bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between Age, Oral Health-Related Quality of Life, and Oral and Swallowing Function among Psychiatric Inpatients in Japan : a cross-sectional study
Authors: Haresaku Satoru , Nakashima Fuyuko , Hara Yayoi , Kuroki Madoka , Aoki Hisae , kubota Keiko , Naito Toru 
Published: June 2020

Abstract
【Background】Along with the ageing society, hospitalized psychiatric patients are also ageing in Japan. The purpose of this study was to investigate the associations between age, oral health-related quality of life (OHRQoL), and oral health, including oral and swallowing function, among psychiatric inpatients. 【Methods】The subjects included 165 psychiatric inpatients in two psychiatric hospitals in Japan. The General Oral Health Assessment Index (GOHAI) and the Eating Assessment Tool (EAT-10) were included in the questionnaire survey for the measurement of OHRQoL and swallowing function. A score ≥3 on the EAT-10 was defined as suspected dysphagia. Oral examinations and oral diadochokinesis (ODK) measurements for the tongue-lip motor function evaluation were conducted. A chi-squared test, the Mann-Whitney U test, and linear regression analysis were used for the analysis. 【Results】A total of 100 (64.5%) psychiatric inpatients (49 males and 51 females) participated in this study. Their mean±SD age was 67.3±14.5. The higher DMFT index, the lower tongue-lip function, and suspected dysphagia was significantly associated with the higher age group. Tooth loss and suspected dysphagia were significantly associated with low GOHAI scores. The EAT-10 score was significantly correlated with the GOHAI score only after adjusting for age and sex (β=-0.725, 95% CI:-0.97, -0.64). 【Conclusions】In hospitalized psychiatric patients, impaired oral health in the older subjects was more pronounced compared with that among general adults. Tooth loss and swallowing function were associated with OHRQoL. Therefore, oral care for the recovery of occlusal and swallowing functions may be needed to improve OHRQoL among psychiatric patients.
Acute Superior Mesenteric Artery Embolism treated with Percutaneous Mechanical Thrombectomy: Preliminary application and Experience
Authors: Xu Qiyang , Wang Yi , Wang Di , Xu Bin , Yang Leibo , Hu Songjie , Yan Jinlin , Lang Dehai 
Published: June 2020

Abstract
Background:Acute superior mesenteric artery embolism is a life-threatening disease and the prognosis is very poor. Few reports have described the application of Percutaneous Mechanical Thrombectomy in Acute superior mesenteric artery embolism. In the article, we show a series of cases treated with Percutaneous Mechanical Thrombectomy and share our experience.Methods:Review and analyze seven patients with acute superior mesenteric artery embolism treated by Angiojet Ultra thrombectomy system in our institution. Based on the literature, we summarize the diagnosis, treatment and surgical experience of acute superior mesenteric artery embolism. Results:Percutaneous Mechanical Thrombectomy were achieved successfully in all the patients without surgical complication occurred. Five patients’ symptoms relieved significantly and smoothly discharged from the hospital. Two patients still complained of abdominal pain after operation. One patient underwent surgical laparotomy and intestinal resection and the other one abandoned surgical treatment. During the first six months of follow-up, six patients were free of any clinical symptoms or signs and one patient who refused laparotomy died two days later with septic shock.Conclusion:Percutaneous Mechanical Thrombectomy by Angiojet Ultra thrombectomy system is a safe, effective and minimally invasive method in the initial stage of acute superior mesenteric artery embolism. We believe Percutaneous Mechanical Thrombectomy could be a promising alternative in selected cases. Furthermore, large sample data and long term follow-up are needed to verify its effect.
Exploring the Mechanisms of Lian Hua Qing Wen Capsule against COVID-19 by Network Pharmacology and Molecular Docking Approach
Authors: Chen Li , Qu Hua , Tan Yu , Wu Tao Han , Shi Zhuo Da 
Published: June 2020

Abstract
Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) disease has led to a wide-spread global pandemic. There is no specific antiviral drug proven effective for the treatment of patients with COVID-19 at present. Combination of western and traditional Chinese medicine (TCM) is recommended, and Lian Hua Qing Wen (LHQW) capsule is a basic prescription and widely used to treat COVID-19 in China. However, the mechanisms of LHQW capsule treating COVID-19 are not clear. The aim of the study is to explore the mechanisms of LHQW capsule treating COVID-19 based on network pharmacy and molecular docking approach. Methods The active compounds and targets of LHQW capsule were obtained from traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). COVID-19 related target genes were obtained from GeneCards database and OMIM database. Protein–protein interaction (PPI) networks of LHQW capsule targets and COVID-19-related genes were visualized and merged to identify the candidate targets for LHQW capsule treating COVID-19. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were also performed. The hub genes involved in the gene-related pathways were screened and their corresponding compounds were used for in vitro validation of molecular docking predictions.Results A total of 185 active compounds of LHQW capsule were screened out, and 263 targets were predicted. Third hundred and fifty-two COVID-19 related target genes were obtained from GeneCards database and OMIM database. GO functional enrichment analysis showed that the biological processes of LHQW capsule treating COVID-19 were closely linked with the regulation of inflammation, immunity, cytokines production, vascular permeability, oxidative stress and apoptosis. KEGG enrichment analysis revealed that the pathways of LHQW capsule treating COVID-19 were significantly enriched in AGE−RAGE signaling pathway in diabetic complications, Kaposi sarcoma−associated herpesvirus infection, TNF, IL−17, and Toll−like receptor (TLR) signaling pathway. The hub targets genes in the gene-related pathways analysis of LHQW capsule treating COVID-19 included MAPK1, MAPK3, RELA, IL-6 and CASP8, which closely associated with inflammation, cytokines storm and apoptosis. Finally, molecular docking showed that top 5 compounds of LHQW capsule also had good binding activities to the important targets in COVID-19.Conclusions The mechanisms of LHQW capsule treating COVID-19 may involve in inhibiting inflammatory response, cytokine storm and virus infection, and regulating immune reactions, apoptosis and endothelial barrier.
A Novel Immunochromatographic Test Strip Versus A Commercial Rapid Diagnostic Test for the Detection of Imported Plasmodium Species in Guangxi Province, China: A Comparative Evaluation
Authors: kangming lin , Wang Duo-Quan , Kokouvi Kassegne , Wang Jun-Yun , Shi Feng , Qian Ying-Jun , Qin Jian , Chen Jian-Feng , Ma An-Xiang , Li Jun , Yang Yi-Chao , Abilahi Faraji , Mihayo Michael , Lu Shen-Ning , Yang Fan , Zhou Xiao-Nong , Li Shi Zhu 
Published: June 2020

Abstract
Background: China has made significant progress towards malaria elimination by achieving zero reports of indigenous malaria cases over two consecutive years. The diagnosis of malaria, which is based on microscopic examination, still remains a challenge, due to a lack of sensitivity for detecting low-level parasitaemia. This study aimed to evaluate the diagnostic value of a novel immunochromatographic test strip for imported malaria. Methods: After obtaining informed consent, blood samples were collected from migrants returning home from Africa to Shanglin County in Guangxi, PR China, in 2018-2019, and were tested with the novel test strips. The test results were compared with those of microscopic examination, commercial malaria rapid diagnostic test (RDT), and polymerase chain reaction (PCR) assay. Results: A total of 535 samples were tested. Both microscopy and PCR test results showed a total of 162 (30.28%) malaria-positive samples, of which 99 were positive for Plasmodium falciparum (P. falciparum), three for P. vivax, five for P. malariae, and 50 for P. ovale, whereas five had mixed infections. The sensitivity, specificity, and efficiency of the novel RDT were 74.1%, 93.0%, and 87.3%, respectively, whereas its sensitivity of detecting P. falciparum, P. vivax, P. malariae, and P. ovale was 91.9%, 100%, 20.0%, and 44.0%, respectively. Furthermore, the sensitivity, specificity, and efficiency of the commercial RDT were 86.0%, 89.3%, and 88.2%, respectively, whereas its sensitivity of detecting P. falciparum, P. vivax, P. malariae, and P. ovale was 96.0%, 100%, 40.0%, and 70.0% respectively. The differential detection of Plasmodium species using the new RDT was significantly better compared to that of the commercial RDT (c2 = 14.73; P = 0.0001), which can detect only P. falciparum. This was consistent with Kappa analysis (Kappa = 0.881). A significant difference (c2 = 24.50; P < 0.0001) in the detection rate of other Plasmodium species was observed with an average consistency using Kappa analysis (Kappa = 0.716). Conclusion: The novel malaria RDT test strip had high sensitivity and specificity in detecting P. falciparum and P. vivax. Improvement in P. ovale and P. malariae detection efficiency may lead to the scale-up of this RDT in the future.
Hygiene along the continuum of care in the early post-natal period: an observational study in Nigeria
Authors: Nalule Yolisa , Buxton Helen , Flynn Erin , Oluyinka Olutunde , Sara Stephen , Cumming Oliver , Dreibelbis Robert 
Published: June 2020

Abstract
Background
Newborns delivered in healthcare facilities in low- and middle-income countries are at an increased risk of healthcare associated infections. Facility–based studies have focused primarily on healthcare worker behaviour during labour & delivery with limited attention to hygiene practices in post-natal care areas and largely ignore the wide variety of actors involved in maternal and neonatal care.
Methods
This exploratory mixed-methods study took place in six healthcare facilities in Nigeria where 31 structured observations were completed during post-natal care, discharge, and the first six hours after return to the home. Frequency of hand hygiene opportunities and hand hygiene actions were assessed for types of patient care (maternal and newborn care) and the role individuals played in caregiving (healthcare workers, cleaners, non-maternal caregivers). Qualitative interviews with mothers were completed approximately 1 week after facility discharge.
Results
Maternal and newborn care were performed by a range of actors including healthcare workers, mothers, cleaners and non-maternal caregivers. Of 291 hand hygiene opportunities observed at health facilities, and 459 observed in home environments, adequate hand hygiene actions were observed during only 1% of all hand hygiene opportunities. Adequate hand hygiene prior to cord contact was observed in only 6% (1/17) of cord contact related hand hygiene opportunities at healthcare facilities and 7% (2/29) in households. Discharge advice was infrequent and not standardised and could not be remembered by the mother after a week. Mothers reported discomfort around telling non-maternal caregivers to practice adequate hand hygiene for their newborn.
Conclusions
In this setting, hand hygiene practices during post-natal care and the first six hours in the home environment were consistently inadequate. Effective strategies are needed to promote safe hand hygiene practices within the post-natal care ward and home in low resource, high-burden settings. Such strategies need to target not just mothers and healthcare workers but also other caregivers.
Regional Robust Secure Precise Wireless Transmission Design for Multi-user UAV Broadcasting System
Authors: Shen Tong , Liu Tingting , Lin Yan , Wu Yongpeng , Shu Feng , Han Zhu 
Published: June 2020

Abstract
In this paper, two regional robust secure precise wireless transmission (SPWT) schemes for multi-user unmanned aerial vehicle (UAV): 1)regional signal-to-leakage-and-noise ratio (SLNR) and artificial-noise-to-leakage-and-noise ratio (ANLNR) (R-SLNR-ANLNR) maximization and 2) point SLNR and ANLNR (P-SLNR-ANLNR) maximization, are proposed to tackle with the estimation errors of the target users’ location. In the SPWT system, the estimation error for SPWT cannot be ignored. However the conventional robust methods in secure wireless communications optimize the beamforming vector in the desired positions only in statistical means and cannot guarantee the security for each symbol. The proposed regional robust schemes are designed for optimizing the secrecy performance in the whole error region around the estimated location. Specifically, with the known maximal estimation error, we define the target region and wiretap region. Then design an optimal beamforming vector and an artificial noise projection matrix, which achieve the confidential signal in the target area having the maximal power while only few signal power is conserved in the potential wiretap region. Instead of considering the statistical distributions of the estimated errors into optimization, we optimize the SLNR and ANLNR of the whole target area, which significantly decreases the complexity. Moreover, the proposed schemes can ensure that the desired users are located in the optimized region, which are more practical than the conventional methods. Simulation results show that our proposed regional robust SPWT design is capable of substantially improving the secrecy rate compared to the conventional non-robust method. The P-SLNR-ANLNR maximization-based method has the comparable secrecy performance with lower complexity than that of the R-SLNR-ANLNR maximization-based method.
Successful Chiropractic and Rehabilitation Prevents Spinal Fusion Surgery for Chronic Low Back Pain: A Case Report
Authors: Roloff Joel 
Published: June 2020

Abstract
A 37-year-old female presented with low back and right leg pain that increased over a year despite interventions from a Chiropractor, Physical Therapist, Orthopedist, Pain Specialist, and Neurosurgeon. The patient failed medical management, local steroid injections, physical therapy, and had a very brief period of relief following surgical discectomy. She was considering spinal fusion surgery when she sought a second opinion. She described radiating pain that extended beyond the knee into the calf and ankle area latera and anterior as “sharp” and “twisted”. Treatment began with Chiropractic adjustments and soft tissue work using post-isometric relaxation (PIR) due to the amount of pain the patient was in and progressed from twice a week to weekly intervals using both passive therapy and active rehabilitation exercises. Using the Oswestry disability index (Fairbank JC, 2000), the patient progressed from a 62% disability “(crippled)” to 36% “(moderate disability)” during five weeks of in-office treatment, to 16% “(minimal disability)” during a 5 ½ week hiatus from in office care during which she continued at home active rehabilitation exercises. The goal of this report is to detail the importance of proper assessment and incorporating both passive and active care into a treatment plan. This report shows the effectiveness of a comprehensive history that leads to patient informed goal determination, in conjunction with examination, functional assessment, with the addition of active exercise to a passive treatment plan.
LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and FKBP1A
Authors: Zhao Zhongwei , Song Jingjing , Zhang Dengke , Wu Fazong , Tu Jianfei , Xu Min , Ji Jiansong 
Published: June 2020

Abstract
Accumulating evidences has been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). snoRNA host gene 6 (SNHG6) is believed to be involved in several human cancers, but the specific molecular mechanism of SNHG6 in HCC is not well studied. Here, we found SNHG6 was highly expressed in HCC tissues. Next, using Hep3B and Huh7 cells, we confirmed knockdown of SNHG6 could reduce the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of FKBP1A was regulated through SNHG6/ miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 could dramatically reduce the tumor growth ability of Huh7 cells in vivo. Taking together, we concluded that SNHG6/miR-6509-5p/FKBP1A axis functioned in the progression of hepatocellular carcinoma, and could be the promising therapeutic targets in hepatocellular carcinoma.
Development and validation of an immune-related gene pairs signature in lower-grade glioma
Authors: Zhang Xu , Ping Shuai , Zhang Rui , Li Can , Gao Caibin , Ma Hui , Sun Tao , Wang Feng 
Published: June 2020

Abstract
Background

Lower-grade gliomas (LGG) are the prevalent primary intracerebral malignancy tumor. Increasing evidence indicated an association between immune signature and LGG prognosis. Thus, we aim to develop an immune-related gene pairs (IRGPs) signature that can predict prognosis for LGG.
Method:

Gene expression levels and clinical information of LGG patients (LGGs) were collected from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. The two databases were divided into training cohort (n = 515) and an independent validation cohort (n = 604). IGRPs significantly associated with prognosis were selected by Cox regression. Gene set enrichment analysis and filtration were performed on IGRPs.
Results

Within 1991 immune genes, an 8 IRGPs signature including 15 unique genes was constructed, which had a significant association with survival. In the validation dataset, the IRGPs signature significantly stratified LGGs into low- and high-risk groups (P < 0.001), and it remained an independent prognostic factor in univariate and multivariate analyses (P < 0.001). Additionally, 26 functional pathways were filtrated through the intersection of Gene set enrichment analysis (GSEA) and gene ontology (GO) enrichment analysis.
Conclusion

The IGRPs signature demonstrated good prognostic value in lower-grade glioma, which may provide new insights into individual treatment for glioma patients. And the IGRPs might take effect through these filtrated 26 functional pathways.
Immune gene prognostic signature for disease free survival of gastric cancer Translational research of an artificial intelligence survival predictive system
Authors: zhang zhiqiao , He Tingshan , Huang Liwen , Li Jing , Wang Peng 
Published: June 2020

Abstract
Background
The progress of artificial intelligence algorithms and massive data provide new ideas and choices for individual mortality risk prediction for cancer patients. The current research focused on depict immune gene related regulatory network and develop an artificial intelligence survival predictive system for disease free survival of gastric cancer.
Methods
Multi-task logistic regression algorithm, Cox survival regression algorithm, and Random survival forest algorithm were used to develop the artificial intelligence survival predictive system.
Results
Nineteen transcription factors and seventy immune genes were identified to construct a transcription factor regulatory network of immune genes. Multivariate Cox regression identified fourteen immune genes as prognostic markers. These immune genes were used to construct a prognostic signature for gastric cancer. Concordance indexes were 0.800, 0.809, and 0.856 for 1-, 3- and 5- year survival. An interesting artificial intelligence survival predictive system was developed based on three artificial intelligence algorithms for gastric cancer. Gastric cancer patients with high risk score have poor survival than patients with low risk score.
Conclusions
The current study constructed a transcription factor regulatory network and developed two artificial intelligence survival prediction tools for disease free survival of gastric cancer patients. These artificial intelligence survival prediction tools are helpful for individualized treatment decision.
Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome
Authors: de Almeida Luciana Yamamoto , Pereira-Martins Diego Antonio , Lima Ana Sílvia Gouvêa , Baggio Márcia Sueli , Koury Luisa Corrêa de Araujo , Lange Ana Paula , Bassi Sarah Cristina , Scheucher Priscila Santos , Rego Eduardo 
Published: June 2020

Abstract
Background
Differentiation syndrome (DS) is the main life-threatening adverse event that occurs in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA). Cytokine imbalances have been reported to play role during the developing of APL-DS. However, the relationship between the plasma cytokine levels and their prognostic value for the prediction of DS developing in APL patients during the treatment with ATRA and anthracyclines has not been previously reported.
Methods
In this study, we followed an APL cohort (n = 17) over seven days of ATRA therapy in DS (n = 6) and non-DS groups (n = 11). Interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α were measured in the peripheral blood plasma from 17 APL patients and 11 healthy adult controls by using the cytometric bead array method.
Results
In non-DS patients, IL-8 plasma levels were significantly reduced in the seventh day of ATRA treatment whereas their levels did not discriminate between DS and non-DS development. No significant differences were found in IL-6 levels between groups. Other cytokines tested were all undetectable in APL patients or healthy controls.
Conclusions
We demonstrated that the modulation of IL-8 following ATRA treatment may occur regardless of the development of DS and, therefore, does not appear to be a predictive biomarker to monitor the APL-DS.