bluuebunny/crossref_metadata_2025_split huggingface dataset:
CORRELATION BETWEEN STANDARDIZED UPTAKE VALUE AND HISTOPATHOLOGY OF OESOPHAGEAL CARCINOMA: A SINGLE CENTER ANALYSIS
Authors: Hassan Aamna , Majeed Yasir , Bashir Humayun , Nawaz Khalid 
Published: December 2019

Aim: This study aims to evaluate the correlation between oesophageal cancer histopathology and the standardised uptake value (SUV) of the primary lesion on positron emission tomography/computed tomography (PET/CT) scan.Methods: We reviewed clinical data of consecutive newly diagnosed oesophageal cancer patients who underwent positron emission tomography with 2-deoxy-2-[ uorine-18] uoro-D glucose integrated with CT (18F-FDG PET/CT) between September 2009 and July 2014. Results: A total of 289 baseline scans were performed in this 55-month period. Of these, 171 (59%) were male. The mean age was 52.6 years (standard deviation ± 12.4 years). On histological review, 214 were squamous cell carcinomas (SCCa) and 75 were adenocarcinomas. Of the SCCa, 15.9% were poorly differentiated, 70.6% were moderately differentiated and 13.5% were well differentiated. Of the adenocarcinomas, 20% were poorly differentiated, 45% were moderately differentiated, 28% were well differentiated and signet ring cell was 7%. Mean maximum SUV (SUVmax) for SCCa was 12.6 ± 5.14 and 10.5 ± 6.2 for adenocarcinomas. In bivariate analysis, being a female was associated with a higher SUV in the primary lesion by 1.66 units (P = 0.011) compared to males. Adenocarcinomas were associated with a lower SUV by 2.14 units (P = 0.004) compared to SCCa. In bivariate analysis, no signi cant correlation was found between the T-stage of the tumour and the SUVmax of the primary tumour (P = 0.339). Multivariate analyses showed no association of the SUV of the primary oesophageal tumour with the degree of differentiation of either SCCa or adenocarcinoma. There was no correlation between the SUVmax of the primary lesion and the presence or activity level of a metastatic focus, whether visceral or nodal. Conclusion: At our centre, three-fourths of patients with oesophageal carcinoma had squamous cell carcinoma on histology. Adenocarcinoma is associated with a lower SUV compared to SCCa. There is no association between the SUVmax and degree of differentiation of the primary oesophageal cancer. Key words: Fluorodeoxyglucose, oesophageal adenocarcinoma, oesophageal squamous cell carcinoma, positron emission tomography/computed tomography, standardised uptake value
PROGNOSIS OF BREAST CANCER IN VERY YOUNG AGE (LESS THAN 30 YEARS)
Authors: Bano Razia , Salim Mariam , Khan Amina Iqbal , Zaidi Akif 
Published: December 2019

Purpose: Breast cancer diagnosed at a younger age has aggressive biology being triple negative and high grade and is associated with poor prognosis.Materials and Methods: Retrospectively data of 121 patients age 30 years or younger registered during the year 2008 were reviewed. Data were extracted from the cancer registry department of the institute. Demographics studied were the age at diagnosis, gender, pregnancy or lactation association, family history of breast cancer, histopathological diagnosis, and stage of the disease, receptors, type of treatment, response, local recurrence, distant relapse, and survival. Results: A total of 121 patients with age 30 years or less were included. An only a single patient was male. The age range was from 20 to 30 years; bilateral involvement was seen in a single patient. Almost half 50.4% (n = 61) patients had locally advanced disease at presentation. Pregnancy/lactation-associated breast cancer was seen in 29.8% (n = 36). The most common stage was Stage III (52.1%) and Stage II (33.9%). Invasive ductal carcinoma was the most common histology 94.2% (n = 114) of patients; triple negative was the most common molecular subtype present in 46.3% (n = 56). Chemotherapy was received by 92.6% (n = 112), 88.4% (n = 107) patients received radiation therapy. Modi ed radical mastectomy was performed in 57% (n = 69), breast conservation surgery in 35.5% (n = 43), follow- up period was 5 years, local recurrence was observed in 12.4% (n = 15) and cancer related deaths were 42.1% (n = 51). Conclusions: Breast cancer in very young has very aggressive tumour biology, needs aggressive treatment with surgery, chemotherapy, radiation therapy and hormonal therapy. Key words: Breast cancer, pregnancy-associated aggressive tumour biology, triplenegative, young
CLINICOPATHOLOGICAL CHARACTERISTICS OF PATIENTS WITH SYNCHRONOUS PRIMARY OVARIAN AND ENDOMETRIAL CANCERS
Authors: Chaudary Samreen , Sadaf Tabina , Butt Sumera , Syed Aamir Ali , Siddiqui Neelam 
Published: December 2019

Purpose: Synchronous primary endometrial and ovarian cancers are infrequent. The objective of this study is to evaluate clinicopathological characteristics of synchronous endometrial and ovarian cancers treated in our institution.Materials and Methods: The clinicopathological characteristics of 12 patients with synchronous ovarian and endometrial cancers treated at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, from July 2005 to July 2015, were reviewed retrospectively in depth from hospital database. The WHO committee classification was used for the histologic determination and staged based on International Federation of Gynaecology and Obstetrics (FIGO) staging. Results: The median age at the time of diagnosis was 50 years (range 23–66 years). The incidence of synchronous primary endometrial and ovarian cancers was 2.01% in patients with endometrial cancer. A total of seven patients were menopausal (58%) and eight patients were nulliparous (66%); the median body mass index (BMI) was 29 kg/m2 (range, 20–38). Abnormal uterine bleeding was the most common presenting symptom. According to FIGO stage, 10 cases of endometrial were Stage I/II (84%) and two cases were Stage III (16%). Of the ovarian cancers, nine cases were Stage I/II (83.3%) and two cases were Stage III (16.7%). Endometrial cancer was the main pathological type in uterine carcinoma (86%) followed by serous carcinoma (14%), and similarly, for ovarian cancer, endometrial was the most common pathology (67%) followed by serous/clear cell (16%) and mucinous (16.7%). Most endometrial and ovarian primaries in our series were Grade I and II tumours, 83% and 66%, respectively. 8 patients (66%) had similar histology in both primaries. All patients underwent surgical intervention. Only one patient did not receive any post-operative adjuvant therapy. 10 patients received platinum-based adjuvant chemotherapy and six patients received adjuvant radiotherapy. Conclusion: Synchronous primary endometrial and ovarian cancers are infrequent and distinct set of patients. Abnormal per vaginal bleed was the most common symptom which helped in early detection. Majority of the patients belong to concordant endometrial histology, low grade, had younger age and high BMI. Treatment should be tailored to the stage, histology and grade of the individual tumours. Key words: Endometrial cancer, ovarian cancer, synchronous tumours
PICTORIAL REVIEW OF EXTRAOSSEOUS EWING’S TUMOUR: A SINGLE CENTER EXPERIENCE
Authors: Fayyaz Muhammad Bilal , Niazi Imran Khalid , Iqbal Amjad 
Published: December 2019

Purpose: Ewing’s family tumour is an extremely rare tumour, with annual incidence rates amongst Caucasian children <21 years being in the range of 2–3 cases per million in the U.S. There are mainly three subtypes including Ewing’s sarcoma (ES) of bone, extraosseous (EO) Ewing’s tumour and Peripheral primitive neuroectodermal tumour. Although extremely rare, this study represents a review of various types of cases and the significance of imaging including its baseline and post-treatment response radiological characteristics. There are a very few cases of EO ES in the current literature with variable spectrum of tumour site and their imaging characteristics.Materials and Methods: Electronic records were retrospectively reviewed from 1 May 2011 to 1 May 2016 with patients who were diagnosed as histologically proven ES. A number of patients, gender and base line computed tomography (CT)/magnetic resonance imaging findings for staging were reviewed.Results: A total of 568 patients with diagnosed ES were analysed, of which 15 patients had EO type of ES. Of these only 8 patients had baseline imaging available which included tumours arising from the occipital region, orbit, anterior mediastinum, anterior abdominal wall, mesentery, kidney, prostate gland and presacral region.Conclusion: EO ES is a rare entity and can involve a wide array of soft tissue organs. A cross-sectional imaging with CT and MR has a key role in pre- and post-treatment assessment.Key words: Computed tomography, Ewing’s sarcoma, extraosseous Ewing’s, magnetic resonance imaging, peripheral primitive neuroectodermal tumour
INDOLEAMINE 2,3 DIOXYGENASE AS AN IMMUNOTHERAPEUTIC TARGET BRINGS A NEW HOPE FOR CANCER PATIENTS
Authors: Asghar Kashif , Loya Asif 
Published: December 2019

Therapeutic manipulation of immune system in cancer has been an extensive area of research in the field of oncoimmunology. Immunotherapy helps the immune system to combat against cancer. Tumour cells take an edge of immunosuppressive mechanisms and inhibit antitumour immune responses. Indoleamine 2,3 dioxygenase (IDO) is an immunosuppressive enzyme which is involved in tumour immune escape mechanism in various cancers. IDO can degrade the tryptophan into kynurenines and has an ability to enhance the immune tolerance through mammalian target of rapamycin pathway general control nonderepressible 2 (GCN2) pathway and induction of regulatory T (T-regs) cells. IDO-induced T-regs suppress the local immune responses in the tumour microenvironment and promote metastasis. IDO overexpression in various cancers is associated with poor prognosis. Several preclinical and clinical trials have been proceeding and recommend that IDO inhibitor may be an influential tool against a wide range of cancers. IDO inhibitors as adjuvant therapeutic agents may also have clinical implications. Thus, IDO has the potential to be used as an immunotherapeutic target. This review discusses the promising role of IDO in cancer and its implication in immunotherapy.Key words: Breast cancer, colorectal cancer, haematological malignancies, immunotherapy, indoleamine 2,3-dioxygenase, pancreatic cancer, prostate cancer
HYBRID SCINTIGRAPHY OF RARE SPLENIC HAMARTOMA
Authors: Razi Mairah , Bashir Humayun , Faruqui Zia Salman 
Published: December 2019

Splenic hamartoma, also known as splenoma, splenic adenoma or nodular hyperplasia, is a rare benign splenic tumor. It is composed of disordered vascular channels with abnormal mixture of red or white splenic pulp. Mostly it is asymptomatic and encountered incidentally at imaging, surgery or autopsy. Radiologically hamartomas are almost identical to hemangioma. In such circumstances radiolabelled blood pool imaging and radiocolloid scintigraphy helps to differentiate the two entities. We present a case of asymptomatic splenic lesion on hybrid radionuclide imaging with SPECT-CT, findings suggestive of hamartoma. Key Words: Splenic hamartoma, SPECT-CT, Radiocolloid scintigraphy
KOMPARASI KELENGKAPAN IMUNISASI DASAR PADA BAYI DENGAN IBU YANG BEKERJA DAN TIDAK BEKERJA
Authors: Purnama Sari Etika 
Published: December 2019

ABSTRAKKelengkapan pemberian imunisasi dasar perlu mendapatkan perhatian khusus dari orang tua terutama para ibu yang bekerja ataupun yang tidak bekerja. Peran ibu sangat mempengaruhi tercapainya kelengkapan imunisasi dasar. Tujuan dari penelitian ini adalah menjelaskan perbedaan kelengkapan imunisasi dasar pada bayi antara ibu yang bekerja dan tidak bekerja. Desain penelitian adalah komparasi dengan pendekatan cross sectional. Variabel yang diteliti adalah kelengkapan imunisasi dasar. Sampel yang digunakan adalah ibu yang memiliki bayi usia 9-12 bulan sebanyak 30 orang. Pengambilan data digunakan dengan observasi status imunisasi pada KMS. Berdasarkan hasil uji Mann Whitney U Test didapatkan nilai p=0.133 (α<0.05) yang berarti tidak ada perbedaan kelengkapan imunisasi dasar pada bayi dengan ibu yang tidak bekerja dan tidak bekerja. Tidak adanya perbedaan dikarenakan pada kelompok ibu yang bekerja dan yang tidak bekerja sebagian berpendidikan tinggi. Bagi para ibu harus tetap memiliki tanggung jawab untuk kelengkapan imunisasi bayinya.Kata kunci: imunisasi, ibu, bekerjaABSTRACTCompleteness of basic immunization needs special attention from parents, especially working mothers or were not working. The role of the mother greatly affect the achievement of complete basic immunization. The aim of this study is to explain the differences completeness of basic immunization in infants between mothers working and not working. The study design was comparative with cross-sectional approach. The variables were the completeness of basic immunization. The samples used were mothers with babies aged 9-12 months as many as 30 people. Data was collected by the observation immunization status at KMS. Based on the test results of the Mann Whitney U Test p=0.133 (α<0.05) which means there is no difference in the completeness of basic immunization in infants with mothers who are not working and not working. No difference because the group of the mothers who work and who do not work most highly educated. For the mother must continue to have responsibility for the completeness of infant immunization.Keywords: immunization, mother, work
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Untangling the Origin of Molecular Hydrogen in the Lunar Exosphere
Authors: Crandall Parker B. , Gillis-Davis Jeffrey J. , Kaiser Ralf I. 
Published: December 2019

Abstract
In situ experiments from the Apollo missions confirmed the presence of a tenuous exosphere on the Moon comprised of atoms and light molecular species. Of the most prominent volatiles found in the exosphere, molecular hydrogen (H2) has drawn considerable attention because the confirmed detection of surface water has led many scientists to believe that proton bombardment of silicate minerals from the solar wind is the mechanism by which this water forms. As molecular hydrogen formation is a competing mechanism to bound OH/H2O in the regolith, experimental studies are needed to determine the efficiency of molecular hydrogen formation from the solar wind. Here we show that, under simulated lunar conditions, the formation, storage, and release of molecular deuterium—as a proxy of molecular hydrogen—from deuteron implanted olivine is facile. Secondary ion mass spectrometry results reveal that diffusion processes also enrich grains with deuterium at depths beyond the maximum penetration depth of the incident ions close to 100 nm. In addition, the maximum yield of molecular deuterium escaping the amorphous rims under simulated lunar conditions strongly supports previous studies, which claim that the solar wind represents the dominant source of exospheric molecular hydrogen.
Explorer et gérer les espaces de discussion sur le travail
Authors: Collard Damien 
Published: December 2019

Dans cet article, nous nous intéressons aux espaces de discussion consacrés au travail, à leurs caractéristiques, mais aussi à ce qui se joue et à ce qui se dit dans ces lieux. Une recherche-action menée dans un service de gériatrie nous a conduits à explorer les dynamiques communicationnelles qui s’instaurent dans ces espaces et à réfléchir à leur ingénierie, ce qui induit plusieurs questions. Tout d’abord, comment les définir et les repérer quand on sait qu’ils sont potentiellement très nombreux ? Ensuite, faut-il les structurer, les équiper et les connecter entre eux ? Enfin, faut-il proposer la mise en place de nouveaux espaces de discussion, et dans quel but ?
Des collectifs peuvent-ils émerger chez des travailleurs indépendants ?
Authors: Ottmann Jean-Yves , Felio Cindy , Boudes Mélissa , Mokaddem Sarah 
Published: December 2019

Etant privés de collectifs de travail, les travailleurs indépendants sont dans une situation traditionnellement associée à des enjeux de solitude. Or, les collectifs de travail constituent dans le cadre du salariat classique une ressource pour les travailleurs. Par la comparaison de trois enquêtes, cet article montre comment des travailleurs indépendants se saisissent de services et structures disponibles (coopérative d’activité et d’emploi, entreprise de portage salarial, espaces de coworking) pour faire émerger des formes de collectifs qui leur apportent des ressources proches de celles dont disposent les travailleurs salariés « classiques ». Ces collectifs émergents se distinguent toutefois par leur relative fragilité.
La lettre d’amour chez Freud : Une voie d’élaboration pulsionnelle
Authors: Kamieniak Jean-Pierre 
Published: December 2019

La lettre d’amour peut-elle constituer une voie d’élaboration pulsionnelle ? Une approche de la nature et des conditions propres à l’abondante correspondance du jeune Freud avec sa fiancée met en évidence que ces échanges épistolaires nourris ont constitué pour le futur savant une voie propice à la satisfaction libidinale, en même temps qu’ils lui permettaient d’opérer ce travail psychique de métabolisation des motions pulsionnelles générées par l’état amoureux.
De la lettre au texto, du texte à la Lettre
Authors: Minari Marion 
Published: December 2019

De la lettre écrite sur papier au texto tapé sur écran, le support de l’écrit et des échanges s’est transformé. Ce nouveau support a engendré différents phénomènes : l’invention d’une néographie, une écriture inscrivant l’oral ; une temporalité asynchrone, donnant l’illusion de l’instantanéité ; et peut-être un rapport à l’autre différent. En effet, le texto modifie la façon d’écrire à l’autre, le texte est plus court, moins déployé, numérique, il est truffé de smileys et d’images. Ce nouveau support transforme-t-il pour autant ces liens ? A-t-on glissé du développement d’une pensée dans la lettre écrite au témoignage d’une présence dans le texto qui déclenche la vibration du téléphone dans la poche, quand l’écran s’illumine ?
Sexpistolarité freudienne
Authors: Leleux Fabienne-Charlotte 
Published: December 2019

À la question « En quoi et comment la lettre « fait-elle » l’amour ? », les lettres de Freud à Fliess apportent un éclairage qui fait défaut aux travaux littéraires, concentrés sur l’énoncé des correspondances. L’érotisation de l’énonciation, et la sublimation qui va de pair, tient à la dimension de parole propre aux lettres et à la spécificité du dispositif épistolaire dont la latéralité renvoie à celle du Nebenmensch dont traite le « Projet d’une psychologie », rédigé pour Fliess selon les termes de Freud. L’adresse de la lettre d’amour revêt un caractère d’autant plus spectral lorsque l’autre ne répond plus. De lettre en lettre de Freud, sont reparcourues les différentes étapes du besoin, de la demande et du désir qui ont marqué l’accession de tout sujet au symbolique jusqu’au désengagement de la figure de l’autre idéalisé par lequel il fallut passer pour accéder à une parole singulière, ici L’interprétation du rêve . Et la correspondance amoureuse de connaître un nouveau tournant jusqu’à son tarissement. De ces éléments retirés de la lecture des lettres à Fliess, l’auteure soutient qu’il s’agit bien de lettres d’amour et non pas d’une amitié passionnée.
Mobilité et biodiversité, un espace commun : le trottoir
Authors: Laurant Sophie , Muratet Audrey , Riou Dominique 
Published: December 2019

Et si deux sujets en apparence aussi éloignés que la mobilité et la biodiversité avaient, en ce qui concerne les trottoirs de nos villes, un avenir commun et une grande convergence d’intérêt ? Explications…
Demain, des rues pour tous ?
Authors: Cardon Vincent 
Published: December 2019

Après des décennies d’envahissement de la ville par l’automobile, de plus en plus de voix se font entendre pour rappeler que la rue est à tous et qu’un espace partagé mais donnant la priorité aux modes actifs constitue le concept d’aménagement le plus riche : sûr, durable, sain et agréable. Comment en est-on arrivé là ?
Comparison of Sectioned and Whole Otoliths for Estimating Bluegill Age
Authors: Koch Jeff , Neely Ben , Chance-Ossowski Connor 
Published: December 2019

Abstract
Three readers independently assigned ages to 257 paired sectioned and whole Bluegill Lepomis macrochirus otoliths to examine between-reader precision of age estimates and to compare estimates obtained using the two otolith preparation methods. Percent exact between-reader agreement varied from 93.4% to 96.9% for sectioned otoliths and 92.2% to 94.2% for whole otoliths. Mean coefficient of variation values for between-reader comparisons were &lt; 5.0% for all reader combinations and both otolith preparation methods. Exact agreement between paired whole and sectioned otoliths varied by reader from 82.8% to 85.2%; whereas coefficient of variation values ranged from 7.8% to 8.9%. The only significant departure from a 1:1 relationship for mean age estimates between the two preparation methods occurred for young fish in the estimates of one reader. This bias was not pervasive, as no significant bias was indicated in older fish. Our results suggest that age estimates obtained from sectioned and whole Bluegill otoliths are precise and the time and associated expense of mounting and sectioning Bluegill otoliths may not be necessary as whole otolith ages were generally concordant with sectioned ages to age 8 y.
Potential Effects of Age, Population, and Latitude on Precision of Scale and Otolith Age Estimates of White Crappie in Minnesota
Authors: McInerny Michael C. , Hoxmeier R. John H. , Koenen Bradley D. 
Published: December 2019

Abstract
We calculated between-reader precision of ages estimated with scales and whole otoliths (sagittae) of White Crappie Pomoxis annularis for 10 Minnesota populations, and determined effects of population and mean age on precision. For all samples combined, two experienced readers counted the same number of annuli on 91% of the scales and 92% of the whole otoliths. Mean coefficients of variation equaled 1.8% between scale readers and 3.0% between whole otolith readers. We detected no systematic age-bias between readers of each structure. Agreement between scale readers differed among populations, ranging from 67 to 100% among populations (median = 89%), but agreement also decreased with increasing scale age in six of these populations. Agreement between readers of whole otoliths was unaffected by increasing age of White Crappie, but agreement ranged from 39 to 100% among populations. When compared with other studies, latitude had no influence on precision of whole otolith ages because precision in the Minnesota populations differed little from precision reported for populations in Kentucky and Mississippi. Latitude could be affecting precision in scale age estimates because precision was usually better for the Minnesota populations than for populations in Oklahoma, Kentucky, and Mississippi; however, differences in viewing methods and reader competencies could also explain geographical differences.