bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengthening the role of lawyers and other professional advisers in addressing economic and financial crimes in Indonesia
Authors: Lukito Anastasia Suhartati 
Published: November 2019

Purpose
This paper aims to explain the regulations in Indonesia that apply to lawyers and other professional advisers in terms of their obligations as reporting parties of suspicious financial transactions with respect to money laundering and other financial crimes. As lawyers and other professional advisers offer services to the business community in Indonesia, they are vulnerable to becoming parties to illegal business transactions. The results could lead to bribery, graft, tax crime and corruption in Indonesia.

Design/methodology/approach
This paper explores and analyzes the obligations of lawyers and other professional advisers under Indonesian law, with particular reference to their obligations as reporting parties in efforts to prevent economic crime within the country’s business community.

Findings
Lawyers and other professional advisers, as reporting parties, can be viewed as the gatekeepers that inhibit economic and financial crimes. Consequently, a new perspective is needed for all of the legal professions so that they can protect themselves from the risks of being targeted by nefarious clients/offenders. To strengthen the role of these advisers, it is recommended that both a code of ethics and know your customer principle to be implemented.

Practical implications
This paper can serve as a resource that explores the functions of lawyers and other professional advisers as reporting parties whose aim is to prevent financial and economic crime in Indonesia.

Originality/value
This paper encourages lawyers, other professional advisers, and public and private institutions to implement a code of ethics, and also integrity and professionalism, with a view to preventing economic and financial crimes. According to the code, the functions and obligations of lawyers and other professional advisers include discouraging such offenses. The code becomes effective when legal professionals adhere to legal ethics and integrity.
Patient preference and operating time for digital versus conventional impressions: a network meta‐analysis
Authors: Sivaramakrishnan G , Alsobaiei M , Sridharan K 
Published: November 2019

AbstractBackgroundDigital impression techniques have seen many advancements, with new hardware and software being developed each year. The technical advantages of these systems are real‐time visualization, evaluation and archive, segmental capture, ease of recapture if necessary, economical in terms of no use of impression material or trays or disinfection, easy file transfer and communication with the laboratory. However patient satisfaction is one major factor that might influence the choice of impression technique. The aim of this network meta‐analysis was to identify statistically the evidence on overall patient preferences relative to digital versus conventional impression techniques, in addition to the time taken in making these impressions.MethodologyRandomized or prospective clinical studies were identified based on the inclusion criteria in PUBMED, DARE and COCHRANE databases; subsequently pertinent data were extracted. Risk of bias of the included studies was assessed using the Cochrane risk of bias tool and Newcastle‐Ottawa scale. Heterogeneity amongst the studies in direct comparison was assessed by Chi‐square and I2 tests using the Inverse variance heterogeneity model. Direct comparison estimates were derived by pooling the data from studies that compared the same intervention. Indirect comparison pooled estimates were derived by using the data amongst the studies, through a common comparator, using MetaXL software. Mean differences and Odds ratio at 95% confidence interval were used as the effect estimates, while inconsistencies were evaluated by H‐statistics. GRADE working group approach was used to assess the quality of available evidence.ResultsFourteen studies were included. Results from 11 studies on 471 patients (236‐Digital; 235‐conventional) were pooled for patient preference with 95% confidence interval. The Forest plot showed a pooled estimate of 31.23 [5.95, 163.87], showing a statistically significant number of patients favouring digital impressions. Results from 11 studies reported the time taken in 589 patients (278‐digital; 311 conventional). The pooled estimate (2.72 [0.08, 5.32]) (95% confidence interval) showed a statistically significant increase in the time required to make digital impressions. The overall time taken in minutes for the interventions in the digital group in decreasing order were: LAVA Cos (8.14[3.64,12,26] (statistically significant); I tero (4.11[‐1.02,9.24]; CEREC (0.34[‐4.14,4.82]).ConclusionThere was an overall preference for digital impressions, although the time required is longer. The factors related to the digital system, the operator and the patient were studied, with recommendations forming a basis for possible hardware and software upgrades of the digital systems that can produce significant improvement in the acceptance rate for both the patient and the clinician.
Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis
Authors: Qin Xin , Jiang Ming , Zhao Yan , Gong Jing , Su Hao , Yuan Fen , Fang Ke , Yuan Xiaoyi , Yu Xiao , Dong Hui , Lu Fuer 
Published: November 2019

Background and PurposeDisordered lipid metabolism and disturbed mitochondrial bioenergetics play pivotal roles in the initiation and development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used in Chinese herbal medicine. It has multiple therapeutic actions on diabetes mellitus and its complications, including regulation of glucose and lipid metabolism, improvement of insulin sensitivity, and alleviation of oxidative damage. Here, we investigated the reno‐protective effects of berberine.Experimental ApproachWe used samples from DKD patients and experiments with models of DKD (db/db mice) and cultured podocytes, to characterize energy metabolism profiles using metabolomics. Molecular targets and mechanisms involved in the regulation of mitochondrial function and bioenergetics by berberine were investigated, along with its effects on metabolic alterations in DKD mice.Key ResultsMetabolomic analysis suggested altered mitochondrial fuel usage and generalized mitochondrial dysfunction in patients with DKD. In db/db mice, berberine treatment reversed the disordered metabolism, podocyte damage and glomerulosclerosis. Lipid accumulation, excessive generation of mitochondrial ROS, mitochondrial dysfunction, and deficient fatty acid oxidation in DKD mouse models and in cultured podocytes were suppressed by berberine. These protective effects of berberine were accompanied by activation of the peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) signalling pathway, which promoted mitochondrial energy homeostasis and fatty acid oxidation in podocytes.Conclusion and ImplicationsPGC‐1α‐mediated mitochondrial bioenergetics could play a key role in lipid disorder‐induced podocyte damage and development of DKD in mice. Restoration of PGC‐1α activity and the energy homeostasis by berberine might be a potential therapeutic strategy against DKD.
Employing a Gaussian Particle Swarm Optimization method for tuning Multi Input Multi Output‐fuzzy system as an integrated controller of a micro‐grid with stability analysis
Authors: Mir Mahdi , Dayyani Mohammad , Sutikno Tole , Mohammadi Zanjireh Morteza , Razmjooy Navid 
Published: November 2019

AbstractThere are mainly two most essential problems in power networks, load frequency control and power flow management, which are grown recently because of growth in dimension/complication of grids. Present work suggests a controller based on fuzzy systems in which controller design is performed in a supervisory manner over a multiagent system aiming to control the frequency variation as well as generation cost minimization in the entire grid. The designing processes for low‐frequency controller (LFC) and management are mostly performed separately, which results in the disruption of both outputs. This challenge is tackled in this paper by the integration of them in the designing process. Additionally, stability guarantee is in high importance in the power systems, which is neglected in most of the related works. The Gaussian particle swarm optimization (GPSO) algorithm is applied for determining the optimal values of the decision variables, which can also guarantee the stability of the system by adopting a chaotic map by Gaussian function to balance the seeking abilities of particles that promotes the computation effectiveness without affecting the efficiency of the fuzzy controller. Then, the stability situationof the fuzzy + GPSO method is derived that guarantees a suitable global exploration and rapid convergence, with no require to gradients.
Occlusal support is associated with nutritional improvement and recovery of physical function in patients recovering from hip fracture
Authors: Sawa Yukiko , Kayashita Jun , Nikawa Hiroki 
Published: November 2019

AbstractObjectiveThis study aimed to elucidate the association between occlusal support and nutritional improvement and recovery of activities of daily living (ADLs) among elderly patients recovering from hip fracture.BackgroundMany patients with hip fracture are malnourished, and malnutrition is associated with poor functional outcomes. Poor oral status is one reason for malnutrition because loss of occlusal support leads to masticatory disorders and can cause nutrient deficiencies.MethodsWe evaluated 202 elderly patients aged 65 years and older (mean age, 84.9 ± 7.9 years). We assessed nutritional status using the Mini Nutritional Assessment‐Short Form and ADLs using functional independence measure (FIM) scores. Occlusal support was recorded in accordance with the Eichner Index. We categorised participants into two groups according to the presence or absence of occlusal support, and statistical analyses were performed to investigate the differences between the groups.ResultsOne group contained 152 participants (mean age, 85.5 ± 7.4 years) with occlusal support, and the other group contained 50 participants (mean age, 83.0 ± 8.9 years) without occlusal support. The group with occlusal support had greater gain of FIM and higher FIM efficiency than did the other group. Multivariate analyses showed that occlusal support was independently associated with nutritional improvement [odds ratio (OR) = 4.00, 95% confidence intervals (CI) = 1.90‐8.43] and motor FIM efficiency (R2 = .338,P < .001).ConclusionsOur findings suggest that occlusal support is associated with nutritional improvement and the recovery of ADLs in patients recovering from hip fracture.
Magnetic resonance imaging/transrectal ultrasonography fusion targeted prostate biopsy finds more significant prostate cancer in biopsy‐naïve Japanese men compared with the standard biopsy
Authors: Fujii Shinsuke , Hayashi Tetsutaro , Honda Yukiko , Terada Hiroaki , Akita Ryuji , Kitamura Naoyuki , Ueda Eikoh , Han Xiangrui , Ueno Takeshi , Miyamoto Shunsuke , Kitano Hiroyuki , Inoue Shogo , Teishima Jun , Abdi Hamidreza , Awai Kazuo , Takeshima Yukio , Sentani Kazuhiro , Yasui Wataru , Matsubara Akio 
Published: November 2019

ObjectiveTo assess the clinical benefits of magnetic resonance imaging/transrectal ultrasound fusion‐targeted biopsy for biopsy‐naïve Japanese men.MethodsBetween February 2017 and August 2018, 131 biopsy‐naïve men who underwent targeted biopsy together with 10‐core systematic biopsy at Hiroshima University Hospital were retrospectively investigated. Multiparametric magnetic resonance imaging findings were reported based on Prostate Imaging Reporting and Data System version 2.ResultsThe overall cancer detection rates per patient were 69.5% in systematic biopsy + targeted biopsy cores, 61.1% in systematic biopsy cores and 61.1% in targeted biopsy cores. The detection rates for clinically significant prostate cancer were 43.5% in targeted biopsy cores and 35.9% in systematic biopsy cores (P = 0.04), whereas the detection rates for clinically insignificant prostate cancer were 17.6% and 25.2% respectively (P = 0.04). Lesions in the peripheral zone were diagnosed more with clinically significant prostate cancer (54.8% vs 20.7%, P < 0.001) and International Society of Urological Pathology grade (3.2 vs 2.7, P = 0.02) than that in the inner gland. Just 4.2% (3/71) of Prostate Imaging Reporting and Data System category 2 and 3 lesions in the middle or base of the inner gland were found to have clinically significant prostate cancer. The cancer detection rate per core was 42.3% in targeted biopsy cores, whereas it was 17.9% in systematic biopsy cores (P < 0.001).ConclusionsTargeted biopsy is able to improve the diagnostic accuracy of biopsy in detection of clinically significant prostate cancer by reducing the number of clinically insignificant prostate cancer detections compared with 10‐core systematic biopsy in biopsy‐naïve Japanese men. In addition, the present findings suggest that patients with Prostate Imaging Reporting and Data System category 2 or 3 lesions at the middle or base of the inner gland might avoid biopsies.
Endoscopic alterations in Peyer's patches in patients with ulcerative colitis: A prospective, multicenter study
Authors: Hiyama Satoshi , Iijima Hideki , Sakakibara Yuko , Yamada Takuya , Mukai Akira , Otake Yuriko , Yamaguchi Toshio , Araki Manabu , Kawai Shoichiro , Tsujii Yoshiki , Inoue Takahiro , Hayashi Yoshito , Shinzaki Shinichiro , Takehara Tetsuo 
Published: November 2019

AbstractBackground and AimPeyer's patches (PPs) play a major role in intestinal mucosal immunity; however, their role in ulcerative colitis (UC) is not well investigated. We evaluated endoscopic features of PPs on narrow‐band imaging with magnifying endoscopy (NBI‐ME) and investigated their association with clinical factors.MethodsWe prospectively recruited 105 patients with UC, 18 with Crohn's disease, 16 with disease control, and 33 healthy control subjects at three institutions from 2014 to 2017. NBI‐ME images of the villi of PPs were evaluated according to the Villi Index, and patients were divided into the Villi Index low (L) and high (H) types. The 1‐year sustained clinical remission rate was evaluated between L‐type and H‐type PPs in patients with UC.ResultsThe proportions of patients with H‐type PPs were significantly higher among UC, Crohn's disease, and disease control patients than among healthy control patients (P = 0.0125, 0.018, 0.0007). In UC, age, gender, endoscopic score, and extent of disease involvement were not significantly different between L‐type and H‐type PPs, whereas the sustained clinical remission rate was significantly higher in L‐type PPs than in H‐type PPs (88% [57/65] vs 65% [17/26], P = 0.019). Multivariate analysis revealed that the L type of PPs was a significant factor for sustained clinical remission (odds ratio 3.8, 95% confidence interval 1.1–12.9, P = 0.033).ConclusionsPatients with UC showed endoscopic alterations in PPs on NBI‐ME, and highly altered appearance of PPs can be associated with a high risk of clinical relapse in patients with UC.
Genetic components of root architecture and anatomy adjustments to water‐deficit stress in spring barley
Authors: Oyiga Benedict C. , Palczak Janina , Wojciechowski Tobias , Lynch Jonathan P. , Naz Ali A , Léon Jens , Ballvora Agim 
Published: November 2019

AbstractRoots perform vital roles for adaptation and productivity under water‐deficit stress, even though their specific functions are poorly understood. In this study, the genetic control of the nodal‐root architectural and anatomical response to water deficit were investigated among diverse spring barley accessions. Water deficit induced substantial variations in the nodal root traits. The cortical, stele, and total root cross‐sectional areas of the main‐shoot nodal roots decreased under water deficit, but increased in the tiller nodal roots. Root xylem density and arrested nodal roots increased under water deficit, with the formation of root suberization/lignification and large cortical aerenchyma. Genome‐wide association study implicated 11 QTL intervals in the architectural and anatomical nodal root response to water deficit. Among them, three and four QTL intervals had strong effects across seasons and on both root architectural and anatomical traits, respectively. Genome‐wide epistasis analysis revealed 44 epistatically interacting SNP loci. Further analyses showed that these QTL intervals contain important candidate genes, including ZIFL2, MATE, and PPIB, whose functions are shown to be related to the root adaptive response to water deprivation in plants. These results give novel insight into the genetic architectures of barley nodal root response to soil water deficit stress in the fields, and thus offer useful resources for root‐targeted marker‐assisted selection.
Abscisic acid‐triggered guard cell l‐cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase‐modulated stomatal closure
Authors: Zhang Jing , Zhou Mingjian , Ge Zhenglin , Shen Jie , Zhou Can , Gotor Cecilia , Romero Luis C. , Duan Xingliang , Liu Xin , Wu Deliang , Yin Xianchao , Xie Yanjie 
Published: November 2019

AbstractRecent studies have demonstrated that hydrogen sulfide (H2S) produced through the activity of l‐cysteine desulfhydrase (DES1) is an important gaseous signaling molecule in plants that could participate in abscisic acid (ABA)‐induced stomatal closure. However, the coupling of the DES1/H2S signaling pathways to guard cell movement has not been thoroughly elucidated. The results presented here provide genetic evidence for a physiologically relevant signaling pathway that governs guard cell in situ DES1/H2S function in stomatal closure. We discovered that ABA‐activated DES1 produces H2S in guard cells. The impaired guard cell ABA phenotype of the des1 mutant can be fully complemented when DES1/H2S function has been specifically rescued in guard cells and epidermal cells, but not mesophyll cells. This research further characterized DES1/H2S function in the regulation of LONG HYPOCOTYL1 (HY1, a member of the heme oxygenase family) signaling. ABA‐induced DES1 expression and H2S production are hyper‐activated in the hy1 mutant, both of which can be fully abolished by the addition of H2S scavenger. Impaired guard cell ABA phenotype of des1/hy1 can be restored by H2S donors. Taken together, this research indicated that guard cell in situ DES1 function is involved in ABA‐induced stomatal closure, which also acts as a pivotal hub in regulating HY1 signaling.
Altitude Test Facility Humidity Control to Generate Defined Icing Conditions
Authors: Barth Felix M. , Staudacher Stephan , Schiewe Constanze 
Published: November 2019

Abstract
In altitude test facility (ATF) operation, the requirements to control humidity to generate defined icing conditions are gaining more and more importance. In this context, the ability to predict humidity and condensation becomes a fundamental part of ATF control. For this purpose, classical nucleation theory has been applied in combination with in situ measurements to derive a model suitable to predict the onset of condensation during very low temperature ATF operation. The model parameters have been acquired inside the ATF of the University of Stuttgart downstream of its air coolers. This makes the application or assumption of generalized atmospheric aerosol data unnecessary. Polydisperse nano aerosol distributions were measured and statistically evaluated, showing that a constant distribution of nano aerosol particle size can be assumed. The composition of the ingested nanoparticles was analyzed and Arizona test dust was chosen as a valid substitute material for the application in the prediction model leading to a conservative prediction. The approach has been successfully verified using optical measurements during ATF testing. Its prediction accuracy fulfills the requirements of ATF control for a variety of icing conditions in component and engine altitude testing.
Ultrafast X-Ray Computed Tomography Imaging for Hydrodynamic Investigations of Gas–Liquid Two-Phase Flow in Centrifugal Pumps
Authors: Schäfer Thomas , Neumann-Kipping Martin , Bieberle André , Bieberle Martina , Hampel Uwe 
Published: November 2019

AbstractGas entrainment into centrifugal pumps decreases pump performance and may raise safety issues, e.g., through insufficient cooling. Although there is some phenomenological knowledge in the form of correlations between operating parameters and pump performance, a further understanding via direct observation of the gas–liquid mixture was so far not possible. In this paper, we demonstrate the capability of ultrafast X-ray computed tomography (UFXCT) to disclose gas–liquid two-phase flow dynamics in the impeller region of a centrifugal pump mockup. Experiments were performed for gas injection at impeller speeds between 1300 rpm and 1600 rpm. We analyzed the X-ray image sequences with respect to characteristics of the gas distribution and compared them with time-averaged image data of a real pump obtained earlier with gamma-ray computed tomography (CT).