bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid Prescribing Trends in Women Following Mastectomy or Breast-Conserving Surgery Before and After the 2014 Federal Reclassification of Hydrocodone
Authors: Gibson Derrick C. , Chou Lin-Na , Raji Mukaila A. , Baillargeon Jacques G. , Kuo Yong-Fang 
Published: December 2019

Abstract

Background
Given concerns about suboptimal pain management for actively treated cancer patients following the 2014 federal reclassification of hydrocodone, we examined changes in patterns of opioid prescribing among surgical breast cancer patients.

Materials and Methods
Data from a large nationally representative commercial health insurance program from 2009 to 2017 were used to identify women aged 18 years and older who were diagnosed with carcinoma in-situ or malignant breast cancer and received breast-conserving surgery or mastectomy from 2010 to 2016. Generalized linear mixed models were used to estimate the adjusted odds ratio (aOR) for receipt of ≥1-day, &gt;30-day, or ≥ 90-day supply of opioids in the 12 months following surgery adjusting for demographics, cancer treatment–related characteristics, and preoperative opioid use.

Results
A total of 60,080 patients were included in the study. Surgically treated breast cancer patients in 2015 (aOR = 0.90, 0.84–0.97) and 2016 (aOR = 0.80, 0.74–0.86) were less likely to receive ≥1-day supply of opioid prescriptions when compared with patients in 2013. Patients who had surgery in 2015 (aOR = 0.89, 0.81–0.98) and 2016 (aOR = 0.80, 0.73–0.87) were also less likely to receive &gt;30-day supply of prescription opioids in the 12 months following surgery. However, only surgical breast cancer patients in 2016 were less likely to receive ≥90-day supply (aOR = 0.86, 0.76–0.98).

Conclusion
Surgically treated breast cancer patients are less likely to receive short- and long-term opioid prescriptions following the implementation of hydrocodone rescheduling. Further studies on the potential impact of federal policy on cancer patient pain management are needed.
ZSM-5 Zeolitinin Yüzey Özelliklerinin Ters Gaz Kromatografisiyle Belirlenmesi
Authors: BİLGİÇ Ceyda 
Published: December 2019

Zeolitler, simektit grubunun mikro gözenekli üyeleridir ve endüstriyel uygulamalarda geniş kullanım alanı bulurlar. Zeolitlerin yüzey, morfolojik, mineralojik ve fizikokimyasal özellikleri farklı aletli analiz teknikleri ile incelenmiştir. Yüzey fonksiyonel grupları Fourier dönüşümlü kızılötesi (FTIR) spektrumları ile belirlenmiştir. Malzemelerin morfolojisi ve yüzey fonksiyonel grupları taramalı elektron mikroskobu (SEM) görüntüleri ve X ışını kırınım desenleri yardımıyla analiz edilmiştir. Zeolitin, Brunauer-Emmett-Teller (BET) yüzey alanı, gözenek hacmi, gözenek büyüklüğü dağılımı ve ortalama gözenek çapı da dâhil gözenek özellikleri, -196 ○C de N2 atmosferinde fiziksel adsorpsiyon ile belirlenmiştir. Zeolit yüzeyini karakterize etmek için ters gaz kromatografisi (TGK) uygulanmıştır. ZSM-5 zeoliti, Yüzey özellikleri, Morfolojik özellikler, Fizikokimyasal özellikler
The Effect of Zr on LM6 Aluminum Alloy
Authors: TUNÇAY Tansel 
Published: December 2019

In this study, the effect of
Zr amount on LM6 alloys which were produced by conventional casting method and
contained different amounts of Zr (0.05% and 0.15) on the microstructure and mechanical properties of the alloys was
investigated. In addition, produced alloys were modified with 200-250 ppm
Strontium (Sr). optic microscope (OM) and scanning electron microscopy (SEM /
EDS analysis) were used for microstructure analysis. The hardness and tensile
tests of the alloys which were modified by Sr and alloyed with different
amounts of zirconium were performed. As a result of the studies that were done,
it was determined in the images of optical microscope (OM) and scanning
electron microscope (SEM) that the morphology of Al-Si-Fe phase changed
depending on the addition of Zr, and that Al-Si-Fe intermetalics having
different amounts of Zr composed. While the highest level of percent elongation
was obtained from the Al12Si alloy, the highest level of hardness and maximum
tensile strength were obtained from the LM6 alloy modified by strontium. The
highest level of yield strength was obtained from LM6 alloy which was alloyed
with 0.05 Zr. It was found that the amount of added Zr did not show a
significant difference at the maximum tensile strength level of Al12Si alloy.
Expression of the anti-Mullerian hormone, kisspeptin 1, and kisspeptin 1 receptor in polycystic ovary syndrome and controlled ovarian stimulation rat models
Authors: Risvanli Ali , Ocal Halis , Timurkaan Necati , Ipek Pınar , Seker Ibrahim , Karabulut Burak 
Published: December 2019

Polycystic ovary syndrome represents a significant cause of female infertility. The aim of this study was to investigate the expression of anti-Mullerian hormone (AMH), kisspeptin 1 (KISS-1), and kisspeptin 1 receptor (KISS1r) in rat models of polycystic ovary syndrome (PCOS) and controlled ovarian stimulation (COS). For this purpose, 28 rats were assigned into four groups. Estrus and Diestrus groups consisted of rats in estrus and diestrus phases, respectively, while COS and PCOS groups consisted of rats with induced COS and PCOS, respectively. The serum AMH, KISS-1, and estradiol levels, and ovarian KISS1r levels were analyzed by enzyme-linked immunosorbent assay. Furthermore, histopathological analysis of the ovary tissue was done and ovarian KISS-1 expression was determined by immunohistochemical assay. The results revealed that ovarian KISS1r levels were higher in the Estrus (1271.43±51.98 pg/mL) and COS (1191.43±85.67 pg/mL) groups, compared to Diestrus and PCOS groups. The highest level of AMH was found in the Estrus group (16.91±2.12 ng/mL). The results indicate that AMH had no effect on the development of COS and PCOS, while KISS-1 was found to affect the development of COS in rats.
Este "negócio" é polissemia ou homonímia?
Authors: Gritti Letícia Lemos , Dos Santos Sandra Mara Fernandes , Teixeira Lovania Roehrig , Deon Robson 
Published: December 2019

Este artigo, a partir de um ponto de vista semântico, analisa o item lexical 'negócio' usado em diferentes contextos no Português Brasileiro, desde os mais formais até os mais informais. Analisam-se as características do item, utilizando o conceito de ambiguidade. Tal fenômeno diz respeito à capacidade múltipla de significado que uma mesma palavra pode ter em determinados contextos. Mais especificamente, o estudo procura esclarecer se a ambiguidade lexical da palavra negócio é gerada por polissemia e/ou homonímia, dois tipos particulares de ambiguidade. As principais concepções teóricas são de Ilari e Geraldi (1987), Ilari (2002), Cambrussi e Poll (2015), Ferraz (2014), Pustejovsky, (1995) e Lyons (1977). Após análises, verificou-se que a palavra 'negócio' pode tanto apresentar usos em que apresenta ambiguidade por polissemia quanto ambiguidade por homonímia. Até onde se pode verificar, esse tipo de análise de 'negócio' é inédito na literatura linguística.
An evaluation of the use of ronidazole for the treatment of Tritrichomonas foetus in cats
Authors: Morgan Genever Bethan 
Published: December 2019

PICO question
In cats infected with Tritrichomonas foetus, does treatment with oral ronidazole compared to an alternative antiprotozoal treatment or placebo result in successful resolution of clinical signs and eradication of disease?
Clinical bottom line
Ronidazole use appears to be efficacious in eradicating infection with Tritrichomonas foetus and resolving diarrhoea associated with infection. A dose range of 30–50 mg/kg 12–24 hourly has been suggested, with evidence suggesting that a dose of 30 mg/kg 24 hourly for 14 days may be effective. However, some cats may require higher doses and some may not respond to treatment, and relapse may occur during a protracted period following completion of the treatment course. Neurological side effects appear to be uncommon but may occur with doses of 30 mg/kg and above.
A total of six studies are reviewed: Three randomised, controlled studies, one cohort study and two case series (one retrospective). Findings indicate efficacy of ronidazole treatment in eradicating infection and resolving diarrhoea, however many studies involved small sample sizes and limited follow-up. Therefore, evidence to support the use of ronidazole in Tritrichomonas foetus infected cats remains relatively limited.
Modification of Chaos Game with Rotation Variation on a Square
Authors: Purnomo Kosala Dwidja , Larasati Indry , Agustin Ika Hesti , Ubaidillah Firdaus 
Published: December 2019

Chaos game is a game of drawing a number of points in a geometric shape using certain rules that are repeated iteratively. Using those rules, a number of points generated and form some pattern. The original chaos game that apply to three vertices yields Sierpinski triangle pattern. Chaos game can be modified by varying a number of rules, such as compression ratio, vertices location, rotation, and many others. In previous studies, modification of chaos games rules have been made on triangles, pentagons, and -facets. Modifications also made in the rule of random or non-random, vertex choosing, and so forth. In this paper we will discuss the chaos game of quadrilateral that are rotated by using an affine transformation with a predetermined compression ratio. Affine transformation is a transformation that uses a matrix to calculate the position of a new object. The compression ratio r used here is 2. It means that the distance of the formation point is of the fulcrum, that is = 1/2. Variations of rotation on a square or a quadrilateral in chaos game are done by using several modifications to random and non-random rules with positive and negative angle variations. Finally, results of the formation points in chaos game will be analyzed whether they form a fractal object or not.
THE LARGE ANGLE QUASI-ELASTIC SCATTERING CROSS SECTIONS AND THE EFFECTIVE WEIGHT FUNCTION BASED ON THE BARRIER DISTRIBUTION FOR 32S+92,94,96,98,100Mo REACTIONS
Authors: CİNAN Zehra Merve , YILMAZ Ahmet Hakan , EROL Burcu , BAŞKAN Taylan 
Published: December 2019

We
studied quasi-elastic scattering and the effective weight function for the
barrier distribution for 32S+92,94,96,98,100Mo reactions have been calculated simultaneously
in a wide range of bombarding energies around the Coulomb barrier. The
quasi-elastic angular distribution data are analyzed using the optical model
code with Woods-Saxon potentials. It is shown that the calculations taken into
account, for these reactions can explain structures of the quasi-elastic
cross-section and the quasi-elastic barrier distribution. These results
indicate that the coupled-channels formalism can still valid even for the
various mass systems. The large-angle quasi-elastic scattering reactions were scrutinized
with the identical core-core potential recommended for designating fusion
reactions. Given the effect of a barrier distribution and nucleon transfer on
the Woods-Saxon potential, the calculated semi-elastic scattering
cross-sections of a series of reactions are in good harmony each other.
A Two-factor Model of Intra-industry Trade: A Demonstration of Robustness of Krugman’s (1980) Model
Authors: Duan Lianjie 
Published: December 2019

Abstract
Using Cobb-Douglas production function with increasing returns to scale, this paper presents an intra-industry trade model which contains two factors, capital and labor. Thus, this paper extends Krugman’s (1980) single-factor model to a two-factor model with the entry cost. Firstly, an equilibrium analysis of closed economy is carried out. After the condition of existence and uniqueness of equilibrium is obtained, the analytic solutions are given. Secondly, it provides an analysis on trade effects. The results show that, under setup of symmetry among firms, the intra-industry trade can only enable consumers to benefit from product diversification without making firms achieve economies of scale. Obviously, this conclusion is consistent with Krugman (1980), which thus indicates robustness of Krugman’s (1980) model.
Characteristics of a Campanian delta deposit controlled by alternating river floods and tides: the Loyd Sandstone, Rangely Anticline, Colorado, U.S.A.
Authors: Flaig Peter P. , Hasiotis Stephen T. , Prather Timothy J. , Burton Darrin 
Published: December 2019

ABSTRACTThe Campanian Loyd Sandstone Member of the Mancos Shale (Loyd) along the Rangely Anticline, Piceance Basin, Colorado, contains a series of multi-meter-thick, heterolithic, coarsening-upward successions (CUSs) with internal clinoforms comprising low-angle-dipping (&lt; 5°), parallel-laminated sandstone beds interbedded with bioturbated flaser-wavy-lenticular bedded sandstone and siltstone. Loyd clinoforms are delta foresets composed of prodelta and delta-front deposits, including mouthbars. Many CUSs exhibit scours filled with bioturbated sandstone, or interbedded bioturbated sandstone and siltstone or mudstone representing aggradational fill of subaqueous terminal distributary channels or the migration of mouthbars into channel scours. Mud drapes on sedimentary structures and mud rip-up clasts are extremely common. A high-abundance, high-diversity, trace-fossil assemblage includes vertical, 1–4-m-deep Ophiomorpha that may penetrate multiple bedsets of parallel-laminated sandstones and highly bioturbated finer-grained interbeds. Bioturbation increases sandstone content in finer-grained interbeds, and provides sandy conduits that increase connectivity between beds.Although parallel-laminated sandstones volumetrically dominate Loyd delta clinoforms, they likely represent relatively short-term freshwater and sediment input during river flooding that produced delta-front turbidity currents. Interbedded finer-grained beds, mud-draped sedimentary structures, and the high-abundance, high-diversity trace-fossil assemblages record longer amounts of time during reduced fluvial discharge, tidal reworking of sediments, and intense bioturbation under marine salinities. Controls on the internal characteristics of the Loyd delta deposits include: 1) a high sediment influx into a relatively shallow marine basin protected from wave action during normal regression; 2) relatively short-duration, episodic freshwater and sediment discharge from distributaries that reduced salinities, deposited sand as turbidity currents, and promoted delta-front channelization; and 3) longer-duration periods of reduced discharge with deposition of finer-grained sediment, tidal reworking, and bioturbation of sediments under higher salinities. These controls combined to produce the heterolithic, highly bioturbated, river-flood delivered, and tidally modified clinoforms of the Loyd that differ from deposits typically considered to be classic examples of fluvial-flood-dominated or extensively tidally modified deltas.
Determinants of Dietary Diversity among Pregnant Women Attending Public Health Facilities in Hossana town,South Ethiopia
Authors: Kobiro Degefa Helamo , Delil Romedan , Tamiru Desalegn , Zinab Beakal 
Published: December 2019

Abstract
Background: Dietary diversity refers to increasing the consumption of a variety of foods across and within the food groups, adequate and diversified diets during pregnancy is essential for fetus health, body maintenance and enhancement of maternal health through protection of infectious and non-communicable diseases. Hence, this study was targets to assess dietary diversity and its determinants among pregnant women of public health facilities in Hossana town, south Ethiopia Methods: Facility based cross-sectional study was applied among selected 303 pregnant women in Hossana town from June 1 to July 15, 2018. Systematic random sampling procedure was employed to recruit study participants. Data were collected using an interviewer administered pretested semi-structured questionnaire, one week dietary consumption was used to compute women dietary diversity score. Descriptive statistics and multivariable logistic regression were done to isolate predictors of dietary diversity. Result: The prevalence of low, medium and high women’s dietary diversity was 9.2, 48.2 and 42.6% respectively. Educational status (AOR=2.1; 95%CI: 4.8, 15.2), monthly income (AOR=2.1; 95% CI: 4.8, 15.2), nutritional education (AOR=2.3; 95% CI: 1.2, 4.4) and frequency of eating (AOR=12.9; 95% CI: 3.1, 52) were meaningfully associated with women dietary diversity. Conclusions: In this study women educational status, monthly income, receiving nutritional education and frequency of eating were determinants of women dietary diversity. Efforts should be strengthened towards improving women educational level, delivery of nutritional education and enhance frequency of eating among pregnant women to advance dietary diversity. Keywords: Dietary diversity, Determinants, Pregnancy
Insecticide Resistance in Anopheles stephensi in Somali Region, Eastern Ethiopia
Authors: Yared Solomon , Gebressielasie Araya , Damodaran Lambodhar , Bonnell Victoria , Lopez Karen , Janies Daniel , Carter Tamar 
Published: December 2019

Abstract
Background: The movement of malaria vectors into new areas is a growing concern in the efforts to control malaria. The recent report of Anopheles stephensi in eastern Ethiopia has raised the necessity to understand the insecticide resistance status of the vector in the region to better inform vector-based interventions. The aim of this study was to evaluate insecticide resistance in An. stephensi in eastern Ethiopia using two approaches: 1) World Health Organization (WHO) bioassay tests in An. stephensi and 2) genetic analysis of insecticide resistance genes in An. stephensi in eastern Ethiopia. Methods: Mosquito larava and pupae were collected from Kebridehar. Insecticide susceptibility of An. stephensi was tested with malathion 5%, bendiocarb 0.1%, propoxur 0.1%, deltamethrin 0.05%, permethrin 0.75%, Pirimiphos-methyl 0.25% and DDT 4%, according to WHO standard protocols. Results: All An. stephensi samples were resistant to carbamates, with mortality rates 23% and 21% for bendiocarb and propoxur, respectively. Adult An. stephensi was also resistant to pyrethroid insecticides with mortality rates 67% for deltamethrin and 53% for permethrin. Resistance to DDT and malathion was detected in An. stephensi with mortality rates of 32% as well as An. stephensi was resistance to pirimiphos-methyl with mortality rates 14%. Analysis of the voltage gate sodium channel gene (vgsc) revealed the absence of kdr L1014 mutations. Conclusion: Overall, these findings support that An. stephensi is resistant to several classes of insecticides, most notably pyrethroids. However, the absence of the kdr L1014 gene may suggest non-target site resistance mechanisms. Continued to insecticide resistance surveillance should be carried out in the region to confirm the findings on An. stephensi in Ethiopia.
What information do people with cirrhosis and their family members want during out-patient appointments? A qualitative study exploring the perspectives of patients, close family member and liver health professionals.
Authors: Low Joseph T S , Davis Sarah , Wilson Jo , Greenslade Lynda , Clancy Jennifer-Louise , Carroll Cathy , Craig Rachel , Marshall Aileen , Thorburn Douglas , Stone Patrick 
Published: December 2019

Abstract
Background: Good communication between health professionals and patients is important in healthcare, but difficult to implement in practice. This is highlighted in care for people with cirrhosis where patients have little understanding about their disease and feel stigmatized when communicating with health professionals. No study has explored the conversation exchanges between health professionals and patients with cirrhosis. This paper reports on secondary data analysis to explore the contents of patient doctor communication in hepatology out-patient clinics. Methods: Semi-structured interviews and focus groups were conducted with 12 patients, 5 close family members and 14 liver health professionals, aimed at exploring aspects of the consultation: questions asked or not asked during the consultation, the ease of answering questions, understanding of information received, and their preparation for the consultation. All interviews were audio-taped and data analysed using framework analysis. Results: Questions discussed centred on test results, symptoms and their management. Patients and family members felt comfortable with asking health professionals questions, but wanted better information about prognosis, the effects of medication on their symptoms and the likelihood of further deterioration in their liver disease. Patients had difficulty in understanding information received as it was couched in technical terms. Emphasis in consultations focused on the physical aspect of patient care leaving little time to discuss the psychological impact of their disease. Some clinicians felt patients should ask questions about their future, particularly about advance care plans. Key barriers in asking questions included: a) limited time for out-patient appointments, b) expectation that only medical issues could be discussed, c) fear about giving ‘negative’ information to patients, d) memory issues resulting from hepatic encephalopathy. Conclusions: Health professionals should use simple language when providing patients and their families with explanations about liver disease, its physical and psychological impact and prognosis. Information sheets about these topics should be made available for patients to take home. Doctors should be willing to explore supportive care issues with patients or consider referring patients to another health care professional with more time and expertise to discuss specific issues. Further work needed to explore the interactions between these groups using observational methods.
miR-188 promotes Oxaliplatin resistances through targeting RASA1 in colon cancer cells
Authors: Zhu Xijia , Luo Xishun , Song Zhike , Jiang Shiyu , Long Xiangkai , Gao Xuanyuan , Xie Xinyang , Zheng Laijian , Wang Haipeng 
Published: December 2019

Abstract
Background: The chemoresistance of colon cancer cells limits the efficacy of chemotherapy. miR-188 has been shown to be down-regulated in various types of cancer. The aim of this study was to explore the molecular mechanism of miR-188 in drug resistant cancer cells. Materials and methods: we examined the effects of miR-188 on the sensitivity of colon cancer cells to oxaliplatin (OXA) by using SW480/OXA cell line. The target of miR-188 was determined by luciferase activity assay. The cell cycle distribution were detected by flow cytometry. The expression of p21, Hoechst 33342 staining and Annexin V assays were used to detect the cell apoptosis. Results: The expression of miR-188 was significantly increased in SW480/OXA cells compared with SW480 cells. By luciferase assay we found that miR‑188 miRNA binds to RASA1 (Ras GTPase-activating protein 1, also known as p120RasGAP), and overexpression of miR‑188 inhibited RASA1 expression by binding to the 3'-untranslated region of RASA1 mRNA. In addition, suppression of miR‑188 enhanced the chemosensitivity of the oxaliplatin-resistant colon cancer cells. Furthermore, suppression of RASA1 abrogated the increasement of cell apoptosis induced by miR-188 inhibitor, while, overexpression of RASA1 induced cell apoptosis in SW480/OXA cells. Our results suggested that miR-188 played chemoresistant role in colon cancer through regulating RASA1 expression. Conclusion: The findings of our study suggest that target miR-188 is capable of enhancing the chemosensitivity of colon cancer cells by promoting RASA1.