bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elastoplastic Constitutive Modeling for Reinforced Concrete in Ordinary State-Based Peridynamics
Authors: Li Tianyi , Gu Xin , Zhang Qing , Xia Xiaozhou 
Published: October 2020

ABSTRACTA non-local, ordinary state-based, peridynamic elastoplastic model is formulated to numerically simulate the fracture of reinforced concrete materials. Several basic definitions are first discussed to avoid confusion; and then, a detailed derivation of the force vector state is presented, leading to a unified expression of force state for one-, two- and three-dimensional elasticity problems. Furthermore, an ordinary state-based peridynamic (OSB PD) elastoplastic analysis approach is developed for both plastic compressible and incompressible materials, including the constitutive relationship, the yield function, the consistency condition and the plasticity flow rule. The peridynamic predictions of a quasi-static deformation of the steel rods are in good agreement with the analytical solution. Moreover, the OSB PD plasticity is verified by analyzing a square plate with or without a central hole suffering different loading-unloading paths. Finally, a two dimensional reinforced concrete clamped beam subjected to impact loading is simulated with the proposed OSB PD elastoplasticity, demonstrating its capability in capturing the damage characteristics and structural failure behavior. Simulation results show good accuracy of the peridynamics in simulating elastoplastic problems.
Nature, Labour, and the Making of Ecological Peripheries
Authors: Ross Corey 
Published: October 2020

AbstractThis article briefly considers how the integration of the biophysical world into our analyses of the past can enhance our understanding of the socio-economic inequalities of the modern world. Taking Ulbe Bosma'sThe Making of Peripheryas its central reference point, it argues that the process of “peripheralization” – generally treated as an economic or social phenomenon – can also be usefully approached as an interaction between human and non-human forces. It uses the example of Southeast Asian rubber production to show how the different arrangements of people, plants, soil and water on European estates and indigenous smallholdings gave the latter distinct ecological advantages that boosted their oft-cited economic competitiveness, and that consequently forced plantations to extract even more value from cheap labour. In this sense, the environmental history of Southeast Asian rubber offers further evidence for Bosma's core theses about the heterogeneity of peripheralization processes and the importance of demography and labour relations in shaping them.
Polygenic prediction of PTSD trajectories in 9/11 responders
Authors: Waszczuk Monika A. , Docherty Anna R. , Shabalin Andrey A. , Miao Jiaju , Yang Xiaohua , Kuan Pei-Fen , Bromet Evelyn , Kotov Roman , Luft Benjamin J. 
Published: October 2020

AbstractBackgroundGenetics hold promise of predicting long-term post-traumatic stress disorder (PTSD) outcomes following trauma. The aim of the current study was to test whether six hypothesized polygenic risk scores (PRSs) developed to capture genetic vulnerability to psychiatric conditions prospectively predict PTSD onset, severity, and 18-year course after trauma exposure.MethodsParticipants were 1490 responders to the World Trade Center (WTC) disaster (mean age at 9/11 = 38.81 years, s.d. = 8.20; 93.5% male; 23.8% lifetime WTC-related PTSD diagnosis). Prospective longitudinal data on WTC-related PTSD symptoms were obtained from electronic medical records and modelled as PTSD trajectories using growth mixture model analysis. Independent regression models tested whether six hypothesized psychiatric PRSs (PTSD-PRS, Re-experiencing-PRS, Generalized Anxiety-PRS, Schizophrenia-PRS, Depression-PRS, and Neuroticism-PRS) are predictive of WTC-PTSD outcomes: lifetime diagnoses, average symptom severity, and 18-year symptom trajectory. All analyses were adjusted for population stratification, 9/11 exposure severity, and multiple testing.ResultsDepression-PRS predicted PTSD diagnostic status (OR 1.37, CI 1.17–1.61, adjusted p = 0.001). All PRSs, except PTSD-PRS, significantly predicted average PTSD symptoms (β = 0.06–0.10, adjusted p < 0.05). Re-experiencing-PRS, Generalized Anxiety-PRS and Schizophrenia-PRS predicted the high severity PTSD trajectory class (ORs 1.21–1.28, adjusted p < 0.05). Finally, PRSs prediction was independent of 9/11 exposure severity and jointly accounted for 3.7 times more variance in PTSD symptoms than the exposure severity.ConclusionsPsychiatric PRSs prospectively predicted WTC-related PTSD lifetime diagnosis, average symptom severity, and 18-year trajectory in responders to 9/11 disaster. Jointly, PRSs were more predictive of subsequent PTSD than the exposure severity. In the future, PRSs may help identify at-risk responders who might benefit from targeted prevention approaches.
Resolving Contradictions: Samuel Hirsch and the Stakes of Modern Jewish Thought
Authors: Erlewine Robert 
Published: October 2020

AbstractThis essay treats the contradictions that beset Samuel Hirsch'sDie Religionsphilosophie der Judenin order to clarify the nature of the study of modern Jewish thought. I begin by examining how Emil Fackenheim presents the contradiction in Hirsch's thought as evidence of the incompatible assumptions underlying dominant strands of modern philosophy and “authentic” Jewish theology. Agreeing with Fackenheim that Hirsch's work is contradictory, this essay diverges on both the nature of this contradiction and its implications for Jewish thought. I claim that the argument ofDie Religionsphilosophie der Judenfounders as a result of Hirsch's refusal to choose between three different, and ultimately incompatible, strategies for articulating the relationship between God and human beings. I then conclude by exploring the implications of the collapse of Hirsch's position with regard to the dispute between theocentrists and ethical monotheists and for the field of modern Jewish thought more broadly.
The Marquis of Anglesey: working and social relationships on a Dorset estate (c. 1812–1844)
Authors: Beardmore Carol 
Published: October 2020

AbstractThe Marquis of Anglesey on his Dorset estate was an absentee landlord who maintained close relationships with his estate through extensive correspondence with his land agent William Castleman. The surviving letters are a very rich source by which to examine the minutiae of rural life and a way to reconstruct social and working relationships within the nineteenth-century English landed estate. By focusing on a range of customary and unwritten rights, this article will consider issues such as how tenants navigated renegotiation of their leases, sought rent abatements or compensation for damage to their crops from hunting. Working and social relationships on such an estate were closely interlinked, as is widely shown here. The article also raises more contentious estate issues such as who had the rights to fallen and standing timber, the customs affecting courts, the repair of churches, and the responsibilities for building and maintaining schools. Throughout, the issue of ‘social control’ is assessed. Together the range of documented work and social interactions provide a fuller picture of the functioning of a southern English great estate in the early nineteenth century, and allow us to examine this rural community beyond the remit of its agricultural history.
Global Public Health Database Support to Population-Based Management of Pandemics and Global Public Health Crises, Part II: The Database
Authors: Burkle Frederick M. , Bradt David A. , Green Joseph , Ryan Benjamin J. 
Published: October 2020

AbstractThis two-part article examines the global public health (GPH) information system deficits emerging in the coronavirus disease 2019 (COVID-19) pandemic. It surveys past, missed opportunities for public health (PH) information system and operational improvements, examines current megatrend changes to information management, and describes a new multi-disciplinary model for population-based management (PBM) supported by a GPH Database applicable to pandemics and GPH crises.
Assessing the scale and spread of an experiential teaching kitchen in after-school programming among school-age children
Authors: Heerman William J , Elsakary Yasmeen , Sommer Evan C , Escarfuller Juan , Barkin Shari L 
Published: October 2020

AbstractObjective:To scale-out an experiential teaching kitchen in Parks and Recreation centres’ after-school programming in a large urban setting among predominantly low-income, minority children.Design:We evaluated the implementation of a skills-based, experiential teaching kitchen to gauge programme success. Effectiveness outcomes included pre–post measures of child-reported cooking self-efficacy, attitudes towards cooking, fruit and vegetable preference, intention to eat fruits and vegetables and willingness to try new fruits and vegetables. Process outcomes included attendance (i.e., intervention dose delivered), cost, fidelity and adaptations to the intervention.Setting:After-school programming in Parks and Recreation Community centres in Nashville, TN.Participants:Predominantly low-income minority children aged 6–14 years.Results:Of the twenty-five city community centres, twenty-one successfully implemented the programme, and nineteen of twenty-five implemented seven or more of the eight planned sessions. Among children with pre–post data (n 369), mean age was 8·8 (sd 1·9) years, and 53·7 % were female. All five effectiveness measures significantly improved (P < 0·001). Attendance at sessions ranged from 36·3 % of children not attending any sessions to 36·6 % of children attending at least four sessions. Across all centres, fidelity was 97·5 %. The average food cost per serving was $1·37.Conclusions:This type of nutritional education and skills building experiential teaching kitchen can be successfully implemented in a community setting with high fidelity, effectiveness and organisational alignment, while also expanding reach to low-income, underserved children.
Relationships Matter – The Impact of Working Alliances in Employment Services
Authors: Ravn Rasmus Lind , Bredgaard Thomas 
Published: October 2020

A central assumption in social policy research and practice is that a strong working alliance between caseworkers and clients produces the best outcomes. There is, however, limited empirical evidence to support this assumption. This is especially the case within Active Labour Market Policies, where existing research focuses on programme effects rather than relationship effects.In this article, we examine whether strong working alliances produce higher employment and education outcomes for disadvantaged jobseekers. The case is a Danish municipality that invested in reducing the caseloads of caseworkers working with disadvantaged social assistance recipients. The data combine survey data on social assistance recipients with outcome data from national administrative registers. Based on linear regressions, the analysis indicates that strong working alliances are positively related to subsequent employment and education outcomes. We discuss the implications, limitations and generalisability of this finding and the conditions for providing stronger working alliances in employment services.
Diversity in jackfruit (Artocarpus heterophyllus Lam.): insights into fruit characterization for the identification of superior genotypes
Authors: Dhakar M.K. , Das Bikash , Sarkar P.K. , Nath Vishal , Singh A.K. , Bhatt B.P. 
Published: October 2020

AbstractJackfruit (Artocarpus heterophyllus Lam.) is a nutritious crop from the Moraceae family. The current study was undertaken to evaluate the phenotypic diversity of fruit characteristics using a set of 27 standardized fruit descriptors to describe 28 jackfruit genotypes. These data were used to identify the superior jackfruit genotype that could be used for commercial cultivation. The data revealed a wide range of differences among the genotypes for all the traits studied. Cluster analysis classified the genotypes into four major groups that confirmed the wide diversity among them. Principal component analysis (PCA) also revealed that 80.22% of the variability among the jackfruit genotypes was explained by the first five principal components (PCs). Based on the overall results, the Indian Council of Agricultural Research, Research Complex for Eastern Region (ICAR-RCER) JS 6/3 and 10/3 genotypes were found to be the most promising for table purposes (medium fruit size, pulp percentage >50 and total soluble solid (TSS) >20°Brix), whereas the ICAR-RCER JS 7/7 genotype with large fruit size, pulp percentage >50 and TSS >20°Brix was found to be suitable for processing. The coefficient of variation was the least for traits such as TSS (12.56%) and average seed length (13.56%). Hence, priority may also be given to the TSS and seed size when exploring promising genotypes and operating a selection procedure for crop improvement in jackfruit. The information generated under the study forms a potential baseline for fruit breeders to use in selecting genotypes with superior fruit qualities for jackfruit crop improvement programmes in the future.
The Pacific Equatorial Undercurrent in Three Generations of Global Climate Models and Glider Observations
Authors: Karnauskas Kristopher B. , Jakoboski Julie , Johnston T. M. Shaun , Owens W. Brechner , Rudnick Daniel L. , Todd Robert E. 
Published: October 2020

AbstractThe Equatorial Undercurrent (EUC) is a vital component of the coupled ocean‐atmosphere system in the tropical Pacific. The details of its termination near the Galápagos Islands in the eastern Pacific have an outsized importance to regional circulation and ecosystems. Subject to diverse physical processes, the EUC is also a rigorous benchmark for global climate models (GCMs). Simulations of the EUC in three generations of GCMs are evaluated relative to recent underwater glider observations along 93°W. Simulations of the EUC have improved, but a slow bias of ~36% remains in the eastern Pacific, along with a dependence on resolution. Additionally, the westward surface current is too slow, and stratification is too strong (weak) by ~50% above (within) the EUC. These biases have implications for mixing in the equatorial cold tongue. Downstream lies the Galápagos, now resolved to varying degrees by GCMs. Properly representing the Galápagos is necessary to avoid new biases as the EUC improves.
Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
Authors: Meunier Godelieve , Birsen Rudy , Cazelles Clarisse , Belhadj Maya , Cantero-Aguilar Lilia , Kosmider Olivier , Fontenay Michaela , Azar Nabih , Mayeux Patrick , Chapuis Nicolas , Tamburini Jerôme , Bouscary Didier 
Published: October 2020

AbstractAcute myeloid leukemia (AML) is an aggressive disease with a poor prognosis. Vacuolar protein sorting 34 (VPS34) is a member of the phosphatidylinositol-3-kinase lipid kinase family that controls the canonical autophagy pathway and vesicular trafficking. Using a recently developed specific inhibitor (VPS34-IN1), we found that VPS34 inhibition induces apoptosis in AML cells but not in normal CD34+ hematopoietic cells. Complete and acute inhibition of VPS34 was required for the antileukemic activity of VPS34-IN1. This inhibitor also has pleiotropic effects against various cellular functions related to class III PI3K in AML cells that may explain their survival impairment. VPS34-IN1 inhibits basal and l-asparaginase-induced autophagy in AML cells. A synergistic cell death activity of this drug was also demonstrated. VPS34-IN1 was additionally found to impair vesicular trafficking and mTORC1 signaling. From an unbiased approach based on phosphoproteomic analysis, we identified that VPS34-IN1 specifically inhibits STAT5 phosphorylation downstream of FLT3-ITD signaling in AML. The identification of the mechanisms controlling FLT3-ITD signaling by VPS34 represents an important insight into the oncogenesis of AML and could lead to new therapeutic strategies.
Correction: NanoSIMS single cell analyses reveal the contrasting nitrogen sources for small phytoplankton
Authors: Berthelot Hugo , Duhamel Solange , L’Helguen Stéphane , Maguer Jean-Francois , Wang Seaver , Cetinić Ivona , Cassar Nicolas 
Published: October 2020

Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Melanoma recurrence patterns and management after adjuvant targeted therapy: a multicentre analysis
Authors: Bhave Prachi , Pallan Lalit , Long Georgina V. , Menzies Alexander M. , Atkinson Victoria , Cohen Justine V. , Sullivan Ryan J. , Chiarion-Sileni Vanna , Nyakas Marta , Kahler Katharina , Hauschild Axel , Plummer Ruth , Trojaniello Claudia , Ascierto Paolo A. , Zimmer Lisa , Schadendorf Dirk , Allayous Clara , Lebbe Celeste , Maurichi Andrea , Santinami Mario , Roy Severine , Robert Caroline , Lesimple Thierry , Patel Sapna , Versluis Judith M. , Blank Christian U. , Khattak Adnan , Van der Westhuizen Andre , Carlino Matteo S. , Shackleton Mark , Haydon Andrew 
Published: October 2020

Abstract
Background
Adjuvant targeted therapy (TT) improves relapse free survival in patients with resected BRAF mutant stage III melanoma. The outcomes and optimal management of patients who relapse after adjuvant TT is unknown.

Methods
Patients from twenty-one centres with recurrent melanoma after adjuvant TT were included. Disease characteristics, adjuvant therapy, recurrence, treatment at relapse and outcomes were examined.

Results
Eighty-five patients developed recurrent melanoma; nineteen (22%) during adjuvant TT. Median time to first recurrence was 18 months and median follow-up from first recurrence was 31 months. Fifty-eight (68%) patients received immunotherapy (IT) or TT as 1st line systemic therapy at either first or subsequent recurrence and had disease that was assessable for response. Response to anti-PD-1 (±trial agent), combination ipilimumab-nivolumab, TT rechallenge and ipilimumab monotherapy was 63%, 62% 25% and 10% respectively. Twenty-eight (33%) patients had died at census, all from melanoma. Two-year OS was 84% for anti-PD-1 therapy (±trial agent), 92% for combination ipilimumab and nivolumab, 49% for TT and 45% for ipilimumab monotherapy (p = 0.028).

Conclusions
Patients who relapse after adjuvant TT respond well to subsequent anti-PD-1 based therapy and have outcomes similar to those seen when first line anti-PD-1 therapy is used in stage IV melanoma.
miR-322/-503 rescues myoblast defects in myotonic dystrophy type 1 cell model by targeting CUG repeats
Authors: Shen Xiaopeng , Xu Feng , Li Meng , Wu Shen , Zhang Jingyi , Wang Ao , Xu Lei , Liu Yu , Zhu Guoping 
Published: October 2020

AbstractMyotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function in DM1, microRNAs that regulated DM1 via directly targeting the expanded CUG repeats were rarely reported. Here we discovered that miR-322/-503 rescued myoblast defects in DM1 cell model by targeting the expanded CUG repeats. First, we studied the function of miR-322/-503 in normal C2C12 myoblast cells. Downregulation of miR-322/-503 significantly hindered the myoblast differentiation, while miR-322/-503 overexpression promoted the process. Next, we examined the role of miR-322/-503 in the DM1 C2C12 cell model. miR-322/-503 was downregulated in the differentiation of DM1 C2C12 cells. When we introduced ectopic miR-322/-503 expression into DM1 C2C12 cells, myoblast defects were almost fully rescued, marked by significant improvements of myoblast differentiation and repressions of ribonuclear foci formation and aberrant alternative splicing. Then we investigated the downstream mechanism of miR-322/-503 in DM1. Agreeing with our previous work, Celf1 was proven to be miR-322/-503′s target. Celf1 knockdown partially reproduced miR-322/-503′s function in rescuing DM1 C2C12 differentiation but was unable to repress ribonuclear foci, suggesting other targets of miR-322/-503 existed in the DM1 C2C12 cells. As the seed regions of miR-322 and miR-503 were complementary to the CUG repeats, we hypothesized that the CUG repeats were the target of miR-322/-503. Through expression tests, reporter assays, and colocalization staining, miR-322/-503 was proved to directly and specifically target the expanded CUG repeats in the DM1 cell model rather than the shorter ones in normal cells. Those results implied a potential therapeutic function of miR-322/-503 on DM1, which needed further investigations in the future.
Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43
Authors: Watanabe Seiji , Inami Hidekazu , Oiwa Kotaro , Murata Yuri , Sakai Shohei , Komine Okiru , Sobue Akira , Iguchi Yohei , Katsuno Masahisa , Yamanaka Koji 
Published: October 2020

AbstractCytoplasmic inclusion of TAR DNA-binding protein 43 (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and a subtype of frontotemporal lobar degeneration (FTLD). Recent studies have suggested that the formation of cytoplasmic TDP-43 aggregates is dependent on a liquid–liquid phase separation (LLPS) mechanism. However, it is unclear whether TDP-43 pathology is induced through a single intracellular mechanism such as LLPS. To identify intracellular mechanisms responsible for TDP-43 aggregation, we established a TDP-43 aggregation screening system using a cultured neuronal cell line stably expressing EGFP-fused TDP-43 and a mammalian expression library of the inherited ALS/FTLD causative genes, and performed a screening. We found that microtubule-related proteins (MRPs) and RNA-binding proteins (RBPs) co-aggregated with TDP-43. MRPs and RBPs sequestered TDP-43 into the cytoplasmic aggregates through distinct mechanisms, such as microtubules and LLPS, respectively. The MRPs-induced TDP-43 aggregates were co-localized with aggresomal markers and dependent on histone deacetylase 6 (HDAC6), suggesting that aggresome formation induced the co-aggregation. However, the MRPs-induced aggregates were not affected by 1,6-hexanediol, an LLPS inhibitor. On the other hand, the RBPs-induced TDP-43 aggregates were sensitive to 1,6-hexanediol, but not dependent on microtubules or HDAC6. In sporadic ALS patients, approximately half of skein-like TDP-43 inclusions were co-localized with HDAC6, but round and granular type inclusion were not. Moreover, HDAC6-positive and HDAC6-negative inclusions were found in the same ALS patient, suggesting that the two distinct pathways are both involved in TDP-43 pathology. Our findings suggest that at least two distinct pathways (i.e., aggresome formation and LLPS) are involved in inducing the TDP-43 pathologies.