bluuebunny/crossref_metadata_2025_split huggingface dataset:
A local climate perspective on possible development pathways for Longyearbyen, Svalbard
Authors: Esau Igor , Miles Victoria 
Published: December 2024

Abstract
Arctic human settlements experience formidable challenges from accelerating climate change and environmental transformations. While these towns have demonstrated adaptive resilience, the looming threat of local climate extremes raises concerns about the results of adaptation and mitigation efforts. With the further development of Arctic settlements, it is necessary to consider changes in local climatic conditions, shifting the adaptation focus from regional to local scales. The local climate perspective in this literature synthesis study is built upon constraints from physical climatology, focused on the climate and environment within and around the town of Longyearbyen, Svalbard. The study provides insights into Longyearbyen’s local climate dynamics, including physical mechanisms, climate localisation, factors and trends, as well as their implications. Three model pathways for development are discussed, centred on (1) industrial development, (2) public services, and (3) tourism and conservation. This categorisation is introduced to distinguish development scenario sensitivity to the local climate effects. The synthesis indicates that any development concentrated spatially will amplify local warming and climate change, as positive climate feedback predominate. The study emphasises the need for a comprehensive understanding of the environmental factors sustaining local climatic anomalies.
Tree universality in positional games
Authors: Adamski Grzegorz , Antoniuk Sylwia , Bednarska-Bzdȩga Małgorzata , Clemens Dennis , Hamann Fabian , Mogge Yannick 
Published: December 2024

Abstract
In this paper we consider positional games where the winning sets are edge sets of tree-universal graphs. Specifically, we show that in the unbiased Maker-Breaker game on the edges of the complete graph

$K_n$

, Maker has a strategy to claim a graph which contains copies of all spanning trees with maximum degree at most

$cn/\log (n)$

, for a suitable constant

$c$

and

$n$

being large enough. We also prove an analogous result for Waiter-Client games. Both of our results show that the building player can play at least as good as suggested by the random graph intuition. Moreover, they improve on a special case of earlier results by Johannsen, Krivelevich, and Samotij as well as Han and Yang for Maker-Breaker games.
Are the number of nucleolar precursor body and size of pronuclear correlated with embryo development and ploidy status in 1PN zygotes?: an analysis through the time-lapse monitoring and pre-implantation genetic testing
Authors: Xiong Shun , Wang Jiang , Gao Yang , Wu Lihong , Hao Xiangwei , Zhu Jia hong , Tong Keya , Huang Guoning , Liu Jun xia , Han Wei 
Published: December 2024

AbstractThis study aimed to demonstrate the utilization value of 1PN embryos. The 1PN zygotes collected from December 2021 to September 2022 were included in this study. The embryo development, the pronuclear characteristics, and the genetic constitutions were investigated. The overall blastocyst formation and good-quality blastocyst rates in 1PN zygotes were 22.94 and 16.24%, significantly lower than those of 2PN zygotes (63.25 and 50.23%, respectively, P = 0.000). The pronuclear characteristics were found to be correlated with the developmental potential. When comparing 1PN zygotes that developed into blastocysts to those that arrested, the former exhibited a significantly larger area (749.49 ± 142.77 vs. 634.00 ± 119.05, P = 0.000), a longer diameter of pronuclear (29.81 ± 3.08 vs. 27.30 ± 3.00, P = 0.000), and a greater number of nucleolar precursor body (NPB) (11.56 ± 3.84 vs. 7.19 ± 2.73, P = 0.000). Among the tested embryos, the diploidy euploidy rate was significantly higher in blastocysts in comparison with the arrested embryos (66.67 vs. 11.76%, P = 0.000), which was also significantly higher in IVF-1PN blastocysts than in ICSI-1PN blastocysts (75.44 vs. 25.00%, P = 0.001). However, the pronuclear characteristics were not found to be linked to the chromosomal ploidy once they formed blastocysts.In summary, while the developmental potential of 1PN zygotes is reduced, our study shows that, in addition to the reported pronuclear area and diameter, the number of NPB is also associated with their developmental potential. The 1PN blastocysts exhibit a high diploidy euploidy rate, are recommend to be clinically used post genetic testing, especially for patients who do not have other 2PN embryos available.
Comparing Global Violations of Environmentally Critical Groundwater Discharge Thresholds
Authors: Marinelli B. P. P. , Mohan C. , Gleeson T. , Ludwig F. , de Graaf I. E. M. 
Published: December 2024

AbstractGroundwater is a crucial resource to support surface water bodies via groundwater discharge. In this study, we applied two methods of estimating global environmentally critical groundwater discharge, defined as the flux of groundwater to streamflow necessary to maintain a healthy environment, from 1960 to 2010: the Presumptive Standard stipulates that a standard proportion of groundwater discharge should be maintained at all timesteps, while the Q* is a low‐flow index that focuses on critical periods. We calculated these critical flow thresholds using simulated natural groundwater discharge, and estimated violations of the thresholds when human‐impacted groundwater discharge dropped too low. Our global assessment of the frequency and severity of violations over all timesteps in our study period showed that the Presumptive Standard estimated more frequent and severe violations than the Q*, but that the spatial patterns were similar for both methods. During low‐flow periods, when the relative importance of groundwater to support streamflow is greatest, both methods estimated similar magnitudes of violation frequency and severity. We further compared our results to a method of estimating environmentally critical streamflow, Variable Monthly Flow, which does not explicitly consider groundwater. From the differences in violation frequency between these groundwater‐centric and surface water‐centric methods, we evaluated the influence of including groundwater contributions to streamflow in environmental flow assessments. Our results show that including groundwater in such assessments is particularly important for regions with high groundwater demands in the drier climates of the world, while it is less important for regions with low groundwater demands and more humid climates.
Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis
Authors: Yu Anze , Fu Liangmin , Jing Lanyu , Wang Yinghan , Ma Zifang , Zhou Xinwei , Yang Rui , Liu Jinhui , Hu Jiao , Feng Wei , Yang Taowei , Chen Zhenhua , Zu Xiongbing , Chen Wei , Chen Junxing , Luo Junhang 
Published: December 2024

AbstractThe impact of amino acids on tumor immunotherapy is gradually being uncovered. In this study, we screened various essential and non-essential amino acids and found that methionine enhances mRNA methylation and reduced the activation of Type I interferon pathway in bladder cancer. Through RNA sequencing, point mutations, MB49 mouse tumor models, and single-cell RNA sequencing, we demonstrated that high methionine levels elevate the expression of m6A reader YTHDF1, promoting the degradation of RIG-I, thereby inhibiting the RIG-I/MAVS-mediated IFN-I pathway and reducing the efficacy of tumor immunotherapy. Additionally, immunoprecipitation and mass spectrometry revealed that YTHDF1 binds to the eukaryotic translation initiation factor eIF5B, which acts on PD-L1 mRNA to enhance its translation and promote immune evasion. By intravesical administration of oncolytic bacteria VNP20009, we effectively depleted methionine locally, significantly prolonging mouse survival and enhancing immune cell infiltration and differentiation within tumors. Multiplex immunofluorescence assays in bladder cancer immunotherapy patients confirmed our findings. Our research elucidates two mechanisms by which methionine inhibits bladder cancer immunotherapy and proposes a targeted methionine depletion strategy that advances research while minimizing nutritional impact on patients.
Parahydrogen-enhanced magnetic resonance identification of intermediates in [Fe]-hydrogenase catalysis
Authors: Kaltschnee Lukas , Pravdivtsev Andrey N. , Gehl Manuel , Huang Gangfeng , Stoychev Georgi L. , Riplinger Christoph , Keitel Maximilian , Neese Frank , Hövener Jan-Bernd , Auer Alexander A. , Griesinger Christian , Shima Seigo , Glöggler Stefan 
Published: December 2024

Abstract
Hydrogenases are widespread metalloenzymes used for the activation and production of molecular hydrogen. Understanding the catalytic mechanism of hydrogenases can help to establish industrial (bio)catalytic hydrogen production and conversion. Here we show the observation of so-far undetectable intermediates of [Fe]-hydrogenase in its catalytic cycle. We observed these intermediates by applying a signal-enhancing NMR technique based on parahydrogen. Molecular hydrogen occurs as orthohydrogen or parahydrogen, depending on its nuclear spin state. We found that catalytic conversion of parahydrogen by the [Fe]-hydrogenase leads to notably enhanced NMR signals (parahydrogen-induced polarization, PHIP). The observed signals encode information about how the [Fe]-hydrogenase binds hydrogen during catalysis. Our data support models of the catalytic mechanism that involve the formation of a hydride at the iron centre. Moreover, PHIP enabled studying the binding kinetics. This work demonstrates the hitherto unexploited power of PHIP to study catalytic mechanisms of hydrogenases.
La rééducation myofonctionnelle oro-faciale avec gouttière préfabriquée : simple option thérapeutique ou nécessité médicale
Authors: Amat Philippe , Béry Alain 
Published: December 2024

Les données publiées, même de niveaux de biais hétérogènes, concluent à la supériorité d’une rééducation myofonctionnelle oro-faciale (RMOF) combinée au port d’une gouttière de rééducation préfabriquée (GRP), comparée à la mise en œuvre d’une rééducation myofonctionnelle oro-faciale sans gouttière de rééducation préfabriquée sur l’amélioration de paramètres fonctionnels (ventilation, indice d’apnée hypopnée, déglutition, équilibre musculaire) et anthropométriques (dentoalvéolaires et squelettiques).
Du fait de la supériorité d’une rééducation myofonctionnelle oro-faciale avec gouttière de rééducation préfabriquée, il est également souhaitable que les orthodontistes remettent systématiquement une gouttière de rééducation préfabriquée à chacun des patients qu’ils adressent à un rééducateur spécialisé, kinésithérapeute ou orthophoniste, pour une rééducation myofonctionnelle oro-faciale spécialisée.
Cette approche de la rééducation myofonctionnelle oro-faciale avec gouttière de rééducation préfabriquée apparaît comme un nécessaire changement de paradigme, dont il semble utile de faire bénéficier nos patients. Ne pas le faire pourrait être pour le patient assimilé à une perte de chance et si un praticien prétextait ne pas être au courant, il montrerait ipso facto son manquement à l’obligation de formation continue.
Cobalt-Catalyzed Three-Component Synthesis of α-Substituted N-Sulfonyl Amines via C(sp2)–H Bond Activation
Authors: Manolikakes Georg , Olu-Igbiloba Oluwaseun A. , Sitzmann Helmut 
Published: December 2024

AbstractHerein, we report a three-component synthesis of α-substituted N-sulfonyl amines from aryl aldehydes, primary sulfonamides, and (hetero)arenes as readily available building blocks. This method is based on the direct functionalization of (hetero)arenes via a cobalt-catalyzed C(sp2)–H bond activation. It enables the modular synthesis of highly substituted sulfonamides as interesting scaffolds for pharmaceutical applications in good yields with a high degree of structural diversity. The applicability of this method in the context of pharmaceutical research was demonstrated by the late-stage modification of active pharmaceutical ingredients and drug-like compounds. Overall, this process offers an interesting and atom-economical alternative to classical approaches for the preparation of α-arylated amines, such as the Petasis reactions or similar processes based on organometallic reagents.
Enhancing Surgical Outcomes: Evaluating the Impact of Implementing the World Health Organization Surgical Safety Checklist—A Prospective Cross-Sectional Study
Authors: Gasoma ElMuhtadi B. Y. , Marouf Mohamed A. 
Published: December 2024

Abstract
Background Globally, surgical care plays a vital role in health care. Unfortunately, complications arise in approximately 5 to 18% of surgical procedures. However, research has shown that following the surgical safety checklist provided by the World Health Organization (WHO) can significantly reduce these complications and surgery-related fatalities. The objective of this study was to assess the accuracy and completion of the WHO Surgical Safety Checklist.
Materials and Method From October 3, 2022 to February 28, 2023, a comprehensive observational study was conducted involving 300 patients who underwent elective and emergency surgeries. The completion rates for the different stages of surgery, namely sign-in, time-out, and sign-out, were determined using the SPSS 22.0 software.
Result In our research, we specifically examined the completion of the checklist for 300 patients who underwent important procedures within a span of 5 months. For each patient, we ensured that their identities, procedures, and consent were verified with a 100% success rate. Additionally, we thoroughly checked the anesthesia equipment and drugs for safety in every case. Furthermore, all essential images were consistently displayed for each patient, achieving a 100% adherence to this crucial aspect of the process.
Conclusion In general, the level of completeness of the checklist was satisfactory across the sign-in, time-out, and sign-out phases. While this study did not assess the specific outcomes, it is presumed that incomplete data may have exposed patients to potential perioperative complications.
The Ideograph-Based Linguistic Chineseness: Evidence from the Disappearance of Derivational Morphology
Authors: Zhang Liulin 
Published: December 2024

AbstractMany Classical Chinese words were derived through tonal/voicing alternations. New characters were specifically created for some derived words, while other derived words kept using the original characters, making the original characters multifunctional. In the evolution of the Chinese language, those derivations represented by specifically created characters have mostly been preserved, while multifunctional characters were not likely to stay multifunctional: it is common to eliminate some form-meaning pairs, leaving each character with only one pronunciation. Meanwhile, the form-meaning pairs represented by characters began to compound with each other, reducing syntactic freedom. Ideographic characters thereby stabilized the basic units, that is, root morphemes, for the Chinese language, while those phonological alternations that were not clearly represented in writing mostly disappeared, making the language increasingly analytic. This finding sheds light on the stabilizing effect of writing on (the spoken) language and thus challenges the traditional view that writing is secondary to language.
The Relations between Charles Goodwin’s Interactional Linguistics and Semiotics: Some Reflections on Multimodality and on the Diagram in Scientific Discourse
Authors: Dondero Maria Giulia 
Published: December 2024

AbstractThis text addresses the connection between the work of Charles Goodwin in interactional linguistics and contemporary semiotics, notably that of the structuralist Paris School, known today as Greimasian and post-Greimasian semiotics. The latter constitutes scholarship having further developed some great distinctions formulated by Ferdinand de Saussure, such as the one between langue and parole, in the study of multimodality (relations between natural and nonverbal languages). However, Goodwin’s texts consider not only Saussure’s structuralist semiology but also another semiotics, that is, the American cognitive Peircean tradition, specifically regarding the topic of diagrammatic reasoning in multimodal discourse. This article seeks to discuss these two semiotic approaches that I consider as a semiotic foundation of Goodwin’s work, helping him to study the creativity at play in multimodal languages and in scientific diagrammatic devices. I will first return to Goodwin’s contributions in order to reformulate the question of the relations between verbal, visual, and gestural languages in his notational system (transcription of exchanges). Second, I will examine the case of the dynamics of inscriptions in science, raising the issue of the diagram. Third, I will explore the points of encounter between Goodwin’s conception of the substrate of interactions and Jacques Fontanille’s enunciative praxis, in order to consider the dynamic relationship between sedimentation and transformation in social and scientific practices.
Novel topological phenomena of timelike circular orbits for charged test particles
Authors: Ye Xu , Wei Shao-Wen 
Published: December 2024

Abstract
The topological approach has recently been successfully employed to investigate timelike circular orbits (TCOs) for massive neutral test particles. The observed vanishing topological number implies that these TCOs occur in pairs. However, the behavior of charged test particles in this regard remains unexplored. To address this issue, our study focuses on examining the influence of particle charge on the topology of TCOs within a spherically symmetrical black hole spacetime holding a nonvanishing radial electric field. We consider four distinct cases based on the charges of the particle and the black hole: unlike strong charge, unlike weak charge, like weak charge, and like strong charge. For each case, we calculate the corresponding topological number. Our results reveal that when the charge is large enough, the topological number takes a value of -1 instead of 0, which differs from the neutral particle scenario. Consequently, in cases of small charges, the TCOs appear in pairs, whereas in cases of larger charges, an additional unstable TCO emerges. These findings shed light on the influence of the particle charge on the topological properties and number of TCOs.
Dynamical systems analysis of a cosmological model with interacting Umami Chaplygin fluid in adiabatic particle creation mechanism: some bouncing features
Authors: Mandal Goutam , Biswas Sujay Kr 
Published: December 2024

Abstract
The present work aims to investigate an interacting Umami Chaplygin gas (UCG) in the background dynamics of a spatially flat Friedmann–Lemaitre–Robertson–Walker Universe when adiabatic particle creation is allowed. Here, the Universe is taken to be an open thermodynamical model where the particle is created irreversibly and consequently, the creation pressure comes into the energy-momentum tensor of the material content. The particle creation rate is assumed to have a linear relationship with the Hubble parameter (

Γ
∝
H

) and the created particle is dark matter (pressureless). With this creation rate a single fluid model studied and found no phase transition. Then, we studied an interacting two-fluid model where second fluid is taken as perfect fluid equation of state (EOS) and late-time acceleration is obtained. Next, interacting UCG is studied in context of particle creation. Dynamical stability of the model is performed by perturbing the autonomous system around critical points upto first order. Classical stability of the model is also studied at each critical point. This study explores some cosmologically viable scenarios when we constrain the model parameters. Some critical points exhibit the accelerated de Sitter expansion of the Universe at both the early phase as well as the late phase of evolution which is characterized by completely Umami Chaplygin fluid EOS. Scaling solutions are also described by some other critical points showing late-time accelerated attractors in phase space satisfying present observational data, and solving the coincidence problem. In a specific region of parameters, a sequence of critical points is achieved exhibiting a unified cosmic evolution of the Universe starting from early inflation (represented by source point), which is followed by a decelerated intermediate phase (described by saddle solution), and finally goes through the late-time dark energy dominated Universe (represented by stable point). Finally, non-singular bouncing behavior of the Universe is also investigated for this model numerically.
Simulating binary black hole mergers using discontinuous Galerkin methods
Authors: Lovelace Geoffrey , Nelli Kyle C , Deppe Nils , Vu Nils L , Throwe William , Bonilla Marceline S , Carpenter Alexander , Kidder Lawrence E , Macedo Alexandra , Scheel Mark A , Afram Azer , Boyle Michael , Ceja Andrea , Giesler Matthew , Habib Sarah , Jones Ken Z , Kumar Prayush , Lara Guillermo , Melchor Denyz , Mendes Iago B , Mitman Keefe , Morales Marlo , Moxon Jordan , O’Shea Eamonn , Pannone Kyle , Pfeiffer Harald P , Ramirez-Aguilar Teresita , Sanchez Jennifer , Tellez Daniel , Teukolsky Saul A , Wittek Nikolas A 
Published: December 2024

Abstract
Binary black holes are the most abundant source of gravitational-wave observations. Gravitational-wave observatories in the next decade will require tremendous increases in the accuracy of numerical waveforms modeling binary black holes, compared to today’s state of the art. One approach to achieving the required accuracy is using spectral-type methods that scale to many processors. Using the SpECTRE numerical-relativity (NR) code, we present the first simulations of a binary black hole inspiral, merger, and ringdown using discontinuous Galerkin (DG) methods. The efficiency of DG methods allows us to evolve the binary through ∼ 18 orbits at reasonable computational cost. We then use SpECTRE’s Cauchy Characteristic Evolution (CCE) code to extract the gravitational waves at future null infinity. The open-source nature of SpECTRE means this is the first time a spectral-type method for simulating binary black hole evolutions is available to the entire NR community.