bluuebunny/crossref_metadata_2025_split huggingface dataset:
The process and project approach as the basis for harmonization of development management system of a construction company
Authors: Dorofeeva V V , Kaverzina L A , Nuzhina I P 
Published: September 2020

Abstract
The article is devoted to development of theoretical positions as well as methodical and practical base for increasing the efficiency of cost management of construction project realization. The modernized organization and economic mechanism of formation and cost management of the construction project realization is proposed. This mechanism is determined as integrated system of planning and control for the cost of construction project realization. The main directions of harmonization of components of company’s development due management system due to the process and project approach that combines advantages of value-oriented management and methodology of project management are indicated.
Polyatomic molecules as quantum sensors for fundamental physics
Authors: Hutzler Nicholas R 
Published: September 2020

Abstract
Precision measurements in molecules have advanced rapidly in recent years through developments in techniques to cool, trap, and control. The complexity of molecules makes them a challenge to study, but also offers opportunities for enhanced sensitivity to many interesting effects. Polyatomic molecules offer additional complexity compared to diatomic molecules, yet are still ‘simple’ enough to be laser-cooled and controlled. While laser cooling molecules is still a research frontier itself, there are many proposed and ongoing experiments seeking to combine the advanced control enabled by ultracold temperatures with the intrinsic sensitivity of molecules. In this perspective, we discuss some applications where laser-cooled polyatomic molecules may offer advantages for precision measurements of fundamental physics, both within and beyond the Standard Model.
The average value of the spin squared operator as an order parameter for spin phase transitions without spontaneous lowering of symmetry
Authors: Kalita V M , Levchenko G G 
Published: September 2020

Abstract
Phase transitions from the low-spin to the high-spin state are a unique physical phenomenon without lowering of symmetry. In contrast to magnetic phase transitions, for which vector or tensor of physical quantities are used as order parameters, we have shown that for spin phase transitions the order parameter is a scalar quantity—the thermodynamic mean of spin square operator, which was not previously used at all in the theory of phase transitions. The free energy in the form of a functional of this order parameter is determined, and the phase diagrams for spin transitions are constructed. The influence of the pressure on spin transition is analyzed also. It is shown that the spin Hamiltonian with this order parameter allows one to obtain all possible spin transformations in compounds. At the same time, this order parameter correctly reflects the physical nature of the spin transition phenomena.
Solution plasma: new synthesis method of N-doped carbon dots as ultra-sensitive fluorescence detector for 2,4,6-trinitrophenol
Authors: Kim Kyusung , Chokradjaroen Chayanaphat , Saito Nagahiro 
Published: September 2020

Abstract
Herein, we report the synthesis of nitrogen-doped carbon dots (NCDs) through solution plasma (SP) for the first time. The SP method occurs a rapid dissociation of molecules, such as organic compounds, caused by an electrical discharge between electrodes immersed in a solution. The dissociation can result in the creation of various radicals such as ·C2, ·CN, and ·H which enable the rapid synthesis of carbon dots (CDs). The unique reaction of radicals allowed the formation of CDs with high N concentration and functionalization of the surface in a short time. In this study, by using the SP method, a very fine NCDs with size of 6 nm were synthesized from a pyridine/water mixture in just 10 min. Bright blue fluorescence (410 nm) with a high quantum yield (61%) was observed due to the high N concentration and the surface passivation. From the potential application point of view, the synthesized NCDs showed an excellent detection property for 2,4,6-trinitrophenol (TNP) by fluorescence quenching effect. It was due to rich amino-functional groups which act as a reaction pathway to TNP. This phenomenon was caused by the synergetic effect of a photo-induced electron transfer with the assistance of proton transfer-assisted electron transfer.
Perivascular Epithelioid Cell Tumor of Urinary Bladder
Authors: Wu You-li , Lang Lang , Ma Qiang , Wu Feng , Zhang Yu , Chen Wei , Yan Xiao-chu , Duan Guang-jie 
Published: September 2020

Abstract

Objectives
To review the clinicopathologic features of perivascular epithelioid cell tumor (PEComa) of the urinary bladder.

Methods
Seven cases of bladder PEComa were studied by light microscopy, immunohistochemistry, and fluorescence in situ hybridization (FISH).

Results
In our 7 cases, 5 patients were female and 2 were male, with ages between 26 and 78 years. Patients presented with hematuria and recurrent abdominal discomfort as the main clinical symptoms. Microscopically, the epithelioid and spindle-shaped tumor cells with clear to granular eosinophilic cytoplasm were arranged in fascicular, acinar, or nested patterns. The tumor cells were positive for HMB45, melan-A, and SMA, but no TFE3 gene rearrangement was detected in any of the 7 samples by FISH. The analysis of all 35 cases from the literature and ours showed a patient age range from 16 to 78 years (mean age, 39 years), a male-to-female ratio of 1:1.3, maximal tumor diameters from 0.6 to 18.8 cm (mean, 4.5 cm). With a mean follow-up of 27 months, the recurrence, metastasis, and mortality rates were 10.7%, 10.7%, and 7.1%, respectively.

Conclusions
Bladder PEComa is extremely rare, remains a diagnostic challenge, and needs more attention. Strengthening the understanding of this tumor will improve diagnostic accuracy.
Reprinting the Past/Re-Ordering Black Social Life
Authors: Womack Autumn 
Published: September 2020

Abstract
This essay recovers the cultural and political history of Arno Press’s landmark republication project, The American Negro: His History and Literature. Within the context of the “reprint revolution,” the period when large publishing houses clamored to publish African American texts, many of which had long been out of print, and with the backing of The New York Times, Arno Press reissued hundreds of titles by and about Black life. While these titles have come to shape the contours of African American literary scholarship, the project was immediately ensnared within debates about the future of Black political life. Knitting together personal correspondence, advertisements, and reviews, this essay situates the Arno Press endeavor with a longer history of Black print culture in which the past was harnessed in the name of imagining new political futures. Yet, within the context of the late 1960s “reprint revolution,” I show how the Black past was summoned in the service of a liberal fantasy of assimilation, social management, and racial reform. Drawing a line of connection between the technology of reprinting and its ideological workings, this essay calls for a critical consideration of the labor that we invite Black texts to undertake in the service of particular, and often limited, political visions.
Sample-specific perturbation of gene interactions identifies breast cancer subtypes
Authors: Chen Yuanyuan , Gu Yu , Hu Zixi , Sun Xiao 
Published: September 2020

AbstractBreast cancer is a highly heterogeneous disease, and there are many forms of categorization for breast cancer based on gene expression profiles. Gene expression profiles are variables and may show differences if measured at different time points or under different conditions. In contrast, biological networks are relatively stable over time and under different conditions. In this study, we used a gene interaction network from a new point of view to explore the subtypes of breast cancer based on individual-specific edge perturbations measured by relative gene expression value. Our study reveals that there are four breast cancer subtypes based on gene interaction perturbations at the individual level. The new network-based subtypes of breast cancer show strong heterogeneity in prognosis, somatic mutations, phenotypic changes and enriched pathways. The network-based subtypes are closely related to the PAM50 subtypes and immunohistochemistry index. This work helps us to better understand the heterogeneity and mechanisms of breast cancer from a network perspective.
CellTalkDB: a manually curated database of ligand–receptor interactions in humans and mice
Authors: Shao Xin , Liao Jie , Li Chengyu , Lu Xiaoyan , Cheng Junyun , Fan Xiaohui 
Published: September 2020

AbstractCell–cell communications in multicellular organisms generally involve secreted ligand–receptor (LR) interactions, which is vital for various biological phenomena. Recent advancements in single-cell RNA sequencing (scRNA-seq) have effectively resolved cellular phenotypic heterogeneity and the cell-type composition of complex tissues, facilitating the systematic investigation of cell–cell communications at single-cell resolution. However, assessment of chemical-signal-dependent cell–cell communication through scRNA-seq relies heavily on prior knowledge of LR interaction pairs. We constructed CellTalkDB (http://tcm.zju.edu.cn/celltalkdb), a manually curated comprehensive database of LR interaction pairs in humans and mice comprising 3398 human LR pairs and 2033 mouse LR pairs, through text mining and manual verification of known protein–protein interactions using the STRING database, with literature-supported evidence for each pair. Compared with SingleCellSignalR, the largest LR-pair resource, CellTalkDB includes not only 2033 mouse LR pairs but also 377 additional human LR pairs. In conclusion, the data on human and mouse LR pairs contained in CellTalkDB could help to further the inference and understanding of the LR-interaction-based cell–cell communications, which might provide new insights into the mechanism underlying biological processes.
Low-frequency transcranial stimulation of pre-supplementary motor area alleviates levodopa-induced dyskinesia in Parkinson’s disease: a randomized cross-over trial
Authors: Lohse Allan , Meder David , Nielsen Silas , Lund Anders Elkjær , Herz Damian M , Løkkegaard Annemette , Siebner Hartwig R 
Published: September 2020

Abstract
Levodopa-induced dyskinesia gradually emerges during long-term dopamine therapy, causing major disability in patients with Parkinson disease. Using pharmacodynamic functional MRI, we have previously shown that the intake of levodopa triggers an excessive activation of the pre-supplementary motor area in Parkinson disease patients with peak-of-dose dyskinesia. In this pre-registered, interventional study, we tested whether the abnormal responsiveness of the pre-supplementary motor area to levodopa may constitute a ‘stimulation target’ for treating dyskinesia. A gender-balanced group of 17 Parkinson disease patients with peak-of-dose dyskinesia received 30 min of robot-assisted repetitive transcranial magnetic stimulation, after they had paused their anti-Parkinson medication. Real-repetitive transcranial magnetic stimulation at 100% or sham-repetitive transcranial magnetic stimulation at 30% of individual resting corticomotor threshold of left first dorsal interosseous muscle was applied on separate days in counterbalanced order. Following repetitive transcranial magnetic stimulation, patients took 200 mg of oral levodopa and underwent functional MRI to map brain activity, while they performed the same go/no-go task as in our previous study. Blinded video assessment revealed that real-repetitive transcranial magnetic stimulation delayed the onset of dyskinesia and reduced its severity relative to sham-repetitive transcranial magnetic stimulation. Individual improvement in dyskinesia severity scaled linearly with the modulatory effect of real-repetitive transcranial magnetic stimulation on task-related activation in the pre-supplementary motor area. Stimulation-induced delay in dyskinesia onset correlated positively with the induced electrical field strength in the pre-supplementary motor area. Our results provide converging evidence that the levodopa-triggered increase in pre-supplementary motor area activity plays a causal role in the pathophysiology of peak-of-dose dyskinesia and constitutes a promising cortical target for brain stimulation therapy.
Creatinine and C-reactive protein in amyotrophic lateral sclerosis, multiple sclerosis and Parkinson’s disease
Authors: Cui Can , Sun Jiangwei , Pawitan Yudi , Piehl Fredrik , Chen Honglei , Ingre Caroline , Wirdefeldt Karin , Evans Marie , Andersson John , Carrero Juan-Jesus , Fang Fang 
Published: September 2020

Abstract
Serum creatinine and C-reactive protein have been proposed as potential biomarkers for neurodegenerative diseases, including amyotrophic lateral sclerosis, multiple sclerosis and Parkinson’s disease. However, longitudinal studies investigating temporal patterns of these biomarkers, including the phase before diagnosis, are rare. We performed a case–control study including all newly diagnosed patients with amyotrophic lateral sclerosis (N = 525), multiple sclerosis (N = 1815) or Parkinson’s disease (N = 3797) during 2006–2013 in Stockholm, Sweden, who participated in the Stockholm CREAtinine Measurements (SCREAM) project. For each case, we randomly selected up to five controls from SCREAM that were individually matched to the case by age, sex and county of residence (N = 2625 for amyotrophic lateral sclerosis, N = 9063 for multiple sclerosis and 18 960 for Parkinson’s disease). We collected for both the cases and the controls testing results of serum creatinine and C-reactive protein performed by healthcare providers in Stockholm during the study period. Median levels of creatinine and C-reactive protein were visualized using locally weighted smoothing curves among cases and controls. A linear mixed model was also applied to explore temporal changes within an individual. Compared to controls, patients with amyotrophic lateral sclerosis had lower levels of creatinine from 2 years before diagnosis onwards. In contrast, patients with amyotrophic lateral sclerosis had lower levels of C-reactive protein before diagnosis but higher levels after diagnosis, compared to controls. Focusing the 2 years before to 2 years after diagnosis, patients with amyotrophic lateral sclerosis displayed statistically significantly decreasing level of creatinine from 1 year before diagnosis until 2 years after diagnosis, whereas increasing level of C-reactive protein from diagnosis until 2 years after diagnosis. There were no similar patterns noted among patients with multiple sclerosis or Parkinson’s disease, or the controls of the three patient groups. Patients with amyotrophic lateral sclerosis display distinct temporal patterns of creatinine and C-reactive protein before and after diagnosis, compared to amyotrophic lateral sclerosis-free controls or patients with multiple sclerosis and Parkinson’s disease.
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study
Authors: Papandreou Christopher , Bulló Mònica , Hernández-Alonso Pablo , Ruiz-Canela Miguel , Li Jun , Guasch-Ferré Marta , Toledo Estefanía , Clish Clary , Corella Dolores , Estruch Ramon , Ros Emilio , Fitó Montserrat , Alonso-Gómez Angel , Fiol Miquel , Santos-Lozano José M , Serra-Majem Lluís , Liang Liming , Martínez-González Miguel A , Hu Frank B , Salas-Salvadó Jordi 
Published: September 2020

AbstractBackgroundFew studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF). This study sought to investigate these associations.MethodsProspective associations of these metabolites with incident AF and HF were examined among participants at high cardiovascular risk in the PREDIMED study (PREvención con DIeta MEDiterránea) after follow-up for about 10 years. Two nested case-control studies were conducted, including 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma levels of TMAO and its precursors were semi-quantitatively profiled with liquid chromatography tandem mass spectrometry. Odds ratios were estimated with multivariable conditional logistic regression models.ResultsAfter adjustment for classical risk factors and accounting for multiple testing, participants in the highest quartile vs. the lowest quartile of baseline choline and betaine levels had a higher risk of AF [OR (95% CI): 1.85 (1.30–2.63) and 1.57 (1.09–2.24), respectively]. The corresponding OR for AF for extreme quartiles of dimethylglycine was 1.39 (0.99–1.96). One SD increase in log-transformed dimethylglycine was positively associated with AF risk (OR, 1.17; 1.03–1.33). The corresponding ORs for HF for extreme quartiles of choline, betaine, and dimethylglycine were 2.51 (1.57–4.03), 1.65 (1.00–2.71) and 1.65 (1.04–2.61), respectively. TMAO and L-carnitine levels were not associated with AF or HF.ConclusionsOur findings support the role of the choline metabolic pathway in the pathogenesis of AF and HF.
The effects of cold shock on freshwater fish larvae and early-stage juveniles: implications for river management
Authors: Michie Laura E , Thiem Jason D , Boys Craig A , Mitrovic Simon M 
Published: September 2020

Abstract
Temperature is essential to the maintenance of optimal physiological functioning in aquatic organisms. Fish can manage natural fluctuations in temperature; however, in freshwater ecosystems acute and rapid temperature changes can originate from sources such as large dams and industrial effluents. These rapid temperature changes may induce several physiological and behavioural responses that can result in lethal and sub-lethal consequences. The present study assessed immediate sub-lethal and short-term (10 days) lethal responses of three species of Australian freshwater fish larvae and early-stage juveniles to a range of different ‘field-relevant’ cold shocks (−4, −6, −8 and −10°C). Murray cod (Maccullochella peelii), silver perch (Bidyanus bidyanus) and golden perch (Macquaria ambigua) were tested at two age groups to elucidate the interaction between ontogeny and sensitivity to cold shock. Cold shock caused mortality and reductions in swimming ability (time to exhaustion and lines crossed) in all species of fish at both age groups. Sensitivity was correlated to the magnitude of cold shock; a 10°C drop in temperature caused the highest mortalities. Ontogeny interacted with the severity of cold shock; the younger fish experienced higher mortalities and greater impairment to swimming ability. This study demonstrates the potential lethal and sub-lethal impacts of cold shock on freshwater fish at a critical life-history stage. Understanding the impacts of cold shock will aid management of freshwater ecosystems for the benefit of fish populations, with the current study identifying critical life stages to be considered in remediation and guiding thresholds necessary to reduce the impact of cold shock on native fish populations.
Diversity and genetic lineages of environmental staphylococci: a surface water overview
Authors: Silva Vanessa , Caniça Manuela , Capelo José L , Igrejas Gilberto , Poeta Patrícia 
Published: September 2020

ABSTRACTAntimicrobial resistance in the environmental dimension is one of the greatest challenges and emerging threats. The presence of resistant bacteria and resistance genes in the environment, especially in aquatic systems, has been a matter of growing concern in the past decade. Monitoring the presence of antimicrobial resistance species, in this particular case, Staphylococcus spp., in natural water environments could lead to a better understanding of the epidemiology of staphylococci infections. Thus, the investigation of natural waters as a potential reservoir and vehicle for transmission of these bacteria is imperative. Only a few studies have investigated the prevalence, antimicrobial resistance and genetic lineages of staphylococci in natural waters. Those studies reported a high diversity of staphylococci species and lineages in surface waters. Methicillin-resistant S. aureus were relatively prevalent in surface waters and, as expected, often presented a multidrug-resistant profile. There was a high diversity of S. aureus lineages in surface waters. The presence of S. aureus CC8 and CC5 suggests a human origin. Among the coagulase-negative staphylococci, the most frequently found in natural waters was S. warneri and S. epidermidis. These studies are extremely important to estimate the contribution of the aquatic environment in the spread of pathogenic bacteria.
Soil fungal community composition and functional similarity shift across distinct climatic conditions
Authors: Bui An , Orr Devyn , Lepori-Bui Michelle , Konicek Kelli , Young Hillary S , Moeller Holly V 
Published: September 2020

ABSTRACT
A large part of ecosystem function in woodland systems depends on soil fungal communities. However, global climate change has the potential to fundamentally alter these communities as fungal species are filtered with changing environmental conditions. In this study, we examined the potential effects of climate on host-associated (i.e. tree-associated) soil fungal communities at climatically distinct sites in the Tehachapi Mountains in California, where more arid conditions represent likely regional climate futures. We found that soil fungal community composition changes strongly across sites, with species richness and diversity being highest at the most arid site. However, host association may buffer the effects of climate on community composition, as host-associated fungal communities are more similar to each other across climatically distinct sites than the whole fungal community. Lastly, an examination of functional traits for ectomycorrhizal fungi, a well-studied guild of fungal mutualist species, showed that stress-tolerant traits were more abundant at arid sites than mesic sites, providing a mechanistic understanding of these community patterns. Taken together, our results indicate that fungal community composition will likely shift with future climate change but that host association may buffer these effects, with shifts in functional traits having implications for future ecosystem function.
Galleria mellonella as an infection model: an in-depth look at why it works and practical considerations for successful application
Authors: Pereira Monalessa Fábia , Rossi Ciro César , da Silva Giarlã Cunha , Rosa Jéssica Nogueira , Bazzolli Denise Mara Soares 
Published: September 2020

ABSTRACT
The larva of the greater wax moth Galleria mellonella is an increasingly popular model for assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents. In this review, we discuss details of the components of the G. mellonella larval immune system that underpin its use as an alternative infection model, and provide an updated overview of the state of the art of research with G. mellonella infection models to study bacterial virulence, and in the evaluation of antimicrobial efficacy. Emphasis is given to virulence studies with relevant human and veterinary pathogens, especially Escherichia coli and bacteria of the ESKAPE group. In addition, we make practical recommendations for larval rearing and testing, and overcoming potential limitations of the use of the model, which facilitate intra- and interlaboratory reproducibility.