bluuebunny/crossref_metadata_2025_split huggingface dataset:
LA RESTAURACIÓN DE LA TORRE DEL ZAMBULLÓN (MOTRIL, ESPAÑA): OPORTUNIDAD PARA RECUPERAR UN BIEN DE INTERÉS CULTURAL Y FAVORECER EL DESARROLLO LOCAL / / / \ \ \ THE RESTORATION OF THE ZAMBULLÓN TOWER: OPPORTUNITY TO RECOVER AN ASSET OF CULTURAL INTEREST AND PROMOTE LOCAL DEVELOPMENT
Authors: Sánchez Holgado José Ramón 
Published: July 2020

Resumen. El patrimonio territorial constituye un recurso fundamental de explotación principalmente a escala local y comarcal, que le puede proporcionar con unos objetivos definidos y las estrategias adecuadas diferentes posibilidades de promoción cultural, natural y turística. Con la intención de realzar y poner en valor la torre del Zambullón (término municipal de Motril, Andalucía, España), se realizó una intensa búsqueda documental que nos ha permitido conocer su pasado y junto a unas imprescindibles jornadas de campo, analizar sus posibilidades de integración en la sociedad de la que forma parte. Una vez presentadas unas propuestas generales de intervención y teniendo en cuenta las conclusiones alcanzadas, este estudio de investigación tiene la convicción de que con una restauración adecuada, se conseguiría la recuperación por su temática de un bien de interés cultural único en la costa granadina, contribuyendo de forma simultánea al desarrollo territorial sostenible.

Palabras clave: Geografía de la Memoria, Cartografía, Interpretación del Patrimonio, Paisaje Cultural.

Abstract. Territorial heritage constitutes a fundamental resource whose exploitation, with defined objectives and with the appropriate strategies, can provide different possibilities of cultural, natural and tourist promotion, mainly at local and regional level. With the intention of enhancing and assessing Zambullón tower (Motril, Andalucía, Spain), an intense documentary search and field days have been carried out, which have allowed us to know its past and analyze its possibilities of integration in the society of which it is part. Once some general proposals for intervention have been presented and taking into account the conclusions reached, this research study has the conviction that with an adequate restoration, the recovery of a good of unique cultural interest in the Coast of Granada would be achieved, contributing simultaneously to sustainable territorial development.

Key words: Geography of Memory; Mapping; Heritage Interpretation; Cultural Landscape.
RESEÑA. ¿LUGARES QUE NO IMPORTAN? LA DESPOBLACIÓN DE LA ESPAÑA RURAL DESDE 1900 HASTA EL PRESENTE
Authors: Losilla Casas Celia 
Published: July 2020

Resumen. La obra “¿Lugares que no importan? La despoblación de la España rural desde 1900 hasta el presente” realiza un profundo análisis del fenómeno de la despoblación en el medio rural español mediante el estudio del proceso y de las diferentes cuestiones que han influido en él durante el siglo XX, con el objetivo de explicar las causas que lo provocaron, exponer la situación actual, señalar las consecuencias en el territorio y, finalmente, desmentir mitos en torno a la cuestión.

Palabras clave: espacios rurales, espacios urbanos, demografía, agricultura, estilos de vida, problema territorial.
Characteristics of Patients with Charcot's Arthropathy and its Complications in the Saudi Diabetic Population: A Cross-Sectional Study
Authors: Al-Rubeaan Khalid , Aburisheh Khaled H. , Al Farsi Yousuf , Al Derwish Mohammad , Ouizi Samir , Alblaihi Fahad , ALHagawy Ali Jaber , AlSalem Rakan Khalid , Alageel Musab Abdualaziz , Toledo Mona Heide , Youssef Amira M. 
Published: July 2020

Background
Charcot's arthropathy (CA) is a destructive rare complication of diabetes, and its diagnosis remains challenging for foot specialists and surgeons. We aimed to assess the clinical presentation and characteristics of CA and the frequencies of its various types.

Methods
This cross-sectional study was conducted from January 1, 2007, to December 31, 2016, and included 149 adults with diabetes diagnosed as having CA. Cases of CA were classified based on the Brodsky anatomical classification into five types according to location and involved joints.

Results
The mean ± SD age of the studied cohort was 56.7 ± 11 years, with a mean ± SD diabetes duration of 21.2 ± 7.0 years. The CA cohort had poorly controlled diabetes and a high rate of neuropathy and retinopathy. The most frequent type of CA was type 4, with multiple regions involved at a rate of 56.4%, followed by type 1, with midfoot involvement at 34.5%. A total of 47.7% of the patients had bilateral CA. Complications affected 220 limbs, of which 67.7% had foot ulceration. With respect to foot deformity, hammertoe affected all of the patients; hallux valgus, 59.5%; and flatfoot, 21.8%.

Conclusions
There is a high rate of bilateral CA, mainly type 4, which could be attributed to cultural habits in Saudi Arabia, including footwear. This finding warrants increasing awareness of the importance of maintaining proper footwear to avoid such complications. Implementation of preventive measures for CA is urgently needed.
Bringing Otorhinolaryngological Service to Workplaces: Impact of World Hearing Day
Authors: Akpalaba I. O. , Olarinoye O. T. , Ogisi F. O. 
Published: July 2020

Introduction: Individuals do not seek otorhinolaryngological service due to busy schedules at workplaces. Aim of this study was to identify common and asymptomatic otological conditions and profer solutions; to determine the awareness of otorhinolaryngological services in workplaces.
Methods: A 2-year prospective study done in 2017 and 2018 from 3rd to 31st March of these years, in Edo and Ondo states respectively. Study centers were Independence Television, Nigerian Television Authority; God is Good Motors, De Modern Motors, First Bank, Hope and Echos Hospitals in Benin City; Trauma center and Main auditorium UNIMED in Ondo state. Study was to mark the World Hearing Day. It commenced after obtaining clearance, permissions and informed consents. Total sampling technique was used. Health education was given. Self-administered questionnaires were completed. Otoscopy was done, each ear regarded as a separate entity. Wax and foreign bodies found were removed. Those with ear pathologies were referred to centers with otorhinolaryngological facility for further management. Data analyzed with SPSS, 20. P<0.05 was considered statistically significant.
Results: 192 participants, representing 384 ears were examined. Age ranged from 16 to 68 years. Commonest otological condition was Otitis media with effusion in 36.7% and 33.3% in Edo and Ondo states respectively. Commonest asymptomatic condition was Cerumen auris. Awareness of ORL services was 60% and 85.1% in Edo and Ondo states respectively. Association between demographics and awareness was statistically significant with age, education and occupation.
Conclusion: Otological diseases abound in individuals at workplaces. Though there is high level of awareness, there is presence of asymptomatic otological conditions.
Serum Hepcidin as an Inflammatory Marker in Chronic Kidney Disease
Authors: Roy Jyothi Elizabeth , Shanthi B. , Selvi V. S. Kalai 
Published: July 2020

Background: Hepcidin is known to be the central regulator of iron homeostasis in the body. It is up-regulated by inflammation and downregulated by anemia. CKD is a state of chronic inflammation seen in kidney. Previous work has shown that serum hepcidin levels were increased in patients with CKD. This was surprising as these patients had a chronic inflammatory state and co-existent anemia.
Aim and Objectives: The aim of the study is to estimate the levels of hepcidin in CKD patients and to check the correlation of hepcidin to inflammation in chronic kidney disease.
Methods: This cross-sectional study was conducted at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of chronic kidney disease in the age group of 18-60 years. The blood samples were collected using vacutainer system. Samples for serum hepcidin, ferritin and hsCRP were collected in red topped plain vacuum tube. The samples were centrifuged at 3000 rpm for 15 minutes. The samples were then processed, and values were obtained. The data were analysed using SPSS package.
Results: The mean values of s. Hepcidin, s. ferritin and hsCRP levels were found to be increased in the study population. The mean value of s. hepcidin was found to have strong positive correlation with the mean values of s. ferritin and hsCRP with r-value > 0.7.
Conclusion: Hepcidin levels are elevated in CKD and hepcidin is a predictor of inflammation since it correlated well with the inflammatory markers hsCRP and ferritin levels.
Hippocampal sclerosis, TDP‐43, and the duration of the symptoms of dementia of AD patients
Authors: Lopez Oscar L. , Kofler Julia , Chang YueFang , Berman Sarah B. , Becker James T. , Sweet Robert A. , Nadkarni Neelesh , Patira Riddhi , Kamboh M. Ilyas , Cohen Ann D. , Snitz Beth E. , Kuller Lewis H. , Klunk William E. 
Published: July 2020

AbstractObjectivesTo examine the relationship between duration of the cognitive symptoms, from the earliest reported symptom to death, and hippocampal sclerosis (HS) and TAR‐DNA binding protein of 43kDA (TDP‐43) in Alzheimer’s disease (AD) patients.MethodsThe study was conducted in 359 cognitively impaired patients who met the pathological criteria for AD (NIA‐Reagan intermediate or high). The mean age at onset was 69.5 ± 8.8 years (range 37‐95) and the mean duration of the symptoms was 10.5 ± 4.2 years. The association between symptoms duration and HS and TDP‐43 was examined with logistic regression analyses controlling for age at death, atherosclerosis in the Circle of Willis (CW), cerebral infarcts, gender, baseline Mini Mental State Examination scores, APOE‐4 allele, and presence of Lewy bodies (LB).ResultsHS was present in 18% (n = 64) and TDP‐43 in 51.5% (n = 185) of the patients. HS and TDP‐43 were more frequent in patients whose symptoms lasted more than 10 years. LBs were present in 72% of the patients with HS and in 64% of the patients with TDP‐43. Age at onset was not associated with TDP‐43 or HS. HS was associated with duration of symptoms and LB, TDP‐43, and atherosclerosis in the CW. TDP‐43 was associated with duration of symptoms, LB, and HS.InterpretationHS and TDP‐43 are present in early and late onset AD. However, their presence is mainly driven by the duration of symptoms and the presence of LB. This suggests that HS and TDP‐43 are part of the later neuropathological changes in AD.
The modified extended Kalman filter based recursive estimation for Wiener nonlinear systems with process noise and measurement noise
Authors: Wang Xuehai , Zhu Fang , Ding Feng 
Published: July 2020

SummaryThis article develops the modified extended Kalman filter based recursive estimation algorithms for Wiener nonlinear systems with process noise and measurement noise. The prior estimate of the linear block output is computed based on the auxiliary model, and the posterior estimate is updated by designing a modified extended Kalman filter. A multi‐innovation gradient algorithm and a recursive least squares algorithm are derived to estimate the parameters of the linear subsystem, respectively. The simulation examples are provided to demonstrate the effectiveness of the proposed algorithms.
A Biomimetic, Stem Cell‐Derived In Vitro Ocular Outflow Model
Authors: Tian Yangzi Isabel , Zhang Xulang , Torrejon Karen , Danias John , Du Yiqin , Xie Yubing 
Published: July 2020

AbstractAge‐related human trabecular meshwork (HTM) cell loss is suggested to affect its ability to regulate aqueous humor outflow in the eye. In addition, disease‐related HTM cell loss is suggested to lead to elevated intraocular pressure in glaucoma. Induced pluripotent stem cell (iPSC)‐derived trabecular meshwork (TM) cells are promising autologous cell sources that can be used to restore the declining TM cell population and function. Previously, an in vitro HTM model is bioengineered for understanding HTM cell biology and screening of pharmacological or biological agents that affect trabecular outflow facility. In this study, it is demonstrated that human iPSC‐derived TM cells cultured on SU‐8 scaffolds exhibit HTM‐like cell morphology, extracellular matrix deposition, and drug responsiveness to dexamethasone treatment. These findings suggest that iPSC‐derived TM cells behave like primary HTM cells and can thus serve as reproducible and scalable cell sources when using this in vitro system for glaucoma drug screening and further understanding of outflow pathway physiology, leading to personalized medicine.
Black‐Phosphorus‐Incorporated Hydrogel as a Conductive and Biodegradable Platform for Enhancement of the Neural Differentiation of Mesenchymal Stem Cells
Authors: Xu Chao , Xu Yin , Yang Ming , Chang Yukai , Nie Anmin , Liu Zhongyuan , Wang Jianglin , Luo Zhiqiang 
Published: July 2020

AbstractConductive hydrogel scaffolds have important applications for electroactive tissue repairs. However, the development of conductive hydrogel scaffolds tends to incorporate nonbiodegradable conductive nanomaterials that will remain in the human body as foreign matters. Herein, a biodegradable conductive hybrid hydrogel is demonstrated based on the integration of black phosphorus (BP) nanosheets into the hydrogel matrix. To address the challenge of applying BP nanosheets in tissue engineering due to its intrinsic instability, a polydopamine (PDA) modification method is developed to improve the stability. Moreover, PDA modification also enhances interfacial bonding between pristine BP nanosheets and the hydrogel matrix. The incorporation of polydopamine‐modified black phosphorous (BP@PDA) nanosheets into the gelatin methacryloyl (GelMA) hydrogels significantly enhances the electrical conductivity of the hydrogels and improves the cell migration of mesenchymal stem cells (MSCs) within the 3D scaffolds. On the basis of the gene expression and protein level assessments, the BP@PDA‐incorporated GelMA scaffold can significantly promote the differentiation of MSCs into neural‐like cells under the synergistic electrical stimulation. This strategy of integrating biodegradable conductive BP nanomaterials within a biocompatible hydrogel provides a new insight into the design of biomaterials for broad applications in tissue engineering of electroactive tissues, such as neural, cardiac, and skeletal muscle tissues.
An Energy‐Dense Solvent‐Free Dual‐Ion Battery
Authors: Chen Chih‐Yao , Matsumoto Kazuhiko , Kubota Keigo , Hagiwara Rika , Xu Qiang 
Published: July 2020

AbstractEver‐increasing energy demands call for alternative energy storage technologies with balanced performance and cost characteristics to meet current and emerging applications. Dual‐ion batteries (DIBs) are considered particularly attractive owing to the potentially high specific energy, a rich variety of charge carrier combinations, and the applicability of metal‐free cathode and earth‐abundant anode materials. However, their performance falls far below expectations because of a large excess of solvent needed to dissolve electroactive species that induces side reactions and contributes parasitic weight, which penalizes the reversible capacity and cell‐level energy density. Herein, a solvent‐free DIB utilizing a binary alkali metal molten salt based on bis(fluorosulfonyl)amide as the electrolyte to solve these issues is demonstrated. The cell (NaK‐DIB) operates in a temperature range of 90–120 °C and exhibits high theoretical energy densities of 246 Wh kg−1 and 533 Wh L−1 based on active materials and capacity‐matched electrolyte, far surpassing those of reported DIBs. Further improvements could realize affordable grid‐scale energy storage.
Biomaterial Based Strategies for Engineering New Lymphatic Vasculature
Authors: Campbell Kevin T. , Silva Eduardo A. 
Published: July 2020

AbstractThe lymphatic system is essential for tissue regeneration and repair due to its pivotal role in resolving inflammation, immune cell surveillance, lipid transport, and maintaining tissue homeostasis. Loss of functional lymphatic vasculature is directly implicated in a variety of diseases, including lymphedema, obesity, and the progression of cardiovascular diseases. Strategies that stimulate the formation of new lymphatic vessels (lymphangiogenesis) could provide an appealing new approach to reverse the progression of these diseases. However, lymphangiogenesis is relatively understudied and stimulating therapeutic lymphangiogenesis faces challenges in precise control of lymphatic vessel formation. Biomaterial delivery systems could be used to unleash the therapeutic potential of lymphangiogenesis for a variety of tissue regenerative applications due to their ability to achieve precise spatial and temporal control of multiple therapeutics, direct tissue regeneration, and improve the survival of delivered cells. In this review, the authors begin by introducing therapeutic lymphangiogenesis as a target for tissue regeneration, then an overview of lymphatic vasculature will be presented followed by a description of the mechanisms responsible for promoting new lymphatic vessels. Importantly, this work will review and discuss current biomaterial applications for stimulating lymphangiogenesis. Finally, challenges and future directions for utilizing biomaterials for lymphangiogenic based treatments are considered.
Four Aspects about Solid‐State Nanopores for Protein Sensing: Fabrication, Sensitivity, Selectivity, and Durability
Authors: Hu Rui , Tong Xin , Zhao Qing 
Published: July 2020

AbstractSolid‐state nanopores are a mimic of innate biological nanopores embedded on lipid membranes. They are fabricated on thin suspended layers of synthetic materials that provide superior thermal, mechanical, chemical stability, and geometry flexibility. As their counterpart biological nanopores reach the goal of DNA sequencing and become commercial, solid‐state nanopores thrive in aspects of protein sensing and have become an important research component for clinical diagnostic technologies. This review focuses on resistive pulse sensing modes, which are versatile for low‐cost, portable sensing devices and summarizes four main aspects toward commercially available resistive pulse‐based protein sensing techniques using solid‐state nanopores. In each aspect of fabrication, sensitivity, selectivity, and durability, brief fundamentals are introduced and the challenges and improvements are discussed. The rapid advance of a practical technique requires greater multidisciplinary cooperation. The review aims at clarifying existing obstacles in solid‐state nanopore based protein sensing, intriguing readers with existing solutions and finally encouraging multidisciplinary researchers to advance the development of this promising protein sensing methodology.
Charge‐Balancing Redox Mediators for High Color Contrast Electrochromism on Polyoxometalates
Authors: Wang Shi‐Ming , Wang Yuhao , Wang Tao , Han Zhengbo , Cho Cheolhyun , Kim Eunkyoung 
Published: July 2020

AbstractA nonaqueous charge‐balancing electrolyte with a redox couple (I−/I3−) is investigated to improve the electrochromic (EC) performance of polyoxometalate (POM)‐based electrochromic devices (ECDs). PW12O403− (PW12)‐coated porous TiO2 nanoparticle films (PWTNF) with different thicknesses are used as the working electrode. The optical contrast (ΔT) of the optimized PW12‐ECDs reached 59.4% with the electrolyte containing the I−/I3− redox couple. PW12‐ECDs also show a fast response time for bleaching (tb,90% = 1.9 s) and coloration (tc,90% = 3.1 s). On the contrary, without the I−/I3− redox couple, PW12‐ECDs show a poor ΔT of 4.0% and slow response times (>9.0 s). The role of the I−/I3− couple is identified as a charge‐balancing redox mediator between PW12 and the counter electrode. Li+ is the effective intercalating/deintercalating cation required for the EC reaction of PW12. Thus, by simply introducing the I−/I3− redox couple into the electrolyte significantly boosts the EC performance of POMs.
Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications
Authors: Zeidell Andrew M. , Ren Tong , Filston David S. , Iqbal Hamna F. , Holland Emma , Bourland J. Daniel , Anthony John E. , Jurchescu Oana D. 
Published: July 2020

AbstractRadiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors faced by current technologies in approximating the dose profile in a patient's body, is sensitive for doses relevant to radiation treatment procedures, and robust when incorporated into conformal large‐area electronics. A model is proposed to describe the operation of RAD‐OFETs, based on the interplay between charge photogeneration and trapping.
All‐Polymer Solar Cells with over 12% Efficiency and a Small Voltage Loss Enabled by a Polymer Acceptor Based on an Extended Fused Ring Core
Authors: Yao Huatong , Ma Lik‐Kuen , Yu Han , Yu Jianwei , Chow Philip C. Y. , Xue Wenyue , Zou Xinhui , Chen Yuzhong , Liang Jiaen , Arunagiri Lingeswaran , Gao Feng , Sun Huiliang , Zhang Guangye , Ma Wei , Yan He 
Published: July 2020

AbstractAlthough the field of all‐polymer solar cells (all‐PSCs) has seen rapid progress in device efficiencies during the past few years, there are limited choices of polymer acceptors that exhibit strong absorption in the near‐IR region and achieve high open‐circuit voltage (VOC) at the same time. In this paper, an all‐PSC device is demonstrated with a 12.06% efficiency based on a new polymer acceptor (named PT‐IDTTIC) that exhibits strong absorption (maximum absorption coefficient: 2.41 × 105 cm−1) and a narrow optical bandgap (1.49 eV). Compared to previously reported polymer acceptors such as those based on the indacenodithiophene (IDT) core, the indacenodithienothiophene (IDTT) core has further extended fused ring, providing the polymer with extended absorption into the near‐IR region and also increases the electron mobility of the polymer. By blending PT‐IDTTIC with the donor polymer, PM6, a high‐efficiency all‐PSC is achieved with a small voltage loss of 0.52 V, without sacrificing JSC and FF, which demonstrates the great potential of high‐performance all‐PSCs.