bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZnWO4:Eu3+ phosphor with intense blue LED excitation: photoluminescence and electron density distribution analysis
Authors: D Sivaganesh , S Saravanakumar , V Sivakumar , S Sasikumar , J NandhaGopal , Ramanathan Rajajeyaganthan 
Published: July 2020

AbstractA high intensity 464 nm excitable ZnWO4:Eu3+ red‐emitting phosphor for warm white lighting applications was prepared using a solid‐state reaction method by varying the dopant Eu3+ concentration. Crystalline purity and phase identification was confirmed and revealed using powder X‐ray diffraction and Rietveld refinement analysis. The surface morphology of Zn1‐xEuxWO4 (x = 0, 0.01, 0.02, 0.03, 0.04 and 0.05) was examined using scanning electron microscopy (SEM) techniques. From SEM analysis, the ZnWO4:Eu3+ phosphor prepared at 1–3% molar Eu3+ concentrations exhibited a small pebble‐like morphology with a smooth surface. On increasing the molar concentration of Eu3+ to >3%, the pebble stone morphology disappeared and a large, smooth irregular polygon‐shaped granular‐like morphology was obtained. Of the higher mol% Eu3+, the 4% Eu3+‐doped ZnWO4 showed the best photoluminescence properties with high intensity and sharp excitation at 395 and 464 nm, followed by red emission centred at 615 nm with excellent CIE coordinates (x = 0.58 and y = 0.41) in the core red region. Elemental composition and chemical state analysis were carried out for the 4% Eu3+‐doped ZnWO4 phosphor using X‐ray photoelectron spectroscopy and energy dispersive X‐ray spectroscopy studies. Based on all the above analyses, the Eu3+‐doped ZnWO4 phosphor was found to be a very efficient red‐emitting phosphor under near‐UV light as well as under visible light excitation and could be used for white LED and field emissive displays applications.
Use of Hantzsch reaction for quantitation of milnacipran as a magic treatment for fibromyalgia syndrome in human plasma and urine
Authors: Mostafa Islam M. , Omar Mahmoud A. , Nagy Dalia M. , Derayea Sayed M. 
Published: July 2020

AbstractA new fluorimetric procedure is described for analysis of milnacipran in its bulk, tablet dosage forms, as well as in biological human samples such as plasma and urine. The suggested method relies on the construction of a derivative with strong fluorescence called dihydropyridine derivative. This derivative resulted from the interaction of the primary amino group in the studied drug and acetylacetone/formaldehyde in McIlvaine buffer (pH 5). The fluorescent dihydropyridine derivative was measured at 470 nm. Influences of experimental variables namely pH, reagent concentration and temperature were examined and optimized. The calibration curve showed linearity over the range of 0.15–1.25 μg ml−1 of milnacipran with an R2 value of 0.9998. The detection limit was 0.02 μg ml−1 and the determination limit was 0.07 μg ml−1. The developed procedure was successfully used in the assay of the studied drug in Avermilan® tablets with excellent selectivity. In addition, the reaction was applied to estimate the drug in spiked human plasma and urine with mean percentage recoveries of 100.04 ± 1.61 and 99.78 ± 0.81% for urine and plasma, respectively.
Institutional pressures and circular economy performance: The role of environmental management system and organizational flexibility in oil and gas sector
Authors: Jain Nikunj Kumar , Panda Abinash , Choudhary Piyush 
Published: July 2020

AbstractThe pressures to make business operations sustainable have been pushing organizations to adopt circular economy (CE) principles. With depleting fossil resources, the oil and gas (O&G) sector is pushed towards recycling limited resources available with it by leveraging CE principles. However, not many studies have been taken up how institutional pressures influence CE‐targeted environmental and economic performances. Drawing on institutional theory, this study examines the moderated‐mediation role of organization flexibility on the effects of institutional pressures on CE performance through environmental management systems (EMSs). Data are collected from 280 firms in Indian O&G sector using questionnaire‐based survey method. The study reveals that organizations leverage EMS to achieve CE performance, and flexible organizations compared with rigid ones are more effective in dealing with coercive pressures by leveraging EMS. These insights may help policymakers to formulate regulatory framework judiciously that encourages firms to adopt EMS in making their operations environmentally sustainable.
Prognostic factors and treatment comparison in small cell neuroendocrine carcinoma of the uterine cervix based on population analyses
Authors: Lin Li‐mei , Lin Qin , Liu Jun , Chu Ke‐xin , Huang Yun‐Xia , Zhang Zong‐Kai , Li Tao , Dai Ya‐Qing , Li Jin‐Luan 
Published: July 2020

AbstractObjectiveWe aimed to assess the impact of the treatment modality on the outcome of small cell neuroendocrine cervical carcinoma (SCNEC) using the Surveillance Epidemiology and End Results (SEER) database.MethodsPatients from the SEER program between 1981 and 2014 were identified. Significant factors for cancer‐specific survival (CSS) and overall survival (OS) were analyzed using the Kaplan‐Meier survival and Cox regression methods.ResultsA total of 503 SCNEC patients were identified. The 5‐year CSS and OS were 36.6% and 30.6%, respectively. The International Federation of Gynecology and Obstetrics (FIGO) stage I to IV distributions was 189 (37.6%), 108 (21.5%), 95 (18.9%), and 111 patients (22.0%), respectively. Within the patients with known treatment strategies, 177 (45.9%) were treated with radical surgery and 209 (54.1%) underwent primary radiotherapy. Local treatment strategies were independent prognostic factor for CSS and OS. The 5‐year CSS for radical surgery and primary radiotherapy was 50.0% and 27.9%, respectively (P < .001). The 5‐year OS for those who received radical surgery and primary radiotherapy was 57.8%, and 29.6%, respectively (P < .001). In FIGO stage I SCNEC, patients treated with radical surgery had superior CSS (P = .001) and OS (P = .003) than those with primary radiotherapy. However, in FIGO stage II and III SCNEC, there were no differences in CSS and OS with respect to different local treatment strategies. Our results also found that the addition of brachytherapy impacted OS in the FIGO stage III SENCE (P = .002). The 5‐year CSS and OS of patients with FIGO IV were only 11.7% and 7.1%, respectively.ConclusionsSCNEC is a rare disease with aggressive clinical behavior. The findings indicate that radical surgery should be suggested for early‐stage SCNEC and combining radiation therapy with brachytherapy should be suitable for patients with advanced stage.
Major Fatty Acid Profiles and Bioactivity of Seed Oils from Ten Tree Peony Cultivars as a Potential Raw Material Source for the Cosmetics and Healthy Products
Authors: Liu Wei , Zhang Tong , Yin Dong‐Xue , Song Peng , Hou Xiao‐Gai , Qi Qiao , Qi Zhong‐Hua 
Published: July 2020

AbstractAs a new woody oleaginous crop, tree peony is now being widely developed and utilized, which attributed to the outstanding oil‐use features regarding the fatty acid profiles and bioactivity. The major fatty acid profiles and bioactivity of seed oils in ten tree peony varieties collected from a common garden were investigated in the present study. The results showed that the oil yields, fatty acid profiles, bioactivity of seed oils existed significant variations among ten tree peony varieties (P<0.05). Considered the application value, ‘Fengdan’ (FD) and ‘Ziban’ (ZB) was the optimal resources as the high oil yields, rich unsaturated fatty acids especially high α‐linolenic acid of 40.46 %, great antioxidant activity with low IC50 values, high ABTS and FRAP values, and strong antimicrobial activity with high DIZ and low MIC/MBC values. The study also confirmed seed oil of tree peony as the potential raw materials sources in functional food, pharmaceuticals and cosmetics for human health.
Persistent hypoglycemia due to an IGF‐II‐secreting malignant pheochromocytoma: a case report and literature review
Authors: Martínez García María , Trincado Aznar Pablo , López Alaminos María Elena , González Fernández Mikel , Alvarado Rosas Almendra , Laclaustra Gimeno Martín 
Published: July 2020

AbstractA malignant pheochromocytoma with IGF‐II‐mediated hypoglycemia is reported; although treatment was cumbersome and evolution unfortunate, this diagnosis must be kept in mind when dealing with NICTH's differential diagnosis.
Automatic capture management may cause unnecessary battery depletion in selective his‐bundle pacing
Authors: Wu Hung‐Pin , Chen Jan‐Yow , Lin Kuo‐Hung , Chang Kuan‐Cheng 
Published: July 2020

AbstractA routine change in the automatic capture management algorithm from “adaptive” to “off or monitor” is required to conserve device longevity in a permanent pacemaker with His‐bundle pacing.
Highly Selective Catalytic Dechlorination of Dichloromethane to Chloromethane over Al−Ti Mixed Oxide Catalysts
Authors: Yoon Wongeun , Lee Seungjun , Noh Yuseong , Park Seongmin , Kim Youngmin , Ju Kim Hyung , Chae Ho‐Jeong , Bae Kim Won 
Published: July 2020

AbstractIn this paper, a series of Al−Ti mixed oxides with different Al/Ti ratios are prepared by a simple sol‐gel method and they are used as active catalysts for selective dechlorination of dichloromethane to chloromethane. The Al−Ti mixed oxide catalyst with the same molar ratio of Al and Ti shows the highest activity in dechlorination of dichloromethane. The strong and abundant Lewis acid sites in the Al−Ti mixed oxides formed along with Al−O−Ti bondings are responsible for the high catalytic activity toward the selective dechlorination reaction in this work. From a kinetic study, the activation energy of this reaction over the optimum Al−Ti mixed oxide catalyst appears to be 59.4 kJ mol−1 based on Langmuir‐Hinshelwood model. The improved catalytic performance suggests that the Al−Ti mixed oxide could be used as the effective catalyst for the highly selective dechlorination of dichloromethane to chloromethane.
Hydrostibination of Alkynes: A Radical Mechanism**
Authors: MacMillan Joshua W. M. , Marczenko Katherine M. , Johnson Erin R. , Chitnis Saurabh S. 
Published: July 2020

AbstractThe addition of Sb−H bonds to alkynes was reported recently as a new hydroelementation reaction that exclusively yields anti‐Markovnikov Z‐olefins from terminal acetylenes. We examine four possible mechanisms that are consistent with the observed stereochemical and regiochemical outcomes. A comprehensive analysis of solvent, substituent, isotope, additive, and temperature effects on hydrostibination reaction rates definitively refutes three ionic mechanisms involving closed‐shell charged intermediates. Instead the data support a fourth pathway featuring open‐shell neutral intermediates. Density‐functional theory (DFT) calculations are consistent with this model, predicting an activation barrier that is in agreement with the experimental value (Eyring analysis) and a rate limiting step that is congruent with the experimental kinetic isotope effect. We therefore conclude that hydrostibination of arylacetylenes is initiated by the generation of stibinyl radicals, which then participate in a cycle featuring SbII and SbIII intermediates to yield the observed Z‐olefins as products. This mechanistic understanding will enable rational evolution of hydrostibination as a synthetic methodology.
Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor
Authors: Pineux Florent , Federico Stephanie , Klotz Karl‐Norbert , Kachler Sonja , Michiels Carine , Sturlese Mattia , Prato Maurizio , Spalluto Giampiero , Moro Stefano , Bonifazi Davide 
Published: July 2020

AbstractThe A3 adenosine receptor (AR) is a G protein‐coupled receptor (GPCR) overexpressed in the membrane of specific cancer cells. Thus, the development of nanosystems targeting this receptor could be a strategy to both treat and diagnose cancer. Iron‐filled carbon nanotubes (CNTs) are an optimal platform for theranostic purposes, and the use of a magnetic field can be exploited for cancer magnetic cell sorting and thermal therapy. In this work, we have conjugated an A3AR ligand on the surface of iron‐filled CNTs with the aim of targeting cells overexpressing A3ARs. In particular, two conjugates bearing PEG linkers of different length were designed. A docking analysis of A3AR showed that neither CNT nor linker interferes with ligand binding to the receptor; this was confirmed by in vitro preliminary radioligand competition assays on A3AR. Encouraged by this result, magnetic cell sorting was applied to a mixture of cells overexpressing or not the A3AR in which our compound displayed indiscriminate binding to all cells. Despite this, it is the first time that a GPCR ligand has been anchored to a magnetic nanosystem, thus it opens the door to new applications for cancer treatment.
Metabolic Analysis at the Nanoscale with Multi‐Isotope Imaging Mass Spectrometry (MIMS)
Authors: Narendra Derek P. , Steinhauser Matthew L. 
Published: July 2020

AbstractIncorporation of a stable‐isotope metabolic tracer into cells or tissue can be followed at submicron resolution by multi‐isotope imaging mass spectrometry (MIMS), a form of imaging secondary ion microscopy optimized for accurate isotope ratio measurement from microvolumes of sample (as small as ∼30 nm across). In a metabolic MIMS experiment, a cell or animal is metabolically labeled with a tracer containing a stable isotope. Relative accumulation of the heavy isotope in the fixed sample is then measured as an increase over its natural abundance by MIMS. MIMS has been used to measure protein turnover in single organelles, track cellular division in vivo, visualize sphingolipid rafts on the plasma membrane, and measure dopamine incorporation into dense‐core vesicles, among other biological applications. In this article, we introduce metabolic analysis using NanoSIMS by focusing on two specific applications: quantifying protein turnover in single organelles of cultured cells and tracking cell replication in mouse tissues in vivo. These examples illustrate the versatility of metabolic analysis with MIMS. © 2020 Wiley Periodicals LLC.Basic Protocol 1: Metabolic labeling for MIMSBasic Protocol 2: Embedding of samples for correlative transmission electron microscopy and MIMS with a genetically encoded reporterAlternate Protocol: Embedding of samples for correlative light microscopy and MIMSSupport Protocol: Preparation of silicon wafers as sample supports for MIMSBasic Protocol 3: Analysis of MIMS data
Parameter Estimation and Reporting in Noncompartmental Analysis of Clinical Pharmacokinetic Data
Authors: Noe Dennis A. 
Published: July 2020

AbstractThe noncompartmental analysis (NCA) of pharmacokinetic (PK) data is important throughout all phases of clinical drug development. Although there are numerous regulatory guidances and articles in the literature concerned with best practices for the modeling of PK data, there are relatively few sources of information on how to conduct a high‐quality NCA. This article provides a systematic review of issues related to the estimation of plasma and urine PK parameters with the intent of encouraging rigor in the performance of NCAs so as to provide reliable and informative analysis results.
Methanol as a Hydrogen Carrier: Kinetic and Thermodynamic Drivers for its CO2‐Based Synthesis and Reforming over Heterogeneous Catalysts
Authors: Frei Matthias S. , Mondelli Cecilia , Short Marion I. M. , Pérez‐Ramírez Javier 
Published: July 2020

AbstractMethanol is an attractive energy vector in a closed loop including its synthesis from CO2 and H2 and on‐demand reforming to the starting feedstocks. Catalytic materials for the two reactions were mostly studied separately, with very few works assessing the feasibility of the same system for both. Here, key kinetic drivers of methanol synthesis (MS) and methanol steam reforming (MSR) were identified for the main catalyst families, with special focus on Cu−ZnO−Al2O3, In2O3, and Pd/ZrO2. It was shown that the relative activity level was preserved in either direction, whereas the distinctly favored (reverse) water‐gas shift modulated selectivity differently. Low selectivity in kinetically controlled MS could be overcome in MSR by exploiting thermodynamics as the driving force, with many catalysts unfit for MS still comprising appealing candidates for MSR and only few being suited for MS as well as MSR. Overall, readily identifiable properties describing catalyst behavior in the forward and backward reactions were highlighted, effectively linking research in the two fields and setting a stronger basis for developing a methanol‐based hydrogen storage unit with a single reactor.
Predicting eating disorders from Internet activity
Authors: Sadeh‐Sharvit Shiri , Fitzsimmons‐Craft Ellen E. , Taylor C. Barr , Yom‐Tov Elad 
Published: July 2020

AbstractObjectiveEating disorders (EDs) compromise the health and functioning of affected individuals, but it can often take them several years to acknowledge their illness and seek treatment. Early identification of individuals with EDs is a public health priority, and innovative approaches are needed for such identification and ultimate linkage with evidence‐based interventions. This study examined whether Internet activity data can predict ED risk/diagnostic status, potentially informing timely interventions.MethodParticipants were 936 women who completed a clinically validated online survey for EDs, and 231 of them (24.7%) contributed their Internet browsing history. A machine learning algorithm used key attributes from participants' Internet activity histories to predict their ED status: clinical/subclinical ED, high risk for an ED, or no ED.ResultsThe algorithm reached an accuracy of 52.6% in predicting ED risk/diagnostic status, compared to random decision accuracy of 38.1%, a relative improvement of 38%. The most predictive Internet search history variables were the following: use of keywords related to ED symptoms and websites promoting ED content, participant age, median browsing events per day, and fraction of daily activity at noon.DiscussionED risk or clinical status can be predicted via machine learning with moderate accuracy using Internet activity variables. This model, if replicated in larger samples where it demonstrates stronger predictive value, could identify populations where further assessment is merited. Future iterations could also inform tailored digital interventions, timed to be provided when target online behaviors occur, thereby potentially improving the well‐being of many individuals who may otherwise remain undetected.
Biodevices using microwells sealed with artificial lipid bilayers: Improvement of sealing performance by protein coating
Authors: Kashimura Yoshiaki , Sumitomo Koji , Nakashima Hiroshi 
Published: July 2020

AbstractThe use of microwells sealed with lipid bilayers is promising for biodevices that utilize protein functions. We have fabricated microwell structures on a Si substrate sealed with lipid bilayers. We have investigated Ca2+ ion transport through α‐hemolysin channels with fluorescent microscopy. However, problems remain as regards achieving the detection of smaller signal such as receptor channels. Ion leakage through the interfacial water layer between the lipid bilayer and the substrate is one of the major hurdles to be overcome. In this paper, we present the mechanism of the ion leakage behavior and then an improved microwell structure that uses bovine serum albumin coating on the device surface to prevent ion leakage from/into the microwells.
Impact of water development on river flows and the catch of a commercial marine fishery
Authors: Broadley Andrew , Stewart‐Koster Ben , Kenyon Rob A. , Burford Michele A. , Brown Christopher J. 
Published: July 2020

AbstractThe growing demand for freshwater resources has led to dam construction and water diversions in a majority of the world's large rivers. With an increasing demand for freshwater, trade‐offs between water allocations and the preservation of ecological connections between terrestrial and marine ecosystems are inevitable. The ecological links formed by rivers flowing into the ocean benefit many commercially fished species. The degree to which different species and the livelihoods of fishers are negatively impacted by changes in river flows due to water extraction or diversion is important for management across terrestrial and marine boundaries. Our objective was to predict how changes in freshwater flows from three wet–dry tropical rivers in northern Australia, that is, the Mitchell, Gilbert, and Flinders rivers, affect the commercial banana prawn (Penaeus merguiensis) catch. We used a novel spatiotemporal Bayesian approach to model the effects of river flows and key climate drivers on banana prawn catch. We then predicted how the loss of flow due to water extraction or diversion affected prawn catch. Our analyses of three water development scenarios found that catch was most impacted by water extraction during low flows. The impact of water extraction was greatest for a scenario with dams on the Mitchell River, where we predicted catch would decline by 53% during a year with low flow. Overall, our results imply that maintenance of low‐level flows is a crucial requirement for sustained fishery yields. We suggest that water managers must balance agricultural demand for water during drier years against the impact of water extraction on prawn fisheries during low‐flow years. Protecting low‐level flows during drier years is a priority for maintaining terrestrial–marine linkages for adjacent marine fisheries.
Synthesis of Size‐Controllable NiCo2S4 Hollow Nanospheres Toward Enhanced Electrochemical Performance
Authors: Zhang Lei , Zhang Haitao , Chu Xiang , Liu Fangyan , Guo Chunsheng , Yang Weiqing 
Published: July 2020

Although the synthesis of novel nanostructured metal sulfides has been well established, further size‐controllable optimization is still valuable to enhance their performance for various applications. Herein, a self‐template method to size‐controllably synthesize the hollow NiCo2S4 nanospheres is reported. Uniformly monodisperse NiCo precursors with diameter widely ranging from 97 to 550 nm are controllably synthesized and subsequently transformed into hollow NiCo2S4 nanospheres through in situ sulfidation. Smaller nanoparticles' diameter results in the hollow NiCo2S4 nanospheres larger surface area and thinner shell thickness and hence provides much more electrochemical active sites as well as facilitate the ion and electron transfer. Consequently, the hollow NiCo2S4 nanospheres—used as the electrode materials in supercapacitors—achieve 19% enhancement of specific capacity from 484.8 to 575.1 C g−1 through lowering the 42.5% diameter of hollow NiCo2S4 nanospheres from 407 to 234 nm. Moreover, the hollow NiCo2S4 nanospheres with 234 nm diameter exhibit superior rate capacity indicated by 49% capacity retention from 1 to 50 A g−1 and excellent cycling stability (77% after 2000 cycles). Furthermore, this method is a potentially general strategy in the size‐controllable synthesis of the metal sulfides hollow nanostructures and results in the remarkable electrochemical applications.