bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA HOXA-AS3 promotes the progression of oral squamous cell carcinoma via inhibiting miR-218-5p
Authors: Zhao Yue , Yao Rui 
Published: February 2020

Abstract
Objective: The aim of the present study was to investigate the roles and molecular mechanism of long non-coding RNA (lncRNA) HOXA-AS3 in the progression of oral squamous cell carcinoma (OSCC). Methods : The expression of HOXA-AS3 and miR-218-5p was detected in OSCC tissues and cells using quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) and colony formation assays were used to examine the effects of HOXA-AS3 and miR-218-5p on the proliferation of OSCC cells. Luciferase reporter gene assay was used to confirm the directly binding condition between lncRNA HOXA-AS3 and miR-218-5p in OSCC cells. Subsequently, a tumor xenograft model was used to determine the function of HOXA-AS3 in OSCC growth in vivo . Results: The relative expression of lncRNA HOXA-AS3 was observably upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Knockdown of HOXA-AS3 significantly inhibited the cell proliferation and colony formation of OSCC in vitro and in vivo . Bioinformatics and luciferase reporter assays showed that HOXA-AS3 directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and there was an inverse correlation between them. Silencing miR-218-5p reversed the inhibitory effect of lncRNA HOXA-AS3 knockdown on the proliferative potential of OSCC cells. Conclusion: In summary, our study illustrated lncRNA HOXA-AS3 promoted cancer cell proliferation in OSCC possibly by inhibiting miR-218-5p for the first time, which provides a new target or a potential diagnostic biomarker of the treatment for OSCC.
Sensing of NO, NO2, and SO2 on two dimensional WS2 doped with Al, P, and Fe: An ab initio study
Authors: cao jiamu , zhou jing , shi jianing , zhang yufeng , chen junyu , wang weiqi , liu xiaowei 
Published: February 2020

Abstract
Owing to their harmful and polluting the environment, nitrogen oxides and sulfur dioxide are expected to monitor when they are used. However, the widespread use of gas sensing methods presents obstacles in terms of portability or stability. Hence, a better detect way needs to be found urgently. The success of graphene-based gas sensors has stimulated interest in two-dimensional (2D) materials in the gas sensing area. Transition metal dichalcogenides (TMDs), such as MoS2 or WS2, are considered to have the high-performance potential for gas sensors. Unfortunately, when used as a gas sensor, the sensing response of the pristine TMDs is greatly affected by a number of gas molecules that are too weak to be detected. Herein, to evaluate the sensing capability of Al, P, and Fe-doped WS2 to NO, NO2, and SO2, the molecular model of the adsorption systems was constructed, and density functional theory (DFT) was used to calculate the adsorption behavior of these gases. The binding force of all the doped-WS2 to the harmful gas molecules is much stronger than that of the pristine WS2. According to the results of adsorption energy, band structure, and state density, Al-doped WS2 has the potential to be used as NO and SO2 gas sensor, while P-doped WS2 is selective to NO. This work opens up a new reference for choosing appropriate doping types on 2D materials for noxious gas sensing.
Phenylboronic Ester-Modified Anionic Micelles for ROS-Stimuli Response in HeLa Cell
Authors: Wang Qiyan , Xu Yisong , Zhang Nanxia , Dong Zhipeng , Zhao Bonan , Liu Lin C , Lu Tao , Wang Yue 
Published: February 2020

Abstract
Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE（Phenylboronic Ester） group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tuomr activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.
Thyroid hormone associated with Acanthosis Nigricans and fat distribution in obese patients
Authors: wang xingchun , Chen Yao , Ma Bingwei , Sheng Chunjun , Yang Peng , Qu Shen 
Published: February 2020

Abstract
Background: Obesity is more easier exhibiting subclinical hypothyroidism (SH) and acanthosis nigricans (AN). We aimed to elucidate the thyroid hormone levels in obese patients and its association with fat distribution and AN. Methods: In this cross-sectional study, 202 obese men and 239 obese women were enrolled. Anthropometric measurements, glucose-lipid metabolism, thyroid hormone levels and fat distribution were measured. SH were defined by thyroid stimulating hormone (TSH) less than 2.5 mU/L. Results: 1) The prevalence of AN was significantly higher in obese group with SH than without SH (47.3% vs. 36.9%, P=0.035). Number of obese women with SH were larger than men (38.1% vs. 28.2%, P=0.029). Obese women have higher TSH levels, lower free triiodothyronine (FT3) and free thyroxin (FT4) than obese men (all P<0.01). Body mass index (BMI), waist/hip ratio (WHR), glycosylated hemoglobin (HGB), homeostasis model of assessment for insulin resistance index (HOMA-IR) were significantly lower in obese women than men (all P <0.05). 2) In all obesity, FT3 was significantly positively associated with height, weight, NC, WC, WHR, SBP, DBP, FINS, UA and negatively with HDL-C (all P <0.05). FT4 was significantly positively associated with height, weight, BMI, NC, WC, SBP, DBP, UA, HGB and FBG (all P <0.05). TSH was negatively with FBG and HGB (all P <0.05). 3) FT3 was positively with Peripheral fatmass, total leanmass and negatively with Total Fat% and Trunk/peripheral fatmass (P=0.025;P=0.029;P<0.001;P=0.034), FT4 was also positively with total leanmass and negatively with Total Fat%(P=0.008; P=0.017), and TSH was positively with Total Fat%(P=0.032). Conclusion: AN is more likely to happen in the obesity with SH. Obese women have higher probability of SH than men. Relatively slightly insufficient of thyroid function with higher TSH may be protective factor in obese women with better metabolism. Thyroid hormone may beneficial to improving fat distribution and building lean mass in the obesity.
Opportunities for the development of drowning interventions in West Bengal, India: A review of policy and government programs
Authors: Gupta Medhavi , Zwi Anthony B , Jagnoor Jagnoor 
Published: February 2020

Abstract
Background Four million people living in the Indian Sundarbans region in the state of West Bengal face a particularly high risk of drowning due to rurality, presence of open water, lack of accessible health systems and poor infrastructure. Although the World Health Organization has identified a number of interventions that may prevent drowning in rural low-and middle-income country contexts, no drowning interventions are currently implemented in this region. Interventions that build on existing policy targets or government programs are more likely to be sustainable and scalable. Methods A detailed content review of national and state policy (West Bengal) was conducted to identify policy principles and/or specific government programs that may be leveraged for drowning interventions. The enablers and barriers of these programs as well as their implementation reach were assessed through a systematic literature review. Identified policies and programs were also assessed to understand how they catered for underserved groups and their implications for equity. Results Three programs may be leveraged for drowning interventions: the Integrated Child Development Scheme (ICDS), Self-Help Group (SHG) and Accredited Social Health Activist (ASHA) programs. All three had high coverage in West Bengal and considered underserved groups such as women and rural populations. Conclusions This is the first systematic analysis of both policy content and execution of government programs to provide comprehensive insights into possible implementation strategies for a health intervention, in this case drowning. Programs targeting specific health outcomes should consider interventions outside of the health sector that address social determinants of health. This may enable the program to better align with relevant government agendas and increase sustainability.
The effect of sinomenine eye drops on experimental mice dry eye
Authors: Li Hui , Yan Liang , Lu Peirong 
Published: February 2020

Abstract
Background: To investigate the effect of topical sinomenine (SIN) on ocular surface damage in dry eye of experimental mice. Study Design: Laboratory Investigation. Methods: Experimental dry eye was created using scopolamine hydrobromide in female C57BL/6 mice. Eye drops consisting of 0.05%, or 0.1% SIN or phosphate-buffered saline (PBS) were applied to the dry eye of experimental mice. Tear product and corneal staining scores were measured at 7 and 14 days after treatment. Interleukin (IL)-1 β and tumour necrosis factor (TNF) -α levels in the SIN groups at 14 days after treatment were compared with those of other groups. Results: Mice treated with 0.05% or 0.1% SIN showed a significant improvement in tear product and corneal irregularity compared to the control and PBS-treated groups. A significant decrease in the levels of IL-1 β and TNF- α was observed in the 0.05% and 0.01% SIN-treated groups. Conclusions: Topical SIN eye drop application can effectively improve clinical signs and decrease inflammation in the ocular surface, and alleviate ocular surface damage in dry eye.
Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton
Authors: Shahzad Kashif , Zhang Xuexian , Guo Liping , Qi Tingxiang , Tang Huini , Zhang Meng , Zhang Bingbing , Wang Hailin , Qiao Xiuqin , Feng Juanjuan , Wu Jianyong , Xing Chaozhu 
Published: February 2020

Abstract
Background: Heterosis breeding is the most useful method for yield increase around the globe. Heterosis is an intriguing process to develop superior offspring to either parent in the desired character. The biomass vigor produced during seedling emergence stage has a direct influence on yield heterosis in plants. Unfortunately, the genetic basis of early biomass vigor in cotton is poorly understood.
Results : Three stable performing F 1 hybrids varying in yield heterosis named as high, medium and low hybrids with their inbred parents were used in this study. Phenotypically, these hybrids established noticeable biomass heterosis during the early stage of seedling growth in the field. Transcriptome analysis of root and leaf revealed that hybrids showed many differentially expressed genes (DEGs) relative to their parents, while the comparison of inbred parents showed limited number of DEGs indicating similarity in their genetic constitution. Further analysis indicated expression patterns of most DEGs were overdominant in both tissues of hybrids. According to GO results, functions of overdominance genes in leaf were enriched for chloroplast, membrane, and protein binding, whereas functions of overdominance genes in root were enriched for plasma membrane, extracellular region, and responses to stress. We found several genes of circadian rhythm pathway related to LATE ELONGATED HYPOCOTYL (LHY) showed downregulated overdominant expressions in both tissues of hybrids. In addition to circadian rhythm, several leaf genes related to Aux/IAA regulation, and many root genes involved in peroxidase activity also showed overdominant expressions in hybrids. Twelve genes involved in circadian rhythm plant were selected to perform qRT-PCR analysis to confirm the accuracy of RNA-seq results.
Conclusions: Through genome-wide comparative transcriptome analysis, we strongly predict that overdominance at gene expression level plays a pivotal role in early biomass vigor of hybrids. The combinational contribution of circadian rhythm and other metabolic process may control vigorous growth in hybrids. Our result provides an important foundation for dissecting molecular mechanisms of biomass vigor in hybrid cotton.
The Cr-Zr-Ca armalcolite in lunar rocks is loveringite: Constraints from electron backscatter diffraction measurements
Authors: Zhang Ai-Cheng , Pang Run-Lian , Sakamoto Naoya , Yurimoto Hisayoshi 
Published: February 2020

Abstract
“Cr-Zr-Ca armalcolite” is a mineral originally found in Apollo samples five decades ago. However, no structural information has been obtained for this mineral. In this study, we report a new occurrence of “Cr-Zr-Ca armalcolite” and its associated mineral assemblage in an Mg-suite lithic clast (Clast-20) from the brecciated lunar meteorite Northwest Africa 8182. In this lithic clast, plagioclase (An = 88–91), pyroxene (Mg#[Mg/(Mg+Fe)] = 0.87–0.91) and olivine (Mg# = 0.86–0.87) are the major rock-forming minerals. Armalcolite and “Cr-Zr-Ca armalcolite” are observed with other minor phases including ilmenite, chromite, rutile, fluorapatite, merrillite, monazite, FeNi metal, and Fe-sulfide. Based on 38 oxygen atoms, the chemical formula of “Cr-Zr-Ca armalcolite” is (Ca0.99Na0.01)Σ1.00(Ti14.22Fe2.06Cr2.01 Mg1.20Zr0.54Al0.49Ca0.21Y0.05Mn0.04Ce0.03Si0.03La0.01Nd0.01Dy0.01)Σ20.91O38. Electron backscatter diffraction (EBSD) results reveal that the “Cr-Zr-Ca armalcolite” has a loveringite R3 structure, differing from the armalcolite Bbmm structure. The estimated hexagonal cell parameters a and c of “Cr-Zr-Ca armalcolite” are 10.55 and 20.85 Å, respectively. These structural and compositional features indicate that “Cr-Zr-Ca armalcolite” is loveringite, not belonging to the armalcolite family. Comparison with “Cr-Zr-Ca armalcolite” and loveringite of other occurrences implies that loveringite might be an important carrier of rare earth elements in lunar Mg-suite rocks. The compositional features of plagioclase and mafic silicate minerals in Clast-20 differ from those in other Mg-suite lithic clasts from Apollo samples and lunar meteorites, indicating that Clast-20 represents a new example of diverse lunar Mg-suite lithic clasts.
Ti diffusion in feldspar
Authors: Cherniak D. J. , Watson E. B. 
Published: February 2020

Abstract
Chemical diffusion of Ti has been measured in natural K-feldspar and plagioclase. The sources of diffusant used were TiO2 powders or pre-annealed mixtures of TiO2 and Al2O3. Experiments were run in crimped Pt capsules in air or in sealed silica glass capsules with solid buffers (to buffer at NNO). Rutherford backscattering spectrometry (RBS) was used to measure Ti diffusion profiles. From these measurements, the following Arrhenius relations are obtained for diffusion normal to (001):For oligoclase, over the temperature range 750–1050 °C:DOlig=6.67×10-12exp(-207±31kJ/mol/RT)m2s-1For labradorite, over the temperature range 900–1150 °C:DLab=of4.37×10-14exp(-181±57kJ/mol/RT)m2s-1For K-feldspar, over the temperature range 800–1000 °C:DKsp=3.01×10-6exp(-342±47kJ/mol/RT)m2s-1.
Diffusivities for experiments buffered at NNO are similar to those run in air, and the presence of hydrous species appears to have little effect on Ti diffusion. Ti diffusion also shows little evidence of anisotropy. In plagioclase, there appears to be a dependence of Ti diffusion on An content of the feldspar, with Ti diffusing more slowly in more calcic plagioclase. This trend is similar to that observed for other cations in plagioclase, including Sr, Pb, Ba, REE, Si, and Mg. In the case of Ti, an increase of 30% in An content would result in an approximate decrease in diffusivity of an order of magnitude.
These data indicate that feldspar should be moderately retentive of Ti chemical signatures, depending on feldspar composition. Ti will be more resistant to diffusional alteration than Sr. For example, Ti zoning on a 50 μm scale in oligoclase would be preserved at 600 °C for durations of ~1 million years, with Sr zoning preserved only for ~70 000 yr at this temperature. These new data for a trace impurity that is relatively slow-diffusing and ubiquitous in feldspars (Hoff and Watson 2018) have the potential to extend the scope and applicability of t-T models for crustal rocks based on measurements of trace elements in feldspars.
Effects of composition and pressure on electronic states of iron in bridgmanite
Authors: Dorfman Susannah M. , Potapkin Vasily , Lv Mingda , Greenberg Eran , Kupenko Ilya , Chumakov Aleksandr I. , Bi Wenli , Alp E. Ercan , Liu Jiachao , Magrez Arnaud , Dutton Siân E. , Cava Robert J. , McCammon Catherine A. , Gillet Philippe 
Published: February 2020

Abstract
Electronic states of iron in the lower mantle's dominant mineral, (Mg,Fe,Al)(Fe,Al,Si)O3 bridgmanite, control physical properties of the mantle including density, elasticity, and electrical and thermal conductivity. However, the determination of electronic states of iron has been controversial, in part due to different interpretations of Mössbauer spectroscopy results used to identify spin state, valence state, and site occupancy of iron. We applied energy-domain Mössbauer spectroscopy to a set of four bridgmanite samples spanning a wide range of compositions: 10–50% Fe/total cations, 0–25% Al/total cations, 12–100% Fe3+/total Fe. Measurements performed in the diamond-anvil cell at pressures up to 76 GPa below and above the high to low spin transition in Fe3+ provide a Mössbauer reference library for bridgmanite and demonstrate the effects of pressure and composition on electronic states of iron. Results indicate that although the spin transition in Fe3+ in the bridgmanite B-site occurs as predicted, it does not strongly affect the observed quadrupole splitting of 1.4 mm/s, and only decreases center shift for this site to 0 mm/s at ~70 GPa. Thus center shift can easily distinguish Fe3+ from Fe2+ at high pressure, which exhibits two distinct Mössbauer sites with center shift ~1 mm/s and quadrupole splitting 2.4–3.1 and 3.9 mm/s at ~70 GPa. Correct quantification of Fe3+/total Fe in bridgmanite is required to constrain the effects of composition and redox states in experimental measurements of seismic properties of bridgmanite. In Fe-rich, mixed-valence bridgmanite at deep-mantle-relevant pressures, up to ~20% of the Fe may be a Fe2.5+ charge transfer component, which should enhance electrical and thermal conductivity in Fe-rich heterogeneities at the base of Earth's mantle.
Investigation of PISA 2015 Reading Ability Achievement of Turkish Students in Terms of Student and School Level Variables
Authors: ÇELİK Kazım , YURDAKUL Ahmet 
Published: February 2020

The aim of this study is to determine the
students-level and school-level factors that are related to reading ability achievement
of students who participated PISA 2015 (Programme for International Student
Assessment) from Turkey. The effects of the student and school level factors on
reading achievement of students were tested by 2 level hierarchical linear
model. According to the findings, there
are differences between schools in terms of students' reading ability scores in
Turkey. When the findings of the effects of the student level variables on the
reading ability scores are examined; mother’s socio-economic status, parental
emotional support, and unfair teacher behavior variables seem to affect
students' reading ability achievement. When the findings of the effects of the
school level variables on the reading ability scores are examined; school size,
teacher education level, and student behavior that hinders learning variables
have a significant effect on the average reading ability scores of schools.
When the student and school level variables mentioned above were modeled
together, the significant effect of the school size variable was lost while the
teacher education level and the student behavior that hinders learning
variables continued to have a significant effect on the schools average reading
ability scores.
Engaging with the WASH enabling environment
Authors: Tyndale-Biscoe Paul , Crawford Paul , Bailey Bruce 
Published: February 2020

Abstract
Sustainability of WASH interventions remains a challenge despite progress and evolution in thinking in the sector. Traditional approaches based on a community engagement model have failed to connect communities to the broader enabling environment necessary for ongoing WASH services. The Australian Government's AUD103 million Civil Society WASH Fund (2013–2018) mobilised civil society organisations (CSO) to engage with the WASH enabling environment by supporting the performance of WASH sector ‘change agents’ — people with primary responsibility for WASH service delivery. This approach represented an overt shift away from previous phases that saw CSOs directly delivering infrastructure and services into communities. This paper presents three tools – Strategy Mapping, Context Mapping and the Change Agent Assessment Tool – developed by the Fund's M&E Panel to test the Fund's Theory of Change (ToC) that greater engagement with the enabling environment would enhance the sustainability of WASH services. These tools were primarily developed to facilitate structured reflection by project teams about the relevance and effectiveness of their approaches, but ultimately provided valuable datasets that appear to authenticate the Fund ToC – suggesting that investing in the enabling environment for WASH services is a more sustainable policy proposition than investing directly in community WASH infrastructure and services.
This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
Photo-assisted heterogeneous Fenton-like process for treatment of PNP wastewater
Authors: Ban F. C. , Zheng X. T. , Zhang H. Y. 
Published: February 2020

Abstract
The purpose of this study was to investigate the effect of photo-assisted heterogeneous Fenton on p-nitrophenol (PNP) wastewater treatment by a homemade reactor. Supported Fe-Ce/Al2O3 was used as a catalyst and H2O2 as an oxidant to treat simulated p-nitrophenol wastewater under ultraviolet light. The effects of H2O2 dosage, catalyst dosage, initial solution pH value, reaction temperature and reaction time on the removal rate of p-nitrophenol in a photo-assisted heterogeneous Fenton system were determined. According to the relation between the concentration of each component and time, the relation curve is fitted, and then the kinetic equation is established. Finally, we obtained the optimum process conditions to achieve the PNP wastewater removal rate of 98.7%. The degradation of the photo-assisted heterogeneous Fenton method conforms to the first-order kinetic model, and the kinetic equation is . Therefore, photo-assisted heterogeneous Fenton treatment of PNP wastewater is effective and can be used in the treatment of refractory wastewater.