bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Nursing Students' Attitude Toward Nursing Process Software
Authors: Parvan Kobra , Hosseini Fahimeh Alsadat , Jasemi Madineh , Thomson Brian , Bagherian Samaneh 
Published: July 2020

Abstract
Background: The nursing process is the core and the standard of practice in nursing profession. Nowadays, the use of information technology in the field of nursing processes, education and practice has been emphasized. Since nurse’s attitudes towards clinical information systems are considered as an indicator of the success rate of information systems, and nurse’s attitudes about the nursing process can effect their execution of the process. So the purpose of this study was to evaluate nursing students' attitudes in the field of the nursing process software.Methods: In this quasi-experimental study, 160 undergraduate nursing students (terms 4-8) in Tabriz University of Medical Sciences were selected by convenience sampling. To evaluate the effectiveness of nursing process software in this study, Mazlom and rajabpoor (2014) questionnaire consisted of 21 components based on a five-point Likert scale was completed by students after using the software. Data were then analyzed by SPSS 19 software.Results: The mean score of students' attitude toward nursing process software was good (80.70 ± 5.58). The highest student satisfaction with the software was respectively in the fields of "Effectiveness of software in prioritizing patient care and problems", "Completeness of electronic patient information compared to handwritten mode" and "Software effectiveness in saving your time". Also, the lowest level of students' satisfaction with the software was respectively related to the "sense of fairness in the work-division based on the software", "the effectiveness of the software in determining your workload" and "the sense of satisfaction in the work-division based on the software". There was a statistically significant relationship between gender and age and students' attitude toward nursing process software.Conclusions: Nursing students had a positive attitude about nursing process software. Therefore, in order to make the most use of the nursing process it is recommended to use this software in educational, research and clinical fields, which require a substructure of the nursing process software in universities and clinics.
Comparison of the effectiveness of existential, cognitive-existential, and humanistic-existential group psychotherapy on psychosomatic complaints in women with type 2 diabetes mellitus
Authors: Hanis Ghaffar Nasiri , Sadeghi Masoud , Gholamrezaei Simin 
Published: July 2020

Abstract
Background and aims: A significant amount of previous studies has confirmed the positive effect of existential, cognitive-existential, and humanistic-existential interventions on psychosocial problems with different populations. However, research on the effectiveness and comparison of the effect of these three independent variables on the problem of patients with type 2 diabetes mellitus is novel. So, the purpose of this research is to study the comparison of the effectiveness of existential, cognitive-existential, and humanistic-existential group psychotherapy on psychosomatic complaints among women with type 2 diabetes mellitus.Methods: The method of the research was semi-experimental, and its experimental design includes the pretest, post-test, and two-month follow-up tests with experimental and control parallel groups. Cases of this study included women with type 2 diabetes mellitus referring to the Specialist Diabetes Clinic of Tohid Hospital in Sanandaj in the first three months of 2019. 32 subjects selected by simple random sampling method of this society and were assigned to three experimental and one control group by substituting random method. The data collected based on the scale of psychosomatic complaints Takata & Sakata (2004). After the pre-test, the experimental groups participated in 120-minute sessions for 9 weeks. Data analyzed by the statistical test of repeated measures of the General Linear Model. Results: The results of repeated measures analysis showed that the effect of the interventions in experimental groups of psychosomatic complaints was significant and stable compared to the control group (computed using alpha = 0, 05). The effect of the group humanistic-existential psychotherapy on reducing psychosomatic complaints about women with type 2 diabetes mellitus is stable and significant compared to existential and cognitive-existential psychotherapy (The mean difference is significant at the 0,05 level).Conclusion: The findings show applying humanistic-existential psychotherapy more benefits than the other two method. So, humanistic-existential group psychotherapy could be a selective therapy for reducing psychosomatic complaints about women with type 2 diabetes mellitus.
Brown and beige adipose tissue regulate systemic metabolism to resist diet-induced obesity through metabolite signals in an inter-organ signaling axis
Authors: Whitehead Anna , Krause Fynn , Moran Amy , Scragg Jason , McNally Ben , Boateng Edward , Murfitt Steven , Virtue Sam , Wright John , MacCannell Amanda , Garnham Jack , Davies Graeme , Dodgson James , Schneider Jurgen , Murray Andrew , Church Christopher , Vidal-Puig Antonio , Witte Klaus , Griffin Julian , Roberts Lee 
Published: July 2020

Abstract
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an inter-organ signaling network. Using a metabolomic approach we identified 3-methyl-2-oxovaleric acid (MOVA), 5-oxoproline (5OP), and β-hydroxyisobutyric acid (BHIBA) as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters. MOVA, 5OP and BHIBA induce a brown adipocyte-specific phenotype in white adipocytes and mitochondrial oxidative energy metabolism in skeletal myocytes both in vitro and in vivo. MOVA and 5OP signal through cAMP-PKA-p38 MAPK and BHIBA via mTOR. These metabolites reduce adiposity, increase energy expenditure and improve glucose and insulin homeostasis in mouse models of obesity and diabetes. In humans, plasma and adipose tissue MOVA, 5OP and BHIBA concentrations are correlated with markers of adipose browning and inversely associated with BMI. Our findings identify beige adipose-brown adipose-muscle physiological metabokine crosstalk.
A Novel Patient-Specific Three-Dimensional Printing Template Based on External Fixation for Pelvic Screw Insertion
Authors: Zhou Kaihua , Tao Xingguang , Pan Fugen , Luo Congfeng , Yang Huilin 
Published: July 2020

Abstract
(1) Background: To investigate the clinical effect of the novel patient-specific 3D printing templates based on external fixation for pelvic screw insertion. (2) Methods: We retrospectively studied 8 patients with pelvic fractures who were treated using this novel template from July 2017 to July 2018. During the operation, the screws were inserted with the aid of the template. The operative time per screw, radiation exposure time, and accuracy of the screw insertions as evaluated by post-operative CT scans were analyzed statistically and compared with previous outcomes using the fluoro-navigation technique. (3) Results: In the template group, a total of 9 pubis screws and 6 sacroiliac screws were inserted. The mean surgical time was 11.3 min/screw and the mean X-ray exposure time was 11.8 ± 3.9 s/screw. The mean deviation distance and angle between the actual and planned screw position was 2.6 ± 0.2 mm and 2.0 ± 0.3 degrees, and blood loss during the surgery was 12.2 ml/screw. No superficial and deep infections and no patient sustained recognized neurologic, vascular, or urologic injury occurred in the template group. The surgical time and X-ray exposure time was less than that in the fluoro-navigation group((P < 0.05) (4) Conclusions: The patient-specific template based on external fixation can guide the insertion of the pelvic screw accurately, safely and invasively and significantly reduce operation and radiation exposure time.
WITHDRAWN: Performance Modelling of the Regenerative Blower for Air Supply of SOFC System with Random Forest and Bayesian Optimization
Authors: Zhao Jiarong , Wu Xin , Xiong Xingyu , Qian Xiangchen 
Published: July 2020

Abstract
Air starvation is a serious hazard during the operation of a solid oxide fuel cell (SOFC) system. So, an accurate performance model of the air supply system is needed for the control of air flow rate and the reduction of air starvation. The performance modelling of a regenerative blower, which is used for the air supply of a 5 kW SOFC system during power generation, is proposed based on the methods of random forest (RF) and Bayesian Optimization (BO). The performance model is first built through the RF method. The BO algorithm is then used to adjust the hyper-parameters of the model. The developed model can predict the outlet air flow rate through the operation data of regenerative blower, i.e. the rotation speed of impeller, the inlet and outlet pressure, humidity and temperature, without specific geometrical parameters. A series of operation data obtained from an experimental test rig are adopted to train and validate the presented method. Finally, the prediction performance of the developed algorithm is compared with different machine learning methods, such as decision tree regression, deep neural network. Results show that the proposed method can predict the outlet air flow rate under different working conditions with minimum prediction errors within 3.5% and acceptable computational cost. Therefore, the developed algorithm is promising for performance modelling of the blower, which can be used to predict the outlet flow rate and control the air supply system at SOFC in our next research.
Endocapillary Proliferation was Associated with Unfavorable Outcomes in Children with Henoch-Schönlein Purpura Nephritis and IgA Nephropathy
Authors: Chanvitan Supatjaree , Tangnararatchakit Kanchana , Saisawat Pawaree , Chantarogh Songkiat , Worawichawong Suchin , Pirojsakul Kwanchai 
Published: July 2020

Abstract
Introduction: There are limited data on the outcomes in children with Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) in limited-resource countries. This study was aimed to evaluate the outcome of HSPN and IgAN and to evaluate the pathological findings associated with unfavorable outcomes.Materials and methods: This was a retrospective study conducted in children (≤18 years) diagnosed with HSPN or IgAN, had estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 and underwent renal biopsy between year 2002 - 2018 at Ramathibodi Hospital, Bangkok, Thailand. Clinical outcomes were graded according to the outcome classification by Counahan, as follows: favorable [A, normal; B, minor urinary abnormalities (proteinuria < 1 g/1.73 m2/day)]; unfavorable [C, active renal disease (proteinuria > 1 g/1.73 m2/day and/or hypertension); D, renal insufficiency (eGFR < 60 mL/min/1.73 m2 or died)]. Pathologies were graded according to Oxford classification.Results: A total of 47 patients (28 HSPN and 19 IgAN) were included with means of age at 9.4 ± 2.8 vs 11.3 ± 4.3 years, respectively. After a median follow-up time of 50 months, proportions of favorable outcomes in the patients with HSPN and IgAN were 82.1% (23/28) and 89.5% (17/19), respectively (p-value = 0.685). In multivariate analysis, only endocapillary proliferation (E) was associated with unfavorable outcomes in both diseases with the odds ratio (95% CI) of 12.46 (1.36 - 114.51, p-value = 0.026).Conclusion: The clinical outcomes of most patients with HSPN and IgAN were favorable and comparable. Endocapillary proliferation (E) was the only factor associated with poor outcome in both diseases.
Investigation on the influencing factors of mental health of healthcare workers for aid in Hubei during the outbreak of the COVID-19
Authors: Zhou Peng , Du Na , Diao Dongmei , OuYang Yingjie , Pathiranage Heshan Sameera Kankanam 
Published: July 2020

Abstract
Background
The objective of this study is to understand the psychological health status and analyze the related factors of healthcare workers for aid in Hubei during the epidemic. 220 subjects were investigated by Self-Rating Scale of Sleep(SRSS), Generalized Anxiety Scale (GAD-7), and 9-item patient health questionnaire (PHQ-9).
Results
The average SRSS score of all subjects was significantly higher than the national norm (p < 0.001)and the influencing factors were gender, whether the patients died under the charge of nursing/treatment, the history of psychosis and whether their family members were infected with the COVID-19. The average GAD-7 score of all subjects was in a moderate anxiety level, and the main influencing factors were gender, years of work, history of psychosis, self-perceived health statues and whether their family members were infected with the COVID-19. The average PHQ-9 score of all subjects was in mild depression level. The primary influencing factors were whether they nursed/treated severely ill patients during aid in Hubei and whether they had a history of psychosis.
Conclusions
During the outbreak of COVID-19, the symptoms of insomnia and anxiety of the healthcare workers for aid in Hubei were prominent. Moreover, male workers, those whose patients have died during their treatment, with previous anxiety disorders and whose family members infected with COVID-19 were facing more serious problems. Therefore, this special group needs to be strengthened follow-up psychological support individually.
Risk Factors for Urinary Tract Infection (UTI) Among Home Health Care Patients: Analysis Using Routinely Collected Clinical Data
Authors: Woo Kyungmi , Song Jiyoun , McDonald Margaret V. , Topaz Maxim , Shang Jingjing 
Published: July 2020

Abstract
Background: Urinary tract infection (UTI) is a complication often experienced during a home health care (HHC) episode, yet related hospitalization risk factors are unclear. Objectives: This study use multiple data sources to identify risk factors for UTI related hospitalization or emergency department (ED) visits among HHC patients.Method: We performed a multivariable logistic regression to identify risk factors for UTI-related hospitalization or ED visits using merged data from the Outcome and Assessment Information Set, electronic health record from a large HHC agency, and Center for Medicare and Medicaid claims. Results: Of 48,336 cases, 1,689 patients (3.5%) had a UTI-related hospitalization/ED visits. Being a female (OR = 1.31; 95% CI: 1.16–1.46), the presence of a urinary catheter (OR = 5.7; 95% CI: 4.54–7.14), treatment with general antibacterial and antiseptics (OR = 2.75; 95% CI: 1.02–7.38), dependency in instrumental activities of daily living (e.g., meal preparation [OR=1.72; 95% CI: 1.25-2.37]), and no available caregivers (OR = 1.79; 95% CI: 1.2–2.68) increased the odds of a UTI related event among HHC patients. Discussion/conclusion: We identified notable risk factors for UTI related hospitalization/ER visit, filling a knowledge gap on the currently understudied HHC population. Risk factors identified in this study can be used to proactively identify HHC patients at risk for UTI related hospitalization and target them for preventive interventions. Further research is needed in HHC to develop tailored interventions for at-risk patients.
A Clinical Prediction Model for Complicated Appendicitis in Children Younger than Five Years of Age
Authors: Feng Wei , Zhao Xu-Feng , Li Miao-Miao , Cui Hua-Lei 
Published: July 2020

Abstract
Background: No reliably specific method for complicated appendicitis has been identified in children younger than five years of age. This study aimed to analyze the independent factors for complicated appendicitis in children younger than five years of age, develop and validate a prediction model for the differentiation of simple and complicated appendicitis.Methods: A retrospective study of 382 children younger than five years of age with acute appendicitis from January 2007 to December 2016 was conducted with assessments of demographic data, clinical symptoms and signs, and pre-operative laboratory results. According to intraoperative findings and postoperative pathological results, acute appendicitis were divided into simple and complicated appendicitis. Univariate and multivariate analyses were used to screen out the independent factors of complicated appendicitis, and develop a prediction model for complicated appendicitis. Then 156 such patients from January 2017 to December 2019 were collected as validation sample to validate the prediction model. Test performance of the prediction model was compared with the ALVARADO score and Pediatric Appendicitis Score (PAS).Results: Of the 382 patients, 244 (63.9 %) had complicated appendicitis. Age, white blood cell count, and duration of symptoms were the independent factors for complicated appendicitis in children younger than five years of age. The final predication model for complicated appendicitis included factors above. In validation sample, the prediction model exhibited a high degree of discrimination (area under the curve [AUC]: 0.830; 95% confidence interval [CI]: 0.762 - 0.885) corresponding to a optimal cutoff value of 0.62, and outperformed the PAS (AUC: 0.735; 95% CI: 0.658 - 0.802), Alvarado score (AUC: 0.733; 95% CI: 0.657 - 0.801).Conclusion: Younger age, higher white blood cell count, and longer duration of symptoms in children younger than five years of age with acute appendicitis are important predictors for complicated appendicitis. The prediction model is a novel but promising method that aids in the differentiation of acute simple and complicated appendicitis.Trial registration: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Tianjin Children's Hospital institutional research committee (approved number L202001).
Presymptomatic transmission and diverse progression of familial clustering COVID-19 cases in Zhoushan, China
Authors: Liu Miao , Liu Leijie , Li Ping , Ding Yibo , Wu Ting , Tang Weina , Wang Zhongfa , Cao Guangwen 
Published: July 2020

Abstract
Background

Novel coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused emerging infectious disease, firstly identified in Wuhan (Hubei, China), is pandemic. However, data concerning presymptomatic SARS-CoV-2 transmission and disease diversity among family members are limited.
Objectives

To investigate the epidemiological and clinical characteristics of presymptomatic transmission-caused familial clustering cases of SARS-CoV-2 infection in Zhoushan island, China.
Methods

All family members were tested for SARS-CoV-2 genomic RNA by quantitative reverse transcription PCR in 3 different samples and serum antibody immunoglobin M (IgM) and IgG against SARS-CoV-2. Exposure identification, laboratory test, and imaging were performed according to the national guideline of COVID-19 (7th edition, China).
Results

Of the 6 cases, index case who ever met his relative with COVID-19 from Xianning, Hubei on January 26–31, 2020, transmitted SARS-CoV-2 to his family members in Zhoushan via visiting family during January 31 and February 3, 2020. The index was identified as common-type COVID-19 on February 6, 2020. All 5 family members were infected with SARS-CoV-2. Of those, a 7-year-old girl was an asymptomatic carrier whereas her grandparents, especially her grandfather, were very sick. Case 6 (grandfather) remained positive for SARS-CoV-2 RNA in his sputum specimen in subsequent 2 months. Case 2 (mother) tested negative for SARS-CoV-2 RNA in all samples but positive for IgM and IgG to SARS-CoV-2 since February 9, 2020.
Conclusions

Presymptomatic transmission of SARS-CoV-2 causes familial cluster of COVID-19. Exposed to the same source of infection, family members present their differences in disease severity and viral clearance.
Syntaxin binding protein 4 as a novel therapeutic target and an effective biomarker for better treatment selection in lung squamous cell carcinoma: A theranostic study
Authors: Bilguun Erkhem-Ochir , Kaira Kyoichi , Kawabata-Iwakawa Reika , Rokudai Susumu , Shimizu Kimihiro , Yokobori Takehiko , Oyama Tetsunari , Shirabe Ken , Nishiyama Masahiko 
Published: July 2020

Abstract
Background
Lung squamous cell carcinoma (LSCC) remains a challenging disease to treat, and further improvements in prognosis are dependent upon the identification of LSCC-specific therapeutic biomarkers and/or targets. We previously found that Syntaxin Binding Protein 4 (STXBP4) plays a crucial role in lesion growth and, therefore, clinical outcomes in LSCC patients through regulation of tumor protein p63 (TP63) ubiquitination.
Methods
To clarify the potential of STXBP4 as a novel therapeutic target and/or a predictive biomarker of therapeutic response, we assessed its prognostic impact of the protein in 144 LSCC patients and examined whether its action pathway is distinct from those of currently used drugs in in vitro experiments including RNA-seq analysis through comparison with the other putative exploratory targets and/or markers.
Results
Kaplan–Meier analysis revealed that, along with ΔNp63 (an isoform of TP63) and vascular endothelial growth factor receptor 2 (VEGFR2), STXBP4 expression signified a worse prognosis in LSCC patients, both in terms of overall survival (OS, P = 0.002) and disease-free survival (DFS, P = 0.041). Multivariate analysis demonstrated STXBP4 to be an independent prognostic factor for poor DFS, while VEGFR2 (P < 0.001) and TP63 (ΔNp63, P < 0.05) were independent prognostic factors for poor OS. The action pathway of STXBP4 on suppression of TP63 (ΔNp63), which results in the and inhibits tumor growth, was unique: Ingenuity pathway analysis using the knowledge database and our RNA-seq analysis in human LSCC cell lines indicated that 35 pathways were activated or inactivated in association with STXBP4, but the action pathway of STXBP4 was distinct from those of other current drug targets: STXBP4, TP63 and KDR (VEGFR2 gene) formed a cluster independent from other target genes of tumor protein p53 (TP53), tubulin beta 3 (TUBB3), stathmin 1 (STMN1) and cluster of differentiation 274 (CD274: programmed cell death 1 ligand 1, PD-L1). STXBP4 itself appeared not to be a potent predictive marker of individual drug response, but we found that TP63, main action target of STXBP4, might be involved in drug resistance mechanisms of LSCC.
Conclusion
STXBP4 could afford a unique therapeutic target and a key to the development of precision medicine for LSCC patients.