bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protocol of systematic review and meta-analysis of neuromuscular electrical stimulation for interstitial cystitis
Authors: Chen Da-yin , Guo Ying-xue , Dong Long-xin , He Wen-jie , Cao Hui-feng , Wang Ping , Yue Cai-fang 
Published: July 2020

Abstract

Background:
This study will examine the effectiveness and safety of neuromuscular electrical stimulation (NMES) for the treatment of patients with interstitial cystitis (IC).

Methods:
We will retrieve the following electronic databases from their commencements to the March 1, 2020 to discover all related potential studies: MEDLINE, EMBASE, Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and WANFANG Database. Randomized controlled trials related to the NMES for the treatment of patients with IC will be included, regardless publication status and language. Literature selection, data collection, and study quality assessment will be independently performed by 2 authors. The extracted data will be expressed as risk ratio and 95% confidence intervals for dichotomous data, and mean difference or standard mean difference and 95% confidence intervals for continuous data. RevMan V.5.3 software will be employed for statistical analysis.

Results:
This study will summarize current high quality randomized controlled trials to appraise the effectiveness and safety of NMES for the treatment of patients with IC.

Conclusion:
The findings of this study will provide helpful evidence to determine whether NMES is an effective treatment for patients with IC or not.

Systematic review registration:
PROSPERO CRD42020170495.
Identification of novel biomarkers correlated with prostate cancer progression by an integrated bioinformatic analysis
Authors: Ma Zhifang , Wang Jianming , Ding Lingyan , Chen Yujun 
Published: July 2020

Abstract
Prostate cancer (PCa) is a highly aggressive malignant tumor and the biological mechanisms underlying its progression remain unclear.
We performed weighted gene co-expression network analysis in PCa dataset from the Cancer Genome Atlas database to identify the key module and key genes related to the progression of PCa. Furthermore, another independent datasets were used to validate our findings.
A total of 744 differentially expressed genes were screened out and 5 modules were identified for PCa samples from the Cancer Genome Atlas database. We found the brown module was the key module and related to tumor grade (R2 = 0.52) and tumor invasion depth (R2 = 0.39). Besides, 24 candidate hub genes were screened out and 2 genes (BIRC5 and DEPDC1B) were identified and validated as real hub genes that associated with the progression and prognosis of PCa. Moreover, the biological roles of BIRC5 were related to G-protein coupled receptor signal pathway, and the functions of DEPDC1B were related to the G-protein coupled receptor signal pathway and retinol metabolism in PCa.
Taken together, we identified 1 module, 24 candidate hub genes and 2 real hub genes, which were prominently associated with PCa progression. With more experiments and clinical trials, these genes may provide a promising future for PCa treatment.
Successful management of a pregnant woman with Kasabach–Merritt syndrome and preeclampsia
Authors: Yang Yi , Guo Zhiheng , Wang Zhenpeng , Luo Lili , Chen Ying 
Published: July 2020

Abstract

Introduction:
Kasabach-Merritt Syndrome (KMS) is an extremely rare disease in adults, which lead to consumptive coagulopathy characterized by severe hypofibrinogenemia and thrombocytopenia.

Patient concerns:
a 25-year-old Chinese pregnant women complicated by preeclampsia and KMS presented with refractory postpartum hemorrhage and incision bleeding after cesarean section.

Diagnosis:
The diagnosis of KMS was made based on clinical manifestation of Kaposiform Hemangioendothelioma, severe hypofibrinogenemia and thrombocytopenia.

Interventions:
After a poor response to massive blood products transfusion for 1 week, corticosteroid treatment was initiated for 3 days.

Outcomes:
The patient reached a normal platelet count and a mild anemia within 4 weeks. Two months later, all laboratory values had returned to normal, and the incision was healing well.

Conclusion:
Pregnancy complicated by preeclampsia and surgery may have contributions for the development of Kasabach–Merritt syndrome. Corticosteroid is indicated in the episode of acute Kasabach–Merritt syndrome after the failure of massive blood transfusion.
Twin pregnancy outcome following teriflunomide treatment in a relapsing-remitting multiple sclerosis patient
Authors: D’Aleo Giangaetano , Rifici Carmela , Donato Antonina , Corallo Francesco , Di Cara Marcella , Bramanti Placido , Sessa Edoardo 
Published: July 2020

Abstract

Rationale:
Teriflunomide is a disease-modifying drug that has been approved for treatment of relapsing-remitting multiple sclerosis. Due to its teratogenic effect in animals, however, it is not recommended during pregnancy. For this reason, effective contraception must be used during its administration. When an unscheduled pregnancy occurs during therapy, patients must undergo a cholestyramine procedure for rapid flushing of the drug.

Patient concerns:
We describe the case of a 35-year-old female patient suffering diagnosed with relapsing-remitting multiple sclerosis at the age of 20. The patient as a result of side effects of previous therapies started taking teriflunomide.

Diagnosis:
Despite recommendations for the use of contraceptives, the patient became pregnant during drug therapy. Pregnancy occurred 12 months after initiating teriflunomide treatment.

Interventions:
Therapy with teriflunomide was immediately suspended and cholestyramine was prescribed (8 g 3 times a day, for 11 days) to flush out any residual drug from the body.

Outcomes:
Despite an 8-week exposure to teriflumomide during gestation, the patient gave birth to healthy twin girls at 35th week. Controls carried out after birth did not reveal any malformation or genetic and chromosomal abnormality. At a 5-month pediatric specialist check both babies were healthy and growing regularly.

Conclusion:
This shows that even if there is evidence of teratogenic effects in animals, an 8-week exposure to teraflunomide >0.02 mg/L did not have effects on the newborn.
Actual Five-year Survival After Upfront Resection for Pancreatic Ductal Adenocarcinoma
Authors: Strobel Oliver , Lorenz Philipp , Hinz Ulf , Gaida Matthias , König Anna-Katharina , Hank Thomas , Niesen Willem , Kaiser J.ö.rg , Al-Saeedi Mohammed , Bergmann Frank , Springfeld Christoph , Berchtold Christoph , Diener Markus K. , Schneider Martin , Mehrabi Arianeb , Müller-Stich Beat P. , Hackert Thilo , Jager Dirk , Büchler Markus W. 
Published: July 2020

Objective:
To determine actual five-year survival (5YS) rates associated with a strategy of upfront surgery and adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC).

Background:
The rate of actual 5YS in PDAC remains controversial. Available data is restricted to cohorts acquired over several decades and series of resection after patient selection by neoadjuvant therapy.

Methods:
All patients undergoing upfront resection for resectable and borderline-resectable PDAC from 10/2001 to 12/2011 were identified from a prospective database. Actual overall survival was assessed after a follow-up of at least 5 years. Uni- and multivariable logistic regression analyses were performed.

Results:
Median survival of 937 patients was 22.1 months. The actual 5YS rate was 17.0% (n = 159) including 89 (9.5%) patients without evidence of disease >5 years after resection. 5YS rates in patients with or without adjuvanttherapy were 18.8% vs. 12.2%, respectively. Tumorgrading, number of positive lymph nodes, a context of intraductal papillary mucinous neoplasia, and vascular resections were independently associated with 5YS. Patient-related parameters and CA 19-9 levels were associated with observed survival up to 3 years, but lost relevance thereafter. The extent of lymph node involvement was the strongest predictor of 5YS. Patients with pN0R0 had a 5YS rate of 38.2%. in patients with exclusively favorable factors the observed 5YS rate was above 50%.

Conclusions:
This is the largest series of long-term survivors with histologically confirmed PDAC. With upfront resection and adjuvant therapy an actual overall 5YS rate of 18.8% can be expected. in favorable subgroups actual 5YS is above 50%.
Ethics of Facial Transplantation
Authors: ElHawary Hassan , Salimi Ali , Gilardino Mirko S. 
Published: July 2020

Objective:
This study examines and contrasts the effect of risk disclosure on risk acceptance and perceived changes in quality of life (QoL) among individuals with and without facial disfigurement.

Summary of Background Data:
Psychological distress has been previously shown to alter patients’ perception of certain treatments. Due to the grave risks and complications of FT, it is important to understand whether the psychological trauma associated with facial disfigurement alters their perception of FT and its associated risks.

Methods:
Participants with and without facial disfigurement were recruited to complete a questionnaire about their perceived QoL, sense of identity, and willingness to proceed with FT in the context of 3 different hypothetical scenarios involving facial disfiguration.

Results:
Four hundred nine nonfacially disfigured and 74 facially disfigured participants were included. When both healthy and facially disfigured individuals were presented with the risks and benefits of a FT, they both perceived their QoL to be as low, or significantly lower, than if they had severe facial disfigurement. Furthermore, presenting the risks of FT significantly altered the decision making and risk acceptance of healthy individuals with no facial disfigurement. However, risk disclosure did not affect the decision making among facially disfigured individuals.

Conclusion:
This study highlights that presenting the complication profile of FT decreases risk acceptance of FT in healthy individuals but has no significant effects on facially disfigured individuals. The psychological impact of facial disfigurement and its influence on accepting the significant risks of FT should be considered and warrants further investigation.
The impact of epidemics on agricultural production and forecast of COVID-19
Authors: Zhang Shurui , Wang Shuo , Yuan Lingran , Liu Xiaoguang , Gong Binlei 
Published: July 2020

PurposeThis article investigates the mechanism of the direct and indirect effects of epidemics on agricultural production and projects the impact of COVID-19 on agricultural output in China.Design/methodology/approachThis article first adopts a dynamic panel model and spatial Durbin model to estimate the direct and indirect effects, followed by a growth accounting method to identify the channels by which epidemics affect agriculture; finally, it projects the overall impact of COVID-19 on agriculture.FindingsThe incidence rate of epidemics in a province has a negative impact on that province's own agricultural productivity, but the increase in the input factors (land, fertilizer and machinery) can make up for the loss and thus lead to insignificant direct effects. However, this “input-offset-productivity” mechanism fails to radiate to the surrounding provinces and therefore leads to significant indirect/spillover effects. It is projected that COVID-19 will lower China's agricultural growth rate by 0.4%–2.0% in 2020 under different scenarios.Research limitations/implicationsIt is crucial to establish a timely disclosure and sharing system of epidemic information across provinces, improve the support and resilience of agricultural production in the short run and accelerate the process of agricultural modernization in the long run.Originality/valueConsidering the infectivity of epidemics, this article evaluates the mechanism of the direct and indirect effects by introducing a spatial dynamic model into the growth accounting framework. Moreover, besides the impact on input portfolio and productivity, this article also investigates whether epidemics reshape agricultural production processes due to panic effects and control measures.
Cause-related marketing in international business: what works and what does not?
Authors: Vrontis Demetris , Thrassou Alkis , Christofi Michael , Shams Riad , Czinkota Michael R. 
Published: July 2020

PurposeThe purpose of this paper is to investigate the irrevocable role of cause-related marketing (CRM) and its research imperative, exploring its contemporary insights in and across international markets, toward scholarly and executive application.Design/methodology/approachThis research is theoretical and it compiles and interrelates, in a multiperspective fashion, significant extant works in the field; focusing on how established and emergent variables and constructs can be leveraged, in order to develop insights into what does and does not work in international CRM.FindingsExtant works on international CRM still present significant gaps pertaining to key questions. Furthermore, true understanding of CRM stems from comprehending consumers, both individually and collectively; and both their underlying and contextual motivators, factors and forces. This calls for a multiperspective and cross-disciplinary approach to CRM to that weaves in contextual (sociocultural, etc.) elements to the equation.Research limitations/implicationsLimitations naturally pertain to the research's theoretical nature that requires empirical testing.Practical implicationsCRM offers consumers both the means and the ends of acquiring their target core value benefits, additionally or peripherally to their core purchase purpose; potentially making the difference between business/brand success and failure.Social implicationsThrough CRM, the contemporary consumer seeks product value benefits that transcend quality and functionality (etc.), to engulf abstract and intangible values pertaining to social, ethical, self-image and self-actualization factors.Originality/valueThe comprehensive review, contextual elucidations and cross-disciplinary perspectives of this paper originally present the scope, depth, complexity and gaps of the subject, and pave the way for the research that still needs to ensue.
Effect of transformational leadership on job performance: testing the mediating role of corporate social responsibility
Authors: K Jnaneswar , Ranjit Gayathri 
Published: July 2020

PurposeEncouraging employees to bolster their performance in today's turbulent business environment is an important priority for all types of organizations. Even though few studies reported the impact of transformational leadership (TL) on job performance (JP), the role of mediators namely corporate social responsibility (CSR) in this relationship is not given due attention. The purpose of this paper is to assess the mediating role of CSR in the relationship between TL and JP in the Indian context.Design/methodology/approachData from 306 full time employees working in the manufacturing industry in India were collected through an online survey. The manufacturing organizations were selected on the basis of their active participation in CSR activities and robustness of HR practices. Three structured questionnaires were used for eliciting data from the employees, and AMOS software was used for testing the validity of the hypothesized model. PROCESS macro was used for testing the mediating role of CSR.FindingsTL impacted both JP and CSR. Additionally, CSR showed a positive relationship with JP of employees. The pivotal finding of the study is the partial mediation of CSR in the TL–JP relationship.Originality/valueBased on neo-charismatic paradigm theory, TL theory, stakeholder theory and social identity theory, this paper enriches the literature by demonstrating the mediation mechanism driving TL and JP relationship.
How resilient are REITs to a pandemic? The COVID-19 effect
Authors: Akinsomi Omokolade 
Published: July 2020

PurposeReal estate investment trusts (REITs) are historically considered as attractive assets to investors particularly as the underlying assets are properties which are income-producing. REITs also distribute substantial amount of profits as dividends to shareholders. Stephen and Simon (2005) find that REITs in a mixed asset portfolio of stocks and bonds enhance returns and reduce risk. This paper examines the role a pandemic (COVID-19) plays in the performance of global REITs index and REIT sectors.Design/methodology/approachTo examine the effects of COVID-19 on REITs, the year-to-date (YTD) returns of global returns index and REITs sectors in the United States are observed and a comparative analysis is employed from January 2020 to May 2020.FindingsBased on a three-month return ending 22 May 2020, FTSE EPRA NAREIT index is the biggest loser at −31.83% whilst the FTSE EPRA Asia–Pacific index has the lowest loss at −23.20%. The author examines YTD returns which show disparities on the effect of COVID-19 on REIT sectors. The US market is examined; most REIT sectors suffered big losses as at April 2020; the analysis reveals YTD returns for the top three REIT sector losers are lodging/resort REITs (−45.81%), retail REITs (−41.16%) and office REITs (−22.63%). Data centre REITs are the only sector REITs with positive returns at 17.66%.Practical implicationsMost sector REITs during the pandemic have lost considerable value based on YTD returns as at May 2020. Flight to quality is expected during this uncertain period to REITs such as data REITs, grocery-anchored REITs and storage REITs. These REITs are not as adversely affected by COVID-19 in comparison to other REITs.Originality/valueThis paper identified the impact of COVID-19 on the performance of global REITs and US sector REITs during the periods from January 2020 to May 2020.
Deep learning for population size history inference: Design, comparison and combination with approximate Bayesian computation
Authors: Sanchez Théophile , Cury Jean , Charpiat Guillaume , Jay Flora 
Published: July 2020

AbstractFor the past decades, simulation‐based likelihood‐free inference methods have enabled researchers to address numerous population genetics problems. As the richness and amount of simulated and real genetic data keep increasing, the field has a strong opportunity to tackle tasks that current methods hardly solve. However, high data dimensionality forces most methods to summarize large genomic data sets into a relatively small number of handcrafted features (summary statistics). Here, we propose an alternative to summary statistics, based on the automatic extraction of relevant information using deep learning techniques. Specifically, we design artificial neural networks (ANNs) that take as input single nucleotide polymorphic sites (SNPs) found in individuals sampled from a single population and infer the past effective population size history. First, we provide guidelines to construct artificial neural networks that comply with the intrinsic properties of SNP data such as invariance to permutation of haplotypes, long scale interactions between SNPs and variable genomic length. Thanks to a Bayesian hyperparameter optimization procedure, we evaluate the performance of multiple networks and compare them to well‐established methods like Approximate Bayesian Computation (ABC). Even without the expert knowledge of summary statistics, our approach compares fairly well to an ABC approach based on handcrafted features. Furthermore, we show that combining deep learning and ABC can improve performance while taking advantage of both frameworks. Finally, we apply our approach to reconstruct the effective population size history of cattle breed populations.
What exactly is missing here? The sensory processing of unpredictable omissions is modulated by the specificity of expected action‐effects
Authors: Korka Betina , Schröger Erich , Widmann Andreas 
Published: July 2020

AbstractWe select our actions according to the desired outcomes; for instance, piano players press certain keys to generate specific musical notes. It is well‐described that the omission of a predicted action‐effect may elicit prediction error signals in the brain, but what happens in the case of simultaneous effector‐specific (by contrast to effector‐unspecific) predictions? To answer this question, we asked participants to press left and right keys to generate tones A and B; based on the action‐effect association, the tones’ identity was either predictable or unpredictable, while rarely, the expected input was omitted. Crucially, the data show that omissions following hand‐specific associations reliably elicited a late omission N1 (oN1) component, by contrast to the hand‐unspecific associations, where the late oN1 was rather weak. An additional condition where both key‐presses generated a unique tone was implemented. Here, rare omissions of the expected tone generated both early and late oN1 responses, by contrast to the condition in which two simultaneous action‐effect representations had to be maintained, where only late oN1 responses were elicited. Finally, omission P3 (oP3) responses were strongly elicited for all omission types without differences, indicating that a general expectation based on a tone presentation (rather than which tone), is likely indexed at this stage. The present results emphasize the top‐down effects of action intention on the sensory processing of omissions, where unspecific (vs. specific) and multiple (vs. single) action‐effect representations are associated with processing costs at the early sensory levels.
Towards a standardization of soil‐related ecosystem service assessments
Authors: Paul Carsten , Kuhn Kristin , Steinhoff‐Knopp Bastian , Weißhuhn Peter , Helming Katharina 
Published: July 2020

AbstractThe concept of ecosystem services (ES) creates understanding of the value of ecosystems for human well‐being. With regard to soils, it provides a framework for assessments of soil contributions and soil management impacts. However, a lack of standardization impedes comparisons between assessment studies and the building of synthesis information. The Common International Classification of Ecosystem Services (CICES) is an important step forward, although its application to soils is not without difficulty. CICES version 5.1 defines 83 ES classes, of which only some are relevant for soils. We compiled two subsets of CICES classes: one set of soil‐related ES comprising 29 services defined as directly and quantifiably controlled by soils and their properties, processes and functions, and another set of 40 ES defined as being affected by agricultural soil management. Additionally, we conducted a systematic literature review, searching for published lists of soil‐related ES that claim completeness. We identified 11 relevant lists. Of all CICES classes, 12 were included in more than 75% of the lists, whereas another 36 classes were included in 25–75% of them. Regarding the suitability of the CICES classification for addressing ES in the context of soils and their agricultural management, we identified constraints, such as overlaps, gaps, and highly specific or very broad class definitions. Close cooperation between the soil research and ES communities could ensure better consideration of soils in future CICES updates. A shortlist of 25 service classes affected by agricultural soil management facilitates a standardized approach and may function as checklists in impact assessments.Highlights
Standardized definitions are needed to allow meta‐analysis of ecosystem service studies and improve assessments.
CICES defines 83 detailed classes of ecosystem services, suggested as a “default list”.
We identified 29 classes as soil related and 40 classes as affected by agricultural soil management.
Both subsets facilitate ecosystem service assessments in soil research and comparability of results.