bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the concordance in HPV type between self- and physician-collected samples using a brush-based device and a PCR-based HPV DNA test in Japanese referred patients with abnormal cytology or HPV infection
Authors: Onuma Toshimichi , Kurokawa Tetsuji , Shinagawa Akiko , Chino Yoko , Yoshida Yoshio 
Published: July 2020

Abstract
Background
To adopt HPV self-sampling in Japan, we assessed the concordance between self- and physician-collected human papillomavirus (HPV) samples from Japanese patients and examined the performance of HPV self-sampling for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).

Methods
Patients who had previously tested negative for intraepithelial lesions or malignancy/HPV-positive, and patients with atypical squamous cells of undetermined significance or worse (ASCUS+) cytology were eligible for this cross-sectional study. Participants performed HPV self-sampling using an Evalyn brush, which was submitted at the Fukui Prefectural Health Care Association. The Evalyn brush heads were stored in ThinPrep vials. The physician, however, performed HPV and cell sampling using an endocervical brush and immediately stored the brush heads in ThinPrep vials. All participants underwent colposcopy and biopsy. Histopathological diagnoses were made by pathologists at Fukui University Hospital. HPV infection was confirmed using a PCR-based Cobas 4800 HPV DNA test. Cytological analysis was performed at Fukui Prefectural Health Care Association.

Results
HPV-positive rates for physician-collected samples and self-collected samples were 51 and 50%, respectively. The perfect match rate of HPV type between the groups was 88% (κ = 0.76). HPV16/18 showed higher agreement rates than other HPVs (99%, kappa 0.96 and 89% kappa 0.77, respectively). Both groups showed 100% sensitivity to CIN2+, but specificity was 57.0 and 58.1%, respectively.

Conclusion
For HPV typing, a good concordance rate was seen between self- and physician-collected samples. Self-sampling showed high sensitivity for CIN2+. Self-sampling using the Evalyn brush and Cobas 4800 may be feasible for screening Japanese individuals.
The Emergence of Autism Symptoms Prior to 18 Months of Age: A Systematic Literature Review
Authors: Tanner Amy , Dounavi Katerina 
Published: July 2020

AbstractPre-diagnostic intervention for autism spectrum disorder (ASD) allows symptoms to be addressed as they emerge, often between six to 18 months, rather than after the full onset of the disorder. A systematic literature review, spanning the previous six years was conducted in order to provide an updated review looking at the earliest behavior symptoms of ASD. All included studies used a prospective experimental design, reported on symptoms that emerged before 18-months of age, exclusively in children who would later receive a diagnosis, and were assessed for quality. This review is the first to address this research question through the use of a systematic research design and extends the literature by following up on recommendations for future research from previous findings.
Emergence of Haldane Pseudo-Potentials in Systems with Short-Range Interactions
Authors: Seiringer Robert , Yngvason Jakob 
Published: July 2020

AbstractIn the setting of the fractional quantum Hall effect we study the effects of strong, repulsive two-body interaction potentials of short range. We prove that Haldane’s pseudo-potential operators, including their pre-factors, emerge as mathematically rigorous limits of such interactions when the range of the potential tends to zero while its strength tends to infinity. In a common approach the interaction potential is expanded in angular momentum eigenstates in the lowest Landau level, which amounts to taking the pre-factors to be the moments of the potential. Such a procedure is not appropriate for very strong interactions, however, in particular not in the case of hard spheres. We derive the formulas valid in the short-range case, which involve the scattering lengths of the interaction potential in different angular momentum channels rather than its moments. Our results hold for bosons and fermions alike and generalize previous results in [6], which apply to bosons in the lowest angular momentum channel. Our main theorem asserts the convergence in a norm-resolvent sense of the Hamiltonian on the whole Hilbert space, after appropriate energy scalings, to Hamiltonians with contact interactions in the lowest Landau level.
Nickel-Catalysed Vapour-Phase Hydrogenation of Furfural, Insights into Reactivity and Deactivation
Authors: MacIntosh Kathryn L. , Beaumont Simon K. 
Published: July 2020

AbstractFurfural is a key bioderived platform molecule, and its hydrogenation affords access to a number of important chemical intermediates that can act as “drop-in” replacements to those derived from crude oil or novel alternatives with desirable properties. Here, the vapour phase hydrogenation of furfural to furfuryl alcohol at 180 °C over standard impregnated nickel catalysts is reported and contrasted with the same reaction over copper chromite. Whilst the selectivity to furfuryl alcohol of the unmodified nickel catalysts is much lower than for copper chromite as expected, the activity of the nickel catalysts in the vapour phase is significantly higher, and the deactivation profile remarkably similar. In the case of the supported nickel catalysts, possible contribution to the deactivation by acidic sites on the catalyst support is discounted based on the similarity of deactivation kinetics on Ni/SiO2with those seen for less acidic Ni/TiO2and Ni/CeO2. Powder X-ray diffraction is used to exclude sintering as a primary deactivation pathway. Significant coking of the catalyst (~ 30 wt% over 16 h) is observed using temperature programmed oxidation. This, in combination with the solvent extraction analysis and infrared spectroscopy of the coked catalysts points to deactivation by polymeric condensation products of (reactant or) products and hydrocarbon like coke. These findings pave the way for targeted modification of nickel catalysts to use for this important biofeedstock-to-chemicals transformation.
The Yuktidīpikā on the Origin of the Vedas
Authors: Łucyszyna Ołena 
Published: July 2020

AbstractIn this article, I reconstruct the view of the Yuktidīpikā, the most detailed and profound commentary of classical Sāṃkhya, on the origin of the Vedas. A close reading of the text reveals that its unknown author wavered between at least two different views on this issue. The first view is that the authorless but noneternal Vedas evolve from prakṛti (primordial matter) at the beginning of a new cycle of existence of the world (kalpa) and merge into prakṛti during a cosmic dissolution (pralaya). The Yuktidīpikā is the first text in classical Sāṃkhya to state directly that the Vedas have no author. The second and opposite view is that Kapila is the author of the highest teaching of the Vedas. This view is expressed only indirectly. Besides reconstructing the above-mentioned views, I attempt to answer the question of whether by quoting Nirukta 1.20 the Yuktidīpikā communicates something about the origin of the Vedas. Illustrating Sāṃkhya thought by quoting this passage of the Nirukta, as well as proclaiming the idea that the Vedas are authorless, which became the “official” standpoint of the Sāṃkhya darśana, can be interpreted as elements of the Yuktidīpikā’s pioneering project to show that Sāṃkhya is not in conflict with the Vedas.
The Vicissitudes of Representation
Authors: Mandarini Matteo 
Published: July 2020

AbstractThis article turns to the issue of political representation that I argue is central to all forms of political thought and practice of the modern period. Taking political representation as its object, I argue that its crisis—that comes to a head in the travails of the Weimar Republic—provided the opportunity for forms of neoliberal representation to displace political representation with purportedly “neutral”, non-partisan and thus “fair” representational tools. In contrast, I seek to develop the idea of “self-representation” with a discussion of paths not chosen at Weimar and via Italianoperaismo’s reflections on “class composition”, which combines collective self-representation with political organization. Representing each member of a collective to another as it develops epistemic and cartographic tools, it constructs group solidarity, organization and the capacity to act as it reclaims the collectivity alienated in modern political forms of representation and excluded from neoliberal ones.
Regression Estimator for the Tail Index
Authors: Németh László , Zempléni András 
Published: July 2020

AbstractEstimating the tail index parameter is one of the primal objectives in extreme value theory. For heavy-tailed distributions the Hill estimator is the most popular way to estimate this parameter. Several recent publications’ aim was to improve the Hill estimator, using different methods, for example the bootstrap, or the Kolmogorov–Smirnov metric. These methods are asymptotically consistent, but for tail index$$\xi >0.5$$ξ>0.5the estimations fail to approach the theoretical value for realistic sample sizes. In this paper, we introduce new empirical methods, which combine the advantages of the Kolmogorov–Smirnov approach and the bootstrap. We demonstrate that our estimators are able to estimate large tail index parameters well and might also be useful for relatively small sample sizes. As an application, we consider the classic Danish fire data set and the most destructive natural disasters in Europe.
The use of noncash payment methods for regular payments and the household demand for cash: evidence from Japan
Authors: Fujiki Hiroshi 
Published: July 2020

AbstractUnderstanding the demand for cash and noncash payment methods is an important policy concern in Japan, as the Japanese government aims at a cashless economy. Previous studies show that the demand for specific payment methods depends not only on the motivations of the kind of transactions, such as day-to-day transactions or hoarding, but also on payment contexts, such as bill payments or online payments. However, a few studies have investigated the demand for payment methods by payment context in Japan. We fill this gap by examining Japanese family and single-person household data on the choice of cash and noncash payment methods for regular payments, including bill payments. We found a decreasing popularity of choices involving automatic withdrawals and an increasing popularity of choices involving credit cards in both data sets and that of choosing exclusively cash in the single-person households’ data. We also found that these changes are associated with a decreasing demand for cash in family households and, conversely, an increasing demand in single-person households, assuming that the current pace of gradual adoption of noncash payment methods continues. In promoting a cashless society, the Japanese government should pay attention to the finding that a more frequent use of credit cards for regular payments is not always associated with a decrease in the demand for cash.
Evaluation of Eltrombopag in Thrombocytopenia Post Hematopoietic Cell Transplantation
Authors: Samarkandi H. , Al Nahedh M. , Alfattani A. , Alsharif F. , Bakshi N. , Rasheed W. , Alfraih F. , Alhumaid M. , Alkhudair Nora , Alhayli S. , Alsaedi H. , Shaheen M. , Hanbali A. , Hashmi S.K. , Devol E. , Alseraihy A. , Alzahrani H. , Aljurf M. 
Published: July 2020

Background:
Thrombocytopenia remains a life-threatening late complication of HCT with an incidence of 5–20%. Currently, there is no approved drug for the treatment of persistent thrombocytopenia post HCT and platelet transfusion is the maintain stay of treatment. Eltrombopag is approved for the treatment of thrombocytopenia associated with different diseases, however; data on eltrombopag treatment post HCT are limited.

Methods:
This is a retrospective cohort study evaluating the effect of eltrombopag on platelet recovery in patients with persistent thrombocytopenia post HCT. The primary endpoint was platelet recovery to ≥ 20,000/μL for 7 consecutive days without transfusion support after starting eltrombopag. Secondary endpoint was platelet recovery to ≥ 50,000/μL for 7 consecutive days.

Results:
Twenty-one patients were included. Twelve (75%) of 16 patients became independent from platelet transfusions. Median time from starting eltrombopag to last transfusion was 60 days (range, 9–226 days). Ten (63%) of 16 transfusion dependent patients with platelet count < 20,000/μL achieved the primary endpoint. Seven (33%) patients of 21 included had successful platelet recovery (ie, ≥50,000/μL without transfusion support) and the median time to platelet recovery in patients who achieved it was 32 days (range, 13–265 days). Ten patients (48%) were able to successfully discontinue eltrombopag without recurrence of thrombocytopenia.

Conclusion:
Our findings demonstrated that eltrombopag appears to have a clinically significant impact on platelet recovery in persistent thrombocytopenic patients post HCT.
Decontamination and reuse of surgical masks and N95 filtering facepiece respirators during the COVID-19 pandemic: A systematic review
Authors: Seresirikachorn Kachorn , Phoophiboon Vorakamol , Chobarporn Thitiporn , Tiankanon Kasenee , Aeumjaturapat Songklot , Chusakul Supinda , Snidvongs Kornkiat 
Published: July 2020

AbstractObjectives:Surgical masks and N95 filtering facepiece respirators (FFRs) prevent the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and protect medical personnel. Increased demands for surgical masks and N95 FFRs during the coronavirus disease 2019 (COVID-19) pandemic has resulted in the shortage crisis. However, there is no standard protocol for safe reuse of the N95 FFRs. In this systematic review, we aimed to evaluate the effectiveness of existing decontamination methods of surgical masks and N95 FFRs and provide evidence-based recommendations for selecting an appropriate decontamination method.Methods:We performed systematic searches of Ovid MEDLINE and Ovid EMBASE electronic databases. The last search was performed April 11, 2020. Any trials studying surgical masks and/or N95 FFRs decontamination were included. Outcomes were disinfections of virus and bacteria, restoration of the filtration efficiency, and maintenance of the physical structure of the mask.Results:Overall, 15 studies and 14 decontamination methods were identified. A low level of evidence supported 4 decontamination methods: ultraviolet (UV) germicidal irradiation (9 studies), moist heat (5 studies), microwave-generated steam (4 studies), and hydrogen peroxide vapor (4 studies). Therefore, we recommended these 4 methods, and we recommended against use were given for the other 10 methods.Conclusions:A low level of evidence supported the use of UV germicidal irradiation, moist heat, microwave-generated steam, and hydrogen peroxide vapor for decontamination and reuse of N95 FFRs. These decontamination methods were effective for viral and bacterial disinfection as well as restoration of the filtration efficiency, and the physical structure of the FFRs.
Microscopic Characterization of Uranium Ore Specimens Using the Peakaboo Analysis Platform
Authors: McIntyre Stewart , Van Loon Lisa , Sherry Nathaniel , Bauer Michael , Kotzer Tom , Banerjee Neil 
Published: July 2020

AbstractXRF maps of a uranium ore sample have been analyzed using software that allows the graphical spatial correlations of all detected elements to be measured. The association of uranium with arsenic, nickel and cesium was explored; all showed unique finely-granular microscopic patterns that could be used to assist the recovery of uranium and rare earths.
Atomic Structure and Dynamics of Defects and Grain Boundaries in 2D Pd2Se3 Monolayers
Authors: Chen Jun , Ryu Gyeonghee , Warner Jamie 
Published: July 2020

AbstractStructural imperfections of 2D crystals such as point vacancies and grain boundaries (GBs) have considerable impacts on their chemical-physical properties. Here we study the atomic structure and dynamics of defects and GBs in monolayer Pd2Se3 using annular dark field scanning transmission electron microscopy (ADF-STEM). The Pd2Se3 monolayers are reproducibly created by thermally induced phase transformation of few-layered PdSe2 films in an in-situ heating holder in the TEM to promote Se loss. Diverse point vacancies, one-dimensional (1D) defects, GBs and defect ring complexes are directly observed in monolayer Pd2Se3, which show a series of dynamics triggered by electron beam. High mobility of vacancies leads to self-healing of point vacancies by migration to the edge and subsequent edge etching under the beam. Specific defects are stabilized by Se–Se bonds, which shift in a staggered way to buffer strain, forming a wave-like 1D defect. Bond rotations are also observed and play an important role in defect and GB dynamics in Pd2Se3 during vacancy production. The GBs form in a meandering pathway and migrate by a sequence of Se–Se bond rotations without large scale vacancy formation. In the GB corners and tilted GBs, other highly symmetric vacancy defects also occur to adapt to the orientation change. These results give atomic level insights into the defects and GBs in Pd2Se3 2D monolayers.
Using IoT to Improve Uptime and Customer Satisfaction
Authors: Schweitzer Marc 
Published: July 2020

AbstractOne of the constant challenges facing managers in central microscopy facilities is the uptime and maintenance of their instruments. Downtime due to performance issues or repairs has a direct negative impact on the operation of the facility, from both a scientific and financial perspective. As vendors, we must commit ourselves to finding new, innovative, and effective ways to mitigate these issues and improve the user experience. This talk will describe one such method: an IoT (Internet of Things) system called Predictive Service used to connect to and monitor the condition of installed microscope instruments. ZEISS has deployed this system to most of their microscope modalities including Light Microscopy (LM), Electron Microscopy (EM) and X-ray Microscopy (XRM). At present, there are over 780 instruments listed worldwide.[i] Implementation of this system has revealed new opportunities and challenges for the Service organization which are being systematically addressed. Although objective data is still being collected, initial reports are promising and show a steady decrease in Mean Time To Repair (MTTR), increased uptime and improved customer satisfaction.
Seismological and Geophysical Signatures of the Deep Crustal Magma Systems of the Cenozoic Volcanic Fields Beneath the Eifel, Germany
Authors: Dahm Torsten , Stiller Manfred , Mechie James , Heimann Sebastian , Hensch Martin , Woith Heiko , Schmidt Bernd , Gabriel Gerald , Weber Michael 
Published: July 2020

AbstractThe Quaternary volcanic fields of the Eifel (Rhineland‐Palatinate, Germany) had their last eruptions less than 13,000 years ago. Recently, deep low‐frequency (DLF) earthquakes were detected beneath one of the volcanic fields showing evidence of ongoing magmatic activity in the lower crust and upper mantle. In this work, seismic wide‐ and steep‐angle experiments from 1978/1979 and 1987/1988 are compiled, partially reprocessed and interpreted, together with other data to better determine the location, size, shape, and state of magmatic reservoirs in the Eifel region near the crust‐mantle boundary. We discuss seismic evidence for a low‐velocity gradient layer from 30–36 km depth, which has developed over a large region under all Quaternary volcanic fields of the Rhenish Massif and can be explained by the presence of partial melts. We show that the DLF earthquakes connect the postulated upper mantle reservoir with the upper crust at a depth of about 8 km, directly below one of the youngest phonolitic volcanic centers in the Eifel, where CO2 originating from the mantle is massively outgassing. A bright spot in the West Eifel between 6 and 10 km depth represents a Tertiary magma reservoir and is seen as a model for a differentiated reservoir beneath the young phonolitic center today. We find that the distribution of volcanic fields is controlled by the Variscan lithospheric structures and terrane boundaries as a whole, which is reflected by an offset of the Moho depth, a wedge‐shaped transparent zone in the lower crust and the system of thrusts over about 120 km length.
The SecA motor generates mechanical force during protein translocation
Authors: Gupta Riti , Toptygin Dmitri , Kaiser Christian M. 
Published: July 2020

AbstractThe Sec translocon moves proteins across lipid bilayers in all cells. The Sec channel enables passage of unfolded proteins through the bacterial plasma membrane, driven by the cytosolic ATPase SecA. Whether SecA generates mechanical force to overcome barriers to translocation posed by structured substrate proteins is unknown. Here, we kinetically dissect Sec-dependent translocation by monitoring translocation of a folded substrate protein with tunable stability at high time resolution. We find that substrate unfolding constitutes the rate-limiting step during translocation. Using single-molecule force spectroscopy, we also define the response of the protein to mechanical force. Relating the kinetic and force measurements reveals that SecA generates at least 10 piconewtons of mechanical force to actively unfold translocating proteins, comparable to cellular unfoldases. Combining biochemical and single-molecule measurements thus allows us to define how the SecA motor ensures efficient and robust export of proteins that contain stable structure.
Unveiling the ferrielectric nature of PbZrO3-based antiferroelectric materials
Authors: Fu Zhengqian , Chen Xuefeng , Li Zhenqin , Hu Tengfei , Zhang Linlin , Lu Ping , Zhang Shujun , Wang Genshui , Dong Xianlin , Xu Fangfang 
Published: July 2020

AbstractBenefitting from the reversible phase transition between antiferroelectric and ferroelectric states, antiferroelectric materials have recently received widespread attentions for energy storage applications. Antiferroelectric configuration with specific antiparallel dipoles has been used to establish antiferroelectric theories and understand its characteristic behaviors. Here, we report that the so-called antiferroelectric (Pb,La)(Zr,Sn,Ti)O3 system is actually ferrielectric in nature. We demonstrate different ferrielectric configurations, which consists of ferroelectric ordering segments with either magnitude or angle modulation of dipoles. The ferrielectric configurations are mainly contributed from the coupling between A-cations and O-anions, and their displacement behavior is dependent largely on the chemical doping. Of particular significance is that the width and net polarization of ferroelectric ordering segments can be tailored by composition, which is linearly related to the key electrical characteristics, including switching field, remanent polarization and dielectric constant. These findings provide opportunities for comprehending structure-property correlation, developing antiferroelectric/ferrielectric theories and designing novel ferroic materials.