. The study included antimicrobial assays (well diffusion and resazurin dye binding method), hyaluronidase expression regulation assay (hyaluronic acid hydrolysis assay and turbidity assay) and protease expression regulation assay (casein hydrolysis assay and determination of specific activity of protease using tyrosine standard). Results: The minimum inhibitory concentration (MIC) of resveratrol against Stenotrophomonas maltophilia was found to be 125µg/ml. Hyaluronidase production in the organism treated with resveratrol was found to be half that in the untreated organism. The specific activity of protease produced by the organism treated with resveratrol was found to be one-quarter that in the untreated organism, as analysed by the tyrosine standard estimation protocol. Conclusion: Resveratrol was found to be a potent compound to treat Stenotrophomonas maltophilia infections. In addition to the antimicrobial and enzyme-regulatory properties of resveratrol, it also shows anti-oxidant and anti-inflammatory properties. This finding has great scope clinically as resveratrol may prove to be an ideal drug to treat burn wound infections.
Plastic and Elastic Strains in Poplar Wood under High-Pressure Densification
Authors: Li Aqiang , Yan Kaiya , Ramaswamy Hosahalli S. , Zhu Songming , Yu Yong 
Published: December 2020

HighlightsHigh-pressure densification (HPD) resulted in more than 100% increase in the density of poplar wood.Density of wood during HPD treatment was up to 300% and 100% higher than observed before and after HPD.A method was developed to measure elastic recovery in the radial and tangential directions under HPD.Abstract. Plastic and elastic strains of poplar wood in the radial and tangential directions were investigated after high-pressure densification (HPD) using a special method that detected the elastic strain. There was a large difference in plastic and elastic strains obtained in compressed wood between the radial and tangential directions. The maximum total strain in the radial and tangential directions reached 26.9% and 66.9%, respectively, when compressed at 150 MPa for 300 s. Longer holding time (300 s) increased the plastic strain, by reducing the elastic strain, when the applied pressure was lower than 60 MPa. In addition, a large difference in compressed wood density prevailed when still under pressure as compared with the density measured after the pressure treatment, and both were nearly 1 to 3 times higher than the density of fresh wood. Further, the maximum density observed under pressure was related to the maximum reported density of dry crystalline cellulose plus the entrapped moisture. The mechanical properties of densified wood were also investigated and found to depend on the pressure treatment conditions. Keywords: Elastic strain, High-pressure densification, Mechanical properties, Plastic strain, Wood density.