bluuebunny/crossref_metadata_2025_split huggingface dataset:
Color‐Selective Printed Organic Photodiodes for Filterless Multichannel Visible Light Communication
Authors: Strobel Noah , Droseros Nikolaos , Köntges Wolfgang , Seiberlich Mervin , Pietsch Manuel , Schlisske Stefan , Lindheimer Felix , Schröder Rasmus R. , Lemmer Uli , Pfannmöller Martin , Banerji Natalie , Hernandez‐Sosa Gerardo 
Published: February 2020

AbstractFuture lightweight, flexible, and wearable electronics will employ visible‐light‐communication schemes to interact within indoor environments. Organic photodiodes are particularly well suited for such technologies as they enable chemically tailored optoelectronic performance and fabrication by printing techniques on thin and flexible substrates. However, previous methods have failed to address versatile functionality regarding wavelength selectivity without increasing fabrication complexity. This work introduces a general solution for printing wavelength‐selective bulk‐heterojunction photodetectors through engineering of the ink formulation. Nonfullerene acceptors are incorporated in a transparent polymer donor matrix to narrow and tune the response in the visible range without optical filters or light‐management techniques. This approach effectively decouples the optical response from the viscoelastic ink properties, simplifying process development. A thorough morphological and spectroscopic investigation finds excellent charge‐carrier dynamics enabling state‐of‐the‐art responsivities >102 mA W−1 and cutoff frequencies >1.5 MHz. Finally, the color selectivity and high performance are demonstrated in a filterless visible‐light‐communication system capable of demultiplexing intermixed optical signals.
New Findings on an Old Question: Can Defect‐Free Graphene Monolayers be Superior Metal‐Ion Battery Anodes?
Authors: Wu Donghai , Yang Baocheng , Chen Houyang , Ruckenstein Eli 
Published: February 2020

AbstractGraphene has numerous extraordinary properties and applications, ranging from water purification to energy storage. Previous studies identified that defect‐free graphene monolayers cannot be adopted as lithium‐ion battery anodes. Approaches, such as functionalization and introducing defects in graphene, have been employed to improve its performance in energy storage. However, defects in graphene boost dendrite growth, resulting in safety issues and fast power losses in batteries. Herein, by adopting state‐of‐the‐art first‐principles calculations, orbital theory, and transition state theory, it is found that defect‐free graphene monolayers are a promising potassium‐ion battery (KIB) anodes, however, they cannot be employed as lithium‐/sodium‐/magnesium‐/calcium‐/zinc‐/aluminum‐ion battery anodes. The evidence of adsorption energy and electron transfer indicates that van der Waals interactions dominate the adsorption of K atoms while delocalized electrons neutralize repulsion between K ions. The KIB anode delivers a high capacity of 1487.7 mA h g−1 and ultrafast charging/discharging rates. Transition state theory results demonstrate that its ultrahigh classic diffusion constants achieve 2.36 × 1011/1.55 × 109 s−1, its Wigner zero‐point‐energy‐/tunneling‐corrected diffusion constants approach 2.38 × 1011/1.56 × 109 s−1, and its low quantum‐mechanical tunneling effects are 0.67%/0.72% under the low/high concentration diffusion of K ions at room temperature. This work offers a more comprehensive understanding of defect‐free graphene.
Thermally Durable Nonfullerene Acceptor with Nonplanar Conjugated Backbone for High‐Performance Organic Solar Cells
Authors: Cho Hye Won , An Na Gyeong , Park Song Yi , Shin Yun Seop , Lee Woojin , Kim Jin Young , Song Suhee 
Published: February 2020

AbstractA nonfullerene acceptor (NFA) with acceptor–donor–acceptor (A–D–A) architecture, i‐IEICO‐2F, based on 4,9‐dihydro‐s‐indaceno[1,2‐b:5,6‐b′]dithiophene as an electron‐donating core and 2‐(6‐fluoro‐2,3‐dihydro‐3‐oxo‐1H‐inden‐1‐ylidene)‐propanedinitrile as electron‐withdrawing end groups, is designed and synthesized. i‐IEICO‐2F has a twist structure in the main conjugated chain, which causes blueshifted absorption and leads to harmonious absorption with a high bandgap donor. The bandgap of i‐IEICO‐2F compliments the bandgap of suitable wide bandgap donor polymers such as J52, leading to complete light absorption throughout the visible spectrum. Devices based on i‐IEICO‐2F exhibit optimized photovoltaic performance including an open‐circuit voltage of 0.93 V, a short‐circuit current density of 16.61 mA cm−2, and a fill factor of 73%, and result in a power conversion efficiency (PCE) of 11.28%. The i‐IEICO‐2F‐based devices reach PCEs of >11% without using any additives or post‐treatments. Devices are found to be thermally stable and maintain 44% of their initial PCE after 184.5 h of continuous thermal annealing (TA) treatment at 150 °C. Based on UV, atomic force microscopy (AFM), and grazing incidence wide angle X‐ray scattering (GIWAXS) results, i‐IEICO‐2F devices show almost identical morphology and molecular orientation throughout the TA treatment and excellent stability compared to other IEICO derivatives.
Imaging Carrier Dynamics and Transport in Hybrid Perovskites with Transient Absorption Microscopy
Authors: Deng Shibin , Blach Daria D. , Jin Linrui , Huang Libai 
Published: February 2020

AbstractIn this review, the recent progress in using transient absorption microscopy to image charge transport and dynamics in semiconducting hybrid organic–inorganic perovskites is discussed. The basic principles, instrumentation, and resolution of transient absorption microscopy are outlined. With temporal resolution as high as 10 fs, sub‐diffraction‐limit spatial resolution, and excited‐state structural resolution, these experiments have provided crucial details on charge transport mechanisms that have been previously obscured in conventional ultrafast spectroscopy measurements. Morphology‐dependent mapping unveils spatial heterogeneity in carrier recombination and cooling dynamics. By spatially separating the pump and probe beams, carrier transport across grain boundaries has been directly visualized. Further, femtosecond temporal resolution allows for the examination of nonequilibrium transport directly, revealing extraordinarily long‐range hot carrier migration. The application of transient absorption microscopy is not limited to hybrid perovskites but can also be useful for other polycrystalline materials in which morphology plays an important role in carrier transport.
Randomized Controlled Trial of a Multilevel Intervention to Address Social Determinants of Refugee Mental Health
Authors: Goodkind Jessica R. , Bybee Deborah , Hess Julia Meredith , Amer Suha , Ndayisenga Martin , Greene R. Neil , Choe Ryeora , Isakson Brian , Baca Brandon , Pannah Mahbooba 
Published: February 2020

HighlightsMultilevel strengths‐based intervention decreases refugee distress and improves protective factors.Holistic focus on psychological, material, social, educational, and cultural needs is effective.High recruitment/retention rates support importance of non‐stigmatizing universal interventions.Refugee Well‐being Project (RWP) intervention reaches refugees unlikely to access formal mental health services.RWP circumvents typical barriers to services (stigma, trust, linguistic/cultural appropriateness).
Complex interactions underlie racial disparity in the risk of developing Alzheimer's disease dementia
Authors: Xiong Chengjie , Luo Jingqin , Coble Dean , Agboola Folasade , Kukull Walter , Morris John C. 
Published: February 2020

AbstractIntroductionWe aim to determine racial disparities and their modifying factors in risk for Alzheimer's disease (AD) dementia among cognitively normal individuals 65 years or older.MethodsLongitudinal data from the National Alzheimer's Coordinating Center Uniform Data Set on 1229 African Americans (AAs) and 6679 whites were analyzed for the risk of AD using competing risk models with death as a competing event.ResultsMajor AD risk factors modified racial differences which, when statistically significant, occurred only with older age among APOE ε4 negative individuals, but also with younger age among APOE ε4 positive individuals. The racial differences favored AAs among individuals with body mass index (BMI) < 30, but whites among individuals with a high BMI (≥ 30), and were additionally modified by sex, education, hypertension, and smoking status.ConclusionsThe presence, direction, and relative magnitude of racial disparity for AD represent an interactive function of major AD and cerebrovascular risk factors.
Synthesis of Diastereoenriched α‐Aminomethyl Enaminones via a Brønsted Acid‐Catalyzed Asymmetric aza‐Baylis‐Hillman Reaction of Chiral N‐Phosphonyl Imines
Authors: Liu Yangxue , Ahmed Sultan , Qin Xiao‐Yan , Rouh Hossein , Wu Guanzhao , Li Guigen , Jiang Bo 
Published: February 2020

AbstractAn effective chiral GAP methodology for preparing α‐aminomethyl enaminones through a (R)‐CSA‐catalyzed asymmetric aza‐Baylis‐Hillman reaction is reported. Excellent yields and high diastereoselectivity could be obtained under mild conditions and convenient GAP techniques. The confirmations of the absolute configuration of N‐phosphonyl imine and chiral enaminone by X‐ray diffraction provides an explicit explanation of the chirality mechanism for GAP chemistry.
ZIF‐8‐Nanocrystalline Zirconosilicate Integrated Porous Material for the Activation and Utilization of CO2 in Insertion Reactions
Authors: Srivastava Diksha , Rani Poonam , Srivastava Rajendra 
Published: February 2020

AbstractThe conversion of CO2 to useful chemicals, especially to atom economical products, is the best approach to utilize an excess of CO2 present in the atmosphere. In this study, a metal‐organic framework (ZIF‐8) is integrated with nanocrystalline zirconosilicate zeolite to develop an integrated porous catalyst for CO2 insertion reactions. The catalyst exhibits excellent activity for the CO2 insertion reaction of epoxide to produce cyclic carbonate in neat condition without the addition of any co‐catalyst. The catalyst is stable and recyclable during the cyclic carbonate synthesis. Further, the catalyst also exhibits very good activity in another CO2 insertion reaction to produce quinazoline‐2,4(1H, 3H)‐dione.
Bayesian optimal life‐testing plan under the balanced two sample type‐II progressive censoring scheme
Authors: Mondal Shuvashree , Bhattacharya Ritwik , Pradhan Biswabrata , Kundu Debasis 
Published: February 2020

AbstractJoint progressive censoring schemes are quite useful to conduct comparative life‐testing experiment of different competing products. Recently, Mondal and Kundu (“A New Two Sample Type‐II Progressive Censoring Scheme,”Commun Stat‐Theory Methods; 2018) introduced a joint progressive censoring scheme on two samples known as the balanced joint progressive censoring (BJPC) scheme. Optimal planning of such progressive censoring scheme is an important issue to the experimenter. This article considers optimal life‐testing plan under the BJPC scheme using the Bayesian precision and D‐optimality criteria, assuming that the lifetimes follow Weibull distribution. In order to obtain the optimal BJPC life‐testing plans, one needs to carry out an exhaustive search within the set of all admissible plans under the BJPC scheme. However, for large sample size, determination of the optimal life‐testing plan is difficult by exhaustive search technique. A metaheuristic algorithm based on the variable neighborhood search method is employed for computation of the optimal life‐testing plan. Optimal plans are provided under different scenarios. The optimal plans depend upon the values of the hyperparameters of the prior distribution. The effect of different prior information on optimal scheme is studied.
FCX‐146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second‐generation arylidene indanone scaffold
Authors: Balasubramaniam Meenakshisundaram , Lakkaniga Naga Rajiv , Dera Ayed A , Fayi Majed Al , Abohashrh Mohammed , Ahmad Irfan , Chandramoorthy Harish C. , Nalini Ganesan , Rajagopalan Prasanna 
Published: February 2020

AbstractAkt, a serine‐threonine protein kinase, is regulated by class‐I PI3K signaling. Akt regulates a wide variety of cell processes including cell proliferation, survival, and angiogenesis through serine/threonine phosphorylation of downstream targets including mTOR and glycogen‐synthase‐kinase‐3‐beta (GSK3β). Targeting cancer‐specific overexpression of Akt protein could be an efficient way to control cancer‐cell proliferation. However, the ATP‐competitive inhibitors are challenged by the highly conserved ATP binding site, and by competition with high cellular concentrations of ATP. We previously developed an allosteric inhibitor, 2‐arylidene‐4, 7‐dimethyl indan‐1‐one (FXY‐1) that showed promising activity against several lung cancer models. In this work, we designed a congeneric series of molecules based on FXY‐1 and optimized lead based on computational, in vitro assays. Computational screening followed by enzyme‐inhibition and cell‐proliferation assays identified a derivative (FCX‐146) as a new lead molecule with threefold greater potency than the parent compound. FCX‐146 increased apoptosis in HL‐60 cells, mediated in part through decreased expression of antiapoptotic Bcl‐2 protein and increased levels of Bax‐2 and Caspase‐3. Molecular‐dynamic simulations showed stable binding of FCX‐146 to an allosteric (i.e., noncatalytic) pocket in Akt. Together, we propose FCX‐146 as a potent second‐generation arylidene indanone compound that binds to the allosteric pocket of Akt and potently inhibits its activation.
The use of catechins in Chinese hamster ovary cell media for the improvement of monoclonal antibody yields and a reduction of acidic species
Authors: Toronjo‐Urquiza Luis , Acosta‐Martin Adelina E. , James David C. , Nagy Tibor , Falconer Robert J. 
Published: February 2020

AbstractCatechin compounds have potential benefits for recombinant monoclonal antibody (Mab) production as chemical additives in cell culture media. In this study, four catechin compounds catechin (Cat), epicatechin (EC), gallocatechin‐gallate (GCG), and epigallocatechin‐gallate (EGCG) were added to cell culture media (at 50 μM) and their effects on the recombinant Chinese hamster ovary (CHO) cell culture, specific productivity, and Mab quality were assessed. The results indicate that the improvement of specific productivity was linked to cell growth inhibition. All catechins caused cell phase growth arrest by lowering the number of cells in the G1/G0 phase and increasing the cells in the S and G2/M phases. Late addition of the catechin resulted in a significantly higher final IgG concentration. Cat and EC caused an improvement in the final antibody titer of 1.5 ± 0.1 and 1.3 ± 0.1 fold, respectively. Catechins with a galloyl group (GCG and EGCG) arrested cell growth and reduced cell specific productivity at the concentrations tested. The Cat‐treated IgG was found to have reduced acidic species with a corresponding increase in the main peak.
Determination of Carbamates and Thiocarbamates in Water, Soil and Sediment of the Formoso River, TO, Brazil
Authors: Guarda Patricia M. , Pontes Antonina M. S. , de S. Domiciano Raquel , da S. Gualberto Larissa , B. Mendes Danylo , A. Guarda Emerson , da Silva José E. C. 
Published: February 2020

AbstractConsidering the increase in agricultural production in Brazil, the use of pesticides for this production, and that there are no studies on pesticides in the region, the presence of carbamates and thiocarbamates was investigated in different environmental compartments of the Formoso River, TO, Brazil, by UHPLC/MS/MS. The collections were made on the banks of this river, in the area of influence of the agricultural project. The active principles were not found in the soil and sediment samples, only the propoxur principle was found in the water, reaching values of up to 0.025 μg L−1. It was found that the biodiversity of the Tocantinense savannah is under threat, because even though only one of the substances surveyed, propoxur and its derivatives, has been detected, they are substances of high toxicity and tendency to contaminate surface and groundwater to varying degrees and irreversible damage to different species.
The long noncoding RNA LINC00341 suppresses colorectal carcinoma by preventing cell migration and apoptosis
Authors: Li Shuyuan , Chen Shuo , Wang Boxue , Zhang Lin , Su Yinan , Zhang Xipeng 
Published: February 2020

Long noncoding RNAs (lncRNAs) are ubiquitous transcripts that play key roles in regulating gene expression at the levels of transcription, RNA processing, and translation. Aberrant expression and mutations of lncRNAs represent a driving force behind oncogenesis and development of tumours. However, most of the lncRNAs are still being undiscovered, and conclusive experimental evidence for their functional relevance continues to be lacking for most malignancies. We have found that lncRNA long intergenic non–protein‐coding RNA 341 (LINC00341) is aberrantly downregulated by microarray‐based screenings on nonmetastatic and metastatic colorectal carcinoma (CRC) specimens; LINC00341 is a novel long intergenic non–protein‐coding RNA with unknown functions. LINC00341 overexpression restricts tumour growth and promotes its apoptosis. Instead, LINC00341 silencing accelerates CRC cell proliferation and migration. RNA‐pulldown assay identifies LINC00341 physically binds to HMGB2 and stabilizes the localization of HMGB2 in the cytoplasm. Notably, LINC00341 knockdown leads to the shift of HMGB2 into nuclear, in which it triggers epithelial to mesenchymal transition (EMT) programming. Moreover, LINC00341 can also promote apoptosis.Significance of the studyLncRNAs are ubiquitous transcripts that play key roles in regulating gene expression at the levels of transcription, RNA processing, and translation. Aberrant expression and mutations of lncRNAs represent a driving force behind oncogenesis and development of tumours. However, the function of lncRNA still needs further exploration. Our study has revealed a new noncoding RNA‐mediated regulatory network that highly likely protects colorectal carcinoma by preventing migration and apoptosis. The results will help further explore the molecular details about the progression of colorectal carcinoma and stimulate efforts to develop effective therapies.
MicroRNA‐93‐5p expression in tumor tissue and its tumor suppressor function via targeting programmed death ligand‐1 in colorectal cancer
Authors: Chen Yi‐Lin , Wang Gao‐Xiong , Lin Bei‐An , Huang Jing‐Shan 
Published: February 2020

AbstractThis work aimed to investigate miR‐93‐5p expression in tumor tissue and its in vitro effects in colorectal cancer (CRC) by targeting programmed death ligand‐1 (PD‐L1). MiR‐93‐5p and PD‐L1 expression was detected in CRC and adjacent normal tissues by quantitative real‐time polymerase chain reaction and immunohistochemistry. The correlation between miR‐93‐5p and PD‐L1 was validated by a dual‐luciferase reporter assay. HCT116 and SW480 cells were divided into blank, miR‐NC, miR‐93‐5p mimics, miR‐93‐5p inhibitor, PD‐L1 small interfering RNA (siRNA) and miR‐93‐5p inhibitor + PD‐L1 siRNA groups, and wound‐healing and transwell assays were performed to detect cell migration and invasion, respectively. Protein expression was measured by western blotting. The secretion of cytokines was detected in the CRC cell/T coculture models. MiR‐93‐5p was downregulated in CRC tissues with upregulated PD‐L1. In PD‐L1‐negative patients, miR‐93‐5p expression was increased compared with that in PD‐L1‐positive patients. MiR‐93‐5p and PD‐L1 expression levels were associated with the tumor differentiation, lymphatic metastasis, TNM, Duke's stage, and prognosis of CRC. PD‐L1 siRNA weakened the migration and invasion abilities via decreased expression of matrix metalloproteinase‐1 (MMP‐1), ‐2, and ‐9, and these effects were abolished by the miR‐93‐5p inhibitor. Additionally, anti‐PD‐L1 upregulated the expressions of interleukin‐2 (IL‐2), tumor necrosis factor‐α (TNF‐α), and interferon γ (IFN‐γ) in the coculture of T cells with CRC cells, but downregulated the expressions of IL‐1β, IL‐10, and TGF‐β. However, these changes were partially reversed by miR‐93‐5p inhibition. miR‐93‐5p is expected to be a novel target for CRC treatment since it decreases the migration and invasion, as well as the immune evasion, of CRC cells via targeting PD‐L1.
Inhibition of RING1B alters lineage specificity in human embryonic stem cells
Authors: Desai Divya , Khanna Aparna , Pethe Prasad 
Published: February 2020

AbstractPolycomb group (PcG) proteins are histone modifiers which are known to perform transcriptional repression and have been shown to be critical during murine embryonic development. PcGs are broadly characterized into polycomb repressive complex 1 (PRC1) and 2 and (PRC2). RING1B, core catalytic unit of PRC1 performs H2AK119 monoubiquitination leading to transcriptional repression. We used human embryonic stem cell (hESC) line to study the fate of pluripotent stem cells (PSCs) under inhibition of RING1B, as its role in human development is still to be completely explored. Embryoid bodies (EBs) were generated to differentiate hESCs using hanging drop method. PRT4165 (synthetic RING1B catalytic activity inhibitor) was added to undifferentiated and differentiated cells for 24 h. When we inhibited RING1B in undifferentiated cells, OCT4 levels remained unchanged indicating RING1B does not regulate pluripotency. The drug when added to differentiated cells led to decrease in the levels of RING1B, BMI1, and H2AK119ub1. Interestingly, we also report that the differentiated cells show an increased expression of neuroectodermal markers: SOX1 and PAX6 as well as expression of other neuroectodermal markers such as TUJ1, FOXG1, and NCAM. However, there was reduction in expression of endodermal (SOX17 and FOXA2) mesodermal marker BRACHYURY and TBX5 in treated EBs compared with control EBs. In summary, alteration of RING1B catalytic activity in hESCs during differentiation promotes neuroectodermal differentiation thus, we demonstrate critical role of RING1B in regulating neural differentiation. The strategy of inhibiting RING1B could be used to direct PSCs towards early neuronal fate.