bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interbody Fusion and Percutaneous Reduction For Lumbar Spondylolisthesis With Mobile Microendoscopic Discectomy Technique
Authors: Xu Baoshan , Xu Haiwei , Zhang Hao , Ma Xinlong , Liu Yue , Yang Qiang , Jiang Hongfeng , Ji Ning , Li Ning 
Published: February 2020

Study Design:
A minimally invasive surgical technique for lumbar spondylolisthesis.

Objective:
The objective of this study was to investigate the feasibility and clinical efficacy of interbody fusion and percutaneous reduction for lumbar spondylolisthesis using mobile microendoscopic discectomy (MMED) technique.

Summary of Background Data:
Current surgical techniques for lumbar spondylolisthesis cause considerable trauma, so a minimally invasive technique is needed.

Materials and Methods:
A total of 62 patients of lumbar spondylolisthesis (40 patients of degenerative spondylolisthesis and 22 patients of isthmic spondylolisthesis) were treated with interbody fusion and percutaneous reduction using the MMED technique. A 2.5-cm longitudinal incision was made on the side of dominant symptoms, with paraspinous approach used for degenerative spondylolisthesis and transforaminal approach for isthmic spondylolisthesis. The fenestration and decompression were performed under MMED. The intervertebral space was released through an outer tube under direct vision, followed by bone graft and cage implantation. Percutaneous pedicle screws were used, with the residual spondylolisthesis further reduced. The patients were followed up to evaluate the clinical results.

Results:
The procedure was successful in all patients. Postoperative radiographs showed sufficient decompression and improvement of spinal alignment for both groups. The average reduction rate of the spondylolisthesis was 68% for degenerative spondylolisthesis group and 66% for isthmic spondylolisthesis group. The patients of 2 groups were followed up for 12–24 months. At the final follow-up, the Oswestry Disability Index and Visual Analogue Scale scores decreased significantly compared with preoperation for both groups. The clinical results were excellent in 22 cases, good in 16 and fair in 2 for degenerative spondylolisthesis group, and excellent in 11 cases, good in 10 and fair in 1 for isthmic spondylolisthesis group according to the Macnab Scale.

Conclusion:
Interbody fusion and percutaneous reduction with MMED provides a minimally invasive procedure for lumbar spondylolisthesis, with sufficient decompression, reduction, fusion, and satisfactory clinical results.
Taking a fresh look at mood, hormones, and menopause
Authors: Soares Claudio N. 
Published: February 2020

Abstract
Depression, with or without concomitant anxiety, is one of the most burdensome medical conditions worldwide. Depression affects women more often than men and may cause significant impairment. Reproductive phase-related windows of vulnerability for depression (new or recurrent) have been recognized, including the menopause transition. Midlife depression is likely influenced by both menopause- and nonmenopause-related factors. Antidepressants and cognitive behavioral therapy remain first-line treatment options for moderate to severe major depressive disorder at any time, with proven efficacy and tolerability in midlife women. Transdermal estradiol can also be part of the treatment armamentarium, but its use as a prophylaxis against midlife depressive symptoms, although promising, warrants further investigation.
A phase 2b, randomized, placebo-controlled, double-blind, dose-ranging study of the neurokinin 3 receptor antagonist fezolinetant for vasomotor symptoms associated with menopause
Authors: Fraser Graeme L. , Lederman Samuel , Waldbaum Arthur , Kroll Robin , Santoro Nanette , Lee Misun , Skillern Laurence , Ramael Steven 
Published: February 2020

Abstract

Objective:
Menopausal vasomotor symptoms (VMS) may result from altered thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing neurons. This phase 2b study evaluated seven dosing regimens of fezolinetant, a selective neurokinin 3 receptor antagonist, as a nonhormone approach for the treatment of VMS.

Methods:
Menopausal women aged >40-65 years with moderate/severe VMS (≥50 episodes/wk) were randomized (double-blind) to fezolinetant 15, 30, 60, 90 mg BID or 30, 60, 120 mg QD, or placebo for 12 weeks. Primary outcomes were reduction in moderate/severe VMS frequency and severity ([number of moderate VMS × 2] + [number of severe VMS × 3]/total daily moderate/severe VMS) at weeks 4 and 12. Response (≥50% reduction in moderate/severe VMS frequency) was a key secondary outcome.

Results:
Of 352 treated participants, 287 completed the study. Fezolinetant reduced moderate/severe VMS frequency by −1.9 to −3.5/day at week 4 and −1.8 to −2.6/day at week 12 (all P < 0.05 vs placebo). Mean difference from placebo in VMS severity score was −0.4 to −1 at week 4 (all doses P < 0.05) and −0.2 to −0.6 at week 12 (P < 0.05 for 60 and 90 mg BID and 60 mg QD). Response (50% reduction) relative to placebo was achieved by 81.4% to 94.7% versus 58.5% of participants at end of treatment (all doses P < 0.05). Treatment-emergent adverse events were largely mild/moderate; no serious treatment-related treatment-emergent adverse events occurred.

Conclusions:
Fezolinetant is a well-tolerated, effective nonhormone therapy that rapidly reduces moderate/severe menopausal VMS.

Video Summary:
http://links.lww.com/MENO/A572; video script available at http://links.lww.com/MENO/A573.
Seasonal blood pressure variation assessed by different measurement methods: systematic review and meta-analysis
Authors: Kollias Anastasios , Kyriakoulis Konstantinos G. , Stambolliu Emelina , Ntineri Angeliki , Anagnostopoulos Ioannis , Stergiou George S. 
Published: February 2020

Objective:
The current study reviewed the published evidence on the seasonal changes in blood pressure (BP) assessed using different measurement methods.

Methods:
A systematic PubMed/EMBASE search was performed for studies assessing seasonal BP changes. Prospective and cross-sectional studies were included fulfilling the following criteria: (i) report of ambulatory and/or home BP data; (ii) cross-sectional studies reporting only office BP measurements and including 1000 or more participants.

Results:
Forty-seven studies fulfilled the selection criteria and were included (856 539 participants, weighted age 49.7 ± 4.8 years, 38.8% treated hypertensive patients). The pooled summer minus winter SBP/DBP difference (95% confidence intervals) was office BP (29 studies) −5.6 (−7.1, −4.0)/−3.3 (−4.0, −2.7) mmHg; daytime ambulatory BP (15 studies) −3.4 (−4.4, −2.4)/−2.1 (−2.8, −1.4) mmHg; night-time ambulatory BP (13 studies) 1.3 (0.2, 2.3)/0.5 (−0.2, 1.2) mmHg; home BP (9 studies) −6.1 (−7.0, −5.1)/−3.1 (−3.5, −2.6) mmHg. Meta-analysis of 28 prospective studies (N = 5278) which examined the same individuals during different seasons showed pooled seasonal SBP/DBP difference: office BP −5.8/−4.0 mmHg; daytime ambulatory BP −3.9/−2.7 mmHg; night-time ambulatory BP 0.5/−0.5 mmHg; home BP −6.4 /−3.3 mmHg. In meta-regression analysis seasonal systolic daytime ambulatory BP difference was related to the percentage of treated hypertensive patients across studies (P = 0.02) and borderline to age (P = 0.07).

Conclusion:
Seasonal BP changes are evident using all daytime BP measurement methods, but not with night-time ambulatory BP. The average BP decline in hot season is at about 5/3 (SBP/DBP) mmHg and appears to be larger in treated hypertensive patients and in older individuals.
Preventing forgotten double J ureteral stents in a high-volume service medical center: An autoregistration monitoring system
Authors: Lin Kuan-Jung , Chen Ping-Chi , Fan Yu-Hua , Huang William J.S. 
Published: February 2020

Background:
To evaluate the efficacy of an autoregistration monitoring system (ARMS) for tracking the placement and removal of ureteral stents.

Methods:
The system was designed to tie in closely with the billing system. Once a stent was used and charged, a stent “episode” was created in the ARMS. When the stent was removed and the charge for the procedure was issued, the stent episode for that stent was removed automatically. The ARMS identified stents which exceeded their deadline, generating an alarm until the stent was removed and the ARMS updated.

Results:
A total of 10 105 patients with 12 440 stent episodes were registered in the ARMS between March 2010 and August 2018. Of the 10 105 patients, 8597 (85.07%) were automatically detected to have had their stents removed before their deadline. We contacted the 1508 (14.93%) patients whose stents were not registered as having been removed by their deadline, of whom 122 (1.21%) had undergone stent removal at other hospitals, 490 (4.85%) had died, and 875 (8.66%) knew that they had ureteral stents inserted and were urged to come back for stent removal. Twenty-one patients (0.21%) did not know that they had implanted stents. None of these 21 patients were urological patients, and they had stents placed during urological consultation in an operating room.

Conclusion:
Our study showed that the ARMS reduced the manpower in tracking stent removal by 85.07% and that it was useful for detecting and preventing forgotten stents.
A Randomized Controlled Trial on Optimal Sampling Sequence in Radial Guide Sheath Endobronchial Ultrasound Lung Biopsy
Authors: Samaranayake Chinthaka B. , Wright Craig , Erigadoo Shiv , Azzopardi Maree , Putt Michael , Bint Michael 
Published: February 2020

Background:
An optimal sampling sequence in radial guide sheath endobronchial ultrasound lung biopsy (R-EBUS) is unclear. This prospective single-center pilot randomized controlled trial aimed to determine if the initial method and sequence of sampling affect the diagnostic accuracy of the procedure.

Methods:
Consecutive patients undergoing R-EBUS for lesions >15 mm with a bronchus sign were randomly assigned (1:1:1) to biopsy first (group A), brushings first (group B) or combination (group C). The primary outcome was a positive diagnosis from any sampling method.

Results:
Fifty-four patients were randomized. The overall diagnostic yield of the procedure was 77.8% (95% confidence interval: 66%-89%), with no difference between groups. A higher rate of positive cytology from brushings was seen if the biopsies were performed before brushings (77.8% in group A vs. 44.4% in group B, P=0.03). The rate of positive cytology from washings was higher if the washings were obtained just after the brushings (61.1% in group A vs. 11.1% in group B, P=0.02). There was no difference in the rate of positive biopsy histology in the groups (P=0.27). All 3 sampling modalities were more likely to be positive in group A (50.0% vs. 11.1% in group B and 22.2% in group C, P=0.04). Complications rate was low and not significantly different between groups.

Conclusion:
The overall rate of a positive R-EBUS procedure was not affected by the initial sampling method or sequence. However, all 3 sampling modalities were more likely to be positive if biopsies were performed first, followed by brushings and washings.
Transbrow Excision Blepharoplasty for Upper Eyelid Dermatochalasis: A Modified Approach
Authors: Lv Qianwen , Liu Zhenjun , Gu Yunpeng , Qi Yue , Ma Gui-e 
Published: February 2020

Backgrounds:
Many aging women with upper lid dermatochalasis pluck their lower lateral eyebrows to combat lateral drooping. The authors present and evaluate outcomes of a modified excision blepharoplasty method performed using a transbrow excision approach instead of infra/suprabrow access to more efficiently correct upper eyelid dermatochalasis.

Methods:
The authors conducted a retrospective review of 192 patients who underwent transbrow excision blepharoplasty (TBEB) between 2014 and 2019 at the Plastic Surgery Hospital of Beijing in China. The clinical features, complications, and outcomes of patients were reviewed. The Strasser grading system was used to evaluate surgical results postoperatively. Aesthetic improvement was subjectively judged by the patients.

Results:
All 192 patients (aged 25–72 years old, mean 46 years old) were reviewed and followed up for 6 months to 2 years. Patients were evaluated after 1 week and after at least 6 months. All patients reported an improved aesthetic appearance of the lateral periorbital area, and 174 patients (90.6%) rated their results as satisfactory. No serious complications were related to the procedure.

Conclusions:
TBEB is used to correct problems that are not adequately managed by conventional excision blepharoplasty. Among 192 patients evaluated over 5 years, excision of the transbrow skin pad sufficiently reduced the redundancy of the upper eyelid and achieved an acceptable appearance of the periorbital area, where the postoperative location of a subtle scar defined a desired youthful brow position. In selected patients, this is an effective and safe method that uses patient-observed features to provide an alternate cosmetic approach.
Early cognitive impairment is common after intracranial hemorrhage with mild traumatic brain injury
Authors: Delaplain Patrick T. , Albertson Spencer , Grigorian Areg , Williams Barbara , Smith Megan , Inaba Kenji , Lekawa Michael , Nahmias Jeffry 
Published: February 2020

BACKDROP
The incidence of early cognitive impairment (ECI) after traumatic brain injury (TBI) is unknown. We hypothesized ECI is common and can be predicted based on Glasgow Coma Scale (GCS) and Brain Injury Guideline (BIG) category.

METHODS
A single-center, retrospective review of adult trauma patients (2014–2016) with intracranial hemorrhage (ICH) and mild TBI (GCS score, 13–15) was performed. The primary outcome was ECI, defined as a Rancho Los Amigos score less than 8. Routine cognitive evaluation is performed on all ICH patients at our institution. Comparisons between ECI and no-ECI groups regarding demographic, cognitive, and clinical outcomes were evaluated using bivariate statistics. The odds of ECI were evaluated using a multivariable logistic regression.

RESULTS
There were 465 patients with mild TBI, 70.3% were male, and the average age was 53 ± 23 years. The most common mechanism of injury was fall (41.1%) followed by motor vehicle collision (15.9%). The incidence of ECI was 51.4% (n = 239). The incidence in patients with a GCS score of 15 was 42.9%, and BIG 1 category was 42.7%. There were no differences in demographics (age, sex, comorbidities), mechanism of injury, or imaging when comparing ECI patients with no-ECI patients. The GCS score was lower in the ECI group (14.4 vs. 14.7, p < 0.001). Patients with ECI were also less likely to be discharged home (58.2% vs. 78.3%, p < 0.001). Lower GCS-verbal, BIG category 3, and presence of pelvic/extremity fractures were strong risk factors for ECI in a logistic regression model adjusted for age, loss of consciousness, anticoagulants, narcotic administration, and Rotterdam score.

CONCLUSION
Half of all patients with ICH and mild TBI had ECI. Both lower initial GCS score and BIG category 3 were associated with increased likelihood of ECI. Therefore, we recommend all patients with ICH and mild TBI undergo cognitive evaluation.

LEVEL OF EVIDENCE
Prognostic Study, Level III.
2019 Novel Coronavirus can be detected in urine, blood, anal swabs and oropharyngeal swabs samples
Authors: Peng Liang , Liu Jing , Xu Wenxiong , Luo Qiumin , Deng Keji , Lin Bingliang , Gao Zhiliang 
Published: February 2020

AbstractWe tested samples collected from nine patients diagnosed with coronavirus disease 2019 (COVID-19). The virus was found in urine, blood, anal swabs and oropharyngeal swabs. It is the first time for SARS-CoV-2 found in urine, though no urinary irritation was found.
Compensatory word of mouth as symbolic self-completion
Authors: Saenger Christina , Thomas Veronica L. , Bock Dora E. 
Published: February 2020

Purpose
When consumers experience a self-threat that calls their self-concept into question, the ensuing psychological discomfort motivates them to restore their self-perceptions on the threatened attribute. Although consumers can restore a threatened self-perception by consuming products and brands that possess the desired symbolic associations, this study aims to propose that word of mouth can serve to resolve self-threat and restore a threatened self-perception when the brand at the center of a word-of-mouth communication is symbolically congruent with the domain of the threat.

Design/methodology/approach
Experimental online survey research was conducted, inducing self-threat, manipulating brand and word-of-mouth conditions and measuring self-perceptions. Data for three studies were analyzed using SPSS and Hayes’ (2013) PROCESS macro.

Findings
Three studies show that spreading word of mouth can restore consumers’ threatened self-perceptions when the brand is symbolically congruent with the threat domain. Word of mouth about a symbolically congruent brand alleviates psychological discomfort, resulting in higher self-perceptions on the threatened attribute. The restorative effect is amplified for lower self-esteem consumers.

Research limitations/implications
Participants in the focal conditions were required to spread word of mouth, which may not be an organic response for all consumers; although not spreading word of mouth is ineffective, other compensatory consumer behavior options exist. The brand option was provided to participants, which allowed for control but may have reduced some of the realism.

Practical implications
Positioning brands to meet consumers’ psychological needs encourages the development of consumer–brand attachments. Brands that resonate with consumers reap the benefits of consumers’ active loyalty behaviors and enjoy stronger brand equity. The present research implies a new way consumers can form brand attachments: by spreading word of mouth to resolve self-threat. As many consumers post detailed, personal information online, this research suggests firms can align their brand messages with relevant identity-related discrepancies.

Originality/value
This research extends the symbolic self-completion compensatory consumption strategy to the word-of-mouth context, showing that consumers can achieve the same restorative effect as consumption by spreading word of mouth. This research also contributes to compensatory word-of-mouth literature by establishing the role of brand meaning.
Integrated reporting, financial reporting quality and cost of debt
Authors: Muttakin Mohammad Badrul , Mihret Dessalegn , Lemma Tesfaye Taddese , Khan Arifur 
Published: February 2020

PurposeAlthough proponents of integrated reporting (IR) advocate that this emerging practice has the potential to transform corporate reporting, the eventuation of this expectation would depend on the incentive IR provides to firms. This study aims to examine whether IR is associated with cost of debt and whether IR moderates the relationship between financial reporting quality and cost of debt.Design/methodology/approachBased on insights drawn from information asymmetry and agency theories, the authors develop models that link IR and financial reporting quality with a firm’s cost of debt. The authors analyze 847 firm-year observations drawn from non-financial firms traded on the Johannesburg Stock Exchange, for the period between 2009 and 2015.FindingsThe authors find that firms that provide integrated reports tend to have a lower cost of debt than those do not provide IR. The authors also find an inverse association between financial reporting quality and cost of debt, and that integrated reports accentuate this association. The findings suggest that the debt market perceives value in the information presented in integrated reports beyond what is furnished in financial reports.Originality/valueTo the best of the authors’ knowledge, this study is the first to document evidence suggesting that the debt market perceives value in the information presented in integrated reports, beyond what is furnished in financial reports.
Repeated presentation of children and adolescents to the emergency department following self‐harm: A retrospective audit of hospital data
Authors: Summers Peter , O'Loughlin Rachel , O'Donnell Sinead , Borschmann Rohan , Carlin John , Hiscock Harriet 
Published: February 2020

AbstractObjectiveTo examine re‐presentation rates for self‐harm in patients aged 0–18 years to the ED of a tertiary paediatric hospital in Melbourne, Australia, and associated patient, family and hospital presentation factors.MethodsData for presentations from 1 July 2016 to 31 December 2018 were extracted from the hospital's electronic medical record system. Self‐harm presentations were identified through automated, rule‐based coding and manual review of medical notes. Re‐presentation rates for intervals up to 12 months were estimated using survival methods with risk factor associations examined using Cox regression.ResultsOf the 952 presentations for self‐harm after 1 January 2017, 529 were considered first presentations. An estimated 15% (95% confidence interval [CI] 12–19), 20% (95% CI 17–24) and 23% (95% CI 19–27) re‐presented for self‐harm within 3, 6 and 12 months, respectively. A total of 82% of all presentations were for girls. Patients were more likely to re‐present if they had previously presented more than once, were flagged as vulnerable (hazard ratio [HR] 1.35, 95% CI 1.08–1.68), had a history of substance abuse (HR 1.30, 95% CI 1.03–1.64), were female (HR 1.43, 95% CI 0.92–2.21), had self‐cut (HR 1.38, 95% CI 0.96–1.97), had an aggressive behaviour response team called during the visit (HR 1.44, 95% CI 0.85–2.45) or had a history of depression (HR 1.27, 95% CI 0.99–1.63).ConclusionsIn this paediatric ED, almost one in four patients re‐presented with self‐harm within 12 months. Previous presentations and other factors were associated with risk of re‐presenting, although no factor was strongly predictive. Future research might examine the generalisability of these findings across settings and explore strategies for prevention.
C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis
Authors: Wang Mingmei , Wang Hongfeng , Tao Zhouteng , Xia Qin , Hao Zongbing , Prehn Jochen H. M. , Zhen Xuechu , Wang Guanghui , Ying Zheng 
Published: February 2020

AbstractGGGGCC repeat expansion in C9orf72 is the most common genetic cause in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two neurodegenerative disorders in association with aging. Bidirectional repeat expansions in the noncoding region of C9orf72 have been shown to produce dipeptide repeat (DPR) proteins through repeat‐associated non‐ATG (RAN) translation and to reduce the expression level of the C9orf72 gene product, C9orf72 protein. Mechanisms underlying C9orf72‐linked neurodegeneration include expanded RNA repeat gain of function, DPR toxicity, and C9orf72 protein loss of function. In the current study, we focus on the cellular function of C9orf72 protein. We report that C9orf72 can regulate lysosomal biogenesis and autophagy at the transcriptional level. We show that loss of C9orf72 leads to striking accumulation of lysosomes, autophagosomes, and autolysosomes in cells, which is associated with suppressed mTORC1 activity and enhanced nuclear translocation of MiT/TFE family members MITF, TFE3, and TFEB, three master regulators of lysosomal biogenesis and autophagy. We demonstrate that the DENN domain of C9orf72 specifically binds to inactive Rag GTPases, but not active Rag GTPases, thereby affecting the function of Rag/raptor/mTOR complex and mTORC1 activity. Furthermore, active Rag GTPases, but not inactive Rag GTPases or raptor rescued the impaired activity and lysosomal localization of mTORC1 in C9orf72‐deficient cells. Taken together, the present study highlights a key role of C9orf72 in lysosomal and autophagosomal regulation, and demonstrates that Rag GTPases and mTORC1 are involved in C9orf72‐mediated autophagy.