bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primitive recursion in the abstract
Authors: Leivant Daniel , Marion Jean-Yves 
Published: January 2020

AbstractRecurrence can be used as a function definition schema for any nontrivial free algebra, yielding the same computational complexity in all cases. We show that primitive-recursive computing is in fact independent of free algebras altogether, and can be characterized by a generic programming principle, namely the control of iteration by the depletion of finite components of the underlying structure.
Embedding technological transformation: the welfare state and citizen attitudes toward technology
Authors: Lim Sijeong 
Published: January 2020

AbstractMuch scholarly attention has been given to the potentially disruptive distributional implications of new technologies in labor markets. Less explored is the way citizens as socially embedded individuals perceive and respond to technological transformation. This study fills this gap by exploring how welfare state institutions shape and are shaped by citizens’ perceptions of technological transformation. My analysis covering over 50 developed and developing countries finds that welfare state generosity is associated with a greater acceptance of technological change. I also provide evidence consistent with the expectation that labor market interventions of the welfare state have the potential to reduce the skill cleavage over technological transformation by mitigating the insecurity faced by the low-skilled. Additionally, citizens embracing technological transformation are more supportive of the welfare state than techno-skeptics are.
The Ductile‐to‐Brittle Transition Recorded in the Balmuccia Peridotite Body, Italy: Ambient Temperature for the Onset of Seismic Rupture in Mantle Rocks
Authors: Ueda Tadamasa , Obata Masaaki , Ozawa Kazuhito , Shimizu Ichiko 
Published: January 2020

AbstractTo constrain the conditions of the brittle‐ductile transition in peridotite, we studied the deformation sequence of a small‐displacement fault system developed in the Balmuccia peridotite body, northern Italy. The ambient pressure‐temperature conditions of the deformation were estimated using equilibrium mineral assemblages and mineral compositions. Fault‐related deformed rocks, including pseudotachylytes, cataclasites, and mylonites, were classified into three groups according to the metamorphic facies at the time of their formation: Group 1 consists of mylonites, cataclasites, and pseudotachylytes of the spinel‐lherzolite facies; Group 2 consists of cataclasite and pseudotachylyte, but no mylonite, of the plagioclase‐lherzolite facies; and Group 3 consists of cataclasite and pseudotachylyte of a lower‐grade hydrous facies. Cataclasite of the spinel‐lherzolite facies coeval with fault‐vein pseudotachylyte was identified for Group 1 and ambient temperature of the earthquake was determined by applying geothermometers to the mylonite and cataclasite. Among the deformed rocks of the spinel‐lherzolite facies (Group 1), mylonite is truncated by veins of pseudotachylyte. However, the mineral compositions of the mylonite and the cataclasite associated with the pseudotachylyte are essentially identical, yielding a temperature for the ductile‐to‐brittle transition in the peridotite of ~720 °C at a pressure of ~0.6–1.6 GPa. In the pressure range, low‐pressure side, which overlaps with conditions of surrounding crustal rocks, is more consistent with obtained fault structures and regional tectonics. This condition lies on a geotherm of an oceanic lithosphere of the age of ~10 Ma and is consistent with a predicted temperature and depth using published flow laws of olivine.
Carbon Dioxide Fluxes to the Atmosphere From Waters Within Flooded Forests in the Amazon Basin
Authors: Amaral Joao Henrique Fernandes , Melack John M. , Barbosa Pedro Maia , MacIntyre Sally , Kasper Daniele , Cortés Alicia , Silva Thiago Sanna Freire , Nunes de Sousa Rodrigo , Forsberg Bruce R. 
Published: January 2020

AbstractInundated tropical forests are underrepresented in analyses of the global carbon cycle and constitute 80% of the surface area of aquatic environments in the lowland Amazon basin. Diel variations in CO2 concentrations and exchanges with the atmosphere were investigated from August 2014 to September 2016 in two flooded forests sites with different wind exposure within the central Amazon floodplain (3°23′S, 60°18′W). CO2 profiles and estimates of air–water gas exchange were combined with ancillary environmental measurements. Surface CO2 concentrations ranged from 19 to 329 μM, CO2 fluxes ranged from −0.8 to 55 mmol m−2 hr−1 and gas transfer velocities ranged from 0.2 to 17 cm hr−1. CO2 concentrations and fluxes were highest during the high water period. CO2 fluxes were three times higher at a site with more wind exposure (WE) compared to one with less exposure (WP). Emissions were higher at the WP site during the day, whereas they were higher at night at the WE site due to vertical mixing. CO2 concentrations and fluxes were lower at the W P site following an extended period of exceptionally low water. The CO2 flux from the water in the flooded forest was about half of the net primary production of the forest estimated from the literature. Mean daily fluxes measured in our study (182 ± 247 mmol m−2d−1) are higher than or similar to the few other measurements in waters within tropical and subtropical flooded forests and highlight the importance of flooded forests in carbon budgets.
Basement Structures Have Crucial Influence on Rift Development: Insights From the Jianghan Basin, Central China
Authors: Wu Lulu , Mei Lianfu , Paton Douglas A. , Liu Yunsheng , Shen Chuanbo , Liu Zhaoqian , Luo Jin , Min Caizheng , Li Minghua , Wen Hui 
Published: January 2020

AbstractCrustal heterogeneity has a fundamental influence on rift development; however, the detailed architecture of structures within crystalline basement is commonly poorly understood, resulting in the exact manner in which basement structures control rift development being rather enigmatic. The Jianghan Basin evolved on a crystalline basement covered by thick prerift strata, providing an excellent opportunity to unravel the enigma. Using extensive 2‐D and 3‐D seismic, borehole and field data from the Jianghan Basin in combination, we investigate the deformation characteristics of basement structures and unravel their relationship with the overlying rift basin. A most striking feature of the basement structures in the Jianghan Basin is that prerift strata near the major rift‐related fault planes in the hanging walls are older than these in the footwalls and for most faults prerift strata in the hanging walls become increasingly older while approaching the fault planes, suggesting that these rift‐related faults have reactivated preexisting thrusts or thrusts associated with unroofed folds through negative structural inversion. All the major rift‐related faults have very high Dmax/L ratios (0.11–0.66) compared to typical normal faults, likely resulting from either constant length fault model or low frictional strength. By unraveling the prerift deformation intensity and structural division of basement structures in the Jianghan Basin, we propose that basement structures not only have crucial influence on rift geometry but also control rift localization. The reactivation of multidirectional basement structures and multidirectional extension with rift localization in the Jianghan Basin provides yet unrecognized insights into the development of tripartite rift systems.
Leaky-gut enhanced lupus progression in the Fc gamma receptor-IIb deficient and pristane-induced mouse models of lupus
Authors: Thim-uam Arthid , Surawut Saowapha , Issara-Amphorn Jiraphorn , Jaroonwitchawan Thiranut , Hiengrach Pratsanee , Chatthanathon Piraya , Wilantho Alisa , Somboonna Naraporn , Palaga Tanapat , Pisitkun Prapaporn , Leelahavanichkul Asada 
Published: January 2020

AbstractThe influence of gut-leakage or gut-microbiota upon lupus progression was explored in 2 lupus mouse models. Pristane, administered in 4-wk-old wild-type (WT) female mice, induced lupus characteristics at 24-wk-old similar to the lupus-onset in FcGRIIb−/− mice. Gut-microbiota alteration was induced by co-housing together with the gavage of feces from 40-wk-old FcGRIIb−/− mice (symptomatic lupus). On the other hand, gut-leakage was induced by dextran sulfate solution (DSS). DSS and gut-microbiota alteration induced high serum anti-dsDNA immunoglobulin (Ig) as early as 30 days post-DSS only in FcGRIIb−/− mice. DSS, but not gut-microbiota alteration, enhanced lupus characteristics (serum creatinine and proteinuria) in both lupus models (but not in WT) at 60 days post-DSS. Indeed, DSS induced the translocation of molecular components of gut-pathogens as determined by bacterial burdens in mesenteric lymph node (MLN), endotoxemia (gut-bacterial molecule) and serum (1→3)-β-D-glucan (BG) (gut-fungal molecule) as early as 15 days post-DSS together with enhanced MLN apoptosis in both WT and lupus mice. However, DSS induced spleen apoptosis in FcGRIIb−/− and WT mice at 30 and 60 days post-DSS, respectively, suggesting the higher impact of gut-leakage against spleen of lupus mice. In addition, macrophages preconditioning with LPS plus BG were susceptible to starvation-induced apoptosis, predominantly in FcGRIIb−/− cell, implying the influence of gut-leakage upon cell stress. In summary, gut-leakage induced gut-translocation of organismal-molecules then enhanced the susceptibility of stress-induced apoptosis, predominantly in lupus. Subsequently, the higher burdens of apoptosis in lupus mice increased anti-dsDNA Ig and worsen lupus severity through immune complex deposition. Hence, therapeutic strategies addressing gut-leakage in lupus are interesting.
Vegetation productivity summarized by the Dynamic Habitat Indices explains broad-scale patterns of moose abundance across Russia
Authors: Razenkova Elena , Radeloff Volker C. , Dubinin Maxim , Bragina Eugenia V. , Allen Andrew M. , Clayton Murray K. , Pidgeon Anna M. , Baskin Leonid M. , Coops Nicholas C. , Hobi Martina L. 
Published: January 2020

AbstractIdentifying the factors that determine habitat suitability and hence patterns of wildlife abundances over broad spatial scales is important for conservation. Ecosystem productivity is a key aspect of habitat suitability, especially for large mammals. Our goals were to a) explain patterns of moose (Alces alces) abundance across Russia based on remotely sensed measures of vegetation productivity using Dynamic Habitat Indices (DHIs), and b) examine if patterns of moose abundance and productivity differed before and after the collapse of the Soviet Union. We evaluated the utility of the DHIs using multiple regression models predicting moose abundance by administrative regions. Univariate models of the individual DHIs had lower predictive power than all three combined. The three DHIs together with environmental variables, explained 79% of variation in moose abundance. Interestingly, the predictive power of the models was highest for the 1980s, and decreased for the two subsequent decades. We speculate that the lower predictive power of our environmental variables in the later decades may be due to increasing human influence on moose densities. Overall, we were able to explain patterns in moose abundance in Russia well, which can inform wildlife managers on the long-term patterns of habitat use of the species.
Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system
Authors: Nogi Yasuko , Ahasan Md Monjurul , Murata Yoshihiro , Taniguchi Mutsuo , Sha Md Fazley Rabbi , Ijichi Chiori , Yamaguchi Masahiro 
Published: January 2020

AbstractVarious neural systems cooperate in feeding behaviour, and olfaction plays crucial roles in detecting and evaluating food objects. While odour-mediated feeding behaviour is highly adaptive and influenced by metabolic state, hedonic cues and learning processes, the underlying mechanism is not well understood. Feeding behaviour is regulated by orexigenic and anorexigenic neuromodulatory molecules. However, knowledge of their roles especially in higher olfactory areas is limited. Given the potentiation of feeding behaviour in hunger state, we systemically examined the expression of feeding-related neuromodulatory molecules in food-restricted mice through quantitative PCR, in the olfactory bulb (OB), olfactory tubercle (OT), and remaining olfactory cortical area (OC). The OT was further divided into attraction-related anteromedial, aversion-related lateral and remaining central regions. Examination of 23 molecules including neuropeptides, opioids, cannabinoids, and their receptors as well as signalling molecules showed that they had different expression patterns, with many showing elevated expression in the OT, especially in the anteromedial and central OT. Further, in mice trained with odour-food association, the expression was significantly altered and the increase or decrease of a given molecule varied among areas. These results suggest that different olfactory areas are regulated separately by feeding-related molecules, which contributes to the adaptive regulation of feeding behaviour.
Hyperreflective Foci in the Outer Retinal Layers as a Predictor of the Functional Efficacy of Ranibizumab for Diabetic Macular Edema
Authors: Yoshitake Tatsuya , Murakami Tomoaki , Suzuma Kiyoshi , Dodo Yoko , Fujimoto Masahiro , Tsujikawa Akitaka 
Published: January 2020

AbstractAnti-VEGF drugs are as the first-line therapies for diabetic macular edema (DME). In this study, we investigated the association between hyperreflective foci in the outer retinal layers and functional efficacy in DME patients who received intravitreal ranibizumab (IVR) injections. We retrospectively reviewed 77 eyes of 71 patients with DME treated with pro re nata IVR injections for at least 12 months. We evaluated how baseline hyperreflective foci in the outer retinal layers on spectral domain optical coherence tomography images were associated with an improvement in logarithm of the minimum angle of resolution visual acuity (logMAR VA) at 12 months. Forty-three eyes with hyperreflective foci in the outer retinal layers had greater VA improvement than 34 eyes without such foci at 12 months. Multivariate analyses demonstrated that both logMAR VA and hyperreflective foci in the outer retinal layers at baseline were associated with VA improvement. Structural analyses revealed that the central subfield thickness was decreased and that the ellipsoid zone of photoreceptors was improved more significantly in eyes with hyperreflective foci in the outer layers than eyes without such lesions. Baseline hyperreflective foci in the outer retinal layers predict the functional efficacy of IVR injections for DME.
Platelet transfusion in patients with aneurysmal subarachnoid hemorrhage is associated with poor clinical outcome
Authors: Post R. , Tjerkstra M. A. , Middeldorp S. , Van den Berg R. , Roos Y. B. W. E. M. , Coert B. A. , Verbaan D. , Vandertop W. P. 
Published: January 2020

AbstractPatients with subarachnoid hemorrhage (SAH) who are using antiplatelet drugs prior to their hemorrhage, often receive platelet transfusions to reverse antiplatelet effects prior to life-saving surgical interventions. However, little is known about the effect of platelet transfusion on patient outcome in these patients. The aim of this study is to investigate the effect of platelet transfusion on clinical outcome in patients with aneurysmal SAH (aSAH) who use antiplatelet agents. Consecutive adult patients with an aSAH admitted between 2011 and 2015 to the Academic Medical Center (Amsterdam, the Netherlands) were included. Demographic characteristics and in-hospital complications were compared and clinical outcome was assessed after six months. Multivariable logistic regression analysis was performed to correct for confounding variables. A total of 364 patients with an aSAH were included. Thirty-eight (10%) patients underwent platelet transfusion during admission. Patients receiving platelet transfusion had worse clinical outcome (modified Rankin Scale score 4–6) at six months compared to patients without platelet transfusion (65% versus 32%, odds ratio 4.0, 95% confidence interval:1.9–8.1). Multivariable logistic regression analysis showed that platelet transfusion during admission was associated with unfavorable clinical outcome after six months; adjusted for age, treatment modality, modified Fisher and WFNS on admission (adjusted odds ratio 3.3, 95% confidence interval: 1.3–8.4). In this observational study, platelet transfusion was associated with poor clinical outcome at six months after correcting for confounding influences. In aSAH patients who need surgical treatment at low risk of bleeding, the indication for platelet transfusion needs careful weighing of the risk-benefit-balance.
Cation permeability in CorA family of proteins
Authors: Stetsenko Artem , Guskov Albert 
Published: January 2020

AbstractCorA proteins belong to 2-TM-GxN family of membrane proteins, and play a major role in Mg2+ transport in prokaryotes and eukaryotic mitochondria. The selection of substrate is believed to occur via the signature motif GxN, however there is no consensus how strict this selection within the family. To answer this question, we employed fluorescence-based transport assays on three different family members, namely CorA from bacterium Thermotoga maritima, CorA from the archeon Methanocaldococcus jannaschii and ZntB from bacterium Escherichia coli, reconstituted into proteoliposomes. Our results show that all three proteins readily transport Mg2+, Co2+, Ni2+ and Zn2+, but not Al3+. Despite the similarity in cation specificity, ZntB differs from the CorA proteins, as in the former transport is stimulated by a proton gradient, but in the latter by the membrane potential, confirming the hypothesis that CorA and ZntB proteins diverged to different transport mechanisms within the same protein scaffold.
The rapid increases in microplastics in urban lake sediments
Authors: Dong Mingtan , Luo Zejiao , Jiang Qingfeng , Xing Xinli , Zhang Qiaoqiao , Sun Yue 
Published: January 2020

AbstractMicroplastics have received widespread attention as an emerging global pollutant. However, the research on the abundance and characteristics of microplastics entering the environment throughout history has been limited. Meanwhile, the determination of the start of the Anthropocene is important because humans have become a vital force affecting the environment and Earth surface processes. It is unclear whether the plastic can be used as an artefact to indicate the start of the Anthropocene. In this study, combined with 137Cs, 210Pb, and spherical carbonaceous particles (SCP) high-resolution chronology, a microplastics-time curve was established by using the sedimentary record from an urban lake in Wuhan city. The microplastic abundance increased from 741 items·kg−1 to 7707 items·kg−1 over the past 60 years. The microplastics were mainly fibres and composed of polyester and rayon polymers, which indicated that the microplastics most likely originated from textiles. The surfaces of the older microplastics were rough and weathered with many absorbed elements. Microplastics are similar to fossils belonging to the Anthropocene, and may be used as an indicator. The comparison of microplastic-time curves in different records on a global scale will be necessary in the future.
Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits
Authors: Wu Zhenyu , Zhu Yanli , Liu Hongli , Liu Gongyan , Li Fuchang 
Published: January 2020

Abstract
Wnt signaling plays an important role in the growth and development of hair follicles (HFs). Among the signaling molecules, Wnt10b was shown to promote the differentiation of primary skin epithelial cells toward the hair shaft and inner root sheath of the HF cells in mice in vitro. Whisker HFs were isolated from Rex rabbits and cultured in vitro to measure hair shaft growth. Meanwhile, dermal papilla cells (DPCs) were isolated and cultured in vitro. Treatment with AdWnt10b or the Wnt/β-Catenin Pathway inhibitor, XAV939, assessed the DPCs proliferation by CCK-8 assay. And the cell cycle was also analyzed by flow cytometry. We found that Wnt10b could promote elongation of the hair shaft, whereas XAV-939 treatment could eliminated this phenomenon. AdWnt10b treatment promoted the proliferation and induced G1/S transition of DPCs. AdWnt10b stimulation up-regulated β-Catenin protein in DPCs. Inhibition of Wnt/β-Catenin signaling by XAV-939 could decreased the basal and Wnt10b-enhanced proliferation of DPCs. And could also suppress the cell cycle progression in DPCs. In summary, our study demonstrates that Wnt10b could promote HFs growth and proliferation of DPCs via the Wnt/β-Catenin signaling pathway in Rex rabbits.
Hydrolysis of three different head groups phospholipids by chicken group V phospholipase A2 using the monomolecular film technique
Authors: Karray Aida , Ali Madiha Bou , Raida Jallouli , Sofiane Bezzine 
Published: January 2020

Abstract
The kinetic aspects of lipolysis by pulmonary phospholipase A2 (ChPLA2-V), chicken intestinal phospholipase A2 (ChPLA2-IIA) and chicken pancreatic phospholipase A2 (ChPLA2-IB), from chicken have been compared using the monomolecular films technique, on short-chain phospholipids (with three different head groups) and on long-chain phospholipids.
The main conclusions from our experimental data indicate that the maximum catalytic activities of ChPLA2-V on 1,2 phosphatidylcholine and 1,2 phosphatidylethanolamine reached 15.26 and 36.12 moles/cm2.min.mM, respectively, at a pressure of 15 and 35 dynes/cm, respectively. Whereas, those of ChPLA2-IB were 3.58 (at the pressure of 20 dynes/cm) and 4.9 moles/cm2.min.mM. However, hydrolysis of phosphatidylglycerol monolayers (C12PG), were very much higher compared with all the substrates tested with 122 moles/cm2.min. Surprisingly, the hydrolysis rate of ChPLA2-V on long-chain phosphatidylglycerol (C18PG) was very low (1.45 moles/cm2.min) compared with all tested substrates, even with the use of p-cyclodextrin. And thus, the fatty acid preference of ChPLA2-V was 2-decanoyl &gt; 2-oleoyl with a PG head group.
In order to gain significant correlations between enzyme’s structures and their relative functions, we tried to examine the surface electrostatic potentials of the various secreted phospholipase 2 (sPLA2) from chicken. In the present study, we detailed that the substrate affinity, specificity and the hydrolysis rates of sPLA2 at each interface is governed by the surface electrostatic potentials and hydrophobic interactions operative at this surface.