bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoptotic Effects of Prunus persica (L) Batsch Leaves against Breast Cancer Cell Line (MDA-MB-231) and Cervical Cancer Cell Line (HeLa) In Vitro
Authors: Bhat Firdous Ahmad , Shafi Sabeeha , Hilal Nazia , Bhat Showkat Ahmad , Rafiqee Aneequa 
Published: July 2020

Background: Apoptosis is a normal physiological phenomenon that plays a pivotal role during embryonic development, retention of tissue homeostasis and pathology. The experimental investigation of apoptotic processes is still challenging and routinely based on the assessment of molecular events like chromatin fragmentation and caspase enzyme activity. The present study was conducted to evaluate the apoptosis inducing effect of the Methanol, aqueous and chloroform extracts of Prunus persica leaves.
Methods: Different extracts were obtained by cold extraction process using Methanol, water and Chloroform as solvents. Crude extracts were screened for different phytochemical constituents like flavonoids, tannins, sugars, saponins, and glycosides etc. The apoptotic effect of Prunus persica leaves was examined by DAPI staining assay against MDA-MB-231 (Human breast cancer cell line) and HeLa (Human cervical cancer cell line).
Results: The results of the studies revealed that the Chloroform extract have tremendous apoptotic activity on MDA-MB-231 cells and methanolic extract have good apoptotic activity on HeLa cells. Nuclear morphological changes assessed by DAPI shows changes in morphology, apoptotic body formation, cell shrinkage, nuclei that were broken into discrete fragments and cell budding that resulted in cells of various sizes.
Conclusion: The phytochemical screening reveals the presence of alkaloids, tannins, Saponins, steroids and flavonoids. The Chloroform extract has shown more effectiveness and less toxicity against MDA-MB-231 and Methanol extract was more apoptotic against HeLa in comparison to others. The present findings clearly indicated that Prunus persica leaves showed dose dependant cytotoxicity.
Free Radical Scavenging Activity, Reducing Power and Anti-Hemolytic Capacity of Algerian Drimia maritima Baker Flower Extracts
Authors: Rezzagui Abir , Senator Abderrahmane , Benbrinis Soumia , Bouriche Hamama 
Published: July 2020

This study was undertaken to evaluate the antioxidant and anti-hemolytic properties of Algerian Drimia maritima Baker flower extracts. Determination of phenolic content was carried out to estimate the chemical composition of D. maritima extracts. Antioxidant properties were investigated in all extracts using free radical scavenging activity (against DPPH, ABTS, hydroxyl radical, and superoxide anion), reducing power, inhibition of lipid peroxidation, and anti-hemolytic capacity. Phenolic determination revealed that D. maritima flowers contain phenolic compounds, flavonoids, and tannins. Ethyl acetate extract showed the highest reducing power and scavenging activity using DPPH and ABTS assays. However, aqueous extract was the most effective against hydroxyl radical, superoxide anion, and lipid peroxidation. The half-time of hemolysis indicates that chloroform extract exhibited the best anti-hemolytic capacity in the AAPH induced hemolysis model. The results of this study suggest that D. maritima could be used as a possible source of antioxidant phenolic compounds and that further determination of these compounds may provide more information on their medicinal value.
Keywords: Drimia maritima, phenolic compounds, scavenging activity, reducing power, anti-hemolytic.
Ethnobotanical Study, Anatomical Study and Phytochemical Screening of Aristolochia longa L.
Authors: Merouani N. , Boukhebti H. , Belhattab R. 
Published: July 2020

Aristolochia longa L. (Aristolochiaceae) is used in Algerian traditional medicine. The ethnobotanical study conducted in the region of Setif (East Algeria) has as an objective of evaluating the potential of the region of Aristolochia longa L. used in the treatment of different diseases. A questionnaire was used which consisted of the diseases treated by this plant, the part of the plant used in the treatment and how to use this plant. The survey targeted 100 people from the local population. We also evaluated the phytochemical composition of the aerial parts (stems and leaves), fruits and tubers. Our results showed that A. longa is widely used to treat several ailments such as cancer (43%), diabetes (17%), and treatment of wounds in cattle (12%), and intestinal and stomach diseases (9 and 7%), the most used part is tubers by 70%.Crushed tubers are commonly mixed with honey(44%), milk(24%), water (8%). Results of the phytochemical screening revealed that A. longa contained various bioactive compounds, including polyphenols, flavonoids, saponins, terpenoids, and Alkaloids. In addition, there is very little information concerning the anatomical and morphological structure of this species of Setif region (Algeria), a preliminary study on anatomy of this plant is therefore reported in this paper. These preliminary results could be used to justify the traditional use of this plant and their bioactive substances could be exploited for therapeutic purposes such as antioxidant, antimicrobial and anti-inflammatory, and may be considered as a promising source of new drugs for treating cancer.
Keywords: Aristolochia longa L., ethnobotany Setif(Algeria), anatomical study of plant, phytochemical screening.
Is there an association between Anti-Citrullinated Peptide Antibodies and the Severity of Rheumatoid Arthritis Parameters in Algerian Patients?
Authors: OUALI Siheme , ZEMRI Khalida , SELLAM Ferial , HARIR Noria , BENIASSA Zahira , HEBRI Sid Tadj , BENSABER Ouassini , ELMEHADJI Douniazad , NADJI Zouaoui , KAROUBI Karima 
Published: July 2020

Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA).
Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0.
Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050. Patients with Anti-CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence.
Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity.
Formulation and Physical Characterization of Bio-Degradable Chitosan-Poloxamer Gel Base for Local Drug Delivery
Authors: Dahake Prasanna T. , Baliga Sudhindra M , Punse Triveni , Biyani Dinesh M , Raut Neha , Umekar Milind J 
Published: July 2020

Objective: Thermo-modulated in-situ hydrogel (TSHG) are formulated routinely utilizing poloxamer for extended drug release. However physical properties of such formulations may have some flaws, which can be rectified using a combination of polymers with better physical properties such as chitosan. The purpose of the present study was to fabricate biodegradable chitosan-poloxamer-based in-situ drug delivery systems and assessment of their physical properties.
Methods: The present chitosan-poloxamer gel base was formulated using a two-stage method. Initially, chitosan gel was prepared by dissolving 1% w/w chitosan in glacial acetic acid. The poloxamer gel was prepared using “cold method”. The final chitosan-poloxamer gel base was prepared by mixing equal amounts of both solutions and evaluated for physical and mechanical properties.
Result and Discussion: The DSC thermogram demonstrated no obvious interactions among ingredients or micellization temperature. The gelation temperature of the gel was between 27 and 330C. The pH was 7 with slight clarity. The viscosity of the gel ranged from 15.14 to 41.19 pa.s. The gel was syringable between 4-300C and biodegradable under physiological conditions. The mean particle size of the gel under SEM was found in the range of 300-554 nm.
Conclusion: After the evaluation of the formulation, it can be concluded that all the ingredients in the gel showed good compatibility with each other, which could form a stable and homogeneous gel with favorable mechanical and physical properties.
Keywords: chitosan, drug delivery system, hydrogels, poloxamer
PRAKTEK RE-UPLOAD VIDEO OLEH YOUTUBER DAN KEABSAHAN PEMBAYARANNYA
Authors: Rahman Fazlul 
Published: July 2020

Youtube is a video sharing website created by three former Paypal employees in February 2005, this site allows users to upload, watch and share videos. The company is based in San Bruno, California, and uses Adobe Flash Video and HTML5 technology to display a variety of user-made video content, including movie clips, TV clips and music videos. In addition there are also amateur content such as video blogs, short original videos and educational videos. Currently YouTube has provided two types of licenses on its site, namely Copyright frequency (cannot be re-uploaded by other parties) and Creative Commons BY Protection (CC BY) (may be re-uploaded by other parties). Even so it is not a problem without problems, the problems that still occur on Youtube are cases of copyright on the site, such as the practice of re-uploading videos here for example. This study examines how the validity of income obtained from the video re-upload activity on Youtube in terms of the Ibtikar Rights Perspective in Islam and Muamalah Fiqh. This thesis research includes the type of library research, which is data collection using study studies of books, journals, printed documents, and from sites on the internet. The results of the research conducted by the author in this thesis are unlawful in the practice of re-uploading videos that are carried out solely to obtain personal gain without giving royalties to the relevant producer / label, in other words the act is the same as a trader selling people's property otherwise without the permission of the owner or selling stolen goods, this is clearly detrimental to the creator or copyright holder because the video circulating on youtube is not given permission by the video creator to spread the creation to the public using the Youtube website. In Islam, copyright is known as Haq Ibtikar, namely a special right attached to the original video owner and part of intellectual property, both material and immaterial, so that it must be protected by law. Islam highly respects copyright as a private property right so that the right to ibtikar is classified into the Maqashid Sharia to maintain the existence of ownership of the assets of every Muslim. Every treasure that results from a video re-upload in Islam and Muamalah Fiqh is unlawful, because it is included in violating the rights of others in a vanity. Keywords: Hak Ibtikar, video re-upload, Youtube, copyright infringement
Estimasi Kecepatan Gelombang Geser Bawah Permukaan Pada Lapisan Dangkal Menggunakan Data Mikrotremor di Daerah Mamboro
Authors: Indra Indra , Efendi Rustan , Abdullah Abdullah 
Published: July 2020

Penelitian Estimasi Kecepatan Gelombang Geser Bawah Permukaan Pada Lapisan Dangkal telah dilakukan menggunakan data mikrotremor di Daerah Mamboro Kecamatan Palu Utara Kota Palu. Tujuan penelitian untuk menganalisis kecepatan penjalaran gelombang geser lapisan batuan hingga kedalaman 30 m dan mengetahui tipe dan profil jenis lapisan batuan Daerah Mamboro. Pengambilan data dilakukan pada lintasan yang berbeda yaitu lintasan-1 yang berada disekitar terminal Mamboro, lintasan-2 berada disekitar tempat penampungan ikan dan lintasan-3 berada di lapangan Sekolah Tinggi Ilmu Kesehatan Mamboro. Metode pengambilan data menggunakan Microtremor Array Measurements (MAM) dan metode pengolahan data menggunakan Multi Analysis of Surface Wave (MASW) dengan menggunakan software Surface Wave Analysis Wizard dan software WaveEq dari Geometris. Hasil penelitian menunjukkan bahwa ketiga lintasan tersebut tergolong dalam tipe batuan yang sama yaitu tipe D yang berjenis tanah sedang dengan nilai Vs30 berturut-turut sebesar 243,1 m/s, 243,7 m/s dan 231,1 m/s. Hasil dari hubungan kecepatan gelombang geser terhadap lintasan bawah permukaan pada daerah penelitian tersusun atas pasir tidak tersaturasi, alluvium dan lempung, sehingga daerah penelitian rentan terhadap kerusakan akibat gempa.
Kata Kunci: Gelombang geser, mikrotremor, jenis batuan.
Prediksi Nilai Debit Puncak Menggunakan Metode Muskingum di Sungai Pasangkayu Kecamatan Pasangkayu
Authors: Assiddiq Muh. , Abdullah Abdullah , Rahman Abd. 
Published: July 2020

Penelitian tentang prediksi nilai debit puncak aliran telah dilakukan di Sungai Pasangkayu Kecamatan Pasangkayu Kabupaten Pasangkayu. Penelitian ini dilakukan untuk memprediksi nilai debit puncak yang terjadi di aliran sungai Pasangkayu. Data debit aliran sungai yang diperoleh dari hasil pengukuran diolah dengan menggunakan Metode Muskingum yaitu suatu cara perhitungan yang digunakan dalam penelusuran banjir dengan pendekatan hukum kontinuitas, data kecepatan aliran, kedalaman, jarak tiap pias diolah dengan menggunakan program Microsoft Excel. Dari hasil penelitian diperoleh bahwa debit maksimum aliran masuk sungai Pasangkayu terjadi pada tanggal 17 Maret 2018 pukul 12:00:00 WITA dengan besar debit 18,17 m3 /dt sedangkan debit maksimum aliran keluar terjadi pada hari yang sama pada pukul 10:00:00 WITA dengan besar debit 19,09 m3 /dt. Hal ini disebabkan terjadinya hujan di bagian hulu sungai tepatnya di desa Lalundu yang memiliki aliran ke sungai Pasangkayu. Berdasarkan grafik Muskingum tanggal 18 Maret 2018 menunjukkan bahwa debit puncak bagian hulu (aliran masuk) lebih besar dari pada debit puncak bagian hilir (aliran keluar), perbedaan waktu terjadinya debit puncak antara bagian hulu dan hilir memiliki selisih waktu 1 jam, sedangkan pada tanggal 17 Maret dan 19 Maret 2018 nampak debit puncak aliran masuk lebih kecil dari pada aliran keluar. Hasil penelitian ini menunjukkan bahwa aliran masuk yang lebih besar dari pada aliran keluar yang menyebabkan terjadinya limpasan di permukaan sungai Pasangkayu sehingga terjadi banjir.
Kata kunci: Aliran sungai, debit puncak, metode Muskingum, Microsoft Excel
Model Numerik Sebaran Sedimen Tersuspensi di Muara Sungai Pulege Kabupaten Donggala
Authors: Maryam  , Mudin Yutdam , Abd. Rahman  
Published: July 2020

Sungai Pulege memiliki peran penting sebagai penyalur material tersuspensi dari daerah hulu menuju laut. Proses sebaran sedimen di perairan laut dipengaruhi oleh faktor fisika oseonografi. Tujuan dari penelitian ini adalah memodelkan pola sedimen tersuspensi untuk menentukan sebaran konsentrasinya di muara Sungai Pulege. Dalam penelitian meliputi data primer berupa kosentrasi sedimen tersuspensi, dan debit sungai sedangkan data sekunder berupa peta batimetri, RBI, data pasut, arus dan angin. Penelitian menggunakan metode kuantitatif, analisis sampel sedimen tersuspensi menggunakan metode Gravimetri di laboratorium FMIPA UNTAD dan pembuatan model sebaran konsentrasi sedimen tersuspensi menggunakan pendekatan matematik SED2D dalam Software Surface Water Modelling System (SMS). Hasil penelitian dengan menggunakan modul SED2D menunjukkan bahwa nilai konsentrasi maksimum sedimen tersuspensi yang berada di sekitaran sungai khusususnya di stasiun I sebesar 0.40 gram/liter, dan menyebar kearah sekitaran Perairan Pantai Tanamea khususnya pada stasiun II sebesar 0.03 gram/liter. Nilai debit Sungai Pulege pada saat pengukuran sebesar 14.37 /det. Arus dominan disekitaran Perairan Pantai Tanamea adalah arus pasut, dan kecepatan arus maksimum 0.27 /det. Dari hasil penelitian dapat disimpulkan bahwa nilai konsentrasi sedimen tersuspensi terbesar berada didaerah sungai dan mengecil ketika menuju laut. Hal ini mengakibatkan di daerah muara sungai tidak terjadi pendangkalan dan tidak dapat mengganggu ekosistem, biota laut sekitaran Pantai Tanamea. Hasil penelitian yang diperoleh dapat disimpulkan bahwa sebaran sedimen tarsuspensi di wilayah yang dikaji sangat dipengaruhi oleh arus pasang surut, dan pada Stasiun II arah sebaran sedimen tersuspensi dominan ke barat laut.
Kata kunci : Sedimen tersuspensi, Debit Sungai, SED2D, Perairan Selat Makassar
Analisis Hubungan Lingkar Abdomen dengan Tekanan Darah Berdasarkan Indeks Massa Tubuh (IMT) Pada Orang Dewasa di Desa Lantibung Kabupaten Banggai Laut
Authors: Muhtar Nusrifa , Kasman  
Published: July 2020

Telah dilakukan penelitian tentang hubungan lingkar abdomen dengan tekanan darah berdasarkan Indeks Massa Tubuh (IMT) pada orang dewasa di Desa Lantibung Kabupaten Banggai. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkar abdomen dan tekanan darah berdasarkan IMT (kurus-normal, overweight, dan obesitas) pada masyarakat Desa Lantibung Kabupaten Banggai Laut. Pengolahan data dilakukan dengan menghitung nilai IMT, mengklasifikasikan kategori risiko Cardiac Vasticular Disease (CVD) dari variabel lingkar abdomen dan kategori tekanan darah (TD) dari variabel tekanan darah, dengan menggunakan uji chi kuadrat dan korelasi spearman. Berdasarkan uji statistik, tidak terdapat hubungan antara lingkar abdomen dan tekanan darah berdasarkan indeks massa tubuh (IMT) kurus-normal dan IMT obesitas yang masing-masing nilai korelasi adalah r=-0,142 dan r= 0,086. Terdapat hubungan antara lingkar abdomen dan tekanan darah berdasarkan indeks massa tubuh (IMT) overweight dengan r= 0,426.

Kata kunci: Lingkar abdomen, IMT, tekanan darah, risiko CVD
Evaluasi Variasi Faktor Eksposi Terhadap Dosis Paparan Radiasi Pada Pesawat Sinar-X Model E7242 di RSUD Madani Palu
Authors: Jamaludin Ira Herdianti , Sesa Elisa , Kasman  , Meylin Deice Labania Hosiana 
Published: July 2020

Telah dilakukan penelitian Evaluasi Variasi Faktor Eksposi Terhadap Dosis Paparan Radiasi Pada Pesawat Sinar-X Model E7242 di RSUD Madani Palu. Penelitian ini dilakukan untuk mengetahui pengaruh variasi faktor eksposi terhadap perubahan dosis paparan radiasi pada pesawat sinar-X di RSUD Madani Palu. Penelitian ini dilakukan dengan mengukur dosis paparan radiasinya menggunakan surveymeter. Pada penelitian ini diperoleh laju perubahan faktor eksposi tegangan, kuat arus, waktu penyinaran dan jarak sumber radiasi ke titik pengukuran masing-masing terhadap dosis paparan radiasi adalah 0,0002mR/kV, 0,00003mR/mA, 0,0009mR/ms dan -0,000003mR/mm. Berdasarkan analisis data diperoleh faktor yang sangat mempengaruhi perubahan dosis paparan radiasi sinar-X adalah faktor waktu penyinaran, sebab dibuktikan dengan laju perubahannya yang relatif lebih tinggi dibandingkan dengan faktor-faktor eksposi lainnya. Penelitian ini juga diperoleh bahwafaktor eksposi jarak sumber radiasi ketitik pengukuran berbanding terbalik dengan dosis paparan radiasinya, sehingga menyebabkan energi yang terserap oleh titik pengukuran tersebut semakin kecil.

Kata kunci: Sinar-X, Faktor Eksposi, Dosis Paparan Radiasi, Surveymeter,
Auditors' Use of Formal Advice from Internal Firm Subject Matter Experts: The Impact of Advice Quality and Advice Awareness on Auditors' Judgments
Authors: Wright Nicole S. , Bhattacharjee Sudip 
Published: July 2020

SUMMARY
When subject matter experts are consulted during an audit, the quality of the expert's advice depends upon their ability to fully understand and incorporate client-specific facts into their advice. PCAOB inspection reports suggest that auditors are neglecting to perform the required work to assess the quality of experts' recommendations. This article summarizes a recent study by Wright and Bhattacharjee (2018) examining how receiving expert advice of different levels of quality and the timing of communication making auditors aware of the eventual use an expert, impact auditors' judgments. Auditors who were aware that an expert was going to be used put forth more effort before receiving the expert's advice, and were less in agreement with management's position, than auditors who were unaware. Upon receiving the advice, aware auditors were more discerning and accurate than unaware auditors, providing that the timing and communication of consulting decisions affect auditors' assessments of expert advice.
Fostering Intrinsic Motivational Orientation: A Cost-Effective Method for Encouraging Audit Staff to Speak Up
Authors: Mocadlo Robert P. , Rich Jay S. , Trimble Madeline , Zhou Yuepin (Daniel) 
Published: July 2020

SUMMARY
This article summarizes and outlines practical implications from the findings of “It Goes Without Saying: The Effects of Intrinsic Motivational Orientation, Leadership Emphasis of Intrinsic Goals, and Audit Issue Ambiguity on Speaking Up” (Kadous, Proell, Rich, and Zhou 2019). Through a series of experiments and surveys, the initial paper tests the effect that leadership focus on intrinsic motivation of auditors can have on their willingness to “speak up” with audit issues. Furthermore, they introduce the effects that ambiguity and source of motivation have on their initial findings. We expand this original work by summarizing the empirical findings and elaborating on the practical implications for auditors, managers, academics, and regulators. Applying these findings in practice could be a cost effective and efficient way to operationalize PCAOB AS 1201 and improve audit quality.
INDEPENDENSI KOMISI PEMBERANTASAN KORUPSI: BENARKAH ADA?
Authors: Wahyuningrum Kartika Sasi , Disemadi Hari Sutra , Jaya Nyoman Serikat Putra 
Published: July 2020

Pentingnya independensi yang dimiliki lembaga Komisi Pemberantasan Korupsi (KPK) yaitu untuk mempercepat kinerja lembaga KPK itu sendiri. Namun, disahkannya Undang-Undang Nomor 19 Tahun 2019 tentang Perubahan Kedua Atas Undang-Undang Nomor 30 Tahun 2002 tentang Komisi Pemberantasan Tindak Pidana Korupsi (revisi UU KPK) mengakibatkan pelemahan terhadap lembaga KPK. Pada penelitian doktrinal ini, metode penelitian yang digunakan adalah metode penelitian hukum normatif yaitu metode penelitian hukum yang mendasarkan pada pendekatan perundang-undangan dan pendekatan konseptual dengan menggunakan analisis deskriftif analitis. Hasil dari penelitian ini menunjukan telah hilangnya independensi KPK dengan diubahnya isi dari Pasal 3 UU KPK. Pelemahan lembaga KPK terlihat dengan dibentuknya dewan pengawas, kemudian pegawai KPK harus berasal dari Aparatur Sipil Negara sehingga mengakibatkan terikatnya dengan komando pusat yang membatasi ruang gerak lembaga KPK.