bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Criteria for Selective Exploration of Orbital Floor in Zygomaticomaxillary Complex Fractures
Authors: Anehosur Venkatesh , Nathani Jayesh , Nagraj Nikhil , Nikhil Krithi 
Published: May 2020

Purpose: Exposing the orbital floor requires a surgical procedure that has its own challenges. Despite the meticulous clinical examination followed by sophisticated imaging modalities, orbital floor defects associated with zygomaticomaxillary complex (ZMC) fractures may evade diagnosis and appropriate management. If surgeons can decide about the need for orbital floor exploration in patients with ZMC fracture, the chance of a postoperative eyelid deformity can be prevented. The aim of this article is to assess whether an association exists between the pattern of fracture line and the need for exploration of the orbital floor in ZMC fracture. Materials and Methods: A retrospective study of 94 patients with isolated, unilateral ZMC fractures who were treated at our unit by open reduction of the ZMC complex with internal orbital exploration from January 2016 to January 2018. The records of all patients were reviewed and specific data related to fracture pattern and orbital floor defect were registered and assessed. Results: Of the 94 cases with isolated, unilateral ZMC fractures, in 80 cases the fracture line propagated to the orbital floor, which required exploration but did not required any reconstruction and only the infraorbital rim was addressed; 14 of them required orbital floor reconstruction. Among the cases which required orbital floor reconstruction, the majority of the cases where those with fracture involving medial side of infraorbital foramen (n = 10) followed by lateral side (n = 3) and through the foramen (n = 0) and lastly bilateral side of the foramen (n = 1). Conclusion: The present study highlights the pattern of fracture line at the level of infraorbital rim can predict the need for orbital floor exploration while treating ZMC fractures for purpose of orbital floor reconstruction. Based on the results and a review of the records, authors strongly recommend the need for exploration of orbital floor when the fracture line passes medial to the infraorbital foramen.
The Utility of Postoperative Computed Tomography Imaging Following Isolated Orbital Blowout Fracture Repair
Authors: Francomacaro Sara E. , Bregman Jana A. , Vakharia Kalpesh T. , Grumbine Francis L. 
Published: May 2020

Purpose: To determine the clinical utility of computed tomography (CT) imaging following isolated orbital blowout fracture (OBF) repair. Methods: Single-center retrospective review of adult patients undergoing surgical repair of isolated OBFs between November 2008 and August 2016 who received postoperative CT scans. Preoperative and postoperative examination data, postoperative imaging reads, postoperative courses, and any reoperation documentation were collected from electronic medical records. Postoperative imaging findings were categorized as major, indeterminate, or minor by predicted impact on clinical management. Major findings indicated a need for reoperation, indeterminate a potential reoperation, and minor no reoperation. Results: Fifty-two cases met inclusion criteria: 94.2% (n = 49) of postoperative scans included minor findings, 34.6% (n = 18) indeterminate findings, and 19.2% (n = 10) major findings. Three patients returned to the operating room (OR) for surgical revision. All 3 had a significant and concerning change on postoperative examination. Only 1 also had a major finding on postoperative imaging. The remaining 49 patients had benign postoperative examinations, despite 9 (17.3%) with major imaging findings who did not undergo reoperation. Conclusions: In the majority of OBF repairs, postoperative CT scan findings were not predictive of a need to return to the OR for revision. Reoperation was instead largely prompted by concerning changes in the postoperative clinical examination. Our findings suggest that postoperative imaging in the absence of clinical concern should not be included in the surgical management of isolated OBFs. Instead, targeted imaging will help reduce radiation exposure and health-care costs without sacrificing patient care.
Increased incidence of venous thromboembolism following hip or knee arthroplasty in winter
Authors: Jones Christopher Wynne , Parsons Richard , Yates Piers J 
Published: May 2020

Background: Deep vein thrombosis (DVT) and pulmonary embolism (PE) cause significant morbidity and mortality following arthroplasty. A seasonal variation in the rate of PE in arthroplasty patients in the northern hemisphere has been reported. We hypothesized that there would be a similar seasonal variation in arthroplasty patients in Australia. Methods: We performed a retrospective review of all patients who received primary and/or revision arthroplasty of the hip or knee over a 15-year period (2000–2015) across Western Australia. We identified all patients who were diagnosed with DVT and/or PE according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Australian Modification codes. The incidence of venous thromboembolic (VTE) disease was calculated as the proportion of operations that led to this complication per 3-month seasonal period. Results: A total of 12,507 total hip arthroplasties (THAs) and 8899 total knee arthroplasties (TKAs) were recorded during the study period. There was a total of 274 DVT and/or PE among the combined total of 21,406 hip and knee arthroplasties performed between 2000 and 2015. There was a significantly higher rate of VTE for females than males (odds ratio (OR): 1.33, 95% confidence interval (CI): 1.03–1.71, p = 0.0293), for TKA than THA (OR: 1.60, 95% CI:1.26–2.03, p < 0.0001) and in winter than other seasons (OR: 1.51, 95% CI: 1.14–2.01, p = 0.0047). Conclusion: There is a statistically significant increase in the incidence of VTE in arthroplasty patients during the winter months in Western Australia. This finding is the first of its kind for patients in the southern hemisphere and corroborates previous studies in the northern hemisphere.
Combined ACL and Anterolateral Reconstruction Is Not Associated With a Higher Risk of Adverse Outcomes: Preliminary Results From the SANTI Randomized Controlled Trial
Authors: Sonnery-Cottet Bertrand , Pioger Charles , Vieira Thais Dutra , Franck Florent , Kajetanek Charles , Fayard Jean-Marie , Thaunat Mathieu , Saithna Adnan 
Published: May 2020

Background: The widespread historical abandonment of lateral extra-articular procedures in anterior cruciate ligament (ACL) injuries occurred as a result of concerns about high rates of adverse events. Recently, the popularity of lateral extra-articular procedures has resurged, warranting an urgent evaluation of their safety profile. Purpose/Hypothesis: The aim of this study was to perform an interim analysis of the ongoing SANTI randomized controlled trial to determine whether combined ACL and anterolateral ligament reconstruction (ACL + ALLR) is associated with an increased rate of adverse outcomes when compared with isolated ACL reconstruction (ACLR). The hypothesis was that there would be no significant difference between groups at a minimum follow-up of 1 year. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Recruitment commenced in November 2016. Patients scheduled for ACLR were randomized to either isolated ACLR (with bone–patellar tendon–bone [BPTB] autograft) or combined ACL + ALLR (with hamstring tendon autograft). All patients with a minimum follow-up of 1 year by March 2019 were included. The evaluated parameters included complications and reoperations, knee laxity parameters, range of motion, and scores on the Tegner, Lysholm, International Knee Documentation Committee (IKDC), and Knee injury and Osteoarthritis Outcome Score (KOOS) instruments. Results: A total of 224 patients (112 in each group) with a mean ± SD follow-up of 12.3 ± 1.9 months (range, 12-19 months) formed the study population. A significantly higher rate of reoperation for cyclops syndrome was noted in the isolated ACLR group compared with the combined ACL + ALLR group (8.9% vs 0%, respectively; P = .0012). No significant differences were found in frequency of graft rupture (ACLR, 5.4%; ACL + ALLR, 0.9%; P = .1191), range of motion deficits, pain, or reoperation for meniscectomy between groups. No cases of postoperative infection, venous thromboembolism, or arthrofibrosis were seen. Subjective IKDC (81.2 vs 86.8; P = .0048), Lysholm (88 vs 92; P = .0131), and some components of the KOOS were significantly better in the combined ACL + ALLR group. Conclusion: This study demonstrates no evidence of an increased risk of short-term adverse events after combined ACL + ALLR compared with isolated ACLR with BPTB graft. Registration: NCT03740022 ( ClinicalTrials.gov Identifier)
Selexipag treatment in patients with systemic sclerosis–associated pulmonary arterial hypertension in clinical practice, a case series
Authors: Lemmers Jacqueline MJ , Fretheim Håvard , Knaapen Hanneke KA , van den Hoogen Frank HJ , van Haren-Willems Jolanda HGM , Duijnhouwer Anthony L , van Dijk Arie P , van den Ende Cornelia HM , Hoffmann-Vold Anna-Maria , Vonk Madelon C 
Published: May 2020

Objective: To describe the efficacy and safety in all patients with systemic sclerosis–associated pulmonary arterial hypertension who started selexipag between 09-2016 and 06-2018 in two pulmonary arterial hypertension expert centers. Methods: All patients with systemic sclerosis–associated pulmonary arterial hypertension diagnosed by right heart catheterization and treated with selexipag were included. Every 12 weeks, treatment effect was assessed by (1) the opinion of the expert team and (2) the abbreviated risk assessment, consisting of functional class, six-minute walking distance, and N-terminal prohormone of brain natriuretic peptide level at baseline and during follow-up. Side effects and adverse events were registered. Results: We included 13 systemic sclerosis–associated pulmonary arterial hypertension patients, 10 patients were female, median age (interquartile range) of 68 (58–75) years, median systemic sclerosis disease duration of 7.4 (4.7–13.5) years, and median pulmonary arterial hypertension duration of 4 (2.5–7.5) years. Two patients discontinued selexipag within 4 weeks due to side effects. The remaining 11 patients had a median follow-up duration of 48 (interquartile range = 24–72) weeks. Two patients died (one pulmonary arterial hypertension–related, the other systemic sclerosis–related). According to the expert team, 8 of 11, 9 of 10, and 5 of 7 patients stabilized or improved at 12, 24, and 48 weeks, respectively. According to the abbreviated risk assessment at study end, 3 of 11 patients had 1 low-risk criterion. No previously unrecorded side effects were reported. Conclusion: Adding selexipag to background therapy in a high-risk cohort of systemic sclerosis–associated pulmonary arterial hypertension patients provided sustained stabilization of symptoms with an acceptable safety profile. Improvement was reached in only two of our patients. Further research should focus on systemic sclerosis–associated pulmonary arterial hypertension patients treated with multiple targeted treatments, preferably these patients should be prospectively followed in international registries.
Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect
Authors: Carvelli Julien , Piperoglou Christelle , Farnarier Catherine , Vely Frédéric , Mazodier Karin , Audonnet Sandra , Nitschke Patrick , Bole-Feysot Christine , Boucekine Mohamed , Cambon Audrey , Hamidou Mohamed , Harle Jean-Robert , de Saint Basile Geneviève , Kaplanski Gilles 
Published: May 2020

Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition. Primary HLH occurs early in life as a result of monogenic biallelic mutations affecting lymphocyte cytotoxicity. Secondary HLH occurs mostly in adults secondary to infection, lymphoma, or rheumatic disease. In this latter setting, lymphocyte cytotoxicity status is not known. We conducted a systematic evaluation of natural killer (NK) cell cytotoxicity in adult patients with secondary HLH. Adult patients with secondary HLH were prospectively studied ex vivo for total lymphocyte count and subtype, NK cell phenotype, perforin expression and degranulation, and natural or antibody-dependent cell cytotoxicity, in comparison with patients affected by the same underlying disease without HLH (disease controls [DCs]) and with healthy controls (HCs). Screening for variants of cytotoxity genes was systematically performed. 68 patients were included in the HLH group and 34 each in the DC and HC groups. In HLH patients, severe and transient lymphopenia, activated NK cell phenotype (eg, increased CD69, ICAM-1, HLADR, and CCR5 expression), and decreased capacity of interferon γ production were observed; mean perforin expression was normal; and degranulation tests and NK cell cytotoxicity were not different from those in DCs. A monoallelic variant of uncertain significance affecting a lymphocyte cytotoxicity gene or the perforin variant A91V was observed in almost 50% of the patients. We detected no major intrinsic cytotoxicity dysfunction in secondary HLH patients compared with DCs and no predicted pathogenic gene variant. The activated NK phenotype profile associated with decreased interferon γ production seems similar to those of other hyperinflammatory diseases such as sepsis or systemic juvenile idiopathic arthritis.
Running-In Behavior of Wet Multi-plate Clutches: Introduction of a New Test Method for Investigation and Characterization
Authors: Voelkel Katharina , Pflaum Hermann , Stahl Karsten 
Published: May 2020

AbstractWet multi-plate clutches are relevant components of modern drivetrain applications, not only in terms of function but also safety and comfort. Especially at the beginning of their lifetime, distinct changes of the friction behavior may occur and make the actuation of the clutch challenging. This transcript describes the typical running-in behavior of wet multi-plate clutches and gives a general definition for running-in of clutches. Moreover, a new test method to systematically investigate the running-in behavior of clutches is introduced. This test method contains a test procedure to characterize the running-in behavior on different load levels. Furthermore, a multi-stage procedure to evaluate and characterize the running-in behavior of clutches with mathematical approaches and new characteristic values is given. The quality of the test method is demonstrated on the example of three different tribological systems from dual clutch transmissions (DCT) and automatic transmissions (AT) application using paper friction linings.
Effect of Agitator’s Types on the Hydrodynamic Flow in an Agitated Tank
Authors: Foukrach Mohammed , Bouzit Mohamed , Ameur Houari , Kamla Youcef 
Published: May 2020

AbstractThe aim of this paper is to study the effect of agitator’s types on the turbulent flows in stirred tanks without and with baffles. The hydrodynamics behavior induced by four different agitator’s types: a Rushton turbine (RT), a circular blade turbine (CBT), a diverging triangular blade turbine (DTBT) and converging triangular blade turbine (CTBT) are numerically predicted by solving the Navier-Stokes equations and RNG κ–ε turbulent model. The simulations are carried out using the Multi Reference Frame (MRF) approach. The numerical results showed good agreement with experiment. We find that the agitator CTBT gives an important profit on the power consumption per report/ratio the others and DTBT give a good reduction of the vortex size of the impeller angles.
Influence of drying temperature on NO2 sorption ability of cedar timber
Authors: Nakagawa Miyuki , Umemura Kenji , Kawai Shuichi , Kanayama Kozo 
Published: May 2020

AbstractNO2 sorption ability of cedar (Cryptomeria japonica) timbers was evaluated using a new measuring system that was developed in our previous study. Four drying conditions were applied, namely natural drying and three kinds of kiln-drying at 45, 60, and 105 °C. Aeration experiments were conducted using discoid specimens which had a thickness in the longitudinal direction of 1.5 mm, and a diameter of 10 mm. The moisture content was conditioned to 0 or 9 ± 1.0% in each drying condition. As a result, the NO2 sorption ability declined as the drying temperature increased. Based on the analysis of extractives, it was shown that the extractives content had a high correlation with the contribution ratio of extractives in the NO2 sorption volume of the specimens that were dried below 60 °C. Therefore, it was elucidated that the specimen dried naturally has the greatest NO2 sorption ability. Furthermore, the result of the gas chromatography–mass spectrometry (GC/MS) indicated that abietadiene influenced the NO2 sorption ability. Also, the NO2 sorption volume was high especially at the initial stage, which is higher under the condition with moisture.
User rating and acceptance of attention-adaptive driver safety systems
Authors: Weber Betina , Dangelmaier Manfred , Diederichs Frederik , Spath Dieter 
Published: May 2020

AbstractCurrent statistics show that distraction is a central cause of traffic accidents. Safety systems with distance control currently available on the market have great potential for preventing accidents and significantly reducing their severity. However, depending on the driver’s level of attention, the systems warn too early or too late, which impairs use acceptance. Adaptive systems allow for personalization according to driver’s attention level. Studies were carried out in a driving simulator in order to compare the system adaptations with regard to acceptance for attentive and distracted driving phases. Seventy-two participants took part in the study, with a between-subjects test design. Acceptance ratings shows highest acceptability for the adaptive systems in distractive situations. We conclude that personalization of attention-adaptive systems shall be implemented in case safety benefits are proven.
wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data
Authors: Wöste Marius , Leitão Elsa , Laurentino Sandra , Horsthemke Bernhard , Rahmann Sven , Schröder Christopher 
Published: May 2020

AbstractBackgroundAnalysing whole genome bisulfite sequencing datasets is a data-intensive task that requires comprehensive and reproducible workflows to generate valid results. While many algorithms have been developed for tasks such as alignment, comprehensive end-to-end pipelines are still sparse. Furthermore, previous pipelines lack features or show technical deficiencies, thus impeding analyses.ResultsWe developed wg-blimp (wholegenomebisulfite sequencingmethylation analysispipeline) as an end-to-end pipeline to ease whole genome bisulfite sequencing data analysis. It integrates established algorithms for alignment, quality control, methylation calling, detection of differentially methylated regions, and methylome segmentation, requiring only a reference genome and raw sequencing data as input. Comparing wg-blimp to previous end-to-end pipelines reveals similar setups for common sequence processing tasks, but shows differences for post-alignment analyses. We improve on previous pipelines by providing a more comprehensive analysis workflow as well as an interactive user interface. To demonstrate wg-blimp’s ability to produce correct results we used it to call differentially methylated regions for two publicly available datasets. We were able to replicate 112 of 114 previously published regions, and found results to be consistent with previous findings. We further applied wg-blimp to a publicly available sample of embryonic stem cells to showcase methylome segmentation. As expected, unmethylated regions were in close proximity of transcription start sites. Segmentation results were consistent with previous analyses, despite different reference genomes and sequencing techniques.Conclusionswg-blimp provides a comprehensive analysis pipeline for whole genome bisulfite sequencing data as well as a user interface for simplified result inspection. We demonstrated its applicability by analysing multiple publicly available datasets. Thus, wg-blimp is a relevant alternative to previous analysis pipelines and may facilitate future epigenetic research.
Shedding light: a phylotranscriptomic perspective illuminates the origin of photosymbiosis in marine bivalves
Authors: Li Jingchun , Lemer Sarah , Kirkendale Lisa , Bieler Rüdiger , Cavanaugh Colleen , Giribet Gonzalo 
Published: May 2020

AbstractBackgroundPhotosymbiotic associations between metazoan hosts and photosynthetic dinoflagellates are crucial to the trophic and structural integrity of many marine ecosystems, including coral reefs. Although extensive efforts have been devoted to study the short-term ecological interactions between coral hosts and their symbionts, long-term evolutionary dynamics of photosymbiosis in many marine animals are not well understood. Within Bivalvia, the second largest class of mollusks, obligate photosymbiosis is found in two marine lineages: the giant clams (subfamily Tridacninae) and the heart cockles (subfamily Fraginae), both in the family Cardiidae. Morphologically, giant clams show relatively conservative shell forms whereas photosymbiotic fragines exhibit a diverse suite of anatomical adaptations including flattened shells, leafy mantle extensions, and lens-like microstructural structures. To date, the phylogenetic relationships between these two subfamilies remain poorly resolved, and it is unclear whether photosymbiosis in cardiids originated once or twice.ResultsIn this study, we establish a backbone phylogeny for Cardiidae utilizing RNASeq-based transcriptomic data from Tridacninae, Fraginae and other cardiids. A variety of phylogenomic approaches were used to infer the relationship between the two groups. Our analyses found conflicting gene signals and potential rapid divergence among the lineages. Overall, results support a sister group relationship between Tridacninae and Fraginae, which diverged during the Cretaceous. Although a sister group relationship is recovered, ancestral state reconstruction using maximum likelihood-based methods reveals two independent origins of photosymbiosis, one at the base of Tridacninae and the other within a symbiotic Fraginae clade.ConclusionsThe newly revealed common ancestry between Tridacninae and Fraginae brings a possibility that certain genetic, metabolic, and/or anatomical exaptations existed in their last common ancestor, which promoted both lineages to independently establish photosymbiosis, possibly in response to the modern expansion of reef habitats.