bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities
Authors: Williams Nia , Radia Trisha , Harman Katharine , Agrawal Pankaj , Cook James , Gupta Atul 
Published: September 2020

AbstractData show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and death. The study protocol was in keeping with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A total of 1726 articles were identified of which 28 studies fulfilled the inclusion criteria. The 28 studies included 5686 participants with confirmed SARS-CoV-2 infection ranging from mild to severe disease. We focused on the 108 patients who suffered from severe/critical illness requiring ventilation, which included 17 deaths. Of the 108 children who were ventilated, the medical history was available for 48 patients. Thirty-six of the 48 patients (75%) had documented comorbidities of which 11/48 (23%) had pre-existing cardiac disease. Of the 17 patients who died, the past medical history was reported in 12 cases. Of those, 8/12 (75%) had comorbidities.Conclusion: Whilst only a small number of children suffer from COVID-19 disease compared to adults, children with comorbidities, particularly pre-existing cardiac conditions, represent a large proportion of those that became critically unwell.

What is Known:• Children are less severely affected by SARS-CoV-2 than adults.• There are reports of children becoming critically unwell with SARS-CoV-2 and requiring intensive care.

What is New:• The majority of children who required ventilation for SARS-CoV-2 infection had underlying comorbidities.• The commonest category of comorbidity in these patients was underlying cardiac disease.
Randomized Incremental Construction of Delaunay Triangulations of Nice Point Sets
Authors: Boissonnat Jean-Daniel , Devillers Olivier , Dutta Kunal , Glisse Marc 
Published: September 2020

AbstractRandomized incremental construction (RIC) is one of the most important paradigms for building geometric data structures. Clarkson and Shor developed a general theory that led to numerous algorithms which are both simple and efficient in theory and in practice. Randomized incremental constructions are usually space-optimal and time-optimal in the worst case, as exemplified by the construction of convex hulls, Delaunay triangulations, and arrangements of line segments. However, the worst-case scenario occurs rarely in practice and we would like to understand how RIC behaves when the input is nice in the sense that the associated output is significantly smaller than in the worst case. For example, it is known that the Delaunay triangulation of nicely distributed points in $${\mathbb {E}}^d$$

E

d

or on polyhedral surfaces in $${\mathbb {E}}^3$$

E

3

has linear complexity, as opposed to a worst-case complexity of $$\Theta (n^{\lfloor d/2\rfloor })$$

Θ
(

n

⌊
d
/
2
⌋

)

in the first case and quadratic in the second. The standard analysis does not provide accurate bounds on the complexity of such cases and we aim at establishing such bounds in this paper. More precisely, we will show that, in the two cases above and variants of them, the complexity of the usual RIC is $$O(n\log n)$$

O
(
n
log
n
)

, which is optimal. In other words, without any modification, RIC nicely adapts to good cases of practical value. At the heart of our proof is a bound on the complexity of the Delaunay triangulation of random subsets of $${\varepsilon }$$
ε
-nets. Along the way, we prove a probabilistic lemma for sampling without replacement, which may be of independent interest.
Surprise at Adjoining an Identity to an Algebra
Authors: Andruszkiewicz Ryszard R. 
Published: September 2020

AbstractThis note contains an example of two non-isomorphic algebras A and B over an arbitrary field K such that the algebras $\widetilde {A}$

A

~

and $\widetilde {B}$

B

~

obtained form A and B, respectively, by the standard process of adjoining an identity, are isomorphic. In addition, the dimension of A may be arbitrary ≥ 2.
Anomaly detection in facial skin temperature using variational autoencoder
Authors: Masaki Ayaka , Nagumo Kent , Lamsal Bikash , Oiwa Kosuke , Nozawa Akio 
Published: September 2020

AbstractFacial skin temperature is a physiological index that varies with skin blood flow controlled by autonomic nervous system activity. The facial skin temperature can be remotely measured using infrared thermography, and it has recently attracted attention as a remote biomarker. For example, studies have been reported to estimate human emotions, drowsiness, and mental stress on facial skin temperature. However, it is impossible to make a machine that can discriminate all infinite physiological and psychological states. Considering the practicality of skin temperature, a machine that can determine the normal state of facial skin temperature may be sufficient. In this study, we propose a completely new approach to incorporate the concept of anomaly detection into the analysis of physiological and psychological states by facial skin temperature. In this paper, the method for separating normal and anomaly facial thermal images using an anomaly detection model was investigated to evaluate the applicability of variational autoencoder (VAE) to facial thermal images.
Revision by S2-alar-iliac instrumentation reduces caudal screw loosening while improving sacroiliac joint pain—a group comparison study
Authors: Krieg Sandro M. , Sollmann Nico , Ille Sebastian , Albers Lucia , Meyer Bernhard 
Published: September 2020

AbstractLumbosacral instrumentation continues to be challenging due to complex biomechanical force distributions and poor sacral bone quality. Various techniques have therefore been established. The aim of this study was to investigate the outcome of patients treated with S2-alar-iliac (S2AI), S2-alar (S2A), and iliac (I) instrumentation as the most caudal level. Sixty patients underwent one of the 3 techniques between January 2012 and June 2017 (S2AI 18 patients, S2A 20 patients, I 22 patients). Mean age was 70.4 ± 8.5 years. Screw loosening (SL) and sacroiliac joint (SIJ) pain were evaluated during the course at 3-month and maximum follow-up (FU). All patients completed 3-month FU, the mean FU period was 2.5 ± 1.5 years (p = 0.38), and a median of 5 segments was operated on (p = 0.26), respectively. Bone mineral density (BMD), derived opportunistically from computed tomography (CT), did not significantly differ between the groups (p = 0.66), but cages were more frequently implanted in patients of the S2A group (p = 0.04). SL of sacral or iliac screws was more common in patients of the S2A and I groups compared with the S2AI group (S2AI 16.7%, S2A 55.0%, I 27.3% of patients; p = 0.03). SIJ pain was more often improved in the S2AI group not only after 3 months but also at maximum FU (S2AI 61.1%, S2A 25.0%, I 22.7% of patients showing improvement; p = 0.02). Even in shorter or mid-length lumbar or thoracolumbar constructs, S2AI might be considered superior to S2A and I instrumentation due to showing lower incidences of caudal SL and SIJ pain.
Improving ADMMs for solving doubly nonnegative programs through dual factorization
Authors: Cerulli Martina , De Santis Marianna , Gaar Elisabeth , Wiegele Angelika 
Published: September 2020

AbstractAlternating direction methods of multipliers (ADMMs) are popular approaches to handle large scale semidefinite programs that gained attention during the past decade. In this paper, we focus on solving doubly nonnegative programs (DNN), which are semidefinite programs where the elements of the matrix variable are constrained to be nonnegative. Starting from two algorithms already proposed in the literature on conic programming, we introduce two new ADMMs by employing a factorization of the dual variable. It is well known that first order methods are not suitable to compute high precision optimal solutions, however an optimal solution of moderate precision often suffices to get high quality lower bounds on the primal optimal objective function value. We present methods to obtain such bounds by either perturbing the dual objective function value or by constructing a dual feasible solution from a dual approximate optimal solution. Both procedures can be used as a post-processing phase in our ADMMs. Numerical results for DNNs that are relaxations of the stable set problem are presented. They show the impact of using the factorization of the dual variable in order to improve the progress towards the optimal solution within an iteration of the ADMM. This decreases the number of iterations as well as the CPU time to solve the DNN to a given precision. The experiments also demonstrate that within a computationally cheap post-processing, we can compute bounds that are close to the optimal value even if the DNN was solved to moderate precision only. This makes ADMMs applicable also within a branch-and-bound algorithm.
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR
Authors: Marco-Rius Irene , Wright Alan J. , Hu De-en , Savic Dragana , Miller Jack J. , Timm Kerstin N. , Tyler Damian , Brindle Kevin M. , Comment Arnaud 
Published: September 2020

Abstract
Objectives
To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate to follow gluconeogenesis, glycolysis and the glycerol pathways. However, the use of [2-13C]DHAc in vivo has not taken off because (i) the chemical shift range of [2-13C]DHAc and its metabolic products span over 144 ppm, and (ii) 1H decoupling is required to increase spectral resolution and sensitivity. While these issues are trivial for high-field vertical-bore NMR spectrometers, horizontal-bore small-animal MR scanners are seldom equipped for such experiments.

Methods
Real-time hepatic metabolism of three fed mice was probed by 1H-decoupled 13C-MR following injection of hyperpolarized [2-13C]DHAc. The spectra of [2-13C]DHAc and its metabolic products were acquired in a 7 T small-animal MR scanner using three purpose-designed spectral-spatial radiofrequency pulses that excited a spatial bandwidth of 8 mm with varying spectral bandwidths and central frequencies (chemical shifts).

Results
The metabolic products detected in vivo include glycerol 3-phosphate, glycerol, phosphoenolpyruvate, lactate, alanine, glyceraldehyde 3-phosphate and glucose 6-phosphate. The metabolite-to-substrate ratios were comparable to those reported previously in perfused liver.

Discussion
Three metabolic pathways can be probed simultaneously in the mouse liver in vivo, in real time, using hyperpolarized DHAc.
The “critical view of safety (CVS)” cannot be applied—What to do? Strategies to avoid bile duct injuries
Authors: Mischinger Hans-Jörg , Wagner Doris , Kornprat Peter , Bacher Heinz , Werkgartner Georg 
Published: September 2020

SummaryLaparoscopic cholecystectomy has become the standard procedure worldwide since the early 1990s for those patients whose gallbladder has to be removed as part of their underlying disease (NIH Consensus Statement 1992). The most common complication is iatrogenic bile duct injury, which has not improved significantly since the introduction of open laparoscopic cholecystectomy as compared with open cholecystectomy. The intraoperative injuries are mostly the result of a misinterpretation of anatomical structures due to severe inflammation or topographical variations. In order to minimize this risk, a number of improved operative techniques and behavioral measures have been formulated. Here, we present methodological and operative possibilities as well as techniques that in unclear situations can help to minimize the risk of intraoperative injuries of the biliary tract and the accompanying vascular system.
An Interactive Layers Model of Self-Regulated Learning and Cognitive Load
Authors: Wirth Joachim , Stebner Ferdinand , Trypke Melanie , Schuster Corinna , Leutner Detlev 
Published: September 2020

AbstractModels of self-regulated learning emphasize the active and intentional role of learners and, thereby, focus mainly on conscious processes in working memory and long-term memory. Cognitive load theory supports this view on learning. As a result, both fields of research ignore the potential role of unconscious processes for learning. In this review paper, we propose an interactive layers model on self-regulated learning and cognitive load that considers sensory memory, working memory, and long-term memory. The model distinguishes between (a) unconscious self-regulated learning initiated by so-called resonant states in sensory memory and (b) conscious self-regulated learning of scheme construction in working memory. In contrast with conscious self-regulation, unconscious self-regulation induces no cognitive load. The model describes conscious and unconscious self-regulation in three different layers: a content layer, a learning strategy layer, and a metacognitive layer. Interactions of the three layers reflect processes of monitoring and control. We first substantiate the model based on a narrative review. Afterwards, we illustrate how the model contributes to re-interpretation of inconsistent empirical findings reported in the existing literature.
Extreme value theory for anomaly detection – the GPD classifier
Authors: Vignotto Edoardo , Engelke Sebastian 
Published: September 2020

AbstractClassification tasks usually assume that all possible classes are present during the training phase. This is restrictive if the algorithm is used over a long time and possibly encounters samples from unknown new classes. It is therefore fundamental to develop algorithms able to distinguish between normal and abnormal test data. In the last few years, extreme value theory has become an important tool in multivariate statistics and machine learning. The recently introduced extreme value machine, a classifier motivated by extreme value theory, addresses this problem and achieves competitive performance in specific cases. We show that this algorithm has some theoretical and practical drawbacks and can fail even if the recognition task is fairly simple. To overcome these limitations, we propose two new algorithms for anomaly detection relying on approximations from extreme value theory that are more robust in such cases. We exploit the intuition that test points that are extremely far from the training classes are more likely to be abnormal objects. We derive asymptotic results motivated by univariate extreme value theory that make this intuition precise. We show the effectiveness of our classifiers in simulations and on real data sets.
A Tool for Comparing Mathematics Tasks from Paper-Based and Digital Environments
Authors: Lemmo Alice 
Published: September 2020

AbstractComparative studies on paper and pencil– and computer-based tests principally focus on statistical analysis of students’ performances. In educational assessment, comparing students’ performance (in terms of right or wrong results) does not imply a comparison of problem-solving processes followed by students. In this paper, we present a theoretical tool for task analysis that allows us to highlight how students’ problem-solving processes could change in switching from paper to computer format and how these changes could be affected by the use of one environment rather than another. In particular, the aim of our study lies in identifying a set of indexes to highlight possible consequences that specific changes in task formulation have, in terms of task comparability. Therefore, we propose an example of the use of the tool for comparing paper-based and computer-based tasks.
Diel vertical migration promotes zooplankton horizontal patchiness
Authors: Chen Bingzhang , Masunaga Eiji , Smith Sherwood Lan , Yamazaki Hidekatsu 
Published: September 2020

AbstractSpatial patchiness of plankton enhances fishery production and carbon export in the ocean. While diel vertical migration (DVM) has been identified as an important factor contributing to vertical patchiness, its effect on horizontal patchiness has never been investigated. We use a simple individual-based zooplankton model to examine the effect of DVM on the horizontal patchiness of four zooplankton groups with differing DVM patterns in a two-dimensional ocean circulation model. We find that zooplankton horizontal patchiness can be induced by two mechanisms: (1) in stratified waters, DVM can synchronize zooplankton vertical positions with the horizontal current velocities that drive them, resulting in horizontal patchiness; and (2) migrating zooplankton tend to aggregate in deep waters when they encounter sea bottom. Due to these mechanisms, zooplankton horizontal patchiness may be ubiquitous in the ocean, enhancing secondary production and fisheries.
Student-Generated Stop-Motion Animation in Science Classes: a Systematic Literature Review
Authors: Farrokhnia Mohammadreza , Meulenbroeks Ralph F. G. , van Joolingen Wouter R. 
Published: September 2020

AbstractIn recent years, student-generated stop-motion animations (SMAs) have been employed to support sharing, constructing, and representing knowledge in different science domains and across age groups from pre-school to university students. The purpose of this review is to give an overview of research in this field and to synthesize the findings. For this review, 42 publications on student-generated SMA dating from 2005 to 2019 were studied. The publications were systematically categorized on learning outcomes, learning processes, learning environment, and student prerequisites. Most studies were of a qualitative nature, and a significant portion (24 out of 42) pertained to student teachers. The findings show that SMA can promote deep learning if appropriate scaffolding is provided, for example, in terms of presenting general strategies, asking questions, and using expert representations. Also, the science concept that is to be presented as a SMA should be self-contained, dynamic in nature, and not too difficult to represent. Comparative quantitative studies are needed in order to judge the effectiveness of SMA in terms of both cognitive and non-cognitive learning outcomes.
The development and validation of the CARe Burn Scale: Child Form: a parent-proxy-reported outcome measure assessing quality of life for children aged 8 years and under living with a burn injury
Authors: Griffiths Catrin , Guest Ella , Pickles Timothy , Hollèn Linda , Grzeda Mariusz , Tollow Philippa , Harcourt Diana 
Published: September 2020

Abstract
Purpose
Patient-reported outcome measures (PROMs) identify patient needs and therapeutic progress. This paper outlines the development and validation of the CARe Burn Scale: Child Form, a parent-proxy-reported outcome measure that assesses quality of life in children aged 8 and under living with a burn injury.

Methods
A literature review and interviews with 12 parents of children with a burn and seven health professionals informed the development of a conceptual framework and draft PROM. Cognitive debriefing interviews with 18 parents and eight health professionals provided feedback to ascertain content validity, and 311 parents took part in field testing. Rasch and traditional psychometric analyses were conducted to create a shortened version. Further psychometric analyses with 133 parents tested the shortened CARe Burn Scale in relation to other parent-proxy measures.

Results
The final conceptual framework included 5 domains: Social and Emotional Difficulties, Social and Emotional Well-Being, Wound/Scar Discomfort, Wound/Scar Treatment and Physical Abilities. Two scales fulfilled Rasch and traditional psychometric analyses, providing evidence of construct validity, acceptability, and reliability. Three scales did not fulfil the Rasch criteria and were retained as checklists. Compared to other parent-proxy measures, individual CARe Burn Scales correlated moderately with similar constructs and had low correlations with dissimilar constructs, indicating evidence of criterion validity (concurrent and discriminant).

Conclusions
The CARe Burn Scale: Child Form can be used to measure children’s quality of life after having a burn injury which can inform rehabilitation and surgical decision-making.
The Actis and Corail Femoral Stems Provide for Similar Clinical and Radiographic Outcomes in Total Hip Arthroplasty
Authors: Kaszuba Stephanie V. , Cipparrone Nancy , Gordon Alexander C. 
Published: September 2020

Background The introduction of new devices for total hip arthroplasty (THA) offers surgeons the ability to address deficits in the portfolio. However, once introduced, data regarding the performance of devices is not publicly available until their use is widespread. Purpose/Questions The objective of this study was to compare the clinical and radiographic performance, including patient reported outcomes and radiographic evidence of osseointegration, subsidence, and stress shielding, of the newer Actis femoral component to the Corail stem (DePuy Synthes, Warsaw, IN, USA), which has an extensive clinical history. Methods This short-term, retrospective cohort study was a single surgeon series of 330 anterior approach THAs, consisting of 165 cases using the Actis stem and 165 cases using the Corail stem. Both devices were cementless, titanium, tapered, hydroxyapatite–coated stems. They differed in geometry, neck choices, broach philosophy, and collar availability. Data was obtained for 1 year following THA. Functional outcomes were measured with the Hip Dysfunction and Osteoarthritis Outcome Score for Joint Replacement (HOOS, JR.) survey. Complications were recorded from patient charts, and radiographic analysis was performed for signs of osseointegration, subsidence, and stress shielding. Results The groups shared similar demographic characteristics except the Actis population was younger with fewer women. The complication rate did not significantly vary, and no patient required revision within the first year. Radiographically, one patient in each group demonstrated subsidence. No cases exhibited radiolucent lines, and the prevalence of stress shielding at 1 year was comparable. HOOS, JR. scores did not significantly vary at 8 weeks or 1 year. Conclusion The Actis stem does not carry an increased risk of device-related complications compared with the Corail implant. Although aspects of bone remodeling differed between groups, Actis achieved radiographic signs of bone ingrowth at the 1-year mark and performed well clinically, with equivalent patient reported outcome scores to the Corail stem.