bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ward identity for loop level soft photon theorem for massless QED coupled to gravity
Authors: Bhatkar Sayali Atul 
Published: October 2020

Abstract
Motivated by Campiglia and Laddha [1], we show that the Sahoo-Sen soft photon theorem [2] for loop amplitudes is equivalent to an asymptotic conservation law. This asymptotic charge is directly related to the dressing of fields due to long range forces exclusively present in four spacetime dimensions. In presence of gravity, the new feature is that photons also acquire a dressing due to long range gravitational force and this dressing contributes to the asymptotic charge.
Hybrid volumetric modulated arc therapy for hypofractionated radiotherapy of breast cancer: a treatment planning study
Authors: Venjakob Alexander , Oertel Michael , Hering Dominik Alexander , Moustakis Christos , Haverkamp Uwe , Eich Hans Theodor 
Published: October 2020

Abstract
Purpose
This study aims to evaluate the best possible practice using hybrid volumetric modulated arc therapy (H-VMAT) for hypofractionated radiation therapy of breast cancer. Different combinations of H‑VMAT—a combination of three-dimensional radiotherapy (3D-CRT) and VMAT—were analyzed regarding planning target volume (PTV), dose coverage, and exposure to organs at risk (OAR).

Methods
Planning computed tomography scans were acquired in deep-inspiration breath-hold. A total of 520 treatment plans were calculated and evaluated for 40 patients, comprising six different H‑VMAT plans and a 3D-CRT plan as reference. H‑VMAT plans consisted of two treatment plans including 3D-CRT and VMAT. During H‑VMAT planning, the use of hard wedge filters (HWF) and beam energies were varied. The reference plans were planned with mixed beam energies and the inclusion/omission of HWF.

Results
Compared to the reference treatment plans, all H‑VMAT plans showed consistently better PTV dose coverage, conformity, and homogeneity. Additionally, OAR protection was significantly improved with several H‑VMAT combinations (p < 0.05). The comparison of different H‑VMAT combinations showed that inclusion of HWF in the base plan had a negative impact on PTV dose coverage, conformity, and OAR exposure. It also increased the planned monitor units and beam-on time. Advantages of using lower beam energies (6-MV photons) in both the base plan and in the VMAT supplementary dose were observed.

Conclusion
The H‑VMAT technique is an effective possibility for generating homogenous and conformal dose distributions. With the right choice of H‑VMAT combination, superior OAR protection is achieved compared to 3D-CRT.
Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice
Authors: Nguyen-Tu Marie-Sophie , Martinez-Sanchez Aida , Leclerc Isabelle , Rutter Guy A. , da Silva Xavier Gabriela 
Published: October 2020

Abstract
Aims/hypothesis
Transcription factor 7-like 2 (TCF7L2) is a downstream effector of the Wnt/β-catenin signalling pathway implicated in type 2 diabetes risk through genome-wide association studies. Although its expression is critical for adipocyte development, the potential roles of changes in adipose tissue TCF7L2 levels in diabetes risk are poorly defined. Here, we investigated whether forced changes in Tcf7l2 expression in adipocytes affect whole body glucose or lipid metabolism and crosstalk between disease-relevant tissues.

Methods
Tcf7l2 was selectively ablated in mature adipocytes in C57BL/6J mice using Cre recombinase under Adipoq promoter control to recombine Tcf7l2 alleles floxed at exon 1 (referred to as aTCF7L2 mice). aTCF7L2 mice were fed normal chow or a high-fat diet for 12 weeks. Glucose and insulin sensitivity, as well as beta cell function, were assessed in vivo and in vitro. Levels of circulating NEFA, selected hormones and adipokines were measured using standard assays.

Results
Reduced TCF7L2 expression in adipocytes altered glucose tolerance and insulin secretion in male but not in female mice. Thus, on a normal chow diet, male heterozygote knockout mice (aTCF7L2het) exhibited impaired glucose tolerance at 16 weeks (p = 0.03) and increased fat mass (1.4 ± 0.1-fold, p = 0.007) but no changes in insulin secretion. In contrast, male homozygote knockout (aTCF7L2hom) mice displayed normal body weight but impaired oral glucose tolerance at 16 weeks (p = 0.0001). These changes were mechanistically associated with impaired in vitro glucose-stimulated insulin secretion (decreased 0.5 ± 0.1-fold vs control mice, p = 0.02) and decreased levels of the incretins glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (0.6 ± 0.1-fold and 0.4 ± 0.1-fold vs control mice, p = 0.04 and p < 0.0001, respectively). Circulating levels of plasma NEFA and fatty acid binding protein 4 were increased by 1.3 ± 0.1-fold and 1.8 ± 0.3-fold vs control mice (p = 0.03 and p = 0.05, respectively). Following exposure to a high-fat diet for 12 weeks, male aTCF7L2hom mice exhibited reduced in vivo glucose-stimulated insulin secretion (0.5 ± 0.1-fold vs control mice, p = 0.02).

Conclusions/interpretation
Loss of Tcf7l2 gene expression selectively in adipocytes leads to a sexually dimorphic phenotype, with impairments not only in adipocytes, but also in pancreatic islet and enteroendocrine cells in male mice only. Our findings suggest novel roles for adipokines and incretins in the effects of diabetes-associated variants in TCF7L2, and further illuminate the roles of TCF7L2 in glucose homeostasis and diabetes risk.
Abusive head trauma: experience improves diagnosis
Authors: Porto Luciana , Bartels Marco Baz , Zwaschka Jonas , You Se-Jong , Polkowski Christoph , Luetkens Julian , Endler Christoph , Kieslich Matthias , Hattingen Elke 
Published: October 2020

AbstractPurposeThe diagnosis of abusive head trauma (AHT) is complex and neuroimaging plays a crucial role. Our goal was to determine whether non-neuroradiologists with standard neuroradiology knowledge perform as well as neuroradiologists with experience in pediatric neuroimaging in interpreting MRI in cases of presumptive AHT (pAHT).MethodsTwenty children were retrospectively evaluated. Patients had been diagnosed with pAHT (6 patients), non-abusive head trauma-NAHT (5 patients), metabolic diseases (3 patients), and benign enlargement of the subarachnoid spaces (BESS) (6 patients). The MRI was assessedblindly, i.e., no clinical history was given to the 3 non-neuroradiologists and 3 neuroradiologists from 2 different institutions.ResultsBlindly, neuroradiologists demonstrated higher levels of sensitivity and positive predictive value in the diagnosis of pAHT (89%) than non-neuroradiologists (50%). Neuroradiologists chose correctly pAHT as the most probable diagnosis 16 out of 18 times; in contrast, non-neuroradiologists only chose 9 out of 18 times. In our series, the foremost important misdiagnosis for pAHT was NAHT (neuroradiologists twice and non-neuroradiologists 5 times). Only victims of motor vehicle accidents were blindly misdiagnosed as pAHT. No usual household NAHT was not misdiagnosed as pAHT. Neuroradiologists correctly ruled out pAHT in all cases of metabolic diseases and BESS.ConclusionMRI in cases of suspected AHT should be evaluated by neuroradiologists with experience in pediatric neuroimaging. Neuroradiologists looked beyond the subdural hemorrhage (SDH) and were more precise in the assessment of pAHT and its differential diagnosis than non-neuroradiologists were. It seems that non-neuroradiologists mainly assess whether or not a pAHT is present depending on the presence or absence of SDH.
Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia – a nested case-control study
Authors: Cornelissen Loes L. , Kreuger Aukje L. , Caram-Deelder Camila , Middelburg Rutger A. , Kerkhoffs Jean Louis H. , von dem Borne Peter A. , Beckers Erik A. M. , de Vooght Karen M. K. , Kuball Jürgen , Zwaginga J. J. , van der Bom Johanna G. 
Published: October 2020

AbstractWe designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859 leukemia patients, cases (n = 17) were patients diagnosed with intracranial hemorrhage who were matched with control patients (n = 55). We documented platelet counts and transfusions for seven days before the intracranial hemorrhage in cases and in a “matched” week for control patients. Three measures of platelet count exposure were assessed in four potentially important time periods before hemorrhage. Among these leukemia patients, we observed the cumulative incidence of intracranial hemorrhage of 3.5%. Low platelet counts were, especially in the three to seven days preceding intracranial hemorrhage, associated with the incidence of intracranial hemorrhage, although with wide confidence intervals. Platelet transfusions during the week preceding the hemorrhage were associated with higher incidences of intracranial hemorrhage; rate ratios (95% confidence interval) for one or two platelet transfusions and for more than two transfusions compared with none were 4.04 (0.73 to 22.27) and 8.91 (1.53 to 51.73) respectively. Thus, among acute leukemia patients, the risk of intracranial hemorrhage was higher among patients with low platelet counts and after receiving more platelet transfusions. Especially, the latter is likely due to clinical factors leading to increased transfusion needs.
A low order dynamical model for runoff predictability
Authors: Olson Roman , Timmermann Axel , Lee June-Yi , An Soon-Il 
Published: October 2020

AbstractRecent work has identified potential multi-year predictability in soil moisture (Chikamoto et al. in Clim Dyn 45(7–8):2213–2235, 2015). Whether this long-term predictability translates into an extended predictability of runoff still remains an open question. To address this question we develop a physically-based zero-dimensional stochastical dynamical model. The model extends previous work of Dolgonosov and Korchagin (Water Resour 34(6):624–634, 2007) by including a runoff-generating soil moisture threshold. We consider several assumptions on the input rainfall noise. We analyze the applicability of analytical solutions for the stationary probability density functions (pdfs) and for waiting times for runoff under different assumptions. Our results suggest that knowing soil moisture provides important information on the waiting time for runoff. In addition, we fit the simple model to daily NCEP1 reanalysis output on a near-global scale, and analyze fitted model performance. Over many tropical regions, the model reproduces the simulated runoff in NCEP1 reasonably well. More detailed analysis over a single gridpoint illustrates that the model, despite its simplicity, is able to capture some key features of the runoff time series and pdfs of a more complex model. Our model exhibits runoff predictability of up to two months in advance. Our results suggest that there is an optimal predictability “window” in the transition zone between runoff-generating and dry conditions. Our model can serve as a “null hypothesis” model reference against more complex models for runoff predictability.
A single tree model to consistently simulate cooling, shading, and pollution uptake of urban trees
Authors: Pace Rocco , De Fino Francesco , Rahman Mohammad A. , Pauleit Stephan , Nowak David J. , Grote Rüdiger 
Published: October 2020

AbstractExtremely high temperatures, which negatively affect the human health and plant performances, are becoming more frequent in cities. Urban green infrastructure, particularly trees, can mitigate this issue through cooling due to transpiration, and shading. Temperature regulation by trees depends on feedbacks among the climate, water supply, and plant physiology. However, in contrast to forest or general ecosystem models, most current urban tree models still lack basic processes, such as the consideration of soil water limitation, or have not been evaluated sufficiently. In this study, we present a new model that couples the soil water balance with energy calculations to assess the physiological responses and microclimate effects of a common urban street-tree species (Tilia cordataMill.) on temperature regulation. We contrast two urban sites in Munich, Germany, with different degree of surface sealing at which microclimate and transpiration had been measured. Simulations indicate that differences in wind speed and soil water supply can be made responsible for the differences in transpiration. Nevertheless, the calculation of the overall energy balance showed that the shading effect, which depends on the leaf area index and canopy cover, contributes the most to the temperature reduction at midday. Finally, we demonstrate that the consideration of soil water availability for stomatal conductance has realistic impacts on the calculation of gaseous pollutant uptake (e.g., ozone). In conclusion, the presented model has demonstrated its ability to quantify two major ecosystem services (temperature mitigation and air pollution removal) consistently in dependence on meteorological and site conditions.
Regular generalized solutions to semilinear wave equations
Authors: Deguchi Hideo , Oberguggenberger Michael 
Published: October 2020

AbstractThe paper is devoted to proving an existence and uniqueness result for generalized solutions to semilinear wave equations with a small nonlinearity in space dimensions 1, 2, 3. The setting is the one of Colombeau algebras of generalized functions. It is shown that for a nonlinearity of arbitrary growth and sign, but multiplied with a small parameter, the initial value problem for the semilinear wave equation has a unique solution in the Colombeau algebra of generalized functions of bounded type. The proof relies on a fixed point theorem in the ultra-metric topology on the algebras involved. In classical terms, the result says that the semilinear wave equations under consideration have global classical solutions up to a rapidly vanishing error.
Comparison of supportive regulatory measures for pediatric medical device development in Japan and the United States
Authors: Takahashi Sara , Iwasaki Kiyotaka , Shirato Haruki , Ho Mami , Umezu Mitsuo 
Published: October 2020

AbstractFurther development of medical devices for children is required in Japan, but the development of such devices is delayed compared to that of medical devices for adults. Herein, we investigated policies for advancing the development of pediatric medical devices in Japan and the United States. Considering the achievements of each policy, we proposed a strategy to promote further development of pediatric medical devices in Japan. We investigated policies for supporting the development of pediatric medical devices and approved cases in Japan and the United States by searching contents of websites of regulatory bodies and other related administrations, and scientific papers. We found the main six policies in Japan and nine main policies in the United States for the development of pediatric medical devices. In the United States, various measures have initiated mainly in the 2000s, while in Japan, the main measures have been in place since 2013. Similarities were found in both countries, such as subsidies for application fees and research and development expenses, exemption of requirements for regulatory approval, and priority review and consultation by the regulatory body. Our study revealed that there are similarities in initiatives by both countries. To promote further development of pediatric medical devices in the future, improvements to expediting the review process to approval by the regulatory body, global development, and implementation of alternative measures to ensure the efficacy and safety of the device instead of large-scale clinical trials should be anticipated through cooperation among industry, government, and academia.
The EUMETNET AutoPollen programme: establishing a prototype automatic pollen monitoring network in Europe
Authors: Clot Bernard , Gilge Stefan , Hajkova Lenka , Magyar Donát , Scheifinger Helfried , Sofiev Mikhail , Bütler Fabienne , Tummon Fiona 
Published: October 2020

AbstractOperational pollen monitoring networks have developed across Europe, and the world more generally, in response to the increasing prevalence of pollen allergy and asthma. Routine pollen observations are in large part currently still based on time-intensive manual techniques developed in the 1950s. These methods suffer from low temporal resolution and long delays in data availability. Recent technological developments are revolutionising the field making real-time high-temporal resolution measurements possible. This paper describes the rationale behind the EUMETNET AutoPollen programme, which aims to develop a prototype automatic pollen monitoring network across Europe. We provide a brief description of the current state-of-the-art, then an overview of new technologies, and finally the main tasks of the AutoPollen programme.
The Role of Adolescents’ and Their Parents’ Temperament Types in Adolescents’ Academic Emotions: A Goodness-of-Fit Approach
Authors: Lahdelma Pinja , Tolonen Maria , Kiuru Noona , Hirvonen Riikka 
Published: October 2020

Abstract
Background
Academic emotions (e.g., enjoyment of learning or anxiety) play a significant role in academic performance and educational choices. An important factor explaining academic emotions can be students’ temperament and the goodness-of-fit between their temperament and their social environment, including parents.

Objective
This study investigated the unique and interactive effects of early adolescents’ and their parents’ temperament types on adolescents’ academic emotions in literacy and mathematics.

Method
The participants in the study consisted of 690 adolescent–parent dyads. Parents rated their own and their adolescents’ temperaments, and adolescents reported their positive and negative emotions in literacy and mathematics.

Results
The results showed that adolescents’ temperament type was significantly related to their negative emotions in both school subjects. Adolescents with an undercontrolled temperament reported more anger compared to adolescents with a resilient or overcontrolled temperament, and more anxiety, shame, and hopelessness compared to resilient adolescents. In addition, undercontrolled adolescents reported more boredom in mathematics than resilient or overcontrolled adolescents. The parents’ temperament type was related to positive emotions. Adolescents of resilient parents reported greater pride in mathematics than adolescents of undercontrolled or overcontrolled parents and higher hope in mathematics than adolescents of overcontrolled parents. Finally, overcontrolled adolescents with a resilient or overcontrolled parent reported higher enjoyment of mathematics and literacy in comparison to overcontrolled adolescents with an undercontrolled parent.

Conclusions
The findings of the study provide new knowledge about the role of temperament in the school context by showing that differences in temperamental reactivity and regulation relate to adolescents’ academic emotions.
An alternative material for an effective treatment technique proposal in the light of bibliometric profile of global scientific research on antibiotic resistance and Escherichia coli
Authors: Şahin Semanur , Akpinar Isil , Sivri Nüket 
Published: October 2020

AbstractAntibiotic resistance is considered by the countries to be a global health issue and a huge threat to public health. The reduction of resistant microorganisms from water/wastewater is of importance in environmental sciences since they are resistant in the aquatic environment. In this study, a bibliometric analysis of literature from the field of environmental science in water ecosystems from 2015 to 2019 was carried out using the keywords “Antibiotic Resistance (AR)” and “Escherichia coli”. Furthermore, using the keywords of “Fresh Water,” “Sea Water,” and “Waste Water,” 155, 52, and 57 studies were discovered, respectively. It is found that 217 studies of the total 2115 studies investigated on AR are mostly performed in the “Waste Water” by considering human health. Given the studies, an up-to-date solution should be proposed since the release of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) from wastewater treatment plants needs to be mitigated. For this reason, it is obvious that working on micro and macro ecosystems will increase the probability of solutions in antibiotic resistance. A discussion of removal techniques for coliform bacteria, particularly antibiotic resistant Escherichia coli, was presented. One of the unique values of this study is to offer an innovative solution that removing them by metal-organic frameworks (MOFs) are emerging crystalline hybrid materials. MOFs are used for environmental, biological, and food antimicrobial substances efficiently. Therefore, we can give inspiration to the future studies of antimicrobial resistance removal via adsorption using MOFs as adsorbents.
Transparency as design publicity: explaining and justifying inscrutable algorithms
Authors: Loi Michele , Ferrario Andrea , Viganò Eleonora 
Published: October 2020

AbstractIn this paper we argue that transparency of machine learning algorithms, just as explanation, can be defined at different levels of abstraction. We criticize recent attempts to identify the explanation of black box algorithms with making their decisions (post-hoc) interpretable, focusing our discussion on counterfactual explanations. These approaches to explanation simplify the real nature of the black boxes and risk misleading the public about the normative features of a model. We propose a new form of algorithmic transparency, that consists in explaining algorithms as an intentional product, that serves a particular goal, or multiple goals (Daniel Dennet’s design stance) in a given domain of applicability, and that provides a measure of the extent to which such a goal is achieved, and evidence about the way that measure has been reached. We call such idea of algorithmic transparency “design publicity.” We argue that design publicity can be more easily linked with the justification of the use and of the design of the algorithm, and of each individual decision following from it. In comparison to post-hoc explanations of individual algorithmic decisions, design publicity meets a different demand (the demand for impersonal justification) of the explainee. Finally, we argue that when models that pursue justifiable goals (which may include fairness as avoidance of bias towards specific groups) to a justifiable degree are used consistently, the resulting decisions are all justified even if some of them are (unavoidably) based on incorrect predictions. For this argument, we rely on John Rawls’s idea of procedural justice applied to algorithms conceived as institutions.