bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracranial Metastases of Intramedullary Spinal Cord Low-Grade Astrocytoma
Authors: Sanei-Sistani Sharareh , Miri-Aliabad Ghasem , Dahmardeh Hamid , Montazeran Mahdieh , Jahantigh Mehdi , Zare Mohsen 
Published: April 2020

AbstractThis paper reports a case of intramedullary spinal cord low-grade (LG) astrocytoma that developed brain metastases after 21 months. A 6-year-old child presented with lower spine pain and falls during daily activity. A spinal cord mass was detected using spinal magnetic resonance imaging (MRI), and brain MRI was normal. The spinal lesion was partially resected, and pathological findings revealed LG astrocytoma (WHO Grade II). The patient underwent thoracolumbar radiotherapy. He returned 21 months following initial admission with symptoms of nausea, vomiting, headaches, and seizure. Brain MRI revealed multiple intracranial masses at the posterior fossa, left lateral ventricle, cerebellopontine angles, and left Meckel cave. A recurrent lesion was detected in the thoracic and lumbar regions of the spinal cord and in the cauda equina. The patient underwent chemotherapy. This rare case warns practitioners to monitor closely the cases of spinal cord astrocytoma that are diagnosed as LG tumors based on histology.
Multiple Small Bowel Perforations in a Patient of Chronic Myeloid Leukemia on Imatinib
Authors: Tadaiya Mahavir Virendra Kumar , Tankshali Rajen A 
Published: April 2020

AbstractChronic myeloid leukemia (CML) is a clonal hematopoietic disorder caused by an acquired genetic defect in a pluripotent stem cell. A series of discoveries led to the recognition that the BCR-ABL protein, which results from a reciprocal translocation involving chromosomes 9 and 22, has a central role in the pathogenesis of chronic myelogenous leukemia. The BCR-ABL protein functions as a constitutively activated tyrosine kinase (TK) and this knowledge led to the development of imatinib (STI-571), a drug that specifically inhibits the BCR-ABL TK. Common side effects of imatinib are low blood counts, nausea and vomiting, edema (swelling of the face, feet, and hands), muscle cramps and bone pain, diarrhea, hemorrhage, skin rash, and fever. Headache, fatigue, joint pain, indigestion, and abdominal pain are occasionally seen, and liver toxicity is a rare complication. We here report a case of multiple small bowel perforations in a patient of Ph+ve chronic myeloid leukemia-chronic phase on imatinib. Bowel perforation is a known complication for targeted therapy agents like bevacizumab, sunitinib, and sorafenib, which act on vascular endothelial growth factor receptor but imatinib having no anti VEGF receptor activity leading to such complication is a mystery. Physician treating their patient with imatinib should be aware of this complication and should act accordingly.
Receita de contrato com cliente (IFRS 15 / CPC 47): aspectos contábeis do segmento de medicina diagnóstica no Brasil
Authors: Aquino Carlos Elder Maciel de , Iudícibus Sérgio De , Santos Fernando De Almeida , Saporito Antonio 
Published: April 2020

Com a publicação da IFRS 15 - Revenue from Contracts with Customers as companhias passaram a reconhecer a receita de contrato com cliente numa base comum de princípios e orientações voltadas a determinar quando reconhecer receita e o valor que deve ser reconhecido. Este estudo verifica a aderência de empresas do segmento de medicina diagnóstica no Brasil à IFRS 15 / CPC 47. Não foram encontradas pesquisas que abordam o setor de saúde no Brasil. Esta pesquisa é caracterizada como exploratória, qualitativa e descritiva. Evidenciou-se que as empresas atendem aos requerimentos regulatórios para reconhecimento, mensuração e registro contábil, porém, não estão aderentes aos aspectos de uniformização, completude e transparência das informações divulgadas. Portanto, esta pesquisa contribui para a qualidade e padronização de registros, apresentação e divulgação contábil do ciclo de receita, permitindo avaliação de performance na gestão de recebíveis e melhor comparação entre empresas.
El ensayo de una ‘neue Aufklärung’ como preludio de la ‘filosofía experimental’ futura en Nietzsche
Authors: Barelli Maria Cecilia 
Published: April 2020

Nos proponemos indagar la recepción de la Ilustración en Friedrich Nietzsche. Encontramos en sus escritos publicados y póstumos no solo una evaluación o balance crítico de los alcances de este movimiento en sus distintas expresiones, sino también el ensayo de continuar con algunas de sus tareas, a partir de una praxis filosófica de carácter experimental. Consideramos, por lo tanto, que la noción de Aufklärung, con los giros y los matices esbozados por el propio pensador alemán, merecen un renovado y detenido análisis, tanto por los aportes que pueden hacerse en el campo de la exegesis crítica e histórica del corpus nietzscheano, como por la posibilidad de reconstruir, en parte, el modo en que ingresa la corriente ilustrada en la filosofía europea de mediados y segunda mitad del siglo XIX.
Palabras clave: Nietzsche-Ilustración-Experimento-Filosofía
Caminos hacia la alteridad. La comprensión del otro en las elaboraciones de Heidegger en torno a ‘Sein und Zeit’
Authors: Butierrez Luis Fernando 
Published: April 2020

El presente artículo aborda las consideraciones de la alteridad del otro en las elaboraciones tempranas de Heidegger. Entendidas como condición de posibilidad para un abordaje propio de las cuestiones éticas, aquí analizamos tensiones y limitaciones en la tematización del otro, con el objetivo de dar cuenta de la transición hacia una comprensión radical de la alteridad en sus trabajos posteriores a 1930, más allá de las limitaciones antropológicas y subjetivas de las elaboraciones de Husserl. Para dar cuenta de ello, en primer lugar, analizamos los tratamientos respectivos en la fenomenología de Husserl, poniendo énfasis en los límites de su enfoque. En segundo lugar, abordamos las elaboraciones en torno a la alteridad del otro en los trabajos de Heidegger, para dilucidar el carácter transicional de la comprensión de base, a partir de sus desplazamientos y limitaciones propias. Finalmente, circunscribimos su enfoque sobre las estructuras relacionales, destacando algunas discusiones sobre implicancias éticas. De este modo, nos proponemos dar cuenta del carácter fronterizo de una comprensión filosófica del otro, en su empuje hacia su radicalización en el pensamiento contemporáneo.
Study on clinical effects of pedicle screw combined with immobilized implantation bone by wirerope and hallow compression screw immobilization in treating spondylolysis of lumbar vertebra of multiple segments of adults
Authors: Zhao Dongdong , Li Feng , Wu Yao , Zhang Xiaoyan 
Published: April 2020

Objective: To observe clinical effects of pedicle screw fixation combined with cable wires and bone graft and cannulated compression screws on adult multi-segment lumbar spondylolysis.Methods: 70 cases of patients with multi-segment lumbar spondylolysis were selected in our hospital. According to different surgical schemes, these patients were divided into the observation group (35 cases) and the control group (35 cases). The observation group received pedicle screw fixation combined with cable wires and bone graft and the control group received cannulated compression screw fixation. Macnab criteria were adopted to implement a therapeutic evaluation of two groups of patients to make an observation and comparison of the excellent and good rate of surgery and a series of indicators including perioperative clinical effects, intraoperative blood loss, duration of surgery, hospital length of stay (HLOS), visual analogue scale (VAS), Oswestry disability index and Japanese Orthopaedic Association (JOA) score.Results: The excellent and good rate of the observation group was 97.14%, and that of the control group was 82.86%, the difference between two groups was statistically significant (χ2 = 6.248, p = .012). The differences in intraoperative blood loss, duration of surgery and HLOS between two groups were statistically significant (t = -4.55, t = -4.55, t = -4.55; p < .05). Oswestry index, VAS score and JOA score of the observation group were (2.4 ± 0.9), (28.5 ± 6.4) and (27.1 ± 3.1) respectively, and these of the control group were (3.5 ± 1.2), (37.1 ± 7.8) and (21.3 ± 2.7) respectively, the differences between two groups were statistically significant (t = 4.338, t = 5.043, t = 8.347, p < .05).Conclusions: Pedicle screw combined with immobilized implantation bone by wirerope has an excellent clinical effect on the treatment of adult multi-segment lumbar spondylolysis, and it has a series of advantages such as fast postoperative recovery, small surgical trauma and so on. In addition, this technique can also restore the stability of spinal segments and relieve pains to a greater degree.
Online Peer feedback
Authors: Møller Karen Louise , Løvschal Mette 
Published: April 2020

Peergrade er et digitalt redskab, der kan anvendes til at understøtte peer feedback aktiviteter. I denne artikel beskrives anvendelsen af redskabet i universitetsundervisning, nærmere betegnet i faget Forhistorisk Arkæologi II på Aarhus Universitet. Aktiviteterne var ikke obligatoriske, men de forbedrede portfolio-opgaver indgik i de studerendes individuelle eksamensportfolio, der blev afleveret forud for mundtlig eksamen i faget. Vi beskriver de studerendes oplevelser på baggrund af deres svar på spørgeskema og deltagelse i fokusgruppeinterview. Vi slutter af med anbefalinger for brug af peer feedback aktiviteter med Peergrade i universitetsundervisning.
Monitoring body condition score of reintroduced banteng (Bos javanicusD’Alton, 1923) into Salakphra Wildlife Sanctuary, Thailand
Authors: Kongsurakan Praeploy , Chaiyarat Rattanawat , Nakbun Seree , Thongthip Nikorn , Anuracpreeda Panat 
Published: April 2020

BackgroundBanteng (Bos javanicusd’Alton 1823) are an endangered species, highly sensitive to habitat structure and quality. In many areas, banteng were extinct and needed to be reintroduced to restore their population. Thus, understanding the responses of body condition of reintroduced banteng to their habitat was important for ensuring the sustainability of a reintroduction program. The aim of the present study was to evaluate the body condition of banteng after reintroduction into the Salakphra Wildlife Sanctuary in Thailand based on photographs from camera-traps carried out between July 2016 and November 2018.MethodsSeven banteng were bred at the Khao Nampu Nature and Wildlife Education Center and systematically reintroduced into the Salakphra Wildlife Sanctuary in December 2015 (four) and July 2016 (three). The seven reintroduced adults and two newborns (from the 2015 group) were captured via camera traps in 2018. The body condition scoring (BCS) obtained from these photographs was used to identify the individual performance of all seven adults after their reintroduction.ResultsThe BCS scores in reintroduced adult banteng, both males and females, (between 5 and 7 years old) increased significantly over time after reintroduction into a natural habitat (p< 0.05), although the BCS scores in females were not significantly different between the second and third years (p> 0.05).ConclusionsThe results from the present study suggest that camera traps are a practical tool to assess the BCS of reintroduced banteng, and can be used to monitor their condition post-release. These techniques may be appropriate for translocation programs elsewhere.
Bioprinting Neural Systems to Model Central Nervous System Diseases
Authors: Qiu Boning , Bessler Nils , Figler Kianti , Buchholz Maj‐Britt , Rios Anne C. , Malda Jos , Levato Riccardo , Caiazzo Massimiliano 
Published: April 2020

AbstractTo date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of neural systems. The search for valuable models of neurodegenerative diseases has recently been revived by the addition of 3D culture that allows to re‐create the in vivo microenvironment including the interactions among different neural cell types and the surrounding extracellular matrix (ECM) components. In this review, the new challenges in the field of CNS diseases in vitro 3D modeling are discussed, focusing on the implementation of bioprinting approaches enabling positional control on the generation of the 3D microenvironments. The focus is specifically on the choice of the optimal materials to simulate the ECM brain compartment and the biofabrication technologies needed to shape the cellular components within a microenvironment that significantly represents brain biochemical and biophysical parameters.
One‐Step Photoactivation of a Dual‐Functionalized Bioink as Cell Carrier and Cartilage‐Binding Glue for Chondral Regeneration
Authors: Lim Khoon S. , Abinzano Florencia , Bernal Paulina Nuñez , Albillos Sanchez Ane , Atienza‐Roca Pau , Otto Iris A. , Peiffer Quentin C. , Matsusaki Michiya , Woodfield Tim B. F. , Malda Jos , Levato Riccardo 
Published: April 2020

AbstractCartilage defects can result in pain, disability, and osteoarthritis. Hydrogels providing a chondroregeneration‐permissive environment are often mechanically weak and display poor lateral integration into the surrounding cartilage. This study develops a visible‐light responsive gelatin ink with enhanced interactions with the native tissue, and potential for intraoperative bioprinting. A dual‐functionalized tyramine and methacryloyl gelatin (GelMA‐Tyr) is synthesized. Photo‐crosslinking of both groups is triggered in a single photoexposure by cell‐compatible visible light in presence of tris(2,2′‐bipyridyl)dichlororuthenium(II) and sodium persulfate as initiators. Neo‐cartilage formation from embedded chondroprogenitor cells is demonstrated in vitro, and the hydrogel is successfully applied as bioink for extrusion‐printing. Visible light in situ crosslinking in cartilage defects results in no damage to the surrounding tissue, in contrast to the native chondrocyte death caused by UV light (365–400 nm range), commonly used in biofabrication. Tyramine‐binding to proteins in native cartilage leads to a 15‐fold increment in the adhesive strength of the bioglue compared to pristine GelMA. Enhanced adhesion is observed also when the ink is extruded as printable filaments into the defect. Visible‐light reactive GelMA‐Tyr bioinks can act as orthobiologic carriers for in situ cartilage repair, providing a permissive environment for chondrogenesis, and establishing safe lateral integration into chondral defects.
Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells
Authors: Maslanka Figueroa Sara , Fleischmann Daniel , Beck Sebastian , Tauber Philipp , Witzgall Ralph , Schweda Frank , Goepferich Achim 
Published: April 2020

AbstractPoor drug availability in the tissue of interest is a frequent cause of therapy failure. While nanotechnology has developed a plethora of nanocarriers for drug transport, their ability to unequivocally identify cells of interest remains moderate. Viruses are the ideal nanosized carriers as they are able to address their embedded nucleic acids with high specificity to their host cells. Here, it is reported that particles endowed with a virus‐like ability to identify cells by three consecutive checks have a superior ability to recognize mesangial cells (MCs) in vivo compared to conventional nanoparticles. Mimicking the initial viral attachment followed by a stepwise target cell recognition process leads to a 5‐ to 15‐fold higher accumulation in the kidney mesangium and extensive cell uptake compared to particles lacking one or both of the viral traits. These results highlight the relevance that the viral cell identification process has on specificity and its application on the targeting strategies of nanomaterials. More so, these findings pave the way for transporting drugs into the mesangium, a tissue that is pivotal in the development of diabetic nephropathy and for which currently no efficient pharmacotherapy exists.
Precision Delivery of Multiscale Payloads to Tissue‐Specific Targets in Plants
Authors: Cao Yunteng , Lim Eugene , Xu Menglong , Weng Jing‐Ke , Marelli Benedetto 
Published: April 2020

AbstractThe precise deployment of functional payloads to plant tissues is a new approach to help advance the fundamental understanding of plant biology and accelerate plant engineering. Here, the design of a silk‐based biomaterial is reported to fabricate a microneedle‐like device, dubbed “phytoinjector,” capable of delivering a variety of payloads ranging from small molecules to large proteins into specific loci of various plant tissues. It is shown that phytoinjector can be used to deliver payloads into plant vasculature to study material transport in xylem and phloem and to perform complex biochemical reactions in situ. In another application, it is demonstrated Agrobacterium‐mediated gene transfer to shoot apical meristem (SAM) and leaves at various stages of growth. Tuning of the material composition enables the fabrication of another device, dubbed “phytosampler,” which is used to precisely sample plant sap. The design of plant‐specific biomaterials to fabricate devices for drug delivery in planta opens new avenues to enhance plant resistance to biotic and abiotic stresses, provides new tools for diagnostics, and enables new opportunities in plant engineering.
Attributes, Fabrication, and Applications of Gallium‐Based Liquid Metal Particles
Authors: Lin Yiliang , Genzer Jan , Dickey Michael D. 
Published: April 2020

AbstractThis work discusses the attributes, fabrication methods, and applications of gallium‐based liquid metal particles. Gallium‐based liquid metals combine metallic and fluidic properties at room temperature. Unlike mercury, which is toxic and has a finite vapor pressure, gallium possesses low toxicity and effectively zero vapor pressure at room temperature, which makes it amenable to many applications. A variety of fabrication methods produce liquid metal particles with variable sizes, ranging from nm to mm (which is the upper limit set by the capillary length). The liquid nature of gallium enables fabrication methods—such as microfluidics and sonication—that are not possible with solid materials. Gallium‐based liquid metal particles possess several notable attributes, including a metal–metal oxide (liquid–solid) core–shell structure as well as the ability to self‐heal, merge, and change shape. They also have unusual phase behavior that depends on the size of the particles. The particles have no known commercial applications, but they show promise for drug delivery, soft electronics, microfluidics, catalysis, batteries, energy harvesting, and composites. Existing challenges and future opportunities are discussed herein.
Further delineation of Basel‐Vanagaite‐Smirin‐Yosef syndrome: Report of three patients
Authors: Haynes Devon , Pollack Lynda , Prasad Chitra , Goobie Sharan , Colaiacovo Samantha , Wolfinger Tara , Lacassie Yves 
Published: April 2020

AbstractBasel‐Vanagaite‐Smirin‐Yosef syndrome is a recently described autosomal recessive intellectual disability syndrome caused by variants in the MED25 gene. While it was originally identified in Brazil, it was further described in Israel by authors who are now the namesake of the condition. A 2018 publication further contributed to its delineation, but the patient's phenotype was complicated by a dual diagnosis. More recently, an article describing a set of affected siblings was published. We describe three, previously unreported, patients showing clinical variability for this newly defined syndrome. The major features determined by “reverse phenotyping” include significant to profound developmental delays/intellectual disability with absent or delayed speech, epilepsy, ocular abnormalities, cleft lip and/or palate, congenital heart disease, urogenital anomalies, skeletal abnormalities, brain malformations and/or microcephaly, failure to thrive, and dysmorphic features. The authors suggest the delineation of an acronym using the gene name and common features seen across the majority of patients reported so far. This new nomination, MED‐DOCS, may help clinicians to recognize, suspect, and remember this novel syndrome.
Effect of river size on Amazonian primate community structure: A biogeographic analysis using updated taxonomic assessments
Authors: Fordham Gail , Shanee Sam , Peck Mika 
Published: April 2020

AbstractThe mechanisms that underlie the diversification of Neotropical primates remain contested. One mechanism that has found support is the riverine barrier hypothesis (RBH), which postulates that large rivers impede gene flow between populations on opposite riverbanks and promote allopatric speciation. Ayres and Clutton‐Brock (1992) demonstrated that larger Amazonian rivers acted as barriers, delineating the distribution limits of primate species. However, profound changes in taxonomy and species concepts have led to the proliferation of Neotropical primate taxa, which may have reduced support for their results. Using the most recent taxonomic assessments and distribution maps, we tested the effect of increasing river size on the similarity of opposite riverbank primate communities in the Amazon. First, we conducted a literature review of primate taxonomy and developed a comprehensive spatial database, then applied geographical information system to query mapped primate ranges against the riverine geography of the Amazon watershed to produce a similarity index for opposite riverbank communities. Finally, we ran models to test how measures of river size predicted levels of similarity. We found that, almost without exception, similarity scores were lower than scores from Ayres and Clutton‐Brock (1992) for the same rivers. Our model showed a significant negative relationship between streamflow and similarity in all tests, and found river width significant for the segmented Amazon, but not for multiple Amazon watershed rivers. Our results support the RBH insofar as they provide evidence for the prediction that rivers with higher streamflow act as more substantial barriers to dispersal, and accordingly exhibit greater variation in community composition between riverbanks.
Sustainable Peptide Synthesis Enabled by a Transient Protecting Group
Authors: Knauer Sascha , Koch Niklas , Uth Christina , Meusinger Reinhard , Avrutina Olga , Kolmar Harald 
Published: April 2020

AbstractThe growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly from protected building blocks, and switching to water as a reaction medium remains a major hurdle in peptide chemistry. We report an aqueous solid‐phase peptide synthesis strategy that is based on a water‐compatible 2,7‐disulfo‐9‐fluorenylmethoxycarbonyl (Smoc) protecting group. This approach enables peptide assembly under aqueous conditions, real‐time monitoring of building block coupling, and efficient postsynthetic purification. The procedure for the synthesis of all natural and several non‐natural Smoc‐protected amino acids is described, as well as the assembly of 22 peptide sequences and the fundamental issues of SPPS, including the protecting group strategy, coupling and cleavage efficiency, stability under aqueous conditions, and crucial side reactions.