bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuronal Ceroid Lipofuscinosis in a Domestic Cat Associated with a DNA Sequence Variant That Creates a Premature Stop Codon inCLN6
Authors: Katz Martin L , Buckley Reuben M , Biegen Vanessa , O’Brien Dennis P , Johnson Gayle C , Warren Wesley C , Lyons Leslie A 
Published: June 2020

AbstractA neutered male domestic medium-haired cat presented at a veterinary neurology clinic at 20 months of age due to progressive neurological signs that included visual impairment, focal myoclonus, and frequent severe generalized seizures that were refractory to treatment with phenobarbital. Magnetic resonance imaging revealed diffuse global brain atrophy. Due to the severity and frequency of its seizures, the cat was euthanized at 22 months of age. Microscopic examination of the cerebellum, cerebral cortex and brainstem revealed pronounced intracellular accumulations of autofluorescent storage material and inflammation in all 3 brain regions. Ultrastructural examination of the storage material indicated that it consisted almost completely of tightly-packed membrane-like material. The clinical signs and neuropathology strongly suggested that the cat suffered from a form of neuronal ceroid lipofuscinosis (NCL). Whole exome sequence analysis was performed on genomic DNA from the affected cat. Comparison of the sequence data to whole exome sequence data from 39 unaffected cats and whole genome sequence data from an additional 195 unaffected cats revealed a homozygous variant in CLN6 that was unique to the affected cat. This variant was predicted to cause a stop gain in the transcript due to a guanine to adenine transition (ENSFCAT00000025909:c.668G &gt; A; XM_003987007.5:c.668G &gt; A) and was the sole loss of function variant detected. CLN6 variants in other species, including humans, dogs, and sheep, are associated with the CLN6 form of NCL. Based on the affected cat’s clinical signs, neuropathology and molecular genetic analysis, we conclude that the cat’s disorder resulted from the loss of function of CLN6. This study is only the second to identify the molecular genetic basis of a feline NCL. Other cats exhibiting similar signs can now be screened for the CLN6 variant. This could lead to establishment of a feline model of CLN6 disease that could be used in therapeutic intervention studies.
Frecuencia de anticuerpos contra Hantavirus en agricultores de arroz de una región tropical en el noreste del Perú
Authors: Romaní Romaní Franco , García Mendoza Maria Paquita , Alarcón Villaverde Jorge Odón 
Published: June 2020

Introducción. Existe limitada evidencia acerca de la exposición al hantavirus en el Perú. Los casos sintomáticos y estudios de seroprevalencia en febriles y población asintomática provienen de la región Loreto; sin embargo, existen grupos ocupacionales expuestos a los reservorios en regiones sin circulación conocida del virus. Objetivo. Determinar la frecuencia de anticuerpos contra el hantavirus en arroceros de un valle ubicado en una zona subtropical del Perú. Métodos. Estudio transversal en una muestra aleatoria de 250 agricultores de arroz obtenida en 2010 en el valle Alto Mayo (región San Martín), que incluyó la obtención de una muestra de sangre en cuyo suero se determinó la presencia de anticuerpos inmunoglobulinas G (IgG) mediante ELISA indirecto, y anticuerpos inmunoglobulinas M (IgM) mediante ELISA de captura. Resultados. Identificamos un caso con anticuerpos IgM (0,40%, IC95%: 0,01 a 2,21), pero no encontramos agricultores con anticuerpos IgG. El caso tenía contacto frecuente con ratas y roedores en la vivienda y campo de cultivo. Conclusión. Mostramos la primera evidencia serológica de infección por hantavirus en la región San Martín.
COVID-19: En este momento podría ser útil el tratamiento antiviral en casos leves
Authors: Ticona Chávez Eduardo , Saavedra Leveau Carlos , Ticona Huaroto César , Hidalgo García Arquímedes 
Published: June 2020

La letalidad por COVID-19 así como su rápida diseminación son responsables de la actual crisis mundial; por ello, desde un inicio se buscaron medicamentos con acción antiviral frente a este agente. Es imposible, por ahora, saber qué persona en estado leve desarrollará una elevada carga viral o tiene una predisposición a desarrollar una respuesta extremada del sistema inmune, pero un tratamiento temprano en los casos leves no sólo garantizaría una mayor eficacia, sino que se evitarían los casos severos. En la actualidad no se dispone de ensayos clínicos, doble ciego, aleatroizados, ni metaanálisis para tomar decisiones seguras; mientras tanto, la pandemia avanza en nuestro país, generando dolor y muerte. En este contexto, en el Perú, las sociedades científicas han manifestado la necesidad del uso de medicamentos antivirales, aún con poca evidencia, basado en la probabilidad de éxito previo a un tratamiento, por sus efectos in vitro y por sus efectos clínicos tempranos, tales como: cloroquina, hidroxicloroquina, azitromicina, lopinavir, ritonavir. De esta manera, en el país desde el 29 de marzo de 2020, se dispone de una norma técnica del Ministerio de Salud, que facilita el uso de estos a nivel nacional para los casos moderados y severos. Consideramos que bajo un sistema estructurado, los centros de primer nivel de atención podrían tratar los casos leves de COVID-19. Nuestro país, a través de las estrategias de prevención y control de TB y de ITS/VIH/SIDA, tiene experiencia en el manejo de programas de tratamiento en dicho nivel. Los costos serán menores que los requeridos en el fortalecimiento del tercer nivel de atención.
Quimioterapia metronómica en pacientes con cáncer de mama metastásico
Authors: Soriano-Lorenzo Jorge , Soriano García Jorge , Lima Pérez Mayte 
Published: June 2020

La quimioterapia metronómica es un tipo de quimioterapia cuya toxicidad es mínima. Consiste en administrar agentes antineoplásicos habituales a intervalos muy próximos uno del otro y a dosis relativamente bajas durante un tiempo prolongado y sin periodos de descanso farmacológico. Esta terapia reduce la toxicidad y elimina la necesidad de tratamientos de soporte, por lo tanto, el empleo de esta modalidad de tratamiento en pacientes con enfermedad metastásica resulta de gran interés. Muchas investigaciones han evaluado la administración de medicamentos antineoplásicos en esquemas metronómicos, tanto en monoterapia como en combinación. Los fármacos mayormente estudiados son la ciclofosfamida, vinorelbina y capecitabina. Diversos estudios han mostrado la eficacia y tolerancia de esta terapia combinada con la hormonoterapia e inmunoterapia. Es necesaria mayor evidencia científica para definir cuestiones como: pacientes que más beneficio puedan obtener y las combinaciones terapéuticas a emplear de acuerdo al tipo de paciente.
IKTISYÂF AL-ISTI’ÂRAH FÎ YÂSÎN FADHÎLAH MIN DHAU NAZHARIYYAH ABD AL-QAHIR AL-JURJANI
Authors: Herdiansyah Pradibyo , Basid Abdul 
Published: June 2020

This study aims to reveal; 1) the structure and characteristics of the style of Isti'ârah (metaphor), 2) causes of beauty and implications of using Isti'ârah on meaning in Yâsîn Fadhîlah based on the theoretical perspective of Abd al-Qahir al-Jurjani. Researchers use descriptive qualitative research method by narrating the analysis of the object of study. The results showed some types of structure of Isti'arah al-Jurjani in verse and Yasin Fadhilah prayer, namely Isti'ârah which gives meaning benefit, Isti'ârah in verbs and nouns, Isti'ârah which similar form similarity, Isti'ârah whose form of similarity in the form of the meaning of nature, and Isti'ârah whose form of similarity is taken from the sensory and non-sensory delusion. The characteristics of Isti'ârah in Yâsîn Fadhîlah is the appointment of short, concise, hyperbolic style in showing the greatness of God as well as the conditions and torture of the unbelievers.
TAHLÎL MULÂIMAH BUNÛD IKHTIBÂR AL-LUGHAH AL-‘ARABIYYAH AL-NIHÂÎ AL-WATHANÎ LI MANHAJ MUSTAWÂ AL-WAHDAH AL-TA’LÎMIYYAH (KTSP) WA TASHNÎF BLOOM AL-MU’ADDAL
Authors: Bahruddin Uril , Qodri Muhammad 
Published: June 2020

This study aims to describe the suitability of Arabic language question item with educational unit level curriculum (KTSP) and Bloom’s taxonomy at the Final National Standard Madrasah (UAMBN) at Senior High School. This study used a qualitative approach with a descriptive type. Data was collected from exam documents on 2009/2010 and analysed using Krippendorff’s theory of content analysis . The findings of this study are (1) question items of Arabic language test of UAMBN academic year 2011/2012 for Senior High School level is suitable with Education Unit Level Curriculum in which the question items include: a) language element, and language skill (question items of reading and writing skills) that suitable with standard competency and basic competency. However, those question items are not including question items of phonetic and question items of listening and speaking skills. b) the suitable theme represented in each Standard Competency and Basic Competency from the first grade to third grade. (2) there is a correspondence between items of question that have met LOTS, MOTS and some HOTS.
ON THE TYPOLOGY OF THE NEGATION MARKER MÂ IN MODERN ARABIC DIALECTS: KUWAITI, JORDANIAN, SUDANESE, AND YEMENI
Authors: Al-Rawafi Abdulkhaleq Ali , Pujiati Tri , Sudana Dadang 
Published: June 2020

Modern Arabic Dialects (MADs) have an identical morphological system with some similarities and differences in the choice of the negation morphemes. The main concern of this paper is to discuss the typological properties of the negation morpheme mâ- ما and its variation in four Modern Arabic Dialects (MADs), JA (Jordanian Arabic), KA (Kuwaiti Arabic), SA (Sudanese Arabic), and YA (Yemeni Arabic) taking into account two negation strategies identified by Brustad (2000), namely Verbal Negation and Predicate Negation. Specifically, the study will shed light on the types and positions of the negation morphemes regarding VN and PN strategies. The study employed a descriptive-analytical approach. The data were taken from previous studies on negation in MADs and online sources, i.e., published articles and YouTube. The study found that when the negation morpheme mâ - ما is used as a one-negation system or a two-negation system, as a verbal and predicate negation, it changes to the negation morpheme mâ- ما due to phonological conditions and its pre-verbal position. The study concluded that three negation templates might be generalized in the four dialects, namely one-morpheme template, two-morpheme-template, and predicate negation template. Moreover, blocking of the negation morpheme movement in the sentences happens to do to phonological conditions.
Comprehensive chromatographic profiling of cannabis from 23 USA States marketed for medical purposes
Authors: Al Bakain Ramia Z. , Al-Degs Yahya S. , Cizdziel James V. , Elsohly Mahmoud A. 
Published: June 2020

AbstractIn this research, cannabis varieties represent 23 USA States were assayed by GC-FID to generate their complex chemical profiles informative for plants clustering. Results showed that 45 cannabinoids and terpenoids were quantified in all plant samples, where 8 cannabinoids and 18 terpenoids were identified. Among organics, Δ9-THC, CBN (cannabinoids) and Fenchol (terpenoid) not only showed the highest levels overall contents, but also were the most important compounds for cannabis clustering. Among States, Washington, Oregon, California and Hawaii have the highest cannabis content. GC-FID data were subjected to PCA and HCA to find (1) the variations among cannabis chemical profiles as a result of growing environment, (2) to reveal the compounds that were responsible for grouping cultivars between clusters and (3) finally, to facilitate the future profile prediction and States clustering of unknown cannabis based on the chemical profile. The 23 cannabis USA States were grouped into three clusters based on only Δ9-THC, CBN, C1 and Fenchol content. Cannabis classification based on GC-profile will meet the practical needs of cannabis applications in clinical research, industrial production, patients' self-production, and contribute to the standardization of commercially-available cannabis cultivars in USA.
Pemetrexed in Recurrent or Progressive Central Nervous System Lymphoma: A Phase I Multicenter Clinical Trial
Authors: Dietrich Jorg , Versmee Laura , Drappatz Jan , Eichler April F. , Nayak Lakshmi , Norden Andrew , Wong Eric , Pisapia Michelle R. , Jones SooAe S. , Gordon Amanda B. , Chabner Bruce A. , Hochberg Fred , Batchelor Tracy T. 
Published: June 2020

Abstract

Lessons Learned
The findings from this study using monotherapy with pemetrexed in a pretreated patient population are, overall, encouraging. Unlike high-dose methotrexate, which requires several days of inpatient hospitalization, pemetrexed is relatively easy to administer in the outpatient setting and remains a viable treatment option in this patient population. The maximum tolerated dose of pemetrexed administered (900 mg/m2 every 2 weeks) was generally well tolerated and showed activity in patients with relapsed or refractory CNSL.

Background
There is currently no standard salvage treatment for patients with relapsed/refractory central nervous system (CNS) lymphoma (CNSL). We report the results of a phase I study of pemetrexed, an antifolate drug with broader activity than methotrexate (MTX). We provide the safety, tolerability, and maximum tolerated dose (MTD) of pemetrexed in patients with recurrent CNSL.

Methods
Through October 2015, 17 patients with relapsed/refractory CNSL received pemetrexed every 2 weeks with the first cohort receiving 600 mg/m2 and dose escalation in increments of 300 mg/m2 to a maximum of 1,200 mg/m2. Three patients were to enroll at each dose level with expansion to six patients in the event of dose-limiting toxicity. Patients with both primary CNS lymphoma (PCNSL) and secondary CNS lymphoma (SCNSL) could be enrolled.

Results
Seventeen patients were evaluable with a median age of 63.7 years. Main adverse events included fatigue (82.4%), anemia (82.4%), and neutropenia (70.6%). The MTD was established at 900 mg/m2. Dose-limiting toxicities were recorded in one patient in the 600 mg/m2 cohort and in two patients in the 1,200 mg/m2 cohort. Fourteen patients were evaluable for response assessment; 21.4% achieved a complete response, 35.7% had a partial response, 14.3% had stable disease, and 28.6% had progressive disease. The median progression-free survival was 4.2 months. The median overall survival was 44.5 months.
In the original study protocol, the plan was to add an expansion cohort of six patients at MTD level. However, the first phase of the study was characterized by slow recruitment. Therefore, after achieving the primary objective of the study and establishing the MTD, the investigators decided to amend the protocol and to close the study.

Conclusion
Pemetrexed administered at 900 mg/m2 every 2 weeks exhibits single-agent activity in patients with recurrent CNSL; it is well tolerated, and side effects are manageable.
Estrategias del cooperativismo agrario frente a las transformaciones sociales y productivas recientes
Authors: Lopez-Castro Natalia 
Published: June 2020

Objetivo: El presente artículo analiza el modo en que las cooperativas agropecuarias de dos partidos del sudoeste de la provincia de Buenos Aires —Puán y Adolfo Alsina— enfrentaron el contexto de recurrentes crisis y retroceso general de este tipo de organizaciones económicas, que se registró en las últimas décadas en toda la región pampeana argentina.
Metodología: Con un enfoque metodológico cualitativo se estudian las diversas estrategias utilizadas por las entidades asociativas, entre los años 2002 y 2017 para lograr su permanencia y afianzamiento en los territorios; los factores que resultaron significativos en su delineación y las perspectivas a futuro.
Resultados: Se señalan las especificidades de las experiencias y sus puntos en común con lo ocurrido en entidades similares en otras zonas de la región.
Conclusiones: Las estrategias analizadas permiten reflexionar sobre las tensiones que se plantean entre el afianzamiento de un modelo económico productivo concentrado y las propuestas de la economía social; y, por otro, sobre las condiciones de posibilidad para repensar la organización social de la producción y los territorios en términos más diversos y democráticos.
Use of echocardiographic parameters of longitudinal mechanics to estimate diastolic function of systemic ventricle in patients after fontan operation
Authors: Sinelnikov Yu. S. , Matanovskaya T. V. , Orekhov S. A. 
Published: June 2020

Objective. To study the possibilities of using echocardiographic parameters of longitudinal mechanics to assess the diastolic function of the systemic ventricle (SV) in patients after Fontan operation.
Material and methods. We examined 29 children aged 8,6 3,16 years with a functionally single ventricle of the heart after performing a total cavopulmonary connection with fenestration of extracardiac conduit. By computed tomography there were evaluated: myocardial mass index (MMI) SV, ejection fraction (EF) SV, cardiac output (CO) SV, cardiac index (CI) SV. In addition to conventional echocardiographic (Echo) parameters, we also studied: diastolic velocity parameters of the longitudinal mechanics of the SV during the early rapid filling phase (SR E), in the phase of late diastolic filling (SR A), the ratio of the peaks of the strain rate (SR E/SR A), the stiffness index of a functionally single atrium, the atrial strain in conduit phase (AS cd), reservoir (ASr), and in the contractile phase (AS ct).
Results. Reduced values of the SI, CO and CI SV, an increase in MMI SV, normal values of EF SV. The parameters of the longitudinal diastolic strain rate in the early and late filling phases of e SV showed a direct significant correlation with SI, CO and CI SV and inverse correlation with E/e '. Parameters of longitudinal strain of the functionally single atrium in all phases were reduced, they all correlated with E / e, SR E / SR A, MMI SV, SI, CO and CI SV. There was no statistically significant relationship between the parameters of the longitudinal function of the atrium in all phases and atrial stiffness with sex and body surface area.
Conclusions. 1. The parameters of the longitudinal diastolic strain rate can be used to identify the diastolic dysfunction of the systemic ventricle in children after Fontan operation. 2. The hemodynamic parameters of the systemic ventricle (stroke index, cardiac output, cardiac index) determine the parameters of its diastolic mechanics. 3. The reservoir, conduit, and contractile atrial function in patients after total cavopulmonary connection are associated with both characteristics of diastolic longitudinal strain rate and hemodynamic parameters of systemic ventricle.
Seismic History of Central North Anatolian Region: New Contribution from Ottoman Archives
Authors: Şeşetyan Karin , Sakin Orhan , Sönmez Serpil , Demircioğlu Tümsa Mine Betül 
Published: June 2020

AbstractContemporary Ottoman sources bring a major contribution to the description of the seismic activity in the eastern Mediterranean region and are extensively used by historical seismologists. Among these, the documents of the Ottoman State Archives (Istanbul), and more specifically the correspondence of the local governors with the central authorities form a valuable source for the description of the earthquake effects in territories, which were under the Ottoman rule. Especially for the more recent periods, we observe that not only major earthquakes but also small-to-moderate-size events with local effects find their place in these documents. However, due to the complex and insufficiently categorized structure of the archival material, as well as the need for expertize in Ottoman language and history, except the sections covered in the works of N. Ambraseys and C. Finkel and a number of earthquake-specific studies, these documents are not yet fully exploited in the definition of the regional seismic history.In this pilot study, we investigate the Ottoman archive material related to earthquake effects in the central North Anatolian region and search for possible supportive or new contribution to the seismic history of the study area. The period of investigation is the nineteenth century, with occasional data also found for the pre and postperiod. The study revealed supportive information for 15 earthquakes that were already known to previous compilations, and data for 19 earthquakes that we categorize as new events, demonstrating the value of this primary source and the wealth of macroseismic information that can still be extracted, revealing earthquakes so far unknown as well as enriching the descriptive information related to already known ones.
Convalescent Plasma a Potential Therapy in Covid-19 Patients in Low Resource Setting: Rapid Review
Authors: Abdelmoneim Abdelrahman H. , Mustafa Mujahed I. , Abdalhaleem Adlan Raghda Hatim , Ahmed Abdulgader Noun Eltayeb , Osman Fadl Hiba Awadelkareem , Kamal Alhassan Nosaiba , G. Elbager Sahar 
Published: June 2020

Background: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the time of writing, neither a cure nor a vaccine has been approved by the World health organization (WHO) for this disease. Given the fact that the severe acute respiratory syndrome coronavirus (SARS) and Middle East Respiratory Syndrome (MERS) viruses have a genetic sequencing similar to SARS-CoV-2, and since the use of convalescent plasma therapy (CP) has proved its efficacy in SARS and MERS virus infections, researchers are starting to focus more on it as a possible therapy for the COVID-19 disease. The main objective of this rapid review is to report and summarize the published evidence on the role of convalescent plasma therapy in the current COVID-19 pandemic.
Method: The PICO method was used to establish the review question. Moreover, papers were gathered from PubMed and Google scholar, critically appraised for the best evidence. Piersons 5-component scheme was used to check the quality of the review papers.
Results: After website screening: 10 papers in PubMed and 6 papers from Google scholars were retrieved. There were encouraging reports regarding the uses of CP in the previous viral outbreaks likes SARS and Ebola, yet there is still a doubt on the efficacy of this mode of therapy in the current COVID-19 pandemic.
Conclusion: CP is a very promising treatment approach for COVID-19 patients; however, more clinical trials are required to validate the effectiveness of this therapy.
Keywords: COVID-19, convalescent plasma therapy, SARS-CoV-2, therapy.
Tumores del ovario
Authors: Pérez Gómez Eduardo , Parada R. Carlos , Duarte Contreras Alberto , Luzardo M. Luis Fernando 
Published: June 2020

Se hace un estudio de revisión de las neoplasias ováricas ocurridas en un lapso de 13 años en el Hospital San Juan de Dios, de Cúcuta. Se recopilaron 367 casos de los cuales 317 (86.9%) fueron benignos y 50 (13.1%) malignos. Las edades extremas oscilaron entre 3 y 90 años. Siguiendo la clasificación histogenética de Hertig y Gore, el tipo más frecuente de tumor fue el cistadenoma seroso, seguido de los quistes dermoides, cistadenocarcinoma y diversas clases de tumores. Se relievan la baja incidencia de tumores pseudomucinosos, la coexistencia de un cistadenocarcinoma papilar con un tumor de células granulosas, la asociación de un cistedon carcinoma seroso con embarazo y el hallazgo de un tumor de Brenner maligno. Se hace énfasis sobre el aumento de la incidencia del carcinoma ovárico, la baja tasa de supervivencia a los 5 años y la necesidad de medidas profilácticas para su detección temprana.
Tumores funcionales del ovario
Authors: Guzmán A. Rubén Darío , Fonnegra M. Alvaro , Alvarado P. Ricardo , Moreno Armando 
Published: June 2020

Se presentan 12 casos de tumores de la granulosa, teca-granulosa y te-comas manejados en 15 años.La edad de aparición entre 24 y 70 años; no se les diagnosticó pre-operatoriamente; generalmente unilaterales. Se revisan las diferentes teorías etiológicas; se comentan su Histología, su clínica y su tratamiento.