bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational modelling suggests that Barrett’s oesophagus may be the precursor of all oesophageal adenocarcinomas
Authors: Curtius Kit , Rubenstein Joel H , Chak Amitabh , Inadomi John M 
Published: November 2020

ObjectiveBarrett’s oesophagus (BE) is a known precursor to oesophageal adenocarcinoma (OAC) but current clinical data have not been consolidated to address whether BE is the origin of all incident OAC, which would reinforce evidence for BE screening efforts. We aimed to answer whether all expected prevalent BE, diagnosed and undiagnosed, could account for all incident OACs in the US cancer registry data.DesignWe used a multiscale computational model of OAC that includes the evolutionary process from normal oesophagus through BE in individuals from the US population. The model was previously calibrated to fit Surveillance, Epidemiology and End Results cancer incidence curves. Here, we also utilised age-specific and sex-specific US census data for numbers at-risk. The primary outcome for model validation was the expected number of OAC cases for a given calendar year. Secondary outcomes included the comparisons of resulting model-predicted prevalence of BE and BE-to-OAC progression to the observed prevalence and progression rates.ResultsThe model estimated the total number of OAC cases from BE in 2010 was 9970 (95% CI: 9140 to 11 980), which recapitulates nearly all OAC cases from population data. The model simultaneously predicted 8%–9% BE prevalence in high-risk males age 45–55, and 0.1%–0.2% non-dysplastic BE-to-OAC annual progression in males, consistent with clinical studies.ConclusionThere are likely few additional OAC cases arising in the US population outside those expected from individuals with BE. Effective screening of high-risk patients could capture the majority of population destined for OAC progression and potentially decrease mortality through early detection and curative removal of small (pre)cancers during surveillance.
Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin, iron, transferrin, vitamin B12and folate tests
Authors: Furundarena J R , Uranga Alasne , González Carmen , Martínez Bruno , Iriondo June , Ondarra Laida , Arambarri Amaia , San Vicente Ricardo , Sarasqueta Cristina , Lombardi Clara , Altuna Ane , Rois Nicolas 
Published: November 2020

AimTo evaluate the influence of an algorithm designed to incorporate reflex testing according to haemogram results for analytical tests ordered to investigate anaemia.MethodsIn 2020, a new request for ‘initial study of anaemia’ was created in three primary care pilot centres for suspected anaemia or new anaemias. A haemogram was ordered and the remainder of the tests were created in a reflex manner according to an algorithm integrated in the laboratory information system that also generates a comment that is completed and validated by a haematologist. The demand for tests was evaluated over three time periods.ResultsOf 396 requests, anaemia was detected in 80 (20.2%), with 26 microcytic anaemias (6.57%), 20 iron deficiency anaemias, 41 (10.3%) normocytic anaemias and 13 macrocytic anaemias (3.28%); 4 with folate deficiency; and 1 haemolytic anaemia. No haematological diseases were detected. Twenty-four (6.06%) cases exhibited microcytosis/hypochromia without anaemia, 12 of which exhibited iron deficiency. Four young women exhibiting within-limit haemoglobin levels had iron deficiency. There were 56 (14.1%) cases of macrocytosis without anaemia.With the new profile of ‘initial study of anaemia’, the demand for tests was reduced and was significantly lower than in the remainder of primary centres for iron, transferrin, ferritin, vitamin B12and folate.ConclusionsA new profile of ‘initial study of anaemia’ in the request form with algorithms integrated in the laboratory information system enabled submission of orders and decreased the demand for unnecessary iron, transferrin, ferritin, vitamin B12and folate tests.
Clinicopathological characteristics and management of colitis with anti-PD1 immunotherapy alone or in combination with ipilimumab
Authors: Nahar Kazi J , Rawson Robert V , Ahmed Tasnia , Tattersall Stephen , Sandanayake Neomal , Kiely Christopher J , Lo Serigne , Carlino Matteo , Palendira Umaimainthan , Scolyer Richard A , Long Georgina V , Menzies Alexander M 
Published: November 2020

BackgroundColitis is one of the common immune-related adverse events that leads to morbidity and treatment discontinuation of immunotherapy. The clinical presentation, endoscopic and histopathological features and best management of this toxicity are not well defined.Patients and methodsPatients with metastatic melanoma who received immunotherapy (programmed cell death protein 1 (PD1) antibodies, alone or in combination with a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody (PD1 +CTLA-4)) and who developed clinically significant colitis (requiring systemic corticosteroids) were identified retrospectively from two academic centers. Clinical data were collected for all patients; endoscopic and histopathological data were examined in a subset.ResultsFrom May 2013 to May 2019, 118/1507 (7.8%) patients developed significant colitis; 80/553 (14.5%) after PD1+CTLA-4, 35/1000 (3.5%) PD1 alone, and three patients after Ipilimumab (IPI) alone. Combination therapy-induced colitis was more frequent (14.5% vs 3.5% in PD1 alone, p=<0.0001), had an earlier onset (6.3 weeks vs 25.7 weeks, p=<0.001), was more severe (grade 3/4 69% vs 31%, p=<0.001), and are more likely to require higher doses of steroids (91% vs 74%, p=0.01) than PD1 colitis. Among all patients treated with steroids (N=114), 54 (47%) responded and required no further therapy (steroid sensitive), 47 patients (41%) responded to infliximab (infliximab sensitive), and 13 (11%) were infliximab refractory and needed further immunosuppressive drugs. Infliximab-refractory patients all had onset within 4 weeks of immunotherapy commencement and were more likely to have an underlying autoimmune disease, have higher grade colitis, and require longer immunosuppression, yet had similar response and survival than other patients with colitis. Of 43 (37%) patients re-resumed treatment with PD1 monotherapy after colitis resolution, 16 (37%) of whom developed recurrent colitis. Endoscopic and histopathologic data were available for 64 patients. Most had left-sided colitis, with an increase in chronic inflammatory cells and neutrophils within the lamina propria, an increase in neutrophils in the surface epithelium, without increased lymphocytes or increased eosinophils. Infliximab-refractory colitis had a trend towards more confluent pancolitis with edema, erythema, ulceration, and absent vascularity with neutrophilic infiltration and erosion.ConclusionClinically significant colitis varies in presentation, response to immunosuppression, and endoscopic/histologic features depending on the immunotherapy type. Infliximab-refractory colitis occurs early, is often high grade, and has adverse endoscopic and histopathologic features
Clinical profile and prognostic factors of alcoholic cardiomyopathy in tribal and non-tribal population
Authors: Dungdung Ajit , Kumar Abhinav , Guria Rishi Tuhin , Preetam Mukul , Tara Ruth K , Kumar Bindey , Saba Mohammad Kamal 
Published: November 2020

ObjectiveAlcoholic cardiomyopathy (ACM) is a leading cause of non-ischaemic dilated cardiomyopathy (DCM) in tribal and non-tribal population. However, no study has been done depicting the correlation between clinical profile and prognosis of ACM in tribal and non-tribal population. This study also defines the long-term outcome and prognostic markers of ACM.MethodsWe studied 290 patients with ACM who were evaluated in our institute between January 2013 and December 2016. The primary endpoint of the study was all-cause mortality. Statistical analysis was done by using Kaplan-Meier survival curves for the assessment of all-cause mortality and Cox regression for the assessment of risk factors.ResultsAfter a median follow-up period of 3.75 years (IQR: 3–4 years), 50 patients with ACM (37.3%) died among tribal population while 14 patients (9%) died among non-tribal population. Independent predictors of all-cause mortality in ACM identified by Cox regression were left ventricular ejection fraction (LVEF) (HR: 0.883; 95% CI 0.783 to 0.996; p=0.043), QRS duration (HR: 1.010; 95% CI 1.007 to 1.017; p=0.005) and Child-Turcotte-Pugh (CTP) Scoring (HR: 12.332; 95% CI 6.999 to 21.728; p<0.001) at admission. The Kaplan-Meier survival probability estimate was 95.1% at 1 year and all-cause mortality was found to be higher in patients with QRS>120 ms, LVEF ≤35%, CTP Grade B/C than patients with QRS≤120 ms, LVEF >35% and CTP Score A, respectively (log-rank χ²=55.088, p<0.001; log-rank χ²=32.953, p<0.001; log-rank χ²=139.764, p<0.001, respectively).ConclusionOur study indicated increased morbidity and mortality in tribal population. LVEF, QRS duration and CTP Scoring at the time of presentation were found to be the independent prognostic markers of patients with ACM.
Symptoms, risk factors, diagnosis and treatment of urinary tract infections
Authors: Kaur Rajanbir , Kaur Rajinder 
Published: November 2020

ABSTRACTUrinary tract infection (UTI) is a common microbial infection found in all ages and sexes which involves inflammation of the urinary tract. These infections can range from simple bladder inflammation, that is, cystitis, to severe cases of uroseptic shock. UTI ranks as the number 1 infection that leads to a prescription of antibiotics after a doctor’s visit. These infections are sometimes distressing and even life threatening, and both males (12%) and females (40%) have at least one symptomatic UTI throughout their lives. Diagnostic failures in case of bacterial infections are the main contributing factor in improper use of antibiotics, delay in treatment and low survival rate in septic conditions. So, early diagnosis and appropriate therapy with antibiotics are the most significant requirements for preventing complicated UTI conditions such as urosepsis. This review article summarises the symptoms of the UTIs and the associated risk factors to it. The various conventional and recent diagnostic methods were also discussed in this review, along with treatment therapies with or without antibiotics.
iQOS: evidence of pyrolysis and release of a toxicant from plastic
Authors: Davis Barbara , Williams Monique , Talbot Prue 
Published: November 2020

ObjectiveTo evaluate performance of the I quit original smoking (iQOS) heat-not-burn system as a function of cleaning and puffing topography, investigate the validity of manufacturer’s claims that this device does not burn tobacco and determine if the polymer-film filter is potentially harmful.MethodsiQOS performance was evaluated using five running conditions incorporating two different cleaning protocols. Heatsticks were visually and stereomicroscopically inspected preuse and postuse to determine the extent of tobacco plug charring (from pyrolysis) and polymer-film filter melting, and to elucidate the effects of cleaning on charring. Gas chromatography–mass spectrometry headspace analysis was conducted on unused polymer-film filters to determine if potentially toxic chemicals are emitted from the filter during heating.ResultsFor all testing protocols, pressure drop decreased as puff number increased. Changes in testing protocols did not affect aerosol density. Charring due to pyrolysis (a form of organic matter thermochemical decomposition) was observed in the tobacco plug after use. When the manufacturer’s cleaning instructions were followed, both charring of the tobacco plug and melting of the polymer-film filter increased. Headspace analysis of the polymer-film filter revealed the release of formaldehyde cyanohydrin at 90°C, which is well below the maximum temperature reached during normal usage.DiscussionDevice usage limitations may contribute to decreases in interpuff intervals, potentially increasing user’s intake of nicotine and other harmful chemicals. This study found that the tobacco plug does char and that charring increases when the device is not cleaned between heatsticks. Release of formaldehyde cyanohydrin is a concern as it is highly toxic at very low concentrations.
Electromagnetic transition form factors, E2/M1 and C2/M1 ratios of the baryon decuplet
Authors: Kim June-Young , Kim Hyun-Chul 
Published: November 2020

AbstractWe investigate the electromagnetic transition form factors of the baryon decuplet to the baryon octet, based on the self-consistent SU(3) chiral quark-soliton model, taking into account the effects of explicit breaking of flavor SU(3) symmetry. We emphasize the $$Q^2$$

Q
2

dependence of the electromagnetic $$N\rightarrow \Delta $$

N
→
Δ

transition form factors and the ratios of E2/M1 and C2/M1 in comparison with the experimental and empirical data. In order to compare the present results of the electromagnetic transition form factors of the $$N\rightarrow \Delta $$

N
→
Δ

with those from lattice QCD, we evaluate the form factors with the pion mass deviated from its physical value. The results of the E2/M1 and C2/M1 ratios are in good agreement with the lattice data. We also present the results of the electromagnetic transition form factors for the decuplet to the octet transitions.
Effect of Internal Knowledge Sourcing on MNEs Subsidiaries’ Service Innovation Performance. The Role of Exploitative Learning and Entrepreneurial Orientation
Authors: Otoo Charles Oduro Acheampong , Li Wenyuan , Pomegbe Wisdom Wise Kwabla , Bamfo Bylon Abeeku , Dogbe Courage Simon Kofi 
Published: November 2020

This study assessed the influence of internal knowledge sourcing on MNEs subsidiaries’ service innovation performance. It also considered the moderating role of entrepreneurial orientation, as well as the mediating role of exploitative learning. Empirical analysis was based on primary data gathered from 156 MNE subsidiaries. Various validity and reliability checks were conducted before the presentation of the actual analysis, which was conducted using Ordinary Least Squares approach, run using SPSS (v. 20). Findings indicate that, exploitative learning partially mediates the relationship between internal knowledge sourcing and MNE subsidiaries’ service innovation performance. Entrepreneurial orientation however, dampens the positive relationship between internal knowledge sourcing and exploitative learning. This study adds to the existing debate in the arena of knowledge-based view of the firm.
Fabrication of In2O3-SnS2 Core–Shell Heterojunction for Efficient Photocatalytic Removal of Hexavalent Chromium
Authors: Lei Ze-Xiao , Yang Feng-Yi , Yuan Cong , Tai Lang , Yao Chang-Yu , Fang Dong 
Published: November 2020

The development of heterojunction composites with core–shell structure could effectively facilitate the separation of carriers. In this work, a novel In2O3-SnS2 (IOS) core–shell heterojunction photocatalyst was successfully synthesized for the efficient photocatalytic reduction of hexavalent chromium (Cr(VI)), namely, the In2O3 nanorods were obtained through successive hydrothermal and carbonization process using urea and glucose as template. Then, SnS2 nanosheets were successfully in situ coated onto In2O3 nanorods. The spectroscopic characterization and photo-electrochemistry test indicated that the IOS core–shell heterojunction could effectively accelerate the separation and transport of carriers and suppress the recombination of carriers. The photocatalytic performance of IOS was evaluated by photocatalytic reduction Cr(VI). The results showed that IOS-4 samples almost completely removed Cr(VI) (20 mg/L), within 90 min under visible light, which was superior to pure In2O3 and SnS2. Furthermore, IOS samples also possess excellent stability, the removal efficiency was still maintained at 90% after five cycles. This work provided a reliable method for designing core–shell heterojunctions for the photocatalytic removal of Cr(VI) under visible light.
Enhanced electrical conductivity in Zr-Doped (La0.7Ba0.3)(Mn0.5Fe0.5)O3 solid solutions
Authors: Kumar Yogesh , Pal Jaswinder , Malhi Parambir Singh , Kumar Rakesh 
Published: November 2020

The perovskite ([Formula: see text][Formula: see text]([Formula: see text][Formula: see text][Formula: see text]O3, where [Formula: see text] = 0.1, 0.2 and 0.3, ceramics were synthesized by solid-state reaction method. The introductory structural studies were followed through by X-ray diffraction technique and the results have disclosed that all the samples were crystallized into an isolated phase. The Zr substitution in the resulting solid solutions increases the electrical conductivity and the maximum value of ac conductivity has been found to be [Formula: see text]118.8 S [Formula: see text] cm[Formula: see text] for [Formula: see text] = 0.3 at 200[Formula: see text]C (at 1 MHz). The frequency dependence of ac conductivity data follows Jonscher’s power law. The variation of the exponent [Formula: see text] versus temperature follows the nonoverlapping small polaron tunneling (NSPT) model. The dielectric relaxation has been observed to be of non-Debye nature for all measuring temperatures (50–200[Formula: see text]C). The impedance spectroscopy reveals that all the samples exhibit negative temperature coefficient of resistance (NTCR) behavior. The prepared samples (for [Formula: see text] > 1) are supposed to be suitable for cathode materials in SOFCs.
Handling bidirectional control flow
Authors: Zhang Yizhou , Salvaneschi Guido , Myers Andrew C. 
Published: November 2020

Pressed by the difficulty of writing asynchronous, event-driven code, mainstream languages have recently been building in support for a variety of advanced control-flow features. Meanwhile, experimental language designs have suggested effect handlers as a unifying solution to programmer-defined control effects, subsuming exceptions, generators, and async–await. However, despite these trends, complex control flow—in particular, control flow that exhibits a bidirectional pattern—remains challenging to manage.
We introduce bidirectional algebraic effects, a new programming abstraction that supports bidirectional control transfer in a more natural way. Handlers of bidirectional effects can raise further effects to transfer control back to the site where the initiating effect was raised, and can use themselves to handle their own effects. We present applications of this expressive power, which falls out naturally as we push toward the unification of effectful programming with object-oriented programming. We pin down the mechanism and the unification formally using a core language that makes generalizations to effect operations and effect handlers.
The usual propagation semantics of control effects such as exceptions conflicts with modular reasoning in the presence of effect polymorphism—it breaks parametricity. Bidirectionality exacerbates the problem. Hence, we set out to show the core language, which builds on the existing tunneling semantics for algebraic effects, is not only type-safe (no effects go unhandled), but also abstraction-safe (no effects are accidentally handled). We devise a step-indexed logical-relations model, and construct its parametricity and soundness proofs. These core results are fully mechanized in Coq. While a full-featured compiler is left to future work, experiments show that as a first-class language feature, bidirectional handlers can be implemented efficiently.
Formulog: Datalog for SMT-based static analysis
Authors: Bembenek Aaron , Greenberg Michael , Chong Stephen 
Published: November 2020

Satisfiability modulo theories (SMT) solving has become a critical part of many static analyses, including symbolic execution, refinement type checking, and model checking. We propose Formulog, a domain-specific language that makes it possible to write a range of SMT-based static analyses in a way that is both close to their formal specifications and amenable to high-level optimizations and efficient evaluation.
Formulog extends the logic programming language Datalog with a first-order functional language and mechanisms for representing and reasoning about SMT formulas; a novel type system supports the construction of expressive formulas, while ensuring that neither normal evaluation nor SMT solving goes wrong. Our case studies demonstrate that a range of SMT-based analyses can naturally and concisely be encoded in Formulog, and that — thanks to this encoding — high-level Datalog-style optimizations can be automatically and advantageously applied to these analyses.
A model for detecting faults in build specifications
Authors: Sotiropoulos Thodoris , Chaliasos Stefanos , Mitropoulos Dimitris , Spinellis Diomidis 
Published: November 2020

Incremental and parallel builds are crucial features of modern build systems. Parallelism enables fast builds by running independent tasks simultaneously, while incrementality saves time and computing resources by processing the build operations that were affected by a particular code change. Writing build definitions that lead to error-free incremental and parallel builds is a challenging task. This is mainly because developers are often unable to predict the effects of build operations on the file system and how different build operations interact with each other. Faulty build scripts may seriously degrade the reliability of automated builds, as they cause build failures, and non-deterministic and incorrect outputs.
To reason about arbitrary build executions, we present BuildFS, a generally-applicable model that takes into account the specification (as declared in build scripts) and the actual behavior (low-level file system operation) of build operations. We then formally define different types of faults related to incremental and parallel builds in terms of the conditions under which a file system operation violates the specification of a build operation. Our testing approach, which relies on the proposed model, analyzes the execution of single full build, translates it into BuildFS, and uncovers faults by checking for corresponding violations.
We evaluate the effectiveness, efficiency, and applicability of our approach by examining 612 Make and Gradle projects. Notably, thanks to our treatment of build executions, our method is the first to handle JVM-oriented build systems. The results indicate that our approach is (1) able to uncover several important issues (247 issues found in 47 open-source projects have been confirmed and fixed by the upstream developers), and (2) much faster than a state-of-the-art tool for Make builds (the median and average speedup is 39X and 74X respectively).
Shiftry: RNN inference in 2KB of RAM
Authors: Kumar Aayan , Seshadri Vivek , Sharma Rahul 
Published: November 2020

Traditionally, IoT devices send collected sensor data to an intelligent cloud where machine learning (ML) inference happens. However, this course is rapidly changing and there is a recent trend to run ML on the edge IoT devices themselves. An intelligent edge is attractive because it saves network round trip (efficiency) and keeps user data at the source (privacy). However, the IoT devices are much more resource constrained than the cloud, which makes running ML on them challenging. Specifically, consider Arduino Uno, a commonly used board, that has 2KB of RAM and 32KB of read-only Flash memory. Although recent breakthroughs in ML have created novel recurrent neural network (RNN) models that provide good accuracy with KB-sized models, deploying them on tiny devices with such hard memory requirements has remained elusive.
We provide, Shiftry, an automatic compiler from high-level floating-point ML models to fixed-point C-programs with 8-bit and 16-bit integers, which have significantly lower memory requirements. For this conversion, Shiftry uses a data-driven float-to-fixed procedure and a RAM management mechanism. These techniques enable us to provide first empirical evaluation of RNNs running on tiny edge devices. On simpler ML models that prior work could handle, Shiftry-generated code has lower latency and higher accuracy.