bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry 4.0: a review and analysis of contingency and performance effects
Authors: Szász Levente , Demeter Krisztina , Rácz Béla-Gergely , Losonci Dávid 
Published: May 2020

PurposeThe purpose of this paper is to review the literature and offer a more generalizable empirical investigation on the performance impact of implementing Industry 4.0, and the way important contingency factors (plant size, multinational status, country context) affect implementation efforts.Design/methodology/approachFollowing a systematic literature review, the empirical research is based on a large-scale survey of 705 manufacturing plants from 22 countries. Structural equation modeling is employed to discover the relationships between the main constructs of interest, complemented with subgroup analyses to offer a more detailed understanding of the main effects.FindingsWe provide evidence that technologies enabling Industry 4.0 have a positive impact on operational performance, including cost, quality, delivery and flexibility performance. Results of the analyses further indicate that (1) larger firms invest more in implementing Industry 4.0 technologies, (2) manufacturing firms in less competitive countries, especially in the South-East Asian region invest significantly more effort than competitive countries, while (3) multinational companies have no advantage over local firms.Research limitations/implicationsThe survey data employed in this study refers to the early years of companies embracing Industry 4.0 solutions, and thus does not contain the most recent advances in manufacturing technologies.Originality/valueThe paper represents one of the first studies in the literature to assess on a large-scale survey the performance impact of Industry 4.0 technologies, as well as the main contingency factors affecting the implementation of these technologies.
The circle of vulnerability and the myth of choice
Authors: Small Felicity , Mehmet Michael , Kleinschafer Jodie 
Published: May 2020

Purpose
People living with a disability (PWD) are often a marginalized vulnerable group who are economically and socially disadvantaged. This paper aims to explore the implementation of new social and financial policy reforms aimed at transforming the disability sector. Using the capabilities approach, the authors explore the experience of carers and evaluate how this sector may have become more exposed and vulnerable as a consequence of the new policy.

Design/methodology/approach
This is a qualitative study with two rounds of semi-structured interviews; at initial-phase (n = 18) and post-phase (n = 14). Thematic analysis was applied to the capabilities and vulnerabilities framework to categorize and analyze the interview data.

Findings
The findings show that there are many ways PWD and carers are experiencing increased levels of vulnerability because of their capabilities. There is evidence of increased vulnerability in the intersections between PWD/carers’ inherent nature, the disruption to vital social relationships and conflicting values and interests of stakeholders and the complexity of situational policy changes.

Practical implications
Practical implications developed from the findings include identifying ways the government can improve its social marketing communication strategies. They also highlight the importance of building effective social support networks and provide guidelines for measuring capacity building to address some of the underlying factors leading to vulnerability.

Originality/value
This paper introduces into social marketing, the three-factor vulnerability framework, which conceptualizes the nature of vulnerability, and examines and evaluates the intersections of these factors in relation to the capabilities approach.
Public libraries in crisis time: empirigraphy of Iranian public libraries in the 2019 Iran massive flood
Authors: Pazooki Fatemeh , Saboori Fahimeh 
Published: May 2020

PurposeOne of the largest floods in Iran happened in Nowruz in 2019, during which torrents of rain, flooding of rivers, landslides and the destruction of dams caused floods and led to financial losses and loss of life in 25 provinces of Iran. During and after the flood, 39 public libraries were closed, three libraries were evacuated and one was completely destroyed.Design/methodology/approachDespite the damage that occurred in the libraries, the preventive measures had been taken by many of them to reduce the whole damage. In addition, after the flood, responsible organizations including Iran Public Libraries Institution, the Institute for the Intellectual Development of Children and Young Adults and the Cultural and Art Organization of Municipality and the Mosques and Cultural Center, as well as other relief and social teams, and even people performed activities to reduce the negative impacts caused by the flood.FindingsThis article reviews these activities and their effectiveness. In the end, “the development of a plan for public libraries in natural and social crises” is proposed and the reasons for its necessity are discussed.Originality/valueThis article reviews these activities and their effectiveness. In the end, “the development of a plan for public libraries in natural and social crises” is proposed and the reasons for its necessity are discussed.
Incidence and characteristics of pregnancy‐related death across ten low‐ and middle‐income geographical regions: secondary analysis of a cluster randomised controlled trial
Authors: Vousden N , Holmes E , Seed PT , Gidiri MF , Goudar S , Sandall J , Chinkoyo S , Kumsa LY , Brown A , Charantimath U , Bellad M , Nakimuli A , Vwalika B , Chappell LC , Shennan AH ,   the CRADLE Trial Collaborative Group
Published: May 2020

ObjectiveThe aim of this article is to describe the incidence and characteristics of pregnancy‐related death in low‐ and middle‐resource settings, in relation to the availability of key obstetric resources.DesignThis is a secondary analysis of a stepped‐wedge cluster randomised controlled trial.SettingThis trial was undertaken at ten sites across eight low‐ and middle‐income countries in sub‐Saharan Africa, India and Haiti.PopulationInstitutional‐level consent was obtained and all women presenting for maternity care were eligible for inclusion.MethodsPregnancy‐related deaths were collected prospectively from routine data sources and active case searching.Main outcome measuresPregnancy‐related death, place, timing and age of maternal death, and neonatal outcomes in women with this outcome.ResultsOver 20 months, in 536 233 deliveries there were 998 maternal deaths (18.6/10 000, range 28/10 000–630/10 000). The leading causes of death were obstetric haemorrhage (36.0%, n = 359), hypertensive disorders of pregnancy (20.6%, n = 206), sepsis (14.1%, n = 141) and other (26.5%, n = 264). Approximately a quarter of deaths occurred prior to delivery (28.4%, n = 283), 35.7% (n = 356) occurred on the day of delivery and 35.9% (n = 359) occurred after delivery. Half of maternal deaths (50.6%; n = 505) occurred in women aged 20–29 years, 10.3% (n = 103) occurred in women aged under 20 years, 34.5% (n = 344) occurred in women aged 30–39 years and 4.6% (n = 46) occurred in women aged ≥40 years. There was no measured association between the availability of key obstetric resources and the rate of pregnancy‐related death.ConclusionsThe large variation in the rate of pregnancy‐related death, irrespective of resource availability, emphasises that inequality and inequity in health care persists.Tweetable abstractInequality and inequity in pregnancy‐related death persists globally, irrespective of resource availability.
Profitability Development and Resource Reallocation: The Case of Sugar Beet Farming in Germany
Authors: Wimmer Stefan , Sauer Johannes 
Published: May 2020

AbstractFollowing the 2006 reform of the European Union sugar market, and in anticipation of the quota abolition, a reallocation of sugar production has occurred. Using a Lowe quantity index, we evaluate the productivity and profitability of sugar beet farming in Germany from 2004 to 2013. The results show that an increase in total factor productivity partly compensated for losses in terms of trade. Moreover, the contribution of production reallocation to sector productivity growth varied across regions with distinct ownership structures of sugar processing companies. These findings have implications for policy and industry, as it transitions to a liberalised market.
Proposing a new hypothesis: Rickettsia spp. as a mechanism maintaining parapatry between two Australian reptile tick species
Authors: Staines Morgan , Bradford Tessa , Graves Stephen R. , Bull Simon , Gardner Michael G. 
Published: May 2020

AbstractThis study investigates two parasitic reptile ticks — Bothriocroton hydrosauri and Amblyomma limbatum — of the sleepy lizard (Tiliqua rugosa) that abut at a 1–2 km wide parapatric boundary in South Australia. Long‐term research has investigated potential mechanisms to explain the maintenance of this boundary but has not uncovered why the distribution of A. limbatum does not extend further south. It has been previously hypothesised that pathogens may be responsible for maintaining parapatric boundaries. Rickettsia spp. has previously been reported in B. hydrosauri ticks. This study explored whether Rickettsia spp. occurs in co‐occurring A. limbatum. We observed that Rickettsia spp. was absent from all A. limbatum ticks and that 83% of examined B. hydrosauri were found to be positive with a spotted fever group Rickettsia strain. This study puts forward the hypothesis that Rickettsia spp. could contribute to the maintenance of the Mt Mary parapatric boundary between these two tick species. Further work is required to determine whether Rickettsia spp. can be transmitted from B. hydrosauri to A. limbatum and — if transmission can occur — to explore whether Rickettsia is lethal to A. limbatum ticks.
A retrospective review of UVA1 treatment: An Australian experience from a single centre
Authors: Pitney Thomas , Pitney Michael J 
Published: May 2020

AbstractBackgroundThe therapeutic value of ultraviolet A1 (UVA1) phototherapy has been acknowledged for many years. Initially developed predominately for experimental and diagnostic purposes, it was subsequently recognised as a beneficial therapeutic modality in atopic dermatitis and localised scleroderma, and more recently a variety of sclerosing and fibrosing dermatoses, T‐lymphocyte mediated disorders, both inflammatory and infiltrative, and several predominately dermal processes previously unresponsive to current therapies.MethodsWe present a retrospective evaluation of outcomes and treatment tolerability in adult patients using a low dose (30 joules/cm2), regimen administered in our private dermatologic practice, between 2006 and December 2019.ResultsMajor clinical groups represented include atopic dermatitis, localised and systemic sclerodermas, mycosis fungoides, urticarial dermatitis, generalised pruritus and granuloma annulare. Eighty‐seven patients are included in this study with 92% of all patients experiencing a beneficial result, 54% having complete and 38% partial relief of presenting signs and/or symptoms. UVA1 therapy was well tolerated, with no patients ceasing treatment due to adverse effects.ConclusionsUltraviolet A1 is an effective and safe treatment option in many hitherto recalcitrant cutaneous conditions.
The study of scientific map and thematic structure of social work
Authors: Negahban Mohammad Bagher 
Published: May 2020

AbstractThis study investigated the scientific map and thematic structure of Social media. It is a scientometrics research, using quantitative method and citation analysis. In order to draw a scientific map of the research literature in the field of Social media, the data were extracted from the Web of Science database within a specified time period. The retrieved records were formatted using WC10.exe conversion software and were then mapped using VOSviewer software. The findings revealed a growing trend in the number of articles published in the field of Social media, and this number increases on an annual basis. The most widely used subject areas in the field of Social media were identified. High‐frequency keywords such as Social media, education, sociology, social justice, women studies, and psychiatry are the newly emerging and active concepts in this field. Regarding the widely used subject areas in the field of Social media, it was noted that the two areas of Social media and education are ranked first and second as the most frequently used terms. In this study, by the conceptual map found in the field of Social media, it can be concluded that the concepts are highly interconnected. Furthermore, by the interconnectivity and closeness of centrality measures of social concepts illustrated in the provided map, it can be argued that the highest values are attributed to the subject areas of Social media and education.
Molecular typing of equine papillomavirus and autovaccination to treat horses with cutaneous papillomatosis
Authors: Onen EA 
Published: May 2020

ObjectiveThe aim of this study was to evaluate formalin‐inactivated autovaccination to treat cutaneous papillomatosis and to perform molecular typing of the papillomavirus in four horses (two foals, one 3‐year‐old filly and a 5‐year‐old stallion).MethodsHistopathological slides of lesions were prepared and stained with haematoxylin and eosin (H&E) to establish a diagnosis that was based on observation koilocytosis, which is a pathognomonic cytopathic change that is associated with papillomatosis, using light microscopy. Polymerase chain reaction (PCR) and DNA sequencing were performed using the EPV‐R and EPV‐F primer set.ResultsIn histopathological examination, koilocyte formation and occasional intranuclear viral inclusions were detected in the papillomas. A 334‐base pair (bp) fragment of the E2 and L2 genes from the EPV genome was amplified using the EPV‐R and EPV‐F primer set. This fragment contained 215 bp from the E2 gene and 56 bp from the L2 gene; these were found to be 98.78% to 98.97% identical to the known EcPV type‐1 sequence (AF498323).ConclusionThree horses with cutaneous papillomatosis were administered two doses of a formalin‐inactivated preparation of papillomatous lesions at 7‐day intervals. The papillomatous lesions were observed to decrease gradually 1 week after the last vaccination, and all warts had resolved within 2–3 weeks. One horse with cutaneous papillomatosis was left as an unvaccinated control, and no changes to the lesions were noted. To the best of our knowledge, this is the first report of EcPV type‐1 infection, autovaccine preparation and molecular typing in Turkey.
Association of different oral anticoagulants use with renal function worsening in patients with atrial fibrillation: A multicentre cohort study
Authors: Pastori Daniele , Ettorre Evaristo , Lip Gregory Y.H. , Sciacqua Angela , Perticone Francesco , Melillo Francesco , Godino Cosmo , Marcucci Rossella , Berteotti Martina , Violi Francesco , Pignatelli Pasquale , Saliola Mirella , Menichelli Danilo , Casciaro Marco Antonio , Menafra Vito 
Published: May 2020

AimsTo investigate the decline of estimated glomerular filtration rate (eGFR) in patients with atrial fibrillation (AF) treated with vitamin K antagonists (VKAs) or non‐VKA oral anticoagulants (NOACs).MethodsMulticentre prospective cohort study including 1667 patients with nonvalvular AF. The eGFR was assessed by the CKD‐EPI formula at baseline and during follow‐up. The primary endpoint of the study was the median annual decline of eGFR according to VKA (n = 743) or NOAC (n = 924) use. As secondary endpoints, we analysed the transition to eGFR <50 mL/min/1.73 m2 and the eGFR class worsening.ResultsMedian age was 73.7 ± 9.1 years and 43.3% were women. VKA‐treated patients showed an eGFR decline of −2.11 (interquartile range [IQR] –5.68/−0.62), which was −0.27 (IQR –9.00/4.54, P < 0.001 vs VKAs), −1.21 (IQR –9.98/4.02, P = 0.004 vs VKAs) and −1.32 (IQR –8.70/3.99, P = 0.003 vs VKAs) in patients on dabigatran, rivaroxaban and apixaban, respectively.Transition to eGFR <50 mL/min/1.73 m2 was lower in dabigatran‐ and apixaban‐treated patients: odds ratio (OR) 0.492, 95% confidence interval (CI) 0.298‐0.813, P = 0.006 and OR 0.449, 95% CI 0.276‐0.728, P = 0.001, respectively. A lower rate of eGFR class worsening was found in all groups of NOACs compared to VKAs. No difference between full and reduced dose of NOAC was found. Subgroup analysis showed that the association between NOAC and eGFR changes was markedly reduced in diabetic patients.ConclusionPatients prescribed NOACs showed a lower decline of renal function compared to those prescribed VKAs. This effect was partially lost in patients with diabetes.
Latent Ornstein‐Uhlenbeck models for Bayesian analysis of multivariate longitudinal categorical responses
Authors: Tran Trung Dung , Lesaffre Emmanuel , Verbeke Geert , Duyck Joke 
Published: May 2020

AbstractWe propose a Bayesian latent Ornstein‐Uhlenbeck (OU) model to analyze unbalanced longitudinal data of binary and ordinal variables, which are manifestations of fewer continuous latent variables. We focus on the evolution of such latent variables when they continuously change over time. Existing approaches are limited to data collected at regular time intervals. Our proposal makes use of an OU process for the latent variables to overcome this limitation. We show that assuming real eigenvalues for the drift matrix of the OU process, as is frequently done in practice, can lead to biased estimates and/or misleading inference when the true process is oscillating. In contrast, our proposal allows for both real and complex eigenvalues. We illustrate our proposed model with a motivating dataset, containing patients with amyotrophic lateral sclerosis disease. We were interested in how bulbar, cervical, and lumbar functions evolve over time.
Efficacy of immunotherapy targeting the neoantigen derived from epidermal growth factor receptor T790M/C797S mutation in non–small cell lung cancer
Authors: Akazawa Yu , Saito Yuki , Yoshikawa Toshiaki , Saito Keigo , Nosaka Kazuto , Shimomura Manami , Mizuno Shoichi , Nakamoto Yasunari , Nakatsura Tetsuya 
Published: May 2020

AbstractLung cancer is the leading cause of cancer‐related deaths worldwide. Epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI) often have good clinical activity against non–small cell lung cancer (NSCLC) with activating EGFR mutations. Osimertinib, which is a third‐generation EGFR‐TKI, has a clinical effect even on NSCLC harboring the threonine to methionine change at codon 790 of EGFR (EGFR T790M) mutation that causes TKI resistance. However, most NSCLC patients develop acquired resistance to osimertinib within approximately 1 year, and 40% of these patients have the EGFR T790M and cysteine to serine change at codon 797 (C797S) mutations. Therefore, there is an urgent need for the development of novel treatment strategies for NSCLC patients with the EGFR T790M/C797S mutation. In this study, we identified the EGFR T790M/C797S mutation‐derived peptide (790‐799) (MQLMPFGSLL) that binds the human leukocyte antigen (HLA)‐A*02:01, and successfully established EGFR T790M/C797S‐peptide‐specific CTL clones from human PBMC of HLA‐A2 healthy donors. One established CTL clone demonstrated adequate cytotoxicity against T2 cells pulsed with the EGFR T790M/C797S peptide. This CTL clone also had high reactivity against cancer cells that expressed an endogenous EGFR T790M/C797S peptide using an interferon‐γ (IFN‐γ) enzyme‐linked immunospot (ELISPOT) assay. In addition, we demonstrated using a mouse model that EGFR T790M/C797S peptide‐specific CTL were induced by EGFR T790M/C797S peptide vaccine in vivo. These findings suggest that an immunotherapy targeting a neoantigen derived from EGFR T790M/C797S mutation could be a useful novel therapeutic strategy for NSCLC patients with EGFR‐TKI resistance, especially those resistant to osimertinib.
Visual impairment in highly myopic eyes: TheZOC‐BHVIHigh Myopia Cohort Study
Authors: Jiang Yu , Wang Decai , Han Xiaotong , Liao Chimei , Li Zhixi , Scheetz Jane , Jong Monica , Sankaridurg Padmaja , He Mingguang 
Published: May 2020

AbstractImportanceUnderstanding visual impairment (VI) under different definitions and potential risk factors in high myopic is important for future myopia control.BackgroundLimited studies exists investigating the VI among high myopic and with varying VI definitions.DesignRegistry cohort study.ParticipantsEight hundred and eighty‐four participants were from ZOC‐BHVI study.MethodsSubjects aged 7 to 70 years with high myopia were enrolled. Uncorrected visual acuity and best‐corrected visual acuity (UCVA and BCVA), cycloplegic refraction, axial length (AL), corneal curvatures, anterior chamber depth and lens thickness were measured. Axial length/corneal radius of curvature ratio (AL/CR ratio) was calculated. Fundus lesions were graded into five categories. VI and blindness were defined based on the better‐seeing eye according to the World Health Organization (WHO) criteria and US criteria. Multiple logistic regression analysis was used to assess risk factors for VI.Main Outcome MeasuresRates of VI and blindness.ResultsA total of 884 participants were included, with mean (SD) age 18.5 (12.4) years and 46.4% male. Rate of UCVI/blindness were 72.6%/27.3% and 17.9%/82.1% based on WHO and US criteria. With respect to BCVA, 4.1%/5.9% of participants had BCVI using two definitions, whereas the rate for blindness was 0.2% and 0.6%. After adjusting confounders, multiple logistic regression showed that more severe fundus lesions, greater AL/CR ratio were at a higher risk of being VI, both in two definitions (P < .005).Conclusions and RelevanceThe rate of VI and blindness in highly myopic patients varies significantly using different definition. Severe fundus lesions and greater AL/CR ratios were associated with a higher risk of VI.
Developmental trajectories of illicit drug use, prescription drug misuse and cannabis practices among young adult cannabis users in Los Angeles
Authors: Fedorova Ekaterina V. , Schrager Sheree M. , Robinson Lucy F. , Roth Alexis M. , Wong Carolyn F. , Iverson Ellen , Lankenau Stephen E. 
Published: May 2020

AbstractIntroduction and AimsYoung adults have the highest rates of drug use and contribute significantly to the growing population of medical cannabis patients (MCP). This study examined relationships between longitudinal patterns of illicit/prescription drug use/misuse and cannabis practices among young adult cannabis users.Design and MethodsIn 2014–2015, 210 young adult MCP and 156 nonpatient users were recruited in Los Angeles and surveyed annually over four waves. The analytical sample was limited to completers of all four waves (n = 301). Distinct developmental trajectories of illicit drug use and prescription drug misuse were identified. Fixed effects regression analysis evaluated changes in cannabis practices by trajectory groups.ResultsResults supported two‐trajectory solutions (high/low) for illicit drug use and prescription drug misuse. Decreases in use within all four trajectories occurred by wave 4. Low illicit drug use trajectory members were more likely to self‐report medical cannabis use. Membership in both types of high‐use trajectories was associated with use of concentrates and edibles. The prevalence of MCP, edibles use and cannabis days decreased significantly by wave 4.Discussion and ConclusionsWhile alternative cannabis forms use was associated with membership in high drug use trajectories, self‐reported medical cannabis use (not MCP) was negatively associated with high illicit drug use trajectory membership. Reductions in the prevalence of MCP, cannabis days, edibles use and other drug use by wave 4 alongside stable levels of self‐reported medical cannabis use might reflect the changing legal status of cannabis in California, maturing out phenomenon and safer patterns of cannabis use.