bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demonstration of X-ray Thomson scattering as diagnostics for miscibility in warm dense matter
Authors: Frydrych S. , Vorberger J. , Hartley N. J. , Schuster A. K. , Ramakrishna K. , Saunders A. M. , van Driel T. , Falcone R. W. , Fletcher L. B. , Galtier E. , Gamboa E. J. , Glenzer S. H. , Granados E. , MacDonald M. J. , MacKinnon A. J. , McBride E. E. , Nam I. , Neumayer P. , Pak A. , Voigt K. , Roth M. , Sun P. , Gericke D. O. , Döppner T. , Kraus D. 
Published: May 2020

AbstractThe gas and ice giants in our solar system can be seen as a natural laboratory for the physics of highly compressed matter at temperatures up to thousands of kelvins. In turn, our understanding of their structure and evolution depends critically on our ability to model such matter. One key aspect is the miscibility of the elements in their interiors. Here, we demonstrate the feasibility of X-ray Thomson scattering to quantify the degree of species separation in a 1:1 carbon–hydrogen mixture at a pressure of ~150 GPa and a temperature of ~5000 K. Our measurements provide absolute values of the structure factor that encodes the microscopic arrangement of the particles. From these data, we find a lower limit of $$2{4}_{-7}^{+6}$$
2

4

−
7

+
6

% of the carbon atoms forming isolated carbon clusters. In principle, this procedure can be employed for investigating the miscibility behaviour of any binary mixture at the high-pressure environment of planetary interiors, in particular, for non-crystalline samples where it is difficult to obtain conclusive results from X-ray diffraction. Moreover, this method will enable unprecedented measurements of mixing/demixing kinetics in dense plasma environments, e.g., induced by chemistry or hydrodynamic instabilities.
Melatonin for Treatment-Seeking Alcohol Use Disorder patients with sleeping problems: A randomized clinical pilot trial
Authors: Gendy Marie N. S. , Lagzdins Dina , Schaman Jessika , Le Foll Bernard 
Published: May 2020

AbstractA high percentage of subjects diagnosed with alcohol use disorder (AUD) suffer from sleeping difficulties. Lack of sleep could lead AUD patients to relapse or, sometimes, to suicide. Most of the currently prescribed medications to treat this complex problem retain a high risk of side effects and/or dependence. Therefore, the aim of the current clinical trial is to investigate the possibility of the use of a safer treatment, such as the natural health product melatonin, to treat alcohol-related sleeping problems. Sixty treatment-seeking AUD subjects were assigned to melatonin (5 mg) or placebo for 4 weeks of treatment. Change in sleeping quality which is the primary outcome of the study was assessed using the Pittsburgh sleep quality index (PSQI) scale. Linear mixed models were used to statistically analyze the difference in scores before and after 4 weeks of treatment. There was a reduction in the global PSQI score in both groups with no significant drug effect between groups. In conclusion, the use of melatonin (5 mg)/day didn’t differ from placebo in decreasing sleeping problems in a sample of AUD subjects after 4 weeks of treatment. However, higher doses are worth exploring in future research.
Novel cultivated endophytic Verrucomicrobia reveal deep-rooting traits of bacteria to associate with plants
Authors: Bünger Wiebke , Jiang Xun , Müller Jana , Hurek Thomas , Reinhold-Hurek Barbara 
Published: May 2020

AbstractDespite the relevance of complex root microbial communities for plant health, growth and productivity, the molecular basis of these plant-microbe interactions is not well understood. Verrucomicrobia are cosmopolitans in the rhizosphere, nevertheless their adaptations and functions are enigmatic since the proportion of cultured members is low. Here we report four cultivated Verrucomicrobia isolated from rice, putatively representing four novel species, and a novel subdivision. The aerobic strains were isolated from roots or rhizomes of Oryza sativa and O. longistaminata. Two of them are the first cultivated endophytes of Verrucomicrobia, as validated by confocal laser scanning microscopy inside rice roots after re-infection under sterile conditions. This extended known verrucomicrobial niche spaces. Two strains were promoting root growth of rice. Discovery of root compartment-specific Verrucomicrobia permitted an across-phylum comparison of the genomic conformance to life in soil, rhizoplane or inside roots. Genome-wide protein domain comparison with niche-specific reference bacteria from distant phyla revealed signature protein domains which differentiated lifestyles in these microhabitats. Our study enabled us to shed light into the dark microbial matter of root Verrucomicrobia, to define genetic drivers for niche adaptation of bacteria to plant roots, and provides cultured strains for revealing causal relationships in plant-microbe interactions by reductionist approaches.
Identification of chromosomes in Triticum aestivum possessing genes that confer tolerance to the synthetic auxin herbicide halauxifen-methyl
Authors: Obenland Olivia A. , Riechers Dean E. 
Published: May 2020

AbstractNatural tolerance in hexaploid bread wheat (Triticum aestivum L.) to synthetic auxin herbicides is primarily due to rapid metabolic detoxification, but genes encoding these herbicide-detoxifying enzymes have yet to be identified. Herbicide safeners are commonly applied in wheat to achieve herbicide tolerance by inducing the expression and activity of herbicide-detoxifying enzymes. While safeners have been utilized for decades, knowledge of mechanisms that induce gene expression is limited. Our objective was to identify wheat chromosomes possessing genes that endow natural or safener-induced tolerance to halauxifen-methyl (HM), a postemergence (POST) wheat-selective synthetic auxin herbicide, using alien substitution (the S genome of Aegilops searsii) and aneuploid lines. Two POST rates of HM were applied to seedlings with 1-2 leaves (Zadoks stages 11-12), and the highest HM rate was also applied with the safener cloquintocet-mexyl (CM). Wheat chromosomes possessing genes associated only with natural HM tolerance were identified because Ae. searsii is HM-sensitive but CM-responsive. Lines with substitutions for 5A and 5B displayed sensitivity to HM, and experiments with nullisomic-tetrasomic (NT) lines further indicated major genes associated with HM tolerance are present on 5A and 5B chromosomes. However, the genes on 5A appear to play a larger role because lines lacking 5A chromosomes displayed more sensitivity than lines lacking 5B. Overall, these results can be utilized to guide future transcriptome analyses to identify candidate genes that confer HM tolerance in wheat.
Multi-element lenslet array for efficient solar collection at extreme angles of incidence
Authors: Alsaigh Rakan E. , Bauer Ralf , Lavery Martin P. J. 
Published: May 2020

AbstractPhotovoltaics (PV) are a versatile and compact route to harness solar power. One critical challenge with current PV is preserving the optimal panel orientation angle with respect to the sun for efficient energy conversion. We experimentally demonstrate a bespoke multi-element lenslet array that allows for an increased power collection over a wide field of view by increasing the effective optical interaction length by up to 13 times specifically at large angles of incidence. This design can potentially be retrofitted onto already deployed amorphous silicon solar panels to yield an increased daily power generation by a factor of 1.36 for solar equivalent illumination. We 3D printed an optical proof of concept multi-element lenslet array to confirm an increase in power density for optical rays incident between 40 and 80 degrees. Our design indicates a novel optical approach that could potentially enable increased efficient solar collection in extreme operating conditions such as on the body of planes or the side of buildings.
Inequalities in birth weight and maternal education: a time-series study from 1996 to 2013 in Brazil
Authors: Silvestrin Sonia , Hirakata Vânia Naomi , da Silva Clécio Homrich , Goldani Marcelo Zubaran 
Published: May 2020

AbstractMaternal education represents one of the most important social determinants of inequality in birth weight (BW) in developing countries. The present study sought to investigate secular trends in health inequality considering the difference in mean BW between extremes of maternal educational attainment in Brazil. Using a time-series design, data from 6,452,551 live births which occurred in all Brazilian state capitals from 1996 to 2013 were obtained from the Information System on Live Births. Secular trends of the difference in mean birth weight between low (<8 years of schooling) and high (≥12 years of schooling) educational attainment were analyzed. The main finding was that differences in mean birth weight between the two extremes of maternal educational attainment decreased over time. There was a significant decrease in mean BW in neonates born to mothers with higher educational attainment, and a slight increase in those born to mothers with lower educational attainment. One of the key factors involved in decreasing inequality was an increase in the number of antenatal visits. In view of these results, we conclude, that despite a slight increase of mean birth weight among mothers with low education, the reduction of inequality in pregnancy outcomes over time in Brazil is attributable to a worsening scenario for mothers who are better off rather than to improvements for the most vulnerable group of mothers.
Even Bad Social Norms Promote Positive Interactions
Authors: Kamijo Yoshio , Kira Yosuke , Nitta Kohei 
Published: May 2020

AbstractSocial norms for cooperation are often supported by positive and negative sanctions. Simultaneously, positive interactions in human relationships via sanctions are promoted by positive social behavior. This study investigates the relationship between social behavior and sanctions based on economic laboratory experiments. Participants with unique IDs make decisions on the contribution to public goods, which is inefficient for society. After participating in the public goods game, they decide whether to use the sanctions. The type of sanctions are varied, such as no sanction, only punishable, only rewardable, and all of these are possible. We found that inefficient social behavior increases under conditions where participants can reward each other and that the level of social activity and rewards are positively correlated. To exclude the possibility of the participants misunderstanding inefficiency, we performed an additional experiment that emphasizes the meaning of inefficiency that the contribution toward public goods reduces profits in society as a whole. We found that even with this emphasis, the high level of contributions is sustained when sanctions are possible. A group-level comparison showed that the group that maintained bad norms used the reward option more. Our results suggest that people maintain bad norms in anticipation of positive interaction.
Low-frequency noise induced by cation exchange fluctuation on the wall of silicon nitride nanopore
Authors: Matsui Kazuma , Goto Yusuke , Yanagi Itaru , Akahori Rena , Fujioka Michiru , Ishida Takeshi , Yokoi Takahide , Nakagawa Tatsuo , Takeda Ken-ichi 
Published: May 2020

AbstractNanopore-based biosensors have attracted attention as highly sensitive microscopes for detecting single molecules in aqueous solutions. However, the ionic current noise through a nanopore degrades the measurement accuracy. In this study, the magnitude of the low-frequency noise in the ionic current through a silicon nitride nanopore was found to change depending on the metal ion species in the aqueous solution. The order of the low-frequency noise magnitudes of the alkali metal ionic current was consistent with the order of the adsorption affinities of the metal ions for the silanol surface of the nanopore (Li <Na <K < Rb <Cs). For the more adsorptive alkaline earth metal ions (Mg and Ca), the low-frequency noise magnitudes were as low as those for Li ions. This tendency, i.e., metal ions having a very high or low adsorption affinity causing a reduction in low-frequency noise, suggests that the low-frequency noise was induced by the exchange reactions between protons and metal ions occurring on the silanol surface. In addition, the low-frequency noise in the ionic current remained low even after replacing the CaCl2 aqueous solution with a CsCl aqueous solution, indicating that Ca ions continued being adsorbed onto silanol groups even after removing the aqueous solution.
On the use of a continuous thrust to find bounded planar trajectories at given altitudes in Low Earth Orbits
Authors: de Almeida Allan Kardec , Piñeros Jhonathan Orlando Murcia , Prado Antonio Fernando Bertachini de Alme 
Published: May 2020

AbstractIn this work, it is shown how a spacecraft equipped with a thrust and subjected to a drag force can be bounded at specific altitudes as function of the parameters of the thrust. It is used nonlinear dynamics tools to find attractors, which bound the motion of the spacecraft. For a specific set of parameters of the thrust, the spacecraft is bounded to a given altitude. Several forms for the thrusts are proposed in order to bound the altitude of the spacecraft. The influence of several forms of perturbations in the altitude of the spacecraft is also investigated in this work, like the solar radiation pressure, gravity of the Moon and oblateness of the Earth. Finally, nonlinear dynamics tools are also used to investigate transfers among the bounded orbits in different altitudes.
Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
Authors: Huang Gang , Xu Junbo , Zhang Tingjie , Cai Lin , Liu Hanxiong , Yu Xiuqiong , Wu Jing 
Published: May 2020

AbstractHyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.
Interactive effect of sleep duration and sleep quality on risk of stroke: An 8-year follow-up study in China
Authors: Ji Ailing , Lou Heqing , Lou Peian , Xu Chunrong , Zhang Pan , Qiao Cheng , Yang Qing 
Published: May 2020

AbstractInappropriate sleep duration and poor sleep quality are associated with risk of stroke, but their interactive effect on stroke is unknown. We explored the interactive effect of sleep quality and duration on stroke risk. A prospective cohort study was conducted with 41,786 adults. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Sleep duration was measured by average hours of sleep per night. Cox regression models were used to calculate the association of sleep duration and quality with stroke. The delta method and a non-conditional logistic regression model were used and the relative excess risk due to interaction (RERI), the attributable proportion (AP), and the synergy index (S) were calculated. Compared with sleep duration 6–8 h/day, the risk ratio of stroke was 1.63 (1.23–2.11) times for sleep duration <6 h/day and 1.40 (1.08–1.75) times for >8 h/day. The stroke risk ratio was 2.37 (1.52–3.41) times in subjects with poor sleep quality compared with those with good sleep quality. Women who slept <6 h/day had higher stroke risk than men who slept <6 h/day. Men who slept >8 h/day had higher stroke risk than women who slept >8 h/day. Men with poor sleep quality had higher stroke risk than women with poor sleep quality. Stroke was associated with short/long sleep duration and poor sleep quality in subjects aged >46 years, compared with those aged 18–45 years. Stroke occurred more frequently in subjects with poor sleep quality combined with short sleep duration (odds ratio: 6.75; 95% confidence interval (CI): 2.45–14.12). RERI, AP, and S values (and their 95% CIs) were 5.54 (3.75–8.12), 0.72 (0.56–0.80), and 5.69 (4.23–9.90) for the poor sleep quality interact with short sleep duration. In persons with poor sleep quality accompanied by long sleep duration, RERI, AP, and S (95% CI) were 1.12 (1.01–1.27), 0.35 (0.26–0.51), and 2.05 (1.57–2.96), respectively. Subjective sleep disturbances are related with risk of stroke in Chinese adults. There are additive interactions between short/long sleep duration and poor sleep quality that affect risk of stroke.
Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana
Authors: Sako Kaori , Futamura Yushi , Shimizu Takeshi , Matsui Akihiro , Hirano Hiroyuki , Kondoh Yasumitsu , Muroi Makoto , Aono Harumi , Tanaka Maho , Honda Kaori , Shimizu Kenshirou , Kawatani Makoto , Nakano Takeshi , Osada Hiroyuki , Noguchi Ko , Seki Motoaki 
Published: May 2020

AbstractChemical priming is an attractive and promising approach to improve abiotic stress tolerance in a broad variety of plant species. We screened the RIKEN Natural Products Depository (NPDepo) chemical library and identified a novel compound, FSL0260, enhancing salinity-stress tolerance in Arabidopsis thaliana and rice. Through transcriptome analysis using A. thaliana seedlings, treatment of FSL0260 elevated an alternative respiration pathway in mitochondria that modulates accumulation of reactive oxygen species (ROS). From comparison analysis, we realized that the alternative respiration pathway was induced by treatment of known mitochondrial inhibitors. We confirmed that known inhibitors of mitochondrial complex I, such as rotenone and piericidin A, also enhanced salt-stress tolerance in Arabidopsis. We demonstrated that FSL0260 binds to complex I of the mitochondrial electron transport chain and inhibits its activity, suggesting that inhibition of mitochondrial complex I activates an alternative respiration pathway resulting in reduction of ROS accumulation and enhancement of tolerance to salinity in plants. Furthermore, FSL0260 preferentially inhibited plant mitochondrial complex I rather than a mammalian complex, implying that FSL0260 has a potential to be an agent for improving salt-stress tolerance in agriculture that is low toxicity to humans.
Improving lifespan automation for Caenorhabditis elegans by using image processing and a post-processing adaptive data filter
Authors: Puchalt Joan Carles , Sánchez-Salmerón Antonio-José , Ivorra Eugenio , Genovés Martínez Salvador , Martínez Roberto , Martorell Guerola Patricia 
Published: May 2020

AbstractAutomated lifespan determination for C. elegans cultured in standard Petri dishes is challenging. Problems include occlusions of Petri dish edges, aggregation of worms, and accumulation of dirt (dust spots on lids) during assays, etc. This work presents a protocol for a lifespan assay, with two image-processing pipelines applied to different plate zones, and a new data post-processing method to solve the aforementioned problems. Specifically, certain steps in the culture protocol were taken to alleviate aggregation, occlusions, contamination, and condensation problems. This method is based on an active illumination system and facilitates automated image sequence analysis, does not need human threshold adjustments, and simplifies the techniques required to extract lifespan curves. In addition, two image-processing pipelines, applied to different plate zones, were employed for automated lifespan determination. The first image-processing pipeline was applied to a wall zone and used only pixel level information because worm size or shape features were unavailable in this zone. However, the second image-processing pipeline, applied to the plate centre, fused information at worm and pixel levels. Simple death event detection was used to automatically obtain lifespan curves from the image sequences that were captured once daily throughout the assay. Finally, a new post-processing method was applied to the extracted lifespan curves to filter errors. The experimental results showed that the errors in automated counting of live worms followed the Gaussian distribution with a mean of 2.91% and a standard deviation of ±12.73% per Petri plate. Post-processing reduced this error to 0.54 ± 8.18% per plate. The automated survival curve incurred an error of 4.62 ± 2.01%, while the post-process method reduced the lifespan curve error to approximately 2.24 ± 0.55%.
A new concept for the genesis of felsic magma: the separation of slab-derived supercritical liquid
Authors: Taniuchi Hajime , Kuritani Takeshi , Yokoyama Tetsuya , Nakamura Eizo , Nakagawa Mitsuhiro 
Published: May 2020

AbstractFelsic magmas produced at subduction zones have played an important role in the generation and evolution of the continental crust. For the origin of felsic magmas, processes such as fractional crystallization of mafic magmas, partial melting of crustal materials, partial melting of subducting slabs, and partial melting of pyroxenitic mantle wedge components have been proposed. Recent experimental studies have predicted that felsic melt can also be produced in the mantle wedge by the separation of slab-derived supercritical liquid beyond depths corresponding to the critical point. To date, however, the presence of felsic magma of this origin has not yet been reported. In this study, we investigated dacitic lavas and preceding calc-alkaline andesite lavas from the Rishiri Volcano, located at the rear of the Kuril arc. We show that hydrous felsic melt and aqueous fluid were separated from slab-derived supercritical liquid in the mantle wedge. The former erupted as dacitic magma whilst the aqueous fluid induced the generation of primary basaltic magma involved in creating calc-alkaline andesite magma. We infer that slab-derived supercritical liquid is an efficient transport medium for moving silicate-rich components from subducting slabs to the Earth’s surface, and that this process may have contributed to the growth of the continental crust.