bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Glucocorticoids and Incident Treatment of Diabetes Mellitus, Hypertension, and Venous Thromboembolism in Children
Authors: Horton Daniel B , Xie Fenglong , Chen Lang , Mannion Melissa L , Curtis Jeffrey R , Strom Brian L , Beukelman Timothy 
Published: September 2020

AbstractRates of incident treatment were quantified in this study for diabetes mellitus, hypertension, and venous thromboembolism (VTE) associated with oral glucocorticoid exposure in children aged 1–18 years. The retrospective cohort included more than 930,000 children diagnosed with autoimmune diseases (namely, inflammatory bowel disease, juvenile idiopathic arthritis, or psoriasis) or a nonimmune comparator condition (attention-deficit/hyperactivity disorder) identified using US Medicaid claims (2000–2010). Associations of glucocorticoid dose per age- and sex-imputed weight with incident treated diabetes, hypertension, and VTE were estimated using Cox regression models. Crude rates were lowest for VTE (unexposed: 0.5/million person-days (95% confidence interval (CI): 0.4, 0.6); currently exposed: 15.6/million person-days (95% CI: 11.8, 20.1)) and highest for hypertension (unexposed: 6.7/million person-days (95% CI: 6.5, 7.0); currently exposed: 74.4/million person-days (95% CI: 65.7, 83.9)). Absolute rates for all outcomes were higher in unexposed and exposed children with autoimmune diseases compared with those with attention-deficit/hyperactivity disorder. Strong dose-dependent relationships were found between current glucocorticoid exposure and all outcomes (adjusted hazard ratios for high-dose glucocorticoids: for diabetes mellitus, 5.93 (95% CI: 3.94, 8.91); for hypertension, 19.13 (95% CI: 15.43, 23.73); for VTE, 16.16 (95% CI: 8.94, 29.22)). These results suggest strong relative risks, but low absolute risks, of newly treated VTE, diabetes, and especially hypertension in children taking high-dose oral glucocorticoids.
Possible role for acetylcysteine as a treatment for acute liver failure secondary to antitubercular medication use
Authors: Fox Ashley N , Nation Brooke E , Autry Marcus Tad , Johnson Peter N 
Published: September 2020

Abstract

Purpose
Drug-induced liver injury (DILI) that progresses to acute liver failure (ALF) has a high mortality rate, and therapeutic options are limited. Acetylcysteine has a labeled indication for use as an antidote for acetaminophen toxicity and has also been used with limited success in treatment of non–acetaminophen-induced liver injury, with small clinical trials indicating an increase in transplant-free survival. Recommendations for management of non–acetaminophen-induced DILI include withdrawal of the offending agent and supportive care. Treatment guidelines generally discourage a rechallenge with an offending medication, except in cases where there are no other therapeutic options for management of a serious disease, such as active tuberculosis (TB).

Summary
This case report describes the reversal of ALF due to DILI in a patient receiving antitubercular agents for active TB. After withdrawal of initially prescribed antitubercular agents, the patient was switched to a less hepatotoxic anti-TB regimen and intravenous acetylcysteine pending results of antimicrobial susceptibility testing. After stabilization of the patient’s liver enzyme levels, intravenous acetylcysteine was discontinued and oral acetylcysteine was continued for 5 days without an increase in hepatic enzyme levels or clinical deterioration. After 5 days, oral acetylcysteine was discontinued due to patient-reported nausea and vomiting.

Conclusion
Given the limited number of therapeutic interventions shown to be beneficial in ALF and data suggesting a protective effect against DILI with initiation of acetylcysteine at the start of treatment with anti-TB medications, acetylcysteine can be considered for patients with anti-TB – associated DILI.
Organized crime in cyberspace: How traditional organized criminal groups exploit the online peer-to-peer lending market in China
Authors: Wang Peng , Su Mei , Wang Jingyi 
Published: September 2020

AbstractHow do traditional organized criminal groups run their offline businesses on the internet? Drawing on interview data, news reports and interactions with illegal moneylenders, this article examines how loan sharks use the online peer-to-peer lending market to lend money to Chinese students at exorbitant interest rates. Illegal lenders employ techniques of deception, the sharing of compromising information (e.g. social contacts and nude photos) and professional legal services to develop internet-based loan scams to trap student borrowers. To enforce loan repayment, lenders have developed a new strategy: relational repression, which is the use of cyberviolence and the threat of revealing damaging information to clients’ social contacts. This puts enormous pressure on clients and their families to make payments. The use of relational repression reduces the need to resort to physical violence and bribe police officers.
Serotonergic Modulation of Spontaneous and Evoked Transmitter Release in Layer II Pyramidal Cells of Rat Somatosensory Cortex
Authors: Agahari Fransiscus Adrian , Stricker Christian 
Published: September 2020

AbstractAs axons from the raphe nuclei densely innervate the somatosensory cortex, we investigated how serotonin (5-HT) modulates transmitter release in layer II pyramidal cells of rat barrel cortex. In the presence of tetrodotoxin and gabazine, 10 μM 5-HT caused a waxing and waning in the frequency of miniature excitatory postsynaptic currents (mEPSC) with no effect on amplitude. Specifically, within 15 min of recording the mEPSC frequency initially increased by 28 ± 7%, then dropped to below control (−15 ± 3%), before resurging back to 27 ± 7% larger than control. These changes were seen in 47% of pyramidal cells (responders) and were mediated by 5-HT2C receptors (5-HT2CR). Waxing resulted from phospholipase C activation, IP3 production, and Ca2+ release from presynaptic stores. Waning was prevented if PKC was blocked. In contrast, in paired recordings, the unitary EPSC amplitude was reduced by 50 ± 3% after 5-HT exposure in almost all cases with no significant effect on paired-pulse ratio and synaptic dynamics. This sustained EPSC reduction was also caused by 5-HT2R, but was mediated by presynaptic Gβγ subunits likely limiting influx through CaV2 channels. EPSC reduction, together with enhanced spontaneous noise in a restricted subset of inputs, could temporarily diminish the signal-to-noise ratio and affect the computation in the neocortical microcircuit.
Right ventricular myocardial work: proof-of-concept for non-invasive assessment of right ventricular function
Authors: Butcher Steele C , Fortuni Federico , Montero-Cabezas Jose M , Abou Rachid , El Mahdiui Mohammed , van der Bijl Pieter , van der Velde Enno T , Ajmone Marsan Nina , Bax Jeroen J , Delgado Victoria 
Published: September 2020

Abstract

Aims
Right ventricular myocardial work (RVMW) is a novel method for non-invasive assessment of right ventricular (RV) function utilizing RV pressure–strain loops. This study aimed to explore the relationship between RVMW and invasive indices of right heart catheterization (RHC) in a cohort of patients with heart failure with reduced left ventricular ejection fraction (HFrEF), and to compare values of RVMW with those of a group of patients without cardiovascular disease.

Methods and results
Non-invasive analysis of RVMW was performed in 22 HFrEF patients [median age 63 (59–67) years] who underwent echocardiography and invasive RHC within 48 h. Conventional RV functional measurements, RV global constructive work (RVGCW), RV global work index (RVGWI), RV global wasted work (RVGWW), and RV global work efficiency (RVGWE) were analysed and compared with invasively measured stroke volume and stroke volume index. Non-invasive analysis of RVMW was also performed in 22 patients without cardiovascular disease to allow for comparison between groups. None of the conventional echocardiographic parameters of RV systolic function were significantly correlated with stroke volume or stroke volume index. In contrast, one of the novel indices derived non-invasively by pressure–strain loops, RVGCW, demonstrated a moderate correlation with invasively measured stroke volume and stroke volume index (r = 0.63, P = 0.002 and r = 0.59, P = 0.004, respectively). RVGWI, RVGCW, and RVGWE were significantly lower in patients with HFrEF compared to a healthy cohort, while values of RVGWW were significantly higher.

Conclusion
RVGCW is a novel parameter that provides an integrative analysis of RV systolic function and correlates more closely with invasively measured stroke volume and stroke volume index than other standard echocardiographic parameters.
How does embedded implementation research work? Examining core features through qualitative case studies in Latin America and the Caribbean
Authors: Varallyay N Ilona , Bennett Sara C , Kennedy Caitlin , Ghaffar Abdul , Peters David H 
Published: September 2020

Abstract
Innovative strategies are needed to improve the delivery of evidence-informed health interventions. Embedded implementation research (EIR) seeks to enhance the generation and use of evidence for programme improvement through four core features: (1) central involvement of programme/policy decision-makers in the research cycle; (2) collaborative research partnerships; (3) positioning research within programme processes and (4) research focused on implementation. This paper examines how these features influence evidence-to-action processes and explores how they are operationalized, their effects and supporting conditions needed. We used a qualitative, comparative case study approach, drawing on document analysis and semi-structured interviews across multiple informant groups, to examine three EIR projects in Bolivia, Colombia and the Dominican Republic. Our findings are presented according to the four core EIR features. The central involvement of decision-makers in EIR was enhanced by decision-maker authority over the programme studied, professional networks and critical reflection. Strong research–practice partnerships were facilitated by commitment, a clear and shared purpose and representation of diverse perspectives. Evidence around positioning research within programme processes was less conclusive; however, as all three cases made significant advances in research use and programme improvement, this feature of EIR may be less critical than others, depending on specific circumstances. Finally, a research focus on implementation demanded proactive engagement by decision-makers in conceptualizing the research and identifying opportunities for direct action by decision-makers. As the EIR approach is a novel approach in these low-resource settings, key supports are needed to build capacity of health sector stakeholders and create an enabling environment through system-level strategies. Key implications for such supports include: promoting EIR and creating incentives for decision-makers to engage in it, establishing structures or mechanisms to facilitate decision-maker involvement, allocating funds for EIR, and developing guidance for EIR practitioners.
Snow crab (Chionoecetes opilio), a new food item for North-east Arctic cod (Gadus morhua) in the Barents Sea
Authors: Holt Rebecca E , Hvingel Carsten , Agnalt Ann-Lisbeth , Dolgov Andrey V , Hjelset Ann Merete , Bogstad Bjarte 
Published: September 2020

Abstract
The snow crab (Chionoecetes opilio) is a newly established species in the Barents Sea, increasing in both distribution and abundance in recent years. We explore the potential importance of North-east Arctic cod (Gadus morhua) predation in structuring the snow crab population expansion in the Barents Sea, through an analysis of cod stomach content data from 2003 to 2018. Spatio-temporal patterns of snow crab within cod diet are assessed across years, between seasons, as well as ontogenetic trends, including predator–prey size relationships. Snow crab represents a new prey item for cod and in recent years the most dominant demersal crustacean species in cod diet. The proportion of snow crab within cod diet increases over time. Primarily 60–110 cm cod prey upon snow crab, mainly during the summer/autumn season. Our results support the idea that the snow crab is still expanding, shifting distribution north and westwards. Cod has the potential to regulate the snow crab population but is unlikely to be in direct competition with the fishery in the Barents Sea. This work suggests that cod can be used as biological sampling tools together with other monitoring programmes to elucidate how new species may affect predator–prey and food-web dynamics within an ecosystem context.
Repair of traumatic ventricular septal defect and left ventricular aneurysm after blunt chest trauma
Authors: Shi Tao , Liu Rui , Zhang Changwei , Guo Shaoxian 
Published: September 2020

Abstract
Blunt chest trauma can cause a variety of cardiac injuries, either immediately or days after the trauma. We report a case of traumatic ventricular septal defect and ribbonlike left ventricular aneurysm, which was diagnosed 15 years after the initial blunt chest trauma. It was successfully repaired using the endoventricular patch technique with a satisfactory 1-year follow-up result.
Conversion from video-assisted thoracic surgery (VATS) to thoracotomy during major lung resection: how does it affect perioperative outcomes?
Authors: Seitlinger Joseph , Olland Anne , Guinard Sophie , Massard Gilbert , Falcoz Pierre-Emmanuel 
Published: September 2020

Abstract

OBJECTIVES
Since video-assisted thoracic surgery (VATS) was first performed in the early 1990s, there have been many developments, and the conversion rate has decreased over the years. This article highlights the specific outcomes of patients undergoing conversion to thoracotomy despite initially scheduled VATS lung resection.

METHODS
We retrospectively reviewed 501 patients who underwent thoracoscopic anatomic lung resection (i.e. lobectomy, segmentectomy or bilobectomy) between 1 January 2012 and 1 August 2017 at our institution. We explored the risk factors for surgical conversion and adverse events occurring in patients who underwent conversion to thoracotomy.

RESULTS
A total of 44/501 patients underwent conversion during the procedure (global rate: 8.8%). The main reasons for conversion were (i) anatomical variation, adhesions or unexpected tumour extension (37%), followed by (ii) vascular causes (30%) and (iii) unexpected lymph node invasion (20%). The least common reason for conversion was technical failure (13%). We could not identify any specific risk factors for conversion. The global complication rate was significantly higher in converted patients (40.9%) than in complete VATS patients (16.8%) (P = 0.001). Postoperative atrial fibrillation was a major complication in converted patients (18.2%) [odds ratio (OR) 5.09, 95% confidence interval (CI) 1.80–13.27; P = 0.001]. Perioperative mortality was higher in the conversion group (6.8%) than in the VATS group (0.2%) (OR 33.3, 95% CI 3.4–328; P = 0.003).

CONCLUSIONS
Through the years, the global conversion rate has dramatically decreased to &lt;10%. Nevertheless, patients who undergo conversion represent a high-risk population in terms of complications (40.9% vs 16.8%) and perioperative mortality (6.8% vs 0.2%).
Breast Cancer Screening Recommendations: African American Women Are at a Disadvantage
Authors: Rebner Murray , Pai Vidya R 
Published: September 2020

Abstract
Since 1990, breast cancer mortality has decreased by 40% in white women but only 26% in African American women. The age at diagnosis of breast cancer is younger in black women. Breast cancer diagnosed before age 50 represents 23% of all breast cancers in African American women but only 16% of all breast cancers in white women. White women have a higher incidence of breast cancer over the age of 60. Tumor subtypes also vary among racial and ethnic groups. The triple-negative (TN) subtype, which has a poorer outcome and occurs at a younger age, represents 21% of invasive breast cancers in black women but only 10% of invasive breast cancers in white women. The hormone receptor–positive subtype, which is more common in older women and has the best outcome, has a higher incidence in white women (70%) than in black women (61%). The BRCA2 mutation is also more common in black women than in white women (other than those who are of Ashkenazi Jewish ancestry). There are also many barriers to screening. Major ones include the lack of contact with a primary health care provider as well as a decreased perceived risk of having breast cancer in the African American population. Given the younger age of onset and the higher incidence of the TN molecular subtype, following breast cancer screening guidelines that do not support screening before the age of 50 may disadvantage black women.
An overview of the medical-physics-related verification system for radiotherapy multicenter clinical trials by the Medical Physics Working Group in the Japan Clinical Oncology Group–Radiation Therapy Study Group
Authors: Nishio Teiji , Nakamura Mitsuhiro , Okamoto Hiroyuki , Kito Satoshi , Minemura Toshiyuki , Ozawa Shuichi , Kumazaki Yu , Ishikawa Masayori , Tohyama Naoki , Kurooka Masahiko , Nakashima Takeo , Shimizu Hidetoshi , Suzuki Ryusuke , Ishikura Satoshi , Nishimura Yasumasa 
Published: September 2020

Abstract
The Japan Clinical Oncology Group–Radiation Therapy Study Group (JCOG-RTSG) has initiated several multicenter clinical trials for high-precision radiotherapy, which are presently ongoing. When conducting multi-center clinical trials, a large difference in physical quantities, such as the absolute doses to the target and the organ at risk, as well as the irradiation localization accuracy, affects the treatment outcome. Therefore, the differences in the various physical quantities used in different institutions must be within an acceptable range for conducting multicenter clinical trials, and this must be verified with medical physics consideration. In 2011, Japan’s first Medical Physics Working Group (MPWG) in the JCOG-RTSG was established to perform this medical-physics-related verification for multicenter clinical trials. We have developed an auditing method to verify the accuracy of the absolute dose and the irradiation localization. Subsequently, we credentialed the participating institutions in the JCOG multicenter clinical trials that were using stereotactic body radiotherapy (SBRT) for lungs, intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for several disease sites, and proton beam therapy (PT) for the liver. From the verification results, accuracies of the absolute dose and the irradiation localization among the participating institutions of the multicenter clinical trial were assured, and the JCOG clinical trials could be initiated.
Evolution of the United States Military Extracorporeal Membrane Oxygenation Transport Team
Authors: Read Matthew D , Nam Jason J , Biscotti Mauer , Piper Lydia C , Thomas Sarah B , Sams Valerie G , Elliott Bernadette S , Negaard Kathryn A , Lantry James H , DellaVolpe Jeffry D , Batchinsky Andriy , Cannon Jeremy W , Mason Phillip E 
Published: September 2020

Abstract

Introduction
The use of extracorporeal membrane oxygenation (ECMO) for the care of critically ill adult patients has increased over the past decade. It has been utilized in more austere locations, to include combat wounded. The U.S. military established the Acute Lung Rescue Team in 2005 to transport and care for patients unable to be managed by standard medical evacuation resources. In 2012, the U.S. military expanded upon this capacity, establishing an ECMO program at Brooke Army Medical Center. To maintain currency, the program treats both military and civilian patients.

Materials and methods
We conducted a single-center retrospective review of all patients transported by the sole U.S. military ECMO program from September 2012 to December 2019. We analyzed basic demographic data, ECMO indication, transport distance range, survival to decannulation and discharge, and programmatic growth.

Results
The U.S. military ECMO team conducted 110 ECMO transports. Of these, 88 patients (80%) were transported to our facility and 81 (73.6%) were cannulated for ECMO by our team prior to transport. The primary indication for ECMO was respiratory failure (76%). The range of transport distance was 6.5 to 8,451 miles (median air transport distance = 1,328 miles, median ground transport distance = 16 miles). In patients who were cannulated remotely, survival to decannulation was 76% and survival to discharge was 73.3%.

Conclusions
Utilization of the U.S. military ECMO team has increased exponentially since January 2017. With an increased tempo of transport operations and distance of critical care transport, survival to decannulation and discharge rates exceed national benchmarks as described in ELSO published data. The ability to cannulate patients in remote locations and provide critical care transport to a military medical treatment facility has allowed the U.S. military to maintain readiness of a critical medical asset.
Black hole, neutron star, and white dwarf merger rates in AGN discs
Authors: McKernan B , Ford K E S , O’Shaughnessy R 
Published: September 2020

ABSTRACT
Advanced LIGO and Advanced Virgo are detecting a large number of binary stellar origin black hole (BH) mergers. A promising channel for accelerated BH merger lies in active galactic nucleus (AGN) discs of gas around supermasssive BHs. Here, we investigate the relative number of compact object (CO) mergers in AGN disc models, including BH, neutron stars (NS), and white dwarfs, via Monte Carlo simulations. We find the number of all merger types in the bulk disc grows ∝ t1/3 which is driven by the Hill sphere of the more massive merger component. Median mass ratios of NS–BH mergers in AGN discs are $\tilde{q}=0.07\pm 0.06(0.14\pm 0.07)$ for mass functions (MF) M−1(− 2). If a fraction fAGN of the observed rate of BH–BH mergers (RBH–BH) come from AGN, the rate of NS–BH (NS–NS) mergers in the AGN channel is ${R}_{\mathrm{ BH}\!-\!\mathrm{ NS}} \sim f_{\mathrm{ AGN}}[10,300]\, \rm {Gpc}^{-3}\, \rm {yr}^{-1},({\mathit{ R}}_{NS\!-\!NS} \le \mathit{ f}_{AGN}400\, \rm {Gpc}^{-3}\, \rm {yr}^{-1}$). Given the ratio of NS–NS/BH–BH LIGO search volumes, from preliminary O3 results the AGN channel is not the dominant contribution to observed NS–NS mergers. The number of lower mass gap events expected is a strong function of the nuclear MF and mass segregation efficiency. CO merger ratios derived from LIGO can restrict models of MF, mass segregation, and populations embedded in AGN discs. The expected number of electromagnetic (EM) counterparts to NS–BH mergers in AGN discs at z &lt; 1 is $\sim [30,900]\, {\rm {yr}}^{-1}(f_{\mathrm{ AGN}}/0.1)$. EM searches for flaring events in large AGN surveys will complement LIGO constraints on AGN models and the embedded populations that must live in them.