bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors of Neovascular Glaucoma After 25-gauge Vitrectomy for Proliferative Diabetic Retinopathy with Vitreous Hemorrhage: A Retrospective Multicenter Study
Authors: Takayama Kei , Someya Hideaki , Yokoyama Hiroshi , Takamura Yoshihiro , Morioka Masakazu , Sameshima Seiji , Ueda Tetsuo , Kitano Shigehiko , Tashiro Maki , Sugimoto Masahiko , Kondo Mineo , Sakamoto Taiji , Takeuchi Masaru 
Published: October 2019

AbstractNeovascular glaucoma (NVG) is a terminal severe complication in eyes with proliferative diabetic retinopathy (PDR), and PDR eyes with vitreous hemorrhage (VH) which undergo vitrectomy may have higher risk of postoperative NVG. The incidence and the prognostic factor of postoperative NVG after 25-gauge vitrectomy with advanced surgical options remain unclear. We retrospectively reviewed medical records of 268 eyes of 268 consecutive PDR patients with VH who underwent 25-gauge vitrectomy and 12 months follow-up at seven centers. Preoperative ocular factors (visual acuity, tractional retinal detachment, panretinal photocoagulation [PRP]), demographics and clinical factors (sex, age, diabetic duration, HbA1c, hypertension, anticoagulant medication, and kidney function), surgical procedures, and postoperative complications were compared between patients who developed postoperative NVG (9.3%) and those who did not. NVG eyes was significantly younger (P = 0.026), had shorter diabetic duration (P = 0.022), higher HbA1c (P = 0.028), absence of PRP (P = 0.039) and higher frequency of postoperative VH (P = 0.0075) than non-NVG eyes. Logistic regression analysis identified postoperative VH (P = 0.014), shorter diabetic duration (P = 0.029), and no PRP (P = 0.028) as prognostic factors for postoperative NVG. This multicenter study indicates that younger age, uncontrolled diabetes, no PRP, and postoperative VH are risk factors of post-vitrectomy NVG.
Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide
Authors: Huang Phoebe A. , Beedie Shaunna L. , Chau Cindy H. , Venzon David J. , Gere Sheryl , Kazandjian Dickran , Korde Neha , Mailankody Sham , Landgren Ola , Figg William D. 
Published: October 2019

AbstractCarfilzomib-lenalidomide-dexamethasone (KRd) therapy has yielded promising results in patients with newly diagnosed multiple myeloma (NDMM). Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. In this study, we assessed the correlation of five single nucleotide variants (SNVs) in the CRBN gene with clinical response and outcomes in patients with NDMM administered KRd therapy with lenalidomide maintenance, achieving favorable trial endpoints in a prospective Phase II study (NCT01402284). Of the observed SNVs, no associations with KRd therapy response were found in this patient cohort, although strong trends in hypoalbuminemia grade and hyperbilirubinemia grade emerged across the CRBN rs1672753 genotype (P = 0.0008) and the rs1714327 genotype (P = 0.0010), respectively. Our results do not provide conclusive support for the predictive utility of CRBN gene polymorphisms as potential biomarkers of clinical response to lenalidomide-based therapy in our patient population. However, these findings remain to be validated in prospective studies using larger patient populations.
Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder
Authors: Kunii Yasuto , Hino Mizuki , Matsumoto Junya , Nagaoka Atsuko , Nawa Hiroyuki , Kakita Akiyoshi , Akatsu Hiroyasu , Hashizume Yoshio , Yabe Hirooki 
Published: October 2019

AbstractDopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) integrates dopaminergic signaling into that of several other neurotransmitters. Calcineurin (CaN), located downstream of dopaminergic pathways, inactivates DARPP-32 by dephosphorylation. Despite several studies have examined their expression levels of gene and protein in postmortem patients’ brains, they rendered inconsistent results. In this study, protein expression levels of DARPP-32 and CaN were measured by enzyme-linked immunosorbent assay (ELISA) in the prefrontal cortex (PFC), and nucleus accumbens (NAc) of 49 postmortem samples from subjects with schizophrenia, bipolar disorder, and normal controls. We also examined the association between this expression and genetic variants of 8 dopaminergic system-associated molecules for 55 SNPs in the same postmortem samples. In the PFC of patients with schizophrenia, levels of DARPP-32 were significantly decreased, while those of CaN tended to increase. In the NAc, both of DARPP-32 and CaN showed no significant alternations in patients with schizophrenia or bipolar disorder. Further analysis of the correlation of DARPP-32 and CaN expressions, we found that positive correlations in controls and schizophrenia in PFC, and schizophrenia in NAc. In PFC, the expression ratio of DARPP-32/CaN were significantly lower in schizophrenia than controls. We also found that several of the aforementioned SNPs may predict protein expression, one of which was confirmed in a second independent sample set. This differential expression of DARPP-32 and CaN may reflect potential molecular mechanisms underlying the pathogenesis of schizophrenia and bipolar disorder, or differences between these two major psychiatric diseases.
Effects of cycling on lithium-ion battery hysteresis and overvoltage
Authors: Ovejas V. J. , Cuadras A. 
Published: October 2019

AbstractCurrently, lithium-ion batteries are widely used as energy storage systems for mobile applications. However, a better understanding of their nature is still required to improve battery management systems (BMS). Overvoltages and open-circuit voltage (OCV) hysteresis provide valuable information regarding battery performance, but estimations of these parameters are generally inaccurate, leading to errors in BMS. Studies on hysteresis are commonly avoided because the hysteresis depends on the state of charge and degradation level and requires time-consuming measurements. We have investigated hysteresis and overvoltages in Li(NiMnCo)O2/graphite and LiFePO4/graphite commercial cells. Here we report a direct relationship between an increase in OCV hysteresis and an increase in charge overvoltage when the cells are degraded by cycling. We find that the hysteresis is related to diffusion and increases with the formation of pure phases, being primarily related to the graphite electrode. These findings indicate that the graphite electrode is a determining factor for cell efficiency.
Direct detection of brown adipose tissue thermogenesis in UCP1−/− mice by hyperpolarized 129Xe MR thermometry
Authors: Antonacci Michael A. , McHugh Christian , Kelley Michele , McCallister Andrew , Degan Simone , Branca Rosa T. 
Published: October 2019

AbstractBrown adipose tissue (BAT) is a type of fat specialized in non-shivering thermogenesis. While non-shivering thermogenesis is mediated primarily by uncoupling protein 1 (UCP1), the development of the UCP1 knockout mouse has enabled the study of possible UCP1-independent non-shivering thermogenic mechanisms, whose existence has been shown so far only indirectly in white adipose tissue and still continues to be a matter of debate in BAT. In this study, by using magnetic resonance thermometry with hyperpolarized xenon, we produce the first direct evidence of UCP1-independent BAT thermogenesis in knockout mice. We found that, following adrenergic stimulation, the BAT temperature of knockout mice increases more and faster than rectal temperature. While with this study we cannot exclude or separate the physiological effect of norepinephrine on core body temperature, the fast increase of iBAT temperature seems to suggest the existence of a possible UCP1-independent thermogenic mechanism responsible for this temperature increase.
Bacterial, archaeal and micro-eukaryotic communities characterize a disease-suppressive or conducive soil and a cultivar resistant or susceptible to common scab
Authors: Kopecky Jan , Samkova Zuzana , Sarikhani Ensyeh , Kyselková Martina , Omelka Marek , Kristufek Vaclav , Divis Jiri , Grundmann Geneviève G. , Moënne-Loccoz Yvan , Sagova-Mareckova Marketa 
Published: October 2019

AbstractControl of common scab disease can be reached by resistant cultivars or suppressive soils. Both mechanisms are likely to translate into particular potato microbiome profiles, but the relative importance of each is not known. Here, microbiomes of bulk and tuberosphere soil and of potato periderm were studied in one resistant and one susceptible cultivar grown in a conducive and a suppressive field. Disease severity was suppressed similarly by both means yet, the copy numbers of txtB gene (coding for a pathogenicity determinant) were similar in both soils but higher in periderms of the susceptible cultivar from conducive soil. Illumina sequencing of 16S rRNA genes for bacteria (completed by 16S rRNA microarray approach) and archaea, and of 18S rRNA genes for micro-eukarytes showed that in bacteria, the more important was the effect of cultivar and diversity decreased from resistant cultivar to bulk soil to susceptible cultivar. The major changes occurred in proportions of Actinobacteria, Chloroflexi, and Proteobacteria. In archaea and micro-eukaryotes, differences were primarily due to the suppressive and conducive soil. The effect of soil suppressiveness × cultivar resistance depended on the microbial community considered, but differed also with respect to soil and plant nutrient contents particularly in N, S and Fe.
Development and Refinement of Patient-Reported Outcome Measures for Hearing: A Brief Introduction to Nonparametric Item Response Theory
Authors: Cassarly Christy , Matthews Lois J. , Simpson Annie N. , Dubno Judy R. 
Published: October 2019

Purpose
The purpose of this report was to demonstrate the value of incorporating nonparametric item response theory in the development and refinement of patient- reported outcome measures for hearing.

Conclusions
Nonparametric item response theory can be useful in the development and refinement of patient-reported outcome measures for hearing. These methods are particularly useful as an alternative to exploratory factor analysis to determine the number of underlying abilities or traits represented by a scale when the items have ordered-categorical responses.
The Effort Required to Comprehend a Short Documentary in Noise: A Comparison of Younger and Older Francophones
Authors: Tangkhpanya Fatima , Le Carrour Morgane , Doucet Félicia , Gagné Jean-Pierre 
Published: October 2019

Speech processing is more effortful under difficult listening conditions. Using a dual-task paradigm, it has been shown that older adults deploy more listening effort than younger adults when performing a speech recognition task in noise.

Purpose
The primary purpose of this study was to investigate whether a dual-task paradigm could be used to investigate differences in listening effort for an audiovisual speech comprehension task. If so, it was predicted that older adults would expend more listening effort than younger adults.

Method
Three groups of participants took part in the investigation: (a) young normal-hearing adults, (b) young normal-hearing adults listening to the speech material low-pass filtered above 3 kHz, and (c) older adults with age-related normal hearing sensitivity or better. A dual-task paradigm was used to measure listening effort. The primary task consisted of comprehending a short documentary presented at 63 dBA in a background noise that consisted of a 4-talker speech babble presented at 69 dBA. The participants had to answer a set of 15 questions related to the content of the documentary. The secondary task was a tactile detection task presented at a random time interval, over a 12-min period (approximately 8 stimuli/min). Each task was performed separately and concurrently.

Results
The younger participants who performed the listening task under the low-pass filtered condition displayed significantly more listening effort than the 2 other groups of participants.

Conclusion
First, the study confirmed that the dual-task paradigm used in this study was sufficiently sensitive to reveal significant differences in listening effort for a speech comprehension task across 3 groups of participants. Contrary to our prediction, it was the group of young normal-hearing participants who listened to the documentaries under the low-pass filtered condition that displayed significantly more listening effort than the other 2 groups of listeners.
Lexical-Level Predictors of Reading Comprehension in Third Grade: Is Spelling a Unique Contributor?
Authors: Murphy Kimberly A. , Justice Laura M. 
Published: October 2019

Purpose
Considerable research effort has focused on understanding reading comprehension and reading comprehension difficulties. The purpose of this correlational study was to add to the small but growing body of literature on the role that spelling may play in reading comprehension, by investigating the full range of lexical-level literacy skills and whether spelling makes a unique contribution. This study also explored whether these relations vary with the spelling scoring metric.

Method
Data were collected from 63 children attending Grade 3 in a Midwestern state. In addition to measuring reading comprehension, word recognition, and vocabulary, 4 spelling scoring metrics were examined: the number of words spelled correctly, the number of correct letter sequences (CLS), and Spelling Sensitivity Scores for elements and for words.

Results
All spelling metrics were significantly correlated with reading comprehension. Results of hierarchical regressions showed that spelling was a significant, unique predictor of reading comprehension when the CLS metric was used. The scoring metrics were differentially related to reading comprehension. Metrics that gave credit based on orthographic precision only (number of words spelled correctly and CLS) were more highly related to reading comprehension than metrics that scored not only on orthographic accuracy but also on phonological and morphological accuracy (Spelling Sensitivity Scores for elements and for words).

Conclusion
These results indicate that spelling is related to reading comprehension and have theoretical and clinical implications for the use of spelling assessment.

Supplemental Material

https://doi.org/10.23641/asha.9947216
Effects of Transcranial Direct Current Stimulation on Apraxia of Speech and Cortical Activation in Patients With Stroke: A Randomized Sham-Controlled Study
Authors: Wang Jie , Wu Dongyu , Cheng Yinan , Song Weiqun , Yuan Ying , Zhang Xu , Zhang Dahua , Zhang Tiantian , Wang Zhuo , Tang Jingwen , Yin Ling 
Published: October 2019

Purpose
The study aims to investigate, using anodal transcranial direct current stimulation (A-tDCS), over which site, the left lip region of primary motor cortex (M1) or the Broca's area, there would be better recovery from apraxia of speech (AoS) in patients with poststroke aphasia and to examine for altered activation in speech-related areas after tDCS with nonlinear electroencephalography (EEG).

Method
Fifty-two patients with AoS were randomized into A-tDCS over the left M1 (A-tDCS-M1), Broca's area, and sham tDCS groups who underwent 10 sessions of tDCS and speech treatment for 5 days. The EEG nonlinear index of approximate entropy was calculated for 6 subjects in each group before and after treatment.

Results

After treatment, the change in speech-language performance improved more significantly in the A-tDCS-M1 group than the other 2 groups (
p
< .05). EEG approximate entropy indicated that both A-tDCS groups could activate the stimulated sites; the improvement in the A-tDCS-M1 group was correlated with high activation in the dorsal lateral prefrontal cortex and Broca's areas of the left hemisphere in addition to the stimulated site.

Conclusion
A-tDCS over the left M1 can improve the speech function in patients with poststroke aphasia and severe AoS and excite and recruit more areas in the motor speech network.
Background bit‐weight calibration in pipelined successive approximation register ADC
Authors: Shen Changsheng 
Published: October 2019

A background bit‐weight calibration in pipelined successive approximation register ADC is proposed. By exploiting the conversion results of the first stage to determine the injection of the dithered signal and introducing two extra capacitors into the first stage to reduce the range of first‐stage residue, a robust and totally background calibration is implemented. According to the simulation, the signal‐to‐noise and distortion ratio and spurious free dynamic range are improved from 66.3 to 73.3 dB and 78.4 to 85.1 dB, respectively, after calibration.
Miniaturised LTCC diplexer with low insertion loss for LTE application
Authors: Kewei Qian 
Published: October 2019

A novel multilayer diplexer with low insertion loss and high selectivity for long‐term evolution (LTE) application is proposed through the combination of two quasi‐lumped element filters. Based on the equivalent circuit of the diplexer, the locations of the transmission zeros can be adjusted separately by changing the component value of each channel, thus high isolation level and wide stopband can be achieved simultaneously. Furthermore, the diplexer has an extremely compact size of 1.6 mm × 0.8 mm × 0.5 mm by using low temperature co‐fired ceramic (LTCC) multilayer technology.
Objets Connectés : Mise en oeuvre d’un challenge intitulé « Industrie du futur, c’est maintenant ! » dans le cadre d’un enseignement pour des élèves ingénieurs
Authors: Vrignat Pascal , Delouche David , Avila Manuel , Begot Stéphane , Bardet Christophe , Duculty Florent , Kratz Frédéric 
Published: October 2019

Parmi les nombreuses stratégies pédagogiques permettant d’améliorer la motivation, le savoir-être et le savoir-faire des élèves ou des étudiants, la pédagogie par projet est souvent citée comme exemple. C’est dans ce contexte, qu’un challenge intitulé « L’industrie du futur, c’est maintenant ! » a été activé en 2018 pour des élèves ingénieurs de spécialités mécatronique et robotique. Sept équipes tirées au sort et constituées d’élèves en 5ème année à HEI campus Centre ont donc participé à ce challenge. Les enjeux techniques à franchir étaient vastes car ils devaient répondre à certains besoins et services consacrés aux enjeux liés à l’industrie digitale ou l’industrie 4.0. Un système de production de jetons en polymère pour serrure de caddy et connecté en réseau a servi de support. Cet article détaille la stratégie pédagogique qui a été adoptée, le cahier des charges technique ainsi que la planification à respecter et certains résultats significatifs. Un outil de mesures concernant l’efficience de la méthode a également été mis en place. Les résultats ainsi obtenus nous ont permis d’affiner notre retour sur expérience concernant le challenge.
Contact arc time – important parameter of DC high-speed circuit-breakers
Authors: Rojek Artur , Skrzyniarz Marek 
Published: October 2019

The parameters of DC high-speed circuit-breakers (HSCB) and test methods are specified in the standards. These standards define requirements of the circuit breakers opening time and the total breaking time. During the direct current (DC) breaking after opening the contacts, the arc ignites, the voltage of which is so low that it does not limit the switched off current. The time in which this phenomenon occurs is defined as the contact arc time.The contact arc time has a significant influence on the breaking process. It can take up to over 40% of arcing time. Therefore, tests were carried out, which were to answer the questions about what and to a what extent affects the contact arc time.Since the standards for high-speed circuit-breakers do not refer to the contact arc time, definitions of this parameter are proposed in the article. Using this definition numerous tests of various factors have been carried out on contact arc time.The conducted research shows that shortening the DC breaking time through high-speed breakers is possible by limiting the contact arc time, which can be obtained by modifying the circuit breaker’s construction.
Konsensus der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße (DAM) für Mindeststandards mikrochirurgischer Trainings- und Übungskurse zur Vergabe eines Qualitätssiegels
Authors: Hirche Christoph , Megerle Kai , Heitmann Christoph , Rois Johannes , Russe Friedrich , Froschauer Stefan Mathias , Lehnhardt Marcus , Kneser Ulrich , Schaefer Dirk J. , Kremer Thomas 
Published: October 2019

ZusammenfassungMikrochirurgische Trainings- und Übungskurse sind ein elementarer Bestandteil der chirurgischen Aus- und Weiterbildung. Durch die Veränderungen des chirurgischen Alltags hat das Kompetenzen- und Fertigkeitentraining außerhalb des Operationssaals einen zunehmend bedeutsamen Stellenwert. Mehrtägig zusammenhängende, praktische Übungen mit verschiedenen Modellen mit steigendem Schwierigkeitsgrad verwenden artifizielle, avitale und vitale mikrochirurgische Modelle. Die Evaluation der Fertigkeiten erfolgt im Hinblick auf feinmotorische Fähigkeiten sowie Orientierung im Raum und zielgerichtete, tremorarme Bewegungsabläufe sowie bimanuelle Manipulationsübungen mittels „global rating scales“. Bei zahlreichen Kursangeboten im deutschsprachigen Raum existieren jedoch keine einheitlichen und transparenten Inhalte und Bewertungsmaßstäbe, um die Qualität der Kurse widerzuspiegeln. Im Rahmen eines Konsensustreffens wurden Mindestanforderungen für die Inhalte von mikrochirurgischen Trainings- und Übungskursen im Rahmen der ärztliche Weiterbildung definiert und als deutschsprachiger Konsens verfasst, um ein DAM-Qualitätssiegel zu vergeben. Als Parameter zählen hierzu die Definition von abgestuften Kurszielen, Vorhandensein eines Kursskriptes, Stundenzahl des Kurses, verwendete Modelle, praktische Übungszeit am Mikroskop, Betreuer zu Teilnehmerverhältnis, Anastomosen- bzw. Koaptationsarten (Arterie, Vene, Nerv, Lymphgefäß), Anwendung einer Global Rating Scale, Lernzielüberprüfung (Note/bestanden- nicht bestanden), Teilnehmerzertifikat und Kursevaluation. Mit dem Ziel, den verfügbaren Kursen/Kurskonzepten zur Wahrung bzw. Verbesserung der Qualität der Aus- und Weiterbildung gerecht zu werden, wurde die Zuordnung eines „Basic“ und eines „Advanced“ Qualitätssiegels definiert. Die stetige Weiterentwicklung der Kurse ist notwendig, um nachhaltig Kompetenzen und Fertigkeiten zu erhalten. In Zukunft können auch validierte mikrochirurgische Simulatoren in Trainings- und Übungskurse integriert werden, was zu einer Reduktion der Verwendung von Nagern führen und der ethischen Verantwortung Rechnung tragen kann. Die Einführung von Qualitätssiegeln für mikrochirurgische Übungskurse soll die Transparenz und Verbindlichkeit für Teilnehmer stärken und Kursanbietern mit entsprechend nachgewiesenen Inhalten Unterstützung durch die DAM gewähren.