bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ROLE OF ADIPONECTIN, VISFATIN AND IRISIN IN THE PATHOGENESIS AND TREATMENT OF ARTERIAL HYPERTENSION
Authors: Romaniuk O.T. , Sklyarova H.E. , Tiutiunnyk О.О. , Fomenko I.S. , Sklyarov E.Y. , Kobylinska L.I. , VariShandor G. 
Published: December 2024

Background. The pathogenesis of arterial hypertension is not fully understood, although the main mechanisms of blood pressure regulation are generally outlined. An important role in the pathogenesis of hypertension, in addition to the well-known factors, is played by excessive expression of pro-inflammatory cytokines, which are produced by adipose tissue.
Aim: to determine the role of adiponectin, visfatin and irisin in the pathogenesis and treatment of arterial hypertension.
Materials and methods. 70 patients with arterial hypertension were examined in a randomized manner. Patients were divided into two groups: group 1 - 33 patients with controlled blood pressure and group 2 - 37 people with elevated blood pressure. All study participants underwent a thorough collection of disease and life anamnesis, a general physical examination with measurement of blood pressure (BP), anthropometric measurements with calculation of body mass index (BMI), complete blood count, coagulation test, blood chemistry test, as well as, enzyme-linked immunosorbent assay to determine the level of adiponectin, visfatin, irisin in blood serum and lymphocytes. An echocardiographic examination (EchoCG) was additionally performed.
Results. Patients of the first group with normal blood pressure had significantly higher levels of adiponectin (p ˂ 0.01) and irisin (p ˂ 0.05) in blood serum, as well as significantly lower levels of visfatin in blood serum (p ˂ 0.05) compared to the patients of the second group. On the other hand, in lymphocytes, no significant difference was found between the indicators of adiponectin and visfatin between patients of the first and second groups. A positive correlation was found between the level of visfatin in lymphocytes and age (r=0.308; p ˂0.05), fibrinogen (r=0.472; p ˂0.01) and INR (r=0.551; p ˂0.01), as well as significantly positive correlation of visfatin in blood serum and SBP level (r=0.331; p ˂0.05). A positive relationship was established between adiponectin in serum and in lymphocytes and INR (r=0.303; p ˂0.05) and an inverse relationship between serum irisin indicators and the prothrombin index (r=-0.359; p ˂0.05).
Conclusion. In patients who achieved the target BP range on the background of low concentrations of total cholesterol and LDL cholesterol, serum visfatin, the content of adiponectin was significantly higher compared with patients of group II, in whom higher BP was worse controlled by antihypertensive drugs. Accordingly, patients who did not reach the target BP range had significantly higher levels of visfatin against a background of significantly lower levels of adiponectin and irisin.
The Mediation Effect of Financial Performance on CSR Disclosure and GCG on Firm Value during the Pandemic
Authors: Quranni Nazillatul Ismi , Arifah Dista Amalia 
Published: December 2024

This research aims to determine the effect of CSR Disclosure and CGC with profitability as a mediating variable on company value. This research was conducted to see how CSR and GCG affect company value during the pandemic. To test this variable, researchers used a population of all companies registered with the Kompas100 companies listed on the Indonesia Stock Exchange (BEI) in 2020. Using purposive sampling, the total sample taken was 86 companies. Hypothesis testing is carried out using descriptive analysis methods with multiple linear regression techniques. The research results show that CSR disclosure does not significantly affect financial performance and company value. The results also show that GCG positively and significantly affects financial performance and company value. Financial performance also influences company value but cannot mediate CSR Disclosure and GCG on company value.
Mutu Fisikokimia dan Organoleptik Kerupuk Ikan Nike (Awaous melanocephalus) dengan Penambahan Pewarna Alami Ekstrak Daun Bayam Hijau
Authors: Suna Sri Devi , Kiay Nancy , Abdullah Sofyan , Abdullah Fadhil , Basri Bayu Setiawan , Riastutik Desak Nyoman 
Published: December 2024

Ikan nike merupakan salah satu spesies ikan yang ditemukan diperairan Gorontalo yang berasal dari kelompok gobiidae. Produksi ikan nike cukup melimpah dan memiliki rasa daging yang khas namun memiliki harga yang murah jika musimnya tiba. Sedangkan pemanfaatannya masih terbatas hanya untuk konsumsi sehari-hari. Oleh sebab itu, salah satu upaya untuk memaksimalkan pemanfaatnnya adalah dijadikan olahan seperti kerupuk dengan penambahan pewarna alami dari ekstrak daun bayam hijau. Tujuan penelitian ini untuk mengetahui penambahan ekstrak daun bayam hijau terhadap mutu fisikokimia dan organoleptik kerupuk ikan nike yang dihasilkan. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan (K0 : kontrol, K1: Ekstrak Daun Bayam Hijau 4,5%, K2: Ekstrak Daun Bayam Hijau 6,5%, K3: Ekstrak Daun Bayam Hijau 8,5%) dengan 3 kali ulangan. Kerupuk yang dihasilkan kemudian di uji kandungan kadar air, kadar abu, kadar lemak, warna, daya kembang, daya serap minyak dan uji organoleptik (warna, aroma, rasa dan tekstur). Hasil penelitian menunjukkan bahwa kerupuk ikan nike berpengaruh nyata terhadap uji warna a* dengan warna putih ke abu-abuan. Sedangkan uji kimia yaitu kadar abu dan kadar lemak perlakuan kontrol tanpa penambahan pewarna daun bayam memiliki nilai terbaik. Sedangkan nilai organoleptik semua perlakuan tidak menujukkan adanya pengaruh nyata di mana semua perlakuan memiliki kriteria agak suka.
Parents' Opinion on the Effects of Aquatic Physiotherapy on Delayed Motor Development in Infants
Authors: Klovaitė Austėja 
Published: December 2024

Background. Aquatic therapy is commonly utilized in the rehabilitation of children with developmental disabilities and as a form of physical activity in water for children without developmental disabilities.
The aim. To analyze parents' opinions regarding the impact of physiotherapy in water on the delayed motor development of babies aged 2–9 months.
Methods. Ten parents whose babies were diagnosed with motor developmental disorders and received aquatic physical therapy for motor developmental delay were interviewed during the study. A semi-structured interview comprising 18 questions was employed in the qualitative study.
Results. The study revealed that parents often notice developmental disorders in their babies when they fail to achieve age-appropriate milestones, leading to later diagnosis by doctors. Following the diagnosis of motor development disorders, doctors recommended various treatment methods to the participants. While parents primarily selected physiotherapy as the main treatment method, they also opted for aquatic physiotherapy as an additional approach for enhanced effectiveness. The Halliwick method was commonly employed to address motor development disorders. Almost all participants expressed willingness to recommend aquatic physiotherapy to friends or acquaintances if their children were diagnosed with motor development disorders.
Conclusions. Parents emphasized that water physiotherapy improved their babies' motor skills and had a calming and relaxing effect. Most interviewees indicated a positive inclination towards recommending aquatic physiotherapy, considering it an effective intervention.

Keywords: physical therapy in water, motor development, parents, attitudes, babies.
Extra Physical Activities Positively Affect Balance in Children Aged 5–11 Years
Authors: Nur Surucu Elif , Budrienė Lina 
Published: December 2024

Background. Extra-physical activities (EPA) are necessary for children because they contribute to the development of motor skills and general development.
The aim. To evaluate the effect of EPA on balance, measured with the Bruininks-Oseretsky Test-2 (BOT-2), in children aged 5–11 years old.
Methods. This study was designed as a cross-sectional study. Children (n = 68) aged 5–11 years were divided into two groups depending on the activity they participated in. 36 children participated in standard physical education (physical education group, PEG) lessons, and 32 children attended extra-physical activities (EPA). Nine subscales of the BOT-2 balance test were evaluated and compared between balanced PEG and EPA.
Results. An independent sample t-test revealed a significant difference in balance between PEG and EPG (t (66) = -2.2, p = 0.02), with EPG being greater than PEG. A Kruskal-Wallis test revealed no difference in EPA specificity (H = 3.62, df = 6, p = 0.72) or the EPA participation frequency (H (4) = 0.93, p = 0.92).
Conclusion. The extra physical activity group performed better in balance than the physical education group. This finding suggests a role for extra physical activity in promoting balance. The frequency and specificity of participation in extra-physical activities did not influence the balance.
Keywords: balance, motor skills, motor development, physical activity
Pengaruh Kinerja Keuangan Perusahaan dan Kepemilikan Institusional terhadap Tax Avoidance
Authors: Rini Dena Setya , Nurhayati Nurhayati 
Published: December 2024

ABSTRACT
This study aims to analyze the effect of company financial performance and institutional ownership on tax avoidance. This type of research is quantitative associative with secondary data sources. The population in this study is energy sector companies listed on the Indonesia Stock Exchange in 2018-2022. The data analysis technique in this study is the purposive sampling method, namely a technique that considers criteria, so that the sample obtained with this method is 10 companies. The results of the study show that the company's financial performance and institutional ownership have an effect on tax avoidance. Then, partially the company's financial performance variable has no effect on tax avoidance. While the institutional ownership variable has a negative effect on tax avoidance. These results are because the higher the institutional ownership, the lower the level of tax avoidance actions taken by the company.

ABSTRAK
Penelitian ini bertujuan untuk menganalisis pengaruh kinerja keuangan perusahaan dan kepemilikan institusional terhadap tax avoidance. Jenis penelitian ini adalah kuantitatif asosisatif dengan sumber data sekunder. Populasi dalam penelitian ini adalah Perusahaan sektor energi yang terdaftar di Bursa Efek Indonesia tahun 2018-2022. Teknik analisis data dalam penelitian ini adalah metode purposive sampling yaitu teknik dengan memperhatikan kriteria, sehingga sampel yang didapatkan dengan metode tersebut 10 perusahaan. Hasil penelitian menunjukan bahwa kinerja keuangan perusahaan dan kepemilikan institusional berpengaruh terhadap tax avoidance. Kemudian, secara parsial variabel kinerja keuangan perusahaan tidak berpengaruh terhadap tax avoidance. Sedangkan variabel kepemilikan institusional berpengaruh negatif terhadap tax avoidance. Hasil tersebut karena semakin tinggi kepemilikan institusional maka, semakin rendah tingkat tindakan tax avoidance yang dilakukan oleh perusahaan.
Keywords:Company Financial Performance, Institusional Ownership, Tax Avoidance
Cardiac function in pregnant women with preeclampsia
Authors: Yerlikaya-Schatten Gülen , Karner Eva , Heinzl Florian , Prausmüller Suriya , Kastl Stefan , Springer Stephanie , Zilberszac Robert 
Published: December 2024

IntroductionPreeclampsia (PE) is thought to be the consequence of impaired placental perfusion leading to placental hypoxia. While it has been demonstrated that PE may be a consequence of maternal cardiovascular maladaptation, the exact role of maternal cardiac function remains to be determined. This study sought to assess cardiac characteristics in pregnant women diagnosed with PE and to determine the possible relationship between PE, maternal cardiac changes/function, and NT-proBNP levels.MethodsThis was a retrospective analysis of 65 pregnant women diagnosed with PE who had an echocardiographic examination during pregnancy. Where available, NT-proBNP levels were analyzed. All patients underwent a comprehensive echocardiographic examination based on a standardized examination protocol.ResultsLeft ventricular size was within the normal range, and there was normal radial left ventricular function. Longitudinal contractility was impaired with a global longitudinal strain of −17.8% (quartiles −20.2 to −15.4). The cardiac index was in the normal range with a median of 3.2 ml/min/m2 (quartiles 2.6–4.0). The left atrium was of borderline size in longitudinal diameter [50 (44.8–54.3) mm], but within the normal range in volumetric index [27.3 (22.9–37.3) ml/m2]. Furthermore, mild left ventricular hypertrophy [septal thickness 12 (10–13) mm] and at least borderline elevated filling pressures with an E/e' ratio of 10.6 (8.5–12.9) were found. Maximal tricuspid regurgitation velocity [2.9 (2.5–3.3) m/s] and derived systolic pulmonary pressure [38 (29.5–44.5) mmHg] were borderline elevated. Regarding NT-proBNP levels, an increase in NT-proBNP levels correlated with a decrease in gestational age at delivery (p &lt; 0.0002) and maternal cardiac changes. Obstetric characteristics showed a preterm rate of 71.43%, mostly due to maternal aggravation of PE or because of fetal signs of deprivation based on placental insufficiency. Neonatal deaths occurred in five cases (7.69%).ConclusionChanges in cardiac function in the context of hypertensive pregnancy diseases can be observed with regard to various echocardiographic parameters. Furthermore, there is a significant association between NT-proBNP levels and a decrease in gestational age at delivery in women with PE, which thus might be useful as a prognostic factor for the management of women with preeclampsia and changes in maternal cardiac function during pregnancy.
Addressing Known hypertensive disOrders of pregnancy in woMen of African descent in Canada (AKOMA): protocol for a mixed method study
Authors: Baiden Deborah , Nerenberg Kara , Hillan Edith M. , Dogba Maman Joyce , Parry Monica 
Published: December 2024

BackgroundHypertensive disorders of pregnancy (HDP) predispose a woman to maternity-related cardiovascular morbidity and mortality. However, there is limited literature on HDP among women of African descent in Canada.Methods and designA convergent mixed-method study will be used to investigate the intersection of self-reported HDP risks in women of African descent in Canada with a history of a HDP (quantitative, cross-sectional survey) and explore the perception and experiences of women of African descent living in Canada with a history of a HDP in relation to the intersection of risk factors (critical qualitative inquiry, interviews). Quantitative analysis will use SPSS V. 27.0 and thematic analysis will be conducted using NVivo V. 12. A joint display will be used to combine the quantitative and qualitative results.DiscussionThrough the lens of intersectionality, the proposed study aims to provide a comprehensive understanding of the intersection of risks for HDP among women of African descent in Canada with a history of HDP. Furthermore, results could inform future strategies to reduce cardiovascular disease risks.
Trial Registration NumberThis is registered in the Open Sciences Framework as follows: https://doi.org/10.17605/OSF.IO/R6CKY.
Case Report: Avoiding misdiagnosis in amyloidosis—navigating transthyretin genopositivity and monoclonal gammopathy in a patient with advanced heart failure and spinal stenosis
Authors: Wu Xia , Toskic Denis , Zhou Ping , Scalia Stephanie , Ma Xun , Bhatt Parva , Fogaren Teresa , Pilichowska Monika , Arkun Knarik , Patel Jainith , Riesenburger Ron I. , Larson Daniel P. , Comenzo Raymond L. 
Published: December 2024

BackgroundA 63-year-old Black woman presented with progressive exertional dyspnea and chronic lower back pain. The course and findings in her case are instructive.Case reportFamily history was notable for cardiac deaths. An echocardiogram demonstrated ventricular wall thickening with diastolic dysfunction. The patient’s N-terminal pro b-type natriuretic peptide level was 1,691 pg/ml with a troponin I level of 0.36 ng/ml. Transthyretin (TTR) sequencing detected a heterozygous V122I variant. The patient’s free κ light chain level in serum was 664 mg/L with a ratio of 16.5. Bone marrow analysis showed 20%–30% κ-restricted plasma cells with amyloid deposits. A technetium-99m sodium pyrophosphate scan was performed and was negative. Magnetic resonance imaging of the total spine showed ligamentum flavum (LF) thickening at L4–5, causing severe spinal stenosis. In both the abdominal fat and the LF, liquid chromatography-coupled tandem mass spectrometry confirmed κ-type immunoglobulin light chain (AL) amyloidosis; the quantitative estimate of amyloid content in the LF was 5%. She was diagnosed with AL amyloidosis with Mayo Stage IIIA cardiac and soft tissue involvement, enrolled in the Aquarius trial (NCT05250973) in Cohort 2, and received daratumumab, cyclophosphamide, bortezomib, and dexamethasone. She achieved a partial hematological response with a cardiac response and is now pain-free and fully functional.ConclusionIn patients with amyloidosis who have both monoclonal gammopathy and a TTR variant, it is imperative to discern the tissue type of the amyloid to deduce the correct diagnosis. ATTR and AL amyloidosis can both cause spinal stenosis with minimal degenerative changes. The LF tissue must be stained for amyloids and, if present, typing must be performed.
Association between physical activity and sedentary behavior and gestational diabetes mellitus: a Mendelian randomization analysis
Authors: Gao Jie , Liu Jingfang 
Published: December 2024

IntroductionThe evidence of association between physical activity (PA), sedentary behavior (SB) and gestational diabetes mellitus (GDM) remains controversial in observational studies, this study aimed to generate new hypotheses between PA, SB and GDM.MethodsOur study performed Mendelian randomization (MR) analysis to explore the effects of three types of PA (moderate physical activity (MPA), moderate to vigorous physical activity (MVPA), accelerometer-based physical activity (ABPA)), three types of SB (television watching (TV), leisure computer use (PC), driving (DR)) on GDM and the mediating effect of body mass index (BMI). The inverse variance weighted method was used for the major analysis.ResultsIn univariate MR analysis, we found that genetically predicted TV and PC among SB were associated with GDM (OR = 1.61, 95%CI 1.21-2.14, P = 0.001; OR = 0.71, 95%CI 0.51-0.98, P = 0.037), whereas DR and MP were not (OR = 1.68, 95%CI 0.21-13.3, P = 0.623; OR = 1.20, 95%CI 0.87-1.65, P = 0.271). However, no association was found between physical activity and GDM: MPA (OR = 0.40, 95%CI 0.08-2.06, P = 0.273), MVPA (OR = 0.96, 95%CI 0.58-1.57, P = 0.861), and ABPA (OR = 0.99, 95%CI 0.90-1.09, P = 0.838). Multivariate MR analysis found DM (OR = 1.64, 95%CI 1.13-2.36, P = 0.008) and that BMI was a mediating factor with a 62% mediating effect.ConclusionsThis study proposes a new hypothesis for the association between TV and GDM, which is mediated by BMI, providing evidence for reducing the risk of GDM during pregnancy by reducing television watching time.
Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF
Authors: Xie Qin , Jiang Xueyi , Zhao Ming , Xie Yating , Fan Yong , Suo Lun , Kuang Yanping 
Published: December 2024

BackgroundTechniques for sperm cryopreservation have exhibited their potential in male fertility preservation. The use of frozen–thawed sperm in in vitro fertilization (IVF) cycles is widespread today. However, many studies reported that cryopreservation might have adverse effects on sperm DNA integrity, motility, and fertilization, probably due to cold shock, intra- and extracellular ice crystals, and excess reactive oxygen species (ROS). Studies suggested that freezing and thawing impaired sperm viability and might adversely affect subsequent fertilization and pregnancy outcomes. The potential damage to fertilization and subsequent embryonic development and offspring health raises the concern on sperm cryopreservation. However, the above mentioned studies are limited to intracytoplasmic sperm injection (ICSI) cycles, while IVF is a more natural and patient-friendly method. IVF requires a higher quality of sperm than ICSI. However, the effect of freezing and thawing on sperm used for IVF remains unknown. Therefore, we aim to investigate the effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF.MethodsThis retrospective cohort study at a tertiary-care academic medical center included 447 women who used paternal frozen–thawed ejaculated sperm and 31,039 women who used paternal freshly ejaculated sperm for IVF and underwent frozen–thawed blastocyst transfer from January 2011 to September 2021. To balance the baseline characteristics of the two groups, patients using frozen sperm were matched with control groups using a propensity score matching algorithm with a ratio of 1:3.ResultsAlthough sperm motility decreased from 82.04% to 75.70% (P &lt; 0.001) after the freezing–thawing process, the fertilization rate (68.27% for frozen sperm and 67.54% for fresh sperm), number of viable embryos (1.98 and 2.16), clinical pregnancy rate (44.7% and 51.8%), and live birth rate (40.3% and 42.4%) were comparable between the two groups (all P &gt; 0.05). For neonatal outcomes, no between-group differences were observed in offspring gender, gestational age, birthweight, and the rate of preterm birth (21.7% and 12.9%), low birthweight neonates (19.2% and 16.0%), and birth defects (0.0% and 0.8%) (all P&gt;0.05).ConclusionsFrozen–thawed sperm had lower sperm motility but resulted in comparable embryonic, pregnancy, and neonatal outcomes versus fresh sperm in IVF cycles.
Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents
Authors: Schierloh Ulrike , Aguayo Gloria A. , Fichelle Muriel , De Melo Dias Cindy , Schritz Anna , Vaillant Michel , Barnard-Kelly Katharine , Cohen Ohad , Gies Inge , de Beaufort Carine 
Published: December 2024

AimsTo compare impact of pump treatment and continuous glucose monitoring (CGM) with predictive low glucose suspend (SmartGuard) or user initiated CGM (iscCGM) on sleep and hypoglycemia fear in children with type 1 Diabetes and parents.MethodsSecondary analysis of data from 5 weeks pump treatment with iscCGM (A) or SmartGuard (B) open label, single center, randomized cross-over study was performed. At baseline and end of treatment arms, sleep and fear of hypoglycemia were evaluated using ActiGraph and questionnaires.Results31 children (6-14 years, male: 50%) and 30 parents (28-55 years) participated. Total sleep minutes did not differ significantly for children (B vs. A: -9.27; 95% CI [-24.88; 6.34]; p 0.26) or parents (B vs. A: 5.49; 95% CI [-8.79; 19.77]; p 0.46). Neither daytime sleepiness nor hypoglycemia fear in children or parents differed significantly between the systems. Neither group met recommended sleep criteria.ConclusionLack of sleep and fear of hypoglycemia remain a major burden for children with diabetes and their parents. Whilst no significant differences between the systems were found, future technology should consider psychosocial impacts of diabetes and related technologies on children and parents’ lived experience to ensure parity of esteem between physical and mental health outcomes.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT03103867.