bluuebunny/crossref_metadata_2025_split huggingface dataset:
AcquiredRAD51Cpromoter methylation loss causes PARP inhibitor resistance in high grade serous ovarian carcinoma
Authors: Nesic Ksenija , Kondrashova Olga , Hurley Rachel M. , McGehee Cordelia , Vandenberg Cassandra J , Ho Gwo-Yaw , Lieschke Elizabeth , Dall Genevieve , Bound Nirashaa , Shield-Artin Kristy , Radke Marc , Musafer Ashan , Chai Zi Qing , Ghamsari Mohammad Reza Eftekhariyan , Harrell Maria I. , Kee Damien , Olesen Inger , McNally Orla , Traficante Nadia ,   Australian Ovarian Cancer Study, DeFazio Anna , Bowtell David D. , Swisher Elizabeth M. , Weroha S. John , Nones Katia , Waddell Nicola , Kaufmann Scott H. , Dobrovic Alexander , Wakefield Matthew J. , Scott Clare L. ,   Australian Ovarian Cancer Study (AOCS)
Published: December 2020

ABSTRACTWhile loss ofBRCA1promoter methylation has been shown to cause PARP inhibitor (PARPi) resistance in high-grade serous ovarian carcinoma (HGSC), the impacts ofRAD51Cmethylation (meRAD51C) remain unresolved. In this study, three PARPi-responsive HGSC patient-derived xenografts (PDX) withRAD51Cgene silencing and homologous recombination deficiency were found to have either homogeneous or heterogeneous patterns of meRAD51C. PDX could lose meRAD51Cfollowing PARPi treatment (rucaparib/niraparib), where a single unmethylatedRAD51Ccopy was sufficient to drive PARPi-resistance. Genomic profiling revealed this resistance was acquired independently in two distinct PDX lineages. Furthermore, we describe a patient sample where 1/3RAD51Cgene copies lost methylation following neoadjuvant chemotherapy. We show meRAD51Cis a positive predictive biomarker for PARPi response and should be screened for routinely in patients. However, methylation loss in a single gene copy is sufficient to cause PARPi resistance and should be carefully assessed in previously treated patients considering PARPi therapy.
Improving productivity among smallholder farmers in Ghana: does financial inclusion matter?
Authors: Peprah James Atta , Koomson Isaac , Sebu Joshua , Bukari Chei 
Published: December 2020

PurposeDoes financial inclusion matter for productivity among smallholder farmers? The authors answer this question by using the sixth and seventh rounds of the Ghana Living Standard Survey to examine the extent to which financial inclusion affects productivity among smallholder farmers in Ghana.Design/methodology/approachThe study uses a pooled data of the 6th and 7th rounds of the Ghana Living Standard Survey which are national representative data. The authors model an Instrumental Variable (IV) to correct for endogeneity in financial inclusion and a dominance analysis to examine the effects of access to credit, ownership of savings account and insurance product on farmers' productivity.FindingsResults from the study indicate that financial inclusion significantly enhances productivity. Moreover, credit, savings and insurance products influence productivity at various degrees. Thus, expanding the scope of financial services (access to credit, savings and insurance) among smallholder farmers is crucial for inclusive finance and sustainable agricultural production.Practical implicationsThe findings of the study have implications for financial institutions in the design of financial products that the meet the needs of smallholder farmers.Originality/valueSeveral studies have looked at how access to credit influences agricultural productivity in Africa. However, in recent times financial inclusion has been advocated for because it goes beyond mere access to credit. This paper to the best of our knowledge is the first of its kind to examine how financial inclusion could affect agricultural productivity in Ghana.
Corporate social responsibility, job pursuit intention, quality of work life and employee performance: case study from Indonesia controversial industry
Authors: Tarigan Josua , Susanto Amelia Rika Sanchia , Hatane Saarce Elsye , Jie Ferry , Foedjiawati Foedjiawati 
Published: December 2020

PurposeThis paper aims to examine whether companies in Indonesian controversial industries can rely on their corporate social responsibility (CSR) practices to improve potential employees' job pursuit intention, which lead to a higher quality of work life (QWL) and a better performance from their employees.Design/methodology/approachThe target respondents are interns, staff and supervisors of 42 Indonesian listed companies in controversial industries. The data collection method is performed by distributing questionnaires using a seven-point Likert scale. Collected data using partial least squares (PLS) analysis are conducted and tested.FindingsConsistent with the existing result, the authors find out that potential employees have a higher intention to join and accept a job offer from companies with a higher level of CSR practices. Regarding the corporate social responsibility, it is further proven to have a positive effect on employee's quality of work life. More interestingly, the findings of the current study reveal that CSR also affects employee performance (EP), both directly and indirectly, through QWL.Research limitations/implicationsFindings demonstrate that CSR in Indonesian controversial industry represents an important factor for recruiting top employees that lead to the improvement of the employee's quality of work life and performance.Practical implicationsThe findings indicate that enterprises should be more concerned about CSR engagement in attracting new talents, enhancing the quality of work life and cultivating the employee's performance.Originality/valueThis study enhances previous supports and studies on the concept of CSR and human resource management by analyzing the relationship between CSR and employee performance. Previous researches have concentrated their objectives in finding the link between CSR and the financial performance of a company. However, it must be understood that a company's success actually hinges on the performance of one of their greatest assets, the human resources. Additionally, due to the change in generations that will be the job seekers, recruitment strategy to attract job applicants and improve the job pursuit intention (JPI) is now needed more than ever. One of the strategies that Indonesian companies can use to do so is by practicing CSR. Hence, this is the first study in an attempt to observe the overall relationship of the CSR with the job pursuit intention, QWL and EP, especially in the controversial industries. The study will drive companies to intensify their efforts in maintaining good employee performance.
Critical supply chain vulnerabilities affecting supply chain resilience of industrialized construction in Hong Kong
Authors: Ekanayake E.M.A.C. , Shen Geoffrey Qiping , Kumaraswamy Mohan , Owusu Emmanuel Kingsford 
Published: December 2020

PurposeIndustrialized construction (IC) has been recognized as a game-changing approach in Hong Kong (HK). However, the increasing risks of disruptions in IC supply chains (SCs) raise SC vulnerability levels, prompting attention to developing supply chain resilience (SCR). Since SCR is only attainable through overcoming critical supply chain vulnerabilities (CSCV) with enhanced SC capabilities, this study first aimed to determine the most CSCV of ICSCs by addressing this current research gap and practical need.Design/methodology/approachDrawing on SCV factors identified from a precursor literature review, an empirical study of IC in HK was conducted using a questionnaire survey and interviews with industry experts. Focussed significance analysis of the data collected through questionnaire survey enabled the selection of 26 CSCV as appropriate to IC. Next, factor analysis was conducted, enabling the grouping of these CSCV under five components. The results were verified and reinforced by interview findings.FindingsThe results revealed 26 CSCV pertinent to resilient ICSCs in HK with five underlying components: economic, technological, procedural, organizational and production-based vulnerabilities. Loss of skilled labour is the most critical vulnerability, whereas organizational SCV is the most critical component identified.Originality/valueFindings of this study would motivate IC project professionals to appreciate and address the CSCV in the context of five components and thereby develop adequate specific capabilities to successfully withstand these CSCV. This should trigger future studies to map CSCV with appropriate capabilities in developing an envisaged powerful assessment model for evaluating the SCR in IC in HK.
Engineering education development – a business modelling approach
Authors: Kans Mirka 
Published: December 2020

PurposeThe purpose of this article is to promote an innovative approach to education development projects by the application of business modelling tools and methods.Design/methodology/approachThe proposed method is based on tools and methods from the business modelling area, such as stakeholder mapping, SWOT analysis, business modelling canvas and scenario analysis. The applicability of the approach is illustrated by a case study conducted on an engineering programme, where qualitative and quantitative data were gathered through interviews, surveys and workshops.FindingsUtilising business modelling tools for development projects in higher education gives several benefits: (1) knowledge-informed decision making; the methods require good understanding of the current situation as well as possible strategies to be applied, that is data gathering is necessary before decision making; (2) structured decision making by applying a step-by-step approach for the development project; (3) including different stakeholder's perspectives in order to gain a holistic understanding and avoid sub optimisation.Originality/valueThe approach promotes innovation and action driven development rather than a bureaucratic and metric based improvement process. Tools and models from the business area have previously been applied for educational development. However, a holistic business modelling approach for educational development has not yet been applied.
Electro-magnetohydrodynamic flow and heat transfer of a third-grade fluid using a Darcy-Brinkman-Forchheimer model
Authors: Zhang Lijun , Bhatti Muhammad Mubashir , Michaelides Efstathios E. 
Published: December 2020

Purpose
The purpose of this paper is to examine the electro-magnetohydrodynamic behavior of a third-grade non-Newtonian fluid, flowing between a pair of parallel plates in the presence of electric and magnetic fields. The flow medium between the plates is porous. The effects of Joule heating and viscous energy dissipation are studied in the present study.

Design/methodology/approach
A semi-analytical/numerical method, the differential transform method, is used to obtain solutions for the system of the nonlinear differential governing equations. This solution technique is efficient and may be adapted to solve a variety of nonlinear problems in simple geometries, as it was confirmed by comparisons between the results using this method and those of a fully numerical scheme.

Findings
The results of the computations show that the Darcy–Brinkman–Forchheimer parameter and the third-grade fluid model parameter retards, whereas both parameters have an inverse effect on the temperature profile because the viscous dissipation increases. The presence of the magnetic field also enhances the temperature profile between the two plates but retards the velocity profile because it generates the opposing Lorenz force. A graphical comparison with previously published results is also presented as a special case of this study.

Originality/value
The obtained results are new and presented for the first time in the literature.
Awkward ethnography: an untapped resource in organizational studies
Authors: Sløk-Andersen Beate , Persson Alma 
Published: December 2020

PurposeThis article explores the analytical gains of what we refer to as “awkward ethnography.” How might our understanding of organizational phenomena benefit from those unexpected moments when our observations are laughed at, when our questions cause discomfort, or when we feel like a failure? While such instances seem to be an inherent aspect of organizational ethnography, they are often silenced or camouflaged by claims of intentionality. This article takes the opposite approach, arguing for the analytical value of awkwardness.Design/methodology/approachThe authors draw on their respective ethnographic fieldwork in the Danish and Swedish armed forces. Based on observations, participation and interviews in two military units, the analysis focuses on situations that rarely find their way into final research publications. These will be explored as analytically productive material that can provide crucial insights into the organizational context studied.FindingsThe authors’ analysis demonstrates that awkward situations that arise during ethnographic work not only bring about unforeseen insights; they also enable vital analytical opportunities for discovering silent knowledge in the organization which researchers might otherwise not have considered to inquire about or understood the gravity of.Research limitations/implicationsImplied in the suggested methodological approach for ethnographers is an acceptance of awkward situations as productive encounters. This means doing away with ideals for (ethnographic) knowledge production steered by notions of objectivity, instead embracing the affective dimensions of fieldwork.Originality/valueThis research addresses a key, and often silenced, aspect of ethnographic fieldwork, and stresses the unique value of the unintended and unexpected when doing ethnography.
Sources and categories of well-being: a systematic review and research agenda
Authors: Rahman Arafat 
Published: December 2020

PurposeThe purpose of this paper is to identify the sources and categories of well-being from the transformative service research (TSR) domain. The paper also aims to offer a unified framework of sources and categories of well-being and several future research agenda.Design/methodology/approachA systematic literature review method is applied to address the study aims. A three-phase approach has been applied, which produced a total of 70 peer-reviewed empirical studies for the review.FindingsThe analysis has identified five major sources and their underlying sub-sources of well-being. The major sources are organization-, individual-, collective-, service system-, and situation-driven sources. The findings further identified two major categories or well-being showing the capacity and functioning, and subjective appraisals of life conditions. The identified sources and categories of well-being develop a unified framework showing a simplistic path or relations between the sources and the categories.Research limitations/implicationsThe paper offers several research agenda explaining what source-related issues can be addressed for enhancing well-being for various entities. It also adds a proposed schema and research questions for examining the possible relations and influences between the sources of well-being and social well-being of individuals.Practical implicationsPractitioners can get important insights about the matters over which they have little or no control such as the activities, motives and processes that take place in individuals' and collectives' spheres and mechanisms of supports in social networks.Originality/valueThe paper is the first to offer a systematic review on the empirical studies of the TSR domain identifying a comprehensive list of sources and categories of well-being and a resulting unified framework and research agenda.
Information needs and sources of electorates in Nigeria
Authors: Ayinde Lateef Adeshina , Keriafe Ejiro Daniel , Abduldayan Fatima Jibril 
Published: December 2020

PurposeThe purpose of this study was to examine the information needs and sources of electorates in Nigeria and identify challenges electorates faced when obtaining electoral information and news.Design/methodology/approachThe study adopts the description survey design and hypothesized the information needs and sources on demographic variables such as age, sex and academic qualification. Both descriptive and inferential statistics were used. A quantitative approach used based on a questionnaire completed by 236 respondents and a snow ball nonprobability sampling technique was used in this study. The research adapted Wilson 1999 theory of information seeking behavior.FindingsThe findings identified five information needs that are of interest to the electorates: registration of voter, level of security, right as a voter, manifestoes and candidate profile. It was discovered that WhatsApp, Facebook and friends were sources electorates used most in obtaining election-related news and information. The research went further to streamline the number of times such election-related news and information items were sought in a day and week; it was discovered that the manual system still dominated with the print newspaper rather than Twitter, WhatsApp, friends and colleagues and Facebook. The young person used social media most as source of information compared to aged respondents in Nigeria. Thekre is increasing in women participating in political and electoral information. Formal education does not have significant impact on the usage of election information and news. Language barrier, erratic power supply, expensive network service and no knowledge of where to source for information proved to be challenges electorates faced when seeking election-related news and information.Research limitations/implicationsThis research will help to keep abreast of the information electorate needs and how they get such information. This research is limited to small group of electorates.Practical implicationsThis paper includes more information about the electorates and political parties information needs.Social implicationsThe finding was drawn from limited respondents that were ready to participate in the research by responding to various questions in the questionnaire. Therefore, there is need for further study to consider a wider population scope on information-related research of electorate in Nigeria.Originality/valueThis research was carried out by Ayinde Lateef; Keriafe D.E. and Fatima Ghayen.
Knowledge hiding as the dark side of competitive psychological climate
Authors: Han Myat Su , Masood Khola , Cudjoe Dan , Wang Yonggui 
Published: December 2020

PurposePrevious studies suggest that competitive psychological climate at workplace may influence employee's attitudes and behaviors. The purpose of this paper is to explore whether competitive psychological climate leads to increased knowledge-hiding behavior.Design/methodology/approachDrawing upon the conservation of resources theory, we developed a conceptual model which we empirically tested using survey data collected from 296 salespersons from one of the largest distribution market expansion companies in Myanmar.FindingsWe performed hierarchical regression analyses on the data obtained from 296 salespersons to confirm our hypotheses: competitive psychological climate is positively related to knowledge hiding. This relationship becomes weaker when there is high level of organizational justice and high level of optimism.Research limitations/implicationsThe findings shed light on the dark side of competitive psychological climate, such that it translates into knowledge hiding, which is not beneficial for favorable organizational outcomes. To mitigate that, management needs to focus on promoting organizational justice and recruit more optimistic employees.Originality/valueAlthough there are many previous studies on competitive psychological climate and its positive and negative impacts, this paper, to the authors' best knowledge, is the first to study its specific effect on knowledge hiding in the sales context.
The prevalence, risks and associations of problematic cell phone use and sexting on mental health
Authors: Scott David A. , McCormick Katlyn , Smith Kirby , Budlong Emily , Vitonis Alexandra 
Published: December 2020

PurposeThis paper aims to provide an examination of how cell phone use and sexting are impacting society and our mental health.Design/methodology/approachMental health risks are becoming prominent in this worldwide epidemic affecting children, teens and adults. Cell phones are problematic because of their addictive nature and associations with adverse mental health consequences.FindingsBecause of the mental health implications, it is important to study the prevalence, risk factors, effects, associations and treatment options for excessive cell phone use, including sexting.Originality/valueThis conceptual paper explores the impact of cell phone use and sexting on our mental health.
Field evidence for colour mimicry overshadowing morphological mimicry
Authors: Corral‐Lopez Alberto , Varg Javier Edo , Cano‐Cobos Yiselle P. , Losada Rafael , Realpe Emilio , Outomuro David 
Published: December 2020

Abstract

Imperfect mimicry may be maintained when the various components of an aposematic signal have different salience for predators. Experimental laboratory studies provide robust evidence for this phenomenon. Yet, evidence from natural settings remains scarce.

We studied how natural bird predators assess multiple features in a multicomponent aposematic signal in the Neotropical ‘clear wing complex’ mimicry ring, dominated by glasswing butterflies.

We evaluated two components of the aposematic signal, wing colouration and wing morphology, in a predation experiment based on artificial replicas of glasswing butterflies (model) and Polythoridae damselflies (mimics) in their natural habitat. We also studied the extent of the colour aposematic signal in the local insect community. Finally, we inspected the nanostructures responsible for this convergent colour signal, expected to highly differ between these phylogenetically distinct species.

Our results provide direct evidence for a stronger salience of wing colouration than wing morphology, as well as stronger selection on imperfect than in perfect colour mimics. Additionally, investigations of how birds perceive wing colouration of the local insect community provides further evidence that a UV‐reflective white colouration is being selected as the colour aposematic signal of the mimicry ring. Using electron microscopy, we also suggest that damselflies have convergently evolved the warning colouration through a pre‐adaptation.

These findings provide a solid complement to previous experimental evidence suggesting a key influence of the cognitive assessment of predators driving the evolution of aposematic signals and mimicry rings.
Hurdles and Pathways to Regulatory Innovation in Digital Political Campaigning
Authors: Neudert Lisa‐Maria 
Published: December 2020

AbstractTargeted online ads, algorithmic analytics tools, clickbait‐y social media campaigns, big data voter databases—digital technologies have become a cornerstone of contemporary political campaigns in the United Kingdom. Candidates, party campaigners, and a multitude of other registered campaigners embrace digital campaigning for democratic engagement, mobilising voters and electioneering. Yet, in the wake of the Cambridge Analytica scandal, it has become clear that these technologies are vulnerable to abuse and deception. Pressing issues surrounding privacy, transparency, and human rights persist, and systems of electoral law have become ill‐equipped to enforce good behaviour and compliance with the law. Drawing from empirical evidence ahead of the 2019 UK general election, this article examines systemic obstacles to regulatory innovation. The inquiry provides an analysis of key policy challenges affecting elections and democracy, and develops an analytical framework pathways to regulatory innovation in the digital domain across three dimensions: (1) Institutional structures; (2) organisational processes; and (3) regulatory functions. The article puts forward practical policy recommendations to promote regulatory innovation that is tech‐savvy, evidence‐based and future‐proof.