bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension
Authors: Burmester Gerd R , Strand Vibeke , Rubbert-Roth Andrea , Amital Howard , Raskina Tatiana , Gómez-Centeno Antonio , Pena-Rossi Claudia , Gervitz Leon , Thangavelu Karthinathan , St John Gregory , Boklage Susan , Genovese Mark C 
Published: October 2019

ObjectiveEvaluate open-label sarilumab monotherapy in patients with rheumatoid arthritis switching from adalimumab monotherapy in MONARCH (NCT02332590); assess long-term safety and efficacy in patients continuing sarilumab during open-label extension (OLE).MethodsDuring the 48-week OLE, patients received sarilumab 200 mg subcutaneously once every 2 weeks. Safety (March 2017 cut-off) and efficacy, including patient-reported outcomes, were evaluated.ResultsIn the double-blind phase, patients receiving sarilumab or adalimumab monotherapy showed meaningful improvements in disease activity; sarilumab was superior to adalimumab for improving signs, symptoms and physical function. Overall, 320/369 patients completing the 24-week double-blind phase entered OLE (155 switched from adalimumab; 165 continued sarilumab). Sarilumab safety profile was consistent with previous reports. Treatment-emergent adverse events were similar between groups; no unexpected safety signals emerged in the first 10 weeks postswitch. Among switch patients, improvement in disease activity was evident at OLE week 12: 47.1%/34.8% had changes ≥1.2 in Disease Activity Score (28 joints) (DAS28)-erythrocyte sedimentation rate/DAS28-C-reactive protein. In switch patients achieving low disease activity (LDA: Clinical Disease Activity Index (CDAI) ≤10; Simplified Disease Activity Index (SDAI) ≤11) by OLE week 24, 70.7%/69.5% sustained CDAI/SDAI LDA at both OLE weeks 36 and 48. Proportions of switch patients achieving CDAI ≤2.8 and SDAI ≤3.3 by OLE week 24 increased through OLE week 48. Improvements postswitch approached continuation-group values, including scores ≥normative values.ConclusionsDuring this OLE, there were no unexpected safety issues in patients switching from adalimumab to sarilumab monotherapy, and disease activity improved in many patients. Patients continuing sarilumab reported safety consistent with prolonged use and had sustained benefit.
A randomised controlled trial investigating the effects of administering a non‐steroidal anti‐inflammatory drug to beef calves assisted at birth and risk factors associated with passive immunity, health, and growth
Authors: Pearson Jennifer M , Pajor Edward , Campbell John , Levy Michel , Caulkett Nigel , Windeyer M Claire 
Published: October 2019

BackgroundThe objectives of this study were to investigate the impact of pain mitigation at birth to assisted beef calves and determine the risk factors associated with transfer of passive immunity (TPI), health, and growth.MethodsTwo hundred and thirty cow–calf pairs requiring calving assistance were enrolled. Calves were randomised to receive meloxicam (0.5 mg/kg) or an equivalent volume of placebo subcutaneously at birth. Calf blood samples were collected between one and seven days of age to determine serum immunoglobulin (IgG) concentration. Colostrum intake, treatment for disease, mortality, and weaning weights were recorded. Multilevel linear or logistic regression models were used to determine the effects of meloxicam and to identify risk factors.ResultsThere was no effect of meloxicam on serum IgG concentrations, average daily gain (ADG), or risk of inadequate TPI (serum IgG concentration <24 g/l), treatment for disease, or mortality (P>0.05). Bottle or tube feeding calves were associated with decreased serum IgG concentrations (P=0.01) compared with nursing. Calves with an incomplete tongue withdrawal reflex had higher odds of being treated for disease compared with those with complete withdrawal (P=0.009). Being born meconium‐stained and having decreased serum IgG concentrations were associated with an increased risk of mortality (P=0.03). Being born of a mature cow, having a higher birth weight, and increased serum IgG concentrations were associated with greater ADG to weaning (P<0.05).ConclusionVigour assessment at birth along with good colostrum management may be important to improve TPI and health in high‐risk calves such as those assisted at birth.
Challenging identity: development of a measure of veterinary career motivations
Authors: Cake Martin , McArthur Michelle L , Mansfield Caroline F , Zaki Sanaa , Carbonneau Kira , Matthew Susan M 
Published: October 2019

BackgroundWhile little is known about the motivations underpinning veterinary work, previous literature has suggested that the main influences on veterinary career choice are early/formative exposure to animals or veterinary role models. The aim of this study was to develop and provisionally validate a veterinary career motivations questionnaire to assess the strength of various types of career motivations in graduating and experienced veterinarians.MethodsA cross‐sectional sample of experienced veterinarians (n=305) and a smaller cohort of newly graduated veterinarians (n=53) were surveyed online using a long‐form questionnaire. Exploratory factor analysis (EFA) was used to iteratively derive a final, short‐form questionnaire for survey of a second cross‐sectional sample of experienced veterinarians (n=751).ResultsEFA derived a final questionnaire with 22 items loading onto six factors (social purpose, animal orientation, vocational identity, challenge and learning, career affordances, and people orientation). While motivations based on animal orientation were predictably strong, those based on vocational identity were not universal and were weaker in younger and graduate veterinarians; both of these motivations were rated lower by male veterinarians. Motivations based on challenge and learning emerged as some of the strongest, most universal and most influential; people orientation and social purpose were also important, particularly for older veterinarians.ConclusionThe major motivations for pursuing a veterinary career may best be represented as an intrinsic passion for animal care and for learning through solving varied challenges. These motivations are largely intrinsically oriented and autonomously regulated, thus likely to be supportive of work satisfaction and wellbeing.
Virtual Compton scattering measurements in the nucleon resonance region
Authors: Blomberg A. , Atac H. , Sparveris N. , Paolone M. , Achenbach P. , Benali M. , Beričič J. , Böhm R. , Correa L. , Distler M. O. , Esser A. , Flay D. , Fonvieille H. , Friščić I. , Kohl Y. , Merkel H. , Müller U. , Meziani Z. E. , Mihovilovic M. , Pochodzalla J. , Polychronopoulou A. , Pasquini B. , Schoth M. , Schulz F. , Schlimme S. , Sfienti C. , Sirca S. , Weber A. 
Published: October 2019

Abstract.
We report on new measurements of the electric Generalized Polarizability (GP) of the proton $ \alpha_{E}$αE in a kinematic region where a puzzling dependence on momentum transfer has been observed, and we have found that $ \alpha_E = (5.3 \pm 0.6_{stat} \pm 1.3_{sys}) 10^{-4}$αE=(5.3±0.6stat±1.3sys)10-4 fm3 at $ Q^{2}=0.20$Q2=0.20 (GeV/c)2. The new measurements, when considered along with the rest of the world data, suggest that $ \alpha_E$αE can be described by either a local plateau or by an enhancement in the region $ Q^2=0.20$Q2=0.20 (GeV/c)2 to 0.33 (GeV/c)2. The experiment also provides the first measurement of the Coulomb quadrupole amplitude in the $ N \rightarrow \Delta$N→Δ transition through the exploration of the $ p(e,e'p)\gamma$p(e,ep)γ reaction. The new measurement gives $ CMR = (-4.4 \pm 0.8_{stat} \pm 0.6_{sys})\%$CMR=(-4.4±0.8stat±0.6sys)% at $ Q^2=0.20$Q2=0.20 (GeV/c)2 and is consistent with the results from the pion electroproduction world data. It has been obtained using a completely different extraction method, and therefore represents a strong validation test of the world data model uncertainties.
Di-jet/$$\mathbf {e}^{+}\mathbf {e}^{-}+\hbox {MET}$$ to probe $$Z_2$$-odd mediators to the dark sector
Authors: Goertz Florian , Tame-Narvaez Karla , Tenorth Valentin Titus 
Published: October 2019

AbstractWe explore a scenario where dark matter (DM) couples to the Standard Model mainly via a scalar mediator$$\mathcal{S}$$Sthat is odd under a$$Z_2$$Z2symmetry, leading to interesting collider signatures. In fact, iflinear interactionswith the mediator are absent the most important DM production mechanisms at colliders could lead to final states with missing transverse energy (MET) in association with at least two fermions, such as di-jet or di-electron signatures. The framework we consider is model-independent, in a sense that it is only based on symmetry and formulated in the (extended) DM effective field theory (eDMeft) approach. Moreover, it allows to address the smallness of first-generation fermion masses via suppressed$$Z_2$$Z2breaking effects. From a di-jet + MET analysis at the LHC, we find rather loose bounds on the effective$$\mathcal{S}$$S-$$\mathcal{S}$$S-DM-DM interactions, unless the mediator couples very strongly to SM fermions, while a future$$e^+ e^-$$e+e-collider, such as CLIC, could deliver tighter constraints on the corresponding model parameters, given the mediator is leptophilic. We finally highlight the parameter space that allows to produce the observed DM density, including constraints from direct-detection experiments.
Gauge field and brane-localized kinetic terms on the chiral square
Authors: Landim Ricardo G. 
Published: October 2019

Abstract
Extra dimensions have been used as attempts to explain several phenomena in particle physics. In this paper we investigate the role of brane-localized kinetic terms (BLKT) on thin and thick branes with two flat extra dimensions (ED) compactified on the chiral square, and an abelian gauge field in the bulk. The results for a thin brane have resemblance with the 5-D case, leading to a tower of massive KK particles whose masses depend upon the compactification radius and the BLKT parameter. On the other hand, for the thick brane scenario, there is no solution that satisfy the boundary conditions. Because of this, the mechanism of suppressed couplings due to ED (Landim and Rizzo, in JHEP 06:112, 2019) cannot be extended to 6-D.
Physical mechanisms encoded in photoionization yield from IR+XUV setups
Authors: Brabec Thomas , Dinh Phuong Mai , Gao Congzhang , McDonald Chris , Reinhard Paul-Gerhard , Suraud Éric 
Published: October 2019

Abstract

We theoretically examine how and to which extent physical processes can be retrieved from two-color pump-probe experiments of atomic and molecular gases driven by an attosecond XUV pulse train and an infrared (IR) pulse. The He atom, the N2 molecule and Na clusters are investigated with time-dependent density functional theory. Results are interpreted on the basis of a simple model system. We consider observables most commonly used in experiments: ionization yield, photo-electron spectra, and angular distributions. We find that the basic time-dependent signatures are dominated by the interplay of IR laser and continuum electrons. System information, contained in the signal, will in general require careful disentangling from the effects of photon-electron dynamics.

Graphical abstract
Comments on taxonomical status of three gobiid nominal species (genus Gobius) described from Brazilian coast (Teleostei: Gobiiformes: Gobiidae)
Authors: Caires Rodrigo Antunes 
Published: October 2019

Three species described and currently included in the genus Gobius from the Brazilian coast are herein discussed. Gobius uranoscopus Sauvage is regarded as junior synonym of Bathygobius soporator based on information on holotype deposited in Muséum National d’Histoire Naturelle, Paris; G. silveiraemartinsi Ihering, known only in Rio Grande do Sul was erected based on a short description, and type material is not available, but I considered that it is junior synonym of Ctenogobius shufeldti; Gobius boekeri Ahl, 1931, described from the coast of Pará, Brazil, is a junior synonym of Gobionellus oceanicus, as both taxa are virtually identical in meristic characters and presumable morphometric differences that Ahl used to substantiate the validity of his new species actually fall into the morphometric range observed in G. oceanicus specimens and may be attributable to individual variation and to the image quality by Ahl’s original description.
Continental fishes from the Tambaba Environmentally Protected Area, Paraíba State, Brazil
Authors: Ramos Telton Pedro Anselmo , Carvalho-Rocha Yuri Gomes Ponce de , Oliveira-Silva Leonardo , Lustosa-Costa Sílvia Yasmin , Ferreira Paula Honório Pires 
Published: October 2019

Tambaba environmentally protected area is situated on the south coast of Paraíba State, within the Atlantic forest biome of the northeastern region in Brazil. The Tambaba environmentally protected area consists of a series of independent drainages: Graú, Mucatú, and Bucatú river micro-basins, and Caboclo River sub-basin that belongs to Gurugi River micro-basin. Ichthyological samples were collected in five scientific expeditions between months of June and July in 2015. Twenty-nine sites from different habitats (e.g., spanning tributaries, streams, rivers, and estuaries) were accessed for sampling. A total of 44 species distributed within 38 genera, 25 families, and 17 orders were assigned to the Tambaba hydrographic region. Freshwater species comprised 36% (n = 16) and marine-estuarine species 64% (n = 28) of the total collected specimens. Two invasive species occur in the freshwater sites: Cichla monoculus and Poecilia reticulata. Cheirodon jaguaribensis, Cichlasoma orientale, and Crenicichla brasiliensis are endemic to the Brazilian Northeast region with the first species restricted to the Northeast Caatinga and Coastal drainages hydrographic ecoregion.
Two new species and a new distributional record of Alterosa (Trichoptera: Philopotamidae) from southeastern Brazil
Authors: Novais Christina , Dumas Leandro Lourenço , Nessimian Jorge Luiz 
Published: October 2019

The genus Alterosa Blahnik (2005), with 39 extant species, is endemic to Atlantic Forest areas of southern and southeastern Brazil. Herein, we describe and illustrate two new species from Rio de Janeiro state, southeastern Brazil: Alterosa cornuta sp. nov., easily diagnosed by the horn-like intermediate appendages crossing each other, and A. araras sp. nov., recognized mainly by the extremely developed basodorsal protuberance on tergum X and by the rod-like, mesally curved preanal appendages, with at least 2 stout spine-like setae positioned at mid length and with the apex cupped. Additionally, a new distributional record for Espírito Santo state, southeastern Brazil, is provided for Alterosa falcata Blahnik (2005).
Comunicação feminista para além das margens
Authors: Cipolla Marina Martins 
Published: October 2019

Este artigo analisa a atuação do coletivo "Nós, mulheres da periferia" por meio da comunicação, com o objetivo de discutir sobre a efetividade do espaço virtual para a periferia, considerando que a internet é utilizada como um veículo integrante desse grupo de mulheres. Para isso, o texto traz um breve histórico do movimento feminista no Brasil com viés de classe e raça, analisa a periferia como determinante nesse contexto e mostra como o espaço virtual pode ajudar a fortalecer suas pautas.
Sofrimento psíquico e social na situação de desemprego
Authors: Schmidt Maria Luiza Gava , Januário Caio Augusto Rodrigues Martins , Rotoli Liliane Ubeda Morandi 
Published: October 2019

Esta pesquisa visou identificar fatores de sofrimento psíquico-social em desempregados. A coleta de dados foi realizada no Posto de Atendimento ao Trabalhador localizado num município do estado de São Paulo. Um Questionário Sociodemográfico e a escala para avaliação de sofrimento psíquico-social de trabalhadores desempregados foram utilizados para coleta de dados. Dos 100 respondentes, 57% são homens e 43% são mulheres, na faixa etária de 19 a 41 anos, com tempo médio de desemprego de 11,7 meses. A escala apresentou a média dos itens que correspondem ao sofrimento psíquico igual a 3,32 (desvio padrão = 1,29), com variação entre “às vezes” e “frequentemente” para aspectos como insegurança, medo e vergonha, enquanto a média do sofrimento social foi de 1,84 (desvio padrão = 0,98), variando entre “raramente” e “às vezes” com indicadores de suporte social de familiares e amigos. Os resultados revelaram a vivência do desemprego por parte dos respondentes e apontou para a necessidade de ações da psicologia nas áreas social, de trabalho e clínica voltadas a auxiliar nos impactos provocados pelo desemprego bem como a criação de políticas públicas para diminuir o impacto da recessão.
A Coleção Teresa Cristina do Museu Nacional do Rio de Janeiro
Authors: Ferreira Sandra 
Published: October 2019

Este artigo pretende apresentar a Coleção Teresa Cristina do Museu Nacional do Rio de Janeiro em suas possibilidades educacionais e de pesquisa, focando, em especial, nos vasos com iconografia provenientes da região da Magna Grécia. A coleção, também chamada de Coleção Mediterrânea, é composta por objetos etruscos, gregos e das colônias gregas do sul da Itália, além de importantes peças do período romano, especialmente, aquelas provenientes das cidades de Pompeia e Herculano. A intenção é, por meio de um conjunto específico de peças da coleção, realizar uma comparação com outras coleções do mundo, de modo a comprovar que a Coleção Teresa Cristina é uma coleção significativa, que pode fornecer material importante e variado para o estudo e a pesquisa.
Chest Pain Center Accreditation Is Associated With Improved In‐Hospital Outcomes of Acute Myocardial Infarction Patients in China: Findings From the CCC‐ACS Project
Authors: Fan Fangfang , Li Yuxi , Zhang Yan , Li Jianping , Liu Jing , Hao Yongchen , Smith Sidney C. , Fonarow Gregg C. , Taubert Kathryn A. , Ge Junbo , Zhao Dong , Huo Yong ,   on behalf of the CCC‐ACS Investigators
Published: October 2019

Background

Chest pain center (
CPC
) accreditation plays an important role in the management of acute myocardial infarction (
AMI
). However, no evidence shows whether the outcomes of
AMI
patients are improved with
CPC
accreditation in China.

Methods and Results

This retrospective analysis is based on a predesigned nationwide registry,
CCC
‐ACS (Improving Care for Cardiovascular Disease in China‐Acute Coronary Syndrome). The primary outcome was major adverse cardiovascular events (
MACE
), including all‐cause death, reinfarction, stent thrombosis, stroke, and heart failure. A total of 15 344
AMI
patients, from 40
CPC
‐accredited hospitals, were enrolled, including 7544 admitted before and 7800 after accreditation. In propensity score matching, 6700 patients in each group were matched. The incidence of 7‐day
MACE
(6.7% versus 8.0%;
P
=0.003) and all‐cause death (1.1% versus 1.6%;
P
=0.021) was lower after accreditation. In multivariate adjusted mixed‐effects Cox proportional hazards models,
CPC
accreditation was associated with significantly decreased risk of
MACE
(
hazard ratio:
0.78; 95%
CI,
0.68–0.91) and all‐cause death (
hazard ratio:
0.71; 95%
CI,
0.51–0.99). The risk of
MACE
and all‐cause death both followed a reverse J‐shaped trend: the risk of
MACE
and all‐cause death decreased gradually after achieving
CPC
accreditation, with minimal risk occurring in the first year, but increased in the second year and after.

Conclusions

Based on a large‐scale national registry data set,
CPC
accreditation was associated with better in‐hospital outcomes for
AMI
patients. However, the benefits seemed to attenuate over time, and reaccreditation may be essential for maintaining
AMI
care quality and outcomes.
Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study
Authors: Dayimu Alimu , Wang Chunxia , Li Jiangbing , Fan Bingbing , Ji Xiaokang , Zhang Tao , Xue Fuzhong 
Published: October 2019

Background

The association between low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides with cardiovascular disease (
CVD
) has been well studied. No previous studies considered trajectory of these lipids jointly. This study aims to characterize longitudinal trajectories of lipid profile jointly and examine its impact on incident
CVD
.

Methods and Results

A total of 9726 participants (6102 men), aged from 20 to 58 years who had lipids repeatedly measured 3 to 9 times, were included in the study. Three distinct trajectories were identified using the multivariate latent class growth mixture model: inverse U‐shape (18.72%; n=1821), progressing (66.03%; n=6422), and U‐shape (15.25%; n=1483). Compared with the U‐shape class, the adjusted hazard ratio and 95%
CI
were 1.33 (1.05–1.68) and 1.49 (1.14–1.95) for the progressing and inverse U‐shape class, respectively. The area under the curve was calculated using the integral of the model parameters. In the adjusted model, total and incremental area under the curve of lipid profile were significantly associated with
CVD
risk. Furthermore, the model‐estimated levels and linear slopes of lipids were calculated at each age point according to the latent class growth mixture model model parameters and their first derivatives, respectively. After adjusting for covariates, standardized odds ratio of slope increases gradually from 1.11 (1.02, 1.21) to 1.21 (1.12, 1.31) at 20 to 40 years and then decreased to 1.02 (0.94, 1.11) until 60 years.

Conclusions

These results indicate that the lipids profile trajectory has a significant impact on
CVD
risk. Age between 20 and 42 years is a crucial period for incident
CVD
, which has implications for early lipids intervention.
Cretan µωλεῖν ‘Contend, Bring an Action to Court’
Authors: Macedo José Marcos , Kölligan Daniel 
Published: October 2019

Abstract
It is argued that Cretan µωλεῖν ‘contend, bring an action to court’ may be derived from PIE *melh3- ‘to go, walk’, attested also in Gk. prs. βλώσκω, aor. ἔµολον, reflecting the frequent usage of motion verbs in legal contexts meaning ‘file a lawsuit’. The derivational basis of µωλέω may have been a thematized root noun *mṓlh3-s ‘going (to court)’ or a vr̥ddhi-formation based on *µολός ‘going’.
Economic Perspective on the Value of Cats and Dogs
Authors: Hoffmann Ruben , Lagerkvist Carl-Johan , Gustavsson Malin Hagberg , Holst Bodil Ström 
Published: October 2019

AbstractAlthough various benefits of cats and dogs have been extensively studied, their fundamental economic value is poorly understood. Economic values are, in contrast to monetary values, determined subjectively and guide individuals in their decisions. This study presents a conceptual economic model of the value of cats and dogs which provides a basis for future research. Benefits of cats and dogs identified in the literature are categorized in relation to the model. The multidimensional value of these nonhuman animals includes different use and non-use values, for caretakers and other humans. Data from an online survey on the salience (importance of attributes in memory) of cats and dogs in Sweden provide support for the proposed model. It is argued that the subjective well-being approach developed in psychology provides a good starting point for estimating many of the economic values of these animals, but that different types of values may require different approaches.