bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184
Authors: Osemwenkhae Osaretin P. , Sakuno Takeshi , Hirano Yasuhiro , Asakawa Haruhiko , Hayashi‐Takanaka Yoko , Haraguchi Tokuko , Hiraoka Yasushi 
Published: February 2020

AbstractCdb4 is a protein with unknown functions that binds to curved DNA in vitro in the fission yeast Schizosaccharomyces pombe. Homologues of Cdb4 were identified in a wide range of eukaryotes, including human Ebp1. Both S. pombe Cdb4 and human Ebp1 are nonpeptidase members of the methionine aminopeptidase family. It has been reported that Ebp1 homologues are involved in cell growth regulation and differentiation. However, opposing functions have also been considered and debated upon, and the precise biological functions of this conserved protein are largely unknown. S. pombe cdb4 is a nonessential gene, and no obvious phenotypes have been detected in cells with cdb4 gene deletion. In this study, we identified nup184, encoding a component of the nuclear pore complex, as a gene responsible for the synthetic lethal phenotype associated with cdb4. Furthermore, the synthetic lethal phenotype of Cdb4 was suppressed by over‐expression of human Ebp1, suggesting that it has conserved crucial functions in S. pombe Cdb4 and human Ebp1. This synthetic lethal phenotype associated with Cdb4 and Nup184 provides a molecular genetics tool to study the functions of S. pombe Cdb4 and its conserved members of proteins, including human Ebp1.
Hemoglobins F, A2, and E levels in Laotian children aged 6‐23 months with Hb E disorders: Effect of age, sex, and thalassemia types
Authors: Kingchaiyaphum Benchawan , Sanchaisuriya Kanokwan , Fucharoen Goonnapa , Chaibunruang Attawut , Hess Sonja Y. , Hinnouho Guy‐Marino , Barffour Maxwell A. , Wessells Kimbery R. , Kounnavong Sengchanh , Fucharoen Supan 
Published: February 2020

AbstractIntroductionDetermination of hemoglobins (Hbs) F, A2, and E is crucial for diagnosis of thalassemia. This study determined the levels of Hbs F, A2, and E in children aged 6‐23 months and investigated the effect of age, sex, and types of thalassemia on the expression of these Hbs.MethodsA total of 698 blood samples of Laotian children including 272 non‐Hb E, 271 Hb E heterozygotes, and 155 Hb E homozygotes were collected. Hb profiles were determined using the capillary zone electrophoresis. Coinheritance of α‐thalassemia and the homozygosity for Hb E mutation were checked by PCR‐based assay.ResultsChildren heterozygous and homozygous for Hb E had significantly higher Hb F and A2 levels than non‐Hb E children (median Hb F = 1.1% for non‐Hb E group, 2.7% for Hb E heterozygotes, and 9.4% for Hb E homozygotes; median Hb A2 = 2.6% for non‐Hb E group, 3.8% for Hb E heterozygotes, and 5.2% for Hb E homozygotes). The median Hb E levels were 21.9% for Hb E heterozygotes and 85.3% for Hb E homozygotes. Comparing within group, there was a statistically significant difference between children with and without an α‐gene defect for Hb A2 and E, but not Hb F. Based on a multiple regression analysis, age and sex were significantly associated with the expression of Hb F and A2 but not Hb E.ConclusionsOur findings can guide the development of a diagnostic approach to thalassemia in children aged 6‐23 months.
The analogia fidei in Catholic Theology
Authors: Joseph White Thomas 
Published: February 2020

AbstractThis article explores four components of a Catholic dogmatic conception of the analogia fidei: the intellectual unity of the biblical texts as Scripture, the harmony of the Scriptures and the Church’s doctrinal pronouncements, the unity or analogy between the supernatural mysteries of the faith, and the compatibility and concord of truths of natural reason with truths of divine revelation. This classical conception of divine revelation is compared with alternatives in modern theology, particularly those of Schleiermacher and Rahner, Barth and Balthasar. I argue that, despite their respective strengths, neither modern post metaphysical theological anthropologies nor christological revisions of classical ontology are able to provide the intellectual resources that the traditional Catholic model of the analogia fidei provides, particularly for engaging with distinctively modern questions and contemporary intellectual challenges to Christianity.
‘Only ever as a last resort’: Mental health nurses' experiences of restrictive practices
Authors: Power Tamara , Baker Ashley , Jackson Debra 
Published: February 2020

AbstractNurses play a crucial role in the implementation of restrictive practices such as seclusion and restraint. Restrictive practices have been widely recognized as harmful practices and efforts to reduce their use have been in place for several years. While some reductions have been achieved, more information and insight into the perspectives and experiences of front‐line mental health nursing staff is required if further changes are to be realized. Sixty‐five respondents participated in an online survey to investigate Australian mental health nurses' personal experiences and opinions regarding restrictive practices. Analysis revealed restrictive practices as a complex, contested and challenging area of practice. Analysis of data revealed five main ways that restrictive practices were framed by respondents. These were as follows: as a response to fear; to maintain safety for all; a legacy of time and place; the last resort; and, a powerful source of occupational distress. In addition, findings revealed the need to support staff involved in restrictive practices. This need could be satisfied through the implementation of procedures to address post‐restrictive distress at all levels of the organization. Ensuring an optimal work environment that includes appropriate staffing, availability of supportive education and structured routine debriefing of all episodes of restrictive practice is critical in achieving further reductions in seclusion and restraint.
Using technology and remote support services to promote independent living of adults with intellectual disability and related developmental disabilities
Authors: Tassé Marc J. , Wagner Jordan B. , Kim Minje 
Published: February 2020

AbstractBackgroundThe use of remote support technologies is a newer form of service that can contribute to increased independence while giving adults with intellectual and developmental disabilities a sense of home safety. This research reviewed the use of remote support services, which is a waiver service that includes smart home technologies and remote support staff that can be called upon, when needed.MethodUsing focus groups and telephone interviews, the present authors asked users of remote support services about their experience, including what they liked most and least about their experience with these technologies.ResultsOverall, increased independence and a sense of security and home safety were identified as the two principal benefits. Remote support technologies may be a part of the solution to addressing the lack of direct support professionals available to provide in‐home care.ConclusionsThe present authors discuss the benefits of remote support technologies and offer recommendations for future research regarding remote support technologies and the potential benefits of this newer form of support service.
Blood pressure variability at different time periods within first 24 hours after admission and outcomes of acute ischemic stroke
Authors: Geng Xuyang , Liu Xinyao , Li Fang , Wang Jiamin , Sun Hongwei , Feng Anqi , Sun Yanyan , Sun Hongwei , Yang Fan , Zhao Jingbo , Tang Ying 
Published: February 2020

AbstractThis study discusses the association between blood pressure (BP) variability at different time periods within first 24 hours after admission and the functional outcome in acute ischemic stroke (AIS). We observed BP variability within first 24 hours after admission and evaluated the association between BP variability at different time periods (4 am‐8 am, 10 am‐2 pm, 4 pm‐8 pm, 10 pm‐2 am) and the functional outcome in AIS. National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were applied to evaluate short‐ (7 days) and long‐term functional outcome. The 24 hours after admission and early morning (4 am‐8 am) systolic blood pressure (SBP) variability were associated with poor outcome at day 7 (adjusted OR = 1.567, 95% CI = 1.076‐2.282; adjusted OR = 1.507, 95% CI = 1.028‐2.209, respectively). Compared with the impact of the 24‐hour BP variability on long‐term functional outcome, the early morning SBP was proved to be a strongly independent predictor for functional outcome at 3 months (adjusted OR = 1.505, 95% CI = 1.053‐2.152), 6 months (adjusted OR = 1.560, 95% CI = 1.048‐2.226), and 12 months (adjusted OR = 1.689, 95% CI = 1.104‐2.584). The BP variability in other time period groups was shown to have no influence on functional outcome. In addition, attempts to explain early morning BP variability with baseline characteristic factors at admission found that baseline SBP is the most influential (2.71%) factor. About 95.87% of the SBP variability in early morning was unexplained. In our study, early morning SBP variability is the strongest independent predictor for functional outcome in (AIS) patients, and baseline SBP after admission should be monitored as a control indicator of early morning SBP variability in the treatment of AIS patients.
Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones
Authors: Al‐Kaabi Maysoun A. , Hamdan Farqad B. , Al‐Matubsi Hisham 
Published: February 2020

AbstractAimsTo evaluate plasma kisspeptin‐10 (KP‐10) as a marker for preeclampsia and assess its relation to altered reproductive hormones in preeclamptic pregnant women.MethodsFirst time pregnant women (n = 100) at 20 weeks of gestation participated in this study and divided into preeclamptics (n = 60) and normotensives (n = 40).KP‐10, luteinizing hormone (LH), follicle stimulating hormone (FSH), beta‐human chorionic gonadotropin (β‐hCG), estradiol (E2) and progesterone were evaluated during 2nd and 3rd trimesters of pregnancy for all women.ResultsKisspeptin‐10 levels were reduced in preeclampsia (PE) women compared with normotensive pregnancies. In the 2nd trimester, area under receiver–operator characteristic (ROC) curve was 0.662, positive and negative predictive values were 32.8 and 94.6, and test sensitivity and specificity were 55% and 87.5%, respectively. In the 3rd trimester, area under ROC curve was 0.747 positive and negative predictive values were 22.2 and 97.3, and test sensitivity and specificity were 83.3% and 67.5%, respectively.In PE patients, plasma KP‐10 demonstrated an inverse correlation with E2 (during the 2nd trimester), LH and FSH (during the 3rd trimester), and positively correlated with β‐hCG (during the 3rd trimester).ConclusionThis study showed significantly reduced plasma KP‐10 levels in PE women. This suggests that KP‐10 may play an important role in the pathophysiology of PE. Therefore, combined with previous studies, to diagnose the PE, testing for maternal KP‐10 plasma levels may be useful as an effective screening, but because of low positive predictive value and inadequate test sensitivity, screening cannot be recommended. Furthermore, KP‐10 in PE patients demonstrated significant positive correlation with β‐hCG.
Effects of Written Versus Spoken Production Modalities on Syntactic Complexity Measures in Beginning‐Level Child EFL Learners
Authors: HWANG HAERIM , JUNG HYEYOUNG , KIM HYUNWOO 
Published: February 2020

AbstractLearner corpus studies using syntactic complexity as a construct for characterizing learner proficiency have found that higher proficiency permits learners to produce more complex syntactic structures. However, the majority of previous studies have focused on writing, almost exclusively with adult second language (L2) learners. Given the fundamentally different mechanisms underlying speaking and writing activities, this study investigated (a) how different processes involved in writing and speaking performance affect child L2 learners’ sentence production, and (b) whether syntactic complexity is a better predictor of proficiency in a particular production type. To this end, we analyzed syntactic complexity for written and spoken corpora supplied by native Korean‐speaking child learners of English using 7 syntactic complexity indices. Results showed that learners used longer sentences, more subordination, more verb phrases per T‑unit, and less coordination in writing than in speaking. In addition, a prediction model fitted to the written corpus explained more of the variance in proficiency scores than a model based on the spoken corpus. These findings indicate that the different processes underlying writing and speaking influence the way that beginning‐level child L2 learners produce sentences in writing and speaking tasks.
Immigration Selection and the Educational Composition of the US Labor Force
Authors: Van Hook Jennifer , Bélanger Alain , Sabourin Patrick , Morse Anne 
Published: February 2020

AbstractImmigration policy is often viewed as an important regulator of the flow of labor and human capital into the labor market. In the US context, this perspective underlies efforts to raise the educational levels of newly admitted US immigrants, which has been proposed through a variety of mechanisms. Yet it remains unclear whether and under what circumstances such changes would significantly raise the educational level of the US labor force. We use a microsimulation model to evaluate the effects of various policy proposals that would seek to admit more highly educated immigrants. Results suggest that adopting a Canadian‐style admissions policy that explicitly selects immigrants based on educational attainment would lead to a better educated labor force, especially among immigrants and their descendants. Eliminating all unauthorized immigration or family reunification and diversity admission categories, however, would have minimal impact. Additionally, the effects of all policy scenarios on the educational composition of the entire labor force are likely to be modest and would be conditional on the continuation of intergenerational mobility and high levels of immigration.
Laparoscopic Ladd’s procedure in neonates: A simple landmark detorsion technique
Authors: Pham Hien Duy , Okata Yuichi , Vu Hoan Manh , Xuan Nam Tran , Duc Tam Tran 
Published: February 2020

AbstractBackgroundThe aim of this study was to assess the efficacy of our simple landmark technique for laparoscopic detorsion and the Ladd’s procedure (lap‐Ladd) for malrotation with midgut volvulus in neonates and to identify the risk factors for reoperation after the lap‐Ladd.MethodsWe conducted a retrospective chart review of 42 patients after lap‐Ladd for malrotation between April 2017 and June 2019. Information regarding patient status and intraoperative and postoperative data were analyzed.ResultsThirty‐one patients had volvulus (73.8 %), while 11 patients did not (26.2%). The median age and weight between the two groups at operation were 9 days (range, 3–28 days), 3.2 kg (range, 2–8 kg) and 6 days (range, 2–11), 2.9 kg (range, 2–3.8 kg), respectively. The operative time was significantly shorter in patients with volvulus compared to those without (60 vs 105 min, P = 0.002). Two cases were converted to open surgery because of ischemic changes of the total small intestine during surgery. Reoperation was required in two patients with volvulus (due to adhesive small bowel obstruction and recurrent volvulus). There was no significant predictive factor for reoperation after the lap‐Ladd procedure.ConclusionOur simple landmark lap‐Ladd procedure demonstrated feasibility and good short‐term outcomes in neonates with malrotation, regardless of the presence or absence of volvulus.
Implicit protectionism via state enterprises and technology transfer from foreign enterprises
Authors: Haraguchi Junichi , Matsumura Toshihiro 
Published: February 2020

AbstractWe formulate a mixed triopoly in which one state enterprise competes with one domestic and one foreign private enterprise. The private enterprise can transfer its technology to the private rival, which reduces the rival’s production cost. We show that if the privatization policy is endogenous, then the foreign firm voluntarily transfers its technology. We also show that the foreign enterprise may strategically raise its local ownership share. These results suggest that the existence of a state enterprise and its potential future privatization serve as an industrial policy that improves the domestic firm’s competitive advantage relative to the foreign enterprise.
Prospective teachers anticipate challenges fostering the mathematical practice of making sense
Authors: Keazer Lindsay , Jung Hyunyi 
Published: February 2020

AbstractProblem solving has long been a priority in mathematics education, and the first Common Core mathematical practice (SMP1) focuses on this priority through the language of “Make sense of problems and persevere in solving them.” We present findings from a survey about how prospective elementary teachers' (PTs) make sense of potential difficulties with fostering SMP1. Findings suggested that PTs' common anticipated difficulties relate to planning a solution pathway and self monitoring whether the solution makes sense. Moreover, a third of PTs disclosed that their anticipated difficulties are linked to their own personal struggles with aspects of SMP1. An alternative interpretation of SMP1 surfaced in which a small number of PTs described SMP1 as necessitating that a teacher teach multiple solution methods to students, instead of engaging students in productive struggle to develop their own strategies. We present a framework illustrating the connections between SMP 1 and Pólya's problem solving phases, and we discuss how these findings connect to and build on previous research of PTs' experiences with problem solving. We offer implications for the targeted support needed in teacher preparation programs to address these struggles, to prevent them from being replicated in their students.
Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)
Authors: Pecora Ricardo Augusto , Watanabe Sung Song , Brito Guimarães Marta , Otsuki Denise Aya , de Moraes Barros Paulo Sergio , de Mendonça Vaz Safatle Angélica 
Published: February 2020

AbstractObjectiveOptical coherence tomography (OCT) measurement of adult blue‐fronted parrots (Amazona aestiva), free from infectious, inflammatory or neoplastic systemic diseases and from any ophthalmological illness, aim at its characterization, as well as to standardize the examination technique for the species.ProcedurePupillary dilation was achieved with rocuronium bromide (5 mg/mL) at 0, 2, 15, 17, 30, and 32 minutes. The animals were sedated with midazolam maleate (0.5 mg/kg/IM) and anesthetized with propofol (5.0 mg/kg/IV). Measurements were made to evaluate the thickness of the total retina (TR), sensorineural retinal (SR), and ganglion cell complex (GCC), 2 millimeters (mm) from the pecten toward the fovea. OCT data were compared to measurements of retinal histological slides from enucleated eyes of blue‐fronted parrots, scanned in automatic fluorescence microscope and measured with by the VS‐ASW® software.ResultsAverages of measurements from the 43 retinas evaluated by OCT were TR: 279.40 micrometers (μm), SR: 255.90 μm, and GCC: 138.60 μm, respectively, and the measurements of six retinas using fluorescence microscopy were 260.30 μm for TR, 238.20 μm for SR, and 129.30 μm for GCC, demonstrating a high correlation coefficient between all measurements (r = .8698, P < .0001). It is also possible to evaluate the anatomy of the retina and to identify its layers, variations and abnormalities using OCT images. Variations were found between the different areas of the retina, both in the images of the histological slides and in the images of the OCT.ConclusionOptical coherence tomography is a valuable technique for in vivo evaluation of retinal structures in blue‐front parrots, providing detailed and accurate images. This method improves the understanding of retinal diseases, monitoring the beginning, progression and therapy of retinal diseases, in the same individuals during longitudinal studies. In comparison to histological investigations, OCT enables imaging in vivo, therefore reducing the number of euthanized animals or enucleated eyes.
Predictive Forward Dynamic Simulation of Manual Wheelchair Propulsion on a Rolling Dynamometer
Authors: Brown Colin , McPhee John 
Published: February 2020

Abstract
Research studies to understand the biomechanics of manual wheelchair propulsion often incorporate experimental data and mathematical models. This project aimed to advance this field of study by developing a two-dimensional (2D) model to generate first of its kind forward dynamic fully predictive computer simulations of a wheelchair basketball athlete on a stationary ergometer. Subject-specific parameters and torque generator functions were implemented in the model from dual X-ray absorptiometry and human dynamometer measurements. A direct collocation optimization method was used in a wheelchair propulsion model for the first time to replicate the human muscle recruitment strategy. Simulations were generated for varying time constraints and seat positions. Similar magnitudes of kinematic and kinetic data were observed between simulation and experimental data of a first push. Furthermore, seat heights inferior to the neutral position were found to produce similar joint torques to those reported in previous studies. An anterior seat placement produced the quickest push time with the least amount of shoulder torque required. The work completed in this project demonstrates that fully predictive simulations of wheelchair propulsion have the potential of varying simulation parameters to draw meaningful conclusions.
Hybrid Phase-Change Lattice Boltzmann Simulation of Vapor Condensation on Vertical Subcooled Walls
Authors: Zhao Wandong , Gao Yuan , Li Ruijie , Qiu Songgang , Zhang Ying , Xu Ben 
Published: February 2020

Abstract
Saturated vapor condensation on homogenous and heterogeneous subcooled walls is presented in this study by adopting a hybrid phase-change multiple-relaxation-time Lattice Boltzmann model. The effects of wall wettability on the condensation process, including droplets' growth, coalescence and falling, and the influence of vapor flow to condensation are investigated. The results demonstrate that the heat fluxes around the triple-phase contact lines are higher than that in other cold areas in homogeneous subcooled walls, which actually indicates the fact that filmwise condensation is preventing the continuous condensation process. Furthermore, the dropwise condensation can be formed more easily on the heterogeneous surface with a mixed surface wettability. At last, the dynamic process of condensation of continuous vapor flow is also investigated by considering the homogenous and heterogeneous subcooled surfaces. The results show that the heterogeneous surface with mixed wettability does not significantly contribute to the formation, growth of droplets, when compared to the homogeneous surface. It is expected that this study can bring more attention to simulate condensation using multiphase LBM for complex geometries in heat transfer community.