bluuebunny/crossref_metadata_2025_split huggingface dataset:
State‐of‐charge prediction of lithium ion battery through multivariate adaptive recursive spline and principal component analysis
Authors: Vyas Mayank , Pareek Kapil , Spare Shitanshu , Garg Akhil , Gao Liang 
Published: March 2020

AbstractThe main aim of this research work is to provide a comprehensible state of art for the intensification of the utmost decisive task performed by a modern BMS system to monitor and estimate battery states through a well‐entrenched statistical analysis method. In the present work, “multivariate adaptive regression splines” (MARS) method along with principal component analysis (PCA) has been used to develop a predictive model‐based state of charge (SoC) estimator for an NCR 18650PF Lithium ion battery at constant charging c‐rate of 0.3 C and 0.3 C and 0.5 C constant discharge profiles. Time‐weighing factors, that is, voltage‐current and temperature are employed as training datasets, to provide greater impact for developing a SoC MARS model of with high coefficient of correlation R2 (0.9984). The SoC MARS model adequacy is then validated for voltage prediction of the same battery for two different profiles of discharging using NIPALS algorithm for principal component analysis (PCA) with SS2 of 93.69% and 94.23% for profile A and profile B, respectively.
Artificial intelligence in process control applications and energy saving: a review and outlook
Authors: Kramer Alexander , Morgado‐Dias Fernando 
Published: March 2020

AbstractThis work summarizes selected applications of artificial neural networks and related solutions such as neuro‐fuzzy within different control loops such as the network predictive control regarding energy saving. It also shows such applications in the chemical industry and points out why further research on these applications regarding the control of distillation columns might be economically promising, as the world market in the chemical industry is expected to grow from 3.47 trillion euro in 2017 to about 6.6 trillion euro in 2030, the energy consumption might also rise. As not only companies in the chemical industry set up energy saving programs to reduce energy consumption and greenhouse gases, the consumption of energy decreased since 1990 in Europe. Compared to other countries like China, the energy prices in Europe – especially in Germany – have the highest prices due to taxes and governmental issues. Thus, research about applications with artificial intelligence in energy saving holds the promise of economic gain. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Quo Vadis, Macromolecular Science? Reflections by the IUPAC Polymer Division on the Occasion of the Staudinger Centenary
Authors: Abetz Volker , Chan Chin Han , Luscombe Christine K. , Matson John B. , Merna Jan , Nakano Tamaki , Raos Guido , Russell Gregory T. 
Published: March 2020

AbstractWe survey the past, present and future of polymers and macromolecular science, both in general and giving specific examples from our diverse array of research backgrounds within polymer science and technology. As befitting our common bond, we pay some attention to the role of IUPAC. In line with this being part of a Rosarium philosophorum, one might say we conclude that it is Citius, Altius, Fortius for polymers in the century ahead, by which we mean “faster engagement, higher value, stronger properties”, and one should also add “longer usage”. In this way our broad community will continue to build on the century that has passed since Hermann Staudinger launched macromolecular science.
Chemotherapy‐induced peripheral neuropathy among patients with ovarian cancer
Authors: Jin Lin , Zhang Yu , Yang Wenqing 
Published: March 2020

AbstractObjectiveTo evaluate the course of chemotherapy‐induced peripheral neuropathy (CIPN) among patients with ovarian cancer receiving taxanes.MethodsIn a retrospective case–control study conducted between January 1, 2016, and May 31, 2018, in Xiangya Hospital in Changsha, China, women with ovarian cancer received taxane and platinum‐complex combination therapy. The European Organization for Research and Treatment of Cancer Quality of Life, Ovarian cancer module questionnaire, was used to assess the severity of neuropathy by telephone.ResultsOut of the 88 women included in the study, 61 (69.3%) reported CIPN. Twelve months after chemotherapy, the percentage was 19.3%. The percentage of patients suffering from sensory peripheral neuropathy (SPN) was higher than motor peripheral neuropathy at any time during the study. Sensory peripheral neuropathy was associated with the use of docetaxel and paclitaxel (docetaxel vs liposomal paclitaxel: odds ratio [OR] 4.39, 95% confidence interval [CI] 1.69–11.42, P<0.01; paclitaxel vs liposomal paclitaxel: OR 5.91, 95% CI 1.09–31.97, P=0.04). The average weakness score in acute CIPN was lower than chronic CIPN (1.46 vs 2.00, P=0.019). Patients treated with vitamin B1 and amifostine experienced better relief from CIPN.ConclusionThe present study showed a significant proportion of patients with ovarian cancer receiving taxanes suffered from long‐term residual neuropathy, and the use of docetaxel and paclitaxel was associated with SPN. Vitamin B1 or amifostine may improve the symptoms of CIPN.
HbA1c in patients with intracranial meningiomas WHO grades I and II: A preliminary study
Authors: Orešković Darko , Almahariq Fadi , Majić Ana , Sesar Patricija , Živković Marcela , Maraković Jurica , Marčinković Petar , Predrijevac Nina , Vuković Petra , Chudy Darko 
Published: March 2020

AbstractMeningiomas are among the most common primary brain tumors. There is a growing need for novel ways of differentiating between benign (World Health Organization [WHO] grade I) and atypical (WHO grade II) meningiomas as well as for novel markers of the tumor's future behavior. A difference between glucose metabolism in atypical and benign meningiomas is well known. However, a significant correlation between the systemic metabolic status of the patient and the meningioma WHO grade has not yet been established. Our aim was to compare the WHO grades of intracranial meningiomas with the patient's HbA1c levels as a more reliable marker of the chronic systemic metabolic status than the fasting blood glucose value, which is usually looked at. We retrospectively analyzed 15 patients and compared their meningioma WHO grade with their preoperative HbA1c values. Our results show that patients with benign intracranial meningiomas have significantly lower HbA1c value. Conversely, patients with atypical intracranial meningiomas have higher HbA1c values. Furthermore, we showed that the proliferation factor Ki67 was statistically strongly correlated with the HbA1c value (p < .001. These results imply a possible positive correlation between meningioma cell proliferation and the chronic systemic glycemia. Further research in this area could not only lead to better understanding of meningiomas but could have significant clinical application.
Ascites as a Cause of Hyperechogenic Kidneys
Authors: Fontaine Suzanne , Lafortune Michel , Breton Guy , Vallée Claude 
Published: March 2020

AbstractIn 40 patients with ascites, hyperechogenicity of the kidneys was directly proportional to the amount of fluid interposed between the clinically normal kidney and the transducer. The beam‐enhancing phenomenon of ascites on renal parenchymal echogenicity should be distinguished from renal disease causing the increase in parenchymal echoes.
Modeling the upper airway: A precursor to personalized surgical interventions for the treatment of sleep apnea
Authors: Hingley Lachlan , Jeiranikhameneh Ali , Beirne Stephen , Peoples Gregory , Jones Andrew , Sayyar Sepidar , Eastwood Peter , Lewis Richard , Wallace Gordon , MacKay Stuart G. 
Published: March 2020

AbstractAn accurate benchtop model was developed to mimic the different forms of human upper airway collapse in adult sleep apnea patients. This was done via modeling the airway through digital imaging. Airway representative models were then produced in two steps via a customized pneumatic extrusion 3D printing system. This allowed the pressure of collapse and planes of collapse to be manipulated to accurately represent those seen in sleep apnea patients. The pressure flow relationships of the collapsible airways were then studied by inserting the collapsible airways into a module that allowed the chamber pressure (Pc) around the airways to be increased in order to cause collapse. Airways collapsed at physiologically relevant pressures (5.32–9.58 cmH2O). Nickel and iron magnetic polymers were then printed into the airway in order to investigate the altering of the airway collapse. The introduction of the nickel and iron magnetic polymers increased the pressure of collapse substantially (7.38–17.51 cmH2O). Finally, the force produced by the interaction of the magnetic polymer and the magnetic module was studied by measuring a sample of the magnetic airways. The peak force in (48.59–163.34 cN) and the distance over which the forces initially registered (6.8–9.7 mm) were measured using a force transducer. This data set may be used to inform future treatment of sleep apnea, specifically the production of an implantable polymer for surgical intervention.
Role of α‐tocopherol and Lactobacillus plantarum in the alleviation of mercuric chloride‐induced testicular atrophy in rat's model: Implication of molecular mechanisms
Authors: Fadda Laila M. , Alhusaini Ahlam M. , Al‐Qahtani Qamraa H. , Ali Hanaa M. , Hasan Iman H. 
Published: March 2020

AbstractThe present work was aimed to evaluate the protective effects of alpha‐tocopherol (α‐toco) and/or Lactobacillus plantarum (LCB) against testicular atrophy induced by mercuric chloride (MCH). Rats were injected with 5 mg/kg MCH for 5 days consecutively, then treated with 100 mg/kg α‐toco and 6 × 1010 CFU 1.8701/kg LCB alone or together for 3 weeks. The MCH elevated serum TNF‐α, IL‐ 6, caspase‐3, and testicular malondialdehyde. However, serum testosterone, dehydroepiandrosterone, testicular messenger RNA of a steroidogenic acute regulatory protein, 17‐β‐hydroxysteroid dehydrogenase, 3β‐hydroxysteroid dehydrogenase, glutathione level, and superoxide dismutase activity were decreased. Protein expression of Nrf2 was downregulated whereas that of Bax and DNA fragmentation was upregulated in the testicular tissues. Treatment with α‐toco and LCB ameliorated the deviated biochemical parameters and improved tissue injury. It was concluded that the combination of LCB and α‐toco achieved promising results in the amelioration of MCH‐induced testicular atrophy. Nrf2, Bax expressions, and DNA fragmentation are involved in the testicular atrophy induced by MCH.
Computational models of (001) faceted anatase TiO2 nanoparticles
Authors: Vorontsov Alexander V , Valdés Héctor , G Smirniotis Panagiotis , Paz Yaron 
Published: March 2020

AbstractBACKGROUNDUnderstanding the structures and properties of photocatalysts requires the developing of computational quantum models. The present study is devoted to calculating structures, bands positions and location of the HOMO/LUMO orbitals in anatase titanium dioxide (TiO2) nanoparticles comprising of exposed (001) and (100) surfaces of various sizes having different extent of hydroxylation at their edges. The (001) surface was left intact or was reconstructed by introducing an additional row of atoms every four unit cells. Two computational approaches were compared: self‐consistent charge density‐functional tight‐binding (SCC‐DFTB) and PM6.RESULTSThe SCC‐DFTB method was found to be, for most cases, superior to the PM6 method in terms of structure, band positions and electronic orbitals. Based on the SCC‐DFTB approach it was concluded that the presence of the (1 × 4) reconstruction was essential for keeping the (001) surface flat. Otherwise the surface undergoes anisotropic shrinking and bending, which contradicts experimental data. The band gap of the de‐hydroxylated or partially hydroxylated nanoparticles was always smaller than that of nanoparticles with hydroxylated edges. No clear quantum size effects were found for these nanoparticles. Photogenerated non‐thermalized holes were found to localize around (001) facets and at their edges, while electrons tended to concentrate over the central parts of the (100) facets.CONCLUSIONEfficient separation of charge carriers is predicted for anatase nanoparticles having (001) and (100) external surfaces. This conclusion, and moreover, the approach of using SCC‐DFTB calculations to study faceting effects, is likely to be relevant to the developing of new, highly active, photocatalysts as well as for fundamental studies of adsorption. © 2020 Society of Chemical Industry
Optimization of extraction for Anemarrhena asphodeloides Bge. using silica gel‐based vortex‐homogenized matrix solid‐phase dispersion and rapid identification of antioxidant substances
Authors: Ma Tiancheng , Sun Jia , Li Xiangkun , Ma Yukun , Liu Lei , Guo Lina , Liu Qi , Sun Yu 
Published: March 2020

AbstractA novel and simple method was established for the extraction and determination of seven compounds in Anemarrhena asphodeloides Bge. using silica gel‐based vortex‐homogenized matrix solid‐phase dispersion and ultra‐high performance liquid chromatography quadrupole‐time of‐flight mass spectrometer. The conditions for the extraction were optimized. Silica gel was used as the dispersant, 50% methanol–water was selected as an elution solvent and the grinding time was 3 min. Compared with the traditional ultrasonic‐assisted extraction, the developed method was rapid and efficient. In order to screen potential antioxidants, extract dealing with the optimized method was applied to a polyamide chromatography column and a D‐101 macroporous resin column. Fr.2.2 showed the highest antioxidant activities with the most content of flavonoid. A total of 25 peaks were identified from the active fraction. A 2,2′‐diphenyl‐1‐picrylhydrazyl ultra‐high performance liquid chromatography coupled with mass spectrometry approach was adopted for the rapid and exact screening and identification of antioxidant compounds. It indicated that flavonoids exhibited potential antioxidant activities. The antioxidant activities of nine monomeric compounds in vivo were tested. Structure–activity relationships were discussed. Five flavonoids with the concentration of 500 µg/mL would reduce the oxidative stress of PC12 cells that were induced with 2,2′‐azobis[2‐methylpropionamidine] dihydrochloride.
A clinical and experimental study of adult hereditary spherocytosis in the Chinese population
Authors: Xue Jun , He Qing , Xie Xiao‐Jing , Su Ai‐Ling , Cao Shi‐Bin 
Published: March 2020

AbstractHereditary spherocytosis (HS) is often misdiagnosed due to lack of specific diagnostic methods. Our study summarized clinical characteristics and described the diagnostic workflow for mild and moderate HS in Chinese individuals, using data from 20 adults, 8 of whom presented a familial history for HS. We used scanning electron microscopy (SEM) to diagnose HS. We observed reduced eosin maleimide fluorescence activity (5.50 mean channel fluorescence (MCF) units) in the 10 cases of HS, which differed significantly when compared with 10 normal adults (15.50 units), iron deficiency anemia (15.50 MCF units), and megaloblastic anemia (12.00 MCF units) values (P < .05). Next generation sequencing results revealed that 9 out of 10 patients were found to have mutations in the spectrin alpha chain (SPTB), anchor protein (ANK1), and SLC4A1 genes. These mutations were not reported in the Human Gene Mutation Database (HGMD), 1000 human genome, ExAC, and dbSNP147 databases. Splenectomy proved to be beneficial in alleviating HS symptoms in 10 cases. It was found that for the diagnosis of HS, SEM and next generation gene sequencing method proved to be more ideal than red blood cell membrane protein analysis using sodium dodecyl sulfate polyacrylamide gel electrophoresis and western blotting.
Synthesis of Polymer Single‐Chain Nanoparticle with High Compactness in Cosolvent Condition: A Computer Simulation Study
Authors: Zhang Yue‐Yuan , Jia Xiang‐Meng , Shi Rui , Li Shu‐Jia , Zhao Huanyu , Qian Hu‐Jun , Lu Zhong‐Yuan 
Published: March 2020

AbstractPolymeric single‐chain nanoparticles (SCNPs) are soft nano‐objects synthesized by intramolecular crosslinking of isolated single polymer chains. Syntheses of such SCNPs usually need to be performed in a dilute solution. In such a condition, the bonding probability of the two active crosslinking units at a short contour distance along the chain backbone is much higher than those which are far away from each other. Such a reaction condition often results in local spheroidization and, therefore, the formation of loosely packed structures. How to inhibit the local spheroidization and improve the compactness of SCNPs is thus a major challenge for the syntheses of SCNPs. In this study, computer simulations are performed and the fact that a precollapse of the polymer chain conformation in a cosolvent condition can largely improve the probability of the crosslinking reactions at large contour distances is demonstrated, favoring the formations of closely packed globular structures. As a result, the formed SCNPs can be more spherical and have higher compactness than those fabricated in ultradilute good solvent solution in a conventional way. It is believed this simulation work can provide a insight into the effective syntheses of SCNPs with spherical conformations and high compactness.
Loss of myoepithelial calponin‐1 characterizes high‐risk ductal carcinoma in situ cases, which are further stratified by T cell composition
Authors: Mitchell Elizabeth , Jindal Sonali , Chan Tiffany , Narasimhan Jayasri , Sivagnanam Shamilene , Gray Elliot , Chang Young Hwan , Weinmann Sheila , Schedin Pepper 
Published: March 2020

AbstractA hallmark of ductal carcinoma in situ (DCIS) progression is a loss of the surrounding ductal myoepithelium. However, whether compromise in myoepithelial differentiation, rather than overt cellular loss, can be used to predict the risk of DCIS progression is unknown. Here we address this question utilizing pure and mixed DCIS cases (N = 30) as surrogates for DCIS at low and high risk for progression, respectively. We used multiplex immunohistochemical staining to evaluate the relationship between myoepithelial cell differentiation and lymphoid immune cell types associated with poor prognostic DCIS. Our results show that myoepithelial calponin‐1 discriminates between pure and mixed DCIS lesions better than histological subtype, presence of necrosis, or nuclear grade. Additionally, focal loss of myoepithelial cells associated with increased PD‐1+CD8+ T cells, which suggests a link between the myoepithelium and immune surveillance. To identify associations between calponin‐1 expression and immune response, we performed unsupervised hierarchical clustering of myoepithelial and immune cell biomarkers on 219 DCIS lesions from 30 cases. Notably, the majority of pure (low‐risk) DCIS lesions clustered in a high calponin‐1, T cell low group, whereas the majority of mixed (high‐risk) DCIS lesions clustered in a low calponin‐1, T cell high group, specifically with CD8+ and PD‐1+CD8+ T cells. However, a subset of pure DCIS lesions had a similar calponin‐1 and immune signature as the majority of mixed DCIS lesions, which have low calponin‐1 and T cell enrichment—raising the possibility that these pure DCIS lesions might be at a high risk for progression.
Detection screening and seasonality evaluation of hypoplastic left heart syndrome in the polish national registry for fetal cardiac anomalies from the years 2004 to 2016
Authors: Sokołowski Łukasz , Fendler Wojciech , Tobota Zdzisław , Kordjalik Paulina , Krekora Michał , Słodki Maciej , Respondek‐Liberska Maria 
Published: March 2020

AbstractObjectivesTo evaluate the incidence of hypoplastic left heart syndrome (HLHS) and the efficiency of the screening program using data from the Polish National Registry for Fetal Cardiac Anomalies.To investigate whether HLHS incident rates in Poland are seasonally variable.MethodsData on 791 cases of HLHS from the Registry collected between 2004 and 2016 was analyzed.ResultsThe median gestational age for the 734 cases of HLHS detected was 23 weeks. Comparing the age at time of HLHS detection between 2004 and 2016, a decrease from 26 to 20.8 weeks was observed. We noted a rapid increase in HLHS incidence during the initial years of the Registry data, the annual percentage change during that period was 22.0% and this trend lasted until 2010. In the following years, the Registry became representative of the general population which has an estimated incidence of HLHS of 20.93 cases per 100 000 live births. We observed no clear seasonal patterns of HLHS incidence in our population.ConclusionThe Registry reached a plateau state in terms of diagnosing new cases of HLHS. No evidence of seasonality has been noted. The average gestational age of patients identified as having HLHS decreased significantly during the study period.
Lysosomal storage disease spectrum in nonimmune hydrops fetalis: a retrospective case control study
Authors: Al‐Kouatly Huda B. , Felder Laura , Makhamreh Mona M. , Kass Stephanie L. , Vora Neeta L. , Berghella Vincenzo , Berger Seth , Wenger David A. , Luzi Paola 
Published: March 2020

AbstractObjectivesNonimmune hydrops fetalis (NIHF) accounts for 90% of hydrops fetalis cases. About 15% to 29% of unexplained NIHF cases are caused by lysosomal storage diseases (LSD). We review the spectrum of LSD and associated clinical findings in NIHF in a cohort of patients referred to our institution.MethodsWe present a retrospective case‐control study of cases with NIHF referred for LSD biochemical testing at a single center. Cases diagnosed with LSD were matched to controls with NIHF and negative LSD testing and analyzed according to the STROBE criteria to the extent the retrospective nature of this study allowed.ResultsBetween January 2006 and December 2018, 28 patients with NIHF were diagnosed with a LSD. Eight types of LSD were diagnosed: galactosialidosis 8/28 (28.6%), sialic acid storage disease (SASD) 5/28 (17.9%), mucopolysaccharidosis VII 5/28 (17.9%), Gaucher 4/28 (14.3%), sialidosis 2/28 (7.1%), GM1 gangliosidosis 2/28 (7.1%), Niemann‐Pick disease type C 1/28 (3.6%), and mucolipidosis II/III 1/28 (3.6%). Associated clinical features were hepatomegaly 16/21 (76.2%) vs 22/65 (33.8%), P < .05, splenomegaly 12/20 (60.0%) vs 14/58 (24.1%), P < .05, and hepatosplenomegaly 10/20 (50.0%) vs 13/58 (22.4%) P < .05.ConclusionThe most common LSD in NIHF were galactosialidosis, SASD, mucopolysaccharidosis VII, and Gaucher disease. LSD should be considered in unexplained NIHF cases, particularly if hepatomegaly, splenomegaly, or hepatosplenomegaly is visualized on prenatal ultrasound.