bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review on the driving forces of water decline and its impacts on the environment in Poyang Lake, China
Authors: Li Qiyue , Lai Geying , Devlin Adam Thomas 
Published: November 2020

Abstract
The recession of water levels of natural lakes and their associated impacts on wetland ecosystems is a serious issue worldwide. Poyang Lake (the largest freshwater lake in China) has experienced a heightened and prolonged water decline since the year 2000, which causes concern for associated ecological impacts. In particular, climate change, operation of the Three Gorges Dam (TGD), and high magnitude sand mining appear to be well-correlated with the occurrence of water decline in Poyang Lake. Though the above factors have been analyzed in previous studies, a comprehensive summary has never been compiled. This paper provides a detailed literary review highlighting the driving forces and possible impacts of the consistent water decline in Poyang Lake. We conclude here that the operation of TGD is a fundamental cause for the lake water decline, aggravated by climate change and sand mining. The water decline has caused a deterioration of water quality, as well as having given rise to a potential threat to the habitat of migratory birds and Yangtze finless porpoises. The paper intends to offer constructive references that can be used in decision-making for effective protection of water resources and lake ecosystems.
Experimental Approaches to Identify Selective Picomolar Inhibitors for Carbonic Anhydrase IX
Authors: Kazokaitė-Adomaitienė Justina , Becker Holger M. , Smirnovienė Joana , Dubois Ludwig J. , Matulis Daumantas 
Published: November 2020

Background:Carbonic anhydrases (CAs) regulate pH homeostasis via the reversible hydration of CO2, thereby emerging as essential enzymes for many vital functions. Among 12 catalytically active CA isoforms in humans, CA IX has become a relevant therapeutic target because of its role in cancer progression. Only two CA IX inhibitors have entered clinical trials, mostly due to low affinity and selectivity properties.Objective:The current review presents the design, development, and identification of the selective nano- to picomolar CA IX inhibitors VD11-4-2, VR16-09, and VD12-09.Methods and Results:Compounds were selected from our database, composed of over 400 benzensulfonamides, synthesized at our laboratory, and tested for their binding to 12 human CAs. Here we discuss the CA CO2hydratase activity/inhibition assay and several biophysical techniques, such as fluorescent thermal shift assay and isothermal titration calorimetry, highlighting their contribution to the analysis of compound affinity and structure- activity relationships. To obtain sufficient amounts of recombinant CAs for inhibitor screening, several gene cloning and protein purification strategies are presented, including site-directed CA mutants, heterologous CAs from Xenopus oocytes, and native endogenous CAs. The cancer cell-based methods, such as clonogenicity, extracellular acidification, and mass spectrometric gas-analysis are reviewed, confirming nanomolar activities of lead inhibitors in intact cancer cells.Conclusions:Novel CA IX inhibitors are promising derivatives for in vivo explorations. Furthermore, the simultaneous targeting of several proteins involved in proton flux upon tumor acidosis and the disruption of transport metabolons might improve cancer management.
4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study
Authors: Venugopala Katharigatta N. , Deb Pran Kishore , Pillay Melendhran , Chopra Deepak , Chandrashekharappa Sandeep , Morsy Mohamed A. , Aldhubiab Bandar E. , Attimarad Mahesh , Nair Anroop B. , Sreeharsha Nagaraja , Kandeel Mahmoud , Venugopala Rashmi , Mohanlall Viresh 
Published: November 2020

Background:
Tuberculosis remains one of the most deadly infectious diseases worldwide
due to the emergence of multi-drug resistance (MDR) and extensively drug resistance (XDR) strains of
Mycobacterium tuberculosis (MTB).

Aims:
Currently, available drugs are getting resistant and toxic. Hence, there is an urgent need for the
development of potent molecules to treat tuberculosis.

Materials and Methods:
Herein, the screening of a total of eight symmetrical 1,4-dihydropyridine (1,4-
DHP) derivatives (4a-4h) was carried out for whole-cell anti-TB activity against the susceptible H37Rv
and MDR strains of MTB.

Results and Discussion:
Most of the compounds exhibited moderate to excellent activity against the
susceptible H37Rv. Moreover, the most promising compound 4f (against H37Rv) having paratrifluoromethyl
phenyl group at 4-position and bis para-methoxy benzyl ester group at 3- and 5-
positions of 1,4-dihydropyridine pharmacophore, exhibited no toxicity, but demonstrated weak activity
against MTB strains resistant to isoniazid and rifampicin. In light of the inhibitory profile of the title
compounds, enoyl-acyl carrier protein reductase (InhA) appeared to be the appropriate molecular target.
A docking study of these derivatives against InhA receptor revealed favorable binding interactions. Further,
in silico predicted ADME properties of these compounds 4a-4h were found to be in the acceptable
ranges, including satisfactory Lipinski’s rule of five, thereby indicating their potential as drug-like molecules.

Conclusion:
In particular, the 1,4-DHP derivative 4f can be considered an attractive lead molecule for
further exploration and development of more potent anti-TB agents as InhA inhibitors.
Diverse Pharmacological Potential of Various Furanone Derivatives: A Mini-Review
Authors: Husain Asif , Hussain Afzal , Mahdi Wael A. , Asif Mohammad 
Published: November 2020

Abstract::
Furanone is present in many natural compounds. Furanone derivatives are playing important roles in pharmaceutical
medicinal and organic chemistry. Various furanone derivatives were exhibited their different pharmacological activities
such as antimicrobial, anti-inflammatory, anticancer, antiviral, antioxidant, and other anticipated activities. Furanone derivatives
were also used as intermediate for synthesis of other organic compounds. In this review, we studied different types of
pharmacological activities of several furanone derivatives.
Clarithromycin Loaded Chitosan Nanoparticles: Development and Characterization
Authors: Herimatha Ashvini , Mutta Shivanand K , Bose Anirbandeep , Balla Anudeep 
Published: November 2020

Background::
Chitosan nanoparticles have been extensively studied and used due to
their well-recognized applicability in various fields. Chitosan, a natural polysaccharide polymer, is
extensively used in pharmaceuticals to deliver a wide variety of therapeutic agents. Chitosan is a
biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation
of multi particles, particularly nano- and microparticles.

Objective::
The main aim of the present study was to optimize the conditions for the preparation of
chitosan nanoparticles to get optimal particle size, with optimal zeta potential and narrow polydispersity
index and anti-bacterial activity.

Methods::
Include the ionic gelation technique for chitosan nanoparticle preparation. The influence
of formulation parameters and process parameters on the chitosan nanoparticles were investigated.
Besides, the suspension stability of the prepared nanoparticles was also assessed on storage at 4°C.

Results:
The formulation and process parameters showed a significant effect on the physicochemical
and morphological characteristics of the chitosan nanoparticles. The chitosan nanoparticles prepared
under optimum conditions (chitosan concentration of 0.5% w/v, CS: TPP mass ratio of 1:3,
initial pH of chitosan solution of 4.5, stirred at 750 rpm for 30 min) had shown a mean particle size
of ~326.8±15 nm, zeta potential of +28.2 ± 0.5 mV, and PDI of 0.21 ± 0.02. The encapsulation of
the clarithromycin slightly increased the polydispersity index, but the zeta potential of the unloaded
nanoparticles was not affected while the particle size increased. Under optimum conditions,
clarithromycin encapsulation efficiency into nanoparticles was found to be 70%. Additionally, chitosan-
tripolyphosphate nanoparticles were shown to be stable for a minimum of fifteen days in
deionized water at 4°C.

Conclusion::
The current study concludes the optimal conditions to formulate the chitosan nanoparticles
with optimal physicochemical characteristics.
Novel Noise Filter Techniques and Dynamic Ensemble Selection for
Classification
Authors: Nguyen Thi Ngoc A. , Nhu Quynh P. , Solanki Vijender K. 
Published: November 2020

Background:
Ensemble selection is one of the most researched topics for ensemble learning. Researchers have
been attracted to selecting a subset of base classifiers that may perform more helpful than the whole ensemble system
classifiers. Dynamic Ensemble Selection (DES) is one of the most effective techniques in classification problems. DES
systems obtain to select the most appropriate classifiers from the candidate classifier pool. Ensemble models that balance
diversity and accuracy in the training process improve performance than the whole classifiers.

Objective:
In this paper, the novel techniques are proposed by combining Noise Filter (NF) and Dynamic Ensemble
System (DES) to have better predictive accuracy. In other words, a noise filter and DES make the data cleaner and DES
improve the performance of classification.

Methods:
The proposed NF-DES model had been demonstrated on twelve datasets, especially has three credit scoring
datasets and a performance measure accuracy.

Results:
The results show that our proposed model has better than other models.

Conclusion:
The novel noise filer and dynamic ensemble learning with aim to improve the classification ability are
presented. To improve performance of classification, noise filter with dynamic ensemble learning makes the noise data
toward the correct class. Then, novel dynamic ensemble learning choose the appropriate subset classifiers in the pool of
base classifiers.
Use and Evaluation of Computerized Clinical Decision Support Systems for Early Detection of Sepsis in Hospitals: Protocol for a Scoping Review
Authors: Li Ling , Ackermann Khalia , Baker Jannah , Westbrook Johanna 
Published: November 2020

BackgroundSepsis is a leading cause of death in hospitals, with high associated costs for both patients and health care systems worldwide. Early detection followed by timely intervention is critical for successful sepsis management and, hence, can save lives. Health care institutions are increasingly leveraging clinical data captured in electronic health records for the development of computerized clinical decision support (CCDS) systems aimed at enhancing the early detection of sepsis. However, a comprehensive evidence base regarding sepsis CCDS systems to inform clinical practice, research, and policy is currently lacking.ObjectiveThis scoping review aims to systematically describe studies reporting on the use and evaluation of CCDS systems for early detection of sepsis in hospitals.MethodsThe methodology for conducting scoping reviews presented by the Joanna Briggs Institute Reviewer’s Manual and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) will be used and adapted as guides. A comprehensive literature search of 10 electronic databases will be conducted to identify all empirical quantitative and qualitative studies that investigate the use of CCDS systems for early detection of sepsis in hospitals. Detailed inclusion and exclusion criteria have been developed. Two reviewers will independently screen all articles based on these criteria. Any discrepancies will be resolved through discussion and further review by a third researcher if required.ResultsElectronic database searches have retrieved 12,139 references after removing 10,051 duplicates. As of the submission date of this protocol, we have completed the title and abstract screening. A total of 372 references will be included for full-text screening. Only 15.9% (59/372) of these studies were focused on children: 11.0% (41/372) for pediatric and 4.8% (18/372) for neonatal patients. The scoping review and the manuscript will be completed by December 2020.ConclusionsResults of this review will guide researchers in determining gaps and shortcomings in the current evidence base for CCDS system use and evaluation in the early detection of sepsis. The findings will be shared with key stakeholders in clinical care, research, policy, and patient advocacy.International Registered Report Identifier (IRRID)PRR1-10.2196/24899
PEMINDAHAN ARSIP INAKTIF DARI DUA DIREKTORAT JENDERAL KE UNIT KEARSIPAN (RECORD CENTER ) DI KEMENDIKBUD RI
Authors: Rumisyahdina Herdila , Lawanda Ike Iswary 
Published: November 2020

Records [I1] in the structure of government institutions support the work of the secretariat and administrative agencies. One such government agency is the Ministry of Education and Culture of the Republic of Indonesia (Kemendikbud RI). The records created is a proof of activity. If the records is not disposaled , it will cause accumulate in a room. Therefore, inactive records transfer is one of the efforts to disposal the records in the Ministry of Education and Culture. This study aims to identify the process of transfer of inactive records within the Ministry of Education and Culture. This research is a qualitative research with a descriptive approach. The data collection method was conducted by interviewing four archivists who contributed in the transfer of active records at the Ministry of Education and Culture through whatsapp and document analysis. The informants consists of two archivists from Unit Kearsipan Direktorat Jenderal and two archivists from Unit Kearsipan Kementerian. This research describes the transfer of inactive records consisting of preparation, acceptance, storage, and making a list of records. The results of this research are carried out in stages from Unit Pengolah to Unit Kearsipan Direktorat Jenderal, then Unit Kearsipan Direktorat Jenderal to Unit Kearsipan Kementerian. The transfer of inactive records at the Ministry of Education and Culture in general is in accordance with the applicable operational procedures, namely the Ministry of Education and Culture's Standard Operating Procedures in 2018 about transfer inactive records from the Unit Pengolah to the ministry's records center.
Encocaos con papa, ¿otro etnoboom usurpador?
Authors: Arocha Jaime 
Published: November 2020

Este ensayo interroga el porvenir de las comidas tradicionales del afropacífico dentro del etnoboom que Colombia experimenta. Define a ese fenómeno como la hiperexaltación y sobre-simplificación de los patrimonios simbólicos de los pueblos étnicos del país, con posibles efectos de canibalización, coincidentes con la expropiación territorial violenta de esos pueblos. Como esta coyuntura interpela a la ética antropológica, acude al profesionalismo de dos pioneros de la antropología de la comida en Colombia, Esther Sánchez y Ramiro Delgado, quienes coinciden en que parte de la respuesta está en acciones pedagógicas sobre el vínculo entre la comida de un pueblo y sus sistemas agrícolas, estéticos y simbólicos, opción que figura en varias disidencias gastronómicas quienes también rechazan los monocultivos industrializados.
Using the WRF Model to Refine NCEP CFSv2 Reanalysis Atmospheric Profile: A Southern Brazil Test Case
Authors: Diaz Lucas Ribeiro , Rolim Silvia Beatriz Alves , Santos Daniel Caetano , Käfer Pâmela Suélen , Rocha Nájila Souza da , Alves Rita de Cássia Marques 
Published: November 2020

ABSTRACT. The vertical distribution of atmospheric parameters is pivotal to understand atmospheric dynamic processes. This study analyzes the use of the Weather Research and Forecasting (WRF) model to generate atmospheric profiles as an alternative for a local radiosonde. We performed simulations in the WRF model for two dates with distinct weather conditions (01/09/2018 – cloudy and 03/14/2018 – clear-sky). The simulated data were compared with radiosondes launched in the study area, both (i) along the entire profile and (ii) with focus on the Planetary Boundary Layer (PBL) – for the variables water vapor mixing ratio (q), potential temperature (θ) and wind speed (Speed). The results showed a high correlation between the simulated and observed profiles, with most R values higher than 0.9. Bias and RMSE, respectively, ranged between -1.29 – 0.66 g/kg and 0.48 – 2.01 g/kg for q; -0.52 – 0.25 K and 0.44 – 3.00 K for θ; and -0.20 – 1.31 m/s and 1.61 – 2.77 m/s for Speed. The difference between the profiles from different WRF nested grids was minimal, suggesting that a resolution of approximately 12 km is enough to a good trade-off between detailing and computational cost. WRF model seems suitable to simulate fine atmospheric profiles.Keywords: vertical profiles, numerical weather prediction, meteorology, remote sensing, planetary boundary layer. Uso do Modelo WRF para refinar perfis atmosféricos de reanálise NCEP CFSv2: um estudo de caso no Sul do BrasilRESUMO. A distribuição vertical dos parâmetros atmosféricos é fundamental para entender os processos dinâmicos da atmosfera. Este estudo analisa o uso do modelo Weather Research and Forecasting (WRF) na geração de perfis atmosféricos, como uma alternativa à radiossondagens locais. Foram realizadas simulações com o WRF para duas datas em condições de tempo distintas (09/01/2018 – alta nebulosidade e 14/03/2018 – céu claro). Os dados simulados foram comparados com radiossondagens lançadas na área de estudo, (i) ao longo de todo o perfil e (ii) com foco na camada limite planetária (PBL) – para as variáveis razão de mistura do vapor de água (q), temperatura potencial (θ) e velocidade do vento (Speed). Os resultados mostraram uma alta correlação entre os perfis simulados e observados, com a maioria dos valores de R superiores a 0,9. Viés e RMSE, respectivamente, variaram entre -1,29 – 0,66 g/kg e 0,48 – 2,01 g/kg para q; -0,52 – 0,25 K e 0,44 – 3,00 K para θ; e -0,20 – 1,31 m/s e 1,61 – 2,77 m/s para Speed. Mínimas diferenças entre os perfis das diferentes grades aninhadas sugerem que uma resolução horizontal de aproximadamente 12 km é um bom balanço entre detalhamento e custo computacional. O WRF mostrou potencial na simulação de perfis atmosféricos refinados.Palavras-chave: perfis verticais, previsão numérica do tempo, meteorologia, sensoriamento remoto, camada limite planetária.
PENGARUH PENGGUNAAN MODEL PICTURE AND PICTURE TERHADAP KETERAMPILAN MENULIS TEKS CERITA FANTASI SISWA KELAS VII SMP NEGERI 7 PARIAMAN
Authors: Aldrina Inayyah , Abdurrahman Abdurrahman 
Published: November 2020

ABSTRACT The purpose of this study consists of three. First, it describes the writing skills of fantasy text for grade VII Junior High School 7 Pariaman before using the picture and picture models. Secondly, it describes the writing skills of fantasy text of grade VII Junior High School 7 Pariaman using a picture and picture models. Third, describe the effect of using picture and picture models against writing fantasy text skills grade VII Junior High School 7 Pariaman. This type of research is quantitative research with experimental methods. The design of this research is one group pretest-posttest design. The results of this study are three. First, the fantasy text writing skills of grade VII Junior High School 7 Pariaman before using the picture and picture model are in the Almost Enough qualification with an average score of 52.99. Secondly, the skill of writing fantasy text for grade VII Junior High School 7 Pariaman after using the picture and picture model is in the qualification More Than Enough with an average count of 69.53. Third, based on the t-test, the alternative hypothesis (H1) is at a significant level of 95% and the degree of freedom (dk) = n-1 because tcount > t table, which is 4.59 > 1.70. Kata Kunci: pengaruh, model picture and picture, menulis teks cerita fantasi
BLENDED LIBRARIAN, KONSEP DAN STRATEGI DALAM PEMENUHAN KEBUTUHAN INFORMASI MASYARAKAT BERBASIS SMART CITY
Authors: Oktaviana Dina 
Published: November 2020

Smart City, diterapkan di beberapa Kota di Indonesia. Tata pemerintahan ini menggunakan teknologi sebagai piranti utama, membuat tata pemerintahan elektronik, model jaringan, pembelajaran dan perpustakaan berbasis digital. Perpustakaan dituntut untuk menyediakan informasi sesuai disesuaikan dengan teknologi yang tersedia. Pustakawan juga harus mengembangkan keterampilannya untuk memaksimalkan layanan yang akan di berikan. Blended librarian adalah konsep dalam ilmu perpustakaan untuk pustakawan yang sangat tepat diterapkan pada kondiai masyarakat berbasis smart city. Konsep dan strategi penerapan blended librarian sudah ada di beberapa negara. Untuk itu dalam penelitian ini, kajian dilakukan pada beberapa artikel guna mengekstraksi konsep dan strategi blended librarian yang cocok di implementasikan pada kondisi masyarakat berbasis smart city
De cómo romper el cántaro
Authors: Rivas Herencia Eugenio 
Published: November 2020

Ante la proposición de una escultura del vacío en la obra de Miguel Berrocal, estudiamos las influencias del pensamiento oriental en el trabajo del escultor y profundizamos en las referencias a través de las que se filtraría en su trabajo el interés por esta noción escurridiza que escapa al entendimiento occidental y a su expresión plástica.Nos acercamos a quien fuera su maestro, Ángel Ferrant; al introductor del hueco en la escultura británica del siglo XX, Henry Moore; y a sus coetáneos, Oteiza y Chillida, máximos representantes de una escultura del vacío en nuestro país. El cierre de esta problemática, para asumir otros retos, supone en Berrocal la clausura y abandono de esta cuestión irresoluble. Con esta liquidación deja de lado un desafío superior que no volverá a afrontar de manera comprometida, aunque se filtrará para siempre en su manera de entender el espacio escultórico.
PRODUKSI DAN PRODUKTIVITAS TUNA OLEH KAPAL TUNA LONGLINE YANG BERBASIS DI PPN PALABUHANRATU
Authors: Imron Mohammad , Yusfiandayani Roza , Baskoro Mulyono S. 
Published: November 2020

Produktivitas penangkapan tuna dapat dilihat dari produksi penangkapan yang didaratkan di pelabuhan (landing) per upaya penangkapan (effort). Pelabuhan Perikanan Nusantara (PPN) Palabuhanratu menjadi salah satu pelabuhan perikanan yang aktivitas perikanannya tergolong aktif di wilayah pesisir selatan Pulau Jawa dan menjadi salah satu pusat kegiatan perikanan tangkap di wilayah Propinsi Jawa Barat. Produksi ikan tuna di PPN Palabuhanratu mengalami peningkatan yang cukup signifikan dari tahun 2010 sampai tahun 2019. Pada tahun 2014-2018 produksi ikan tuna di PPN Palabuhanratu mengalami penurunan yang cukup drastis. Pada tahun 2019, produksi kembali meningkat menjadi 1,091,612 ton. Landing Per Unit Effort (LPUE) digunakan dalam penelitian perikanan untuk mengindikasikan kelimpahan sumberdaya yang digunakan untuk melakukan stock assessment ketika mengestimasi kelimpahan relatif dari suatu spesies yang dieksploitasi. Komposisi hasil tangkapan tuna oleh kapal tuna longline terdiri atas ikan tuna sirip kuning (Thunnus albacores), tuna mata besar (Thunnus obesus), ikan tuna albakor (Thunnus alalunga). Produksi tuna yang didaratkan di PPN Palabuhanratu dari tahun 2010-2019 mengalami fluktuasi. Pada tahun 2010 produksi ikan tuna sirip kuning sebesar 444,952 ton, ikan tuna mata besar sebesar 979,189 ton, ikan tuna albakor sebesar 122,671 ton. Pada tahun 2019 produksi ikan tuna sirip kuning sebesar 617,992 ton, ikan tuna mata besar sebesar 240,487 ton, ikan tuna albakor sebesar 233,133 ton. Produktivitas tertinggi terjadi pada ikan tuna sirip kuning tahun 2014 dengan nilai LPUE sebesar 6,09 dengan produksi sebesar 2,448,171 ton dengan jumlah effort 402. Produktivitas mengalami fluktuasi setiap tahunnya.