bluuebunny/crossref_metadata_2025_split huggingface dataset:
An estimation of patients at potential risk for drug-induced sexual dysfunction using pharmacy dispensing data
Authors: Gordijn Rineke , Nicolai Melianthe P J , Elzevier Henk W , Guchelaar Henk-Jan , Teichert Martina 
Published: September 2020

Abstract

Background and Objectives
Adverse drug reactions on sexual functioning (sADRs) may seriously decrease a person’s quality of life. A multitude of diseases and drugs are known risk factors for sexual dysfunction. To inform patients better about these potential effects, more insight is needed on the estimated number of patients at high risk for sADRs and their characteristics.

Methods
This cross-sectional study estimated the number of patients in the Netherlands who were dispensed drugs with a potential very high risk (&gt;10%) or high risk (1–10%) for sADRs as registered in the Summary of Product Characteristics, the official drug information text in Europe.

Results
In April 2019, 2.06% of the inhabitants of the Netherlands received drugs with &gt;10% risk for sADRs and 7.76% with 1–10% risk. The majority of these patients had at least one additional risk factor for decreased sexual function such as high age or depression. Almost half of the patients were identified with two or more morbidities influencing sexual functioning. Paroxetine, sertraline and spironolactone were the most dispensed drugs with a potential &gt;10% risk for sADRs. One-third of their first dispenses were not followed by a second dispense, with a higher risk of discontinuation for a decreasing number of morbidities.

Conclusion
About 1 in 11 inhabitants of the Netherlands was dispensed a drug with a potential high risk for sADRs, often with other risk factors for sexual complaints. Further research is needed whether these users actually experience sADRs, to understand its impact on multimorbid patients and to provide alternatives if needed.
Magnetic fabric and archaeomagnetic analyses of anthropogenic ash horizons in a cave sediment succession (Crvena Stijena site, Montenegro)
Authors: Bradák Balázs , Carrancho Ángel , Herrejón Lagunilla Ángela , Villalaín Juan J , Monnier Gilliane F , Tostevin Gilbert , Mallol Carolina , Pajović Goran , Baković Mile , Borovinić Nikola 
Published: September 2020

SUMMARY
An archaeomagnetic, rock magnetic and magnetic fabric study has been carried out on seven anthropogenic ash horizons in the Middle Palaeolithic sedimentary level XXIV at the rock shelter of Crvena Stijena (‘Red Rock’), Montenegro. The study has multiple goals, including the identification of iron bearing minerals formed during combustion, assessment of the suitability of these combustion features for recording the Earth´s magnetic field direction, revelation of the magnetic fabric and its significance in the characterization of cave (rock shelter) burnt facies, and identification of post-burning alteration processes. Magnetite has been identified as the main ferromagnetic component of the ash. The ash layers exhibit a high thermomagnetic reversibility in contrast to the irreversible behaviour of their subjacent burnt black layers which is related to the different temperatures attained. Seven mean archaeomagnetic directions were obtained with acceptable statistical values indicating that these features recorded the field direction at the time of burning. However, some of them are out of the expected range of secular variation for mid-latitude regions suggesting post-burning alterations. The magnetic fabric of the ash was characterized by anisotropy of low field magnetic susceptibility measurements. Statistical analysis (box and whisker plot) of the basic anisotropy parameters, such as foliation, lineation, degree of anisotropy and the shape parameter, along with the alignment of the principal susceptibilities on stereoplots, revealed variation among the ash units. The diverse, oblate to prolate, lineated or strongly foliated, quasi-horizontally and vertically oriented fabrics of the units may indicate different slope processes, such as orientation by gravity, solifluction, run-off water, quasi-vertical migration of groundwater and post-burning/post-depositional alteration of the fabric by rockfall impact. In sum, the magnetic characterization of the ash layers has shown the occurrence of different post-burning alteration processes previously not identified at the site. Alteration processes in prehistoric combustion features are often identified from macroscopic observations but our study demonstrates that multiple processes can affect them and are usually unnoted because they take place on a microscopic scale. Their identification is critical for a correct chronological and cultural interpretation of a site (e.g. collection of samples for dating, stratigraphic displacement of remains), especially if significant alterations are involved. Magnetic methods are therefore a powerful but underutilized tool in palaeolithic research for the identification and evaluation of taphonomic processes affecting prehistoric fires.
Propagation of waves with a wide range of frequencies in digital core samples and dynamic strain anomaly detection: carbonate rock as a case study
Authors: Matsushima Jun , Ali Mohammed Y , Bouchaala Fateh 
Published: September 2020

SUMMARYRecent advancements in various types of seismic measurement methods, such as sonic logging, vertical seismic profiling (VSP) and surface seismic surveys, have allowed the high-quality measurement of seismic wave propagation over a broad frequency range. To elucidate the relationship between seismic wave propagation captured by various seismic methods at widely different frequencies and in highly heterogeneous zones (e.g. fractures, vuggy zones) developed in carbonate reservoirs, laboratory measurements have been conducted over a broad frequency range. However, existing laboratory methods measure the effective properties over an entire core sample. Furthermore, there are few laboratory measurements of individual fracture stiffnesses. We propose a method to indirectly estimate the local properties caused by local anomalies (e.g. fractures) in a core sample over a broad frequency range from the dynamic elastic properties of a dry core sample using synthetic seismic waveforms generated from a digital volume of the core sample. 3-D numerical simulations were conducted over a broad frequency range using a digital core model produced by X-ray computed tomography. The proposed method was applied to numerical models and two types (fractured and vuggy) of carbonate core plugs acquired in an Abu Dhabi oil field, with the frequency ranging from 200 Hz to 100 kHz in the tests. Local strain anomalies and their frequency dependencies were successfully detected in the fractured core plug. Such frequency-dependent local responses could be associated with the micromechanics of incomplete solid–solid contacts at fractures or the heterogeneity of core samples, and thus with the frequency-dependent fracture stiffness. It was also demonstrated that the heterogeneity-induced local strain in a vuggy core plug may affect the accuracy of existing low-frequency laboratory measurements.
Climate change accelerates range expansion of the invasive non-native species, the Pacific oyster,Crassostrea gigas
Authors: King Nathan G , Wilmes Sophie B , Smyth David , Tinker Jonathan , Robins Peter E , Thorpe Jamie , Jones Laurence , Malham Shelagh K 
Published: September 2020

AbstractInvasive non-native species and global warming are two of the greatest components of global ecosystem change. The Pacific oyster, Crassostrea gigas, is the world most cultivated shellfish and was introduced throughout the Northwest European Shelf (NWES) under the premise it could not complete its life cycle. Recent warming trends have changed this and wild populations can be found as far north as Nordic Scandinavia. Under the RCP8.5 concentration pathway, we predict that the majority of NWES coastline will be within C. gigas’s thermal recruitment niche by 2100. Given the widespread occurrence of current naturalized C. gigas populations, its large larval dispersal potential and a lack of feasible management solutions, C. gigas will likely undergo a considerable range expansion this century. The time taken to reach maturity is predicted to decrease by up to 60 days, which may lead to precocious spawning events, facilitating expansion further. Crassostrea gigas can form extensive reefs completely transforming native systems. This may compromise native biodiversity, protected habitats, and commercial species. However, naturalization can also deliver a number of beneficial ecosystem goods and services to human society. Whether naturalization is deemed positive or negative will depend on biogeographic context, the perceptions of stakeholders, and the wider management priorities.
Multidecadal fluctuations of threespine stickleback in the White Sea and their correlation with temperature
Authors: Lajus Dmitry , Ivanova Tatiana , Rybkina Elena , Lajus Julia , Ivanov Mikhail 
Published: September 2020

AbstractA major challenge of contemporary marine science is disentangling consequences of climate change from other impacts, and studying non-target species and using historical resources to see long-term trends can meet this need. However, such data can be fragmented, and here, we demonstrate the potential of leveraging across sources for insight. We assembled a variety of historical sources such as scientific and personal observations, anecdotal information, and archival fisheries data to create an abundance time series on threespine stickleback Gasterosteus aculeatus in the White Sea starting in the late 19th century—the longest time series for this species. Stickleback peaked during the warm period of the 1920–1940s and declined during the colder period of the 1950–1990s and now is the most numerous vertebrate in the sea. Analyses of historical and recent time series based on our own data (2007–2019) showed that stickleback abundance decreases during colder winters. It is not associated with zooplankton biomass, positively correlated with herring Clupea sp. catches and negatively with navaga Eleginus navaga catches. Large population size and food web interactions suggest that change in stickleback abundance has the potential to affect the entire White Sea ecosystem.
Weak and strong error analysis of recursive quantization: a general approach with an application to jump diffusions
Authors: Pagès Gilles , Sagna Abass 
Published: September 2020

Abstract
Observing that the recent developments of spatial discretization schemes based on recursive (product) quantization can be applied to a wide family of discrete time Markov chains, including all standard time discretization schemes of diffusion processes, we establish in this paper a generic strong error bound for such quantized schemes under a Lipschitz propagation assumption. We also establish a marginal weak error estimate that is entirely new to our best knowledge. As an illustration of their generality, we show how to recursively quantize the Euler scheme of a jump diffusion process, including details on the algorithmic aspects grid computation, transition weight computation, etc. Finally, we test the performances of the recursive quantization algorithm by pricing a European put option in a jump Merton model.
Postoperative Imaging Appearance of an Implantable Three-dimensional Bioabsorbable Tissue Marker After Breast Surgery: Initial Experience at a Single Institution
Authors: Chen Christine , Dodelzon Katerina , Ginter Paula S , Drotman Michele B , Arleo Elizabeth K 
Published: September 2020

Abstract

Objective
Three-dimensional bioabsorbable tissue marker (BTM) placement during breast surgery is performed for the purpose of improved surgical cavity delineation for radiotherapy and improved cosmetic outcome. The purpose of this study is to evaluate the postsurgical imaging findings of BTM.

Methods
This Institutional Review Board-approved retrospective review included all patients implanted with BTM at breast surgery from January 2017 to September 2018. Demographics, tumor characteristics, imaging, and histologic findings were evaluated. Medical records were reviewed during a three-year period to evaluate for tumor recurrence.

Results
Ninety-seven patients had BTM implanted, of which 76 patients had imaging follow-up of at least 1 year. Of the 76 patients who had mammographic follow-up, 3 (3.9%) developed suspicious microcalcifications requiring biopsy, yielding ductal carcinoma in-situ in 2 patients and benign calcifications in 1 patient. Of 61 patients who had sonographic follow-up, 44 (72.1%) patients had complex fluid collections containing avascular, heterogeneously hyperechoic solid components, which remained stable or decreased in size over time; no recurrent tumors were found in this group. One patient (1.6%) had a vascular solid mass, which yielded recurrent papilloma. Four (6.6%) patients developed irregular hypoechoic masses at the surgical site, one of which corresponded with a developing asymmetry mammographically; biopsy yielded fibromatosis. Tissue sampling of the remaining three cases yielded invasive ductal carcinoma, fat necrosis, and radiation changes, respectively.

Conclusion
Accurate identification of the expected postoperative imaging appearance of BTM may prevent unnecessary biopsy. Suspicious findings necessitating biopsy are pleomorphic calcifications, developing asymmetry and vascular and irregular hypoechoic masses.
A novel glycine-rich domain protein, GRDP1, functions as a critical feedback regulator for controlling cell death and disease resistance in rice
Authors: Zhao Xiaosheng , Qiu Tiancheng , Feng Huijing , Yin Changfa , Zheng Xunmei , Yang Jun , Peng You-Liang , Zhao Wensheng 
Published: September 2020

Abstract
Lesion mimic mutants constitute a valuable genetic resource for unraveling the signaling pathways and molecular mechanisms governing the programmed cell death and defense responses of plants. Here, we identified a lesion mimic mutant, spl-D, from T-DNA insertion rice lines. The mutant exhibited higher accumulation of H2O2, spontaneous cell death, decreased chlorophyll content, up-regulation of defense-related genes, and enhanced disease resistance. The causative gene, OsGRDP1, encodes a cytosol- and membrane-associated glycine-rich domain protein. OsGRDP1 was expressed constitutively in all of the organs of the wild-type plant, but was up-regulated throughout plant development in the spl-D mutant. Both the overexpression and knockdown (RNAi) of OsGRDP1 resulted in the lesion mimic phenotype. Moreover, the intact-protein level of OsGRDP1 was reduced in the spotted leaves from both overexpression and RNAi plants, suggesting that the disruption of intact OsGRDP1 is responsible for lesion formation. OsGRDP1 interacted with an aspartic proteinase, OsAP25. In the spl-D and overexpression plants, proteinase activity was elevated, and lesion formation was partially suppressed by an aspartic proteinase inhibitor. Taken together, our results reveal that OsGRDP1 is a critical feedback regulator, thus contributing to the elucidation of the mechanism underlying cell death and disease resistance.
Carbon, isotopic ratio 12C/13C, and nitrogen in solar twins: constraints for the chemical evolution of the local disc
Authors: Botelho R B , Milone A de C , Meléndez J , Alves-Brito A , Spina L , Bean J L 
Published: September 2020

ABSTRACT
Abundances of light elements in dwarf stars of different ages are important constraints for stellar yields, Galactic chemical evolution and exoplanet chemical composition studies. We have measured C and N abundances and 12C/13C ratios for a sample of 63 solar twins spanning a wide range in age, based on spectral synthesis of a comprehensive list of CH A-X and CN B-X features using HARPS spectra. The analysis of 55 thin disc solar twins confirms the dependences of [C/Fe] and [N/Fe] on [Fe/H]. [N/Fe] is investigated as a function of [Fe/H] and age for the first time for these stars. Our derived correlation [C/Fe]–age agrees with works for solar-type stars and solar twins, but the [N/Fe]–age correlation does not. The relations [C,N/Fe]–[Fe/H] and [C,N/Fe]–age for the solar twins lay under solar. 12C/13C is found correlated with [Fe/H] and seems to have decreased along the evolution of the local thin disc. Predictions from chemical evolution models for the solar vicinity corroborate the relations [C,N/Fe]–[Fe/H], 12C/13C–age, and [N/O]–[O/H], but do not for the 12C/13C–[Fe/H] and [C/O]–[O/H] relations. The N/O ratio in the Sun is placed at the high end of the homogeneous distribution of solar twins, which suggests uniformity in the N–O budget for the formation of icy planetesimals, watery superearths, and giant planets. C and N had different nucleosynthetic origins along the thin disc evolution, as shown by the relations of [C/N], [C/O], and [N/O] against [O/H] and age. [C/N] and [C/O] are particularly observed increasing in time for solar twins younger than the Sun.
A time-dependent particle acceleration and emission model: understanding particle spectral evolution and blazar flares
Authors: Zheng Y G , Kang S J , Yang C Y , Bai J M 
Published: September 2020

ABSTRACT
The jets of blazars are renowned for their multiwavelength flares and rapid extreme variability; however, there are still some important unanswered questions about the physical processes responsible for these spectral and temporal changes in emission properties. In this article, we develop a time-dependent particle evolution model for the time-varying emission spectrum of blazars. In the model, we introduce time-dependent electric and magnetic fields, which consistently include the variability of relevant physical quantities in the transport equation. The evolution of the electron distribution is solved numerically from a generalized transport equation that contains terms describing the electrostatic, first- and second-order Fermi acceleration, escape of particles due to both advection and spatial diffusion, and also energy losses due to synchrotron emission and inverse-Compton scattering of both synchrotron and external ambient photon fields. We find that the light-curve profiles of blazars are consistent with the particle spectral evolution resulting from time-dependent electric and magnetic fields, rather than the effects of acceleration or cooling processes. The proposed model is able to account simultaneously for the variability of both the energy spectrum and the light-curve profile of the BL Lac object Mrk 421, with reasonable assumptions about the physical parameters. The results indicate strongly that the magnetic field evolution in the dissipated region of a blazar jet can account for the variabilities.
The detection of solid phosphorus and fluorine in the dust from the coma of comet 67P/Churyumov–Gerasimenko
Authors: Gardner Esko , Lehto Harry J , Lehto Kirsi , Fray Nicolas , Bardyn Anaïs , Lönnberg Tuomas , Merouane Sihane , Isnard Robin , Cottin Hervé , Hilchenbach Martin ,   the COSIMA team
Published: September 2020

ABSTRACT
Here, we report the detection of phosphorus and fluorine in solid particles collected from the inner coma of comet 67P/Churyumov–Gerasimenko measured with the COmetary Secondary Ion Mass Analyser (COSIMA) instrument on-board the Rosetta spacecraft, only a few kilometers away from the comet nucleus. We have detected phosphorus-containing minerals from the presented COSIMA mass spectra, and can rule out e.g. apatite minerals as the source of phosphorus. This result completes the detection of life-necessary CHNOPS-elements in solid cometary matter, indicating cometary delivery as a potential source of these elements to the young Earth. Fluorine was also detected with CF+ secondary ions originating from the cometary dust.
Measuring interstellar delays of PSR J0613−0200 over 7 yr, using the Large European Array for Pulsars
Authors: Main R A , Sanidas S A , Antoniadis J , Bassa C , Chen S , Cognard I , Gaikwad M , Hu H , Janssen G H , Karuppusamy R , Kramer M , Lee K J , Liu K , Mall G , McKee J W , Mickaliger M B , Perrodin D , Stappers B W , Tiburzi C , Wucknitz O , Wang L , Zhu W W 
Published: September 2020

ABSTRACT
Using data from the Large European Array for Pulsars, and the Effelsberg telescope, we study the scintillation parameters of the millisecond pulsar PSR J0613−0200 over a 7 yr timespan. The ‘secondary spectrum’ – the 2D power spectrum of scintillation – presents the scattered power as a function of time delay, and contains the relative velocities of the pulsar, observer, and scattering material. We detect a persistent parabolic scintillation arc, suggesting scattering is dominated by a thin, anisotropic region. The scattering is poorly described by a simple exponential tail, with excess power at high delays; we measure significant, detectable scattered power at times out to ${\sim}5 \, \mu {\rm s}$, and measure the bulk scattering delay to be between 50 to 200 ns with particularly strong scattering throughout 2013. These delays are too small to detect a change of the pulse profile shape, yet they would change the times of arrival as measured through pulsar timing. The arc curvature varies annually, and is well fitted by a one-dimensional scattering screen ${\sim}40{{\ \rm per\ cent}}$ of the way towards the pulsar, with a changing orientation during the increased scattering in 2013. Effects of uncorrected scattering will introduce time delays correlated over time in individual pulsars, and may need to be considered in gravitational wave analyses. Pulsar timing programmes would benefit from simultaneously recording in a way that scintillation can be resolved, in order to monitor the variable time delays caused by multipath propagation.
Reverberation of pulsar wind nebulae (I): impact of the medium properties and other parameters upon the extent of the compression
Authors: Bandiera R , Bucciantini N , Martín J , Olmi B , Torres D F 
Published: September 2020

ABSTRACT
The standard approach to the long-term evolution of pulsar wind nebulae (PWNe) is based on one-zone models treating the nebula as a uniform system. In particular for the late phase of evolved systems, many of the generally used prescriptions are based on educated guesses for which a proper assessment lacks. Using an advanced radiative code, we evaluate the systematic impact of various parameters, like the properties of the supernova ejecta, of the inner pulsar, as well of the ambient medium, upon the extent of the reverberation phase of PWNe. We investigate how different prescriptions shift the starting time of the reverberation phase, how this affects the amount of the compression, and how much of this can be ascribable to the radiation processes. Some critical aspects are the description of the reverse shock evolution, the efficiency by which at later times material from the ejecta accretes on to the swept-up shell around the PWN, and finally the density, velocity, and pressure profiles in the surrounding supernova remnant. We have explicitly treated the cases of the Crab Nebula, and of J1834.9−0846, taken to be representatives of the more and the less energetic pulsars, respectively. Especially for the latter object, the prediction of large compression factors is confirmed, even larger in the presence of radiative losses, also confirming our former prediction of periods of superefficiency during the reverberation phase of some PWNe.