bluuebunny/crossref_metadata_2025_split huggingface dataset:
The circulating level of Non-coding RNA for breast cancer diagnosis
Authors: wang miao , gu yao , zhang jie , jia zhaojun , wu huijian 
Published: December 2019

Abstract
Background: Lots of non-coding RNAs expression affected breast cancer progression. However, there were no systemic analysis of non-coding RNAs for breast cancer diagnosis in circulatory system. Herein, we aimed to collect all the evidence to test the potential role of non-coding RNAs as novel biomarker in human breast cancers. Methods: A comprehensive search strategy was used to search relevant literatures in the Web of Science, PubMed, and Embase databases from 2012 to November 2019. The correlation between non-coding RNAs in serum, plasma or blood expression and the diagnostic accuracy of BC markers were analyzed. The methodological quality of each study was assessed using the QUADAS-2. Statistical analysis was used the STATA (version 12.0), Meta-Disc1.4 and Review Manager (version 5.3) software. Results: The present meta-analysis the non-coding RNAs expression data of BC patients and healthy specimens’ bloodfrom 2392 patients in 24 publications (32 studies). The pooled sensitivity, specificity, and AUC values were 0.82, 0.83, and 0.89, respectively. Subgroup analyses showed that the expression of non-coding RNA (miRNA, circRNA, andlncRNA) in circulating (including blood, plasma, and serum) of BC was more prone to be detected in TNM stage and subtype of BC group, with a high value of the sensitivity and AUC. Conclusions: The circulating (including blood, plasma, and serum) level of miRNAs, circRNAs, and lncRNAs for breast cancer diagnosis may be effective, particularly in TNM stage, subtype of BC (ER/PgR, PR or HER2/c-erbB-2) breast cancer. Further prospective studies on the diagnostic value of non-coding RNAs from breast cancer are needed in the future.
Goals and vectors of ensuring economic security of high-tech technologies
Authors: Bank S. V. , Bank O. A. 
Published: December 2019

Economic instability at the global level predetermines one of the primary scientific and practical issues required to be solved-the formation and implementation of the complex of economic security of companies, especially for those who perform the production of high-tech products. Such companies are forced to adapt to the unstable circumstances of socio-political and socio-economic processes, to select rational solutions to the difficulties and ways to reduce the impact of threats on their own functionality. The implementation of measures to provide economic security will provide conditions for both uninterrupted activity and for increasing the efficiency of economic management, and in addition, will help to increase the opportunities in terms of the economy of individual high-tech companies and the economic environment of the state as a whole.
New Methods in the Diagnosis of Prosthetic Joint Infection
Authors: Karbysheva S. , Renz N. , Yermak K. , Cabric S. , Trampuz A. 
Published: December 2019

A timely and accurate diagnosis of periprosthetic joint infection (PJI) is crucial to plan adequate treatment. Purpose of the study. To evaluate the performance of new diagnostic tests for the diagnosis of PJI. Material and Methods. The performance of novel biomarkers in synovial fluid (i.e. D-lactate and alfa-defensin), molecular test (i.e. PCR of synovial fluid and sonication fluid), new methods to dislodge biofilm from implant surface (i.e. MicroDTTect) and sonication of explanted prosthesis were investigated in patients with PJI and aseptic loosening of the prosthesis. Results. D-lactate showed better sensitivity for the diagnosis of PJI compared to leukocyte count (86% and 80%, respectively). The optimal D-lactate cut-off value was calculated at 1.26 mmol/l. The ADLF test showed sensitivity of 84%, 67% and to 54% depending on classification criteria used for the diagnosis of PJI (Musculoskeletal Infection Society (MSIS), The Infectious Diseases Society of America (IDSA) and proposed European Bone and Joint Infection Society (EBJIS) criteria, respectively). Using the proposed EBJIS definition criteria, the sensitivity of the leukocyte count was significantly higher than that of the ADLF test (86% compared with 54%; p0,001), particularly in chronic PJI (81% compared with 44%, respectively; p0,001). The sensitivity of synovial fluid PCR was 60% and herewith comparable with synovial fluid culture (52%, p = 0,239). The sensitivity and specificity of sonication fluid culture were 58% and 100%, which was comparable to sonication fluid PCR 51% and 94%, respectively. DTT-based method showed low sensitivity for diagnosis of PJI (40%) compared to sonication (80%, p0,01). Conclusion. Synovial fluid D-lactate demonstrated good analytical performance and diagnostic value for the diagnosis of PJI. In particular, the high sensitivity for diagnosing infection and rapid availability of the test result make synovial fluid D-lactate suitable as screening test, whereas ADLF had limited sensitivity (54%) but high specificity (95%) and it should therefore not be used for screening, but rather as a confirmatory test for PJI. Multiplex PCR of synovial fluid and sonication fluid has similar sensitivity and specificity compared to synovial fluid culture, having the advantage of rapid availability of results (within 5 hours) and fully automated process. With further improvement of its performance and inclusion of additional primers, multiplex PCR may complement conventional cultures, especially for rapid and accurate diagnosis of low-grade PJI. Culture of samples obtained by sonication of prostheses showed better sensitivity for the microbiologic diagnosis of prosthetic hip and knee infection compared to chemical based dislodgement such as MicroDTTect.
Identification of Drought Tolerant Mutant Lines of TEF [ERAGROSTIS TEF (ZUCC.) TROTTER]
Authors: Blösch Regula , Rindisbacher Abiel , Plaza-Wüthrich Sonia , Röckel Nora , Weichert Annett , Cannarozzi Gina , Tadele Zeruhin 
Published: December 2019

Introduction: Tef [Eragrostis tef (Zucc.) Trotter] is the major food crop in Ethiopia where it is annually cultivated on about 30% of the total area allocated to cereals. The productivity of tef is, however, significantly reduced by drought which can occur at either the early or the late developmental stage of the crop.
Methodology: A total of 10,000 EMS (ethyl methane sulfonate) mutagenized M2 tef populations were screened first for early and second for terminal drought tolerance. The performance of candidate lines was investigated using diverse agronomical and physiological parameters.
Results and discussion: Several promising lines were obtained for both early and terminal drought tolerance. Among these, genotypes with outstanding performance were found for two drought tolerant tef lines targeting early drought tolerance (dtt2 and dtt13) and three terminal drought tolerant lines targeting terminal drought tolerance (tdt9, tdt15 and tdt19).
Conclusions: Candidate lines for both early and terminal drought tolerance will play vital roles in deve- loping drought tolerance in tef improvement.
KEY WORDS: DROUGHT TOLERANCE, ERAGROSTIS TEF, ORPHAN CROP, MOISTURE SCARCITY, TEF
Selecting for Coupling Phase Recombination between Potyvirus Resitance and White Endosperm Colour in Maize Preferred by Farmers in Sub-Saharan Africa (SSA)
Authors: Bulegeya Victoria B. , Jones Mark W. , Muhamba Tryphone G. , Das Biswanath , Thomison Peter R. , Francis David M. , Redinbaugh Margaret. G. 
Published: December 2019

Maize lethal necrosis (MLN) disease caused by a combined infection of Maize chlorotic mottle virus (MCMV) and any cereal infecting potyvirus is a threat to food security in Sub-Saharan Africa (SSA). Resistance to potyvirus has been extensively studied and Mdm1 gene for potyvirus resistance on chromosome 6 of maize is linked to Y1 gene for maize endosperm colour. This study is aimed at se- lecting for coupling-phase recombination of potyvirus resistance and white endosperm colour. White susceptible maize lines CML333 and CML277 were crossed with a yellow resistant line, Pa405, to produce F1 and F2 progenies. Progenies were screened using molecular markers to recover 22 white endosperm recombinants. 22 selections were advanced to F3 recombinant families, and 10 were as- sayed for their responses to Maize dwarf mosaic virus (MDMV) and Sugarcane mosaic virus (SCMV). Four families segregated for SCMV resistance, selection of homozygous recombinants within these families will provide lines appropriate for improving lines with resistance to SCMV and MLN resistance in SSA.
KEY WORDS: MAIZE LETHAL NECROSIS (MLN), WHITE MAIZE, POTYVIRUS RESISTANCE, GENETIC RECOMBINATION, SUB-SAHARAN AFRICA.
The Role and Contribution of Plant Breeding and Plant Biotechnology to Sustainable Agriculture in Africa
Authors: Kyetere D. , Okogbenin E. , Okeno J. , Sanni K. , Munyaradzi J. , Nangayo F. , Kouko E. , Oikeh S. , Abdourhame I. 
Published: December 2019

Africa’s economy is driven by agriculture, a sector that constitutes 32% of the continent’s GDP. The ongoing Agricultural Transformation Agenda (ATA) in Africa hinges on a system change (from subsistence farming to agribusiness) approach that explores high productivity to strengthen the African economy. During the “Green Revolution” period, increased global yields of cereal crops were achieved through the interactions of breeding and agronomy. However, in the face of current challenges, such as climate change and need for new market niches, there is an increasing exigency to explore modern plant breeding (including biotechnology) to develop new varieties with the capacity for high yields in reduced chemical-input systems and with the genetic diversity needed to maintain yield stability in Africa ́s fluctuating climatic conditions. Biotechnology has significantly shortened the time required for the development of new cultivars, varieties and hybrids. Modern breeding tools include Double Haploid technology, marker assisted breeding, genomics, genetic engineering and genome editing. It is these tools that help accelerate the development of market responsive varieties needed for sustainable agriculture in Africa that will be highlighted.
KEY WORDS: TECHNOLOGY, CROP IMPROVEMENT, GENETICS, MODERN BREEDING TOOLS.
Rebekka A. Klein/Dominik Finkelde (Hg.): Souveränität und Subversion
Authors: Agridopoulos Aristotelis 
Published: December 2019

Rezension von Rebekka A.Klein und Dominik Finkelde (Hg.): Souveränität und Subversion. Figurationen des Politisch-Imaginären. Freiburg/München: Alber 2015.
Pengembangan Trainer Indikator Denyut Jantung
Authors: Utami Pipit , Fajar Muklas 
Published: December 2019

Salah satu capaian pembelajaran mata kuliah instrumentasi adalah mampu menjelaskan penggunaan konsep instrumentasi pada penerapan teknologi instrumentasi. Pengembangan media merupakan salah satu upaya mencapai capaian pembelajaran tersebut. Penerapan teknologi instrumentasi yang diangkat dalam penelitian ini adalah penggunaan photodioda sebagai sensor denyut jantung yang memungkinkan penggunaan berbagai macam rangkaian pengkondisi sinyal untuk memodifikasi sinyal ke output. Artikel ini bertujuan untuk mendeskripsikan desain media berdasarkan analisis kebutuhan dan memaparkan hasil evaluasi pengembangan media tersebut. Media dikembangkan dengan tahapan analisis kebutuhan, desain, pengembangan dan evaluasi. Hasil menunjukkan bahwa: (1) media berupa trainer berbentuk kotak yang berisikan titik-titik pengukuran (sensor, pengkondisi sinyal dan output) diatas skema rangkaian sesungguhnya dan jobsheet praktik; dan (2) evaluasi menunjukkan bahwa trainer memiliki unjuk kerja yang sesuai dan mendapat penilaian layak dari mahasiswa. Sebagai tambahan penggunaan trainer tersebut memudahkan mahasiswa dalam memaparkan variabel proses, sensor, pengkondisi sinyal dan output dari media pembelajaran pengukur denyut jantung yang dikembangkan.
Alat Ukur Berat Badan, Tinggi Badan dan Suhu Badan di Posyandu Berbasis Android
Authors: Cahyono Tri Hamdani Agung , Suprayitno Eko Agus 
Published: December 2019

Perkembangan ilmu pengetahuan dan teknologi semakin meningkat terutama di bidang elektronika. Hal tersebut menginspirasi peneliti untuk membuat alat yang bersifat ekonomis dan efisien, sehingga mempunyai fungsi utama yaitu untuk mempermudah suatu pekerjaan kader posyandu. Sistem Alat ukur berat badan, tinggi badan dan suhu badan di posyandu berbasis android merupakan pengembangan dari peneliti sebelumnya yang didukung dengan tampilan data angka yang muncul di android untuk mempermudah kader posyandu dalam melihat atau mengamati data angka pada bayi di posyandu. Perancangan alat terdiri dari arduino uno sebagai pengolah data, sensor load cell (berat), sensor ultrasonik (tinggi) dan sensor ds18b20 (suhu) kemudian data angka hasil pembacaan akan berkomunikasi serial menggunakan bluetooth hc-05 selanjutnya akan ditampilkan pada aplikasi smartphone android dalam bentuk data angka. Dari hasil pengujian dan pengambilan data didapatkan akurasi sensor load cell sebesar 96,1 - 96,5 %, sensor hc-sr04 sebesar 99,74 - 99,8 %, dan sensor ds18b20 sebesar 99,56 - 99,66 %, hal ini menunjukan bahwa ketiga sensor yang digunakan memiliki sistem yang baik dengan akurasinya yang tinggi.
SWOT ANALYSIS AND TOWS MATRIX E-GOVERNMENT ON TANA TIDUNG CITY OF KALIMANTAN UTARA
Authors: Rudy Rudy , Prasetia Abdul Muis 
Published: December 2019

ABSTRAct Information and Communication Technology (ICT) can improve the speed of information delivery, efficiency, global reach and transparency. One of the efforts to realize good corporate governance (GCG) governance in the era of regional autonomy is to use information and communication technology or popularly called e-Government. The implementation of e-Government the need for master plan information technology as a guide in the integration of information technology in Local Government, e-Government implementation is expected to help improve interaction between government, community and business, so as to encourage political and economic development. In this paper presents the determination of e-Government policy strategy using SWOT analysis method which is considered capable to analyze the relationship or interaction between internal elements, namely strengths and weaknesses, as well as against the external elements of opportunities and threats. Keywords: ICT, SWOT, e-Government.
Rancang Bangun Aplikasi Status Gizi Bayi Berbasis Android
Authors: Kurniastuti Ima , Kamil Ahmad Syafiq 
Published: December 2019

Penelitian ini bertujuan untuk menghasilkan Aplikasi Status Gizi Bayi Berbasis Android yang mempermudah petugas kesehatan dalam menentukan status gizi bayi. Proses pembuatan dilakukan menggunakan Android Studio. Fitur dalam Android Studio yang dimanfaatkan adalah fitur TextView, fitur Radiogroup dan fitur Button. Input dalam aplikasi terdiri dari lima macam yaitu usia, berat badan, panjang bayi, lingkar kepala memanfaatkan fitur TextView sedangkan input jenis kelamin menggunakan fitur Radiogroup. Aplikasi memiliki dua tombol yaitu tombol hitung dan tombol reset. Tombol hitung berfungsi untuk memulai proses pemeriksaan dan tombol reset berfungsi untuk menghapus semua input yang dilakukan oleh pengguna sebelumnya sehingga memudahkan pengguna dalam melakukan pemeriksaan status gizi bayi berikutnya. Output dari aplikasi adalah dibawah normal, normal, dan diatas normal sesuai Standar Pengukuran Status Gizi Bayi dari Kementerian Kesehatan RI. Hasil testing aplikasi menunjukkan output sesuai dengan Standar Pengukuran Status Gizi Bayi dari Kementerian Kesehatan RI. Namun untuk pengembangan aplikasi masih perlu dilakukan pengembangan yaitu tampilan yang terlalu sederhana dan aplikasi dapat dilengkapi menu login untuk mengetahui perkembangan bayi secara berkala.
Znaczenie rytuału w paschalnej liturgii rodzinnej w świetle księgi „Sefer habrachot”
Authors: Rucki Mirosław 
Published: December 2019

Artykuł zawiera analizę typowych tekstów liturgii paschalnej pod kątem znaczenia jej rytuałów dla osób uczestniczących w celebracji. Omówione zostały poszczególne czynności i wypowiadane słowa, w kolejności ich występowania, zaczynając od poszukiwania i zniszczenia zakwasu w przeddzień Paschy i kończąc na odliczaniu omeru po jej zakończeniu. Wszystkie błogosławieństwa i narracje wypowiadane w kontekście wykonywanych czynności zawierają czynniki, które sprzyjają umocnieniu więzi rodzinnych. Odprawiana liturgia uobecnia dawne wydarzenia i podkreśla wspólnotowe doświadczenie Boga na przestrzeni pokoleń oraz zależność rodziny i całego narodu żydowskiego od działania Boga.
STRATEGI HUMAS DINAS PARIWISATA KOTA BANDA ACEH DALAM MEMBANGUN BANDA ACEH SEBAGAI KOTA PARIWISATA (Studi Pada Dinas Pariwisata Banda Aceh)
Authors: Azman Zakirah 
Published: December 2019

This research was titled "PR Strategy of tourism Office of Banda Aceh in building Banda Aceh as Tourism city". The theory used is theory of planning. This research is qualitative research with descriptive type. There are 5 informant in this study. The data collection methods used are interviews, observations, and documentation. Based on the research that has been done, the results of the strategy that was conducted in the promotion process of Banda Aceh as a tourism city is ranging from the annual program of Chairming Kota Banda ACEH, doing cooperation with City District government in the vicinity of Banda Aceh, doing cooperation with travel-travel both at the Regional, national and international level, as well as promoting through social media Instagram and also the use of the official website To provide information about tourism in the city of Banda Aceh. Constraints such as the lack of understanding of the community around the location of the tourist objects from the positive value of the location of tourist objects, there are still public statmen to the condition of Banda Aceh resulting from the history of conflict In Aceh.
INTERCULTURAL ASPECTS IN LANGUAGE EDUCATION
Authors: Rokhayati Titi 
Published: December 2019

Intercultural understanding essentiallybecomes a part of living with others in the diverse world of the twenty-first century. It assists people to become responsible local and global citizens through their education for living and working together in an interconnected world. Language is a major component and supporter of culture as well as a primary tool for transferring message, which is inextricably bound with culture. Language is a key component of culture. It is also a primary medium for transmitting the culture itself. Without language, culture would not be possible. Students learning their native language are learning their own culture. Meanwhile, learning a second language also involves learning a second culture to varying degrees. A language is influenced and shaped by culture. It reflects culture. Cultural differences are the most serious areas causing misunderstanding, unpleasantness and even conflict in cross-cultural communication. Both foreign language learners and teachers accordingly should pay more attention to cultural communication information.
THE VIOLATION OF MAXIM RULES IN KETOPRAK HUMOR
Authors: Shofwan Muh Imam 
Published: December 2019

The investigation in fact aimed mainly to analyze the theory of conversational implicature proposed by austin and later on extended by grice’s principle maxim which can be universal and applied to all languages of the world, including java language art show of ketoprak entitled “joko kendil”. The study is expected to be beneficial to the world of literature. In addition, the writer hopes that the result of the study will also give additional information to the reader and contribute to the development of literary study particularly among students who are interested in the literary study. Twenty-three minutes recorded video conversation of all participants of the show data were transcribed into written form and translated into english. Needless to say, the analysis of the data has been based on both austin’s and grice’s principles of pragmatics, conversational implicature theory. Illustrative examples for flouting the four maxims of speech were introduced and analyzed pragmatically. Particularly the research was objected to find out the violation of maxims of quantity, quality, manner and relation flouted and an implicature from each generated. From the analysis, it was found that the claim of “ketoprak” speech can be systematized and it has implicatures in one way but not in another is to some extent true. Thus, this theory can be applied to other java language idiolects.
THE USE OF CUE CARDS FOR TEACHING WRITING OF BIOGRAPHY TEXT
Authors: Maliyatika Ulya , Syafei Muh , Rusiana Rusiana 
Published: December 2019

Students at schools learn to write in order to express their ideas well. They should have a good ability in writingEnglish texts. However, many students find it difficult to express their ideas in a paragraph, and to make a composition correctly. The media factorseems to be one that makes the teaching-learning process unable to achieve its goal. Therefore, the authors propose to apply Cue Cards as teaching media to overcome the problem.The objective of the research is to scrutinize whether there is a significant difference between teaching writing of biography textbefore and that after being taught by using Cue Cards.This experimentemployed one group with pretest and posttest design was conducted at the eleventh grade students of SMA N 1 KaranganyarDemakin academic year 2017/2018 insecond semester. There were 34 students of grade XI IPS 1 taken as the sample through cluster random sampling.The datasetsfor this research were collected through written test. Before cue cards were used in the treatment, the measn score was60. After cue cards were used in some meetings of treatment, the mean score is 82. The hypothesis of the research stated that there is a significant difference between teaching writing of biography text on the eleventh grade students of SMA N 1KaranganyarDemak in academic year 2017/2018) before and after being taught by using cue cardsis confirmed. It can be seen from the calculation of t-test, withdegree offreedom (df) = 33, α = 0,05, t (critical) is ±2.042 and t (obtained) is 8.79. The analysis showed that Ho was denied and Ha was confirmed.Therefore, it is suggested to the English teacherto keep usingcue cardsin teaching writing of biography text.