bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of situational context in use continuance after critical exergaming incidents
Authors: Kari Tuomas , Salo Markus , Frank Lauri 
Published: November 2019

AbstractUse continuance is crucial in terms of information systems (IS) success. Previous research has shown that situational context can be central for IS use continuance but has paid limited attention to its specific characteristics. Furthermore, the link between situational context and use continuance has remained unexplored in the novel area of “exergames,” which are defined as digital games requiring physical effort from the player that determines the outcome of the game. Studying exergames is deemed important due to their potential in providing health benefits for users, revenues for providers, and well‐being for societies. However, their potential remains unreached because users tend to discontinue usage after their initial experiences. To address these gaps, we investigate the relationships between specific situational characteristics and use continuance after critical exergaming incidents, in which the user has an exceptionally positive or negative experience. To do this, we quantitatively and qualitatively examined 461 actual critical exergaming incidents. Our findings provide a greater understanding of IS use continuance by revealing new knowledge about the relationships between specific situational characteristics (ie, purpose of use, type of gaming platform, social setting, place, and exertion level) and use continuance. We also offer explanations for these relationships, thus providing a first understanding of the previously unmapped area of how users behave situation‐dependently after critical exergaming incidents. Thus, we contribute both to the general IS continuance literature as well as to the specific area of exergaming. The context specificity of our study matches the calls for heavily contextualised IS research.
Playful learning with sound‐augmented toys: comparing children with and without visual impairment
Authors: Verver Suzanne H. , Vervloed Mathijs P.J. , Yuill Nicola , Steenbergen Bert 
Published: November 2019

AbstractSound‐augmented toys producing factual knowledge were thought to encourage incidental, playful learning in children with visual impairments (VIs). A group of 15 children with VIs and 22 sighted controls played with a sound‐augmented savannah landscape and listened to an informative story in a counterbalanced order. Children's knowledge about savannah animals was assessed at baseline and after each condition in order to quantitatively compare knowledge gains between conditions. Results indicated that children with VIs gained more knowledge than sighted controls from playing with the sound‐augmented toy. Furthermore, offering both the augmented toy and the informative story led to higher knowledge gains than a single medium, especially in children with VIs. Sound‐augmented toys could therefore be a useful addition to the current curriculum in special education for children with VIs.
Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a
Authors: Jiang Bin , Xue Min , Xu Dabao , Song Jiayu , Zhu Shujuan 
Published: November 2019

AbstractIt has been found that long noncoding RNA HOTAIR, microRNA‐130a (miR‐130a) and insulin‐like growth factor 1 (IGF1) expression are associated with ovarian cancer, thus, we hypothesised that the HOTAIR/miR‐130a/IGF1 axis might associate with endocrine disorders and biological behaviours of ovarian granulosa cells in rat models of polycystic ovary syndrome (PCOS). PCOS rat models were established by injection of dehydro‐isoandrosterone, followed by treatment of si‐HOTAIR, oe‐HOTAIR, miR‐130a mimics or miR‐130a inhibitors. Serum hormonal levels were determined to evaluate endocrine conditions. The effect of HOTAIR and miR‐130a on activities of isolated ovarian granulosa cells was assessed, as well as the involvement of IGF1.In the ovarian tissues and granulosa cells of PCOS rat models, highly expressed HOTAIR and IGF1 and poorly expressed miR‐130a were identified. In response to oe‐HOTAIR, serum levels of E2, T and LH were increased and serum levels of FSH were reduced; the proliferation of granulosa cells was reduced and apoptosis was promoted; notably, expression of miR‐130a was reduced while expression of IGF1 was increased. The treatment of si‐HOTAIR reversed the situation. Furthermore, the binding of HOTAIR to miR‐130a and targeting relationship of miR‐130a and IGF1 were confirmed. LncRNA HOTAIR up‐regulates the expression of IGF1 and aggravates the endocrine disorders and granulosa cell apoptosis through competitive binding to miR‐130a in rat models of PCOS. Based on our finding, we predict that competitive binding of HOTAIR to miR‐130a may act as a novel target for the molecular treatment of PCOS.
MicroRNA‐1275 induces radiosensitization in oesophageal cancer by regulating epithelial‐to‐mesenchymal transition via Wnt/β‐catenin pathway
Authors: Xie Congying , Wu Youyi , Fei Zhenghua , Fang Ya , Xiao Shenlan , Su Huafang 
Published: November 2019

AbstractAcquired radioresistance is one of the main obstacles for the anti‐tumour efficacy of radiotherapy in oesophageal cancer (EC). Recent studies have proposed microRNAs (miRNAs) as important participators in the development of radioresistance in various cancers. Here, we investigated the role of miR‐1275 in acquired radioresistance and epithelial‐mesenchymal transition (EMT) in EC. Firstly, a radioresistant cell line KYSE‐150R was established, with an interesting discovery was observed that miR‐1275 was down‐regulated in KYSE‐150R cells compared to the parental cells. Functionally, miR‐1275 inhibition elevated radioresistance in KYSE‐150 cells via promoting EMT, whereas enforced expression of miR‐1275 increased radiosensitivity in KYSE‐150R cells by inhibiting EMT. Mechanically, we demonstrated that miR‐1275 directly targeted WNT1 and therefore inactivated Wnt/β‐catenin signalling pathway in EC cells. Furthermore, WNT1 depletion countervailed the promoting effect of miR‐1275 suppression on KYSE‐150 cell radioresistance through hampering EMT, whereas WNT1 overexpression rescued miR‐1275 up‐regulation‐impaired EMT to reduce the sensitivity of KYSE‐150R cells to radiation. Collectively, our findings suggested that miR‐1275 suppressed EMT to encourage radiosensitivity in EC cells via targeting WNT1‐activated Wnt/β‐catenin signalling, providing a new therapeutic outlet for overcoming radioresistance of patients with EC.
Comparison of dermoscopic features between congenital and acquired acral melanocytic nevi in Korean patients
Authors: Roh D. , Shin K. , Kim W.‐I. , Yang M.‐Y. , Lee W.‐K. , Kim H.‐S. , Ko H.‐C. , Kim B.‐S. , Kim M.‐B. 
Published: November 2019

AbstractBackgroundThe dermoscopic patterns of acral melanocytic nevi (AMNs) are crucial in differentiating them from acral melanoma. Several studies have reported the dermoscopic patterns of acquired acral melanocytic nevi (AAMNs). However, few have investigated the dermoscopic patterns of congenital acral melanocytic nevi (CAMNs).ObjectiveTo compare the clinical and dermoscopic features of CAMNs and AAMNs.MethodsThe present study included 43 patients with CAMNs and 40 with AAMNs. We reviewed their medical records as well as their clinical and dermoscopic findings.ResultsCongenital acral melanocytic nevis were more asymmetrical than AAMNs (P = 0.002) and presented more frequently as comma‐shaped (P = 0.005). Regarding dermoscopic findings, globular pattern (55.8%) was the most common feature of CAMNs, while parallel furrow pattern (37.5%) was the most common feature of AAMNs. The presence of fibrillar, globular, and parallel ridge patterns, and diffuse multi‐component pigmentation differed significantly between the groups (P < 0.05). Furthermore, CAMNs showed melanoma‐specific dermoscopic patterns, such as parallel ridge (18.6%) and diffuse multi‐component pigmentation (25.6%).ConclusionThe dermoscopic patterns of CAMNs and AAMNs differed markedly. In terms of dermoscopic patterns, CAMNs resembled acral melanoma more often than AAMNs did.
Interactions between persons—Knowledge, decision making, and the co‐production of practice
Authors: Loughlin Michael , Buetow Stephen , Cournoyea Michael , Copeland Samantha Marie , Chin‐Yee Benjamin , Fulford K.W.M. 
Published: November 2019

AbstractThere is now broad agreement that ideas like person‐centred care, patient expertise and shared decision‐making are no longer peripheral to health discourse, fine ideals or merely desirable additions to sound, scientific clinical practice. Rather, their incorporation into our thinking and planning of health and social care is essential if we are to respond adequately to the problems that confront us: they need to be seen not as “ethical add‐ons” but core components of any genuinely integrated, realistic and conceptually sound account of healthcare practice.This, the tenth philosophy thematic edition of the journal, presents papers conducting urgent research into the social context of scientific knowledge and the significance of viewing clinical knowledge not as something that “sits within the minds” of researchers and practitioners, but as a relational concept, the product of social interactions. It includes papers on the nature of reasoning and evidence, the on‐going problems of how to ‘integrate’ different forms of scientific knowledge with broader, humanistic understandings of reasoning and judgement, patient and community perspectives. Discussions of the epistemological contribution of patient perspectives to the nature of care, and the crucial and still under‐developed role of phenomenology in medical epistemology, are followed by a broad range of papers focussing on shared decision‐making, analysing its proper meaning, its role in policy, methods for realising it and its limitations in real‐world contexts.
Infection, antibiotic exposure, and risk of celiac disease: A systematic review and meta‐analysis
Authors: Jiang Hai‐yin , Zhang Xue , Zhou Yuan‐yue , Jiang Chun‐min , Shi Yu‐dan 
Published: November 2019

AbstractBackground and AimThere is evidence of a relationship between infection (and the associated antibiotic exposure) and the risk of celiac disease (CD). This study performed a meta‐analysis to investigate this relationship.MethodsTo identify relevant studies, we conducted systematic searches of the PubMed, Embase, and Cochrane databases for articles published up to April 2019. Random effects models were used to determine overall pooled estimates and 95% confidence intervals (CIs).ResultsThe meta‐analysis included 19 observational studies (15 on infection and six on antibiotic exposure). Our results showed that any infection was associated with an increased risk of CD later in life (odds ratio, 1.37; 95% CI: 1.2–1.56; P < 0.001). The I2 was 94% (high heterogeneity among studies). Subgroup analyses suggested that the risk of CD is not affected by the type of infectious agent, timing of exposure, and site of infection. Exposure to antibiotics was also associated with new‐onset CD (odds ratio, 1.2; 95% CI: 1.04–1.39; P < 0.001).ConclusionExposure to early infection or antibiotic appears to increase the odds of developing CD, suggesting that intestinal immune or microbiota dysbiosis may play a role in the pathogenesis of CD. These findings may influence clinical management and primary prevention of CD. However, noncausal explanations for these positive associations cannot be excluded.
Barriers to Prostate Cancer Screening by Men in Sub‐Saharan Africa: An Integrated Review
Authors: Baratedi William M. , Tshiamo Wananani B. , Mogobe Keitshokile D. , McFarland Ditsapelo M. 
Published: November 2019

AbstractPurposeThe aim of this integrative review was to synthesize findings of the published studies on barriers to prostate cancer screening by men in sub‐Saharan Africa.Design and MethodFive‐step Cooper integrative methodology guided this review. Electronic databases, including the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, EBSCOHOST, MEDLINE, ProQuest, and PsycINFO, were searched using specific search terms in combinations to identify relevant articles for the review. Through this process, 83 articles were retrieved and evaluated for duplications and relevance of titles, abstracts, and content. Seventeen articles met the inclusion criteria and were judged to be methodologically adequate. These articles were published between 2008 and 2018.FindingsStudies that met the inclusion criteria were from seven sub‐Saharan countries, including Burkina Faso (n = 1), Ghana (n = 1), Kenya (n = 2), Namibia (n = 1), Nigeria (n = 8), South Africa (n = 3), and Uganda (n = 1). The most common barrier was lack of knowledge, followed by perceptions, attitudes, and beliefs that hindered screening and testing for prostate cancer.ConclusionsThe findings from the integrative review suggest that individuals with low levels of education tend to lack knowledge, cannot comprehend information, and are mistrustful about prostate cancer screening. Low socio‐economic status was also associated with poor prostate screening and testing uptake.Clinical RelevanceEvidence from this review demonstrates that lack of knowledge is a major barrier for prostate screening among men in many parts of sub‐Saharan Africa.
Beyond Random Assignment: Credible Inference and Extrapolation in Dynamic Economies
Authors: HENNESSY CHRISTOPHER A. , STREBULAEV ILYA A. 
Published: November 2019

ABSTRACTWe derive analytical relationships between shock responses and theory‐implied causal effects (comparative statics) in dynamic settings with linear profits and linear‐quadratic stock accumulation costs. For permanent profitability shocks, responses can have incorrect signs, undershoot, or overshoot depending on the size and sign of realized changes. For profitability shocks that are i.i.d., uniformly distributed, binary, or unanticipated and temporary, there is attenuation bias, which exceeds 50% under plausible parameterizations. We derive a novel sufficient condition for profitability shock responses to equal causal effects: martingale profitability. We establish a battery of sufficient conditions for correct sign estimation, including stochastic monotonicity. Simple extrapolation/error correction formulas are presented.
A global epidemic increase of an HPV‐induced tonsil and tongue base cancer – potential benefit from a pan‐gender use of HPV vaccine
Authors: Näsman A. , Du J. , Dalianis T. 
Published: November 2019

AbstractIn 2007, human papillomavirus (HPV) type 16 was finally recognized as a risk factor, besides smoking and alcohol, for oropharyngeal squamous cell carcinoma (OPSCC), including tonsillar squamous cell carcinoma (TSCC), by the International Agency for Research against Cancer. Just before, in 2006, the Food and Drug Administration had approved Gardasil, the first vaccine against HPV16, 18, 6 and 11, for preventive vaccination women against cervical cancer. Concurrently, some Western countries, where smoking was decreasing, disclosed an epidemic increase in the incidence of OPSCC, especially of TSCC and base of tongue cancer (BOTSCC), together accounting for 80–90% of all OPSCCs, and mainly affecting men. The epidemic was later revealed to be due to a rise in HPV‐positive cases, and scientists in the field suggested HPV vaccination also of boys. Globally, there are roughly 96 000 incident OPSCC cases/year of which 20–24% are caused by HPV, thereby accounting for around 22 000 OPSCC cases annually. Of these cases, 80–90% are due to HPV16 infection and would be prevented with the presently registered HPV vaccines. In Western countries, such as Sweden (with almost 400 TSCC and BOTSCC cases per year) and the United States, HPV prevalence in OPSCC is higher and around 70%. HPV vaccination of girls has been initiated in many countries, and the vaccines have been efficient and their side effects limited. HPV vaccination of boys has, however, been the exception, but should definitely not be delayed any further. It would benefit both girls and boys directly, and result in better and more robust herd immunity. Today, we have the possibility to eliminate several high‐risk HPV types in the younger generations and avoid more than 600 000 cancer cases annually worldwide, and this possibility should be embraced by offering global pan‐gender HPV vaccination.
Common, nonsexual masochistic preferences are positively associated with antisocial personality traits
Authors: Sagioglou Christina , Greitemeyer Tobias 
Published: November 2019

AbstractObjectiveBased on prior research linking masochism and antisocial behavior to sensation seeking, we hypothesized that masochistic and antisocial preferences are positively correlated. Besides sensation seeking, we tested whether disgust sensitivity (due to its inhibitory function) and shared social values (e.g., stimulation) accounted for the masochistic‐antisocial link. We additionally examined the link in relation to broad personality factors.MethodSix online and laboratory studies (N = 2,999) with US‐American and European samples.ResultsWe consistently found positive correlations between masochistic enjoyment (e.g., enjoying the burn of spicy food, disgusting jokes, pounding heart, painful massage) and antisocial traits such as subclinical psychopathy, everyday sadism, and low Honesty‐Humility. We observed behavioral correlations in that experienced pleasure of a painful event was positively related to causing another person to feel pain. Shared sensation seeking, low disgust sensitivity, and endorsement of social values such as social power, hedonism, and a stimulating life partially accounted for the masochistic‐antisocial link.ConclusionThe extent to which a person enjoys threatening stimuli on the self is reliably related to how much a person enjoys and evokes others' suffering. Future research could explore the common core that underlies common masochistic and antisocial preferences beyond the mediators tested here.
Methionine promotes the development of hair follicles via the Wnt/β‐catenin signalling pathway in Rex rabbits
Authors: Zhu Yanli , Wu Zhenyu , Liu Hongli , Liu Gongyan , Li Fuchang 
Published: November 2019

AbstractTo investigate the effect and molecular mechanism of methionine (Met) on the growth of hair follicles (HFs) in Rex rabbits. A total of 200 weaning Rex rabbits were divided into four groups and fed varying levels of Met‐supplemented diets. We measured the HF density on dorsal skin and the Wnt/β‐catenin pathway protein expression level. Meanwhile, whole HFs were isolated from Rex rabbit skins and cultured with Met in vitro to measure hair shaft growth. The relationship between Met and the Wnt/β‐catenin signalling pathway was also characterized by using the Wnt/β‐catenin signalling inhibitor, XAV‐939. The results showed that the addition of dietary Met could significantly increase the HF density on dorsal skin (p < .05) and enhance the protein expression level of Wnt10b (p < .05), β‐catenin (p < .05) and DSH (p < .05). Methionine stimulation could also prolong the hair shafts growth in vitro (p < .05). And inhibition of Wnt/β‐catenin signalling using XAV‐939 could eliminate this phenomenon. In summary, Met can increase the density of HFs on dorsal skin in vitro and prolong the hair shaft growth of HFs in vivo via the Wnt/β‐catenin signalling pathway.
Effects of yeast cultures with different fermentation times on the growth performance, caecal microbial community and metabolite profile of broilers
Authors: Sun Zhe , Wang Tao , Aschalew Natnael D. , Zhao Wei , Chen Xue , Zhang Xue‐Feng , Zhen Yu‐Guo , Qin Gui‐Xin 
Published: November 2019

AbstractThe objective of this study was to investigate the effects of yeast culture (YC) on the growth performance, caecal microbial community and metabolic profile of broilers. A total of 350 1‐day‐old healthy Arbor Acres broilers were randomly assigned to seven treatment groups. The first group received a basal diet without YC supplementation, whereas the remaining groups received a basal diet supplemented with either YC fermented for 12, 24, 36, 48 or 60 hr, or a commercial YC product (SZ2). MiSeq 16S rRNA high‐throughput sequencing was used to investigate the bacterial community structure, and gas chromatography–mass spectrometry was used to identify the metabolites in the caeca of broilers. The broilers that received a diet supplemented with YC had a higher average daily gain and average daily feed intake than those received YC‐free or SZ2‐enriched diets. The feed conversion ratio (FCR) of YCs fermented for 24 hr resulted in the best feed efficiency, whereas the FCR of YC fermented for 60 hr resulted in poor feed efficiency (p < .05). In the caeca of broilers, the bacterial communities were well separated, as determined by principal component analysis, and the proportions of the eight genera were significantly different among the seven groups (p < .05). The genus Akkermansia was the most abundant when the diet supplemented with YC fermented for 24 hr (p < .05). Furthermore, the Firmicutes/Bacteroidetes ratio was positively correlated with the FCR in the caecum (r = .47, p < .005). Five differentially expressed metabolites (i.e., L‐alanine, benzeneacetic acid, D‐mannose, D‐arabitol and cholesterol) were identified in the caeca of broilers that received diets supplemented with YCs fermented for 24 or 60 hr. In summary, the different fermentation times of the YCs can markedly improve the growth performance and FCR of broilers by altering the caecal microbial community, and the growth performance which is related to the changes in key metabolic pathways.
Climate seasonality and tree growth strategies in a tropical dry forest
Authors: García‐Cervigón Ana I. , Camarero J. Julio , Cueva Eduardo , Espinosa Carlos I. , Escudero Adrián 
Published: November 2019

AbstractQuestionsDo tree species in seasonally dry tropical forests differ in the timing of their secondary growth? And in their growth rates between consecutive years? If so, how are these contrasting patterns linked to seasonality in climatic variables (temperature, precipitation)? Which is the role of leaf phenology and functional traits as drivers of stem radial increment responses to climate?LocationA Tumbesian tropical dry forest in southern Ecuador.MethodsWe used a 12‐year database of stem radial increments to characterize intra‐ and inter‐annual patterns of secondary growth in 13 co‐existing dominant tree species. For each species, we adjusted an additive model to describe intra‐annual increment patterns and created a mean series of annual increments to describe inter‐annual changes. Adjusted increments were then correlated with monthly temperature and rainfall data over the study period, and also with the crown percentage covered by leaves. The role of functional traits (leaf area, wood density, maximum tree height, seed dry mass) was explored using average trait values per species.ResultsWe observed continuous variation in the seasonality of radial increments, ranging from species that started incrementing their diameter as early as first rains occurred in the season to species that showed delayed responses. Variability in intra‐ and inter‐annual increment patterns was explained by functional traits (leaf area and seed dry mass, and maximum height and wood density, respectively) and leaf phenology, but this variation was not clearly matched with any functional trait configuration. This, combined with the absence of homogeneous responses of annual growth rates to climate, suggests the existence of contrasting strategies that virtually vary in a species‐specific fashion.ConclusionsCo‐existing tree species in seasonally dry tropical forests show different growth strategies to face intra‐ and inter‐annual climate variations, which may increase the resilience of these forests against projected climatic variations.