bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways
Authors: Wan Mao-lin , Wang Yu , Zeng Zhi , Deng Bo , Zhu Bi-sheng , Cao Ting , Li Yu-kun , Xiao Jiao , Han Qi , Wu Qing 
Published: March 2020

Abstract
Colorectal cancer (CRC) is the third most common malignancy and one of the leading causes of cancer-related death among men worldwide. CRC is a multifactor digestive pathology, which is a huge problem faced not only by clinicians but also by researchers. Importantly, a unique feature of CRC is the dysregulation of molecular signaling pathways. To date, a series of reviews have indicated that different signaling pathways are disordered and have potential as therapeutic targets in CRC. Nevertheless, an overview of the function and interaction of multiple signaling pathways in CRC is needed. Therefore, we summarized the pathways, biological functions and important interactions involved in CRC. First, we investigated the involvement of signaling pathways, including Wnt, PI3K/Akt, Hedgehog, ErbB, RHOA, Notch, BMP, Hippo, AMPK, NF-κB, MAPK and JNK. Subsequently, we discussed the biological function of these pathways in pathophysiological aspects of CRC, such as proliferation, apoptosis and metastasis. Finally, we summarized important interactions among these pathways in CRC. We believe that the interaction of these pathways could provide new strategies for the treatment of CRC.
The GAPS Programme at TNG
Authors: Carleo I. , Malavolta L. , Lanza A. F. , Damasso M. , Desidera S. , Borsa F. , Mallonn M. , Pinamonti M. , Gratton R. , Alei E. , Benatti S. , Mancini L. , Maldonado J. , Biazzo K. , Esposito M. , Frustagli G. , González-Álvarez E. , Micela G. , Scandariato G. , Sozzetti A. , Affer L. , Bignamini A. , Bonomo A. S. , Claudi R. , Cosentino R. , Covino E. , Fiorenzano A. F. M. , Giacobbe P. , Harutyunyan A. , Leto G. , Maggio A. , Molinari E. , Nascimbeni V. , Pagano I. , Pedani M. , Piotto G. , Poretti E. , Rainer M. , Redfield S. , Baffa C. , Baruffolo A. , Buchschacher N. , Billotti V. , Cecconi M. , Falcini G. , Fantinel D. , Fini L. , Galli A. , Ghedina A. , Ghinassi F. , Giani E. , Gonzalez C. , Gonzalez M. , Guerra J. , Hernandez Diaz M. , Hernandez N. , Iuzzolino M. , Lodi M. , Oliva E. , Origlia L. , Perez Ventura H. , Puglisi A. , Riverol C. , Riverol L. , San Juan J. , Sanna N. , Scuderi S. , Seemann U. , Sozzi M. , Tozzi A. 
Published: March 2020

Context. The existence of hot Jupiters is still not well understood. Two main channels are thought to be responsible for their current location: a smooth planet migration through the protoplanetary disk or the circularization of an initial highly eccentric orbit by tidal dissipation leading to a strong decrease in the semimajor axis. Different formation scenarios result in different observable effects, such as orbital parameters (obliquity and eccentricity) or frequency of planets at different stellar ages.
Aims. In the context of the GAPS Young Objects project, we are carrying out a radial velocity survey with the aim of searching and characterizing young hot-Jupiter planets. Our purpose is to put constraints on evolutionary models and establish statistical properties, such as the frequency of these planets from a homogeneous sample.
Methods. Since young stars are in general magnetically very active, we performed multi-band (visible and near-infrared) spectroscopy with simultaneous GIANO-B + HARPS-N (GIARPS) observing mode at TNG. This helps in dealing with stellar activity and distinguishing the nature of radial velocity variations: stellar activity will introduce a wavelength-dependent radial velocity amplitude, whereas a Keplerian signal is achromatic. As a pilot study, we present here the cases of two known hot Jupiters orbiting young stars: HD 285507 b and AD Leo b.
Results. Our analysis of simultaneous high-precision GIARPS spectroscopic data confirms the Keplerian nature of the variation in the HD 285507 radial velocities and refines the orbital parameters of the hot Jupiter, obtaining an eccentricity consistent with a circular orbit. Instead, our analysis does not confirm the signal previously attributed to a planet orbiting AD Leo. This demonstrates the power of the multi-band spectroscopic technique when observing active stars.
Finite element modeling of geothermal source of heat pump in long-term operation
Authors: Hałaj Elżbieta 
Published: March 2020

Heat pumps become more and more popular heat source. They can be an alternative choice for obsolete coal fired boilers which are emissive and not ecological. During heat pump installation designing process, especially for heat pumps with higher heating capacity (for example those suppling larger buildings), a simulation of heat balance of ground heat source must be provided.
A 3D heat transport model and groundwater flow in the geothermal heat source for heat pump (GSHP) installation was developed in FEFLOW according to Finite Element Modelling Method. The model consists of 25 borehole heat exchangers, arranged with spacing recommended by heat pump branch guidelines. The model consists of both a homogeneous, non-layered domain and a layered domain, which reflected differences in thermal properties of the ground and hydrogeological factors. The initial temperature distribution in the ground was simulating according to conditions typical for Europe in steady state heat flow. Optimal mesh refinement for nodes around borehole heat exchangers were calculated according to Nillert method.
The aim of this work is to present influence of geological, hydrogeological factors and borehole arrangement in the energy balance and long term sustainability of the ground source. The thermal changes in the subsurface have been determined for a long term operation (30 years of operation period). Some thermal energy storage applications have also been considered.
Retour d’expérience sur la chirurgie robotique en chirurgie orale
Authors: Bénichou L. 
Published: March 2020

Les nouvelles technologies deviennent les véritables stars de la chirurgie de demain ! Entre l’impression 3D, les Big Datas, lintelligence artificielle, et maintenant les robots chirurgicaux le chirurgien vit une période passionnante !
Mais attention à ce que l’utilisation de ces techniques serve à la pratique et ne soit pas la réponse à un simple effet de mode...
«Jai eu la chance de tester le robot chirurgical Da Vinci dans ma pratique de la chirurgie endobuccale... cette présentation est un simple retour dexpérience...»
Ostéonécrose : est-ce une fatalité ?
Authors: Baaroun V. 
Published: March 2020

La question reste en suspens. A limage de nombreuses pathologies, lostéonécrose des mâchoires voit sa littérature senrichir de jour en jour : des publications sur des alternatives de prise en charge évidemment (caisson hyperbare, PRF, cellules souches ...) mais aussi sur déventuels facteurs de risque (durée du traitement, chimiothérapie concomitante ou encore un déficit en vitamine D).
Au regard de cette riche littérature, deux axes semblent se démarquer pour que lostéonécrose ne soit plus une fatalité. Tout dabord la prévention : quel suivi ? Quels examens complémentaires ? Quels foyers infectieux ?
Le second axe de réflexion repose sur la compréhension de sa physiopathologie. Pourquoi les mâchoires ? Pourquoi lIV vs le per os ? Pourquoi certaines thérapeutiques et non d’autres ?
La réponse à ses multiples questions permettrait ainsi que lostéonécrose ne soit plus une fatalité, pour nous et nos patients.
Gestion chirurgicale des défauts osseux verticaux postérieurs
Authors: Maximini G. 
Published: March 2020

L’augmentation de la dimension osseuse verticale est un challenge thérapeutique chirurgical. C’est dans ce domaine que lon compte le plus grand nombre déchecs. La réussite dépend de la prise en compte de deux élément clefs : tout dabord de labsolu nécessité dobtenir un allongement suffisant des lambeaux permettant de suturer sans tension aucune et de contrecarrer ainsi leffet ischémique de la rétraction cicatricielle verticale.
Au maxillaire description et vidéo de lincision vestibulaire d’une hauteur égale à la hauteur du déficit osseux. A la mandibule description et vidéo de lincision crestale avec décollement du lambeau lingual jusquau mylohyoidien et désinsertion du périoste de la ligne oblique interne. Description de la technique de Tinti et Benfenati pour lallongement du lambeau lingual.
Description et vidéo de lincision vestibulaire mandibulaire avec dissection en épaisseur partielle jusquà la crête puis incision du périoste et décollement en épaisseur totale.
Le deuxième élément clef est le choix d’une technique qui privilégie la vascularisation : différentes techniques (greffe on onlay, ROG, split horizontal) seront décrites avec des séquences vidéo et analyse des avantages et des inconvénients.
En résumé : deux maitres mots : gestion des tissus mous et vascularisation.
Evaluation de l’efficacité de l’hypno-sédation par rapport à une anxiolyse pharmacologique sur la qualité de vie et la douleur en post-opératoire de l’avulsion de dents de sagesse sous anesthésie locale : une étude prospective randomisée
Authors: Robardey G. , Smadja A. , Lescaille G. , Bouzouita I. , Descroix V. 
Published: March 2020

Introduction : L’anxiété est associée à une haute intensité de douleur post-opératoire. Les méthodes pharmacologiques anxiolytiques ont prouvé leur efficacité. L’hypnose, qui a montré un bénéfice sur L’anxiété et la douleur per-opératoire et sur le post-interventionnel, est une alternative simple et dénuée d’effets secondaires. Il existe peu de comparaison entre sédation hypnotique et anxiolyse pharmacologique. L’objectif de cette étude est de montrer que L’hypnose est aussi efficace que l’association Hydroxyzine-MEOPA dans la prévention de L’anxiété et de la douleur post-opératoire en chirurgie orale. Matériel et méthodes 30 patients adressés dans le service d’Odontologie de la Pitié Salpêtrière pour avulsion de dents de sagesse homolatérales sous anesthésie locale ont été aléatoirement répartis en 3 groupes de 10 patients : un groupe bénéficiant de l’association Hydroxyzine-MEOPA, le second d’une hypno-sédation et le troisième était le groupe contrôle. Le protocole chirurgical était standardisé et les prescriptions post¬opératoires identiques. La chirurgie était réalisée par un opérateur et un hypnothérapeute uniques. Le critère principal de jugement était la qualité de vie post-opératoire. Un questionnaire évaluant par 17 items le dysfonctionnement, le malaise et le handicap oraux (score OHIP : 0 à 80 de la meilleure qualité de vie à la plus dégradée) était rempli par le patient à H0, H6, J, J2, J3, J7 et remis lors de la consultation de contrôle à J7. Les critères secondaires évaluaient la quantit 1 d’anesthésie per- opératoire, la durée opératoire, la douleur et L’anxiété post-opératoire et la durée de consommation d’antalgiques. Discussion L’étude poursuit l’inclusion de patients. Les résultats préliminaires sur 30 patients comparant les groupes Hydroxyzine-MEOPA et hypnose au groupe contrôle montrent une qualité de vie post-opératoire significativement meilleure dans le groupe hypnose à H6 (44.3[25.4-63.2] vs. 61.4[37.4-85.4], p=0.0048), J1 (p=0.0034), J2 (p=0.0037), J3 (p=0.0005), J7 (p=0.0003). La douleur y est également significativement plus faible dès J1 (EVA 4.3[1.8-6.8] vs. 6.8[3.9-9.7], p=0.0021), tout comme la quantité d’anesthésique per-opératoire (3.4[2.9-3.9] cartouches vs. 4.1[3.8-4.4], p=0.001), la durée d–intervention (49[44-54] minutes vs. 61[53-69], p=0.0008) et la durée de prise d’antalgiques post- opératoire (3.6[2.9-3.3] jours vs. 4.4[4.2-4.6], p=0.005).
Conclusion : L’hypno-sédation semble être une méthode de gestion de L’anxiété au moins aussi efficace que l’association Hydroxyzine-MEOPA pour l’avulsion des dents de sagesse. Son effet protecteur sur le post-opératoire est un réel bénéfice pour le patient : réduction de la quantité d’anesthésie et du temps opératoire, diminution de la douleur post- opératoire et de la durée de prise d’antalgiques.
Utilisation combinée des biomatériaux xénogéniques et d’os autologue en chirurgie reconstructrice préimplantaire : Réflexions à propos de quatre indications méconnues
Authors: Gellee T. , Philippe B. 
Published: March 2020

Introduction : Les comblements sous-sinusiens et les ROG représentent les indications principales des biomatériaux de substitution xénogénique en Chirurgie Reconstructrice Pré-Implantaire. D’autres indications moins répandues nous paraissent devoir être présentées, en particulier la prévention de la résorption centripète et l’harmonisation des contours squelettiques des greffes d’apposition d’os autologue, les coffrages et les comblements étendus ainsi que la gestion des résorptions tardives de certaines greffes d’appositions. L’objectif de cette communication consiste à présenter ces situations cliniques rarement décrites mais dont la prise en charge raisonnée mérite d’être connue afin de mieux répondre aux besoins des patients. Matériel et méthode : Cinq dossiers représentatifs de ces indications sont exposés. Les problématiques rencontrées, les moyens mis en œuvre comme les résultats cliniques et radiographiques sont abordés. Discussion : Les cas étudiés illustrent les raisons pour lesquelles l’utilisation conjointe des biomatériaux xénogènes et de l’os autogène trouve son indication. L’Os xénogénique ostéo-conducteur participe au maintien des volumes et à lobtention d’une densité é levée au sein des reconstructions. L’Os autogène ostéo-conducteur, ostéo- inducteur et ostéogénique permet dans sa forme massive la réalisation de reconstructions bi ou tridimensionnelles étendues. Les membranes xénogéniques permettent de maintenir l’équilibre dans la compétition de l’intégration entre les tissus durs et les tissus mous. L’adjonction de concentrés plaquettaires prélevés en phase liquide et mélangés à la thrombine activée assure si nécessaire l’aggrégation des granules calcifiés d’os xénogénique. Conclusion : L’utilisation combinée des biomatériaux de substitution xénogéniques avec l’os autogène constitue une aide significative dans la prise en charge de certaines reconstructions pré-implantaires complexes. La stabilité des reconstructions dans leur forme et dans le temps comme l’augmentation de la densité offerte aux implants constituent les principaux avantages attendus.
Liens dintérêt : Aucun
Full Agonist Opioid Prescribing by Primary Care Clinicians after Buprenorphine Training
Authors: Gadomski Anne , Anderson James , Chung Yelim K. , Krupa Nicole , Jenkins Paul 
Published: March 2020

Background While primary care clinicians are being trained to use buprenorphine for the treatment of Opioid Use Disorder (OUD) in order to increase access to addiction treatment, it is not known what impact such training and subsequent experience treating patients with OUD has on full agonist opioid prescribing. Methods This retrospective cohort study compares the full agonist opioid prescribing patterns of Drug Addiction Treatment Act (DATA)-waivered (“X-waivered”) primary care clinicians to non-trained, non-waivered clinicians in a rural health network. X-waivered clinicians also received Project ECHO training and telementoring support for one year. Using prescriber data generated by an electronic medical record system, opioid prescribing and morphine milligram equivalents (MME) per day per patient were calculated. A between-group analysis was used to compare the study groups six months pre-versus post-training. Results Although the mean number of full agonist opioid prescriptions per clinician and per 100 patient encounters decreased among all clinicians, there was no change in full agonist opioid prescribing MME. As expected, buprenorphine prescribing by X-waivered, trained clinicians increased significantly post-training. Conclusions X-waivers plus Project ECHO support for the treatment of OUD using buprenorphine had no effect on full agonist opioid prescribing by primary care clinicians.
From Transcript to “Trans-Script”: Romanized Santali across Semiotic Media
Authors: Choksi Nishaant 
Published: March 2020

AbstractSantali is an Austro-Asiatic language spoken throughout eastern India, Nepal, and Bangladesh. It is currently written in multiple scripts, including a Roman script devised by missionaries in the late nineteenth century, various Indic scripts, and an independently derived script, Ol-Chiki. Each of these script systems entails different sound-to-script relationships, especially for phones such as the word-final glottalized consonants, which are not present in the dominant Indo-European vernaculars. This article traces the historical transformations of sound-to-script relations in the various scripts of Santali and tracks in particular a Romanized Santali transcription orthography that developed as a way to mediate between different scripts. The Romanized Santali form assumed a particular importance as Santali speakers started using Santali in digital and online spaces due to software limitations. However, the differing use of variants within the script to represent sounds such as word-final glottal consonants shows that what appears to be a novel orthography is in fact a “trans-script,” rhematizing the historical and ideological trajectories of the various script systems already in use in nondigital domains. The article claims that the Romanized “trans-script,” though internally diverse, has been deployed to further the standardization project and cultural politics associated with the Ol-Chiki script.
Comparative studies of variation in end mill radial rake angle and cutting conditions on cutting force and surface integrity during machining of nimonic 263
Authors: Gowthaman S , Jagadeesha T 
Published: March 2020

Abstract
Tool nomenclature has a profound effect on the machining of alloys and the cutting force during machining. In this study, the effect of changes in radial rake angle of end mill cutter (+7°,0°, −7°) and machining parameters such as spindle rotational velocity (v) and table feed velocity ( f ) on cutting force and surface roughness were presented using regression analysis and a comparison has been made with the measured surface roughness and cutting force data. Additionally, to confirm the goodness of fit, Analysis of variance (ANOVA) has been undertaken and found that the developed empirical model is significant. The experimental outcome clearly indicates that the radial rake angle of end mill cutter is the most significant parameter, which reflect higher efficiency during machining followed by table feed velocity. Spindle rotational velocity is found to be a least significant parameter. Furthermore, the analysis of chip morphology confirmed the behavioral changes while machining due to the presence of variation in tool nomenclature and machining condition.
The role of signaling constraints in defining optimal marginal costs of reliable signals
Authors: Harris Keith D , Daon Yair , Nanjundiah Vidyanand 
Published: March 2020

AbstractThe handicap principle was originally proposed to resolve the question of why, in their competition for mates, certain species invest in exaggerated ornaments that are often detrimental to their survival. Zahavi suggested that the traits that are most suitable to serve as signals are precisely those that require the burden of extra investment to increase in magnitude: that burden enables the signal to be correlated with the signaler’s quality. According to his model, the additional investment in signaling results in a functional advantage. It does so by providing more accurate information regarding the signaler as it increases the distinction between males of similar quality. There are a number of formalizations of this model, and experimental studies of the handicap principle have focused on testing them. Nonetheless, there is little consensus whether 1) ensuring reliability requires an additional investment or 2) traits that require a relatively higher investment to increase (have higher marginal costs) are selected as signals over those with lower marginal costs. Here, we present an agent-based mate choice model that quantifies the relative stability of signals with different marginal costs. Our model demonstrates how quality-independent constraints (in signal production and perception) affect the range of marginal costs for which a signal is informative. In turn, receiver preference for informative signals drives the selection of signals according to marginal cost. The presence or absence of signaling constraints can determine the outcome of costly signaling models and, thus, explain the different conclusions of Zahavi’s verbal model and its subsequent formalizations.
forgeNet: a graph deep neural network model using tree-based ensemble classifiers for feature graph construction
Authors: Kong Yunchuan , Yu Tianwei 
Published: March 2020

AbstractMotivationA unique challenge in predictive model building for omics data has been the small number of samples (n) versus the large amount of features (p). This ‘n≪p’ property brings difficulties for disease outcome classification using deep learning techniques. Sparse learning by incorporating known functional relationships between the biological units, such as the graph-embedded deep feedforward network (GEDFN) model, has been a solution to this issue. However, such methods require an existing feature graph, and potential mis-specification of the feature graph can be harmful on classification and feature selection.ResultsTo address this limitation and develop a robust classification model without relying on external knowledge, we propose a forest graph-embedded deep feedforward network (forgeNet) model, to integrate the GEDFN architecture with a forest feature graph extractor, so that the feature graph can be learned in a supervised manner and specifically constructed for a given prediction task. To validate the method’s capability, we experimented the forgeNet model with both synthetic and real datasets. The resulting high classification accuracy suggests that the method is a valuable addition to sparse deep learning models for omics data.Availability and implementationThe method is available at https://github.com/yunchuankong/forgeNet.Contacttianwei.yu@emory.eduSupplementary informationSupplementary data are available at Bioinformatics online.
Spatially Dissociated Intracerebral Maps for Face- and House-Selective Activity in the Human Ventral Occipito-Temporal Cortex
Authors: Hagen Simen , Jacques Corentin , Maillard Louis , Colnat-Coulbois Sophie , Rossion Bruno , Jonas Jacques 
Published: March 2020

AbstractWe report a comprehensive mapping of the human ventral occipito-temporal cortex (VOTC) for selective responses to frequency-tagged faces or landmarks (houses) presented in rapid periodic trains of objects, with intracerebral recordings in a large sample (N = 75). Face-selective contacts are three times more numerous than house-selective contacts and show a larger amplitude, with a right hemisphere advantage for faces. Most importantly, these category-selective contacts are spatially dissociated along the lateral-to-medial VOTC axis, respectively, consistent with neuroimaging evidence. At the minority of “overlap” contacts responding selectively to both faces and houses, response amplitude to the two categories is not correlated, suggesting a contribution of distinct populations of neurons responding selectively to each category. The medio-lateral dissociation also extends into the underexplored anterior temporal lobe (ATL). In this region, a relatively high number of intracerebral recording contacts show category-exclusive responses (i.e., without any response to baseline visual objects) to faces but rarely to houses, in line with the proposed role of this region in processing people-related semantic information. Altogether, these observations shed novel insight on the neural basis of human visual recognition and strengthen the validity of the frequency-tagging approach coupled with intracerebral recordings in epileptic patients to understand human brain function.