bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propagating Mechanisms of the 2016 Summer BSISO Event: Air‐Sea Coupling, Vorticity, and Moisture
Authors: Wang Shuguang , Sobel Adam H. , Lee Chia‐Ying , Ma Ding , Chen Shuyi , Curcic Milan , Pullen Julie 
Published: November 2020

AbstractDuring the summer of 2016, a boreal summer intraseasonal oscillation (BSISO) event was observed over Southeast Asia and the South China and Philippine seas. Precipitation anomalies associated with this event propagated northward at a speed of 0.5–1° per day from July to August. To understand the mechanisms, a regional atmosphere‐ocean coupled system with the Weather Research and Forecasting (WRF) model and the Hybrid Coordinate Ocean Model (HYCOM) is used to study this BSISO event. The 50‐day‐long coupled simulations reasonably capture large‐scale northward propagation of the event. Coupled simulations with altered air‐sea interaction and atmosphere‐only simulations with prescribed sea surface temperature illuminate the insignificant role of air‐sea interaction within the computation domain in the northward propagation the for this event. Diagnostics of the coupled simulation as well as the ECMWF‐Interim reanalyses indicate that convection and barotropic vorticity are largely in phase north of 5°N during the event. The BSISO convection is accompanied by moisture anomalies whose magnitudes increase as the BSISO propagates northward. Analysis of the moisture budget shows that positive horizontal advection leads positive moisture anomalies on the intraseasonal time scale north of 10°N. The vorticity‐convection relationship, the lead‐lag relationship between moisture and its horizontal advection, and the latitude dependence of each for this BSISO event are consistent with general features of BSISO events composited with ECWMF‐Interim reanalysis and satellite precipitation data sets.
The Long‐Lived and Recent Seismicity at the Lunar Orientale Basin: Evidence From Morphology and Formation Ages of Boulder Avalanches, Tectonics, and Seismic Ground Motion
Authors: Mohanty Rupali , Kumar P. Senthil , Raghukanth S. T. G. , Lakshmi K. J. P. 
Published: November 2020

AbstractThe geologic analysis of lunar tectonic and co‐existing mass wasting features provides important insights into seismicity, seismic ground motion, and the seismic risk of the landed missions. Hence, we performed a detailed geologic mapping of tectonic features and co‐seismic boulder avalanches present at the 930‐km‐diameter lunar Orientale basin. We traced 6869 boulder falls at 141 sites along the basin rings, impact crater walls, and volcanic features. The boulder fields also occur on the graben walls and wrinkle ridges. The boulder trail length and width, and slopes of trail and source region of fallen boulders provide insights into formation processes and transport dynamics. Tens of sites have anomalously larger number of boulder falls and trail density. The cumulative size‐frequency distributions of superimposed impact craters present on the boulder trails provided their model formation ages varying between present and 7.5 Ma with at least eight formation episodes, suggesting the timings of seismic activities along the Cordillera and Outer Rook Rings. Many boulder falls are devoid of superimposed impact craters suggesting their recent origins, including some possibly triggered by the 1972 (MW 2.7) shallow moonquake that occurred near the Cordillera Ring. The formation rates of shallow moonquakes and impact craters along with the seismic ground motion simulations suggest that shallow moonquakes are more dominant sources of ground shaking for triggering the boulder falls in the last 30 million years. Therefore, the Orientale basin has been seismically active for long time and it may be seismically hazardous locally for the future landed missions.
Linking Large‐Eddy Simulations to Local Cloud Observations
Authors: Schemann Vera , Ebell Kerstin , Pospichal Bernhard , Neggers Roel , Moseley Christopher , Stevens Bjorn 
Published: November 2020

AbstractIn order to enhance our understanding of clouds and their microphysical processes, it is crucial to exploit both observations and models. Local observations from ground‐based remote sensing sites provide detailed information on clouds, but as they are limited in dimension, there is no straightforward way to use them to guide large‐scale model development. We show that large‐eddy simulations (LES) performed on similar temporal and spatial scales as the local observations can bridge this gap. Recently, LES with realistic topography and lateral boundary conditions became feasible for domains spanning several 100 km. In this study, we show how these simulations can be linked to observations of the Jülich Observatory for Cloud Evolution (JOYCE) for a 9‐day period in spring 2013. We discuss the advantages and disadvantages of very large versus small but more constrained domains as well as the differences compared to more idealized setups. The semi‐idealized LES include time‐varying forcing but are run with homogeneous surfaces and periodic boundary conditions. These assumptions seem to be the reason why they struggle to represent the observed varying conditions. The simulations using the “realistic” setup are able to represent the general cloud structure (timing, height, phase). It seems that the smaller and more constrained domain allows for a tighter control on the synoptic situation and is the preferred choice to ensure the comparability to the local observations. These simulations together with measures as the shown Hellinger distance will allow us to gain more insights into the representativeness of column measurements in the future.
Diurnal Pumped‐Storage Operation Minimizes Methane Ebullition Fluxes From Hydropower Reservoirs
Authors: Encinas Fernández Jorge , Hofmann Hilmar , Peeters Frank 
Published: November 2020

AbstractHydropower is considered green energy and promoted to reduce greenhouse warming. However, hydropower is typically generated using reservoirs and reservoirs are known to emit substantial amounts of the greenhouse gas methane (CH4) to the atmosphere. In many reservoirs ebullition is the dominant pathway of CH4 emission. We show that continuous diurnal pumped‐storage operation, which combines water pumping into the reservoir typically during the night and water drawdown during high demand of electricity, is beneficial for reducing CH4 ebullition associated with hydropower generation. This conclusion is based on ebullition fluxes and water levels measured over 3 months in Schwarzenbach reservoir located in Germany. The reservoir was managed using three modes of operation: (1) diurnal pumping and turbination, (2) no pumping and no turbination, and (3) diurnal turbination. Cross‐correlation analysis indicates that ebullition fluxes predominantly occur during diurnal water level decrease associated with turbination. Consistently, average ebullition fluxes of CH4 were negligible during Mode (2) and substantial during Modes (1) and (3). During Mode (3) the average CH4 ebullition flux was ~197 mg m−2day−1, ~12 times larger than during Mode (1) (16 mg m−2day−1). Our data indicate that overall CH4 ebullition is about 3 times larger during 51 days of operation consisting of 38 days of no turbination followed by 13 days of diurnal turbination than during 51 days of continuous diurnal pumped‐storage operation. This suggests that continuous diurnal pumped‐storage operation leads to reduced CH4 ebullition from reservoirs and is therefore advantageous compared to modes of operations involving long‐term, large‐amplitude turbination cycles.
Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia
Authors: Molina Juan L. , Thomas Michael L. , Joshi Yash B. , Hochberger William C. , Koshiyama Daisuke , Nungaray John A. , Cardoso Lauren , Sprock Joyce , Braff David L. , Swerdlow Neal R. , Light Gregory A. 
Published: November 2020

AbstractCognitive impairments are pervasive and disabling features of schizophrenia. Targeted cognitive training (TCT) is a “bottom-up” cognitive remediation intervention with efficacy for neurocognitive outcomes in schizophrenia, yet individual responses are variable. Gamma oscillatory measures are leading candidate biomarkers in the development of biologically informed pro-cognitive therapeutics. Forty-two schizophrenia patients were recruited from a long-term residential treatment facility. Participants were randomized to receive either 1 h of cognitive training (TCT, n = 21) or computer games (TAU, n = 21). All participants received standard-of-care treatment; the TCT group additionally completed 30 h of cognitive training. The auditory steady-state response paradigm was used to elicit gamma oscillatory power and synchrony during electroencephalogram recordings. Detailed clinical and cognitive assessments were collected at baseline and after completion of the study. Baseline gamma power predicted cognitive gains after a full course of TCT (MCCB, R2 = 0.31). A change in gamma power after 1-h TCT exposure predicted improvement in both positive (SAPS, R2 = 0.40) and negative (SANS, R2 = 0.30) symptoms. These relationships were not observed in the TAU group (MCCB, SAPS, and SANS, all R2 < 0.06). The results indicate that the capacity to support gamma oscillations, as well as the plasticity of the underlying ASSR circuitry after acute exposure to 1 h of TCT, reflect neural mechanisms underlying the efficacy of TCT, and may be used to predict individualized treatment outcomes. These findings suggest that gamma oscillatory biomarkers applied within the context of experimental medicine designs can be used to personalize individual treatment options for pro-cognitive interventions in patients with schizophrenia.
Tilapia lake virus downplays innate immune responses during early stage of infection in Nile tilapia (Oreochromis niloticus)
Authors: Mugimba Kizito K. , Lamkhannat Mustapha , Dubey Saurabh , Mutoloki Stephen , Munang’andu Hetron M. , Evensen Øystein 
Published: November 2020

AbstractTilapia lake virus (TiLV) causes high mortality and high economic losses in tilapines. We describe an experimental challenge study focusing on early post challenge innate immune responses. Nile tilapia (Oreochromis niloticus) were infected with 105 TCID50/mL TiLV intraperitoneally, followed by virus quantification, histopathology and gene expression analysis in target (brain/liver) and lymphoid (spleen/headkidney) organs at 3, 7, 12, 17, and 34 days post challenge (dpc). Onset of mortality was from 21 dpc, and cumulative mortality was 38.5% by 34 dpc. Liver and kidney histopathology developed over the period 3–17 dpc, characterized by anisocytosis, anisokaryocytosis, and formation of multinucleated hepatocytes. Viral loads were highest at early time (3 dpc) in liver, spleen and kidney, declining towards 34 dpc. In brain, viral titer peaked 17 dpc. Innate sensors, TLRs 3/7 were inversely correlated with virus titer in brain and headkidney, and IFN-ß and Mx showed a similar pattern. All organs showed increased mRNA IgM expression over the course of infection. Overall, high virus titers downplay innate responses, and an increase is seen when viral titers decline. In silico modeling found that TiLV segments 4, 5 and 10 carry nucleolar localization signals. Anti-viral effects of TiLV facilitate production of virus at early stage of infection.
Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
Authors: Ebert Thomas , Painer Johanna , Bergman Peter , Qureshi Abdul Rashid , Giroud Sylvain , Stalder Gabrielle , Kublickiene Karolina , Göritz Frank , Vetter Sebastian , Bieber Claudia , Fröbert Ole , Arnemo Jon M. , Zedrosser Andreas , Redtenbacher Irene , Shiels Paul G. , Johnson Richard J. , Stenvinkel Peter 
Published: November 2020

AbstractExperimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.
Different response of the taxonomic, phylogenetic and functional diversity of birds to forest fragmentation
Authors: Bełcik Michał , Lenda Magdalena , Amano Tatsuya , Skórka Piotr 
Published: November 2020

AbstractHabitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (species richness), phylogenetic and functional diversity of birds to forest fragmentation. We hypothesised that with increasing forest patch isolation and/or decreasing patch size the diversity of birds decreases but only if certain thresholds of fragmentation metrics are reached. Specifically, we hypothesized that out of the three diversity components the taxonomic diversity is the most sensitive to forest fragmentation, which means that it starts declining at larger patch size and higher connectivity values than phylogenetic and functional diversity do. We compared the three biodiversity metrics of central European bird species in a large set of forest patches located in an agricultural landscape. General additive modeling and segmented regression were used in analyses. Habitat fragmentation differentially affected studied biodiversity metrics. Bird taxonomic diversity was the most responsive towards changes in fragmentation. We observed an increase in taxonomic diversity with increasing patch area, which then stabilized after reaching certain patch size. Functional diversity turned out to be the least responsive to the fragmentation metrics and forest stand characteristics. It decreased linearly with the decreasing isolation of forest patches. Apart from the habitat fragmentation, bird taxonomic diversity but not phylogenetic diversity was positively associated with forest stand age. The lower share of dominant tree species, the highest taxonomic diversity was. While preserving a whole spectrum of forests (in terms of age, fragmentation and size) is important from the biodiversity perspective, forest bird species might need large, intact, old-growth forests. Since the large and intact forest becomes scarcer, our study underscore their importance for the preservation of forest specialist species.
Renal function is associated with blood neurofilament light chain level in older adults
Authors: Akamine Shoshin , Marutani Noriko , Kanayama Daisuke , Gotoh Shiho , Maruyama Riki , Yanagida Kanta , Sakagami Yukako , Mori Kohji , Adachi Hiroyoshi , Kozawa Junji , Maeda Norikazu , Otsuki Michio , Matsuoka Takaaki , Iwahashi Hiromi , Shimomura Iichiro , Ikeda Manabu , Kudo Takashi 
Published: November 2020

AbstractNeurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.
Analysis of the three dimensional structure of the kidney glomerulus capillary network
Authors: Terasaki Mark , Brunson Jason Cory , Sardi Justin 
Published: November 2020

AbstractThe capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized. We therefore devised a new approach in which an automated tape collecting microtome (ATUM) was used to collect 0.5 μm thick serial sections from fixed mouse kidneys. The sections were imaged by scanning electron microscopy at ~ 50 nm/pixel resolution. With this approach, 12 glomeruli were reconstructed at an x–y–z resolution ~ 10 × higher than that of paraffin sections. We found a previously undescribed no-cross zone between afferent and efferent branches on the vascular pole side; connections here would allow blood to exit without being adequately filtered. The capillary diameters throughout the glomerulus appeared to correspond with the amount of blood flow within them. The shortest path (minimum number of branches to travel from afferent to efferent arterioles) is relatively independent of glomerular size and is present primarily on the vascular pole size. This suggests that new branches and longer paths form on the urinary pole side. Network analysis indicates that the glomerular network does not form by repetitive longitudinal splitting of capillaries. Thus the 3D structure of the glomerular capillary network provides useful information with which to understand glomerular function. Other tissue structures in the body may benefit from this new three dimensional approach.
A novel methylation signature predicts radiotherapy sensitivity in glioma
Authors: Feng Yuemei , Li Guanzhang , Shi Zhongfang , Yan Xu , Wang Zhiliang , Jiang Haoyu , Chen Ye , Li Renpeng , Zhai You , Chang Yuanhao , Zhang Wei , Yuan Fang 
Published: November 2020

AbstractGlioblastoma (GBM) is the most common and malignant cancer of the central nervous system, and radiotherapy is widely applied in GBM treatment; however, the sensitivity to radiotherapy varies in different patients. To solve this clinical dilemma, a radiosensitivity prediction signature was constructed in the present study based on genomic methylation. In total, 1044 primary GBM samples with clinical and methylation microarray data were involved in this study. LASSO-COX, GSVA, Kaplan–Meier survival curve analysis, and COX regression were performed for the construction and verification of predictive models. The R programming language was used as the main tool for statistical analysis and graphical work. Via the integration analysis of methylation and the survival data of primary GBM, a novel prognostic and radiosensitivity prediction signature was constructed. This signature was found to be stable in prognosis prediction in the TCGA and CGGA databases. The possible mechanism was also explored, and it was found that this signature is closely related to DNA repair functions. Most importantly, this signature could predict whether GBM patients could benefit from radiotherapy. In summary, a radiosensitivity prediction signature for GBM patients based on five methylated probes was constructed, and presents great potential for clinical application.
Variation of soil organic carbon and physical properties in relation to land uses in the Yellow River Delta, China
Authors: Jiao Shuying , Li Junran , Li Yongqiang , Xu Ziyun , Kong Baishu , Li Ye , Shen Yuwen 
Published: November 2020

AbstractSoil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil degradation and carbon loss. The objective of this study is to evaluate the variation of soil texture, aggregates stability, and soil carbon affected by land uses. For each land use unit, we collected soil samples from five replicated plots from “S” shape soil profiles to the depth of 50 cm (0–5, 5–10, 10–20, 20–30, and 30–50 cm). The results showed that the grassland had the lowest overall sand content of 39.98–59.34% in the top 50 cm soil profile. The content of soil aggregates > 0.25 mm (R0.25), mean weight diameter and geometric mean diameter were significantly higher in grassland than those of the arable and forest land. R0.25, aggregate stability in arable land in the top 30 cm were higher than that of forest land, but lower in the soil profile below 20 cm, likely due to different root distribution and agricultural practices. The carbon management index (CMI) was considered as the most effective indicator of soil quality. The overall SOC content and CMI in arable land were almost the lowest among three land use types. In combination with SOC, CMI and soil physical properties, we argued that alfalfa grassland had the advantage to promote soil quality compared with arable land and forest land. This result shed light on the variations of soil properties influenced by land uses and the importance to conduct proper land use for the long-term sustainability of the saline-alkali reclamation region.
Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
Authors: Correa-Fiz Florencia , Neila-Ibáñez Carlos , López-Soria Sergio , Napp Sebastian , Martinez Blanca , Sobrevia Laia , Tibble Simon , Aragon Virginia , Migura-Garcia Lourdes 
Published: November 2020

AbstractMedicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.