bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported beta-lactam allergy and the risk of surgical site infection: A retrospective cohort study
Authors: Lam Philip W. , Tarighi Payam , Elligsen Marion , Gunaratne Keith , Nathens Avery B. , Tarshis Jordan , Leis Jerome A. 
Published: January 2020

AbstractObjective:To assess whether a self-reported β-lactam allergy is associated with an increased risk of surgical site infection (SSI) across a broad range of procedures and to determine whether this association is mediated by the receipt of an alternate antibiotic to cefazolin.Design:Retrospective cohort study.Participants:Surgical procedures sampled by an institutional National Surgical Quality Improvement Program database over an 18-month period (January 2017 to June 2018) from 7 surgical specialties.Setting:Tertiary-care academic hospital.Results:Of the 3,589 surgical procedures included in the study, 369 (10.3%) were performed in patients with a reported β-lactam allergy. Those with a reported β-lactam allergy were significantly less likely to receive cefazolin (38.8% vs 95.5%) or metronidazole (20.3% vs 26.1%) and were more likely to receive clindamycin (52.0% vs 0.2%), gentamicin (3.5% vs 0%), or vancomycin (2.2% vs 0.1%) than those without allergy. An SSI occurred in 154 of 3,220 procedures (4.8%) in patients without reported allergy and 27 of 369 (7.3%) with reported allergy. In the multivariable regression model, a reported β-lactam allergy was associated with a statistically significant increase in SSI risk (adjusted odds ratio [aOR], 1.61; 95% confidence interval [CI], 1.04–2.51; P = .03). This effect was completely mediated by receipt of an alternate antibiotic to cefazolin (indirect effect aOR, 1.68; 95% CI, 1.17–2.34; P = .005).Conclusions:Self-reported β-lactam allergy was associated with an increased SSI risk mediated through receipt of alternate antibiotic prophylaxis. Safely increasing use of cefazolin prophylaxis in patients with reported β-lactam allergy can potentially lower the risk of SSIs.
Politicization and conflict in the relationship with the European Union: an analysis of Italian Prime Ministers' parliamentary speeches
Authors: Salvati Eugenio 
Published: January 2020

AbstractIn recent years, the relationship between Italy and the European Union (EU) has worsened due to the emergence of an increasingly negative attitude towards the question of European integration. The growth in citizens' disaffection with, and hostility towards, the political elites is part of a more general trend witnessed throughout the EU. From this point of view, an understanding of whether, and in what way, the role of Prime Minister (PM) has been affected by this change of perspective, especially following the various crises affecting the EU in the last 10 years, would be worthwhile we believe. This article examines the political positions of all PM during the so-called Second Republic (1994–now), by means of a longitudinal content analysis. This analysis reveals that after 2008, and for the first time in the history of the Italy–EU relationship, PMs' speeches have included sharp criticism of the EU. In particular, two PMs (Renzi and Conte) have clearly rejected those conditionality mechanisms implied by the EU. The results of this study confirm the start of a phase of strong conflict/politicization in regard to the EU and its institutional functioning.This article contributes to the broader literature concerning the study of the relationship between political elites and the EU, by focusing for the first time not simply on party leaders but on one of the most important institutional roles in the Italian political system (thePresidenza del Consiglio).
Effect of the different forms of overconfidence on venture creation: Overestimation, overplacement and overprecision
Authors: Vörös Zsófia 
Published: January 2020

AbstractThis paper focuses on the effects of entrepreneurial overconfidence at new venture creation. By analyzing Global Entrepreneurship Monitor data and using the theory of planned behavior as a framework, the study provides new evidence on the relative or absolute nature of overconfidence in entrepreneurial skills and the effect of overprecision on new venture creation. Overprecision of supporting beliefs is newly linked to venture creation and it is shown that nascent entrepreneurs’ overconfidence is based on a self-focusing attitude. The results confirm that overconfidence is not a single construct and highlights the differences between the forms of overconfidence habitually confused in the entrepreneurship literature.
Deterrence Effects: The Role of Authoritarian Leadership in Controlling Employee Workplace Deviance
Authors: Zheng Yuyan , Huang Xu , Graham Les , Redman Tom , Hu Saiquan 
Published: January 2020

ABSTRACTDrawing upon two independent samples from mainland China, we propose and investigate the deterrence function of leadership behavior focused on control. We suggest that controlling leadership, specifically, authoritarian leadership, deters employees’ deviance under certain conditions. That is, authoritarian leadership thwarts employees’ interpersonal deviance behavior when leaders send clear signals of potential punishments of non-compliance by showing low leader benevolence, and when employees are highly dependent on the leaders for important work resources. Results from two independent studies largely support our key propositions. Overall, these results add to the range of possible impacts that a leader can play in decreasing employee deviance. Theoretical implications and directions for follow-up research are discussed.
Pressure Knapping and the Timing of Innovation: New Chrono-Cultural Data on Prehistoric Groups of the Early Holocene in the Maghreb, Northwest Africa
Authors: Perrin Thomas , Dachy Tiphaine , Guéret Colas , Lubell David , Chaïd-Saoudi Yasmina , Green William 
Published: January 2020

ABSTRACTThe early Holocene in North Africa remains a poorly known period, documented unequally by region. Eastern Algeria and Tunisia have the greatest number of deposits, but most were excavated decades ago without the controls and recording required for modern interpretation. The chronological framework is based on radiocarbon (14C) dates that are also old, for the most part. Recent work on Mesolithic lithic industries of Western Europe has enabled us to revive the hypothesis of the existence of contacts between the northern and southern shores of the western Mediterranean at least by the 6th millennium cal BC. A collective research program was conducted in 2016–2017 to test this hypothesis with a particular focus on documenting the technological traditions in the lithic industry and situating them precisely in time. We have 46 new radiocarbon dates that were recently carried out on previously excavated Algerian sites, some of which contain several levels, allowing the construction of Bayesian models. These new measures reinforce the hypothesis of contacts between Europe and Africa by demonstrating the contemporaneity of similar technological processes. Above all, they make it possible to accurately refine the chronology of the main cultural entities of the Maghreb at the beginning of the Holocene.
Compound-Specific Radiocarbon Analysis of Organic Compounds from Mount Fuji Proximal Lake (Lake Kawaguchi) Sediment, Central Japan
Authors: Yamamoto Shinya , Miyairi Yosuke , Yokoyama Yusuke , Suga Hisami , Ogawa Nanako O , Ohkouchi Naohiko 
Published: January 2020

ABSTRACTDifferential sources of sedimentary organic compounds in a volcanic region were revealed by determining radiocarbon content (Δ14C) of organic compounds in surface sediments from Lake Kawaguchi, at the northern foot of Mount Fuji, central Japan. The Δ14C values of C16fatty acid (−124‰) and chlorophylla(Chla) (−133‰) were similar to the Δ14C of dissolved inorganic carbon (DIC) in surface water (−117‰), suggesting that a significant portion of these compounds originated from modern primary producers with a reservoir age of ~1000 years. On the other hand, a large offset between the Δ14C values of Chla(−133‰) and those of 132, 173-cyclopheophorbide-a-enol (−169‰) and pheophytina(−179‰) suggested contributions from older pigments. In addition, the Δ14C of long-chain (C24, C26, and C28) fatty acids (−183 to −75‰) showed a large offset from that of a plant leaf remain (0‰) within sediments, demonstrating that the long-chain fatty acids were affected by substantial contributions from pre-aged terrestrial materials. Overall, the sedimentary organic compounds gave14C ages older than the plant leaf fragment within sediments; however, the similarity between Δ14C of the C16fatty acid and DIC implies potential for applying compound-specific radiocarbon analysis as a dating tool in volcanic lake environments.
Aortopexy for the management of paediatric tracheomalacia – the Alder Hey experience
Authors: Williams S P , Losty P D , Dhannapuneni R , Lotto A , Guerrero R , Donne A J 
Published: January 2020

AbstractBackgroundWhilst aortopexy is an accepted and established procedure, there remains considerable heterogeneity within the literature, with inconsistencies in both the approach taken and the technique employed. Furthermore, limited data exist on both patient selection and long-term outcomes. This study aimed to report the experience of managing severe tracheomalacia by way of aortopexy in a large UK paediatric centre.MethodA retrospective case note review was conducted. Mean follow up was five years.ResultsTwenty-five patients underwent aortopexy for severe tracheomalacia caused by external vascular compression. Acute life-threatening events precipitated investigation in 72 per cent of cases. Twenty-one patients initially presented to ENT services for investigation, which comprised upper airway endoscopy and imaging with computed tomography angiography. Post-operatively, the majority of patients demonstrated complete resolution of symptoms and were discharged from all associated services. Only four patients required a tracheostomy.ConclusionAortopexy offers an effective method of treating severe tracheomalacia due to vascular compression.
A cross-sectional study to determine the energy density and nutritional quality of primary-school children’s lunchboxes
Authors: Sutherland Rachel , Nathan Nicole , Brown Alison , Yoong Serene , Reynolds Renee , Walton Alison , Janssen Lisa , Desmet Clare , Lecathelinais Christophe , Gillham Karen , Herrmann Vanessa , Wolfenden Luke 
Published: January 2020

AbstractObjective:The present study describes the energy content of primary-school children’s lunchboxes and the proportion of lunchbox foods considered discretionary. Subgroup analyses by sex, socio-economic status, age and weight status were undertaken.Design:A cross-sectional study was conducted. Mean kilojoule content, number of items and categorisation of foods and drinks in lunchboxes as ‘everyday’ (healthy) or discretionary (sometimes) foods were assessed via a valid and reliable lunchbox observational audit.Setting:Twelve Catholic primary schools (Kindergarten–Grade 6) located in the Hunter region of New South Wales, Australia.Participants:Kindergarten to Grade 6 primary-school students.Results:In total, 2143 children (57 %) had parental consent to have their lunchboxes observed. School lunchboxes contained a mean of 2748 kJ, of which 61·2 % of energy was from foods consistent with the Australian Dietary Guidelines and 38·8 % of energy was discretionary foods. The proportion of lunchboxes containing only healthy foods was 12 %. Children in Kindergarten–Grade 2 packed more servings of ‘everyday’ foods (3·32 v. 2·98, P < 0·01) compared with children in Grades 3–6. Children in Grades 3–6 had a higher percentage of energy from discretionary foods (39·1 v. 33·8 %, P < 0·01) compared with children in Kindergarten–Grade 2 and children from the most socio-economically disadvantaged areas had significantly higher total kilojoules in the school lunchbox compared with the least disadvantaged students (2842 v. 2544 kJ, P = 0·03).Conclusions:Foods packed within school lunchboxes may contribute to energy imbalance. The development of school policies and population-based strategies to support parents overcome barriers to packing healthy lunchboxes are warranted.
Constraints on the Rheology of the Lithosphere From Flexure of the Pacific Plate at the Hawaiian Islands
Authors: Bellas Ashley , Zhong Shijie , Watts Anthony 
Published: January 2020

AbstractThe rheology of oceanic lithosphere is important to our understanding of mantle dynamics and to the emergence and manifestations of plate tectonics. Data from experimental rock mechanics suggest rheology is dominated by three different deformation mechanisms including frictional sliding, low‐temperature plasticity, and high‐temperature creep, from shallow depths at relatively cold temperatures to large depths at relatively high temperatures. However, low‐temperature plasticity is poorly understood. This study further constrains low‐temperature plasticity by comparing observations of flexure at the Hawaiian Islands to predictions from 3‐D viscoelastic loading models with a realistic lithospheric rheology of frictional sliding, low‐temperature plasticity, and high‐temperature creep. We find that previously untested flow laws significantly underpredict the amplitude and overpredict the wavelength of flexure at Hawaii. These flow laws can, however, reproduce observations if they are weakened by a modest reduction (25–40%) in the plastic activation energy. Lithospheric rheology is strongly temperature dependent, and so we explore uncertainties in the thermal structure with different conductive cooling models and convection simulations of plume‐lithosphere interactions. Convection simulations show that thermal erosion from a plume only perturbs the lithospheric temperature significantly at large depths so that when it is added to the thermal structure, it produces a small increase in deflection. In addition, defining the temperature profile by the cooling plate model produces only modest weakening relative to the cooling half‐space model. Therefore, variation of the thermal structure does not appear to be a viable means of bringing laboratory‐derived flow laws for low‐temperature plasticity into agreement with geophysical field observations and modeling.
Tracking of Tropical Intraseasonal Convective Anomalies: 1. Seasonality of the Tropical Intraseasonal Oscillations
Authors: Singh Bohar , Kinter James L. 
Published: January 2020

AbstractA tracking algorithm based upon a multiple object tracking method is developed to identify, track, and classify Tropical Intraseasonal Oscillations (TISO) on the basis of their direction of propagation. Daily National Oceanic and Atmospheric Administration Outgoing Longwave Radiation anomalies from 1979–2017 are Lanczos band‐pass filtered for the intraseasonal time scale (20–100 days) and spatially averaged with nine neighboring points to get spatially smoothed anomalies over large spatial scales (~105 km2). TISO events are tracked by using a two‐stage Kalman filter predictor‐corrector method. Two dominant components of the TISO (Eastward propagating and Northward propagating) are classified, and it is found that TISO remains active throughout the year. Eastward‐propagating TISO events occur from November to April with a phase speed of ~4 m/s and northward‐propagating TISO events occur from May to October with a phase speed of ~2.5 m/s in both the Indian and Pacific Ocean basins. Composites of the mean background states (wind; sea surface temperature, SST; and moisture) reveal that the co‐occurrence of warm SST and mean westerly zonal wind plays an important role in the direction of propagation and the geographical location of TISO events. In mean state sensitivity experiments with Sp‐CAM4, we have found that the seasonality of TISO in terms of the geographical location of occurrences and direction of propagation is primarily associated with the annual march of the maximum SST and low level zonal wind which tends to follow the SST.
Moho Structure Across the Backarc‐Craton Transition in the Northern U.S. Cordillera
Authors: DiCaprio L. , Maiti T. , Dettmer J. , Eaton D. W. 
Published: January 2020

AbstractIn southern Canada and the northern United States, the present‐day western edge of the North American craton (Laurentia) is marked by a profound change in lithospheric thickness, from
100 km within a hot backarc setting beneath the Cordillera to
200 km beneath the craton. A nearly uniformly flat Moho in the backarc region of southern Canada has been interpreted as a young feature that was produced by lower crustal channel flow. The tectonic environment of the southern Canadian Cordillera extends southward to the Lewis and Clark shear zone in the northern United States, where previously deployed EarthScope Transportable Array stations provide coverage on a
70 km grid. Here, data from Transportable Array stations are used to investigate teleseismic P to S receiver functions of crustal structure across the craton‐backarc transition, coupled with lithospheric structure derived from a recent global tomographic model. These images suggest that, north of the Lewis and Clark shear zone, the shallower Moho beneath the Cordillera has encroached on the craton, creating a narrow complex transition zone. To the south, a step‐like change in crustal thickness is observed, and the complex Moho transition zone is absent. Taken together with other geological and geophysical data, these observations suggest that a young Moho has progressed eastward accompanied by thermal and/or mechanical modification of the Laurentian lithosphere.
A Finite Volume Blowing Snow Model for Use With Variable Resolution Meshes
Authors: Marsh Christopher B. , Pomeroy John W. , Spiteri Raymond J. , Wheater Howard S. 
Published: January 2020

AbstractBlowing snow is ubiquitous in cold, windswept environments. In some regions, blowing snow sublimation losses can ablate a notable fraction of the seasonal snowfall. It is advantageous to predict alpine snow regimes at the spatial scale of snowdrifts (≈1 to 100 m) because of the role of snow redistribution in governing the duration and volume of snowmelt. However, blowing snow processes are often neglected due to computational costs. Here, a three‐dimensional blowing snow model is presented that is spatially discretized using a variable resolution unstructured mesh. This represents the heterogeneity of the surface explicitly yet, for the case study reported, gained a 62% reduction in computational elements versus a fixed‐resolution mesh and resulted in a 44% reduction in total runtime. The model was evaluated for a subarctic mountain basin using transects of measured snow water equivalent (SWE) in a tundra valley. Including blowing snow processes improved the prediction of SWE by capturing inner‐annual snowdrift formation, more than halved the total mean bias error, and increased the coefficient of variation of SWE from 0.04 to 0.31 better matching the observed CV (0.41). The use of a variable resolution mesh did not dramatically degrade the model performance. Comparison with a constant resolution mesh showed a similar CV and RMSE as the variable resolution mesh. The constant resolution mesh had a smaller mean bias error. A sensitivity analysis showed that snowdrift locations and immediate up‐wind sources of blowing snow are the most sensitive areas of the landscape to wind speed variations.
Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients
Authors: Guo Shiwei , Shi Xiaohan , Shen Jing , Gao Suizhi , Wang Huan , Shen Shuo , Pan Yaqi , Li Bo , Xu Xiongfei , Shao Zhuo , Jin Gang 
Published: January 2020

Abstract
Background
About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance of early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles of ctDNA in resectable PDAC and use of ctDNA to identify patients with potential micrometastasis.

Methods
A total of 113 and 44 resectable PDACs were enrolled in discovery and validation cohorts, separately. A panel containing 50 genes was used to screen ctDNA by an NGS-based assessment with high specificity.

Results
In the discovery cohort, the overall detection rate was 38.05% (43/113). Among positive ctDNA, KRAS mutation had the highest detection rate (23.01%, 26/113), while the others were <5%. Survival analysis showed that plasma KRAS mutations, especially KRAS G12D mutation, had significant association with OS and RFS of resectable PDAC. Plasma KRAS G12D mutation showed a strong correlation with early distant metastasis. In the validation cohort, survival analysis showed similar association between plasma KRAS G12D mutation and poor outcomes.

Conclusions
This study demonstrated that plasma KRAS mutations, especially KRAS G12D mutation, served as a useful predictive biomarker for prognosis of resectable PDAC. More importantly, due to high correlation with micrometastasis, preoperative detection of plasma KRAS G12D mutation helps in optimising surgical selection of resectable PDAC.
Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
Authors: Lin Zhibin , Zhang Xuan , Wang Jianlin , Liu Wei , Liu Qi , Ye Yuchen , Dai Bin , Guo Dongnan , Zhang Pengcheng , Yang Peijun , Zhang Ruohan , Wang Lin , Dou Kefeng 
Published: January 2020

AbstractTranslationally controlled tumor protein (TCTP), which is a protein characterized by its potent proliferation promoting activity, has been well studied in the area of growth and tumorigenesis. However, the specific role of TCTP in liver regeneration (LR) and its underlying mechanism remains unclear. In order to investigate the contribution of TCTP during LR, heterozygous TCTP mice were generated, and a mimic LR model was applied to TCTP-knockdown (KD) hepatic cell lines. The results revealed that TCTP-KD impaired LR in mice, and manifested as the following aspects: delayed proliferation of hepatocytes, accompanied by disruption of the mRNA expression of markers of the cell cycle, degenerated lipid metabolism, and abnormal immune response. Furthermore, it was found out that TCTP activated PI3K/AKT signaling by regulating mTORC2. Lastly, the increasing rate of serum TCTP positively correlated to the recovery of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after liver resection in humans. In summary, the present study is the first to reveal the crucial role of intracellular TCTP in LR.