bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the Influence of Nondimensionalization on Partial Rank Correlation Coefficient Results when Modeling the Epithelial Mesenchymal Transition
Authors: Gasior Kelsey I. 
Published: December 2024

AbstractPartial Rank Correlation Coefficient (PRCC) is a powerful type of global sensitivity analysis. Usually performed following Latin Hypercube Sampling (LHS), this analysis can highlight the parameters in a mathematical model producing the observed results, a crucial step when using models to understand real-world phenomena and guide future experiments. Recently, Gasior et al. performed LHS and PRCC when modeling the influence of cell–cell contact and TGF-$$\beta $$
β
signaling on the epithelial mesenchymal transition (Gasior et al. in J Theor Biol 546:111160, 2022). Though their analysis provided insight into how these tumor-level factors can impact intracellular signaling during the transition, their results were potentially impacted by nondimensionalizing the model prior to performing sensitivity analysis. This work seeks to understand the true impact of nondimensionalization on sensitivity analysis by performing LHS and PRCC on both the original model that Gasior et al. proposed and seven different nondimensionalizations. Parameter ranges were kept small to capture shifts in the values that originally produced bistable behavior. By comparing these eight different iterations, this work shows that the issues from performing sensitivity analysis following nondimensionalization are two-fold: (1) nondimensionalization can obscure or exclude important parameters from in-depth analysis and (2) how a model is nondimensionalized can, potentially, change analysis results. Ultimately, this work cautions against using nondimensionalization prior to sensitivity analysis if the subsequent results are meant to guide future experiments.
A core–shell microneedle system for stable fibroblast delivery in cell-based therapies
Authors: Medico Federica , Kim Seungcheol , Surwase Sachin S. , Liu Haoyan , Kim Yeu-Chun 
Published: December 2024

AbstractHuman cells, such as fibroblasts and particularly human mesenchymal stem cells (hMSCs), represent a promising and effective therapeutic tool for a range of cell-based therapies used to treat various diseases. The effective delivery of therapeutic cells remains a challenge due to limitations in targeting, invasiveness, and cell viability. To address these challenges, we developed a microneedle (MN) system for minimally invasive cell delivery with high cellular stability. The MN system comprises a core of gelatin methacryloyl (GelMA) hydrogel embedded with fibroblasts, encased in a polylactic-co-glycolic acid (PLGA) shell that enhances structural integrity for efficient skin penetration. The fabrication process involves UV-crosslinking of the GelMA hydrogel with cells, optimizing both cell encapsulation and structural strength. This MN system achieves over 80% cell viability after seven days in vitro, with the conventional GelMA formulation providing superior stability and cellular outcomes. This platform’s ability to ensure sustained cell viability presents promising implications for future applications in regenerative medicine, wound healing, and localized treatments for skin conditions. This MN system opens new avenues for cell-based therapies, offering a versatile and scalable solution for therapeutic cell delivery.
Graphical Abstract
Optimizing machine learning models for wheat yield estimation using a comprehensive UAV dataset
Authors: Khodjaev Shovkat , Bobojonov Ihtiyor , Kuhn Lena , Glauben Thomas 
Published: December 2024

Abstract
Timely and accurate wheat yield forecasts using Unmanned Aircraft Vehicles (UAV) are crucial for crop management decisions, food security, and ensuring the sustainability of agriculture worldwide. While traditional machine learning algorithms have already been used in crop yield modelling, previous research used machine learning algorithms with default parameters and did not take into account the complex, non-linear relationships between model variables. Especially, the combination of vegetation indices, soil properties, solar radiation, and wheat height at the field estimation has not been deeply analysed in scientific literature. We present a machine learning based wheat yield estimation model using comprehensive UAV datasets with the implementation of hyperparameter tuning to improve model performance. The performance of the models before and after optimisations was measured using the metrics RMSE, MAE and R2, and the results showed that the models improved after tuning. Furthermore, we find that the Random Forest (RF) and Extreme Gradient Boosting (XGBoost) models outperformed other examined models. Furthermore, a non-parametric Friedman test with a Nemenyi post-hoc test indicates that the best-performing algorithms for wheat yield estimation and prediction are RF and XGBoost models. In the final step, we utilised a SHapley Additive exPlanations approach to identify the direct impact of each input variable on the yield estimation model. Among the input variables, only the Red-Edge Chlorophyll Index, the Normalised Difference Red-Edge Index and wheat height were found to be of high explanatory power in predicting wheat yield. The optimised model is 7–12% more accurate in estimating wheat yields than traditional linear models.
A biocontrol perspective on mycoviruses in fungal pathogen management
Authors: Galli Matteo , Sede Ana , Heinlein Manfred , Kogel Karl-Heinz 
Published: December 2024

Abstract
Mycoviruses, viruses that infect fungi, have been identified across nearly every fungal taxon. Despite their widespread presence, the ecological effects of mycoviruses remain poorly understood. They can influence the biology of their hosts in various ways, including altering growth, reproduction, and pathogenicity. Their ability to induce either fungal hyper- or hypovirulence and thus regulate general fungal fitness by increasing fungal aggressiveness or, conversely, in extreme cases, converting harmful fungi into beneficial ones, has attracted increasing attention in recent years as a potential means of protecting plants from fungal diseases and pests. Increasing difficulties in controlling fungal diseases, pests and weeds with synthetic chemical pesticides, exacerbated by the emergence of resistance or tolerance to certain active ingredients, and stricter regulatory requirements due to environmental and health concerns, have stimulated interest in alternative approaches. In parallel with the introduction of double-stranded (ds)RNA-based products for crop protection and the fundamental knowledge generated in this field in recent years, the potential use of mycoviruses to control pathogenic fungi appears to be within reach. This review highlights recent advances in the field and emphasizes the potential of mycoviruses as biological control agents (BCAs), with the emphasis on the utilization of mycovirus-induced fungal hypovirulence to control fungi that cause plant diseases and mycovirus-induced fungal hypervirulence to protect plants from fungal hosts such insect pests or weeds.
Editorial zur Special Section „Jüdische und antisemitismuskritische Bildung in Deutschland in (nicht)jüdischer Perspektive“
Authors: Körber Karen , Körs Anna 
Published: December 2024

Zusammenfassung
Die Special Section „Jüdische und antisemitismuskritische Bildung in Deutschland in (nicht)jüdischer Perspektive“ beleuchtet zwei zentrale Entwicklungslinien jüdischer Bildung und die damit verbundenen (nicht)jüdischen Perspektiven: die Wiederkehr jüdischer Schulen als wichtigen Teil jüdisch-pluraler Lebenswelten sowie den Religionsunterricht an staatlichen Schulen als Ort (inter-)religiösen Lernens und antisemitismuspräventiver Bildung. Die ersten drei Beiträge zu jüdischen Schulen konzentrieren sich auf die Wiederkehr jüdischer Bildung nach 1945 und beschäftigen sich mit der Gründung, Verfasstheit und dem Wandel von jüdischen Schulen und Religionsunterricht bis in die Gegenwart und richten damit den Blick auf einen Bereich der Selbstorganisation und -artikulation von Jüdinnen und Juden, dem für den Wiederaufbau und die Formierung eigener Lebenswelten als jüdische Minderheit eine wichtige Bedeutung zukommt. Die folgenden vier Beiträge zum Religionsunterricht an staatlichen Schulen rücken die nichtjüdische Mehrheitsgesellschaft in den Mittelpunkt und wenden sich dem Judentum als Gegenstand des christlichen, islamischen und kooperativen Religionsunterrichts sowie des Fachs Werte und Normen zu, mit dem sich Erwartungen an Wissensvermittlung, Toleranzförderung und Antisemitismusprävention verbinden. Damit präsentiert die Special Section neuere interdisziplinäre Forschungen zu jüdischer und antisemitismuskritischer Bildung in Deutschland als ein auch zukünftig relevantes Forschungsfeld an der Schnittstelle jüdischer Gegenwartsforschung und bildungsbezogener Antisemitismusforschung.
Analysis of a 3D tetrachiral auxetic lattice under compression: Combining experimental and numerical approaches of 4D X-ray microtomography, digital volume correlation, and finite element modeling
Authors: Koudelka Petr , Zlámal Petr , Fíla Tomáš , Souček Kamil , Rada Václav , Neuhäuserová Michaela , Šleichrt Jan , Kytýř Daniel 
Published: December 2024

AbstractWe studied compression of tetrachiral auxetic lattice manufactured using laser powder bed fusion from an aluminum alloy. Using an in-house loading device integrated with an X-ray CT scanner, experiments, including in-situ loading with time-lapse XCT imaging, were performed to obtain 3D images of the lattice to study its geometry, internal structure, and deformation through an in-house digital volume correlation. Numerical analyses based on the voxel model from XCT imaging and the tetrahedral model based on the design geometry were performed. The correlation between the experiment and the simulations was sought by comparing force-displacement diagrams and Poisson’s ratio. Results show that 3D printing of the lattice may lead to significantly different mechanical characteristics. An analysis of the difference between the design geometry and the manufactured lattice, coupled with porosity assessment, was performed to discuss the reasons for the discrepancies between the anticipated deformation response of the lattice and its real behavior.
Linking multi-gene and morphological data in the subclass Scuticociliatia (Protista, Ciliophora) with establishment of the new family Homalogastridae fam. nov.
Authors: Liu Mingjian , Jiang Limin , Zhang Zhe , Wei Fan , Ma Honggang , Chen Zigui , Al-Rasheid Khaled A. S. , Hines Hunter N. , Wang Chundi 
Published: December 2024

Abstract
Scuticociliatia is one of the most species-rich subclasses in the phylum Ciliophora. The evolutionary relationships among Scuticociliatia groups have long been very unclear due to the homogeneity of morphology and insufficiency of molecular data. With morphological and multi-gene-based molecular data presented here, the evolutionary phylogeny of several Scuticociliatia taxa that were hitherto especially poorly defined is analyzed and discussed. The results indicate: (1) all scuticociliates cluster into two well supported and one poorly supported group, representing three order-level taxa; (2) with the support of both morphological and molecular data, a new family Homalogastridae fam. nov. is proposed in the order Philasterida; (3) Parauronema is formally transferred to Uronematidae and Potomacus is treated as incertae sedis in the order Philasterida, therefore Parauronematidae is proposed to be a junior synonym of Uronematidae; (4) the genus Madsenia and the species Parauronema longum and Pseudocyclidium longum are treated as incertae sedis, while the genus Protophyra should be maintained in the family Ancistridae. In addition, the putative secondary structure of internal transcribed spacer 2 (ITS2) of representative taxa from the three orders of Scuticociliatia are analyzed, and consensus structures and nucleotide composition in each order are exhibited.
The correlation between uveal melanoma and iris nevus
Authors: Yang Yuhang , Luo Jingting , Feng Zhaoxun , Li Yang , Wei Wenbin , Liu Yueming 
Published: December 2024

Abstract
Purpose
To investigate the impact of iris nevus on the incidence and prognosis of uveal melanoma (UM).

Methods
A retrospective cohort study was conducted involving 1128 UM cases and 4356 healthy controls. Participants were categorized based on iris nevus presence and grade: grade 0 (no iris nevus), grade 1 (single iris nevus), grade 2 (multiple iris nevi), and grade 3 (partial or complete darkening of the iris). Propensity matching score method was employed to control for age and sex differences, while the χ 2 test was used to compare the existence rate and grade of iris nevus between groups. Univariate ANOVA evaluated differences among various iris nevus grades, the Kaplan–Meier method analyzed the prognosis of patients with different iris nevus grades, and multivariate Cox proportional risk regression analysis was conducted to evaluate the relationship between clinical data and prognosis.

Results
A total of 5484 subjects were analyzed. UM patients exhibited a higher prevalence and grade of iris nevus (all P < 0.001) after propensity matching. Patients with iris nevus in the affected eye did not show a worse prognosis (P = 0.414). However, those with partial or complete iris darkening or multiple nevi had a poorer prognosis compared to those with a single or no iris nevus (all P < 0.05). Iris nevus presence and grade in the healthy eye had no prognostic impact (P = 0.726 and P = 0.825, respectively). The multivariate COX proportional risk model showed that tumor diameter (P < 0.001), age (P = 0.020), and grade of iris nevus in the affected eye (P = 0.009) were independent risk factors for a worse prognosis. LSD analysis revealed that patients with partial or complete darkening of the iris had larger tumor diameters than those without iris nevus (P = 0.013), single nevus (P = 0.015), and multiple nevus (P = 0.023).

Discussion
Our findings indicate a higher proportion and grade of iris nevus in UM patients compared to controls, and a worse prognosis for UM patients with higher-grade iris nevi in the affected eye.
The influence of asset ownership and e-marketing on households’ dietary diversity in rural South Africa
Authors: Ramafoko L. P. , Tsvakirai C. Z. , Tshehla M. 
Published: December 2024

AbstractIntegrating rural populations into formal food markets is widely recognized as a key strategy for enhancing dietary diversity. However, there is limited research on the impact of e-marketing on improving household dietary diversity. This study seeks to fill this gap by evaluating how food retailers’ use of text messaging to communicate food offerings affects dietary diversity. Specifically, the study compares the influence of e-marketing, enabled by mobile phone ownership, with the impact of assets such as financial, human, physical, and agricultural capital. Using a multinomial regression model, data from 166 households in the Moretele Local Municipality in South Africa were analyzed. The results indicate that receiving marketing messages from retailers, as well as asset ownership, positively influenced household dietary diversity. This finding underscores the potential of targeted e-marketing in improving diet quality and suggests that text messaging can be an effective tool for promoting healthier food choices. The study also highlights key assets that development programs should prioritize to help rural communities transition to more nutritious diets.
Quality assessment for large-aperture optical elements inducing phase jumps
Authors: Iancu Vicenţiu , Talpoşi Anda-Maria , Gheorghiu Cristina , Ungureanu Răzvan , Dăncuş Ioan , Matei Dan-Gheorghiţă , Ursescu Daniel 
Published: December 2024

Abstract
Achieving complex pulses with high-power lasers necessitates rigorous testing of specially designed optical components. The qualification of these components using complementary devices to access both the high-resolution and the large-aperture properties, followed by validation using propagation simulations, is proposed here. In particular, the topology of a large-aperture staircase-like Fresnel phase plate used to generate vortex pulses is qualified using a non-contact optical profiler and a large-aperture wavefront measurement setup based on a Shack–Hartmann sensor. The resulting topography is further used for simulating the focus of laser beams after passing through the phase plate. Step height distribution effects on the doughnut-shaped focus are identified, and avoiding the indicated pitfall in the design of the phase plate provides at least a 10-fold reduction of the irradiance modulation on the circumference of the focus in the super-Gaussian case.
The role of olive oil and its constituents in mental health: a scoping review
Authors: Eedy Vanessa , Aucoin Monique 
Published: December 2024

Abstract
Mounting evidence suggests that the Mediterranean diet has a beneficial effect on mental health. It has been hypothesised that this effect is mediated by a variety of foods, nutrients and constituents; however, there is a need for research elucidating which of these components contribute to the therapeutic effect. This scoping review sought to systematically search for and synthesise the research on olive oil and its constituents and their impact on mental health, including the presence or absence of a mental illness or the severity or progression of symptoms. PubMed and OVID MEDLINE databases were searched. The following article types were eligible for inclusion: human experimental and observational studies, animal and preclinical studies. Abstracts were screened in duplicate, and data were extracted using a piloted template. Data were analysed qualitatively to assess trends and gaps for further study. The PubMed and OVID MEDLINE search yielded 544 and 152 results, respectively. After full-text screening, forty-nine studies were eligible for inclusion, including seventeen human experimental, eighteen observational and fourteen animal studies. Of these, thirteen human and four animal studies used olive oil as a comparator. Observational studies reported inconsistent results, specifically five reporting higher rates of mental illness, eight reporting lower and five reporting no association with higher olive oil intake. All human experimental studies and nine of ten animal studies that assess olive oil as an intervention reported an improvement of anxiety or depression symptoms. Olive oil may benefit mental health outcomes. However, more experimental research is needed.
Effects of a six-day, whole-diet sweet taste intervention on pleasantness, desire for and intakes of sweet foods: a randomised controlled trial
Authors: Bielat Aleksandra D. , Rogers Peter J. , Appleton Katherine M. 
Published: December 2024

AbstractReduced exposure to sweet taste has been proposed to reduce sweet food preferences and intakes, but the evidence to support these associations is limited. This randomised controlled trial investigated the effects of a whole-diet sweet taste intervention for 6 d, on subsequent pleasantness, desire for and sweet food intakes. Participants (n 104) were randomised to increase (n 40), decrease (n 43) or make no change to (n 21) their consumption of sweet-tasting foods and beverages for 6 consecutive days. Pleasantness, desire to eat, sweet taste intensity and sweet food and beverage intakes were assessed on days 0 and 7. One hundred and two (98 %) participants completed the study, and self-reported adherence with the dietary interventions was moderate to good (M = 66–72/100 mm), with instructions to decrease sweet food consumption reported as more difficult than the other diets (smallest (t(81) = 2·45, P = 0·02, Mdiff = 14/100 mm, se = 2 mm). In intention-to-treat analyses, participants in the decreased sweet food consumption group reported higher sweet taste intensity perceptions at day 7 compared with day 0 (F(2101) = 4·10, P = 0·02, Mdiff = 6/100 mm, se = 2 mm). No effects were found for pleasantness (F(2101) = 2·04, P = 0·14), desire to eat (F(2101) = 1·49, P = 0·23) or any of the measures of sweet food intake (largest F(2101) = 2·53, P = 0·09). These results were confirmed in regression analyses that took self-reported adherence to the diets into account. Our findings suggest that exposure to sweet taste does not affect pleasantness, desire for or intakes of sweet-tasting foods and beverages. Public health recommendations to limit the consumption of sweet-tasting foods and beverages to reduce sweet food preferences may require revision.
Stakeholder perspectives on the current status and potential barriers of patient involvement in health technology assessment (HTA) across Europe
Authors: Holtorf Anke-Peggy , Bertelsen Neil , Jarke Hannes , Dutarte Maria , Scalabrini Silvia , Strammiello Valentina 
Published: December 2024

Abstract

Background
There are wide variations in the practices of patient involvement in health technology assessment (HTA) in Europe. The field is lacking a consensus on good practices, leading to divergent processes, methods, and evaluation of patient involvement. To identify potential good practice approaches and current gaps, a structured online survey was conducted among HTA stakeholders, including HTA practitioners, patient stakeholders, industry representatives, and others who had experienced patient involvement in HTA.

Methods
The questionnaire was co-created by HTA experts, patient stakeholders, and industry representatives and disseminated between 29 April and 14 September 2022.

Results
Responses (n = 168) were submitted from thirty-two European countries by HTA practitioners (n = 33), patient stakeholders (n = 75), industry stakeholders (n = 42), providers (n = 5), academics (n = 7), and others (n = 6). The responses indicated that “allowing access to treatments that have demonstrated value”is the principle rationale for conducting HTA. In terms of the importance of patient involvement, there was consensus across stakeholder groups that “patients have insights and information [that] no other stakeholder has” and that patient involvement is important “to inform HTA which evidence is most patient-relevant”. Shortcomings were identified in the lack of systematic and transparent processes, an unsatisfactory level of information and guidance, and minimal communication and collaboration.

Conclusions
The diverse stakeholders who responded highlighted the need for improving specific aspects of patient involvement practices, including better guidance and information, a more consistent flow of communication between the HTA body and participating patient stakeholders, and the need to develop and implement a consensus on good practices.
The thrive for a new heritage ethos in Peru?: The Qhapaq Ñan’s policymaking and the ethics of community participation
Authors: Uribe-Chinen Claudia 
Published: December 2024

Abstract
This article examines the Qhapaq Ñan Project in Peru and its unprecedented mobilization of heritage policymaking to foster a participatory approach. The World Heritage listing of the Qhapaq Ñan, or Inca road system, catalyzed a new ethos in the Peruvian cultural heritage sector, reflected in a cohesive set of values and practices centered on community participation. This study analyzes the crafting of a participatory approach within Peruvian national heritage regulations despite legal, technical, and ideological constraints, following the rationales and processes that challenged traditional material-centered paradigms. It focuses on how heritage specialists reimagined their ethical commitments in conceptualizing and implementing this framework. It further demonstrates how participatory practices intersect with official regulations and informal practices within pre-existing technical and normative structures, integrating elements such as benefits, consultation, and collaboration. Therefore, the adoption of the Qhapaq Ñan’s participatory approach is argued not merely as a passive compliance with intergovernmental policy recommendations but as an active assertion of ethical perspectives and practices by heritage specialists.