Dementia in Latin America: Paving the way toward a regional action plan
Authors: Parra Mario Alfredo , Baez Sandra , Sedeño Lucas , Gonzalez Campo Cecilia , Santamaría‐García Hernando , Aprahamian Ivan , Bertolucci Paulo HF , Bustin Julian , Camargos Bicalho Maria Aparecida , Cano‐Gutierrez Carlos , Caramelli Paulo , Chaves Marcia L. F. , Cogram Patricia , Beber Bárbara Costa , Court Felipe A. , de Souza Leonardo Cruz , Custodio Nilton , Damian Andres , de la Cruz Myriam , Diehl Rodriguez Roberta , Brucki Sonia Maria Dozzi , Fajersztajn Lais , Farías Gonzalo A. , De Felice Fernanda G. , Ferrari Raffaele , de Oliveira Fabricio Ferreira , Ferreira Sergio T. , Ferretti Ceres , Figueredo Balthazar Marcio Luiz , Ferreira Frota Norberto Anizio , Fuentes Patricio , García Adolfo M. , Garcia Patricia J. , de Gobbi Porto Fábio Henrique , Duque Peñailillo Lissette , Engler Henry Willy , Maier Irene , Mata Ignacio F. , Gonzalez‐Billault Christian , Lopez Oscar L. , Morelli Laura , Nitrini Ricardo , Quiroz Yakeel T. , Guerrero Barragan Alejandra , Huepe David , Pio Fabricio Joao , Suemoto Claudia Kimie , Kochhann Renata , Kochen Silvia , Kumfor Fiona , Lanata Serggio , Miller Bruce , Mansur Leticia Lessa , Hosogi Mirna Lie , Lillo Patricia , Llibre Guerra Jorge , Lira David , Lopera Francisco , Comas Adelina , Avila‐Funes José Alberto , Sosa Ana Luisa , Ramos Claudia , Resende Elisa de Paula França , Snyder Heather M. , Tarnanas Ioannis , Yokoyama Jenifer , Llibre Juan , Cardona Juan Felipe , Possin Kate , Kosik Kenneth S. , Montesinos Rosa , Moguilner Sebastian , Solis Patricia Cristina Lourdes , Ferretti‐Rebustini Renata Eloah de Lucena , Ramirez Jeronimo Martin , Matallana Diana , Mbakile‐Mahlanza Lingani , Marques Ton Alyne Mendonça , Tavares Ronnielly Melo , Miotto Eliane C , Muniz‐Terrera Graciela , Muñoz‐Nevárez Luis Arnoldo , Orozco David , Okada de Oliveira Maira , Piguet Olivier , Pintado Caipa Maritza , Piña Escudero Stefanie Danielle , Schilling Lucas Porcello , Rodrigues Palmeira André Luiz , Yassuda Mônica Sanches , Santacruz‐Escudero Jose Manuel , Serafim Rodrigo Bernardo , Smid Jerusa , Slachevsky Andrea , Serrano Cecilia , Soto‐Añari Marcio , Takada Leonel Tadao , Grinberg Lea Tenenholz , Teixeira Antonio Lucio , Barbosa Maira Tonidandel , Trépel Dominic , Ibanez Agustin 
Published: November 2020

AbstractAcross Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.