bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysfunction of cerebellum functional connectivity between default mode network and cerebellar structures in patients with mild traumatic brain injury in acute stage. rsfMRI study
Authors: Ublinskiy M. V. , Semenova N. A. , Manzhurtsev A. V. , Menshchikov P. E. , Yakovlev A. N. , Akhadov T. A. 
Published: June 2020

Mild traumatic brain injury (mTBI) is the most common neurological damage in children that's why it is extremely important to identify and analyze biomarkers that can help in predicting patient's treatment and recovery in period of mTBI. Aim of this study is to verify a hypothesis that functional connectivity disturbances between intact cerebellum and DMN nodes are included in symptomatic manifestation of mTBI.Methods. 28 MR negative patients with mTBI were studied in age from 12 to 17 years (mean age – 14.7 years). The control group consisted of 23 healthy children. All MRI studies wereperformed on a Philips AchievadStream 3.0 T scanner equipped with a 32-channelPhilips dStream head coil. A 4 min rsfMRI gradient-echo echo planar imaging (EPI)sequence was acquired (TR = 3000 ms, echo time (TE) = 30 ms, 80 dynamics withdynamic scan time = 3 s). fMRI data were processed using functional connectivitytoolbox CONN.Results. No statistically significant differences in correlation strengths between control group and group of patients were detected as a result of DMN analysis. Intergroup seed-basedcorrelation ROI analysis revealed statistically significant (p < 0.05) differencein links between DMN regions and vermis (cerebellum): positive link in control group and negative link in groupof patients.Conclusions. The revealed changes in DMN neuronal connection and cerebellar regions in acute stage of mTBI patients can be an initial step of damages leading to cognitive deficit which can be developed in future.
Biochemical basics of imaging in positron emission tomography in oncology. Part 3
Authors: Leontyev A. V. , Rubtsova N. A. , Khalimon A. I. , Khamadeeva G. F. , Kuliev M. T. , Pylova I. V. , Lazutina T. N. , Kostin A. A. , Kaprin A. D. 
Published: June 2020

This article provides an overview of the main literature data of biochemical basics and the clinical application of positron emission tomography, one of the promising technologies of radiation imaging in oncology.In the final part, the biokinetics of radiopharmaceuticals that display the proliferative activity of malignant cells and the degree of hypoxia in the tumor focus are examined in detail. The results of studies devoted to assessing their effectiveness, the main indications for their use, the features of preparation for the study, as well as promising scientific developments in this industry are presented.
Perceptions of teachers, principals and school supervisors on students' skills using ICT in learning in the Senior High School
Authors: Rahmatina Desi , Zaid Norasykin Mohd 
Published: June 2020

This study examined on status of school (public and private school) differences for the perceptions of participats (teachers,principals and school supervisors ) in eleven senior high school on the students skills of Information and Communication Technology (ICT) in Tanjungpinang city, Kepulauan Riau Province,Indonesia. Data was taken by the use of online survey in 2016 who conducted by the Directorate General of Primary and Secondary Education of the Republic of Indonesia. We accumulate data from 310 respondents, they are 11 principals, 9 supervisors and 290 teachers on the eleven senior high school of Tanjungpinang district, Kepulauan Riau Province, Indonesia. Data analysis was done using quantitative analysis, the first using descriptive statistics mainly percentages perceptions of the principal, supervisor and teachers toward skill’s students using ICT in learning, the second to inferential statistical analysis of non parametric statistics Mann Whitney to test alternative hypothesis that there are significant difference skill’s students among public school and private school. SPSS software was used to analyze data.The results of the study shown that no different significantly on the students skill on use of computer in learning between public and private school (sig = 0.057), and there are different significantly on the students skill on use of mobile phone in learning between public and private school (sig = 0.001) and last result showed that there are different significantly on the students skill on use of internet in learning between public and private school (sig = 0.026).
Understanding of farmers' perception of climate change and adaptation strategies: A case study in Jhargram district of West Bengal, India
Authors: Biswas Soma , Chatterjee Souradeep , Roy D. C. 
Published: June 2020

A study on farmers perceived prevalence of climate change, manifested by the phenomena like increasing temperature, fluctuating rainfall etc. and in the considered agro-ecological areas was conducted in Binpur II block of Jhargram district of West Bengal to assess the extent of farmers' perception about the climate change and their adaptation strategies to cope up with losses due to climate change. Results showed that the farmers' perception of climate change greatly influenced farmers' readiness to adapt climate change by considering some adjustments to their cultivation and production practices. The findings showed that the farmers' perception of climate change was at a high-level group of respondents. Results showed that 50% of respondents were optimistic with the idea that they can cope up the climate change problems if they get proper government assistance. Only about 13% of farmers perceived Government plans on climate change. Regarding the adaptation strategies, 40% of respondents followed more or less strategies, whereas most of the respondents did not adopt any strategies in this regard.
Correlation analysis for adoption studies of rice growers in district Baramulla of Kashmir Division, India
Authors: Sreekanth Maddina , Peer Quadri Javeed Ahmad , Saraf Sajad.A. , Ganai N. A. 
Published: June 2020

This study about the correlation analysis for adoption and knowledge of rice growers was carried in 12 randomly selected villages of 3 tehsils prominently growing rice of district Baramulla of J&K state. After multi-stage random 10 rice growers from each village were selected randomly and systematic sampling technique a sample of 120 rice farmers was drawn. It was found that Knowledge were found positively correlated with Education (0.449) Occupation (0.356), Social participation (0.205), annual income (0.229), Mass media exposure (0.375), Extension contacts (0.219) and Scientific orientation (0.341) and Adoption were also found positively correlated with Education (0.447) Occupation (0.348), Social participation (0.301), Annual income (0.243), Mass media exposure (0.309), Extension contacts (0.243) and Scientific orientation (0.338) whereas Age, Family size, Land holding and Farming experience have no significance with knowledge and adoption level of famers. The significance at 0.01 level of variables like Education, Occupation, Social Participation, Annual income, Mass Media Exposure, Extension contacts and Scientific Orientation with dependent variable Knowledge and adoption level of rice growers. The results of the study indicated that these selected variables might play a very important role in increasing the Knowledge and adoption level of the package of practices by rice growers of Kashmir Division.
Evaluation of fungicides for management of anthracnose disease of black gram (Vigna mungo l.) in growing areas of district Jhansi of Bundelkhand region
Authors: Kumar Adesh , Rawal Roomi , Roy Nishi , Ahamad Atik , Kumar Hitesh 
Published: June 2020

Black gram (Vigna mungo L.) growing areas of district Jhansi coming under Bundelkhand region of Uttar Pradesh were surveyed during Kharif 2018 for the occurrence of anthracnose disease of black gram. A total of 22 villages were visited under six blocks of Jhansi during this period. Blockwise comparison of the survey in Jhansi revealed that less mean disease incidence (10%) and severity (4.0%) occurred in the Chirgaon block. Highest disease incidence (24%) and severity (12%) were observed in block Moth. The block Bangra, Babina, Badagaon, and Bamour secured disease incidence 23.5, 20, 16.44 and 15% and severity 15.14, 12, 7.44 and 8.5% respectively. Nine fungicides (viz. folicur@0.1%, tilt @0.1%, natio@0.0.5%, saaf@0.2%, bavistin@0.2%, dithane Z-78@0.2%, amistar top, kavach@0.2% and blitox@0.2%) were tested against anthracnose disease of black gram under field condition. Among them, seed treatment with carbendazim@ 3gram/kg seed and foliar spray of mixture of azole and strobilurin group T3- natio@0.05 ( tebuconazole + trifloxystrobin) and T7-amistar top@0.1% (azoxystrobin+ difenoconazole) were found significantly (at 0.05%) superior over the rest of treatments, both showed minimum (6%) disease severity with maximum (78.51%) disease control. Significant (at 0.05%) increase in yield (47.5%) also observed in both treatments T3 and T7. The treatment T1- Spray of Folicur@0.1%, T2- Spray of Tilt @0.1%, T4- Spray of Saaf@0.2%, T5- Spray of Bavistin@0.2%, T8- Spray of Kavach@0.2%, T9- Spray of Blitox@0.2% also showed good results in reducing the black gram anthracnose disease severity per cent (64.29, 57.14, 64.28, 57.14, 71.42 and 64.28 and also increased the yield per cent 37.5, 35, 42.5, 36.25, 45 and 45 respectively.
Xenia studies in exotic and indigenous almond (Prunus amygdalus L.) varieties of Kashmir, India
Authors: Majid Shabeena , Kumar Amit , Bashir Sabia , Seerat-ul-Nisa  , Amin Asima , Nagoo Shaheena Ahmad , Rashid Zahida , Dar Z. A. , Paul Saima 
Published: June 2020

Pollination is very important to obtain an economic yield, and the selection of pollinizer with suitable quality and quantity of pollen is an essential practice in different fruit plants. The effects of pollen parent on kernel and nut characters are known to occur in several nut crops and to determine the best pollinizer and effect of pollen source on the nut and kernel quality of almond (Prunus amygdalus L.). The present investigation was carried out at the experiment farm of Dryland Agriculture Research Station (DARS), SKUAST-Kashmir for two consecutive years, i.e. 2008 and 2009. Various cross combinations were made among nine almond (three exotic and six indigenous) varieties/selections which are compatible with each other. Their nut and kernel characteristics were determined and observed maximum nut weight (2.21 g), nut length (39.78 mm) and nut breadth (20.33 mm), kernel weight (1.28 g), kernel length (28.63 mm) and kernel breadth (12.61 mm) and shelling percentage (57.99 %). In the present study it has been observed that the parent with big nut and kernel size and weight influenced the nut and kernel size; nut and kernel weight of the recipient parent significantly (p?0.05).
Fixation of soluble forms of fertilizer phosphorus in salt affected soils of Ramanathapuram and Trichy districts and acid soil of Ariyalur district of Tamil Nadu
Authors: Thamaraiselvi R, , Arulmozhiselvan K. 
Published: June 2020

Soluble phosphorus (P) applied through phosphatic fertilizers is quickly converted into low soluble P compounds in soil. For evaluating fixation ability of P fertilizers laboratory incubation experiments were conducted with saline, sodic and acid soils. Phosphatic fertilizers selected were single super phosphate (SSP), diammonium phosphate (DAP), monoammonium phosphate (MAP), monopotassium phosphate (MPP) and 19:19:19 N, P2O5, K2O % (All-19). Fixation of P was computed based on the amount of P recovered after addition of P in the soil in increasing levels. At a typical P addition at 16 kg ha-1 the results were compared in all soils. In saline soil, high fixation of P occurred when DAP (12.18 kg ha-1) and MPP (11.28 kg ha-1) were applied. In sodic soil, high fixation of P resulted when SSP (7.10 kg ha-1) was applied. In acid soil, high fixation of P occurred when All -19 (12.64 kg ha-1), MAP (12.40 kg ha-1), SSP (12.22 kg ha-1), and DAP (11.74 kg ha-1) were applied. With all forms of phosphatic fertilizers fixation of added P occurred to the extent of 57.9 to 79.0 per cent in acid soil, 55.0 to 70.5 per cent in saline soil and 25.5 to 44.4 per cent in sodic soil. In saline soil availability of P might be higher for SSP and All-19 compared to ammonium/ potassium phosphate fertilizers. On the other hand, MPP, MAP and All-19 may be preferably applied in sodic/ acid soils alternative to SSP or DAP for realizing higher P release in soils from added fertilizers for the benefit of crop utilization.
Influencia del síndrome de pseudoexfoliación capsular en la pérdida auditiva
Authors: Real Juan Pablo , Campana Vilma , Luna Consuelo , Acosta Luciana , Coronel Mariana , Gomez-Demmel Eduardo , Tartara Luis Ignacio 
Published: June 2020

Introducción: El Síndrome de Pseudoexfoliación (PEX) es un trastorno genético-hereditario, consiste en el depósito de microfibras de elastina en tejido intra y extraocular. El PEX es una de las causas secundarias identificables más comunes del glaucoma. Varios estudios han asociado el PEX con afecciones sistémicas y se ha descripto el hallazgo de material fibrilar en las estructuras del oído interno, similares al de pseudoexfoliación detectado en el ojo.
Objetivo: comparar los niveles de audiométricos en pacientes con y sin PEX ocular.
Materiales y Métodos: Estudio retrospectivo de casos y controles. Se seleccionaron 48 historias clínicas de pacientes que asistieron al servicio de oftalmología del Hospital Privado de Córdoba, entre enero del 2015 y diciembre de 2017, de entre 59 y 75 años. Se los dividió en grupos: controles (n=22): sin PEX y casos (n=26): con PEX. Se analizaron las historias clínicas de pacientes a los que se les realizaron estudios oftalmológicos y audiométricos. Para el análisis estadístico se utilizó el test T de Student para muestras independientes y apareadas; en todos los casos se consideró un nivel de significación ≤ 0.05.
Resultados: El porcentaje de pérdida auditiva fue del 56,8% en el grupo control y un 82,7% en el grupo PEX. La incapacidad porcentual en el grupo con PEX fue mayor en la audición monoaural (p=0,0008) y biaural (p=0,0307) con respecto a los pacientes sin PEX.
Conclusión: Los pacientes con PEX ocular mostraron un porcentaje mayor de hipoacusia, en comparación con aquellos pacientes sin evidencia oftalmológica de PEX.
Godność ludzka jako wartość i sposoby jej uzasadniania w opinii młodzieży
Authors: Mariański Janusz 
Published: June 2020

Uzasadnienie godności ludzkiej przebiega na płaszczyźnie przyrodzonej (filozoficznej) i nadprzyrodzonej (teologicznej) lub intuicyjnej. W artykule dokonano analizy i interpretacji wypowiedzi młodzieży szkolnej i akademickiej dotyczących uznawanych przez nią uzasadnień godności. Zostały ustalone następujące kategorie uzasadnień: a) godność ludzka jako gwarancja i przejaw życia moralnego (22,4% ogółu badanych osób); b) godność uzasadniana przez inne wartości (15,8%); c) godność jako człowieczeństwo (9,7%); d) godność jako coś danego, nieutracalnego (7,9%); e) godność jako wartość szczególnie ważna (7,9%); f) godność jako wartość teologiczna (7,9%); g) godność jako wartość wychowawcza (3,6%); h) godność jako coś, czego się nie przestrzega (3,0%); i) godność jako cecha odróżniająca człowieka od innych bytów (2,4%); inne wypowiedzi (2,4%). W całej zbiorowości młodzieży 13,9% ankietowanych zrezygnowało z udzielenia odpowiedzi, a 3,1% udzieliło odpowiedzi negatywnych. Większość ankietowanej młodzieży myśli o godności pozytywnie, choć dość często w niepogłębiony sposób, i wiąże z nią różnorodne treści. Uzasadnienia teologiczne pojawiają się dość sporadycznie.
A Comprehensive, Multi-Modal Strategy to Mitigate Alzheimer’s Disease Risk Factors Improves Aspects of Metabolism and Offsets Cognitive Decline in Individuals with Cognitive Impairment
Authors: Schechter Ginger , Azad Gajendra Kumar , Rao Rammohan , McKeany Allison , Matulaitis Matthew , Kalos Denise M. , Kennedy Brian K. 
Published: June 2020

Background: Alzheimer’s disease (AD) is a chronic condition that progresses over time. While several therapeutic approaches have been developed, none have substantially altered disease progression. One explanation is that the disease is multi factorial. Objective: Using the Affirmativ Health Personal Therapeutic Program (PTPr), we sought to determine whether a comprehensive and personalized program could improve cognitive and metabolic function in individuals diagnosed with subjective cognitive impairment, mild cognitive impairment, and early stage AD. Methods: 35 individuals submitted blood samples and Montreal Cognitive Assessment (MoCA) scores, and answered intake questions. Individuals and caregivers participated in a four-day immersion program, which included Personal Therapeutic Plans (PTP), consultations with clinical practitioners, and explanations of the PTPr and PTP. Participants had follow-up by telemonitoring, with repeat blood sample analysis, updates regarding lifestyle choices, current medications and supplements, and MoCA testing at least once between 3 and 12 months after the PTPr. Results: By comparing baseline to follow-up testing, we determined several risk factor scores, including blood glucose and insulin levels, and levels of vitamins B12, D3, and E, improved either in the entire participant pool or specifically in individuals with measures outside the normal range for specific factors. MoCA scores were stabilized in the entire participant pool and significantly improved in individuals scoring 24 or less at baseline. Conclusion: Our findings provide evidence that a comprehensive and personalized approach designed to mitigate AD risk factors can improve risk factor scores and stabilize cognitive function, warranting more extensive and placebo-controlled clinical studies.
Assessing the Utility of Language and Voice Biomarkers to Predict Cognitive Impairment in the Framingham Heart Study Cognitive Aging Cohort Data
Authors: Thomas Jason A. , Burkhardt Hannah A. , Chaudhry Safina , Ngo Anthony D. , Sharma Saransh , Zhang Larry , Au Rhoda , Hosseini Ghomi Reza 
Published: June 2020

Background: There is a need for fast, accessible, low-cost, and accurate diagnostic methods for early detection of cognitive decline. Dementia diagnoses are usually made years after symptom onset, missing a window of opportunity for early intervention. Objective: To evaluate the use of recorded voice features as proxies for cognitive function by using neuropsychological test measures and existing dementia diagnoses. Methods: This study analyzed 170 audio recordings, transcripts, and paired neuropsychological test results from 135 participants selected from the Framingham Heart Study (FHS), which includes 97 recordings of cognitively normal participants and 73 recordings of cognitively impaired participants. Acoustic and linguistic features of the voice samples were correlated with cognitive performance measures to verify their association. Results: Language and voice features, when combined with demographic variables, performed with an AUC of 0.942 (95% CI 0.929–0.983) in predicting cognitive status. Features with good predictive power included the acoustic features mean spectral slope in the 500–1500 Hz band, variation in the F2 bandwidth, and variation in the Mel-Frequency Cepstral Coefficient (MFCC) 1; the demographic features employment, education, and age; and the text features of number of words, number of compound words, number of unique nouns, and number of proper names. Conclusion: Several linguistic and acoustic biomarkers show correlations and predictive power with regard to neuropsychological testing results and cognitive impairment diagnoses, including dementia. This initial study paves the way for a follow-up comprehensive study incorporating the entire FHS cohort.
Mutation Analysis of the Genes Associated with Parkinson’s Disease in a Finnish Cohort of Early-Onset Dementia
Authors: Luukkainen Laura , Huttula Samuli , Väyrynen Henri , Helisalmi Seppo , Kytövuori Laura , Haapasalo Annakaisa , Hiltunen Mikko , Remes Anne M. , Krüger Johanna 
Published: June 2020

Background: Alzheimer’s disease, frontotemporal lobar degeneration, dementia with Lewy bodies, and Parkinson’s disease (PD) overlap in clinical characteristics, neuropathology, and genetics. Objective: The aim of this study was to evaluate the role of pathogenic mutations and rare variants in genes associated with PD among early-onset dementia (EOD) patients. Methods: Rare non-synonymous variants (MAF < 0.01) in ten genes ( SNCA, PARK2, PARK7, LRRK2, PINK1, ATP13A2, UCHL1, HTRA2, GBA, and SNCAIP) and low-frequency (MAF < 0.05) GBA variants were screened using a targeted next-generation sequencing panel in a strictly defined cohort of 37 early-onset (age at onset (AAO) <65 years) dementia patients presenting with atypical features (e.g., myoclonia or spasticity), rapidly progressive course of the disease or with a family history of dementia. The identified variations were further screened in a larger cohort of EOD ( n = 279, mean AAO 57, range 36–65) patients. Results: No pathogenic mutations were found, but we identified seven possible risk variants for neurodegeneration ( LRRK2 p.Arg793Met, PARK2 p.Ala82Glu, SNCAIP p.Arg240Gln, SNCAIP p.Phe369Leu, GBA p.Asn409Ser, GBA p.Glu365Lys, GBA p.Thr408Met). Discussion: Altogether, the frequency of these variants was two times higher in the first selected cohort compared to the whole cohort. This suggests that specific rare variants in the genes associated with PD might play a role also especially in familial EOD.
Towards a Redefinition of Cognitive Frailty
Authors: Mantovani Elisa , Zucchella Chiara , Schena Federico , Romanelli Maria Grazia , Venturelli Massimo , Tamburin Stefano 
Published: June 2020

Background: The progressive aging of the population will dramatically increase the burden of dementia related to Alzheimer’s disease (AD) and other neurodegenerative disorders in the future. Because of the absence of drugs that can modify the neuropathological substrate of AD, research is focusing on the application of preemptive and disease-modifying strategies in the pre-symptomatic period of the disease. In this perspective, the identification of people with cognitive frailty (CF), i.e., those individuals with higher risk of developing dementia, on solid pathophysiological bases and with clear operational clinical criteria is of paramount importance. Objective/Methods: This hypothesis paper reviews the current definitions of CF, presents and discusses some of their limitations, and proposes a framework for updating and improving the conceptual and operational definition of the CF construct. Results: The potential for reversibility of CF should be supported by the assessment of amyloid, tau, and neuronal damage biomarkers, especially in younger patients. Physical and cognitive components of frailty should be considered as separate entities, instead of part of a single macro-phenotype. CF should not be limited to the geriatric population, because trajectories of amyloid accumulation are supposed to start earlier than 65 years in AD. Operational criteria are needed to standardize assessment of CF. Conclusion: Based on the limitations of current CF definitions, we propose a revised one according to a multidimensional subtyping. This new definition might help stratifying CF patients for future trials to explore new lifestyle interventions or disease-modifying pharmacological strategies for AD and dementia.