bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of superimposed nephrological care to guidelines-directed management by primary care physicians of patients with chronic kidney disease: a randomized controlled trial
Authors: Saudan Patrick , Ponte Belen , Marangon Nicola , Martinez Chantal , Berchtold Lena , Jaques David , Ernandez Thomas , De Seigneux Sophie , Carballo Sebqastian , Perneger Thomas , Martin Pierre-Yves 
Published: November 2019

Abstract
Background: Optimal clinical care of patients with chronic kidney disease (CKD) requires collaboration between primary care physicians (PCP) and nephrologists. We undertook a randomised trial to determine the impact of superimposed nephrologist care compared to guidelines-directed management by PCPs in CKD patients after hospital discharge. Methods: Stage 3b-4 CKD patients were enrolled during a hospitalization and randomised in two arms: Co-management by PCPs and nephrologists (interventional arm) versus management by PCPs with written instructions and consultations by nephrologists on demand (standard care). Our primary outcome was death or rehospitalisation within the 2 years post-randomisation. Secondary outcomes were: urgent renal replacement therapy (RRT), decline of renal function and decrease of quality of life at 2 years. Results: From November 2009 to the end of June 2013, we randomised 242 patients. Mean follow-up was 51 + 20 months. Survival without rehospitalisation, GFR decline and elective dialysis initiation did not differ between the two arms. Quality of life was also similar in both groups . Compared to randomised patients, those who either declined to participate in the study or were previously known by nephrologists had a worse survival. Conclusion: These results do not demonstrate a benefit of a regular renal care compared to guided PCPs care in terms of survival or dialysis initiation in CKD patients. Increased awareness of renal disease management among PCPs may be as effective as a co-management by PCPs and nephrologists in order to improve the prognosis of moderate-to-severe CKD.
Pain management with ultrasound-guided lidocaine-ropivacaine caudal block in hypospadias repair: A single-surgeon comparative study
Authors: Dai Shuangbo , Chen Min , HE Shaohua 
Published: November 2019

Abstract
Background: Postoperative pain management in hypospadias surgery can be challenging, especially with the occurrence of postoperative penile erection, which is usually accompanied with bleeding and often interferes with wound healing. Ultrasound-guided caudal epidural block is easy to administer and can attenuate postoperative physiological stress response. In this study, we compared the effect of pain control among patients receiving standard general anesthesia (Group G) and among those receiving caudal analgesics of lidocaine-ropivacaine (Group GC). Methods: A total of 100 patients needing hypospadias repair for the first time were consecutively enrolled; 50 patients received caudal analgesics depending on available anesthesiologists. All patients were operated on by the same experienced surgeon. Primary outcome included pain and sedation scores, and the incidence of painful erections within 24 hours following surgery. Heart rate (HR) and analgesic requirement were also compared. Results: Baseline characteristics and vital statistics did not differ between the two groups. Postoperative erections were significantly less frequent in the GC than in the G group (22% vs. 64%, P < 0.05). The HRs and pain scores of the GC group were lower than those of the G group (P < 0.05) in the first 12 hours. Postoperative sedative effect was better and analgesic requirement less for the GC than the G group (P < 0.05) in the first 24 hours. Conclusion : Caudal lidocaine + ropivacaine can provide effective pain management in the early postoperative period and reduce the occurrence of painful erections. Further volume dosing studies are needed to refine the strategy for optimal pain control.
Endoscopic intraventricular hematoma evacuation surgery versus external ventricular drainage for the treatment of patients with moderate to severe intraventricular hemorrhage: a multicenter, randomized, controlled trial
Authors: Zhu Junhao , Tang Chao , Cong Zixiang , Yang Jin , Cai Xiangming , Liu Yuxiu , Ma Chiyuan 
Published: November 2019

Abstract
Background The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are small and all of them are retrospective studies. The aim of this study is to explore the prognosis of patients with moderate to severe IVH who undergo endoscopic IVH evacuation surgery versus those who undergo EVD alone.Methods The trial is a prospective, randomized, controlled, multi-center clinical trial. Nine hundred and fifty-six subjects with moderate to severe IVH across four tertiary hospitals in China will be randomly assigned (1:1) to receive either endoscopic IVH evacuation surgery or EVD. The primary objective is to compare patients’ survival rate at 12 months postoperatively after the two approaches.Discussion The trial is designed to investigate the prognostic benefits of endoscopic IVH evacuation surgery for patients with moderate to severe IVH. Currently, it has never been investigated in a prospective randomized controlled clinical trial.
Target controlled infusion pump occlusion alarm response times and their clinical implications: A bench-top and simulation study
Authors: Doyle Alexander , Kooij Viola , Stennings-Smith Philippa , Qureshi Syed , Tilakaratna Prasanna , Hassani Aimen 
Published: November 2019

Abstract
The authors have withdrawn the journal submission associated with this preprint and requested that the preprint also be withdrawn
The combination of the economic forecasts using expert information
Authors: Surkov A. A. 
Published: November 2019

Purpose of the study.The aim of this work is to consider the possibility of using expert information when combining forecasts as an additional factor in improving the accuracy of economic forecasting. Using the methodology of combining forecasts is increasingly found in the domestic practice of economic forecasting. Most researchers agree that combining forecasts improves forecasting accuracy by using all available information about the process under study, which is included in individual forecasting methods. Today, there are many methods for constructing weighting factors when combining forecasts, but all of them are primarily based on the use of only statistical information about the process under study. But economic forecasting cannot be linear in its dynamics, many external factors constantly affect the forecasted process, and some internal ones may not be affected by the methods used. In this case, it is necessary to attract expert information or external information about the forecast obtained in order to increase its accuracy and adjust the further development of the economic process. This is especially true today, during the period of digitalization of the economy and the increasing influence of social and political factors on the dynamics of economic phenomena. Materials and methods.For this purpose, methods of constructing integral indicators based on expert information or directly using such information at the stage of constructing a joint forecast can be directly used to make adjustments to the resulting combined forecast. Some of these approaches are already used in foreign practice of economic forecasting, while in domestic practice they are still little known. One of such approaches may be the use of the pairwise preference method or the application of Fishburn formulas for ranking particular forecasting methods by accuracy. The approaches considered in this work can be used as tools for constructing weight coefficients or as a correction of the obtained forecasting results. Results.As a result of this article, attempts have been made to propose possible methods for combining forecasts using expert information, a summary table has been compiled with an assessment of one or another method of combining forecasts, and conclusions are drawn on the appropriateness of their application in practice. Such a table will make it possible to better understand the direction of attracting expert information to combine forecasts and choose the most suitable approach for further use in practice. Conclusion.Combining forecasts has long established itself as an effective method for increasing forecast accuracy. This technique cannot degrade the result, in most cases increasing accuracy. The use of expert information in combining forecasts is the next step in improving this technique and requires a separate further practical study of possible tools for attracting expert information to the pool.
Identification of trends in the decline in US income over the past five decades
Authors: Kapitanov V. A. , Ivanova A. A. , Maksimova A. Y. 
Published: November 2019

The aim of the work is to test the well-known prediction of Karl Marx about the tendency to reduce the income of the proletariat under capitalism. The United States has been selected as the object of study as an advanced capitalist country with a relatively weakly developed public sector of the economy compared to other advanced capitalist countries and relatively small social transfers. In this work, by income reduction, we mean a massive phenomenon, involving at least 10% of the population and lasting for at least 10 years. The cyclical nature of the capitalist economy leads to sharp fluctuations in the income of the population, because of which problems arise during data processing: the downward trends can only be detected at sufficiently large intervals of time. Considering this, as research methods were the study of the largest possible amount of heterogeneous data. Direct data on the income of various statistical units, adopted in American statistics families, households, individuals, persons, direct data on wages, as well as indirect data on quality of life – long-term changes in average people height, life expectancy, specific number of prisoners were reviewed in this paper. All studied sources confirm the assumption of a long-term (approximately since 1969) decrease in the income of the majority (> 50%) or at least a significant proportion of the US population. All data presented in the article are the estimates below. In fact, the share of the population subject to a decrease in income is higher, and the depth of the fall in income is greater. The consumer price indices, used in the processing of data do not take into account the greater susceptibility of income of the poor to the influence of inflation; the indices do not take into account the hidden increase in prices for the goods associated with the deterioration of their quality. Externalities, connected with the economic growth are not considered, the poor primarily affect the influence of which. It is shown that the decline in income is deep enough to have negative physiological consequences – the growth of at least 50% of the population is reduced, the life expectancy of at least 15 ... 30% (depending on the source) of the population falls. It is noted that the physiological consequences of a decrease in income have a gender asymmetry – reducing the average median body height and a decrease in life expectancy is more pronounced for women than for men, despite the trend of equalization of incomes/wages for men and women. The decline in income is deep enough to have negative social consequences: in 1969, it led to a transition from a stable number of prisoners for decades to exponential growth; peak values of the specific number of prisoners in the 2000s are seven times higher than the level of 1969. As a reason for the decline in income, the hypothesis about the impact of rising US immigration was presented and rejected.
REKONSTRUKSI PENGATURAN PEMBINAAN LEMBAGA KEOLAHRAGAAN PASCA PUTUSAN MAHKAMAH KONSTITUSI NOMOR 19/PUU-XII/2014
Authors: Putra Hermawan Dwi , Anshari Tunggul , Lutfi Muhammad 
Published: November 2019

The study, titled “Reconstruction Of The Sport Institute Coaching Arragements In Legislation” aims to analyze the No. 3 Year 2005 about the National Immune System in the second generation of adults, the political system in Indonesia and the form of breaking up in the Constitution. The method used in this study is normative legal research, the approach taken Law approach, historical approach and comparative approach, there are three sources of legal material, namely the source of primary, secondary and tertiary legal materials. The legal material collection technique analyzes the Minutes of the Indonesian National System, a study of students by collecting and analyzing the population, as well as researchers from the internet. The analysis of the law in the study with descriptive descriptive techniques of the. The results showed that the problem can be concluded as the cause of the obscurity of the norms of the National Sports Committee in 36 articles (1) and (3), based on the SKN Draft Bill, the KONI is written National Sports with the aim to protect the citizenship of KONI. KOI only has to go to the internet and it will take an internal competition. The overlapping of authority in the development of sports due to the absence of legal certainty. Giving the concept of setting up KONI and KOI after being in the mid-1980s, KONI and KOI will eventually be led by a third, Reconstruction in the SKN Law makes it appear that it has a disadvantage so it does not cause conflict.
Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering
Authors: Dariš Barbara , Knez Željko 
Published: November 2019

Abstract
Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.
Beneficial effects of baicalein on a model of allergic rhinitis
Authors: Liu Tao , Xu Jing , Wu Yungang , Li Xiaoxia , Ding Detao , Ma Dengdian , Yao Mengwei , Wei Wenzhong , Zhang Wei , Wang Shaohua , Yao Jing , Li Xiaoyu 
Published: November 2019

Abstract
Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.
Qualitative and quantitative HPLC-ELSD-ESI-MS analysis of steroidal saponins in fenugreek seed
Authors: Król-Kogus Barbara , Głód Daniel , Krauze-Baranowska Mirosława 
Published: November 2019

Abstract
Fenugreek seeds are known as a source of various compounds, the most common of which are steroidal saponins. However, despite the growing interest in this plant material as a healing agent, spice and dietary supplement ingredient, the composition of Polish fenugreek seeds remains unknown. Therefore, the steroidal saponin complex in the seeds of T. foenum-graecum cultivated in Poland was qualitatively and quantitatively analyzed by the HPLC-ELSDESI-MS method. Two C-18 columns connected in series were used for the first time in analysis of fenugreek saponins and ELS detector parameters were optimized. A total of 26 furostanol saponins were revealed, of which 24 were tentatively identified. The HPLC-ELSD method developed for quantitative analysis was preliminarily validated and the determined amount of steroidal saponins in Polish fenugreek seeds was 0.14 %.
Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats
Authors: Guzmán David Calderón , Brizuela Norma Osnaya , Herrera Maribel Ortíz , Peraza Armando Valenzuela , Mejía Gerardo Barragán , Olguín Hugo Juárez , Jiménez Francisca Trujillo 
Published: November 2019

Abstract
The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, insulin (10 U per rat or 50 U kg−1); group 3, insulin + single dose of sildenafil (50 U kg−1 + 50 mg kg–1); group 4, insulin + three doses of sildenafil every 24 hours (50 U kg−1 + 50 mg kg−1). In groups 2, 3 and 4, insulin was administered every 24 hours for 10 days. Blood glucose was measured after the last treatment. On the last day of the treatment, the animals´ brains were extracted to measure the levels of oxidative stress markers [H2O2, Ca2+,Mg2+-ATPase, glutathione and lipid peroxidation (TBARS)], dopamine and 5-HIAA in the cortex, striatum and cerebellum/medulla oblongata by validated methods. The results suggest that administration of insulin in combination with sildenafil induces hypoglycemia and hypotension, enhances oxidative damage and provokes changes in the brain metabolism of biogenic amines. Administration of insulin and sildenafil promotes biometabolic responses in glucose control, namely, it induces hypoglycemia and hypotension. It also enhances oxidative damage and provokes changes in the brain metabolism of biogenic amines.
Differences in Water Vapor Adsorption-Desorption of Non Aged and 3-Year Aged Biochar in Sandy Spodosols
Authors: Balashov Eugene , Mukhina Irina , Rizhiya Elena 
Published: November 2019

Abstract
Ageing of biochars in soil affects their surface properties and can cause changes in water vapor adsorption-desorption processes. Measurements of hygroscopic water contents and corresponding water potentials of non aged and 3-year aged biochars as well as of sandy soils with medium and high quality were carried out during 5 cycles of water vapor adsorption-desorption processes at a room temperature of 23.5 °C. The results showed a significantly lower content of maximum hygroscopic water in the aged biochars than that in the non aged biochar at the end of water vapor adsorption processes at high air humidity. A significantly higher affinity of the high quality soil to water vapor resulted in insignificant differences in the maximum hygroscopic water content and in significant changes in the corresponding water potentials as compared to the same properties of the soil with medium quality. Minimum content of hygroscopic water was significantly lower in the non aged biochar than in the aged biochars at the end of the water desorption processes at ambient laboratory atmosphere. There were insignificant differences in minimum contents of hygroscopic water and in the corresponding water potentials of the aged biochars from soils with medium and high quality.
Sensitivity Analysis of Input Data in Surface Water Quality Models
Authors: Manina Martin , Halaj Peter 
Published: November 2019

Abstract
The article is focused on analysis of input data impact on outputs of water quality models. The authors examined the impact of roughness coefficient, both boundary and initial conditions setup on changes of outputs generated by HEC-RAS model. Simulation results have shown a various response rate of input data on simulated results. The strong impact shows roughness coefficient setup that through the value of longitudinal dispersion coefficient affects pollution transport process. Changes in boundary conditions have had less influence on outputs. Relatively strong impact shows the setup of initial state of pollution concentration along the reach mainly for the case of low gradient rivers.
The Results of Thrombolytic Treatment in Patients With High-risk Pulmonary Embolism
Authors: Atas Ali Ekber , Sarac Atilla , Dirican Adem , Topbası Nazlı , Uzar Tugce , Rastgar Ladan , Ekaterina Pankina , Ozkaya Sevket 
Published: November 2019

Abstract

Background: Mortality rates due to massive pulmonary embolism (PE) are much higher than estimated. Although thrombolytic therapy is controversial, it can be a life-saving procedure and can be safely used in patients with massive PE.

Study aim: We aimed to share the results of thrombolytic treatment in patients with massive PE.

Material and methods: We retrospectively evaluated 72 patients with PE admitted between January 2010 and April 2018 to the Department of Pulmonary Medicine, VM Medicalpark Samsun Hospital, Samsun, Turkey. The data of patients who received thrombolytic treatment were retrospectively analyzed.

Results: The female to male ratio was 24/48, with a mean age of 62.7 ± 12.6 (minimum 27, maximum 88) years. The diagnosis of massive PE was established with echocardiography in all patients and was confirmed via pulmonary CT angiography in 45 patients (62.5%) who presented an appropriate clinical status for this imaging technique. The most common symptoms were dyspnea (90.3%), chest pain (83.3%), and syncope (40.2%). The S1Q3T3 electrocardiography pattern was noted in 82% of patients, who rapidly recovered after thrombolytic therapy. Cardiopulmonary arrest was seen in 25 patients (37.2%), and thrombolytic treatment was administered during cardiopulmonary resuscitation in 18% (n = 13) of patients. The survival rate was 30.7% (n = 4) in patients with cardiopulmonary arrest who received thrombolytic treatment in the emergency room. The complications of rt-PA treatment included minor hemorrhages in 6.4% (n = 5), major hemorrhages in 2.7% (n = 2), and allergic reactions in 1.3% (n = 1) of patients. None of the patients had deceased as a complication of thrombolytic treatment. The overall mortality rate was 26.2% (n = 19), and 12.5% (n = 9) of the patients have died in first 24 hours after thrombolysis.

Conclusions: We concluded that the risk factors, ECG, and echocardiography are key indicators for the suspicion of massive PE in patients with hemodynamic shock. Based on our experience, early thrombolytic therapy is a life-saving intervention in patients with diagnosed and/or suspected massive PE.