bluuebunny/crossref_metadata_2025_split huggingface dataset:
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus
Authors: Mackel Joseph J. , Garth Jaleesa M. , Blackburn Jonathan P. , Jones MaryJane , Steele Chad 
Published: February 2020

Abstract
Development of invasive aspergillosis correlates with impairments in innate immunity. We and others have recently shown that arachidonic acid metabolism pathways, specifically the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) pathways, participate in the induction of protective innate immune responses during invasive aspergillosis. Based on the high degree of cooperation and interconnection within the eicosanoid network, we hypothesized that 12/15-LOX is also active during invasive aspergillosis. We report in this study that mice deficient in the gene encoding 12/15-LOX (Alox15) are profoundly susceptible to invasive aspergillosis. Decreased survival correlated with increased fungal burden and evidence of increased lung damage. These defects were associated with very early (6 and 12 h) 12/15-LOX–dependent inflammatory cytokine (IL-1α, IL-1β, and TNF-α) and chemokine (CCL3 and CCL4) production. Neutrophil levels in the lung were blunted in the absence of 12/15-LOX, although neutrophil antifungal activity was intact. However, lower neutrophil levels in the lungs of Alox15−/− mice were not a result of impaired recruitment or survival; rather, Alox15−/− mice demonstrated impaired neutrophil granulopoiesis in the bone marrow intrinsically and after fungal exposure. Employing a lower inoculum to allow for better survival allowed the identification of 12/15-LOX–dependent induction of IL-17A and IL-22. Impaired IL-17A and IL-22 production correlated with reduced invariant NKT cell numbers as well as lower IL-23 levels. Together, these data indicate that 12/15-LOX is a critical player in induction of the earliest aspects of the innate immune response to Aspergillus fumigatus.
Flexible and Self‐Powered Lateral Photodetector Based on Inorganic Perovskite CsPbI3–CsPbBr3 Heterojunction Nanowire Array
Authors: Wang Meng , Tian Wei , Cao Fengren , Wang Min , Li Liang 
Published: February 2020

AbstractSelf‐powered perovskite photodetectors mainly adopt the vertical heterojunction structure composed of active layer, electron–hole transfer layers, and electrodes, which results in the loss of incident light and interfacial accumulation of defects. To address these issues, a self‐powered lateral photodetector based on CsPbI3–CsPbBr3 heterojunction nanowire arrays is designed on both a rigid glass and a flexible polyethylene naphthalate substrate using an in situ conversion and mask‐assisted electrode fabrication method. Through adding the polyvinyl pyrrolidone and optimizing the concentration of precursors under the pressure‐assisted moulding process, both the crystallinity and stability of perovskite nanowire array are improved. The nanowire array–based lateral device shows a high responsivity of 125 mA W−1 and a fast rise and decay time of 0.7 and 0.8 ms under a self‐powered operation condition. This work provides a new strategy to fabricate perovskite heterojunction nanoarrays towards self‐powered photodetection.
Unprecedented Improvement of Single Li‐Ion Conductive Solid Polymer Electrolyte Through Salt Additive
Authors: Martinez‐Ibañez Maria , Sanchez‐Diez Eduardo , Qiao Lixin , Zhang Yan , Judez Xabier , Santiago Alexander , Aldalur Itziar , Carrasco Javier , Zhu Haijin , Forsyth Maria , Armand Michel , Zhang Heng 
Published: February 2020

AbstractSolid‐state lithium metal (Li°) batteries (SSLMBs) are believed to be the most promising technologies to tackle the safety concerns and the insufficient energy density encountered in conventional Li‐ion batteries. Solid polymer electrolytes (SPEs) inherently own good processability and flexibility, enabling large‐scale preparation of SSLMBs. To minimize the growth of Li° dendrites and cell polarization in SPE‐based SSLMBs, an additive‐containing single Li‐ion conductive SPE is reported. The characterization results show that a small dose of electrolyte additive (2 wt%) substantially increases the ionic conductivity of single Li‐ion conductive SPEs as well as the interfacial compatibility between electrode and SPE, allowing the cycling of SPE‐based cells with good electrochemical performance. This work may provide a paradigm shift on the design of highly cationic conductive electrolytes, which are essential for developing safe and high‐performance rechargeable batteries.
Large‐Range, Reversible Directional Spreading of Droplet on a Double‐Gradient Wrinkled Surface Adjusted Under Mechanical Strain
Authors: Chai Hao , Tian Ye , Yu Sihang , Cao Binbin , Peng Xiang , Zhang Zheng , Liu Aiping , Wu Huaping 
Published: February 2020

AbstractDynamical regulation to unidirectional wetting has received considerable attention in recent years due to its important role in flexible electronics, microfluidics, drug transportation, and so forth. It is of great significance to prepare a surface which allows the droplet to spread directionally on it with the length of droplet reversibly fluctuated within a broad range under external stimulation. In this paper, a double‐gradient wrinkled structure is prepared by constructing the structure‐gradient pillar arrays on a mechanics‐adjusted wrinkled surface and subsequently making chemical gradient by oxygen plasma treatment. Under the synergistic effect of the structural gradient, chemical gradient, and wrinkled structure, the droplet can undergo unidirectional spreading and realize dynamic regulation of the spreading length on the flexible structure. This will provide a propagable method for the regulation of surface wetting.
Ultrathin Membranes: A New Opportunity for Ultrafast and Efficient Separation
Authors: Gao Shoujian , Wang Dong , Fang Wangxi , Jin Jian 
Published: February 2020

AbstractDeveloping advanced membranes with both high permeance and selectivity to enable ultrafast and efficient separation is a persistent pursuit by materials scientists. In recent years, diverse ultrathin membranes with nanometer‐scale thickness and unique membrane structures have been developed. These materials show ultrahigh permeance and excellent selectivity in water desalination, dye rejection, oil–water purification, and gas separation applications. Herein, current state‐of‐the‐art ultrathin membranes are introduced, including polyamide membranes, diamond‐like carbon membranes, single‐walled carbon nanotube network membranes, metal hydroxide nanostrand network membranes, protein membranes, and graphene laminar membranes and their derivatives. The designs, fabrication techniques, and performance advantages of these ultrathin membranes are discussed. A summary of the remaining challenges and potential future directions are also presented.
Integrated Metasurfaces with Microprints and Helicity‐Multiplexed Holograms for Real‐Time Optical Encryption
Authors: Luo Xuhao , Hu Yueqiang , Li Xin , Jiang Yuting , Wang Yasi , Dai Peng , Liu Qing , Shu Zhiwen , Duan Huigao 
Published: February 2020

AbstractOptical encryption with multichannel, high complexity, and artistry characteristics has become one of the most significant approaches for modern information security. Recently emerged metasurface‐based optics consisting of planar subwavelength metamaterials has been engineered as an ideal platform for optical encryption because of its capability of manipulating various optical parameters and enhancing information storage capacity. However, limited encrypted channels and insufficient real‐time encryption abilities hinder its practical applications. A novel integrated metasurface is proposed, which can regulate the amplitude, phase, and polarization of light wave simultaneously to realize the combination of microprint and helicity‐multiplexed meta‐holography with negligible crosstalk. By encoding an online editable quick response code into the microprint as a keystore, an optical encryption device is demonstrated with 26‐1 storage capacity endowed by wavelength‐ and helicity‐dependent hologram images that can be employed in real time. The integration scheme enables multidimensional information storage and real‐time encryption and decryption capability, which provides an approachable way for the practical application of metasurface devices in the field of optical encryption.
Spin of the M87 Black Hole
Authors: Garofalo David 
Published: February 2020

AbstractSpin measurement of the 6.5 billion solar mass black hole in M87 from the Event Horizon Telescope image is the latest in a series that span a wide range in values, but that tend to share the feature of corotation between the accretion flow and black hole. The spin paradigm for black holes predicts very high black hole spin which in that framework is produced in its last significant merger. High black hole spin appears to be ruled out in the gap paradigm, however, which predicts early formation with a mass already in excess of 4 billion solar masses. In this picture, the black hole experiences slow evolution as it departs from its original radio quasar phase and over billions of years not only fails to double its mass but also falls short of regaining its original high spin, such that it is now compatible with a corotating accreting black hole whose dimensionless spin fits best in the range 0.2 < a < 0.5.
Grenzflächenpolymerisation: Von der Chemie zu funktionellen Materialien
Authors: Zhang Feilong , Fan Jun‐bing , Wang Shutao 
Published: February 2020

AbstractDie Grenzflächenpolymerisation, die eine chemische Reaktion auf die Flüssig‐Flüssig‐ oder Flüssig‐Luft‐Grenzfläche begrenzt, weist große Vorzüge für die kontrollierbare Herstellung von Filmen, Kapseln und Fasern als Trennmembran‐ und Elektrodenmaterialien auf. Jüngste Entwicklungen der Polymerchemie und deren Technologien verleihen der Grenzflächenpolymerisation neue Impulse. In diesem Aufsatz werden jüngste Entwicklungen der Grenzflächenpolymerisation im Zusammenhang verschiedener Polymerisationstypen betrachtet: Grenzflächenpolykondensation, Grenzflächenpolyaddition, oxidative Grenzflächenpolymerisation, Grenzflächenpolykoordination, supramolekulare Grenzflächenpolymerisation und einige andere. Die damit herstellbaren funktionellen Materialien werden beschrieben und ein Ausblick auf die Herausforderungen und Möglichkeiten gegeben, die neue Technologien für die Grenzflächenpolymerisation mit sich bringen. Es ist davon auszugehen, dass die Grenzflächenpolymerisation weiterhin faszinierende funktionelle Materialien hervorbringen wird.
Silver‐Triggered Activity of a Heterogeneous Palladium Catalyst in Oxidative Carbonylation Reactions
Authors: Li Man‐Bo , Yang Ying , Rafi Abdolrahim A. , Oschmann Michael , Grape Erik Svensson , Inge A. Ken , Córdova Armando , Bäckvall Jan‐E. 
Published: February 2020

AbstractA silver‐triggered heterogeneous Pd‐catalyzed oxidative carbonylation has been developed. This heterogeneous process exhibits high efficiency and good recyclability, and was utilized for the one‐pot construction of polycyclic compounds with multiple chiral centers. AgOTf was used to remove chloride ions in the heterogeneous catalyst Pd‐AmP‐CNC, thereby generating highly active PdII, which results in high efficiency of the heterogeneous catalytic system.
Stimuli‐Responsive Molecular Photon Upconversion
Authors: Yanai Nobuhiro , Kimizuka Nobuo 
Published: February 2020

AbstractThe addition of stimuli‐responsiveness to anti‐Stokes emission provides a unique platform for biosensing and chemosensing. Particularly, stimuli‐responsive photon upconversion based on triplet–triplet annihilation (TTA‐UC) is promising due to its occurrence at low excitation intensity with high efficiency. This Minireview summarizes the recent developments of TTA‐UC switching by external stimuli such as temperature, oxygen, chemicals, light, electric field, and mechanical force. For the systematic understanding of the underlying general mechanisms, the switching mechanisms are categorized into four types: 1) aggregation‐induced UC; 2) assembly‐induced air‐stable UC; 3) diffusion‐controlled UC; and 4) energy‐transfer‐controlled UC. The development of stimuli‐responsive smart TTA‐UC systems would enable sensing with unprecedented sensitivity and selectivity, and expand the scope of TTA‐UC photochemistry by combination with supramolecular chemistry, materials chemistry, mechanochemistry, and biochemistry.
Dysprosiacarboranes as Organometallic Single‐Molecule Magnets
Authors: Jin Peng‐Bo , Zhai Yuan‐Qi , Yu Ke‐Xin , Winpenny Richard E. P. , Zheng Yan‐Zhen 
Published: February 2020

AbstractThe dicarbollide ion, nido‐C2B9H112− is isoelectronic with cyclopentadienyl. Herein, we make dysprosiacarboranes, namely [(C2B9H11)2Ln(THF)2][Na(THF)5] (Ln=Dy, 1Dy) and [(THF)3(μ‐H)3Li]2[{η5‐C6H4(CH2)2C2B9H9}Dy{η2:η5‐C6H4(CH2)2C2B9H9}2Li] 3Dy and show that dicarbollide ligands impose strong magnetic axiality on the central DyIII ion. The effective energy barrier (Ueff) for the loss of magnetization can be varied by the substitution pattern on the dicarbollide. This finding is demonstrated by comparing complexes of nido‐C2B9H112− and nido‐[o‐xylylene‐C2B9H9]2−, which show a Ueff of 430(5) K and 804(7) K, respectively. The blocking temperature defined by the open hysteresis temperature of 3Dy reaches 6.8 K. Moreover, the linear complex [Dy(C2B9H11)2]− is predicted to have comparable properties with the linear [Dy(CpMe3)2]+ complex. As such, carboranyl ligands and their derivatives may provide a new type of organometallic ligand for high‐performance single‐molecule magnets.
Bis(imino)carbazolate: A Master Key for Barium Chemistry
Authors: Chapple Peter M. , Kahlal Samia , Cartron Julien , Roisnel Thierry , Dorcet Vincent , Cordier Marie , Saillard Jean‐Yves , Carpentier Jean‐François , Sarazin Yann 
Published: February 2020

AbstractReported here is a readily available bis(imino)carbazole‐based proligand that constitutes a convenient entry point into the challenging synthetic molecular chemistry of barium. It enables the preparation of rare or even, up to now, unknown, solution‐stable heteroleptic barium complexes. The syntheses and structural features for the first molecular barium fluoride and the first barium stannylide, with an unsupported Ba−Sn bond, are described, along with other carbazolate barium species: an amide (both a remarkably stable starting material and an excellent hydrophosphination precatalyst), iodide, and silanylide. DFT analysis of bonding patterns in the barium stannylide and barium silanylide highlights a prevailingly ionic barium–tetrelide bond with a small covalent contribution.
Clinicopathological significance of microRNA‐21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition
Authors: Watabe Shiori , Kikuchi Yoshinao , Morita Shigeki , Komura Daisuke , Numakura Satoe , Kumagai‐Togashi Arisa , Watanabe Masato , Matsutani Noriyuki , Kawamura Masafumi , Yasuda Masanori , Uozaki Hiroshi 
Published: February 2020

AbstractBackgroundPre‐resection pleural lavage cytology is useful to predict tumor recurrence and the prognosis of lung cancer patients. Recently, extracellular vesicles (EVs) isolated from effusion specimens have come under the spotlight, and several studies showed that microRNA in EVs is associated with prognosis. MicroRNA‐21 (miR‐21) is a representative onco‐microRNA, and miR‐21 in EVs (EV‐miR‐21) promotes cancer dissemination by inducing mesothelial to mesenchymal transition (MMT) in the peritoneal cavity. In this study, we isolated EVs from pleural lavage fluid and focused on EV‐miR‐21 as a diagnostic factor with a relationship to pleural dissemination.MethodsThe Cancer Genome Atlas dataset comprising of 448 cases of lung adenocarcinoma, tissue microarray of 144 cases of lung adenocarcinoma, and pleural lavage fluid of 41 cases was used to examine miR‐21 expression levels. The function of EV‐miR‐21 was investigated in vitro.ResultsThe miR‐21 expression level in primary sites was associated with a poor prognosis and correlated with pleural invasion of adenocarcinoma. EV‐miR‐21 levels in pleural lavage fluid were associated with positive cytology and pleural invasion in the primary sites, even in cytology‐negative cases. In vitro studies demonstrated that EV‐miR‐21 induces the MMT. Mesothelial cells in the MMT showed functions similar to cancer‐associated fibroblasts, which are an important stromal component in primary sites and disseminated pleural lesions.ConclusionsEV‐miR‐21 in pleural lavage fluid is important as a diagnostic and prognostic factor. Moreover, EV‐miR‐21 induces the MMT, which can form premetastatic niches of dissemination in the pleural cavity.
Master of Healthcare Administration program's journey to competency‐based education
Authors: Boykin Montrale , Duren‐Winfield Vanessa , Ohene Natasha M. , Steen Jessica 
Published: February 2020

AbstractWinston‐Salem State University's (WSSU), Master of Healthcare Administration (MHA) program, answered the call of the University of North Carolina system to offer education at an equal or higher quality than currently provided at a cost that is consistent with the state's constitution. As such, WSSU converted its MHA program to a competency‐based education (CBE) platform. The American College of Healthcare Executives (2017) states that this is an exciting time for healthcare management. The field requires talented people to help introduce and manage the changes taking place in health care. Implementation of the CBE program resulted in increased enrollment, increased student satisfaction through more flexibility to complete an advanced degree, and greater ease in balancing work–life student demands. WSSU's CBE program is designed to ensure that graduates have training and expertise they need to promote career readiness. This article will discuss the journey of transforming a hybrid MHA program to CBE.
Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3‐β/β‐catenin pathway
Authors: Wang Shoujie , Zhu Weifang 
Published: February 2020

Melanoma is a highly malignant and is a life‐threatening disease with no effective treatment currently. This study aims to evaluate the significance of TUSC3, an endoplasmic reticulum stress (ERS)‐inducible gene and explore its relationship with AKT/GSK3‐β/β‐catenin signalling pathway in melanoma cell WM451. We investigated TUSC3 expression in melanoma cell by qRT‐PCR, CCK‐8 and clonal formation assays were utilized to evaluate cell proliferation. Wound healing and transwell experiments detected cell migration and invasion. Flow cytometry detected the level of apoptosis. Western blot analysed MMP2, MMP9, p‐AKT, p‐GSK3‐β, β‐catenin and AKT, GSK3‐β, ERS‐related proteins and apoptosis‐related proteins in WM451 cells. The results revealed that TUSC3 was remarkably decreased in melanoma cell lines. Overexpression of TUSC3 significantly inhibits melanoma cell WM451 biological functions and promotes expression of ERS‐related proteins in WM451 cells, increases ERS in WM451 cells by inhibiting AKT/GSK3‐β/β‐catenin pathway. These finding suggest that TUSC3 regulates biological functions of melanoma cells WM451 and increases ERS in melanoma cells WM451 via the inhibition of the AKT/GSK3‐β/β‐catenin signalling pathway.Significance of the studyMelanoma is a highly malignant and is a life‐threatening disease with no effective treatment currently. Therefore, studying the molecular mechanism of melanoma occurrence and metastasis is essential for the treatment of melanoma. Meanwhile, mounting studies suggest that TUSC3 is considered to be closely associated with the development of various malignancies. TUSC3 regulates proliferation, migration and epithelial‐to‐mesenchymal transition, but the molecular mechanism of the tumour suppressor effects of TUSC3 on melanoma cells is not well understood. Our study demonstrates that TUSC3 inhibits biological function of melanoma cells and increases ERS in melanoma cells by inhibiting AKT/GSK3‐β/β‐catenin pathway. And this is expected to be a new target and method for the treatment of melanoma.
Binary Supramolecular Chirality “1/0” Switched by Hierarchical Photoisomerization of a Flower‐Like Compound with a Binaphthol Core and Alkyl‐Functionalized Azobenzene Side Chains
Authors: Hou Jiaxin , Liao Jinglun , Feng Yancong , Feringa Ben L. , Chen Jiawen , Li Hao , Zhou Guofu 
Published: February 2020

AbstractChiral supramolecular assemblies are abundant in nature, but controlling the chirality of artificial systems still remains a challenge. In this work, we developed a system where supramolecular chirality can be controlled between chiral and achiral states, namely a chiral “1/0” switch using a flower‐like azobenzene compound with a binaphthol core. Upon photoisomerization by ultraviolet irradiation, the terminal alkyl tails envelop the chiral “centre” with a reduction in the dihedral angle of the binaphthol moiety from 76.1° to 61.4°, like “closing petals”. In the doped liquid crystal E7 matrix, this hierarchical conformational transition prevents the transfer of chirality to the host liquid crystal, resulting in a degradation from cholesteric phase (HTP value: 13.84 μm−1) to an achiral nematic phase.
The influence of cognitive load on maternal postural sway and heart rate in response to infant vocalizations
Authors: Hiraoka Daiki , Nomura Michio 
Published: February 2020

AbstractInfants communicate their emotions to their caregivers through cries and laughter. Recent work suggests that adaptive parenting requires cognitive regulation of intuitive behaviors toward infants’ signals. In this study, we examined the effects of cognitive regulation on mothers’ unconscious behavioral and cardiac responses to infant cries and laughs. In all, 55 mothers took part in this study. To manipulate cognitive load, mothers were asked to memorize alphabet characters (two letters in the low cognitive load condition and eight in the high cognitive load condition). Then, they heard infant vocalizations (cries or laughs) for 6 s. During this time, we measured mothers’ behavioral (center of pressure, an index of approach–avoidance behavior) and physiological (heart rate) responses. Regardless of vocalization type (infant cries or laughs), high cognitive load increased mothers’ forward movement toward the infant sounds as well as mothers’ heart rate. These findings advance our understanding of the link between executive function and maternal response to infant signals by utilizing postural and physiological measures of maternal response during memory tasks that require cognitive resources.