bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in heart failure patients undergoing hybrid comprehensive telerehabilitation versus usual care – results of the Telerehabilitation in Heart Failure Patients (TELEREH-HF) Randomized Clinical Trial
Authors: Piotrowicz Ewa , Mierzyńska Anna , Banach Maciej , Jaworska Izabela , Pencina Michał , Kowalik Ilona , Pluta Sławomir , Szalewska Dominika , Opolski Grzegorz , Zaręba Wojciech , Glowczynska Renata , Irzmański Robert , Orzechowski Piotr , Kalarus Zbigniew , Piotrowicz Ryszard 
Published: September 2020

IntroductionHybrid comprehensive telerehabilitation (HCTR) consisting of telecare (with psychological telesupport), telerehabilitation and remote monitoring of implantable devices might be an innovative option improving heart failure (HF) patients’ quality of life (QoL) and emotional health. The aim of the study was to investigate the influence of HCTR on various facets of QoL in HF patients in comparison with usual care (UC) alone.Material and methodsThe present analysis formed part of a multicenter, randomized trial that enrolled 850 HF patients (NYHA I–III, LVEF ≤ 40%). Patients were randomized 1 : 1 to HCTR plus UC or UC only. Patients underwent either an HCTR program or UC with observation. The psychological intervention in the HCTR group included supportive psychological counseling via mobile phone. The Medical Outcome Survey Short Form 36 Questionnaire was used to assess QoL. Measurements were made before and after a 9-week intervention (HCTR group)/observation (UC group).ResultsAfter the intervention, the HCTR group showed significant improvement in overall QoL, physical domain (PD) of QoL, and 4 areas of QoL (physical functioning (PhF), role functioning related to physical state (RF), general health (GH), vitality (VI)). A significant positive change in QoL in the UC group was observed only in VI and social functioning. There were also significant differences in QoL after 9-week intervention/observation between the two groups. The results showed greater improvement in HCTR for overall QoL (p = 0.009), PD of QoL (p = 0.0003) and three specific areas of QoL: PhF (p = 0.001), RF (p = 0.003), bodily pain (BP) (p = 0.015).ConclusionsIn comparison to UC, HCTR resulted in improvement in overall QoL, PD of QoL and 3 specific areas of QoL: PhF, RF and BP.
Significant COVID-19 burden in Polish children
Authors: Jackowska Teresa , Wrotek August , Jankowski Mateusz , Pinkas Jarosław 
Published: September 2020

IntroductionCOVID-19 cases have rarely been reported in children. We sought to analyse the attack rate in paediatric population in Poland, focusing on local variations among the provinces, correlation with the number of tests per capita, and test positivity rate.Material and methodsThis cross-sectional study involved the 38.38 million population and detected 17,921 cases (age known in 17,822). Data were collected from publicly available registries and were analysed by age group and province of the country.ResultsChildren constituted 6.68% of cases (n = 1,191). The attack rate reached 15.49/100,000 children, increasing with age (10.79/100,000 in < 4 y.o. to 21.59/100,000 in 15–19 y.o.). Significant variations in the attack rates were observed: a 9.52-fold ratio between the highest and the lowest attack rates in provinces. The provinces from the first and fourth attack rate quartiles differed in the test positivity rate (4.96% vs. 1.98%, p < 0.05), but not in the number of tests per capita. The lowest quartile provinces showed 1.87- to 5.78-fold lower attack rates, compared to the directly neighbouring provinces, without any known population susceptibility differences. The attack rates in children and adults correlated very strongly (rho = 0.81). The attack rate correlated with the test positivity rate (rho = 0.64 in children and rho = 0.71 in adults) but not with the number of tests per capita.ConclusionsCOVID-19 burden in children is significant. The local differences highlight various testing strategies, but the awareness of SARS-CoV-2 in children is essential. The correlation between attack rates in children and adults shows that the outbreak in children is parallel to the one observed in adults.
The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility
Authors: Oner Gokalp , Ciftci Banu , Turktekin Nurettin , Tas Mustafa , Ulug Pasa , Kumtepe Yakup 
Published: September 2020

IntroductionThis prospective randomized controlled trial aimed to evaluate the effect of intrauterine insemination (IUI) before frozen-thawed elective single embryo transfer (FT-eSET).Material and methodsA total of 200 couples with unexplained subfertility underwent in-vitro fertilization (IVF) treatment. Patients were randomly assigned to either FT-eSET or IUI preceding FT-eSET. Both groups were composed of 100 women. IUI was timed 6 days before FT-eSET in the IUI preceding FT-eSET group. Implantation rates (IR), biochemical and clinical abortion rates (AR), clinical pregnancy rates (PR), ongoing pregnancy rates (PRs), and live birth rates were measured in this study.ResultsThe IUI preceding FT-eSET group was associated with higher rates of clinical pregnancy, 54% vs. 42%, but not significantly. Similarly, IR, PR and live birth rate were higher in the IUI preceding FT-eSET group but not significantly. In the IUI preceding FT-eSET group, the biochemical and clinical abortion rates were lower than in the control group (9.5% vs. 14.2% and 5.5% vs. 5.2%, respectively). However, no statistically significant difference was found between the two groups, either.ConclusionsThis is the first study showing that IUI may precede FT-eSET to improve PR in couples with unexplained subfertility. Also, performing IUI before FT-eSET may decrease biochemical and clinical abortion rates.
lncRNA LINC00152 knockdown suppressed hepatic cancer biological activity
Authors: Ma Yajun , Yang Xuli , Xu Yong , Zhou Rongping , Chen Gang , Fan Deseng , Luo Shikun , Shen Zhili , Yang Dong 
Published: September 2020

IntroductionHepatic cancer is one of the most lethal cancers and has a poor prognosis. The purpose of this study was to evaluate whether lncRNA LINC 00152 had effects on the development of hepatic cancer and the related mechanisms.Material and methodsMeasuring LINC 00152 in different tissues. In in vitro experiments, we knocked down LINC 00152 expression using si-LINC00152 in HepG2 cells and evaluated cell proliferation by MTT, apoptosis by flow cytometry, invasion by Transwell, and migration by wound healing. The relative protein was evaluated by western blot. In vivo experiments included measuring tumour size and weight, using TUNEL to evaluate cell apoptosis, and measurement of relative protein expression by IHC assay.ResultsIn our present study, first, we found that long non-coding RNA LINC00152 expression was significantly enhanced in hepatic cancer tissues and cell lines. Second, we revealed that LINC00152 knockdown had the effect of suppressing cell proliferation and metastasis and stimulating cell apoptosis in vitro. Third, LINC00152 down-regulation significantly suppressed tumour growth and increased cell apoptosis in an in vivo experiment. Mechanistic analyses showed that LINC00152 could regulate EGFR/PI3K/AKT/P21/MMP2/9 pathways in in vitro and in vivo experiments.ConclusionsOur results suggest that LINC00152 contributes to the oncogenic potential of hepatic cancer and that the EGFR/PI3K/AKT/P21/MMP2/9 signalling pathway might be a potential therapeutic target for hepatic cancer.
Assessing the role of serum prolactin levels and coding region somatic mutations of the prolactin gene in Saudi uterine leiomyoma patients
Authors: ElSokary Hanan Abdelhalim , Abdullah Layla Saleh , Ujaimi Amani , Sahly Nora Naif , Mansouri Nisma , Banaganapalli Babajan , Shaik Noor Ahmad , Elango Ramu , Bondagji Nabeel 
Published: September 2020

IntroductionUterine leiomyomas (UL) are highly prevalent benign smooth

muscle tumors, seen in approximately 70% of women. These hormone re-
sponsive tumors are also known to secrete prolactin (PRL), a hormone

of the anterior pituitary gland. Elevated levels of serum prolactin are a com-
mon clinical finding in different gynecological pathologies including UL.

However, the underlying causes for this elevation are not yet clear. Therefore,
the main objective of this study is to measure the serum PRL in UL patients
and also to investigate its molecular connection with coding region somatic
mutations of the PRL gene.Material and methodsThe serum PRL levels of UL patients were measured
through the ELISA method. The coding region PRL gene mutations in UL
and corresponding myometrium tissues were screened through the Sanger
sequencing method.ResultsUterine leiomyoma patients demonstrated significant elevation

of the PRL hormone level in serum samples (p ≤ 0.01). No somatic coding re-
gion mutations in the PRL gene were identified. However, four germline vari-
ants (c.570G>A, c.205-102T>A, c.312+177T>C and c.269C>T) were detected.ConclusionsThis study is the first one to confirm that serum PRL level ele-
vation among UL patients is not connected to somatic mutations in the PRL

gene. However, PRL genetic polymorphisms may indirectly contribute to the
disease etiology.
Reduction of lymphocyte count at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study
Authors: Fei Jun , Fu Lin , Li Ying , Xiang Hui-Xian , Xiang Ying , Li Meng-Die , Liu Fang-Fang , Xu De-Xiang , Zhao Hui 
Published: September 2020

IntroductionSeveral reports have noted that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induced lymphopenia in coronavirus disease 2019 (COVID-19) patients. However, the clinical significance of lymphopenia remains unclear. The objective of this study was to analyze the association between lymphopenia at an early stage and the prognosis of COVID-19 patients.Material and methodsAll 192 hospitalized patients with COVID-19 were enrolled. Demographic data and clinical characteristics were collected and patient’s prognosis was followed up.ResultsOn admission, 84 (43.8%) patients suffered from lymphopenia among COVID-19 patients. The count and percentage of lymphocytes on admission were lower among patients over 70 years old than those of younger patients. Multivariate logistic regression revealed that older age was a risk factor of lymphopenia. Of interest, chest CT score, a key marker of lung injury, was increased among COVID-19 patients with lymphopenia. By contrast, PaCO2, SpO2 and oxygenation index, several respiratory function markers, were decreased in COVID-19 patients with lymphopenia. Moreover, total bilirubin (TBIL) and direct bilirubin (DBIL), two markers of hepatic injury, creatinine and urea nitrogen, two indices of renal function, and creatine kinase, AST and LDH, three myocardial enzymes, were elevated in COVID-19 patients with lymphopenia. Among 84 COVID-19 patients with lymphopenia, 32.1% died. The fatality rate was obviously higher in COVID-19 patients with lymphopenia.ConclusionsOlder COVID-19 patients are more susceptible to lymphopenia. Multiple organ injuries were more serious in COVID-19 patients with lymphopenia. Lymphopenia at an early stage aggravates the severity and elevates the death risk of COVID-19 patients.
Analysis of major otosclerosis-associated variants in RELN and TGFB1 genes in Polish patients
Authors: Oziębło Dominika , Domagała Sara , Leja Marcin L. , Skarżyński Henryk , Ołdak Monika 
Published: September 2020

IntroductionOtosclerosis (OTSC) is one of the most common causes of progressive adult-onset hearing loss in the Caucasian population, with a female preponderance. The etiology of OTSC is complex and there are a number of genetic variants reported to be associated with OTSC susceptibility, but no data on the genetic background of OTSC in patients originating from the central-eastern part of Europe have been available. The purpose of our study was to investigate in Polish patients the frequency of genetic variants previously reported to be most strongly associated with OTSC.Material and methodsGenomic DNA was isolated from blood samples or buccal swabs. Variants in TGFB1 (rs1800472) and RELN (rs39335, rs39350, rs39374) were genotyped in surgically confirmed OTSC patients (n = 94) and a control group (n = 198) using custom TaqMan SNP genotyping assays and real-time PCR. Allele and genotype frequencies were compared between the groups in statistical analysis and the odds ratios with 95% confidence intervals were calculated to estimate the risk.ResultsFor all of the tested variants the distributions of alleles and geno­types were not statistically significantly different between OTCS patients and the control group. There were also no statistically significant differences in relation to gender of the tested subjects.ConclusionsDespite multiple confirmatory studies on TGFB1 and RELN association with OTSC development in some populations, no significant association between the studied variants and OTSC was found in Polish patients. Our results indicate the presence of inter-population differences in OTSC susceptibility factors and confirm the large genetic heterogeneity of this disorder.
The new method, the old problem – role of contrast-enhanced spectral mammography in the diagnosis of breast cancer among Polish women
Authors: Steinhof-Radwańska Katarzyna , Grażyńska Anna , Barczyk-Gutkowska Anna , Kajor Maciej , Powązka Piotr , Lorek Andrzej , Szlachta-Świątkowska Ewa , Morawska Irmina , Okas Karolina , Lelek Zuzanna , Bielińska Magdalena , Gisterek Iwona , Casańas Beata , Pilch-Kowalczyk Joanna 
Published: September 2020

IntroductionThe aim of the study was to evaluate spectral mammography (CESM) in diagnosing breast cancer, which is based on sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).Material and methodsThe study included a group of 547 women who underwent spectral mammography and
histopathological verification of the lesion, previously seen in mammography and/or ultrasound. In the group of
547 women, 593 focal lesions were diagnosed. All CESM examinations were carried-out with a digital mammography device dedicated to performing dual-energy CESM acquisitions. An intravenous injection of 1.5 ml/kg of body mass of non-ionic contrast agent was performed.ResultsThe analysis includes 593 breast lesions, in this group cancer was detected in 327 (55.14%) lesions, and in 256 (43.17%) cases benign lesions were confirmed by histopathological examination and at least 12 months of observation. The method shows differentiation of benign and malignant lesions in the breast: sensitivity of 97.86%, specificity of 59.4%, PPV – 74.76%, NPV – 95.76%.ConclusionsSpectral mammography could be an ideal method to detect breast cancer. Thanks to the high NPV (95.76%), it facilitates the exclusion of cancer in situations where pathological contrast enhancement is not observed. The unsatisfactory specificity of the study (59.4%) would not make it safe to avoid a core needle biopsy of lesions that undergo contrast enhancement.
Magnetic resonance imaging of the shoulder
Authors: Ashir Aria , Lombardi Alecio , Jerban Saeed , Ma Yajun , Du Jiang , Y. Chang Eric 
Published: September 2020

The aim of this article is to review the use of magnetic resonance imaging (MRI) for the evaluation of shoulder pain, which is a common clinical complaint of the musculoskeletal system. MRI is an essential auxiliary tool to evaluate these patients because of its high resolution and high sensitivity in depicting the soft tissues. This article will review the imaging technique, normal imaging anatomy, and most common imaging findings of disorders of tendons, labrum, and ligaments of the shoulder. It will also discuss common systemic diseases that manifest in the shoulder as well as disorders of the acromioclavicular joint and bursae. New advances and research in MRI have provided additional potential uses for evaluating shoulder derangements.
A curadoria de dados científicos na Ciência da Informação: levantamento do cenário nacional
Authors: Resende Liliane Chaves de , Bax Marcello Peixoto 
Published: September 2020

Para a ciência contemporânea, o compartilhamento de dados constitui elemento primordial para seu progresso e colaboração entre comunidades científicas. No contexto da ciência aberta e e-science, a ciência da informação investiga soluções para os desafios do tratamento e uso da informação. O desconhecimento atual da importância das atividades de curadoria digital dos dados científicos e do grau de adesão com esse novo cenário, causam dificuldades para o profissional da informação se adequar nesse contexto e contribuir com soluções para os desafios de curadoria digital. O objetivo da pesquisa é investigar a importância que as atividades de Curadoria digital de dados científicos têm para a área da Ciência da Informação no Brasil, frente à tendência internacional do gerenciamento do conhecimento científico. A pesquisa segue abordagem quantitativa, é de natureza aplicada e do tipo exploratória e descritiva. Utilizou-se de procedimentos de uma pesquisa com Survey, para obter informações da Curadoria Digital por meio da opinião dos pesquisadores brasileiros da área da Ciência da Informação. As informações analisadas revelam que o campo da Ciência da Informação brasileira está buscando se adaptar nesse cenário. Os dados permitem afirmar, que ainda não há uma conscientização suficientemente assimilada pelos pesquisadores da Ciência da Informação em relação à necessidade de envolvimento mais consciente e comprometido nas atividades de Curadoria Digital. Novas pesquisas são indicadas para aprofundar esta discussão.
If you build it, they will come: rapid colonization by dragonflies in a new effluent-dependent river reach
Authors: Bogan Michael T. , Eppehimer Drew , Hamdhani Hamdhani , Hollien Kelsey 
Published: September 2020

BackgroundAquatic ecosystems are greatly altered by urban development, including the complete loss of natural habitat due to water diversions or channel burial. However, novel freshwater habitats also are created in cities, such as effluent-dependent streams that rely on treated wastewater for flow. It is unclear how diverse these novel ecosystems are, or how quickly aquatic species are able to colonize them. In this study, we (1) quantify odonate (Insecta, Odonata) colonization of a novel effluent-dependent river reach, (2) examine how drying events affect odonates in these novel habitats, and (3) explore whether effluent-dependent streams can support diverse odonate assemblages.MethodsWe conducted monthly odonate surveys at three sites along the Santa Cruz River (Tucson, AZ, USA) between June 2019 and May 2020. One site was in a long-established effluent-dependent reach (flowing since the 1970s) that served as a reference site and two sites were in a newly-established reach that began flowing on June 24, 2019 (it was previously dry). We compared odonate species richness, assemblage composition, and colonization patterns across these reaches, and examined how these factors responded to flow cessation events in the new reach.ResultsSeven odonate species were observed at the study sites in the new reach within hours of flow initiation, and species rapidly continued to arrive thereafter. Within 3 months, species richness and assemblage composition of adult odonates were indistinguishable in the new and reference reaches. However, drying events resulted in short-term and chronic reductions in species richness at one of the sites. Across all three sites, we found over 50 odonate species, which represent nearly 40% of species known from the state of Arizona.DiscussionOdonates were surprisingly diverse in the effluent-dependent Santa Cruz River and rapidly colonized a newly established reach. Richness levels remained high at study sites that did not experience drying events. These results suggest that consistent discharge of high-quality effluent into dry streambeds can be an important tool for promoting urban biodiversity. However, it remains to be seen how quickly and effectively less vagile taxa (e.g., mayflies, caddisflies) can colonize novel reaches. Effluent-dependent urban streams will always be highly managed systems, but collaboration between ecologists and urban planners could help to maximize aquatic biodiversity while still achieving goals of public safety and urban development.
Biological function of Klebsiella variicola and its effect on the rhizosphere soil of maize seedlings
Authors: Yang Lijuan , Yang Kejun 
Published: September 2020

Background
Deterioration of the ecological environment in recent years has led to increasing soil salinization, which severely affects the cultivation of agricultural crops. While research has focused on improving soil environment through the application of pollution-free microbial fertilizers, there are relatively few plant growth-promoting bacteria suitable for saline-alkali environments. Although Klebsiella variicola can adapt to saline-alkali environments to successfully colonize rhizosphere microenvironments, only a few studies have investigated its role in promoting crop growth. Its effect on the crop rhizosphere soil microenvironment is especially unclear.

Methods
In this study, the biological function of K. variicola and its colonization in maize seedling rhizosphere soil were studied in detail through selective media and ultraviolet spectrophotometry. The effects of K. variicola on the rhizosphere soil microenvironment and the growth of maize seedlings in saline-alkali and neutral soils were systematically analysed using the colorimetric method, the potassium dichromate volumetric method, and the diffusion absorption method.

Results
Our results showed that K. variicola played a role in indole acetic acid, acetoin, ammonia, phosphorus, and potassium production, as well as in nitrogen fixation. A high level of colonization was observed in the rhizosphere soil of maize seedlings. Following the application of K. variicola in neutral and saline-alkali soils, the nutrient composition of rhizosphere soil of maize seedlings increased in varying degrees, more notably in saline-alkali soil. The content of organic matter, alkali-hydrolysable nitrogen, available phosphorus, available potassium, alkaline phosphatase, sucrase, urease, and catalase increased by 64.22%, 117.39%, 175.64%, 28.63%, 146.08%, 76.77%, 86.60%, and 45.29%, respectively, insaline-alkalisoil.

Conclusion
K.variicola, therefore, performed a variety of biological functions to promote the growth of maize seedlings and effectively improve the level of soil nutrients and enzymes in the rhizosphere of maize seedlings, undersaline-alkali stress conditions. It played an important role in enhancing the rhizosphere microenvironment of maize seedlings under saline-alkali stress.