bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood
Authors: Wang Yue , Jiang Wenbo , Dong Qiuying , Zhao Yue , Chen Yingying , Sun Changhao , Sun Guoli 
Published: August 2020

AbstractIntroductionDichloroacetic acid (DCA), a by‐product of disinfection in drinking water, is a multiple organ carcinogen in humans and animals. Still, little research on its neurotoxicity and its underlying mechanism has not been elucidated.MethodsSprague Dawley rats were intragastrically treated with DCA at 10, 30, 90 mg/kg body weight from pregnancy till delivery. At eight weeks of age of pups, we assessed cognitive performance using the standard behavioral tests. And the hippocampus structure and ultrastructure were evaluated using light and electron microscope. The oxidative stress indicators and neuroinflammation factors were measured with the corresponding kits. The mRNA and protein of synaptic factors were detected using RT‐PCR and Western blot.ResultsThe results indicated that maternal weight gain and offspring birthweight were not significantly affected by DCA. However, behavioral tests, including morris water maze and step down, showed varying degrees of changes in DCA‐treated pups. Additionally, we found significant differences in hippocampal neurons by histomorphological observation. Biochemical analysis results indicated superoxide dismutase (SOD) and catalase (CAT) activities, as well as reactive oxygen species (ROS), nitric oxide (NO), and reduced glutathione (GSH) levels, were affected by DCA accompanying with DNA damage. Moreover, the results showed that the neuroinflammation factors (TNF‐α, IL‐6, IL‐1β) in DCA treatment groups increased significantly compared with the control pups. And we also found that DCA treatment caused a differential modulation of proteins (BDNF, cAMP‐response element‐binding protein1 (CREB1), p‐CREB1, postsynaptic density‐95 (PSD‐95), synapsin I, p‐synapsin I), and mRNA (BDNF, PSD‐95).ConclusionsTaken together, these results above showed that oxidative stress, neuroinflammation response, and weakened synaptic plasticity in pups hippocampus induced by fetal exposure to DCA could damage the function of memory and cognition in the adulthood.
Do online environments promote sufficiency or overconsumption? Online advertisement and social media effects on clothing, digital devices, and air travel consumption
Authors: Frick Vivian , Matthies Ellen , Thøgersen John , Santarius Tilman 
Published: August 2020

AbstractSustainable consumption is increasingly shaped by online environments. Everyday exposure to online advertisement and social media content by peers may influence individual consumption decisions. By representative online surveys (N = 2,694), we examined how perception of online environments influences individual consumption levels of clothing, digital devices and leisure air travel, mediated by individual aspiration levels, personal and social norms. Structural equation modeling confirms relationships between perceived consumption‐promoting online content and consumption levels, fully mediated through aspiration levels. Sufficiency‐promoting online content is associated with higher social and personal norms for sufficiency, but neither of the latter are linked to aspiration or consumption levels. These findings are consistent with the hypothesis that aspiration levels and consumption decisions are influenced by consumption‐promoting online content. Due to the use of cross‐sectional data, it cannot be ruled out that these results reflect that more consumption‐oriented individuals pay more attention to consumption‐promoting online content. Hence, the dominant causal direction needs to be determined by experimental or longitudinal methods.
ERO1L promotes NSCLC development by modulating cell cycle‐related molecules
Authors: Shi Xiujuan , Wu Jiawen , Liu Yi , Jiang Yuxiong , Zhi Changjiang , Li Jue 
Published: August 2020

AbstractLung cancer is the leading cause of cancer‐related death worldwide. Previous studies revealed that endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) played critical roles in the malignant behaviors of several cancer types, but its role in non‐small cell lung cancer (NSCLC) remained unclear. In this study, we identified 26 upregulated and 102 downregulated genes in NSCLC using bioinformatics analyses, and these genes were enriched in the biological processes of the cell cycle. ERO1L was remarkably upregulated in NSCLC and overexpression of ERO1L was associated with poor prognosis of NSCLC. ERO1L deficiency markedly suppressed NSCLC cell proliferation, colony formation, migration, and invasion. ERO1L depletion caused a dramatically decreased expression of cell cycle‐related factors in NSCLC cells. Collectively, our data validated that ERO1L could function as a tumor promoter in NSCLC, indicating the potential of targeting ERO1L for the treatment of NSCLC.
Leukoreduction and hydroxyurea in malignant pertussis: A case series
Authors: Aldairi Nedaa , Alali Hamza , Kazzaz Yasser 
Published: August 2020

AbstractWe report five cases of malignant pertussis, a rare but life‐threatening illness. Current therapies include supportive care and leukoreduction. Notably, leukoreduction might be more effective when initiated prior to the development of organ failure and pulmonary hypertension.
Methane Pyrolysis for CO2‐Free H2 Production: A Green Process to Overcome Renewable Energies Unsteadiness
Authors: Sánchez‐Bastardo Nuria , Schlögl Robert , Ruland Holger 
Published: August 2020

AbstractThe Carbon2Chem® project aims to convert exhaust gases from the steel industry into chemicals such as methanol to reduce CO2 emissions. Here, H2 is required for the conversion of CO2 into methanol. Although much effort is put to produce H2 from renewables, the use of fossil fuels, especially natural gas, seems to be fundamental in the short term. For this reason, the development of clean technologies for the processing of natural gas with a low environmental impact has become a topic of utmost importance. In this context, methane pyrolysis has received special attention to produce CO2‐free H2.
Separating the Driving Force on Estuary Nutrient Evolution
Authors: Wang Hua , Yuan Weihao , Yan Huaiyu , Zhou Fengnian , Li Bao , Zhuang Wei , Zeng Yichuan , Kaisam John Paul 
Published: August 2020

AbstractThe Yangtze river estuary (YRE) of China is selected as the research area. The evolution of nutrient load in YRE from 2004 to 2016 is examined against field investigated data. The entropy value‐based method is proposed to decouple the forces driving the dynamics of the nutrients. The results indicated that: 1) The nutrient driving force sequence in YRE is mainstream boundary (MB, 34.57%) > regional pollutant boundary (PB, 34.48%) > self‐purification (SP, 20.26%) > sediment release (SR, 7.00%) > atmospheric deposition (AD, 3.68%). 2) The strength of the MB is weakened by the decreasing distance to the entrance of the river and the geographical position is significantly correlated with the force of the PB. 3) The weight of SP range from 13.8% to 28.3% and the seasons have important influence for SP force. In flood seasons SP is strengthened by 12.3% on average. 4) SR and AD do not play a significant role in the nutrient evolution, but forces fluctuated with space‐time conditions. 5) As different forms of nutrients undergo different physical, chemical, and biological processes in water, the forces varied with nutrient factors.
Associations between supernormality (‘faking good’), narcissism and depression: An exploratory study in a clinical sample
Authors: De Page Louis , Merckelbach Harald 
Published: August 2020

AbstractWe explored underreporting of mental health symptoms and its correlates in adults receiving psychological treatment. We administered the Supernormality Scale (SS), the Minnesota Multiple Personality Inventory‐2 (Restructured Form, MMPI‐2‐RF), the Narcissistic Personality Inventory (NPI) and the Beck Depression Inventory‐II (BDI‐2) to 147 patients at the start of their treatment. Supernormality (i.e., denial of common symptoms) was positively associated with MMPI‐2(‐RF) faking good parameters supporting the construct validity of the SS. Narcissism was negatively related to self‐reported depression symptoms, but this association failed to reach significance (r = −.15, p = .07). This suggests that patients high on grandiose/overt narcissism might tend to deny common symptoms. The link between supernormality and depression symptoms as measured by the BDI‐2 was substantial and negative (r = −.72). Our data suggest that supernormality is associated with constricted self‐reports of depression. Given the clinical relevance of symptom underreporting, our preliminary findings require a large‐scale replication.
Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants
Authors: Zhang Youjun , Krahnert Ina , Bolze Antje , Gibon Yves , Fernie Alisdair R. 
Published: August 2020

AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these compounds. Here, we describe a highly sensitive and selective ion‐pairing HPLC method with fluorescence detection to quantify adenine nucleotides in plants. In addition, nicotinamide adenine dinucleotide is a crucially important redox‐active substrate for multiple catabolic and anabolic reactions with the ratios of NAD+/NADH and NADP+/NADPH being suggested as indicators of the general intracellular redox potential and hence metabolic state. Here, we describe highly sensitive enzyme cycling−based colorimetric assays (with a detection limit in the pmol range) performed subsequent to a simple extraction procedure involving acid or base extraction to allow the measurement of the cellular levels of these metabolites. © 2020 The Authors.Basic Protocol 1: Preparation of plant material for the measurementBasic Protocol 2: Measurement of ATP, ADP, and AMP via HPLCBasic Protocol 3: NAD+/NADP+ measurementsBasic Protocol 4: NADH/NADPH measurementsBasic Protocol 5: Data analysis and quality control approaches
Effects of elevated CO2 and warmer temperature on early season field‐grown cotton in high‐input systems
Authors: Broughton Katrina J. , Bange Michael P. , Baker Jeffrey T. , Yates Charles , Tan Daniel K.Y. , Tissue David T. , Payton Paxton 
Published: August 2020

AbstractChanges in temperature and CO2 under the scenarios of climate change present a challenge to crop production and may have significant impacts on the yield of cotton (Gossypium hirsutum L.) crops. The aims of this study were to (a) investigate the use of novel chambers to evaluate the impacts of climate change, specifically warmer temperatures combined with elevated atmospheric CO2 concentration ([CO2]), on field‐grown plants; (b) compare the combined effects of elevated [CO2] and temperature on leaf‐level photosynthetic rate and plant biomass; and (c) assess the effects of elevated [CO2] and warmer temperature on soil water content and leaf‐level water‐use efficiency (Asat/E). Canopy evapotranspiration and assimilation (CETA) chambers were used to elevate [CO2] in the field over two consecutive seasons, but also generated higher air temperatures (on average 2–4 °C warmer) at ambient (CA: 400 μl L−1) and elevated [CO2] (CE: 650 μl L−1) from ∼44 days after planting (DAP) until 72 DAP. Elevated [CO2] increased early stage vegetative biomass by 34–68% in well‐watered, field‐grown cotton growing at warmer temperatures. Despite increased Asat/E with CE, there were minimal changes in leaf‐level biochemistry (estimated from gas exchange) and volumetric soil water content (VSWC) over the 28 d period, potentially the result of the combination of greater biomass and improved Asat/E. We observed increased early season crop growth of cotton grown in a changing climate; however, studies are needed to assess the effects of elevated CO2 and temperature on cotton production over a full growing season in the field.
Doing well by doing good: How corporate environmental responsibility influences corporate financial performance
Authors: Zhang Yuanyuan , Ouyang Zhe 
Published: August 2020

AbstractThe natural resource‐based view suggests a relationship between corporate environmental responsibility (CER) and corporate financial performance (CFP), because intangible assets accrued by a firm constitute competitive advantages. However, the role of corporate reputation as a valuable intangible asset in the CER–CFP link has yet to be examined. We fill this gap by examining the effect of a firm's reputation in terms of prominence and favorability in interactively mediating the CER–CFP link. Using a sample of 10,995 firm‐year observations in China, we find that CER enhances a firm's prominence and favorability, through which CER indirectly improves CFP. Additionally, the results of moderated mediation analysis indicate that the indirect effect of CER on CFP via improving prominence (favorability) is more positive and significant in high levels of favorability (prominence) than in low levels.
Molecular sex identification of Malaysian White‐Nest Swiftlet (Aerodramus fuciphagus Thunberg, 1812)
Authors: Osman Muhammad Amin , Sugnaseelan Sumita , Panandam Jothi Malar , Ab Ghani Nurul Izza 
Published: August 2020

AbstractThe difficulty in differentiating the sex of monomorphic bird species has made molecular sexing an important tool in addressing this problem. This method uses noninvasively collected materials such as feathers and may be advantageous for sexing endangered as well as commercialized bird species. In this study, seven primer sets for sexing birds were screened in Aerodramus fuciphagus using a total of 13 feather samples that were randomly selected from the state of Perak, Malaysia. From the screening analysis, only one primer set (P8/WZ/W) successfully differentiated the sex of A. fuciphagus. PCR amplification produced a single 255‐bp DNA fragment for males which was derived from CHD‐Z (CHD gene region in the sex chromosome Z), while for the females it produced two fragments (144 and 255 bp). The 144‐bp fragment was from CHD‐W (CHD gene region in the sex chromosome W). Results from sequencing showed no variations in the base sequences of the CHD‐W and CHD‐Z amplified fragments within the same sexes, except for one male sample (A23) where at position 166, a base substitution occurred (G → A). Phylogenetic analysis of CHD‐W showed that four (Apodiformes; Gruiformes; Passeriformes; and Pelecaniformes) out of the five orders investigated had formed four clear clusters within their orders, including the studied order: Apodiformes. Whereas in CHD‐Z, four (Accipitriformes; Columbiformes; Galliformes; and Passeriformes) out of five orders investigated formed four clear clusters within their orders, excluding the studied order. In addition, A. fuciphagus and Apus apus (both Apodiformes) showed less divergence in CHD‐W than CHD‐Z (0% c.f. 9%). The result suggests that in A. fuciphagus, CHD gene evolution occurred at a higher rate in males (CHD‐Z) compared to females (CHD‐W). This finding may be useful for further studies on sex ratio and breeding management of A. fuciphagus.
Trade‐offs affect the adaptive value of plasticity: stronger cannibal‐induced defenses incur greater costs in toad larvae
Authors: DeVore Jayna L. , Crossland Michael R. , Shine Richard 
Published: August 2020

AbstractAdaptive developmental plasticity allows individuals to match their phenotype with their environment, increasing fitness where threats are inconsistently present. However, despite clear advantages of plasticity, adaptive traits are not ubiquitously nor infinitely plastic. Trade‐offs between benefits and costs or limits are therefore theoretically necessary to constrain the evolution of plastic responses. Systems in which extreme risk can be reliably detected are ideal for investigating trade‐offs, as even costly responses may be adaptive where risk is severe. Cane toads (Rhinella marina) are abundant in Australia and produce large clutches (frequently >10,000 eggs), but asynchronous breeding and rapid development result in variable larval densities within breeding pools. In the field, we found that cannibalism by older cohorts often reduces the survival of conspecific eggs and newly hatched pre‐feeding larvae (“hatchlings”) by >99%, as feeding larvae (“tadpoles”) use chemical cues from the relatively immobile hatchlings to locate and consume them. After hatchlings become free‐swimming, however, they cannot be cannibalized. Hatchlings can reduce this period of vulnerability by accelerating development when they detect cannibal cues. However, this developmental acceleration decreases initial tadpole mass, reduces subsequent survival, growth, and development, affects behavior, and compromises feeding structures. Reaction norms differ among clutches, and greater developmental acceleration is followed by greater impairment of larval function in plastic clutches, whereas nonresponsive clutches are unaffected by cue exposure. More plastic clutches ultimately exhibit both poorer performance and greater variation among siblings in exposed and (to a lesser degree) control treatments. Variation among clutches in tadpole viability is driven by differences in plasticity rather than phenotype; fitness reductions are linked to developmental acceleration, not rapid development per se. Clutches with intrinsically slow pre‐feeding developmental rates exhibit stronger acceleration (i.e., steeper reaction norms), but clutches with intrinsically rapid development reach invulnerable stages more quickly than those that accelerate development. As a result, high cannibalism risk may favor canalized rapid development rather than facultative developmental acceleration. Cannibalism plays an important role in the recruitment of this invasive species, and hatchling defenses against this threat demonstrate how the limits and costs associated with an inducible defense can favor canalized defenses over phenotypic plasticity.
Decellularized gastric matrix as a mesh for gastric perforation repair
Authors: Feng Liang , Hu Yi‐Lin , Ma Peng , Feng Ying , Guo Yi‐Bing , Huang Hua , Li Peng , Mao Qin‐Sheng , Xue Wan‐Jiang 
Published: August 2020

AbstractThe development of novel materials with effective defect‐repairing properties will help avoid subtotal gastrectomy in patients with large gastric perforations. We prepared perfused decellularized gastric matrix (PDGM) and analyzed its components, spatial structure, biomechanics, cytotoxicity, and histocompatibility to validate its efficacy in the repair of gastric perforation. PDGM retained large amounts of gastric extracellular matrix, while residual glandular cells and muscle fibers were not found. The spatial structure of the tissue was well preserved, while the DNA and glycosaminoglycan contents were significantly decreased compared with normal gastric tissue (p < .01). There was no obvious deformation of the spatial structure and tissue elasticity of PDGM after sterilization by Cobalt‐60 irradiation. The PDGM had good histocompatibility. PDGM was then used to repair a rat gastric perforation model. Radiography of the upper gastrointestinal tract at 24 hr postoperatively revealed no contrast agent leakage. There was evidence of early fibroblast proliferation, which was complicated by capillary regeneration. The hyperplastic gastric gland was slightly disarranged after repair. Defects of the muscular layer also healed a little with the regeneration process. PDGM is a nontoxic biocompatible biological mesh that may be useful for repairing relatively large gastric defects.
The protective effect of vitamin U on valproic acid‐induced lung toxicity in rats via amelioration of oxidative stress
Authors: Oztay Fusun , Tunali Sevim , Kayalar Ozgecan , Yanardag Refiye 
Published: August 2020

AbstractVitamin U (Vit U) is a novel free‐radical scavenger. The protective effect of Vit U on valproic acid (VPA)‐induced lung damage was examined. Rats were divided into four groups: control rats; rats given Vit U (50 mg/kg/d, by gavage) for 15 days; rats treated with VPA (500 mg/kg/d, intraperitoneally) for 15 days; and rats were given VPA + Vit U (in same dose and time). On the 16th day of the experiment, the lungs were collected from rats. Lung structure, pulmonary oxidant/antioxidant parameters and Nrf2, α‐SMA, and collagen‐1 were evaluated by microscopic and biochemical analysis. Additionally, it was determined the interactions of Vit U with Nrf2 and Keap1 by in silico analysis. VPA administration increased lipid peroxidation and the activity of lactate dehydrogenase and myeloperoxidase. However, it decreased the glutathione level, and the activities of glutathione peroxidase, glutathione‐S‐transferase, catalase, and superoxide dismutase. VPA‐mediated oxidative stress prompted structural distortion and fibrotic alterations in the lung. Vit U supplementation reversed structural and biochemical alterations, induced antioxidant system through Nrf2 activation, and attenuated fibrosis by reducing collagen expression in VPA‐administered rats. However, Vit U pretreatment was unable to reduce α‐SMA levels in the lung of VPA‐treated rats. Molecular docking analysis showed the binding of Vit U to ETGE motif leads to dissociation of Nrf2 from the Nrf2/Keap1 complex and its transfer to nuclei. In conclusion, Vit U attenuated VPA‐induced tissue damage by restoring antioxidative systems through amelioration of Nrf2 activity in the lung under oxidative stress.
Temperature‐dependent kinetics of the simplest Criegee intermediate reaction with dimethyl sulfoxide
Authors: Li Yu‐Lin , Lin Chun‐Yu , Lin Yen‐Hsiu , Lin Jim Jr‐Min 
Published: August 2020

AbstractCriegee intermediates are thought to play roles in atmospheric chemistry, including OH radical formation, oxidation of SO2, NO2, etc. CH2OO is the simplest Criegee intermediate, of which the reactivity has been a hot topic. Here we investigated the kinetics of CH2OO reaction with dimethyl sulfoxide (DMSO) under 278–349 K and 10–150 Torr. DMSO is an important species formed in the oxidation of dimethyl sulfide in the biogenic sulfur cycle. The concentration of CH2OO was monitored in real‐time via its mid‐infrared absorption band at about 1,286 cm−1 (Q branch of the ν4 band) with a high‐resolution quantum cascade laser spectrometer. The 298 K bimolecular rate coefficient was determined to be k298 = (2.3 ± 0.3) × 10−12 cm3/s at 30 Torr with an Arrhenius activation energy of −3.9 ± 0.2 kcal/mol and a weak pressure dependence for pressures higher than 30 Torr (k298 = (2.8 ± 0.3) × 10−12 cm3/s at 100 Torr). The reaction is speculated to undergo a five‐membered ring intermediate, analogous to that of CH2OO with SO2. The negative activation energy indicates that the rate‐determining transition state is submerged. The magnitude of the reaction rate coefficient lies in between those of CH2OO reactions with (CH3)2CO and with SO2.