bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing Monotone Likelihood in Duration Modelling of Political Events
Authors: Anderson Noel , Bagozzi Benjamin E. , Koren Ore 
Published: June 2020

AbstractThis article provides an accessible introduction to the phenomenon of monotone likelihood in duration modeling of political events. Monotone likelihood arises when covariate values are monotonic when ordered according to failure time, causing parameter estimates to diverge toward infinity. Within political science duration model applications, this problem leads to misinterpretation, model misspecification and omitted variable biases, among other issues. Using a combination of mathematical exposition, Monte Carlo simulations and empirical applications, this article illustrates the advantages of Firth's penalized maximum-likelihood estimation in resolving the methodological complications underlying monotone likelihood. The results identify the conditions under which monotone likelihood is most acute and provide guidance for political scientists applying duration modeling techniques in their empirical research.
Deformed wing virus type a and b in managed honeybee colonies of Argentina
Authors: Brasesco C. , Quintana S. , Di Gerónimo V. , Genchi García M. L. , Sguazza G. , Bravi M. E. , Fargnoli L. , Reynaldi F. J. , Eguaras M. , Maggi M. 
Published: June 2020

AbstractApis mellifera is infected by more than 24 virus species worldwide, mainly positive-sense, single-stranded RNA viruses of the Dicistroviridae and Iflaviridae families. Among the viruses that infect honey bees, Deformed wing virus is the most prevalent and is present as three master variants DWV-A, B, and C. Given that the ectoparasitic mite Varroa destructor vectors these virus variants, recombination events between them are expected, and variants and their recombinants can co-exist in mites and honeybees at the same time. In this study, we detect, through RT-qPCR, the presence of DWV-A and B in the same samples of adult bees from colonies of Argentina. Total RNA was extracted from pools of ten adult bees from 45 apiaries distributed across the main beekeeping Provinces of Argentina (Buenos Aires, Santa Fe, Córdoba, Santiago del Estero, Río Negro, and Mendoza); then RT-qPCR reactions were performed to detect DWV-A and B, with specific primer pairs. After the amplifications, PCR products (204 and 660 bp amplicons for DWV-B, and ~250 bp for DWV-A) were purified and sequenced to verify that they corresponded to reported sequences, analyzing them using the Blast software. Of the 45 samples analyzed by RT-qPCR, over 90% were infected with DWV-A and 47% were also positive for DWV-B, where it was found in high prevalence specifically in colonies of A. mellifera of the Buenos Aires Province. Future studies will determine the impact of this type of the virus and its ability to recombine with the other DWV types in the apiaries of our country.
Caravan Trade to Neoliberal Spaces: Fifty years of Pakistan-China connectivity across the Karakoram Mountains
Authors: KARRAR HASAN H. 
Published: June 2020

AbstractLocated along Pakistan's central Asian margins, the high mountain region of Gilgit-Baltistan borders Afghanistan and India, and since 1969 has connected Pakistan to China. In this article, I argue that over the last 50 years, expanding forms of connectivity between Pakistan and China were localized in Gilgit-Baltistan through three processes: (1) from 1969, overland connectivity between Gilgit-Baltistan and western China has enabled Pakistan to imagine and project expansive ties—and geopolitical aspirations—that transcend the border areas where the cross-border trade was initially localized; (2) unfolding ties between the two countries were accompanied by new material exchanges: initially barter trade and regulated caravans, followed by private commerce in the mid-1980s and, finally, economic corridor development under the Belt and Road Initiative; and (3) Chinese investments in Pakistan were part of a new cycle of global accumulation. Concurrently, in the wake of transnational investments, local governance in Gilgit-Baltistan adopted neoliberal administrative measures: the prioritizing of investment capitalism, the privatization of public goods and services, and securitization.
Association of parental substance misuse with offspring substance misuse and criminality: a genetically informed register-based study
Authors: Latvala Antti , Kuja-Halkola Ralf , D'Onofrio Brian M. , Jayaram-Lindström Nitya , Larsson Henrik , Lichtenstein Paul 
Published: June 2020

AbstractBackgroundGenetically informed studies have provided mixed findings as to what extent parental substance misuse is associated with offspring substance misuse and antisocial behavior due to shared environmental and genetic factors.MethodsWe linked data from nationwide registries for a cohort of 2 476 198 offspring born in Sweden 1958–1995 and their parents. Substance misuse was defined as International Classification of Diseases diagnoses of alcohol/drug use disorders or alcohol/drug-related criminal convictions. Quantitative genetic offspring-of-siblings analyses in offspring of monozygotic and dizygotic twin, full-sibling, and half-sibling parents were conducted.ResultsBoth maternal and paternal substance misuse were robustly associated with offspring substance misuse [maternal adjusted hazard ratio (aHR) = 1.83 (95% confidence interval (CI) 1.80–1.87); paternal aHR = 1.96 (1.94–1.98)] and criminal convictions [maternal aHR = 1.56 (1.54–1.58); paternal aHR = 1.66 (1.64–1.67)]. Additive genetic effects explained 42% (95% CI 25–56%) and 46% (36–55%) of the variance in maternal and paternal substance misuse, respectively, and between 36 and 44% of the variance in substance misuse and criminality in offspring. The associations between parental substance misuse and offspring outcomes were mostly due to additive genetic effects, which explained 54–85% of the parent-offspring covariance. However, both nuclear and extended family environmental factors also contributed to the associations, especially with offspring substance misuse.ConclusionsOur findings from a large offspring-of-siblings study indicate that shared genetic influences mostly explain the associations between parental substance misuse and both offspring substance misuse and criminality, but we also found evidence for the contribution of environmental factors shared by members of nuclear and extended families.
The COVID-19 Pandemic: A Month of Bioethics in Finland—ADDENDUM
Authors: HÄYRY MATTI 
Published: June 2020

AbstractThe role of bioethicists amidst crises like the COVID-19 pandemic is not well defined. As professionals in the field, they should respond, but how? The observation of the early days of pandemic confinement in Finland showed that moral philosophers with limited experience in bioethics tended to apply their favorite theories to public decisions with varying results. Medical ethicists were more likely to lend support to the public authorities by soothing or descriptive accounts of the solutions assumed. These are approaches that Tuija Takala has called the firefighting and window dressing models of bioethics. Human rights lawyers drew attention to the flaws of the government’s regulative thinking. Critical bioethicists offered analyses of the arguments presented and the moral and political theories that could be used as the basis of good and acceptable decisions.
Unconventional deployment of atrial septal occluder in a patient with atrial septal defect, dextrocardia, and interrupted inferior vena cava
Authors: Yerram Sreekanth , Aramalla Sunitha , Bhyravavajhala Srinivas 
Published: June 2020

AbstractAn atrial septal defect is a rare anomaly in patients with interrupted inferior vena cava, which renders the percutaneous intervention more complex; and hence, innovative approaches should be sought. Dextrocardia further complicates the procedure, and traditional atrial septal device deployment methods cannot be employed. We report a successful percutaneous secundum atrial septal defect closure by a novel deployment strategy along with balloon dilation of associated severe valvular pulmonary stenosis in a patient with dextrocardia and interrupted inferior vena cava.
Healthcare utilization among breast cancer patients during the COVID-19 outbreak
Authors: Shinan-Altman Shiri , Levkovich Inbar , Tavori Guy 
Published: June 2020

AbstractObjectiveContinuing to utilize healthcare as needed during an epidemic outbreak is significant, in general, and especially for cancer patients. Therefore, this study aimed to explore factors associated with health services utilization among breast cancer patients during the coronavirus disease (COVID-19) outbreak.MethodA cross-sectional online survey was conducted among 151 women with breast cancer. Participants completed measures of perceived health status, perceived susceptibility to COVID-19, anxiety, coping resources, health services utilization (contact with healthcare professionals and cancellation of an appointment to the oncology/hematology clinic), and socio-demographic questionnaires. A multiple hierarchical regression was calculated; contact with healthcare professionals was the dependent variable. In addition, a logistic regression was calculated; cancellation of an appointment to the oncology/hematology clinic because of the COVID-19 was the dependent variable.ResultsBreast cancer patients’ contact with healthcare professionals was lower than their contact prior to the pandemic. A higher extent of contact with healthcare professionals was related to patients’ perception of health as bad/reasonable, lower perceived susceptibility, a lower sense of mastery, and higher social support. In addition, the odds of cancelling an appointment to the oncology/hematology clinic were higher in the presence of additional chronic illnesses and a higher sense of mastery.Significance of resultsThe results could provide public health agencies with a more complete picture of the impact of the COVID-19 epidemic among breast cancer patients. This is significant because, in the event that COVID-19 re-emerges, the findings of the current study could help guide public health officials and possibly prevent the future avoidance of health services’ use among this high-risk population.
Analysis of load mismatch effect compensation in Doherty power amplifier
Authors: Courty Alexis , Medrel Pierre , Reveyrand Tibault , Bouysse Philippe , Nébus Jean-Michel , Soubercaze-Pun Geoffroy 
Published: June 2020

AbstractThis paper presents a theoretical and experimental analysis of the capabilities of the dual-input Doherty power amplifier (DPA) architecture to mitigate efficiency and output power degradations when used in a mismatched load environment. Following a simplified linear piecewise approach, an analytical demonstration is proposed to derive optimal radio frequency drives applied to the Auxiliary path of the DPA to restore power performances while avoiding large signal voltage clipping of active cells. The proposed analytical study is corroborated with harmonic balance simulated results of a C-band, 20-W GaN DPA prototype. The fabricated dual-input DPA prototype has been measured under 1.5-VSWR mismatch configurations to validate the proposed analysis.
Herbicide-resistant weeds in turfgrass: current status and emerging threats
Authors: Brosnan James T. , Elmore Matthew T. , Bagavathiannan Muthukumar V. 
Published: June 2020

AbstractHerbicide-resistant weeds pose a severe threat to sustainable vegetation management in various production systems worldwide. The majority of the herbicide resistance cases reported thus far originate from agronomic production systems where herbicide use is intensive, especially in industrialized countries. Another notable sector with heavy reliance on herbicides for weed control is managed turfgrass systems, particularly golf courses and athletic fields. Intensive use of herbicides, coupled with a lack of tillage and other mechanical tools that are options in agronomic systems, increases the risk of herbicide-resistant weeds evolving in managed turfgrass systems. Among the notable weed species at high risk for evolving resistance under managed turf systems in the United States are annual bluegrass, goosegrass, and crabgrasses. The evolution and spread of multiple herbicide resistance, an emerging threat facing the turfgrass industry, should be addressed with the use of diversified management tools. Target-site resistance has been reported commonly as a mechanism of resistance for many herbicide groups, though non–target site resistance is an emerging concern. Despite the anecdotal evidence of the mounting weed resistance issues in managed turf systems, the lack of systematic and periodic surveys at regional and national scales means that confirmed reports are very limited and sparse. Furthermore, currently available information is widely scattered in the literature. This review provides a concise summary of the current status of herbicide-resistant weeds in managed turfgrass systems in the United States and highlights key emerging threats.
Common ragweed (Ambrosia artemisiifolia) seed shattering in wheat, corn, and soybean
Authors: Simard Marie-Josée , Nurse Robert E. , Page Eric R. , Bourgeois Gaétan 
Published: June 2020

AbstractBefore any late-season weed control operations are planned to manage herbicide-resistant weeds, it is essential to evaluate the plants’ maturity and shattering potential. Our goal was to assess the seed-shattering phenology of common ragweed (Ambrosia artemisiifolia L.) using pollination bags as seed traps. A secondary goal was to evaluate the efficiency of these traps. Trials were conducted from 2014 to 2017 at two locations in eastern Canada (Saint-Jean-sur-Richelieu, QC, and Harrow, ON). At each location, three adjacent fields were seeded with spring wheat (Triticum aestivum L.), soybean [Glycine max (L.) Merr.], or corn (Zea mays L.). Each field was divided into four replicate blocks that included two treatment plots with 5 weeds m−2 planted on the same date as the crop or when crop plants had two leaves (early or late emergence). To evaluate shattering in time, the experiment included up to 12 weekly collection dates (subplots). In each subplot, weeds were individually bagged at flowering (using mesh bags) until collection, when the number and viability of shattered and retained seeds per plant was recorded. Weather data as well as crop and weed stages were recorded. The effect of the pollen bags on seed retrieval and viability was evaluated by installing open and closed bags in corn and uncropped (bare) plots at a single location. Ambrosia artemisiifolia seed biomass was equivalent or higher in closed bags, and seed viability was equivalent or slightly reduced. No seeds were produced before harvest in spring wheat, as dispersal started in September. The percentage of seeds retained on the plant decreased linearly (1 site-year) or followed a logistic equation (4 site-years) with day of year or growing degree days. Dispersal in time was similar between early- and late-emerging weeds and similar in both corn and soybean. On average, more than 50% of A. artemisiifolia seeds were dispersed before harvest in corn and soybean.
Estimation of Temporal Variability of Differential Instrumental Biases of NavIC Satellites and Receiver Using Kalman Filter
Authors: Bhardwaj Sharat Chandra , Vidyarthi Anurag , Jassal B. S. , Shukla A. K. 
Published: June 2020

AbstractFor various precise navigational applications using Indian NavIC system, it is imperative to have an accurate estimation of the ionospheric line‐of‐sight total electron content (TEC). In dual frequency TEC estimation from code and carrier phase measurements, the error is mainly caused by the satellite and receiver differential instrumental biases, which can be several TEC units. The reason for the existence of these biases is that the signals experience different delays within the satellite and receiver hardware at the two frequencies S1 and L5 of NavIC system. These biases are not stable over the time, maybe due to aging or change in the environment of the satellites and receiver. In this paper, the dynamics of the estimated biases of different satellites of NavIC system and receiver are presented, based on the data collected over 19 months time at Dehradun (Lat.31.26°N, Long.77.99°E), India. Five state Kalman filter algorithm was used for the estimation of differential biases. The initial receiver bias required to run Kalman filter algorithm was determined by applying fitted receiver bias (FRB) technique. The initial satellite biases needed for the purpose were supplied by Space Applications Centre (SAC), Indian Space Research Organization (ISRO), Ahmedabad, India.
Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps
Authors: Kim Ji Heui , Kim Sung Hee , Lim Ji Youn , Kim Doyeon , Jeong In Seong , Lee Dong Kyu , Jang Yong Ju 
Published: June 2020

AbstractDysbiosis of the sinus microbiome affects the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNPs). We investigated whether the sinus microbiota in CRSwNPs is associated with eosinophilic inflammation, especially in relation to innate lymphoid cells (ILCs), prognosis, and serum extracellular vesicles (EVs). Middle meatal swabs and serum from 31 CRSwNPs patients and six healthy controls were analyzed by 16S ribosomal RNA sequencing. ILC2s and cytokines from sinonasal tissues were measured by flow cytometry and ELISA, respectively. The relative abundances (RAs) of bacteria were compared based on eosinophilic inflammation and surgical outcome. The correlations between sinus bacteria and ILC2s, cytokines, and serum EVs were analyzed. The compositions of sinus bacteria were different between groups at the genus level. In eosinophilic CRSwNPs patients, the RA ofAnaerococcuswas significantly decreased (P = 0.010), whereas that ofLachnoclostridiumwas significantly increased (P = 0.038) compared with that in controls. The RA ofLachnoclostridiumshowed a significant positive correlation with interleukin (IL)-5-producing ILC2 populations (R = 0.340,P = 0.049), whereas the RA ofAnaerococcusshowed a negative correlation with IL-5-producing ILC2 populations (R = −0.332,P = 0.055). The RAs ofCorynebacterium,Anaerococcus, andTepidimonaswere significantly decreased in patients with suboptimal outcomes compared with those in patients with optimal outcomes and control subjects. Some sinus bacteria and serum EVs showed positive correlations. CRSwNPs patients showed distinct microbiota compositions based on eosinophilic inflammation in relation to ILC2s and surgical outcome. These findings support a relationship between the microbiota and the host immune response in CRSwNPs.
A phase 1b study of dual PD-1 and CTLA-4 or KIR blockade in patients with relapsed/refractory lymphoid malignancies
Authors: Armand Philippe , Lesokhin Alexander , Borrello Ivan , Timmerman John , Gutierrez Martin , Zhu Lili , Popa McKiver Mihaela , Ansell Stephen M. 
Published: June 2020

AbstractSimultaneously targeting other pathways could increase the activity of PD-1 blockade in lymphoid malignancies not sensitive to single-agent blockade. We explored the safety and efficacy of combined PD-1 and CTLA-4 or KIR blockade in patients with relapsed/refractory (R/R) lymphoid malignancies. This phase 1b trial enrolled adult patients with R/R classical Hodgkin lymphoma (cHL), non-Hodgkin lymphoma (NHL), or multiple myeloma (MM). Patients received nivolumab plus ipilimumab (nivo/ipi) or lirilumab (nivo/liri) until complete response (CR), progression, or unacceptable toxicity. The primary endpoint was safety and tolerability, while secondary endpoints included overall (ORR) and CR rates (CRR), progression-free and overall survival. Sixty-five patients were treated with nivo/ipi, and 72 with nivo/liri. Twenty-nine percent of patients experienced grade 3–4 treatment-related adverse events with nivo/ipi, and 15% with nivo/liri. In cHL, ORR was 74% for nivo/ipi and 76% for nivo/liri, CRRs were 23% and 24%, respectively. In B-NHL and T-NHL, ORR range was 9–22% and CRR was 0–6%. No patient with MM had an objective response. While both combinations were active in cHL, the toxicity of nivo/ipi was higher than expected from nivolumab alone. These data suggest no meaningful improvement in the efficacy of the combinations over single-agent nivolumab in the diseases studied.
Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila
Authors: Zhang Shuo , Zhao Juan , Lv Xiangdong , Fan Jialin , Lu Yi , Zeng Tao , Wu Hailong , Chen Luonan , Zhao Yun 
Published: June 2020

AbstractGenetic robustness is an important characteristic to tolerate genetic or nongenetic perturbations and ensure phenotypic stability. Morphogens, a type of evolutionarily conserved diffusible molecules, govern tissue patterns in a direction-dependent or concentration-dependent manner by differentially regulating downstream gene expression. However, whether the morphogen-directed gene regulatory network possesses genetic robustness remains elusive. In the present study, we collected 4217 morphogen-responsive genes along A-P axis of Drosophila wing discs from the RNA-seq data, and clustered them into 12 modules. By applying mathematical model to the measured data, we constructed a gene modular network (GMN) to decipher the module regulatory interactions and robustness in morphogen-directed development. The computational analyses on asymptotical dynamics of this GMN demonstrated that this morphogen-directed GMN is robust to tolerate a majority of genetic perturbations, which has been further validated by biological experiments. Furthermore, besides the genetic alterations, we further demonstrated that this morphogen-directed GMN can well tolerate nongenetic perturbations (Hh production changes) via computational analyses and experimental validation. Therefore, these findings clearly indicate that the morphogen-directed GMN is robust in response to perturbations and is important for Drosophila to ensure the proper tissue patterning in wing disc.
MetaRibo-Seq measures translation in microbiomes
Authors: Fremin Brayon J. , Sberro Hila , Bhatt Ami S. 
Published: June 2020

AbstractNo method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in a mock microbial community and applied to five different human fecal samples. Unlike RNA-Seq, Ribo-Seq signal of a predicted gene suggests it encodes a translated protein. We demonstrate two applications of this technique: First, MetaRibo-Seq identifies small genes, whose identification until now has been challenging. For example, MetaRibo-Seq identifies 2,091 translated, previously unannotated small protein families from five fecal samples, more than doubling the number of small proteins predicted to exist in this niche. Second, the combined application of RNA-Seq and MetaRibo-Seq identifies differences in the translation of transcripts. In summary, MetaRibo-Seq enables comprehensive translational profiling in microbiomes and identifies previously unannotated small proteins.