bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body image, stress and coping strategies in adolescence
Authors: Soponaru Camelia 
Published: December 2020

The purpose of the study is to identify the level of stress among adolescents regarding body image and the strategies that they use to cope with it. 282 adolescents in 10th and 11th grade answered three questionnaires: the Adolescent Stress Questionnaire, the Body Image Coping Strategies Inventory and the Body Esteem Scale for Adolescents and Adults. In the order of results, factors generating stress in adolescents are money pressure, uncertain future, school/leisure conflicts, school performance, assuming adult responsibilities, school attendance, romantic relationships, home life, interactions with teachers and peer pressure. Girls are more stressed by home life, peer pressure, an uncertain future, money pressure and adult responsibilities, while boys by school attendance. The most frequently used coping mechanism is positive rational acceptance. The level of stress among adolescents correlates with the level of satisfaction regarding the body image.

Keywords: Body image, coping mechanisms, stress, adolescence, boys, girls.
Membangun Kesalingpercayaan dalam Proses Transfer Informasi antara Petani dan Penyuluh Pertanian
Authors: Prayoga Kadhung , Nurfadillah Suryani , Butar Ichma Butar , Saragih Manna 
Published: December 2020

<p>Information transfer process in agricultural extension requires strong trust between extension workers and farmers. Agricultural extension workers who are outsiders will deal with challenges in order to entering a farmers’ community familiar with the values and norms they adhere to. If there is no trust between farmers and extension workers, there will be no information exchange, nor any innovation adoption. This paper reviews low mutual trust between farmers and extension workers. To increase trust between farmers and extension workers, it is necessary to improve competence of communicators, to create conducive communication climate, to involve informal actors, and to carry out interpersonal communication. Extension workers must be able act as farmers and so do farmers. Mutual respect process and opportunities provision may improve trust between them. In the future, it is necessary to involve business sector, academics, and the media to improve the competence of extension agents for o improving their credibility.</p><p> </p><p>Abstrak</p><p>Proses transfer informasi dalam penyuluhan pertanian mensyaratkan adanya kepercayaan yang kuat antara penyuluh dan petani. Penyuluh pertanian yang notabene sebagai orang luar akan banyak mendapatkan tantangan ketika masuk ke dalam suatu masyarakat tani yang sudah terbiasa dengan nilai dan norma yang dianutnya. Tidak ada kepercayaan antara petani terhadap penyuluh menyebabkan tidak terjadi proses pertukaran informasi dan tidak akan terjadi proses adopsi inovasi. Tulisan ini merupakan review yang menggunakan data sekunder dari laporan maupun hasil studi untuk mengungkap rendahnya salingpercaya antara petani dan penyuluh. Untuk meningkatkan salingpercaya antara petani dan penyuluh adalah dengan cara meningkatkan kompetensi komunikator, menciptakan iklim komunikasi yang kondusif, melibatkan aktor-aktor informal, dan melakukan komunikasi interpersonal. Perlu adanya kondisi dimana penyuluh bisa memposisikan diri sebagai petani dan sebaliknya. Proses saling menghargai dan memberikan kesempatan inilah yang kemudian bisa memupuk lahirnya kepercayaan di antara keduanya. Ke depan perlu juga campur tangan sektor bisnis, akademisi, dan media untuk meningkatkan kompetensi penyuluh sehingga kredibilitas mereka juga bertambah.</p>
COST OF PRODUCTION AND FEASIBILLITY STUDY OF ORGANIC SITRONELA AGRIBUSINESS
Authors: Pribadi Ekwasita Rini , Kardinan Agus , Trisilawati Octavia , Rizal Molide 
Published: December 2020

<p>The cost production and business feasibility is useful in determining the price cost, and decision making for future business development of organic citonella. The research was conducted at the PT. Pemalang Agro Wangi in Jonggol - Bogor Regency in April 2019. Analysis of the cost of production was carried out by the full costing method. The feasibility test was carried out with several investment feasibility criteria, namely B/C ratio, NPV and IRR.Data collection was done by interviewing key informants, namely: producers and farmers of organic citronella using snowball sampling. The results showed that price cost of seeds, herbs and oil of organic sitronela were Rp.103,00/cuttings, Rp662,00/kg and Rp205.757,00/kg. The Organic sitronela nursery and herbs were feasible, at 7% / year interest rates, each produced Net B/C ratio were 4,7% and NPV Rp289.386.802,00 per ha, and B/C ratio of 1.05, NPV of Rp49.024.781,00 and IRR 17,92% for eleven ha Organic citronella cultivation produced essential oil content of 0.35% to 0.7% lower than inorganic cultivation &gt;1%, thus impact on higher cost of product. In order for the cultivation of organic citronella to develop, the selling price of oil should be more expensive than inorganic citronella oil.</p><p><strong>Keywords: </strong><em>Cymbopogon nardus</em><em> </em>(L.) Rendl, organic, cost price, business feasibility</p><p> </p><p><strong>Abstrak</strong></p><p><strong>ANALISA BIAYA POKOK DAN KELAYAKAN AGRIBISNIS SERAI WANGI ORGANIK</strong></p><p>Perhitungan harga pokok dan kelayakan usaha sangat bermanfaat dalam menetapkan harga jual, dan pengambilan keputusan untuk pengembangan usaha serai wangi organik. Penelitian dilakukan di kebun PT. Pemalang Agro Wangi di Jonggol – Kabupaten Bogor pada bulan April 2019. Analisis harga pokok produksi dilakukan dengan metode <em>full costing</em>. Uji kelayakan dilakukan dengan kriteria kelayakan investasi yaitu B/C ratio, NPV dan IRR. Pengumpulan data dilakukan dengan metode wawancara kepada informan kunci yaitu: produsen serai wangi organik dan petani penggarap menggunakan metode bola salju (<em>snowball sampling</em>). Hasil penelitian menunjukkan usaha agribisnis serai wangi organik menghasilkan harga pokok benih, daun dan minyak masing-masing sebesar Rp103,00/stek, Rp662,00/kg dan Rp205.757,00/kg. Usahatani benih dan daun serai wangi organik layak diusahakan, pada suku bunga 7%/tahun. Untuk usaha benih diperoleh B/C 4,7 dan NPV Rp289.386.802,00 per ha, serta untuk usaha daun diperoleh B/C 1,05, NPV Rp49.024.781,00 dan IRR 17,92 % per delapan ha. Budidaya serai wangi organik menghasilkan kadar minyak atsiri 0,35-0,7% lebih rendah dari pada budidaya anorganik (&gt;1%), sehingga berdampak pada harga pokok produk yang lebih tinggi. Agar budidaya serai wangi organik berkembang, harga jual minyak seharusnya lebih mahal dari minyak serai wangi anorganik.</p><p><strong>Kata kunci: </strong><em>Cymbopogon nardus </em>(L.) Rendl, organik, harga pokok, kelayakan usaha</p>
Uptake of Aβ by OATPs Might Be a New Pathophysiological Mechanism of Alzheimer Disease
Authors: Wen JinHua , Zhao MengHua , Zhou Ying , Lv YanNi 
Published: December 2020

Abstract
BackgroundThe accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic of Alzheimer's disease (AD). Over the last decade, a number of reports have shown that P-glycoprotein (encoded by ABCB1) actively mediates the efflux transport of Aβ peptides. However, the mechanism by which Aβ peptides enter the cells is not clear. We found that the protein expression oforganic anion transporting Polypeptide 2 (Oatp2) in the liver tissue of mice with AD was significantly higher than that in the normal mice. In contrast, the protein expression of Oatp2 in the brain significantly decreased in mice with AD. OATP1B1, an important drug transporter might be related to the pathophysiology of AD. ResultsIn this study, we established an OATP1B1-GFP-HEK293T cell model to confirm the OATP1B1 mediated transport ofAβ1-42.Compared to the c﻿ontrol group of GFP-HEK293Tcells, the uptake of Aβ1-42 protein in the OATP1B1-GFP-HEK293T group increased significantly with the increase in concentration of Aβ1-42, and also increased significantly with an increase in the duration of incubation. Similar results were observed in the flow cytometry experiment, and the uptake of Aβ1-42in HEK239T-OATP1B1 cells was almost twice that in the control group. These results indicate that OATP1B1 acts as an important “carrier” for the transport of Aβ1-42 from the blood to the tissues, including liver and brain. ConclusionsThis is a novel and interesting finding and OATP1B1 can be investigated as a new treatment target for AD.
Inhibition of DDR1 and DDR2 receptors: The Potential Therapeutic Option to Treat Pancreatic Fibrosis Demonstrated in Experimental Chronic Pancreatitis Model
Authors: Bansod Sapana , Saifi Mohd Aslam , Godugu Chandraiah 
Published: December 2020

Abstract
Discoidin domain receptors (DDR1 and DDR2) are the collagen receptors of the family tyrosine kinases, which play significant role in the diseases like inflammation, fibrosis and cancer. Chronic pancreatitis (CP) is a fibro-inflammatory disease in which recurrent pancreatic inflammation leads to pancreatic fibrosis.Methods: In the present study for the first time, we have investigated the role of DDR1 and DDR2 in cerulein-induced CP. Pancreatic DDR1 and DDR2 expression was examined by immunoblotting and immunostaining analysis. Subsequently, the protective effects of selective DDR1 and DDR2 inhibitor, imatinib (IMT) was investigated in CP mice as a therapeutic intervention.Results: Activated pancreatic stellate cells (PSCs) and CP mice showed significant upregulation of DDR1 and DDR2 expression. Pharmacological intervention with IMT effectively downregulated DDR1 and DDR2 expression. Further, we found that pancreatic injury, inflammation, extracellular matrix (ECM) deposition and PSCs activation were significantly inhibited by IMT. Further, we found a significant inhibition of TGF-β1/Smad signaling pathway by IMT and showed its protective effects against CP and associated fibrosis.Conclusions: Taken together, these results suggest that inhibition of DDR1 and DDR2 controls pancreatic inflammation and fibrosis, which could represent an attractive and promising therapeutic strategy for the treatment of CP.
Study to Assess the Utility of Discrete Event Simulation Software in Projection &amp; Optimization of Resources in Out-Patient Department at an Apex Cancer Institute in India: A Simulation Based Study
Authors: Singh Angel , Gupta Anant , Satpathy Sidhartha , Gowda Naveen 
Published: December 2020

Abstract
BackgroundHealthcare is growing more complex with mandate expanding from the primary function of providing care to include economic, legislative and social conditions that has led to the rise of numerous ancillary services. These have necessitated multiple new processes and systems which are closely intertwined. A study was done to create and run a discrete event simulation in OPD of a tertiary care cancer hospital of North India to project and optimize resource deployment.MethodsThe OPD process & workflow as per the expected load at tertiary care cancer hospital were finalized with various stakeholders in a focused group discussion. The finalized OPD process & workflow along with the OPD Building plans were utilized to develop a discrete event simulation model for the OPD at tertiary care cancer hospital using a DES. The simulation model thus developed was tested with incremental patient loads in 5 different scenarios/ “What if” situations (Scenario 1-5). The data regarding initial patient load and resources deployed was taken from on ground observations at tertiary care cancer hospital. ResultsIt was found that rooms and doctors were over-utilized and support staff utilization remained low. This was implemented with lesser waiting time for patients. No additional support staff was provided thus improving utilization of existing staff and saving on resources. The simulations enabled us to deploy resources just when it was required, which ensured optimal utilization and better efficiency. The peak census helped us to determine the capacity of the waiting area in different scenarios with incremental patient load and resource deployment.Conclusion﻿The Simulation software was very helpful, as “what if scenarios” could be created and the system tested, without disturbing the normal functioning of OPD. This enabled decision making before making on ground changes which saved lot of time and money.
Dietary Intakes and Plasma Polyunsaturated Fatty Acid Levels in Parkinson’s Disease
Authors: Yoo Dallah , Lim Yunsook , Son Yiseul , Rho Hyunkyung , Shin Chaewon , Ahn Tae-Beom 
Published: December 2020

Abstract
The study aims to determine the correlation between dietary intakes and plasma concentrations of PUFA and their associations with clinical severities in PD. We designed a case-control study to assess dietary fat intakes and disease severity in 38 PD patients and 33 healthy volunteers. Plasma levels of five PUFAs including α-linolenic acid (ALA), eicosapentaenoic acid, docosahexaenoic acid, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography. No differences were observed in dietary total energy and lipid intakes including PUFAs between two groups. PD patients had lower plasma levels of ALA, LA, and AA than controls. The associations between dietary intake and plasma concentrations of PUFAs were insignificant, whereas the association between dietary intake and plasma concentration of AA was exceptionally significant in controls. Plasma levels of ALA and LA were inversely associated with motor rating scores in PD patients, while that of AA was positively associated with non-motor symptoms.Plasma levels of ALA, LA, and AA were lower in PD patients than those in healthy controls, suggesting absorption problems in PD or expedited utilization of PUFAs. Contradictory relations on motor and non-motor symptoms imply conflicting clinical effects of PUFAs, raising questions about the usefulness of PUFA supplementation.
Molecular Characterization of Mitochondrial Genome From Trichostrongylus Species (Nematoda: Trichostrongylidae) in Northern Iran
Authors: Sharifdini Meysam , Hajialilo Elham 
Published: December 2020

Abstract
Background: The members of Trichostrongylus spp. are gastrointestinal nematodes of ruminants with worldwide distribution. The nematodes are considered as major health challenges especially in endemic regions of Iran. Several species of the parasite are reported from humans and animals in the country. Frequently, molecular analyses for identification of different species focus on nuclear regions and there is lack of information regarding the mitochondrial genes of Trichostrongylus spp. Therefore, the aim of the present study was to identify Trichostrongylus species by molecular analysis of mitochondrial gene in Guilan province, northern Iran.Methods: The nematodes were collected from the abomasum contents of sheep, goats and cattle. Morphological survey was performed for initial screening. Total DNA was extracted, and the partial region of cytochrome c oxidase subunit I (Cox1) gene was amplified and sequenced. Genetic diversity was calculated and phylogenetic analysis of the nucleotide sequence data was conducted.Results: Three species of Trichostrongylus including T. colubriformis, T. vitrines and T. axei were identified by morphological characterizations. The genetic divergence within the species in the present study was observed for T. axei (0-2.5%), T. colubriformis (0.77%) and T. vitrinus (0%). The mean inter-species difference between the Trichostrongylus species obtained in this study was 14.4- 15.4%.Conclusions: The Cox1 sequences of members of the Trichostrongylus spp. are highly variable and this could be used as a valuable measure for achieving a proper assessment of biodiversity. Sequence data generation from additional species of Trichostrongylus will be needed to reconstruct the phylogenetic relationships of this genus of nematodes.
Satisfaction of Surgical Informed Consent and Associated Factors Among Women Undergone Obstetric and Gynecologic Surgery at Jimma Medical Center, Jimma, Oromia Region, Ethiopia 2020.
Authors: Tesfa Tsegaw Biyazin , TAYE AYANOS , BELAY YESHITILA 
Published: December 2020

Abstract
Background: Informed consent is a process in which a healthcare provider obtains permission from an individual before delivering a certain health intervention. Patient satisfaction towards informed consent process is one main indicator of patient experience on health care services and mirror image of quality health care. The objective of this study was to assess the level of women satisfaction towards surgical informed consent and its associated factors at Jimma Medical Center, Ethiopia, 2020.Method: Facility based cross-sectional study was conducted from April 1 to May30, 2020 at Jimma Medical Center. A total of 372 surgical patients were selected using a systematic random sampling method. The collected data was coded, entered into Epi data version 3.1 and analyzed using SPSS version 25. Bivariate and multivariate regression was carrying out to determine the association between outcome variable and independent variable. Result: A total of 372 study participants were interviewed and giving a response rate of 97.8 %. Of this majority respondents were 167(44.9%) between 28-37 years old, married 310(83.3%), Urban residence 242 (65.1%) and housewife 168 (45%). Patients’ satisfaction towards surgical informed consent was 43%. Multivariate logistic regression analysis showed that residence (AOR: 2.279, 95% CI: 1.257-4.131), current referred history (AOR: 1.856, 95% CI: 1.033-3.337), language of the written consent form (AOR: 2.076, 95% CI: 1.143-3.773), time taken for informed consent provision (AOR: 5.227, 95% CI: 2.499-10.936) and patient to health provider relationship (AOR: 5.419, 95% CI: 3.103-9.464) were positively associated with patient satisfaction.Conclusion: In this study, the level of patient satisfaction towards surgical informed consent process was relatively low compared with previous studies. Health care professionals need to give emphasize on way of delivering informed consent, patients’ need and obey a standard informed consent process with evidence based practice to improve patient satisfaction.
Clinical Features of B. Cereus Sepsis in Premature Neonates
Authors: Li Na , Shen Yunlin , Gong Xiaohui , Hong Wenchao , Li Juan , Zhang Hongzhuan 
Published: December 2020

Abstract
Background: To analyze the clinical characteristics and prognosis of bacillus cereus sepsis in premature neonates.Method: Retrospectively analyze the data of 8 premature neonates of bacillus cereus sepsis in Shanghai Children’s Hospital from January 2015 to December 2019, where clinical information is collected from patients’ medical records and charts, information of neurodevelopment is collected for patients from follow-up visits at corrected age of 6 months and 12 months.Results: 8 premature neonates of bacillus cereus sepsis were identified, among which 5 cases developed meningitis, abnormal Cerebral MRI images were seen in 5 cases. After empirical antibiotic treatment with Meropenem and Vancomycin, 1 patient died, 7 patients survived to discharge. Follow-up visits discovered that 1 patient developed hydrocephalus and showed severely delayed neurodevelopment, 2 patients had mild neurodevelopmental delay, and neurodevelopment was basically normal in other 4 patients. Conclusions: Bacillus cereus infection can cause severe nervous system complications, and affect neurodevelopmental outcome. Empirical antibiotic treatment with Meropenem and Vancomycin is proven effective.
Bilateral Globus Pallidus Internus Deep Brain Stimulation for Parkinson’s Disease: Therapeutic Effects and Motor Outcomes Prediction
Authors: Shen Dingding , Cao Linhao , Ling Yun , Li Dianyou , Ren Kang , Yu Xiaoliu , Chen Zhonglue , Zhou Haiyan , Liu Jun 
Published: December 2020

Abstract
Background: Deep brain stimulation (DBS) has emerged as a highly effective surgical treatment for advanced Parkinson’s disease (PD). Good response in levodopa challenge test has suggested as criterion to identify optimal candidates for surgery. However, the response to levodopa and DBS is not always congruent, and predictive value of the levodopa test remains controversial. This study was set out to identify predictors of response to DBS and develop a novel prediction model evaluating DBS candidacy. Methods: Herein, we retrospectively analyzed 62 consecutive PD patients ﻿who underwent bilateral globus pallidus interna (GPi) DBS from 2016 to 2019. ﻿ The changes in UPDRS-III (Unified Parkinson’s Disease Rating Scale part III) total and subscores after surgery at one-year follow-up were evaluated and potential predictor variables were also collected. In the training cohort of 29 patients, we developed a novel machine learning method with 5-fold cross validations implementing on these variables to predict GPi DBS treatment outcomes in a multivariate linear analysis. ﻿Furthermore, the machine learning model was externally validated with another cohort of 33 GPi DBS PD patients.Results: GPi DBS significantly improved postoperative motor function of PD patients. The overall UPDRS-III scores improved by 30.4%, with highest improvement in tremor (75.0%), followed by limb bradykinesia (27.5%), rigidity (27.3%) and axial bradykinesia (22.4%). Most intriguingly, improvement in tremor can be predicted with high accuracy using this prediction model (adjusted R2= 0.82 for absolute improvement, and adjusted R2 = 0.76 for relative improvement), in which off medication tremor subscore was identified as the most powerful preoperative predictor. ﻿In the external validation cohort, the machine learning method showed good predictive performance.Conclusions: We confirmed the effects of bilateral GPi-DBS with a one-year follow-up. The good performance of the present prediction model demonstrated ﻿the utility of machine-learning based motor response prediction after GPi DBS, based on clinical preoperative variables.
The Largest Secure Corridor of the Infra-acetabular Screw—a 3-D Axial Perspective Analysis
Authors: Zhao Bei , Zhang Wei , Li Hao , Han Liren , Han Shizhang , Yang Xiaofei , Yan Jun , Mu Weidong 
Published: December 2020

Abstract
Background The infra-acetabular screw is placed from the pubis to the ischium and can be used as a special lag screw of the posterior column of the acetabulum. This study was performed to simulate the surgical procedure and try to obtain the ideal insertion point, diameter, length and angle of the screw through the method of axial perspective in Chinese patients.Methods We randomly collected the pelvic computed tomography (CT) scans of 200 adults. DICOM-formatted CT-scan images were imported into Mimics software. The 3D digital model of the right semi-pelvic was established. A virtual cylinder representing the screw was placed from the pubis to the ischium to fix the posterior column. The largest secure diameter and length of the virtual screw were measured. The position of the insertion point and the directions of the screw were also researched.Results The screw insertion safe zone can exhibit an irregular “tear drop” from the reconstructed pelvic model. The mean maximum diameter of screws was 5.01±1.28 mm, and the mean maximum length of screws was 93.99±8.92 mm. The screw insertion corridor with a diameter of at least 3.5mm was found in 94 of 100 males (94%) and 86 of 100 females (86%). We found gender-dependent differences for the mean maximum diameter and the maximum length of the screw. The position of insertion point was statistically significant in different genders.Conclusions The study provides a valuable guideline for the largest secure corridor of infra-acetabular screw. We suggest an individual preoperative 3D reconstruction simulation for the ideal screw placement. Further biomechanical studies are needed to verify the function of the screw.