bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mangiferin suppresses human metastatic osteosarcoma cell growth by down-regulating the expression of metalloproteinases-1/2 and parathyroid hormone receptor 1
Authors: Wen Jifeng , Qin Yong , Li Chao , Dai Xiankui , Wu Tong , Yin Wenzhe 
Published: January 2020

AbstractThe study evaluates the protective effect of mangiferin on osteosarcoma cell proliferation and metastasis. Saos-2 and U2OS cells were treated with mangiferin (25, 50, 75 and 100 µM) for 72 h. Mangiferin reduced the cell viability, invasion, and cell adhesion and migration rate. Matrix metalloproteinases-2/9 (MMP-2/9) mRNA expression was reduced significantly, while the levels of tissue inhibitors of metalloproteinases-1/2 (TIMP-1/2) were elevated in Saos-2 and U2OS cells. Mangiferin treatment significantly reduced parathyroid hormone receptor 1 (PTHR1) mRNA and protein expression by more than 0.5-fold in both osteosarcoma cells. In addition, the immunofluorescent analysis also showed decreased PTHR1 expression following treatment with mangiferin. In summary, we have demonstrated that treatment with mangiferin reduces cell viability, proliferation, invasion, adhesion and migration, and induces apoptosis of osteosarcoma cells. Therefore, treatment with mangiferin can be effective agent in inhibiting growth and inducing apoptosis in osteosarcoma cells. Our experimental results provide evidence for the therapeutic effect of mangiferin in osteosarcoma cells.
Transcriptomic profiling sheds light on the blue-light and red-light response of oyster mushroom (Pleurotus ostreatus)
Authors: Wang Huan , Tong Xidan , Tian Fenghua , Jia Chuanwen , Li Changtian , Li Yu 
Published: January 2020

AbstractBlue light is an important environmental factor that induces mushroom primordium differentiation and fruiting body development. Although blue-light treatment has been applied for the production of oyster mushroom (Pleurotus ostreatus), the blue-light response mechanisms of P. ostreatus still remain unclear. In the present study, we exposed the primordium of P. ostreatus to blue-light, red-light, and dark conditions for 7 days. Subsequently, comparative transcriptomics analysis of the stipe, pileus, and gill under the three light conditions was performed to reveal the gene expression response mechanism of P. ostreatus to blue light and red light. The results showed that blue light enhanced the growth and development of all the three organs of P. ostreatus, especially the pileus. In contrast, red light slightly (non-significantly) inhibited pileus growth. When compared with red-light and dark treatments, blue-light treatment significantly upregulated gene expression involved in glycolysis/gluconeogenesis, the pentose phosphate pathway and the peroxisome in the pileus, but not in the gill or stipe. Most of the glycolysis and pentose phosphate pathway genes were upregulated in the pileus by blue light. When compared with dark treatment, red-light treatment downregulated the expression of many respiration metabolism genes in the pileus. These results revealed that blue light enhanced the activation of glycolysis and the pentose phosphate pathway, whereas red light weakened glycolysis and pentose phosphate pathway activation. The conclusion can be drawn that blue light improved P. ostreatus fruiting body (particularly, the pileus) growth rate via enhancement of glycolysis and the pentose phosphate pathway.
Design and baseline data of a population-based metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation
Authors: Deng Yuxuan , Liang Yuanbo , Lin Sigeng , Wen Liang , Li Jin , Zhou Yue , Shen Meixiao , Zheng Jingwei , Feng Kemi , Sun Yanting , Robert Kwapong Willaim , Qu Jia , Lu Fan 
Published: January 2020

Abstract
Background
China is undergoing a massive transition toward an urban and industrial economy. These changes will restructure the demographics and economy which will eventually influence the future patterns of disease. The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood. Metabolomics is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier treatment. This article aims to describe the design, methodology and baseline data of the Yueqing Ocular Diseases Investigation (YODI), a developed county population-based study to determine the prevalence and primary causes of visual impairment; also with metabonomics analysis we aimed to identify, predict and suggest some preventive biomarkers that cause blindness.

Methods
A population-based, cross-sectional study. Randomized clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town, Yueqing county-level City. The interviews covered demographic, behavioral, ocular risk factors and mental health state. The ocular examination included visual acuity, autorefraction, intraocular pressure, anterior and posterior segment examinations, fundus photography, retinal tomography and angiography, and visual field testing. Anthropometric measurements included height and weight, waist and hip circumference, blood pressure, pulse rate, electrocardiogram, and abdominal ultrasound scan. A venous blood sample was collected for laboratory tests and metabonomics studies.

Results
Of the 5319 individuals recruited for the YODI, 4769 (89.7%) subjects were enrolled for analyses. The median age was 62.0 years, and 45.6% were male. The educational level of illiteracy or semi-illiteracy, primary, middle and high school or above was 29.8%, 45.5%, 20.1%, and 3.3%, respectively. Majority of the participants were female, younger, and less educated when compared with nonparticipants. The average body mass index and waist-hip ratios were 24.4 ± 3.4 kg/m2 and 0.9 ± 0.1 respectively. Blood sample collection reached a sample size of 1909 (479 from subjects with self-reported diabetes and 1430 from one-third of the 4290 subjects without self-reported diabetes).

Conclusions
The YODI provides population-based data with a high response rate (89.7%) on the prevalence and primary causes of major vision-impairing eye diseases in developed county areas in eastern China. Metabonomics analysis from YODI will provide further association of metabolic characteristics with the visual impairment eye diseases. The risk prediction model could be created and has the potential to be generalized to developed eastern areas in China for prevention.
Malware Guard Extension: abusing Intel SGX to conceal cache attacks
Authors: Schwarz Michael , Weiser Samuel , Gruss Daniel , Maurice Clémentine , Mangard Stefan 
Published: January 2020

AbstractIn modern computer systems, user processes are isolated from each other by the operating system and the hardware. Additionally, in a cloud scenario it is crucial that the hypervisor isolates tenants from other tenants that are co-located on the same physical machine. However, the hypervisor does not protect tenants against the cloud provider and thus, the supplied operating system and hardware. Intel SGX provides a mechanism that addresses this scenario. It aims at protecting user-level software from attacks from other processes, the operating system, and even physical attackers.In this paper, we demonstrate fine-grained software-based side-channel attacks from a malicious SGX enclave targeting co-located enclaves. Our attack is the first malware running on real SGX hardware, abusing SGX protection features to conceal itself. Furthermore, we demonstrate our attack both in a native environment and across multiple Docker containers. We perform a Prime+Probe cache side-channel attack on a co-located SGX enclave running an up-to-date RSA implementation that uses a constant-time multiplication primitive. The attack works, although in SGX enclaves, there are no timers, no large pages, no physical addresses, and no shared memory. In a semi-synchronous attack, we extract 96 % of an RSA private key from a single trace. We extract the full RSA private key in an automated attack from 11 traces within 5 min.
The impacts of bark harvesting on a population of Encephalartos transvenosus (Limpopo cycad), in Limpopo Province, South Africa
Authors: Bamigboye Samuel , M. PETER TSHISIKHAWE  
Published: January 2020

Cycads are the most threatened group of plants in the world and there are a wide range of ecological and anthropological forces responsible for the extinction risk of these taxa. South Africa is a global hotspot of cycad diversity and the country’s cycads are facing high extinction risk. In this study we sampled a population (n=34) of Encephalartos transvenosus Stapf & Burtt Davy, a cycad species endemic to Limpopo Province, South Africa. The population was located on the Soutpansberg mountain range in the Mutale local municipality. A survey was conducted to quantify the threats to the population. Forty-seven percent of the plants had been damaged by bark harvesting for traditional medicine, and the population showed a mortality rate of 9%. We recommend further studies at a range of Encephalartos transvenosus populations to provide a broader understanding of impacts of harvesting and population trends. We also recommend community based initiatives to enhance the protection of this species in the communities in which they are found.
Phenological behavior of Atlas cedar (Cedrus atlantica) forest to snow and precipitation variability in Boutaleb and Babors Mountains, Algeria
Authors: Missaoui Khaled , Gharzouli Rachid , Djellouli Yamna , Messner Frençois 
Published: January 2020

Abstract. Missaoui K, Gharzouli R, Djellouli Y, Messner F. 2020. Phenological behavior of Atlas cedar (Cedrus atlantica) forest to snow and precipitation variability in Boutaleb and Babors Mountains, Algeria. Biodiversitas 21: 239-245. Understanding the changes in snow and precipitation variability and how forest vegetation response to such changes is very important to maintain the long-term sustainability of the forest. However, relatively few studies have investigated this phenomenon in Algeria. This study was aimed to find out the response of Atlas cedar (Cedrus atlantica (Endl.) G.Manetti ex Carrière) forest in two areas (i.e Boutaleb and Babors Mountains) and their response to the precipitation and snow variability. The normalized difference vegetation index (NDVI) generated from satellite images of MODIS time series was used to survey the changes of the Atlas cedar throughout the study area well as dataset of monthly precipitation and snow of the province of Setif (northeast of Algeria) from 2000 to 2018. Descriptive analysis using Standarized Precipitation Index (SPI) showed the wetter years were more frequent in the past than in the last two decades. The NDVI values changes in both areas with high values were detected in Babors Mountains with statistically significant differences. Our findings showed important difference in Atlas cedar phenology from Boutaleb mountains to Babors Mountains which likely related to snow factor.
Modeling of absorption process of the water by the wood in two-dimensions
Authors: Amardo Nadia , Ouzidan Fatima , Atmani Rachid , Moubarak Faical , El Kouali M’hammed , Talbi Mohammed , El Brouzi Abdalhak 
Published: January 2020

Wood is a natural and highly anisotropic material. Therefore, mechanical characteristics of the material depend on the direction of wood. In this paper, we propose to describe the transfer of the water inside the wood in two dimensions by immersing the sample in liquid water. The potential which drives the transport of water through the wood is controlled by the diffusion transient process. A model based on a numerical finite difference method has been found to follow the absorption process of water above the fibers saturation point of two-dimensions.
Large Cameron Ulcer Bleed
Authors: Jabak Suha , Hashash Jana G. 
Published: January 2020

ABSTRACT
Cameron ulcers usually present with chronic obscure gastrointestinal bleeding. Few cases of life-threatening bleeding have been reported. We hereby present an elderly man who presented with upper gastrointestinal bleeding associated with hemodynamic instability because of a large cratered Cameron ulcer. This ulcer contained a large pseudoaneurysm, and endoscopic therapy was deemed unsafe. The patient had a recurrence of his bleeding, necessitating intervention by our interventional radiology colleagues and then surgical intervention for definitive therapy. This case is important because it familiarizes gastroenterologists with the endoscopic appearance of huge Cameron ulcers and therapeutic options to control hemostasis. It also stresses the importance of a multidisciplinary team approach to ensure the best outcomes for patients.
Trabalho e subjetividade na universidade: Por uma visão global e multifacetada dos processos de sofrimento e adoecimento
Authors: Silva Eduardo Pinto e 
Published: January 2020

O objetivo deste artigo é discutir as relações entre os processos de intensificação, extensificação e precarização do trabalho na universidade com o sofrimento e/ou adoecimento de professores, tutores, estudantes e técnico-administrativos. São apresentadas interlocuções de grupos de pesquisadores que discutem a relação entre trabalho e subjetividade. Destacamos, inicialmente, a intensificação do trabalho do professor na pós-graduação. Em seguida, apontamos os entrelaçamentos entre os referidos processos e suas relações com as múltiplas demandas da graduação e pós-graduação. Identificamos formas insidiosas e sorrateiras de sofrimento e adoecimento. Argumentamos ser necessário ampliar o olhar sobre o trabalho na universidade, de forma a considerar seus múltiplos agentes e sua dimensão global e multifacetada, sob a égide da degradação, desgaste e falta de sentido. Apontamos para situações nas quais distintas formas de sofrimento se desdobram em estresse, distúrbios de ansiedade ou depressão. Concluímos que tais desdobramentos podem provocar, especialmente nos estudantes, situações-limite de psychache, desalento e desesperança, de forma a implicar em tentativas ou atos suicidas que necessitam ser prevenidos e melhor investigados.
Intervening Variables and Savings Mobilization of Staff Owned Cooperative Societies in Nasarawa State Public Institutions (A Case Study of Naspoly Staff Multipurpose Cooperative Society Nasarawa State Nigeria)
Authors: Ibrahim A. Dauda , Musa Dauda I. 
Published: January 2020

This paper examined the intervening variables affecting the mobilization of savings of Staff owned Cooperative Societies in Nasarawa State Public Institutions and their effects on the savings mobilization. It was a survey research that focused on the Naspoly Staff Cooperative Society, Nasarawa State Polytechnic Lafia, Nasarawa State Nigeria. Questionnaire was administered to a randomly sampled 250 members from the 380 registered members as at December 2018, with the view to confirming that the following variables (family size, income level, number of children in school and market situation) affects savings mobilization of staff owned cooperative societies in public institutions in Nasarawa State. Data collected were analyzed using descriptive statistics and The Pearson Product Moment Correlation. Findings from results of the study showed that, the identified variables intervenes in savings activities of staff members, it actually hampered the society’s efforts in mobilizing savings. It conclude that, although these intervening variables are individualistic, they by extension affect the savings mobilization of the cooperative societies. In line with the findings of the study, it was recommended therefore, that With due consideration of the income factor which is a prime determinant of savings, government as a whole should consider improving staff take home and adopt measures that will ensure price control in the market. Government should ensure that the timing for review of staff salaries be reviewed two to three years looking at the rate of inflation in Nigeria.
THE INFLUENCE OF FINANCIAL MANAGEMENT FUNCTION TOWARDS COMPANY'S SKILLS AND VALUES IN INDONESIA’S CONSUMPTION GOODS INDUSTRY
Authors: Nurqamarani Adisthy Shabrina , Jonathan LCA. Robin , Militina Theresia 
Published: January 2020

This study aims to analyze and determine the effect of financial management functions in the form of investment decisions, funding decisions and dividend policies on profitability and corporate value in publicly listed companies within consumer goods industry in Indonesia during 2013-2015.
The population of the consumer goods industry sector that went public (www.idx.co.id) was 37 issuers and examined the financial statements of 32 issuers that distributed dividends in 2013-2015. This research is a quantitative study of causality among several variables. The data used are cross section data and secondary data types in the form of financial reports published on the Indonesia Stock Exchange, literature and research from other parties.
By using financial ratios related to financial management functions: investment decisions, funding decisions, dividend policy as an independent variable and profitability and firm value as the dependent variable, using path analysis assisted with the SPSS version 20, can be seen the magnitude of influence shown by the path coefficient on each path diagram of the causal relationship between the independent variables to the dependent variable.
The results showed that the functions of financial management have a significant effect on profitability. Investment decisions and profitability of companies have a positive and significant effect on firm value, while funding decisions and dividend policies have no significant effect on firm value. Proficiency does not have a significant effect in mediating the functions of financial management on firm value. But in terms of probability, it helped strengthen the influence of financial management functions on corporate value.
ANALYSIS OF REGIONAL ORIGINAL INCOME LEVELS IN REGIONAL FINANCIAL PERFORMANCE ON ECONOMIC GROWTH IN EAST JAVA PROVINCE
Authors: Yasin Muhammad yasin 
Published: January 2020

ABSTRACT
Economic growth is a process of changing a country's economic conditions on an ongoing basis towards better conditions for a certain period. Economic growth can also be interpreted as a process of increasing the production capacity of an economy that is realized in the form of an increase in national income. With a good Regional Financial Performance this is because the greater the Regional Original Revenues obtained from local taxes, regional levies, the results of the management of separated regional assets and other legal income and the smaller the loan and central assistance, the more independent the region. With the increasingly independent area, the economic growth in the area can experience an increase. This is because the region is able to manage economically, efficiently, and effectively as well as the lack of intervention by the central government. economic growth with This means that if the income of the region will also cause an increase in the achievement of economic growth. which is very flexible in terms of utilization causes the regions to be more flexible in planning the allocation of the budget for development activities in accordance with its economic agenda which includes the development of basic facilities and infrastructure that play a role in supporting optimal economic growth.
THE EFFECT OF MOTIVATION AND COMPENSATION ON EMPLOYEE PERFORMANCE WITH WORK SATISFACTION AS INTERVENING (CASE STUDY IN THE TECHNICAL DEPARTMENT OF PT SEMEN PADANG)
Authors: . Rusman Hidayat , Heryanto  
Published: January 2020

This study aims to determine the effect of motivation, compensation and job satisfaction on employee performance. The population in this study amounted to 285 employees and a sample of 167 respondents. This research was conducted in the Engineering Department, PT. Semen Padang by using primary data obtained through questionnaires. The data analysis technique used is Path Analysis technique and is operated through SPSS 16.0. The results showed that motivation had a significant effect on job satisfaction, compensation had a significant effect on job satisfaction, job satisfaction had a significant effect on employee performance, motivation and compensation directly had a significant effect on employee performance, motivation through job satisfaction had a significant effect on employee performance, compensation through satisfaction work on performance has no significant effect.
Excellence in Agri-Marketing through National Agricultural Market (NAM) for Sustainability of Indian Farming Sector
Authors: Arcot Purna Prasad , Rao Chandrasekhar 
Published: January 2020

National Agricultural Market (NAM), the most needed e-platform for the integration of agricultural markets across India is considered as an appropriate solution to overcome the challenges and problems faced by the present stakeholders of the Agri-marketing system. Related issues like states fragmentation into multiple market areas monitored by APMCs, different and numerous levy structures, multiple licenses requirement for trading across different mandis, interventions of high net worth bidders in price-fixing, inadequate infrastructural facilities in reaching mandis and non-usage of e-bidding technology, problems of information dissemination causing asymmetry, lack of transparency in price discovery, high market charges, movement controls between state to state, etc are to be addressed on priority basis in order to benefit the farmers and other stakeholders of agri-marketing industry. The need for the effective unified system across the country combining all agri-marketing platforms both at State and National level is the need of the day and has been well understood by our Prime Minister of India, Sri Narendra Modi and his team. The initiative is taken to have a sustainable environment through National Agricultural Market, which was launched on April 14, 2016. This enables a better price to farmers on their produce & improves the efficiency of the supply chain. Sustainable development is one which meets the needs of the present without compromising the ability of future generations to meet their needs.
In this paper, the authors have attempted to understand the National Agricultural Market’s success as a means to sustainability in agri-marketing directly and Indian economy growth indirectly. This paper will be partly based on the theoretical concept &somewhat empirical study that deals with the idea of National Agricultural Markets and its relevance in bringing sustainable development in agri-marketing. The theoretical part consists of a critical review of literature relevant to the concept of agricultural production, marketing and unified market system and concludes in an attempt at a more precise formulation of the idea. The empirical part of the study is based on questionnaires served to randomly select traders and farmers of Karnataka state where unified marketing system ReMS is implemented much earlier to NAM. The empirical part of the study is done to provide background information that makes it possible to discuss sustainable growth possibility in a practical context and should therefore not be seen as a direct attempt to confirm the theory. The research will enable a better understanding of NAM’s effort in achieving excellence in agri-marketing and sustainability of farming.