bluuebunny/crossref_metadata_2025_split huggingface dataset:
РОЛЬ ТЕПЛОВИХ ЕФЕКТІВ У СТРУКТУРОУТВОРЕННІ ПРИ КРИСТАЛІЗАЦІЇ ВИСОКОМІЦНИХ ЧАВУНІВ
Authors: Кропівний В. М. , Кропівна А. В. , Босий М. В. , Кузик О. В. 
Published: December 2019

В статті обґрунтовано роль теплофізичних процесів у формуванні включень вермикулярного та кулястого графіту, із забезпеченням їх росту за рахунок дифузії вуглецю з розплаву через аустенітну оболонку. Наведено розрахунок теплових ефектів за теплотою утворення реагентів в чавуні та встановлено їх залежність від температурного фактору.
MODELAGEM DO FENÔMENO DE TRANSFERÊNCIA DE MASSA NA HIDRATAÇÃO DO CEREAL MATINAL
Authors: Ibiapina Andreia , Silva de Oliveira Eduardo Henrique , De Souza Martins Glêndara Aparecida , Gramacho da Silva Warley 
Published: December 2019

A crocância do cereal matinal está associada a qualidade do produto e é de suma importância dentre suas características sensoriais. O processo de hidratação o qual ele geralmente sofre antes de ser ingerido, pode ocasionar alterações nesta característica e alguns fatores como, quantidade de fluido disponível, temperatura e tempo de hidratação afetam diretamente esse processo. O objetivo do trabalho foi utilizar modelos empíricos (Cinético de 1ª Ordem e Exponencial) afim de avaliar os parâmetros de hidratação de um cereal matinal hidratado com leite. A hidratação ocorreu em 3 proporções, 3 temperaturas e durante 2 horas, sendo analisadas amostras desse cereal e do leite a cada 15 minutos de hidratação. Dos modelos empíricos, o modelo exponencial foi o que melhor descreveu a cinética de hidratação, porém, nenhum dos dois modelos utilizados mostraram parâmetros de ajustes tão satisfatórios, fazendo necessário o uso de outro modelo que melhor se ajuste aos dados experimentais.
PENENTUAN KOMODITAS UNGGULAN PERIKANAN LAUT KABUPATEN POLEWALI MANDAR BERDASARKAN DATA STATISTIK TAHUN 2016
Authors: Ridwan Muhammad , Kasmi Mauli , Putri Andi Rani Sahni 
Published: December 2019

Komoditas unggulan sektor perikanan laut merupakan salah satu komoditas strategis untuk meningkatkan pendapatan asli daerah. Penelitian ini bertujuan untuk menentukan komoditas perikanan tangkap yang menjadi unggulan di Kabupaten Polman, Sulawesi Barat. Penelitian ini menggunakan metode deskriptif dan metode pengambilan sampel adalah purposive sampling berbasis data statistik tahun 2016. Analisis yang digunakan dalam peneltian adalah Location Quotient (LQ), dan analisis Specialization Index (SI). Penentuan komoditas unggulan apabila baik nilai LQ maupun SI >1. Perangkingan komoditas menggunakan indeks komoditi. Hasil penelitian menunjukkan bahwa komoditas perikanan tangkap Kabupaten Polman di Sulawesi Barat yang menjadi unggulan utama adalah ikan teri (Stolephorus Sp), ikan madidihang (Thunnus albacores), ikan cakalang (Katsuwonus pelamis) dan ikan biji nangka (Upeneus moluccensis). Diantara keempat komoditas unggulan tersebut, ikan madidihang memiliki nilai LQ dan SI yang paling tinggi yaitu 1.87 dan 10.19. Hasil ini berimplikasi pada pentingnya strategi penangkapan dan pengelolaan ikan tuna madidihang di Kabupaten Polman untuk meningkatkan pendapatan daerah. Kata kunci: Komoditas Unggulan, perikanan laut, LQ, SI dan Kabupaten Polewali Mandar
BEBERAPA FAKTOR YANG MENYEBABKAN KEMISKINAN NELAYAN DI GUGUS KEPULAUAN SALABANGKA KECAMATAN BUNGKU SELATAN KABUPATEN MOROWALI PROVINSI SULAWESI TENGAH
Authors: Lanuhu Nurdin 
Published: December 2019

Penelitian ini dilaksanakan di Gugus Kepulauan Salabangka Kecamatan Bungku Selatan Kabupaten Morowali Propinsi Sulawesi Tengah, pada bulan Juli 2016 sampai dengan Agustus 2016. Lokasi penelitian dipilih secara purposif dengan pertimbangan bahwa Gugus Kepulauan Salabangka Kecamatan Bungku Selatan Kabupaten Morowali penduduknya umumnya bermata pencaharian sebagai nelayan dan memiliki jumlah penduduk miskin yang terbanyak di Kabupaten Morowali. Penelitian ini bertujuan melakukan kajian terhadap faktor-faktor penyebab kemiskinan di Gugus Kepulauan Salabangka Kecamatan Bungku Selatan Kabupaten Morowali Provinsi Sulawesi Tengah. Sementara kegunaan yang diharapkan alam penelitian adalah tersedianya data dan informasi factor- factor penyebab kemiskinan yang dapat digunakan oleh berbagai pihak dalam menyusun model pemberdayaan masyarakat nelayan dalam penenggulangan kemiskinan di Kabupaten Morowali. Penelitian ini didesain dengan menggunakan mixed method approach, dengan menggabungkan Quantitative and Qualitative Research Designs secara simultan. Sedangkan Qualitative Research Design menggunakan metode Focus Group Discussion (FGD). Pendekatan ini dilakukan untuk memperoleh data dan informasi yang komprehensif dan saling melengkapi, sehingga situasi riel di lapangan dapat dideskripsikan dengan baik. Adapun proses tahapan penelitian ini adalah Review literature, Kunjungan Lapangan, Uji kuisioner dan FGD, pengumpulan data primer dan sekunder. Hasil Penelitian menunjukkan bahwa beberapa faktor yang mennyebabkan kemiskinan di Gugus Kepulauan Salabangka Kecamatan Bungku Selatan Kabupaten Morowali Provinsi Sulawesi Tengah adalah Keadaan Musim, Struktur Sosial, Pengelolaan Pendapatan, Pencemaran Lingkungan dan Pelayanan Pemerintah dibidang pemerintahan, pendidikan, kesehatan dan sarana prasarana tranportasi.Guna mengentaskan kemiskinan maka direkomendasikan 1) Pengembangan ekonomi kerakyatan berbasis potensi lokal, 2) Perbaikan pelayanan pemerintah dalam bidang pemerintahan, pendidikan, kesehatan dan penyediaan sarana transportasi laut. Kata Kunci : Nelayan, Kemiskinan, Pulau
School-based nutrition interventions for Indigenous children in Canada: A scoping review
Authors: Gillies Christina , Blanchet Rosanne , Gokiert Rebecca , Farmer Anna , Thorlakson Jessica , Hamonic Laura , Willows Noreen D. 
Published: December 2019

Abstract
Background Indigenous children in Canada (First Nations, Inuit, and Métis) are disproportionately affected by nutrition-related chronic diseases such as obesity and diabetes. Comprehensive school-based nutrition interventions offer a promising strategy for improving children’s access to healthy foods and sustaining positive eating behaviors. However, little is known about school-based nutrition interventions for Indigenous children. The objectives of this scoping review were to identify school-based nutrition interventions for Indigenous children in Canada and describe their components. Methods The scoping review consisted of searches in seven peer-reviewed databases and a general web search for grey literature. Eligibility criteria were applied by two reviewers, and data were extracted and charted by one reviewer using components of the comprehensive school health approach (social and physical environment, teaching and learning, policy, partnerships and services) and additional components with relevance to Indigenous interventions (cultural content, Indigenous control and ownership, funding source, evaluation). Numerical and descriptive summaries were used to present findings. Results Thirty-four unique interventions met the inclusion criteria. The majority (97%) of interventions targeted the social and physical environment, most often by offering food programs. Over half of interventions also incorporated teaching and learning (56%) and partnerships and services (59%), but fewer included a policy component (38%). Many interventions included a cultural component (56%) and most (62%) were owned and controlled by Indigenous communities (62%). Finally, over half of interventions disclosed their source(s) of funding (59%), but less than half (41%) included an evaluation component. Conclusions The review suggests that school-based interventions for Indigenous children can be more comprehensive by incorporating culturally relevant nutrition education and professional development opportunities for teachers, written school nutrition policies, and activities that actively engage families and community members. The continued focus on Indigenous control and ownership and incorporation of content specific to individual communities may enhance cultural relevancy and sustainability of interventions. Furthermore, there is a need to increase intervention evaluation and the sharing of resources related to funding. These recommendations may be used by communities, as well as by researchers and professionals working with communities, in developing comprehensive school-based nutrition interventions to improve the eating behaviors of Indigenous children.
Impact of weight trajectory after bariatric surgery on co-morbidity evolution and burden
Authors: Davis Jason , Saunders Rhodri 
Published: December 2019

Abstract
Background Bariatric surgery, such as Roux-en-Y gastric bypass [RYGB] has been shown to be an effective intervention for weight management in select patients. After surgery, different patients respond differently even to the same surgery and have differing weight-change trajectories . The present analysis explores how improving a patient’s post-surgical weight change could impact co‑morbidity prevalence, treatment and associated costs in the Canadian setting. Methods Published data were used to derive statistical models to predict weight loss and co‑morbidity evolution after RYGB. Burden in the form of patient-years of co-morbidity treatment and associated costs was estimated for a 100-patient cohort on one of 6 weight trajectories, and for real-world simulations of mixed patient cohorts where patients experience multiple weight loss outcomes over a 10-year time horizon after RYGB surgery. Costs (2018 Canadian dollars) were considered from the Canadian public payer perspective for diabetes, hypertension and dyslipidaemia. Robustness of results was assessed using probabilistic sensitivity analyses using the R language. Results Models fitted to patient data for total weight loss and co-morbidity evolution (resolution and new onset) demonstrated good fitting. Improvement of 100 patients from the worst to the best weight loss trajectory was associated with a 50% reduction in 10-year co-morbidity treatment costs, decreasing to a 27% reduction for an intermediate improvement. Results applied to mixed trajectory cohorts revealed that broad improvements by one trajectory group for all patients were associated with 602, 1,710 and 966 patient-years of treatment of type 2 diabetes, hypertension and dyslipidaemia respectively in Ontario, the province of highest RYGB volume, corresponding to a cost difference of $3.9 million. Conclusions Post-surgical weight trajectory, even for patients receiving the same surgery, can have a considerable impact on subsequent co-morbidity burden. Given the potential for alleviated burden associated with improving patient trajectory after RYGB, health care systems may wish to consider investments based on local needs and available resources to ensure that more patients achieve a good long-term weight trajectory.
Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis
Authors: LIU Deyu , jian xinchun , XU PU , ZHU Rong , WANG Yuan 
Published: December 2019

Abstract
Background: Mounting studies demonstrate long non-coding RNA s ( lncRNAs ) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma ( OSCC ) still remain unclear.
Methods: We evaluated the expression profile and prognostic values of Linc01234 in OSCC tissues via RT-qPCR. Then, functional experiments in vitro were performed to investigate the effects of Linc01234 on tumor growth, migration and invasion in OSCC. Mechanistically, RT-qPCR, bioinformatic analysis and dual luciferase reporter assays were performed to identify a competitive endogenous RNA s ( ceRNA s) among Linc01234, miR-433-3p and PAK4.
Results: We found that Linc01234 was evidently upregulated in OSCC tissues and cell lines, and its level was positively associated with T stage, lymphnode metastasis, differentiation and poor prognosis of patients with OSCC. Our results found that Linc01234 inhibited cell proliferation and metastasis abilities in CAL27 and SCC25 cells following its deletion. Mechanistic analysis indicated that Linc01234 may act as a ceRNA (competing endogenous RNA) of miR-433-3p to relieve the repressive effect of miR-433-3p on its target PAK4.
Conclusions: Our results indicated that Linc01234 promotes OSCC progression through Linc01234/miR-433/PAK4 axis and might be a potential therapeutic target for OSCC.
Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease
Authors: Yu Xindi , Chen Maolin , Liu Xu , Chen Yiwei , Hao Zedong , Zhang Haibo , Wang Wei 
Published: December 2019

Abstract
Background: The aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD). Methods: We performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children’s Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0-1 months old), infants (1-12 months old) and children (1-10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed. Results: A total of 11651 subjects were included in the study. The overall nosocomial infection rate was 10.8%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 32.9%, 15.4%, and 5.2%, respectively. Multivariate logistic regression analysis found age (OR 0798, 95%CI: 0.769-0.829; P<0.001), STS risk grade (OR 1.267, 95%CI: 1.159-1.385; P<0.001), body mass index (BMI) <5th percentile (OR 1.295, 95%CI: 1.023-1.639; P=0.032), BMI ＞95th percentile (OR 0.792, 95%CI: 0.647-0.969; P=0.023), cardiopulmonary bypass (CPB) time (OR 1.008, 95%CI: 1.003-1.012; P<0.001) and aortic clamping time （OR 1.009, 1.002-1.015; P = 0.008）were significantly associated with nosocomial infection in CHD infants. After adjusted for confounding factors, we found STS risk grade (OR 1.38, 95%CI: 1.167-1.633; P<0.001), BMI<5th percentile (OR 1.934, 95%CI: 1.377-2.715; P<0.001), CPB time (OR 1.018, 95%CI: 1.015-1.022; P<0.001), lymphocyte/WBC ratio﹤cut off value (OR 3.818, 95%CI: 1.529-9.533; P=0.004) and AST＞cut off value (OR 1.546, 95%CI: 1.119-2.136; P=0.008) were significantly associated with nosocomial infection in CHD children. Conclusion: Our study suggested STS risk grade, BMI, CPB duration, low lymphocyte/WBC or high neutrophil/WBC ratio were independently associated with nosocomial infection in CHD infant and children after cardiac surgery.
Integrated transcriptome, small RNA and degradome sequencing approaches proffer insights into chlorogenic acid (CGA) biosynthesis in leafy sweet potato
Authors: Liu Yi , Su Wenjin , Wang Lianjun , Lei Jian , Chai Shasha , Jiao Chunhai , Zhang Wenying , Yang Xinsun 
Published: December 2019

Abstract
Background: Phenolic compounds play key roles in health protection and leafy sweet potato is an excellent source of total phenolics (TP). The chlorogenic acid (CGA) family, which includes caffeoylquinic acid (CQA), 3,4-O-dicaffeoylquinic acid (3,4-diCQA), 3,5-O-dicaffeoylquinic acid (3,5-diCQA) and 4,5-O-dicaffeoylquinic acid (4,5-diCQA) , constitutes the major components of phenolic compounds in leafy sweet potato. However, the mechanism of CGA biosynthesis in leafy sweet potato is unclear. The objective of present study is to dissect the mechanisms of CGA biosynthesis by using transcriptome, small RNA (sRNA) and degradome sequencing. Results: Transcriptome sequencing of twelve samples (triple replicates) from one low-CGA content genotype and one high-CGA content genotype at two stages (65 and 85 days after planting) identified a total of 2333 common differentially expressed genes (DEGs). The enriched DEGs were related to photosynthesis, starch and sucrose metabolism and phenylpropanoid biosynthesis. In this study, functional genes CCR , CCoAOMT and HCT in the CGA biosynthetic pathway were uniformly downregulated, indicating the way to lignin was altered, and two possible CGA biosynthetic routes were hypothesized. The sRNA sequencing identified a total of 38 DE miRNAs. Using in silico approaches, 1799 targets were predicated for 38 DE miRNAs. The target genes were enriched in lignin and phenylpropanoid catabolic processes. Transcription factors (TFs) such as apetala2 /ethylene response factor ( AP2/ERF ) and Squamosa promoter binding protein-like ( SPL ) predicated in silico were validated by degradome sequencing. Association analysis of the DE miRNAs and transcriptome datasets identified that miR156 family targeted DHQ / SDH (3-dehydroquinate dehydratase/shikimate dehydrogenase), the key gene in the phenylpropanoid pathway. Conclusions: This study established comprehensive functional genomic resources for the CGA biosynthesis and provided insights into the molecular mechanisms involving in this process. The results also enabled the first perceptions of the regulatory roles of mRNAs and miRNAs and offered candidate genes for leafy sweet potato improvement s.
Effect of inspiratory muscle loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia
Authors: Ogawa Takeshi , Nagao Maiko , Fujii Naoto , NIshiyasu Takeshi 
Published: December 2019

Abstract
Background: Although numerous studies have reported the effect of inspiratory muscle training for improving exercise performance, the outcome of whether exercise performance is improved by inspiratory muscle training is controversial. Therefore, this study investigated the influence of inspiratory muscle-loaded exercise training (IMLET) on peak oxygen uptake (VO2peak), respiratory responses, and exercise performance under normoxic (N) and hypoxic (H) exercise conditions. We hypothesised that IMLET enhances respiratory muscle strength and improves respiratory response, thereby improving VO2peak and work capacity under H condition.
Methods: Sixteen university track runners (13 men and 3 women) were randomly assigned to the IMLET (n=8) or exercise training (ET) group (n=8). All subjects underwent 4 weeks of 20-min 60% VO2peak cycling exercise training, thrice per week. IMLET loaded 50% of maximal inspiratory pressure during exercise. At pre- and post-training periods, subjects performed exhaustive incremental cycling under normoxic (N; 20.9 ± 0%) and hypoxic (H; 15.0 ± 0.1%) conditions.
Results: Although maximal inspiratory pressure (PImax) significantly increased after training in both groups, the extent of PImax increase was significantly higher in the IMLET group (from 102 ± 20 to 145 ± 26 cmH2O in IMLET; from 111± 23 to 127 ± 23 cmH2O in ET; P < 0.05). In both groups, VO2peak and maximal work load (Wmax) similarly increased both under N and H conditions after training (P < 0.05). Further, the extent of Wmax decrease under H condition was lower in the IMLET group at post-training test than at pre-training (from -14.7 ± 2.2% to -12.5 ± 1.7%; P < 0.05). Maximal minute ventilation in both N and H conditions increased after training than in the pre-training period.
Conclusions: Our IMLET enhanced the respiratory muscle strength, and the decrease in work capacity under hypoxia was reduced regardless of the increase VO2peak.
Sex differences in the association between self-reported sleep duration, insomnia symptoms and cardiometabolic risk factors: cross-sectional findings from ELSA-Brasil
Authors: Silva-Costa Aline , Rotenberg Lucia , Nobre Aline Araujo , Chor Dora , Aquino Estela , Melo Enirtes Caetano , Barreto Sandhi , Schmidt Maria Inês , Griep Rosane Härter 
Published: December 2019

Abstract
Background: The U-shaped associations between sleep durations and cardiometabolic risk factors (glycated hemoglobin levels, obesity, hypertriglyceridemia, hypertension and HDL-Cholesterol levels) are still inconclusive. Moreover, as sleep is comprised of quantitative and qualitative aspects, exploring both insomnia symptoms and sleep duration are relevant when evaluating the potential effects of sleep problems on health. The aim was to evaluate sex-specific associations between sleep problems and cardiometabolic risk factors. Methods: This cross-sectional study used data from wave two of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), including 7,491 women and 6,232 men. Questionnaires were administered to provide information about socioeconomic conditions, lifestyle, and sleep characteristics. A 12-hour fasting blood sample was drawn to measure serum cholesterol, triglycerides, and glycated hemoglobin. Blood pressure, weight and height were also measured using standard equipment. Generalized additive models were used to evaluate the curve shape of the relationship between self-reported sleep duration and the outcomes. Logistic regression was performed to investigate the magnitude of the associations of self-reported sleep duration, insomnia symptoms, and short sleep plus insomnia symptoms with cardiometabolic risk factors. Results: For women, self-reported sleep duration and insomnia symptoms (either separately or linked to short sleep duration) were associated with obesity, hypertension and glycated hemoglobin after adjusting for the confounders. The magnitudes of the associations between self-reported short sleep duration plus insomnia symptoms and the outcomes were slightly increased, considering sleep duration or insomnia symptoms separately. For men, both long sleep duration and insomnia symptoms were associated with hypertriglyceridemia after adjusted for the confounders. Conclusion: These findings suggest possible sex-specific patterns, since obesity, hypertension and high glycated hemoglobin were associated with self-reported sleep duration and insomnia symptoms in women, but not in men, and reinforce the importance of considering quantitative and qualitative aspects of sleep for the prevention and management of the outcomes.
Risk of late cervical cancer screening according to prosperity and medical density in daily frequented neighborhoods in Greater Paris.
Authors: TRAORE Médicoulé , Vallée Julie , CHAUVIN Pierre 
Published: December 2019

Abstract
Background: The consideration of multiple spaces frequented daily by individuals is attracting interest for the analysis of socioterritorial health and healthcare inequalities in light of the high daily mobility in urban settings and the increasing availability of mobility data. Our objective was to estimate the associations between attributes of daily frequented neighborhoods and delayed cervical smear tests in the Greater Paris area. Methods: Data were extracted from the 2010 SIRS cohort survey. Participants could report three neighborhoods (residence, work, and the next most regularly frequented). All multivariate analyses were conducted: simple multilevel logistic regression models, cross-classified multilevel logistic regression models were used to simultaneously consider the three types of neighborhoods studied (residential, work or study, visit) with active and mobile women. Finally, associations with socioeconomic and medical diversity scores (adjusted for the five individual characteristics) were estimated by logistic regression models that took sampling design into consideration. Results: One-quarter of the women reported that they had not had a smear test in the previous three years. After adjusting for individual characteristics, there was a significant association between the socioeconomic and medical diversity scores for the multiple neighborhoods frequented and the risk of a delayed smear test. Women who reside and work in poor neighborhoods and whose next most regularly frequented neighborhood was also poor had a significantly higher risk of late cervical cancer screening. Conclusions: In the characterization of social and territorial inequalities in healthcare, social epidemiology and health geography show a growing interest in considering multiple spaces frequented daily by individuals. A cumulative exposure score, such as the one presented here, may be a relevant approach for analyzing their effects. Keywords: Multilevel analysis, neighborhood, daily mobility, cancer prevention, cervical cancer, social inequalities, Paris area