bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores asociados a la sobrevida en pacientes con tumor de Wilms
Authors: Herrera Toro Natalia , Peña Aguirre Laura , Molina Carlos Federico 
Published: December 2020

Introducción. El tumor de Wilms es el segundo tumor abdominal más frecuente en la edad pediátrica y responde por más del 90 % de los tumores renales en pediatría. A pesar de que la sobrevida descrita es mayor del 90 %, en nuestro medio encontramos que solo alcanza al 70 %, por lo que deseamos evaluar cuáles son los factores asociados con dichos resultados desfavorables, con el fin de implementar medidas para mejorar la sobrevida de nuestros pacientes.
Métodos. Se realizó un estudio observacional, transversal, en dos centros de alto nivel de atención, que incluyó una muestra de 84 pacientes menores de 15 años, con diagnóstico de tumor de Wilms.
Resultados. Los factores que se asociaron significativamente con un aumento en la probabilidad de morir fueron: no completar el protocolo de quimioterapia, (OR 34; IC95% 3,7-312; p 0,000) y presentar recidiva tumoral (OR 35,7; IC95% 6,9-184; p 0,000). Otros factores que aumentaron esta probabilidad sin alcanzar a ser significativos, pero mostrando una evidente tendencia fueron: presentación bilateral (OR 4,1; IC95% 0,6-5,5; p 0,147), complicaciones quirúrgicas (OR 3,2; IC95% 0,7-14,6; p 0,136), compromiso de ganglios linfáticos en tomografía (OR 2,4; IC95% 0,7-8,4; p 0,139) y las metástasis a distancia (OR 2,5; IC95% 0,7-9; p 0,143).
Discusión. La sobrevida de nuestros niños con tumor de Wilms es menor que la reportada en la literatura mundial, siendo la falla en terminar la quimioterapia, la recidiva y la necesidad de cirugía bilateral, los factores asociados con este desenlace.
Controversias en cirugía: Erradicación del Helicobacter pylori ¿Terapia a todos o según indicaciones usuales?
Authors: Isaza-Gómez Esteban , Ángel-González Manuel Santiago , Ocampo-Muñoz Maribel , Díaz-Quintero Camilo Andrés , Molina-Céspedes Isabel Cristina , Velásquez-Martínez María Antonia , Posada-Moreno Pablo , Salazar-Ochoa Santiago 
Published: December 2020

La infección por Helicobacter pylori (H. pylori), es la infección bacteriana crónica más frecuente de la raza humana, afecta al 50 % de la población mundial y, por lo menos, al 80 % de la población colombiana. Esta bacteria es reconocida desde hace más de 15 años como un carcinógeno tipo I. De acuerdo con las indicaciones del Consenso de “Maastricht V” esta infección debe ser buscada y tratada en los pacientes con úlcera péptica activa, Linfoma MALT (por sus siglas en inglés, mucosa associated lymphoid tissue), cáncer gástrico temprano, púrpura que presenten síntomas dispépticos crónicos y usuarios crónicos de AINES.
Debido al papel que tiene en la fisiopatología del cáncer gástrico, nace la iniciativa de realizar una búsqueda activa del H. pylori y erradicarlo en todas las personas, incluyendo aquellas asintomáticas en países con alta incidencia de esta neoplasia.
Existen diversas publicaciones alrededor del mundo que así lo sugieren, mostrando resultados con impacto positivo en el curso y progresión de la enfermedad, sobre todo en las etapas más tempranas de la infección.
Sin embargo, otros autores resaltan la creciente problemática de la resistencia bacteriana, y demuestran que el peso estadístico y los diferentes análisis de los estudios disponibles en la actualidad tienen poca validez para dar una recomendación extendida al paciente asintomático. Se cuestiona que tal vez, estamos utilizando las estrategias inadecuadas para manejar una situación de salud pública, ya que estamos enfocados en impactar a cada individuo con terapias antibióticas complejas, en vez de a la población en general con políticas de salud pública.
MODELING OF CONTROL OF SPEED CONTROL DRIVE AND SLEW MECHANISM DRIVE OF HIGH-SPEED CATERPILLAR VEHICLE WITH BORDER GEARBOX
Authors: Horoshilov Sergey , Kondakov Sergey , Pavlovskaya Ol'ga 
Published: December 2020

The relevance of the topic of investigation is connected with the current trends in gearbox automation and request to lighten slew control of caterpillar vehicles. The purpose set can’t be achieved only in a physical modeling of a drive: the problem is too multiversion and a physical modeling does not guarantee an optimum solution.
The scientific novelty of the investigation consists in the authors’ creation of simulator of gearbox drive and slew mechanism drive consisting of an electromotor, a planetary reducer, a crank mechanism, a hydraulic distributor and hydro-cylinder.
As a consequence, there is realized a parametric investigation possibility of drive numerous parameter impact upon its performance characteristics. By means of the mathematical modeling the drive parameters ensuring the fulfillment of the requirements specification are substantiated.
In the second part of the paper there are shown modeling results of caterpillar vehicle acceleration in a low and the fourth gears and a slew at a speed of 5 m/sec. The result comparison of mathematical modeling and experimental investigations is carried out. The data of experiments, in which took part the authors of the paper, confirm completely the adequacy of the simulator developed. In such a way, the simulator of caterpillar vehicle motion is supplemented with the reliable model of a gearbox drive and a slew mechanism drive in machinery with the border gearboxes. The paper material is used in the design of a similar drive of a new machine.
ANALYSIS OF IMPLEMENTATION WORK FROM HOME ON EMPLOYEES MENTAL WORKLOAD IN CUSTOMS AND EXCISE MAJOR SERVICING OFFICE TYPE A TANJUNG PRIOK
Authors: Gautama Bryan Habib , Fadhilah Indira Dian , Wibowo Agung 
Published: December 2020

ABSTRACT:The purpose of this research is to analyze the implementation of Work From Home (WFH) on the mental workload of employees. The mental workload values were analyzed using the NASA-TLX method. This method measures 6 aspects that affect on mental workload, namely Mental Demand, Physical Demand, Temporal Demand, Performance, Effort and Frustration Level. Researchers conducted different tests on two working conditions, namely normal working/Work From Office (WFO) and Work From Home (WFH). Based on the test results with the Wilcoxon Signed Rank Test, the p value is 0.00 which is smaller than the alpha of 5%. This shows that there is a difference in the mental workload of employees after the implementation of WFH. In addition, the mental workload condition at the Customs and Excise Major Service Office Type A of Tanjung Priok after the implementation of WFH shows a decrease in the average mental workload value of employees by 9.49%.Keywords: Mental Workload, Work From Office, Work From Home, NASA-TLX, Difference Test.ABSTRAK:Penelitian ini bertujuan untuk menganalisis pemberlakuan Work From Home (WFH) terhadap beban kerja mental pegawai. Nilai beban kerja mental dianalisis menggunakan metode NASA-TLX. Metode ini mengukur 6 aspek yang mempengaruhi beban kerja mental yaitu Mental Demand, Physical Demand, Temporal Demand, Performance, Effort, dan Frustration Level. Peneliti melakukan uji beda terhadap dua kondisi kerja yaitu kerja normal/Work From Office (WFO) dan Work From Home (WFH). Berdasarkan hasil pengujian dengan Wilcoxon Signed Rank Test, diperoleh nilai p value sebesar 0.00 lebih kecil dibandingkan alfa sebesar 5%. Hal ini menunjukkan bahwa ada perbedaan beban kerja mental pegawai setelah pemberlakuan WFH. Selain itu, kondisi beban kerja mental pada Kantor Pelayanan Utama Bea dan Cukai Tipe A Tanjung Priok setelah pemberlakuan WFH menunjukkan penurunan nilai rata-rata beban kerja mental pegawai sebesar 9,49%.Kata Kunci: Beban Kerja Mental, Work From Office, Work From Home, NASA-TLX, Uji Beda.
POSTBIOTIC AND OTHER PROTECTIVE MOLECULES RECOGNIZING AND BINDING GLYCOCONJUGATES IN MUCOSAL ORGANS
Authors: Lakhtin V. , Lakhtin M. , Davydkin V. , Melikhova A. , Davydkin I. , Zhilenkova O. 
Published: December 2020

New aspects of human mucosal cavity protection systems are under consideration. On the basis of own data it was suggested that mucosal cavities function as mucosal organs. New players of mucosal organ were proposed. They included system probiotic lectins and probiotic microorganisms, and system synthetic polymeric multivalence pattern glycoconjugates. Lectins and glycoconjugates (mucin-like or imitating, antigens, polysaccharides and other high molecular mass metabolites and postbiotics) were suggested to communicate to other glycoconjugates-recognizing molecules and receptors of the human higher hierarchic protection systems.
Concept of functioning mucosal organs is supported by own proposals, strategies, approaches, methods and algorithms. The data are useful for constructing biotope ordered pro/synbiotic microbiocenoses for application in medical biotechnology.
Internal dose escalation associated with increased local control for melanoma brain metastases treated with stereotactic radiosurgery
Authors: Kennedy William R. , DeWees Todd A. , Acharya Sahaja , Mahmood Mustafaa , Knutson Nels C. , Goddu S. Murty , Kavanaugh James A. , Mitchell Timothy J. , Rich Keith M. , Kim Albert H. , Leuthardt Eric C. , Dowling Joshua L. , Dunn Gavin P. , Chicoine Michael R. , Perkins Stephanie M. , Huang Jiayi , Tsien Christina I. , Robinson Clifford G. , Abraham Christopher D. 
Published: December 2020

OBJECTIVE
The internal high-dose volume varies widely for a given prescribed dose during stereotactic radiosurgery (SRS) to treat brain metastases (BMs). This may be altered during treatment planning, and the authors have previously shown that this improves local control (LC) for non–small cell lung cancer BMs without increasing toxicity. Here, they seek to identify potentially actionable dosimetric predictors of LC after SRS for melanoma BM.

METHODS
The records of patients with unresected melanoma BM treated with single-fraction Gamma Knife RS between 2006 and 2017 were reviewed. LC was assessed on a per-lesion basis, defined as stability or a decrease in lesion size. Outcome-oriented approaches were utilized to determine optimal dichotomization for dosimetric variables relative to LC. Univariable and multivariable Cox regression analysis was implemented to evaluate the impact of collected parameters on LC.

RESULTS
Two hundred eighty-seven melanoma BMs in 79 patients were identified. The median age was 56 years (range 31–86 years). The median follow-up was 7.6 months (range 0.5–81.6 months), and the median survival was 9.3 months (range 1.3–81.6 months). Lesions were optimally stratified by volume receiving at least 30 Gy (V30) greater than or equal to versus less than 25%. V30 was ≥ and < 25% in 147 and 140 lesions, respectively. For all patients, 1-year LC was 83% versus 66% for V30 ≥ and < 25%, respectively (p = 0.001). Stratifying by volume, lesions 2 cm or less (n = 215) had 1-year LC of 82% versus 70% (p = 0.013) for V30 ≥ and < 25%, respectively. Lesions > 2 to 3 cm (n = 32) had 1-year LC of 100% versus 43% (p = 0.214) for V30 ≥ and < 25%, respectively. V30 was still predictive of LC even after controlling for the use of immunotherapy and targeted therapy. Radionecrosis occurred in 2.8% of lesions and was not significantly associated with V30.

CONCLUSIONS
For a given prescription dose, an increased internal high-dose volume, as indicated by measures such as V30 ≥ 25%, is associated with improved LC but not increased toxicity in single-fraction SRS for melanoma BM. Internal dose escalation is an independent predictor of improved LC even in patients receiving immunotherapy and/or targeted therapy. This represents a dosimetric parameter that is actionable at the time of treatment planning and warrants further evaluation.
Efficacy of decitabine in malignant meningioma cells: relation to promoter demethylation of distinct tumor suppressor and oncogenes and independence from TERT
Authors: Stögbauer Louise , Thomas Christian , Wagner Andrea , Warneke Nils , Bunk Eva Christine , Grauer Oliver , Canisius Julian , Paulus Werner , Stummer Walter , Senner Volker , Brokinkel Benjamin 
Published: December 2020

OBJECTIVE
Chemotherapeutic options for meningiomas refractory to surgery or irradiation are largely unknown. Human telomerase reverse transcriptase (hTERT) promoter methylation with subsequent TERT expression and telomerase activity, key features in oncogenesis, are found in most high-grade meningiomas. Therefore, the authors investigated the impact of the demethylating agent decitabine (5-aza-2′-deoxycytidine) on survival and DNA methylation in meningioma cells.

METHODS
hTERT promoter methylation, telomerase activity, TERT expression, and cell viability and proliferation were investigated prior to and after incubation with decitabine in two benign (HBL-52 and Ben-Men 1) and one malignant (IOMM-Lee) meningioma cell line. The global effects of decitabine on DNA methylation were additionally explored with DNA methylation profiling.

RESULTS
High levels of TERT expression, telomerase activity, and hTERT promoter methylation were found in IOMM-Lee and Ben-Men 1 but not in HBL-52 cells. Decitabine induced a dose-dependent significant decrease of proliferation and viability after incubation with doses from 1 to 10 μM in IOMM-Lee but not in HBL-52 or Ben-Men 1 cells. However, effects in IOMM-Lee cells were not related to TERT expression, telomerase activity, or hTERT promoter methylation. Genome-wide methylation analyses revealed distinct demethylation of 14 DNA regions after drug administration in the decitabine-sensitive IOMM-Lee but not in the decitabine-resistant HBL-52 cells. Differentially methylated regions covered promoter regions of 11 genes, including several oncogenes and tumor suppressor genes that to the authors' knowledge have not yet been described in meningiomas.

CONCLUSIONS
Decitabine decreases proliferation and viability in high-grade but not in benign meningioma cell lines. The effects of decitabine are TERT independent but related to DNA methylation changes of promoters of distinct tumor suppressor genes and oncogenes.
Optimal access route for pontine cavernous malformation resection with preservation of abducens and facial nerve function
Authors: Bertalanffy Helmut , Ichimura Shinya , Kar Souvik , Tsuji Yoshihito , Huang Caiquan 
Published: December 2020

OBJECTIVE
The aim of this study was to analyze the differences between posterolateral and posteromedial approaches to pontine cavernous malformations (PCMs) in order to verify the hypothesis that a posterolateral approach is more favorable with regard to preservation of abducens and facial nerve function.

METHODS
The authors conducted a retrospective analysis of 135 consecutive patients who underwent microsurgical resection of a PCM. The vascular lesions were first classified in a blinded fashion into 4 categories according to the possible or only reasonable surgical access route. In a second step, the lesions were assessed according to which approach was performed and different patient groups and subgroups were determined. In a third step, the modified Rankin Scale score and the rates of permanent postoperative abducens and facial nerve palsies were assessed.

RESULTS
The largest group in this series comprised 77 patients. Their pontine lesion was eligible for resection from either a posterolateral or posteromedial approach, in contrast to the remaining 3 patient groups in which the lesion location already had dictated a specific surgical approach. Fifty-four of these 77 individuals underwent surgery via a posterolateral approach and 23 via a posteromedial approach. When comparing these 2 patient subgroups, there was a statistically significant difference between postoperative rates of permanent abducens (3.7% vs 21.7%) and facial (1.9% vs 21.7%) nerve palsies. In the entire patient population, the abducens and facial nerve deficit rates were 5.9% and 5.2%, respectively, and the modified Rankin Scale score significantly decreased from 1.6 ± 1.1 preoperatively to 1.0 ± 1.1 at follow-up.

CONCLUSIONS
The authors' results suggest favoring a posterolateral over a posteromedial access route to PCMs in patients in whom a lesion is encountered that can be removed via either surgical approach. In the present series, the authors have found such a constellation in 57% of all patients. This retrospective analysis confirms their hypothesis in a large patient cohort. Additionally, the authors demonstrated that 4 types of PCMs can be distinguished by preoperatively evaluating whether only one reasonable or two alternative surgical approaches are available to access a specific lesion. The rates of postoperative sixth and seventh nerve palsies in this series are substantially lower than those in the majority of other published reports.
Holmes tremor: a delayed complication after resection of brainstem cavernomas
Authors: Cenzato Marco , Colistra Davide , Iacopino Giorgia , Raftopoulos Christian , Sure Ulrich , Tatagiba Marcos , Spetzler Robert F. , Konovalov Alexander N. , Smolanka Andriy , Smolanka Volodymir , Stefini Roberto , Bortolotti Carlo , Ferroli Paolo , Pinna Giampietro , Franzini Angelo , Dammann Philipp , Naros Georgios , Boeris Davide , Mantovani Paolo , Lizio Domenico , Piano Mariangela , Fava Enrica 
Published: December 2020

OBJECTIVE
In this paper, the authors aimed to illustrate how Holmes tremor (HT) can occur as a delayed complication after brainstem cavernoma resection despite strict adherence to the safe entry zones (SEZs).

METHODS
After operating on 2 patients with brainstem cavernoma at the Great Metropolitan Hospital Niguarda in Milan and noticing a similar pathological pattern postoperatively, the authors asked 10 different neurosurgery centers around the world to identify similar cases, and a total of 20 were gathered from among 1274 cases of brainstem cavernomas. They evaluated the tremor, cavernoma location, surgical approach, and SEZ for every case. For the 2 cases at their center, they also performed electromyographic and accelerometric recordings of the tremor and evaluated the post-operative tractographic representation of the neuronal pathways involved in the tremorigenesis. After gathering data on all 1274 brainstem cavernomas, they performed a statistical analysis to determine if the location of the cavernoma is a potential predicting factor for the onset of HT.

RESULTS
From the analysis of all 20 cases with HT, it emerged that this highly debilitating tremor can occur as a delayed complication in patients whose postoperative clinical course has been excellent and in whom surgical access has strictly adhered to the SEZs. Three of the patients were subsequently effectively treated with deep brain stimulation (DBS), which resulted in complete or almost complete tremor regression. From the statistical analysis of all 1274 brainstem cavernomas, it was determined that a cavernoma location in the midbrain was significantly associated with the onset of HT (p < 0.0005).

CONCLUSIONS
Despite strict adherence to SEZs, the use of intraoperative neurophysiological monitoring, and the immediate success of a resective surgery, HT, a severe neurological disorder, can occur as a delayed complication after resection of brainstem cavernomas. A cavernoma location in the midbrain is a significant predictive factor for the onset of HT. Further anatomical and neurophysiological studies will be necessary to find clues to prevent this complication.
Intracranial EEG and laser interstitial thermal therapy in MRI-negative insular and/or cingulate epilepsy: case series
Authors: Gireesh Elakkat D. , Lee Kihyeong , Skinner Holly , Seo Joohee , Chen Po-Ching , Westerveld Michael , Beegle Richard D. , Castillo Eduardo , Baumgartner James 
Published: December 2020

OBJECTIVE
The goal of this study was to assess the success rate and complications of stereo-electroencephalogra-phy (sEEG) and laser interstitial thermal therapy (LITT) in the treatment of nonlesional refractory epilepsy in cingulate and insular cortex.

METHODS
The authors retrospectively analyzed the treatment response in 9 successive patients who underwent insular or cingulate LITT for nonlesional refractory epilepsy at their center between 2011 and 2019. Localization of seizures was based on inpatient video-EEG monitoring, neuropsychological testing, 3-T MRI, PET scan, magnetoencephalography scan, and/or ictal SPECT scan. Eight patients underwent sEEG, and 1 patient had implantation of both sEEG electrodes and subdural grids for localization of epileptogenic zones. LITT was performed in 5 insular cases (4 left and 1 right) and 3 cingulate cases (all left-sided). One patient also underwent both insular and cingulate LITT on the left side. All of the patients who underwent insular LITT as well as 2 of the 3 who underwent cingulate LITT were right-hand dominant. The patient who underwent insular plus cingulate LITT was also right-hand dominant.

RESULTS
Following LITT, 67% of the patients were seizure free (Engel class I) at follow-up (mean 1.35 years, range 0.6–2.8 years). All patients responded favorably to treatment (Engel class I–III). Two patients developed small intracranial hemorrhages during the sEEG implantation that did not require surgical management. One patient developed a large intracranial hemorrhage during an insular LITT procedure that did require surgical management. That patient experienced aphasia, incoordination, and hemiparesis, which resolved with inpatient rehabilitation. No permanent neurological deficits were noted in any of the patients at last follow-up. Neuropsychological status was stable in this cohort before and after LITT.

CONCLUSIONS
sEEG can be safely used to localize seizures originating from insular and cingulate cortex. LITT can successfully treat seizures arising from these deep-seated structures. The insula and cingulum should be evaluated more frequently for seizure onset zones.
MENINKATKAN PROSES DAN HASIL BELAJAR IPA MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE STAD DI KELAS VIII SMPN 1 PUJUT
Authors: Lahim Lahim 
Published: December 2020

Abstrak: Dilaksanakan Penelitian Tindakan Kelas dalam tiga siklus dengan tujuan mendeskripsikan peningkatan hasil dan proses pembelajaran pada siswa kelas VIII SMPN 1 Pujut Tahun 2014/2015. Data yang dianalisis berupa data observasi aktivitas, quisioner, dan tes hasil belajar. Hasil aktivitas siswa kategori sangat aktif: 23,3 siklus I, 23,2 siklus II, dan 24,2 siklus III. Aktivitas guru kategori sangat aktif rata-rata 14 pada ketiga siklus. Ketuntasan klasikal aspek kognitif 74% pada siklus I, 83% pada siklus 2, dan 91 % pada siklus 3. Disimpulkan bahwa penerapan model pembelajaran kooperatif tipe STAD dapat meningkatkan proses dan hasil belajar belajar kelas VIII SMPN 1 Pujut tahun Pelajaran 2014/2015.Abstract: Classroom Action Research was conducted in three cycles with the aim of describing the improvement of results and learning process in the students of grade VIII SMPN 1 Pujut Year 2014/2015. The data were analyzed in the form of activity observation data, quisioner, and test of learning result. The results of student activity categories are very active: 23.3 cycles I, 23.2 cycles II, and 24.2 cycles III. Activity teacher category is very active on average 14 on the third cycle. Classical completeness of cognitive aspect 74% in cycle I, 83% in cycle 2, and 91% in cycle 3. It is concluded that the application of STAD type cooperative learning model can improve the process and learning outcomes of class VIII SMPN 1 Pujut Lesson 2014/2015.