bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of PEKK oligomers sizing on the dynamic mechanical behavior of poly(ether ketone ketone)/carbon fiber composites
Authors: Alexandre Mike Abidine , Dantras Eric , Lacabanne Colette , Perez Emile , Franceschi Sophie , Coudeyre Damien 
Published: December 2019

ABSTRACTPoly(ether ketone ketone) (PEKK)/unidirectional carbon fiber (CF) composites have a poor interface. Accordingly, PEKK oligomer (PEKKo) sizing with a chemical compatibility with PEKK is proposed for promoting interfacial interactions in order to enhance mechanical performances. The thermal stability until 500 °C has been shown by thermogravimetric analysis (TGA). In order to compare static and dynamic sizing methods, “lab sizing” and “pilot sizing” were carried out. Scanning electron microscopy images of freeze fractures of PEKK/unsized CF, PEKK/PEKKo lab‐sized CF and PEKK/PEKKo pilot‐sized CF show that the PEKKo sizing causes an improvement of fiber/PEKK interactions, regardless of the sizing method. Indeed, in both cases, there is a continuity of matter at the interface while we observe a poor wetting of CF by matrix in PEKK/unsized CF. Dynamic mechanical relaxations in shear were analyzed as a function of temperature. The increase of storage modulus upon sizing is observed for both methods but it is more important for PEKKo pilot sizing. In the same way, the mechanical energy loss increases, it reflects the optimization of stress transfer between matrix and fibers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48818.
Randomized clinical trial of intracorporeal versus extracorporeal anastomosis in laparoscopic right colectomy (IEA trial)
Authors: Bollo J , Turrado V , Rabal A , Carrillo E , Gich I , Martinez M C , Hernandez P , Targarona E 
Published: December 2019

Abstract

Background
Several non-randomized and retrospective studies have suggested that intracorporeal anastomosis (IA) has advantages over extracorporeal anastomosis (EA) in laparoscopic right colectomy, but scientific evidence is lacking. The aim was to compare short-term outcomes and to define the possible benefits of IA compared with EA in elective laparoscopic right colectomy.

Methods
An RCT was conducted from May 2015 to June 2018. The primary endpoint was duration of hospital stay. Secondary endpoints were intraoperative technical events and postoperative clinical outcomes.

Results
A total of 140 patients were randomized. Duration of surgery was longer for procedures with an IA than in those with an EA (median 149 (range 95–215) versus 123 (60–240) min; P &lt; 0·001). Wound length was shorter in the IA group (median 6·7 (4–9·5) versus 8·7 (5–13) cm; P &lt; 0·001). Digestive function recovered earlier in patients with an IA (median 2·3 versus 3·3 days; P = 0·003) and the incidence of paralytic ileus was lower (13 versus 30 per cent; P = 0·022). Less postoperative analgesia was needed in the IA group (mean(s.d.) weighted analgesia requirement 39(24) versus 53(26); P = 0·001) and the pain score was also lower (P = 0·035). The postoperative decrease in haemoglobin level was smaller (mean(s.d.) 8·8(1·7) versus 17·1(1·7) mg/dl; P = 0·001) and there was less lower gastrointestinal bleeding (3 versus 14 per cent; P = 0·031) in the IA group. IA was associated with a significantly better rate of grade I and II complications (P = 0·016 and P = 0·037 respectively). The duration of hospital stay was slightly shorter in the IA group (median 5·7 (range 2–19) versus 6·6 (2–23) days; P = 0·194).

Conclusion
Duration of hospital stay was similar, but IA was associated with less pain and fewer complications. Registration number: NCT02667860 (http://www.clinicaltrials.gov).
Two‐step modification of silica for efficient adsorption of phosphatidylcholine in water and application in phospholipase D‐catalyzed transphosphatidylation
Authors: Wang Jiao , Yu Wenyu , Zhang Xiaoli , Zhang Tiantian , Wang Huan , Shu Wenfang , Liu Li , Zhao Binxia , Li Binglin 
Published: December 2019

AbstractAn efficient and green aqueous–solid system was introduced for phospholipase D‐mediated transphosphatidylation. γ‐(2,3‐epoxypropoxy) propytrimethoxysilane was covalently bound to silica and esterified by acetic acid, which acted as an anchor molecule to facilitate the adsorption of phosphatidylcholine (PC) in aqueous solutions. Obtained silica‐adsorbed PC was successfully used for transphosphatidylation to produce phosphatidylserine (PS). The PC loading and PS yield reached 98.8 and 98.3%, respectively. A new model was proposed to illustrate the adsorption and enzymatic processes. Moreover, this aqueous–solid system provides a promising way for the continuous production. Four kinds of phospholipids were biosynthesized in the pack‐bed reactor. The stability of the aqueous–solid system was excellent, as demonstrated by its use 30 times without any loss of the productivity. The product was eluted by coconut oil and manufactured into microcapsules. Toxic agents were completely avoided in the whole production process.
A novel model to predict cancer‐specific survival in patients with early‐stage uterine papillary serous carcinoma (UPSC)
Authors: Chen Lihua , Liu Xiaona , Li Mengjiao , Wang Shuoer , Zhou Hongyu , Liu Lei , Cheng Xi 
Published: December 2019

AbstractObjectiveStage I‐II uterine papillary serous carcinoma (UPSC) has aggressive biological behavior and leads to poor prognosis. However, clinicopathologic risk factors to predict cancer‐specific survival of patients with stage I‐II UPSC were still unclear. This study was undertaken to develop a prediction model of survival in patients with early‐stage UPSC.MethodsUsing Surveillance, Epidemiology, and End Results (SEER) database, 964 patients were identified with International Federation of Gynecology and Obstetrics (FIGO) stage I‐II UPSC who underwent at least hysterectomy between 2004 and 2015. By considering competing risk events for survival outcomes, we used proportional subdistribution hazards regression to compare cancer‐specific death (CSD) for all patients. Based on the results of univariate and multivariate analysis, the variables were selected to construct a predictive model; and the prediction results of the model were visualized using a nomogram to predict the cancer‐specific survival and the response to adjuvant chemotherapy and radiotherapy of stage I‐II UPSC patients.ResultsThe median age of the cohort was 67 years. One hundred and sixty five patients (17.1%) died of UPSC (CSD), while 8.6% of the patients died from other causes (non‐CSD). On multivariate analysis, age ≥ 67 (HR = 1.45, P = .021), tumor size ≥ 2 cm (HR = 1.81, P = .014) and >10 regional nodes removed (HR = 0.52, P = .002) were significantly associated with cumulative incidence of CSD. In the age ≥67 cohort, FIGO stage IB‐II was a risk factor for CSD (HR = 1.83, P = .036), and >10 lymph nodes removed was a protective factor (HR = 0.50, P = .01). Both adjuvant chemotherapy combined with radiotherapy and adjuvant chemotherapy alone decreased CSD of patients with stage I‐II UPSC older than 67 years (HR = 0.47, P = .022; HR = 0.52, P = .024, respectively). The prediction model had great risk stratification ability as the high‐risk group had higher cumulative incidence of CSD than the low‐risk group (P < .001). In the high‐risk group, patients with post‐operative adjuvant chemoradiotherapy had improved CSD compared with patients who did not receive radiotherapy nor chemotherapy (P = .037). However, there was no such benefit in the low‐risk group.ConclusionOur prediction model of CSD based on proportional subdistribution hazards regression showed a good performance in predicting the cancer‐specific survival of early‐stage UPSC patients and contributed to guide clinical treatment decision, helping oncologists and patients with early‐stage UPSC to decide whether to choose adjuvant therapy or not.
Successful Management of Peri‐Implantitis Using a Titanium Brush and a Doxycycline‐Saline Slurry for Surface Detoxification With Guided Bone Regeneration: A 5‐Year Follow‐Up
Authors: Neely Anthony L. , Thompson Tamika N. , Gupta Vidushi , Kinaia Bassam 
Published: December 2019

IntroductionThe inflammation associated with peri‐implantitis lesions can be difficult to manage and regeneration of lost bone is unpredictable. Unfortunately, opinions vary on the best method(s) for elimination of inflammation and restoration of residual osseous defects. This report describes the successful surgical management of a peri‐implantitis lesion with reduction of inflammation and maintenance of nearly completely regenerated horizontal and vertical bone over 5 years.Case PresentationA 55‐year‐old healthy, non‐smoking, African‐American female presented in 2013 with inflammation and >25% bone loss at implant site #18. Probing depths ranged from 6 to 13 mm with bleeding on probing (BOP). She was diagnosed with peri‐implantitis. She reported a history of routine scaling every 6 months since implant and crown placement 3 years earlier (2010). Initial periodontal treatment consisted of non‐surgical scaling and implant debridement. Deep pockets and BOP persisted at re‐evaluation. Surgical treatment consisted of full thickness flap, soft tissue curettage with titanium curets, and detoxification of the implant surface with a doxycycline and sterile saline slurry using a titanium brush. Mineralized freeze‐dried bone allograft and demineralized freeze‐dried bone allograft in a 50:50 ratio was placed and covered with a resorbable collagen membrane. All postoperative visits were uneventful. Maximum probing depths around the treated implant at the 5+‐year follow‐up (2019) were 4 mm with no BOP and nearly complete bone fill.ConclusionsThis case illustrates that it is possible to successfully eliminate clinical inflammation associated with peri‐implantitis, regenerate bone, and maintain health for >5 years.
Coculturing of Mosquito‐Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis
Authors: Ganley Jack G. , D'Ambrosio Hannah K. , Shieh Meg , Derbyshire Emily R. 
Published: December 2019

AbstractAnopheles mosquito microbiomes are intriguing ecological niches. Within the gut, microbes adapt to oxidative stress due to heme and iron after blood meals. Although metagenomic sequencing has illuminated spatial and temporal fluxes of microbiome populations, limited data exist on microbial growth dynamics. Here, we analyze growth interactions between a dominant microbiome species, Elizabethkingia anophelis, and other Anopheles‐associated bacteria. We find E. anophelis inhibits a Pseudomonas sp. via an antimicrobial‐independent mechanism and observe biliverdins, heme degradation products, upregulated in cocultures. Purification and characterization of E. anophelis HemS demonstrates heme degradation, and we observe hemS expression is upregulated when cocultured with Pseudomonas sp. This study reveals a competitive microbial interaction between mosquito‐associated bacteria and characterizes the stimulation of heme degradation in E. anophelis when grown with Pseudomonas sp.
An unusual cause of multiple incidental lung nodules
Authors: Sala Michiel L. , von der Thusen Jan H. , Korteweg Christine , Quarles van Ufford Henriëtte M. E. 
Published: December 2019

AbstractCystic or cavitating lung nodules may reflect an additional diagnostic challenge in benign metastasizing leiomyoma. Our case underlines the importance of combining clinical and radiological findings with specific pulmonary pathology consultation.
A Boron‐Doped Diamond Anode for the Electrochemical Removal of Parabens in Low‐Conductive Solution: From a Conventional Flow Cell to a Solid Polymer Electrolyte System
Authors: Abidi Jihen , Samet Youssef , Panizza Marco , Martinez‐Huitle Carlos A. , Carpanese M. Paola , Clematis Davide 
Published: December 2019

AbstractSolution conductivity plays a fundamental role for the employment of electrochemical advanced oxidation processes (EAOPs) and in the determination of their energy consumption. In this paper, a conventional flow cell based on a boron‐doped diamond (BDD) anode that requires the addition of supporting electrolyte, is compared with a cell setup based on solid polymer electrolyte (SPE). The new cell configuration avoids the addition of salt to increase solution conductivity. The performances of the two systems are compared for the treatment of different solutions containing methylparaben, ethylparaben and propylparaben. Both systems are able to remove all the three parabens, but the SPE‐system provided a better performance, with a maximum COD removal of 91 % and energy consumption of 16.25 kWh m−3, whereas the conventional system can remove a maximum of 81 % consuming 10.92 kWh m−3. The influences of parameters such as current density, flow conditions and supporting electrolyte concentration were analyzed, and results confirm that the SPE system is a promising system to treat low‐conductive solutions polluted by parabens.
A Comprehensive Study on Tetraaryltetrabenzoporphyrins
Authors: Ruppel Michael , Lungerich Dominik , Sturm Sabrina , Lippert Rainer , Hampel Frank , Jux Norbert 
Published: December 2019

AbstractTetraaryltetrabenzoporphyrins (TATBPs) show, due to their optoelectronic properties, rising potential as dyes in various fields of physical and biomedical sciences. However, unlike in the case of porphyrins, the potential structural diversity of TATBPs has been explored only to little extent, owed mainly to synthetic hurdles. Herein, we prepared a comprehensive library of 30 TATBPs and investigated their fundamental properties. We elucidated structural properties by X‐ray crystallography and found explanations for physical properties such as solubility. Fundamental electronic aspects were studied by optical spectroscopy as well as by electrochemistry and brought in context to the stability of the molecules. Finally, we were able to develop a universal synthetic protocol, utilizing a readily established isoindole synthon, which gives TATBPs in high yields, regardless of the nature of the used arylaldehyde and without meticulous chromatographic purifications steps. This work serves as point of orientation for scientists, that aim to utilize these molecules in materials, nanotechnological, and biomedical applications.
A Triazine‐Based Analogue of Graphyne: Scalable Synthesis and Applications in Photocatalytic Dye Degradation and Bacterial Inactivation
Authors: Chen Tao , Li Wen‐Qian , Chen Xiao‐Jia , Guo Yun‐Zhe , Hu Wei‐Bo , Hu Wen‐Jing , Liu Yahu A. , Yang Hui , Wen Ke 
Published: December 2019

AbstractGraphyne, a theorized carbon allotrope possessing only sp‐ and sp2‐hybridized carbon atoms, holds great potentials in many fields, especially in catalysis and energy‐transfer/storage devices. Using a bottom‐up strategy, we synthesized a new N‐doped graphyne analogue, triazine‐ and 1,4‐diethynylbenzene‐based graphyne TA‐BGY, in solution in gram‐scale. The unique sp/sp2 carbon‐conjugated TA‐BGY possesses an extended porous network structure with a BET surface area of approximately 300 m2 g−1. Owing to its low optical band gap (1.44 eV), TA‐BGY was expected to have many applications, which were exemplified by the photodegradation of methyl orange and photocatalytic bacterial inactivation.
New‐onset persistent opioid use following breast cancer treatment in older adult women
Authors: Roberts Andrew W. , Fergestrom Nicole , Neuner Joan M. , Winn Aaron N. 
Published: December 2019

BackgroundPatients with cancer‐related pain are underrepresented in the opioid literature despite high opioid exposure and numerous risk factors for adverse opioid outcomes, including unnecessary persistent opioid use. The objective of this study was to determine the extent, historical trends, and predictors of new‐onset persistent opioid use among older adult women after active breast cancer treatment.MethodsUsing Surveillance, Epidemiology, and End Results–Medicare data for opioid‐naive women diagnosed with stage 0 to III breast cancer at the age of 66 to 90 years between 2008 and 2013, this study estimated overall and quarterly adjusted probabilities of new‐onset persistent opioid use, which was defined as receiving ≥90 days' supply of opioids in the year after active breast cancer treatment. Sensitivity analyses were conducted with an alternative definition of persistent opioid use: any opioid fill 90 to 180 days after active cancer treatment.ResultsNearly two‐thirds of the subjects received prescription opioid therapy during cancer treatment. Quarterly probabilities of new‐onset persistent opioid use after active treatment ranged from 2% to 4%; in sensitivity analyses, the alternative outcome definition resulted in predicted probabilities ranging from 11.4% to 14.7%. Subjects with more advanced disease, a higher comorbidity burden, a low‐income status, and greater opioid exposure during active cancer treatment were more likely to develop persistent opioid use.ConclusionsPersistent opioid use was an infrequent occurrence among older adult patients with breast cancer completing cancer treatment between 2008 and 2013. This finding was encouraging because of the concerning opioid trends seen in noncancer populations. However, opportunities to further mitigate unsafe opioid use as a complication of cancer care, including standardization of persistent opioid use definitions, should be explored.
In‐Liquid Plasma Synthesis of Nanographene with a Mixture of Methanol and 1‐Butanol
Authors: Ando Atsushi , Ishikawa Kenji , Takeda Keigo , Ohta Takayuki , Ito Masafumi , Hiramatsu Mineo , Kondo Hiroki , Sekine Makoto , Hori Masaru 
Published: December 2019

AbstractNanometer‐size graphene sheets (nanographene) were synthesized by the in‐liquid plasma method employing a mixture of alcohols. Pure methanol in‐liquid plasma was found to not synthesize any nanographene. Pure ethanol synthesized nanographene with high crystallinity. Highly crystalline nanographene with a narrow full width‐half maximum of the Raman scattering G‐band (FWHMG) was obtained by mixing 1‐butanol with methanol. This is due to the formation of carbon ring structures being inhibited by the addition of methanol. The ratio of added methanol determined the nanographene crystallinity and yield under a trade‐off relationship, allowing the crystallinity and nanographene yield to be controlled by controlling the ratio. Gas chromatography‐mass spectrometric analysis of by‐products in the liquids’ supernatant showed that the crystallinity of the synthesized nanographene correlated with the ratio of carbon over oxygen of the alcohol precursors (C/O), i. e., the amount of hydroxyl groups in the liquids, and hence controlling the C/O ratio can be used to control the graphene crystallinity in the in‐liquid plasma synthesis.
Visible‐Light‐Driven Thiol‐yne Reaction: A Practical Synthesis of (1,2‐diarylvinyl)(aryl/alkyl)sulfides
Authors: Chatterjee Anamitra , König Burkhard , Natarajan Palani 
Published: December 2019

AbstractA mild, efficient and straightforward visible‐light‐driven method has been developed to construct 1,2‐diarylvinyl sulfides under catalyst‐ and additive‐free conditions. The formation of small amounts of thiyl radicals under visible light irradiation allows the synthesis of 1,2‐diarylvinyl sulfides in good yield with an excellent functional group tolerance.
Primary effusion lymphoma in human immune deficiency (HIV)‐negative non‐organ transplant immunocompetent patients
Authors: Yuan Lisi , Cook James R. , Elsheikh Tarik M. 
Published: December 2019

AbstractPrimary effusion lymphoma (PEL) is a rare non‐Hodgkin's lymphoma most commonly occurring in the context of human immune deficiency (HIV) infection. Herpes virus 8 (HHV‐8) has been associated with PEL and considered to be the etiologic agent. In addition, most cases (60%‐90%) also show evidence of Epstein‐Barr virus (EBV) infection. We describe here an elderly man who was HIV seronegative and immunocompetent, and presented with worsening weakness and ascites. The diagnosis of PEL was rendered cytologically and supported by the results of flow cytometry. The presence of HHV‐8 was demonstrated by immunohistochemistry, whereas EBV‐associated genetic material was absent by EBER ISH. No lymphadenopathy or organ involvement with lymphoma was found. Systemic chemotherapy with lenalidomide was started given the poor prognosis and commodities of severe coronary artery disease; however, the patient did not respond and succumbed to his disease in 4 months. We present detailed cytologic and clinical findings of this very rare occurrence, and review literature of all reported PEL cases of HIV‐negative, nontransplant, immunocompetent patients.
State of the art design protocol for custom made footwear for people with diabetes and peripheral neuropathy
Authors: Bus Sicco A. , Zwaferink Jennefer B. , Dahmen Rutger , Busch‐Westbroek Tessa 
Published: December 2019

AbstractSupported by evidence‐based guidelines, custom‐made footwear is often prescribed to people with diabetes who are at risk for ulceration. However, these guidelines do not specify the footwear design features, despite available scientific evidence for these features. We aimed to develop a design protocol to support custom‐made footwear prescription for people with diabetes and peripheral neuropathy. The population of interest was people with diabetes who are at moderate‐to‐high risk of developing a foot ulcer, for whom custom‐made footwear (shoes and/or insoles) can be prescribed. A group of experts from rehabilitation medicine, orthopaedic shoe technology (pedorthics) and diabetic foot research, reviewed the scientific literature and met during 12 face‐to‐face meetings to develop a footwear design algorithm and evidence‐based pressure‐relief algorithm as parts of the protocol. Consensus was reached where evidence was not available. Fourteen domains of foot pathology in combination with loss of protective sensation were specified for the footwear design algorithm and for each domain shoe‐specific and insole (orthosis)‐specific features were defined. Most insole‐related features and some shoe‐related features were evidence based, whereas most shoe‐related features were consensus based. The pressure‐relief algorithm was evidence based using recent footwear trial data and specifically targeted patients with a healed plantar foot ulcer. These footwear design and pressure‐relief algorithms are the first of their kind and should facilitate more uniform decision making in the prescription and manufacturing of adequate shoes for moderate‐to‐high‐risk patients, reducing variation in footwear provision and improving clinical outcome in the prevention of diabetic foot ulcers.