bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2Y12 inhibitors monotherapy after short course of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized clinical trials including 29 089 patients
Authors: Bianco Matteo , Careggio Alessandro , Destefanis Paola , Luciano Alessia , Perrelli Maria Giulia , Quadri Giorgio , Rossini Roberta , Campo Gianluca , Vizzari Giampiero , D’Ascenzo Fabrizio , Anselmino Matteo , Biondi-Zoccai Giuseppe , Ibáñez Borja , Montagna Laura , Varbella Ferdinando , Cerrato Enrico 
Published: April 2020

Abstract

Aims
Dual antiplatelet therapy (DAPT) reduces the incidence of thrombotic complications at the cost of an increase in bleedings. New antiplatelet therapies focused on minimizing bleeding and maximizing antithrombotic effects are emerging. The aim of this study is to collect the current evidence coming from randomized controlled trials (RCTs) on early aspirin interruption after percutaneous coronary intervention (PCI) and current drug-eluting stent (DES) implantation and to perform a meta-analysis in order to evaluate the safety and efficacy of this strategy.

Methods and results
MEDLINE/PubMed was systematically screened for RCTs comparing P2Y12 inhibitors (P2Y12i) monotherapy after a maximum of 3 months of DAPT (S-DAPT) vs. DAPT for 12 months (DAPT) in patients undergoing PCI with DES. Baseline features were appraised. Major adverse cardiac and cerebrovascular events (MACCE: all causes of death, myocardial infarction, and stroke) and its single composites, stent thrombosis (ST) and Bleeding Academic Research Consortium (BARC) type 3 or 5 were considered and pooled with fixed and random-effects with inverse-variance weighting. A total of four RCTs including a total of 29 089 patients were identified. Overall, the majority of included patients suffered a stable coronary artery disease, while ST-elevation myocardial infarction was the least represented clinical presentation. Complex anatomical settings like left main intervention, bifurcations, and multi-lesions treatment were included although representing a minor part of the cases. At 1-year follow-up, MACCE rate was similar [odds ratio (OR) 0.90; 95% confidence intervals (CIs) 0.79–1.03] and any of its composites (all causes of death rate: OR 0.87; 95% CIs 0.71–1.06; myocardial infarction: OR 1.06; 95% CIs 0.90–1.26; stroke: OR 1.12; 95% CIs 0.82–1.53). Similarly, also ST rate was comparable in the two groups (OR 1.17; 95% CIs 0.83–1.64), while BARC 3 or 5 bleeding resulted significantly lower, adopting an S-DAPT strategy (OR 0.70; 95% CIs 0.58–0.86).

Conclusion
After a PCI with current DES, an S-DAPT strategy followed by a P2Y12i monotherapy was associated with a lower incidence of clinically relevant bleeding compared to 12 months DAPT, with no significant differences in terms of 1-year cardiovascular events.
The power ranking of the members of the Agricultural Committee of the European Parliament
Authors: Fertő Imre , Kóczy László Á , Kovács Attila , Sziklai Balázs R 
Published: April 2020

Abstract
We aim to identify the most influential members of the Agricultural Committee of the European Parliament (COMAGRI). Unlike previous studies that were based on case studies or interviews with stakeholders, we analyse the voting power of MEPs using a spatial Banzhaf power index. We identify critical members: members whose votes are necessary to form winning coalitions. We found that rapporteurs, EP group coordinators and MEPs from countries with high relative Committee representations, such as Ireland, Poland or Romania are powerful actors. Italy emerges as the most influential member state, while France seems surprisingly weak.
Mitochondrial sequences of Rhipicephalus and Coxiella endosymbiont reveal evidence of lineages co-cladogenesis
Authors: Coimbra-Dores Maria João , Jaarsma Ryanne Isolde , Carmo Anderson Oliveira , Maia-Silva Mariana , Fonville Manoj , da Costa Daniela Filipa Ferreira , Brandão Ricardo Manuel Lemos , Azevedo Fábia , Casero María , Oliveira Ana Cristina , Afonso Sónia Maria de Santana , Sprong Hein , Rosa Fernanda , Dias Deodália 
Published: April 2020

ABSTRACT
Rhipicephalus ticks are competent vectors of several pathogens, such as Spotted Fever Group Rickettsiae (SFGR) and many Babesia species. Within this genus, different R. sanguineus s.l. lineages show an unequal vector competence and resistance regarding some pathogenic strains. Current literature supports that tick endosymbionts may play an essential role in the transmission ability of a vector. Indeed, the microbial community of Rhipicephalus seems to be dominated by Coxiella-like endosymbionts (CLE). Still, their co-evolutionary associations with the complicated phylogeny of Rhipicephalus lineages and their transmissible pathogens remain unclear. We performed a phylogenetic congruence analysis to address whether divergent R. sanguineus s.l. lineages had a different symbiont composition. For that, we applied a PCR based approach to screen part of the microbial community present in 279 Rhipicephalus ticks from the Iberian Peninsula and Africa. Our analyses detected several qPCR-positive signals for both SFGR and Babesia species, of which we suggest R. sanguineus-tropical lineage as a natural vector of Babesia vogeli and R. sanguineus-temperate lineage of SFGR. The acquisition of 190 CLE sequences allowed to evaluate co-phylogenetic associations between the tick and the symbiont. With this data, we observed a strong but incomplete co-cladogenesis between CLE strains and their Rhipicephalus tick lineages hosts.
Paternally Inherited P-Element Copy Number Affects the Magnitude of Hybrid Dysgenesis in Drosophila simulans and D. melanogaster
Authors: Serrato-Capuchina Antonio , Wang Jeremy , Earley Eric , Peede David , Isbell Kristin , Matute Daniel R 
Published: April 2020

AbstractTransposable elements (TEs) are repetitive regions of DNA that are able to self-replicate and reinsert themselves throughout host genomes. Since the discovery of TEs, a prevalent question has been whether increasing TE copy number has an effect on the fitness of their hosts. P-elements (PEs) in Drosophila are a well-studied TE that has strong phenotypic effects. When a female without PEs (M) is crossed to a male with them (P), the resulting females are often sterile, a phenomenon called hybrid dysgenesis (HD). Here, we used short- and long-read sequencing to infer the number of PEs in the genomes of dozens of isofemale lines from two Drosophila species and measured whether the magnitude of HD was correlated with the number of PEs in the paternal genome. Consistent with previous reports, we find evidence for a positive correlation between the paternal PE copy number and the magnitude of HD in progeny from ♀M × ♂ P crosses for both species. Other crosses are not affected by the number of PE copies. We also find that the correlation between the strength of HD and PE copy number differs between species, which suggests that there are genetic differences that might make some genomes more resilient to the potentially deleterious effects of TEs. Our results suggest that PE copy number interacts with other factors in the genome and the environment to cause HD and that the importance of these interactions is species specific.
Coseismic and post-seismic gravity disturbance induced by seismic sources using a 2.5-D spectral element method
Authors: Pollitz F F 
Published: April 2020

SUMMARYI present a prescription for computing free-air coseismic and post-seismic gravity changes induced by seismic sources in a viscoelastic earth model. I assume a spherical earth geometry and a 2.5-D calculation, that is, 3-D motions that satisfy the equations of quasi-static equilibrium on a 2-D viscoelastic structure. The prescription permits application to regional gravity computations where a 2-D structure adequately represents the structural heterogeneity. I use a hybrid approach where deformation is computed on a discretized domain and the resulting density perturbations are expanded with spherical harmonics to produce the free-air gravity field. Starting with a solution to the equations of quasi-static displacements in the Laplace transform domain for a given dislocation source, I solve Poisson’s equation using Lagrangian interpolation on spectral element nodes to compute the required deformation quantities that contribute to free-air gravity. A numerical inverse Laplace transform then yields time domain results. This methodology is tested with analytic solutions on a spherically stratified viscoelastic structure, then applied to evaluate the effect of a descending slab of relatively high viscosity on post-seismic gravity in a megathrust faulting setting.
Why Do Only Some Chairs Act as Successful Mediators? Trust in Chairs of Global Climate Negotiations
Authors: Walker Hayley , Biedenkopf Katja 
Published: April 2020

AbstractTrust in the chairs of global negotiations is a decisive factor facilitating successful outcomes. When negotiators trust the chair, they allow her to go beyond her formal procedural role by acting as a mediator, fostering the reaching of agreement. Negotiating parties must consent to a chair assuming substantive mediation functions. They cede parts of their control over the process to the chair when they are confident that the chair is competent and acts in good faith and everyone's interest. In this article, we develop a detailed conceptualization of trust in chairs of global negotiations and demonstrate its impact in two cases of United Nations negotiations that aimed to deliver a universal deal on climate change: the failed 2009 round in Copenhagen, and the 2015 round that culminated in the adoption of the Paris Agreement.
Illiberal Norm Diffusion: How Do Governments Learn to Restrict Nongovernmental Organizations?
Authors: Glasius Marlies , Schalk Jelmer , De Lange Meta 
Published: April 2020

AbstractRecent decades have witnessed a global cascade of restrictive and repressive measures against nongovernmental organizations (NGOs). We theorize that state learning from observing the regional environment, rather than NGO growth per se or domestic unrest, explains this rapid diffusion of restrictions. We develop and test two hypotheses: (1) states adopt NGO restrictions in response to nonarmed bottom-up threats in their regional environment (“learning from threats”); (2) states adopt NGO restrictions through imitation of the legislative behavior of other states in their regional environment (“learning from examples”). Using an original dataset on NGO restrictions in ninety-six countries over a period of twenty-five years (1992–2016), we test these hypotheses by means of negative binomial regression and survival analyses, using spatially weighted techniques. We find very limited evidence for learning from threats, but consistent evidence for learning from examples. We corroborate this finding through close textual comparison of laws adopted in the Middle East and Africa, showing legal provisions being taken over almost verbatim from one law into another. In our conclusion, we spell out the implications for the quality of democracy and for theories of transition to a postliberal order, as well as for policy-makers, lawyers, and civil-society practitioners.
An interactive online dashboard for tracking COVID-19 in U.S. counties, cities, and states in real time
Authors: Wissel Benjamin D , Van Camp P J , Kouril Michal , Weis Chad , Glauser Tracy A , White Peter S , Kohane Isaac S , Dexheimer Judith W 
Published: April 2020

Abstract

Objective
The study sought to create an online resource that informs the public of coronavirus disease 2019 (COVID-19) outbreaks in their area.

Materials and Methods
This R Shiny application aggregates data from multiple resources that track COVID-19 and visualizes them through an interactive, online dashboard.

Results
The Web resource, called the COVID-19 Watcher, can be accessed online (https://covid19watcher.research.cchmc.org/). It displays COVID-19 data from every county and 188 metropolitan areas in the United States. Features include rankings of the worst-affected areas and auto-generating plots that depict temporal changes in testing capacity, cases, and deaths.

Discussion
The Centers for Disease Control and Prevention does not publish COVID-19 data for local municipalities, so it is critical that academic resources fill this void so the public can stay informed. The data used have limitations and likely underestimate the scale of the outbreak.

Conclusions
The COVID-19 Watcher can provide the public with real-time updates of outbreaks in their area.
The effect of Brahman genes on body temperature plasticity of heifers on pasture under heat stress
Authors: Mateescu Raluca G , Sarlo-Davila Kaitlyn M , Dikmen Serdal , Rodriguez Eduardo , Oltenacu Pascal A 
Published: April 2020

Abstract
Bos taurus indicus cattle have the superior ability for the regulation of body temperature during heat stress due to a number of physiological and cellular level adaptive traits. The objectives of this study were to quantify the change in body temperature in heifers with various proportions of Brahman genes per unit increase in heat stress as measured by temperature–humidity index (THI) and to assess how different breed groups responded to varying intensity and duration of heat stress. A total of 299 two-yr-old heifers from six breed groups ranging from 100% Angus to 100% Brahman were evaluated under hot and humid conditions during 2017 and 2018 summer days. Two strategies were used to estimate the plasticity in body temperature of breed groups in response to environmental challenges: 1) a random regression mixed model was used to estimate reaction norm parameters for each breed group in response to a specified environmental heat stress and 2) a repeated measures mixed model was used to evaluate the response to different environmental heat loads. The reaction norm model estimated an intercept and slope measuring the change in body temperature per unit increase in THI environmental heat stress for different breed groups of animals and allowed the identification of genotypes which are robust, with low slope values indicative of animals that are able to maintain normal body temperature across a range of environments. The repeated measures mixed model showed that Brahman cattle have an advantage under moderate or high heat stress conditions but both Angus and Brahman breed groups are greatly affected when heat stress is severe. A critical factor appears to be the opportunity to cool down during the night hours more than the number of hours with extreme THI. With heat stress conditions predicted to intensify and expand into currently temperate zones, developing effective strategies to ensure sustainable beef production systems are imperative. Effective strategies will require the identification of the genes conferring the superior thermotolerance in Brahman cattle.
Effects of incremental exercise and dietary tryptophan supplementation on the amino acid metabolism, serotonin status, stool quality, fecal metabolites, and body composition of mid-distance training sled dogs
Authors: Templeman James R , Thornton Emma , Cargo-Froom Cara , Squires Eli J , Swanson Kelly S , Shoveller Anna K 
Published: April 2020

Abstract
Exercise improves the health of dogs; however, the extreme exertion experienced by sled dogs may lead to variable metabolic and fecal characteristics. Nutritional interventions, such as dietary tryptophan (Trp), may reduce the prevalence of these exercise-induced disturbances. Sporting diets tend to have high crude protein concentrations in contrast to adult maintenance diets and this results in less Trp relative to other amino acids (AA). Therefore, sporting dogs represent an ideal cohort to assess the effects of supplemental Trp. The objective was to evaluate the effects of supplemental dietary Trp and an incremental training regimen on AA and serotonin status, fecal scores and metabolites, and body composition in client-owned Siberian huskies. Sixteen dogs (nine females and seven males) were used, with a mean age of 4.8 ± 2.5 yr and body weight (BW) of 24.3 ± 4.3 kg. Dogs were blocked for sex, age, and BW and randomly allocated into two groups with eight fed a dry extruded control diet (Ctl) and eight fed Ctl supplemented with Trp to reach a Trp:large-neutral AA (LNAA) ratio of 0.075:1 (treatment, Trt). The exercise regimen was designed to increase in distance each week, but weather played a role in setting the daily distance. Each week BW was recorded and food allotments were adjusted to maintain initial BW. Pre and post-exercise blood samples were taken every 3 wk, dogs then received a meal followed by 1, 2, and 4 h post meal blood collections (serum AA, serotonin). Stool collection and scoring occurred each week and body composition was measured on weeks −1 and 11. Serotonin, AA, fecal metabolite, and body composition data were analyzed using PROC MIXED of SAS with dog as a random effect and week and Trt as fixed effects. Stool score data were analyzed using PROC FREQ to compare stool score and Trt, and PROC CORR was used to analyze associations between fecal score, temperature, humidity, and run distance. Dogs on Trt had greater fasted Trp compared with baseline, greater post-meal Trp and serotonin compared with baseline, greater post-meal Trp compared with fasted, and greater post-meal Trp and serotonin compared with Ctl (P &lt; 0.05). Fecal data indicated that Trp improved stool scores (P &lt; 0.05) yet had no effect on fecal metabolites. An overall increase in lean and decrease in fat mass was found (P &lt; 0.05), but Trt had no effect on body composition. Optimization of the dietary Trp:LNAA ratio may help to improve GI health without compromising performance in actively training sled dogs.
Microextraction by Packed Sorbent as a Novel Strategy for Sample Clean-Up in the Determination of Methadone and EDDP in Hair
Authors: Rosado T , Gallardo E , Vieira D N , Barroso M 
Published: April 2020

Abstract
A microextraction by packed sorbent (MEPS) procedure for rapid concentration of methadone and its primary metabolite (EDDP) in hair samples was developed. The miniaturized approach coupled to gas chromatography with tandem mass spectrometry (GC–MS-MS) was successfully validated. Hair samples (50 mg) were incubated with 1 mL of 1 M sodium hydroxide for 45 min at 50°C, time after which the extract was neutralized by adding 100 μL of 20% formic acid. Subsequently, MEPS was applied using a M1 sorbent (4 mg; 80% C8 and 20% strong cation-exchange (SCX)), first conditioned with three 250-μL cycles of methanol and three 250-μL cycles of 2% formic acid. The extract load occurred with nine 150-μL cycles followed by a washing step involving three 50-μL cycles with 3.36% formic acid. For the elution of the analytes, six 100-μL cycles of 2.36% ammonium hydroxide in methanol were applied. The method was linear from 0.01 to 5 ng/mg, for both compounds, presenting determination coefficients greater than 0.99. Precision and accuracy were in accordance with the statements of international guidelines for method validation. This new miniaturized approach allowed obtaining recoveries ranging from 73 to 109% for methadone and 84 to 110% for EDDP, proving to be an excellent alternative to classic approaches, as well as other miniaturized procedures.
Screen Mesh Size for Exclusion of Diaphorina citri (Hemiptera: Liviidae) in Citrus Production
Authors: Ebert Timothy A , Waldo Laura , Stanton Daniel , Schumann Arnold W 
Published: April 2020

Abstract
Huanglongbing is a citrus disease that reduces yield, crop quality, and eventually causes tree mortality. The putative causal agent, Candidatus Liberibacter asiaticus (Rhizobiales: Rhizobiaceae), is vectored by the Asian citrus psyllid, Diaphorina citri Kuwayama. Disease management is largely through vector control, but the insect is developing pesticide resistance. A nonchemical approach to vector management is to grow citrus under screen cages either as bags over individual trees or enclosures spanning many acres. The enclosing screen reduces wind, alters temperature relative to ambient, and excludes a variety of pests that are too large to pass through the screen. Here we evaluated the potential of six screens to exclude D. citri. We conclude that screens with rectangular openings need to limit the short side to no more than 384.3 µm with a SD of 36.9 µm (40 mesh) to prevent psyllids from passing through the screen. The long side can be at least 833 µm, but the efficacy of screens exceeding this value should be tested before using in the field.
Racism and Health-Related Quality of Life in Pediatric Sickle Cell Disease: Roles of Depression and Support
Authors: Mougianis Ifigenia , Cohen Lindsey L , Martin Sarah , Shneider Caitlin , Bishop Meredith 
Published: April 2020

AbstractIntroductionsSickle cell disease (SCD) is the most commonly inherited blood disorder in the United States, and it predominately affects the Black community. SCD is characterized by a number of symptoms, including unpredictable pain, which can lead to hospitalizations. Data indicate that people with SCD experience racism and ample data indicate that racism predicts depressive symptoms and impaired health-related quality of life (HRQOL). In contrast, research suggests that social support might buffer the impact of racism on depression. The aim of this study was to explore associations among perceived racism, depressive symptoms, and HRQOL in adolescents with SCD. Consistent with the literature, it was predicted that perceived racism would predict HRQOL through depression, and social support would moderate the negative impact of racism on depression.MethodsIn a cross-sectional design, 75 inpatient adolescents with SCD completed measures of perceived racism, depressive symptoms, HRQOL, and social support.ResultsThis results indicated a moderated mediation model with greater perceived racism predicting more depressive symptoms, which in turn related to poorer HRQOL; greater access to social support from individuals with SCD strengthened the perceived racism—depressive symptom association.ConclusionsFindings suggest a model for how racism, depressive symptoms, HRQOL, and social support might interact in hospitalized adolescents with SCD. Longitudinal or experimental designs are needed to substantiate directionality among these variables. Results highlight several areas for future research and clinical avenues to improve the welfare of youth with SCD.