bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodegradable hollow mesoporous organosilica nanotheranostics (HMON) for multi-mode imaging and mild photo-therapeutic-induced mitochondrial fusion on gastric cancer
Authors: Guo Weihong , Chen Zhian , Chen Jiajia , Feng Xiaoli , Yang Yang , Huang Huilin , Liang Yanrui , Shen Guodong , Liang Yu , Peng Chao , Li Yanbing , Li Guoxin , Huang Wenhua , Zhao Bingxia , Hu Yanfeng 
Published: April 2020

Abstract
CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been been preferred as non-invasive treatment for cancer, as near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic effect (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric cancer (GC) cells’ mitochondrial fusion, remained unclear. Moreover, theranostic eﬃciency of HMON@CuS might be well improved by applying multi-modal imaging which could offer an optimal therapeutic region and time window. Herein, new nanotheranostics agents were reported by Gd doped HMON decorated by CuS nanocrystals (called HMON@CuS/Gd), which exhibited appropriate size distribution, good biocompatibility, L-Glutathione (GSH) responsive degradable properties, high photo-thermal conversion eﬃciency (82.4%) and a simultaneous reactive oxygen species (ROS) generation effect. Meanwhile, HMON@CuS/Gd could efficiently enter GC cells, induce combined PDT and mild PTT (43-45 °C) under mild NIR power density (0.8W/cm2). Surprisingly, it was found that PTT might not be the key factor of cell apoptosis, as ROS induced by PDT seems playing a more essential role. The NIR-induced ROS could attack mitochondrial membrane potentials (MTPs), then promote mitochondrial reactive oxygen species (mitoROS) production. Meanwhile, mitochondrial fusion dramatically changed the expression of anti-apoptotic protein (Bcl-2) and pro-apoptotic protein (Bax). Since that, mitochondrial permeability transition pore (mPTP) was opened, followed by inducing more cytochrome c (Cyto C) releasing from mitochondria into cytosol, and finally activated caspase-9/caspase-3-depended cell apoptosis pathway. Our in vivo data also showed that HMON@CuS/Gd exhibited good fluorescence (FL) imaging (wrapping fluorescent agent), enhanced T1 imaging under magnetic resonance imaging (MRI) and infrared thermal (IRT) imaging capacities. Guided by FL/MRI/ IRT trimodal imaging, HMON@CuS/Gd could selectively cause mild photo-therapy at cancer region, efficiently inhibit the growth of GC cells without evident systemic toxicity in vivo. Taken together, HMON@CuS/Gd could serve as a promising multifunctional nanotheranostic platform and as a cancer photo-therapy agent through inducing mitochondrial fusion on GC.
A study on synthesis and characterization of Dy-dopedLa0.6Sr0.4Co0.2Fe0.8O3-δvia co precipitation method
Authors: Mohammadi Negin , Khakpour Zahra , Maghsoudipour Amir , Faeghinia Aida 
Published: April 2020

Abstract
The perovskite Lanthanum Strontium Cobalt Ferrite (LSCF) is investigated as the cathode material used in intermediate temperature solid oxide fuel cells (IT-SOFCs). In the present study, La0.6-xDyxSr0.4Co0.2Fe0.8O3-δ(x= 0, 0.3, 0.6) was synthesized through co precipitation method. The obtained precipitate was calcined at500, 700,900and 1000°С. Phase characterization of synthesized LSCF and LDySCF powder before and after heat treatment at 700°Сwas carried out by X-ray diffraction (XRD) analysis. XRD patterns revealed that the perovskite phase was obtained at 700 °С in all calcined samples. Chemical bond study to investigate synthesis process was done using the Fourier transform infrared spectroscopy technique. Thermalanalysis of DTA and TG has been utilized to investigate how the calcination temperature affects the peroveskite phase formation. According to the STA results, the perovskite phase formation started at 551°Сafterwarditcompleted at 700°С.The density values of synthesized powders were 6.10, 6.11 and 6.37g.cm-3for the undoped and doped samples calcined at 700°С. Powder morphology was studied by Field emission scanning electron microscopy. (FE-SEM) micrographs showed the spherical shaped particles with the average particle size of 24-131nm.
Clinical patterns and the evolution of relapsing polychondritis based on organ involvement: a Chinese retrospective cohort study
Authors: Zhang Lei , Yun Shuang , Wu Tiange , He Yujie , Guo Jinyan , Han Lishuai , Lu Jiameng , Liu Xiaojun , Yang Rui , Zhang Shitao , Li Tianfang , Liu Shengyun 
Published: April 2020

Abstract
BackgroundRelapsing polychondritis(RPC) is a rare autoimmune disease, of which the diagnosis in early stage is challenging. Defining the clinical patterns and disease evolution may help early recognition of this rare disease.ResultsSixty-six males and 60 females were included with onset age of 47.1±13.8 years and followed up for a median of 18 months. Correlation analysis revealed a strong negative correlation between airway involvement and auricular chondritis (r=-0.75，P<0.001). Four distinct clinical patterns were identified: Ear pattern (50.8%), Airway pattern (38.9%), Overlap pattern (4.8%) and Airway-Ear negative pattern (5.6%) and patients with Ear pattern and Airway pattern were subdivided as limited and systemic form of RPC (27.8% with limited form of Ear pattern and 24.6% with limited form of Airway pattern). During follow-up, a small part of patients with Ear pattern and Airway pattern progressed into Overlap pattern and some Airway-Ear negative pattern patients progressed into Ear pattern. Most of the limited RPC patients remained limited form during follow-up while some patients with limited form progressed into systemic form. Patients with Ear pattern had the highest survival rate and relative lower inflammatory status.ConclusionsRPC patients can be categorized as 4 different clinical patterns and 2 distinct presenting forms (limited and systemic) based on organ involvement, and clinical patterns and presenting forms can evolve during follow-up. Our findings may facilitate early recognition of this rare disease and contribute to an updated classification criteria covering all the clinical spectrum of RPC
The Prevalence of Physical Inactivity in Iranian Children and the Impact of Economic and Social Inequalities on it: Results of a National Study in 2018
Authors: Moradi Ghobad , Mostafavi Farideh , Piroozi Bakhtiar , Zareie Bushra , Mahboobi Marzieh , Rasouli Mohammad Aziz Aziz 
Published: April 2020

Abstract
Background: Physical inactivity (PI) is a public health concern around the world that has been growing with the advent of technology. It has often been studied in adults. This study aims to determine the prevalence of physical inactivity in Iranian children aged 10-12 years and the impact of socioeconomic inequality on it.Methods: In this descriptive study, the study population consisted of 10-12 years old children from an Iranian population from Kurdistan, Fars and Markazi provinces in 2018. The sample size was 1590 individuals. The sampling method was cluster sampling. Data was collected using demographic questionnaire, modifiable activity questionnaire (MAQ) and socioeconomic questionnaire. Linear and logistic regression were used to estimate the final model and the Oaxaca analysis method was applied. All analyses were performed in Stata/SE 14.0.Results: Of the 1590 participants, 52.82% were male. The results showed that 25.79% of the subjects had physical inactivity and 7.30% had moderate physical activity during the week. The average physical activity during one week was more in boys than in girls (P-value<0.05). Children of mothers with secondary and high school education were more likely to have physical inactivity than mothers with a high school diploma or higher (AOR: 1.35, 95% CI: 1.02 - 1.77). The concentration index was -.11, indicating a greater concentration of physical inactivity in children with low socioeconomic levels. Results: One-fourth of the study population had physical inactivity in this age group and required serious interventions. Socioeconomic levels, parental literacy, and children’s sex were factors affecting the level of physical activity. Raising parental awareness, designing specific programs for girls, such as increasing access to sports facilities, are strategies to reduce physical inactivity in children.
Abortion and the risk of suicide：a systematic review and meta-analysis
Authors: Zheng Linli , Yang Yi , Zhang Yonggang 
Published: April 2020

Abstract
Background Abortion had been suggested to be associated with the risk of suicide with inconclusive results. The objective of this study was to assess the association by systematic review and meta-analysis.Methods We searched PubMed, EMbase, PsycINFO, CNKI, WanFang Data and VIP databases for all studies investigating the association between abortion and the risk of suicide. We included Studies investigating the association between abortion and the risk of suicide. Two reviewers collected the data and assessed risk of bias of included studies. Outcomes included completed suicide, suicide behavior, and suicidal ideation. Data were analyzed by using Revman5.2 software. Results A total of 13 studies were included in the meta-analysis, including 1 case-control study, 6 cohort studies, and 6 cross-sectional studies. The results of meta-analysis showed that, abortion might be associated with increased risk of completed suicide (OR=3.16, 95CI 2.49 to 3.99, P <0.00001), suicide behavior (OR=1.92, 95CI 1.64 to 2.26, P <0.00001) and suicidal ideation (OR=1.52, 95%CI 1.32 to 1.75, P <0.00001).Conclusions The current meta-analysis suggested that abortion might be associated with increased risk of suicide. Due to the limited quality and quantity of included studies, more high-quality studies are needed to verify the above conclusions.
Cryoablation versus radiation therapy for low and intermediate risk localized prostate cancer: a propensity score-adjusted cohort analysis of oncologic outcomes
Authors: Chen Bo , Jin Kun , Qiu Shi , Chen Zeyu , Li Jin , Huang Yin , Lin Tianhai , Ai Jianzhong , liu liangren , Wei Qiang 
Published: April 2020

Abstract
Background: We are aiming to compare the oncologic outcomes between cryoablation and radiation therapy for low or intermediate risk localized prostate cancer. Methods : Among patients diagnosed between 2004 and 2016 in SEER databases, we identified cases confirmed low or intermediate risk prostate adenocarcinoma treated with radiation treatment (n = 93041) or cryoablation (n = 2350). Propensity score matching (PSM) was performed. Kaplan-Meier method, Cox proportional hazards model were used to calculate cancer specific mortality (CSM) and overall survival (OS) in the unmatched and matched cohort, and in subgroups based on clinical characteristics. Results: A total of 95391 patients who were diagnosed with first prostate adenocarcinoma and treated with radiation treatment (97.54%) or cryoablation (2.46%) were identified. In the matched cohort, cryoablation group has similar CSM (HR 1.13, 95%CI 0.72-1.77, P=0.6) and worse OS (HR 1.20, 95%CI 1.04-1.39, P=0.01) than radiation treatment group in the non-adjusted model as well as those in the adjusted model (HR 1.06, 95%CI 0.68-1.65, P=0.8; HR 1.18, 95%CI 1.02-1.36, P=0.02, respectively). For low risk disease, CSM and OS outcomes were similar between cryoablation and radiation treatment group. Last but not least, for intermediate risk patients, compared with radiation treatment group, cryoablation group has similar CSM (HR 1.26, 95%CI 0.90-1.77, P=0.2) and inferior OS (HR 1.17, 95%CI 1.04-1.32, P=0.01). Conclusion: In summary, for low risk disease, CSM and OS outcomes were similar between cryoablation and radiation treatment group. For intermediate risk disease, we found that radiation treatment group showed superior OS than cryoablation group.
Fast and slow-growing breeds: characterisation of broiler caecal microbiota development throughout the growing period
Authors: Dasí Laura Montoro , Villagra Arantxa , Toro Maria de , Pérez-Gracia María Teresa , Vega Santiago , Marin Clara 
Published: April 2020

Abstract
Background: The caecal microbiota and its modulation play an important role in animal health, productivity and disease control in poultry production. In this sense, it could be considered as a biomarker of poultry health. Furthermore, due to the emergence of resistant bacteria and the increasing social pressure to establish animal-friendly management on farms, producers are motivated to select more extensive and antibiotic-free breeds. It is therefore necessary to gain better knowledge on the development of major bacteria in healthy broilers, both in commercial fast-growing and in new slow-growing breeds. Hence, the aim of this study was to characterise caecal microbiota in two genetic poultry breeds throughout the growing period using 16S rRNA sequencing analysis. Results: A total of 50 caecal pools (25 per breed) were sequenced by the 16S rRNA method. The complexity of caecal microbiota composition increased significantly as animals grew. Furthermore, there were statistical differences between breeds at the end of the growing period. The dominant phyla throughout the production cycle were Firmicutes, Bacteroidetes and Proteobacteria. The predominantly identified genera were Ruminococcus spp., Lactobacillus spp. and Bacteroides spp.Conclusion: The results showed that the main caecal bacteria for both breeds were similar. Thus, these phyla or genera should be considered as biomarkers of poultry health in the evaluation of different treatments applied to animals.
Associations between vascular risk factors and subsequent Alzheimer’s disease in older adults
Authors: Lee Hyewon , Kim Kiwon , Lee Yeong Chan , Kim Soyeon , Won Hong-Hee , Yu Tae Yang , Lee Eun-Mi , Kang Jae Myeong , Lewis Matthew , Kim Doh Kwan , Myung Woojae 
Published: April 2020

Abstract
Background: The clinical guidelines related to the primary prevention of Alzheimer’s disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 older adults (age: ≥65 years).Methods: Participants were recruited from 2009 through 2010 and followed up for 6 years. We assessed various vascular risk factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], fasting glucose [FG], systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP] and body mass index [BMI]) and their association with AD incidence, categorizing each vascular factor using current clinical guidelines.Results: AD was observed in 6.0% of participants at follow-up. All lipid profiles (TC, LDL-C, HDL-C, TG) were positively associated with the risk of AD. SBP and PP were in negative associations with AD, and DBP was positively associated with AD. BMI exhibited a negative association with AD incidence. We found no significant association between FG and AD risk. The sex difference was observed to have effects on vascular risk factors.Conclusions: In this study, we comprehensively investigated the association between eight vascular risk factors and the risk of incident AD. Our findings suggest that multiple vascular risk factors are related to the development of AD in older adults. These results can help inform future guidelines for reducing AD risk.
Fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells
Authors: Yuan Yin , Li Bo , Kuang Yanbin , Ni Shuo , Zhuge Aoxiang , Yang Jing , Lv Longxian , Gu Silan , Yan Ren , Li Yating , Wang Kaicen , Yang Liya , Zhu Xueling , Wu Jingjing , Bian Xiaoyuan , Li Luanjuan 
Published: April 2020

Abstract
Background: Dietary fibers are effective for Colorectal cancer (CRC) treatment. Interleukin-6 (IL-6) and its adaptors are potential targets for CRC therapy. Butyrate, a metabolite of dietary fiber, is a new, highly safe type of targeted drug.Methods: In this study, Cell Counting Kit-8 cell viability and wound healing assays, western blot analysis, immunofluorescence staining and xenograft tumor mouse models were used to evaluate the anticancer effect of butyrate and its possible mechanism in vivo and in vitro.Results: Dietary fibers and sodium butyrate (NaB) decreased CRC burden by decreasing IL-6 receptor gp130 and blocking IL-6/JAK2/STAT3 axis activation in vitro and in vivo. Furthermore, NaB reduced gp130 protein level by regulating its degradation rate via targeting TRAF5.Conclusions: Fiber metabolite butyrate inhibits CRC development by reducing gp130 via TRAF5.
Dietary behaviours associated with metabolic syndrome: a latent class analysis
Authors: Park Jung Ha , Kim Ju Young , Kim So Hye , Kim Jung Hyun , Park Young Mi , Yeom Hye seon 
Published: April 2020

Abstract
Background Obese individuals have a number of dietary behaviours that might contribute to their weight-related health risks. However, obesity defined solely by body mass index may not reflect the true heterogeneity of the obese population. The aims of this study were to classify the dietary behaviours of obese individuals into subgroups and to explore the relationship between their patterns of dietary behaviour and cardiometabolic risk factors. Methods The study participants were 259 patients who visited an outpatient weight management clinic at a tertiary hospital and underwent a dietary behaviour assessment between January 2014 and February 2019. Dietary behaviours were assessed in three domains with nine categories, including choice of food (frequent eating out, instant/fast/takeaway food), eating behaviour (irregular meals, frequent snacking, including eating at night, emotional eating, and overeating/binge eating), and nutrient intake (high fat/high calorie foods, salty food, and poorly balanced diet). Latent class analysis (LCA) was used to classify the subjects according to these nine categories of dietary behaviour. Associations between latent class and metabolic syndrome were assessed in a logistic regression model. Results Based on their dietary behaviour, the subjects were classified into three LCA-driven classes, including a referent class of healthy eaters (n=118), a class of emotional eaters (n=53), and a class of irregular unhealthy eaters (n=88). Compared with the referent class, emotional eaters had a significantly higher body mass index (beta=3.40, P<0.001) and metabolic syndrome (odds ratio 2.88, 95% confidence interval 1.16–7.13). Conclusions Our finding of three LCA-driven obesity phenotypes could be useful for assessment and management of obesity and metabolic syndrome. The association between higher BMI and metabolic syndrome was stronger in emotional eaters than in healthy eaters and irregular unhealthy eaters. Emotional eaters might benefit from emotional regulation strategies.
Predictors and survival of Primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
Authors: Wen Jie , Aili Abudureyimujiang , yao xueyan , Wang Junjie , xue li xiang 
Published: April 2020

Abstract
Background: The clinicopathological features and prognostic factors of primary clear cell carcinoma of the liver (PCCCL) remain unknown. Aims: We aimed to determine the clinical, pathological, demographic, and therapeutic characteristics of PCCCL and the effects of these factors on the prognosis. Methods: Patients were selected from the "Surveillance, Epidemiology and End Results" (SEER) database. Data were analyzed with the Kaplan-Meier, Cox proportional hazards regression, and multivariate ordinal regression analyses. Results: We included 248 PCCCL patients with an average age of 64.1 years. The majority (50.4%) had low pathological grade (grade I/II). The 3-, 5-, and 10-year overall survival (OS) probabilities and disease-specific survival (DSS) rates were 33.8%, 23.2%, 12.2%, and 39.8%, 28.3%, 19.1%, respectively. The widowed patients (OS, P=0.271; DSS, P=0.022) with tumor ≥ 1 cm (OS, P=0.001; DSS, P=0.002) had a higher risk of death. Uninsurance and medicaid were independently associated with a shorter survival (OS, P=0.029; DSS, P=0.017). Among surgical means, total proctectomy along with total colectomy, and wedge or segmental resection/partial proctosigmoidectomy were more beneficial to PCCCL. The black PCCCL patients had a poorer survival than the white group. Furthermore, pathological grade I PCCCL was more likely to present AJCC stage I (P=0.005, OR=-1.062). Conclusion: PCCCL patients had a poor outcome. PCCCL was inclined to be localized, male-prevalent and lower pathological grade. Insurance, tumor size, and marital status were independent prognostic factors for OS and DSS, whereas race affected only OS. Surgery could improve OS and DSS. Moreover, highly differentiated PCCCL was susceptible to early AJCC stage.
The Feasibility and Impact of a Yoga Intervention on Cognition, Physical Function, Physical Activity, and Affective Outcomes Among People Living with HIV: A Randomized Controlled Pilot Trial
Authors: Quigley Adria , Brouillette Marie-Josée , Gahagan Jacqueline , O'Brien Kelly K. , MacKay-Lyons Marilyn 
Published: April 2020

Abstract
The purpose of this pilot randomized controlled trial was to assess the feasibility and impact of a tri-weekly 12-week yoga intervention among people living with HIV (PLWH). Additional objectives included evaluating cognition, physical function, medication adherence, health-related quality of life (HRQoL), and mental health among yoga participants versus controls using blinded assessors. We recruited 22 medically-stable PLWH aged ≥35 years. A priori feasibility criteria were ≥70% yoga session attendance and ≥70% of participants satisfied with the intervention using a post-participation questionnaire. Two participants withdrew from the yoga group. Mean yoga class attendance was 82% with 100% satisfaction. Intention-to-treat analyses (yoga n=11, control n=11) showed no within- or between-group differences in cognitive and physical function. The yoga group improved over time in HRQoL cognition (p=.047) with trends toward improvements in HRQoL health transition (p=.063) and depression (p=.055). This pilot study provides preliminary evidence of feasibility and benefits of yoga for PLWH.