bluuebunny/crossref_metadata_2025_split huggingface dataset:
QSAR and Molecular Docking Studies on a Series of 1-Amino-5H-pyrido [4, 3-b]indol-4-carboxamides Acting as Janus Kinase 2 (JAK2) Inhibitors
Authors: Shaik Basheerulla , Gupta Satya P. , Zafar Tabassum , Anita K. 
Published: March 2020

Background:
The Janus enzyme family is regulated by various cytokines together with
interleukins, interferons, and hormones like glycoprotein, thromboprotein, and hormone. Metamorphosis
and translocations in the Janus Kinase genes leading to constitutively active Janus Kinase
proteins are associated with a variety of hematopoietic malignancies, comprising the myeloproliferative
disorders, acute lymphoblastic leukemia, acute myeloid leukemia (JAK2, JAK1), acute
megakaryoblastic leukemia (JAK2, JAK3). Hence the study of the inhibitors of Janus Kinase is
desired.

Methods:
Research and online content related to 1-amino-5H-pyrido [4,3-b]indol-4-carboxamide
analogues (I) that were synthesized and evaluated for their JAK2 inhibitory activity is reviewed,
and in order to design and develop still better and more effective JAK inhibitors, we have
made Quantitative Structure Activity Relationship (QSAR), docking and ADMET studies on these
compounds

Results:
The best GA-MLR equation based on four descriptors along with statistical parameters is
obtained using QSARINS software. Using the model expressed by this study we predicted some
new compounds of high JAK2 inhibition potency. Each predicted compound has very high potency
with which only a few compounds of existing series can match.

Conclusion:
The QSAR and molecular modelling studies suggested that still better compounds can
be designed if the flexibility of the molecules can be increased for which attempts can be made to
have more saturated atoms in the molecules. Such a compound predicted by us was found to have
interactions with the enzyme JAK2 almost in the same manner as the FDA approved compound,
Momelotinib.
A nemzetközi diplomamobilitás stratégiai irányvonalai – a Magyarországon tanulmányokat folytató külföldi hallgatók motiváció, valamint a külföldi tanulmányokat befolyásoló tényezők vizsgálata
Authors: Bocskei Elvira , Bacs Zoltan , Kovacs Barnabas , Tarnoczi Tibor , Fenyves Veronika 
Published: March 2020

Kutatásunk során a Magyarországon tanulmányokat folytató külföldi hallgatók motivációit vizsgáltuk. Kérdőíves kutatásunk célja az volt, hogy mind a keresleti,mind a kínálati oldalon feltárjuk azokat a lehetőségek, amelyek alapján a hazájukon kívül tanulmányokat folytatni kívánó fiatalok Magyarországot, mint lehetséges célországot jelölik meg. A kutatás első fázisában a befelé irányuló hallgatói mobilitás statisztikai vizsgálatát végeztük el. A magyar felsőoktatásról alkotott kép azért is érdekes, mert ugyan a legtöbb hallgatót küldő országok között ma még a közvetlen szomszédos országokat találjuk (Szlovákiát, Romániát, Szerbiát és Ukrajnát), ugyanakkor Norvégia mellett az ázsiai (Kína, Irán) és afrikai (Nigéria) országok hallgatóinak dinamikus növekedése figyelhető meg (Oktatási Hivatal statisztikai adatbázisa). A kutatás második fázisában került sor a kérdőíves felmérésre, amellyel arra kerestük a választ, hogy:– milyen tényezők játszottak szerepet abban, hogy a külföldi hallgató hazáján kívül folytasson tanulmányokat (mikor döntött a külföldi tanulás mellett, honnan szerezte információit, melyek voltak azok a tényezők, amelyek befolyásolták ország- és intézményválasztását stb.),– mennyiben elégedett a választott képzéssel, az oktatásszervezéssel, továbbá a képzés befejezését követően mik a jövőbeni tervei,– a képzési, megélhetési költségek alakulására vonatkozó milyen előzetes információkkal rendelkezett, melyek voltak a finanszírozás forrásai, hogyan alakultak a megélhetési költségei, illetve megtérültek-e ezek a költségek, milyen volt a szabadidő és a tanulás aránya, valamint a szabadidő eltöltésének lehetőségei,– mennyiben elégedett az intézményi szolgáltatásokkal (technikai felszereltséggel, oktatótermek felszereltségével, könyvtári szolgáltatással, intézményi programokkal).Cikkünkben, a terjedelmi korlátokra való tekintettel, a külföldi tanulmányokat befolyásoló tényezők vizsgálatára térünk ki.
Journal of Economic Literature (JEL) kódok: I2, J1
Munkáltatói kompetenciaelvárások vizsgálata piaci környezetben
Authors: Tothne Teglas Tunde , Hledik Erika 
Published: March 2020

A vállalati körökben készített felmérések, munkaerőpiaci prognózisok arra hívják fel a figyelmet, hogy a munkaerőpiacon megfigyelhető változások a munkavállalás minőségi követelményeit is jelentősen átalakítják. A szakértők ezen kompetenciaelvárások bővülését és átrendeződését prognosztizálják. A munkavállalók ugyanakkor elhelyezkedésük során nagyon eltérő követelményeket tapasztalhatnak. Vannak munkáltatók, akiknek kifejezetten magasak az elvárásaik, de természetesen nem mindenhol érezhetők ezek. Tanulmányunkban a diplomás pályakezdőkkel szembeni kompetenciaelvárások megismerését szolgáló kvalitatív kutatásunk eredményei alapján arra keressük a választ, hogy vajon a hazai vállalatok hogyan reagálnak a változásokra munkavállalóikkal szemben támasztott követelményeik megfogalmazása során. Azt vizsgáljuk a prognózisok tükrében, hogy mely kompetenciák mentén tapasztalható már napjainkban is, hogy új, bővülő tartalommal gondolkodnak a munkáltatók. Munkánkban a kompetenciákat dinamikus változóként kezelve a diplomás pályakezdőkkel szembeni kompetenciaelvárások alakulását a keresleti oldal, azaz a munkáltatók szervezeti működésükhöz szükségek kompetenciaigényei, valamint a kínálati oldal, azaz a pályakezdők felkészültségével kapcsolatos tapasztalataik kölcsönhatásában vizsgáljuk.
Journal of Economic Literature (JEL) kódok: J23, J24, J53
Модификация рельефа n-поверхности AlGaInN-светодиодов изменением состава газовой смеси при реактивном ионном травлении
Authors: Марков Л.К. , Смирнова И.П. , Кукушкин М.В. , Павлюченко А.С. 
Published: March 2020

Abstract The kind of profile produced during the reactive ion etching of AlGaInN light-emitting-diode (LED) heterostructures on the surface that became free after removal of the growth substrate is studied in relation to the composition of the gas mixture used in the etching process. It is shown that using a mixture composed of Cl_2 and Ar, taken in a 3:2 ratio in terms of flow rates, leads to the thinnest profile, whereas a 2 : 1 gas mixture of BCl_3 and Ar provides the largest structural elements. To study the effect of the kind of profile on the quantum efficiency (QE), flip-chip LEDs are fabricated on a silicon substrate. The LEDs are etched in different modes after the growth substrate is removed. Etching in the Cl_2:BCl_3:Ar mixture with a flow ratio of 6:10:11, which leads to intermediate sizes of the etching profile elements, is optimal for obtaining maximum light extraction from a LED chip at a wavelength of 460 nm. The variation of the kind of profile with the gas-mixture composition suggests that the profile parameters can be tuned to the wavelength used. An analysis of how the QE of LED chips depends on the etching duration in the three-component mixture under consideration results in that the optimum etching duration is estimated to be ~30 min. The results of the study can also be of use in the search for conditions minimizing the reflection of incident light by a chip, e.g., for photodetectors.
Cognition in Context: Understanding the Everyday Predictors of Cognitive Performance in a New Era of Measurement
Authors: Weizenbaum Emma , Torous John , Fulford Daniel 
Published: March 2020

BackgroundResearch suggests that variability in attention and working memory scores, as seen across time points, may be a sensitive indicator of impairment compared with a singular score at one point in time. Given that fluctuation in cognitive performance is a meaningful metric of real-world function and trajectory, it is valuable to understand the internal state-based and environmental factors that could be driving these fluctuations in performance.ObjectiveIn this viewpoint, we argue for the use of repeated mobile assessment as a way to better understand how context shapes moment-to-moment cognitive performance. To elucidate potential factors that give rise to intraindividual variability, we highlight existing literature that has linked both internal and external modifying variables to a number of cognitive domains. We identify ways in which these variables could be measured using mobile assessment to capture them in ecologically meaningful settings (ie, in daily life). Finally, we describe a number of studies that have already begun to use mobile assessment to measure changes in real time cognitive performance in people’s daily environments and the ways in which this burgeoning methodology may continue to advance the field.MethodsThis paper describes selected literature on contextual factors that examined how experimentally induced or self-reported contextual variables (ie, affect, motivation, time of day, environmental noise, physical activity, and social activity) related to tests of cognitive performance. We also selected papers that used mobile assessment of cognition; these papers were chosen for their use of high-frequency time-series measurement of cognition using a mobile device.ResultsUpon review of the relevant literature, it is evident that contextual factors have the potential to meaningfully impact cognitive performance when measured in laboratory and daily life environments. Although this research has shed light on the question of what gives rise to real-life variability in cognitive function (eg, affect and activity), many of the studies were limited by traditional methods of data collection (eg, involving retrospective recall). Furthermore, cognition has often been measured in one domain or in one age group, which does not allow us to extrapolate results to other cognitive domains and across the life span. On the basis of the literature reviewed, mobile assessment of cognition shows high levels of feasibility and validity and could be a useful method for capturing individual cognitive variability in real-world contexts via passive and active measures.ConclusionsWe propose that, through the use of mobile assessment, there is an opportunity to combine multiple sources of contextual and cognitive data. These data have the potential to provide individualized digital signatures that could improve diagnostic precision and lead to meaningful clinical outcomes in a wide range of psychiatric and neurological disorders.
Risks and Benefits of Web-Based Patient Narratives: Systematic Review
Authors: Drewniak Daniel , Glässel Andrea , Hodel Martina , Biller-Andorno Nikola 
Published: March 2020

Background
Patient narratives are illustrative, individual accounts of patients’ experiences with certain health conditions. Web-based patient narratives have become widely available on the internet and in social media, as part of electronically available patient decision aids or Web-based databases. In recent years, the role of patient narratives as a source of information, insight, and support for both health care users and providers has increasingly been emphasized. Although the potential impact of patient stories has high immediate plausibility, it is of interest to know if this impact can be captured in quantitative studies.

Objective
This review aimed to evaluate whether research-generated Web-based patient narratives have quantifiable risks or benefits for (potential) patients, relatives, or health care professionals.

Methods
We searched the following databases from August 2017 to March 2019: Medical Literature Analysis and Retrieval System Online, PsycInfo, Sociological Abstracts, Web of Science, and EMBASE. Titles and abstracts of the retrieved studies were reviewed and assessed for the inclusion and exclusion criteria. Papers were included if they studied the following: (1) (potential) patients, relatives, or health care professionals; (2) the effects of Web-based patient narratives that were generated scientifically (eg, through qualitative research methods); and (3) were quantitative studies. Furthermore, 2 authors independently performed an assessment of the quality of the included studies using a validated checklist.

Results
Of 4226 documents, 17 studies met the inclusion criteria. The studies investigated 10 different sources of Web-based patient narratives. Sample sizes ranged from 23 to 2458. The mean score of the quality assessment was 82.6 (range 61-100). Effects regarding five different purposes were identified as follows: provide information, engage, model behavior, persuade, and comfort. We found positive effects in every category and negative effects in one category (persuade). Several of the reported effects are rather small or were identified under specific experimental conditions.

Conclusions
Patient narratives seem to be a promising means to support users in improving their understanding of certain health conditions and possibly to provide emotional support and have an impact on behavioral changes. There is limited evidence for beneficial effects on some outcomes. However, narratives are characterized by considerable heterogeneity and the investigated outcomes are hardly comparable with each other, which makes the overall judgment difficult. As there are numerous possible measures and purposes of narratives, quantifying the impact of Web-based patient narratives remains a challenge. Future research is needed to define the optimal standards for quantitative approaches to narrative-based interventions.
Analisis Efektivitas Biaya Terapi Antihipertensi Kombinasi Tetap Di Satu Rumah Sakit Jakarta Selatan
Authors: Rahayu Ani , Afdhal Ahmad Fuad , Hasan Delina , Suwarna Feriadi , Meila Okpri 
Published: March 2020

The majority of alternative antihypertensive therapies require pharmacoeconomic studies, particularly Cost Effectiveness Analysis, which is useful in balancing patients’ expenditure by determining alternative treatments that represented the most plausible health outcomes with a more reasonable budget. The objective of this study was to compare the cost effectiveness using antihypertensive fixed dose combinations (FDC) of Valsartan-Amlodipine + Furosemide and FDC of Valsartan-HCT + Amlodipin. This research applied the descriptive analytical cross-sectional method and conducted data collection retrospectively from the medical record of hypertensive patients. Meanwhile, the medication cost breakdown was obtained from Outpatient Financial Department of a Type B Hospital in south Jakarta for the period of January - June 2018. Total sample were 74 patients, consisted of 37 patients who used FDC of Valsartan-Amlodipin + Furosemide, and 37 patients who used FDC of Valsartan-HCT + Amlodipin. The parameters of this research were direct medication cost (consisted of examination cost, laboratory cost and medicines cost), indirect medication cost (consisted accommodation cost and lost productivity cost), while the effectiveness used the MAP average (Mean Arterial Pressure). The result of this research showed that the biggest medication effectiveness to lower the blood pressure is FDC of Valsartan-Amlodipin + Furosemide, with 32 patients had the average MAP 101,29 mmHg, while the FDC of Valsartan-HCT + Amlodipin with 29 patients had the average MAP 103,59 mmHg. The cost effectiveness based on ACER value of FDC of Valsartan –HCT + Amlodipin and FDC Valsartan-HCT + Amlodipin sequentially is Rp 3.922.040/MAP and Rp 4.458.034/MAP. In conclusion, the FDC of Valsartan-Amlodipin + Furosemide was more cost-effective.
Psikoedukasi Kebersyukuran Kepada Tuhan
Authors: Susanti Rizky , Dewi Yolanda Kartika , Ayuwarningsih Rani 
Published: March 2020

Masa remaja adalah masa peralihan dari anak-anak ke dewasa. Di masa remaja banyak sekali terjadi perubahan pada diri anak. Mulai dari fisik, emosi dan kognitif. Perubahan-perubahan itu memengaruhi perilaku remaja itu sendiri. Oleh karena itu, di masa remaja sering kali menjadi masa-masa yang rawan masalah. Salah satu penyelesaian yaitu dengan adanya rasa syukur kepada Tuhan. Tujuan kegiatan pengabdian masyarakat yaitu untuk memberikan psikoedukasi tentang kebersyukuran kepada Tuhan. Mitra kegiatan yaitu panti asuhan putri aisiyah Malang. Hasil dari pengabdian ini menggambarkan bahwa secara keseluruhan remaja panti asuhan memiliki kebersyukuran yang sedang dengan aspek yang paling dominan yaitu pada aspek grateful, sedangkan skor terendah pada aspek thankful.
Training Manajemen Diri Pada Siswa Akselerasi MAN 1 Malang
Authors: Djudiyah Djudiyah , Haq Ihsanul , Rahmah Makkiyatur 
Published: March 2020

Masa remaja adalah masa peralihan dari anak-anak ke dewasa. Di masa remaja banyak sekali terjadi perubahan pada diri anak. Mulai dari fisik, emosi, dan kognitif. Perubahan-perubahan itu mempengaruhi hakekat relasi orang tua dan remaja itu sendiri. Oleh karena itu, di masa remaja seringkali menjadi masa-masa yang kritis. Karena pada tahapan inilah seseorang mencari identitas dirinya. Fakta-fakta tersebut juga terdapat pada siswa akselerasi di MAN I Malang, beberapa anak mengalami kesulitan dalam mengelola dirinya sehingga membuat belajarnya tidak maksimal pada hal tuntutan akademik sangat tinggi dengan adanya batasan masa studi selama dua tahun. Selain itu, banyak keluhan yang disampaikan oleh para guru khususnya guru Bimbingan Konseling bahwa terdapat beberapa masalah yang perlu mendapat perhatian khusus, yaitu terkait dengan pengembangan soft skill sehingga perlu kiranya dilakukan pendampingan khusus dalam rangka memberikan fasilitas untuk pengembangan diri siswa akselerasi. Hasil dari pengabdian ini menggambarkan bahwa siswa akselerasi sangat tertarik dengan kegiatan ini dan melalui kegiatan ini siswa akselerasi dapat mengetahui potensi psikologisnya sehingga membantu siswa akselerasi dapat lebih mudah untuk mengoptimalkan potensi-potensinya.
Is there an agreement between self-reported medical diagnosis in the CARTaGENE cohort and the Québec administrative health databases?
Authors: Payette Yves , Moura Cristiano Soares de , Boileau Catherine , Bernatsky Sasha , Noisel Nolwenn 
Published: March 2020

BackgroundPopulation health studies often use existing databases that are not necessarily constituted for research purposes. The question arises as to whether different data sources such as in administrative health data (AHD) and self-report questionnaires are equivalent and lead to similar information.
ObjectivesThe main objective of this study was to assess the level of agreement between self-reported medical conditions and medical diagnosis captured in AHD. A secondary objective was to identify predictors of agreement among medical conditions between the two data sources. Therefore, the purposes of the study were to explore the extent to which these two methods of commonly used public health data collection provide concordant records and identify the main predictors of statistical variations.
MethodsData was extracted from CARTaGENE, a population-based cohort study in Québec, Canada, which was linked to the provincial health insurance records of the same individuals, namely the MED-ÉCHO database from the Régie de l’assurance maladie du Québec (RAMQ) and the fee-for-service billing records provided by the physician, for the time period 1998-2012. Agreement statistics (kappa coefficient) along with sensitivity, specificity and predictive positive value were calculated for 19 chronic conditions and 12 types of cancers. Logistic regressions were used to identify predictors of concordance between self-report and AHD from significant covariates (sex, age groups, education, region, income, heavy utilization of health care system and Charlson comorbidity index).
ResultsAgreement between self-reported data and AHD across diseases ranged from kappa of 0.09 for chronic renal failure to 0.86 for type 2 diabetes. Sensitivity of self-reported data was higher than 50% for 14 out of the 31 medical conditions studied, especially for myocardial infarction (88.62%), breast cancer (86.28%), and diabetes (85.06%). Specificity was generally high with a minimum value of 89.70%. Lower concordance between data sources was observed for higher frequency of health care utilization and higher comorbidity scores.
ConclusionOverall, there was moderate agreement between the two data sources but important variations were found depending on the type of disease. This suggests that CARTaGENE’s participants were generally able to correctly identify the kind of diseases they suffer from, with some exceptions. These results may help researchers choose adequate data sources according to specific study objectives. These results also suggest that Québec’s AHD seem to underestimate the prevalence of some chronic conditions, which might result in inaccurate estimates of morbidity with consequences for public health surveillance.
Apropiación y control de recursos en la expansión urbana. La periferia metropolitana como espacio de disputa entre actores sociales
Authors: Mejía Hernández Ismael , Pedrotti Carolina Inés 
Published: March 2020

En este artículo se presenta a los pueblos originarios y sus lógicas de acción como parte del conjunto de actores que configuran e influyen en el proceso de urbanización en la periferia metropolitana del Valle de México. Ellos son quienes han poblado tradicionalmente estos espacios y han utilizado los recursos básicos del territorio para su asentamiento, empleo y subsistencia. Lo anterior les otorgó históricamente cierto margen de autoridad y control sobre dichos recursos, situación que ha ido cambiando e incluso perdiéndose con el tiempo, dados los procesos de poblamiento y transformación de su entorno inmediato, y la consecuente intervención de otros actores, con quienes hoy disputan estos recursos, especialmente el suelo urbanizable y el agua, elementos indispensables para la urbanización.
The role of Open-book Management in Achieving Organizational Agility “Research based on PhD. Thesis”
Authors: Hussein Al-Taii Mohammed A. , Ismael Hadi Kh. , Khudhur Shihab A. 
Published: March 2020

The study aims at acknowledging the impact of Open-book management on the types of organizational agility (sensing agility, decision-making agility, and acting agility) in the private universities / Kurdistan Region - Iraq. The study has used the analytical descriptive methodology, through using questionnaire to collect information from the members of the university councils in (11) private university in Kurdistan Region - Iraq. The sample of the study includes (91) members of the university councils. The statistical program (SPSS. V. 21) has been used to analysis the information collected and to get the results of the hypotheses testing.
The main findings of the study were that the surveyed universities are practicing both of open-book management and organizational agility at high levels. The study also indicates that open-book management has a significant impact on organizational agility at the surveyed universities. A number of suggestions were presented focusing on that the private universities need to pay more attention to practice open-book management as it has a positive significant impact on achieving organizational agility.
Quality Human Resources in Lam Dong and the Issues Posed
Authors: Thuy Dung Vu Thi 
Published: March 2020

Lam Dong is evaluated as a potential province in socio-economic development in the Central Highlands for many years. The development speed of Lam Dong contributes significantly to the development speed of the Central Highlands and the whole country. Contributing to that growth, we must mention Lam Dong's strategy of investing in the quality of human resources. More specifically, the input of high quality human resources based on local strengths is the fast, strong and sustainable direction of Lam Dong in recent years.
This paper focuses on analyzing and evaluating the quality of human resources in Lam Dong in three aspects considered to be "three specialties" of Lam Dong which are human resources in the field of high-tech agriculture and human resources. in the field of tourism services and human resources for ethnic minorities. Since then, the article proposes solutions directions in the strategy for developing human resources, especially high-quality human resources of Lam Dong in the future.