bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic challenges in radiation-induced salivary gland cancers
Authors: Ronchi Sara , Mastella Edoardo , Vischioni Barbara , Bonora Maria , Orlandi Ester 
Published: December 2020

Purpose of review
To give an overview of recent advances in therapeutic approaches of radiation-induced salivary gland cancers (ri-SGCs).

Recent findings
Reirradiation with protons and carbon ions demonstrated to be feasible, safe and to offer good local control rates, with the possibility of overcoming radioresistance and dosimetric issues in previously irradiated cancer patients. Chromosomal rearrangements, gene fusions and expression profiles are important to identify specific cancer subtypes and can guide tailored systemic therapy.

Summary
Ri-SGCs are rare and heterogeneous. Patients are often heavily pretreated and at risk of toxicities, and their management remain challenging. A multidisciplinary approach in referral centers is mandatory. Knowledge about SGCs cellular and molecular mechanisms is constantly evolving. In the last years, novel advances in therapeutic approaches, such as carbon ion radiotherapy, are emerging as safe and effective options in active treatment, but further efforts are needed to offer tailored personalized treatments and to improve survival.
The dual pandemics of COVID-19 and racism: impact on early childhood development and implications for physicians
Authors: Brodie Nicola , Perdomo Joanna E. , Silberholz Elizabeth A. 
Published: December 2020

Purpose of review
The novel coronavirus (COVID-19) pandemic has highlighted healthcare and racial inequities. This article discusses recent literature documenting the impact of racism on early childhood development, disparities in access to developmental services and ways healthcare providers and health systems can promote physician well being during these difficult times.

Recent findings
Exposure to racism begins prenatally, and early childhood experiences with racism are intimately tied to adverse physical and mental health outcomes. Early intervention is key to treating children with developmental delay, but disparities exist in accessing eligibility screening and in the provision of services. Paediatric providers are at risk of developing secondary traumatic stress and burnout, which may affect the care that they provide.

Summary
New research has led to the development of resources that help paediatric providers address racism, access developmental resources in a novel manner and protect the paediatric workforce from trauma and burnout.
ADH5-mediated NO Bioactivity Maintains Metabolic Homeostasis in Brown Adipose Tissue
Authors: Sebag Sara C. , Zhang Zeyuan , Qian Qingwen , Li Mark , Harata Mikako , Li Wenxian , Zhu Zhiyong , Zingman Leonid , Liu Limin , Lira Vitor A. , Potthoff Matthew J. , Bartelt Alexander , Yang Ling 
Published: December 2020

SummaryBrown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status but the molecular mechanisms underlying this regulation are incompletely understood. ProteinS-nitrosylation, the nitric oxide-mediated cysteine thiol modification of proteins, plays important roles in cellular redox regulation. Here we show that both diet-induced obesity (DIO) and acute cold exposure elevates protein S-nitrosylation of BAT proteins, including UCP1, to regulate thermogenesis. This effect in BAT is regulated largely by S-nitrosoglutathione reductase (GSNOR, ADH5), a denitrosylase that balances the intracellular nitroso-redox status. Loss of ADH5 specifically in BAT impairs UCP1-dependent thermogenesis during acute cold challenge and worsens metabolic dysfunction during diet-induced obesity. Mechanistically, we demonstrate thatAdh5expression in BAT is controlled by the transcription factor heat shock factor 1 (HSF1) and administration of an HSF1 activator to the BAT of mice with DIO increasedAdh5expression and significantly improved UCP1-mediated mitochondrial respiration. Together, these data demonstrate that ADH5 controls BAT nitroso-redox homeostasis to regulate adipose thermogenesis which may be therapeutically targeted to improve metabolic health.HighlightsThermogenesis induces protein S-nitrosylation modification in the BAT;ADH5, a major cellular denitrosylase, is required for maintaining BAT metabolic homeostasis under both overnutrition and cold stress conditions;Diet-induced obesity suppresses HSF1-mediated activation ofAdh5in the BAT;ADH5 overexpression in BAT improves whole-body glucose homeostasis in obesity.
Metabolic allometry: A genomic approach to scaling
Authors: Fernandez-Gonzalez Mauricio A 
Published: December 2020

AbstractThe high complexity of living beings represents a difficult challenge to understand how different levels of organizations are interconnected, being especially difficult to identify how certain higher levels are affected by cellular dynamics. Important advances in ecology have shown that many phenomena can be explained through a power-law relationship, being the cellular metabolism a key component in this complexity networks scaling with a regular exponent related to body size and temperature. Here, using a novel approach we estimate the energy used to synthesize the portion of the genome that codes the metabolism searching for genomic scaling rules in five different species with higher differences in body sizes. We found that the energy of this genetic portion scales in a power-law relationship related to the mass of the species analyzed.
MoCpa1-mediated arginine biosynthesis is crucial for fungal growth, conidiation, and plant infection ofMagnaporthe oryzae
Authors: Aron Osakina , Wang Min , Wilfred Mabeche Anjago , Wajjiha Batool , Yang Shuai , You Haixia , Wang Zonghua , Tang Wei 
Published: December 2020

AbstractArginine is an important amino acid involved in processes such as cell signal transduction, protein synthesis, and sexual reproduction. To understand the biological roles of arginine biosynthesis in pathogenic fungi, we used Cpa1, the carbamoyl phosphate synthase arginine-specific small chain subunit inSaccharomyces cerevisiaeas a query to identify its ortholog inMagnaporthe oryzaegenome database and named it MoCpa1. MoCpa1 is a 471-amino acid protein containing the CPSase_sm_chain domain and the GATase domain. MoCpa1 transcripts were highly expressed at the conidiation, early-infection, and late-infection stages of the fungus. Targeted deletion ofMoCPA1gene resulted in the ΔMocpa1mutant exhibiting arginine auxotrophy on MM, confirming its role inde novoarginine biosynthesis. The ΔMocpa1mutant presented significantly decreased sporulation with some of its conidia being defective in morphology. Furthermore, the ΔMocpa1mutant was nonpathogenic on rice and barley leaves, which was a result of defects in appressorium-mediated penetration and restricted invasive hyphal growth within host cells. Addition of exogenous arginine partially rescued conidiation and pathogenicity defects on the barley and rice leaves, while introduction ofMoCPA1gene in ΔMocpa1mutant fully complemented the lost phenotype. Further confocal microscopy examination revealed that MoCpa1 is localized in the mitochondria. In summary, our results demonstrate that MoCpa1-mediated arginine biosynthesis is crucial for fungal development, conidiation, appressorium formation and infection-related morphogenesis inM. oryzae, thus serving as an attractive target for mitigating obstinate fungal plant pathogens.
Electro-conductive carbon nanofibers containing ferrous sulfate for bone tissue engineering
Authors: Nekounam Houra , Samadian Hadi , Asghari Fatemeh , Majidi Reza Faridi 
Published: December 2020

AbstractThe application of electroactive scaffolds can be promising for bone tissue engineering applications. In the current paper, we aimed to fabricate an electro-conductive scaffold based on carbon nanofibers (CNFs) containing ferrous sulfate. FeSO4·7H2O salt with different concentrations 5, 10, and 15 wt%, were blended with polyacrylonitrile (PAN) polymer as the precursor and converted to Fe2O3/CNFs nanocomposite by electrospinning and heat treatment. The characterization was conducted using SEM, EDX, XRD, FTIR, and Raman methods. The results showed that the incorporation of Fe salt did not induce an adverse effect on the nanofibers’ morphology. EDX analysis confirmed that the Fe are uniformly dispersed throughout the CNF mat. FTIR spectroscopy showed the interaction of Fe salt with PAN polymer. Raman spectroscopy showed that the incorporation of FeSO4·7H2O reduced the ID/IG ratio, indicating more ordered carbon in the synthesized nanocomposite. Electrical resistance measurement depicted that, although the incorporation of ferrous sulfate reduced the electrical conductivity, the conductive is suitable for electrical stimulation. Thein vitrostudies revealed that the prepared nanocomposites were cytocompatible and only negligible toxicity (less than 10%) induced by CNFs/Fe2O3fabricated from PAN FeSO4·7H2O 15%. These results showed that the fabricated nanocomposites could be applied as the bone tissue engineering scaffold.
Adaptation to host cell environment during experimental evolution of Zika virus
Authors: Grass Vincent , Hardy Emilie , Kobert Kassian , Talemi Soheil Rastgou , Décembre Elodie , Guy Coralie , Markov Peter V. , Kohl Alain , Paris Mathilde , Böckmann Anja , Muñoz-González Sara , Sherry Lee , Höfer Thomas , Boussau Bastien , Dreux Marlène 
Published: December 2020

AbstractZika virus (ZIKV) infection can cause important developmental and neurological defects in Humans. Type I/III interferon responses control ZIKV infection and pathological processes, yet the virus has evolved various mechanisms to defeat these host responses. Here, we established a pipeline to delineate at high-resolution the genetic evolution of ZIKV in a controlled host cell environment. We uncovered that serially passaged ZIKV acquired increased infectivity and simultaneously developed a resistance to TLR3-induced restriction. We built a mathematical model that suggests that the increased infectivity is due to a reduced time-lag between infection and viral replication. We found that this adaptation is cell-type specific, suggesting that different cell environments may drive viral evolution along different routes. Deep-sequencing of ZIKV populations pinpointed mutations whose increased frequencies temporally coincide with the acquisition of the adapted phenotype. We functionally validated S455L, a substitution in ZIKV envelope (E) protein, recapitulating the adapted phenotype. Its positioning on the E structure suggests a putative function in protein refolding/stability. Taken together, our results uncovered ZIKV adaptations to the cellular environment leading to accelerated replication onset coupled with resistance to TLR3-induced antiviral response. Our work provides insights into Zika virus adaptation to host cells and immune escape mechanisms.
A business process and portfolio management approach for Industry 4.0 transformation
Authors: Richard Sophie , Pellerin Robert , Bellemare Jocelyn , Perrier Nathalie 
Published: December 2020

PurposeThe purpose of this paper is to address the difficulties faced by manufacturing enterprises by providing a project portfolio management approach supporting the selection and prioritization of various Industry 4.0 projects where business process analysis is used to ensure the strategic alignment and value of the project portfolio.Design/methodology/approachThe design research methodology, a mixed applied research methodology, was used to develop and test the proposed approach.FindingsDespite the growing interest of the scientific and industrial communities in I4.0, it seems that there is no method by which manufacturing companies can select a large number of improvement projects. Moreover, studies tend to focus on the evaluation and implementation of a single technology, while the transformation of an intelligent plant requires the consolidation and coordination of many initiatives to achieve a global objective.Originality/valueThe proposed project portfolio management model offers support to enterprises during their digital transformation and improves their processes by integrating technology levers through consistent and achievable selection of I4.0 initiatives while meeting strategic goals and objectives.
A system dynamics approach to conceptualise causes of cost overrun of construction projects in developing countries
Authors: Asiedu Richard Ohene , Ameyaw Collins 
Published: December 2020

PurposeThis study aimed at developing and empirically testing a system dynamics causal loop (SDCL) model for investigating factors related to the risk of cost overruns, associated with the performance of construction projects in developing countries.Design/methodology/approachUsing data derived from the Ghanaian construction industry (GCI), a conceptual system dynamics model was hypothesised and empirically tested.FindingsSupported by empirical evidence, the study established that the low technical capacity of consultants is the underlying cause of cost overruns in government projects. There is a strong proof of the relationship between the results of the SDCL model and poor contract planning and supervision, change orders, competence of the project team and the lack of effective coordination amongst the contractual parties.Practical implicationsThe final SDCL model has revealed key risk components that would require standard mitigation measures in order to achieve “acceptable success” in construction projects.Originality/valueThe study presents an interactive approach for construction practitioners in developing countries to prioritise the causes of cost overruns in order to initiate quick responses.
Buy now before it expires: a study of expiration date-based pricing
Authors: Amr Yassin Cherouk , Soares Ana Maria 
Published: December 2020

PurposeFood waste and retail losses due to expiration dates are an important problem worldwide. Expiration date-based pricing (EDBP) is a price promotion technique consisting of charging different prices for perishable product approaching expiration date. The authors explore the influence of EDBP on impulse buying (IB) and on cognitive dissonance.Design/methodology/approachA mall intercept survey in Egypt was used to test the proposed model.FindingsThe results show that, while EDBP does not affect IB, it impacts cognitive dissonance. In addition, cognitive IB impacts cognitive dissonance, while affective IB does not.Practical implicationsResults suggest that there is a need to reconsider the effects of EDBP and call for alternative strategies to promote products approaching its expiration date, including strategies based on environmental protection by reducing waste arguments rather than on the sales promotional framework.Originality/valueIn spite of the importance of understanding consumer behaviour with perishable goods, this topic has taken little or no attention in the literature. The results provide useful insights for understanding EDBP.
Behavioral intention of “digital natives” toward adapting the online education system in higher education
Authors: Bag Sudin , Aich Payel , Islam Md. Aminul 
Published: December 2020

PurposeThe aim of the study is to examine the intention of students toward the online education system with emphasis on online examination in higher education. The study investigated different constructs that have an influence on the use of the online platform for learning to the specific domain that mitigates the personal needs of the learners outside the physical class boundaries.Design/methodology/approachData were collected through a self-administered structured questionnaire in a single cross-sectional survey from 430 students of higher educational institutions in India. The partial least square approach was used for path modeling to examine the relationships in the proposed research model using Smart PLS-3.3.2.FindingsAttitude, ease of use and usefulness have a significant relationship with the behavioral intention to use the online education system. However, nature of residential status, use of devices and use of network have an insignificant impact on the intention to use the online educational system.Research limitations/implicationsThough the study focused on the technology acceptance model (TAM) to examine the relationship in the proposed model, there is a need to consider the other constructs such as perceived behavioral control, past experience, etc. in future studies.Originality/valueThis paper identified the major determinants of students' intention to adapt to the online education system with special reference to the examination system and proposed a direction to encourage the higher education students to use online education as an alternate of physical classroom education.
Financial reporting under economic policy uncertainty
Authors: Ozili Peterson Kitakogelu 
Published: December 2020

Purpose
This paper aims to discuss financial reporting under economic policy uncertainty.

Design/methodology/approach
The paper uses discourse analysis to examine financial reporting under economic policy uncertainty.

Findings
The paper identifies the link between economic policy uncertainty and financial reporting, in terms of earnings management and fair value accounting. It argues that high economic policy uncertainty will transmit fewer new information to firms which can motivate managers to influence accounting numbers in the direction of the desired financial reporting outcome.

Originality/value
The relationship between economic policy uncertainty and financial reporting has not been studied. This paper is one of the first papers to relate economic policy uncertainty to financial reporting behavior.
Cultural intelligence and managerial relational performance: a resource advantage perspective
Authors: Egwuonwu Arthur , Sarpong David , Mordi Chima 
Published: December 2020

PurposeDrawing on the resource-advantage theory, the authors examine the effect of import managers' cultural intelligence (CQ) on their foreign counterpart's psychic distance and relational performance.Design/methodology/approachSurvey data collected from 228 Nigerian automobile import managers were analyzed using structural equation modelling (SEM) to examine the relationship among the study variables. The measure of CQ in this study comprises metacognitive and motivational CQs to examine the relations between metacognitive and motivational CQs on psychic distance and their ultimate effect on relational performance.FindingsThis study suggests that metacognitive CQ reduces the effect of psychic distance in buyer–seller exchange relationships, and in the presence of a low-level psychic distance, relational performance increases. Confirming the intervening role of CQ on performance relationship, the study highlights the role of CQ and its influence on psychic distance in facilitating (or impeding) relational exchanges in international buyer–seller transactions.Originality/valueThe authors present the concept of CQ as a human capital that has the potential to improve managerial relational performance. The authors go further to advance the potential significance and relevance of CQ in improving international buyer–seller exchanges.
Arab’s children’s influence on the buying process: comparing parent and child perceptions
Authors: Ghouse Suhail Mohammad , Chaudhary Monica , Durrah Omar 
Published: December 2020

Purpose
This paper aims to identify the perception levels of the child and parents towards the child’s influence on different product categories and stages of the family buying process in an Arab country Oman.

Design/methodology/approach
On the basis of the research gap identified from the literature, two separate bilingual questionnaires (parent and child) in English and local language (Arabic) were developed. The research commenced with a pilot study on 10 school students followed by contact with school authorities requesting to conduct a survey on school students 8–12 years of age and data collection through the survey on the students and their parents (either father/mother) during September-November, 2017–2018. Data analysis was made through an independent sample t-test and confirmatory factor analysis was made using AMOS 24.

Findings
A model was proposed incorporating three product categories as noisy, quiet and loud goods and perceptions of Arab parents and children were examined for the three stages of the family buying process. The findings of the study reveal that significant differences exist in child-parental perceptions on the child’s influence in the search, evaluation and final buying stages. The mean score among the three product categories was highest for noisy goods (Mean = 3.21, SD = 0.817) while in the case of buying stages, the mean of the final buying stage was highest (Mean = 2.11, SD = 0.514).

Research limitations/implications
More research studies are required in the Arab context, especially bringing in the social status of parents to justify their different shopping behaviours. This analysis is based on the perceptions of the tweenager segment, adding perceptions of the teenage segment could generate better research implications.

Practical implications
The research will serve as a base to consumer marketers in understanding distinct features of Arab tweenagers towards different products and will aid them in designing appropriate marketing strategies targeting parents and children in the Arab region.

Originality/value
After an extensive review of the consumer literature, it is assumed that almost no research study has been made examining parent-child perceptions towards the different product categories and buying stages targeting traditionally oriented families in the Arab region.
The effect of mindfulness on service encounter quality
Authors: Wang Emma Junhong , Berthon Pierre R. , Bechwati Nada Nasr 
Published: December 2020

PurposeThis paper aims to explore the effect of employees’ state mindfulness, a short period of mindful presence, on the quality of the service they provide in a service encounter.Design/methodology/approachThree studies are conducted. A pilot study explores the relationship between state mindfulness and service encounter quality. Experiment 1 examines whether a 15-min mindfulness exercise results in an increase in service employees’ state mindfulness. Experiment 2 tests whether induced state mindfulness produces higher service quality and whether a reminding technique can prolong state mindfulness between service encounters.FindingsThe results demonstrate the following. First, that more mindful employees provide better service quality. Second, that a short, easily implemented, mindfulness exercise can reliably increase employees’ state mindfulness. Third, induced mindfulness has an impact on subsequent service quality in terms of reliability, assurance, empathy and responsiveness. These effects persist regardless of the service encounter structure (high vs low structure) or the degree of emotional labor involved (high vs low emotionally charged). Finally, the reminding technique developed as part of this research suggests that state mindfulness can be maintained between service encounters.Research limitations/implicationsAs simulated (programmed) customers are used, independent evaluators to assess service quality are used. Service providers in this study are college students; future field studies should consider a wider range of service providers. The research focuses on state mindfulness; exploration of trait mindfulness offers future research opportunities.Originality/valueTo the best of the authors’ knowledge, this research is the first to empirically examine the link between mindfulness and service quality. It shows that mindfulness can be induced, and through a reminding technique be maintained, and improve service quality across service interactions. This is a powerful finding for marketing managers, for it offers a new method to enhance service provision. Moreover, this research implies that the increase in service quality is likely to be accompanied by reduced job burnout: a double win for employees, employers and customers.