bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Life and Letters of William Sharp and "Fiona Macleod"
Authors: Halloran William F. 
Published: April 2020

William Sharp (1855-1905) conducted one of the most audacious literary deceptions of his or any time. Sharp was a Scottish poet, novelist, biographer and editor who in 1893 began to write critically and commercially successful books under the name Fiona Macleod. This was far more than just a pseudonym: he corresponded as Macleod, enlisting his sister to provide the handwriting and address, and for more than a decade "Fiona Macleod" duped not only the general public but such literary luminaries as William Butler Yeats and, in America, E. C. Stedman.
Sharp wrote "I feel another self within me now more than ever; it is as if I were possessed by a spirit who must speak out". This three-volume collection brings together Sharp’s own correspondence – a fascinating trove in its own right, by a Victorian man of letters who was on intimate terms with writers including Dante Gabriel Rossetti, Walter Pater, and George Meredith – and the Fiona Macleod letters, which bring to life Sharp’s intriguing "second self".
With an introduction and detailed notes by William F. Halloran, this richly rewarding collection offers a wonderful insight into the literary landscape of the time, while also investigating a strange and underappreciated phenomenon of late-nineteenth-century English literature. It is essential for scholars of the period, and it is an illuminating read for anyone interested in authorship and identity.
Margery Spring Rice
Authors: Pollard Lucy 
Published: April 2020

This book vividly presents the story of Margery Spring Rice, an instrumental figure in the movements of women’s health and family planning in the first half of the twentieth century. Margery Spring Rice, née Garrett, was born into a family of formidable female trailblazers – niece of physician and suffragist Elizabeth Garrett Anderson, and of Millicent Fawcett, a leading suffragist and campaigner for equal rights for women. Margery Spring Rice continued this legacy with her co-founding of the North Kensington birth control clinic in 1924, three years after Marie Stopes founded the first clinic in Britain.
Engaging and accessible, this biography weaves together Spring Rice’s personal and professional lives, adopting a chronological approach which highlights how the one impacted the other. Her life unfolds against the turbulent backdrop of the early twentieth century – a period which sees the entry of women into higher education, and the upheaval and societal upshots of two world wars. Within this context, Spring Rice emerges as a dynamic figure who dedicated her life to social causes, and whose actions time and again bear out her habitual belief that, contrary to the Shakespearian dictum, ‘valour is the better part of discretion’.
This is the first biography of Margery Spring Rice, drawing extensively on letters, diaries and other archival material, and equipping the text with family trees and photographs. It will be of great interest to a range of social historians, especially those researching the birth control movement; female friendships, female philanthropists, and feminist activism in the twentieth century; and the history of medicine and public health.
Tracking Air–Sea Exchange and Upper-Ocean Variability in the Indonesian–Australian Basin during the Onset of the 2018/19 Australian Summer Monsoon
Authors: Feng Ming , Duan Yongliang , Wijffels Susan , Hsu Je-Yuan , Li Chao , Wang Huiwu , Yang Yang , Shen Hong , Liu Jianjun , Ning Chunlin , Yu Weidong 
Published: April 2020

AbstractSea surface temperatures (SSTs) north of Australia in the Indonesian–Australian Basin are significantly influenced by Madden–Julian oscillation (MJO), an eastward-moving atmospheric disturbance that traverses the globe in the tropics. The region also has large-amplitude diurnal SST variations, which may influence the air–sea heat and moisture fluxes, that provide feedback to the MJO evolution. During the 2018/19 austral summer, a field campaign aiming to better understand the influences of air–sea coupling on the MJO was conducted north of Australia in the Indonesian–Australian Basin. Surface meteorology from buoy observations and upper-ocean data from autonomous fast-profiling float observations were collected. Two MJO convective phases propagated eastward across the region in mid-December 2018 and late January 2019 and the second MJO was in conjunction with a tropical cyclone development. Observations showed that SST in the region was rather sensitive to the MJO forcing. Air–sea heat fluxes warmed the SST throughout the 2018/19 austral summer, punctuated by the MJO activities, with a 2°–3°C drop in SST during the two MJO events. Substantial diurnal SST variations during the suppressed phases of the MJOs were observed, and the near-surface thermal stratifications provided positive feedback for the peak diurnal SST amplitude, which may be a mechanism to influence the MJO evolution. Compared to traditionally vessel-based observation programs, we have relied on fast-profiling floats as the main vehicle in measuring the upper-ocean variability from diurnal to the MJO time scales, which may pave the way for using cost-effective technology in similar process studies.
Outcomes of older patients with NPM1-mutated AML: current treatments and the promise of venetoclax-based regimens
Authors: Lachowiez Curtis A. , Loghavi Sanam , Kadia Tapan M. , Daver Naval , Borthakur Gautam , Pemmaraju Naveen , Naqvi Kiran , Alvarado Yesid , Yilmaz Musa , Short Nicholas , Ohanian Maro , Pierce Sherry R. , Patel Keyur P. , Qiao Wei , Ning Jing , Sasaki Koji , Takahashi Koichi , Jabbour Elias , Andreeff Michael , Ravandi Farhad , Kantarjian Hagop M. , Konopleva Marina , DiNardo Courtney D. 
Published: April 2020

Abstract
Nucleophosmin-1 mutations (NPM1+) occur in ∼30% of acute myeloid leukemia (AML) patients. Although typically associated with favorable prognosis, the beneficial impact of NPM1+ decreases with increasing age in patients treated with standard intensive chemotherapy (IC) or hypomethylating agents (HMAs). This retrospective analysis compared outcomes of NPM1+ AML patients treated with 1 of 3 induction approaches: HMA plus BCL-2 inhibitor venetoclax (VEN), HMA, or IC therapy. Composite complete response (CRc: CR + CR with incomplete count recovery) was seen in 96% (27/28), 36% (17/47), and 89% (204/228) of HMA + VEN, HMA, and IC patients, respectively (HMA + VEN vs HMA, P &lt; .001; HMA + VEN vs IC, P = .10). Older patients (age &gt;65 years) treated with HMA + VEN, HMA, or IC had CR rates of 88%, 28%, and 56%, respectively (HMA + VEN vs HMA, P &lt; .001; HMA + VEN vs IC, P = .01). Significant improvement in overall survival (OS) was seen in patients age &gt;65 years treated with HMA + VEN vs HMA (not reached [NR] vs 0.4 years; P &lt; .001) or IC (NR vs 0.93 years; P = .001). Older patients treated with HMA + VEN had OS of 80% after median 1-year follow-up, with estimated 2-year OS of 70%. In the multivariable Cox model analysis, HMA + VEN was associated with a 69% lower risk of death compared with IC (hazard ratio, 0.31; 95% confidence interval, 0.12-0.83; type I error–adjusted P = .038). HMA + VEN combinations demonstrated impressive results compared with traditional standard-of-care regimens in older patients with NPM1+ AML.
Coloring mechanisms of ancient buried wood: Japanese cedar trees excavated from the foothills of Mt. Chokai
Authors: Kurimoto Yasuji , Yamauchi Shigeru , Takayama Tsutomu , Sakai Yoichi 
Published: April 2020

AbstractSpectroscopic characterization of ancient buried Japanese cedar (Cryptomeria japonica) woods excavated from the foothills of Mt. Chokai was carried out to investigate the factors governing their color tones. X-ray fluorescence analysis confirmed primary metal elements in the Japanese cedar wood to be Ca and Fe. Infrared photoacoustic spectroscopy revealed that prolonged burial had not caused severe chemical decomposition of the ancient wood. 57Fe Mössbauer spectra of the ancient wood samples suggested that Fe in the Japanese cedar wood was present in the high-spin Fe3+ or low-spin Fe2+ state. Although the dark color tone of the ancient wood has been assumed to be due to the presence of multinuclear Fe complexes with multidentate ligands such as tannin, no positive correlation was observed between the color depth and Fe content of the ancient wood samples.
When piloting health services interventions, what predicts real world behaviours? A systematic concept mapping review
Authors: Hayes Tavis , Hudek Natasha , Graham Ian D. , Coyle Doug , Brehaut Jamie C. 
Published: April 2020

AbstractBackgroundModeling studies to inform the design of complex health services interventions often involves elements that differ from the intervention’s ultimate real-world use. These “hypothetical” elements include pilot participants, materials, and settings. Understanding the conditions under which studies with “hypothetical” elements can yield valid results would greatly help advance health services research. Our objectives are:1) to conduct a systematic review of the literature to identify factors affecting the relationship between hypothetical decisions and real-world behaviours, and 2) to summarise and organize these factors into a preliminary framework.MethodsWe conducted an electronic database search using PsycINFO and Medline on November 30th, 2015, updated March 7th, 2019. We also conducted a supplemental snowball search on December 9th 2015 and a reverse citation search using Scopus and Web of Science. Studies were eligible to be included in this review if they clearly addressed the consistency between some type of hypothetical decision and a corresponding real decision or behaviour. Two reviewers extracted data using a standardized data collection form developed through an iterative consensus-based process. We extracted basic study information and data about each study’s research area, design, and research question. Quotations from the articles were extracted and summarized into standardized factor statements.ResultsOf the 2444 articles that were screened, 68 articles were included in the review. The articles identified 27 factors that we grouped into 4 categories: decision maker factors, cognitive factors, task factors, and matching factors.ConclusionsWe have summarized a large number of factors that may be relevant when considering whether hypothetical health services pilot work can be expected to yield results that are consistent with real-world behaviours. Our descriptive framework can serve as the basis for organizing future work exploring which factors are most relevant when seeking to develop complex health services interventions.
International tuberculosis contact-tracing notifications in Germany: analysis of national data from 2010 to 2018 and implications for efficiency
Authors: Glasauer Saskia , Kröger Stefan , Haas Walter , Perumal Nita 
Published: April 2020

Abstract
Background
International contact-tracing (CT) following exposure during long-distance air travel is resource-intensive, whereas evidence for risk of tuberculosis (TB) transmission during international travel is weak. In this study, we systematically analyzed the information from international requests for CT received at the national level in Germany in order to evaluate the continued utility of the current approach and to identify areas for improvement.

Methods
An anonymized archive of international CT notifications received by the Robert Koch Institute between 2010 and 2018 was searched for key parameters for data collection. A total of 31 parameters, such as characteristics of TB patients and their identified contacts, were extracted from each CT notification and collated into a dataset. Descriptive data analysis and trend analyses were performed to identify key characteristics of CT notifications, patients, and contacts over the years.

Results
192 CT notifications, each corresponding to a single TB index case, were included in the study, increasing from 12 in 2010 to 41 in 2018. The majority of notifications (N = 130, 67.7%) concerned international air travel, followed by private contact (N = 39, 20.3%) and work exposure (N = 16, 8.3%). 159 (82.8%) patients had sputum smear results available, of which 147 (92.5%) were positive. Of 119 (62.0%) patients with drug susceptibility testing results, most (N = 92, 77.3%) had pan-sensitive TB, followed by 15 (12.6%) with multi-drug resistant TB. 115 (59.9%) patients had information on infectiousness, of whom 99 (86.1%) were considered infectious during the exposure period. 7 (5.3%) patients travelled on long-distance flights despite a prior diagnosis of active TB. Of the 771 contact persons, 34 (4.4%) could not be reached for CT measures due to lack of contact information.

Conclusion
The high variability in completeness of information contained within the international CT requests emphasizes the need for international standards for reporting of CT information. With the large proportion of TB patients reported to have travelled while being infectious in our study, we feel that raising awareness among patients and health professionals to detect TB early and prevent international long-distance travel during the infectious disease phase should be a cornerstone strategy to safeguard against possible transmission during international travel.
Cortical unlike trabecular bone loss is not associated with vascular calcification progression in CKD patients
Authors: Costa Larissa R. , Carvalho Aluizio B. , Bittencourt Amandha L. , Rochitte Carlos E. , Canziani Maria Eugênia F. 
Published: April 2020

Abstract
Background
Vascular calcification progression has been associated with the loss of trabecular bone in chronic kidney disease (CKD) patients. There are few data evaluating the relationship between cortical bone loss and vascular calcification in this population. The aim of this study was to prospectively evaluate the association between changes in cortical bone density and coronary artery calcification (CAC) progression in non-dialyzed CKD patients.

Methods
Changes of cortical and trabecular bone, and changes of calcium score, were analyzed using vertebral tomographic images from a prospective study. Automatic delineation of the cortical bone layer was performed by Image J software, and trabecular bone was determined by selecting a region of interest using Vitrea 2® software. Cortical and trabecular bone density (BD) were expressed in Hounsfield Units (HU), and coronary artery calcium score in Agatston Units (AU).

Results
Seventy asymptomatic patients [57.8 ± 10.2 years, 63% males, 20% diabetic, estimated glomerular filtration rate (eGFR) = 37.3 (24.8–51.3) mL/min/1.73m2] were followed for 24 months. The mean cortical and trabecular BD did not change over time. While 49 patients lost either bone, 29 (41%) patients lost cortical [− 4.4%/year (ranging from − 7.15 to − 0.5)] and 39 (56%) lost trabecular bone [− 3.15%/year (− 13.7 to − 0.25)]. There was no association between cortical and trabecular BD changes (p = 0.12). CAC was observed in 33 (46%) patients at baseline, and 30 (91%) of them showed CAC progression. While an inverse correlation between trabecular bone and calcium score changes was observed (p = 0.001), there was no correlation between cortical bone and calcium score changes (p = 0.34).

Conclusion
CKD patients experience either cortical or trabecular bone loss over time, but these changes do not take place simultaneously in all patients. Cortical, unlike trabecular bone loss, is not associated with vascular calcification progression in these patients.
The impact of hyperglycemia on urinary albumin excretion in recent onset diabetes mellitus type II
Authors: Nikolaidou Barbara , Gkaliagkousi Eugenia , Anyfanti Panagiota , Gavriilaki Eleni , Lazaridis Antonios , Triantafyllou Areti , Zografou Ioanna , Douma Stella 
Published: April 2020

Abstract
Background
Increased urinary albumin excretion (UAE) in diabetes is a sensitive marker of microvascular injury and a reliable predictor of cardiovascular outcomes. Hypertension-induced hemodynamic pressure load, diabetes-related metabolic processes and large artery stiffening have all been implicated in the development of microalbuminuria. We investigated whether hyperglycemia per se, or rather increased blood pressure (BP) and macrovascular dysfunction, is a stronger predictor of UAE at the earliest stages of diabetes.

Methods
Consecutive newly diagnosed patients with diabetes type 2, who were normoglycemic within a year’s time prior to diagnosis, were enrolled. UAE was estimated in 24-h urine samples. Both office and 24-h ambulatory BP was recorded. Arterial stiffness was evaluated by measurement of carotid-femoral pulse wave velocity (PWV) with applanation tonometry.

Results
Among 71 newly diagnosed patients with median diabetes duration of just 1 month, 15.5% presented microalbuminuria. UAE did not differ between hypertensive and normotensive diabetics; however, newly diagnosed patients for both hypertension and diabetes exhibited significantly higher levels of UAE, compared to diabetic patients with long-standing hypertension. UAE strongly and significantly correlated with office systolic BP, HbA1c, PWV and estimated glomerular filtration rate. However, in the multivariate analysis adjusting for these factors, only HbA1c was independently associated with UAE (beta = 0.278, p = 0.049).

Conclusions
Hyperglycemic state emerges as a powerful predictor of increased UAE even at the earliest stages of diabetes. The relative contribution of hypertension and macrovascular dysfunction to the development of microalbuminuria seems to be obscured by hyperglycemia, even in patients whose diabetes onset does not exceed a few months’ time.
Beta-glucans in advanced CKD: role in endotoxaemia and inflammation
Authors: Wong Jonathan , Zhang Yonglong , Swift Oscar , Finkelman Malcolm , Patidar Ashish , Ramanarayanan Sivaramakrishnan , Vilar Enric , Farrington Ken 
Published: April 2020

AbstractBackground/aims(1–3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. BG can also induce false positive signals in endotoxin detection assays (Limulus Amoebocyte Lysate [LAL] assay). We explored the relationship between BG levels, renal impairment, endotoxaemia and inflammation.MethodsWe measured serum BG levels, markers of inflammation and blood endotoxin levels in 20 controls, 20 with stages 1–3 chronic kidney disease (CKD), 20 with stages 4–5 CKD, 15 on peritoneal dialysis (PD) and 60 on haemodialysis (HD). Another 30 patients were studied before and after HD initiation.ResultsBG levels increased with advancing CKD, being highest in HD patients, 22% of whom had elevated levels (> 80 pg/ml). Levels increased significantly following HD initiation. Levels also correlated positively with CRP, TNFα, IL-6 levels, independently of CKD stage. Blood endotoxin was detectable by LAL assays in 10–53% of the CKD cohort, being most prevalent in the HD group, and correlating positively with BG levels. Adding BG blocking agent to the assay reduced endotoxin detection confining it to only 5% of HD patients. Levels of inflammatory markers were higher in those with detectable endotoxin - whether false- or true positives.ConclusionBG levels increased with decreasing renal function, being highest in dialysis patients. High BG levels were associated with false positive blood endotoxin signals, and with markers of inflammation, independently of CKD stage. The cause for high BG levels is unknown but could reflect increased gut permeability and altered mononuclear phagocytic system function.
Genetic analysis of spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord: a case series
Authors: Bartels Ronald H. M. A. , Grotenhuis J. Andre , Stegmann Alexander P. A. , Brunner Han 
Published: April 2020

Abstract
Background
Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple factors, including a genetic factor. A common genetic defect in patients with a spinal dysraphism with a hamartomatous growth of the spinal cord is sought for.

Case presentation
In two patients with a symptomatic lesion and referred to an academic hospital a genetic analysis was performed after informed consent. Whole-exome analysis was performed.
: Whole-exome analysis did not result in identification of a clinically relevant genetic variant.

Conclusions
This the first study to investigate the genetic contribution to spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord. We could not establish a genetic cause for this entity. This conclusion cannot be definitive due to the small sample size. However, the incidental occurrence, the lack of reports of inheritance of this disorder and the absence of contribution to syndromal disorders favours a defect of normal development of the spinal cord.
Current heterosexual marriage is associated with significantly decreased levels of anxiety symptoms among Chinese men who have sex with men
Authors: Yang Zuosen , Li Shuang , Zhang Rui , Na Jun , Li Yanxia , Mu Huijuan , Yu Liya , Liu Li , Sun Wei , Pan Guowei , Yan Lingjun 
Published: April 2020

Abstract
Background
The high heterosexual marriage rate could be a ‘double-edge’ sword for the emotional health of Chinese men who have sex with men (MSM). The aim of this study was to determine if current marriage and breakdown of marriage (divorce) have different effects on the mental health of Chinese MSM.

Methods
Eight hundred seven MSM were recruited using respondent-driven sampling from four cities in northeastern China. Gay-related stressful events (GRSE) were measured using the Gay Related Stressful Life Events Scale; social support was measured by the Social Support Rating Scale (SSRS); and depressive and anxiety symptoms were assessed using the Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS), respectively.

Results
Of the study participants, 13.4% were married to women and 4.5% were divorced. The rates of marriage or divorce were 35.3 and 75.8% for participants 30–39 and > 40 years of age, respectively. The current married MSM had the highest SDS (50.0 ± 10.9) and SSRS (35.8 ± 8.6) levels, but the lowest SAS (38.7 ± 12.1) levels. Divorced MSM had the highest SAS (44.4 ± 9.6) and lowest SSRS (30.8 ± 8.1) levels. Age, GESE number, and HIV infection were predictors for SDS and SAS, and current marriage was associated with significantly decreased level of SAS (β = − 0.136, P = 0.001) based on multiple linear analysis.

Conclusions
Current marriage is associated with significantly decreased levels of anxiety symptoms among Chinese MSM. More studies are needed to understand the mechanisms underlying the effects of different marriage status on the emotional distress of Chinese MSM.