bluuebunny/crossref_metadata_2025_split huggingface dataset:
K’u’x como vínculo corporal en el cosmos
Authors: Hinojosa Servando Z. 
Published: June 2020

Para los mayas kaqchikeles del altiplano guatemalteco, el vocablo k´u´x cobra gran importancia en la actualidad. Traducido generalmente como 'corazón', k´u´x conlleva fuerte sentido de fuerza vital. En la comunidad bajo estudio, k´u´x se manifiesta de tres maneras significativas: como enfoque de vida y sensibilidad, como la placenta y como la divinidad creadora sustentadora. En sus múltiples aspectos de muestra un caácter espiritual entre laudo con las dimensiones físicas de la vida humana. El objeto de este ensayo es intentar un entendimiento integral de k´u´x, tomando en cuenta su ubicación en varios dominios de la experiencia maya. Planteo la cualidad fundamental de k´u´x como vínculo corporal en el mundo espiritual maya.
A review of accurate phase measurement methods and instruments for sinewave signals
Authors: Balestrieri Eulalia , De Vito Luca , Picariello Francesco , Rapuano Sergio , Tudosa Ioan 
Published: June 2020

<p class="Abstract">The phase measurement of sinewave signals is important in several applications, such as electric and electronic instrumentation; telecommunications; and optical interferometry. The uncertainty of the phase measurement has an essential role in ensuring the suitable performance of the devices and systems used by the relevant application. Some highly accurate phase measurement methods have been developed and implemented in different instrument types that are currently available on the market or have been proposed in the scientific literature, each capable of covering very different frequency ranges. This article presents an overview of these methods and instruments in order to highlight the characteristics in terms of the measurement uncertainty of the main methods and instruments that are used, by taking into account a varying operative frequency range. The standard deviations considered in the surveyed literature are used to identify a phase measurement method that is capable of covering a large high-frequency range, simultaneously maintaining a low value of measurement uncertainty, as requested by some applications (like waveform recorder frequency response testing).</p>
Paleotopography controls weathering of Cambrian-age profiles beneath the Great Unconformity, St. Francois Mountains, SE Missouri, U.S.A.
Authors: Pevehouse Katie J. , Sweet Dustin E. , Šegvić Branimir , Monson Charles C. , Zanoni Giovanni , Marshak Stephen , Barnes Melanie A. 
Published: June 2020

ABSTRACT
Precambrian (1.4 to 1.5 Ga) granite and rhyolite in the St. Francois Mountains at the northeast corner of the Ozark Plateau in Missouri has been altered down to a depth up to 8 meters below the Great Unconformity (the contact between Paleozoic sedimentary rock and underlying Precambrian). Petrographic, geochemical, and mineralogic data indicate that at least two events generated this alteration: 1) surficial weathering due to subaerial exposure of the granite before Cambrian burial—this material is preserved as a paleosol; and 2) alteration due to reaction with basinal fluids channeled along the unconformity from nearby sedimentary basins long after burial by Paleozoic strata. To assess the variation between surficial weathering and basinal fluid alteration, we measured and sampled for petrologic, geochemical, and mineralogic data in the rock at and just below the Great Unconformity at three paleoelevations. Whole-rock geochemical oxide and X-ray diffraction data indicate that K-metasomatism and highly crystalline illite occurred in each profile. The K increase reflects crystallization of authigenic feldspar and illite from basinal fluids that were channeled along the Great Unconformity during younger Paleozoic fluid-flow events. Each profile also exhibits an upward increase in altered feldspar crystals and highly crystalline kaolinite, and an upward decrease in Ca and Na. Such changes reflect soil formation due to reaction with meteoric water before Cambrian burial, indicating that the altered granite was a paleosol before Paleozoic basinal fluid-flow events. Notably, the paleosol at the highest paleoelevation displays the least amount of paleoweathering and the paleosol at the lowest displays the greatest amount of paleoweathering. These results demonstrate that not only can characteristics of the paleosol just below the Great Unconformity be recognized in the St. Francois Mountains, despite subsequent alteration, but also it is possible to detect variations in soil thickness that were controlled by slope steepness and, therefore, water availability and/or soil creep or failure. This spatial relationship is compatible with studies of modern soils which indicate that soil character varies with position on a slope.
Quantification of Phase Behavior for Solvent/Heavy-Oil/Water Systems at High Pressures and Elevated Temperatures with Dynamic Volume Analysis
Authors: Chen Zehua , Zhao Zulong , Yang Daoyong 
Published: June 2020

SummaryAccurate quantification of phase behavior of solvent/heavy-oil/bitumen/water systems at high pressures and elevated temperatures is of high significance for the design of vapor extraction, cyclic solvent injection, expanding-solvent steam-assisted gravity drainage (ES-SAGD), and hot-solvent injection processes. The relevant experimental data and theoretical analyses are still insufficient for achieving a reliable model. This is especially true when the system temperatures approach or exceed the critical temperatures of the solvents used (i.e., when the solvent density is large enough).This study provides new experimental measurements of the phase behavior of propane (C3H8)/carbon dioxide (CO2)/heavy-oil/water systems at pressures up to 20 MPa and temperatures up to 432.3 K. More specifically, four feeds of C3H8/CO2/heavy-oil/water systems are used to conduct constant composition expansion (CCE) tests, during which the heights of the entire fluid system (i.e., total volume) and each phase are recorded at each pressure and temperature, respectively. Theoretically, a dynamic volume analysis (DVA) of the measured data is proposed for the first time to quantify each phase, provided that the assumption for vapor phase is valid and that the vapor and oleic phase densities can be accurately calculated. By tuning the binary interaction parameter (BIP) for solvent/heavy-oil pairs (denoted as BIPS−HO) to match the total volume, the height of the vapor/oleic (V/L) interface can be matched as well. By using the tuned BIPS−HO, the total volume and height of the V/L interface of C3H8/CO2/heavy-oil/water systems can be accurately predicted, no matter whether the solvent solubility in water is low (i.e., C3H8) or high (i.e., CO2). This DVA can be used to determine/evaluate the solvent solubility, saturation pressure/phase boundary, and phase volume/density accurately in a large temperature and pressure range. The newly proposed DVA method is also used to reproduce the experimental measurements collected from the literature, including phase-volume fractions, solvent solubility, and saturation pressure. In addition, the DVA method can serve as a tool to check whether the experimental measurements are reliable or not.
Mortality in free-ranging Eurasian brown bears (Ursus arctos arctos) in Spain '1998-2018'
Authors: Balseiro Ana , Royo Luis José , Gayo Elena , Balsera Ramón , Alarcia Olga , Marín Juan Francisco García 
Published: June 2020

Abstract
Background: This work summarizes the mortality cases of twenty-five free-ranging Eurasian wild brown bears (Ursus arctos arctos) from the Cantabrian mountain range submitted for necropsy in Asturias and Castilla y León (northwestern Spain) from ' 1998 to 2018'. Results: Causes of death were classified both caused by (i) "human intervention" or "natural causes" and based on (ii) "infectious" or "non-infectious" etiology. In four cases (16%) it was not possible to determine the cause of death due to the inadequate preservation of collected specimens or insufficient tissue availability. Based on "human intervention" or "natural causes", seven out of the 21 (33.3%) brown bears in which the cause of death could be determined died as a consequence of "human intervention" due to illegal hunting (shooting or snare), handling or strychnine poisoning. In contrast, fourteen (66.7%) brown bears died by "natural causes" due to traumatic lesions (fights, unknown traumas or infanticide), infectious canine hepatitis, neoplasia, or mushroom poisoning. Based on "infectious" or "non-infectious" etiology nine out of the 21 (42.9%) brown bears died due to "infectious diseases", namely gangrenous myositis, infectious canine hepatitis or septicemia. The remaining twelve (57.1%) animals died due to "non-infectious" causes, which included handling, traumatic lesions such as shooting, snare, fighting or infanticide, strychnine poisoning, mushroom poisoning or neoplasia. In six of those cases traumatic lesions caused by human activities or by natural causes were complicated with bacterial infection (clostridiosis and septicemia) which finally caused the death of those animals. Additionally, exertional myopathy was observed in the handled animal and in one bear found in a snare. Conclusions: In a non-hunted population of Eurasian brown bear from the Cantabrian mountain range, main cause of death is attributed to “natural causes” mostly due to traumatic lesions and infectious diseases (primary developed such as infectious canine hepatitis or secondary developed such as clostridiosis or septicemia) which is in contrast to previously reported data for other bear populations.These data are valuable and may help in the conservation and management of this recovering population.
A retrospective study of orthodontic treatment with pre-treatment gingival recessions
Authors: Antanaviciene Guoste , Smailiene Dalia , Baseviciene Nomeda , Zasciurinskiene Egle 
Published: June 2020

Abstract
Background: The development of gingival recessions (GR) after orthodontic treatment (OT) is well described in the literature. However, there is a lack of information about the changes in pre-existing GR during OT. Methods: This retrospective study aimed to examine the change of GR before and after OT. Intraoral photographs of 993 patients treated with fixed appliances between 2005 and 2017 were evaluated. Patients who had at least one GR on the vestibular surface of maxillary/mandibular teeth mesial to first molars were included. GR was measured on good quality plaster models before and after OT. The change of GR (T0-T1) was categorised into the three groups: worsened, did not change and improved (this group consisted of GR, which became better but did not disappear, and fully healed, which disappeared after OT)). The change of GR by ≥0.5 mm was recorded. Statistical analysis was performed using SPSS Statistics (Version 22.0. Armonk, NY, USA). Results: Fifty-one (5.1%) patient had ≥1 GR before OT. Of them, 37 (72.5%) patients were included in the final analysis according to the inclusion criteria. GR before OT was found on 114 buccal/labial surfaces.Significant improvement of mean GR at patient level was found between T0 and T1 (0.45 mm, 95% CI: 0.28, 0.62) (p<0.001). At tooth level the median GR improvement was 0.55 (Q1; Q3: 0.12; 0.96) mm (p<0.001). GR improved in 67 teeth (58.7%), did not change in 41 (36.0%), and worsened in 6 (5.3%). Of the 67 GR, which improved, full healing was observed in 15 (22.4%) teeth. There was a lower chance for GR improvement in cases with pre-treatment open bite (OR 3.35; 95% CI: 1.14, 9.84; p=0.03) and dental Class III patients (OR 2.20; 95% CI: 0.92, 5.28; p=0.03). Conclusions: There was an improvement of GR after orthodontic treatment in most cases. Class III malocclusion and reduced pre-treatment overbite had a negative impact on GR improvement.
Association Between Social Support and Mental Health in Pre-Old and Old Age: Is It Different Depends on the Object? A Cross-Sectional Study
Authors: Li Yaya , Kabayama Mai , Kamide Kei 
Published: June 2020

Abstract
Background The association of social support with mental health for the older adults has been well documented; however, object-specific support was rarely discussed. This study examined the relationships of multiple aspects of social support, especially focusing on objects of social support, across different aging stages. Methods We conducted a self-reported cross-sectional survey in Osaka, Japan in 2013. We analyzed 659 pre-old and 888 old age participants. SF-36v2 was used to measure mental health. Objects of social support was divided into 3 categories (kin, friends, community) with integrating sub-dimensions of social support such as instrumental / emotional social support (function) and provided / received social support (role). Ordinary least squares, controlled for covariates, was carried out to analyze the variation among three objects of social support on mental health in two age groups. Results The results showed a positive association within the pre-old age group but not within the old age group. For the pre-old age group, either emotional or instrumental social support either provided to or received from a community neighbor had a positive association, while emotional social support provided to kin or friends and instrumental support received from friends didn’t show any relation to mental health.Conclusions The relationship between social support and mental health varied by objects and age groups.
Cross-sectional field trial to assess the efficacy of restricted application of deltamethrin 1% ready to use formulation: To adapt and develop cost-effective tsetse control strategy to be applied in Ethiopia
Authors: Bekele Dereje Alemu , Aliyu AhImedin Beshir , Gebregiyorgis Behablom Meharenet , Beyene Tegegn Adugna 
Published: June 2020

Abstract
BackgroundProbability-based observational study design was used to collect the baseline data, data to isolate changes occurring overtime and data on last monitoring in which sampling involved stratified random selection of sampling units, since the surveying area is heterogeneous, at the outset, the area was isolated into subareas (strata) based on vegetation, climate, altitude, land use, distribution of human habitation, etc. into more or less homogeneous. Different trap traps design baited with odor attractants were deployed in a georeferenced locaitons. Then, animals were treated with deltamethrin 1%, using hypodermic syringe, at belly and legs body parts, as 0.06 ml of formulation per 1 kg of body weight which is less by 40% that needed for a whole body treatment regime The data processing was carried out based on quantitative data analyzing methods.Results The result of subsequent monitoring surveys depicted that the overall tsetse mean catch reduced by 78.6% from a mean catch of 17.3 ± 8.6 flies per trap per day of pre-control to 3.7 ± 2.6 flies per trap per day at last monitoring. And the reduction was found statistically significant; p=0.000. Consequentially, the overall mean trypanosome prevalence was dropped from a peak of 63 cases (11.6% ± 3.2) in November 2017 to the current level of 17 cases (3.9% ± 2.3) in June 2019. This resulted in a 66.4% reduction in which the difference was found statistically significant; p=0.000. The overall mean PCV value has also improved by 1.5% from 24.9%±3.2 of the reference data to 26.4% ± 3.4 at last monitoring and the difference was found statistically significant; p=0.002. ConclusionAs the findings of this field trial have proved, generally, insecticide-based control technique is one of the most reliable simplest techniques to rapidly suppress tsetse flies. Its cost effectiveness greatly enhances when it is applied in restricted application scenario. The technique has got a potential not only to reduce the amount of insecticide needed for the whole body application regimen by 40%, but also a potential to adequately suppress tsetse flies consequentially, trypanosomosis.
Predicting Survival for Nasopharyngeal Carcinoma: Development and Validation of Nomograms With Routine Hematological Biomarkers Based on the 8th Edition of AJCC/UICC Staging System
Authors: Liang Yu , Chen Kaihua , Yang Jie , Zhang Jing , Peng Rurong , Yan Chang , Shen Desong , Qu Song , Li Ling , Zhu Xiaodong 
Published: June 2020

Abstract
BackgroundThe 8th edition of AJCC/UICC TNM staging system (TNM system) and the previous nomograms have limitations, therefore we aimed to develop and validate nomograms incorporating routine hematological biomarkers with or without EBV DNA for overall survival (OS) and progression-free survival (PFS). We also evaluated the prognostic role of EBV DNA.Material and Methods1203 patients at our hospital from 2013 to 2016 were retrospectively reviewed and divided into two parts (922 patients for primary cohort and 281 for validation cohort). Nomograms (nomogram with or without EBV DNA) were developed and compared with other models (TNM system alone, TNM system with EBV DNA), via comparison the prognostic role of EBV DNA was evaluated. Internal and external validation were performed. Risk stratification were conducted with recursive partitioning analysis.ResultsThe nomograms with EBV DNA for OS and PFS included sex, age, T category, N category, EBV DNA, albumin, neutrophil to lymphocyte ratio and lactate dehydrogenase. The nomograms without EBV DNA for OS and PFS included the same variables but without EBV DNA. The C-index for nomogram with EBV DNA was 0.715 for OS and 0.705 for PFS. For nomogram without EBV DNA, it was 0.709 and 0.700, respectively. It was 0.639 and 0.636 for TNM system alone and 0.648, 0.646 respectively for TNM system with EBV DNA. The nomograms with or without EBV DNA had better performance than both the TNM system alone and TNM system with EBV DNA, while the TNM system with EBV DNA were better than TNM system alone. The validation cohort indicates great applicability of nomograms. The patients were stratified into 4 risk groups.ConclusionThe nomograms with or without EBV DNA provide better prognostication than the TNM system and also the TNM system with EBV DNA. EBV DNA is valuable in predicting survival, but it is not suggested to incorporate EBV DNA alone to TNM system.
Interaction of TRPV1 and EP3 Receptor in Cough and Bronchopulmonary C-Neural Activities
Authors: Gao Xiuping , Zhuang Jianguo , Zhao Lei , Wei Wan , Xu Fadi 
Published: June 2020

Abstract
Prostaglandin E2 (PGE2)-induced coughs in vivo and vagal nerve depolarization in vitro are inhibited by systemic and local administration of TRPV1 (JNJ 17203212) and prostaglandin EP3 receptor antagonists (L-798106) respectively. These results indicate an interaction of TRPV1 and EP3 receptor in cough responses to PGE2 likely through the vagal sensory nerve. This study aimed to determine whether 1) inhalation of aerosolized JNJ 17203212 and L-798106 affected cough responses to citric acid (CA to mainly stimulate TRPV1) and PGE2; 2) TRPV1 and EP3 receptor morphologically co-expressed and electrophysiologically functioned in the individual of vagal pulmonary C-neurons (cell bodies of bronchopulmonary C-fibers in the nodose/jugular ganglia); and 3) the interaction of the two receptors occurred in these neurons. To this end, aerosolized CA or PGE2 was inhaled by unanesthetized guinea pigs pretreated without or with JNJ 17203212 or L-798106 given in aerosol. Immunofluorescence was applied to identify the expression of the two receptors in vagal pulmonary C-neurons (retrogradely traced by DiI). Whole-cell patch clamp approach was used to detect capsaicin (CAP)- and PGE2-induced currents in the same neurons and determine the effects of the TRPV1 and EP3 receptor antagonists on the currents. We found that PGE2-evoked cough was attenuated by JNJ 17203212 or L-798106 and CA-evoked cough greatly suppressed only by JNJ 17203212. EP3-labeled neurons always co-expressed TRPV1 with a cell size < 20 µm and occupied 1/4 of vagal pulmonary C-neurons. Both CAP- and PGE2-induced currents could be recorded in the individuals of some vagal pulmonary C-neurons. The former was largely inhibited only by JNJ 17203212, while the latter was suppressed by JNJ 17203212 or L-798106. The similarity of the interaction in cough and vagal pulmonary C-neural activity suggests that a subgroup of vagal pulmonary C-neurons co-expressing TRPV1 and EP3 receptor is, at least in part, responsible for the interaction of the two receptors in the cough response to PGE2.
MicroRNA silencing of CNN1 and CNN2 protein family members regulates biology processes in colorectal cancer by targeting the p53 signal pathway
Authors: Huang Fuda , Wei Mingwei , Wang Anmin , Zhang Ya , Qin Zebang , Wu Yi , Li Hua , Gou Junyu , Jian Pu , Guo Houji 
Published: June 2020

Abstract
BackgroundCalponin was first defined as a striated muscle troponin T-like protein that binds actin thin filaments to regulate smooth muscle contraction. There are few studies of CNN1 and CNN2 in colorectal cancer, and the roles these two genes play in colorectal cancer cell lines and the mechanisms by which they act are unknown.MethodsWe used immunohistochemistry to identify expression of the two genes in the cancer tissues. RT-PCR was used to measure expression levels of microRNA. W performed western blots to measure changes in signaling pathways in the context of expression interference.Meanwhile, the same method was used to measure binding relationship between the two genes and key pathway proteins. To determine the relationship between microRNA and gene mRNA, we used the reporter gene method. We used the chi-square and t-test methods to analyze the significance and correlations of the data.Results and conclusionsExpression levels of CNN1 were lower in colon cancer tissues than in normal mucosal tissues. After downregulating CNN1, the cell cycle in colon cancer cell lines progressed quickly, and the expression of related pathway proteins also increased. Expression levels of CNN2 were higher in colon cancer tissues, and its downregulation significantly inhibited cell cycle progression in colon cancer cell lines. We confirmed correlations between the expression of microRNA and CNN2 using data analysis.Bars indicate ± standard errors.*p < 0.05; **p < 0.01 compared with the control. The inhibition of the expression of CNN2 mRNA using microRNA was confirmed using western blot. The combination of the two at the mechanism level was also demonstrated using the reporter gene method.