bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-similar transport, spin polarization and thermoelectricity in complex silicene structures
Authors: Rodríguez-González R. , Gaggero-Sager L. M. , Rodríguez-Vargas I. 
Published: September 2020

Abstract2D materials open the possibility to study Dirac electrons in complex self-similar geometries. The two-dimensional nature of materials like graphene, silicene, phosphorene and transition-metal dichalcogenides allow the nanostructuration of complex geometries through metallic electrodes, interacting substrates, strain, etc. So far, the only 2D material that presents physical properties that directly reflect the characteristics of the complex geometries is monolayer graphene. In the present work, we show that silicene nanostructured in complex fashion also displays self-similar characteristics in physical properties. In particular, we find self-similar patterns in the conductance, spin polarization and thermoelectricity of Cantor-like silicene structures. These complex structures are generated by modulating electrostatically the silicene local bandgap in Cantor-like fashion along the structure. The charge carriers are described quantum relativistically by means of a Dirac-like Hamiltonian. The transfer matrix method, the Landauer–Büttiker formalism and the Cutler–Mott formula are used to obtain the transmission, transport and thermoelectric properties. We numerically derive scaling rules that connect appropriately the self-similar conductance, spin polarization and Seebeck coefficient patterns. The scaling rules are related to the structural parameters that define the Cantor-like structure such as the generation and length of the system as well as the height of the potential barriers. As far as we know this is the first time that a 2D material beyond monolayer graphene shows self-similar quantum transport as well as that transport related properties like spin polarization and thermoelectricity manifest self-similarity.
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization
Authors: Gottardo Maria F. , Capobianco Carla S. , Sidabra Johanna E. , Garona Juan , Perera Yasser , Perea Silvio E. , Alonso Daniel F. , Farina Hernan G. 
Published: September 2020

AbstractCK2 is a serine/threonine kinase that is overexpressed in breast cancer and its inhibition is associated to reduced tumor growth and disease progression. CIGB-300 is an antitumor peptide with a novel mechanism of action, since it binds to protein kinase CK2 catalytic subunit alpha and to CK2 substrates thus preventing the enzyme activity. Our aim was to evaluate the potential therapeutic benefits of CIGB-300 on breast cancer disease using experimental models with translational relevance. We demonstrated that CIGB-300 reduces breast cancer cell growth in MDA-MB-231, MCF-7 and F3II cells, exerting a pro-apoptotic action and cell cycle arrest. We also found that CIGB-300 decreased cell adhesion, migration and clonogenic capacity of malignant cells. Effect on experimental breast cancer lung metastasis was evaluated after surgical removal of primary F3II tumors or after tail vein injection of tumor cells, also we evaluated CIGB-300 effect on spontaneous lung metastasis in an orthotopic model. Systemic CIGB-300 treatment inhibited breast cancer colonization of the lung, reducing the size and number of metastatic lesions. The present preclinical study establishes for the first time the efficacy of CIGB-300 on breast cancer. These encouraging results suggest that CIGB-300 could be used for the management of breast cancer as an adjuvant therapy after surgery, limiting tumor metastatic spread and thus protecting the patient from distant recurrence.
Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III
Authors: Mohamed Amal Ahmed , Shousha Wafaa Gh. , Zaki Moushira Erfan , El-Bassyouni Hala T. , El-Hanafi Hadeel , Abdo Sara M. 
Published: September 2020

Abstract
Background: Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Methods: Out of 130 females, 70 were categorized into three obesity groups: Class I, body mass index (BMI) 30–34.9 kg/m2; Class II, BMI 35–39.9 kg/m2 and Class III BMI ≥ 40 kg/m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin (IL) 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1 (sVCAM-1) were assessed among participants. Results: In all three classes of obesity, significant increase (P &lt;0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the three obesity groups. TNF-α levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group. Conclusion: Based on individuals’ BMI, serum levels of TNF-α, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity.
Assistierte Peritonealdialyse für den geriatrischen Patienten
Authors: Bergner Franziska 
Published: September 2020

ZUSAMMENFASSUNGDer vorliegende Beitrag beschreibt die assistierte Peritonealdialyse (aPD). Er gibt einen Überblick darüber, wie sich die Lebensqualität bei den älteren und multimorbiden Patienten verbessern kann. Dabei wird beschrieben, wie sich besonders der betagte Patient an der Hämodialyse fühlt und welche Wünsche er hinsichtlich seiner Behandlung hat. Der zweite Teil des Artikels bezieht sich auf die Vorteile seitens des Patienten, welche sich aus der assistierten Peritonealdialyse für ihn ergeben. Der dritte Abschnitt erklärt die Organisation und Umsetzung dieser Behandlung. Ziel soll es sein, die assistierte Peritonealdialyse mehr in den Vordergrund zu rücken.
AKI-Alerts
Authors: Khadzhynov Dmytro , Schmidt Danilo , Schmidt-Ott Kai M. 
Published: September 2020

ZUSAMMENFASSUNGIn Anbetracht der hohen Inzidenz und Mortalität von AKI (Acute Kidney Injury) sowie der unzureichenden Erkennung von AKI-Episoden im klinischen Alltag, sind AKI-Frühwarnsysteme ein einfacher und naheliegender Ansatz, um die Versorgung von AKI-Patienten zu verbessern. Obwohl AKI-Alerts in prospektiven Studien bisher keine konsistenten Effekte auf die Krankenhausmortalität zeigten, gibt es deutliche Hinweise, dass sie klinische Prozesse sowie Surrogat-Endpunkte verbessern und somit zur Qualitätsverbesserung im Krankenhaus beitragen. Dabei scheint insbesondere eine Kopplung des Alarmsystems an standardisierte klinische Prozesse entscheidend zu sein. Da diese Prozesse krankenhaus- und abteilungsspezifische Besonderheiten aufweisen und sich derzeit in der Abwesenheit einer überzeugenden Studienlage nicht universell definieren lassen, sollten Kliniken, die AKI-Alert-Systeme implementieren, die Effektivität dieser Maßnahme systematisch evaluieren.
High-energy Flux Density Extracorporeal Shock-wave Therapy Versus
Therapeutic Steroid Injection in Costochondritis: A Single-Blind, Randomised
Controlled Study
Authors: Çiftçi Halil , Gezginaslan Ömer 
Published: September 2020

Abstract
Background This study aims to investigate the effects of extracorporeal
shock-wave therapy (ESWT) and intra-articular steroid injection (IASI) on pain,
depression, quality of life and pressure pain threshold (PPT) in patients with
costochondritis.
Methods A total of 67 patients diagnosed with costochondritis were
included. Patients were divided into 2 groups. Group 1 (n=34) received
high-energy flux density (H-ESWT)
(> 0.28 mJ/mm2) for a total of 7
sessions at 3-day intervals. Group 2 (n=33) received IASI twice at
2-week intervals. At baseline and one month after treatment, Visual Analog Scale
(VAS), Short Form-36 (SF-36), Pittsburgh Sleep Quality Index (PSQI), Beck
Depression Inventory (BDI) scores and PPT values were compared.
Results There was a statistically significant decrease in VAS scores
after treatment compared with baseline scores in both groups. The PPT and SF-36
subscale scores were also statistically significantly higher (p<0.05).
After treatment, VAS and PPT showed a significantly better improvement in Group
1 compared to Group 2. There was a significant correlation between VAS and SF-36
physical functioning as well as pain subscales in Group 1 and a significant
correlation between VAS and SF-36 physical functioning in Group 2.
Conclusions Our data suggest that both treatments H-ESWT and IASI are
effective in costochondritis patients. Of note, H-ESWT has a stronger effect on
pain and PPT scores.
Erfassung ärztlicher Arbeitszeit in einer internistischen
Klinik mit rheumatologisch-nephrologischem Profil
Authors: Unger Leonore , Nestler Olaf , Hillger Christiane , Marczynski Cornelia , Teige Robin , Kayser Marten 
Published: September 2020

ZusammenfassungUnter den Bedingungen zunehmender Arbeitsverdichtung ist der ärztliche
Stellenschlüssel in deutschen Krankenhäusern immer wieder
Ausgangspunkt für Konflikte zwischen leitenden Ärzten und
Verwaltung bzw. Träger. Bisher gab es keine publizierten Grundlagen
für die Bemessung ärztlicher Vollzeitkräfte (VK)
für internistische Normalstationen. Anhand der erfassten Arbeitsaufgaben
im zeitlichen Kontext konnte in der vorliegenden Arbeit errechnet werden, dass
zur Erfüllung des Versorgungsauftrages für einen internistischen
Patienten auf einer rheumatologisch-nephrologischen Normalstation ein
Assistenzarzt/Facharzt für 7 Betten und ein Oberarzt für
24 Betten geplant werden müssen. Gesprächs- und Recherche-
Leistungen, Ausbildung und Supervision, die Teilnahme am Dienstsystem,
Dokumentationsaufwand und Fortbildungsverpflichtungen bilden sich nicht
adäquat im derzeitig gültigen DRG- System ab.
Efficacy and safety of gastric exposed endoscopic full-thickness resection without laparoscopic assistance: a systematic review
Authors: Granata Antonino , Martino Alberto , Amata Michele , Ligresti Dario , Tuzzolino Fabio , Traina Mario 
Published: September 2020

Abstract
Background and study aims Exposed endoscopic full-thickness resection (Eo-EFTR) without laparoscopic assistance is a minimally invasive natural orifice transluminal endoscopic surgery (NOTES) technique that has shown promising efficacy and safety in resection of gastric submucosal tumors (G-SMTs) arising from muscularis propria (MP). However, data on the efficacy and safety of gastric Eo-EFTR mostly come from relatively small retrospective studies and concern regarding its use still exists. The aim of our systematic review was to assess the efficacy and safety of gastric Eo-EFTR without laparoscopic assistance.
Methods A detailed MEDLINE and EMBASE search was performed for papers published from January 1998 to November 2019 and reporting on gastric Eo-EFTR without laparoscopic assistance. The search strategy used the terms “endoscopic full thickness resection” and “gastric” or “stomach”. The primary outcomes were complete resection and surgical conversion rates. The secondary outcomes were overall major adverse events, delayed bleeding, delayed perforation, peritonitis, abdominal abscess and/or abdominal infection and successful Eo-EFTR.
Results Fifteen Asian studies were included in our final review, providing data on 750 Eo-EFTR-treated G-SMTs. The per-lesion rate of complete resection and surgical conversion were 98.8 %\0.8 %, respectively. The per-lesion rate of major adverse events, delayed bleeding, delayed perforation and peritonitis, abdominal abscess and/or abdominal infection was 1.6 %\0.5 %\0.1 %\0.9 %, respectively. The per-lesion rate of successful Eo-EFTR (i. e. complete tumor resection and effective endoscopic defect closure) was 98.3 %.
Conclusions Eo-EFTR without laparoscopic assistance appears to be highly effective and safe NOTES for removing deep G-SMTs, particularly those arising from MP layer.
Volatile organic compounds in bile can distinguish pancreatic cancer from chronic pancreatitis: a prospective observational study
Authors: Navaneethan Udayakumar , Spencer Chad , Zhu Xiang , Vargo John J. , Grove David , Dweik Raed A. 
Published: September 2020

Abstract
Background Early and accurate diagnosis of pancreatic cancer is important. Our aim was to identify potential volatile organic compounds (VOCs) in the bile that can help distinguish pancreatic cancer from chronic pancreatitis.
Methods In this prospective observational study, bile was aspirated from patients undergoing endoscopic retrograde cholangiopancreatography for chronic pancreatitis and pancreatic cancer, and the gaseous headspace was analyzed using mass spectrometry.
Results The study included a discovery cohort of 57 patients (46 pancreatic cancer, 11 chronic pancreatitis) and a validation cohort of 31 patients (19 and 12, respectively). Using logistic regression analysis, the model [0.158 × age + 9.747 × log (ammonia) – 3.994 × log (acetonitrile) + 5.044 × log (trimethylamine) – 30.23] successfully identified patients with pancreatic cancer with a sensitivity of 93.5 % and specificity of 100 % (likelihood ratio 40.9, area under the curve 0.98, 95 % confidence interval 0.95 – 1.00). The diagnostic accuracy of this model was confirmed in the second independent validation cohort.
Conclusion The measurement of VOCs in bile helped to accurately distinguish pancreatic cancer from chronic pancreatitis.
Usability Evaluation of a Distributed User Interface Application for Visuomotor Organization Assessment
Authors: Cuerda Cristian , Romero-Ayuso Dulce , Gallud Jose A. , Morales Carmen , Tesoriero Ricardo , Triviño-Juarez Jose-Matias , Fardoun Habib M. 
Published: September 2020

Abstract
Background This article describes the development and evaluation of a distributed user interface (DUI) application to assess visuomotor organization ability. This application enables therapists to evaluate the acquired brain injury (ABI) on patients, and patients, to perform the assessment on a touch screen while therapists can observe the assessment process in real time on a separated monitor without interfering patients during the process as in traditional methodologies employing physical elements.
Objectives The main goal of this research is the evaluation of the quality in use of DUIs in the Pegboard Construction assessment with patients with ABI from the therapist perspective in the area of occupational therapy.
Methods To evaluate our system, we have performed a usability evaluation following the ISO/IEC 25010 and ISO/IEC 25062 standards to evaluate software usability and quality and it was conducted in collaboration with therapists and psychologists that have previously worked with people with ABI in diagnostic and assessment tasks.
Results We show the results of the evaluation collected in a table that shows the completeness rate for each user for both, assisted (i.e., the percentage of tasks where participants performed with test director assistance) and unassisted tasks (i.e., the percentage of tasks where participants completed tasks autonomously), the total time participants required to complete proposed tasks, the number of mistakes participants performed during the session, and the number of assists they required to finish proposed tasks. In addition, we also evaluated the user satisfaction regarding our application using the system usability scale.
Conclusion The use of information technologies in this field enables therapists to perform these evaluations in a simpler, efficient, and automated way. This proposal enables patients to perform the assessment as it is performed traditionally using paper providing them with a touch screen in which they can easily insert a set of pins into the holes. The usability evaluation of the proposal meets the appropriate design standards for applications of this type, and this is demonstrated by the high degree of satisfaction of the participants.
Enhancing Traceability in Clinical Research Data through a Metadata Framework
Authors: Hume Samuel , Sarnikar Surendra , Noteboom Cherie 
Published: September 2020

Abstract
Background The clinical research data lifecycle, from data collection to analysis results, functions in silos that restrict traceability. Traceability is a requirement for regulated clinical research studies and an important attribute of nonregulated studies. Current clinical research software tools provide limited metadata traceability capabilities and are unable to query variables across all phases of the data lifecycle.
Objectives To develop a metadata traceability framework that can help query and visualize traceability metadata, identify traceability gaps, and validate metadata traceability to improve data lineage and reproducibility within clinical research studies.
Methods This research follows the design science research paradigm where the objective is to create and evaluate an information technology (IT) artifact that explicitly addresses an organizational problem or opportunity. The implementation and evaluation of the IT artifact demonstrate the feasibility of both the design process and the final designed product.
Results We present Trace-XML, a metadata traceability framework that extends standard clinical research metadata models and adapts graph traversal algorithms to provide clinical research study traceability queries, validation, and visualization. Trace-XML was evaluated using analytical and qualitative methods. The analytical methods show that Trace-XML accurately and completely assesses metadata traceability within a clinical research study. A qualitative study used thematic analysis of interview data to show that Trace-XML adds utility to a researcher's ability to evaluate metadata traceability within a study.
Conclusion Trace-XML benefits include features that (1) identify traceability gaps in clinical study metadata, (2) validate metadata traceability within a clinical study, and (3) query and visualize traceability metadata. The key themes that emerged from the qualitative evaluation affirm that Trace-XML adds utility to the task of creating and assessing end-to-end clinical research study traceability.
Reconsidering NMIHBA Core Features: Macrocephaly Is Not a So Unusual Sign in PRUNE1-Related Encephalopathy
Authors: Battini Roberta , Bertini Enrico , Milone Roberta , Aiello Chiara , Pasquariello Rosa , Rubegni Anna , Santorelli Filippo Maria 
Published: September 2020

Abstract
PRUNE1-related disorders manifest as severe neurodevelopmental conditions associated with neurodegeneration, implying a differential diagnosis at birth with static encephalopathies, and later with those manifesting progressive brain damage with the involvement of both the central and the peripheral nervous system.Here we report on another patient with PRUNE1 (p.Asp106Asn) recurrent mutation, whose leukodystrophy, inferior olives hyperintensity, and macrocephaly led to the misleading clinical suspicion of Alexander disease. Clinical features, together with other recent descriptions, suggest avoiding the term “microcephaly” in defining this disorder that could be renamed “neurodevelopmental disorder with progressive encephalopathy, hypotonia, and variable brain anomalies” (NPEHBA).
Impact of Income on Perceived Stress, Coping, and Family Functioning in Indian Females with Pseudoseizures
Authors: Mehta Richa , Mittal Anuj , Singh Dweep , Patel Chirag 
Published: September 2020

Abstract
Background Pseudoseizures are paroxysmal alterations in behavior that resemble epileptic seizures but are without any organic cause. Stress, coping, and family functioning are contributing factors in the development and maintenance of pseudoseizures. Literature has found patients with pseudoseizures to belong to lower economic strata; however, no study has directly looked at the impact of income on the core contributing and maintaining factors of pseudoseizures.
Aim This article studies the impact of income on perceived stress, coping, and family functioning in females with pseudoseizures.
Materials and Methods Ninety-one females with pseudoseizures were recruited from the psychiatry department of a tertiary care hospital in New Delhi, India. Each participant completed the Perceived Stress Scale, Ways of Coping Questionnaire, and McMasters Family Assessment Device–General Functioning Scale. Other sociodemographic variables including per capita family monthly income, level of education, area of residence, and employment status were also recorded.
Results Planful Problem Solving and Positive Reappraisal were positively associated with per capita income, while escape-avoidance coping was found to be negatively associated with per capita income. Results also showed a statistically significant negative relationship between perceived stress scores, family functioning, and per capita family income, with income having the highest contribution to family functioning in females with dissociative convulsions.
Conclusion Income was a significant contributor to perceived stress, coping processes, and family functioning. Therefore, high levels of perceived stress, greater familial dysfunction, and maladaptive coping had negative impacts on the outcome of female patients with pseudoseizures belonging to lower income group.
Supraclavicular Flap for Large Anterior Chest Wall Defects–A Road Less Travelled
Authors: More Amrita , Sivakumar Anoop , Gaurav Gupta K 
Published: September 2020

AbstractLarge upper central chest wall defects are a reconstructive challenge. The commonly described flaps for this area do not provide very large skin paddle, and free tissue transfer remains the only option for large skin defects. Supraclavicular flap as a local flap is widely used for head and neck reconstruction and has been described for upper chest wall defects earlier. We have used nonislanded supraclavicular flap for reconstruction of two cases of large chest wall defects, which would otherwise need free tissue transfer, single flap in one case and bilateral flaps in the other. It is easy to do and has minimal morbidity. Supraclavicular flap offers a simple solution for large skin defects of the upper central chest wall and is especially useful in patients with high-operative risk and guarded prognosis.