bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indocyanine green videoangiography for recipient vessel stratification in superficial temporal artery–middle cerebral artery bypass surgery
Authors: Goldberg Johannes , Vajkoczy Peter , Hecht Nils 
Published: August 2020

OBJECTIVE
In superficial temporal artery–middle cerebral artery (STA-MCA) bypass surgery, recipient vessel properties are likely one of the main reasons for bypass failure. In daily practice, most surgeons select the recipient with the largest diameter. However, selection of the ideal recipient remains debatable because there are no objective selection criteria if multiple potential recipients exist. Here, the authors assessed the benefit of using indocyanine green videoangiography (ICG-VA) to optimize recipient vessel selection in patients undergoing STA-MCA bypass surgery for hemodynamic compromise.

METHODS
All patients who had undergone STA-MCA bypass procedures with pre- and postanastomosis ICG-VA between 2010 and 2019 were eligible for inclusion in this study. The primary bypass surgeon was blinded to the preanastomosis ICG-VA. Preanastomosis white-light and ICG-VA images were compared to determine the identifiability of potential recipient vessels and pathological flow patterns. After completion of the anastomosis, a second (postanastomosis) ICG-VA image was used to analyze the flow increase within the chosen recipient based on the vessel diameter, initial recipient blood flow, initial sequence of appearance on ICG-VA, initial blood flow direction within the recipient, and orientation of the bypass graft. ICG-VA, FLOW 800, and intraoperative white-light images, as well as demographic, clinical, and radiographic patient data, were retrospectively analyzed by a clinician who was not directly involved in the patients’ care.

RESULTS
Sixty patients underwent 65 STA-MCA bypass procedures with pre- and postanastomosis ICG-VA. The ICG-VA permitted identification of a significantly higher number of potential recipient vessels (median 4, range 1–9) than the white-light images (median 2, range 1–5; p < 0.001), with detection of pathological flow patterns in 20% of all procedures. No association was found between the diameter and blood flow within potential recipients (Spearman r = 0.07, p = 0.69). After bypass grafting, the highest flow increase was noted in recipients with an initially low flow (p < 0.01), a late appearance (p < 0.01), and an initially retrograde flow direction (p = 0.02). Interestingly, flow increase was not significantly influenced by the recipient diameter (p = 0.09) or graft orientation (p = 0.44).

CONCLUSIONS
ICG-VA facilitates identification of potential recipient vessels and detection of pathological flow patterns. Recipients with an initially low flow, a late appearance, and a retrograde flow seem to bear the highest potential for flow increase, possibly due to a higher hemodynamic need for revascularization.
An analysis of preoperative shoulder and neck balance and surgical outcome in 111 adolescent idiopathic scoliosis patients with two subtypes of Lenke 1 curves
Authors: Wei Chan Chris Yin , Chiu Chee Kidd , Ng Yun Hui , Goh Saw Huan , Ler Xin Yi , Ng Sherwin Johan , Chian Xue Han , Tan Pheng Hian , Kwan Mun Keong 
Published: August 2020

OBJECTIVEThe incidence of postoperative shoulder imbalance following posterior spinal fusion (PSF) is still high in Lenke 1 curves despite following current treatment recommendations for upper instrumented vertebra (UIV) selection. The objective of this retrospective study was to identify differences in preoperative shoulder balance and to report the surgical outcome of two subtypes of Lenke 1 curves (flexible vs stiff) in patients with adolescent idiopathic scoliosis (AIS).METHODSThe authors grouped patients’ curves as Lenke 1–ve (flexible) when their preoperative proximal thoracic side bending (PTSB) Cobb angle was < 15° and as Lenke 1+ve (stiff) when the PTSB Cobb angle was 15°–24.9°. The authors hypothesized that these two subtypes had distinct preoperative and postoperative shoulder and neck balance following PSF using pedicle screw constructs.RESULTSFifty patients had Lenke 1 (flexible) curves and 61 had Lenke 1 (stiff) curves. The mean preoperative T1 tilt for patients with Lenke 1 (flexible) was −4.9° ± 5.3°, and for those with Lenke 1 (stiff) curves it was −1.0° ± 5.3° (p < 0.001). Mean cervical axis (CA) was −0.1° ± 3.2° for Lenke 1 (flexible) curves and 2.3° ± 3.5° for Lenke 1 (stiff) curves (p < 0.001). Preoperative radiographic shoulder height (RSH) and clavicle angle (Cla-A) were similar between the two curve subtypes. Following surgery, there were significant differences between the subtypes in terms of T1 tilt (p < 0.001), RSH (p = 0.014), and Cla-A (p = 0.031). Interestingly, 41.0% of patients with a Lenke 1 (stiff) curve had +ve T1 tilt compared to 2.0% in Lenke 1 (flexible) group. Moreover, 26.2% of patients with the Lenke 1 (stiff) curve had +ve RSH compared to 12.0% of those with Lenke 1 (flexible) curves. And, 24.6% of patients with Lenke 1 (stiff) had +ve Cla-A compared to 10.0% of those with Lenke 1 (flexible) curves.CONCLUSIONSLenke 1 (flexible) and Lenke 1 (stiff) curves had distinct preoperative T1 tilt and CA measurements. Following PSF, the authors noted +ve T1 tilt in 41% of patients with Lenke 1 (stiff) curves versus 2.0% in those with Lenke 1 (flexible) curves. The authors also noted a significant difference in postoperative RSH and Cla-A measurements.
Effect of Salam leaf extract (Syzygium Polyanthum) to serum IL-10 levels on Acute Coronary Syndrome in Wistar Strain Mice Model
Authors: Tanjung Yulisa Astari , Refli Hasan  , Rahmad Isnanta  
Published: August 2020

Background Coronary Heart Disease (CHD) is one of the leading causes of death in developed and developing countries. Syzygium polyanthum leaf (daun salam) are reported to have anti-inflammatory, antioxidant, antidiabetic, antimicrobial, antihypertensive, antitumor, antidiarrheal, acetylcholinesterase inhibition, and lipase inhibitory activity. The purpose of this study was to prove the effect of bay leaf extract (Syzygium polyanthum) on serum interleukin (IL)-10 levels in the heart of Wistar Strain Mice Model of Acute Coronary Syndrome (ACS). Methods This is an experimental study to compare the IL-10 level in 32 ACS mice which were divided into 8 groups. Serum IL-10 values were collected and analyzed according to the corresponding group with and without bay leaf extract administration, on day 1,4,7, and 14. Result: There is an IL-10 value increasing with the duration of examination following the onset of ACS induction. The highest average IL-10 value was found on the 14th day, in the two groups. On the same day, it was seen that the treatment group had a higher IL-10 value compared to the control group (p<0.001). The result showed that the concentration of IL-10 was significantly greater among the treatment group, which reveal the potential benefit of bay leaf extract in patients with ACS. Conclusion: There was found a significant difference of serum IL-10 between Wistar Strain Mice Model of ACS that was given S. polyanthum leaf extracts. S. polyanthum leaf extract has quite extensive benefits in the cardiovascular system.
Correlation of Body Mass Index and Kellgren-Lawrence Degrees in Genu Osteoarthritis
Authors: Hardiyanti Vien , Devi Mariane , Setiawan I Made Buddy , Wungou Herman P. L. 
Published: August 2020

Background: Obesity is a major risk factor for osteoarthritis.
Objectives: The aim of this study is to determine the correlation between body mass index with Kellgren-Lawrence degree in genu osteoarthritis patients.
Methods: This study used cross-sectional design on 97 participants diagnosed with genu osteoarthritis in Siloam Hospital Kupang in the period January-December 2017. Measurement of height and weight was carried out for the calculation of Body Mass Index. Kellgren-Lawrence degrees were obtained with x-ray photos.
Results: Most patients were women (69 patients, 71.7%), 50-59 years old (34 patients, 35.1%), with obesity (61 patients, 62.9%).
Conclusion: There was a significant correlation between BMI and Kellgren-Lawrence degree in genu osteoarthritis (p = 0.000).
Keywords: BMI, Kellgren-Lawrence, obesity, osteoarthritis genu

Latar Belakang: Obesitas merupakan faktor risiko terjadinya osteoartritis pada lutut.
Tujuan: Tujuan dari penelitian ini adalah untuk menentukan korelasi indeks massa tubuh (IMT) dengan derajat Kellgren-Lawrence pada pasien penderita osteoartritis genu.
Metode: Penelitian ini menggunakan metode cross-sectional yang dilakukan pada 97 responden yang didiagnosis dengan osteoartritis lutut di Rumah Sakit Siloam Kupang pada periode Januari-Desember 2017. Derajat Kellgren-Lawrence ditentukan berdasarkan foto x-ray konvensional.
Hasil: Penderita osteoartritis terbanyak adalah perempuan (69 pasien, 71,7%), berusia antara 50-59 tahun (34 pasien, 35,1%), dan dengan IMT kategori obesitas (61 pasien, 62,9%).
Kesimpulan: Terdapat korelasi signifikan antara IMT dan derajat Kellgren-Lawrence pada penderita osteoartritis genu. (p = 0,000).
Kata kunci: IMT, Kellgren-Lawrence, obesitas, osteoartritis genu
Tingkat Pengetahuan, Sikap, dan Perilaku Remaja tentang Kesehatan Reproduksi di SMK Negeri 8 Medan
Authors: Nasution Iqbal Pahlevi Adeputra , Manik Binsyah Sari Indah Gajah 
Published: August 2020

Background: Reproductive health is one of the most important things for human life, which includes a complete physical, mental, social welfare condition in all matters relating to the function and role of the reproductive system. Reproductive health education should be given since adolescence, because adolescence is a phase towards more mature reproduction. Adolescent problems related to reproductive health, often stem from a lack of information, understanding and awareness to achieve reproductive health.
Objectives: This study aims to determine the level of knowledge, attitudes and behavior of adolescents about reproductive health at SMK Negeri 8 Medan.
Methods: This study was a descriptive study with a cross sectional design. The research data is primary data, namely by filling out a questionnaire. The sample of this research is 96 people. The sample technique is stratified random sampling. Data were analyzed using the SPSS computer program using descriptive statistical tests and displaying the results in distribution and frequency tables.
Results: Knowledge level of adolescents in SMK Negeri 8 Medan is good (59.4%), attitude level is good (80.2%) and behavior level is good (99%).
Conclusion: The level of knowledge, attitudes and behavior of adolescents about health reproduction at SMK Negeri 8 is classified as good.
Keywords: adolescent, attitude, behavior, knowledge, reproductive health

Latar Belakang: Kesehatan reproduksi merupakan salah satu hal yang sangat penting bagi kehidupan manusia yaitu mencakup keadaan sejahtera baik fisik, mental, sosial yang utuh dalam segala hal yang berkaitan dengan fungsi, peran dari sistem reproduksi. Pendidikan kesehatan reproduksi sebaiknya diberikan sejak remaja, karena remaja merupakan fase menuju reproduksi yang lebih matang. Permasalahan remaja yang berkaitan dengan kesehatan reproduksi, sering kali berakar dari kurangnya informasi, pemahaman dan kesadaran untuk mencapai keadaan sehat secara reproduksi.
Tujuan: Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan, sikap dan perilaku remaja tentang kesehatan reproduksi di SMK Negeri 8 Medan.
Metode: Penelitian ini adalah studi deskriptif dengan desain cross sectional. Data penelitian adalah data primer yaitu dengan pengisian kuesioner. Sampel penelitian ini berjumlah 96 orang. Teknik sampel adalah stratified random sampling. Data dianalisis menggunakan program komputer SPSS menggunakan uji statistik deskriptif dan menampilkan hasil dalam tabel distribusi dan frekuensi.
Hasil: Tingkat pengetahuan remaja SMK Negeri 8 Medan tergolong baik (59,4%), tingkat sikap tergolong baik (80,2%), dan tingkat perilaku tergolong baik (99%).
Kesimpulan: Tingkat pengetahuan, sikap dan perilaku remaja tentang kesehatan reproduksi di SMK Negeri 8 tergolong baik.
Kata kunci: kesehatan reproduksi, pengetahuan, perilaku, remaja, sikap
Contratos con referencias a competidores (CRC): referencias contractuales a tereceros y restricciones a la competencia
Authors: Marcos Fernández Francisco 
Published: August 2020

Este artículo examina la problemática jurídica y las razones económicas que subyacen a las cláusulas contractuales con referencias a terceros, en particular, las que aluden a competidores o rivales de las partes contratantes para regular distintos aspectos de la relación contractual, principalmente el precio. La utilización de este tipo de cláusulas se ha multiplicado con el desarrollo de los mercados plataforma y el comercio digital en internet.
META-ANALYSIS : COMPARISON OF NEOVAGINA SUCCESS RATE WITH VECCHIETTI'S LAPAROSCOPIC METHOD AND DAVYDOV'S LAPAROSCOPIC METHOD IN MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME (MRKH) PATIENTS
Authors: Prionggo Yanuar , Kurniawati Eighty Mardiyan 
Published: August 2020

ABSTRACT

Background
Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is caused by an embryological growth disorder of the mullerian duct. Laparoscopic Vecchietti and Davydov are laparoscopic surgery techniques that are often used for neovaginal surgery

Objective
This paper aims to compare the success rate of neovagina with the Vecchietti laparoscopic method and Davydov's laparoscopic method in patients with Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH)

Methods: A systematic data search was performed on a medical database (PUBMED, MEDLINE, Cochrane Database, Google Scholar). Inclusion criteria: (1) randomized randomized study of the Vecchietti Laparoscopic Method with Davydov’s Laparoscopy, (2) all inclusive papers can be accessed completely, and (3) the data obtained can be accurately analyzed

Data acquisition and analysis: We searched for a random blind study (RCT) with the following keywords: (1) Vecchietti Laparoscopy [title] AND (2) Davydov’s Laparoscopy [title] AND Mayer-Rokitansky-Kuster-Hauser syndrome [title]

Results: Three RCTs comparing neovaginal success with the Vecchietti laparoscopic method and Davydov's laparoscopic method a total of 122 patients were analyzed. Average vaginal length (mean difference [MD] -0.70, and 95% [CI] -0.99 to -0.41 (P <0.00001), Average number of Female Sexual Function Index scores (mean difference [MD] -1.34, and 95% [CI] -1.71 through -0.96. (P <0.00001)

Conclusion
This meta-analysis concludes that Davydov’s Laparoscopic Method is better in terms of postoperative vaginal length and the Female Sexual Function Index Score

Keywords
Mayer-Rokitansky-Kuster-Hauser Syndrome,Laparoscopic Davydov,Laparoscopic Vecchietti,Vaginal Length,FSFI Score
Editor’s Pick: Regulatory and Ethical Issues in the New Era of Radiomics and Radiogenomics
Authors: Pesapane Filippo 
Published: August 2020

Radiomics is a science that investigates a large number of features from medical images using data-characterisation algorithms, with the aim to analyse disease characteristics that are indistinguishable to the naked eye. Radiogenomics attempts to establish and examine the relationship between tumour genomic characteristics and their radiologic appearance. Although there is certainly a lot to learn from these relationships, one could ask the question: what is the practical significance of radiogenomic discoveries? This increasing interest in such applications inevitably raises numerous legal and ethical questions. In an environment such as the technology field, which changes quickly and unpredictably, regulations need to be timely in order to be relevant. In this paper, issues that must be solved to make the future applications of this innovative technology safe and useful are analysed.
Analisis Perilaku Non Playable Character (Npc) Pada Game Menggunakan Fuzzy Sugeno
Authors: Nurhasan Usman 
Published: August 2020

Game merupakan sarana hiburan dan memungkinkan untuk dijadikan sebagai sarana informasi. Game yang baik adalah game yang memiliki otomasi dalam menentukan perilaku NPC didalamnya. NPC harus dapat bergerak secara dinamis sesuai dengan aturan yang berlaku. Dalam penelitian ini, digunakan metode logika Fuzzy Sugeno untuk mengatur perilaku NPC. Terdapat 2 jenis NPC yang ada pada game ini yaitu tipe jarak dekat dan jarak jauh. Dalam mengatur NPC ini memiliki parameter input fuzzy yaitu jarak antara pemain dan npc, damage npc, kecepatan gerak npc, dan nyawa npc. Penerapan fuzzy dalam permainan ini telah berjalan dengan baik dan sesuai dengan rules yang telah ditentukan. Hal ini ditunjukkan dengan melakukan percobaan pada 24 variasi rule fuzzy, hasil yang defuzzyfikasi yang didapatkan adalah 100% dan sesuai dengan perancangan rule. Implementasi engine fuzzy dalam aplikasi game juga berjalan dengan baik. Ujicoba dilakukan pada 30 kondisi dengan berbagai variasi value pada variabel, aplikasi mengeluarkan output yang benar sesuai dengan rule yang telah ditetapkan. Dari variasi pengujian tersebut, 53% NPC akan bergerak mendekati player dan 47% NPC akan diam.
Effects of Radiation on Protein
Authors: Zhang Rong Ke , Lyu Jia Hua , Li Tao 
Published: August 2020

Abstract:
Radiotherapy is one of the most common treatments used for solid tumors. Proteins are important components of all cells and tissues, and the main material basis of life. In the present research, more attention has been paid to the relationship between tumor radiotherapy and glycolipid metabolism, but less attention has been paid to the post-radiation effect of proteins. This article discusses the direct and indirect effects of radiation on proteins. The direct effects include changes in the structure and function of proteins, as well as to their synthesis and degradation, with the most specific effects observed on the post-translational modification of proteins. Indirect effects include changes in the whole-body nutrition level of patients, including the process of protein intake, digestion, absorption and metabolism. This article also addresses the impact of advanced radiotherapy technology, such as proton therapy and heavy ion therapy on proteins, and emphasizes the importance and feasibility of protein-supplying nutritional treatment during the “peri-radiotherapy period”.
Nutritional Status, Sarcopenia and the Importance of Prehabilitation of Gastrointestinal Tumor Patients: a Surgical Point of View
Authors: Lukovich Péter , Nagy Ákos , Barok Bianka , Csiba Borbála , Rokka Ram , Pőcze Balázs 
Published: August 2020

Abstract:

Background
Surgery may be the field of healthcare where malnutrition and sarcopenia have their greatest impact on patient morbidity and mortality. However, there are limited data on the nutritional status of surgical patients and the effects of prehabilitation on the outcomes of surgery.

Methods
A prospective analysis was conducted on all patients surgically-treated for malignant gastrointestinal tumors at St. John Hospital during a two-year period. The patient’s gender, age, body weight, height, BMI and weight loss were registered, then a risk score was determined by the MUST survey. Measurement of the triceps and thigh skin-fold thickness and the circumference of the upper arm and thigh were done to calculate muscle area and muscle index, respectively. The body composition was assessed using an OMRON-BF511 device. Muscle function was evaluated based on hand clamping force measurement and activity tests. Patients who were diagnosed as being at-risk received preoperative prehabilitation, which included physiotherapy and nutritional therapy.

Results
A total of 231 patients (133 males/98 females) were analyzed. They had a mean age of 68.9 years (18∼98). Seventy-four patients (32%) lost weight, with an average loss of 7 kilograms (3∼15 kg). Anthropometric data showed an average upper-arm circumference of 27.4 cm (14.3∼38.1) and thigh circumference of 44.7 cm (19.3∼60.1), so the median muscle index was 1.29. The mean BMI was 26, which is above normal, and the elevated BMI was consistent documented in each patient subgroup stratified by age and tumor type. A body composition analysis was performed for 75 patients (44 male/31 female), who had a median age of 68 (37∼88 y). The average BMI of these patients was 25.7 y and their average MUST score was 1.12. The total body fat percentage (of the total body mass) was 29.5%, total muscle was 30.1% and visceral fat was 10%. Thirty patients (40%) had sarcopenia, with a mean BMI of 28.7, fat comprising 34.2% of the body mass, visceral-fat 11%, and muscle 27.1 %, and their median MUST score was 1.23. Patients who received preoperative training (physiotherapy) showed improvements in physical function ranging from 12%∼33%.

Conclusion
Gastrointestinal tumor patients have a higher than normal BMI regardless of age or tumor type. Patients with sarcopenia show measurable improvement after two weeks of prehabilitation.
Effect of Weight Loss on Survival in Esophageal Cancer Patients undergoing Neoadjuvant Chemoradiotherapy and Surgery
Authors: Lyu Jia Hua , Li Tao , Han Yong Tao , Wu Lei , Peng Lin , Wang Qi Feng , Liang Long 
Published: August 2020

Abstract:

Objective
This study aimed to determine the impact of weight loss during neoadjuvant chemoradiotherapy on the survival of patients with esophageal carcinoma.

Methods
We retrospectively examined 102 consecutive patients with esophageal carcinoma who underwent neoadjuvant chemoradiotherapy followed by radical resection at Sichuan Cancer Hospital & Institute between 2003 and 2017. The patients were divided into three groups based on the amount of body weight lost during neoadjuvant chemoradiotherapy: severe weight loss (>10%), high weight loss (5%∼10%), and low weight loss (< 5%). The correlations of weight loss with toxicity, progressionfree survival, and overall survival were investigated.

Results
The median overall survival was 49.7 months in the low weight loss group compared with 35.4 and 25.1 months in the high and severe weight loss groups (P = 0.041). The 1-year overall survival rates in the severe, high, and low weight loss groups were 62.5%, 85.0%, and 90.7%, respectively; the corresponding 3-year overall survival rates were 21.9%, 47.3%, and 68.8%, respectively, and the corresponding 5-year overall survival rates were 21.9%, 31.0%, and 44.4%, respectively. The multivariate analysis indicated that a pathological complete response and severe weight loss were independent prognostic factors for overall survival. Any leukopenia (P = 0.024), leukopenia of at least grade 3 (P = 0.021), and anemia (P = 0.042) occurred more frequently in the severe weight loss group.

Conclusions
Weight loss during neoadjuvant CRT is an independent and adverse prognostic factor in esophageal carcinoma patients, whereas a stable weight confers a better prognosis.