bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple tubostomy and its outcome for blunt duodenal injury
Authors: Pandit Narendra , Yadav Tek Narayan , Awale Laligen , Adhikary Shailesh 
Published: May 2020

Introduction: Blunt duodenal injury in an uncommon form of abdominal injuries, which comprises less than 5% of all injuries. The diagnosis and management are challenging, because of delays in diagnosis due to subtle signs and symptoms in its early stage of presentation. Primary repair along with triple tubostomy (gastrostomy, retrograde duodenostomy and feeding jejunostomy) is a simple and safe method of damage control surgery in this group of patients. This study aims to report our experience in the management of this uncommon procedure.
Methods: This is a retrospective analysis of the patients undergoing triple tubostomy (TT) for blunt duodenal injury at the Department of Surgery, B.P.Koirala Institute of Health Sciences (BPKIHS), Dharan, over a three and half years. The study included demographics, clinical profile, length of hospital stay, postoperative morbidity (duodenal fistula), rate and timing of spontaneous closure of fistula and mortality.
Results: Eleven (6.7%) patients out of 164 blunt trauma abdomen had sustained a duodenal injury. Eight patients who underwent TT were included in the study. The mean age of the patient was 31.8 years (range: 18-67), with a male: female ratio of 3:1. The mean time to trauma and presentation was 4.25 days. The most common site of injury was the second part of the duodenum (87.5%), AAST grade III was seen in 62.5%, two (25%) patients were in shock at presentation. Eight patients required primary closure with triple tubostomy. Postoperatively, all patients had a duodenal fistula, which closed spontaneously in 6 (75%) patients at a mean duration of 17 days, with a mean postoperative length of hospital stay of 33.5 days. The remaining two (25%) patients died of an active fistula.
Conclusion: Blunt duodenal trauma, when presented late can be managed with primary closure and triple tubostomy with acceptable postoperative outcomes.
Visão dos alunos bolsistas do PIBID/ Matemática sobre o que é ser professor e o seu papel no Programa
Authors: Costa Roberta , Prata-Linhares Martha Maria , Pompeu Carla Cristina 
Published: May 2020

A proposta deste trabalho é apresentar reflexões de um grupo de alunos bolsistas do Programa Institucional de Bolsas de Iniciação à Docência (PIBID) sobre o que é ser professor e qual é o seu papel no PIBID. Sete alunos bolsistas do PIBID/ Matemática de uma universidade localizada no Triângulo Mineiro foram convidados a participar de um encontro onde realizou-se uma entrevista coletiva com perguntas abertas. Para a análise dos dados utilizamos o software IRaMuTeQ (Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires). A análise dos dados trouxe à tona aspectos como a importância do trabalho do professor supervisor como coformador desses alunos bolsistas, a valorização da formação integrada, da transformação didática, da atitude e do desenvolvimento profissional dos alunos bolsistas.
THE INFLUENCE OF ASH MICROSPHERES ON CERAMIC PROPERTIES
Authors: Skripnikova N. K. , Grigorevskaya D. K. , Semenovykh M. A. 
Published: May 2020

The paper deals with the problem of producing heat-insulating ceramic bricks using ash microspheres. The influence of the main technological factors on the ceramic material properties and physicochemical processes in composition preparation is investigated. Clay raw materials of the Verkhovaya deposit of the Tomsk region and ash hollow microspheres of the Belovskaya power plant are studied. It is found that 80 % ash microspheres in the mixture composition reduces the average density by 50 % and water absorption by 28 %; and increases thermal conductivity by 50 %, average compressive strength by 22 % and flexural strength by 30 %. According to the Xray analysis, laboratory samples represent the following crystalline phases: quartz, gehlenite, albite, kyanite, anorthite- and mullite-like compounds. The presence of these minerals in the composition improves the strength properties of the resulting calcined compositions. Microscopy observations show that the structure of the samples is mostly uniform, with a significant number of closed and half-closed pores, that are difficult to reach and inaccessible to water. This factor significantly affects the frost resistance of the product, causing stress relaxation arising from water frozen in pores. As a result, the obtained laboratory samples have the improved thermophysical quality.
TECHNOLOGY IMPROVEMENT OF HIGH-DISPERSIVE METALLIC IRON POWDERS BASED ON SEDIMENTS OF IRON REMOVAL STATION
Authors: Maksimov L. I. , Mirinov V. V. 
Published: May 2020

Sediments from iron removal stations are a source of environmental pollution. It is necessary to find effective and eco-friendly methods of sediment disposal. The paper investigates the properties of iron-containing sediment in order to develop a technology for its further utilization. It is shown that sediments from the iron removal station of Velizhansky water intake have a stable chemical composition with about 70 % Fe2O3, and a stable particle size distribution, i.e. 20 μm for ≈ 87 % of particles. These parameters allow developing a flow chart for iron reduction in heated carbon monoxide. The involvement of sediments from iron removal stations in the high-dispersive metallic iron powder production eliminates the sediment deposit at landfills or storage tanks and creates a new raw material base for additive technologies.
Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics
Authors: Tsolinas Rachel E. , Burke John F. , DiGiorgio Anthony M. , Thomas Leigh H. , Duong-Fernandez Xuan , Harris Mark H. , Yue John K. , Winkler Ethan A. , Suen Catherine G. , Pascual Lisa U. , Ferguson Adam R. , Huie J. Russell , Pan Jonathan Z. , Hemmerle Debra D. , Singh Vineeta , Torres-Espin Abel , Omondi Cleopa , Kyritsis Nikos , Haefeli Jenny , Weinstein Philip R. , de Almeida Neto Carlos A. , Kuo Yu-Hung , Taggard Derek , Talbott Jason F. , Whetstone William D. , Manley Geoffrey T. , Bresnahan Jacqueline C. , Beattie Michael S. , Dhall Sanjay S. 
Published: May 2020

OBJECTIVETraumatic spinal cord injury (SCI) is a dreaded condition that can lead to paralysis and severe disability. With few treatment options available for patients who have suffered from SCI, it is important to develop prospective databases to standardize data collection in order to develop new therapeutic approaches and guidelines. Here, the authors present an overview of their multicenter, prospective, observational patient registry, Transforming Research and Clinical Knowledge in SCI (TRACK-SCI).METHODSData were collected using the National Institute of Neurological Disorders and Stroke (NINDS) common data elements (CDEs). Highly granular clinical information, in addition to standardized imaging, biospecimen, and follow-up data, were included in the registry. Surgical approaches were determined by the surgeon treating each patient; however, they were carefully documented and compared within and across study sites. Follow-up visits were scheduled for 6 and 12 months after injury.RESULTSOne hundred sixty patients were enrolled in the TRACK-SCI study. In this overview, basic clinical, imaging, neurological severity, and follow-up data on these patients are presented. Overall, 78.8% of the patients were determined to be surgical candidates and underwent spinal decompression and/or stabilization. Follow-up rates to date at 6 and 12 months are 45% and 36.3%, respectively. Overall resources required for clinical research coordination are also discussed.CONCLUSIONSThe authors established the feasibility of SCI CDE implementation in a multicenter, prospective observational study. Through the application of standardized SCI CDEs and expansion of future multicenter collaborations, they hope to advance SCI research and improve treatment.
Altered corticospinal microstructure and motor cortex excitability in gliomas: an advanced tractography and transcranial magnetic stimulation study
Authors: Mirchandani Ayesha Sunil , Beyh Ahmad , Lavrador José Pedro , Howells Henrietta , Dell’Acqua Flavio , Vergani Francesco 
Published: May 2020

OBJECTIVE
This prospective case-control study was conducted to examine whether spherical deconvolution (SD) can unveil microstructural abnormalities in the corticospinal tract (CST) caused by IDH-mutant gliomas. To determine the significance of abnormal microstructure, the authors investigated the correlation between diffusion parameters and neurophysiological data collected with navigated transcranial magnetic stimulation (nTMS).

METHODS
Twenty participants (10 patients and 10 healthy controls) were recruited. Diffusion-weighted images were acquired on a 3-T MRI scanner using a cardiac-gated single-shot spin echo echo-planar imaging multiband sequence (TE 80 msec, TR 4000 msec) along 90 diffusion directions with a b-value of 2500 sec/mm2 (FOV 256 × 256 mm). Diffusion tensor imaging tractography and SD tractography were performed with deterministic tracking. The anterior portion of the ipsilateral superior peduncle and the precentral gyrus were used as regions of interest to delineate the CST. Diffusion indices were extracted and analyzed for significant differences between hemispheres in patients and between patient and control groups. A navigated brain stimulation system was used to deliver TMS pulses at hotspots at which motor evoked potentials (MEPs) for the abductor pollicis brevis, first digital interosseous, and abductor digiti minimi muscles are best elicited in patients and healthy controls. Functional measurements such as resting motor threshold (rMT), amplitude of MEPs, and latency of MEPs were noted. Significant differences between hemispheres in patients and between patients and controls were statistically analyzed. The Spearman rank correlation was used to investigate correlations between diffusion indices and functional measurements.

RESULTS
The hindrance modulated orientational anisotropy (HMOA), measured with SD tractography, is lower in the hemisphere ipsilateral to glioma (p = 0.028). The rMT in the hemisphere ipsilateral to a glioma is significantly greater than that in the contralateral hemisphere (p = 0.038). All measurements contralateral to the glioma, except for the mean amplitude of MEPs (p = 0.001), are similar to those of healthy controls. Mean diffusivity and axial diffusivity from SD tractography are positively correlated with rMT in the hemisphere ipsilateral to glioma (p = 0.02 and 0.006, respectively). The interhemispheric difference in HMOA and rMT is correlated in glioma patients (p = 0.007).

CONCLUSIONS
SD tractography can demonstrate microstructural abnormality within the CST of patients with IDH1-mutant gliomas that correlates to the functional abnormality measured with nTMS.
Predictors of 30-day hospital readmission after mechanical thrombectomy for acute ischemic stroke
Authors: Mouchtouris Nikolaos , Al Saiegh Fadi , Valcarcel Breanna , Andrews Carrie E. , Fitchett Evan , Nauheim David , Moskal David , Herial Nabeel , Jabbour Pascal , Tjoumakaris Stavropoula I. , Sharan Ashwini D. , Rosenwasser Robert H. , Gooch M. Reid 
Published: May 2020

OBJECTIVE
The 30-day readmission rate is of increasing interest to hospital administrators and physicians, as it is used to evaluate hospital performance and is associated with increased healthcare expenditures. The estimated yearly cost to Medicare of readmissions is $17.4 billion. The Centers for Medicare and Medicaid Services therefore track unplanned 30-day readmissions and institute penalties against hospitals whose readmission rates exceed disease-specific national standards. One of the most important conditions with potential for improvement in cost-effective care is ischemic stroke, which affects 795,000 people in the United States and is a leading cause of death and disability. Recent widespread adoption of mechanical thrombectomy has revolutionized stroke care, requiring reassessment of readmission causes and costs in this population.

METHODS
The authors retrospectively analyzed a prospectively maintained database of stroke patients and identified 561 patients who underwent mechanical thrombectomy between 2010 and 2019 at the authors’ institution. Univariate and multivariate analyses were conducted to identify clinical variables and comorbidities related to 30-day readmissions in this patient population.

RESULTS
Of the 561 patients, 85.6% (n = 480) survived their admission and were discharged from the hospital to home or rehabilitation, and 8.8% (n = 42/480) were readmitted within 30 days. The median time to readmission was 10.5 days (IQR 6.0–14.3). The most common reasons for readmission were infection (33.3%) and acute cardiac or cerebrovascular events (19% and 20%, respectively). Multivariate analysis showed that hypertension (p = 0.030; OR 2.72) and length of initial hospital stay (p = 0.040; OR 1.032) were significantly correlated with readmission within 30 days, while hemorrhagic conversion (grades 3 and 4) approached significance (p = 0.053; OR 2.23). Other factors, such as unfavorable outcome at discharge, history of coronary artery disease, and discharge destination, did not predict readmission.

CONCLUSIONS
The study data demonstrate that hypertension, length of hospital stay, and hemorrhagic conversion were predictors of 30-day hospital readmission in stroke patients after mechanical thrombectomy. Infection was the most common cause of 30-day readmission, followed by cardiac and cerebrovascular diagnoses. These results therefore may serve to identify patients within the stroke population who require increased surveillance following discharge to reduce complications and unplanned readmissions.
High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model
Authors: Sandberg David I. , Kharas Natasha , Yu Bangning , Janssen Christopher F. , Trimble Amanda , Ballester Leomar Y. , Patel Rajan , Mohammad Afroz S. , Elmquist William F. , Sirianni Rachael W. 
Published: May 2020

OBJECTIVEChemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates.METHODSFour rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In group I (n = 2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess CSF distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for 5 consecutive days. Serial CSF and serum panobinostat levels were measured. In group II (n = 2), fourth-ventricle catheters were connected to a subcutaneously placed port for subsequent long-term infusions. Four cycles of MTX110, each consisting of 5 daily infusions (0.5 ml of 300 μM panobinostat solution), were administered over 8 weeks. Animals underwent detailed neurological evaluations, MRI scans, and postmortem histological analyses.RESULTSNo neurological deficits occurred after intraventricular MTX110 infusions. MRI scans showed catheter placement within the fourth ventricle in all 4 animals, with extension to the cerebral aqueduct in 1 animal and into the third ventricle in 1 animal. There were no MRI signal changes in the brainstem, cerebellum, or elsewhere in the brains of any of the animals. Histologically, normal brain cytoarchitecture was preserved with only focal mild postsurgical changes in all animals. Panobinostat was undetectable in serum samples collected 2 and 4 hours after infusions in all samples in both groups. In group I, the mean peak panobinostat level in the fourth-ventricle CSF (6242 ng/ml) was significantly higher than that in the lumbar CSF (9 ng/ml; p < 0.0001). In group II, the mean peak CSF panobinostat level (11,042 ng/ml) was significantly higher than the mean trough CSF panobinostat level (33 ng/ml; p < 0.0001).CONCLUSIONSMTX110 can be safely infused into the fourth ventricle in nonhuman primates at supratherapeutic doses. Postinfusion CSF panobinostat levels peak immediately in the fourth ventricle and then rapidly decrease over 24 hours. Panobinostat is detectable at low levels in CSF measured from the lumbar cistern up to 4 hours after infusions. These results will provide background data for a pilot clinical trial in patients with recurrent medulloblastoma.
C2 medial pedicle screw: a novel “in-out-in” technique as an alternative option for posterior C2 fixation in cases with a narrow C2 isthmus
Authors: Du Yue-Qi , Yin Yi-Heng , Qiao Guang-Yu , Yu Xin-Guang 
Published: May 2020

OBJECTIVEThe authors describe a novel “in-out-in” technique as an alternative option for posterior C2 screw fixation in cases that involve narrow C2 isthmus. Here, they report the preliminary radiological and clinical outcomes in 12 patients who had a minimum 12-month follow-up period.METHODSTwelve patients with basilar invagination and atlantoaxial dislocation underwent atlantoaxial reduction and fixation. All patients had unilateral hypoplasia of the C2 isthmus that prohibited insertion of pedicle screws. A new method, the C2 medial pedicle screw (C2MPS) fixation, was used as an alternative. In this technique, the inner cortex of the narrow C2 isthmus was drilled to obtain space for screw insertion, such that the lateral cortex could be well preserved and the risk of vertebral artery injury could be largely reduced. The C2MPS traveled along the drilled inner cortex into the anterior vertebral body, achieving a 3-column fixation of the axis with multicortical purchase.RESULTSSatisfactory C2MPS placement and reduction were achieved in all 12 patients. No instance of C2MPS related vertebral artery injury or dural laceration was observed. There were no cases of implant failure, and solid fusion was demonstrated in all patients.CONCLUSIONSThis novel in-out-in technique can provide 3-column rigid fixation of the axis with multicortical purchase. Excellent clinical outcomes with low complication rates were achieved with this technique. When placement of a C2 pedicle screw is not possible due to anatomical constraints, the C2MPS can be considered as an efficient alternative.
Pengaruh Kompetensi Kepribadian terhadap Motivasi Kerja Guru Pendidikan Anak Usia Dini
Authors: Sofia Ari , Annisayulistia  
Published: May 2020

Penelitian ini bertujuan untuk mengetahui: (1) kompetensi kepribadian guru PAUD dalam program PPG, (2) motivasi kerja guru PAUD dalam program PPG, (3) pengaruh kompetensi kepribadian terhadap motivasi kerja guru PAUD dalam program PPG; dan (4) seberapa besar pengaruh kompetensi kepribadian terhadap motivasi kerja guru PAUD dalam program PPG Universitas Lampung tahun ajaran 2019/2020. Penelitian ini merupakan penelitian expost-facto dengan pendekatan kuantitatif. Populasi dalam penelitian ini yaitu seluruh guru PAUD peserta program PPG Universitas Lampung. Teknik pengumpulan data menggunakan angket kompetensi kepribadian dan angket motivasi kerja. Pengujian hipotesis menggunakan uji prasyarat analisis menggunakan uji normalitas, uji linearitas, analisis regresi linear sederhana, dan koefisien diterminan. Hasil penelitian menunjukkan bahwa: (1) kompetensi kepribadian gu,ru PAUD dalam program PPG berada pada kategori “cukup baik” ditunjukkan dengan nilai rata-rata 84,14, (2) motivasi kerja guru PAUD dalam program PPG berada pada kategori “baik” ditunjukkan dengan nilai rata-rata 83,86, (3) terdapat pengaruh positif dan signifikan kompetensi kepribadian terhadap motivasi kerja guru PAUD dalam Program PPG, ditunjukkan dengan nilai t hitung 2,130 > t tabel 1,701,dan (4) kontribusi kompetensi kepribadian terhadap motivasi kerja guru PAUD dalam Program PPG sebesar 14,9%, sisanya 85,1% ditentukan oleh faktor lain.
Kata Kunci: kompetensi kepribadian, motivasi kerja
Pengelolaan Kelas pada Model Pembelajaran Kelompok pada Anak Usia 5-6 Tahun di TK IT Al- Mahira
Authors: Suharni  , Sri Wahyuni  , Salmah  
Published: May 2020

Penelitian ini bertujuan untuk mengetahui hubungan pengelolaan kelas terhadap model pembelajaran kelompok anak usia dini di TK IT Al- Mahira. Metode yang digunakan adalah Pendekatan Kuantitatif Korelasional. Penelitian ini dilaksanakan di TK IT Al- Mahira. Pengambilan sampel dilakukan dengan Random Sampling dengan jumlah 30 Anak. Variabel penelitian terdiri dari variabel X (pengelolaan kelas) dan Y (model pembelajaran kelompok). Teknik pengumpulan data yang digunakan adalah dengan menyebarkan angket berupa abjad atau a, b dan c dalam setiap gambar kepada siswa sebagai responden. Metode yang digunakan adalah korelasi dengan taraf 5%. Dari hasil perhitungan dengan menggunakan SPSS 23 diperoleh signifikan sebesar 0,072. Dengan demikian Ha yang menyatakan adanya pengaruh antara pengelolaan kelas terhadap model pembelajaran kelompok ditolak dan sebaliknya Ho yang menyatakan tidak adanya pengaruh antara pengelolaan kelas terhadap model pembelajaran kelompok diterima. Maka dapat ditarik kesimpulan bahwa tidak terdapat korelasi pengelolaan kelas terhadap model pembelajaran kelompok anak usia dini di TK IT Al- Mahira. Artinya, model pembelajaran kelompok yang baik belum tentu pengelolaan kelasnya kurang menarik dan sebaliknya model pembelajaran kelompok yang kurang baik belum tentu pengelolaan kelasnya menarik.
Os Caminhos das Políticas Públicas de Interiorização da Educação Superior na Macrorregião do Cariri.
Authors: Campelo Calebe Lucas Feitosa , Ferreira da Silva Maria Lúcia , Vitorino Pereira Marcos Ítalo , Santana Mateus Pereira 
Published: May 2020

A partir dos anos 2000, na região do Cariri, há maior intensificação e diversificação das atividades socioeconômicas. Isso atribui novos contornos e configurações à região. A forte presença de instituições de ensino superior também é sentida nesse período. Nesse viés, o presente estudo tem o objetivo de analisar de forma crítica o fenômeno de interiorização da Educação Superior na macrorregião caririense, região esta que vem passando por processo de elevado crescimento educacional e econômico, realizando um recorte dimensional dos anos 2000 até 2015. Para isto foi realizada uma pesquisa bibliográfica-documental, tendo como baliza estudiosos que tratam da expansão do ensino superior brasileiro e para a sistematização do estudo foi utilizada uma abordagem quali-quantitativa a qual buscou como referência o censo do ensino superior brasileiro colhido e documentado a partir do Instituto Nacional de Estudos e Pesquisas (INEP), bem como o último censo demográfico do Instituto Brasileiro de Geografia e Estatística (IBGE) .Com efeito, o trabalho apresenta um panorama dos contributos que as políticas públicas deram para a interiorização do Ensino Superior no cariri, assim como os impactos para o desenvolvimento regional e formação de um dos maiores polos universitários do interior do Ceará.Com efeito, a pesquisa ainda aponta os entraves que ainda existem para a democratização da Educação Superior, não somente no Cariri, mas a nível nacional. As análises realizadas nas discussões do pesquisa demonstram o contraste que foi criado entre o discurso de democratização da Educação Superior e o que foi efetivado na prática, demonstrando os resultados da parceria público-privado iniciado nos governos de Fernando Henrique Cardoso e continuados pelos governos subsequentes que com as reformas e parcerias realizadas não conseguiram garantir educação pública a nível de ensino superior gratuita a toda a população, sendo fundamental a reformulação e consequente analise das políticas públicas aplicadas.