bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple Therapy With Budesonide/glycopyrrolate/formoterol Fumarate Used in Asthmatic Coexisting With Covid-19
Authors: Liang Yingjian , Chen Meizhu , Tan Cuiyan , Tu Changli , Huang Jin , Zheng Xiaobin , Liu Jing 
Published: June 2020

Abstract
Background: Awareness of the association between coronavirus disease 2019 (COVID-19) and airway diseases can effectively help in the treatment during the coronavirus pandemic. Case presentation: Herein, we present a COVID-19 case who confirmed to coexist with asthma. BGF was used as sequential medicine to systemic glucocorticoidsfor his persisted symptoms related to bronchospasms.Conclusion: Our case suggests patients with long-term airway diseases like asthma probably attribute to COVID-19 instead of primary diseases, which make it more difficult in the treatment.BGF is able to be an effective and convenient choiceas sequential medicine to systemic glucocorticoidsin some refractoryasthmatic patients complicated with COVID-19.
Regional inequality in the Janani Suraksha Yojana (JSY) coverage in India: A Geo-spatial Analysis
Authors: Mishra Prem Shankar , Kumar Pradeep , SRIVAST SHOBHIT 
Published: June 2020

Abstract
IntroductionAlthough India has made significant progress in Iinstitutional delivery after the implementation of National Rural Health Mission under which the Janani SurakshaYojna (JSY) is a sub-programme which played a vital role in the increase of institutional delivery in public facilties. However, a huge gap still, persists in terms of coverage and utilization of the JSY scheme, not only across socio-economic groups but also at district level in India. Therefore, this paper aims to provide an understanding of the JSY coverage at the district level in India. further, it tries to carve out the factors responsible for regional disparity of JSY coverage at district levels. MehtodsThe study used the fourth round of National Family Health Survey data and restricts sample size (n=148,145) to the women aged 15-49 years who gave recent birth in the institution during five years preceding the survey. Bivariate and multivariate regression analysis wasused to fulfill the study objectives. Additionally, Moran’s I statistics and bivariate Local Indicator for Spatial Association (LISA) maps were used to understand spatial dependence and clustering of JSY coverage. Ordianry least square, spatial lag and spatial error models were used to examine the correlates of JSY utilization.ResultsThe value of spatial-autocorrelation for JSY was 0.71 which depicts high dependence of the JSY coverage over districts of India. The overall coverage of JSY in India is 36.4% and it highly varied across different regions, districts, and even socioeconomic groups. The spatial error model depicts that if in a district the women with no schooling status increase by 10% than the benefits of JSY get increased by 2.3%. Similarly, if in a district the women from poor wealth quintile increases by 10% the benefits of JSY also increased by 4.6%. However coverage of JSY made greater imperative to understand it due to its clustering among distrcits of specific states only.ConclusionIt is well reflected in the EAGs states in terms of spatial-inequality in service coverage. There is aneed to universalize the JSY programme at a very individual level. And, it is required to revisit the policy strategy and the implementation plans at regional or district levels.
An Intersectional Analysis of the Composite Index of Anthropometric Failures in India
Authors: Ulahannan Sabu K , Basappa Yogish Channa , Joice Sangeetha V , Srini Prashanth N 
Published: June 2020

Abstract
Background: Nutritional inequality in India has been estimated typically using stunting, wasting and underweight separately which hide the overall magnitude and severity of undernutrition. We used the Composite Index of Anthropometric Failure (CIAF) that combines all three forms of anthropometric failures to assess the severity of undernutrition and identify the most vulnerable social groups and geographical hotspots.Method: CIAF was constructed using child anthropometric data from the fourth round of the National Family Health Survey (NFHS-4, 2015-16). We considered 24 intersecting sub-groups based on intersections across four main axes of inequality i.e., caste [Scheduled Tribe (ST), Scheduled Caste (SC) and Other], economic position (poor and non-poor), place of residence (rural and urban) and gender (male and female) (eg. ST-Poor-Rural-Female). Cross-tabulation and logistic regression were done to assess the odds of CIAF among intersecting groups and to identify the most vulnerable sub-groups. Concentration curve was plotted to visualise economic inequality in child undernutrition across caste categories. Choropleth maps were constructed and descriptive analysis of the district-level prevalence of CIAF was performed to identify the geographic clustering of undernutrition.Results: Overall 55.1% of children were undernourished by CIAF and 6.7% of children have simultaneous three anthropometric failure. In sub-group analysis, children from ST and SC caste have a higher risk of undernutrition irrespective of other axis of inequality. The typical urban advantage is reversed among the children from poor SC and other-caste in most sub-groups. Compared with CIAF, socio-economic inequality was amplified for simultaneous-three-failures among all caste categories. Socio-economic inequalities within caste are more for other caste and SC categories than with ST. Based on the analysis of the high prevalence in the co-occurrence of two or three failures, 111 districts from 12 of 29 states in India were identified across four geographic clusters.Conclusions: The study shows social and eco-geographical clustering of multi-dimensional anthropometric failures and indicates the need for focused nutritional interventions among SC and ST community in general and ST children from the poor households. Furthermore, governance interventions that target entire regions across districts and states combined with decentralised planning are needed.
Afebrile Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection have a Longer Viral Positivity Duration: A Retrospective Analysis of 125 Patients
Authors: Ding Rui , Zhao Rugang , Xie Wen , Fan Ying , Liu Ligai , Cao Ying , Cheng Cheng , Wang JingJing , Wang Qi , Wang Yanbin , Zhang Ting , LI Minghui 
Published: June 2020

Abstract
Background: A pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is on-going. Clinical characters of afebrile cases infected with SARS-CoV-2 remain poorly understood and informations are limited on the duration of SARS-CoV-2 viral positivity.Methods: We performed a single-center retrospective study of 125 patients with SARS-CoV-2 infection in Beijing Ditan Hospital, Capital Medical University from January 26 to March 15, 2020. Differences were compared among patients with/without fever. Risk factors for the duration of SARS-CoV-2 viral positivity were evaluated.Results: A total of 125 patients with positive SARS-CoV-2 test were enrolled, including 38 afebrile patients and 87 febrile patients. On admission, a total of 35 (28%) patients had leukopenia, 41 (32.8%) had lymphopenia and 6 (4.8%) had thrombocytopenia. 73 patients (58.4%) had a loss of T lymphocytes and 96 patients (76.8%) had decreased CD4+T lymphocytes. Compared with febrile cases, afebrile patients had a significantly higher white blood cell count (P = 0.001), total lymphocytes (P < 0.001), platelet count (P < 0.001), T lymphocytes (P = 0.013) and CD8+ T lymphocytes (P = 0.002). The median SARS-CoV-2 viral positivity duration of these 125 patients was 14 days (IQR, 10-30 days) and for febrile and afebrile group were 12 days (IQR, 9-23 days) and 23 days (IQR, 11-30 days) respectively. Multivariate Cox regression results showed that the fever [hazard ratio (HR) = 0.497, P = 0.006], young age (HR = 0.965, P = 0.018), and higher count of platelet (HR = 4.555, P = 0.034) were the predominant risk factor for the SARS-CoV-2 viral positivity duration.Conclusion: The SARS-CoV-2 virial positivity duration of the afebrile group was significantly longer than that in the febrile group. Fever, young age and a higher count of platelet were the independent protective factors for a shorter SARS-CoV-2 RNA positivity duration.
Toward Understanding Curcumin Delivery by Trimethyl Chitosan -polyethylene Glycol: Optimization Ofpolymer Concentration and Chain Length by Molecular Dynamics
Authors: Sohrabi Somayeh , Khedri Mohammad , Maleki Reza , Moraveji Mostafa , Ghasemy Ebrahim 
Published: June 2020

Abstract
The second main cause of death in the world and one of the major public health problems is cancer. Curcumin is anatural bioactive substance with good anti-cancerous effect.However, due to thelow cellular uptake of curcumin anti-cancer drug, it is vital to exploit a noble formulation, which can contribute to a decrease in its hydrophobicity and enables theefficient therapeutic effect of curcumin. Biocompatibility and hydrophilicity of the polyethylene glycol cause itto be one of the most attractive drug carriers. Chitosan is also of great importance, consideringits biocompatibility,and is used along with thedrug-carrying polymers. In this study, for the first time, a combination oftrimethyl chitosan and polyethylene glycol was employedto deliver curcumin.Herein, hydrophilicity, stability, and energy analysis of the systems have been investigated, from which it was found thatthe 60/40 is the optimum ratio concentration ofchitosan to polyethylene glycol for Curcumin delivery. Another characteristic property of the hybrid drug delivery system was the PEG chain length, with its least magnitude being the optimal value. Results of the present molecular study give a practicalinsight into the curcumin drug delivery system and propose a novel hybrid carrier for efficient curcumin delivery, which can be further exploited to develop novel nanomedicine systems.
Evaluation of Metadata Describing Topographic Maps in a National Library
Authors: Kuzma Marta , Moscicka Albina 
Published: June 2020

Abstract
The aim of our research is topographic maps metadata to evaluate their usability of specific users’ needs, using topographic maps because they are typically among the most heavily used for research and other purposes.To assess metadata for the purposes of evaluating the usability of topographic maps, a two-stage procedure was used. It covers the evaluation of topographic maps metadata, followed by their assessment in terms of whether maps found on their basis might be useful in our research.The research was carried out on 35,092 topographic maps issued in the years 1608-2017, in scales ranging from 1:10,000 to 1:500,000 from the National Library of Poland. These maps mainly cover the current territories of Poland, Belarus, Germany, Ukraine, Czech Republic, Lithuania, and Russia.The conducted analysis of topographic maps in the National Library of Poland revealed that the collected data are very interesting and match the users’ needs.
The Prevalence Rate of Sexual Violence in Worldwide Countries: A Trend Analysis
Authors: Borumandnia Nasrin , Khadembashi Naghmeh , Tabatabaei Mohammad , Majd Hamid Alavi 
Published: June 2020

Abstract
Background: The purpose of the present study is to showcase an image of Sexual Violence (SV) temporal trends through exploring differences in the prevalence rates during 1990-2017 across 195 countries and territories.Methods: The SV prevalence data for both sexes reported by the Global Burden of Disease database during 1990-2017 for 195 countries were analyzed via Growth Mixture models (GMM). Results: In worldwide, the SV prevalence rate was higher in women than in men and decreased in both genders over time. The declining trend in male SV prevalence is visible in countries with both high to very high and also moderate to low Human Development Index (HDI), but the prevalence of SV against women in countries with moderate to low HDI has increased. Findings of GMM identified six classes of SV prevalence trajectories. The highest decrease in the prevalence of SV against men was in Bermuda and the highest increase was observed in Equatorial Guinea and Luxembourg. The aforementioned countries had distinct trends from others, while other countries had very slow declining trends. SV against women in China, North Korea, and Taiwan has increased the most among countries in the world. Bermuda, Guyana, Mexico, Nigeria and Saint Lucia have witnessed the largest declines in recent decades and Angola, the Democratic Republic of Congo, and Equatorial Guinea have been ranked next. The observed trend in terms of SV prevalence rate against women in other countries has been mostly decreasing.Conclusion: Given the high economic and social burden that SV has on victims and society, the rate of SV in most countries does not seem to have dropped remarkably and requires special attention from relevant policy makers. In addition, the rate of SV prevalence is highly heterogeneous among world countries which may be due to the definitions used, tools used, and more importantly, the culture, norms.
Analysis of Six Bone-derived Factors in Plasma and Csf of Chinese Patients With Parkinson's Disease
Authors: Chen Xiang , Lin Yuwan , Chen Chaojun , Guo Wenyuan , Zhou Miaomiao , Qiu Jiewen , Zhang Zhiling , Mo Mingshu , Ding Liuyan , Ye Panghai , Wu Yijuan , Zhu Xiaoqin , Ren Yi , Yang Xingling , Zhang Xiaokang , Wu Zhuohua , Xu Pingyi 
Published: June 2020

Abstract
BackgroundParkinson's disease (PD) has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progress.ObjectivesTo detect the six bone-derived factors in plasma and CSFof patient swith PD and evaluate their correlations with CRP level, motor impairment and HY stage of the disease.MethodsWe included 250 PD patients and 250 controls. Levels of OCN, OPN,OPG, SO, BMP2 andDKK-1 in Plasma and CSF were measured by custom protein antibody arrays.Data were analyzed using Mann-Whitney U-testand Spearman’s rank correlation.ResultsPlasma levels of OCN and OPN were correlated with CRP level and HY stage and motor impairment of PD.Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD.ConclusionsOCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talks between the two factors and PD.
Nitrogen Addition Did Not Alter the Relationships Between the Leaf and Root Traits of Machilus Pauhoi seedlings
Authors: Zou Yuxing , Li Baoyin , Yu Hua , Chen Xiaoping , Deng Xingyu , Cheng Dongliang , Zhong Quanlin 
Published: June 2020

Abstract
Leaves and roots are important resource acquisition organs of seedlings and both are sensitive to the environment. However, it is currently unclear whether leaf and root traits have a similar response model to nitrogen (N) deposition. Furthermore, the relationships between the responses of leaf and root traits to N deposition are still unknown.Exogenous nitrogen input experiments were conducted to simulate the effects of nitrogen deposition in Shunchang County, south of China. We measured the biomass, morphological characteristics, and nutrient concentrations (total of 12 functional traits of leaves and roots) of Machilus pauhoi seedlings. The responses of leaf and root traits to N addition were analyzed. In addition, the relationships between paired leaf and root traits were analyzed.We found that the responses of the leaves and roots to short-term nitrogen deposition were not consistent. The specific leaf area (SLA) (specific root length, SRL), tissue density (TD), carbon (C) content, N content, C/N, and N/phosphorus (P) of the leaf and root did not appear to respond to N addition. However, the biomass, P content, and C/P of the leaf and root markedly responded to N addition. The nutrient concentrations of the leaf and root were correlated, while the phenotypic traits were not. Furthermore, short-term N addition did not alter the relationship between the leaves and roots.Our results show that, in the context of global change of nitrogen deposition, the correlation between the leaves and roots of a plant has a certain tolerance for nitrogen deposition, which is of great significance for the efficient cultivation of quality seedlings and understanding how terrestrial forest ecosystems respond to nitrogen deposition.
Lengthening of Achilles Tendon from the Percutaneous Tenotomy Procedure in Ponseti’s Method
Authors: Lin Yen Chang , Chang Wei Ning , Lai Yu Cheng 
Published: June 2020

Abstract
Background Talipes equinovarus is one of the common congenital disease of foot deformity of newborn. Initial treatment is often with the Ponseti method. Studies have demonstrated that radiographic measurements can be made with clubfoot. The purposes of this study were to document the amount of Achilles tendon lengthening obtained from PAT in Ponseti’s method and to analyze the factors that might impact on the amount of equinus correction. Methods This is a retrospective study carried out from 2002 to 2006. Sixteen feet of twelve children that received percutaneous Achilles tendon tenotomy (PAT) for the treatment of congenital clubfoot were included. Assessments before and after treatment were performed using Dimeglio system. The foot length from toe to heel at the time of PAT, the pre- and post-PAT ankle dorsiflexion and post-casting lateral view of foot were obtained. The Pearson correlation coefficient was used to establish relationships between pre-, post-PATT and post-casting Tibio-calcaneal angle (TCA) and Achilles tendon length(ATL).Results The TCA before, after PATT, and after casting were -9.3, 27.4 and 18.4degrees. The ATL before, after PATT, and after casting were 22.7, 31.3, and 28.3mm. The overall lengthening of Achilles tendon was 5.7% of the foot length. The pre-PATT TCA was correlated with post-PATT and post-casting TCA. The pre-PATT ATL was correlated with post-PATT ATL and post-casting ATL.Conclusion Post-PAT correction effect is negatively correlated with the pre-PAT severity of equinus. The comparison between post-PAT and post-casting TCA could be used to check the quality of casting in the Ponseti method.Level of Evidence: level IV
Magnetic Solid-Phase Extraction and in Situ Derivatization for Determining Phytohormones and in Oilseeds by Ultra-Performance Liquid Chromatography-tandem Mass Spectrometry
Authors: Luo Zhoufei , Xu Mengwei , Wang Ruozhong , Liu Xiubing , Xiao Langtao 
Published: June 2020

Abstract
Background: Phytohormones are a group of naturally occurring signaling molecules which influence physiological processes of oil crops. Simultaneous determination of multiple phytohormones in oilseeds is still a challenge due to their trace concentrations, species diversity, and lipid interference. Therefore, a simple and selective method for the simultaneous determination of multiple phytohormones in oilseeds is urgently needed.Results: In this study, the Fe3O4@Ti3C2@β-CD nanoparticles were successfully synthesized and used for the first time as an adsorbent for the magnetic dispersive solid-phase extraction of phytohormones from oilseeds. The magnetic dispersive solid-phase extraction and in situ derivation by the addition of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) were ingeniously combined. This efficient pre-treatment method integrated the extraction, purification, and derivatization processes into one single step. Several parameters affecting the efficiency of extraction and derivatization were evaluated. Under the optimized analysis conditions, satisfactory methodological performance was achieved. High linearities (R2 > 0.9928) at three spiked levels, as well as the low matrix effect (ranged from ­16.63 % to 17.06 %) and limits of detection (0.89-13.62 pg/mL) were also obtained. The intra and inter-day relative standard deviations (RSDs) were less than 13.7 % and 11.6 %, respectively. The recoveries were ranged from 80.4 % to 115.1 %. This method was successfully employed for analyzing 12 phytohormones in different oilseeds samples.Conclusion: A simple and sensitive method based on the magnetic solid phase extraction integrated with in situ derivations for the profiling of 12 phytohormones, including 9 gibberellins (GAs), indole-3-acetic acid (IAA), abscisic acid (ABA), and jasmonic acid (JA) in a single rapeseed seed was developed by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
LncRNA DLGAP1-AS2 SiRNA Silencing Inhibits Hepatocellular Carcinoma Cell Migration and Invasion by Up-regulating MiR-154-5p Through Methylation
Authors: Chen Kai , Zhang Zhuqing , Yu Aijun , Li Jian , Liu Jinlong , Zhang Xuejun 
Published: June 2020

Abstract
Background:DLGAP1-AS2 has been characterized as an oncogenic lncRNA in glioma. This study was performed to explore the role of DLGAP1-AS2 in hepatocellular carcinoma (HCC). Methods:Expression of DLGAP1-AS2 and miR-154-5p in paired HCC and non-tumor tissues from 62 HCC patients was determined by RT-qPCR. The 62 HCC patients were followed up for 5 years to analyze the prognostic value of DLGAP1-AS2 for HCC. DLGAP1-AS2 siRNA silencing and miR-154-5p overexpression was achieved in HCC cells to study the relationship between them. Methylation of miR-154-5p was analyzed by methylation-specific PCR. Cell proliferation was analyzed by CCK-8 assay.Results: DLGAP1-AS2 was upregulated in HCC and predicted poor survival. MiR-154-5p was downregulated in HCC and inversely correlated with DLGAP1-AS2. In HCC cells, DLGAP1-AS2 siRNA silencing resulted in the upregulation of miR-154-5p and decreased methylation of miR-154-5p gene. Transwell assay showed that, DLGAP1-AS2 siRNA silencing and miR-154-5p overexpression inhibited cell invasion and migration, and the combination of LGAP1-AS2 siRNA silencing and miR-154-5p overexpression showed stronger effects.Conclusion: DLGAP1-AS2 siRNA silencing may inhibit HCC cell migration and invasion by up-regulating miR-154-5p through methylation.