bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forkhead box C1 promotes the pathology of osteoarthritis by upregulating β‐catenin in synovial fibroblasts
Authors: Wang Jun , Wang Yin , Zhang Hui , Gao Weilu , Lu Ming , Liu Wendong , Li Yetian , Yin Zongsheng 
Published: December 2019

Osteoarthritis (OA) is a joint disease characterized by articular cartilage degeneration, and no effective treatment is available. The OA classification has shifted from a cartilage‐only disease to a whole‐joint disease, and the synovial membrane plays an important role. Therefore, studies are needed to identify additional genes that regulate the pathological changes in the synovial membrane to develop a promising therapeutic strategy for OA. Here, we validated that the expression of forkhead box protein C1 (FoxC1) and β‐catenin was upregulated in OA synovial membranes and synovial fibroblasts (SFs). Gain‐ and loss‐of‐function studies revealed that FoxC1 overexpression promoted, whilst silencing inhibited OA synovial fibroblast (OASF) proliferation and pro‐inflammatory cytokine [interleukin 6 (IL‐6), interleukin 8 (IL‐8) and tumour necrosis factor‐α (TNF‐α)] production. FoxC1 overexpression increased β‐catenin mRNA, total and nuclear protein expression in OASFs and upregulated a disintegrin and metalloproteinase with thrombospondin motif 5 (ADAMTS‐5), fibronectin, matrix metalloproteinase 3 (MMP3) and matrix metalloproteinase 13 (MMP13) mRNA and total protein expression in OASFs. Conversely, FoxC1 knockdown reduced β‐catenin mRNA, total and nuclear protein expression in OASFs and reduced ADAMTS‐5, fibronectin, MMP3 and MMP13 mRNA and total protein expression in OASFs. β‐catenin mediates FoxC1‐induced pathological changes (proliferation, catabolic regulation and inflammation) in OASFs. MicroRNA‐200a‐3p (miR‐200a‐3p) binds to the 3′‐UTR of FoxC1 and mediates FoxC1 expression. Intra‐articular FoxC1‐specific siRNA transfection hindered OA development in mice. Therefore, our results demonstrate the key role FoxC1 plays in vivo and in vitro in OA synovial pathology, possibly identifying a potential novel therapeutic target for OA.
Intervention with erythropoietin in sarcopenic patients with femoral intertrochanteric fracture and its potential effects on postoperative rehabilitation
Authors: Zhang Yiou , Chen Li , Wu Peng , Lang Junzhe , Chen Lei 
Published: December 2019

AimTo explore the intervention with erythropoietin (EPO) in sarcopenic patients with femoral intertrochanteric fractures, and its potential effects on postoperative rehabilitation.MethodsA total of 141 patients with femoral intertrochanteric fracture were selected from January 2018 to January 2019. Patients (aged ≥60 years) with indications for EPO use, but without significant medical history, were selected in the present study. All patients were screened for sarcopenia, and divided into the intervention group and control group according to whether they took EPO. The intervention groups received EPO postoperatively every day for 10 days, whereas the control groups received an equal dose of normal saline. Patients' handgrip strength, appendicular skeletal muscle, duration of hospitalization and postoperative infection rate were assessed by analysis.ResultsAmong sarcopenic women, the handgrip strength was higher in the intervention group than in the control group after a week (P < 0.05). However, no significant effect was found in men (P > 0.05). The appendicular skeletal muscle increment of the intervention group with sarcopenia was markedly increased regardless of sex (P < 0.001). In addition, the postoperative infection rate was lower in the intervention group than the control group (P < 0.05), accompanied by a shorter hospital stay due to EPO administration (P < 0.05).ConclusionsEPO can improve the muscle strength of female patients with sarcopenia during the perioperative period, and increase muscle mass both of women and men. It can improve the symptoms of sarcopenia, but cannot reverse sarcopenia. Additionally, it can reduce the postoperative complications of patients with hip fracture and shorten the length of hospital stay. Therefore, postoperative administration of EPO might potentially promote rapid postoperative rehabilitation. Geriatr Gerontol Int 2020; 20: 150–155.
Mental health according to sleep duration in stroke survivors: A population‐based nationwide cross‐sectional study
Authors: Moon Hye‐Mi , Kim Yoonjung 
Published: December 2019

AimMany stroke survivors experience sleep disorders, and are at risk of severe depression and stress. This study examined the association between mental health and sleep duration among Korean stroke survivors.MethodsThis cross‐sectional study analyzed data from the Korea National Health and Nutrition Examination Surveys V (2010–2012) and VI (2013). The nationally representative sample included 504 adults aged ≥19 years.ResultsThe odds ratio for suicidal ideation was 2.71 (95% confidence interval 1.11–6.60) for stroke survivors who slept <5 h as compared with stroke survivors who slept between 6 and 8 h. Although stress and depression did not differ according to sleep duration, suicidal ideation did.ConclusionsSleep duration should be considered as a possible leverage point for preventing suicidal ideation among stroke survivors, and health promotion programs that promote and educate survivors about the importance of appropriate sleep duration are required. Geriatr Gerontol Int 2019; ••: ••–••.
Performance evaluation of three semantic expansions to query PubMed
Authors: Massonnaud Clément , Lelong Romain , Kerdelhué Gaétan , Lejeune Emeline , Grosjean Julien , Griffon Nicolas , Darmoni Stefan J. 
Published: December 2019

AbstractBackgroundPubMed is one of the most important basic tools to access medical literature. Semantic query expansion using synonyms can improve retrieval efficacy.ObjectiveThe objective was to evaluate the performance of three semantic query expansion strategies.MethodsQueries were built for forty MeSH descriptors using three semantic expansion strategies (MeSH synonyms, UMLS mappings, and mappings created by the CISMeF team), then sent to PubMed. To evaluate expansion performances for each query, the first twenty citations were selected, and their relevance were judged by three independent evaluators based on the title and abstract.ResultsQueries built with the UMLS expansion provided new citations with a slightly higher mean precision (74.19%) than with the CISMeF expansion (70.28%), although the difference was not significant. Inter‐rater agreement was 0.28. Results varied greatly depending on the descriptor selected.DiscussionThe number of citations retrieved by the three strategies and their precision varied greatly according to the descriptor. This heterogeneity could be explained by the quality of the synonyms. Optimal use of these different expansions would be through various combinations of UMLS and CISMeF intersections or unions.ConclusionInformation retrieval tools should propose different semantic expansions depending on the descriptor and the search objectives.
Vitrified and nonvitrified municipal solid wastes as ordinary Portland cement (OPC) and sand substitution in mortars
Authors: Sharifikolouei Elham , Canonico Fulvio , Salvo Milena , Baino Francesco , Ferraris Monica 
Published: December 2019

AbstractThis work aims to evaluate the potential suitability of nonvitrified and vitrified bottom ashes to serve as substitute materials for both OPC and sand in mortars on an industrial scale. Three bottom ashes were selected as OPC substitutes: one was vitrified inside the incinerator plant (W1‐C), one was carbonated under ambient conditions for 3 months (W2‐C), and part of the carbonated bottom ash was further washed with Ca(OH)2 (W2‐W‐C). Composition and phases of the bottom ash sources were assessed by XRF and XRD, respectively. Thereafter, mortars were prepared by replacing 10, 20 or 30 wt% of OPC with these bottom ashes. It was shown that even though Ca(OH)2 washing step (W2‐W‐C) led to an increment of the compressive strength in final mortars compared to the use of W2‐C, it failed to reach the mechanical performance of OPC. On the contrary, the use of vitrified bottom ashes (W1‐C) could lead to obtaining compressive strength comparable to that of standard mortar if added up to 10 wt%. Regarding the sand substitution, vitrified bottom ashes could reach suitable compressive strength when replacing 20 wt% of standard sand. The alkali aggregate reaction test confirmed the neutrality of substitution material added up to 50 wt%.
Can traffic light nutritional labels induce healthier consumer choices? Experimental evidence from a developing country
Authors: Defago Daniel , Geng José Fernando , Molina Oswaldo , Santa María Diego 
Published: December 2019

AbstractIn a context of increasing health problems related to bad dietary habits in developing countries, simplified nutritional label formats may be a promising policy alternative. The aim of this study is to assess whether the multiple traffic light (MTL) system can improve the nutritional quality of consumer decisions. We conducted a selection experiment in Peru, where participants were offered a choice between three alternatives in two different food categories (crackers and beverages). Individuals were randomly assigned products with MTL labels on them. Our results reveal that exposure to MTL labels significantly increases the probability of avoiding the least healthy options and of choosing the healthiest items among the alternatives provided. These effects are large in magnitude and seem to be driven by individuals that are female, report average or above average dietary habits, and lack basic nutritional knowledge. However, our findings also suggest that the effectiveness of MTL labels may be sensitive to the specific characteristics of the set of options provided. These findings contribute to the emerging experimental literature on MTL labels in two ways. First, we provide evidence that this system can be effective in inducing consumers to make healthier choices in real‐life situations. Second, we explore which individuals are more likely to benefit from exposure to MTL labels, as well as potential limitations to their effectiveness. Overall, our results provide new insights on how to assess the issue of bad nutrition in emerging economies.
Effect of season and proximate composition on the Br, As, Cd and Pb contents in different kinds of key foods consumed in Portugal
Authors: Ventura Marta , Cardoso Carlos , Bandarra Narcisa Maria , Delgado Inês , Coelho Inês , Gueifão Sandra , Martins Marta , Costa Maria Helena , Castanheira Isabel 
Published: December 2019

SummaryOn the basis of a Total Diet Study, the Br, As, Cd and Pb contents in relevant food groups consumed in Portugal were determined. The studied groups were meat products, fatty fish, lean fish, shellfish, cephalopods, fresh and dried fruit, crucifers and other vegetables. It was observed that the concentrations of As, Br, Cd and Pb in fruit, vegetables and meat products were much lower than in seafood. Fresh fruit exhibited the lowest elemental contents. The concentrations of As, Br, Cd and Pb did not show any dependence on season. With respect to proximate composition, elemental content dependence on protein or ash was weak. PCA showed relevant associations: between Br and ash contents in fatty fish; between Cd, Pb and protein contents in crucifers; and between As, fat and protein contents in the other vegetables group. Therefore, the effect of the proximate composition on the studied elemental contents warrants investigation.
Effects of processing and storage conditions on the stability of sweet potato (Ipomoea batatas L.) leaf flavonoids
Authors: Liu Jiang , Mu Taihua , Sun Hongnan , Fauconnier Marie Laure 
Published: December 2019

SummaryThe effect of heat, high hydrostatic pressure (HHP) treatment, pH, light, temperature and simulated digestion on sweet potato leaf flavonoids (SPLF) stability was studied. Results showed heat treatment at 75 °C for 90 min or HHP treatment at 600 MPa for 30 min did not cause significant effect on SPLF. Heat treatment at 100 °C for 60 min and 90 min led to decrease in antioxidant activity by 20% and 25%, respectively, while pH 7.0 and 8.0 significantly decreased amount of SPLF by approximately 75%, decreased antioxidant activity by about 30% and 47% separately. Light treated samples recorded a decrease in SPLF by 52% and antioxidant activity by 24%. No significant effect on SPLF was observed for samples stored at −18 °C, 4 °C or room temperature. The retention of flavonoids and antioxidant activity was 45.9 ± 3.6% and 56.2 ± 2.6%, individually in SPLF after simulated digestion.
Meeting report and review: Immunological assays and correlates of protection for next‐generation influenza vaccines
Authors: Krammer Florian , Weir Jerry P. , Engelhardt Othmar , Katz Jacqueline M. , Cox Rebecca Jane 
Published: December 2019

AbstractBackgroundThis report summarizes the discussions and conclusions from the “Immunological Assays and Correlates of Protection for Next‐Generation Influenza Vaccines” meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.ConclusionsFurthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.
Evaluating complications in below‐knee skin cancer surgery after introduction of preoperative appointments: A 2‐year retrospective cohort study
Authors: Lindholm Vivian M. , Isoherranen Kirsi M. , Schröder Marika T. , Pitkänen Sari T. 
Published: December 2019

AbstractBelow‐knee dermatological surgery has a high risk of complications such as wound infection, bleeding, and necrosis. In this study, we evaluated the impact of preoperative appointments on complication risks. We searched the medical records of the Helsinki University Central Hospital (HUS) Dermatosurgery unit for all below‐knee surgeries during 2016, when no preoperative nurse appointments were carried out, and compared it with 2018, when preoperative appointments for risk patients were introduced. The study included 187 patients in 2016 and 179 patients in 2018, of whom 68 (about one third) attended preoperative appointments. At the appointments, risk factors were evaluated, and compression therapy was introduced when possible. The results show complication rates of 13.4% in 2016 vs 10.1% in 2018 (P = .33), despite significantly higher risks in the 2018 patient group. The odds ratio for complications in appointment attendees vs non‐attendees was reduced after adjustments to 0.58; however, this was insignificant (P = .47). The odds of complications for skin grafts were considerably higher: 11.33 vs other surgery techniques (P = .00). In conclusion, the introduction of preoperative appointments appeared to reduce complications in below‐knee surgery. For graft reconstructions, complication risk is high, even with carefully planned pre‐ and postoperative care. Further studies are needed to evaluate preventable risk factors of below‐knee graft reconstructions.
Polyphasic characterization of Aspergillus section Flavi isolated from animal feeds in Algeria
Authors: Bouti Karima , Verheecke‐Vaessen Carol , Mokrane Salim , Meklat Atika , Djemouai Nadjette , Sabaou Nasserdine , Mathieu Florence , Riba Amar 
Published: December 2019

AbstractIn Algeria, little information is available on the population structure of Aspergillus section Flavi in raw materials and resultant animal feeds. A total of 172 isolates belonging to Aspergillus section Flavi were recovered from 57 animal feeds and identified on the basis of macro and micro‐morphological characters, mycotoxin production and genetic relatedness. For the molecular analysis, sequencing of the calmodulin gene (CaM) and the internal transcribed spacer (ITS) regions were performed for representative isolates. Four distinct morphotypes were distinguished: Aspergillus flavus (78.5%), Aspergillus tamarii (19.2%), Aspergillus parasiticus (1.7%), and Aspergillus alliaceus (0.6%). All A. flavus isolates were of the L type and no correlation between sclerotia production and aflatoxigenicity was observed. Our results showed that 68% of the A. flavus strains produced aflatoxins B (AFB), and 72.7% were cyclopiazonic acid (CPA) producers. The three isolates of A. parasiticus were able to produce AFB and aflatoxins G but not CPA whereas, all the strains of A. tamarii produced only CPA. The obtained results revealed the presence of different species of Aspergillus section Flavi, among which were aflatoxin producers. This study provides evidence useful for considerations in aflatoxin control strategies.
What Does “Couple” Mean in Couple Therapy Outcome Research? A Systematic Review of the Implicit and Explicit, Inclusion and Exclusion of Gender and Sexual Minority Individuals and Identities
Authors: Spengler Elliot S. , DeVore Elliott N. , Spengler Paul M. , Lee Nicholas A. 
Published: December 2019

This study systematically reviewed extant couple therapy outcome studies (k = 111) through December 2018 to evaluate for implicit or explicit, inclusion or exclusion of gender and/or sexual minority individuals and identities. We evaluated sampling, participant demographic reporting, and language used in each manuscript for any reference or consideration given to participants' sexual and/or gender identity. Results indicate that couples have been historically presumed to be heterosexual and cisgender male or female without reported assessment. More recent inclusion and consideration of sexual minority individuals is limited and absent for nonmonosexual and gender minority individuals. These findings are contextualized in supplementary analyses of other sociocultural characteristics (e.g., race, age, length together). Suggestions are provided for affirmative consideration of the plurality of individuals' sexual and gender identities. Implications are discussed for research, training and practice of couple therapy with sexual and/or gender minority couples.
Myelin uncompaction and axo‐glial detachment in chronic ataxic neuropathy with monospecific IgM antibody to ganglioside GD1b
Authors: Tagliapietra Matteo , Zanusso Gianluigi , Ferrari Sergio , Orlandi Riccardo , Bertolasi Laura , Cavallaro Tiziana , Monaco Salvatore 
Published: December 2019

AbstractTo describe clinical features, disease course, treatment response, and sural nerve biopsy findings in a patient with chronic sensory ataxic neuropathy, Binet stage A chronic lymphocytic leukemia, and monoclonal IgMλ paraprotein against ganglioside GD1b. During 9 months of hospitalization at two neurologic centers, the patient underwent serial neurologic examinations, neurophysiologic studies, imaging investigations, extensive laboratory work‐up, bone marrow, and sural nerve biopsies. The patient had a severe progressive sensory neuropathy accompanied by motor involvement, dysautonomia, and marked bulbar weakness with preserved ocular movements. Conduction studies were characterized by prolonged F‐wave minimal latencies, prolonged distal latencies, reduction of compound motor action potentials, and absence of sensory nerve action potentials. Sural nerve biopsy showed endoneurial edema, axonal degeneration, and regeneration, in the absence of cellular inflammation, macrophagic activation, and B‐lymphocyte infiltration; no IgM or complement deposition was detected. Myelinated fibers showed redundant/abnormally thickened myelin, myelin vacuolation, and frank intramyelinic edema with condensed axoplasm. Ultrastructural features included axo‐glial detachment, disruption of membrane integrity, and myelin uncompaction. This study shows that monospecific anti‐GD1b IgM paraprotein is associated with non‐inflammatory nerve damage. We suggest that the loss of myelin and axonal integrity reflects antibody‐induced disruption of membrane lipid rafts.
Advancing Theory with Review Articles
Authors: Post Corinne , Sarala Riikka , Gatrell Caroline , Prescott John E. 
Published: December 2019

AbstractReviewing a body of work presents unique opportunities for making a theoretical contribution. Review articles can make readers think theoretically differently about a given field or phenomenon. Yet, review articles that advance theory have been historically under‐represented inJournal of Management Studies.Accordingly, the purpose of this editorial is to propose a multi‐faceted approach for fashioning theoretical contributions in review articles, which we hope will inspire more authors to develop and submit innovative, original, and high‐quality theory‐building review articles. We argue that advancing theory with review articles requires an integrative and generative approach. We propose a non‐exhaustive set of avenues for developing theory with a review article: exposing emerging perspectives, analysing assumptions, clarifying constructs, establishing boundary conditions, testing new theory, theorizing with systems theory, and theorizing with mechanisms. As a journal,Journal of Management Studiesis a journal of ideas – new ideas; ideas drawn from reflections on extant theory and ideas with potential to change the way we understand and interpret theory. With this in mind, we think that advancing theory with review articles is an untapped source of new ideas.
Identity integration in people with acquired disabilities: A qualitative study
Authors: Adler Jonathan M. , Lakmazaheri Ava , O'Brien Eamon , Palmer Alison , Reid Micah , Tawes Elizabeth 
Published: December 2019

AbstractObjectiveThis qualitative investigation focused on identity integration in a sample of individuals who acquired physical disabilities in adulthood. It also argues for the importance and ethics of these methods in the broader field of scholarship on personality change following adversity.MethodThirteen adults participated in the study. Participants engaged in an expanded Life Story Interview wherein they narrated the story of their life, including a section devoted to their story of acquiring a physical disability. In addition, participants completed questionnaires concerning their psychological well‐being and maturity.ResultsWe identified two dimensions of narrative themes participants used in grappling with identity integration: one represented active processing of one's life experiences and the other represented the extent to which participants described their identity as wholly transformed by the experience of acquiring a disability. When overlaid, these dimensions yielded four narrative strategies titled: Adapters, Wanderers, Drifters, and Resisters. We also observed that Adapters seemed to have better psychological well‐being and maturity than the other groups.ConclusionsThis study offers a foundation for future scholarship on identity among people with disabilities. It also describes the contexts in which retrospective, qualitative methods are especially appropriate for research on personality change following adversity.