bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO-128: Interrogating the role of race-related alternative splicing of SEMA3C in prostate cancer
Authors: Allen Tyler A. , Chandar Jay , Lacroix Bonnie L. , Patierno Steven R. , George Daniel J. , Freedman Jennifer A. 
Published: December 2020

Abstract
The age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are 1.6- and 2.4-fold greater, respectively, than among white men. These disparities likely result from a complex interplay among social, psycho-social, lifestyle, environmental, health system, and biological determinants of health. Despite the contribution of biological determinants of health, very few studies have utilized this population-based difference to identify the molecular mechanisms underlying race-related tumor aggressiveness. We have previously identified Semaphorin 3C (SEMA3C) as a novel alternatively spliced gene in PCa between AA and white patients. SEMA3C has been shown to be associated with increased cancer growth, poor prognosis in lung, breast, gastric, and ovarian cancers, and promotion of cell migration and invasion in PCa. To further study the significance of race-related skipping/inclusion of SEMA3C exon 19 in PCa cell biology, we used CRISPR/Cas9 technology to engineer a PCa cell line (DU145) expressing the SEMA3C variant skipping exon 19. Proliferation assays were performed with the established cell lines, and the SEMA3C exon 19 KO populations exhibited decreased proliferation rates, compared with the wild-type DU145 cells that express the SEMA3C variant including exon 19. These data suggest race-related alternative splicing of SEMA3C may have an impact on PCa aggressiveness in patients. Current and future experiments focus on interrogating the effect of race-related SEMA3C alternative splicing on PCa cell migration and invasion as well as in vivo tumor formation and metastasis. These findings will provide an increased understanding of the role of race-related alternative splicing in PCa disparities and potentially a new target for development of precision medicine interventions.
Citation Format: Tyler A. Allen, Jay Chandar, Bonnie L. Lacroix, Steven R. Patierno, Daniel J. George, Jennifer A. Freedman. Interrogating the role of race-related alternative splicing of SEMA3C in prostate cancer [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-128.
Abstract PO-143: Gender differences in dietary behavior and urinary gallic acid concentrations in racial minorities in New York City
Authors: Zambrano Cristina N. , Lu Wenyue , Johnson Cicely , Beeber Maayan , Panitz April , Ibrahim Safa , Fraser Marilyn , Ma Grace , Yeh Ming-Chin , Ogunwobi Olorunseun 
Published: December 2020

Abstract
Nutrition is important for cancer prevention. To investigate associations between dietary differences based on demographics and risk of cancer, we assessed dietary behavior and the urinary concentrations of gallic acid, an antioxidant found in various fruits and vegetables, in racial minorities in New York City (NYC). Ninety-one (91) participants were recruited from a senior center in East Harlem, NYC, a racially diverse and underserved community. A National Institute of Health (NIH) - validated diet survey questionnaire was used to collect dietary behavior data. Demographic and cancer information were also collected. All 91 participants completed the survey and forty-five (45) participants provided urine samples for gallic acid analysis. Associations between demographic factors and the intake of certain foods were assessed. Gender differences were significantly associated with dietary behavior and urinary gallic acid concentrations (UGAC). Female participants had a higher daily intake of fruits compared to male participants (p&lt;0.05). Additionally, female participants had significantly higher UGAC compared to male participants (p&lt;0.05). Other associations were also observed. Age was negatively associated with the quantity of french fries/fried potatoes and white potatoes intake (p&lt;0.05), while positively associated with frequency of fruit intake (p&lt;0.05). Furthermore, Asian race was associated with a higher frequency of fruit intake (p&lt;0.05), compared to other races. Among all recruited participants, we collected information on three cancer cases. Compared to non-cancer cases, participants with cancer reported a significantly lower fruit intake quantity (p&lt;0.05). In a multivariate analysis, we observed a significant association between fruit intake quantity and UGAC (p&lt;0.05) after controlling for income. Our findings suggest that gender differences in dietary behavior and UGAC may explain some of the gender differences in cancer incidence and prevalence observed in racial minority groups.
Citation Format: Cristina N. Zambrano, Wenyue Lu, Cicely Johnson, Maayan Beeber, April Panitz, Safa Ibrahim, Marilyn Fraser, Grace Ma, Ming-Chin Yeh, Olorunseun Ogunwobi. Gender differences in dietary behavior and urinary gallic acid concentrations in racial minorities in New York City [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-143.
Abstract PO-144: Assessment of diet and physical activity among prostate cancer survivors: Health Information National Trends Survey (HINTS)
Authors: Ezeani Adaora , Agurs-Collins Tanya 
Published: December 2020

Abstract
PURPOSE: Prostate cancer (PCa) is the third most common cancer diagnosis in US men. Evidence shows that diet and physical activity may play a role in decreasing the risk of PCa progression and improving outcomes. The purpose of this study is to explore lifestyle behaviors of men with and without prostate cancer. METHODS: Data were obtained from the NCI Health Information National Trends and Survey (HINTS), a cross-sectional, nationally representative survey. Using HINTS 5 Cycles 1-3, we identified US. males &gt; 50 years of age with PCa and those without a history of cancer.
Respondents reported their height, weight, daily fruit and vegetable intake, physical activity, sedentary behavior, and strength training. Data were weighted to calculate population estimates. Statistical analysis included frequencies and multivariate logistic regression analyses to examine the independent association of demographic factors with health behaviors. SPSS Statistics Version 26 was used to analyze data.
RESULTS: The overall weighted sample was 76.1% NHW (Non-Hispanic Whites), 64.3% post high school education, 38.6% &gt;$75,000 annual income, and 65.8% were married/cohabitating. PCa survivors were older compared to men without a history of cancer. Both PCa survivors and men without a history of cancer reported a BMI &gt;25, less than 150 minutes of moderate physical activity, less than 2 cups of fruit per day, and less than 3 cups of vegetables per day. Compared to men without cancer, PCa survivors were less likely to consume 3 cups of vegetables per day (OR 0.23, 0.08 – 0.63, p &lt;0.01) and less likely to complete more than 2 days of strength training per week (OR 0.47, 0.23 – 0.99, p&lt;0.05), adjusting for age, income, and ethnicity. CONCLUSIONS: Results suggest both PCa survivors and men without cancer do not follow diet and physical activity recommendations. There is a need to develop interventions to encourage healthy behaviors, especially strength training among PCa survivors.
Citation Format: Adaora Ezeani, Tanya Agurs-Collins. Assessment of diet and physical activity among prostate cancer survivors: Health Information National Trends Survey (HINTS) [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-144.
Abstract PO-188: Racial differences in healthcare utilization among lung cancer patients using immune checkpoint inhibitors: A population-based analysis
Authors: Nikita Nikita , Banks Joshua , Keith Scott W. , Johnson Jennifer M. , Wilson Melissa , Sharma Swapnil , LuYao Grace 
Published: December 2020

Abstract
Introduction: Although Immune checkpoint inhibitor (ICI) use for lung cancer has rapidly expanded, racial differences and their impact on clinical outcomes has been under-studied. This study addresses a crucial public health priority by evaluating racial disparities in healthcare utilization among patients with lung cancer receiving ICIs. Methods: We utilized the SEER-Medicare linked database with older adult patients (aged ≥65 years) with a diagnosis of lung cancer receiving ipilimumab (ipi), nivolumab (nivo), pembrolizumab and ipi/nivo in combination. Healthcare utilization was defined as emergency room (ER) and non-ER hospitalizations following ICI initiation. Hospitalization events were modeled by Cox proportional hazards regression using the counting process style of input (to incorporate repeated events) to assess the relative risk (RR) of hospitalization by race. The covariates used in the model were age at first ICI, sex, marital status, year of diagnosis, and Charlson comorbidity status. Results: We identified 4,091 lung cancer patients receiving ICIs; of which 3,451 were White, 350 were Black, and 290 were Asian. Following ICI initiation after adjusting for potential confounding, Asians were 13% less likely to experience ER hospitalization than Whites (RR: 0.87, 95% CI: 0.77-0.98; p=0.027), and Blacks were 22% more likely than Whites to experience ER hospitalization (RR: 1.22, 95% CI: 1.10-1.35; p&lt;0.001). For non-ER hospitalization after adjusting for potential confounding, Asians were 38% less likely than Whites to experience non-ER hospitalization (RR: 0.62, 95% CI: 0.45-0.84; p=0.002), however, Blacks were not significantly different from Whites (RR: 0.95, 95% CI: 0.75-1.21; p=0.67). Conclusion: This retrospective observational study is the first to show the racial differences in healthcare utilization among lung cancer patients receiving ICIs. Although ICI use is markedly increasing, our results could suggest that some populations do not experience their benefits equally. Further studies are warranted to validate the study results about the increase in ER and non-ER hospitalizations among blacks.
Citation Format: Nikita Nikita, Joshua Banks, Scott W. Keith, Jennifer M. Johnson, Melissa Wilson, Swapnil Sharma, Grace LuYao. Racial differences in healthcare utilization among lung cancer patients using immune checkpoint inhibitors: A population-based analysis [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-188.
Abstract PO-206: Influence of social determinants of health on timeliness to treatment for metastatic HCC and the impact of Affordable Care Act
Authors: Jayakrishnan Thejus , Bakalov Veli , Finley Gene , Monga Dulabh , Wegner Rodney 
Published: December 2020

Abstract
Background While we strive for progress in treatment and outcomes, it is imperative that disparities driven by socioeconomic factors are also recognized and addressed. We hypothesized that social determinants of health may predict delay in systemic therapy for metastatic hepatocellular carcinoma patients (HCC) and sought to examine the impact of Affordable Care Act (ACA). Methods National Cancer Database (NCDB) was queried for patients with metastatic hepatocellular carcinoma diagnosed from 2004-2015 and considered for first line systemic therapy within 6 months (180 days) of diagnosis. Time to initiation (TTI) was defined as time in days(d) from diagnosis of cancer to initiation of systemic therapy. Survival was measured in months(m) from the day of diagnosis. Multivariate analyses was performed using 2010 as cut-off between pre- and post-ACA for analysis. Results 630 patients meeting the eligibility criteria. Median TTI in the group was 57d. Only factor associated with delayed TTI (defined as forth quartile of TTI) in a multivariate logistic regression was non-Hispanic Black (NHB) race Odds Ratio OR 1.94(95%CI 1.0–3.3), p-value=0.052.
The OR showed improvement with implementation of ACA – OR3.6(95%CI 1.4-9.4),p- value 0.008 during pre-ACA vs. 1.3(0.5-3.1),p-value=0.6 post-ACA. There were non- significant trend towards higher mortality among NHB vs. NHW (HR 1.2, 95% CI 1.0- 1.6) and lower mortality for those insured vs. uninsured (HR 0.8, 95% CI 0.5-1.1.
Conclusion Race appears to impact timeliness to therapy in metastatic HCC patients and was positively impacted by ACA. Continued research to monitor disparities in care and identify underlying mechanisms to mitigate them are warranted.
Citation Format: Thejus Jayakrishnan, Veli Bakalov, Gene Finley, Dulabh Monga, Rodney Wegner. Influence of social determinants of health on timeliness to treatment for metastatic HCC and the impact of Affordable Care Act [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-206.
Abstract PO-212: Disparities in the enrollment to systemic therapy and survival for patients with multiple myeloma
Authors: Jayakrishnan Thejus , Bakalov Veli , Chahine Zena , Lister John , Wegner Rodney , Sadashiv Santhosh 
Published: December 2020

Abstract
Background The treatment options in Multiple Myeloma (MM) are variable and may involve combinations of chemotherapy, immunomodulatory therapy, monoclonal antibodies and stem cell transplant. In the present study, we hypothesized that socioeconomic factors impact the treatment and survival of patients with MM who receive systemic therapy as firstline treatment. Methods We queried the National Cancer Database (NCDB) for patients with MM (ICD-0-3 code 9732) diagnosed from 2004-2016. We included only that received systemic therapy as first line treatment. Active MM patients were defined as those treated within 120 days of diagnosis.
Enrollment rates were calculated as receipt of primary therapy as the incident-event (numerator) over time-to-initiation of therapy or TTI (denominator) and used to calculate incident-rate ratios that was further analyzed using Poisson regression analysis- reported as enrollment-rate ratios (ER, &lt;1 indicating lower enrollment rate). Multivariate Cox-proportional hazard model was performed for survival analysis and reported as calculate Hazard Ratios (HR). IQR=Interquartile range. Results We identified 56,102 patients for enrollment analysis and 50,543 for survival analysis respectively. Median age was 69 (IQR 60-77) years and included 55% males. Overall rate of enrollment to systemic therapy was 42.3 per 1000 person days, mean TTI was 17d (range 6-66d) and median overall survival was 33.4 (11.2-73.5) months. Therapy enrollment in a multivariate model was significiantly impacted by race and gender (p-value&lt;0.005). Advanced age, earlier year of diagnosis, lack of insurance or medicaid insurance, higher comorbidity were associated with higher mortality (HR&gt;1, p-value&lt;0.005) while female gender, non hispanic black race, higher income and treatment at academic center were associated with lower mortality (HR&lt;1, p- value&lt;0.005). Conclusion Study suggests that multiple myeloma patients treated with systemic therapy as first line represent a vulnerable section of the patients and disparities in terms of socioeconomic characteristics exist in the treatment and outcomes.
Citation Format: Thejus Jayakrishnan, Veli Bakalov, Zena Chahine, John Lister, Rodney Wegner, Santhosh Sadashiv. Disparities in the enrollment to systemic therapy and survival for patients with multiple myeloma [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-212.
Abstract PO-218: Molecular profiling of basal 2 subtypes of triple negative breast cancer cells and their response to a histone deacetylase inhibitor
Authors: Word Beverly , Cotton Ebony , Hammons George , Lyn-Cook Beverly , Stovall Density 
Published: December 2020

Abstract
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that often strikes young women, particularly minority women in their reproductive years. This cancer is very aggressive and has a poor prognosis mainly, due to the lack of effective chemotherapeutic agents. Recently, molecular profiling of a patients’ tumors yielded detection of specific driver genes in primary tumors that resulted in the use of a single or combination therapies targeting those driver genes. Triple negative breast cancers present an additional problem, in that they are found in different forms or subtypes histologically and molecularly. Basal 2 subtype is one of the most aggressive form of TNBC. Studies have shown that histologically designated tumors yield different treatment results. This study examined the molecular profiles of two Basal 2 triple negative breast cancers representing two different African American women and their response to vorinostat. Using a RT2 Profiler PCR gene expression array, vorinostat was found to up-regulate 54 genes and downregulated 3 genes in HCC70 TNBC. In HCC1806, 23 genes were upregulated and 38 downregulated. The most significant changes in gene expression were noted in CCND2 expression.
Changes were also noted in SNA12, SERPINE, SLC39A6, AR, BRAC1 and TWIST. In HCC1806, significant changes in gene expression were noted in ABCB1, CCND2, CDKN1C and MMP9. Up-regulation of CCND2 was observed in both basal 2 cell lines. CCND2 encodes cyclin D2 in which low expression is associated with poor prognosis. Understanding individual differences in cancer driver genes will greatly improved personalized medicine in triple negative breast cancer.
Citation Format: Beverly Word, Ebony Cotton, George Hammons, Beverly Lyn-Cook, Density Stovall. Molecular profiling of basal 2 subtypes of triple negative breast cancer cells and their response to a histone deacetylase inhibitor [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-218.
Abstract PO-220: Comprehensive "omic" portraits of breast cancer in Mexican-Hispanic women
Authors: Romero-Cordoba Sandra Lorena , Salido-Guadarrama Ivan , Rebollar-Vega Rosa , Tenorio-Flores Alberto , Bautista-Piña Verónica , Villegas-Carlos Felipe , Dominguez-Reyes Carlos , Hidalgo-Miranda Alfredo 
Published: December 2020

Abstract
Breast cancer is a relevant public health problem that affects millions of women worldwide. Breast tumors are recognized as a clinically and molecular heterogeneous pathology, but the genomic basis of its variability remains poorly understood, mainly regarding the comprehensive of ethnicity/racial disparities and their consequences in genomics studies. Moreover, most of the comprehensive molecular characterizations are predominantly centered on Caucasian population. Thus, we deeply characterized the molecular architecture of breast cancer in a set of Mexican patients through genomic and transcriptomic portraits. We explored the molecular features of breast cancers in Mexican-Hispanic (HM) women and compared them with public multi-ethnic datasets. HM patients presented an earlier onset of the disease, in particular in the aggressive Basal-like/triple negative and Luminal B subtypes. The significant E17K hotspot mutation in AKT1 gene occurred in 8% of the HM tumors, an enriched prevalence exclusively seen in this dataset. An integrative analysis also revealed an important role of the AKT1/PIK3CA axis as a potentially druggable target and indicate an aggressive biology. Computational analysis allowed us to identify age-related COSMIC (v2) signature 1 to be present in a much broader spectrum of HM women than in those from other ethnicities. On the basis of transcriptome immunogenomic analysis across human population we identified that luminal breast tumors with HM ancestry presented an enhanced immunogenic phenotype than their Asiatic and Caucasian counterparts. To the best of our knowledge, this dataset represents the largest breast cancer genomics characterization of breast tumors in Mexican women, and, provides novel insights into molecular phenotypes and mechanisms underlying carcinogenesis in a group of Mexican Hispanic women. In conclusion, this study provides a conceptual framework to better understand ethnic disparities of breast cancer.
Citation Format: Sandra Lorena Romero-Cordoba, Ivan Salido-Guadarrama, Rosa Rebollar-Vega, Alberto Tenorio-Flores, Verónica Bautista-Piña, Felipe Villegas-Carlos, Carlos Dominguez-Reyes, Alfredo Hidalgo-Miranda. Comprehensive "omic" portraits of breast cancer in Mexican-Hispanic women [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-220.