bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of different scales in the hedonic threshold methodology
Authors: Gamba Mila Marques , Lima Filho Tarcísio , Della Lucia Suzana Maria , Vidigal Márcia Cristina Teixeira Ribeiro , Simiqueli Andréa Alves , Minim Valéria Paula Rodrigues 
Published: July 2020

AbstractThe hedonic threshold methodology (HTM) allows for the determination of the compromised acceptance threshold and the hedonic rejection threshold, using the unipolar nine‐point numbered structured hedonic scale. However, there are other scales that can be used. The aim of this study was to investigate if hedonic thresholds are influenced by the use of different types of hedonic scales. The HTM was applied to grape nectar, varying the sucrose concentration, and to cookies, varying the butter concentration. Four hedonic scales were used: unipolar (“1 to 9”) and bipolar (“−4 to +4”) numbered structured scales and unstructured line (“ULSOC”) and hybrid line scales (“ULSWC”). The “−4 to +4” and “ULSOC” scales were not suitable for use in the HTM, because they do not meet the prerequisite that there is no significant difference between acceptance of the control samples and the first stimulus sample. However, they indicated no significant difference in the second session. This indicates that consumers may have had difficulty understanding and properly using these scales. The “1 to 9” met the prerequisite and presented high discriminant potential. The “ULSWC,” in addition to meeting the prerequisite, showed accuracy and is considered an alternative for the HTM.Practical applicationsThe importance of determining hedonic thresholds covers areas such as food, pharmaceutical, and cosmetic. Industries often need to modify their products, changing as much as possible of a certain characteristic without changing the sensorial acceptance of the product. This occurs when a product is intended to be reformulated by increasing the concentration of desirable substances such as health‐beneficial compounds (e.g., ferrous sulfate and omega‐3) and reducing the concentration of undesirable substances, such as sucrose, sodium, and fat, to promote better health. Quality sensory measurements are increasingly required, given that unreliable data may lead to dreadful decisions as well as long‐lasting financial losses. The hedonic threshold methodology is a recently proposed methodology; therefore, given the differences in the way consumers use scales and the type of response obtained, it is necessary to investigate whether hedonic thresholds are influenced by the use of different scales.
Effects of Orthographic Forms on Second Language Speech Production and Phonological Awareness, With Consideration of Speaker‐Level Predictors
Authors: Bassetti Bene , Mairano Paolo , Masterson Jackie , Cerni Tania 
Published: July 2020

AbstractOrthographic forms (spellings) can affect pronunciation in a second language (L2); however, it is not known whether the same orthographic form can affect both L2 pronunciation and metalinguistic awareness. To test this, we asked 260 speakers of English—first‐language (L1) English speakers, L1 Italian and L2 English sequential bilinguals, and L1 Italian learners of L2 English—to perform word repetition tasks and rhyme judgment tasks for word pairs containing the same consonant or vowel spelled with a letter or a digraph. L1 Italian speakers established a long–short contrast and used consonant and vowel length contrastively in their L2 English, both in production and in an awareness task. This provides evidence for a direct link between the effects of the same orthographic phenomenon on speech production and on metalinguistic awareness. Results were strengthened by combining experimental and qualitative data in the study of orthographic effects. Finally, the results show that proficiency predicts orthographic effects, and that orthographic effect predictors vary in naturalistic and instructed contexts.
Common bottlenose dolphin (Tursiops truncatus) social structure and distribution changes following the 2008 Unusual Mortality Event in the Indian River Lagoon, Florida
Authors: Brightwell Kristin , Titcomb Elizabeth Murdoch , Mazzoil Marilyn , Gibson Quincy 
Published: July 2020

AbstractIn animal societies with fission‐fusion dynamics, demographic disturbances can influence the social and spatial structure of the population. Within the Indian River Lagoon (IRL), Florida, common bottlenose dolphins (Tursiops truncatus) have experienced recurrent unusual mortality events (UMEs) providing an opportunity to examine postdisturbance population and social cluster restructuring. This study investigates the impact of the potentially nonepizootic 2008 UME on the IRL dolphin population. Photo‐identification surveys conducted from August 2006 to May 2010 were stratified into pre‐ (August 2006–April 2008) and post‐UME (September 2008–May 2010) time periods. Social network and spatial (univariate kernel density) analyses were limited to individuals sighted 5+ times per period (pre‐UME = 183, post‐UME = 134), and indicated a change from 11 to ten social clusters, although individuals did not always reassociate with pre‐UME cluster associates. Despite the social and spatial disconnect between IRL proper and Mosquito Lagoon clusters, both network density and core area spatial overlap increased post‐UME allowing for increased intercluster interactions. However, intracluster associations increased as well, allowing the population to maintain multiple social clusters within a loosely connected network. This study shows the important role sociality may play in the adaptability of cetaceans to environmental and demographic changes.
Determinants of nursing students' intention to migrate overseas to work and implications for sustainability: The case of Indonesian students
Authors: Efendi Ferry , Oda Hisaya , Kurniati Anna , Hadjo Samuel S. , Nadatien Ima , Ritonga Imelda L. 
Published: July 2020

AbstractHigh graduation of nurses and limited job opportunities in Indonesia may lead to the emigration of nurses particularly through facilitated migration. This study aimed at identifying the prevalence of Indonesian nursing students with intention to work in Japan and predictors of their intention to migrate as well as having a definite plan to work in Japan. The study adopted cross‐sectional design with a sample of 1,407 Indonesian nursing students. Factors associated with having migration intention, as well as a definite plan to work in Japan, were age, residence, and overseas experience. Other factors related to a definite plan to work abroad were family income, mastering a foreign language, knowledge about the nurse migration related to Indonesia‐Japan cooperation, and their motivations to migrate to Japan. Sustainability of this international recruitment of nurses is possible by understanding the context of both source and destination countries. Maximizing benefits of migration of nurses for Indonesia and Japan requires structured policies targeting the educational sector and addressing the sustainability issues.
Dung mimicry: the function of volatile emissions and corolla patterning in fly‐pollinated Wurmbea flowers
Authors: Johnson Steven D. , Sivechurran Jadine , Doarsamy Sachin , Shuttleworth Adam 
Published: July 2020

Summary

It has been suggested that flowers of some angiosperms mimic vertebrate faeces (dung) in order to exploit insect pollinators that utilize faeces as a source of food and/or oviposition sites.

We investigated a potential case of mimicry in Wurmbea elatior (Colchicaceae), a lily that exhibits a faecal odour and pattern of dark spots on the corolla.

We found that W. elatior is pollinated by a broad assemblage of coprophagous flies and is dependent on pollinator visits for seed production. The flowers emit volatiles that are characteristic of vertebrate faeces, and three of these compounds – skatole, indole, and an unidentified compound – elicited electrophysiological antennal responses from flies. Artificial flowers laced with indole and skatole or skatole alone attracted the same assemblage of flies as was recorded on flowers of W. elatior. Spotted artificial flowers attracted twice as many flies as did those lacking spots. Experimental addition of indole and skatole to flowers of Wurmbea kraussii, a congener with unscented flowers pollinated by hoverflies, induced a shift to an insect visitor assemblage dominated by coprophagous flies.

This study clarifies the roles of volatile emissions (particularly skatole) and visual signals in floral dung mimicry.
Clinical, immunological and genetic findings in patients with UNC13D deficiency (FHL3): A systematic review
Authors: Amirifar Parisa , Ranjouri Mohammad Reza , Abolhassani Hassan , Moeini Shad Tannaz , Almasi‐Hashiani Amir , Azizi Gholamreza , Moamer Soraya , Aghamohammadi Asghar , Yazdani Reza 
Published: July 2020

AbstractBackgroundFamilial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive immune disorder that is caused by mutations in 6 different genes related to the formation and function of secretory lysosomes within cytotoxic T lymphocytes and natural killer (NK) cells. Thus, defect in these genes is associated with the accumulation of antigens due to defective cytotoxic function. FHL type 3 (FHL3) accounts for nearly 30‐40% of FHL, and its underlying reason is mutation in UNC13D gene which encodes Munc13‐4 protein.MethodsFor the first time, we aimed to systematically review clinical features, immunologic data, and genetic findings of patients with FHL3. We conducted electronic searches for English‐language articles in PubMed, Web of Science, EMBASE, and Scopus databases to collect comprehensive records related to patients with UNC13D mutations.ResultsA total of 279 abstracts were initially reviewed for inclusion. Among them, 57 articles corresponding to 322 individual FHL3 patients fulfilled our selection criteria. Finally, 73 and 249 patients were considered as severe and mild feature groups, respectively. Our results confirmed that fever, hepatosplenomegaly, and hemophagocytosis are common clinical features in the disease. Moreover, reduced fibrinogen and NK cell activity, as well as increased ferritin and triglycerides, are important markers for early diagnosis of the FHL3 disease. Investigation of genotype showed that the most prevalent type and zygosity of UNC13D are splice‐site errors and compound heterozygous, respectively.ConclusionFHL3 patients have a wide range of clinical manifestations, which makes it difficult to diagnose. Therefore, it seems that the sequencing of the entire UNC13D gene (coding and non‐coding regions) is the most appropriate way to accurate diagnosis of FHL3 patients.
Meta‐analysis of hematopoietic stem cell transplantation in major histocompatibility complex class II deficiency
Authors: Castano‐Jaramillo Lina Maria , Bareño‐Silva Jose , Tobon Santiago , Escobar‐Gonzalez Andres Felipe 
Published: July 2020

AbstractMajor histocompatibility complex class II deficiency is a rare case of PID. Specific recommendations for hematopoietic stem cell transplant, the only curative treatment option, are still lacking. This meta‐analysis aims to identify the factors associated with better prognosis in these patients. Thirteen articles reporting 63 patients with major histocompatibility complex class II deficiency that underwent hematopoietic stem cell transplant were included. The median age for hematopoietic stem cell transplant was 18 months. The most common source of transplant was bone marrow, with alternative sources as umbilical cord blood emerging during recent years. The highest proportion of engraftment was seen with umbilical cord. Engraftment was higher in patients with matched donors, with better overall survival in patients with reduced‐intensity conditioning. Graft‐vs‐host disease developed in 65% of the patients, with grades I‐II being the most frequently encountered. There was a higher mortality in patients with myeloablative conditioning and no engraftment. There was an inverse correlation between survival and stage of graft‐vs‐host disease. The main cause of mortality was infectious disease, mostly secondary to viral infections. Ideally, matched grafts should be used, and reduced‐intensity conditioning should be considered to reduce early post‐transplant complications. GVHD and viral prophylaxis are fundamental.
Water vapor permeation through topical films on a moisture‐releasing skin Model
Authors: Keshavarzi Fatemeh , Zajforoushan Moghaddam Saeed , Barré Pedersen Malene , Østergaard Knudsen Nina , Jafarzadeh Shadi , Thormann Esben 
Published: July 2020

AbstractBackgroundCovering the skin by topical films affects the skin hydration and transepidermal water loss (TEWL). In vivo studies to investigate the water vapor permeation through topical films are complicated, expensive, ethically not preferred, and time‐ and labor‐consuming. The objective of this study was to introduce an in vitro and subject‐independent alternative evaluation method to predict the breathability of topical formulations.MethodsIn this study, we developed an in vitro setup to simulate the TEWL values of human skin and investigated the breathability of five polymeric film formers used in topical formulations. Furthermore, a comparative in vivo TEWL study was performed on ten human volunteers with defined areas of skin covered with films of two selected polymers possessing different barrier properties.ResultsBy employing the in vitro setup, a vinylpyrrolidone/acrylates/lauryl methacrylate copolymer was determined to form the most breathable film, whereas acrylates/octylacrylamide copolymer and shellac films showed the highest barrier properties. The in vivo TEWL study demonstrated the same relative barrier properties for the acrylates/octylacrylamide and polyurethane‐64 films, despite a more complex driving force for water vapor permeation due to moisture accumulation on the covered skin surfaces.ConclusionWe obtained a good correlation between the in vitro and in vivo results, demonstrating that our model can categorize different polymeric film formers based on their breathability when applied to human skin. This information can aid in selecting suitable film‐forming polymers for topical formulations with either breathable or occluding functionalities.
Accuracy of diagnostic tests for American tegumentary leishmaniasis: a systematic literature review with meta‐analyses
Authors: Pena Heber Paulino , Belo Vinícius Silva , Xavier‐Junior José Cândido Caldeira , Teixeira‐Neto Rafael Gonçalves , Melo Saulo Nascimento , Pereira Diego Andrade , Fontes Igor de Campos , Santos Ingrid Morselli , Lopes Valeriana Valadares , Tafuri Wagner Luiz , Romero Gustavo Adolfo Sierra , da Silva Eduardo Sérgio 
Published: July 2020

AbstractObjectivesTo analyse the accuracy of American tegumentary leishmaniasis (ATL) diagnostic methods and evaluate the quality of the existing publications by means of a systematic review.MethodsDiagnostic tests evaluated in at least two studies with common reference standards were included in the sensitivity and/or specificity meta‐analyses. Quality and susceptibility to bias were analysed using the QUADAS‐2 and STARD tools.ResultsThe title and abstract of 3387 publications were evaluated after deduplication resulting from database searches. Thirty‐eight studies were included in the review, and 26 of them had results inserted in meta‐analyses. The diagnostic methods with the highest pooled sensitivity values were ELISA, polymerase chain reaction (PCR), indirect immunofluorescence reaction and Montenegro’s intradermal reaction. Cytometry was assessed in only two studies and presented 100% sensitivity in both. Smear slide microscopy and histopathology showed low pooled values of sensitivity. For specificity, the highest pooled values were identified for PCR. High values were also identified for ELISA, except for studies in which the reference standard for defining negative participants included individuals with Chagas’ disease or paracoccidioidomycosis, which also occurred for cytometry. IFR had lower specificities than ELISA. There was a predominance of case–control designs of phase 1 or 2 and only four studies were strongly recommended as evidence generators. Several reference standards were adopted, and different methods were assessed in a small number of studies.ConclusionPCR showed the highest accuracy for the diagnosis of ATL, and its use should be encouraged in clinical practice. ELISA is recommended for the screening of suspected individuals, but the possibility of cross‐reactions should be considered. New validation studies for the tests evaluated in few publications and studies of phase 3 with appropriate methods are needed.
Chapter 1: Introduction to Social Media for Professional Development and Learning in Physical Education and Sport Pedagogy
Authors: Harvey Stephen , Carpenter Jeffrey P. , Hyndman Brendon P. 
Published: July 2020

Social media sites (e.g., Facebook, Twitter, Voxer, Instagram, etc.) have become platforms for self-directed professional development and learning (PDL) for many educators, including physical educators and sports coaches. The aim of this chapter is to provide an introduction to this current monograph on physical educators’ and sports coaches’ social media use for PDL by presenting key issues and relevant literature, and previewing the chapters to follow. The chapter begins with a background discussion of social media, followed by brief literature reviews of PDL research in education and physical education and sport pedagogy, and research on social media use for PDL. Next, an overview of key theories and concepts used within the monograph is provided. The chapter concludes with individual summaries of the six empirical chapters of the monograph.
Acute promyelocytic leukaemia long-term survivors: higher fatigue and greater overall symptom burden
Authors: Sommer Kathrin , Vignetti Marco , Cottone Francesco , Breccia Massimo , Annibali Ombretta , Luppi Mario , Intermesoli Tamara , Borlenghi Erika , Carluccio Paola , Rodeghiero Francesco , Fabbiano Francesco , Romani Claudio , Sborgia Marco , Martino Bruno , Crugnola Monica , Efficace Fabio 
Published: July 2020

ObjectiveWe aimed to investigate the association of fatigue with severity of other key cancer symptoms, as well as symptom interference with daily activities and outlook on life, in long-term survivors of acute promyelocytic leukaemia (APL).MethodsThe study sample consisted of APL survivors (n=244), with a median time from diagnosis of 14.3 years (IQR=11.1–16.9 years), previously enrolled in a long-term follow-up study. Symptom severity and symptom interference were assessed using the well-validated MD Anderson Symptom Inventory (MDASI). Fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire.ResultsHigher fatigue burden was associated with increased affective symptoms, memory problems, drowsiness, sleep disturbances, shortness of breath and pain. Higher levels of fatigue were also associated with higher scores across all interference items of the MDASI. Overall, symptoms interfered most with mood, but among APL survivors with high levels of fatigue, symptoms interfered most with enjoyment of life. Multivariable regression analysis confirmed the independent association between fatigue and all symptom severity items of the MDASI.ConclusionsThe current findings show that long-term APL survivors who report higher fatigue also experience a greater overall symptom burden and a substantial impact on performance of daily activities. Further studies are needed to examine whether interventions aimed at reducing fatigue could also reduce overall symptom burden.
Family meetings in paediatric palliative care: an integrative review
Authors: Bradford Natalie , Rolfe Melanie , Ekberg Stuart , Mitchell Geoffrey , Beane Theresa , Ferranti Kahli , Herbert Anthony 
Published: July 2020

ObjectiveOur aim was to synthesise the available evidence surrounding the structure, processes and outcomes of family meetings in the paediatric palliative care literature.MethodsWe undertook an integrative literature review informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The protocol was registered with PROSPERO (CRD42019138938). Electronic databases were systematically search using keywords and hand searching of reference articles and grey literature was also completed.ResultsTen empirical studies and five theoretical articles were included in the synthesis. Empirical studies provided more information about meeting structure, whereas theoretical articles more frequently described a desired process for planning and undertaking meetings. No articles identified how the success of a meeting was defined or made recommendations for doing so. Despite reports that family meetings are commonly occurring, few articles described outcomes from either the family or clinician perspectives.ConclusionsFamily meetings are essential communication strategies commonly used in paediatric palliative care, yet there is little guidance about how meetings should be organised and conducted, who should participate and when they should occur. The limited data available on the outcomes of family meetings suggest improvements are required to meet the needs of families. We present a framework that synthesises the available evidence. The framework offers an overview of the elements to consider when planning for and undertaking family meetings in paediatric palliative care and may be useful for both clinicians and researchers.
Comparison of the characteristics of work-related injuries between older workers and the workers of the conventional working-age in the Republic of Korea, 2010–2014
Authors: Lee Kyung-Eun , Kim Jinhee , Lee Jihye 
Published: July 2020

ObjectiveWith population ageing, the number of older workers is increasing and the number of work-related injuries in older people is also increasing. Occupational patterns and work-related injury patterns vary with age. This study aimed to compare the incidence and characteristics of work-related injuries in older and younger workers in Korea.MethodsWe conducted a retrospective review of the characteristics of workers hospitalised with work-related injuries from January 2010 to December 2014, using data from the National Hospital Discharge In-Depth Injury Survey in South Korea. The analysis was stratified by age into older (aged ≥65 years) and younger (aged 20–64 years) workers.ResultsThe hospitalisation rate in older workers was double that of younger workers (2014 IRR: 2.06, 95% CI 1.53 to 2.76). Compared with workers of conventional working-age, a higher proportion of injured older workers were female (33.1% vs 13.6%, p<0.001), injured due to falls (40.8% vs 28.5%) and injured while working on a farm (46.5% vs 6.3%, p<0.001). In older workers, work-related injuries were seasonal and peaked during summer, but there was little seasonality in injuries among younger workers.ConclusionOlder workers are more vulnerable to work-related injuries and have a different profile of work-related injuries from younger workers. Age-related differences in the injury profile need to be considered when developing workplace injury prevention policies and programmes, and the specific vulnerabilities of older workers need to be addressed.