bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framework for Client-Server Distributed Database System for Federal Road Safety Commission Nigeria
Authors: Tuperekiye E. Sese 
Published: June 2020

In recent years it has been observed that the federal road safety commission FRSC has been having some challenges on how to handle traffic rule and traffic offences committed by road users both commercial and private. Based on the in ability of the FRSC to handle these problems this paper critically looked into the behavioural pattern of the drivers towards traffic rules and offences committed and found that there was a great need for the Organisation to have a good database, that will be able to keep records of traffic offences and offenders, which can be called upon at any time on reference basis. The aim of this study is to create a distributed Federal Road Safety commission traffic offence system that can access data from any state of the Federation. The system consists of a relational database of FRSC variables which could be shared by the various States and Local Government Areas in the country. Each of the local government area will form a website, and the database will be hosted by the server at the Federal Road Safety Commission Head Quarters at Abuja and at the various state capital. . All LGAs will access the database via a distributed network. The client/server distributed network architecture is used in the design and implementation of the system. The system is capable of monitoring all road offences and traffic offenders records at all levelsfrom any part of the country and generation of reports concerning offenders and also access information from the local government at all times.
Ancient History of Arabian Peninsula and Semitic Arab Tribes
Authors: Mohd. Shamsuddin Salahuddin , Hj. Ahmad Siti Sara Binti 
Published: June 2020

In this article we introduced first the ancient history of Arabian Peninsula, and pre-Islamic era and then we focused a spot light on the people of Arabian Peninsula, highlighting the four waves of migration of Semitic Arabs from the southern to northern Arabian Peninsula, then we mentioned the situation of Northern Arabs and their tribal fanaticism, then we differentiated between Qahtaniyya and Adnaniyya Arab tribes including their three Classes: Destroyed Arab, Original Arab and Arabized Arab. We also explained the tribal system in the pre-Islamic era, indicating the status of four pillars of the tribal system:

Integration and alliance among the tribes
Tribal Senate or Parliament
Tribes and sovereignty over the tribes
Members of the tribes and their duties towards their tribal society

In the end we described the master of Arab tribe who was the brightest person had a long experience and often had inherited his sovereignty from his fathers to achieve a high status, but it does not mean that he had a broad sovereignty, as his sovereignty was symbolic. He had no rights except that he was obeyed and respected by everyone. We tried to mention all these points with some further details.
Ethnic Memory And Historical Injustices In Nigeria
Authors: Olusegun Atere Clement 
Published: June 2020

It is a known fact that not few Nigerians believed that the country has committed atrocities against her citizen and this has caused mutual suspicion, deep divisions, inter-ethnic wrangling, and unending disputations in this ethnically and geographically diverse nation.
The aim of this paper is to provide fresh insight on the causality of the deep mistrust and mutual suspicion among the various ethnic groups which in turn has caused the Nigeria nation much needed unity. The paper argued that recurring memorialization of unresolved historical injustices has been a potent poison to the glowing of communal and organic wellbeing of the nation.
The paper concluded that the government must redress the past historical injustices, explore how Nigerians together can search for common memories to meet present needs, and allow the various ethnic group to come to terms with their past. The paper recommended new Truth and Reconciliation Commission
Interferences in the measurement of circulating phosphate: a literature review
Authors: Molinaris Valentina , Bianchetti Mario G. , Milani Gregorio P. , Lava Sebastiano A.G. , Bruna Roberto Della , Simonetti Giacomo D. , Faré Pietro B. 
Published: June 2020

Abstract

Background
Inorganic phosphate in blood is currently determined by the reaction with molybdate. This report aims at reviewing conditions underlying spuriously altered levels of circulating inorganic phosphate.

Content
A systematic search of the Excerpta Medica, the National Library Database and the Web of Science database was conducted without language restriction from the earliest publication date available through January 31, 2020.

Summary
For the analysis, 80 reports published in English (n = 77), French (n = 1), German (n = 1) and Spanish (n = 1) were retained. Well-documented pseudohyperphosphatemia was observed in individuals exposed to liposomal amphotericin, in patients affected by a gammopathy, in patients with hyperlipidemia and in patients with hyperbilirubinemia. An unexplained elevated inorganic phosphate level sometimes provided a clue to the diagnosis of a gammopathy. Well-documented cases of pseudohypophosphatemia were observed in patients on large amounts of intravenous mannitol. Finally, pseudohypophosphatemia was occasionally observed on treatment with liposomal amphotericin and in patients with a gammopathy.

Outlook
In order to avoid unnecessary testing and treatment, the phenomenon of spuriously altered inorganic phosphate should be recognized. An unexplained hyperphosphatemia may provide a clue to the diagnosis of a gammopathy or a severe hyperlipidemia.
The role of sex and gender in search behavior for political information on the internet
Authors: Kessler Sabrina Heike , Langmann Klara 
Published: June 2020

Abstract
Previous studies have emphasized a person’s biological sex as a factor which influences online search behavior. This study aims to investigate how people (N = 44 students) search online for political information (N = 220 search tasks) and if gendered online search exists. We examined online search behavior via eye tracking while the participants searched for information about political party positions on the Internet. A content analysis of the eye tracking data followed and was evaluated with a special focus on the role of biological sex and social gender, and the relationship of both factors with other variables, such as self-reported prior political knowledge, political interest, and Internet skills (via an online survey). The results accord with previous studies in that the sex influences the online search process. However, this relationship was partially mediated by self-reported political interest and prior knowledge. This outcome calls for a more critical use of the sex variable in reference to political online search behavior, and the inclusion of sex and gender related variables.
Migratory movements in the press of Spanish-speaking countries (2017)
Authors: Salas Luis Guerra , Sánchez María Elena Gómez 
Published: June 2020

Abstract
The aim of this article is to analyze journalistic texts on migratory movements appeared on the main newspapers of Spanish-speaking countries along 2017. The focus is put on the subjects that the newspapers highlight, the regions selected and the linguistics elections being made. The research has a multidisciplinary approach that uses the concept of representation, as being used in linguistics pragmatics and cultural anthropology. We use the database Factiva® as the starting point to collect the journalistic pieces that we use for our analysis. The search has been refined using linguistic, contextual, geographic and chronological criteria. Two sub-corpora have been built with the texts obtained through the search. One focuses strictly on Spanish press and the second one is related to the Hispanic area (seven newspapers have been chosen to build this corpus, and each one of them represents one of the seven ample dialectal areas of Spanish language). The qualitative analysis is based on the key words of each of these sub-corpora; such key words are stablished from a text-mining technique that offers the most relevant words and sentences of the first 100 texts obtained through every specific search.
Therapeutic role of metformin and troglitazone to prevent cancer risk in diabetic patients: evidences from experimental studies
Authors: Haq Muhammad Ejaz ul , Akash Muhammad Sajid Hamid , Rehman Kanwal , Khurshid Mohsin 
Published: June 2020

Abstract

Objectives
It is evident from literature that individual with diabetes mellitus is more prone to develop cancer as compared to non-diabetic one. We aimed to highlight the risk factors that trigger the tumor formation in diabetic individuals and collect evidences regarding the preventive role of anti-diabetics in cancer.

Content
A comprehensive literature was searched in English language using electronic databases including PubMed, ScienceDirect, Medline, Scopus and Embase.

Summary and outlook
Antidiabetic drugs notably metformin and troglitazone, exhibit anticancer effects. Metformin targets energy sensor pathway i. e., AMPK/mTOR which is controlled by LKB1. Whereas. troglitazone activates PPARϒ that modulate the transcription of insulin responsive gene which is essential for lipid and glucose metabolism. Adipocytes are highly expressed with PPARɣ which induce differentiation and regulate adipogenesis. Ligand-driven expression of PPARɣ in myoblast and fibroblast cell lines produces adipocyte differentiation in breast cancer. Prostate cancer that expresses PPARɣ may be suppressed by troglitazone and retinoid which inhibit their proliferation and initiate differentiation. The findings summarized here show that metformin and troglitazone may have the ability to inhibit the cancer cell proliferation via involvement of molecular pathways. This therapeutic intervention will help to control the progression of cancer in diabetic patients.
Development of a trunk motor paradigm for use in neuroimaging
Authors: Saunders Elizabeth , Clark Brian C. , Clark Leatha A. , Grooms Dustin R. 
Published: June 2020

Abstract
The purpose of this study was to quantify head motion between isometric erector spinae (ES) contraction strategies, paradigms, and intensities in the development of a neuroimaging protocol for the study of neural activity associated with trunk motor control in individuals with low back pain. Ten healthy participants completed two contraction strategies; (1) a supine upper spine (US) press and (2) a supine lower extremity (LE) press. Each contraction strategy was performed at electromyographic (EMG) contraction intensities of 30, 40, 50, and 60% of an individually determined maximum voluntary contraction (MVC) (±10% range for each respective intensity) with real-time, EMG biofeedback. A cyclic contraction paradigm was performed at 30% of MVC with US and LE contraction strategies. Inertial measurement units (IMUs) quantified head motion to determine the viability of each paradigm for neuroimaging. US vs LE hold contractions induced no differences in head motion. Hold contractions elicited significantly less head motion relative to cyclic contractions. Contraction intensity increased head motion in a linear fashion with 30% MVC having the least head motion and 60% the highest. The LE hold contraction strategy, below 50% MVC, was found to be the most viable trunk motor control neuroimaging paradigm.
Differential diagnosis and morphological and functional characteristics of atrial myxoma
Authors: Sukhorukova O. A. , Parno A. A. , Mayer V. V. , Ali-Riza A. E. , Semichev E. V. 
Published: June 2020

Right atrial myxoma is one of the rare diseases in cardiology practice. It is accompanied by an unclear clinical picture, and in most cases is asymptomatic and is an incidental finding. The article is devoted to the clinical observation of primary cardiac tumor and the difficulties of its differential diagnosis.Patient T, 58 years old, was hospitalized in a respiratory medicine center with complaints of cough with viscous sputum, weakness, fatigue, loss of appetite, shortness of breath on exertion, weight loss and sweating at night. The preliminary diagnosis was an exacerbation of chronic bronchitis. Then a space-occupying mass in the right atrium was revealed. Computed tomography imaging identified a bilateral pulmonary embolism. In the cardiac surgery department, surgical removal of the right atrial myxoma was performed.The diagnosis of right atrial myxoma was established by echocardiography, confirmed macroscopically during surgery, and then by histological verification.
Antiarrhythmic drug therapy after atrial fibrillation ablation: data of the ESC-EHRA registry
Authors: Mikhaylov E. N. , Korobchenko L. E. , Bayramova S. A. , Kharats V. E. , Kachalkova O. N. , Dmitriev A. Yu. , Batalov R. E. , Morgunov D. P. , Silin I. A. , Aleksandrovskiy A. A. , Kryzhanovskiy D. V. , Romanov A. B. , Pokushalov E. A. , Lebedev D. S. , Kuznetsov V. A. , Kolunin G. V. , Zamanov D. A. , Chetverikov S. Yu. , Yashin S. M. , Popov S. V. , Ivanitsky E. A. , Gorkov A. I. , Mamchur S. E. , Bazaev V. A. 
Published: June 2020

Aim. Catheter ablation (CA) is an effective approach for rhythm control in atrial fibrillation (AF), however antiarrhythmic therapy (AAT) remains important. There is a lack of data about long-term AAT use after CA. This study evaluates AAT after CA for AF.Material and methods. In 2012-2016, EURObservational Research Programme of Atrial Fibrillation Ablation Long-Term (EORP AFA L-T) registry was conducted, which included 476 Russian patients (57,1% — men; mean age — 57,1±8,7 years). The follow-up after CA was 12 months (available in 81,9% of patients). The use of AAT was evaluated prior to hospitalization, during hospitalization for CA, as well as at 3, 6 and 12 months of follow-up.Results. Prior to CA, 439 (92,2%) patients received AAT During CA, 459 (96,4%) patients were treated with AAT. After CA, AAT was used by 463 (97,3%), 370 (94,8%), and 307 (78,7%) patients at 3, 6 and 12 months of follow-up, respectively. There was no arrhythmia recurrence in 187 (47,9%) subjects. Among these patients, 40 (21,4%) received class IC or III AAT. The peak of AAT use was found for class IC agents within 3 months after CA (P<0,05), while for other drugs this trend was not observed. There were no factors associated with AAT usage in patients without arrhythmia recurrence after CA. A positive correlation of arrhythmia non-recurrence with a minimum number of previously used antiarrhythmic agents was revealed (RR=0,85; 95% CI 0,73-0,98; P=0,03).Conclusion. The frequency of AAT use after AF ablation is significantly reduced. However, there is a cohort of patients without documented arrhythmia recurrence still receiving AAT, which requires special attention of physicians. There were no clinical predictors of continued AAT in subjects without arrhythmia recurrence.
VIRTUOSIDAD EN ORGANIZACIONES ESCOLARES ASOCIADA AL LIDERAZGO AUTÉNTICO DE SUS AUTORIDADES
Authors: Fernando Fernando , Perugini María Laura Lupano 
Published: June 2020

El presente estudio se realizó en el marco de un ejercicio de reflexión sobre los elementos que contribuyen a fortalecer la calidad de la educación en Ecuador, desde el accionar de autoridades, docentes y estudiantes; su marco teórico de análisis fue la Psicología Positiva aplicada a la escuela como organización virtuosa. El objetivo fue identificar perfiles de organizaciones escolares percibidas como virtuosas, asociados a los niveles de liderazgo auténtico presentes en sus autoridades. Se trabajó con una muestra no probabilística de 209 autoridades educativas mediante la aplicación de las escalas de virtuosidad percibida en organizaciones escolares y liderazgo auténtico, en autoridades adaptadas a los contextos ecuatorianos. En primer lugar, se estableció la correlación presente entre las dimensiones de la virtuosidad percibida en organizaciones escolares y las dimensiones de liderazgo auténtico en autoridades; seguidamente, mediante las técnicas de conglomerados de k medias y de análisis de varianza univariado (ANOVA), se identificaron dos niveles de liderazgo auténtico y dos perfiles de organizaciones escolares virtuosas relacionados con esos niveles de liderazgo, estos son: 1) organizaciones escolares virtuosas con liderazgos auténticos fortalecidos en sus autoridades; y, 2) organizaciones escolares en camino a la virtuosidad, con liderazgos auténticos en construcción en sus autoridades.
A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer
Authors: Gatti-Mays Margaret E. , Karzai Fatima H. , Soltani Sanaz N. , Zimmer Alexandra , Green Jeffrey E. , Lee Min-Jung , Trepel Jane B. , Yuno Akira , Lipkowitz Stanley , Nair Jayakumar , McCoy Ann , Lee Jung-Min 
Published: June 2020

Abstract

Lessons Learned
Monotherapy with prexasertib demonstrated modest activity in BRCA wild-type, recurrent triple-negative breast cancer, highlighting the unmet need for combination treatment strategies. Neutropenia, anemia, and thrombocytopenia are common with the use of prexasertib but are manageable with supportive care measures. Prophylactic use of granulocyte colony stimulating factor should be considered to avoid dose reductions or treatment delays. Pharmacodynamic studies showed prexasertib treatment induced DNA damage in peripheral immune cells.

Background
Cell cycle checkpoint kinase 1 (CHK1) is a major G2/M cell cycle regulator in tumors with p53 dysfunction, such as triple-negative breast cancer (TNBC). We hypothesized the second-generation CHK1 inhibitor, prexasertib, would yield clinical activity in sporadic TNBC.

Methods
This single arm, phase II trial evaluated prexasertib at 105 mg/m2 IV every 2 weeks in patients with metastatic/recurrent TNBC. The primary endpoint was overall response rate (ORR).

Results
All nine patients enrolled were germline BRCA wild-type (BRCAwt) and had at least one prior treatment. One partial response (PR) was observed (ORR of 11.1%). Four patients experienced stable disease. The median progression-free survival (PFS) was 86 days (range 17 to 159 days). Grade 3/4 treatment-related adverse events included afebrile neutropenia (n = 8; 88.9%), anemia (n = 3; 33.3%), and thrombocytopenia (n = 1; 11.1%). Pharmacodynamic studies showed prexasertib treatment induced DNA damage in peripheral immune cells and demonstrated a decrease in activated/reinvigorated CD8 T cells; however, the one patient with a PR showed evidence of T-cell recovery.

Conclusion
Prexasertib monotherapy had modest clinical efficacy in BRCAwt TNBC. Further studies of prexasertib in combination with other agents are needed.
Yenidoğan Yoğun Bakım Ünitesinde Akut Periton Diyalizi Kullanımı ve Sonuçları
Authors: EMİROĞLU Nuriye , ALTUNHAN Hüseyin 
Published: June 2020

Öz: Amaç: Akut periton diyalizi (APD) yapılan yenidoğanların altta yatan nedenlerini ve sonuçlarını değerlendirmekGereç ve Yöntem: APD yapılan hastaların çoğunda akut böbrek
yetmezliği (ABY) (n=21, %70) ve
sepsis-dirençli metabolik asidoz (n=5, %16.7) vardı. ABY'nin diğer nedenleri renal
agenezi (n=2, %9.5), perinatal asfiksi (n=4,%19),
multikistik displastik böbrek (n=3, %13.3)
ve konjenital kalp hastalığı (n=4, %19) idi.
Ortalama diyaliz süresi 7.8±9.3 gün idi. En sık görülen komplikasyonlar kateter
tıkanıklığı (n=8, %34.8) ve kateter girişinden sızıntı (n=5, %21.7) idi.
Mortalite oranı % 70 idi; 8 hasta (%38) APD sürecinde altta yatan hastalıklar
nedeniyle öldü. Hayatta kalan 9 hastanın izlemi sırasında 3 hasta (%33.3) tam
remisyon gösterdi, ancak kalan 6 hastada kronik böbrek yetmezliği, altta yatan
metabolik hastalıklarına yönelik klinik bulgular devam etti.Bulgular: APD yapılan hastaların çoğunda akut böbrek
yetmezliği (ABY) (n=21, %70) ve
sepsis-dirençli metabolik asidoz (n=5, %16.7) vardı. ABY'nin diğer nedenleri renal
agenezi (n=2, %9.5), perinatal asfiksi (n=4,%19),
multikistik displastik böbrek (n=3, %13.3)
ve konjenital kalp hastalığı (n=4, %19) idi.
Ortalama diyaliz süresi 7.8±9.3 gün idi. En sık görülen komplikasyonlar kateter
tıkanıklığı (n=8, %34.8) ve kateter girişinden sızıntı (n=5, %21.7) idi.
Mortalite oranı % 70 idi; 8 hasta (%38) APD sürecinde altta yatan hastalıklar
nedeniyle öldü. Hayatta kalan 9 hastanın izlemi sırasında 3 hasta (%33.3) tam
remisyon gösterdi, ancak kalan 6 hastada kronik böbrek yetmezliği, altta yatan
metabolik hastalıklarına yönelik klinik bulgular devam etti.Tartışma: APD
yenidoğan yoğun bakım ünitelerinde sıklıkla kullanılan tedavi şeklidir.
Peritonit gibi hayatı tehdit eden komplikasyonları olsa da, bu tür
komplikasyonlar nispeten daha az yaygındır. APD ihtiyacı için erken tanıma ve
erken APD işleminin başlaması bu hastalarda mortalitenin azalmasına katkıda
bulunabilir.
The use of bone grafts in dental practice
Authors: Melo de Matos Jefferson David , Santos Diamantino Pedro Jacy , Sussumu Nishioka Renato , Bottino Marco Antonio , Da Rocha Scalzer Lopes Guilherme , Cabral Andrade Valdir 
Published: June 2020

Introduction: The aim of this study is to describe, via literature review, the use of bone grafts and the types most commonly used to rebuild following alveolar bone loss.
Methodology: This literature review was conducted using the following databases: Pubmed (https://www.ncbi.nlm.nih.gov/pubmed), Scielo (http://www.scielo.org/php/index.php). The keywords for the textual search were: Bone Regeneration; Alveolar Bone Grafting; Dental Research; Dentistry. The inclusion criteria were: Literature that covers the subject under study, Literature of the last five years (from 2014 until 2019), English Language, systematic review, laboratory and clinical studies. The exclusion criteria were: literature review, letter to the editor, opinion article, literature duplicated in databases and literature that did not address the variables under study.
Literature Review: 186 articles were found, but according to the inclusion criteria, only 30 were selected for this study. Bone is a specialized, vascularized and dynamic connective tissue that changes over the life of the organism. When injured, it has a unique capacity for regeneration and repair without the presence of scars, but in some situations due to the defect size, the bone tissue does not regenerate completely; thus, it is necessary to perform bone grafting procedures.
Conclusion: The use of bone grafts in dentistry is shown to be a very effective and useful resource considering its great applicability in bone reconstructions in various areas of dentistry. However, greater knowledge about the viability and
influence of biomaterials, whether associated to autogenous grafts or not, on bone repair is necessary.