bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic evaluation of palbociclib and its compatibility with other chemotherapies for primary and recurrent nasopharyngeal carcinoma
Authors: Xue Zhichao , Lui Vivian Wai Yan , Li Yongshu , Jia Lin , You Chanping , Li Xin , Piao Wenying , Yuan Hui , Khong Pek Lan , Lo Kwok Wai , Cheung Lydia Wai Ting , Lee Victor Ho Fan , Lee Anne Wing Mui , Tsao Sai Wah , Tsang Chi Man 
Published: November 2020

AbstractBackgroundRecent genomic analyses revealed that druggable molecule targets were only detectable in approximately 6% of patients with nasopharyngeal carcinoma (NPC). However, a dependency on dysregulated CDK4/6–cyclinD1 pathway signaling is an essential event in the pathogenesis of NPC. In this study, we aimed to evaluate the therapeutic efficacy of a specific CDK4/6 inhibitor, palbociclib, and its compatibility with other chemotherapeutic drugs for the treatment of NPC by using newly established xenograft models and cell lines derived from primary, recurrent, and metastatic NPC.MethodsWe evaluated the efficacies of palbociclib monotherapy and concurrent treatment with palbociclib and cisplatin or suberanilohydroxamic acid (SAHA) in NPC cell lines and xenograft models. RNA sequencing was then used to profile the drug response–related pathways. Palbociclib-resistant NPC cell lines were established to determine the potential use of cisplatin as a second-line treatment after the development of palbociclib resistance. We further examined the efficacy of palbociclib treatment against cisplatin-resistant NPC cells.ResultsIn NPC cells, palbociclib monotherapy was confirmed to induce cell cycle arrest in the G1 phase in vitro. Palbociclib monotherapy also had significant inhibitory effects in all six tested NPC tumor models in vivo, as indicated by substantial reductions in the total tumor volumes and in Ki-67 proliferation marker expression. In NPC cells, concurrent palbociclib treatment mitigated the cytotoxic effect of cisplatin in vitro. Notably, concurrent treatment with palbociclib and SAHA synergistically promoted NPC cell death both in vitro and in vivo. This combination also further inhibited tumor growth by inducing autophagy-associated cell death. NPC cell lines with induced palbociclib or cisplatin resistance remained sensitive to treatment with cisplatin or palbociclib, respectively.ConclusionsOur study findings provide essential support for the use of palbociclib as an alternative therapy for NPC and increase awareness of the effective timing of palbociclib administration with other chemotherapeutic drugs. Our results provide a foundation for the design of first-in-human clinical trials of palbociclib regimens in patients with NPC.
Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis
Authors: Cai Jing , Zhang Meng , Liu Yutong , Li Huihui , Shang Longcheng , Xu Tianze , Chen Zhipeng , Wang Fudi , Qiao Tong , Li Kuanyu 
Published: November 2020

Abstract
Background
Macrophages that accumulate in atherosclerotic plaques contribute to progression of the lesions to more advanced and complex plaques. Although iron deposition was found in human atherosclerotic plaques, clinical and pre-clinical studies showed controversial results. Several epidemiological studies did not show the positive correlation between a systemic iron status and an incidence of cardiovascular diseases, suggesting that the iron involvement occurs locally, rather than systemically.

Results
To determine the direct in vivo effect of iron accumulation in macrophages on the progression of atherosclerosis, we generated Apoe−/− mice with a macrophage-specific ferroportin (Fpn1) deficiency (Apoe−/−Fpn1LysM/LysM). Fpn1 deficiency in macrophages dramatically accelerated the progression of atherosclerosis in mice. Pathophysiological evidence showed elevated levels of reactive oxygen species, aggravated systemic inflammation, and altered plaque-lipid composition. Moreover, Fpn1 deficiency in macrophages significantly inhibited the expression of ABC transporters (ABCA1 and ABCG1) by decreasing the expression of the transcription factor LXRα, which reduced cholesterol efflux and therefore promoted foam cell formation and enhanced plaque formation. Iron chelation relieved the symptoms moderately in vivo, but drastically ex vivo.

Conclusions
Macrophage iron content in plaques is a critical factor in progression of atherosclerosis. The interaction of iron and lipid metabolism takes place in macrophage-rich atherosclerotic plaques. And we also suggest that altering intracellular iron levels in macrophages by systemic iron chelation or dietary iron restriction may be a potential supplementary strategy to limit or even regress the progression of atherosclerosis.
The vexing relationship between socioeconomic status and health
Authors: Donahoe J. Travis , McGuire Thomas G. 
Published: November 2020

AbstractIn a recent issue of this Journal, Politzer, Shmueli, and Avni estimate the economic costs of health disparities due to socioeconomic status (SES) in Israel (Politzer et al., Isr J Health Policy Res 8: 46, 2019). Using three measures of SES, the socioeconomic ranking of localities, individual income, and individual education, Politzer and colleagues estimate welfare loss due to higher mortality, productivity loss due to poorer health, excess health care treatment costs, and excess disability payments for individuals with below median SES relative to those with above median SES. They find the economic costs of health disparities are substantial, adding up to between 1.1 and 3.1 billion USD annually—between 0.7 and 1.6% of Israel’s GDP.This paper is useful and informative. It is, to our knowledge, the first comprehensive quantification of the economic costs stemming from health disparities in Israel. In spite of many social policies designed to level economic opportunity and social welfare generally, by most measures, Israel is among the most unequal in the distribution of income among all OECD countries (Cornfeld and Danieli, Isr Econ Rev 12:51–95, 2015). Politzer and colleagues expose the magnitude and sources of health-related loss that Israel faces because of such inequality and shows how the costs of inequality are borne to some degree by all members of society. This short commentary discusses the complicated relationship between SES and health and puts the findings from Politzer and colleagues in the context of the international literature on the subject.
Stakeholder perceptions of non-regulatory bovine health issues in Ireland: past and future perspectives
Authors: Meunier Natascha V. , McKenzie Kenneth , Graham David A. , More Simon J. 
Published: November 2020

Abstract
Background
In recent years, there have been multiple (political, environmental, cultural) drivers of change in Irish agriculture, including the establishment of Animal Health Ireland (AHI) in 2009, to provide leadership of non-regulatory livestock health issues (diseases and conditions of livestock that are endemic in Ireland but which are not currently subject to international legislation). In this study, we describe the opinion of stakeholders (farmers, veterinary practitioners and agricultural industry professional service providers), elicited by means of a survey, on their perceptions of changes in selected non-regulatory bovine health issues over the last 10 years and priority issues relevant to non-regulatory bovine health to be tackled over the next 10 years.

Results
A total of 673 individuals participated in the online questionnaire. For the majority of the non-regulatory bovine health issues, most participants felt there had been improvements over the last 10 years. However, professional service providers were generally more conservative in their response to improvements on-farm compared to farmers. Several issues, particularly BVD and udder health/milk quality, were viewed more positively by all relevant respondents. There was reasonable agreement between responses from different respondent types and sectors regarding the top three priorities relevant to non-regulatory bovine animal health for the next 10 years in Ireland, which included antimicrobial resistance (highlighting measures to reduce both on-farm usage and resistance), anthelmintic resistance, greenhouse emissions and calf welfare.

Conclusions
The results are encouraging, demonstrating a perception of improvement in a number of non-regulatory bovine health issues in Ireland over the last ten years. With respect to the next 10 years, stakeholders prioritised antimicrobial and anthelmintic resistance, greenhouse gas emissions and calf welfare, which aligns closely with broader societal concerns. This information is useful to AHI, particularly with respect to future priorities. However, these concerns are broad in scope and will require further considerations, including collaborations, between AHI and partnering organisations. Given that there were differences between farmers and professional service providers in responses, it is useful to consider how the aims and the benefits of future AHI programmes are framed and communicated to all stakeholders.
Surface deformation evolution in the Pearl River Delta between 2006 and 2011 derived from the ALOS1/PALSAR images
Authors: Li Genger , Feng Guangcai , Xiong Zhiqiang , Liu Qi , Xie Rongan , Zhu Xiaoling , Luo Shuran , Du Yanan 
Published: November 2020

AbstractThis study monitors the land subsidence of the whole Pearl River Delta (PRD) (area: ~ 40,000 km2) in China using the ALOS1/PALSAR data (2006–2011) through the SBAS-InSAR method. We also analyze the relationship between the subsidence and the coastline change, river distribution, geological structure as well as the local terrain. The results show that (1) the land subsidence with the average velocity of 50 mm/year occurred in the low elevation area in the front part of the delta and the coastal area, and the area of the regions subsiding faster than 30 mm/year between 2006 and 2011 is larger than 122 km2; (2) the subsidence order and area estimated in this study are both much larger than that measured in previous studies; (3) the areas along rivers suffered from surface subsidence, due to the thick soft soil layer and frequent human interference; (4) the geological evolution is the intrinsic factor of the surface subsidence in the PRD, but human interference (reclamation, ground water extraction and urban construction) extends the subsiding area and increases the subsiding rate.
Effect of dietary supplementation of seaweed (Ulva lactuca) and Azolla on growth performance, haematological and serum biochemical parameters of Aseel chicken
Authors: Thavasi Alagan Vijayalingam , Nakulan Vatsala Rajesh , Sagadevan Ilavarasan , Subbiah Vairamuthu , Ragothaman Venkataramanan 
Published: November 2020

Abstract
Background
An effort was made to assess the effectiveness of dietary supplementation of Ulva lactuca (U. lactuca), a seaweed and Azolla individually and in combination on different physiological parameters of Aseel chicken. A total of 40 Aseel chicks of 8 weeks old were allocated into four groups, C1 (control), T1 (Azolla alone), T2 (seaweed alone) and T3 (seaweed plus Azolla). Aseel chicks in C1 were fed with formulated grower feed alone, birds in T1 had control diet with 5% Azolla, birds in T2 had control diet with 3% U. lactuca and birds in T3 had control diet admixtured with 5% of Azolla and 3% of U. lactuca. Parameters were recorded for a continuous period of 2 months in 15 days interval.

Results
The growth performance was found to be significant (P ≤ 0.05) during 30 days of feed trials and highly significant (P ≤ 0.01) during 45 and 60 days of treatment. Birds in T3 had a higher body weight gain, shank length and feed conversion efficiency followed with T1 and T2 compared to C1. PCV, RBC, WBC and heterophil counts were not influenced (P ≥ 0.05) by dietary treatments. Uric acid, creatinine, AST, glucose, triglycerides and magnesium levels revealed a high significant (P ≤ 0.01) variation, and cholesterol level showed significant (P ≤ 0.05) changes during 30th and 60th day of feed trials between the control and treatment groups. Total protein, globulin, phosphorus and electrolytes like Na, K and Cl levels were not significant (P ≥ 0.05) during 30th day and were highly significant (P ≤ 0.01) during the 60th day of the trial.

Conclusions
It could be noted that inclusion of U. lactuca and Azolla as feed supplement in grower chicken had a better body weight gain when given in combination (U. lactuca and Azolla) rather than supplemented with the sole entity. Based on the haematological and serum biochemical analysis, the supplementation of U. lactuca and Azolla at the levels included in this trial did not pose any threat to the physiological well-being of Aseel chicken.
Testing the pecking order theory of capital structure: the case of Islamic financing modes
Authors: Guizani Moncef 
Published: November 2020

AbstractThe purpose of this paper is to examine whether or not the basic premises according to the pecking order theory provide an explanation for the capital structure mix of firms operating under Islamic principles. Pooled OLS and random effect regressions were performed to test the pecking order theory applying data from a sample of 66 Islamic firms listed on Kingdom of Saudi Arabia stock market over the period 2006–2016. The results show that sale-based instruments (Murabahah, Ijara) track the financial deficit quite closely followed by equity financing and as the last alternative to finance deficit, Islamic firms issue Sukuk. In the crisis period, these firms seem more reliant on equity, then on sale-based instrument and on Sukuk as last option. The study findings also indicate that the cumulative financing deficit does not wipe out the effects of conventional variables, although it is empirically significant. This provides no support for the pecking order theory attempted by Saudi Islamic firms. This research highlights the capital structure choice of firms operating under Islamic principles. It explores the implication of the relevant Islamic principles on corporate financing preferences. It can serve firm executive managers in their financing decisions to add value to the companies.
Reurbanisation in Postsocialist Europe – A Comparative View of Eastern Germany, Poland, and the Czech Republic
Authors: Haase Annegret , Wolff Manuel , Špačková Petra , Radzimski Adam 
Published: November 2020

Since the 1990s, reurbanisation has become an increasingly frequent trajectory for urban development. Many formerly shrinking cities have been able to stabilise their population or even see new growth. Especially prominent in regions like Germany and the UK, but also observed across the whole continent, a lively debate on reurbanisation has developed as a reality of today’s, and a potential trajectory for tomorrow’s, cities in Europe.Postsocialist Europe has not so far been central in the reurbanisation debate, either empirically or theoretically. Subsequently, the postsocialist experience is missing in the discourse and the existing body of evidence. There is, however, some evidence that Czech and Polish cities are also seeing signs of new inner-city growth and a trend towards core city stabilisation.Against this background, the paper scrutinises the issues of reurbanisation and new growth after the shrinking of postsocialist cities. The paper uses the approach of a contrastive comparison between cities in eastern Germany, where reurbanisation has developed as the predominant trajectory for many large cities, and for cities in Poland and the Czech Republic, where this trend is considerably less prominent. It analyses the development of reurbanisation in these cities and their urban regions over the last few decades, its characteristics and the determinants triggering or impeding it. The paper includes data on a national scale as well as from relevant case studies of cities and their urban regions.It argues, among other things, that there is no “postsocialist model” with regard to influencing factors for reurbanisation. Eastern Germany, due to its specific postsocialist situation and transformation trajectory, can be viewed as an “outlier” or “hybrid” which exhibits characteristics typical of postsocialist and western welfare contexts and which is seeing especially dynamic reurbanisation after a phase of extreme shrinkage. Although there are clear signs of inner-city reurbanisation in Polish and Czech cities as well, it seems relatively unlikely that this process will reach the same high levels as in East German cities within the coming years. * This article belongs to a special issue on reurbanisation.
Fertility Intentions across Immigrant Generations in Sweden. Do Patterns of Adaptation Differ by Gender and Origin?
Authors: Carlsson Erik 
Published: November 2020

In being representative of individuals’ demographic value orientations, fertility preferences provide information about immigrants’ adaptation to family formation patterns in the destination country at a deeper, ideational level than actual fertility does. Using data from Wave 1 of the Swedish GGS from 2012/2013 (n=3,932), this study compares the first, 1.5, and second generations with either one or two foreign-born parent(s) to Swedes without an immigrant background by gender and across origins. Binary logistic regression is used to compare the propensity to state a positive fertility intention, and partial proportional odds models are used to analyse differences across four ordinal intention categories (definitely/probably yes/no). Results show a general tendency towards convergence from the relatively positive intentions of the first generation to levels closer to non-immigrants in later generations, although complete convergence is only found for the second generation with one foreign-born parent. There are gender differences, with women being similar to non-immigrants by the 1.5 generation, while there is no clear intergenerational trend for men. Among origin groups, convergence is evident among Eastern Europeans and “other non-Europeans”, while Westerners already are similar to non-immigrants in the first generation, and Middle Easterners/North Africans display no clear intergenerational trend. This study contributes to the understanding of immigrant fertility by showing that there often is intergenerational adaptation at the ideational (i.e. preference) level, that the pace and extent of convergence vary by gender and across origins, and that group-level patterns found for fertility intentions do not always match those found in earlier research on fertility behaviour.

* This article belongs to a special issue on migrant fertility.
Women’s Attitudes toward Assisted Reproductive Technologies – A Pilot Study among Migrant Minorities and Non-migrants in Germany
Authors: Haug Sonja , Milewski Nadja 
Published: November 2020

This study examines attitudes toward assisted reproductive technologies (ART) among immigrant women and non-migrants in Germany. The social relevance of ART is increasing in Western countries due to overall low birth rates, a high rate of childlessness, and a gap between the desired and the actual numbers of children. Previous literature has been scarce, however, on attitudes toward ART, and immigrant minorities have rarely been included in studies on ART.Our working hypotheses are drawn from theoretical considerations on political socialisation and cultural integration. The analysis is based on data collected in a pilot study in 2014 and 2015. The sample includes 960 women aged 18 to 50 living in Germany. About 81 percent of the sample are immigrants who originate from Turkey, Poland, the Balkan countries, or countries of the (Russian) Commonwealth of Independent States (CIS). We study the social norm to use ART to have a child, the personal attitude of whether a woman would use ART herself, and the methods that they would consider for their own use.Our results show that ART is overall socially acceptable, and the majority of women said that they would use it if necessary. There is significant variation between the origin groups, however. Non-migrants show the lowest acceptance rates and migrants from Poland and Turkey the highest approval. There is also variation in the ART procedures considered for use with the migrants more approving of heterologous methods than non-migrants. The differences between the origin groups diminish only partly when controlling for further explanatory variables, i.e. gender-role attitudes, religiosity, and socio-demographic characteristics of the respondents.We conclude that attitudes toward ART are shaped less by socio-demographic characteristics, but rather by cultural factors and the socialization in the migrants’ countries of origin. The diversity in attitudes toward ART by cultural background should be acknowledged in research and public discourses on ART as well as in regulating policies. * This article belongs to a special issue on migrant fertility.
Prey species and prey selection of dholes at three different sites in Thailand
Authors: CHARASPET KHWANRUTAI , Sukmasuang Ronglarp - , KHOEWSREE NORASET , PLA-ARD MANANYA , CHANACHAI YUWALUK 
Published: November 2020

Abstract. Charaspet K, Sukmasuang R, Khoewsree N, Pla-ard M, Chanachai Y. 2020. Prey species and prey selection of dholes at three different sites in Thailand. Biodiversitas 21: 5248-5262. The study of prey species and prey selection of Dholes at 3 different sites was conducted at Khao Yai National Park, Salak Pra, and Huai Kha Khaeng Wildlife Sanctuaries from 2013 to 2020. Information on Dhole prey at the sites was collected from the residues of dhole scats, from which the selection index, the relative biomass of the prey, and the relative amounts of the consumed prey were calculated. The data were collected simultaneously with the use of camera traps at each site. The study revealed that there were 13 species of Dhole prey with body weight over 5 kg. The result indicated that there were 7 species of even-toed ungulates. The relative biomass of even-toed ungulates ranged between 76.78 - 90.50% of the total biomass of all the Dholes’ consumed prey for all study sites. The dietary diversity index unveiled a similar index in all areas, which proved the adequacy of the analyzed scats. However, the Niche breadth index, which indicates the relevance of prey selection and prey species to the appearances of the prey at each site, was found to be high at Huai Kha Khaeng Wildlife Sanctuary, Khao Yai National Park, while the index was found to be low at Salak Pra Wildlife Sanctuary. The results revealed that Dholes consumed viverrid species and Malayan porcupine more often at the site where there were large carnivores. The recommendation from this study was the conservation and restoration of the ungulate populations, the main prey, as it greatly affects the conservation of the Dhole populations in Thailand. Grassland and salt lick sites, water sources improvements are also important to promote prey population. The conservation of wildlife prey by releasing them to nature, as currently conducted, has an effect on the increase of Dholes’ prey species.