bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Quest of a Coherent Portrait of Paul: A Rejoinder to Michael Bird
Authors: Kaminsky Joel , Reasoner Mark 
Published: October 2020

AbstractThis rejoinder to Michael Bird’s critique of our argument in Joel Kaminsky and Mark Reasoner, “The Meaning and Telos of Israel’s Election: An Interfaith Response to N. T. Wright’s Reading of Paul,” HTR 112 (2019) 421–46, acknowledges that Wright recognizes a dimension of intrinsic value in God’s election of Israel, while it shows how Wright’s metanarrative is not only unduly skewed toward an instrumental view of Israel’s election but also, in effect, totally redefines Israel. Our rebuttal first reiterates some of our original claims and also presents new arguments against an exegesis of Second Isaiah that portrays Israel as divinely called to bring light or Torah to the nations. Later Second Temple sources also did not understand Israel as failing to fulfill a divine call to missionize the gentiles. Bird’s own inconsistency on the mission orientation of Israel weakens his defense of Wright here. Wright’s exegesis of Rom 5:20–21 as teaching that God intentionally gave Torah to draw the world’s sins onto Israel and Bird’s defense of this on the basis of Isaiah 53 are anomalous and untenable in the light of other scholars’ readings of Romans and the rest of the New Testament. Finally, against Bird, Wright does indeed read non-Christ-confessing Jews out of Israel in a highly problematic way. Bird’s agreement with us against Wright that “all Israel” in Rom 11:26 refers to corporeal Israel strengthens our original critique of Wright’s redefinition of Israel in Rom 9–11.
The Cal-DSH diversion guidelines
Authors: Cummings Michael A. , Scott Charles , Arguello Juan Carlos , Arias Ai-Li W. , Breth Ashley M. , Delgado Darci , Harvey Phil D. , Meyer Jonathan M. , O’Day Jennifer , Pollock Megan , Proctor George , Rector Tiffany , Rose Benjamin , Schwartz Eric , Thordarson Helga , Warburton Katherine , Stahl Stephen M. 
Published: October 2020

AbstractThe Cal-DSH Diversion Guidelines provide 10 general guidelines that jurisdictions should consider when developing diversion programs for individuals with a serious mental illness (SMI) who become involved in the criminal justice system. Screening for SMI in a jail setting is reviewed. In addition, important treatment interventions for SMI and substance use disorders are highlighted with the need to address criminogenic risk factors highlighted.
Nutrient density and affordability of foods in Brazil by food group and degree of processing
Authors: Siqueira Kennya Beatriz , Borges Cristiano AV , Binoti Mirella L , Pilati Amanda F , da Silva Paulo HF , Gupta Shilpi , Drewnowski Adam 
Published: October 2020

AbstractObjective:Affordable nutrition refers to the relation between nutrient density of foods and their monetary cost. There are limited data on affordable nutrition in low- and middle-income countries. The present study aimed to develop a nutrient density score and nutrient affordability metrics for 377 most consumed foods in Brazil.Design:The foods were aggregated into seven major food groups and four NOVA food categories. Nutrient composition data were obtained from the Brazilian Institute of Geography and Statistics. Food prices were obtained from retailer websites and were converted to prices per 100 g and 418 kJ. The Nutrient Rich Food (NRF8.2) score was based on protein, fiber, vitamins A, C and E, Ca, Fe and K. Nutrients to limit were sugar and Na. Affordability was measured as kcal/R$ and nutrients/R$.Results:Grains, fats and sweets were more energy dense and had lower NRF8.2 scores than dairy, vegetables and fruits. Grains, fats and sweets were the lowest cost sources of energy. Vegetables and fruits, beans, nuts and seeds and eggs and dairy were the lowest cost sources of multiple nutrients. Ultra-processed foods (48 % of total) had higher energy density and lower NRF8.2 scores than did unprocessed foods. In Brazil, fruits, vegetables and dairy products offered the most nutrients per real.Conclusions:Analysis of the relationship between nutrient density of foods and their cost can help identify locally available foods that are nutrient rich, affordable and culturally acceptable. Achieving high nutrient density at an affordable cost should be the goal of Brazil’s food systems.
Super High Frequency Events: A New Class of Events Recorded by the InSight Seismometers on Mars
Authors: Dahmen Nikolaj L. , Clinton John F. , Ceylan Savas , van Driel Martin , Giardini Domenico , Khan Amir , Stähler Simon C. , Böse Maren , Charalambous Constantinos , Horleston Anna , Kawamura Taichi , Orhand‐Mainsant Guenolé , Scholz John‐Robert , Euchner Fabian , Pike William T. , Weber Renee C. , Lognonné Philippe , Banerdt William B. 
Published: October 2020

AbstractWe present a new class of seismic signals that are recorded by the seismometer placed on the surface of Mars as part of the NASA InSight mission. The signals, termed super high frequency (SF) events, are of short duration (∼20 s), are often similar in amplitude, and feature high‐frequency energy between ∼5 and 30 Hz that is dominant on the horizontal components. For detection and characterization of SF events, we employ the available continuous 20 samples per second (sps) data from the Very Broadband instrument. Due to bandwidth limitations, 100 sps data from the short‐period sensor are only partially obtainable, but they aid in analysis of the frequency content above 10 Hz and in distinguishing the events from high‐frequency noise. From June 2019 to May 2020, 780 SF events have been detected. The events observed occur in repeatable patterns that last for weeks. Initially, the SF events were clustered in the hours before sunset, but more recently, they have been distributed across the evening period. Based on template matching techniques, we have identified 16 distinct families that generally follow the temporal clusters. A thermal origin of these events is suggested, since the majority of the events fall within a ±2 h time window around sunset with extreme temperature changes. The SF events have similarities with thermal events observed on the lunar surface from data collected during the Apollo missions.
Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma
Authors: Hu Qinchao , Peng Jianmin , Jiang Laibo , Li Wuguo , Su Qiao , Zhang Jiayu , Li Huan , Song Ming , Cheng Bin , Xia Juan , Wu Tong 
Published: October 2020

AbstractCDK4/6 inhibitors show promising antitumor activity in a variety of solid tumors; however, their role in head and neck squamous cell carcinoma (HNSCC) requires further investigation. The senescence-associated secretory phenotype (SASP) induced by CDK4/6 inhibitors has dual effects on cancer treatment. The need to address the SASP is a serious challenge in the clinical application of CDK4/6 inhibitors. We investigated whether metformin can act as a senostatic drug to modulate the SASP and enhance the anticancer efficacy of CDK4/6 inhibitors in HNSCC. In this study, the efficacy of a combination of the CDK4/6 inhibitor LY2835219 and metformin in HNSCC was investigated in in vitro assays, an HSC6 xenograft model, and a patient-derived xenograft model. Senescence-associated β-galactosidase staining, antibody array, sphere-forming assay, and in vivo tumorigenesis assay were used to detect the impacts of metformin on the senescence and SASP induced by LY2835219. We found that LY2835219 combined with metformin synergistically inhibited HNSCC by inducing cell cycle arrest in vitro and in vivo. Metformin significantly modulated the profiles of the SASP elicited by LY2835219 by inhibiting the mTOR and stat3 pathways. The LY2835219-induced SASP resulted in upregulation of cancer stemness, while this phenomenon can be attenuated when combined with metformin. Furthermore, results showed that the stemness inhibition by metformin was associated with blockade of the IL6-stat3 axis. Survival analysis demonstrated that overexpression of IL6 and stemness markers was associated with poor survival in HNSCC patients, indicating that including metformin to target these proteins might improve patient prognosis. Collectively, our data suggest that metformin can act as a senostatic drug to enhance the anticancer efficacy of CDK4/6 inhibitors by reprogramming the profiles of the SASP.
Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
Authors: Wang Yizhuo , Zhao Meng , Liu Shuyun , Guo Jun , Lu Yanrong , Cheng Jingqiu , Liu Jingping 
Published: October 2020

AbstractMacrophages (Mφ) are primary innate immune cells that exhibit diverse functions in response to different pathogens or stimuli, and they are extensively involved in the pathology of various diseases. Extracellular vesicles (EVs) are small vesicles released by live cells. As vital messengers, macrophage-derived EVs (Mφ-EVs) can transfer multiple types of bioactive molecules from macrophages to recipient cells, modulating the biological function of recipient cells. In recent years, Mφ-EVs have emerged as vital mediators not only in the pathology of multiple diseases such as inflammatory diseases, fibrosis and cancers, but also as mediators of beneficial effects in immunoregulation, cancer therapy, infectious defense, and tissue repair. Although many investigations have been performed to explore the diverse functions of Mφ-EVs in disease pathology and intervention, few studies have comprehensively summarized their detailed biological roles as currently understood. In this review, we briefly introduced an overview of macrophage and EV biology, and primarily focusing on current findings and future perspectives with respect to the pathological and therapeutic effects of Mφ-EVs in various diseases.
Inter-hemispheric synchroneity of Holocene precipitation anomalies controlled by Earth’s latitudinal insolation gradients
Authors: Deininger Michael , McDermott Frank , Cruz Francisco W. , Bernal Juan Pablo , Mudelsee Manfred , Vonhof Hubert , Millo Christian , Spötl Christoph , Treble Pauline C. , Pickering Robyn , Scholz Denis 
Published: October 2020

AbstractAtmospheric circulation is a fundamental component of Earth’s climate system, transporting energy poleward to partially offset the latitudinal imbalance in insolation. Changes in the latitudinal distribution of insolation thus force variations in atmospheric circulation, in turn altering regional hydroclimates. Here we demonstrate that regional hydroclimates controlled by the Northern Hemisphere mid-latitude storm tracks and the African and South American Monsoons changed synchronously during the last 10 kyrs. We argue that these regional hydroclimate variations are connected and reflect the adjustment of the atmospheric poleward energy transport to the evolving differential heating of the Northern and Southern Hemispheres. These results indicate that changes in latitudinal insolation gradients and associated variations in latitudinal temperature gradients exert important control on atmospheric circulation and regional hydroclimates. Since the current episode of global warming strongly affects latitudinal temperature gradients through Arctic amplification, our results can inform projections of likely inter-hemispheric precipitation changes in the future.
Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
Authors: Kim Jiyoung , Kang Jengmin , Kang Ye-Lim , Woo Jongmin , Kim Youngsoo , Huh June , Park Jong-Wan 
Published: October 2020

AbstractHarmful effects of high fructose intake on health have been widely reported. Although fructose is known to promote cancer, little is known about the underlying mechanisms. Here, we found that fructose triggers breast cancer metastasis through the ketohexokinase-A signaling pathway. Molecular experiments showed that ketohexokinase-A, rather than ketohexokinase-C, is necessary and sufficient for fructose-induced cell invasion. Ketohexokinase-A-overexpressing breast cancer was found to be highly metastatic in fructose-fed mice. Mechanistically, cytoplasmic ketohexokinase-A enters into the nucleus during fructose stimulation, which is mediated by LRRC59 and KPNB1. In the nucleus, ketohexokinase-A phosphorylates YWHAH at Ser25 and the YWHAH recruits SLUG to the CDH1 promoter, which triggers cell migration. This study provides the effect of nutrition on breast cancer metastasis. High intake of fructose should be restricted in cancer patients to reduce the risk of metastasis. From a therapeutic perspective, the ketohexokinase-A signaling pathway could be a potential target to prevent cancer metastasis.
Immune modulatory effects of oncogenic KRAS in cancer
Authors: Hamarsheh Shaima’a , Groß Olaf , Brummer Tilman , Zeiser Robert 
Published: October 2020

AbstractOncogenic KRAS mutations are the most frequent mutations in human cancer, but most difficult to target. While sustained proliferation caused by oncogenic KRAS-downstream signalling is a main driver of carcinogenesis, there is increasing evidence that it also mediates autocrine effects and crosstalk with the tumour microenvironment (TME). Here, we discuss recent reports connecting KRAS mutations with tumour-promoting inflammation and immune modulation caused by KRAS that leads to immune escape in the TME. We discuss the preclinical work on KRAS-induced inflammation and immune modulation in the context of currently ongoing clinical trials targeting cancer entities that carry KRAS mutations and strategies to overcome the oncogene-induced effects on the immune system.
Nondestructive analysis of alterations of Chinese jade artifacts from Jinsha, Sichuan Province, China
Authors: Bao Yi , Yun Xuemei , Zhao Chaohong , Wang Fang , Li Yuesheng 
Published: October 2020

AbstractJade, which is one of the most characteristic materials constituting Chinese artifacts, signifies cultural differences between ancient Chinese and western civilizations. One of the most important typical characteristics of ancient jade artifacts recovered through archeological excavations is color alterations due to human activity and natural weathering, which has led to an area of intensive research in archeology. “Alteration” refers to chemical component and structural changes in jade artifacts caused by human activity and natural weathering, which is different from the term in geology. In this study, Raman spectroscopy was used to analyze six color alterations on ancient jade artifacts unearthed from the Jinsha Site in Sichuan Province, a region famous for artifacts with colorful alterations. The colorful alterations were observed to originate from corrosion products of bronzeware. The green, black, yellow, blue, purple, and white alterations were due to malachite, tenorite, pyromorphite, azurite, diaboleite, and cassiterite, respectively. Meanwhile, organic matter and hypertoxic arsenolite were first found on ancient jade artifacts.
Current and historic HIV-1 molecular epidemiology in paediatric and adult population from Kinshasa in the Democratic Republic of Congo
Authors: Rubio-Garrido Marina , González-Alba José María , Reina Gabriel , Ndarabu Adolphe , Barquín David , Carlos Silvia , Galán Juan Carlos , Holguín África 
Published: October 2020

AbstractHIV-1 diversity may impact monitoring and vaccine development. We describe the most recent data of HIV-1 variants and their temporal trends in the Democratic Republic of Congo (DRC) from 1976 to 2018 and in Kinshasa from 1983–2018. HIV-1 pol sequencing from dried blood collected in Kinshasa during 2016–2018 was done in 340 HIV-infected children/adolescents/adults to identify HIV-1 variants by phylogenetic reconstructions. Recombination events and transmission clusters were also analyzed. Variant distribution and genetic diversity were compared to historical available pol sequences from the DRC in Los Alamos Database (LANL). We characterized 165 HIV-1 pol variants circulating in Kinshasa (2016–2018) and compared them with 2641 LANL sequences from the DRC (1976–2012) and Kinshasa (1983–2008). During 2016–2018 the main subtypes were A (26.7%), G (9.7%) and C (7.3%). Recombinants accounted for a third of infections (12.7%/23.6% Circulant/Unique Recombinant Forms). We identified the first CRF47_BF reported in Africa and four transmission clusters. A significant increase of subtype A and sub-subtype F1 and a significant reduction of sub-subtype A1 and subtype D were observed in Kinshasa during 2016–2018 compared to variants circulating in the city from 1983 to 2008. We provide unique and updated information related to HIV-1 variants currently circulating in Kinshasa, reporting the temporal trends of subtypes/CRF/URF during 43 years in the DRC, and providing the most extensive data on children/adolescents.
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila
Authors: Scholes Harry M. , Cryar Adam , Kerr Fiona , Sutherland David , Gethings Lee A. , Vissers Johannes P. C. , Lees Jonathan G. , Orengo Christine A. , Partridge Linda , Thalassinos Konstantinos 
Published: October 2020

AbstractAlzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Understanding the molecular pathology of AD during disease progression may identify new ways to reduce neuronal damage. Here, we present a longitudinal study tracking dynamic proteomic alterations in the brains of an inducible Drosophila melanogaster model of AD expressing the Arctic mutant Aβ42 gene. We identified 3093 proteins from flies that were induced to express Aβ42 and age-matched healthy controls using label-free quantitative ion-mobility data independent analysis mass spectrometry. Of these, 228 proteins were significantly altered by Aβ42 accumulation and were enriched for AD-associated processes. Network analyses further revealed that these proteins have distinct hub and bottleneck properties in the brain protein interaction network, suggesting that several may have significant effects on brain function. Our unbiased analysis provides useful insights into the key processes governing the progression of amyloid toxicity and forms a basis for further functional analyses in model organisms and translation to mammalian systems.
Diminished corticomotor excitability in Gulf War Illness related chronic pain symptoms; evidence from TMS study
Authors: Lei Karen , Kunnel Alphonsa , Metzger-Smith Valerie , Golshan Shahrokh , Javors Jennifer , Wei Jennie , Lee Roland , Vaninetti Michael , Rutledge Thomas , Leung Albert 
Published: October 2020

AbstractChronic diffuse body pain is unequivocally highly prevalent in Veterans who served in the 1990–91 Persian Gulf War and diagnosed with Gulf War Illness (GWI). Diminished motor cortical excitability, as a measurement of increased resting motor threshold (RMT) with transcranial magnetic stimulation (TMS), is known to be associated with chronic pain conditions. This study compared RMT in Veterans with GWI related diffuse body pain including headache, muscle and joint pain with their military counterparts without GWI related diffuse body pain. Single pulse TMS was administered over the left motor cortex, using anatomical scans of each subject to guide the TMS coil, starting at 25% of maximum stimulator output (MSO) and increasing in steps of 2% until a motor response with a 50 µV peak to peak amplitude, defined as the RMT, was evoked at the contralateral flexor pollicis brevis muscle. RMT was then analyzed using Repeated Measures Analysis of Variance (RM-ANOVA). Veterans with GWI related chronic headaches and body pain (N = 20, all males) had a significantly (P < 0.001) higher average RMT (% ± SD) of 77.2% ± 16.7% compared to age and gender matched military controls (N = 20, all males), whose average was 55.6% ± 8.8%. Veterans with GWI related diffuse body pain demonstrated a state of diminished corticomotor excitability, suggesting a maladaptive supraspinal pain modulatory state. The impact of this observed supraspinal functional impairment on other GWI related symptoms and the potential use of TMS in rectifying this abnormality and providing relief for pain and co-morbid symptoms requires further investigation.Trial registration: This study was registered on January 25, 2017, on ClinicalTrials.gov with the identifier: NCT03030794. Retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT03030794.
Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: investigation of relationships between polymer structure and performance
Authors: Wilson Venecia R. , Lou Xiaochun , Osterling Donald J. , Stolarik DeAnne F. , Jenkins Gary J. , Nichols Brittany L. B. , Dong Yifan , Edgar Kevin J. , Zhang Geoff G. Z. , Taylor Lynne S. 
Published: October 2020

AbstractAmorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead to the generation and maintenance of supersaturated solutions, which enhance oral absorption in vivo, are poorly understood. Herein, a diverse group of newly synthesized cellulose derivatives was evaluated for their ability to inhibit crystallization of enzalutamide, a poorly soluble compound used to treat prostate cancer. ASDs were prepared from selected polymers, specifically a somewhat hydrophobic polymer that was extremely effective at inhibiting drug crystallization, and a less effective, but more hydrophilic, crystallization inhibitor, that might afford better release. Drug membrane transport rate was evaluated in vitro and compared to in vivo performance, following oral dosing in rats. Good correlation was noted between the in vitro diffusion cell studies and the in vivo data. The ASD formulated with the less effective crystallization inhibitor outperformed the ASD prepared with the highly effective crystallization inhibitor in terms of the amount and rate of drug absorbed in vivo. This study provides valuable insight into key factors impacting oral absorption from enabling ASD formulations, and how best to evaluate such formulations using in vitro approaches.
Lithium containing layered high entropy oxide structures
Authors: Wang Junbo , Cui Yanyan , Wang Qingsong , Wang Kai , Huang Xiaohui , Stenzel David , Sarkar Abhishek , Azmi Raheleh , Bergfeldt Thomas , Bhattacharya Subramshu S. , Kruk Robert , Hahn Horst , Schweidler Simon , Brezesinski Torsten , Breitung Ben 
Published: October 2020

AbstractLayered Delafossite-type Lix(M1M2M3M4M5…Mn)O2 materials, a new class of high-entropy oxides, were synthesized by nebulized spray pyrolysis and subsequent high-temperature annealing. Various metal species (M = Ni, Co, Mn, Al, Fe, Zn, Cr, Ti, Zr, Cu) could be incorporated into this structure type, and in most cases, single-phase oxides were obtained. Delafossite structures are well known and the related materials are used in different fields of application, especially in electrochemical energy storage (e.g., LiNixCoyMnzO2 [NCM]). The transfer of the high-entropy concept to this type of materials and the successful structural replication enabled the preparation of novel compounds with unprecedented properties. Here, we report on the characterization of a series of Delafossite-type high-entropy oxides by means of TEM, SEM, XPS, ICP-OES, Mössbauer spectroscopy, XRD including Rietveld refinement analysis, SAED and STEM mapping and discuss about the role of entropy stabilization. Our experimental data indicate the formation of uniform solid-solution structures with some Li/M mixing.