bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventricular expansion, white matter hyperintensities, and global cognition in Alzheimer’s disease and normal aging
Authors: Adamo Sabrina , Ramirez Joel , Holmes Melissa F. , Gao Fuqiang , Zotovic Ljubica , Masellis Mario , Black Sandra E. 
Published: November 2020

ABSTRACTBackgroundThe progression of Alzheimer’s Disease (AD) may be tracked by measuring the growth of the ventricular cerebrospinal fluid (vCSF) over time. AD is commonly comorbid with markers of cerebral small vessel disease (SVD), viewed on MRI as white matter hyperintensities (WMH). Larger WMH volumes are correlated with poorer cognitive test scores. Additionally, periventricular WMHs have a proposed relationship to the vCSF.PurposeThis study will examine ventricular expansion and its associations between periventricular/deep WMH and cognition in AD and normal aging.MethodsBaseline and 1-year follow-up data were collected from AD (n=117) and cognitively normal control (NCs; n=49) participants taking part in the Sunnybrook Dementia Study. MRI (1.5T) and scores from both the Mini-Mental State Examination (MMSE) and the Dementia Rating Scale (DRS) were assessed at each time point. Volumetric data was generated using a semi-automated pipeline and each individual’s vCSF and WMHs were transformed to an intermediate space to determine volumetric growth. Regressions were used to determine relationships between vCSF growth measures, SVD burden, and cognition, accounting for demographics and individual interscan intervals.ResultsThe AD group displayed 14.6% annual ventricular growth as opposed to NC who had only 11.8% annual growth. AD showed significant growth in vCSF (p < 0.001), a trend toward greater pWMH growth (p = 0.06) and no difference in dWMH growth volumes compared to NC. vCSF growth was positively associated with pWMH (β = 0.32, p < 0.001) but not dWMH growth in AD while in NC it was associated with both pWMH (β = 0.48, p < 0.001) and dWMH growth (β = 0.35, p = 0.02). In AD, vCSF growth was associated with the both the MMSE (β = -0.30, p < 0.001) and the DRS (β = -0.31, p < 0.001) in separate models.ConclusionsThe findings from this study suggest that in just under 1.5 years, the significantly rapid ventricular expansion observed in AD may be closely related to periventricular small vessel disease. As vCSF growth rates are an important biomarker of AD neurodegeneration that corresponds with cognitive decline, future research should further explore atrophy associated with periventricular vasculopathy.Trial RegistrationClinicalTrials.gov, NCT01800214. Registered on 27 February 2013.
The molecular logic of synaptic wiring at the single cell level
Authors: Velten Jessica , Agarwal Rashi , van Nierop Patrick , Domsch Katrin , Bognar Lena , Paulsen Malte , Velten Lars , Lohmann Ingrid 
Published: November 2020

SUMMARYThe correct wiring of neuronal circuits is one of the most complex processes in development, since axons form highly specific connections out of a vast number of possibilities. Circuit structure is genetically determined in vertebrates and invertebrates, but the mechanism guiding each axon to precisely innervate a unique pre-specified target cell is poorly understood. Here, we used single cell genomics, imaging and genetics to show that single-cell specific connections between motoneurons and target muscles are specified through a combinatorial code of immunoglobulin domain proteins. These programs are orchestrated by a homeodomain transcription factor code that specifies cellular identities down to the level of biologically unique cells. Using spatial mapping, we show that this code follows spatial patterns already observed at early embryonic stages, while acting at a much later stage to specify motor circuits. Taken together, our data suggest that a relatively simple homeo-immunoglobulin-code determines neuronal circuit structure.
Measuring consumer perceptions over beef good practices and sustainable production process
Authors: Burnier Pedro Carvalho , Guerra Diego de Sousa , Spers Eduardo Eugênio 
Published: November 2020

PurposeInformation on scales for measuring dimensions related to consumer concerns over production processes is scarce in the literature. The purpose of this study was to develop a more comprehensive scale for measuring concern over the production process (CPP).Design/methodology/approachThe authors derive the concept based on the results of a bibliographic review, existing certification criteria, an interview with five experts and two consumer focus groups. The authors interviewed 725 frequent beef meat consumers to test the scale.FindingsStatistical tests and purification yielded a final scale with 18 items and six latent variables: animal welfare, traceability, social responsibility, environmental responsibility, legality and sanitation in slaughterhouses. The authors confirmed the nomological validity of the instrument using product involvement as an antecedent construct and attitude related to sustainable consumption as a consequent of CPP.Research limitations/implicationsThe research results may lack generalisability. New research avenues are suggested for testing the scale in other cultural contexts and with different groups of consumers and food types.Practical implicationsThis study provides insights for cattle ranchers, the industry and the retail sector in formulating communication strategies and product/brand positioning in response to consumer concerns about the production process.Originality/valueThere is no study at present that fully addresses the use of a scale to measure dimensions of production processes. The creation of the CPP scale is a relevant academic contribution that aids in assessing the influence of the environmental dimension in conjunction with other essential constructs.
Somatotype identification of middle-aged women based on decision tree algorithm
Authors: Wang Lanmin , Wang Hongmin , Zhang Huiyan , Akemujiang Naiseman , Xiao Aimin 
Published: November 2020

PurposeBody type classification has a great influence on plate making and garment sizing system, and the accuracy of body type classification method will greatly affect the fit of garment production. The purpose of this paper is to use the decision tree algorithm to study body classification rules, develop a decision tree body recognition model and judge the body shape of middle-aged women in Xinjiang.Design/methodology/approachFirst, perform dimensionless processing on the collected data of 256 middle-aged women in Xinjiang, and the dimensionless data were used for K-means body clustering; Then, quantitatively analyze the effectiveness of different classification clusters based on the silhouette coefficients. Second, the decision tree algorithm is used to divide the classified sample data into a training set and a test set at a ratio of 70/30, and select the best node and the best branch based on the Gini coefficient to construct a classification tree. Last, the overall optimal decision tree is generated by means of hyperparameter pruning.FindingsThe body shape of middle-aged women in Xinjiang can be divided into three types: standard body, plump body and obese body. The decision tree model has an excellent effect on body classification of middle-aged women in Xinjiang (precision (macro), 95.46%; precision (micro), 95.95%; recall (macro), 95.46%; recall (micro), 95.95%; F1 (macro), 95.46%; F1 (micro), 95.95%).Originality/valueFor scientific research, this paper is conducive to increasing the regional body type theory and stimulating the establishment of a garment sizing subdivision system in Xinjiang. In terms of production practice, this paper not only establishes a model for judging the shape of middle-aged women in Xinjiang, but also provides reference data for intermediates of various sizes. In addition, to facilitate pattern-making and the establishment of a subdivision system for the size of middle-aged women's garments in Xinjiang, this paper provides the grading values of various body control parts of middle-aged women in Xinjiang.
Leveraging knowledge sharing and innovation culture into SMEs sustainable competitive advantage
Authors: Arsawan I Wayan Edi , Koval Viktor , Rajiani Ismi , Rustiarini Ni Wayan , Supartha Wayan Gede , Suryantini Ni Putu Santi 
Published: November 2020

PurposeThis study aimed to examine and explain the role of knowledge sharing in shaping innovation culture to improve business performance and build sustainable competitive advantage. Most empirical research tended to be conducted in large companies, and there are limited studies on this topic in the SME sector. Thus, the study needs to re-examine whether the theories developed to understand large companies apply to SMEs.Design/methodology/approachThis quantitative study involved 259 respondents from a 59 sampling frame consisting of three levels of management of export SMEs in the Bali province of Indonesia. The questionnaire used to gather the data used a semantic differential scale, and the data were analyzed using SmartPLS software.FindingsThe results showed that knowledge sharing significantly influenced innovation culture, business performance and sustainable competitive advantage. Theoretically, this research provides insight into the body of knowledge in innovation culture and business performance as a mediator variable.Research limitations/implicationsCross-sectional design limits the authors from drawing definitive generalizations, and self-reported measures used in the study increase the chances of bias.Practical implicationsThe study's findings could motivate managers and practitioners to place emphasis on knowledge sharing and innovation culture in the SME sector.Originality/valueThe role of knowledge sharing has been focused on large companies in several countries. However, research examining the role of knowledge sharing in building an innovation culture is still rare in the SME sector, particularly in Indonesian SMEs. Therefore, research on this topic is needed because Indonesia has not only a different culture but also different business practices.
Attitudes towards offenders with intellectual disability
Authors: Worthington Rachel , Rossetti Sarah 
Published: November 2020

Purpose
Public attitudes are considered influential in the successful reintegration of offenders into society after release, however research into attitudes towards offenders with intellectual disability (ID) has received little attention. The purpose of this study is firstly to see if people hold differing attitudes towards the reintegration of offenders with ID compared to those without ID and secondly, to investigate whether this difference in attitude is because of differing implicit theories of intelligence (TOI). The effects of familiarity with ID were also measured.

Design/methodology/approach
In total, 200 participants read crime vignettes depicting crimes committed by offenders with and without ID and completed Dweck’s “TOI” scale.

Findings
Participants were found to have greater entity views of intelligence towards ID yet displayed more positive attitudes towards their reintegration than offenders without ID. The influence of demographics was mixed. It would appear attitudes towards offenders with ID are not as negative as initially thought.

Research limitations/implications
Implications of these findings are discussed in terms of desistance and community integration.

Practical implications
While some care must be taken when interpreting the results, this study demonstrates positive results regarding the reintegration of offenders with ID. Attitudes may be changing for the better towards those with disabilities, which is positive in terms of the government and National Health Service (NHS) objectives to reintegrate people with ID successfully back into the community. Although limited in number, it is noted that community forensic mental health teams have been effective in managing offender risk and providing good quality care (Dinani,et al.,2010; Benton and Roy, 2008). They can provide more person-centred and specialist treatments options and have links with other community services, probation and the police (Royal College of Psychiatrists, 2014).

Social implications
Community care is thought to lead to more timely treatments with more accessible support teams and services that those with ID would struggle to access in prison (Bradley, 2009). It can also lead to greater well-being and support as individuals are in a less restrictive environment and are closer to their social networks, acting as a protective factor against further reoffending (Benton & Roy, 2008; Bradley, 2009). Furthermore, it has been indicated significant financial savings would be achieved for the criminal justice system by reducing inpatient care and increasing community services and sentences, in addition to reducing the demand on prison spaces (Bradley, 2009; Benton & Roy, 2008).

Originality/value
To date, very few studies have used TOI to examine attitudes towards offenders, with none examining attitudes towards offenders with ID.
Factors associated with electronic cigarettes use among adolescents in Jakarta, Indonesia
Authors: Fauzi Ridhwan , Areesantichai Chitlada 
Published: November 2020

PurposeThis study aimed to examine factors associated with electronic cigarette use among adolescents aged 15–19 in Jakarta, Indonesia.Design/methodology/approachThe study was a school-based survey involving 1,318 students from 14 high schools in Jakarta. A multistage cluster sampling methodology was used. The authors used the chi-square test and multiple logistic regression to examine the association between electronic cigarette use and sociodemographic, social influences, health risk perceptions, availability, affordability and conventional cigarette smoking status.FindingsOverall, 6.3% of females and 29% of males reported ever having used electronic cigarettes. Electronic cigarette use was independently associated with sex, school locations, conventional cigarette smoking status, peer use, availability and perceptions that electronic cigarettes aid conventional cigarette smoking cessation. Compared with non-smokers, lifetime (AOR: 8.740, 95% CI: 5.126–14.901) and current conventional cigarette smokers (AOR: 18.380, 95% CI: 10.577–31.938) were more likely to use electronic cigarettes.Social implicationsThe use of electronic cigarettes among adolescents was considerably high in this study. Therefore, the tobacco control policy should be extended to regulate the marketing and use of all types of tobacco products and not just conventional cigarettes.Originality/valueThe study explored beyond individual lifestyle factors that contributed to electronic cigarette use in Indonesia such as affordability, school locations and availability of electronic cigarettes. These issues have not been specifically discussed in previous studies.
Experiencing workplace ostracism with loss of engagement
Authors: Xu Xiaofeng , Kwan Ho Kwong , Li Miaomiao 
Published: November 2020

PurposeDrawing on social exchange theory and a cultural perspective, this study examines the relationship between workplace ostracism and job engagement by focusing on the mediating role of felt obligation and the moderating role of collectivism.Design/methodology/approachA two-wave survey was conducted over four months in a private service business in China. The participants comprised 108 Chinese employees.FindingsThe results indicate that workplace ostracism has a negative relationship with job engagement through a reduced sense of felt obligation. Collectivism strengthens the main effect of workplace ostracism on felt obligation and its indirect effect on job engagement via felt obligation.Research limitations/implicationsThis study contributes to understanding of the internal mechanism of the workplace ostracism–job engagement model by identifying the mediating role of felt obligation. It also emphasizes that collectivist cultures can enhance the effects of workplace ostracism. However, the generalizability of our findings may be limited due to this cultural factor.Practical implicationsOur findings show that workplace ostracism plays a significant role in reducing job engagement. Therefore, it is essential to reduce the incidence of ostracism in the workplace.Originality/valueBy addressing the previously unexplored mechanism that mediates the relationship between workplace ostracism and job engagement, this study provides new directions for research on workplace ostracism and job engagement.
Moving towards healthy: cuing food healthiness and appeal
Authors: Amar Moty , Gvili Yaniv , Tal Aner 
Published: November 2020

Purpose
This paper aims to offer social marketers an innovative method to promote healthy foods. This method demonstrates the effectiveness of indirect communication in attracting consumers to healthy foods. Further, it aims to offer a way to promote food as healthier with no detrimental effects on its perceived appeal, which are a likely side effect of advertising food as healthy.

Design/methodology/approach
Four between-participant lab studies (N = 50, 80, 80, 102) included manipulations of food motion vs stillness and then compared ratings of food freshness, healthiness and appeal using self-report measures.

Findings
Motion increases healthiness evaluation. This increase in healthiness evaluation occurs without reductions in food appeal. These effects are mediated by evaluations of freshness. This occurred across three different food types and two mediums (still images and digital videos).

Research limitations/implications
The paper provides an effective tool for social marketers wishing to encourage healthier eating. Specifically, it helps address two problems: low effectiveness of prevalent, information-based appeals to encourage healthy eating; and reduced evaluations of tastiness that normally occur when consumers are convinced food is healthy.

Social implications
Social marketers can use motion as an effective tool to promote food as healthy. Importantly, this indirect communication avoids the potential pitfall of reduced food appeal. This should help encourage healthier eating. The findings also supports the use of indirect cues as an effective approach to promoting social ends.

Originality/value
Offering a novel, indirect method of enhancing judgments of food healthiness via a simple visual cue. Demonstrating the effect and its underlying mechanism. Providing a way to counter the prevalent “unhealthy = tasty” intuition, a major obstacle to promoting healthy eating. Supporting social marketers’ use of indirect communication to increase the appeal of desirable societal goals. Finally, showing that sensory visual cues can serve as a source of heuristic thinking.
Leadership at Godrej: a treasured heirloom transformed into a valuable brand
Authors: Pattanayak Lopamudra , Jena Lalatendu Kesari , Sahoo Kalpana 
Published: November 2020

Purpose
The purpose of this study is to bring out the success of the Godrej Group, focusing on their leadership styles and discussing how authentic and ethical leadership leads to value-based leadership (VBL), which has its eminence in the post-COVID-19 world.

Design/methodology/approach
The case study has been designed based on secondary published sources and few informal interactions with the leaders associated with the Godrej Group.

Findings
It was found that VBL is derived from authentic and ethical leadership and Adi Godrej, Chairman of Godrej Group, managed to sail through all these years successfully by adopting the authentic, ethical and VBL style, thereby transforming the family business into a global business and a valuable brand.

Originality/value
The case study is based on secondary published sources and informal interactions with the Godrejites. The different elements and eminence of authentic, ethical and VBL styles are explored. These values will play a significant role in the post-COVID-19 world. Value-based leader inculcates a clear, honest, empathetic and simple approach to employer–employee communication as the COVID-19 situation evolves. This case will therefore be of value to anyone using or considering a value-based approach to developing a successful leadership culture. These include Masters of Business Administration students, entrepreneurs, professional practitioners, etc.
MiR‐320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling
Authors: Wang Jianyang , Zhao Hong , Yu Jing , Xu Xin , Jing Hao , Li Ning , Tang Yuan , Wang Shulian , Li Yexiong , Cai Jianqiang , Jin Jing 
Published: November 2020

AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies in the world and is associated with high mortality. Ionizing radiation (IR)‐based therapy causes DNA damage, exerting a curative effect; however, DNA damage repair signaling pathways lead to HCC resistance to IR‐based therapy. RAD21 is a component of the cohesion complex, crucial for chromosome segregation and DNA damage repair, while it is still unclear whether RAD21 is implicated in DNA damage and influences IR sensitivity in HCC. The current research explores the effect and upstream regulatory mechanism of RAD21 on IR sensitivity in HCC. In the present study, RAD21 mRNA and protein expression were increased within HCC tissue samples, particularly within IR‐insensitive HCC tissues. The overexpression of RAD21 partially attenuated the roles of IR in HCC by promoting the viability and suppressing the apoptosis of HCC cells. RAD21 overexpression reduced the culture medium 8‐hydroxy‐2‐deoxyguanosine concentration and decreased the protein levels of γH2AX and ATM, suggesting that RAD21 overexpression attenuated IR treatment‐induced DNA damage to HCC cells. miR‐320b targeted RAD21 3ʹ‐UTR to inhibit RAD21 expression. In HCC tissues, particularly in IR‐insensitive HCC tissues, miR‐320b expression was significantly downregulated. miR‐320b inhibition also attenuated IR treatment‐induced DNA damage to HCC cells; more importantly, RAD21 silencing significantly attenuated the effects of miR‐320b inhibition on IR treatment‐induced DNA damage, suggesting that miR‐320b plays a role through targeting RAD21. In conclusion, an miR‐320b/RAD21 axis modulating HCC sensitivity to IR treatment through acting on IR‐induced DNA damage was demonstrated. The miR‐320b/RAD21 axis could be a novel therapeutic target for further study of HCC sensitivity to IR treatment.
Quality and nutritional characteristics of traditional curd cheese enriched with thermo‐coagulated acid whey protein and indigenous Lactococcus lactis strain
Authors: Mileriene Justina , Serniene Loreta , Kondrotiene Kristina , Lauciene Lina , Kasetiene Neringa , Sekmokiene Dalia , Andruleviciute Vaida , Malakauskas Mindaugas 
Published: November 2020

SummaryConsumer interest in a healthy lifestyle and health‐promoting natural products is a major driving force for the increasing global demand for bio‐functional and sustainable dairy foods. Supplementation of curd cheese with thermo‐coagulated acid whey protein (TAWP) led to 8–10% higher contents of moisture, 23–31% of lactose, 12–13% of unsaturated, 5–6% of monounsaturated, 63% of polyunsaturated, and 3–4% of long‐chain fatty acids. Lipid quality indices – TI, AI, h/H, and Omega 6/3 among others, were also significantly better than those of control cheese. The addition of indigenous Lactococcus lactis strain enhanced the flavour of cheese samples, decreased the counts of yeast and mould up to 1 log cfu g−1 after 10 days of storage. The replacement of curd with TAWP resulted in novel cheese with overall sensory perception above 77 points and added nutritional and functional value, however, body and texture parameters of modified cheese samples require an improvement.