bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-measure approach for assessing the performance of fMRI preprocessing strategies in resting-state functional connectivity
Authors: Kassinopoulos Michalis , Mitsis Georgios D. 
Published: November 2019

AbstractIt is well established that head motion and physiological processes (e.g. cardiac and breathing activity) should be taken into consideration when analyzing and interpreting results in fMRI studies. However, even though recent studies aimed to evaluate the performance of different preprocessing pipelines there is still no consensus on the optimal strategy. This is partly due to the fact that the quality control (QC) metrics used to evaluate differences in performance across pipelines have often yielded contradictory results. Furthermore, preprocessing techniques based on physiological recordings or data decomposition techniques (e.g. aCompCor) have not been comprehensively examined. Here, to address the aforementioned issues, we propose a framework that summarizes the scores from eight previously proposed and novel QC metrics to a reduced set of two QC metrics that reflect the signal-to-noise ratio and the reduction in motion artifacts and biases in the preprocessed fMRI data. Using this framework, we evaluate the performance of three commonly used practices on the quality of data: 1) Removal of nuisance regressors from fMRI data, 2) discarding motion-contaminated volumes (i.e., scrubbing) before regression, and 3) low-pass filtering the data and the nuisance regressors before their removal. Using resting-state fMRI data from the Human Connectome Project, we show that the scores of the examined QC metrics improve the most when the global signal (GS) and about 17% of principal components from white matter (WM) are removed from the data. Finally, we observe a small further improvement with low-pass filtering at 0.20 Hz and milder variants of WM denoising, but not with scrubbing.
Reduced Auditory Steady State Responses in Autism Spectrum Disorder
Authors: Seymour R.A , Rippon G , Gooding-Williams G , Sowman P.F. , Kessler K 
Published: November 2019

AbstractBackgroundAuditory steady state responses (ASSRs) are elicited by clicktrains or amplitude-modulated tones, which entrain auditory cortex at their specific modulation rate. Previous research has reported reductions in ASSRs at 40Hz for autism spectrum disorder (ASD) participants and first-degree relatives of people diagnosed with ASD [1,2].MethodsUsing a 1.5s-long auditory clicktrain stimulus, designed to elicit an ASSR at 40Hz, this study attempted to replicate and extend these findings. Magnetencephalography (MEG) data were collected from 18 adolescent ASD participants and 18 typically developing controls.ResultsThe ASSR localised to bilateral primary auditory regions. Regions of interest were thus defined in left and right primary auditory cortex (A1). While the transient gamma-band response (tGBR) from 0-0.1s following presentation of the clicktrain stimulus was not different between groups, for either left or right A1, the ASD group had reduced oscillatory power at 40Hz from 0.5 to 1.5s post-stimulus onset, for both left and right A1. Additionally, the ASD group had reduced inter-trial coherence (phase consistency over trials) at 40Hz from 0.64-0.82s for right A1 and 1.04-1.22s for left A1.LimitationsIn this study, we did not conduct a clinical autism assessment (e.g. the ADOS), and therefore it remains unclear whether ASSR power and/or ITC are associated with the clinical symptoms of ASD.ConclusionOverall, our results support a specific reduction in ASSR oscillatory power and inter-trial coherence in ASD, rather than a generalised deficit in gamma-band responses. We argue that this could reflect a developmentally relevant reduction in non-linear neural processing.
More evidence for a long-latency mismatch response in urethane-anaesthetised mice
Authors: O’Reilly Jamie A. , Angsuwatanakul Thanate 
Published: November 2019

AbstractProlonged electrophysiological responses to oddball stimuli have recently been observed from anaesthetised rodents. This deviant-related activity is found to extend through 200 to 700 ms post-stimulus; a window typically obstructed from analysis by the response to subsequent stimuli in the auditory sequence. A simple methodological development in terms of difference waveform computation using two adjoining evoked responses has enabled visualisation of this activity over a longer window of analysis than previously available. In the present study, the double-epoch subtraction technique was retroactively applied to data from 13 urethane-anaesthetised mice. Oddball paradigm waveforms were compared with those of a many-standards control sequence, confirming that oddball stimuli evoked long-latency potentials that did not arise from standard or control stimuli. Statistical tests were performed at every time point from 0 to 700 ms post stimuli to highlight regions of significant difference. Oddball-induced mismatch responses were found to display significantly greater long-latency potentials than identical stimuli presented in an equal-probability context. As such, it may be concluded that long-latency potentials were evoked by the oddball condition. How this feature of the anaesthetised rodent mismatch response relates to human mismatch negativity is unclear, although it may be tentatively linked to the human P3a component, which is considered to emerge downstream from mismatch negativity.
Personalized single-cell networks: a framework to predict the response of any gene to any drug for any patient
Authors: Harikumar Haripriya , Quinn Thomas P. , Rana Santu , Gupta Sunil , Venkatesh Svetha 
Published: November 2019

AbstractBackgroundThe last decade has seen a major increase in the availability of genomic data. This includes expert-curated databases that describe the biological activity of genes, as well as high-throughput assays that measure gene expression in bulk tissue and single cells. Integrating these heterogeneous data sources can generate new hypotheses about biological systems. Our primary objective is to combine population-level drug-response data with patient-level single-cell expression data to predict how any gene will respond to any drug for any patient.MethodsWe take 2 approaches to benchmarking a “dual-channel” random walk with restart (RWR) for data integration. First, we evaluate how well RWR can predict known gene functions from single-cell gene co-expression networks. Second, we evaluate how well RWR can predict known drug responses from individual cell networks. We then present two exploratory applications. In the first application, we combine the Gene Ontology database with glioblastoma single cells from 5 individual patients to identify genes whose functions differ between cancers. In the second application, we combine the LINCS drug-response database with the same glioblastoma data to identify genes that may exhibit patient-specific drug responses.ConclusionsOur manuscript introduces two innovations to the integration of heterogeneous biological data. First, we use a “dual-channel” method to predict up-regulation and down-regulation separately. Second, we use individualized single-cell gene co-expression networks to make personalized predictions. These innovations let us predict gene function and drug response for individual patients. Taken together, our work shows promise that single-cell co-expression data could be combined in heterogeneous information networks to facilitate precision medicine.
Angiocrine factors from HUVECs amplify erythroid cells
Authors: Sugimura Ryohichi , Ohta Ryo , Mori Chihiro , Sano Emi , Sugiyama Tatsuki , Nagasawa Takashi , Niwa Akira , Torisawa Yu-suke , Saito Megumu K. 
Published: November 2019

AbstractErythropoiesis is regulated by microenvironmental factors from the vasculature. Enhanced erythropoiesis, which occurs under stress or during development, amplifies erythroid cells to meet the demand of red blood cells. This process uncouples cell division and differentiation, thus the accumulated erythroid cells remain undifferentiated in the vasculature. However, little is known about how vascular endothelial cells (ECs) regulate erythropoiesis. Here we identified that human umbilical vein endothelial cells (HUVECs) keep erythroid cells undifferentiated and amplify their number. We determined that HUVECs amplify erythroid cells via secreted angiocrine factors. The expression profile of these factors suggested that they resemble macrophage-crines for enhanced erythropoiesis. Molecularly, HUVECs mediate the activation of ERK signaling. These data indicate that angiocrine factors from HUVECs enhance erythropoiesis via the amplification of undifferentiated erythroid cells. Our study contributes to the ultimate goal of harnessing erythropoiesis to replace blood transfusions.
Schizophrenia patients show aberrant brain dynamics associated with gestalt-perception and corollary discharge: Reflections from ERP and fMRI findings
Authors: Sasidharan Arun , Nair Ajay Kumar , Marigowda Vrinda , Lukose Ammu , John John P , Kutty Bindu M 
Published: November 2019

AbstractBackgroundSchizophrenia is a disorder of higher mental attributes, and is characterized by psychotic symptoms that are believed to involve a basic inability to make valid predictions about expected sensations and experiences. These have been reported separately while monitoring either externally generated environmental patterns (e.g. gestalt-perception) or self-generated sensory experiences (e.g. corollary-discharge). As the pathophysiology behind predictive dysfunction is better viewed as an aberration in brain’s functional synchrony, a whole brain assessment using electroencephalographic (EEG) event related potential (ERP) and functional magnetic resonance imaging (fMRI) techniques, would offer a wider perspective to brain network abnormalities in schizophrenia.MethodWe used our lab-developed game-based task which presents degraded two-tone images to assess gestalt-perception, and simultaneously alters the congruency between participant’s button-press response and its auditory feedback to assess corollary-discharge. In both patients with schizophrenia and age-matched healthy controls, we explored event-related changes in an EEG-ERP study (n=21 each) and whole brain functional connectivity changes in a fMRI study (patients,n=12; controls,n=16), using the same task.ResultsPatients showed reduced event-related EEG dynamics during both the error-prediction conditions (gestalt-perception and corollary-discharge), which include reduction in average waveforms (around N170 and N1-P2 complex, respectively) and altered theta dynamics (power and phase). Source-level EEG measures were clustered around the cingulo-insular network. fMRI functional connectivity analysis also found the abnormality in these brain regions, forming significantly weak connections with right insular/opercular cortex.ConclusionsThis is the first study to explore ‘thalamo-cortical dysfunction hypothesis’ in schizophrenia by integrating prediction-error-coding during perception (‘gestalt-perception’) and action (‘corollary-discharge’) using two neuroimaging modalities (EEG-ERP and fMRI). Besides adding to the knowledgebase of schizophrenia research, our novel task design and findings on theta-oscillation could benefit in the development of effective neuromodulatory therapeutic tools for patients with schizophrenia such as neurofeedback and transcranial brain stimulation.
Profitability calculations under trial of strength
Authors: Laguecir Aziza , Chapman Christopher S. , Kern Anja 
Published: November 2019

Purpose
The purpose of this paper is to examine the organizational construction of profit at the responsibility-centre level, how underlying cost calculations are challenged, and the role of accountants therein.

Design/methodology/approach
This paper analyses profit calculation in a public social housing organization that experienced New Public Management (NPM). Participant observations, archives and interviews inform the study over three years, enabling access to day-to-day practices.

Findings
This study examines a trial of strength that revisited long-existing profitability and cost calculations. Accountants held competing views of how to treat labour costs. Some were anti-programme during a trial of incompatibility, while others were programme defenders. The authors also provide evidence of the stability of an established network and its resistance to the claims of an adversary spokesperson in a trial of strength. The concept of trial of incompatibility proved helpful in showing how the actor networks within OMEGA played out the tension between profit orientation and the social mission of offering affordable dwellings.

Research limitations/implications
The paper provides rare qualitative data on the significant and complex role of calculative costing choices in determining intra-organizational profitability and its interference with the inherent social mission of the organization.

Practical implications
The authors suggest that profitability calculations are influenced not only by economic context but also by different views of organizational actors regarding how to calculate profit. These calculations would benefit from a more detailed and explicit documentation of reasons for choices made, given the potential for different and, in principle, equally valid approaches. The authors provide further evidence of the complexity of the public social housing sector.

Social implications
This research points to a departure from the mission of public social housing in the face of NPM reforms and further questions the compatibility of a profit orientation with the provision of affordable dwellings.

Originality/value
The findings show intra-accounting variation regarding a specific element of profit calculation (labour costs) relating to the organization’s wider mission and status.
A study of motivation and team member selection in online games
Authors: Lou Tianyang , Zu Yuning , Zhu Ling 
Published: November 2019

Purpose
The purpose of this paper is to investigate impact of playing motivation on team member selection (TMS) in online games specifically related to Massively Multiplayer Online Role-playing Game environment.

Design/methodology/approach
A self-administered questionnaire was developed and administered to an online sample of 9,335 CR3 players.

Findings
The findings of this research indicated that social and immersion motivations have a significant effect on TMS. Additionally, it was discovered that achievement motivation has a positive relationship with dispositional TMS, a negative relationship to bond-based TMS. The moderation effect of frequency and gender is also demonstrated.

Research limitations/implications
The study verified the relationships of the theoretical model of the game motivation and TMS.

Originality/value
This study provides advice to operators of online games when motivating players to work in groups.
WOVOdat – the global volcano unrest database aimed at improving eruption forecasts
Authors: Costa Fidel , Widiwijayanti Christina , Nang Thin Zar Win , Fajiculay Erickson , Espinosa-Ortega Tania , Newhall Christopher 
Published: November 2019

PurposeThe purpose of this paper is to highlight the importance of a comprehensive global database on volcanic unrest (WOVOdat) as a resource to improve eruption forecasts, hazard evaluation and mitigation actions.Design/methodology/approachWOVOdat is a centralized database that hosts multi-parameter monitoring data sets from unrest and eruption episodes of volcanoes worldwide. Its online interface (https://wovodat.org/) allows interactive data analysis and comparison between volcanoes and eruption styles, which is needed during volcanic crises, as well as to perform basic research on pre-eruption processes, teaching and outreach.FindingsWOVOdat aims to standardize and organize the myriad of monitoring data types at the global scale. Users can compare changes during a crisis to past unrest episodes, and estimate probabilities of outcomes using evidence-based statistics. WOVOdat will be to volcanology as an epidemiological database is to medicine.Research limitations/implicationsThe success of eruption forecast relies on data completeness, and thus requires the willingness of observatories, governments and researchers to share data across the volcano community.Practical implicationsWOVOdat is a unique resource that can be studied to understand the causes of volcanic unrest and to improve eruption forecasting.Originality/valueWOVOdat is the only compilation of standardized and multi-parameter volcano unrest data from around the world, and it is freely and easily accessible through an online interface.
Strategy execution in public sectors: empirical evidence from Belgium
Authors: Bhimavarapu Sasidhar Reddy , Kim Seong-Young , Xiong Jie 
Published: November 2019

Purpose
Many public sector organizations have shown a consistent lack of capability to execute their strategic plans compared with private sector organizations. This failure explains why most public sector organizations are grappling with the dynamics of the twenty-first century in service delivery. Further, the strategy execution gap is vast in the public sector organizations than in the private sector organizations. The purpose of this paper is built based on the curiosity to develop a conceptual model that can close the strategy execution gap in public sector organizations.

Design/methodology/approach
The research adopted a qualitative research design, particularly, a case study research design approach as an ideal tool to conduct a holistic and in-depth survey of the trends in strategy execution in the public sector.

Findings
From the findings of the study, it has been found that five out of the nine strategy execution components that were investigated showed higher scores. These strategy execution components perceived to be vital by this study and were integrated into the MERIL-DE model, which will significantly contribute to closing the strategy execution gap in the public sector.

Originality/value
This research was built based on the curiosity to develop a conceptual model, the MERIL-DE model that can close the strategy execution gap in public sector organizations.
Surviving disruption: the grocer's tale
Authors: Blitz Amy 
Published: November 2019

Purpose
The US economy has undergone major macro disruption since the mid-1990s. Focusing on the retail grocery sector, this paper aims to compare the divergent strategies and outcomes of three key players to identify strategies that work vs those that do not during turbulent times, relevant to other sectors as well.

Design/methodology/approach
Using the S&P 500 from 1996 to 2019 as a case selection method, the paper compares A&P, which died in 2015, one of just 12 of the original 500 companies to do so during the period; Kroger, which has held strong and has stayed on the S&P 500 list throughout the period; and Whole Foods, the only grocer to rise onto the list during the period, dropped in 2017 when it was bought by Amazon.

Findings
A key differentiator separating A&P from Kroger and Whole Foods is relentless pursuit of customer satisfaction. This may seem axiomatic but is too often lost under investor pressures for short-term gains.

Practical implications
Successful companies view such pursuit as an ongoing process requiring continual evolution even reinvention as customers’ preferences and expectations change. Related to this is the need to maintain an ongoing focus on creating value for customers, as well as for the employees, suppliers and other key stakeholders who shape the customer experience. Finally, to maintain such a focus, companies must also commit to long-term investment not just short-term profits or gains for shareholders.

Originality/value
The use of the S&P data as a case selection method frames the cases in context of the broader US economy and provides a strong foundation for comparing companies with diverse strategies and outcomes while facing the same macro disruptions and uncertainties.
Dependence on tips and sexual harassment vulnerability of hotel employees in Accra, Ghana
Authors: Mensah Christopher 
Published: November 2019

PurposeThe purpose of this paper is to examine the relationship between perceived dependence on tips and vulnerability to sexual harassment (SH) among hotel employees in Accra Metropolis, Ghana.Design/methodology/approachWithin a cross-sectional research design, 583 employees from 55 hotels completed self-administered questionnaires. Descriptive statistics,χ2test of independence, Kruskal–Wallis test were used to analyse collected data.FindingsResults of the study reveal that dependence on tips is related to SH vulnerability of food and beverage staff. Furthermore, dependence on tips engenders a perception of SH climate. Compared to guests and co-workers, supervisors were least identified as perpetrators of SH in hotel workspaces. Guests were responsible for unwanted sexual attention, whereas co-workers pose the greatest risk for gender harassment.Practical implicationsHotel management should invest in the publication of educational materials such as leaflets and posters indicating unacceptability of inappropriate sexual behaviours.Originality/valueThis paper is one of the pioneers to have assessed the relationship between dependence on tips and perceived climate for SH as well as vulnerability to SH in a hotel context.
Effectuation logic in digital business model transformation
Authors: Baber William W. , Ojala Arto , Martinez Ricardo 
Published: November 2019

PurposeThe purpose of this paper is to study how digital business models evolve when entrepreneurs move to new digital platforms and how this evolution is related to effectuation and causation logics.Design/methodology/approachThis study applies a multiple case study approach to investigate how digital business models change in small, Japanese high-tech firms providing their innovations through different digital platforms. To investigate digital business models, this study considers the elements that comprise general business models. The case firms were selected based on size, products and transitions from physical to various digital platforms. Semi-structured interviews were conducted with the key decision-makers from the case firms.FindingsThe findings show that through digital transformation, the case firms’ digital business models evolved by following effectuation logic as well as causal logic. All the firms employed causal logic when moving to new platforms, among other actions. The case firms used effectual logic with success for product development and adjustments to their network. Especially firms providing video games relied on effectuation for high impact products. Effectual logic did not play a role at all in changes to value delivery and had only little impact on revenue structures.Originality/valueThis research helps understand how digitalization of platforms and subsequent moves to newer digital platforms improve a firm by changing the business model elements through effectuation and causation logics. This research extends the understanding of digital business model transformation to a more granular level, business model elements.