bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19
Authors: Hou H , Zhang B , Huang H , Luo Y , Wu S , Tang G , Liu W , Mao L , Mao L , Wang F , Sun Z 
Published: May 2020

SummaryEffective laboratory markers for the estimation of disease severity and predicting the clinical progression of coronavirus disease-2019 (COVID-19) is urgently needed. Laboratory tests, including blood routine, cytokine profiles and infection markers, were collected from 389 confirmed COVID-19 patients. The included patients were classified into mild (n = 168), severe (n = 169) and critical groups (n = 52). The leukocytes, neutrophils, infection biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) and ferritin] and the concentrations of cytokines [interleukin (IL)-2R, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α] were significantly increased, while lymphocytes were significantly decreased with increased severity of illness. The amount of IL-2R was positively correlated with the other cytokines and negatively correlated with lymphocyte number. The ratio of IL-2R to lymphocytes was found to be remarkably increased in severe and critical patients. IL-2R/lymphocytes were superior compared with other markers for the identification of COVID-19 with critical illness, not only from mild but also from severe illness. Moreover, the cytokine profiles and IL-2R/lymphocytes were significantly decreased in recovered patients, but further increased in disease-deteriorated patients, which might be correlated with the outcome of COVID-19. Lymphopenia and increased levels of cytokines were closely associated with disease severity. The IL-2R/lymphocyte was a prominent biomarker for early identification of severe COVID-19 and predicting the clinical progression of the disease.
Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study
Authors: Janović Nataša , Ćoćić Aleksandar , Stamenić Mirjana , Janović Aleksa , Djurić Marija 
Published: May 2020

AbstractObjectivesThe objective of this study was to investigate the relationship between side asymmetry in nasal resistance (NR) and severity of the nasal airway obstruction (NAO) in patients with different types of nasal septal deformity (NSD).DesignComputational fluid dynamics (CFD) study.SettingThe study was conducted in a tertiary medical centre.ParticipantsThe study included 232 patients, who were referred to the CT examination of the paranasal sinuses. Exclusion criteria were sinonasal and respiratory diseases that may interfere with the nasal obstruction. The presence and the type of NSD were recorded according to the Mladina's classification.Main outcome measuresThe presence and severity of NAO in each patient were assessed by NOSE questionnaire. Eight computational models of the nasal cavity were created from CT scans. Models represented seven Mladina's NSD types and a straight septum of a symptomless patient. CFD calculated airflow partitioning and NR for each nasal passage. Side differences in NR were calculated by the equation ∆NR = NRleft − NRright. The relationship between NOSE scores, airflow partitioning and side differences in NR was explored using Spearman's correlation analysis.ResultsMladina's types of NSD showed differences in airflow partitioning and the degree of side asymmetry in NR. A significant positive correlation was detected between side differences in NR and NOSE scores (R = .762, P = .028). A significant negative correlation was found between the per cent of unilateral airflow and NR (R = −.524, P = .037).ConclusionsOur results demonstrated that side asymmetry in NR could explain differences in NAO severity related to the NSD type.
Association of low skeletal muscle mass with the presence of advanced colorectal neoplasm: integrative analysis using three skeletal muscle mass indices
Authors: Lee H. J. , Lee J. Y. , Lee M. J. , Kim H.‐K. , Kim N. , Kim G.‐U. , Lee J.‐S. , Park H. W. , Chang H.‐S. , Yang D.‐H. , Choe J. , Byeon J.‐S. 
Published: May 2020

AbstractAimThis study aimed to evaluate an association between colorectal neoplasm (CRN) and skeletal muscle mass using three widely accepted skeletal muscle mass indices (SMIs) in a large population at average risk.MethodWe performed a cross‐sectional study using a screening colonoscopy database of 33 958 asymptomatic subjects aged 40–75 years. Appendicular skeletal muscle mass (ASM) was measured using a bioelectrical impedance analyser. ASM adjusted for height squared (ASM/ht2), weight (ASM/wt) and body mass index (ASM/BMI) were used as indices for muscle mass. Logistic regression models were used to evaluate the association between SMIs and CRN.ResultsIn a multivariable‐adjusted model, the risk of an advanced CRN increased linearly with decreasing quartiles for all three SMIs. The adjusted odds ratios (ORs) for advanced CRN in quartiles 1, 2 and 3 of ASM/wt compared with that in quartile 4 were 1.279, 1.196 and 1.179, respectively (Ptrend = 0.017); for ASM/BMI, ORs were 1.307, 1.144 and 1.091, respectively (Ptrend = 0.002); and for ASM/ht2, ORs were 1.342, 1.169 and 1.062, respectively (Ptrend = 0.002). The risk of distally located advanced CRN was higher in quartile 1 than in quartile 4 for all three SMIs (ASM/wt, OR = 1.356; ASM/BMI, OR = 1.383; ASM/ht2, OR = 1.430).ConclusionOur study demonstrated that low skeletal muscle mass was consistently associated with the presence of advanced CRN in a population at average risk regardless of the operational definition of the SMI, and it was particularly associated with distal advanced CRN.
The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma
Authors: Lu Yu , Wu Min , Fu Jie , Sun Yichen , Furukawa Kenei , Ling Jianhua , Qin Xue , Chiao Paul J. 
Published: May 2020

AbstractObjectivesRecent observations have emphasized the role of long non‐coding RNA (lncRNA) in cancer progression; however, a genetic profile of lncRNAs in pancreatic ductal adenocarcinoma (PDAC) remains an ongoing study.Materials and MethodsIn this research, RNA sequencing showed that LINC00162 is dramatically increased in patient‐derived tumour cell lines (PATC) compared with the human pancreatic nestin‐positive epithelial (HPNE) cells.ResultsThese data were validated in several PDAC cell lines, and significant upregulation of LINC00162 was found in all of them. Knock‐down of LINC00162 significantly inhibited the proliferation, colony formation and migration of PATC cells in vitro and suppressed the growth of PATC xenografts in vivo. Overexpression of LINC00162 in PDAC cell lines (AsPc‐1) showed consistent results, with significantly increased proliferation, colony formation and migration of AsPc‐1 cells, as well as enhanced tumour growth of the AsPc‐1 xenografts in vivo. Furthermore, the result of Chromatin immunoprecipitation assay revealed that RelA/p65 directly bound to LINC00162, and the expression of LINC00162 in PDAC decreased after RelA/p65 knock‐down, the proliferation ability of AsPc‐1 also significantly inhibited after knocking down LINC00162 and RelA/p65 simultaneously, indicating that RelA/p65 directly involve in the transcriptional regulation of LINC00162.ConclusionsIn sum, our results provide first evidence for the role of LINC00162 in promoting PDAC progression and the potential underlying mechanism of LINC00162 overexpression.
A new model to determine Optimal Exposure to Tacrolimus and Mycophenolate Mofetil after renal transplantation
Authors: Pankewycz Oleh , Onan Engin , Rucker Dane , Wang Dongliang , Gruessner Angelika , Gruessner Rainer , Laftavi Mark R. 
Published: May 2020

AbstractBackgroundDrug dosing for Tacrolimus (TAC) and Mycophenolate Mofetil (MMF) after kidney transplantation remains challenging. Therapeutic drug monitoring (TDM) offers a means to individualize drug dosing and improve outcomes.MethodsIn this observational study, patients having mycophenolic acid (MPA) exposure assessed by limited sampling strategy (LSS) within the first 6 months were included and followed for 1 year.ResultsA total of 113 clinical events occurring in 110 patients were classified into 3 groups: Group 1 Stable (n = 34), Group 2 Over drug exposed (n = 64) having infections or drug toxicity and Group 3 Under drug exposed (n = 15) developing rejection or de novo donor‐specific alloantibodies. Although TAC levels, MMF dose, MPA, and MPA Glucuronide (MPAG) exposure, expressed as area under curve (AUC), individually failed to predict outcomes, a scoring model incorporating all 3 drug levels TAC TDM × (MPA AUC + MPAG/10 AUC) correctly classified outcomes. A score over 1071 had a sensitivity and specificity of 0.94 (95% CI 0.56‐0.83) and 0.84 (95% CI 0.69‐0.89) for over exposure. A score below 625 had a sensitivity and specificity of 0.76 (95% CI 0.53‐0.93) and 0.80 (95% CI 0.41‐0.70) for under exposure.ConclusionsThis integrated model of assessing TAC and MMF exposure may facilitate individualized therapy.
Digital Literacy and Liberative Community Engagement
Authors: Chow‐Thomas Ann 
Published: May 2020

AbstractHow can institutions really open up and promote their archival collections through creative interventions? This question was posed when devising the In Our Minds project, a collaborative project between The National Archives U.K. and University for the Creative Arts (UCA) Archive, U.K. This article reflects on digital literacy as a means to create content and use digital platforms to engage, promote and disseminate information as part of the project's aims and outcomes. It also assesses how creative interventions can open up and increase awareness to certain collections through the defined theme of mental health, by individual creative practitioners, and developing exhibition strategies for a touring exhibition with physical and digital artworks.
The Partnership Quilt: An Interactive Living Archive of Sex Worker Voices
Authors: Strohmayer Angelika , Meissner Janis 
Published: May 2020

AbstractWorking alongside people who use and manage a local charity and professional quilters, we sewed a quilted blanket which we augmented with capacitive touch sensors to turn the craft Piece into an interactive archiver. In this way, the quilt tells the story of the women who were involved in making it not only through the seams, but also with our embedded voices. We describe the process of quilting a digitally augmented social fabric and the ways in which the sewing allowed us to learn through the seams, we present a project that brings together aspects of human connection, crafted learning, and living archival practice.
iGlarLixi effectively reduces residual hyperglycaemia in patients with type 2 diabetes on basal insulin: A post hoc analysis from the LixiLan‐L study
Authors: Morea Nicola , Retnakaran Ravi , Vidal Josep , Aroda Vanita R. , Liu Minzhi , Saremi Aramesh , Giorgino Francesco 
Published: May 2020

AbstractGlobally, nearly half of patients with type 2 diabetes (T2D) do not successfully achieve target HbA1c with basal insulin, despite meeting fasting plasma glucose (FPG) targets. In this post hoc analysis of the LixiLan‐L study, we determined whether iGlarLixi, a fixed‐ratio combination of insulin glargine Gla‐100 (iGlar) and the glucagon‐like peptide‐1 receptor agonist lixisenatide (Lixi), addresses the challenge of reducing residual hyperglycaemia in patients with T2D. In LixiLan‐L, a randomized, open‐label study, 1018 patients with T2D on basal insulin for ≥6 months ± oral antidiabetes drugs entered a 6‐week run‐in period, during which they were switched to and/or optimized for a daily dose of iGlar while continuing only metformin. Following the run‐in period, 736 patients were then randomized to receive iGlarLixi or were continued on iGlar for 30 weeks ± metformin. Residual hyperglycaemia was defined as HbA1c ≥ 7.0% despite FPG of <140 mg/dL. The proportion of patients with residual hyperglycaemia was similar in both treatment arms at screening (~~42%), and increased after the run‐in period (~~62%). After 30 weeks, the proportion of patients with residual hyperglycaemia declined to 23.8% in the iGlarLixi versus 47.1% in the iGlar arm (P < .0001). The proportion of patients achieving both HbA1c (<7.0%) and FPG (<140 mg/dL) targets was higher in the iGlarLixi compared with the iGlar arm (50.3% vs. 27.4%, respectively; P < .0001). iGlarLixi effectively reduces residual hyperglycaemia in patients with T2D on basal insulin therapy.
Exploration of constructive feedback practices in dental education chairside teaching: A case study
Authors: Prastiyani Nur H. N. , Felaza Estivana , Findyartini Ardi 
Published: May 2020

AbstractBackgroundChairside teaching is one of the teaching–learning methods in clinical dental education in which direct care is provided to patients. When students have been deemed competent in carrying out procedures on a dental phantom, they need clinical experience on patients, with guidance and constructive feedback from clinical teachers. Constructive feedback is an important learning platform in helping students analyse the strong and the weak aspects of their performance in order to identify required improvements. This study aimed to explore the practice of giving constructive feedback in chairside teaching.MethodA qualitative method with a case study design. Data were collected through in‐depth interviews and focus group discussions (FGDs) with clinical teachers and students in clinical rotation. Data triangulation was carried out by observing the practice of giving constructive feedback in chairside teaching and document analysis from January to April 2019. Results of the in‐depth interviews and FGDs were transcribed verbatim and analysed using a thematic analysis approach.ResultIn‐depth interviews with five programme coordinators and FGDs with two groups of clinical teachers (N = 8 and N = 6) and two clinical student groups (N = 8 each). Three main themes emerged in this study: ways to provide feedback, challenges on feedback provision and challenges on feedback follow‐up.ConclusionDifferences in perception between clinical teachers and students were identified, influenced by students' interactions with the learning environment. Interventions are to be encouraged that involve teachers, students and institutions, and the interactions amongst the three.
Significance of CD10 protein expression in the diagnostics of follicular lymphoma: A comparison of conventional immunohistochemistry with flow cytometry supported by the establishment of BCL2 and BCL6 rearrangements
Authors: Szumera‐Ciećkiewicz Anna , Rymkiewicz Grzegorz , Sokół Kamil , Paszkiewicz‐Kozik Ewa , Borysiuk Anita , Poleszczuk Jan , Bachnio Katarzyna , Bystydzienski Zbigniew , Woroniecka Renata , Grygalewicz Beata , Kotarska Martyna , Stańczak Monika , Owczarek Daria , Pytlak Beata , Prochorec‐Sobieszek Monika , Walewski Jan 
Published: May 2020

AbstractIntroductionHistopathological examination and immunohistochemistry (IHC) with a crucial role of CD10 expression remain a standard diagnostic tool in follicular lymphoma (FL). The results of IHC CD10 detection with different primary antibodies are not fully reproducible, but some reports show that flow cytometry (FCM) can be a reliable method of CD10 identification.MethodsThe aim of the study was to compare results of CD10 expression in FL by IHC and FCM including immunophenotypic features in the context of the BCL2 and BCL6 alterations.ResultsOut of 76 histopathologically diagnosed FL, a group of 25 cases had simultaneously FCM. Immunohistochemically 77.6% of cases were CD10‐positive with comparable and reproducible results to FCM. Differences between the FCM expression of CD5/CD10/CD11c/CD25/CD43 and BCL2 overexpression (BCL2(+)higher) correlated with the BCL2 and BCL6 rearrangements (R) status. Lack of CD10 expression corresponded with the absence of BCL2R and higher MUM1 expression by IHC results but had no clinical impact on the long‐time outcomes.ConclusionsImmunohistochemistry staining is a comparable method to FCM assessment in the evaluation of CD10 expression and diagnosis of FL. Fine‐needle aspiration biopsy/FCM (FNAB/FCM) could be a useful tool for verifying FL diagnosis and CD10 detection. Despite its heterogeneity, FL has a characteristic immunophenotype. BCL2R and BCL6R FL cases differ mainly in levels of BCL2 and CD10 with CD43 co‐expression; BCL2(+)higher by FCM correlates with BCL2R. Moreover, FNAB plays an important role in material provision for supportive karyotyping and BCL2R, BCL6R assessed by FISH.
High‐pressure behavior and phase stability of Na2B4O6(OH)2·3H2O (kernite)
Authors: Comboni Davide , Pagliaro Francesco , Gatta G. Diego , Lotti Paolo , Milani Sula , Merlini Marco , Battiston Tommaso , Glazyrin Konstantin , Liermann Hanns‐Peter 
Published: May 2020

AbstractThe high‐pressure behavior of kernite [ideally Na2B4O6(OH)2·3H2O, a ~ 7.02 Å, b ~ 9.16 Å, c ~ 15.68 Å, β = 108.9°, Sp Gr P21/c, at ambient conditions], an important B‐bearing raw material (with B2O3 ≈ 51 wt%) and a potential B‐rich aggregate in radiation shielding materials, has been studied by single‐crystal synchrotron X‐ray diffraction up to 14.6 GPa. Kernite undergoes an iso‐symmetric phase transition at 1.6‐2.0 GPa (to kernite‐II). Between 6.6‐7.5 GPa, kernite undergoes a second phase transition, possibly iso‐symmetric in character (to kernite‐III). The crystal structure of kernite‐II was solved and refined. The isothermal bulk modulus (KV0 = β‐1P0,T0, where βP0,T0 is the volume compressibility coefficient) of the ambient‐pressure polymorph of kernite was found to be KV0 = 29(1) GPa and a marked anisotropic compressional pattern, with K(a)0: K(b)0: K(c)0~1:3:1.5., was observed. In kernite‐II, the KV0 increases to 43.3(9) GPa and the anisotropic compressional pattern increases pronouncedly. The mechanisms, at the atomic scale, which govern the structure deformation, have been described.
A computational modeling framework for reaction and failure of environmental barrier coatings under silicate deposits
Authors: Summers William D. , Poerschke David L. , Begley Matthew R. , Levi Carlos G. , Zok Frank W. 
Published: May 2020

AbstractEnvironmental barrier coatings (EBCs) for use with SiC‐based composites in gas turbine engines may fail following reaction with molten silicate deposits. The processes involved may include dissolution of the EBC material into the deposit, reactions that produce new phases, and cracking or spallation upon cooling, the latter driven by thermal expansion mismatch between the reaction products and the underlying EBC and substrate. Here, we describe an integrated computational framework to simulate the processes and to predict the conditions leading to coating loss through reactive consumption and/or spallation. The framework integrates distinct models to determine: (a) the nature and quantity of phases resulting from dissolution and chemical reactions; (b) thermo‐physical properties of those phases; and (c) energy release rates for penetration cracking and spallation upon cooling. We demonstrate the use of the framework by computing critical deposit thicknesses for one specific EBC material (Y2Si2O7) as a function of deposit composition. In this system, the critical deposit thickness for typical coating thicknesses is dictated mainly by spallation, not by consumption, and may vary by orders of magnitude, depending on deposit composition and coating thickness and toughness. With respect to deposit composition, the key parameter governing coating failure is the Ca:Si ratio.
How pathogens affect the marine habitat use and migration of sea trout (Salmo trutta) in two Norwegian fjord systems
Authors: Lennox Robert J. , Eldøy Sindre H. , Vollset Knut W. , Miller Kristi M. , Li Shaorong , Kaukinen Karia H. , Isaksen Trond E. , Davidsen Jan G. 
Published: May 2020

AbstractWild fish are confronting changing pathogen dynamics arising from anthropogenic disturbance and climate change. Pathogens can influence animal behaviour and life histories, yet there are little such data from fish in the high north where pathogen dynamics may differ from comparatively southern regions. We aimed to compare the pathogen communities of 160 wild anadromous brown trout in two fjords in northern Norway and to determine whether pathogens influenced area use or return to spawn. Application of high‐throughput qPCR detected 11 of the 46 pathogens screened for; most frequently encountered were Ichthyobodo spp., Flavobacterium psychrophilum and Candidatus Branchiomonas cysticola. The rate of returning to freshwater during the spawning season was significantly lower for the Skjerstadfjord fish. Piscichlamydia salmonis and F. psychrophilum were indicator species for the Skjerstadfjord and pathogen communities in the two fjords differed according to perMANOVA. Individual length, Fulton's condition factor and the time between first and last detection of the fish were not related to the presence of pathogens ordinated using non‐metric multidimensional scaling (NMDS). However, there was evidence that pathogen load was correlated with the expression of smoltification genes, which are upregulated by salmonids in freshwater. Correspondingly, percentage of time in freshwater after release was longer for fish with greater pathogen burdens.
The effect of a comprehensive mobile application program (CMAP) for family caregivers of home‐dwelling patients with dementia: A preliminary research
Authors: Park Eunsil , Park Heeok , Kim Eun Kyung 
Published: May 2020

AbstractAimThe purpose of this study was to evaluate the effect of a comprehensive mobile application program in managing behavior and psychological symptoms of home‐dwelling patients with dementia in South Korea.MethodsA nonequivalent control group pretest‐posttest design was conducted. A total of 26 family caregivers participated in this study. The application program consists of understanding of dementia, interventions, communication skills, coping methods, and bulletin boards. Data collection was performed from July 9, 2018, to October 4, 2018. Family caregivers' fatigue, sleep, and burden and patients with behavioral and psychological symptoms of dementia were measured. For data analysis, descriptive statistics, independent t tests, Mann–Whitney U test, repeated measures analysis of variance, and Friedman test were used.ResultsThe application program offered environmental management in an intervention using communication skills and coping methods, depending on the behavioral and psychological symptom type. The results showed significant differences between the two groups in family caregivers' fatigue (F = 11.24, p = .003) and burden (χ2 = 10.55, p = .005).ConclusionThe findings showed the application program improved family caregivers' fatigue and burden. It also suggested there is a need to develop a wandering persons location program to improve family caregivers' stress and patients' behavioral problems in future studies.