bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Sex Differences in Tumor-Specific T Cell Infiltration in Bladder Tumor-Bearing Mice Treated with BCG Immunotherapy
Authors: Rousseau Matthieu , O’Brien Conan J.O. , Antequera Eduardo , Zdimerova Hana , Cansever Dilay , Canton Tracy , Zychlinsky Scharff Anna , Ingersoll Molly A. 
Published: October 2020

BACKGROUND: Bladder cancer is the fourth most common cancer for men. However, women are often diagnosed with later stage disease and have poorer outcomes. Whether immune-based sex differences contribute to this discrepancy is unclear. In addition, models to investigate tumor-specific immunity in bladder cancer, in the context of tumor development or response to therapy, are lacking. OBJECTIVE: To address this specific unmet need, we incorporated a commonly used model antigen, ovalbumin, into two well-established models of bladder cancer; the orthotopic MB49 cell line model and the carcinogenic BBN bladder cancer model. METHOD: We tested the utility of these models to investigate tumor-specific immunity in the context of immunotherapy in both sexes. RESULTS: We found that BCG vaccination, prior to weekly BCG instillation does not impart an immune-specific benefit to tumor-bearing mice in the context of multiple BCG instillations. Furthermore, tumors developed in the testes in male mice, precluding the use of the MB49 model to directly investigate sex-based immune differences. In the BBN model, we observed that more tumor antigen-specific CD8+ T cells infiltrated male bladders compared to female bladders in the context of BCG immunotherapy whereas regulatory T cells had higher levels of the exhaustion marker PD-1 in female mice. CONCLUSIONS: We propose our modified BBN model will contribute to our understanding of how tumor-specific immunity arises in bladder cancer. Additionally, the BBN bladder cancer model may help to uncover sex differences in tumor-specific immunity, which would provide valuable information for the development of new treatments or combination therapies for bladder cancer in women and men.
Features of interrogation of minors who are victims of violence
Authors: Мілорадова Н. Е. , Пашко Н. О. 
Published: October 2020

The main provisions on the organization and conduction of interrogation of minors who are victims of violence have been revealed. The concept of physical, sexual and psychological violence against a child has been studied. The features of interrogation of minors who are victims of violence and their significance in criminal proceedings have been theoretically analyzed. The author has determined the subject matter, object and tasks of interrogation of minors and features of the impact of violence on the development of a child and evidence provided by this child.
Despite the large number of works focused on the study of various aspects of minors participation in different investigative actions, the legal and psychological literature does not sufficiently describe the psychological features of the interrogation of minors and does not fully analyze the factors that may affect the juvenile’s testimony while conducting such an investigative action as the interrogation.
The author has emphasized the expediency of conducting investigative (search) actions against children, based on the principles of child-friendly justice (participation of the child, ensuring the best interests of the child, dignity, protection against discrimination, rule of law).
The author has analyzed the algorithm of interrogation of a child based on the use of the following formula: “safe place + safe adult = safe child”; has provided recommendations to take into account the psychological and organizational features of different phases of the child’s interviewing; formulation of questions for minors who are victims of violence according to age and their psycho-emotional state. Examples of formulating the questions during the interviewing of children of preschool, primary school and adolescence age have been provided.
It has been noted that consideration of the described psychological features during the interrogation (interviewing) of children who are victims of violence, will reduce the protective mechanisms of the psyche, minimize re-traumatization of the child and increase the effectiveness of the interrogation.
Legal principles of counteraction to corruption and organized crime and the place of administrative and legal regulation among them
Authors: Вороний О. О. 
Published: October 2020

Based on the analysis of the current domestic and international legislation, the author has provided characteristics of the legal principles for combating corruption and organized crime.
It has been established that the legal principles for combating corruption and organized crime covers currently a large number of regulatory acts of international and national importance; it has been emphasized that a key place among them belongs to administrative and legal regulation.
It has been found out that administrative and legal regulation is a form of legal influence on public relations, which is carried out on the basis of the norms of administrative branch of law. Thus, this legal influence operates in the field of public relations that arise as a result of the activities of public law entities, in particular public authorities. Besides, administrative and legal regulation is, first of all, the system of norms that regulate organizational and administrative issues, aspects of the division of competence of public law entities and their legal relationship.
The emphasis has been placed on the fact that if we consider the system of legal principles for combating corruption and organized crime, they mostly consist of the rules of administrative law, since they regulate organizational forms of combating corruption and organized crime as a special activity of public authorities, determine the competence of each of the subject of combating corruption and organized crime, establish structural and system aspects of such activities, establish features of control and supervision over the process of its implementation, etc. It has been established that administrative and legal regulation is dominant in the system of legal principles for conducting activities to combat corruption and organized crime in Ukraine.
The genesis of forensic research of documents as the branch of forensic technology
Authors: Сезонов В. С. 
Published: October 2020

The history of the falsification of various documents for illegal purposes accompanies the entire history of human civilization, so the study of the evolution of methods of documenting information and related methods of forgery is one of the methods of improving forensic knowledge. The examination of documents similarly has a long history and is directly related to the emergence and spread of writing.
At the present stage of development of forensic document research, the achievements of various sciences are actively used to reveal the patterns in the field of forensic technology and its improvement. In particular, the study of the anatomical characteristics of writing and motor skills during the analysis of certain elements of handwriting; physiological processes that form the basis of movement control and reproduce written features or their combinations. The coordination of movements in the distribution of manuscripts according to the pace of writing is separately studied. Factors influencing the formation of written speech are determined by conducting experiments. Internal and external factors are taken into account, which allow to reconstruct the psycho-physiological features of the person who wrote the document, without which the establishment of its authorship is extremely problematic. Data of physiology and psychology help in the process of substantiating the stability of handwriting elements, drawing parallels between psycho-physiological characteristics of a person and certain graphic features.
Considering the acquired historical experience, modern forensic research can be divided into three categories: 1) handwriting, where the main purpose is to establish the executor of the document; 2) auto-research – finding out the authorship of the text of the document; 3) technical and forensic, which allow to accurately establish the remaining components of the document.
Forensic examination of documents has passed a long way in historical evolution. In its modern form, it was developed in the second half of the XX century due to a combination of theoretical principles and special methods borrowed from the natural and technical sciences. It allowed to determine as accurately as possible the technical features of producing a document or its part thereof, identifying the used tools and materials.
Economic, social and cultural human rights in the context of preventing the spread of COVID-19 in Ukraine
Authors: Зозуля О. І. 
Published: October 2020

Anti-epidemic measures introduced in Ukraine to prevent the spread of COVID-19 include significant (though often implicit) restrictions on the implementation of economic, social and cultural human rights, where the issues of reasonableness and legitimacy require particular attention, when the state of emergency in Ukraine is not announced. Dialectical, formal and legal, comparative and legal, system and structural, logical and semantic and other methods of scientific cognition have been used to solve the set tasks. Theoretical provisions and legal principles of introducing and realizing guarantees and restrictions of economic, social and cultural human rights (rights to health care, safe working conditions, business activity, equal access to public service, education, sufficient standard of living, social protection, etc.) have been analyzed. in terms of preventing the spread of COVID-19 in Ukraine. The nature and features of the established anti-epidemic measures have been characterized.
It has been determined that the lawful introduction of a number of reasonable and proportional restrictions on the implementation of economic, social and cultural human rights within the framework of preventive and anti-epidemic measures to prevent the spread of COVID-19 in Ukraine is justified in general by the interests of effective protection against this infectious disease. It has been established that some of the significant restrictions on the implementation of these human rights in connection with the COVID-19 pandemic in Ukraine are unsystematic and have contradictory legal nature, are insufficiently justified and proportionate to anti-epidemic goals, demonstrate the features of discrimination, are insufficiently specified in content and implementation procedure, as well as are not provided with additional guarantees for the realization of these human rights.
The author has grounded the ways for improving the guarantees and restrictions on the implementation of economic, social and cultural human rights in terms of preventing the spread of COVID-19 in Ukraine, which primarily require a comprehensive regulation of the relevant law and timely updating of their content and the implementation procedure, orientation of anti-epidemic measures not on restricting human rights, but on establishing special conditions of their realization with observance of the strengthened sanitary rules; ensuring the balance of the minimum necessary restrictions on human rights among themselves and with sufficient guarantees for their implementation.
Pengaruh Iklim Organisasi Terhadap Perilaku Produktif Karyawan Pada Bagian Sumber Daya Manusia Di Perusahaan Daerah Kebersihan Kota Bandung
Authors: Nur Azizah  , Gunadi Trida 
Published: October 2020

High and low of productive behavior of an employee really determines their work productivity, therefore it is necessary to foster the productive behavior. One way to foster productive behavior can be done with a conducive organizational climate. This study aims to determine how much influence the organizational climate on the productive behavior of employees in the Human Resources Section in the Regional Cleaning Company Bandung. The research method used is descriptive explanatory survey method. The data analysis technique used is a simple linear regression test and a significance test with the coefficient F. The results of the data analysis showed that the organizational climate on the Productive Behavior of employees was 32.442%. alternative hypothesis which states that there is a positive influence between organizational climate and employee productive behavior. The organizational climate and the productive behavior of employees as a whole are optimal, because the total scores obtained are both in the high category, but there are still things that must be considered, including management must be able to increase the empowerment of its employees so that the behavior and work performance of employees becomes more optimal.
MSC virtual e-abstract (CPP-03)
Authors: Stroke Conference 2020 Malaysia 
Published: October 2020

Activation of stroke protocol and thrombolysis in non ct hospital.
Outcome of stroke thrombolysis in lacunar stroke at HSNZ.
The use of international classification of functioning, disability and health (icf) to identify.
Cerebral venous sinus thrombosis: Clinical features and rehabilitation outcome.
Unlocking the locked-in syndrome (lis)’: International classification of functioning, disability and health (icf) as a clinical tool in formulating rehabilitation plans and overcoming challenges in lis patients.
Vestibular migraine : A case report.
Burden of stroke in Hospital USM, Kota Bharu, Malaysia.
Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling
Authors: Wang Yangyi , Petrikova Emilia , Gross Wolfgang , Sticht Carsten , Gretz Norbert , Herr Ingrid , Karakhanova Svetlana 
Published: October 2020

IntroductionThe broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity is poorly understood. We investigated the immunoregulatory effect of sulforaphane on human dendritic cells alone and in presence of pancreatic tumor antigens, as well as underlying molecular mechanisms.MethodsSulforaphane-treated human dendritic cells were matured in vitro with a cytokine cocktail, and the expression of regulatory molecules was examined by flow cytometry. The subsequent T-cell response was analyzed by T-cell proliferation assay and CD25 expression. To confirm the findings, dendritic cells pulsed with pancreatic cancer-derived tumor antigens were used. To identify the involved pathway- and microRNA-signaling in sulforaphane-treated dendritic cells, inhibitors of various signaling pathways, western blot analysis, microRNA array, and bioinformatic analysis were applied.ResultsSulforaphane modulated the expression of the costimulatory CD80, CD83 and the suppressive B7-H1 molecules on dendritic cells and thereby promoted activation of T cells. The effect was verified in presence of pancreatic tumor antigens. Phosphorylation of STAT3 in dendritic cells was diminished by sulforaphane, and the inhibition of JAK/STAT3 led to downregulation of B7-H1 expression. Among the identified top 100 significant microRNA candidates, the inhibition of miR-155-5p, important for the expression of costimulatory molecules, and the induction of miR-194-5p, targeting the B7-H1 gene, were induced by sulforaphane.ConclusionOur findings demonstrate that sulforaphane promotes T-cell activation by dendritic cells through the modulation of regulatory molecules, JAK/STAT3- and microRNA-signaling in healthy conditions and in context of pancreatic cancer-derived antigens. They explore the immunoregulatory properties of sulforaphane and justify further research on nutritional strategies in the co-treatment of cancer.
Filosofía y Derecho: Una experiencia académica en la Universidad de Ibagué
Authors: Barrero Arbeláez Juan Manuel 
Published: October 2020

El artículo presenta una reflexión del porqué resulta importante incluir en el plan de estudios del pregrado en derecho temas de filosofía política, ética, lógica y retórica, que son por tradición de interés de la filosofía. Además, se expone cómo puede aportar a un programa de derecho una relación académica continua con un programa o área de filosofía, todo esto a partir de la experiencia vivida en la Universidad de Ibagué.
KEPUASAN WISATAWAN DALAM PENGGUNAAN E-COMMERCE AGODA DALAM PEMESANAN HOTEL
Authors: Wachyuni Suci Sandi , Wiweka Kadek 
Published: October 2020

The industrial revolution that entered the 4.0 phase encouraged the industry to innovate, where one of the developing industries was e-commerce. As part of the OTA (tourism industry), e-commerce, or especially Agoda offers not only products but also services. However, at the moment, Agoda can be said to be left behind if we look at the ranking of the top brand awards, 2019. Therefore this research intends to examine the satisfaction of tourists (consumers) in using Agoda for booking a hotel. The approach used in this research is descriptive quantitative, where primary data is collected through a questionnaire with indicators of customer satisfaction (Repurchase, Word of Mouth, Brand Image, Product Quality, Price, Service Quality, and Emotional Factor). The scale used is Likert (1-5), and the sampling technique used is probability sampling, which is simple random sampling with a total of 100 respondents. The secondary data is taken from Agoda's website, books, literature, and previous research. The study was conducted during June-July 2019. This study found that the average tourist was quite satisfied - satisfied with Agoda's services in booking hotels. However, to maintain its existence, Agoda needs to make efforts to attract tourists, especially in improving the Agoda brand image. Also, the cooperation partners, which are hotels, will have high confidence in marketing their hotels through Agoda. Furthermore, in terms of the marketing segment, Agoda is very firmly attached to the millennial generation in meeting accommodation needs. However, it is interesting to investigate further the purpose of booking this accommodation, whether for travel needs or other vacation concepts, like one of the popular concepts nowadays, "staycation". This research is expected to provide information about service conditions and customer satisfaction using Agoda. So the results of this study can be useful not only for Agoda companies but also for other OTAs who offer similar products or services.

Keywords: kepuasan wisatawan, e-commerce, pemesanan hotel, online travel agent (OTA)
THE IMPACT OF AGROTOURISM DEVELOPMENT ON THE SOCIAL ECONOMIC LIFE OF LOCAL COMMUNITY KAMPUNG FLORY SLEMAN, YOGYAKARTA
Authors: Roels Ni Made Sri Puspa Dewi 
Published: October 2020

Penelitian ini dilakukan di Kampung Flory Desa Tridadi Sleman Yogyakarta. Kampung Flory memiliki tiga destinasi utama yang dibagi menjadi tiga zonasi yaitu Zona Taruna Tani, Bali Ndeso dan Desa Wisata Flory. Kampung Flory sudah dikembangkan enam tahun terakhir dan terus mengalami perkembangan yang cukup pesat. Fokus penelitian ini tentang dampak pengembangan agrowisata terhadap ekonomi masyarakat lokal. Agrowisata merupakan Zona Taruna Tani yang dikelola masyarakat lokal. Penelitian menggunakan pendekatan penelitian deskriptif kualitatif dengan pengumpulan data menggunakan in-depth interview, observasi dan dokumentasi. Metode analisis data yang digunakan menggunakan model interaktif yaitu: pengumpulan data, redukasi data, penyajian data dan penarikan kesimpulan. Hasil dari penelitian ini adalah masyarakat lokal mendapatkan dampak yang positif dari pengembangan agrowisata. Agrowisata Kampung Flory dikelola oleh generasi muda yang memiliki keterampilan dalam bertani. Para pemuda yang awalnya tidak tahu harus memasarkan produk tani kemana dan seperti apa, menjadi memiliki wadah untuk saling berbagi ilmu dan juga mendapatkan penghasilan. Tanaman yang dikembangkan ini kemudian dijual kepada para pecinta tanaman dan juga mendapat pemasukan dari wisatawan yang berkunjung. Masyarakat tidak hanya mendapat manfaat sebagai tenaga professional di Agrowisata Kampung Flory namun juga sebagai banyak yang bisa membuka usaha warung disekitar kawasan agrowisata. Produk yang dijual berupa makanan dan minuman khas Kabupaten Sleman. Pengembangan Agrowisata ini juga memberikan manfaat pengetahuan berupa keterampilan untuk bercocok tanam sehingga dapat menambah perekonomian masyarakat. Agrowisata hadir sebagai tempat masyarakat untuk menyalurkan hobi bertani dan juga dapat memberikan edukasi kepada wisatawan.
Fabrication of ultra-flat c-axis oriented ZnO thin films on atomically stepped cyclo-olefin polymer (COP) substrates by pulsed laser deposition at RT
Authors: Oga Tomoaki , Yamada Shiori , Kaneko Naho , Kaneko Satoru , Matsuda Akifumi , Yoshimoto Mamoru 
Published: October 2020

Abstract
Highly crystalline c-axis oriented ZnO thin films with ultra-flat surfaces were fabricated by pulsed laser deposition at RT on 0.3 nm high atomically stepped cyclo-olefin polymer (COP) substrates whose surfaces were thermally nanoimprinted using atomically stepped sapphire molds. X-ray diffraction and atomic force microscopy measurements showed that the atomically-controlled surfaces of COP substrates enhanced the c-axis orientation and surface flatness of the crystalline ZnO thin films. The ZnO thin films grown on the atomically stepped COP substrates exhibited atomically stepped surface morphology, and also the optical bandgap of about 3.3 eV and RT resistivity of 5.0 × 10−2 Ω cm.
APLIKASI PEMBELAJARAN SISWA SEKOLAH DASAR MENGGUNAKAN METODE MULTIMEDIA DEVELOPMENT LIFE CYCLE (MDLC)
Authors: Sumaryana Yusuf , Hikmatyar Missi 
Published: October 2020

Model pembelajaran menggunakan teknologi Komputer sudah selayaknya dikembangkan di era sekarang ini. Komputer sebagai salah satu bagian teknologi saat ini semakin berkembang fungsi nya. Para siswa dapat dengan mudah mengoperasikan dan melakukan kegiatan belajar menggunakan teknologi komputer. Salah satu fasilitas yang bisa digunakan adalah teknologi komputer multimedia dimana para siswa bisa menggunakan perangkat lunak pembelajaran multimedia interaktif. Multimedia digunakan sebagai sarana pembelajaran yang diharapkan dapat meningkatkan minat belajar siswa, karena terdiri dari unsur audio visual. Multimedia Development Life Cycle (MDLC) merupakan metode yang digunakan pada penelitian ini untuk pengembangan perangkat lunak berbasis multimedia. Dimana ada 6 (enam) tahapan yang harus dilakukan dalam proses pelaksanaannya. Adobe CS digunakan untuk membuat aplikasi multimedia yang telah dirancang.
A retrospective examination of the effects of regional anesthesia methods applied for postoperative pain control on analgesic consumption after lower extremity surgery
Authors: Erol Mehmet Kenan 
Published: October 2020

Objective: If preferable, the regional anesthesia is a more preferred method than general anesthesia. The preference for regional anesthesia increases as postoperative recovery is quicker, hospitalization is less and hospital costs are low.
Material and methods: We retrospectively evaluated the hemodynamic findings, postoperative pain, hospital, and intensive care stay in patients aged 18-80 who underwent lower extremity surgery with regional anesthesia in the last 1 year. We divided the cases into 3 groups; Group 1 (n =114) patients with a peripheral nerve block, Group 2 (n =104) spinal anesthesia, and Group 3 (n =81) epidural anesthesia.
Results: The difference between group 1 and 2, age hospitalization, and time of stay in intensive care was statistically significant. (P=0.021) (P=0.000). The difference between group 1 and 3 Intensive care unit stay was statistically significant (P = 0.003). The difference between the length of stay in the intensive care unit between groups 2 and 3 was found as statistically significant (P = 0.000). There was no significant difference in terms of hospital stay. Group 1 was found to have the shortest duration of intensive care stay.
Conclusion: In lower extremity surgeries, peripheral nerve blocks may have provided more hemodynamic stability and longer analgesic effect compared to central blocks.