bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Colorectal and Endometrial Microsatellite Instability Tumor Analysis and Premm5 Risk Assessment for Predicting Pathogenic Germline Variants on Multigene Panel Testing
Authors: Mannucci Alessandro , Furniss C. Sloane , Ukaegbu Chinedu , Horiguchi Miki , Fehlmann Tara , Uno Hajime , Yurgelun Matthew B. , Syngal Sapna 
Published: September 2020

PURPOSE Tumor testing for microsatellite instability and/or mismatch repair-deficiency (MSI/IHC) and clinical prediction models effectively screen for Lynch syndrome (LS)–associated colorectal cancer (CRC) and endometrial cancer (EC), but they have not been assessed for their ability to identify non-LS forms of inherited risk. The aim of this study was to compare MSI/IHC and the PREMM5 prediction model to identify carriers of LS and non-LS pathogenic variants (PVs) among patients with CRC and EC. PATIENTS AND METHODS Data were retrospectively analyzed from two single-institution cohorts: 706 patients with CRC and/or EC referred for genetic evaluation/testing (high-risk cohort) and 1,058 consecutively ascertained patients with CRC (oncology clinic cohort), unselected for familial risk. All participants underwent germline multigene panel testing. PREMM5 scores were calculated from personal/family cancer history. The primary outcome was the proportion of individuals with germline PVs (LS PVs, high-penetrance PVs, and any PVs) who had abnormal MSI/IHC testing and/or PREMM5 score ≥ 2.5%. RESULTS MSI/IHC and PREMM5 had comparable sensitivity for identifying LS carriers in high-risk (89.3% v 85.7%; P = .712) and oncology clinic patients (96.6% v 96.6%; P = 1.000), although MSI/IHC had significantly superior specificity for LS (81.3% v 20.1%; P < .001; 92.3% v 24.3%; P < .001). In both cohorts, PREMM5 had superior sensitivity to MSI/IHC at identifying patients with any high-penetrance PVs and any low-, moderate-, and high-penetrance PVs. Among patients with normal MSI/IHC, PREMM5 identified 84.2% and 83.3% of high-risk patients with CRC/EC and oncology clinic CRC patients with high-penetrance PVs, respectively. CONCLUSION MSI/IHC and PREMM5 effectively identify patients with CRC and/or EC with LS, although MSI/IHC has better specificity for LS. Because PREMM5 identifies non-LS, high-penetrance germline PVs, patients with CRC and/or EC with PREMM5 score ≥ 2.5%, including those with normal MSI/IHC, should be offered multigene panel testing.
The effect of ionising radiation on the phenotype of bone marrow-derived extracellular vesicles
Authors: Kis Dávid , Persa Eszter , Szatmári Tünde , Antal Lilla , Bóta Attila , Csordás Ilona Barbara , Hargitai Rita , Jezsó Bálint , Kis Enikő , Mihály Judith , Sáfrány Géza , Varga Zoltán , Lumniczky Katalin 
Published: September 2020

Objectives:Ionising radiation-induced alterations affecting intercellular communication in the bone marrow (BM) contribute to the development of haematological pathologies. Extracellular vesicles (EVs), which are membrane-coated particles released by cells, have important roles in intercellular signalling in the BM. Our objective was to investigate the effects of ionising radiation on the phenotype of BM-derived EVs of total-body irradiated mice.Methods:CBA mice were irradiated with 0.1 Gy or 3 Gy X-rays. BM was isolated from the femur and tibia 24 h after irradiation. EVs were isolated from the BM supernatant. The phenotype of BM cells and EVs was analysed by flow cytometry.Results:The mean size of BM-derived EVs was below 300 nm and was not altered by ionising radiation. Their phenotype was very heterogeneous with EVs carrying either CD29 or CD44 integrins representing the major fraction. High-dose ionising radiation induced a strong rearrangement in the pool of BM-derived EVs which were markedly different from BM cell pool changes. The proportion of CD29 and CD44 integrin-harbouring EVs significantly decreased and the relative proportion of EVs with haematopoietic stem cell or lymphoid progenitor markers increased. Low-dose irradiation had limited effect on EV secretion.Conclusions:Ionising radiation induced selective changes in the secretion of EVs by the different BM cell subpopulations.Advances in knowledge:The novelty of the paper consists of performing a detailed phenotyping of BM-derived EVs after in vivo irradiation of mice.
Evaluation of cropping method for perennial ratoon rice: Adaptation of SALIBU to triple-cropping in Vietnam
Authors: Oda Masato , Nguyen Huu Chiem , Huynh Van Thao 
Published: September 2020

Background: Generally, the yield of ratoon rice is at most 50% of the main crop. However, a cropping method “SALIBU” achieved more yield than the main crop and enables the perennial cropping. Although the SALIBU method is implementing 10 additional management practices to conventional method in Indonesia, the effect of each management practice is unclear. Methodology: We evaluated the effect size using an L 16 orthogonal array design pot experiment in triple-cropping rice in Vietnam. The robustness was checked by duplicating the experiment under standard and poor conditions. Results and Discussion: Positive large effects were shown in the poor conditions only. Cutting twice most affected the number of ratoon tillers. Importantly, the effect was positive under poor conditions but negative under standard conditions. Late irrigation had a robust negative effect. No treatment is effective in the triple-cropping of standard conditions. The SALIBU includes practices with unstable, negative, or minimal effects. The unstable effects show the interaction with the condition. The practices that have negative effects should exclude. Using practice on small effect size should depend on a cost-benefit analysis. Conclusions: No additional practice is effective for changing the triple-cropping to perennial ratoon cropping except harvesting near the ground. However, further work will be conducted to clarify the interaction between cutting twice and the cultivation condition.
Przełożył Bruno Jasieński
Authors: Bednarczyk Anna 
Published: September 2020

Translated by Bruno Jasieński
The article discusses Bruno Jasieński’s translation of poems by Russian futurists. Attention is primarily drawn to the reproduction of typical features of futuristic poetry (non-standard words and images, neologisms, sound design of the text), and to the distinctive features of the creativity of the translated poets. As a result, the author comes to the conclusion that the most essential characteristic of the poet’s translation activity is his creativity. Together with the futuristic nature of the work of Jasieński himself, it contributes to the implementation of translations that preserve the mentioned features of authentic texts.
Synovial fluid fingerprinting in end-stage knee osteoarthritis
Authors: Jayadev Chethan , Hulley Philippa , Swales Catherine , Snelling Sarah , Collins Gary , Taylor Peter , Price Andrew 
Published: September 2020

Aims The lack of disease-modifying treatments for osteoarthritis (OA) is linked to a shortage of suitable biomarkers. This study combines multi-molecule synovial fluid analysis with machine learning to produce an accurate diagnostic biomarker model for end-stage knee OA (esOA). Methods Synovial fluid (SF) from patients with esOA, non-OA knee injury, and inflammatory knee arthritis were analyzed for 35 potential markers using immunoassays. Partial least square discriminant analysis (PLS-DA) was used to derive a biomarker model for cohort classification. The ability of the biomarker model to diagnose esOA was validated by identical wide-spectrum SF analysis of a test cohort of ten patients with esOA. Results PLS-DA produced a streamlined biomarker model with excellent sensitivity (95%), specificity (98.4%), and reliability (97.4%). The eight-biomarker model produced a fingerprint for esOA comprising type IIA procollagen N-terminal propeptide (PIIANP), tissue inhibitor of metalloproteinase (TIMP)-1, a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), monocyte chemoattractant protein (MCP)-1, interferon-γ-inducible protein-10 (IP-10), and transforming growth factor (TGF)-β3. Receiver operating characteristic (ROC) analysis demonstrated excellent discriminatory accuracy: area under the curve (AUC) being 0.970 for esOA, 0.957 for knee injury, and 1 for inflammatory arthritis. All ten validation test patients were classified correctly as esOA (accuracy 100%; reliability 100%) by the biomarker model. Conclusion SF analysis coupled with machine learning produced a partially validated biomarker model with cohort-specific fingerprints that accurately and reliably discriminated esOA from knee injury and inflammatory arthritis with almost 100% efficacy. The presented findings and approach represent a new biomarker concept and potential diagnostic tool to stage disease in therapy trials and monitor the efficacy of such interventions. Cite this article: Bone Joint Res 2020;9(9):623–632.
Barriers to clinical trial recruitment and recommendations for supporting breast surgeons in the workplace
Authors: O’Connell RL , Rattay T , Cutress RI , McIntosh SA , Potter S , Leff DR , Fairbrother P , Holcombe C 
Published: September 2020

To better understand how to support UK breast surgeons in clinical trial participation and recruitment, the Association of Breast Surgery (ABS) Academic and Research (A&R) Committee surveyed the ABS membership on the challenges and barriers surrounding the recruitment of patients to breast cancer clinical trials. Improving patient outcomes depends on better engagement with clinical research.
Virtual follow-up clinic for elective shoulder surgery: a safe and cost effective model
Authors: James M , Farooq D , Berntzen B , Mitra A , Tasker A , Woods D 
Published: September 2020

Virtual follow-up clinics are being increasingly used in orthopaedics, but their use in elective upper limb follow-up has not been extensively developed. This paper presents a successful model of virtual elective shoulder follow-up. One hundred and forty-two (70%) of the patients treated were discharged following the virtual clinic and only eight (4%) required consultant follow-up. Of those originally discharged, six (4%) needed further physiotherapy and one (0.7%) required consultant follow-up. Virtual follow-up clinics also made a profit of £6,700 for the hospital. Virtual elective shoulder follow-up is a safe and cost effective method of follow-up for shoulder manipulation under anaesthetic and subacromial decompression. With the optimisation of clinician time and financial benefits, is it time to update traditional pathways for postoperative clinics?
Effect of laser power on cleaning mechanism and surface properties
Authors: Wan Zhuang , Yang Xuefeng , Xia Guofeng , Li Dan , Liu Wenbo , Cheng Jian , Wang Shouren 
Published: September 2020

In this paper, the mechanism of laser dry cleaning was introduced, and the influence of different power on laser cleaning effect and surface performance after cleaning were investigated. The cleaning effect of 60–120 W cleaning power on the oxidized layer of a Q235 surface was analyzed by experiment and simulation. The results showed that the cleaning power of 70 W makes the surface performance after cleaning of the samples relatively optimized. The best cleaning power is 90 W. The sample surface of 100 W is the smoothest, but it causes slight damage to the matrix. The cleaning power of 120 W has the maximum friction coefficient, but it has the maximum damage to the matrix.
Patriotism and Islam on social media: How Pakistani publics revisit their allegiance to the state
Authors: Cheema Munira 
Published: September 2020

Abstract
This study focuses on a series of events related to the sudden disappearance of bloggers in Pakistan on 7 January 2017. Following the incident, the broadcast media reported that the bloggers were sharing blasphemous content and were involved in anti-state activities. This revelation triggered online conversations that questioned their sympathizers’ patriotism and loyalty to Islam. The study locates how this led to the emergence of several hashtag-led publics on Twitter. While focusing two hashtags that polarized the publics on the issue, the study utilizes discourse analysis to evaluate the discourses generated by the conservative and the liberal publics on patriotism and national identity. This study finds that while conflating national identity with Islam, the conservative discourse constitutes angry, threat-like closed statements that allowed no room for disagreement. Liberal publics, on the other hand, use strategic speaking to create anti-state discourse on patriotism. Despite the heated exchange between the two publics, I argue that on this occasion (event-led), Twitter offered the opportunity for initiating counter-narratives that refuse to translate patriotism in the idiom of religion. I see this as an occasional, episodic, yet unprecedented form of public sphering in Pakistani context that brings both liberals and conservatives in direct contact with each other.
The Impact of Fiscal Decentralization on Economic Growth in Central and Eastern Europe
Authors: Korotun Volodymyr , Kaneva Tetiana , Drepin Anton , Levaieva Liudmyla , Kucherenko Svitlana 
Published: September 2020

In this research, we evaluated the impact of fiscal decentralization on GDP per capita growth. Using the unbalanced panel data, the authors assessed the interconnections between fiscal decentralization – considering its expenditure and revenue aspects as well as tax autonomy – and economic growth for Central and Eastern European countries from 1995 to 2018. In the examined states, the expenditure decentralization exceeded the revenue one. We found out that revenue decentralization and tax autonomy adversely affected economic growth. But expenditure decentralization associated with a positive GDP growth rate. In this paper, we also explored the peculiarities of fiscal decentralization reform. Structural transformations radically reduced the size of the public sector in Central and Eastern Europe, which had a positive effect on the economy. The vital components of local budgets tax revenues are personal income tax and the property taxes. The most effective mechanism for the property tax base’s determination arises from the value of the real estate or land.
Keywords: fiscal policy, fiscal decentralization, tax autonomy, property taxes, economic growth
A Conceptual Framework Outlining Factors Affecting the Acceptance of Earth as a Sustainable Building Material in the United Kingdom
Authors: Zami Mohammad Sharif 
Published: September 2020

Despite the fact that contemporary earth construction may open up new avenues to cutting down CO2 emissions, a review of literature reveals that there is sparse research to date identifying reasons behind why there may be resistance to earth construction as a sustainable construction material in the United Kingdom. The aim of this paper is to formulate a conceptual framework that facilitates a clearer understanding of factors affecting the acceptance of earth as a sustainable material in the UK. To achieve this aim, this study adopted a research methodological framework comprising of an extensive review of literature, the Delphi technique, and in-depth interviews. The conceptual framework provides insight into factors related to the UK context specifically including a lack of technological innovation, resources, well-established supply chain networks, training facilities in universities and building codes. These issues may be addressed through the promotion of earthen architecture as a method of cutting CO2 emissions and introducing earth construction modules in relevant degree programs.
Keywords: conceptual framework, factors, building material, earth, environmental sustainability
Commercial and Legal Regulation of Advisory Services in the Ukrainian Agrarian Business Prospect Reform
Authors: Kovalchuk Inna , Melnyk Olesia , Pakhomova Anna 
Published: September 2020

The article is devoted to theoretical and practical aspects of reforming the commercial and legal regulation of advisory services in the agrarian business of Ukraine. The characteristic of agricultural advisory activity model structure in Ukraine is given, which currently consists of several levels of subjects of such activity: the first level - national, nationwide; second level - regional; third level - local; fourth level - personal. Particular attention is given to the legal analysis of the essence of "advisory services in the agricultural business" as a type of commercial activity, and taking into account the provisions of the current legislation, it is proved that in its essence and legal nature - agribusiness advisory is an institution of commercial law. The article examines and characterizes a typical business agreement for the provision of advisory services in the agricultural sector of the Ukrainian economy, the essential conditions for this type of contracts are given, and their characteristics are defined. The advisory activity is seen as an effective instrument of state agrarian policy.
Keywords: commercial and legal regulation, advisory service, advisory activity, agrarian business, advisor, expert consulting services, consulting
Sustainable Digitalization in Public Institutions: Challenges for Human Rights
Authors: Pūraitė Aurelija , Adamonienė Rūta , Žemeckė Audronė 
Published: September 2020

The modern world is bound not only by global flows of information, capital, services, and movement of goods and people but also by the wide range of opportunities to exert both positive and negative effects on these flows. Already, most of the aforementioned global flows, stationary and variable objects are protected (organized, coordinated, controlled) by digital technology and in the foreseeable future digitization will encompass the most diverse aspects and processes of existence. Access to the development, deployment, management and use of relevant digital technologies has expanded to such an extent that it has become virtually difficult and even impossible to provide timely protection against a wide range of actors, ranging from unauthorized specialized gathering to varying degrees of security. The development of information technology, which increasingly embraces various aspects of the existence of different security entities, calls for a new rethink of the philosophical - ideological, political, economic, social and cultural foundations of public security. In recent decades human rights have dominated in the discourse of legal and political systems. Now the balance between protection of human rights and public safety in the context of digitalization imposes necessity to reflect the concept of fundamental rights once again. Keywords: Sustainable digitalization, public and private security, human rights
Evaluation of the Barrier-Free Tourism and Sustainability of the Barrier-Free Society in Cyprus
Authors: Altinay Fahriye , Altinay Zehra , Altinay Mehmet , Dagli Gökmen 
Published: September 2020

The main aim of the current study is to evaluate the opinions of the students at the departments of tourism and special education towards to the concept of sustainability of barrier-free tourism and society therefore with the light of this aim, and current study attempted to address how disabled individuals could have an access to the tourism and life opportunities as well as the challenges that they are experiencing while having an access to these opportunities, probable solutions which might be employed to cope with these challenges, universal rights of the disabled individuals about having an access and transportation in contexts barrier-free tourism practices in TRNCThe current study employed a semi-structured interview as a data collection tool. The study group of the current research consisted of 80 participants who are the students at the tourism and specialized education teaching departments at Near East University and the University of Kyrenia. Data were collected with 20 minutes face to face interviews. While performing data analysis, responses of the participants were categorized and placed to the tables and then the researcher(s) re-examined the classified data set and formed underlying themes and categories. With the light of the findings, it can be stated that education at universities, secondary and primary schools should be intensified to inject necessary information to the students regarding barrier free tourism and provision of health care services for disabled people. At the reffered point. joint commitment should be carried among ministry of education, tourism, heallth and municipalities to raise public awareness regarding barrier free tourism. Additionally media and press should design more programs regarding barrier free tourism at their broadcasting stream to raise public awareness, and in-service trainings for disabled people should be provided to employees in hotels.
Keywords: Barrier- Free Tourism, Sustainable Society, Education, Accessibility, Awareness
Oil and Fat Business of Ukraine: Marketing Orientation for Achieving Competitive Advantages
Authors: Gonchar Olga , Zamkova Nataliia , Polishchuk Iryna , Dovhan Yuriy , Sokolovska Valentyna 
Published: September 2020

The article examines theoretical approaches to achieving the competitive advantages of Ukrainian oil and fat enterprises in modern market conditions. Special attention is paid to the peculiarities of the use in business management of marketing concepts of business organization, which are oriented at the market, needs of consumers, society and other stakeholders. The most effective results for the enterprises are provided by the implementation of marketing management concepts that are oriented at identifying and meeting consumer demand as well as consideration of the interests of all other stakeholders in the supply chain of oil and fat products, the individual, community and society, i.e. concepts of marketing interaction and holistic marketing.
The supply chain of oil and fat products includes the economic interests of business entities that develop varieties of oil and fat seeds, machinery and technology, supply of resources, production of raw materials, processing, storage and transportation, etc. A key position in the supply chain is occupied by the consumer. The success of the marketing strategy of the enterprise depends on the degree of consideration of the interests of the individual, communities, society and the state.
It is concluded that oil and fat companies in the food industry can gain sustainable competitive advantages due to integration efforts aimed to form agricultural and food clusters in local geographical areas from all stakeholders and relationships in the supply chain of oil and fat products including suppliers, manufacturers, intermediaries, consumers, government and other organizations, etc.
Keywords: oil and fat business, marketing orientation, competitive advantages, supply chain, stakeholders, interests, oil and fat cluster.