bluuebunny/crossref_metadata_2025_split huggingface dataset:
National variations in perioperative assessment and surgical management of Crohn’s disease: a multicentre study
Authors:   SICCR Current Status of Crohn’s Disease Surgery Collaborative
Published: September 2020

AbstractAimCrohn's disease (CD) requires a multidisciplinary approach and surgery should be undertaken by dedicated colorectal surgeons with audited outcomes. We present a national, multicentre study, with the aim to collect benchmark data on key performance indicators in CD surgery, to highlight areas where standards of CD surgery excel and to facilitate targeted quality improvement where indicated.MethodsAll patients undergoing ileocaecal or redo ileocolic resection in the participating centres for primary and recurrent CD from June 2018 to May 2019 were included. The main objective was to collect national data on hospital volume and practice variations. Postoperative morbidity was the primary outcome. Laparoscopic surgery and stoma rate were the secondary outcomes.ResultsIn all, 715 patients were included: 457 primary CD and 258 recurrent CD with a postoperative morbidity of 21.6% and 34.7%, respectively. Laparoscopy was used in 83.8% of primary CD compared to 31% of recurrent CD. Twenty‐five hospitals participated and the total number of patients per hospital ranged from 2 to 169. Hospitals performing more than 10 primary CD procedures per year showed a higher adoption of laparoscopy and bowel sparing surgery.ConclusionsThere is significant heterogeneity in the number of CD surgeries performed per year nationally in Italy. Our data suggest that high‐volume hospitals perform more complex procedures, with a higher adoption of bowel sparing surgery. The rate of laparoscopy in high‐volume hospitals is higher for primary CD but not for recurrent CD compared with low‐volume hospitals.
Adding Types, But Not Tokens, Affects Property Induction
Authors: Xie Belinda , Navarro Danielle J. , Hayes Brett K. 
Published: September 2020

AbstractThe extent to which we generalize a novel property from a sample of familiar instances to novel instances depends on the sample composition. Previous property induction experiments have only used samples consisting of novel types (unique entities). Because real‐world evidence samples often contain redundant tokens (repetitions of the same entity), we studied the effects on property induction of adding types and tokens to an observed sample. In Experiments 1–3, we presented participants with a sample of birds or flowers known to have a novel property and probed whether this property generalized to novel items varying in similarity to the initial sample. Increasing the number of novel types (e.g., new birds with the target property) in a sample produced tightening, promoting property generalization to highly similar stimuli but decreasing generalization to less similar stimuli. On the other hand, increasing the number of tokens (e.g., repeated presentations of the same bird with the target property) had little effect on generalization. Experiment 4 showed that repeated tokens are encoded and can benefit recognition, but appear to be given little weight when inferring property generalization. We modified an existing Bayesian model of induction (Navarro, Dry, & Lee, 2012) to account for both the information added by new types and the discounting of information conveyed by tokens.
Heart transplantation in patients with localized prostate cancer—Are we denying a life‐saving therapy due to an indolent tumor?
Authors: Raikhelkar Jayant , Pham Michael , Lourenco Laura , Narang Nikhil , Chung Ben , Nguyen Ann , Kim Gene , Sayer Gabriel , Uriel Nir 
Published: September 2020

AbstractBackgroundProstate cancer (PC) is the most common non‐cutaneous cancer in men. Approximately 90% of these cancers are localized (LPC) with a cancer‐specific survival rate of 99% at 10 years. Some heart transplant centers (HTCs) regard PC as an absolute contraindication to heart transplantation (HT). This study aims to understand the current status of HT in patients with advanced heart failure (AHF) and concurrent LPC in the United States.MethodsAdult HTCs in the United States were asked to fill out an email questionnaire addressing their current approach to HT in AHF patients with concurrent LPC.ResultsFifty of the 90 HTCs that received the questionnaire responded. Only 16% of HTCs had a formal policy regarding HT in patients with LPC, while only 10% had patients with LPC on the HT waitlist at the time of the survey. Overall, 84% of the HTCs had never performed HT in a patient with LPC in the history of their transplant program.ConclusionAn overwhelming majority of HTCs in the United States do not consider HT an option for AHF patients with concurrent LPC and lack a formal policy regarding the same.
The International Association of Dental Traumatology ToothSOS mobile app: A 2‐year report
Authors: Khehra Anahat , Cohenca Nestor , Cehreli Zafer C. , Levin Liran 
Published: September 2020

AbstractBackground/AimThe shift in health care and technology calls for innovation through mobile applications as free educational resources for the masses. The International Association of Dental Traumatology (IADT) created ToothSOS, an app (software application for mobile devices) to provide dental trauma information for patients and professionals. The app contains information on the emergency management and prevention of dental injuries, as well as treatment guidelines for dental practitioners. The aim of this study was to assess public utilization of the ToothSOS app in the first 2 years since its launch.MethodsThe ToothSOS app was launched by the IADT in the first week of April 2018. Data regarding the number of downloads and usage of the app in the first 2 years (from April 2018 to May 2020) were collected and analyzed.ResultsThe total number of ToothSOS downloads over the 2 years was 47 725. The number of downloads peaked in the first month when the app was initially released. Thereafter, the number of downloads decreased to an average of 1423 ± 363 downloads every month. Europe was the territory with the greatest number of downloads followed by the United States and Canada, Asia, Latin America and the Caribbean, and Africa, the Middle East, and India.ConclusionsWithin as short a period as 2 years, the ToothSOS app continues to gain public interest. Further attempts and public campaigns should be made in order to increase the visibility of the app. Dental professionals should encourage patients and communities to use the app in order to increase awareness for the prevention and proper emergency management of traumatic dental injuries.
Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus
Authors: Bauer Tobias , David Bastian , Ernst Leon , Becker Albert J. , Witt Juri‐Alexander , Helmstaedter Christoph , Wagner Jan , Weber Bernd , Elger Christian E. , Surges Rainer , Rüber Theodor 
Published: September 2020

AbstractLimbic encephalitis (LE) forms a spectrum of autoimmune diseases involving temporal lobe epilepsy and memory impairment. Imaging features of LE are known to depend on the associated antibody and to occur on the brain network level. However, first studies investigating brain networks in LE have either focused on one distinct antibody subgroup or on distinct anatomical regions. In this study, brain graphs of 17 LE patients with autoantibodies against glutamic acid decarboxylase 65 (GAD‐LE), four LE patients with autoantibodies against leucine‐rich glioma‐inactivated 1, five LE patients with autoantibodies against contactin‐associated protein‐like 2, 26 age‐ and gender‐matched healthy control subjects, and 20 epilepsy control patients with hippocampal sclerosis were constructed based on T1‐weighted structural magnetic resonance imaging scans and diffusion tensor imaging. GAD‐LE showed significantly altered global network topology in terms of integration and segregation as compared to healthy controls and patients with hippocampal sclerosis (P < .01, analysis of variance with Tukey‐Kramer post hoc tests). Linear regression linked global network measures with amygdala volume and verbal memory performance (P < .05). Alterations of local network topology show serotype dependence in hippocampus, amygdala, insula, and various cortical regions. Our findings reveal serotype‐dependent patterns of structural connectivity and prove the relevance of in silico network measures on clinical grounds.
Comparative genomics highlights the importance of drug efflux transporters during evolution of mycoparasitism in Clonostachys subgenus Bionectria (Fungi, Ascomycota, Hypocreales)
Authors: Broberg Martin , Dubey Mukesh , Iqbal Mudassir , Gudmundssson Mikael , Ihrmark Katarina , Schroers Hans‐Josef , Funck Jensen Dan , Brandström Durling Mikael , Karlsson Magnus 
Published: September 2020

AbstractVarious strains of the mycoparasitic fungal species Clonostachys rosea are used commercially as biological control agents for the control of fungal plant diseases in agricultural crop production. Further improvements of the use and efficacy of C. rosea in biocontrol require a mechanistic understanding of the factors that determines the outcome of the interaction between C. rosea and plant pathogenic fungi. Here, we determined the genome sequences of 11 Clonostachys strains, representing five species in Clonostachys subgenus Bionectria, and performed a comparative genomic analysis with the aim to identify gene families evolving under selection for gene gains or losses. Several gene families predicted to encode proteins involved in biosynthesis of secondary metabolites, including polyketide synthases, nonribosomal peptide syntethases and cytochrome P450s, evolved under selection for gene gains (p ≤ .05) in the Bionectria subgenus lineage. This was accompanied with gene copy number increases (p ≤ .05) in ATP‐binding cassette (ABC) transporters and major facilitator superfamily (MFS) transporters predicted to contribute to drug efflux. Most Clonostachys species were also characterized by high numbers of auxiliary activity (AA) family 9 lytic polysaccharide monooxygenases, AA3 glucose–methanol–choline oxidoreductases and additional carbohydrate‐active enzyme gene families with putative activity (or binding) towards xylan and rhamnose/pectin substrates. Particular features of the C. rosea genome included expansions (p ≤ .05) of the ABC‐B4 multidrug resistance transporters, the ABC‐C5 multidrug resistance‐related transporters and the 2.A.1.3 drug:H + antiporter‐2 MFS drug resistance transporters. The ABC‐G1 pleiotropic drug resistance transporter gene abcG6 in C. rosea was induced (p ≤ .009) by exposure to the antifungal Fusarium mycotoxin zearalenone (1121‐fold) and various fungicides. Deletion of abcG6 resulted in mutants with reduced (p < .001) growth rates on media containing the fungicides boscalid, fenhexamid and iprodione. Our results emphasize the role of biosynthesis of, and protection against, secondary metabolites in Clonostachys subgenus Bionectria.
Long‐term effects of 7‐year warming experiment in the field on leaf hydraulic and economic traits of subtropical tree species
Authors: Wu Ting , Tissue David T. , Li Xu , Liu Shizhong , Chu Guowei , Zhou Guoyi , Li Yuelin , Zheng Mianhai , Meng Ze , Liu Juxiu 
Published: September 2020

AbstractRising temperature associated with climate change may have substantial impacts on forest tree functions. We conducted a 7‐year warming experiment in subtropical China by translocating important native forest tree species (Machilas breviflora, Syzygium rehderianum, Schima superba and Itea chinensis) from cooler high‐elevation sites (600 m) to 1–2°C warmer low‐elevation sites (300 and 30 m) to investigate warming effects on leaf hydraulic and economic traits. Here, we report data from the last 3 years (Years 5–7) of the experiment. Warming increased leaf hydraulic conductance of S. superba to meet the higher evaporative demand. M. breviflora (300 m), S. rehderianum, S. superba and I. chinensis (300 and 30 m) exhibited higher area‐based and mass‐based maximum photosynthetic rates (Aa and Am, respectively) related to increasing stomatal conductance (gs) and stomatal density in the wet season, which led to rapid growth; however, we observed decreased growth of M. breviflora at 30 m due to lower stomatal density and decreased Aa in the wet season. Warming increased photosynthetic nitrogen‐use efficiency and photosynthetic phosphorus‐use efficiency, but reduced leaf dry mass per unit area due to lower leaf thickness, suggesting that these tree species allocated more resources into upregulating photosynthesis rather than into structural investment. Our findings highlight that there was trait variation in the capacity of trees to acclimate to warmer temperatures such that I. chinensis may benefit from warming, but S. superba may be negatively influenced by warming in future climates.
What COVID‐19 could mean for the future of “work from home”: The provocations of three women in the academy
Authors: Couch Danielle L. , O'Sullivan Belinda , Malatzky Christina 
Published: September 2020

AbstractThe COVID‐19 pandemic saw academic labor rapidly shift into domestic spaces at the same time as households were “locked down.” In this article, we offer an exploration of our own experiences of working from home as women and mothers in the academy. Inspired by feminist approaches to knowledge production and self‐reflection, we each developed a personal reflective narrative guided by three key questions centered on our experiences of working from home pre‐ and during the COVID‐19 pandemic, and what this may mean for the future of our work. We then collectively analyzed how our personal stories reflected different dimensions of the experience of working from home, and our fears and hopes for the future. We present three distilled themes from our collective experiences here with the aim of entering a dialog with others seeking to live feminist lives during this time, and beyond.
Review ‐ Helicobacter pylori and non‐malignant upper gastro‐intestinal diseases
Authors: Schulz Christian , Kupčinskas Juozas 
Published: September 2020

AbstractThis review takes into account recent publications focusing on the relationship between Helicobacter pylori infection and non‐malignant diseases of the upper gastro‐intestinal tract. The authors have summarized current knowledge on associations between the H pylori infection and non‐malignant upper GI conditions including gastroesophageal reflux disease (GERD), Barrett's esophagus, eosinophilic esophagitis (EOE), peptic ulcer disease (PUD), H pylori gastritis, celiac disease and functional dyspepsia. In the field of GERD, current data focusing on different locations of H pylori infection detect significant differences between antrum‐ and corpus predominant gastritis explainable by different changes in acid secretion in different gastric niches. High volume studies from Sweden and Brazil underline the safety of H pylori eradication concerning the risk of Barret's esophagus or adenocarcinoma. The relationship betweenH pylori infection and EOE remains uncertain, but current data supports the concept of expected positive and protective effects of H pylori exposure reducing the risk of EOE. Analyzing biomarkers might be helpful to identify subjects under risk for the development of precancerous lesions after H pylori infection, where microRNAs, IL‐9 and IL‐4, and also Tc17/9 and Th17/9 and microbiota profiles showed promising results to identify subgroups under risk.
Papillary‐cystic neoplasms of the middle ear are distinct from endolymphatic sac tumours
Authors: Taverna Cecilia , Pollastri Federica , Pecci Rudi , Giannoni Beatrice , Fattorini Caterina , Santucci Marco , Mueller Sarina K , Stoehr Robert , Franchi Alessandro , Agaimy Abbas 
Published: September 2020

AimsPapillary neoplasms of the middle and inner ear are rare and poorly characterised. The current World Health Organization classification divides them into two major subtypes: aggressive papillary tumours (APTs) and endolymphatic sac tumours (ELSTs). The aim of this article is to present two papillary neoplasms of the middle ear that do not fit into either the classic APT category or the classic ELST category, and compare them with three ELSTs.Methods and resultsThe patients were a 48‐year‐old female and a 59‐year‐old male without a history of other neoplasms. Histology showed papillary‐cystic growth of predominantly oncocytic (Case 1) or mucinous (Case 2) cells surrounded by a p63‐positive basal layer. The overall histology was reminiscent of oncocytic sinonasal papilloma (Case 1) and pancreatobiliary or salivary intraductal papillary mucinous neoplasms (Case 2). Ovarian‐type stroma, invasion and malignant features were absent. Immunohistochemistry revealed expression of cytokeratin (CK) 7, but not carbonic anhydrase IX (CAIX) or paired box gene 8 (PAX8) (except for very focal PAX8 expression in Case 1). The TST15 gene panel and HRAS sequencing revealed no pathogenic mutations in BRAF, KRAS, EGFR, AKT1, or HRAS. The TruSight RNA fusion panel revealed an MKRN1–BRAF fusion in Case 1. No fusion was detected in Case 2. The three ELSTs showed classic features of the entity, expressed CK7, epithelial membrane antigen, PAX8, and CAIX, and lacked a basal cell layer.ConclusionThese novel cases suggest that papillary tumours of the ear represent a heterogeneous spectrum of distinct neoplasms unified by a prominent papillary‐cystic pattern rather than a single entity. Future studies should clarify whether the MKRN1–BRAF fusion is a defining recurrent driver event, especially in those cases reported as sinonasal‐type middle ear papillomas.
Ferroelectric and photocatalytic properties of Aurivillius phase Ca2Bi4Ti5O18
Authors: Wang Yaqiong , Zhang Man , Wu Jiyue , Hu Zimeng , Zhang Hongtao , Yan Haixue 
Published: September 2020

AbstractAurivillius phase Ca2Bi4Ti5O18 powders with micrometer size were produced by solid‐state reaction. X‐ray diffraction revealed that the powders had polar orthorhombic structure with space group of B2cb. Ca2Bi4Ti5O18 ceramic exhibited frequency independent dielectric anomaly at 774°C. The piezoelectric coefficient d33 value of poled Ca2Bi4Ti5O18 pellets was 0.7 ± 0.2 pC/N. Both frequency independent dielectric anomaly and detectable d33 value clearly indicated that Ca2Bi4Ti5O18 is a ferroelectric material with Curie point of 774 ℃. UV–vis absorption spectra revealed that Ca2Bi4Ti5O18 had a direct band gap of 3.2 eV. Photocatalytic activity of the Ca2Bi4Ti5O18 powders was examined by degradation of rhodamine B (RhB) under simulated solar light. 16% of RhB solution was degraded by Ca2Bi4Ti5O18 powders after 4 hours UV‐vis irradiation. With Ag nanoparticles deposited on the Ca2Bi4Ti5O18 powders surface, 50% of RhB was degraded under the same irradiation condition. The fitted degradation rate constant of Ag decorated Ca2Bi4Ti5O18 was 4 times higher than that of bare Ca2Bi4Ti5O18. This work suggested that the Aurivillius ferroelectric Ca2Bi4Ti5O18 is a promising candidate for photocatalytic applications.
Effect of rs4719839 polymorphism on risk of ventilator‐associated pneumonia, expression of microRNA‐148 and autophagy‐related 16‐like 1 (ATG16L1)
Authors: Wang Shu‐peng , Li Wen , Li Chen , Duan Xue‐yan , Duan Jun 
Published: September 2020

AbstractMiR‐148 is a negative regulator of autophagy 16‐like 1 (ATG16L1), a gene implicated in the pathogenesis of ventilator‐associated pneumonia (VAP). Therefore, the role of miR‐148 polymorphism in the pathogenesis of VAP was studied here. The expression of miR‐148, ATG16L1, Beclin‐I, LC3‐II, TNF‐α and IL‐6 in serum and peripheral blood mononuclear cells (PBMCs) of VAP patients was detected to study their relationship in the pathogenesis of VAP. Chronic obstructive pulmonary disease patients carrying the AA/AG genotypes of miR‐148 rs4719839 single nucleotide polymorphism (SNP) were more prone to VAP due to the higher expression of miR‐148, TNF‐α and IL‐6 along with suppressed expression of ATG16L1, Beclin‐I and LC3‐II in their serum and PBMCs. Transfection of miR‐148 mimics to primary PBMCs genotyped as GG and AA decreased the expression of ATG16L1, Beclin‐I and LC3‐II. Finally, cells carrying the AA genotype of rs4719839 SNP were more sensitive to the role of LPS stimulation in suppressing ATG16L1, Beclin‐I and LC3‐II expression while activating TNF‐α and IL‐6 expression. Our work presented detailed evidence, suggesting that the rs4719839 polymorphism can affect the risk of VAP.
Down‐regulation of diesel particulate matter‐induced airway inflammation by the PDZ motif peptide of ZO‐1
Authors: Kang Dong Hee , Lee Tae‐Jin , Kim Ji Wook , Shin Yu Som , Kim Ju Deok , Ryu Sung Won , Ryu Siejeong , Choi Yung Hyun , Kim Cheol Hong , You EunAe , Rhee SangMyung , Song Kyoung Seob 
Published: September 2020

AbstractAlthough diesel airborne particulate matter (PM2.5) has been known to play a role in many human diseases, there is no direct evidence that therapeutic drugs or proteins can diminish PM2.5‐induced diseases. Nevertheless, studies examining the negative control mechanisms of PM2.5‐induced diseases are critical to develop novel therapeutic medications. In this study, the consensus PDZ peptide of ZO‐1 inhibited PM2.5‐induced inflammatory cell infiltration, pro‐inflammatory cytokine gene expression, and TEER in bronchoalveolar lavage (BAL) fluid and AM cells. Our data indicated that the PDZ domain in ZO‐1 is critical for regulation of the PM2.5‐induced inflammatory microenvironment. Therefore, the PDZ peptide may be a potential therapeutic candidate during PM‐induced respiratory diseases.
The role of dental insurance in mitigating mortality among working‐age U.S. adults with periodontitis
Authors: Sadiq Naveed , Probst Janice C. , Merchant Anwar T. , Martin Amy B. , Shrestha Deepika , Khan M. Mahmud 
Published: September 2020

AbstractAimTo assess the relationship of dental insurance with all‐cause mortality and mortality due to cardiovascular diseases (CVD), diabetes mellitus (DM), and cerebrovascular diseases (CBD) among those with periodontitis.Materials and MethodsNHANES III and its associated mortality data set were used in this study. The outcome variables were “all‐cause mortality” and “combined mortality” due to CVD, DM, and CBD. The independent variable was dental insurance stratified over periodontitis status. Unweighted frequencies with weighted column percentages were used for descriptive statistics, and chi‐square test was applied for significance. Cox proportional hazard models were used for stratified multivariable analyses. All analyses were performed in SAS v9.4 accounting for survey data complexities. Significance level was kept at 5%.ResultsThe mortality was 14.58% for all‐cause mortality and 4.06% for combined mortality among those with periodontitis in this study. Dental insurance significantly reduced the hazard of all‐cause mortality among those with periodontitis (HR: 0.75; 95% CI: 0.61 – 0.93), adjusted for covariates. However, no association of dental insurance with combined mortality was observed among periodontitis group.ConclusionsDental insurance reduces hazard of all‐cause mortality among those with periodontitis. Dental insurance ensures access to dentists and improves oral and dental health. Longitudinal study is needed to establish causality.