bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing and sustaining national partnerships in professional development and the recognition of open courses in teaching and learning through digital badges
Authors: Donnelly Roisin , Maguire Terry 
Published: November 2020

This article discusses a national partnership in Irish higher education between the National Forum for the Enhancement of Teaching and Learning and the sector. The partnership initiative focussed on the scalable design and development of a suite of open-access professional development (PD) courses in teaching and learning. The empirical work explored the role and value of digital badges as professional recognition for open courses, and in particular the transformative experience of the collaborative course design teams from teachers into teachers-as-designers. Each course has been mapped to Ireland’s national PD framework for all staff who teach. This initiative aimed to provide multiple nationally developed access points to PD opportunities and recognise engagement through digital badges. The partnership with course designers from institutions across Ireland was multifaceted, and their transformation from novice creators of digital content is explored here. Lessons learnt relate to developing consensus on national criteria and associated evidence for scalable open courses, ensuring quality assurance and supporting teams working in partnership. A framework of triple-loop learning was used for conceptualising the different phases of development of the collaborating teams and the sectoral learning around partnerships and nationally recognised collaborative course design.
Implications for practice or policy:

Instructional designers and learning technologists should be included in the development team for early consideration of the concept of badging.
Explicit planning is required, including a course development workshop, provision of templates for designing the course and guides for developing resources.
To ensure rigor, the development team should integrate a peer review process for validating the course content.
Involving human resource and senior managers in exploring PD recognition is vital for sector-wide implementation.
O racjonalnym wykorzystaniu internetu w edukacji
Authors: MORBITZER JANUSZ 
Published: November 2020

Janusz Morbitzer, On the rational use of the Internet in education, Interdisciplinary Contexts of Special Pedagogy, No. 23, Poznań 2018. Pp. 7–21. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2018.23.01
The Internet has become one of the most important educational tools today. However, research shows that it is often used without the necessary reflection, as an easily accessible source of information instead of being a tool for intellectual development. This article presents new opportunities offered by the Internet and new competences that are necessary to fully use the Internet’s potential in education. These competences are mostly intellectual and axiological, not technical.
Od biernego odbiorcy do aktywnego mediakreatora – małe dzieci i TIK w świetle badań własnych
Authors: IWANICKA AGNIESZKA 
Published: November 2020

Agnieszka Iwanicka, Od biernego odbiorcy do aktywnego mediakreatora – małe dzieci i TIK w świetle badań własnych [From passive recipients to active mediacreators: small children and ICT in the light of own studies]. Interdyscyplinarne Konteksty Pedagogiki Specjalnej, nr 23, Poznań 2018. Pp. 143-160. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2018.23.08
Small children show a lot of media activity: they are perfectly capable of handling new technologies, they have been using them since the first years of their life. What activities they show depends on the family home and the behaviors they observe with their parents. With their support and providing positive patterns, the child can become not only a passive media user, but also an active media content creator, a kind of mediacreator, which over time will have a real impact on the reality in which he grows up. In the article, I present some of the results of the my research, in which I checked what role the media plays in the life of a child in an early school age. I try to answer the question, what media activities are displayed by children – whether it is only passive and imitative, or maybe they are actively creating media content.
Nowa jakość kształcenia akademickiego w sytuacji zmiany cywilizacyjnej – interaktywny wykład problemowy
Authors: MORAŃSKA DANUTA 
Published: November 2020

Danuta Morańska, Nowa jakość kształcenia akademickiego w sytuacji zmiany cywilizacyjnej – interaktywny wykład problemowy [The new quality of academic education in the face of a civilisation change – the interactive problem-focused lecture]. Interdyscyplinarne Konteksty Pedagogiki Specjalnej, nr 23, Poznań 2018. Pp. 221-234. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2018.23.13
The article presents important problems that colleges and universities will have to face in order to adapt its didactic offer to the requirements of the present day. The article is based on the research conducted by the author during the training of the researchers and teachers at one of the Polish technical universities.
Nuclear protein in testis midline carcinoma in a Turkish boy: a case report
Authors: Bayrak Büşra Yaprak , Yildiz Demir Kürşat , Demirsoy Uğur , Çorapçioğlu Funda , Anik Yonca , French Christopher A. 
Published: November 2020

Abstract

Background
Nuclear protein in testis (NUT) midline carcinoma (NMC) is an undifferentiated carcinoma, usually localized to the midline and presenting a translocation in the gene for bromodomain containing protein 4. Here, we report a rare case of NMC in an 8-year-old Turkish boy.

Case report
There were masses in the lung, liver, and iliac wing representing metastases. Abdominal lymph node sampling revealed epithelial tumor infiltration with cellular pleomorphism. Immunohistochemistry was strongly positive for cytokeratin and epithelial membrane antigen protein. Because of undifferentiated carcinoma morphology, the tumor was considered to be a NMC. Immunoreactivity with antibodies to NUT and the presence of NUT clarified by fluorescence in situ hybridization (FISH) supported the diagnosis. Despite initial response to chemotherapy, the patient died 7 months after the diagnosis.

Conclusions
Immunoreactivity for NUT antibodies along with a dual-color FISH and karyotype analysis was suggestive for diagnosis of NMC. In differential diagnosis of undifferentiated carcinomas that occur particularly at midline localization, NMC should be considered.
Karl Leonhard Reinholds Begriff der Deduktion
Authors: Lang Stefan 
Published: November 2020

AbstractK.L. Reinhold’s interpretation of deduction plays a seminal role in the development of German Idealism. However, as yet Reinhold’s concept of deduction has not been sufficiently explained. The goals of this paper are (i) to analyze Reinhold’s notion of deduction in hisNeue Darstellung der Hauptmomente der Elementarphilosophie, (ii) to reconstruct his deduction of a priori forms of representation and (iii) to discuss his deduction critically. In doing so, I will present Reinhold’s objections against Immanuel Kant’s method in theCritique of Pure Reason.
Patent Races for COVID-19 Vaccines and Liability Rules
Authors: Kim Jeong-Yoo 
Published: November 2020

Abstract
I analyze a model of patent races for COVID-19 vaccines under alternative liability rules. The first inventor of the vaccine gets the monopoly rent, but must assume full liability from its side effects. In this model, firms choose two kinds of investments, one for inventing a vaccine and the other for its safety. I show that firms have an incentive to overinvest in both activities under strict liability. This is contrasted with the established result established that the injurer takes socially optimal accident-preventing precaution under strict liability. This contrast comes from the competition effect. Overinvestment in inventing vaccines due to competition makes a firm overinvest in safety as well. I also argue that it is undesirable for firms to get full or partial exemption from liability, because it would reduce the incentive to invest in safety. Instead, reducing the monopoly rent by regulating the vaccine price resolves both overinvestment problems.
Existence, multiplicity and nonexistence results for Kirchhoff type equations
Authors: He Wei , Qin Dongdong , Wu Qingfang 
Published: November 2020

Abstract
In this paper, we study following Kirchhoff type equation:

−

a
+
b

∫

Ω

|

∇
u

|

2

d

x

Δ

u
=
f
(
u
)
+
h

in

Ω

,

u
=
0

on

∂

Ω

.

$$\begin{array}{}
\left\{
\begin{array}{lll}
-\left(a+b\int_{{\it\Omega}}|\nabla u|^2 \mathrm{d}x \right){\it\Delta} u=f(u)+h~~&\mbox{in}~~{\it\Omega}, \\
u=0~~&\mbox{on}~~ \partial{\it\Omega}.
\end{array}
\right.
\end{array}$$

We consider first the case that Ω ⊂ ℝ3 is a bounded domain. Existence of at least one or two positive solutions for above equation is obtained by using the monotonicity trick. Nonexistence criterion is also established by virtue of the corresponding Pohožaev identity. In particular, we show nonexistence properties for the 3-sublinear case as well as the critical case. Under general assumption on the nonlinearity, existence result is also established for the whole space case that Ω = ℝ3 by using property of the Pohožaev identity and some delicate analysis.
Uncovering transfer effects of dominance and proficiency in L3 English acquisition using the visual moving window paradigm and grammaticality judgments
Authors: Angelovska Tanja , Roehm Dietmar , Weinmüller Sabrina 
Published: November 2020

Abstract
Using a novel combination of visual moving window paradigm and timed grammaticality judgment task, this study examines how third language (L3) learners (beginners and intermediate) with L2 German and different non-verb-second L1s process violated and non-violated main declarative sentences with fronted adverbials in L3 English. It examines the extent to which so far less-explored predictors (language dominance and proficiency) modulate non-facilitative word order transfer from the L2. Our results from experiment 1 corroborate existing (offline data) results (Angelovska, Tanja. 2017. (When) do L3 English learners transfer form L2 German? Evidence from spoken and written data by L1 Russian speakers. In Tanja Angelovska & Angela Hahn (eds.), L3 syntactic transfer: Models, new developments and implications (Bilingual Processing and Acquisition 5), 195–222. Amsterdam, Philadelphia: John Benjamins; Fallah, Nader & Ali Akbar Jabbari. 2018. L3 acquisition of English attributive adjectives dominant language of communication matters for syntactic cross-linguistic influence. Linguistic Approaches to Bilingualism 8. 193–216) and are in support of a hybrid transfer suggesting that neither proficiency nor dominance plays a role in transfer selection. Results from experiment 2 reveal that L1-dominance was the determining key factor for accuracy performance for low proficiency L3 subjects but higher L3 proficiency tended to neutralize this strong influence - providing evidence for the Scalpel Model (Slabakova, Roumyana. 2017. The scalpel model of third language acquisition. International Journal of Bilingualism 21. 651–665). We explain the contradictory results from the two experiments as a function of task effects.
New Evidence of the Effect of Beijing’s Driving Restriction and Other Olympic-Year Policies on Air Pollution
Authors: Liu Zheng , Kong Haiyang 
Published: November 2020

Abstract
Seven Chinese cities have enacted One-Weekday Limit (OWL) driving restrictions following Beijing’s implementation shortly after the Olympics in 2008. Existing literature examines the short-run effect of the OWL or the long-run effect of the Olympic-year policy package on air pollution in Beijing. Using two difference-in-differences (DD) approaches, this study compares the long-run effect of the Olympic-year policy package with the effect of the OWL. Using the city of Tianjin as a control, this study finds a significant drop in pollution due to the Olympic-year policy package. Using weekends as a control, this study finds a much smaller and less significant drop due to the OWL. These new findings suggest that compared to the OWL, other policies enforced in the Olympic year account for a greater portion of the drop.
Therapeutic effects of coronary granulocyte colony-stimulating factor on rats with chronic ischemic heart disease
Authors: Ren Pengcheng , Zhang Ming , Dai Shuren 
Published: November 2020

AbstractBackgroundThe aim of this study was to evaluate the therapeutic effects of coronary granulocyte colony-stimulating factor (G-CSF) on rats with chronic ischemic heart disease (CIHD).MethodsThirty healthy rats were randomly divided into control, subcutaneous and intracoronary G-CSF injection groups (n = 10) after the CIHD model was established. Left ventricular ejection fraction (LVEF), myocardial injury area, myocardial perfusion area and viable myocardium were observed by coronary angiography, dual-isotopic myocardial imaging and first-pass delayed myocardial perfusion magnetic resonance imaging (MRI) before modeling as well as 2 and 4 weeks after surgery.ResultsThe peak times of peripheral blood and subcutaneous G-CSF levels were 3 and 5 days after mobilization, respectively. The peripheral blood CD34+/CD133+ cell ratio of subcutaneous or intracoronary G-CSF injection group significantly exceeded that of the control group (P < 0.05). The distal stenosis degrees of target lesions in subcutaneous and intracoronary G-CSF injection groups were significantly lower than that of the control group (P < 0.05). Compared with the situation before mobilization, LVEF was significantly improved after 2 weeks in intracoronary and subcutaneous G-CSF injection groups (P < 0.01). Their infarcted myocardial areas were reduced, the left ventricular remodeling was relieved, the percentage of viable myocardium was increased, angiogenesis was promoted and cardiomyocyte apoptosis was inhibited.ConclusionIntracoronary G-CSF injection is safe and effective as subcutaneous injection, improving the cardiac function of CIHD rats.
Monitoring environmental risk of the exotic species Kappaphycus alvarezii (Rhodophyta), after two decades of introduction in southeastern Brazil
Authors: Araújo Patrícia G. , Nardelli Allyson E. , Gelli Valéria C. , Fujii Mutue T. , Chow Fungyi 
Published: November 2020

Abstract

Kappaphycus alvarezii was introduced for mariculture purposes on the coast of São Paulo, southeast of Brazil, in 1995, and since then an experimental pilot cultivation has been maintained. Since it is an exotic species, the dispersion of thallus fragments, presence of reproductive structures and recruitment from spores were monitored bimonthly from November 2016 to January 2018. Fragment dispersion was analyzed on nine selected monitoring sites around the cultivation raft through visual observation and photographic records. To verify the presence of reproductive structures 40 individuals were collected randomly from the cultivation raft and analyzed under a light microscope and stereomicroscope. Reproductive structure recruitment was also evaluated using artificial substrata. The results showed that even 25 years after the introduction of K. alvarezii on the coast of São Paulo, the invasive behavior of this exotic species had not been recorded. There was no evidence of vegetative dispersion and/or establishment in the Ubatuba Bay. Reproductive structures were also not found during the monitoring period. However, we highlight the importance of permanent and systematic environmental monitoring to prevent any impact and to ensure a sustainable aquaculture. These results will contribute to the development of the cultivation of the non-native K. alvarezii in Brazil and to improving public policies of coastal management.
Development of a pregnancy-specific reference material for thyroid biomarkers, vitamin D, and nutritional trace elements in serum
Authors: Boggs Ashley S. P. , Kilpatrick Lisa E. , Burdette Carolyn Q. , Tevis Denise S. , Fultz Zachary A. , Nelson Michael A. , Jarrett Jeffery M. , Kemp Jennifer V. , Singh Ravinder J. , Grebe Stefan K. G. , Wise Stephen A. , Kassim Brittany L. , Long Stephen E. 
Published: November 2020

AbstractObjectivesMatrix differences among serum samples from non-pregnant and pregnant patients could bias measurements. Standard Reference Material 1949, Frozen Human Prenatal Serum, was developed to provide a quality assurance material for the measurement of hormones and nutritional elements throughout pregnancy.MethodsSerum from non-pregnant women and women in each trimester were bottled into four levels based on pregnancy status and trimester. Liquid chromatography tandem mass spectrometry (LC-MS/MS) methods were developed and applied to the measurement of thyroid hormones, vitamin D metabolites, and vitamin D-binding protein (VDBP). Copper, selenium, and zinc measurements were conducted by inductively coupled plasma dynamic reaction cell MS. Thyroid stimulating hormone (TSH), thyroglobulin (Tg), and thyroglobulin antibody concentrations were analyzed using immunoassays and LC-MS/MS (Tg only).ResultsCertified values for thyroxine and triiodothyronine, reference values for vitamin D metabolites, VDBP, selenium, copper, and zinc, and information values for reverse triiodothyronine, TSH, Tg, and Tg antibodies were assigned. Significant differences in serum concentrations were evident for all analytes across the four levels (p≤0.003).TSH measurements were significantly different (p<0.0001) among research-only immunoassays. Tg concentrations were elevated in research-only immunoassays vs. Federal Drug Administration-approved automated immunoassay and LC-MS/MS. Presence of Tg antibodies increased differences between automated immunoassay and LC-MS/MS.ConclusionsThe analyte concentrations’ changes consistent with the literature and the demonstration of matrix interferences in immunoassay Tg measurements indicate the functionality of this material by providing a relevant matrix-matched reference material for the different stages of pregnancy.
Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer
Authors: Chapman Caroline J. , Banerjea Ayan , Humes David J , Allen Jaren , Oliver Simon , Ford Abby , Hardy Katie , Djedovic Natasha , Logan Richard F. , Morling Joanne R. 
Published: November 2020

Abstract

Objectives
Currently, NICE recommends the use of faecal immunochemical test (FIT) at faecal haemoglobin concentrations (f-Hb) of 10 μg Hb/g faeces to stratify for colorectal cancer (CRC) risk in symptomatic populations. This f-Hb cut-off is advised across all analysers, despite the fact that a direct comparison of analyser performance, in a clinical setting, has not been performed.

Methods
Two specimen collection devices (OC-Sensor, OC-S; HM-JACKarc, HM-J) were sent to 914 consecutive individuals referred for follow up due to their increased risk of CRC. Agreement of f-Hb around cut-offs of 4, 10 and 150 µg Hb/g faeces and CRC detection rates were assessed. Two OC-S devices were sent to a further 114 individuals, for within test comparisons.

Results
A total of 732 (80.1%) individuals correctly completed and returned two different FIT devices, with 38 (5.2%) CRCs detected. Median f-Hb for individuals diagnosed with and without CRC were 258.5 and 1.8 µg Hb/g faeces for OC-S and 318.1 and 1.0 µg Hb/g faeces for HM-J respectively. Correlation of f-Hb results between OC-S/HM-J over the full range was rho=0.74, p<0.001. Using a f-Hb of 4 µg Hb/g faeces for both tests found an agreement of 88.1%, at 10 µg Hb/g faeces 91.7% and at 150 µg Hb/g faeces 96.3%. A total of 114 individuals completed and returned two OC-S devices; correlation across the full range was rho=0.98, p<0.001.

Conclusions
We found large variations in f-Hb when different FIT devices were used, but a smaller variation when the same FIT device was used. Our data suggest that analyser-specific f-Hb cut-offs are applied with regard to clinical decision making, especially at lower f-Hb.
Synthesis and efficacy of herbicidal ionic liquids with chlorsulfuron as the anion
Authors: Praczyk Marcin , Wielgusz Katarzyna , Stachowiak Witold , Niemczak Michał , Pernak Juliusz 
Published: November 2020

AbstractIn the framework of this research, four new herbicidal ionic liquids (HILs) comprising chlorsulfuron as the anion were synthesized and characterized. The new salts with chlorsulfuron contained the following cations: tetramethylammonium, didecyldimethylammonium, benzyltrimethylammonium and cholinium. All products were obtained with high yields exceeding 90% via acid–base reaction or ion exchange reaction, by the use of environment-friendly solvents. The structures of all synthesized HILs were confirmed by FT-IR, 1H NMR and 13C NMR analyses. Their efficacy against weeds has been studied under field conditions in fiber flax. All HILs showed herbicidal activity but efficiency was highly dependent on the type of cation and weed species. There were no statistically significant differences in the effectiveness of HILs toward common lambsquarters compared to the reference herbicide, except for salt with cholinium cation that showed significantly lower efficiency. As regards barnyard grass control, all HILs exhibited significantly lower efficacy than that of the reference herbicide, except for didecyldimethylammonium salt that showed similar activity. The synthesized products did not cause damage to flax plants. The obtained results confirmed that the herbicidal effectiveness of the active ingredient (chlorsulfuron) in the form of an ionic liquid can be adjusted by the selection of an appropriate cation in the synthesis.
Schemas and the frequency/acceptability mismatch: Corpus distribution predicts sentence judgments
Authors: Flach Susanne 
Published: November 2020

AbstractA tight connection between competence and performance is a central tenet of the usage-based model. Methodologically, however, corpus frequency is a poor predictor of acceptability – a phenomenon known as the “frequency/acceptability mismatch”. This article argues that the mismatch arises from a “methodological mismatch”, when simple frequency measures are mapped onto complex grammatical units. To illustrate, we discuss the results of acceptability judgments ofgo/come-v. The construction is subject to a formal constraint (Go see the doctor!vs.*He goes sees the doctor), which results from its mandative semantics (directives, commissives). While a formal model makes no prediction with regard to gradient acceptability of bare (“grammatical”)go/come-v, the usage-based view assumes that acceptability is a function of compatibility with an abstract schema. The experimental ratings are compared with a number of corpus-derived measures: while acceptability is largely independent of (raw) frequency, it is not independent of frequency-relatedusage distribution. The results add to recent suggestions that the frequency/acceptability mismatch is substantially reduced if the syntactic complexity of a unit is appropriately captured in usage data.