bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mantle plume dynamics at the rear of a retreating slab
Authors: Mériaux Catherine A , May Dave A , Mansour John , Kaluza Owen 
Published: May 2020

SUMMARY
In this paper, we present 3-D numerical simulations in which a compositional mantle plume rises through a shallow mantle layer at the rear of a retreating slab. The slab–plume buoyancy flux ratio Bs/Bp is varied from 3 to 30 over nine slab–plume simulations. The plume causes an overall decrease of the slab retreat rate from 15 to 7 % in the corresponding range $B_s/B_p=[3,30]$. The retreat rate decrease occurs in two stages: the first decrease occurs remotely when plume and slab are hundreds of kilometres apart; the second decrease is linked to the slab–plume-head impact. Continuous tracking of key positions along the plume head and conduit together with velocity profiling further shows a very close interplay between the conduit and plume head dynamics. In particular, the combination of the slab– and plume(head)–induced flows at the rear of the slab increases the advection and tilt of the conduit and causes its flaring with height in the direction parallel to the trench. As a result, the conduit source slowly drifts away from the slab by hundreds of kilometres and flares by one and a half times its original radius over 30 Myr of plume head spreading. The conduit tilt and flaring result in an increasingly unbalanced azimuthal distribution of the incoming plume flux from the feeding conduit into the head. These changes in the feeding conditions coupled with the mantle flow at the level of the plume head lead to the asymmetric spreading of plume material beneath the plate in the preferential direction that is parallel to the trench. Upon its arrival against the slab, it can be a front of buoyant material set to subduct along the slab width that has widened up to two and a half times its initial dimension. In nature, it is expected to extend from hundreds to thousands of kilometres depending on the slab–plume buoyancy flux ratio. To our knowledge, this study is the first to highlight the inter-relationships between a plume head and its feeding conditions in the plume source region.
Integrating Studies of Anatomy, Physiology, and Behavior into Conservation Strategies for the Imperiled Cyprinid Fishes of the Southwestern United States
Authors: Moran Clinton J , O’Neill Matthew , Gibb Alice C 
Published: May 2020

AbstractOver the last 100 years, fishes native to the Southwestern United States have faced a myriad of biotic and abiotic pressures which has resulted in most being federally listed as endangered or threatened. Most notably, water diversions and the introduction of non-native fishes have been the primary culprits in causing the downfall of native fish populations. We describe how recent studies of morphology, physiology, and behavior yield insights into the failed (occasionally successful) management of this vanishing biota. We describe how understanding locomotor morphologies, physiologies, and behaviors unique to Southwestern native fishes can be used to create habitats that favor native fishes. Additionally, through realizing differences in morphologies and behaviors between native and non-native fishes, we describe how understanding predator–prey interactions might render greater survivorship of native fishes when stocked into the wild from repatriation programs. Understanding fundamental form–function relationships is imperative for managers to make educated decisions on how to best recover species of concern in the Southwestern United States and worldwide.
Experimentally economic analysis of ORC power plant with low-temperature waste heat recovery
Authors: Li Lei , Tao Leren , Li Qingpu , Hu Yongpan 
Published: May 2020

Abstract
Due to the low boiling point of organic fluids, the organic Rankine cycle (ORC) is an effective way to improve the recovery efficiency of low-temperature waste heat. An ORC power plant was established with an actual generating capacity of 16.3 kW. As the ORC technology is in the initial stage of commercial application, a technical and economic analysis has been conducted in this paper. Through analysis of each part investment of the power generation plant, it is found that the ORC system part accounts for 61% of the total initial investment, and the larger the power generation scale, the larger the proportion. An economic model has been proposed to study the economic feasibility of low-temperature industrial waste heat conversion in this plant. The influences of the installation of cooling water system, preheater, superheater, loan ratio, interest rate on electricity production cost (EPC) and profit are analyzed. According to the analysis, the lowest EPC of the plant is 0.46 Yuan/(kW • h).
Psychosis-Relevant Effects of Intravenous Delta-9-Tetrahydrocannabinol: A Mega Analysis of Individual Participant-Data from Human Laboratory Studies
Authors: Ganesh Suhas , Cortes-Briones Jose , Ranganathan Mohini , Radhakrishnan Rajiv , Skosnik Patrick D , D’Souza Deepak Cyril 
Published: May 2020

Abstract

Introduction
There is increasing interest in the relationship between cannabinoids and psychosis. While individual human laboratory studies have been critical in demonstrating that cannabinoids (e.g., delta-9-tetrahydrocannabinol [THC]) can induce acute transient psychosis-like effects in healthy human volunteers, combining data from multiple studies offers a fine-grained view of these effects.

Methods
THC-induced psychosis-relevant effects were examined using a data repository of 10 double-blind, randomized, placebo-controlled, crossover studies with 400 i.v. THC infusions in healthy human volunteers. The Positive and Negative Syndrome scale was used to measure psychotomimetic effects. The profile of symptoms, frequency of a response, its relationship to THC dose and substance use, latent structure in Positive and Negative Syndrome scale response, and the relationships between psychotomimetic and perceptual alteration symptoms were evaluated.

Results
Clinically meaningful increases in positive symptoms were noted in 44.75% infusions; conceptual disorganization, hallucinations, blunted affect, somatic concern, motor retardation, and poor attention were the items most frequently altered by THC. The increase in Positive and Negative Syndrome scale positive symptoms was positively associated with THC dose (beta = 11.13, SE = 4.94, Wald χ 2 = 19.88, P &lt; .001) and negatively associated with frequent cannabis use (beta = −0.575, SE = 0.14, Wald χ 2 = 18.13, P &lt; .001). Furthermore, positive symptoms were strongly correlated with Clinician Administered Dissociative States Scale perceptual alterations score (rs = 0.514, P &lt; .001).

Conclusion
Intravenous administration of THC consistently induces psychotomimetic effects that include symptoms across Positive and Negative Syndrome scale domains. Moreover, healthy individuals who frequently use cannabis have a blunted psychotomimetic response.
Cohort-Derived Machine Learning Models for Individual Prediction of Chronic Kidney Disease in People Living With Human Immunodeficiency Virus: A Prospective Multicenter Cohort Study
Authors: Roth Jan A , Radevski Gorjan , Marzolini Catia , Rauch Andri , Günthard Huldrych F , Kouyos Roger D , Fux Christoph A , Scherrer Alexandra U , Calmy Alexandra , Cavassini Matthias , Kahlert Christian R , Bernasconi Enos , Bogojeska Jasmina , Battegay Manuel ,   Swiss HIV Cohort Study (SHCS)
Published: May 2020

Abstract

Background
It is unclear whether data-driven machine learning models, which are trained on large epidemiological cohorts, may improve prediction of comorbidities in people living with human immunodeficiency virus (HIV).

Methods
In this proof-of-concept study, we included people living with HIV in the prospective Swiss HIV Cohort Study with a first estimated glomerular filtration rate (eGFR) &gt;60 mL/minute/1.73 m2 after 1 January 2002. Our primary outcome was chronic kidney disease (CKD)—defined as confirmed decrease in eGFR ≤60 mL/minute/1.73 m2 over 3 months apart. We split the cohort data into a training set (80%), validation set (10%), and test set (10%), stratified for CKD status and follow-up length.

Results
Of 12 761 eligible individuals (median baseline eGFR, 103 mL/minute/1.73 m2), 1192 (9%) developed a CKD after a median of 8 years. We used 64 static and 502 time-changing variables: Across prediction horizons and algorithms and in contrast to expert-based standard models, most machine learning models achieved state-of-the-art predictive performances with areas under the receiver operating characteristic curve and precision recall curve ranging from 0.926 to 0.996 and from 0.631 to 0.956, respectively.

Conclusions
In people living with HIV, we observed state-of-the-art performances in forecasting individual CKD onsets with different machine learning algorithms.
Effect of ammonia fiber expansion-treated wheat straw and a recombinant fibrolytic enzyme on rumen microbiota and fermentation parameters, total tract digestibility, and performance of lambs
Authors: Ribeiro Gabriel O , Gruninger Robert J , Jones Darryl R , Beauchemin Karen A , Yang Wen Zhu , Wang Yuxi , Abbott D Wade , Tsang Adrian , McAllister Tim A 
Published: May 2020

Abstract
The objective of this study was to evaluate the effect of ammonia fiber expansion (AFEX)-treated wheat straw pellets and a recombinant fibrolytic enzyme on the rumen microbiome, rumen fermentation parameters, total tract diet digestibility, and performance of lambs. Eight rumen cannulated wethers and 60 lambs (n = 15 per diet, 8 rams and 7 ewes) were used in a replicated 4 × 4 Latin square design digestibility study and a complete randomized growth performance study, respectively. Four treatment diets were arranged in a 2 × 2 factorial structure with AFEX wheat straw (0% or 30% AFEX straw pellets on a dietary DM basis replacing alfalfa hay pellets) and fibrolytic enzyme (with or without XYL10C, a β-1,4-xylanase, from Aspergillus niger) as main factors. Enzyme was applied at 100 mg/kg of diet DM, 22 h before feeding. Rumen bacteria diversity Pielou evenness decreased (P = 0.05) with AFEX compared with the control diet and increased (P &lt; 0.01) with enzyme. Enzyme increased (P ≤ 0.02) the relative abundancies of Prevotellaceae UCG-004, Christensenellaceae R-7 group, Saccharofermentans, and uncultured Kiritimatiellaeota. Total protozoa counts were greater (P ≤ 0.04) in the rumen of lambs fed AFEX compared with control, with enzyme reducing (P ≤ 0.05) protozoa counts for both diets. Digestibility of DM did not differ (P &gt; 0.10) among diets, but digestibility of CP was reduced (P = 0.001), and digestibility of NDF and ADF increased (P &lt; 0.05) as AFEX replaced alfalfa. Compared with control, AFEX promoted greater DMI (P = 0.003) and improved ADG up to 42 d on feed (P = 0.03), but not (P = 0.51) over the full ~94-d experiment. Consequently, overall G:F was reduced (P = 0.04) for AFEX when compared with control (0.188 vs. 0.199), but days on feed were lower (P = 0.04) for AFEX (97 vs. 91 d). Enzyme improved DMI of AFEX up to day 70 (P = 0.01), but did not affect DMI of the control diet. Enzyme addition improved ADG of lambs fed both diets in the first 28 d (P = 0.02), but not over the entire feeding period (P ≥ 10). As a result, G:F was improved with enzyme for the first 28 d (P = 0.04), but not overall (P = 0.45). This study shows that AFEX-treated wheat straw can replace alfalfa hay with no loss in lamb growth performance. Additionally, the enzyme XYL10C altered the rumen microbiome and improved G:F in the first month of the feeding.
A Diagnostic Loop-Mediated Isothermal Amplification Method to Distinguish Helicoverpa armigera (Lepidoptera: Noctuidae) From Other Related Species in the New World
Authors: Amano Takayuki , Nomura Masashi 
Published: May 2020

AbstractHelicoverpa armigera (Hübner) is a notorious agricultural pest native to the Old World. Recently, its invasion into South and Central America has become a serious problem in the New World. The rapid detection of invasive pests is essential to eradicate them and prevent establishment. However, an extremely similar species, H. zea (Boddie) distributed in the New World makes identification difficult. Helicoverpa armigera and H. zea have only minor differences in male genitalia to separate them morphologically. Both species are attracted to the same pheromone lure, and it takes considerable time and effort to identify them from bulk samples obtained during trap monitoring. Although several molecular approaches based on PCR have been reported, these methods require expensive equipment and are unsuitable for onsite diagnostics. Here, we developed a rapid and convenient diagnostic method based on the loop-mediated isothermal amplification to distinguish H. armigera from related species: H. zea, H. assulta (Guenée), H. punctigera (Wallengren), and Chloridea virescens (Fabricius). The diagnostic method makes it possible to detect H. armigera within 90 min only using simple equipment. The method also worked with mixed DNA templates containing excess DNA from H. zea at the ratio of 1:999 (H. armigera:H. zea). This method can be an effective tool for onsite diagnostics during monitoring surveys for invasive H. armigera.
Nine Months
Authors: Kingma Elselijn 
Published: May 2020

Abstract
When did we begin to exist? Barry Smith and Berit Brogaard argue that a new human organism comes into existence neither earlier nor later than the moment of gastrulation: 16 days after conception. Several critics have responded that the onset of the organism must happen earlier; closer to conception. This article makes a radically different claim: if we accept Smith and Brogaard’s ontological commitments, then human organisms start, on average, roughly nine months after conception. The main point of contention is whether the fetus is or is not part of the maternal organism. Smith and Brogaard argue that it is not; I demonstrate that it is. This claim in combination with Smith and Brogaard’s own criteria commits to the view that human organisms begin, precisely, at birth.
Using Choice-Based Conjoint Analysis for Creating Effective Outreach Messages to Promote Oak Management
Authors: Radler Barry T , Shaw Bret , Gorby Tricia A 
Published: May 2020

AbstractStudies of woodland owner values, intentions, and actions have advanced understanding of barriers and motivators to active forest management. Social marketing research has likewise offered significant insights into the effective design of persuasive conservation campaigns and importance of factors such as message framing and use of social norms. Yet, evaluation of the attributes of outreach messages designed to encourage woodland owners to take action has received limited attention. We used an innovative marketing research approach, choice-based conjoint analysis, to determine what attributes of outreach messages are most persuasive. This study focused on woodland owners in the Midwest in the context of improving conditions for oak regeneration. We identified the importance of imagery and message source as of primary influence, whereas other attributes such as message framing and social norms were less influential. This study offers insights that can be evaluated with other targeted woodland owner audiences under different management contexts.
Drought effects on the plasticity in vessel traits of two endemic Magnolia species in the tropical montane cloud forests of eastern Mexico
Authors: Rodríguez-Ramírez Ernesto Chanes , Vázquez-García José Antonio , García-González Ignacio , Alcántara-Ayala Othón , Luna-Vega Isolda 
Published: May 2020

AbstractAimsWe aimed to evaluate how climatic fluctuations influence the plasticity of anatomical vessel traits and the width of annual tree-rings of two relict-endemic Mexican Magnolia species. Notwithstanding, few studies have assessed the drought effect on vessel traits in tropical montane cloud trees of eastern Mexico.MethodsThrough digital images of growth rings, we assessed the tree radial growth rate, age of the trees and plasticity in vessel traits regarding climatic fluctuations of the Mexican Magnolia species studied. We compared vessel density, hydraulic diameter and percentage of conductive area in drought years (DY) and non-drought years (NDY) in two Mexican Magnolia species.Important FindingsFor the first time, the plasticity that occurs in porous wood vessel traits to long-term climatic fluctuations was analysed for two endangered Magnolia species (Magnolia vovidesii and M. schiedeana) from two tropical montane cloud forests in Mexico. We found that temperature and precipitation were strongly associated with differences in tree-ring width when DY and NDY were compared. Our analyses revealed that a high plasticity in vessel anatomy of diffuse-porous wood was related to temperature and/or water availability for both Magnolia species studied. We concluded that anatomical adaptations to DY resulted in a substantial reduction in vessel traits when compared with NDY, and that the plastic adaptations played an essential role in water transport and safety for the survival of the studied species during stressful long periods.
The Association of Antibiotic Duration With Successful Treatment of Community-Acquired Pneumonia in Children
Authors: Same Rebecca G , Amoah Joe , Hsu Alice J , Hersh Adam L , Sklansky Daniel J , Cosgrove Sara E , Tamma Pranita D 
Published: May 2020

Abstract

Background
National guidelines recommend 10 days of antibiotics for children with community-acquired pneumonia (CAP), acknowledging that the outcomes of children hospitalized with CAP who receive shorter durations of therapy have not been evaluated.

Methods
We conducted a comparative effectiveness study of children aged ≥6 months hospitalized at The Johns Hopkins Hospital who received short-course (5–7 days) vs prolonged-course (8–14 days) antibiotic therapy for uncomplicated CAP between 2012 and 2018 using an inverse probability of treatment weighted propensity score analysis. Inclusion was limited to children with clinical and radiographic criteria consistent with CAP, as adjudicated by 2 infectious diseases physicians. Children with tracheostomies; healthcare-associated, hospital-acquired, or ventilator-associated pneumonia; loculated or moderate to large pleural effusion or pulmonary abscess; intensive care unit stay &gt;48 hours; cystic fibrosis/bronchiectasis; severe immunosuppression; or unusual pathogens were excluded. The primary outcome was treatment failure, a composite of unanticipated emergency department visits, outpatient visits, hospital readmissions, or death (all determined to be likely attributable to bacterial pneumonia) within 30 days after completing antibiotic therapy.

Results
Four hundred and thirty-nine patients met eligibility criteria; 168 (38%) patients received short-course therapy (median, 6 days) and 271 (62%) received prolonged-course therapy (median, 10 days). Four percent of children experienced treatment failure, with no differences observed between patients who received short-course vs prolonged-course antibiotic therapy (odds ratio, 0.48; 95% confidence interval, .18–1.30).

Conclusions
A short course of antibiotic therapy (approximately 5 days) does not increase the odds of 30-day treatment failure compared with longer courses for hospitalized children with uncomplicated CAP.
In Vitro Activity of Imipenem/Relebactam Against Gram-Negative Bacilli from Pediatric Patients—Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program 2015–2017
Authors: Karlowsky James A , Lob Sibylle H , Young Katherine , Motyl Mary R , Sahm Daniel F 
Published: May 2020

Abstract

Background
Studies describing the activity of imipenem/relebactam against gram-negative bacilli (GNB) isolated from pediatric patients are lacking in the peer-reviewed literature. We address this deficiency by reporting on GNB tested against imipenem/relebactam as part of the Study for Monitoring Antimicrobial Resistance Trends global surveillance program.

Methods
In 2015–2017, 221 laboratories in 59 countries collected 9149 consecutive, aerobic or facultative GNB from pediatric patients (age &lt;18 years) and 100 785 from adult patients with intraabdominal, respiratory, and urinary tract infections. Susceptibility was determined using Clinical and Laboratory Standards Institute (CLSI) broth microdilution methodology and CLSI breakpoints (and US Food and Drug Administration breakpoints for imipenem/relebactam).

Results
The 4 most common species of GNB isolated from pediatric patients were Escherichia coli (40.4%), Pseudomonas aeruginosa (17.1%), Klebsiella pneumoniae (13.9%), and Enterobacter cloacae (4.7%); non-Morganellaceae Enterobacterales (NME) accounted for 70.1% of isolates. Imipenem/relebactam inhibited 97.8% of NME from pediatric patients; susceptibility to imipenem was 1.9% lower, and susceptibility to β-lactam comparators (cefepime, ceftazidime, ceftriaxone, piperacillin/tazobactam) was 9.2-25.2% lower. Imipenem/relebactam inhibited 94.2% of P. aeruginosa from pediatric patients; susceptibility to imipenem was 16.2% lower, and susceptibility to β-lactam comparators was 10.2-15.6% lower. Susceptibility was generally slightly higher for isolates from pediatric than adult patients. All K. pneumoniae carbapenemase (KPC)–positive isolates, 93.3% of multidrug-resistant (MDR) NME isolates, and 70.5% of MDR P. aeruginosa isolates from pediatric patients were susceptible to imipenem/relebactam.

Conclusions
Imipenem/relebactam provides a new treatment option for infections caused by resistant gram-negative bacilli, including KPC-positive NME, MDR NME, and MDR P. aeruginosa.
Limit on the LMC mass from a census of its satellites
Authors: Erkal Denis , Belokurov Vasily A 
Published: May 2020

ABSTRACT
We study the orbits of dwarf galaxies in the combined presence of the Milky Way and Large Magellanic Cloud (LMC) and find six dwarfs that were likely accreted with the LMC (Car 2, Car 3, Hor 1, Hyi 1, Phe 2, and Ret 2), in addition to the Small Magellanic Cloud (SMC), representing strong evidence of dwarf galaxy group infall. This procedure depends on the gravitational pull of the LMC, allowing us to place a lower bound on the Cloud’s mass of $M_{\rm LMC} \gt 1.24\times 10^{11} \, \mathrm{M}_\odot$ if we assume that these are LMC satellites. This mass estimate is validated by applying the technique to a cosmological zoom-in simulation of a Milky Way-like galaxy with an LMC analogue where we find that while this lower bound may be overestimated, it will improve in the future with smaller observational errors. We apply this technique to dwarf galaxies lacking radial velocities and find that Eri 3 has a broad range of radial velocities for which it has a significant chance (&gt;0.4) of having been bound to the Cloud. We study the non-Magellanic classical satellites and find that Fornax has an appreciable probability of being an LMC satellite if the LMC is sufficiently massive ($\text{$\sim$} 2.5\times 10^{11} \, \mathrm{M}_\odot$). In addition, we explore how the orbits of Milky Way satellites change in the presence of the LMC and find a significant change for several objects. Finally, we find that the dwarf galaxies likely to be LMC satellites are slightly smaller than Milky Way satellites at a fixed luminosity, possibly due to the different tidal environments they have experienced.