bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical profiling of selected Ayurveda formulations recommended for Covid-19&nbsp;&nbsp;
Authors: T Sulaiman C , M Deepak , R Ramesh P , K Mahesh , M Anandan E , Balachandran Indira 
Published: September 2020

Abstract
Background: The novel coronavirus disease 2019 (COVID-19), caused by the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is the global health concern since December 2019. It has become a big challenge for the researchers to find a solution for this newly evolved pandemic. In Ayurveda point of view, COVID-19 is a Janapadodhwamsa vikara (epidemic disease), a situation where the environment - air, water, land and seasons - is vitiated, causing a simultaneous manifestation of a disease among large populations. The aim of this study is to identify the active compounds of selected Ayurveda medicines recommended for covid-19.Methods: Chemical profiling of selected Ayurveda medicines such as Indukantham Kwatham (IK), Vilvadi Gulika (VG) and Mukkamukkatuvadi Gulika (MMG) were carried out by High Performance Thin Layer Chromatographic (HPTLC) analysis.Results: The selected preparations are traditionally recommended for the management of various kinds of fever including the infectious ones and to enhance the immunity. HPTLC analysis of the same showed presence of many active molecules like Umbelliferone, Scopoletin, Caffeic acid, Ferulic acid, Gallic acid, Piperin, Curcumin, Berberine and Palmatine.Conclusion: The study provided valuable scientific data regarding the active ingredients of the selected medicines with proven therapeutic potentials like anti-viral, immunomodulatory and anti-inflammatory activities and it will be beneficial to acquire immunity against Coronavirus-2 attack.
Ciclos de discussão de segurança alimentar e nutricional: promovendo a troca de saberes entre sala de aula e a comunidade
Authors: LOPES Sílvia Oliveira , MORAIS Dayane de Castro , MIGUEL Elizangela da Silva , TRIVELLATO Paula Torres , DUTRA Luiza Veloso , PINTO Carina Aparecida , PRIORE Silvia Eloiza 
Published: September 2020

O objetivo do trabalho é analisar os resultados e reflexões geradas nos encontros do “Ciclo de Discussão de Segurança Alimentar e Nutricional”. Nestes Ciclos são compartilhadas as construções da disciplina “Determinantes da Insegurança Alimentar e Nutricional” difundindo e valorizando trabalhados dos pós-graduandos e docentes em temas relacionados à Segurança Alimentar e Nutricional (SAN). A análise dos temas discutidos nos Ciclos, por meio da análise de conteúdo e de similitude, considerou-se as oito diretrizes da Política Nacional de Segurança Alimentar e Nutricional (PNSAN). Foram realizados oito Ciclos, sendo estes anuais. Todas as discussões basearam-se em diferentes temáticas que permearam o contexto da SAN e contemplaram pelo menos um dos eixos das diretrizes da PNSAN. Conclui-se que ações como estas são importantes para estimular o pensamento crítico para além da sala de aula e propiciar a troca de saberes entre universidade e comunidade, consolidando a tríade ensino, pesquisa e extensão.
Immuno-Informatics Quest against COVID-19/SARS-COV-2: Determining Putative T-Cell Epitopes for Vaccine Prediction
Authors: Akhtar Nahid , Joshi Amit , Singh Bhupender , Kaushik Vikas 
Published: September 2020

Background:
Since December 2019, a novel coronavirus, SARS-CoV-2, has caused
global public health issues after being reported for the first time in Wuhan province of China. So
far, there have been approximately 14.8 million confirmed cases and 0.614 million deaths due to
the SARS-CoV-2 infection globally, and still, numbers are increasing. Although the virus has
caused a global public health concern, no effective treatment has been developed.

Objective:
One of the strategies to combat the COVID-19 disease caused by SARS-CoV-2 is the
development of vaccines that can make humans immune to these infections. Considering this approach,
in this study, an attempt has been made to design epitope-based vaccine for combatting
COVID-19 disease by analyzing the complete proteome of the virus by using immuno-informatics
tools.

Methods:
The protein sequence of the SARS-CoV-2 was retrieved and the individual proteins were
checked for their allergic potential. Then, from non-allergen proteins, antigenic epitopes were identified
that could bind with MHCII molecules. The epitopes were modeled and docked to predict the
interaction with MHCII molecules. The stability of the epitope-MHCII complex was further analyzed
by performing a molecular dynamics simulation study. The selected vaccine candidates were
also analyzed for their global population coverage and conservancy among SARS-related coronavirus
species.

Results:
The study has predicted 5 peptide molecules that can act as potential candidates for epitope-
based vaccine development. Among the 5 selected epitopes, the peptide LRARSVSPK can be
the most potent epitope because of its high geometric shape complementarity score, low ACE and
very high response towards it by the world population (81.81% global population coverage). Further,
molecular dynamic simulation analysis indicated the formation of a stable epitope-MHCII
complex. The epitope LRARSVSPK was also found to be highly conserved among the SARS-CoV-
-2 isolated from different countries.

Conclusion:
The study has predicted T-cell epitopes that can elicit a robust immune response in
the global human population and act as potential vaccine candidates. However, the ability of these
epitopes to act as vaccine candidate needs to be validated in wet lab studies.
Short-Lasting Unilateral Neuralgiform Headache Attacks with Conjunctival Injection and Tearing (SUNCT) Status Like Condition: A Rare Case Report and Review of the Literature.
Authors: Gurumukhani Jayanti K , Patel Dhruvkumar M. , Patel Mukundkumar V. , Patel Maitri M. , Patel Anand V , Patel Suyog Y 
Published: September 2020

Background:
SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) is rare trigeminal autonomic cephalgia characterized by recurrent, brief, excruciating unilateral, intermittent headache paroxysms over orbital, frontal or temporal region occurring multiple times per day and it can rarely present as “SUNCTstatus like condition” (SSLC).

Case Report:
A 28-year old male with a history of SUNCT headache for 6 months presented with left forehead stabs lasting for 30 seconds with a frequency of 40-45 episodes per hour for three days followed by infective gastroenteritis. His neurological examination was normal, except left-sided ptosis, tearing, and conjunctival injection. His MRI brain with contrast, MR angiography, and laboratory investigations were unremarkable except mild hypokalemia. He was treated with intravenous fluids, potassium replacement, and high dose methylprednisolone along with an escalated dose of carbamazepine.

Review and Conclusion:
We have reviewed the previously reported seven cases and our case of SSLC. Female: Male ratio was 3:1and the mean age was 40.87 years. Three patients responded to high dose steroids and three to lignocaine along with rapid escalation or change of anticonvulsant drugs. One case responded to the high dose of lamotrigine, and in a pregnant lady, the pain subsided only after the termination of the pregnancy. One case was secondary to multiple sclerosis, while the rest of seven were primary episodic SSLC. The condition is highly disabling, and the treatment with steroids or lignocaine, along with the rapid escalation of preventive drugs, can provide long-lasting relief
Follow-Up of Cancer Patients Receiving Anti-PD-(L)1 Therapy Using an Electronic Patient-Reported Outcomes Tool (KISS): Prospective Feasibility Cohort Study
Authors: Iivanainen Sanna , Alanko Tuomo , Vihinen Pia , Konkola Teemu , Ekstrom Jussi , Virtanen Henri , Koivunen Jussi 
Published: September 2020

Background
Immune checkpoint inhibitors (ICIs) have become a standard of care for various tumor types. Their unique spectrum of side effects demands continuous and long-lasting assessment of symptoms. Electronic patient-reported outcome (ePRO) follow-up has been shown to improve survival and quality of life of cancer patients treated with chemotherapy.

Objective
This study aimed to investigate whether ePRO follow-up of cancer patients treated with ICIs is feasible. The study analyzed (1) the variety of patient reported symptoms, (2) etiology of alerts, (3) symptom correlations, and (4) patient compliance.

Methods
In this prospective, one-arm, multi-institutional study, we recruited adult cancer patients whose advanced cancer was treated with anti-programmed cell death protein 1 (PD)- ligand (L)1 agents in outpatient settings. The ePRO tool consisted of a weekly questionnaire evaluating the presence of typical side effects, with an algorithm assessing the severity of the symptom according to National Cancer Institute Common Terminology Criteria for Adverse Events and an urgency algorithm sending alerts to the care team. A patient experience survey was conducted monthly. The patients were followed up to 6 months or until disease progression.

Results
A total of 889 symptom questionnaires was completed by 37 patients (lung cancer, n=15; melanoma, n=9; genitourinary cancer, n=9; head and neck cancer, n=4). Patients showed good adherence to ePRO follow-up. The most common grade 1 symptoms were fatigue (28%) and itching (13%), grade 2 symptoms were loss of appetite (12%) and nausea (12%), and grade 3-4 symptoms were cough (6%) and loss of appetite (4%). The most common reasons for alerts were loss of appetite and shortness of breath. In the treatment benefit analysis, positive correlations were seen between clinical benefit and itching as well as progressive disease and chest pain.

Conclusions
According to the results, ePRO follow-up of cancer patients receiving ICIs is feasible. ePROs capture a wide range of symptoms. Some symptoms correlate to treatment benefit, suggesting that individual prediction models could be generated.

Trial Registration
Clinical Trials Register, NCT3928938; https://clinicaltrials.gov/ct2/show/NCT03928938
Controlling the Sense of Embodiment for Virtual Avatar Applications: Methods and Empirical Study
Authors: Kim Chang-Seop , Jung Myeongul , Kim So-Yeon , Kim Kwanguk 
Published: September 2020

BackgroundThe sense of embodiment (SoE) is the feeling of one’s own body, and research on the SoE extends from the rubber hand illusion to the full-body ownership illusion with a virtual avatar.ObjectiveThe key to utilizing a virtual avatar is understanding and controlling the SoE, and it can be extended to several medical applications. In this study, we aimed to clarify these aspects by considering the following three subcomponents of SoE: sense of agency, ownership, and self-location.MethodsWe defined a human avatar (HA), point light avatar (PLA), and out-of-body point light avatar (OBPLA) and compared them in three user studies. In study 1, 28 participants were recruited and the three avatar conditions (HA, PLA, and OBPLA) were compared. In study 2, 29 new participants were recruited, and there were two avatar conditions (HA ad PLA) and two motion synchrony conditions (synchrony and asynchrony). In study 3, 29 other participants were recruited, and there were two avatar conditions (PLA and OBPLA) and two motion synchrony conditions (synchrony and asynchrony). Dependent measures included sense of agency, ownership, and self-location; emotional response; presence; and simulator sickness.ResultsThe findings of study 1 showed that the three avatar generation methodologies can control the sense of ownership and self-location in a stepwise manner while maintaining a high sense of agency. In studies 2 and 3, we found dependencies among the three subcomponents of SoE and observed that they affected users’ subjective experiences.ConclusionsOur findings may have implications for boosting the effects of virtual avatar applications in medical areas, by understanding and controlling the SoE with a full-body illusion.
The Effect of "Quantum Learning" Model Using "Mind Mapping" Technique to Eight Grade Students’ Creative Thinking Ability
Authors: Eriyanto Erik , Inganah Siti , Utomo Dwi Priyo 
Published: September 2020

This study aims to determine how the effect of the Quantum Learning model using Mind Mapping techniques to students' creative thinking abilities. The type of research used is experiment and quantitative approach with research design using posttest only group design. Data analysis of two groups used the t-test on SPSS 21, that is Independent Sample t-Test to test the difference in average posttest value of two samples.The results of this study are (1) results of the t-test from post-test data obtain a significance 0,000 where it is lower than 0.05 so can be said that the average of the two groups are different, (2) from the post-test results, the answers given by students from the experimental group more fulfilled the indicators of creative thinking than students from the control group.
An Analysis of Students' Errors to Find the Result Reflection in Coordinate Plane Based On in the Newman Error Analysis Nints-Grade Students of Junior High School 2 Sampit
Authors: Sari Ayu Amelia , Utomo Dwi Priyo , Zukhrufururrohmah Zukhrufururrohmah 
Published: September 2020

This study aimed to determine the types and the causes of students' errors in finding the results of reflection in the field of coordinates based on the Newman problem-solving. This research used descriptive research with a quantitative approach. The data collection techniques were written test and a structured interview with the research subjects were Nints-grade students of Junior High School 2 Sampit. Based on the results of the data analysis, there were errors made by students, namely: (1) there were no mistakes in the problem of reading stage, (2) students were not able to write down the known and asked even though students understood the questions presented in the stage of understanding the problem, (3) did not change the questions into a coordinate field in the stage of transformation problem, (4) misplaced of the result reflection and miscalculating the result of reflection on the process skill stage, (5) did not writing down the answers or conclusions in the writing answers stage.
REGULARIZED POLITICAL APOLOGY
Authors: Milam Per-Erik , Don Allison 
Published: September 2020

Abstract
Our world has been shaped by the injustices of the past. Many of the nations responsible for these injustices still exist, and there are many cases in which one can point to culpable wrongdoing and identify victims and offenders. Such cases demand apologies as a matter of justice, respect, and due concern. In this paper, we argue that some states should institute a practice of regular political apology by (a) designating a regular day of apology on which the head of state publicly apologizes for a different past instance of serious misconduct by the state, and (b) supplementing these apologies with related actions or policies intended to make amends to the victims or their descendants.
Penerapan Model Pembelajaran Kooperatif Tipe STAD untuk Meningkatkan Hasil Belajar Bahasa Inggris
Authors: Sukarta I Made 
Published: September 2020

Tujuan dari penelitian ini adalah untuk meningkatan hasil belajar Bahasa Inggris siswa dengan menerapkan Model Pembelajaran Kooperatif Tipe STAD siswa kelas X. Penelitian ini termasuk jenis Penelitian Tindakan Kelas (PTK) dengan rancangan deskriptif analitis . Penelitian ini dilaksanakan di Kelas X AP 1 yang kemampuan siswanya dalam pemahaman materi mata pelajaran Bahasa Inggris cukup rendah. Model pengumpulan data yang digunakan adalah tes hasil belajar, dan Model analisis datanya adalah deskriptif untuk data kuantitatif. Prosedur penelitian yang digunakan yaitu penelitian tindakan kelas dengan menggunakan dua siklus dimana setiap siklus terdiri dari 4 tahapan yaitu; Perencanaan, Pelaksanaan, Pengamatan, Refleksi. Hasil yang diperoleh dari penelitian ini dapat dijabarkan sebagai berikut: untuk data awal rata-rata 59,50, data siklus I terjadi peningkatan yaitu 68,00, dan rata-rata pada siklus II meningkat menjadi 76,50. Ketuntasan belajar pada data awal 23,33 %, Ketuntasan belajar pada siklus I adalah 66,67%, dan ketuntasan belajar pada silus II mencapai 100%. Jadi, pelaksanaan pembelajaran bahasa inggris dengan menerapkan Model Pembelajaran Kooperatif Learning tipe STAD pada siswa kelas X AP 1 Semester 2, dapat meningkatkan hasil belajar bahasa inggris secara
Meningkatkan Hasil Belajar IPA Melalui Penerapan Metode Inkuiri Terbimbing
Authors: Sujana I Gede 
Published: September 2020

Penelitian tindakan kelas ini bertujuan untuk mengetahui pengaruh penerapan metode pembelajaran inquri terbimbing terhadap hasil belajar siswa kelas VI pada mata pelajaran ilmu pengetahuan alam (IPA). Penelitian tindakan kelas ini dilaksanakan di SD. Subjek penelitian tindakan kelas ini adalah siswa kelas VI SD dengan populasi 19 orang siswa, terdiri dari 7 orang siswa laki-laki dan 12 orang siswa perempuan. Pengambilan data dalam penelitian ini dilakukan dengan pemberian tes kepada siswa. Metode ini digunakan untuk mengevaluasi hasil belajar siswa. Analisis data menggunakan dua metode, yaitu analisis data statistik deskriptif dan deskriptif kuantitatif. Hasil penelitian menunjukkan hasil belajar siswa kelas VI pada mata pelajaran IPA, dengan metode inquiri terbimbing dapat ditingkatkan. Hal ini dapat dilihat berdasarkan hasil penelitian yang diperoleh dimana awalnya persentase ketuntasan siswa mencapai 68,16% dimana nilai ini masuk dalam kategori sedang. Pada siklus I ketuntasan siswa naik menjadi 74,74% masuk dalam kategori tinggi, dan pada siklus II ketuntasan siswa terus meningkat menjadi 86,32% dimana persentase ini masuk kategori sangat tinggi. Hasil penelitian tersebut menunjukkan bahwa penggunaan metode inquiri terbimbing pada siswa kelas VI SD pada materi IPA di semester ganjil dapat meningkatkan hasil belajar siswa.
Pelatihan Career Planning Untuk Meningkatkan Kemampuan Mahasiswa dalam Merumuskan Rencana Karier
Authors: Saputra Muhammad Ridwan 
Published: September 2020

Abstrak: Pelatihan career planning untuk meningkatkan kemampuan mahasiswa dalam merumuskan rencana karier. Banyak mahasiswa kesulitan dalam menetapkan target karier dikarenakan minimnya informasi yang diperoleh, mereka tidak memiliki gambaran mengenai pekerjaan yang sesuai dengan bidang keilmuannya di perguruan tinggi. Selain itu, banyak dari mereka yang cenderung kurang memiliki kepedulian mengenai rencana karier di kemudian hari. Oleh sebab itu, penting untuk memberikan bantuan kepada mahasiswa agar mampu merumuskan rencana karier terutama saat sedang berproses di perguruan tinggi. Salah satu upaya yang dapat dilakukan ialah dengan mengadakan pelatihan career planning. Pelatihan ini dilakukan bertujuan untuk meningkatkan pemahaman dan keterampilan mahasiswa dalam merumuskan rencana karier. Pihak yang terlibat pada penelitian ini sebanyak 19 orang mahasiswa Strata 1 Fakultas Psikologi Universitas Ahmad Dahlan Yogyakarta. Desain penelitian yang digunakan ialah One Group Pre-test Post-test Design dengan analisis data Wilcoxon Signed Rank Test dan analisis deskriptif. Hasil analisis yang diperoleh menunjukkan negative ranks = 0 dan positive ranks = 19 (mean rank = 10.00) serta nilai signifikansi sebesar 0.000 (<0.05). Hal ini menjelaskan bahwa pelatihan career planning mampu meningkatkan kemampuan dan keterampilan mahasiswa dalam merumuskan rencana karier, mereka mampu menetapkan target karier yang diinginkan serta merencanakan upaya pengembangan diri yang diperlukan sesuai dengan minat dan kebutuhan.Kata kunci : Perencanaan karier, pelatihan, mahasiswa
Pengaruh Dukungan Sosial Terhadap Kualitas Hidup ODHA di Kota Makassar KDS Saribattangku
Authors: Aswar Aswar , Munaing Munaing , Justika Justika 
Published: September 2020

The effect of Social Support on the Quality of Life of ODHA in Saribattangku KDS Makassar.This study aims to determine the effect of social support on the quality of life of PLWHA in KDS Saribattangku Makassar City. This research uses quantitative methods. The subjects in this study were 37 people using simple random sampling. Data analysis techniques used normality and linearity tests, and simple regression tests using SPSS 20 for Windows. The results of this study were analyzed by simple linear regression showing the value of F = 14.019 with a significance of 0.003 (p <0.05) which proves that social support has a significant effect on the quality of life of PLWHA in Makassar City, Saribattangku KDS. While the R2 value of 0.221 indicates that social support affects the quality of life of PLWHA by 22.1%. Based on these results, the hypothetical research is accepted.
GORGA SINGA-SINGA SEBAGAI SUMBER IDE PENCIPTAAN KARYA SENI LUKIS
Authors: Mangatas Pasaribu Renjaya Siahaan Dan 
Published: September 2020

ABSTRAK Penelitian ini bertujuan untuk mengekspresikan motif gorga singa-singa ke dalam sebuah lukisan, mengungkapkan teknik dalam karya lukis, mengungkapkan bagaimana pengayaan yang menjadi ciri khas pelukis dalam berkarya pada seni lukis dan menjelaskan bagaimana perubahan bentuk gorga singa-singa pada lukisan.Dalam pemilihan material dan alat perlu diperhitungkan oleh perupa sebagai pendukung dalam proses pembuatan karya. Dengan perkembangan jaman yang semakin meningkat, para seniman pun mencari dan melakukan percobaan terhadap alat dan bahan untuk mendapatkan kecocokan efek-efek visual maupun hal-hal baru yang diyakini bisa sebagai media untuk meluangkan ide-ide yang telah didapatkan. Seniman biasanya bebas menggunakan teknik yang diikutinya dari seniman-seniman yang terdahulu, maupun teknik-teknik yang dikembangkan dari teknik sebelumnya oleh perupa itu sendiri dalam melukiskan ide-idenya.Pada penelitian ini diperoleh kesimpulan bahwa Pemaknaan filosofi gorga singa-singa yang yang diterapkan pada karya lukis berdasarkan pemaknaan yang terdapat pada masyarakat Batak Toba yang dilukiskan dengan kombinasi bentuk-bentuk binatang, manusia, pola sulur-suluran, tali-temali, akar pohon, stalagntit-stalagtit pada gua. Penambahan ataupun pengurangan yang dilakukan penulis dalam karya lukis menimbulkan efek berbeda dari gorga singa-singa dengan tujuan pengayaan dan pengembangan gorga singa-singa ke dalam bentuk karya lukis yang menurut penulis dapat menambah nilai keindahan pada hasil karya lukis. Warna yang digunakan penulis dalam hasil karya lukis yaitu warna kuning, orange, coklat, biru, merah maron yang menghasilkan monokrom orange, warna hitam merah dan putih mewakili warna yang ada pada gorga singa-singa. Teknik yang digunakan dalam pembuatan karya lukis ini menggunakan beberapa campuran teknik dalam melukis yang tujuannya untuk memperoleh efek-efek yang dapat mendukung bentuk visualisaisi dalam lukisan Kata kunci : Gorga Singa-Singa, Seni Lukis