bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined electron-ion-plasma boriding of high-chrome austenitic steel
Authors: Ivanov Yu F , Petrikova E A , Teresov A D , Tolkachev O S , Romanov D A 
Published: December 2019

Abstract
A combined modification of the surface of high-chromium stainless steel 12Cr18Ni10Ti was carried out, including electro-explosive alloying with titanium and boron and subsequent irradiation with an intense pulsed electron beam. The formation of a multiphase submicro-nanocrystalline surface layer with a thickness of up to 70 μm was revealed. It was shown that the concentration of boron in the surface layer varies nonmonotonically, reaching a maximum value (≈19 at.%) at a distance of (10-15) μm from the alloying surface. It was established that the hardness and wear resistance of the modified steel layer exceeds the hardness of the initial state by 7 times, wear resistance - more than 9 times.
Self-propagating high-temperature synthesis of oxide bronzes with regulated composition and properties
Authors: Sologubova I A , Kotvanova M K , Pavlova S S 
Published: December 2019

Abstract
The work is devoted to the preparation of oxide tungsten bronzes of various compositions and various structures by the SHS method. The work is aimed at the realization of the ability to control the composition, structure and properties of SHS products. Brightness pyrometry technique was used for the experimental evaluation of the temperature in the combustion wave. The values of the electrical conductivity of the obtained samples of oxide tungsten bronzes with constant current: for K0.25WO3 — 0,029 S/cm; K0.50WO3 — 0,046 S/cm. Carbon paste electrode was produced and tested based on an oxide bronze K0.50WO3.
The modification of hypereutectic high-alloy silumins — prospects for the development of technology for producing materials with a low linear expansion coefficient
Authors: Bochvar S G , Predko P Yu , Konkevich V Yu , Kostin I V 
Published: December 2019

Abstract
This article discusses the possibilities of using hypereutectic silumins and the problems that impede their wider distribution. The known methods of manufacturing products from hypereutectic silumins of high quality are shown. A method for producing casting blocks from hypereutectic silumins by direct chill casting is considered. The possibility of milling primary silicon crystals by introducing modifiers and master alloys of Al-Si-P, Al-Cu-P systems, inorganic carbon and phosphorus compounds is shown. The tendency of copper-doped silumins to hot shortness is shown. The technology of impact on the melt of ultrasonic cavitation is considered together with the introduction of additional active modifiers made of master alloy rods to obtain casting blocks from hypereutectic high-alloy silumins using the method of direct chill casting with a primary silicon crystal size of no more than 10 µm. Technological principles for reducing the grain size of α-solid solution, uniformly distributed over the ingot cross-section, are proposed.
Electron irradiation of palladium-copper alloy
Authors: Simakov S V , Ashmarin A A , Vinogradova N A , Nikitushkina O N 
Published: December 2019

Abstract
The process of high-energy electron irradiation of the Cu – 40 Pd alloy in air under 350 °C is considered. After irradiation, a layer of copper oxide CuO was formed on the alloy surface, which under normal thermal conditions forms at the temperature of 400 – 500 °C. Reflections of the ordered β-phase disappeared in the surface layer. The elemental composition of the alloy changed along the distance from irradiated surface of the metal. Phases with low degree of long-range order and an increased palladium content formed. The presence of these phases is caused by selective oxidation of copper.
Effect of an additive TEA on thiosulfate leaching of low sulfur gold concentrate
Authors: Zhao Hefei , Yang Hongying , Shi Wenge , Lu Liangshan , Ma Pengcheng , Li Hong , Chen Xi 
Published: December 2019

Abstract
The environmentally friendly and non-cyanide thiosulfate gold leaching technology was used to extract gold from a low-sulfur gold concentrate. The effect of TEA on leaching of pure gold under the condition of adding quartz indicated that TEA could significant increase the dissolution rates of gold and the mixed solution potentials and decrease the consumption of thiosulfate. Quartz has little effect on the gold leaching process. Moreover, the effect of additive Triethanolamine (TEA) on the gold extraction was further studied. The chemical analysis and process mineralogy analysis of the concentrate indicated that the concentrate contained 59 g/t Au, 64.49% SiO2, 19.55% Al and 5.76% Fe. The concentrate was composed of quartz, muscovite and chlorite as major minerals. Quartz was the main gold-bearing mineral in concentrate. The gold particles of less than 20 μm in the concentrate reached 50.56%. Traditional thiosulfate leaching technology was used to extract gold from the concentrate, and the gold leaching rate was only 44.49% after 48 hours. When 0.024 M (MTEA:Mcopper=2:1) TEA was added in the thiosulfate leaching gold system, the thiosulfate consumption significantly reduced by about 32% and the leaching rate of gold increased to 73.40%.
Structure and properties of the electromagnetic starter’s contacts with the electro-explosive CuO-Ag coating
Authors: Romanov D A , Moskovskii S V , Gromov V E , Ivanov Yu F , Filjakov A D 
Published: December 2019

Abstract
Phases and elemental composition of CJ20 electromagnetic starter’s contacts subjected to electro-explosive spraying of the CuO-Ag coating were studied by using transmission and scanning electron microscopy methods. Electro-explosive spraying CuO-Ag coating were carried out in mode providing contact’s premelting condition. Such mode managed to minimize energy cost. Produced coating has a homogeneous structure containing silver matrix and CuO inclusions located in the matrix. After electro-explosive spraying the structure of coating elements’ surface and their scale vary in a very wide range from thousands µm to tens of hundreds µm. The high-speed cellular crystallization’s structure is formed in the electro-explosive CuO-Ag coating regardless of distance to modifying surface. The cell’s size is ranged from 150 nm to 300 nm. The cells are separated by the second phase’s layers which thickness varies from 10 nm to 70 nm. The cell is volume formed by copper atoms; silver atoms are located in interlayers along the cell boundaries. Sprayed coatings were tested for wear resistance, friction coefficient, nanohardness and Young’s modulus. The formed coating shows an increase in 2.0 times nanohardness, in 3.3 times wear-resistance and in 1.4 times friction coefficient and decrease to 5.3 times Young’s modulus in comparison with the original copper electrical contact.
Research and control of network carbide in GCr15 bearing steel
Authors: Huo Xiangdong , Ning Yuliang , Li Liejun , Lv Zhiwei , Chen Songjun 
Published: December 2019

Abstract
Due to the small amount of transformation during the phase transformation process, it is difficult to determine the phase transition temperature of the proeutectoid cementite in the bearing steel by the expansion method. In this paper, the Gleeble3800 thermal simulator was used to study the phase transformation behavior of GCr15 bearing steel at different cooling rates. Firstly, the phase transformation temperature range of pearlite is about 550 °C ∼ 700 °C measured by expansion method. Based on this, the transformation temperature range of proeutectoid cementite is about 700 °C ∼ 900 °C studied by metallographic method; The precipitation curve of proeutectoid cementite was supplemented, and the complete continuous cooling phase transition curve (CCT curve) of bearing steel was drawn. On this basis, the scheme of inhibiting the formation of proeutectoid cementite by two-stage cooling process was proposed and discussed, and the finishing cooling temperature was studied, which provides a basis for controlling network carbide in field production.
LeukmiR: a database for miRNAs and their targets in acute lymphoblastic leukemia
Authors: Rawoof Abdul , Swaminathan Guruprasadh , Tiwari Shrish , Nair Rekha A , Dinesh Kumar Lekha 
Published: December 2019

Abstract
Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies in children. Recent studies suggest the involvement of multiple microRNAs in the tumorigenesis of various leukemias. However, until now, no comprehensive database exists for miRNAs and their cognate target genes involved specifically in ALL. Therefore, we developed ‘LeukmiR’ a dynamic database comprising in silico predicted microRNAs, and experimentally validated miRNAs along with the target genes they regulate in mouse and human. LeukmiR is a user-friendly platform with search strings for ALL-associated microRNAs, their sequences, description of target genes, their location on the chromosomes and the corresponding deregulated signaling pathways. For the user query, different search modules exist where either quick search can be carried out using any fuzzy term or by providing exact terms in specific modules. All entries for both human and mouse genomes can be retrieved through multiple options such as miRNA ID, their accession number, sequence, target genes, Ensemble-ID or Entrez-ID. User can also access miRNA: mRNA interaction networks in different signaling pathways, the genomic location of the targeted regions such as 3′UTR, 5′UTR and exons with their gene ontology and disease ontology information in both human and mouse systems. Herein, we also report 51 novel microRNAs which are not described earlier for ALL. Thus, LeukmiR database will be a valuable source of information for researchers to understand and investigate miRNAs and their targets with diagnostic and therapeutic potential in ALL.
Database URL: http://tdb.ccmb.res.in/LeukmiR/
Can evidence-based decision support tools transform antibiotic management? A systematic review and meta-analyses
Authors: Laka Mah , Milazzo Adriana , Merlin Tracy 
Published: December 2019

Abstract

Objectives
To assess the effectiveness of clinical decision support systems (CDSSs) at reducing unnecessary and suboptimal antibiotic prescribing within different healthcare settings.

Methods
A systematic review of published studies was undertaken with seven databases from database inception to November 2018. A protocol was developed using the PRISMA-P checklist and study selection criteria were determined prior to performing the search. Critical appraisal of studies was undertaken using relevant tools. Meta-analyses were performed using a random-effects model to determine whether CDSS use affected optimal antibiotic management.

Results
Fifty-seven studies were identified that reported on CDSS effectiveness. Most were non-randomized studies with low methodological quality. However, randomized controlled trials of moderate methodological quality were available and assessed separately. The meta-analyses indicated that appropriate antibiotic therapy was twice as likely to occur following the implementation of CDSSs (OR 2.28, 95% CI 1.82–2.86, k = 20). The use of CDSSs was also associated with a relative decrease (18%) in mortality (OR 0.82, 95% CI 0.73–0.91, k = 18). CDSS implementation also decreased the overall volume of antibiotic use, length of hospital stay, duration and cost of therapy. The magnitude of the effect did vary by study design, but the direction of the effect was consistent in favouring CDSSs.

Conclusions
Decision support tools can be effective to improve antibiotic prescribing, although there is limited evidence available on use in primary care. Our findings suggest that a focus on system requirements and implementation processes would improve CDSS uptake and provide more definitive benefits for antibiotic stewardship.
Deep packet inspection for intelligent intrusion detection in software-defined industrial networks: A proof of concept
Authors: Sainz Markel , Garitano Iñaki , Iturbe Mikel , Zurutuza Urko 
Published: December 2019

Abstract
Specifically tailored industrial control systems (ICSs) attacks are becoming increasingly sophisticated, accentuating the need of ICS cyber security. The nature of these systems makes traditional IT security measures not suitable, requiring expressly developed security countermeasures. Within the past decades, research has been focused in network-based intrusion detection systems. With the appearance of software-defined networks (SDNs), new opportunities and challenges have shown up in the research community. This paper describes the potential benefits of using SDNs in industrial networks with security purposes and presents the set up and results of a pilot experiment carried out in a scaled physical implementation. The experimental set up consists in the detection of ICMP flood and packet payload alteration based on signature comparison. Results point to the potential viability of the technology for intrusion detection and the need of researching in architectural scalability.
Cosmic ray interactions in the solar atmosphere
Authors: Hudson Hugh S , MacKinnon Alec , Szydlarski Mikolaj , Carlsson Mats 
Published: December 2019

ABSTRACT
High-energy particles enter the solar atmosphere from Galactic or solar coronal sources, and produce ‘albedo’ emission from the quiet Sun that is now observable across a wide range of photon energies. The interaction of high-energy particles in a stellar atmosphere depends essentially upon the joint variation of the magnetic field and plasma density, which heretofore has been characterized parametrically as P ∝ Bα with P the gas pressure and B the magnitude of the magnetic field. We re-examine that parametrization by using a self-consistent 3D MHD model (Bifrost) and show that this relationship tends to P ∝ B3.5 ± 0.1 based on the visible portions of the sample of open-field flux tubes in such a model, but with large variations from point to point. This scatter corresponds to the strong meandering of the open-field flux tubes in the lower atmosphere, which will have a strong effect on the prediction of the emission anisotropy (limb brightening). The simulations show that much of the open flux in coronal holes originates in weak-field regions within the granular pattern of the convective motions seen in the simulations.
X-ray reverberation lags from the 1.5 Seyfert galaxy NGC 5273
Authors: Vincentelli F M , Mastroserio G , McHardy I , Ingram A , Pahari M 
Published: December 2019

ABSTRACT
We present the results of X-ray spectral-timing analysis of a 90 ks XMM–Newton observation of the nearby, broad-line, early-type AGN NGC5273. The X-ray spectrum revealed the clear presence of a reflection component at high energies, with a clear signature of a narrow iron line at 6.4 keV, consistent with distant reflection. Applying a relativistic reflection model, we found only marginal evidence for a broader relativistic line component. However, cross-spectral analysis revealed that, between 4 and 6 × 10−4 Hz, the 5–8 keV band lagged the 2–3 keV band, implying reflection of the iron line from material close to the black hole. From the analysis of the lag-energy spectrum, we found a broad, but skewed line with a peak of ≈1000 s at 7.5 keV relative to the continuum, which we interpret as the iron line in the reverberation spectrum from an illuminated accretion disc. From the asymmetry in the shape of lag-energy spectrum, we also found that the source is consistent with having an inclination ≥45°.
Characterizing the companion AGBs using surface chemical composition of barium stars
Authors: Shejeelammal J , Goswami Aruna , Goswami Partha Pratim , Rathour Rajeev Singh , Masseron Thomas 
Published: December 2019

ABSTRACT
Barium stars are one of the important probes to understand the origin and evolution of slow neutron-capture process elements in the Galaxy. These are extrinsic stars, where the observed s-process element abundances are believed to have an origin in the now invisible companions that produced these elements at their asymptotic giant branch (AGB) phase of evolution. We have attempted to understand the s-process nucleosynthesis, as well as the physical properties of the companion stars through a detailed comparison of observed elemental abundances of 10 barium stars with the predictions from AGB nucleosynthesis models, FRUITY. For these stars, we have presented estimates of abundances of several elements, C, N, O, Na, Al, α-elements, Fe-peak elements, and neutron-capture elements Rb, Sr, Y, Zr, Ba, La, Ce, Pr, Nd, Sm, and Eu. The abundance estimates are based on high resolution spectral analysis. Observations of Rb in four of these stars have allowed us to put a limit to the mass of the companion AGB stars. Our analysis clearly shows that the former companions responsible for the surface abundance peculiarities of these stars are low-mass AGB stars. Kinematic analysis has shown the stars to be members of Galactic disc population.
AS2-1 TREATMENT OF BENIGN INTRA-AXIAL BRAIN TUMORS IN CHILDREN ASSOCIATED WITH EPILEPSY
Authors: Matsuo Takeshi 
Published: December 2019

Abstract
Low grade neuro-epithelial tumors presenting early-onset epilepsy as the major neurological symptom have recently been categorized as low-grade epilepsy-associated neuro-epithelial tumors, LEAT. Ganglioglioma and dysembryoplastic neuroepithelial tumors consist up to 60% of LEAT. Common characteristics of LEAT being early onset seizure, younger than the age of 15, and temporal lobe localization, its criteria do not include histological or genetic features; LEAT is an independent classification, unrelated to WHO classification.
Treatment for epilepsy associated with LEAT includes medication and surgery. As for drug therapy, most tumor-related seizures are controlled well with anti-epileptic drugs for focal epilepsy such as sodium channel blocker. On the other hand, those who are drug-resistant are candidates for surgical therapy. Because epileptogenic zone mostly exists not in tumor itself but in the marginal brain tissue, pure tumor resection without resection of peripheral epileptogenic zone sometimes fails to achieve satisfactory seizure outcome. Concept of epilepsy surgery is indispensable in pre-operative evaluation and in planning surgical strategy. Related association fibers in addition to five zones, epileptogenic zone, seizure onset zone, irritative zone, symptomatogenic zone and functional deficit zone should be taken into consideration.
Long-term survival is expected in children who underwent total resection of benign tumors. Therefore, good seizure control is crucial in improving activities of daily lives.
GEN-13 FIREWORK PATTERN OF CANCER GENESIS FOR GLIOBLASTOMA, IDH-WILDTYPE
Authors: Yoon Seon-Jin , Park Junseong , Kim Hyun Jung , Lee Joo Ho , Hee Chang Jong , Ho Lee Jeong , Kang Seok-Gu 
Published: December 2019

Abstract
Treatment of Glioblastoma (GBM), IDH-wildtype is a history of sequential failure. The cure for this disease is a distant story, and it is really the emperor of cancer. We believe that GBM should not be considered one of several cancers, and GBM is a cancer that occurs in a special environment called the central nervous system (CNS). What is the biggest difference between other cancers and cancers of the nervous system? It is thought to be neurogenesis. This presentation will review GBM genesis based on neurogensis of CNS. It also explains what the cell of origin is, what somatic mutations occur at the cell of origin, and why these somatic mutations occur. Human glioblastoma (GBM) occurs in a place without cancer tissue, that is, in the subventricular zone and have introduced the name of the firework pattern of cancer genesis, which is a metaphorical representation of the GBM genesis. So far, we have been trying to develop therapeutics focused on bulk tumors. However, in the case of GBM, IDH-wildtype, it has been found that the cell of origin is not in the tumor but is in normal SVZ, so it is now considered that the therapeutic target should also include the cell of origin.
TB-01 HUMAN IPS CELL-DERIVED BRAIN TUMOR MODEL UNCOVERS THE EMBRYONIC STEM CELL SIGNATURE AS A KEY DRIVER IN ATYPICAL TERATOID/RHABDOID TUMOR
Authors: Terada Yukinori , Jo Norihide , Arakawa Yoshiki , Mineharu Yohei , Yamada Yasuhiro , Miyamoto Susumu 
Published: December 2019

Abstract
Atypical teratoid/rhabdoid tumor (AT/RT), which harbors SMARCB1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatments. We established human SMARCB1-deficient pluripotent stem cells (hPSCs), which enabled investigation of the pathogenesis of AT/RT. SMARCB1-deficient hPSCs and neural progenitor-like cells (NPLCs) efficiently gave rise to brain tumors when transplanted into mouse brain. Notably, the emergence of typical rhabdoid cells was significantly enhanced in tumors from SMARCB1-deficient hPSCs. An embryonic stem cell (ESC)-like gene expression signature was more prominent in hPSC-derived tumors when compared with NPLCs-derived tumors. Moreover, mice transplanted with SMARCB1-deficient hPSCs showed poor survival than NPLC-transplanted mice. Activation of the ESC-like signature by the forced expression of reprogramming factors conferred a rhabdoid histology in SMARCB1-deficient NPLC-derived tumors, suggesting that acquisition of the ESC-like signature is responsible for the rhabdoid histology. Consistently, we found activation of the ESC-like gene expression signature and an ESC-like DNA methylation landscape in clinical specimens of AT/RT. Mechanistically, c-MYC expression was sufficient to acquire the ESC-like signature and the rhabdoid histology in SMARCB1-deficient NPLC-derived tumors, which resulted in poor survival. Together, SMARCB1-deficient hPSCs offer the first human model for AT/RT, which uncovered the unappreciated role of the activated ESC-like signature in the poor prognosis and unique histology. Finally, we performed a CRISPR/Cas9 knockout screening to inhibit activation of the ESC-like signature in AT/RT. Our effort identified candidate genes as therapeutic targets, including RAD21, which encodes a key component within the cohesin complex. Notably, chemical inhibition of HDAC8, which indirectly targets the function of cohesin, with simultaneous inhibition of EZH2 efficiently suppressed activation of the ESC-like signature and inhibited the growth of AT/RT cells. Collectively, we propose that the ESC-like signature could be a crucial therapeutic target for AT/RTs with rhabdoid histology.
ACT-13 RESPONSE TO SEIZURE AND TUMOR-PROGRESSION BY TREATMENT WITH PERAMPANEL IN PATIENTS WITH GLIOMAS
Authors: Izumoto Shuichi , Miyauchi Masaru , Watanabe Akira , Murakami Saori , Tsuyuguchi Naohiro , Kato Amami 
Published: December 2019

Abstract

BACKGROUND
Increased extracellular glutamate level activates AMPA type glutamate receptors (AMPA-receptor) and induces seizures. Antagonistic activation of AMPA-receptors inhibits epilepsy and glioma progression in vivo and in vitro studies.

PATIENTS AND METHODS
(1) We tested perampanel (PER), an AMPA-receptor antagonist, in fifteen glioma patients with uncontrolled epilepsy. Seizure response, PER concentration, and tumor volume were assessed. (2) We tested PER in thirteen glioma patients (gr 2- 3 cases, gr 3- 4 cases, and gr 4- 4cases) after the initial treatment of surgery and RT (and CT).

RESULTS
(1) An objective seizure response was observed in 13 analyzed patients (100%) with 8 cases (62%) of seizure-freedom. Median plasma concentration of PER was 232 ng/ml in patients with 4mg/day PER and 518 ng/ml in patients with 8mg/day PER. High intensity lesions of MRI-FLAIR images were assessed volumetrically to analyze the tumor size. The volume reduction was detected during the 6 months period in correlation with the plasma PER levels. (2) All the 13 cases treated with PER after the initial treatment was seizure free. Two cases of gr 4 were died at 18 and 20 months after the surgical treatment. Other 11 cases are survival-free.

CONCLUSION
PER treatment was effective in uncontrolled epilepsy with gliomas. MRI images showed the inhibition of tumor-progression. PER may effective for the inhibition of tumor progression.