bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the spatial and temporal shift in the archetypal seasonal temperature cycle as driven by annual and semi‐annual harmonics
Authors: North Joshua S. , Schliep Erin M. , Wikle Christopher K. 
Published: December 2020

AbstractStatistical methods are required to evaluate and quantify the uncertainty in environmental processes, such as land and sea surface temperature, in a changing climate. Typically, annual harmonics are used to characterize the variation in the seasonal temperature cycle. However, an often overlooked feature of the climate seasonal cycle is the semi‐annual harmonic, which can account for a significant portion of the variance of the seasonal cycle and varies in amplitude and phase across space. Together, the spatial variation in the annual and semi‐annual harmonics can play an important role in driving processes that are tied to seasonality (e.g., ecological and agricultural processes). We propose a multivariate spatiotemporal model to quantify the spatial and temporal change in minimum and maximum temperature seasonal cycles as a function of the annual and semi‐annual harmonics. Our approach captures spatial dependence, temporal dynamics, and multivariate dependence of these harmonics through spatially and temporally varying coefficients. We apply the model to minimum and maximum temperature over North American for the years 1979–2018. Formal model inference within the Bayesian paradigm enables the identification of regions experiencing significant changes in minimum and maximum temperature seasonal cycles due to the relative effects of changes in the two harmonics.
Analysis of different operating strategies of thermal energy storage with radiant cooling system
Authors: Singh Rana Veer Pratap , Mathur Jyotirmay , Bhandari Mahabir 
Published: December 2020

SummaryThermal energy storage systems in building cooling applications have been explored extensively as a peak load‐shifting technology. Thermal energy storage performance has been recognized and studied from an energy cost‐savings point of view because of peak‐valley price differences, but not many studies have been conducted from an energy savings viewpoint. This study experimentally investigates the performance of the energy storage‐retrofitted to a ceiling‐type radiant cooling system. To study the performance, a water‐based storage system was designed and developed for an academic office building equipped with a radiant cooling system. The water in the storage tank was cooled to a certain storage temperature in the nighttime, and the same water was used during the daytime for meeting the cooling load. Different combinations of charging and discharging schedules were analyzed. The key objective of the study was to achieve energy savings and energy‐cost savings simultaneously. This objective was accomplished by identifying the major factors contributing to the energy consumption of the storage‐retrofitted cooling system and devising novel operating strategies, leading to an enhanced energy savings potential. Two operating strategies comprising 24 operating scenarios were compared and the storage was used to dispatch the load for 3 hours of the day as a full storage unit. Results showed that in hot and dry climate conditions, using the storage with the radiant cooling system offered energy savings of 3% to 14%. The energy‐cost analysis was also performed using a time‐of‐day electricity tariff plan. The energy‐cost savings varied from 17.5% to 22.4% for these operating scenarios.
Novel voice prosthesis after total laryngectomy with laryngoplasty reconstruction
Authors: Feng Allen L. , Zenga Joseph , Varvares Mark A. 
Published: December 2020

AbstractBackgroundAlthough many patients achieve serviceable speech after total laryngectomy (TL), others are limited by un‐naturally low pitch. We describe a cadaveric study to provide proof of concept for a novel voice prosthesis after TL with free tissue laryngoplasty.MethodsDevices were implanted into fresh frozen cadavers after TL and free tissue laryngoplasty. Phonation pressures were measured using a custom Blom‐Singer Manometer (InHealth Technologies, Carpinteria, CA) and acoustic files were analyzed using Praat, a speech analysis software.ResultsTwo fresh frozen cadavers were implanted with the voice prosthesis. Both prostheses demonstrated appropriate stenting of the laryngoplasty. Successful sound production was achieved after airflow generation at the proximal trachea. An average phonation pressure of 3.5 cmH2O (SD 1.7 cmH2O) was necessary to generate a sound intensity of 80.6 dB (SD 0.2 dB) at an average fundamental frequency of 299.5 Hz (SD 112.6 Hz).ConclusionsThe novel voice prosthesis described herein offers a feasible voice generation mechanism.
A note on reserve requirements and banks' liquidity
Authors: Bitar Joseph 
Published: December 2020

AbstractUnlike past literature adopting the loanable funds view, we follow the financing model of bank intermediation in order to analyse the monetary mechanisms relating to reserve requirements and compute banks' margins on their lending and deposit activities. We show that, when remunerated at a rate below the money market interest rate, reserve requirements increase the spread between bank loans and deposits interest rates, without any impact on the level of interest rates. We review and analyse the uses of reserve requirements as a prudential tool and as a monetary policy instrument. We also analyse their use for capital flows management and for de‐dollarization in emerging economies. We argue that reserve requirements are a sub‐optimal and outdated policy tool, and we suggest imposing direct taxes on banks' deposits and loans interest payments, as a more efficient alternative to reserve requirements.
Features of α‐HBDH in COVID‐19 patients: A cohort study
Authors: Zhu Haoming , Qu Gaojing , Yu Hui , Huang Guoxin , Chen Lei , Zhang Meiling , Wan Shanshan , Pei Bin 
Published: December 2020

AbstractBackgroundCoronavirus disease‐2019 (COVID‐19) has spread all over the world and brought extremely huge losses. At present, there is a lack of study to systematically analyze the features of hydroxybutyrate dehydrogenase (α‐HBDH) in COVID‐19 patients.MethodsElectronic medical records including demographics, clinical manifestation, α‐HBDH results and outcomes of all included patients were extracted.Resultsα‐HBDH in COVID‐19 group was higher than that in excluded group (p < 0.001), and there was no significant difference in α‐HBDH before and after the exclusion of 5 patients with comorbidity in heart or kidney (p = 0.671). In COVID‐19 group, the α‐HBDH value in ≥61 years old group, severe group, and critical group, death group all increased at first and then decreased, while no obvious changes were observed in other groups. And there were significant differences of the α‐HBDH value among different age groups (p < 0.001), clinical type groups (p < 0.001), and outcome groups (p < 0.001). The optimal scale regression model showed that α‐HBDH value (p < 0.001) and age (p < 0.001) were related to clinical type.Conclusionsα‐HBDH was increased in COVID‐19 patients, obviously in ≥61 years old, death and critical group, indicating that patients in these three groups suffer from more serious heart and kidney and other tissues and organs damage, higher α‐HBDH value, and risk of death. The difference between death and survival group in early stage might provide a approach to judge the prognosis. The accuracy of the model to distinguish severe/critical type and other types was 85.84%, suggesting that α‐HBDH could judge the clinical type accurately.
Erythroferrone structure, function, and physiology: Iron homeostasis and beyond
Authors: Srole Daniel N , Ganz Tomas 
Published: December 2020

AbstractErythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone controlling plasma iron levels and total body iron. When the release of erythropoietin from the kidney stimulates the production of new red blood cells, it also increases the synthesis of ERFE in bone marrow erythroblasts. Increased ERFE then suppresses hepcidin synthesis, thereby mobilizing cellular iron stores for use in heme and hemoglobin synthesis. Recent mechanistic studies have shown that ERFE suppresses hepcidin transcription by inhibiting bone morphogenetic protein signaling in hepatocytes. In ineffective erythropoiesis, pathological overproduction of ERFE by an expanded population of erythroblasts suppresses hepcidin and causes iron overload, even in non‐transfused patients. ERFE may be a useful biomarker of ineffective erythropoiesis and an attractive target for treating its systemic effects.
Effect of storage, temperature, and extraction kit on the phylogenetic composition detected in the human milk microbiota
Authors: Lyons Katriona E. , Fouhy Fiona , O’ Shea Carol‐Anne , Ryan C. Anthony , Dempsey Eugene M. , Ross R. Paul , Stanton Catherine 
Published: December 2020

AbstractHuman milk is considered the optimum feeding regime for newborns and is a source of bacteria for the developing infant gastrointestinal tract. However, as with all low biomass samples, standardization across variabilities such as sample collection, storage, and extraction methods is needed to eliminate discrepancies in microbial composition across studies. The aim of this study was to investigate how different storage methods, temperatures, preservatives, and extraction kits influence the human milk microbiome, compared to fresh samples. Breast milk samples were processed via six different methods: fresh (Method 1), frozen at −80°C (Method 2), treated with RNAlater and stored at 4°C or −80°C (Methods 3 and 4), and treated with Milk Preservation Solution at room temperature (Methods 5 and 6). Methods 1‐5 were extracted using PowerFoodTM Microbial DNA Isolation kit (Mobio), and Method 6 was extracted using Milk DNA Preservation and Isolation kit (Norgen BioTek). At genus level, the most abundant genera were shared across Methods 1‐5. Samples frozen at −80°C had fewest significant changes while samples treated and extracted using Milk Preservation and Isolation kit had the most significant changes when compared to fresh samples. Diversity analysis indicated that variation in microbiota composition was related to the method and extraction kit used. This study highlighted that, when extraction from fresh milk samples is not an option, freezing at −80°C is the next best option to preserve the integrity of the milk microbiome. Furthermore, our results demonstrate that choice of extraction kit had a profound impact on the microbiota populations detected in milk.
A distance based multiple criteria sorting method without class thresholds
Authors: Karasakal Esra , Civelek Merve 
Published: December 2020

AbstractIn this paper, a new distance‐based sorting method (DISWOTH) that does not require specifying class thresholds between preference‐ordered classes is developed for multiple criteria sorting problems. The aim of the DISWOTH method is to assign each alternative to a class or a set of possible adjacent classes considering distance to class centroids. Distance of alternatives to centroids are used as a criteria aggregation function. A mathematical model is formulated to determine weights of criteria. Assignment is performed according to the weighted distance of each alternative to class centroids. Performance of the DISWOTH method is compared with the Preference DISaggregation analysis (PDIS) and the UTilites Additives DIScriminantes (UTADIS) methods from literature.
Skeletal remains of five blue foxes (Vulpes lagopus) from St. Paul Island, Pribilof Islands, Alaska: A view of differential diagnosis
Authors: Lawler Dennis F. , Tangredi Basil P. , Etnier Michael A. 
Published: December 2020

AbstractWe evaluated skeletal remains of five blue arctic foxes from St. Paul Island, Pribilof Islands, Alaska. All five had been found dead. Cleared skeletal remains were examined visually and by magnification or backlighting where necessary. Pathological features were described and photographed. Results suggested that more than one disorder may have occurred in these foxes, with primary observations being demineralizing and/or proliferation. Most prominently affected were the skull, maxillae, mandibles, pelvis, long bones, and major diarthrodial joints. It was critically important to recognize certain other pathological features that can be observed on many or most fox skeletal remains but are unlikely to relate to conditions that demineralize bone or cause overt bone loss, multifocal loss of joint architecture, or severe multifocal periarticular boney proliferation. The differential diagnosis of canid skeletal demineralizing includes primary and secondary (nutritional or renal) hyperparathyroidism. Boney proliferation has a wider differential spectrum that can include hypervitaminosis A, osteomyelitis, abnormalities related to inbreeding, and environmental toxicosis. In our view, given the lack of soft tissue for histological evaluation and biochemical analysis, a well‐considered differential diagnosis is an appropriate scientific point of conclusion. In the many similar circumstances that would require additional studies for valid definitive diagnosis during life, investigators should review relevant literature and consider the value of well‐structured differential diagnosis, as contrasted with more speculative definitive diagnoses.
A library of thermoresponsive PEG‐based methacrylate homopolymers: How do the molar mass and number of ethylene glycol groups affect the cloud point?
Authors: Li Qian , Constantinou Anna P. , Georgiou Theoni K. 
Published: December 2020

AbstractIn this study, a novel library of thermoresponsive homopolymers based on poly (ethylene glycol) (EG) (m)ethyl ether methacrylate monomers is presented. Twenty‐seven EG based homopolymers were synthesized and three parameters, the molar mass (MM), the number of the ethylene glycol groups in the monomer, and the chemistry of the functional side group were varied to investigate how these affect their thermoresponsive behavior. The targeted MMs of these polymers are varied from 2560, 5000, 8200 to 12,000 g mol−1. Seven PEG‐based monomers were investigated: ethylene glycol methyl ether methacrylate (MEGMA), ethylene glycol ethyl ether methacrylate (EEGMA), di(ethylene glycol) methyl ether methacrylate (DEGMA), tri(ethylene glycol) methyl ether methacrylate (TEGMA), tri(ethylene glycol) ethyl ether methacrylate (TEGEMA), penta(ethylene glycol) methyl ether methacrylate (PEGMA), nona(ethylene glycol) methyl ether methacrylate (NEGMA). Homopolymers of 2‐(dimethylamino) ethyl methacrylate (DMAEMA) were also synthesized for comparison. The cloud points of these homopolymers were tested in different solvents and it was observed that it decreases as the number of EG group was decreased or the MM increased. Interestingly, the end functional group (methoxy or ethoxy) of the side group has an effect as well and is even more dominant than the number of EG groups.
Fluorescence‐guided D3 lymphadenectomy in robotic right colectomy with complete mesocolic excision
Authors: Petz Wanda , Bertani Emilio , Borin Simona , Fiori Giancarla , Ribero Dario , Spinoglio Giuseppe 
Published: December 2020

AbstractBackgroundIn robotic right hemicolectomy for cancer, appropriate lymphadenectomy is essential. Visualization of draining lymph nodes and blood flow with near‐infrared (NIR) fluorescence DaVinci® imaging system is a recent development. We present the technique of robotic right colectomy with complete mesocolic excision (CME) and D3 lymphadenectomy using Indocyanine Green (ICG) endoscopic submucosal injection to intraoperatively identify tumour lymphatic basin.MethodsThe day before surgery, in patients scheduled for robotic right colectomy an endoscopic submucosal injection of 3 mg of ICG solution around the tumor is realized. Robotic right hemicolectomy is performed with suprapubic trocars layout and “bottom to up dissection”, realizing a CME with central vessel ligation and D3 lymphadenectomy. Site of primary tumor and lymphatic basin are visible with the FireflyTM camera modality.ResultsFrom July 2016 to July 2020, 85 patients received a robotic right colectomy with CME and D3 lymphadenectomy. In 50 patients, ICG submucosal injection was performed: visualisation of the site of primary tumour and of LN in the D3 area was possible in all cases; in 17/50 patients (34%), LN out from anatomical lymphatic basin were identified. No side effects were observed.ConclusionsIn this series, submucosal ICG injection showed to be feasible and safe. The accuracy in identification of D3 lymphatic basin was high, thus permitting an image‐guided radical lymphadenectomy. Fluorescent technology represents an interesting innovation to ameliorate surgery of colon cancer.
Controller and anti‐windup co‐design for the output regulation of rational systems subject to control saturation
Authors: Castro Rafael S. , Flores Jeferson V. , Salton Aurélio T. , Gomes da Silva Jr João M 
Published: December 2020

AbstractThis article presents a novel framework for the output regulation of rational nonlinear systems subject to input saturation, where the controller structure is composed by an internal model generator in series with an output feedback stabilizing stage. In order to address the effects of control saturation, we propose the use of an anti‐windup compensation loop into both internal model and stabilizing control stages. Given prior knowledge of the system zero‐error steady‐state condition and a proper internal model, we cast the regulation error dynamics in a differential‐algebraic form, which leads to matrix inequalities conditions that ensure closed‐loop stability and exponential transient performance. Optimization problems are then proposed to simultaneously compute the stabilizing controller and the anti‐windup gains such that a domain of attraction estimate is maximized.
Understanding the merits of winning data competition solutions for varied sets of objectives
Authors: Lu Lu , Anderson‐Cook Christine M. , Zhang Miaolu 
Published: December 2020

AbstractData competitions provide an efficient cost‐effective way to obtain diverse solutions for challenging problems across a wide variety of applications. The competition leaderboard, by necessity, must combine multiple objectives into a single scoring formula to determine winners and allocate prize money. However, after the competition concludes, the host may wish to choose a best solution for a particular scenario that focuses on only a subset of all the competition objectives. Through the use of Pareto fronts and graphical summaries, we describe how top solutions for a specific scenario can be identified and compared. The strategy uses intentional tie‐handling, thresholds to eliminate undesirable solutions and Pareto fronts to identify objectively superior solutions for a subset of objectives. Then the strengths and weaknesses of different alternatives can be compared to find the ideal solution for the problem. The methods are illustrated with a real Topcoder data competition hosted by Los Alamos National Laboratory that used 16 different objectives to evaluate the quality of solutions for urban radiation search.
Validation of SATURN, a free, electronic, self‐administered cognitive screening test
Authors: Bissig David , Kaye Jeffrey , Erten‐Lyons Deniz 
Published: December 2020

AbstractBackgroundCognitive screening is limited by clinician time and variability in administration and scoring. We therefore developed Self‐Administered Tasks Uncovering Risk of Neurodegeneration (SATURN), a free, public‐domain, self‐administered, and automatically scored cognitive screening test, and validated it on inexpensive (<$100) computer tablets.MethodsSATURN is a 30‐point test including orientation, word recall, and math items adapted from the Saint Louis University Mental Status test, modified versions of the Stroop and Trails tasks, and other assessments of visuospatial function and memory. English‐speaking neurology clinic patients and their partners 50 to 89 years of age were given SATURN, the Montreal Cognitive Assessment (MoCA), and a brief survey about test preferences. For patients recruited from dementia clinics (n = 23), clinical status was quantified with the Clinical Dementia Rating (CDR) scale. Care partners (n = 37) were assigned CDR = 0.ResultsSATURN and MoCA scores were highly correlated (P < .00001; r = 0.90). CDR sum‐of‐boxes scores were well‐correlated with both tests (P < .00001) (r = −0.83 and −0.86, respectively). Statistically, neither test was superior. Most participants (83%) reported that SATURN was easy to use, and most either preferred SATURN over the MoCA (47%) or had no preference (32%).DiscussionPerformance on SATURN—a fully self‐administered and freely available (https://doi.org/10.5061/dryad.02v6wwpzr) cognitive screening test—is well‐correlated with MoCA and CDR scores.
Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
Authors: Scheja Ludger , Heeren Joerg 
Published: December 2020

AbstractAdipose tissue as a major organ of lipid and lipoprotein metabolism has a major impact on metabolic homeostasis and thus influences the development of atherosclerosis and related cardiometabolic diseases. Unhealthy adipose tissue, which is often associated with obesity and systemic insulin resistance, promotes the development of diabetic dyslipidemia and can negatively affect vascular tissue homeostasis by secreting pro-inflammatory peptides and lipids. Conversely, paracrine and endocrine factors that are released from healthy adipose tissue can preserve metabolic balance and a functional vasculature. In this chapter, we describe adipose tissue types relevant for atherosclerosis and address the question how lipid metabolism as well as regulatory molecules produced in these fat depots can be targeted to counteract atherogenic processes in the vessel wall and improve plasma lipids. We discuss the role of adipose tissues in the action of approved drugs with anti-atherogenic activity. In addition, we present potential novel targets and therapeutic approaches aimed at increasing lipoprotein disposal in adipose tissue, boosting the activity of heat-producing (thermogenic) adipocytes, reducing adipose tissue inflammation, and improving or replacing beneficial hormones released from adipose tissues. Furthermore, we describe the future potential of innovative drug delivery technologies.
Introduction to Occupational Safety
Authors: Otto Thomas 
Published: December 2020

AbstractIt is not possible to write a book on Safety at Accelerators, or on occupational safety in general, without a practical understanding of the technical language of the field. Like in other scientific or technical fields, words are used with a specific meaning, often deviating from their everyday use. These terms must be clarified before penetrating deeper into the subject. Central to occupational safety are the terms of hazard, risk, and control. A more detailed description of these concepts is found in Chap. 10.1007/978-3-030-57031-6_5.
Industrial Safety at Particle Accelerators
Authors: Otto Thomas 
Published: December 2020

AbstractThe construction and operation of particle accelerators implies the use of numerous technologies and trades which are well-known from the manufacturing and construction industries. Consequently, their safety hazards are described in the literature and standard best practice solutions exist for controlling the risks emerging from these activities. In this section, the occupational hazards of electricity, mechanical equipment and pressure vessels are illustrated with examples from particle accelerator facilities. Further sections are dedicated to accelerator-specific protection against fire, occupational noise, and environmental damage.