bluuebunny/crossref_metadata_2025_split huggingface dataset:
FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA
Authors: Chen Bingxin , Wang Liming , Li Xiaomin , Ren Ci , Gao Chun , Ding Wencheng , Wang Hui 
Published: December 2024

ABSTRACTBackgroundThe incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase.AimsOur study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy.Materials & MethodsWe analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip‐seq and Merip‐qPCR are used to profile m6A transcriptome‐wide. Finally, western blot were performed to identify the regulatory mechanism.ResultsBased on TCGA‐CESC cohort and GEO dataset, FTO expression levels in HPV‐positive cancer patients were significantly higher than those in HPV‐negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip‐seq and Merip‐qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer.ConclusionAll in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
Reliable modelling of the sulphur properties to calculate the process parameters of the Claus sulphur recovery plant
Authors: Ghiasi Mohammad M. , Zendehboudi Sohrab , Mohammadi Amir H. , Nikkhahi Mahdi , Lohi Ali , Chatzis Ioannis 
Published: December 2024

AbstractIn order to handle the overwhelming effects of the removed hydrogen sulphide (H2S) from natural gas and industrial waste gases on the environment, H2S can be converted to elemental sulphur. Among the available processes for sulphur recovery, the most widely employed process is a modified Claus process. In this work, first, least square version of support vector machine (LS‐SVM) approach is utilized for determining the properties of sulphur including heat of vaporization, heat of condensation (S6, S8), heat of dissociation (S6, S8), and heat capacity of equilibrium sulphur vapours as a function of temperature. An illustrative example is given to show the usefulness of the presented computer‐based models with two parameters for designing and operation of the Claus sulphur recovery unit (SRU). According to the error analysis results, predicted values by the proposed intelligent models are in excellent agreement with the reported data in the literature for the aforementioned sulphur properties where the coefficient of determination (R2) is higher than 0.99 for all developed models. The average absolute relative deviation percent (%AARD) is less than 1.3 while predicting the heat capacity of equilibrium sulphur vapours. Other proposed models' predictions show less than 0.2% AARD from the target values. In addition, a mathematical algorithm on the basis of the Leverage approach is proposed to define the domain of applicability of the developed LS‐SVM models. It was found that the presented models are statistically valid and the employed data points for developing the models are within the range of their applicability.
Optimizing Spectrum Efficiency With MIMO NOMA PD Approach in a 5G Cooperative Spectrum Sharing Environment
Authors: Gnana Priya G. , Balasubadra K. 
Published: December 2024

ABSTRACTThe fifth generation (5G) of cellular communication networks has introduced various advanced technologies to address the increasing demand for higher data rates and improved spectrum utilization. One of these technologies, non‐orthogonal multiple access (NOMA), has gained significant attention due to its ability to enhance spectral efficiency by allowing multiple users to share the same time‐frequency resource block. NOMA affords a number of advantageous features including increased spectrum efficiency (SE). It comes in various forms, such as power‐domain (PD) NOMA and code‐domain (CD) NOMA. This paper attentions mainly on enhancing the SE of downlink (DL) PD‐NOMA in a 5G cooperative spectrum sharing environment using single input single output (SISO), massive MIMO (M‐MIMO), and multiple input multiple output (MIMO). Two methods are approached here. In the first one, the NOMA handlers access the free/unconstrained channels using competing channel (C‐Ch) approach, whereas the next one uses dedicated channel (D‐Ch) approach. Five users are considered at distances of 1000, 800, 600, 400, and 200 m from the base station (BS) with different power allocation coefficients at transmitting power of 40 dBm and bandwidth of 70 MHz. Quadrature phase shift keying (QPSK) is used with successive interference cancellation (SIC) at the receiver side and superposition coding (SC) at the transmitter side under frequency selective Rayleigh fading environment. The PD DL NOMA system's results demonstrated that combining 32 × 32 MIMO, 64 × 64 MIMO, and 128 × 128 M‐MIMO in a single cell and the same network with cooperative cognitive radio network (CoCRN) significantly improved the SE reliability. The user Ur5 produces an optimal SE performance of 3.753 bps/Hz/cell for PD DL NOMA with SISO, 5.77 bps/Hz/cell for CoCRN PD DL NOMA with SISO using C‐Ch, and 7.45 bps/Hz/cell for CoCRN DL PDNOMA with SISO using D‐Ch with a 40 dBm transmitting power. Furthermore, the SE for Ur5 (nearest user) was increased to 64%, 67%, and 69%, respectively, using PD‐NOMA with 32 × 32 MIMO, PD‐NOMA with 32 × 32 MIMO using C‐Ch, and DL NOMA PD with 32 × 32 MIMO using D‐Ch. DL PD‐NOMA with MIMO(64 × 64) using D‐Ch improved the SE rate by 77% having transmission power of 40 dBm in comparison with the SE outcome for DL PDNOMA with SISO; however, DL PD‐NOMA with MIMO (64 × 64) most dramatically upgraded the SE rate for Ur5 by 73%. Using C‐Ch and CoCRN DL PD‐NOMA with MIMO (64 × 64), the SE performance was boosted by 76%. The best user, Ur5, had an 82% improvement in SE performance when DL PD‐NOMA with M‐MIMO (128 × 128) was compared to DL NOMA with SISO. With a 40 dBm transmission power, CoCRN DL NOMA with 128 × 128 M‐MIMO using C‐Ch showed an 88% improvement, whereas CoCRN DL PD‐NOMA with M‐MIMO (128 × 128) using D‐Ch experienced an 89% improvement.
Integrated CNN‐LSTM for Photovoltaic Power Prediction based on Spatio‐Temporal Feature Fusion
Authors: Ma Junwei , Huo Meiru , Han Jinfeng , Liu Yunfeng , Lu Shunfa , Yu Xiaokun 
Published: December 2024

ABSTRACTThe accurate prediction of the output power of each power plant is crucial for effective resource deployment. This paper proposes a convolutional neural network‐long short‐term memory (CNN‐LSTM) network integration model based on spatio‐temporal feature fusion. Firstly, the temporal correlation of the PV features of the target power plant and the spatial correlation between the PV power of the target power plant and the PV power of the neighboring power plants are computed. The features are then fused according to the strength of the correlation, which allows the features to be combined with spatial and temporal attributes, which promotes faster and more effective training of the model. Subsequently, an integrated network architecture comprising three individual models, CNN, LSTM, and CNN‐LSTM, is designed. The SENet attention mechanism is utilized to add non‐linear integration weights to the outputs of the individual models. Due to the variability of different neural networks, the prediction results of the integrated model are often higher than the best‐performing individual model. Additionally, we designed different case studies to compare model performance under sunny, rainy, and cloudy conditions. Extensive simulation experiments demonstrate the effectiveness of our proposed integrated approach. When the prediction interval is set to 5 min, the RMSE loss of the integrated model on the test set is reduced by 13.5%, 6.9%, and 5.1% compared to the CNN, LSTM, and CNN‐LSTM models included in the ensemble, respectively.
Pyrolysis kinetics study of nucleic acid detection supplies
Authors: Ma Hongting , Zhou Zhipeng , Deng Na 
Published: December 2024

AbstractTo investigate the pyrolytic behavior of materials used in nucleic acid detection and unravel their chemical reaction mechanisms at a molecular scale, thermogravimetric experiments were conducted on a range of components: polypropylene (PP) sampling tubes, polyamide/acrylonitrile butadiene styrene (PA/ABS) pharyngeal swab sampling heads, ABS pharyngeal swab rods, and mixtures of pharyngeal swab sampling heads and sampling tubes at heating rates of 10, 20, 30, and 40°C/min employing conversion from 0.1 to 0.9 in 0.1 increments. Employing three model‐free methods—Kissinger–Akahira–Sunose, (KAS) Flynn–Wall–Ozawa, and Friedman—the pyrolysis kinetics of individual components and mixtures were analyzed. The average activation energy were obtained to be 144.0–152.7, 211.4–213.5, 163.3–168.7, and 156.6–167.3 kJ/mol, respectively. Two model‐fitting methods—Coats‐Redfern and Criado—were used to elucidate the chemical reaction mechanisms across various heating rates and conversions. The pre‐exponential factor was calculated. The pyrolytic behavior of pharyngeal swabs was simulated, and the results showed that the most accurate kinetic parameters were obtained by the KAS method.
‘I can't relate to it’: Exploring autistic and non‐autistic adults' perceptions of the Australian Physical Activity and Sedentary Behaviour Guidelines
Authors: Thompson C. , Gorey T. , Lawler T. , Watson G. , Wells B. , McVeigh J. A. 
Published: December 2024

AbstractBackgroundDespite sufficient physical activity (PA) being strongly associated with better health outcomes, half of the Australian population does not meet the Australian PA and Sedentary Behaviour Guidelines. This shortfall is more pronounced among autistic adults, who exhibit poorer health outcomes and lower PA levels than non‐autistic adults. Despite these disparities, there is a limited understanding of how autistic and non‐autistic individuals perceive and interpret the PA guidelines.MethodsThis study investigated how autistic and non‐autistic adults perceive and comprehend the Australian PA guidelines. This study used interpretative phenomenological analysis.ResultsA total of 15 autistic and 20 non‐autistic adults were interviewed, and 4 themes that were largely similar between both groups were identified: (1) Lack of Awareness and Engagement with the PA Guidelines, (2) Misinterpretation of Key Terms and Concepts, (3) Perceived lack of Relevance and Relatability of the PA Guidelines and (4) Lack of Inclusivity.ConclusionThe findings underscore the importance of crafting health communication and promotion materials that are more visible, clear, inclusive and engaging for non‐autistic and autistic individuals in Australia.So What?This study highlights the potential for improving the number of people correctly understanding the PA guidelines by addressing dissemination methods, knowledge and interpretation of the guidelines as some components of the multifaceted process required to achieve behaviour change.
Associations Between Food Security, Housing and Health in South Australia
Authors: Phan Tuong‐Vi , D'Onise Katina , Nori Annapurna , Venugopal Kamalesh , Joshi Suresh 
Published: December 2024

ABSTRACTIssue AddressedFood security is becoming increasingly difficult to achieve for many households. Research has shown that food insecurity is associated with socioeconomic disadvantage, including housing pressures, and may contribute to poor health outcomes. There is lack of data on these associations in the South Australian setting, where food security is not consistently monitored.MethodsA population health survey was administered to South Australian participants in April 2023. Descriptive analysis was conducted on data regarding food insecurity, housing circumstances, chronic and mental health conditions. Multivariate logistic regression analysis was performed to assess associations between food security and health outcomes.ResultsFrom a sample of 3002 participants, 16.4% reported low and very low food security. These participants tended to be renting, facing housing cost pressures, and lacking infrastructure to store and prepare food. When controlling for confounders, food insecurity was found to be associated with increased likelihood of having at least one chronic condition, mental health condition, and decreased overall wellbeing.ConclusionFood security is itself a determinant of health. Regular monitoring of the prevalence of household food insecurity and addressing the structural factors influencing food affordability and availability are required. Further research on its links to health outcomes is warranted.So What?Evidence‐based action to address food insecurity will become more pressing as the crises of cost‐of‐living, housing, health system pressures and environmental disasters converge.
Impact of Cybersecurity Disclosure Frequency on Stock Price Crash Risk
Authors: Wu Huaping , Ma Ming , Zhang Jidong 
Published: December 2024

ABSTRACTBy exploring the relationship between stock price crash risk and the frequency of cybersecurity disclosures in financial reports, we present evidence that cybersecurity disclosure does matter because its frequency increases stock price crash risk. We analyze the association between cybersecurity disclosure and stock price crash risk from the perspective of two different theoretical lenses: information asymmetry and investor sentiment. We perform textual analysis on the Chinese A‐shares public companies’ cybersecurity disclosure in financial reports during 2017–2022. We find that the more cybersecurity disclosures in financial reports, the higher the stock price crash risk. Further findings reveal that the effect of the frequency of cybersecurity disclosure on stock price crash risk is more significant in non‐Big‐4 audit companies and companies with lower analyst coverage. These findings imply that the market presents the clear idea that cybersecurity disclosure's negative impact to stock price crashes would be greater than the positive impact under the current settings of the volunteer disclosure policies.
DFT investigation on thermoelectric, electronic, optoelectronic, elastic, and structural properties of sodium‐based halide double perovskites Rb2NaSbZ6 (Z = Cl, Br, and I)
Authors: Shah Syed Hatim , Song Peng , Huang Taihong , Shakeel Shakeel , Lu Jiansheng , Awadh Bahajjaj Aboud Ahmed , Murtaza G. 
Published: December 2024

AbstractSodium‐based halide double perovskites (HDPs) present a promising alternative to Pb‐based perovskites for safe solar and thermal energy conversion devices due to their high durability and non‐toxic elements. This study examines the electronic, thermoelectric, elastic, optoelectronic, and structural properties of Rb2NaSbZ6 (Z = I, Br, Cl) double perovskite compounds using density functional theory (DFT). These compounds, characterized by a cubic structure, show increasing structural parameters as halogens are substituted from chlorine to iodine. Structural stability is confirmed by evaluating the enthalpy of formation, Gibbs free energy, Born and Huang criteria, and tolerance factor. Pugh's ratio indicates the ductile nature of the compounds. All investigated halide compounds exhibit an indirect band gap ranging from 3.9 to 2.34 eV, with valence and conduction band extrema located at different symmetry points, and a higher effective mass of holes is noted. This study also analyzes the refractive index, optical loss, light absorption, and polarization across the energy range of 0–10 eV. The spectral characteristics indicate that these HDPs are suitable for optoelectronic and photovoltaic devices due to their absorption in the visible and near‐ultraviolet spectra. High figures of merit (0.45–0.6) derived from power factor and thermal conductivity calculations suggest the potential of these compositions as thermoelectric devices. These findings provide a comprehensive understanding of these materials, facilitating their further deployment.
Challenges of MS‐based small extracellular vesicles proteomics
Authors: Fochtman Daniel , Marczak Lukasz , Pietrowska Monika , Wojakowska Anna 
Published: December 2024

AbstractProteomic profiling of small extracellular vesicles (sEV) is a powerful tool for discovering biomarkers of various diseases. This process most often assisted by mass spectrometry (MS) usually lacks standardization and recognition of challenges which may lead to unreliable results. General recommendations for sEV MS analyses have been briefly given in the MISEV2023 guidelines. The present work goes into detail for every step of sEV protein profiling with an overview of factors influencing such analyses. This includes reporting and defining the sEV source and vesicle isolation, protein solubilization and digestion, ‘offline’ and ‘online’ sample complexity reduction, the analysis type itself, and subsequent data analysis. Every stage in this process affects the others, which could result in different outcomes. Although characterization and comparisons of different sEV isolation methods are known and accessible and MS‐based profiling details are provided for cell or tissue samples, no consensus work has been ever published to describe the whole process of sEV proteomic analysis. Reliable results can be obtained from sEV profiling provided that the analysis is well planned, prepared for, and backed by pilot studies or appropriate research.
Men who have sex with men perceiving that sex with women carries the greatest risk of HIV acquisition: results from a mixed‐methods systematic review in sub‐Saharan Africa
Authors: Fiorentino Marion , Dos Santos Marie , Eubanks August , Yanwou Nathan , Laurent Christian , Roux Perrine , Spire Bruno 
Published: December 2024

AbstractIntroductionIn sub‐Saharan Africa (SSA), men who have sex with men (MSM) often have female sexual partners. Their overall risk of acquiring HIV is higher with male partners. Risk perception is associated with HIV knowledge, sexual risk and preventive behaviours. This synthesis aimed to summarize existing data about HIV knowledge and perceived HIV acquisition risk regarding sex with men and with women in MSM in SSA.MethodsWe conducted a systematic literature review of MSM's relationships with women in SSA (PROSPERO‐CRD42021237836). Quantitative and qualitative data related to MSM's perceived risk from sex with men and with women and HIV knowledge (published up to 2021) were selected and synthesized.ResultsTwenty studies were selected. More MSM perceived that the greatest risk of HIV acquisition came from heterosexual/vaginal sex than from homosexual/anal sex (53% vs. 15%; 51% vs. 39%; 42% vs. 8%; 27% vs. 25%; 43% vs. 11%; 23% vs. 13%; 35% vs. 16%, cumulative sample n = 4396, six countries). A higher proportion of MSM received preventive information on heterosexual HIV transmission than on homosexual transmission (79% vs. 22%; 94% vs. 67%; 54% vs. 19%; cumulative sample n = 1199, four countries). The qualitative synthesis (eight studies) highlighted biology‐ and behaviour‐based misconceptions leading MSM to perceive lower or negligible HIV risk from sex with men, compared to sex with women. These misconceptions were partly fuelled by the predominant focus on heterosexual and vaginal HIV transmission in HIV prevention information.DiscussionCommon misconceptions regarding sexual risk between men remain unaddressed by the heteronormative messaging of HIV prevention. Underestimation by MSM of their HIV acquisition risk with male partners can pose significant barriers to effective HIV preventive behaviours and strengthen the transmission risk from MSM to their female partners.ConclusionsImproving access of MSM to tailored HIV prevention information and tools that address their practices with male and female partners is crucial. Integrating messages about anal sex into broader public health initiatives, including sexual health programmes targeting the general population, is essential. Further research in diverse settings in SSA is necessary to gain a greater understanding of the drivers and implications of HIV risk perception in MSM.
Towards a Meaningful Understanding of Organizational Leaders' Localized and Contextualized Implementation of UNSDGs in Bahrain's Changing Energy Sector Businesses
Authors: Mendy John , Al Ghanem Nawaf Husain 
Published: December 2024

ABSTRACTDespite Network Leadership scholarship's emphasis on localizing and contextualizing leadership practices during organizational change, there is a dearth in the current theoretical framings on “how” to address the implementation failure of localization and contextualization towards broader SDGs/organizational sustainability. This paper fills this gap by offering deeper insightful theoretical and practical understanding of how organizational leaders can address socio‐economic and ecological sustainability concerns, and how a more meaningful reconceptualization and implementation of leadership practices can help Business and Management academics and practitioners address the organizational growth, human, and ecological well‐being dilemma in the energy sector. By drawing on Network Leadership, SDG, organizational change literature and 26 senior leaders' semi‐structured interviews, this study uses (Braun and Clarke's 2006) Thematic Analysis Procedure to resolve the theoretical and practical implementation lag in Business and Management scholarship. We contribute 4 novel implementation practices: (1) Operational; (2) strategic; (3) cultural and (4) interorganizational knowledge exchange alignment and a model on wider socio‐economic‐ecological well‐being. Showing ‘what’ leadership characteristics are needed and “how” to meaningfully reconceptualize the dominant localization and contextualization model of organizational change towards broader sustainability goals has been practically and scholarly overdue.
Solid‐state fermentation of corn wet distiller grains and wheat bran with Trichoderma reesei and Candida utilis for improving feed value
Authors: Fan Weiwei , Liu Kehan , Xu Yongping , Chi Zhanyou 
Published: December 2024

AbstractBACKGROUNDSolid‐state fermentation is one of the most effective methods for the high‐value utilization of agro‐industrial by‐products. Co‐fermentation of wet distiller grains and agricultural waste is an effective way to mitigate the feed shortage caused by corn consumption for bioethanol. It is still challenging to convert wet distiller grains and wheat bran to easily accessible carbon sources and adjust the balanced proportion of amino acids together by fermentation.RESULTSFermentation time, strain ratio, and the addition of ammonium sulfate have been verified to be the important factors influencing the symbiosis of Trichoderma reesei (T. reesei) and Candida utilis (C. utilis) in a mixed system of wet distiller grains and wheat bran. The optimum conditions were fermentation for 8 days, 2:1 (T. reesei: C. utilis) strain ratio, and addition of 4% ammonium sulfate. After fermentation, the cellulose degradation proportion reached 39.1%, and the hemicellulose degradation proportion was 13.1%. The protein content improved by 29.6%. The lysine content increased by 126%, reaching 11.3 g·kg−1. The threonine content increased from 6.10 to 10.3 g·kg−1. The phytate content was decreased to 3.97 g·kg−1. The in vitro digestibility of dry matter and protein increased to 62.8% and 76.1%, respectively.CONCLUSIONSThese results indicated the feasibility of improving the feeding value of wet distiller grains and wheat bran by the symbiosis of T. reesei and C. utilis. © 2024 Society of Chemical Industry.