bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity to Copper and Development of Culturing and Toxicity Test Procedures for the Antarctic Terrestrial Nematode Plectus murrayi
Authors: Brown Kathryn E. , Wasley Jane , King Catherine K. 
Published: November 2019

Abstract
Environmental quality guideline values and remediation targets, specific to Antarctic ecosystems, are required for the risk assessment and remediation of contaminated sites in Antarctica. Ecotoxicological testing with Antarctic soil organisms is fundamental in determining reliable contaminant effect threshold concentrations. The present study describes the development of optimal culturing techniques and aqueous toxicity test procedures for an endemic Antarctic soil nematode, Plectus murrayi, which lives within interstitial waters between soil particles. Toxicity tests were of extended duration to account for the species’ physiology and life-history characteristics. Plectus murrayi was sensitive to aqueous copper with a 50% effective concentration for egg-hatching success of 139 µg/L. Hatched juveniles that were first exposed to copper as eggs appeared to be less sensitive than those first exposed at the hatched J2 stage, indicating a potential protective effect of the egg. Sensitivity of juveniles to copper increased with exposure duration, with 50% lethal concentrations of 478 and 117 µg/L at 21 and 28 d, respectively. The present study describes new methods for the application of an environmentally relevant test species to the risk assessment of contaminants in Antarctic soil and provides the first estimates of sensitivity to a toxicant for an Antarctic terrestrial microinvertebrate. Environ Toxicol Chem 2020;39:482–491. © 2019 SETAC
Performance analysis of the service periods of IEEE 802.11ad MAC
Authors: Hemanth C. , Venkatesh T. G. 
Published: November 2019

AbstractToday, we witness an explosion in wireless networks that are accessed by high‐performance mobile devices running a wide variety of demanding applications. The IEEE 802.11ad is a standard targeted at meeting these design requirements. Analytical modeling and performance evaluation is a crucial step needed for the evolution of any standard. In this paper, we model the service periods (SPs) of the IEEE 802.11ad hybrid medium access control as a special case of periodically gated queueing system (PGQS) with Bernoulli scheduling. We first state and prove some basic theorems related to the probability generating functions of the PGQS. Using these results, we derive the average delay and the delay variations (jitter) of packets belonging to SP of IEEE 802.11ad. We show that as the arrival rates increases, the delay increases linearly until the critical arrival rate, and beyond that, it becomes unbounded. Further, a practical scheme for the admission control mechanism of 802.11ad is also presented. To validate the model, analytical results are compared with simulation results.
Warfare in an evolutionary perspective
Authors: Majolo Bonaventura 
Published: November 2019

AbstractThe importance of warfare for human evolution is hotly debated in anthropology. Some authors hypothesize that warfare emerged at least 200,000–100,000 years BP, was frequent, and significantly shaped human social evolution. Other authors claim that warfare is a recent phenomenon, linked to the emergence of agriculture, and mostly explained by cultural rather than evolutionary forces. Here I highlight and critically evaluate six controversial points on the evolutionary bases of warfare. I argue that cultural and evolutionary explanations on the emergence of warfare are not alternative but analyze biological diversity at two distinct levels. An evolved propensity to act aggressively toward outgroup individuals may emerge irrespective of whether warfare appeared early/late during human evolution. Finally, I argue that lethal violence and aggression toward outgroup individuals are two linked but distinct phenomena, and that war and peace are complementary and should not always be treated as two mutually exclusive behavioral responses.
The wavelet scaling approach to forecasting: Verification on a large set of Noisy data
Authors: Bruzda Joanna 
Published: November 2019

AbstractIn the paper, we undertake a detailed empirical verification of wavelet scaling as a forecasting method through its application to a large set of noisy data. The method consists of two steps. In the first, the data are smoothed with the help of wavelet estimators of stochastic signals based on the idea of scaling, and, in the second, an AR(I)MA model is built on the estimated signal. This procedure is compared with some alternative approaches encompassing exponential smoothing, moving average, AR(I)MA and regularized AR models. Special attention is given to the ways of treating boundary regions in the wavelet signal estimation and to the use of biased, weakly biased and unbiased estimators of the wavelet variance. According to a collection of popular forecast accuracy measures, when applied to noisy time series with a high level of noise, wavelet scaling is able to outperform the other forecasting procedures, although this conclusion applies mainly to longer time series and not uniformly across all the examined accuracy measures.
Effect of fermentation and dry roasting on the nutritional quality and sensory attributes of quinoa
Authors: Castro‐Alba Vanesa , Lazarte Claudia Eliana , Perez‐Rea Daysi , Sandberg Ann‐Sofie , Carlsson Nils‐Gunnar , Almgren Annette , Bergenståhl Björn , Granfeldt Yvonne 
Published: November 2019

AbstractBackgroundQuinoa is a pseudocereal with relatively high content of proteins and minerals that also contains mineral inhibitors such as phytate. The aim of the present study was to evaluate lactic acid fermentation and dry roasting on the nutritional quality and sensory attributes of quinoa. Various processes were evaluated, and quinoa grains were dry‐roasted, milled, and fermented, either with or without the addition of wheat phytase or activated quinoa phytase (added as back‐slop starter), for 10 hr. In other processes, raw quinoa flour was fermented for 10 hr or 4 hr and dry‐roasted. Hedonic sensory evaluation was then performed to evaluate the acceptability of the fermented flours prepared as porridges.ResultsThe combined dry roasting and fermentation processes significantly (p < .05) degraded phytate between 30% and 73% from initial content. The most effective process was fermentation of raw quinoa flour followed by dry roasting, which improved the estimated zinc and iron bioavailability. Particularly, estimated zinc bioavailability improved from low (Phy:Zn 25.4, Phy·Zn:Ca 295) to moderate (Phy:Zn 7.14, Phy·Zn:Ca 81.5). Phytate degradation was mainly attributed to the activation of endogenous phytase during fermentation. Dry roasting was effective in improving the sensory attributes of the fermented quinoa flour. Porridge made with raw quinoa flour fermented for 4 hr and dry‐roasted was more favorable to overall acceptability than that which was fermented for 10 hr and dry‐roasted.ConclusionFermentation of quinoa flour for 4 hr followed by dry roasting was successful in improving both nutritional and sensory attributes of the final product.
Highly Active Carbon Supported PtCu Electrocatalysts for PEMFCs by in situ Supercritical Deposition Coupled with Electrochemical Dealloying
Authors: Barim S. B. , Bozbag S. E. , Deljoo B. , Aindow M. , Erkey C. 
Published: November 2019

AbstractCarbon aerogel and Vulcan supported PtCu electrocatalysts were prepared using the simultaneous and sequential in situ supercritical deposition (SCD) method in supercritical CO2 followed by thermal annealing and electrochemical dealloying. Before dealloying, annealed electrocatalysts prepared by simultaneous SCD had a more uniform PtCu composition in PtCu nanoparticles whereas electrocatalysts prepared by sequential SCD led to PtCu nanoparticles with Cu enrichment on the surface. Upon dealloying, PtCu/CA electrocatalyst prepared by simultaneous SCD had an enhanced ESA of 159.4 m2 g−1 due to the synergistic effects of PtCu nanoparticle size and PtCu composition in nanoparticles. All dealloyed electrocatalysts had higher mass activities and PtCu/Vulcan electrocatalyst prepared by simultaneous SCD had the highest mass activity of 0.178 A mgPt−1 which was more than twice of the mass activity of commercial Pt/C. PtCu/Vulcan electrocatalyst prepared by sequential SCD showed a specific activity of 0.511 mA cm−2 which was 5 times higher than the specific activity of commercial Pt/C.
Mapping the neuroanatomical impact of very preterm birth across childhood
Authors: Vandewouw Marlee M. , Young Julia M. , Mossad Sarah I. , Sato Julie , Whyte Hilary A. E. , Shroff Manohar M. , Taylor Margot J. 
Published: November 2019

AbstractThose born very preterm (VPT; <32 weeks gestational age) have an increased risk in developing a wide range of cognitive deficits. In early‐to‐late childhood, brain structure has been shown to be altered in VPT compared to full‐term (FT) children; however, the results are inconsistent. The current study examined subcortical volumes, cortical thickness, and surface area in a large cohort of VPT and FT children aged 4–12 years. Structural magnetic resonance imaging (MRI) was obtained on 120 VPT and 146 FT children who returned up to three times, resulting in 176 VPT and 173 FT unique data points. For each participant, Corticometric Iterative Vertex‐based Estimation of Thickness was used to obtain global measurements of total brain, cortical grey and cortical white matter volumes, along with surface‐based measurements of cortical thickness and surface area, and Multiple Automatically Generated Templates (MAGeT) brain segmentation tool was used to segment the subcortical structures. To examine group differences and group–age interactions, mixed‐effects models were used (controlling for whole‐brain volume). We found few differences between the two groups in subcortical volumes. The VPT children showed increased cortical thickness in frontal, occipital and fusiform gyri and inferior pre–post–central areas, while thinning occurred in the midcingulate. Cortical thickness in occipital regions showed more rapid decreases with age in the VPT compared to the FT children. VPT children also showed both regional increases, particularly in the temporal lobe, and decreases in surface area. Our results indicate a delayed maturational trajectory in those born VPT.
Top‐down versus bottom‐up attention differentially modulate frontal–parietal connectivity
Authors: Bowling Jake T. , Friston Karl J. , Hopfinger Joseph B. 
Published: November 2019

AbstractThe moment‐to‐moment focus of our mind's eye results from a complex interplay of voluntary and involuntary influences on attention. Previous neuroimaging studies suggest that the brain networks of voluntary versus involuntary attention can be segregated into a frontal‐versus‐parietal or a dorsal‐versus‐ventral partition—although recent work suggests that the dorsal network may be involved in both bottom‐up and top‐down attention. Research with nonhuman primates has provided evidence that a key distinction between top‐down and bottom‐up attention may be the direction of connectivity between frontal and parietal areas. Whereas typical fMRI connectivity analyses cannot disambiguate the direction of connections, dynamic causal modeling (DCM) can model directionality. Using DCM, we provide new evidence that directed connections within the dorsal attention network are differentially modulated for voluntary versus involuntary attention. These results suggest that the intraparietal sulcus exerts a baseline inhibitory effect on the frontal eye fields that is strengthened during exogenous orienting and attenuated during endogenous orienting. Furthermore, the attenuation from endogenous attention occurs even with salient peripheral cues when those cues are known to be counter predictive. Thus, directed connectivity between frontal and parietal regions of the dorsal attention network is highly influenced by the type of attention that is engaged.
Impact of infection control measures on the related costs and the amount of broad‐spectrum antimicrobial agents used in a hospital: A time‐series analysis
Authors: Tachi Tomoya , Toda Yumi , Seko Takayuki , Noguchi Yoshihiro , Teramachi Hitomi 
Published: November 2019

SummaryHealth care–associated infections (HAIs) worsen patient prognoses and increase medical costs. Antimicrobial stewardship (AMS), which involves appropriate use of antimicrobial agents and antiseptics, may be beneficial for addressing the issue of HAIs. In hospitals, an infection control team (ICT) plays an important role on the appropriate use of antimicrobial agents and antiseptics based on AMS. We aimed to conduct a time‐series analysis of the efficacies of infection control measures in terms of related costs, amount of broad‐spectrum antimicrobial agents used (carbapenems and quinolones), and methicillin‐resistant Staphylococcus aureus (MRSA) detection rates. This retrospective cross‐sectional study included in‐hospital patients treated at a single institute between January 2012 and December 2015. The intervention start point (initiation of infection control measures) was January 2014. All survey items were subjected to segmented regression analysis using an autoregressive integrated moving average (ARIMA) model. Differences between pre‐intervention and postintervention levels and their trends were assessed, using a statistical significance cutoff of P < .05. The infection control costs demonstrated a significantly increasing trend, despite significant decreases in the amount of carbapenems used. Accordingly, the implementation of infection control measures was associated with increased costs, whereas carbapenem use decreased immediately after intervention. Postintervention levels, trends of quinolone use, or MRSA detection rates did not reveal significant changes. Although implementation of infection control measures induced gradual increases in related costs, these measures led to immediate reductions in carbapenem use. Our study findings will support the establishment of more effective and economical infection control measures.
Letter to the editor regarding “Hall current effect on the peristaltic motion of synovial nanofluid with magnetohydrodynamics” by Wahed M. Hasona
Authors: Mekheimer Kh. S. 
Published: November 2019

AbstractIn a recent work Wahed M. Hasona have analyzed the effects of Hall currents and magnetic field through a horizontal and asymmetric channel with peristaltic waves for a synovial nanofluid. The author aim was to extend some previous works. These comments has been prepared from the perspective point of view that the readers of the above mentioned paper may not be aware of the several potentially serious flawed analysis and typographical errors throughout that work. In the next few pages we will focus on some of these mistakes/typos clarifying that the obtained results should be reported as fabricated results that no one can rely upon. For this reason we wrote these comments to elaborate on some of these errors with suggested corrections for these errors to correct the literature and ensure its integrity. We first show that the mathematical formulation for the model used in this paper is not satisfactory. As a result, the obtained analytical and numerical results are inappropriate and do not match with any results for the peristaltic flow models.
Linking hydrologic signatures to hydrologic processes: A review
Authors: McMillan Hilary 
Published: November 2019

AbstractHydrologic signatures are metrics that quantify aspects of streamflow response. Linking signatures to underlying processes enables multiple applications, such as selecting hydrologic model structure, analysing hydrologic change, making predictions in ungauged basins, and classifying watershed function. However, many lists of hydrologic signatures are not process‐based, and knowledge about signature‐process links has been scattered among studies from experimental watersheds and model selection experiments. This review brings together those studies to catalogue more than 50 signatures representing evapotranspiration, snow storage and melt, permafrost, infiltration excess, saturation excess, groundwater, baseflow, connectivity, channel processes, partitioning, and human alteration. The review shows substantial variability in the number, type, and timescale of signatures available to represent each process. Many signatures provide information about groundwater storage, partitioning, and connectivity, whereas snow processes and human alteration are underrepresented. More signatures are related to the seasonal scale than the event timescale, and land surface processes (ET, snow, and overland flow) have no signatures at the event scale. There are limitations in some signatures that test for occurrence but cannot quantify processes, or are related to multiple processes, making automated analysis more difficult. This review will be valuable as a reference for hydrologists seeking to use streamflow records to investigate a particular hydrologic process or to conduct large‐sample analyses of patterns in hydrologic processes.
Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative
Authors: Ochs-Balcom Heather M , Hovey Kathleen M , Andrews Christopher , Cauley Jane A , Hale Lauren , Li Wenjun , Bea Jennifer W , Sarto Gloria E , Stefanick Marcia L , Stone Katie L , Watts Nelson B , Zaslavsky Oleg , Wactawski-Wende Jean 
Published: November 2019

ABSTRACT
Short sleep duration, recognized as a public health epidemic, is associated with adverse health conditions, yet little is known about the association between sleep and bone health. We tested the associations of usual sleep behavior and bone mineral density (BMD) and osteoporosis. In a sample of 11,084 postmenopausal women from the Women's Health Initiative (WHI; mean age 63.3 years, SD = 7.4), we performed a cross-sectional study of the association of self-reported usual hours of sleep and sleep quality (WHI Insomnia Rating Score) with whole body, total hip, femoral neck, and spine BMD using linear regression models. We also studied the association of sleep duration and quality with dual-energy X-ray absorptiometry (DXA)-defined low bone mass (T-score &lt; −2.5 to &lt;−1) and osteoporosis (T-score ≤ −2.5) using multinomial regression models. We adjusted for age, DXA machine, race, menopausal symptoms, education, smoking, physical activity, body mass index, alcohol use, physical function, and sleep medication use. In adjusted linear regression models, women who reported sleeping 5 hours or less per night had on average 0.012 to 0.018 g/cm2 significantly lower BMD at all four sites compared with women who reported sleeping 7 hours per night (reference). In adjusted multinomial models, women reporting 5 hours or less per night had higher odds of low bone mass and osteoporosis of the hip (odds ratio [OR] = 1.22; 95% confidence interval [CI] 1.03–1.45, and 1.63; 1.15–2.31, respectively). We observed a similar pattern for spine BMD, where women with 5 hours or less per night had higher odds of osteoporosis (adjusted OR = 1.28; 95% CI 1.02–1.60). Associations of sleep quality and DXA BMD failed to reach statistical significance. Short sleep duration was associated with lower BMD and higher risk of osteoporosis. Longitudinal studies are needed to confirm the cross-sectional effects of sleep duration on bone health and explore associated mechanisms. © 2019 American Society for Bone and Mineral Research.
Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis
Authors: Chu Linyang , Liu Xuqiang , He Zihao , Han Xuequan , Yan Mengning , Qu Xinhua , Li Xiaofeng , Yu Zhifeng 
Published: November 2019

ABSTRACT
Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP changes on OA progression in patients with osteoporotic OA (OP-OA) has not been reported, especially the potential association between subchondral bone and articular cartilage. Thus we investigated the alterations in the microstructure, biomechanical properties, and remodeling of subchondral bone as well as their association with cartilage damage in the hip joint of patients with OP-OA. Thirty-nine femoral head specimens were obtained from patients who underwent total hip arthroplasty (OA group, n = 19; OP-OA group, n = 20), and healthy specimens from cadaver donors were used (control group, n = 10). The microstructure and biomechanical properties of subchondral bone were evaluated by micro–computed tomography and micro–finite-element analysis. Histology, histomorphometric measurements, and immunohistochemistry were used to assess subchondral bone remodeling and cartilage damage. Linear regression analysis was performed to elucidate the relationship between subchondral bone and articular cartilage. In the subchondral bone of the OP-OA group, compared with that of the OA group, aberrant bone remodeling leads to an inferior microstructure and worsening biomechanical properties, potentially affecting transmission of loading stress from the cartilage to the subchondral bone, and then resulting in accelerated OA progression in patients with OP-OA. The results indicate that changes in subchondral bone could affect OA development and the improvement in subchondral bone with bone-metabolism agents may help mitigate OA progression when OP and OA coexist in the same patients. © 2019 American Society for Bone and Mineral Research.
An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia
Authors: Noda Hiroshi , Guo Jun , Khatri Ashok , Dean Thomas , Reyes Monica , Armanini Michael , Brooks Daniel J , Martins Janaina S , Schipani Ernestina , Bouxsein Mary L , Demay Marie B , Potts John T , Jüppner Harald , Gardella Thomas J 
Published: November 2019

ABSTRACT
Jansen's metaphyseal chondrodysplasia (JMC) is a rare disease of bone and mineral ion physiology that is caused by activating mutations in PTHR1. Ligand-independent signaling by the mutant receptors in cells of bone and kidney results in abnormal skeletal growth, excessive bone turnover, and chronic hypercalcemia and hyperphosphaturia. Clinical features further include short stature, limb deformities, nephrocalcinosis, and progressive losses in kidney function. There is no effective treatment option available for JMC. In previous cell-based assays, we found that certain N-terminally truncated PTH and PTHrP antagonist peptides function as inverse agonists and thus can reduce the high rates of basal cAMP signaling exhibited by the mutant PTHR1s of JMC in vitro. Here we explored whether one such inverse agonist ligand, [Leu11,dTrp12,Trp23,Tyr36]-PTHrP(7-36)NH2 (IA), can be effective in vivo and thus ameliorate the skeletal abnormalities that occur in transgenic mice expressing the PTHR1-H223R allele of JMC in osteoblastic cells via the collagen-1α1 promoter (C1HR mice). We observed that after 2 weeks of twice-daily injection and relative to vehicle controls, the IA analog resulted in significant improvements in key skeletal parameters that characterize the C1HR mice, because it reduced the excess trabecular bone mass, bone marrow fibrosis, and levels of bone turnover markers in blood and urine. The overall findings provide proof-of-concept support for the notion that inverse agonist ligands targeted to the mutant PTHR1 variants of JMC can have efficacy in vivo. Further studies of such PTHR1 ligand analogs could help open paths toward the first treatment option for this debilitating skeletal disorder. © 2019 American Society for Bone and Mineral Research.