bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Inpatients with Coronavirus Disease 2019 (COVID-19) at Risk of Clinical Deterioration: A Multicenter, Retrospective Cohort Study
Authors: Zhang Yi , Wu Xiaojing , Ni Lan , Chen Lei , Zhou Changzhi , Gao Chang , Xia Jingen , Tian Ye , Gu Sichao , Li Min , Feng Yingying , Duan Jun , Wang Yi , Xie Jungang , Guo Qiang , Zhao Jianping , Hu Yi , Cheng Zhenshun , Zhan Qingyuan 
Published: August 2020

Abstract
Background: Current information is not enough to recognize the risk factors of clinical deterioration and to make medical decisions in COVID-19 patients. Methods: A retrospective study was performed, with collecting data from medical records of COVID-19 patients in three designated hospitals from January 8, 2020 to May 6, 2020. Clinical data were analyzed between the deteriorated and the non-deteriorated patients, which was defined as either a increase of 2 categories on the modified 6-category ordinal scale, or a decline of PaO2-to-FIO2 ratio more than 100mmHg. Results: Total 238 patients with COVID-19 were selected, where 31 were deteriorated and 207 were non-deteriorated. In the deterioration group, the case fatality rate was up to 41.9%. Compared with non-deteriorated patients, the deteriorated were older (65.8[IQR 54.3-72.3] vs 54.4[41.0-66.1], p=0.004) and were more likely to have chronic medical illnesses (17[54.8%]) vs 92[44.4%]). Multivariable regression showed that three variables, neutrophil-lymphocyte ratio (NLR)≥3.66 (OR, 9.85; 95% CI, 1.68-57.57), hyponatremia (OR, 8.35; 95% CI, 1.74-40.16), and presence of ground-glass opacities with consolidation (OR, 5.84; 95% CI, 1.24-27.49) were associated with increased odds of clinical deterioration. The variable that inspiring air or traditional oxygen therapy only within 72 hours after admission, indicated a decreased odd of illness progression (OR, 0.075; 95% CI, 0.012–0.465).Conclusions: COVID-19 patients with clinical deterioration had more common extra-pulmonary organ impair in early stage and high case fatality rate. Three factors, NLR ≥3.66, hyponatremia and presence of ground-glass opacities with consolidation were determined as high risk factors in deterioration.
Evaluation of the Predictive Power of the Theory of Planned Behavior on the Intention of Pregnant Women to Neonatal Care
Authors: Navabi Azamalsadat , shamsi mohsen , khorsandi mahboobeh , zamanian Maryam 
Published: August 2020

Abstract
Background: Considering that neonatal are the most sensitive group to kind of diseases, the present study aimed to evaluation of the predictive power of the Theory of Planned Behavior on the intention of pregnant women to neonatal care.Method: In this cross-sectional study, 100 pregnant women in trimester of pregnancy were selected by random sampling. Data was collected using valid and reliable questionnaire and interviews conducted with pregnant women. The questionnaire included demographic characteristic of the mothers and theory planned behavior construct. Finally the data were analyzed by SPSS 20 T-test, Chi-square, Correlation, ANOVA and regression. Results: The average age of the sample was 26.12±4.9 and the average duration of marriage age was 3.9 ±2.74 years. There was a high correlation between perceived behavioral control and behavioral intention (r=0.40; p < 0.001). Over 40% of pregnant women were shown to lack overall Knowledge about the items related to neonatal care. The mothers who were better prepared for parenting tended to have a higher level of schooling, perceived control behavior and knowledge. Regression analysis showed that the knowledge and perceived behavior control R2 =32% in the prediction of neonatal care intentions.Conclusions: Findings of this study show support for the predictive ability of the theory of planned behavior in predicting for neonatal care therefore the design of educational intervention should be based on intention and knowledge as the most important predictors of maternal behavior.
Immediate Effects of Ischemic Compression Therapy on Myofascial Trigger Points on Pain, Mobility and Strength in Individuals With Subacromial Impingement Syndrome: A Single-arm Study
Authors: Nascimento José Diego Sales do , Alburquerque-Sendín Francisco , Ferreira Laysla Carla de Castro , Sousa Catarina de Oliveira 
Published: August 2020

Abstract
Background: The myofascial trigger points (MTPs) may be associated with in shoulder dysfunction.Objective: To evaluate the immediate effect of ischemic compression therapy (ICT) and to verify the effect of the evaluation protocol on MTPs, pain, mobility and strength of shoulder.Methods: 15 individuals were assessed for the amount of MTPs, pressure pain threshold (PPT), range of motion (ROM), isometric strength of shoulder muscles and pain in performing these tests. The evaluations took place 48 hours before the ICT, immediately before, and after the ICT.Results: There was a reduction in the total amount of MTPs (p<0.01; Cliff’s d=0.24-0.35) and an increase in the PPT in the middle deltoid muscle (p=0.03) in the comparisons pre and post treatment, while there was no difference in ROMs and strength measures (p>0.05). The pain was less during the sagittal elevation ROM (p<0.01; d=0.80) and internal rotation (p=0.05; d=0.57), and during the performance of strength in arm elevation and external rotation (p=0.01; d=0.72 and d=0.68). There was generally no difference in the variables assessed between baseline and pre-treatment (p>0.06).Conclusion: The ICT immediately reduced the amount of MTPs and pain during mobility and strength. The evaluation protocol did not influence the studied variables.Trial registration: ReBEC (RBR-3DDG2K). Registered in July 5th, 2017 – Retrospectively registered, http://www.ensaiosclinicos.gov.br/rg/RBR-3ddg2k/.
Dielectric Spectroscopy of the (K0.44Na0.52Li0.04)0.97La0.01Nb0.9Ta0.1O3 Ceramic Obtained by Sol-Gel
Authors: López-Noda R. , Portelles J. , Rojas-George G. , Reyes-Rojas A. , Fuentes J. , Rebellon-Watson J.F. , Hmŏk H'Linh , Cruz M.P. , Beltrones J.M. Siqueiros 
Published: August 2020

Abstract
(K0.44Na0.52Li0.04)0.97La0.01Nb0.9Ta0.1O3 lead free ceramics were synthesized by sol-gel method. Their morphology, crystal structure and spectroscopic dielectric properties were analyzed by the appropriate techniques. The co-existence of an orthorhombic and a tetragonal ferroelectric phase at room temperature is confirmed by Rietveld analysis. La and Li cations are effective in shifting down the ferroelectric transition temperatures. The tetragonal to cubic transition, (TT-C), takes place at 371 °C while the orthorhombic to tetragonal, (TO-T), occurs at 110 °C, and the maximum relative permittivity (ɛmax) at TT-C is 3000, which is among the highest for KNN-based ceramics obtained by different methods. Conductivity behaves according to Jonscher’s law in the frequency and temperature range of this study. The activation energy values corresponding to the different conduction mechanisms were obtained. The results were compared with those for the same composition obtained by combining the reactive template grain growth (RTGG) technique and the solid-state method.
Effect of crosstalk between Th17 and Th9 cells on the activation of dermal vascular smooth muscle cells in systemic sclerosis and regulation of tanshinone IIA
Authors: Liu Mengguo 
Published: August 2020

Abstract
Background: To evaluate the effect of T helper 17 (Th17) cells and Th9 cells on the activation of dermal vascular smooth muscle cells (DVSMCs) in systemic sclerosis (SSc) and regulation of tanshinone IIA. Methods: The expression of interleukin 17 receptor (IL-17R) and interleukin 9 receptor (IL-9R) in the skin of SSc patients was assessed by immunofluorescence. The expression of IL-9 and IL-9R mRNA in peripheral blood mononuclear cells (PBMCs) of SSc patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The proportion of Th9 cells in PBMCs of SSc patients was sorted by flow cytometry. The effect of IL-9 on the differentiation of Th17 and IL-17 on that of Th9 was detected by flow cytometry. The proportion of Th9 and Th17 cells in SSc patients was detected by flow cytometry. The level of collagen I, III, α-SMA, IL-9R, IL-17R, JNK, P38, and ERK were analyzed using Western blot (WB).Results: Th9 cells were highly expressed in SSc. IL-9 stimulated the differentiation of immature T cells into Th17 cells. IL-17 induced the differentiation of immature T cells into Th9 cells. Tanshinone IIA inhibited the differentiation of immature T lymphocytes into Th17 and Th9. WB showed that the combined action of IL-17 and IL-9 upregulated the inflammation and proliferation of DVSMCs. Anti-IL17, anti-IL9, and tanshinone IIA inhibited the functional activation of DVSMCs.Conclusions: The current results suggested that Th17 and Th9 cells induced the activation of DVSMCs in SSc through crosstalk in vitro, and tanshinone IIA inhibited the process.
Clinical Analysis of Prophylactic Para-Aortic Intensity-Modulated Radiation in Cervical Cancer
Authors: Jin Ge , Fan Xiaomei , Li Kuixiu , Niu Shuhuai , Liu Siyang , Zhang Qianying 
Published: August 2020

Abstract
Objective: To compare and evaluate survival, prognosis, treatment failure, and toxicity between two treatment regimens in cervical cancer patients radiologically diagnosed with pelvic lymphadenopathy and without para-aortic lymphadenopathy. Methods: Thirty-one patients with cervical cancer were prospectively selected for primarily treatment as the extended-field, intensity-modulated radiation group (EF-IMRT group), and 37 patients were chosen simultaneously as the pelvic intensity-modulated radiation group (P-IMRT group). Both groups were diagnosed with pelvic lymphadenopathy without para-aortic lymphadenopathy before treatment by radiology. Pelvic and para-aortic IMRT was employed in the EF-IMRT group, with an upper exposed level of the left renal vein, while pelvic IMRT was employed in P-IMRT group. Both groups were treated with high dose rate 192Ir brachytherapy and platinum-based concurrent chemotherapy. Results: In the short-term, there was no effective difference between the groups. Regarding long-term efficacy, the 3-year overall survival (OS), progression-free survival (PFS), and progression and metastasis-free survival (PAMFS) in the EF-IMRT group and P-IMRT group were 87.0% vs. 74.6%, 83.6% vs. 61.7% and 96.0% vs. 80.5%, respectively. Treatment regimens, tumor size, and radiation time were all independent prognostic factors of OS and PFS. Treatment regimens, tumor size, and total equivalent dose in 2 Gy/f (EQD2) of point A were independent prognostic factors of PAMFS.Conclusions: The risk of mortality, tumor progression, and metastasis in the para-aortic lymph nodes were significantly lower when using EF-IMRT than when using P-IMRT. EF-IMRT did not increase the incidence of gastrointestinal toxicities and genitourinary toxicities, and the toxicities at the late stages were mild.
A Novel Chemically-Modified Curcumin 2.24: Short-term Systemic Treatment for Natural Periodontitis in Dogs
Authors: DENG JIE , Golub Lorne M , Lee Hsi-ming , Bhatt Heta Dinesh , Hong Hou-Lin , Johnson Francis , Scaduto Joseph , Zimmerman Thomas , Gu Ying 
Published: August 2020

Abstract
Chronic periodontitis, a severe periodontal inflammatory disease, is initiated by the anaerobic microbial biofilm, however the tissue-breakdown is predominantly mediated by the host-response. The pathogenesis mediated by the latter is characterized by the generation of inflammatory mediators (e.g., cytokines), and the production of collagenolytic and tissue-destructive enzymes (especially the matrix metalloproteinases, MMPs) causing connective tissue and bone destruction. These biochemical changes, such as over-production of MMP-9, might be detected in the very-early stage of this disease/inflammatory process, even before apparent clinical manifestations. Interestingly, our pilot study of a short-term/1-month therapy of CMC2.24 (a novel chemically-modified curcumin) in the beagle dogs with naturally-occurring periodontitis indicated that, it did appear to significantly reduce both pro- and activated-MMP-9 in peripheral blood, compared to placebo group at early stage (1 month), prior to apparent clinical improvement at late stage (3 months). And therefore, MMP-9 may serve as an early and sensitive biomarker that can precede and predict future clinical changes in disease severity and response to treatment which we observed in our long-term study in this dog model of natural periodontitis.
LncRNA LINC00337 Sponges miR-1285-3p to Promote Proliferation and Metastasis of Lung Adenocarcinoma Cells Through Up-Regulating YTHDF1
Authors: Zhang Ru-nan , Wu Dong-mei , Wu Li-ping , Gao Guo-wei 
Published: August 2020

Abstract
Background: Emerging studies have attested that long noncoding RNAs (lncRNAs) predominantly functioned in carcinogenesis of multiple developing human tumors. The current research aimed at probing the underlying participation and mechanisms of LINC00337 in lung adenocarcinoma.Methods: Here we analyzed TCGA and GTEx datasets and chose LINC00337 as research object. Cell proliferation, cell apoptosis, cell cycle, and invasion were detected in gain and loss experiment of LINC00337 both in vitro and in vivo. Moreover, RNA pull-down, luciferase reporter assays, western blotting analysis, rescue experiment were performed to investigate underlying molecular mechanisms of LINC00337 function. Results: LINC00337 was remarkably increased in lung adenocarcinoma. Also, LINC00337 knock-down was unraveled to repress cell invasion and proliferation as well as cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo. With respect to mechanism, LINC00337 knock-down boosted miR-1285-3p to be expressed and then restrained YTHDF1 to be expressed post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully countered the influence on cell proliferation, invasion and apoptosis caused by LINC00337 shRNA.Conclusions: These results suggest that LINC00337 acted as an oncogenic lncRNA, targeting miR-1285-3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma.
Prospective validation of the BISHE score as a predictor of the need for massive transfusion in patients with upper gastrointestinal bleeding
Authors: Chen Yi-Chuan , Wu Kai-Siang , Hung Ming-Szu 
Published: August 2020

Abstract
Background: Emergency transfusion strategies for patients with upper gastrointestinal bleeding (UGIB) have not been well developed. The BISHE is a recently developed scoring system for prediction of patients likely to require massive transfusion but has not been validated. In this study, we evaluated the predictive ability of the BISHE score and that of a revised scoring system in an effort to improve care for patients with UGIB and allow better resource allocation. Methods: This prospective observational cohort study included patients who were admitted to our hospital between July 1, 2016 and June 30, 2019 and required massive transfusion (defined as receiving three units of red blood cells over one hour) in the emergency department. The predictive accuracy of the BISHE score and that of the revised scoring system were compared using area under the receiver-operating characteristic (AUROC) curve analysis. Results: Liver cirrhosis, an international normalized ratio >1.5, and hemoglobin <8.0 g/dL were independently associated (p<0.05) with requirement for massive transfusion. The revised scoring system discriminated successfully between patients with UGIB requiring massive transfusion and their counterparts who did not (AUROC 0.82, 95% confidence interval 0.78–0.86) and performed better than the BISHE score (AUROC 0.73, 95% confidence interval 0.69–0.76; p=0.004).Conclusions: Compared with the BISHE score, the revised scoring system was better able to identify patients likely to require massive transfusion.
Valuing Wetland Ecosystem in Ethiopia an Empirical Evidence with Choke Mountain: Application of Choice Experiment
Authors: Takele Melaku Tarekegn , Awoke Belaynesh , Merid Eshetie Woretaw 
Published: August 2020

Abstract
Ecosystem services have not market price. In Ethiopia, choke mountain wetland ecosystem has major contribution for providing water, regulating climate, and offering recreational. Valuing this natural resource helps to protect it from damage. The objective of the study is to value choke mountain wetland ecosystem by using choice experiment. To value it the attributes are biodiversity, recreational service, water availability, job opportunity, and monetary payment. Primary data was collected from 270 sample households. Both descriptive and econometrics analysis were conducted. The study found that households had good awareness about the choke mountain wetland ecosystem services. Mixed logit models were used for valuation, and all attributes are significant to affect the probability of choosing an alternative scenario. The study found that households gave higher value for biodiversity improvement than the rest and water availability is the least preferable attributes. The total WTP for the first and second alternatives was 7,133,034.216 and 7,031,211.146 respectively; it was high in the second alternative. Moreover, compensating surplus which reflect overall willingness to pay for a change from the status quo to alternative improvement scenarios were estimated. Estimated results for high improvement scenario and medium improvement scenario were ETB 2,119,457.028 and 1,955,828.606 respectively.
Exposure to Mycobacteria influences disease progression in COVID-19 patients&nbsp;
Authors: Gupta Ajay , Sural Sumit , Gupta Ayush , Rousa Shashank , B.C.Koner  , Bhalotra Anju , Chawla Rohit 
Published: August 2020

Abstract
Background: COVID-19−related deaths are significantly higher in countries with higher quality of life. A strong negative correlation is reported between the BCG index and COVID- 19 mortality. The present study explored if a high Th1immunity due to frequent exposure to strong Th1 antigens like Mycobacteria or Salmonella could be the cause for lesser COVID-19−related deaths in Indian population. Methods: This prospective comparative study was conducted with 3 groups of twenty patients each of mildly symptomatic (A), severely ill (S) Covid patients and healthy volunteers with a Covid Negative report (H).Results: All severely ill patients showed increased leucocyte counts, lymphopenia and raised D-dimer. A gross reversible unresponsiveness of T cells was seen among all patients in S group with absolutely no response even to the mitogen stimulus. Quantiferon TB test value and distribution of test positivity was significantly lower in group S. Three out of 6 survived patients in S group had positive Quantiferon TB test while 2 patients turned positive on repeat test and the sixth patient showed high TH titre on widal test.Conclusion: Altered Th1 immunity associated with frequent community exposure of tuberculosis and typhoid antigen in Indian population might be responsible for its relatively lesser prevalence and mortality following Covid-19.
Intracerebral hemorrhage in COVID-19 patients with pulmonary failure – a propensity score matched registry study
Authors: Lang Corinna N. , Dettinger Johanna S. , Berchtold-Herz Michael , Utzolino Stefan , Bemtgen Xavier , Zotzmann Viviane , Schmid Bonaventura , Biever Paul M. , Bode Christoph , Müller-Peltzer Katharina , Duerschmied Daniel , Wengenmayer Tobias , Niesen Wolf-Dirk , Staudacher Dawid L. 
Published: August 2020

Abstract
Background: Hypercoagulopathy in coronavirus disease 2019 (COVID-19) causing deep vein thrombosis and pulmonary artery embolism necessitate systemic anticoagulation. Case reports of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear however, if COVID-19 patients with acute respiratory distress syndrome (ARDS) with and without extracorporeal membrane oxygenation therapy (ECMO) have more intracerebral hemorrhages (ICH) compared to other ARDS patients.Methods: We conducted a retrospective observational single center study enrolling all patients with ARDS from 01/2018-05/2020. Patients with ARDS positive for SARS-CoV2 PCR were allocated to the COVID-19 group. Propensity score matching was performed for age, ECMO and risk of bleeding according to HAS-BLED score.Results: A total of 163, mostly severe ARDS patients were identified, 116 (71.2%) without COVID-19 and 47 (28.8%) positive for SARS-CoV-2. The two groups were comparable concerning the main confounders of ICH including age, HAS-BLED score, need for ECMO-therapy as well as anticoagulation levels reported. In 63/163 cases (38.7%), veno-venous ECMO therapy was required and ICU survival was 52.8%. Although HAS-BLED-score on admission was generally low (1.6±1.3), intracerebral hemorrhage was detected in 22 patients (13.5%) with no statistical difference between the groups (11.2 vs. 19.1% with and without SARS-CoV-2, respectively, p=0.21). Propensity score matching confirmed similar intracerebral bleeding rates in both groups (12.8 vs. 19.1% with and without SARS-CoV-2, respectively, p=0.57). Conclusions: Intracerebral hemorrhage was detectable in every tenth patient with ARDS. We found no statistically significant increased bleeding rate in patients with ARDS due to COVID-19 compared to other causes of ARDS.
Development of Two Wheeled Robot (TWR) by Single Stepper Driver Using PID Controller
Authors: Maheshbhai Vasvani Ashish , KUMAR DEEPAK , Sinha Ravi 
Published: August 2020

Abstract
The mechanical stability is an important parameter for the development of specific robots. Nowadays, it has turned into an essential region of research in the current development, due to increased applications of robots in various fields such as biomedical, aerospace, marines etc. In this paper, Two wheeled Robot (TWR) is designed and fabricated following the concept of an inverted pendulum. It balances itself up in the vertical position. The Proportional Integral Derivative (PID) controller was utilized to locate its stable transformed position. The developed two wheeled robot (TWR) was controlled using angle of pendulum (). It consists of two stepper motors, one arduino Nano microcontroller, Inertial Mass Unit (IMU) sensor and stepper motor driver. An IMU sensor comprises of 3-axis accelerometer and 3-axis gyroscope which measure acceleration and angular velocity. The angle of robot () with respect to the vertical position is computed from the mesaured data. It helps the wheel to prevent from fall by providing the acceleration according to its inclination () from the vertical position. Further, complementary filter was used to compensate gyro drifts with the help of accelerometer readings. PID constants were tuned until optimum values are achieved. Performances were compared with ardunio UNO based Self-Balancing Robot [20] & found that the performance of TWR is almost similar to ardunio UNO based Self-Balancing Robot.