bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic transhiatal suture closure for spontaneous esophageal rupture: a case report
Authors: Hayakawa Shunsuke , Mitsui Akira , Kato Yuko , Morimoto Shota , Watanabe Kaori , Shamoto Tomonari , Wakasugi Takehiro , Kuwabara Yoshiyuki 
Published: October 2019

Abstract

Background
Spontaneous esophageal rupture is a rare but serious disease with high mortality. Conservative treatment and endoscopic therapy have been reported, but surgical treatment is still a basic modality of therapy. In addition to thoracotomy, recent studies have reported treatment with thoracoscopic surgery and laparoscopic transhiatal repair. In this study, we report a patient who underwent laparoscopic transhiatal suture closure for spontaneous esophageal rupture with favorable postoperative course. We also discuss indication for laparoscopic surgery for spontaneous esophageal rupture.

Case presentation
A 70-year-old man visited our hospital with chief complaints of epigastric pain and vomitus niger. He was diagnosed with spontaneous esophageal rupture in the left wall of the lower esophagus by computed tomography and upper gastrointestinal (GI) series. At 11 h after the onset of symptoms, we performed laparoscopic transhiatal suture closure and lavage drainage. We performed transhiatal esophageal replacement using the 5-hole approach. We observed a perforation of 2 cm in diameter at the site of the rostral portion approximately 4 cm from the esophageal hiatus. All layers were closed with three stitches using 3–0 absorbable sutures. No perforation was observed in the thoracic cavity. The total operative time was 178 min, and total bleeding was 2 ml. He had no postoperative complications and was discharged on day 15 after the procedure. He received continuous proton pump inhibitor therapy as an outpatient. Healing cicatrization was found at the site of rupture by esophagogastroscopy. The patient was advised to improve his lifestyle and has shown no signs of recurrence over 2 years from the date of surgery.

Conclusions
Simple closure of all the layers using laparoscopic transhiatal simple closure was useful in the treatment of esophageal rupture as a less invasive approach for patients who meet the following conditions: stable general condition, intrathoracic perforation, and the perforation site is identified as the lower esophagus by pre-operative examination.
Divergent Metastatic Patterns Between Subtypes of Thyroid Carcinoma Results From the Nationwide Dutch Pathology Registry
Authors: Hugen Niek , Sloot Yvette J E , Netea-Maier Romana T , van de Water Carlijn , Smit Jan W A , Nagtegaal Iris D , van Engen-van Grunsven Ilse C H 
Published: October 2019

Abstract

Background
Metastatic disease is the main cause of cancer-related mortality in thyroid carcinoma (TC) patients. Clinical studies have suggested differences in metastatic patterns between the different subtypes of TC. This study systematically evaluates the metastatic patterns of different subtypes in TC patients.

Methods
A nationwide review of pathological records of all 650 patients diagnosed with a primary malignancy in the thyroid who underwent an autopsy between 1991 and 2010 was performed. Patients were selected from the Dutch pathology registry (PALGA).

Results
Metastatic disease was present in 228 (35.1%) patients and was found in 38.7%, 17.3%, 75.4%, and 47.8% of patients with follicular, papillary, anaplastic, and medullary types of TC, respectively (P &lt; .0001). The majority of patients had more than 1 metastasis. The most common site of metastatic disease was the lung for papillary (79.7%), follicular (72.9%), and anaplastic (92.1%) carcinoma but not for medullary carcinoma (56.3%), P &lt; .0001. Medullary carcinoma patients most frequently had metastases to the liver (81.3%). The combination of metastases also differed between subtypes.

Conclusion
There are major differences in metastatic patterns between different subtypes of TC. The patterns and frequencies identified in this autopsy study may reflect the underlying biology of metastatic thyroid cancer and have potential to influence future monitoring and treatment strategies depending on clinical correlations.
Adjuvant Hepatic Arterial Infusion Pump Chemotherapy After Resection of Colorectal Liver Metastases: Results of a Safety and Feasibility Study in The Netherlands
Authors: Buisman Florian E. , Grünhagen Dirk J. , Homs Marjolein Y. V. , Grootscholten Cecile , Filipe Wills F. , Kemeny Nancy E. , Cercek Andrea , D’Angelica Micheal I. , Donswijk Maarten L. , van Doorn Leni , Emmering Jasper , Jarnagin William R. , Kingham T. Peter , Klompenhouwer Elisabeth G. , Kok Niels F. M. , Kuiper Maria C. , Moelker Adriaan , Prevoo Warner , Versleijen Michelle W. J. , Verhoef Cornelis , Kuhlmann Koert F. D. , Groot Koerkamp Bas 
Published: October 2019

Abstract

Background
The 10-year overall survival with adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after resection of colorectal liver metastases (CRLMs) was 61% in clinical trials from Memorial Sloan Kettering Cancer Center. A pilot study was performed to evaluate the safety and feasibility of adjuvant HAIP chemotherapy in patients with resectable CRLMs.

Study Design
A phase II study was performed in two centers in The Netherlands. Patients with resectable CRLM without extrahepatic disease were eligible. All patients underwent complete resection and/or ablation of CRLMs and pump implantation. Safety was determined by the 90-day HAIP-related postoperative complications from the day of pump placement (Clavien–Dindo classification, grade III or higher) and feasibility by the successful administration of the first cycle of HAIP chemotherapy.

Results
A total of 20 patients, with a median age of 57 years (interquartile range [IQR] 51–64) were included. Grade III or higher HAIP-related postoperative complications were found in two patients (10%), both of whom had a reoperation (without laparotomy) to replace a pump with a slow flow rate or to reposition a flipped pump. No arterial bleeding, arterial dissection, arterial thrombosis, extrahepatic perfusion, pump pocket hematoma, or pump pocket infections were found within 90 days after surgery. After a median of 43 days (IQR 29–52) following surgery, all patients received the first dose of HAIP chemotherapy, which was completed uneventfully in all patients.

Conclusion
Pump implantation is safe, and administration of HAIP chemotherapy is feasible, in patients with resectable CRLMs, after training of a dedicated multidisciplinary team.
Implementation of a modified quality assurance protocol for CBCT machines within UT health San Antonio School of Dentistry
Authors: Shahbazi Moghaddam Arezou , Kats Joshua C , Katkar Rujuta , Diogenes Anibal R , Yeh Chih-Ko , Deahl S. Thomas 
Published: October 2019

Objectives: To implement the quality control assurance protocol (including the re-establishment of baseline data from 2016) to monitor the stability of image quality of CBCT machines located within the UT Health San Antonio School of Dentistry. Methods and materials: Five CBCT machines ProMax 3D Mid® (Planmeca Oy, Helsinki, Finland), 3D Accuitomo XYZ Slice View Tomograph® (Model MCT-1, Type EX-1F8; Fushimi-ku, Kyoto: J. Morita Mfg. Corp), Veraviewepocs 3D (Model R100; Fushimi-ku, Kyoto: J. Morita Mfg. Corp), PreXion3D Excelsior® (PreXion, San Mateo, CA), and i-CAT FLX Series® (Imaging Sciences International, Hatfield, PA) were tested for Artifact, Contrast-to-Noise Ratio, Noise, Spatial Resolution, and Contrast Resolution using a custom insert configuration in the SEDENTEXCT IQ phantom. Results: Four-scan benchmark mean values for Artifact, Contrast-to-Noise, Noise, Spatial Resolution, and Contrast Resolution were determined for the five machines tested with associated alert and action level thresholds calculated. Conclusion: This newly developed QA protocol established image quality baseline values. Recommended tests, frequency, and actions levels have been updated and control charts established for future trend analysis to enable proper implementation of a QA protocol monitoring CBCT machines at UT health San Antonio.
Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta
Authors: Wang Lingyan , Hou Jiayun , Shi Lin 
Published: October 2019

Abstract: Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the antitumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.
Assessment of efficacy of trastuzumab (Herceptin) comprising adjuvant therapy of HER2+ breast cancer patients determined based upon statistical analysis of overall survival (OS) and disease-free survival (PFS)
Authors: Jagielska Beata , Czubek Andrzej , Talasiewicz Konrad , Twarowski Adam , Rutkowski Piotr , Krzakowski Maciej , Saetre Bianka , Malecki Marek 
Published: October 2019

Abstract: In patients suffering from breast cancer, adjuvant radiation, chemotherapy, or immunotherapy, which immediately follow the surgery as the first line therapy, greatly improve overall (OS) and disease-free survival (DFS). Various regimens of adjuvant therapy for these patients have been tested contingent upon the clinical staging. Inclusion of adjuvant immunotherapy is particularly promising.
Comparative Analysis of Biochemical Biases by Ligation- and Template-Switch-Based Small RNA Library Preparation Protocols
Authors: Meistertzheim Morgane , Fehlmann Tobias , Drews Franziska , Pirritano Marcello , Gasparoni Gilles , Keller Andreas , Simon Martin 
Published: October 2019

AbstractBACKGROUNDSmall RNAs are key players in the regulation of gene expression and differentiation. However, many different classes of small RNAs (sRNAs) have been described with distinct biogenesis pathways and, as a result, with different biochemical properties. To analyze sRNAs by deep sequencing, complementary DNA synthesis requires manipulation of the RNA molecule itself. Thus, enzymatic activities during library preparation bias the library content owing to biochemical criteria.METHODSWe compared 4 different manipulations of RNA for library preparation: (a) a ligation-based procedure allowing only 5′-mono-phosphorylated RNA to enter the library, (b) a ligation-based procedure allowing additional 5′-triphosphates and Cap structures, (c) a ligation-independent, template-switch-based library preparation, and (d) a template-switch-based library preparation allowing 3′-phosphorylated RNAs to enter the library.RESULTSOur data show large differences between ligation-dependent and ligation-independent libraries in terms of their preference for individual sRNA classes such as microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs), and transfer RNA fragments. Moreover, the miRNA composition is different between both procedures, and more microRNA isoforms (isomiRs) can be identified after pyrophosphatase treatment. piRNAs are enriched in template-switch libraries, and this procedure apparently includes more different RNA species.CONCLUSIONSOur data indicate that miRNAomics from both methods will hardly be comparable. Ligation-based libraries enrich for canonical miRNAs, which thus may be suitable methods for miRNAomics. Template-switch libraries contain increased numbers and different compositions of fragments and long RNAs. Following different interests for other small RNA species, ligation-independent libraries appear to show a more realistic sRNA landscape with lower bias against biochemical modifications.
The place of aceclofenac in the preparation of patients with rheumatic diseases for joint surgery
Authors: Amirdzhanova V. N. , Karateev A. E. 
Published: October 2019

To identify risk factors for gastrointestinal, cardiovascular, and thrombotic complications, as well as postoperative bleeding, by individually choosing analgesic anti-inflammatory therapy, including that with nonsteroidal anti-inflammatory drugs, is the most important task in the preoperative preparation of patients with rheumatic inflammatory joint diseases.The paper reviews studies evaluating the efficiency and safety of long-term aceclofenac use in patients who are to undergo joint surgery.
Vagueness of Language: Indeterminacy under Two-Dimensional State-Uncertainty
Authors: Chiba Saori 
Published: October 2019

AbstractWe studyindeterminacy of indicative meanings(disagreements about meanings of messages among players), a kind of language vagueness examined in Blume and Board (2013. “Language Barriers.”Econometrica81 (2): 781–812). They, using a cheap talk model in which the state-distribution and the players’ language competence were ex-ante uncertain, demonstrated that this vagueness occurs as an equilibrium language. We expand the work of Blume and Board by using a model between an uninformed decision maker and an informed agent in which the state-distribution and the state are both ex-ante uncertain. We show that this two-dimensional uncertainty also leads to indeterminacy of indicative meanings, that is, to a set of conditions in which an agent with different perceptions of the state-distribution intentionally uses the same symbol for the different extents of information on the state. The vagueness, contrary to common expectations, can actually lead to welfare improvement.
The crystal structure of poly[(μ3-2,4,6-tris[4-(1H-imidazol-1-yl)phenyl]-1,3,5-triazine-k3N:N′:N′′)-(nitrato-k2O,O)-(nitrato-k1O)zinc(II)] - N,N-dimethylacetamide (1/2), C38H39N13O8Zn
Authors: Cui Hao , Qiu Si-Si , Yang Tao 
Published: October 2019

Abstract
C38H39N13O8Zn, monoclinic, P21/c (no. 14), a = 13.0155(7) Å, b = 32.7011(14) Å, c = 9.8464(4) Å, β = 110.228(1)°, V = 3932.4(3) Å3, Z = 4, R
gt(F) = 0.0476, wR
ref(F
2) = 0.1358, T = 150(2) K.
Efectos de la suplementación con bloques multinutricionales a base de nopal fermentado sobre la ganancia de peso de ovinos en crecimiento
Authors: Mejía Haro José , Delgado Hernández José Luis , Mejía Haro Ignacio , Guajardo Hernández Isidro , Valencia Posadas Mauricio 
Published: October 2019

Este trabajo presenta una alternativa práctica del aprovechamiento del nopal mediante la elaboración de Bloques Multinutricionales (BM) y su utilización en la alimentación de corderos en crecimiento. Al nopal fresco picado se le adicionó sorgo, soya, urea, minerales y yogurt natural, se dejó fermentar por dos semanas a temperatura ambiente y se elaboraron los BM con un 25 % de nopal fermentado. Se utilizaron 20 corderos destetados con un peso vivo promedio de 17 Kg distribuidos en dos grupos (con y sin BM), ambos grupos recibieron una dieta típica. Durante 57 días de experimentación se midió el consumo de alimento, consumo de BM y el peso de los corderos. Los pesos de los animales fueron analizados estadísticamente mediante un análisis de varianza con un diseño completamente al azar. No se encontraron diferencias estadísticamente significativas (P > .05) en los pesos de los animales. El BM elaborado con nopal fermentado fue consumido adecuadamente por los animales.
Petrografía y distribución de óxidos de Fe, Al y Si en fragipanes blancos de origen volcánico
Authors: Acevedo-Sandoval Otilio Arturo , Prieto-Mendez Judith , Vela-Correa Gilberto , Ortiz-Hernández Enrique , Prieto-García Francisco 
Published: October 2019

El objetivo fue determinar la petrología y distribución de óxidos de Fe, Al y Si en tres perfiles de suelos de origen volcánico con horizontes endurecidos (fragipán), en la región noroeste del Estado de México. Se utilizaron técnicas químicas selectivas para extraer Fe, Al y Si. El fragipán blanco clasifica petrográficamente como toba dacítica poco soldada y alterada. Los perfiles muestran incipiente a moderado grado de alteración de minerales primarios que contienen Fe y Al dadas las condiciones climáticas de la región. Los contenidos de alofano, ferrihidrita, y óxidos de hierro cristalino se presentan en pocas cantidades, escasos contenidos de Ald y Si lábil en los perfiles indican presencia de aluminosilicatos cristalinos. Bajas relaciones de Alp/Alo y Fep/Feo evidencia que la mayor parte de Al y Fe están unidos a compuestos inorgánicos pobremente cristalinos. Relaciones bajas de Fep/Fed y Alp/Ald indican limitada asociación de Fe y Al con compuestos orgánicos. La relación arcilla/Fed revela emigración de arcilla y óxidos de Fe del horizonte superior al fragipán. El Si, Al y Fe en el fragipán forman parte de la estructura de los silicatos y mínimo grado de cristalinidad de Fe y Al pedogenético. Valores mayores de relación Sid(Sid+Ald) en el fragipán indican aumento en la dureza.
Celdas solares orgánicas como fuente de energía sustentable
Authors: Barbosa García Oracio , Maldonado José Luis , Ramos Ortíz Gabriel , Rodríguez Mario , Pérez Gutiérrez Enrique , Meneses Nava Marco A. , Pichardo Juan Luis , Ornelas Nancy , López de Alba Pedro Luis 
Published: October 2019

Las celdas solares inorgánicas han mostrado un gran desarrollo, sin embargo el alto costo de producción ha imposibilitado su amplio uso. Por otro lado, el empleo de materiales orgánicos en la fabricación de celdas es una alternativa actualmente considerada por diversos grupos de investigación a nivel mundial. Los retos principales para las celdas orgánicas son el incremento de la eficiencia de conversión de energía solar en eléctrica, la reducción en sus costos de fabricación y el alcanzar un mayor tiempo de vida. Para lograr estos factores los grupos de investigación trabajan de forma interdisciplinaria sintetizando/modificando nuevos materiales orgánicos y desarrollando nuevas configuraciones. Las fuentes principales de energía en los siglos anteriores fueron mayormente no renovables mientras que las celdas solares orgánicas son fuentes de energía renovables. En este artículo se presenta una introducción general en este campo de investigación señalando las contribuciones realizadas por el grupo de Propiedades Ópticas de la Materia del Centro de Investigaciones en Óptica.
Algunos elementos sobre sexualidad en pobladores de un área rural del estado Cojedes, Venezuela.
Authors: Gámez Ligia , Artega Everilda , Bastidas Gilberto 
Published: October 2019

El conocimiento de temas relacionados con la salud sexual y reproductiva evidencia vacíos en los países latinoamericanos en cuanto a reproducción, especialmente en el medio rural y en personas con menor nivel educativo. Se pretende con esta investigación describir características de la sexualidad en el área rural, primer estudio en Venezuela. Estudio descriptivo, transversal y de campo, con un cuestionario como instrumento, la muestra fue de 128 individuos de la comunidad de Apamates, Cojedes. La edad promedio fue 25,3 años, resultaron solteros 76,5% de los hombres y 43,6% de las mujeres. 96,1% de las personas saben leer y escribir pero únicamente 19,5% tenían bachillerato completo. 35,9% eran obreros y 82,8% recibían sueldo básico. 82% conocen los métodos anticonceptivos. El condón y los anticonceptivos orales son los mayormente usados. Fue baja la prevalencia de ITS. La mayoría tenía entre 0 y 1 hijo. Los hombres por iniciativa propia buscan información sobre sexualidad. El conocimiento sobre sexualidad en ambos géneros es bajo. Ambos géneros mantienen relaciones sexuales por amor y con fines reproductivos. Desconocen que es el orgasmo. Se concluye que: desconocen aspectos básicos sobre la sexualidad y reproducción; la sexualidad es un tabú; y conocen los anticonceptivos pero no los usa con frecuencia. Para el desarrollo de la sexualidad es indispensable tener educación sexual verdaderamente eficaz.
Spectrum of bacterial infections and predictors of mortality in adult cirrhotic patients
Authors: Kudru Chandrashekar Udyavara , Kalwaje Eshwara Vandana , Nagiri Shivashankara Kaniyoor , Guddattu Vasudeva 
Published: October 2019

Introduction. Bacterial infections are more frequent in patients with decompensated cirrhosis than those with compensated liver disease and account for significant morbidity and mortality in them. Once an infection develops, it induces excessive production of pro-inflammatory cytokines leading to organ failure and death.
Aims. This study aims to identify the clinical characteristics and outcome of bacterial infections affecting various organ systems in patients with liver cirrhosis and to determine factors associated with mortality.
Materials and methods. A cross sectional study was performed on subjects with cirrhosis having microbiologically proven bacterial infection involving various organ systems, admitted to a tertiary care hospital in southern India. Demographic, clinical data, laboratory parameters and outcome details were noted. Univariate associations and subsequent multivariate logistic regression analysis was performed to determine factors associated with mortality.
Results. The study included 158 patients. Chronic alcohol intake was the most common etiology of cirrhosis (66.4%). Community acquired infections occurred more frequently than hospital acquired infections (85.5% vs 14.5%). The common site of isolation of etiological agent was ascitic fluid (38.3%) followed by blood (24.3%), respiratory tract (15.5%) and urinary tract (14.5%). Gram negative bacterial infections were more common (74.3%), Escherichia coli being the most frequent pathogen (38.5%). Mortality was noted in 38 (24%) patients. The factors associated with mortality were the type of infection, Child Pugh category, acute kidney injury, hepatic encephalopathy, urinary tract infection, and creatinine and bilirubin levels. Multivariate logistic regression analysis revealed that type of infection (OR: 0.33, 95% CI: 0.11-1.01), ascitic fluid infection (OR: 2.81, 95% CI: 1.11-7.12), hepatic encephalopathy (OR: 0.17, 95% CI: 0.070-0.422) and acute kidney injury (OR: 0.19, 95% CI: 0.077-0.502) were significantly associated with in-hospital mortality.
Conclusion. This study indicates that the type of infection, hepatic encephalopathy, ascitic fluid infection and acute kidney injury are associated with mortality in cirrhotic patients. Early effective treatment and prevention of these complications may help modify the outcome.