bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of percutaneous coronary intervention using bioresorbable vascular scaffold and minimally invasive direct coronary artery bypass for left anterior descending artery disease: 3-year clinical outcomes
Authors: Vakkosov K. M. , Ganjukov V. I. 
Published: January 2020

Aim. Evaluates 3-year clinical outcomes of percutaneous coronary intervention (PCI) with bioresorbable vascular scaffold (BVS) versus minimally invasive direct coronary artery bypass (MIDCAB) surgery for the treatment of left anterior descending (LAD) lesions.Methods. In this single-center study were included 130 patients with stable angina and significant (≥70%) LAD disease. Patients were randomly assigned in a 1:1 ratio to PCI with everolimus-eluting bioresorbable vascular scaffold (Absorb) (n = 65) or MIDCAB (n = 65). The primary end-point was major adverse cerebrocardiovascular events (MACCE) and secondary was. Primary and secondary endpoints were, respectively, major adverse cerebro-cardiovascular events (MACCE) and target vessel failure at 3-year.Results.The groups of patients were comparable for all baseline demographic, clinical and angiographic parameters. The primary composite endpoint of MACCE through 3 years occurred in 16.9% of BVS patients and 9.2% of MIDCAB patients (p = 0.19). But 3-year any revascularization rates were higher with BVS (13.8% vs. 3.1%; p = 0.027). TVF was favor of the MIDCAB group (12,3% vs. 3,1%, p = 0.04), mainly triggered by high subsequent need for revascularization of the targeted vessel in the BVS group (9.2% vs. 1.5%; p = 0.05).Conclusion. At 3-year follow-up, PCI by BVS and MIDCAB in in patients with isolated LAD lesions yielded similar long-term outcomes regarding the primary composite clinical endpoint. The bioresorbable scaffold was associated with a higher incidence of reinterventions, TVF and TVR than the MIDCAB through 3 years of follow-up.
Impact of pulmonary vein anatomy on cryoballoon isolation results
Authors: Chichkova T. Yu. , Mamchur S. E. , Khomenko E. A. , Romanova M. P. , Kokov A. N. 
Published: January 2020

Aim. To estimate the efficacy of pulmonary veins (PV) cryoballoon isolation in its different anatomical variants.Methods. 230 patients 57 (53; 62) years of age were enrolled in the study in approximately equal proportion of males and females. Up to 1/3 of patients suffered from isolated AF, most of them belonged to the category of high risk of thromboembolic complications. To evaluate the PV anatomical variant, a modified classification of E. Marom et al was used. In groups of cryoballoon and radio-frequency isolation, subgroups of typical and variant anatomy were distinguished. Evaluation of the effectiveness of the intervention was based on the identification of any (symptomatic and asymptomatic) documented episodes of atrial arrhythmias lasting more than 30 seconds during the observation period of 12 months.Results. Comparison of efficacy in typical PV anatomy did not reveal significant differences between cryo and RFA groups, regardless of the type of device used. Subgroup I of generation of cryoballoons showed freedom from AF 83.2%, II generation – 87.5%, RFA group – 82.7% at p = 0.82. At the same time, with PV variant anatomy, the efficiency of cryo isolation with the use of II generation devices was 52.2 versus 85.7% in the RFA group (OR = 0.25; 95% CI 0.09–0.71; p = 0, 02). When analyzing long-term results in cryo and RFA groups depending on the anatomical variant, it was found that with RFA, the presence of a left PV common trunk (collector / vestibule), as well as the presence of additional veins, showed results comparable with the group of typical anatomy. At the same time, in the cryoablation group, the presence of a left common trunk was accompanied by a decrease in efficiency to 23.1 versus 84.9% for typical anatomy (OR = 0.14; 95% CI 0.03–0.6; p = 0.02) and 90% in the presence of additional veins (OR = 0.1; 95% CI 0.01–0.64; p = 0.02). In the presence of a left common trunk, the efficiency of cryoablation using second-generation cylinders was 23.1 versus 82.4% in the RFA group (OR = 0.16; 95% CI 0.05–0.5).Conclusion. The presence of a left PV common trunk leads to a decrease in the effectiveness of cryoablation in the long-term observation period relative to the group of typical anatomy to 23.1 versus 84.9% (OR = 0.14; 95% CI 0.03–0.6) and 82.4% for radiofrequency ablation (OR = 0.16; 95% CI 0.05–0.5). The presence of additional veins of right-sided localization does not affect the effectiveness of the intervention.
The Application of Clay Pot for Moisture Reduction of Geniotrigona thoracica Stingless Bee Honey
Authors: Mohamad Ghazali Nashratul Shera , Yusof Yus Aniza , Nyuk Ling Chin , Othman Siti Hajar , Abdul Manaf Yanty Noorzianna , Mohd Baroyi Syahrul Anis Hazwani 
Published: January 2020

Geniotrigona thoracica (G. thoracica) stingless bee honey contained high moisture that can easily lead to fermentation process. The high moisture content of stingless bee honey could lead to unwanted fermentation and crystallization form. Hence, it will affect the quality of honey in terms of acidic taste and undesirable appearance. To make sure stingless bee honey meets the standard set by IHC, some methods have been carried out to reduce its moisture content. This study investigates the moisture reduction during storage of G. thoracica stingless bee honey in a clay pot. The G. thoracica honeys were stored in clay pot with the inner volume of 75.4cm3 and glass bottle (as control) at 25ËšC for 21 days. Physicochemical analysis of honey such as moisture content, total soluble solid, water activity, viscosity, pH, free acidity, electrical conductivity, colour (L*, a* and b*) and colour intensity were investigated during storage. The result obtained indicated that the honey stored in a clay pot was significantly reduced the moisture content from 28.03% to 16.51%. The water activity (aw) of honey in a clay pot was also reduced from 0.779 to 0.601. The free acidity of honey stored in a glass bottle increased significantly compared to honey stored in a clay pot, which was initially 106.7meq/kg to 146.3meq/kg and 121.7meq/kg, respectively. In conclusion, the application of clay pot as a storage medium was capable to reduce water content and preserved the quality of honey from G. thoracica.
Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Activity of Ultrafiltration and Gel Filtration Fraction of Gelatin Hydrolyaste Derived from Bone of Fish for Antidiabetes
Authors: Atma Yoni , Lioe Hanifah Nuryani , Prangdimurti Endang , Seftiono Hermawan , Taufik Moh. , Mustopa Apon Zaenal 
Published: January 2020

Bioactive peptides have been investigated largely for many biofunctional properties. The aim of this research was to determine the inhibitory activity of ultrafiltration (UF) and gel filtration (GF) fractions of gelatin derived from bone of Pangasius catfish against dipeptidyl peptidase IV (DPP-IV). Previous studies have shown that gelatin from skins of salmon, hake, halibut, milkfish, tilapia and bone of pangasius catfish have the activity in DPP-IV inhibition. While, as inhibitor, most of previous and recent studies shown that separation and fractination of gelatin hydrolysate increase their activity. This research was conducted in three stages including gelatin hydrolysates fractination by ultrafiltration (UF), UF fraction loaded into gel filtration (GF) and DPP-IV inhibition measurement. The fish bone gelatin was hydrolyzed using flavourzyme at three enzyme/substrate ratios (E/S of 3%, 6% and 9%) with incubation times 4, 6, and 8 h. Then, the hydrolysates fractioned by ultrafiltration with 3 kDa cutoff membrane continued with Superfine G-25 sephadex column (65 cm x 3 cm, flow rate 1 mL/min). The result shown that both group of fractions i.e UF and GF have inhibitory activity regarding their capacity to inhibit DPP-IV. The UF fraction >3 kDa derived from 9% (E/S) ratio for hdyrolysis were superb as DPP-IV inhibitor than other fractions, the highest one also has bioactivity higher than other previous fish gelatin fractions.
Petrological Characteristic and Whole Rock Geochemistry of Metamorphic Rocks in Melangè Complex of Ciletuh Area, West Java, Indonesia
Authors: Ikhram Rinaldi , Syafri Ildrem , Rosana Mega Fatimah 
Published: January 2020

Melangí¨ Complex of Ciletuh Area, West Java, Indonesia is located at 106 ° 23 '38.9 "- 106 ° 25' 27.6" E and 7 ° 14 '27.6 "- 7 ° 12' 46.2" S. This area has unique geological features where the Early Cenozoic uplifted subduction rocks such as ophiolites and metamorphic rocks are exposed. This study aimed to determine the condition of the stratigraphic position and geological structure of metamorphic rock unit in the field, to find out the metamorphic facies and their evolution, to know the parental rocks (protoliths) of metamorphic rocks, and to interpret tectonic environments for the formation of metamorphic rocks based on stratigraphy, geological structure, petrography, and geochemistry. Study of literatures, geological mapping, petrology and geochemical analyses were used as methods of this research. The entire analysis is combined as a guidance in interpretation of petro-tectonic environment. Distribution of metamorphic rock outcrops found in several places, such as, Citisuk River, Cikopo River and Cikarikil River. Based on petrography analysis, metamorphic rocks types consist of schistose amphibolite, various type of greenschist, phyllite and quartzite. The protolith of metamorphic rocks in Ciletuh is quite diverse, namely metasediments such as pelitic, psammitic, calc-silicate sediment, and meta-igneous such as gabbro and basalt. The presence of epidote, chlorite, and calcite in schistose amphibolite show retrograde metamorphism process in lower temperature-pressures condition. The occurance of quartz and calcite vein in several samples was shown as an indication of hydrothermal alteration. Based on geochemical characteristics, the result showed that sedimentary source of metasedimentary rocks were derived from the volcanic arc environment. While, metabasalt rocks were originated from the Island Arc tectonic environment. According to the association, these metamorphic rocks were formed by regional metamorphism, as the result of subduction process and orogenic event. Thus, retrograde metamorphism indicates the lifting or accretion process that caused by subsecuent tectonic activity.
Measuring the Substitution of Vegetable Waste Fermented Rumen Fluid with Tofu Waste in Vannamei Shrimp Feed
Authors: Murni - , Haryati - , Sonjaya Herry , Aslamyah Siti 
Published: January 2020

Vannamei shrimp cultivation in Indonesia deals with the complication at high feed fees as a result of raw material feed protein sources. Rumen fluid fermented vegetable waste has the potential to substitute tofu in feed Litopenaues vannamei. This study aims to determine the substitution of vegetable waste with the rumen fluid fermented tofu is best to improve the performance of vannamei shrimp growth. Research carried out for 60 days with evaluation substitution levels of rumen fluid fermented vegetable waste with tofu in vannamei shrimp feed. designed using a completely randomized design (CRD) with 4 treatments each with 3 replications, thus totaling 12 experimental units. Feed treatment tested is A) 0 (control), B) 33.33, C) 66.67, D) 100% rumen fluid fermented vegetable waste. The results showed that the substitution of tofu with fermented vegetable waste rumen fluid in vannamei shrimp feed a significant effect (P <0.05) on digestive enzyme activity, total and nutrient digestibility, growth, and survival rate of vannamei shrimp. The research shows that the tofu substitution more than sixty percent of fermented vegetable waste could improve feed efficiency to more than a quarter of vannamei shrimp growth. Tofu substitution of rumen fluid fermented vegetable waste in feed could increase the activity of digestive enzymes, total digestibility, nutrient digestibility, growth, and survival of juvenile vannamei shrimp.
Notas sobre a trajetória do decrescimento: origens, concepções e proposições
Authors: Do Nascimento Elimar Pinheiro , Tasso João Paulo Faria 
Published: January 2020

Há quase meio século discute-se a finitude dos recursos naturais e a irracionalidade de sua exploração pelo modelo econômico vigente que resultou na presente crise ecológica. Este artigo discute o Decrescimento, uma das saídas propostas à esta crise. Nome propositalmente antipático para que o establishment não se aproprie, como ocorre com o Desenvolvimento Sustentável. O objetivo é desenhar a trajetória do Decrescimento para identificar as possibilidades e limites. Pesquisaram-se as principais publicações que sustentam a proposição. As origens do Decrescimento são múltiplas, tanto de caráter econômico como cultural e as proposições são variadas. Contudo, há três certezas: a ideologia do crescimento, que rege o presente modelo econômico, caso não seja modificado, nos levará a uma catástrofe; medidas paliativas, como as propugnadas pelo Desenvolvimento Sustentável, não conduzem a uma solução da crise ecológica; a saída possível é quebrar a lógica da ideologia do crescimento, buscando uma vida mais simples, com relações sociais mais agradáveis e melhor distribuição, e redução, dos bens materiais. O artigo finaliza perguntando-se sobre a possibilidade de as propostas do Decrescimento serem levadas a cabo, e quais os seus obstáculos.Palavras-chave: Desenvolvimento Sustentável. Decrescimento. Crise Ambiental.
Gül Yetiştiricilerinin Sosyo-ekonomik Nitelikleri ve Kullandıkları Bilgi Kaynakları: Isparta İli Örneği
Authors: ÇELİK ATEŞ Hacer , DOĞUTAŞ Ahmet Umut 
Published: January 2020

Amaç: Bu çalışmada gül
yetiştiricilerinin sosyo ekonomik özelliklerini belirleyerek , yetiştiricilerin
yararlandıkları bilgi kaynaklarını ortaya koymak amaçlanmıştır.

Materyal ve Metot: Isparta
İlinde en yüksek
üretim alanı ve yetiştirici sayısına sahip Keçiborlu, Gönen ve Merkez İlçeleri
araştırma bölgesi olarak ele alınmıştır. Örnek hacminin belirlenmesinde ise
basit tesadüfi örnekleme yöntemi kullanılmış ve
örnek hacmi 152 olarak bulunmuştur. Verilerin analizinde oransal dağılımlar, khi kare ve Multiple
Correspondence Analizleri (çoklu uyum analizleri) kullanılmıştır.

Bulgular : Gül
yetiştiricilerinin yaş ortalamalarının 45.7, büyük bir çoğunluğu erkek (%92.1),
eğitim seviyesi lise ve üniversitedir (%54.9). Hane halkı sayılarının
ortalaması 3.1’dir. Gül yetiştiricilerinin meslek dağılımında ilk sırayı çiftçi grubu (%32.9)
almaktadır. Bunu sırasıyla serbest meslek (%20.4), işçi (%19.7) ve memurlar (%14.5)
izlemektedir. Gül ile ilgili en işe yarar bilgiyi yetiştiricilerin %67.8’inin aile büyükleri,
akraba veya komşu üreticilerden, %20.4’ünün zira ilaç bayilerinden, %7.2’sinin
tarım il/ilçe müdürlüklerinden ve %4.6’sının özel danışmanından aldığı tespit
edilmiştir.MCA analizine göre gül yetiştirmeye devam edecek yetiştiriciler,
lise mezunu ve 31-45 yaş aralığındadır.

Sonuç: Araştırma sonucuna göre,
gül yetiştiricilerinin bir sorunla karşılaştıklarında ilk başvurdukları bilgi
kaynağı zirai ilaç bayileri olmaktadır. Ancak en yararlı bilgi kaynağı olarak
ilk sırada aile büyükleri/akraba/komşuyu, ikinci sırada zirai ilaç bayilerini, üçüncü
sırada ise Tarım il/ilçe müdürlüklerini görmektedir. Zirai ilaç bayilerinden edindikleri bilginin beklenen faydayı
göstermediği ve yetiştiricileri tatmin etmediği, ayrıca kamunun bilgi kaynağı
olarak gerilere düştüğü ortaya çıkmıştır.
Correlation between Serum IL-6 Level and Th17/Treg Ratio with Systemic Lupus Erythematosus Disease Activity
Authors: Familia Adidia Carina , Yuliasih Yuliasih , Rahmawati Lita Diah 
Published: January 2020

Introduction: SLE pathophysiology shifted to a new paradigm which emphasizing the imbalance between Th17 and Treg. IL-6 is the main cytokine believed as the regulator of the balance between Th17 and Treg which play a big part in SLE pathophysiology and disease activity. The aim of this study was to determining the correlation between serum IL-6 level and Th17/Treg ratio with SLE disease activity on SLE inpatients of RSUD Dr. Soetomo Surabaya.Methods: This cross sectional study included newly diagnosed SLE patients based on American College of Rheumatology (ACR) 1997 revised criteria and confirmed by rheumatologist. All subjects underwent the same examination and assessment such as SLE disease activity was scored according to SLAM score, serum IL-6 level measured using ELISA, and Th17/Treg ratio where the expression Th17-Treg detected by flowcytometry method.Results: Thirty female subjects with active SLE had mean age 31,3 ± 10,46 years. The most frequent clinical manifestations were hematologic disorders and arthritis. Serum IL-6 level was significantly elevated in SLE patients compare to healthy subjects (200,61 pg/ml versus 45,9 pg/ml, p =0,028). Th17/Treg ratio were also significantly higher in SLE patients compared to healthy subjects (2,49 versus 1,20, p = 0,31). Th17/Treg ratio significantly correlated with SLE disease activity (r = 0,988; p<0,05). There were no significant correlation between serum IL-6 level with Th17/Treg ratio (r = -0,095; p>0,05) or even SLE disease activity (r = 0,066 ; p>0,05). Conclusion: Serum IL-6 level had no significant correlation with Th17/Treg ratio or SLE disease activity. We found significant correlation between Th17/Treg ratio with SLE disease activity.
Features of obtaining the catalyst for the synthesis of carbon nanotubes
Authors: Burakova E. A. , Besperstova G. S. , Neverova M. A. , Tkachev A. G. , Orlova N. V. , Dyachkova T. P. 
Published: January 2020

In this paper, the features of obtaining a Co-Mo/Al2O3 catalyst to synthesize carbon nanotubes (CNTs) by thermal decomposition were studied. It was revealed that the duration of the pre-catalyst thermal decomposition stage in the process of developing a metal oxide system has a significant impact on its activity in the synthesis of carbon nanostructured materials by chemical vapor deposition (CVD). It was proved that an effective catalyst for CNTs synthesis can be obtained by through thermal decomposition of the pre – catalyst, without calcination of the metal oxide system. The use of the Co-Mo/Al2O3 catalyst, synthesized in such a way, in the CVD process makes it possible to reduce the cost of synthesized CNTs. Using scanning electron microscopy, it was shown that the size of the grains, and specific surface area of the formed Co-Mo/Al2O3 catalyst depend on the thermal treatment conditions of the pre-catalyst. Under the conditions for the implementation of the pre-catalyst thermal decomposition stage (temperature, volume, duration, etc.), it is possible to contro not only the characteristics of the resulting catalyst (specific surface area, efficiency), but also the characteristics of the CNTs (diameter, degree of defectiveness). In the course of experiments, the optimal modes of implementation of the method for obtaining the Co-Mo/Al2O3 catalyst allowed forming a system with a specific surface area of ~ 108 m2/g. The use of the resulting catalyst in the synthesis of nanostructured materials provides a high specific yield of multi-walled CNTs with a diameter of 8-20 nm and a degree of defectiveness of 0.97.
Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt
Authors: Romijn Lotte B , Almet Axel A , Tan Chin Wee , Osborne James 
Published: January 2020

Abstract
Background: Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how cell level properties can lead to mutant cell invasion, but has not incorporated detailed subcellular modelling
Results: We present a framework that allows the straightforward integration and simulation of SBML representations of subcellular dynamics within multiscale models of epithelial tissues. This allows us to investigate the effect of mutations in subcellular pathways on the migration of cells within the colorectal crypt. Using multiple models we find that mutations in APC, a key component in the Wnt signalling pathway, can bias neutral drift and can also cause downward invasion of mutant cells in the crypt.
Conclusions: Our framework allows us to investigate how subcellular mutations, i.e. knockouts and knockdowns, affect cell-level properties and the resultant migration of cells within epithelial tissues. In the context of the colorectal crypt, we see that mutations in APC can lead directly to mutant cell invasion.
Ultrasound-guided single erector spinae plane block versus thoracic paravertebral block for patients undergoing video-assisted thoracoscopic lobectomy: a single center randomized controlled trial
Authors: Ma Danxu , Ren Huilong , Li Xueyang , Li Huili , Jiang Jia , Wu Anshi , Wang Yun 
Published: January 2020

Abstract
Background: Whether ultrasound-guided erector spinae plane block (ESPB) can replace thoracic paravertebral block (TPVB) remains unknown. This study aimed to determine the efficacy of ESPB compared with TPVB for postoperative analgesia after video-assisted thoracoscopic lobectomy under general anesthesia. Methods: This prospective randomized controlled trial divided patients into a control group, a TPVB group (0.3 mL/kg, 0.5% ropivacaine), and an ESPB group (0.5 mL/kg, 0.5% ropivacaine). Dermatomes with loss of pinprick sensation, were recorded during 30 min after block administration. Visual analog scale (VAS) scores, total analgesic dose, and complications after surgery were recorded. Results: Whether at rest or during coughing, the VAS scores were lower in ESPB group at 1, 6, 18, 24, and 48 h after surgery compared with the Control group. VAS scores were similar in the ESPB and TPVB groups at 1 h, but were lower in the ESPB group at 6, 18, 24, and 48 h postoperatively. Conclusions: Single ESPB provided superior postoperative analgesia than TPVB, without causing any adverse effect.
Policymaking Challenges in the Oral Health in a Low-income Developing Country:A Qualitative Approach
Authors: Mohammadpour Mohammad , Bastani Peivand , Ghanbarzadegan Arash , Bahmaei Jamshid 
Published: January 2020

Abstract
Background: As the strategies proposed for oral health improvement in developed countries do not adapt for the setting of the developing ones, this study aimed to identify the challenges and barriers of oral health policymaking in Iran as a low-income developing country.
Methods: This is a qualitative study conducted in 2019 in Iran as a middle-eastern developing country. The study population consisted of all the experts who had enough experience in the oral health and were willing to participate in the study. Snowball sampling was used to select 12 participants for semi-structured interviews and saturation was achieved after 16 interviews with them. Guba and Lincoln criteria including credibility, transferability, confirmability and dependability were used to determine the reliability and transparency, and finally five-step framework analysis method was used to analyze the data.
Results: The analysis of the results of the interviews resulted in identification of 7 main themes and 20 sub-themes as the main challenges of achieving oral health in Iran as a developing country. The main themes identified were: policymaking, implementing, educational, stewardship, prevention, insurance, and resource allocating.
Conclusion: According to the present results, it seems that the national coverage of oral health and integration of these services in prevention and serious attention to the private sector can be considered as the most important strategies for achieving improved oral health.
Keywords: oral health, developing country, policymaking, strategy.