bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninfectious neurologic complications of hematopoietic cell transplantation
Authors: Sheikh Mohammad Abdurrehman , Toledano Michel , Ahmed Sairah , Gul Zartash , Hashmi Shahrukh K. 
Published: May 2020

Objective/Background:
Neurological complications occur at a high frequency after hematopoietic cell transplantation (HCT). However, an absence is noted in the published literature as regards the quantification of the exact burden and the outcomes thereof. In this systematic review, we endeavored to detail if the recipients of HCT developed any noninfectious neurological events/complications.

Methods:
According to the PICO criteria, medical literature was searched. Complications that were evaluated included: stroke, peripheral neuropathy, myasthenia gravis, seizures, and posterior reversible encephalopathy syndrome. After strictly defining relevant variables and parameters, data from 173 eligible articles were then extracted accordingly, from the full text for each, for quantitative analysis; additionally, two American Society of Hematology conference abstracts were also subject to data extraction.

Results:
As is evident from the results of the data analysis, an increased frequency of these complications was seen in the HCT recipient population in comparison to the general population. The relative risk ranged from 1.33× to 142× depending on the complication studied.

Conclusion:
These findings demonstrate that the recipients of HCT had a significantly higher risk of neurological complications and that their early recognition can enhance the monitoring of HCT survivors for the early developmental signs of neurological toxicity. This would facilitate timely interventions, thus ensuring a better quality of life.
Covid-19, child and adolescent mental health – Croatian (in)experience
Authors: Franic Tomislav , Dodig-Curkovic Katarina 
Published: May 2020

AbstractThe Covid-19 pandemic has caused unseen socio-economic changes all over the world, where enormous efforts are being made to preserve lives and maintain functional health systems. A secondary concern is to mitigate the severe economic consequences of the crisis. Different approaches have been adopted with varying outcomes and experiences. But regardless of the different approaches taken, one thing is common for all societies during this pandemic: fear and anxiety. This fear extends from concerns about the present situation, for the health and well-being of family members and loved ones from Covid-19 infection, to fears relating to how long the crisis will last, to the potential economic consequences of the pandemic (perhaps not seen in our lifetimes) and the ultimate fear of future uncertainty. Across the world, health systems are being faced with unprecedented challenges. At their core, these challenges are the same: how to beat Covid-19. Certainly, there are differences in how individual systems are organized and how they address the main issues arising from the pandemic while not forgetting the ongoing healthcare needs of the general population. In this paper, we share some perspectives from Croatia regarding Child and Adolescent Mental Health services (CAMHs) in these extraordinary circumstances. We give our personal insights on deficiencies in Child and Adolescent Mental Health Services prior to the arrival of Covid-19, which have contributed to difficulties in mitigating and managing the ongoing crisis.
Forensic psychiatry and Covid-19: accelerating transformation in forensic psychiatry
Authors: Kennedy H. G. , Mohan D. , Davoren M. 
Published: May 2020

AbstractSwift medically led scientifically informed responses to the Covid-19 epidemic nationally have been demonstrably superior to other, non-scientific approaches. In forensic psychiatry and across all psychiatric services, urgent and clinically led responses have underlined redundancies and confusions in the governance of mental health services and a vacuum in policy makers. For the future, a greater emphasis on services for patients with schizophrenia and other severe, enduring mental disorders must aim at reducing standardised mortality ratios, managing risk of violence and improving hard outcomes such as symptomatic remission, functional recovery and forensic recovery of autonomy. This will require more use of information technology at service level and at national level where Scandinavian-style population-based data linkage research must now become legally sanctioned and necessary. A national research and development centre for medical excellence in forensic psychiatry is urgently required and is complimentary to and different from quality management.
The Role and Regulation of Child Factory Labour During the Industrial Revolution in Australia, 1873–1885
Authors: Johnston Madeleine 
Published: May 2020

AbstractThis study investigates child factory labour in Victoria, the most populous and industrialized colony in Australia in the second half of the nineteenth century. Three sources of primary data are analysed: Royal Commission reports, texts of bills and statutes, and parliamentary and public debates. The findings inform current academic debates by enhancing understanding of the role played by child workers during industrialization. They show that children were low-cost substitutes for adult males and that child labour was central to ongoing industrialization. A wide range of industries and jobs is identified in which children were employed in harsh conditions, in some instances in greater proportions than adults. Following the reports of the Royal Commission, the parliament of Victoria recognized a child labour problem serious enough to warrant regulation. While noting that circumstances were not as severe as in Britain, it passed legislation in 1885 with provisions that offered more protection to children than those in the British factory act of 1878. The legislation also offered more protection than factory laws in other industrializing colonies and countries. The findings throw light on the character of colonial liberal reformers in a wealthy colony who sought to create a better life for white settlers by adopting policies of state intervention.
Power in relations of international organisations: The productive effects of ‘good’ governance norms in global health
Authors: Pantzerhielm Laura , Holzscheiter Anna , Bahr Thurid 
Published: May 2020

AbstractIn recent years, scholarship on international organisations (IO) has devoted increasing attention to the relations in which IOs are embedded. In this article, we argue that the rationalist-institutionalist core of this scholarship has been marked by agentic, repressive understandings of power and we propose an alternative approach to power as productive in and of relations among IOs. To study productive power in IO relations, we develop a theoretical framework centred on the concept of ‘metagovernance norms’ as perceptions about the proper ‘governance of governance’ that are shared among IOs in a governance field. Drawing on discourse theory, we contend that metagovernance norms unfold productive power effects, as dominant notions of how to govern well and effectively (i) fix meanings, excluding alternative understandings and (ii) are inscribed into practices and institutions, hence reshaping inter-organisational relations over time. To illustrate our framework, we trace metagovernance norms in discourses among health IOs since the 1990s. We find a historical transformation from beliefs in the virtues of partnerships, pluralisation, and innovation, towards discursive articulations that emphasise harmonisation, order, and alignment. Moreover, we expose the productive power of metagovernance norms by showing how they were enacted through practices and institutions in the global health field.
The Expiration of Commitments in Adelaide Procter's “Homeward Bound”
Authors: Harrington Emily 
Published: May 2020

It has been a long time since the poetry of Adelaide Anne Procter, a favorite of Queen Victoria, captured much interest from readers of poetry, whether they be anthology aficionados, scholars, or students. Now considered a minor poet of the period, she was nevertheless a quintessential poet activist of her day, raising money for and working with the Providence Row Night Refuge, editing and contributing to the English Women's Journal alongside the Langham Place Feminists and the Society for the Employment of Women. She published volumes of her own poems, one of which ran to as many as nineteen editions between 1858 and 1881, and her work was featured regularly in Charles Dickens's periodical Household Words. Her legacy stands as a powerful testimony to the way ideas and tastes change over time. Full of angels, Christmases, quietly suffering children, and pious nuns (she converted to Catholicism in 1851), her poetry is often dismissed as sentimental and clichéd. A glance at her forms reveals many straightforward tetrameters with expected alternating, end-stopped rhymes, an easiness that seems to ally form and content. If Adorno had ever taken the time to read her poetry, he probably would have hated it, not just for its Catholic faith and its frequent focus on sin and redemption, but for its attempt “to work at the level of fundamental attitudes,” typical of committed art. Consider these lines from her frequently anthologized “Homeless,” which asks readers to recognize that their society takes better care of animals, criminals, and commodities than of the homeless poor:
For each man knows the market valueOf silk or woolen or cotton…But in counting the riches of EnglandI think our Poor are forgotten.
Goal-setting program improves nutrition and physical activity among Supplemental Nutrition Assistance Program eligible adults
Authors: Karamanian V , Zepka B , Ernst A , West C , Grode G , Miller C 
Published: May 2020

AbstractObjective:To examine the impact of Nutrition for Life (NFL), a goal-setting nutrition education program, on the knowledge, self-efficacy and behaviour of adults eligible for Supplemental Nutrition Assistance Program-Education.Design:NFL was developed using a 4-week goal-setting behavioural strategy focused on nutrition, physical activity and meal planning techniques. A quantitative repeated-measures design using self-reported data was collected at pre- and post-interventions and at 1-week and 1-month follow-ups.Setting:Two Federally Qualified Health Centers in Philadelphia, PA, USA.Participants:A total of ninety-eight participants enrolled in the intervention; the majority were women (80·2 %), Black/Non-Hispanic (75·0 %) and 45–54 year old (39·6 %).Results:Participants showed significant improvement in knowledge, self-efficacy and behaviour. Specifically, mean daily intake for vegetables increased by 0·31 cup (P < 0·05) and for fruits by 0·39 cup (P < 0·01) at 1-week follow-up. Participants also showed healthier behaviour at 1-month follow-up. Planning at least seven meals per week increased from 14·8 to 50 % (P < 0·01), completing at least 30 min of physical activity every day in the last week increased from 16·7 to 36 % (P < 0·01) and consuming water with all meals increased from 39 to 70·6 % (P < 0·01).Conclusions:The implementation of a goal-oriented nutrition education program offers a promising approach at achieving positive behaviour change among SNAP-eligible adults.
Embracing Uncertainty: Modeling the Standard Uncertainty in Electron Probe Microanalysis—Part I
Authors: Ritchie Nicholas W. M. 
Published: May 2020

AbstractThis is the first in a series of articles which present a new framework for computing the standard uncertainty in electron excited X-ray microanalysis measurements. This article will discuss the framework and apply it to a handful of simple, but useful, subcomponents of the larger problem. Subsequent articles will handle more complex aspects of the measurement model. The result will be a framework in which sophisticated and practical models of the uncertainty for real-world measurements. It will include many long overlooked contributions like surface roughness and coating thickness. The result provides more than just error bars for our measurements. It also provides a framework for measurement optimization and, ultimately, the development of an expert system to guide both the novice and expert to design more effective measurement protocols.
Longevity trend risk over limited time horizons
Authors: Richards Stephen J. , Currie Iain D. , Kleinow Torsten , Ritchie Gavin P. 
Published: May 2020

AbstractWe consider various aspects of longevity trend risk viewed through the prism of a finite time window. We show the broad equivalence of value-at-risk (VaR) capital requirements at a p-value of 99.5% to conditional tail expectations (CTEs) at 99%. We also show how deferred annuities have higher risk, which can require double the solvency capital of equivalently aged immediate anuities. However, results vary considerably with the choice of model and so longevity trend-risk capital can only be determined through consideration of multiple models to inform actuarial judgement. This model risk is even starker when trying to value longevity derivatives. We briefly discuss the importance of using smoothed models and describe two methods to considerably shorten VaR and CTE run times.
Settling of Immiscible Droplets: A Theoretical Model for the Missing Link Between Microscopic and Outcrop Observations
Authors: Zhang Zhongtian , Wu Benjun , Wang Tao , Hui Hejiu 
Published: May 2020

AbstractLiquid immiscibility is a critical mechanism to diversify magma compositions. The physical separation of exsolved melt droplets is an essential process in generating new magmas. However, little attention has been paid to this physical process. In this study, we present a new model for segregation of immiscible melt droplets in which exsolution, settling, and coalescence are all considered. The separation of immiscible droplets is similar to that of crystals in magma when the discrete melt exsolves as large (millimeter‐size) droplets and/or when the magma cools slowly. However, when immiscible melt droplets are small (micrometer‐size) and/or magma cools rapidly, coalescence can significantly enhance their separation. The low interfacial tension between coexisting silicate melts leads to the exsolution of extremely small melt droplets. Furthermore, the high viscosity of silica‐rich melt suppresses the coalescence of droplets. Consequently, the separation of highly viscous silica‐rich melt droplets is slow but could have occurred in a slowly cooling magma such as the Skaergaard intrusion. By contrast, the coalescence rate of melt droplets with low viscosity is high. Iron‐rich melt droplets, which have low viscosities, could have been separated from hydrous andesitic melts to form magnetite‐apatite ore deposits at El Laco and Marcona. Furthermore, the viscosities of sulfide and carbonatitic melts are low. Therefore, immiscibility between sulfide and silicate melts may lead to the formation of magmatic sulfide deposits, and immiscibility between carbonatitic and silicate melts can support periodical eruptions of carbonatitic lava.
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Authors: Hwang Jeong-Ryul , Byeon Yeongseon , Kim Donghwan , Park Sung-Gyoo 
Published: May 2020

AbstractT cell activation requires extracellular stimulatory signals that are mainly mediated by T cell receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility complex molecules with the cooperation of CD4 or CD8 coreceptors. After recognition, TCR-induced signaling cascades that propagate signals via various molecules and second messengers are induced. Consequently, many features of T cell-mediated immune responses are determined by these intracellular signaling cascades. Furthermore, differences in the magnitude of TCR signaling direct T cells toward distinct effector linages. Therefore, stringent regulation of T cell activation is crucial for T cell homeostasis and proper immune responses. Dysregulation of TCR signaling can result in anergy or autoimmunity. In this review, we summarize current knowledge on the pathways that govern how the TCR complex transmits signals into cells and the roles of effector molecules that are involved in these pathways.
LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma
Authors: Liu Boyang , Zhou Jian , Wang Chenyang , Chi Yajie , Wei Quantang , Fu Zhao , Lian Changlin , Huang Qiongzhen , Liao Chenxin , Yang Zhao , Zeng Huijun , Xu Ningbo , Guo Hongbo 
Published: May 2020

AbstractTemozolomide (TMZ) resistance is a major cause of recurrence and poor prognosis in glioblastoma (GBM). Recently, increasing evidences suggested that long noncoding RNAs (LncRNAs) modulate GBM biological processes, especially in resistance to chemotherapy, but their role in TMZ chemoresistance has not been fully illuminated. Here, we found that LncRNA SOX2OT was increased in TMZ-resistant cells and recurrent GBM patient samples, and abnormal expression was correlated with high risk of relapse and poor prognosis. Knockdown of SOX2OT suppressed cell proliferation, facilitated cell apoptosis, and enhanced TMZ sensitivity. In addition, we identified that SOX2OT regulated TMZ sensitivity by increasing SOX2 expression and further activating the Wnt5a/β-catenin signaling pathway in vitro and in vivo. Mechanistically, further investigation revealed that SOX2OT recruited ALKBH5, which binds with SOX2, demethylating the SOX2 transcript, leading to enhanced SOX2 expression. Together, these results demonstrated that LncRNA SOX2OT inhibited cell apoptosis, promoted cell proliferation, and TMZ resistance by upregulating SOX2 expression, which activated the Wnt5a/β-catenin signaling pathway. Our findings indicate that LncRNA SOX2OT may serve as a novel biomarker for GBM prognosis and act as a therapeutic target for TMZ treatment.
Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy
Authors: Zhao Zhe , Xiang Shufen , Qi Jindan , Wei Yijun , Zhang Mengli , Yao Jun , Zhang Tong , Meng Mei , Wang Xiaohua , Zhou Quansheng 
Published: May 2020

AbstractSalvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types. SAV1 deficiency in cells promotes tumorigenesis and cancer metastasis, and is closely associated with poor prognosis for cancer patients. However, investigation of therapeutic strategies to target SAV1 deficiency in cancer is lacking. Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin–lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1). MST1 activation then caused phosphorylation, ubiquitination, and degradation of the oncogenic Yes-associated protein (YAP), therefore inhibiting YAP-activated transcription of oncogenic genes and tumorigenic AKT and NF-κB signal pathways. Strikingly, treating tumor-bearing xenograft mice with lycorine increased SAV1 levels, and strongly inhibited tumor growth, vasculogenic mimicry, and metastasis. This work indicates that correcting SAV1 deficiency in lung cancer cells is a new strategy for cancer therapy. Our findings provide a new platform for developing novel cancer therapeutics.
Nondestructive ultrafast steering of a magnetic vortex by terahertz pulses
Authors: Yu Dongxing , Kang Jiyong , Berakdar Jamal , Jia Chenglong 
Published: May 2020

AbstractElectric control of magnetic vortex dynamics in a reproducible way on an ultrafast time scale is a key element in the quest for efficient spintronic devices with low-energy consumption. To be useful, the control scheme should ideally be swift, be scalable, be noninvasive, and result in reliable magnetic switching. Such requirements, particularly the reproducibility of altering the vortex chirality and/or polarity, are not yet met by magnetic vortex switching via external magnetic fields, spin-polarized currents, spin waves, or laser pulses. Here, we demonstrate a novel packaged-skyrmion-mediated vortex switching process driven by a simple sequence of picosecond electrical field pulses via magnetoelectric interactions. Both the vortex chirality and polarity show a well-defined reversal behavior. The unambiguous repeated switching between four different magnetic vortex states provides an energy-efficient, highly localized, and coherent control method for nonvolatile magnetic vortex-based information storage and handling.
Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
Authors: Yin Qinglei , Ni Qicheng , Wang Yichen , Zhang Hongli , Li Wenyi , Nie Aifang , Wang Shu , Gu Yanyun , Wang Qidi , Ning Guang 
Published: May 2020

AbstractCompromised β-cell identity is emerging as an important contributor to β-cell failure in diabetes; however, the precise mechanism independent of hyperglycemia is under investigation. We have previously reported that mTORC1/Raptor regulates functional maturation in β-cells. In the present study, we find that diabetic β-cell specific Raptor-deficient mice (βRapKOGFP) show reduced β-cell mass, loss of β-cell identity and acquisition of α-cell features; which are not reversible upon glucose normalization. Deletion of Raptor directly impairs β-cell identity, mitochondrial metabolic coupling and protein synthetic activity, leading to β-cell failure. Moreover, loss of Raptor activates α-cell transcription factor MafB (via modulating C/EBPβ isoform ratio) and several α-cell enriched genes i.e. Etv1 and Tspan12, thus initiates β- to α-cell reprograming. The present findings highlight mTORC1 as a metabolic rheostat for stabilizing β-cell identity and repressing α-cell program at normoglycemic level, which might present therapeutic opportunities for treatment of diabetes.
Gravitational-wave asteroseismology with fundamental modes from compact binary inspirals
Authors: Pratten Geraint , Schmidt Patricia , Hinderer Tanja 
Published: May 2020

AbstractGravitational waves (GWs) from binary neutron stars encode unique information about ultra-dense matter through characterisic signatures associated with a variety of phenomena including tidal effects during the inspiral. The main tidal signature depends predominantly on the equation of state (EoS)-related tidal deformability parameter Λ, but at late times is also characterised by the frequency of the star’s fundamental oscillation mode (f-mode). In General Relativity and for nuclear matter, Λ and the f-modes are related by universal relations which may not hold for alternative theories of gravity or exotic matter. Independently measuring Λ and the f-mode frequency enables tests of gravity and the nature of compact binaries. Here we present directly measured constraints on the f-mode frequencies of the companions of GW170817. We also show that future GW detector networks will measure f-mode frequencies to within tens of Hz, enabling precision GW asteroseismology with binary inspiral signals alone.