bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planform and stratigraphic signature of proximal braided streams: remote-sensing and ground-penetrating-radar analysis of the Kicking Horse River, Canadian Rocky Mountains
Authors: Cyples Natasha N. , Ielpi Alessandro , Dirszowsky Randy W. 
Published: January 2020

ABSTRACTBraided rivers have accumulated a dominant fraction of the terrestrial sedimentary record, and yet their morphodynamics in proximal intermountain reaches are still not fully documented—a shortcoming that hampers a full understanding of sediment fluxes and stratigraphic preservation in proximal-basin tracts. Located in the eastern Canadian Cordillera near the continental divide, the Kicking Horse River is an iconic stream that has served as a model for proximal-braided rivers since the 1970s. Legacy work on the river was based solely on ground observations of small, in-channel bars; here we integrate field data at the scale of individual bars to the entire channel belt with time-lapse remote sensing and ground-penetrating-radar (GPR) imaging, in order to produce a more sophisticated morphodynamic model for the river.Cyclical discharge fluctuations related to both diurnal and seasonal variations in melt-water influx control the planform evolution and corresponding stratigraphic signature of trunk channels, intermittently active anabranch channels, and both bank-attached and mid-channel bars. Three-dimensional GPR fence diagrams of compound-bar complexes are built based on the identification of distinct radar facies related to: i) accretion and migration of unit bars, ii) both downstream and lateral outbuilding of bar-slip foresets; iii) buildup of bedload sheets, iv) channel avulsion, and v) accretion of mounded bars around logs or outsized clasts. Trends observed downstream-ward include decreases in gradient and grain size decreases, trunk-channel shrinkage, intensified avulsion (with increase in abundance for anabranch channels), and a shift from high-relief to low-relief bar topography. The integration of ground sedimentology, time-lapse remote sensing, and GPR imaging demonstrates that proximal-braided streams such as the Kicking Horse River can be critically compared to larger systems located farther away from their source uplands despite obvious scale differences.
Gestión del talento humano y rentabilidad del sector hotelero de la región de Puno
Authors: Flores-Quispe Ludwing Roald 
Published: January 2020

Rev.esc.adm.neg
El artículo tiene como objetivo analizar la incidencia de la gestión del talento humano en la rentabilidad económica y financiera de las organizaciones del sector hotelero, el estudio es de naturaleza cuantitativa y de diseño no experimental, puesto que se analizaron las variables sin la manipulación deliberada, observando los fenómenos tal como se presentan en su contexto natural. Esta investigación se realizó en la región Puno, Perú, dado que la hotelería es una de las principales actividades de esta región. De esta investigación se concluye que la gestión de personas es un área sensible y prioritaria en las organizaciones del sector hotelero, relevante en el alcance de las metas y objetivos institucionales, constituyéndose así como un eje que repercute y que es altamente significativo respecto a la rentabilidad económica. Se analizaron seis dimensiones de la gestión del talento humano y de ellas las que presentaron la más alta relación respecto a la rentabilidad fueron la admisión y la compensación . Se evidenció que las empresas del sector hotelero no están siendo lo suficientemente eficientes y se enfrentan al gran reto de la consolidación de sus procesos, aspecto en el que el personal se convierte en el elemento básico de la superación de la empresa, ya que coadyuva a la organización a ganar y mantener una ventaja sostenible. A lo largo del estudio se demostró que el éxito empresarial depende más de la adecuada gestión del talento humano y no tanto de los recursos financieros ni activos fijos como se considera generalmente.
Subsurface Sludge Sequestration in Cyclic Steam Stimulated Heavy-Oil Reservoir in Liaohe Oil Field
Authors: Zhong Liguo , Liu Jianbin , Yuan Xiaonan , Wang Cheng , Teng Liyong , Zhang Shoujun , Wu Fei , Shen Wenmin , Jiang Cheng 
Published: January 2020

Summary
There are a lot of sludges produced in oil production and storage processes in Liaohe Oil Field. Usually complicated chemical processes are involved in treating the sludge effectively and such surface-treatment processes are subject to high cost and environmental challenges. Therefore, the feasibility and performance of sludge injection into steam-stimulated wells, and sludge sequestration and associated heavy-oil-recovery improvement are investigated on the basis of results of laboratory research and field operation.
The sludge originally produced from the reservoir comprises mainly water, some oil components, and solid phase such as mud and fine sand, and aggregation of the injected sludge components, except water, could block the void porous space. Actually, the sludge is buried into its origin, the reservoir. As the sludge is injected into the steamed reservoir through an enlarged pore at high injection pressure, the permeability of the formation could be significantly decreased (the permeability reduction rate could be more than 98% after sludge blocking in our experiments with sandpacked tubes), and the sludge blocking performance is related to the reactions of oil and solid separated from the sludge, including adherence to the sand surface, consolidation of the sands, and filling in the void porous space. Consequently, the sludge is stored in the steamed formation, and the water in the sludge is separated and produced. At the same time, steam conformance and heating efficiency could be improved by implementing a sludge blocking process, thereby significantly improving oil production.
Sludge sequestration has been applied to 45 steamed wells in Shuguang Oilfield until 2018, and all the wells have been stimulated by 7–10 cycles of CSS process. The total sludge injection of the wells is up to 133,200 tons, and more than 15,000 tons of oil and solid separated from the sludge are deposited underground. At the same time, more than 20% increase in cyclic oil production on average is obtained by the sludge-injection process.
A method for obtaining flexible broccoli varieties for sustainable agriculture
Authors: Ciancaleoni Simona , Negri Valeria 
Published: January 2020

Abstract
Background The use of high inputs in agriculture resulted in few varieties (hybrids and pure lines) used in all agricultural systems. Also varieties of vegetables, including broccoli ( Brassica oleracea L. spp. capitata L. (DC.) convar. botrytis (L.) Alef. var. italica Plenck), for organic and low-input agriculture, are almost exclusively hybrids, since there are very few specific breeding programs and varieties for sustainable agriculture systems. A strategy to overcome this issue is the adoption of specific breeding programs for developing heterogeneous varieties (i.e. synthetics, open pollinated varieties, composite cross populations and mixtures). In fact, heterogeneous varieties are able to evolve and adapt to specific agro-climatic conditions. The aim of this study was to develop a method (an Evolutionary Breeding Program, EBP) for obtaining heterogeneous varieties and test its efficiency in developing highly diverse varieties, as needed in sustainable agriculture. A synthetic variety originated from a landrace was multiplied in different environments for 3 cycles and morpho-phenological and genetic diversity of the derived populations were assessed. Results The presented results are the first and unique indication about the efficiency of a short-time EBP for an allogamous species like broccoli. Few morphological changes were observed among varieties multiplied in different environments with different agro-climatic conditions. This could be probably due to the initial genetic diversity of the landrace from which the populations were selected and also to the great plasticity of the crop. However, SSR data highlighted a genetic differentiation among populations multiplied for two/three years across Europe and in Central Italy, that was not so evident when considering morphological data only. Conclusions Few years of multiplication in different environments resulted in genetically differentiated broccoli populations that nonetheless preserved the original genetic diversity and productivity level and appear to evolve in relationship to different environments: the applied EBP is useful for developing heterogeneous materials for sustainable agriculture.
Low Proportion of Women who came knowing their HIV Status at First Antenatal Care Visit, Uganda, 2012-2016: A Descriptive Analysis of Surveillance Data
Authors: Nakanwagi Miriam , Bulage Lilian , Kwesiga Benon , Ario Alex Riolexus , Birungi Doreen Agasha , Lukabwe Ivan , Matovu John Bosco , Taasi Geoffrey , Nabitaka Linda , Mugerwa Shaban , Musinguzi Joshua 
Published: January 2020

Abstract
Background: HIV testing is the cornerstone for HIV care and support services, including Prevention of Mother to Child Transmission of HIV (PMTCT). Knowledge of HIV status is associated with better reproductive health choices and outcomes for the infant’s HIV status. We analyzed trends in known current HIV status among pregnant women attending the first antenatal care (ANC) visit in Uganda, 2012-2016. Methods: We conducted secondary data analysis using District Health Information Software2 data on all pregnant women who came for ANC visit during 2012-2016. Women who brought documented HIV negative test result within the previous four weeks at the first ANC visit or an HIV positive test result and/or own HIV care card were considered as knowing their HIV status. We calculated proportions of women with known current HIV status at first ANC visit, and described linear trends both nationally and regionally. We tested statistical significance of the trend using modified Poisson regression with generalized linear models. For known HIV positive status, we only analyzed data for years 2015-2016 because this is when this data became available. Results: There was no significant difference in the number of women that attended first ANC visits over years 2012-2016. The proportion of women that came with known HIV status increased from 4.4% in 2012 to 6.9% in 2016 and this increase was statistically significant (p<0.001). Most regions had an increase in trend except the West Nile and Mid-Eastern (p<0.001). The proportion of women that came knowing their HIV positive status at first ANC visit was slightly higher than that of women that were newly tested HIV positive at first ANC visit in 2015 and 2016. Conclusion: Although the gap in women that come at first ANC visit without knowing their HIV positive status might be reducing, a large proportion of women who were infected with HIV did not know their status before the first ANC visit indicating a major public health gap. We recommend advocacy for early ANC attendance and hence timely HIV testing and innovations to promptly identify HIV positive women of reproductive age so that timely PMTCT interventions can be made.
PS4DR: A multimodal workflow for identification and prioritization of drugs based on pathway signatures
Authors: Emon Mhammad Asif , Domingo-Fernández Daniel , Hoyt Charles Tapley , Hofmann-Apitius Martin 
Published: January 2020

Abstract
Background: During the last decade, there has been a surge towards computational drug repositioning owing to constantly increasing -omics data in the biomedical research field. While numerous existing methods focus on the integration of heterogeneous data to propose candidate drugs, it is still challenging to substantiate their results with mechanistic insights of these candidate drugs. Therefore, there is a need for more innovative and efficient methods which can enable better integration of data and knowledge for drug repositioning.Results: Here, we present a customizable workflow (PS4DR) which not only integrates high-throughput data such as genome-wide association study (GWAS) data and gene expression signatures from disease and drug perturbations but also takes pathway knowledge into consideration to predict drug candidates for repositioning. We have collected and integrated publicly available GWAS data and gene expression signatures for several diseases and hundreds of FDA-approved drugs or those under clinical trial in this study. Additionally, different pathway databases were used for mechanistic knowledge integration in the workflow. Using this systematic consolidation of data and knowledge, the workflow computes pathway signatures that assist in the prediction of new indications for approved and investigational drugs. Conclusion: We showcase PS4DR with applications demonstrating how this tool can be used for repositioning and identifying new drugs as well as proposing drugs that can simulate disease dysregulations. We were able to validate our workflow by demonstrating its capability to predict FDA-approved drugs for their known indications for several diseases. Further, PS4DR returned many potential drug candidates for repositioning that were backed up by epidemiological evidence extracted from scientific literature. Source code is freely available at https://github.com/ps4dr/ps4dr.
Seroprevalence of Brucella Infection and Associated Factors among Pregnant Women Receiving Antenatal Care around Human, Wildlife and Livestock Interface in Ngorongoro Ecosystem, Northern Tanzania. A Cross Sectional Study
Authors: Makala Robert , Majigo Mtebe Venance , Bwire George M. , Kibwana Upendo , Mirambo Mariam M. , Joachim Agricola 
Published: January 2020

Abstract
Background
Brucellosis is a zoonotic disease transmitted to humans through contact with infected animals, animal products or consumption of infected dairy products. Brucella infection during pregnancy is of special interest due to association with adverse pregnancy outcomes. This study determined the seroprevalence and factors associated with Brucella infection among pregnant women around the human-wildlife-livestock interface area in Ngorongoro Ecosystem, Northern Tanzania.
Methods
A facility-based cross-sectional study was conducted between May and June 2018 at six health facilities that provide antenatal services. Pregnant women receiving antenatal care were invited to participate. A structured questionnaire was used to collect socio-demographic and obstetric characteristics in addition to behavior and practices related to the occurrence of human brucellosis. The presence of serum immunoglobulin against Brucella was determined using Rose Bengal Plate Test (RBPT). The positive samples were further assayed for the presence of IgG and IgM using Enzyme-Linked Immunosorbent assay. Bivariate analysis was conducted to determine the variables associated with Brucella seropositivity. Multivariable logistic regression analysis was performed to examine the factors independently associations with Brucella seropositivity after adjustment for other explanatory variables.
Results
A total of 313 participants were enrolled in the study. The overall seroprevalence of Brucella infection was 10.9 % (34/313) determined by Rose Bengal plate test. Of 34 positive individuals, 27(79.4%) and 8(23.5%) were positive in the ELISA specific for IgG and IgM Brucella antibodies respectively. Regular contact with manure (AOR 3.16, 95%CI 1.27-7.83) and preference for animal fresh milk (AOR 3.80, 95 % CI 1.23–11.69), raw meat (AOR 2.58, 95 % CI 1.14 – 5.81) and raw animal blood (AOR 2.71, 95 % CI 1.15–6.35) increased the odds of being Brucella seropositive . Contact with the animal placenta were not associated with Brucella seropositivity after adjustment.
Conclusion
This study has found that brucellosis is an important public health problem among pregnant women in areas with interactions of humans; livestock and wildlife. The risk of infection increased with the regular contact with manure and preference of raw foodstuffs like animal blood, meat, and milk. We emphasize the need for interventional strategies to reduce the risk of exposure.
Pedicle frozen autograft-prosthesis composite reconstructions for malignant bone tumors of the proximal femur
Authors: xu gang , Miwa Shinji , Yamamoto Norio , Hayashi Katsuhiro , Takeuchi Akihiko , Igarashi Kentaro , Taniguchi Yuta , Araki Yoshihiro , Yonezawa Hirotaka , Morinaga Sei , Tsuchiya Hiroyuki 
Published: January 2020

Abstract
Background
Limb salvage surgery is becoming increasingly popular after tumor resection in the lower extremity. Biological reconstruction and use of megaprosthesis are main methods for malignant bone tumors of the proximal femur, which remain controversial due to short- and long-term complication in the proximal femur. Tumor-bearing bone treated by liquid nitrogen is one of biological reconstruction. This study aimed to evaluate the mid- and long-term functional outcomes and complications in patients treated with frozen autograft–prosthesis composite (FAPC) reconstructions in the proximal femur.
Methods
This retrospective study included 19 patients (10 women, 9 men) with malignant tumors of the proximal femur who underwent tumor-wide resection and FAPC reconstruction (mean age, 46 years; range, 9-77 years). The mean follow-up period of 69 months (range, 9-179 month). Functional outcomes, oncological outcomes and complications were evaluated by Musculoskeletal Tumor Society score, clinical and radiological examinations.
Results The overall survival rate was 68.4%, and the mean Musculoskeletal Tumor Society functional score was 26.4 points (88%). FAPC survival rates were 100% and 50% at 5 and 10 years, respectively. Five of the 19 patients (26%) had complications: 2 required prosthesis removal and 2 developed a deep infection around acetabular. Wear of the acetabulum occurred in 2 cases, while disease recurrence was occurred in 1 case. There were no cases of greater trochanter avulsion, obvious absorption around frozen bone, prosthesis loosening or leg length discrepancy.
Conclusions
Due to without femoral osteotomy, this technique features satisfactory functional outcome and provide biomechanical stability that is comparable to those of other methods of biological reconstruction or megaprosthesis.
A cross-sectional study of the relationships between different components of sarcopenia and brachial ankle pulse wave velocity in community-dwelling elderly
Authors: Rong Yu-Dong , Bian Ai-Lin , Hu Hui-Ying , Ma Yue , Zhou Xin-Zi 
Published: January 2020

Abstract
Background
Declination of skeletal muscle mass or sarcopenia is associated with the arterial stiffness. However, but it is unclear whether muscle strength and physical performance; important contributors of sarcopenia are associated with the arterial stiffness. The aim of this study was to investigate the relationship between sarcopenia, the components of sarcopenia and arterial stiffness among elderly population.
Methods
Four hundred and fifty community dwelling elderly participants (266 male, and 184 female, >65 years) were enrolled in this study. Each participant received general medical examinations in Tianjin First Center Hospital. Based on the diagnostic criteria for sarcopenia in older people developed by the Asian Working Group for Sarcopenia (AWGS), 89 participants were separated into the sarcopenia group. The living habits, disease status, general status and laboratory examinations of all participants were collected. The body composition (including appendicular skeletal muscle mass , and visceral fat area (VFA) was measured by bioimpedance analysis. Handgrip strength (HS), usual gait speed (GS), and brachial ankle pulse wave velocity (baPWV) were measured.
Results
Sarcopenia participants had higher baPWV, nutrition risk and lower appendicular skeletal muscle index(ASMI), HS, GS, body mass index(BMI), triacylglycerol(TG), serum albumin(ALB) and creatinine(Cr) than the non-sarcopenia participants; Sarcopenia participants also had higher visceral fat area (VFA)compared to non-sarcopenia participants (p<0.05). ASMI and HS were negatively associated with baPWV (t=-5.807, p=0.000 and t=-3.085, p=0.002), but the relationship between baPWV, and GS was not statistically significant (t=-0.862, p=0.389) by multivariable linear regression. After adjusting for confounders, a multivariate logistic regression analysis revealed that sarcopenia was related to age, BMI, sports and baPWV in community dwelling elderly.
Conclusions
ASMI and HS were negatively associated with baPWV in community dwelling elderly in China; and baPWV was a risk factor of sarcopenia.
Cross-cultural adaptation and validation of the Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR)
Authors: Florescu Sorin , Vermesan Dinu , Haragus Horia , Patrascu Jenel M , Timar Bogdan , Todor Adrian 
Published: January 2020

Abstract
Aim: To perform validation of the Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR).
Method: 96 patients (101 knees) with advanced osteoarthritis (OA) scheduled for total knee replacement completed Romanian translations of KOOSJR and IKDC (International Knee Documentation Committee – subjective knee form) and Euroqol EQ-5D-5L, and the treating physician completed the original knee society score (KSS).
Results: Average age was 66.4 (range 50-83) years and male to female ratio 1:3.76. There was moderate correlation between the test-retest (average 4 days) KOOSJR (r=0.618, n=45) and IKDC (r=-0.671, n=99), weak between KOOSJR and EQ-5D-5L Index (r=-0.431, n=100) and VAS (r=-0.364, n=99) and very weak to KSS score (r=-0.133, n=98) and function (r=-0.072, n=97) For the first KOOSJR, Cronbach's alpha was 0.816 and intraclass correlation coefficient (ICC) 0.816 (95% CI 0.755-0.866) for average measures. For the retest, Cronbach's alpha was 0.841 (95% CI 0.760-0.903) for averages.
Conclusion: The Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR) is a valid, reliable, consistent and reproducible clinical score for patients with OA requiring arthroplasty.
Immune activation of murine RAW264.7 macrophages by sonicated and alkalized paramylon from Euglena gracilis
Authors: Guo Qingqing , Bi Decheng , Wu Mingcan , Yu Boming , Hu Lang , Liu Chenchen , Gu Liang , Zhu Hui , Lei Anping , Xu Xu , Wang Jiangxin 
Published: January 2020

Abstract
Background: Euglena is a new super health food resource that is rich in the natural polysaccharide paramylon, a linear β-1,3-glucan with various biological activities including activity on the immune system in different cell lines and animals. Despite these reports, the immune regulation mechanism of paramylon is still unclear.
Results: We investigate the signaling pathways paramylon impacts in immune macrophages. In RAW264.7 macrophages, sonicated and alkalized paramylon oligomers up-regulated inducible nitric oxide synthase (iNOS) and increased secretion of nitric oxide (NO) , interleukin (IL)-6 and tumor necrosis factor (TNF)- α, in a concentration-dependent manner. In addition, paramylon activated the nuclear factor-κB(NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways and inhibiting these pathways attenuated the paramylon-induced secretion of the above immune-mediators.
Conclusions: These results demonstrate that Euglena gracilis paramylon modulates the immune system via activation of the NF-κB and MAPK signaling pathways and thus has potential therapeutic benefits.