bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of oral health education on eight to ten year old school children in rural area of Magway Region, Myanmar
Authors: Swe Kyu Kyu , Soe Aung Kyaw , Aung Saw Htun , Soe Htin Zaw 
Published: August 2020

Abstract
Background

Oral diseases are common and widespread around the world. Many oral health problems are preventable and early onset is reversible. Myanmar faces many challenges in rendering oral health services and about 70 percent of total population resides in rural areas. These relate to the availability and accessibility of oral health services. Therefore, oral health education is one key element to prevent oral diseases and to promote oral health.

Methods

A quasi-experimental study was carried out at Basic Education Middle Schools in rural areas of Magway Township to study the effectiveness of oral health education on knowledge and behavior of eight to ten years old school children. A total of 220 school children, 110 from intervention school and 110 from control school, participated in this study from 2015 to 2017. Data for knowledge and behavior were collected before and after intervention in the two groups by using self-administered questionnaire. Tooth brushing method data were collected by direct observation with checklist. Oral health education was provided at eight weekly intervals for one year in the intervention group. After one year and six months, oral health knowledge and behavior were determined in the intervention group only to measure retention. Chi-square test, two samples t test, One way repeated measure ANOVA were used for data analysis. The study was approved by the Ethics Review Committee of University of Public Health in Yangon, Myanmar.

Results

There were significant differences between the two groups in oral health knowledge (p<0.05) except one and also in behavior (p<0.001) at after intervention. A positive effect of intervention was found in intervention group. The intervention had significant effect on sustainability of correct knowledge and behavior by the school children in intervention group although education session was stopped for six months after one-year education (p<0.001). Their mean knowledge and behavioral scores at three different points in time were (2.45±1.12 and 1.56±0.90) at baseline, (3.79±1.12 and 3.60±1.21) at one year after education, and (4.07±0.98 and 3.24±1.31) at six months after cessation of education, respectively.

Conclusion

The repeated oral health education was effective to promote and sustain oral health knowledge and behavior.
Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013-2018
Authors: Li Chunyun , Zeng Huihui , Ding Xin , Chen Yi , Liu Xiaowei , Zhou Li , Wang Xin , Cheng Yumei , Hu Shanshan , Cao Zheng , Liu Ruixia , Yin Chenghong 
Published: August 2020

Abstract
Background: Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis is often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarriage and neonate death). Here we report the characteristics and outcomes of perinatal listeriosis cases treated over 6 years at Beijing Obstetrics and Gynecology Hospital (BOGH), the largest maternity hospital in China.

Methods: We retrospectively reviewed the records of laboratory-confirmed, pregnancy-associated listeriosis cases treated from January 1, 2013 to December 31, 2018. The clinical manifestations, laboratory results, perinatal complications and outcomes (post-natal follow-up of 6 months) were investigated.

Results: In BOGH, 12 perinatal listeriosis cases were diagnosed based on Listeria monocytogenes positive culture, including 10 single pregnancies and 2 twin pregnancies. The corresponding incidence of pregnancy-associated listeriosis was 13.7/100,000 deliveries. Among those cases, four pregnant women and four newborns had septicemia, and two of the neonates with septicemia also suffered CNS infection. All the maternal patients recovered. Two inevitable miscarriages and four fetal stillbirths occurred. Of the eight delivered newborns, six survived, and two died within 2 days from birth. None of the survivors had neurological sequelae during a 6-month follow-up. The overall feto-neonatal fatality rate was 57.1%; notably, this rate was 100% for infections occurring during the second trimester of pregnancy and only 14.3% for those occurring in the third trimester.

Conclusions: Perinatal listeriosis is associated with high feto-neonatal mortality, and thus, a public health concern. Additional large-scale studies are needed to strengthen the epidemiological understanding of listeriosis in China.
Socio-demographic Determinants of Low Sexual Desire and Hypoactive Sexual Desire Disorder: A Population-based Study in Iran
Authors: Hamzehgardeshi Zeinab , malary mina , moosazadeh mahmood , Khani Soghra , Pourasghar mehdi 
Published: August 2020

Abstract
Background: Various socio-demographic factors have been introduced as determinants of low sexual desire (LSD), but whether these variables can also contribute to hypoactive sexual desire disorder (HSDD) remains uncertain. In this study, we sought to identify the socio-demographic determinants of LSD and HSDD in Iranian women of reproductive age.

Methods: This was a population-based, cross-sectional study of 1000 Iranian women of reproductive age (15-49 years) who met the inclusion criteria. The participants were chosen using the systematic random sampling method from all the healthcare centers in Sari, Iran. LSD was defined as a score no higher than 33 on the Sexual Interest and Desire Inventory-Female (SIDI-F), sexually-related personal distress was considered as a score of at least 11.0 on the Female Sexual Distress Scale–Revised (FSDS-R), and HSDD was determined based on the sum of these scores. Descriptive statistics were used to describe the socio-demographic characteristics, while for analyzing grouped variables, Chi-squared test was run. Multivariate logistic regression test was also employed to adjust the effect of confounding variables.

Results: The mean score of sexual interest/desire among women was 30.6±10.5. After adjusting for the effect of confounding variables (socio-demographic variables such as age, age at first intercourse, level of education, etc.), logistic regression showed that age at first intercourse, length of marriage, and the level of satisfaction with income were significantly associated with both LSD and HSDD (P<0.01). In addition, advancing age (P<0.001) and body mass index (P<0.01) were predictors of LSD alone.
Conclusion: Some socio-demographic factors could predict LSD in women, while they were not associated with HSDD. In other words, some factors associated with LSD do not instigate personal distress, which is one of the criteria necessary for the diagnosis of HSDD.
Breastfeeding cessation in the era of Elimination of Mother to Child Transmission of HIV in Uganda: a retrospective cohort study
Authors: Ngbapai Jackslina Gaaniri , Izudi Jonathan , Okoboi Stephen 
Published: August 2020

Abstract
Background: Breastfeeding an infant exposed to HIV carries the risk of HIV acquisition whilst not breastfeeding poses higher risk of death from malnutrition, diarrhea, and pneumonia. In Uganda, mothers living with HIV are encouraged to discontinue breastfeeding at 12 months but data are limited. We examined the frequency and factors associated with cessation of breastfeeding at one year among mothers living with HIV at Ndejje Health Center IV, a large peri-urban health facility in Uganda.Methods: This retrospective cohort study involved all mothers living with HIV enrolled in HIV care for ≥12 months between June 2014 and June 2018. We abstracted data from registers, held focus group discussions with mothers living with HIV and key informant interviews with healthcare providers. Cessation of breastfeeding was defined as the proportion of mothers living with HIV who had discontinued breastfeeding at one year. We summarized quantitative data descriptively, tested differences in outcome using Chi-square and t-tests, and established independently associated factors using modified Poisson regression analysis at 5% statistical significance level. We thematically analyzed qualitative data to enrich and triangulate the quantitative results. Results: Of 235 participants, 150 (63.8%) had ceased breastfeeding at one year and this was independently associated with the infant being female (Adjusted risk ratio (aRR): 1.25, 95% confidence interval (CI), 1.04, 1.50), the mother being multiparous (aRR, 1.26; 95%CI, 1.04-1.53), and the initiation of breastfeeding being on the same-day as birth (aRR, 0.06; 95%CI, 0.01-0.41).The reasons for ceasing breastfeeding included male infants over breastfeed than females, maternal literacy and knowledge adequacy about breastfeeding, support and reminders from the partner, and boys can bite once they get teeth. Conversely, the reasons for not ceasing to breastfeed encompassed insufficient knowledge about breastfeeding and girls feed a bit less.Conclusion: Suboptimal proportion of infants were ceased from breastfeeding at one year and this might increase the risk of mother to child transmission of HIV. Cessation of breastfeeding was more likely among female infants and multiparous mothers but less likely when breastfeeding was initiated on same-day as birth. Interventions to enhance cessation of breastfeeding should target groups of mothers with lower rates.
Adherence to World Health Organisation guidelines for treatment of early onset neonatal sepsis in low-income settings; a cohort study in Nepal
Authors: Ekman Beatrice , Paudel Prajwal , Basnet Omkar , Ashish KC , Wrammert J. 
Published: August 2020

Abstract
Background

Neonatal sepsis is one of the major causes of death during the first month of life and early empirical treatment with injectable antibiotics is a life-saving intervention. Adherence to World Health Organisation guidelines on first line antibiotics is crucial to mitigate the risks of increased antimicrobial resistance. The aim of this paper was to evaluate if treatment of early onset neonatal sepsis in a low-income facility setting observe current guidelines and if compliance is influenced by contextual factors.

Methods

This cohort study used data on antimicrobial treatment of neonatal sepsis onset within 72 hours of life from 12 regional hospitals participating in a scale-up trial of a neonatal resuscitation quality improvement package intervention in Nepal. Infants treated according to guidelines were compared with those receiving other antimicrobials. A multiple logistic regression analysis adjusted for the intervention and time trend was applied.

Results

1,564 infants with a preliminary diagnosis of early onset sepsis were included. A majority (74.9%) were treated according to guidelines and adherence was increasing over time. Infants born at larger facilities (adjusted Odds Ratio 5.6), those that were inborn (adjusted Odds Ratio 1.97) or belonging to a family of dis-advantaged caste (adjusted Odds Ratio 2.15) had higher odds for treatment according to guidelines. A clinical presentation of lethargy or tachypnoea was associated with adherence to guidelines.

Conclusion

Adherence to guidelines for antibiotic treatment of early neonatal sepsis was moderately high in this low-income setting. Odds for observing guidelines increased with facility size, for inborn infants and if the family belonged to a dis-advantaged caste. Cefotaxime was a common alternative choice when guidelines were not followed, highly relevant for the risk of increased antimicrobial resistance.
Three-dimensional printing technology for localised thoracoscopic segmental resection for lung cancer : a quasi-randomised clinical trial
Authors: Chen Yangming , Zhang Jiguang , Chen Qianshun , Li Tian , Chen Kai , Yu Qinghua , Lin Xing 
Published: August 2020

Abstract
Background : Three-dimensional (3D) computed tomography (CT) reconstruction technology has gained increasing attention owing to its potential in locating ground glass nodules in the lung. The 3D printing technology additionally allows the visualisation of the surrounding anatomical structure and variations. However, the clinical utility of these techniques is unknown. This study aimed to establish a lung tumour and an ana tomical lung model using 3D printing and 3D chest CT reconstruction and to evaluate the clinical potential of 3D printing technology in uniportal video-assisted thoracoscopic segmentectomy . Methods : Eighty-nine patients with ground glass nodules who underwent uniportal video-assisted thoracoscopic segmentectomy were classified into the following groups: Group A, lung models for pre-positioning and simulated surgery that were made with 3D chest CT reconstruction and 3D printing; Group B, patients who underwent chest CT scans with image enhancement for 3D reconstruction. The differences in the surgery approach transfer rate, surgical method conversion rate, operative time, intraoperative blood loss, and postoperative complication rate were compared between the groups. Results : The surgery approach transfer rate was 0% and 10.5% for Groups A and B, respectively, showing a significant difference (p=0.030); the operative time was 2.07±0.24 hours and 2.55±0.41 hours, respectively, indicating a significant difference (p<＜0.001); intraoperative blood loss volume was 43.25±13.63 and 96.68±32.82 mL, respectively, demonstrating a significant difference (p<＜0.001); the postoperative complication rate was 3.9% and 13.2%, respectively, showing a non-significant difference (P=0.132). The rate of surgical method conversion to lobectomy in Group A was 0%, which was significantly lower than that of 10.5% in group B (p<0.030). Conclusions : 3D printing technology facilitates a more accurate location of nodules by surgeons, as it is based on two-dimensional and 3D imaging findings, thereby improving the accuracy and safety of surgery. This technique is worth applying in clinical practice.
Wild-type cutoff for Apramycin against Escherichia coli
Authors: Yang Yuqi , Xiao Tianshi , Li Jiarui , Cheng Ping , Li Fulei , Yu Hongxiao , Liu Ruimeng , Muhammad Ishfaq , Zhang Xiuying 
Published: August 2020

Abstract
Background：Apramycin is used exclusively for the treatment of Escherichia coli (E.coli) infections in swine around the world since the early 1980s. Recently, many research papers have demonstrated that apramycin has significant in vitro activity against multidrug-resistant E.coli isolated in hospitals. Therefore, ensuring the proper use of apramycin in veterinary clinics is of great significance of public health. The objectives of this study were to develop a wild-type cutoff for apramycin against E.coli using a statistical method recommended by Clinical and Laboratory Standards Institute (CLSI) and to investigate the prevalence of resistance genes that confer resistance to apramycin in E. coli.Results: Apramycin susceptibility testing of 1230 E.coli clinical isolates from swine were determinded by broth microdilution testing according to the CLSI document M07-A9. A total number of 310 E.coli strains from different minimum inhibitory concentration (MIC) subsets (0.5-256 µg/mL) were selected for the detection of resistance genes (aac(3)-IV; npmA; apmA) in E. coli by PCR. The percentage of E. coli isolates at each MIC (0.5, 1, 2, 4, 8, 16, 32, 64, 128, and 256 µg/mL) was 0.08%, 0.08%, 0.16%, 2.93%, 31.14%, 38.86%, 12.85%, 2.03%, 1.46%, and 10.41%. The MIC50 and MIC90 were 16 and 64 µg/mL. All the 310 E.coli isolates were negative for npmA and apmA gene, and only the aac(3)-IV gene was detected in this study.Conclusions: The wild-type cutoff for apramycin against E.coli was defined as 32 µg/mL. The prevelance of aac(3)-IV gene mainly concentrated in these MIC subsets ‘MIC ≥ 64 µg⁄ mL’, which indicates that the wild-type cutoff established in our study is reliable. The wild-type cutoff offers interpretion criteria of apramycin susceptibility testing of E.coli.
Factors associated with anxiety and depression in rheumatoid arthritis patients: A cross-sectional study
Authors: Uda Miyabi , Hashimoto Motomu , Uozumi Ryuji , Torii Mie , Fujii Takao , Tanaka Masao , Furu Moritoshi , Ito Hiromu , Terao Chikashi , Yamamoto Wataru , Sugihara Genichi , Nakagami Yukako , Mimori Tsuneyo , Nin Kazuko 
Published: August 2020

Abstract
Background Management of anxiety and depressive symptoms in rheumatoid arthritis (RA) patients is vital. Previous studies investigating this topic are conflicting, and this topic still has not been thoroughly investigated. This study aimed to clarify the association of disease activity with anxiety and depressive symptoms after controlling for physical disability, pain, and treatment.Methods We conducted a cross-sectional study of RA patients from the Kyoto University Rheumatoid Arthritis Management Alliance cohort. For assessments, we used the Disease Activity Score (DAS28), Health Assessment Questionnaire Disability Index (HAQ-DI), and Hospital Anxiety Depression Scale. Depression and anxiety were defined by a Hospital Anxiety Depression Scale score ≥8. We then performed multivariable logistic regression analyses.Results Of 517 participants, 17.9% had anxiety and 28.2% had depression. The multivariable logistic regression analyses showed that DAS28-based non-remission was not statistically associated with anxiety symptoms (odds ratio [OR] [95% confidence interval {CI}], 0.93 [0.48–1.78]: p = 0.82) and depressive symptoms (OR [95% CI], 1.45 [0.81–2.61]: p = 0.22). However, severity of the patient’s global assessment (PtGA) on DAS28 was associated with anxiety symptoms (OR [95% CI], 1.15 [1.02–1.29]; p = 0.03) and depressive symptoms (OR [95% CI], 1.21 [1.09–1.35]; p < 0.01). Additionally, HAQ-DI-based non-remission was associated with anxiety symptoms (OR [95% CI], 3.51 [1.85–6.64]; p < 0.01) and depressive symptoms (OR [95% CI], 2.65 [1.56–4.50]; p < 0.01). Patients using steroids had a closer association with depressive symptoms than those not using them (OR [95% CI], 1.66 [1.03–2.67]; p = 0.04).Conclusions As per the multivariable logistic regression analysis, there was no association between DAS28-based-non-remission and anxiety and depressive symptoms; however, the univariate analysis revealed such association. In the multivariate analysis, PtGA and non-remission on HAQ were associated with anxiety and depressive symptoms. Rather than focusing solely on controlling disease, activity and treatment should focus on improving or preserving physical function and patient's overall sense of well-being.
Combined support mechanism of rock bolt and anchor cable for adjacent roadways in the external staggered split-level panel layout
Authors: Batugin Adrian , Wang Zhiqiang , Lv Wenyu , Su Zehua , Sidikovna Shermatova Sayyora 
Published: August 2020

Abstract
Utilizing the spatial structure characteristic of the external staggered split-level panel layout, the combined support technology of adjacent roadways was proposed, and combined support mechanism of rock bolt and anchor cable was analyzed. The influence of side rock bolt and anchor cable parameters respectively on mechanical properties of the anchorage body and support stress distribution of lateral coal body were revealed through FLAC 3D software. The optimal support parameters of side rock bolt and anchor cable were determined subsequently. And the support effect of the gob-side entry under mining influence was verified. Result shows that the support of side rock bolt and anchor cable can improve mechanical properties and the stress state of the anchorage body, which has a good protective effect on the coal body of the air-intake entry roof and side wall. It is beneficial to the stability of the side wall and the realization of the suspension effect for the roof rock bolt and anchor cable, which makes the surrounding rock maintenance of the gob-side entry of the thick coal seam more favorable.
Is it the time to implement the routine use of distress thermometer among Egyptian patients with newly diagnosed cancer?
Authors: Aziz Nashwa Abd El- , Khallaf Salah , Abozaid Waleed , Elgohary Ghada , El-Fattah Ola Abd , Elhawary Mai , Khaled Safaa , El-Haffez Azza Abd , Kamel Ehab , Mohamed Sherif 
Published: August 2020

Abstract
Background: The distress thermometer (DT) is an effective tool for identifying distress among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of distress among Egyptian patients with different types of cancers using DT.Methods: A total of 550 patients with newly diagnosed hematological and solid cancers who were followed up at 3 Oncology Centers in Egypt were enrolled. They completed a sociodemographic and clinical status questionnaire, the DT and the Problem List (PL) scale.Results: At a DT cut-off score of ≥4, 46% of patients had significant distress, which was related to the tumor site and stage. The most frequent problems reported were treatment decision (64.4%), worry (47%), and fears (44.5%). In univariate logistic regression analysis, participants who had significant distress described 23 out of 36 problems in the practical, family, emotional, and physical areas. After adjustment to sociodemographic and clinical characteristics, multivariable analysis confirmed that insurance, depression, fear, sadness, worry, loss of interest in usual activity, and sleep were independent factors associated with significant distress in cancer patientsConclusions: Almost half of Egyptian patients newly diagnosed with cancer reported significant distress. Those who had significant distress described extra problems in the practical, family, emotional, and physical areas. We recommend the routine use of DT for screening Egyptian patients with cancer, as well as the involvement of the psycho-oncology and social services, at the time of their initial diagnosis.
Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure
Authors: YANG MEI , Li Xuping , III John C. Morris , Liang Jinjun , Deshmukh Abhishek J. , Hodge David , Li Yi-Gang , Cha Yong-Mei 
Published: August 2020

Abstract
Background Hypothyroidism is known to be associated with adverse clinical outcomes in heart failure. The association between hypothyroidism and cardiac resynchronization therapy outcomes in patients with severe heart failure is not clear. Methods The study included 1,316 patients who received cardiac resynchronization therapy between 2002 and 2015. Baseline demographics and cardiac resynchronization therapy outcomes, including left ventricular ejection fraction, New York Heart Association class, appropriate implantable cardioverter-defibrillator therapy, and all-cause mortality, were collected from the electronic health record. Results Of the study cohort, 350 patients (26.6%) were classified as the hypothyroidism group. The median duration of follow-up was 3.6 years (interquartile range, 1.7-6.2). Hypothyroidism was not associated with a higher risk of all-cause mortality in patients receiving CRT for heart failure. The risk of appropriate implantable cardioverter-defibrillator therapy significantly increased in association with increased baseline thyroid -stimulating hormone level in the entire cohort (hazard ratio, 1.23 per 5mIU/L increase; 95% CI, 1.01-1.5; P=0.04) as well as in the hypothyroid group (hazard ratio, 1.44 per 5mIU/L increase; 95% CI, 1.13-1.84; P=0.004). Conclusions CRT improves cardiac function in hypothyroid patients. The ventricular arrhythmic events requiring ICD therapies are associated with baseline TSH level, which might be considered as an important biomarker to stratify the risk of sudden death for patients with heart failure and hypothyroidism.