bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of perceived neighborhood environment and physical activity with metabolic syndrome among Mexican–Americans adults: a cross sectional examination
Authors: Joseph Rodney P. , Vega-López Sonia 
Published: June 2020

Abstract
Objective
This secondary data analysis examined associations among perceived neighborhood environmental factors, physical activity (PA), and the presence of metabolic syndrome (MS) in Mexican–American (MA) adults. Seventy-five MA adults (mean age of 37.9 ± 9.3 years) provided anthropometric, biomarker, and survey data. The Neighborhood Scales Questionnaire evaluated six perceived neighborhood factors: walking environment, aesthetic quality, safety, violence, social cohesion, and activities with neighbors. The Rapid Assessment of PA questionnaire assessed PA. MS was determined according to ATP III criteria.

Results
PA was significantly associated with MS (OR = .338, CI .204–.738). Neighborhood factors of safety (B = .255, p = .024), walking environment (B = .384, p = .001), and social cohesion (B = .230, p = .043) were positively associated with PA. No other neighborhood factors were significantly related to PA. Analyses examining whether neighborhood factors moderated the relationship between PA and MS were not significant.
Current antimicrobial use in farm animals in the Republic of Ireland
Authors: Martin Hannah , Manzanilla Edgar Garcia , More Simon J. , O’Neill Lorcan , Bradford Lisa , Carty Catherine I. , Collins Áine B. , McAloon Conor G. 
Published: June 2020

AbstractAntimicrobial resistance has been recognised as one of the most difficult challenges facing human and animal health in recent decades. The surveillance of antimicrobial use in animal health plays a major role in dealing with the growing issue of resistance. This paper reviews current data available on antimicrobial use in farmed animals in the Republic of Ireland, including each of the major livestock production sectors; pigs, poultry, dairy, beef and sheep. A systematic literature search was conducted to identify relevant published literature, and ongoing research was identified through the network of authors and searches of each of the research databases of the main agriculture funding bodies in Ireland. The varying quantities and quality of data available across each livestock sector underlines the need for harmonisation of data collection methods. This review highlights the progress that has been made regarding data collection in the intensive production sectors such as pigs and poultry, however, it is clear there are significant knowledge gaps in less intensive industries such as dairy, beef and sheep. To comply with European regulations an antimicrobial data collection system is due to be developed for all food-producing animals in the future, however in the short-term surveillance studies have allowed us to build a picture of current use within the Republic of Ireland. Further studies will allow us to fill current knowledge gaps and build a more comprehensive overview of antimicrobial use in farm animals in Ireland.
A result on the limiting spectral distribution of random matrices with unequal variance entries
Authors: Jin Shaojia , Xie Junshan 
Published: June 2020

AbstractA classical result in random matrix theory reveals that the limiting spectral distribution of a Wigner matrix whose entries have a common variance and satisfy other regular assumptions almost surely converges to the semicircular law. In the paper, we will relax the assumption of uniform covariance of each entry, when the average of the normalized sums of the variances in each row of the data matrix converges to a constant, we prove that the same limiting spectral distribution holds. A similar result on a sample covariance matrix is also established. The proofs mainly depend on the Stein equation and the generalized Stein equation of independent random variables.
A close look at the biology of SARS-CoV-2, and the potential influence of weather conditions and seasons on COVID-19 case spread
Authors: Adedokun Kamoru A. , Olarinmoye Ayodeji O. , Mustapha Jelili O. , Kamorudeen Ramat T. 
Published: June 2020

Abstract
Background
There is sufficient epidemiological and biological evidence of increased human susceptibility to viral pathogens such as Middle East respiratory syndrome coronavirus, respiratory syncytial virus, human metapneumovirus and influenza virus, in cold weather. The pattern of outbreak of the coronavirus disease 2019 (COVID-19) in China during the flu season is further proof that meteorological conditions may potentially influence the susceptibility of human populations to coronaviruses, a situation that may become increasingly evident as the current global pandemic of COVID-19 unfolds.

Main body
A very rapid spread and high mortality rates have characterized the COVID-19 pandemic in countries north of the equator where air temperatures have been seasonally low. It is unclear if the currently high rates of COVID-19 infections in countries of the northern hemisphere will wane during the summer months, or if fewer people overall will become infected with COVID-19 in countries south of the equator where warmer weather conditions prevail through most of the year. However, apart from the influence of seasons, evidence based on the structural biology and biochemical properties of many enveloped viruses similar to the novel severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 (aetiology of COVID-19), support the higher likelihood of the latter of the two outcomes. Other factors that may potentially impact the rate of virus spread include the effectiveness of infection control practices, individual and herd immunity, and emergency preparedness levels of countries.

Conclusion
This report highlights the potential influence of weather conditions, seasons and non-climatological factors on the geographical spread of cases of COVID-19 across the globe.
Does endoscopic sinus surgery alter the biomechanics of the orbit?
Authors: Sowerby Leigh J , Harris Matthew S. , Joshi Rootu , Johnson Marjorie , Jenkyn Tom , Moore Corey C. 
Published: June 2020

Objective The purpose of this study is to determine if removal of ethmoid cell septations as commonly performed in endoscopic sinus surgery leads to a change in orbital wall fracture patterns and the force required to create them. Methods Six fresh-frozen cadaveric heads were acquired and underwent endoscopic uncinectomy, maxillary antrostomy, and anterior and posterior ethmoidectomy on one, randomized, side. The contralateral sinuses were used as intra-specimen control. Hyaluronic acid gel globe injections were performed to simulate normal intra-ocular pressure. Post-op CT scans confirmed no orbital fractures or violation of the lamina papyracea prior to trauma testing. Orbital trauma was induced using a guided weight-drop technique. Both orbits were tested in random order, and sequentially higher drops were performed until both the test and control side demonstrated an orbital fracture on CT scan. Results In all six heads, the post-sinus surgery side incurred a medial orbital wall fracture, and no orbital floor fractures were identified. On the other hand, on the control side, all six heads incurred orbital floor fractures at drop heights equal to, or higher than, the surgical side. Fisher's exact test demonstrated a significant difference in fracture pattern ( p <  0.001). Conclusions To our knowledge, this is the first demonstration that the structures removed during sinus surgery may act as a buttress for the medial orbital wall. The anatomic changes of sinus surgery may alter the biomechanics of the orbit and affect the pattern of subsequent traumatic blowout fractures.
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Authors: Saul J. , Hutchins E. , Reiman R. , Saul M. , Ostrow L. W. , Harris B. T. , Van Keuren-Jensen K. , Bowser R. , Bakkar N. 
Published: June 2020

AbstractThe choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood from the cerebrospinal fluid (CSF). In addition to its role as a physical barrier, the CP functions in CSF secretion, transport of nutrients into the central nervous system (CNS) and a gated point of entry of circulating immune cells into the CNS. Aging and neurodegeneration have been reported to affect CP morphology and function and increase protein leakage from blood to the CSF. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with both upper and lower motor neuron loss, as well as altered proteomic and metabolomic signatures in the CSF. The role of the BCSFB and the CP in ALS is unknown. Here we describe a transcriptomic and ultrastructural analysis of BCSFB and CP alterations in human postmortem tissues from ALS and non-neurologic disease controls. ALS-CP exhibited widespread disruptions in tight junctional components of the CP epithelial layer and vascular integrity. In addition, we detected loss of pericytes around ALS blood vessels, accompanied by activation of platelet aggregation markers vWF and Fibrinogen, reminiscent of vascular injury. To investigate the immune component of ALS-CP, we conducted a comprehensive analysis of cytokines and chemokine panels in CP lysates and found a significant down-regulation of M-CSF and V-CAM1 in ALS, as well as up-regulation of VEGF-A protein. This phenotype was accompanied by an infiltration of MERTK positive macrophages into the parenchyma of the ALS-CP when compared to controls. Taken together, we demonstrate widespread structural and functional disruptions of the BCSFB in human ALS increasing our understanding of the disease pathology and identifying potential new targets for ALS therapeutic development.
Stress and recovery perception, creatine kinase levels, and performance parameters of male volleyball athletes in a preseason for a championship
Authors: Berriel Guilherme Pereira , Costa Rochelle Rocha , da Silva Edson Soares , Schons Pedro , de Vargas Guilherme Droescher , Peyré-Tartaruga Leonardo Alexandre , Kruel Luiz Fernando Martins 
Published: June 2020

Abstract
Background
Training load and adequate recovery have been identified as essential elements to improve well-being and performance in team sports and avoid non-functional overreaching and overtraining.

Objective
This cohort study sought to analyze the stress and recovery perceptions, creatine kinase levels (CK), and vertical jump performance of volleyball athletes at different training times during a championship preseason.

Methods
Thirteen high-level male volleyball players (23.80 ± 5.40 years, 91.50 ± 8.80 kg, and 193.10 ± 6.40 cm) completed the RESTQ-Sport questionnaire on stress and recovery perception, and blood samples were collected to evaluate CK levels. These measures were performed six times over 16 weeks, while jumps such as squat jump (SJ), countermovement jump (CMJ), and countermovement jump arm (CMJA) were performed at three of those times for specific performance evaluation.

Results
The stress perception and recovery perception indices increased and decreased, respectively, in the pre-competitive phase, while CK levels presented an initial rise, maintenance over the training period, and a drop. Vertical jump heights increased significantly throughout the preparatory period regardless of the type of jump. In all training phases, CMJA values exceeded CMJ and SJ values, and CMJ values exceeded SJ values.

Conclusions
Positive adaptations were elicited by training stimuli, resulting in improvements in performance. Conversely, load training variables indicated higher levels of stress and muscle damage, together with lower perceptions of recovery during the championship preseason.
Multi-parametric magnetic resonance imaging in acute necrotizing encephalopathy of children: validity and prognostic value
Authors: Ibrahim Rania S. M. , Elzayat W. , Seif H. M. , El-Kiki H. A. , Emad-Eldin S. , Shahin M. , Kamel S. M. , Osama R. , Zakaryia R. , Fatouh M. , Hachem Rania H. 
Published: June 2020

Abstract
Background
Acute necrotizing encephalopathy of children (ANEC) is a rare fulminant type of acute encephalopathy that mainly occurs in children with a characteristic clinico-radiological pattern. It is commonly preceded by viral infections. The condition carries a poor prognosis with high morbidity and mortality rates. We highlight the relationship between diagnostic multi-parametric magnetic resonance imaging (MRI) findings and correlate them with the clinical outcome of children with ANEC by enrollment of MRI scoring.

Results
The thalami were involved in all 30 patients, brain stem in 80%, basal ganglia (13.3%), cerebral white matter (WM) in 73%, and cerebellar WM in 33%. Hemorrhage was present in 86.7% patients, edema 80%, and necrosis in 13.3%. We found that the patients having the highest MRI scores were in the poor outcome category; whereas the patients with lower MR score (1 or 2) had better outcomes. Statistically positive correlation (r= 0.1198) was found between the multi-parametric MR score and the outcome category.

Conclusion
An extended multi-parametric MRI should be performed in ANEC, allowing early detection and scoring of the disease for better prognosis. There is a positive correlation between the clinical outcome and the MR scoring.
Light-controlled calcium signalling in prostate cancer and benign prostatic hyperplasia
Authors: Sharma Vipin , Rana Rita , Baksi Ruma , Borse Swapnil P. , Nivsarkar Manish 
Published: June 2020

Abstract
Background
Identifying ways to reduce the burden of prostate cancer (Pca) or benign prostatic hyperplasia (BPH) is a top research priority. It is a typical entanglement seen in men which is portrayed by trouble in micturition. It stands as a significant problem in our society. Different molecular biomarker has high potential to treat Pca or BPH but also causes serious side effects during treatment.

Main text
The role of calcium signalling in the alteration of different biomarkers of Pca or BPH is important. Therefore, the photoswitch drugs may hold the potential to rebalance the altered calcium signaling cascade and the biomarker levels. Thereby play a significant role in the management of Pca and BPH. Online literature searches such as PubMed, Web of Science, Scopus, and Google Scholar were carried out. The search terms used for this review were photo-pharmacology, photo-switch drug, photodynamic therapy, calcium signalling, etc. Present treatment of Pca or BPH shows absence of selectivity and explicitness which may additionally result in side effects. The new condition of the calcium flagging may offer promising outcomes in restoring the present issues related with prostate malignancy and BPH treatment.

Conclusion
The light-switching calcium channel blockers aim to solve this issue by incorporating photo-switchable calcium channel blockers that may control the signalling pathway related to proliferation and metastasis in prostate cancer without any side effects.

Graphical abstract
Schematic diagram explaining the proposed role of photo-switch therapy in curbing the side effects of active drugs in Pca (prostate cancer) and BPH (benign prostatic hyperplasia). a) Delivery of medication by ordinary strategies and irreversible phototherapy causes side effects during treatment. Utilization of photo-switch drug to control the dynamic and inert condition of the medication can cause the medication impacts as we required in prostate cancer and BPH. b) Support of harmony between the calcium signaling is essential to guarantee ordinary physiology. Increment or abatement in the dimensions of calcium signaling can result in changed physiology. c) Major factors involved in the pathogenesis of BPH; downregulation of vitamin D receptor (VDR) and histone deacetylase (HDAC) can prevent BPH. Similarly, downregulation of α-1 adrenoceptor can reduce muscle contraction, while overexpression of β-3 adrenoceptor in BPH can promote further muscle relaxation in BPH treatment therapy. Inhibition of overexpressed biomarkers in BPH TRPM2-1: transient receptor potential cation channel subfamily M member 1; TRPM2-2: transient receptor potential cation channel subfamily M member 2; Androgens; CXCL5: C-X-C motif chemokine ligand 5; TGFβ-1: transforming growth factor β-1; TXA2; thromboxane-2; NMDA: N-methyl-d-aspartate can be the potential target in BPH therapy.
Impact of Food and Drink Administration Vehicles on Paediatric Formulation Performance: Part 1—Effects on Solubility of Poorly Soluble Drugs
Authors: Martir J. , Flanagan T. , Mann J. , Fotaki N. 
Published: June 2020

AbstractFood and drinks are commonly used to facilitate administration of paediatric medicines to improve palatability and enhance patient compliance. However, the impact of this practice on drug solubility and on oral drug bioavailability is not usually studied. Based on recommended strategies for oral administration of paediatric medicines with food and drink vehicles, the aims of this study were (i) to measure the physicochemical properties of (soft) food and drink vehicles, commonly mixed with paediatric medicines prior to administration, and (ii) to assess the impact of the co-administered vehicles on the solubility of two poorly soluble paediatric drugs. Montelukast (sodium) and mesalazine were selected as the model compounds. Distinct differences were observed between the physicochemical properties (i.e. pH, surface tension, osmolality, viscosity and buffer capacity) and macronutrient composition (i.e. fat, sugar and protein content) of the different soft foods and drinks, not only among vehicle type but also within vehicles of the same subtype. Solubility studies of the two model compounds in selected drinks and soft foods resulted in considerably different drug solubility values in each vehicle. The solubility of the drugs was significantly affected by the vehicle physicochemical properties and macronutrient composition, with the solubility of montelukast being driven by the pH, fat and protein content of the vehicles and the solubility of mesalazine by vehicle osmolality, viscosity and sugar content. This vehicle-dependent impact on drug solubility could compromise its bioavailability, and ultimately affect the safety and/or efficacy of the drug and should be taken into consideration during paediatric product development.
A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization
Authors: Sankaran Divya Ganapathi , Stemm-Wolf Alexander J. , McCurdy Bailey L. , Hariharan Bharath , Pearson Chad G. 
Published: June 2020

ABSTRACT
Microtubules (MTs) promote important cellular functions including migration, intracellular trafficking, and chromosome segregation. The centrosome, comprised of two centrioles surrounded by the pericentriolar material (PCM), is the cell's central MT-organizing center. Centrosomes in cancer cells are commonly numerically amplified. However, the question of how the amplification of centrosomes alters MT organization capacity is not well studied. We developed a quantitative image-processing and machine learning-aided approach for the semi-automated analysis of MT organization. We designed a convolutional neural network-based approach for detecting centrosomes, and an automated pipeline for analyzing MT organization around centrosomes, encapsulated in a semi-automatic graphical tool. Using this tool, we find that breast cancer cells with supernumerary centrosomes not only have more PCM protein per centrosome, which gradually increases with increasing centriole numbers, but also exhibit expansion in PCM size. Furthermore, cells with amplified centrosomes have more growing MT ends, higher MT density and altered spatial distribution of MTs around amplified centrosomes. Thus, the semi-automated approach developed here enables rapid and quantitative analyses revealing important facets of centrosomal aberrations.
Oxygen consumption of drift-feeding rainbow trout: the energetic tradeoff between locomotion and feeding in flow
Authors: Johansen Jacob L. , Akanyeti Otar , Liao James C. 
Published: June 2020

ABSTRACT
To forage in fast, turbulent flow environments where prey is abundant, fishes must deal with the high associated costs of locomotion. Prevailing theory suggests that many species exploit hydrodynamic refuges to minimize the cost of locomotion while foraging. Here, we challenge this theory based on direct oxygen consumption measurements of drift-feeding trout (Oncorhynchus mykiss) foraging in the freestream and from behind a flow refuge at velocities up to 100 cm s−1. We demonstrate that refuging is not energetically beneficial when foraging in fast flows because of a high attack cost and low prey capture success associated with leaving a station-holding refuge to intercept prey. By integrating optimum foraging theory with empirical data from respirometry and video tracking, we developed a mathematical model to predict when drift-feeding fishes should exploit or avoid refuges based on prey density, size and flow velocity. Our optimum foraging and refuging model provides new mechanistic insights into locomotor costs, habitat use and prey choice of fish foraging in current-swept habitats.
City of Black Gold: Oil, Ethnicity, and the Making of Modern Kirkuk, Arbella Bet-Shlimon (2019)
Authors: Cole Camille Lyans 
Published: June 2020

Review of: City of Black Gold: Oil, Ethnicity, and the Making of Modern Kirkuk, Arbella Bet-Shlimon (2019)
Stanford: Stanford University Press, 296 pp.,
ISBN 978-1-50360-812-2, h/bk, $85
ISBN 978-1-50360-913-6, p/bk, $14.25
ISBN 978-1-50360-914-3, e/bk, $26.56
Thrash metal, del sonido al contenido: Origen y gestación de una contracultura chilena (‘Thrash metal, from sound to content: Origin and development of a Chilean counterculture’), Maximiliano Sánchez Mondaca (2014)
Authors: Keough Christian 
Published: June 2020

Review of: Thrash metal, del sonido al contenido: Origen y gestación de una contracultura chilena (‘Thrash metal, from sound to content. Origin and development of a Chilean counterculture’), Maximiliano Sánchez Mondaca (2014)
Santiago: RIL Editores, 170 pp.,
ISBN 978-9-56010-059-7, p/bk, $9.99
good Samaritan has Arrived
Authors: Venthan Ananthavinayagan Thamil 
Published: June 2020

The purpose of this article is to investigate the ongoing attempts by the West to colonize the Non-Western cultures by the means of religion. To this end, the missionary was and is without doubt the frontrunner for the standard of civilization, providing the pretext and fertile ground for the subsequent infiltration of the colonialist who was eager to carve an empire in the ‘discovered’ world - with the goal to exploit African resources for his own good. The exploitation of the resources in the colonized world was accompanied by the early religious Missionaries who set up secular missionaries. Their travels to other countries was not the bible but other documents of conquest such as dubious treaties, guns and trinkets to attract the unsuspecting colonized to be lured to them. Missionaries often aligned themselves with the powerful in order to achieve their prime objective of “saving souls” more rapidly. Colonization, civilisation and religion are means to the creation of imperialism. This article, to this end, will inquire the role of the non-Western world to resist attempts of there West to engage in practices of repeated colonization under the pretext of religion.