bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline characteristics of hypertensive patients with descending thoracic or abdominal aortic aneurysm referred for endovascular treatment
Authors: Gurevich A. P. , Ionov M. V. , Emelianov I. V. , Vanyurkin A. G. , Panteleeva Yu. K. , Chernov A. V. , Chernyavsky M. A. , Konradi A. O. 
Published: December 2024

Aim. To analyze perioperative characteristics, including central hemodynamic parameters, of patients with hypertension (HTN) and descending thoracic aortic aneurysm (TAA) or abdominal aortic aneurysm (AAA) who were referred for endovascular aortic repair ([T]EVAR).Material and methods. Local registry data were used. The study included 126 patients (103 men, 67±9 years). In addition to the basic examination, noninvasive measurement of central blood pressure (BP) and carotid-femoral pulse wave velocity (cfPWV) was performed. Quality of life (QOL) was assessed using the EQ-5D-3L questionnaire.Results. The most common comorbidities were coronary artery disease (68%), obesity (39%), chronic kidney disease (26%), and type 2 diabetes (18%). Patients with AAA were significantly older and had a higher comorbidity burden, but had a better QOL than patients with TAA (59% vs 71%, p<0,05. High medication adherence was noted in 31% of patients receiving an average of 2 antihypertensive drugs and 59% of them had controlled HTN. Carotid-femoral PWV was higher (10,9 vs 9,6 m/s, p=0,006) and augmentation index (AIx) was lower in TAA (21% vs 29%, p<0,001). Large aneurysm size was associated with lower cfPWV and increased central diastolic BP (p=0,01 and p=0,03, respectively). Increased central pulse pressure (CPP) was positively associated with left ventricular mass index (r=0,21, p=0,037). A decrease in CPP and AIx was observed after [T]EVAR.Conclusion. Patients with HTN and TAA/AAA referred for [T]EVAR have a high comorbidity burden and high QOL. Although the vast majority of patients receive a combination of only two drugs, insufficient adherence to therapy has been revealed. An increase in aneurysm diameter is associated with a decrease in cfPWV and increased central diastolic BP, indicating a potential impact of aneurysm on central hemodynamics in patients receiving antihypertensive therapy.
Comparison of cardiac morphological and functional changes according to magnetic resonance imaging with the genetic testing data in patients with hypertrophic cardiomyopathy
Authors: Gagarina E. V. , Mershina E. A. , Chumakova O. S. , Myasnikov R. P. , Kulikova O. V. , Kudryavtseva M. M. , Sinitsyn V. E. 
Published: December 2024

Aim. To analyze the data of cardiac magnetic resonance imaging (MRI) of patients with hypertrophic cardiomyopathy (HCM) depending on the results of genetic testing.Material and methods. The study included 83 patients with a diagnosis of HCM (39 men, 44 women, mean age 50,4±14,9 years) who had no contraindications to MRI. Cardiac MRI was performed on 1,5 T and 3 T MRI systems using a standard protocol. T1 and T2 mapping was performed in 41 patients, and the extracellular volume fraction was estimated. All patients underwent genetic testing with assessment of sarcomeric genes, two non-sarcomeric genes associated with HCM, and genes of syndromic diseases (HCM phenocopies).Results. Positive results of genetic testing were obtained in 49 (59%) of 83 patients: MYBPC3 29%, MYH7 17%, TPM1 5%, FLNC 4%, MYL2 2%, TNNC1 1%, TNNI3 1% (genotype-positive group (G+)). Negative results of genetic testing were obtained in 34 (41%) patients (genotype-negative group (G-)). In the G-group, patients were significantly older than in G+ (57,7±12,9 vs 45,3±14,2 years, p<0,05), with a smaller left ventricular (LV) wall thickness (18,9±4,2 vs 21,3±5,9 mm, p<0,05), and a higher LV ejection fraction (70,5±10,7 vs 64,7±10,4%, p<0,05). Comparison of myocardial fibrosis parameters between the groups showed a significantly lower incidence of delayed contrast enhancement in the G-group, and in its presence, the fibrosis severity, which was assessed as the fibrosis percentage from the total LV mass, was significantly lower than in the G+ group (71% vs 92%; 5,0±8,0% vs 11,4±9,0%, respectively, p<0,05). When analyzing G+ patients depending on the identified mutations, no significant difference in the severity of fibrosis was found between the groups.Conclusion. In patients with HCM, a positive genetic analysis, regardless of the affected gene, is associated with a greater severity of fibrosis according to MRI data, which indicates a less favorable prognosis.
Development of predictive models for differential diagnosis of hypertrophic cardiomyopathy
Authors: Zaitsev V. V. , Safronov K. S. , Konasov K. S. , Bavshin T. R. , Manokhin K. A. , Obraztsova L. A. , Moiseeva O. M. 
Published: December 2024

Aim. To develop predictive models for differential diagnostics of hypertrophic phenotype in patients with concomitant diseases, as well as to validate through independent assessment.Material and methods. The study included an analysis of 1169 medical records from the medical information system of patients with severe myocardial hypertrophy and a preliminary diagnosis of hypertrophic cardiomyopathy (HCM) (I42.1, I42.2). The patients were divided into 3 following groups: patients with a probable HCM, patients with moderate myocardial hypertrophy (>15 mm) due to a known disease, and patients with severe myocardial hypertrophy that cannot be explained by left ventricular pressure overload ("gray zone"). The original dataset contains 74 parameters. Machine learning models of the following classes were created and optimized: logistic regression, support vector machine, decision tree, and gradient boosting decision trees.Results. All models have sufficient accuracy in detecting HCM, but the accuracy of ruling out the diagnosis is quite low. The use of a machine learning model using logistic regression reduced the HCM misdiagnosis risk in the group of questionable diagnosis to 31%.Conclusion. Four predictive models for differential diagnosis of severe left ventricular myocardial hypertrophy were developed to improve the HCM diagnosis. Blinding validation showed that logistic regression is the most optimal model for clinical practice.
2024 Clinical practice guidelines for Chronic heart failure
Authors: Galyavich A. S. , Tereshchenko S. N. , Uskach T. M. , Ageev F. T. , Aronov D. M. , Arutyunov G. P. , Begrambekova Yu. L. , Belenkov Yu. N. , Boytsov S. A. , Bubnova M. G. , Vasyuk Yu. A. , Villevalde S. V. , Vinogradova N. G. , Garganeeva A. A. , Gendlin G. E. , Gilyarevsky S. R. , Glezer M. G. , Gautier S. V. , Grinstein Yu. I. , Dovzhenko T. V. , Drapkina O. M. , Duplyakov D. V. , Zhirov I. V. , Zateishchikov D. A. , Zvartau N. E. , Irtyuga O. B. , Kobalava Zh. D. , Koziolova N. A. , Koroteev A. V. , Libis R. A. , Lopatin Yu. M. , Mareev V. Yu. , Mareev Yu. V. , Matskeplishvili S. T. , Mikhailov E. N. , Nasonova S. N. , Narusov O. Yu. , Nedogoda S. V. , Nedoshivin A. O. , Ovchinnikov A. G. , Orlova Ya. A. , Perepech N. B. , Pogosova N. V. , Rimskaya E. M. , Samko A. N. , Saidova M. A. , Sapelnikov O. V. , Safiullina A. A. , Sitnikova M. Yu. , Skvortsov A. A. , Skibitskiy V. V. , Stukalova O. V. , Tarlovskaya E. I. , Tereshchenko A. S. , Chesnikova A. I. , Fedotov P. A. , Fomin I. V. , Khasanov N. R. , Shevchenko A. O. , Shaposhnik I. I. , Shariya M. A. , Shlyakhto E. V. , Yavelov I. S. , Yakushin S. S. 
Published: December 2024

Russian Society of Cardiology (RSC)With the participation: National Society of Myocardial Diseases and Heart Failure, Society of Heart Failure Specialists, Russian Scientific Medical Society of Internal MedicineEndorsed by the Research and Practical Council of the Ministry of Health of the Russian Federation (12.09.2024)
Vibrotactile perception depends on cognition not just peripheral nerve integrity: a cross-sectional study
Authors: Robbins Nathaniel , Bujarski Krzysztof , Stark Aleksandra , Palladino Thomas , Bursey Julie , Mason Stephen , Stommel Elijah , Lawson Victoria 
Published: December 2024

Background: Vibration perception is often considered a peripheral nerve and dorsal column function, without considering the role of cognition. The current study tested cognition’s role in vibrotactile perception thresholds (VPT).
Methods: We recruited cases with mild-moderate dementia or mild cognitive impairment thought to reflect probable Alzheimer’s pathology (AD/MCI group), and controls without memory concerns (all participants >50 years). Polyneuropathy, B12 deficiency, diabetes, or other conditions associated with cognitive impairment were exclusionary criteria. Participants underwent cognitive evaluation with the Self-Administered Gerocognitive Examination (SAGE), standardized nerve conduction studies, and quantitative VPT testing. Demographic and medical history were obtained through interview and chart review. We constructed linear regression models to test whether poor cognition correlates with VPT.
Results: Nineteen AD/MCI participants (age 71.5±8.9, 47.4% female) and fourteen controls (age 67.4±9.3, 78.6% female) did not differ on age or gender. Univariate predictors of poor/increased mean VPT (all p­-values <0.10) were age, AD/MCI, SAGE score, sural sensory nerve action potential (SNAP) amplitude <5 microvolts, yearly income <$50,000, history of vascular disease, and peroneal motor and sural conduction velocity (CV). SAGE score (standardized β=-0.38, p<0.01); sural SNAP amplitude (β=0.51, p<0.001); peroneal motor CV (β=-0.37, p<0.01), history of vascular disease (β=0.27, p=0.03), and female gender (β=0.22, p=0.10) remained independently associated with VPT in multivariable linear regression analysis (backwards modeling; removal criteria p>0.10; model adjusted R2=0.66; p<0.001).
Conclusions: Poor cognition is associated with worsened VPT. Neurologists should consider cognition when using sensory perception to assess peripheral nerve integrity, both for research and during a traditional neurologic examination.
RelaRelación entre Burnout y las competencias digitales en el proceso de enseñanza-aprendizaje de los docentes universitarios peruanos durante la pandemia COVID-19
Authors: Pérez Narrea Julio César , Mendoza-García Erica , Guevara Ingelmo Raquel María , Moral-García José Enrique 
Published: December 2024

La pandemia COVID-19 ha generado un impacto de gran relevancia en la educación superior de todo el mundo. En Perú, la situación de confinamiento vivida durante el estado de alarma supuso la suspensión de las clases presenciales y un proceso de adaptación a una realidad educativa que hizo que millones de personas continuaran con su formación desde casa. Esto significó un verdadero reto para el profesorado universitario, que, ante un modelo de educación a distancia de emergencia, tuvo que acomodarse a una modalidad docente compleja con diversas opciones tecnológicas y pedagógicas sin precedentes. Este fenómeno hizo desencadenó o aumentó el estrés conocido como Burnout del docente. El presente estudio de tipo transversal, descriptivo mediante encuesta, analizó el impacto del burnout sobre la competencia digital y su relación con factores sociodemográficos en docentes universitarios peruanos. Participaron 274 docentes (105 mujeres, 169 varones). Los resultados mostraron relación significativa entre el Burnout y las Competencias Digitales, así experimentaron mayor Burnout presentaron menor competencia digital. Por otro lado, existe diferencia significativa según los años de experiencia en la docencia, teniendo un mayor nivel de competencia digital en la dimensión pedagógica, y en la dimensión de despersonalización y falta de realización personal de Burnout.
Inteligência artificial na educaçao: Análise dos últimos 5 anos.
Authors: Domingos Mariane , De Souza Vanessa Maria , Vizconde Veraszto Estéfano 
Published: December 2024

Este artigo analisa o papel da inteligência artificial (IA) na educação nos últimos cinco anos, a partir de uma análise bibliométrica de publicações indexadas na Web of Science. A busca retornou com 307 artigos, aos quais foram analisadas e levantadas as similaridades entre a IA na educação, evidenciando países em destaque e palavras chaves, considerando a correlação entre autores e fatores. A partir dos resultados desta busca, foi possível identificar os principais temas relacionados ao objetivo inicial da pesquisa. A pesquisa mostrou as tendências no uso de IA destacando a crescente importância de tecnologias como aprendizado de máquina e redes neurais na personalização do ensino. Os dados indicam o impacto da IA em diversos países e como ela pode contribuir para o aprimoramento da educação.
Objeto de conocimiento en la formación de los docentes de la Unidad Profesional Interdisciplinaria de Ingeniería de Guanajuato (UPIIG)
Authors: Murillo Yañez Luis Enrique , Camargo Cíntora Eréndira , Hurtado Rangel Ricardo 
Published: December 2024

El trabajo de investigación muestra el análisis de la lectura de la realidad que se obtiene del campo problemático y campo de objetos de conocimientos del paradigma dialéctico transdisciplinaria; los elementos que se generan de los contextos de niveles micro, meso y macro aportan a la conceptualización del objeto de conocimiento que atenderá los rasgos del sujeto que se propusieron por Murillo & Camargo (2022) para la formación de formadores de docentes de nivel superior de la Unidad Profesional Interdisciplinaria de Ingeniería campus Guanajuato.
Se conceptualiza el campo problemático y campo de objetos de conocimiento con base en el enfoque del pensamiento complejo y transdisciplina. En el análisis de la lectura de realidad de los países de Alemania, Japón, Finlandia, China y México con contextos y estructuras de formación de nivel superior se obtuvieron componentes y conceptos que permite construir el campo de objetos de conocimiento y el objeto de conocimiento posible para la formación de formadores.
El objeto de conocimiento orientado a la formación de formadores para docentes de nivel superior en el área de ingeniería atendiendo rasgos del sujeto que fortalezcan la calidad docente desde diferentes estructuras y la práctica docente que permita atender algunos desafíos de los contextos locales, como la escuela, institución, comunidad, así como, contextos meso, el municipio, estado y el país; para construir una sociedad que elimine problemas y desigualdad sociales.
Experiences of Physiotherapy and Occupational Therapy Undergraduates and Placement Educators of Blended Practice-Based Learning
Authors: Orton Helen , Deaves Amanda , Barnes-Brown Vikki , Edge Christopher , Rees Anna , Prescott Denise 
Published: December 2024

Securing sufficient practice-based learning opportunities for health care students is long-standing and well documented and not unique to the United Kingdom (Beveridge & Pentland 2020; Martin et al., 2004). Increasing Allied Health Professional learners on healthcare programmes and the COVID-19 pandemic have highlighted the need for radical change and innovative ways of working to address placement capacity. Due to the capacity pressures, blended practice-based placements were implemented in partnership with clinical collaboration across the Cheshire and Merseyside region. As this placement model had not been robustly tested, a decision was made to pilot this across different settings and ethical approval was sought and granted, to fully evaluate this approach. The participants consisted of second-year physiotherapy and first- and second-year occupational therapy learners. The aims of the study were to: ascertain the value and experiences of a newly introduced blended placement-based learning through the anonymous collection of data from an online questionnaire (quantitative) and focus groups (qualitative) in response to challenges relating to placement capacity.
Initial findings suggest there are benefits for learners including new skill acquisition, such as organisational and adaptability skills, the ability to influence change in patient care and improved clinical reasoning. Challenges for learners include the type and length of project not being comparable to their peers, reduced clinical time, perceived discrepancies in marking during the placement and opportunities to develop confidence. Alternative placement models are required to meet ongoing capacity demands. This work adds to the growing body of placement related literature.
Avaliação das características morfológicas e físico-químicas do mesocarpo da Attalea phalerata do estado de Mato-Grosso
Authors: Spada Elaine Cristina de Lara , Boaventura Mariana Favero , Souza Geferson Andrade de , Hernandes Thais , Lemes Suélem Aparecida de França 
Published: December 2024

O acuri (Attalea phalerata Mart. ex Spreng) é uma palmeira de grande ocorrência no Pantanal e outras regiões brasileiras. Estudos demonstram que sua polpa é rica em óleo e carotenoides, precursores de vitamina A. Existem poucos estudos da polpa do acuri para fins alimentícios, quer como pró-vitamina A, ou corante em substituição ao β-caroteno sintético, embora os óleos vegetais ricos em antioxidantes estejam sendo amplamente estudados pela indústria farmacêutica e alimentícia. A estabilidade do óleo é um dos primeiros fatores que garantem a qualidade do produto, assim, o objetivo deste estudo foi caracterizar a morfologia do fruto, a extração do óleo e avaliar a qualidade físico-química. Os frutos foram coletados em Várzea Grande-MT e exsicata depositada no herbário da Universidade Federal de Mato Grosso (UFMT) (44310). Os frutos foram higienizados, despolpados, secos em estufa por circulação de ar a 40°C por 30h. O óleo foi obtido por extração sólido-liquido com hexano (1:3) durante 7 dias. Posteriormente, rotaevaporado e armazenado em frasco âmbar. Foram determinados em triplicata análises de índice de acidez, teores de ácidos graxos livres (AGL), índice de peróxidos e densidade relativa, segundo métodos do Instituto Adolf Lutz. O rendimento do óleo foi de 11,39%, apresentou acidez de 8,62 ± 0,57 mg NaOH/g (até 10,0mgNaOH/g), teor de AGL de 0,43% ± 0,01 de ácido oleico, índice de peróxidos de 0,99 ± 1,20mEq/kg (máximo 20mEq/kg) e densidade de 0,79 ± 0,01g/ml. O fruto da Attalea phalerata possui morfologia condizente com sua espécie e o óleo do seu mesocarpo apresentou estabilidade oxidativa, estando dentro dos padrões de identidade e qualidade estabelecidos pela legislação vigente para óleo vegetal.
Conforto térmico e ambiente urbano: avaliação preliminar no Conjunto Paulo VI, Belo Horizonte, MG
Authors: Assis Eleonora Sad de , Hirashima Simone Queiroz da Silveira 
Published: December 2024

Áreas urbanas informais e densamente construídas na cidade de Belo Horizonte, Minas Gerais, Brasil tendem a ficar mais quentes do que a cidade formal e podem apresentar condições de desconforto térmico durante todo o ano. Considerando a escassez de estudos nestas áreas, apresenta-se o caso do Conjunto Paulo VI, localizado em Belo Horizonte, com o objetivo de avaliar as condições de conforto térmico no horário mais quente de um dia de inverno. Dados microclimáticos foram levantados em 25 pontos da área e inseridos no programa Rayman PRO, que foi configurado com as características do entorno de cada ponto e da população aclimatada, para cálculo do índice de conforto térmico Temperatura Equivalente Fisiológica (PET). Os resultados mostram que as condições de desconforto térmico nesta área estão relacionadas sobretudo à incidência solar nos recintos urbanos, sendo que as características construtivas da área acabam provocando altas temperaturas de superfície e radiante média. Considerando que a temperatura radiante média é uma variável microclimática que muito influencia o cálculo do PET, em dias ensolarados e de baixas velocidade do vento, medidas que possibilitem sua redução podem auxiliar na concepção de ambientes com condições térmicas mais favoráveis, diminuindo o desconforto térmico na área de estudo. Isto sugere que o sombreamento das áreas públicas pode ser a principal estratégia local para aumentar a resiliência do ambiente urbano à tendência de aquecimento e ao desconforto térmico.
Response of Onion (Allium cepa L.) Bulb to the Combined Effect of Vermicompost and Mineral Fertilizer under Irrigated Soil Condition in Raya Azobo and Kilte-Awulaelo Districts South and Eastern Tigray, Ethiopia
Authors: Teklehaimanot Tesfay , Zerfu Ambachew , Shumuye Meresa 
Published: December 2024

Background: In Ethiopia, onion (Allium Cepa L.) is a major vegetable crop. However, due to erratic cultivation, rising mineral fertilizer prices and inadequate soil fertility management, its productivity is declining. Integrated nutrient management is a cost-effective approach to fertilizing soil. If used properly, the combination of vermicomposting with mineral fertilizers is one of the most promising options. Nonetheless, in the study areas, the appropriate application rate of vermicompost and NPSZn fertilizer on onion production has not been well examined. Methods: A field experiment was conducted in the irrigated soil conditions of Kilte-Awulaelo and Raya Azobo districts. The study used a randomized complete block design with three replications and twelve experimental treatments (4.5, 3 and 1.5 t ha-1 vermicompost rates combined with NPSZn 75, 50 and 25 kg ha-1). Full recommended 6 t ha-1 vermicompost, 100 kg ha-1 NPSZn fertilizer and absolute control were used. The collected agronomic data were subjected to ANOVA using SAS statistical software (SAS 9.0) and mean separation was done using LSD. Result: Most of the measured onion growth and yield parameters were significantly affected by the joint application of vermicompost and NPSZn. It varies among districts. Maximum bulb yields of 51.2 t ha-1 in Kilte-Awulaelo and 42.5 t ha-1 in Raya Azobo district were obtained from the application of 4.5 t ha-1 vermicompost with 50 kg ha-1 NPSZn and 4.5 t ha-1 vermicompost with 75 kg ha-1 NPSZn respectively. The combined application of vermicompost with NPSZn fertilizer enhanced onion growth and yield.
Escritos de artistas e suas singularidades literárias
Authors: Franca-Huchet Patricia 
Published: December 2024

Aborda-se neste artigo um exercício de leitura sobre o texto do estadunidense Allan Kaprow, The real experimentation, no qual problematiza o que vem a ser a arte que se parece com a arte, em contraponto à arte que se parece com a vida. Para argumentar a diferença entre as duas propostas, Kaprow conta duas histórias para exemplificar sua tese, instigando o leitor e o artista a observar mais, andar mais, performar mais e se libertar através de caminhos que se orientam para se distanciar da comunidade tradicional das belas artes, assim como das comunidades das artes comerciais. O texto do artista é analisado em sua forma enunciativa e poética, nos iluminando não pelo fato de aceder à literatura com um grande L, mas pelo fato que restitui as percepções infinitesimais dos processos e visões, salvando o que está muitas vezes perdido e restituindo o saber singular; a argumentação de novos fenômenos.