bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal to optimize evaluation and treatment of Febrile infection‐related epilepsy syndrome (FIRES): A Report from FIRES workshop
Authors: Koh Sookyong , Wirrell Elaine , Vezzani Annamaria , Nabbout Rima , Muscal Eyal , Kaliakatsos Marios , Wickström Ronny , Riviello James J. , Brunklaus Andreas , Payne Eric , Valentin Antonio , Wells Elizabeth , Carpenter Jessica L. , Lee Kihyeong , Lai Yi‐Chen , Eschbach Krista , Press Craig A. , Gorman Mark , Stredny Coral M. , Roche William , Mangum Tara 
Published: November 2020

AbstractFebrile infection‐related epilepsy syndrome (FIRES) is a rare catastrophic epileptic encephalopathy that presents suddenly in otherwise normal children and young adults causing significant neurological disability, chronic epilepsy, and high rates of mortality. To suggest a therapy protocol to improve outcome of FIRES, workshops were held in conjunction with American Epilepsy Society annual meeting between 2017 and 2019. An international group of pediatric epileptologists, pediatric neurointensivists, rheumatologists and basic scientists with interest and expertise in FIRES convened to propose an algorithm for a standardized approach to the diagnosis and treatment of FIRES. The broad differential for refractory status epilepticus (RSE) should include FIRES, to allow empiric therapies to be started early in the clinical course. FIRES should be considered in all previously healthy patients older than two years of age who present with explosive onset of seizures rapidly progressing to RSE, following a febrile illness in the preceding two weeks. Once FIRES is suspected, early administrations of ketogenic diet and anakinra (the IL‐1 receptor antagonist that blocks biologic activity of IL‐1β) are recommended.
Efficacy and safety of adjunctive perampanel in patients with focal seizures or generalized tonic‐clonic seizures: Post hoc analysis of Phase II and Phase III double‐blind and open‐label extension studies in India
Authors: Mehndiratta Man M. , Gulhane Manoj , Jabeen Shaik A. , Patten Anna , Dash Amitabh , Malhotra Manoj 
Published: November 2020

AbstractObjectiveThis post hoc analysis assessed the efficacy and safety of adjunctive perampanel in patients (aged ≥ 12 years) with focal seizures (FS), with/without focal to bilateral tonic‐clonic seizures (FBTCS), or generalized tonic‐clonic seizures (GTCS) in India.MethodsCenters in India were identified from six double‐blind, randomized, Phase II and Phase III studies of adjunctive perampanel (2–12 mg/day) and their open‐label extensions (OLEx). Efficacy assessments included median percent change in seizure frequency per 28 days, 50% and 75% responder and seizure‐freedom rates. Treatment‐emergent adverse events (TEAEs) were monitored.ResultsOverall, 128 patients (placebo, n = 39; perampanel, n = 89) were included in the double‐blind Safety Analysis Set and 126 (FS, n = 113 [placebo, n = 32; perampanel, n = 81]; FBTCS, n = 35 [placebo, n = 14; perampanel, n = 21]; GTCS, n = 13 [placebo, n = 6; perampanel, n = 7]) comprised the Full Analysis Set. Median percent reductions in seizure frequency per 28 days for placebo vs perampanel for Indian patients were as follows: 34.8% vs 49.8% (FS; not significant [NS]) and 43.1% vs 60.5% (FBTCS; NS) at 4–12 mg/day, respectively, and −22.4% vs 8.2% (GTCS; NS) at 8 mg/day, respectively. Fifty‐percent responder rates were 37.5% vs 55.1% (FS; NS), 42.9% vs 60.0% (FBTCS; NS), and 16.7% vs 42.9% (GTCS; NS), respectively; seizure‐freedom rates were 0.0% vs 5.8%, 7.1% vs 10.0%, and 0.0% vs 14.3%, respectively (all NS). Overall, 110 patients entered OLEx studies (FS, n = 99; GTCS, n = 11). Perampanel was efficacious for up to four years for FS and FBTCS and two years for GTCS. Across double‐blind and OLEx studies, TEAEs occurred in 58.4% and 83.6% of Indian perampanel‐treated patients, respectively; dizziness was most common. Efficacy and safety outcomes were generally similar overall between Indian and non‐Indian patients.SignificanceThese data suggest adjunctive perampanel (up to 12 mg/day) may be a suitable anti‐seizure medication for patients (aged ≥ 12 years) with FS, with/without FBTCS, or GTCS in India.
Gene expression profile unveils diverse biological effect of serum vitamin D in Hodgkin's and diffuse large B‐cell lymphoma
Authors: Donati Benedetta , Ferrari Angela , Ruffini Alessia , Manzotti Gloria , Fragliasso Valentina , Merli Francesco , Zanelli Magda , Valli Riccardo , Luminari Stefano , Ciarrocchi Alessia 
Published: November 2020

AbstractThe primary function of 25(OH)Vitamin D (VitD) is to control calcium; however, recent evidence associated serum VitD deficiency to high aggressiveness and worse outcome in different type of malignancies including lymphomas, and the reasons of such effect are to be defined. In this study, we investigated the association of VitD blood levels with gene expression in a retrospective cohort of 181 lymphomas (104 diffuse large B‐cell lymphomas [DLBCLs] and 77 classical Hodgkin's lymphomas [cHLs]) of whom 116 with available gene expression profiles (52 DLBCLs and 64 cHLs, respectively). In DLBCL, VitD deficiency did not cause significant alteration in gene expression suggesting different mechanisms of action including a possible systemic effect or an effect on pharmacokinetics. By contrast, in cHLs, VitD deficiency induced profound changes in the transcriptional program leading to the NF‐κB‐mediated activation of stress‐protective and pro‐survival pathways. Coherently, VitD signaling defined by vitamin D Receptor (VDR) expression analysis, resulted highly activated in cHLs but not in DLBCLs. Even if preliminary, these data represent the first evidence of a direct role of VitD in the biology of cHL and suggest a multimodality and disease‐specific activity of this vitamin in lymphomas.
A δ18O and δ2H stable water isotope analysis of subalpine forest water sources under seasonal and hydrological stress in the Canadian Rocky Mountains
Authors: Langs Lindsey E. , Petrone Richard M. , Pomeroy John W. 
Published: November 2020

AbstractSubalpine forests are hydrologically important to the function and health of mountain basins. Identifying the specific water sources and the proportions used by subalpine forests is necessary to understand potential impacts to these forests under a changing climate. The recent “Two Water Worlds” hypothesis suggests that trees can favour tightly bound soil water instead of readily available free‐flowing soil water. Little is known about the specific sources of water used by subalpine trees Abies lasiocarpa (Subalpine fir) and Picea engelmannii (Engelmann spruce) in the Canadian Rocky Mountains. In this study, stable water isotope (δ18O and δ2H) samples were obtained from S. fir and Engelmann spruce trees at three points of the growing season in combination with water sources available at time of sampling (snow, vadose zone water, saturated zone water, precipitation). Using the Bayesian Mixing Model, MixSIAR, relative source water proportions were calculated. In the drought summer examined, there was a net loss of water via evapotranspiration from the system. Results highlighted the importance of tightly vadose zone, or bound soil water, to subalpine forests, providing insights of future health under sustained years of drought and net loss in summer growing seasons. This work builds upon concepts from the “Two Water Worlds” hypothesis, showing that subalpine trees can draw from different water sources depending on season and availability. In our case, water use was largely driven by a tension gradient within the soil allowing trees to utilize vadose zone water and saturated zone water at differing points of the growing season.
Depressive Anhedonia and Creative Self‐concepts, Behaviors, and Achievements
Authors: Silvia Paul J. , Eddington Kari M. , Harper Kelly L. , Burgin Chris J. , Kwapil Thomas R. 
Published: November 2020

AbstractIn the large literature on creativity and mental illness, relatively few studies have explored anhedonia—impairments in anticipating, seeking, and experiencing rewards. This project explored self‐reported creativity in a sample of adults who differed in depressive anhedonia, determined via face‐to‐face structured clinical interviews. Participants completed measures of everyday creativity (engaging in common creative behaviors and hobbies), creative self‐concepts (creative self‐efficacy, creative personal identity, and self‐rated creativity in different domains), and creative achievements. Compared to the control group (n = 52), people in the anhedonia group (n = 22) had significantly higher engagement in little‐c creative activities (medium effect size). Effect sizes for self‐rated creativity and creative achievement were either small or near‐zero. Taken together, the findings suggest that anhedonia deserves more attention in future research on motivational aspects of creativity.
New function of polysaccharide from Rubus chingii Hu: protective effect against ethyl carbamate induced cytotoxicity
Authors: Ke Huihui , Bao Tao , Chen Wei 
Published: November 2020

AbstractBACKGROUNDRubus chingii Hu is a widely cultivated fruit in China and has declared multiple bioactivities including antioxidative activity. Ethyl carbamate (EC), mostly found in fermented food and alcoholic beverages, is a recognized human carcinogen, and researchers have proposed the correlation between oxidative stress and its toxicity. This study acquired the polysaccharide from R. chingii (RP) and explored its effect on EC‐induced cytotoxicity using Caco‐2 cells as the cell model.RESULTSResults showed that RP exhibited protection against EC‐induced toxicity by repairing redox imbalance as indicative of mitigated mitochondrial membrane potential collapse, attenuated reactive oxygen species overproduction, and impeded glutathione depletion. Moreover, the structural features of RP were characterized and revealed that it was mainly constituted by galacturonic acid and arabinose, with an average molecular weight of 7.039 × 105 g mol−1.CONCLUSIONOverall, our results provided a new approach dealing with the toxicity caused by EC from the perspective of oxidative stress and described a new potential healthy value of R. chingii Hu, which could contribute to the development of a promising dietary supplement and functional food. © 2020 Society of Chemical Industry
The diverse functional genes of maize rhizosphere microbiota assessed using shotgun metagenomics
Authors: Akinola Saheed Adekunle , Ayangbenro Ayansina Segun , Babalola Olubukola Oluranti 
Published: November 2020

AbstractBackgroundThe geographical diversification in chemical, biological and physical properties of plant biospheres instigates heterogenicity in the proliferation of important soil microbiome. Controlling functions and structure of plant rhizosphere from a better understanding and prediction of a plantʼs immediate environment will help assess plant–microbe interplay, improve the productivity of plant ecosystems and improve plant response to adverse soil conditions. Here we characterized functional genes of the microbial community of maize rhizosphere using a culture‐independent method.ResultsOur metadata showed microbial genes involved in nitrogen fixation, phosphate solubilization, quorum sensing molecules, trehalose, siderophore production, phenazine biosynthesis protein, daunorubicin resistance, acetoin, 1‐aminocyclopropane‐1‐carboxylate deaminase, 4‐hydroxybenzoate, disease control and stress‐reducing genes (superoxidase dismutase, catalase, peroxidase, etc.). β‐Diversity showed that there is a highly significant difference between most of the genes mined from rhizosphere soil samples and surrounding soils.ConclusionsThe high relative abundance of stress‐reducing genes mined from this study showed that the sampling sites harbor not only important plant‐beneficial organisms but also a hotspot for developing bio‐fertilizers. Nevertheless, since most of these organisms are unculturable, mapping cultivation strategies for their growth could make them readily available as bio‐inoculants and possible biotechnological applications in the future. © 2020 Society of Chemical Industry
Generalized fractional integral operators on Orlicz–Hardy spaces
Authors: Arai Ryutaro , Nakai Eiichi , Sawano Yoshihiro 
Published: November 2020

AbstractThe generalized fractional integral operators are shown to be bounded from an Orlicz–Hardy space to another Orlicz–Hardy space , where Φ and Ψ are generalized Young functions. The result extends the boundedness of the usual fractional integral operator from to for and , which was proved by Stein and Weiss in 1960.
A high‐efficiency design for 5‐W 2.4/5.8 GHz concurrent dual‐band class‐E power amplifier
Authors: Nguyen Dang‐An , Seo Chulhun 
Published: November 2020

AbstractIn this letter, a distributed element‐based load network is proposed for designing a high‐efficiency dual‐band (DB) 5‐W Class‐E power amplifier (PA), at two widely spaced frequencies of 2.4 and 5.8 GHz. This network consists of two different stages. The first stage deploys a flexible network configuration with crossed transmission lines (TLINs) to provide concurrent DB fundamental matching in a closed‐form derivation, which transforms the standard resistance of 50 Ω directly to the optimal complex impedances. By tolerating the combination of the up‐side and down‐side TLINs, the size of the overall circuit as well as the implementation complexity are reduced. The second stage uses a DB TLIN‐based resonator preceded by a series 50 Ω stub to control the harmonic impedances without altering the fundamental impedances, ensuring high efficiency at the fundamental frequencies. The measured prototype shows highest power added efficiency (PAE) of around 62.9% and 61.7% with output power of about 39 and 35 dBm at 2.45 and 5.76 GHz, respectively.
Synthesis, properties, and molecular simulations of high‐barrier polyimide containing carbazole moiety and amide group in the main chain
Authors: Liu Yiwu , Tang Ao , Tan Jinghua , He Pan , Chen Chengliang , Wu Ding , Li Yuhui , Zhao Xianqing , Zhang Hailiang 
Published: November 2020

AbstractAn intrinsic high‐barrier polyimide (2,7‐CPAPPI) containing rigid planar carbazole moiety and amide group in main chain was prepared. The 2,7‐CPAPPI shows very attractive barrier performances, possessing water vapor transmission rate (WVTR) and oxygen transmission rate (OTR) low to 0.04 g m−2 day−1 and 0.11 cm3 m−2 day−1, respectively. Meanwhile, 2,7‐CPAPPI also displays exceptional thermal stability with a glass transition temperature (Tg) of 552°C and coefficient of thermal expansion (CTE) of 15.48 ppm/K. The barrier performances of 2,7‐CPAPPI are compared with those of a structural analog (2,7‐CPPI, containing only carbazole moiety in the main chain) and a typical polyimide (Kapton). The structure–barrier performances relationship was investigated by molecular simulations, wide angle X‐ray diffraction (WAXD), and positron annihilation lifetime spectroscopy (PALS). The results show that 2,7‐CPAPPI has more number of intermolecular hydrogen bonds among the three PIs, which leads to close chain packing and thereby high crystallinity, low free volume, and poor chains mobility. That is, the high crystallinity and low free volume of 2,7‐CPAPPI decrease the diffusion and solubility of gases. Meanwhile, the poor chains mobility further reduces the gases diffusion. The decreased diffusion and solubility of gases consequently promote the improvement of barrier properties for 2,7‐CPAPPI.
NOx synthesis by atmospheric‐pressure N2/O2 filamentary DBD plasma over water: Physicochemical mechanisms of plasma–liquid interactions
Authors: Roy Nepal C. , Pattyn Cédric , Remy Antoine , Maira Nicolas , Reniers François 
Published: November 2020

AbstractIn this study, an atmospheric‐pressure filamentary dielectric barrier discharge plasma is produced over a deionized (DI) water surface to study the physicochemical mechanisms of plasma–liquid surface interactions for NOx synthesis. The gas‐phase plasma diagnostics are performed using optical emission spectroscopy, Fourier‐transform infrared spectroscopy, and by recording voltage–current curves, and liquid‐phase species are analyzed using ion chromatography and UV−visible spectrophotometer. The investigations indicate that the reaction pathways for reactive oxygen and nitrogen species (H2O2, , ) formation in DI water depend on different experimental conditions. It is observed that the conversion of nitrites into nitrates is significantly influenced by reactive oxygen species. The energy yield for the total amount of NOx synthesized ranges from 1.3 × 10−4 to 3.4 × 10−3 mol/MJ.
LHC signals for KK graviton from an extended warped extra dimension
Authors: Agashe Kaustubh , Ekhterachian Majid , Kim Doojin , Sathyan Deepak 
Published: November 2020

Abstract
We analyze signals at the Large Hadron Collider (LHC) from production and decay of Kaluza-Klein (KK) gravitons in the context of “extended” warped extra-dimensional models, where the standard model (SM) Higgs and fermion fields are restricted to be in-between the usual ultraviolet/Planck brane and a ∼ O(10) TeV (new, “intermediate”) brane, whereas the SM gauge fields (and gravity) propagate further down to the ∼ O(TeV) infrared brane. Such a framework suppresses flavor violation stemming from KK particle effects, while keeping the KK gauge bosons and gravitons accessible to the LHC. We find that the signals from KK graviton are significantly different than in the standard warped model. This is because the usually dominant decay modes of KK gravitons into top quark, Higgs and longitudinal W/Z particles are suppressed by the above spatial separation between these two sets of particles, thus other decay channels are allowed to shine themselves. In particular, we focus on two novel decay channels of the KK graviton. The first one is the decay into a pair of radions, each of which decays (dominantly) into a pair of SM gluons, resulting in a resonant 4-jet final state consisting of two pairs of dijet resonance. On the other hand, if the radion is heavier and/or KK gluon is lighter, then the KK graviton mostly decays into a KK gluon and a SM gluon. The resulting KK gluon has a significant decay branching fraction into radion and SM gluon, thereby generating (again) a 4-jet signature, but with a different underlying event topology, i.e., featuring now three different resonances. We demonstrate that the High-Luminosity LHC (HL-LHC) has sensitivity to KK graviton of (up to) ∼ 4 TeV in both channels, in the specific model with only gluon field (and gravity) propagating in the extended bulk, whereas it is unlikely to have sensitivity in the standard dijet resonance search channel from KK graviton decay into two gluons.
Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling
Authors: Horioka Mizuho , Ceraudo Emilie , Lorenzen Emily , Sakmar Thomas P. , Huber Thomas 
Published: November 2020

AbstractMany G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency virus 1 (HIV-1), normally signals through the heterotrimeric G protein, Gi. However, CCR5 also exhibits G protein signaling bias and certain chemokine analogs can cause a switch to Gq pathways to induce Ca2+ signaling. We want to understand how much of the Ca2+ signaling from Gi-coupled receptors is due to G protein promiscuity and how much is due to transactivation and crosstalk with other receptors. We propose a possible mechanism underlying the apparent switching between different G protein signaling pathways. We show that chemokine-mediated Ca2+ flux in HEK293T cells expressing CCR5 can be primed and enhanced by ATP pretreatment. In addition, agonist-dependent lysosomal exocytosis results in the release of ATP to the extracellular milieu, which amplifies cellular signaling networks. ATP is quickly degraded via ADP and AMP to adenosine. ATP, ADP and adenosine activate different cell surface purinergic receptors. Endogenous Gq-coupled purinergic P2Y receptors amplify Ca2+ signaling and allow for Gi- and Gq-coupled receptor signaling pathways to converge. Associated secretory release of GPCR ligands, such as chemokines, opioids, and monoamines, should also lead to concomitant release of ATP with a synergistic effect on Ca2+ signaling. Our results suggest that crosstalk between ATP-activated purinergic receptors and other Gi-coupled GPCRs is an important cooperative mechanism to amplify the intracellular Ca2+ signaling response.
Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome
Authors: Geer Eliza B. , Salvatori Roberto , Elenkova Atanaska , Fleseriu Maria , Pivonello Rosario , Witek Przemyslaw , Feelders Richard A. , Bex Marie , Borresen Stina W. , Puglisi Soraya , Biller Beverly M. K. , Cohen Fredric , Pecori Giraldi Francesca 
Published: November 2020

Abstract
Purpose
The efficacy of levoketoconazole in treating hypercortisolism was demonstrated in an open-label phase 3 study (SONICS) of adults with endogenous Cushing’s syndrome (CS) and baseline mean urinary free cortisol (mUFC) ≥  1.5× ULN. Clinical signs and symptoms and patient-reported outcomes from the SONICS trial were evaluated in the current manuscript.

Methods
Patients titrated to an individualized therapeutic dose entered a 6-month maintenance phase. Secondary endpoints included investigator-graded clinical signs and symptoms of CS during the maintenance phase, and patient-reported quality of life (CushingQoL questionnaire) and depression symptoms (Beck Depression Inventory II [BDI-II]).

Results
Of 94 enrolled patients, 77 entered the maintenance phase following individualized dose titration. Significant mean improvements from baseline were noted at end of maintenance (Month 6) for acne, hirsutism (females only), and peripheral edema. These improvements were observed as early as Day 1 of maintenance for hirsutism (mean baseline score, 7.8; ∆ − 1.9; P < 0.0001), end of Month 1 for acne (mean baseline score, 2.8; ∆ − 1.2; P = 0.0481), and Month 4 for peripheral edema (mean baseline score, 1.0; ∆ − 0.5; P = 0.0052). Significant mean improvements from baseline were observed by Month 3 of maintenance for CushingQoL (mean baseline score, 44.3; ∆ + 6.9; P = 0.0018) and at Month 6 for BDI-II (mean baseline score, 17.1; ∆ − 4.3; P = 0.0043) scores. No significant mean improvement was identified in a composite score of 7 other clinical signs and symptoms.

Conclusions
Treatment with levoketoconazole was associated with sustained, meaningful improvements in QoL, depression, and certain clinical signs and symptoms characteristic of CS.
ClinialTrials.gov identifier: NCT01838551.
Improving Clairvoyant: reduction algorithm resilient to imbalanced process arrival patterns
Authors: Proficz Jerzy , Ocetkiewicz Krzysztof M. 
Published: November 2020

AbstractThe Clairvoyant algorithm proposed in “A novel MPI reduction algorithm resilient to imbalances in process arrival times” was analyzed, commented and improved. The comments concern handling certain edge cases in the original pseudocode and description, i.e., adding another state of a process, improved cache friendliness more precise complexity estimations and some other issues improving the robustness of the algorithm implementation. The proposed improvements include skipping of idle loop rounds, simplifying generation of the ready set and management of the state array and an about 90-fold reduction in memory usage. Finally an extension enabling process arrival times (PATs) prediction was added: an additional background thread used to exchange the data with the PAT estimations. The performed tests, with a dedicated mini-benchmark executed in an HPC environment, showed correctness and improved performance of the solution, with comparison to the original or other state-of-the-art algorithms.