bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultivation of microalgae for biofuel production: coupling with sugarcane-processing factories
Authors: Zewdie Deribew Tefera , Ali Abubeker Yimam 
Published: August 2020

Abstract
Background
Despite their potential as biofuel resources, large-scale production of biofuels from microalgae is still uncertain primarily due to a lack of feasibility of the process and that it proves to be capital and energy intensive. Therefore, an integration of microalgal cultivation with other processes for achieving an inexpensive nutrient and energy use is an important issue. In the present study, the potential of the flue gas and the wastewater of a sugar factory to support microalgae growth for biofuel and bio-fertilizer production is evaluated.

Methods
The study was carried out by following a case study approach; an Ethiopian sugarcane-processing factory, Metahara sugar and ethanol production factory, was selected for this purpose. Conceptual microalgal biofuel production was integrated with the real sugarcane-processing factory, and the process was evaluated with regard to the product outputs and energy requirements.

Results
The integrated process model shows that three products, biodiesel, upgraded biogas, and bio-fertilizer with production capacities of 188 tons/year, 1,974,882 m3/year and 42 tons/year, respectively, were produced. For the production of these products, the electricity and thermal energy demand of the integrated process amounted to 1822.13 and 3244.99 MWh/year, respectively. A sensitivity analysis shows that the oil content of the algae, the nitrogen content of the waste, the oil extraction efficiency, and the transesterification efficiency are the main factors which affect the biodiesel production capacity of the integrated process.

Conclusions
This case study approach investigated the potential of a future possible bio-refinery and environmental pollution reduction concept by integrating microalgae biomass production with sugarcane-processing factory wastes and by-products. It was found that the factory wastes and by-products have a significant potential for a viable biofuel production from microalgae.
Radiomics for glioblastoma survival analysis in pre-operative MRI: exploring feature robustness, class boundaries, and machine learning techniques
Authors: Suter Yannick , Knecht Urspeter , Alão Mariana , Valenzuela Waldo , Hewer Ekkehard , Schucht Philippe , Wiest Roland , Reyes Mauricio 
Published: August 2020

Abstract
Background
This study aims to identify robust radiomic features for Magnetic Resonance Imaging (MRI), assess feature selection and machine learning methods for overall survival classification of Glioblastoma multiforme patients, and to robustify models trained on single-center data when applied to multi-center data.

Methods
Tumor regions were automatically segmented on MRI data, and 8327 radiomic features extracted from these regions. Single-center data was perturbed to assess radiomic feature robustness, with over 16 million tests of typical perturbations. Robust features were selected based on the Intraclass Correlation Coefficient to measure agreement across perturbations. Feature selectors and machine learning methods were compared to classify overall survival. Models trained on single-center data (63 patients) were tested on multi-center data (76 patients). Priors using feature robustness and clinical knowledge were evaluated.

Results
We observed a very large performance drop when applying models trained on single-center on unseen multi-center data, e.g. a decrease of the area under the receiver operating curve (AUC) of 0.56 for the overall survival classification boundary at 1 year. By using robust features alongside priors for two overall survival classes, the AUC drop could be reduced by 21.2%. In contrast, sensitivity was 12.19% lower when applying a prior.

Conclusions
Our experiments show that it is possible to attain improved levels of robustness and accuracy when models need to be applied to unseen multi-center data. The performance on multi-center data of models trained on single-center data can be increased by using robust features and introducing prior knowledge. For successful model robustification, tailoring perturbations for robustness testing to the target dataset is key.
Paleosols in an outcrop of red beds from the Upper Cretaceous Yaojia Formation, southern Songliao Basin, Jilin Province, NE China
Authors: Zhang Li , Bao Zhi-Dong , Zhang Chang-Min , Dou Lu-Xing , Fu Ping , Zhao Jia-Hong , Wang Wu-Xue , Ji Yu 
Published: August 2020

AbstractPaleosols in an outcrop of fluvial–lacustrine red beds have been recognized in the Upper Cretaceous Yaojia Formation in southern Songliao Basin, Songyuan City, Jilin Province, NE China. They are recognized in the field by pedogenic features, including root traces and burrows, soil horizons and soil structures. Root traces are remnants of small herbaceous plants, elongating and branching downwards in the red paleosols. They are filled by calcite, analcime, and clay minerals in spaces created by the decay of the plant roots. Burrows are found near the root traces with backfilled cells made by soil-dwelling insects. Soil horizons include calcic horizons (Bk horizon) with continuous calcareous layers, argillic horizons (Bt horizon) with clay films and dark brown to black iron-manganese cutans, vertic horizons (Bw horizon) with slickensided claystone, and deformed soil structure and gleyed horizons (Bg horizon) with mottles and reticulate mottles. Soil structures of the paleosols include pseudo-anticlinal structures, subangular blocky structures, and angular blocky structures. The micro-pedogenesis characteristics are also observed, including micrite pedogenic minerals and clay skins. Based on the pedogenic features above, paleosols types including Aridisol, Alfisol, and Vertisol are interpreted in the red beds of the Yaojia Formation. Forming in the Late Cretaceous, the paleosols can provide more details about the seasonal climate conditions and terrestrial sedimentary system in lacustrine basin.
Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment
Authors: Allott Kelly , Gao Caroline , Hetrick Sarah E. , Filia Kate M. , Menssink Jana M. , Fisher Caroline , Hickie Ian B. , Herrman Helen E. , Rickwood Debra J. , Parker Alexandra G. , Mcgorry Patrick D. , Cotton Sue M. 
Published: August 2020

Background
Subjective cognitive difficulties are common in mental illness and have a negative impact on role functioning. Little is understood about subjective cognition and the longitudinal relationship with depression and anxiety symptoms in young people.

Aims
To examine the relationship between changes in levels of depression and anxiety and changes in subjective cognitive functioning over 3 months in help-seeking youth.

Method
This was a cohort study of 656 youth aged 12–25 years attending Australian headspace primary mental health services. Subjective changes in cognitive functioning (rated as better, same, worse) reported after 3 months of treatment was assessed using the Neuropsychological Symptom Self-Report. Multivariate multinomial logistic regression analysis was conducted to evaluate the impact of baseline levels of and changes in depression (nine-item Patient Health Questionnaire; PHQ9) and anxiety symptoms (seven-item Generalised Anxiety Disorder scale; GAD7) on changes in subjective cognitive function at follow-up while controlling for covariates.

Results
With a one-point reduction in PHQ9 at follow-up, there was an estimated 11–18% increase in ratings of better subjective cognitive functioning at follow-up, relative to stable cognitive functioning. A one-point increase in PHQ9 from baseline to follow-up was associated with 7–14% increase in ratings of worse subjective cognitive functioning over 3 months, relative to stable cognitive functioning. A similar attenuated pattern of findings was observed for the GAD7.

Conclusions
A clear association exists between subjective cognitive functioning outcomes and changes in self-reported severity of affective symptoms in young people over the first 3 months of treatment. Understanding the timing and mechanisms of these associations is needed to tailor treatment.
Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Ocular Melanoma Metastases Confined to the Liver: A Prospective Phase II Study
Authors: Meijer T. Susanna , Burgmans Mark C. , de Leede Eleonora M. , de Geus-Oei Lioe-Fee , Boekestijn Bas , Handgraaf Henricus J. M. , Hilling Denise E. , Lutjeboer Jacob , Vuijk Jaap , Martini Christian H. , van Erkel Arian R. , van der Meer Rutger W. , Tijl Fred G. J. , Speetjens Frank M. , Kapiteijn Ellen , Vahrmeijer Alexander L. 
Published: August 2020

Abstract
Background
Ocular melanoma is the most common primary intraocular malignancy and has a very poor prognosis once liver metastases occur. The
aim of this study was to prospectively assess the efficacy and safety of percutaneous hepatic perfusion with melphalan (M-PHP) using the new second-generation
(GEN 2) hemofiltration system in patients with ocular melanoma metastases confined to the liver.

Methods
Prospective, single-center, single-arm, phase II study including patients with unresectable ocular melanoma metastases confined to the liver. Treatment consisted of two M-PHP procedures at 6–8 weeks interval. Procedures were performed using the CHEMOSAT (GEN 2) system with 3 mg/kg
melphalan. Primary endpoints were overall response rate (ORR) and best overall response (BOR). Secondary endpoints included overall survival (OS), progression-free survival (PFS), hepatic PFS (hPFS), and safety.

Results
Sixty-four M-PHP procedures were performed in 35 patients between February 2014 and June 2017. The ORR was 72%. BOR was as follows: complete response in 3%, partial response in 69%, stable disease in 13%, and progressive disease in 16%. There was no treatment-related mortality. Fourteen serious adverse events occurred. At a median follow-up of 19.1 months (range 5.6–69.5), median OS was 19.1 months and was significantly longer in responders than in nonresponders (27.5 vs. 11.9 months, p < 0.001). The 1- and 2-year OS was 77% and 43%, respectively. PFS and hPFS were 7.6 and 11.2 months, respectively.

Conclusions
M-PHP using the GEN 2 filter can achieve a high ORR and prolonged survival in patients with liver-only ocular melanoma metastases.
Customer Preference and Station Network in the London Bike-Share System
Authors: He Pu , Zheng Fanyin , Belavina Elena , Girotra Karan 
Published: August 2020

We study customer preference for the bike-share system in the city of London. We estimate a structural demand model on the station network to learn the preference parameters and use the estimated model to provide insights on the design and expansion of the bike-share system. We highlight the importance of network effects in understanding customer demand and evaluating expansion strategies of transportation networks. In the particular example of the London bike-share system, we find that allocating resources to some areas of the station network can be 10 times more beneficial than others in terms of system usage and that the currently implemented station density rule is far from optimal. We develop a new method to deal with the endogeneity problem of the choice set in estimating demand for network products. Our method can be applied to other settings in which the available set of products or services depends on demand. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.
Pendidikan Seks Dalam Islam Berbasis Komunikasi Orangtua-Anak: Langkah Pencegahan LGBT Pada Anak
Authors: Wati Dewi Eko 
Published: August 2020

AbstrakPembahasan artikel ini dibatasi pada LGBT ditinjau dari sisi psikologi dan agama. Tujuan penulisan artikel ini untuk memberikan wawasan khususnya kepada orangtua mengenai pentingnya hubungan yang hangat dan harmonis antara orangtua dan anak sebagai upaya pencegahan LGBT melalui penanaman pendidikan seks pada anak dalam tinjauan agama Islam. Metode yang digunakan ialah kajian literatur. Dari tinjauan agama, Majelis Ulama Indonesia (MUI) mengharamkan perilaku LGBT karena merupakan kejahatan yang dapat menimbulkan penyakit yang berbahaya bagi kesehatan seperti sifilis, hepatitis B, dan HIV/AIDS. Dari tinjauan psikologi, LGBT bisa mengganggu kesejahteraan psikologis seseorang. Oleh karena itu, upaya pencegahan perlu dilakukan sejak dini dimulai dari keluarga yaitu orangtua melalui pendidikan seks yang tepat. Penanaman pendidikan seks terhadap anak harus dilakukan dalam hubungan orangtua dan anak yang hangat dan harmonis agar anak mampu menerimanya dengan baik. Komunikasi orangtua-anak yang didasarkan pada kepercayaan dan keterbukaan menjadi kunci dalam melakukan pendidikan seks yang nyaman bagi anak.Kata kunci: pendidikan seks, komunikasi, orangtua-anak, LGBT
Indoor optical wireless communication system with filters-enhanced generalized spatial modulation and carrierless amplitude and phase (CAP) modulation
Authors: Wang Ke 
Published: August 2020

The spatial modulation principle has been widely studied in indoor optical wireless communication (OWC) systems to provide high-speed connections to users by encoding part of data in the spatial domain. To further increase the speed and to eliminate the requirements of accurate channel state information (CSI) and low channel correlation, in this Letter we propose and demonstrate an indoor OWC system with a filters-enhanced generalized spatial modulation (FE-GSM) scheme and 16-carrierless amplitude and phase (16-CAP) modulation. The 16-CAP increases the data rate in symbol domain, and the FE-GSM scheme allows activating multiple transmitters simultaneously to increase data rate in the spatial domain. Experimental results show that using a 2.5 GBaud/s indoor OWC system with three transmitters, 15 Gb/s data rate is achieved even under identical channels without pre-known CSI. The demonstrated scheme provides a promising solution to increase data rate in indoor OWC systems.
Photonic scanning receiver for wide-range microwave frequency measurement by photonic frequency octupling and in-phase and quadrature mixing
Authors: Shi Jingzhan , Zhang Fangzheng , Zhou Yuewen , Pan Shilong , Wang Yiping , Ben De 
Published: August 2020

A photonic scanning receiver with optical frequency scanning and electrical intermediate frequency envelope detection is proposed to implement wide-range microwave frequency measurement. This system applies photonic in-phase and quadrature frequency mixing to distinguish and measure the signals in two frequency bands that mirror each other. Combined with the photonic frequency octupling technique, the proposed system has a frequency measurement range that is 16 times that of the sweeping range of the electrical signal source. Besides, optical frequency sweeping with up and down chirps is used to relax the requirement for precise synchronization between the sweeping source and the analog-to-digital converter. In the experiment, using an electrical sweeping local oscillator having a bandwidth of 1.75 GHz, the system achieves a frequency measurement range as large as 28 GHz. The measurement errors are kept within 24 MHz with an average error of 9.31 MHz.
Antitumor Necrosis Factor Agents to Treat Endoscopic Postoperative Recurrence of Crohn's Disease: A Nationwide Study With Propensity-Matched Score Analysis
Authors: Cañete Fiorella , Mañosa Míriam , Pérez-Martínez Isabel , Barreiro-de Acosta Manuel , González-Sueyro Ramiro C. , Nos Pilar , Iglesias-Flores Eva , Gutiérrez Ana , Bujanda Luis , Gordillo Jordi , Ríos León Raquel , Casanova María José , Villoria Albert , Rodríguez-Lago Iago , López Serrano Pilar , García-Herola Antonio , Ramírez-de la Piscina Patricia , Navarro-Llavat Mercè , Taxonera Carlos , Barrio Jesús , Ramos Laura , Navarro Pablo , Benítez-Leiva Olga , Calafat Margalida , Domènech Eugeni ,   on behalf of the INFLIRECU study
Published: August 2020

INTRODUCTION:
Patients with Crohn's disease experiencing endoscopic postoperative recurrence (POR) may benefit from antitumor necrosis factor (TNF) agents but scarce data on this are available. Our aim was to assess the efficacy of anti-TNF in improving mucosal lesions in patients with endoscopic POR.

METHODS:
Multicenter, retrospective, study of patients with Crohn's disease who underwent therapy with anti-TNF agents for endoscopic POR (Rutgeerts score > i1). Treatment outcomes were assessed by the findings in the last ileocolonoscopy performed after anti-TNF therapy was initiated. Endoscopic improvement and remission were defined as any reduction in the baseline Rutgeerts score and by a Rutgeerts score < i2, respectively.

RESULTS:
A total of 179 patients were included, 83 were treated with infliximab and 96 with adalimumab. Median time on anti-TNF therapy at the last endoscopic assessment was 31 months (interquartile range, 13–54). Endoscopic improvement was observed in 61%, including 42% who achieved endoscopic remission. Concomitant use of thiopurines and treatment with infliximab were associated with endoscopic improvement (odds ratio [OR] 2.15, 95% confidence interval [CI] 1.04–4.46; P = 0.03, and OR 2.34, 95% CI 1.18–4.62; P < 0.01, respectively) and endoscopic remission (OR 3.16, 95% CI 1.65–6.05; P < 0.01, and OR 2.01, 95% CI 1.05–3.88; P = 0.04, respectively) in the multivariable logistic regression analysis. These results were confirmed in a propensity-matched score analysis.

DISCUSSION:
In patients with endoscopic POR, anti-TNF agents improve mucosal lesions in almost two-thirds of the patients. In this setting, concomitant use of thiopurines and use of infliximab seem to be more effective in improving mucosal lesions.
Polymorphic variants in the PVT1 locus affect multiple sclerosis severity
Authors: Kiselev I. S. , Kozin M. S. , Baulina N. M. , Pavlova G. V. , Boyko A. N. , Kulakova O. G. , Favorova O. O. 
Published: August 2020

Multiple sclerosis (MS) is a chronic autoimmune disease, in the pathogenesis of which the concurrence of demyelination of central nervous system (CNS) axons and neurodegeneration plays a role and which is accompanied by progressive neurological dysfunction. Long-term monitoring of patients with MS is needed to rate its severity according to existing scales; it is therefore very relevant to search for genomic markers that can predict the rate of disease progression at early stages. The impact of polymorphic variants in the PVT1 locus on MS severity has not been previously studied.Objective: to analyze the association of the polymorphic variants rs4645948 in the MYC gene and rs2114358 and rs4410871) in the PVT1 genes with MS severity according to the Multiple Sclerosis Severity Scale (MSSS) separately and as part of biallelic combinations, as well as the possible linkage disequilibrium of the studied single nucleotide polymorphisms for establishing the independence of the observed associations.Patients and methods. The investigation enrolled 468 Russian MS patients who did not take immunomodulating drugs before blood testing. The patients were divided into two groups: 1) relatively mild MS (MSSS ≤3.5) and 2) relatively severe MS (MSSS >3.5). The polymorphic variants in the PVT1 locus were genotyped by a real-time polymerase chain reaction assay.Results and discussion. In the MS study group, the carriage of the allele of PVT1 (rs2114358)*G turned out to be associated with the severe course of the disease (pf=0.042; odds ratio (OR)=1.41). The significance of the association increases in the simultaneous carriage of this allele with another variant of the same gene – PVT1 (rs4410871)*T (pf=0.024; OR=1.58). There was no linkage disequilibrium between the components of the biallelic combination.Conclusion. The polymorphic variants in the PVT1 locus are associated with the severity of MS.
PENGENDALIAN KUALITAS PRODUK SELADA ROMAINE PADA SISTEM TANAM HIDROPONIK (Studi Kasus di UMKM Kebun Sayur, Kota Surabaya, Jawa Timur)
Authors: Novianti Nila , Subagyo Heru Santoso Hadi , Aprilia Anisa 
Published: August 2020

Kualitas produk merupakan salah satu faktor yang diperhatikan oleh konsumen dalam membeli dan menggunakan sebuah produk. Adanya peningkatan pendidikan, kemampuan daya beli serta kepedulian konsumen terhadap nilai gizi telah menggugah kesadaran konsumen akan pentingnya suatu kualitas produk. Namun pada kenyataannya produk sayuran hidroponik khususnya Selada Romaine yang diproduksi oleh UMKM Kebun Sayur Surabaya masih memiliki kualitas yang kurang baik. Permasalahan yang kerap muncul pada usaha tersebut yaitu adanya kecacatan produk. Sehingga penelitian ini dilakukan dengan tujuan menganalisis nilai kecacatan, faktor-faktor penyebab kecacatan dan harapan konsumen terhadap kualitas produk Selada Romaine. Penelitian dilakukan di UMKM Kebun Sayur Surabaya dengan menggunakan metode Statistical Quality Control (SQC) dan House of Quality (HoQ). Pengendalian kualitas menggunakan (SQC) dilakukan dengan lima alat statistik yaitu diagram alir, lembar pemeriksaan, diagram pareto, peta kendali, dan diagram sebab akibat. Hasil penelitian menunjukkan bahwa: (1) Nilai kecacatan produk Selada Romaine hidroponik berada di luar batas kendali UCL (Upper Control Limit) dan LCL (Lower Control Limit), sehingga dikatakan tidak terkendali. Terdapat 3 titik berada di dalam batas kendali dan 10 titik berada di luar batas kendali (2) Faktor-faktor yang menyebabkan kecacatan produk yaitu faktor mesin, faktor manusia faktor lingkungan dan faktor metode (3) Harapan konsumen terhadap kualitas produk yaitu harga produk Rp 4.000 per ons; bentuk produk yaitu utuh atau tidak terdapat daun bercak coklat, berlubang, kuning dan akar terlepas dari tanaman; kesegaran produk yaitu sangat segar atau fresh hasil panen; kebersihan produk yaitu sangat higienis melalui proses pencucian; warna produk yaitu hijau segar atau tidak terlalu tua dan muda; serta kemasan produk yaitu plastik terbuka seperti bucket bunga.