bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a novel autophagy-related gene signature for predicting metastasis and survival in patients with osteosarcoma
Authors: Zhang Guangzhi , Deng Yajun , Wu Zuolong , Ren Enhui , Yuan Wenhua , Xie Qiqi 
Published: March 2020

Abstract
Background: Osteosarcoma (OS) is a bone malignant tumor that occurs in children and adolescents. Due to a lack of reliable prognostic biomarkers, the prognosis of OS patients is often uncertain. This study aimed to construct an autophagy-related gene signature to predict the prognosis of OS patients.Methods: The gene expression profile data of OS and normal muscle tissue samples were downloaded separately from the Therapeutically Applied Research To Generate Effective Treatments (TARGET) and Genotype-Tissue Expression (GTEx) databases . The differentially expressed autophagy-related genes (DEARGs) in OS and normal muscle tissue samples were screened using R software, before being subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A protein-protein interaction (PPI) network was constructed and hub autophagy-related genes were screened. Finally, the screened autophagy-related genes were subjected to univariate Cox regression, Lasso Cox regression, survival analysis, and clinical correlation analysis.Results: A total of 120 DEARGs and 10 hub autophagy-related genes were obtained. A prognostic autophagy-related gene signature consisting of 9 genes ( BNIP3 , MYC , BAG1 , CALCOCO2 , ATF4 , AMBRA1 , EGFR , MAPK1 , and PEX ) was constructed. This signature was significantly correlated to the prognosis ( P <0.0001) and distant metastasis of OS patients ( P = 0.013).Conclusion: This signature based on 9 autophagy-related genes could predict metastasis and survival in patients with OS.
The efficacy of single posterior debridement, bone grafting, and instrumentation for the treatment of thoracic spinal tuberculosis
Authors: Zhou Jiao , Li Quanyi , Zhou Yongchun , Song Qichun 
Published: March 2020

Abstract
Background: The aim of this study was to investigate the clinical efficacy of single posterior debridement, bone grafting, and instrumentation for the treatment of thoracic spinal tuberculosis of adult patients. Methods: A retrospective analysis was conducted on 88 adult patients with thoracic spinal tuberculosis between June 2013 and September 2017. All patients were treated with single posterior debridement, bone grafting and instrumentation. The clinical manifestations and laboratory and imaging results of the approach were subsequently analysed. Results: All patients were followed up for 40.6 ± 4.1 m (range, 36–48 m). Bony fusion was achieved in all bone grafts. The VAS scores, ESR, and CRP levels 6 weeks after operation and at the final follow-up were significantly lower than the preoperative levels (P<0.05). The postoperative and final-follow-up kyphosis angles were both significantly smaller than the pre-operative kyphosis angles (P<0.05). The postoperative angle correction rate reached 81.5%, and the postoperative angle loss only reached 4.1%. At the last follow-up, ASIA improvement was significant compared with the preoperative levels (P<0.05). Conclusion: The single posterior approach can achieve satisfactory clinical outcomes in the treatment of thoracic spinal tuberculosis.
Ethnoherpetology and snakebites in a risk area in Northeast Brazil
Authors: Costa Mikaelle Kaline Bezerra da , Alves Rômulo Romeu da Nóbrega , Navoni Julio Alejandro , Freire Eliza Maria Xavier 
Published: March 2020

Abstract
Background Ethnozoology comprehends human interactions with animals, including their knowledge, meaning, and use by societies. In this sense and from the point of view of the human relationship with snakes, this study had the objectives to describe and analyse the level of Ethnozoological knowledge of snakebite accident victims in the semi-arid region of Northeast Brazil. Methods The accident records were accessed through case notifications registered in the SINAN between 2007 and 2016 in the Borborema Potiguar Microregion of Rio Grande do Norte State, specifically in the municipality of Santa Cruz, which was identified as a risk area. An effort was made to locate the snakebite accident victims during this period. Next, a semi-structured questionnaire was applied through an interview to identify the characteristics of the accident, record the victim’s perception of the snake and the accident, their daily life, as well as positive and negative attitudes towards snake conservation and knowledge about species. Information about the possible uses of traditional treatment, allopathic care characteristics along with the symptoms and sequelae resulting from the accident were also recorded. Results The most relevant characteristics detected in these accidents were the strong influence of myths about traditional treatment and the knowledge about identifying common snake species in the region. No perception was detected about the importance of these animals, but there were negative attitudes when finding a snake, thus constituting facts which may be related to the deficiency in the education level of this population which is interfering in environmental and public health issues. Conclusion Work on improving the knowledge and local perception could subsidize actions and policies aimed to prevent accidents, demystify snakes and contribute to the conservation of the species.
The relationship between selected sociodemographic factors and speech organ dysfunction in sporadic ALS patients
Authors: Pawlukowska Wioletta , Baumert Bartłomiej , Gołąb-Janowska Monika , Meller Agnieszka , Machowska-Sempruch Karolina , Wełnicka Agnieszka , Paczkowska Edyta , Rotter Iwona , Machaliński Bogusław , Nowacki Przemysław 
Published: March 2020

Abstract
Background: Speech disorders are observed in 30% of newly diagnosed sporadic amyotrophic lateral sclerosis (ALS) patients. Characterized by a dynamic course, dysfunction of articulation has not so far been well understood. The aim of this study was to analyze the influence of sociodemographic factors (sex, age, duration of the disease) and concomitant diseases (degenerative spine disease, depression, hypertension, hypothyroidism, hyperthyroidism, and allergy) on the functioning of speech organs in ALS patients.Methods: The study group consisted of 65 patients with sporadic ALS. Patients were examined for articulatory functions by means of the Frenchay Dysarthria Assessment (FDA). Results: 68% of the study sample had spinal disorders. Logistic regression analysis showed that a decline in the functioning of lips, soft palate, length of phonation and voice loudness was more common among men. Patients diagnosed with degenerative spine disease more often suffered from respiratory disorders, while younger patients (< 60 years of age) significantly more often had the impairment of the sentence and spontaneous speech functions.Conclusions: The male sex and young age of ALS patients substantially increase the risk of progression of the impairment of speech organs (such as lips, soft palate) and functions (length of phonation, voice loudness, sentence, spontaneous speech). Degenerative spondylogenic changes in the spinal column deteriorated respiratory problems in patients with ALS.
Improving Capacity, Stiffness and Pneumatic Hammer Stability of Aerostatic Thrust Bearing Using Damping Orifice and Virtual Recess
Authors: Ma Wei , Kong Xianglong , Xu Yi 
Published: March 2020

Abstract
An aerostatic thrust bearing is designed using damping orifice and virtual recess. Finite element simulations and measurements are performed and results indicate that with damping orifice and virtual recess, the maximum capacity of the designed aerostatic bearing increases from 1590 N to 2285 N and its maximum stiffness increases from 106 N/μm to 145 N/μm, while the range of pneumatic hammer decreases from 8.5 μm to 4.5 μm at 4 bar. It is therefore concluded that damping orifice and virtual recess are one of the means which can be used to improve the capacity, stiffness and pneumatic hammer stability of aerostatic bearing.An aerostatic thrust bearing is designed using damping orifice and virtual recess. Finite element simulations and measurements are performed and results indicate that with damping orifice and virtual recess, the maximum capacity of the designed aerostatic bearing increases from 1590 N to 2285 N and its maximum stiffness increases from 106 N/μm to 145 N/μm, while the range of pneumatic hammer decreases from 8.5 μm to 4.5 μm at 4 bar. It is therefore concluded that damping orifice and virtual recess are one of the means which can be used to improve the capacity, stiffness and pneumatic hammer stability of aerostatic bearing.
Self-adaptive control system for additive manufacturing using double electrode micro plasma arc welding
Authors: Li Nan , Fan Ding , Huang Jiankang , Yu Shurong , Yuan Wen , Han Miaomiao 
Published: March 2020

Abstract
Wire arc additive manufacturing (WAAM) has been investigated to deposit large-scale metal parts due to its high deposition efficiency and low material cost. However, in the process of automatically manufacturing the high-quality metal parts by WAAM, several problems about the heat build-up, the deposit-path optimization, and the stability of the process parameters need to be well addressed. To overcome these issues, a new WAAM method based on the double electrode micro plasma arc welding (DE-MPAW) was designed. The circuit principles of different metal-transfer models in the DE-MPAW deposition process were analyzed theoretically. The effects between the parameters, wire feed rate and torch stand-off distance, in the process of WAAM were investigated experimentally. In addition, a real-time DE-MPAW control system was developed to optimize and stabilize the deposition process by self-adaptively changing the wire feed rate and torch stand-off distance . Finally, a series of tests were performed to evaluate the control system’s performance . The results show that the capability against interferences in the process of WAAM has been enhanced by this self-adaptive adjustment system. Further, the deposition paths about the metal part’s layer heights in WAAM are simplified. Finally, the appearance of the WAAM-deposited metal layers is also improved with the use of the control system.
Effectiveness of self-help workbook intervention on quality of life in cancer patients receiving chemotherapy: results of a randomized controlled trial
Authors: Takano Toshimi , Matsuda Ayako , Ishizuka Noriko , Ozaki Yukinori , Suyama Koichi , Tanabe Yuko , Miura Yuji , Matsushima Eisuke 
Published: March 2020

Abstract
Background: A self-help workbook is expected to support cancer patients to cope with physical and psychosocial distress, to facilitate communication with medical staff, and to improve quality of life (QOL). We conducted a randomized controlled trial to evaluate the effectiveness of a self-help workbook intervention on QOL and survival. Methods: From June 2014 to March 2015, patients with breast, colorectal, gastric, and lung cancer receiving outpatient chemotherapy were randomized into an intervention group (n = 100) or control group (n = 100). Intervention group participants received workbooks originally made for this study, read advice on how to cope with distress, and filled out questionnaires on the workbooks periodically. EORTC QLQ-C30 was evaluated at baseline, at 12 weeks, and at 24 weeks. The primary endpoint was Global Health Status / QOL scale (GQOL). Results: No significant interaction was observed between the intervention and time in terms of GQOL or any of the functional scales. Among the 69 patients who continued cytotoxic chemotherapy at 24 weeks, the intervention was significantly associated with improved emotional functioning scores (P = 0.0007). Overall survival was not significantly different between the two groups. Conclusions: Self-help workbook intervention was feasible in cancer patients receiving chemotherapy. Although the effect of the intervention was limited, the intervention may improve emotional functioning among patients who receive long-term cytotoxic chemotherapy.Trial registration: UMIN Clinical Trials Registry, UMIN000012842. Registered 14 January 2014, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015002
HIV-Associated Neurocognitive Disorder (HAND) Biomarker Identification: Significance Analysis of Microarrays and Two Persuasive Approaches with Random Forest
Authors: Rodrigo Hansapani , Martinez Bryan , Garza Roberto De La , Roy Upal 
Published: March 2020

Abstract
Background: HIV Associated Neurological Disorders (HAND) is relatively common among people with HIV-1 infection, even those taking combined antiretroviral treatment (cART). Genome-wide screening of transcription regulation in brain tissue helps in identifying substantial abnormalities present in patients’ gene transcripts and to discover possible biomarkers for HAND. This study explores the possibility of identifying differentially expressed (DE) genes, which can serve as potential biomarkers to detect HAND. In this study, we have investigated the gene expression levels of three subject groups with different impairment levels of HAND along with a control group in three distinct brain sectors: white matter, frontal cortex, and basal ganglia.
Methods: Linear models with weighted least squares along with Benjamini-Hochberg multiple corrections were used to identify DE genes in each brain region. Genes with an adjusted p-value of less than 0.01 were identified as differentially expressed. Principal component analyses (PCA) were performed to detect any groupings among the subject groups. Significance Analysis of Microarrays (SAM) and random forests (RF) methods with two distinct approaches were used to identify DE genes.
Results: A total of 710 genes in basal ganglia, 794 genes in the frontal cortex, and 1481 genes in white matter were screened. The highest proportion of DE genes was observed within the two brain regions, frontal neocortex, and basal ganglia. PCA analyses do not exhibit clear groupings among four subject groups. SAM and RF models reveal the genes, CIRBP, RBM3, GPNMB, ISG15, IFIT6, IFI6, and IFIT3, to have DE genes in the frontal cortex or basal ganglia among the subject groups. The gene, GADD45A, a protein-coding gene whose transcript levels tend to increase with stressful growth arrest conditions, was consistently ranked among the top genes by both RF models within the frontal cortex.
Conclusions: Our study contributes to a comprehensive understanding of the gene expression levels of the subject with different severity levels of HAND. Several genes that appear to play critical roles in the inflammatory response have been found, and they have an excellent potential to be used as biomarkers to detect HAND under further investigations.
A szervezeti tényezők szerepe a magyarországi KKV szektor sikerességében
Authors: Almasi Aniko 
Published: March 2020

A tanulmány a hazai KKV szektor sikerességét elemzi a versenyképesség és innováció, a tulajdonos-vezető szerep, illetve a szervezeti tényezők tükrében. A szerző saját, illetve négy hazai empirikus kutatás eredményeinek értékelése alapján arra következtet, hogy a szervezeti innováció jellemzően háttérbe szorul a kis- és közepes vállalkozások működésében, fejlesztési céljaiban és stratégiájában, amiben nagy szerepe van a tulajdonos-vezetőnek. Mindeközben a vállalkozás versenyképességére szignifikánsan ható tényezők között gyakran merül fel a növekedés gátjaként a szervezet rugalmatlansága, a humán erőforrás tudásszintje, kompetenciája, teljesítményre gyakorolt hatása, a munkavállalók lojalitása, valamint a munkaerőpiac korlátai. A tanulmány ezért a vállalkozássikeressége, illetve a vezetőhöz köthető döntések és folyamatok tükrében elemzi a szervezeti innovációt, és a szekunder kutatások eredményeit e szempontok alapján értékeli. A saját primer kutatás újszerű módszertannal a cégvezető és a szervezet közötti GAP-eken keresztül analizálja a KKV-k sikerességét és innovációs attitűdjét.
Journal of Economic Literature (JEL) kód: M14
Application of a Mathematical Model in Determining the Spread of the Rabies Virus: Simulation Study
Authors: Huang Yihao , Li Mingtao 
Published: March 2020

Background
Rabies is an acute infectious disease of the central nervous system caused by the rabies virus. The mortality rate of rabies is almost 100%. For some countries with poor sanitation, the spread of rabies among dogs is very serious.

Objective
The objective of this paper was to study the ecological transmission mode of rabies to make theoretical contributions to the suppression of rabies in China.

Methods
A mathematical model of the transmission mode of rabies was constructed using relevant data from the literature and officially published figures in China. Using this model, we fitted the data of the number of patients with rabies and predicted the future number of patients with rabies. In addition, we studied the effectiveness of different rabies suppression measures.

Results
The results of the study indicated that the number of people infected with rabies will rise in the first stage, and then decrease. The model forecasted that in about 10 years, the number of rabies cases will be controlled within a relatively stable range. According to the prediction results of the model reported in this paper, the number of rabies cases will eventually plateau at approximately 500 people every year. Relatively effective rabies suppression measures include controlling the birth rate of domestic and wild dogs as well as increasing the level of rabies immunity in domestic dogs.

Conclusions
The basic reproductive number of rabies in China is still greater than 1. That is, China currently has insufficient measures to control rabies. The research on the transmission mode of rabies and control measures in this paper can provide theoretical support for rabies control in China.
A un año de gestión en la Escuela Nacional de Enfermería y Obstetricia (ENEO), iniciando el reto: la transformación
Authors: Zárate-Grajales R.A. 
Published: March 2020

La Enfermería es hoy en la UNAM una de las carreras de alta demanda. Esta situación nos obliga a redoblar esfuerzos para responder con calidad educativa a la sociedad que, ve en la Enfermería una excelente opción de vida profesional.
La ENEO es una institución en pleno crecimiento, que tiene un fuerte compromiso social con la nación para formar a profesionales en dos licenciaturas, tanto en la modalidad escolarizada como en línea; ofrece 15 especialidades de posgrado, una maestría en enfermería, un doctorado en proceso de aprobación; así como diversos programas de educación continua. Todos ellos acreditados por los organismos nacionales correspondientes.
CERITA RAKYAT MBAH JAWER SEBAGAI LITERASI SASATRA LOKAL MASYARAKAT PURWAKARTA
Authors: Nina Nina 
Published: March 2020

Kabupaten Purwakarta salah satu kabupaten di Jawa Barat yang memiliki kebudayaan dan sejarah yang menarik. Kabupaten Purwakarta sebagai kota industri mengalami perkembangan yang pesat pada berbagai sektor tak termasuk di bidang pariwisata. Saat ini pemerintah Kabupaten Purwakarta akan resort bertaraf internasional bernama Kampung Air Mbah Jawer di Kecamatan Sukasari Kabupaten Purwakarta. Pemberian nama Mbah Jawer menimbulkan pro dan kontra di kalangan masyarakat karena nama tersebut dianggap mengerikan dan penuh mistis. Bagi masyarakat Kabupaten Purwakarta khususnya di sekitar Waduk Jatiluhur nama Mbah Jawer membuat bulu kuduk berdiri. Cerita rakyat ini berkembang turun menurun dan dipercayai oleh masyarakat tanpa tahu persis kapan dan siapa yang mengetahui awal mula cerita tersebut. Cerita ini berawal dari lahirnya seorang anak yang memiliki jengger (Bahasa Sunda: Jawer) di dahinya mirip jawer ayam. Karena malu orang tua tersebut membuang anak tersebut ke aliran sungai citarum. Sejak peristiwa tersebut masyarakat sekitar mempercayai bahwa Mbah Jawer penguasa Waduk Jatiluhur. Seiring berjalannya waktu nyatanya modernisasi tidak melekangkan mitos Mbah Jawer yang disebut penyebab tenggelamnya orang setiap tahun. Apabila ditelaah lebih lanjut dibalik cerita mistis Mbah Jawer memiliki nilai-nilai positif yang layak dijadikan literasi bahan ajar penguatan pendidikan karakter di sekolah khususnya di Kabupaten Purwakarta. Tujuan penelitian ini untuk mengetahui nilai budaya dari segi nilai sosial dan nilai religious pada cerita rakyat Mbah Jawer di Kabupaten Purwakarta. Teknik pengambilan data yang digunakan adalah teknik wawancara dan dokumentasi. Adapun metode analisis data yang digunakan adalah metode deskriptif kualitatif. Berdasarkan hasil analisis dapat disimpulkan bahwa cerita rakyat Mbah Jawer memiliki nilai
Inibidores da SGLT2 e suas influências no sistema cardiovascular: uma revisão sistemática
Authors: Silva Guilherme Antoneli , Carreira Rodolpho Gareti , Garcia Wendell Felipe , Cavasini Filho Aloísio Eugênio 
Published: March 2020

Objetivo: Descrever, através de uma revisão sistemática, os principais estudos, novidades e influências dos inibidores da Sodium Glucose Cotransporter 2 (SGLT2) no sistema cardiovascular de pacientes diabéticos tipo 2. Métodos: Foram utilizados para pesquisa a base de dados BIREME, considerando textos com os descritores “Inibidores do Transportador 2 de Sódio-Glicose” e “Doenças Cardiovasculares”, publicados entre o período dos anos de 2009-2019, redigidos em inglês, português e espanhol, sendo, posteriormente, avaliados, interpretados e tabulados. Resultados: Inicialmente, 277 artigos foram encontrados na pesquisa, sendo que 192 publicações foram descartadas da avalição por não evidenciarem os critérios de inclusão necessários, tendo sido selecionadas 85 publicações. Destes 85 artigos que contemplaram os critérios de seleção, 38 eram de acesso restrito aos assinantes de seus jornais e os demais 47 foram escolhidos e analisados pelos autores. Considerações finais: Conclui-se que a classe das medicações inibidoras da SGLT2 mostrou-se como opção terapêutica de grande interesse para diabéticos tipo 2, visto sua capacidade de promover inúmeras alterações sistêmicas benéficas nestes pacientes e influenciar diretamente na redução do risco cardiovascular, com redução nas taxas de mortalidade e hospitalização por insuficiência cardíaca.