bluuebunny/crossref_metadata_2025_split huggingface dataset:
Favorable Outcomes of LVAD as Bridge to Simultaneous Heart-Kidney Transplantation
Authors: Thohan Vinay , Murtaza Ghulam , Encarnacion Carlos O. Encarnacion , Sulemanjee Nasir , Cheema Omar , Hastings Thomas , Cho Chi , Downey Frank 
Published: October 2019

Background
Chronic kidney disease (CKD) is an established risk factor for incident cardiovascular disease and progression of heart failure disease state, and is associated with decreased survival after left ventricular assist device (LVAD) therapy or heart transplantation (HT). Combined heart-kidney transplantation (HKT) compared with isolated HT recently has been shown to have survival advantage among patients whose estimated glomerular filtration rate is less than 37 ml/min/m2. Data on LVAD to HKT are limited.
Methods
At our center, a total of 803 patients have received HT, 594 patients LVAD therapy, and 23 patients HKT from single donors; of those 23, 15 were without the use of LVAD and 8 were after support with LVAD.
Results
Kaplan-Meier survival analysis found LVAD-supported patients with CKD stages 4 or 5 had statistically worse 24-month survival after HT as compared with those with CKD stage 1, 2, and 3 (58% versus 88%, p=0.01). Patients who received combined HKT after LVAD had comparable 24-month survival with those who received HKT without LVAD (87% and 85%, p=NS); both groups had numerically better survival compared with those who had CKD (stage 4-5) with isolated HT (58%).

Conclusions
Patients supported with LVAD who demonstrate advanced CKD (stage 4-5) have worse 24-month post-HT survival compared with those with less advanced CKD (stage 1-3). Combined HKT after LVAD support is feasible and confers comparable 24-month survival compared with HKT without prior LVAD therapy. Our study supports combined HKT for select LVAD patients with advanced CKD (stage 4-5).
VA-ECMO in Cardiogenic Shock in Adults: Indications and Outcomes
Authors: Guglin Maya , Burchett Andrew 
Published: October 2019

Background
Use of veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) has become increasingly common as a means of providing hemodynamic support for patients in cardiogenic shock. Data regarding the efficacy of VA-ECMO are provided almost exclusively by single-center, retrospective analyses. These retrospective analyses vary significantly with regards to documentation of the underlying pathophysiologic process resulting in cardiogenic shock.
Methods
Relevant published studies were identified by using a comprehensive search of English-language MEDLINE from 1966 to November 2015. Relevant references found cited in these studies were also analyzed. These studies were analyzed with regard to the indications the authors used for initiation of ECMO, as well as the outcomes for each indication in each individual study.
Results
Analysis of multiple relevant studies regarding the indications for ECMO support demonstrated that there is a great deal of variability with regard to the use of different indications for initiation of ECMO support.
Conclusions
Data regarding the efficacy of VA-ECMO is derived largely from single-center, retrospective analyses. In order to gain a better understanding of the efficacy of VA-ECMO in different patient populations, a more standardized format of documenting the indication for VA-ECMO should be used in centers that provide VA-ECMO. In general, all patients supported with VA-ECMO are in cardiogenic shock. In our experience, the underlying processes leading to cardiogenic shock can be classified as: cardiac arrest, acute decompensated congestive heart failure, acute on chronic congestive heart failure, myocardial infarction, acute pulmonary embolism, right ventricular failure not secondary to acute pulmonary embolism, and post-cardiotomy syndrome.
Safety and Efficacy of Routine Bridging Anticoagulation for Subtherapeutic Anticoagulation in Outpatients with a Left Ventricular Assist Device
Authors: Shisler David C. , Vaidya Gaurang N. , Muncy Lori , Vijayakrishnan Rajakrishnan , Slaughter Mark S. , Birks Emma J. , Abramov Dmitry 
Published: October 2019

Background
Anticoagulation with vitamin K antagonists is vital to prevent pump thrombosis in patients with left ventricular assist devices (LVADs). However, the safety and efficacy of bridging anticoagulation for the routine management of subtherapeutic international normalized ratio (INR) in stable outpatients remains poorly characterized.
Methods
In this retrospective study, a total of 60 LVAD outpatients had 110 episodes of subtherapeutic INR noted on routine testing. 34 of these episodes were managed with parenteral bridging anticoagulation and 76 were managed with only an adjusted dose of warfarin. The rates of bleeding and thromboembolic adverse events following these episodes of subtherapeutic INR were measured to evaluate the safety and efficacy of bridging anticoagulation in this population.
Results
Ischemic cerebrovascular events occurred following 2 bridged episodes compared to 4 non-bridged episodes (6% vs. 5%, p=0.895). Hemolysis occurred following 1 bridged episode compared to 3 non-bridged episodes (3% vs. 4%, p=0.794). Bleeding events occurred after 4 bridged episodes compared to 13 non-bridged episodes (12% vs. 17%, p=0.474). In a subgroup of patients with either a CHA2DS2-VASc score > 3 or a history of atrial fibrillation, thromboembolic events occurred only in those who did not receive bridging anticoagulation although this result was not statistically significant.
Conclusions
There was no benefit associated with the routine use of bridging anticoagulation in a general population of stable LVAD outpatients with subtherapeutic INR. A trend towards benefit was seen in a subset of patients with a CHA2DS2-VASc score of > 3 or a history of atrial fibrillation.
De-airing method of an axial flow left ventricular assist device influences post-operative lactate dehydrogenase levels: a possible explanation for some episodes of pump thrombosis
Authors: Tanaka Daizo , Rizvi Syed-Saif Abbas , Boyle Andrew , Entwistle John WC 
Published: October 2019

Background
Pump thrombosis (PT) is a relatively uncommon but serious complication of a left ventricular assist device (LVAD). We believe that de-airing of the HeartMate II (HMII) with the pump turned on and a clamp across the outflow graft may lead to early thrombus formation due to heat generation on the bearings.
Methods
Patients who underwent HMII implantation from November 2012 to February 2016 were retrospectively reviewed. Patients were separated into two groups depending on the timing of removing the clamp from the outflow graft. Patients in Group 1 underwent de-airing by turning on the pump with the vascular clamp on the outflow graft and patients in Group 2 were completely de-aired with the pump off and the pump was only activated after removing the clamp.
Results
There were 45 patients in Group 1 (“clamp on”) and 33 patients in Group 2 (“clamp off”). Five patients had PT in Group 1 but none in Group 2 (p=0.07). Average LDH levels in the early postoperative period were similar (404±168 IU/L vs 425±267 IU/L; p=0.71). However, average LDH levels in the late postoperative period were significantly higher in Group 1 (388±214 IU/L vs 313±73 IU/L; p=0.045).
Conclusion
De-airing a running HMII with the outflow graft clamped increases LDH levels, suggesting that the bearings may act as a nidus for early thrombus formation caused by the lack of heat dissipation. Delaying pump activation until removal of the clamp on the outflow graft may affect the incidence of PT after HMII implantation. This may have potential importance in any VAD where there are mechanical bearings or other areas susceptible to heat generation.
Restoration Of Left Ventricular Function Following LVAD Implantation – Remission Or Recovery? A Case series
Authors: Joshi Shiksha , Barlow Mariah , Guglin Maya 
Published: October 2019

Background
A wide range of left ventricular (LV) recovery rates on left ventricular assist device (LVAD) support have been reported. In this case series, we summarize our experience with LVAD explantation for presumed LV recovery.
Case series
Out of 240 patients who received an LVAD implant in our program since its inception, we explanted/inactivated the pump for presumed LV recovery in only three patients. All three of these patients had relapse of cardiomyopathy within 6 months of explantation.
Conclusion
Our experience does not support the existence of LV recovery following LVAD implantation as a common phenomenon. Improvement in LV function on LVAD is sustainable only with mechanical circulatory support and once the offloading support provided by the device is removed recurrent failure quickly ensue. Likely the term “remission” reflects the status more accurately than the term “recovery”.
Managing Intracranial Hemorrhage in Patients with a Durable Continuous Flow Left Ventricular Assist Device
Authors: Jack Godly , Barker Phil , Searcy Ryan , Katz Jason N. 
Published: October 2019

Background
While intracranial hemorrhage (ICH) is a known complication of left ventricular assist device (LVAD) support, and is associated with high morbidity and mortality, optimal care pathways have neither been elucidated nor reported. We describe management of LVAD patients following ICH, with a focus on anticoagulation, operative interventions, care team designation, complications, and outcomes.
Methods
We retrospectively reviewed all durable continuous-flow LVAD implantations at our academic medical center from January 2007 to July 2018. Patients who experienced ICH after LVAD were identified. We defined baseline and ICH characteristics, medical and surgical interventions, care teams, and outcomes including death, device thrombosis, ischemic stroke, and hemorrhage expansion.
Results
A total of 321 patients underwent LVAD implantation during the study period, and 27 (8%) developed ICH (17 intraparenchymal, 7 subdural, 2 subarachnoid, 1 intraventricular) while on support. Twenty-five were anticoagulated at onset of bleed. Of those, 13 were managed with immediate cessation of anticoagulation and administration of reversal products (Group A). Group A had a median of 6 days off anticoagulation and 60 days of follow up with 1 patient (8%) developing device thrombosis at day 8, 1 (8%) developing subsequent ischemic stroke at day 14, and 4 (31%) with ICH expansion. Seven patients had anticoagulation stopped at onset of bleed without administration of reversal products (Group B). With a median of 2 days off anticoagulation and 2 days of follow up, no patients in Group B developed ischemic stroke or device thrombosis while 1 (14%) had ICH expansion. Five patients had anticoagulation continued at onset of bleed (Group C) with a median follow up of 330 days. One (20%) developed device thrombosis at day 5 while 2 (40%) developed ICH expansion. Four patients with subdural hemorrhage underwent Burr hole drainage with all 4 surviving to discharge. Two patients with intraparenchymal hemorrhage underwent open craniotomy with neither surviving to discharge. An interdisciplinary discussion occurred in all cases. Following ICH, only one-third of patients in the study survived to 6 months.
Conclusion
LVAD patients who experience an ICH have variable outcomes. Their care is multidisciplinary and can involve operative intervention. The discontinuation and reversal of anticoagulation is generally well-tolerated, with a low risk for early device thrombosis. Like for many hemorrhagic complications of LVADs, ICH often persists or worsens. Additional investigation is needed to elucidate the most optimal management strategies.
𝜔+-Type Index of GL+(2)-Paths
Authors: Liu Sai , Wang Wei 
Published: October 2019

Abstract
In this paper, we establish an

ω
+

{\omega^{+}}

-type index theory for paths in the general linear group

GL
+

⁢

(
2
)

{\mathrm{GL}^{+}(2)}

. This is done by the complete homotopy classification for such paths. We also compare this index theory with the ω index theory for paths in the symplectic group

Sp
⁢

(
2
)

{\mathrm{Sp}(2)}

and obtain a generalization of Bott formula for iterated paths in

GL
+

⁢

(
2
)

{\mathrm{GL}^{+}(2)}

. As applications, the minimal periodic solution problem and the linear stability of general differential systems are studied.
Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons
Authors: Hallinan Grace I. , Vargas-Caballero Mariana , West Jonathan , Deinhardt Katrin 
Published: October 2019

Neurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a pathological hallmark of several neurodegenerations, including Alzheimer's disease. Tau pathology spreads between neurons and propagates misfolding in a prion-like manner throughout connected neuronal circuits. Tauopathy is accompanied by significant neuronal death, but the relationships between initial tau misfolding, propagation across connected neurons and cytotoxicity remain unclear. In particular the immediate functional consequence of tau misfolding for the individual neuron is not well understood. Here, using microfluidic devices to recreate discretely organized neuronal connections, we show that the spread and propagation of misfolded tau between individual murine neurons is rapid and efficient; it occurs within days. The neurons containing and propagating tau pathology display selective axonal transport deficits but remain viable and electrically competent. Therefore, we demonstrate that seed-competent misfolded tau species do not acutely cause cell death, but instead initiate discrete cellular dysfunctions.SIGNIFICANCE STATEMENTPublic awareness of progressive neurodegenerations such as dementias associated with aging or repetitive head trauma is rising. Protein misfolding underlies many neurodegenerative diseases including tauopathies, where the misfolded tau protein propagates pathology through connected brain circuits in a prion-like manner. Clinically, these diseases progress over the course of years. Here we show that the underlying protein misfolding propagates rapidly between individual neurons. Presence of misfolded tau is not directly cytotoxic to the neuron; the cells remain viable with limited deficits. This suggests that neurons with tau pathology could be rescued with a therapeutic disease modifier and highlights an under-appreciated time window for such therapeutic intervention.
Biológiai terápia szisztémás alkalmazása a szemészetben
Authors: Benyó Fruzsina , Farkas Alexandra , Horváth Hajnalka , Nagy Zoltán Zsolt , Szepessy Zsuzsanna 
Published: October 2019

Abstract: We present herewith cases of non-infectious uveitis with biological treatment where the ocular complaints were the initial symptoms indicating a multi-organ autoimmune disease. The first case was a patient with panuveitis and Vogt–Koyanagi–Harada disease, the second case was also a panuveitic patient with sarcoidosis and the third case was a patient with intermediate uveitis and inflammatory bowel disease. In all cases, emerging new, biological therapy (adalimumab) was necessary to achieve permanent inactive period of uveitis and the autoimmune disease. Introducing systemic biological treatment (adalimumab) in ophthalmology is crucial in the therapy of immune-mediated, non-infectious uveitis in order to preserve visual acuity. Orv Hetil. 2019; 160(44): 1744–1750.
EXTRACTION OF LIGNIN FROM SUGARCANE BAGASSE BY DEEP EUTECTIC SOLVENTS (DESs)
Authors: Thao Nguyen Bui Thi , Tru Nguyen Nhi , Minh Hoang Thai Ngoc , Duong Nguyen Hoang , Cuong Tran Manh 
Published: October 2019

Lignin plays a crucial role as a structural material of plant cell walls and is also known as a significant renewable resource that has the potential to be a raw material for producing high value chemicals. The article aimed to research on the extraction of lignin from sugarcane bagasse by environmental method using deep eutectic solvents (DESs) containing choline chloride and formic acid. In the process, lignins dissolved in DESs were isolated from the solution by dilution with water and ethanol. The obtained lignin samples were characterized with UV - Vis (Ultraviolet – visible spectroscopy), FT-IR (Fourier-transform infrared spectroscopy), GPC (Gel permeation chromatography), and 1H-NMR (Proton nuclear magnetic resonance). The initial results showed that the extracted lignin obtained adequately distinct functional groups and the weight average molecular mass of the lignin was about 28265 g/mol.
EFFECT OF CERIUM OXIDE ON PROPERTIES OF LOW-PROTEIN VULCANIZED NATURAL RUBBER
Authors: Nguyen Thanh Thi Le , Cao Viet Xuan , Nguyen Linh Vu Viet 
Published: October 2019

Natural rubber (NR) latex is considered as a “green material” because of its natural origin and a sustainable choice as well as it minimizes environmental impacts so that it has become an integral part of our daily lives. However, natural latex may contain allergenic proteins that need to be removed and this process affects the properties of vulcanized materials. In this study, an attempt has been made to incorporate cerium oxide (CeO2) into low-protein NR latex and effect of CeO2 content on the mechanical properties of the CeO2/ vulcanized rubber composite films such as tensile modulus 100% (M100), tensile modulus 300% (M300), tensile strength, tear strength was investigated. The results show that the properties of low-protein NR films were stable after 48 hrs of incubation. In particular, the mechanical properties were remarkably improved while increasing CeO2 content from 2 to 4 phr. In addition, aging resistance (AR) ability by evidence of thermal degradation and Q-sun environment test in the presence of CeO2 (4 phr) is excellent whilst AR coefficient is closest to zero. This research has provided an initial prospect of the use of rare earth oxide to produce commercially valuable products from the natural rubber resources in Vietnam.
Retrospective Review of Oral Probiotic Therapy
Authors: Cannon Mark L , Vorachek Ashlee , Le Catherine , White Kevin 
Published: October 2019

Purpose: There have been many in vitro studies reporting on the efficacy of probiotic bacteria in inhibiting pathogens, and there have been published studies reporting on the inhibitor effects of probiotic bacteria on the salivary levels of bacterial pathogens. However, there have not been but a few studies on the clinical benefits of oral probiotic therapy. Study design: Dental records of 60 patients that were enrolled in an Institutional Review Board approved study were reviewed as to current caries activity status with measurement of the Decayed Missing Filled Teeth index and by Caries Management By Risk Assessment (CAMBRA) determination. The current oral health status was compared to the prior-to-study enrollment status and then analyzed in respect to published national norms.The data (without any identifiers) had a statistical analysis by a blinded biostatistician. The data was subjected to statistical analysis (Statsgraphic) before and after the probiotic therapy. Results: Of the 53 subjects available for follow up, only 4 had remained caries active with a grand total of 27 carious lesions being detected and subsequently restored in this group. Of the original total of 60 patients with 292 initial carious lesions, after probiotic therapy and dental restoration, 78 total restorations were placed in the subject group over the following three years. Approximately half of these restorations were required in teeth that had initially presented with smaller lesions and had been placed in a “watch” category. Two of the patients that developed further carious lesions had been randomly assigned to the probiotic PerioBalance, while the other two caries active patients were assigned EvoraKids probiotic.Of the original group of caries active patients, 24 did not present with any further carious involvement. Another 25 could be categorized as caries static, as the restorations required were substantially less than before probiotic therapy had been begun. The F-ratio, which in this case equals 51.3313, is a ratio of the between-group estimate to the within-group estimate. Since the P-value of the F-test is less than 0.05, there is a statistically significant difference between the means of the 4 variables at the 95.0% confidence level. Conclusion: The tested probiotic supplements had a statistically significant effect on the caries experience of the enrolled subjects.
Я. П. Полонский как предшественник русского символизма: поэтика лирического цикла ("Сны" Полонского и "Жизнь моего приятеля" Блока)
Authors: Федосеева Татьяна 
Published: October 2019

Творческое наследие Я. П. Полонского мировоззренчески и чертами поэтики предшествовало русскому модернизму в целом и символизму в частности. В. С. Соловьев обосновывал эту общность романтической направленностью личности поэта и ее устремленностью к идеалу. Полонский предварил русский символизм тем, что, утверждал идеальное начало в формах действительной жизни. Органичность его творчества программе младших символистов состояла в абсолютном доверии художественному образу как «символу религиозной реальности» (А. А. Асоян). В лирических циклах Полонского и Блока показана драматическая разобщенность сообщества людей, утративших духовные смыслы бытия. Следствием этой утраты становится страдание и смерть (мотив Возмездия). Наиболее напряженным моментом в развитии лирического сюжета у Полонского является одиночество героя в абсолютной темноте и пустоте безжизненного мистериального пространства. У Блока одиночество героя показано в антитезе неподвижного «отменного порядка» обыденности стихийному движению порожденных сном воспоминаний, предчувствий, мыслей. Сны Полонского завершаются мотивом Преображения через обретение тайной книги. Цикл Блока – утверждением посмертного страдания богоотступника. Сюжетно-мотивный анализ двух циклов позволяет установить их родственность на уровне символического функционирования мотивного комплекса апокалиптического сюжета.
Поэзия Галины Кузнецовой в контексте творчества Ивана Бунина (тематический аспект)
Authors: Witczak Patryk 
Published: October 2019

Галина Кузнецова – русская писательница, поэтесса, мемуаристка. Ее самым большим литературным достижением является Грасский дневник, в котором описывает жизнь с Иваном Буниным, который оказал сильное влияние на формирование художественной личности эмигрантки. В статье анализируются мотивы поэзии Кузнецовой (смерть, родина, любовь) в контексте лирики Бунина.
Монтаж как сюжетный прием в драматургии Вадима Леванова
Authors: Журчева Татьяна 
Published: October 2019

Статья посвящена проблеме монтажа как сюжетообразующего приема, активно используемого в современной драматургии. Возможности монтажа рассматриваются на примере последних пьес Вадима Леванова. Он – один из наиболее известных представителей новейшей российской драмы рубежа XX–XXI веков, и в творчестве Леванова отразилось все многообразие идейных и художественных исканий современной драматургии. Драматургический диптих Святая блаженная Ксения Петербургская в житии и Кровавыя барыни Дарьи Салтыковой, московской столбовой дворянки правдоподобное и елико возможно достоверное жизнеописание, а также Пьеса про коров несомненно были программными произведениями Леванова, в которых отразились его философские искания. В статье показано, как использование приема монтажа позволило драматургу выразить свое отношение к извечной оппозиции добра и зла.
Виктор Шкловский в диалоге с Шекспиром
Authors: Мних Людмила 
Published: October 2019

В статье рассмотрен шекспировский дискурс в работах видного представителя русского формализма Виктора Шкловского. Автор анализирует литературоведческие работы Шкловского, в которых интерпретируются тексты Шекспира. В ранних работах 1920–30-х годов В. Шкловский обращался к Шекспиру для обоснования новой терминологии русских формалистов, а более поздние работы ученого уже непосредственно посвящены изучению произведений Шекспира.