bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasi-DNS Dataset of a Piloted Flame with Inhomogeneous Inlet Conditions
Authors: Zirwes Thorsten , Zhang Feichi , Habisreuther Peter , Hansinger Maximilian , Bockhorn Henning , Pfitzner Michael , Trimis Dimosthenis 
Published: November 2019

AbstractA quasi-DNS of the partially premixed turbulent Sydney flame in configuration FJ200-5GP-Lr75-57 has been conducted using detailed molecular diffusion for multi-component mixtures and complex reaction mechanisms. In order to study flame dynamics like regime transition in this flame for the development of new combustion models and to directly compare the quasi-DNS to different LES models, the simulation results are compiled into a data base. Because the simulation was performed with OpenFOAM, we demonstrate the quasi-DNS capabilities of OpenFOAM by performing canonical test cases. They attest that OpenFOAM’s cubic discretization has lower numerical diffusion compared to classical central difference schemes and can reach higher than second order convergence rate in some cases. The quasi-DNS of the Sydney flame is conducted with a self-developed reacting flow solver which is able to accurately compute molecular diffusion coefficients from kinetic gas theory and employs a fast implementation for detailed reaction mechanisms. The computational mesh is shown to be able to resolve the flow as well as the flame front sufficiently for the quasi-DNS. Comparisons with experimental data also show that the simulation can quantitatively reproduce measured time-mean and time-RMS statistics.
Ethical Judgments About Social Entrepreneurship in Sub-Saharan Africa: The Influence of Spatio-Cultural Meanings
Authors: De Avillez Maria Margarida , Greenman Andrew , Marlow Susan 
Published: November 2019

AbstractWithin this paper, we adopt a qualitative process approach to explore how ethical judgments are influenced by spatio-cultural meanings applied to social entrepreneurship in the context of Mozambique. We analyse how such ethical judgments emerged using data gathered over a 4 year period in Maputo. Our findings illustrate three modes used to inform ethical judgments: embracing, rejecting and integrating. These describe how ethical judgments transpire as participants evaluate social entrepreneurship drawing upon related global normative meanings and those embedded within the local context. This analysis offers a critical contribution regarding how ethical judgments regarding social entrepreneurship evolve from negotiation and interaction within a context of multiple spatio-cultural meanings.
The Variation of Geomagnetic Storm Duration with Intensity
Authors: Haines C. , Owens M. J. , Barnard L. , Lockwood M. , Ruffenach A. 
Published: November 2019

Abstract
Variability in the near-Earth solar wind conditions can adversely affect a number of ground- and space-based technologies. Such space-weather impacts on ground infrastructure are expected to increase primarily with geomagnetic storm intensity, but also storm duration, through time-integrated effects. Forecasting storm duration is also necessary for scheduling the resumption of safe operating of affected infrastructure. It is therefore important to understand the degree to which storm intensity and duration are correlated. The long-running, global geomagnetic disturbance index, $\mathit{aa}$aa, has recently been recalibrated to account for the geographic distribution of the component stations. We use this $\mathit{aa}_{H}$aaH index to analyse the relationship between geomagnetic storm intensity and storm duration over the past 150 years, further adding to our understanding of the climatology of geomagnetic activity. Defining storms using a peak-above-threshold approach, we find that more intense storms have longer durations, as expected, though the relationship is nonlinear. The distribution of durations for a given intensity is found to be approximately log-normal. On this basis, we provide a method to probabilistically predict storm duration given peak intensity, and test this against the $\mathit{aa}_{H}$aaH dataset. By considering the average profile of storms with a superposed-epoch analysis, we show that activity becomes less recurrent on the 27-day timescale with increasing intensity. This change in the dominant physical driver, and hence average profile, of geomagnetic activity with increasing threshold is likely the reason for the nonlinear behaviour of storm duration.
BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
Authors: Sarnyai Farkas , Szekerczés Timea , Csala Miklós , Sümegi Balázs , Szarka András , Schaff Zsuzsa , Mandl József 
Published: November 2019

AbstractAcetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage. Effect of BGP-15 was further investigated on mitochondria in APAP-overdose induced acute liver injury in mice. We found that BGP-15 efficiently preserved mitochondrial morphology, and it caused a marked decrease in the number of damaged mitochondria. Attenuation of mitochondrial damage by BGP-15 is supported by immunohistochemistry as the TOMM20 label and the co-localized autophagy markers detected in the livers of APAP-treated mice were markedly reduced upon BGP-15 administration. This effect, along with the observed prevention of JNK activation likely contribute to the mitochondrial protective action of BGP-15.
Public Perceptions of a New MRT Service: a Pre-launch Study in Jakarta
Authors: Dahlan Ahmad Faisal , Fraszczyk Anna 
Published: November 2019

Abstract
Jakarta Mass Rapid Transit (MRT) is the first rapid transit system in Indonesia, built with the aim of alleviating the severe congestion in Jakarta by offering a travel alternative to people using private vehicles. Although Jakarta MRT is the most sophisticated inland transport mode in Jakarta, prior to its launch, there was no evidence or guarantee that the local community was willing to use it. Hence, the pre-launch study of a non-operational public transport system was introduced to better understand perceptions of the new MRT service in Jakarta from its potential future customers’ perspective as well as their willingness to use it. A survey was conducted on 516 respondents in Jakarta and three surrounding areas of Depok, Tangerang, and Bekasi. The collected data was divided into two respondent groups: ‘MRT corridor areas’ (the MRT group), which includes Central and South Jakarta residents, and ‘other areas’ (the other group), which includes residents from all the other surrounding areas. The key finding of the study is that a great majority of the respondents from both groups declared a willingness to undertake a mode shift to Jakarta MRT services in the future. Various statistically significant differences were identified between the two groups. Moreover, respondents ranked six factors in the order of priority when selecting a transport mode, with reliability and safety issues identified as the most important. A set of key recommendations, addressed to the Jakarta MRT operator, is listed in order to optimize the MRT’s role in alleviating congestion in Jakarta. The study approach presented in this paper could be applied by other cities considering introduction of a new (transport or) metro system in order to understand its potential customers’ perceptions and expectations toward the new service.
The Best possible Time resolution: How precise could a Radiocarbon dating method be?
Authors: Svetlik I , Jull A J T , Molnár M , Povinec P P , Kolář T , Demján P , Pachnerova Brabcova K , Brychova V , Dreslerová D , Rybníček M , Simek P 
Published: November 2019

ABSTRACTToday, accelerator mass spectrometry (AMS) technology enables us to carry out very precise measurements of radiocarbon (14C). Unfortunately, due to fluctuations in the 14C calibration curve, the resulting calibrated time intervals vary from decades up to centuries in calibrated age. Within a time scale of several decades, we can find several time intervals on the 14C calibration curve which correspond with periods of rapid increases in atmospheric 14CO2 activity. Some of these “high slope” parts of the calibration curve could be used for fine time resolution for radiocarbon dating of individual samples. Nevertheless, there are certain limitations owing to the properties of the samples measured. We have prepared a time-resolution curve for the 14C dating method, applying calibration curve IntCal13 and assuming an uncertainty of 14C analyses ±15 yr BP (for recent samples). Our curve of the time resolution covers the last 50 ka. We found several time intervals with time resolution below 50 yr BP for the last 3 ka. Several time intervals which can enable substantially better time resolution compared to neighboring parts of the calibration curve were also found for periods older than 3 ka.
Is informal care sufficient to meet the long-term care needs of older people with disabilities in China? Evidence from the China Health and Retirement Longitudinal Survey
Authors: Yang Wei , Tan Si Ying 
Published: November 2019

AbstractRapid demographic shifts and socio-economic changes are fuelling concerns over the inadequate supply of informal care – the most common source of care-giving for older people in China. Unmet long-term care needs, which are believed to cause numerous adverse effects on health, continue to increase. Drawing data from the 2015 wave of the China Health and Retirement Longitudinal Survey, this study explores the relationship between informal care provision and unmet long-term care needs among older people in China. We first examine the availability of informal care among older people with disabilities. We then analyse whether a higher intensity of informal care leads to lower unmet needs. Our findings suggest that the majority of older people with disabilities receive a low intensity of care, i.e. less than 80 hours per month. Besides, a higher intensity of informal care received could significantly lower the probabilities of unmet needs for the disabled older adults who have mainly instrumental activities of daily living limitations. Our study points out that informal care cannot address the needs of those who are struggling with multi-dimensional difficulties in their daily living. Our findings highlight a pressing need for the government to buttress the formal care provision and delivery systems to support both informal care-givers and disabled older people in China.
Negative Political Communication on Social Media and the Gender Gap: A Study of Men's and Women's Reactions to Presidential Candidate Attacks on Facebook in 2012 and 2016
Authors: Phillips Justin Bonest 
Published: November 2019

AbstractDo men and women respond differently to negative political communication? Only a limited collection of studies into the effects of negative campaigns have investigated this research question, and the conflicting results produced from such studies have prevented the development of a widely accepted answer. As campaigns transition to new media environments, further problems arise, as any potential gender gap may be magnified on the new political communication battlefield of social media. The present article contributes to this sparsely investigated area through an empirical study of men's and women's reactions on Facebook to US presidential candidate attacks during two general election campaigns (2012 and 2016) and two primaries (2016 Democratic and Republican). Across nearly 400 million reactions and 40 million unique users, women demonstrate lower receptivity to candidate attacks than men. Two potential explanatory factors for the gap are examined, but neither fully captures the magnitude of the differences observed. Conceptualizing the gender gap composition in terms of differential receptivity most accurately explains these findings and potentially resolves the competing explanations for the gap within the existing literature.
Evaluation of Regional Climate Models Using Regionally Optimized GRACE Mascons in the Amery and Getz Ice Shelves Basins, Antarctica
Authors: Mohajerani Yara , Velicogna Isabella , Rignot Eric 
Published: November 2019

AbstractWe develop regionally optimized Gravity Recovery and Climate Experiment (GRACE) solutions to evaluate the mass balance of the drainage basins of Amery Ice Shelf, East Antarctica, and Getz Ice Shelf, West Antarctica. We find that the Amery region is near balance, while the Getz region is rapidly losing mass. We compare the results with the mass budget method (MBM) combining ice discharge along the periphery with surface mass balance derived from three regional climate models: (1) Regional Atmospheric Climate Model (RACMO) 2.3p1 and (2) 2.3p2, and (3) Modèle Atmosphérique Régional 3.6.41. For Amery, MBM/RACMO2.3p1 agrees with GRACE, while MBM/RACMO2.3p2 and MBM/MAR3.6.41 suggest a positive mass balance. For Getz, all estimates agree with a mass loss and the GRACE results are robust to uncertainties in glacial isostatic adjustment derived from an ensemble 128,000 forward models. Over the period April 2002 to November 2015, the mass loss of the Getz drainage basin is 22.9 ± 10.9 Gt/yr with an acceleration of 1.6 ± 0.9 Gt/yr2.
Midlatitude Southern Hemisphere Temperature Change at the End of the Eocene Greenhouse Shortly Before Dawn of the Oligocene Icehouse
Authors: Haiblen A. M. , Opdyke B. N. , Roberts A. P. , Heslop D. , Wilson P. A. 
Published: November 2019

AbstractThe Eocene‐Oligocene transition (EOT) marked the initiation of large‐scale Antarctic glaciation. This fundamental change in Cenozoic climate state is recorded in deep‐sea sediments by a rapid benthic foraminiferal δ18O increase and appearance of ice‐rafted debris in the Southern Ocean. However, we know little about the magnitude of cooling associated with the EOT in shallow water environments, particularly at middle to high latitudes. Here we present new stratigraphic records of the C13r/C13n magnetochron boundary and the EOT in the clay‐rich Blanche Point Formation, South Australia. The Blanche Point Formation was deposited in a shallow shelf setting (water depths of <100 m) at a paleolatitude of ~51°S. We present high‐resolution δ18O, δ13C, and Mg/Ca records of environmental change from well‐preserved benthic foraminifera of latest Eocene age at this site. A marked, negative δ13C excursion occurs immediately before EOT Step 1 and may be a globally representative signal. An ~2 °C cooling of shallow shelf seawater is evident from benthic foraminiferal Mg/Ca across Step 1. This cooling signal is both sufficient to account fully for the δ18O increase in our data and is of similar amplitude to that documented in published records for shallow shelf and upper water column open ocean settings, which suggests no obvious polar amplification of this cooling signal. Our results strengthen the evidence base for attributing EOT Step 1 to global cooling with little contribution from ice volume growth and contradict the mechanism suggested to explain the inferred northward migration of the intertropical convergence zone in the contemporaneous equatorial Pacific Ocean.
Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells
Authors: Trittel Stephanie , Chambers Benedict J. , Heise Ulrike , Guzmán Carlos A. , Riese Peggy 
Published: November 2019

AbstractThe contribution of natural killer (NK) cells to the clearance of hepatic viral infections is well recognized. The recently discovered heterogeneity of NK cell populations renders them interesting targets for immune interventions. Invariant natural killer T (iNKT) cells represent a key interaction partner for hepatic NK cells. The present study addressed whether characteristics of NK cells in the liver can be shaped by targeting iNKT cells. For this, the CD1d-binding pegylated glycolipid αGalCerMPEG was assessed for its ability to modulate the features of NK cells permanently or transiently residing in the liver.In vivoadministration resulted in enhanced functionality of educated and highly differentiated CD27+Mac-1+NK cells accompanied by an increased proliferation. Improved liver homing was supported by serum-derived and cellular factors. Reduced viral loads in a mCMV infection model confirmed the beneficial effect of NK cells located in the liver upon stimulation with αGalCerMPEG. Thus, targeting iNKT cell-mediated NK cell activation in the liver represents a promising approach for the establishment of liver-directed immune interventions.
Harnessing Paleohydrologic Modeling to Solve a Prehistoric Mystery
Authors: Levy Yehuda , Goring-Morris Nigel A. , Yechieli Yoseph , Burg Avihu , Gvirtzman Haim 
Published: November 2019

AbstractA riddle arises at the Epipaleolithic and Neolithic sites that dot the lower Jordan Valley. The area has no water resources yet it has long been a focus of inquiry into the transition from mobile hunter-gatherer to sedentary agriculture-based cultures. How then is there such clear evidence of life here, and particularly at such a critical moment in human evolution? Keen to unravel this conundrum, a numerical hydrological model was devised to simulate the groundwater flow field within the Eastern Aquifer of the Judea and Samaria Mountains during the transition from the last glacial to the current interglacial. The model exhibits a range of groundwater flow regimes that prevailed in the past, demonstrating that there was once much larger groundwater discharge at these sites.
Pain-Evoked Reorganization in Functional Brain Networks
Authors: Zheng Weihao , Woo Choong-Wan , Yao Zhijun , Goldstein Pavel , Atlas Lauren Y , Roy Mathieu , Schmidt Liane , Krishnan Anjali , Jepma Marieke , Hu Bin , Wager Tor D 
Published: November 2019

Abstract
Recent studies indicate that a significant reorganization of cerebral networks may occur in patients with chronic pain, but how immediate pain experience influences the organization of large-scale functional networks is not yet well characterized. To investigate this question, we used functional magnetic resonance imaging in 106 participants experiencing both noxious and innocuous heat. Painful stimulation caused network-level reorganization of cerebral connectivity that differed substantially from organization during innocuous stimulation and standard resting-state networks. Noxious stimuli increased somatosensory network connectivity with (a) frontoparietal networks involved in context representation, (b) “ventral attention network” regions involved in motivated action selection, and (c) basal ganglia and brainstem regions. This resulted in reduced “small-worldness,” modularity (fewer networks), and global network efficiency and in the emergence of an integrated “pain supersystem” (PS) whose activity predicted individual differences in pain sensitivity across 5 participant cohorts. Network hubs were reorganized (“hub disruption”) so that more hubs were localized in PS, and there was a shift from “connector” hubs linking disparate networks to “provincial” hubs connecting regions within PS. Our findings suggest that pain reorganizes the network structure of large-scale brain systems. These changes may prioritize responses to painful events and provide nociceptive systems privileged access to central control of cognition and action during pain.
SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures
Authors: Armas-Capote Natalia , Maglio Laura E , Pérez-Atencio Leonel , Martin-Batista Elva , Reboreda Antonio , Barios Juan A , Hernandez Guadalberto , Alvarez de la Rosa Diego , Lamas José Antonio , Barrio Luis C , Giraldez Teresa 
Published: November 2019

Abstract
Approaches to control epilepsy, one of the most important idiopathic brain disorders, are of great importance for public health. We have previously shown that in sympathetic neurons the neuronal isoform of the serum and glucocorticoid-regulated kinase (SGK1.1) increases the M-current, a well-known target for seizure control. The effect of SGK1.1 activation on kainate-induced seizures and neuronal excitability was studied in transgenic mice that express a permanently active form of the kinase, using electroencephalogram recordings and electrophysiological measurements in hippocampal brain slices. Our results demonstrate that SGK1.1 activation leads to reduced seizure severity and lower mortality rates following status epilepticus, in an M-current–dependent manner. EEG is characterized by reduced number, shorter duration, and early termination of kainate-induced seizures in the hippocampus and cortex. Hippocampal neurons show decreased excitability associated to increased M-current, without altering basal synaptic transmission or other neuronal properties. Altogether, our results reveal a novel and selective anticonvulsant pathway that promptly terminates seizures, suggesting that SGK1.1 activation can be a potent factor to secure the brain against permanent neuronal damage associated to epilepsy.
Archivory in hypersaline aquatic environments: Haloarchaea as a dietary source for the brine shrimp Artemia
Authors: Lopes-dos-Santos R M A , De Troch Marleen , Bossier Peter , Van Stappen Gilbert 
Published: November 2019

ABSTRACT
Archaea have been the most overlooked and enigmatic of the three domains of life for decades. Knowledge of key ecological interactions such as trophic links between this domain and higher level organisms remains extremely limited. The co-occurrence of halophilic Archaea (haloarchaea) and the non-selective filter feeder, brine shrimp Artemia under the unique ecological characteristics of hypersaline aquatic environments, constitutes an excellent opportunity to further unravel the ecological role of the Archaea domain as a source of food to zooplankton metazoans. In the present study, we combine the use of haloarchaea biomass assimilation experiments using 13C isotope as tracer, with gnotobiotic Artemia culture tests using haloarchaea mono-diets, to investigate potential trophic links between the organisms. Our results demonstrated the ability of Artemia to assimilate nutrients from mono-diets of haloarchaea biomass in order to survive and grow, providing clear indications that archivory may occur in hypersaline aquatic environments. Additionally, our study highlights the use of stable isotopes labelling as a potential tool to further disentangle the specific pathways by which archaeal cellular constituents are digested by consumers.
Morphological, cytological and genetic analyzes of the ‘sango’ mutant with the defects in basidiocarp development in edible mushroom Pleurotus pulmonarius
Authors: Okuda Yasuhito , Ito Mikinari , Shimada Yu , Ishigami Masato , Matsumoto Teruyuki 
Published: November 2019

ABSTRACT
A spontaneous, morphological variation ‘sango’ was observed in the progeny of a Pleurotus pulmonarius (Fr.) Quél. wild-type basidiocarp (also known as fruiting body) collected from the field. This variant developed wart- and coral-like structures instead of normal basidiocarps. Microscopic analysis showed that the sango phenotype had defects in the differentiation of the pileus and hymenium. Basidiocarp phenotypic data analysis in the progenies revealed that the sango trait is a heritable mutation character controlled by a single recessive gene. This mutation locus was mapped on linkage group III of a previously constructed genetic linkage map by amplified fragment length polymorphism (AFLP) technique in P. pulmonarius. Four AFLP markers identified by bulked segregant analysis showed linkage to the sango mutation locus, with the genetic distance ranging from 0 to 2.1 cM. Of these markers, one marker was co-segregated with the sango mutation locus. This knowledge will be a useful foundation for practical breeding as well as for elucidating molecular mechanisms in basidiocarp development of main edible mushrooms.