bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke
Authors: Zuo Lei , Zhang Lin , Zu Juan , Wang Zan , Han Bing , Chen Biling , Cheng Mengjing , Ju Minzi , Li Mingyue , Shu Guofang , Yuan Mengqin , Jiang Wei , Chen Xufeng , Yan Fuling , Zhang Zhijun , Yao Honghong 
Published: November 2019

Background and Purpose—
Circular RNAs (CircRNAs) show promise as stroke biomarkers because of their participation in various pathophysiological processes associated with acute ischemic stroke (AIS) and stability in peripheral blood.

Methods—
A circRNA microarray was used to identify differentially expressed circulating circRNAs in a discovery cohort (3 versus 3). Validation (36 versus 36) and replication (200 versus 100) were performed in independent cohorts by quantitative polymerase chain reaction. Platelets, lymphocytes, and granulocytes were separated from blood to examine the origins of circRNAs.

Results—
There were 3 upregulated circRNAs in Chinese population–based AIS patients compared with healthy controls. The combination of 3 circRNAs resulted in an area under the curve of 0.875, corresponding to a specificity of 91% and a sensitivity of 71.5% in AIS diagnosis. Furthermore, the combination of change rate in 3 circRNAs within the first 7 days of treatment showed an area under the curve of 0.960 in predicting stroke outcome. There was significant increase in lymphocytes and granulocytes for circPDS5B (circular RNA PDS5B) and only in granulocytes for circCDC14A (circular RNA CDC14A) in AIS patients compared with healthy controls.

Conclusions—
Three circRNAs could serve as biomarkers for AIS diagnosis and prediction of stroke outcomes. The elevated levels of circPDS5B and circCDC14A after stroke might be because of increased levels in lymphocytes and granulocytes.
Metaphysics, Elemental Transformation, Medicine
Authors: Bertolacci Amos 
Published: November 2019

Abstract
The present article brings to the scholarly attention the Avicennian manuscript San Lorenzo de El Escorial (Madrid), Real Biblioteca del Monasterio de San Lorenzo de El Escorial, 621, by conveying a basic description of its codicological features and by locating it in the wider context of the connection metaphysics-medicine that the transmission of Avicenna’s magnum opus Kitāb al-Šifāʾ (Book of the Cure/Healing) displays. The manuscript at stake is the only extant, though incomplete, codex of the Ilāhiyyāt (Science of Divine Things) of Avicenna’s Šifāʾ presently known in the Iberian peninsula (Spain and Portugal), and one of the few codices of the Šifāʾ housed there. In its present state, it cumulates metaphysics and medicine, since it joins some excerpts of the Ilāhiyyāt with fragments of the commentaries on Avicenna’s Al-Qānūn fī l-ṭibb (Canon of Medicine) by Ibn al-Nafīs al-Qurašī (d. 687 H/1288) and by Quṭb al-Dīn al-Šīrāzī (634–719 H/1236–1311). The part of the commentary on Avicenna’s Canon by Ibn al-Nafīs al-Qurašī preserved in this manuscript contains a revealing critical quotation of a medical tenet which Avicenna discusses in the Šifāʾ; this criticism very likely represents an instance of the ‘rectification’ of Avicenna’s philosophical encyclopedia of which Ibn al-Nafīs is credited in historical sources. The example of the revision of Avicenna’s philosophy by Ibn al-Nafīs analyzed on the basis of this manuscript makes clear that physicians in the XIII century did not limit their familiarity with Avicenna’s works to the Canon of Medicine and the other medical works of Avicenna, but adopted some kind of all-encompassing approach to Avicenna’s oeuvre, which did not eschewed tackling critically also the Šifāʾ on the basis of a profound and extensive knowledge of the Šayḫ al-raʾīs’s philosophical masterpiece.
Comparison of Statistical and Dynamic Downscaling Techniques in Generating High-Resolution Temperatures in China from CMIP5 GCMs
Authors: Zhang Lei , Xu YinLong , Meng ChunChun , Li XinHua , Liu Huan , Wang ChangGui 
Published: November 2019

AbstractIn aiming for better access to climate change information and for providing climate service, it is important to obtain reliable high-resolution temperature simulations. Systematic comparisons are still deficient between statistical and dynamic downscaling techniques because of their inherent unavoidable uncertainties. In this paper, 20 global climate models (GCMs) and one regional climate model [Providing Regional Climates to Impact Studies (PRECIS)] are employed to evaluate their capabilities in reproducing average trends of mean temperature (Tm), maximum temperature (Tmax), minimum temperature (Tmin), diurnal temperature range (DTR), and extreme events represented by frost days (FD) and heat-wave days (HD) across China. It is shown generally that bias of temperatures from GCMs relative to observations is over ±1°C across more than one-half of mainland China. PRECIS demonstrates better representation of temperatures (except for HD) relative to GCMs. There is relatively better performance in Huanghuai, Jianghuai, Jianghan, south Yangzi River, and South China, whereas estimation is not as good in Xinjiang, the eastern part of northwest China, and the Tibetan Plateau. Bias-correction spatial disaggregation is used to downscale GCMs outputs, and bias correction is applied for PRECIS outputs, which demonstrate better improvement to a bias within ±0.2°C for Tm, Tmax, Tmin, and DTR and ±2 days for FD and HD. Furthermore, such improvement is also verified by the evidence of increased spatial correlation coefficient and symmetrical uncertainty, decreased root-mean-square error, and lower standard deviation for reproductions. It is seen from comprehensive ranking metrics that different downscaled models show the most improvement across different climatic regions, implying that optional ensembles of models should be adopted to provide sufficient high-quality climate information.
Impact of Multidecadal Variability in Atlantic SST on Winter Atmospheric Blocking
Authors: Kwon Young-Oh , Seo Hyodae , Ummenhofer Caroline C. , Joyce Terrence M. 
Published: November 2019

AbstractRecent studies have suggested that coherent multidecadal variability exists between North Atlantic atmospheric blocking frequency and the Atlantic multidecadal variability (AMV). However, the role of AMV in modulating blocking variability on multidecadal times scales is not fully understood. This study examines this issue primarily using the NOAA Twentieth Century Reanalysis for 1901–2010. The second mode of the empirical orthogonal function for winter (December–March) atmospheric blocking variability in the North Atlantic exhibits oppositely signed anomalies of blocking frequency over Greenland and the Azores. Furthermore, its principal component time series shows a dominant multidecadal variability lagging AMV by several years. Composite analyses show that this lag is due to the slow evolution of the AMV sea surface temperature (SST) anomalies, which is likely driven by the ocean circulation. Following the warm phase of AMV, the warm SST anomalies emerge in the western subpolar gyre over 3–7 years. The ocean–atmosphere interaction over these 3–7-yr periods is characterized by the damping of the warm SST anomalies by the surface heat flux anomalies, which in turn reduce the overall meridional gradient of the air temperature and thus weaken the meridional transient eddy heat flux in the lower troposphere. The anomalous transient eddy forcing then shifts the eddy-driven jet equatorward, resulting in enhanced Rossby wave breaking and blocking on the northern flank of the jet over Greenland. The opposite is true with the AMV cold phases but with much shorter lags, as the evolution of SST anomalies differs in the warm and cold phases.
Accuracy and precision of a CT method for assessing migration in shoulder arthroplasty: an experimental study
Authors: Brodén Cyrus , Giles Joshua W , Popat Ravi , Fetherston Shirley , Olivecrona Henrik , Sandberg Olof , Maguire Gerald Q , Noz Marilyn E , Sköldenberg Olof , Emery Roger 
Published: November 2019

Background Radiostereometric analysis (RSA) is the gold standard to measure early implant migration which is a predictive factor for implant survival. Purpose To validate an alternative computed tomography (CT) technique to measure implant migration in shoulder arthroplasty. Material and Methods A cadaver proximal humerus and a scapula, which had tantalum beads incorporated within them, were prepared to accept a short-stemmed humeral component and a two-pegged glenoid component of a commercial total shoulder arthroplasty (TSA) system. A five degree of freedom micrometer and goniometer equipped rig was used to translate and rotate the implant components relative to the respective bone to predetermined positions. Double CT examinations were performed for each position and CT motion analysis software (CTMA) was used to assess these movements. The accuracy and precision of the software was estimated using the rig’s micrometers and goniometers as the gold standard. The technique’s effective dose was also assessed. Results The accuracy was in the range of 0.07–0.23 mm in translation and 0.22–0.71° in rotation. The precision was in the range of 0.08–0.15 mm in translation and 0.23–0.54° in rotation. The mean effective dose for the CT scans was calculated to be 0.27 mSv. Conclusion In this experimental setting, accuracy, precision, and effective dose of the CTMA technique were found to be comparable to that of RSA. Therefore, we believe clinical studies are warranted to determine if CTMA is a suitable alternative to traditional RSA for migration measurements in TSA.
Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy
Authors: Jung Hye Na , Kim Sung Mok , Lee Jeong Hyun , Kim Yiseul , Lee Sang-Chol , Jeon Eun-Seok , Yong Hwan Seok , Choe Yeon Hyeon 
Published: November 2019

Background Administration of gadolinium-contrast can cause problems in cardiac amyloidosis (CA) patients with impaired renal function. Purpose To compare patterns of cardiovascular magnetic resonance tissue tracking (CMR-TT) for CA and hypertrophic cardiomyopathy (HCM) and to assess the feasibility of CMR-TT to distinguish between these diseases without administration of gadolinium-contrast. Material and Methods Included were 54 patients with biopsy-proven CA, 40 patients with HCM, and 30 healthy people. We calculated strain ratio of apex to base (SRAB) in the left ventricle (LV) using radial (R), circumferential (C), and longitudinal (L) strain from CMR-TT. The LV ejection fraction (LVEF) and the ratio of septal to posterior wall at basal level were also calculated. Late gadolinium enhancement (LGE) image analysis was performed for differential diagnosis. Area under the receiver operating characteristic curve (AUC) comparisons were used. Results All SRAB values were significantly different between CA and HCM (all P <  0.001). AUC values for parameters were 0.806 for LVEF, 0.815 for ratio of wall thickness, 0.944 for the LGE pattern, 0.898 for SRABR, 0.880 for SRABC, and 0.805 for SRABL. AUCs for the LGE pattern were significantly higher than for LVEF, ratio of wall thickness and SRABL (all P <  0.008). No significant differences were seen between AUCs for the LGE pattern, SRABR, and SRABC (all P >  0.109). Conclusion SRABR and SRABC were reliable parameters for distinguishing between CA and HCM.
Relapsed refractory metastatic squamous cell cancer of anal canal in a patient with retroviral infection responding to cetuximab
Authors: Lerner Jaren , Michel Miguel , Dasanu Constantin A 
Published: November 2019

Introduction Conventional first-line therapy for squamous cell carcinoma of anal canal is definitive chemoradiotherapy with a curative intent. Due to the efficacy of treatment for locoregional disease and rarity of metastatic anal carcinoma, clinical trial data for treatment of metastatic disease is lacking. Case report Herein, we describe a patient with relapsed, metastatic squamous cell carcinoma of the anal canal treated with cetuximab as the third-line therapy. Management and outcome: The patient responded to this pharmacological agent, meeting the definition of a partial response per response evaluation criteria in solid tumors (RECIST). Discussion EGFR inhibitors are potential avenues for the subsequent lines of therapy in metastatic or relapsed/refractory anal cancer. Prospective clinical trials of cetuximab alone or in combination with other agents are warranted in this setting in the future.
The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis
Authors: Denissen Stijn , De Cock Alexander , Meurrens Tom , Vleugels Luc , Van Remoortel Ann , Gebara Benoit , D’Haeseleer Miguel , D’Hooghe Marie B , Van Schependom Jeroen , Nagels Guy 
Published: November 2019

Background: Cognitive dysfunction is a frequent manifestation of multiple sclerosis (MS) but its effect on locomotor rehabilitation is unknown. Objective: To study the impact of cognitive impairment on locomotor rehabilitation outcome in people with MS. Methods: We performed a retrospective analysis involving ambulatory patients with MS who were admitted for intensive, inpatient, multidisciplinary rehabilitation at the National Multiple Sclerosis Center of Melsbroek between the years 2012 and 2017. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) was used to determine the cognitive status of subjects as either impaired (COG–) or preserved (COG+). Locomotor outcome was compared between groups with the difference in 6-minute walk test (6MWT) measured at admission and discharge (Δ6MWT). In addition, individual test scores of the BRB-N for attention (Paced Auditory Serial Addition Test 2” and 3”), visuospatial learning/memory (7/24 Spatial Recall Test), verbal learning/memory (Selective Reminding Test) and verbal fluency (Controlled Oral Word Association Test) were correlated to the Δ6MWT. Results: A total of 318 complete and unique records were identified. Both groups showed a significant within-group Δ6MWT during hospitalization (COG+: 47.51 m; COG–: 40.97 m; P < .01). In contrast, Δ6MWT values were comparable between groups. The odds of achieving a minimal clinical important difference on the 6MWT did not differ significantly between both groups. Only attention/concentration was significantly correlated with Δ6MWT (r = 0.16, P = .013). Conclusion: Cognitive impairment based on BRB-N results appears not to impede locomotor rehabilitation in ambulatory patients with MS. Attentional deficits are correlated to the extent of locomotor rehabilitation, suggesting the presence of a subtle effect of cognition.
Long Noncoding RNA GM16343 Promotes IL-36β to Regulate Tumor Microenvironment by CD8+T cells
Authors: Mao Deli , Hu Chenrui , Zhang Jianglei , Feng Chao , Zhang Zhe , Wang Jin , Man Zhongsong , Zhu Zhongwei , Wang Yunliang , Zhao Hua , Zhu Xinguo , Ouyang Jun , Dong Xiaoqiang , Zhao Xin 
Published: November 2019

Objective: To investigate the effect of long noncoding RNA GM16343 on interleukin 36β promotion of CD8+T cells in tumor microenvironment regulation. Methods: The differentially expressed long noncoding RNA in interleukin 36β-stimulated mouse CD8+T cells was screened by gene chip technology, and the significant differentially expressed long noncoding RNAs were verified by real-time polymerase chain reaction. The lentiviral vector that overexpresses or knockdown GM16343 was constructed, transfected into CD8+T cells, and stimulated with interleukin 36β, and the amount of interferon γ secreted was detected by enzyme-linked immunosorbent assay. A mouse subcutaneous xenograft model that stably express interleukin 36β was established, and the tumor size and mouse survival time were observed by stimulation with CD8+T cells overexpression or knockdown of GM16343. Results: A total of 12 long noncoding RNAs with significant differences were screened by gene chip analysis. Real-time polymerase chain reaction showed that the difference in GM16343 was larger, and the difference between the groups was observed to be the most significant. Compared to control group, CD8+T cells overexpressing GM16343 increased the secretion of interferon γ, and the tumor diameter of the mice after stimulation showed significant reduction, and the survival time showed significant prolongation. Compared to control group, the CD8+T cells after GM16343 were knocked down. The interferon γ secretion was decreased, and no significant change in tumor diameter and survival time was observed. Conclusion: Interleukin 36β may enhance antitumor immune response of CD8+T cells by regulating GM16343.
Mechanical thrombectomy with second-generation devices for acute cerebral middle artery M2 segment occlusion: A meta-analysis
Authors: Li Guangshuo , Huang Rui , Li Weishuai , Zhang Xiaotian , Bi Guorong 
Published: November 2019

Background The benefit of mechanical thrombectomy for an acute ischemic stroke involving M2 segment occlusion is not clear, especially when performed with second-generation thrombectomy devices. Method We reviewed the literature to investigate clinical outcomes and the rates of recanalization, symptomatic intracerebral hematoma, and mortality in mechanical thrombectomy performed using second-generation thrombectomy devices. We compared the outcomes between patients treated for M2 and M1 occlusions. Results Seven studies involving 805 patients with M2 thrombectomy were included in this meta-analysis. The functional independence rate 90 days after thrombectomy (modified Rankin Scale 0–2) was 59.3% (OR 1.81, 95% CI 1.74–1.88). The recanalization rate (thrombolysis in cerebral infarction 0–2) was 84.16% (OR 2.32, 95% CI 2.08–2.29). The symptomatic intracerebral hematoma rate was 4.9% (OR 1.05, 95% CI 1.03–1.09). The mortality was 7.7% (OR 1.08, 95% CI 1.03–1.13). The outcomes were better in patients with M2 occlusion than in those with M1 occlusion. In a subgroup analysis, we found that among patients with hypertension, mechanical thrombectomy achieved better functional outcomes and recanalization in M2 occlusion than M1 occlusion. Conclusion Mechanical thrombectomy performed with second-generation thrombectomy devices for M2 occlusion can provide a good functional outcome as well as satisfying recanalization. Moreover, there was no significant difference in the symptomatic intracerebral hematoma and mortality rates, suggesting this procedure is as safe in M2 occlusion as in M1 occlusion.
When the Wave Breaks You: Magnetic Resonance Imaging Findings After Surfing Injuries
Authors: Patel Bhumin J. , Heath Madison R. , Geannette Christian S. , Fabricant Peter D. , Greditzer Harry G. 
Published: November 2019

Background: There are approximately 2.1 million recreational surfers in the United States. However, little has been reported on surfing-related injuries and, to date, no study has utilized magnetic resonance imaging (MRI) to characterize injury patterns. Objective: To use MRI to perform a descriptive analysis of surfing injuries in patients who presented to an urban tertiary care musculoskeletal hospital. This was not a hypothesis-driven study. Study Design: Case series. Level of Evidence: Level 4. Methods: A retrospective review of the picture archiving and communication system as well as the electronic medical record was performed to identify patients with surfing-related injuries who presented to a tertiary care musculoskeletal hospital for treatment. The search included participants over a 10-year period who presented between January 1, 2009, and August 1, 2018. Descriptive data analyses were performed to determine frequency of body part injured, diagnosis, and operative versus nonoperative treatment. Results: The search yielded 109 patients with surfing-related injuries and MRIs. A total of 90 patients presented within 6 months of their surfing injury and were included in the final analysis. The median age was 36 years (range, 12-66 years). A majority of the patients included were male (74%; n = 67). Acute surfing injuries were diagnosed via imaging in 72% (n = 65) of patients. The joints injured most commonly were the shoulder (46%; n = 30) and the knee (28%; n = 18). Only 17% (n = 11) of acute surfing injuries required surgery, while 83% (n = 54) were treated nonoperatively. Conclusion: The most common surfing-related injuries occurred in the shoulder and knee. Clinical Relevance: This study helps characterize the risk of injury for surfers and informs healthcare providers on common surfing injuries.
Side Plank Pose Exercises for Adolescent Idiopathic Scoliosis Patients
Authors: Sarkisova Natalya , Andras Lindsay M , Yang Joshua , Zaslow Tracy L , Edison Bianca R , Tolo Vernon T , Skaggs David L 
Published: November 2019

Background Fishman et al. reported that side plank poses asymmetrically strengthened the convex side of the curve and decreased primary Cobb angle by 49% among compliant patients with adolescent idiopathic scoliosis (AIS). Methods AIS patients with curves of 10° to 45° were randomized into the front plank (control) or side plank group. The side plank was performed with their curve convex down. A weekly survey monitored compliance, defined by completing poses 4 or more times a week. Results A total of 64 patients were enrolled; 34% (22 of 64) of patients (mean age = 13 years) were compliant. In the control group, there were 11 compliant patients with 6 undergoing brace treatment. At enrollment, they had a mean Cobb angle of 30° (range: 14°–40°) and mean scoliometer reading of 13°. At 6 months, they had a mean Cobb angle of 30° (range: 14°–42°) and mean scoliometer of 12°. In the side plank group, there were 11 compliant patients with 5 undergoing brace treatment. At enrollment, they had a mean Cobb angle of 32° (range: 21°–44°) and mean scoliometer reading of 12°. At 6 months, they had a mean Cobb angle of 31° (range: 17°–48°) and a mean scoliometer reading of 13°. There were no significant changes in either the control or side plank group in regards to primary Cobb angle (control: P = .53, side plank: P = .67) or scoliometer (control: P = .22, side plank: P = .45). Conclusion There were no significant changes in primary Cobb angle or scoliometer after 6 months of side plank exercises. In contrast to a prior study, there was no improvement in curve magnitude in AIS patients performing side plank exercises.
Topology Consistency of Disease-specific Differential Co-regulatory Networks
Authors: Nazarieh Maryam , Rajula Hema Sekhar Reddy , Helms Volkhard 
Published: November 2019

Abstract

Background
Sets of differentially expressed genes often contain driver genes that induce disease processes. However, various methods for identifying differentially expressed genes yield quite different results. Thus, we investigated whether this affects the identification of key players in regulatory networks derived by downstream analysis from lists of differentially expressed genes.

Results
While the overlap between the sets of significant differentially expressed genes determined by DESeq, edgeR, voom and VST was only 26% in liver hepatocellular carcinoma and 28% in breast invasive carcinoma, the topologies of the regulatory networks constructed using the TFmiR webserver for the different sets of differentially expressed genes were found to be highly consistent with respect to hub-degree nodes, minimum dominating set and minimum connected dominating set.

Conclusions
The findings suggest that key genes identified in regulatory networks derived by systematic analysis of differentially expressed genes may be a more robust basis for understanding diseases processes than simply inspecting the lists of differentially expressed genes.