bluuebunny/crossref_metadata_2025_split huggingface dataset:
PESEM Proyecto Educativo Socio Empresarial una apuesta para formar, cautivar y educar al público de interés de la Cooperativa del Departamento del Cauca CODELCAUCA
Authors: Realpe-Leyton Mireya , Barreda-Ramírez Concepción 
Published: August 2020

La investigación efectuada responde a la necesidad de establecer una propuesta de Proyecto Educativo Social y Empresarial (PESEM) para la Cooperativa CODELCAUCA, entidad del sector solidario que ofrece sus servicios hace 42 años y es la Cooperativa local más grande del Departamento del Cauca, la investigación tiene como objetivo construir una propuesta de formación que fomente la cultura de la economía solidaria y mejore el sentido de pertenencia del asociado, diseñando estrategias pedagógicas pertinentes que promuevan su participación, planteando una serie de alternativas de capacitación orientadas a mejorar aspectos educativos. La metodología utilizada se enmarca dentro de un enfoque cuantitativo de tipo descriptivo, se hizo uso de herramientas de investigación como la entrevista, la interacción conversacional y la encuesta a 350 asociados; se tuvo conocimiento de la situación actual de la organización y con base en ella se realizó el PESEM para la entidad, su desarrollo permitió identificar las necesidades de formación presentes entre los asociados y demás integrantes de la Cooperativa, como resultado de los cambios socio económico que se han gestado en los últimos años, así mismo, se evidenció el importante papel que cumplen las tecnologías de información y comunicación en los procesos educativos hoy.
Estimation of Leakage Mass Flow Rate through Labyrinth Seal Using CFD Techniques
Authors: Neeharika M , Kumar Hensh Prabhat 
Published: August 2020

Seal design is an essential part for turbo machinery. Seal consisting of fins is placed in a gap between stationary and rotating component to minimize the leakage flow. Seal leakage flow has been considered as an inevitable loss factor that highly affects the efficiency of any machine. During operation of the equipment, thermal expansion/contraction of components take place, which causes variation of the gap between stationary and rotating component. Importance of the study is to understand the flow behavior due to variation of the gap. The variation of gap leads to change of radial clearance between fin to metal component and subsequent change of flow pattern.
The main focus of the paper is to estimate the leakage flow through a labyrinth seal placed between rotor and casing of a typical steam turbine. Numerical techniques using 3D CFD tool are used for this purpose. Three different seal configurations are proposed in the study. The variables of the three seal configurations are radial clearance, number of fins in the flow passage and pressure drop across the seal passages.
As an alternative methodology, an empirical correlation is formulated based on numerical simulation results for one set of radial clearance to estimate mass flow rate through the seal. In order to validate the formulated correlation, mass flow rate is determined for another set of radial clearance and compared with numerical simulation results. It is observed that flow rate estimated from 3D CFD study is around 20% lower compared to empirical correlation.
Diagnosis of Competitive Strategies of SMEs - Quevedo
Authors: Martha Matilde Sandoval Cuji , Julia del RocÃ­o Fajardo Arriaga , MÃ³nica MarÃ­a Sandoval Cuji , Luis Amable Zambrano Medranda 
Published: August 2020

The competitive strategies developed by Quevedo's microenterprises are very important, in order to know how they are going to compete in the markets, it was possible to identify them by means of a diagnosis based on the study methodology SWOT Analysis Matrix, through which it was possible To know the strengths, opportunities, weaknesses and threats that have affected the competitiveness and factors of success achieved by small and medium enterprises in the canton of Quevedo.
The objective population consisted of 2045 small and medium entrepreneurs of the Quevedo canton, obtained from the Chamber of Commerce of Quevedo (CCQ, 2015), of which 361 SMEs were surveyed.
The results of the survey show that firms, in relation to the competitive situation of the market, compete on the basis of lower prices, based on even lower costs, product quality; The variety of products that have SMEs to meet the requirements of customers, on the other hand the owners of SMEs - Quevedo define the competitive positions they have to achieve a better position in the market and a competitive advantage, Competition to existing competitors; The competition threatens the entry of new competitors and bargaining power of suppliers
On the other hand, the most recognized and applied strategies among the SMEs of the study are: the strategies of organizational growth, it has not defined its organizational charts nor have a manual of functions and processes; They also use financial growth strategies as the acquisition of resources, through bank and non-bank financing and the adequate costs of their goods or services, entrepreneurs have great weakness in strategies and work climate, where they do not apply a technical system of Recruitment for the selection of personnel, nor do they train in order to allow the entity to be more competitive; Also consider that the best marketing strategy is the knowledge of the business through Advertising, companies assume the position of market leaders by expanding the size of the total market and expand their market share through cost reductions, Consequently, in order for a strategy to be successful, companies must be related to the objectives, values and goals, with the resources and capabilities of the organization, its environment, structure and organizational systems.
Enseñanza de Anatomía e Histología en tiempos de pandemia: adaptaciones para una cursada a distancia
Authors: Ibáñez Shimabukuro Marina , Sbaraglini María Laura , Gangoiti María Virginia , Enrique Nicolás , D´ambrosio Marianela , Speroni Francisco 
Published: August 2020

La pandemia por el coronavirus impuso una situación sanitaria extraordinaria cuyas medidas de contención y prevención gubernamentales implicaron el aislamiento social y consecuentemente por disposición de la UNLP, la interrupción de clases presenciales a partir del 16 de marzo del 2020.
En función de las nuevas circunstancias, docentes y estudiantes atravesamos desafíos que exaltan el carácter complejo y dinámico de la trama educativa y que revelan de manera patente esa amalgama de lo académico, lo político, lo institucional, lo cultural y lo histórico como invita a pensar el eje temático elegido para este relato de experiencia pedagógica.
Contemplar el impacto del aislamiento social en las realidades de lxs estudiantes y docentes nos impulsó a repensar objetivos y horizontes. Y volver sobre nuestras prácticas nos llevó a proponer una reorganización curricular, rediseñar materiales didácticos (cuestionarios, videos de clases) y adaptar los dispositivos de evaluación.
Compartimos aquí los desafíos pedagógicos sobre los cuales reflexionamos, en tanto profesionales de la educación, y las experiencias de transformación que estamos desarrollando en la comisión para Farmacia, Licenciatura en Óptica Ocular y Optometría, Profesorado en Física, Profesorado en Química y Licenciatura en Biotecnología y Biología Molecular de la Cátedra de Anatomía e Histología (AeH com. FOBP) de la Facultad de Ciencias Exactas, UNLP.
PALABRAS CLAVE: Anatomía e Histología – Pandemia - Cursada a Distancia
Age- and breed-matched retrospective cohort study of malignancies and benign skin masses in 660 dogs with allergic dermatitis treated long-term with versus without oclacitinib
Authors: Lancellotti Brittany A. , Angus John C. , Edginton Heather D. , Rosenkrantz Wayne S. 
Published: August 2020

Abstract

OBJECTIVE
To compare the cumulative incidences of malignancies and benign skin masses and the mean age at death or euthanasia in dogs with allergic dermatitis treated long-term with versus without oclacitinib.

ANIMALS
660 client-owned dogs.

PROCEDURES
Medical records were searched to identify dogs with allergic dermatitis treated for ≥ 6 months with oclacitinib (exposed dogs; n = 339) versus other available treatments before the introduction of oclacitinib (nonexposed dogs; 321) and with ≥ 24 months of follow-up information available. Nonexposed dogs were age and breed matched with 321 of the exposed dogs; data for the remained 18 exposed dogs were included in statistical analyses. Results for cumulative incidences of malignancies and other variables were compared between groups, and the effect of daily maintenance dosage of oclacitinib on cumulative incidences of malignancies and other skin masses was evaluated within the exposed group.

RESULTS
No meaningful differences were detected in the cumulative incidences of malignancies and overall skin masses or the mean age at death or euthanasia for dogs in the exposed group (16.5% [56/339], 56.6% [192/339], and 11.2 years [n = 80], respectively) versus the nonexposed group (12.8% [41/321], 58.3% [187/321], and 11.8 years [71], respectively). There was no association identified between daily maintenance dosage of oclacitinib and odds of malignancy or benign skin masses for dogs in the exposed group.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that long-term treatment with oclacitinib did not pose additional risk for malignancy in dogs; however, veterinarians should continue to observe FDA-approved label warning and precaution statements for oclacitinib and regularly screen for neoplasia in dogs with allergic skin disease treated with or without oclacitinib.
Novel Immunotherapeutic Approach in Gastric Cancer
Authors: Gulubova M. , Hadzhi M. , Ignatova M. , Chonov D. , Balakan O. , Aydan M. , Ananiev J. 
Published: August 2020

Abstract
Gastric cancer (GC) is suitable for immunotherapy because 80% of it display microsatellite and chromosomal instability, some mutations and DNA hypermethylation. Therefore, GC is more immunogenic. The immunotherapy with monoclonal antibodies, adoptive cell therapy and checkpoint inhibition are discussed. The commonly used monoclonal antibodies are Trastuzumab targeting HER2 and Bevacizumab suppressing VEGF and tumor angiogenesis. Treatment with tumor-specific T cells is called adoptive cell therapy. There is experience with the application of tumor infiltrating lymphocytes (TILs), cytotoxic T lymphocytes (CTLs) and cytokine-induced killer cells (CIK). This review discusses the therapy with innate immune cells with anti-tumor activity such as dendritic cells and NK cells. The checkpoint inhibition was also reviewed. In conclusion, it could be stated that the immunotherapy of GC has the potential to provide a more favorable outcome to patients with GC, but it also have some limitations which need to be considered.
Nonlinear Relationship based on Range Quadratic Loss Function
Authors: Sun Zhangjie 
Published: August 2020

Abstract
This paper uses the interval quadratic preference loss function to establish the threshold model of exchange rate volatility by Taylor series expansion, and GMM method to study the intervention behavior of exchange rate. It found that the central bank has asymmetric intervention preference for exchange rate, discontinuous and nonlinear intervention for exchange rate, and there is an intervention threshold, and the central bank has a certain degree of “fear of appreciation” trend. To some extent, asymmetric interval intervention preference has resulted in the rapid growth of China's foreign exchange reserves.
Users’ Sentiment Analysis of Shopping Websites Based on Online Reviews
Authors: Wang Xiaohong , Dong Shuang 
Published: August 2020

Abstract
With the rapid development of online shopping, how to explore the value of online reviews, so as to give full play to their role in potential users’ purchasing decisions. Based on text mining and quantitative analysis, this paper studies the sentiment analysis of online reviews on B2C shopping website. The main attributes of commodity or service are extracted based on the order of word frequency in the online reviews. Text analysis method is used to judge the relationship between attributes of commodity or service and its emotional words. The fine-grained sentimental polarity and intensity of attributes are identified to analyze users’ concerns and preferences. The research shows that users pay more attention to the configuration and after-sales service of mobile, and have a positive sentimental orientation to most of attributes, especially unlocking function, hand feeling attribute and logistics service; and have a neutral sentimental orientation towards the attributes of battery and memory, and a negative sentimental orientation towards the membrane of mobile phone. The results can provide a reference for consumers to make purchasing decisions, for enterprises to improve product quality, and for shopping platform to optimize service.
Research on the Pricing Model about Online Celebrity Economy
Authors: Li Yuqi 
Published: August 2020

Abstract
With the continuous development of China's Internet economy, the model of grasping Internet economy benefit is diversified. Since 2016, the online celebrity economy has formed a trend of Internet marketing, and the online celebrity economic industry chain further has established along with the further development of MCN institutions. The relationship among the overall industry upstream and downstream sectors become closer and closer and even appear the trend of vertical cooperation. This paper is aimed at expressing the pricing mechanism of the online celebrity industrial chain and applies game theory and mathematical analysis to propose a reasonable pricing model
A Non-Synonymous Single Nucleotide Polymorphism in FASN Gene Alters FASN Enzyme Activity in Subcutaneous and Intramuscular Adipose Tissue in Holstein Friesian Steers
Authors: Cancino-Baier David , Muñoz Erwin , Quiñones John , Beltrán Jorge F. , Fuentes Fernanda , Farías Jorge , Lorenzo José Manuel , Diaz Rommy , Inostroza Karla , Ferraz José Bento Sterman , Sepúlveda Néstor 
Published: August 2020

Abstract
The FASN enzyme plays a key role in fatty acids synthesis as the main long-chain fatty acid synthesizer. A non-synonymous SNP (single nucleotide polymorphism) (g.17925A>G) located in the thioesterase domain of this enzyme and an effect in fat deposition has been observed, but has not been evaluated in this breed and, moreover, the reason whereby this occurs remains unclear. The objective of this study was to evaluate the effect of this SNP on the activity of FASN enzyme in subcutaneous and intramuscular adipose tissue from Holstein Friesian steers. To achieve this, 196 animals were sampled in a local abattoir, genotyped for the FASN g.17924A>G SNP and characterized for fatty acid profile. Then a sub-sample of 20 animals per genotype were selected to extract the total protein from subcutaneous and intramuscular adipose tissue to estimate the FASN enzyme activity. The FASN activity for each genotyped animal was assessed indirectly by measuring the decrease in the absorbance of NADPH at 340 nm by spectrophotometry in a 24 well plate in the presence of Acetyl-CoA, Malonyl-CoA, and NADPH. To assess the impact of SNP induced amino acid changes in FASN protein structure, in-silico simulations were performed. Our results indicated that FASN g.17924A>G SNP induces a change in the enzyme activity in subcutaneous adipose tissue, which is higher when the AA genotype is present and lower in the presence of the AG genotype. The in-silico analysis of the amino acid substitution shows that there was a structural change in the dimeric form of the protein between genotypes. Moreover, the global energy between subunits is lower and more favorable when the AA genotype is present and higher and less favorable for the AG genotype. It was also found that the fatty acid profile of subcutaneous adipose tissue was affected when the AG genotype was present, decreasing the C16:0 fatty acid levels and increasing the C18:0 fatty acid levels. The FASN g.17924A>G SNP alters the FASN enzyme structure and activity, leading to a variation in the fatty acid composition of subcutaneous adipose tissue in Holstein Friesian steers. Implications: This SNP could be considered as a tool to improve the fat deposition or marbling and the fatty acid profile in cattle.
Chemical composition, antimicrobial activity and chromosome number of Hertia cheirifolia L. from Algeria
Authors: Abdelkader Ounoughi , Messaoud Ramdani , Takia Lograda , Pierre Chalard , Gilles Figueredo 
Published: August 2020

Abstract
The aims of this work are to investigate the chemical composition, the antibacterial activity of the essential oil and the chromosome numbers of two populations of Hertia cheirifolia. The samples were collected in the flowering stage, in eastern Algeria locality. The aerial parts of H. cheirifolia were submitted to a hydro-distillation. GC and GC / MS analysed the chemical compositions of the obtained essential oils. The antibacterial activity of essential oils was evaluated using the disks diffusion method against ten bacterial strains. For karyotypic analysis, the squashing method is used. Fifty-eight compounds representing 98.93% of the total oil were identified in H. cheirifolia. The chemical composition is dominated by the presence of major products, α-pinene (48.49 - 53.85%) and Germacrene-D (2.64 - 12.66%). Two distinct chemical breeds were identified, the α-pinene-spathulenol of Batna population, and the α-pinene-germacrene-D of Setif population. The essential oil of H. cheirifolia has a moderate activity against bacteria tested. In contrast, the strains E. coli ATCC 25922, P. syringae ATCC 53543 and E. fecalis ATCC 49452 are resistant to H. cheirifolia essential oils. The observations of root cells meristematic at metaphase of H. cheirifolia gave a diploid chromosome number 2n = 2x = 20, with a basic chromosome number (x= 10).
Antimicrobial Activity of Phenolic Extract of Apple Pomace against Paenibacillus larvae and its Toxicity on Apis mellifera
Authors: Giménez-Martínez Pablo , Ramírez-Ambrosi Maria , Alonso-Salces Rosa Maria , Gallo Blanca , Berrueta Luis Angel , Maggi Matias , Fuselli Sandra 
Published: August 2020

Abstract

Apis mellifera populations are exposed to different biotic and abiotic stressors that affect bee survival. Paenibacillus larvae, the causative agent of American foulbrood, is one of the most important bacterial pathogens that affect bee health. In some countries, the use of antibiotics is the most common method for the prevention and treatment of P. larvae infected colonies, however this application can also increase the risk of occurrence of resistant strains. An ecological alternative is the use of vegetal extracts containing bioactive compounds, such as polyphenols. The aim of this study is to check the antimicrobial activity of phenolic extracts of apple pomace, from the cider industry, against P. larvae strains by the broth micro dilution method. In addition, the toxicity of the phenolic extracts on A. mellifera was verified using the complete exposure method. All extracts contain from 715.31 to 11348.16 μg gal/g DW, determined by Folin-Ciocalteu show antimicrobial activity against P. larvae genotype ERIC I, ranging from 23 μg/mL to 150 μg/mL. Toxicity assays of apple pomace extracts on adult bees exhibited a maximum mortality of 18% after 48h. This promising alternative will be used in the future to evaluate its toxicity at a field level.
Effect of Residual Stresses on the Stress Intensity Factor of Cracks in a Metal Matrix Composite: Numerical Analysis
Authors: Ramdoum S. , Bouafia F. , Serier B. , Fekirini H. 
Published: August 2020

Abstract
In this work, the finite element method was used to determine the stress intensity factors as a function of crack propagation in metal matrix composite structure, A three-dimensional numerical model was developed to analyze the effect of the residual stresses induced in the fiber and in the matrix during cooling from the elaboration temperature at room temperature on the behavior out of the composite. Added to commissioning constraints, these internal stresses can lead to interfacial decohesion (debonding) or damage the matrix. This study falls within this context and allows cracks behavioral analysis initiated in a metal matrix composite reinforced by unidirectional fibers in ceramic. To do this, a three-dimensional numerical model was analyzed by method of finite element (FEM). This analysis is made according to several parameters such as the size of the cracking defects, its propagation, its interaction with the interface, the volume fraction of the fibers (the fiber-fiber interdistance), orientation of the crack and the temperature.
Vibration Analysis and Control of Locomotive System
Authors: Shireesha Y. , Venkata Suresh B. , Sateesh B. 
Published: August 2020

Abstract
Vibration is an undesirable phenomenon of ground vehicles like locomotives and vibration control of vehicle suspension system is an active subject of research. The main aim of the present work is to modeling and analysis of locomotive system. The simplified equations for dynamical locomotive are firstly established. Then the dynamical nature of the locomotive without control is investigated, and also active control suspension and passive control suspension are compare and discussed. The obtained simulation shows that suspension of the locomotive with feedback control could decrease the locomotive vibration. According to the above control strategy along with angular acceleration it also reduces the possibility of vibration of the locomotive body, to improves the stability of vehicle operation.
Geostatistical Methods as a Tool Supporting Revitalization of Industrially Degraded and Post-Mining Areas
Authors: Zawadzki Jarosław , Fabijańczyk Piotr , Przeździecki Karol 
Published: August 2020

Abstract
Post-industrial and post-mining areas have often been under strong anthropogenic pressure for a long time. As a result, such areas, after the ending of industrial activity require taking steps to revitalize them. It may cover many elements of the natural or urban environment, such as water, soil, vegetated areas, urban development etc. To carry out revitalization, it is necessary to determine the initial state of such areas, often using selected chemical, geophysical or ecological. After that it is also important to properly monitor the state of such areas to assess the progress of the revitalization process. For this purpose a variety of change detection technics were developed. Post-industrial areas are very often characterized by a large extent, are difficult to access, have complicated land cover. For this reason, it is particularly important to choose appropriate methods to assess the degree of pollution of such areas. Such methods should be as economical as possible and time-effective. A very desirable feature of such methods is that they should allow a quick assessment of the entire area. Geostatistics supplemented by modern remote sensing can be effective for this purpose. Nowadays, using remote sensing, it is possible to gather information simultaneously from the entire, even vast area, with high spatial, spectral and temporal resolution. Geostatistics in turn provides many tools that are able to enable rapid analysis and inference based on even very complicated often scarce spatial data sets obtained from ground measurement and satellite observations. The goal of the article was to present selected results obtained using geostatistical methods also related to remote sensing, which may be helpful for decision makers in revitalizing post-industrial and post-mining areas. The results described in this paper were based mostly on the previous studies, carried out by authors.