bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modèles animaux sensibles aux antidépresseurs: implication des systèmes sérotoninergiques et noradrénergiques centraux
Authors: Martin P , Thiébot MH , Puech AJ 
Published: April 2020

RésuméTenter de vouloir modéliser chez l’animal une pathologie psychiatrique peut sembler tout à fait illusoire. Il est en revanche plus aisé d’analyser «les grandes fonctions» qui modulent le comportement, ainsi que les systèmes neurobiologiques impliqués dans leur régulation. À travers deux tests comportementaux sensibles aux antidépresseurs: le modèle de «Learned Helplessness» ou «renoncement appris» et le test du labyrinthe en T, mesurant une capacité à attendre; nous avons voulu montrer que les effets de substances antidépressives pouvaient agir sur deux dimensions différentes et de quelle(s) manière(s) pouvaient être impliqués les systèmes sérotoninergiques.
Sérotonine et dépression: psychopathologie dimensionnelle
Authors: Lecrubier Y , Aloupis P 
Published: April 2020

RésuméL’approche nosologique - classique en psychiatrie - n’est plus pertinente pour la dépression. Des paramètres biologiques mettent en évidence l’existence de différentes dimensions dans cette pathologie, dont certaines, liées à des modifications du fonctionnement sérotoninergique, sont sensibles à des produits modifiant ce fonctionnement. Le fait que le traitement de patients obsessionnels par benzodiazépines apporte une amélioration de la symptomatologie anxieuse s’exprimant au niveau neurovégétatif mais a tendance à aggraver les obsessions donne à penser que le médicament reste un des meilleurs outils pour une identification pertinente de dimensions transnosologiques.
Onset of panic disorder and suicide attempts
Authors: Lepine JP , Chignon JM , Teherani M 
Published: April 2020

SummaryIn a study of the general population, Weissman et al (1989), found that panic disorder is associated with an increased risk of suicide attempt. We estimated the lifetime prevalence of suicidal ideations or suicide attempts in 100 consecutive referrals for treatment of panic disorder. Sixty per cent of these patients had had suicidal ideation and 42% had attempted suicide during their lifetime. With regard to the season of onset of panic attack, we found a very skewed distribution of first panic in late spring or summer. Furthermore, patients who had their first attack in spring or summer had a higher rate of suicidal ideation and an increased risk of suicide attempt.
Genetic Research in Psychiatry: Update from the Society of Biological Psychiatry and the American Psychiatric Association, New York, May 1990
Authors: Crocq MA , Duval F , Macher JP 
Published: April 2020

SummaryA stimulating variety of papers on genetic and clinical research in psychiatry was discussed at the latest meeting of the American Psychiatric Association and the Society of Biological Psychiatry in May 1990 in New York. Conflicting results point out that extreme caution must be taken in interpreting linkage studies of psychiatric disorders. Difficulties stem from complex models on inheritance as well as the genetic heterogeneity of psychiatric disorders. Progress has been made in the approach to the regulation of receptor genes that have been implicated in the pathogenesis of psychiatric disorders. In some cases, gene regulation may be tissue-dependent, as is suggested by the alternative splicing of D2 receptor mRNA.
Attaques de panique et agoraphobie: rôle du stress et des événements de vie. Revue de la littérature à propos de deux cas
Authors: Auriacombe M , Tignol J 
Published: April 2020

RésuméLes auteurs rapportent deux cas cliniques illustratifs du trouble panique avec agoraphobie pour l’un, et sans agoraphobie pour l’autre. Les observations cliniques sont confrontées aux critères du DSM III-R. La symptomatologie présentée dans les deux cas cliniques survient à la suite d’un stress chronique et de difficultés d’ajustement. Cependant, l’attaque de panique est considérée par ses inventeurs comme l’expression d’un dysfonctionnement neuro-biologique primaire. À cette occasion les auteurs font une revue exhaustive de la littérature quant au rôle des événements de vie dans la survenue du trouble panique avec ou sans agoraphobie. S’il apparaît démontré qu’il existe des événements de vie précédant la survenue de troubles anxieux (11 études publiées depuis 1980), la question de leur spécificité vis-à-vis des troubles anxieux paroxystiques n’est pas clairement établie ou est réfutée. Il semblerait qu’il n’y ait pas d’excès d’événements de vie chez les patients avec attaques de panique par rapport aux patients anxieux sans attaques de panique. Cependant les patients anxieux avec attaque de panique semblent avoir un vécu qualitativement particulier des événements de vie par le degré de stress et de détresse qu’ils y associent.
Facteurs prédisposants à la survenue d'une pathologie dépressive au cours du post-partum
Authors: Blanchon Y.C. , Grenier M.P. , Bourgeois F. , Pellet J. , La Selve A. , Nury A.M 
Published: April 2020

RésuméCet article présente brièvement les résultats d’une étude épidémiologique unicentrique standardisée avec seulement deux cotateurs entraînés, de l’incidence et des facteurs de morbidité des épisodes dépressifs non psychotiques de la puerpéralité à partir de 483 dossiers standardisés de jeunes accouchées constituant un échantillon au tiers parmi les 1232 accouchements survenus durant une année à la maternité du CHRU de Saint-Etienne. Ce travail a permis de diagnostiquer au moyen d’évaluations psychométriques quantifiées 35 cas de “post partum blues” (incidence 6.6 %). Le dépouillement des réponses aux 35 items (Tableau 1) a permis d’isoler par segmentation non arborescente (figure 1) deux groupes: un de femmes non-à-risque et un de femmes à haut risque de pathologie dépressive post puerpérale défini par la présence de quatre facteurs prédisposants: la présence d’antécédants psychopathologiques personnels dépressifs, la survenue de manifestations anxiodépressives et de traumatismes psychologiques durant la grossesse, la séparation précoce d’avec l’enfant après l’accouchement. Quant aux “post partum blues”, seule la primiparité apparaît avec une plus grande fréquence. Néanmoins leur faible incidence dans notre échantillon peut conduire à s’interroger sur la définition des critères de morbidité de cette pathologie.
Editorial endeavours: plainchant revision in early modern Italian printed graduals
Authors: GILLION MARIANNE C.E. 
Published: April 2020

ABSTRACTThe extensive melodic revision of plainchant in editions of theGraduale Romanumpublished in Italy from the late sixteenth century onward resulted in musically diverse repertoires that could depart widely from earlier chant traditions. The scale of the changes in these sources, both in type and in number, has obscured certain aspects of their editors’ work: their familiarity with the corpus, their aims and techniques, and their approach to the task. Previous analyses concluded that the editors worked on a chant-by-chant basis, and were either unaware of or ignored any shared melodic relationships between pieces of plainchant. An examination of the revisions to the recurrent melody used by the eightOstendealleluias in three influential Italian printed graduals – Gardano 1591, Giunta 1596 and Medici 1614/15 – provides a different perspective. Analyses of the reshaped chants reveal that the editors possessed knowledge of the repertoire guiding aims, and favoured revision techniques. The combination of these factors, whether intentionally or not, resulted in the chants’ continued structural connection in the midst of increased melodic diversity. The individuation evident the chants did not necessarily signal the editors’ unfamiliarity with the repertoire, but could have been indicative of their intentional rejection of shared elements. Further, the revisions to theOstendealleluias reveal that the editorial process could be flexible, with the chants approached both as individual entities and as groups. These findings demonstrate the complexity of the editorial process in early modern Italian printed graduals, and deepen our understanding of this multifaceted repertoire.
Double Dissociation of Auditory Attention Span and Visual Attention in Long-Term Survivors of Childhood Cerebellar Tumor: A Deterministic Tractography Study of the Cerebellar-Frontal and the Superior Longitudinal Fasciculus Pathways
Authors: Ailion Alyssa S. , King Tricia Z. , Roberts Simone R. , Tang Brian , Turner Jessica A. , Conway Christopher M. , Crosson Bruce 
Published: April 2020

AbstractObjective:Right cerebellar-left frontal (RC-LF) white matter integrity (WMI) has been associated with working memory. However, prior studies have employed measures of working memory that include processing speed and attention. We examined the relationships between the RC-LF WMI and processing speed, attention, and working memory to clarify the relationship of RC-LF WMI with a specific cognitive function. Right superior longitudinal fasciculus II (SLF II) WMI and visual attention were included as a negative control tract and task to demonstrate a double dissociation.Methods:Adult survivors of childhood brain tumors [n= 29, age:M= 22 years (SD= 5), 45% female] and demographically matched controls were recruited (n= 29). Tests of auditory attention span, working memory, and visual attention served as cognitive measures. Participants completed a 3-T MRI diffusion-weighted imaging scan. Fractional anisotropy (FA) and radial diffusivity (RD) served as WMI measures. Partial correlations between WMI and cognitive scores included controlling for type of treatment.Results:A correlational double dissociation was found. RC-LF WMI was associated with auditory attention (FA:r= .42,p= .03; RD:r= −.50,p= .01) and was not associated with visual attention (FA:r= −.11,p= .59; RD:r= −.11,p =.57). SLF II FA WMI was associated with visual attention (FA:r= .44,p= .02; RD:r= −.17,p= .40) and was not associated with auditory attention (FA:r= .24,p= .22; RD:r= −.10,p= .62).Conclusions:The results show that RC-LF WMI is associated with auditory attention span rather than working memoryper seand provides evidence for a specificity based on the correlational double dissociation.
Military Resistance to the Brazilian Coup:The Fight of Officers and Soldiers against Authoritarian Rule, 1964–67
Authors: Corrêa Marilia 
Published: April 2020

ABSTRACTThis article traces resistance among members of the armed forces who opposed the military dictatorship in Brazil during the first four years of the regime, 1964–67. I show that despite scholars’ efforts to depict the 1964 coup as a project supported by the armed forces as a strategic and ideological unit, there were battle lines within those forces along which hard-liners and moderate interventionists battled for government control. There were, in fact, hundreds of officers and soldiers who opposed the coup and organized against it. To contain resistance efforts inside the armed forces, the generals who orchestrated the coup labeled opponents to intervention as communists and expelled them from the institution, in many cases under considerable duress. This article discusses the first opposition efforts of officers and soldiers, particularly the Nationalist Armed Resistance (RAN) and the Caparaó Guerrilla Movement. Members of the military who were opposed to the coup shared an anti-interventionism and nationalism that united them against the regime. After 1964, their efforts to oppose military interventionism, previously carried out inside the military barracks, became the fight of all its opponents, members of the armed forces and civilians alike.
Validierung eines interaktiven Abstimmungssystems zur Diagnose psychischer Belastung mittels KFZA
Authors: Prümper Jochen , Schneeberg Tom 
Published: April 2020

Zusammenfassung. Stellt ein elektronisches Votingsystem (EVS) auf Basis des KFZA (Kurz-Fragebogen zur Arbeitsanalyse) eine Alternative zu dem klassischen „Papier & Bleistift“-Erhebungszenario (P&B) dar und entspricht es den Anforderungen der EN ISO 10075 – 3 (2004) ? Um zu testen, ob EVS an einer österreichischen Stichprobe ( N = 43) zu vergleichbaren Ergebnissen wie die „P&B“-Befragung mittels KFZA führt, nahm jede Probandin und jeder Proband an drei Versuchsbedingungen 1. P&B Einzel, 2. P&B in Gruppe und 3. EVS in Gruppe mit randomisierter Reihenfolge teil. Die Methodenübereinstimmung wurde durch die ICC der KFZA-Skalen und mit einem Bland-Altman-Plot für den KFZA-Gesamtwert beurteilt. Die ICC zeigen gute bis mehrheitlich exzellente Übereinstimmungen (KFZAgesamt = .966). Es bestehen keine signifikanten systematischen Abweichungen zwischen den Erhebungsmethoden. EVS dauerte mit 16 Minuten zwar 10 Minuten länger als P&B, aber die Gebrauchstauglichkeit wurde bedeutsam besser beurteilt. Die Studie zeigt trotz ihrer Limitationen wie die praktische Umsetzung zur Bewertung von elektronischen Messverfahren zur Diagnose psychischer Belastung erfolgen kann.
The Role of Personal Factors and Learning Environment in Suicidal Ideation Among Tunisian Medical Students
Authors: Fekih-Romdhane Feten , ElKhouni Chams , Sassi Hadhami , Cheour Majda 
Published: April 2020

Abstract. Objective: Little is known about specific professional factors influencing medical students' suicidal ideation and behavior. We aimed to evaluate the prevalence and correlates of suicidal ideation in Tunisian medical students. Method: This was a cross-sectional study; 390 second-cycle medical students were enrolled at the Faculty of Medicine of Tunis. Participants responded to an anonymous questionnaire containing sociodemographic data, educational factors, the Suicidal Ideation Questionnaire (SIQ), and the Depression, Anxiety and Stress scales (DASS-21). Results: Eleven students (2.8%) had made one or more suicide attempts in their lifetime. For a threshold value of 41 based on the SIQ scale, 7.9% of students were considered to have a potential risk of suicide. The multiple hierarchical linear regression analysis identified as main factors independently associated with suicidal ideation: tobacco consumption, perceived sleep quality, depression symptoms, the personal history of suicide attempt, the satisfaction with student–supervisor relationship, and choosing to study medicine. Conclusion: Suicide prevention efforts should target high-risk students with prior personal or family history of suicidal behavior. Moreover, medical school authorities should put in place effective strategies to optimize the learning environment at their institutions.
LipidCreator workbench to probe the lipidomic landscape
Authors: Peng Bing , Kopczynski Dominik , Pratt Brian S. , Ejsing Christer S. , Burla Bo , Hermansson Martin , Benke Peter Imre , Tan Sock Hwee , Chan Mark Y. , Torta Federico , Schwudke Dominik , Meckelmann Sven W. , Coman Cristina , Schmitz Oliver J. , MacLean Brendan , Manke Mailin-Christin , Borst Oliver , Wenk Markus R. , Hoffmann Nils , Ahrends Robert 
Published: April 2020

AbstractMass spectrometry (MS)-based targeted lipidomics enables the robust quantification of selected lipids under various biological conditions but comprehensive software tools to support such analyses are lacking. Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope labeling, optimize collision energy and generate in silico spectral libraries. We validate LipidCreator assays computationally and analytically and prove that it is capable to generate large targeted experiments to analyze blood and to dissect lipid-signaling pathways such as in human platelets.
A multidecadal assessment of climate indices over Europe
Authors: Domínguez-Castro Fernando , Reig Fergus , Vicente-Serrano Sergio M. , Aguilar Enric , Peña-Angulo Dhais , Noguera Iván , Revuelto Jesús , van der Schrier Gerard , El Kenawy Ahmed M. 
Published: April 2020

AbstractMonitoring and management of several environmental and socioeconomic sectors require climate data that can be summarized using a set of standard and meaningful climate metrics. This study describes a newly developed gridded dataset for the whole of Europe, which employed a set of 125 climate indices spanning different periods based on data availability, but mainly 1950–2017 and 1979–2017. This dataset comprehensively summarizes climate variability in Europe for a wide range of climate variables and conditions, including air temperature, precipitation, biometeorology, aridity, continentality, drought, amongst others. Climate indices were computed at different temporal scales (i.e. monthly, seasonal and annual) and mapped at a grid interval of 0.25°. We intend to update these indices on an annual basis. This dataset is freely available to research and end-user communities.
weg2vec: Event embedding for temporal networks
Authors: Torricelli Maddalena , Karsai Márton , Gauvin Laetitia 
Published: April 2020

AbstractNetwork embedding techniques are powerful to capture structural regularities in networks and to identify similarities between their local fabrics. However, conventional network embedding models are developed for static structures, commonly consider nodes only and they are seriously challenged when the network is varying in time. Temporal networks may provide an advantage in the description of real systems, but they code more complex information, which could be effectively represented only by a handful of methods so far. Here, we propose a new method of event embedding of temporal networks, calledweg2vec, which builds on temporal and structural similarities of events to learn a low dimensional representation of a temporal network. This projection successfully captures latent structures and similarities between events involving different nodes at different times and provides ways to predict the final outcome of spreading processes unfolding on the temporal structure.
The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells
Authors: Mészáros Beáta , Papp Ferenc , Mocsár Gábor , Kókai Endre , Kovács Katalin , Tajti Gabor , Panyi Gyorgy 
Published: April 2020

AbstractThe voltage-gated proton channel Hv1 is widely expressed, among others, in immune and cancer cells, it provides an efficient cytosolic H+extrusion mechanism and regulates vital functions such as oxidative burst, migration and proliferation. Here we demonstrate the presence of human Hv1 (hHv1) in the placenta/chorion-derived mesenchymal stem cells (cMSCs) using RT-PCR. The voltage- and pH-dependent gating of the current is similar to that of hHv1 expressed in cell lines and that the current is blocked by 5-chloro-2-guanidinobenzimidazole (ClGBI) and activated by arachidonic acid (AA). Inhibition of hHv1 by ClGBI significantly decreases mineral matrix production of cMSCs induced by conditions mimicking physiological or pathological (inorganic phosphate, Pi) induction of osteogenesis. Wound healing assay and single cell motility analysis show that ClGBI significantly inhibits the migration of cMSCs. Thus, seminal functions of cMSCs are modulated by hHv1 which makes this channel as an attractive target for controlling advantages/disadvantages of MSCs therapy.
Pore structure and its impact on susceptibility to coal spontaneous combustion based on multiscale and multifractal analysis
Authors: Yu Zhang , Xueqing Zhang , Wen Yang , Haihui Xin , Sherong Hu , Yu Song 
Published: April 2020

AbstractThe relationship between the properties of coal and its tendency to spontaneous combustion is critical for the environment, safety concerns, and economy. In this study, to eliminate the complex influence of moisture; the samples having similar moisture content were selected from Shanxi and Henan provinces. The chemical properties, physical properties, and tendency of coal samples to spontaneous combustion were characterized based on the conventional analysis, mercury intrusion porosimetry, fractal dimensions, and crossing point temperature (CPT). The results confirmed that the coal rank, volatile matter, oxygen contents, and fixed carbon content had a good linear relationship with the CPT. The relationship between the ash content and CPT presented a “U-shaped” non-linear correlation. For the pore size distribution, the total pore volume also possessed a linear positive correlation with the CPT. The fractal curves could be distinctly divided into two stages: low-pressure (<20 MPa) and high-pressure (>20 MPa), from which the fractal dimensions were obtained using the Sponge and Sierpinski models. The relationship between the fractal dimensions (Ds1, Ds2, and Dg1) and CPT could be divided into two distinct stages: a decrease in the CPT with increasing fractal dimensions (2.6–2.85), and then an in increase in the CPT. CPT decreased with increasing parameters of D1, D2, H, and D10, and it gradually increased with increasing D-10-D10, D-10-D0, and D0-D10. The above characteristics are important to comprehensively and systematically reveal the mechanism of spontaneous combustion.
Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis
Authors: Nagrani Rajini , Foraita Ronja , Gianfagna Francesco , Iacoviello Licia , Marild Staffan , Michels Nathalie , Molnár Dénes , Moreno Luis , Russo Paola , Veidebaum Toomas , Ahrens Wolfgang , Marron Manuela 
Published: April 2020

AbstractAs the prevalence of metabolic syndrome (MetS) in children and young adults is increasing, a better understanding of genetics that underlie MetS will provide critical insights into the origin of the disease. We examined associations of common genetic variants and repeated MetS score from early childhood to adolescence in a pan-European, prospective IDEFICS/I.Family cohort study with baseline survey and follow-up examinations after two and six years. We tested associations in 3067 children using a linear mixed model and confirmed the results with meta-analysis of identified SNPs. With a stringent Bonferroni adjustment for multiple comparisons we obtained significant associations(p < 1.4 × 10−4) for 5 SNPs, which were in high LD (r2 > 0.85) in the 16q12.2 non-coding intronic chromosomal region of FTO gene with strongest association observed for rs8050136 (effect size(β) = 0.31, pWald = 1.52 × 10−5). We also observed a strong association of rs708272 in CETP with increased HDL (p = 5.63 × 10−40) and decreased TRG (p = 9.60 × 10−5) levels. These findings along with meta-analysis advance etiologic understanding of childhood MetS, highlighting that genetic predisposition to MetS is largely driven by genes of obesity and lipid metabolism. Inclusion of the associated genetic variants in polygenic scores for MetS may prove to be fundamental for identifying children and subsequently adults of the high-risk group to allow earlier targeted interventions.