bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le vice de l’alcool et les discours antialcooliques au tournant du XXe siècle québécois*
Authors: Robert Caroline 
Published: August 2020

Le développement de nouvelles théories sociales et médicales au tournant du XXe siècle a permis de reformuler les discours sur l’alcoolisme. Ce présent article se penche sur l’intégration de ces nouveaux savoirs par les groupes de tempérance québécois, entre 1870 et 1921. Plus qu’un manque de volonté, la consommation abusive d’alcool devient le marqueur d’une défaillance sociale menaçant l’avenir de la nation. Les figures du pauvre, de la mauvaise mère et de la famille dysfonctionnelle sont présentées comme les principales manifestations de ce désordre qu’entraîne l’intempérance.
Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs
Authors: Zhao Na , Song Xiangrong , Naito Hisao , Li Hongling , Huang Yongshun , Liu Lili , Lu Fengrong , Cai Tingfeng , Ito Yuki , Kamijima Michihiro , Huang Hanlin , Nakajima Tamie , Wang Hailan 
Published: August 2020

Abstract

Objectives
Occupational exposure to trichloroethylene (TCE) induces trichloroethylene hypersensitivity syndrome (TCEHS), which causes hypersensitivity dermatitis and hepatitis. However, whether TCE itself or its two metabolites, trichloroethanol (TCEOH) and trichloroacetic acid (TCA), are involved in TCEHS remains unclear. Therefore, in this study we explored the allergens causing TCEHS and characterized TCEHS-related liver injury in guinea pigs.

Method
The guinea pig maximization test was performed using TCE, TCEOH, and TCA as candidate allergens. Skin inflammation was scored, and liver function and histopathological changes were evaluated by biochemical tests and hematoxylin and eosin staining, respectively.

Results
The sensitization rates for TCE, TCEOH, and TCA were 90.0%, 50.0%, and 0.0%, respectively. In the TCE and TCEOH experimental groups, the skin showed varying degrees of erythema with eosinophil granulocyte infiltration in the dermis. Additionally, serum alanine aminotransferase and γ-glutamyl transpeptidase levels increased significantly, and histological analysis revealed focal hepatocellular necrosis with inflammatory cell infiltration in the liver.

Conclusions
TCE is the main cause of allergy and TCEOH is a secondary factor for allergy in guinea pigs. TCE and TCEOH can cause immune-mediated skin sensitization complicated by focal hepatic necrosis.
miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR‐186‐5p as a potential antiretroviral factor in macrophages
Authors: Zhao Zezhou , Muth Dillon C. , Mulka Kathleen , Liao Zhaohao , Powell Bonita H. , Hancock Grace V. , Metcalf Pate Kelly A. , Witwer Kenneth W. 
Published: August 2020

Cervicovaginal secretions, or their components collected, are referred to as cervicovaginal lavage (CVL). CVL constituents have utility as biomarkers and play protective roles in wound healing and against HIV‐1 infection. However, several components of cervicovaginal fluids are less well understood, such as extracellular RNAs and their carriers, for example, extracellular vesicles (EVs). EVs comprise a wide array of double‐leaflet membrane extracellular particles and range in diameter from 30 nm to over one micron. The aim of this study was to determine whether differentially regulated CVL microRNAs (miRNAs) might influence retrovirus replication. To this end, we characterized EVs and miRNAs of primate CVL during the menstrual cycle and simian immunodeficiency virus (SIV) infection of macaques. EVs were enriched by stepped ultracentrifugation, and miRNA profiles were assessed with a medium‐throughput stem‐loop/hydrolysis probe qPCR platform. Whereas hormone cycling was abnormal in infected subjects, EV concentration correlated with progesterone concentration in uninfected subjects. miRNAs were present predominantly in the EV‐depleted CVL supernatant. Only a small number of CVL miRNAs changed during the menstrual cycle or SIV infection, for example, miR‐186‐5p, which was depleted in retroviral infection. This miRNA inhibited HIV replication in infected macrophages in vitro. In silico target prediction and pathway enrichment analyses shed light on the probable functions of miR‐186‐5p in hindering HIV infections via immunoregulation, T‐cell regulation, disruption of viral pathways, etc. These results provide further evidence for the potential of EVs and small RNAs as biomarkers or effectors of disease processes in the reproductive tract.
Tracing enhances problem‐solving transfer, but without effects on intrinsic or extraneous cognitive load
Authors: Ginns Paul , Hu Fang‐Tzu , Bobis Janette 
Published: August 2020

SummaryPeople can make pointing gestures and tracing actions with the index finger with little or no conscious effort. From the perspective of cognitive load theory, such “biologically primary” gestures and actions might help people learn “biologically secondary” concepts and skills requiring extended cognitive effort, such as reading, science, or mathematics. Studies on tracing or tracing and pointing have yielded mixed findings regarding hypothesized effects on intrinsic and extraneous cognitive load. The present study investigated whether computer‐based instructions to trace elements of worked examples on angle relationships would affect school students' (N = 106) self‐reports of intrinsic and extraneous cognitive load, as well as problem‐solving transfer test performance. The tracing effect on transfer posttests seen in prior studies was replicated, but cognitive load hypotheses were not supported. Implications for educational practice and future research are discussed.
Presence of administrators differentially impacts eyewitness discriminability for same‐ and other‐race identifications
Authors: Rothweiler Jesse N. , Goodwin Kerri A. , Kukucka Jeff 
Published: August 2020

SummaryBest practice guidelines recommend that eyewitness lineup administrators be blind to a suspect's identity, but no research has investigated whether the mere presence of a lineup administrator impacts eyewitness identification decisions. Informed by social facilitation theory, we predicted that the presence of an audience would differentially impact identification accuracy for same‐ and other‐race identifications. Participants (N = 191) viewed same‐ and other‐race lineups either with an audience or alone. Although the presence of an audience did not directly impact identification accuracy, significant indirect effects indicated that the audience provoked evaluation apprehension which hindered other‐race identification accuracy and improved same‐race identification accuracy. We suggest that using double‐blind lineup procedures may not sufficiently protect eyewitness identification accuracy when making other‐race lineup decisions in the presence of others.
The psychology of confessions: A comparison of expert and lay opinions
Authors: Alceste Fabiana , J. Luke Timothy , D. Redlich Allison , Hellgren Johanna , D. Amrom Aria , M. Kassin Saul 
Published: August 2020

SummaryDespite a body of confessions research that is generally accepted in the scientific community, courts often exclude experts on the ground that such testimony would not assist the jury, which can use its common sense. To examine whether laypeople know the contents of expert testimony on confessions, we asked 151 lay participants to indicate their beliefs about 30 confession‐related statements used in a recent survey of 87 confession experts (Kassin et al., American Psychologist, 2018, 73, 63–80). Participants agreed with experts on only 10 of the 30 propositions, suggesting that much of the psychology of confessions is not common knowledge and that expert testimony can assist the trier of fact.
Systematic Review of the Evolution of Health‐Economic Evaluation Models of Osteoarthritis
Authors: Zhao Ting , Ahmad Hasnat , de Graaff Barbara , Xia Qing , Winzenberg Tania , Aitken Dawn , Palmer Andrew J. 
Published: August 2020

ObjectiveTo comprehensively synthesize the evolution of health‐economic evaluation models (HEEMs) of all osteoarthritis (OA) interventions, including preventions, core treatments, adjunct nonpharmacologic interventions, pharmacologic interventions, and surgical treatments.MethodsThe literature was searched within health‐economic/biomedical databases. Data extracted included OA type, population characteristics, model setting/type/events, study perspective, and comparators; the reporting quality of the studies was also assessed. The review protocol was registered at the International Prospective Register of Systematic Reviews (CRD42018092937).ResultsEighty‐eight studies were included. Pharmacologic and surgical interventions were the focus in 51% and 44% of studies, respectively. Twenty‐four studies adopted a societal perspective (with increasing popularity after 2013), but most (63%) did not include indirect costs. Quality‐adjusted life years was the most popular outcome measure since 2008. Markov models were used by 62% of studies, with increasing popularity since 2008. Until 2010, most studies used short‐to‐medium time horizons; subsequently, a lifetime horizon became popular. A total of 86% of studies reported discount rates (predominantly between 3% and 5%). Studies published after 2002 had a better coverage of OA‐related adverse events (AEs). Reporting quality significantly improved after 2001.ConclusionOA HEEMs have evolved and improved substantially over time, with the focus shifting from short‐to‐medium‐term pharmacologic decision‐tree models to surgical‐focused lifetime Markov models. Indirect costs of OA are frequently not considered, despite using a societal perspective. There was a lack of reporting sensitivity of model outcome to input parameters, including discount rate, OA definition, and population parameters. While the coverage of OA‐related AEs has improved over time, it is still not comprehensive.
Physical and Psychosocial Burden of Psoriatic Arthritis: Longitudinal Data From a Population‐Based Study in Norway
Authors: Haugeberg Glenn , Lund Nilsen Tom Ivar , Kavanaugh Arthur , Thomsen Ruth Stoklund , Gulati Agnete Malm , Hoff Mari 
Published: August 2020

ObjectivePsoriatic arthritis (PsA) can have a significant impact on health‐related quality of life (HRQoL). Data on the timing of changes in the HRQoL of patients with PsA are limited. The present study was undertaken to explore associations between sleep disturbance, fatigue, pain, anxiety, depression, general health status, and satisfaction with life before and after a diagnosis of PsA compared to the general population.MethodsPatients diagnosed with PsA between the Nord‐Trøndelag Health Study (HUNT2 [1995–1997] and HUNT3 [2006–2008]) surveys were compared to the general population. The adjusted odds ratio (ORadj) with 95% confidence interval (95% CI) was estimated at both time points.ResultsAmong 36,507 individuals participating in both the HUNT2 and HUNT3 surveys, 160 were diagnosed with PsA between the surveys. The prevalence of sleep disturbances and fatigue was higher in PsA patients after diagnosis compared to the general population (ORadj 2.24 [95% CI 1.55–3.25] and ORadj 1.94 [95% CI 1.27–2.98], respectively). The prevalence of pain and poor health status were higher in patients with PsA compared with the general population even before PsA was diagnosed (ORadj 2.81 [95% CI 1.96–4.02] and ORadj 3.08 [95% CI 2.19–4.35], respectively) and increased after diagnosis of PsA (ORadj 12.87 [95% CI 6.27–26.40] and ORadj 5.63 [95% CI 3.99–7.95], respectively). For anxiety, depression, and life satisfaction, patients who developed PsA were comparable to the general population both before and after the diagnosis of PsA.ConclusionCompared to the general population, PsA patients reported a higher prevalence of pain and poorer health status before diagnosis. Increased prevalence of sleep disturbances and fatigue in PsA patients was only found after the PsA diagnosis, and no differences between patients with PsA and the control group were found for anxiety and depression.
Variation in Treatment of Children Hospitalized With New‐Onset Systemic Juvenile Idiopathic Arthritis in the US
Authors: Peterson Rosemary G. , Xiao Rui , James Karen E. , Katcoff Hannah , Fisher Brian T. , Weiss Pamela F. 
Published: August 2020

ObjectiveIncreasing evidence supports the conclusion that early initiation of biologics may dramatically improve disease course and reduce glucocorticoid exposure for children with systemic juvenile idiopathic arthritis (JIA). The present study was undertaken to characterize variation in the use of first‐line biologic and glucocorticoid therapy and to identify drivers of variation in children hospitalized with new‐onset systemic JIA.MethodsWe conducted a retrospective cohort study of children hospitalized with new‐onset systemic JIA from 2008 to 2019 utilizing a comparative pediatric database from 52 tertiary care children’s hospitals. Subjects and treatment receipt were identified using International Classification of Diseases, Ninth Revision (ICD‐9) and ICD‐10 discharge diagnosis codes, pharmacy billing data, and clinical transaction classification codes. Mixed‐effects logistic regression was used to identify patient‐ and hospital‐level factors associated with receipt of glucocorticoids and biologics.ResultsIn total, 534 children with new‐onset systemic JIA hospitalized during the study period met inclusion criteria. Twenty‐nine percent received biologics, and 58% received glucocorticoids. Biologic use increased over time (P < 0.001), methotrexate use decreased (P < 0.01), and glucocorticoid use remained unchanged. Biologics and glucocorticoid use varied significantly between hospitals. High annual hospital volume, intensive care unit stay, and later discharge year were significantly associated with biologic exposure. Medium‐high and high annual hospital volume were significantly associated with less glucocorticoid exposure.ConclusionDespite increasing evidence demonstrating improved outcomes with first‐line treatment with biologics, we found significant treatment variation across hospitals with many children not receiving biologics and a persistent high rate of glucocorticoid exposure. These results underscore the need for comparative efficacy studies and improved treatment standardization.
How Foot Progression Angle Affects Knee Adduction Moment and Angular Impulse in Patients With and Without Medial Knee Osteoarthritis: A Meta‐Analysis
Authors: Wang Sizhong , Mo Shiwei , Chung Raymond C. K. , Shull Peter B. , Ribeiro Daniel C. , Cheung Roy T. H. 
Published: August 2020

ObjectiveTo investigate effects of foot progression angle (FPA) modification on the first and second peaks of external knee adduction moment (EKAM) and knee adduction angular impulse (KAAI) in individuals with and without medial knee osteoarthritis (OA) during level walking.MethodsPubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and SPORTDiscus were searched from inception to February 2020 by 2 independent reviewers. Included studies compared FPA modification (toe‐in or toe‐out gait) interventions to lower EKAM and/or KAAI with natural walking. Studies were required to report the first or second peaks of EKAM or KAAI.ResultsSixteen studies were included, and >85% of included patients were graded with Kellgren/Lawrence grade II–IV knee OA. Toe‐in gait reduced the first EKAM peak (standardized mean difference [SMD] –0.75 [95% confidence interval (95% CI) –1.05, –0.45]) and KAAI (SMD –0.46 [95% CI –0.86, –0.07]), while toe‐out gait reduced the second EKAM peak (SMD –1.04 [95% CI –1.34, –0.75]) in healthy individuals. For patients with knee OA, toe‐out gait reduced the second EKAM peak (SMD –0.53 [95% CI –0.75, –0.31]) and KAAI (SMD –0.26 [95% CI –0.49, –0.03]), while toe‐in gait did not affect both EKAM peaks and KAAI.ConclusionDiscrepancy in biomechanical effects of FPA modification was demonstrated between individuals with and without medial knee OA. Compared with natural walking, both toe‐in and toe‐out gait may be more effective in lowering EKAM and KAAI in healthy individuals. Toe‐out gait may reduce EKAM and KAAI in patients with mild‐to‐severe knee OA. There is insufficient data from patients with early‐stage knee OA, indicating that future research is required.
Impact of Disease Activity on Physical Activity in Patients With Psoriatic Arthritis
Authors: Hernández‐Hernández María Vanesa , Sánchez‐Pérez Hiurma , Luna‐Gómez Cristina , Ferraz‐Amaro Iván , Díaz‐González Federico 
Published: August 2020

ObjectiveThe purpose of this study was to compare physical activity (PA) in a group of patients with psoriatic arthritis (PsA) versus healthy controls and to determine whether the mobility of these patients is affected by disease activity.MethodsA group of 52 patients with PsA and 53 controls were included in this case–control study. PA was assessed by accelerometry in both groups and additionally with the International Physical Activity Questionnaire (IPAQ) in patients with PsA. Multiple regression analysis was used to compare PA between groups and to determine the relationship between PA and PsA features, including disease activity, as assessed by the 28‐joint Disease Activity Score (DAS28) and the Disease Activity Index for Psoriatic Arthritis (DAPSA) score. In a group of 36 patients, a test–retest study was carried out after 6 months.ResultsThe time engaged in moderate‐to‐vigorous physical activity (MVPA) per day, as evaluated by accelerometry, and adjusted by confounders, proved similar in patients with PsA and controls. In patients with PsA, disease activity was inversely related to PA as assessed either by IPAQ or accelerometry. When PA was compared in patients with PsA between the 2 visits, a significant difference in the amount of time doing MVPA was found (42 ± 33 versus 30 ± 22 minutes/day; P = 0.004). Interestingly, in the test–retest study, variations in disease activity over time based on DAPSA scores (r = –0.49, P = 0.002) and DAS28 using the C‐reactive protein level (r = –0.4, P = 0.017) were inversely correlated with changes in PA, as determined by accelerometry.ConclusionPatients with PsA show levels of PA like healthy controls. In patients with PsA, disease activity and PA are inversely correlated and the evaluation of PA by accelerometry is sensitive to changes in disease activity.
Thermal Conductive 2D Boron Nitride for High‐Performance All‐Solid‐State Lithium–Sulfur Batteries
Authors: Yin Xuesong , Wang Liu , Kim Yeongae , Ding Ning , Kong Junhua , Safanama Dorsasadat , Zheng Yun , Xu Jianwei , Repaka Durga Venkata Maheswar , Hippalgaonkar Kedar , Lee Seok Woo , Adams Stefan , Zheng Guangyuan Wesley 
Published: August 2020

AbstractPolymer‐based solid‐state electrolytes are shown to be highly promising for realizing low‐cost, high‐capacity, and safe Li batteries. One major challenge for polymer solid‐state batteries is the relatively high operating temperature (60–80 °C), which means operating such batteries will require significant ramp up time due to heating. On the other hand, as polymer electrolytes are poor thermal conductors, thermal variation across the polymer electrolyte can lead to nonuniformity in ionic conductivity. This can be highly detrimental to lithium deposition and may result in dendrite formation. Here, a polyethylene oxide‐based electrolyte with improved thermal responses is developed by incorporating 2D boron nitride (BN) nanoflakes. The results show that the BN additive also enhances ionic and mechanical properties of the electrolyte. More uniform Li stripping/deposition and reversible cathode reactions are achieved, which in turn enable all‐solid‐state lithium–sulfur cells with superior performances.
Robot‐assisted minimally invasive esophagectomy for esophageal cancer: Meticulous surgery minimizing postoperative complications
Authors: Hosoda Kei , Niihara Masahiro , Harada Hiroki , Yamashita Keishi , Hiki Naoki 
Published: August 2020

AbstractMinimally invasive esophagectomy (MIE) has been reported to reduce postoperative complications especially pulmonary complications and have equivalent long‐term survival outcomes as compared to open esophagectomy. Robot‐assisted minimally invasive esophagectomy (RAMIE) using da Vinci surgical system (Intuitive Surgical, Sunnyvale, USA) is rapidly gaining attention because it helps surgeons to perform meticulous surgical procedures. McKeown RAMIE has been preferably performed in East Asia where squamous cell carcinoma which lies in more proximal esophagus than adenocarcinoma is a predominant histological type of esophageal cancer. On the other hand, Ivor Lewis RAMIE has been preferably performed in the Western countries where adenocarcinoma including Barrett esophageal cancer is the most frequent histology. Average rates of postoperative complications have been reported to be lower in Ivor Lewis RAMIE than those in McKeown RAMIE. Ivor Lewis RAMIE may get more attention for thoracic esophageal cancer. The studies comparing RAMIE and MIE where recurrent nerve lymphadenectomy was thoroughly performed reported that the rate of recurrent nerve injury is lower in RAMIE than in MIE. Recurrent nerve injury leads to serious complications such as aspiration pneumonia. It seems highly probable that RAMIE is beneficial in performing recurrent nerve lymphadenectomy. Surgery for esophageal cancer will probably be more centralized in hospitals with surgical robots, which enable accurate lymph node dissection with less complications, leading to improved outcomes for patients with esophageal cancer. RAMIE might occupy an important position in surgery for esophageal cancer.
Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline
Authors: Buckley Rachel F. , Scott Matthew R. , Jacobs Heidi I. L. , Schultz Aaron P. , Properzi Michael J. , Amariglio Rebecca E. , Hohman Timothy J. , Mayblyum Danielle V. , Rubinstein Zoe B. , Manning Lyssa , Hanseeuw Bernard J. , Mormino Elizabeth C. , Rentz Dorene M. , Johnson Keith A. , Sperling Reisa A. 
Published: August 2020

ObjectiveThe goal of this study was to examine sex differences in tau distribution across the brain of older adults, using positron emission tomography (PET), and investigate how these differences might associate with cognitive trajectories.MethodsParticipants were 343 clinically normal individuals (women, 58%; 73.8 [8.5] years) and 55 individuals with mild cognitive impairment (MCI; women, 38%; 76.9 [7.3] years) from the Harvard Aging Brain Study and the Alzheimer's Disease Neuroimaging Initiative. We examined 18F‐Flortaucipir (FTP)‐positron emission tomography (PET) signal across 41 cortical and subcortical regions of interest (ROIs). Linear regression models estimated the effect of sex on FTP‐signal for each ROI after adjusting for age and cohort. We also examined interactions between sex*Aβ‐PET positive / negative (+ / −) and sex*apolipoprotein ε4 (APOEε4) status. Linear mixed models estimated the moderating effect of sex on the relationship between a composite of sex‐differentiated tau ROIs and cognitive decline.ResultsWomen showed significantly higher FTP‐signals than men across multiple regions of the cortical mantle (p < 0.007). β‐amyloid (Aβ)‐moderated sex differences in tau signal were localized to medial and inferio‐lateral temporal regions (p < 0.007); Aβ + women exhibited greater FTP‐signal than other groups. APOEε4‐moderated sex differences in FTP‐signal were only found in the lateral occipital lobe. Women with higher FTP‐signals in composite ROI exhibited faster cognitive decline than men (p = 0.04).InterpretationTau vulnerability in women is not just limited to the medial temporal lobe and significantly contributed to greater risk of faster cognitive decline. Interactive effects of sex and Aβ were predominantly localized in the temporal lobe, however, sex differences in extra‐temporal tau highlights the possibility of accelerated tau proliferation in women with the onset of clinical symptomatology. ANN NEUROL 2020;88:921–932