bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Technique to Assess the Effect of Machining and Subsurface Microstructure on the Fatigue Performance of Ti-6Al-2Sn-4Zr-6Mo
Authors: Suárez-Fernández Daniel , Wynne Bradley P. , Crawforth Pete , Fox Katharine , Jackson Martin 
Published: October 2020

Aerospace titanium components are manufactured under the strictest standards in order to ensure the highest quality. To develop highly efficient machining processes, extensive research and investment is necessary. For the specific case of rotating titanium critical components, large quantities of forged workpieces are machined to determine the effects of the different machining parameters on tool wear characteristics and component structural integrity and performance. However, testing the different permutations of metal removal parameters and tool combinations is expensive and time consuming at the development stage. The novel approach developed and presented here, enables the machining of smaller titanium parts that can be compared 1-to-1 to parts extracted from industrial machined disc components. This approach not only reduces cost, but ultimately accelerates the research and development process due to more rapid feedback between different iterations of the machining parameters.
The proposed technique specifically replicates the face turning operation performed in rotational critical titanium components, such as compressor discs, using small coupons machined in a standard CNC machining centre. The machined coupons can be fatigue tested through a 4-point bending and microstructural analysis can be performed on the tested coupons to directly study the effects of the machining process on the surface and underlying microstructure.
TITANIUM SHEET HOT FORMING IN THE AEROSPACE INDUSTRY
Authors: SANA Guillaume 
Published: October 2020

Technologies dedicated to hot forming of titanium sheet are key processes for the manufacturing of structural and engine parts in the aerospace industry. The evolution of these processes in the past years is strategical taking into account the on-going increase of production rate of commercial aircrafts as single aisle and long-range civil aircrafts.
Starting from the use of single superplastic forming press, the state-of-the art has evolved to the use of automated forming cells from one side and to the development of the Hot Forming process on the other side. These evolutions are pushed by the aerospace market and its needs of a strong and efficient supply chain.
In order to assure production rate, cost saving and part quality to our customer, Aries Alliance offers tailor made solutions adapted to each customer need. From the delivery of fully-automated smart press cell to serial part production Aries Alliance is able to provide smart answer to the challenges brought by end-users. One of the roles of this niche industry is also to promote titanium applications challenged by the market facing strong competition from lightweight alloys like Al‑Li or composite materials especially for aerostructure applications.
Development of α - β type titanium alloy Ti-4.5Al-2.5Cr-1.2Fe-0.1C-0.3Cu-0.3Ni having good forgeability and machinability
Authors: KONNO Takashi , TAMURA Keitaro , ITSUMI Yoshio , YOKOCHI Kohei , AKAZAWA Koichi , OYAMA Hideto , CHODA Takashi 
Published: October 2020

Development of a titanium alloy having excellent hot forgeability and machinability while having the same properties as Ti-64 alloy is effective in reducing the total cost of titanium parts. To develop a new alpha-beta type titanium alloy which has good hot forgeability, machinability and tensile properties equivalent to those of Ti-64 alloy at room temperature, Ti-4.5Al-2.5Cr-1.2Fe-0.1C-nCu-nNi (n=0 to 2) were prepared and evaluated.
The new alloy showed tensile properties equivalent to that of Ti-64 alloy at room temperature. On the other hand, the hot deformation stress of new alloy was about 30% lower than that of Ti-64 alloy, and the excellent deformability was confirmed. The addition of Cu and Ni to Ti-4.5Al-2.5Cr-1.2Fe-0.1C alloy suppressed the amount of wear of tool and improved the machinability. Tool life of new alloy machining is extended by about 1.5 times compared to that of Ti-64 alloy. Addition of Cu and Ni is considered to reduce the reactivity between tool and workpiece and improve machinability.
Applications with semipermeable membranes for humidity recovery in HVAC systems
Authors: Krause Ralph , Rosenbaum Hannes , Herzog Ralf 
Published: October 2020

Both the sensible heat recovery and the combined heat and humidity recovery are state of the art. Of particular importance is the humidity recovery in winter season. The transfer of water vapor from the humidity-laden exhaust air to the very dry fresh air is very important for a good room air quality.
However, all systems established on the market require that supply and exhaust air streams crosses within the device. Practical enthalpy recovery systems for plant concepts with local separation of supply and exhaust air are not available on the market until now.
In order to close this gap, the ILK Dresden works on a R&D project. The objective is the development of a textile heat exchanger, which - integrated into circulatory composite systems - can transmit not only sensible heat but also humidity between spatially separated air streams. The functional principle is based on a liquid sorption process via semipermeable membranes.
The current state of the development will be presented. Furthermore an outlook is given how it is intended to proceed in the project in further steps.
Der Schockraum als Nahtstelle zwischen Präklinik und Klinik
Authors: Bogner-Flatz Viktoria , Hinzmann Dominik , Kanz Karl-Georg , Bernhard Michael 
Published: October 2020

ZusammenfassungDie ständige Vorhaltung und Verfügbarkeit eines Schockraums zur Versorgung von kritisch kranken und schwer verletzten Patienten ist eine wesentliche und für die transsektorale Notfallversorgung wichtige klinische Ressource. In diesem Artikel sollen die derzeitigen Entwicklungen der Schockraumbereitstellung in Deutschland aufgezeigt werden.
Primärprävention des Schlaganfalls
Authors: Gerloff Christian , Diener Hans-Christoph 
Published: October 2020

ZUSAMMENFASSUNGDer Schlaganfall ist eine der Hauptursachen für bleibende Behinderungen. Daher hat die Primärprävention eines ersten Schlaganfalls eine hohe Priorität. Die Primärprävention des ischämischen Schlaganfalls umfasst die Änderung des Lebensstils und der Ernährung, die Behandlung von Risikofaktoren wie Bluthochdruck, Diabetes mellitus und Lipidstörungen, die Thrombozytenaggregationshemmung bei Patienten mit hohem Gefäßrisiko und die Antikoagulation bei Vorhofflimmern (AF). Zu den wichtigsten präventiven Strategien in der Primärprävention von Hirnblutungen gehören die Behandlung von Bluthochdruck, die Reduzierung des Alkoholkonsums und der Verschluss des linken Vorhofohrs bei Patienten mit Vorhofflimmern und dauerhafte Kontraindikationen für eine orale Antikoagulation.
Risk Stratification for the Intensive Care Unit Following Pancreaticoduodenectomy
Authors: Deichmann Steffen , Ballies Uwe , Petrova Ekaterina , Bolm Louisa , Honselmann Kim , Frohneberg Laura , Keck Tobias , Wellner Ulrich Friedrich , Bausch Dirk 
Published: October 2020

Abstract
Introduction In view of the limited capacities in intensive care units and the increasing economic burden, identification of risk factors could allow better and more efficient
planning. Therefore, the aim of this study was to assess independent risk factors for the duration of intensive care unit stay after pancreatoduodenectomy (PD).
Methods 147 patients who underwent pancreatoduodenectomy in the time period from 2013 to 2015 were identified from a prospective database and a retrospective analysis was performed.
The primary endpoint was length of time spent in the ICU. A retrograde analysis was performed using univariate and multivariate regression analysis. All pre-, intra- and postoperative
parameters were considered in the analysis.
Results The median time spent in the intensive care unit (ICU) is one day. The univariate analysis demonstrated increased pack years, cerebrovascular events, anticoagulation,
elevated creatinine and CA 19-9 as preoperative risk factors. In multivariate analysis, antihypertensive medication (AHT; OR 2.46; 95% CI 1.57 – 3.87; p = 0.05), operation time (OR 1.01; 95%
CI 1.00 – 1.01; p = 0.03), extended LAD (OR 5.46; 95% CI 2.77 – 10.75; p = 0.01) and severe PPH (OR 4.01; 95% CI 2.07 – 7.76; p = 0.04) are significant risk factors for longer ICU stay.
Discussion Patients with cardiovascular risk factors and elevated preoperative creatinine level are at greater risk for a prolonged ICU stay. Risk and benefit of an extended LAD
should be weighed during the operation. Median duration on ICU/IMC after PD is one day or less for patients without risk factors. Whether routine monitoring in the ICU/IMC after PD is
necessary must be clarified in further studies.
Therapie der intrazerebralen und subarachnoidalen Blutung
Authors: Huttner Hagen B. , Gerner Stefan T. , Sprügel Maximilian I. 
Published: October 2020

ZUSAMMENFASSUNGIn den letzten Jahren gab es deutliche Fortschritte in der Akutbehandlung von Patienten mit intrazerebraler Blutung (ICB) und Subarachnoidalblutung (SAB). Allerdings sind die Letalität weiterhin hoch und das funktionelle Outcome der Überlebenden oft stark eingeschränkt. Während bei der ICB aufgrund des Parenchymdefekts häufig motorische Einschränkungen im Vordergrund stehen, leiden SAB-Patienten auch an alltagsrelevanten Folgeschäden wie Kopfschmerzen, Depressionen und kognitiven Einschränkungen. Bei der Behandlung der ICB stehen die Vermeidung einer frühen Blutungsprogression durch Blutdruckmanagement und Hämostase im Vordergrund sowie die Erprobung neuerer minimal-invasiver Techniken zur Blutungsausräumung. Weiterhin eine Herausforderung stellt das Management des Perifokalödems, des Hirndrucks, des Ventrikeleinbruchs und Hydrozephalus sowie die langfristige antithrombotische Therapie dar. Bei der SAB steht die zügige Aneurysmaausschaltung und Hydrozephalusbehandlung im Fokus der Akuttherapie. Neue Aspekte haben sich auch bei der Vermeidung und Behandlung von Vasospamen und sekundären zerebralen Ischämien ergeben. Weitere Forschungsfelder sind das optimale Drainagemanagement, mittels Ventrikel- und Lumbaldrainagen, sowie die intraventrikuläre Fibrinolyse. Die vorliegende Übersichtsarbeit geht auf diese relevanten Themenkomplexe in der Akut- und Langzeittherapie von ICB- und SAB-Patienten ein und gibt einen Überblick zu der aktuellen Datenlage und Kontroversen in diesen Behandlungsfeldern.
Insulinpumpe, kontinuierliche und kapilläre Glukosemessung bei Kindern, Jugendlichen und Erwachsenen mit Diabetes mellitus: Daten des DPV-Registers zwischen 1995 und 2019
Authors: Schöttler Hanna , Auzanneau Marie , Best Frank , Braune Katarina , Freff Markus , Heidtmann Bettina , Jung Ralf , Karges Beate , Klee Daniela , Müller Antonia , Schierloh Ulrike , Vogel Christian , Holl Reinhard W. 
Published: October 2020

ZusammenfassungZiel dieser Beobachtungsstudie ist die Beschreibung der aktuellen Nutzung von Diabetestechnologien bei Patienten/-innen mit Diabetes mellitus.Methode Auswertung von Daten des DPV-Registers zur Nutzung der Insulinpumpentherapie (CSII), kontinuierlicher Glukosemessung (CGM) und der Selbstmessung der Blutglukose (SMBG) aus 497 teilnehmenden Zentren in Deutschland, Österreich, Luxemburg und der Schweiz zwischen 1995 und 2019. Die Daten wurden bei Patienten/-innen mit Diabetes Typ 1 (Alter ≥ 0,5 Jahre) für 5 Altersgruppen ausgewertet. Zusätzlich wurden aktuelle (zwischen 2017 und 2019) Geschlechtsunterschiede in der Verwendung von Diabetestechnologie bei Typ-1-Patienten/-innen untersucht, ebenso wie die Nutzung von Insulinpumpen und CGM für Patienten/-innen mit Insulintherapie bei Typ-2-DM, bei zystischer Fibrose (CFRD), bei anderen Pankreaserkrankungen, neonatalem Diabetes und Maturity Onset Diabetes of the Young (MODY).Ergebnisse Es zeigte sich bei Patienten/-innen mit Diabetes Typ 1 ein Anstieg der CSII-Nutzung von 1995 bis 2019 von 1 % auf 55 % (2019: < 6 Jahre: 89 %; 6–< 12 Jahre: 67 %; 12–< 18 Jahre: 52 %; 18–< 25 Jahre: 48 %; ≥ 25 Jahre: 34 %). Die CGM-Nutzung erhöhte sich ab 2016 bis 2019 von 9 % auf 56 % (2019: 67 %; 68 %; 61 %; 47 %; 19 % der jeweiligen Altersgruppe). Die SMBG nahmen von 1995 bis 2015 insbesondere in den jüngeren Altersgruppen zu, gefolgt von einem Rückgang seit dem Jahr 2016 (Alle Patienten: 1995: 3,3/Tag; 2016: 5,4/Tag; 2019: 3,8/Tag). Weibliche Patienten mit Typ-1-Diabetes führten häufiger eine CSII und mehr SMBG als männliche Patienten durch (56 %/48 %, jeweils p-Wert: < 0,0001), während sich bei der CGM-Nutzung keine signifikanten Unterschiede zeigten.Zwischen 2017 und 2019 erfolgte eine Nutzung von Insulinpumpen und CGM bei neonatalem Diabetes (CSII 87 %; CGM 38 %), bei MODY (CSII 14 %; CGM 28 %) und bei CFRD (CSII 18 %; CGM 22 %). CGM und CSII wurden dagegen nur selten von Menschen mit Insulintherapie und Diabetes Typ 2 (CSII < 1 %; CGM 1 %) und bei anderen Pankreaserkrankungen (CSII 3 %; CGM 4 %) genutzt.Schlussfolgerung Moderne Diabetestechnologien werden derzeit insbesondere von pädiatrischen Patienten/-innen mit Diabetes Typ 1, aber auch von Menschen mit neonatalem Diabetes breit genutzt, von Patienten/-innen mit MODY und CFRD sowie Erwachsenen mit Diabetes Typ 1 in etwas geringerem Maße mit ansteigendem Trend. Dagegen sind diese Technologien in der Therapie des Typ-2-Diabetes und bei anderen Pankreaserkrankungen zurzeit nur wenig verbreitet.
Helical Carbenium Ion-Based Organic Photoredox Catalyst: A Versatile and Sustainable Option in Red-Light-Induced Reactions
Authors: Gianetti Thomas , Mei Liangyong 
Published: October 2020

AbstractThe development of a sustainable catalytic system for red-light-induced photocatalysis is presented. The catalytic system consists of a helical carbenium ion-based organic photoredox catalyst (PC) that is capable of using low-energy red light (λmax = 640 nm) for both photooxidations and photoreductions. Its successful applications in the aerobic oxidative hydroxylation of arylboronic acids and in the oxidation of benzylic C(sp3)–H bonds (reductive quenching), as well as in dual transition-metal/organocatalyzed C–H arylations and intermolecular atom-transfer radical additions (oxidative quenching) provide further support for its role as a versatile and efficient organic PC.1	Introduction2	Red-Light-Induced Photocatalysis3	Properties of N,N′-Dipropyl-1,13-dimethoxyquinacridinium Tetrafluoroborate4	Two Proposed Representative Catalytic Cycles of [
n
Pr-DMQA+][BF4
–]5	Applications of [
n
Pr-DMQA+][BF4
–] in Red-Light-Induced Photocatalysis6	Conclusion
Synthesis of Fused Pyrimido[1,6-a]indolones via Rhodium(III)-Catalyzed Cascade Annulations
Authors: Raji Reddy Chada , Bodasu Srinivas , Mallesh Kathe , Prapurna Y. Lakshmi 
Published: October 2020

AbstractA novel method for the synthesis of fused pyrimido[1,6-a]-indolone derivatives by annulation of 2-alkynylaryl aldehydes/2-alkynyl­arylidene ketones with N-(pivaloyloxy)-1H-indole-1-carboxamide catalyzed by rhodium has been accomplished. The reaction proceeds through C–H activation based annulation with alkyne moiety followed by addition of nitrogen on to aldehyde/activated alkene to give the products in moderate to good yields. Highly fluorescent dipyrrinone analogues could be synthesized from the derived products.
Inter- and Intramolecular [2+2+2] Cycloaddition of Alkyne Triple Bonds to the Carbonyl Function of Aldehydes and Ketones Enabled by η5-Cyclopentadienylcobalt(L)(L′)
Authors: Vollhardt K. Peter C. , Colovray-Gotteland Véronique , Harvey Daniel F. , Johnson Barry M. , Ung Christopher S. 
Published: October 2020

Abstract1,7-Octadiyne underwent [2+2+2] cycloaddition to acetone in the presence of η5-cyclopentadienylcobalt(L)(L′) complexes to give (η5-cyclopentadienyl)[(1,4,4a,8a-η4)-5,6,7,8-tetrahydro-3,3-dimethyl-3H-2-benzopyran]cobalt, in which the two triple bonds and the carbonyl moiety have combined to engender a 2H-pyran ring complexed to CpCo. The scope of this reaction was explored, including cocyclizations of ynals and ynones with bis(trimethylsilyl)acetylene, as well as all-intramolecular reorganizations of α,ω-diynals and -diynones. Two major trajectories were observed in the case of aldehydes, the (often minor) [2+2+2] pathway and a competing trail featuring a formal 1,5-hydride shift that results in CpCo–dienones. The latter is obviated for ketone substrates. Preliminary chemistry of selected complexes uncovered unprecedented reactions, such as acid-catalyzed ring openings and additions of amines, the latter providing access to novel carbon frames.
Utilization of Borane-Catalyzed Hydrosilylation as a Dearomatizing Tool: Six-Membered Cyclic Amidine Synthesis from Isoquinolines and Pyridines
Authors: Cao Vinh Do , Jo Dong Geun , Joung Seewon , Kim Huiae , Kim Changeun , Yun Seula 
Published: October 2020

AbstractIn this study, a convenient strategy to synthesize six-membered­ cyclic amidines from isoquinolines and pyridines has been developed. Borane-catalyzed hydrosilylation of each N-heteroarene was utilized as a dearomatizing tool. Substrate scope is broad with respect to both isoquinolines and pyridines, with various reaction pathways depending on the substitution pattern of the N-heteroarenes. The reaction mechanism and reactivity of each class of N-heteroarenes has been discussed. The resulting six-membered (Z)-sulfonyl amidine products are rarely reported and are mostly unprecedented. The scalability of this method and versatility of the cyclic amidine products are also presented.
Association between DNA Damage and Serum Levels of Copper, Zinc, and Selenium in Full-Term Neonates with Late-Onset Sepsis
Authors: Wahby Aliaa Ahmed , Elwassif Maha , Magdy Mai , Hamid Tamer A. Abdel , Ibrahim Alshaymaa A. 
Published: October 2020

Abstract
Objective The alteration in certain trace elements is usually associated with impaired immune function and higher oxidative stress. Therefore, these elements are suggested to play an important role in the pathogenesis of neonatal sepsis. We aimed to evaluate copper (Cu), zinc (Zn), and selenium (Se) serum levels in full-term neonates with late-onset sepsis (LOS) and correlate these levels with DNA damage and other risk factors of sepsis.
Methods The study included a group of 100 neonates diagnosed with sepsis serving as the case group and another one of 60 neonates serving as the control group. DNA damage was assessed using the comet assay method and trace elements were measured using inductively coupled plasma mass spectrometry.
Results Compared with controls, the percentage of DNA damage was significantly elevated in patients with sepsis, while serum levels of Cu, Zn, and Se were markedly decreased (p = 0.001). A strong negative correlation was revealed between Se and DNA damage (r = −0.6, p = 0.001). However, no correlations were found between Cu or Zn and DNA damage. Univariate logistic regression analysis revealed that DNA damage as well as Cu, Zn, and Se serum levels can be considered as relevant risk factors for neonatal sepsis (p = 0.008, 0.004, 0.004, and 0.003, respectively). Receiver-operating characteristic curve analysis showed that the strongest indicator for neonatal sepsis was Se (area under the curve [AUC] = 0.94, confidence interval [CI] = 0.9–0.98, p = 0.001), followed by Cu (AUC = 0.9, CI = 0.85–0.96, p = 0.001), and then Zn (AUC = 0.87, CI = 0.8–0.93, p = 0.001).
Conclusion The percentage of DNA damage may help in the assessment of neonatal sepsis severity. Altered levels of Cu, Zn, and Se may play significant role in the pathogenesis of neonatal sepsis. Se serum level is strongly correlated with percentage of DNA damage. Therefore, Se can predict the severity of LOS.
Clinicians’ narratives in the era of evidence-based practice
Authors: Lazzaro-Salazar Mariana 
Published: October 2020

Abstract
In evidence-based practices, narratives are the vehicle through which medical knowledge is shared and clinical
judgment is grounded. This paper explores narratives as a sanctioned social practice that help a group of clinicians in a
healthcare institution in New Zealand build and negotiate expertise and accountability, as they discuss clinical cases. To this
end, the paper investigates narratives in six staff meetings, which were video and audio recorded. The paper presents a discursive
analysis of the functions of narratives in this context to show how narratives are interactional achievements that are pivotal to
clinical decision-making and to building and contesting professional stances. Finally, the paper reflects on the value of
narratives as shared resources that are sometimes revisited and reframed over time and that help construct a common thread of
history that becomes part of the cultural capital of the organization and positions clinicians as core members of their
community.
Doing narrative analysis from a narratives-as-practices perspective
Authors: De Fina Anna 
Published: October 2020

Abstract
In this paper I lay out some of the main theoretical methodological principles that underlie a
narratives-as-practices approach and discuss three foci that emerge from current research and pave the way for future
investigations. In particular, I focus on mobility, connectivity, time/space anchoring and chronotopicity as both characteristics
of narrative and research areas which allow for an integration of the focus of interactional approaches on emergence with a
consideration of the historical and social embedding of narratives into practices. I review recent research that has contributed
to this trend in narrative studies and discuss some of the limitations of current work and areas that need further investigation.
I advocate for an expansion of research on a wider variety of practices, attention to the characteristics of narrative genres, and
in general a stronger critical engagement with ways in which narratives participate in social processes involving power and
inequality.
Online methods in research on input processing and processing instruction
Authors: Keating Gregory D. 
Published: October 2020

Abstract
Evidence for the input processing (IP) model (VanPatten, 1996, 2004, 2007, 2015a, 2020) and the benefits of processing instruction (PI) comes largely from offline tasks, despite the fact that both are concerned with online sentence comprehension. This chapter aims to stimulate more online research in these areas. I first provide a brief summary of techniques that measure real-time sentence comprehension and then offer suggestions for how they can be used in research on the IP model and PI. Lastly, I review recent online studies of the effects of PI on second language (L2) learners’ real-time sentence comprehension. I end by proposing two new hypotheses regarding the potential that PI has to benefit L2 learners’ online processing of input.