bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case studies of comprehensive gas control method during fully mechanized caving of low permeability ultra-thick coal seams
Authors: Jiang Bangyou , Gu Shitan , Tan Yunliang , Zhang Guangchao , Zhang Jihua 
Published: November 2020

Abstract
Slicing fully mechanized caving mining now is a common high-efficiency mining method for ultra-thick coal seams. However, effective gas control has remained a difficulty in fully mechanized top-coal caving mining of low permeability ultra-thick coal seams. This study focused on mining of the #9-15 coal in Liuhuanggou Coal Mine, Xinjiang Province, China, and combined theoretical analyses and field test results for exploring comprehensive gas control methods for fully mechanized caving of low permeability ultra-thick coal seams. The No. (9-15)06 panel is a top slicing panel of the #9-15 coal with a mining height of 9 m, and the No. (4-5)02 goaf is located on the top of the panel. Through analysis, gas emissions in the No. (9-15)06 panel were mainly sourced from the coal wall, caving of top coal, goaf, and neighboring coal seams. A comprehensive gas control method based on source separation was proposed, which combined gas pre-drainage along the coal seam, high-position drilling on the top, pre-burial of pipes in the goaf, and pressure-balancing ventilation. Considering the poor gas pre-drainage effect for low permeability coal seams, the permeability of the coal seam was enhanced using hydraulic fracturing. According to coal seam and crustal stress distribution characteristics, the arrangement of the boreholes and backward segmented fracturing technology were designed. Field data show that coal underwent remarkable pre-fracturing under hydraulic fracturing. Mean gas pre-drainage from the boreholes was enhanced by nearly 4 times compared to the pre-hydraulic fracturing state. Finally, using the proposed comprehensive control method based on the gas sources, field tests were performed in the No. (9-15)06 panel. Field measurement data demonstrate that gas concentration in the return airflow fluctuated within a range of 0.05%~0.35%, i.e., gas concentration did not exceed the standard. The proposed gas control method can provide insightful reference for the other similar projects.
Leg Ulcers in Sickle Cell Disease: a protocol for systematic review and meta-analysis
Authors: Duru Augustine Nwakuche , Ukoma Chi-kadibia Theophilus , Okoye Helen Chioma , Nna Emmanuel Okechukwu , Iloanya Peter Chika , Ngene Samuel Osobuchi , Nnamani Amaka Obiageli , Ikegwulonu Richard Chinaza , Daboer Jonathan C , Ezeonu Chinonyelum Thecla , Onwuchekwa Eunice Chinemerem , Olaoluwa OLANIYAN Kayode , ADEOLA Olatoun Adefunke , Okeke Uchenna Ifeoma , Okoye Ifeoma Joy 
Published: November 2020

Abstract
Background: Sickle cell disease affects about 112 per 100,000 live births globally. Leg ulcer is a major and clinically challenging complication of sickle cell disease. It affects about 1.0 -75 % of SCDs with exact prevalence unknown. This study aims to determine pooled prevalence of leg ulcer in sickle cell disease as well as evaluate moderating effects of single nucleotide polymorphisms, patient’s age and sex, geographical locations, treatment modalities and expression of plasma cytokines.Methods: A search strategy is developed using MeSH, text words and entry terms. Nine databases will be searched: PuMed, African Journal Online, Embase, Google Scholar, Scopus, Cochrane Library, CINAHL, Web of Science and ResearchGate. Only observational studies, retrievable in the English language will be included. The primary outcome is the proportion of leg ulcers in sickle cell disease. The effect size is prevalence. Identified studies will be screened and selected based on inclusion criteria using EndNote version 9. Quality scores and risk of bias for individual studies will be reported. Studies will be assessed for methodological, clinical, and statistical heterogeneity. Funnel Plots will be used to assess publication bias. Extracted data items will be arranged in Microsoft Excel before exporting them to CMA software for quantitative analysis. The random model computation for pooled effect size will be used. Results including pooled prevalence, standard error, 95 % CI and subgroup analysis will be presented in forest plots. Discussion: Ethical approval will not be required since this study is based on published data. This protocol will enable reproducible and accurate estimation of pooled prevalence of leg ulcers and effects of moderators in sickle cell disease. The data from such review will stimulate further research into leg ulcers in SCD. The final report of this study will be published in a peer-reviewed journal and the findings will be made available to various health experts that manage SCD patients especially haematologists.Trial Registration Number: This protocol is registered in PROSPERO; with registration number CRD42020213310.
Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation
Authors: Wang Jianbo , Li Weisheng , Zhou Naihui , Liu Jingliu , Zhang Shoumin , Li Xueli , Li Zhenlu , Yang Ziliang , Sun Miao , Li Min 
Published: November 2020

Abstract
Background: Familial progressive hyper- and hypopigmentation (FPHH, MIM 145250) is a rare hereditary skin disorder that is predominantly characterized by progressive, diffuse, partly blotchy hyperpigmented lesions intermingled with scattered hypopigmented spots, lentigines and sometimes Cafe-au-lait spots (CALs). Heterozygous mutations of the KIT ligand (KITLG, MIM 184745) gene are responsible for FPHH. To date, only eight KITLG mutations have been reported to be associated with FPHH, and no clear genotype-phenotype correlations have been established. This study aimed to identify the causative mutations in the KITLG gene in two Chinese FPHH patients.Methods: Direct sequencing of the coding regions of KITLG was performed. Pathogenicity prediction was performed using bioinformatics tools, including SIFT, Polyphen2, and SWISS-MODEL, and the results were further evaluated according to the 2015 American College of Medical Genetics and Genomics (ACMG) guidelines.Results: The novel mutation c.104A>T (p.Asn35Ile) and the recurrent mutation c.101C>T (p.Thr34Ile) in KITLG were identified. As shown using SIFT and Polyphen-2 software, both mutations identified in this study were predicted to be detrimental variations. Three-dimensional protein structure modeling indicated that the mutant KITLG proteins might affect the affinity of KITLG for its receptor, c-KIT. According to the 2015 ACMG guidelines, the novel mutation c.104A>T was ‘likely pathogenic’.Conclusions: To date, most of the identified KITLG mutations have been clustered within the conserved VTNNV motif (amino acids 33-37) in exon 2. The known mutations are only involved in 33V, 34T, 36N, and 37V but not 35N. We have now identified a novel mutation in KITLG, c.104A>T, that was first reported in FPHH within the conserved 35N motif. These results strengthen our understanding of FPHH and expand the mutational spectrum of the KITLG gene.
Economic burden of eating disorders in South Korea
Authors: Lee Sang Min , Hong Minha , Park Saengryeol , Kang Won Sub , Oh In-Hwan 
Published: November 2020

Abstract
BackgroundFew studies have investigated the epidemiology of eating disorders using national representative data. In this study, we investigated the prevalence and economic burden of eating disorders in South Korea.MethodsThe aim of this study was to estimate the medical expenditure of diagnosed eating disorders (ICD F50.x) in South Korea between 2010 and 2015. We also examined the economic costs of eating disorders, including the direct medical cost, direct non-medical costs, and indirect costs, in order to calculate the economic burden of such disorders.ResultsThe total prevalence of eating disorders in South Korea was 12.02 people (per 100 000) in 2010, and 13.28 in 2015. The cost of medical expenditures due to eating disorders increased from USD 1 229 724 in 2010 to USD 1 843 706 in 2015. The total economic cost of eating disorders was USD 5 455 626 in 2015. In 2015, the economic cost and prevalence of eating disorders was the highest in the 20–29 age group.ConclusionsThe results showed the eating disorders are insufficiently managed in the medical insurance system. Further research is therefore warranted to better understand the economic burdens of each type of eating disorder.
25-gauge vitrectomy with gas tamponade for rhegmatogenous retinal detachment: experienced vs. inexperienced surgeons
Authors: Pencak Martin , Veith Miroslav , Stranak Zbynek , Dite Jakub , Vranova Jana , Studeny Pavel 
Published: November 2020

Abstract
Introduction: To compare the results and complication rates of a 25-gauge pars plana vitrectomy (PPV) with gas tamponade for rhegmatogenous retinal detachment (RRD) between experienced and inexperienced surgeons.Materials and Methods: This is a retrospective comparative consecutive case series study of patients with uncomplicated RRD treated with 25g PPV with gas tamponade. Patients were divided into 2 groups: In experienced surgeon group (ESG) the procedure was performed by an experienced vitreoretinal surgeon and in inexperienced surgeon group (ISG) the procedure was performed by 2 inexperienced surgeons. Anatomical and functional results and complication rates were compared between the two groups.Results: 216 eyes were included in the study. In the ESG (106 eyes), the single operation success rate was 94.3%, and the final success rate was 100%. In the ISG (110 eyes), the single operation success rate was 93.6%, and the final success rate was 100.0%. The difference in single surgery success rate between groups was not statistically significant (P = 0.828). The mean postoperative BCVA improvement was 0.348 decimal in ESG and 0.405 decimal in ISG (P = 0.234). The difference in complication rates between groups was not significant.Conclusions: A 25g PPV with gas tamponade for treatment of RRD yields excellent anatomical results and improvement in BCVA. With good technique and use of modern vitrectomy machines and instruments, even inexperienced surgeons can achieve high single operation success rate, suggesting a short learning curve. The complication rate is comparable between experienced and inexperienced surgeons.
Epilepsy Surgery: A Paediatric Perspective
Authors: Bollard Lauren , Moore Emily , Paff Rebecca 
Published: November 2020

Abstract
250,000 people in Australia live with Epilepsy and more than 40% of those are children. Medication is a first line, effective treatment. However, not all patients have the desired outcome of seizure reduction or cessation. In fact, 1 in 3 do not gain full seizure control with medication alone.
Epilepsy surgery, while not a new concept of treatment for seizure management, has gained significant traction in the past decade and has become a particular focus of the Neurology Department at The Children’s Hospital, Westmead. This is evident by the expansion of the Neuroscience ward for the precise purpose of surgical intervention for the treatment of Epilepsy and other seizure conditions.
The paediatric patient journey to surgery is a complex and intricate one. It involves a collaborative approach of the multidisciplinary teams from diagnosis and beyond, whilst maintaining a high standard of holistic, family centred care. This paper aims to discuss this journey and the impact it has on the patients, families and the nurses involved.
La La importancia de la Diplomacia Científica y los Objetivos de Desarrollo Sostenible: Desafíos y Oportunidades
Authors: Echeverría King Luisa Fernanda , Widmaier Müller Claudia Natalie , Aquino Valle Karina Elizabeth 
Published: November 2020

El presente artículo pretende ahondar en los conceptos de diplomacia científica y su relación con los Objetivos de Desarrollo Sostenible, realizando especial hincapié en las oportunidades y desafíos de los mismos y exponiendo experiencias de América Latina. Frente al concepto de diplomacia científica, se desglosan los diferentes abordajes del mismo, así como las posibles acciones lideradas por los países para avanzar en intereses nacionales, transfronterizos y globales; igualmente de identificaron los actores de la diplomacia científica y sus roles. Se expresaron oportunidades para la implementación de la Agenda 2030, así como la importancia de la Cooperación Sur-Sur en este proceso. Se observa que si bien existen iniciativas exitosas, aún se encuentran muchos desaf por su partetido, co y social; la ientnjunta intereses a humanidadarrollo en los pa de alcanzar los planteamientos de la Agtendíos especialmente de cara a la financiación de la implementación de los ODS, su monitoreo y medición de indicadores. Asimismo, los países deben fortalecer sus esquemas de diplomacia científica con el fin de alcanzar de forma conjunta intereses en común.
Pengaruh Penilaian Kinerja dan Kecerdasan Emosional Berdasarkan Project Based Learning (PjBL) terhadap Hasil Belajar Matematika Siswa
Authors: Biantoro Nanly Ollyvia Putri Hestu , Kristanti Febriana , Mursyidah Himmatul 
Published: November 2020

<p>Penelitian ini bertujuan untuk mengetahui pengaruh penilaian kinerja siswa dan kecerdasan emosional siswa selama proses pembelajaran berdasarkan PjBL terhadap hasil belajar siswa. Penelitian ini menggunakan metode kuantitatif dengan desain penelitian korelasi. Sampel penelitian berada pada kelas VII-B SMP Muhammadiyah 10 Surabaya yang berjumlah 19 siswa. Instrumen yang digunakan yaitu soal tes materi perbandingan, lembar observasi kinerja siswa, dan angket kecerdasan emosional. Hasil penelitian menunjukan bahwa: (1) berdasarkan uji regresi linear sederhana variabel penilaian kinerja terhadap hasil belajar, diperoleh F hitung &gt; F tabel yaitu 4,632 &gt; 4,45 , artinya terdapat pengaruh penilaian kinerja terhadap hasil belajar sebesar 42,5%; (2) berdasarkan uji regresi linear sederhana variabel kecerdasan emosional terhadap hasil belajar, diperoleh F hitung &gt; F tabel yaitu 5,733 &gt; 4,45, artinya terdapat pengaruh kecerdasan emosional terhadap hasil belajar sebesar 33,6%;(3) berdasarkan uji regresi linear berganda variabel penilaian kinerja dan kecerdasan emosional terhadap hasil belajar, diperoleh F hitung &gt; F tabel yaitu 3,672 &gt; 3,59, artinya terdapat pengaruh penilaian kinerja dan kecerdasan emosional terhadap hasil belajar sebesar 60,7%.</p><p><strong>Kata kunci: </strong>kecerdasan emosional, penilaian kinerja, <em>Project Based Learning</em> (PjBL).</p>
iTRAQ-Based Proteomic Analysis of the Rat Pancreas Following Gastric Bypass Surgery
Authors: Xie Zhuolin , Bai Lu , Gao Xiang , Zhu Liyong , Zhu Shaihong , Li Weizheng , Li Pengzhou 
Published: November 2020

Aim:
There are many people with type 2 Diabetes Mellitus (T2DM) worldwide. Rouxen-
Y Gastric Bypass (RYGB) is an effective surgery for treating T2DM with beneficial effects on
β cell metabolism. However, the mechanism of how RYGB affects the pancreas, is not clear. We
focused on metabolic changes in the pancreas of rats following RYGBand to investigate complex
postoperative pancreatic metabolic reprogramming and to understand how RYGB improves islet
function.

Methods:
We performed RYGBonstreptozotocin-induced male T2DM rats. Then we measured indicators
such as weight, fasting GLU, etc. After 10 weeks, pancreatic tissues were removed to identify
and quantify differentially expressed proteins. Furthermore, functional analysis of these proteins
and their associated pathways was conducted by bioinformatics methods.

Results:
After surgery, 451 differentially expressed proteins associated with the mechanism
ofRYGB were identified. Protein levels of regenerating islet-derived protein 3 (Reg3A), cell division
cycle-associated protein 2 (CDCA2), and ADP-ribosylation factor 1 (Arf1) varied greatly, and
Arf1 may be a point target in diabetes.

Conclusion:
This research shows that RYGB could treat T2DM through changes in the pancreatic
proteins. It will give some new insight into the molecular mechanism behind the effect of RYGB.
Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis
Authors: Sherkatolabbasieh Hamidreza , Firouzi Majid , Shafizadeh Shiva , Amiri Iman 
Published: November 2020

Background:
The aim of this study is to evaluate the prevalence of group A beta-hemolytic pharyngitis by assessing the outcome of the culture and the resistance and sensitivity of group A beta hemolytic streptococcus to antibiotics.

Methods:
This cross-sectional study was conducted on 170 patients, aged 3-15 years, referred to the clinic with complaints
of sore throat. Patients’ history was collected and physical examination was performed and were score based on clinical
findings. Patients with other underlying pathologies and those taking antibiotics prior to the study were excluded from our
study. Antimicrobial susceptibility test was performed by disk diffusion method against cephalexin, cefazolin, erythromycin
and amoxicillin.

Results:
A total of 170 patients were reported with sore throat. Patients with positive culture results were 60% male and
40% female. Amoxicillin resistance was the greatest (5%) in the culture. All isolated bacteria were sensitive to amoxicillin,
cephalexin, cefazolin and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% specificity 61%
negative predictive value 94.8% and positive predictive value 20.3% for Group A beta-hemolytic streptococcal pharyngitis.

Conclusion:
The results showed the higher the clinical score, the greater the chance of positive throat culture.
Handelingen O.R. II - 2e afl.
Authors: Brysse Adrien 
Published: November 2020

F. Van Den Bemden : Le sher Gheeraerts sDievels steen. Note additionnelle.Albert Dutry : Statistique des piloris, perrons, pierres de justice et croix de marchés. Canton judiciaire de Lokeren.J. Vuylsteke : Het Gravenkasteel.
Handelingen O.R. III - 2e afl.
Authors: Admin Admin 
Published: November 2020

V. Fris : Ontleding van drie Vlaamsche Kronieken.J. Van Den Gheyn : Note sur un ancien livre d'Heures de l'hôpitalde Grammont.L. Stroobant : Le Rasphuys de Gand.A. Van Werveke : De Achter-Sikkel.
Da Delegação Legislativa
Authors: D. Landau Georges 
Published: November 2020

Nem ainda são decorridos dez anos da promulgação da ConstituiçãoBrasileira de 1946, que se cogita de reformá-la, visto não mais atender àsdinâmicas e mutáveis necessidades da evolução político-administrativa da Nação.
Convocou o Ministro de Estado dos Negócios da Justiça uma Comissãode Juristas, composta por cinco dentre os mais eminentes jurisconsultos patrícios,a fim de examinarem quais os principais pontos a serem abordados, noevento de uma revisão do texto constitucional. A referida Comissão ressaltoudesde logo que se impunha uma reforma do disposto no artigo 36, § 2.°, queveda taxativamente a delegação de atribuições, por um Poder da União aoutro. Desfarte, é assunto de palpitante atualidade o da delegação legislativa,e somos gratos ao Professor Caio Tácito por no-lo ter indicado como temapara a presente tese, na qual procuraremos, estribados nas opiniões dos maisconceituados estudiosos da matéria, demonstrar a flagrante ineficácia do referidodispositivo de nossa Lei Magna, e a urgência de sua substituição poroutro, que melhor se adapte à realidade nacional, pois, como já afirmavaCarlos Maximiliano .
Análise das Principais Teorias de Organização
Authors: Wahrlich Beatriz M.S. 
Published: November 2020

REFACIANDO o livro de E lton Mayo, O s Problemas Sociais de uma CivilizaçãoIndustrial, escreve W allace Daunham: Mayo estabeleceu novas bases para os métodosde estudo, para os meios de se obter, de cada trabalhador, melhorcompreensão de suas tarefas industriais e para as maneiras delhes aumentar a sensação de bem-estar no trabalho. Todos êssesdepoimentos envolveram reconhecimento do valor de grupos sociaise de equipes de trabalho, a par do trabalhador considerado individualmente.
Essas palavras se aplicam integralmente à escola de organização cujasidéias centrais vão ser aqui analisadas e que nasceram com as experiênciasfeitas em Hawthorne. Quando se publicaram os primeiros relatórios, ressaltaram-se o homem e as reações individuais, mas, gradualmente, passou-se adar,mais relêvo aos aspectos sociológicos do problema.
Application of Eddy Current Control in the Temperature Control Loop of the 3D Printing Process
Authors: Oskolkov A. A. , Bezukladnikov I. I. , Trushnikov D. N. 
Published: November 2020

Данная статья посвящена трехмерной печати по технологии FFF/FDM. Большинство существующих на рынке FDM 3D-принтеров используют косвенный резистивный метод нагрева сопла и стандартные термоэлектрические методы контроля температуры, что обусловливает высокую тепловую инерционность системы нагрева и невозможность обеспечения достаточной скорости и точности контроля температуры. Невозможность управления температурой сопла в процессе печати приводит к непостоянному качеству межслоевого спекания и неоднородности внутреннего объема напечатанных изделий. Для минимизации или устранения перечисленных недостатков предлагается индукционная система нагрева сопла минимальной тепловой массы. При этом для контроля температуры сопла предлагается резонансный (вихретоковый) метод. Высокие скоростные и мощностные характеристики предлагаемой системы делают актуальной задачу разработки контура управления температурой сопла.В модуле Simulink пакета Matlab была разработана имитационная модель контура управления температурой сопла. Определены передаточные функции индукционной системы нагрева сопла и цепи обратной связи.Были определены коэффициенты ПИД-регулятора и его период дискретизации, обеспечивающие нулевую статическую ошибку, величину перерегулирования в 1 %, что позволяет избежать перегрева материала в процессе экструзии. Достигнуто время выхода системы на установившийся режим в 1 с, что удовлетворяет требованиям скоростного нагрева и охлаждения сопла в процессе печати. Получены хорошие запасы устойчивости системы по фазе и амплитуде.Предложена реализация описанной системы и подход к ее применению в процессе трехмерной печати с использованием платы контроллера DuetWifi. Создан испытательный стенд и проведены эксперименты, подтверждающие высокие скоростные и точностные характеристики разработанного метода контроля и управления температурой сопла в процессе трехмерной печати.