bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trade configurations in Asia: Assessing de facto and de jure regionalism
Authors: Gopalan Sasidaran , Nguyen Trieu Duong Luu , Rajan Ramkishen S. 
Published: November 2019

AbstractGiven the backdrop of significant uncertainties largely propelled by the ongoing trade spat between the United States and China, to what degree can the Asian region move forward in terms of de facto trade integration? Drawing on the new economic geography literature, this paper offers new insights into the literature on trade regionalism in Asia by empirically illustrating how Asian economies can tap into the regional market potential. Specifically, the paper examines the scope for further de facto integration among the Asian countries engaged in the negotiation for the Regional Comprehensive Economic Partnership (RCEP) Agreement by estimating foreign market potential (FMP) indices. To preview the main findings, the empirical analysis demonstrates that the share of intra‐regional trade in total RCEP trade flows and, consequently, the ratio between within‐ and outside‐RCEP trades are significantly lower than what they could potentially be. The paper makes a case that the enhancement of de jure integration among these economies through the RCEP must be accompanied by efforts to improve de facto integration.
Challenge to Collect Empirical Data for Human Reliability Analysis—Illustrated by the Difficulties in Collecting Empirical Data on the Performance-Shaping Factor Complexity
Authors: Laumann Karin , Skogstad Martin Rasmussen 
Published: November 2019

Abstract
This paper discusses the challenges with collecting positivistic empirical data (objective, observable, reliable, replicable, experimental, and true) in human reliability analysis (HRA), and illustrates it by presenting the difficulties in collecting empirical data on the performance-shaping factor (PSF) complexity. The PSF complexity was chosen to illustrate the difficulties with empirically collecting data because it is included in many HRA guidelines and it has been discussed as an important PSF to understand error rates in large accident scenarios. This paper discusses the challenges with collecting empirical data from a pure positivistic paradigm with experiments, as well as from literature reviews and data from event reports, training, and operations. The paper concludes that because of all the challenges with the positivistic empirical data collections methods in HRA, we should discuss whether experts' judgements could be a better approach to obtain HRA data and error rates. In a postpositivistic view, qualitative data or experts' judgments could also be looked at as empirical data if the data were collected in a systematic and transparent way.
Analysis and Estimation of Human Errors From Major Accident Investigation Reports
Authors: Morais Caroline , Moura Raphael , Beer Michael , Patelli Edoardo 
Published: November 2019

Abstract
Risk analyses require proper consideration and quantification of the interaction between humans, organization, and technology in high-hazard industries. Quantitative human reliability analysis approaches require the estimation of human error probabilities (HEPs), often obtained from human performance data on different tasks in specific contexts (also known as performance shaping factors (PSFs)). Data on human errors are often collected from simulated scenarios, near-misses report systems, and experts with operational knowledge. However, these techniques usually miss the realistic context where human errors occur. The present research proposes a realistic and innovative approach for estimating HEPs using data from major accident investigation reports. The approach is based on Bayesian Networks used to model the relationship between performance shaping factors and human errors. The proposed methodology allows minimizing the expert judgment of HEPs, by using a strategy that is able to accommodate the possibility of having no information to represent some conditional dependencies within some variables. Therefore, the approach increases the transparency about the uncertainties of the human error probability estimations. The approach also allows identifying the most influential performance shaping factors, supporting assessors to recommend improvements or extra controls in risk assessments. Formal verification and validation processes are also presented.
Thermal Management System Modeling and Simulation of a Full-Powered Fuel Cell Vehicle
Authors: Wang Yiping , Li Jing , Tao Qi , Bargal Mohamed H. S. , Yu Mengting , Yuan Xiaohong , Su Chuqi 
Published: November 2019

Abstract
Thermal management is an important factor in securing the safe and effective operation of a fuel cell vehicle (FCV). A parameterized stack model of a 100 kW proton exchange membrane fuel cell (PEMFC) is constructed by matlab/Simulink to design and asses the thermal management characteristics of a 100 kW full-powered FCV. The cooling components model, with parameters obtained by theoretical calculation based on the cooling requirement, is developed in the commercial solver GT-COOL. A thermal management simulation platform is constructed by coupling the stack model and cooling components. The accuracy of the modeling method for the stack is validated by comparing with the experimental data. The relationship between the operating temperature and output performance of the fuel cell stack is revealed based on the simulation model. The simulation results show that the operating temperature has a considerable influence on stack performance under high-current operation, and the inlet and outlet temperatures of the stack change nearly linearly with the increasing environmental temperature. The heat dissipation potential of the thermal management system under the high-load condition is also verified. The temperatures and coolant flow of core components, including the stack, DC/DC, air compressor, and driving motor, can meet the cooling requirements.
Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials
Authors:   Children of Eden Primary School, Straschil Ursula , Witmer Kathrin , Delves Michael J , Marks Stephen D , Baum Jake 
Published: November 2019

ObjectiveThe global impact of artemisinin-based combination therapies on malaria-associated mortality and their origins in ancient Chinese medicine has heightened interest in the natural discovery of future antimalarials.MethodsA double-blind study to identify potential ingredients with antimalarial activity from traditional remedies with reported antipyretic properties. Recipes of clear broths, passed down by tradition in families of diverse ethnic origin, were sourced by school children. Broths were then tested for their ability to arrest malaria parasite asexual growth or sexual stage development in vitro. Clear broth extract was incubated with in vitro cultures ofPlasmodium falciparumasexual or mature sexual stage cultures and assayed for parasite viability after 72 hours.ResultsOf the 56 broths tested, 5 were found to give >50% in vitro growth inhibition againstP. falciparumasexual blood stages, with 2 having comparable inhibition to that seen with dihydroartemisinin, a leading antimalarial. Four other broths were found to have >50% transmission blocking activity, preventing male parasite sexual stage development. After unblinding, two active broths were found to be from siblings from different classes, who had brought in the same vegetarian soup, demonstrating assay robustness.ConclusionsThis screening approach succeeded in finding broths with activity against malaria parasitein vitrogrowth, arising from complex vegetable and/or meat-based broths. This represented a successful child education exercise, in teaching about the interface between natural remedies, traditional medicine and evidence-based drug discovery.
Twenty-four-month outcomes of inflammatory choroidal neovascularisation treated with intravitreal anti-vascular endothelial growth factors: a comparison between two treatment regimens
Authors: Invernizzi Alessandro , Pichi Francesco , Symes Richard , Zagora Sophia , Agarwal Aniruddha Kishandutt , Nguyen Phuc , Erba Stefano , Xhepa Alba , De Simone Luca , Cimino Luca , Gillies Mark C , McCluskey Peter J 
Published: November 2019

Background and aimThere is still no established treatment regimen for eyes with inflammatory choroidal neovascularisation (iCNV) treated with intravitreal anti-vascular endothelial growth factor (VEGF) injections. This study compared the 24-month outcomes of two treatment regimens of anti-VEGF injections in eyes with iCNV.MethodsEyes with iCNV treated with anti-VEGF injections were divided into two groups: eyes treated with a loading phase of 3 monthly injections and then re-treated as needed (LOADING group) and eyes treated as needed from the beginning (PRN group). Visual acuity (VA), number of injections and iCNV recurrences at 24 months were compared between the groups.ResultsEighty-two eyes were included, 42 in the LOADING and 40 in the PRN group. Baseline VA (mean(SD)) was 57.3 (15.8) letters in the LOADING vs 60.7 (15.6) letters in the PRN group (p=0.32). The VA (mean (95% CI)) increased at 3 months (+14.8 (10.6 to 18.9) and +11.2 (6.4 to 16) letters in the LOADING and PRN group, respectively) and remained significantly higher than baseline over the entire follow-up in both groups (all p<0.001). At 24 months, there was no difference in VA between the LOADING and PRN group (72.3 (14.0) vs 74.7 (11.3) letters, p=0.36) but the LOADING group received significantly more injections (median (Q1–Q3)) than the PRN (4.5 (3–7) vs 2.5 (2–3.2), p<0.0001). The iCNV recurrences were similar in both groups.ConclusionsiCNV responded well to anti-VEGF with significant and sustained VA improvement. The loading phase did not confer any advantage in terms of outcomes. PRN regimen from the beginning was as effective as more intensive treatment.
Emergency department front-end split-flow experience: ‘physician in intake’
Authors: Michael Sean S , Bickley Daniel , Bookman Kelly , Zane Richard , Wiler Jennifer L 
Published: November 2019

BackgroundEmergency department (ED) crowding is a critical problem in the delivery of acute unscheduled care. Many causes are external to the ED, but antiquated operational traditions like triage also contribute. A physician intake model has been shown to be beneficial in a single-centre study, but whether this solution is generalisable is not clear. We aimed to characterise the current state of front-end intake models in a national sample of EDs and quantify their effects on throughput measures.MethodsWe performed a descriptive mixed-method analysis of ED process changes implemented by a cross section of self-selecting institutions who reported 2 years of demographic/operational data and structured process descriptions of any ‘new front-end processes to replace traditional nurse-based triage’.ResultsAmong 25 participating institutions, 19 (76%) provided data. While geographically diverse, most were urban, academic adult level 1 trauma centres. Thirteen (68%) reported implementing a new intake process. All were run by attending emergency physicians, and six (46%) also included advanced practice providers. Daily operating hours ranged from 8 to 16 (median 12, IQR 10.25–15.85), and the majority performed labs, imaging and medication administration and directly discharged patients. Considering each site’s before-and-after data as matched pairs, physician-driven intake was associated with mean decreases in arrival-to-provider time of 25 min (95% CI 13 to 37), ED length of stay 36 min (95% CI 12 to 59), and left before being seen rate 1.2% (95% CI 0.6% to 1.8%).ConclusionsIn this cross section of primarily academic EDs, implementing a physician-driven front-end intake process was feasible and associated with improvement in operational metrics.
Mental health of parents of children with a developmental disability in British Columbia, Canada
Authors: Marquis Sandra Maureen , McGrail Kimberlyn , Hayes Michael 
Published: November 2019

BackgroundThere is evidence in the literature that parents of children who have a developmental disability experience an increased risk of mental health problems.MethodsThis study used population-level administrative data from the Ministry of Health, British Columbia, Canada, to assess the mental health of parents of children who have a developmental disability compared with the mental health of parents of children who do not have a developmental disability. Population-level and individual explanatory variables available in the data were included in the models.ResultsAt a population level, the study found strong evidence that parents of children who have a developmental disability experience higher odds of depression or other mental health diagnoses compared with parents of children who do not have a developmental disability. Age of the parent at birth of the child, income and location of healthcare services were all associated with outcomes.ConclusionParents of children who have a developmental disability may be in need of programmes and services that support their mental health.
Effect of exercise referral schemes upon health and well-being: initial observational insights using individual patient data meta-analysis from the National Referral Database
Authors: Wade Matthew , Mann Steven , Copeland Rob J , Steele James 
Published: November 2019

ObjectivesTo examine if exercise referral schemes (ERSs) are associated with meaningful changes in health and well-being in a large cohort of individuals throughout England, Scotland, and Wales from the National Referral Database.MethodsData were obtained from 23 731 participants from 13 different ERSs lasting 6 weeks to 3 months. Changes from pre- to post-ERS in health and well-being outcomes were examined including body mass index (BMI), blood pressure (systolic (SBP) and diastolic (DBP)), resting heart rate (RHR), short Warwick Edinburgh Mental Wellbeing Scale (SWEMWBS), WHO Well-Being Index (WHO-5), Exercise Related Quality of Life scale (ERQoL), and Exercise Self-Efficacy Scale (ESES). Two-stage individual patient data meta-analysis was used to generate effect estimates.ResultsEstimates (95% CIs) revealed statistically significant changes occurred compared with point nulls for BMI (−0.55 kg.m2(−0.69 to −0.41)), SBP (−2.95 mmHg (−3.97 to −1.92)), SWEMWBS (2.99 pts (1.61 to 4.36)), WHO-5 (8.78 pts (6.84 to 10.63)), ERQoL (15.26 pts (4.71 to 25.82)), and ESES (2.58 pts (1.76 to 3.40)), but not RHR (0.22fc(−1.57 to 1.12)) or DBP (−0.93 mmHg (−1.51 to −0.35)). However, comparisons of estimates (95% CIs) against null intervals suggested the majority of outcomes may not improve meaningfully.ConclusionsWe considered whether meaningful health and well-being changes occur in people who are undergoing ERSs. These results demonstrate that, although many health and well-being outcomes improved, the changes did not achieve meaningful levels. This suggests the need to consider the implementation of ERSs more critically to discern how to maximise their effectiveness.
NAT black holes
Authors: Gürses Metin , Heydarzade Yaghoub , Şentürk Çetin 
Published: November 2019

AbstractWe study some physical properties of black holes in Null Aether Theory (NAT) – a vector-tensor theory of gravity. We first review the black hole solutions in NAT and then derive the first law of black hole thermodynamics. The temperature of the black holes depends on both the mass and the NAT “charge” of the black holes. The extreme cases where the temperature vanishes resemble the extreme Reissner–Nordström black holes. We also discuss the contribution of the NAT charge to the geodesics of massive and massless particles around the NAT black holes.
Analytical studies on the hoop conjecture in charged curved spacetimes
Authors: Peng Yan 
Published: November 2019

AbstractRecently, with numerical methods, Hod clarified the validity of Thorne hoop conjecture for spatially regular static charged fluid spheres, which were considered as counterexamples against the hoop conjecture. In this work, we provide an analytical proof on Thorne hoop conjecture in the spatially regular static charged fluid sphere spacetimes.
Predictions of α decay half-lives for even–even superheavy nuclei with 104 ≤ Z ≤ 128 based on two-potential approach within cluster-formation model
Authors: Liu Hong-Ming , Xu Jun-Yao , Deng Jun-Gang , He Biao , Li Xiao-Hua 
Published: November 2019

In this work, we systematically study the [Formula: see text] decay half-lives of 170 even–even nuclei with [Formula: see text] within the two-potential approach while the [Formula: see text] decay preformation factor [Formula: see text] is obtained by the cluster-formation model. The calculated results can well reproduce the experimental data. In addition, we extend this model to predict the [Formula: see text] decay half-lives of 64 even–even nuclei with [Formula: see text] whose [Formula: see text] decay is energetically allowed or observed but not yet quantified. For comparison, the two famous models i.e., SemFIS proposed by Poenaru et al. [Europhys. Lett. 77 (2007) 62001] and UDL proposed by Qi et al. [Phys. Rev. Lett. 103 (2009) 072501] are used. The predicted results of these models are basically consistent. At the same time, through analyzing the changing trend of [Formula: see text] decay energy [Formula: see text] of [Formula: see text] and 128 isotopes nuclei with the increasing of neutron number N and that of [Formula: see text] decay preformation factor [Formula: see text] of those isotopes even–even nuclei with the increasing of neutron number N, [Formula: see text] may be a new neutron magic number.
Biomass-Based Synthesis of Green and Biodegradable Molecularly Imprinted Membranes for Selective Recognition and Separation of Tetracycline
Authors: Xing Wendong , Wu Yilin , Lu Jian , Lin Xinyu , Yu Chao , Dong Zeqing , Yan Yongsheng , Li Chunxiang 
Published: November 2019

Aggravating environmental problems have driven the unprecedented development of sustainable materials. Treatments of environmental pollutants with biomass-based sustainable materials are catching attention of more researchers. In the present work, a biomass-based strategy was developed to prepare sustainable molecularly imprinted nanocomposite membranes (S-MINMs). Based on this strategy, biomass-activated carbon nanoparticles (ACNPs) as the porous filler were integrated into the porous cellulose acetate (CA)/chitosan (CS) hybrid membranes to synthesize renewable and easy degradable basal membranes. The specific recognition sites were fabricated from simple free radical polymerization method, and using methacrylic acid (MAA) and acrylamide (Am) as functional monomers, we obtain improved adsorption capacity on tetracycline (TC, template molecule). Performance of S-MINMs was evaluated by adsorption isotherm, adsorption kinetics, perm-selectivity, reusability and biodegradability. Results indicated that the as-prepared S-MINMs not only exhibited desirable biodegradability, but also possess superior adsorption and separation performance toward TC (15.99[Formula: see text]mg g[Formula: see text] for adsorption capacity and 4.91 for perms-selectivity factor). The method developed here shows great potential for development of sustainable membranes for selective separation of various pollutants.
Rhodamine B removal from aqueous solution by CT269DR resin: Static and dynamic study
Authors: Yang Jinbei , Yu Shuyue , Chen Wentao , Chen Yibing 
Published: November 2019

The adsorption of Rhodamine B onto CT269DR resin has been studied through static and dynamic experiments. The effects of shaking speed, resin dosage, and pH on adsorption were investigated by static experiments. The external mass transfer rate remains substantially unchanged when the shaking speed exceeds 160 r min−1. The optimal pH range is 5–8, and an increase of resin dosage can directly improve the percentage of removal of Rhodamine B. The equilibrium isotherm data of Rhodamine B on CT269DR resin fit the Langmuir adsorption isotherm well. The thermodynamics parameters, Δ H = 69.93 kJ mol−1, Δ S = 326.73 J mol−1 K−1, and Δ G < 0, demonstrate that the adsorption of Rhodamine B onto CT269DR resin is spontaneous and endothermic. The pseudo first-order kinetic model can be successfully used to represent the adsorption process and the activation energy is 25.7 kJ mol−1. The dynamic experiments show that the breakthrough point is advanced when the flow rate increases and the bed adsorption capacity increases with increasing temperature. Furthermore, the desorption using the solution of 2% NaOH is suitable for desorption and reusing process, and scanning electron microscope (SEM) and fourier transform infrared spectroscopy (FT-IR) analysis reveals that used resin has good wear resistance and chemical stability. The results confirm that CT269DR resin can be employed as an efficient adsorbent for the removal of Rhodamine B from wastewater.
Psychological support in end-of-life decision-making in neonatal intensive care units: Full population survey among neonatologists and neonatal nurses
Authors: Dombrecht Laure , Cohen Joachim , Cools Filip , Deliens Luc , Goossens Linde , Naulaers Gunnar , Beernaert Kim , Chambaere Kenneth , Laroche Sabrina , Theyskens Claire , Vandeputte Christine , Cornette Luc , Van de Broek Hilde 
Published: November 2019

Background: Moral distress and burnout related to end-of-life decisions in neonates is common in neonatologists and nurses working in neonatal intensive care units. Attention to their emotional burden and psychological support in research is lacking. Aim: To evaluate perceived psychological support in relation to end-of-life decisions of neonatologists and nurses working in Flemish neonatal intensive care units and to analyse whether or not this support is sufficient. Design/participants: A self-administered questionnaire was sent to all neonatologists and neonatal nurses of all eight Flemish neonatal intensive care units (Belgium) in May 2017. The response rate was 63% (52/83) for neonatologists and 46% (250/527) for nurses. Respondents indicated their level of agreement (5-point Likert-type scale) with seven statements regarding psychological support. Results: About 70% of neonatologists and nurses reported experiencing more stress than normal when confronted with an end-of-life decision; 86% of neonatologists feel supported by their colleagues when they make end-of-life decisions, 45% of nurses feel that the treating physician listens to their opinion when end-of-life decisions are made. About 60% of both neonatologists and nurses would like more psychological support offered by their department when confronted with end-of-life decisions, and 41% of neonatologists and 50% of nurses stated they did not have enough psychological support from their department when a patient died. Demographic groups did not differ in terms of perceived lack of sufficient support. Conclusion: Even though neonatal intensive care unit colleagues generally support each other in difficult end-of-life decisions, the psychological support provided by their department is currently not sufficient. Professional ad hoc counselling or standard debriefings could substantially improve this perceived lack of support.