bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis
Authors: Bortolasci Chiara C , Marx Wolfgang , Walker Adam J , Hasebe Kyoko , Kavanagh Bianca E , Morris Margaret J , Mohebbi Mohammadreza , Turner Alyna , Gray Laura , Berk Lesley , Walder Ken , Berk Michael , Dean Olivia M 
Published: March 2020

IntroductionDue to the anti-inflammatory, antioxidant and anti-apoptotic properties of minocycline, clinical trials have evaluated the potential of this drug to treat several psychiatric and neurological disorders, including major depressive disorder, schizophrenia, bipolar disorder, stroke and amyotrophic lateral sclerosis. This protocol proposes a systematic review (and potential meta-analysis) that aims to identify and critically evaluate randomised controlled trials of minocycline for treating psychiatric and neurological disorders.Methods and analysisPubMed, Embase, Cochrane Central Register of Controlled Clinical Trials, PsycINFO and Cumulative Index to Nursing and Allied Health Literature (CINAHL) will be used to identify randomised controlled trials that used minocycline to treat psychiatric and neurological disorders. Double-blind, randomised, controlled, clinical trials of participants aged 18 years or older and written in English will be included in the review. Data will be extracted by two independent reviewers. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will be followed and the Cochrane Collaboration’s ‘Risk of Bias’ tool will be used to assess the risk of bias in all studies included in the systematic review. The Grading of Recommendations, Assessment, Development and Evaluation system will be used to access the overall quality of the level of evidence of the studies. If sufficient evidence is identified, a meta-analysis will be conducted using the standardised mean difference approach and reported with 95% CIs. Heterogeneity of evidence will be evaluated using the I2model.Ethics and disseminationThis systematic review will evaluate only published data; therefore, ethical approval is not required. The systematic review will be published in a peer-reviewed journal and presented at relevant research conferences.Trial registration numberCRD42020153292.
Immediate effects of muscle energy technique and stabilization exercise in patients with chronic low back pain with suspected facet joint origin: A pilot study
Authors: Wahyuddin Wahyuddin , Vongsirinavarat Mantana , Mekhora Keerin , Bovonsunthonchai Sunee , Adisaipoapun Rachaneewan 
Published: March 2020

Background: Facet joint is a potential structure to be the source of chronic low back pain (LBP) affecting lumbar motion, pain, and disability. Other than the recommended treatment of lumbar stabilization exercise (LSE), several manual procedures including muscle energy technique (MET) are commonly used in physical therapy clinic. However, little evidences of the effects of MET have been reported. Objective: This study aimed to compare the immediate effects of MET and LSE in patients with chronic LBP with suspected facet joint origin. Methods: Twenty-one patients with low back pain were recruited and randomly assigned to receive treatment either MET or LSE. The outcomes were kinematic changes, pain intensity, and disability level. Lumbar active range of motion (ROM) of flexion, extension, left and right lateral flexion, and left and right rotation were evaluated using the three-dimension motion analysis system at baseline and immediately after treatment. Pain intensity was evaluated using visual analogue scale (VAS) at baseline, immediately after, and two days after treatment. Thai version of the modified Oswestry disability questionnaire (ODQ) was utilized at baseline and two days after treatment. The mixed model analysis of variance was used to analyze all outcomes. Results: The results showed that all outcomes were not different between groups after treatments. Although there were statistically significant improvements after the treatments when collapsing the groups, the minimal clinically important change was found only for pain but not for lumbar movements and disabilities scores. Conclusion: The effect of MET and LSE alone in single session might not be intensive enough to improve movements and decrease disability in patients with chronic LBP with suspected facet joint origin.
The purpose of punctuation
Authors: Yaffe Philip 
Published: March 2020

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.
Language is ever changing as geographic boundaries morph and populations age. So-called grammar rules can often be arbitrary. Good writing sometimes means using punctuation and sometimes not.
CORP: Assessing author compliance with data presentation guidelines for manuscript figures
Authors: Keehan Kara Hansell , Gaffney Michelle C. , Zucker Irving H. 
Published: March 2020

The present study was undertaken to address the concern that author compliance with American Physiological Society (APS) journal instructions to authors for data presentation in manuscript figures is inadequate. Common instances of noncompliance are omitted molecular weight markers for immunoblots and bar graphs lacking individual data points. The American Journal of Physiology-Heart and Circulatory Physiology ( AJP-Heart and Circ) editorial team designed a program to assess figure data presentation in submitted manuscripts. The intended outcome was to improve author compliance with APS data presentation guidelines and to improve overall rigor and reproducibility in articles published in AJP-Heart and Circ. The AJP-Heart and Circ team invited 37 peer reviewers to participate in a figure reviewer project (FRp). Over a period of five months, 32 first-revision manuscripts were enrolled in the FRp. Each manuscript was reviewed by the original peer reviewers and an additional figure reviewer (FR). Post-peer review, corresponding authors and FRs were surveyed for insight into their experiences. Of the 32 corresponding authors invited, 20 (63%) responded to the survey. In response to the survey, 100% of respondents stated that peer review was performed in a timely fashion despite the additional FR. When asked whether the FR experience had any effect on how one would present data in manuscript figures in future submissions, 65% of authors and 83% of FRs said yes. In addition, 63% of authors responding agreed that the overall quality of their figures was improved after revising based on FR comments. This exercise resulted in improved compliance with APS data presentation guidelines and changed attitudes among both authors and reviewers as to the need for consistent and clear data presentation in manuscript figures. NEW & NOTEWORTHY The goal of the American Journal of Physiology-Heart and Circulatory Physiology figure reviewer program was to improve author compliance with existing APS data presentation instructions for manuscript figures. The result was an improvement in compliance with these guidelines. Time from submission to final decision did not significantly increase for papers with the additional figure reviewer, and both figure reviewers and corresponding authors reported positive feedback in post-program surveys.
Guidelines for animal exercise and training protocols for cardiovascular studies
Authors: Poole David C. , Copp Steven W. , Colburn Trenton D. , Craig Jesse C. , Allen David L. , Sturek Michael , O’Leary Donal S. , Zucker Irving H. , Musch Timothy I. 
Published: March 2020

Whole body exercise tolerance is the consummate example of integrative physiological function among the metabolic, neuromuscular, cardiovascular, and respiratory systems. Depending on the animal selected, the energetic demands and flux through the oxygen transport system can increase two orders of magnitude from rest to maximal exercise. Thus, animal models in health and disease present the scientist with flexible, powerful, and, in some instances, purpose-built tools to explore the mechanistic bases for physiological function and help unveil the causes for pathological or age-related exercise intolerance. Elegant experimental designs and analyses of kinetic parameters and steady-state responses permit acute and chronic exercise paradigms to identify therapeutic targets for drug development in disease and also present the opportunity to test the efficacy of pharmacological and behavioral countermeasures during aging, for example. However, for this promise to be fully realized, the correct or optimal animal model must be selected in conjunction with reproducible tests of physiological function (e.g., exercise capacity and maximal oxygen uptake) that can be compared equitably across laboratories, clinics, and other proving grounds. Rigorously controlled animal exercise and training studies constitute the foundation of translational research. This review presents the most commonly selected animal models with guidelines for their use and obtaining reproducible results and, crucially, translates state-of-the-art techniques and procedures developed on humans to those animal models.Listen to this article’s corresponding podcast at: https://ajpheart.podbean.com/e/guidelines-for-animal-exercise-and-training-protocols/ .
Targeting Fatty Acid Oxidation to Promote Anoikis and Inhibit Ovarian Cancer Progression
Authors: Sawyer Brandon T. , Qamar Lubna , Yamamoto Tomomi M. , McMellen Alexandra , Watson Zachary L. , Richer Jennifer K. , Behbakht Kian , Schlaepfer Isabel R. , Bitler Benjamin G. 
Published: March 2020

Abstract

Epithelial-derived high-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy. Roughly 80% of patients are diagnosed with late-stage disease, which is defined by wide-spread cancer dissemination throughout the pelvic and peritoneal cavities. HGSOC dissemination is dependent on tumor cells acquiring the ability to resist anoikis (apoptosis triggered by cell detachment). Epithelial cell detachment from the underlying basement membrane or extracellular matrix leads to cellular stress, including nutrient deprivation. In this report, we examined the contribution of fatty acid oxidation (FAO) in supporting anoikis resistance. We examined expression Carnitine Palmitoyltransferase 1A (CPT1A) in a panel of HGSOC cell lines cultured in adherent and suspension conditions. With CPT1A knockdown cells, we evaluated anoikis by caspase 3/7 activity, cleaved caspase 3 immunofluorescence, flow cytometry, and colony formation. We assessed CPT1A-dependent mitochondrial activity and tested the effect of exogenous oleic acid on anoikis and mitochondrial activity. In a patient-derived xenograft model, we administered etomoxir, an FAO inhibitor, and/or platinum-based chemotherapy. CPT1A is overexpressed in HGSOC, correlates with poor overall survival, and is upregulated in HGSOC cells cultured in suspension. CPT1A knockdown promoted anoikis and reduced viability of cells cultured in suspension. HGSOC cells in suspension culture are dependent on CPT1A for mitochondrial activity. In a patient-derived xenograft model of HGSOC, etomoxir significantly inhibited tumor progression.

Implications:
Targeting FAO in HGSOC to promote anoikis and attenuate dissemination is a potential approach to promote a more durable antitumor response and improve patient outcomes.
Carotid Artery Stenosis Is Associated with Better Intracranial Collateral Circulation in Stroke Patients
Authors: Pienimäki Juha-Pekka , Sillanpää Niko , Jolma Pasi , Protto Sara 
Published: March 2020

<b><i>Background:</i></b> Adequate collateral circulation improves the clinical outcome of ischemic stroke patients. We evaluated the influence of ipsilateral carotid stenosis on intracranial collateral circulation in acute stroke patients. <b><i>Methods:</i></b> We collected the data of 385 consecutive acute stroke patients who underwent mechanical thrombectomy after multimodal computed tomography (CT) imaging in a single high-volume stroke center. Patients with occlusion of the first segment (M1) segment of the middle cerebral artery were included. We recorded baseline clinical, laboratory, procedural, and imaging variables and technical, imaging, and clinical outcomes. The effect of carotid stenosis on intracranial collateral circulation was studied with appropriate statistical tests and ordinal regression analysis. <b><i>Results:</i></b> Fifty out of the 247 patients eligible for analysis had severe ipsilateral carotid stenosis (≥75%). These patients were 4-times more likely to have very good intracranial collaterals (Collateral Score 3–4, <i>p</i> = 0.001) than the nonstenotic and slightly stenotic (&#x3c;75%) patients. The severely stenotic patients had a longer mean operation time (41 vs. 29 min to reperfusion, respectively, <i>p</i> = 0.001). Nevertheless, 54% of severely stenotic patients had good 3-month clinical outcome (modified Rankin Scale ≤2) with no significant difference between the 2 groups. <b><i>Conclusions:</i></b> Carotid artery stenosis of over 75% of vessel diameter was associated with better intracranial collateral circulation of patients with acute ischemic stroke. This did not significantly change the 3-month clinical outcome.
Calculation of Prognostic Scores, Using Delayed Imaging, Outperforms Baseline Assessments in Acute Intracerebral Hemorrhage
Authors: Lun Ronda , Yogendrakumar Vignan , Demchuk Andrew M. , Aviv Richard I. , Rodriguez-Luna David , Molina Carlos A. , Silva Yolanda , Dzialowski Imanuel , Kobayashi Adam , Boulanger Jean-Martin , Gubitz Gordon , Srivastava Padma , Roy Jayanta , Kase Carlos S. , Bhatia Rohit , Hill Michael D. , Dowlatshahi Dar 
Published: March 2020

Background and Purpose—
Patients with intracerebral hemorrhage (ICH) are often subject to rapid deterioration due to hematoma expansion. Current prognostic scores are largely based on the assessment of baseline radiographic characteristics and do not account for subsequent changes. We propose that calculation of prognostic scores using delayed imaging will have better predictive values for long-term mortality compared with baseline assessments.

Methods—
We analyzed prospectively collected data from the multicenter PREDICT study (Prediction of Hematoma Growth and Outcome in Patients With Intracerebral Hemorrhage Using the CT-Angiography Spot Sign). We calculated the ICH Score, Functional Outcome in Patients With Primary Intracerebral Hemorrhage (FUNC) Score, and modified ICH Score using imaging data at initial presentation and at 24 hours. The primary outcome was mortality at 90 days. We generated receiver operating characteristic curves for all 3 scores, both at baseline and at 24 hours, and assessed predictive accuracy for 90-day mortality with their respective area under the curve. Competing curves were assessed with nonparametric methods.

Results—
The analysis included 280 patients, with a 90-day mortality rate of 25.4%. All 3 prognostic scores calculated using 24-hour imaging were more predictive of mortality as compared with baseline: the area under the curve was 0.82 at 24 hours (95% CI, 0.76–0.87) compared with 0.78 at baseline (95% CI, 0.72–0.84) for ICH Score, 0.84 at 24 hours (95% CI, 0.79–0.89) compared with 0.76 at baseline (95% CI, 0.70–0.83) for FUNC, and 0.82 at 24 hours (95% CI, 0.76–0.88) compared with 0.74 at baseline (95% CI, 0.67–0.81) for modified ICH Score.

Conclusions—
Calculation of the ICH Score, FUNC Score, and modified ICH Score using 24-hour imaging demonstrated better prognostic value in predicting 90-day mortality compared with those calculated at presentation.
The Masculinity of Jeremiah
Authors: Asikainen Susanna 
Published: March 2020

Abstract
Although the majority of the Hebrew Bible prophets are men, their masculinity has rarely been examined. This article analyzes the masculinity of Jeremiah vis-à-vis traditional hegemonic ideals of masculinity. These ideals include sexual, physical, and inner strength as well as authority and persuasive speech. The book of Jeremiah values these traditional ideals but Jeremiah himself is not a hegemonically masculine man. He does not exhibit sexual strength since he is not married and has no children. He lacks masculine authority when he does not succeed in persuading his opponents. Whereas God shows masculine physical strength, Jeremiah does not defend himself against his opponents. Jeremiah also lacks inner strength when he complains to God in his so-called confessions.
Conserving Wolves by Transforming Them? The Transformative Effects of Technologies of Government in Biodiversity Conservation
Authors: Stokland Håkon B. 
Published: March 2020

Abstract
This article investigates the construction of instruments and techniques employed in the management of Norwegian wolves since the early 1980s by construing the tools as technologies of government. The proliferation of such instruments and techniques, constructed to effect protection in practice, has transformed Norwegian wolves in significant ways. Unlike the historic population, which often went through large variations in numbers and was spread throughout large parts of the country, the current population of wolves is regulated to stay at a fixed number and within a relatively small wolf-zone. The current population is also highly amenable to detailed government; the number and location of the wolves, and even the genetic composition of the population over the longer term, can be reconfigured in detail. The article further argues that the general proliferation of governmental technologies in biodiversity conservation has meant similar transformations of a great number of endangered organisms.
Attitude Analysis of Child-Constructed Scenes Depicting Human Interactions with Unpopular Nonhuman Animals
Authors: Zhbanova Ksenia S. , Leffler Jeffrey L. , Rule Audrey C. 
Published: March 2020

Abstract
This study tested a tool that could reveal children’s attitudes toward unpopular nonhuman animals through a content analysis of constructed clipart scenes arranged and described by elementary students. Pictures were analyzed for clipart choices, pictorial themes, themes of attitudes toward nonhuman animals, and other components of verbalized statements. Most (79%) students created scenes showing humans standing surrounded by animals. Boys made more statements concerning weapons, traps, or poison and about performing violent actions against animals than girls. Girls made more statements about liking animals than boys. Ecologistic, naturalistic, humanistic, moralistic, and aesthetic themes (displaying “feminine” attitudes) were more common in the female participants’ verbalizations, while scientistic, utilitarian, dominionistic, negativistic, and neutralistic themes (displaying “masculine” attitudes) occurred more frequently in the male explanations. Both genders exhibited similar levels of “feminine” attitudes, but boys exhibited more “masculine” attitudes than girls.
Hidden for Their Protection
Authors: Decker Andrea 
Published: March 2020

Abstract
Dangdut, Indonesia’s most popular music genre, is a realm of gender contestation. Since the 1990s, the role of professional dangdut singer—once equally filled by men and women—has been dominated by women. In an atmosphere of increasing Islamic fervour, pious consumption, and moral panic, the public perception of gender and sexuality has serious implications for men who sing dangdut on television. Regardless of their gender identity and sexual orientation, male singers must prove themselves to be properly gendered to maintain their positions as entertainers. However, proper masculinity is a difficult target to hit, especially considering the gender diversity of off-air and backstage realities. Men use several tactics to boost perceptions of masculinity and acceptability. One way in which men who sing dangdut endeavour to prove themselves cowok banget, or super manly, is by employing symbols of Islam and the Middle East—filtered through an Indonesian lens—to communicate masculinity.
Pop Culture as Argument and Aspiration
Authors: Fox Richard 
Published: March 2020

Abstract
The scholarship on post-authoritarian Indonesia has taken a relatively passive attitude to theorizing popular culture—either presupposing the category absolutely, or invoking prior theorists as authorities without querying the coherence or applicability of their accounts and terminology. As the contributions to this special issue mean to suggest, the question of popular culture may require more careful consideration—not least given its alleged importance for our understanding of recent developments in politics, religion and the economy. This introductory essay provides a brief synopsis of the articles and a survey of the key issues addressed.
All-Inside Repair of Bucket-Handle Meniscal Tears: Clinical Outcomes and Prognostic Factors
Authors: Ardizzone Carolyn A. , Houck Darby A. , McCartney Derek W. , Vidal Armando F. , Frank Rachel M. 
Published: March 2020

Background: There is no consensus on technique of choice for repair of bucket-handle meniscal tears (BHMTs). Purpose: To determine factors that affect patient outcomes and failure rates in patients undergoing all-inside repairs of BHMTs. Study Design: Systematic review. Methods: A systematic review of 3 databases using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed. All English-language literature from 1993 to 2019 describing clinical outcomes for patients undergoing all-inside BHMT repair with ≥12-month follow-up was reviewed by 2 independent reviewers. Patient characteristics (patient sex, age), intraoperative factors (laterality, concomitant procedures, surgical technique, implants utilized), and postoperative outcomes (failure rates) were analyzed. Study quality was evaluated with the Modified Coleman Methodology Score (MCMS). Results: Fifteen studies (1 level 1, 4 level 3, 10 level 4) with 763 total patients (64% male; average age, 26.4 years [range, 9-58 years]; average follow-up, 39.8 months [range, 12-120 months]) including 396 all-inside BHMT repairs were included. Six devices were used for repair including the Meniscal Repair System, FasT-Fix, Meniscus Arrow, Biofix Arrow, RapidLoc device, and PDS II suture, with failure rates of 13.5%, 22.4%, 27.1%, 42.9%, 45.2%, and 0%, respectively. The overall repair failure rate was 29.3% at an average of 13.0 months (range, 5.0-32.4 months), but 19.0% for devices still in use. The RapidLoc and Biofix Arrow had higher failure rates than other devices ( P = .0003). Women (31%) were less likely to experience a failure than were men (69%) ( P = .03). Longer follow-up duration resulted in higher failure rates (>30 months, 34.4%; <30 months, 23.4%; P = .016). In 4 studies reporting on both all-inside and inside-out repairs, no significant differences in failure rates were observed. No significant differences in failure rates were found between medial and lateral repairs nor repair with and without concurrent anterior cruciate ligament reconstruction ( P > .05 for all). The overall average MCMS was 54.4 ± 12. Conclusion: The overall failure rate after all-inside repair of BHMTs is 29.3% at an average of 13.0 months, with no difference in failure rates between medial and lateral meniscal repairs. The variables shown to negatively affect the failure rates were the RapidLoc and Biofix Arrow, male sex, and longer follow-up duration.