bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factor analysis for progressive spinal deformity after resection of intracanal tumors─a retrospective study of 272 cases
Authors: Wang Pangbo , Author) Kang Ma(Former Corresponding , Chen Tunan , Xue Xingsen , Ma Dada , Wang Shi , Chen Xin , Meng Hui , Cui Gaoyu , Gao Boyuan , Lin Jiangkai , Feng Hua , Author) Weihua Chu(New Corresponding 
Published: October 2019

Abstract
Abstract
OBJECTIVE: Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative spinal stability remain to be further research. Here, we described the current largest series of risk factors analysis for progressive spinal deformity following resection of intracanal tumors.
METHODS: We retrospectively analyzed the medical records of the patients with resection of intracanal tumors between January 2009 and December 2018. All patients who underwent resection of intracanal tumors performed regular postoperative follow-up were identified and included in the study. Clinical, radiological, surgical, histopathological, and follow-up data were collected. The incidence of postoperative progressive kyphosis or scoliosis was calculated. The statistical relationship between postoperative progressive spinal deformity and radiographic, clinical, and surgical variables was assessed by using univariate tests and multivariate logistic regression analysis.
RESULTS: Two hundred seventy-two patients (mean age 42.56 ± 16.18 years) with median preoperative modified McCormick score of 3 met the inclusion criteria. Among them, 7（2.6%）patients were found to have spinal deformity preoperatively, and the extent of spinal deformity in these 7 patients deteriorated after surgery. 36 (13.2%) were new cases of postoperative progressive deformity. The mean duration of follow-up was 21.8 months (median 14 months, range 6–114 months). In subsequent multivariate logistic regression analysis, age≤18 years (p=0.027), vertebral levels of tumor involvement (p = 0.019) and preoperative spinal deformity(p=0.008) was the independent risk factors (p < 0.05), increasing the odds of postoperative progressive spinal deformity by 3.94- , 0.69- and 27.11-fold, respectively.
CONCLUSIONS: The incidence of postoperative progressive spinal deformity was 15.8%, mostly in these patients who had younger age (≤18 years), tumors involved in multiple segments and preoperative spinal deformity. The risk factors of postoperative progressive spinal deformity warrants serious reconsideration that when performing resection of spinal cord tumors in these patients with such risk factors, the surgeons should consider conducting follow-ups more closely, and when patients suffering from severe symptoms or gradually increased spinal deformity, surgical spinal fusion may be a more suitable choice to reduce the risk of reoperation and improve the prognosis of patients.
Limbal-conjunctival Autograft Transplantation Versus Conjunctival Autograft Transplantation In The Treatment Of Pterygium: A Self-control Study
Authors: Wang Tianyu , Gu Yifan , Zhang Yi , Pan Lu 
Published: October 2019

Abstract
Background : Pterygium is a common ocular growth, which affects vision, ocular surface function, and aesthetics of the eye. Although various surgical methods are used for treating pterygium, there has been no consensus on the most suitable method. Therefore, it is important to choose the most appropriate and effective surgical method for the treatment of pterygium. The aim of this study was to compare the characteristics and efficacy of limbal-conjunctical autograft transplantation and conjunctival autograft transplantation for the treatment of pterygium. Methods : From August 2015 to December 2016, 80 patients with bilateral primary pterygium in Minhang Hospital affiliated to Fudan University were treated with limbal-conjunctival autograft transplantation in one eye (group A) and conjunctival autograft transplantation in the fellow eye (group B). The operative times of the two surgical methods were compared. The corneal epithelial healing times and recurrence rates for the two methods were observed and recorded after two years of follow-up. Results : Eight patients dropped out of the study and 72 patients participated in the final evaluation. The average operative time for group A and group B was 27.56 1.48 minutes and 26.91 1.39 minutes, respectively. There was no significant difference between the operative times for the two groups (t = 1.93, P = 0.058). The average corneal epithelial healing time for groups A and B was 2.56 0.34 days and 4.85 0.49 days, respectively (t=25.26, P < 0.001). Two years after the surgery, pterygium recurred in two eyes (2.78%) in group A and in nine eyes (14.29%) in group B. The difference between the two groups was statistically significant (2=4.82, P=0.028). Conclusion : In primary pterygium surgery, the healing time of the corneal epithelium after limbal-conjunctival autograft transplantation is shorter than that after conjunctival autograft transplantation, and the pterygium recurrence rate after limbal-conjunctival autograft transplantation is lower than that after autologous conjunctival transplantation. Although both limbal-conjunctival autograft transplantation and conjunctival autograft transplantation can achieve good clinical results, limbal-conjunctival autograft transplantation is superior to conjunctival autograft transplantation in terms of the corneal epithelial healing time and recurrence rate of pterygium after surgery.
Evaluating a digital tool for supporting breast cancer patients: a randomised controlled trial protocol (ADAPT)
Authors: Lidington Emma , McGrath Sophie , Noble Jillian , Stanway Susannah , Lucas Amanda , Mohammed Kabir , Graaf Winette van der , Husson Olga 
Published: October 2019

Abstract
Background: There is a growing number of mHealth tools for breast cancer patients but a lack of scientific evidence for their effects. Recent studies have shown a mix of positive and negative impacts on users. Here we will assess the impact of OWise Breast Cancer, a mobile application for self-monitoring symptoms and managing care, on the process of self-management. Methods: This randomised controlled trial with early-stage breast cancer patients will assess the effect of OWise use on patient activation at 3 months from diagnosis measured by the PAM-13 questionnaire. We will also assess differences in changes in health-related quality of life, psychological distress, health status and NHS health resource utilisation over the first year from diagnosis. Participants will be randomly allocated (1:1) to standard care or standard care plus OWise. Participants will complete questionnaires before starting anti-cancer treatment and at 3 months, 6 months and 12 months from diagnosis. Clinical and patient-reported outcome data will be linked to health resource utilisation data from Discover, an integrated care record of primary, secondary and social care in North West London. We will measure contamination in the control group and adjust the sample size to mitigate the dilution of effect estimates. A per protocol analysis will be conducted as a sensitivity analysis to assess robustness of the primary results. Discussion: This study aims to generate evidence for the effectiveness of OWise at improving patient activation for women with early-stage breast cancer. The results will show the impact of using the tool at the patient level and the NHS health system level. The outcomes of the study will have implications for the application of OWise across the NHS for breast cancer patients and expansion into other tumour types. Assessing publicly available mHealth tools poses a challenge to trialists due to the risk of contamination. Here we apply various methods to measure, mitigate and assess the effects of contamination. Trial registration: The study was registered at clincaltrials.gov (NCT03866655) on 7 March 2019.
Physiological and transcriptomic analyses reveal the mechanisms underlying the salt tolerance of Zoysia japonica Steud.
Authors: Wang Jingjing , An Cong , Guo Hailin , Yang Xiangyang , Chen Jingbo , Zong Junqin , Li Jianjian , Liu Jianxiu 
Published: October 2019

Abstract
Soil salinization areas are sparsely populated and have fragile ecosystems, which seriously restricts the sustainable development of local economies. Zoysia grasses are recognized as excellent warm-season turfgrasses worldwide, with high salt tolerance and superior growth in saline-alkali soil. However, the mechanism underlying the salt tolerance of Zoysia remains unknown. In our study, we investigated the phenotypic and physiological responses of two contrasting materials, Zoysia japonica Steud. Z004 (salt sensitive) and Z011 (salt tolerant), to salt stress. The results showed that Z011 exhibited stronger salt tolerance than Z004, with a higher K + /Na + ratio in both its leaves and roots. To further study the molecular mechanisms underlying salt tolerance, we compared the transcriptomes of the two materials at different time points (0 h, 1 h, 24 h, and 72 h) and from different tissues (leaves and roots) under salt treatment. The 24-h time point and roots were identified as the significant time point and tissue. According to the GO and KEGG analyses of different comparisons, the key DEGs participating in the salt-stress response were selected and belonged to the hormone pathway, TF families and the DUF family. The interaction between the key DEGs was discussed, revealing that auxin signal transduction and TF families may cooperate in Zoysia salt tolerance and that the WRKY family may be the most important TF family. Thus, our research provides fundamental information regarding the salt-stress response in Zoysia and enhances the understanding of molecular mechanisms in salt-tolerant plants.
Physiological response of Miscanthus x giganteus grown in nutritionally poor post-military soil
Authors: Malinská Hana , Pidlisnyuk Valentina , Nebeská Diana , Erol Anna , Medžová Andrea , Trögl Josef 
Published: October 2019

Abstract
Background: To determine the level of plant stress of second-generation biofuel crop Miscanthus x giganteus ( Mxg ) grown in poor quality post-military soils using physiological parameters; to identify impact of plant growth regulators (PGRs) on the stress reduction and to select the fluorescence indicators most suitable for quantification of stress. Plant fitness was quantified with non-invasive measurement of leaf fluorescence using 16 different indexes. Simultaneously visible stress signs were observed on stems and leaves and differences were revealed by microscopy of leaf sections. Results: Leaf fluorescence analysis, visual observation and changes of leaf anatomy revealed significant stress in all tested subjects . Besides commonly used F v /F m and P.I. (performance index), the fluorescence parameter T fm (time to achieve maximum fluorescence) seems to be rather sensitive and applicable for revealing finer differences. However, none of investigated parameters proved significant positive effect of PGRs on stress reduction. Conclusions: Measuring F v /F m , P.I., and T fm is a suitable method for revealing stress affecting Mxg in poor post-military soils. Since PGRs application did not reduce the stress level, direct application of soil amendments should be considered for stress reduction and improving the biomass quality.
Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies
Authors: Gong Hai-bo , Gao Shu-tao , Pu Xiong-ming , Kang Xiao-jing , Wu Xiu-juan 
Published: October 2019

Abstract
Background: To date, The pathological mechanisms underlying the occurrence and development of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. This study aimed to investigate the association between TNFAIP3 and TNIP1 gene polymorphisms with psoriasis susceptibility.Methods Comprehensive literature search was undertook across four online databases—PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) up to August 25, 2019. Allele model of inheritance was used to analyze the original data. Newcastle–Ottawa scale (NOS) was used to evaluate the risk bias of each study. Pooled odds ratios and 95% confidence intervals were calculated using the RevMan 5.3 software.Results In all, 13 case-control studies comprising 13,908 psoriasis patients and 20,051 controls were identified and included in this meta-analysis. The results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random effect model (G vs. T, OR = 1.19, 95% CI: 1.09–1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed effect model (A vs. G, OR = 1.69, 95% CI:1.58–1.80, P < 0.00001).Conclusions This meta-analysis indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.
The Effect Of Sleeping Position On Heart Rate Variability In Newborns
Authors: Fister Petja , Nolimal Manca , Lenasi Helena , Klemenc Matjaž 
Published: October 2019

Abstract
Background : Lower heart rate variability (HRV) in a newborn might represent a risk factor for unfavourable outcome, a longer recovery after illness, and a sudden infant death. Our aim was to determine whether the newborn’s sleeping position is associated with HRV. Methods : We performed a prospective clinical study in 46 hospitalized cardiorespiratory term stable newborns. During sleeping, we measured the parameters of HRV in four body positions (supine, supine with tilt, prone, prone with tilt). Results : The TP (total power spectral density) was significantly higher when lying supine in comparison to prone (p = 0,048) and to prone with tilt (p = 0,046). The HF (high frequency of power spectral density) in the supine position without tilt tended to be higher compared to prone without tilt (p > 0,05). The LF (low frequency power) was significantly higher when lying supine compared to prone, both without tilt (p = 0,018). TP and HF showed a positive correlation with postmenstrual age (PMA) (p = 0.044 and p = 0.036, respectively). Conclusions : In term newborns, sleeping position is associated with HRV. Higher TP and HF were found in the supine position, which might reflect better ANS stability. PMA positively correlated with TP and HF power, but only in supine position.
Application of group LASSO regression based Bayesian networks in risk factors exploration and disease prediction for acute kidney injury in hospitalized patients with hematologic malignancies
Authors: Li Yang , Chen Xiaohong , Wang Yimei , Hu Jiachang , Shen Ziyan , Ding Xiaoqiang 
Published: October 2019

Abstract
Background: This study aims to explore the associated risk factors of acute kidney injury (AKI) in patients with hematologic malignancies (HM) by Bayesian networks (BN), to assess the prediction ability of BN model, and to deduce the probability of AKI under different conditions through BN reasoning. Methods: From 1 October, 2014 to 30 September 2015, 2501 hospitalized patients diagnosed with HM in Zhongshan Hospital, Fudan University, Shanghai of China, were recruited in this retrospective study. Data of demographics, comorbidities, and clinical lab records were exported from the electronic medical records. The candidate features for AKI was screened and selected out by group LASSO (gLASSO) regression, and the inter-relationship between the featured risk factors was presented in BN. Results: Among 2395 eligible patients, 370 cases were diagnosed with AKI (15.4%). AKI incidences in patients with multiple myeloma (24.1%) and leukemia (23.9%) were the highest while the lowest rates were in lymphoma (13.4%). The gLASSO regression indicated that age, gender, diabetes, hemopathy category, anti-tumor treatment, hemoglobin, serum creatinine (SCr), estimated glomerular filtration rate (eGFR), serum uric acid, serum sodium and potassium level on admission had a significant association with the incidence of hospitalized AKI. BN model revealed complex correlations between these related factors, in which a direct connection between age, hemoglobin, eGFR, serum sodium and potassium and AKI was found. HM category and anti-tumor treatment were indirectly linked to AKI through hemoglobin and eGFR, while diabetes was connected with AKI through sodium. Inferences by BNs found that when poor GFR, anemia and hyponatremia, probability occur simultaneously, the probability of AKI may reach 78.5%. The area under the receiver operating characteristic curve of BN is 0.843 (95% CI: 0.812 to 0.858), shared a satisfactory prediction ability. Conclusion: AKI is common among inpatients with HM, affected by multiple risk factors. Bayesian networks combined with gLASSO can provide a novel strategy to explore the potential risk factors integrally and deep into their interrelationships, in accordance with the tide of e-alert and big-data of early detection and prevention of AKI.
Path analysis of skin cancer preventive behaviors in rural women based on protection motivation theory
Authors: Kaviani Abdol-Hossain , Khorsandi Mahboobeh , Roozbahani Nasrin 
Published: October 2019

Abstract
Background: Determining factors affecting adopting preventive behaviors of skin cancer is helpful in designing interventions promoting these behaviors. The present study was conducted aimed to analyze preventive behaviors’ path of skin cancer in rural women based on protection motivation theory. Methods: In this cross-sectional study, 230 rural women in the west of Iran were selected randomly. Data were collected by a valid and reliable questionnaire including demographic information and structures of protection motivation theory by interview with rural women and then analyzed using SPSS 22 and LISREL8.8. Results: In relation with skin cancer preventive behaviors, 27.8% of women were dressed up when working under the sun, 21.7% used sunscreen cream, 5.7% wore cap and 4.8 wore gloves and sunglasses. Protection motivation theory and per capita income explained 76% of motivation variance and 25% of the variance of skin cancer preventive behaviors. Response efficacy structure was the strongest predictor of the motivation of protection (0/001> p, ß= -0.44) and per capita income (0/001> p, ß= -0.34) and motivation (0/001> p, ß= -0.33) were the strongest predictors of these behaviors. Conclusions: This study showed that protection motivation theory is efficient in predicting preventive behaviors of skin cancer and promoting interventions of the behaviors can be designed and implemented by this theory. It is also necessary to perform proper planning in promoting these behaviors in people with low per capita income.
Application of endoscopy in the diagnosis of hepatobiliary tumor in patients with hepatolithiasis
Authors: Xie Jiaming , Li Wei , Feng Zhenyu , Ye Zhenyu , Pan Jun , Du Peng , Ma Xiaoming , Gao Dekang , Wei Shaohua , Chen Wei 
Published: October 2019

Abstract
Background: Hepatobiliary tumor is related to hepatolithiasis, early diagnosis and radical resection determines the prognosis. However, to accurate diagnose early hepatobiliary tumor is difficult. Here we evaluated the value of endoscopy in the diagnosis of hepatobiliary tumor in patients with hepatolithiasis. Methods: Clinical data of 56 patients undergoing choledocholithotomy in the Second Affiliated Hospital of Soochow University from January 2018 to April 2019 were analyzed introspectively. The mucosa morphology, submucosal vascular density and distortion of the hepatobiliarry tracts were observed by choledochoscopy. For the abnormal mucosa, the mucosal properties were further determined from the following aspects: methylene blue or Narrow band imaging(NBI) staining observation of the mucosa, detection of the submucosal structures with the ultra-fine ultrasonic probe under the choledochoscopy, and biopsy of the mucosa. Endoscopic findings of intraoperative hepatobiliary mucosa were verified by biopsy or postoperative pathology results. Results: Choledochoscopy or ultra-fine choledochoscopy was performed on 56 patients with hepatolithiasis, hepatobiliary mucosa was observed then. Among the 56 patients, we found five patients with hepatolithiasis complicated with hepatobiliary tumor, either benign or malignant (8.93%): one case of early cholangiocarcinoma; one case of invasive cholangiocarcinoma; Three cases of hepatobiliary adenomas. one was cholesterol polyp of the gallbladder with local adenomatous hyperplasia of the glands, one was multiple adenomas of the intrahepatic and extrahepatic bile ducts with low-grade intraepithelial neoplasia, and another one was adenomatous hyperplasia of the intrahepatic ducts. Corresponding cholangioscopic images and postoperative pathology results were obtained in all cases. Conclusions: Intraoperative cholangioscopic exploration can accidentally find tumors of the hepatobiliary system besides calculi. Endoscopic staining and observation of the hepatobiliary mucosa under direct vision has important clinical significance and value in the screening of diseases associated with calculi of the hepatobiliary system like hepatobiliary tumors, especially the early cancer of the hepatobiliary tracts.
Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting
Authors: Arnao Valentina , Cinturino Antonio , Mastrilli Sergio , Buttà Carmelo , Maida Carlo , Tuttoomondo Antonino , D'Amelio Marco 
Published: October 2019

Abstract
Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia.Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals.Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed.Results 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN significantly correlated with age, LED, levodopa and SCOPA-AUT scores.Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect a circadian overall sympathetic and parasympathetic disarrangement.