bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on sleep apnea in patients with abnormal sewda type of depression
Authors: Gul Aman , Memtily Nassirhadjy , Mijit Pirdun , Wushuer Palidan , Talifu Ainiwaer , Imin Mihriban , Rui Hua , Nuermaimaiti Zuhoumaer 
Published: October 2020

Objective: To preliminarily investigate the clinical features and PSG in abnormal sewda-type depressive insomnia. Methods: A total of 127 abnormal sewda-type depressive insomnia patients were evaluated with overnight PSG, and 32 normal participants were compared. Results: Patients with abnormal sewda-type depressive insomnia were compared with the control group; the sleep symptoms showed a long incubation period of sleep, low sleep maintenance rate, low sleep efficiency and poor sleep quality as well as daytime dysfunction. At process and continuity of sleep: Total sleep time, sleep efficiency, sleep maintenance rate in abnormal sewda-type depressive insomnia group were shorter than the control group. Wake after sleep onset, and sleep latency were longer than the control group. At sleep structure: N1 ratio and N2 ratio in depressive insomnia group were longer than the control group, N3 ratio and REM sleep ratio shorter than the control group. At REM index: REM latency, REM cycles, and REM sleep time were shorter than the control group. Conclusion: Insomnia symptoms in abnormal sewda-type depression comorbid insomnia patients were similar to the ordinary insomnia patients. The PSG characteristics had significant changes in sleep process, sleep structure and REM indicators. The severity of the abnormal sewda-type depression was closely related to REM indicators. Change of REM sleep characteristics may be the specificity, and these could be taken as reference in diagnosis and identification of abnormal sewda-type depressive insomnia.
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition
Authors: Binkley Michael S. , Jeon Young-Jun , Nesselbush Monica , Moding Everett J. , Nabet Barzin Y. , Almanza Diego , Kunder Christian , Stehr Henning , Yoo Christopher H. , Rhee Siyeon , Xiang Michael , Chabon Jacob J. , Hamilton Emily , Kurtz David M. , Gojenola Linda , Owen Susie Grant , Ko Ryan B. , Shin June Ho , Maxim Peter G. , Lui Natalie S. , Backhus Leah M. , Berry Mark F. , Shrager Joseph B. , Ramchandran Kavitha J. , Padda Sukhmani K. , Das Millie , Neal Joel W. , Wakelee Heather A. , Alizadeh Ash A. , Loo Billy W. , Diehn Maximilian 
Published: October 2020

Abstract

Tumor genotyping is not routinely performed in localized non–small cell lung cancer (NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 consecutive patients with localized NSCLC and demonstrate that KEAP1 and NFE2L2 mutations are predictive of high rates of local recurrence (LR) after radiotherapy but not surgery. Half of LRs occurred in tumors with KEAP1/NFE2L2 mutations, indicating that they are major molecular drivers of clinical radioresistance. Next, we functionally evaluate KEAP1/NFE2L2 mutations in our radiotherapy cohort and demonstrate that only pathogenic mutations are associated with radioresistance. Furthermore, expression of NFE2L2 target genes does not predict LR, underscoring the utility of tumor genotyping. Finally, we show that glutaminase inhibition preferentially radiosensitizes KEAP1-mutant cells via depletion of glutathione and increased radiation-induced DNA damage. Our findings suggest that genotyping for KEAP1/NFE2L2 mutations could facilitate treatment personalization and provide a potential strategy for overcoming radioresistance conferred by these mutations.

Significance:
This study shows that mutations in KEAP1 and NFE2L2 predict for LR after radiotherapy but not surgery in patients with NSCLC. Approximately half of all LRs are associated with these mutations and glutaminase inhibition may allow personalized radiosensitization of KEAP1/NFE2L2-mutant tumors.
This article is highlighted in the In This Issue feature, p. 1775
Activities related to inflammatory bowel disease management during and after the coronavirus disease 2019 lockdown in Italy: How to maintain standards of care
Authors: Saibeni Simone , Scucchi Ludovica , Dragoni Gabriele , Bezzio Cristina , Miranda Agnese , Ribaldone Davide Giuseppe , Bertani Angela , Bossa Fabrizio , Allocca Mariangela , Buda Andrea , Mocci Gianmarco , Soriano Alessandra , Mazzuoli Silvia , Bertani Lorenzo , Baccini Flavia , Loddo Erika , Privitera Antonino Carlo , Sartini Alessandro , Viscido Angelo , Grossi Laurino , Casini Valentina , Gerardi Viviana , Ascolani Marta , Di Ruscio Mirko , Casella Giovanni , Savarino Edoardo , Stradella Davide , Pumpo Rossella , Cortelezzi Claudio Camillo , Daperno Marco , Ciardo Valeria , Nardone Olga Maria , Caprioli Flavio , Vitale Giovanna , Cappello Maria , Comberlato Michele , Alvisi Patrizia , Festa Stefano , Campigotto Michele , Bodini Giorgia , Balestrieri Paola , Viola Anna , Pugliese Daniela , Armuzzi Alessandro , Fantini Massimo C , Fiorino Gionata ,   IG‐IBD (Italian Group for the study of Inflammatory Bowel Disease)
Published: October 2020

Background and aimsRestructuring activities have been necessary during the lockdown phase of the coronavirus disease 2019 (COVID‐19) pandemic. Few data are available on the post‐lockdown phase in terms of health‐care procedures in inflammatory bowel disease (IBD) care, and no data are available specifically from IBD units. We aimed to investigate how IBD management was restructured during the lockdown phase, the impact of the restructuring on standards of care and how Italian IBD units have managed post‐lockdown activities.MethodsA web‐based online survey was conducted in two phases (April and June 2020) among the Italian Group for IBD affiliated units within the entire country. We investigated preventive measures, the possibility of continuing scheduled visits/procedures/therapies because of COVID‐19 and how units resumed activities in the post‐lockdown phase.ResultsForty‐two referral centres participated from all over Italy. During the COVID‐19 lockdown, 36% of first visits and 7% of follow‐up visits were regularly done, while >70% of follow‐up scheduled visits and 5% of first visits were done virtually. About 25% of scheduled endoscopies and bowel ultrasound scans were done. More than 80% of biological therapies were done as scheduled. Compared to the pre‐lockdown situation, 95% of centres modified management of outpatient activity, 93% of endoscopies, 59% of gastrointestinal ultrasounds and 33% of biological therapies. Resumption of activities after the lockdown phase may take three to six months to normalize. Virtual clinics, implementation of IBD pathways and facilities seem to be the main factors to improve care in the future.ConclusionItalian IBD unit restructuring allowed quality standards of care during the COVID‐19 pandemic to be maintained. A return to normal appears to be feasible and achievable relatively quickly. Some approaches, such as virtual clinics and identified IBD pathways, represent a valid starting point to improve IBD care in the post‐COVID‐19 era.
White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile
Authors: Ohta Haruhisa , Aoki Yuta Y. , Itahashi Takashi , Kanai Chieko , Fujino Junya , Nakamura Motoaki , Kato Nobumasa , Hashimoto Ryu-ichiro 
Published: October 2020

Abstract
Background
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain–sensory relationships are either shared between or distinct to ASD and ADHD.

Methods
We collected DTI data from adult population with DD (a primary diagnosis of ASD: n = 105, ADHD: n = 55) as well as age- and sex-matched typically developing (TD) participants (n = 58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD) were analyzed using tract-based spatial statistics. The severities of sensory symptoms were assessed using the Adolescent/Adult Sensory Profile (AASP).

Results
Categorical analyses identified voxel clusters showing significant effects of DD on FA and RD in the posterior portion of the corpus callosum and its extension in the right hemisphere. Furthermore, regression analyses using the AASP scores revealed that slopes in relationships of FA or RD with the degree of sensory symptoms were parallel between the two DDs in large parts of the affected corpus callosum regions. A small but significant cluster did exist showing difference in association between an AASP subscale score and RD across ASD and ADHD.

Limitations
Wide age range of the participants may be oversimplified.

Conclusions
These results indicate that white matter alteration and their relationships to sensory symptoms are largely shared between ASD and ADHD, with localized abnormalities showing significant between-diagnosis differences within DD.
Ureteroiliac artery fistula caused by full-length metallic ureteral stenting in a malignant ureteral obstruction: a case report
Authors: Miyauchi Yasuyuki , Osaki Yu , Naito Hirohito , Tsunemori Hiroyuki , Itoh Megumi , Kanenishi Kenji , Norikane Takashi , Sanomura Takayuki , Nishiyama Yoshihiro , Sugimoto Mikio 
Published: October 2020

Abstract
Background
The metallic stent is a new device for relieving the urinary tract in patients with malignant ureteral obstruction with short life expectancy and has been used frequently worldwide for its efficacy and safety. A ureteroarterial fistula with indwelling ureteral stent is rare but highly fatal, and there are several reports of ureteroarterial fistula treated by conventional polymer stents, although there are no reports on metallic stents. To our knowledge, this paper describes the first case of a ureteroiliac artery fistula caused by a full-length metallic ureteral stent in malignant ureteral obstruction.

Case presentation
Our patient was a 57-year-old Asian woman with a history of locally advanced cervical cancer who underwent abdominal total hysterectomy and chemoradiotherapy. She was diagnosed with right hydronephrosis and hydroureter secondary to upper ureteral obstruction because of retroperitoneal lymph node metastasis. A urinary tract obstruction after placement of 12 months of polymer stent followed by 18 months of metallic stent was relieved, consequently resulting in intermittent gross hematuria with bladder tamponade and anemia. Contrast-enhanced computed tomography could not reveal a ureteroarterial fistula; however, retrograde pyelography emphasized the existence of a ureteroiliac artery fistula. The patient underwent successful endovascular heparin-bonded stent graft placement, and her gross hematuria disappeared thereafter.

Conclusion
The metallic stent is a useful device for patients with malignant ureteral obstruction with a short life expectancy, although it may impose a higher pressure on the extraureteral tissue than conventional polymer stents due to its properties and may cause a ureteroarterial fistula. The narrowing of the external iliac artery diameter visualized by computed tomography may be helpful for predicting ureteroarterial fistulas.
In search of Humboldt’s colors: materials and techniques of a 17th-century lacquered gourd from Colombia
Authors: Pozzi Federica , Basso Elena , Katz Monica 
Published: October 2020

Abstract
In 2014 the Hispanic Society Museum & Library, New York, acquired a viceregal Spanish American lacquered gourd, dating to 17th-century Colombia, which was decorated using an indigenous technique known as barniz de Pasto. This technique employs local, raw materials, including natural dyes and a plant resin commonly known as mopa mopa, harvested from Elaeagia pastoensis Mora trees that grow in the Andean rainforest. An in-depth scientific study of the gourd aimed at determining its materials and manufacturing techniques, and at comparing the results with the description of local botanical species reported by Alexander von Humboldt, the German naturalist and explorer, in the account of his travels through the region in 1801. The use of several non-invasive techniques was followed by micro-sampling. Initially, X-ray fluorescence (XRF) analysis was performed to evaluate the possible presence of inorganic pigments, while fiber optics reflectance spectroscopy (FORS) and multiband imaging provided preliminary data concerning the colorants. Dyes and pigments were fully characterized using Raman spectroscopy and high-performance liquid chromatography with photodiode array detector (HPLC-PDA); a detailed description of the resin was obtained with HPLC-PDA and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS); the metallic elements and overall decoration were analyzed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDS). Radiocarbon dating completed the technical information on the object. This work confirmed the identity of the resin as Elaeagia pastoensis Mora, supporting an unequivocal classification of the gourd as a barniz de Pasto object; the color palette was found to include some of the pigments listed by Humboldt, but also comprised other materials, such as calomel, a rare white pigment based on mercury(I) chloride; examination of the decoration’s intricate stratigraphy provided insight into the complexity of the barniz de Pasto technique, in which silver leaf is typically applied on top of a sheet of untinted resin and covered with a variable number of dyed resin layers; finally, a pre-1650 date was firmly established for the gourd, which is in line with stylistic observations that had tentatively placed this object in the early barniz de Pasto period. In addition to providing conservators with the proper tools to preserve similar lacquered objects, the wealth of knowledge gleaned from this study has revealed fascinating details about the technique employed, demonstrating the extraordinary skill and craftsmanship of the artisans involved in the lacquer arts.
Identifying important habitats for waterbird conservation at a Greek Regional Nature Park
Authors: Liordos Vasilios , Kontsiotis Vasileios J. 
Published: October 2020

AbstractBackgroundSmall coastal wetlands are vital sites for wintering waterbirds. Identifying important habitats is critical for managing waterbirds effectively. The Vourkari inlet is a small coastal wetland located near the capital Athens, within the most urbanized and industrialized area of Greece. We aimed at identifying the most important habitats for waterbirds at the Vourkari inlet during winter.MethodsData about habitat use and availability were collected for 14 waterbird species and for seven habitat classes. Habitat selection (Manly’s selection ratio), overlap indices (Pianka’s niche overlap index) and null models were calculated.ResultsAll the studied waterbird species selected available habitats nonrandomly. Shallow waters (0–2 m), were used by 13 waterbirds and selected by five waterbirds. Pools and channels were used and selected by 10 species. Mud was used by nine species and selected by six species. Mud with rocky substrate was used by nine species and selected by eight species. Medium (2–4 m) and deep (4–6 m) open water habitats were used by seven species and selected by four species. Halophytic vegetation was used by six species and selected by two species. Several habitats were selected by nationally important populations: mudflat habitats (i.e., mud, mud with rocky substrate and pools and channels) by Common Redshanks (Tringa totanus), halophytic vegetation by Little Egrets (Egretta garzetta), shallow waters by Common Shelducks (Tadorna tadorna) and medium and deep waters by Sandwich Terns (Thalasseus sandvicencis), whilst shallow waters and mudflat habitats were preferred by a possibly internationally important population of Mediterranean Gulls (Ichthyaetus melanocephalus). Although overlap in habitat use between species was generally low, null models indicated habitat sharing and a lack of competition.ConclusionsWaterbirds coexisted in the absence of competition for habitats at Vourkari, where they mostly used and preferred shallow water and mudflats. Small coastal wetlands are numerous, both in Greece and worldwide, therefore our findings would be useful as a basis for comparisons, both temporal at the inlet and spatial with other sites, that would help assess the importance of habitats and improve management strategies to benefit waterbirds, especially in areas with similar Mediterranean-type habitats and climate.
The prevalence of peri-implant disease following immediate implant placement and loading: a cross-sectional analysis after 2 to 10 years
Authors: Parvini Puria , Obreja Karina , Becker Kathrin , Galarraga Maria Elisa , Schwarz Frank , Ramanauskaite Ausra 
Published: October 2020

AbstractBackgroundTo evaluate the prevalence of peri-implant disease after immediate implant placement and loading.Material and methodsThis cross-sectional analysis included a total of 47 patients with 64 implants exhibiting a mean loading time of 2 to 10 years (4.23 ± 1.7 years). The surgical and prosthetic procedures were standardized in all patients. Peri-implant health and disease was assessed based on the established case definitions.ResultsThe prevalence of peri-implant health, peri-implant mucositis, and peri-implantitis amounted to 38.3%, 57.5%, and 4.2% of the patients, respectively. Mucosal recession of 1 mm was present at 4 (6%) implants. No suppuration, pain, or implant failures were reported. Ordinal logistic regression revealed that reduced keratinized mucosa height was significantly associated with the diagnosis of peri-implant mucositis and peri-implantitis (OR = 0.514,P = 0.0125).ConclusionImmediate implant placement and loading was associated with high success rates at 2 to 10 years.
Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis
Authors: Razmjou Amir A. , Brook Jenny , Elashoff David , Kaeley Gurjit , Choi Soo , Kermani Tanaz , Ranganath Veena K. 
Published: October 2020

Abstract
Background
Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitinib response by MSUS/MBDA scores and assessed whether baseline MSUS/MBDA scores or their early changes predict later clinical response.

Methods
Twenty-five RA patients treated with tofacitinib were assessed at baseline, 2, 6 and 12-weeks. Power doppler (PDUS) and gray scale (GSUS) ultrasound scores, MBDA score, clinical disease activity index (CDAI), and disease activity score (DAS28) were obtained. Pearson correlations and multiple linear regression models were used to evaluate associations and identify predictors of response to therapy.

Results
MSUS, MBDA scores, CDAI, and DAS28 improved significantly over 12 weeks (p < 0.0001). Baseline MSUS and MBDA score correlated with each other, and with 12-week changes in CDAI/DAS28 (r = 0.45–0.62, p < 0.05), except for GSUS with DAS28. Two-week change in MSUS correlated significantly with 12-week changes in CDAI/DAS28 (r = 0.42–0.57, p < 0.05), except for early change in PDUS with 12-week change in CDAI. Regression analysis demonstrated significant independent associations between baseline PDUS/MBDA score and 6-week change in CDAI/DAS28, with adjustment for baseline CDAI/DAS28 (all p < 0.05); and between baseline MBDA scores and 12-week change in DAS28 (p = 0.03).

Conclusions
RA patients treated with tofacitinib for 12 weeks demonstrated improvement by clinical, imaging, and biomarker end-points. Baseline PDUS and MBDA score were predictive of CDAI and DAS28 responses. This is the first study to evaluate early measurements of MSUS and MBDA score as predictors of clinical response in RA patients treated with tofacitinib.

Trial registration
ClinicalTrials.gov NCT02321930 (registered 12/22/2014).
In a case of female-to-male sex reassignment, testosterone therapy switches on an underlying Brugada
Authors: Vivona Patrizia , Dagradi Federica , Ciulla Michele M. 
Published: October 2020

Abstract
Background
The Brugada syndrome, diagnosed by a typical electrocardiographic pattern, is a genetic condition characterised by an increased risk of potentially lethal ventricular arrhythmias and sudden cardiac death. Even if its pathophysiological mechanism is unknown, its prevalence in male suggested a possible hormonal involvement.

Case presentation
In this case involving a woman who underwent a female-to-male sex reassignment, we documented that testosterone administration was able to switch on and, when stopped, to switch off a latent pattern of Brugada.

Conclusions
Our observation strongly supports a possible involvement of testosterone in the ECG manifestation of Brugada syndrome even if the general low prevalence of the Brugada syndrome does not support to screen every female-to-male sex reassignment.
Optimizing open data to support one health: best practices to ensure interoperability of genomic data from bacterial pathogens
Authors: Timme Ruth E. , Wolfgang William J. , Balkey Maria , Venkata Sai Laxmi Gubbala , Randolph Robyn , Allard Marc , Strain Errol 
Published: October 2020

AbstractThe holistic approach of One Health, which sees human, animal, plant, and environmental health as a unit, rather than discrete parts, requires not only interdisciplinary cooperation, but standardized methods for communicating and archiving data, enabling participants to easily share what they have learned and allow others to build upon their findings. Ongoing work by NCBI and the GenomeTrakr project illustrates how open data platforms can help meet the needs of federal and state regulators, public health laboratories, departments of agriculture, and universities. Here we describe how microbial pathogen surveillance can be transformed by having an open access database along with Best Practices for contributors to follow. First, we describe the open pathogen surveillance framework, hosted on the NCBI platform. We cover the current community standards for WGS quality, provide an SOP for assessing your own sequence quality and recommend QC thresholds for all submitters to follow. We then provide an overview of NCBI data submission along with step by step details. And finally, we provide curation guidance and an SOP for keeping your public data current within the database. These Best Practices can be models for other open data projects, thereby advancing the One Health goals of Findable, Accessible, Interoperable and Re-usable (FAIR) data.
Creative Arts Therapies and the LGBTQ Community: Theory and Practice, Brianna MacWilliam, Brian Harris, Dana Trottier and Kristin Long (eds) (2019)
Authors: Sayre Dana 
Published: October 2020

Review of: Creative Arts Therapies and the LGBTQ Community: Theory and Practice, Brianna MacWilliam, Brian Harris, Dana Trottier and Kristin Long (eds) (2019)
Philadelphia, PA: Jessica Kingsley Publishers, 284 pp.,
ISBN 978-1-78592-796-6, p/bk, $34.95
Action Explorations: Using Psychodramatic Methods in Non-Therapeutic Settings, Adam Blatner (ed.) (2019)
Authors: Witherspoon Hollis 
Published: October 2020

Review of: Action Explorations: Using Psychodramatic Methods in Non-Therapeutic Settings, Adam Blatner (ed.) (2019)
Seattle, WA: Parallax Productions, 366 pp.,
ISBN 978-1-73355-200-4, p/bk, $21.95
Dramatherapy for Borderline Personality Disorder: Empowering and Nurturing People through Creativity, Nicky Morris (2018)
Authors: Sherlock Belinda 
Published: October 2020

Review of: Dramatherapy for Borderline Personality Disorder: Empowering and Nurturing People through Creativity, Nicky Morris (2018)
Oxford and New York: Routledge, 162 pp.,
ISBN 978-1-13828-591-0, p/bk, £27.99