bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reframing research access
Authors: Mamtora Jayshree , Pandey Prashant 
Published: November 2020

PurposeThe paper describes how Charles Darwin University (CDU) used a three-pronged approach to better serve its researchers: it developed a single interface for improved accessibility and discoverability of its research outputs, consolidated its corresponding policies and procedures and implemented training programs to support the new portal. This in turn made its suite of research outputs more openly accessible and better discoverable. The intention was to make CDU research compliant with the FAIR (Findable, Accessible, Interoperable and Reusable) policy statement, affirming the need to make Australia's research more visible, thereby enabling better access, better collaboration locally and internationally and researchers more accountable to their community.Design/methodology/approachThis paper uses case study methodology and a qualitative approach.FindingsCDU Library collaborated with the University’s Research Office in undertaking a series of strategies towards reframing access to its research. The partners migrated their research collections into a single, new, integrated interface; developed new policies and consolidated existing ones; and to this end, rolled out a training and educational program for the research community. The intention of the program was to introduce the Pure repository to new researchers and to train all staff to self archive and curate their own research outputs. This new streamlined approach ensured a more comprehensive and timely availability and accessibility of the University's research outputs.Originality/valueA single source of truth was established through the migration of iCDU’s research collections, ensuring data quality was maintained. At the start of this project, there were few institutions in Australia using the Pure system, and even fewer using it as their sole repository for displaying research outputs.
Organization member action proximity and attributions for managerial crisis response failure
Authors: Carson Jack , Waddingham Jacob , Mackey Jeremy 
Published: November 2020

PurposeThe purpose of this research is to describe organization members' attributions for managerial responses to obviously externally caused crises. The authors draw from attribution theory research and the actor-observer bias to argue that organization members' proximity to managerial crisis response is a key determinant of organization members' affective and behavioral outcomes following a crisis.Design/methodology/approachThe authors develop a conceptual dual-process model of attributions that explains why organization members' judgments of managerial responsibility and associated outcomes differ depending on organization members' proximity to crisis response action.FindingsThe authors focus on organization members' attributions for the failure of managerial crisis responses to obviously externally caused crisis events. The authors present propositions regarding the impact of organization members' potential biases on their attributions for managerial crisis response. Then, the authors delineate how action proximity can assuage negative outcomes of managerial crisis response failure by encouraging an attitude of understanding and awareness of situational challenges.Originality/valueThe authors diverge from prior applications of attribution theory to crisis management by focusing on organization members' attributions of managerial crisis response failure, rather than attributions for the initial cause of the crisis itself. The authors also extend prior work that primarily focuses on crisis response strategies by instead elaborating on how organization members' attributions operate in the wake of their management's failure to effectively respond to an obviously externally caused crisis.
Friends or Foes? Bilateral Relationships and Ownership Choice in Cross‐border Acquisitions by Emerging Market Firms
Authors: Yoon Hyungseok (David) , Peillex Jonathan , Buckley Peter J. 
Published: November 2020

AbstractEmerging market firms (EMFs) are increasingly recognized as a heterogeneous group of business enterprises, providing a unique context for examining the predictive power of existing theories. Drawing on real options and internalization theories, this paper predicts the contrasting effect of bilateral relationships on EMFs' ownership choice in cross‐border acquisitions. The conflicting conjectures are tested using data consisting of almost 1,000 cross‐border acquisition deals. Our results show that weak economic, political and military relationships between acquiring and target countries induce EMFs to opt for full acquisitions. The findings support the view of internalization theory, highlighting that EMFs prefer full ownership over partial ownership by coping with the political risk derived from weak bilateral relationships.
Progressing policy toward a risk/need informed sanctioning model
Authors: D'Amato Christopher , Silver Ian A. , Newsome Jamie , Latessa Edward J. 
Published: November 2020

Research SummaryThis study examined whether risk/need assessment results coincided with the placement of defendants into six types of sanctions among convicted adults from 11 counties in one state. Crosstabulations highlighted that individuals’ risk/need levels corresponded to the placement of low‐risk/need individuals to probation and high‐risk/need individuals to prison; however, intermediate sanctions were rarely used for any risk/need level and some low‐ and moderate‐risk/need individuals were sentenced to prison when convicted of offenses that do not typically result in incarceration.Policy ImplicationsThe results suggest that courts should adopt an evidence‐informed sanctioning model by using risk/need assessments to inform sentencing decisions. Further, states should utilize intermediate sanctions more often to divert individuals convicted of less serious offenses from prison. Finally, judges should avoid sentencing low‐risk/need individuals to prison whenever possible. These changes could help courts to better match individuals’ risk/need level to sanctions.
MiR‐423‐5p aggravates lung adenocarcinoma via targeting CADM1
Authors: Huang Yuzhen , Feng Ganzhu 
Published: November 2020

BackgroundAt present, microRNAs and its downstream genes have been regarded as influential indicators in various malignancies. Therefore, the aim of this study was to explore the relationship and molecular mechanism of the miR‐423‐5p and its downstream gene CADM1 in the LUAD.MethodsThe pcDNA‐CADM1 was used to construct the CADM1 overexpressed cell model. The cell proliferation was determined by CCK‐8 and EdU assays and the cell metastasis was performed by wound scratch and transwell chamber assays. The relationship between miR‐423‐5p and CADM1 were determined by bioinformatics, luciferase reporter and western blot assays.ResultsThe results revealed that the CADM1 was downregulated in LUAD tissues and cell lines. CADM1 overexpression markedly repressed the cell proliferation, migration and invasion. Moreover, the results of bioinformatics, luciferase reporter and WB assays showed that CADM1 was a target gene of miR‐423‐5p and the miR‐423‐5p expression was negatively associated with CADM1 in LUAD cell lines. Finally, rescue experiments revealed that downregulation of CADM1 could antagonize the functions of miR‐423‐5p inhibitor on cell proliferation and metastasis. These results indicated that miR‐423‐5p aggravated lung adenocarcinoma via downregulation of CADM1 expression.ConclusionsDownregulation of CADM1 could antagonize the functions of miR‐423‐5p inhibitor on cell proliferation and metastasis. miR‐423‐5p aggravated lung adenocarcinoma via downregulation of CADM1 expression.
Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients
Authors: Andersen Nina Gjerde , Mowinckel Marie‐Christine , Sunde Kjetil , Sandset Per Morten , Beitland Sigrid 
Published: November 2020

AbstractBackgroundThe aim of this study was to evaluate the utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit (ICU) patients.MethodsProspective observational study of ICU patients receiving dalteparin prophylaxis at Oslo University Hospital in Norway. Trough and peak antithrombin, protein C, anti‐factor Xa activity (aFXa), d‐dimer, thromboelastography, calibrated automated thrombogram and microparticles were analysed. Levels were compared in patients with and without venous thromboembolism (VTE), major bleeding, acute kidney injury (AKI) with use of renal replacement therapy (RRT) and variable dalteparin dose.ResultsAmong 50 included patients (76% male, mean age 62 years) five (10%) developed VTE and eight (16%) major bleeding. Median through aFXa level was 0.03 (0.02‐0.05) IU/mL, and 48 (96%) of patients were within and two (4%) above target range. Peak aFXa level was 0.21 (0.13‐0.29) IU/mL, the number of patients below, within and above prophylactic range were 21 (42%), 25 (50%) and four (8%). Peak aFXa levels were similar in patients with and without VTE (0.18 vs 0.21 IU/L, P = .72), major bleeding (0.22 vs 0.21 IU/mL, P = .38) and AKI with RRT (0.18 vs 0.24, P = .13), but lower in patients receiving dalteparin 5000 IU od compared to 7500 IU od (0.19 vs 0.30 IU/mL, P < .01).ConclusionsIntensive care unit patients receiving dalteparin prophylaxis had half of patients within prophylactic peak aFXa target range. Peak aFXa levels was affected by administered dalteparin dose, but not presence of VTE, major bleeding or AKI with RRT.
Basophils and their effector molecules in allergic disorders
Authors: Miyake Kensuke , Shibata Sho , Yoshikawa Soichiro , Karasuyama Hajime 
Published: November 2020

AbstractBasophils are the rarest granulocytes which represent <1% of peripheral blood leukocytes. Basophils bear several phenotypic similarities to tissue‐resident mast cells and therefore had been erroneously considered as blood‐circulating mast cells. However, recent researches have revealed that basophils play nonredundant roles in allergic inflammation, protective immunity against parasitic infections and regulation of innate and acquired immunity. Basophils are recruited to inflamed tissues and activated in an IgE‐dependent or IgE‐independent manner to release a variety of effector molecules. Such molecules, including IL‐4, act on various types of cells and play versatile roles, including the induction and termination of allergic inflammation and the regulation of immune responses. Recent development of novel therapeutic agents has enabled us to gain further insights into basophil biology in human disorders. In this review, we highlight the recent advances in the field of basophil biology with a particular focus on the role of basophils in allergic inflammation. Further studies on basophils and their effector molecules will help us identify novel therapeutic targets for treating allergic disorders.
First‐trimester maternal serum biomarkers and the risk of cerebral palsy
Authors: Peris Monique , Reid Susan M , Dobie Stephen , Bonacquisto Leo , Shepherd Daisy A , Amor David J 
Published: November 2020

AimTo investigate whether combined first‐trimester screening (cFTS) biomarkers are associated with cerebral palsy (CP) and to identify CP characteristics associated with abnormal biomarker levels.MethodIn this retrospective case–control data linkage study, we matched mothers of 435 singletons with CP from a population register to their cFTS records and selected 10 singleton pregnancy controls per case. We compared mean and abnormal levels (expressed as multiples of the median [MoMs]) of pregnancy‐associated plasma protein‐A (PAPP‐A), beta subunit of human chorionic gonadotrophin (β‐hCG), and nuchal translucency between cases and controls and between CP subgroups.ResultsCompared with control pregnancies, CP pregnancies had lower mean levels of PAPP‐A (0.95 vs 1.01 MoM, p=0.02) and β‐hCG (0.93 vs 0.99 MoM, p=0.02). Biomarker levels in CP pregnancies were 1.8 times more likely to be associated with abnormally low levels of PAPP‐A (p<0.01), 1.4 times for β‐hCG (p=0.12), and 2.6 times for low PAPP‐A and β‐hCG together (p=0.04). In cases with CP, an abnormally low PAPP‐A level was associated with moderate preterm birth, low Apgar scores, and Gross Motor Function Classification System level V. Low β‐hCG was associated with very low birthweight.InterpretationLow first‐trimester biomarker levels suggest a role for early pregnancy factors in some causal pathways to CP.What this paper adds

Low first‐trimester levels of biomarkers in maternal serum are associated with later cerebral palsy (CP).

Early pregnancy factors have potential importance in causal pathways to CP.

Causal pathways involving preterm birth, term neonatal encephalopathy, and genetic syndromes may be implicated.
Factors associated with survival and racing performance of 114 Thoroughbred foals with septic arthritis compared with maternal siblings (2009‐2015)
Authors: O’Brien Thomas J. , Rosanowski Sarah M. , Mitchell Keith D. , Carrick Joan B. , Butt Troy D. , Adkins Angus R. 
Published: November 2020

AbstractBackgroundThere is little consensus on factors associated with survival in foals with septic arthritis and limited data on long‐term racing performance of Thoroughbred foals treated for septic arthritis. A more thorough understanding of short‐ and long‐term outcome is necessary to help inform owners, and subsequently guide treatment.ObjectivesTo investigate factors associated with survival, and to analyse racing performance of foals with septic arthritis compared with their maternal siblings.Study designRetrospective cohort and a case‐control study.MethodsVeterinary clinical records of Thoroughbred foals ≤180 days old that underwent arthroscopic, cannulae or through‐and‐through needle lavage for the treatment of septic arthritis between 2009 and 2015 were reviewed. Data included signalment, and clinicopathological information. The dam's foaling records were reviewed and the lifetime racing records were obtained for affected foals and two of their maternal siblings. Logistic regression analysis was used to determine factors associated with survival to discharge or racing. Comparisons between treated foals and their maternal siblings were made.ResultsNinety (78%) of 115 foals diagnosed with septic arthritis were discharged alive. Foals <26 days old at the time of admission were five times less likely (P = .003) and foals with concurrent multisystemic disease were six times less likely (P = .02) to be discharged alive. Sixty (67%) foals discharged alive started in ≥1 race, and there was no difference in the proportion of foals that started in a race or racing performance between foals treated for septic arthritis and their maternal siblings.Main limitationsRetrospective study design, limited number of foals with multiple joint involvement and failure to accurately record duration of clinical signs.ConclusionsFoals treated for septic arthritis at the Scone Equine Hospital, New South Wales, Australia had a good prognosis for survival, and for this cohort, foals that survived to discharge had a similar ability to race as their maternal siblings.
Gamifying the foreign language classroom for brain‐friendly learning
Authors: Rueckert Daniel , Pico Karina , Kim Daesang , Calero Sánchez Ximena 
Published: November 2020

AbstractNew instructional models for learning are emerging as alternatives to traditional education. Gamified instruction is touted as a motivational alternative for learning that increases learner autonomy, but research is lacking into its educational merit beyond those claims. This study measured the extent to which a gamified English as a foreign language classroom adhered to 21 principles of good education proposed by Mind, Brain, and Education (MBE) researchers in comparison to a traditional classroom. It also explored the claim that gamification promotes greater learner autonomy. Two sections of a college English class in Ecuador were used in this study. One was gamified and the other used a traditional education model. Both groups completed a 22 Likert Scale item questionnaire which correlated questions with each MBE principle and one question about perceived autonomy. The teacher and the students also provided comments about the experience. The data showed that the gamified group had higher rankings of perceived adherence to all of the 21 principles and a statement about autonomy with 14 of them being significantly higher. The qualitative data also supported the greater perceived adherence to MBE principles and an increase in perceived autonomy amongst students from the gamified group. It was concluded that gamified instruction did provide a learning environment that adhered more closely to proposals made by MBE researchers for good education and did create an atmosphere where students felt greater control of their learning.
Mapping a high‐level overview of information flows in the Dutch declaration chain for medical specialist health care
Authors: van der Voorn Philippe , Brand Nico 
Published: November 2020

AbstractThis study is based on Philippe van der Voorn’s master’s dissertation at the Utrecht University, Department of Science, Information and Computing Sciences. The problem identified was a lack of an integrated information chain and clear governance structure for information flow in the Netherlands’ health care sector. The method of Design Science was followed to construct an overview model of the chain, and towards a business process model that is intuitive for both technical and business users. An initial declaration chain was identified in the literature and presented, to be confirmed and elaborated on via eight interviews at seven different organisations in the medical specialist health care sector. Based on these interviews, the draft overview was adjusted and a Business Process Model and Notation model created that indicates the shared understanding of the data elements and activities between the organisations. The contribution of the overview of the declaration chain, in particular, can help medical specialist staff obtain an understanding of the administrative side of their work, and with a clear information infrastructure lead to better working processes and information quality. F.J.
Selling Arms and Expressing Harm
Authors: Christensen James 
Published: November 2020

AbstractAccording to an argument commonly made by politicians, selling weapons to oppressive and aggressive regimes can sometimes be permissible because the sale renders the victims of these regimes no worse off than they would have been had the sale not been made. We can refer to this argument as the inconsequence argument. My primary aim in this article is to identify one reason why the inconsequence argument will often not succeed in vindicating arms sales to oppressive and aggressive regimes. The inconsequence argument will often not succeed because arms sales to oppressive and aggressive regimes often do make the victims of these regimes worse off than they would have been had the sales not gone ahead. The victims of these regimes are often made worse off in virtue of the fact that arms sales can generate expressed harms, which, unlike some of the material harms often engendered by such sales, are additive (rather than substitutive) in character. As I shall explain, expressed harms are similar to, but also significantly different from, expressive harms. The differences are important because they allow us to construct a reply that can answer the inconsequence argument on its own (consequentialist) terms.
Equilibrium reproductive strategy of the peacock bass Cichla kelberi facilitates invasion into a Neotropical reservoir
Authors: Soares Guedes Gustavo Henrique , Gomes Iracema David , Alves do Nascimento Aparecida , Silva de Aguiar Fernanda , Araújo Francisco Gerson 
Published: November 2020

AbstractThe reproductive strategy of the non‐native predator cichlid Cichla kelberi was determined to explain its success after more than 60 years of being introduced into an isolated reservoir in southeastern Brazil. This was one of the first‐known translocations of the genus Cichla out of its natural range. Macro‐ and microscopy characteristics of the gonadal development stages and the maturation phases, along with the reproductive features (size at first maturation size, gonado‐somatic index and sex ratio), were described. It was hypothesized that the stable conditions of the reservoir, with low connectivity, weakly defined spatial gradient and slight seasonal changes in environmental variables, favour the equilibrium strategy that enables predators to have high offspring survivorship because of great parental investment in individual progeny. Sex ratio was well balanced, with males and females reaching first maturity between 30.0 and 28.6 cm total length (LT), respectively. The stages of oocyte (primary and secondary growth, vitellogenic and atresia) and spermatocyte (spermatogonia, spermatocytes, spermatids and spermatozoa) development were identified. Five phases of gonadal development (immature, developing, spawning capable, regressing and regenerating) were described for both sexes. A long reproductive season was found, with spawning peaks in August/September and, to a lesser extent, in April/May. Parental care and spawns in parcels (batch spawns) corroborated the raised equilibrium strategy that was effective in this isolated reservoir. This species developed reproductive mechanisms that fit to different environmental conditions, with multiple spawning being associated with lentic environments and asynchronous development of oocytes, which are released over long periods. The reproductive plasticity in reservoirs may be one of the main factors inherent to the successful of colonization and establishment of the peacock bass in the environments in which they were introduced.
Nicotiana benthamiana LRR‐RLP NbEIX2 mediates the perception of an EIX‐like protein from Verticillium dahliae
Authors: Yin Zhiyuan , Wang Nan , Pi Lei , Li Lei , Duan Weiwei , Wang Xiaodan , Dou Daolong 
Published: November 2020

AbstractVerticillium wilt diseases caused by the soil‐borne fungus Verticillium dahliae result in devastating yield losses in many economically important crops annually. Here, we identified a novel ethylene‐inducing xylanase (EIX)‐like protein, VdEIX3, from V. dahliae, which exhibits immunity‐inducing activity in Nicotiana benthamiana. In vitro‐purified VdEIX3 can induce strong oxidative burst, activate the expression of defense‐related genes, and increase resistance against oomycete and fungal pathogens in N. benthamiana. VdEIX3 orthologs of other Verticillium pathogens also induce cell death in N. benthamiana, which form a new type of EIX protein family that is distinct from the known EIX proteins. A leucine‐rich repeat receptor‐like protein, NbEIX2, regulates the perception of VdEIX3 in N. benthamiana. Our results demonstrate that VdEIX3 is a novel EIX‐like protein that can be recognized by N. benthamiana NbEIX2, and also suggest that NbEIX2 is a promising receptor‐like protein that is potentially applicable to transgenic breeding for improving resistance to Verticillium wilt diseases.
Anatomopathological lesions of infection caused by Platynosomum illiciens (Braun, 1901) in Neotropical primates kept in captivity
Authors: Pereira Washington Luiz Assunção , Conga David Marcial Fernandez , da Silva Klena Sarges Marruaz , da Silva Reinaldo José , Imbeloni Aline Amaral 
Published: November 2020

AbstractThis study described the hepatobiliary anatomopathological lesions associated with trematode Platynosomum illiciens parasitism in Neotropical primates kept in captivity. In the evaluated organs, we observed portal fibrosis, biliary epithelial hyperplasia, and inflammatory reaction with a predominance of lymphocytes and plasmocytes, and in some cases infiltration of eosinophils and neutrophils.