bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Approach for Designing a Novel Recombinant Fusion Protein as a Candidate Vaccine Against HPV
Authors: Sisakht Mohsen , Mahmoodzadeh Amir , Zahedi Mohammadsaeid , Rostamzadeh Davood , Hasan-Abad Amin Moradi , Atapour Amir 
Published: October 2020

Background:
Human Papillomavirus (HPV) is the main biological agent causing Sexually
Transmitted Diseases (STDs), including precancerous lesions and several types of prevalent cancers.
To date, numerous types of vaccines are designed to prevent high-risk HPV. However, their
prophylactic effect is not the same and does not clear previous infections. Therefore, there is an urgent
need for developing therapeutic vaccines that trigger cell-mediated immune responses for the
treatment of HPV. The HPV16 E6 and E7 proteins are ideal targets for vaccine therapy against
HPV. Fusion protein vaccines, which include both immunogenic interest protein and an adjuvant
for augmenting the immunogenicity effects, are theoretically capable of guaranteeing the power of
the immune system against HPV.

Methods:
A vaccine construct, including HPV16 E6/E7 proteins along with a heat shock protein
GP96 (E6/E7-NTGP96 construct), was designed using in silico methods. By the aid of the SWISS--
MODEL server, the optimal 3D model of the designed vaccine was selected, and then the physicochemical
and molecular parameters were performed using bioinformatics tools. Docking studies
were done to evaluate the binding interaction of the vaccine. Allergenicity, immunogenicity, B,
and T cell epitopes of the designed construct were predicted.

Results:
Immunological and structural computational results illustrated that our designed construct
is potentially proper for stimulation of cellular and humoral immune responses against HPV.

Conclusion:
Computational studies showed that the E6/E7-NTGP96 construct is a promising candidate
vaccine that needs further in vitro and in vivo evaluations.
The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart
Authors: Krylatov Andrey , Maslov Leonid , Tsibulnikov Sergey Y. , Voronkov Nikita , Boshchenko Alla , Downey James , Mentzer Robert 
Published: October 2020

:
There is considerable evidence that autophagy in cardiomyocytes is activated by hypoxia/
reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental
model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective)
or deleterious (exacerbate I/R injury). Besides the conundrum as to whether or not autophagy
is an adaptive process, it is clearly regulated by a number of diverse molecules, including
reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The
purpose of this review was to address briefly the controversy regarding the role of autophagy in
this setting and to examine a variety of disparate molecules that are involved in its regulation.
Prevalence and Clinical Profile of Undiagnosed Diabetes Mellitus: Data from a Tertiary Hospital
Authors: Phan Hen H. , Lam Hoang V. , Le Nhan T. , Le Huy N. , Tran Diem T. , Tran An V. , Mai Thao P. , Do Minh D. 
Published: October 2020

Background:
The prevalence of diabetes mellitus in Vietnam is relatively low compared
to other Asian countries, but it is accelerating with the economic and cultural transition. This study
aimed to estimate the current prevalence and clinical profile of undiagnosed diabetes mellitus in a
tertiary hospital in the south of Vietnam.

Methods:
A cross-sectional investigation was conducted to recruit 1, 250 participants, who were at
least 18 year-old and randomly sampled from Cho Ray Hospital, Ho Chi Minh City, Vietnam. Fasting
plasma glucose concentration and HbA1c were measured for each individual. The American Diabetes
Association criteria were used to diagnose diabetes. Demographic data and other clinical
characteristics of diabetes were also documented, including age, sex, residence, educational status,
weight, height, waist and hip circumferences, blood pressure, familial history of diabetes, and lipid
profile.

Results:
The prevalence of undiagnosed diabetes mellitus was 7.5% in the population studied.
Age, waist circumference, waist-hip ratio, body mass index, and hypertension, as well as dyslipidaemia
were well-correlated with the diabetes rate.

Conclusion:
The prevalence of undiagnosed diabetes mellitus is increasing far more than expected.
Newly diagnosed diabetic patients usually presented with multiple comorbidities, including overweight/
obesity, hypertension, and dyslipidaemia.
Bacteriological Quality and Antibiotics' Susceptibility Profile of Small-medium Scale Commercial Fish farms in Nigeria
Authors: Fakorede Cecilia Nireti , Fatokun Evelyn Nwadinkpa , Philip-Kantiok Blessing , Iwu Chinwe Juliana , Jaja Ishmael Festus 
Published: October 2020

Background:
Fish currently provide 6.7% of all proteins consumed by humans globally; nevertheless, the aquaculture system has been linked to fish, environmental contamination and disease outbreak. The aim of this study was to determine the bacteriological quality and the antibiotic resistance profile of bacteria from water samples of pond stocked with Tilapia and Catfish in Ile-Ife, Osun State, Nigeria.

Objective:
To isolate, identify and characterise heterotrophic bacteria and test for the antibiogram of detected Coliforms.

Methods:
Water samples were collected from ponds stocked with Tilapia and Catfish, and tested for total heterotrophic and coliform bacteria as well as the antibiogram. The susceptibility of the isolates was tested using the Kirby-Bauer disc diffusion method on Mueller Hinton agar.

Results:
A total of 40 isolates were recovered from the water samples, of which 5 species were Gram positive bacteria representing two genera, and 35 species were Gram negative bacteria representing four genera. The temperature for all ponds ranged from 25°C to 28°C. The mean bacterial count varied from 1.9×104 to 5.4×104 CFU/ml per fish pond. All isolates were 100% resistant to ceftazidime, cefuroxime and augmentin. More resistance to cefixime (80%) and gentamicin (73.3%) and nitrofurantoin (66.7%) was also recorded. However, only 16.6% and 8.3% of the isolates were resistant to ciprofloxacin and ofloxacin, respectively. The multiple antimicrobial resistance index (MARI) ranged from 0.5 to 0.9. The water physicochemical parameters (temperature and pH) and the type of bacteria detected in all pond types did not differ significantly.

Conclusion:
Fish pond is a reservoir of multi-drug resistant bacteria that could serve as environmental source of drug resistance gene transfer. This calls for effective monitoring and assessment as well as management devices for the protection of community and environmental health.
Engagement Features in Physical Activity Smartphone Apps: Focus Group Study With Sedentary People
Authors: D'Addario Marco , Baretta Dario , Zanatta Francesco , Greco Andrea , Steca Patrizia 
Published: October 2020

Background
Engagement with physical activity mobile apps has been reported to be a core precondition for their effectiveness in digital behavior change interventions. However, to date, little attention has been paid to understanding the perspectives, needs, expectations, and experiences of potential users with physical activity mobile apps.

Objective
The aim of this study was to investigate the features that are judged to be important for engagement with a physical activity mobile app and the reasons for their importance.

Methods
A qualitative focus-group methodology with elements of co-design was adopted in this study. Participants reporting sedentary lifestyles and willingness to improve their physical activity behavior through mobile technology were recruited. The focus group sessions consisted of 13 participants (8 men and 5 women, mean [SD] age 41.9 [7.1] years). Two researchers conducted the data analysis independently by using the inductive thematic approach.

Results
Four main themes emerged in relation to the research question and were named as follows: “physical activity participation motives,” “autonomy and self-regulation,” “need for relatedness,” and “smart.” Additionally, 2 subthemes originated from “physical activity participation motives” (ie, “medical guidance” and “weight loss and fitness for health”) and “smart” (ie, “action planning” and “adaptable and tailored”).

Conclusions
Features enhancing autonomy and self-regulation and positively affecting health and physical well-being as well as the need for relatedness, adaptability, and flexibility should be considered as core elements in the engagement of potential users with physical activity mobile apps. The emerged findings may orient future research and interventions aiming to foster engagement of potential users with physical activity apps.
SUSTAINIBILITY OF INDONESIA TRADEMARK LAW AS UMBRELLA LAW IN RESOLVING DOMAIN NAMES DISPUTE IN INDONESIA
Authors: Ningsih Ayup Suran 
Published: October 2020

AbstractProtection regarding intellectual property in domain names becomes an important thing that must be considered by the domain name’s holder or user. Domain names are by character quite similar to trademarks since they serve as source indicators. This article is written to analyse the Suitability of Indonesia Trademarks Law as Umbrella Law in Resolving Domain Names Dispute in Indonesia. The methodology used in writing this article is normative legal research. Through the comprehensive discussion, it can be concluded that Indonesia trademark law is not suitable to resolve domain name dispute in Indonesia. A domain name is different from a mark based on Indonesia Trademark Law. IntisariPerlindungan terkait kekayaan intelektual dalam nama domain menjadi hal penting yang harus dipertimbangkan oleh pemegang atau pengguna nama domain. Nama domain secara karakter sangat mirip dengan merek dagang karena mereka berfungsi sebagai indikator sumber. Artikel ini bertujuan untuk menganalisis Kesesuaian Hukum Merek Dagang Indonesia sebagai Hukum Payung dalam Menyelesaikan Sengketa Nama Domain di Indonesia. Metodologi yang digunakan dalam penulisan artikel ini adalah penelitian hukum normatif. Melalui pembahasan yang komprehensif dapat disimpulkan bahwa hukum merek dagang Indonesia tidak cocok untuk menyelesaikan perselisihan nama domain di Indonesia. Nama domain berbeda dengan tanda yang diatur pada UU Merek Dagang Indonesia.
Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications
Authors: Poggio Emilio D. , McClelland Robyn L. , Blank Kristina N. , Hansen Spencer , Bansal Shweta , Bomback Andrew S. , Canetta Pietro A. , Khairallah Pascale , Kiryluk Krzysztof , Lecker Stewart H. , McMahon Gearoid M. , Palevsky Paul M. , Parikh Samir , Rosas Sylvia E. , Tuttle Katherine , Vazquez Miguel A. , Vijayan Anitha , Rovin Brad H. ,   for the Kidney Precision Medicine Project
Published: October 2020

Background and objectives
Native kidney biopsies are commonly performed in the diagnosis of acute kidney diseases and CKD. Because of the invasive nature of the procedure, bleeding-related complications are not uncommon. The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases–sponsored Kidney Precision Medicine Project requires that all participants undergo a kidney biopsy; therefore, the objective of this analysis was to study complication rates of native kidney biopsies performed using automated devices under kidney imaging.

Design, setting, participants, & measurements
This is a systematic review and meta-analysis of the literature published from January 1983 to March 2018. The initial PubMed search yielded 1139 manuscripts. Using predetermined selection criteria, 87 manuscripts were included in the final analysis. A random effects meta-analysis for proportions was used to obtain combined estimates of complication rates. Freeman–Tukey double-arcsine transformations were used to stabilize variance as complications were rare.

Results
A total of 118,064 biopsies were included in this study. Patient age ranged from 30 to 79 years, and 45% of patients were women. On the basis of our meta-analysis, pain at the site of biopsy is estimated to occur in 4.3% of biopsied patients, hematomas are estimated to occur in 11%, macroscopic hematuria is estimated to occur in 3.5%, bleeding requiring blood transfusions is estimated to occur in 1.6%, and interventions to stop bleeding are estimated to occur in only 0.3%. Death attributed to native kidney biopsy was a rare event, occurring only in an estimated 0.06% of all biopsies but only 0.03% of outpatient biopsies. Complication rates were higher in hospitalized patients and in those with acute kidney disease. The reported complications varied on the basis of study type and geographic location.

Conclusions
Although the native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Albeit rare, death can occur postbiopsy. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI.
Entrevista pingue-pongue
Authors: Bueno Thaisa Cristina 
Published: October 2020

Este artigo propõe uma catalogação didático-pedagógica de tipos de entrevista pingue-pongue usual no jornalismo escrito nacional com o intuito de sistematizar alguns modelos de textos possíveis e suas variações. A pesquisa vem sanar uma lacuna no debate sobre entrevista escrita, visto que boa parte da literatura que discute o tema na área, em língua portuguesa, dedica-se a tratar, mais pontualmente, das orientações de execução e das condições de produção – Erbolato (1991), Lage (2003), Pereira Júnior (2006), Oyama (2009), Floresta e Brslauskas (2009) e Nascimento (2009), Pinto (2009), Medina (1995) etc. Trata-se de um exercício didático de base descritiva, com amostras por intencionalidade, cujo material do campo foi identificado e captado durante dez semestres (2013, 2014, 2016, 2017 e 2018) em que a pesquisadora atuou como responsável pela disciplina de Gêneros Jornalísticos. A pesquisa também estrutura uma revisão de literatura sobre o assunto.
Despacho económico multiperiodo con restricciones de seguridad usando los factores de sensibilidad PTDF y LODF
Authors: Marin Cristian Camilo , López Lezama Jesús María , Sierra Aguilar Juan Esteban , Jaramillo Duque Alvaro 
Published: October 2020

El problema de despacho económico multiperiodo (DEM) consiste en determinar de manera óptima que unidades de generación deben suministrar potencia al sistema en un horizonte de tiempo típico de 24 horas. El DEM con restricciones de seguridad (SCUC por sus siglas en inglés) es un problema de alto costo computacional debido a la cantidad y naturaleza de las variables involucradas. En este artículo se presenta una formulación alternativa del SCUC para reducir su costo computacional, mediante el uso de los factores de sensibilidad PTDF y LODF. En contraste con las formulaciones clásicas, el uso de estos factores permite calcular flujos de carga sin necesidad de utilizar los ángulos nodales, reduciendo el número de variables y restricciones del modelo. Además, se implementa una metodología de filtro de contingencias activas N-1 que reduce aún más la carga computacional, a través de cortes de usuario. Se presentan resultados para el sistema IEEE-RTS96 que evidencian la robustez y aplicabilidad del modelo propuesto. Se encontró que el uso de los factores de sensibilidad PTDF y LODF, en conjunto con la metodología de filtros de contingencias, reduce el costo computacional hasta en un 86% con respecto a su formulación convencional. Adicionalmente, la metodología propuesta identifica que líneas son más vulnerables debido a sobrecargas, y cuales líneas causan mayores impactos al sistema cuando fallan.
Survey of the security risks of Wi-Fi networks based on the information elements of beacon and probe response frames
Authors: Reyes-Moncayo Hector Ivan , Malaver- Mendoza Luis Daniel , Ochoa-Murillo Andrea Lorena 
Published: October 2020

Wi-Fi networks have become prevalent in homes, businesses, and public places. Wi-Fi is one of the most common means that people use to access digital services like Facebook, WhatsApp, Instagram, email, and even payment platforms. Equipment for deploying Wi-Fi networks is affordable and its basic features are easy to manipulate. In many cases Wi-Fi users do not even have to buy any communication equipment, since Wi-Fi routers are installed by internet service providers (ISP) in the premises of their customers. Wi-Fi equipment, owned either by end users or ISP companies, should be configured as securely as possible to avoid potential attacks. The security capabilities and features of Wi-Fi routers and access points are inserted into beacon and probe response frames. Potential attackers can use sniffing tools like Wireshark to capture these frames and extract information about security features to discover vulnerabilities. In order to assess the security risks of Wi-Fi networks we conducted a survey in which we used Wireshark to capture the traffic from several Wi-Fi networks, and then through a filter we selected the beacon and probe response frames to analyze the security information elements carried by those frames. We came to the conclusion that despite technical recommendations, some security parameters and options are still set in a way that makes networks more prone to attacks. With this paper we want the readers to be aware of the security risks of their Wi-Fi networks, even the ones set up by their internet service providers.
Logística para la respuesta a desastres basada en programas de asistencia social. Caso de Estudio: Riesgo de Terremoto en Bogotá-Colombia
Authors: Rueda Velasco Feizar , Parada Caro Gabriel Darío , López Bello Cesar , Garzón Luna Angélica , Marroquín Ávila Jhonatan 
Published: October 2020

Los programas de asistencia social tienen como propósito brindar apoyo a la población vulnerable o en condiciones de pobreza, algunos de ellos a través de la producción y distribución directa de alimentos. Dada su integración con la población vulnerable, sus capacidades para movilizar carga, la amplia cobertura geográfica y sobre todo su orientación social, dichos programas podrían ser adaptados y preparados para servir como sistema de apoyo ante eventos disruptivos como los desastres naturales. Sin embargo, dicha adaptación hasta ahora no ha sido mencionada en la literatura. Este artículo propone la adaptación de un programa de asistencia social llamado Bienestarina, para la atención de un riesgo de terremoto en la Ciudad de Bogotá-Colombia. Para ello se implementó una metodología de 5 fases, con la cual se identificaron los elementos constitutivos de la cadena de suministro, se determinó un escenario potencial de riesgo de terremoto y el posible efecto del mismo sobre las capacidades de la red. La información obtenida fue el soporte para el diseño de los modelos matemáticos propuestos, a través de los cuales se evaluó un escenario de riesgo con variaciones en los parámetros de capacidades y demandas de asistencia humanitaria, obteniendo así un marco de resultados que permiten entrever la bondad de la integración de este programa en la respuesta a desastres. El aporte principal de la investigación es la evaluación de la integración de las capacidades de los programas de asistencia social para la respuesta a escenarios de desastre, y de manera accesoria la formulación de modelos matemáticos para la planificación de la respuesta considerando la vulnerabilidad de la infraestructura y el uso de concepto de “Zonas seguras” para la localización de instalaciones.
Modeling Vibration-Induced Tire-Pavement Interaction Noise in the Mid-frequency Range
Authors: McBride Sterling , Burdisso Ricardo , Sandu Corina 
Published: October 2020

ABSTRACT
Tire-pavement interaction noise (TPIN) is one of the main sources of exterior noise produced by vehicles traveling at greater than 50 kph. The dominant frequency content is typically within 500–1500 Hz. Structural tire vibrations are among the principal TPIN mechanisms. In this work, the structure of the tire is modeled and a new wave propagation solution to find its response is proposed. Multiple physical effects are accounted for in the formulation. In an effort to analyze the effects of curvature, a flat plate and a cylindrical shell model are presented. Orthotropic and nonuniform structural properties along the tire's transversal direction are included to account for differences between its sidewalls and belt. Finally, the effects of rotation and inflation pressure are also included in the formulation. Modeled frequency response functions are analyzed and validated. In addition, a new frequency-domain formulation is presented for the computation of input tread pattern contact forces. Finally, the rolling tire's normal surface velocity response is coupled with a boundary element model to demonstrate the radiated noise at the leading and trailing edge locations. These results are then compared with experimental data measured with an on-board sound intensity system.
HUBUNGAN ANTARA PENGELOLAAN LINGKUNGAN BELAJAR DENGAN HASIL BELAJAR PESERTA TAHFIZD DI TPQ-TPSQ AL-HASIB BERINGIN NAGARI LANSAT KADAP KECAMATAN RAO SELATAN KABUPATEN PASAMAN
Authors: Gustria Nela 
Published: October 2020

ABSTRACT This research is motivated by the low learning outcomes of tahfizd participants in the Al-Hasib Banyan Al-Hasib TPQ-TPSQ allegedly due to the lack of management of the learning environment in Al-Hasib Nagari TPQ-TPSQ Lansat Kadap, Rao Selatan District, Pasaman Regency. This study aims to: (1) describe the management of the learning environment, (2) describe the learning outcomes of participants, and (3) see the relationship between the management of the learning environment and the learning outcomes of tahfizd participants at TPQ / TPSQ Al-Hasib in Beringin. This study is classified as correlational quantitative with a population of all TPQ and TPSQ participants consisting of elementary school children in grades V and VI and junior classes I, II, III with 28 people. While the sample was taken as much as 75% of the population, amounting to 21 people with stratified random sampling technique. Data collection techniques using structured interviews and then analyzed using descriptive analysis and the rhank order correlation formula. The results showed that: (1) the management of learning environment in TPQ-TPSQ Al-Hasib was categorized as still not good, (2) the learning outcomes of tahfizd participants in TPQ-TPSQ Al-Hasib Banyan were relatively low, and (3) there was a significant relationship between management of the learning environment with the learning outcomes of tahfizd participants at the TPQ / TPSQ Al-Hasib Banyan Nagari Lansat Kadap Kecamatan Rao Selatan Pasaman RegencyKeywords: environmental management, learning outcomes