bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying predictive biomarkers of CIMAvaxEGF success in Non–Small Cell Lung Cancer Patients
Authors: Lorenzo-Luaces Patricia , Sanchez Lizet , Saavedra Danay , Crombet Tania , Elst Wim Van der , Alonso Ariel , Molenberghs Geert , Lage Agustin 
Published: November 2019

Abstract
Background: Immunosenescence biomarkers and peripheral blood parameters are evaluated separately as possible predictive markers of immunotherapy. Here we illustrate the use of a causal inference model to identify predictive biomarkers of CIMAvaxEGF success in the treatment of Non–Small Cell Lung Cancer Patients.
Methods: Data from a clinical trial evaluating the effect on survival time of CIMAvax-EGF versus best supportive care were analyzed retrospectively following the causal inference approach. Pre-treatment potential predictive biomarkers included basal serum EGF concentration, peripheral blood parameters and immunosenescence biomarkers (The proportion of CD8 + CD28- T cells, CD4+ and CD8+ T cells, CD4/CD8 ratio and CD19+ B cells. The 33 patients with complete information were included. The predictive causal information (PCI) was calculated for all possible models. The model with a minimum number of predictors, but with high prediction accuracy (PCI>0.7) was selected. Good, rare and poor responder patients were identified using the predictive probability of treatment success.
Results: The mean of PCI increased from 0.486, when only one predictor is considered, to 0.98 using the multivariate approach with all predictors. The model considering the proportion of CD4+ T cell, basal EGF concentration, NLR, Monocytes, and Neutrophils as predictors were selected (PCI>0.74). Patients predicted as good responders according to the pre-treatment biomarkers values treated with CIMAvax-EGF had a significant higher observed survival compared with the control group (p=0.03). No difference was observed for bad responders.
Conclusions: Peripheral blood parameters and immunosenescence biomarkers together with basal EGF concentration in serum resulted in good predictors of the CIMAvax-EGF success in advanced NSCLC. The study illustrates the application of a new methodology, based on causal inference, to evaluate multivariate pre-treatment predictors.
Continuous intravenous infusion of remifentanil improves the experience of parturient undergoing repeated cesarean section under epidural anesthesia, a prospective, randomized study
Authors: yan wei , Xiong Yun , Yao Yu , Zhang Feng-jiang , Yu Li-an , Yan Min 
Published: November 2019

Abstract
Background: Unsatisfactory analgesia would occur frequently during repeated cesarean section under epidural anesthesia. The aim of this study is to observe the effects of intravenous remifentanil on maternal comfort, maternal and neonatal safety during repeated cesarean section under epidural anesthesia.Methods: A total of 80 parturients undergoing repeated cesarean section were involved in the study. The patients were randomly divided into the intravenous remifentanil- assisted epidural group (group R) and epidural group (group E), respectively (n=40). In group R, the remifentanil was continuously intravenously infused as an adjuvant to epidural anesthesia. In group E, 0.75% ropivacaine epidural or intravenous ketamine was administered as needed. Parturient baseline characteristics, vital signs, VAS scores, and comfort scores during surgery were recorded. Adverse effects were also recorded.Results: A total of 80 patients were enrolled in the current study and the final analyses included 39 patients in group R and 38 patients in group E. No differences in patients’ baseline characteristics were found between the two groups (p > 0.05). Compared with group E, the comfort score was significantly higher in group R (9.1±1.0 vs. 7.5±1.3, p<0.001), whereas the maximum VAS score was significantly lower in group R (1.8±1.2 vs. 4.1±1.0, p<0.001). Maternal and neonatal adverse effects did not differ between the two groups during surgery (p>0.05).Conclusions: Continuous intravenous infusion of low-dose remifentanil can significantly improve the experience of parturients undergoing repeated cesarean section under epidural anesthesia, without noticeable maternal or neonatal adverse effects.
Anais 10º CIRPACfoa - Círculo de Palestras à Comunidade 2018 FOA/UNESP
Authors: Faverani Leonardo Perez 
Published: November 2019

EditorialCaro(a) Leitor(a),O Círculo de Palestras à Comunidade da Faculdade de Odontologia do Campus de Araçatuba (CIRPACfoa) foi criado em 2009 pelo Departamento de Cirurgia e Clínica Integrada e apoiado pela direção da Faculdade de Odontologia de Araçatuba. Cadastrado inicialmente como o quarto objetivo do projeto de extensão “ATENDIMENTO CIRÚRGICO-ODONTOLÓGICO PARA PACIENTES COM TRAUMATISMO BUCO-MAXILO-FACIAL EM NÍVEL HOSPITALAR E AMBULATORIAL”, o CIRPACfoa foi sendo reconhecido pela Pró-reitoria de Extensão da UNESP, tornando-se um Círculo de ação independente do seu projeto de origem por possuir a prevenção como o seu principal objetivo. A necessidade crescente para que ocorra a prevenção dos traumas bucomaxilofaciais faz com que o projeto se torne uma ferramenta com grande potencial de inovação.Atualmente, o CIRPACfoa tornou-se um projeto anual e tem sido caracterizado pelo desenvolvimento de palestras que abordam os fatores etiológicos dos traumas bucomaxilofaciais, baseando-se em casos clínicos vivenciados pelo projeto de sua origem. Anualmente, o CIRPACfoa tem adequado o material didático da disciplina de Cirurgia e Traumatologia Bucomaxilofacial para a realização de palestras abordando temas como, Álcool, Acidentes Automobilísticos, Motociclísticos, Ciclísticos e Violência.Entre os meses de maio a novembro, alunos voluntários da graduação são selecionados e treinados para o desenvolvimento de palestras e para ministrá-las internamente aos alunos das Faculdades de Odontologia e Medicina Veterinária do Campus de Araçatuba ou à comunidade externa de outras universidades da cidade de Araçatuba e região, aos alunos de instituições estaduais, municipais e particulares do ensino fundamental, médio e superior, além de alunos de autoescolas.Algumas palestras também são concentradas entre os meses de agosto a outubro, conforme slogan anual adotado e união existente entre o CIRPAC e outros eventos externos programados por outras instituições.O projeto tem pretendido expandir a campanha de prevenção dos Traumatismos bucomaxilofaciais interagindo-a com a prevenção dos acidentes de trânsito, além de continuar atuando, junto aos órgãos públicos, no combate da violência na cidade de Araçatuba. Campanhas associadas aos fatores etiológicos dos traumas bucomaxilofaiciais poderão ser estendidas para outras regiões em um futuro próximo, conforme obtenção de recursos, auxílios e apoio dos órgãos públicos e da imprensa.Aproveito a oportunidade para agradecer ao periódico Archieves of Health Intvestigation, na pessoa da sua Editora Chefe, Profª. Associada Maria Cristina Rosifini Alves Rezende, pela honrosa oportunidade de publicar os resumos dos trabalhos apresentados no evento. Meus sinceros agradecimentos.Prof. Dr. Leonardo Perez FaveraniCoordenador
Modelling of nitrogen concentrations in water from drained peat soils
Authors: Vassiljev Anatoli , Annus Ivar , Kändler Nils , Kaur Katrin 
Published: November 2019

Abstract
In addition to traditional sources, drained peat soils have been found to be a significant source of nitrogen in Estonia. As a result, supplementary measures are required to improve water quality in rivers. Modelling is a widespread method to select means for improving water quality. At present, modelling of nitrogen in rivers has been concentrated on the influence of agricultural activity. However, drained peat can increase nitrogen concentrations even without fertilization and farming activities. This investigation describes the attempt to model water quality in the watershed with a large share of drained peat soils. The results showed a good alignment between measured and modelled nitrate concentrations using the MACRO and the SOILN for MACRO models. Some measures to improve water quality were tested using these models.
Insights into rainfall undercatch for differing raingauge rim heights
Authors: Muchan Katie , Dixon Harry 
Published: November 2019

Abstract
The measurement of rainfall has a long history, but despite its apparent simplicity it is difficult to quantify accurately. The common installation of raingauges with rims above the ground surface results in a difference between the rainfall caught and the amount reaching ground level, termed undercatch. The UK standard installation of raingauges is for their rim to be sited at 0.305 m above the ground; however, the use of weighing gauges installed at a minimum rim height of 1 m has increased in recent years. The installation of these weighing raingauges raises complex questions of homogeneity in rainfall data across space and time. Here, we investigate the impact of these changes using field trials of commonly deployed UK raingauges at a site in south-east England. This paper discusses the results of the trial, exploring the variation in and potential drivers of undercatch with differing gauge sitings. With varying standards for gauge heights around the world and new rainfall measurement technologies coming to the market all the time, improved understanding of undercatch is needed to inform evolving operational practices and explore the possibility of developing catch correction algorithms to remove arising inhomogeneity in precipitation datasets.
Synthesis, Characterization, Antimicrobial, Anti-tubercular, Antioxidant Activities and Docking Simulations of Derivatives of 2-(pyridin-3-yl)-1Hbenzo[ d]imidazole and 1,3,4-Oxadiazole Analogy
Authors: Bhati Shipra , Kumar Vijay , Singh Simranjeet , Singh Joginder 
Published: November 2019

Background:
Antimicrobial Resistance (AMR) and Tuberculosis (TB) are global
concern. According to the WHO fact sheet on tuberculosis, in 2017, 10 million people fell ill with
TB, and 1.6 million including 230,000 children died from the disease. There is a critical need of
design and development of novel chemotherapeutic agents to combat the emergence and increasing
prevalence of resistant pathogens. In the present study, a new series of 1,3,4-oxadiazoles
incorporating benzimidazole and pyridine scaffolds in a single molecular framework has been
reported.

Methods:
The structures of the synthesized derivatives (4a to 4e) were assigned by IR, NMR and
mass spectral techniques. The hybrid compounds were evaluated for their antimicrobial,
antitubercular and antioxidant activities. In addition, docking simulations were performed to study
ligand-protein interactions and to determine the probable binding conformations.

Results:
Molecule 4a has shown anti-tubular activities with MIC 1.6 μg/ml. As compared to
ascorbic acid activities (IC50 = 62.91 μg/ml), molecule 4e exhibited better antioxidant activities
(IC50 = 24.85 μg/ml). Also, molecule 4e has shown significant antimicrobial activities.

Conclusion:
The synthesized derivatives from 4a to 4e have exhibited various medicinal activities
and could be emerged as lead compounds and further explored as potential therapeutic agents.
Domestic Processing Effects on Antioxidant Capacity, Total Phenols and Phytate Content of Sorghum
Authors: Moraes Érica A. , de Oliveira Fernanda C.E. , Queiroz Valéria A. Vieira , Schaffert Robert E. , Cecon Paulo R. , Moreira Ana V. , Ribeiro Sônia M.R. , Martino Hércia S.D. 
Published: November 2019

Background:Whole grains may reduce chronic disease risks and these benefits are related to food matrix components, especially phenolic acids. However, food processing may change the total phenol content and antioxidant capacity.Objective:This study aims to evaluate the effect of processing on the antioxidant capacity and total phenols, tannins and phytate contents in the sorghum grain of seven genotypes.Methods:Antioxidant capacity (AC), total phenolic content (TPC), tannins and phytate content were evaluated in unheated sorghum grains (USG), heated sorghum grains (HSG) and popped sorghum grains (PSG) of seven genotypes.Results:AC ranged from 66.5% to 92.9% in USG, decreased after PSG in all genotypes, and maintained after HSG, except for BRS 506. TPC and tannins were higher in BRS 305. PSG decreased tannin content in all genotypes. TPC of HSG was higher than the USG in BRS 310, BRS 305, BR 501 and BR 700 genotypes. PSG affected TPC content mainly in BRS 305 and BR 700. AC and tannins were especially affected by the popping conditions. There was no difference in the phytate content among all genotypes, which were maintained after HSG in BRS 506, BRS 305, BR 700 and CMSXS 136.Conclusion:AC, TPC, tannins and phytate content were affected by the processing conditions, however, those changes may be related to the compounds type and sorghum genotype.
Parent Parenting with Aggressiveness
Authors: Jamaluddin Nuzliah , Andriyani Juli 
Published: November 2019

The background of the research is the use of parenting that is wrong from parents to children. The purpose of this research is to look at the relationship between parenting parents and the aggressiveness of students. This type of research is quantitative with a correlation approach. The sample in this study was 32 students and data collection techniques using a questionnaire and data analysis techniques using correlation analysis. Based on the analysis of the data it was revealed that 1) the aggressiveness of students in SMA Negeri 2 Indra Jaya was in the high group with a percentage of 43.7%, while the level of parenting (authoritarian) with a percentage of 40%, there was a significant relationship between parenting parents with aggressiveness students namely 0.608 with a strong correlation r value
Social Rehabilitation Constraintsin Children Facing the Laws Management
Authors: Ningrum Prike , Elfitra Elfitra , Alfiandi Bob 
Published: November 2019

Program rehabilitasi sosial Anak Berhadapan dengan Hukum (ABH) merupakan upaya pemerintah untuk pemenuhan hak-hak dasar ABH selama di Lembaga Penyelenggaraan Kesejahteraan Sosial yaitu Panti Sosial Asuhan Anak Bina Remaja Budi Utama. Terdapat kendala PSAABR melaksanakan rehabilitasi sosial ABH. Tujuan dari penelitian ini adalah untuk mengetahui kendala-kendala apa yang dialami oleh PSAABR dalam rehabilitasi sosial ABH. Teori yang digunakan adalah teori strukturasi yang dipelopori oleh Anthony Giddens yang memfokuskan pada hubungan dualitas antara agen dan struktur. Penelitian dilakukan dengan pendekatan hermeneutika ganda sebagai salah satu sub tipe riset kualitatif. Artikel ini akan menunjukkan bahwa kendala-kendala yang dihadapi pengelola PSAABR dalam rehabilitasi sosial ABH adalah kurangnya sumber daya manusia, minimnya anggaran dana untuk ABH, sarana dan prasarana yang kurang memadai, serta kurangnya pemahaman pengelola terkait metode penanganan ABH.Kata kunci: Anak, Hukum, Rehabilitasi, Sosial
Efektivitas Teknik Sosiodrama Untuk Meningkatkan Komunikasi Interpersonal Siswa (Penelitian Kuasi Eksperimen Kelas X di SMA Kartika Siliwangi 2 Bandung Tahun Ajaran 2013/2014)
Authors: Zuhara Evi 
Published: November 2019

Adolescence is a period of social adolescence because all social relationships is becoming more obvious and very dominant. Social relationship will be established with good interpersonal communication when there is in it. Students who have difficulty in interpersonal communication will be difficult to adjust themselves, tend to be overbearing, selfish, and want to win themselves so easily involved in the dispute. The aim of this research is intended to establish the effective interventions to improve students' interpersonal communication. The main of research problem was "Is sociodrama technique effective for enhancing studentsâ€™ interpersonal communication towards grade X students of Kartika Siliwangi 2 Senior High School in Bandung in academic year 2013/2014?" The research utilized quasi-experimental with Non equivalent Pretest-Posttest Control Group Design. The sample comprised 8 students in experiment group and 7 students in control group. The result showed that Sociodrama technique had a good effect to enhance studentsâ€™ interpersonal communication, which resulted in a significant increase in the change of interpersonal communication skills average score where the pretest was 21.50 and the posttest score was 44.60.

Masa remaja merupakan masa sosial karena sepanjang masa remaja hubungan sosial semakin tampak jelas dan sangat dominan. Hubungan sosial akan terjalin dengan baik apabila terdapat komunikasi interpersonal di dalamnya. Siswa yang memiliki kesulitan dalam melakukan komunikasi interpersonal akan sulit menyesuaikan diri, cenderung memaksakan kehendak, egois, dan ingin menang sendiri sehingga mudah terlibat dalam perselisihan. Penelitian bertujuan menghasilkan rumusan intervensi yang efektif untuk meningkatkan komunikasi interpersonal siswa. Masalah utama penelitian adalah â€œApakah teknik sosiodrama efektif untuk meningkatkan komunikasi interpersonal siswa kelas X Kartika Siliwangi 2 Bandung Tahun Ajaran 2013/2014?â€ Metode penelitian yang digunakan yaitu kuasi eksperimen dengan Non equivalent Pretest-Posttest Control Group Design. Sampel penelitian sebanyak 15 siswa, dengan jumlah anggota kelompok eksperimen 8 siswa pada kelompok kontrol 7 siswa. Teknik sosiodrama untuk meningkatkan komunikasi interpersonal siswa yang diujikan dalam penelitian memiliki daya pengaruh yang cukup baik, yaitu menghasilkan peningkatan yang signifikan perubahan skor rata-rata kemampuan komunikasi interpersonal pada saat pretest sebesar 21,50 mengalami peningkatan menjadi
44.60 pada saat posttest.

Kata Kunci: Komunikasi Interpersonal, Siswa SMA, Teknik Sosiodrama.
Epistaxis Due to Platelet Dysfunction in a Healthy Person During Office Reconstruciton
Authors: Denic Srdjan , Souid Abdul-Kader 
Published: November 2019

A healthy 63-year-old male developed severe unprovoked recurrent nose bleeding over a 40-day period. He had no other symptoms and his past-medical and family histories were non-contributory. His physical examination, complete blood counts, and coagulation profile were normal. Three weeks into the illness, a platelet function screen was found abnormal. Hematology consultation did not find a cause for his thrombasthenia. After a short hospitalization for severe epistaxis, recurrent nosebleeds stopped. Several months later, the platelet function screen was normal. Post-hoc review of history found that the onset and duration of his nose bleeding and platelet dysfunction coincided with office reconstruction, which generated a strong aromatic smell. He was physically closer to the reconstruction site than unaffected co-workers. There was a temporal relation between the intensity of exposer to office environment and the intensity of bleeding. It is probable that the cause of his platelet dysfunction was an inhaled unidentified toxic chemical(s). The management of his epistaxis and risk of inhalation of toxins as a cause of platelet dysfunction are discussed.
Seroprevalence and Real-time PCR Detection of Brucellosis in Abattoirs Animals as a Potential Route of Infection in Egypt
Authors: Zakaria Amira Mohamed , Ahmed Salwa F. , Motawae Mohamed S. 
Published: November 2019

Brucellosis is among the most common and economically serious zoonosis worldwide. Brucellosis in Egypt is an endemic problem among animals and humans. This work intended to evaluate the conventional serological and molecular approaches as a tool for studying the prevalence of brucellosis within abattoir’s animals in two large Egyptian provinces. Two hundred and thirty (n=230) blood and serum samples were collected from (2-3) years male calves in two Egyptian abattoirs. Rose Bengal test (RBT) and modified in-house ELISA were applied to determine the seroprevalence of Brucellosis in abattoirs animals while quantitative Taqman real-time PCRs (RT-PCR) were implemented for the characterization of Brucella species. The overall prevalence of brucellosis in the two proveinces was (53.9 %) , (75.2 %) and (79.1 %) as determined by ELISA ,RBT and RT- PCR assays respectively. Brucella DNA was successfully amplified from serum samples as well as blood. A total of n= 182 samples (79.1 %) were identified by real time PCR amplification for IS711 gene as Brucella genus, n= 118 (64.8 %) were reported as B. aborts while n= 85 (46.7 %) were reported as B. melitensis. N= 44 (24.17 %) from the collected samples comprised the two species of bacteria. This study endorses the application of rose Bengal test as a sensitive and cost effective serological test for brucellosis and real-time PCR as a distinguishing tool to detect the causative agents. Our findings indicate a significantly high prevalence of Brucella antibodies and DNA in blood and serum samples which poses a crucial threat to public health in Egypt.
Effect of Diode Laser on Human Cytomegalovirus and Epstein - Barr Virus in Chronic Periodontitis Patients – A Quantitative Real-Time Polymerase Chain Reaction Study
Authors: Prabhu Sandeep S. , Kripal Krishna , R. Deepthi , M.P. Rakesh , S.M. Manjunath , P. Shanmugapriya 
Published: November 2019

Background and aims: Studies have investigated the occurrence of Human cytomegalovirus (HCMV) and Epstein Barr Virus (EBV) in samples of both chronic and aggressive periodontitis lesions and their role in the pathogenesis of the disease have been suggested. It is important to determine the role and presence of these viruses in chronic generalized periodontitis patients after Scaling and root planing (SRP) alone and in conjunction with diode laser application. Thus the aim of the present study was to determine the prevalence of human cytomegalovirus (HCMV), Epstein–Barr virus(EBV) in gingival crevicular fluid (GCF) samples obtained from chronic generalised periodontitis patients.
Materials (Subjects) and Methods: A total of 30 patients were included in the study based on the inclusion and exclusion criteria as follows: Group I – 15 chronic generalized periodontitis patients who received treatment with scaling and root planing. Group II – 15 chronic generalized periodontitis patients who received treatment with scaling and root planing and Diode laser. In each patient GCF samples were collected at baseline, 7 days and 21 days after treatment. Clinical parameters like gingival index, probing pocket depth and clinical attachment level were recorded and as GCF samples collected.
Results: Correlation between quantification of EBV values with clinical parameters such as gingival index, probing pocket depth and clinical attachment loss in two groups showed statistical significance (P < 0.001). Relative quantification of EBV was statistically significant, whereas HCMV was significantly absent. The mean values of GI, PPD and CAL parameters at different time interval was found to be statistically significant in both group (P < 0.001)
Conclusions: Only EBV was detected more frequently in patients with CGP, but HCMV was not detected with similar frequency in the groups studied. We also found that group with application of diode laser showed statistical significant results.