bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projection of gut microbiome pre and post bariatric surgery to predict surgery outcome
Authors: louzoun yoram , Izhak Meirav Ben , Cohen Ruti , Shapiro Liora Madar , Meiri Hamutal , Wachtel Chaim , Eshel Adi , Leung Conrad , Messick Edward , Jongkam Narisra , Mavor Eli , Sapozhnikov Shimon , Maharshak Nitsan , Abu-Abeid Subhi , Alis Avishai , Mahler Ilanit , Meoded Aviel , Eldar Shai , Koren Omry 
Published: December 2019

Abstract
Background: Bariatric surgery is often the preferred method to resolve obesity and diabetes, with ~800,000 cases worldwide yearly and high outcome variability. The ability to predict the long-term BMI change following surgery has important implications on individuals and the health care system in general. Given the tight connection between eating habits, sugar consumption, BMI and the gut microbiome, we tested whether the microbiome before any treatment is associated with different treatment outcomes, as well as other intakes (HDL, Triglycerides, etc.).Results: A projection of the gut microbiome composition of obese (sampled before and after bariatric surgery) and slim patients into principal components was performed and the relation between this projection and surgery outcome was studied. The projection reveals 3 different microbiome profiles belonging to slim, obese and obese who underwent bariatric surgery, with post-surgery more different from the slim than the obese. The same projection allows for a prediction of BMI loss following bariatric surgery, using only the pre-surgery microbiome. A different projection is associated with sugar metabolism and A1C levels. Conclusions: - the gut microbiome can be naturally decomposed into main components depicting the patient's development and predicting in advance the outcome. Those may be translated into a better clinical management of obese individuals planning to undergo metabolic surgery.
Increasing soil pH enhances the network interactions among bacterial and archaeal microbiota in alpine grasslands of the Tibetan Plateau
Authors: Chen Beibei , Luo Shuaiwei , Ma Beibei , Qi Wei , Cao Changdong , Zhao Zhigang , Jiao Shuo , Du Guozhen , Ma Xiaojun 
Published: December 2019

Abstract
Background: Soil functioning and processes are driven by complex microbial interactions. It is therefore critical to understand the co-occurrence patterns of soil microbiota, especially in fragile alpine ecosystems. Here we explored the geographic patterns of the topological features and the major drivers shaping the topological structure of the co-occurrence network for bacterial and archaeal microbiota in alpine grasslands of the Tibetan Plateau based on high-throughput sequencing. Results: Soil pH was the most important environmental variable for predicting the topological features of the microbial network at both network and node levels. Associations among soil microbiota were enhanced with increasing pH (5.17–8.92), and the network was the most stable at neutral pH (7). Node-level topological features suggested that taxa of the high-pH cluster had more important roles in maintaining complex network connections than taxa of the low-pH cluster. Network-level features revealed closer relationships among soil microbiota in the steppe ecosystem than in the meadow ecosystem. Archaeal operational taxonomic units (OTUs) with higher values for node-level topological features appeared to be more important than bacterial OTUs in maintaining complex connections. The co-occurrence patterns of bacterial OTUs with lower node-level feature values followed a power-law distribution, whereas those of archaeal OTUs did not. Conclusions: Soil pH plays a decisive role in determining the complex interactions among soil microbiota in alpine grassland ecosystems of the Tibetan Plateau, with a more stable co-occurrence network at neutral pH. Bacterial and archaeal taxa, which occupy distinct network niches, have closer relationships in alpine steppe than in alpine meadow ecosystems.
A Comparison Study of Patients Satisfaction Rate of Registry System in Two Referral Hospitals Emergency Settings
Authors: Rezabakhsh Aysa , Delice Orhan , Vahdati Samad Shams , Arslan Senol , Hosseinifar Hossein , Ala Alireza , Houshmand Faride 
Published: December 2019

Abstract
BackgroundPatient satisfaction is an indirect indicator essential for evaluating the quality of care services and accurate predictor of health system policies. Recently, predictor factors affecting patient satisfaction are at the center of attention as well. The main objective of this study is to assess patient satisfaction rate during registry procedure in the emergency department of two referral hospitals.MethodsAn analytical cross-sectional study was conducted in both academic hospitals with high volume of patient admission in Tabriz-Iran and Erzurum-Turkey. We used a Press Ganey questionnaire as a data collection tool. Each patient or related companion filled out the self-administered questionnaire including 18 questions before discharging or referring to other area. Eventually, data were analyzed by using SPSS software version 16. Results Overall, 462 respondents were enrolled in this survey during three part-time courses including morning shift (122 patients), evening shift (112 patients) and night shift (228 patients). 48.92% of participants were male and 51.08% were female. Our results demonstrated that total satisfaction score in new (model) registry system was two scores higher than classic one (p<0.001). Furthermore, our findings showed a correlation between satisfaction rate and level of education and living place. In fact, patients with moderate education level in urban areas had higher satisfaction rate compared with rural regions (16±3.53 vs. 14.93±3.76; P=0.003) and higher/lower education levels (16.3±3.35 vs. 15.27±3.71 and 15.67±3.86; p=0.03). Conclusion Take together attempts at improving patient flow as well as satisfaction rate in emergency department could reduce hospital costs and improve the quality of health care.
Essential Newborn Care Utilization and Associated Factors in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Alamneh Yoseph Merkeb , Nigat Fentahun Adane , Yirga Tadesse Yirga , Desta Melaku Desta 
Published: December 2019

Abstract
Background: Globally, neonatal death accounted for 46% of under-five deaths and more than 80% of newborn deaths are the result of preventable and treatable conditions. In Ethiopia, contradict and inconsistent studies have been conducted to assess the prevalence of essential newborn care utilization and associated factors. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of essential newborn care utilization and associated factors in Ethiopia. Methods: The international databases include MEDLINE/PubMed, EMBASE, Web of Sciences, Scopus, and Grey literature databases, Google Scholar, Science Direct and Cochrane library were scientifically explored. All primary studies reporting the prevalence of essential neonatal care utilization and associated factors in Ethiopia were considered. All necessary data were retrieved by using a standardized data extraction format, spreadsheet. STATA 14 statistical software was used to analyze the data and Cochrane Q test statistics and I2 test was used to assess the heterogeneity between the studies. There was significant heterogeneity between the studies so that a random effect model was computed. Results: The pooled estimate for utilization essential newborn care utilization from 11 studies in Ethiopia was 48.768% (95% CI: 27.891, 69.645). Residence [ OR = 2.50 (95% CI: 1.64, 3.88)], Postnatal care [OR=5.53, 95% CI = (3.02, 10.13], counseling during pregnancy and delivery [OR=4.39, 95% CI = (2.99, 6.45], antenatal care follows up (OR=6.84; 95% CI: 1.15, 4.70) and maternal educational status [OR = 1.63 (95% CI: 1.12, 2.37)] were identified as the associated factors of essential newborn care utilization. Conclusion: Based on the current study essential newborn care utilization in Ethiopia was significantly low as compared to the current global recommendation on essential neonatal care utilization. Place of residence, Postnatal care, counseling during pregnancy and delivery, antenatal care follows up and maternal educational status were associated risk factors variables. Hence, appropriate newborn services utilization at health facilities and raising mother’s level of awareness about newborn care practices should be recommended.
Effectiveness of pharmacotherapy for smoking cessation: Umbrella review and quality assessment of systematic reviews
Authors: Melka Alemu Sufa , Chojenta Catherine L , Holliday Elizabeth G , Bali Ayele G , Loxton Deborah J 
Published: December 2019

Abstract
Background: In the long term, smoking cessation can decrease the risk of cancer, stroke, and heart attacks and improve overall survival. This umbrella review aimed to assess the effect of pharmacological interventions on smoking cessation and to evaluate the methodological quality of previously conducted systematic reviews. Methods: Databases including the Cochrane library, PubMed, MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, Scopus and Google Scholar were used to retrieve reviews. Systematic reviews that included only randomized controlled trials designed to assess pharmacotherapeutic interventions supporting abstinence from smoking were considered in this umbrella review. Each review was assessed for quality using the Revised Assessment of Multiple Systematic Reviews (R-AMSTAR) tool. Two authors (AM, AB) screened the titles and abstracts of all reviews obtained by the search strategy, assessed the full text of selected articles for inclusion and extracted data independently. Two authors (AM, AB) also performed a quality appraisal independently and Cohen’s Kappa statistic was used to assess inter-rater agreement. The findings of the studies were narrated qualitatively to describe the evidence regarding the effectiveness of pharmacotherapies for smoking cessation.Results: Nine reviews were included in this umbrella review. Most of the reviews included in this review reported that Nicotine Replacement Therapy (NRT), bupropion and varenicline were effective for smoking cessation. The combination of a nicotine patch with other nicotine formulations was also more effective than monotherapy. Similarly, the combination of nicotine with the non-nicotine therapy varenicline was found to be more effective than varenicline alone. However, the opioid antagonist naltrexone alone was not found to be effective for smoking cessation nor in combination with nicotine replacement therapy. The quality of reviews published after the development of the R-AMSTAR tool was higher than reviews published before the inception of the tool.Conclusions: This review revealed that drugs approved by the US Food and Drug Administration (FDA) are effective for smoking cessation. A combination of nicotine patches with other nicotine formulations was also effective for smoking cessation compared to nicotine monotherapy. The quality of papers published after the development of the AMSTAR tool demonstrated better quality compared to papers published before the inception of the tool.
Intracranial aneurysms associated with middle cerebral artery anomalies: the clinical characteristics and treatment considerations: a systematic review
Authors: Hou Kun , Li Guichen , Liu Hongping , Xu Kan , Yu Jinlu 
Published: December 2019

Abstract
Background: As a result of its low occurrence, most of the studies on intracranial aneurysms associated with MCA anomalies were presented as case reports or small case series. In this study, a systematic review on this specific entity was conducted. Methods: A PubMed search of the published studies was performed on April 6th, 2019 for patients who had intracranial aneurysms associated with MCA anomalies. The languages included in this study were English, Chinese, and Japanese. Results: Finally, 58 articles reporting of 67 patients including 1 case in our center were included. The identified patients (37 females, 55.2%) aged from 4 to 81 (49.85 ± 15.22) years old. Fifty (50/67, 74.6%) patients presented with hemorrhagic stroke either because of rupture of the aneurysms associated with MCA anomalies or other sources. Sixty-three aneurysms (63/67, 94.0%) were saccular, 3 (4.5%) were dissecting or fusiform, and 1 (1.5%) was pseudoaneurysm. Thirty-two (32/65, 49.2%) patients had other concurrent cerebrovascular anomalies. Fifty-six (83.6%) patients underwent open surgeries, 8 (11.9%) patients underwent endovascular treatment, and 3 (4.5%) patients were conservatively managed. Fifty-six (56/61, 91.8%) patients achieved a good recovery. Conclusions: The pathophysiological genesis of MCA anomalies associated aneurysms is still obscure to us. The inflicted patients tend to have concurrent other cerebrovascular anomalies, which denotes that congenital defect in cerebrovascular development might play a role in this process. Open surgery is, hitherto, the mainstay of treatment for this specific entity. Most of the affected patients could experience a good recovery.
Diagnostic Performance of CTA and vessel wall MR imaging in Carotid webs—A Retrospective Study
Authors: Zheng Hanpei , Li Huan , Li Sirui , Wu Xiangbo , Bin Mei , Wang Yinghui , Xu Haibo 
Published: December 2019

Abstract
Background: There currently is no consensus on the performance of Vessel wall MRI (VW MRI) with carotid webs (CaWs). No clear data exist on compare the performance of each diagnostic features in CaWs. Purpose: To set a standards about the diagnostic features and compare the performance of each diagnostic features in CaWs. Materials and methods : All patients (n = 165, median age, 56.9 ± 13.3) who has done both neck CTA and VW MRI in our radiology department, Zhongnan hospital, performed from February 2017 to April 2019 were included. All CTA and VW MRI images were read by two experienced radiologists. Interobserver agreement for the two reader’s decision of CTA was checked by using kappa statistics. Sensitivity, specificity, and area under the curve (AUC) of each diagnostic features at CTA and VW MRI were compared. Results: 10 patients with carotid web was found. The feature “double lumen sign” of CTA and “valve sign” and “contrast stasis” of VW MRI showed good specificity (specificity, 98.6% vs 92.9% vs 93.6%, respectively; P<0.001). The feature “double lumen sign” of VW MRI compared to it of CTA showed higher sensitivity (sensitivity, 80.0% [8 of 10] vs 50.0% [5 of 10], respectively; P<0.001) and better diagnostic performances (area under the curve [AUC], 0.93 [95% CI: 0.68, 0.97] and 0.74 [95% CI: 0.54, 0.94], respectively; P<0.001). Conclusion: The feature “double lumen sign” and “a line or septum” of CTA and “valve sign” and “contrast stasis” of VW MRI may be a crucial performance of carotid web.
Detection and prevalence of Cercopithifilaria bainae infection in shelter dogs in Oklahoma, USA
Authors: Lineberry Megan W. , Sundstrom Kellee D. , Little Susan E. , Stayton Erin M. , Allen Kelly E. 
Published: December 2019

Abstract
Background Cercopithifilaria bainae is a filarioid nematode of dogs. Infection with the parasite was not reported in the USA until 2017, when a dog with skin lesions in Florida was diagnosed. Brown dog ticks, Rhipicephalus sanguineus sensu lato, are the purported tick vectors, and are widespread in the USA. Therefore, C. bainae is likely present in additional states. Here, we tested dogs and ticks in Oklahoma for evidence of C. bainae infection.Methods Dermal punch biopsies were opportunistically collected from municipal shelter and client-owned dogs. Multiple skin samples collected from interscapular and head regions were tested by saline sedimentation to recover live microfilariae for morphometric identification and by PCR to amplify a 330 bp region of 12S filarioid rDNA. Also, ticks observed on surveyed dogs were collected, identified to species level, and tested for filarioid DNA.Results A total of 1,521 biopsy samples were collected from 230 shelter and 20 client-owned dogs. Cercopithifilaria bainae infections were identified in 2.6% (6/230) of shelter dogs by morphometry of microfilariae in sedimentations and/or amplification of DNA from skin. DNA sequences amplified from PCR positive skin samples were 99–100% identical to C. bainae reported in Italy. All skin samples from client-owned dogs were negative for filarioid infection by saline sedimentation and PCR. A total of 112 ticks, comprised of four species, were collected. Two of 72 R. sanguineus s.l., both replete females found attached to a C. bainae infected dog, harbored C. bainae DNA (99–100% identity). One attached R. sanguineus s.l. male on the same dog harbored filarioid DNA sequence which was difficult to interpret at numerous base-pair locations, but was closest in identity (~80%) to C. bainae.Conclusions The distribution of C. bainae is more widespread than previously known. Here, we document C. bainae infections in dogs and DNA in brown dog ticks in Oklahoma for the first time. As brown dog ticks are commonly found throughout the USA, veterinarians in this region should consider C. bainae infection as a differential diagnosis in canine patients with dermatitis or polyarthritis.
Resistance against macrocyclic lactones in Psoroptes ovis in cattle
Authors: Mol Wouter van , De Wilde Nathalie , Casaert Stijn , Chen Zhenzhen , Vanhecke Marieke , Duchateau Luc , Claerebout Edwin 
Published: December 2019

Abstract
Background Psoroptic mange is an important disease in beef cattle, and Belgian Blue cattle are particularly susceptible. Treatment failure of macrocyclic lactones against Psoroptes ovis has been reported, but clear evidence of in vivo resistance is still lacking. This study was conducted to investigate ML efficacy in 16 beef farms in Belgium and The Netherlands in vivo and in vitro.Methods On each farm a group of animals (n= 7-14) with clinical psoroptic mange was treated with two subcutaneous injections of a macrocyclic lactone with 7-10 days interval (15 farms) or a single injection with a long-acting macrocyclic lactone (1 farm). In vivo efficacy was assessed by the reduction in mite counts and clinical index (part of the body affected by lesions), the cure rate after the first treatment round and the number of treatment rounds needed to cure all animals. In vitro knock-down and mortality was evaluated in a contact test.Results Cure rates after the first treatment round varied from 0-80%. All farms needed two or more rounds of treatments to obtain full efficacy. Clinical index had a high variation and only started to reduce after the second treatment round. Only three farms were categorized as susceptible with a mean mite count reduction>95% and a lower limit of the uncertainty interval>90%. One farm had a mean reduction>95%, but its lower limit of the confidence interval was <90%. All other farms had mean reductions<95% and lower limits of their uncertainty intervals<90%. No correlation was found between in vitro lethal dose 50 and knock-down dose 50 values and any parameter of in vivo efficacy.Conclusion Unambiguous treatment failure was detected on 12/16 beef farms, confirming the presence of macrocyclic lactone resistance in Belgian Blue beef farms. In vitro parameters could not discriminate the farms based on their in vivo susceptibility. The mean reduction in mite counts and the lower limit of the confidence interval stood out as most useful parameter to identify acaricide resistance.
Commuting time and Sickness Absence: Evidence from China
Authors: Wang Zicheng , Liu Jiachun , Guo Murong 
Published: December 2019

Abstract
Background: Most of employees in urban China have experienced a heavy commuting burden ，which has become an urgent issue that should be solved in the process of promoting the new urbanization strategy. However, not only has the exploration of relationship between commuting and sickness absence been still scant in China, but also there is no discussion made to analyze the mechanism linking the commuting time and sickness absence. To address these gaps, this study firstly investigates the commuting-absence effect as well as the potential transmission channel between them. Methods: Using a unique dataset of 2013 Matched Employer-Employee Survey (CMEES) in China, we apply the zero-inflated negative binomial model to explore the nexus between the commuting and sickness absence. To discuss the potential mechanism linking commuting and sickness absence in the context of China, the estimations of the impact of the commuting on health-related outcomes and work efforts are performed to confirm transmission channels of commute-absence effect by the OLS and Logit regression model. Results: The empirical results reveal that a longer commute has a positive effect on sickness absences, while it is still robust against several specifications. More importantly, the commuting-absence effect is mainly transmitted through health-related outcomes of employees, whereas we cannot find evidence that the effect is transmitted through shirking behavior s. Additionally, the heterogeneous effects of commuting-absence are differentiated across Hukou status, gender, pattern of commuter travel, scale of cities and types of enterprises . Conclusion: The long commute induces to lower productivities through the sickness absence, that is, the longer journey from home to work is positively related with the increasing sickness absence, which keeps in consistency with previous studies. And the potential effect of commute-sickness absence is mainly transmitted through their health-related outcomes.
Prevalence and risk factors of acute lower respiratory infection among children living in biomass fuel using households: A community-based cross-sectional study in Northwest Ethiopia
Authors: Adane Mesafint Molla , Alene Getu Degu , Mereta Seid Tiku , Wanyonyi Kristina L. 
Published: December 2019

Abstract
Background: Childhood acute lower respiratory infection in the form of pneumonia is recognized as the single largest cause of childhood death globally accounting for 16% of the overall deaths. Some studies also reported a higher prevalence of childhood acute respiratory infection in Ethiopia, which ranges from 16% up to 33.5%. Concerning the risk factors, there are limited community-based studies in Ethiopia in general, and in the current study region in particular. Therefore, the present study was conducted to investigate the prevalence of childhood acute respiratory infection and associated factors in Northwest Ethiopia. Methods: As part of the wider stove trial project, a cross-sectional study was conducted in May 2018 among a total of 5830 children aged less than four years old in randomly selected clusters. Binary logistic regression was applied to identify factors linked with childhood acute lower respiratory infection and adjusted odds ratios were used as measures of effect with a 95% confidence interval. Results: A total of 5830 children were included in the study within 100 clusters. Out of which 51.7% were male and 48.3% female. The prevalence of childhood lower acute respiratory infection was 19.2% (95% CI: 18.2-20.2) and found to decrease among children living in homes with chimney, eaves space and improved cookstove than children living in households with no chimney, eaves space and improved cookstove with estimated AOR of 0.60 (95% CI: 0.51-0.70), 0.70 (95% CI: 0.60-0.84) and 0.43 (95% CI: 0.28- 0.67) respectively. It was also associated with other cooking-related factors such as cow dung fuel use [AOR=1.54 (95% CI: 1.02-2.33)], child spending time near stove during cooking [AOR=1.41 (95% CI: 1.06-1.88), presence of extra indoor burning events [AOR= 2.19 (95% CI: 1.41-3.40)] and with frequent cooking of meals [AOR=1.55 (95% CI: 1.13- 2.13)]. Conclusion: High prevalence of childhood acute lower respiratory infection was demonstrated by this study and it was found to be associated with household ventilation, cooking technology, and behavioral factors. Therefore, we recommend a transition in household ventilation, cooking technologies as well as in child handling and in the peculiar local extra indoor burning practices.