bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature
Authors: Yoo Stella K. , Strickland Ben A. , Zada Gabriel , Bian Shelly X. , Garsa Adam , Ye Jason C. , Yu Cheng , Weiss Martin H. , Wrobel Bozena B. , Giannotta Steven , Chang Eric L. 
Published: January 2020

Abstract
Introduction Chordomas are locally destructive neoplasms characterized by appreciable recurrence rates after initial multimodality treatment. We examined the outcome of salvage treatment in recurrent/progressive skull base chordomas.
Methods This is a retrospective review of recurrent/progressive skull base chordomas at a tertiary urban academic medical center. The outcomes evaluated were overall survival, progression-free survival (PFS), and incidence of new toxicity.
Results Eighteen consecutive patients who underwent ≥1 course of treatment (35.3% salvage surgery, 23.5% salvage radiation, and 41.2% both) were included. The median follow-up was 98.6 months (range 16–215 months). After initial treatment, the median PFS was 17.7 months (95% confidence interval [CI]: 4.9–22.6 months). Following initial therapy, age ≥ 40 had improved PFS on univariate analysis (p = 0.03). All patients had local recurrence, with 15 undergoing salvage surgical resections and 16 undergoing salvage radiation treatments (mostly stereotactic radiosurgery [SRS]). The median PFS was 59.2 months (95% CI: 4.0–99.3 months) after salvage surgery, 58.4 months (95% CI: 25.9–195 months) after salvage radiation, and 58.4 months (95% CI: 25.9.0–98.4 months) combined. Overall survival for the total cohort was 98.7% ± 1.7% at 2 years and 92.8% ± 5.5% at 5 years. Salvage treatments were well-tolerated with two patients (11%) reporting tinnitus and one patient each (6%) reporting headaches, visual field deficits, hearing loss, anosmia, dysphagia, or memory loss.
Conclusion Refractory skull base chordomas present a challenging treatment dilemma. Repeat surgical resection or SRS seems to provide adequate salvage therapy that is well-tolerated when treated at a tertiary center offering multimodality care.
Pain and Psychological Distress: Effect of Microvascular Decompression on Sleep Disorders and Obsessions in Trigeminal Neuralgia
Authors: Wang Yanglingxi , Sun Kai , Zhang Wenling , Zhang HaiTao , Wang Chong 
Published: January 2020

Abstract
Objective This study was aimed to investigate the effects of microvascular decompression (MVD) on sleep disorders and obsessions in trigeminal neuralgia.
Methods Clinical data from 115 patients with trigeminal neuralgia treated with MVD from August 1, 2017 to May 31, 2018 at Jining First People's Hospital were analyzed retrospectively. The preoperative and postoperative risk factors for sleep disorders and obsessions, as well as the effects of MVD on sleep disorders and obsessions, were examined.
Results In 115 patients, there were significant differences in preoperative sleep disorders associated with sex, monthly household income, pain in multiple branches, visual analog scale (VAS) score, and Self-Rating Depression Scale (SDS) score (p < 0.05). Preoperative obsessions were significantly different according to age, gender, pain in multiple branches, monthly household income, VAS score, and Self-Rating Anxiety Scale (SAS) score groups (p < 0.05). A 1-year recurrence was positively correlated with sleep disturbance (odds ratio = 3.829) and obsessions (odds ratio = 4.507). In addition, the results revealed a negative correlation between the manipulation of trigeminal neuralgia and postoperative sleep disorders (B ≥ 1.043). Moreover, there was a significant difference in sleep disorders and obsessions before and 1 year after MVD (p < 0.05).
Conclusion For patients with trigeminal neuralgia, pain caused by sleep and obsession disorders should be examined early to identify an effective solution. Moreover, MVD, as a first treatment, is valuable for improving the physiological and psychological prognosis of patients.
Interplay of network structure and neighbour performance in user innovation
Authors: Yang Kunhao , Fujisaki Itsuki , Ueda Kazuhiro 
Published: January 2020

AbstractPrevious studies showed that regular users have become an important source of innovation (called user innovation). Previous studies also suggested that two factors have significant impacts on user innovation: the social network structure of the users and neighbours’ innovation performance (neighbours mean users having interactions with the focal user). However, in these studies, the influence of the two factors were only discussed separately, and it remained unclear whether these two factors interdependently affected a focal user’s innovation. To examine the interplay between the network structure and the neighbours’ innovation performance, we harnessed data sets from “Idea Storm”, which collects data on user network and idea submission. Through panel regression analyses, we found that—within an open-network structure—the higher innovation performance of neighbours has a larger positive impact on the focal user’s innovation ability. Conversely, in an enclosed network structure, neighbours’ higher performance has a larger negative impact on the focal user’s innovation ability. Our findings filled an important gap in understanding the interplay between the network structure and the neighbours’ performance in user innovation. More broadly, these results suggested that the interplay between the neighbours and the network structures merits attention that even goes beyond user innovation.
LINGO1 is a regulatory subunit of large conductance, Ca
2+
-activated potassium channels
Authors: Dudem Srikanth , Large Roddy J. , Kulkarni Shruti , McClafferty Heather , Tikhonova Irina G. , Sergeant Gerard P. , Thornbury Keith D. , Shipston Michael J. , Perrino Brian A. , Hollywood Mark A. 
Published: January 2020

Significance
Large conductance calcium-activated potassium (BK) channels are ubiquitously expressed and alter cellular excitability. These channels are formed by four pore-forming α subunits whose biophysical and pharmacological properties are modulated by regulatory β and γ subunits. LINGO1 is a protein, previously shown to be upregulated in both Parkinson’s disease and Essential Tremor. Consequently, we investigated its effects on BK channels and demonstrate that LINGO1 associates with these channels in human cerebellum. LINGO1 causes BK channels to inactivate and to open at more negative potentials. Furthermore, coexpression of BK with LINGO1 also led to a reduction in BK channels in the membrane. Our data support the idea that LINGO1 is a regulatory subunit of BK channels.
限定性和汉语主句
Authors: Sybesma Rint 
Published: January 2020

摘要本文通过对含有光杆动宾结构和体标记的汉语非自足句的考察，提出这些句子不合法的原因在于它们都是非限定句。在对非限定句做出的功能定义的基础上，本文指出事件句的时间理解需要三类抽象“时间”，即事件时间（Situation Time, SitT），声称/指称时间（Topic/Reference Time, TT），和说话时间（Utterance Time, UT）。在此基础上，我们进一步指出限定句的骨架的必有成分包括 CP, TP, AspP 和 VP（即 VP-e）。因此，本文讨论的句子之所以不合法，可以归因于骨架的不完整。同时，本文也检验了几种修补该类句子的手段，指出其目的多是加强了谓语的潜在的事件性，以满足限定事件句骨架的需要。由此，本文提出了一种分析汉语非自足句的新的理论框架。
Hotel management’s attempts at repairing customers’ trust
Authors: Ho Victor 
Published: January 2020

Abstract
The present study explores the discursive practice of the hospitality industry in addressing competence-based,
benevolence-based, and integrity-based accusations of trust violation made by dissatisfied customers on TripAdvisor. Authentic
negative online reviews written by dissatisfied customers and the corresponding responses by hotel management downloaded directly
from TripAdvisor are analyzed qualitatively with Nvivo10. Results show that hotel management has the strongest preference for
apology, followed by implicit denial and then explicit denial when dealing with the three different types of accusations of trust
violation. The findings will enhance our understanding of trust and its repair, and benefit hospitality practitioners responsible
for handling online criticisms and complaints.
Characterization of cold-tolerant trehalose-6-phosphate synthase from the deep-sea bacterium Microbacterium sediminis YLB-01
Authors: Tang Xixiang , Yi Zhiwei , Xu Xiashutong , Xu Rufang , Huang Ping , Yu Libo 
Published: January 2020

Abstract
A gene encoding the enzyme trehalose-6-phosphate synthase (TPS), which is part of the TPS trehalose synthesis pathway, was cloned from the deep-sea psychrotolerant bacterium Microbacterium sediminis YLB-01 and expressed in Escherichia coli BL21. The exogenously expressed TPS exhibited highest similarity (80.93% identity) to Microbacterium sp. TPS. The purified recombinant TPS was cold-tolerant, with low thermostability. The optimum temperature for TPS activity was 40°C, and the enzyme retained 72.6% of its maximal activity at 4°C. The optimum pH was 7.5. TPS activity was cation-dependent, with Mg2+, Co2+, or Ba2+ being essential for maximum activity. The kinetic constants of the recombinant TPS reaction rates confirmed that it was cold-tolerant. Molecular dynamics analysis showed that TPS was more flexible (0.8741Å) at 4°C than 1GZ5, its homolog in the mesophilic bacterium E. coli, and superposition of the 3D enzyme structures supported this.
Metallic alloys at the edge of complexity: structural aspects, chemical bonding and physical properties*
Authors: Ovchinnikov Alexander , Smetana Volodymyr , Mudring Anja-Verena 
Published: January 2020

Abstract
Complex metallic alloys belong to the vast family of intermetallic compounds and are hallmarked by extremely large unit cells and, in many cases, extensive crystallographic disorder. Early studies of complex intermetallics were focusing on the elucidation of their crystal structures and classification of the underlying building principles. More recently, ab initio computational analysis and detailed examination of the physical properties have become feasible and opened new perspectives for these materials. The present review paper provides a summary of the literature data on the reported compositions with exceptional structural complexity and their properties, and highlights the factors leading to the emergence of their crystal structures and the methods of characterization and systematization of these compounds.
A new AI-surrogate model for dynamics analysis of a magnetorheological damper in the semi-active seat suspension
Authors: Liu Xinhua , Wang Ningning , Wang Kun , Chen Shumei , Sun Shuaishuai , Li Zhixiong , Li Weihua 
Published: January 2020

AbstractThis paper aims to develop a surrogate model for dynamics analysis of a magnetorheological damper (MRD) in the semi-active seat suspension system. An improved fruit fly optimization algorithm (IFOA) which enhances the global search capability of the original FOA is proposed to optimize the structure of a back propagation neural network (BPNN) in establishing the surrogate model. An MRD platform was fabricated to generate experimental data to feed the IFOA-BPNN model. Intrinsic patterns about the MRD dynamics behind the datasets have been discovered to establish a reliable MRD surrogate model. The outputs of the surrogate model demonstrate satisfactory dynamics characteristics in consistence with the experimental results. Moreover, the performance of the IFOA-BPNN based surrogate model was compared with that produced by the BPNN based, genetic algorithm-BPNN based, and FOA-BPNN based surrogate models. The comparison result shows better tracking capacity of the proposed method on the hysteresis behaviors of the MRD. As a result, the newly developed surrogate model can be used as the basis for advanced controller design of the semi-active seat suspension system.
Rapid and transient enhancement of thalamic information transmission induced by vagus nerve stimulation
Authors: Rodenkirch Charles , Wang Qi 
Published: January 2020

Abstract

Objective. Vagus nerve stimulation (VNS) has been FDA-approved as a long-term, therapeutic treatment for multiple disorders, including pharmacoresistant epilepsy and depression. Here we elucidate the short-term effects of VNS on sensory processing. Approach. We employed an information theoretic approach to examine the effects of VNS on thalamocortical transmission of sensory-related information along the somatosensory pathway. Main results. We found that VNS enhanced the selectivity of the response of thalamic neurons to specific kinetic features in the stimuli, resulting in a significant increase in the efficiency and rate of stimulus-related information conveyed by thalamic spikes. VNS-induced improvements in thalamic sensory processing coincided with a decrease in thalamic burst firing. Importantly, we found VNS-induced enhancement of sensory processing had a rapid onset and offset, completely disappearing one minute after cessation of VNS. The timescales of these effects indicate against an underlying mechanism involving long-term neuroplasticity. We found several patterns of VNS (tonic, standard duty-cycle, and fast duty-cycle) all induced similar improvements in sensory processing. Under closer inspection we noticed that due to the fast timescale of VNS effects on sensory processing, standard duty-cycle VNS induced a fluctuating sensory processing state which may be sub-optimal for perceptual behavior. Fast duty-cycle VNS and continuous, tonic VNS induced quantitatively similar improvements in thalamic information transmission as standard duty-cycle VNS without inducing a fluctuating thalamic state. Further, we found the strength of VNS-induced improvements in sensory processing increased monotonically with amplitude and frequency of VNS. Significance. These results demonstrate, for the first time, the feasibility of utilizing specific patterns of VNS to rapidly improve sensory processing and confirm fast duty-cycle and tonic patterns as optimal for this purpose, while showing standard duty-cycle VNS causes non-optimal fluctuations in thalamic state.
Projected effects of 1.5 °C and 2 °C global warming levels on the intra-seasonal rainfall characteristics over the Greater Horn of Africa
Authors: Gudoshava Masilin , Misiani Herbert O , Segele Zewdu T , Jain Suman , Ouma Jully O , Otieno George , Anyah Richard , Indasi Victor S , Endris Hussen Seid , Osima Sarah , Lennard Christopher , Zaroug Modathir , Mwangi Emmah , Nimusiima Alex , Kondowe Alfred , Ogwang Bob , Artan Guleid , Atheru Zachary 
Published: January 2020

AbstractThis study examines the effects of 1.5 °C and 2 °C global warming levels (GWLs) on intra-seasonal rainfall characteristics over the Greater Horn of Africa. The impacts are analysed based on the outputs of a 25-member regional multi-model ensemble from the Coordinated Regional Climate Downscaling Experiment project. The regional climate models were driven by Coupled Model Intercomparison Project Phase 5 Global Climate Models for historical and future (RCP8.5) periods. We analyse the three major seasons over the region, namely March–May, June–September, and October–December. Results indicate widespread robust changes in the mean intra-seasonal rainfall characteristics at 1.5 °C and 2 °C GWLs especially for the June–September and October–December seasons. The March–May season is projected to shift for both GWL scenarios with the season starting and ending early. During the June–September season, there is a robust indication of delayed onset, reduction in consecutive wet days and shortening of the length of rainy season over parts of the northern sector under 2 °C GWL. During the October–December season, the region is projected to have late-onset, delayed cessation, reduced consecutive wet days and a longer season over most of the equatorial region under the 2 °C GWL. These results indicate that it is crucial to limit the GWL to below 1.5 °C as the differences between the 1.5 °C and 2 °C GWLs in some cases exacerbates changes in the intra-seasonal rainfall characteristics over the Greater Horn of Africa.
The energy and ecological performance of the hot water boiler burning linden bark and wood briquettes
Authors: Lyubov V K , Popov A N , Popova E I 
Published: January 2020

Abstract
The North-West of Russia possesses huge wood resources reserves, therefore the issues of the most efficient use of wood biomass are relevant for this region. The implication of wood biofuels into fuel and energy budget provides an opportunity to reduce the negative impact of power industry facilities on the environment and preserve the potential of non-renewable fuels for future generations. An effective way of the complex solution of energy and ecological problems, while providing heating loads for consumers, is the use of modern devices operating on solid biofuel. Technical analysis of foreign and domestic high-performance heating units has great importance. The aim of the research is an evaluation of energy and ecological performance of the Firematic 60 hot water boiler burning bark of linden, briquettes from wood sanding dust and sawdust of plywood processing, as well as briquettes obtained by pressing softwood sawdust and shavings. The paper presents thermotechnical characteristics of burning biofuels and the components of boiler heat balance and gaseous emission from the burning linden bark and briquettes. Particulate matter emission and content of soot were studied. The shape and composition of soot particles were determined with a Zeiss SIGMA VP electronic scanning microscope. Presented data were obtained using equipment of the Research Center of Power Engineering Innovations. The results of the comprehensive energy audit have shown that the Firematic 60 boiler provides high technical and economic performance with minimum emission of harmful substances to the atmosphere. It can be used for low-rise buildings heat supply in weather conditions of the Arctic region especially.
Forest fires and their environmental problems on the territory of Irkutsk Region
Authors: Belykh L I 
Published: January 2020

Abstract
The dynamics of forest fires in the Irkutsk region and its districts was studied. Over the past 30 years, there has been a tendency to increase the area of forest fires covered by fire. Areas with high forest burning were identified. Dynamics of the content of Benzo(a)pyrene in the atmosphere of cities and indicators of fires in the region and its districts are compared. It is established that the content of Benzo(a)pyrene in the air in many cities linearly depends on the area of forest fires. Dynamics of forest fires and the number of hunting fauna in the Irkutsk region districts were studied. With the help of linear correlations, the positive impact of fires on the population of the family of deer (Cervidae), canids (Canidae), cats (Felidae), bears (Ursidae) and pheasants (Phasianidae), due to one of such factors as the migration of animals from the burning nearby areas, was confirmed. Unstable and negative population dynamics was revealed for the populations of the Kunya family (Mustelidae).
Assessment of environmental damage from oil sludge to land resources in the Irkutsk Region
Authors: Gorlenko N V , Timofeeva S S 
Published: January 2020

Abstract
In Russia, the problem of sustainable development is most acute and representative. For the vast territories and rich natural subsoil resources, the environmental issue becomes the most acute. In Russia, from an environmental point of view, there are many territories of concern which make it clear that theoretical issues gain practical importance. The Central Siberian Plateau with its large reserves of raw hydrocarbons - the Lena-Tunguska oil and gas province with a total area of about 2.8 million km2 - is a region of intensive oil and gas production. The amount of ecosystem transformations has no analogues in Russia; all transformations were formed in a short period of time (30-50 years). To maintain this industry, linear and non-linear structures were built, which transformed the landscape and territories not only superficially: the exploration and well construction transformed the geology of the region. This article addressed the damage caused to the soils of the Irkutsk Region in oil and gas production by the three most promising fields: the Yarakta, Markovo and Dulisma fields. The calculation was made in accordance with the methodology for calculating the amount of damage caused to the soil as an object of environmental protection. The calculated damage without taking into account possible emergencies at oil and gas production facilities amounted to almost 100 million rubles.
Methods and techniques for controlling knowledge acquired at instructional briefings while occupational safety training
Authors: Sevastyanov B V , Lisina E B , Selyunina N V , Shadrin R O , Shalamova A V 
Published: January 2020

Abstract
The article is devoted to the analysis of control procedure organization as the final stage of labor protection educational process when studying the causes and prevention of injuries. In the course of the control procedures analysis,traditional and innovative methods of control has beenidentified and put into practice, considering the aspect of their effectiveness and efficiency. An examination of the methods of controlling knowledge mastering, as a result of safety briefings on avoiding industrial injuries, has been carried out. The potential of different methods of control has been revealed. It is assumed that the use of interactive methods and innovative forms of control increases the effectiveness of labor protection instructions, since besides the controlling function, they have the training potential.
Land reclamation technologies for direct dumping
Authors: Dudinskiy F V , Nechaev K B 
Published: January 2020

Abstract
The article describes features of the direct dumping method and analyzes various profiles of group dumps that meet land reclamation requirements. Main provisions oftechnological overburden and dumping schemes using draglines were analyzed. Three groups of technological schemes of overburden and dumping works were analyzed. They differ in methods of fillingof intermediate dumps when forming a group dump and land reclamation objectives. Technical and economic assessment of mining options using draglines for overburden and dumping works was carried out.Technical, economic and ecological results of mining operations were identified and analyzed.