bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zijn boilerplates ter zake van de beperking van het rechterlijk ingrijpen bij dwaling acceptabel?
Authors: van Wechem T.H.M. , Rijsterborgh A.J. 
Published: June 2020

Zijn boilerplates ter zake van de beperking van het rechterlijk ingrijpen bij dwaling acceptabel?
De auteurs onderzoeken de vraag of partijen de rechtsgevolgen van dwaling, voor zover deze betrekking heeft op de wijzigingsbevoegdheid van de rechter op grond van artikel 6:230 lid 2 BW, contractueel regelen; kunnen partijen afstand doen van een rechtsvordering (of verweer) op grond van laatstgenoemd artikel en de rechter op dit punt buitenspel zetten? Alhoewel de Hoge Raad zich nog niet over deze vraag heeft uitgelaten en er goede argumenten voor een ander standpunt zijn, beantwoorden de auteurs de door hen gestelde vraag voorshands ontkennend.
Het non-concurrentiebeding in de franchiseovereenkomst anno 2020
Authors: Kolenbrander J.H. 
Published: June 2020

Het non-concurrentiebeding in de franchiseovereenkomst anno 2020
Deze reeks artikelen betreft een overzicht van jurisprudentie ter zake het postcontractuele non-concurrentiebeding in de franchiseovereenkomst. In deze aflevering komen onder andere de redelijkheid en billijkheid, de pre-emptive strike en betrokken derden aan de orde.
Estrategias discursivas de las instituciones públicas en la web: nuevas formas de comunicar las políticas públicas
Authors: Martínez Romagosa Maite , Zukerfeld Gilda Lucía 
Published: June 2020

Este trabajo se enmarca en un proyecto UBACyT que se propone estudiar las transformaciones en los sistemas semióticos de las prácticas políticas en la Argentina pos 2001.Creemos que el uso de nuevas plataformas para la distribución de información y la interacción entre las instituciones públicas y los ciudadanos ha dado lugar a modificaciones que afectan tanto al funcionamiento de las mismas instituciones como a la constitución de la ciudadanía. Si bien estos cambios han sido estudiados desde otras ciencias sociales, no se ha focalizado en los cambios en el uso lingüístico desde una perspectiva discursiva. En particular, en este trabajo nos interesa indagar en las prácticas comunicacionales de las instituciones gubernamentales, que llamaremos, con algunos autores (Agar, 1985; Iedema, 1998; Wodak, 1997), discurso institucional.Sostenemos que el Análisis del Discurso nos permite acceder a los contenidos de las representaciones sociales (Raiter, 2016) y observar los cambios discursivos y la lucha por la acentuación de los signos (Voloshinov, 2009). Nos interesa en particular estudiar cómo los cambios en los textos y en las prácticas discursivas pueden anticipar cambios en la clasificación de sectores de la sociedad y en las prácticas sociales (Fairclough, 1992).Nuestro corpus de análisis está conformado por las páginas de inicio de dos sitios web que dependen del Gobierno de la Nación Argentina y del Gobierno de la Ciudad de Buenos Aires, respectivamente, en los que se presentan lineamientos de políticas públicas que llaman a la “participación” de la ciudadanía mediante plataformas digitales
Magnitude of Prior Teenage Pregnancy among Women Aged 18–67 Years in Rural Southwestern Uganda
Authors: Mulogo Edgar Mugema , Ntaro Moses , Kenney Jessica , Patel Palka , Wesuta Andrew , Kawungezi Peter Chris , Bwambale Shem , Matte Michael , Bagenda Fred , Stone Geren 
Published: June 2020

Objective: Teenage pregnancy is a growing health challenge among adolescents in Uganda with its magnitude varying across the different regions of Uganda. This study evaluated the magnitude and factors associated with prior teenage pregnancy among women aged 18-67 years in a rural community of Kasese district, Uganda.
Results: Fifty-two percent (52%) of the 138 women interviewed, had a prior teenage pregnancy. Having experienced a teenage pregnancy was independently associated with; occupation of current household heads (adjusted odds ratio, aOR= 0.2, 95% confidence interval, CI: 0.1 – 0.9), whether or not the current household could adequately meet their food needs (aOR= 0.1, 95% CI: 0.01 – 0.8), and whether the current household shared toilet facilities (aOR= 4.7, 95% CI: 1.0 – 21.8).
Conclusion: The findings suggest that magnitude of prior teenage pregnancy among women in this rural community is much higher than the national average. Socio economic factors at household level are contributory to prior teenage pregnancy. A multi sectoral approach integrating household livelihood improvement with health interventions targeting the girl child is proposed to curb teenage pregnancy in this context.
Characterization for Different Traits in Asiatic and European Type Carrot (Daucus carota var. sativa L.) Germplasm Lines
Authors: Singh Davinder , Dhillon Tarsem Singh , Singh Rajinder 
Published: June 2020

The present investigation was carried out to characterize the eighty one carrot genotypes through variability, heritability and genetic gain for different characters. Analysis of variance revealed highly significant differences among the genotypes for all the characters. Genetic variability, heritability and genetic advance were estimated for marketable and its component yield traits in 81 lines of carrot (Daucus carota var. sativa L.). The study showed high ranges for total yield (4.9-9.3 kg plot-1), marketable yield (4.6-9.2 kg plot-1), root length (13.8-30.8 cm) and root weight (101.4-127.2 g). Genotypes PC-161, PC-15, PC-173 (red), PCO-30, PCO-5, PCO-7 (Orange) PCP-2, PCP-1 and PCP-17B (Purple) were superior with respect to total and marketable yield per plot along with various horticultural traits. Magnitude of phenotypic coefficient of variation (PCV) was higher than corresponding genotypic coefficient of variation (GCV) for all the characters which indicated the role of environment on the character expression. Quantitative traits like Anthocyanin content (mg 100 g-1), Total sugar content (%), Carotene content (mg 100g-1) and Dry matter content (%) have higher values of GCV, heritability, genetic advance and genetic gain hence these were the most important traits for applying selection in carrot for crop improvement.
Hydro-geologic, Corrosivity and Geotechnical Implications of Geoelectric Sounding Survey at FUTA Cooperative Housing Estate, Ilaramokin near Akure Southwestern Nigeria
Authors: Adeyemo I. A. , Iwuala V. O. , Fadare T. S. , Otayemi E. O. 
Published: June 2020

Aim: Groundwater potential evaluation, corrosivity and geotechnical competence investigations of the subsurface layers were carried at FUTA Cooperative Housing Estate, Ilaramokin near Akure Southwestern Nigeria in order to facilitate proper positioning of facilities within the estate.
Methodology: A total of 14 vertical electrical sounding (VES) data was acquired across the estate using Schlumberger array.
Results: The VES survey results delineated 3 - 5 geoelectric layers across the estate which corresponds to the topsoil, weathered layer, partially weathered basement, partially fractured basement and the presumed fresh bedrock. The groundwater potential map of the estate revealed that the groundwater potential is moderate (GWP of 0.5 - 0.75) to high (GWP of 0.75 - 1.0) in the western and southeastern parts of the estate. The depth slice corrosivity maps (1.0, 2.0 and 3.0 m) of the estate indicated that the corrosivity of the subsurface layers within the estate reduces with depth. The 0.5 m depth slice isoresistivity map of the estate indicates that the central and a segment of the southwestern parts of the estate are characterized with low resistivity (50 - 100 Ωm) indicating incompetence, while the estate flanks (west and east) are considered to be moderately competent (100 - 350 Ωm). Likewise, the 1.0 m depth slice isoresistivity map of the estate reveals that the central and western parts of the estate are characterized with low resistivity (50 - 100 Ωm) suggesting incompetent layer, while the northern, southern and eastern parts of the estate are moderately competent (100 - 350 Ωm).
Conclusion: These results suggested that structural failures can be expected on any engineering structures sited at the central, northern, southern and eastern parts of the estate. Groundwater efforts should be concentrated at the western and southeastern parts of the estate.
Quality of life and insomnia validation study for a specifically designed questionnaire
Authors: Jambon B , Le Gal M , Pilate C 
Published: July 2002

SummaryA questionnaire was devised to assess changes in the quality of life of insomniac patients when treated by a hypnotic. The questionnaire was validated in two groups of patients (60 non-insomniac and 52 insomniac patients). The results of this study confirmed the relevance of the questionnaire and its power to distinguish between the two groups of patients. A second study carried out simultaneously in 58 insomniac patients receiving treatment showed the internal reliability of the questionnaire and its reproducibility after 3 to 5 days.
Synaptic development in semi‐dissociated cultures of rat retina
Authors: Dhingra Narender K. , Reddy Rajini , Govindaiah  , Hemavathy U. , Raju Trichur R. , Ramamohan Y. 
Published: July 2002

AbstractCultured neurons provide a simpler and more accessible environment to study the synaptic physiology. However, it is not clear if development of synapses in culture is similar to that in the in vivo condition. We studied the developmental sequence and morphological differentiation of chemical synapses in semi‐dissociated rat retinal cultures that consisted of dissociated neurons as well as undissociated retinal aggregates. Synapses were quantified by synaptophysin immunoreactive puncta. During second week of in vitro development the average number of chemical synapses on the cell body decreased while that on the neurites increased significantly. Conventional synapses appeared both in aggregate and in dissociated neurons, with the developmental profile similar to that reported for in vivo retina. In contrast, the development of ribbon synapses was adversely affected by the in vitro microenvironment as suggested by following observations. The ribbon synapses were more frequently found in aggregate than in dissociated neurons, and were not associated with dyadic or triadic synaptic arrangement. The photoreceptor ribbons did not contact a postsynaptic process while bipolar ribbons made single (monadic) synapses. Further, photoreceptor ribbons in dissociated neurons were late to form and took more time to mature as compared to those in the aggregate cultures. Most of the rod bipolar cells, identified by their immunoreactivity to protein kinase C (PKC), had three or more neurites. Unlike in the in vivo retina, the dissociated rod bipolar cells did not show any PKC immunoreactive varicosities, suggesting that they failed to develop a well‐differentiated synaptic terminal. Interestingly, we did not find any parvalbumin positive AII amacrine cells that are normally postsynaptic to rod bipolar cells. These results show that the conventional synapses of retina, which are similar to chemical synapses in other parts of the brain, develop normally both in aggregate and dissociated neurons. However, the highly specialized ribbon synapses have more stringent developmental requirements, and their normal development may require the presence of postsynaptic neurons in their close vicinity.
Generic quality of life assessment in psychiatry. Potentials and limitations
Authors: Bullinger M 
Published: July 2002

SummaryThe term ‘quality of life’ has only recently been introduced to psychiatric outcome assessment. Current approaches to such assessment include the development of disease-specific quality of life instruments for psychiatric patient populations as well as the examination of generic quality of life instruments for use in psychiatric outcome studies. The current paper describes the psychiatric work with one example for a generic instrument: the short-form health survey questionnaire (SF-36). The 36 item patient-based questionnaire was developed within the Medical Outcome Study in the United States, was translated, validated and standardized in several countries and has been used in psychiatric settings. Results of epidemiological studies suggest that the SF-36 is applicable to psychiatric patients, is a psychometrically sound instrument also in this indication and yields relevant information in showing the degree of impairment in quality of life domains as experienced by psychiatric patients. The use of generic instruments in psychiatric population, such as the SF-36, might contribute to a better understanding of patients' quality of life as assessed in epidemiological studies, clinical trials and quality of care evaluations.
Readmitted nonpsychotic patients and their eventual diagnoses. A retrospective study on 64 first-timers of inpatient care in the Psychiatric Clinic of Turku, Finland
Authors: Korkeila JA , Karlsson H , Kujari H 
Published: July 2002

SummaryThis longitudinal study was performed to characterise frequently readmitted patients in a sample of 64 first-timers of inpatient care. Half of the 12 revolving door patients were psychotic at last discharge. The relative risk for diagnostic change in the Axis I group was nine times higher than in the personality disorder group.
Abivertinib synergistically strengthens the anti‐leukemia activity of venetoclax in acute myeloid leukemia in a BTK‐dependent manner
Authors: Huang Shujuan , Li Chenying , Zhang Xiang , Pan Jiajia , Li Fenglin , Lv Yunfei , Huang Jingwen , Ling Qing , Ye Wenle , Mao Shihui , Huang Xin , Jin Jie 
Published: June 2020

B‐cell lymphoma 2 (BCL‐2), a crucial member of the anti‐apoptotic BCL‐2 family, is frequently dysregulated in cancer and plays an important role in acute myeloid leukemia (AML). Venetoclax is a highly selective BCL‐2 inhibitor that has been approved by the FDA for treating elderly AML patients. However, the emergence of resistance after long‐term treatment emphasizes the need for a deeper understanding of the potential mechanisms of resistance and effective rescue methods. By using RNA‐seq analysis in two human AML cohorts made up of three patients with complete remission and three patients without remission after venetoclax treatment, we identified that upregulation of BTK enabled AML blast resistance to venetoclax. Interestingly, we found that abivertinib, an oral BTK inhibitor, could synergize with venetoclax to inhibit the proliferation of primary AML cells and cell lines. It is worth noting that the combination of the two effectively enhanced the sensitivity of two AML patients (AML#3 and AML#12) to venetoclax. In this study, we demonstrated that combined use of the two drugs can synergistically inhibit the colony‐forming capacity of AML cells, arrest the AML cell cycle in the G0/G1 phase, and inhibit the BCL‐2 anti‐apoptotic family protein, activating the caspase family to induce apoptosis. Mechanistically, knockdown of BTK in AML cell lines impaired the synergistic effect of the two drugs. In vivo study showed similar results as those seen in vitro. Abivertinib in combination with venetoclax could significantly prolong the survival time and reduce the tumor burden of MV4‐11‐NSG mice compared with those of control and single‐agent groups. Our in vitro and in vivo studies have shown that the combination of abivertinib and venetoclax may benefit AML patients, especially in patients resistant to venetoclax or those that relapse. New clinical trials will be planned.
A review of patient questions from physicist—patient consults
Authors: Atwood Todd F. , Brown Derek W. , Juang Titania , Moore Kevin L. , McConnell Kristen A. , Steers Jennifer M. , Murphy James D. , Mundt Arno J. , Pawlicki Todd 
Published: June 2020

AbstractPurposeTo provide insight into the types of questions asked to medical physicists by patients during one‐on‐one physicist–patient consults at one institution.Materials and MethodsMedical physicists trained in patient communication techniques met with patients to provide an overview of the treatment planning and delivery processes, discuss the patient's treatment plan, and answer any technical questions. From August 2016 to December 2019, 152 physicist–patient consults were conducted. In the initial months of the study (August 2016—December 2017), following each physicist–patient consult, all patient questions were documented by the physicists. For the remaining time period (January 2018—December 2019), any newly encountered questions were periodically added to the list. The questions were compiled into a comprehensive list and organized into categories.ResultsThere were a total of 88 unique patient questions. These questions fit into four topical categories. Fifty‐four questions (61.4%) were in the “Treatment Planning and Delivery Questions” category, 15 questions (17.1%) were in the “General Radiation Questions or Concerns” category, 13 questions (14.8%) were in the “Safety and Quality Assurance Questions” category, and 6 questions (6.8%) were in the “Medical Questions” category. Overall, patients were primarily concerned about how radiation works, the treatment planning and delivery processes, and what is being done to keep them safe throughout their treatment.ConclusionPhysicist–patient consults provided an opportunity to address the technical aspects of radiation therapy with patients in greater detail. The fact that patient questions could be conveniently grouped into only four topical categories indicates that it may be straightforward for other medical physicists to prepare for effectively addressing technical questions during physicist–patient consults.
Impaired cognition is related to microstructural integrity in relapsing remitting multiple sclerosis
Authors: Zhao Lin , Ng Angel , Chen Qianyun , Lam Bonnie , Abrigo Jill , Au Cheryl , Mok Vincent C. T. , Wong Adrian , Lau Alexander Y. 
Published: June 2020

AbstractBackgroundCognitive impairment is common in multiple sclerosis (MS). However, the relationship between cognitive deficits and microstructural abnormalities in Chinese MS patients remains unclear. We aimed to investigate the importance of microstructural abnormalities and the associations with cognitive impairment in Chinese MS patients.MethodsThree‐dimensional T1‐weighted magnetic resonance imaging (MRI) scans were obtained from 36 relapsing remitting MS patients. Diffusion tensor imaging (DTI) scans were acquired for 29 (81%) patients. Cognitive impairment was assessed using a comprehensive neuropsychological battery. Patients were classified into cognitively impaired (CI) group and cognitively preserved (CP) group. Using volBrain and FSL software, we assessed white matter lesion burden, white matter (WM) and gray matter (GM) volumetric as well as microstructural diffusivity. MRI variables explaining cognitive impairment were analyzed.ResultsFifteen (42%) patients were classified as CI. Verbal learning and memory was the most commonly impaired domain (n = 16, 44%). CI patients had lower mean skeleton fractional anisotropy (FA) value than CP patients (275.45 vs. 283.61 × 10−3, P = 0.023). The final predicting model including demographic variables and global skeleton mean diffusivity (MD) explained 43.6% of variance of the presence of cognitive impairment (β = 0.131, P = 0.041). CI patients showed a widespread change of microstructural integrity comparing to CP patients, which was rarely overlapping with lesion probability map. Microstructural abnormalities in corpus callosum were associated with performance in verbal learning and memory, processing speed and selective attention (P < 0.05).ConclusionLoss of microstructural integrity demonstrated by DTI helps explain cognitive dysfunction in Chinese MS patients.
Enhanced Sensitivity of Capacitive Pressure and Strain Sensor Based on CaCu3Ti4O12 Wrapped Hybrid Sponge for Wearable Applications
Authors: Chhetry Ashok , Sharma Sudeep , Yoon Hyosang , Ko Seokgyu , Park Jae Yeong 
Published: June 2020

AbstractPressure sensors with highly sensitive and flexible characteristics have extensive applications in wearable electronics, soft robotics, human–machine interface, and more. Herein, an effective strategy is explored to enhance the sensitivity of the capacitive pressure sensor by fabricating a dielectric hybrid sponge consisting of calcium copper titanate (CaCu3Ti4O12, CCTO), a giant dielectric permittivity material, in polyurethane (PU). An ultrasoft CCTO@PU hybrid sponge is fabricated via dip‐coating the PU sponge into surface‐modified CCTO nanoparticles using 3‐aminopropyl triethoxysilane. The overall results show that the –NH2 functionalized CCTO attributes proper adhesion of CCTO with the –OCN group of the PU to enhance interfacial polarization leading to a high dielectric permittivity (167.05) and low loss tangent (0.71) beneficial for flexible pressure sensing applications. Moreover, the as‐prepared CCTO@PU hybrid sponge at 30 wt% CCTO concentration exhibits excellent electromechanical properties with an ultralow compression modulus of 27.83 kPa and a high sensitivity of 0.73 kPa−1 in a low‐pressure regime (<1.6 kPa). Finally, pressure and strain sensing performance is demonstrated for the detection of human activities by mounting the sensor on various parts of the human body. The work reveals a new opportunity for the facile fabrication of high performance CCTO‐based capacitive sensors with multifunctional properties.
Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model
Authors: Haase Kristina , Offeddu Giovanni S. , Gillrie Mark R. , Kamm Roger D. 
Published: June 2020

AbstractDrug discovery and efficacy in cancer treatments are limited by the inability of pre‐clinical models to predict successful outcomes in humans. Limitations remain partly due to their lack of a physiologic tumor microenvironment (TME), which plays a considerable role in drug delivery and tumor response to therapy. Chemotherapeutics and immunotherapies rely on transport through the vasculature, via the smallest capillaries and stroma to the tumor, where passive and active transport processes are at play. Here, a 3D vascularized tumor on‐chip is used to examine drug delivery in a relevant TME within a large bed of perfusable vasculature. This system demonstrates highly localized pathophysiological effects of two tumor spheroids (Skov3 and A549), which cause significant changes in vessel density and barrier function. Paclitaxel (Taxol) uptake is examined through diffusivity measurements, functional efflux assays, and accumulation of the fluorescent‐conjugated drug within the TME. Due to vascular and stromal contributions, differences in the response of vascularized tumors to Taxol (shrinkage and CD44 expression) are apparent compared with simpler models. This model specifically allows for examination of spatially resolved tumor‐associated endothelial dysfunction, likely improving the representation of in vivo drug distribution, and has potential for development into a more predictable model of drug delivery.