bluuebunny/crossref_metadata_2025_split huggingface dataset:
405Acute and short-term effects of diesel exhaust fumes exposure on arterial wall properties, inflammatory process and fibrosis-fibrinolysis status
Authors: Fountoulakis P , Oikonomou E , Papaioannou T , Psaltopoulou T , Tsalamandris S , Papamikroulis G A , Kalampogias A , Pallantza Z , Pavlou E , Milliou A , Asimakopoulou M N , Barbaresos N , Giannarakis I , Siamata P , Tousoulis D 
Published: October 2019

Abstract

Introduction
Exhaust fumes from diesel engines are a complex mixture of toxic compounds with a wide variety of harmful effects. The acute effects of diesel exhaust fumes on the cardiovascular system are well-known. However, their short-term impact has not been thoroughly studied.

Purpose
To study the acute and short-term (24 h) effects of diesel exhaust particles (DEPs) on endothelial function, arterial wall properties, inflammatory process and fibrosis-fibrinolysis status.

Methods
In this blind cross over study, 40 healthy volunteers (median age 40 years old) have been exposed to diesel exhaust particles (DEPs) and then to filtered air (FA) over a 2-hour session with a wash out period of 4 weeks. Exposure to DEPs was calibrated based on the mass of microparticles less than 2,5 microns in diameter (PM 2,5). Flow-mediated-dilation (FMD) was used to estimate endothelial function. Pulse wave velocity (PWV) and augmentation index (AIx) assessed central aortic stiffness and arterial reflected waves respectively. C reactive protein (CRP) was measured to determine the inflammatory status, as well as fibrinogen and protein C levels to evaluate the impact on the coagulation cascade. All measurements were performed before each session (T0), at the end of the 2 hours exposure session (T2) and 24 hours after completion of each session (T24). Variables with normal distribution are presented as mean±SD otherwise as median±SEM.

Results
At T0 of DEP and FA exposure there was no significant difference in FMD, PWV, AIX, CRP, protein C and fibrinogen levels. Exposure to DEP decreased significantly FMD (T0: 11.97±4.61% vs T2: 7.71±3.36% vs. T24: 6.17±3.19%, p<0.001) and increased PWV (T0: 6.09±1.03m/sec vs T2: 7.22±1.31m/sec vs. T24: 6.90±1.03m/sec, p<0.001), AIx (T0: 8.17±3.19% vs T2: 12.71±3.36% vs. T24: 13.17±4.61%, p<0.001), CRP (T0: 1.41±0.18 mg/L vs T2: 1.99±0.21mg/L vs. T24: 2.08±0.24mg/L, p=0.04) and fibrinogen levels (T0: 269±44 mg/dL vs T2: 331±75 mg/dL vs. T24: 307±51 mg/dL, p=0.002). Protein C was significantly reduced (T0: 121±26% vs T2: 104±21% vs. T24: 105±20%, p=0.003). Exposure to FA had no significant impact on the study parameters.
Graph of results

Conclusion
Exposure to diesel exhaust fumes may have significant adverse effects on the cardiovascular system with impairment of endothelial function, arterial wall properties, inflammatory status and fibrosis-fibrinolysis parameters not only during the exposure period but as far as 24 hours after exposure.

Acknowledgement/Funding
None
P321A single factor related to left atrial pressure overload is useful for prognosis in elderly patients with heart failure with preserved ejection fraction: PURSUIT HFpEF study
Authors: Hoshida S , Watanabe T , Shinoda Y , Minamisaka T , Fukuoka H , Inui H , Ueno K , Yasumura Y , Yamada T , Uematsu M , Tamaki S , Higuchi Y , Abe H , Hikoso S , Sakata Y 
Published: October 2019

Abstract

Background
E/e' and the ratio of diastolic elastance (Ed)/arterial elastance (Ea) = (E/e')/(0.9 × systolic blood pressure), indices of left atrial (LA) pressure overload, are elevated in elderly women with heart failure with preserved ejection fraction (HFpEF). The severity of diastolic dysfunction is assessed by a combination of several indices of LA volume and pressure overload. However, which overload is more important as a single factor for the prognosis of these patients remains undefined.

Methods
We enrolled patients with HFpEF showing sinus rhythm (n=145; left ventricular ejection fraction >50%; men/women, 56/89; mean age, 80.5 years). Blood examination and transthoracic echocardiography were performed before discharge. All-cause mortality and admission for cardiac events were evaluated after more than 1 year (mean, 370 days).

Results
The all-cause mortality rate was 11% (16/145). There were significant differences in age (p=0.005), serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level (p<0.001), LA volume index (p=0.018), E/e' (p=0.022), and Ed/Ea (p=0.016) between patients with and without all-cause mortality. When cutoff points for mortality by receiver operating characteristic curve analysis were examined, the area under the curve in LA volume index (0.564) was slightly smaller than that in age (0.734), NT-proBNP level (0.732), E/e' (0.695), and Ed/Ea (0.709). Kaplan-Meier survival analysis clearly showed that age >85 years (p<0.001), NT-proBNP level >888 pg/mL (p=0.003), E/e' >14.4 (p=0.020), and Ed/Ea >0.153 (p<0.001) were determinant factors for mortality. Cox hazard ratios were also significant in these indices (p=0.002, p=0.012, p=0.028, and p=0.001, respectively). In the case of all-cause mortality or admission for cardiac events, the results were nearly similar as those in the case of all-cause mortality. Ed/Ea exhibited a larger Cox hazard ratio for prognosis than E/e' in the multivariate analysis.

Conclusions
LA pressure overload compared to volume overload was a useful marker for prognosis in elderly patients with HFpEF. As a single index for LA pressure overload in noninvasive echocardiographic findings, Ed/Ea may be more suitable than E/e'.
P342Time-to-isolation-guided cryoballoon pulmonary vein isolation reduces esophageal and mediastinal alterations detected by endoscopic ultrasound
Authors: Ellermann C , Cordes F , Dechering D G , Frommeyer G , Kochhaeuser S , Lange P S , Pott C , Lenze F , Schmidt H , Ullerich H , Eckardt L 
Published: October 2019

Abstract

Background
Pulmonary vein isolation (PVI) is recommended for treatment of symptomatic atrial fibrillation. Cryoballoon ablation is an emerging safe and efficient technique for achieving PVI. Nevertheless, structural alterations of the mediastinum and/or the oesophagus, which seem to be associated with an increased risk of the lethal complication of an atrio-oesophageal fistula, have been described.

Purpose
MADE-PVI (Mediastino-oesophageal Alterations Detected by Endosonography after PVI) aimed at evaluating safety of cryoballoon PVI in relation to two different freeze protocols. As a time-to-isolation (TTI)-guided protocol has been reported to be as effective as a conventional “two freeze protocol”, we hypothesized that a TTI-guided protocol causes less peri-atrial and -oesophageal lesions.

Methods
70 consecutive patients were scheduled for de novo cryoballoon (2nd generation) PVI employing either a conventional freeze protocol (Group A: n=35: 2x180s per vein) or a TTI-guided approach (Group B: n=35; freeze time: TTI+120s per vein or 1x180s in case TTI could not be measured). Structural oesophageal and mediastinal alterations (e.g. ulceration, oedema) were assessed by endoscopy and endosonography blinded prior and post ablation.

Results
Irrespective of used freeze protocol, ablation significantly increased atrio-oesophageal distances, including distance to left and right inferior pulmonary vein ostia as well as to the posterior wall of the left atrium (all p<0.001). In general, postinterventional mediastinal oedematous alterations were detected in 47 patients (70%) with a mean size of 14mm (± 0.9 mm), while only 10 patients (15%) revealed a large mediastinal oedema >20mm. Oesophageal thermal lesions occurred in 3 patients (4%) including 1 deep ulceration, which coincided with a large mediastinal oedema. The two freeze protocols had a distinct impact on mediastinal lesions as mean size of oedematous alterations and occurrence of large mediastinal oedema were significantly increased in Group A vs. Group B (17 mm vs. 11 mm, p<0.001; 26% vs. 6%, p=0.029). Furthermore, every oesophageal lesion was detected in patients in group A. Nonetheless, no major complication occurred in either group.

Conclusions
The present prospective study clearly demonstrates a significant impact of freeze protocol on post-interventional mediastino-oesophageal alterations. A TTI-guided protocol employing 2nd generation cryoballoon reduces mediastino-oesophageal lesions and may reduce complications.

Acknowledgement/Funding
This study was supported by Medtronic by an unrestricted grant (A 1351459).
P575Merging technologies to provide Mexico an innovative nationwide AMI management network
Authors: Mehta S , Botelho R , Fernandez F , Alcocer Gamba M , De Los Rios O , Ricalde A , Acosta H , Villagra L , Perin M , Feres F , Frauenfelder A , Matheus C , Ceschim M , Pinto G , Mazzini J 
Published: October 2019

Abstract

Background
“Cόdigo Infarto”, the vast patient-centric, app-based, educational crusade of the Mexican Society of Interventional Cardiology (SOCIME) has been combined with the Latin America Telemedicine Infarct Network (LATIN) to create a comprehensive, national AMI program for Mexico.

Purpose
To demonstrate the benefits of amalgamating educational initiatives of national cardiology societies with a global telemedicine program for improving AMI management.

Methods
“Cόdigo Infarto” App connects patients to a network of several hundred cardiologists and 250 Primary PCI-capable labs. LATIN provides the partnership with its robust telemedicine platform, a hub-spoke strategy that supports patient's access to appropriate medical management. Remotely located experts, in Colombia, provide urgent EKG diagnosis via tele-consultation to the entire LATIN Mexico network. They activate ambulance dispatch and implement guideline-based protocols.

Results
Numerous “Cόdigo Infarto” sites have incorporated LATIN to provide a simple and accelerated management of AMI patients. Currently, the partnership (7 hubs, 78 spokes) has screened 19,886 patients. A total of 359 STEMI cases (1.8%) have been diagnosed; 118 patients (33%) were urgently reperfused, Primary PCI was performed in 74% of the latter cases. D2B time was 41 min. Reasons for the lack of treatment include delayed presentation, lack of ICU beds and insurance denials. Currently, these constraints are being methodically probed. Updated results will be available at time of presentation.

Conclusions
The synergy of the AMI initiative for Mexico provides a template for similar initiatives in developing countries.
P588Flow profile for a better non-invasive pressure drop in CoA
Authors: Fernandes J , Faraci A , Sotelo J , Urbina J , Bertoglio C , Uribe S , Nordsletten D A , Lamata P 
Published: October 2019

Abstract

Introduction
In cardiovascular obstructions, as Coarctation of the Aorta (CoA), guidelines recommend treatment based on a relevant pressure drop (ΔP). Diagnostic ΔP is estimated by simplified Bernoulli (SB) and is measured as peak-to-peak (PtP) ΔP via catheterization. The divergences amid methods are understood, but it is common practice to widely and positively accept both as valid diagnostic. Recently, simplified advective work-energy relative pressure (SAW) to correct SB by considering the full velocity profile for the ΔP computation.

Purpose
To verify the correctness of peak flow derived pressure drop via maximal velocity (SB), and full flow profile (SAW) versus clinical gold-standard PtP ΔP in a CoA phantom.

Methods
An MRI-compatible and pulsatile CoA phantom was built and tested in eight configurations, with four levels of obstruction (9, 11 and 13 mm CoA diameter and no CoA) under two flow regimes (stress and normal). The ΔP was measured via catheterization between ascending and in descending aorta (DA) as instantaneous and as PtP. Also, MRI 4D-flow velocity vector fields were acquired, enabling the ΔP estimation by SB and SAW at effective orifice area (EOA) and DA catheterization locations. at the point of the effective orifice area (EOA) and at DA catheterization location.

Results
The disparity in ΔP illustrate the fundamental differences between methods (figure and table). Catheterised instant and PtP ΔPs are similar for the CoA phantom configurations, where SB and SAW are valid. The lesser the obstruction, the greater is the temporal acceleration contribution to the ΔP and discrepancies between methods arise. As recognised, SB is an overestimation of the catheterization measurements. The most equivalent ΔPs are the catheterization PtP and SAW. Velocity-based ΔPs (SB and SAW) show a drop in performance when the velocity is captured at the DA instead of the right EOA point, illustrating the sensitivity to the acquisition location.
Peak ΔPs per method and per phantom 9mm CoA 11mm CoA 13mm CoA Normal R2 Linear eq. rest stress rest stress rest stress rest stress Instant ΔP 33.4 45.7 11.5 19.6 12.1 14.5 −2.7 −12.2 0.949 y=1.12x PtP ΔP 29.3 43.5 10.0 16.0 5.8 11.2 −1.8 -3.6 – – SB EOA 37.5 52.3 13.4 22.3 6.1 11.4 1.4 1.4 0.988 y=1.23x SB DA 22.6 59.8 10.7 18.6 5.2 8.5 0.9 1.2 0.893 y=1.15x SAW EOA 29.9 51.4 11.3 19.0 4.9 9.7 0.8 0.8 0.972 y=1.11x SAW DA 11.74 28.3 5.5 9.9 2.7 4.5 0.6 0.7 0.911 y=0.56x Linear comparisons were made against gold-standard catheterised PtP ΔP.
Velocity meshes and ΔPs in cardiac cycle

Conclusions
Initial phantom evidence suggests that the non-invasive ΔP assessments based on flow should consider the full flow profile and be acquired at the point of EOA.

Acknowledgement/Funding
PIC project, European Union's Horizon 2020 Marie Skłodowska-Curie ITN Project under grant agreement No 764738
P589Assessment of cardiac reverse remodelling following mitral valve repair and mitral valve replacement in degenerative mitral regurgitation: a cardiovascular magnetic resonance study
Authors: Chew P G , Dobson L E , Garg P , Richards F J L , Foley J R , Fent G J , Brown L A E , Saunderson C E D , Das A , Kidambi A , Levelt E , Swoboda P P , Dall'armellina E , Plein S , Greenwood J P 
Published: October 2019

Abstract

Background
Mitral valve (MV) repair is currently recommended over replacement (1). The guidelines suggesting this are however based on historic evidence which compared outdated techniques of MV replacement. Recent data cast doubts on its validity in the current era of chordal-preservation techniques in MV replacement.

Purpose
Using cardiovascular magnetic resonance (CMR) imaging, this study aimed to assess the impact of MV repair and MV replacement on cardiac left ventricular (LV) reverse remodelling.

Methods
65 patients with moderate-severe and severe mitral regurgitation (MR) were prospectively recruited. Of these, 37 patients (59% men, 65±15 years) to date with paired CMR scans at baseline and at 6 months were evaluated. Patients either underwent MV repair (n=9), MV replacement (n=10) or watchful waiting (n=18). The CMR protocol included cines for left ventricle (LV), left atria (LA), and aortic flow assessment. The LA and LV parameters, and MR fraction were analysed.

Results
At 6 months, both the MV repair and replacement groups exhibited a reduction in LV end-diastolic volume (LVEDV) and LA volumes when compared to the control group. The indexed LVEDV decreased significantly from 129±33ml/m2 to 99±37ml/m2, p<0.001 in the repair group, from 118±24ml/m2 to 90±26ml/m2, p<0.001 in the replacement group and remained unchanged in the control group 115±25ml/m2 to 113±25ml/m2, p=0.53. The absolute reduction in indexed LVEDV was not significantly different between the repair and replacement groups (−30±15ml/m2 vs −29±19ml/m2, repair vs replacement, p=1.00). Similarly, both surgical groups also sustained an equal degree of LA size reduction (−42±26ml/m2 vs −36±23ml/m2, repair vs replacement; p=1.00). There was a decline in the global postoperative LV ejection fraction (Table 1). The degree of reduction in LV ejection fraction however did not differ between the repair and replacement group (−9±6% vs −6±8%, repair vs replacement; p=1.00). Those undergoing surgery experienced a significant reduction in their MR severity, although those with replacement had a more effective reduction in MR severity (MR fraction for repair: 47±9% to 15±10%, p<0.001 vs replacement: 41±13% to 5±4%, p<0.001).

Conclusion
MV surgery leads to atrial and left ventricular reverse remodelling, and a decline in global LV ejection fraction. In this small series, MV replacement with chordal preservation showed similar cardiac reverse remodelling benefits to MV repair. Although residual MR is often seen following repair, this did not lead to less favourable cardiac reverse remodelling.

Acknowledgement/Funding
Leeds NIHR infrastructure
P599Native T1 mapping is useful for detection of myocardial fibrosis in cases with ischemic and non-ischemic myocardial diseases
Authors: Goto H , Takaoka H , Sakai T , Ochi S , Wakabayashi S , Ishikawa K , Kanaeda T , Daimon M , Ueda M , Funabashi N , Sano K , Kobayashi Y 
Published: October 2019

Abstract

Background
Evaluation of myocardial fibrosis (MF) as late gadolinium enhancement (LGE) on MRI is useful for differential diagnosis of various myocardial diseases and prediction of future adverse cardiac events in some specific myocardial diseases. Gadolinium contrast is contraindicated for cases with severe renal dysfunction, therefore non contrast MRI is necessary for detection of MF in cases with both myocardial disease and severe renal dysfunction.

Purpose
We aimed to evaluate diagnostic accuracy of native T1 mapping for detection of MF compared with LGE in cases with various myocardial diseases, including ischemic and non-ischemic myocardial diseases.

Methods
We selected consecutive 40 patients who were suspected of having various myocardial diseases and underwent cardiac MRI, using 1.5T MRI (Ingenia, Philips) in 10 cases (25%) or 3T MRI (Ingenia, Philips) in 30 cases (75%), including native T1 mapping (without contrast) and LGE using contrast media from Jan 2018 to Feb 2019 in our institution. We evaluated diagnostic accuracy for detection of MF in left ventricular myocardium (LVM) of native T1 mapping image compared with LGE as the gold standard, in a patient-based and segment-based analysis. In T1 mapping images, segmental high T1 lesions were defined as MF. In a segment-based analysis, MF was evaluated using 17 LVM segments model in American Heart Association.

Results
MF was detected in 139 LVM segments in 25 (63%) cases. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of native T1 mapping for detection of MF were 90%, 89%, 95%, 80% and 90% in a patient-based analysis, and 63%, 96%, 84%, 89% and 88% in a segment-based analysis (left figure). Native T1-values of LVM with MF were significantly higher than LVM without LGE (1351±79 vs 1093±124 in 1.5T and 1562±131 vs 1291±43 in 3T) (p<0.05 and p<0.01). Interobserver agreement of native T1 mapping and LGE were not significantly different (0.88 and 0.89, P=0.70). Overall diagnostic accuracy of native T1 mapping for detection of MF in a patient-based analysis, was not significantly different in between the cases with ischemic (n=18) and non-ischemic (n=22) myocardial disease (90% and 83.3%, P=0.10).

Conclusion
Native T1 mapping (without contrast) is useful for detection of MF in various myocardial diseases and high diagnostic accuracy is expected especially in a patient-based analysis.
P602Septal function and viability determine response to cardiac resynchronization therapy
Authors: Aalen J , Donal E , Larsen C K , Duchenne J , Kongsgaard E , Hopp E , Penicka M , Galli E , Voigt J U , Smiseth O A 
Published: October 2019

Abstract

Introduction
Cardiac resynchronization therapy (CRT) has evolved as an important treatment in patients with symptomatic heart failure, reduced left ventricular (LV) ejection fraction and wide QRS. However, as one third of patients do not benefit from the therapy, there is need for better selection criteria. Previous studies have shown an association between recovery of septal function and response to CRT.

Purpose
To test the hypothesis that septal dysfunction in the absence of scar predicts response to CRT.

Methods
In 121 patients undergoing CRT implantation according to current European Society of Cardiology guidelines, we performed speckle-tracking echocardiography and estimated LV pressure non-invasively based on a method recently innovated in our lab. Pressure-strain analysis was used to calculate myocardial work. Septal dysfunction with asymmetric LV workload was calculated as the difference between LV lateral wall and septal work. Late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR) was performed to assess septal scar. CRT response was defined as ≥15% reduction of LV end systolic volume by echocardiography at 6 months follow-up.

Results
Eighty-eight patients (73%) responded to CRT at 6 months follow-up. Multivariate logistic regression analysis including lateral-to-septal work difference, septal scar, QRS duration and QRS morphology found that only lateral-to-septal work difference and septal scar were significant predictors of CRT response (both p<0.005). Using logistic regression and receiver operating characteristic (ROC) curve analysis, we found that the combined approach of these two parameters identified CRT responders with a sensitivity of 86% and a specificity of 82%. The area under the curve (AUC) for CRT response prediction was 0.85 (95% CI: 0.76–0.94) (Figure). In comparison, the AUC value for QRS duration was 0.63 (95% CI: 0.52–0.75). Furthermore, for the subgroup of patients with QRS duration 120–150 ms (n=27), the AUC value for lateral-to-septal work difference in combination with septal scar was 0.90 (95% CI: 0.78–1.00).

Conclusions
A multimodality approach with strain echocardiography and LGE-CMR was able to detect CRT responders with high accuracy, also in the subset of patients with intermediate QRS duration. A dysfunctional but viable septum appears to be an ideal target for CRT.