bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-linear dynamical feature of center of pressure extracted by approximate entropy in people with various stages of Parkinson’s Disease
Authors: Karimi mohammad , Mirahmadi Mina 
Published: February 2020

Abstract
Introduction : Postural instability, one of the most important features of Parkinson’s Disease (PD), is associated with increased falls and loss of independence in these population. It is postulated the abilities of individuals to adjust to environmental perturbation for postural control is different in various stages of PD. The aim of current study is to investigate the non-linear dynamical feature of COP in various stages of PD and in different environmental challenges. Method : 38 persons with PD (mild PD =19, moderate PD =6 and sever PD =13) and 33 healthy aged, gender, weight and height matched subjects were asked to stand on force plate in four test conditions included: 1) Rigid Surface with Opened Eyes, 2) Rigid Surface with Closed Eyes, 3) Foam Surface with Opened Eyes, and 4) Foam Surface with Closed Eyes. COP velocity and Approximate Entropy (ApEn) in both Anteroposterior (AP)/Mediolateral (ML) directions were calculated. A Mixed ANOVA 4*2*2 (Group*Vision*Surface) test was applied for statistical analysis . Results : Both COP velocity and COP ML ApEn were significantly higher in participants with PD in comparison to healthy individuals. Moreover, COP ML ApEn increased by eye closure in all studied groups but the amount of this increase was lesser in PD groups. For COP velocity, vision, surface and group interaction was significant in all directions (P ≤ 0.016). For COP ApEn, vision, surface and group interaction (P = 0.002) were statistically meaningful in only ML direction. Conclusion : Balance system irregularity is more in people with PD compared to healthy matched individuals. In addition, their adaptive capacity of the postural control system in response to environmental perturbation is reduced. PD induced complexity of the postural control system is associated with the loss of adaptive behavior that is organized over the confluence of constraints of the individual, environment and task.
Inequity of Health-Income Effect in employ workers in China: a longitudinal study from China Family Panel Survey(2012-18)
Authors: XIE Mengxue , Zang Wenbin 
Published: February 2020

Abstract
Background Analyses using classical regression models show that health has significant impact on income. However, in the case of widening income gap, estimating the average effect of health on income would aggregate the inequality of health-income effect for poor workers. Methods Data came from four waves of China Family Panel Survey data from 2012 to 2018. We generalized a balance panel data including worker characteristics, job information and health status. The final sample of our study includes 19,540 person-year observations aged between 18 to 70 years. Panel Quantile Regression method was used to analyse the effect of health on income for workers under different income distribution.Results The regression estimates show that the effects of health on income are larger at 25th and 50th quantile of distributions, 21% and 16.9% respectively. We test the robustness by the heterogeneity of workers’ gender and register living regions, find that health is more important for female workers and rural workers. Last, we find that workers who participated in manual labour were more dependent on their health than those involved in brain work. Conclusions Our findings suggest that the inequality of health-income effect would underestimate the importance of health for lower income workers, especially for poor female and rural ones. In addition, we also find that the mechanism of reduced income effect due to the difference of the employment type.
Quantitative analysis of TMT phosphorylation modification to investigate the effect of verbascoside on the expression of phosphorylated protein in AD cell model
Authors: Haiyan Xing 
Published: February 2020

Abstract
Ethnopharmacological relevance— The active monomer Verbascum glycosides in Cistanche tubulosa has good development prospects in terms of neuroprotection and delaying neurodegenerative diseases, and it has become one of the research hot spots. Aim of the study— To investigate the effect of verbascoside (OC1) on the expression of phosphorylated protein in the protective effect of AD cell model by TMT labeling and phosphorylation enrichment technique and high-resolution liquid chromatography-mass spectrometry quantitative proteomics research strategy. Materials and Methods— The normal control group, the model group (Aβ 1-42 10μmol/L) group and the OC1 administration group (10μg/ml) group were set. (1)protein extraction quality control.(2)TMT mark.(3)HPLC classification and modification enrichment. (4)Analysis of mass spectrometry by liquid chromatography-mass spectrometry. (5)Analysis of bioinformatics results.(6)Western Blotting was used to detect the expression levels of p-CaMKII(Thr286), p-Synapsin (Ser9) / Synapsin, Synaptophysin and Synaptotagmin-1 protein. Results— The study finally identified 9020 phosphorylation sites on 3227 proteins, of which 8635 sites of 3134 proteins contained quantitative information. Screening of differential sites follows the following criteria: 1.2 times the change threshold and CV value < 0.1. Based on the above data and standards, we performed a systematic bioinformatics analysis of proteins containing quantitative information sites. Western Blotting results showed that Verbascoside could promote the expression of p-CaMKII (Thr286), p-Synapsin (Ser9) / Synapsin, Synaptophysin and Synaptotagmin-1 protein. Conclusions— Verbascoside (OC1) can increase the expression of phosphorylated protein in AD cell model, which provides a basis for further study on the molecular mechanism of verbascoside promoting neurotransmitter release.
Associations between perceived environmental pollution and health-related quality of life in a Chinese adult population
Authors: Han Bingxue 
Published: February 2020

Abstract
Background Health-related quality of life (HRQoL) measures are being used in increasingly diverse populations. However, there have no known studies to date to examine the associations between perceived environmental pollution and HRQoL in a Chinese adult population. This study aimed to report the associations between air, water, noise pollution and HRQoL among Chinese populations. Methods A cross-sectional survey data was used from East Asian Social Survey 2010 with a sample of 3866 Chinese populations in environmental pollution. HRQoL was computed by SF-12 and reflected by physical and mental component summary score (PCS & MCS). Ordinary least regression analyses were used to examine associations between perceived environmental pollution and PCS and MCS scores. Models in SPSS PROCESS were selected to demonstrate the moderating and mediating effects. Results Only considering one pollutant, perceived air pollution and perceived water pollution had significant associations with PCS and MCS scores. Perceived noise pollution had significant associations with PCS scores. Perceived air×noise, air×water, noise×water, and air×noise×water pollution had significant associations with PCS and MCS scores. Conditional (moderated) mediation showed that there were no moderating effects and mediating effects of perceived one pollutant on another pollutant. Conclusions Co-occurring perceived environmental pollution were mainly associated with progressive increase in PCS and MCS scores among the Chinese adult population. These results suggested that some effective policies should be carried out to improve environmental quality across Chinese adult population.
How long does a hip-preserving surgery with vascularized pedicle iliac bone grafts for femur head necrosis last? A systematic review and meta-analysis of case series with an average more than 5-year follow-up
Authors: Zhu Xingyang , Zhang Haitao , Sun Xiaobo , Zeng Yuqing , Li Feilong , Chen Jinlun , Deng Peng , Ye Pengcheng , Zeng Yirong 
Published: February 2020

Abstract
Background: Hip-preserving surgeries with vascularized pedicle iliac bone grafts (VPIBG) are effective for osteonecrosis of the femoral head (ONFH). However, few studies exist about the long-term efficacy of this procedure. The aim of this meta analysis was to investigate how long does this hip-preserving surgery last. Methods: A comprehensive search was carried out through PubMed, Embase and Cochrane Collaboration Library for all relevant studies up to November 2019. The literature search strategy contained Medical Subject Headings and terms relating to ONFH and bone transplantation. All included studies were articles on VBIPG for ONFH, with an average follow-up of more than 5 years. Interesting outcomes included clinical success rates, complications, and conversion rates of THA. The data from eligible studies were then extracted and synthesized. The pooled effect size (ES) and 95% confidence intervals (CIs) were calculated. Results: Ten studies were finally selected. Eight studies including 3413 hips were pooled into the meta-analysis of success rates, the overall ES was 0.89 (95% CI, 0.86–0.92). In subgroup analysis, the ES was 0.88 (95% CI, 0.78–0.98) and 0.90 (95% CI, 0.87–0.92) at an average 5-10 years and 10-15 years follow-up, respectively. Pooled analysis of THA conversion rates derived from 7 studies (3389 hips) showed the overall ES of 0.10 (95% CI, 0.09–0.11). Seven studies (3396 hips) were included in a meta-analysis of complication rates, and the overall ES was 0.12 (95% CI, 0.08–0.18). The most common complications were secondary wound healing (37.6%), numbness or paresthesia of the lateral thigh (22.4%), and deep vein thrombosis (19.6%). Conclusions: The hip-preserving surgery with VPIBG is a safe and effective treatment for early-stage ONFH, but it should be used with caution in the treatment of advanced femoral head necrosis. The pooled data from this study suggested that 90% of the hips in patients with ONFH lasted 10 years after this surgery. However, most of the included studies are case series, and these conclusions will need the support of high-quality research in the future.
Midterm outcome analysis of bipolar hemiarthroplasty for unstable intertrochanteric femur fractures: A retrospective study
Authors: CHO Hongman , Kim Sun Do , Park JiYeon , Kwon KiHyun , Lee Young 
Published: February 2020

Abstract
Background: Recent advances in medical systems and technologies have resulted in increased survival after intertrochanteric fractures of the femur, requiring the selection of appropriate femoral stems considering mid- to long-term durations. We performed hip hemiarthroplasty for unstable intertrochanteric fractures using a Wagner cone femoral stem (Group A) and double tapering right angled femoral stem (C2 stem, Group B), and evaluated the clinical imaging results. Methods From January 2004 to December 2013, 79 patients (79 hips) who underwent hip hemiarthroplasty with a cone stem (36 cases) and C2 stem (43 cases) were included. During the follow-up period, clinically, changes in pain (visual analog scale [VAS] score), walking ability, and Harris Hip score were examined. Radiologically, changes in the proximal femur were observed. We also reviewed the complications that occurred. Results Patients’ mean ages were 77.2 (70-83) years and 78.6 (70-84) years, and mean follow-up periods were 84.7 (60-108) months and 85.4 (60-96) years in Groups A and B, respectively. Postoperative pain (VAS score) and the Harris hip score were not significantly different between the groups until 24 months and 36 months, respectively. However, VAS scores from 36 months postoperatively and Harris hip scores from 48 months postoperatively indicated that Group B patients had significantly higher VAS scores and lower Harris hip scores. There was no significant difference in walking ability between the groups; however, in Group B, walking ability was reduced by one grade in 13 patients and by two grades in nine. Cortical bone osteoporosis occurred in four and 14 cases in Groups A and B, respectively. In Group B, five patients developed cortical bone resorption, and four of them had nonunion of trochanteric fracture fragments. Conclusions Hip hemiarthroplasty using a cementless femoral stem for unstable intertrochanteric fractures requires careful selection of the stem, considering the remaining life of the patient. When using a 3C stem for unstable intertrochanteric fractures, it is thought that the firm fixation of fractured trochanteric fragments is necessary, and for a reverse oblique fracture, it is better to use the 3B stem with a suitable length.
Comparison of the gluteus medius strength between obese and eutrophic individuals: a cross-sectional study
Authors: Fenato Rafael Ratti , Araujo Allan Cezar Faria , Guimarães Ana Tereza Bittencourt 
Published: February 2020

Abstract
Background The hip abductor muscles play an important role in stabilizing the pelvis during gait, its main function being performed by the gluteus medius. Gluteus medius insufficiency is associated with biomechanical alterations and musculoskeletal disorders. Due to overweight and a possible muscle mass decrease, maintaining the abductor muscular function can be a great challenge for obese. However, it is still unclear whether the musculature of obese individuals manages to compensate for these alterations. Therefore, the aim of this study was to compare the gluteus medius strength between obese and normal weight individuals using a digital hand-held dynamometer. Methods Twenty-five obese (body mass index > 35 kg / m 2 ) participated in the study, being matched in gender, age, and height with normal weight individuals. The gluteus medius strength was measured by a single examiner using a belt-stabilized hand-held digital dynamometer on the knee of individuals positioned in lateral decubitus. Three measurements were recorded with rest intervals, considering only the highest value measured for each limb for analysis. The difference between pairs was calculated and the data distribution pattern was assessed using the Shapiro-Wilk test (p < 0.05), and the matrices of the variables were standardized and analyzed using the principal component analysis (PCA). Results For the strength variables (Newtons) on both sides, no statistical differences were detected between groups (p > 0.05). However, statistical differences were detected in these variables between groups (p < 0.05) when normalizing the measurements in relation to individuals' weight (Newtons / kilograms). The PCA indicates that both strength in absolute values and normalized by weight are reduced in obese individuals. Conclusions These findings indicate that obese individuals have the same or lower strength (PCA) to move more mass, which may suggest a relative weakness that induces functional limitation.
Early Radiographic and Clinical Outcomes of the Fertilized ACL
Authors: Lavender Chad , Berdis Galen , Singh Vishavpreet , Kopiec adam , Jasko John 
Published: February 2020

Abstract
Background: The aim of this research study is to examine the early radiographic and clinical outcomes as well as the safety of the Fertilized anterior cruciate ligament (ACL) reconstruction procedure. Methods: A total of 14 patents with a mean age of 22.9 (range, 16-45), who had been treated with a Fertilized ACL were evaluated. Clinical outcomes including VAS at 2 and 6 weeks, rate of re-rupture, release to full activity, and incidence of complications were assessed. Radiographic outcomes were assessed through qualified orthopedic surgeons' ability to detect operative features of an ACL reconstruction on patient's ipsilateral tibia radiographs when compared to a standardized set of tibial radiographs. Results: Mean VAS score at 2 weeks and 6 weeks follow up were 1.73 (range, 0-4) and .83 (range, 0-2.5), respectively. There were no cases of rerupture and all patients were returned to activity. One patient underwent a manipulation under anesthesia and diagnostic arthroscopy. There were 0 infections. On radiographic assessment, surgeons correctly identified 58/60 (p<0.05) were correctly identified as having any operative features after undergoing a Fertilized ACL reconstruction. Conclusion: Early pain scores after the Fertilized ACL reveal minimal pain at 2 and 6 weeks and clinical results show no signs of an increased risk compared to standard ACL reconstructions. The early radiographic appearance of the tibial tunnel in the Fertilized ACL technique is more similar to a healthy non-operative tibia than standard ACL reconstructions
Mass Psychogenic Illness in Haraza Elementary School, Tigray, Northern Ethiopia: Investigation to the nature of an Episode.
Authors: Fenta Kiros , Wubayehu Tewolde , Bezabih Nega Mamo , Meles Yrgalem , Mehari Goitom , Abenezar Abenezar , Desta Abraham Aregay , Berhe Asfawosen Aregay , Weldegebriel Ataklti Gebretsadik , Gebru Tesfay Subagadis , Anelo Micheale Jorjo 
Published: February 2020

Abstract
Background Mass psychogenic illness has been documented for more than 600 years in a variety of culture, ethnic, and religious settings. The aim of this study was to assess the nature and characteristics of mass psychogenic illness in Tigray, Northern Ethiopia, Methods School based cross-sectional study was conducted in haraza elementary school from January –February, 2020. Students who were victims of an episode were subjects of the study. A total of twelve students were investigated using semi-structured questionnaire for quantitative study. Seven key informant interviews were conducted using guiding questionnaires. Quantitative data was analyzed using XL sheet while qualitative data was analyzed manually. Result the mean age of study participants was 14 years (SD±1.3). Majority (87%) were teenage female students. The incident was unspecified disease with psychiatric disorder, migraine and syncope with no plausible organic causes. An important feature of migraine and syncope was their co-morbidity with mass psychogenic illness. The community perceived that Evil-devil force and blaming as being an evil-eye were common causes for the occurrence of an episode. Conclusion lack of empirical knowledge and awareness about its management and prevention among community members and health professionals resulted exaggerated rumor that would perceived as newly emerging disease that affected school activities. Integrating MPI in PHEM package at health facility level, advocacy workshops for media and other relevant stakeholders will minimize its impact for the future.
Weighted gene co-expression network analysis identifies potential candidate biomarkers for adenocarcinoma of the esophagogastric junction
Authors: Lai Zhiyong , Yang Wenhui , Li Weibin , Zhang Tiantian , Jia Kai , Jiang Kewei , Xu Jun 
Published: February 2020

Abstract
Background: Gastric cancer (GC) is the fifth most common kind of malignant tumor, and commonly leads to death. As a subtype of gastric cancer, adenocarcinoma of the esophagogastric junction (AEG), accounts for about 50% of all gastric cancer cases. So far, the systematic co-expression analysis of this tumor has not fully explained its pathogenesis. The purpose of this study was to construct RNAs co-expression networks to predict candidate hub genes associated with the tumorigenesis of AEG. Methods: The RNA-seq data of 22 AEG patients was processed with weighted gene co-expression network analysis strategy. Differentiate the modules with clinical tumor markers and preservation, and carry out gene ontology and pathway enrichment analysis. We identified the co-expression modules and used GO and KEGG terms to investigated the functional enrichment of co-expression genes, suggesting that blue and brown modules are related to the biological processes of tumorigenesis. Results: Twenty-five distinct co-expression gene modules were identified, and as the top hub genes of tumorigenic gene modules, CD93, TRIM28, SLC3A2, CBX4, PATL1, and ZNF473 with high intramodular connectivity were assumed as intramodular hub genes in AEG. Conclusion: The weighted gene co-expression network analysis conducted in this study screened out CD93, TRIM28, SLC3A2, CBX4, PATL1, and ZNF473 may act as candidate biomarker in GC and AEG.
Identification and Analysis of the Key Genes associated with the Development from Liver Cirrhosis to Hepatocellular Carcinoma Based on Bioinformatics Analysis
Authors: Li Tianyu , Ding Fang , Yan Huimin 
Published: February 2020

Abstract
Background: Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor, and one of the most common malignant cancer with poor prognosis. Liver cirrhosis is the major risk factor for HCC. The aim of this study was to identify potential key genes associated with the development from liver cirrhosis to HCC and explore their potential mechanisms. Methods: Four microarray datasets GSE17548, GSE63898, GSE25097 and GSE89377 were downloaded from the Gene Expression Omnibus database. A protein-protein interaction (PPI) network was constructed using the STRING database, and potential hub genes were screened using MCODE plug-in in Cytoscape software. The Oncomine database was used to verify the expression of differential genes in cirrhosis and HCC. In order to further verify those hub genes, the hierarchical cluster between normal and HCC tissues was constructed using the UCSC Cancer Genomics Browser. The UALCAN database was used to verify the difference of hub genes in normal and HCC tissues and in different tumor grades. Finally, the cBioPortal online platform was used to analyze the association between the expression of hub genes and prognosis in HCC.Results: A total of 360 DEGs, including 280 downregulated and 80 upregulated genes, were identified. Gene ontology enrichment (GO) analysis showed that these DEGs were mainly enriched in monooxygenase activity, cofactor binding, and oxidoreductase activity (acting on CH-OH group of donors). The mainly enriched pathways were complement and coagulation cascades, prion diseases, and arachidonic acid metabolism. By extracting key modules from the PPI network, 16 hub genes were screened out. In the hierarchical cluster of hub genes between normal and HCC tissues, the results showed that the expression level of 16 hub genes in HCC tissues was significantly higher than that in normal tissues. In addition, expression level of the hub genes was significantly associated with the tumor grades. The survival analysis showed that six hub DEGs, including KIF20A,HMMR, RRM2, TPX2, TTK and UBE2C, were closely associated with the poor prognosis of HCC.Conclusion: Our study discovered six novel potential genes associated with the development from liver cirrhosis to HCC. These key genes may be used as prognostic biomarkers and molecular therapeutic targets for HCC.