bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Observing patterns in MRI with QSM in Patients with SOD1 and C9ORF72 Genetic ALS
Authors: Warner DO Robin 
Published: September 2020

Abstract

Introduction: The most common forms of familial ALS are due to the C9ORF72 and SOD1 genes. Pathology studies have demonstrated patients with C9ORF72 ALS tend to develop more protein aggregates in the cerebellum and temporal lobes, while SOD1 patients develop more protein aggregates in the frontal and temporal lobes. (REF). Other means of looking for these signs are not established. Currently, we use brain MRI quantitative susceptibility mapping analysis (QSM) to examine susceptibility in the motor cortex, which is typically increased in motor neuron disease, correlating with the clinical syndrome. We designed a study to retrospectively assess the MRI/QSM in genetic ALS patients for specific regional changes.Methods: We retrospectively reviewed all genetic ALS patients seen in Neurology at Hospital for Special Surgery from 2013 through 2018 who had MRI with QSM. Our neuroradiologist carefully examined the scans of each patient.Results: We found no distinguishing abnormalities in the brain MRIs of the genetic ALS patients reviewed. QSM of the motor cortices and corticospinal tracts showed increase in susceptibility, which is not unique to any specific type of ALS.Discussion: MRI/QSM may not be useful in distinguishing ALS patients with the C9ORF72 or SOD1 mutations. This could reflect that the amount of protein aggregation may not be directly related to axonal loss, or that they affect certain neurons/tracts more than others.
SILÍCIO FOLIAR EM DIFERENTES CULTIVARES DE TRIGO
Authors: Martin Thomas Newton , Leivas Stecca Jessica Deolinda , Deak Evandro Ademir , Brunnig Lucas Allan , Gardin Alessio Pedro 
Published: September 2020

A nutrição vegetal é importante para o crescimento e desenvolvimento das plantas. Aliado a isso, para obtenção de produtividades elevadas é necessário que não existam restrições bióticas e abióticas que afetem os componentes de rendimento das culturas. O silício embora não reconhecido como elemento essencial, é benéfico às plantas. Objetivou-se avaliar as alterações provocadas na estatura das plantas, na massa de hectolítro e nos componentes de produtividade da cultura do trigo pela aplicação foliar de silício. Os tratamentos foram distribuídos em um modelo bifatorial (15 x 2), em delineamento blocos ao acaso com quatro repetições, sendo o primeiro fator constituído por 15 cultivares de trigo (Sinuelo, TEC Frontale, Ametista, BRS 331, Quartzo, Mestre, Toruk, TEC 10, DNA Oro, Sintonia, Iguaçu, Prisma, Parrudo, TEC 6219, BRS 327) e o segundo por aplicação ou não de silício. As variáveis avaliadas foram número de plantas, estatura de plantas, número de espigas, produtividade de grãos, massa de mil grãos e massa de hectolitro. Os componentes de produtividade não foram alterados pela aplicação foliar de silício. A massa de hectolítro de algumas cultivares apresentaram acréscimos devido ao fornecimento de silício. As demais diferenças observadas são atribuídas às variações entre as cultivares de trigo.
Optimization of ventilated brake disc rotor geometry for enhanced structural characteristics
Authors: Roy Indira , A Bharatish 
Published: September 2020

This paper focuses on analyzing the effect of geometrical parameters on structural performance of the ventilated brake disc. Multi-objective optimization through response surface methodology was deployed for improving the structural performance of ventilated brake discs. Simulation runs were designed based on central composite design technique. The second order regression models correlating the geometry parameters with maximum deformation and equivalent stress were developed. ANOVA was performed to test the significance of disc geometry parameters. The deformation and equivalent stress were influenced by flange outer peripheral radius. While the spigot radius had a significant effect on the deformation but not on equivalent stress. Also, the mounting surface radius influenced the equivalent stress developed on the ventilated brake disc rotor. The multi-objective optimization of geometrical characteristics for minimum deformation (4.2332 µm) and minimum equivalent stress (4.00989 MPa) yielded significant reduction in total deformation and equivalent stress i.e., 10.28 % and 9.12 % respectively at optimal levels of geometrical parameters.
A fractional Maxwell approach for the shock response of viscoelastic oscillator
Authors: Qin Yuan , Sun Dagang , Li Zhanlong , Wang Yao , Chang Chao , Sun Bao 
Published: September 2020

Viscoelastic damping structures under shock loading with variable amplitude and frequency are always in the multifactorial dynamic state, of which the shock response is obviously different from that under low strain rate. In order to accurately describe the impact mechanical properties of viscoelastic damped materials, a fractional order Maxwell model (FMM) is constructed. To verify the adopted model, the dynamic experiments for different strain rates (1800 s-1, 2500 s-1, 3500 s-1 and 4000 s-1) are performed by SHPB system. The experimental stress-strain curves should be divided into three stages: the linear stage, the strain-softening stage and the strain-hardening stage. As increase with the strain rate, the peak strain, the peak stress and the curvature of the curve in strain-softening stage increase, and the hardening effect in the strain-hardening stage tends to stronger, demonstrating a distinct strain rate effect in viscoelastic damped materials. The reason is that as increase of the strain rate, the action time of external loading gets closer to the relaxation time of the molecular chain segment, indicating the apparent strain rate-dependence of molecular slip and friction. The comparisons are made between the models of FMM, fractional Kelvin-Voight, ZWT and Ogden considering the strain rate-dependent. As a fractional-order model, FMM model has the minimum mean of RMSE 0.460 among the four models. The results indicate that FMM model could accurately describe the impact mechanical behavior characteristics of viscoelastic materials in a wider range of strain rate with comprehensive superiority of higher fitting precision, fewer parameters and clear physical meaning.
Substituting wheat flour with okara flour in biscuit production
Authors: Momin Md. A. , Jubayer Md. F. , Begum Anjuman A. , Nupur Asmaul H. , Ranganathan Thottiam V. , Mazumder Md. A. R. 
Published: September 2020

Introduction. High fiber bakery products can be a healthy snack option for consumers. Our study focused on the effect of replacing wheat flour with okara flour on the physicochemical, nutritional, textural, and sensory attributes of biscuits.
Study objects and methods. We used 2, 4, 6, and 8% w/w okara flour to prepare biscuits. Refined wheat flour (control), mixed flour (okara and wheat flour), dough, and biscuits were assessed for physicochemical, textural, and nutritional properties, as well as sensory characteristics. The volume of particles was higher in 8% okara flour (145 μm) compared to refined wheat flour (91 μm).
Results and discussion. 2, 4, 6, and 8% w/w okara flour biscuits showed significantly (P ≤ 0.05) lower spread ratio and weight loss than biscuits from wheat flour. Hardness, stickiness, and cohesiveness of 2, 4, 6, and 8% okara flour dough were significantly (P ≤ 0.05) lower compared to the control, resulting in decreased cutting strength and increased hardness of okara flour biscuits. Moisture, protein, ash, fat, and crude fiber contents of 2, 4, 6, and 8% okara biscuits were significantly (P ≤ 0.05) higher compared to the control biscuits. The sensory evaluation suggested that 4% okara biscuits had higher consumer acceptability and were superior to the control and other okara biscuits.
Conclusion. Mixed flour biscuits made from okara and wheat flours were superior in physicochemical, nutritional, textural, and sensory attributes, which allows considering them as an alternative healthy snack.
Use of extension variance in monitoring of fluoride in bottled water
Authors: Luiz T. S. J. , Souza V. C. G. , Koppe J. C. 
Published: September 2020

AbstractTemporal variograms allowed the analyzing of the temporal variance of eight sources of mineral waters during the four climatic seasons. The water sources are located in the state of São Paulo, Brazil. The extension variance compares the temporal variance obtained in the collection interval t with the temporal variance obtained in the collection interval T (where T is twice as large as t). Based on the calculation of the extension variance, relative sampling errors for the confidence intervals (CI) equal to 68% and 99% were obtained. For the sampled sources, the greater the sampling interval, the greater the values obtained for the extension variance and for the relative sampling error. The greater the confidence interval analyzed, the greater the relative sampling error to be obtained. The results showed a very high global sampling error for collection intervals greater than 32 days (relative error greater than 10%) when the confidence interval was CI = 68%. When the confidence interval was 99.9%, for collection intervals greater than two days, relative sampling errors greater than 10% have already been obtained. It was concluded that for the fluoride parameter the sampling time should not be longer than two days.
Artificial Intelligence Chatbot for Depression: Descriptive Study of Usage
Authors: Dosovitsky Gilly , Pineda Blanca S , Jacobson Nicholas C , Chang Cyrus , Escoredo Milagros , Bunge Eduardo L 
Published: September 2020

Background
Chatbots could be a scalable solution that provides an interactive means of engaging users in behavioral health interventions driven by artificial intelligence. Although some chatbots have shown promising early efficacy results, there is limited information about how people use these chatbots. Understanding the usage patterns of chatbots for depression represents a crucial step toward improving chatbot design and providing information about the strengths and limitations of the chatbots.

Objective
This study aims to understand how users engage and are redirected through a chatbot for depression (Tess) to provide design recommendations.

Methods
Interactions of 354 users with the Tess depression modules were analyzed to understand chatbot usage across and within modules. Descriptive statistics were used to analyze participant flow through each depression module, including characters per message, completion rate, and time spent per module. Slide plots were also used to analyze the flow across and within modules.

Results
Users sent a total of 6220 messages, with a total of 86,298 characters, and, on average, they engaged with Tess depression modules for 46 days. There was large heterogeneity in user engagement across different modules, which appeared to be affected by the length, complexity, content, and style of questions within the modules and the routing between modules.

Conclusions
Overall, participants engaged with Tess; however, there was a heterogeneous usage pattern because of varying module designs. Major implications for future chatbot design and evaluation are discussed in the paper.
Reducing Alcohol and Opioid Use Among Youth in Rural Counties: An Innovative Training Protocol for Primary Health Care Providers and School Personnel
Authors: Francis Erica , Shifler Bowers Kara , Buchberger Glenn , Ryan Sheryl , Milchak William , Kraschnewski Jennifer 
Published: September 2020

Background
Given that youth alcohol use is more common in rural communities, such communities can play a key role in preventing alcohol use among adolescents. Guidelines recommend primary care providers incorporate screening, brief intervention, and referral to treatment (SBIRT) into routine care.

Objective
The aim is to train primary care providers and school nurses within a rural 10-county catchment area in Pennsylvania to use SBIRT and facilitate collaboration with community organizations to better coordinate substance use prevention efforts.

Methods
To build capacity to address underage drinking and opioid use among youth aged 9-20 years, this project uses telehealth, specifically Project ECHO (Extension for Community Healthcare Outcomes), to train primary care providers and school nurses to address substance use with SBIRT. Our project will provide 120 primary care providers and allied health professionals as well as 20 school nurses with SBIRT training. Community-based providers will participate in weekly virtual ECHO sessions with a multidisciplinary team from Penn State College of Medicine that will provide SBIRT training and facilitate case discussions among participants.

Results
To date, we have launched one SBIRT ECHO project with school personnel, enrolling 34 participants. ECHO participants are from both rural (n=17) and urban (n=17) counties and include school nurses (n=15), school counselors (n=8), teachers (n=5), administrators (n=3), and social workers (n=3). Before the study began, only 2/13 (15.5%) of schools were screening for alcohol use.

Conclusions
This project teaches primary care clinics and schools to use SBIRT to prevent the onset and reduce the progression of substance use disorders, reduce problems associated with substance use disorders, and strengthen communities’ prevention capacity. Ours is an innovative model to improve rural adolescent health by reducing alcohol and opioid use.

International Registered Report Identifier (IRRID)
DERR1-10.2196/21015
Prediabetes Screening with American Diabetes Association (ADA) Scoring in the Primary Health Care Yogyakarta (Development And Validation Of Scoring Systems)
Authors: Jeem Yaltafit Abror , Koesnanto Hari , Ikhsan Muhammad Robikhul 
Published: September 2020

Background: Numerous studies have shown the increasing of prediabetes incidence from the time being. Some of the prediabetes screening methods that can be performed at primary health care were American Diabetes Association (ADA) scoring for prediabetes. However, there was no data that describes the validity and applicability of the ADA scoring on prediabetes patients in Indonesia. Objective: To discribe prediabetes screening and to find out the applicability of the ADA scoring method in Yogyakarta primary health care. Method: The diagnostic test by scoring system of the ADA questionnaire was compared with OGTT (oral glucose tolerance test) as the gold standard. The subjects were patients of primary health care in Yogyakarta who fulfill the inclusion and exclusion criteria. Result: The subjects were 279 respondents with 227 female (81.4%) and 52 male patients (18.6%). The mean age of the study subjects was 50.4 years (SD 12.81). The sensitivity and specificity of the scoring method of ADA was 61% and 71%. This could be influenced by the difference in BMI standard as one of the scoring items. Conclusion: Prediabetes prevalence was 11.1% in the study population. The sensitivity and specificity of the scoring method of ADA is 61% and 71%. The scoring method of ADA could not be used in primary health care.
El mal de playa. Intoxicación del ganado bovino con Lantana camara
Authors: De Aluja Aline S. , Sanz Roberto , Espinosa Francisco 
Published: September 2020

Artículo originalmente publicado en:De Aluja AS, Sanz R, Espinosa F. El Mal de Playa. Intoxicación del ganado bovino con Lantana camara. VetMéx. 1970;1(4):7–12.- - - - -
Se hace un estudio clínico y de laboratorio de los animales afectados por una entidad patológica conocida desde hace muchos años con el nombre de Mal de Playa, en una zona limitada de la costa del estado de Veracruz.

Se establece que en los potreros donde ocurre la enfermedad prevalece la planta Lantana camara, conocida como hepatotóxica.
Por medio de la administración experimental de la planta a dos becerros, se produce la enfermedad con manifestaciones idénticas a las observadas en los casos de campo.
Se revisa la bibliografía al respecto y se discuten algunos puntos especiales referentes a la presentación de la enfermedad en la zona afectada.
Se concluye que el Mal de Playa es causado por la ingestión de la planta Lantana camara.
PERSPEKTIF HUKUM ISLAM TERHADAP EFEKTIFITAS PELAKSANAAN RESTORATIVE JUSTICE PADA ANAK BERHADAPAN DENGAN HUKUM
Authors: Mukdin Khairani , Heryanti Novi 
Published: September 2020

ABSTRAK ABH adalah anak yang berkonflik dengan hukum. di wilayah provinsi Aceh kasus ABH menunjukkan angka yang relatif terus naik pada tiga tahun tarkhir untuk mengantisipasi tingginya ABH hal tersebut, Indonesia telah mempunyai Undang-Undang Nomor 11 Tahun 2012 tentang Sistim Peradilan Pidana Anak yang subtansiya adalah mengenai restorative justice dan diversi untuk menghindari dan menjauhkan anak dari proses peradilan. Namun kebijakan tersebut tidak berpengaruh signifikan bagi menurunya kasus ABH.Metode penelitian ini adalah deskriptif analitis, untuk menemukan proses restorative justice dan diversi yang dilakukan oleh aparat penegak hukum dalam perkara anak berhadapan hukum (ABH) dan melihat efektivitas Undang-undang Nomor 11 Tahun 2012 serta melihat tinjauan hukum Islam terhadap pelaksanaan restorative justice dan diversi serta efektifitasnya dalam menyelesaikan perkara anak berhadapa hukum (ABH) di wilayah provinsi Aceh.Sedangkan hasil penelitiannya adalah proses restoratif justice dan diversi dalam menangani kasus ABH di Polres Kabupaten/Kota Provinsi Aceh merujuk Undang-undang Nomor 11 Tahun 2012 dan melibatkan lembaga-lembaga masyarakat lain seperti PEKSOS, BAPAS Aceh, keluarga korban dan pelaku serta perangkat Desa dengan jalan musyawarah. Efektivitas Undang-undang Nomor 11 Tahun 2012 dalam menyelesaikan perkara anak berhadapa hukum (ABH) di wilayah provinsi Aceh pada Polres Lhoksemawe, Polres Aceh Tengah, Polres Aceh Bara dan Polres Aceh Selatan dianggap telah efektif. Namun ada beberapa kendala dan hambatan. Sedangkan dalam hukum Islam sangat menekankan penyelesaian perkara pidana di luar mekanisme peradilan, juga dapat ditelusuri dari berbagai konsep dalam Al Qur’am yakni konsep islah (perdamaian). Kata Kunci: Efektivitas, restorative justice diversi, ABH, Provinsi Aceh
Inter-individual Variability in Psychological Outcomes of Supervised Exercise in Adults with Type 2 Diabetes / Variabilidad interindividual en los efectos psicológicos del ejercicio supervisado en adultos con diabetes tipo 2
Authors: Guicciardi Marco , Lecis Romina , Massidda Davide , Corgiolu Lucina , Porru Adelina , Pusceddu Matteo , Spanu Francesca 
Published: September 2020

Abstract:Exercise is a key component in the management of Type 2 Diabetes Mellitus (T2DM), however despite the strong evidence of its protective effects, a majority of the population with this diagnosis remains inactive and those who start an exercise program are not willing to train themselves over the long-term. Self-efficacy and perceived stress are related to barriers to exercise in T2DM, therefore the aim of this longitudinal study is to investigate variations across time and individual differences in both variables as effects of a supervised exercise training (6 months) in a small sample of persons diagnosed with T2DM. Results show a general decline in the mean values of self-efficacy and perceived stress at 6 months and a high individual variability in both variables. These results support the need to develop customized programs of exercise in T2DM that take into account different phases of the exercise process and individual variability. Resumen:El ejercicio es un componente clave en la prevención y el tratamiento de Diabetes Mellitus Tipo 2 (DMT2); sin embargo, a pesar de la fuerte evidencia de sus efectos protectores, la mayoría de las personas con este diagnóstico permanece inactiva y aquellos que comienzan un programa de ejercicio no están dispuestos a entrenar a largo plazo. La autoeficacia y la percepción de estrés se relacionan con las barreras para realizar ejercicio en pacientes T2DM; por lo tanto, el objetivo de este estudio longitudinal consiste en investigar las variaciones a través del tiempo y las diferencias individuales en ambas variables, como efectos de un entrenamiento de ejercicio supervisado (6 meses), en una muestra pequeña de pacientes diagnosticados con TD2M. Los resultados muestran una disminución general de los valores promedio de la autoeficacia y del estrés percibido a los 6 meses y una alta variabilidad individual en ambas variables. Estos resultados apoyan la necesidad de desarrollar programas personalizados de ejercicio en pacientes T2DM con el objetivo de considerar las diferentes fases del proceso de ejercicio y de la variabilidad individual.
Formación universitaria e intervención social: una contribución de las técnicas gestálticas / University Education and Social Intervention: A Contribution from Gestalt Techniques
Authors: Manzanera-Ruiz Roser , Sierra-Luque Francisco , Borrego-García Purificación 
Published: September 2020

Resumen:El Espacio Europeo de Educación Superior hace hincapié en la adquisición de competencias durante los procesos de enseñanza-aprendizaje. Ello supone la renovación de las metodologías didácticas tradicionales hacia otras más creativas y prácticas, que enfaticen los aspectos formativos en el saber hacer e incluyan también la dimensión emocional y psicológica de las personas. El objetivo de este artículo es mostrar cómo las técnicas de la psicoterapia Gestalt, basadas en experiencias vivenciales, permiten la adquisición de un saber hacer fundamental en los quehaceres de los profesionales de la intervención social, a través de una experiencia en el aula con estudiantes de grado de trabajo social. Mostraremos cómo el aprendizaje de estas técnicas, desde la práctica vivencial, favorece la formación de futuros profesionales y también las potencialidades y las capacidades personales y emocionales. Abstract:he European Higher Education Area emphasizes acquisition of skills in the teaching-learning process. This involves the renovation of traditional teaching methods towards other more creative aspects of learning that emphasize the “know-how” and take into consideration the individual’s emotional and psychological dimensions. The aim of this paper is to show how Gestalt psychotherapy techniques based on life experiences, allow acquisition of know-how in key tasks for social intervention professionals, through an in-class experience with social work students. We show how learning these techniques from experiential practice favours the formation of future professionals and their personal and emotional potentials and capabilities.