bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMA: Des échelles d’évaluation motrice pour le public francophone
Authors: Pons Christelle , Barrière Aurélie , Bertrand Guillaume , Morard Marie-Doriane , Lilien Charlotte , Vuillerot Carole 
Published: December 2019

À l’heure des nouvelles thérapeutiques chez les personnes présentant une amyotrophie spinale antérieure ou spinal muscular atrophy (SMA), la mesure régulière, précise et fiable des capacités motrices est devenue indispensable. Différents outils ont été développés dans la littérature et peuvent être utilisés pour cela. Le choix d’une échelle/ d’un outil se fait en fonction du type de SMA, de l’âge de la personne et des éléments spécifiques de la motricité que l’on souhaite évaluer. En France, l’échelle MFM est utilisée en pratique clinique dans de nombreux centres de référence de Maladies Neuromusculaires (MNM). Les autres échelles fréquemment utilisées au niveau international ne sont cependant pas disponibles en français rendant leur utilisation plus difficile en pratique clinique courante.
Cet article présente le processus de traduction en français des échelles les plus fréquemment utilisées chez la personne avec SMA (CHOP INTEND, HFMSE, RULM, 6-minute walk test et HINE-2). Différentes étapes ont été respectées, notamment les étapes de traduction en français, traduction inversée en anglais, comparaison des versions anglaises, harmonisation et obtention de la version finale en français.
Un programme de formation et sensibilisation des différents professionnels des consultations MNM des centres de référence français avec proposition d’ateliers en présence des membres du comité scientifique suivra l’étape de traduction afin de les faire connaître, expliciter leur utilisation et participer à la diffusion de ce travail.
La conquête du désir : pas sans le deuil
Authors: Brient Pierrick 
Published: December 2019

Cet article pose la question de la place du désir dans les approches centrées sur les troubles de l’humeur. Reprenant la problématique désirante, nous essayons de montrer ce qui spécifie le désir du névrosé et comment le parcours analytique va permettre au sujet de trouver les voies de l’objet véritable qui fonde son être. Pour approfondir cette question, nous revenons à la tragédie d’Hamlet avec le commentaire que Lacan en a proposé dans son séminaire Le désir et son interprétation. Hamlet se présente comme un miroir qui exemplifie la tragédie du désir. L’obstacle œdipien, l’interdit du père, la voracité maternelle, vectorisent une position subjective aliénée qui ne pourra trouver sa solution que dans un passage à l’acte dans le même temps auto et hétéro-agressif. La façon dont le désir sera rectifié, passant par la reconnaissance du manque au champ de l’Autre, met l’accent sur la nécessité d’un deuil comme renoncement à la jouissance, ouvrant à une éthique du désir. Celle-ci identifie l’angoisse comme seul affect qui ne trompe pas, a contrario de la lâcheté morale qu’implique la dépression et situant du même coup la « bipolarité » comme refus de savoir. Ce qui est à savoir concerne le deuil du phallus d’où le sujet s’est fait être dans le désir de la mère, deuil du phallus qui permet l’assomption de son être-pour-la-mort là où dominait la lâcheté morale.
Therapie der idiopathischen Kopfschmerzen im Kindes- und Jugendalter
Authors: Kiep Henriette , Bernhard Matthias K. , Merkenschlager Andreas 
Published: December 2019

ZUSAMMENFASSUNGMigräne und Spannungskopfschmerzen sind die häufigsten idiopathischen Kopfschmerzsyndrome im Kindes- und Jugendalter. Aufgrund ihrer hohen Prävalenz und dem oft hohen Leidensdruck bei den Betroffenen sind sie ein häufiger Grund für Vorstellungen im ambulanten oder stationären Setting. Dieser Artikel fasst die aktuelle Literatur und die Empfehlungen zur Akuttherapie und prophylaktischen Behandlung von Migräne und Spannungskopfschmerzen zusammen.
Mediendarstellungen der HIV-PrEP: Inhaltsanalytische Befunde zu Presse, Web und Sozialen Medien
Authors: Döring Nicola , Walter Roberto , Knutzen Kathrin 
Published: December 2019

Zusammenfassung
Einleitung Die orale HIV-Prä-Expositions-Prophylaxe (kurz HIV-PrEP, PrEP) ist eine relativ neue Methode der HIV-Prävention. Sie ist ein Medikament, mit dem sich HIV-negative Personen vor einer HIV-Infektion schützen können, etwa bei kondomlosem Sex mit einer HIV-positiven Person. Die Entwicklung und Einführung der PrEP wurde und wird von kontroversen fachlichen und medienöffentlichen Debatten begleitet. Bisherige Studien weisen auf ein überwiegend negatives Framing der PrEP in anglo-amerikanischen Medienbeiträgen hin.
Forschungsziele Vor dem Hintergrund der kommunikationswissenschaftlichen Framing-Theorie war es Ziel der vorliegenden Studie herauszuarbeiten, wie die HIV-PrEP in deutschsprachigen Medienbeiträgen in Presse, Web und Sozialen Medien dargestellt wird. Dabei ging es um die Gesamtbewertung der PrEP (generisches PrEP-Framing), um Pro- und Contra-Argumente zur PrEP (themenspezifische PrEP-Sub-Frames) sowie um die angesprochenen PrEP-Zielgruppen.
Methoden Mittels manueller quantitativer Medieninhaltsanalyse wurden eine Stichprobe von N = 150 Presseartikeln und N = 150 Webseiten zur PrEP mit einem auf Reliabilität geprüften Codebuch untersucht. Zudem wurden PrEP-bezogene Beiträge auf YouTube, Facebook und Twitter qualitativ erkundet. Die Studie folgt dem Open-Science-Ansatz: Sie wurde präregistriert und alle Instrumente, Datensätze und statistischen Auswertungsskripts sind über den Server der Open Science Foundation verfügbar (https://osf.io/as6bx/).
Ergebnisse Es zeigte sich, dass die PrEP in deutschsprachigen Medien in einem positiveren Bedeutungsrahmen erscheint als in anglo-amerikanischen Medien. Im Vergleich zu den Presseartikeln wurde die PrEP auf den untersuchten Webseiten signifikant positiver dargestellt. Eine Stigmatisierung von PrEP-Nutzenden als verantwortungslos erfolgte in der Presse doppelt so oft wie im Web. Sowohl in der Presse als auch im Web wurden mehrheitlich Männer, die Sex mit Männern haben, als PrEP-Zielgruppe angesprochen. Deutschsprachige PrEP-Informationen sind in Sozialen Medien teilweise äußerst rar (z. B. auf YouTube).
Schlussfolgerung Um die PrEP-Aufklärung der Allgemeinbevölkerung voranzutreiben, ist eine intensivere und differenziertere Repräsentation der PrEP in alten wie neuen Medien wünschenswert.
Perspektive eines PrEP-Nutzers auf die PrEP
Authors: Schock Axel 
Published: December 2019

ZusammenfassungMilan (Pseudonym) ist zum Zeitpunkt des Interviews im Herbst 2018 27 Jahre alt und lebt in Deutschland. Als er im Rahmen der klinischen Studie DISCOVER mit der Einnahme der HIV-Prä-Expositions-Prophylaxe (HIV-PrEP) begann, war er als Single in der Schwulen-Szene unterwegs. Inzwischen lebt er in einer festen Partnerschaft. Warum er trotzdem weiterhin die PrEP einnimmt und wie es ihm damit geht, erzählt er im Interview mit Axel Schock.
Die Hufelandgesellschaft: der Dachverband für eine Integrative Medizin
Authors: Heinze Sigrid 
Published: December 2019

SummaryDie Hufelandgesellschaft ist der Dachverbandder Ärztegesellschaften aus dem Bereichder Naturheilverfahren, deranthroposophischenMedizin, der Homöopathie, derAyurveda-Medizin und weiteren komplementärenVerfahren und vertritt dieInteressenihrer Mitglieder gegenüber Politik undGesellschaft. Als ärztlicher Dachverbandsetzt sie sich dafür ein, dass dieKomplementärmedizinbesser erforscht werden kann,Teil jeder medizinischen Ausbildung wirdund für jeden Menschen verfügbar ist.
Protective Effects of Bergamot (Citrus bergamia Risso & Poiteau) Juice in Rats Fed with High-Fat Diet
Authors: De Leo Marinella , Piragine Eugenia , Pirone Andrea , Braca Alessandra , Pistelli Luisa , Calderone Vincenzo , Miragliotta Vincenzo , Testai Lara 
Published: December 2019

AbstractThe bergamot (Citrus bergamia Risso & Poiteau), a small tree cultivated along the Ionian coast of the Calabria region in Southern Italy, is an ancient plant used for the production of essential oil from fruit peel, but recently evaluated also for the high content of phenolics in the fruit pulp. Indeed, the juice is rich in glycosylated flavone and flavanones, showing a wide range of pharmacological activities. Noteworthy preclinical and clinical studies reported that bergamot juice is effective in reducing plasma lipids. The aim of this study was to evaluate the beneficial effects of a C. bergamia juice using an experimental animal model of metabolic syndrome and cardiovascular risk in vivo. A significant reduction of both triglyceride levels and cardiovascular risk was observed in animals fed with a high-fat diet and bergamot juice. Daily oral treatment with bergamot juice significantly limits a high-fat-induced increase in body, visceral adipose tissue, liver, and heart weight. In addition, C. bergamia juice showed protective effects on hepatic steatosis, probably due to the reduction of oxidative stress and inflammation. Chemical constituents of administered bergamot juice, investigated by means of liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analyses were represented by a wide range of flavonoids, with neohesperidin, neoeriocitrin, and naringin being the most abundant flavonoids according to previous studies. Furthermore, a considerable amount of brutieridin, a flavanone O-glycoside having a 3-hydroxy-3-methyl-glutaryl residue, was observed.
Recent Advances in Chromium-Catalyzed Organic Transformations
Authors: Zeng Xiaoming 
Published: December 2019

The use of simple and low-cost chromium chloride salts as catalysts or precatalysts for the development of cost-effective methods is of significant synthetic and mechanistic interest. Here, recent advances in chromium-catalyzed organic transformations are highlighted.1	Introduction2	Arylmagnesiation of Alkynes3	Catalytic Functionalization of C(aryl)–O Bonds4	Catalytic Functionalization of C(aryl)–N Bonds5	Catalytic Functionalization of C(aryl)–H Bonds6	NHK-Type Reactions7	Hydrogenation8	Conclusions
Fatores de risco para osteólise do enxerto do coracoide após o procedimento de Latarjet aberto
Authors: Cohen Marcio , Zaluski Alexandre Dreifus , Siqueira Glaucio Sales de Lima , Amaral Marcus Vinicius Galvão , Monteiro Martim Teixeira , Filho Geraldo Rocha Motta 
Published: December 2019

Resumo
Objetivo Osteólise do processo coracoide é descrita como uma possível complicação da cirurgia de Latarjet. O objetivo do presente estudo foi avaliar a incidência e fatores de risco associados à osteólise do enxerto do coracoide e correlacioná-los com resultados clínicos.
Métodos Foi realizada uma revisão retrospectiva incluindo 38 casos submetidos ao procedimento de Latarjet. Em todos os casos, foi realizada uma tomografia computadorizada antes e pelo menos 1 ano após a cirurgia. A presença de osteólise do coracoide foi avaliada e correlacionada com os seguintes fatores de risco: idade, tabagismo, e perda óssea pré-operatória da glenóide. Os pacientes foram divididos em dois grupos: A (ausência ou menor reabsorção óssea) e B (maior reabsorção óssea ou total). A avaliação funcional foi determinada através do escore de Rowe.
Resultado Osteólise do processo coracoide ocorreu em 22 casos (57,8%). O defeito ósseo médio pré-operatório da glenóide foi de 22,8% no grupo A e de 13,4% no grupo B (p = 0.0075). A média de idade dos casos em ambos os grupos não apresentou diferença estatística. Tabagismo também não esteve relacionado com diferenças no resultado. Não houve correlação entre a presença de osteólise e o arco de movimento, dor ou ao escore de Rowe. Não houve casos de reluxação; entretanto, quatro pacientes apresentaram apreensão anterior no exame físico.
Conclusão A reabsorção do processo coracoide ocorreu em pelo menos 50% dos pacientes submetidos à cirurgia de Latarjet, e a ausência pré-operatória de perda óssea significativa da glenóide foi o único fator de risco associado a osteólise mais severa do enxerto, porém sem influência no resultado clínico.
Normal Hearing Function in Children Prenatally Exposed to Zika Virus
Authors: Barbosa Maria Helena Magalhães , Garcia Cristiane Fregonesi Dutra , Magalhães Barbosa Maria Clara de , Robaina Jaqueline Rodrigues , Prata-Barbosa Arnaldo , Lima Marco Antonio de Melo Tavares de , Cunha Antonio José Ledo Alves da 
Published: December 2019

Abstract
Introduction The association between prenatal Zika virus infection and hearing alterations in offspring has been the object of some studies, although few have assessed children without microcephaly. However, a current trend to include prenatal Zika virus exposure in the group of risk indicators for hearing loss is noted.
Objective To present a series of 27 children prenatally exposed to the Zika virus submitted to multiple hearing assessments over time.
Methods A cohort of children born to symptomatic mothers with laboratorial Zika virus infection confirmation during pregnancy was submitted to an otoacoustic emission test, auditory brainstem response test (automated, neurodiagnostic and frequency-specific), audiometry, and imitanciometry over a period of 36 months since birth. The hearing assessment was performed independently of the presence of microcephaly or other apparent signs of congenital Zika syndrome.
Results The hearing tests presented predominantly normal results. Some children had signs of middle ear pathology. The only microcephalic child had normal electrophysiological tests, as well as preserved audiometric thresholds, but presented altered motor responses to sound.
Conclusion Prenatal exposure to Zika virus does not always determine hearing impairment. This risk seems to be more associated to the severity of the central nervous system damage. Hearing screening and follow-ups of the affected children are important, as well as further research in this area.
The Outcome of Unilateral Cochlear Implantation in Adults: Speech Recognition, Health-Related Quality of Life and Level of Anxiety and Depression: a One- and Three-Year Follow-Up Study
Authors: Bergman Pia , Lyxell Björn , Harder Henrik , Mäki-Torkko Elina 
Published: December 2019

Abstract
Introduction Hearing impairment is a common disease worldwide, with a comprehensive impact, and cochlear implantation (CI) is an intervention for profound hearing impairment.
Objective To study the outcome one and three years after unilateral CI on hearing, health-related quality of life and level of depression and anxiety, and the correlation between the outcomes. Second, to study whether age, gender, etiology, operated side, residual hearing or cognitive performance can predict the outcome.
Methods A prospective longitudinal study including adults with profound postlingual hearing impairment, with respect to hearing (speech recognition), health-related quality of life (Health Utilities Index 3) and level of depression and anxiety (Hospital Anxiety and Depression scale), pre-CI, and one and three years post-CI. The total sample was composed of 40 participants (40% of men), with a mean age of 71 years.
Results Speech recognition and the overall health-related quality of life improved one year post-CI (p = 0.000), without correlation (ρ= 0.27), and with no difference three years post-CI. The hearing attribute (in the health-related quality of life instrument) improved one and three years post-CI (p = 0.000). The level of anxiety did not change one and three years post-CI. The level of depression improved one year post-CI (p = 0.036), and deteriorated three years post-CI (p = 0.031). Age, etiology, operated side, residual hearing and cognitive performance did not predict the outcome, but the female gender did significantly improve speech recognition compared with men (p = 0.009).
Conclusion The CI significantly improved speech recognition, health-related quality of life and level of depression one year post-CI without mutual correlation, and women performed significantly better than men. There were no further improvements three years post-CI, apart from the hearing attribute.
Further Evolution of a New Nonbiological Transcatheter Valvular Prosthesis
Authors: Schröter Filip , Hartrumpf Martin , Kuehnel Ralf-Uwe , Ostovar Roya , Albes Johannes M. 
Published: December 2019

Abstract
Background Polymeric heart valves are constructed from flexible synthetic materials, therefore aiming to combine the advantageous hemodynamic of biological and the longevity of mechanical valve prostheses. One such valve prototype in development is the PIZZA valve constructed of flexible triangular silicone leaflets on a foldable metal base for perspective transcatheter implantation. Here we present further improvements in its performance through structural modifications.
Methods Structurally modified prototypes were constructed from silicone sheets and stainless-steel wires. Their performance was then tested in a hemodynamic testing device of the type HKP 2.0.
Results Shift from a planar to a cone shape as well as overlapping of the leaflets significantly improved the valves performance, reducing regurgitation as well as systolic pressure gradients.
Conclusions The results of the modified prototypes expressed superior performance and represented a step forward on the road to an easily producible, polymeric transcatheter valvular prosthesis.
Utilization of Erythropoietin within the United States Neonatal Intensive Care Units from 2008 to 2017
Authors: Ahmad Kaashif A. , Bennett Monica M. , Juul Sandra E. , Ohls Robin K. , Clark Reese H. , Tolia Veeral N. 
Published: December 2019

AbstractObjective Little data are available regarding erythropoietin (Epo) utilization patterns within neonatal intensive care units (NICUs). We sought to describe the trends in Epo utilization across a large cohort of U.S. NICUs.Study Design This is a retrospective cohort study of infants discharged from 2008 to 2017 using the Pediatrix Clinical Data Warehouse.Results We identified 704,159 eligible infants from 358 sites, of whom 9,749 (1.4%) had Epo exposure. For extremely low gestational age newborns (ELGANs), Epo exposure ranged from 7.6 to 13.5%. We found significant site variability in Epo utilization in ELGANs. Among the 299 NICUs caring for ELGANs during the study period, 184 (61.5%) never used Epo for this population, whereas 21 (7%) utilized Epo in 50% or more of eligible infants. Epo was initiated at a median of 25 days in ELGANs. For infants with hypoxic–ischemic encephalopathy (HIE), Epo exposure remained ≤1% through 2014 then increased fourfold to 3.4% by 2017. The median day of Epo initiation was the day of birth for infants diagnosed with HIE.Conclusion Epo is utilized in ELGANs more commonly than for other NICU populations. Utilization patterns appear to indicate the treatment of established anemia for ELGANs and more recently for neuroprotection in patients diagnosed with HIE.
Importance of the ultrasound-guided approach for the quadratus lumborum muscle and adjacent structures
Authors: A. Aneiros Zapata , MA Mendoza Rebordinos , A. Benito Domingo 
Published: December 2019

Abstract
Introduction Ultrasound is currently a powerful and valuable tool for assessment purposes and for the performance of invasive procedures during physical therapy treatments, to the extent that this technology is becoming essential for many of these techniques. The evolution undergone by ultrasound-guided techniques in our profession derives in the need to research the importance of the combined use of these two powerful tools.
Aims To demonstrate the importance of ultrasound guidance for the treatment of the quadratus lumborum muscle and adjacent structures.
Material and Methods 20 volunteer subjects were evaluated (seven women and 13 men) aged 22 to 54 years who were asymptomatic. Four freehand approaches were performed (two freehand approaches, one approach on acupuncture point V52 and one approach described by Travell and Simons) and two ultrasound-guided approaches (in prone and in side lying). Each approach was performed twice by the same physical therapist. The freehand approaches were performed by two physical therapists with over five years' experience in invasive physical therapy techniques. The assessment and post-intervention measurements were performed by another physical therapist with over five years' experience in ultrasound assessment and invasive physical therapy techniques. Ultrasound-guided approaches were performed by a physical therapist with over five years' experience in invasive techniques and ultrasound assessment. The data were analyzed with SPSS statistical software for Windows.
Results Statistically significant differences were found between the freehand approaches and ultrasound guided approaches regarding the ability to reach the objective/target tissue (17.5% hit ratios compared to 100%), obtaining a mean distance in the failed attempts of 0.5165cm (0.11-1.61cm). In 70% of the freehand approaches the needle was found in the iliocostal muscle. Overall, during the freehand approaches, and without considering the learning effect, the percentages of hits on the target decreased (from 17.5% to 11.25%) and the percentage needle placements on the iliocostal increased (from 70% to 75%).
Conclusions During physical therapy procedures of the quadratus lumborum muscle and peripheral structures ultrasound-guided approaches are essential to reach the target tissue effectively and with safety.
Ultrasound-Guided percutaneous neuromodulation in non-radiating low back pain
Authors: F. Sanmartin Enriquez , F. Valera Garrido , D. Álvarez Prats , O. Carvajal Fernández 
Published: December 2019

Abstract
Background Low back pain is very common, affecting 15–20% of the population each year, and representing of the main causes of physical therapy consultations. Multiple treatments have been defined for chronic low back pain, however, the findings are still controversial, and therefore new and improved solutions are necessary for the population who suffers from low back pain.
Aims To evaluate the effectiveness of ultrasound-guided percutaneous neuromodulation (US-guided PNM) in patients with non-radiating low back pain.
Material and Methods An experimental study was performed in patients with non-radiating low back pain, between the months of march and may of 2018 at the F&S-Narón Physical Therapy clinic, in A Coruña. Functionality was evaluated via the Oswestry questionnaire and pain was evaluated using the visual analog scale (VAS). US-guided NMP was applied to stimulate the medial branch of a L2 posterior ramus and the iliohypogastric and ilioinguinal nerves, following the protocol described by Valera & Minaya, which consists of the application of a PES type current at 10Hz and 240 microseconds, during 15 seconds and for 6 applications. In total, 3 sessions were applied (sequence 1:7:7), once a week after the first week of initiating treatment.
Results Initially, 12 patients participated in the study, aged between 32 and 59 years. The mean age was 41.4 years. Two of the patients abandoned the study due to personal reasons, unrelated to the research. The final sample consisted of 10 subjects, 50% of each sex. 80% of patients improved after the application of the treatment protocol. An important decrease in activity limitations was observed, from 14 to 4.35 points out of 100 according to the Oswestry questionnaire, and a decrease of 6.8 to 2.15 points out of 10 was observed on the VAS scale, which was statistically significant according to the Wilcoxon test (p < 0,05).
Conclusions The ultrasound-guided percutaneous neuromodulation technique used was effective, obtaining positive results in relation to pain and functionality. Clinical studies are necessary with a greater sample size to confirm these findings.