bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcomes in Soft Tissue Repair Surgery With and Without Femoral Derotation Osteotomy for Patellar Dislocation: A Retrospective Study
Authors: Fan Chongyi , Yang Guangmin , Niu Yingzhen , Xu Yirong , Li Ming , Feng Xunkai , Wang Fei 
Published: November 2020

Abstract
Background: The purpose of our study was to report the clinical outcomes of isolated soft tissue repair or combined femoral derotation osteotomy (DFO) in patients with patellar dislocation with increased femoral anteversion angle (FAA).Methods: A total of 63 patients with patellar dislocation were retrospectively reviewed in this study. 33 patients received isolated soft tissue repair (group 1) and 30 patients were a combination with a femoral deroration osteotomy (group 2). CT were used to assess the correction of the femoral anteversion angle, the tibia tuberosity-trochlear groove (TT-TG) distance, patellar tilt (PTA), and the congruence angle (CA) following the two surgical programs. Subjective scores, such as Kujala, International Knee Documentation Committee (IKDC), Lysholm ,Tegner, and visual analogue scale (VAS) scores, were used to evaluate knee function.Results: In group 2, the mean of the FAA was corrected to15.76 ±2.02° postoperatively compared with 29.16± 2.87° preoperatively (P < 0.001). The TT-TG distance was decreased from 19.03 ±2.52 mm before surgery to 17.80 ±2.24 mm after surgery (< 0.001). Besides, Postoperative PTA and CA were corrected in both groups (P < 0.001). Kujala, IKDC, Lysholm and VAS scores of between groups were significantly improved after operation (P < 0.001). Furthermore, Compared with the isolated soft tissue repair surgery, the combined surgery achieve better postoperative outcomes in Kujala, (IKDC), Lysholm and VAS scores (P < 0.001). Conclusion: Although DFO can be used in combination with DFO to achieve better results, it should also be tailored to the individual and reduce patient suffering.
Things in the Air: Tagging Wearable IoT Informationon Drone Videos
Authors: Van Lan-Da , Zhang Ling-Yan , Chang Chun-Hao , Tong Kit-Lun , Wu Kun-Ru , Tseng Yu-Chee 
Published: November 2020

Abstract
Drones have been applied to a wide range of security and surveillance applications recently. With drones, Internet of Things are extending to3D space. An interesting question is: Can we conduct person identification(PID) in a drone view? Traditional PID technologies such as RFID and fingerprint/iris/face recognition have their limitations or require close contactto specific devices. Hence, these traditional technologies can not be easily deployed to drones due to dynamic change of view angle and height. In this work,we demonstrate how to retrieve IoT data from users’ and correctly tag themon the human objects captured by a drone camera to identify and track groundhuman objects. First, we retrieve human objects from videos and conduct coordination transformation to handle the change of drone positions. Second,a fusion algorithm is applied to measure the correlation of video data andinertial data based on the extracted human motion features. Finally, we cancouple human objects with their wearable IoT devices, achieving our goal oftagging wearable device data such as personal profiles) on human objects ina drone view. Our experimental evaluation shows a recognition rate of 98.9%.To the best of our knowledge, this is the first work integrating videos fromdrone cameras and IoT data from inertial sensors.
Albumin Platelet Product: A Novel Score for Liver Fibrosis Stage and Prognosis.
Authors: Fujita Koji , Yamasaki Kazumi , Morishita Asahiro , Shi Tingting , Tani Joji , Nishiyama Noriko , Kobara Hideki , Himoto Takashi , Yatsuhashi Hiroshi , Masaki Tsutomu 
Published: November 2020

Abstract
Fibrosis-4 index, a conventional biomarker for liver fibrosis stage, is confounded by age and hepatitis activity grade . The current retrospective multicenter study aimed to formulate the novel indices of liver fibrosis by mathematically combining items of peripheral blood examination and to evaluate ability of prognosis prediction. After a novel index was established in a training cohort, the index was tested in a validation cohort. Briefly, a total of 426 patients were enrolled in a training cohort. Albumin and platelet most strongly correlated to fibrosis stage among blood examination. Albumin platelet product (APP) = Albumin × platelet / 1000 could differentiate the four stages of liver fibrosis (p < 0.05). APP indicated fibrosis stage independent from hepatitis activity grade. A cut-off value = 4.349 diagnosed cirrhosis with area under ROC more than 0.8. Multivariate analysis revealed that smaller APP independently contributed to HCC prevalence and overall mortality. The results were validated in another 707 patients with HCV infection. In conclusion, APP was not confounded by age or hepatitis activity grade contrary to Fibrosis-4 index. APP is as simple as physicians can calculate it by pen calculation. The product serves physicians in managing patients with chronic liver disease.
The Rural Tax: Out-of-Pocket Costs for Patient Travel in British Columbia
Authors: Kornelsen Jude , Khowaja Asif , Av-gay Gal , Sullivan Eva , Parajulee Anshu , Dunnebacke Marjorie , Egan Dorothy , Balas Mickey , Williamson Peggy 
Published: November 2020

Abstract
Background: A significant concern for rural patients is the cost of travel outside of their community for specialist and diagnostic care. Often, these costs are downloaded to patients and their families. Methods: Online retrospective provincial survey seeking to estimate the out-of-pocket (OOP) costs and associated experiences of rural patients traveling to access health care in British Columbia. Respondents were surveyed across five categories: Distance Traveled and Transportation Costs, Accommodation Costs, Co-Traveler Costs, Lost Wages, and Patient Stress. Results: On average, costs for respondents were $777 and $674 for transport and accommodation, respectively. Patient perspectives obtained from this survey expressed a number of related issues, including the physical and psychosocial impacts of travel as well as delayed or diminished care seeking. Conclusions: These key findings highlight the existing inequities between rural and urban patient access to health care. This study can directly inform policy related efforts towards mitigating the rural-urban gap in access to health care.
Comprehensive Analysis and Expression Profiling of PIN, AUX/LAX, and ABCB Auxin Transporter Gene Families in Solanum tuberosum under Phytohormone Stimuli and Abiotic Stresses
Authors: Yang Chenghui , Wang Dongdong , Zhang Chao , Ye Minghui , Kong Nana , Ma Haoli , Chen Qin 
Published: November 2020

Abstract

Background:Auxin is the only plant hormone that exhibits transport polarity that is mediated by three classes of proteins, AUX/LAX influx carriers, the PIN and ABCB efflux carriers. Extensive studies have been conducted to examine the biological functions of auxin transporter genes using model plants systems and in several plant species. Despite this, information regarding the comprehensive analysis of auxin transporter genes in potato species and information regarding the expression patterns of these genes in response to external stresses remains scarce.Results: Here, we conducted a genome-wide annotation of the StLAX, StPIN, and StABCB auxin transporter gene families to examine genomic distributions, gene structures, phylogenic relationships and co-expression analysis. From these analyses, 5 StLAXs, 10 StPINs, and 22 StABCBs were identified in the potato genome and mapped to 12 chromosomes. Constructing co-expression networks revealed 18 gene modules and potato auxin transporter genes distributed in ten of them correlating to the development of various tissues. Tissue-specific expression analysis indicated that genes from the StLAX family were expressed at significantly higher levels compared to those of the other two gene families, suggesting that the StLAXs may be more important for these designated developmental stages in potato. Quantitative real-time PCR analysis indicated responsiveness of StLAXs, StPINs, and StABCBs to auxin and PATIs, implying their possible roles in mediating intercellular auxin homoeostasis and redistribution. Additionally, the differential expression levels of the StLAX, StPIN, and StABCB genes under ABA and abiotic stresses were indicative of their specific adaptive mechanisms regulating tolerance to various environmental stimuli. Promoter cis-regulatory element analyses were used to explore a large number of auxin-responsive and stress-related cis-elements within the promoters of the StLAX, StPIN, and StABCB genes that could account for their responsiveness to diverse stresses.Conclusions: In summary, we have provided comprehensive information on StLAX, StPIN, and StABCB auxin transporter gene families in potato. We are confident that our results provide a foundation for a better understanding of auxin transport in potato, as we have demonstrated the biological significance of these family genes in hormone signalling and adaption to environmental stresses.
A Roadmap to Inform the Implementation of Evidence-Based Collaborative Care Interventions in Communities: Insights From the Michigan Mental Health Integration Partnership
Authors: Rusch Amy , DeCamp Lindsay , Liebrecht Celeste , Choi Seo Youn , Dalack Gregory W , Kilbourne Amy M , Smith Shawna N 
Published: November 2020

Abstract
BackgroundIn spite of increasing calls for further spread of evidence-based collaborative care interventions (EBIs) in community-based settings, practitioner-driven efforts are often stymied by a lack of experience in addressing barriers to community-based implementation, especially for those not familiar with implementation science. The Michigan Mental Health Integration Partnership (MIP) is a statewide initiative that funds projects that support implementation and uptake of EBIs in community-based settings. MIP also provides an in situ implementation laboratory for understanding barriers to the uptake of EBIs across a variety of settings. We report findings from a Statewide qualitative study of practitioners involved in MIP projects to garner their perspectives of best practices in the implementation of EBIs. MethodsTwenty-eight semi-structured interviews of practitioners and researchers from six MIP Projects were conducted with individuals implementing various MIP EBI projects across Michigan, including stakeholders from project teams, implementation sites, and the State of Michigan, to identify common barriers, challenges, and implementation strategies deployed by the project teams, with the purpose of informing a set of implementation steps and milestones. ResultsStakeholders identified a number of barriers to and strategies for success, including the need for tailoring program deployment and implementation to specific site needs, development of web-based tools for facilitating program implementation, and the importance of upper level administration buy-in. Findings informed our resultant community-based Implementation Roadmap, which identifies critical steps across three implementation phases--pre-implementation, implementation, and sustainability—for implementation practitioners to use in their EBI implementation efforts. ConclusionImplementation practitioners interested in community-based EBI implementation often lack access to operationalized implementation “steps” or “best practices” that can facilitate successful uptake and evaluation. Our community-informed MIP Implementation Roadmap, offering generalized steps for reaching successful implementation, uses experiences from a diverse set of MIP teams to guide practitioners through the practices necessary for scaling up EBIs in community-based settings over pre-implementation, implementation and sustainability phases.
The Role of α-Smooth Muscle Actin in Confirming the Microinvasion of Laryngeal Squamous Cell Carcinoma
Authors: Bai Yuping , Yue Changli , Lu Zhichun , Liu Honggang 
Published: November 2020

Abstract
BackgroundThe diagnosis of microinvasive laryngeal squamous cell carcinoma (mLSCC) is not always straightforward and sometimes can be very challenge in daily clinical practice, particularly in the circumstances with differentials such as SIL with inverted growth pattern and PEH. The focus of the diagnosis is the confirmation of microinvasion. Cancer-associated fibroblasts (CAFs), as the major element of tumor microenvironment, are believed to participate actively in the invasion of tumor cells. In this study, we sought to evaluate the diagnostic role of α-SMA labelling CAFs in mLSCC, with comparison of laryngeal squamous intraepithelial lesion (SIL) and benign pseudoepitheliomatous hyperplasia (PEH).MethodsA total of 81 laryngeal biopsy specimens were retrieved, including 41 cases of mLSCC with depth of invasion no more than 3 mm, 20 laryngeal SIL, and 20 PEH. All tissues were stained for immunohistochemistry, using antibody against the α-SMA antigen. We observed the presence of α-SMA positive fibroblasts in mLSCC, compared the results with that of laryngeal SIL and benign PEH by Chi-square statistics test, and investigated the correlation between tumor histological characteristics and the presence of CAFs in mLSCC.ResultsImmunoreactivity of α-SMA was detected in twenty-nine mLSCC (29/41, 70.7%), while no reactivity was observed in laryngeal SIL (0/20, 0%), and few in PEH (2/20, 10%). The α-SMA expression pattern in stromal fibroblasts of mLSCC were significantly different from those of SIL (χ2￼ = 26.966, p=0.000) and PEH (χ2￼ = 19.838, p=0.000). This support that, α-SMA as an immunolabeling of CAFs plays a reliable role in confirming the microinvasion of LSCC. In addition , we finds that there is dense lymphoplasmacytic infiltration in the stroma of a few mLSCC (7/41, 17.1% ) cases rather than tumor-related desmoplastic hyperplasia. And it seems that there is a negative correlation between dense lymphoplasmacytic infiltration and the presence of CAFs in LSCC.ConclusionsOur study highlights practical role of utilizing α-SMA in the diagnosis of microinvasive laryngeal squamous cell carcinoma, with emphasis on variable histomorphologic features of mLSCCs.
Screening for Familial Hypercholesterolemia in Small Towns: Experience from 11 Brazilian Cities at the HipercolBrasil Program
Authors: Jannes Cinthia Elim , Silvino Júnea Paolucci.Paiva , Silva Pãmela Rodrigues de Souza , Lima Isabella Ramos , Tada Mauricio Teruo , Oliveira Théo Gremen Mimary , Santos Raul Dias , Krieger Jose Eduardo , Pereira Alexandre da Costa 
Published: November 2020

Abstract
Background: Familial hypercholesterolemia is an autosomal dominant disease clinically characterized by elevated serum levels of low density lipoprotein-cholesterol (LDL-C) and associated with the occurrence of early atherosclerotic cardiovascular disease. In Brazil, HipercolBrasil, currently the largest screening program underway, exists since 2012 and has already identified more than 2000 individuals with causal genetic variants for FH. The standard approach of HipercolBrasil is based on cascade-screening of refereed index cases, hypercholesterolemic individuals with a clinical suspicion of FH. Methodology: to assess a new methodology for identifying new individuals with genetic alterations for FH we performed a comprehensive city-wide screening in 11 small Brazilian cities (up to 60 thousand inhabitants). The selection of cities occurred in 3 ways: 1) cities with suspicious founder effect (4 cities); 2) Cities in a region with high rates of dyslipidemic individuals as described by the National Health System database (DATASUS) (2 cities); and 3) Cities geographically close to other cities with a high incidence of individuals with FH (5 cities). Results: One-hundred and five (105) index cases and 409 first-degree relatives were enrolled. The yield of such approach was significantly better than the general HipercolBrasil positivity rate in molecular screening. We identified 36 IC with a pathogenic or likely-pathogenic variants for FH and 240 affected first-degree relatives. Conclusion: our data suggest that once detected, specific geographical regions warrant a target approach for the identification of clusters of FH individuals.
Analysis of PET Parameters Predicting Response to Radiotherapy for Myeloid Sarcoma
Authors: Choi Kyu Hye , Song Jin Ho , Kwak Yoo-Kang , Park Eun Young , Lee Jong Hoon , Jang HongSeok 
Published: November 2020

Abstract
Background: Positron-emission tomography (PET)-CT has recently been used for diagnostic imaging and radiotherapy for myeloid sarcoma, but there is little research on predicting the response of radiotherapy. The aim of this study was to analyze the association between PET-CT variables and the response to radiotherapy in patients with myeloid sarcoma.Methods: This study was conducted in myeloid sarcoma patients who received radiotherapy and PET-CT before and after radiotherapy. The response to radiotherapy was evaluated based on the European Organization for Research and Treatment of Cancer PET response criteria, and binary regression analysis was performed to assess the factors predicting reductions in the SUVmax.Results: Twenty-seven sites in 12 patients were included in the study. The 27 irradiated sites included 14 soft tissues, 11 bones, and two organs. Complete metabolic responses were seen in 24 patients after radiotherapy, a partial metabolic response in one, and progressive metabolic disease in two patients. The prescribed dose of more than 3000 cGy10 was significantly greater in the treatment control group (P = 0.024). In binary logistic regression analysis predicting reductions in the SUVmax of more than 70% after radiotherapy, the pretreatment SUVmax (≥ 7.5) and further chemotherapy after radiotherapy showed significant differences in univariate and multivariate analyses.Conclusions: Good metabolic responses (complete or partial) to radiotherapy were achieved in 92.6% of the myeloid sarcoma patients. Radiation doses < 3000 cGy10 and increased SUVmax were related to treatment failure and high SUVmax before radiotherapy was a factor influencing SUVmax reduction. Further large-scale studies are needed.
Knowledge-based Planning using Pseudo-structures for Volumetric Modulated arc Therapy (VMAT) of Postoperative Uterine Cervical Cancer: A Multi-Institutional Study
Authors: Kamima Tatsuya , Ueda Yoshihiro , Fukunaga Jun-ichi , Tamura Mikoto , Shimizu Yumiko , Muraki Yuta , Yoshioka Yasuo , Kitamura Nozomi , Nitta Yuya , Otsuka Masakazu , Monzen Hajime 
Published: November 2020

Abstract
Background: The aim of this study was to investigate the performance of the RapidPlan knowledge-based treatment planning system using models including registered pseudo-structures, and to determine how many structures are required for automatic optimization of volumetric modulated arc therapy (VMAT) for postoperative uterine cervical cancer. Methods: Pseudo-structures were retrospectively contoured for patients who had completed treatment at one of five institutions. For 22 patients, RPs were generated with a single optimization for models with two (RP_2), four (RP_4), or five (RP_5) registered structures, and the dosimetric parameters of these models were compared with a clinical plan with several optimizations. The total times for pseudo-structure creation and optimization were also measured.Results: Most dosimetric parameters showed no major differences between each RP. In particular, the rectum Dmax, V50Gy, and V40Gy with RP_2, RP_4, and RP_5 were not significantly different, and were lower than those of the clinical plan. In addition, the average proportions of plans achieving acceptable criteria for all dosimetric parameters were 98%, 99%, 98%, and 98% for the clinical plan, RP_2, RP_4, and RP_5, respectively. The average times for the creation and optimization of pseudo-structures were 105, 17, 21, and 29 minutes, for the clinical plan, RP_2, RP_4, and RP_5, respectively. Conclusions: The RapidPlan model with two registered pseudo-structures could generate clinically acceptable plans while saving time. This modeling approach using pseudo-structures could possibility be used for the VMAT planning process.
Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria
Authors: Watanabe Kenji , Tsunematsu Yuta , Hosomi Koji , Kunisawa Jun , Sato Michio , Shibuya Noriko , Saito Emiko , Murakami Haruka , Yoshikawa Yuko , Iwashita Yuji , Miyoshi Noriyuki , Mutoh Michihiro , Ishikawa Hideki , Sugimura Haruhiko , Miyachi Motohiko , Wakabayashi Keiji 
Published: November 2020

Abstract
While colibactin-producing Escherichia coli is linked to colorectal oncogenesis, its infection route remains poorly characterized. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding. This finding suggests the possibility of developing early preventive measures against colorectal cancer.
Difference in Gender Perception Regarding Smokeless Tobacco; A Cross Sectional Survey from Karachi Pakistan
Authors: Iqbal NOUSHEEN , Sheikh Muhammad Dawood Amir , Riaz Urooj , Irfan Muhammad , Awan Safia , Khan Muhammad Waqas , Bana Sohail , Khan Javaid 
Published: November 2020

Abstract
BackgroundSmokeless tobacco (SLT) consumption is high in south Asia where it is a leading cause of head and neck cancer. However, limited data available on the perception of SLT consumption among males and females. Methods A cross-sectional survey was conducted from October to December 2018 in five major hospitals of Karachi Pakistan. All male and female, using SLT were first identified through random convenient sampling and then interviewed, 500 participants were approached and 455 were consented to participate in the study. ResultsOut of 455, 286(61.9%) were male, the mean age was 36.8±13.4 years. Among them 97(34%) males and 3(1.8%) females were also using cigarettes. Major reason for starting SLT among women was the norm of family 56(33%) followed by emotional stress relief 53(31%), while among male 69 (24%) started for emotional stress relief followed by the curiosity of trying something new in 59 (20.6%).Both male 205(71.7%) and female 130(76.9%) think it is less harmful then smoking while 44% (127) male and 63(37%) female think its bed for health. Only 100(35%) of men and 71(42%) of women believed that SLT use could cause cancer. Conclusion Smokeless tobacco is considered as less harmful among males and females. Social acceptability was also found to be common. Awareness regarding the harmful effect of SLT is required among both males and females.