bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base
Authors: Liu Chrissy , Rein Lisa , Clarke Callisia , Mogal Harveshp , Tsai Susan , Christians Kathleen K. , Gamblin T. C. 
Published: May 2020

AbstractBackground and ObjectivesGallbladder carcinoma (GBC) has a poor prognosis. Studies demonstrated that teaching facilities may provide a lower risk of mortality in patients undergoing pancreatic and colon resection vs nonteaching facilities. We hypothesized that survival rates are higher in academic cancer centers (ACCs) vs community cancer centers (CCCs).MethodsPatients with all stages of GBC were identified from the National Cancer Database (2007‐2012). Propensity score matching adjusted for selection bias. Descriptive statistics were calculated for all variables. Overall survival (OS) was compared by facility type (ACC vs CCC) and case volume (low vs high) via multivariable Cox proportional hazards regression.ResultsA total of 7967 patients met the inclusion criteria. Following propensity matching, 2801 patients were analyzed from each facility type. Median OS following surgery was higher for ACC (20.99 months, 95% confidence interval [CI], 19.61‐22.64, P = .002) than CCC (17.68 months, 95% CI, 16.46‐19.25). Following Cox modeling, GBC treatment at ACCs was a protective factor for OS (adjusted hazard ratio 0.876, 95% CI, 0.801‐0.958, P = .004).DiscussionGBC treatment at ACCs is an independent predictor of OS. High volume ACCs are associated with improved OS compared with low volume ACCs. The site of care and case volume in ACCs may contribute to improved survival outcomes.
Outcomes of neoadjuvant chemotherapy before CRS‐HIPEC for patients with appendiceal cancer
Authors: Chen JC , Beal Eliza W. , Hays John , Pawlik Timothy M. , Abdel‐Misih Sherif , Cloyd Jordan M. 
Published: May 2020

AbstractBackgroundCytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is indicated for patients with peritoneal dissemination of appendiceal cancer. The role of neoadjuvant chemotherapy (NAC) before CRS‐HIPEC remains controversial.MethodsA retrospective review of adult patients who underwent CRS ± HIPEC for metastatic appendiceal cancer between 2000‐2017 was performed. Patients who received NAC followed by surgery were compared with those who underwent surgery first (SF) with and without 1:1 propensity score matching (PSM).ResultsAmong 803 patients with appendiceal cancer who underwent CRS ± HIPEC, 225 (28%) received NAC, and 578 (72%) underwent SF. After PSM (n = 186), median overall survival (OS) did not differ (NAC: 40 vs SF: 56 months; P = .210) but recurrence‐free survival (RFS) was worse among patients who received NAC (14 vs 22 months; P = .007). NAC was independently associated with worse OS (hazards ratio [HR], 1.81; 95% confidence interval [CI], 1.03‐3.18) and RFS (HR, 1.93; 95% CI, 1.25‐2.99).ConclusionIn this multi‐institutional retrospective analysis of patients with peritoneal dissemination from appendiceal cancer, the use of NAC before CRS‐HIPEC was associated with worse OS and RFS even after PSM and multivariable regression. Immediate surgery should be considered for patients with disease amenable to complete cytoreduction.
The Role of Gender in the Associations Among Posttraumatic Stress Symptoms, Anger, and Aggression in Russian Adolescents
Authors: Isaksson Johan , Sukhodolsky Denis G. , Koposov Roman , Stickley Andrew , Ruchkin Vladislav 
Published: May 2020

AbstractSymptoms of posttraumatic stress disorder (PTSD) have been linked to anger and aggressive behavior in adult and veteran populations. However, research on the associations among anger, aggression, and PTSD in adolescents is lacking, particularly regarding differences between the sexes. To address this research gap, we used self‐report data from Russian adolescents (N = 2,810; age range: 13–17 years) to perform a full path analysis examining the associations between PTSD symptoms and the emotional (anger traits) and cognitive (rumination) components of anger as well as physical/verbal and social aggression, after adjusting for depressive symptoms. We also examined the interaction effects between PTSD symptoms and sex on anger and aggression. The results indicated that girls scored higher on measures of anger and PTSD symptoms, ds = 0.20–0.32, whereas boys scored higher on measures of physical and verbal aggression, d = 0.54. Clinical levels of PTSD symptoms were associated with anger rumination, β = .16, and trait anger, β = .06, and an interaction effect for PTSD symptoms and sex was found for aggression, whereby boys with clinical levels of PTSD symptoms reported more physical/verbal and social aggression, βs = .05 and .20, respectively. Our findings suggest that PTSD symptoms may have an important impact on anger, anger rumination, and aggression during adolescence. In particular, boys seem to have an increased risk for aggressive behavior in the presence of PTSD symptoms. The present results highlight the importance of taking anger and aggression into account when evaluating PTSD.
Device‐Induced Neocollagenesis: Profibrotic Response or True Neocollagenesis?
Authors: Natari Sheila , Kim Ko Eun , Ryu Sook In , Park Ji Hyun , Kim Il‐Hwan 
Published: May 2020

Background and ObjectivesMany light and radiofrequency‐based rejuvenation devices have claimed to increase collagen production in the skin dermal tissue. However, there has not been enough scientific evidence to prove whether the result is just a profibrotic response or not. We aimed to find the optimal skin rejuvenation device that shows true neocollagenesis.Study Design/Materials and MethodsWe evaluated dermal collagen thickness and gene expression of procollagen type 1, 3, matrix metalloproteinase‐3 (MMP‐3), and transforming growth factor‐β (TGF‐β) resulting from different energy‐based devices in a rat model in vivo. The wound‐healing response was evaluated histologically and by real‐time polymerase chain reaction (RT‐PCR) at immediate, 1st, 2nd, 4th, 8th, and 12th week after the initial procedure.ResultsAt the 12th week, the most relevant changes of the dermal thickness were found in specimens after treatment with electrosurgical unit, fractional CO2 and 1064 nm Q‐switched Nd:YAG. Procollagen 1 and 3 were also found to be the highest in electrosurgical unit, fractional CO2, and microneedle radiofrequency. Dramatic changes of MMP‐3 and TGF‐β were remarkable at the early observation but went back to normal level at 12th week. The ratio of procollagen 1 and 3 was found to be the lowest with Q‐Switched Nd:YAG 1064 nm and fractional CO2.ConclusionElectrosurgical unit resulted in most significant changes, but due to irreversible thermal damage and extremely high procollagen results it is considered as a profibrotic response. Fractional CO2 and Q‐Switched Nd:YAG 1064 nm are applicable to face skin rejuvenation treatment considering thickening of dermal tissue and lower procollagen 1:3 ratio similar to the neocollagenesis purpose. Lasers Surg. Med. © 2020 Wiley Periodicals LLC
Clinical Study Demonstrates that Electromagnetic Muscle Stimulation Does Not Cause Injury to Fat Cells
Authors: Zachary Christopher B. , Burns A. Jay , Pham Linda D. , Jimenez Lozano Joel N. 
Published: May 2020

Background and ObjectivesA previous pre‐clinical study on electromagnetic muscle stimulation (EMMS) suggested that fat cell apoptosis occurs following treatment in a porcine model. While EMMS can induce changes in muscle, the effect on fat tissue is not established. This clinical study sought to assess adipose tissue response to EMMS in comparison to cryolipolysis treatment.Study Design/Materials and MethodsStudy subjects were recruited prior to abdominoplasty to receive body contouring treatments and subsequently to obtain tissue for histological analysis. Non‐invasive abdominal treatments were delivered using a commercially available (n = 6) or prototype (n = 3) EMMS system or a cryolipolysis system (n = 2). Subjects received a single EMMS treatment (100% intensity for 30 minutes) or a single cryolipolysis treatment (−11°C for 35 minutes) to the abdomen. Superficial and deep (i.e., adjacent to muscle layer) subcutaneous adipose tissue was harvested at set timepoints post‐treatment. The presence or absence of an inflammatory response was evaluated using standard hematoxylin and eosin (H&E) staining. As adipocytes that are destined to become apoptotic cannot be distinguished by traditional H&E staining during the early phases of injury, irreversible fat cell injury was assessed using perilipin immunofluorescence.ResultsFollowing H&E histological analysis at 3, 10, 11, and 17 days post‐treatment, no EMMS‐treated samples showed an inflammatory response in either the superficial or deep subcutaneous adipose tissue. For the cryolipolysis‐treated adipose tissue, however, the H&E staining revealed a marked inflammatory response with an influx of neutrophils, lymphocytes, and macrophages at timepoints consistent with previous histological studies. Further, loss of perilipin staining provided clear visual evidence of irreversible fat cell injury in the cryolipolysis‐treated adipose tissue. In contrast, the electromagnetic muscle stimulation‐treated samples showed persistence of perilipin staining of adipose tissue indicating that all fat cells were viable.ConclusionThis study failed to demonstrate either fat cell injury or inflammatory response following EMMS treatment. While electromagnetic muscle stimulation may non‐invasively induce muscle changes, this clinical study found no evidence of an impact injurious or otherwise on subcutaneous fat. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC
When the American dream fails: The effect of perceived economic inequality on present‐oriented behavior
Authors: Bak Hyuna , Yi Youjae 
Published: May 2020

AbstractEconomic inequality is worsening worldwide and is associated with various social problems. Although research on inequality has been conducted in various academic fields, research on how perceived inequality affects individual decision making is relatively limited in the marketing field. Recognizing this gap, this study examines how perceived economic inequality can affect individual behavior and decision making from the perspective of time frame. The results of four studies reveal that perceived economic inequality can induce present‐oriented behavior and suggest that perceived economic mobility accounts for this relationship. This study demonstrates that present‐oriented and shortsighted behaviors, which are usually considered characteristics of the poor, can occur due to the perceptions of the environment beyond class. It implies that the macro level of economic inequality can influence an individual's decision making at the micro level.
Shortened consent forms for genome‐wide sequencing: Parent and provider perspectives
Authors: Hitchcock Emma C. , Study CAUSES , Elliott Alison M. 
Published: May 2020

Abstract
BackgroundConsent forms for exome and/or genome sequencing, collectively called genome‐wide sequencing (GWS), frequently contain detailed information on complex topics such as sequencing analysis and incidental findings. Considering recent endeavors by the health care community to simplify GWS consent forms, it is important to gain stakeholders' perspectives on the content, length, and use of consent forms.MethodsThematic analysis was conducted on data obtained from focus groups with two participant cohorts: parents who previously provided consent for trio‐based GWS as part of the translational pediatric GWS CAUSES Study, and genetic health care providers (HCP) who provide pre‐test counseling for GWS.ResultsGenetic HCP indicated that consent forms cannot replace pre‐test counseling, and as such, a simplified consent form focusing on the implications of GWS would be beneficial to both patients and HCP. Although parents' primary concerns varied when considering GWS, they all highly valued information. Parents also indicated the need for community and support after the return of GWS results. Both participant cohorts recommended that consent forms be available online and include an appendix for supplementary information.ConclusionIt is important to include both parents and HCP in the design of GWS consent forms, and also, to help connect families who have a shared diagnosis after the post‐test counseling session.
High‐quality interferometric inverse synthetic aperture radar imaging using deep convolutional networks
Authors: Zhang Ye , Yang Qi , Zeng Yang , Deng Bin , Wang Hongqiang , Qin Yuliang 
Published: May 2020

AbstractIn this article, a modified complex‐valued convolutional neural network (MCV‐CNN) specifically for interferometric inverse synthetic aperture radar (InISAR) imaging is proposed. Comparing with the fast Fourier transformation‐based and sparsity‐driven imaging algorithms, the MCV‐CNN can achieve super‐resolution and side‐lobe suppression on the imaging results simultaneously within a short time. The inputs of the MCV‐CNN are complex‐valued radar echo data, and the outputs are complex‐valued ISAR images which contain both the amplitude and phase information. Then the phase information is adopted to perform an interferometric operation, and the high‐quality three‐dimensional InISAR imaging results can be achieved. A 0.22 THz InISAR imaging experiment has been carried out to show the superiority of the proposed method on imaging quality and computational efficiency.
Profiles of paint layer samples obtained in the fringe field of a high field magnet by means of very short broadband frequency‐modulated pulses
Authors: Taugeron Pierre , Bricaud Sullivan , Kehlet Cindie , Dittmer Jens 
Published: May 2020

AbstractIn this article, we describe the acquisition of depth profiles, in particular of paint layers, in the static gradient of a high field magnet, providing a superior sensitivity. The main objective are reference profiles that help to understand scans made with noninvasive unilateral nuclear magnetic resonance (NMR), which often suffers from poor signal‐to‐noise ratio when working with real samples. Various technical aspects like the coil geometry and the limit of resolution are investigated. A major advancement is the use of frequency‐modulated pulses that are very broadband and at the same time very short (25 μs). The latter is necessary to allow the acquisition of a CPMG echo train of old, rigid paint material. Despite being far from adiabatic, they provide uniform excitation and refocusing over 1 MHz, which corresponds to about 400 μm with the used gradient. We show that the uniformity is even sufficient to obtain biexponential relaxation profiles. With these tools, a paint sample from a restoration campaign is analyzed with different contrast criteria: The original and two layers from former restoration attempts can be visualized, and furthermore, the relaxation profiles allow to study the migration of plasticizing molecules.
Development and Reliability of the Comprehensive Crisis Plan Checklist, 2nd Edition
Authors: McCleary Daniel F. , Aspiranti Kathleen B. 
Published: May 2020

AbstractAs the research base for school crisis intervention and prevention expands, the need for well‐developed tools to assess school readiness in the event of a crisis increases. This paper describes how the Comprehensive Crisis Plan Checklist (CCPC) was updated to reflect advances in crisis management and crisis planning. An extensive literature search and pilot study were used to refine existing items and create new items for the checklist. The Comprehensive Crisis Plan Checklist, 2nd Edition (CCPC‐2) has 102 items separated into three sections: prevention, intervention, and postvention. The CCPC‐2 can be used by crisis teams to create new crisis plans or evaluate existing ones. Users are encouraged to carefully consider the inclusion of all items and articulate why individual items are not necessarily based on their specific needs. The CCPC‐2 was given to 10 pairs of raters to evaluate school‐based crisis plans; average interrater reliability was 89.04%. Discussion focuses on item analysis and how to use the checklist within a school setting.
Cure Kinetics of Silicone/Halloysite Nanotube Composites
Authors: Karami Zohre , Jazani Omid Moini , Navarchian Amir H. , Saeb Mohammad Reza 
Published: May 2020

AbstractProperties of silicone thin films and coatings are strongly hooked on curing reaction. We discussed about cure process of silicone nanocomposites containing halloysite nanotube (HNT) at different loading levels (0.5, 1.0, and 2.0 phr), both qualitatively and quantitatively. Systems containing pristine and aminosilane‐functionalized HNT were cured nonisothermally and heat buildup of the reaction was recorded by differential scanning calorimetry (DSC) in terms of the time and the temperature varying the heating rate. Integral and differential isoconversional methods suggested that apparent activation energy (Ea) was strongly affected by the loading level and surface treatment of HNT. The exponent of the autocatalytic reaction (m) was decreased by the introduction and increasing the amount of pristine, and more remarkably the functionalized HNT to the silicone, where the Friedman method suggested 0.249, 0.119, and 0.045 values of m for the neat silicone rubber, and the nanocomposites containing 1 phr of pristine and functionalized HNT, respectively. The logarithm of frequency factor, ln A was also increased due to the enhanced collisions between curing moieties in the presence of pristine and functionalized HNTs form 23.57 seconds for silicone rubber to 24.25 seconds and 25.19 seconds for silicone nanocomposite containing 2 phr of pristine and functionalized HNT, respectively. The theoretical rate of reaction was in agreement with experimental data.
Nominal exchange rate determination and dynamics in an OLG framework
Authors: Bambi Mauro , Eugeni Sara 
Published: May 2020

AbstractThe empirical evidence on nominal exchange rate dynamics shows a long-run relationship of this variable with the fundamentals of the economy, although such relationship disappears at shorter horizons. This apparently contrasting behaviour of the nominal exchange rate can be explained in an overlapping generations model where the currencies are not perfect substitutes. In this framework, we show that the nominal exchange rate is pinned down by the fundamentals at the monetary steady state. We study the local dynamics and show that when the monetary steady state is locally indeterminate, then fluctuations of the nominal exchange rate around its long-run value can emerge. In particular, we prove the existence of stationary sunspot equilibria, where random fluctuations of the nominal exchange rate arise as a result of self-fulfilling beliefs.
Optical sensors for determination of biogenic amines in food
Authors: Danchuk Alexandra I. , Komova Nadezhda S. , Mobarez Sarah N. , Doronin Sergey Yu. , Burmistrova Natalia A. , Markin Alexey V. , Duerkop Axel 
Published: May 2020

AbstractThis review presents the state-of-the-art of optical sensors for determination of biogenic amines (BAs) in food by publications covering about the last 10 years. Interest in the development of rapid and preferably on-site methods for quantification of BAs is based on their important role in implementation and regulation of various physiological processes. At the same time, BAs can develop in different kinds of food by fermentation processes or microbial activity or arise due to contamination, which induces toxicological risks and food poisoning and causes serious health issues. Therefore, various optical chemosensor systems have been devised that are easy to assemble and fast responding and low-cost analytical tools. If amenable to on-site analysis, they are an attractive alternative to existing instrumental analytical methods used for BA determination in food. Hence, also portable sensor systems or dipstick sensors are described based on various probes that typically enable signal readouts such as photometry, reflectometry, luminescence, surface-enhanced Raman spectroscopy, or ellipsometry. The quantification of BAs in real food samples and the design of the sensors are highlighted and the analytical figures of merit are compared. Future instrumental trends for BA sensing point to the use of cell phone–based fully automated optical evaluation and devices that could even comprise microfluidic micro total analysis systems.
Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis
Authors: Milke Lars , Marienhagen Jan 
Published: May 2020

AbstractMalonyl-CoA is an important central metabolite serving as the basic building block for the microbial synthesis of many pharmaceutically interesting polyketides, but also fatty acid–derived compounds including biofuels. Especially Saccharomyces cerevisiae, Escherichia coli, and Corynebacterium glutamicum have been engineered towards microbial synthesis of such compounds in recent years. However, developed strains and processes often suffer from insufficient productivity. Usually, tightly regulated intracellular malonyl-CoA availability is regarded as the decisive bottleneck limiting overall product formation. Therefore, metabolic engineering towards improved malonyl-CoA availability is essential to design efficient microbial cell factories for the production of polyketides and fatty acid derivatives. This review article summarizes metabolic engineering strategies to improve intracellular malonyl-CoA formation in industrially relevant microorganisms and its impact on productivity and product range, with a focus on polyketides and other malonyl-CoA-dependent products.Key Points• Malonyl-CoA is the central building block of polyketide synthesis.• Increasing acetyl-CoA supply is pivotal to improve malonyl-CoA availability.• Improved acetyl-CoA carboxylase activity increases availability of malonyl-CoA.• Fatty acid synthesis as an ambivalent target to improve malonyl-CoA supply.
A three-headed plantaris muscle: evidence that the plantaris is not a vestigial muscle?
Authors: Olewnik Łukasz , Zielinska N. , Karauda P. , Tubbs R. Shane , Polguj M. 
Published: May 2020

AbstractThe plantaris is a small muscle that typically originates at the lateral supracondylar line of the femur and the knee joint capsule, from where it continues distally, forming a long and slender tendon. However, considerable controversy surrounds the status of this seemingly inconspicuous muscle: is it a residual muscle, or one that it is just developing? In addition, both the proximal and distal attachments are highly morphologically variable. These variations can lead to many diseases. Interestingly, the course of the PM tendon is also variable. The present case study presents a new description of a complex origin type and a rare course of the PM tendon. Understanding of the PM and its tendon has clear clinical value and is a significant indicator of the development of interest in this overlooked muscle.