bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a clinical pharmacist in ultrasound-guided venous thromboembolism screening in hospitalized COVID-19 patients: a pilot prospective study.
Authors: Gillespie Laura , Khan Rashid Z. , Stillson John E. , Bunch Connor M. , Shariff Faisal Salim , Speybroeck Jacob , Grisoli Anne , Schmidt Meredith Wireman , Phyu Htay , Jablonski Jason , Wells Byars , Fulkerson Dan H. , Oancea Lyndsay , Leiser Abraham , Walsh Mark 
Published: November 2020

Abstract
Background: The recognition, prevention and treatment of venous thromboembolism (VTE) remains a major challenge in the face of the recent SARS-COV-2 pandemic which has been associated with significant cardiovascular, renal, respiratory and hematologic complications related to hypercoagulability. There has been little literature thus far on the utility of screening ultrasound and role of the clinical pharmacist in treating these patients.Methods: We present a prospective pilot program of thirty-one consecutive SARS-CoV-2 patients who were provided four extremity screening ultrasounds for VTE on admission. This was coordinated by a clinical pharmacist as part of a multidisciplinary approach. Quantitative and qualitative data were recorded with the goal of describing the utility of the clinical pharmacist in ultrasound screening. Data collected include: demographics, information on clinical symptoms or signs at presentation, and laboratory and radiologic results during the hospitalization from each individual electronic medical record.Results: Nine of the thirty-one patients presented with venous thrombosis. Of the nine patients, there were twenty-two total clotted vessels, all of which were asymptomatic. The clinical pharmacist, as the coordinator for a multidisciplinary COVID-19 associated coagulopathy management team, drafted a screening and treatment protocol for anticoagulation prophylaxis and therapy of VTE after ultrasound findings.Conclusion: VTE screening of hospitalized SARS-CoV-2 patients reveals a significant number of asymptomatic VTEs and justifies diagnostic, prophylactic, and treatment measures coordinated by a clinical pharmacist.
Decline in influenza cases in Mexico after the implementation of public health measures for COVID-19
Authors: Daniel Arellanos-Soto , Gerardo Padilla-Rivas , Javier Ramos-Jimenez , Kame Galan-Huerta , Sonia Lozano-Sepulveda , Natalia Martinez-Acuña , Consuelo Treviño-Garza , Manuel De la O-Cavazos , Roberto Montes de Oca-Luna , Maria Rivas-Estilla Ana 
Published: November 2020

Abstract
Mexico took swift action and has strictly followed mitigation measures to prevent the spread of coronavirus disease, COVID-19. The present study compared indicators of influenza activity in 2020 before and after public health measures were taken to reduce COVID-19 with the corresponding indicators from three preceding years and the immediate one, and the potential decrease in seasonal influenza cases. Nationwide surveillance data revealed a drastic decline in influenza diagnosis in outpatient clinics and public hospitals, positivity rates of clinical specimens, and confirmed severe cases during the following 10 weeks of 2020 as lockdown activities and control measures were established compared with the same period of 2019, suggesting that the measures taken for COVID-19 were effective in reducing the spread of other viral respiratory diseases in our country.
Clinical observation and analysis of patients with idiopathic membranous nephropathy combined with low 25(OH)D3 levels
Authors: Zou Fan , Huang Yu , Feng Lu-Huai , Yang Zhenhua 
Published: November 2020

Abstract
Background: To investigate correlations between 25-hydroxyvitamin D 3 [25(OH)D 3 ] levels and selected clinical indicators and renal pathology at initial onset of idiopathic membranous nephropathy (IMN) and to analyse changes in the main quantifiable indicators in IMN patients with different 25(OH)D 3 levels. Methods: A total of 109 patients admitted to the Department of Nephrology of the First Affiliated Hospital of Guangxi Medical University between August 2015 and April 2019 and diagnosed with IMN were reviewed. Comparative analysis of the effects of different 25(OH)D 3 levels on clinical and pathological indicators of IMN was performed, and changes in serum albumin, the estimated glomerular filtration rate (eGFR), serum creatinine and other clinical indicators in these patients during the follow-up were analysed. Results: The 109 patients with IMN had 25(OH)D 3 deficiency [25(OH)D 3 <70 nmol/L]. The incidence of nephrotic syndrome, serum phosphorus levels, high-sensitivity C-reactive protein (hs-CRP) levels, and erythrocyte sedimentation rates (ESRs) were higher in the 25(OH)D 3 <25 nmol/L group than in the 25(OH)D 3 ≥25 nmol/L group. In contrast, total protein (TP), albumin (ALB), serum calcium, and IgG levels were lower in the 25(OH)D 3 <25 nmol/L group (P<0.05). No pathological parameters differed significantly between the two groups (P>0.05). Bivariate correlation analysis showed that 25(OH)D 3 was positively correlated with nephrotic syndrome, TP levels, ALB levels, the eGFR, serum calcium levels and IgG levels (P<0.05) and negatively correlated with age, blood pressure, Scr levels, 24-hour urinary protein (UP) quantitation, serum phosphorus levels, hs-CRP levels and the ESR (P<0.05). In single-factor repeated measures analysis of variance, the ALB levels in the 25(OH)D 3 <25 nmol/L and 25(OH)D 3 ≥25 nmol/L groups showed an increasing trend but were lower in the 25(OH)D 3 <25 nmol/L group than in the 25(OH)D 3 ≥25 nmol/L group at each follow-up time point (P<0.001). Conclusion: Reduced 25(OH)D 3 levels are prevalent among IMN patients. During the follow-up, serum albumin increased significantly in patients receiving vitamin D supplementation. 25(OH)D 3 may play an important role in IMN development.
Sociopragmatics Analysis of Politeness Strategy of the Main Character's Dialogues of Tinker Bell in Secret of the Wings Movie
Authors: Mujiono Mujiono , Ula Avil Lailatul 
Published: November 2020

This study investigated the types and functions of politeness strategy used by the main character of Tinker Bell in Secret of the Wings movie. The study was a descriptive qualitative approach. The instrument of this study was document analysis. It focused on analyzing and interpreting recorded documents. To analyze the data, four interactional procedures were applied. Triangulation was used to justify the trustworthiness of data. The findings showed that the interaction between the main character and her addressee realized all politeness strategies. There were 39 data found in the conversation. Each politeness strategy's frequency was positive politeness in the first grade, with 51.3%, followed by a bald-on record with 33.3%. Negative politeness and 'off record' were the same positions with 7.7 %, %. Second, the researchers reported two politeness strategy functions indicated by the transactional view with 74.4 % and interactional view with 25.6%. Last, the main character applied the politeness strategy to have a close relationship, know each other, and avoid the addressee's imposition. This politeness strategy had implications on using politeness strategies of a language in communication aspects for the community.
Characterization of Phosphorylated Proteins Using Mass Spectrometry
Authors: Yu Li-Rong , Veenstra Timothy D. 
Published: November 2020

:
Phosphorylation is arguably the most important post-translational modification that occurs
within proteins. Phosphorylation is used as a signal to control numerous physiological activities
ranging from gene expression to metabolism. Identifying phosphorylation sites within proteins
was historically a challenge as it required either radioisotope labeling or the use of phospho-specific
antibodies. The advent of mass spectrometry (MS) has had a major impact on the ability to qualitatively
and quantitatively characterize phosphorylated proteins. In this article, we describe MS
methods for characterizing phosphorylation sites within individual proteins as well as entire proteome
samples. The utility of these methods is illustrated in examples that show the information
that can be gained using these MS techniques.
The Role of Targeted HIV Screening in the Emergency Department: A Scoping Review
Authors: Spagnolello Ornella , Gallagher Bernadette , Lone Nazir , Ceccarelli Giancarlo , D’Ettorre Gabriella , Reed Matthew J. 
Published: November 2020

Background:
Human immunodeficiency virus (HIV) infection continues to expand
worldwide, and a significant proportion of infection is still undiagnosed. Recent studies have addressed
the impact and feasibility of ‘opt-out’ HIV screening in Emergency Departments (EDs) in
urban settings at high HIV prevalence, whereas little is known about the yield of implementing ‘targeted’
HIV testing, especially in low-prevalence areas.

Objective:
The present study undertakes a scoping review of research carried out on the implementation
of targeted HIV screening of adult in EDs to determine the impact, feasibility and acceptability
of HIV testing in different HIV prevalence settings.

Design:
Online databases (EMBASE, MEDLINE) were used to identify papers published between
2000 to 2020. A three-concept search was employed with HIV (HIV, Human immunodeficiency
virus infection, HIV infections), targeted testing (Target, screening or testing) and emergency
medicine (Emergency Service, emergency ward, A&E, accident and emergency or Emergency Department)
(28th February 2020). Only full-text articles written in English, French, Spanish or Italian
and using impact and/or feasibility and/or acceptability of the program as primary or secondary outcomes
were analysed.

Results:
The search provided 416 articles. Of these, 12 met inclusion criteria and were included in
the final review. Most of the included studies were carried out in the United States (n=8; 67%) and
in areas of high HIV prevalence (n=11; 92%). Three (20%) were randomized control studies.
While the rate of newly diagnosed HIV cases varied widely (0.03-2.2%), likely due to methodological
heterogeneity between studies, the linkage of new HIV diagnosis was often high (80-100%)
and median CD4+ cell count was always greater than 200 cells per microliter. Targeted HIV screening
was found to be cost-effective (out of 2 studies) and well accepted by participants (out 2
studies).

Conclusions:
Targeted HIV screening at the ED can be impactful, feasible and well accepted, but
often requires extra funding and staff. Most previous work has focused on areas of high disease prevalence.
Role of Quercetin in the Mitigation of Lindane Induced Toxicity in Terms of Oxidative Responses and Metabolic Status in Mice Brain
Authors: Sharma Anupama , Bist Renu , Pareek Hemant 
Published: November 2020

Background:
The current study evaluated the protective potential of quercetin against
lindane induced toxicity in mice brain. For investigation, mice were allocated into four groups; the
first group was the control; the second group was administered with an oral dose of lindane (25
mg/kg bw) for 4 consecutive days; the third group was exposed to quercetin (40 mg/kg bw) and to
the fourth group, quercetin was administered 1 hour prior to the exposure of lindane.

Objective:
Two major objectives of the study were set . The first objective was to create lesions in
the brain by lindane and; the second was to evaluate the neuroprotective potential of quercetin.

Methods:
To study oxidative responses, the levels of thiobarbituric Acid Reactive Substances (TBARS),
Protein Carbonyl Content (PCC), Reduced Glutathione (GSH), Superoxide Dismutase
(SOD), Catalase (CAT), and Glutathione Peroxidase (GPx) were measured in brain homogenates.
Three key steps regulating enzymes of the Tricarboxylic Acid (TCA) cycle viz citrate synthase (CS),
pyruvate dehydrogenase (PDH) and fumarase were also assayed.

Results:
Lindane treatment significantly enhanced the levels of TBARS (P<0.001),PCC (P<0.001),
GPx (P<0.001), SOD (P<0.05), PDH (P<0.05) and fumarase (P<0.001) in brains of mice compared
to control. Meanwhile, it alleviated GSH, CAT and CS (P<0.05) activity.

Conclusion:
Pretreatment with quercetin in lindane treated group not only restored previously altered
biochemical parameters after lindane treatment and also significantly improved them, which
suggests that quercetin is not only safe rather is neuroprotective against lindane intoxication.
Identification of Therapeutic Drug Target of Stenotrophomonas maltophilia Through Subtractive Genomic Approach and in-silico Screening Based on 2D Similarity Filtration and Molecular Dynamic Simulation
Authors: Chandela Rahul , Jade Dhananjay , Mohan Surender , Sharma Ridhi , Sugumar Shobana 
Published: November 2020

Background:
Stenotrophomonas maltophilia is a multi-drug resistant, gram-negative
bacterium that causes opportunistic infections and is associated with high morbidity and mortality
in severely immunocompromised individuals.

Aim:
The study aimed to find out the drug target and a novel inhibitor for Stenotrophomonas
maltophilia.

Objectives:
The current study focused on identifying specific drug targets by subtractive genomes
analysis to determine the novel inhibitor for the specified target protein by virtual screening,
molecular docking, and molecular simulation approach.

Materials and Methods:
In this study, we performed a subtractive genomics approach to identify
the novel drug target for S.maltophilia. After obtaining the specific target, the next step was to
identify inhibitors that include calculating 2D similarity search, molecular docking, and molecular
simulation for drug development for S.maltophilia.

Results:
With an efficient subtractive genomic approach, five unique targets as the impressive therapeutics founded out of
4386 protein genes. In which UDP-D-acetylmuramic (murF) was the most remarkable target. Further virtual screening,
docking, and dynamics resulted in the identification of seven novel inhibitors.

Conclusion:
Further, in vitro and in vivo bioassay of the identified novel inhibitors could facilitate effective drug use against
S.maltophilia.
Analytical Solution and Consolidation Analysis of One-dimensional Large
Strain Consolidation Differential Equation
Authors: Su Huifeng , Liu Shijia , Yu Tao , Zhao Shuo , Cui Zhicheng 
Published: November 2020

Abstract::
According to the universal one-dimensional consolidation equation introduced by Gibson, the governing equation with the excess pore water pressure as the control variable is derived, and the Fourier series solution under the boundary condition of single-sided drainage is deduced in detail by the standard mathematical physical method. It verifies the correspondence between the analytical solution and the numerical solution from a theoretical point of view. Using this analytical solution, the nonlinear distribution of the excess pore pressure along the depth direction is obtained, and the traditional small strain consolidation is compared in terms of the average consolidation degree and the final settlement.

Soft soil foundation, large deformation foundation

Derive a consolidation equation for soft soils with large deformations using the super-static pore pressure as the control variable

Formula derivation, Example analysis

Based on Gibson's general equation of consolidation and its theory, the detailed derivation process of differential equations with excess pore water pressure as the control variable is given.

According to the example, the image shows the distribution of excess pore pressure with depth, and comparative analysis of large and small strains, If all other conditions are the same, When mv1=1 MPa-1, it can be calculated according to the large and small strains, but when mv1≥3MPa-1, the two errors are large, The calculation must be considered separately.
A Review on the Nutritional Aspects of Wild Edible Plants
Authors: Kaur Simran , Roy Arpita 
Published: November 2020

Abstract::
The world is facing many issues regarding malnutrition, lack of food security, unavailability
of food resources, and famines due to poor crop harvest, scarcity, and high cost of healthy
food. To overcome these situations, there is a need for an alternative that can effectively fulfill the
requirement of the world population. Wild edible plants (WEPs) are one of them, these plant species
are neither managed nor cultivated commercially, but utilized in many cultural, traditional, and
heritage practices all over the world. They are the sources of various essential nutrients like carbohydrates,
proteins, fats, minerals, etc., which can serve as an important source of nutrition in many
parts of the world especially, developing and under-developed countries. They have high nutritional
and medicinal properties, therefore utilized to cure a range of diseases like fever, injury, diarrhea,
boils, stomach ache, bleeding gums, toothaches, etc. WEPs are currently underutilized and
consumed traditionally by different communities. These foods lack recognition as a significant contributor
to the human diet in developed areas, which suggest more scientific exploration to make
their use common among people all over the world. Therefore, the aim of this review paper is to
document, compare, and contrast the nutritional and medicinal properties of selected fifty WEPs.
This review emphasizes diversity, ethnobotanical value, conservation, cultural as well as traditional
knowledge of wild edible plants (WEPs). Commercial exploitation and scientific scrutiny of WEPs
to develop dietary supplements, new food alterations, product development, pharmaceutical use,
and biofortification have also been discussed.
Is There Any Role of IL-6 Inhibition in COVID-19?
Authors: Cannon Rebecca , Das Satyajit 
Published: November 2020

:An emergent coronavirus, now named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a pandemic on the 22nd March 2020. It has since caused unprecedented pressures on the healthcare systems worldwide, leading to over five million cases and over three hundred thousand deaths. This has resulted in a global struggle to fight this disease, without any known cure or any definite treatment and with no vaccine. This challenge is exemplified by many with COVID-19 (Coronavirus Disease 2019) rapidly deteriorating to critical illness, developing respiratory failure, multi-organ dysfunction or failure, and septic shock. This rapid deterioration is thought to be due to the activation of the cytokine storm. The cytokine storm is characterised by mass cytokine and chemokine release, leading to widespread multi-organ damage. One of these such cytokines that plays a role in the cytokine storm is Interleukin (IL-) 6. Raised levels of IL-6 in many diseases have been observed to both correlate with disease severity and predict poor outcomes. Early studies began to show high levels of IL-6 in those with severe and critical COVID-19, and there is ongoing research into immune modulators to block IL-6, in the hope of halting disease progression and improving the chance of recovery. This article will explore the role that IL-6 plays in COVID-19 and whether an IL-6 blockade can prevent poor outcomes and reduce mortality.
Characterization of Multiple-bend Optical Fiber Extensometer Design for Landslide Sensor
Authors: Costrada Aldo Novaznursyah , Deswilan Sixtinah , Kemal Badrul Mustafa , Harmadi Harmadi 
Published: November 2020

Design of multiple-bend extensometer based on optical fiber as landslide sensor has been characterized. Multiple-bending characterization has been done by varying the winding number of optical fiber FD-620-10 to obtain the photodiode's effective light intensity.Â The light intensity in the extensometer was set by varying the laser diode resistance in the range (150 â€“ 250) Î©.Â The optimum sensitivity of 0.03984 V/cm was obtained for triple winding of optical fiber. The designed optical extensometer is able to monitor the displacement with an error of 0.59%. This result indicates that the designed extensometer is the more bending on optical fiber, the more its sensitivity and the bending loss.
Efektivitas Konseling Kelompok Ringkas Berfokus Solusi untuk mengembangkan konsep diri akademik Siswa
Authors: Sumini Sumini , Saputra Wahyu Nanda Eka , Suardiman Siti Partini 
Published: November 2020

Penelitian dilakukan untuk mengetahui efektifitas konseling kelompok ringkas berfokus solusi guna mengembangkan konsep diri akademik siswa kelas VIII SMP Negeri 3 Tanjungsari tahun ajaran 2018/2019. Menggunakan jenis penelitian Eksperimen, dengan desain pre-eksperimen, model yang digunakan adalah One-group pretest posttest design. Subjek dipilih dengan teknik Nonprobability Sampling Design menggunakan Purposive Sampling. Pemilihan subjek didapatkan 6 siswa dari kelas VIII SMP Negeri 3 Tanjungsari, yang kategori dari nilai skala konsep diri akademiknya rendah. Teknik pengumpulan daya yang digunakan adalah skala konsep diri akademik dan pedoman wawancara. Data terkumpul dalam bentuk kuantitatif (angka). Analisis secara statistik dilakukan menggunakan rumus t-test. Hasil penelitian dapat disimpulkan bahwa ada perbedaan signifikan antara tingkat konsep diri akademik siswa sebelum dan setelah diberikan perlakuan yaitu layanan konseling kelompok ringkas berfokus solusi.Â Abstract: This study aims to determine the effectiveness of solutions focused group brief counseling to develop academic self-concept of class VIII students of Tanjungsari State Junior High School 3 academic year 2018/2019. The type of research used was Experiments with the Pre-Experimental Design using the One-group pretest posttest design. Determination of the subject uses the Nonprobability Sampling Design technique using Purposive Sampling. The subjects of this study were 6 students from 8th grade of Tanjungsari State Junior High School 3, with a category of low academic self-concept scale values. The power collection techniques used are the scale of academic self-concept and interview guidelines. Data collected in quantitative form (numbers) are then analyzed statistically using the t-test formula. The results showed a significant difference between the level of academic self-concept of students before and after being given a solution-focused group counseling treatment.
An algorithm for interpreting the clinical significance of chromosomal microduplications in undifferentiated forms of intellectual disorders
Authors: Беляева Е.О. , Назаренко Л.П. , Лебедев И.Н. 
Published: November 2020

Идентификация хромосомных аномалий на субмикроскопическом уровне и установление их роли в этиологии интеллектуальных расстройств являются важной научной и практической задачей. Оценка патогенного значения менее изученного типа вариаций копийности ДНК - хромосомных микродупликаций представляет актуальный предмет для обсуждения. В исследовании предложен алгоритм интерпретации клинической значимости частичных трисомий, который является неотъемлемой составляющей в диагностике и профилактике хромосомных болезней.
The identification of chromosomal abnormalities at the submicroscopic level and the establishment of their role in the etiology of intellectual disorders are an important scientific and practical task. Evaluation of the pathogenic value of the less studied type of copy number variation - chromosomal microduplication - is an actual issue. The study proposed an algorithm for interpreting the clinical significance of partial trisomies, which is an integral component in the diagnosis and prevention of chromosomal diseases.