bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISOLATION OF UROPATHOGENS AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERN AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Authors: HARIT KUMAR  , VARSHA A SINGH  , SHAVI NAGPAL  , DIPANKAR BISWAS  
Published: December 2019

Objective: The objective of the study was to know the isolation rate and antibiotic susceptibility pattern of pathogens causing urinary tract infection (UTI).
Methods: A total of 500 urine samples of clinically suspected UTI were collected from January 2019 to June 2019. The samples were inoculated on Cystine Lactose Electrolyte-Deficient agar and incubated at 37°C for 24 h.
Results: In our study, 303 (60.6%) samples showed growth of isolates. Among 303 isolates, 31 were Candida spp. which was not included in the study. Out of 272 isolates, Escherichia coli was 31.68%, followed by Klebsiella spp. (27.72%), Enterococcus faecalis (22.44%), Citrobacter spp. (3.96%), Staphylococcus aureus (2.64%), and Pseudomonas spp. (1.32%). For Gram-negative and Gram-positive isolates, the most effective antibiotic was nitrofurantoin.
Conclusion: The study shows E. coli as the predominant pathogen that causes UTI. Nitrofurantoin and fosfomycin showed very high susceptibility to uropathogens and can be used to treat primary or uncomplicated UTI.
Effects EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) SEED POWDER ON BLOOD GLUCOSE LEVEL IN STREPTOZOTOCIN-INDUCED MICE
Authors: NOVARIANTI MARBUN  , RUTH MAYANA RUMANTI  
Published: December 2019

Objective: The aim of this research is to evaluate the antidiabetic effect of pumpkin seed powder in streptozotocin (STZ)-induced diabetic mice.
Methods: Pumpkin seed was used in seed powder suspension form and then evaluate the phytochemical screening and induced diabetic mice using STZ.
Results: The phytochemical screening showed that pumpkin seed powder has various of phytochemical compounds. The pumpkin seed powder (dose level 100, 150, and 200 mg/kg bw) showed a significant reduction of blood glucose.
Conclusions: Pumpkin seed powder significantly decreases blood glucose level in STZ-induced mice.
ASSESSMENT OF THE CURRENT GERIATRIC PHARMACEUTICAL CARE IN THE UNITED ARAB EMIRATES
Authors: OSAMA MOHAMED IBRAHIM  , RANA IBRAHIM  
Published: December 2019

Objectives: The primary goal of this study is to assess the current geriatric pharmaceutical care and patient satisfaction among elderly patient. Another aim is to increase the awareness among pharmacists in providing better guidelines for proper geriatric pharmaceutical care in the United Arab Emirates (UAE).
Methods: A pilot observational study was done through the dissemination of cross-sectional surveys among pharmacists and geriatrics in the Emirates of Abu Dhabi, Dubai, and Sharjah. Three hundred and eight pharmacists and 110 geriatric patients were randomly selected to participate in the study.
Results: Among pharmacists participating in the study, 32.1% were from Abu Dhabi, 37.6% from Dubai, and 30.1% from Sharjah. Geriatric patients who participated from Abu Dhabi were 30.0%, 38.1% were from Dubai, and 31.8% were from Sharjah. Geriatrics level of satisfaction was higher in Abu Dhabi compared to Sharjah and Dubai (p=0.0005). Pharmacists in Sharjah and Dubai had higher interest in taking special courses on how to deal with elderly patients compared to pharmacists in Abu Dhabi (p<0.0001).
Conclusions: Geriatrics satisfaction toward pharmaceutical care is not the same in all Emirates of the UAE. This calls for implementing diverse measures such as providing training courses for pharmacists specialized in geriatrics care, which aims to provide a high-quality pharmaceutical care to all geriatrics in the UAE.
EVALUATION OF ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICALS ANALYSIS OF WHOLE PLANT EXTRACT OF VINCA ROSEA
Authors: ANGELIN JEBAMALAR JAYARAJ  , JOTHI UCHIMAHALI  , THIYAGARAJAN GNANASUNDARAM  , SIVAKUMAR THIRUMAL  
Published: December 2019

Objectives: The aim of this research work was to find out the antibacterial activity and phytochemical analysis of whole plant extracts (shoot, flower, and root) of Vinca rosea.
Methods: In recent work, phytochemicals were extracted from various parts of the plants using various solvents ethyl acetate (ETOAC), ethanol (ETOH), and dimethyl sulfoxide (DMSO). These phytochemicals contain alkaloids, terpenoids, tannins, flavonoids, aminoacids, saponins, aromatic acids, phenolic compounds, triterpenoids, xantho proteins, PHILOBATININS, carbohydrate, reducing sugar, and proteins; and they were separated by the standard methods. Moreover, antimicrobial activities of methanolic separation were determined by a different species of bacteria and fungi. Agar well-diffusion method was used for the antimicrobial activity, and also analyzed the zone of inhibition.
Results: The evaluation of phytochemical screening of extracts indicated the existence of alkaloids, terpenoids, tannins, flavonoids, aminoacids, saponins, aromatic acids, phenolic compounds, triterpenoids, xantho proteins, philobatinins, carbohydrate, reducing sugar, and proteins. All the tested bacteria and fungi were controlled efficiently, and the activities of the shoot extracts were better compared to flower and root extracts. ETOH extract of the shoot exhibited highest antifungal activity against Candida albicans, (17.34 mm), followed by Candida krusei (16.12 mm), Aspergillus niger (15.76), Mucor sp. (14.67 mm), and Rhizopus oryzae (13.46 mm), ETOH extract of the shoot exhibited highest antibacterial activity), when compared to flower and root extracts against Staphylococcus aureus (12.77 mm), followed by Pseudomonas aeruginosa (11.67 mm), Salmonella abony (10.23 mm), Escherichia coli (9.65 mm), Micrococcus luteus (8.95 mm. V. rosea shoot extracts highlighted effective antifungal activities compared with flower and root extracts against all the tested bacteria.
Conclusion: Current studies have shown that the V. rosea plant contains significant antimicrobial activities in the ETOH extracts. The strong antifungal and antibacterial activities of V. rosea are owing to the presence of saponin, tannins, and flavonoids present in.
A VALIDATED ANALYTICAL METHOD FOR THE SIMULTANEOUS ESTIMATION OF CYTARABINE AND DAUNORUBICIN IN BULK AND INFUSION FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: PRASANTHI CHENGALVA  , LATHA LAVANYA PEDDAVENGARI  , MADHAVI KUCHANA  
Published: December 2019

Objective: The novel liposomal infusion formulation of cytarabine and daunorubicin liposomal infusion is considered as new hope in acute myeloid leukemia treatment. The objective of the present study is to develop and validate a simple, rapid, accurate, precise and sensitive reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous estimation of cytarabine and daunorubicin in bulk and infusion formulation.
Methods: The chromatographic separation of the drugs was achieved on Denali C18 (250 mm×4.6 mm, 5 μm) in isocratic mode with mobile phase consisting of water (pH was adjusted to 3):acetonitrile in the ratio of 55:45 with a flow rate of 1 ml/min at a detection wavelength of 240 nm using photodiode array (PDA) detector. The column temperature was set at 30°C with 10 μl injection volume. The proposed method was validated as per the International council for Harmonisation (ICH) guidelines.
Results: The retention times for cytarabine and daunorubicin were found to be 2.323±0.12 min and 3.140±0.16 min, respectively. Linearity (r2=0.999) was observed over a concentration range of 16.2–97.5 μg/ml for cytarabine and 7.2–43.5 μg/ml for daunorubicin. The percentage relative standard deviation (RSD) for precision studies was found to be 0.2 for both the drugs.
Conclusion: A simple, rapid, economic, accurate, and precise RP-HPLC method was developed for simultaneous quantitative estimation of cytarabine and daunorubicin, and the method was validated as per the ICH guidelines. Hence, the method can be employed for the routine analysis of cytarabine and daunorubicin in bulk and infusion formulation.
ANTIFUNGAL EFFICIENCY OF COPPER OXYCHLORIDE-CONJUGATED SILVER NANOPARTICLES AGAINST COLLETOTRICHUM GLOEOSPORIOIDES WHICH CAUSES ANTHRACNOSE DISEASE
Authors: RAGHAVENDRA SN  , RAGHU HS  , DIVYASHREE K  , RAJESHWARA AN  
Published: December 2019

Objectives: Anthracnose disease is caused by Colletotrichum gloeosporioides, affecting most of the fruit and vegetable plants. The present study is aimed to synthesize silver nanoparticles (AgNPs) using neem extract and conjugate then with fungicide to check the antifungal activity against anthracnose disease.
Methods: In the current study, we have synthesized copper oxychloride-conjugated AgNPs (COC-AgNPs) by a biological method using neem extract and have tested their effectiveness against C. gloeosporioides. The COC-AgNPs were characterized by UV–visible spectroscopy, fourier-transform infrared, scanning electron microscopy, and X-ray diffraction analysis, and in vitro antifungal activity was investigated.
Results: The shape of COC-AgNPs was found to be spherical with an average particle size of 21–25 nm. The fungicide-conjugated AgNPs exhibited highest growth inhibition of C. gloeosporioides (~187%) as compared to fungicide copper oxychloride.
Conclusion: These results indicate that the COC-AgNPs could be effectively used to control anthracnose disease in mango and in other crops. These COC-AgNPs can drastically reduce the amount of fungicide currently used which will reduce the environmental pollution caused by the fungicide.
SYNTHESIS AND OPTIMIZATION OF GEMCITABINE-LOADED MIL-101NH2 (Fe) NANOCARRIERS: RESPONSE SURFACE METHODOLOGY APPROACH
Authors: PREETI KUSH  , JITENDER MADAN  , PARVEEN KUMAR  
Published: December 2019

Objective: The objective of the present study is to synthesize and optimize gemcitabine (GEM)-loaded MIL-101NH2 (Fe) nanocarriers. The design of experiments is used to optimize the formulation for higher encapsulation efficiency (EE) for effective drug delivery.
Materials and Methods: MIL-101NH2 (Fe) was synthesized by microwave-assisted hydrothermal method. Central composite design (CCD) under response surface methodology was used for the optimization of GEM encapsulation into the MIL-101NH2 (Fe). The most influential variable that affects the EE was investigated by Perturbation plot. Validation of the design was carried out by performing the experiments under optimal conditions. Further optimized formulation was physicochemically characterized for particle size, surface charge, and surface morphology using zetasizer and scanning electron microscopy (SEM), respectively. Structural integrity of the optimized formulation was carried out by Powder X ray crystallography (PXRD). Fourier-transform infrared (FTIR) spectroscopy was used for the confirmation of GEM loading. Accelerated storage stability analysis was also performed to find out the related parameters.
Results: Here in this work, crystalline MIL-101NH2 (Fe) has been successfully synthesized by microwave radiation method. The optimization result revealed that process variables such as GEM concentration, pH, and time significantly affect the desired constraint, EE. Perturbation plot evidenced that among all the variables, pH is the most significant factor followed by drug concentration and time. The optimized formulation exhibited 76.4 ± 7% EE and average particle size of 252.9 ± 9.23 nm. PXRD and SEM results demonstrated that the optimized formulation was crystalline in nature. FTIR spectroscopy confirms the presence of drug inside the MIL-101NH2 (Fe). In vitro release profile revealed that MIL-101NH2 (Fe)-GEM exhibited the sustained release up to 72 h in comparison to the native GEM. Storage-stability studies also indicate that MIL-101NH2 (Fe)-GEM has a shelf life of 6 months.
Conclusion: The EE of GEM in MIL-101NH2 (Fe) can be altered by varying the drug concentration and pH during the impregnation.
Development and validation of Spectrophotometry methods for estimation of linezolid in bulk and in pharmaceutical Dosage formulation
Authors: Mali Rink R. , Gorle A.P. 
Published: December 2019

A simple, precise and economical, and rapid Spectrophotometric methods for the quantification of Linezolid in bulk material and in tablets. Further, this study is designed to validate the developed methods as per ICH guidelines. Material & methods: In Methods A and B, a stock standard solution was prepared by dissolving 10 mg of Linezolid in 100 mL of phosphate buffer pH 7.4 to obtain a concentration of 100 μg/mL. After suitable dilution, 10 μg/mL of Linezolid was prepared and scanned in the UV-visible range 400 –200 nm; In method A zero order spectrum Linezolid showed a maximum absorbance at 251 nm. while in Method B area under curve (AUC) zero-order spectrum was recorded between 245 and 268 nm. For a linearity study, series of dilutions were prepared from stock solutions. Results: In Method A and B, Linezolid followed linearity in the concentration range of 3 – 18 μg/mL with (r2 = 0.9978) (r2 = 0.9981). The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120%. The % recovery was found to be in the range 96.15% – 99.32% for method A, while in method B range is 99.16 % - 100.20 %. The low values of % RSD are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method was precise. Ruggedness of the proposed method was studied with the help of two analysts. The proposed method of pharmaceutical formulation the amounts of Linezolid estimated by both these methods (A and B) were found to be 96.25 ± 0.44 and 99.48 ± 1.05, respectively. Conclusion: The developed methods are simple, precise, rugged, and economical. Both these methods can be used for routine analysis of Linezolid from its tablet formulation.
Keywords: Linezolid, UV-Spectrophotometric methods, area under curve, zero order spectrum
Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Authors: Gorle Ashish , Mahajan Jayashri , Bhave Prathamesh 
Published: December 2019

Desoximetasone chemically is 9-fluoro-IIβ21-dihydroxy-I6a-methylpregna-I.4-diene-3.The precise mechanism of the anti-inflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. So, in present investigation chromatographic methods were developing use RP-HPLC for estimation of Desoximetasone in bulk and in cream formulation and method validation according to ICH guidelines. The main objective of this study was to develop a simple and reproducible method for desoximetasone by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). In this work the desoximetasone separation was carried out by using C18 cosmosile column (250mmx4.6mm particle size 5µm). By using 0.1% orthrophosphoric acid pH adjusted up to 3 at uv detection of 240nm.The mobile phase was used at various ratio for gradient elution the ratio of mobile phase was 20:80 v/v. Methanol and water used for mobile phase and flow rate was being set at 1mL/min. The linearity of proposed method was found in range of r =0.9989. Statistically validation parameters such as linearity, accuracy, precision, LOD and LOQ were checked.
Keywords: Desoximetasone, RP-HPLC, Method validation.
Analysis of minerals under different water stress levels in Andrographis paniculata (Burm.f.) Wall. Ex Nees
Authors: Bhargavi Bhattu , Kalpana Kaloori , Kistamma S 
Published: December 2019

Medicinal plants have diverse use in the society from medicine to cosmetics to herbal foods with vast potential for their curative medicinal properties. Minerals are essential nutrient for plant metabolism and over all growth of the plants. The overall growth of the plant depends upon the availability of the water. The aim of this study was to determine the mineral content under different water stress levels in Andrographis paniculata. The homogenized leaf samples of controlled plants(Daily watered), treated T2 plants(watering 2nd day), T4 plants(watering on every 4th day), T7 plants(watering on every 7th day) were subjected to overnight HN03 digestion and analyzed for the presence of Copper, Chromium, Iron, Aluminum, Zinc, Manganese and Phosphorous. With increase in water stress, element content deceased with varied fractions. The T2 treated plants, irrigated every second day, could withstand the water stress conditions without affecting minimum mineral content in Andrographis paniculata plants and T2 treatment has been chosen the best option to withstand water stress conditions.
Keywords: Andrographis paniculata, water stress, minerals.
The determinant of sustainable consumption behaviour of Moslem woman in Sukoharjo
Authors: Prastiwi Septi Kurnia , Rabia Rabia 
Published: December 2019

ABSTRACT
As the increasing of the public consumption pattern, it is followed by environmental pollution offset, which is increasingly alarming. This study aims to analyze how sustainable consumption behavior of Muslim women mediates the intention to behave. Two variables that are thought to influence the sustainable consumption behavior are environmental value and environmental sensitivity by mediating behavioral intention. This study uses a survey method with a population of Muslim mothers in the Sukoharjo area, a sample of 100 respondents, with sampling using a purposive technique, namely judgment sampling, and questionnaires with 12 indicator indicators. The results of the validity, reliability, and classical assumption tests support the continuing research. Results from the path analysis show that the variable â€˜environmental sensitivityâ€™ has a significant effect on behavioral intention and sustainable consumption behavior. Hypothesis test results show that environmental values â€‹â€‹have a positive and significant effect on behavioral intention and sustainable consumption behavior. The results of the sobel test show that behavioral intention can mediate the relationship between environmental values â€‹â€‹and the sustainable consumption behavior.
Tailoring the Weights on Objective versus Subjective Performance Measures between Top Management and Middle Managers: Evidence from Performance-Based Equity Incentive Plans
Authors: Chen Clara Xiaoling , Gao Yongjing , Wang Yue , Xue Shuang 
Published: December 2019

ABSTRACT
This study examines the determinants of performance measurement tailoring between top management and middle managers in compensation contracts. Theoretically, while tailoring potentially enhances the informativeness of performance measures for top management and middle managers respectively, it may reduce the incentives for the two parties to coordinate with each other. We expect a firm's decision to tailor performance measurement between top management and middle managers to be driven by this cost-benefit trade-off. Using hand-collected data from performance-based equity incentive plans from Chinese public firms, we find evidence consistent with the predictions derived from our theoretical framework. Specifically, we find that the likelihood that a firm tailors the weights on objective versus subjective performance measures between top and middle managers increases with competition intensity, non-price competition, environmental uncertainty, and CEO power, and decreases with organizational stability and growth opportunity. Furthermore, we find that suboptimal tailoring decisions are associated with higher management turnover.
Hubungan Interaksi Sosial Bentuk Akomodasi Guru-Siswa dengan Hasil Belajar Sosiologi Siswa SMAN 3 Padang
Authors: Efriman Efriman , Junaidi Junaidi 
Published: December 2019

Penelitian ini dilatarbelakangi karena ketertarikan peneliti melihat hasil belajar siswa di SMA Negeri 3 Padang yang rendah akibat namun interaksi sosial yang terjadi antara guru dengan siswa berjalan dengan baik dan semestinya. Penelitian ini bertujuan untuk mengetahui hubungan antara interaksi sosial (akomodasi) dengan hasil belajar Sosiologi siswa SMA Negeri 3 Padang. Penelitian dianalisis dengan teori yang dikamukakan oleh Gegne dan Berliner. Di dalam penelitian ini digunakan suatu pendekatan kuantitaif Ex-Post Facto, teknik pemilihan proportional random sampling dan jumlah responden yang diambil 58 orang. Data sekunder dalam penelitian berupa hasil belajar dan dokumentasi yang dianalisis dengan menggunakan analisis data deskriptif data, pengumpulan data dilakukan dengan cara penyebarkan angket. Hasil dalam penelitian ini dapat dilihat bahwa terdapat yang signifikan dalam korelasi antara variabel interaksi sosial (akomodasi) dengan hasil belajar Sosiologi siswa SMA Negeri 3 Padang dibuktikan dengan koefisien korelasi (rxy) 0, 459 > rtabel 0, 256.
Tecnologías del capitalismo contemporáneo para el Entretenimiento y el Diseño de almas ¿estandarizadas?
Authors: Azcurra Mariani Ana Clara 
Published: December 2019

En este trabajo nos proponemos un acercamiento exploratorio a las charlas TED (TED Talks), producto audiovisual alojado en la plataforma YouTube y la web ted.com de gran circulación y consumo. Frente a un actual régimen de acumulación flexible que parcela las voluntades y las responsabilidades vitales de manera individual, explorar críticamente las características de TED nos acerca a los patrones actitudinales actuales frente al conocimiento y la acción política.
TED parece ofrecer un producto a tono con el hedonismo nihilista al que se refiere Mark Fisher (2016), ese no pensar que se apropia de discursos rápidos y digeridos que permiten ostentar un supuesto conocimiento multidisciplinar e ilustrado. Una profundización en su formato puede iluminar intersecciones discursivas menos innovadoras de las que su apariencia indica, y lo suficientemente conservadoras en sus valores basales. En este sentido, el artículo se expande sobre cómo las famosas charlas funcionan como estructura en sintonía con las lógicas culturales del capitalismo contemporáneo, para luego avanzar sobre cómo incorporan a oradores que tensionan el formato por sostener lugares de enunciación y de origen subalternos.
Problemas geopolíticos y sociales en América Latina
Authors: Noemí. B. Mellado  
Published: December 2019

Desde finales del siglo pasado se asiste a la reconfiguración y multiplicación de instancias de concertación, cooperación e integración; sin embargo, en la actualidad existen una serie de cuestionamientos y reclamos de índole social de diversa naturaleza.
Dichas demandas marcan la necesidad de establecer una agenda vinculada a materias que van desde una mayor equidad en la distribución del ingreso hasta el reconocimiento de derechos personales como la igualdad de género y la violencia hacia la mujer, generando replanteos en la gestión de los distintos niveles gubernamentales.
Att säga som det är
Authors: León Rosales René 
Published: December 2019

In this article the author analyses how boys in upper secondary schools do identity work and masculinities mainly through verbally performing acts of both intolerance and tolerance in group discussions. The analytical focus highlights how both tolerance and intolerance are actualized in balancing acts that are based on an awareness of what is perceived to be linked to one or the other, and how identities are constructed through discursive resources and specific performances resulting in the production of masculinities. This performative balancing act is conceptualized as (in)tolerance as a masculine performance.
Fenómeno de la migración escolar en la universidad surcolombiana
Authors: Amaya García Karol Stefanía , Córdoba Muñoz Laura , López Jiménez Nelson Ernesto 
Published: December 2019

El Grupo de investigación PACA - Categoría A de Colciencias ha adelan­tado investigaciones en torno al fenómeno de la permanencia escolar", en ellos se ha identificado una problemática relacionada con el estado particular entre el abandono y la perrnanencia", la cual se ha denomi­nado: migración escolar.
Este fenómeno es entendido como el cambio de programa académico que realiza el estudiante universitario en la misma institución, después de haber cursado un número determinado de semestres.