bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma
Authors: Meng Xinyao , Fang Erhu , Zhao Xiang , Feng Jiexiong 
Published: March 2020

AbstractBackgroundThe association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown.ObjectiveTo identify prognostic lncRNAs involved in the spontaneous regression of NB.MethodsDifferential expression analyses were performed between those samples with an outcome of death in stage 4 NB group and those samples with an outcome of survival in stage 4S NB group in two independent public datasets, respectively. Univariate Cox proportional hazard regression survival analysis was performed in each of the entire cohort to identify those lncRNAs significantly associated with overall survival (OS). Those lncRNAs independently associated with OS were then identified by multivariate Cox survival analysis and used to construct an lncRNA risk score.ResultsA total of 20 differentially expressed and survival‐related lncRNAs were identified sharing between the two independent cohorts. The expression of each of these 20 lncRNAs was significantly correlated with the expression of NTRK1, which is a well‐known factor involved in NB spontaneous regression. Four lncRNAs (LNC00839, FIRRE, LOC283177, and LOC101928100) were identified to be significantly associated with survival independent with each other and a four‐lncRNA signature risk score was constructed. Patients with high lncRNA signature risk score had a significantly poorer OS and event‐free survival than those with low lncRNA signature risk score. The four‐lncRNA signature has a good performance in predicting survival independent with MYCN amplification (nonamplified vs amplified), age status (<18 months vs ≥18 months), risk status (low risk vs high risk), and International Neuroblastoma Staging System (INSS) stage (INSS 1/2/3/4S vs INSS 4).ConclusionsWe identified 20 survival‐related lncRNAs that might be associated with the spontaneous regression of NB and developed a four‐lncRNA signature risk score. The four‐lncRNA signature is an independent prognostic factor for survival of NB patients.
Prognostic stratification of molecularly and clinically distinct subgroup in children with acute monocytic leukemia
Authors: Liu Li‐Peng , Zhang Ao‐Li , Ruan Min , Chang Li‐Xian , Liu Fang , Chen Xia , Qi Ben‐Quan , Zhang Li , Zou Yao , Chen Yu‐Mei , Chen Xiao‐Juan , Yang Wen‐Yu , Guo Ye , Zhu Xiao‐Fan 
Published: March 2020

AbstractBackgroundThe prognosis of children with acute monocytic leukemia (AML‐M5) remains unsatisfactory and the risk profile is still controversial. We aim to investigate the prognostic value of clinical and cytogenetic features and propose a new risk stratification in AML‐M5 children.MethodsWe included 132 children with AML‐M5. Overall survival (OS) and progression‐free survival (PFS) were documented. Cox regression was performed to evaluate the potential risk factors of prognosis.ResultsThe 5‐year‐OS was 46.0% (95% confidence intervals, 41.6%‐50.4%) in all patients. There was significantly lower OS in the age ≤ 3 years old (P = .009) and hyperleukocytosis (P < .001). The FMS‐like tyrosine kinase 3 (FLT3)‐internal tandem duplication (ITD) and MLL‐rearrangement carriers were associated with fewer survivors in all patients (37.1% and 36.7%) and chemotherapy‐only group (19.0% and 35.0%). Notably, the number of survivor with MLL‐rearrangement did not increase in hematopoietic stem cell transplant (HSCT) group. According to the Cox regression analysis, HSCT was a significantly favorable factor (P = .001), while hyperleukocytosis, age ≤ 3 years old, and BM blast ≥ 70% adversely affected the OS in all patients (all P < .05). Additionally, FLT3‐ITD was a risk factor for OS in the chemotherapy‐only group (P = .023), while hyperleukocytosis and age ≤ 3 years independently contributed to poor PFS (both P < .05). In comparison to the standard‐risk group, significant poorer outcome was found in the high‐risk group (both P < .005).ConclusionsWe propose that AML‐M5 children with any of MLL‐rearrangement, FLT3‐ITD, hyperleukocytosis, BM blast ≥ 70%, or age ≤ 3 years old are classified into the high‐risk group, and HSCT is beneficial especially in patients with FLT3‐ITD mutation, hyperleukocytosis, and age ≤ 3 years old. Importantly, the choice of HSCT should be made more carefully in children with MLL‐rearrangement for its suboptimal performance.
Yldiide Ligands as Building Blocks for Polynuclear Coinage Metal Complexes: Metal Squares, Triangles and Chains
Authors: Johnson Alice , Gimeno M. Concepción 
Published: March 2020

AbstractYldiides have unique electronic properties and donor abilities, but as ligands in transition metal complexes they are scarcely represented in the literature. Here, the controlled synthesis of a series of polynuclear gold yldiide complexes derived from triphenyl(cyanomethyl)phosphonium bromide, [Ph3PCH2CN]Br, under mild conditions is described. Anionic dinuclear NBu4[(AuX)2{C(CN)PPh3}] (X=Cl, C6F5) or trinuclear derivatives NBu4[Au3X2{C(CN)PPh3}] bearing terminal chloride or pentafluorophenyl groups and bridging yldiide ligands have been prepared. These compounds evolve in solution giving rise to the formation of an unprecedented tetrameric gold cluster, [Au4{C(CN)PPh3}4], by the loss of the gold complex NBu4[AuX2]. This gold cluster can also be prepared in high yield by a transmetalation reaction from the analogous tetrameric silver cluster, and two geometric isomers have been characterised, their formation dependent on the synthetic route. The triphenylphosphonium cyanomethyldiide ligand has also been used to build different dinuclear and trinuclear cationic complexes bearing phosphine or diphosphine ancillary ligands and bridging yldiide moieties. Further coordination through the cyano group of the yldiide ligand gives heterometallic trinuclear or pentanuclear derivatives. Structural characterisation of many of these compounds reveals the presence of complex molecular systems stabilised by gold⋅⋅⋅gold interactions and bridging yldiide ligands.
Ternary Organic Solar Cells Based on Two Non‐fullerene Acceptors with Complimentary Absorption and Balanced Crystallinity
Authors: Xie Lan , Yang Chen , Zhou Ruimin , Wang Zhen , Zhang Jianqi , Lu Kun , Wei Zhixiang 
Published: March 2020

Summary of main observation and conclusionThe ternary blend structure has been demonstrated as an effective approach to increase the power conversion efficiency of organic solar cells. An effective approach to enhance the power conversion efficiency of ternary solar cells is based on two non‐fullerene acceptors with complimentary absorption range and balanced crystallinity. In this work, we have introduced a high crystallinity small‐molecule acceptor, named C8IDTT‐4Cl with appropriate alkyl side chains into a low crystalline blend of conjugated polymer donor PBDT‐TPD and fused‐ring electron acceptor ITIC‐4F. A ternary device based on the blend PBDT‐TPD:ITIC‐4F:C8IDTT‐4Cl exhibits a best power conversion efficiency of 9.51% with a simultaneous improvement of the short‐circuit current density to 18.76 mA·cm–2 and the fill factor up to 67.53%. The absorption onset for C8IDTT‐4Cl is located at 900 nm, so that the well complementary light absorption is beneficial to the photocurrent. In addition, the existence of high crystallinity C8IDTT‐4Cl in the ternary device is found helpful to modulate crystallinity, improve heterojunction morphologies and stacking structure, therefore to realize higher charge mobility and better performance.
Impelling TLR9: Road to perspective vaccine for visceral leishmaniasis
Authors: Tiwari Rohit Kumar , Gupta Chhedi Lal , Bajpai Preeti 
Published: March 2020

AbstractRecent trends in immunotherapy have shown enthusiasm in exploring Toll‐like receptors (TLRs) for designing therapeutical interventions against numerous deadly diseases. TLRs are subfamily of pathogen recognition receptor playing pivotal role in innate immunity. TLR9 is one such critical member belonging to intracellular TLRs which is associated with mounting inflammatory response in response to intruders. Explorative studies have shown CG motifs from the prokaryotic origin as activators of TLR9 culminating in the expression of NFκB. These CG rich short stranded DNA sequences have been further delineated into different classes based on their structural specificities and immunomodulatory properties. Here we discuss the progress of how activation of TLR9 can be utilized with novel parasitic CpG islands to function as potential adjuvants specifically against protozoan parasitic diseases primarily visceral leishmaniasis caused by Leishmania donovani.
Electrophysiological signatures of visual statistical learning in 3‐month‐old infants at familial and low risk for autism spectrum disorder
Authors: Marin Andrew , Hutman Ted , Ponting Carolyn , McDonald Nicole M. , Carver Leslie , Baker Elizabeth , Daniel Manjari , Dickinson Abigail , Dapretto Mirella , Johnson Scott P. , Jeste Shafali S. 
Published: March 2020

AbstractVisual statistical learning (VSL) refers to the ability to extract associations and conditional probabilities within the visual environment. It may serve as a precursor to cognitive and social communication development. Quantifying VSL in infants at familial risk (FR) for Autism Spectrum Disorder (ASD) provides opportunities to understand how genetic predisposition can influence early learning processes which may, in turn, lay a foundation for cognitive and social communication delays. We examined electroencephalography (EEG) signatures of VSL in 3‐month‐old infants, examining whether EEG correlates of VSL differentiated FR from low‐risk (LR) infants. In an exploratory analysis, we then examined whether EEG correlates of VSL at 3 months relate to cognitive function and ASD symptoms at 18 months. Infants were exposed to a continuous stream of looming shape pairs with varying probability that the shapes would occur in sequence (high probability‐deterministic condition; low probability‐probabilistic condition). EEG was time‐locked to shapes based on their transitional probabilities. EEG analysis examined group‐level characteristics underlying specific components, including the late frontal positivity (LFP) and N700 responses. FR infants demonstrated increased LFP and N700 response to the probabilistic condition, whereas LR infants demonstrated increased LFP and N700 response to the deterministic condition. LFP at 3 months predicted 18‐month visual reception skills and not ASD symptoms. Our findings thus provide evidence for distinct VSL processes in FR and LR infants as early as 3 months. Atypical pattern learning in FR infants may lay a foundation for later delays in higher level, nonverbal cognitive skills, and predict ASD symptoms well before an ASD diagnosis is made.
A forest‐specialist carnivore in the middle of the desert?Comments on Anabalon et al. 2019
Authors: Moreira‐Arce Darío , Silva‐Rodríguez Eduardo A. , Napolitano Constanza , D’Elía Guillermo , Cabello Javier , Millán Javier , Hidalgo‐Hermoso Ezequiel , Farías Ariel A. 
Published: March 2020

AbstractWe present comments on an article recently published in Ecology and Evolution (“High‐resolution melting of the cytochrome B gene in fecal DNA: A powerful approach for fox species identification of the Lycalopex genus in Chile”) by Anabalon et al. that reported the presence of Darwin's fox (Lycalopex fulvipes), a temperate forest specialist, in the hyperarid Atacama Desert of northern Chile. We argue that this putative record lacks ecological support in light of ongoing research on this endangered species, and contains numerous methodological flaws and omissions related to the molecular identification of the species. Based on these issues, we suggest the scientific community and conservation decision‐makers disregard the alleged presence of the Darwin's fox in the Atacama Desert.
Evaluation of high‐sensitivity C‐reactive protein and uric acid in vericiguat‐treated patients with heart failure with reduced ejection fraction
Authors: Kramer Frank , Voss Sebastian , Roessig Lothar , Igl Bernd‐Wolfgang , Butler Javed , Lam Carolyn S.P. , Maggioni Aldo P. , Shah Sanjiv J. , Pieske Burkert 
Published: March 2020

AbstractAimsThe effects of vericiguat vs. placebo on high‐sensitivity C‐reactive protein (hsCRP) and serum uric acid (SUA) were assessed in patients with heart failure with reduced ejection fraction (HFrEF) in the Phase 2 SOCRATES‐REDUCED study (NCT01951625).Methods and resultsChanges from baseline hsCRP and SUA values at 12 weeks with placebo and vericiguat (1.25 mg, 2.5 mg, 5.0 mg and 10.0 mg, respectively) were assessed. The probability of achieving an hsCRP value of ≤3.0 mg/L or SUA value of <7.0 mg/dL at week 12 was tested. Median baseline hsCRP and SUA levels were 3.68 mg/L [interquartile range (IQR) 1.41–8.41; n = 335] and 7.80 mg/dL (IQR 6.40–9.33; n = 348), respectively. Baseline‐adjusted mean percentage changes in hsCRP were 0.2%, −19.5%, −24.3%, −25.7% and −31.9% in the placebo and vericiguat 1.25 mg, 2.5 mg, 5.0 mg and 10.0 mg groups, respectively; significance vs. placebo was observed in the vericiguat 10.0 mg group (P = 0.035). Baseline‐adjusted mean percentage changes in SUA were 5.0%, −1.3%, −1.1%, −3.5% and −5.3% in the placebo, and vericiguat 1.25 mg, 2.5 mg, 5.0 mg and 10.0 mg groups, respectively; significance vs. placebo was observed in the 5.0 mg and 10.0 mg groups (P = 0.0202 and P = 0.004, respectively). Estimated probability for an end‐of‐treatment hsCRP value of ≤3.0 mg/L and SUA value of <7.0 mg/dL was higher with vericiguat compared with placebo. The effect was dose‐dependent, with the greatest effect observed in the 10.0 mg group.ConclusionsVericiguat treatment for 12 weeks was associated with reductions in hsCRP and SUA, and a higher likelihood of achieving an hsCRP value of ≤3.0 mg/L and SUA value of <7.0 mg/dL.
Analysis of the relationship between LSTM network traffic flow prediction performance and statistical characteristics of standard and nonstandard data
Authors: Doğan Erdem 
Published: March 2020

AbstractThe effectiveness of road traffic control systems can be increased with the help of a model that can accurately predict short‐term traffic flow. Therefore, the performance of the preferred approach to develop a prediction model should be evaluated with data sets with different statistical characteristics. Thus a correlation can be established between the statistical properties of the data set and the model performance. The determination of this relationship will assist experts in choosing the appropriate approach to develop a high‐performance short‐term traffic flow forecasting model. The main purpose of this study is to reveal the relationship between the long short‐term memory network (LSTM) approach's short‐term traffic flow prediction performance and the statistical properties of the data set used to develop the LSTM model. In order to reveal these relationships, two different traffic prediction models with LSTM and nonlinear autoregressive (NAR) approaches were created using different data sets, and statistical analyses were performed. In addition, these analyses were repeated for nonstandardized traffic data indicating unusual fluctuations in traffic flow. As a result of the analyses, LSTM and NAR model performances were found to be highly correlated with the kurtosis and skewness changes of the data sets used to train and test these models. On the other hand, it was found that the difference of mean and skewness values of training and test sets had a significant effect on model performance in the prediction of nonstandard traffic flow samples.
Study of mechanism and kinetic modeling of CO hydrogenation reaction over the impregnated Co‐Ni/Al2O3 catalyst
Authors: Arsalanfar Maryam , Fatemi Mahdi , Mirzaei Nima , Abdouss Majid , Rezazadeh Esmaeil 
Published: March 2020

AbstractAn investigation of the kinetic and mechanism of CO hydrogenation reaction was performed on impregnated Co‐Ni/Al2O3. Determination of kinetic parameters from the experiments was carried out in a micro fixed‐bed reactor. Kinetic evaluations were performed under various operational conditions of T = 473–673 K, p = 1–14 bar, H2/CO = 1–3, and GHSV = 4,500 hr−1. Kinetic models and rate equations for CO consumption were obtained by using two main‐type rate equations of Langmuir‐Hinshelwood‐Hougen‐Watson (LHHW) and Eley‐Rideal (ER). Estimation of various kinetic parameters was performed using a nonlinear regression method. According to the obtained experimental results and using statistical criteria, one kinetic expression based on the LHHW mechanism (‐rCO = kp.bCO.PCO. bH2. PH2/[1+ bCO.PCO + bH2.PH2]2) was chosen as the best‐fitted model. For this fitted model, the activation energy was found to be 109.2 kJ/mol. Characterization of the catalyst was also performed using X‐ray diffraction (XRD), BET, scanning electron microscopy (SEM), and energy‐dispersive x‐ray spectrometer (EDS) techniques.
Reactivity of some 3‐substituted‐6,8‐dimethylchromones toward some nucleophilic reagents
Authors: Badran Al‐Shimaa , El‐Gohary Nasser M. , Ibrahim Magdy A. , Hashiem Salsabeel H. 
Published: March 2020

AbstractThe reactivity of 3‐substituted‐6,8‐dimethylchromone derivatives 1‐5 was investigated toward selected nucleophilic reagents namely; 3‐amino‐1,2,4‐triazole, 2‐aminobenzimidazole, 7‐chloro‐4‐hydrazinoquinoline, and 5,6‐diphenyl‐3‐hydrazino‐1,2,4‐triazine. These nucleophiles were allowed to react with 6,8‐dimethylchromone‐3‐carboxaldehyde (1) through condensation with the aldehyde group with opening of γ‐pyrone ring giving compounds 6, 7, 10, and 11. Reactions with 6,8‐dimethylchromone‐3‐carbonitrile (2), and 6,8‐dimethylchromone‐3‐carboxylic acid (3) occur via attack at position 2 in both compounds followed by cycloaddition onto the nitrile function (in case of carbonitrile 2) or decarboxylation and cyclocondensation with the carbonyl group (in case of carboxylic acid 3). The current nucleophilic reagents reacted with simple condensation products 4 and 5, in boiling dioxane, through nucleophilic addition at the exocyclic vinyl bond followed by addition at the CN group giving 6,8‐dimethylchromone linked various heterocyclic systems 20‐27.
Ethnic variability in newborn metabolic screening markers associated with false‐positive outcomes
Authors: Peng Gang , Tang Yishuo , Gandotra Neeru , Enns Gregory M. , Cowan Tina M. , Zhao Hongyu , Scharfe Curt 
Published: March 2020

AbstractNewborn screening (NBS) programmes utilise information on a variety of clinical variables such as gestational age, sex, and birth weight to reduce false‐positive screens for inborn metabolic disorders. Here we study the influence of ethnicity on metabolic marker levels in a diverse newborn population. NBS data from screen‐negative singleton babies (n = 100 000) were analysed, which included blood metabolic markers measured by tandem mass spectrometry and ethnicity status reported by the parents. Metabolic marker levels were compared between major ethnic groups (Asian, Black, Hispanic, White) using effect size analysis, which controlled for group size differences and influence from clinical variables. Marker level differences found between ethnic groups were correlated to NBS data from 2532 false‐positive cases for four metabolic diseases: glutaric acidemia type 1 (GA‐1), methylmalonic acidemia (MMA), ornithine transcarbamylase deficiency (OTCD), and very long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD). In the result, 79% of the metabolic markers (34 of 43) had ethnicity‐related differences. Compared to the other groups, Black infants had elevated GA‐1 markers (C5DC, Cohen's d = .37, P < .001), Hispanics had elevated MMA markers (C3, Cohen's d = .13, P < .001, and C3/C2, Cohen's d = .27, P < .001); and Whites had elevated VLCADD markers (C14, Cohen's d = .28, P < .001, and C14:1, Cohen's d = .22, P < .001) and decreased OTCD markers (citrulline, Cohen's d = −.26, P < .001). These findings correlated with the higher false‐positive rates in Black infants for GA‐1, in Hispanics for MMA, and in Whites for OTCD and for VLCADD. Web‐based tools are available to analyse ethnicity‐related changes in newborn metabolism and to support developing methods to identify false‐positives in metabolic screening.
Sleep, brain development, and autism spectrum disorders: Insights from animal models
Authors: Wintler Taylor , Schoch Hannah , Frank Marcos G. , Peixoto Lucia 
Published: March 2020

AbstractSleep is an evolutionarily conserved and powerful drive, although its complete functions are still unknown. One possible function of sleep is that it promotes brain development. The amount of sleep is greatest during ages when the brain is rapidly developing, and sleep has been shown to influence critical period plasticity. This supports a role for sleep in brain development and suggests that abnormal sleep in early life may lead to abnormal development. Autism spectrum disorder (ASD) is the most prevalent neurodevelopmental disorder in the United States. It is estimated that insomnia affects 44%–86% of the ASD population, predicting the severity of ASD core symptoms and associated behavioral problems. Sleep problems impact the quality of life of both ASD individuals and their caregivers, thus it is important to understand why they are so prevalent. In this review, we explore the role of sleep in early life as a causal factor in ASD. First, we review fundamental steps in mammalian sleep ontogeny and regulation and how sleep influences brain development. Next, we summarize current knowledge gained from studying sleep in animal models of ASD. Ultimately, our goal is to highlight the importance of understanding the role of sleep in brain development and the use of animal models to provide mechanistic insight into the origin of sleep problems in ASD.
High refresh rate and low power consumption AMOLED panel using top‐gate n‐oxide and p‐LTPS TFTs
Authors: Yonebayashi Ryo , Tanaka Kohei , Okada Kuniaki , Yamamoto Kaoru , Yamamoto Keiichi , Uchida Seiichi , Aoki Tomohisa , Takeda Yujiro , Furukawa Hiroaki , Ito Kazuatsu , Katoh Hiromi , Nakamura Wataru 
Published: March 2020

AbstractA pixel circuit and a gate driver on array for light‐emitting display are presented. By simultaneously utilizing top‐gate n‐type oxide and p‐type low‐temperature polycrystalline silicon (LTPS) thin‐film transistors (TFTs), the circuits provide high refresh rate and low power consumption. An active‐matrix LED (AMOLED) panel with proposed circuits is fabricated, and driving at various refresh rate ranging from 1 to 120 Hz could be achieved.