bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating Polar Cap Density and Medium‐Frequency Burst Source Heights Using 2fce Roar Radio Emissions
Authors: Burnett Adam C. , LaBelle James 
Published: September 2020

AbstractCompeting theories exist for the generation mechanism of auroral medium‐frequency burst (MFB). In an effort to constrain MFB source heights, this study analyzes 33 events in which MFB and auroral 2fce roar co‐occurred at Sondrestrom, Greenland. Using measurements from an array of receiving antennas, direction‐of‐arrival calculations indicate that in a given co‐occurrence, the elevation angle of MFB typically is higher than that of roar. Ray tracing is used to determine source heights of the MFB signals. Density profiles are obtained from the International Reference Ionosphere (IRI) and shifted in magnitude until each event's roar signals originate at heights where the frequency‐matching condition for 2fce roar generation is satisfied. This shifting method is validated using density measurements from the Sondrestrom incoherent scatter radar (ISR) facility for the two events with available ISR data. After shifting, ray tracing demonstrates that in 25 of the 33 events, burst originates at a height of about 200 km, lower than the typical altitude of peak electron density. However, ISR measurements show that the density profile is enhanced at low altitudes while MFB is observed, peaking in the E region rather than the F region. This finding implies that the MFB sources at 200 km are on the topside of the density peak, in a region of downward pointing density gradient, in qualitative agreement with the mechanism of MFB generation by Langmuir waves in the topside ionosphere. These results also suggest a new method of estimating density in the polar cap using roar signals to calibrate IRI profiles.
Asymmetric Internal Tide Generation in the Presence of a Steady Flow
Authors: Dossmann Yvan , Shakespeare Callum , Stewart Kial , Hogg Andrew McC. 
Published: September 2020

AbstractThe generation of topographic internal waves (IWs) by the sum of an oscillatory and a steady flow is investigated experimentally and with a linear model. The two forcing flows represent the combination of a tidal constituent and a weaker quasi‐steady flow interacting with an abyssal hill. The combined forcings cause a coupling between internal tides and lee waves that impacts their dynamics of IWs as well as the energy carried away. An asymmetry is observed in the structure of upstream and downstream IW beams due to a quasi‐Doppler shift effect. This asymmetry is enhanced for the narrowest ridge on which a superbuoyancy (ω > N) downstream beam and an evanescent upstream beam are measured. Energy fluxes are measured and compared with the linear model, that has been extended to account for the coupling mechanism. The structure and amplitude of energy fluxes match well in most regimes, showing the relevance of the linear prediction for IW wave energy budgets, while the energy flux toward IW beams is limited by the generation of periodic vortices in a particular experiment. The upstream‐bias energy flux—and consequently net horizontal momentum—described in Shakespeare (2020, https://doi.org/10.1175/JPO‐D‐19‐0179.1) is measured in the experiments. The coupling mechanism plays an important role in the pathway to IW‐induced mixing, that has previously been quantified independently for lee waves and internal tides. Hence, future parameterizations of IW processes ought to include the coupling mechanism to quantify its impact on the global distribution of mixing.
MJO Wind Energy and Prediction of El Niño
Authors: Lybarger Nicholas D. , Shin Chul‐Su , Stan Cristiana 
Published: September 2020

AbstractThis study applies the energetic framework developed to quantify the interaction between the Madden‐Julian Oscillation (MJO) and El Niño–Southern Oscillation (ENSO) to El Niño forecasting. The MJO wind power, measured by the covariability of MJO‐related wind stress and oceanic Kelvin wave activity, is combined with the sea surface temperature (SST) anomalies, and two new indices are proposed. The MJO‐Kelvin wave‐ENSO (MaKE) index is proposed as an ENSO predictor and is shown to slightly outperform Niño 3.4 when applied to observational data sets and to greatly outperform Niño 3.4 when applied to CFSv2 reforecasts of the years 1980–2014. The MJO‐Kelvin wave Influence (MaKI) index is proposed to predict MJO influence on developing El Niño events. This index performs reasonably well when applied to observations. The forecast skill of MaKI in the CFSv2 reforecasts suggests that this model does not predict the observed MJO‐ENSO relationship as measured by this index.
The Vulcan Version 3.0 High‐Resolution Fossil Fuel CO2 Emissions for the United States
Authors: Gurney Kevin R. , Liang Jianming , Patarasuk Risa , Song Yang , Huang Jianhua , Roest Geoffrey 
Published: September 2020

AbstractEstimates of high‐resolution greenhouse gas (GHG) emissions have become a critical component of climate change research and an aid to decision makers considering GHG mitigation opportunities. The “Vulcan Project” is an effort to estimate bottom‐up carbon dioxide emissions from fossil fuel combustion and cement production (FFCO2) for the U.S. landscape at space and time scales that satisfy both scientific and policy needs. Here, we report on the Vulcan version 3.0 which quantifies emissions at a resolution of 1 km2/hr for the 2010–2015 time period. We estimate 2011 FFCO2 emissions of 1,589.9 TgC with a 95% confidence interval of 1,367/1,853 TgC (−14.0%/+16.6%), implying a one‐sigma uncertainty of ~ ±8%. Per capita emissions are larger in states dominated by electricity production and industrial activity and smaller where onroad and building emissions dominate. The U.S. FFCO2 emissions center of mass (CoM) is located in the state of Missouri with mean seasonality that moves on a near‐elliptical NE/SW path. Comparison to ODIAC, a global gridded FFCO2 emissions estimate, shows large total emissions differences (100.4 TgC for year 2011), a spatial correlation of 0.68 (R2), and a mean absolute relative difference at the 1 km2 scale of 104.3%. The Vulcan data product offers a high‐resolution estimate of FFCO2 emissions in every U.S. city, obviating costly development of self‐reported urban inventories. The Vulcan v3.0 annual gridded emissions data product can be downloaded from the Oak Ridge National Laboratory Distributed Active Archive Center (Gurney, Liang, et al., 2019, https://doi.org/10.3334/ORNLDAAC/1741).
Coupling of Phosphorus Processes With Carbon and Nitrogen Cycles in the Dynamic Land Ecosystem Model: Model Structure, Parameterization, and Evaluation in Tropical Forests
Authors: Wang Zhuonan , Tian Hanqin , Yang Jia , Shi Hao , Pan Shufen , Yao Yuanzhi , Banger Kamaljit , Yang Qichun 
Published: September 2020

AbstractThe biogeochemical processes of carbon (C), nitrogen (N), and phosphorous (P) are fully coupled in the Earth system, which shape the structure, functioning, and dynamics of terrestrial ecosystems. However, the representation of P cycle in terrestrial biosphere models (TBMs) is still in an early stage. Here we incorporated P processes and C‐N‐P interactions into the C‐N coupled Dynamic Land Ecosystem Model (DLEM‐CNP), which had a major feature of the ability in simulating the N and P colimitation on vegetation C assimilation. DLEM‐CNP was intensively calibrated and validated against daily or annual observations from four eddy covariance flux sites, two Hawaiian sites along a chronosequence of soils, and other 13 tropical forest sites. The results indicate that DLEM‐CNP significantly improved simulations of forest gross and net primary production (R2: 0.36–0.97, RMSE:1.1–1.49 g C m−2 year−1 for daily GPP at eddy covariance flux sites; R2 = 0.92, RMSE = 176.7 g C m−2 year−1 for annual NPP across 13 tropical forest sites). The simulations were also consistent with field observations in terms of biomass, leaf N:P ratio and plant response to fertilizer addition. A sensitivity analysis suggests that simulated results are reasonably robust against uncertainties in model parameter estimates and the model was very sensitive to parameters of P uptake. These results suggest that incorporating P processes and N‐P interaction into terrestrial biosphere models is of critical importance for accurately estimating C dynamics in tropical forests, particularly those P‐limited ones.
Effects of Anthropogenic Disturbances and Climate Change on Riverine Dissolved Inorganic Nitrogen Transport
Authors: Wang Yan , Xie Zhenghui , Liu Shuang , Wang Longhuan , Li Ruichao , Chen Si , Jia Binghao , Qin Peihua , Xie Jinbo 
Published: September 2020

AbstractNitrogen (N) transport from land to rivers, estuaries, and coastal marine systems has been markedly altered by anthropogenic and climatic drivers over recent decades. In this study, a riverine N transport scheme considering anthropogenic N discharge and water regulation was incorporated into the Land Surface Model of the Chinese Academy of Sciences (CAS‐LSM). Seven groups of simulations using the developed model at the global scale for the period of 1981–2010 were conducted to investigate the effects of anthropogenic disturbances and climate change on riverine dissolved inorganic nitrogen (DIN) transport. It was shown that fertilization and point source pollution have enhanced the DIN fluxes in rivers across the world, especially in western Europe and eastern China. The DIN exports were significantly reduced due to retention by reservoirs and the withdrawal of surface water and groundwater, with a retention efficiency of 50–70%. Climate variability and trends increased or decreased the riverine DIN fluxes depending on the specific hydroclimatic conditions. We further analyzed the contributions of climatic and anthropogenic changes to the riverine DIN changes in four major rivers. The riverine DIN exports in the Mississippi River Basin were affected primarily by fertilization, while the changes in DIN exports of the Danube were dominated by point source pollution and water regulation. The Yangtze River in China was seriously affected by both fertilization and point source pollution, and water regulation played a significant role in reducing DIN exports. Climate variability was the primary factor explaining the interannual variability of DIN exports.
Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study
Authors: Chen Qing , Wang Jing , Wang Jing , Lin Jing , Chen Lin , Lin Li-song , Pan Li-zhen , Shi Bin , Qiu Yu , Zheng Xiao-yan , Chen Fa , He Bao-chang , Liu Feng-qiong 
Published: September 2020

Abstract
Objectives
Evidence about ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte ω-3 PUFAs with the risk of oral cancer in a population from China.

Methods
Erythrocyte ω-3 PUFAs of 236 oral cancer patients and 300 controls were determined by gas chromatography. Restricted cubic spline and logistic regression were used to analyze the association between erythrocyte ω-3 PUFAs and oral cancer risk. The crude and adjusted OR with 95% CI was calculated. Stratification analysis was performed to explore the potential interaction between ω-3 PUFAs and other traditional risk factors such as smoking and drinking.

Results
Eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA) and ω-3 index were negatively but non-linearly related to risk of oral cancer as observed by restricted cubic spline. The adjusted OR of EPA, DHA, and ω-3 index were 0.52 (95% CI: 0.35–0.76), 0.19 (95% CI: 0.08–0.44), 0.20 (95% CI: 0.09–0.44), respectively. Stratification analysis showed that the adverse correlation between EPA and oral cancer was only significant in the non-smoking group, while the adverse correlation of ɑ-linolenic acid (ALA), EPA, and DHA were only significant in the non-drinking group. General multiplicative interactions were observed between ω-3 PUFAs and smoking or drinking.

Conclusions
Adverse but non-linear associations were observed between erythrocyte EPA, DHA, ω-3 index, and oral cancer risk. Additionally, there were multiplicative interactions between ω-3 PUFAs and other behavior factors such as smoking and drinking. The protective effect of ω-3 PUFAs maybe more significant in the non-smoking or non-drinking population.
The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank
Authors: García-González Judit , Ramírez Julia , Howard David M. , Brennan Caroline H. , Munroe Patricia B. , Keers Robert 
Published: September 2020

AbstractWhile psychotic experiences are core symptoms of mental health disorders like schizophrenia, they are also reported by 5–10% of the population. Both smoking behaviour and genetic risk for psychiatric disorders have been associated with psychotic experiences, but the interplay between these factors remains poorly understood. We tested whether smoking status, maternal smoking around birth, and number of packs smoked/year were associated with lifetime occurrence of three psychotic experiences phenotypes: delusions (n = 2067), hallucinations (n = 6689), and any psychotic experience (delusions or hallucinations; n = 7803) in 157,366 UK Biobank participants. We next calculated polygenic risk scores for schizophrenia (PRSSCZ), bipolar disorder (PRSBP), major depression (PRSDEP) and attention deficit hyperactivity disorder (PRSADHD) in 144,818 UK Biobank participants of European ancestry to assess whether association between smoking and psychotic experiences was attenuated after adjustment of diagnosis of psychiatric disorders and the PRSs. Finally, we investigated whether smoking exacerbates the effects of genetic predisposition on the psychotic phenotypes in gene-environment interaction models. Smoking status, maternal smoking, and number of packs smoked/year were associated with psychotic experiences (p < 1.77 × 10−5). Except for packs smoked/year, effects were attenuated but remained significant after adjustment for diagnosis of psychiatric disorders and PRSs (p < 1.99 × 10−3). Gene-environment interaction models showed the effects of PRSDEP and PRSADHD (but not PRSSCZ or PRSBP) on delusions (but not hallucinations) were significantly greater in current smokers compared to never smokers (p < 0.002). There were no significant gene-environment interactions for maternal smoking nor for number of packs smoked/year. Our results suggest that both genetic risk of psychiatric disorders and smoking status may have independent and synergistic effects on specific types of psychotic experiences.
Multiple myeloma current treatment algorithms
Authors: Rajkumar S. Vincent , Kumar Shaji 
Published: September 2020

AbstractThe treatment of multiple myeloma (MM) continues to evolve rapidly with arrival of multiple new drugs, and emerging data from randomized trials to guide therapy. Along the disease course, the choice of specific therapy is affected by many variables including age, performance status, comorbidities, and eligibility for stem cell transplantation. In addition, another key variable that affects treatment strategy is risk stratification of patients into standard and high-risk MM. High-risk MM is defined by the presence of t(4;14), t(14;16), t(14;20), gain 1q, del(17p), or p53 mutation. In this paper, we provide algorithms for the treatment of newly diagnosed and relapsed MM based on the best available evidence. We have relied on data from randomized controlled trials whenever possible, and when appropriate trials to guide therapy are not available, our recommendations reflect best practices based on non-randomized data, and expert opinion. Each algorithm has been designed to facilitate easy decision-making for practicing clinicians. In all patients, clinical trials should be considered first, prior to resorting to the standard of care algorithms we outline.
Genome-wide association study reveals the genetic determinism of growth traits in a Gushi-Anka F2 chicken population
Authors: Zhang Yanhua , Wang Yuzhe , Li Yiyi , Wu Junfeng , Wang Xinlei , Bian Cheng , Tian Yadong , Sun Guirong , Han Ruili , Liu Xiaojun , Jiang Ruirui , Wang Yanbin , Li Guoxi , Li Wenting , Hu Xiaoxiang , Kang Xiangtao 
Published: September 2020

AbstractChicken growth traits are economically important, but the relevant genetic mechanisms have not yet been elucidated. Herein, we performed a genome-wide association study to identify the variants associated with growth traits. In total, 860 chickens from a Gushi-Anka F2resource population were phenotyped for 68 growth and carcass traits, and 768 samples were genotyped based on the genotyping-by-sequencing (GBS) method. Finally, 734 chickens and 321,314 SNPs remained after quality control and removal of the sex chromosomes, and these data were used to carry out a GWAS analysis. A total of 470 significant single-nucleotide polymorphisms (SNPs) for 43 of the 68 traits were detected and mapped on chromosomes (Chr) 1–6, -9, -10, -16, -18, -23, and -27. Of these, the significant SNPs in Chr1, -4, and -27 were found to be associated with more than 10 traits. Multiple traits shared significant SNPs, indicating that the same mutation in the region might have a large effect on multiple growth or carcass traits. Haplotype analysis revealed that SNPs within the candidate region of Chr1 presented a mosaic pattern. The significant SNPs and pathway enrichment analysis revealed that theMLNR,MED4,CAB39L,LDB2, andIGF2BP1genes could be putative candidate genes for growth and carcass traits. The findings of this study improve our understanding of the genetic mechanisms regulating chicken growth and carcass traits and provide a theoretical basis for chicken breeding programs.
Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype
Authors: Manakhov Andrey D. , Mintseva Maria Yu. , Andreev Igor A. , Uralsky Lev I. , Andreeva Tatiana V. , Trapezov Oleg V. , Rogaev Evgeny I. 
Published: September 2020

AbstractOver 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.
Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease
Authors: Watanabe Toshihiro , Fujimoto Yuki , Morimoto Aya , Nishiyama Mai , Kawai Akinori , Okada Seiki , Aiba Motohiro , Kawano Tomoharu , Kawahigashi Mina , Ishizu Masashi , Mori Hiroyasu , Matsuhisa Munehide , Hata Akiko , Funaki Makoto , Hashida Seiichi 
Published: September 2020

AbstractGlomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance over conventional biomarkers were investigated. The T-AN and H-AN assays had high reproducibility, good linearity, and sufficient sensitivity to detect trace amounts of adiponectin in the urine. Urine samples after gel filtration were analyzed for the presence of different molecular isoforms. Low molecular weight (LMW) forms and monomers were the major components (93%) of adiponectin in the urine from a diabetic patient with normoalbuminuria. Urine from a microalbuminuria patient contained both high molecular weight (HMW) (11%) and middle molecular weight (MMW) (28%) adiponectin, although the LMW level was still high (52%). The amount of HMW (32%) and MMW (42%) were more abundant than that of LMW (24%) in a diabetic patient with macroalbuminuria. T-AN (r = − 0.43) and H-AN (r = − 0.38) levels showed higher correlation with estimated GFR (eGFR) than UAER (r = − 0.23). Urinary levels of both T-AN and H-AN negatively correlated with renal function in diabetic patients and they may serve as new biomarkers for diabetic kidney disease.
Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
Authors: Ismail Aishah , Chen Hui Cheng , Faye Ibrahima , Tang Tong Boon 
Published: September 2020

AbstractReal-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75% stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye.
Chromosomal abnormalities and atrial fibrillation and ischemic stroke incidence: a nationwide population-based study
Authors: Cho Jun Hwan , Choi Eue-Keun , Moon In-Ki , Jung Jin- Hyung , Han Kyung-Do , Choi You-Jung , Park Jiesuck , Lee Euijae , Lee So- Ryoung , Cha Myung-Jin , Lim Woo-Hyun , Oh Seil 
Published: September 2020

AbstractThere is a paucity of information as to whether chromosomal abnormalities, including Down Syndrome, Turner Syndrome, and Klinefelter Syndrome, have an association with atrial fibrillation (AF) and ischemic stroke development. Data from 3660 patients with Down Syndrome, 2408 with Turner Syndrome, and 851 with Klinefelter Syndrome without a history of AF and ischemic stroke were collected from the Korean National Health Insurance Service (2007–2014). These patients were followed-up for new-onset AF and ischemic stroke. Age- and sex-matched control subjects (at a ratio of 1:10) were selected and compared with the patients with chromosomal abnormalities. Down Syndrome patients showed a higher incidence of AF and ischemic stroke than controls. Turner Syndrome and Klinefelter Syndrome patients showed a higher incidence of AF than did the control group, but not of stroke. Multivariate Cox regression analysis revealed that three chromosomal abnormalities were independent risk factors for AF, and Down Syndrome was independently associated with the risk of stroke. In conclusion, Down Syndrome, Turner Syndrome, and Klinefelter Syndrome showed an increased risk of AF. Down Syndrome patients only showed an increased risk of stroke. Therefore, AF surveillance and active stroke prevention would be beneficial in patients with these chromosomal abnormalities.