bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trisomy 21 and Ebstein Anomaly: Diagnosis and Prognosis of a Rare Association
Authors: Brandão Gabriela Rangel , Welter Amanda Thum , Abech Gabriel Dotta , Almeida Carla Bastos da Costa , Okabayashi Caio Seiti Mestre , Gadelha Kerolainy Alves , Zen Paulo Ricardo Gazzola , Rosa Rafael Fabiano Machado 
Published: July 2020

AbstractTrisomy 21 is considered the most common chromosomal aneuploidy, and congenital heart disease (CHD) is highly prevalent and relevant to the morbidity and mortality of these patients. Ebstein anomaly (EA) is a rare CHD characterized by tricuspid valve dysplasia with inferior septal leaflet displacement. Herein, we described a patient with trisomy 21 who presented with EA and discuss the association between the two conditions based on a literature review. We conclude that the concomitant occurrence of both conditions is considered to be rare. These individuals are most frequently diagnosed during birth and childhood, and they usually have a good prognosis, as observed with our patient and is typical for EA patients in general. However, it is important to be aware that electrophysiologic anomalies may also be present.
The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase
Authors: Ishibashi Yohei , Ito Makoto , Hirabayashi Yoshio 
Published: July 2020

Abstract
The accumulation of glucosylceramide (GlcCer), which is synthesized by UDP-glucose ceramide glucosyltransferase (UGCG), is associated with several diseases, including Gaucher disease and Parkinson’s disease. Since the inhibition of UGCG can be used to treat diseases caused by GlcCer accumulation, several UGCG inhibitors have been developed. In this study, we report on the inhibition of UGCG activity by cambinol, a sirtuin inhibitor. Unlike conventional UGCG inhibitors, cambinol has no structural similarity to GlcCer. LC-ESI MS/MS analysis revealed that the cellular GlcCer levels were reduced by cambinol with an increase in ceramide, the GlcCer precursor. Histidine 193 plays an important role in the inhibition of UGCG via a known UGCG inhibitor, D-PDMP. However, cambinol was found to inhibit UGCG activity in a histidine 193-independent manner. This study provides insights into the mechanism of inhibition of UGCG activity by cambinol, and provides a basis for the development of a cambinol-based novel UGCG inhibitor.
DNA damage in mononuclear cells following maximal exercise in sedentary and physically active lean and obese men
Authors: Peres Alessandra , Da Silva Igor M. , Santos Maeli , Beretta Ângela , Andrade Vanessa Moraes , RomãO Pedro R. T. , Dorneles Gilson P. 
Published: July 2020

We evaluated the impact of maximal exercise on oxidative stress and DNA damage in peripheral blood mononuclear cells (PBMC) from sedentary and exercised lean and obese men. PBMC were collected before, immediately and 1‐h after exercise and exposed to hydrogen peroxide (H2O2; 25 and 50 µM, 4 h). A leukocytosis was induced by maximal exercise immediately and 1‐h after exercise in all groups. However, a lymphopenia was observed 1‐h after exercise in the Sedentary obese group. In the control condition, low DNA damage index concomitant to increases in intracellular glutathione content (GSH) was identified immediately after exercise in all groups. However, higher DNA damage index and lipid peroxidation occurred 1‐h after the bout in Sedentary and Exercised Obese groups. PBMC exposed to both H2O2 25 and 50 µM experienced higher DNA damage and lipid peroxidation index immediately after exercise in all groups. Both lipid peroxidation and DNA damage index remained higher in PBMC of Sedentary Lean, Sedentary Obese, and Exercised obese groups obtained 1‐h after exercise in both H2O2 25 and 50 µM, with the highest values identified in PBMC from Sedentary Obese group. However, increases in GSH content were identified in treated PBMC from sedentary and exercised lean groups as well as exercised obese group 1‐h after exercise. Habitual exercise confers increased resistance of PBMC to DNA damage induced by oxidative stress, reducing the detrimental effects of obesity.Keywords: Exercise, physical activity, DNA damage, obesity, mutagenesis, oxidative stress
Wearable resistance sprint running is superior to training with no load for retaining performance in pre‐season training for rugby athletes
Authors: Feser Erin H. , Bayne Helen , Loubser Ignatius , Bezodis Neil E. , Cronin John B. 
Published: July 2020

AbstractThis study determined the effects of a six‐week lower‐limb wearable resistance training (WRT) intervention on sprint running time, velocity, and horizontal force‐velocity mechanical variables. Twenty‐two collegiate/semi‐professional rugby athletes completed pre‐ and post‐intervention testing of three maximal effort 30 m sprints. A radar device was used to measure sprint running velocity from which horizontal force‐velocity mechanical profiling variables were calculated. All athletes completed two dedicated sprint training sessions a week for six‐weeks during pre‐season. The intervention (wearable resistance, WR) group completed the sessions with 1% body mass load attached to the left and right shanks (i.e. 0.50% body mass load on each limb), whilst the control group completed the same sessions unloaded. For the control group, all variables were found to detrain significantly (p ≤ 0.05) over the training period with large detraining effects (ES > 0.80) for theoretical maximal horizontal force, slope of the force‐velocity profile, maximal ratio of force, index of force application, 5 and 10 m times. For the WR group, there were no significant changes to any recorded variables (all p > 0.05) and all effects of training were trivial or small (ES < 0.50). After adjustment for baseline differences, significant between group differences were found for all variables (large effects, ES > 0.80) except theoretical maximal velocity, 30 m time, and maximal velocity. The addition of light wearable resistance to sprint training during a six‐week pre‐season block enables the maintenance of sprint performance and mechanical output qualities that otherwise would detrain due to inadequate training frequencies.
Self-gravitating razor-thin discs around black holes via multi-hole seeds
Authors: Vieira Ronaldo S S 
Published: July 2020

Abstract
We construct self-gravitating razor-thin discs of counterrotating matter around Schwarzschild black holes (BHs) by applying the ‘displace, cut, and reflect’ method to known seed solutions representing multi-holes. All but one of the sources of the seed solution generate the surrounding annular disc, whereas the remaining BH is mapped onto a Schwarzschild BH which lies at the disc centre after the transformation. The discs are infinite in extent, have annular character, and are linearly stable up to the innermost stable circular orbit (ISCO) of the system. The spacetime is asymptotically flat, having finite Arnowitt–Deser–Misner mass. Moreover, all energy conditions for the disc are satisfied for radii larger than the ISCO radius; the method, however, produces counterrotating streams with superluminal velocities in the vicinity of the central BH. We also comment on charged discs around extremal Reissner–Nordström BHs constructed from a Majumdar–Papapetrou N-BH seed solution. These simple examples can be extended to more general ‘BH + disc’ solutions, obtained by the same method from seeds of the type ‘BH + arbitrary axisymmetric source’. A natural follow-up of this work would be to construct discs around Reissner–Nordström BHs with arbitrary charge-to-mass ratio and around Kerr BHs.
Development and validation of experimental modal analysis with fixture-free oblique impact testing based on a vector projection method
Authors: Yee Khoo Shin , Cheng Lian Yee , Chao Ong Zhi , Ismail Zubaidah , Noroozi Siamak 
Published: July 2020

Abstract
Experimental modal analysis (EMA) with oblique excitation (i.e. oblique impact testing) is useful in improving the long test time problem of conventional EMA with normal excitation (i.e. triaxial normal impact testing), in order to extract all the important dynamic characteristics of a 3D complex structure. In this study, a new methodology involving a vector projection method is introduced to find the driving point frequency response function (FRF) in the oblique direction, without the need for a special fixture with an obliquely oriented impedance head. Hence, this presents a low cost and practical solution for scaling the mode shape, as compared to the traditional approach. Moreover, the concurrent forces characteristic of oblique excitation are used in the development of the theoretical relationship between FRFs with oblique excitation and those with normal excitation. This is important for the validation of the oblique impact testing result, such as the FRF and modal parameter estimations. The experimental results show that oblique impact testing has reliable and effective results, as compared with the triaxial normal impact testing, in terms of the FRF correlation, natural frequency discrepancy, modal damping ratio error and modal assurance criterion of the unit modal mass mode shape.
3D numerical analysis of mass diffusion in (nano) composites: the effect of the filler-matrix interphase on barrier properties
Authors: Zid Sarra , Zinet Matthieu , Espuche Eliane 
Published: July 2020

Abstract
Polymer nanocomposites based on impermeable fillers have been widely developed to improve gas barrier properties. These materials have to be viewed as three phase systems: the matrix, the fillers and an interphase layer between the filler and the matrix. In this paper, the effect of the interphase layer on the overall diffusivity of nanocomposites loaded with impermeable disk-like fillers is analyzed and quantified through 3D finite element modeling of mass diffusion. Ideal ordered filler distributions as well as random filler distributions are considered for filler content in the range 1–20 vol%. A parametric study covering interphase thickness to filler thickness ratio values between 0.125 and 0.5 and interphase diffusivity ratio D
interphase/D
matrix values from 10−4 to 106 is presented and discussed. The results show that, depending on their quality (weakly or highly diffusive), the presence of interphases can be either beneficial or totally detrimental to the nanocomposite overall barrier properties. A specific case corresponding to the exact compensation of the tortuosity effect by the diffusion in the interphase layer is evidenced and analyzed. Moreover, the effect of continuous diffusion paths, which may occur between overlapping interphases, is investigated. This effect appears to be particularly critical for the barrier performance in the case of highly diffusive interphases. Finally, a confrontation between our simulation approach and an analytical model as well experimental data is proposed.
Reply to comment on ‘Improvements for drift-diffusion plasma fluid models with explicit time integration’
Authors: Teunissen Jannis 
Published: July 2020

Abstract
This is a reply to the comment of Jiayong Zou on the paper ‘Improvements for drift-diffusion plasma fluid models with explicit time integration’. The criticism in the comment, namely that the current-limited approach is inconsistent with the underlying partial different equations, seems to be invalid. However, this criticism raises an interesting question about the behavior of the current-limited scheme for a given time step, which is discussed in this reply.
Multi-hollow surface dielectric barrier discharge: an ozone generator with flexible performance and supreme efficiency
Authors: Homola Tomáš , Prukner Václav , Hoffer Petr , Šimek Milan 
Published: July 2020

AbstractThis contribution investigates the effects of duty cycle and mass flow of synthetic air and oxygen on the efficiency of ozone generation in multi-hollow surface dielectric barrier discharge (MSDBD). It discloses that the efficiency of ozone generation in MSDBD is significantly higher compared with standard coplanar DBD, surface DBD and volume DBDs. Ozone production yield reached 205.5 ± 29.1 g (kW h)−1(40% duty cycle, 8 slm) and 413.91 ± 58.7 g (kW h)−1(100% duty cycle, 8 slm) at an energy cost of 8.7 and 4.3 eV/molecule for synthetic air and oxygen, respectively. Such high ozone yields arose out of the intrinsic characteristics of MSDBD ceramics, which were efficiently cooled by the flow of the working gas. The amplitude modulation of low-frequency 5 kHz high-voltage sine waveforms facilitates controlled O3production at a nearly constant rate of yield. Since the correct evaluation of ozone production yield requires precise determination of the discharge power, the concentration of ozone and working gas-flow, considerable attention was paid to measurements of these parameters. It is confirmed and experimentally demonstrated herein that correct determination of discharge power lies with Lissajous figure methods, while the determination of power through the direct integration of productu(t)i(t), wherei(t) is measured by Pearson current probe, leads to systematically lower values of calculated power with consequent overestimation of the ozone production yield. The correct determination of discharge power is clearly the key to the proper calculation of ozone production yield and efficiency. Under the DBD discharge conditions presented herein, ozone production yield and efficiency achieved figures as high as 19.5% and 35.2% of theoretical limits recently established for air and oxygen, respectively.
Bose–Einstein condensation of nonequilibrium magnons in confined systems
Authors: Mohseni Morteza , Qaiumzadeh Alireza , Serga Alexander A , Brataas Arne , Hillebrands Burkard , Pirro Philipp 
Published: July 2020

Abstract
We study the formation of a room temperature magnon Bose–Einstein condensate (BEC) in nanoscopic systems and demonstrate that its lifetime is influenced by the spatial confinement. We predict how dipolar interactions and nonlinear magnon scattering assist in the generation of a metastable magnon BEC in energy-quantized nanoscopic devices. We verify our prediction by a full numerical simulation of the Landau–Lisfhitz–Gilbert equation and demonstrate the generation of magnon BEC in confined insulating magnets of yttrium iron garnet. We directly map out the nonlinear magnon scattering processes behind this phase transition to show how fast quantized thermalization channels allow the BEC formation in confined structures. Based on our results, we discuss a new mechanism to manipulate the BEC lifetime in nanoscaled systems. Our study greatly extends the freedom to study dynamics of magnon BEC in realisitc systems and to design integrated circuits for BEC-based applications at room temperature.
Feature Selection in Cross-Project Software Defect Prediction
Authors: Saifudin A , Trisetyarso A , Suparta W , Kang C H , Abbas B S , Heryadi Y 
Published: July 2020

Abstract
Advances in technology have increased the use and complexity of software. The complexity of the software can increase the possibility of defects. Defective software can cause high losses. Fixing defective software requires a high cost because it can spend up 50% of the project schedule. Most software developers don’t document their work properly so that making it difficult to analyse software development history data. Software metrics which use in cross-project software defects prediction have many features. Software metrics usually consist of various measurement techniques, so there are possibilities for their features to be similar. It is possible that these features are similar or irrelevant so that they can cause a decrease in the performance of classifiers. In this study, several feature selection techniques were proposed to select the relevant features. The classification algorithm used is Naive Bayes. Based on the analysis using ANOVA, the SBS and SBFS models can significantly improve the performance of the Naïve Bayes model.
Extended Generic Process Model For Analysis MITM Attack Based On Evil Twin
Authors: Ahmad MS , Lutfi S , Abdullah SD 
Published: July 2020

Abstract
The high of criminal level related to the field of networking, is a threat that is quite dangerous MITM. The perpetrators of this attack use a fake AP (access point) with different gateway settings that are legitimate AP, so this type of attack becomes quite difficult to detect. This is due to the lack of standard operating procedures (SOP) in handling this case. This research was conducted with the aim of making a forensic model based on the analysis stages in the Evil Twin based MITM case using the user side based live forensic method. The results of the forensic investigation in the study resulted in an investigative model of ENFGP (Extended NFGP) which was divided into 10 stages and consisted of 30 completion steps, obtained through the process of testing and implementation methods in the MITM based Evil Twin attack and further testing based on several previous forensic models
Using Self-Organizing Map (SOM) for Clustering and Visualization of New Students based on Grades
Authors: Purbasari I Y , Puspaningrum E Y , Putra A B S 
Published: July 2020

Abstract
Student grouping, particularly in high school, is a necessary process to divide and classify students into classes based on their abilities and interests. Each school may have different approaches to decide the grouping, but most schools use academic grades. The activity occurs every new academic year and schools with plenty of new students registered may feel a bit overwhelmed with this grouping assignment. A decision support system which can automatically perform grouping on a list of students may be able to help the school’s staffs with this repetitive task. A self-organizing map (SOM) is an example of unsupervised learning algorithm using an artificial neural network structure to produce a low dimensional representation from a given input. However, SOM is also known as one of clustering techniques, since dimensionality reduction may also be seen as reducing (or clustering) input data to lower dimensions (or clusters). This research aims to group new enrolled students to a high school based on their academic grades using a SOM learning algorithm. The grades came from their rapport books and national examination results from their previous study. The resulting groups are three distinct clusters which represents Life Sciences, Social Sciences, and Linguistics study areas.
How IT Support a Government Organization’s Agility to Respond Citizen’s Changing Needs?:Literature Review
Authors: Safitri Eristya Maya , Susanto Tony Dwi , Hadiwiyanti Rizka , Pratama Arista 
Published: July 2020

Abstract
Now the use of information technology has changed citizen’s styles and lifestyle. Public services that are practical, very fast and automated is the need for majority of Indonesian society. Coupled with various requests for public services needed by the community with a variety of specific case studies. This certainly has implications for the government in presenting services that suitable with the various needs of the citizen. On the other hand, in increasing the effectiveness and efficiency of public services, the government has shifted its business processes by increasing the adoption of e-government. However, the fact is the IT investments that can reach tens or hundreds millions rupiah every year can be said to be almost non-existent by governments where most of the operational processes are carried out electronically. To overcome this problem, the government should not simply shift the business process with IT adoption on a large scale. The government needs to adopt a model of organizational agility to support government IT agility. In anticipating this, several previous studies have contributed to developing an organizational agility model with IT support. However, the model developed is still not enough to achieve organizational agility. Therefore, in this study will synthesize some previous theories relating to organizational agility using IT support. The result of this study are an analysis of the synthesis of the agility process models of government organizations with IT support.
Detection of Relevant Career Track for Information System Undergraduates Using Profile Matching
Authors: Kusumantara Prisa Marga 
Published: July 2020

AbstractWe are facing the industrial revolution era 4.0 today. The issue of information technology, disruption technology and employment is very urgent. Data from the Indonesian Ministry of Research and Technology and from the Indonesian Ministry of Manpower in 2017 show that Indonesian workers who work not in accordance with their majors are above 50%. The number of jobs relevant graduates are an important value for Information System study program during the assessment by the National Accreditation Agency for Higher Education. So that needs a system to help students for detecting, identifying, and directing them to relevant career track usingDecission Support Systemapproach.Profile Matchingmethod implemented with determining of 17alternatives(career track) and 18criteria(competencies: core=60%, elective=40%) based on IS 2010 curriculum. Whereas weight of each criterion associated with alternatives is stated in 3 variants (significant coverage, some coverage, not required). The highest rank shows that those career track is the most relevant to the student’scriteria(competencies). The other uses of those rank is also able to help students in determining their thesis topic.
Developing and Evaluating a Jejakatua Virtual Campus Tour Prototype Using Auto-stitching Technique
Authors: Suryanto T L M , Wibowo N C 
Published: July 2020

Abstract
This paper describes the design and manufacture of virtual campuses with auto-stitching techniques. The automatic stitching technique using Insta360 allows getting a panoramic view of the 3600 campus area. The creation of a virtual campus is built by each campus to support campus promotion more fully and more closely. The prototype of the Virtual Campus Exploration (Jejakatua) application was implemented at the Faculty of Computer Science UPN “Veterans” Jatim the Jejakatua application page and evaluated by users using a set of questionnaires distributed using Google Forms. The results of testing by the black box test the built system is in accordance with the design and can be operated properly. Studying the questionnaire to 30 respondents from UPN “Veteran” Jatim academicians gave a pretty good average response. So Jejakatua is fully built using the auto-stitching method using Insta360 and is quite feasible to be implemented on Campus.