bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plastic Drape and Copper Frame For Airway Management in the COVID-19 Era: A Case Series
Authors: Mainville Darcy J. , Hou Borin , Chrissian Ara A. , Giri Paresh C. , Chang Melody M. , Turay David , Shipley Desara , Markovich Susan , Scott Loreen K. , Smith Dustin D. , Dorotta Ihab R. , Nguyen H. Bryant , Mukherjee Kaushik 
Published: November 2020

Abstract
Purpose: Airway manipulation is a high-risk procedure due to aerosolization of viral particles. This has become of paramount importance during the COVID-19 pandemic in an effort to protect personnel involved in airway management. We designed and tested a copper frame to support a plastic drape to contain aerosols and allow for reduction of risk during airway management. The “CopperHead” frame allows airway management with minimal limitations in a wide range of scenarios including elective and urgent intubations, management of unstable patients, cardiopulmonary resuscitation (CPR), bronchoscopy, and extubation. The frame was made of copper to utilize its inherent antimicrobial and antiviral properties. Intervention and Measurements: We performed multiple simulations to measure FiO2 accumulation underneath the frame and plastic drape. We also performed defibrillations on a mannequin with the apparatus in place to evaluate for safety during times that the device is not removed prior to defibrillation, as indicated. We then deployed the device throughout our hospital and analyzed the resulting data on procedure success and infection rates in both COVID-positive and COVID-negative cohorts.Main Results: The technique is reproducible and allows for airway manipulation in COVID-19 suspected or confirmed patients. The FiO2 under the copper frame and plastic drape increased, but quickly dispersed when the frame was removed. We performed multiple defibrillations with apparatus in place with no adverse events. We showed that with the device in place, there appears to be no hindrance to successful intubation with 94 successful procedures in 74 patients and an 87% (60/69) first-pass intubation rate, and there were no documented clinicians or respiratory therapy infections through exposures to COVID-19 positive patients.Conclusions: The addition of a copper frame to a plastic drape over patients was an effective way to improve the safety and ease of intubation in the COVID-19 pandemic. This device was well received among our clinicians and served to benefit both intubation and extubation of recovered patients.
Oxytocin Discontinuation During Induced Labor in Pregnancies With Suspected Fetal Growth Restriction
Authors: Iwai Sayuri , Mimura Kazuya , Endo Masayuki , Kawanishi Yoko , Kakigano Aiko , Miyake Tatsuya , Matsuzaki Shinya , Tomimatsu Takuji , Kimura Tadashi 
Published: November 2020

Abstract
Objective: Although fetal growth restriction (FGR) is associated with an increased risk of cesarean delivery during induced labor, there is little evidence to guide labor management in such cases. This study aimed to investigate whether discontinuation of oxytocin infusion affects the cesarean delivery rate and the risk of maternal and neonatal complications associated with induced labor in pregnancies with suspected FGR.Methods: This was a retrospective cohort study of singleton pregnancies with vertex presentation and indications for labor induction due to FGR after 34.0 weeks of gestation at our institution from January 2010 to December 2017. Two parallel groups were compared: women who received oxytocin continuously until delivery (continuation group) and women whose oxytocin was discontinued at the beginning of the active phase of labor (discontinuation group).Results: There were 74 women in the continuation group and 51 women in the discontinuation group. The incidence of cesarean deliveries was higher (5.4% vs 2.0%) in the continuation group, but this difference was not statistically significant. However, the incidence of uterine tachysystole (23.0% vs 9.8%) was significantly higher in the continuation group than in the discontinuation group. Differences in labor management did not affect the lengths of the active phase and second stage of labor (mean, 136 ± 122 minutes and 34.2 ± 45 minutes, respectively; 122 ± 104 minutes and 48.8±67 minutes in the continuation group and discontinuation group, respectively). The incidence of postpartum hemorrhage and adverse neonatal outcomes were not significantly different between groups.Conclusions: Oxytocin can be safely discontinued after the active phase of labor in women undergoing labor induction for FGR without an increased risk of cesarean delivery or other unfavorable outcomes. Therefore, this strategy may be considered an alternative to continued oxytocin infusion.
Anais I COMFER - Congresso Médico de Fernandópolis - Universidade Brasil
Authors: Rodero Ademir Barianni , Lima Alba Regina Abreu , Lozano André Willian , Miyamoto Janine Hatsumi , Souza José Antônio Santa , Pinto Neto José Martins , Simonato Luciana Estevam , Antônio Luiz Gustavo Madi , Gaggini Márcio Cesar Reino 
Published: November 2020

Editorial
Caro(a) Leitor(a),
O Curso de Medicina da Universidade Brasil – Campus Fernandópolis vivenciará, no período de 02 a 05 de março de 2020, a I Congresso Médico de Fernandópolis (I COMFER).
O nosso Congresso traz em sua Grade Científica uma abordagem do mais alto nível, apresentando palestras ministradas por profissionais da área médica do mais alto renome, além dos trabalhos, para apresentação painel, nas modalidades Pesquisa Científica, Caso Clínico, Revisão de Literatura e Projeto de Extensão Universitária.
As palestras, serão ministradas por renomados expoentes da Medicina, sempre embasados no que há de mais atual em termos de pesquisa científica. Serão abordados temas relevantes sobre saúde voltados para a prática clínica, transmitindo e gerando conhecimentos aos participantes deste evento e, desta forma, atingindo e proporcionando benefícios à população.
Peço que todos os participantes deste evento façam uma reflexão sobre a responsabilidade social do médico no que diz respeito à sua atuação para a melhoria da qualidade de vida da sociedade brasileira, valorizando a saúde em geral, celebrando, desta forma, a vida no seu sentido mais amplo.
Convido todos vocês para que desfrutem deste momento, esperando que aproveitem ao máximo os ensinamentos que serão transmitidos. Lembro-os que neste mundo globalizado e competitivo não há como crescer profissionalmente sem agregar novos conhecimentos. Todos os dias!!!
Obrigado, sejam bem vindos,

Lucas Osmar Mariano
Presidente Discente do I Congresso Médico de Fernandópolis - Curso de Medicina da Universidade Brasil – Campus Fernandópolis - 2020
Overview of Selected Natural Gas Drying Methods
Authors: GENEROWICZ Natalia 
Published: November 2020

Abstract
The gas produced from the deposit usually contains various types of pollution. They are the reason for limiting its use, often making its use impossible. Therefore, it requires appropriate treatment. One of the main pollutants in gas is water. Its occurrence causes a lot of problems, especially at the stage of gas transport, such as the formation of hydrates blocking pipelines and apparatus, causes the phenomenon of condensation and corrosion of pipelines, especially if there is carbon dioxide or hydrogen sulphide in the gas. The paper presents a number of methods that enable drying of gas after extraction. Each of them has different parameters that will be achieved for the gas after it is dried. Depending on the required degree of drying, the economics of the process and compatibility with other dependent processes, the individual methods are more or less used in gas engineering. The paper discusses methods of absorption in ethylene glycol solutions, adsorption methods using silica gel, molecular sieves or calcium chloride and low-temperature processes such as Twister® supersonic separator, IFPEX-1® process and DexProTM process.
Saberes e Modos de Vida: por um Projeto Coletivo de Turismo de Base Comunitária na Comunidade Ribeirinha São Gonçalo Beira Rio, Mato Grosso, Brasil
Authors: Alcântara Liliane Cristine Schlemer , Duarte Ana Paula Pereira 
Published: November 2020

Frente a crise socioeconômica e ambiental, o Turismo de Base Comunitária (TBC) representa uma alternativa ao desenvolvimento que tem como escopo conservar os recursos naturais, promovendo o bem-estar das comunidades por meio da geração de renda e inclusão social. O objetivo deste estudo está em investigar os principais desafios e possibilidades para o desenvolvimento do turismo de base comunitária na comunidade ribeirinha São Gonçalo Beira Rio, marco da fundação do município de Cuiabá-MT. Metodologicamente optou-se pela pesquisa de campo; como ferramenta de análise situacional, a matriz de Swot e a análise dos dados foram concatenados com o discurso de Foucault. Os resultados preliminares evidenciam que a localidade de São Gonçalo Beira Rio apresenta possibilidades para o desenvolvimento do TBC, frente a riqueza de saberes e dos seus modos de vida desta comunidade. Porém, em função da complexidade e das inúmeras variáveis identificadas, será necessário um planejamento coletivo, iniciando-se pela sensibilização, mobilização e qualificação dos atores envolvidos, bem como adoção de estratégias comunitárias a fim de auferir melhores resultados.
Removal of Cd(II) from water using zero valent iron/copper functionalized spent tea
Authors: Malook Khan , Khan Hamayun 
Published: November 2020

Abstract
Zero valent Fe/Cu functionalized spent tea adsorbent was prepared for the decontamination of Cd(II) contaminated water. The synthesized material was characterized for structural and morphological characteristics using various analytical techniques. The material was used as adsorbent for the adsorption of Cd(II) from aqueous solutions in batch study experiments. The effect of initial pH, adsorbent dosage, contact time and adsorbate concentration was investigated. The obtained data well followed the Langmuir adsorption isotherm model and pseudo-second order rate model with maximum adsorption capacity of 89.686 mg·g−1. Based on Langmuir separation factor (R), having a value of 0.706–0.194, the adsorption process was confirmed to be favorable. The adsorbent was used in the form of a column for the sorption of Cd(II) from a running solution with satisfactory results. The spent material was regenerated and reutilized with reduction of adsorption capacity by 1.48% only. Overall, the current adsorbent can be efficiently utilized for the removal of aqueous Cd(II).
Development and Validation of a LC-MS/MS Method for Quantification of Mobocertinib (TAK-788) in Plasma and its Application to Pharmacokinetic Study in Rats
Authors: Li Bo , Wang Jin , Dou Xinyao , Zhang Xinjie , Xue Xianbei , Xu Qiao , Ran Wenwen , Xiong Shan 
Published: November 2020

Aim and Objective:
An analytical method for the determination of mobocertinib, an investigational tyrosine kinase inhibitor, was
developed and optimized by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma.

Materials and Methods:
Plasma samples were pretreated by the protein precipitation method with a methanol solution of osimertinib as the
internal standard (IS). Chromatographic separation was performed using an Inertsil ODS-3 column (50 mm × 4.6 mm, I.D. 5 μm) column
with the temperature maintained at 40 °C. The mobile phase consisted of water (containing 0.1% formic acid) and methanol in a gradient
mode at a flow rate of 0.5 mL/min. Mass spectrometric detection was carried out in the selected reaction monitoring (SRM) mode with positive
electrospray ionization, and the mass transitions of mobocertinib and osimertinib were m/z 587.01 → 71.88 and m/z 499.80 → 71.94,
respectively. The method was validated in terms of selectivity, linearity, accuracy and precision, extraction recovery and matrix effect, stability
and carryover as per the guidelines for bioanalytical method validation (FDA, 2018). The method was applied to the pharmacokinetic
study of mobocertinib in rats by oral gavage at the doses of 2, 6, and 18 mg/kg. A total of 216 plasma samples from 18 rats were analyzed.

Results:
It showed good linearity over the range of 1-1000 ng/mL (R2 = 0.9957). The intra-batch accuracy was within 94.65-102.59% and
the precision was within 5.49-10.46%. The inter-batch accuracy was within 97.08-102.25% with a precision of 7.54-10.13%. The extraction
recovery and matrix factor were acceptable for the bioanalysis of mobocertinib. Additionally, mobocertinib was found to be stable under the
detected conditions. Mobocertinib showed linear pharmacokinetic characteristics following oral administration to rats at 2.0-18.0 mg/kg.

Conclusion:
The developed and validated method was successfully employed in the pharmacokinetic study in rats following oral administration
of mobocertinib at the doses of 2, 6, and 18 mg/kg.
Development and Optimization of Inhalable Levofloxacin Nanoparticles for The Treatment of Tuberculosis
Authors: Shah Sunny , Ghetiya Rohit , Soniwala Moinuddin , Chavda Jayant 
Published: November 2020

Background:
Levofloxacin has been recommended by WHO for the treatment of pulmonary tuberculosis and inhalable
delivery of levofloxacin can be advantageous over conventional delivery.

Objective:
This study aimed to develop and optimize inhalable levofloxacin loaded chitosan nanoparticles (LCN). The objective
was to achieve the mean particle size of LCN less than 300nm, sustain the drug release up to 24 h and achieve
MMAD of LCN of less than 5μm.

Methods:
LCN were prepared by ionic gelation of chitosan with sodium tripolyphosphate (STPP)
and subsequent lyophilization. A Plackett Burman screening design, 32 full factorial design, and
overlay plots were sequentially employed to optimize the formulation. The mean particle size, %
entrapment efficiency, in vitro drug release, and minimum inhibitory concentration were all evaluated.

Results:
The Pareto chart from the Placket Burman screening design revealed that the concentrations
of chitosan and STPP was found to be significant (p < 0.05). Further analysis by 32 full factorial
design revealed that F-ratio for each model generated was found to be greater than the theoretical
value (p < 0.05), confirming the significance of each model.

Conclusion:
The optimized formulation showed a mean particle size of 171.5 nm, sustained the
drug release up to 24 h in simulated lung fluid, and revealed MMAD of 3.18 μm, which can confirm
delivery of the drug to the deep lung region. However, further in vivo studies are required to
design a suitable dosage regimen and establish the fate of nanoparticles for safe and efficacious delivery
of the drug.
Cardiovascular Changes in Menopause
Authors: Nair Anjana R. , Pillai Aiswarya J. , Nair Nandini 
Published: November 2020

:
Menopause is associated with changes consistent with cardiovascular aging. The effects
of cardiac disease are multifaceted, affecting endothelial function, coronary artery physiology and
metabolic dysfunction leading to structural changes in the coronary anatomy. A systematic review
of literature from 1986 to 2019 was conducted using PubMed and Google Scholar. The search was
directed to retrieve papers that addressed the changes in cardiovascular physiology in menopause
and the current therapies available to treat cardiovascular manifestations of menopause. The
metabolic and clinical factors secondary to menopause, such as dyslipidemia, insulin resistance, fat
redistribution and systemic hypertension, contribute to the accelerated risk for cardiovascular aging
and disease. Atherosclerosis appears to be the end result of the interaction between cardiovascular
risk factors and their accentuation during the perimenopausal period. Additionally, complex interactions
between oxidative stress and levels of L-arginine and ADMA may also influence endothelial
dysfunction in menopause. The increased cardiovascular risk in menopause stems from the exaggerated
effects of changing physiology on the cardiovascular system affecting peripheral, cardiac and
cerebrovascular beds. The differential effects of menopause on cardiovascular disease at the subclinical,
biochemical and molecular levels form the highlights of this review.
Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues
Authors: Ren Houwei , Dhanaraj Premnath , Enoch Israel V.M.V. , Paulraj Mosae Selvakumar , M. Indiraleka 
Published: November 2020

Objectives:
The aim of the present study is to carry out a simple synthesis of aminoantipyrine analogues and exploration of their antibacterial, cytotoxic, and anticonvulsant potential.

Methods:
The compounds were characterized employing multi-spectroscopic methods. The in vitro pharmacological response of a series of bacteria were screened employing serial dilution method. The derivatives were screened against maximal electro-shock for their anticonvulsant activity. Molecular docking was carried out to optimize the interaction of the
compounds with HPV16-E7 receptors. Further, the in vitro cytotoxicity was tested against human cervical cancer (SiHa) cell
lines.

Results:
The compounds show protection against maximal electroshock, esp. 3-nirto- and 4-
methyl-3-nitrobenzamido derivatives. In addition, they reveal appreciable DNA cleavage activities
and interactions with HPV16-E7 protein receptors, esp. 3,5-dinitro- and 4-methyl-3-nitrobenzamido
derivatives. Furthermore, they show potent activity against cervical cancer cells (LD50 value up to
1200 in the case of 4-methyl-3-nitrobenzamido derivative and an inhibition of a maximum of
~97% of cells).

Conclusions:
The simply synthesized aminoantipyrine derivatives show a variety of biological activities like antibacterial
and anticancer effects. In addition, this is the first study demonstrating that 4-aminoantipyrine derivatives shows an anticonvulsant activity.
Starch as a Sustainable Fuel for Solution Combustion Synthesis: Nanomaterials for Energy and Environmental Applications
Authors: dos Santos Garrido Francisco Manoel , Argolo Maria Isabel Spitz , Medeiros Marta Eloísa , Siqueira José Márcio 
Published: November 2020

Background:Currently, solution combustion synthesis (SCS) is considered a reproducible, flexible, and low-cost synthesis method for the preparation of nanomaterials. A new trend in the SCS method is the use of less polluting fuels, such as starch. The use of starch as fuel in SCS is very interesting for green chemistry, as it is renewable and has several advantages, including its abundance, low-cost, and non-toxicity.Objective:This paper provides a comprehensive review of the SCS method using starch as fuel. The main advantages of using starch as fuel will be illustrated with a wide variety of examples, highlighting its impact on the preparation of nanomaterials for energy and environmental applications.Conclusion:In a combustion reaction using starch as fuel, several positive effects are expected, such as non-violent propagation, combustion with the production of non-toxic gases (mainly CO2and H2O), and development of pores during the release of gases. For example, several macroporous metal oxide foams were prepared using the SCS method, through an appropriate combination of urea and starch fuels. With this approach, it is possible to control the structure, lattice defects, crystallite size, specific surface area, porosity, and other characteristics of the synthetized nanomaterial. For example, by combining starch with other fuels, it is possible to control the concentration of lattice defects in metal oxides and modify the optical properties of these materials. These properties are of fundamental importance for the performance of these materials and their subsequent application in electrodes, electrocatalysts, and photocatalysts in the areas of energy and environment.
Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell
Authors: Tsanov Vasil , Tsanov Hristo 
Published: November 2020

Background:
This article concentrates on the processes occurring in the medium around the cancer
cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of
natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and
associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semiempirical
methods, are considered.

Objective:
Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have
adapted to take food containing nitrile glycosides and/or modified forms to counteract "external" bioactive
activity. For their part, cancers have evolved to create conditions around their cells that eliminate their active
apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract
it. In this way, it protects itself and the gene sets and develops accordingly.

Methods:
Pedestal is derived that closely defines the processes of hydrolysis in the blood, the transfer of a
specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent densityfunctional
quantum-chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to
bioactive forms causing chemical apoptosis of the cell-independent of its non-genetic set, which seeks to
counteract the process.

Results:
Used in oncology, it could turn a cancer from a lethal to a chronic disease (such as diabetes). The
causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer
cells could be kept low for a long time (even a lifetime).

Conclusion:
The amide derivatives of nitrile glycosides exhibit anticancer activity; the cancer cell probably
seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and
the amide-carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer
cell itself and thus block and/or permanently damage its normal physiology.
Recent Patents on Blueberry Picking
Authors: Bao Yudong , Li Kai , Zhao Yanling , Guo Yanling , Qi Dongbo 
Published: November 2020

Background:
With a growing demand for blueberries, the planting area of blueberries is also
increasing. However, the main method of picking blueberries is the traditional manual picking, so
the operation of picking is the most time-consuming and laborious in the chain of production.

Objective:
By analyzing and discussing the patents of equipment of blueberry picking, some valuable conclusions have been drawn to predict the future research and development of equipment of blueberry picking.

Methods:
This paper sketches out various current representative patents relevant to equipment of blueberry picking.

Results:
Through summarizing a large number of patents about equipment of blueberry picking, the
characters of those patents are analyzed and compared, and further development tendency of equipment
of blueberry picking is discussed.

Conclusion:
The research on the multifunction, intelligence, versatility of blueberry picking machine
is helpful in solving the problems of low efficiency, low quality and poor versatility.