bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis
Authors: Gunawan Atma , Fajar Jonny Karunia , Tamara Fredo , Mahendra Aditya Indra , Ilmawan Muhammad , Purnamasari Yeni , Kartini Dessy Aprilia , Winoto Eden Suryoiman , Saifillah Efriko Septananda , Wulandari Dewi Sri , Krisna Pratista Adi , Mayasari Ema Dianita , Dantara Tri Wahyudi Iman , Wicaksono Ramadi Satryo , Soeatmadji Djoko Wahono 
Published: April 2020

Background: While it has been known that the development of chronic kidney disease (CKD) and age-related cognitive impairment involves several mediators, the evidence in clinical practice only reveals nitride oxide synthase (NOS) and klotho. However, the evidence for this topic is conflicted. The aim of this study was to assess the role of NOS and klotho single nucleotide polymorphisms (SNPs) in the pathogenesis of CKD and age-related cognitive impairment. Methods: We performed a meta-analysis during October to December 2019. Paper collection was performed in major scientific websites, and we extracted information of interest from each paper. Data were analyzed using a Z-test with either random or fixed effect model. Results: Our initial assessment identified NOS3 G894T, NOS3 T786C, NOS3 4b/4a, klotho (KL) G395A, and KL C1818T as the gene candidate for our meta-analysis. Our pooled calculation revealed that NOS3 G894T was associated with the risk of both age-related cognitive impairment and CKD. Increased susceptibility to age-related cognitive impairment was observed in the GG genotype, and increased risk of CKD was found in patients with a single T allele and TT genotype for NOS3 nucleotide 894. For NOS3 4b/4a, increased risk of CKD was only found in 4a4a genotype. For NOS3 T786C, we failed to show the association with both CKD and age-related cognitive impairment. Subsequently, for KL G395A, A allele and GA genotype were found to correlate with increased susceptibility to CKD, while its correlation to age-related cognitive impairment was failed to clarify. For KL C1818T, our analysis failed to find the correlation with the risk of CKD. Conclusions: Our results reveal that the NOS3 G894T gene polymorphism has a crucial role in the pathogenesis of both CKD and age-related cognitive impairment.
Arab resistance in the diaspora: Comparing the Saudi dissident and the Egyptian whistleblower
Authors: Khamis Sahar , Fowler Randall 
Published: April 2020

Abstract
While much research on Arab and Muslim diasporas in the West focuses on the War(s) on Terror, in this article, we explore how two particular diasporic groups, Egyptian and Saudi activists, work to shape public perceptions of the authoritarian regimes in their countries of origin. Contextualizing the efforts of these activists in the post-Arab Spring political and mediated environments, we investigate how these political exiles employ communication to disrupt, expose and resist the resurgent authoritarianism taking root in their countries of origin. Using a comparative framework, we analyse the discourse of two prominent activists, Mohamed Ali and Omar Abdelaziz, to illustrate the larger dynamics of online cyberactivism amongst these diasporic groups. Critically, we argue, the differences in these two activists’ communicative practices demonstrate how ostensibly similar resistance movements may lead to disparate political outcomes, as their calls for change diverge when it comes to issues of reform versus revolution. In doing so, we seek to complicate overly simplistic understandings of Arab anti-authoritarian resistance taking place online in the post-Arab Spring era.
From circus acts to violent clowns: The parasite as performer
Authors: Jürgens Anna-Sophie , Maier Alexander G. 
Published: April 2020

Abstract
With the growing awareness of the contribution of parasites to life, their influences on humans also become clearer. The parasite's footprints can be seen everywhere, in genetics, epidemiology, medicine, history and, as this article clarifies, parasites play a vivid part in our cultural imagination surrounding popular entertainment. Drawing and expanding on Michel Serres' and Enid Welsford's discussions of the parasite as a cultural force, this article explores the line of filiation and interplay between biological parasites, circus arts and their comic emblem, the clown, in different narratives and media. It documents not only fantasies of a collaborative relationship between flea performers and their 'masters', and of the relationship between clowns and parasites, both of which are mischievous 'characters', but also circus-related imaginaries of parasitic remote control.
Resettlement Processes in the Ukrainian SSR during the Holodomor (1932–34)
Authors: Rozovyk Olesia 
Published: April 2020

This article, based on archival documents, reveals resettlement processes in the Ukrainian Soviet Socialist Republic in 1932–34, which were conditioned by the repressive policy of the Soviet power. The process of resettlement into those regions of the Soviet Ukraine where the population died from hunger most, and which was approved by the authorities, is described in detail.
It is noted that about 90,000 people moved from the northern oblasts of the Ukrainian SSR to the southern part of the republic. About 127,000 people arrived in Soviet Ukraine from the Byelorussian Soviet Socialist Republic (BSSR) and the western oblasts of the Russian Soviet Federative Socialist Republic (RSFSR). The material conditions of their residence and the reasons for the return of settlers to their previous places of inhabitance are described.
I conclude that the resettlement policy of the authorities during 1932–34 changed the social and national composition of the eastern and southern oblasts of Ukraine.
STRATEGI PENINGKATAN KOMPETENSI LULUSAN PERGURUAN TINGGI MELALUI STUDI PELACAKAN ALUMNI (TRACER STUDY)
Authors: Rofaida Rofi , Gautama Budhi Pamungkas 
Published: April 2020

Tujuan penelitian ini adalah untuk mengetahui gambaran mengenai kompetensi yang dimiliki lulusan, mengetahui gambaran mengenai kompetensi tuntutan industri, mengetahui gambaran mengenai kesenjangan kompetensi yang dimiliki lulusan dengan tuntutan dunia kerja/industri, dan menentukan strategi penjaminan mutu perguruan tinggi didasarkan pada hasil studi pelacakan lulusan (tracer study). Penelitian yang dilakukan adalah penelitian kualitatif. Unit analisis adalah lulusan Program Studi Manajemen Fakultas Pendidikan Ekonomi dan Bisnis Universitas Pendidikan Indonesia. Metodepengambilansampelyangdigunakanadalahpurposivesamplingdengansampel100 orang lulusan. Metode penelitian yang digunakan adalah metode survei deskriptif. Hasil penelitian menunjukkan bahwa kompetensi yang masih harus ditingkatkan adalah bahasa Inggris, komputer, kerjasama tim, komunikasi tertulis, komunikasi lisan, pemberdayaan masyarakat, dan kepemimpinan. Peningkatan kualitas pendidikan di program studi Manajemen dapat dilakukan melalui peningkatan kualitas pada pendidikan, penelitian, dan pengabdian kepada masyarakat, serta kerjasama dengan industri. Kata Kunci: kompetensi lulusan; penjaminan mutu perguruan tinggi; studi pelacakan lulusan
PENGEMBANGAN BLENDED LEARNING DENGAN MODEL FLIPPED CLASSROOM
Authors: Sutisna M. Ridwan , Mulyadi Dadi , Alinawati Muthia 
Published: April 2020

AbstrakPengembangan pembelajaran dengan melibatkan teknologi menjadi salah satu dampak pesatnya perkembangan teknologi. Blended learning menjadi salah satu opsi yang dapat diadaptasi, namun upaya pengembangan pembelajaran menggunakan blended learning masih belum masif. Penelitian ini mencoba untuk mengembangkan salah satu model desain pembelajaran menggunakan metode penelitian Design and Development (DnD). Hasil dari penelitian ini yaitu model GALE yang dapat digunakan untuk mengembangkan pembelajaran menggunakan strategi blended learning. Model GALE merupakan turunan yang dikembangkan dari model instruksional ADDIE, memiliki empat tahapan yaitu Goal Analysis, Activity Plan, Learning Resources Development, dan Evaluate and Reflection. Dalam penerapannya, blended ini dilakukan di mata kuliah penelitian dan pengembangan teknologi pendidikan pada semester tujuh di program studi teknologi pendidikan. Sekaligus smemanfaatkan fasilitas learning management system yang dimiliki oleh UPI yaitu spot.upi.edu. Hasil dari pengembangan pembelajaran ini dapat menunjang pembelajaran sesuai dengan kebutuhan blended learning yang telah dikembangkan. Selain itu, penelitian ini diharapkan mampu memberikan best practice pengembangan blended learning, selain juga menyajikan model GALE sebagai alternatif model pengembangannya. AbstractThe development of instruction involving technology is one of the effects of the technology rapid development. Blended learning strategy is an option that can be adapted for instructions. However, efforts to develop instruction using blended learning are still not massive enough. This study tries to develop one of the learning design models using the Design and Development (DnD) research method. The results of this study are GALE models that can be used to develop learning using the blended learning strategy. The GALE model is a derivative developed from the ADDIE instructional model. It has four stages, start with the Goal Analysis, Activity Plan, Learning Resources Development, and Evaluate and Reflection. In its implementation, this instructional design model for blended learning strategy is carried out in the research and development of educational technology courses in the seventh semester in Educational Technology program. While at the same time utilizing the Learning Management System (LMS) facility owned by UPI, namely spot.upi.edu. The results of developing this instructional design model can support learning appropriately match to the blended learning needs that have been developed. In addition, this research is expected to be able to provide best practice for the development and implementation of blended learning strategy, and also to presenting the GALE model as an alternative development model.
How Does the Budget Deficit Affect Inflation Rate – Evidence from Western Balkans Countries
Authors: Durguti Esat Ali 
Published: April 2020

The main purpose of this study is to investigate if determinants that we selected in our analysis have any effects on inflation rate in Western Balkans Countries[1] by using panel data for the period of 2001-2017, in yearly basis in total of 102 observation. The study used quantitative analysis approach and secondary data by applying the multivariate time series, respectively vector error correction model [VECM]. Multivariate time series was applied to investigate whether the budget deficit and other explanatory variable have any significant impact on inflation rate. The results from our analysis shows that three of four determinates that we used are significant on inflation rate. The model summaries statistics for inflation rate which shows that inflation rate has a moderate correlation with explanatory variables that we used in our model, that explanatory variables explain 45.5 percent of dependent variable and we can conclude that a model is a proper and fit. The results suggest that one percent point increase in budget deficit to GDP ratio is associated with about a 9.34 percent point increase in inflation rate. The overall inference is that the ratios that we selected has a significant influence on the inflation rate in Western Balkans Countries.

[1] Western Balkans Countries: Albania, Bosnia & Hercegovina, Kosovo, Montenegro, North Macedonia and Serbia.
Brief: Planning for Information Technology in E&P
Authors: Hunter Les R. 
Published: April 2020

Summary
This paper provides a framework for planning and investment that integrates the needs of the business and the requirements for information technology (IT). It explains how the application of vision, integrated planning, and portfolio evaluation can encourage a better analysis, thereby ensuring more appropriate investment.

Definitions and Terminology
Table 1 highlights the main topics in this paper. It also outlines checkpoints for the information planning process.
Fig. 1 presents information planning as an integral part of the total business planning process. Business strategies, objectives, and constraints set the overall business environment. All aspects of investment and expenditures should be put in the context of business priorities. The core business investment in wells or facilities and support activities in research, IT, human resources, etc., should be aligned with and prioritized within the broader business objectives. The key deliverables from the integrated planning process are the business plans and the budgets.
IT can be defined as any technology which enables the acquisition, modification, use, and deletion of data or information. In the broadest sense, IT includes non-computer-related data or information like library records that increasingly are available in electronic form. The Information Planning process (exercise) sets the direction and efforts for IT as they relate to business requirements. The total effort from the information planning process is documented in an Information Plan.
The planning process should establish key principles and directions for IT, i.e., set the technical strategies. These principles should define the direction and guidelines for applying IT in the business and how it will migrate or change over the planning cycle.

Alignment of the Business and IT
Initial efforts in the information planning process should identify the business strategies and the enabling IT. This can be a relatively complex task but the final check on the quality of an information plan is whether the correct investment is being made to meet corporate objectives. For example, some new E&P technologies, like 3D petrophysics (interwell logging), will increase the volume of data handled, processed, and stored by several orders of magnitude. Tables 2 and 3 give further examples.
Clean Energy - Preparing Today for Tomorrow's Challenges
Authors: Bowlin Michael R. 
Published: April 2020

Published in Oil & Gas Executive Report, Volume 2, Number 2, 1999, pages 18-22.
Imagine a damp morning during Christmas season in London. The city awakes to see streets swirling with a thick, gray mist. But this is no ordinary London fog. As the clouds roll through the streets and seep into the houses, men, women, and children are gasping for breath. Within hours, hospital emergency rooms are crammed with people complaining of stinging lungs. When the fog finally lifts 5 days later, thousands are dead.
It sounds incredible doesn't it? A dooms-day scenario dreamt up by a Hollywood writer, and something that - we hope - never could happen. But, it already did, in 1952. In fact, that scene was simply the worst of the so-called "killer fogs" or "pea-soupers" that repeatedly struck London, Liverpool, and other areas of England and Wales after World War II. They were caused when warm masses of air trapped smoke and fumes, primarily generated by coal heating. The1952 fog, which killed more than 4,000 people and contributed to the subsequent deaths of another 8,000, ultimately prompted the British Parliament to pass the Clean Air Act in 1956.
If the killer fog of the winter of 1952 was an environmental "wake-up" call for Britain and the West, perhaps the burning of the Indonesian rain forests in1997 and 1998 will prove to be the alarm that awakens the developing world to the importance of environmental conservation. Literally hundreds of blazes across the sprawling nation of islands contributed to a choking smoke haze that blanketed parts of Southeast Asia. The health and safety of millions of people in Indonesia, Singapore, Malaysia, Brunei, southern Thailand, and parts of the Philippines were threatened by the consequences of slash-and-burn fires aimed at clearing land.
That disaster put the dilemma of the developing world into stark relief. If you have been to Beijing, Bangkok, or Mexico City recently, you know how bad air quality can get. Visibility is so poor that some days it's hard to see across the street. More importantly, public health is endangered. Like Londoners in the early 1950's, thousands of people today are dying prematurely, and the health and productivity of countless others are impaired.
Now imagine these cities with more automobiles and with each person using more and more energy. This is precisely what will happen as a result of rising income levels and urbanization. The world now has almost 6 billion people. Two billion more will be added by 2025. Primary energy usage is likely to grow by more than 50% by that time as the children of the billions of people now without commercial energy services are added to electricity grids and acquire automobiles, trucks, or motorcycles.
Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease
Authors: Bourgognon Julie-Myrtille , Spiers Jereme G. , Robinson Sue , Scheiblich Hannah , Ortori Catharine , Bradley Sophie J. , Tobin Andrew B. , Steinert Joern 
Published: April 2020

Abstract
Background: Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s, Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated post-translational modifications impact upon protein functions that can exacerbate pathology. Non-enzymatic and irreversible glycation signalling has been implicated as an underlying pathway that promotes protein misfolding, but the direct interactions between both pathways are poorly understood. Methods: Here we investigated the potential therapeutic effects of supressing neurotoxic NO signalling during early progression of prion disease. Tg37 mice aged 3-4 weeks were inoculated by intracerebral injection with either 1% brain homogenate of Rocky Mountain Laboratory (RML) scrapie prion protein or control normal brain homogenate (NBH). Hippocampal gene and protein expression levels of oxidative and nitrergic stress markers were analysed and electrophysiological characterisations of pyramidal neurons were performed in 6-10 weeks old RML and NBH mice. Mice were injected with a NO synthase (NOS) inhibitor and the time course of disease markers was compared to controls. Electrophysiology, immunoblotting and immunocytochemistry studies were performed to identify the effects of NOS inhibition on neurophysiology, glycation, prion protein misfolding and cell death. Statistical analyses employed two-tailed unpaired Student’s t-test, one-way or two-way ANOVA as required and data were considered significant with P<0.05.Results: Increased neuroinflammatory signalling was observed in mice between 6 and 10 weeks post inoculation (w.p.i.) with scrapie prion protein which was characterised by enhanced nitrergic stress and associated with a decline in hippocampal neuronal function by 9 w.p.i.. Daily in vivo administration of the NOS inhibitor L-NAME between 6 and 9 w.p.i. at 20 mg/kg abolished the functional degeneration of hippocampal neurons in prion mice. We further found that this intervention in diseased mice ameliorated 3-nitrotyrosination of triose-phosphate isomerase, an enzyme involved in the formation of disease-associated glycation signalling. Furthermore, L-NAME application reduced the expression of the receptor for advanced glycation end products and the accumulation of hippocampal prion misfolding. Conclusions: Our data suggest that alleviating nitrergic stress during early phases of neurodegeneration reduces neurotoxic post-translational NO signalling and glycation-assisted prion misfolding in the hippocampus, a mechanism which might be applicable to other protein misfolding neurodegenerative conditions.
Can diet change the diversity of ruminal bacterial species in beef cattle?
Authors: Melo Hilda Silva Araujo de , Ítavo Luis Carlos Vinhas , Castro Alinne Pereira de , Ítavo Camila Celeste Brandão Ferreira , Dias Alexandre Menezes , Difante Gelson dos Santos , Santos Geraldo Tadeu dos , Niwa Marcus Vinicius Garcia , Moraes Gabriella Jorgetti de , Wanderley Alysson Martins , Gurgel Antonio Leandro Chaves , Mateus Rodrigo Gonçalves , Benchaar Chaouki 
Published: April 2020

Abstract
Background

The objective of this study was to assess the effects of diet on bacterial species in the solid fraction of the ruminal content using the gene sequences of the conserved 16S rDNA region steers fed one of the following diets: canola (C), cottonseed (A), sunflower (G), soybean (SO), corn silage (S) and control diet (PD). Canola, cottonseed, sunflower and soybean were fed as whole seeds. Six crossbred steers (Body weight = 416.33 ± 93.30 kg; mean ± SD), castrated male, and fitted with ruminal cannula were used. The experimental design was a 6 × 6 Latin square design.

Results

Cellulolytic bacteria were predominant for all diets, with 47.75% of Operational Taxonomic Units (OTU) in animals fed the cottonseed diet. Amylolytic bacteria were identified for all diets, representing 62.51% OTU in animals consuming the sunflower diet. Proteolytic bacteria were identified for all diets, corresponding to 65.96% OUT in animals fed the sunflower diet. Lactic bacteria were identified for all diets. Megasphaera elsdenii bacterium was identified for all diets, with a greater diversity of this bacterium in steers fed the control diet. This bacterium may reduce the availability of hydrogen in the rumen due to propionate production and lactate utilization.

Conclusion

Oilseed in the diet showed a similarity of bacteria species with 47.5% of changing of the ruminal flora.
Silencing of Tenascin-C inhibits hypoxia reoxygenation injury of cardiomyocyte through TLR4和NF-κB pathway
Authors: Ge Zhiru , Zhang Chenjun , Lin Jie , Pan Hong , Lin Zijun , Zhang Wei 
Published: April 2020

Abstract
Background: Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide, and its main pathophysiological mechanism is myocardial ischemia/reperfusion (I/R) injury. TNC is an extracellular matrix glycoprotein, and high TNC expression was associated with MI and ventricular remodeling. The present study aimed to investigate the effect and the underlying mechanisms of TNC on myocardial I/R injury.Methods: Cardiomyocyte H9c2 cells was used to establish an in vitro hypoxia/reoxygenation (H/R) model, which were under hypoxia for 4 h and reoxygenation for 12 h. TNC was silenced by small interfering RNA (siRNA) in H9c2 cells.Results: TNC mRNA and protein expressions were increased by H/R. TNC knockdown by siRNA improved the cell viability in H/R-stimulated H9c2 cells. TNC knockdown reversed the H/R-induced increase in the apoptosis, as evidenced by reduced TUNEL+ cells and caspase-3 activity, and inhibited oxidative stress and inflammatory cytokine production. TNC silencing inhibits TLR4 mRNA and protein expressions and NF-kappa B signals, as evidenced by reduced nuclear NF-κB p65 and increased cytoplasmic I-κBα in H/R-stimulated H9c2 cells. All these cardioprotection against H/R by siTNC was reversed by TLR4 overexpression.Conclusions: TNC silencing prevents H/R-induced injury by inhibiting apoptosis and oxidative stress by inhibition of TLR4-NF-κB pathway.