bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inconsistent social rhythms are associated with abdominal adiposity after involuntary job loss: An observational study
Authors: Haynes Patricia L. , Apolinar Gabriella R. , Mayer Candace , Kobayashi Ume , Silva Graciela E. , Glickenstein David A. , Thomson Cynthia A. , Quan Stuart F. 
Published: December 2020

AbstractObjectiveUnemployment is an established risk factor for obesity. However, few studies have examined obesity‐related health behavior after involuntary job loss specifically. Job loss confers a disruption in daily time structure that could lead to negative metabolic and psychological outcomes through chronobiological mechanisms. This study examines whether individuals with unstable social rhythms after involuntary job loss present with higher abdominal adiposity than individuals with more consistent social rhythms and whether this relationship varies as a function of depressive symptoms.MethodsCross‐sectional baseline data (n = 191) from the ongoing Assessing Daily Activity Patterns in occupational Transitions (ADAPT) study were analyzed using linear regression techniques. Participants completed the Social Rhythm Metric‐17 (SRM) daily over 2 weeks. They also completed the Beck Depression Inventory II (BDI‐II) and participated in standardized waist circumference measurements (cm).ResultsA significant interaction emerged between SRM and BDI‐II demonstrating that less consistent social rhythms were associated with larger waist circumference at lower levels of depressive symptoms. Additional exploratory analyses demonstrated a positive association between the number of daily activities performed alone and waist circumference when controlling for symptoms of depression.ConclusionThese findings are the first to demonstrate a relationship between social rhythm stability and abdominal adiposity in adults who have recently, involuntarily lost their jobs. Results highlight the moderating role of depressive symptoms on daily routine in studies of metabolic health. Future prospective analysis is necessary to examine causal pathways.
Characteristics and prognosis of embryonal rhabdomyosarcoma in children and adolescents: An analysis of 464 cases from the SEER database
Authors: Wang Xinyu , Feng Jun , Li Zhe , Zhang Xin , Chen Jun , Feng Guoshuang 
Published: December 2020

ABSTRACTImportanceAs the most common subtype of pediatric rhabdomyosarcoma (RMS), the prognosis of embryonal RMS has rarely been investigated solely.ObjectiveTo perform a population‐based study to characterize the prognosis of embryonal RMS in children and adolescents.MethodsDemographic and clinical features were retrospectively evaluated in selected patients with embryonal RMS registered in the Surveillance, Epidemiology, and End Results (SEER) program from 1988 to 2016. Survival curves were compared using the log‐rank test. A multivariate Cox proportional hazards model was developed to assess the impact of each factor on the overall survival. A nomogram was constructed based on the results of Cox regression model.ResultsA total of 464 patients were included in the analysis, among which 64.6% were male and 70.2% were white patients. About 38.6% and 26.3% of the patients were at 1–4 years and 5–9 years, respectively. Cox analysis showed that patients at age group 5–9 years had the lowest risk of mortality (hazard ratio [HR], 0.277; 95% confidential interval [CI], 0.123–0.620), compared with patients diagnosed at less than 1‐year‐old, and age group 1–4 years had the second‐best prognosis. Patients having distant tumors had significantly higher mortality risk (HR, 4.842; 95% CI, 2.804–8.362) than the patients with localized tumor. Compared with receiving no surgery or radiotherapy, receiving any combination of surgery and radiotherapy would lower the risk of mortality significantly (for surgery without radiotherapy: HR, 0.418; for radiotherapy without surgery: HR, 0.405; and for surgery plus radiotherapy: HR, 0.410).InterpretationAge, stage at diagnosis, and treatment received were found to be the most important predictors of the overall survival of pediatric embryonal RMS.
Severe acute respiratory syndrome coronavirus 2‐induced multisystem inflammatory syndrome in children
Authors: Feng Zhiguan , Bao Yanmin , Yang Yonghong , Zheng Yuejie , Shen Kunling 
Published: December 2020

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐induced multisystem inflammatory syndrome in children (MIS‐C) is a life‐threatening illness that has been reported in the United States and Europe. It affects multiple organ systems and often requires patient admission to an intensive care unit. Although some features of MIS‐C overlap with Kawasaki disease, MIS‐C is more common among older children and adolescents, more often affects cardiovascular and gastrointestinal systems, and more frequently presents with elevated inflammatory markers. Rapid and complete clinical recovery is possible in nearly all patients following immunomodulation therapy. Thus far, MIS‐C pathophysiology and long‐term prognosis are not sufficiently clear; further studies are needed.
TALEN‐mediated generation of Nkx3.1 knockout rat model
Authors: Lee Ji Min , Kim Ukjin , Yang Hyokyung , Ryu Bokyeong , Kim Jin , Sakuma Tetsushi , Yamamoto Takashi , Park Jae‐Hak 
Published: December 2020

AbstractBackgroundRecent developments in gene editing, using transcriptional activator‐like effector nucleases (TALENs), have greatly helped the generation of genetically engineered animal models. The NK3 homeobox 1 (NKX3.1) protein plays important roles in prostate development and protein production, and functions as a tumor suppressor. Recently, NKX3.1 was shown to be associated with breast cancer in humans.MethodsOur aim was to create a new rat model to elucidate the functions of NKX3.1. To that end, we generated Nkx3.1 knockout rats using TALENs and analyzed their phenotype. TALEN‐mediated Nkx3.1 knockout was confirmed by T7 endonuclease I (T7E1) assay and DNA sequencing. Prostate weight and fertility were evaluated in the knockout rats, besides determining the proportion of epithelial cells and messenger RNA (mRNA) expression of genes associated with carcinogenesis. Breast tumors were examined by histopathology.ResultsResults suggested Nkx3.1 knockout rats have reduced fertility, decreased prostate weights, and increased epithelial cell layers. The mRNA expression of genes related to prostate carcinogenesis, namely Ar, Akt, and Pi3k, also increased. Moreover, the Nkx3.1 knockout rats often developed malignant breast tumors.ConclusionsWe, therefore, successfully created the first Nkx3.1 knockout rat model, using TALEN‐mediated gene targeting, and used it to identify defects associated with Nkx3.1 deficiency, not previously observed in mice. Loss of Nkx3.1 in rats led to lower reproductive capacity, and decreased prostate weights, apart from the risk of developing breast cancer. We, thus, proposed Nkx3.1 knockout rats as reliable models for studying the role of NKX3.1 in decreased prostate weights, fertility, and breast cancer, as well as in prostate cancer.
An electromagnetic tracking implantation navigation system in dentistry with virtual calibration
Authors: Gao Yao , Qin Chunxia , Tao Baoxin , Hu Junlei , Wu Yiqun , Chen Xiaojun 
Published: December 2020

AbstractBackgroundDental implant placement navigation systems based on optical tracking have been widely used in clinics. However, electromagnetic (EM) navigation method that does not suffer from problems of hidden line‐of‐light has not yet been described.MethodsThis work proposes an EM‐guided navigation method named TianShu‐ESNS with virtual calibration. Model (12 implants) and animal experiments (pig head: six implants) were conducted to evaluate its performance and stability.ResultThe mean virtual calibration error was 0.83 ± 0.20 mm. The mean deviations at the entry point, end point and angle in the phantom experiment of TianShu‐ESNS were 1.23 ± 0.17 mm, 1.59 ± 0.20 mm and 1.83 ± 0.27°, respectively. In the animal experiment, the same deviations were 1.25 ± 0.07 mm, 1.57 ± 0.35 mm and 1.90 ± 0.60°, respectively.ConclusionsThe experimental results show that TianShu‐ESNS with the virtual calibration method could serve as a promising tool to eliminate the line‐of‐light hidden problem and simplify operation procedure in dental implant placement.
Is all conflict the same? The role of perceived intensity in understanding its effects
Authors: Burnard Mark , Bruk‐Lee Valentina , Snihur Alexander , Allen Josh 
Published: December 2020

AbstractWhile interpersonal conflict at work continues to draw attention, researchers have rarely considered the role that conflict intensity plays in amplifying individuals' affective reactions to it. Hence, this study examines conflict intensity as a moderator of the relationship between interpersonal conflict and perceived stress, physical symptoms, and job satisfaction, through negative affect. A total of 306 employees from various industries participated in this cross‐sectional study. Supporting and expanding an emotion‐centered model of conflict, results indicated that the indirect effects of conflict on the study's outcomes were higher when participants perceived the conflict to be of medium and high‐level intensity.
Sensitivity‐Enhancing Strategies in Optical Biosensing
Authors: Kim Youngsun , Gonzales John , Zheng Yuebing 
Published: December 2020

AbstractHigh‐sensitivity detection of minute quantities or concentration variations of analytes of clinical importance is critical for biosensing to ensure accurate disease diagnostics and reliable health monitoring. A variety of sensitivity‐improving concepts have been proposed from chemical, physical, and biological perspectives. In this review, elements that are responsible for sensitivity enhancement are classified and discussed in accordance with their operating steps in a typical biosensing workflow that runs through sampling, analyte recognition, and signal transduction. With a focus on optical biosensing, exemplary sensitivity‐improving strategies are introduced, which can be developed into “plug‐and‐play” modules for many current and future sensors, and discuss their mechanisms to enhance biosensing performance. Three major strategies are covered: i) amplification of signal transduction by polymerization and nanocatalysts, ii) diffusion‐limit‐breaking systems for enhancing sensor–analyte contact and subsequent analyte recognition by fluid‐mixing and analyte‐concentrating, and iii) combined approaches that utilize renal concentration at the sampling and recognition steps and chemical signal amplification at the signal transduction step.
Label‐Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics
Authors: Tavassoli Hossein , Rorimpandey Prunella , Kang Young Chan , Carnell Michael , Brownlee Chris , Pimanda John E , Chan Peggy P.Y. , Chandrakanthan Vashe 
Published: December 2020

AbstractTo advance the understanding of cardiomyocyte (CM) identity and function, appropriate tools to isolate pure primary CMs are needed. A label‐free method to purify viable CMs from mouse neonatal hearts is developed using a simple particle size‐based inertial microfluidics biochip achieving purities of over 90%. Purified CMs are viable and retained their identity and function as depicted by the expression of cardiac‐specific markers and contractility. The physico‐mechanical properties of sorted cells are evaluated using downstream real‐time deformability cytometry. CMs exhibited different physico‐mechanical properties when compared with non‐CMs. Taken together, this CM isolation and phenotyping method could serve as a valuable tool to progress the understanding of CM identity and function, and ultimately benefit cell therapy and diagnostic applications.
Enhancement of Mass Transport for Oxygen Reduction Reaction Using Petal‐Like Porous Fe‐NC Nanosheet
Authors: Shao Chunfeng , Zhuang Shiguang , Zhang Haocheng , Jiang Qike , Xu Xiaoyan , Ye Jianshan , Li Baitao , Wang Xiujun 
Published: December 2020

AbstractNitrogen‐coordinated single‐atom catalysts (SACs) have emerged as a new frontier for accelerating oxygen reduction reaction (ORR) owing to the optimal atom efficiency and fascinating properties. However, augmenting the full exposure of active sites is a crucial challenge in terms of simultaneously pursuing high metal loading of SACs. Here, petal‐like porous carbon nanosheets with densely accessible Fe‐N4 moieties (FeNC‐D) are constructed by combining the space‐confinement of silica and the coordination of diethylenetriaminepentaacetic acid. The resulted FeNC‐D catalyst possesses an enhanced mesoporosity and a balanced hydrophobicity/hydrophilicity, which can facilitate mass transport and advance the exposure of inaccessible Fe‐N4 sites, resulting in efficient utilization of active sites. By virtue of the petal‐like porous architecture with maximized active site density, FeNC‐D demonstrates superior ORR performance in a broad pH range. Remarkably, when utilized as the air cathode in Zn‐air battery (ZAB) and microbial fuel cell (MFC), the FeNC‐D‐based device displays a large power density (356 mW cm−2 for ZAB and 1041.3 mW m−2 for MFC) and possesses remarkable stability, substantially outperforming the commercial Pt/C catalyst.
Preclinical studies of transcranial photobiomodulation in the neurological diseases
Authors: You Jing , Bragin Anatol , Liu Hanli , Li Lin 
Published: December 2020

AbstractPhotobiomodulation (PBM) takes advantage of red and near‐infrared light to induce therapeutic effects on various kinds of diseases, with transcranial PBM (tPBM) attracting most attention on neurological diseases. Displaying a noninvasive superiority over traditional treatment, tPBM is increasingly studied among research groups. Growing numbers of studies have been conducted in the last decade regarding neurological diseases; however, the research objects and lighting parameters among these papers varied from each other. This article introduces the biophotonics nature of PBM, records the experimental parameters of preclinical studies since 2014 and summarizes the application of tPBM on the neurobiological diseases in the past two decades. Under the summarized guidance of parameter setup, tPBM will be shining light in the prevention and treatment of neurological diseases.image
Surface water quality management for drinking use in El‐Beheira Governorate, Egypt
Authors: Hussien Amira Kh. , Rashwan Ibrahim M.H. , Elshemy Mohamed 
Published: December 2020

AbstractThis research was initiated to assess and manage water quality status of fourteen surface drinking water intakes in El‐Beheira Governorate, Egypt. The study was conducted on four main branches of water resources in the governorate. Three water quality indices (WQIs) and two multivariate statistical techniques were applied, based on the Egyptian guidelines for the Nile River. Water quality records were collected for two successive years, 2014 and 2015, and were analyzed by descriptive statistics. The results revealed the critical water quality status of the four branches at the fourteen intakes. The multivariate statistical techniques returned the critical water quality conditions to the agricultural drainage and the domestic wastewater discharges. In addition, a new software application was developed to manage WQIs calculation. An urgent water quality monitoring and assessment system should be initiated for the drinking water resources all over Egypt, based on the developed water quality assessment techniques of this study.Practitioner points

Three different WQIs and two different statistics tools were applied.
Critical water quality status for the investigated surface drinking water intakes was reported.
Agricultural drainage then domestic effluents are the main pollution sources.
A new software application was developed to calculate WQIs to support decision makers.
Central exclusive production of W boson pairs in pp collisions at the LHC in hadronic and semi-leptonic final states
Authors: Baldenegro C. , Biagi G. , Legras G. , Royon C. 
Published: December 2020

Abstract
We present a phenomenology study on central exclusive production of W+W− boson pairs in proton-proton collisions at the Large Hadron Collider at 14 TeV using the forward proton detectors, such as the ATLAS Forward Proton or the CMS-TOTEM Precision Proton Spectrometer detectors. Final states where at least one of the W bosons decay hadronically in a large-radius jet are considered. The latter extends previous efforts that consider solely leptonic final states. A measurement of exclusive W+W− also allows us to further constrain anomalous quartic gauge boson interactions between photons and W bosons. Expected limits on anomalous quartic gauge couplings $$ {a}_{0,C}^W $$

a

0
,
C

W

associated to dimension-six effective operators are derived for the hadronic, semi-leptonic, and leptonic final states. It is found that the couplings can be probed down to one-dimensional values of $$ {a}_0^W=3.7\times {10}^{-7}{\mathrm{GeV}}^{-2} $$

a
0
W

=
3.7
×

10

−
7

GeV

−
2

and $$ {a}_C^W=9.2\times {10}^{-7}{\mathrm{GeV}}^{-7} $$

a
C
W

=
9.2
×

10

−
7

GeV

−
7

at 95% CL at an integrated luminosity of 300 fb−1 by combining all final states, compared to values of about $$ {a}_0^W=4\times {10}^{-6}{\mathrm{GeV}}^{-2} $$

a
0
W

=
4
×

10

−
6

GeV

−
2

and $$ {a}_C^W=1\times {10}^{-5}{\mathrm{GeV}}^{-2} $$

a
C
W

=
1
×

10

−
5

GeV

−
2

at 95% CL expected for the leptonic channel alone.
Topological operators and completeness of spectrum in discrete gauge theories
Authors: Rudelius Tom , Shao Shu-Heng 
Published: December 2020

Abstract
In many gauge theories, the existence of particles in every representation of the gauge group (also known as completeness of the spectrum) is equivalent to the absence of one-form global symmetries. However, this relation does not hold, for example, in the gauge theory of non-abelian finite groups. We refine this statement by considering topological operators that are not necessarily associated with any global symmetry. For discrete gauge theory in three spacetime dimensions, we show that completeness of the spectrum is equivalent to the absence of certain Gukov-Witten topological operators. We further extend our analysis to four and higher spacetime dimensions. Since topological operators are natural generalizations of global symmetries, we discuss evidence for their absence in a consistent theory of quantum gravity.
A note on the $$ \mathcal{N} $$ = 2 super-$$ {\mathcal{W}}_3 $$ holographic dictionary
Authors: Castro Alejandra , Faraggi Alberto , Osorio Israel 
Published: December 2020

Abstract
This is a long-overdue companion paper to [1]. We study the relation between sl(3|2) Chern-Simons supergravity on AdS3 and two-dimensional CFT’s with $$ \mathcal{N} $$
N
= 2 super-$$ {\mathcal{W}}_3 $$

W
3

symmetry. Specifically, we carry out a complete analysis of asymptotic symmetries in a basis that makes the superconformal structure transparent, allowing us to establish the precise dictionary between currents and transformation parameters in the bulk and their boundary counterparts. We also discuss the incorporation of sources and display in full detail the corresponding holographic Ward identities. By imposing suitable hermiticity conditions on the CFT currents, we identify the superalgebra su(2, 1|1, 1) as the appropriate real form of sl(3|2) in Lorentzian signature. We take the opportunity to review some of the properties of the $$ \mathcal{N} $$
N
= 2 super-$$ {\mathcal{W}}_3 $$

W
3

conformal algebra, including its multiplet structure, OPE’s and spectral flow invariance, correcting some minor typos present in the literature.
Correlation functions in massive Landau-Ginzburg orbifolds and tests of dualities
Authors: Gu Wei 
Published: December 2020

Abstract
In this paper we discuss correlation function computations in massive topological Landau-Ginzburg orbifolds, extending old results of Vafa [1]. We then apply these computations to provide further tests of the nonabelian mirrors proposal and two-dimensional Hori-Seiberg dualities with (S)O± gauge groups and their mirrors.
Bootstrapping boundary-localized interactions
Authors: Behan Connor , Di Pietro Lorenzo , Lauria Edoardo , van Rees Balt C. 
Published: December 2020

Abstract
We study conformal boundary conditions for the theory of a single real scalar to investigate whether the known Dirichlet and Neumann conditions are the only possibilities. For this free bulk theory there are strong restrictions on the possible boundary dynamics. In particular, we find that the bulk-to-boundary operator expansion of the bulk field involves at most a ‘shadow pair’ of boundary fields, irrespective of the conformal boundary condition. We numerically analyze the four-point crossing equations for this shadow pair in the case of a three-dimensional boundary (so a four-dimensional scalar field) and find that large ranges of parameter space are excluded. However a ‘kink’ in the numerical bounds obeys all our consistency checks and might be an indication of a new conformal boundary condition.
A continuously perturbed Dirichlet energy with area-preserving stationary points that ‘buckle’ and occur in equal-energy pairs
Authors: Bevan Jonathan J. , Deane Jonathan H. B. 
Published: December 2020

AbstractWe exhibit a family of convex functionals with infinitely many equal-energy$$C^1$$C1stationary points that (i) occur in pairs$$v_{\pm }$$v±satisfying$$\det \nabla v_{\pm }=1$$det∇v±=1on the unit ballBin$${\mathbb {R}}^2$$R2and (ii) obey the boundary condition$$v_{\pm }=\text {id}$$v±=idon$$ \partial B$$∂B. When the parameter$$\epsilon $$ϵupon which the family of functionals depends exceeds$$\sqrt{2}$$2, the stationary points appear to ‘buckle’ near the centre ofBand their energies increase monotonically with the amount of buckling to whichBis subjected. We also find Lagrange multipliers associated with the maps$$v_{\pm }(x)$$v±(x)and prove that they are proportional to$$(\epsilon -1/\epsilon )\ln |x|$$(ϵ-1/ϵ)ln|x|as$$x \rightarrow 0$$x→0inB. The lowest-energy pairs$$v_{\pm }$$v±are energy minimizers within the class of twist maps (see Taheri in Topol Methods Nonlinear Anal 33(1):179–204, 2009 or Sivaloganathan and Spector in Arch Ration Mech Anal 196:363–394, 2010), which, for each$$0\le r\le 1$$0≤r≤1, take the circle$$\{x\in B: \ |x|=r\}$${x∈B:|x|=r}to itself;a fortiori, all$$v_{\pm }$$v±are stationary in the class of$$W^{1,2}(B;{\mathbb {R}}^2)$$W1,2(B;R2)mapswobeying$$w=\text {id}$$w=idon$$\partial B$$∂Band$$\det \nabla w=1$$det∇w=1inB.