bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite Darcy–Prandtl Number and Maximum Density Effects on Gill's Stability Problem
Authors: Naveen S. B. , Shankar B. M. , Shivakumara I. S. 
Published: June 2020

Abstract
The simultaneous effect of a time-dependent velocity term in the momentum equation and a maximum density property on the stability of natural convection in a vertical layer of Darcy porous medium is investigated. The density is assumed to vary quadratically with temperature and as a result, the basic velocity distribution becomes asymmetric. The problem has been analyzed separately with (case 1) and without (case 2) time-dependent velocity term. It is established that Gill's proof of linear stability effective for case 2 but found to be ineffective for case 1. Due to the lack of Gill's proof for case1, the stability eigenvalue problem is solved numerically and observed that the instability sets in always via traveling-wave mode when the Darcy–Prandtl number is not larger than 7.08. The neutral stability curves and isolines are presented for different governing parameters. The critical values of Darcy–Rayleigh number corresponding to quadratic density variation with respect to temperature, critical wave number, and the critical wave speed are computed for different values of governing parameters. It is found that the system becomes more stable with increasing Darcy–Rayleigh number corresponding to linear density variation with respect to temperature and the Darcy–Prandtl number.
Videoconference-Delivered Group-Based Physical Activity Self-Regulatory Support for Adults With Spinal Cord Injury: A Feasibility Study
Authors: Jeske Samantha J.D. , Brawley Lawrence R. , Arbour-Nicitopoulos Kelly P. 
Published: June 2020

Videoconferencing is a novel method for overcoming time and transportation barriers to leisure-time physical activity (LTPA) interventions. This study examined the feasibility of a group videoconference intervention on LTPA self-regulatory skills training in a sample of nine adults with spinal cord injury (SCI). Session implementation checklists and self-report surveys were administered during four weekly sessions to assess intervention management, group processes, intervention resources, and initial efficacy. Attendance rate was high (91.7%), and the average weekly session duration was 79.6 min. Participants reported high ratings of group cohesion, facilitator collaboration, session content comprehension, and ease in operating the videoconference platform. Knowledge sharing among the group ranged from 18 to 58 exchanges per session, demonstrating learning and group cohesion. LTPA frequency increased among 44% of participants, and 22% of participants achieved the SCI-specific aerobic guidelines. Overall, group videoconferencing holds promise for LTPA support among adults with SCI. Long-term research is warranted to test LTPA self-regulatory and behavioral effects.
Development and pilot testing of quality improvement indicators for integrated primary dementia care
Authors: Oostra Dorien L , Nieuwboer Minke S , Olde Rikkert Marcel G M , Perry Marieke 
Published: June 2020

BackgroundImplementation of integrated primary care is considered an important strategy to overcome fragmentation and improve quality of dementia care. However, current quality indicator (QI) sets, to assess and improve quality of care, do not address the interprofessional context. The aim of this research was to construct a feasible and content-wise valid minimum dataset (MDS) to measure the quality of integrated primary dementia care.MethodsA modified Delphi method in four rounds was performed. Stakeholders (n=15) (1) developed a preliminary QI set and (2) assessed relevance and feasibility of QIs via a survey (n=84); thereafter, (3) results were discussed for content validity during a stakeholder and (4) expert consensus meeting (n=8 and n=7, respectively). The stakeholders were professionals, informal caregivers, and care organisation managers or policy officers; the experts were professionals and researchers. The final set was pilot-tested for feasibility by multidisciplinary dementia care networks.ResultsThe preliminary set consisted of 40 QIs. In the survey, mean scores for relevance ranged from 5.8 (SD=2.7) to 8.5 (SD=0.7) on a 9-point Likert scale, and 25% of all QIs were considered feasible to collect. Consensus panels reduced the set to 15 QIs to be used for pilot testing: 5 quality of care, 3 well-being, 4 network-based care, and 3 cost-efficiency QIs. During pilot testing, all QIs were fully completed, except for well-being QIs.ConclusionA valid and feasible MDS of QIs for primary dementia care was developed, containing innovative QIs on well-being, network-based care and cost-efficiency, in addition to quality of care QIs. Application of the MDS may contribute to development and implementation of integrated care service delivery for primary dementia care.
Phase IA/IB study of single-agent tislelizumab, an investigational anti-PD-1 antibody, in solid tumors
Authors: Desai Jayesh , Deva Sanjeev , Lee Jong Seok , Lin Chia-Chi , Yen Chia-Jui , Chao Yee , Keam Bhumsuk , Jameson Michael , Hou Ming-Mo , Kang Yoon-Koo , Markman Ben , Lu Chang-Hsien , Rau Kun-Ming , Lee Kyung-Hun , Horvath Lisa , Friedlander Michael , Hill Andrew , Sandhu Shahneen , Barlow Paula , Wu Chi-Yuan , Zhang Yun , Liang Liang , Wu John , Paton Virginia , Millward Michael 
Published: June 2020

BackgroundThe programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) axis plays a central role in suppressing antitumor immunity; axis dysregulation can be used by cancer cells to evade the immune system. Tislelizumab, an investigational monoclonal antibody with high affinity and binding specificity for PD-1, was engineered to minimize binding to FcγR on macrophages to limit antibody-dependent phagocytosis, a potential mechanism of resistance to anti-PD-1 therapy. The aim of this phase IA/IB study was to investigate the safety/tolerability, antitumor effects and optimal dose and schedule of tislelizumab in patients with advanced solid tumors.MethodsPatients (aged ≥18 years) enrolled in phase IA received intravenous tislelizumab 0.5, 2, 5 or 10 mg/kg every 2 weeks; 2 or 5 mg/kg administered every 2 weeks or every 3 weeks; or 200 mg every 3 weeks; patients in phase IB received 5 mg/kg every 3 weeks. Primary objectives were to assess tislelizumab’s safety/tolerability profile by adverse event (AE) monitoring and antitumor activity using RECIST V.1.1. PD-L1 expression was assessed retrospectively with the VENTANA PD-L1 (SP263) Assay.ResultsBetween May 2015 and October 2017, 451 patients (n=116, IA; n=335, IB) were enrolled. Fatigue (28%), nausea (25%) and decreased appetite (20%) were the most commonly reported AEs. Most AEs were grade 1–2 severity; anemia (4.9%) was the most common grade 3–4 AE. Treatment-related AEs led to discontinuation in 5.3% of patients. Grade 5 AEs were reported in 14 patients; 2 were considered related to tislelizumab. Pneumonitis (2%) and colitis (1%) were the most common serious tislelizumab-related AEs. As of May 2019, 18% of patients achieved a confirmed objective response in phase IA and 12% in phase IB; median follow-up duration was 13.6 and 7.6 months, respectively. Pharmacokinetics, safety and antitumor activity obtained from both phase IA and IB determined the tislelizumab recommended dose; ultimately, tislelizumab 200 mg intravenous every 3 weeks was the dose and schedule recommended to be taken into subsequent clinical trials.ConclusionsTislelizumab monotherapy demonstrated an acceptable safety/tolerability profile. Durable responses were observed in heavily pretreated patients with advanced solid tumors, supporting the evaluation of tislelizumab 200 mg every 3 weeks, as monotherapy and in combination therapy, for the treatment of solid tumors and hematological malignancies.Trial registration numberNCT02407990.
Charged perfect fluid stellar structures with Bardeen model
Authors: Shamir M. Farasat , Mustafa G. , Hanif Quresha 
Published: June 2020

This paper is devoted to study static spherically symmetric model in the presence of charged perfect fluid. This is the generalization of neutral perfect fluid (when there is no charge) through the solution of Einstein Maxwell equations. For this purpose, we consider a suitable form of gravitational potential [Formula: see text] and the electric field [Formula: see text], already used in the literature. The value of mass-radius ratio or compactness [Formula: see text], which depends upon the chosen model exceeds the value [Formula: see text] corresponding to neutral stars. The most important feature of the current study is to use the Bardeen model geometry instead of usual Reissner–Nordström model for the matching conditions. In this case the energy density and pressure remain positive, bounded and monotonically decreasing whereas electric field is monotonically increasing. Also the causality condition, i.e. the magnitude of speed of sound must be less than the speed of light, is satisfied. Moreover, the behavior of all the physical parameters at the center and on surface of star of mass [Formula: see text] and for Her X-1 are tabulated. All the results by graphical analysis and tabular information suggest that Bardeen model provides physically realistic stellar structures.
Numerical analysis of Bragg grating-based slot-micro-ring coupling resonator system for electromagnetically-induced transparency-like effect
Authors: Zhao C. Y. , Chen P. Y. , Zhang C. M. 
Published: June 2020

We propose a novel bio-sensor structure composed of double sided-wall Bragg gratings and dual-slot-micro-ring waveguides. The slot waveguide is a better choice to interact the bio-material under investigation with the propagating light with in the slot region. The incident light field propagates clockwise through the slot micro-ring resonator, the reflection light field propagates counterclockwise in the slot Bragg grating. By optimizing the geometric parameters of the device, the spectral response is tailored to obtain a sharp resonant peak simulated by the finite- difference time-domain (FDTD) method. The spectrum can be tuned not only by geometrically changing the couple distance in slot Bragg grating resonator, but also by dynamically altering the depth and number of the Bragg grating. Furthermore, the device is easy to yield an extinction ratio of 11 dB, a FWHM of 1.1 nm and a quality factor of [Formula: see text]. The device with a small footprint can enable integration with some photonic devices on a chip and have great promising for applications including tunable sensors, slow-light devices and optical communication.
Fine-Grained Air Pollution Inference with Mobile Sensing Systems
Authors: Ma Rui , Liu Ning , Xu Xiangxiang , Wang Yue , Noh Hae Young , Zhang Pei , Zhang Lin 
Published: June 2020

Air pollution is a global health threat. Except static official air quality stations, mobile sensing systems are deployed for urban air pollution monitoring to achieve larger sensing coverage and greater sampling granularity. However, the data sparsity and irregularity also bring great challenges for pollution map recovery. To address these problems, we propose a deep autoencoder framework based inference algorithm. Under the framework, a partially observed pollution map formed by the irregular samples are input into the model, then an encoder and a decoder work together to recover the entire pollution map. Inside the decoder, we adopt a convolutional long short-term memory (ConvLSTM) model by revealing its physical interpretation with an atmospheric dispersion model, and further present a weather-related ConvLSTM to enable quasi real-time applications.
To evaluate our algorithm, a half-year data collection was deployed with a real-world system on a coastal area including the Sino-Singapore Tianjin Eco-city in north China. With the resolution of 500 m x 500 m x 1 h, our offline method is proved to have high robustness against low sampling coverage and accidental sensor errors, obtaining 14.9% performance improvement over existing methods. Our quasi real-time model better captures the spatiotemporal dependencies in the pollution map with unevenly distributed samples than other real-time approaches, obtaining 4.2% error reduction.
Longer-term recurrence rate after low versus high dose radioiodine ablation for differentiated thyroid Cancer in low and intermediate risk patients: a meta-analysis
Authors: Vardarli I. , Weidemann F. , Aboukoura M. , Herrmann K. , Binse I. , Görges R. 
Published: June 2020

Abstract
Background
Regarding the longer-term recurrence rate the optimal activity for the remnant thyroid ablation in patients with differentiated thyroid cancer (DTC) is discussed controversially. For the short-term ablation success rate up to 12 months there are already several meta-analyses. In this study we performed the first meta-analysis regarding the longer-term recurrence rate after radioactive 131-I administration.

Methods
We conducted an electronic search using PubMed/MEDLINE, EMBASE and the Cochrane Library. All randomized controlled trials (RCTs) assessed the recurrence rate after radioactive iodine ablation in patients with DTC, with a follow-up of at least two years were selected. Statistics were performed by using Review Manager version 5.3 and Stata software.

Results
Four RCTs were included in the study, involving 1501 patients. There was no indication for heterogeneity (I2 = 0%) and publication bias. The recurrence rate among patients who had a low dose 131-iodine ablation was not higher than for a high dose activity (odds ratio (OR) 0.93 [95% confidence interval (CI) 0.53–1.63]; P = 0.79). The mean follow-up time was between 4.25 and 10 years. The subgroup analysis regarding the TSH stimulated thyroglobulin values (< 10 ng/mL versus < 2 ng/mL versus ≤1 ng/mL) showed no influence on recurrence rate.

Conclusions
For the first time we showed that the longer-term, at least 2-year follow-up, recurrence rate among patients who had 131-iodine ablation with 1.1 GBq was not higher than with 3.7 GBq.
Injury related adult deaths in Addis Ababa, Ethiopia: analysis of data from verbal autopsy
Authors: Anteneh Aderaw , Endris Bilal Shikur 
Published: June 2020

Abstract
Background
Injury related deaths are causing huge impact on families and communities throughout the world. Reports show that developing countries are highly affected by injury deaths. Ethiopia is among the countries that are highly affected by injury deaths especially road traffic accident. Previous studies in Ethiopia concerning injury deaths were mostly based on hospital records. However, in the context of Ethiopia, where majority of the deaths are happening outside health facilities, hospital-based studies cannot give the exact proportion of injury deaths. This study aimed to assess the proportion and types of injury deaths in Addis Ababa and the distribution with different socio-demographic characteristics using data from verbal autopsy.

Methods
We used verbal autopsy data of Addis Ababa Mortality Surveillance Program. The basic source of data for Addis Ababa Mortality Surveillance is burial surveillance from all cemeteries of Addis Ababa. We analyzed causes of injury mortality by different characteristics and tried to show the trends.

Results
Over the 8 years period of time injury has contributed about 7 % of the total deaths. Majority of injury related deaths were among males. Traffic accidents were the major injury related deaths for both sexes; intentional self-harm was highly observed among males compared with females. The findings of this study showed that the proportion of injury related deaths decreased with increasing age.

Conclusions
This study witnessed that deaths resulting from injuries are substantial health challenges in Addis Ababa. Road traffic accident is the most common cause of injury related deaths in the study area. The findings also indicated that males and the productive age groups are highly affected by injury deaths.
Two lucky survivors of thoracic impalement in childhood: case report and literature review
Authors: Negash Samuel , Mammo Tihitena Negussie 
Published: June 2020

Abstract
Background
Penetrating thoracic injuries are uncommon in childhood. Massive penetrating injury due to impalement is even more rare and has scarcely been reported. It has a dramatic clinical presentation and is often fatal, depending on the organs injured.

Case presentation
Two boys presented with an unusual mechanism of injury. They fell from a height to be impaled by a large stick. Appropriate emergency medical service was not available and surgery was delayed by more than 24 h after the accident. Both children were labelled “lucky” as they survived the injury without any significant sequelae.

Conclusion
We discuss two new cases of pediatric thoracic impalement and perform the first literature review on the subject. Emphasis should be given to the initial care which comprises avoiding premature removal, rapid transport, resuscitation, anti-tetanus and antibiotics. All reported cases had a favorable outcome, even those managed within the constraints of low-income countries.
Age-associated genes in human mammary gland drive human breast cancer progression
Authors: Gu Xiang , Wang Bingzhi , Zhu Haiyan , Zhou You , Horning Aaron M. , Huang Tim H-M , Chen Yidong , Houghton Peter , Lai Zhao , Michalek Joel E. , Sun Lu-Zhe 
Published: June 2020

Abstract
Background
Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains poorly understood.

Method
We analyzed transcriptomics of the matched normal breast tissues from the 82 breast cancer patients in The Cancer Genome Atlas (TCGA) dataset with linear regression for genes with age-associated expression that are not associated with menopause. We also analyzed differentially expressed genes between the paired tumor and non-tumor breast tissues in TCGA for the identification of age and breast cancer (ABC)-associated genes. A few of these genes were selected for further investigation of their malignancy-regulating activities with in vitro and in vivo assays.

Results
We identified 148 upregulated and 189 downregulated genes during aging. Overlapping of tumor-associated genes between normal and tumor tissues with age-dependent genes resulted in 14 upregulated and 24 downregulated genes that were both age and breast cancer associated. These genes are predictive in relapse-free survival, indicative of their potential tumor promoting or suppressive functions, respectively. Knockdown of two upregulated genes (DYNLT3 and P4HA3) or overexpression of the downregulated ALX4 significantly reduced breast cancer cell proliferation, migration, and clonogenicity. Moreover, knockdown of P4HA3 reduced growth and metastasis whereas overexpression of ALX4 inhibited the growth of xenografted breast cancer cells in mice.

Conclusion
Our study suggests that transcriptome alterations during aging may contribute to breast tumorigenesis. DYNLT3, P4HA3, and ALX4 play significant roles in breast cancer progression.
First report of Wolbachia in Damaeus onustus (Acari: Oribatida)
Authors: Konecka Edyta , Olszanowski Ziemowit , Jagiełło Aleksandra 
Published: June 2020

Abstract
Purpose
Little is known about the distribution and phylogeny of bacterial endosymbionts in oribatid mites (Acari: Oribatida). Thus, we undertook the issue of occurrence of these microbial symbionts in this arthropod group.

Methods
We used PCR technique for detection of Wolbachia in Damaeus onustus. Phylogenetic analysis of the bacterium was conducted based on the 16S rDNA sequence.

Results
To the best of our knowledge, we present a novel finding of Wolbachia infection in the sexually reproducing oribatid mite, D. onustus. The presence of uninfected individuals (ca. 93%) suggests that the bacteria do not function as primary symbionts. A comparison of the bacterial 710-bp 16S rDNA sequence detected in the oribatid mite with the sequences deposited in GenBank revealed its 92–93% similarity to the 16S rDNA sequences of Wolbachia identified in some springtails (Collembola) and Bryobia sp. mite. Bacteria from D. onustus showed phylogenetic relationships with Wolbachia from springtails, Megalothorax minimus and Neelus murinus, which were included by other authors into a separate Wolbachia clade.

Conclusion
Our finding suggests that the strains of Wolbachia from D. onustus may form a new Wolbachia supergroup.
Both short and long distance migrants use energy-minimizing migration strategies in North American herring gulls
Authors: Anderson Christine M. , Gilchrist H. Grant , Ronconi Robert A. , Shlepr Katherine R. , Clark Daniel E. , Fifield David A. , Robertson Gregory J. , Mallory Mark L. 
Published: June 2020

Abstract
Background
Recent studies have proposed that birds migrating short distances migrate at an overall slower pace, minimizing energy expenditure, while birds migrating long distances minimize time spent on migration to cope with seasonal changes in environmental conditions.

Methods
We evaluated variability in the migration strategies of Herring Gulls (Larus argentatus), a generalist species with flexible foraging and flight behaviour. We tracked one population of long distance migrants and three populations of short distance migrants, and compared the directness of their migration routes, their overall migration speed, their travel speed, and their use of stopovers.

Results
Our research revealed that Herring Gulls breeding in the eastern Arctic migrate long distances to spend the winter in the Gulf of Mexico, traveling more than four times farther than gulls from Atlantic Canada during autumn migration. While all populations used indirect routes, the long distance migrants were the least direct. We found that regardless of the distance the population traveled, Herring Gulls migrated at a slower overall migration speed than predicted by Optimal Migration Theory, but the long distance migrants had higher speeds on travel days. While long distance migrants used more stopover days overall, relative to the distance travelled all four populations used a similar number of stopover days.

Conclusions
When taken in context with other studies, we expect that the migration strategies of flexible generalist species like Herring Gulls may be more influenced by habitat and food resources than migration distance.
The potential of coupled carbon storage and geothermal extraction in a CO2-enhanced geothermal system: a review
Authors: Wu Yu , Li Pan 
Published: June 2020

AbstractThe increasing demand for energy makes it difficult to replace fossil fuels with low-carbon energy sources in the short term, and the large amount of CO2 emitted by fossil fuel combustion increases global warming. Carbon capture and storage (CCS) technologies for reducing CO2 emissions in power plants and industrial processes have been developed. High costs and security issues limit industrial applications of these technologies, so an alternative for carbon reduction is needed, i.e., CO2 as a working fluid for coupled carbon storage and geothermal extraction in an Enhanced Geothermal System (EGS). We describe the status of global carbon emissions, CCS technologies, and their challenges. The characteristics of CO2 as a working fluid are compared from thermophysical and thermodynamic perspectives, and the solubility of CO2 in reservoir fluids with different ionic strengths, pressures, and temperatures is analyzed. The influence of artificial stimulation on the permeability of an EGS reservoir is described. Through heat extraction experiment of water alternating supercritical CO2 (SCCO2) cycle injection, the effects of CO2–fluid–rock interactions on the reservoir’s structure and of mineral dissolution and precipitation on geological CO2 storage are analyzed. We summarize the application prospects for this alternative and the challenges of future application.