bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of Occlusal Plane in Growing Patients With Increased Vertical Dimension During Class II Correction by Using Cervical Headgear
Authors: Sambataro Sergio , Lorusso Paola , Caprioglio Alberto , Franchi Lorenzo , Cicciù Marco , Fastuca Rosamaria 
Published: December 2019

Abstract
This retrospective research aimed to highlight the changes of occlusal plane in Class II hyperdivergent subjects that received cervical headgear treatment and compared them to untreated controls in order to evaluate the occlusal changes that might be connected to a potential mandibular rotation.
The sample of this investigation was represented by 20 hyperdivergent Class II subjects (10 males, 10 females; mean age 8.54) corrected by using cervical headgear (treated group) and 21 Class II patients (11 males, 10 females; mean age 8.41) hyperdivergent who had no therapy (control group). Lateral head films were studied for all the patients before treatment (T1) and after therapy (T2) for both groups; cephalometric analysis was used in order to seek the modifications between time points and between groups.
Means and standard deviation have been computed for both groups. In order to confront the modification between the time points within the same group the Wilcoxon test was applied. The Mann–Whitney U test was applied to confront the dissimilarities between groups at T2.
As a result of the Class II correction by using the cervical headgear treatment the occlusal plane was lowered and flattened compared to T1 and to the control group; the upper molars showed extrusion to the palatal plane, there was a significant forward rotation of mandible and the vertical dimension was not significantly modified. Downward and backward displacement of the upper jaw occurred.
Gene drive and resilience through renewal with next generationCleave and Rescueselfish genetic elements
Authors: Oberhofer Georg , Ivy Tobin , Hay Bruce A 
Published: December 2019

AbstractGene drive-based strategies for modifying populations face the problem that genes encoding cargo and the drive mechanism are subject to separation, mutational inactivation, and loss of efficacy. Resilience, an ability to respond to these eventualities in ways that restore population modification with functional genes is needed for long-term success. Here we show that resilience can be achieved through cycles of population modification with “Cleave and Rescue”(ClvR) selfish genetic elements.ClvRcomprises a DNA sequence-modifying enzyme such as Cas9/gRNAs that disrupts endogenous versions of an essential gene, and a recoded version of the essential gene resistant to cleavage.ClvRspreads by creating conditions in which those lackingClvRdie because they lack functional versions of the essential gene. Cycles of modification can in principal be carried out if twoClvRelements targeting different essential genes are located at the same genomic position, and one of them,ClvRn+1, carries aRescuetransgene from an earlier element,ClvRn.ClvRn+1should spread within a population ofClvRn, while also bringing about a decrease in its frequency. To test this hypothesis we first show that multipleClvRs, each targeting a different essential gene, function when located at a common chromosomal position inDrosophila. We then show that when several of these also carry theRescuefrom a differentClvR, they spread to transgene fixation in populations fixed for the latter, and at its expense. Therefore, genetic modifications of populations can be overwritten with new content, providing an ongoing point of control.SignificanceGene drive can spread beneficial traits through populations, but will never be a one-shot project in which one genetic element provides all desired modifications, for an indefinitely long time. Here we show that gene drive mediated population modification inDrosophilacan be overwritten with new content while eliminating old, usingCleave and Rescue(ClvR) selfish genetic elements. The ability to carry out cycles of modification that create and then leave behind a minimal genetic footprint while entering and exiting a population provides important points of control. It makes possible the replacement of broken elements, upgrades with new elements that better carry out their tasks and/or provide new functions, all while promoting the removal of modifications no longer needed.
Reward produces learning of a consciously inaccessible feature
Authors: Dong Xue , Zhang Mingxia , Dong Bo , Jiang Yi , Bao Min 
Published: December 2019

AbstractReward has significant impacts on behavior and perception. Most past work in associative reward learning has used distinct visual cues to associate with different reward values. Thus, it remains unknown to what extent the learned associations depend on the consciousness. Here we resolved this issue by using an inter-ocular suppression paradigm with the monetary rewarding and non-rewarding cues identical to each other except for the eye-of-origin. Thus, the reward coding system cannot rely on the consciousness to select the reward-associated cue. Surprisingly, the targets in the rewarded eye broke into awareness faster than those in the non-rewarded eye. We further revealed that producing this effect required both attention and inter-ocular suppression. These findings suggest that the human’s reward coding system can produce two different types of reward-based learning. One is independent of the consciousness yet fairly consuming attentional resource. The other one results from volitional selections guided by top-down attention.
Symmetrically-dispersed spectroscopic single-molecule localization microscopy
Authors: Song K. , Zhang Y. , Brenner B. , Sun C. , Zhang H. F. 
Published: December 2019

AbstractSpectroscopic single-molecule localization microscopy (sSMLM) achieved simultaneously imaging and spectral analysis of single molecules for the first time. Current sSMLM fundamentally suffers from reduced photon budget because of dividing photons from individual stochastic emission into spatial and spectral channels. Therefore, both spatial localization and spectral analysis only use a portion of the total photons, leading to reduced precisions in both channels. To improve the spatial and spectral precisions, we present symmetrically-dispersed sSMLM or SDsSMLM to fully utilize all photons from individual stochastic emissions in both spatial and spectral channels. SDsSMLM achieved 10-nm spatial and 0.8-nm spectral precisions at a total photon budget of 1000. Comparing with existing sSMLM using a 1:3 splitting ratio between spatial and spectral channels, SDsSMLM improved the spatial and spectral precisions by 42% and 10%, respectively, under the same photon budget. We also demonstrated multi-color imaging in fixed cells and three-dimensional single-particle tracking using SDsSMLM.
Yeast Securin is trafficked through the endomembrane system to regulate cell cycle arrest during the DNA damage response
Authors: Lemos Brenda R. , Waterman David P. , Haber James E. 
Published: December 2019

AbstractThe yeast securin protein, Pds1, belongs to a class of highly conserved eukaryotic proteins that regulate the timing of chromatid segregation during mitosis by inhibiting separase, Esp1. During the metaphase to anaphase transition Pds1 is degraded by the ubiquitin-proteasome system in the nucleus, unleashing Esp1’s protease activity to cleave cohesin surrounding sister chromatids. In response to DNA damage Pds1 is phosphorylated and stabilized, stalling mitotic progression to preserve genomic integrity. In addition, during the DNA damage checkpoint response, securin and separase are partially localized in the vacuole. Here we genetically dissect the requirements for securin’s vacuolar localization and find that it is dependent on the Alkaline Phosphatase (ALP) endosomal transport pathway but not autophagy. Blocking retrograde traffic between the Golgi and the endoplasmic reticulum, by inhibiting COPI vesicle transport, drives Pds1 into the vacuole, whereas inhibiting antegrade transport by disrupting COPII-mediated traffic, results in the unexpected loss of Pds1 and the extinction of DNA damage-induced cell cycle arrest. We report that the induction of ER stress, either genetically or by treating cells with dithiothreitol, is sufficient to extinguish the DNA damage checkpoint, suggesting crosstalk between these two pathways. These data highlight new ways in which Pds1 and Esp1 are regulated during a DNA damage induced G2/M arrest and its requirement in the maintenance of the DNA damage checkpoint response.
Global broadcasting of local fractal fluctuations in a bodywide distributed system supports perception via effortful touch
Authors: Mangalam Madhur , Carver Nicole S. , Kelty-Stephen Damian G. 
Published: December 2019

AbstractA long history of research has pointed to the importance of fractal fluctuations in physiology, but so far, the physiological evidence of fractal fluctuations has been piecemeal and without clues to bodywide integration. What remains unknown is how fractal fluctuations might interact across the body and how those interactions might support the coordination of goal-directed behaviors. We demonstrate that a complex interplay of fractality in mechanical fluctuations across the body supports a more accurate perception of heaviness and length of occluded handheld objects via effortful touch in blindfolded individuals. For a given participant, the flow of fractal fluctuation through the body indexes the flow of perceptual information used to derive perceptual judgments. These patterns in the waxing and waning of fluctuations across disparate anatomical locations provide novel insights into how the high-dimensional flux of mechanotransduction is compressed into low-dimensional perceptual information specifying properties of hefted occluded objects.
Transcription-factor binding to replicated DNA
Authors: Bar-Ziv Raz , Brodsky Sagie , Chapal Michal , Barkai Naama 
Published: December 2019

SummaryGenome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage-imbalance between regions replicating at different S phase stages. Recently, we showed that these effects are integrated to maintain transcription homeostasis: replicated genes increase in dosage, but their expression remains stable due to replication-dependent epigenetic changes that suppress transcription. Here, we examined whether reduced transcription from replicated DNA results from limited accessibility to regulatory factors, by measuring the time-resolved binding of RNA polymerase II (RNAPII) and specific transcription factors (TFs) to DNA during S phase in budding yeast. We show that RNAPII binding-pattern is largely insensitive to DNA dosage, indicating limited binding to replicated DNA. By contrast, binding of three TFs (Reb1, Abf1 and Rap1) to DNA increased with the increasing DNA dosage. We conclude that the replication-specific chromatin environment remains accessible to regulatory factors, but suppresses RNA polymerase recruitment.
Narcissistic leadership and voice behavior: the role of job stress, traditionality, and trust in leaders
Authors: Yao Zhu , Zhang Xianchun , Liu Zhenxuan , Zhang Lili , Luo Jinlian 
Published: December 2019

PurposeThis study aims to investigate the impact of narcissistic leadership on employee voice behavior from the perspective of job stress, trust in leaders and traditionality in China.Design/methodology/approachThe authors conducted a survey on 437 employees to assess their narcissistic leadership in Time 1. In Time 2, they measured their job stress, trust in leaders and traditionality. In Time 3, they assessed the voice behavior of these employees.FindingsNarcissistic leadership correlates positively with employees’ job stress, which mediates between narcissistic leadership and employee voice behavior. Trust in leaders negatively moderates the correlation between job stress and employee voice behavior, as well as moderates the mediation effect of job stress on the correlation between narcissistic leadership and employee voice behavior. In addition, traditionality positively moderates the correlation between job stress and employee voice behavior, as well as moderates the mediation effect of job stress on the correlation between narcissistic leadership and employee voice behavior.Originality/valueThis study establishes the impact of narcissistic leadership on employee behavior from the perspective of job stress, trust in leaders and traditionality.
“Attitudes do matter”: generic competences in the selection of Business graduates
Authors: Charterina Jon , Pando-Garcia Julian , Periáñez-Cañadillas Iñaki 
Published: December 2019

Purpose
The purpose of this paper is to determine what competences are considered critical for team and human resources (HR) managers when selecting inexperienced Business graduates. Second, the authors aim to find out differences existing among businesses and organizations according to company size, and very particularly, the resources used with respect to the inexperienced graduate personnel selection practices.

Design/methodology/approach
To this end, the authors have performed an empirical study consisting of two qualitative data-gathering processes and a survey. First, the authors completed 12 in-depth interviews, followed by three world cafés with HR managers and consultants. Second, a survey was also conducted with 186 experienced Business graduates, team managers or middle-level staff.

Findings
The main results support the idea that generic competencies are the ones most appreciated in graduates. Attitudes are among the generic competencies considered most critical in inexperienced Business graduates. In particular, intra-personal, followed by inter-personal attitudes and values, were the most frequently cited and highly valued competencies. In contrast, most of the specific knowledge competences that are required for Business graduates are taken for granted. For its part, the authors found that excelling inexperienced graduates are those who show convincing proofs of holding attitudinal competences, signaled through some experience of international interchange programs, or pre-graduate internships in companies. Also, the authors found that HR managers and consultants show clear differences of preference for a set of competences or another depending on the size of the recruiting company. In particular, generic competences of knowledge, abilities, attitudes and values rate higher among small firms than larger ones.

Originality/value
Finally, the authors give recommendations for faculties and business schools headed to a more intensive development of generic competences, and the learning of skills on how to tailor curricula during studies and how to find jobs.
Determinants of international subsidiaries’ performances
Authors: Lo Fang-Yi , Tan Ricky 
Published: December 2019

PurposeOne important strategy Multinational Enterprises (MNEs) employ to compete in the global market is to engage in foreign investment, but firms must know how they can perform better in the host country market. International subsidiaries’ performances play a chief role for MNEs’ globalization strategy. The purpose of this paper is to construct multi-level research with parent-level data at the higher level and subsidiary-level data at the lower level.Design/methodology/approachThis study helps capture the rapid growing trend in emerging markets and uses a sample of Taiwanese enterprises and their subsidiaries in China. The data come from theTaiwan Economic Journaldatabase. Precisely, the authors obtain 711 Taiwanese MNEs and 4,458 of their subsidiaries in China.FindingsThis study finds among the parent company’s attributes that firm size, firm total performance, depth of internationalization and foreign shareholding have significant impacts on subsidiary performance, while within the subsidiary’s attributes, subsidiary size, subsidiary-owned capital and total investment fund significantly affect subsidiary performance.Originality/valueIn order to capture subsidiary performance, this study uses a multi-level analysis approach with the Hierarchical Linear Model statistic method to separate parent company attributes and subsidiary-owned attributes as two distinct levels. This method fills the gap in the literature by analyzing subsidiary performance and clarifying that foreign direct investment is a multi-level phenomenon that cannot be analyzed using a one-level analysis method.
Practising innovation in the healthcare ecosystem: the agency of third-party actors
Authors: Russo Spena Tiziana , Cristina Mele 
Published: December 2019

Purpose
Over recent years, few industries have seen such dramatic changes as the healthcare industry. The potential connectivity of digital technologies is completely transforming the healthcare ecosystem. This has resulted in companies increasingly investing in digital transformations to exploit data across channels, operations and patient outreach, by building on a practice approach and actor-network theory and being informed by service-dominant logic, this study aims to contribute by advancing the agential role of third-party actors to prompt innovation and shape service ecosystems.

Design/methodology/approach
This research is grounded in an epistemological contextualism. To gain situated knowledge and address the role of context in knowledge, understanding and meaning the authors adopted a qualitative methodology to study actors in their different contexts. The empirical research was based on case theory. The authors also took guidance from practice scholars about how to investigate actors’ practices. The unit of analysis moves from dyadic relationships to focus on practices across different networks of actors.

Findings
This study expands on the conceptualization of triad as proposed by Siltaloppi and Vargo (2017) by moving from the form of triadic relationships – brokerage, mediation and coalition – to the agency of e-health third-parties; and their practices to innovate in the healthcare ecosystem. This study focuses on the actors and the performativity of actions and grounding the conceptual view on an empirical base.

Practical implications
Third-party actors bring about innovative ways of doing business in the healthcare ecosystem. Their actions challenge the status quo and run counter to long-time practices. Third-parties support the complex set of interconnections between different healthcare actors for the provision of new service co-creation opportunities. Considering how these e-health third-parties performs has implications for health managers, patients and other actors.

Originality/value
This study focuses on the actors and the performativity of actions and grounding the conceptual view on an empirical base. The agency of third-party actors is their ability to act among others and to connect multiple social and material structures to boost innovation. They prompt innovation and shape service ecosystems by brokering, mediating and coalescing among a great variety of resources, practices and institutions.
The crimes of first-time offenders: same or different from the crimes of habitual criminals?
Authors: Walters Glenn D. 
Published: December 2019

PurposeThe purpose of this paper is to illustrate how first-time offenders and habitual criminals, while displaying wide differences in offense frequency, appear to follow a similar pattern in committing crime.Design/methodology/approachA conceptual approach is adopted in this paper.FindingsIt is argued that criminal thinking is the common denominator in both patterns, the difference being that habitual criminals have a higher resting level of proactive and reactive criminal thinking than first-time offenders. With an earlier age of onset, the habitual criminal may be more impulsive and reactive than first-time offenders, which partially explains why most low-rate offenders are not identified until adulthood.Practical implicationsBecause actual and perceived deterrents to crime correlate weakly, if at all, it is recommended that perceived environmental events and criminal thinking be the primary targets of prevention and intervention programs.Social implicationsEnvironmental stimuli, such as events that produce general strain, increase opportunities for crime, reinforce criminal associations, irritate the individual and interfere with the deterrent effect of perceived certainty, can both augment and interact with criminal thinking to increase the likelihood of a criminal act in both first-time offenders and habitual criminals.Originality/valueThe unique aspect of this paper is that it illustrates that certain features of crime and criminality are found across offending levels, whereas other features are more specific to a particular level.
Sanctification of work and turnover of teachers under insurgency
Authors: Vem Linus Jonathan , Mbasua Yakubu Ali , Davireng Makrop 
Published: December 2019

PurposeSanctification of work research is still a growing area among management and educational guild of researchers. The purpose of this paper is to explore the intervening role of career satisfaction and affective commitment in the relationship between sanctification and turnover intentions among teachers in a Boko Haram infested region of Nigeria.Design/methodology/approachThe authors adopted a cross-sectional survey design using 375 responses out of the 600 administered questionnaires to three states within the context of this study. The usable data were analyzed using SmartPLS version 3.2.7 to evaluate the hypothesized relationships.FindingsThe results reveal: negative but insignificant relationship between sanctification and turnover intention; career satisfaction and affective commitment mediate the relationship between sanctification of work and employee intention to leave.Originality/valueThe predictive role of sanctification was proven to be insignificant under unfriendly work environment, which is contrary to the literature on the role sanctification. The mediating role of career satisfaction and affective commitment between sanctification and turnover intention is relatively new. The two constructs constitute the mechanism through which the relationships are sustained; hence the hypotheses on the indirect relationships are established.