bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actor Critic Deep Reinforcement Learning for Neural Malware Control
Authors: Wang Yu , Stokes Jack , Marinescu Mady 
Published: June 2020

In addition to using signatures, antimalware products also detect malicious attacks by evaluating unknown files in an emulated environment, i.e. sandbox, prior to execution on a computer's native operating system. During emulation, a file cannot be scanned indefinitely, and antimalware engines often set the number of instructions to be executed based on a set of heuristics. These heuristics only make the decision of when to halt emulation using partial information leading to the execution of the file for either too many or too few instructions. Also this method is vulnerable if the attackers learn this set of heuristics.
Recent research uses a deep reinforcement learning (DRL) model employing a Deep Q-Network (DQN) to learn when to halt the emulation of a file. In this paper, we propose a new DRL-based system which instead employs a modified actor critic (AC) framework for the emulation halting task. This AC model dynamically predicts the best time to halt the file's execution based on a sequence of system API calls. Compared to the earlier models, the new model is capable of handling adversarial attacks by simulating their behaviors using the critic model. The new AC model demonstrates much better performance than both the DQN model and antimalware engine's heuristics. In terms of execution speed (evaluated by the halting decision), the new model halts the execution of unknown files by up to 2.5% earlier than the DQN model and 93.6% earlier than the heuristics. For the task of detecting malicious files, the proposed AC model increases the true positive rate by 9.9% from 69.5% to 76.4% at a false positive rate of 1% compared to the DQN model, and by 83.4% from 41.2% to 76.4% at a false positive rate of 1% compared to a recently proposed LSTM model.
Real-World Treatment Patterns and Progression-Free Survival Associated with Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitor Therapies for ALK+ Non-Small Cell Lung Cancer
Authors: Jahanzeb Mohammad , Lin Huamao M. , Pan Xiaoyun , Yin Yu , Wu Yanyu , Nordstrom Beth , Socinski Mark A. 
Published: June 2020

Abstract

Background
Little is known about real-world treatment and outcomes of patients with anaplastic lymphoma kinase-positive (ALK+) advanced non-small cell lung cancer (NSCLC).

Patients and Methods
This retrospective study of the Flatiron Health EHR-derived deidentified database included patients with a lung cancer diagnosis and confirmed advanced NSCLC who received ALK tyrosine kinase inhibitor (TKI) therapy (January 1, 2011, through June 30, 2018). Patient characteristics and treatment patterns were characterized. Real-world progression-free survival (rwPFS) and time to discontinuation were calculated using the Kaplan-Meier method.

Results
First-line ALK TKI therapy was administered to 581 patients (27.5% had brain metastasis on or prior to initiation) and second-line ALK TKI therapy to 254 patients post crizotinib (45.7% had brain metastasis on or prior to second-line ALK TKI initiation). Crizotinib (84.6%; n = 492) was the most commonly administered first-line ALK TKI therapy. For second-line ALK TKI post crizotinib (n = 254), 49.6% received ceritinib, 41.7% received alectinib, 5.9% received crizotinib retreatment, and 2.8% received brigatinib. Median (95% confidence interval [CI]) rwPFS was 7.47 (6.48–8.32) months for first-line and 7.30 (5.72–8.42) months for second-line ALK TKI. Median (95% CI) rwPFS was significantly longer among first-line ALK TKI patients without than with brain metastasis (8.52 [7.57–10.59] vs. 4.97 [3.75–5.99] months; p &lt; .0001) and patients with brain metastasis on or prior to first-line ALK TKI therapy had a significantly increased risk of progression (hazard ratio ± SE, 1.976 ± 0.112; p &lt; .0001).

Conclusion
Median rwPFS in patients with advanced ALK+ NSCLC was &lt; 8 months for first- and second-line ALK TKI therapy and was even shorter in patients with brain metastasis, highlighting the need for more effective treatments in this patient population.
LAMOTRİGİNE BAĞLI OLASI DRESS SENDROMU: OLGU SUNUMU
Authors: UYGUR KÜLCÜ Nihan , ERDEDE Özlem , DOĞRU Mahmut , ERASLAN Gökçe Ezgi , SARI Erdal , YILDIZ Feyza 
Published: June 2020

DRESS Sendromu (Drug Rush with Eosinophilia and Systemic Symptoms) ilaç ilişkili döküntü, hematolojik anormallikler (eozinofili, atipik lenfositoz), lenfadenopati, iç organ tutulumları (karaciğer, böbrek, akciğer) ile seyreden nadir, hayatı tehdit edebilen hipersensitivite reaksiyonudur. Antiepileptik lamotrigin tedavisi başlandıktan on dört gün sonra döküntüsü ve ateşi gelişen DRESS Sendromu olduğu düşünülen ergen bir kız hastayı sunduk.
Hubungan Power Tungkai dengan Hasil Tendangan Mawashi Geri dan Ushiro Mawashi-Geri pada Cabang Olahraga Karate
Authors: Kusmirantini Sari Yurika , Imanudin Iman 
Published: June 2020

Dalam olahraga karate teknik tendangan yang biasa dilakukan oleh atlet adalah teknik tendangan mawashi geri dan ushiro mawashi-geri, namun teknik tersebut masih jarang menghasilkan poin karena kurangnya power seorang atlet saat melakukan tendangan tersebut. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara power tungkai dengan hasil tendangan mawashi geri dan ushiro mawashi-geri pada cabang olahraga karate. Metode penelitian yang digunakan adalah metode kuantitatif dengan studi korelasional. Sampel yang digunakan dalam penelitian ini adalah mahasiswa UKM Karate UPI sebanyak 10 orang yang telah mengikuti berbagai event Nasional.Instrumen yang digunakan dalam penelitian ini adalah digital vertical jump dan nuboya meter dengan validitas sebesar 0,70 dan reabilitas 0,72.. Hasil analisis data dari penelitian menunjukan bahwa terdapat hubungan antara power tungkai dengan hasil tendangan mawashi geri dan ushiro mawashi-geri pada cabang olahraga karate. Hal ini terlihat dari nilai hasil tendangan yaitu 0,815 dengan signifikansi 0,004 0,05 dan 0,782 dengan signifikansi 0,008 0,05. hal ini menggambarkan bahwa power tungkai merupakan faktor penting untuk menghasilkan tendangan mawashi geri dan ushiro mawashi-geri. Dengan kata lain semakin besar power tungkai maka semakin baik upaya menendang dari sisi kekuatan dan kecepatan. Kata kunci: karate, tendangan mawashi geri dan ushiro mawashi-geri, dan power tungkai.
Pengembangan Alat Ukur Hurdle Jump untuk Kekuatan Daya Tahan Otot Tungkai Berbasis Sensor Ultrasonik
Authors: Qiefrydzannath Qiefrydzannath , Rusdiana Agus 
Published: June 2020

Penelitian ini mengambil judul “Pengembangan Alat Ukur Hurdle Jump untuk Daya Tahan Otot Tungkai Berbasis Sensor Ultrasonik” untuk menciptakan alat ukur yang dapat dijadikan sebagai teknologi dalam olahraga yang dapat menghasilkan hasil tes dengan tingkat validitas yang tinggi. pengetesan dengan penerapan menggunakan teknologi merupakan solusi untuk memudahkan manusia dalam perhitungan. Perkembangan pesat teknologi modern yang diterapkan dalam bidang olahraga khususnya di negara-negara maju menjadi alasan untuk membuat alat seperti pada penelitian ini. Penelitian ini bertujuan untuk mengembangkan alat ukur hurdle jump yang dilengkapi sensor ultrasonik. .10 orang mahasiswa program studi Ilmu Keolahragaan berpartisipasi sebagai sampel dalam penelitian kali ini. Penelitian ini menggunakan pendekatan metode Research and Development (RD). Alat yang digunakan menggunakan rangkaian elektronika berbasis sensor ultrasonik dan mikrokontroller. Alat ini bekerja otomatis dengan menekan tombol start pada box ditandai dengan suara buzzer sebanyak 3 kali sebagai tanda test akan dimulai. Ketika sampel melakukan lateral jump selama 60 detik maka alat ini secara ototmatis akan menghitung gerakan hurdle jump ditandai dengan suara buzzer ketika masuk dalam point dan buzzer akan berbunyi ketika durasi waktu sudah habis. Hasil tampilan waktu dan hasil gerakan hurdle jump akan tertera pada LCD yang terletk pada permukaan box. . Diharapkan hasil penelitian ini dapat membantu dunia keolahragaan Indonesia atau setidaknya menjadi pemicu munculnya ide-ide baru yang lebih baik.
Pengaruh Metode PETTLEP dan Media Audio Visual Terhadap Hasil Belajar Keterampilan Jurus Tunggal Baku Pencak Silat
Authors: Ajid Oktoviana Nur , Komarudin Komarudin , Mulyana Mulyana 
Published: June 2020

Abstract Tujuan penelitian ini untuk melihat pengaruh metode PETTLEP dan media audio visual terhadap pembelajaran jurus tunggal baku pencak silat. Sampel dalam penelitian ini adalah tiga puluh pesilat pemula yaitu mahasiswa program studi ilmu keolahragaan FPOK UPI dengan pengalaman latihan 2 bulan. Metode yang digunakan eksperimen dengan desain the randomized pretest posttest control grup. Analisis data menggunakan SPSS versi 23 dengan pengujian hipotesis melalui independent sample t test dan one way anova. Hasil analisis dan perhitungan data mengungkapkan bahwa 1) Terdapat pengaruh metode PETTLEP terhadap hasil belajar keterampilan jurus tunggal baku pencak silat 2) Terdapat pengaruh media audio visual terhadap hasil belajar keterampilan jurus tunggal baku pencak silat 3) Terdapat pengaruh metode demonstrasi terhadap hasil belajar keterampilan jurus tunggal baku pencak silat 4) Terdapat perbedaan yang signifikan antara metode PETTLEP, media audio visual, dan metode demonstrasi terhadap hasil belajar keterampilan jurus tunggal baku pencak silat.. Abstract The purpose of this study was to see the effect of the PETTLEP method and audio-visual media on learning of the jurus tunggal baku of Pencak Silat. The sample in this study was thirty beginner martial artists which are the students of FPOK UPI Sports Science Study Program with 2 months training experience. Experiment method was conducted with the randomized pretest posttest control group design. The data was analyzed using SPSS version 23 by testing hypotheses through independent sample t test and one-way ANOVA. The results of the analysis and calculation of the data revealed that 1) There is an effect of the PETTLEP method on the learning outcomes of the jurus tunggal baku of pencak silat 2) There is an effect of the audiovisual media on the results of the learning skills of the jurus tunggal baku of Pencak Silat 3) There is an effect of the demonstration method on the learning outcome of the jurus tunggal baku of Pencak Silat 4) There is a significant difference between the PETTLEP method, audio visual media, and the demonstration method towards the results of learning the skills of a jurus tunggal baku of Pencak Silat.
Hubungan Tingkat Intelligence Qoutient (IQ) dan Bakat dengan Hasil Kejuaraan Senam POPDA DIY
Authors: Widanita Neva , Sukamti Endang Rini , Festiawan Rifqi 
Published: June 2020

AbstrakPenelitian ini bertujuan untuk mengetahui hubungan tingkat IQ dan bakat dengan hasil kejuaraan POPDA senam di DIY. Metode yang digunakan adalah survei, dengan teknik pengumpulan data menggunakan tes dan pengukuran. Populasi dalam penelitian ini adalah seluruh atlet senam artistik dan ritmik yang mengikuti kejuaraan POPDA senam di Yogyakarta. Sampel yang diambil dari hasil purposive sampling, berjumlah 16 atlet. Analisis data menggunakan uji regresi korelasi. Hasil penelitian menunjukkan bahwa (1) tidak ada hubungan antara tingkat Intelligence quotient dengan hasil kejuaraan senam POPDA DIY, dengan nilai r hitung sebesar 0.187 0.400 r tabel dengan n = 16 pada signifikansi 5%, (2) Ada hubungan antara bakat dengan hasil kejuaran senam POPDA DIY, dengan nilai r hitung sebesar 0.956 0.400 r tabel dengan n = 16 pada signifikansi 5%, (3) Ada hubungan antara tingkat Intelligence quotient dan bakat terhadap hasil kejuaran senam POPDA DIY, dengan F hitung (113.316) (3.806) F tabel pada α = 5%. Dari hasil penelitian ini dapat disimpulkan bahwa ada hubungan antara tingkat Intelligence quotient dan bakat terhadap hasil kejuaran senam POPDA DIY sehingga hasil ini bisa menjadi salah satu acuan dalam meningkatkan prestasi khususnya di cabang olahraga senam. Abstract This study aims to determine the relationship of IQ and talent levels with the POPDA gymnastics championship results in DIY. The method used is a survey, with data collection techniques using tests and measurements. The population in this study were all artistic and rhythmic gymnastics athletes who participated in the POPDA gymnastics championship in Yogyakarta. Samples taken from the results of purposive sampling, amounting to 16 athletes. Data analysis using correlation regression test. The results showed that (1) there was no relationship between the intelligence quotient level with the results of the DIY POPDA gymnastics championship, with a calculated r value of 0.187 0.400 r table with n = 16 at a significance of 5%, (2) There was a relationship between talent and the outcome of the championship POPDA DIY gymnastics, with a calculated r value of 0.956 0.400 r table with n = 16 at a significance of 5%, (3) There is a relationship between the level of Intelligence quotient and talent on the results of POPDA DIY gymnastics, with an F count (113.316) (3.806) ) F table at α = 5%. From the results of this study it can be concluded that there is a relationship between the level of Intelligence quotient and talent on the results of the DIY POPDA gymnastics championship so that these results can be one of the references in improving achievement, especially in gymnastics.
EFEKTIVITAS PERMAINAN FLOWER CIRCUIT TERHADAP PERKEMBANGAN FISIK MOTORIK KASAR ANAK USIA 5-6 TAHUN
Authors: Haryanti Anggi Eka , Qolistiani Qolistiani 
Published: June 2020

Abstract: The purpose of this study was to determine the effectiveness of flower circuit games on the development of gross physical motor of group B children. The scope of this study was about gross motor skills that included elements of physical fitness such as strength, accuracy, agility and balance. This study uses a quantitative approach with the specifications of the study using quasi experiment research methods. Data from quantitative research results in the form of numerical values obtained from the calculation of the results of the pretest and posttest scores. The results of the calculation of pretest and posttest can be concluded that the flower circuit game is effective againts the development of gross motoric physicality of children in RA Al Huda Rejowinangun Trenggalek. Abstrak: Tujuan penelitian ini adalah mengetahui efektivitas permainan flower circuit pada pembelajaran fisik motorik kasar anak kelompok B. Ruang lingkup penelitian ini mengenai kemampuan motorik kasar yang mencakup unsur-unsur kebugaran jasmani seperti kekuatan, ketepatan, kelincahan dan keseimbangan. Penelitian ini menggunakan pendekatan kuantitatif dengan spesifikasi penelitian menggunakan metode penelitian quasi experiment (eksperimen semu). Data hasil penelitian kuantitatif berupa nilai angka yang diperoleh dari hasil perhitungan skor hasil pretest dan posttest. Hasil perhitungan pretest dan posttest dapat disimpulkan bahwa permainan flower circuit efektif terhadap perkembangan fisik motorik kasar anak kelompok B di RA Al Huda Rejowinangun Trenggalek.
Comparative evaluation of intrathecal preservative free isobaric 0.5% ropivacaine with isobaric 0.5% bupivacaine in patients undergoing lower abdominal surgeries
Authors: Jamwal Shyamli , Pathania Jyoti , Sood Ajay , Singh Vishawjeet , Bhardwaj Vatika 
Published: June 2020

Spinal anaesthesia is the frequently used central block used in a surgical procedure. Different local anaesthetic drugs used in spinal anaesthesia differ in their analgesic property, lipid solubility, protein binding, pKa, and degree of spread, the baricity of solution being one of the primary determinants of spread of solutions.To compare and evaluate the anaesthetic profile of preservative free 0.5% isobaric ropivacaine and bupivacaine in patients undergoing lower abdominal surgeries.The clinical study enrolled 100 patients posted for lower abdominal surgeries under spinal anaesthesia. All the patients were then randomized and received either isobaric preservative free 3ml(15mg) of 0.5% bupivacaine (Group A, n=50) or 3ml(15mg) of 0.5% ropivacaine (Group B, n=50). Onset and duration of sensory and motor blocks, haemodynamic changes and any other side effects were noted.Demographic variables between the two groups were not significant. Onset of sensory block was delayed in ropivacaine group B (4.80 ± 0.92 vs 4.35 ± 0.88 min, p &#60;0.05) than group A, whereas duration was found to be significantly more in group A (170.29 ± 14.14 vs 155.77 ± 13.97min, p&#60;0.05) than group B. Onset of motor block was also earlier in group A than group B with p value&#60; 0.05, whereas duration was significantly shorter in group B (140.08 ± 16.58 vs 160.95 ± 15.74min). The two groups were comparable in maximum level of blockade reached and haemodynamic parameters. Incidence of hypotension and bradycardia was significantly less in ropivacaine group.This study establishes that ropivacaine produces good sensory block and is more stable hemodynamically with lesser side effects.
Efficacy of diclofenac transdermal patch and diclofenac rectal suppository for postoperative pain management following open cholecystectomy: A single blind prospective comparative study
Authors: Ranjan Panigrahi Manas , Mukhapadhyay Bhabananda , Tanweer Md. 
Published: June 2020

Postoperative pain control is an important component of surgical patient care. Inadequate pain control in postoperative period increases mortality and morbidity to great extent. Studies have shown transdermal diclofenac is as effective as intramuscular diclofenac injection in postoperative analgesia, but a comparison of diclofenac rectal suppository and transdermal route is lacking. This research proposal intends to study and compare the effectiveness of Diclofenac transdermal patch and rectal suppository.Randomized, Single Blind, Prospective, Comparative study.ASA 1 and 2 patients scheduled for open cholecystectomy withsample size60 patients divided between group TD (transdermal patch, n=30) and RS (rectal suppository, n=30). 100 mg diclofenac epolamine patch was applied on inner aspect of left arm in TD group’s 1hr before incision Patch was changed 12hrly for 48 hrs. 100 mg diclofenac sodium was introduced per-rectally in PR group just before induction of anesthesia and repeated 12hrly for 48hrs. Each patient was monitored and data collected in PACU, PCA remote was again shown to patients and advised them to press button whenever they feel.It has been found that both the groups were comparable in their demographic distribution, in terms of age and sex. 14 readings were taken from just after OT till 48hrs from starting surgery. None of the patients in the study showed the sign or symptoms of opioid overdosing. The pain was better controlled with Diclofenac through per rectal route than the transdermal route.Considering mean rank of VAS till 6hrs after skin incision and drugs given during 1, 2 and 3 readings at 6 hr., 12 hr., 18 hr. and continue 6hrly and total drugs given till 48hrs, pain after open cholecystectomy was better controlled with diclofenac sodium rectal suppository in comparison to diclofenac epolamine patch.
The role of demystifying anaesthesia in allaying anxiety and improving post-operative patient satisfaction in a tertiary care centre: A randomised control trial
Authors: Mathew Anna , Koshy Preethy , Mariyam Shamjitha , Ipe Shaloo , Ramasami Prakash 
Published: June 2020

Preoperative anxiety and stress are inevitable in patients awaiting surgery. However it is known that larger doses of anaesthetics, higher peri- and post-operative requirement of analgesia and longer hospital stay follow higher levels of anxiety. Studies have shown that pre-operative education reduces anxiety symptoms. This studywas undertaken to answer the question: “Does a structured educational intervention to demystify anaesthesia reduce fear and anxiety prior to surgery?” To assess the role of patient education in reducing pre-operative anxiety and fear and improving satisfaction in patients undergoing surgery using the Anesthesia- and Surgery-dependent Preoperative Anxiety Scale (ASPA)and the Visual Analog Scale for fear and the Short Assessment of Patient Satisfaction (SAPS) in patients who have received the structured educational intervention and those who have not.This is aparallel group, single blinded, randomised control trial in 56 consenting patients awaiting abdominal surgery under general anesthesia. The participants were randomized to the interventional and comparator groups and ASPA and VAS were administered. Participants in Group A were given the structured educational intervention to demystify anesthesia. The ASPA and VAS Scales were again administered by a blinded assessor to all participants. The student investigator administered SAPS on the third post-operative day or prior to discharge, whichever was earlier. There was significant reduction in median scores before and after intervention for anxiety (ASPA=2) and fear (VAS=20) in intervention group compared to the comparator group. (p value=&#60;0.001). The median scores for patient satisfaction as measured by SAPS was also higher in the intervention group compared to the comparator group.(p value=0.042).There was a significant reduction of pre-operative fear and anxiety in the intervention group, while the patient satisfaction was also higher in the intervention group.
Thermal Analysis of Healthy and Ecological Friendly Flame Retardants for Textiles
Authors: Manich Albert M , Perez-Rentero Sonia , Alonso Cristina , Coderch Luisa , Martí Meritxell 
Published: June 2020

Flame Retardants (FR) are a group of anthropogenic environmental contaminants used at a relatively high concentration in many applications. Currently, the largest marked group of FRs is halogenated FR, and many of them are considered toxic, persistent and bio accumulative. Non-halogenated alternatives are a possible solution for the problem, but there is a lack of knowledge concerning environmental impact, health risks during the production process and final use. The main objective of the LIFE-FLAREX project that supports this work, is the mitigation of the environmental and human health impact of flame retardants used in textiles, looking for new efficient more ecological and healthy alternatives, able to replace the most common FR’s that include toxic compounds like halogens, formaldehyde and antimony. The aim of this work is to determine the effect of conventional and ecological flame retardants on cotton and polyester fabrics by the application of differential scanning calorimetry DSC and thermogravimetric analysis TGA. Results have been compared with those given by the best FR applied to cotton/polyester blended fabric. The application of DSC up to 550°Cand TGA up to 600°C in N2 and O2 atmospheres give results that are in accordance with those yielded by the micro-scale combustion calorimeter. Onset temperatures of decomposition, steps of loss of mass by temperature and final residues, enable to evaluate the thermal efficiency of the different flame retardants. Results have been compared with those given by the application of ammonium polyphosphate and guanidine phosphate on cotton/polyester 50/50 blend.
Keywords: Thermal Analysis, Flame retardant, Cotton, Polyester