bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Drug Utilization of Antibiotics in Respiratory Tract Infections among Geriartrics
Authors: Charave Sripuram , Suresh Reshmi , Shihab , , Fayiz Mohammed , Dev Apoorva 
Published: June 2020

Back ground: Respiratory Tract Infections (RTIs) often pose a major threat for geriatric patients (>60 years) who are at higher risk of developing complications. The first line treatments for RTIs are antibiotics which help in reducing the infection. As there is increasing incidence of antimicrobial resistance it is necessary to conduct drug utilization of antibiotics which helps in better understanding about errors and risks involved in prescriptions.
Objectives: The objective of the study is to access the prescribing pattern, appropriate use of antibiotics and inappropriateness of antibiotics in viral infections.
Methodology: The present study is a prospective observational study. The study included 110 patients which included the evaluation of the patients medical records of antibiotics, sputum culture reports and physician records.
Results: Out of 110 geriartric RTI patients, female (59.09%) were more predominantly affected over males (40.90%). Among the RTIs diagnosed pneumonia (40%) was higher followed by LRTI (28.18%). The common signs and symptoms found were breathlessness (34.54%) with major comorbidity of diabetes milletus (47.31%). Piperacillin + tazobactam (40.90%) was the mostly prescribed antibiotic for both gram positive (Streptococci) and gram negative (E. coli) bacteria which was given through I.V. (90%). Total drug interactions and medication errors were 13.03% and 3.32% respectively.
Conclusion: The present study gives an overview of antibiotics use and complications involved in geriatric population diagnosed with RTIs. Appropriate antibiotic usage according to Hospital Antibiotic Policy was observed in the study site with lower number of medication errors and drug interactions.
Key words: Respiratory Tract Infections, drug utilization, antibiotics, geriatrics.
Development and Evaluation of Gastro-retentive Floating Tablet of Rilpivirine Hydrochloride for the Treatment of HIV
Authors: Trivedi Dipali , Majumdar Arti , Malviya Neelesh 
Published: June 2020

Besides enormous improvements in drug delivery, oral route has been highly and effectively utilized route of administration. Floating drug delivery that is also known to be low density system is advancement in the class of gastro-retentive drug delivery system. In the present research work, floating drug delivery of Rilpivirine hydrochloride was developed by overcoming various limitations and troubles associated with the drug including poor absorption in intestinal pH and degradation when comes in contact with higher pH environment. [2] Prepared formulations were evaluated for various parameters like friability, hardness, thickness, drug content analysis, floating properties and in-vitro drug release study. Based on the evaluation, concluded that floating drug delivery system is a non-toxic as well as cost-effective technique for the rationale of enhancing bioavailability and absorption of poorly water soluble drugs. The improvement in gastric residence time is a clear sign. It can be able to use in the future for more acidic soluble drugs to enhance solubility and absorption.
Keywords: Floating drug delivery, gastric residence time, Rilpivirine, effervescent, NNRTI.
A Case Report on Viral Meningoencephalitis with Radiculoneuropathy
Authors: Ali Salman Mir , Faizan Abdullah Md , Baleeqhuddin Mohammed 
Published: June 2020

Meningoencephalitis is an inflammation of brain and its surrounding membranes. It can be caused by bacteria, viruses, fungi, protozoa and by various other etiology. Radiculoneuropathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or more nerves are affected. The classic triad of fever, stiff neck and altered sensorium are seen in <50% of all patients with meningitis. Clinical presentation of viral encephalitis includes a prodrome of fever, headache, myalgia, and mild respiratory infection. Altered mentation, focal neurological deficits and seizures usually follow. Patient was brought to emergency department of hospital. He provided with empirical anti-biotic therapy and supportive care. Laboratory investigation like CSF analysis, liver function test, renal function test. Blood test like complete blood picture, dengue Ag. Microbiological test was also carried out. Radiological imaging like MRI of Brain, MRI of spine, Chest X-Ray. Upon clinical diagnosis patient was provided with antibiotic, antiviral and supportive care. Patient was also provided with mechanical ventilator. He was treated for 14 days.
Keywords: meningoencephalitis, CSF analysis, classical triad.
Vaccine Preperative Trial for Leptospirosis and their Pathological, Immunological Study by Serum Electrophoresis
Authors: MANAM VISHNU KIRAN , Sumathi G 
Published: June 2020

Leptospirosis is a fatal infectious disease caused by different serovars of Leptospira spirochetes affecting humans and animals. In the present study, the trials of the whole-cell killed formalin treated monovalent vaccine using Leptospira icterohaemorrhagiae and trivalent vaccine using Leptospira icterohaemorrhagiae, Leptospira louisiana, and Leptospira hebdomadis were studied. The serum electrophoresis studies were done after administration of the vaccine into the experimental albino mice along with the booster dose of the vaccinated serum by densitometric readings. Similarly, the pathological observations were made by dissecting the virulent mice, vaccinated mice, and comparing them with the control mice. The MAT titre was also studied after the booster dose administration of the vaccinated serum. The monovalent and trivalent whole-cell killed formalin treated vaccines shows significant raise in the total proteins, albumin, globulin, α 1 globulin, α 2 globulin, β globulin and γ globulins of the serum as well as increase in significant levels in the antibody levels after the administration of the booster dose at an interval of 14 days.
Keywords: Leptospira, Whole-cell killed formalin treated vaccine, Immunological study, Pathological study, Serum electrophoresis.
Indo-Iranian borrowings in Uralic (tulossa)
Authors: Holopainen Sampsa 
Published: June 2020

Sampsa Holopaisen suomalais-ugrilaisen kielentutkimukseen alaan kuuluva väitöskirja tarkastettiin Helsingin ylipistossa lauantaina 14. joulukuuta 2019. Vastaväittäjänä toimi professori Matin Kümmel Jenan yliopistosta ja kustoksena professori Janne Saarikivi.
Sampsa Holopainen: Indo-Iranian borrowings in Uralic: critical overview of sound-substitutions and distribution criterion. Helsinki: Helsingin yliopisto 2019. Kirja on luettavissa osoitteessa http://urn.fi/URN:ISBN:978-951-51-5729-4
Regenerasi Fungsi x<sup>2</sup>-9x-99 Dalam Pembangkit Bilangan Acak Berbasis CSRPNG Chaos
Authors: Lihananto David , Wowor Alz Danny 
Published: June 2020

This study examines whether the function f(x)=x2-9x-99 can be used as a key generator in cryptography. The quadratic function is regenerated using the fixed point iteration method into an iteration function. The distribution of digits to the output of iterative function to generate a number of chaos. Randomization testing uses run test and monobit testing. Followed by cryptographic testing to get the correlation between ciphertext and key which will be used as a decision whether the resulting key is random or not. Based on research that has been done iteration function xi = (xi-12-9xi-1-99)/9 can generate CSRPNG Chaos random numbers with the correlation level closest to the value of 0.
WHERE ARE THEY NOW? UNDERSTANDING CAREER PERSISTENCE OF WOMEN IN ENGINEERING PRACTICE IN MANITOBA
Authors: Atamanchuk Kathryn , Friesen Marcia 
Published: June 2020

Women are underrepresented in the Canadian engineering profession at a rate of nearly 10:1 when compared to their male counterparts. This poses a problem for a profession whose goal is to provide innovative and inclusive solutions that work for all people. In Manitoba, while women are underrepresented in engineering at the same rate as the national average, there is also evidence that some either never enter the profession after graduation, or leave at various stages in their career. While there is significant literature to examine recruitment to and retention of women to engineering study at colleges and universities, there is much less research on women’s persistence in engineering practice post-graduation. Accordingly, this study was designed to address the research question: What are the elements of women’s experiences in the engineering profession that both enable and deter their persistence in the profession, and how do these elements or factors interact with one another over time & space? The findings generally align with the literature-based conceptual framework and indicate that this is a multi-dimensional problem that includes factors such as a need for improved work-life balance, workplace cultural shifts, and confidence building. Implications of these finding include a need to support both new graduates in the licensure process and former members who wish to return to practice. Concrete proposals to ease re-entry to practice are also presented.
WHAT IS ENGINEERING SCIENCE? DEFINING A DISCIPLINE THROUGH A CROSS-INSTITUTIONAL COMPARISON AND A MULTI-INSTITUTIONAL WORKSHOP
Authors: Romkey Lisa , Dawe Nikita , Khan Rubaina 
Published: June 2020

The Division of Engineering Science at the University of Toronto offers a complex, multidisciplinary undergraduate program, commonly known as "EngSci”. We are in the first of a multi-year project titled ROLE (Realigning Outcomes with Learning Experiences), designed to proactively realign curriculum, pedagogy, students, and brand with our program goals. The first step in this process is to understand the state of Engineering Science as an academic discipline more broadly, and to better understand its role in the broader engineering and science landscape. To better understand the discipline, we have used the academic plan model to compare eight engineering science programs from around the globe. The academic plan model supports the identification of internal and external factors that shape academic programs and frames the academic plan itself as seven related components that make up curriculum. Utilizing public-facing documentation such as websites and grey literature, we compared the IESC (International Engineering Science Consortium) programs and found differences in fundamental curriculum content, sub-disciplinary foci, organizational structure, and sources of external influence. Concurrently, we conducted a workshop with members from the IESC to facilitate dialogue on the state of the discipline. This workshop resulted in a number of interesting artifacts, documenting the perspective of the participants. Some key themes that emerged included a strong focus on fundamentals and first principles; a focus on non-traditional and rapidly developing sub-disciplines, using the notion that Engineering Science can act as an “incubator” for new disciplines; and a diversity of views on the relationship between science and engineering within Engineering Science programs. Finally, the paper paves a way forward for the next phase of the work, which involves interviewing program faculty and alumni to further understand perceptions of the discipline and the positioning of the discipline in the broader science and engineering landscape.
Editorial reprint: Call for a Canadian Public Mental Health System: Transformative change amid a global pandemic
Authors: Khanlou Nazilla 
Published: June 2020

This Editorial was previously published in the Journal of Concurrent Disorders, https://concurrentdisorders.ca/and is reprinted here with permission of the editor.
Original source:
Khanlou N. (2020). Editorial: Call for a Canadian Public Mental Health System: Transformative change amid a global pandemic. Journal of Concurrent Disorders, 2(1), 1-2. Available url: https://concurrentdisorders.ca/2020/03/31/call-for-a-canadian-public-mental-health-system/
Article reprint: Nurses respond to COVID-19 pandemic: Mental health support for frontline nurses
Authors: Khanlou Nazilla , Orazietti Brenda E. 
Published: June 2020

This article was previously published in the Journal of Concurrent Disorders, https://concurrentdisorders.ca/ andis reprinted here with permission of the editor.
Original source:
Khanlou N & Orazietti BE. (2020). Nurses respond to COVID-19 pandemic: Mental health support for frontline nurses. Journal of Concurrent Disorders, 2(1), 74-76. Available url: https://concurrentdisorders.ca/2020/04/11/nursesrespond-to-covid19-pandemic-mental-healthsupport-for-frontline-nurses/
Comment on « N-terminal Protein Tail Acts as Aggregation Protective Entropic Bristles : The SUMO Case »
Authors: Sénéchal Magalie , Bouchenna Jennifer , Vicogne Jérôme , Melnyk Oleg 
Published: June 2020

We provide a robust protocol for the far-UV CD analysis of SUMO-2 protein and SUMO-2 core domain as well as all the data as supplementary files for those interested by the study of SUMO protein conformation.These analyses were performed after having read the report published in 2014 by Grana-Montes, R. et al. (Grana-Montes, R.; Marinelli, P.; Reverter, D.; Ventura, S., N-terminal protein tails act as aggregation protective entropic bristles: the SUMO case. Biomacromolecules 2014, 15 (4), 1194-203. DOI: 10.1021/bm401776z).
The Effectiveness Of The Implementation Of Experiences Framework, Language, Pictures, Symbols, And Application (ELPSA) Cooperative Setting Of Students Teams Achievemet Division (STAD) Type In Mathematics Subjects On Set Material Of Grade VII at SMPN 29 In Bulukumba
Authors: Reskiawan Dwinto 
Published: June 2020

The research aimed at describing the Effectiveness of Experiences, Language, Picture, Symbols, and Application (ELPSA) on Cooperative Setting of Students Teams Achievement Division (STAD) Type in Mathematics Subjects on class X SMP Negeri 29 Bulukumba. The populations of this research were all students of grade class X SMP Negeri 29 Bulukumba and choose one class as the sample of the research by using simple random sampling as the experiment class, clas VII A, was given the treatment of Experiences, Language, Picture, Symbol, and Apllication (ELPSA) Cooperative Setting on STAD type. The data collections consisted of the data of learning model implementation, data of students’ activities, in learning process, data of students’ response on learning instruments, and data of students’ learning result which consisted of the pretest and posttest scores. The data of learning model implementation, students’ activities, and students’ response data were analyzed by using statistic descriptive analysis; whereas, mathematics learning result os students was analyzed by employing statistics descriptive and statistics inferential analysis. The results of the research revealed that (1) the average score of learning implementation level (TKP) was in good criteria (3.50 ≤ x ≤ 4.50) which was 3.17; (2) the average score of students’ activity had met sufficiently active criteria (2.5 – 3.4) which was 2.87; (3) students’ responds is in positive category (3.50 – 4.0) which was 3.51; (4) the everage of students’ learning result before the treatment was in very low category (0 – 54) which was 31.37 from the ideal score 100. The everage of students’ learning result after the treatment was in high category (80-89) which was 81.68 from the ideal score of 100. The everage of students’ improvement score (gain value) was in high category (x ≥ 0.7) which was 0,73. Based on inferential statistic analysis on students’ learning result after the treatment, it was obtained P-value < α (0.01 < 0.05) so H0 was rejected and H1 was accepted where the everage of students’ learning result was higher than 74.9 (KKM), and the everage of students’ learning improvement score (gain value) obtained P-value < α (0.01 < 0.05), so H0 was rejected and H1 was accepted where the everage of students improvement score (gain value) was higher than 0.29. Based on the results of the analysis of the level of holistic learning effectiveness concluded that the implementation of Experiences, Language, Picture, Symbol, and Apllication (ELPSA) on Cooperative Setting of Students Teams Achievement Division (STAD) Type is quite effective to be implemented in Mathematics subjects on class X SMP Negeri 29 Bulukumba.
Relationship of human heterochromatin and congenital malformations
Authors: Hasanova A.T.  , Jafarova G.A.  
Published: June 2020

Aim. The variability of centromeric heterochromatin of the chromosome pairs 1,9 and 16 was studied in material pro- vided by the Cytogenetic Counselling Centre.
Materials and methods. The size of bands 1q12, 9q12 and 16q11 was classified as normal, larger, very large, narrow and pericentric inversion. The karyotypes under study were divided into four groups: (I) from persons with abnormal karyotype and abnor-mal phenotype, ( I I ) from persons with abnormal phenotype and normal karyotype, (III) from healthy nearest relatives (parents and sibs) of persons with abnormal phenotype and karyotype, (I V ) from normal healthy persons with normal phenotype and karyotype without any congenital malformations in the family history.
Results. A different variability of centromeric hetero-chromatin of chromosomes 1 , 9 and 16 was observed. Quite a low variability was found in chromosome 16, while chromosomes 9 and 1 showed a high degree of variability, which was more accentuated in chromosome 9 than in chromo-some 1 .
Conclusions. In all four groups there was a similar pattern of variability with the only exception in the group of nearest relatives of children with abnormal phenotype and karyotype where an unusually narrow band 1q12 was more fre- quently detected.
Osteosarkomalar zamanı axıcı sitometrik parametrlərin təyini
Authors: Muradov H.K.  , Huseynov E.R.  , Ibrahimova F.H.  
Published: June 2020

Tədqiqatın məqsədi. Osteosarkomalar zamanı axıcı sitofluorimetrik müayinələrin aparılması.
Tədqiqatın material və metodları. Tədqiqat qrupunda osteosarkomalı xəstələrin axıcı-sitometrik müayinəsini
96 xəstə təşkil etmişdir. Osteosarkoma daha çox qamış sümüyünün metafizin, distal hissəsində, incik sümüyünün proksimal hissəsində, çiyin sümüyün proksimal hissəsidə lokallaşmışdır. DNT tədqiqi FACSCAN (Becton Dickinson, USA) axıcı sitofluometrində aparılmışdır.
Nəticələr. Axıcı-sitometrik cəhətdən bütün populyasiya çox klonlu olmuşdur, populasiyada aneuploid hüceyrələrin xeyli miqdarı (53%) və yüksək DNT indleksinin (2,5%) səviyyəsi ilə xarakterizə olunmuşdur. Osteosarkomada əsas terapiya radikal cərrahi müdaxilədən ibarətdir, əlavə kimyəvi terapiya kliniki qeyd olunmayan metastazların qarşısını almaq məqsədi güdür. Osteosarkoma zamanı proqnoz neqativdir və 5-illik yaşama müddəti 18,5% təşkil etmişdir.
Analisa Desain Konstruksi Tanggul Laut untuk Meminimalisir Hilangnya Garis Pantai Pasca Tsunami Tahun 2018 di Teluk Palu
Authors: Fiqi Bondan 
Published: June 2020

Tahun 2018 cukup berat dirasakan oleh warga pesisir Teluk Palu, dimana bencana alam seperti gempa bumi, likuifaksi dan tsunami harus terjadi disaat bersamaan dan pada waktu senja hari. Ketika hampir semua masyarakat berada di rumah setelah seharian beraktifitas. Peristiwa tersebut menyebabkan korban jiwa yang sangat banyak, dan begitu juga kerusakan infrastruktur yang tidak sedikit. Termasuk munculnya problem baru yang massif dan akan terus berjalan, berupa terkikisnya garis pantai pada wilayah teluk Palu yang meningkat signifikan pasca kejadian tersebut. Oleh sebab itu pemerintah dan masyarakat harus bangkit untuk membangun kembali infrastruktur sebagai langkah pemulihan, termasuk perlu dibuat sebuah tanggul laut untuk meminimalisir terkikisnya garis pantai pada wilayah teluk Palu. Tanggul laut yang dibangun harus memenuhi kriteria sains, supaya tidak terjadi gagal teknologi yang menyebabkan kerugian negara. Setelah dilakukan pengkajian terhadap beberapa referensi terkait dan simulasi menggunakan aplikasi delft 3D, maka disarankan bahwa pada kurun waktu 100 tahun terakhir prediksi kecepatan agin adalah kecepatan angin 10,35 m/s di area Teluk Palu, maka tinggi tide mencapai 1,45 m; nilai maksimum storm surge sekitar 0,086 m; kondisi wave antara 0,90 hingga 1,25 m; dan sea level rise rata – rata per tahun adalah 0,075 cm. Sehingga apabila dikalkulasi akan di dapat saran pembangunan tanggul laut dengan ketinggian mencapai 2,5 – 2,861 m. Kata kunci: tembok laut, pemodelan, palu, gelombang, tinggi air laut
Jovens cristãos on-line. Uma reflexão ético-teológica da Exortação apostólica Christus Vivit sobre o ambiente digital
Authors: Almeida André Luiz Boccato de , Silva Lúcia Eliza Ferreira da 
Published: June 2020

O presente artigo apresenta uma leitura analítica dos números 86-90 da Exortação Apostólica Christus Vivit, com o objetivo de com- preender a complexidade da interação entre evangelização e mídias atuais, particularmente entre os jovens. Para isso, disserta sobre o tema a partir de três perspectivas: a) situando a Exortação pós-sino- dal Christus Vivit (CV) em relação aos desafios da evangelização dos jovens; b) apresentando o ambiente digital com seus desafios; c) salientando as propostas de caráter ético-teológico e formativo da consciência.Abstract: His article presents an analytical reading of numbers 86-90 of the Apostolic Exhortation Christus Vivit, with the aim of understanding the complexity of the interaction between evangelization and current media, particularly among young people. To do so, he talksabout the subject from three perspectives: a) placing the post-synodal exhortation Christus Vivit (CV) in relation to the challenges of evangelizing young people; b) presenting the digital environment with its challenges; c) emphasizing the proposals of an ethical-theological and formative character of conscience.Keywords: Digital Environment; Christus Vivit; Evangelization; Pope Francis; Young.
As mídias e as mediações da experiência religiosa
Authors: Rodrigues Luís Miguel Figueiredo 
Published: June 2020

Este artigo discute a possibilidade de as mídias digitais poderem mediar também a experiência religiosas, estando, assim, ao serviço da evangelização. Segue de perto o pensamento de Bernard Lonergan para, em articulação com a cultura digital, se perceber como a autotranscedênciado sujeito pode ocorrer na sociedade rede (Manuel Castells) e no espaço do saber (Pierre Lévy).Abstract: This paper examines the possibility that digital media may also mediate religious experience, at the service of evangelization. It closely follows the thinking of Bernard Lonergan to, in articulation with the digital culture, to perceive how the self-transcendence of the subject can occur in the network society (Manuel Castells) and in the space of knowledge (Pierre Lévy).Keywords: Digital media; Bernard Lonergan; Self-transcendence; Evangelization.