bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental Migration and Early Childhood Development in Rural China
Authors: Yue Ai , Bai Yu , Shi Yaojiang , Luo Renfu , Rozelle Scott , Medina Alexis , Sylvia Sean 
Published: March 2020

AbstractNearly one-quarter of all children under age 2 in China are left behind in the countryside as parents migrate to urban areas for work. We use a four-wave longitudinal survey following young children from 6 to 30 months of age to provide first evidence on the effects of parental migration on development, health, and nutritional outcomes in the critical first stages of life. We find that maternal migration has a negative effect on cognitive development: migration before children reach 12 months of age reduces cognitive development by 0.3 standard deviations at age 2. Possible mechanisms include reduced dietary diversity and engagement in stimulating activities, both known to be causally associated with skill development in early life. We find no effects on other dimensions of physical and social-emotional health.
Natural Hazards, Disasters, and Demographic Change: The Case of Severe Tornadoes in the United States, 1980–2010
Authors: Raker Ethan J. 
Published: March 2020

AbstractNatural hazards and disasters distress populations and inflict damage on the built environment, but existing studies yielded mixed results regarding their lasting demographic implications. I leverage variation across three decades of block group exposure to an exogenous and acute natural hazard—severe tornadoes—to focus conceptually on social vulnerability and to empirically assess local net demographic change. Using matching techniques and a difference-in-difference estimator, I find that severe tornadoes result in no net change in local population size but lead to compositional changes, whereby affected neighborhoods become more White and socioeconomically advantaged. Moderation models show that the effects are exacerbated for wealthier communities and that a federal disaster declaration does not mitigate the effects. I interpret the empirical findings as evidence of a displacement process by which economically disadvantaged residents are forcibly mobile, and economically advantaged and White locals rebuild rather than relocate. To make sense of demographic change after natural hazards, I advance an unequal replacement of social vulnerability framework that considers hazard attributes, geographic scale, and impacted local context. I conclude that the natural environment is consequential for the sociospatial organization of communities and that a disaster declaration has little impact on mitigating this driver of neighborhood inequality.
A Computational Approach for Modeling the Allele Frequency Spectrum of Populations with Arbitrarily Varying Size
Authors: Chen Hua 
Published: March 2020

Abstract
The allele frequency spectrum (AFS), or site frequency spectrum, is commonly used to summarize the genomic polymorphism pattern of a sample, which is informative for inferring population history and detecting natural selection. In 2013, Chen and Chen developed a method for analytically deriving the AFS for populations with temporally varying size through the coalescence time-scaling function. However, their approach is only applicable to population history scenarios in which the analytical form of the time-scaling function is tractable. In this paper, we propose a computational approach to extend the method to populations with arbitrary complex varying size by numerically approximating the time-scaling function. We demonstrate the performance of the approach by constructing the AFS for two population history scenarios: the logistic growth model and the Gompertz growth model, for which the AFS are unavailable with existing approaches. Software for implementing the algorithm can be downloaded at http://chenlab.big.ac.cn/software/.
Estimates of healthcare utilisation and deaths from waterborne pathogen exposure in Ontario, Canada
Authors: Greco Susan Lavinia , Drudge Christopher , Fernandes Reisha , Kim JinHee , Copes Ray 
Published: March 2020

Abstract
Burden of disease analyses can quantify the relative impact of different exposures on population health outcomes. Gastroenteritis where the causative pathogen was not determined and respiratory illness resulting from exposure to opportunistic pathogens transmitted by water aerosols have not always been considered in waterborne burden of disease estimates. We estimated the disease burden attributable to nine enteric pathogens, unspecified pathogens leading to gastroenteritis, and three opportunistic pathogens leading primarily to respiratory illness, in Ontario, Canada (population ~14 million). Employing a burden of disease framework, we attributed a fraction of annual (year 2016) emergency department (ED) visits, hospitalisations and deaths to waterborne transmission. Attributable fractions were developed from the literature and clinical input, and unattributed disease counts were obtained using administrative data. Our Monte Carlo simulation reflected uncertainty in the inputs. The estimated mean annual attributable rates for waterborne diseases were (per 100 000 population): 69 ED visits, 12 hospitalisations and 0.52 deaths. The corresponding 5th–95th percentile estimates were (per 100 000 population): 13–158 ED visits, 5–22 hospitalisations and 0.29–0.83 deaths. The burden of disease due to unspecified pathogens dominated these rates: 99% for ED visits, 63% for hospitalisations and 40% for deaths. However, when a causative pathogen was specified, the majority of hospitalisations (83%) and deaths (97%) resulted from exposure to the opportunistic pathogens Legionella spp., non-tuberculous mycobacteria and Pseudomonas spp. The waterborne disease burden in Ontario indicates the importance of gastroenteritis not traced back to a particular pathogen and of opportunistic pathogens transmitted primarily through contact with water aerosols.
The Duality of Reforestation Impacts on Surface and Air Temperature
Authors: Novick Kimberly A. , Katul Gabriel G. 
Published: March 2020

AbstractEvidence is mounting that temperate‐zone reforestation cools surface temperature (Tsurf), mitigating deleterious effects of climate warming. While Tsurf drives many biophysical processes, air temperature (Ta) is an equally important target for climate mitigation and adaptation. Whether reductions in Tsurf translate to reductions in Ta remains complex, fraught by several nonlinear and intertwined processes. In particular, forest canopy structure strongly affects near‐surface temperature gradients, complicating cross‐site comparison. Here the influence of reforestation on Ta is assessed by targeting temperature metrics that are less sensitive to local canopy effects. Specifically, we consider the aerodynamic temperature (Taero), estimated using a novel procedure that does not rely on the assumptions of Monin‐Obukhov similarity theory, as well as the extrapolated temperature into the surface layer (Textrap). The approach is tested with flux tower data from a grass field, pine plantation, and mature hardwood stand co‐located in the Duke Forest (North Carolina, USA). During growing season daytime periods, Tsurf is 4–6 °C cooler, and Taero and near‐surface Textrap are 2–3 °C cooler, in the forests relative to the grassland. During the dormant season, daytime differences are smaller but still substantial. At night, differences in Taero are small, and near‐surface Textrap is warmer over forests than grasslands during the growing season (by 0.5 to 1 °C). Finally, the influence of land cover on Textrap at the interface between the surface and mixed layer is small. Overall, reforestation appears to provide a meaningful opportunity for adaption to warmer daytime Ta in the southeastern United States, especially during the growing season.
A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer
Authors: Longo Joseph , Hamilton Robert J. , Masoomian Mehdi , Khurram Najia , Branchard Emily , Mullen Peter J. , Elbaz Mohamad , Hersey Karen , Chadwick Dianne , Ghai Sangeet , Andrews David W. , Chen Eric X. , van der Kwast Theodorus H. , Fleshner Neil E. , Penn Linda Z. 
Published: March 2020

Abstract
Background
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. Epidemiological and pre-clinical evidence support an association between statin use and delayed prostate cancer (PCa) progression. Here, we evaluated the effects of neoadjuvant fluvastatin treatment on markers of cell proliferation and apoptosis in men with localized PCa.

Methods
Thirty-three men were treated daily with 80 mg fluvastatin for 4–12 weeks in a single-arm window-of-opportunity study between diagnosis of localized PCa and radical prostatectomy (RP) (ClinicalTrials.gov: NCT01992042). Percent Ki67 and cleaved Caspase-3 (CC3)-positive cells in tumor tissues were evaluated in 23 patients by immunohistochemistry before and after treatment. Serum and intraprostatic fluvastatin concentrations were quantified by liquid chromatography-mass spectrometry.

Results
Baseline characteristics included a median prostate-specific antigen (PSA) level of 6.48 ng/mL (IQR: 4.21–10.33). The median duration of fluvastatin treatment was 49 days (range: 27–102). Median serum low-density lipoprotein levels decreased by 35% after treatment, indicating patient compliance. Median PSA decreased by 12%, but this was not statistically significant in our small cohort. The mean fluvastatin concentration measured in the serum was 0.2 μM (range: 0.0–1.1 μM), and in prostatic tissue was 8.5 nM (range: 0.0–77.0 nM). At these concentrations, fluvastatin induced PCa cell death in vitro in a dose- and time-dependent manner. In patients, fluvastatin treatment did not significantly alter intratumoral Ki67 positivity; however, a median 2.7-fold increase in CC3 positivity (95% CI: 1.9–5.0, p = 0.007) was observed in post-fluvastatin RP tissues compared with matched pre-treatment biopsy controls. In a subset analysis, this increase in CC3 was more pronounced in men on fluvastatin for >50 days.

Conclusions
Fluvastatin prior to RP achieves measurable drug concentrations in prostatic tissue and is associated with promising effects on tumor cell apoptosis. These data warrant further investigation into the anti-neoplastic effects of statins in prostate tissue.
FKBP5 haplotypes and PTSD modulate the resting-state brain activity in Han Chinese adults who lost their only child
Authors: Qi Rongfeng , Luo Yifeng , Zhang Li , Weng Yifei , Surento Wesley , Jahanshad Neda , Xu Qiang , Yin Yan , Li Lingjiang , Cao Zhihong , Thompson Paul M. , Lu Guang Ming 
Published: March 2020

AbstractThe stress-related gene FKBP5 has been related to dysregulated glucocorticoid receptor (GR) signaling, showing increased GR sensitivity in trauma-exposed subjects with post-traumatic stress disorder (PTSD) but not in those without PTSD. However, the neural mechanism underlying the effects of FKBP5 remains poorly understood. Two hundred and thirty-seven Han Chinese adults who had lost their only child were included. Four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080) were genotyped. All 179 participants were successfully divided into three FKBP5 diplotype subgroups according to two major FKBP5 H1 and H2 yin yang haplotypes. Brain average spectral power was compared using a two-way (PTSD diagnosis and FKBP5 diplotypes) analysis of covariance within four separate frequency bands (slow-5, slow-4, slow-3, and slow-2). Adults with PTSD showed lower spectral power in bilateral parietal lobules in slow-4 and in left inferior frontal gyrus (IFG) in slow-5. There was significant FKBP5 diplotype main effect in anterior cingulate cortex (ACC) in slow-4 (H1/H1 higher than other two subgroups), and in precentral/postcentral gyri and middle cingulate cortex (MCC) in slow-3 (H2/H2 higher than other two subgroups). Also, there was a significant diagnosis × FKBP5 diplotype interaction effect in right parietal lobule in slow-3. These findings suggest that adults with PTSD have lower low-frequency power in executive control network regions. Lower power in ACC and greater power in the motor/sensory areas in FKBP5 high-risk diplotype group suggest a disturbance of emotional processing and hypervigilance/sensitization to threatening stimuli. The interaction effect of diagnosis × FKBP5 in parietal lobule may contribute to PTSD development.
Tunable phonon-induced steady-state coherence in a double-quantum-dot charge qubit
Authors: Purkayastha Archak , Guarnieri Giacomo , Mitchison Mark T. , Filip Radim , Goold John 
Published: March 2020

AbstractCharge qubits can be created and manipulated in solid-state double-quantum-dot (DQD) platforms. Typically, these systems are strongly affected by quantum noise stemming from coupling to substrate phonons. This is usually assumed to lead to decoherence towards steady states that are diagonal in the energy eigenbasis. In this article, we show, to the contrary, that due to the presence of phonons the equilibrium steady state of the DQD charge qubit spontaneously exhibits coherence in the energy eigenbasis with high purity. The magnitude and phase of the coherence can be controlled by tuning the Hamiltonian parameters of the qubit. The coherence is also robust to the presence of fermionic leads. In addition, we show that this steady-state coherence can be used to drive an auxiliary cavity mode coupled to the DQD.
Approximate quantum Fourier transform with O(n log(n)) T gates
Authors: Nam Yunseong , Su Yuan , Maslov Dmitri 
Published: March 2020

AbstractThe ability to implement the Quantum Fourier Transform (QFT) efficiently on a quantum computer facilitates the advantages offered by a variety of fundamental quantum algorithms, such as those for integer factoring, computing discrete logarithm over Abelian groups, solving systems of linear equations, and phase estimation, to name a few. The standard fault-tolerant implementation of an n-qubit unitary QFT approximates the desired transformation by removing small-angle controlled rotations and synthesizing the remaining ones into Clifford+T gates, incurring the T-count complexity of $$O(n\,{\mathrm{log}}^{2}\,(n))$$

O

(

n

log

2

(

n

)

)

. In this paper, we show how to obtain approximate QFT with the T-count of $$O(n\,{\mathrm{log}}\,(n))$$

O

(

n

log

(

n

)

)

. For brevity, the above figures omit the dependence on the approximation error ε, assuming the error is fixed. Our approach relies on quantum circuits with measurements and feedforward, and on reusing a special quantum state that induces the phase gradient transformation. We report asymptotic analysis as well as concrete circuits, demonstrating significant advantages in both theory and practice.
Nonlocal Coulomb interaction and spin-freezing crossover as a route to valence-skipping charge order
Authors: Ryee Siheon , Sémon Patrick , Han Myung Joon , Choi Sangkook 
Published: March 2020

AbstractMultiorbital systems away from global half-filling host intriguing physical properties promoted by Hund’s coupling. Despite increasing awareness of this regime dubbed Hund’s metal, effect of nonlocal interaction is still elusive. Here we study a three-orbital model with 1/3 filling (two electrons per site) including the intersite Coulomb interaction (V). Using the GW plus extended dynamical mean-field theory, the valence-skipping charge order transition is shown to be driven by V. Most interestingly, the instability to this transition is significantly enhanced in the spin-freezing crossover regime, thereby lowering the critical V to the formation of charge order. This behavior is found to be closely related to the population profile of the atomic multiplet states in the spin-freezing regime. In this regime, maximum spin states are dominant in each total charge subspace with substantial amount of one- and three-electron occupations, which leads to almost equal population of one- and the maximum spin three-electron state. Our finding unveils another feature of the Hund’s metal and has potential implications for the broad range of multiorbital systems as well as the recently discovered charge order in iron pnictides.
Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study
Authors: Pleguezuelos Olga , James Emma , Fernandez Ana , Lopes Victor , Rosas Luz Angela , Cervantes-Medina Adriana , Cleath Jason , Edwards Kristina , Neitzey Dana , Gu Wenjuan , Hunsberger Sally , Taubenberger Jeffery K. , Stoloff Gregory , Memoli Matthew J. 
Published: March 2020

AbstractFLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, phase IIb efficacy and safety trial was conducted. One hundred and fifty-three healthy individuals 18–55 years of age were randomized to receive one or two doses of adjuvanted FLU-v or adjuvanted placebo subcutaneously on days −43 and −22, prior to intranasal challenge on day 0 with the A/California/04/2009/H1N1 human influenza A challenge virus. The primary objective of the study was to identify a reduction in mild to moderate influenza disease (MMID) defined as the presence of viral shedding and clinical influenza symptoms. Single-dose adjuvanted FLU-v recipients (n = 40) were significantly less likely to develop MMID after challenge vs placebo (n = 42) (32.5% vs 54.8%p = 0.035). FLU-v should continue to be evaluated and cellular immunity explored further as a possible important correlate of protection against influenza.
Benefits of organic manure combined with biochar amendments to cotton root growth and yield under continuous cropping systems in Xinjiang, China
Authors: Zhang Zhiyong , Dong Xiuxiu , Wang Shaoming , Pu Xiaozhen 
Published: March 2020

AbstractOrganic manure and biochar amendments have been used in agriculture to improve soil fertility and enhance crop productivity. Plant roots play an important role in the functionality of individual plants, and although the addition of organic manure and biochar reportedly affect roots, it remains unclear how root morphology and physiology respond. We conducted a field experiment to test the hypothesis that organic manure combined with biochar amendment could also enhance the productivity of continuous cropping systems in Xinjiang cotton plantations. Different levels of organic manure and biochar were applied. Organic manure and biochar significantly affected root morphology and physiology by improving soil nutrients. In the absence of biochar, organic manure amendment increased Root TTC reducing capacity, glutamine synthetase and nitrate reductase activity. Furthermore, morphological and physiological parameters peaked with 6% organic manure combined with 1% biochar. A significant increase in root physiology was recognized with an increase in soil nutrient content at the bud stage and a negative relationship between root physiology and soil total K content at the harvesting stage. Thus, our results indicate that organic manure combined with biochar positively influenced cotton roots, and therefore should be used to improve root health in continuous cropping systems.
The hazardous 2017–2019 surge and river damming by Shispare Glacier, Karakoram
Authors: Bhambri Rakesh , Watson C. Scott , Hewitt Kenneth , Haritashya Umesh K. , Kargel Jeffrey S. , Pratap Shahi Arjun , Chand Pritam , Kumar Amit , Verma Akshaya , Govil Himanshu 
Published: March 2020

AbstractIn 2017–2019 a surge of Shispare Glacier, a former tributary of the once larger Hasanabad Glacier (Hunza region), dammed the proglacial river of Muchuhar Glacier, which formed an ice-dammed lake and generated a small Glacial Lake Outburst Flood (GLOF). Surge movement produced the highest recorded Karakoram glacier surface flow rate using feature tracking (~18 ± 0.5 m d−1) and resulted in a glacier frontal advance of 1495 ± 47 m. The surge speed was less than reports of earlier Hasanabad advances during 1892/93 (9.3 km) and 1903 (9.7 km). Surges also occurred in 1973 and 2000–2001. Recent surges and lake evolution are examined using feature tracking in satellite images (1990–2019), DEM differencing (1973–2019), and thermal satellite data (2000–2019). The recent active phase of Shispare surge began in April 2018, showed two surface flow maxima in June 2018 and May 2019, and terminated following a GLOF on 22–23 June 2019. The surge likely had hydrological controls influenced in winter by compromised subglacial flow and low meltwater production. It terminated during summer probably because increased meltwater restored efficient channelized flow. We also identify considerable heterogeneity of movement, including spring/summer accelerations.
Association between cystatin C gene polymorphism and the prevalence of white matter lesion in elderly healthy subjects
Authors: Maniwa Kyohei , Yano Shozo , Sheikh Abdullah Md. , Onoda Keiichi , Mitaki Shingo , Isomura Minoru , Mishima Seiji , Yamaguchi Shuhei , Nabika Toru , Nagai Atsushi 
Published: March 2020

AbstractCystatin C (CST3) is a cysteine protease inhibitor abundant in the central nervous system, and demonstrated to have roles in several pathophysiological processes including vascular remodeling and inflammation. Previously, we showed a relation of CST3 gene polymorphisms with deep and subcortical white matter hyperintensity (DSWMH) in a small case-control study. In this study, we aimed to investigate the relation in a larger cross-sectional study. Participants of a brain health examination program were recruited (n = 1795) in the study, who underwent routine blood tests and cognitive function tests. Cerebral white matter changes were analyzed by MRI. Additionally, 7 single nucleotide polymorphisms (SNPs) (−82G/C, −78T/G, −5G/A, +4A/C, +87C/T, +148G/A and +213G/A) in the promoter and coding regions of CST3 gene were examined. Among them, carriers of the minor allele haplotype −82C/+4C/+148A were significantly associated with decreased CST3 concentration in the plasma. Unadjusted analysis did not show significant relation between carriers of the minor allele haplotype and periventricular hyperintensity (PVH), but DSWMH was marginally (p < 0.054) increased in this group. After adjusting the effects of other variables like age and kidney function, logistic regression analysis revealed that carriers of the minor allele haplotype were at a significantly increased risk of developing both PVH and DSWMH. Thus, our results suggest that carriers of the minor allele haplotype −82C/+4C/+148A of CST3 gene could be at an increased risk to develop cerebral white matter disturbance.
Local inhomogeneous state in multiferroic SmCrO3
Authors: Oliveira G. N. P. , Teixeira R. C. , Moreira R. P. , Correia J. G. , Araújo J. P. , Lopes A. M. L. 
Published: March 2020

AbstractRare-earth orthochromites with distorted perovskite structure (e.g. RCrO3, R = Sm, Gd) have been under strong debate with respect to the origin of their ferroelectric order. Of particular interest is the question of whether such orthochromites are, in fact, magnetically driven improper ferroelectrics, as many rare-earth manganites or orthoferrites. Here we show, by studying at the atomic scale the rare-earth SmCrO3 system that a distortion of the Sm local environment emerges within the paramagnetic phase, near room temperature. Our Electric Field Gradient measurements combined with first-principles calculations show that the emergent phase cannot be simply ascribed to the Pna21 structure as reported for GdCrO3 or SmCrO3. Instead a local inhomogeneous state, where regular non-polar and polar distorted environments coexist, develops at low temperatures.