bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postpartum psychosis in peripartum cardiomyopathy: a case report
Authors: Owuor Odhiambo Henry , Akiruga James Amisi , Laktabai Jeremiah , Ateya Samuel , Omar Salwa Mohamed 
Published: March 2020

Abstract
Background
This case report highlights the rare occurrence of postpartum psychosis in the setting of peripartum cardiomyopathy, which can have rare presentations like arrhythmias and pulmonary edema; and the challenges one should anticipate while managing these conditions together. Caution is advised whenever antipsychotic drugs are to be administered to a patient with a cardiac condition as these drugs potentially increase the risk of arrhythmias and sudden death.

Case presentation
A 35 year old grand multiparous woman who was 1 week into puerperium was admitted with severe difficulty in breathing at rest, chest congestion and pain. She also had easy fatigability, orthopnea, paroxysmal nocturnal dyspnea, edema, tachycardia, tachypnea, irregularly irregular heart rate with a pulse deficit, elevated jugular venous pressure, cardiomegaly, hepatomegaly and pulmonary crepitations. On the sixth day while improving on standard drugs for heart failure, she developed bizarre behavior and confusion. She also had auditory, visual and olfactory hallucinations; violence to the baby and the husband; and refusal to feed and take medication. There was no altered sensorium and the vital signs were normal. She was diagnosed with puerperal psychosis during the management of peripartum cardiomyopathy.

Conclusion
In the rare occurrence of puerperal psychosis in the course of management of peripartum cardiomyopathy one must be acutely aware of the risk of sudden cardiac death occasioned by use of antipsychotics, either directly or due to arrhythmias. Continuous electrocardiogram (ECG) monitoring or use of alternative management modalities is thus highly advised.
Study protocol of a multicenter randomized controlled trial of mindfulness-based intervention versus relaxation to reduce emotional exhaustion in medical students in France: the “Must prevent” study
Authors: Baeza-Velasco Carolina , Genty Catherine , Jaussent Isabelle , Benramdane Myriam , Courtet Philippe , Olié Emilie 
Published: March 2020

Abstract
Background
Medical students are exposed to an emotionally exhausting training/work environment and to stressful academic demands. Consequently, psychopathologies, burnout and suicidal ideation are frequent in this population. These factors can also affect their empathy and quality of care. Therefore, the development and implementation of programs to promote resilience to stress specifically in medical students and the evaluation of their efficiency are a priority. Here, we describe the protocol of the first French study to assess the long-term effectiveness and acceptability of a mindfulness-based intervention (MBI) compared with relaxation training (RT) to reduce emotional exhaustion in medical students.

Methods
This multicenter randomized controlled trial (“Must prevent”) plans to enroll 612 students in the fourth and fifth year of medical studies from nine French universities. After inclusion, they will be assigned randomly to the MBI or RT group. Both interventions are structured around an 8-week program that includes one group class per week and daily at-home exercises. The primary endpoint is the emotional exhaustion score assessed with the Maslach Burnout Inventory at month 12 of the follow-up. Secondary endpoints include anxiety-depressive symptomatology, suicidality, psychoactive substance use, depersonalization, psychological and physical pain, empathy, emotional regulation, self-compassion, mindfulness, quality of life, and program acceptability. Evaluations will be done before and immediately after the 8-week intervention, and at month 6 and 12 of the post-intervention follow-up.

Discussion
If the proposed interventions are well accepted and useful to decrease negative emotions and/or increase wellbeing among medical students, they should be disseminated among this population and even included as part of the training on emotional skills needed for the routine medical practice.

Trial registration
This trial is registered under the number NCT04026594 (July 18, 2019).
Psychosocial and clinical factors associated with depression among individuals with diabetes in Bahir Dar City Administrative, Northwest Ethiopia
Authors: Abate Teshager Woldegiorgis , Gedamu Haileyesus 
Published: March 2020

AbstractBackgroundIn a context of the potential epidemic nature of both diabetes mellitus (DM) and depression had negative effects in cases of disability and mortality. Coexisting depression had been linked to morbidity and mortality in people with diabetes. Therefore, this study aimed to identify psychosocial and clinical factors associated to develop depression symptoms in diabetes patients.MethodsA systematic institution based cross-sectional study design was conducted from 1st March to 8th April 2016 among adult diabetes patent. Depression status was assessed by the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed by logistic regression and at P < 0.05 with 95% CI was considered statistically significant.ResultA total of 416 patients were included in this studied. Based on PHQ-9, self- reported depression symptom was 29.3% [95% CI 25.2, 33.4]. In the performed statistical evaluation, patients whose age was between 45 and 54 years old (AOR = 3.88; 95% CI 1.36, 11.08); being female (AOR = 2.43; 95% CI 1.29, 4.58); who has poor social support (AOR = 6.08; 95% CI 2.98, 12.40); and who has high fear of kidney problems secondary to DM (AOR = 6.12; 95% CI 1.75, 21.23) were statistically associated with depressive symptoms in diabetes patients.ConclusionThis study demonstrated that complication fears, social support, being female and sexual dysfunction were found significantly associated with co-morbid depression in diabetes. Therefore, availed a social network of family and friends; providing diabetes education to address the patient’s fear of complications; and considered a sexual function is an integral part of overall health in diabetic patients.
Comparison between simple triage and rapid treatment and Taiwan Triage and Acuity Scale for the emergency department triage of victims following an earthquake-related mass casualty incident: a retrospective cohort study
Authors: Lin Yun-Kuan , Niu Kuang-Yu , Seak Chen-June , Weng Yi-Ming , Wang Jen-Hung , Lai Pei-Fang 
Published: March 2020

Abstract
Background
Triage plays a crucial role in the emergency department (ED) management of mass casualty incidents (MCIs) when resources are limited. This study aimed to compare the performance of simple triage and rapid treatment (START) with that of the Taiwan Triage and Acuity Scale (TTAS) for the ED triage of victims following an earthquake-related MCI.

Methods
We retrospectively reviewed the records of victims presenting at our ED with earthquake-related injuries within 24 h of a large-scale earthquake. TTAS was initially used at our ED for this event, and START was performed by retrospectively reviewing the patient records in a blinded manner. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of START and TTAS were determined for predicting ED discharge.

Results
We enrolled 105 patients (predominantly women, 60.0%; median age, 45.0 years) in this study; most of them presented with traumatic injuries and were initially triaged as TTAS level III (78.1%), followed by TTAS level II (11.4%). Although the majority of the victims (81.0%) were discharged, four deaths occurred. A moderate agreement in differentiating emergency from nonemergency patients was observed between START and TTAS. Furthermore, both the triage systems showed similar predictions for ED disposition (START AUC/sensitivity/specificity: 0.709/82.35%/55.00%; TTAS AUC/sensitivity/specificity: 0.709/90.59%/45.00%).

Conclusions
The present study demonstrated that START and TTAS have similar triage accuracy and ability to predict ED disposition. Our findings demonstrate that START may be used as an alternative to TTAS for the ED triage of victims following earthquake-related MCIs.
Transcriptome profiling of pluripotent pig embryonic stem cells originating from uni- and biparental embryos
Authors: Choi Kwang-Hwan , Lee Dong-Kyung , Oh Jong-Nam , Kim Seung-Hun , Lee Mingyun , Kim Sung Woo , Lee Chang-Kyu 
Published: March 2020

Abstract
Objectives
Pig pluripotent stem cells have tremendous potential because the pig is a valuable animal as both an agricultural resource and as a preclinical model of human therapy. To date, a lack of understanding of pig pluripotency has inhibited the derivation of embryonic stem cells (ESCs) and transgene-free induced pluripotent stem cells. Therefore, there has been no accessible or reliable transcriptome data for researching the genuine pig pluripotency network. Our previous study isolated authentic pig ESCs, which had teratoma-forming and direct differentiation ability, that were derived by activating the FGF2, ACTIVIN A, and WNT pathways. Here, we aimed to provide detailed information on transcriptome data of the newly derived pig ESCs and perform a comparative analysis with pig preimplantation embryo transcriptomes in a public database.

Data description
The transcriptome data of ESCs derived from in vitro fertilized and parthenogenetic embryos were generated by HiSeq 2500. Then, differentially expressed genes (DEGs) from each sample were compared with fibroblasts, and gene expression profiling was carried out for comparative analysis. Our data, as the first transcriptome dataset for genuine pig pluripotent cells, could be a general reference for explaining the molecular mechanism of species-specific pluripotency and improving understanding of the embryo development of domestic animals.
Dietary total antioxidant capacity significantly interacts with 6-P21 rs2010963 gene polymorphisms in terms of cardio-metabolic risk factors in patients with metabolic syndrome
Authors: Farhangi Mahdieh Abbasalizad 
Published: March 2020

Abstract
Objective
Gene- nutrient interaction might possibly be involved in the pathogenesis of metabolic syndrome and its components. In the current report, the association between antioxidant potential of the diet with 6P21 rs2010963 gene polymorphism in patients with metabolic syndrome has been evaluated. Two hundred fifty-four patients with metabolic syndrome were enrolled. Total dietary antioxidant capacity (TAC) has been estimated and anthropometric assessments were assessed. Biochemical assays including serum glucose, matrix metalloproteinase-3, liver enzymes and lipid profiles were also assessed. Polymerase chain reaction- restriction fragment length polymorphism (PCR–RFLP) method was used for determination of 6P21 rs2010963 polymorphism.

Results
Dietary vitamin E score was significantly higher in GC genotype compared with other genotypes (P = 0.035). Patients in CC genotype of 6P21 rs2010963 had significantly higher body mass index (BMI), fasting blood sugar and liver enzymes (P < 0.05). Being in the higher dietary TAC scores was also associated with lower liver enzymes. The interaction between 6P21 rs2010963 and dietary TAC significantly affected BMI, FBS and diastolic blood pressure (P < 0.05). According to our findings the CC genotype of 6P21 rs2010963 could be considered as the possible risk factor for obesity and metabolic disorders among patients with metabolic syndrome.
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells
Authors: Singh Neeru , Bhakuni Rashmi , Chhabria Dimple , Kirubakaran Sivapriya 
Published: March 2020

Abstract
Objective
Cisplatin, the most common chemotherapeutic drug for the treatment of advanced stage cervical cancers has limitations in terms of drugs resistance observed in patients partly due to functional DNA damage repair (DDR) processes in the cell. Mediator of DNA damage checkpoint 1 (MDC1) is an important protein in the Ataxia telangiectasia mutated (ATM) mediated double stranded DNA break (DSB) repair pathway. In this regard, we investigated the effect of MDC1 change in expression on the cisplatin sensitivity in cervical cancer cells.

Results
Through modulation of MDC1 expression in the cervical cancer cell lines; Hela, SiHa and Caski, we found that all the three cell lines silenced for MDC1 exhibited higher sensitivity to cisplatin treatment with inefficiency in accumulation of p γH2AX, Ser 139 foci and increased accumulation of pChk2 Thr 68 at the damaged chromatin followed by enhanced apoptosis. Further, we observed the increased p53 Ser 15 phosphorylation in the MDC1 depleted cells. Our studies suggest that MDC1 expression could be a key determinant in cervical cancer prognosis and its depletion in combination with cisplatin has the potential to be explored for the sensitisation of chemo-resistant cervical cancer cells.
Existence of solution for a quasilinear elliptic Neumann problem involving multiple critical exponents
Authors: Li Yuanxiao , Wang Xiying 
Published: March 2020

AbstractIn this paper, we study the Neumann boundary value problem to a quasilinear elliptic equation with the critical Sobolev exponent and critical Hardy–Sobolev exponent, and prove the existence of nontrivial nonnegative solution by means of variational method.
An analysis of a moderate earthquake, eastern flank of the Red Sea, Saudi Arabia
Authors: Abdelfattah Ali K. , Al-amri Abdullah , Sami Soliman M. , Zaidi Faisal K. , Qaysi Saleh , Fnais Mohamed , Almadani Sattam , Al-Arifi Nassir 
Published: March 2020

AbstractThe present study presents the analysis of a moderate earthquake (Mw 4.0) and its largest aftershocks located along the Red Sea coast, southwestern Saudi Arabia, with the aim to understand the enigma of peculiar seismicity in the Arabian Shield. We analyzed a high-quality waveform dataset collected from ten well-recorded earthquakes of moment magnitude ranging from 2.0 to 4.0 in order to determine the hypocenter locations and focal mechanisms. The focal mechanisms were retrieved from the regional moment-tensor inversion for the mainshock and using the P-wave polarities for the corresponding aftershocks of Mw ≥ 2.0, respectively. The focal mechanism solutions were inverted to retrieve the seismogenic stress using the stress tensor inversion. The combination of the nearby fault trends and the obtained results from hypocentral relocations, focal mechanism solutions, and stress tensor inversion emphasizes that the NE fault trend is likely to be the causative fault resulting in the 2017 Namas earthquake sequence, implying that the local tectonic setting is incompatible with the large-scale regional tectonics of the Red Sea opening. On the contrary, estimates of low-stress drops exhibit typical values compatible with those reported for the shallow plate-boundary earthquakes that occurred in the Red Sea, suggesting that the existing weak zones in the southernmost part of the Arabian Shield may be attributed to the large-scale regional tectonics of the Red Sea opening.
Bisphenol A enhances adipogenic signaling pathways in human mesenchymal stem cells
Authors: Salehpour Amin , Shidfar Farzad , Hedayati Mehdi , Neshatbini Tehrani Asal , Farshad Ali Asghar , Mohammadi Saeed 
Published: March 2020

AbstractBackgroundThe endocrine disruptor Bisphenol-A (BPA), has been involved in dysregulating adipose tissue development and increasing the risk of obesity. The objective of this experiment was to investigate whether treatment of human mesenchymal stem cells with BPA could modulate adipogenesis and adipocyte differentiation.MethodsIn this experimental study, the human adipose-derived mesenchymal stem cells (hASCs) were cultured for 2 weeks with continuous exposure to 10− 10 M or 10− 8 M concentrations of BPA. The extent of triglyceride accumulation was visualized by Oil Red O staining. To evaluate BPA effect on the expression levels of key adipogenic trascripotion factors and proteins, we used Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and ELISA.ResultsThe results presented a dose-dependent triglyceride accumulation in treated cells with BPA. Additionally, we observed that BPA induced transcription of the Peroxisome proliferator-activated receptor-gamma (PPARγ), CCAAT-enhancer-binding protein-alpha (C/EBPα), CCAAT-enhancer-binding protein-beta (C/EBPβ), sterol regulatory element-binding protein-1c (SREBP1c), Fatty acid synthase (FASN), and lipoprotein lipase (LPL); BPA suppressed the expression of Fatty acid binding protein-4 (FABP4) and Estrogen receptor-beta (ERβ).ConclusionsOur findings supported the hypothesis that BPA enhances adipogenic differentiation thereby may play a role in development of obesity and dysregulation of metabolic homoeostasis.
Evaluation of heritability of β-eudesmol/hinesol content ratio in Atractylodes lancea De Candolle
Authors: Tsusaka Takahiro , Makino Bunsho , Ohsawa Ryo , Ezura Hiroshi 
Published: March 2020

Abstract
Background
Atractylodes lancea De Candolle is a medicinal plant distributed in East Asia. Its rhizome has been used as an important crude drug in traditional Chinese and Japanese medicines for the treatment of numerous diseases and disorders. In recent years, the demand for mass production of the crude drug with a stable quality has increased. Its major active compounds are sesquiterpenoids, such as β-eudesmol and hinesol that have closely related chemical structures with each other. As the criteria for evaluating the quality of A. lancea, the β-eudesmol/hinesol content ratio is considered important. In A. lancea, the ratio could be considered to be influenced by genetic factors, geographical environment factors and these interactions. Few studies of a detail genetic analyses for β-eudesmol/hinesol content ratio have been reported. Therefore, we evaluated the heritability and genotype–environment interaction on the β-eudesmol/hinesol content ratio in A. lancea using clonal lines propagated with division of rhizome.

Results
The heritability of the β-eudesmol/hinesol content ratio in A. lancea was evaluated through the cultivation of clonal lines of A. lancea in both different years (2016, 2017) and locations (Hokkaido, Ibaraki). Correlations between β-eudesmol and hinesol contents were identified in all clonal lines, with high correlation coefficients (r = 0.73–0.99). The broad-sense heritability of the β-eudesmol/hinesol content ratio was revealed to be high at 0.92. The effects of cultivation year were smaller than that of genotype, and few genotype–environment interactions were observed. In addition, the influence of cultivation location was also smaller than that of genotype, and the correlation between the two cultivation locations on the β-eudesmol/hinesol content ratio was high. The results suggested that the β-eudesmol/hinesol content ratio in A. lancea is highly dependent on genetic factors.

Conclusion
We demonstrate that the heritability of β-eudesmol/hinesol content ratio is high and that the effects of genetic factors were stronger than that of environmental factors such as cultivation location and year. Our findings suggested that selective breeding and clonal propagation are effective strategies for the production of A. lancea with stable qualities for use in the production of crude drugs.
Thyroid cancer and post thyroidectomy tracheomalacia: algorithm for decoding a diagnostic dilemma!
Authors: Shah Shagun B. , Kulkarni A. 
Published: March 2020

AbstractAdult tracheomalacia can be caused by long standing goitre or malignant infiltration and has a high morbidity. We anticipated possibility of postoperative tracheomalacia (based on preoperative dynamic cervical sonography and radiographic evidence), in both the cases presented here. A high index of suspicion helped in timely detection of this complication. An algorithm to decode tracheomalacia is constructed here. Elective endotracheal tube (ETT) retention postoperatively, followed by a planned, trial tracheal extubation with gradual ETT withdrawal under bronchoscopic guidance in the OT, several days post-surgery was employed. ETT re-insertion followed by an elective tracheostomy was performed on bronchoscopic confirmation of tracheomalacia.
Randomized phase III study of adjuvant chemotherapy for high-risk, node-negative breast cancer (BC) comparing FAC with FAC followed by weekly paclitaxel: First efficacy analysis of the GEICAM/2003-02 trial.
Authors: Martin Miguel , Lluch Ana , Ruiz Amparo , Ruiz Borrego Manuel , Barnadas Agust , Gonzalez Sonia , Calvo Lourdes , Margeli Vila Mireia , Anton Antonio , Rodriguez-Lescure Alvaro , Seguí-Palmer Miguel Angel , Munoz-Mateu Montserrat , Dorca Ribugent Joan , Lopez-Vega Jose Manuel , Mendiola Fernandez Cesar , Andres Raquel , Plazaola Arrate , Rodriguez Cesar , Casas Maria Isabel , Carrasco Eva Maria ,   Spanish Breast Cancer Research Group GEICAM
Published: March 2020

1001 Background: Adjuvant weekly paclitaxel (wP) sequential to anthracyclines improves the outcome of operable node-positive BC patients (pts) [Sparano NEJM 2008, Martin BCRT 2009]; however, most BC pts are currently node-negative at diagnosis. The role of wP in these pts is not well established yet. Methods: Pts aged 18-70, with T1-T3/N0 operable BC and at least one high-risk St Gallen 1998 criteria (size >2 cm, hormone-receptor [HR] negative, grade 2/3, age <35 years,) were eligible. HER2+ pts were allowed, after 792 entered the trial, the study was amended to exclude them. Pts were stratified by site, menopausal status, nodal status diagnostic method (sentinel-node biopsy versus lymphadenectomy) and HR status and randomized to receive FAC x6 (500/50/500 mg/m2 every 3w) or FAC x4→wP x8 (paclitaxel 100 mg/m2 weekly). The primary endpoint was DFS. The trial was designed to detect an absolute 5-y DFS increase of 5% (80% FAC, 85% FAC→wP); a sample size of 1812 evaluable patients (906 per arm) was required to detect this difference (α=0.05, β= 80%). Assuming a drop-out rate of 6%, 1929 pts were required. The first analysis of DFS was planned when a median follow-up of 5 years was reached. Results: Between September 2003 and October 2008, 1925 pts (FAC 974, FAC→wP 951) were randomized. Patient characteristics were well balanced between arms, median age was 50, 73% of pts were HR positive and 9% HER2 positive. 97% of pts with FAC and 85% of pts with FAC→wP completed all treatment as planned. The median dose intensity was 98% with FACx6, 99% with FACx4 and 98% with wP. The most frequent grade 3-4 toxicities (>3% in either arm) with FAC vs FAC→wP were neutropenia (25% vs 22%) with 4% vs 3% of febrile neutropenia, fatigue (3% vs 8%), sensory neuropathy (0 vs 5%), and vomiting (4% in each arm). After a median follow-up of 5.3 years, the proportion of patients disease free is 93% and 90% with FAC→wP and FAC (HR for relapse 0.732, 95% CI: 0.542 to 0.990; log-rank p-value=0.0423). Conclusions: For pts with high-risk node-negative BC, adjuvant FAC→wP was associated with a small but significant improvement in DFS compared with FAC, with manageable toxicity.