bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-vendor, multi-center study on reproducibility and comparability of fast strain-encoded cardiovascular magnetic resonance imaging
Authors: Erley Jennifer , Zieschang Victoria , Lapinskas Tomas , Demir Aylin , Wiesemann Stephanie , Haass Markus , Osman Nael F , Simonetti Orlando P , Liu Yingmin , Patel Amit R , Mor-Avi Victor , Unal Orhan , Johnson Kevin M , Pieske Burkert , Hansmann Jochen , Schulz-Menger Jeanette , Kelle Sebastian 
Published: February 2020

AbstractMyocardial strain is a convenient parameter to quantify left ventricular (LV) function. Fast strain-encoding (fSENC) enables the acquisition of cardiovascular magnetic resonance images for strain-measurement within a few heartbeats during free-breathing. It is necessary to analyze inter-vendor agreement of techniques to determine strain, such as fSENC, in order to compare existing studies and plan multi-center studies. Therefore, the aim of this study was to investigate inter-vendor agreement and test-retest reproducibility of fSENC for three major MRI-vendors. fSENC-images were acquired three times in the same group of 15 healthy volunteers using 3 Tesla scanners from three different vendors: at the German Heart Institute Berlin, the Charité University Medicine Berlin-Campus Buch and the Theresien-Hospital Mannheim. Volunteers were scanned using the same imaging protocol composed of two fSENC-acquisitions, a 15-min break and another two fSENC-acquisitions. LV global longitudinal and circumferential strain (GLS, GCS) were analyzed by a trained observer (Myostrain 5.0, Myocardial Solutions) and for nine volunteers repeatedly by another observer. Inter-vendor agreement was determined using Bland-Altman analysis. Test-retest reproducibility and intra- and inter-observer reproducibility were analyzed using intraclass correlation coefficient (ICC) and coefficients of variation (CoV). Inter-vendor agreement between all three sites was good for GLS and GCS, with biases of 0.01–1.88%. Test-retest reproducibility of scans before and after the break was high, shown by ICC- and CoV values of 0.63–0.97 and 3–9% for GLS and 0.69–0.82 and 4–7% for GCS, respectively. Intra- and inter-observer reproducibility were excellent for both parameters (ICC of 0.77–0.99, CoV of 2–5%). This trial demonstrates good inter-vendor agreement and test–retest reproducibility of GLS and GCS measurements, acquired at three different scanners from three different vendors using fSENC. The results indicate that it is necessary to account for a possible bias (< 2%) when comparing strain measurements of different scanners. Technical differences between scanners, which impact inter-vendor agreement, should be further analyzed and minimized.DRKS Registration Number: 00013253.Universal Trial Number (UTN): U1111-1207-5874.
The impacts of climate change on Greek airports
Authors: Gratton Guy , Padhra Anil , Rapsomanikis Spyridon , Williams Paul D. 
Published: February 2020

AbstractTime series of meteorological parameters at ten Greek airports since 1955 indicated the level of climate change in the Eastern Mediterranean area. Using this data, take-off performance was analysed for the DHC-8-400—a typical short range turboprop airliner, and the A320, a typical medium scale turbofan airliner. For airports with longer runways, a steady but unimportant increase in take-off distances was found. For airports with shorter runways, the results indicate a steady reduction in available payload. At the most extreme case, results show that for an Airbus A320, operating from the, relatively short, 1511m runway at Chios Airport, the required reduction in payload would be equivalent to 38 passengers with their luggage, or fuel for 700 nautical miles (1300 km) per flight, for the period between the A320’s entry to service in 1988 and 2017. These results indicate that for airports where aeroplane maximum take-off mass is a performance limited function of runway length, and where minimum temperatures have increased and/or mean headwind components decreased, climate change has already had a marked impact on the economic activity in the airline industry. Similar analyses could be usefully carried out for other runway-length–limited airports, which may often include island airports. It is also noted that previous research has only considered temperature effects, and not wind effects. Wind effects in this study are less significant than temperature, but nonetheless have an effect on both field performance noise and pollution nuisance around airports.
Cubic bent functions outside the completed Maiorana-McFarland class
Authors: Polujan Alexandr A. , Pott Alexander 
Published: February 2020

AbstractIn this paper we prove that in opposite to the cases of 6 and 8 variables, the Maiorana-McFarland construction does not describe the whole class of cubic bent functions in n variables for all $$n\ge 10$$

n
≥
10

. Moreover, we show that for almost all values of n, these functions can simultaneously be homogeneous and have no affine derivatives.
Oscillometric versus invasive blood pressure measurement in patients with shock: a prospective observational study in the emergency department
Authors: Meidert Agnes S. , Dolch Michael E. , Mühlbauer Konstanze , Zwissler Bernhard , Klein Matthias , Briegel Josef , Czerner Stephan 
Published: February 2020

AbstractIn emergency medicine, blood pressure is often measured by an oscillometric device using an upper arm cuff. However, measurement accuracy of this technique in patients suffering from hypotensive shock has not been sufficiently evaluated. We designed a prospective observational study investigating the accuracy of an oscillometric device in hypotensive patients admitted to the resuscitation area of the emergency department. Patients admitted to the resuscitation area of a university hospital, who were equipped with an arterial catheter and found to be hypotensive (mean arterial pressure (MAP) < 60 mmHg) were eligible for the study. Blood pressure was measured simultaneously via upper arm cuff and invasively under routine clinical conditions. After data extraction, Bland–Altman analysis, correlation coefficient and percentage error of mean and systolic blood pressure pairs were performed. We analysed 75 simultaneously obtained blood pressure measurements of 30 patients in hypotension, 11 (37%) were female, median age was 76.5 years (IQR 63–82). Oscillometric MAP was markedly higher than invasive MAP with a mean of the differences of 13 ± 15 mmHg (oscillometric—invasive), 95% limits of agreement − 16 to 41 mmHg, percentage error was 76%. In 64% of readings, values obtained by the upper arm cuff were not able to detect hypotension. Oscillometric blood pressure measurement is not able to reliably detect hypotension in emergency patients. Therefore, direct measurement of blood pressure should be established as soon as possible in patients suffering from shock.
Identification and Synthesis of Putative Pheromone Components of the Threatened Salt Marsh Bagworm Moth, Whittleia retiella (Lepidoptera: Psychidae)
Authors: Rahmani Rizan , Carrasco David , Svensson Glenn P. , Roweck Hartmut , Ryrholm Nils , Larsson Mattias C. , Hedenström Erik 
Published: February 2020

AbstractWhittleia retiella (Newman, 1847) is a threatened salt marsh species of the bagworm moth family Psychidae. For its preservation it is necessary to develop efficient tools to survey its distribution and habitat requirements in order to use appropriate conservation methods. Such tools may be pheromone-based monitoring systems, which have documented efficacy in establishing the occurrence of cryptic insect species in nature. By using gas chromatography combined with electroantennographic detection (GC-EAD), we found two compounds in female W. retiella headspace samples and whole-body extracts that elicited electrophysiological activity in male antennae. Gas chromatograpy coupled with mass spectrometry (GC-MS) operating in electron impact (EI) mode and comparison of the analytical data with those of synthetic reference compounds showed the chemical structures of these putative pheromone components to be (1S)-1-methylpropyl (5Z)-dec-5-enoate and 1-methylethyl (5Z)-dec-5-enoate. Field assays using baits loaded with synthetic compounds revealed that conspecific males were attracted to (1S)-1-methylpropyl (5Z)-dec-5-enoate alone or in combination with 1-methylethyl (5Z)-dec-5-enoate, whereas 1-methylethyl (5Z)-dec-5-enoate neither attracted nor repelled males in the field assays when tested alone. This study shows the potential of using (1S)-1-methylpropyl (5Z)-dec-5-enoate for monitoring W. retiella to gather more detailed information about the geographic distribution and habitat needs of this rare moth.
Orodispersible films as a personalized dosage form for nursing home residents, an exploratory study
Authors: Visser J. Carolina , Wibier Lisa , Mekhaeil Marina , Woerdenbag Herman J. , Taxis Katja 
Published: February 2020

AbstractBackground A frequent problem in ageing patients, and thus in nursing home residents, is dysphagia, affecting the ability to swallow solid dosage forms. A promising and personalized drug delivery system for this patient group is the orodispersible film. Orodispersible films could be prepared extemporaneously in a (hospital) pharmacy setting or in specialty compounding community pharmacies using the solvent casting method. Little has been done to systematically investigate which medications should be chosen for orodispersible film formulation development. Objective In this study, the medication use of nursing home residents was examined to identify medications that are suitable for orodispersible film formulation development. Setting Nursing homes of three Northern provinces of Netherlands. Method Medication intake data from 427 nursing home residents from nine nursing homes from the three northern provinces of the Netherlands were used to identify candidates for orodispersible film formulation development. A stepwise approach, with exclusion steps, was used. Selection criteria included systemic use with a maximum amount of 100 mg per dose unit, no commercially available suitable dosage forms for administration in dysphagia, indication for diseases associated with dysphagia. Furthermore, the characteristics of the active pharmaceutical ingredient needed for the orodispersible film formulation development, such as water solubility and taste, were reviewed. Main outcome measure Active pharmaceutical ingredients suitable for orodispersible film formulation development. Results The nursing home residents used three hundred forty one different medications. Of those, 34 active pharmaceutical ingredients from six therapeutic groups were considered as candidates for orodispersible film formulation development. Most of these active pharmaceutical ingredients have a bitter taste and poor water solubility, which is a challenge for orodispersible film production. Conclusions The most suitable active pharmaceutical ingredient candidates for manufacturing of orodispersible films for the ageing patient population may be the combination of levodopa and carbidopa used to treat the symptoms of Parkinson’s disease, and baclofen used to treat spasticity.
Teaching Conflicts of Interest and Shared Decision-Making to Improve Risk Communication: a Randomized Controlled Trial
Authors: Koch Cora , Dreimüller Nadine , Weißkircher Janosch , Deis Nicole , Gaitzsch Eva , Wagner Stefanie , Stoll Marlene , Bäßler Franziska , Lieb Klaus , Jünger Jana 
Published: February 2020

AbstractBackgroundRisk communication is a core aspect of a physician’s work and a fundamental prerequisite for successful shared decision-making. However, many physicians are not able to adequately communicate risks to patients due to a lack of understanding of statistics as well as inadequate management of conflicts of interest (COI).ObjectiveTo evaluate the effects of an integrated curriculum encompassing COI and shared decision-making on the participants’ risk communication competence, that is, their competence to advise patients on the benefits and harms of diagnostic or therapeutic interventions.DesignA rater-blind randomized controlled trial with a 30 (± 1)-week follow-up conducted from October 2016 to June 2017 at two German academic medical centers.ParticipantsSixty-three medical students in their fourth or fifth year.InterventionsParticipants received either a newly developed 15-h curriculum or a course manual adapted from teaching as usual.Main MeasuresPrimary outcome: change in risk communication performance in a video-observed structured clinical examination (VOSCE).Key ResultsParticipants were 25.7 years old on average (SD 3.6); 73% (46/63) were female. Increase in risk communication performance was significantly higher in the intervention group with post-intervention Cohen’sdof 2.35 (95% confidence interval (CI) 1.62 to 3.01,p< 0.01) and of 1.83 (CI 1.13 to 2.47,p< 0.01) 30 (± 1) weeks later. Secondary outcomes with the exception of frequency of interactions with the pharmaceutical industry also showed relevant improvements in the intervention as compared with the control group (dbetween 0.91 and 2.04 (p< 0.001)).ConclusionsOur results show that an integrated curriculum encompassing COI and risk communication leads to a large and sustainable increase in risk communication performance. We interpret the large effect sizes to be a result of the integration of topics that are usually taught separately, leading to a more effective organization of knowledge.Trial Registration:The trial is registered in the International Clinical Trials Registry with the trial number DRKS00010890.
Exercise and cancer: a position statement from the Spanish Society of Medical Oncology
Authors: Pollán M. , Casla-Barrio S. , Alfaro J. , Esteban C. , Segui-Palmer M. A. , Lucia A. , Martín M. 
Published: February 2020

AbstractDue to improvements in the number of cancer survivors and survival time, there is a growing interest in healthy behaviors, such as physical activity (PA), and their potential impact on cancer- and non-cancer-related morbidity in individuals with cancer. Commissioned by the Spanish Society of Medical Oncology (SEOM), in this review, we sought to distill the most recent evidence on this topic, focusing on the mechanisms that underpin the effects of PA on cancer, the role of PA in cancer prevention and in the prognosis of cancer and practical recommendations for clinicians regarding PA counseling. Despite the available information, the introduction of exercise programs into the global management of cancer patients remains a challenge with several areas of uncertainty. Among others, the most effective behavioral interventions to achieve long-term changes in a patient’s lifestyle and the optimal intensity and duration of PA should be defined with more precision in future studies.
Later Life Sex and Rubin’s ‘Charmed Circle’
Authors: Jones Rebecca L. 
Published: February 2020

AbstractGayle Rubin’s now classic concept of the ‘charmed circle’ has been much used by scholars of sexuality to discuss the ways in which some types of sex are privileged over others. In this paper, I apply the concept of the charmed circle to a new topic—later life—in order both to add to theory about later life sex and to add an older-age lens to thinking about sex hierarchies. Traditional discursive resources around older people’s sexual activities, which treat older people’s sex as inherently beyond the charmed circle, now coexist with new imperatives for older people to remain sexually active as part of a wider project of ‘successful’ or ‘active’ ageing. Drawing on the now-substantial academic literature about later life sex, I discuss some of the ways in which redrawing the charmed circle to include some older people’s sex may paradoxically entail the use of technologies beyond the charmed circle of ‘good, normal, natural, blessed’ sex. Sex in later life also generates some noteworthy inversions in which types of sex are privileged and which treated as less desirable, in relation to marriage and procreation. Ageing may, furthermore, make available new possibilities to redefine what constitutes ‘good’ sex and to refuse compulsory sexuality altogether, without encountering stigma.
Evaluation and Analysis of Battery Technologies Applied to Grid-Level Energy Storage Systems Based on Rough Set Theory
Authors: Xie Zhiyuan , Du Liang , Lv Xiaojun , Wang Qing , Huang Jianglei , Fu Tianyi , Li Shengyue 
Published: February 2020

AbstractInterest in the development of grid-level energy storage systems has increased over the years. As one of the most popular energy storage technologies currently available, batteries offer a number of high-value opportunities due to their rapid responses, flexible installation, and excellent performances. However, because of the complexity, multifunctionality, and wide deployment of power grids, trade-offs in battery performance exist, especially when considering economics, environmental effects, and safety. Therefore, establishing a comprehensive assessment of battery technologies is an urgent undertaking. In this work, we present an analysis of rough sets to evaluate the integration of battery systems (e.g., lead–acid batteries, lithium-ion batteries, nickel/metal–hydrogen batteries, zinc–air batteries, and Na–S batteries) into a power grid. Specifically, technological properties, economic significance, environmental effects, and safety of these battery systems are evaluated on the basis of rough set theory. In addition, some perspectives are provided to promote the development of battery technologies for grid-level energy storage.
Indications for stenting of coarctation of the aorta in children under 3 months of age
Authors: Krasemann T. , van Beynum I. , Dalinghaus M. , van Leuwen W. , Bogers A. , van de Woestijne P. 
Published: February 2020

AbstractIntroductionCoarctation of the aorta in children under 3 months of age is usually treated surgically. However, there are clinical scenarios in which stenting of native or recurrent coarctation may become necessary in this age group.Case reportsFour cases illustrate possible indications: left ventricular dysfunction increasing the operative risk, thrombus formation after coarctation surgery, patient size (i.e. in premature babies), and retrograde arch obstruction after hybrid palliation of hypoplastic left heart syndrome. In all babies, coarctation stenting was carried out successfully without complications.ConclusionCoarctation stenting can be carried out safely in small children. Usually, the stent has to be removed or redilated later. Results are encouraging.
Ultrasound molecular imaging: insights into cardiovascular pathology
Authors: Ozawa Koya , Lindner Jonathan R. 
Published: February 2020

AbstractSimilar to what has already occurred in cancer medicine, the management of cardiovascular conditions will likely be improved by non-invasive molecular imaging technologies that can provide earlier or more accurate diagnosis. These techniques are already having a positive impact in pre-clinical research by providing insight into pathophysiology or efficacy of new therapies. Contrast enhanced ultrasound (CEU) molecular imaging is a technique that relies on the ultrasound detection of targeted microbubble contrast agents to examine molecular or cellular events that occur at the blood pool-endothelial interface. CEU molecular imaging techniques have been developed that are able to provide unique information on atherosclerosis, ischemia reperfusion injury, angiogenesis, vascular inflammation, and thrombus formation. Accordingly, CEU has the potential to be used in a wide variety of circumstances to detect disease early or at the bedside, and to guide appropriate therapy based on vascular phenotype. This review will describe the physical basis for CEU molecular imaging, and the specific disease processes for the pre-clinical translational research experience.
Sedimentological and stratigraphic analyses as a guide for reservoir quality prediction and distribution: a case study of X1 and X2 reservoirs in Koca field, Niger delta
Authors: Njoku Kelechi Victoria 
Published: February 2020

AbstractThe basic architecture of reservoir models is heavily impacted by the stratigraphic interpretation. The estimation of in-place hydrocarbon volumes and recoverable hydrocarbon volumes will rely on the accuracy of predicting and distributing reservoir quality away from well control. In this paper the interpretation of sedimentological and stratigraphic analyses is used to define reservoir geometry, lateral continuity and determine technique needed for 3D static modelling. The objective of this study is to use a sequence stratigraphic framework and depositional model to predict the characteristic fabric of X1 and X2 reservoirs in unknown portions of the field. Log motifs from four wells (Koca-01, Koca-02, Koca-03 and Koca-04) and core report from a nearby well Z07 were used to classify facies types. Biostratigraphy data from Koca-01 were used to identify key stratigraphic markers. A sequence stratigraphic framework of the facies was built and correlated across the field. This interpretation was further used to build a conceptual depositional model that best represented the environment of deposition for these reservoirs. Results show the major facies associations as distributary channels and shoreface sands. X1 and X2 reservoirs are interpreted to be progradational sands within a highstand system tract. Correlation shows good sand connectivity and distribution of gross reservoir thickness in 2D. The depositional model in this paper was used in 3D static models to improve geometric characterization in 3D static modelling.
Functions of capillary pressure and dissolution in the CO2-flooding process in low-permeability reservoirs
Authors: Huang Xiaoliang , Qi Zhilin , Yan Wende , Yuan Yingzhong , Tian Jie , Qin Tianbao 
Published: February 2020

AbstractCO2 flooding has become one of most effective methods to improve oil recovery in low-permeability reservoirs. Thus, influencing factors have been specifically analyzed for their impact on oil displacement. Factors that are difficult to observe, such as capillary pressure and CO2 dissolution, have often been neglected in specific analysis. To do so, this paper combined laboratory experimentation with numerical simulation analysis to understand the specific functions of capillary pressure and CO2 dissolution in the CO2-flooding process in low-permeability reservoirs. Based on laboratory experiments with long cores applying different CO2-flooding methods, the authors established a one-dimensional numerical simulation model for CO2 flooding. After that, the model was simulated to analyze the effects of capillary pressure and CO2 dissolution for different CO2-flooding processes. The results show that the function of capillary pressure in different CO2-flooding modes is not consistent in low-permeability reservoirs; furthermore, capillary pressure is a driving force in the process of flooding and is a resistance force in the CO2-flooding process after pressure recovery. When considering CO2 dissolution in different flooding modes, its function was shown to be inconsistent in low-permeability reservoirs compared with CO2 flooding without considering CO2 dissolution; oil recovery is reduced in the CO2-flooding process, but oil recovery increases in the CO2-flooding process after pressure recovery. Therefore, in order to promote the rational and effective development of low-permeability reservoirs, it is necessary to understand the functions of capillary pressure and CO2 dissolution clearly in the process of CO2 flooding.