bluuebunny/crossref_metadata_2025_split huggingface dataset:
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer
Authors: Toledo Alejandro Gómez , Pihl Jessica , Spliid Charlotte B , Persson Andrea , Nilsson Jonas , Pereira Marina Ayres , Gustavsson Tobias , Choudhary Swati , Zarni Oo Htoo , Black Peter C , Daugaard Mads , Esko Jeffrey D , Larson Göran , Salanti Ali , Clausen Thomas Mandel 
Published: April 2020

AbstractChondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein, expressed at the surface of infected erythrocytes during Plasmodium falciparum infection. Infected cells adhere to syncytiotrophoblasts or get trapped within the intervillous space by binding to a determinant in a 4-O-sulfated CS chains. However, the exact structure of these glycan sequences remains unclear. VAR2CSA-reactive CS is also expressed by tumor cells, making it an attractive target for cancer diagnosis and therapeutics. The identities of the proteoglycans carrying these modifications in placental and cancer tissues remain poorly characterized. This information is clinically relevant since presentation of the glycan chains may be mediated by novel core proteins or by a limited subset of established proteoglycans. To address this question, VAR2CSA-binding proteoglycans were affinity-purified from the human placenta, tumor tissues and cancer cells and analyzed through a specialized glycoproteomics workflow. We show that VAR2CSA-reactive CS chains associate with a heterogenous group of proteoglycans, including novel core proteins. Additionally, this work demonstrates how affinity purification in combination with glycoproteomics analysis can facilitate the characterization of CSPGs with distinct CS epitopes. A similar workflow can be applied to investigate the interaction of CSPGs with other CS binding lectins as well.
Hearing in 3D: Directional Auditory Sensitivity of Northern Saw-Whet Owls (Aegolius acadicus)
Authors: de Koning Megan , Beatini Julia R , Proudfoot Glenn A , Gall Megan D 
Published: April 2020

AbstractNorthern saw-whet owls (Aegolius acadicus) are nocturnal predators that are able to acoustically localize prey with great accuracy; an ability that is attributed to their unique asymmetrical ear structure. While a great deal of research has focused on open loop sound localization prior to flight in owls (primarily barn owls), directional sensitivity of the ears may also be important in locating moving prey on the wing. Furthermore, directionally sensitive ears may also reduce the effects of masking noise, either from the owls’ wings during flight or environmental noise (e.g., wind and leaf rustling), by enhancing spatial segregation of target sounds and noise sources. Here, we investigated auditory processing of Northern saw-whet owls in three-dimensional space using auditory evoked potentials (AEPs). We simultaneously evoked auditory responses in two channels (right and left ear) with broadband clicks from a sound source that could be manipulated in space. Responses were evoked from 66 spatial locations, separated by 30° increments in both azimuth and elevation. We found that Northern saw-whet owls had increased sensitivity to sound sources directly in front of and above their beaks and decreased sensitivity to sound sources below and behind their heads. The spatial region of highest sensitivity extends from the lower beak to the crown of the head and 30° left or right of the median plane, dropping off beyond those margins. Directional sensitivity is undoubtedly useful during foraging and predator evasion, and may also reduce the effect of masking noise from the wings during flight due to the spatial segregation of the noise and targets of interest.
A PDE model for bleb formation and interaction with linker proteins
Authors: Werner Philipp , Burger Martin , Pietschmann Jan-Frederik 
Published: April 2020

AbstractThe aim of this paper is to further develop mathematical models for bleb formation in cells, including cell membrane interactions with linker proteins. This leads to nonlinear reaction–diffusion equations on a surface coupled to fluid dynamics in the bulk. We provide a detailed mathematical analysis and investigate some singular limits of the model, connecting it to previous literature. Moreover, we provide numerical simulations in different scenarios, confirming that the model can reproduce experimental results on bleb initiation.
On the Finiteness of Quantum K-Theory of a Homogeneous Space
Authors: Anderson David , Chen Linda , Tseng Hsian-Hua 
Published: April 2020

Abstract
We show that the product in the quantum K-ring of a generalized flag manifold $G/P$ involves only finitely many powers of the Novikov variables. In contrast to previous approaches to this finiteness question, we exploit the finite difference module structure of quantum K-theory. At the core of the proof is a bound on the asymptotic growth of the $J$-function, which in turn comes from an analysis of the singularities of the zastava spaces studied in geometric representation theory. An appendix by H. Iritani establishes the equivalence between finiteness and a quadratic growth condition on certain shift operators.
Rapid Deployment of Inpatient Telemedicine In Response to COVID-19 Across Three Health Systems
Authors: Vilendrer Stacie , Patel Birju , Chadwick Whitney , Hwa Michael , Asch Steven , Pageler Natalie , Ramdeo Rajiv , Saliba-Gustafsson Erika A , Strong Philip , Sharp Christopher 
Published: April 2020

Abstract

Objective
To reduce pathogen exposure, conserve personal protective equipment, and facilitate health care personnel work participation in the setting of the COVID-19 pandemic, three affiliated institutions rapidly and independently deployed inpatient telemedicine programs during March 2020. We describe key features and early learnings of these programs in the hospital setting.

Methods
Relevant clinical and operational leadership from an academic medical center, pediatric teaching hospital, and safety net county health system met to share learnings shortly after deploying inpatient telemedicine. A summative analysis of their learnings was re-circulated for approval.

Results
All three institutions faced pressure to urgently standup new telemedicine systems while still maintaining secure information exchange. Differences across patient demographics and technological capabilities led to variation in solution design, though key technical considerations were similar. Rapid deployment in each system relied on readily available consumer-grade technology, given the existing familiarity to patients and clinicians and minimal infrastructure investment. Preliminary data from the academic medical center over one month suggested positive adoption with 631 inpatient video calls lasting an average (standard deviation) of 16.5 minutes (19.6) based on inclusion criteria.

Discussion
The threat of an imminent surge of COVID-19 patients drove three institutions to rapidly develop inpatient telemedicine solutions. Concurrently, federal and state regulators temporarily relaxed restrictions that would have previously limited these efforts. Strategic direction from executive leadership, leveraging off-the-shelf hardware, vendor engagement, and clinical workflow integration facilitated rapid deployment.

Conclusion
The rapid deployment of inpatient telemedicine is feasible across diverse settings as a response to the COVID-19 pandemic.
Multiplicity and Modifiers
Authors: Romoli Jacopo , Renans Agata 
Published: April 2020

AbstractA sentence with an adverbial modifier under negation like Mike didn’t wash the window with soap gives rise to an inference that Mike did wash the window. A sentence with a plural noun like Mike washed windows gives rise to a so-called ‘multiplicity’ inference that Mike washed multiple windows. In this note, we focus on the interaction between these two inferences in sentences containing both an adverbial modifier and a plural noun under negation, like Mike didn’t wash windows with soap. We observe that this sentence has a reading conveying that Mike didn’t wash any window with soap but that he did wash multiple windows (albeit not with soap). As we discuss, this reading is not predicted by any version of the implicature approach to the multiplicity inference, in combination with the implicature treatment of the inference of adverbial modifiers. We sketch two solutions for this problem. The first keeps the implicature approach to adverbial modifiers but adopts a non-implicature approach to multiplicity based on homogeneity. The second solution holds on to the implicature approach to the multiplicity inference but accounts for the inference of adverbial modifiers as a presupposition. In addition, it adopts the idea that presuppositions can be strengthened via implicatures, as proposed recently in the literature. Either way, the interaction between multiplicity and the inference of adverbial modifiers suggests that we cannot treat both as implicatures: if we want to treat either one as an implicature, we need to do something different for the other. We end by comparing the case above to analogous cases involving different scalar inferences and showing that the ambiguity approach to the multiplicity inference does not provide a solution to our problem.
Inner-Space and Liquid Myths: J.G. Ballard as a Post-Secular Writer
Authors: Bowyer Andrew D 
Published: April 2020

Abstract
British novelist James Graham Ballard (1930–2009) was an inveterate mythmaker. In this article, I characterise him as a post-secular writer who saw the imagination as a means to confront trauma, probe memory, and salvage meaning in a secular age. Anchoring the argument in a selection of novels and works that constitute his ‘autobiographical turn’, I suggest that resonances with contemporary theology may be detected, particularly the disruptive, anti-fascist, postmodern, ‘tehomic’ theology of Catherine Keller.
A precise benchmark for cluster scaling relations: Fundamental Plane, Mass Plane, and IMF in the Coma cluster from dynamical models
Authors: Shetty Shravan , Cappellari Michele , McDermid Richard M , Krajnović Davor , de Zeeuw P T , Davies Roger L , Kobayashi Chiaki 
Published: April 2020

ABSTRACT
We study a sample of 148 early-type galaxies in the Coma cluster using SDSS photometry and spectra, and calibrate our results using detailed dynamical models for a subset of these galaxies, to create a precise benchmark for dynamical scaling relations in high-density environments. For these galaxies, we successfully measured global galaxy properties, modelled stellar populations, and created dynamical models, and support the results using detailed dynamical models of 16 galaxies, including the two most massive cluster galaxies, using data taken with the SAURON IFU. By design, the study provides minimal scatter in derived scaling relations due to the small uncertainty in the relative distances of galaxies compared to the cluster distance. Our results demonstrate low (≤55 per cent for 90th percentile) dark matter fractions in the inner 1Re of galaxies. Owing to the study design, we produce the tightest, to our knowledge, IMF–σe relation of galaxies, with a slope consistent with that seen in local galaxies. Leveraging our dynamical models, we transform the classical Fundamental Plane of the galaxies to the Mass Plane. We find that the coefficients of the Mass Plane are close to predictions from the virial theorem, and have significantly lower scatter compared to the Fundamental Plane. We show that Coma galaxies occupy similar locations in the (M*–Re) and (M*−σe) relations as local field galaxies but are older. This, and the fact we find only three slow rotators in the cluster, is consistent with the scenario of hierarchical galaxy formation and expectations of the kinematic morphology–density relation.
The onset of instability in resonant chains
Authors: Pichierri Gabriele , Morbidelli Alessandro 
Published: April 2020

ABSTRACT
There is evidence that most chains of mean motion resonances of type k:k − 1 among exoplanets become unstable once the dissipative action from the gas is removed from the system, particularly for large N (the number of planets) and k (indicating how compact the chain is). We present a novel dynamical mechanism that can explain the origin of these instabilities and thus the dearth of resonant systems in the exoplanet sample. It relies on the emergence of secondary resonances between a fraction of the synodic frequency 2π(1/P1 − 1/P2) and the libration frequencies in the mean motion resonance. These secondary resonances excite the amplitudes of libration of the mean motion resonances, thus leading to an instability. We detail the emergence of these secondary resonances by carrying out an explicit perturbative scheme to second order in the planetary masses and isolating the harmonic terms that are associated with them. Focusing on the case of three planets in the 3:2–3:2 mean motion resonance as an example, a simple but general analytical model of one of these resonances is obtained, which describes the initial phase of the activation of one such secondary resonance. The dynamics of the excited system is also briefly described. Finally, a generalization of this dynamical mechanism is obtained for arbitrary N and k. This leads to an explanation of previous numerical experiments on the stability of resonant chains, showing why the critical planetary mass allowed for stability decreases with increasing N and k.
The impact of peculiar velocities on the estimation of the Hubble constant from gravitational wave standard sirens
Authors: Nicolaou Constantina , Lahav Ofer , Lemos Pablo , Hartley William , Braden Jonathan 
Published: April 2020

ABSTRACT
In this work, we investigate the systematic uncertainties that arise from the calculation of the peculiar velocity when estimating the Hubble constant (H0) from gravitational wave standard sirens. We study the GW170817 event and the estimation of the peculiar velocity of its host galaxy, NGC 4993, when using Gaussian smoothing over nearby galaxies. NGC 4993 being a relatively nearby galaxy, at ∼40 Mpc away, is subject to a significant effect of peculiar velocities. We demonstrate a direct dependence of the estimated peculiar velocity value on the choice of smoothing scale. We show that when not accounting for this systematic, a bias of ${\sim }200~{\rm km\, s^{-1}}$ in the peculiar velocity incurs a bias of ${\sim }4~{\rm km\, s^{-1}\, Mpc^{-1}}$ on the Hubble constant. We formulate a Bayesian model that accounts for the dependence of the peculiar velocity on the smoothing scale and by marginalizing over this parameter we remove the need for a choice of smoothing scale. The proposed model yields $H_0 = 68.6 ^{+14.0} _{-8.5}~{\rm km\, s^{-1}\, Mpc^{-1}}$. We demonstrate that under this model a more robust unbiased estimate of the Hubble constant from nearby GW sources is obtained.
Revealing the tidal scars of the Small Magellanic Cloud
Authors: De Leo Michele , Carrera Ricardo , Noël Noelia E D , Read Justin I , Erkal Denis , Gallart Carme 
Published: April 2020

ABSTRACT
Due to their close proximity, the Large and Small Magellanic Clouds (LMC/SMC) provide natural laboratories for understanding how galaxies form and evolve. With the goal of determining the structure and dynamical state of the SMC, we present new spectroscopic data for ∼3000 SMC red giant branch stars observed using the AAOmega spectrograph at the Anglo-Australian Telescope. We complement our data with further spectroscopic measurements from previous studies that used the same instrumental configuration as well as proper motions from the Gaia Data Release 2 catalogue. Analysing the photometric and stellar kinematic data, we find that the SMC centre of mass presents a conspicuous offset from the velocity centre of its associated H i gas, suggesting that the SMC gas is likely to be far from dynamical equilibrium. Furthermore, we find evidence that the SMC is currently undergoing tidal disruption by the LMC within 2 kpc of the centre of the SMC, and possibly all the way into the very core. This is revealed by a net outward motion of stars from the SMC centre along the direction towards the LMC and an apparent tangential anisotropy at all radii. The latter is expected if the SMC is undergoing significant tidal stripping, as we demonstrate using a suite of N-body simulations of the SMC/LMC system disrupting around the Milky Way. Our results suggest that dynamical models for the SMC that assume a steady state will need to be revisited.
The unusual broad-band X-ray spectral variability of NGC 1313 X-1 seen with XMM–Newton, Chandra, and NuSTAR
Authors: Walton D J , Pinto C , Nowak M , Bachetti M , Sathyaprakash R , Kara E , Roberts T P , Soria R , Brightman M , Canizares C R , Earnshaw H P , Fürst F , Heida M , Middleton M J , Stern D , Tao L , Webb N , Alston W N , Barret D , Fabian A C , Harrison F A , Kosec P 
Published: April 2020

ABSTRACT
We present results from the major coordinated X-ray observing programme on the ULX NGC 1313 X-1 performed in 2017, combining XMM–Newton, Chandra, and NuSTAR, focusing on the evolution of the broad-band (∼0.3–30.0 keV) continuum emission. Clear and unusual spectral variability is observed, but this is markedly suppressed above ∼10–15 keV, qualitatively similar to the ULX Holmberg IX X-1. We model the multi-epoch data with two-component accretion disc models designed to approximate super-Eddington accretion, allowing for both a black hole and a neutron star accretor. With regards to the hotter disc component, the data trace out two distinct tracks in the luminosity–temperature plane, with larger emitting radii and lower temperatures seen at higher observed fluxes. Despite this apparent anticorrelation, each of these tracks individually shows a positive luminosity–temperature relation. Both are broadly consistent with L ∝ T4, as expected for blackbody emission with a constant area, and also with L ∝ T2, as may be expected for an advection-dominated disc around a black hole. We consider a variety of possibilities for this unusual behaviour. Scenarios in which the innermost flow is suddenly blocked from view by outer regions of the super-Eddington disc/wind can explain the luminosity–temperature behaviour, but are difficult to reconcile with the lack of strong variability at higher energies, assuming this emission arises from the most compact regions. Instead, we may be seeing evidence for further radial stratification of the accretion flow than is included in the simple models considered, with a combination of winds and advection resulting in the suppressed high-energy variability.
Optical spectral characterization of the TeV extreme blazar 2WHSP J073326.7+515354
Authors: Becerra González J , Acosta-Pulido J A , Clavero R 
Published: April 2020

ABSTRACT
The emission from the relativistic jets in blazars usually outshines their host galaxies, challenging the determination of their distances and the characterization of the stellar population. The situation becomes more favourable in the case of the extreme blazars (EHBLs), for which the bulk of the emission of the relativistic jets is emitted at higher energies, unveiling the optical emission from the host galaxy. The distance determination is fundamental for the study of the intrinsic characteristics of the blazars, especially to estimate the intrinsic gamma-ray spectra distorted due to the interaction with the extragalactic background light. In this work, we report on the properties of 2WHSP J073326.7+515354 host galaxy in the optical band, which is one of the few EHBLs detected at TeV energies. We present the first measurement of the distance of the source, z = 0.065 04 ± 0.000 02 (velocity dispersion $\sigma =237 \pm 9\, \mathrm{km s^{-1}}$). We also perform a detailed study of the stellar population of its host galaxy. We find that the mass-weighted mean stellar age is $11.72\pm 0.06\, \mathrm{Gyr}$ and the mean metallicity [M/H] = 0.159 ± 0.016. In addition, a morphological study of the host galaxy is also carried out. The surface brightness distribution is modelled by a composition of a dominant classical bulge (Re = 3.77 ± 1 arcsec or equivalently 4.74 kpc) plus an unresolved source which corresponds to the active nucleus. The black hole mass is estimated using both the mass relation with the velocity dispersion and the absolute magnitude from the bulge yielding comparable results: $(4.8\pm 0.9)\times 10^8$ and $(3.7\pm 1.0)\times 10^8\, \mathrm{ M}_{\odot }$, respectively.
Shot noise in multitracer constraints on fNL and relativistic projections: Power spectrum
Authors: Ginzburg Dimitry , Desjacques Vincent 
Published: April 2020

ABSTRACT
Multiple tracers of the same surveyed volume can enhance the signal-to-noise on a measurement of local primordial non-Gaussianity and the relativistic projections. Increasing the number of tracers comparably increases the number of shot noise terms required to describe the stochasticity of the data. Although the shot noise is white on large scales, it is desirable to investigate the extent to which it can degrade constraints on the parameters of interest. In a multitracer analysis of the power spectrum, a marginalization over shot noise does not degrade the constraints on fNL by more than ∼30 per cent so long as haloes of mass $M\lesssim 10^{12}\, \mathrm{M}_\odot$ are resolved. However, ignoring cross shot noise terms induces large systematics on a measurement of fNL at redshift z &lt; 1 when small mass haloes are resolved. These effects are less severe for the relativistic projections, especially for the dipole term. In the case of a low and high mass tracer, the optimal sample division maximizes the signal-to-noise on fNL and the projection effects simultaneously, reducing the errors to the level of ∼10 consecutive mass bins of equal number density. We also emphasize that the non-Poissonian noise corrections that arise from small-scale clustering effects cannot be measured with random dilutions of the data. Therefore, they must either be properly modelled or marginalized over.
Magnetohydrodynamic modelling of star–planet interaction and associated auroral radio emission
Authors: Turnpenney Sam , Nichols J D , Wynn G A , Jia X 
Published: April 2020

ABSTRACT
We present calculations of auroral radio powers of magnetized hot Jupiters orbiting Sun-like stars, computed using global magnetohydrodynamic (MHD) modelling of the magnetospheric and ionospheric convection arising from the interaction between the magnetosphere and the stellar wind. Exoplanetary auroral radio powers are traditionally estimated using empirical or analytically derived relations, such as the radiometric Bode’s law (RBL), which relates radio power to the magnetic or kinetic energy dissipated in the stellar wind–planet interaction. Such methods risk an oversimplification of the magnetospheric electrodynamics giving rise to radio emission. As the next step towards a self-consistent picture, we model the stellar wind–magnetosphere–ionosphere coupling currents using a 3D MHD model. We compute electron-cyclotron maser instability-driven emission from the calculated ionospheric field-aligned current density. We show that the auroral radio power is highly sensitive to interplanetary magnetic field (IMF) strength, and that the emission is saturated for plausible hot Jupiter Pedersen conductances, indicating that radio power may be largely independent of ionospheric conductance. We estimate peak radio powers of 1014 W from a planet exposed to an IMF strength of 103 nT, implying flux densities at a distance of 15 pc from Earth potentially detectable with current and future radio telescopes. We also find a relation between radio power and planetary orbital distance that is broadly consistent with results from previous analytic models of magnetosphere–ionosphere coupling at hot Jupiters, and indicates that the RBL likely overestimates the radio powers by up to two orders of magnitude in the hot Jupiter regime.