bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpretation of Electromagnetic Wave Penetration and Absorption for Different Reservoir Mineralogy Quartz-Rich, Limestone-Rich, and Clay-Rich and at High and Low Water Saturation Values for a Bitumen Reservoir
Authors: Morte Matthew , Alhafidh Hasan , Hascakir Berna 
Published: September 2020

Abstract
Electromagnetic (EM) waves are used in the oil and gas industry to identify the geology of the formation and the type of the fluid saturating the medium. There is also an interest to use the electromagnetic waves as an enhanced oil recovery (EOR) method. However, interpretation of logging data generated through electromagnetic waves or determination of the electromagnetic wave propagation in a medium as an EOR method are not easy tasks. This study aims to identify the role of different geological settings with different types of fluid saturations in the response of electromagnetic wave propagation and absorption.
To reach this objective multitude-systematic laboratory scale experiments were conducted on different reservoirs fluid and rock pairs. As reservoir mineralogy, different grain size of quartz, clay, or limestone is used to prepare the reservoir rocks at different porosity. Water is known as a good absorber for EM waves, thus, pore space were saturated at different water saturations and a bitumen sample (10,000 cP, 12° API) from Canada. Prepared samples were packed into in-house-built-Plexiglas core holder which allows measurements with EM waves. The response of EM waves propagation and absorption was measured by using a vector network analyzer at varying frequencies (500 MHz to 4 GHz) through dielectric properties (dielectric constant, loss tangent, and penetration depth). The results were used to obtain correlations between dielectric properties and physical properties (reservoir rock mineralogy, porosity, water saturation, and oil saturation) of the reservoir rock-fluid blends.
Water saturation gives a perfect correlation with dielectric constant and loss tangent values of the saturated medium. Because dielectric constant and loss tangent parameters provide an idea on the absorption characteristics of EM wave in the medium, and because water is a strong EM wave absorber, as it was expected, with the increase in water saturation, the dielectric constant and loss tangent parameters of the medium are also increased; on the other hand, penetration depth was decreased. With the increase in quartz content in the medium, it has been observed that EM wave penetration is enhanced.
As a result, several correlations were created in this study and they can be used to better interpret the reservoir mineralogy and fluid saturation as a response to EM wave logging. Moreover, these results can be used to estimate the effective area (penetration depth) of EM wave as an EOR method in different mediums.
Acute and Long-term Effects of Saxagliptin on a Set of Cardiovascular Targets Measured at Fasting and Post-prandially in Obese Patients With Impaired Glucose Tolerance: a Randomized, Placebo-controlled, Double-blind Study
Authors: Rezki Amel , Cosson Emmanuel , Fysekidis Marinos , Chiheb Sabrina , Vicaut Eric , Valensi Paul 
Published: September 2020

Abstract
Background: Studies of dipeptidyl peptidase inhibitors (DPP4is) report heterogeneous effects on cardiovascular targets in type 2 diabetes. Little is known about the cardiovascular effects of DPP4is in patients with impaired glucose tolerance (IGT) in particular during the post-prandial state. Methods: In this randomized, placebo-controlled, double-blind, single-center pilot study, we included obese individuals with IGT. Participants were randomized to receive for 12 weeks either saxagliptin 5mg a day or placebo. They were explored non-invasively before and after a standardized breakfast for biological markers; microcirculatory blood flow at baseline and after transcutaneous administration of acetylcholine (Periflux System 5000® PERIMED); post-occlusive digital reactive hyperhemia (Endopat2000®); pulse wave velocity, augmentation index, central pulse pressure and subendocardial viability ratio (Sphygmocor®); cardiac hemodynamic parameters and cardiovascular autonomic nervous system activity (Task force monitor®). Results: We investigated 24 individuals (mean body mass index 36.8±4.8 kg/m2, hypertension 33.3%). The results of all the investigations were similar after breakfast in the two groups at Visit 1 (acute post-prandial effects, after the first tablet) and Visit 2 (long-term post-prandial effects), and at fasting at Visit 1 and 2 (long-term effects, after 12 weeks of treatment). Only at Visit 2 the decrease in cardiac vagal activity occurring after breakfast was more sustained in the saxagliptin group than in the placebo group (interaction between treatment and time effect: p=0.016).Conclusion: In obese patients with IGT, among the large set of cardiovascular parameters we measured in the fasting and post-prandial state, the unique change induced by saxagliptin consisted in a more marked post-prandial depression of vagal activity. Clinical Trial Registration number: NCT01521312
Antimicrobial Susceptibility of Porphyromonas Gingivalis Strains Isolated From Periodontal Patients by Three Testing Protocols
Authors: Isbej Lorena , Oyarzo Natacha , Contreras María José , Ortuño Duniel , Lam Marusella , García Patricia 
Published: September 2020

Abstract
Background: The main goal of antimicrobials is to eliminate microorganisms that persists despite mechanical treatment. This is the case of Porphyromonas gingivalis (Pg), frequently isolated in patients with periodontitis. Global antibiotic studies evaluated in randomized clinical trials and in vitro studies have shown mixed results regarding effectiveness and susceptibility, even with different protocols where it is not clear if the laboratory test applied can affect the results. This information is relevant in order to obtain clinical outcomes and prevent antimicrobial resistance for their over-prescription or inadequate choice. The objective of this study was to describe the antimicrobial susceptibility in vitro of Pg to metronidazole, clindamycin, amoxicillin plus clavulanate, moxifloxacin and azithromycin in periodontal patients by three testing protocols.Methods: Microbiological samples were obtained in patients with a diagnosis of generalized moderate or severe periodontitis. They were incubated in anaerobic conditions for up to 7 days, and those morphologically compatible with Pg were isolated and identified by a mass spectrometer (MALDI-TOF MS). The three most frequently protocols for antimicrobials susceptibility tests (Blood agar- McFarland 0.5- Epsilometer test; Brucella blood agar- McFarland 1.0- Epsilometer test; Brucella blood agar- McFarland 0.5-Agar dilution) were applied to the same strain describing their profile and reporting any difference between the tests. The breakpoints considered the guidelines of CLSI and previous publications.Results: 50 patients (25 women, 25 men) with periodontitis between 34-69 years were selected. Finally, 25 Pg positives strains (50%) were recovered for the susceptibility analysis and all of them were highly sensitive to all antibiotics (range 96%-100%). Only one strain was resistant to azithromycin in one protocol, and no differences were found in the susceptibility results between the three tests.Conclusion: The Pg strains were highly susceptible to the five antibiotics evaluated in this population, showed a high level of susceptibility and significant agreement between the three tests applied, therefore the type of laboratory test used had not impacted on clinical interpretation. These findings are positives in terms of susceptibility and would provide several antibiotics treatment alternatives, and its prescription could be the best choice for the patient's specific context.
Solitaire AB thrombectomy system: immediate results in 17 acute limb ischemia patients
Authors: Zhou Yangyi , Sutedjo Janesya , Gong Maofeng , Kong Jie , Zhao Boxiang , He Xu , Su Haobo 
Published: September 2020

Abstract
Background

Solitaire AB stent was approved for mechanical thrombectomy for acute cerebral infarction.
Objectives

To present our initial experience regarding the efficacy and safety of mechanical thrombectomy using the Solitaire AB device for the treatment of acute limb ischemia (ALI).
Patients and methods

17 consecutive patients presenting with acute limb ischemia underwent endovascular therapy using the Solitaire AB device. Immediate angiographic results and early clinical outcomes are presented.
Results

Technical success was achieved in 15 patients (88.2%).Recanalization of more than IIb on the TILI scale was achieved for 15 patients. Mean times of thrombectomy attempts were 3 times.41.2%(n = 7) had excellent results. 41.2%(n = 7) patients had good results. 2 had fair results, and 1 patient had a poor result. 30days amputation rate was 6%(n = 1).There was no death case.
The Burden of Liver Cirrhosis in Mortality: Results from the Global Burden of Disease Study 2017
Authors: Ye Fei , Zhai Mimi , Long Jianhai , Shu Bo , Liu Chun , Gong Yi , Li Li , Zhang Dan , He Chao , Liu Sushun 
Published: September 2020

Abstract
Background: Liver cirrhosis related death is a serious threat worldwide. Rare study explored the mortality trend of liver cirrhosis caused by specific etiologies. This study aimed to demonstrated the pattern and trend based on GBD data.Methods: The liver cirrhosis mortality data was collected from GBD 2017. The ASR and EAPC were used to estimate the temporal trend of liver cirrhosis mortality by etiologies, regions, SDI and sexes.Results: Globally, mortality cases of liver cirrhosis increased 47.15%. Though the global ASR of liver cirrhosis mortality reminded stable during the period, the temporal trend varied in etiologies. The ASR of liver cirrhosis mortality caused by HCV, alcohol consumption and NASH increased with an EPAC of 0.17 (95% CI 0.14–0.20), 0.20 (95% CI 0.16–0.24), 1.00 (95% CI 0.97–1.04), respectively. A decrease trend of ASR was found in etiologies for HBV and other causes. The increase pattern was heterogeneous worldwide. The most pronounced increase trend was found in middle-high SDI regions and Eastern Europe. In contrary, the most pronounced decrease trend was found in low SDI regions and Western Sub-Saharan Africa.Conclusion: Liver cirrhosis is still a public health problem. The growth trend of liver cirrhosis mortality caused by HCV has been slowed by promoting direct-acting antiviral therapy. Unfortunately, we observed an unfavorable trend in etiologies for alcohol consumption and NASH, suggesting that more targeted and specific strategies should be established to limit alcohol consumption and promote healthy lifestyles in high risk countries, especially in middle-high SDI regions and Eastern Europe.
GM-CSF signaling is critical for HER2+ breast leptomeningeal carcinomatosis
Authors: Ansari Khairul , Bhan Arunoday , Chen Mike , Jandial Rahul 
Published: September 2020

Abstract
Leptomeningeal carcinomatosis (LC), when tumor cells spread to leptomeninges surrounding the brain and spinal cord. HER2+ breast cancer is the most common origin of LC. HER2+ LC remains incurable, with few treatment options and response rates of <20%. One major limitation in development of HER2+ LC therapies has been lack of clinically relevant HER2+ LC primary cell-lines and animal models. To address this, we generated cell lines and patient-derived xenograft models using nodular HER2+ LC. This led to identification of granulocyte-macrophage colony-stimulating factor (GM-CSF) as an oncogenic autocrine driver of HER2+ LC. We observed that oligodendrocyte progenitor cells (OPCs) inhibit growth of HER2+ LC in vitro and in vivo. Furthermore, OPC-derived factor TPP1 degrades GM-CSF, decreasing GM-CSF signaling and suppressing HER2+ LC growth. Lastly, we determined that synergistic inactivation of GM-CSF signaling via the intrathecal delivery neutralizing anti-GM-CSF antibodies and a pan-Aurora kinase inhibitor (CCT137690) antagonizes development of HER2+ LC in vivo.
Evaluation of the Efficacy of Methylprednisolone Pulse Therapy in Treatment of Covid-19 Adult Patients with Severe Respiratory Failure: Randomized, Clinical Trial
Authors: Farahani Ramin Hamidi , Mosaed Reza , Nezami-Asl Amir , chamanara Mohsen , Soleiman-Meigooni Saeed , Kalantar Shahab , zoshk Mojtaba Yousefi , Malekabad Ebad Shiri , Hazrati Ebrahim 
Published: September 2020

Abstract
Background: Covid-19 is now global concern and widely spread to the world due to high mortality among the nations we tried to evaluate the efficacy of methylprednisolone pulse in COVID-19 patients with severe respiratory failure.Methods: This study was phase2, double-blind, randomized, clinical trial in adults with COVID-19 (aged ≥18 years old) admitted to the intensive care unit (ICU) of *. Patients with intermediate or severe COVID-19 with PaO2/FiO2 less than 300 and progressive disease unresponsive to standard treatments admitted to ICU. Patients were randomly allocated in either control or investigation group. The control group received recommended regimen for COVID-19. The investigation group received the recommended regimen plus Methylprednisolone (1000mg/day for three days) and oral prednisolone 1mg/kg with tapering of dose within ten days. Results: A total of 29 ICU patients with intermediate or severe COVID-19 pneumonia recruited in this study. Fourteen patients (4 female, ten male) allocated in the investigation group, and 15 patients (6 female, nine male) assigned to the control group. The participant’s average age was 64.03±13.545 (case: 61.07±12.83, control: 66.80±14.03). The patients with methylprednisolone pulse had significantly higher systolic (P=0.018) and diastolic (P=0.001) blood pressure, meanwhile, the Glasgow coma scale (GCS) of methylprednisolone group was considerably (P<0.001) higher, and by the improvement in SpO2 of methylprednisolone group none of these patients needed mechanical ventilation.Conclusion: This study demonstrated methylprednisolone pulse in COVID-19 severe respiratory failure dramatically improves the clinical condition of patients including, GCS, and SpO2 of patients.Clinical Trial Registration Number: IRCT20200406046963N1
Do Laboratory Biomarkers Predict Survival in Severe COVID-19? A Cross-sectional Study
Authors: Bahadur Sher , Rahim Fawad , Amin Said , Noor Mohammad , Mahmood Afsheen , Gul Huma , Usman Muhammad , Khan Muhammad Asif , Ullah Raza , Shahab Khalid , Haq Anwar Ul 
Published: September 2020

Abstract
BackgroundAvailable research compared serum biomarkers such as lymphocyte count, C-reactive protein, ferritin, Lactate Dehydrogenase and D-dimers to predict survival in patients with mild, moderate and severe COVID-19. This study aims to compare these biomarkers among survivors and non-survivors of severe COVID-19. MethodsThis was a cross-sectional study based on patient’s data retrieved from Hospital Information System. Sixty-nine patients for whom a record of the biomarkers and survival status was available, were included in the study. For every patient, baseline and peak values were selected for CRP level, serum ferritin level, serum LDH level and serum D-Dimer level. Similarly, baseline and trough levels were selected for lymphocytes. Data were analyzed using SPSS version 21. Mean and standard deviation was used to compare the biomarkers with paired t-test. P value less than 0.05 was taken as significant. ResultsThe mean age of the study population was 55.5±9.1 years and 72.5% were male. Among survivors, the increase in CRP level was not significant (from 15.80±9.8 mg/dl to 17.87 ±8.4 mg/dl, p=0.45) while among the non-survivor, the increase in CRP level was significant (from 16.68± 10.90 mg/dl to 20.77±12.69 mg/dl, p=0.04). There was no significant rise in serum LDH levels in survivors (from 829.59±499 U/L to 1018.6±468 U/L, p=0.20) while there was a statistically significant increase in serum LDH level in non-survivors (from 816.2±443.08 U/L to 1056.61±480.54 U/L, p=0.003). Lymphocyte count decreased significantly in both survivors (p=0.001) and non-survivors (p=0.001). There was no statistically significant elevation in serum ferritin among the survivors and non-survivors (p > 0.05). The D-Dimer level increased significantly in both survivors (p=0.01) and non-survivors (p=0.001).Conclusions In severe COVID-19 patients, serum CRP and LDH can be used for risk stratification and predicting survival. Lymphopenia, increase in serum ferritin and D-dimers may not predict survival.Trial Registration Not applicable
On investigations of the observed thermal anomaly in earthquake precursors: A case study from the 1993 Latur earthquake prone area in western India
Authors: Dimri Vijay P , Padhy Simanchal , Mondal N C , Reddy G K , Ramacharyulu G G. , Singh V S , Sokamble S R , Shanker C 
Published: September 2020

Abstract
We report and discuss monitoring of short-term variations of widely used multi-geophysical parameters in Latur-Killari area in western India, the region that faced a major devastating earthquake in 1993. An abnormal rise in atmospheric temperature of more than 20 ° C at 11200 m height was observed in the air-flight just 100 km away from Latur during a monsoon period. To investigate the causes of such temperature rise, we studied seismicity of the area in relation to the 1993 Latur event, and continuously monitored ground-water level and soil Helium gas for one week immediately following this observation under a precursory ‘quick please’ operation in the study area. There are no precursory seismic signals associated with this temperature rise; hence the operation was suspended after one week time. Although this thermal anomaly is not followed by any major earthquake over the area, it has larger implications in atmosphere research area. While a detailed investigation of such anomaly is beyond the scope this paper, we report here the possibility that the satellite thermal sensor cannot penetrate thick clouds to accurately retrieve the temperature. We are cautious of arriving at a firm conclusion, but the findings of this study certainly call for continuous monitoring of temperature over the earthquake prone areas to gain insight into the physics of short-lived variation in temperature over spatially limited extent, especially over the earthquake prone areas for improved seismic hazard assessment.
Labor efficiency, government spending and productivity nexus based on panel ARDL approach: Evidence from selected European countries
Authors: Xuezhou Wen , Hussain Rana Yassir , Hussain Haroon , Saad Muhammad , Qalati Sikandar Ali , Ali Shaibu 
Published: September 2020

Abstract
The current study advocates the role of efficient labor, average gross earnings per person, government spending, and quality of human life in defining the productivity of thirteen European countries. This study applied panel ARDL approach for data period ranging from 2001 to 2016. The results, in the long run, suggested that more efficient labor, increased gross earnings, and higher HDI causes higher productivity in the selected European countries. However, the results for the gross earnings were positive but insignificant. Government spending and inflation had a significant negative impact on productivity. These results suggest to keep inflation in check and limit the government expenditure to human development and to the productive uses in the selected countries.
Comparing of the reduction accuracy of marker-3D measurement method and traditional radiograph measurement method in the treatment of patients with tibia fracture treated with Taylor Spatial Frame: a retrospective study
Authors: Liu QiXin , Li Hong , Liu SiDa , Fu XueFei , Liu YanShi , Zhang XingPeng , Zhang JinLi , Weng NengYuan , Zhang Tao 
Published: September 2020

Abstract
Background

The Taylor Spatial Frame (TSF) has been widely used on tibia fractures. However, traditional radiograph measurement method is complicated and the reduction accuracy is not high enough for correcting residual deformities. We proposed the marker-3D measurement method to solve these problems. This study aimed to compare the reduction accuracy of the traditional radiograph measurement method and the marker-3D measurement method in tibia fracture treated with TSF.
Methods

From January 2016 to June 2019, A retrospective analysis was performed based on the patients with tibia fracture treated with TSF in Tianjin Hospital. Forty-one patients were qualified for this study, including 21 patients in the marker-3D measurement group (experimental group) and 20 patients in the traditional radiograph measurement group (control group). In the experimental group, CT scan was performed for 3D reconstruction with 6 markers installed on the TSF, to determine the adjusting plan; in the control group, the Anteroposterior (AP) and Lateral radiographs were performed for the deformity parameters. All fractures were corrected after TSF adjusting, and then X-rays were taken to measure the residual deformities.
Results

All patients reached functional reduction. The residual displacement deformity (RDD) in AP radiograph was 0.5 (0, 1.72) mm in experimental group and 1.74 (0.43, 3.67) mm in control group; the residual angle deformity (RAD) in AP radiograph was 0 (0, 1.25) ° in experimental group and 1.25 (0.62, 1.95) °in control group. As to the Lateral radiograph, the RDD was 0 (0, 1.22) mm in experimental group and 2.02 (0, 3.74) mm in control group; the RAD was 0 (0, 0) ° in experimental group and 1.42 (0, 1.93) ° in control group. Significant differences in all above comparisons were found between the groups (AP radiograph RDD: P = 0.024, RAD: P = 0.020; Lateral radiograph RDD: P = 0.016, RAD: P = 0.004).
Conclusion

Both groups achieved satisfactory fracture reduction. However, the residual deformities in the experimental group were significantly smaller. This study proved that the marker-3D measurement method could further improve the accuracy of the reduction.
Sex-Specific Impact of Diabetes Mellitus on Left Ventricular Systolic Function and Prognosis in Heart Failure
Authors: Kwak Soongu , Hwang In-Chang , Park Jin Joo , Park Jae-Hyeong , Park Jun-Bean , Cho Goo-Yeong 
Published: September 2020

Abstract
Background: Diabetes mellitus (DM) aggravates the clinical features and outcomes of heart failure (HF). However, the sex-specific cardiovascular consequence of DM in HF patients remains unclear. We aimed to investigate the sex differences in associations of DM with echocardiographic phenotypes and clinical outcomes of HF.Methods: We studied 4,180 patients admitted for acute HF between 2009 and 2016 (median follow-up, 31.7 months), whose left ventricular global longitudinal strain (LV-GLS) data were available. Patients were compared by sex and DM. Structural equation model (SEM) analysis was performed to evaluate the moderating effects of two causal paths, via ischemic heart disease (IHD) and LV-GLS, linking DM with mortality by sex. Results: Among 1,431 patients with HF and DM (34.2%), women had more preserved LV systolic function, whereas men had more ischemic etiology. Compared to non-diabetic women, diabetic women had lower LV-GLS (11.3% versus 10.1%, p<0.001), but the difference was attenuated within men (9.7% versus 9.2%, p=0.014). In Cox analyses, DM was an independent predictor for higher mortality in both women and men, with a statistically insignificant but higher relative risk in women than men (adjusted hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.15-1.59 for women versus HR 1.24, 95% CI 1.07-1.44 for men, p for interaction=0.669). Restricted cubic spline curves showed that LV-GLS consistently declined, and mortality increased in women as hyperglycemia became more severe, but these trends were not evident in men. In SEM analysis, the main driver from DM to mortality differed by sex; men had a stronger effect via IHD than LV-GLS, whereas effect mediating LV-GLS was the only predominant path in women.Conclusions: DM increases the mortality risk in HF irrespective of sex. However, the main driver leading to mortality differed by sex, suggesting the importance of sex-specific strategies for HF management.