bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revision of the Oriental Chaetocnema species (Coleoptera, Chrysomelidae, Galerucinae, Alticini)
Authors: RUAN YONGYING , YANG XINGKE , KONSTANTINOV ALEXANDER S. , PRATHAPAN KANIYARIKKAL D. , ZHANG MENGNA 
Published: November 2019

The Oriental species of Chaetocnema Stephens, 1831 are revised. There are 85 valid species, including 19 new species: C. angustifrons sp. nov.; C. appendiculata sp. nov.; C. baoshanica sp. nov.; C. dapitanica sp. nov.; C. glabra sp. nov.; C. greenica sp. nov.; C. jinxiuensis sp. nov.; C. hongkongensis sp. nov.; C. latapronota sp. nov.; C. midimpunctata sp. nov.; C. nigrilata sp. nov.; C. parafusiformis sp. nov.; C. paragreenica sp. nov.; C. paraumesaoi sp. nov.; C. purerulea sp. nov.; C. reteimpunctata sp. nov.; C. sabahensis sp. nov.; C. subbasalis sp. nov.; C. trapezoida sp. nov. Fifteen new synonyms are proposed: C. assamensis Scherer, 1969 (syn. nov.) = C. hainanensis Chen, 1932; C. birmanica Jacoby, 1892 (syn. nov.) = C. malayana Baly, 1877; C. ebenina Warchalowski, 1973 (syn. nov.) = C. yiei Kimoto, 1970; C. flavipennis Medvedev, 1996 (syn. nov.) = C. granulicollis Jacoby, 1896; C. harita Maulik, 1926 (syn. nov.) = C. westwoodi Baly, 1877; C. himalayana Medvedev, 1993 (syn. nov.) = C. melonae Chen, 1934; C. kwangsiensis Chen, 1939 (syn. nov.) = C. hainanensis Chen, 1932; C. loriae Jacoby, 1905 (syn. nov.) = C. nigrica Motschulsky, 1858; C. nepalensis Scherer, 1969 (syn. nov.) = C. bella Baly, 1877; C. nitens Baly, 1877 (syn. nov.) = C. nigrica Motschulsky, 1858; C. placida Jacoby, 1896 (syn. nov.) = C. bella Baly 1877; C. shanensis Bryant, 1939 (syn. nov.) = C. bella Baly 1877; C. subcostata Jacoby, 1889 (syn. nov.) = C. wallacei Baly, 1877; C. vietnamica Chen & Wang, 1980 (syn. nov.) = C. modigliani Jacoby, 1896; C. vietnamica Medvedev, 2009 (syn. nov.) = C. wallacei Baly, 1877. C. vietnamica Medvedev, 2001 is a new junior homonym of C. vietnamica Chen & Wang, 1980. C. melonae Chen, 1934 status restored and resurrected from synonymy with C. duvivieri Jacoby, 1892 in Medvedev, 2001: 613. Two subspecies are raised to species level: C. taiwanensis Chûjô, 1965 new status for C. tonkinensis taiwanensis Chûjô, 1965 and C. yunnanica Heikertinger, 1951 new status for C. discreta yunnanica Heikertinger, 1951. Lectotypes are designated for 25 species: C. minuta Jacoby, 1896; C. granulicollis Jacoby, 1896; C. kwangsiensis Chen, 1939; C. longipunctata Maulik, 1926; C. montivaga Maulik, 1926; C. basalis Baly, 1877; C. parvula Baly, 1877; C. nitens Baly, 1877; C. geniculata Jacoby, 1896; C. simplicifrons (Baly, 1876); C. sticta Maulik, 1926; C. sumatrana Jacoby, 1896; C. wallacei Baly, 1877; C. alticola Maulik, 1926; C. belli Jacoby 1904; C. cognata Baly, 1877; C. squarrosa Baly, 1877; C. concinnipennis Baly, 1877; C. malayana Baly, 1877; C. birmanica Jacoby, 1892; C. merguiensis Bryant, 1941; C. pusaensis Maulik, 1926; C. singala Maulik, 1926; C. westwoodi Baly, 1877; C. harita Maulik, 1926.
Eye of the Storm: Observing Hurricanes with a Small Unmanned Aircraft System
Authors: Cione Joseph J. , Bryan George H. , Dobosy Ronald , Zhang Jun A. , de Boer Gijs , Aksoy Altug , Wadler Joshua B. , Kalina Evan A. , Dahl Brittany A. , Ryan Kelly , Neuhaus Jonathan , Dumas Ed , Marks Frank D. , Farber Aaron M. , Hock Terry , Chen Xiaomin 
Published: November 2019

AbstractUnique data from seven flights of the Coyote small unmanned aircraft system (sUAS) were collected in Hurricanes Maria (2017) and Michael (2018). Using NOAA’s P-3 reconnaissance aircraft as a deployment vehicle, the sUAS collected high-frequency (>1 Hz) measurements in the turbulent boundary layer of hurricane eyewalls, including measurements of wind speed, wind direction, pressure, temperature, moisture, and sea surface temperature, which are valuable for advancing knowledge of hurricane structure and the process of hurricane intensification. This study presents an overview of the sUAS system and preliminary analyses that were enabled by these unique data. Among the most notable results are measurements of turbulence kinetic energy and momentum flux for the first time at low levels (<150 m) in a hurricane eyewall. At higher altitudes and lower wind speeds, where data were collected from previous flights of the NOAA P-3, the Coyote sUAS momentum flux values are encouragingly similar, thus demonstrating the ability of an sUAS to measure important turbulence properties in hurricane boundary layers. Analyses from a large-eddy simulation (LES) are used to place the Coyote measurements into context of the complicated high-wind eyewall region. Thermodynamic data are also used to evaluate the operational HWRF model, showing a cool, dry, and thermodynamically unstable bias near the surface. Preliminary data assimilation experiments also show how sUAS data can be used to improve analyses of storm structure. These results highlight the potential of sUAS operations in hurricanes and suggest opportunities for future work using these promising new observing platforms.
Predictability of Midsummer Great Plains Low-Level Jet and Associated Precipitation
Authors: Malloy Kelsey M. , Kirtman Ben P. 
Published: November 2019

Abstract
Warm-season precipitation in the U.S. “Corn Belt,” the Great Plains, and the Midwest greatly influences agricultural production and is subject to high interannual and intraseasonal variability. Unfortunately, current seasonal and subseasonal forecasts for summer precipitation have relatively low skill. Therefore, there are ongoing efforts to understand hydroclimate variability targeted at improving predictions, particularly through its primary transporter of moisture: the Great Plains low-level jet (LLJ). This study uses the Community Climate System Model, version 4 (CCSM4), July forecasts, made as part of the North American Multi-Model Ensemble (NMME), to assess skill in reproducing the monthly Great Plains LLJ and associated precipitation. Generally, the CCSM4 forecasts capture the climatological jet but have problems representing the observed variability beyond two weeks. In addition, there are predictors associated with the large-scale variability identified through linear regression analysis, shifts in kernel density estimators, and case study analysis that suggest potential for improving confidence in forecasts. In this study, a strengthened Caribbean LLJ, negative Pacific–North American (PNA) teleconnection, El Niño, and a negative Atlantic multidecadal oscillation each have a relatively strong and consistent relationship with a strengthened Great Plains LLJ. The circulation predictors, the Caribbean LLJ and PNA, present the greatest “forecast of opportunity” for considering and assigning confidence in monthly forecasts.
The Identification of Postovulation Infertility with the Measurement of Early Luteal Phase (Peak Day +3) Progesterone Production
Authors: Hilgers Thomas W. 
Published: November 2019

This study reports on 632 cycles from 105 women who were using the CREIGHTON MODEL Fertility Care™ System to avoid pregnancy and had either a serious reason to avoid pregnancy or some degree of a lack of confidence. A progesterone level was drawn on the third day after the Peak Day as they were charting, and if the progesterone level was 2.3 ng/mL or greater, then ovulation was determined to have passed. If the level was greater than 3.0 ng/mL, this indicated that an absolute period of infertility had begun. In these cases, no pregnancies were observed. In the 27 cycles in which a specific follow-up relative to pregnancy could not be definitively determined, the progesterone levels in all cases were 2.3 ng/mL or greater with 23 of the 27 cycles being 3.1 ng/mL or greater. It is highly unlikely that any of those became pregnant as well. These cycles were collected over thirteen years (2004–2016). Two case presentations are also a part of this article of two families in which the couples had very serious reasons to avoid pregnancy. In these two couples, each of the women was multi-gravid and had no evidence of subfertility or infertility. They used the family planning progesterone level (the Peak Day +3 progesterone level) for a total of 167 cycles over a number of years successfully without a subsequent pregnancy. Summary: This article presents a thirteen-year effort to evaluate the serum progesterone level on the third day after the Peak Day as observed by women charting the CREIGHTON MODEL Fertility Care™ System. It is known that the Peak Day is associated with ovulation, and if the progesterone reaches a certain level, then an absolute period of infertility should follow. In fact, this is what this study reflects.
Exploring the Social Determinants of Drinking Sugary Beverages Leading to Chronic Illness Among Latina/o Populations
Authors: Khandelwal Priyanka , Salazar Leslie Ramos 
Published: November 2019

Introduction: The aim of this qualitative study was to assess Latina/o students’ sugary drink consumption patterns and understand the social determinants leading to this consumption behavior in order to design more effective health communication–based campaigns. This study examined the perceived reasons behind high levels of sugar-sweetened beverages (SSBs) consumption among college students of Hispanic origin in the Texas Panhandle region. Method: Fifteen Latina/o students were interviewed via an innovative social media–based online interviewing protocol. Results: Subsequent analyses revealed that peer pressure, socializing, unavailability of packaged drinking water during social events, targeted advertisements, and poor lifestyle choices were perceived reasons for high intake of SSB in the focal population. Conclusion: This study recommends designing public service announcements geared to Latino/a youth that increase awareness about the long-term health risks that can result from high consumption of SSBs. Moreover, the positive health benefits of drinking water should be highlighted and Latina/o parents should avoid glorifying SSBs and restrict their SSB consumption in front of their children. Further research should aim at designing educational messages, using theoretical backing, to test how Latina/o youth respond to them.
Associations of Partner Support and Acculturation With Physical Activity in Mexican American Women
Authors: Congello Neomie C. , Koniak-Griffin Deborah , Brecht Mary-Lynn , Hays Ron D. , Heilemann Mary-Sue V. , Nyamathi Adeline M. 
Published: November 2019

Introduction: Insufficient physical activity (PA) and obesity-related health conditions have reached epidemic proportions worldwide. Mexican American women (MAW) report low leisure time physical activity. Few studies examine activities beyond leisure time. Qualitative research suggests that partner support influence provides a cultural approach relevant to PA among MAW. Method: This cross-sectional study used an ecological model to investigate community (the physical environment), interpersonal (partner support, attitudinal familism), and intrapersonal (age, health conditions, acculturation, employment, and body mass index) factors associated with PA among 112 MAW. Community-based participatory research recommendations guided the preparatory phase of the study and the face-to-face interviews. Frequencies and descriptive statistics were computed. Multivariable linear regression analyses were used to examine associations between study variables. Results: Moderate to high PA levels were found based on combined activities performed during leisure time, transportation, household tasks, and occupational duties. Women with greater partner support reported higher PA levels. Although acculturation levels were low among women, those with higher acculturation were found to be more physically active. Conclusions: Future studies should examine strategies to increase partner support and address acculturation within intervention programs to enhance overall PA among MAW.
Hyperandrogenism associated with an ovarian remnant in a spayed female cat
Authors: Jones Sarah A , Owens Scott L , Birchard Stephen J 
Published: November 2019

Case summary An 11-year-old female, reportedly spayed, domestic shorthair cat was examined for a 4-month history of weight loss, aggression, urine spraying, malodorous urine and estrus-like behavior. Physical examination revealed thickened skin, a mildly prominent vulva and confirmed malodorous urine. On abdominal ultrasonography, a 6 mm hypoechoic nodule was found in the left cranial abdomen. An adrenocorticotropic hormone (ACTH) stimulation test with adrenal panel revealed elevated serum concentrations of androstenedione and testosterone pre- and post-cosyntropin stimulation, mildly decreased cortisol pre- and post-cosyntropin stimulation, and decreased resting aldosterone. Exploratory laparotomy was performed and a cystic, nodular mass was found in the region of the left ovary. The mass was surgically removed and submitted for histopathology; results were conclusive for an ovarian remnant with an intact corpus luteum and non-neoplastic parovarian cysts. Previously observed clinical signs resolved within two weeks of ovariectomy. A follow-up ACTH stimulation test with adrenal panel 6 weeks postoperatively revealed normalization of serum androstenedione, testosterone and cortisol concentrations. Four years postoperatively, at the time of writing, the cat remains free of clinical signs. Relevance and novel information We are unaware of any previously reported cases of non-neoplastic ovarian remnants associated with clinically relevant hyperandrogenism. A non-neoplastic ovarian-dependent hyperandrogenism should be included as a differential diagnosis of spayed female cats showing aggression and urine spraying behavior.
Novel Immunotherapeutic Approaches for Hodgkin Lymphoma
Authors: Savoldo Barbara , Grover Natalie S , Ramos Carlos A. , Dotti Gianpietro 
Published: November 2019

The outcome of patients with relapsed/refractory Hodgkin Lymphoma (HL) for whom salvage therapy or stem cell transplant have failed is poor. HL tumor cells (HRS) cells universally express CD30, which is an excellent target for directed therapy such as the antibody drug conjugate brentuximab vedotin (BV). Patients with relapsed HL can also respond to checkpoint inhibitors, emphasizing the susceptibility of this tumor to T-cell-mediated immune control. The adoptive transfer of chimeric antigen receptor T (CAR-T) cells, which combine antibody-mediated antigen specificity with the effector function and replication potential of T lymphocytes, offers the opportunity to infuse large numbers of T cells with defined antigen-specificity and MHC-independent tumor targeting. In two parallel and simultaneously conducted phase 1/2 dose-escalation studies, we administered CD30-specific CAR-T (CD30.CAR-T) cells after lymphodepletion to patients with HL that had relapsed after multiple lines of therapy, including BV, checkpoint inhibitors and stem cell transplant. We observed an excellent safety profile, with modest and self-limited cytokine release syndrome and no neurologic toxicity. The overall response rate was 78%, including 18 patients (67%) with complete responses, and the 1 year progression free survival was 47% (95% CI: 25% - 67%). Despite these promising results, unsolved obstacles include CAR-T cell trafficking and persistence in the tumor site. HL is characterized by a unique tumor microenvironment that creates a physical barrier and a hostile niche for CD30.CAR-T cells. Expression of PD-1 on CD30.CAR-T cells indicates that these cells likely remain susceptible to inhibition by PD-L1 in the tumor, and suggests that the combination of CD30.CAR-T cells with checkpoint blockade should be investigated. Enhancing CAR-T cell trafficking to tumor sites should also tip the delicate balance between effector and inhibitory mechanisms towards the former. Since the tumor microenvironment of HL is rich in TARC (thymus and activation regulated chemokine/CC chemokine ligand 17), we have initiated a clinical study in which CD30.CAR-T cells are further modified to co-express the cognate receptor (CCR4) for TARC to improve their tumor homing (NCT03062157).

Disclosures
Savoldo: Baylor College of Medicine: Patents & Royalties: CAR.CD30 patent; Bluebirdbio: Other: research agreement; Cell Medica: Other: Research Agreement; Bellicum: Other: Research Agreement. Grover:Seattle Genetics: Consultancy. Ramos:Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Tessa Therapeutics: Research Funding.
Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells
Authors: Lim Wendell 
Published: November 2019

CAR T cells have shown remarkable outcomes when targeting specific hematologic cancers. But targeting solid cancers has proven difficult: it is difficult to identify unique antigens, to traffic to tumors, and to mount a strong response in the solid tumor microenvironment. To overcome these issues, we are using the approaches of synthetic biology to engineer next-generation T cells. We are engineering cells that utilize new sets of sensors and modular control circuits that enable them to execute new recognition and response programs with higher precision and robustness. These new capabilities may allow us to develop therapeutic T cells that are far more effective and safe against solid tumors.

Disclosures
Lim: Cell Design Labs: Other: founder of Cell Design Labs; acquired by Gilead in 2017; Allogene: Consultancy.
Activation of the Receptor Tyrosine Kinase (RET) By GDNF/GFRα1 Improves Cord Blood-Derived HSC in Vitro expansion and In Vivo engraftment
Authors: Grey William , Chauhan Rakhee , Garcia-Albornoz Manuel , Huerga Encabo Hector , McDonald Neil , Bonnet Dominique 
Published: November 2019

Allogeneic hematopoietic stem cell (HSC) transplantation is the gold standard therapy for numerous hematological disorders, but limitations exist in HSC number available per donor and our relative inability to successfully expand transplantable HSCs in vitro. In recent years, promising new molecules have been discovered, which are able to expand HSCs in vitro and improve transplantation in vivo in immunodeficient mouse models and non-human primates (e.g. SR1 and UM171).
Here we demonstrate that acute activation of the receptor tyrosine kinase, RET, by its key ligand and co-receptor (GDNF/GFRα1), significantly improves the outgrowth of HSCs invitro and long-term engraftment in immunodeficient Kit-mutant (KitW41/W41) mice.
The expression of RET at the cell surface of cord blood-derived hematopoietic stem and progenitor cells (HSPCs, CD34+CD38-REThi) enriches for stem cell frequency in limiting dilution transplantation assays (~1 in 135), with CD34+CD38-RETlow cells showing low stem cell frequency with limited multilineage engraftment (~1 in 531). Activation of RET in vitro with a single dose of GDNF/GFRα1 reduces apoptosis at early time points, leading to increased HSC expansion over a 7-day period (>4-fold increase vs control). Transplantation of GDNF/GFRα1 treated HSPCs significantly improves engraftment of primary mice, comparable to the previously published SR1/UM171 treatment, and combination treatment of GDNF/GFRα1 with SR1/UM171 improves engraftment compared to individual GDNF/GFRα1 or SR1/UM171 treatments alone.
RET is a single pass transmembrane receptor tyrosine kinase, governing a variety of downstream signalling pathways. Interrogation of the dynamic kinome changes governed by RET in HSPCs, using PAMGene kinome array kinetic technology and single cell mass cytometry revealed key phosphorylation cascades responsive to GDNF/GFRα1 treatment. Key cascades including anti-apoptotic p53 phosphorylation, NFκB activation and increased CD44 cell surface expression, revealed important cellular programs for HSC survival, outgrowth and engraftment activated by GDNF/GFRα1.
Our results provide a promising new target to improve the outgrowth of transplantable HSCs for clinical use, with multiple downstream functions activated for successful transplantation.

Disclosures
No relevant conflicts of interest to declare.
Prophylactic Donor Lymphocyte Infusion for Relapse Prevention; A Meta-Analysis
Authors: Poonsombudlert Kittika , Kewcharoen Jakrin , Prueksapraopong Chattip , Nath Limpruttidham 
Published: November 2019

Objective: relapsed hematologic malignancies after standard hematopoietic stem cell transplant (HSCT) is one of the most challenging diseases to treat, therefore ongoing research are aiming at relapse prevention and minimizing the transplant related side effects. Prophylactic donor lymphocytes (pDLI) had been proposed as a valuable strategy for relapse prevention but early study results had been discouraging due to association with acute graft-versus-host disease (aGVHD). We attempted to establish the efficacy of pDLI for relapse prevention and define its association with aGVHD.
Method: we searched for titles of articles in MEDLINE (PubMed), Cochrane library, EMBASE database and Google Scholar in May 2019 that evaluated the association between pDLI, relapse and aGVHD. We conducted a random effect meta-analysis of 9 studies involving a total of 748 participants and reported the pooled odd ratio (OR) for incidence of relapse and aGVHD between patients in the pDLI group and the control group.
Result: we found a significantly decreased risk of relapse in the pDLI group versus the control group with a pooled OR of 0.42, 95% CI 0.30-0.58, I2=0% while there is no significantly increased in the risk of aGVHD with a pooled OR of 0.98, 95% CI 0.56-1.72, I2=0.8%
Conclusion: there is significantly decreased risk of relapse in the pDLI group compared to the control group but there is no statistically significant increased risk of aGVHD. We concluded that pDLI is a valuable method of post-transplant relapse prevention for hematologic malignancies and further research is encouraged in a larger population.

Disclosures
No relevant conflicts of interest to declare.