bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of the load graph for consumers of electric energy for the stabilizing work of electric energy system
Authors: Udintsev D N , Shvedov G V , Milovanov P К , Sergeeva M M 
Published: May 2020

Abstract
Design and operation of electric energy system is being carried out with taking into account probable projected accidents. Thus, there are many prerequisites of developing accidents in electric energy systems, caused by impact of outer factors, which have random nature and can negatively influence the stability of operation of electric energy system. Problematic questions of functioning of electric energy systems in accidents, caused by various factors, which have both predicted and random nature are being considered in this article. There are actual ways of preventing development of accidents provided. A method of flexible regulation of consumption of electric energy had been suggested as one of the possible ways to stabilize the operation of electric energy system.
Personality Traits, Coping, Health-related Behaviors, and Cumulative Physiological Health in a National Sample: 10 Year Prospective Effects of Conscientiousness via Perceptions of Activity on Allostatic Load
Authors: Milad Elizabeth , Bogg Tim 
Published: May 2020

AbstractBackgroundPersonality traits, coping styles, and health-related behaviors show associations with various aspects of health. However, integrative life-course investigations of pathways by which these factors might affect later cumulative physiological health risk remain sparse.PurposeTo investigate prospective associations of personality traits via coping styles and health-related behaviors on allostatic load in a national sample.MethodsUsing data from the Midlife in the United States study (MIDUS; N = 1,054), path analyses were used to test direct and indirect associations (via coping styles, smoking, frequency of alcohol consumption, leisure-time physical activity, and perceptions of activity) of personality traits on a latent measurement model of allostatic load informed by 10 biomarkers associated with cardiovascular, inflammation, glucose, and lipid subsystems.ResultsDirect 10 year associations of greater conscientiousness on healthier allostatic load and greater extraversion on less healthy allostatic load were observed. Consistent with hypothesized behavioral pathways, relationships between conscientiousness and extraversion on allostatic load were prospectively mediated by greater perceptions of activity. Physical activity and more frequent alcohol use were associated with healthier allostatic load but did not act as prospective mediators.ConclusionsThe results provide further evidence of conscientiousness’ standing as a marker of health via cumulative physiological health. Moreover, a greater perception of activity was identified as a pathway through which conscientious individuals experienced healthier physiological profiles over time. Examining a more detailed picture of the psychosocial mechanisms leading to development of health risk, as was found with perceptions of activity, remains an important area for future research.
Expanding Clinical Indications of Mechanically Isolated Stromal Vascular Fraction: A Systematic Review
Authors: Ghiasloo Mohammad , Lobato Rodolfo C , Díaz Juan M , Singh Kashika , Verpaele Alexis , Tonnard Patrick 
Published: May 2020

Abstract

Background
Mechanically isolated stromal vascular fraction (tSVF, tissue SVF) is a potent regenerative solution, increasingly used as a therapeutic modality for a variety of pathologies. With recent evidence conclusively favoring mechanical isolation over enzymatic alternatives, the therapeutic share and indications of tSVF are expected to grow even further.

Objectives
The aim of this study was to provide a systematic review of all studies reporting on the use of tSVF.

Methods
A systematic search was undertaken of the Embase, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials databases. Outcome measures included clinical indications, such as recipient area, adverse events, clinical results recipient area, method of application, follow-up duration and evaluation methods.

Results
Of the total of 4505 articles identified, 186 full-texts were screened. Thirty-four studies, reporting on 1443 patients were included. tSVF-based therapy was observed for 10 different pathologies, including aged skin (8 studies), scars (5), wounds (6), osteoarthritis (6), tendinopathy (2), temporomandibular joint disorders (1), androgenic alopecia (1), perianal fistula (3), migraine (1), and vocal fold scarring (1). Across all studies, tSVF-based therapy resulted in favorable clinical results. Overall, 50 (3.43%) minor and one (0.07%) major adverse events were observed, mainly related to the liposuction procedure.

Conclusions
tSVF offers a safe, easy and legal treatment modality for a range of indications. Future research is indicated to identify the optimal isolation protocol, dose and timing. In addition, basic research remains crucial to identify the mechanism of action of SVF within different pathologies.

Level of Evidence: 4
Cancer mutational signatures representation by large-scale context embedding
Authors: Zhang Yang , Xiao Yunxuan , Yang Muyu , Ma Jian 
Published: May 2020

Abstract

Motivation
The accumulation of somatic mutations plays critical roles in cancer development and progression. However, the global patterns of somatic mutations, especially non-coding mutations, and their roles in defining molecular subtypes of cancer have not been well characterized due to the computational challenges in analysing the complex mutational patterns.

Results
Here, we develop a new algorithm, called MutSpace, to effectively extract patient-specific mutational features using an embedding framework for larger sequence context. Our method is motivated by the observation that the mutation rate at megabase scale and the local mutational patterns jointly contribute to distinguishing cancer subtypes, both of which can be simultaneously captured by MutSpace. Simulation evaluations show that MutSpace can effectively characterize mutational features from known patient subgroups and achieve superior performance compared with previous methods. As a proof-of-principle, we apply MutSpace to 560 breast cancer patient samples and demonstrate that our method achieves high accuracy in subtype identification. In addition, the learned embeddings from MutSpace reflect intrinsic patterns of breast cancer subtypes and other features of genome structure and function. MutSpace is a promising new framework to better understand cancer heterogeneity based on somatic mutations.

Availability and implementation
Source code of MutSpace can be accessed at: https://github.com/ma-compbio/MutSpace.

Supplementary information
Supplementary data are available at Bioinformatics online.
Reusable Fuzzy Extractor Based on the LPN Assumption
Authors: Li Yiming , Liu Shengli , Gu Dawu , Chen Kefei 
Published: May 2020

Abstract
A fuzzy extractor derives uniformly random strings from noisy sources that are neither reliably reproducible nor uniformly random. The basic definition of fuzzy extractor was first formally introduced by Dodis et al. and has achieved various applications in cryptographic systems. However, it has been proved that a fuzzy extractor could become totally insecure when the same noisy random source is extracted multiple times. To solve this problem, the reusable fuzzy extractor is proposed. In this paper, we propose the first reusable fuzzy extractor based on the LPN assumption, which is efficient and resilient to linear fraction of errors. Furthermore, our construction serves as an alternative post-quantum reusable fuzzy extractor.
Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry
Authors: Wali Jibran A , Raubenheimer David , Senior Alistair M , Le Couteur David G , Simpson Stephen J 
Published: May 2020

AbstractCarbohydrates are the major source of dietary energy, but their role in health and disease remains controversial. Recent epidemiological evidence suggests that the increased consumption of carbohydrates is associated with obesity and increased risk of mortality and dietary trials show that carbohydrate restriction leads to weight loss and improved glycaemic status in obese and diabetic subjects. In contrast, the diets of populations with long and healthy lifespans (e.g. traditional Okinawans from Japan) are high in carbohydrate and low in protein, and several clinical and preclinical studies have linked low-carbohydrate–high-protein diets with increased mortality risk. In this paper we attempt to reconcile these contradictory findings by moving beyond traditional single-nutrient analyses to consider the interactions between nutrients on health outcomes. We do so using the Geometric Framework (GF), a nutritional modelling platform that explicitly considers the main and interactive effects of multiple nutrients on phenotypic characteristics. Analysis of human data by GF shows that weight loss and improved cardio-metabolic outcomes under carbohydrate restriction derive at least in part from reduced caloric intake due to the concomitantly increased proportion of protein in the diet. This is because, as in many animals, a specific appetite for protein is a major driver of food intake in humans. Conversely, dilution of protein in the diet leverages excess food intake through compensatory feeding for protein (‘protein leverage’). When protein is diluted in the diet by readily digestible carbohydrates and fats, as is the case in modern ultra-processed foods, protein leverage results in excess calorie intake, leading to rising levels of obesity and metabolic disease. However, when protein is diluted in the diet by increased quantities of less readily digestible forms of carbohydrate and fibre, energy balance is maintained and health benefits accrue, especially during middle age and early late-life. We argue that other controversies in carbohydrate research can be resolved using the GF methodology in dietary studies.
The First Draft Genome of the Plasterer Bee Colletes gigas (Hymenoptera: Colletidae: Colletes)
Authors: Zhou Qing-Song , Luo Arong , Zhang Feng , Niu Ze-Qing , Wu Qing-Tao , Xiong Mei , Orr Michael C , Zhu Chao-Dong 
Published: May 2020

AbstractDespite intense interest in bees, no genomes are available for the bee family Colletidae. Colletes gigas, one of the largest species of the genus Colletes in the world, is an ideal candidate to fill this gap. Endemic to China, C. gigas has been the focus of studies on its nesting biology and pollination of the economically important oil tree Camellia oleifera, which is chemically defended. To enable deeper study of its biology, we sequenced the whole genome of C. gigas using single-molecule real-time sequencing on the Pacific Bioscience Sequel platform. In total, 40.58 G (150×) of long reads were generated and the final assembly of 326 scaffolds was 273.06 Mb with a N50 length of 8.11 Mb, which captured 94.4% complete Benchmarking Universal Single-Copy Orthologs. We predicted 11,016 protein-coding genes, of which 98.50% and 84.75% were supported by protein- and transcriptome-based evidence, respectively. In addition, we identified 26.27% of repeats and 870 noncoding RNAs. The bee phylogeny with this newly sequenced colletid genome is consistent with available results, supporting Colletidae as sister to Halictidae when Stenotritidae is not included. Gene family evolution analyses identified 9,069 gene families, of which 70 experienced significant expansions (33 families) or contractions (37 families), and it appears that olfactory receptors and carboxylesterase may be involved in specializing on and detoxifying Ca. oleifera pollen. Our high-quality draft genome for C. gigas lays the foundation for insights on the biology and behavior of this species, including its evolutionary history, nesting biology, and interactions with the plant Ca. oleifera.
The Centrality of Ancestral Grandmothering in Human Evolution
Authors: Hawkes Kristen 
Published: May 2020

AbstractWhen Fisher, Williams, and Hamilton laid the foundations of evolutionary life history theory, they recognized elements of what became a grandmother hypothesis to explain the evolution of human postmenopausal longevity. Subsequent study of modern hunter-gatherers, great apes, and the wider mammalian radiation has revealed strong regularities in development and behavior that show additional unexpected consequences that ancestral grandmothering likely had on human evolution, challenging the hypothesis that ancestral males propelled the evolution of our radiation by hunting to provision mates and offspring. Ancestral grandmothering has become a serious contender to explain not only the large fraction of post-fertile years women live and children’s prolonged maturation yet early weaning; it also promises to help account for the pair bonding that distinguishes humans from our closest living evolutionary cousins, the great apes (and most other mammals), the evolution of our big human brains, and our distinctive preoccupation with reputations, shared intentionality and persistent cultural learning that begins in infancy.
Hitting The Right Spot: NMDA Receptors in the Auditory Thalamus May Hold the Key to Understanding Schizophrenia
Authors: Xiao Gang , Llano Daniel A 
Published: May 2020

Abstract
In this issue, Wang and colleagues solve an important puzzle in the understanding of schizophrenia. Previous work has linked N-methyl-D-aspartate (NMDA) receptor hypofunction to schizophrenia and shown that individuals with schizophrenia have a suppressed steady-state cortical response to 40-Hz repetitive auditory stimulation. However, systemic application of NMDA antagonists paradoxically increases this cortical response in rodents. Here, by specifically applying NMDA receptor blockade in the auditory thalamus while simultaneously measuring the acoustically driven response in 2 cortical regions, Wang and colleagues found the drop in the steady-state response that is seen in schizophrenia. These findings solve an important paradox in the field and suggest that specific thalamic neurochemical alterations may occur in the brain of individuals with schizophrenia. In addition, this work suggests that suppression of NMDA receptors in the thalamus may serve as a potential animal model for the disease.
Overview of Risk Factors and Strategies for Management of Insect-Derived Ear Injury and Aflatoxin Accumulation for Maize Grown in Subtropical Areas of North America
Authors: Pruter Luke S , Weaver Mark , Brewer Michael J 
Published: May 2020

Abstract
Pest and disease risk factors causing maize yield and kernel quality issues in subtropical areas of North America (between 35°N and 23.5°N latitude) are reviewed: preharvest Aspergillus flavus (Link) (Deuteromycetes: Moniliales) infection and propagation in maize ears and ear injury principally caused by Helicoverpa zea (Boddie) and Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae). Risk is affected by potentially interacting factors of maize genetics, ear feeding with insects, fungal inoculum and growth, and weather (rainfall, temperature, and humidity). This review gives special attention to integration of the most efficient pest and disease management strategy combinations and the potential interaction of insect ear feeding and A. flavus occurrence. Management strategies reviewed include maximizing partial genetic resistance to A. flavus and selection of appropriate hybrids for the area, biological control of A. flavus using non-aflatoxigenic strains, avoiding pests and diseases using cultural practices like early planting, and reducing H. zea and S. frugiperda ear injury using Bt transgenes. Understanding the combined influences and identifying combined management approaches may lead to reduced aflatoxin risk and maintaining yield. This review focuses on subtropical areas of North America because the amount of maize produced in warm environments within or similar to subtropical maize production areas is likely to increase due to projected increases in demand for maize and predicted increases in temperature may increase pest and disease risk.
The Authority of the Common Morality
Authors: Trotter Griffin 
Published: May 2020

AbstractIn the third and subsequent editions of Principles of Biomedical Ethics, Tom Beauchamp and James Childress articulate a series of ethical norms that they regard as “derived” from, and hence carrying, the “authority” of the common morality. Although Beauchamp and Childress do not claim that biomedical norms they derive from the common morality automatically become constituents of the common morality, or that every detail of their account carries the authority of the common morality, they regard these derived norms as provisionally binding in a way that does not apply to the norms of mere “particular” moralities. Whereas particular moralities “do not bind other persons or communities,” Beauchamp and Childress have designed the norms of Principles of Biomedical Ethics to be “extensions” of the common morality that universally binds other persons and communities. Beauchamp and Childress seem to hold that (1) the norms they articulate in Principles of Biomedical Ethics are derived in an objective way from the common morality, and also that by virtue of being so derived (2) they carry a moral authority that objectively exceeds the authority of norms constituting particular moralities. My thesis in this essay is that both of these claims are false.
Why ‘the uplift of the Tibetan Plateau’ is a myth
Authors: Spicer Robert A , Su Tao , Valdes Paul J , Farnsworth Alexander , Wu Fei-Xiang , Shi Gongle , Spicer Teresa E V , Zhou Zhekun 
Published: May 2020

AbstractThe often-used phrase ‘the uplift of the Tibetan Plateau’ implies a flat-surfaced Tibet rose as a coherent entity, and that uplift was driven entirely by the collision and northward movement of India. Here, we argue that these are misconceptions derived in large part from simplistic geodynamic and climate modeling, as well as proxy misinterpretation. The growth of Tibet was a complex process involving mostly Mesozoic collisions of several Gondwanan terranes with Asia, thickening the crust and generating complex relief before the arrival of India. In this review, Earth system modeling, paleoaltimetry proxies and fossil finds contribute to a new synthetic view of the topographic evolution of Tibet. A notable feature overlooked in previous models of plateau formation was the persistence through much of the Cenozoic of a wide east–west orientated deep central valley, and the formation of a plateau occurred only in the late Neogene through compression and internal sedimentation.
Model State Legislation and Intergovernmental Tensions over the Affordable Care Act, Common Core, and the Second Amendment
Authors: Callaghan Timothy , Karch Andrew , Kroeger Mary 
Published: May 2020

AbstractThe safeguards of federalism provide state officials with several tools as they try to influence national policy and protect their interests. State legislative challenges to the national government have been widespread recently, yet little is known about their origins. Are they derived from model legislation provided by interest groups, the result of state-to-state emulation, or developed independently by individual states? This article uses plagiarism detection software to offer a preliminary answer to this question. Our analysis suggests that state officials only occasionally rely on model legislation in drafting resistance measures. It also identifies variation across issues. External sources seem to have the greatest impact on legislation resisting gun control, a more modest influence on challenges to the Affordable Care Act, and a minimal effect on state-level responses to Common Core. The article further analyzes these dynamics by examining specific examples of textual overlap among resistance bills in each issue area.
The Deregulation of the Private Equity Markets and the Decline in IPOs
Authors: Ewens Michael , Farre-Mensa Joan 
Published: May 2020

AbstractThe deregulation of securities laws—in particular the National Securities Markets Improvement Act (NSMIA) of 1996—has increased the supply of private capital to late-stage private startups, which are now able to grow to a size that few private firms used to reach. NSMIA is one of a number of factors that have changed the going-public versus staying-private trade-off, helping bring about a new equilibrium where fewer startups go public, and those that do are older. This new equilibrium does not reflect an initial public offering (IPO) market failure. Rather, founders are using their increased bargaining power vis-à-vis investors to stay private longer.
The characterization of two novel neotropical primate papillomaviruses supports the ancient within-species diversity model
Authors: D’arc Mirela , Moreira Filipe R R , Dias Cecilia A , Souza Antonizete R , Seuánez Héctor N , Soares Marcelo A , Tavares Maria C H , Santos André F A 
Published: May 2020

Abstract
Papillomaviruses (PVs) are non-enveloped icosahedral viruses with a circular double-stranded DNA genome of ∼8,000 base pairs (bp). More than 200 different PV types have been identified to date in humans, which are distributed in five genera, with several strains associated with cancer development. Although widely distributed in vertebrates, Neotropical Primates (NP) PV infection was described for the first time only in 2016. Currently, four complete genomes of NP PVs have been characterized, three from Saimiri sciureus (SscPV1 to SscPV3) and one from Alouatta guariba (AgPV1). In this work, we describe two novel PV strains infecting Callithrix penicillata (provisionally named CpenPV1 and CpenPV2), using anal swab samples from animals residing at the Brasilia Primatology Center and next generation sequencing. The genomes of CpenPV1 (7,288 bp; 41.5% guanine-cytosine content - GC) and CpenPV2 (7,250 bp; 40.7% GC) contain the characteristic open reading frames (ORFs) for the early (E6, E7, E1, E2, and E4) and late (L2 and L1) PV genes. The L1 ORFs, commonly used for phylogenetic identification, share 76 per cent similarity with each other and differ 32 per cent from any other known PV, indicating that these new strains meet the criteria for defining novel species. PV genes phylogenetic variance was analyzed and different degrees of saturation revealed similar levels of topological heterogeneity, ruling out saturation as primary etiological factor for this phenomenon. Interestingly, the two CpenPV strains form a monophyletic clade within the Gammapapillomavirus genus (provisionally named gammapapillomavirus 32). Unlike for other NP PV strains, which grouped into a new sister genus of Alphapapillomavirus, this is the first report of NP PV strains grouping into a genus previously considered to exclusively comprise Old World Primates (OWP) PVs, including human PVs. These findings confirm the existence of a common ancestor for Gammapapillomavirus already infecting primates before the split of OWP and NP at ∼40 million years ago. Finally, our findings are consistent with an ancient within-species diversity model and emphasize the importance of increasing sampling to help understanding the PV-primate codivergence dynamics and pathogenic potential.