bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Innovative and Integrated Reservoir Characterization Driven by Modified Saturation Height Model and Variable Fluid Contacts for Challenging Complex Sandstone Reservoir
Authors: Gibrata Muhammad A. , Ghedan Shawket G. , Rouis Lamia , Djanuar Yanfidra 
Published: October 2019

Abstract
It has been known that the uncertainty of original oil in place (OOIP) is one of main challenges in proper reservoir development. The field has complex reservoir subunits, variable fluid contacts and structural and stratigraphic sand discontinuities. Therefore, reliable reservoir characterization and estimation of fluids in place requires an integrated approach of all available data of petrophysical evaluation, special core analysis (SCAL), geology, geophysics, reservoir rock typing (RRT), saturation height model (SHM) and fluid analysis.
An innovative and integrated petrophysical evaluation have been studied and used in reservoir characterization. An advanced permeability log has been developed from porosity, clay bound, pore size, core and mobility data. It has used the modification of SHM that based on SCAL data including MICP, Centrifuge, Porous Plate and Relative Permeability data for every RRT and variable fluid contacts for subunits. An initial water saturation, and residual oil saturation from SCAL data have been used in evaluation. The pulse neutron capture and PLT have been used to verify fluid contacts and water saturation changes in complex sandstone reservoirs during production.
The advanced integrated evaluation approach of subsurface and well test data has been used to provide reliable and good of reservoir properties and results on porosity, permeability, fluid contacts, reservoir rock typing and initial water saturation initial oil in place. For every reservoir subunits, the free water level (FWL) derived from formation pressure has been used to identify an initial oil water contact, and thus it has provided good comparison of Log-Sw and SHF derived Sw for reservoir modeling. The study has provided reliable reservoir characterization, reservoir modeling and for the development for multi-layer and complex sandstone reservoirs. Therefore the innovative integrated reservoir evaluation approach has provided reliable assurance and important benefits for reservoir characterization, optimization and reservoir management.
The integrated approach presented in this paper presents an advanced step in the characterization of very flower shaped faulted complex reservoir. It has been utilized for the derivation of advanced permeability log as function of porosity, clay bound, pore size and mobility data per different rock types. Integration of available petrophysical, pressure, and SCAL data to derive the variable reservoir fluid contacts, and develop SHFs for fluids in place estimation and reservoir modeling purposes.
Stimulating Long Horizontal Polymer Injectors with Hoist: A Case Study from South Sultanate of Oman
Authors: Harrasi Ameera , Urdaneta Gerardo , Al-Jumah Ali , Nasif Mohammed , Qassabi Hajir 
Published: October 2019

Abstract
The multidisciplinary Authors summarize the lessons learned from stimulating a long horizontal Polymer Injection well with a Hoisting Unit; the main objective was to reduce the associated cost as compared to a Coiled Conventional Tubing (CCT) Unit, but achieving the same or even improved results. The details procedures for conducting this type of job is summarized in this paper.
The well was completed with a smart completion, creating four distinguished zones, Earlier, bullheading approach was carried out, but later on when the smart completion failed, it was necessary to stimulate with a CCT to cover all the different zones in the long well section. This has caused a sharp increase in the price of the job. Hence, a trial has been carried out utilizing a Hoist, with improved acid recipe that is cheaper and better in performance as compared to earlier. The detailed procedure for conducting this type of job is summarized in this paper
The tables show the injectivity test result in three stages, in the Hoist and the CCT approach the result shows a good improvement after main treatment and a success of the trial with Hoist as compared to CCT. This has proven to be economically viable and unlocked huge cost savings for all future stimulation jobs. A 50% reduction in the total cost is observed. This work has concluded a successful methodology in the utilization of a hoist in performing multi-stage stimulation in long horizontal wells. Very encouraging results have been observed and the suggested method is highly recommended, further trials will continue to be done with other wells
The authors believe the learnings from these trials are of great benefit and will add to the state of knowledge of the industry relating to stimulating long horizontal wells
Technology Management System TechRoad for a Technology Driven Company
Authors: Akoum Mohamed , Abdallah Dalia , Grandi Andrea 
Published: October 2019

Abstract
Adoption of new technologies is a key enabler towards retaining competitiveness, taking full advantage of market opportunities to achieve ADNOC's 2030 smart growth strategy. TechRoad is an innovative in-house built solution that fully automates and streamlines the technology-adoption business process from technology registration to evaluation, piloting and deployment. Originally developed by ADNOC Onshore as an advanced technology management system and a decision making tool to generate the required technology roadmaps for our business challenges, ADNOC Management has recognized TechRoad as a progressive tool for incorporation across ADNOC's value chain. Launched in late 2018, and acclaimed by technology providers, TechRoad's registration portal was the first step taken towards ADNOC corporate integration.
Music to improve sleep quality in adults with depression related insomnia (MUSTAFI): Study protocol for a randomized controlled trial
Authors: Lund Helle Nystrup , Pedersen Inge Nygaard , Johnsen Søren Paaske , Heymann-Szlachcinska Agnieszka Maria , Tuszewska Maryla , Bizik Gustav , Larsen Jens Ivar , Kulhay Eszter , Larsen Anelia , Grønbech Bettina Ellen , Østermark Helle , Borup Heidi , Valentin Jan Brink , Mainz Jan 
Published: October 2019

Abstract
Abstract Background Insomnia is a common sleep disorder for adults with depression with major impact on the quality of life. Previous trials suggest that music listening may be helpful in the treatment of sleep disturbances in healthy populations including students and elderly. In addition, small studies with clinical populations of traumatized refugees, adults with chronic insomnia and adults with depression insomnia add to the evidence base. However, the impact of music listening in the treatment of depression related insomnia is not well documented. Objective To examine the efficacy of music listening on sleep quality, symptoms of depression and quality of life in adults with depression related insomnia. Method A single center randomized controlled trial (RCT) in a two arm parallel group design is conducted and reported according to the Consort guidelines. The trial consists of an experimental group and a standard care control group. Both groups receive standard treatment for depression following Danish guidelines in an outpatient unit in psychiatry. The experimental group listen to music minimum 30 minutes at bedtime in four weeks. Discussion This study will provide information on the efficacy of music intervention as a non-pharmacological intervention in the treatment of depression related insomnia. This study will provide novel knowledge concerning music medicine as an evidence based treatment of depression in psychiatry. Trial Registration: Clinicaltrials.gov. ID NCT03676491, registered on 19th of September 2018. Keywords: Music, insomnia, depression, sleep
Interventions to Improve Discharge from Acute Adult Mental Health Inpatient Care to the Community: Systematic Review and Narrative Synthesis
Authors: Tyler Natasha , Wright Nicola , Waring Justin 
Published: October 2019

Abstract
Background: The transition from acute mental health inpatient care to community care is often a vulnerable period in the pathway, where people can experience additional risks and anxiety. Researchers globally have developed and tested a number of interventions that aim to improve continuity of care and safety in the transitions. However, there has been little attempt to compare and contrast the interventions and specify the variety of safety threats they attempt to resolve.

Methods: The study aimed to identify the evidence base for interventions to support continuity of care and safety in the transition from acute mental health inpatient service to community care services at the point of discharge. Electronic Databases including PsycINFO, MEDLINE, Embase, HMIC, CINAHL, IBSS, Cochrane Library Trials, ASSIA, Web of Science and Scopus, were searched between 2000 and May 2018. Peer reviewed papers were eligible for inclusion if they addressed adults admitted to an acute inpatient mental health ward and reported on health interventions surrounding discharge from the acute ward to the community. The results were analysed using a narrative synthesis technique.
Results: The total number of papers from which data was extracted was 45. The review found various interventions implemented across continents, addressing problems related to different aspects of discharge. Some interventions followed a distinct named approach (i.e. Critical Time Intervention, Transitional Discharge Model) others were grouped based on key components (i.e. peer support, pharmacist involvement). The primary problems interventions looked to address were reducing readmission, improving wellbeing, reducing homelessness, improving treatment adherence, accelerating discharge, reducing suicide. The 69 outcomes reported across studies were heterogeneous, meaning it was difficult to conduct comparative quantitative meta-analysis or synthesis.
Conclusions: The interventions reviewed are spread across a spectrum ranging from addressing a single problem within a single agency with a single solution, to multiple solutions addressing multi-agency problems. We recommend that future research attempts to improve homogeneity in outcome reporting.
Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany
Authors: Graf Jonas , Hartmann Christian , Lehmann Helmar C , Otto Carolin , Adams Ortwin , Karenfort Michael , Schneider Christian , Ruprecht Klemens , Bosse Hans Martin , Diedrich Sabine , Böttcher Sindy , Schnitzler Alfons , Hartung Hans-Peter , Aktas Orhan , Albrecht Philipp 
Published: October 2019

Abstract
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges.
OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1 st and December 31 st , 2013 in order to scrutinize clinical differences from other aseptic meningitis cases.
RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and one EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home.
CONCLUSION: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.
Association of Daily Copayments with Use of Hospital Care among Medicare Advantage Enrollees
Authors: McHugh John , Keohane Laura , Grebla Regina , Lee Yoojin , Trivedi Amal 
Published: October 2019

Abstract
Background: While the traditional Medicare program imposes a deductible for hospital admissions, many Medicare Advantage plans have instituted per-diem copayments for hospital care. Little evidence exists about the effects of changes in cost-sharing for hospital care among the elderly. Changing inpatient benefits from a deductible to a per diem may benefit enrollees with shorter lengths of stay, but adversely affect the out-of-pocket burden for hospitalized enrollees with longer lengths of stay. Methods: We used a quasi-experimental difference-in-differences study to compare longitudinal changes in proportion hospitalized, inpatient admissions and days per 100 enrollees, and hospital length of stay between enrollees in MA plans that changed inpatient benefit from deductible at admission to per diem, intervention plans, and enrollees in matched control plans – similar plans that maintained inpatient deductibles. The study population included 423,634 unique beneficiaries enrolled in 23 intervention plans and 36 matched control plans in the 2007-2010 period. Results: The imposition of per-diem copayments were associated with adjusted declines of 1.3 admissions/100 enrollees (95% CI -1.8 to -0.9), 6.9 inpatient days/100 enrollees (95% CI -10.1 to -3.8) and 0.7 percentage points in the probability of hospital admission (95% CI -1.0 to -0.4), with no significant change in adjusted length of stay in intervention plans relative to control plans. For persons with 2 or more hospitalizations in the year prior to the cost-sharing change, adjusted declines were 3.5 admissions/100 (95% CI -8.4 to 1.4), 31.1 days/100 (95% CI -75.2 to 13.0) and 2.2 percentage points in the probability of hospitalization (95% CI -3.8 to -0.6) in intervention plans relative to control plans. Conclusions: Instituting per-diem copayments was associated with reductions in number of admissions and hospital stays, but not length of stay once admitted. Effects of inpatient cost-sharing changes were magnified for persons with greater baseline use of hospital care.
Palliative care training addressed to hospital healthcare professionals by palliative care specialists: a mixed-method evaluation
Authors: Artioli Giovanna , Bedini Gabriele , Bertocchi Elisabetta , Ghirotto Luca , Cavuto Silvio , Costantini Massimo , Tanzi Silvia 
Published: October 2019

Abstract
Background

Despite the great advances in the concept of palliative care (PC) and its benefits, its application seems to be delayed, leaving unfulfilled the many needs of patients and family members. One way to overcome this difficulty could be to develop a new training programme by palliative care specialists to improve PC primary skills in healthcare professionals. The aim of this study was to evaluate the training's impact on trainees within a hospital setting using Kirkpatrick’s and Moore's models.

Methods

We adopted a mixed-method evaluation with concurrent triangulation. The evaluation followed the first three steps of Kirkpatrick’s and Moore’s models and included a pre- and post-training evaluation through self-administered questionnaires and focus groups. We used the McNemar statistical test.

Results

The results highlighted the significant amount of knowledge acquired by the hospital professionals after training, in terms of increasing their knowledge of palliative care and in terms of the change in meaning that they attributed to phenomena related to chronicity and incurability, which they encounter daily in their professional practice. In both quantitative and qualitative research, the results, in synthesis, highlight: (i) the development of a new concept of palliative care, centred on the response to the holistic needs of people; (ii) that palliative care can also be extended to non-oncological patients in advanced illness stages (our training was directed to Geriatrics and Nephrology/Dialysis professionals); (iii) the empowerment and the increase in self-esteem that healthcare professionals gained, from learning about the logistical and structural organization of palliative care, to activate and implement PC; (iv) the need to share personal aspects of their professional life (this result emerges only in qualitative research);

(v)

the appreciation of cooperation and the joining of multiple competences towards a synergistic approach and enhanced outcomes.

Conclusion

It is necessary to further develop rigorous research on training evaluation, at the most complex orders of the Kirkpatrick and Moore models, to measure primary PC skills in health care professionals. This will develop the effectiveness of the integration of I- and II-level palliative care competencies in hospitals and improve outcomes of patients’ and families’ quality of life.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance
Authors: Yu Xiaoling , Zhang Wen , Zhao Zhiping , Ye Chengsong , Zhou Shuyan , Wu Shaogui , Han Lifen , Han Zhaofang , YE HANHUI 
Published: October 2019

Abstract
Background The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation to study gene phenotypes and resistance-associated genes of emergence regarding the CRKP strains. In current study, seven inpatients are enrolled in the hospital with complete treatments. The carbapenem-resistant K. pneumoniae whole genome is sequenced using MiSeq short-read and Oxford Nanopore long-read sequencing technology. Prophages are identified to assess genetic diversity within CRKP genomes. Results The investigation encompassed eight CRKP strains that collected from the patients enrolled as well as the environment, which illustrate that blaKPC-2 is responsible for phenotypic resistance in six CRKP strains that K. pneumoniae sequence type (ST11) is informed. The plasmid with IncR, ColRNAI and pMLST type with IncF[F33:A-:B-] co-exist in all ST11 with KPC-2-producing CRKP strains. Along with carbapenemases, all K. pneumoniae strains harbor two or three extended spectrum β-lactamase (ESBL)-producing genes. fosA gene is detected amongst all the CRKP strains. The single nucleotide polymorphisms (SNP) markers are indicated and validated among all CRKP strains, providing valuable clues for distinguishing carbapenem-resistant strains from conventional K. pneumoniae. Conclusions ST11 is the main CRKP type, and blaKPC-2 is the dominant carbapenemase gene harbored by clinical CRKP isolates from current investigations. The SNP markers detected would be helpful for characterizing CRKP strain from general K. pneumoniae. The data provides insights into effective strategy developments for controlling CRKP and nosocomial infection reductions.
Identification of hub genes and important pathways in determination of breast cancer survival using bioinformatics approaches
Authors: Dashti Sepideh , Ghafouri-Fard Soudeh 
Published: October 2019

Abstract
Backgrounds Breast cancer is a highly heterogeneous disorder characterized by dysregulation of expression of numerous genes and cascades. The conventional pathologic classification of breast cancer is not sufficient for the prediction of breast cancer behavior and response to therapy.Methods We have retrieved data of two microarray datasets (GSE65194 and GSE45827) from the NCBI Gene Expression Omnibus database (GEO). R package was used for identification of differentially expressed genes (DEGs), assessment of gene ontology (GO) and pathway enrichment evaluation. The DEGs were integrated to construct a protein-protein interaction (PPI) network. Next, hub genes were recognized using the Cytoscape software and lncRNA-mRNA co-expression analysis was performed to evaluate the potential roles of lncRNAs. The interactive information among DEGs and the PPI network was obtained using the STRING online database. Finally, the clinical importance of the obtained genes was assessed using Kaplan-Meier survival analysis.Results After excluding the outliers from the GSE65194 and GSE45827 datasets and data normalization, 866 DEGs including 712 upregulated and 154 downregulated DEGs were detected between breast cancer and normal samples. Up-regulated DEGs were enriched in six pathways including ‘Cell cycle’, ‘Oocyte meiosis’ and ‘Focal adhesion’. Down-regulated DEGs were enriched in five pathways including ‘Peroxisome-proliferator-activated receptors (PPAR) signaling pathway’, ‘Metabolism of xenobiotics by cytochrome P450’, ‘Adipocytokine signaling pathway’ and ‘Cytokine-cytokine receptor interaction’ pathways. CCNA2, CDK1, MAD2L1, and CCNB2 were significantly enriched in several biological pathways. These four genes showed strong expression in breast cancer samples as compared to normal breast tissue. We also identified 12 lncRNAs with a significant correlation with MAD2L1 and CCNB2 genes. MAD2L1, CCNA2, RAD51-AS1, and LINC01089 have the most prediction potential among all candidate hub genes.Conclusion Our study offers a framework for recognition of the mRNA-lncRNA network in breast cancer and the detection of important pathways that could be used as therapeutic targets in this kind of cancer.
Combination therapy and survival time in Adult T cell Leukemia/Lymphoma (ATLL)
Authors: Borojerdi Zahra Rezaei , Rahimi Hossein , Ghezeldasht Sanaz Ahmadi , Shirdel Abbas , Allahyari Abolghasem , Sharebiani Hiva , Sabet Faezeh , Mozaheb Zahra , Bary Alireza , Mohades Seyyedeh Tahereh , Azimi Sajad Ataei , Tarokhian Hanieh , Rezaee S.A.Rahim 
Published: October 2019

Abstract
Background: The urgent need for the treatment of ATLL has highlighted in 18th-International Conference on Human Retrovirology-HTLV-1 (Tokyo, 2017). Therefore, in this study the median survival times (MST) of routine therapies for ATLL were evaluated in context of laboratory tests . Methods: In a perspective-retrospective cohort study, the efficiencies of therapy regimens, including interferon-alfa and zidovudine (IFN/ZDV), cyclophosphamide, vincristine, doxorubicin, dexamethasone (hyper-CVAD), lenalidomide/ZDV, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were evaluated in 67 acute ATLL patients. The demographic, clinical, MST, and routine and molecular laboratory data were then collected and analyzed . Results: The MST for acute and lymphoma subjects was 5 and 11 months, respectively, including 5 months (95% CI 3.378 6.622) for IFN/ZDV, 5 months (95% CI 2.067.94) for CVAD, 3months (95% CI 0.009.86) for lenalidomide/ZDV and 11 months (95%CI 8.45913.54) for CHOP regimen. Importantly, patients who received IFN/ZDV and hyper-CVAD therapy, had a better OS (HR, 0.663; 95%CI, 0.540 to 0.814; P=0.0001), compared with the lenalidomide /ZDV alone. The MST for subjects with hypercalcemia was 5 months, and for patients with normal calcium level was 9 months (p=0.017). Conclusions: High expressions of BIM and CERB were more frequent in lymphomatous type, and considering these factors, platelet counts and HTLV-1-proviral load (PVL) might be predictive factors for differentiating acute and chronic types. Low MST was observed in acute and lymphomatous ATLL, even in the combinational chemo-therapeutic regimens. Therefore, it seems that ATLL treatment should be personalized according to the virus-host interactions on survival signaling pathways, the platelet count and calcium level.