bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Diabetes Questionnaire to add patients’ perspectives to diabetes care for adults with type 1 and type 2 diabetes: nationwide cross-sectional study of construct validity assessing associations with generic health-related quality of life and clinical variables
Authors: Svedbo Engström Maria , Leksell Janeth , Johansson Unn-Britt , Borg Sixten , Palaszewski Bo , Franzén Stefan , Gudbjörnsdottir Soffia , Eeg-Olofsson Katarina 
Published: November 2020

ObjectivesTo study evidence for construct validity, the aim was to describe the outcome from the recently developed Diabetes Questionnaire, assess the associations of that outcome with clinical variables and generic health-related quality of life, and study the sensitivity to differences between clinically relevant groups of glycaemic control in adults with type 1 and type 2 diabetes in a nation-wide setting.DesignCross-sectional survey.SettingSwedish diabetes care clinics connected to the National Diabetes Register (NDR).ParticipantsAmong 2479 adults with type 1 diabetes and 2469 with type 2 diabetes selected at random from the NDR, 1373 (55.4%) with type 1 and 1353 (54.8%) with type 2 diabetes chose to participate.Outcome measuresThe Diabetes Questionnaire, the generic 36-item Short Form version 2 (SF-36v2) health survey and clinical variables.ResultsRelated to the prespecified assumptions, supporting evidence for construct validity for the Diabetes Questionnaire was found. Supporting divergent validity, the statistically significant correlations with the clinical variables were few and weak. In relation to the SF-36v2 and in support of convergent validity, the strongest correlations were seen in the Diabetes Questionnaire scales General Well-being and Mood and Energy. In those scales, machine learning analyses showed that about 40%–45% of the variance was explained by the SF-36v2 results and clinical variables. In multiple regression analyses among three groups with differing levels of glycated haemoglobin adjusted for demographics, other risk factors, and diabetes complications, the high-risk group had, in support of sensitivity to clinically relevant groups, statistically significant lower scores than the well-controlled group in most Diabetes Questionnaire scales.ConclusionsThis nation-wide study shows that the Diabetes Questionnaire captures some generic health-related quality-of-life dimensions, in addition to adding diabetes-specific information not covered by the SF-36v2 and clinical variables. The Diabetes Questionnaire is also sensitive to differences between clinically relevant groups of glycaemic control.
Treatment of hypertension reduces cognitive decline in older adults: a systematic review and meta-analysis
Authors: Gupta Aditi , Perdomo Sophy , Billinger Sandra , Beddhu Srinivasan , Burns Jeffrey , Gronseth Gary 
Published: November 2020

ObjectivesTo systematically analyse the effect of pharmacological treatment of hypertension (HTN) on cognitive decline in older adults.MethodsRandomised, placebo-controlled trials with a prespecified quantitative outcome of cognition and a pharmacological intervention for at least 12 months to treat HTN in older adults (>60 years). Our primary outcome was change in cognition with pharmacological treatment of HTN. Standardised mean difference (SMD) was used to analyse different outcomes reported in the selected studies. We searched PubMed CENTRAL and the Cochrane Library from inception to 6 July 2020. Two independent reviewers assessed trial quality and extracted data. Internal and external validity of the studies was assessed.ResultsNine randomised controlled trials with 34 994 participants were included in the final analysis. The net SMD for change in cognition was −0.049 (CI: −0.078 to −0.019) indicating that treatment of HTN decreased cognitive decline. Heterogeneity was low with an I² of 6%.DiscussionCurrent evidence does not indicate worsening of cognition with treatment of HTN. Treatment of HTN in older adults may reduce cognitive decline. These results have important implications in clinical management of patients at risk for dementia.PROSPERO registration numberCRD42020139750.
Diet and exercise interventions for individuals at risk for type 2 diabetes: a scoping review protocol
Authors: MacPherson Megan , Cranston Kaela , Locke Sean , Vis-Dunbar Mathew , Jung Mary E 
Published: November 2020

IntroductionGlobal rates of type 2 diabetes (T2D) are on the rise and there is a need for both effective and replicable interventions to decrease this incidence. Systematic reviews highlight the efficacy of diet and exercise interventions in decreasing T2D risk; however, no review to date provides clear information regarding intervention details (eg, what is delivered, by whom, to whom, when, and mode of delivery). This paper outlines the protocol for a scoping review summarising intervention characteristics of diet and exercise programmes for individuals at risk for T2D. From the included studies and through the use of the Template for Intervention Description and Replication (TIDieR), the scoping review that results from this protocol paper will provide a narrative analysis of how diabetes prevention programmes are being reported and implemented.MethodsA comprehensive search strategy is outlined to identify studies within Medline, CINAHL, PsycINFO, EMBASE and SPORTDiscus. The search strategy will include terms relating to diet and exercise interventions and diabetes risk. To determine eligible studies, predefined inclusion and exclusion criteria will be used independently by two review authors. To be included, studies must be delivering a diet and/or exercise intervention among adults who have been identified as at risk for developing T2D with an outcome related to diabetes prevention. Data extraction of those studies that meet inclusion criteria will be guided by the TIDieR).Ethics and disseminationEthical approval is not required as this review will be using previously collected data. Review findings will be presented at scientific conferences and published in a peer-reviewed journal.
Value of social network analysis for developing and evaluating complex healthcare interventions: a scoping review
Authors: Smit Linda C , Dikken Jeroen , Schuurmans Marieke J , de Wit Niek J , Bleijenberg Nienke 
Published: November 2020

ObjectivesMost complex healthcare interventions target a network of healthcare professionals. Social network analysis (SNA) is a powerful technique to study how social relationships within a network are established and evolve. We identified in which phases of complex healthcare intervention research SNA is used and the value of SNA for developing and evaluating complex healthcare interventions.MethodsA scoping review was conducted using the Arksey and O’Malley methodological framework. We included complex healthcare intervention studies using SNA to identify the study characteristics, level of complexity of the healthcare interventions, reported strengths and limitations, and reported implications of SNA. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews 2018 was used to guide the reporting.ResultsAmong 2466 identified studies, 40 studies were selected for analysis. At first, the results showed that SNA seems underused in evaluating complex intervention research. Second, SNA was not used in the development phase of the included studies. Third, the reported implications in the evaluation and implementation phase reflect the value of SNA in addressing the implementation and population complexity. Fourth, pathway complexity and contextual complexity of the included interventions were unclear or unable to access. Fifth, the use of a mixed methods approach was reported as a strength, as the combination and integration of a quantitative and qualitative method clearly establishes the results.ConclusionSNA is a widely applicable method that can be used in different phases of complex intervention research. SNA can be of value to disentangle and address the level of complexity of complex healthcare interventions. Furthermore, the routine use of SNA within a mixed method approach could yield actionable insights that would be useful in the transactional context of complex interventions.
Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: cross-sectional study
Authors: Chen Miaomiao , Liu Xiyao , Zhang Jun , Sun Guoqiang , Gao Ying , Shi Yuan , Baker Philip , Zeng Jing , Zheng Yangxi , Luo Xin , Qi Hongbo 
Published: November 2020

ObjectivesThis study described the needs of pregnant women and the contents of online obstetric consultation in representative areas with various severity of the epidemic in China.DesignThis was a cross- sectional study.SettingYue Yi Tong (YYT), a free online communication platform that allows pregnant women to consult professional obstetricians.ParticipantsAll the pregnant women who used the YYT platform.InterventionFrom 10 to 23 February, we collected data on online obstetric consultations and participants’ satisfaction through the YYT platform in the mild, moderate and severe epidemic areas which were defined according to the local confirmed cases. The primary outcomes were the reasons for online consultations by the severity of the epidemic. All the comparisons were performed using χ2 test. Statistical analysis was performed using SPSS V.24.ResultsA total of 2599 pregnant women participated in this study, of whom 448 (17.24%), 1332 (51.25%) and 819 (31.51%) were from the mild, moderate and severe epidemic areas, respectively. The distribution of the amount of online consultations was significantly different not only in different areas (p<0.001) but also in different trimesters (p<0.001). A total of 957 participants completed the satisfaction part of the survey. In this study, 77.95% of the participants used e-health for the first time, and 94.63% of the participants were completely or mostly satisfied with the online consultations.ConclusionsThe distribution of the amount of online consultations was significantly different not only in different areas but also in different trimesters. In any trimester, the amount of consultations on the second category (obstetric care-seeking behaviour) was the highest in the severe epidemic areas. The needs for online consultations were substantial. In order to prevent irreversible obstetric adverse events, an appropriate antenatal care contingency plan with e-health services is highly recommended during the Public Health Emergency of International Concern.
Designed electrochemical sensor based on metallocene modified conducting polymer composite for effective determination of tramadol in real samples
Authors: Atta Nada F. , Abdo Ghada G. , Elzatahry Ahmed , Galal Ahmed , Hassan Samar H. 
Published: November 2020

A novel composite for the electrochemical sensing of tramadol (Tr) was developed by the inclusion of a metallocene mediator between two layers of conducting poly(3,4-ethylenedioxythiophene) (PEDOT) polymer, in the presence of sodium dodecyl sulfate (SDS), i.e., P/mediator/P⋯SDS. Three charge transfer mediators were evaluated: ferrocene carboxylic acid (FC1), ferrocene (FC2), and cobaltocene (CC) for Tr electrocatalytic oxidation. The FC1 charge mediator showed a relatively higher current response that was assisted by the electronic conduction of the polymer film. Moreover, SDS presented a great impact, resulting in the enhancement of the preconcentration and (or) accumulation of Tr ions at the interface, leading to faster electron transfer. In addition, the practical application of the proposed FC1 composite for the determination of Tr in real urine and serum samples was successfully achieved with adequate recovery results. Very low detection limits of 18.6 nM and 16 nM in the linear dynamic ranges of 7–300 µM and 5–280 µM, respectively, were obtained at the proposed sensor. Furthermore, the simultaneous determination of Tr with common interfering species, paracetamol (APAP), morphine (MO), dopamine (DA), ascorbic acid (AA) and uric acid (UA), proved excellent, with good resolution and large potential peaks separation. The excellent characteristics of the proposed composite such as high reproducibility, good sensitivity, selectivity, anti-interference ability, and good stability enhanced its application for determination of other narcotic drugs.
Lifetimes of core-excited states in semi-magic $$^{95}\mathrm {Rh}$$
Authors: Ertoprak A. , Qi C. , Cederwall B. , Doncel M. , Jakobsson U. , Nyakó B. M. , Jaworski G. , Davies P. , de France G. , Kuti I. , Napoli D. R. , Wadsworth R. , Ghugre S. S. , Raut R. , Akkus B. , Al Azri H. , Algora A. , de Angelis G. , Atac A. , Bäck T. , Boso A. , Clément E. , Debenham D. M. , Dombrádi Zs. , Ertürk S. , Gadea A. , Ghazi Moradi F. , Gottardo A. , Hüyük T. , Ideguchi E. , Li H. , Michelagnoli C. , Modamio V. , Nyberg J. , Palacz M. , Petrache C. M. , Recchia F. , Sandzelius M. , Siciliano M. , Sohler D. , Timár J. , Valiente-Dobón J. J. , Xiao Z. G. 
Published: November 2020

AbstractLifetimes of negative-parity states have been determined in the neutron deficient semi-magic (N = 50) nucleus $$^{95}\mathrm {Rh}$$

95

Rh

. The fusion-evaporation reaction $$^{58}Ni(^{40}Ca, 3p)$$

58

N
i

(
40

C
a
,
3
p
)

was used to populate high-spin states in $$^{95}\mathrm {Rh}$$

95

Rh

at the Grand Accélérateur National d’Ions Lourds (GANIL) accelerator facility. The results were obtained using the Doppler Shift Attenuation Method (DSAM) based on the Doppler broadened line shapes produced during the slowing down process of the residual nuclei in a thick $$6\;\mathrm {mg/cm}^2$$

6

mg
/
cm

2

metallic target. B(M1) and B(E2) reduced transition strengths are compared with predictions from large-scale shell-model calculations.
Temperature effects on light yield and pulse shape discrimination capability of siloxane based scintillators
Authors: Carturan S. M. , Pino F. , Fontana C. L. , Moretto S. , Zanazzi E. , Raggio R. , Raniero W. , Quaranta A. 
Published: November 2020

AbstractIn this work, we report the study of temperature effects on light yield of siloxane-based scintillators and on n/$$\gamma $$
γ
discrimination capability, in terms of pulse shape discrimination (PSD). The solid scintillators are composed of phenyl containing polysiloxane (PMPS100), as a base polymer, loaded with moderate amounts (6 wt%) of 2,5-diphenyloxazole (PPO) as a primary dye and Lumogen Violet (LV) as waveshifter. The samples were heated in the range of 60–150 $$^\circ \hbox {C}$$

∘

C

and scintillation performance were tested both after annealing for 24 h and in real time during heating. Light yield of siloxane-based scintillators containing 6 wt% PPO heated at 100 $$^\circ \hbox {C}$$

∘

C

is very close to the room-temperature value, while heating at 120 $$^\circ \hbox {C}$$

∘

C

causes a decrease of light yield (LY) of 17%. In addition, the figure of merit (FoM) for n/$$\gamma $$
γ
discrimination of the scintillator shows a sensible worsening of the discrimination performances in case of prolonged treatment at 120 $$^\circ \hbox {C}$$

∘

C

. Similar tests are made using the commercial plastic scintillator EJ-299 (currently named EJ-276), based on polyvinyltoluene (PVT). In this case, the light yield undergoes a much more rapid deterioration with annealing temperature, and at 70 $$^\circ \hbox {C}$$

∘

C

it is reduced to 60% of the original value. The discrimination capability of EJ-299 decreases upon heating at 70 $$^\circ \hbox {C}$$

∘

C

as well, with a 20% reduction of FoM; meanwhile for T > 70 $$^\circ \hbox {C}$$

∘

C

the mechanical and optical features are remarkably degraded. The mass loss of primary dye PPO from the siloxane scintillator as a function of treatment temperature and initial dye concentration has been evaluated and compared to the behaviour of EJ-299. This measurement allows to single out and characterize a series of processes occurring during heating, which are relevant to the whole performance of the system under study, such as sublimation at the interface, thermally induced photooxidation of components, diffusion of fluorophores from the polymer bulk to the surface. The variation in luminescence characteristics have been analyzed by excitation/fluorescence spectroscopy and time-resolved fluorescence spectroscopy, in order to correlate the annealing treatment with the primary dye loss by sublimation, formation of superficial aggregates and/or degradation of the scintillator components in the synthesized siloxane scintillator.
Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Authors: Greve Gabriele , Schüler Julia , Grüning Björn A. , Berberich Bettina , Stomper Julia , Zimmer Dennis , Gutenkunst Lea , Bönisch Ulrike , Meier Ruth , Blagitko-Dorfs Nadja , Grishina Olga , Pfeifer Dietmar , Weichenhan Dieter , Plass Christoph , Lübbert Michael 
Published: November 2020

Abstract

Hypomethylating agents (HMA) have become the backbone of nonintensive acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) treatment, also by virtue of their activity in patients with adverse genetics, for example, monosomal karyotypes, often with losses on chromosome 7, 5, or 17. No comparable activity is observed with cytarabine, a cytidine analogue without DNA-hypomethylating properties. As evidence exists for compounding hypermethylation and gene silencing of hemizygous tumor suppressor genes (TSG), we thus hypothesized that this effect may preferentially be reversed by the HMAs decitabine and azacitidine. An unbiased RNA-sequencing approach was developed to interrogate decitabine-induced transcriptome changes in AML cell lines with or without a deletion of chromosomes 7q, 5q or 17p. HMA treatment preferentially upregulated several hemizygous TSG in this genomic region, significantly derepressing endogenous retrovirus (ERV)3–1, with promoter demethylation, enhanced chromatin accessibility, and increased H3K4me3 levels. Decitabine globally reactivated multiple transposable elements, with activation of the dsRNA sensor RIG-I and interferon regulatory factor (IRF)7. Induction of ERV3–1 and RIG-I mRNA was also observed during decitabine treatment in vivo in serially sorted peripheral blood AML blasts. In patient-derived monosomal karyotype AML murine xenografts, decitabine treatment resulted in superior survival rates compared with cytarabine. Collectively, these data demonstrate preferential gene derepression and ERV reactivation in AML with chromosomal deletions, providing a mechanistic explanation that supports the clinical observation of superiority of HMA over cytarabine in this difficult-to-treat patient group.

Significance:
These findings unravel the molecular mechanism underlying the intriguing clinical activity of HMAs in AML/MDS patients with chromosome 7 deletions and other monosomal karyotypes.
See related commentary by O'Hagan et al., p. 813
Neratinib-Plus-Cetuximab in Quadruple-WT (KRAS, NRAS, BRAF, PIK3CA) Metastatic Colorectal Cancer Resistant to Cetuximab or Panitumumab: NSABP FC-7, A Phase Ib Study
Authors: Jacobs Samuel A. , Lee James J. , George Thomas J. , Wade James L. , Stella Philip J. , Wang Ding , Sama Ashwin R. , Piette Fanny , Pogue-Geile Katherine L. , Kim Rim S. , Gavin Patrick G. , Lipchik Corey , Feng Huichen , Wang Ying , Finnigan Melanie , Kiesel Brian F. , Beumer Jan H. , Wolmark Norman , Lucas Peter C. , Allegra Carmen J. , Srinivasan Ashok 
Published: November 2020

Abstract

Purpose:
In metastatic colorectal cancer (mCRC), HER2 (ERBB2) gene amplification is implicated in anti-EGFR therapy resistance. We sought to determine the recommended phase II dose (RP2D) and efficacy of neratinib, a pan-ERBB kinase inhibitor, combined with cetuximab, in patients with progressive disease (PD) on anti-EGFR treatment.

Patients and Methods:
Twenty-one patients with quadruple-wild-type, refractory mCRC enrolled in this 3+3 phase Ib study. Standard dosage cetuximab was administered with neratinib at 120 mg, 160 mg, 200 mg, and 240 mg/day orally in 28-day cycles. Samples were collected for molecular and pharmacokinetic studies.

Results:
Sixteen patients were evaluable for dose-limiting toxicity (DLT). 240 mg was determined to be the RP2D wherein a single DLT occurred (1/7 patients). Treatment-related DLTs were not seen at lower doses. Best response was stable disease (SD) in 7 of 16 (44%) patients. HER2 amplification (chromogenic in situ IHC) was detected in 2 of 21 (9.5%) treatment-naïve tumors and 4 of 16 (25%) biopsies upon trial enrollment (post-anti-EGFR treatment and progression). Compared with matched enrollment biopsies, 6 of 8 (75%) blood samples showed concordance for HER2 CNV in circulating cell-free DNA. Five SD patients had HER2 amplification in either treatment-naïve or enrollment biopsies. Examination of gene-expression, total protein, and protein phosphorylation levels showed relative upregulation of ≥2 members of the HER-family receptors or ligands upon enrollment versus matched treatment-naïve samples.

Conclusions:
The RP2D of neratinib in this combination was 240 mg/day, which was well tolerated with low incidence of G3 AEs. There were no objective responses; SD was seen at all neratinib doses. HER2 amplification, detectable in both tissue and blood, was more frequent post-anti-EGFR therapy.
Avaliação do alinhamento articular dinâmico dos membros inferiores e a relação com lesões e performance em patinadores
Authors: Cabral Mariana Carolina Maciel , Schmit Emanuelle Francine Detogni , Candotti Cláudia Tarragô 
Published: November 2020

O objetivo deste estudo foi analisar o alinhamento articular dinâmico dos membros inferiores de patinadores artísticos sobre rodas e verificar a relação com o histórico de lesões e performance. Foram avaliadas 31 patinadoras (15,7±4,8 anos; 8,2±4,4 anos de prática da modalidade), acerca do alinhamento articular dinâmico dos membros inferiores (instrumento MADAAMI-P), do histórico de lesões e da performance (questionário). As análises estatísticas descritivas (média, desvio padrão, frequências) e inferenciais (teste de Shapiro-Wilk, correlação de Pearson/Spearman, teste t dependente/Wilcoxon, alpha=0,05) foram realizadas no software SPSS v. 20.0. Os resultados indicam que o início da fase competitivase dá por volta dos nove anos (9,1±3,1 anos), na frequência de quatro treinos semanais (4,4±0,7 treinos/semana), com ampla quantidade de medalhas obtidas no último ano (n=231). Quanto às lesões em membros inferiores, estas totalizaram 28, e os principais acometimentos envolveram joelho (n=09) e tornozelo (n=08), comumente relacionados à distensão e/ou estiramento (n=07). O alinhamento articular dinâmico dos membros inferiores foi de bom a excelente (escore mínimo de 53 e máximo de 99%). As correlações entre o alinhamento articular dinâmico dos membros inferiores com o histórico de lesões e com a performance não foram estatisticamente significativas, tanto quando avaliado o movimentode flexão, como quando o de semiflexão de joelhos, seja em relação ao alinhamento do arco do pé, do joelho ou da pelve. Conclui-se que o alinhamento articular dinâmico dos membros inferiores não é determinante de lesões na patinação nem de baixo desempenho na modalidade.
Leituras da relação entre cultura e Educação Física
Authors: Lara Larissa Michelle , Starepravo Fernando Augusto , Souza Vânia de Fátima Matias de , Miranda Antonio Carlos Monteiro de 
Published: November 2020

O presente artigo discute a relação entre cultura e Educação Física nos contextos argentino, chileno e colombiano por meio da colaboração de professores-pesquisadores a partir do envio de questionários. Adensam esta análise o diálogo com a literatura, o acesso a documentos educacionais governamentais e a informações disponíveis em sites institucionais das universidades. Os resultados apontam para relações incipientes e periféricas entre a cultura e a Educação Física na produção de conhecimento e no campo escolar dos países investigados, as quais tendem a ser potencializadas a partir de interesses emergentes de pesquisadores que têm intensificado o diálogo com as ciências humanas e sociais no intuito de contribuircom a área.