bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogas production by co‐digestion of municipal wastewater and food waste: Performance in semi‐continuous and continuous operation
Authors: Ounsaneha Weerawat , Rattanapan Cheerawit , Suksaroj Thunwadee Tachapattaworakul , Kantachote Duangporn , Klawech Wichuda , Rakkamon Tanawat 
Published: July 2020

AbstractMunicipal wastewater has recently attracted interest in relation to anaerobic wastewater treatments. Biogas production with co‐digestion of mixed substrates has been proposed and has many potential benefits for municipal wastewater. The aim of this research was to assess the performance of biogas production during co‐digestion of municipal wastewater and food waste under semi‐continuous and continuous operation with various hydraulic retention times (HRTs). A laboratory‐scale continuous stirred tank reactor (CSTR) at room temperature operation (27–32°C) was employed in this research. The highest methane yields of 167.41 ± 66.52, 194.35 ± 85.44, and 214.81 ± 85.44 ml/g‐Vs were found in semi‐continuous mode, respectively, at 30, 10, and 10 days of HRTs with a 10:90 ratio of municipal wastewater to food waste (based on TS). Result finding of optimum condition (10 days of HRTs) presented a methane yield of 485.58 ± 82.35 ml/g with continuous operation. Hence, food waste has practical implications for use as a co‐substrate with the optimization condition of HRT and operation mode for biogas production from municipal wastewater.Practitioner points

Food waste has good potential for use as a co‐substrate for biogas production from municipal wastewater.

HRT reduction from 30 to 10 days in semi‐continuous, biogas production from municipal wastewater and food waste increased by 59%.

Co‐digestion of municipal wastewater and food waste with continuous mode and 10 days of HRT was the effective biogas production.
Phase transitions of neutral planar hairy AdS black holes
Authors: Anabalon Andres , Astefanesei Dumitru , Choque David , Edelstein Jose D. 
Published: July 2020

AbstractWe investigate the phase diagram of a general class of 4-dimensional exact regular hairy planar black holes. For some particular values of the parameters in the moduli potential, these solutions can be embedded inω-deformed$$ \mathcal{N} $$N= 8 gauged supergravity. We construct the hairy soliton that is the ground state of the theory and show that there exist first order phase transitions.
Therapieansprechen auf intraläsionale Steroidinjektionen bei granulomatöser Entzündungsreaktion nach Tätowierungen
Authors: Cussigh Christiane S. , Toberer Ferdinand , Enk Alexander , Haenssle Holger A. , Fink Christine 
Published: July 2020

ZusammenfassungTätowierungen inklusive Permanent-Make-up können diverse Komplikationen wie virale oder bakterielle Infektionen sowie allergische und entzündliche Reaktionen nach sich ziehen. Bei Letzteren weist die Histologie neben exogenem Pigment ein Entzündungsinfiltrat auf, das je nach Reaktionsmuster lymphozytär oder histiozytär-granulomatös dominiert sein kann. Nachfolgend wird über die erfolgreiche Therapie mittels intraläsionaler Triamcinolonacetonid-Injektionen bei granulomatöser Entzündungsreaktion nach Tätowierungen in 2 Fällen berichtet.
Pharmakotherapie der Alkoholentwöhnung: Update und neue Entwicklungen
Authors: Soyka Michael , Rösner Susanne 
Published: July 2020

ZusammenfassungBislang sind nur wenige Medikamente zur pharmakologischen Rückfallprophylaxe der Alkoholabhängigkeit zugelassen. Neben dem in Deutschland nicht mehr vertriebenen Disulfiram sind es die Opioidantagonisten Naltrexon und Nalmefen sowie das vermutlich über glutamaterge Neurone wirkende Acamprosat. Baclofen und γ‑Hydroxybutyrat (GHB) sind in einzelnen Ländern zugelassen. Wirkstoffe wie z. B. Vareniclin, Gabapentin und Topiramat können für die Rückfallprophylaxe der Alkoholabhängigkeit von Interesse sein, jedoch ist bislang keine Zulassung erfolgt. Vor dem Hintergrund der zur Revision anstehenden S3-Leitlinie zur Diagnose und Behandlung alkoholbezogener Störungen wird der heutige Kenntnisstand zur Pharmakotherapie der Alkoholabhängigkeit dargestellt.
Anti-thrombotic strategies in patients with atrial fibrillation undergoing PCI
Authors: Schäfer Andreas , Flierl Ulrike , Bauersachs Johann 
Published: July 2020

AbstractTriple anti-thrombotic therapy combining oral anticoagulation and dual anti-platelet therapy following percutaneous coronary intervention in patients with atrial fibrillation was considered as standard and recommended by guidelines. While bleeding risk is considerable with that approach, data for efficacy are scare. Several trials assessed the possibility of reducing anti-thrombotic treatment by mainly shortening the exposure to acetylsalicylic acid. Dropping one of the anti-platelet components might increase the risk of stent thrombosis, myocardial infarction or stroke. Despite that fear, the recent trials’ primary endpoint was major and/or clinically-relevant non-major bleeding. We review data on major bleedings, intracranial bleedings and major adverse cardiovascular events from the published reports. We demonstrate that Non-Vitamin K oral anticoagulant (NOAC)-based strategies compared to VKA-based triple therapies significantly reduce the risk for TIMI-major bleedings by 39% and for intracranial bleedings by 66%, while they did not increase the risk for overall ischemic or embolic events. However, recent meta-analyses indicate an increased risk for stent thrombosis with less intense anti-thrombotic therapy. While the overall incidence rate for stent thrombosis is rather low, relative increases by about 30–60% are reported, but they did not translate into adverse clinical net-benefit ratios. This review highlights that using certain NOAC regimens proven effective for stroke prevention in AF can reduce the rate of bleeding without increasing ischemic or embolic events. Furthermore, additive ASA in triple anti-thrombotic regimens should be limited to 1 month and individual weighing of ischemic versus bleeding risk during the first 30 days seems to be reasonable.
The impact of time-updated resting heart rate on cause-specific mortality in a random middle-aged male population: a lifetime follow-up
Authors: Cui Xiaotong , Mandalenakis Zacharias , Thunström Erik , Fu Michael , Svärdsudd Kurt , Hansson Per-Olof 
Published: July 2020

AbstractBackgroundA high resting heart rate (RHR) is associated with an increase in adverse events. However, the long-term prognostic value in a general population is unclear. We aimed to investigate the impact of RHR, based on both baseline and time-updated values, on mortality in a middle-aged male cohort.MethodsA random population sample of 852 men, all born in 1913, was followed from age 50 until age 98, with repeated examinations including RHR over a period of 48 years. The impact of baseline and time-updated RHR on cause-specific mortality was assessed using Cox proportional hazard models and cubic spline models.ResultsA baseline RHR of ≥ 90 beats per minute (bpm) was associated with higher all-cause mortality, as compared with an RHR of 60–70 bpm (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.17–2.19,P = 0.003), but not with cardiovascular (CV) mortality. A time-updated RHR of < 60 bpm (HR 1.41, 95% CI 1.07–1.85,P = 0.014) and a time-updated RHR of 70–80 bpm (HR 1.34, 95% CI 1.02–1.75,P = 0.036) were both associated with higher CV mortality as compared with an RHR of 60–70 bpm after multivariable adjustment. Analyses using cubic spline models confirmed that the association of time-updated RHR with all-cause and CV mortality complied with a U-shaped curve with 60 bpm as a reference.ConclusionIn this middle-aged male cohort, a time-updated RHR of 60–70 bpm was associated with the lowest CV mortality, suggesting that a time-updated RHR could be a useful long-term prognostic index in the general population.Graphic abstract
A risk-based groundwater modeling framework in coastal aquifers: a case study on Long Island, New York, USA
Authors: Karamouz Mohammad , Mahmoodzadeh Davood , Oude Essink Gualbert H. P. 
Published: July 2020

AbstractA methodology is proposed to define indices for quantifying risks under the threat of reducing in groundwater levels, the existence of saltwater intrusion (SWI), and an increasing nitrate contamination load in submarine groundwater discharge (SGD). The proposed methodology considers coastal regions under geological heterogeneity and it is tested on a groundwater system in Nassau County of Long Island, New York (USA). The numerical model is constructed with the SEAWAT code. The parameter uncertainty of this model is evaluated by coupling the Latin hypercube sampling method (as a sampling algorithm) and Monte Carlo simulation to consider the uncertainty in both hydraulic conductivity and recharge rate. The indices are presented in spatial maps that classify areas of risk to potential threats. The results show that two of the water districts have a high risk under conditions of decreasing groundwater level. Salinity occurs in the southern and southwestern parts of the Nassau County aquifer and a considerable area of high risk of SWI is identified. Furthermore, the average SGD rate with the associated fluxes of nitrate is estimated as 81.4 million m3/year (average 0.8 tons of nitrate through SGD per year), which can adversely affect the quality of life in the local coastal ecosystems. The framework developed in this study could help the water district managers to identify high-risk areas for short-term and long-term planning and is applicable to other coastal settings.
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement
Authors: Lee Hyeonyoul , Kim Heungdeok , Seo Jinwon , Choi Kyoungbaek , Lee Yunsin , Park Kiwon , Kim Sujeong , Mobasheri Ali , Choi Heonsik 
Published: July 2020

AbstractOsteoarthritis (OA) is the most common form of arthritis, characterized by cartilage destruction, pain and inflammation in the joints. Existing medications can provide relief from the symptoms, but their effects on the progression of the disease are limited. TissueGene-C (TG-C) is a novel cell and gene therapy for the treatment of OA, comprising a mixture of human allogeneic chondrocytes and irradiated cells engineered to overexpress transforming growth factor-β1 (TGF-β1). This study aims to investigate the efficacy and mechanism of action of TG-C in a rat model of OA. Using the monosodium-iodoacetate (MIA) model of OA, we examined whether TG-C could improve OA symptoms and cartilage structure in rats. Our results showed that TG-C provided pain relief and cartilage structural improvement in the MIA OA model over 56 days. In parallel with these long-term effects, cytokine profiles obtained on day 4 revealed increased expression of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the synovial lavage fluid. Moreover, the increased levels of TGF-β1 and IL-10 caused by TG-C induced the expression of arginase 1, a marker of M2 macrophages, and decreased the expression of CD86, a marker of M1 macrophages. These results suggest that TG-C exerts a beneficial effect on OA by inducing a M2 macrophage-dominant micro-environment. Cell therapy using TG-C may be a promising strategy for targeting the underlying pathogenic mechanisms of OA, reducing pain, improving function, and creating a pro-anabolic micro-environment. This environment supports cartilage structure regeneration and is worthy of further evaluation in future clinical trials.
From Sufficient Health to Sufficient Responsibility
Authors: Davies Ben , Savulescu Julian 
Published: July 2020

AbstractThe idea of using responsibility in the allocation of healthcare resources has been criticized for, among other things, too readily abandoning people who are responsible for being very badly off. One response to this problem is that while responsibility can play a role in resource allocation, it cannot do so if it will leave those who are responsible below a “sufficiency” threshold. This paper considers first whether a view can be both distinctively sufficientarian and allow responsibility to play a role even for those who will be left with very poor health. It then draws several further distinctions that may affect the application of responsibility at this level. We conclude that a more plausible version of the sufficientarian view is to allow a role for responsibility where failure to do so will leave someone else who is not responsible below the sufficiency threshold. However, we suggest that individuals must exhibit “sufficient responsibility” in order for this to apply, involving both a sufficient level of control and an avoidable failure to respond adequately to reasons for action.
Reversal of Long-Term Weight Regain After Roux-en-Y Gastric Bypass Using Liraglutide or Surgical Revision. A Prospective Study
Authors: Horber Fritz F. , Steffen Rudolf 
Published: July 2020

Abstract
Purpose
This study investigates whether pharmacotherapy with liraglutide is similarly effective in reversing weight regain more than 6 years after Roux-en-Y gastric bypass (RYGB) as revisional surgery aimed at restoring restriction.

Methods
Ninety-five consecutive patients (11 male, 84 female; mean BMI 45 ± 6 kg/m2) undergoing RYGB 9 ± 4 years ago were treated for 24 months as follows: Patients, who gained less than 10% from weight NADIR, served as controls and were provided lifestyle counseling (DC, n = 30). The others were allowed to choose between three different treatment groups: daily s.c. administration of liraglutide (LG, n = 34); endosurgery using Apollo’s Overstitch System™ (ES, n = 15), or implantation of a Fobi-ring with pouch resizing (FP, n = 16).

Results
Controls kept their weight stable during 24 months of study (− 0.1 ± 1.7 kg/m2). Weight loss was 4.8 ± 2.9 kg/m2 for LG and 5.5 ± 2.9 kg/m2 for FP, both losing more than 85% of regained weight from weight NADIR (p < 0.001). In contrast, weight loss in ES was 1.0 ± 0.9 kg/m2 (i.e., 20% of regained weight). Thirty-seven percent of FP experienced serious complications (p < 0.05) in contrast to the other groups. An improved prevalence of hypertension and dyslipidemia was observed in LG and FP (p < 0.02) 24 months after intervention.

Conclusions
Weight regain during more than 6 years after RYGB can be safely and effectively reversed with liraglutide. Compared with revisional surgery, pharmacotherapy with liraglutide was low risk and resulted in an important improvement in hypertension and dyslipidemia. Therefore, daily subcutaneous injections of liraglutide are a valid option to treat weight regain after RYGB.
Efficiently and Effectively Recognizing Toricity of Steady State Varieties
Authors: Grigoriev Dima , Iosif Alexandru , Rahkooy Hamid , Sturm Thomas , Weber Andreas 
Published: July 2020

AbstractWe consider the problem of testing whether the points in a complex or real variety with non-zero coordinates form a multiplicative group or, more generally, a coset of a multiplicative group. For the coset case, we study the notion of shifted toric varieties which generalizes the notion of toric varieties. This requires a geometric view on the varieties rather than an algebraic view on the ideals. We present algorithms and computations on 129 models from the BioModels repository testing for group and coset structures over both the complex numbers and the real numbers. Our methods over the complex numbers are based on Gröbner basis techniques and binomiality tests. Over the real numbers we use first-order characterizations and employ real quantifier elimination. In combination with suitable prime decompositions and restrictions to subspaces it turns out that almost all models show coset structure. Beyond our practical computations, we give upper bounds on the asymptotic worst-case complexity of the corresponding problems by proposing single exponential algorithms that test complex or real varieties for toricity or shifted toricity. In the positive case, these algorithms produce generating binomials. In addition, we propose an asymptotically fast algorithm for testing membership in a binomial variety over the algebraic closure of the rational numbers.
Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells
Authors: Janowska Justyna , Gargas Justyna , Ziemka-Nalecz Malgorzata , Zalewska Teresa , Sypecka Joanna 
Published: July 2020

AbstractDifferentiation of oligodendrocyte progenitors towards myelinating cells is influenced by a plethora of exogenous instructive signals. Insulin-like growth factor 1 (IGF-1) is one of the major factors regulating cell survival, proliferation, and maturation. Recently, there is an ever growing recognition concerning the role of autocrine/paracrine IGF-1 signaling in brain development and metabolism. Since oligodendrocyte functioning is altered after the neonatal hypoxic-ischemic (HI) insult, a question arises if the injury exerts any influence on the IGF-1 secreted by neural cells and how possibly the change in IGF-1 concentration affects oligodendrocyte growth. To quantify the secretory activity of neonatal glial cells, the step-wise approach by sequentially using the in vivo, ex vivo, and in vitro models of perinatal asphyxia was applied. A comparison of the results of in vivo and ex vivo studies allowed evaluating the role of autocrine/paracrine IGF-1 signaling. Accordingly, astroglia were indicated to be the main local source of IGF-1 in the developing brain, and the factor secretion was shown to be significantly upregulated during the first 24 h after the hypoxic-ischemic insult. And conversely, the IGF-1 amounts released by oligodendrocytes and microglia significantly decreased. A morphometric examination of oligodendrocyte differentiation by means of the Sholl analysis showed that the treatment with low IGF-1 doses markedly improved the branching of oligodendroglial cell processes and, in this way, promoted their differentiation. The changes in the IGF-1 amounts in the nervous tissue after HI might contribute to the resulting white matter disorders, observed in newborn children who experienced perinatal asphyxia. Pharmacological modulation of IGF-1 secretion by neural cells could be reasonable solution in studies aimed at searching for therapies alleviating the consequences of perinatal asphyxia.
1H, 13C and 15N resonance assignments for the microtubule-binding domain of the kinetoplastid kinetochore protein KKT4 from Trypanosoma brucei
Authors: Ludzia Patryk , Akiyoshi Bungo , Redfield Christina 
Published: July 2020

AbstractKKT4 is a kinetoplastid-specific microtubule-binding kinetochore protein that lacks significant similarity to any known kinetochore or microtubule-binding proteins. Here we present the 1H, 13C and 15N resonance assignments for several fragments from the microtubule-binding domain of KKT4 (KKT4115–343) from Trypanosoma brucei. These assignments provide the starting point for detailed investigations of the structure, dynamics and interactions of the microtubule-binding region of KKT4.
Psychophysical comparison of the auditory and tactile perception: a survey
Authors: Merchel Sebastian , Altinsoy M. Ercan 
Published: July 2020

AbstractIn this paper, the psychophysical abilities and limitations of the auditory and vibrotactile modality will be discussed. A direct comparison reveals similarities and differences. The knowledge of those is the basis for the design of perceptually optimized auditory-tactile human–machine interfaces or multimodal music applications. Literature data and own results for psychophysical characteristics are summarized. An overview of the absolute perception thresholds of both modalities is given. The main factors which influence these thresholds are discussed: age, energy integration, masking and adaptation. Subsequently, the differential sensitivity (discrimination of intensity, frequency, temporal aspects and location) for suprathreshold signals is compared.
Growth, fatty, and amino acid profiles of the soil alga Vischeria sp. E71.10 (Eustigmatophyceae) under different cultivation conditions
Authors: Remias Daniel , Nicoletti Cecilia , Krennhuber Klaus , Möderndorfer Bettina , Nedbalová Linda , Procházková Lenka 
Published: July 2020

AbstractIn this study, a unicellular soil alga isolated from farmland in Germany was surveyed. The investigation of the hypervariable molecular markers ITS1 rDNA and ITS2 rDNA identified strain E71.10 as conspecific with Vischeria sp. SAG 51.91 (Eustigmatophyceae). The culture was tested for biomass generation and for the yield of fatty acids and amino acids. The survey included four different culture conditions (conventional, elevated CO2, nitrogen depletion, or sodium chloride stress) at room temperature. The best yield of dry biomass was achieved applying 1% CO2, whereas nitrogen-free medium resulted into least growth. The fatty acid content peaked in nitrogen-free medium at 59% per dry mass. Eicosapentaenoic acid was the most abundant fatty acid in all treatments (except for nitrogen free), accounting for 10.44 to 16.72 g/100 g dry mass. The highest content of amino acids (20%) was achieved under conventional conditions. The results show that abiotic factors strongly influence to which extent metabolites are intracellularly stored and they confirm also for this yet undescribed strain of Vischeria that Eustigmatophyceae are promising candidates for biotechnology.
Delineation of Average 1-D Shear Velocity Structure below North India by Surface Wave Dispersion Study
Authors: Gupta Abhishek Kumar , Mandal Prantik 
Published: July 2020

Abstract
During 2014-16, a semi-permanent network of four 3-component broadband seismographs was operational in the Rajasthan craton and Aravalli mobile belt in the NW Indian shield. The reliable and accurate broadband data from 16 selected regional Indian earthquakes of Mw5.5-7.8 from this seismic network enabled to estimate the group velocity dispersion characteristics and one-dimensional regional shear velocity structure of northern India, covering the region below north India between the entire Himalaya (from the Pakistan Himalaya in west to the Burmese arc in the east) and Rajasthan (including Aravalli mobile belt). First, Rayleigh- (at 7-87s) and Love- (at 7-82s) wave group velocity dispersion curves were measured and then these curves were inverted to estimate the crustal and upper mantle structure below north India. It is observed that group velocities are of variable nature within the region. This could be attributed to the complex crust-mantle structure in the study region resulted from the magmatism episodes associated with the Proterozoic collision, 65 Ma Deccan volcanism and the Himalayan collision. The best model in the study region reveals a two-layered crust, with a 15-km thick upper-crust (UC) of average shear velocity (Vs) of 3.12 km/s and a 25-km thick lower-crust(LC) of average Vs of 3.44 km/sec. The modeling detects a drop in Vs (~1-2%) at 79-120 km depths, underlying north India, representing the probable seismic lithosphere-asthenosphere boundary (LAB) at 79 km depth. A geothermal gradient extrapolated from the surface heat flow (~74 mW/m2) shows that such a gradient would intercept CO2-bearing mantle peridotite solidus at 100 km depth, and thus could signal the presence of small amounts of partially melted magma below 100 km depth. Therefore, this 1-2% drop in Vs could be attributed to the presence of carbonatite melts in the upper mantle related to magmatic episode of 65 Ma Deccan plume activity as also suggested by existing geological and seismological evidence.