bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pension fund management with investment certificates and stochastic dominance
Authors: Vitali Sebastiano , Moriggia Vittorio 
Published: November 2020

AbstractThis paper considers an extension of the common asset universe of a pension fund to investment certificates. Investment certificates are a class of structured products particularly interesting for their special payoff structures and they are acquiring relevancy in the worldwide markets. In fact, some subclasses of certificates offer loss protection and show high liquidity and, thus, they can be very appreciated by pension fund managers. We consider the problem of a pension fund manager who has to implement an Asset and Liability Management model trying to achieve a long-term sustainability. Therefore, we formulate a multi-stage stochastic programming problem adopting a discrete scenario tree and a multi-objective function. We propose a technique to price highly structured products such as investment certificates on a discrete scenario tree. Finally, we solve the investment problem considering some investment certificate types both in term of payoff structure and protection level, and we test whether they are preferred or not to standard hedging contract such as put options. Moreover, we test the inclusion of first-order and second-order stochastic dominance constraints on multiple stages with respect to a benchmark portfolio. Numerical results show that the portfolio composition reacts to the inclusion of the stochastic dominance constraints, and that the optimal portfolio is efficiently able to reach several targets such as liquidity, returns, sponsor’s extraordinary contribution and funding gap.
Mīmāṃsā deontic reasoning using specificity: a proof theoretic approach
Authors: Lellmann Björn , Gulisano Francesca , Ciabattoni Agata 
Published: November 2020

AbstractOver the course of more than two millennia the philosophical school of Mīmāṃsā has thoroughly analyzed normative statements. In this paper we approach a formalization of the deontic system which is applied but never explicitly discussed in Mīmāṃsā to resolve conflicts between deontic statements by giving preference to the more specific ones. We first extend with prohibitions and recommendations the non-normal deontic logic extracted in Ciabattoni et al. (in: TABLEAUX 2015, volume 9323 of LNCS, Springer, 2015) from Mīmāṃsā texts, obtaining a multimodal dyadic version of the deontic logic$$\mathsf {MD}$$MD. Sequent calculus is then used to close a set of prima-facie injunctions under a restricted form of monotonicity, using specificity to avoid conflicts. We establish decidability and complexity results, and investigate the potential use of the resulting system for Mīmāṃsā philosophy and, more generally, for the formal interpretation of normative statements.
Soil C, N and P cycling enzyme responses to nutrient limitation under elevated CO2
Authors: Keane J. Ben , Hoosbeek Marcel R. , Taylor Christopher R. , Miglietta Franco , Phoenix Gareth K. , Hartley Iain P. 
Published: November 2020

Abstract
Elevated CO2 (eCO2) can stimulate plant productivity and increase carbon (C) input to soils, but nutrient limitation restricts productivity. Despite phosphorus (P)-limited ecosystems increasing globally, it is unknown how nutrient cycling, particularly soil microbial extra cellular enzyme activity (EEA), will respond to eCO2 in such ecosystems. Long-term nutrient manipulation plots from adjacent P-limited acidic and limestone grasslands were exposed to eCO2 (600 ppm) provided by a mini-Free Air CO2 Enrichment system. P-limitation was alleviated (35 kg-P ha−1 y−1 (P35)), exacerbated (35 kg-N ha−1 y−1 (N35), 140 kg-N ha−1 y−1 (N140)), or maintained (control (P0N0)) for > 20 years. We measured EEAs of C-, N- and P-cycling enzymes (1,4-β-glucosidase, cellobiohydrolase, N-acetyl β-D-glucosaminidase, leucine aminopeptidase, and acid phosphatase) and compared C:N:P cycling enzyme ratios using a vector analysis. Potential acid phosphatase activity doubled under N additions relative to P0N0 and P35 treatments. Vector analysis revealed reduced C-cycling investment and increased P-cycling investment under eCO2. Vector angle significantly increased with P-limitation (P35 < P0N0 < N35 < N140) indicating relatively greater investment in P-cycling enzymes. The limestone grassland was more C limited than the acidic grassland, characterised by increased vector length, C:N and C:P enzyme ratios. The absence of interactions between grassland type and eCO2 or nutrient treatment for all enzyme indicators signaled consistent responses to changing P-limitation and eCO2 in both grasslands. Our findings suggest that eCO2 reduces C limitation, allowing increased investment in P- and N-cycle enzymes with implications for rates of nutrient cycling, potentially alleviating nutrient limitation of ecosystem productivity under eCO2.

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Color Representations of Ising Models
Authors: Forsström Malin P. 
Published: November 2020

AbstractIn Steif and Tykesson (J Prob 16:899–955, 2019), the authors introduced the so-called general divide and color models. One of the best-known examples of such a model is the Ising model with external field $$ h = 0 $$

h
=
0

, which has a color representation given by the random cluster model. In this paper, we give necessary and sufficient conditions for this color representation to be unique. We also show that if one considers the Ising model on a complete graph, then for many $$ h > 0 $$

h
>
0

, there is no color representation. This shows, in particular, that any generalization of the random cluster model which provides color representations of Ising models with external fields cannot, in general, be a generalized divide and color model. Furthermore, we show that there can be at most finitely many $$ \beta > 0 $$

β
>
0

at which the random cluster model can be continuously extended to a color representation for $$ h \not = 0 $$

h
≠
0

.
A qualitative study of prescribing errors among multi-professional prescribers within an e-prescribing system
Authors: Alshahrani Fahad , Marriott John F. , Cox Anthony R. 
Published: November 2020

AbstractBackground Computerised Physician Order Entry (CPOE) is considered to enhance the safety of prescribing. However, it can have unintended consequences and new forms of prescribing error have been reported. Objective The aim of this study was to explore the causes and contributing factors associated with prescribing errors reported by multidisciplinary prescribers working within a CPOE system. Main Outcome Measure Multidisciplinary prescribers experience of prescribing errors in an CPOE system. Method This qualitative study was conducted in a hospital with a well-established CPOE system. Semi-structured qualitative interviews were conducted with prescribers from the professions of pharmacy, nursing, and medicine. Interviews analysed using a mixed inductive and deductive approach to develop a framework for the causes of error. Results Twenty-three prescribers were interviewed. Six main themes influencing prescribing were found: the system, the prescriber, the patient, the team, the task of prescribing and the work environment. Prominent issues related to CPOE included, incorrect drug name picking, default auto-population of dosages, alert fatigue and remote prescribing. These interacted within a complex prescribing environment. No substantial differences in the experience of CPOE were found between the professions. Conclusion Medical and non-medical prescribers have similar experiences of prescribing errors when using CPOE, aligned with existing published literature about medical prescribing. Causes of electronic prescribing errors are multifactorial in nature and prescribers describe how factors interact to create the conditions errors. While interventions should focus on direct CPOE issues, such as training and design, socio-technical, and environmental aspects of practice remain important.
The Zariski topology-graph of modules over commutative rings II
Authors: Ansari-Toroghy H. , Habibi S. 
Published: November 2020

AbstractLet M be a module over a commutative ring R. In this paper, we continue our study about the Zariski topology-graph $$G(\tau _T)$$

G
(

τ
T

)

which was introduced in Ansari-Toroghy et al. (Commun Algebra 42:3283–3296, 2014). For a non-empty subset T of $$\mathrm{Spec}(M)$$

Spec
(
M
)

, we obtain useful characterizations for those modules M for which $$G(\tau _T)$$

G
(

τ
T

)

is a bipartite graph. Also, we prove that if $$G(\tau _T)$$

G
(

τ
T

)

is a tree, then $$G(\tau _T)$$

G
(

τ
T

)

is a star graph. Moreover, we study coloring of Zariski topology-graphs and investigate the interplay between $$\chi (G(\tau _T))$$

χ
(
G

(

τ
T

)

)

and $$\omega (G(\tau _T))$$

ω
(
G

(

τ
T

)

)

.
Tribological behavior and microstructural evolution of lubricating film of silver matrix self-lubricating nanocomposite
Authors: Kang Xiao , Yu Shuang , Yang Hailin , Sun Yang , Zhang Lei 
Published: November 2020

AbstractThe aim of this study is to fabricate the nanocomposite with low friction and high wear resistance using binary solid lubricant particles. The microstructure and tribological performance of the nanocomposite are evaluated, and the composition and film thickness of the lubricating film are observed and analyzed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The nanocomposite exhibited improved tribological properties with a friction coefficient as low as 0.12 and a low wear rate of 2.17 × 10−6mm3/(N·m) in high-purity nitrogen atmosphere. Decreasing sliding speed can increase lubricating film thickness, and the thickest lubricating film is approximately 125 nm. As the film thickness of the lubricating film exceeded 90 nm, the friction coefficient curves became smooth. In compared with WS2, MoS2can be more effective in forming the transfer layer on the worn surfaces at the initial stage of the tribological process.
Variational symmetries and pluri-Lagrangian structures for integrable hierarchies of PDEs
Authors: Petrera Matteo , Vermeeren Mats 
Published: November 2020

AbstractWe investigate the relation between pluri-Lagrangian hierarchies of 2-dimensional partial differential equations and their variational symmetries. The aim is to generalize to the case of partial differential equations the recent findings in Petrera and Suris (Nonlinear Math. Phys. 24(suppl. 1):121–145, 2017) for ordinary differential equations. We consider hierarchies of 2-dimensional Lagrangian PDEs (many of which have a natural $$(1\,{+}\,1)$$

(
1

+

1
)

-dimensional space-time interpretation) and show that if the flow of each PDE is a variational symmetry of all others, then there exists a pluri-Lagrangian 2-form for the hierarchy. The corresponding multi-time Euler–Lagrange equations coincide with the original system supplied with commuting evolutionary flows induced by the variational symmetries.
SOME HOMOLOGICAL PROPERTIES OF FOURIER ALGEBRAS ON HOMOGENEOUS SPACES
Authors: ESMAILVANDI REZA , NEMATI MEHDI 
Published: November 2020

AbstractLet

$ H $
be a compact subgroup of a locally compact group

$ G $
. We first investigate some (operator) (co)homological properties of the Fourier algebra

$A(G/H)$
of the homogeneous space

$G/H$
such as (operator) approximate biprojectivity and pseudo-contractibility. In particular, we show that

$ A(G/H) $
is operator approximately biprojective if and only if

$ G/H $
is discrete. We also show that

$A(G/H)^{**}$
is boundedly approximately amenable if and only if G is compact and H is open. Finally, we consider the question of existence of weakly compact multipliers on

$A(G/H)$
.
Cross-linguistic syntactic priming in Korean learners of English
Authors: Son Myeongeun 
Published: November 2020

AbstractThis study investigates whether L2 learners develop and share an abstract syntactic representation between an L1 and L2 with different word orders and, if so, whether one language’s unique syntactic features affect the shared representation. Korean (SOV) and English (SVO) have equivalent dative alternations; however, because Korean allows word-order scrambling, several dative structures are available in Korean that do not have English counterparts. In this study’s cross-linguistic syntactic priming experiment, intermediate and advanced Korean learners of English described pictures in English after reading various types of Korean dative sentences. The study found evidence of cross-linguistic syntactic priming between Korean and English, regardless of L2 proficiency, but only when prime and target structures shared identical functional assignments, information structures, and order of thematic roles. These results suggest that, within limits created by language-specific features, L2 learners can develop and share abstract representations between two languages with different word orders.
Counteracting CAR T cell dysfunction
Authors: Poorebrahim Mansour , Melief Jeroen , Pico de Coaña Yago , L. Wickström Stina , Cid-Arregui Angel , Kiessling Rolf 
Published: November 2020

AbstractIn spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Exhaustion and senescence are two critical dysfunctional states that impose a pivotal hurdle for successful CAR T cell therapies. Recently, modified CAR T cells with an “exhaustion-resistant” phenotype have shown superior antitumor functions and prolonged lifespan. In addition, several studies have indicated the feasibility of senescence delay in CAR T cells. Here, we review the latest reports regarding blockade of CAR T cell exhaustion and senescence with a particular focus on the exhaustion-inducing pathways. Subsequently, we describe what potential these latest insights offer for boosting the potency of adoptive cell transfer (ACT) therapies involving CAR T cells. Furthermore, we discuss how induction of costimulation, cytokine exposure, and TME modulation can impact on CAR T cell efficacy and persistence, while potential safety issues associated with reinvigorated CAR T cells will also be addressed.
Toxicity evaluation of an essential oil mixture from the Cretan herbs thyme, Greek sage and Cretan dittany
Authors: Kalyvianaki Konstantina , Malamos Panagiotis , Mastrodimou Niki , Manoura-Zonou Ioanna , Vamvoukaki Rodanthi , Notas George , Malliaraki Niki , Moustou Eleni , Tzardi Maria , Pirintsos Stergios , Lionis Christos , Sourvinos George , Castanas Elias , Kampa Marilena 
Published: November 2020

AbstractThe importance of herbal extracts on health, which was initially based on ethnopharmacological and traditional knowledge, becomes increasingly well documented by numerous experimental and intervention studies. The daily use of beverages from different aromatic plants which becomes more popular nowadays, has been a tradition in Crete, and a habit that has been linked to the longevity seen in the island. Additionally, a certain combination of aromatic plants has been used against common cold and influenza. Interestingly, when such a mixture of essential oils from Cretan herbs (Cretan Aromatic Plants essential oil, CAPeo, from thyme, Greek sage, and Cretan dittany) was formulated, significant antiviral properties were observed in vitro and a significant reduction in the duration and severity of symptoms of patients with upper respiratory tract infections was found in a clinical study. However, since many plants extracts can exert toxic effects, toxicity issues should be properly addressed. In the present work we present an acute and sub-chronic toxicity evaluation for this mixture of aromatic plants’ essential oils in rats. In fact, it is the only toxicity study for Cretan dittany. We report absence of toxicity, rendering the use of the mixture of essential oils from Cretan dittany, Greek sage and thyme as safe.
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells
Authors: Chen Li , Yang Ruirui , Kwan Tony , Tang Chao , Watt Stephen , Zhang Yiming , Bourque Guillaume , Ge Bing , Downes Kate , Frontini Mattia , Ouwehand Willem H. , Lin Jing-wen , Soranzo Nicole , Pastinen Tomi , Chen Lu 
Published: November 2020

AbstractBoth poly(A) enrichment and ribosomal RNA depletion are commonly used for RNA sequencing. Either has its advantages and disadvantages that may lead to biases in the downstream analyses. To better access these effects, we carried out both ribosomal RNA-depleted and poly(A)-selected RNA-seq for CD4+ T naive cells isolated from 40 healthy individuals from the Blueprint Project. For these 40 individuals, the genomic and epigenetic data were also available. This dataset offers a unique opportunity to understand how library construction influences differential gene expression, alternative splicing and molecular QTL (quantitative loci) analyses for human primary cells.
MFRED, 10 second interval real and reactive power for groups of 390 US apartments of varying size and vintage
Authors: Meinrenken Christoph J. , Rauschkolb Noah , Abrol Sanjmeet , Chakrabarty Tuhin , Decalf Victor C. , Hidey Christopher , McKeown Kathleen , Mehmani Ali , Modi Vijay , Culligan Patricia J. 
Published: November 2020

AbstractBuilding electricity is a major component of global energy use and its environmental impacts. Detailed data on residential electricity use have many interrelated research applications, from energy conservation to non-intrusive load monitoring, energy storage, integration of renewables, and electric vs. fossil-based heating. The dataset presented here, Multifamily Residential Electricity Dataset (MFRED), contains the electricity use of 390 apartments, ranging from studios to four-bedroom units. All apartments are located in the Northeastern United States (IECC-climate-zone 4 A), but differ in their heating/cooling system and construction year (early to late 20th century). To adhere to privacy guidelines, data were averaged across 15 apartments each, based on annual electricity use. MFRED includes real and reactive power, at 10-second resolution, for January to December 2019 (246 million data points). The annual average real power per apartment is 343 W (3.27 W/m2 of floor area), with strong variation between seasons and apartment size. Considering its large number of apartments, high time resolution, real and reactive power, and 12-month duration, MFRED is currently unique for the multifamily-sector.
Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome
Authors: Maziotis E. , Sfakianoudis K. , Giannelou P. , Grigoriadis S. , Rapani A. , Tsioulou P. , Nikolettos K. , Pantou A. , Tiptiri-Kourpeti A. , Koutsilieris M. , Asimakopoulos B. , Nikolettos N. , Pantos K. , Simopoulou Mara 
Published: November 2020

AbstractA number of oocyte characteristics have been associated with fertilization, implantation and live-birth rates, albeit without reaching a consensus. This study aims to delineate possible associations between oocyte characteristics, oocyte behavior during intracytoplasmic sperm injection (ICSI), fertilization potential, and laboratory outcomes. Four-hundred and seventy-seven patients, yielding 3452 oocytes, were enrolled in this prospective observational study from 2015 to 2018. Οoplasm granularity was associated with poor embryo quality and higher probabilities of post-ICSI oocytes and embryos discarded in any developmental stage and never selected for embryo transfer or cryopreservation (p < 0.001). Both sudden or difficult ooplasm aspiration, and high or lack of resistance during ICSI were associated with either a poor Zygote-Score or fertilization failure (p < 0.001). Sudden or difficult ooplasm aspiration and high resistance during ICSI penetration were positively associated with resulting to a post-ICSI oocyte or embryo that would be selected for discard. Evaluation of oocyte characteristics and oocyte behavior during ICSI may provide early information regarding laboratory and cycle outcomes. Particularly, ooplasm granularity, and fragmentation of polar body, along with sudden or difficult ooplasm aspiration and high or lack of resistance during ICSI penetration may hinder the outcome of an ICSI cycle. The associations presented herein may contribute towards development of a grading system or a prediction model. Taking into account information on oocytes and ICSI behavior may effectively assist in enhancing IVF outcome rates.
Magnetic susceptibility imaging of human habenula at 3 T
Authors: Yoo Seulki , Kim Joo-won , Schenck John F. , Lee Seung-Kyun 
Published: November 2020

AbstractThe habenula plays an important role in brain reward circuitry and psychiatric conditions. While much work has been done on the function and structure of the habenula in animal models, in vivo imaging studies of the human habenula have been relatively scarce due to its small size, deep brain location, and lack of clear biomarkers for its heterogeneous substructure. In this paper, we report high-resolution (0.5 × 0.5 × 0.8 mm3) MRI of the human habenula with quantitative susceptibility mapping (QSM) at 3 T. By analyzing 48 scan datasets collected from 21 healthy subjects, we found that magnetic susceptibility contrast is highly non-uniform within the habenula and across the subjects. In particular, we observed high prevalence of elevated susceptibility in the posterior subregion of the habenula. Correlation analysis between the susceptibility and the effective transverse relaxation rate (R2*) indicated that localized susceptibility enhancement in the habenula is more associated with increased paramagnetic (such as iron) rather than decreased diamagnetic (such as myelin) sources. Our results suggest that high-resolution QSM could make a potentially useful tool for substructure-resolved in vivo habenula imaging, and provide a groundwork for the future development of magnetic susceptibility as a quantitative biomarker for human habenula studies.
Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha
Authors: Kadrmas Julie L. , Beckerle Mary C. , Yoshigi Masaaki 
Published: November 2020

AbstractPlatelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream signaling have been well defined over the last several decades. In cultured cells after a period of serum deprivation, treatment with PDGF leads to the rapid formation of dramatic, actin-rich Circular Dorsal Ruffles (CDRs). Using CDRs as a robust visual readout of early PDGFR signaling, we have identified several contradictory elements in the widely accepted model of PDGF activity. Employing CRISPR/Cas9 gene editing to disrupt the Pdgfra gene in two different murine cell lines, we show that in addition to the widely accepted function for PDGFR-beta in CDR formation, PDGFR-alpha is also clearly capable of eliciting CDRs. Moreover, we demonstrate activity for heterodimeric PDGF-AB ligand in the vigorous activation of PDGFR-beta homodimers to produce CDRs. These findings are key to a more complete understanding of PDGF ligand-receptor interactions and their downstream signaling consequences. This knowledge will allow for more rigorous experimental design in future studies of PDGFR signaling and its contributions to development and disease.