bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive effects of personal resources and job characteristics on mental health: a population-based panel study
Authors: Limmer Anja , Schütz Astrid 
Published: June 2020

Abstract
Purpose
We examined 10 job characteristics in a large population-based sample and tested for positive and negative effects on mental health. In addition, we tested for possible effects on mental health from interactions with locus of control and self-esteem.

Methods
The sample comprised longitudinal data on 2353 male and 1960 female employees from the German socio-economic panel collected between 2010 and 2012. Mental health was assessed with the mental component summary score derived from the short-form 12 health survey. We computed hierarchical regression analyses while controlling for potential confounds and baseline mental health. Interaction effects were specified with post hoc simple slope analyses.

Results
Time pressure, interruptions, job insecurity, and conflicts were negative predictors of mental health in all models. The personal resource of self-esteem was a positive predictor. Moreover, there were interactions: opportunities for promotion were beneficial only for employees with medium or high levels of self-esteem, whereas the contrary was true for employees with very low self-esteem. Working on weekends was negatively related to mental health for people with moderate to low internal control but not for people with high internal control.

Conclusions
The findings suggest that there are job demands that are related to poor mental health regardless of personal resources. These aspects are important to consider in workplace risk assessment. By contrast, with other job characteristics (e.g., opportunities for promotion, weekend work), the effects vary between individuals.
An exploration of methods for obtaining 0 = dead anchors for latent scale EQ-5D-Y values
Authors: Shah Koonal K. , Ramos-Goñi Juan Manuel , Kreimeier Simone , Devlin Nancy J. 
Published: June 2020

Abstract
Objectives
Discrete choice experiments (DCEs) can be used to obtain latent scale values for the EQ-5D-Y, but these require anchoring at 0 = dead to meet the conventions of quality-adjusted life year (QALY) estimation. The primary aim of this study is to compare four preference elicitation methods for obtaining anchors for latent scale EQ-5D-Y values.

Methods
Four methods were tested: visual analogue scale (VAS), DCE (with a duration attribute), lag-time time trade-off (TTO) and the location-of-dead (LOD) approach. In computer-assisted personal interviews, UK general public respondents valued EQ-5D-3L health states from an adult perspective and EQ-5D-Y health states from a 10-year-old child perspective. Respondents completed valuation tasks using all four methods, under both perspectives.

Results
349 interviews were conducted. Overall, respondents gave lower values under the adult perspective compared to the child perspective, with some variation across methods. The mean TTO value for the worst health state (33333) was about equal to dead in the child perspective and worse than dead in the adult perspective. The mean VAS rescaled value for 33333 was also higher in the child perspective. The DCE produced positive child perspective values and negative adult perspective values, though the models were not consistent. The LOD median rescaled value for 33333 was negative under both perspectives and higher in the child perspective.

Discussion
There was broad agreement across methods. Potential criteria for selecting a preferred anchoring method are presented. We conclude by discussing the decision-making circumstances under which utilities and QALY estimates for children and adults need to be commensurate to achieve allocative efficiency.
Reading for entertainment or information reception? Gender differences in reading preferences and their impact on text-type-specific reading competences in adult readers
Authors: Thums Kathrin , Artelt Cordula , Wolter Ilka 
Published: June 2020

AbstractThis study aims at exploring gender differences in text-type-specific reading competences via readers’ gender-specific reading preferences. Women were expected to read more often for the sake of entertainment (entertainment preference), whereas men were expected to read more often to gain information (information preference). We further assumed that individuals who read for entertainment would have higher reading competence in fictional literary texts compared with non-fictional informational texts, and vice versa for individuals who read to gain information. The analysis was based on a sample of 830 adults between 19 and 71 years (M = 31.04; SD = 12.53) from a pilot study of the German National Educational Panel Study (NEPS). A structural equation model confirmed that women and men show different reading preferences during leisure time. The preference to read for entertainment was predictive for reading competence in literary texts; however, the preference to read for information had positive effects on reading competence in both informational and literary texts.
RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain
Authors: Bridges Esther , Sheldon Helen , Kleibeuker Esther , Ramberger Evelyn , Zois Christos , Barnard Alun , Harjes Ulrike , Li Ji-Liang , Masiero Massimo , MacLaren Robert , Harris Adrian 
Published: June 2020

AbstractAngiogenesis, the formation of new blood vessels by endothelial cells, is a finely tuned process relying on the balance between promoting and repressing signalling pathways. Among these, Notch signalling is critical in ensuring appropriate response of endothelial cells to pro-angiogenic stimuli. However, the downstream targets and pathways effected by Delta-like 4 (DLL4)/Notch signalling and their subsequent contribution to angiogenesis are not fully understood. We found that the Rho GTPase, RHOQ, is induced by DLL4 signalling and that silencing RHOQ results in abnormal sprouting and blood vessel formation both in vitro and in vivo. Loss of RHOQ greatly decreased the level of Notch signalling, conversely overexpression of RHOQ promoted Notch signalling. We describe a new feed-forward mechanism regulating DLL4/Notch signalling, whereby RHOQ is induced by DLL4/Notch and is essential for the NICD nuclear translocation. In the absence of RHOQ, Notch1 becomes targeted for degradation in the autophagy pathway and NICD is sequestered from the nucleus and targeted for degradation in lysosomes.
The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration
Authors: Zhang Xiaolu , Blockhuys Stéphanie , Devkota Ranjan , Pilon Marc , Wittung-Stafshede Pernilla 
Published: June 2020

AbstractCell migration is a fundamental biological process involved in for example embryonic development, immune system and wound healing. Cell migration is also a key step in cancer metastasis and the human copper chaperone Atox1 was recently found to facilitate this process in breast cancer cells. To explore the role of the copper chaperone in other cell migration processes, we here investigated the putative involvement of an Atox1 homolog in Caenorhabditis elegans, CUC-1, in distal tip cell migration, which is a key process during the development of the C. elegans gonad. Using knock-out worms, in which the cuc-1 gene was removed by CRISPR-Cas9 technology, we probed life span, brood size, as well as distal tip cell migration in the absence or presence of supplemented copper. Upon scoring of gonads, we found that cuc-1 knock-out, but not wild-type, worms exhibited distal tip cell migration defects in approximately 10–15% of animals and, had a significantly reduced brood size. Importantly, the distal tip cell migration defect was rescued by a wild-type cuc-1 transgene provided to cuc-1 knock-out worms. The results obtained here for C. elegans CUC-1 imply that Atox1 homologs, in addition to their well-known cytoplasmic copper transport, may contribute to developmental cell migration processes.
Psychosocial and Clinical Profiles of the Cases Visiting the Emergency Department Due to Accidental Self-harm and Suicide Attempts in Doha, Qatar: A Retrospective Study
Authors: Al-Amin Hassen , Singh Rajvir , Abdulrazzak Mohamad , Ghuloum Suhaila 
Published: June 2020

AbstractThe aims of this study were to retrospectively assess the profiles of subjects with suicide attempts and self-harm in Doha, Qatar; and whether the available data were complete. We reviewed all the records of fatal and non-fatal suicides together with accidental self-ham cases seen in the major Emergency Department in Doha, over a one-year period. There was 37 completed suicide, mostly male expatriates in mid 30 s who died by hanging. In cases with suicide intent (N = 270), more males were admitted to Psychiatry than women. Overdose was the common method and the majority had mood disorders. In self-harm cases with no suicide intent (N = 150) the majority were not seen by Psychiatry. The profiles of suicide cases in Qatar are similar to those reported internationally. However, there is a major need to establish a comprehensive system to register and assess all self-harm patients in Qatar.
Indications for intraoperative anterior segment optical coherence tomography in corneal surgery
Authors: Lang Stefan J. , Heinzelmann Sonja , Böhringer Daniel , Reinhard Thomas , Maier Philip 
Published: June 2020

Abstract
Purpose
Recently, intraoperative optical coherence tomography (iOCT) has evolved in the field of ophthalmic surgery. So far, the use of iOCT was mainly focused to lamellar keratoplasty, especially deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK). The aim of this study was to report our experiences with iOCT to introduce new possibilities of this application.

Methods
We used iOCT in 18 patients who underwent the following surgeries: DALK, DMEK, penetrating keratoplasty, autologous limbal transplantation, transscleral suture fixation of a posterior chamber lens, pannus removal on corneal surface and newborn investigation in Peters’ anomaly. We obtained qualitative video data for all procedures.

Results
With the iOCT, the cannula placement during DALK preparation of the recipient cornea and bubble formation could be visualized to improve the success rate of the big bubble injection. In DMEK, the iOCT enables the visualization of Descemet’s membrane removal in the recipient and graft orientation as well as better control of graft attachment. The iOCT enables intraoperative visualization of the graft–host interface during penetrating keratoplasty. During autologous limbal transplantation, transscleral suture fixation of a posterior chamber lens and removal of corneal surface pannus the iOCT is capable of showing the thickness of lamellar preparations to avoid penetrations and to save healthy recipient’s tissue.

Conclusion
The iOCT is a helpful device for intraoperative anterior segment imaging not only for DALK and DMEK. It is also beneficial in penetrating keratoplasty and every other form of lamellar preparation during corneoscleral surgery.
Punctures and p-Spin Curves from Matrix Models
Authors: Brézin E. , Hikami S. 
Published: June 2020

AbstractThis article investigates the intersection numbers of the moduli space of p-spin curves with the help of matrix models. The explicit integral representations that are derived for the generating functions of these intersection numbers exhibit p Stokes domains, labelled by a “spin”-component l taking values $$l = -1, 0, 1, 2,...,p-2$$

l
=
-
1
,
0
,
1
,
2
,
.
.
.
,
p
-
2

. Earlier studies concerned integer values of p, but the present formalism allows one to extend our study to half-integer or negative values of p, which turn out to describe new types of punctures or marked points on the Riemann surface. They fall into two classes: Ramond $$(l=-1)$$

(
l
=
-
1
)

, absent for positive integer p, and Neveu–Schwarz $$(l\ne -1)$$

(
l
≠
-
1
)

. The intersection numbers of both types are computed from the integral representation of the n-point correlation functions in a large N scaling limit. We also consider a supersymmetric extension of the random matrix formalism to show that it leads naturally to an additional logarithmic potential. Open boundaries on the surface, or admixtures of R and NS punctures, may be handled by this extension.
Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer
Authors: Malani Rachna , Fleisher Martin , Kumthekar Priya , Lin Xuling , Omuro Antonio , Groves Morris D. , Lin Nancy U. , Melisko Michelle , Lassman Andrew B. , Jeyapalan Suriya , Seidman Andrew , Skakodub Anna , Boire Adrienne , DeAngelis Lisa M. , Rosenblum Marc , Raizer Jeffrey , Pentsova Elena 
Published: June 2020

Abstract
Purpose
The CellSearch® system has been used to identify circulating tumor cells (CTCs) in cerebrospinal fluid (CSF) to diagnose leptomeningeal metastasis (LM) in patients with epithelial cancers. Using this system, we prospectively explored sequential CSF CTC enumeration in patients with LM from HER2+ cancers receiving intrathecal (IT) trastuzumab to capture dynamic changes in CSF CTC enumeration.

Methods
CSF from patients enrolled in an IRB-approved phase I/II dose escalation trial of IT trastuzumab for LM in HER2+ cancer (NCT01325207) was obtained on day 1 of each cycle and was evaluated by the CellSearch® platform for CTC enumeration. The results were correlated with CSF cytology from the same sample, along with clinical and radiographic response.

Results
Fifteen out of 34 patients with HER2+ LM were enrolled in CSF CTC analysis; 14 were women. Radiographic LM was documented in 14 (93%) patients; CSF cytology was positive in 6 (40%) and CSF CTCs were identified in 13 (87%). Median CSF CTC was 22 CTCs (range 0–200 +) per 3 ml. HER2/neu expression analysis of CTCs was performed in 8 patients; 75% had confirmed expression of HER2/neu positivity in CSF and HER2/neu expression was absent in 25%. Four of 10 patients received 7 or more cycles of IT trastuzumab; in 3 of these patients, increase in CSF CTCs enumeration from baseline was detected 2–3 months prior to changes seen on MRI, and while CSF cytology remained negative.

Conclusion
Our study demonstrates that enumeration of CSF CTCs may provide dynamic, quantitative assessment of tumor burden in the central nervous system compartment during treatment for LM and prior to changes on MRI or CSF cytology.
Trial Registration: Clinicaltrials.gov: NCT01325207; registered March 29th, 2011.
When the Window Cracks: Transparency and the Fractured Self in Depersonalisation
Authors: Ciaunica Anna , Charlton Jane , Farmer Harry 
Published: June 2020

AbstractThere has recently been a resurgence of philosophical and scientific interest in the foundations of self-consciousness, with particular focus on its altered, anomalous forms. This paper looks at the altered forms of self-awareness in Depersonalization Disorder (DPD), a condition in which people feel detached from their self, their body and the world (Derealisation). Building upon the phenomenological distinction between reflective and pre-reflective self-consciousness, we argue that DPD may alter thetransparencyof basic embodied forms of pre-reflective self-consciousness, as well as the capacity to flexibly modulate and switch between the reflective and pre-reflective facets of self-awareness. Empirical evidence will be invoked in support of the idea that impaired processing of bodily signals is characteristic of the condition. We provide first-hand subjective reports describing the experience of self-detachment or fracture between an observing and an observed self. This split is compared with similar self-detachment phenomena reported in certain Buddhist-derived meditative practices. We suggest that these alterations and changes may reveal the underlying and tacit transparency that characterises the embodied and basic pre-reflective forms of self-consciousness, in the same way that a crack in a transparent glass may indicate the presence of an unnoticed window.
Plant cell (Brassica napus) response to europium(III) and uranium(VI) exposure
Authors: Moll Henry , Sachs Susanne , Geipel Gerhard 
Published: June 2020

AbstractExperiments conducted over a period of 6 weeks using Brassica napus callus cells grown in vitro under Eu(III) or U(VI) stress showed that B. napus cells were able to bioassociate both potentially toxic metals (PTM), 628 nmol Eu/gfresh cells and 995 nmol U/gfresh cells. Most of the Eu(III) and U(VI) was found to be enriched in the cell wall fraction. Under high metal stress (200 μM), cells responded with reduced cell viability and growth. Subsequent speciation analyses using both metals as luminescence probes confirmed that B. napus callus cells provided multiple-binding environments for Eu(III) and U(VI). Moreover, two different inner-sphere Eu3+ species could be distinguished. For U(VI), a dominant binding by organic and/or inorganic phosphate groups of the plant biomass can be concluded.
At the Junction: Two Models of Business Responsibility for Modern Slavery
Authors: Mende Janne , Drubel Julia 
Published: June 2020

AbstractThis article develops a conceptual pattern of the reasons and scope of business responsibility for modern slavery. It introduces modern slavery as either relation or structure and designs an understanding of a broad and a narrow model of business responsibility, consisting of business power, internal and external realms of business conduct and public and private roles of companies. Crossing the two models of modern slavery with the two models of business responsibility, the article carves out the strengths and limits of their junctions. The continuous pendulum between the junctions allows to discuss how and why companies can be responsible for modern slavery. It thus contributes analytically, practically and normatively to tackling modern slavery.
Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles
Authors: Wojcieszak Jakub , Kuczyńska Katarzyna , Zawilska Jolanta B. 
Published: June 2020

AbstractTwo chloromethcathinones, 3-chloromethcathinone (3-CMC) and 4-chloromethcathinone (4-CMC), and two para-substituted α-pyrrolidinophenones, 4-methoxy-α-pyrrolidinopentiophenone (4-MeO-PVP) and 4-fluoro-α-pyrrolidinopentiophenone (4-F-PVP), represent synthetic cathinones, the second most frequently abused group of new psychoactive substances (NPSs), which has aroused a worldwide health concern in the last decade. Synthetic cathinones act as psychostimulants by elevating extracellular levels of monoaminergic neurotransmitters. This study investigates effects of 3-CMC, 4-CMC, 4-MeO-PVP, and 4-F-PVP on the spontaneous locomotor activity and motor performance of mice. Additionally, neurotoxicity of substituted methcathinones against SH-SY5Y neuroblastoma cells was evaluated. All test cathinones stimulate in a dose-dependent manner horizontal locomotor activity of mice. Consistently to our prior findings, pyrrovalerones, but not methcathinone derivatives, produce dose-dependent elevation of vertical locomotor activity (rearing behavior). None of the tested compounds decreases the time spent on the accelerating rotarod, pointing to the lack of considerable motor disability in mice after acute exposition. Only 4-MeO-PVP at the high tested dose (20 mg/kg) increases motor performance of mice. Considering that α-pyrrolidinophenones are highly potent and selective DA uptake inhibitors, while chloromethcathinones enhance non-selective DA/5-HT release, we suggest that the increase of vertical locomotor activity and performance on rotarod in mice may serve as a behavioral indicator of the monoaminergic profile of synthetic cathinones. Finally, this study gives first insights into cytotoxicity of both 3-CMC and 4-CMC displayed against SH-SY5Y cells, which emerges and intensifies after prolonged incubation, suggesting the indirect mechanism of action, unrelated to interactions with monoamine transporters.
Valsartan metal complexes as capture and reversible storage media for methane
Authors: Najim Liqaa H. , El-Hiti Gamal A. , Ahmed Dina S. , Mohammed Alaa , Alotaibi Mohammad Hayal , Yousif Emad 
Published: June 2020

AbstractThree valsartan metal (tin, nickel, and magnesium) complexes were examined as capture and storage media for methane under high temperature (323 K) and pressure (50 bar) conditions. The surface morphology of the complexes were examined using Field emission scanning electron microscopy and displayed porous structures comprising particles of different shapes and sizes. The narrow pore-size distribution of metal complexes makes them suitable materials for methane capture. The methane adsorption–desorption isotherms of the metal complexes were reversible. The tin(IV) and nickel(II) complexes exhibited type-III physisorption isotherms, while the magnesium(II) complex displayed a type-IV physisorption isotherm. Both types of isotherms are typical for mesoporous materials. The magnesium(II) complex was more efficient compared with the tin(IV) and nickel(II) complexes. It exhibited a remarkable methane uptake capacity of 71.68 cm3/g under optimized conditions.
Implication of nanostructuring of bulk nanocomposite Ti9Ni7Sn8 on the optimization of high thermoelectric performance
Authors: Kumar Ashish , Chaturvedi K. M. , Bhardwaj A. , Govind Bal , Bano Sahiba , Misra D. K. 
Published: June 2020

AbstractNanostructuring approach on TiNiSn-based half-Heusler (HH) thermoelectric materials (TE) has been well established as the most prominent paradigm for achieving high figure of merit (ZT). Herein, we have extended this approach on our previously reported bulk nanocomposite (BNC), containing HH and Full Heusler (FH) with little traces of Ti6Sn5 phase in a stoichiometric composition Ti9Ni7Sn8 for the optimization of high thermoelectric performance. A synergistic effect of nanostructuring of Ti9Ni7Sn8 bulk nanocomposite (BNC) on its thermoelectric properties was noticed, revealing an enhanced value of ZT ~ 0.83 at 773 K. This enhancement in ZT value is mainly ascribed to significant reduction in thermal conductivity (κ ~ 1.0 W/mK at 773 K), through modification in grain as well as phase boundary scattering. The marginal enhancement in Seebeck coefficient observed is attributed to charge carrier filtering effect at the interface of HH/FH phases.
Clinical audit on World Health Organization surgical safety checklist completion at Debre Berhan comprehensive specialized hospital: A prospective cohort study
Authors: Allene Mengesha Dessie 
Published: June 2020

ABSTRACT

Background:
Surgical care is an integral part of health care throughout the world. Surgical complications are occurred in 3–16% of surgical procedures. The WHO surgical safety checklist outlines essential standards of surgical care and has been shown to reduce complications and death associated with surgery. Thus, the aim of this study is to assess the proper completion of the World Health Organization (WHO) surgical safety checklist.

Method:
A prospective observational study was conducted among 255 patients undergoing elective and emergency surgery from October 03, 2020 to March 28, 2020. Completeness rate of Sign-in, Time-out, and Sign-out domains was computed with SPSS 22.0 package.

Result:
During a period of six months, in our study, we only included the completion of 255 patients' checklist that undergo major operations were included in our study. Confirming patients’ identity, procedure and consent was completed in all patients (100%); the safety of anaesthesia machine and medications were check for all patients. Essential images were not displayed in all patients (100% missed).

Conclusion:
Overall completeness of the checklist in the sign in, time out and sign out period was good. The present study did not assess outcomes, but it is assumed that poor completeness puts patients at risk of perioperative complications.

Highlights: