bluuebunny/crossref_metadata_2025_split huggingface dataset:
The novel long noncoding RNA lncRNA-Adi regulates adipogenesis
Authors: Chen Yuanwei , Li Kaide , Zhang Xiao , Chen Jinlong , Li Meisheng , Liu Lei 
Published: May 2020

Abstract
Adipogenesis participates in many physiological and pathological processes, such as obesity and diabetes, and is regulated by a series of precise molecular events. However, the molecules involved in this regulation have not been fully characterized. In this study, we identified a long noncoding (lnc)RNA, lncRNA-Adi, which is highly expressed in adipose tissue-derived stromal cells (ADSCs) that are differentiating into adipocytes. Knockdown of lncRNA-Adi impaired the adipogenic differentiation ability of ADSCs. Moreover, lncRNA-Adi was found to interact with microRNA (miR)-449a to enhance the expression of cyclin-dependent kinase (CDK)6 during adipogenesis. The mechanism by which lncRNA-Adi regulates adipogenesis was determined to involve an lncRNA-Adi-miR-449a interaction that competes with the CDK6 3′ untranslated region to increase CDK6 translation and activate the pRb-E2F1 pathway to promote adipogenesis. These findings provide valuable information and a new study angle to search for therapeutic targets against metabolic disorders such as obesity and diabetes.

Significance statement This study found a new lncRNA, which was named lncRNA-Adi, that highly expressed in adipogenic-induced ADSCs. Furthermore, lncRNA-Adi could competitively interact with miR-449a, which protects CDK6 from degradation by miR-449a, to improve CDK6 translation level and activate pRb-E2F1 pathway, which is crucial to cell proliferation in the early stage of adipogenesis, to promote adipogenesis. These findings not only revealed the function and mechanism of lncRNA-Adi in regulating adipogenesis but also, more importantly, could provide valuable information and a new study angle in the future to search for therapeutic target in fighting against metabolic disorders such as obesity and diabetes.
Does government health insurance reduce job lock and job push?
Authors: Barkowski Scott 
Published: May 2020

AbstractI study job lock and job push, twin phenomena believed to be partially due to employment‐contingent health insurance (ECHI). Using variation in Medicaid eligibility among household members of male workers to identify changes in those workers' reliance on ECHI, I estimate notable job lock and job push effects. For married male workers, a 15 percentage point increase in the likelihood a household member is eligible for Medicaid increases the rate of voluntary job exits over a four‐month period by 14%. For job push, the same increase in a household member's likelihood of Medicaid eligibility reduces the transition rate into jobs with ECHI among all male workers by 8%.
Relations Between Literacy Research and Practice in New Zealand
Authors: Parr Judy M. , Jesson Rebecca 
Published: May 2020

AbstractTeaching as a process of inquiry is the underpinning philosophy stated in the New Zealand Curriculum. Teachers are tasked with inquiring into the needs of their students and the efficacy of their own practice in the light of those needs. The results of ongoing inquiry inform how practice might be honed or changed. The authors consider how the context influences the ways in which teachers interact with research and with researchers to inform and support this inquiry. Although drawing on multiple literacy research endeavors with practitioners, the authors employ just one example of a partnership that focused on accelerating progress, particularly for underachieving writers ages 10–13, to illustrate how practices that were effective with these writers were jointly established.
Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy
Authors: Salama Mohamed , Akan Ahmet , Mueller Michael Rolf 
Published: May 2020

AbstractObjectivesSystemic inflammation is a potentially debilitating complication of thoracic surgeries with significant physical and economic morbidity. There is compelling evidence for the role of the central nervous system in regulating inflammatory processes through humoral mechanisms. Activation of the afferent vagus nerve by cytokines triggers anti‐inflammatory responses. Peripheral electrical stimulation of the vagus nerve in vivo during lethal endotoxemia in rats inhibited tumor necrosis factor synthesis and prevented shock development. However, the vagal regulatory role of systemic inflammation after lung lobectomy is unknown.MethodsOne hundred patients who underwent lobectomy via thoracotomy were recruited and equally randomized to treated group or controls. Intermittent stimulation of the auricular branch of vagus nerve in the triangular fossa was applied in the treated group using neurostimulator V (Ducest®, Germany), starting 24 h preoperatively and continued till the 4th postoperative day (POD). Inflammatory interleukins (IL) were analyzed using ELISA preoperatively, on the 1st and 4th POD.ResultsOn the 1st POD, patients who underwent neurostimulation had reduced serum concentrations of CRP (p = 0.01), IL6 (p = 0.02) but elevated IL10 (p = 0.03) versus controls. On the 4th POD, serum concentrations of CRP, IL6 and IL10 were similar in both groups. Moreover, the treated group was associated with lower incidence of pneumonia (p = 0.04) and shorter hospitalization time (p = 0.04) versus controls.ConclusionsModulations in the brain stem caused by noninvasive transcutaneous stimulation of the vagus nerve after lung lobectomy attenuate the acute postsurgical inflammatory response by the regulation of IL6 and IL10, resulting in reduced incidence of postoperative pneumonia and short hospitalization time.Clinical Trial Registry NumberNCT03204968.
Modern scaffolding strategies based on naturally pre-fabricated 3D biomaterials of poriferan origin
Authors: Tsurkan Dmitry , Wysokowski Marcin , Petrenko Iaroslav , Voronkina Alona , Khrunyk Yuliya , Fursov Andriy , Ehrlich Hermann 
Published: May 2020

AbstractModern scaffolding strategies include two key ways: to produce requested 3D constructs from corresponding precursors using technological tools, or simply use naturally already pre-fabricated scaffolds if they originate from renewable sources. Marine sponges inhabit oceans since the Precambrian. These ancient multicellular organisms possess a broad variety of evolutionary approved and ready to use skeletal structures, which seem to be well applicable as 3D scaffolds in diverse fields of modern bioinspired materials science, biomimetics and regenerative medicine. In this review, most attention is paid to biosilica-, chitin-, and spongin-based scaffolds of poriferan origin with respect to their potential use.
Lifestyle among long-term survivors of cancers in young adulthood
Authors: Bøhn Synne-Kristin H. , Lie Hanne C. , Reinertsen Kristin V. , Fosså Sophie D. , Haugnes Hege S. , Kiserud Cecilie E. , Loge Jon Håvard , Wisløff Torbjørn , Thorsen Lene 
Published: May 2020

Abstract
Purpose
To investigate lifestyle in a population-based sample of long-term (≥ 5 years since diagnosis) young adult cancer survivors (YACSs), and explore factors associated with not meeting the lifestyle guidelines for physical activity (PA), body mass index (BMI), and smoking.

Methods
YACSs (n = 3558) diagnosed with breast cancer (BC), colorectal cancer (CRC), non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia (ALL), or localized malignant melanoma (MM) between the ages of 19 and 39 years and treated between 1985 and 2009 were invited to complete a mailed questionnaire. Survivors of localized MM treated with limited skin surgery served as a reference group for treatment burden.

Results
In total, 1488 YACSs responded (42%), and 1056 YACSs were evaluable and included in the present study (74% females, average age at survey 49 years, average 15 years since diagnosis). Forty-four percent did not meet PA guidelines, 50% reported BMI ≥ 25 and 20% smoked, with no statistically significant differences across diagnostic groups. Male gender, education ≤ 13 years, comorbidity, lymphedema, pain, chronic fatigue, and depressive symptoms were associated with not meeting single and/or an increasing number of lifestyle guidelines.

Conclusion
A large proportion of long-term YACSs do not meet the lifestyle guidelines for PA, BMI, and/or smoking. Non-adherence to guidelines is associated with several late effects and/or comorbidities that should be considered when designing lifestyle interventions for YACSs.
Stimulus–effect relations for left ventricular growth obtained with a simple multi-scale model: the influence of hemodynamic feedback
Authors: Rondanina Emanuele , Bovendeerd Peter H. M. 
Published: May 2020

AbstractCardiac growth is an important mechanism for the human body to respond to changes in blood flow demand. Being able to predict the development of chronic growth is clinically relevant, but so far models to predict growth have not reached consensus on the stimulus–effect relation. In a previously published study, we modeled cardiac and hemodynamic function through a lumped parameter approach. We evaluated cardiac growth in response to valve disease using various stimulus–effect relations and observed an unphysiological decline pump function. Here we extend that model with a model of hemodynamic feedback that maintains mean arterial pressure and cardiac output through adaptation of peripheral resistance and circulatory unstressed volume. With the combined model, we obtain stable growth and restoration of pump function for most growth laws. We conclude that a mixed combination of stress and strain stimuli to drive cardiac growth is most promising since it (1) reproduces clinical observations on cardiac growth well, (2) requires only a small, clinically realistic adaptation of the properties of the circulatory system and (3) is robust in the sense that results were fairly insensitive to the exact choice of the chosen mechanics loading measure. This finding may be used to guide the choice of growth laws in more complex finite element models of cardiac growth, suitable for predicting the response to spatially varying changes in tissue load. Eventually, the current model may form a basis for a tool to predict patient-specific growth in response to spatially homogeneous changes in tissue load, since it is computationally inexpensive.
Comparative genetic analysis of grayling (Thymallus spp. Salmonidae) across the paleohydrologically dynamic river drainages of the Altai-Sayan mountain region
Authors: Weiss Steven , Grimm Jacqueline , Gonçalves Duarte V. , Secci-Petretto Giulia , Englmaier Gernot K. , Baimukanov Mirgaliy , Froufe Elsa 
Published: May 2020

AbstractA high number of grayling (Thymallus) species have been described from the Altai-Sayan mountain region, for which little to no genetic information is available. We investigated genetic relationships within this genus of salmonid fishes using mtDNA and microsatellite markers. The analysis focused on three putative species, Markakol grayling (T. brevicephalus), Upper Ob grayling (T. nikolskyi) and Mongolian grayling (T. brevirostris). We integrated these data with mtDNA sequences from eight other grayling species, including two of geographic proximity to the study area. Phylogenetic results revealed three pairs of reciprocally monophyletic sister species, two of which were phylogenetically juxtaposed across isolated drainage systems. Based on microsatellite analysis (up to 10 loci) no evidence of hybridization or introgression was found among species, supporting the mtDNA phylogeny. Based on a time-calibrated tree, divergence times between the focal taxa ranged from 0.36 to 1.1 MY. The genetic data support the distinction of these species and underscore the importance of paleohydrological dynamics in this biogeographically complex region. Well-documented mega-flood events in the region provide a model of how the contemporary cross-basin distribution of these species may have evolved.
Cultivation conditions affect the monosaccharide composition in Ulva fenestrata
Authors: Olsson Joakim , Toth Gunilla B. , Oerbekke Annelous , Cvijetinovic Suzana , Wahlström Niklas , Harrysson Hanna , Steinhagen Sophie , Kinnby Alexandra , White Joel , Edlund Ulrica , Undeland Ingrid , Pavia Henrik , Albers Eva 
Published: May 2020

AbstractIn recent years, the interest in using seaweed for the sustainable production of commodities has been increasing as seaweeds contain many potentially worthwhile compounds. Thus, the extraction and refining processes of interesting compounds from seaweeds is a hot research topic but has been found to have problems with profitability for novel applications. To increase the economic potential of refining seaweed biomass, the content of the compounds of interest should be maximized, which can potentially be achieved through optimization of cultivation conditions. In this study, we studied how the monosaccharide composition of the green seaweed speciesUlva fenestratais influenced by the abiotic factors; irradiance, temperature, nitrate, phosphate, and pCO2. It was evident that lower nitrate concentration and cultivation at elevated temperature increased monosaccharide contents. A 70% increase in iduronic acid and a 26% increase in rhamnose content were seen under elevated irradiance and temperature conditions, though the absolute differences in monosaccharide concentration were small. Irradiance and nitrate impacted the ratio between iduronic and rhamnose, which is an indicator of the ulvan structure. These results could potentially be utilized to coax the ulvan towards specific bioactivities, and thus have a considerable impact on a potential biorefinery centered aroundUlva.
A comparison between water uptake and root length density in winter wheat: effects of root density and rhizosphere properties
Authors: Zhang X. X. , Whalley P. A. , Ashton R. W. , Evans J. , Hawkesford M. J. , Griffiths S. , Huang Z. D. , Zhou H. , Mooney S. J. , Whalley W. R. 
Published: May 2020

Abstract
Background and aims
We aim to quantify the variation in root distribution in a set of 35 experimental wheat lines. We also compared the effect of variation in hydraulic properties of the rhizosphere on water uptake by roots.

Methods
We measured the root length density and soil drying in 35 wheat lines in a field experiment. A 3D numerical model was used to predict soil drying profiles with the different root length distributions and compared with measured soil drying. The model was used to test different scenarios of the hydraulic properties of the rhizosphere.

Results
We showed that wheat lines with no detectable differences in root length density can induce soil drying profiles with statistically significant differences. Our data confirmed that a root length density of at least 1 cm/cm3 is needed to drain all the available water in soil. In surface layers where the root length density was far greater than 1 cm/cm3 water uptake was independent of rooting density due to competition for water. However, in deeper layers where root length density was less than 1 cm/cm3, water uptake by roots was proportional to root density.

Conclusion
In a set of wheat lines with no detectable differences in the root length density we found significant differences in water uptake. This may be because small differences in root density at depth can result in larger differences in water uptake or that the hydraulic properties of the rhizosphere can greatly affect water uptake.
A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics
Authors: Bliziotis Nikolaos G. , Engelke Udo F. H. , Aspers Ruud L. E. G. , Engel Jasper , Deinum Jaap , Timmers Henri J. L. M. , Wevers Ron A. , Kluijtmans Leo A. J. 
Published: May 2020

Abstract
Introduction
When analyzing the human plasma metabolome with Nuclear Magnetic Resonance (NMR) spectroscopy, the Carr–Purcell–Meiboom–Gill (CPMG) experiment is commonly employed for large studies. However, this process can lead to compromised statistical analyses due to residual macromolecule signals. In addition, the utilization of Trimethylsilylpropanoic acid (TSP) as an internal standard often leads to quantification issues, and binning, as a spectral summarization step, can result in features not clearly assignable to metabolites.

Objectives
Our aim was to establish a new complete protocol for large plasma cohorts collected with the purpose of describing the comparative metabolic profile of groups of samples.

Methods
We compared the conventional CPMG approach to a novel procedure that involves diffusion NMR, using the Longitudinal Eddy-Current Delay (LED) experiment, maleic acid (MA) as the quantification reference and peak picking for spectral reduction. This comparison was carried out using the ultrafiltration method as a gold standard in a simple sample classification experiment, with Partial Least Squares–Discriminant Analysis (PLS-DA) and the resulting metabolic signatures for multivariate data analysis. In addition, the quantification capabilities of the method were evaluated.

Results
We found that the LED method applied was able to detect more metabolites than CPMG and suppress macromolecule signals more efficiently. The complete protocol was able to yield PLS-DA models with enhanced classification accuracy as well as a more reliable set of important features than the conventional CPMG approach. Assessment of the quantitative capabilities of the method resulted in good linearity, recovery and agreement with an established amino acid assay for the majority of the metabolites tested. Regarding repeatability, ~ 85% of all peaks had an adequately low coefficient of variation (< 30%) in replicate samples.

Conclusion
Overall, our comparison yielded a high-throughput untargeted plasma NMR protocol for optimized data acquisition and processing that is expected to be a valuable contribution in the field of metabolic biomarker discovery.
On Constituents of the Periodic Layered Microstructure Developed in the Solid-State Reaction Between Zinc and Co2Si
Authors: Wojewoda-Budka J. , Wierzbicka-Miernik A. , Litynska-Dobrzynska L. , Korneva A. , Kodentsov A. 
Published: May 2020

Abstract
The composition and crystal structure of the constituents of the periodic layered microstructure developed during the solid-state reaction between Co2Si intermetallic and zinc at 390 °C were investigated using scanning electron microscopy, transmission electron microscopy, and electron-probe microanalysis. It was demonstrated that the periodic layered morphology generated in the reaction zone of the Co2Si/Zn diffusion couples consists of bands of in situ-formed precipitates of cubic CoSi intermetallic, embedded in a continuous matrix of Co-Zn-based hexagonal phase containing a small amount of silicon. It was suggested that the formation of the hexagonal intermetallic of the same crystal structure as the binary δ phase of the Co-Zn system can be attributed to the possible stabilizing effect of silicon: the δ-phase structure becomes stable in the ternary Co-Si-Zn system at 390 °C.
The Golem of Psychology and the Ecosystemic Epistemology
Authors: Tateo Luca 
Published: May 2020

AbstractThe old controversy about the epistemic status of psychological sciences is useless and sterile. Psychology is ether a hard science nor a soft science. It is an ecological life science, whose object is the whole system of co-developmental relations constituted by the presence of the organism in a given environment. After criticizing the positions of the traditional epistemic debate between hard and soft views of psychology, I propose a way to fundament the core concepts in the method of complementary negation, based on cogenetic logic. Then, I defend the need to develop a third way: an ecological epistemology of psychology.
Computation of effectiveness factor for methanol steam reforming over Cu/ZnO/Al2O3 catalyst pellet
Authors: Olatunde Abayomi O. , Olafadehan Olaosebikan A. , Usman Mohammed A. 
Published: May 2020

AbstractA mathematical model was developed for a diffusion–reaction process in a spherical catalyst pellet contained in a heterogeneous packed bed reactor. The model developed was solved to predict the effectiveness factor and also to perform sensitivity analysis for steam reforming of methanol on Cu/ZnO/Al2O3 catalyst a source of hydrogen fuel. The method of orthogonal collocation was used to solve the resulting differential equation. At temperature below 473 K the effect on intra-particle diffusion limitation is reduced to the minimum indicated by the effectiveness factor being almost equal to one but as the temperature increases above 473 K there is considerable increase in the diffusion limitation effect. The effects of thermal conductivity, diffusion coefficient, catalyst size and surface temperature on effectiveness factor for the reaction process were also considered. Result indicates that catalyst size of $$1.623\,\, \times \,\,10^{ - 4}$$1.623×10-4 m eliminates the effect of intra-particle diffusion resistance in the pellet. The variation of effectiveness factor with Thiele modulus, showing the asymptotic values, using power law and Langmuir–Hinshelwood–Hougen–Watson (LHHW) kinetics, was predicted. The two reaction kinetics had almost the same magnitude of effectiveness factor at different Thiele modulus which indicates that they can adequately predict the reaction process.
Reducing plagiarism through academic misconduct education
Authors: Perkins Mike , Gezgin Ulas Basar , Roe Jasper 
Published: May 2020

AbstractAlthough there is much discussion exploring the potential causes of plagiarism, there is limited research available which provides evidence as to the academic interventions which may help reduce this. This paper discusses a bespoke English for Academic Purposes (EAP) programme introduced at the university level, aimed at improving the academic writing standards of students, reducing plagiarism, and detecting cases of contract cheating. Results from 12 semesters of academic misconduct data (n = 12,937) demonstrate a 37.01% reduction in instances of detected plagiarism following the intervention, but due to limited data, cannot demonstrate a direct impact on reducing detected rates of contract cheating. The results also show a lower than expected proportion of plagiarised assignments (3.46%) among submissions.
THE LONG GOODBYE: PROBLEMATIC POTTERY AND PILGRIMAGE AT CAHAL PECH, BELIZE
Authors: Aimers James J. , Awe Jaime J. 
Published: May 2020

ABSTRACTInvestigations in the site core of Cahal Pech have recovered a range of data reflecting Terminal Classic Maya activity at this Belize Valley site. The materials, which were recovered in a tomb, a burial, and in epicentral plaza deposits, include a diverse assemblage of cultural remains including whole and partial vessels, projectile points, obsidian blade fragments, deer antlers, figurines, pottery flutes, spindle whorls, and jade beads. Similar deposits at other Maya sites in western Belize have been interpreted as evidence forde factorefuse or rapid abandonment. Contextual analyses of the Cahal Pech data suggest that the deposits are more likely associated with post-abandonment activity such as pilgrimage from the still-occupied periphery of the site.