bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD59 receptor targeted delivery of miRNA-1284 and cisplatin-loaded liposomes for effective therapeutic efficacy against cervical cancer cells
Authors: Wang Li , Liang Ting-Ting 
Published: March 2020

AbstractCo-delivery of two different therapeutics (miRNA-1284 and cisplatin (CDDP)) into the cancer cells in a single nanocarrier provides new dimension to the cancer treatment. In this study, we have designed the CD59sp-conjugated miRNA-1284/cisplatin(CDDP)-loaded liposomes for the enhanced therapeutic effect against cervical cancers. Compared with miRNA-1284/CDDP-loaded liposomes (LP-miCDDP), CD59 antibody-conjugated LP-miCDDP (CD/LP-miCDDP) showed a significantly higher cytotoxicity in HeLa cells. Notably, MiR-1284 showed a typical concentration-dependent cell killing effect in the cervical cancer cells owing to the downregulation of HMGB1. Flow cytometer analysis showed that CD/LP-miCDDP resulted in maximum apoptosis effect (~ 60%) compared to CDDP (~ 20%) or miR-1284 (~ 12%) treated cells indicating the superior anticancer effect in the cancer cells. Importantly, CD/LP-miCDDP significantly prolonged the blood circulation of encapsulated drug in rats with AUC(o-t) of CD/LP-miCDDP showed a 6.9 fold higher value than that of free CDDP. Similarly, CD/LP-miCDDP showed an eightfold decrease in the clearance (CL) and 3.6-fold higher t1/2 compared to that of free CDDP. Overall, results demonstrated that targeted and synergistic co-delivery of therapeutic components could be promising in cervical cancer therapy.
Evaluation of stability of swipe gesture authentication across usage scenarios of mobile device
Authors: Ellavarason Elakkiya , Guest Richard , Deravi Farzin 
Published: March 2020

Abstract
Background
User interaction with a mobile device predominantly consists of touch motions, otherwise known as swipe gestures, which are used as a behavioural biometric modality to verify the identity of a user. Literature reveals promising verification accuracy rates for swipe gesture authentication. Most of the existing studies have considered constrained environment in their experimental set-up. However, real-life usage of a mobile device consists of several unconstrained scenarios as well. Thus, our work aims to evaluate the stability of swipe gesture authentication across various usage scenarios of a mobile device.

Methods
The evaluations were performed using state-of-the-art touch-based classification algorithms—support vector machine (SVM), k-nearest neighbour (kNN) and naive Bayes—to evaluate the robustness of swipe gestures across device usage scenarios. To simulate real-life behaviour, multiple usage scenarios covering stationary and dynamic modes are considered for the analysis. Additionally, we focused on analysing the stability of verification accuracy for time-separated swipes by performing intra-session (acquired on the same day) and inter-session (swipes acquired a week later) comparisons. Finally, we assessed the consistency of individual features for horizontal and vertical swipes using a statistical method.

Results
Performance evaluation results indicate impact of body movement and environment (indoor and outdoor) on the user verification accuracy. The results reveal that for a static user scenario, the average equal error rate is 1%, and it rises significantly for the scenarios involving any body movement—caused either by user or the environment. The performance evaluation for time-separated swipes showed better verification accuracy rate for swipes acquired on the same day compared to swipes separated by a week. Finally, assessment on feature consistency reveal a set of consistent features such as maximum slope, standard deviation and mean velocity of second half of stroke for both horizontal and vertical swipes.

Conclusions
The performance evaluation of swipe-based authentication shows variation in verification accuracy across different device usage scenarios. The obtained results challenge the adoption of swipe-based authentication on mobile devices. We have suggested ways to further achieve stability through specific template selection strategies. Additionally, our evaluation has established that at least 6 swipes are needed in enrolment to achieve acceptable accuracy. Also, our results conclude that features such as maximum slope and standard deviation are the most consistent features across scenarios.
Local differential privacy for human-centered computing
Authors: Fang Xianjin , Zeng Qingkui , Yang Gaoming 
Published: March 2020

AbstractHuman-centered computing in cloud, edge, and fog is one of the most concerning issues. Edge and fog nodes generate huge amounts of data continuously, and the analysis of these data provides valuable information. But they also increase privacy risks. The personal sensitive data may be disclosed by untrusted third-party service providers, and the current solutions to privacy protection are inefficient, costly. It is difficult to obtain available statistics. To solve these problems, we propose a local differential privacy sensitive data collection protocol in human-centered computing. Firstly, to maintain high data utility, the selection of the optimal number of hash functions and the mapping length is based on the size of the collected data. Secondly, we hash the sensitive data, add the appropriate Laplace noise to the client side, and send the reports to the server side. Thirdly, we construct the count sketch matrix to obtain privacy statistics on the server side. Finally, the utility of the proposed protocol is verified by synthetic datasets and a real dataset. The experimental results demonstrate that the protocol can achieve a balance between data utility and privacy protection.
Rates of compliance and adherence to high-intensity interval training in insufficiently active adults: a systematic review and meta-analysis protocol
Authors: Santos Alexandre , Lonsdale Chris , Lubans David , Vasconcellos Diego , Kapsal Nathanial , Vis-Dunbar Mathew , Jung Mary E. 
Published: March 2020

Abstract
Background
Both high-intensity interval training and moderate-intensity continuous training demonstrate beneficial physiological outcomes for active and insufficiently active populations. However, it remains unclear whether compliance to exercise in supervised settings translates to long-term adherence to physical activity in real-world, unstructured environments. To our knowledge, no comprehensive review is available on compliance and/or adherence rates to either modes of exercise for insufficiently active individuals. Furthermore, it is unclear which training modality insufficiently active individuals comply and/or adhere more readily to. Based on these gaps, the following two questions will be addressed: (1) What are compliance and adherence rates to high-intensity interval training for insufficiently active adults aged 18–65 years and (2) How do compliance and adherence rates differ between high-intensity interval training and moderate-intensity continuous training?

Methods
Both observational and experimental studies that report on compliance and/or adherence rates to high-intensity interval training will be included. Relevant studies will be retrieved from Medline, EMBASE, PsychINFO, SPORTDiscus, CINAHL, and Web of Science using a pre-specified search strategy. Pre-defined inclusion and exclusion criteria will be used by two independent researchers to determine eligible studies. Of those meeting the inclusion criteria, data extraction and narrative synthesis will be completed, and where applicable, random-effects meta-analyses will be computed to compare compliance and adherence rates between high-intensity interval training and moderate-intensity continuous training. Meta-regressions and sensitivity analyses will be used to further explore factors that could influence aggregate effect sizes. Risk of bias will be assessed using established tools by the Cochrane association, and quality assessment of the cumulative evidence will be assessed using the GRADE approach.

Discussion
Results from this study may have the potential to inform future physical activity recommendations and guidelines on the ideal mode of exercise for the general population. This review will add to the body of literature on the feasibility of high-intensity interval training for an insufficiently active population, conclusively addressing the ongoing debate of whether it is an appropriate exercise choice for this demographic. With this new information, individuals working towards a healthier lifestyle through physical activity engagement may be better equipped to make an evidence-based decision.

Systematic review registration
This review has been registered in the PROSPERO database and assigned the identifier CRD42019103313.
The existence of ground state solution to elliptic equation with exponential growth on complete noncompact Riemannian manifold
Authors: Liu Chungen , Liu Yanjun 
Published: March 2020

AbstractIn this paper, we consider the following elliptic problem: $$ -\mathtt{div}_{g}\bigl( \vert \nabla_{g} u \vert ^{N-2}\nabla_{g} u \bigr)+V(x) \vert u \vert ^{N-2}u = \frac{f(x, u)}{a(x)}\quad \mbox{in } M, \qquad (P_{a}) $$−divg(|∇gu|N−2∇gu)+V(x)|u|N−2u=f(x,u)a(x)in M,(Pa) where $(M, g)$(M,g) be a complete noncompact N-dimensional Riemannian manifold with negative curvature, $N\geq2$N≥2, V is a continuous function satisfying $V(x) \geq V_{0 }> 0$V(x)≥V0>0, a is a nonnegative function and $f(x, t)$f(x,t) has exponential growth with t in view of the Trudinger–Moser inequality. By proving some estimates together with the variational techniques, we get a ground state solution of ($P_{a}$Pa). Moreover, we also get a nontrivial weak solution to the perturbation problem.
Global asymptotic stability for a nonlinear density-dependent mortality Nicholson’s blowflies system involving multiple pairs of time-varying delays
Authors: Xu Yanli , Cao Qian 
Published: March 2020

AbstractIn our article, a nonlinear density-dependent mortality Nicholson’s blowflies system with patch structure has been investigated, in which the delays are time-varying and multiple pairs. Based upon the fluctuation lemma and differential inequality techniques, some sufficient conditions are found to ensure the global asymptotic stability of the addressed model. Moreover, a numerical example is provided to illustrate the feasibility and effectiveness of the obtained findings, and our consequences are new even when the considered model degenerates to the scalar Nicholson’s blowflies equation.
Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
Authors: Dinku Worku , Isaksson Johan , Rylandsholm Fredrik Garnås , Bouř Petr , Brichtová Eva , Choi Sang Un , Lee Sang-Ho , Jung Young-Sik , No Zae Sung , Svendsen John Sigurd Mjøen , Aasen Arne Jørgen , Dekebo Aman 
Published: March 2020

AbstractMyrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3,30-dihydroxypodioda-7,17,21-trien-4-carboxylic acid (commafric A) has been isolated from a crude methanolic extract of Commiphora africana (A. Rich.) Engl. resin along with the known pentacyclic triterpene α-amyrin. The structure of commafric A was characterized using different spectroscopic techniques such as 1D and 2D NMR, IR, and VCD combined with computations. The anti-proliferative activity of both isolated compounds was evaluated using SRB based colorimetric cellular assay against four human cancer cell lines. Etoposide was used as a positive control. Commafric A showed significant anti-proliferative effects against non-small cell lung cancer (A549) with IC50 values of 4.52 μg/ml. The pentacyclic triterpene α-amyrin showed a weak anti-proliferative activity against A2780 (ovarian cancer), MIA-PaCa-2 (pancreatic cancer), and SNU638 (stomach cancer) cell lines tested with IC50 values ranging 9.28 to 28.22 μg/ml. Commafric A possessed anti-proliferative activity against non-small cell lung cancer (A549), which suggests that commafric A has potential to be further optimized being a lead compound in the search for new drugs against cancer diseases.
MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome
Authors: Wu Shanshan , Sun Huijuan , Sun Bin 
Published: March 2020

Abstract
Background
Acute coronary syndrome (ACS) is a serious type of cardiovascular diseases. This study aimed to investigate the expression patterns and clinical value of microRNA-145 (miR-145) in ACS patients, and further uncover the function of miR-145 in ACS rats.

Methods
Quantitative real-time PCR was used to estimate the expression of miR-145. Diagnostic value of miR-145 was evaluated, and its correlation with endothelial injury marker (vWF and H-FABP) and pro-inflammatory cytokines (IL-6 and TNF-α) was analyzed. Coronary artery ligation was adopted to construct the ACS rat model, and the effects of miR-145 on endothelial injury, inflammation and vascular endothelial cells (VECs) biological function were examined.

Results
Downregulated expression of miR-145 was found in the ACS serum samples compared with the healthy controls. The expression of miR-145 was proved to be a diagnostic biomarker and negatively correlated with vWF, H-FABP, IL-6 and TNF-α. The similar serum expression trends of miR-145 in ACS patients were also observed in the ACS rats, and the overexpression of miR-145 could decrease the elevated vWF, H-FABP, IL-6 and TNF-α in the animal model. Moreover, the upregulation of miR-145 in VECs led to promoted proliferation and migration. The bioinformatics prediction data and luciferase report results indicated that FOXO1 was a direct target of miR-145.

Conclusions
In conclusion, it was hypothesized that serum decreased expression of miR-145 may serve as a potential diagnostic biomarker in ACS patients. Overexpression of miR-145 may improve the endothelial injury and abnormal inflammation through targeting FOXO1, indicating that miR-145 serves as a candidate therapeutic target of ACS.
Outcome of catheter ablation of non-reentrant ventricular arrhythmias in patients with and without structural heart disease
Authors: Schleberger Ruben , Jularic Mario , Salzbrunn Tim , Hacke Claudia , Schwarzl Jana M. , Hoffmann Boris A. , Steven Daniel , Willems Stephan , Lemoine Marc D. , Meyer Christian 
Published: March 2020

Abstract
Background
Catheter ablation of non-reentrant, commonly termed “idiopathic” ventricular arrhythmias (VA) is highly effective in patients without structural heart disease (SHD). Meanwhile, the outcome of catheter ablation of these arrhythmias in patients with SHD remains unclear. This study sought to characterize the outcome of patients with and without SHD undergoing catheter ablation of non-reentrant VA.

Methods
In this single-centre study the acute and long-term outcome of 266 consecutive patients undergoing catheter ablation of non-reentrant VA was investigated. In 41.0% of patients a SHD was present (n = 109, 80.7% male, age 59.1 ± 14.7 years), 59.0% had no SHD (n = 157; 44.0% male, age 49.9 ± 16.5 years).

Results
Acute procedural success (absence of spontaneous or provoked VA at the end of procedure and within 48 h after the procedure) was achieved in 89.9% of patients with SHD vs. 94.3% without SHD (p = 0.238). During a mean follow-up of 34.7 ± 15.1 months a repeat catheter ablation was performed in 19.6% of patients with SHD vs. 13.0% without SHD (p = 0.179). Patients with dilated cardiomyopathy (DCM) were the most likely to require a repeat ablation procedure (32.0% of patients with DCM vs. 13.0% without SHD; p = 0.022). Periprocedural complications occurred in 5.5% of patients with SHD vs. 5.7% without SHD (p > 0.999). All complications were managed without sequelae.

Conclusions
The outcome of catheter ablation of non-reentrant VA in patients with SHD appears good and is comparable to patients without SHD. A slightly higher rate of repeat ablations was observed in patients with DCM.
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review
Authors: Adhikari Sasmita Poudel , Meng Sha , Wu Yu-Ju , Mao Yu-Ping , Ye Rui-Xue , Wang Qing-Zhi , Sun Chang , Sylvia Sean , Rozelle Scott , Raat Hein , Zhou Huan 
Published: March 2020

Abstract
Background
The coronavirus disease (COVID-19) has been identified as the cause of an outbreak of respiratory illness in Wuhan, Hubei Province, China beginning in December 2019. As of 31 January 2020, this epidemic had spread to 19 countries with 11 791 confirmed cases, including 213 deaths. The World Health Organization has declared it a Public Health Emergency of International Concern.

Methods
A scoping review was conducted following the methodological framework suggested by Arksey and O’Malley. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. The research domains, dates of publication, journal language, authors’ affiliations, and methodological characteristics were included in the analysis. All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.

Results
Most of the publications were written using the English language (89.2%). The largest proportion of published articles were related to causes (38.5%) and a majority (67.7%) were published by Chinese scholars. Research articles initially focused on causes, but over time there was an increase of the articles related to prevention and control. Studies thus far have shown that the virus’ origination is in connection to a seafood market in Wuhan, but specific animal associations have not been confirmed. Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. Preventive measures such as masks, hand hygiene practices, avoidance of public contact, case detection, contact tracing, and quarantines have been discussed as ways to reduce transmission. To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care.

Conclusions
There has been a rapid surge in research in response to the outbreak of COVID-19. During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. Although these studies are relevant to control the current public emergency, more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short- and long-term.
A continuum model for slip transfer at grain boundaries
Authors: Fressengeas Claude , Upadhyay Manas V. 
Published: March 2020

AbstractUsing a continuous representation of dislocations in elastoplastic polycrystals, we investigate slip transfer at grain boundaries by assessing the compatibility of the slip system shear rates with tangential continuity of the plastic distortion rate tensor at these interfaces. Fulfillment of this tangential continuity condition is needed for consistency of the continuous description of dislocations in polycrystals. We show that, in f.c.c. materials at moderate temperatures, this condition unequivocally translates into constraints on the slip rates on both sides of grain boundaries. Appended to the elastoplastic boundary value problem, it allows a complete determination of the slip system shear rates. An algorithm enabling the implementation of compatible slip transfer in both the finite element methods and the spectral methods based on Fast Fourier Transforms is provided in both standard crystal plasticity and the mechanics of dislocations fields.
rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform
Authors: Mun Seok Gyu , Choi Hyung Woo , Lee Jong Min , Lim Jae Hyun , Ha Jang Ho , Kang Min-Jung , Kim Eun-Joong , Kang Lifeng , Chung Bong Geun 
Published: March 2020

AbstractWe developed the microfluidic co-culture platform to study photothermal therapy applications. We conjugated folic acid (FA) to target breast cancer cells using reduced graphene oxide (rGO)-based functional nanomaterials. To characterize the structure of rGO-based nanomaterials, we analyzed the molecular spectrum using UV–visible and Fourier-transform infrared spectroscopy (FT-IR). We demonstrated the effect of rGO-FA-based nanomaterials on photothermal therapy of breast cancer cells in the microfluidic co-culture platform. From the microfluidic co-culture platform with breast cancer cells and human umbilical vein endothelial cells (HUVECs), we observed that the viability of breast cancer cells treated with rGO-FA-based functional nanomaterials was significantly decreased after near-infrared (NIR) laser irradiation. Therefore, this microfluidic co-culture platform could be a potentially powerful tool for studying cancer cell targeting and photothermal therapy.