bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Health-related Factors Influencing Fears of Aging among Elderly Chinese Citizens
Authors: Tien Yun-Hsiang , Huang Jingchi 
Published: December 2024

Summary
Many countries face an increasingly aging population, but China is now home to the largest population of older people in the world. This study aims to analyze health-related factors influencing fears of aging among elderly Chinese citizens. Multiple regression models were constructed using fears of aging as the dependent variable and demographics and other key components as independent variables, respectively. Results showed that individuals with a chronic disease had more fears of aging than those without a chronic disease. Individuals with a higher personal annual income had less fears of aging. Individuals who were less worried about the lack of timely treatment and unaffordable medical expenses had less fears of aging.
Association between Type 2 Diabetes Mellitus and Risk of Development of Oral Cancer: A Systematic Review and Meta-analysis
Authors: Kabra Anagha , Shaw Amar Kumar , Kanjalkar Sakshi , Panchal Aditi , Sahoo Pradyumna Kumar , Gachake Arti 
Published: December 2024

ABSTRACT

Aim:
To assess the risk of developing oral cancer (OC) in individuals who have diabetes mellitus (DM) and to predict the prognosis for OC patients with DM.

Methodology:
The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines and was registered in PROSPERO (CRD42024517197). A thorough search of databases was conducted from January 2000 to May 2024 to identify studies reporting the reporting association between DM and the development of OC. Quality assessment was performed using the Newcastle Ottawa Scale for included studies. The odds ratio (OR) and risk ratio (RR) served as the summary statistic measure, employing a random-effect model with a significance threshold set at P < 0.05.

Results:
Twelve studies met the eligibility criteria and underwent qualitative synthesis, with eight studies in meta-analysis. Upon quality assessment, the studies demonstrated a range of moderate to low risk of bias (ROB), ensuring a comprehensive evaluation of the evidence base. Meta-analysis showed that individuals with type 2 diabetes mellitus had a higher shown high association (OR = 2.07 (0.52–8.18) and risk (RR =1.31 (0.70–2.43) for the development of OC compared to nondiabetics (P > 0.05). The funnel plot did show presence of possible publication bias in meta-analysis.

Conclusion:
It was found that DM patients were at higher risk and more associated with the development of OC. However, as OC is multifactorial disease, the presence of a single factor cannot have a significant effect on disease progression. Therefore, furthermore prospective studies with a greater sample size and follow-up period should be conducted so as to validate the findings of this study.
Comparative Evaluation of Effectiveness of Demineralized Freeze-dried Bone Allograft and Other Regenerative Materials for the Treatment of Intrabony Periodontal Defects: A Systematic Review and Meta-analysis
Authors: Ghike Mayuri Rajiv , Phadnaik Mangesh Bhalchandra , Karemore Vaibhav , Desurkar Yugandhara Rameshsingh 
Published: December 2024

ABSTRACT
The aim of this systematic review and meta-analysis is to evaluate and compare the effectiveness of demineralized freeze-dried bone allograft (DFDBA) and other regenerative materials for the treatment of intrabony periodontal defects. Randomized controlled trials (RCTs) and non-randomized controlled trials (Non-RCTs) reporting on clinical and/or radiographic outcome parameters of periodontal regenerative procedures OF DFDBA with other regenerative materials with a follow-up of more than 3 months were systematically assessed. PRISMA checklist was followed and electronic and hand search was done to identify the studies. Outcome variables were pocket probing depth and pocket depth reduction (PDR), clinical attachment level and clinical attachment gain (CAG), gingival recession (GR), bone fill and percentage (%) of bone fill. Meta-analysis was carried out with possible RCT studies using the DerSimonian–Laird estimator of variance. As sensitivity analysis, fixed-effect meta-analysis was performed using the Mantel–Haenszel method. The search resulted in 1235 published studies. After removal of duplicates and full-text analysis, 10 RCTs and 4 non-RCTs were selected. Overall, the result demonstrated the promising regenerative capacity of DFDBA with other graft materials for the treatment of intabony periodontal defect. Within the limitations of the present systematic review and meta-analysis, the use of DFDBA gives better results in terms of PDR, GR, bone fill, and percentage of bone fill when compared to other regenerative materials in treatment of intrabony periodontal defects, except CAG.
Oral Manifestations in Organ Transplant Patients: A Literature Review
Authors: Muñoz-Gallardo Willy , Espinoza-Carhuancho Fran , Medina Julia , Quispe-Tasayco Lucia , Mauricio-Vilchez Cesar , Galarza-Valencia Diego , Mayta-Tovalino Frank 
Published: December 2024

ABSTRACT
To examine oral manifestations in organ transplant patients, with a focus on viral infections, fungal infections, neoplastic diseases, and inflammatory diseases. A literature review study was conducted. A search was conducted on February 5, 2024, in Scopus and PubMed, using the keywords related to oral manifestations and organ transplantation. We included articles on solid organ or hematopoietic transplantation, which were published in English or Spanish. We excluded the articles focused on specific populations or without full text. Relevant articles were selected based on a review of the title, abstract, and full text. Viral infections, such as cytomegalovirus and Epstein–Barr virus infections were commonly reported in transplant recipients, with studies highlighting the importance of monitoring and management. Fungal infections, particularly candidiasis, were reported to also be prevalent, emphasizing the need for improved dental care and screening. Neoplastic disease, specifically oral cancer, was a significant concern, with factors, such as immunosuppressive therapy and previous skin cancer, increasing the risk. Inflammatory diseases, such as oral mucositis, were common after transplantation, and they require supportive measures for management. Despite variations in reported incidences, studies underscored the importance of dental and periodontal care in transplant patients. Both healthy individuals and transplant recipients require comprehensive oral health care to prevent discomfort and disease. However, no definitive conclusions can be drawn owing to the study’s limitations. Thus, further research is needed in this area. This study highlights the prevalence of oral manifestations such as viral and fungal infections, oral cancer and inflammatory diseases in transplant patients. It underlines the need for comprehensive dental care and further research to improve the quality of life of these patients, despite the limitations of the study.
Nonexpandable Lung
Authors: Chandran Arjun 
Published: December 2024

Abstract
Nonexpandable lung can be due to entrapment or trapped lung. Both conditions have distinct pathophysiology and management strategies. In this review, we discuss each condition with emphasis on causes, pathophysiology, and various investigations in diagnosis. Special emphasis on the role of pleural manometry is also included. The management strategies of both entrapment and trapped lung are also highlighted in this review.
COVID-19 treatment: Nattokinase, a fibrinolytic serine protease is the low-hanging fruit
Authors: Okeahialam Basil Nwaneri 
Published: December 2024

ABSTRACT
COVID-19 infection was first reported in 2019 and was shortly declared a pandemic. Without ample time for targeted research into therapy, various existing drugs were tried with limited success and vaccines speedily emerged. Although with serious consequences in some instances, vaccination brought relief as a public health measure. Before long, breakthrough infections were recorded postvaccination and protection waned with time. With new cases still being recorded, it has become necessary to try more agents with the potential for therapeutic benefits. In viral infections, it is the immune consequences that kill and not the viruses. Therefore in treatment, it is either the body is protected from the infection or the immune consequences. The phase of infection is preclinical and may go unnoticed. Once symptoms appear it is the immune consequences that the body is left to grapple with. That may be why antiviral agents when symptoms appear is too little too late. Victims of COVID-19 infection die from the perturbation of the clotting and fibrinolytic pathways resulting in ineffective oxygenation of the tissues from extensive microthrombi. Therefore, anything that would lyse the microthrombi and allow tissue perfusion should hold the aces. This is where Nattokinase, a fibrinolytic serine protease comes in. It counters Plasminogen Activator Inhibitor-1 which levels mirror disease severity and gives tissue plasminogen activator freedom to lyse the fibrin that clogs the vasculature. This is at the center of the disease pathophysiology and saves the infected individual.
From casinos to clicks: The evolution of gambling in the digital age
Authors: Saran Brijesh 
Published: December 2024

ABSTRACT

Introduction:
The emergence of the Internet has revolutionized gaming into a multibillion-dollar global enterprise, referred to as online gambling or iGaming. This article examines the historical context and technology innovations that have driven this growth, with particular emphasis on the psychological variables and design components that may contribute to obsessive behaviors.

Objective:
The principal objective of this study is to examine the influence of technical design on user behavior in online gambling, determining how these characteristics may encourage excessive usage and addiction. It aims to comprehend the wider ramifications of online gambling on society.

Methods:
The essay analyzes the current literature on Internet gambling, focusing on different modalities such as sports betting, online casinos, and poker. It classifies the design attributes of online platforms and evaluates their impact on user engagement and control.

Results:
Research demonstrates that technology innovations, such as mobile gaming and blockchain, have markedly improved user experience and accessibility. Nonetheless, these characteristics may also lead to addiction, as more than 60% of individuals with gambling problems suffer from concomitant psychiatric conditions.

Conclusion:
The Internet gaming sector persists in its evolution, offering both prospects and obstacles. Although it yields significant economic advantages, the risk of addiction requires an emphasis on ethical gaming practices and regulatory frameworks to safeguard consumers and encourage better engagements with technology.
Emerging medications in psychiatry: Transforming the treatment landscape for depression and psychosis in Parkinson’s disease
Authors: Saran Brijesh , Bhagat Tripta S. , Bhagat Rohit 
Published: December 2024

ABSTRACT

Introduction:
The article reviews recent advancements in psychiatric medications for schizophrenia and depression, highlighting esketamine, and pimavanserin. It discusses their development, mechanisms, clinical efficacy, safety profiles, and future research directions, emphasizing their transformative potential and new hope for patients.

Objective:
The objective of this article is to review recent advancements in psychiatric medications for schizophrenia and depression, focusing on the development, pharmacological properties, clinical efficacy, safety profiles, and future directions of emerging drugs, highlighting their potential to transform treatment and improve patient outcomes.

Methods:
The article reviews emerging psychiatric medications, detailing their pharmacological properties, clinical efficacy, and safety profiles. It includes esketamine for treatment-resistant depression and pimavaenserin for psychosis symptoms in Parkinson’s diseases. Each drug’s mechanism of action, clinical trial results, and potential future research directions are discussed.

Results:
The article highlights the efficacy and safety of emerging psychiatric medications, including esketamine for treatment-resistant depression and pimavaenserin for psychosis symptoms in Parkinson’s diseases. Clinical trials demonstrate significant symptom reduction and improved patient outcomes, with ongoing research exploring further applications and optimization of these treatments.

Conclusion:
Emerging psychiatric medications such as esketamine and pimavenserin offer significant advancements in treating conditions such as treatment-resistant depression, postpartum depression, and schizophrenia. These drugs provide rapid and sustained symptom relief, with ongoing research aimed at optimizing their use and exploring new therapeutic applications.
From symptoms to solutions: Addressing major depressive episodes in a multiple sclerosis patient
Authors: Saran Brijesh , Bhagat Tripta S. , Bhagat Rohit 
Published: December 2024

ABSTRACT
Multiple Sclerosis (MS) is a chronic autoimmune disease that causes demyelination in the central nervous system, leading to significant physical and cognitive impairments. Depression is a common comorbidity in MS patients, further complicating their treatment and negatively affecting their quality of life. This study aimed to examine the impact of comorbid depression on medication adherence and clinical outcomes in MS patients, emphasizing the need for integrated psychiatric care. A detailed evaluation was conducted on an MS patient presenting symptoms of depression. This included a full psychiatric assessment, laboratory tests to rule out other medical conditions, and neuroimaging to confirm the MS diagnosis. The patient showed severe symptoms of depression, including psychomotor retardation, weight loss, and sleep disturbances. After starting treatment with escitalopram, the patient showed significant improvement in depressive symptoms within one month, highlighting the effectiveness of tailored psychiatric interventions in managing depression in MS patients.
Knowledge of vertical bracket positioning in orthodontics: A survey among orthodontists in India
Authors: Garje Komal Bibhishan , Ahluwalia Rajiv , Chugh Tina , Rajput Shambhavi 
Published: December 2024

ABSTRACT

Introduction:
Orthodontic treatment has increasingly focused on enhancing facial esthetics, combined with smile design playing a crucial role in patient satisfaction. The smile arc, a natural curvature of the upper incisors relative to the lower lip during a smile, is central to creating facial harmony.

Aim:
This study examines orthodontists’ awareness and utilization of various vertical bracket positioning techniques, including smile arc protection (SAP) and the Systematic Anterior and Mesiodistal Reference Approach (SAMRA) combined approach, to maintain smile esthetics during treatment.

Methodology:
A total of 89 orthodontists participated in this study, comprising 50 males and 39 females. A semi-structured questionnaire was distributed via Google Forms to assess their knowledge, practices, and opinions on bracket positioning. Key areas included bracket positioning techniques, use of diagnostic tools, and familiarity with techniques middle facial axis point, MBT, SAP, and SAMRA.

Results:
The survey revealed that while 75% of orthodontists were aware of SAP, only a small proportion (4.6%) used it consistently, with 41% using it rarely. Similarly, 52.6% of orthodontists were aware of the SAMRA approach, but only a few of orthodontists employed it regularly. Most orthodontists (44.6%) used a single bracket positioning technique across all cases, while 51.8% of orthodontists relied on visual examination rather than diagnostic tools like orthopantomograms (OPGs). MBT was the most popular technique, favored by 69.9% of respondents.

Conclusion:
While some orthodontists are aware of newer techniques, not many actively practice them. This highlights the need for greater awareness and education to help practitioners confidently adopt these advanced methods.
PENGARUH DISIPLIN, MOTIVASI DAN KUALITAS TERHADAP KINERJA PEGAWAI DINAS PERINDUSTRIAN PERDAGANGAN ENERGI DAN SUMBER DAYA MINERAL PROVINSI SUMATERA UTARA
Authors: Maysarah Siti , Sari Tika Nirmala 
Published: December 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Disiplin Kerja, Motivasi Kerja Dan Kualitas Kerja Terhadap Kinerja Pegawai Pada Dinas Perindustrian Perdagangan Energi Dan Sumber Daya Mineral Provinsi Sumatera Utara. Metode penelitian ini adalah kuantitatif dengan menggunakan pendekatan assosiatif. Teknik pengambilan sampel menggunakan metode slovin dengan jumlah sample sebanyak 60 responden. Teknik pengumpulan data dilakukan dengan wawancara, observasi dan kuesioner. Berdasarkan hasil penelitian secara parsial bahwa variabel disiplin kerja berpengaruh positif dan signifikan terhadap kinerja pegawai, motivasi kerja berpengaruh positif dan signifikan terhadap kinerja pegawai dan kualitas kerja berpengaruh positif dan signifikan terhadap kinerja pegawai Pada Dinas Perindustrian Perdagangan Energi Dan Sumber Daya Mineral Provinsi Sumatera Utara. Dan secara simultan menunjukan bahwa variabel disiplin kerja, motivasi kerja dan kualitas kerja berpengaruh positif dan signifikan terhadap kinerja pegawai.Kata Kunci: Disiplin Kerja, Motivasi Kerja, Kualitas Kerja dan Kinerja Pegawai
Metabolomics analysis of rat blood in atherosclerosis modelling
Authors: Unesikhina Maria S. , Chemezov Aleksei I. , Sutunkova Marina P. , Minigalieva Ilzira A. , Kungurtseva Alexandra K. 
Published: December 2024

Introduction. Atherosclerotic changes in blood vessels are one of the main causes of death from cardiovascular diseases worldwide. The use of modern approaches to the study of the disease giving a more detailed description of its pathophysiology may open up additional opportunities for prevention, diagnosis, and treatment. Metabolomics is one of such approaches allows obtaining information on a large number of compounds, the combination of which reflects ongoing metabolic changes. The data presented in this article supplement our previously published study results.
The study aimed to find the relationship between the thickness of the wall of the thoracic aorta in animals on a hyperlipidemic diet and the content of metabolites in the blood.
Materials and methods. The study involved thirty male albino Wistar rats. Atherosclerosis was modelled using a diet consisting of standard feed, simple sugars and fats with the addition of vitamin D3 and Thiamazole. Liquid chromatography with tandem mass spectrometry was used for the metabolomics blood test. Histological sections of rat thoracic aortas were stained with hematoxylin and eosin for the analysis.
Results. Histopathological examination of the thoracic aorta in the animals fed with the atherogenic diet revealed morphological signs of atherosclerosis with severe calcification of the vascular wall. The wall of the thoracic aorta in cases (2.61 ± 0.05 µm) was statistically thicker than in the controls (1.82 ± 0.01 µm) (p < 0.001). Correlation analysis revealed significant negative relationships between thoracic aortic wall thickness and arginine, indole and three of its derivatives, and ketodeoxycholic acid, and positive relationships with glutamate, ophthalmic acid, adenosine diphosphate, two long-chain acylcarnitines, glycocholic acid, oxidized fatty acid, and six lysoglycerophospholipids.
Limitations. The study included only Wistar rats with a limited number of rodents per group.
Conclusion. The relationship between metabolomic alterations in blood and thickness of the wall of the rat thoracic aorta indicates metabolic restructuring typical for atherosclerosis, resulting from oxidative stress, an ongoing inflammatory response, and lipid metabolism disorders characterized by severe calcification, endothelial dysfunction, and increased thrombosis.
Инновационное развитие системы управления предприятием в условиях цифровой трансформации
Authors: Пальмов С.В. , Мкртчян М.С. , Сагдеева Л.Ф. 
Published: December 2024

В статье рассматриваются особенности инновационного развития системы управления предприятием в условиях цифровой трансформации современной экономики. Современные тенденции цифровой трансформации существенно влияют на систему управления предприятием, требуя ее инновационного развития. Переход к цифровой экономике характеризуется внедрением передовых технологий, оптимизацией бизнес-процессов, изменением организационных структур и методов принятия управленческих решений. В этих условиях возникает необходимость совершенствования системы управления предприятием, ориентированной на повышение эффективности, гибкости и адаптивности к динамично меняющимся внешним условиям.
Contemporary trends in digital transformation significantly impact enterprise management systems, necessitating their innovative development. The shift toward a digital economy is marked by the integration of advanced technologies, optimization of business processes, and changes in organizational structures and decision-making methods. Under these circumstances, there is a growing need to enhance enterprise management systems to improve efficiency, flexibility, and adaptability to rapidly changing external conditions. This article explores the characteristics of innovative development in enterprise management systems within the context of the digital transformation of the modern economy.
Финансовый анализ в процессах аудита результатов деятельности организаций: развитие методики
Authors: Чернова С.А. 
Published: December 2024

Вопросы эффективного управления связаны с оптимальным взаимодействием управленческих функций, среди которых анализ и аудит, так как, в конечном счете, цель у этих функций одна – повышение эффективности организации в целом и степени доверия партнеров. Какой же функционал отводится каждой из них и где границы и водораздел аудита и анализа? Или, напротив, поле их взаимодействия и сотрудничества? Ответы на вопросы представлены в статье. Кроме того, апробирована методика финансового анализа важнейших результатов деятельности АО «Газпром газораспределение Махачкала».
The issues of effective management are related to the optimal interaction of management functions, including analysis and audit, since, ultimately, these functions have one goal – to increase the efficiency of the organization as a whole and the degree of trust of partners. What functionality is assigned to each of them and where are the boundaries and watershed of audit and analysis? Or, on the contrary, the field of their interaction and cooperation? The answers to the questions are presented in the article. In addition, the methodology for financial analysis of the most important results of the activities of Gazprom Gazoraspredelenie Makhachkala JSC has been tested
Variabilidad de la comunidad de poliquetos en un periodo de 24 años en la playa El Agallito, península de Azuero, Panamá
Authors: Samaniego Cinthia , Gómez Juan Antonio , Goti Italo 
Published: December 2024

Los poliquetos como componentes básicos de la red trófica bentónica marina, ingenieros del ecosistema, indicadores de contaminación ambiental, además del generalizado uso en proyectos acuícolas animan al estudio de la variabilidad de estos grupos en el tiempo. Para determinar posibles cambios de la población de poliquetos en la playa El Agallito, Panamá, se realizó la comparación de la densidad, diversidad y estructura de la población entre los meses de marzo y julio de los años 1997, 1999 y 2021, mediante muestras tomadas en tres estaciones, con nucleador de 17 cm de diámetro, introducidos 15 cm en el sedimento. La curva de rarefacción fue mayor en 1997, la densidad fluctuó entre 1 423,02 ind/m2 y 5 773,95 ind/m2 durante el estudio. Las diferencias entre períodos no se relacionan con la granulometría, ni con la amplitud de la marea, sin embargo, se muestran variaciones ante los fenómenos de El Niño y La Niña y la intensidad de estos.