bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative hormone and transcriptome analyses underline the role of abscisic acid in seed shattering of weedy rice
Authors: Lang Hong , He Yuting , Sun Jian , Li Fengcheng , Ma Dianrong 
Published: April 2020

Abstract
Abstract
Backgrounds: Weedy rice is one of the most severe weeds in paddy fields, strongly characterized by its high seed shattering level. Abscisic acid (ABA) serves as an abscission-accelerating signal and plays a critical role during abscission. However, mechanisms that link ABA and seed shattering remain elusive. In this study, we compared WR04-6 a shattering, and SN9816 non-shattering rice variety for genetic expression and ABA levels in the abscission zone (AZ) and the spikelet.
Results : ABA content in WR04-6, particularly in AZ, was significantly higher than that in SN9816, and it increased remarkably prior to abscission. Transcriptomic analysis and qRT-PCR showed that the expression of NCED , the key gene in ABA biosynthesis, coincided with increased ABA content in AZ and increased significantly during the seed shattering process. Additionally, the expression of genes related biosynthesis and metabolism of IAA, GA, and ETH showed the greatest fold change. Phytohormone levels associated with ABA co-expression-prediction revealed a potential signal transduction network among plant hormones involved in regulating seed abscission.
Conclusions: Altogether, our data strongly indicated that ABA contributes to seed shattering and appears to transiently cooperate with other hormones, triggering a hormone imbalance that leads to the downstream activation of AZ
Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies
Authors: Zhao Junyu , Wen Jing , Wang Shengnan , Yao Jinming , Liao Lin , Dong Jianjun 
Published: April 2020

Abstract
Background: The incidence of thyroid carcinoma is on the rise all the world. Some studies have suggested that the change of adipokines can even induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma.
Methods: Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was performed with sufficiently homogeneous studies. Twenty-nine articles were finally included for analysis.
Results: The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I 2 =98%, P =0.008] and positive rate of tissue’s TNF-α [odds ratios (OR) =11.80, 95% CI: 5.88 to 23.66, I 2 =0%， P <0.00001] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD=1.04, 95% CI: 0.40 to 1.67, I 2 =96%, P =0.001). No significant difference of the positive rate of IL-6 in tissues between carcinoma and control is found (OR=1.23, 95% CI: 0.62 to 2.43, I 2 =86%, P =0.55). The positive ratio of leptin in tissue is significantly associated with the risk of thyroid carcinoma (OR=12.21, 95% CI: 3.36 to 44.40, I 2 =85%, P <0.00001). However, after analyzing three studies on the expression of adiponectin, no significant difference is found in serum adiponectin level between thyroid carcinoma and the control ( P =0.81).
Conclusions: Adipokines play an important role in the occurrence and development of thyroid carcinoma, especially TNF-α, IL-6 and leptin. However, the effect of adiponectin on thyroid carcinoma needs further research.
Bone morphogenetic protein (BMP) receptor inhibitor JL5 synergizes with Ym155 to induce AIF-caspase independent cell death.
Authors: Mondal Arindam , NeMoyer Rachel , Langenfeld Elaine , Glover Danea , Scott Michael , Lairson Lauren , Zloza Andrew , Augeri David , Gilleran John , Peng Youyi , Roberge Jacques , Langenfeld John E. 
Published: April 2020

Abstract
Background: BMP is an evolutionary conserved morphogen that is reactivated in lung carcinomas. BMP receptor inhibitors promote cell death of lung carcinomas by mechanisms not fully elucidated. The studies here reveal novel mechanisms by which the “survivin” inhibitor Ym155 in combination with the BMP inhibitor JL5 synergistically induces death of lung cancer cells.Methods: This study examines the mechanism by which Ym155 in combination with JL5 downregulates BMP signaling and induces cell death of non-small cell lung carcinomas (NSCLC) cell lines. Validation experiments were performed on five passage 0 primary NSCLC.Results: We found that Ym155, which is reported to be a survivin inhibitor, potently inhibits BMP signaling by causing BMPR2 mislocalization into the cytoplasm and its decreased expression. Ym155 mediated cell death is not caused by the inhibition of survivin but involves Ym155 binding to mitochondrial DNA leading to depletion of ATP. The combination of Ym155 and the BMP receptor inhibitor JL5 synergistically causes the downregulation of BMP Smad-1/5 dependent and independent signaling and the induction of cell death of lung cancer cell lines and primary lung tumors. Cell death involves the nuclear translocation of apoptosis inducing factor (AIF) from the mitochondria to the nucleus causing DNA double stranded breaks independent of caspase activation, which occurs only when JL5 and Ym155 are used in combination. Knockdown of BMPR2 together with Ym155 also induced AIF localization to the nucleus.Conclusions: These studies suggest that inhibition of BMPR2 together with Ym155 can induce AIF caspase-independent cell death. AIF caspase-independent cell is an evolutionary conserved cell death pathway that has never been targeted to induce cell death in cancer cells. These studies provide mechanistic insight how to target AIF caspase-independent cell death using BMP inhibitors.
Forecast of streamflows to the Arctic Ocean by a Bayesian neural network model with snowcover and climate inputs
Authors: Rasouli Kabir , Nasri Bouchra R. , Soleymani Armina , Mahmood Taufique H. , Hori Masahiro , Haghighi Ali Torabi 
Published: April 2020

Abstract
Increasing water flowing into the Arctic Ocean affects oceanic freshwater balance, which may lead to the thermohaline circulation collapse and unpredictable climatic conditions if freshwater inputs continue to increase. Despite the crucial role of ocean inflow in the climate system, less is known about its predictability, variability, and connectivity to cryospheric and climatic patterns on different time scales. In this study, multi-scale variation modes were decomposed from observed daily and monthly snowcover and river flows to improve the predictability of Arctic Ocean inflows from the Mackenzie River Basin in Canada. Two multi-linear regression and Bayesian neural network models were used with different combinations of remotely sensed snowcover, in-situ inflow observations, and climatic teleconnection patterns as predictors. The results showed that daily and monthly ocean inflows are associated positively with decadal snowcover fluctuations and negatively with interannual snowcover fluctuations. Interannual snowcover and antecedent flow oscillations have a more important role in describing the variability of ocean inflows than seasonal snowmelt and large-scale climatic teleconnection. Both models forecasted inflows seven months in advance with a Nash–Sutcliffe efficiency score of ≈0.8. The proposed methodology can be used to assess the variability of the freshwater input to northern oceans, affecting thermohaline and atmospheric circulations.
Antidiabetic and Anticholinesterase Properties of Extracts and Pure Metabolites of Fruit Stems of Pistachio (Pistacia vera L.)
Authors: Lawali Yabo Dambagi , Mehmet Akyuz , Tuba Aydin , Ahmet Cakir 
Published: April 2020

:
Five metabolites were isolated by chromatographic methods from the fruit stems
of P. vera and their chemical structures were characterized as masticadienonic acid (1),
tirucallol (2), masticadienolic acid (3), pistachionic acid (4) and inulobiose (5) via FT-IR,
1H-NMR, 13C-NMR, 1D-NMR and 2D-NMR. Pistachionic acid (4), a new shikimic acid
derivative, was isolated from the ethanol extract for the first time. The hexane, chloroform,
ethanol extracts and pure metabolites exhibited antidiabetic properties by inhibiting α-
glycosidase and α-amylase enzymes at different rates. Their inhibitory effects against the α-
glycosidase enzyme were also higher than that of the acarbose (IC50=10.30 mg/mL). Masticadienolic
acid (3) (IC50=0.03 mg/mL), masticadienonic acid (1) (IC50=0.13 mg/mL) and
hexane extract (IC50=0.09 mg/mL) with the lowest IC50 values were found to be most active
substances. Nevertheless, the inhibitory effect of acarbose against the α-amylase enzyme was determined to be
higher than the inhibition effects of the extracts and pure metabolites. According to the IC50 values, the best
inhibitors against the α-amylase were ethanol extract (IC50=5.17 mg/mL), pistachionic acid (4) (IC50=7.35
mg/mL), tirucallol (2) (IC50=7.58 mg/mL) and masticadienolic acid (3) (IC50=8.22 mg/mL), respectively among
the applications. In addition, anticholinesterase properties of the extracts and pure metabolites were investigated
by testing the inhibitory properties against acetylcholine esterase (AChE) and butrylcholine esterase (BChE)
enzymes activities. The results showed that the anticholinesterase properties of all extracts and pure metabolites
were weaker than those of the commercial cholinesterase inhibitors, neostigmine and galantamine, and all applications
reduced the activity of these enzymes at very high concentrations.
Predicting COVID-19 Incidence Through Analysis of Google Trends Data in Iran: Data Mining and Deep Learning Pilot Study
Authors: Ayyoubzadeh Seyed Mohammad , Ayyoubzadeh Seyed Mehdi , Zahedi Hoda , Ahmadi Mahnaz , R Niakan Kalhori Sharareh 
Published: April 2020

Background
The recent global outbreak of coronavirus disease (COVID-19) is affecting many countries worldwide. Iran is one of the top 10 most affected countries. Search engines provide useful data from populations, and these data might be useful to analyze epidemics. Utilizing data mining methods on electronic resources’ data might provide a better insight into the COVID-19 outbreak to manage the health crisis in each country and worldwide.

Objective
This study aimed to predict the incidence of COVID-19 in Iran.

Methods
Data were obtained from the Google Trends website. Linear regression and long short-term memory (LSTM) models were used to estimate the number of positive COVID-19 cases. All models were evaluated using 10-fold cross-validation, and root mean square error (RMSE) was used as the performance metric.

Results
The linear regression model predicted the incidence with an RMSE of 7.562 (SD 6.492). The most effective factors besides previous day incidence included the search frequency of handwashing, hand sanitizer, and antiseptic topics. The RMSE of the LSTM model was 27.187 (SD 20.705).

Conclusions
Data mining algorithms can be employed to predict trends of outbreaks. This prediction might support policymakers and health care managers to plan and allocate health care resources accordingly.
Peer-to-Peer Contact Tracing: Development of a Privacy-Preserving Smartphone App
Authors: Yasaka Tyler M , Lehrich Brandon M , Sahyouni Ronald 
Published: April 2020

Background
The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any intervention or response. Contact tracing using smartphone technology is a powerful tool that may be employed to limit disease transmission during an epidemic or pandemic; yet, contact tracing apps present significant privacy concerns regarding the collection of personal data such as location.

Objective
The aim of this study is to develop an effective contact tracing smartphone app that respects user privacy by not collecting location information or other personal data.

Methods
We propose the use of an anonymized graph of interpersonal interactions to conduct a novel form of contact tracing and have developed a proof-of-concept smartphone app that implements this approach. Additionally, we developed a computer simulation model that demonstrates the impact of our proposal on epidemic or pandemic outbreak trajectories across multiple rates of adoption.

Results
Our proof-of-concept smartphone app allows users to create “checkpoints” for contact tracing, check their risk level based on their past interactions, and anonymously self-report a positive status to their peer network. Our simulation results suggest that higher adoption rates of such an app may result in a better controlled epidemic or pandemic outbreak.

Conclusions
Our proposed smartphone-based contact tracing method presents a novel solution that preserves privacy while demonstrating the potential to suppress an epidemic or pandemic outbreak. This app could potentially be applied to the current COVID-19 pandemic as well as other epidemics or pandemics in the future to achieve a middle ground between drastic isolation measures and unmitigated disease spread.
The role of iron oxidizing bacteria to the quality of leachate on acid sulphate soil
Authors: Napisah Khairatun , Maas Azwar , Hidayah Utami Sri Nuryani , Yusuf Wahida Annisa 
Published: April 2020

The problem encountered in acid sulphate soil is the presence of pyrite (FeS2) which causes soil to have highly acid reaction when the pyrite is oxidized. The decline in quality not only occurs on the soil but also on the quality of the surrounding waters. One way to improve the quality of the leachate is by draining it through biofilter plants in the form of purun tikus (Eleocharis dulcis) and bulu babi (Eleocharis retroflaxa) which can absorb or neutralize these elements. The purpose of this research was to know the inoculant influence of iron oxidizing bacteria to leachate quality in acid sulphate soil. The research was conducted on a pot scale in greenhouse. The research was in randomized block design (RBD) of 3-factors with 3 replications. The first factor was inoculants, the second factor was water management, and the third one was phytoremediation material (Eleocharis dulcis and Eleocharis retroflaxa). The results showed that the plant height in the inoculant treatment+wood charcoal was in the range of 89.33−95.33 cm, while that in the inoculant treatment+husk charcoal was in the range of 89.50­­­−93.00 cm. Meanwhile, the yield of rice with bacteria oxidizing iron inoculant+wood charcoal was higher, which was at 6.77 ton.ha-1 than inoculant treatment of oxidizing iron+husk charcoal which was only 5.95 ton.ha-1.
ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF QUERCUS ILEX LEAVES EXTRACT IN ETHANOL INDUCED LIVER DAMAGE IN WISTAR RATS
Authors: MALIK RENU , SINGHAL K. G. 
Published: April 2020

Objective: This study was undertaken to investigate the hepatoprotective and antioxidant activity of Quercus ilex leaves extract (QILE) on ethanol-induced toxicity in Wistar rats.
Methods: Hepatotoxicity was induced by administering ethanol (40%) at a dose of 7.9 gm/kg/day; p. o. (1:1 of ethanol in olive oil) for 28 d. Silymarin 100 mg/kg/day; p. o. was used as a standard drug. The whole study was divided into a prophylactic and curative study. In the prophylactic study, the Silymarin and QILE (test drug) 100, 200, and 400 mg/kg Body Weight(BW) given orally one hour before administration of 40% ethanol administration for 28 d. In the curative study, 7 d of treatment of Silymarin and QILE 200 and 400 mg/kg BW was given orally after 28 d of ethanol administration to different groups.
Results: Hepatoprotectivity was confirmed by the highly significantly (p<0.001) restoration of elevated biochemical parameters like SGPT, SGOT, ALP, TB, and highly significantly (p<0.001) depleted Albumin and Total protein levels by 200 mg/kg BW QILE in comparison to the positive control group. QILE 200 mg/kg highly significantly (p<0.001) raised the antioxidants by draining the elevated oxidative stress markers in comparison of positive control group. At dose levels QILE 200 mg/kg, significant (p<0.05) protection from loss in body weight and in liver weight was found when the comparison was done with the positive control group. Histopathology revealed that QILE 200 mg/kg reduced the markers of cell necrosis.
Conclusion: Present study revealed that Quercus ilex leaves have antioxidant and hepatoprotective activity due to its chemical constituents.
Teoria crítica, hermenêutica e formação de professores: contribuições de Mario Osorio Marques
Authors: Kuhn Martin , Callai Helena Copetti 
Published: April 2020

Diferentes racionalidades têm perpassado a formação de professores. Expressivamente, em nosso contexto, a tradição acadêmica e a epistemologia da prática. Acusadas de acalentarem a distinção entre teoria e prática assumem um caráter instrumentalizador da formação de professores. Sustentamos que o diálogo proposto por Mario Osorio Marques, teoria crítica e a hermenêutica, se constitui em possibilidade razoável de compreender a educação e a formação dos educadores em tempos que a racionalidade instrumental se agudiza. Marques sugere três exigências à formação dos educadores: a exigência hermenêutica, a exigência crítico-dialética e a exigência epistêmico-instrumental.
The correlation between science process skills and biology cognitive learning outcome of senior high school students
Authors: Ilma Silfia , Al-Muhdhar Mimien Henie Irawati , Rohman Fatchur , Saptasari Murni 
Published: April 2020

Science Process Skills (SPS) are the essential abilities which need to be mastered in learning biology to strengthen students’ learning outcomes. The aim of this study was to analyze the relationship between SPS and biology Cognitive Learning Outcome (CLO) of senior high school students. The sample was 100 tenth graders in Malang. The correlational study used two test types as the instrument (i.e. essay and multiple choice). The essay instrument consisted of 10 items which were developed from SPS aspects (basic and integrated skills). Meanwhile, the biology CLO was measured using multiple choice test which consisted of 30 items. The collected data were analyzed using simple linear regression analysis. The results showed that the highest students’ SPS aspect was observing (78.84%), while the lowest was predicting aspect (27.30%). In addition, the highest achievement of students’ biology CLO was C1 (94.23%), while the lowest was C6 (33.46%). The regression analysis showed that there was a significant correlation between students’ SPS and biology CLO, where the equation was Y = 27.988 + 0.311X. Therefore, it is crucial to consider SPS to be integrated into a learning activity by using various learning models that empowering these skills to improve students’ biology CLO.
Growth performance of Astyanax altiparanae fed with plant and/or animal lipid sources
Authors: Chaves William , Almeida Érica C. , Carneiro Cristiana , Magnone Larisa , Martins Nilton , Bessonart Martin , Zuanon Jener , Salaro Ana 
Published: April 2020

The lambari, Astyanax altiparanae, exhibits a great potential for aquaculture due to its omnivory, rapid growth and ease captive production. Despite of fish lipid metabolism being directly related to the dietary lipid consumed, which may lead to changes in fish growth, nothing much have been established regarding the lipid sources that can be applied in A. altiparanae captive production. Thus, this present research was conducted aiming to evaluate the growth performance and whole body composition of A. altiparanae fed with lipid sources of plant and/or animal origins. Were used a Completely Randomized design experiment with five treatments. The treatments consisted of isoproteic and isoenergetic diets, containing the following lipid sources: T1: linseed, chia and sunflower oils; T2: linseed and corn oils; T3: linseed, chia, corn and sunflower oils; T4: sunflower, corn and fish oils; T5: linseed, chia, sunflower, corn oils and bovine fat. Each treatment was replicated six times, where the experimental units consists of 10 fishes (averaged weight: 4.0 + 0.5 g) placed in an aquarium containing 80L of dechlorinated water. Were compared the growth performance parameters among the treatments by applying an one-way analysis of variance (ANOVA) at 5% significance (P < 0.05). The results revealed that both growth performance and whole body composition of A. altiparanae were not affected by the lipid source, which indicate that these fishes can efficiently use both vegetable lipid sources as well as mixtures of vegetable and animal lipid sources without any growth disadvantages.
RESENHA: THE MODEL AS PERFORMANCE: STAGING SPACE IN THEATRE AND ARCHITECTURE
Authors: Drago Niuxa Dias 
Published: April 2020

O livro trata do modelo em escala, tanto na arquitetura como na cenografia, e suas potencialidades performáticas. Os autores estabelecem uma distinção entre modelo ilustrativo, modelo iterativo e modelo autônomo, e dedicam sua análise a este último. Além de uma revisão histórica de modelos paradigmáticos para os campos em análise, enxergam nas tendências atuais da Bienal de Veneza e da Quadrienal de Praga uma valorização dos conceitos espaciais através do uso do modelo autônomo. Palavras-chave Campo Ampliado. Modelo Cenográfico. Modelo Arquitetônico.
OS IMAGINÁRIOS DA MOSTRA DOS PAÍSES E REGIÕES, PQ 2019: MATERIALIDADE, PRECARIEDADE E PERFORMANCE
Authors: Rebouças Renato Bolelli 
Published: April 2020

O presente artigo analisa, por diversas vias, algumas propostas curatoriais para a Mostra dos Países e Regiões da 14ª edição da Quadrienal de Praga de Espaço e Desenho da Cena, realizada em 2019 no Palácio Industrial Vystaviste, na cidade de Praga. São abordados diferentes procedimentos de ocupação espacial e relacionamento com o público, assim como a discussão sobre diferentes compreensões sobre o fazer cenográfico contemporâneo. Ainda, analiso como algumas propostas curatoriais enfocam e abordam temas como performatividade, política, globalização, materialidade e precariedade. Palavras-chave Mostra Nacional. Quadrienal de Praga. Performatividade. Materialidade. Precariedade.