bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of new mercury–manganese stars, including a fast rotator
Authors: González J F , Nuñez N E , Saffe C , Alejo A D , Veramendi M E , Collado A 
Published: November 2020

ABSTRACT
The origin of mercury–manganese (HgMn) stars is still poorly understood and the statistical analysis of an extensive sample of well characterized objects would be very valuable. Nevertheless, the compilation of a clean and reliable list of all known HgMn stars, and complete characterization of those objects, is still a pending issue. We report the identification of 13 new HgMn stars from our own spectroscopic observations and from publicly available spectral libraries. In addition, we perform a thorough literature search to give a list of 46 confirmed HgMn stars (plus a further nine suspected HgMn stars) discovered over the last years or neglected by other compilations. When required, we performed specific observations to confirm doubtful cases. For the 13 newly identified HgMn stars we derived photospheric chemical abundances by spectral synthesis. Besides Hg and Mn, which are overabundant in the whole sample, P, Ga, and Xe are overabundant in the hottest stars of the sample, and Sr, Zr, and Pt among the coolest; Y is present in most stars of the sample. Three of these new HgMn stars are members of open clusters: HD 93549 in IC 2602, HD 96473 in NGC 3532, and HD 322659 in NGC 6281. Furthermore, our sample includes HD 145842, an object remarkable for its high rotation. In fact, its projected rotational velocity of ve sin i = 124 km s−1 is the highest measured in any HgMn star and is more than 30 per cent above the theoretical limit predicted by the diffusion theory, which makes HD 145842 a challenging test case for the current models.
Extremely band-limited repetition from a fast radio burst source
Authors: Kumar P , Shannon R M , Flynn C , Osłowski S , Bhandari S , Day C K , Deller A T , Farah W , Kaczmarek J F , Kerr M , Phillips C , Price D C , Qiu H , Thyagarajan N 
Published: November 2020

ABSTRACT
The fast radio burst (FRB) population is observationally divided into sources that have been observed to repeat and those that have not. There is tentative evidence that the bursts from repeating sources have different properties than the non-repeating ones. In order to determine the occurrence rate of repeating sources and characterize the nature of repeat emission, we have been conducting sensitive searches for repetitions from bursts detected with the Australian Square Kilometre Array Pathfinder (ASKAP) with the 64-m Parkes radio telescope, using the recently commissioned Ultra-wideband Low (UWL) receiver system, over a band spanning 0.7–4.0 GHz. We report the detection of a repeat burst from the source of FRB 20190711A. The detected burst is 1 ms wide and has a bandwidth of just 65 MHz. We find no evidence of any emission in the remaining part of the 3.3 GHz UWL band. While the emission bandwidths of the ASKAP and UWL bursts show ν−4 scaling consistent with a propagation effect, the spectral occupancy is inconsistent with diffractive scintillation. This detection rules out models predicting broad-band emission from the FRB 20190711A source and puts stringent constraints on the emission mechanism. The low spectral occupancy highlights the importance of sub-banded search methods in detecting FRBs.
A population of galaxy-scale jets discovered using LOFAR
Authors: Webster B , Croston J H , Mingo B , Baldi R D , Barkus B , Gürkan G , Hardcastle M J , Morganti R , Röttgering H J A , Sabater J , Shimwell T W , Tasse C , White G J 
Published: November 2020

ABSTRACT
The effects of feedback from high luminosity radio-loud active galactic nuclei (AGN) have been extensively discussed in the literature, but feedback from low-luminosity radio-loud AGN is less well understood. The advent of high sensitivity, high angular resolution, large field-of-view telescopes such as LOFAR is now allowing wide-area studies of such faint sources for the first time. Using the first data release of the LOFAR Two Metre Sky Survey (LoTSS) we report on our discovery of a population of 195 radio galaxies with 150-MHz luminosities between 3 × 1022 and 1.5 × 1025 WHz−1 and total radio emission no larger than 80 kpc. These objects, which we term galaxy-scale jets (GSJ), are small enough to be directly influencing the evolution of the host on galaxy scales. We report upon the typical host properties of our sample, finding that 9 per cent are hosted by spirals with the remainder being hosted by elliptical galaxies. Two of the spiral-hosted GSJ are highly unusual with low radio luminosities and FRII-like morphology. The host properties of our GSJ show that they are ordinary AGN observed at a stage in their life shortly after the radio emission has expanded beyond the central regions of the host. Based on our estimates, we find that about half of our GSJ have internal radio lobe energy within an order of magnitude of the ISM energy so that, even ignoring any possible shocks, GSJ are energetically capable of affecting the evolution of the host. The current sample of GSJ will grow in size with future releases of LoTSS and can also form the basis for further studies of feedback from low-luminosity radio sources.
Revisiting the dust destruction efficiency of supernovae
Authors: Priestley F D , Chawner H , Matsuura M , De Looze I , Barlow M J , Gomez H L 
Published: November 2020

ABSTRACT
Dust destruction by supernovae is one of the main processes removing dust from the interstellar medium (ISM). Estimates of the efficiency of this process, both theoretical and observational, typically assume a shock propagating into a homogeneous medium, whereas the ISM possesses significant substructure in reality. We self-consistently model the dust and gas properties of the shocked ISM in three supernova remnants (SNRs), using X-ray and infrared (IR) data combined with corresponding emission models. Collisional heating by gas with properties derived from X-ray observations produces dust temperatures too high to fit the far-IR fluxes from each SNR. An additional colder dust component is required, which has a minimum mass several orders of magnitude larger than that of the warm dust heated by the X-ray emitting gas. Dust-to-gas mass ratios indicate that the majority of the dust in the X-ray emitting material has been destroyed, while the fraction of surviving dust in the cold component is plausibly close to unity. As the cold component makes up virtually all the total dust mass, destruction time-scales based on homogeneous models, which cannot account for multiple phases of shocked gas and dust, may be significantly overestimating actual dust destruction efficiencies, and subsequently underestimating grain lifetimes.
PK-DB: pharmacokinetics database for individualized and stratified computational modeling
Authors: Grzegorzewski Jan , Brandhorst Janosch , Green Kathleen , Eleftheriadou Dimitra , Duport Yannick , Barthorscht Florian , Köller Adrian , Ke Danny Yu Jia , De Angelis Sara , König Matthias 
Published: November 2020

AbstractA multitude of pharmacokinetics studies have been published. However, due to the lack of an open database, pharmacokinetics data, as well as the corresponding meta-information, have been difficult to access. We present PK-DB (https://pk-db.com), an open database for pharmacokinetics information from clinical trials. PK-DB provides curated information on (i) characteristics of studied patient cohorts and subjects (e.g. age, bodyweight, smoking status, genetic variants); (ii) applied interventions (e.g. dosing, substance, route of application); (iii) pharmacokinetic parameters (e.g. clearance, half-life, area under the curve) and (iv) measured pharmacokinetic time-courses. Key features are the representation of experimental errors, the normalization of measurement units, annotation of information to biological ontologies, calculation of pharmacokinetic parameters from concentration-time profiles, a workflow for collaborative data curation, strong validation rules on the data, computational access via a REST API as well as human access via a web interface. PK-DB enables meta-analysis based on data from multiple studies and data integration with computational models. A special focus lies on meta-data relevant for individualized and stratified computational modeling with methods like physiologically based pharmacokinetic (PBPK), pharmacokinetic/pharmacodynamic (PK/PD), or population pharmacokinetic (pop PK) modeling.
POTENTIAL ENVIRONMENTAL HAZARD TO THE PUBLIC FROM THE OPERATION OF URANIUM MINING AND MILLING FACILITY
Authors: Rweyemamu Mujuni , Kim Juyoul 
Published: November 2020

Abstract
Mining and milling processes could cause potential radiological exposures to the public. The objective of this study was to estimate the off-site radiological doses expected to be received by the public as a result of uranium mining and milling activities at Mkuju River Project in the United Republic of Tanzania. MILDOS-AREA was used to estimate off-site doses along with RESRAD-OFFSITE for comparison and verification. Since the mining has not yet started, the conceptual scenario was chosen. Using the concept of the most exposed individual, the location of the nearest residence (receptor) was chosen at 2.5 km from the site with other receptors being the fence boundary and grazing area being at 1.0 and 1.8 km, respectively. Yellowcake stack (point source), ore pad and two tailing piles where each had an area of 2.5 × 105 m2 were chosen to be the source of radiological contamination. The radiological source term was obtained from the concentration of 226Ra and 232Th in soil obtained from the previous studies of environmental impact assessments. Meteorological and site-specific data were used for this analysis. The estimated total effective dose equivalent (TEDE) for the nearest residence which was calculated by MILDOSE-AREA ranged from 2.5 × 10−2 to 4.45 × 10−2 mSv/y during the operation of 13 y. The result of RESRAD-OFFSITE ranged from 7.19 × 10−2 mSv/y for the first year to 7.43 × 10−2 mSv/y in the final year. This implied all the estimated TEDEs were below the dose limit and dose constraint of 1 and 0.3 mSv/y, respectively, as suggested by the International Atomic Energy Agency. Hence, it was found that there was no potential radiological concern of uranium mining at Mkuju River Project. It was found that using MILDOS-AREA it is possible to estimate dose at different distances from the facility. Therefore, this study apart from estimating the off-site doses, it can be used for planning of public and social premises before the commencement of the project. That is the distance from the facility where the public should be located as well as other locations for social activities.
The energy requirements of racehorses in training
Authors: Ebert Mark , Moore-Colyer Meriel J S 
Published: November 2020

AbstractThe aim of this study was to estimate the energy requirements of Thoroughbred racehorses in active training for flat racing. Twenty-two Thoroughbred racehorses in England were measured over periods from 6 to 15 wk, which included periods of active race training and temporarily reduced training. Energy intake was determined by measuring daily feed consumption. Energy output was measured using heart rate monitors during 730 training sessions, relating heart rate (HR) to oxygen consumption (VO2) and converting VO2 to energy. Field maintenance requirements were calculated by deducting the marginal energy cost of training from energy input. The mean field maintenance expenditure during periods of active race training was 0.1731 megajoules (MJ) of metabolizable energy (ME)/kg of bodyweight (BW)/d (SD = 0.0174, CI = 0.0073, n = 22 horses, 193 wk). This result is 11% to 66% greater than the official guidance found in the United States, France, Germany, and the Netherlands. Heart rate monitoring revealed a mean energy expenditure for exercise of 0.0212 MJ ME/d (SD = 0.0049, CI = 0.0007, n = 22 horses) for racehorses in active race training, a result 70% to 82% below the official guidance. The total mean energy expenditure for racehorses in active race training was 0.1943 MJ ME/kg/d (SD = 0.0177, CI = 0.0078, n = 20 horses 193 wk), 4% to 22% less than the official guidance. Horses actively racing had a 12% higher maintenance requirement than those in training but not yet racing (P = 0.01). The 2- and 3-yr-old horses did not gain weight during active race training, but grew slowly during breaks in training. This study explores the factors affecting energy balance in racehorses, and provides updated findings for their maintenance and training requirements.
Asymptomatic bacteriuria and urinary tract infections in kidney transplant recipients
Authors: Coussement Julien , Kaminski Hannah , Scemla Anne , Manuel Oriol 
Published: November 2020

Purpose of review
Urinary tract infection (UTI) is the most common infection in kidney transplant recipients (KTRs). Several elements increase the risk of UTI and/or modify its clinical presentation among KTRs (e.g. immunosuppressive therapy, kidney allograft denervation, and use of urinary catheters). Also, KTRs may have UTIs because of difficult-to-identify and/or difficult-to-treat organisms. We provide an overview of the current knowledge regarding bacterial UTIs in KTRs, with a focus on recent findings.

Recent findings
There is accumulating evidence from clinical trials that screening for and treating asymptomatic bacteriuria is not beneficial in most KTRs (i.e. those who are ≥1–2 months posttransplant and do not have a urinary catheter). These patients have a point-prevalence of asymptomatic bacteriuria of only 3% and treating asymptomatic bacteriuria probably does not improve their outcomes. There is no clinical trial evidence to guide the management of symptomatic UTI in KTRs. Several important clinical questions remain unanswered, especially regarding the management of posttransplant pyelonephritis and the prevention of UTI in KTRs.

Summary
Despite its frequency and associated morbidity, UTI after kidney transplantation is an understudied infection. In an era of increasing antimicrobial resistance and limited resources, further research is needed to ensure optimal use of antimicrobials in KTRs with UTI.
Inflammatory Myofibroblastic Tumor of the Liver Mimicking Metastasis on 18F-FDG PET/CT
Authors: Raad Roy A. , Haddad Laura , Jabbour Teddy , El-Rassi Ziad 
Published: November 2020

Abstract
A 62-year-old woman with history of stage III endometrial cancer was found to have a small enhancing liver lesion on follow-up abdominal CT and MRI, suspicious for metastasis. Subsequent 18F-FDG PET/CT was performed, demonstrating intense uptake within the liver lesion, consistent with metastasis. Subsequently, laparoscopic wedge liver lesion resection was performed. Histopathologic examination confirmed the diagnosis of inflammatory myofibroblastic tumor (IMT) with predominant inflammatory cells. Although solitary liver IMTs are rare occurrences with imaging features overlapping with malignancy, IMT should be considered in the differential diagnosis of suspicious liver lesions, especially when the pattern of spread is unusual.
FDG-Avid Pulmonary Nodules and Tracheobronchial Mural Inflammation in IgG4-Related Disease
Authors: Namireddy Meera K. , Consul Nikita , Sher Andrew C. 
Published: November 2020

Abstract
We report the case of a 9-year-old girl who presented with acute fevers, cough, and epistaxis with nasal swelling, and found to have a nasal mass. On 18F-FDG PET/CT, she was found to have marked nodal and pulmonary parenchymal disease with diffuse and symmetrical mural FDG uptake within the trachea and bronchial tree. The differential diagnosis was broad, and she was diagnosed with IgG4-RD (IgG4-related disease) and improved on appropriate treatment. To our knowledge, there are only 2 other pediatric cases of IgG4-related pulmonary disease in the literature, and our case serves as a unique constellation of intrapulmonary IgG4-RD imaging findings.
Intravenous Recombinant Tissue-Type Plasminogen Activator Thrombolysis for Acute Central Retinal Artery Occlusion
Authors: Wang Xiaotang , Liu Yong , Suo Yan , Qin Dan , Ren Meixia , Lei Runjia , Zhang Yanchun , Wang Ying 
Published: November 2020

Introduction:
Central retinal artery occlusion (CRAO), an ocular stroke, causes severe and permanent visual impairment. Thrombolytic therapy is currently the main treatment option for CRAO. Intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) has been extensively applied in the treatment of CRAO with the proven advantages of effectiveness and safety. This meta-analysis aimed to assess the efficacy of intravenous rt-PA thrombolysis for the management of CRAO by evaluating the pooled evidence.

Methods:
A comprehensive literature search of electronic databases including PubMed, OVID, and Cochrane Library was conducted up to and including March 2019. All studies reporting visual outcomes after CRAO with thrombolytic therapy were collected. Data on visual acuity and adverse events were recorded and assessed in this analysis. Data were inputted into the statistical software of STATA. The studies were weighed by the inverse of the variance and merged in a random-effects model.

Results:
The systematic review process yielded 7 eligible studies including 121 patients with CRAO who received the intravenous rt-PA treatment. Sixty-two patients showed improvement in visual acuity (52.0%; 95% CI, 34.0%–70.0%) following rt-PA intravenous thrombolytic therapy. The observed improvement rate in the intravenous rt-PA treatment group was significantly higher than the conservative treatment group (40.4% vs. 13.0%; OR = 5.16; 95% CI, 1.90–14.05). The incidence rate of complications was relatively low (11 out of the 121 patients). Hemorrhage (9/11) was the major reported complication. Mortality was zero.

Discussion:
This meta-analysis indicated that intravenous rt-PA thrombolysis could be an effective and safe strategy for the management of CRAO. However, a more detailed large-scale clinical trial is warranted to strengthen the evidence-based therapeutic guidance.
Role of Von Willebrand Factor after Injury: It May Do More Than We Think
Authors: Zeineddin Ahmad , Dong Jing-Fei , Wu Feng , Terse Pranaya , Kozar Rosemary A. 
Published: November 2020

ABSTRACT
Acute traumatic coagulopathy is a complex phenomenon following injury and a main contributor to hemorrhage. It remains a leading cause of preventable death in trauma patients. This phenomenon is initiated by systemic injury to the vascular endothelium that is exacerbated by hypoperfusion, acidosis, and hypothermia and leads to systemic activation of the coagulation cascades and resultant coagulopathy. Many previous studies have focused on endotheliopathy with targeted markers such as syndecan-1, soluble thrombomodulin, and plasma adrenaline as potential culprits for initiation and propagation of this state. However, in more recent studies, hyperadhesive von Willebrand factor (VWF), which is released following endothelial injury, and its cleaving metalloprotease ADAMTS13 have emerged as significant targets of the downstream effect of endothelial breakdown and coagulation dysregulation. Elucidation of the mechanism by which the dysregulated VWF-ADAMTS13 axis leads to endothelial dysfunction and coagulopathy after trauma can help identify new targets for therapy and sites for intervention. Much of what is known mechanistically regarding VWF stems from work done in traumatic brain injury. Following localized brain injury, brain-derived extracellular vesicles are released into circulation where they induce a hypercoagulable state that rapidly turns into consumptive coagulopathy. VWF released from injured endothelial cells binds to these extracellular vesicles to enhance their activity in promoting coagulopathy and increasing endothelial permeability. However, there are numerous gaps in our knowledge of VWF following injury, providing a platform for further investigation.
Clinical Magnetoencephalography Practice in the United States Ten Years Later: A Survey-Based Reappraisal
Authors: Bagić Anto I. , Burgess Richard C. 
Published: November 2020

Purpose:Broader utilization of magnetoencephalography (MEG) and optimization of clinical practice remain strategic goals of the American Clinical Magnetoencephalography Society. Despite the implementation of the first MEG Clinical Practice Guidelines, clinical adoption has been less than expected, prompting a reassessment.Methods:Twenty-five clinical MEG centers were invited to participate anonymously in a survey of clinical practice.Results:Centers (N= 18) mostly operated within an academic medical center (10/18), were owned by the “hospital” (10/18), associated with a level 4 National Association of Epilepsy center (15/18), and directed by neurologists (10/18). A total of 873 (median 59) epilepsy studies, 1,179 evoked fields (of all types), and 1,607 (median 30) research MEG studies were reported. Fourteen of 17 centers serve children (median 35%), but only 5 of 14 sedate children for MEG. All (N= 14) centers record EEG simultaneous with MEG, and 57% used dipole source localization. The median reporting time for epilepsy studies was 12 and 10 days for presurgical mapping studies. Most (12/14) were favorable toward the Clinical Practice Guidelines and “formalized certification” but were against mandating the latter.Conclusions:A plateau in MEG volumes suggests that MEG has not become a part of the standard of care, and correspondingly, the Clinical Practice Guidelines appeared to have had little impact on clinical practice. The American Clinical Magnetoencephalography Society must continue to engage magnetoencephalographers, potential referrers, and vendors.
Effect of control measure on the development of new COVID-19 cases through SIR model simulation
Authors: L. Clara , Liu Fei 
Published: November 2020

AbstractIn December 2019, the outbreak of corona virus disease, also known as COVID-19, was first reported in Wuhan, China [1]. Within only one month, the disease quickly spread to the United States through the transmission of respiratory droplets released when an infected individual sneezes or coughs [2]. Throughout the course of 9 months, the US reported over 8 million cases and 204,000 deaths, affecting the daily lives of American citizens [3]. As trends in corona virus cases are changing daily, it’s important to monitor these trends and observe the causes for the increase and decrease in new cases. The trends in new corona virus cases in the US as well as New Jersey are simulated using a modified Susceptible-Infected-Recovered (SIR) model. The new case graphs from the simulations reflect the new case trends in both the US and New Jersey and can be used to understand the mechanism behind the rates of corona virus infection as well as predict future corona virus trends. Comparisons between the results of the simulations and observed data show the effectiveness of control measures such as quarantine, physical distancing, and wearing masks. The extended time period of control measures taken in New Jersey led to a gradual decline in new cases reported daily while the US new cases showed a second wave of growth after control measures were implemented to a lesser extent.