bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex dependent correlation of spleen atrophy and behavior deficits induced by binge treatment with ethanol in rodent models
Authors: Zhang Jonathan , Bishir Muhammed , Huang Wenfei , Chang Sulie L. 
Published: December 2024

Abstract

Objectives
During physical and psychosocial development, many adolescents engage in binge alcohol drinking. Ethanol (EtOH) is the key chemical in alcoholic beverages. EtOH intoxication impairs locomotor behaviors. We previously found that binge treatment with EtOH (BE) causes spleen atrophy, leading to immune dysregulation. With these premises, we hypothesized that BE-induced spleen atrophy is correlated with compromised locomotion and behaviors in adolescence.

Methods
We exposed F344 rats to either 3 days of BE (mimicking college drinking) or water following pubertal onset. 24 h following the last BE, we assessed behaviors using ANY-Maze, focusing on locomotor activity, freezing, and thigmotaxis, before spleen collection. Correlation analysis and Linear Regression analysis quantified BE’s effects on behavior. In parallel, we used GEO2R to obtain differentially expressed genes (DEGs) from public dataset GSE49028 (B6129Sf2/J mice were given BE) and identified signaling pathways in the prefrontal cortex (PFC) involved in BE compromising locomotion and increasing anxiety.

Results
BE significantly decreased spleen size. Interestingly, we found that BE exposure had a gender-dependent impact, affecting males more than females. Furthermore, functional analysis of the dataset identified several targets of interest including the downregulation of BDNF as a critical regulator of behavioral deficit following BE treatment.

Conclusions
Using data-driven discovery and hypothesis-testing investigation to integrate these two studies, we provide an understanding of the underlying biological mechanism of BE-induced spleen atrophy-associated behavioral impairments through the genetic alterations in the PFC. Our findings will help develop a potent, powerful cocktail of reagents to treat behavioral impairment in those who binge drink.
Glossary of terms for mass and volume in analytical chemistry (IUPAC Recommendations 2024)
Authors: Camões Maria F. , Christian Gary D. , Hibbert David Brynn 
Published: December 2024

Abstract
A glossary of terms and definitions for concepts in the use of mass and volume in analytical chemistry is presented. These include definitions for analytical methods of measurement (gravimetry, volumetry, and titrimetry) and supporting terms. Terms are updates of earlier recommendations or Orange Book entries.
Saúde mental de mulheres transgêneras: uma revisão integrativa de literatura / Mental health of transgender women: an integrative literature review
Authors: Cortes Helena Moraes , De Morais Andréia Vanessa Carneiro , Carnevalli Ligia Maffei , Pinho Paula Hayasi 
Published: December 2024

Objetivo: conhecer a produção científica nacional e internacional acerca da saúde mental das mulheres transgêneras de 2007 a 2017. Método: revisão integrativa realizada na Biblioteca Virtual em Saúde, em abril de 2018. Analisaram-se os estudos em seis fases, agrupando-os em categorias temáticas. Resultados: dos 30 estudos selecionados emergiram sete categorias temáticas, a saber: “necessidades de saúde mental”, “vulnerabilidade psicossocial”, “processo transexualizador”, “mulheres transgêneras jovens e na terceira idade”, “relações sociais”, “direitos civis e cidadania” e “relações entre as mulheres transgêneras e os serviços de saúde”. Conclusões: mulheres transgêneras estão expostas a maiores riscos de desenvolverem transtornos mentais, em relação às pessoas cisgêneras parecendo ter relação com o preconceito, estigma, discriminação, e negação de direitos civis. São transtornos mais prevalentes nesta população: depressão, ansiedade, ideação/ tentativa de suicídio, abuso de álcool e outras drogas, os quais estão diretamente relacionados com o não acesso aos serviços de saúde. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessada pelo seguinte endereço eletrônico: Saúde mental de mulheres transgêneras: uma revisão integrativa de literatura | Journal of Nursing and Health (ufpel.edu.br)
Barbearia Autogestionária: Experiência de Capacitação Profissional de Jovens em Cumprimento de Medidas Socioeducativas
Authors: Lussi Isabela Aparecida de Oliveira , Fugikaha Ana Cláudia Esteves dos Reis , Alves Ana Laura de Melo , Saad Claudia Daher , Felicio Thauana Leticia 
Published: December 2024

A parceria entre o movimento da Economia Solidária e o da Reforma Psiquiátrica possibilitou o desenvolvimento de experiências práticas e de aparato jurídico-político que promoveram o fomento de empreendimentos econômicos solidários constituídos por pessoas que se encontravam excluídas do mundo do trabalho por apresentarem problemática no campo da saúde mental. Neste cenário, a Economia Solidária incorporou o cooperativismo social destinado a pessoas em situação de desvantagem social, entre eles, jovens em cumprimento de medidas socioeducativas. Este estudo teve como objetivo descrever a metodologia desenvolvida no projeto de capacitação profissional em barbearia autogestionária, de jovens participantes do Programa de Medidas Socioeducativas na modalidade “Liberdade Assistida”, compreendida como tecnologia social. A capacitação foi desenvolvida em três eixos centrais: 1) Construção do Grupo; 2) Formação Técnico-Prática; 3) Inclusão em Grupos. Os resultados mostraram que os impactos da experiência foram bastante positivos na vida dos jovens participantes, tanto segundo eles, na perspectiva de construção de projetos de vida; como segundo seus familiares. Argumentamos que é na construção coletiva que sonhos se tornam realidade, transformam vidas e trilham caminhos menos danosos.Palavras-chave: economia solidária; autogestão; cooperativismo social; juventude; medidas socioeducativas; tecnologia social Abstract: The partnership between the Solidarity Economy and the Psychiatric Reform movement made possible the development of practical experiences and a juridical-political apparatus that promoted the development of solidarity-based economic enterprises constituted by people who were excluded from the working world because they presented problems in the field of mental health. In this scenario, Solidarity Economy incorporated social cooperativism aimed at socially disadvantage participants, including, the youth in compliance with socio-educational measures. This study aimed to describe the methodology developed in the project of professional training in a self-managed barbershop of young people participating in the program of Socio-educational Measures in the "Assisted Freedom." modality, understood as social technology. The training was developed in three central axes: 1) Construction of the Group; 2) Technical and Practical Training; 3) Inclusion in Groups. The results showed that the impacts of the experience were very positive in the lives of the young participants, according to them and their relatives, from the perspective of building life projects. We argue that it is in the collective construction that makes dreams come true, transforming lives and helping the youth choose less harmful paths.Keywords: solidarity economy; self-managed; social cooperativism; youth; educational measures; social technology
Mulheres e economia popular solidária na construção do bem-viver
Authors: Silva Carlúcia Maria 
Published: December 2024

O presente trabalho é fruto de ações extensionistas desenvolvidas por docentes e discentes da Universidade do Estado de Minas Gerais (UEMG Barbacena), em 2018 e 2019. As ações do referido Projeto tiveram como um de seus principais objetivos acompanhar, na Microrregião Barbacena, grupos de mulheres atuantes na prática do cooperativismo, da autogestão e da economia popular solidária. Metodologias de pesquisa-ação foram adotadas com o uso das seguintes estratégias: participação em reuniões, observação direta junto a empreendimentos de economia popular solidária, diário de campo objetivando o registro de informações e observação participante em eventos formativos, organizativos e celebrativos dos empreendimentos. A participação nas reuniões do Fórum Regional Vertentes de Economia Popular Solidária e do Fórum Estadual de Economia Solidária. Foram também espaços privilegiados de formação e organização. Os resultados apontam o protagonismo das mulheres e a economia popular solidária como ferramenta e instrumento de participação, cidadania; inclusão produtiva, em busca do Bem-viver.Palavras-chave: trabalho; mulheres; economia popular solidária; bem-viver. Abstract: The present work is the result of extension actions developed by professors and students of the State University of Minas Gerais (UEMG Barbacena), in 2018 and 2019. In its actions, the referred Project had, as one of its main objectives monitored, in the Barbacena Microregion, groups of active women in the practice of cooperativism, self-management and the popular solidarity economy. Action-research methodologies were adopted using the following guidelines: participation in meetings, direct observation with popular solidarity economy ventures, field diary aiming to record information and observation in formative, organizational and celebratory events of the ventures. Participation in the meetings of the Regional Forum on Solidarity Economy and the State Forum of Solidarity Economy. There was also privileged spaces for training and organization. The results show the role of women and the popular solidarity economy as a tool and instrument of participation, citizenship; productive inclusion, in search of well-being.Keywords: work; women; popular solidarity economy; well-being.
The Concept of Happiness in Max Frei’s Novel The Key of Yellow Metal: Hamlet and Siddhartha
Authors: Kanchura Yevheniia 
Published: December 2024

This article explores the motif of an ‘(un)happy prince’ as it is manifested through the evocation of Hamlet’s and Siddhartha’s imagery within Max Frei’s novel The Key of Yellow Metal (2009). The research offers an in-depth analysis of the functioning of these references within the broader intertextual landscape of the novel, placed within the Vilnius narrative. The theme of the happy prince's perception of human suffering is entwined with the topoi of hell and paradise, as well as home or lost paradise. Traditional imagery plays a pivotal role in shaping the concept of inspiration and madness as dynamic forces that exert a profound influence on the surrounding world, counterbalancing the notion of eternal suffering. The shift of focalization allows us to reconsider Sartre’s idea of ‘Hell is other people’. The paper emphasizes the role of the author as a narrator/reteller of well-known stories and tales, both for the author as an actual person and as a literary mystification. The article demonstrates the transformation of the fairy-tale notion of ‘happiness’ into the concept of acquiring meaning as a prerequisite of the main character’s individuation.
Predicting syntactic distribution from morphological structure: The PP syntax of converb clauses in Uralic and Turkic
Authors: Georgieva Ekaterina 
Published: December 2024

AbstractThis paper deals with converb clauses in Uralic and Turkic languages. These clauses are often defined in the typological literature as featuring a special non-finite verb type. The Uralic and Turkic data show, however, that many of the alleged converbs are in fact morphologically decomposable into a non-finite verb (nominalization, participle, etc.) and a case suffix. For these clauses, I put forward an analysis couched in a generative syntactic framework. I propose that we are dealing with a postpositional phrase (PP), in which the morphologically bound P head (the case suffix) select a non-finite clause. The PP analysis is supported by two case studies. Furthermore, it is demonstrated that this analysis makes correct predictions about the syntactic distribution of these clauses. The present proposal has thus bearing on what counts as a converb cross-linguistically.
Treatment of elderly patients with acute myeloid leukemia: personal experience
Authors: Shimanovskaya L. T. , Misyurina E. N. , Baryakh E. A. , Zhelnova E. I. , Yatskov K. V. , Chudnova T. S. , Tolstykh T. N. , Gagloeva D. E. 
Published: December 2024

Background. Acute myeloid leukemia (AML) is an aggressive malignancy of the hematopoietic system. Most patients with newly diagnosed AML are 65 years of age or older. Treatment of this cohort of patients is difficult due to the comorbidity of elderly patients and the genetic characteristics of hemoblastosis, which prevents the achievement of significant progress in treatment, in contrast to younger patients with AML. As domestic and foreign studies have shown, age is an independent universal prognosis factor for AML. In the era of targeted drugs, successful treatment of AML is becoming possible.Aim. To assess overall survival in elderly patients with AML, tolerability and effectiveness of various treatment regimens in patients with AML ≥65 years.Materials and methods. This paper presents our own experience in the treatment of elderly patients with AML in the hematology departments of the City Clinical Hospital No. 52. The study included patients over 65 years of age with AML from April 2022 to September 2023. A total of 40 patients were analyzed. To determine the risk factors for death, univariate and multivariate regression analyzes were performed using the logistic regression method. Variables that showed statistical significance on univariate analysis were included in the multivariate analysis. An analysis of 12‑month overall survival was also carried out using the Kaplan–Meier method with the construction of survival curves and calculation of median survival. A comparative analysis of two groups of patients treated with the AZA + EN and LdaraC regimens was carried out.Results. 63 % (n = 25) are men, 37 % (n = 15) are women. The median age was 75 years; all patients had complicated premorbid background. 53 % (n = 21) of patients were in the age range from 65 to 69 years, 47 % (n = 19) were over 70. Antitumor treatment was received by 88 % (n = 35) of patients. The remaining 5 underwent: best accompanying (n = 2), cytoreductive (early death at this stage) (n = 3) therapy. Complete remission after two cycles of therapy was achieved in 46 % (n = 16) of patients, and in 29 % (n = 10) it was maintained at the time of analysis. Early relapse occurred in 14 % (n = 5). Early mortality was recorded in 9 % (n = 3). Death was reported in 40 % (n = 16) of patients. 20 % (n = 7) of patients were refractory to first-line therapy, of which 36 % (n = 5) were treated with low doses of cytarabine (LdaraC), the rest to a combination of azacitidine (AZA) with venetoclax (EN). The number of relapses among patients on AZA + EN and LdaraC therapy was comparable.Conclusion. AZA + EN is the first-line treatment of choice in older patients with AML. The possibility of conducting this course in an outpatient setting makes it most convenient for both hematologists and patients. An important aspect in the treatment of AML in elderly patients is improving and maintaining quality of life.
El Impacto del Principio de Inembargabilidad de los Recursos del Sistema de Seguridad Social en Salud frente al Derecho a la Tutela Judicial Efectiva en Colombia
Authors: Castaño Quijano Juan Manuel 
Published: December 2024

The aim of this article of legal reflection is to determine the impact of the principle of the unseizability of the resources of the general social security health system on the right to effective judicial protection in Colombia. For this purpose, a qualitative legal research of a descriptive nature was carried out, using documentary and bibliographic techniques such as documentary, normative and jurisprudential analysis files, the results of which were studied from the teleological and systematic hermeneutics, which are aimed at determining the purpose of a complex set of norms.

With this, the structure of the General System of Social Security in Health in Colombia and the legal nature of its resources were identified, the Principle of Unattachability of Resources of the Social Security System in Health was studied, and the maxim of effective judicial protection in Colombia was examined. It was concluded that, while there is a general rule on the unseizability of health resources, there are also precise exceptions that must be applied in judicial practice in order to guarantee effective judicial protection. However, there is still a problem of non-compliance with the exceptions by the judiciary and administrative bodies.
La viabilidad de los juicios políticos contra funcionarios de elección popular desde la óptica del SIDH: Parámetros convencionales para su armonización
Authors: López Ruiz Faiber Andrés , Moreno Carreño Jorge Luis , Hernández Granados Liany Yetzira 
Published: December 2024

Currently, there is controversy within the specialized doctrine about the legitimacy of political trials in accordance with the postulates arising from the American Convention on Human Rights, due to legal uncertainty about a specific regulation and the absence of jurisprudential development within the Inter-American System that functions as a scale to determine the Conventionality of this means of political control, which exists in most countries belonging to the Inter-American System. In this sense, the main objective of this article is aimed at establishing objective parameters that allow the harmonization of political trials with the ACHR. For this purpose, a contextualization of the genesis of this means of political control was carried out through a qualitative methodology, as well as its transfer in the panorama of Latin American constitutional law and, finally, the requirements that allow impeachment to coexist harmoniously with conventional requirements were addressed in a diaphanous way, having as a catalyst the teleological criteria mutatis mutandis within the framework of international guarantees decanted in the Corpus Iuris of International Law of Human Rights.
A dimensão do cuidado do pós operatório de fratura de fêmur em idosos: uma revisão integrativa
Authors: Coan Fernanda Fernandes , Campelo Sabrina de Sousa , Vasconcelos Caio Brandão e , Loyola Cristina Maria Douat 
Published: December 2024

Trata-se de uma revisão integrativa que busca enumerar e compreender pelas revisões de literatura as circunstâncias que permeiam o pós-operatório da fratura de fêmur. A revisão do processo baseou-se nas recomendações da lista de conferência do Rayyan Enterprise, Faster Sistematic Review. Foram examinados artigos publicados entre 2010 e 2023 que fizessem estudo qualitativo relacionado à fratura de quadril em idosos. As buscas ocorreram em agosto nas bases de dados Pubmed, MEDLINE, Scopus e Capes. A seleção compreendeu três etapas: busca, pré-seleção e inclusão de artigos. Foram utilizados os seguintes descritores em ciências da saúde (DeCS): (hip fracture) AND (elderly) AND (qualitative). Foram identificados 41 artigos nas bases de dados pesquisadas através das estratégias de busca. Após leitura dos títulos e resumos, 25 artigos foram considerados potencialmente elegíveis para inclusão no estudo e foram recuperados para leitura na íntegra. Após a leitura completa, os 9 artigos foram selecionados mediante aplicação dos critérios de inclusão e exclusão estabelecido. O pós-operatório da fratura de fêmur em idosos é um momento frágil que gera a experiência de uma nova rotina e a incerteza de uma recuperação de suas atividades fisiológicas do passado. A concepção dos profissionais de saúde e cuidadores são decisivos para sua melhor recuperação.
FAKTOR YANG MEMPENGARUHI TINGKAT KEMISKINAN DI PULAU MADURA
Authors: Pratiwi Fina Novianti , Istiyani Nanik , Jumiati Aisah 
Published: December 2024

Kemiskinan merupakan ketidakmampuan dari sisi ekonomi dalam mencukupi keperluan dasar makanan dan bukan makanan yang di takar atas pengeluaran. Salah satu persentase kemiskinan terbesar di Provinsi Jawa Timur adalah Pulau Madura. Kabupaten yang ada di Pulau Madura memiliki rata-rata tingkat kemiskinan yang masih tergolong tinggi jika dibandingkan dengan rata-rata tingkat kemiskinan yang berada di provinsi Jawa Timur. Penelitian ini bertujuan untuk menganalisis pengaruh Tingkat Pengangguran Terbuka, Jumlah Penduduk, dan Kualitas Penduduk terhadap tingkat kemiskinan di Pulau Madura pada tahun 2012-2021. Metode analisis yang digunakan dalam penelitian ini adalah Analisis Regresi Data Panel dengan pendekatan Fixed Effect Model (FEM). Hasil penelitian ini menunjukkan bahwa variabel Tingkat Pengangguran Terbuka berpengaruh positif dan signifikan terhadap tingkat kemiskinan, variabel jumlah penduduk berpengaruh negatif dan tidak signifikan terhadap tingkat kemiskinan, dan variabel kualitas penduduk berpengaruh negatif dan signifikan terhadap tingkat kemiskinan di Pulau Madura.
Kata Kunci: Kemiskinan, Tingkat Pengangguran Terbuka, Jumlah Penduduk, Kualitas Penduduk
ENHANCING TUBERCULOSIS CASE FINDING THROUGH SULI SIMULATOR APP: A CASE STUDY IN LUBUKLINGGAU CITY, SOUTH SUMATERA PROVINCE, INDONESIA
Authors: Kurniawan Depit , Syakurah Rizma Adlia 
Published: December 2024

Introduction: Tuberculosis (TB) remains a significant public health challenge and is included as one of the targets in the Sustainable Development Goals (SDGs). TB case finding in Lubuklinggau City decreased from 967 in 2019 to 273 (24,37%) in 2020. Aims: This study aims to analyze the TB disease management program strategy implementation in contact investigation activities by utilizing the SULI SIMULATOR application. Method: A qualitative design with a participatory action research (PAR) approach was employed, involving focus group discussions, in-depth interviews with 36 informants, and document review. Data were validated using triangulation methods and sources, followed by thematic analysis. Result: The findings revealed that, in terms of input, some PHC lacked analysts in their human resources. In terms of process, the successful implementation of the TB disease prevention program, with the application of SULI SIMULATOR for TB contact investigation, led to an increase in the case detection rate (CDR) to 255 cases (22.76%) in 2021 compared to the previous year's 237 patients (21.16%). Conclusion: The active involvement of the community and family is crucial in promoting early detection of TB cases through contact investigation activities, as well as providing support for treatment in family and community-based health efforts