bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-Atom Cobalt-Based Electrochemical Biomimetic Uric Acid Sensor with Wide Linear Range and Ultralow Detection Limit
Authors: Hu Fang Xin , Hu Tao , Chen Shihong , Wang Dongping , Rao Qianghai , Liu Yuhang , Dai Fangyin , Guo Chunxian , Yang Hong Bin , Li Chang Ming 
Published: October 2020

AbstractUric acid (UA) detection is essential in diagnosis of arthritis, preeclampsia, renal disorder, and cardiovascular diseases, but it is very challenging to realize the required wide detection range and low detection limit. We present here a single-atom catalyst consisting of Co(II) atoms coordinated by an average of 3.4 N atoms on an N-doped graphene matrix (A–Co–NG) to build an electrochemical biomimetic sensor for UA detection. The A–Co–NG sensor achieves a wide detection range over 0.4–41,950 μM and an extremely low detection limit of 33.3 ± 0.024 nM, which are much better than previously reported sensors based on various nanostructured materials. Besides, the A–Co–NG sensor also demonstrates its accurate serum diagnosis for UA for its practical application. Combination of experimental and theoretical calculation discovers that the catalytic process of the A–Co–NG toward UA starts from the oxidation of Co species to form a Co3+–OH–UA*, followed by the generation of Co3+–OH + *UA_H, eventually leading to N–H bond dissociation for the formation of oxidized UA molecule and reduction of oxidized Co3+ to Co2+ for the regenerated A–Co–NG. This work provides a promising material to realize UA detection with wide detection range and low detection limit to meet the practical diagnosis requirements, and the proposed sensing mechanism sheds light on fundamental insights for guiding exploration of other biosensing processes.
Soziale Probleme, diskursive Praxis und das Problem mit der Kriminologie
Authors: Menzel Birgit , Wehrheim Jan 
Published: October 2020

ZusammenfassungDer Aufsatz befasst sich mit Gemeinsamkeiten zwischen der Soziologie sozialer Probleme und der Kriminologie, insbesondere mit der Kontroverse um ätiologische und konstruktivistische Perspektiven auf soziale Probleme und abweichendes Verhalten. Am Beispiel aktueller Debatten über sexualisierte Gewalt werden die Defizite ätiologischer Analysen aufgezeigt. Der Beitrag kommt zu dem Schluss, dass die Soziologie sozialer Probleme ebenso wie die Kriminologie in einer Soziologie sozialer Problematisierungen und sozialer Kontrolle aufgeht.
Quantitative Benefit–Risk Assessment: State of the Practice Within Industry
Authors: Smith Meredith Y. , van Til Janine , DiSantostefano Rachael L. , Hauber A. Brett , Marsh Kevin 
Published: October 2020

Abstract
Background
Benefit–risk assessments for medicinal products and devices have advanced significantly over the past decade. The purpose of this study was to characterize the extent to which the life sciences industry is utilizing quantitative benefit–risk assessment (qBRA) methods.

Methods
Semi-structured interviews were conducted with a sample of industry professionals working in drug and/or medical device benefit–risk assessments (n = 20). Questions focused on the use, timing, and impact of qBRA; implementation challenges; and future plans. Interviews were recorded, transcribed, and coded for thematic analysis.

Results
While most surveyed companies had applied qBRA, application was limited to a small number of assets—primarily to support internal decision-making and regulatory submissions. Positive impacts associated with use included improved team decision-making and communication. Multi-criteria decision analysis and discrete choice experiment were the most frequently utilized qBRA methods. A key challenge of qBRA use was the lack of clarity regarding its value proposition. Championing by senior company leadership and receptivity of regulators to such analyses were cited as important catalysts for successful adoption of qBRA. Investment in qBRA methods, via capability building and pilot studies, was also under way in some instances.

Conclusion
qBRA application within this sample of life sciences companies was widespread, but concentrated in a small fraction of assets. Its use was primarily for internal decision-making or regulatory submissions. While some companies had plans to build further capacity in this area, others were waiting for further regulatory guidance before doing so.
Damage evolution in AA2124/SiC metal matrix composites under tension with consecutive unloadings
Authors: Rutecka A. , Kursa M. , Pietrzak K. , Kowalczyk-Gajewska K. , Makowska K. , Wyszkowski M. 
Published: October 2020

AbstractNonlinear properties of metal matrix composites (MMCs) are studied. The research combines results of loading–unloading tensile tests, microstructural observations and numerical predictions by means of micromechanical mean-field models. AA2124/SiC metal matrix composites with SiC particles, produced by the Aerospace Metal Composites Ltd. (AMC) are investigated. The aluminum matrix is reinforced with 17% and 25% of SiC particles. The best conditions to evaluate the current elastic stiffness modulus have been assessed. Tensile tests were carried out with consecutive unloading loops to obtain actual tensile modulus and study degradation of elastic properties of the composites. The microstructure examination by scanning electron microscopy (SEM) showed a variety of phenomena occurring during composite deformation and possible sources of elastic stiffness reduction and damage evolution have been indicated. Two micromechanical approaches, the incremental Mori–Tanaka (MT) and self-consistent (SC) schemes, are applied to estimate effective properties of the composites. The standard formulations are extended to take into account elasto-plasticity and damage development in the metal phase. The method of direct linearization performed for the tangent or secant stiffness moduli is formulated. Predictions of both approaches are compared with experimental results of tensile tests in the elastic–plastic regime. The question is addressed how to perform the micromechanical modelling if the actual stress–strain curve of metal matrix is unknown.
A comparative assessment of flutter prediction techniques
Authors: Sudha U.P.V. , Deodhare G.S. , Venkatraman K. 
Published: October 2020

ABSTRACTTo establish flutter onset boundaries on the flight envelope, it is required to determine the flutter onset dynamic pressure. Proper selection of a flight flutter prediction technique is vital to flutter onset speed prediction. Several methods are available in literature, starting with those based on velocity damping, envelope functions, flutter margin, discrete-time Autoregressive Moving Average (ARMA) modelling, flutterometer and the Houbolt–Rainey algorithm. Each approach has its capabilities and limitations. To choose a robust and efficient flutter prediction technique from among the velocity damping, envelope function, Houbolt–Rainey, flutter margin and auto-regressive techniques, an example problem is chosen for their evaluation. Hence, in this paper, a three-degree-of-freedom model representing the aerodynamics, stiffness and inertia of a typical wing section is used(1). The aerodynamic, stiffness and inertia properties in the example problem are kept the same when each of the above techniques is used to predict the flutter speed of this aeroelastic system. This three-degree-of-freedom model is used to generate data at speeds before initiation of flutter, during flutter and after occurrence of flutter. Using these data, the above-mentioned flutter prediction methods are evaluated and the results are presented.
On the Evaluation of the Ambulance Capacity of the Asian Side of Istanbul in the Case of a Serious Earthquake
Authors: Pınarbaşı Aysun , Babaqi Tareq , Vizvári Béla 
Published: October 2020

ABSTRACTObjectives:The purpose of this study is to analyze a strategy for the assignment and transportation of injured patients to hospital to decrease the demand on transportation, in both predisaster and postdisaster periods, on the Anatolian side of Istanbul.Methods:Two approaches are used in this study: a Voronoi diagram, and a heuristic approach to the problem of scheduling. A Voronoi diagram is used to divide the city into 74 regions, where each hospital has a certain region of responsibility. The transportation strategy of 1 hospital is modeled by minimizing the makespan (ie, the maximal completion time) and the work-in-process, which are used as different objectives in scheduling theory.Results:The total waiting time of 100 injured people was minimized to 13,036 min when a total of 3 vehicles was used in the studied region, on the Asian side of Istanbul. The transportation capacity and total operating capacity of the hospitals should be approximately equal.Conclusions:The people of Istanbul will be in a safer position if the suggested measures are implemented. This is an important consideration, as Istanbul is situated in a region where serious earthquakes are possible at any moment.
Cultural Gaslighting
Authors: Ruíz Elena 
Published: October 2020

AbstractThis essay frames systemic patterns of mental abuse against women of color and Indigenous women on Turtle Island (North America) in terms of larger design-of-distribution strategies in settler colonial societies, as these societies use various forms of social power to distribute, reproduce, and automate social inequalities (including public health precarities and mortality disadvantages) that skew socioeconomic gain continuously toward white settler populations and their descendants. It departs from traditional studies in gender-based violence research that frame mental abuses such as gaslighting—commonly understood as mental manipulation through lying or deceit—stochastically, as chance-driven, interpersonal phenomena. Building on structural analyses of knowledge in political epistemology (Dotson 2012a; Berenstain 2016), political theory (Davis and Ernst 2017), and Indigenous social theory (Tuck and Yang 2012), I develop the notion ofcultural gaslightingto refer to the social and historical infrastructural support mechanisms that disproportionately produce abusive mental ambients in settler colonial cultures in order to further the ends of cultural genocide and dispossession. I conclude by proposing a social epidemiological account of gaslighting that a) highlights the public health harms of abusive ambients for minority populations, b) illuminates the hidden rules of social structure in settler colonial societies, and c) amplifies the corresponding need for structural reparations.
Sidestepping primary reform: political action in response to institutional change
Authors: Hill Seth J. 
Published: October 2020

AbstractMany believe primary elections distort representation in American legislatures because unrepresentative actors nominate extremist candidates. Advocates have reformed primaries to broaden voter participation and increase representation. Empirical evidence, however, is quite variable on the effects of reform. I argue that when institutional reform narrows one pathway of political influence, aggrieved actors take political action elsewhere to circumvent reform. I use a difference-in-differences design in the American states and find that although changing primary rules increases primary turnout, campaign contributions also increase with reform. Implementing nonpartisan primaries and reforming partisan primaries lead to estimated 9 and 21 percent increases in individual campaign contributions per cycle. This suggests actors substitute action across avenues of political influence to limit effects of institutional reform.
Adherence to recommended intake of pulses and related factors in university students in the UniHcos project
Authors: Morales-Suárez-Varela María , Amezcua-Prieto Carmen , Peraita-Costa Isabel , Ayan Pérez Carlos , Valero Juan Luis Félix , Ortiz-Moncada Rocío , Almaraz Gómez Ana , Alguacil Ojeda Juan , Delgado Rodriguez Miguel , Blázquez Abellán Gemma , Jesús Cabero María , Jiménez Mejías Eladio , Llopis-Morales Agustín , Bueno Cavanillas Aurora , Fernández-Villa Tania ,   Grupo de Investigación UniHcos
Published: October 2020

AbstractPulses such as peas, beans or lentils are one of the most complete foods at the nutritional level; however, they are one of the most often neglected foods in the diets of university students. Entrance to university translates into a major lifestyle change for many young people, and the habits acquired or cemented at this time will remain into adulthood. The objective of this study is to analyse the association between personal/sociodemographic factors, dietary intake of other food groups and the consumption of pulses in first-year university students. This cross-sectional study is part of the UniHcos project, a multicentre study of multipurpose prospective cohorts in eleven Spanish universities. Data from 9862 university students were collected through an online self-questionnaire completed by all students who met the selection criteria and agreed to participate in the project during the 2011–2018 academic years. Of students, 75·8 % presented an inadequate (≤2 times/week) consumption of pulses. Living outside the family home in either a student residence (OR 0·76; 95 % CI 0·69, 0·84) or rental (OR 0·81; 95 % CI 0·70, 0·95) decreased the compliance with recommendations on the consumption of pulses. Low consumption of pulses is seemingly not restricted to a specific profile or dietary pattern among university students, and no specific focus group for intervention can be identified. Policies promoting the consumption of pulses among the university population as a whole are necessary to increase compliance rates with the dietary recommendations.
Changes in land use affect anuran helminths in the South Brazilian grasslands
Authors: Portela A.A.B. , dos Santos T.G. , dos Anjos L.A. 
Published: October 2020

AbstractDegradation and habitat loss of natural grasslands in Southern Brazil has a negative impact on native organisms, potentially including the composition of anuran helminth communities. Here, we characterized the richness, abundance, taxonomic composition, prevalence and intensity of helminth infection in four anuran species. Host anurans were collected in 34 ponds (19 in native grasslands with livestock and 15 in agricultural cultivation) from the highland grasslands in the Brazilian states of Santa Catarina and Paraná. Our results showed a significant difference between native grasslands with livestock and agricultural cultivation regarding the structure of helminth communities for the hostsAplastodiscus perviridisandPseudis cardosoi. We also found a greater prevalence and intensity of infection in anurans in areas of agricultural cultivation than in native grasslands with livestock. We found that the environmental descriptors (local and landscape) seem to explain most of the differences in anuran parasitism recorded between native grasslands with livestock and agricultural areas. Thus, we emphasized that the loss of grassy habitat due to conversion to agricultural cultivation can alter helminth communities in anurans, with further work needed to understand the mechanisms involved.
The Household Benefit Cap: understanding the restriction of benefit income in Britain
Authors: GROVER CHRIS 
Published: October 2020

AbstractBritain’s Household Benefit Cap restricts the amount of benefit income unemployed households can receive. In this article, it is examined using material held at the UK’s National Archives recording debates about a proposal to introduce a similar policy – a benefit limit – in the first Thatcher Conservative government elected in 1979. It was rejected, but the Household Benefit Cap was introduced three decades later. The article locates debates about, and the practice of restricting benefit income, in perennial social security concerns with the financial incentive to do waged work. The article argues that while there are material differences that help explain the different policy outcomes in 1980 and 2010, they can primarily be explained by changing ideas about the roles of social security policy, including the development of the ‘incentive paradigm’ concerned with manipulating behaviour; a loss of concern with the hardship that would come with the introduction of a benefit restriction and a view that institutions other than the state are better placed to address poverty and buttress work incentives.
The NICE MEDLINE and Embase (Ovid) health apps search filters: development of validated filters to retrieve evidence about health apps
Authors: Ayiku Lynda , Hudson Thomas , Glover Sarah , Walsh Nicola , Adams Rachel , Deane Jemma , Finnegan Amy 
Published: October 2020

Abstract

Objectives
Health apps are software programs that are designed to prevent, diagnose, monitor, or manage conditions. Inconsistent terminology for apps is used in research literature and bibliographic database subject headings. It can therefore be challenging to retrieve evidence about them in literature searches. Information specialists at the United Kingdom's National Institute for Health and Care Excellence (NICE) have developed novel validated search filters to retrieve evidence about apps from MEDLINE and Embase (Ovid).

Methods
A selection of medical informatics journals was hand searched to identify a “gold standard” (GS) set of references about apps. The GS set was divided into a development and validation set. The filters’ search terms were derived from and tested against the development set. An external development set containing app references from published NICE products was also used to inform the development of the filters. The filters were then validated using the validation set. Target recall was >90 percent. The filters’ overall recall, specificity, and precision were calculated using all the references identified from the hand search.

Results
Both filters achieved 98.6 percent recall against their validation sets. Overall, the MEDLINE filter had 98.8 percent recall, 71.3 percent specificity, and 22.6 percent precision. The Embase filter had 98.6 percent recall, 74.9 percent specificity, and 24.5 percent precision.

Conclusions
The NICE health apps search filters retrieve evidence about apps from MEDLINE and Embase with high recall. They can be applied to literature searches to retrieve evidence about the interventions by information professionals, researchers, and clinicians.
THE EFFECT OF LEARNING CONTEXT ON L2 LISTENING DEVELOPMENT
Authors: Yu Xiaoru , Janse Esther , Schoonen Rob 
Published: October 2020

AbstractLittle research has been done on the effect of learning context on L2 listening development. Motivated by DeKeyser’s (2015) skill acquisition theory of second language acquisition, this study compares L2 listening development in study abroad (SA) and at home (AH) contexts from both language knowledge and processing perspectives. One hundred forty-nine Chinese postgraduates studying in either China or the United Kingdom participated in a battery of listening tasks at the beginning and at the end of an academic year. These tasks measure auditory vocabulary knowledge and listening processing efficiency (i.e., accuracy, speed, and stability of processing) in word recognition, grammatical processing, and semantic analysis. Results show that, provided equal starting levels, the SA learners made more progress than the AH learners in speed of processing across the language processing tasks, with less clear results for vocabulary acquisition. Studying abroad may be an effective intervention for L2 learning, especially in terms of processing speed.
MEASURING LONGITUDINAL WRITING DEVELOPMENT USING INDICES OF SYNTACTIC COMPLEXITY AND SOPHISTICATION
Authors: Kyle Kristopher , Crossley Scott , Verspoor Marjolijn 
Published: October 2020

AbstractMeasures of syntactic complexity such as mean length of T-unit have been common measures of language proficiency in studies of second language acquisition. Despite the ubiquity and usefulness of such structure-based measures, they could be complemented with measures based on usage-based theories, which focus on the development of not just syntactic forms but also form-meaning pairs, called constructions (Ellis, 2002). Recent cross-sectional research (Kyle & Crossley, 2017) has indicated that indices related to usage-based characteristics of verb argument construction (VAC) use may be better indicators of writing proficiency than structure-based indices of syntactic complexity. However, because cross-sectional studies can only show general trends across proficiency benchmarks, it is important to test these findings in individuals over time (Lowie & Verspoor, 2019). Thus, this study investigates the developmental trajectories of second language learners of English across two academic years with regard to syntactic complexity and VAC sophistication.
A systematic review of unsupervised approaches to grammar induction
Authors: Muralidaran Vigneshwaran , Spasić Irena , Knight Dawn 
Published: October 2020

AbstractThis study systematically reviews existing approaches to unsupervised grammar induction in terms of their theoretical underpinnings, practical implementations and evaluation. Our motivation is to identify the influence of functional-cognitive schools of grammar on language processing models in computational linguistics. This is an effort to fill any gap between the theoretical school and the computational processing models of grammar induction. Specifically, the review aims to answer the following research questions: Which types of grammar theories have been the subjects of grammar induction? Which methods have been employed to support grammar induction? Which features have been used by these methods for learning? How were these methods evaluated? Finally, in terms of performance, how do these methods compare to one another? Forty-three studies were identified for systematic review out of which 33 described original implementations of grammar induction; three provided surveys and seven focused on theories and experiments related to acquisition and processing of grammar in humans. The data extracted from the 33 implementations were stratified into 7 different aspects of analysis: theory of grammar; output representation; how grammatical productivity is processed; how grammatical productivity is represented; features used for learning; evaluation strategy and implementation methodology. In most of the implementations considered, grammar was treated as a generative-formal system, autonomous and independent of meaning. The parser decoding was done in a non-incremental, head-driven fashion by assuming that all words are available for the parsing model and the output representation of the grammar learnt was hierarchical, typically a dependency or a constituency tree. However, the theoretical and experimental studies considered suggest that a usage-based, incremental, sequential system of grammar is more appropriate than the formal, non-incremental, hierarchical view of grammar. This gap between the theoretical as well as experimental studies on one hand and the computational implementations on the other hand should be addressed to enable further progress in computational grammar induction research.