bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of geriatric dermatoses in a rural based tertiary care hospital in South India
Authors: G Rajesh , B N Raghavendra 
Published: April 2020

Dermatological problems in the geriatric population are common and often underestimated.A few studies are available on the dermatologic diseases in this population. Hence, this study is undertaken to evaluate the spectrum of skin changes in the elderly population.This study was conducted in the Department of Dermatology, Sri Devaraj Urs Medical College, attached to RL Jalappa Hospital, Kolar, Karnataka, India. A total of 300 patients were recruited for this study, among them 185 (61.6 %) were males and 115 (38.4%) were females. All the patients aged more than 60 years with skin disorders attending the dermatology OPD were included in the study. A detailed physical and clinical examination was performed for all the study subjects. Patients with genodermatoses, albinism, premature aging and inherited disorders of DNA which may interfere with chronological aging skin were excluded from the study.Out of 300 patients, 185 cases (61.6%) were males and 115 cases (38.4%) were females. Pruritus was the commonest complaint in 186 patients (62%). Among the chronological changes of aged skin, wrinkling was the commonest manifestation observed in 282 (94%) cases. The most commonly observed diseases were eczematous dermatitis in 133 (44.3%) cases, followed by infections and infestations in 122 (40.6%) and papulo-squamous diseases in 33 (11%). A total of 46 (15.3%) patients were found to have papulo-squamous disorders. Psoriasis vulgaris was observed in 21 (7%) cases. Among premalignant and malignant disorders, 4 (1.3%) cases had actinic chelitis, 2 (0.6%) cases of basal cell carcinoma and 1 (0.3%) case of squamous cell carcinoma. A total of 5 patients had connective tissue disorders. The comorbid conditions included hypertension in 49 (16.3%) cases, followed by diabetes mellitus in 31 (10.3%) and 5 (1.6%) patients had hypothyroidism.Dermatological findings in geriatric population are universal and cause considerable morbidity. This would necessitate the need for conducting an exclusive evaluation for these patients.
Comparison of Generic (Rolexan) and Brand (Clexan) Forms of Enoxaparin in Critically Ill Patients: A Cross Over, Open Label, Randomized Prospective Clinical Trial
Authors: Ziaie Shadi , Malekmohammadi Hanieh , Sistanizad Mohammad 
Published: April 2020

Backgrounds: Several generic forms of enoxaparin were introduced to the market after expiring the patent of Clexane. But the main problem with generic forms is its bio-equivalency with brand form as a little difference in active ingredients characteristics, could led to significant clinical differences. For evaluating the efficacy of enoxaparin, it is recommended to measure its activity against Anti Xa. The aim of this study was comparison of Anti Xa Activity of Enoxan® versus Clexane ® in critically ill patients with prophylactic doses.
Methods: This was a cross over, open label, randomized prospective study which was performed between September 2016 and December 2017 in intensive care unit of Labbafinezhad hospital, Tehran, Iran. Thirty adult patients, who received enoxaparin for prophylaxis of thromboembolic events, were recruited. Subjects were subsequently randomized to one of the treatment sequences (Generic–brand or brand–generic). The generic drug was enoxaparin sodium 40 mg (4,000 IU anti-FXa/0.4 mL), manufactured by Ronakpharm, Iran; the brand drug was enoxaparin sodium 40 mg (Clexane® 4,000 IU anti-FXa/0.4 mL), manufactured by Sanofi, France.
Results: Anti-Xa activity was assessed with Stago kit. The anti-Xa activity between 0.2 and 0.5 U/mL was defined as prophylaxis. The average Anti-Xa activities of Clexan and Rolexan were 0.3±0.12 and 0.22±0.10, respectively which reveals statistically no significant difference (P: 0.35). Also Anti-Xa activity in 6 and 11 patients in Clexan and Rolexan groups were under 0.2 (P: 0.16).
Conclusion: Our study showed comparable efficacy of prophylactic doses between Clexan and Rolexan in critically ill patients. Further studies in different patient population are recommended.
J Pharm Care 2020; 8(1): 23-25.
Antiviral Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Dyndrome: A Literature Review
Authors: Sharifzadeh Shiva , Elyasi Sepideh , Mohammadpour Amir Hooshang 
Published: April 2020

Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening drug reaction. Fever, rash, lymphadenopathy, eosinophilia, and hepatic involvement are common features. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, some cases of antivirals induced DRESS are available. In this review, we try to summarize studies of antiviral induced DRESS syndrome. The data were collected by searching PubMed, Science Direct, Google Scholar, Scopus, Cochrane database systematic reviews, and Islamic World Science Citation Center (ISC). The Keywords used as search terms were “DRESS syndrome”, “drug-induced hypersensitivity reaction (DIHS)”, “antiviral”, and names of various antiviral agents. Finally, a total of 28 relevant articles up to the date of publication were included for review. Totally, 30 cases of antiviral induced DRESS are reported. European registry on severe cutaneous adverse drug reactions (RegiSCAR) was the usual used clinical diagnostic criteria. Most of the reports were related to, telaprevir. Rash and fever actually occurred in a large number of these patients. Eosinophilia was the most reported hematologic involvement. Liver injury is the most defined type of organ damage. Most of the patients managed with systemic corticosteroids. The death occurred in 1 patient from liver decompensation. The reactivation various viruses especially HHV-6 is reported in 2 Cases. The latency period was between 10 and 330 days after drug administration. It is necessary to perform more studies, especially those focused on the association between DRESS syndrome and viral reactivation and also its effective management.
J Pharm Care 2020; 8(1): 35-47.
EVIDÊNCIA CIENTIFICA DOS CUIDADOS DE ENFERMAGEM FRENTE AO PACIENTE COM CARCINOMA ORAL
Authors: Lucena Erlivânia Aparecida de , Pereira Vanessa Mandu , Rodrigues Kazia Lena Martinele Lopes da Silva , Nascimento Jackson Jhonatan Vieira do , Araújo Natália Fonseca de , Fonsêca Luiza de Marilac Alves da , Souza Neto Vinicius Lino de 
Published: April 2020

Objetivo: Identificar as evidências cientifica dos cuidados de enfermagem frente ao paciente com carcinoma oral. Método: Trata-se de uma revisão Sistemática, em que buscou-se por estudos nas bases de dados Pubmed, Scopus, Cinahl, Web of Science, Lilacs, Bdenf e Cochrane, por pesquisas voltadas aos cuidados primários para prevenção do carcinoma oral. Os estudos foram analisados de forma pareada e classificado a sua melhor evidencia cientifica. Resultados: A partir da análise dos estudos foi evidenciado que alguns cuidados de enfermagem apresentam resultados significativos, diante do quadro de dor, prevenção de infecção e o autocuidado, como o autoexame da orofaríngea e adjacências, que deve ser realizada continuadamente, Higiene oral com soro fisiológico e clorexidina, a Crioterapia e o uso do chá de camomila. Conclusão: Os cuidados de enfermagem baseados em estudos científicos contribuem para um maior aprimoramento do processo do trabalho, diminuindo riscos, e estimulando habilidades clinicas e acadêmicas.
Cadê a Empresa que Estava Aqui? Processo de Falência e Reestruturação da Kodak à Luz da Teoria do Ciclo de Vida da Firma
Authors: Garcia Inajá Allane Santos , Viana Junior Dante Baiardo Cavalcante , Lucena Wenner Glaucio Lopes 
Published: April 2020

Objetivo: À luz da Teoria dos Ciclos de Vida da Firma, o presente caso de ensino se propõe a apresentar a trajetória percorrida pela Kodak – gigante do mercado fotográfico durante praticamente todo o século XX –, buscando relacionar as características empresariais oriundas das mudanças ocorridas ao longo do tempo com cada um dos estágios do ciclo de vida de uma organização.Método: Os dados para construção do contexto histórico da empresa Kodak foram retirados de diversas fontes da mídia tradicional, priorizando-se o próprio sítio eletrônico da empresa, jornais digitais de alto impacto internacional assim como revistas eletrônicas nacionais. Relevância/originalidade: Este caso de ensino oferece um debate acerca da Teoria dos Ciclos de Vida da Firma, por meio da análise da trajetória de uma empresa real, em um contexto internacional, permitindo a identificação de características empresariais que podem suscitar o ciclo de vida atual de uma organização. Contribuições teóricas/metodológicas: Busca-se ainda uma triangulação entre a Teoria dos Ciclos de Vida da Firma, as características da empresa Kodak e as diversas mudanças ocorridas diante das diversas decisões tomadas no sentido de restruturação da empresa.
B2C E-commerce for Home Appliance in The Brazilian Market: A Cost Efficiency Investigation through a DEA-OCT Model
Authors: Melo Isotilia Costa , Alves Junior Paulo Nocera , Kodama Tatiana Kimura , Silva Karoline Arguelho da , Chimirri Mirian Wawrzyniak , Rebelatto Daisy Aparecida do Nascimento 
Published: April 2020

Objective: to investigate the cost efficiency of inventory management for publicly home appliance retail companies in the Brazilian market that operate, among other channels, with B2C (Business-to-Costumer) and discuss the possible impacts of e-commerce on inventory management. Method: the first step, construction of a descriptive summary of Magazine Luiza and seven other competitors; the second step, analysis of the optimal cost efficiency of companies' inventory management, through an integrated and dynamic model of Data Envelopment Analysis (DEA) and Optimal Control Theory (OCT). Amounts declared in the Quarterly Financial Statements between the fourth quarter of 2010 and the second quarter of 2018 were considered.Main Results: the discovery of best practices and the fact that, despite its extraordinary appreciation, Magazine Luiza was not a reference in inventory management and its costs during the analyzed period as a whole.Relevance/Originality: this article is an initial step to address the lack of studies on e-commerce for emerging markets and inventory management and its costs for e-commerce.Methodological Contributions: the proposition of a methodology that can be used by other researchers to assess the cost efficiency of inventory management and the impact of e-commerce, highlighting best practices.
Experiências de Internacionalização de Pequenas Empresas de Software e Conhecimentos Obtidos
Authors: Gazquez Alessandra Herranz , Machado Hilka Pelizza Vier , Urpia Arthur Gualberto Bacelar da Cruz 
Published: April 2020

Objetivo: o objetivo desta pesquisa foi identificar e analisar as formas de entrada e os conhecimentos obtidos por pequenas empresas de software em experiências de internacionalização.Método: é um estudo qualitativo, realizado com cinco estudos de casos de pequenos empreendedores. Foram utilizados dados primários e secundários. Dados primários foram obtidos em nove entrevistas abertas e semiestruturadas, e os dados secundários em web sites das empresas. Os dados foram categorizados em formas de entrada e conhecimentos obtidos. Os dados desta última categoria foram complementarmente analisados com uso do software Iramuteq. Principais resultados: como conhecimentos gerados, foram identificadas seis classes de conhecimentos, sendo: a) mercados e destinos; b) ação para colocar o produto no mercado internacional; c) apoio e busca de conhecimentos externos; d) necessidade de qualificação para o processo de internacionalização e parcerias locais; e) visão do mercado local; f) complexidade do processo de internacionalização. Relevância/originalidade: o estudo das experiências de internacionalização e conhecimentos obtidos é uma abordagem original, pois destaca as formas de entrada e os conhecimentos obtidos por pequenas empresas de software em experiências de internacionalização. Contribuições teóricas/metodológicas: os resultados mostraram que a aprendizagem nas experiências de internacionalização favoreceu o aumento do conhecimento de mercado internacional e contribuiu para melhoria de competitividade no mercado local.
Follow-Me: Análise dos Construtos que Influenciam na Tomada de Decisão de Seguidores Ligados a Influenciadores Digitais no Contexto Virtual
Authors: Gammarano Igor de Jesus Lobato Pompeu , Souza da Costa Everaldo Marcelo , Gomes Sérgio Castro , Arruda Filho Emilio Jose Montero 
Published: April 2020

Objetivo: O presente estudo tem como objetivo analisar a relação existente entre os construtos Confiança, Boca-a-Boca Eletrônico (E-WOM) e Engajamento com a Tomada de Decisão de consumo dos indivíduos que seguem os Influenciadores Digitais no contexto virtual. Método: O estudo foi desenvolvido a partir de uma abordagem quantitativa exploratória utilizando o Survey com 147 respondentes, onde foi utilizada a técnica da análise fatorial exploratória (AFE), seguido de regressão linear multivariada.Principais Resultados: Os resultados apontam que os construtos Confiança e Engajamento influenciam na Tomada de Decisão de consumo dos seguidores de influenciadores digitais, enquanto Boca-a-Boca Eletrônico (E-WOM) não apresentou significância na relação com a Tomada de Decisão dos indivíduos que seguem os influenciadores digitais.Relevância/Originalidade: Embora confiança, engajamento e Boca-Boca sejam, construtos amplamente testados no marketing quanto ao comportamento de consumo, ainda não se tem evidências de como esses construtos efetivamente são percebidos e se relacionam no contexto dos influenciadores digitais. Portanto, busca-se contribuir com a literatura quanto aos efeitos desses construtos em um ambiente específico do marketing digital, significativamente novo que pode ter efeito no processo de tomada de decisão dos consumidores.Contribuições teóricas/metodológicas: Destaca-se a utilização da AFE como necessário à verificação da existência dos construtos em um novo ambiente de geração de consumo e sua associação com a técnica de regressão multivariada para determinação dos efeitos quanto a tomada de decisão dos consumidores.
Ministério Público, Autonomia Funcional e Discricionariedade: ampla atuação em políticas públicas, baixa accountability
Authors: Oliveira Vanessa Elias de , Lotta Gabriela Spanchero , Vasconcelos Natália Pires de 
Published: April 2020

A literatura nacional já avançou no reconhecimento dos atores do sistema de justiça como atores com poder de veto e de interferência no policy making (Taylor, 2008),por meio de suas decisões, sejam elas judiciais ou extrajudiciais. Os estudos sobre estes atores, contudo, concentra-se especialmente na atuação de juízes, sendo ainda escassos trabalhos voltados para outros membros do sistema de justiça. O presente trabalho visa lançar luz sobre a atuação de promotores do Ministério Público, cuja autonomia e discricionariedade é fator essencial na seleção e condução de casos concretos. Assumindo o pressuposto de que o principal poder discricionário de um promotor de justiça diz respeito à possibilidade de não investigar ou processar, isto é, não dar encaminhamento a alguns casos que lhe chegam ao conhecimento, este trabalho é um primeiro esforço de atender a lacuna teórica apontada. Trata-se de uma pesquisa exploratória, baseada em metodologia qualitativa, por meio da análise de documentos do Ministério Público, em especial as Recomendações do CNMP que tratam sobre autonomia. Demonstramos que a tendência de “autonomia sem accountability” (Kerche, 2007; Kerche et al., 2019), observada desde o início do processo de construção institucional do órgão, não apenas se manteve presente como vem sendo reforçada por atos e normas do CNMP. Por outro lado, não há um movimento institucional no sentido de ampliar a accountability, fazendo com que a atuação de promotores e procuradores seja pouco transparente para além do que está descrito nos processos administrativos ou judiciais. A autonomia é ampla, o controle é baixo.
Walking Exercise Programme (WEP) Menurunkan Cancer Related Fatigue (CRF) Pada Pasien Kanker Payudara Di RSUD. Ibnu Sina Gresik
Authors: Wahyuni Indah Sri , Sudiana I Ketut , Mariyanti Herdina 
Published: April 2020

Introduction: Development of cancer and the side effect of chemotherapy could lead to Cancer Related Fatigue (CRF) in breast cancer patient that getting worse due to inactivation. Hence, exercise was needed. This aimed of this was to analyze the effect of Walking Exercise Program (WEP) to Cancer Related Fatigue.Methode: This study was used quasy experimental design and the population was breast cancer patient undergoing chemotherapy in RSUD Ibnu Sina Gresik in June 2012. The 10 respondents who met inclusion criteria were taken with matching allocation technique and divided into control and case group. CRF were collected by a subjective instrument called Brief Fatigue Inventory (BFI), then analyzed using Wilcoxon signed rank test and Mann Whitney test with signification value was α≤0,05.Result: Result of Wilcoxon signed rank test showed that CRF scale in pre-test was different compared to CRF in post-test of case group (p=0.043). Mann Whitney test showed the comparison of post-test scores in both of groups was different (p=0.009). It can be concluded that WEP has effect to CRF.Discussion: The result showed that WEP could decrease CRF in breast cancer patient undergoing chemotheraphy in RSUD. Ibnu Sina Gresik. It is recommended to apply WEP as one of fatigue management in breast cancer patient undergoing chemotherapy. Further study should use WEP and psychosocial therapy to manage CRF in each fatigue dimension to reduce more scale of fatigue in patient.
Makna Pembangunan Agrowisata Kebun Belimbing Bagi Masyarakat Desa Ngringinrejo, Kecamatan Kalitidu, Kabupaten Bojonegoro
Authors: Nurliana Siti Rena Mei , Putra Dwi Fauzia , Sakdiyah Siti Halimatus 
Published: April 2020

Pembangunan agrowisata dilatar belakangi oleh lahan yang tidak produktif dan atas inisiatif masyarakat, lahan tersebut ditanami belimbing yang kemudian berhasil sampai menjadi agrowisata dan diresmikan pemerintah kabupaten. Agrowisata menjadikan masyarakat terutama petani yang terlibat mengalami perubahan dari kondisi sebelum dengan setelah adanya agrowisata, oleh karena itu masyarakat petani memiliki makna adanya agrowisata yang didasari oleh motif sebab dan motif tujuan. Penelitian ini bertujuan untuk mengetahui: (1) Konteks sosial subjek yang melatar belakangi agrowisata kebun belimbing; (2) Tindakan yang diterapkan subjek dalam Pembangunan Agrowisata Kebun Belimbing; (3) Makna Pembangunan Agrowisata bagi Subjek. Penelitian ini menggunakan metode kualitatif dengan jenis penelitian Fenomenologi. Pengumpulan data yang digunakan dalam penelitian ini adalah wawancara dengan pengelola dan masyarakat petani yang ikut serta mengelola agrowisata dimana pemilihan subjek dilakukan dengan teknik purposive sampling yaitu orang yang paling dianggap tahu tentang apa yang peneliti harapkan. Analisis data dilakukan dengan cara mereduksi, menyajikan dan memverifikasi data. Hasil penelitian ditemukan bahwa: (1) Konteks sosial subjek dilihat dari karakteristiknya yang terdiri dari usia, tingkat pendidikan, beban tanggungan, luas dan status lahan, serta penghasilan yang didapatkan; (2) Tindakan yang diterapkan subjek berupa penanaman, pemeliharaan, pemanenan, dan pasca panen; (3) Makna pembangunan agrowisata bagi subjek yaitu sebagai substitusi ekonomi, untuk memperoleh status sosial organisasi, dan untuk kehidupan anak yang lebih baik. Peneliti selanjutnya disarankan untuk mengkaji strategi dalam mengembangkan agrowisata berbasis pada lingkungan dan partisipasi masyarakat sehingga kesadaran masyarakat akan pentingnya menjaga kelestarian lingkungan semakin tinggi.

Kata kunci: agrowisata, kebun belimbing, fenomenologi, makna, budidaya
SIP SMART: A parallel group randomised feasibility trial of a tailored pre-treatment swallowing Intervention package compared with usual care for patients with head and neck cancer
Authors: Govender Roganie , Smith Christina H , Barratt Helen , Gardner Benjamin , Taylor Stuart 
Published: April 2020

Abstract
Background: Dysphagia or difficulty in swallowing affects quality of life for most patients with head and neck cancer. SIP SMART – [Swallowing Intervention Package: Self-Monitoring, Assessment, Rehabilitation Training] aims to improve post-treatment swallowing outcomes through a targeted and tailored pre-treatment intervention. This feasibility study assessed 1) recruitment and retention, 2) patient acceptability of randomisation and participation, 3) patient adherence, and 4) sought to identify a suitable primary outcome for a definitive trial, including sample size estimation. Methods: This two-arm parallel group non-blinded randomised feasibility trial took place within a head and neck centre at a teaching hospital in London, UK. Patients newly diagnosed with stage III/IV head and neck cancer were recruited and underwent 6-month follow-up. Patients were randomised to SIP-SMART or usual care via an online web-based system. SIP SMART comprised two 45-minute consultations including a baseline clinical and instrumental swallowing assessment, relevant educational information, targeted swallowing exercises, and specific behaviour change strategies to increase exercise adherence. Usual care comprised a single session including a baseline clinical assessment and generic information about the likely impact of treatment on swallowing. Results: A total of 106 patients were identified at pre-screening, 70 were assessed for eligibility. Twenty-six patients did not meet eligibility criteria [0.37, 95% CI 0.27 to 0.49]. Five of 44 [0.11, 95% CI 0.05 to 0.24] eligible patients were not approached by researchers during clinic. Seven [0.18, 95% CI 0.08 to 0.33] of the 39 approached declined participation. Target recruitment (32 consented patients) was achieved within the timeframe. At 6-months 29/32 [0.91, 95% CI 0.76 to 0.97] patients remained in the trial. Acceptability of randomisation and participation in the intervention was favourable, and adherence to the exercises exceeded the pre-defined 35% minimum criterion. The MD Anderson Dysphagia Inventory swallow related quality of life measure was selected as the most suitable primary outcome for sample size estimation. No adverse effects arose from the intervention, or study participation. Conclusions: A definitive trial of the SIP SMART intervention compared to usual care is feasible and can be undertaken with patients with head and neck cancer treated within the NHS.Trial Registration: ISRCTN40215425, registered retrospectively http://www.isrctn.com/ISRCTN40215425