bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics and Adverse Clinical Outcomes of Invasive Haemophilus influenzae Serotype a Cases—United States, 2011–2015
Authors: Bozio Catherine H , Blain Amy , Edge Karen , Farley Monica M , Harrison Lee H , Poissant Tasha , Schaffner William , Scheuer Tara , Torres Salina , Triden Lori , Briere Elizabeth , Oliver Sara E 
Published: July 2020

Abstract

Background
Incidence of invasive disease due to Haemophilus influenzae serotype a (Hia) increased an average of 13% annually from 2002 through 2015. We describe clinical characteristics and adverse clinical outcomes of US invasive Hia cases detected through multistate surveillance during 2011–2015.

Methods
Medical record data were abstracted for cases reported in 8 jurisdictions conducting active population- and laboratory-based surveillance for invasive Hia disease across the United States. Isolates from sterile sites were serotyped using real-time polymerase chain reaction. Adverse clinical outcomes were defined as any possible complication of meningitis, bacteremic pneumonia, or bacteremia (including hearing loss and developmental delay, but excluding death) and were assessed at hospital discharge and one-year post-disease onset.

Results
During 2011–2015, 190 Hia cases were reported to the 8 participating sites; 169 (88.9%) had data abstracted. Many patients were aged &lt;5 years (42.6%). Meningitis was the most common clinical presentation among those aged &lt;1 year (71.4%); bacteremic pneumonia was the most common presentation among persons aged ≥50 years (78.7%). Overall, 95.9% of patients were hospitalized. Among those hospitalized, 47.5% were admitted to an intensive care unit and 6.2% died during hospitalization. At hospital discharge and one-year post-disease onset, adverse outcomes were identified in 17.7% and 17.8% of patients overall and in 43.9% and 48.5% of patients with meningitis (primarily children).

Conclusions
Hia infection can cause severe disease that requires hospitalization and may also cause short- and long-term adverse clinical outcomes, especially among children. Novel vaccines could prevent morbidity and mortality.
Towards a critical ontology of socio-economic transformation processes: Marx’s contribution
Authors: Bonifati Giovanni 
Published: July 2020

AbstractThe aim of the article is to contribute to a critical ontology of socio-economic transformation processes. Elements for such an ontology, it argues, can be found in the interaction between three foundational aspects of Marx’s thought: the notion of labour as a human social activity; the meaning and implications of the notion of alienation; and the relationship between quantitative and qualitative changes. After analysing these elements, the article discusses possible developments for an ontology of socio-economic transformation processes and concludes that Marx’s fundamental contribution to such an ontology is to show that the emergence of a new system of division of labour as a qualitative transformation requires a change in the relationships between the entities of an already existing system of division of labour that gives it a new functionality and a new direction. Marx teaches us that we need to identify the turning points in change processes and that, in this last respect, emergence is not a gradual process. The article argues that, in more general terms, the notion of emergence as a process of change in the functionality of an existing system of relationships to which a new direction is given can be used as a method to analyse socio-economic transformation processes at different levels of social reality. Thus understood, emergence involves the rejection of any form of reductionism in the social sciences.
House Prices and Growth with Fixed Land Supply
Authors: Miles David , Sefton James 
Published: July 2020

AbstractWe analyse housing costs and patterns of residential development over the long term in a dynamic general equilibrium. We show that in a growing economy the speed of travel improvements is crucial to the evolution of land and house prices. We derive a condition for the rate of change in transport efficiency that generates flat land and house prices on a balanced growth path. We present evidence that this condition was satisfied in many countries between the mid-nineteenth century and the mid-twentieth century, but since then passenger transport improvements have slowed down with major implications for how house prices evolve.
Ventricular assist device bridging with gender-mismatch increases rejection and decreases survival following a heart transplant
Authors: Itoda Yoshifumi , Okamoto Toshihiro , Niikawa Hiromichi , Ayyat Kamal S , Tu Chao , McCurry Kenneth R 
Published: July 2020

Abstract

OBJECTIVES

Survival is poor following an orthotopic heart transplant with gender-mismatched donors and recipients. Patients bridged to an orthotopic heart transplant with a ventricular assist device (VAD) frequently become sensitized. We hypothesized that the combination of VAD bridging and gender-mismatch may result in greater rejection and poorer survival.

METHODS
Data were obtained from the United Network of Organ Sharing database. Patients were divided into 4 groups: (i) VAD recipients who received a heart from a gender-matched donor (VAD-M); (ii) VAD recipients who received a heart from a gender-mismatched donor (VAD-MM); (iii) noVAD recipients who received a heart from a gender-matched donor (noVAD-M); and (iv) noVAD recipients who received a heart from a gender-mismatched donor (noVAD-MM). Rejection episodes within 1-year post-transplant and transplant survival were compared in VAD-M versus VAD-MM and noVAD-M versus noVAD-MM groups, respectively.

RESULTS
Between January 2000 and June 2017, of 33 401 adult patients who underwent heart transplants, 8648, 2441, 12 761 and 4992 patients were identified as VAD-M, VAD-MM, noVAD-M and noVAD-MM, respectively. Rejection within 1-year post-transplant occurred in 23.3% and 27.3% of the VAD-M and VAD-MM groups, respectively (P &lt; 0.01) and in 21.8% and 23.6% of the noVAD-M and noVAD-MM groups (P = 0.02), respectively. In an adjusted survival analysis, the VAD-MM group showed significantly worse survival than the VAD-M group (P &lt; 0.01), whereas there was no significant difference between the noVAD-M and noVAD-MM groups (P = 0.21).

CONCLUSIONS
Our results indicated that the combination of VAD bridging and gender-mismatch caused greater rejection and worse survival following a transplant. Further study is necessary to prove comparable post-transplant survival of gender-matched or -mismatched recipients without VAD bridging.
Tocqueville and the Consciousness of Capital (Reading The Ancien RÉgime with LukÁcs)
Authors: Dodman Thomas 
Published: July 2020

Abstract—
Since the 1970s, Alexis de Tocqueville’s The Ancien Régime and the French Revolution has provided an intellectual linchpin for revisionist accounts of the French Revolution as a political event, divorced from socioeconomic logics. This article offers an alternative reading of this classic text. It argues that Tocqueville’s analysis grapples at a fundamental level with social change and tries to grasp its manifestations in processes of bureaucratization and abstraction. Read alongside Georg Lukács’ seminal analysis of modern rationalization as reification, it offers a suggestive take on capitalist transformation in eighteenth and nineteenth-century France. I suggest that in our current historiographical conjuncture, Tocqueville’s analysis can serve as a point of departure to understanding how capitalism invests all spheres of life, both material and ideational.
Impact of Diabetes on Life and Healthy Life Expectancy Among Older Women
Authors: Wubishet Befikadu L , Byles Julie E , Harris Melissa L , Jagger Carol 
Published: July 2020

Abstract

Background
Diabetes is a major chronic condition with ever-increasing health and economic burden. This study aimed to measure the impact of diabetes on total life expectancy (TLE) and healthy life expectancy (HLE) at ages 70 and 80 and to assess how educational level, obesity, and comorbidity affected the expectancies.

Methods
The study involved 9849 population-representative women born between 1921 and 1926 from the Australian Longitudinal Study on Women’s Health (ALSWH). Self-rated health was obtained from the ALSWH surveys. Diabetes diagnosis was ascertained using survey and health care administrative data. Total life expectancy and HLE were estimated for women with and without diabetes using multistate modeling.

Results
Diabetes was associated with an increased risk of poor health (adjusted risk ratio: 1.63, 95% confidence interval: 1.49–1.79). Diabetes was also associated with a reduction of 0.9 years in HLE and 2.6 years in TLE at age 70 and 0.4 years in HLE and 1.3 years in TLE at age 80. If a woman had low education, obesity, and more than 2 comorbidities in addition to diabetes, these reductions increased to 3.0 years in TLE and 7.9 years in HLE at age 70 and 1.5 years in TLE and 3.8 years in HLE at age 80.

Conclusions
Diabetes substantially reduced older women’s quantity and quality of life, with further reductions for those with lower education, obesity, and comorbidities. These findings underscore the importance of optimally managing diabetes by maintaining a healthy weight and delaying the onset of comorbidities, to promote healthy aging for older women with diabetes.
Knowledge intermediation strategies: a dynamic capability perspective
Authors: Traoré Namatié , Amara Nabil , Rhaiem Khalil 
Published: July 2020

Abstract
This study investigates (i) differences in knowledge intermediation strategies among knowledge and technology transfer organizations (KTTOs) and (ii) the factors that explain such differences. It uses data from 212 Canadian KTTOs. When knowledge delivery capacity (KDC) and knowledge integration capacity (KIC) dimensions of knowledge intermediation are simultaneously accounted for, four categories of KTTOs emerge, namely, (1) knowledge stores; (2) knowledge match providers; (3) knowledge integrators; and (4) knowledge brokers. This heterogeneity results in a differentiation in KTTOs' service delivery strategies. Factors that are conducive to custom-made solutions include (i) increased innovativeness; (ii) higher absorptive capacity; (iii) stronger information search and storage capabilities; (iv) effective customer knowledge management (CKM); and (v) increased networking capabilities. Larger knowledge intermediaries suffer from internal organizational stickiness that prevents them from delivering custom-made services. KTTOs with a low degree of formalization and centralization in decision-making are likely to adopt intermediation strategies aimed at reaching the largest possible number of users. Some managerial and public policy implications are drawn.
Smart advertising and online dictionary usefulness
Authors: Dziemianko Anna 
Published: July 2020

AbstractToday, online advertisements are smart. Based on targeting, they are highly personalized to match the interests of Internet users. Smart advertisements feature even in high-quality online dictionaries, which is a trade-off for free dictionary content. The aim of the paper is to investigate the influence of targeted advertisements in online dictionaries on language reception, production and learning. The study also identifies the effect of advertisement targeting on the time of online dictionary consultation. In addition, dictionary users’ attitudes to advertisements are explored. The results reveal that either targeted or non-targeted advertisements in online dictionaries do not significantly affect language reception, production and learning, irrespective of sense position in entries. Yet, both targeted and non-targeted advertisements prolong dictionary consultation. Non-targeted advertisements were found only marginally more disruptive than targeted ones, and the assessment of advertisements was not dependent on the experimental condition.
Modelling the order of scoring in team sports
Authors: Hamada Kengo , Tanaka Ken-ichi 
Published: July 2020

AbstractThis paper considers sports matches in which two teams compete to score more points within a set amount of time (e.g. football, ice hockey). We focus on the order in which the competing teams score during the match (order of scoring). This type of order of scoring problem has not been addressed previously, and doing so here gives new insights into sports matches. For example, our analysis can deal with a situation that spectators find matches that involve comebacks particularly exciting. To describe such problems mathematically, we formulate the probabilities of (i) the favourite team leading throughout the match and (ii) the favourite team falling behind the opposing team but then making a comeback. These probabilities are derived using an independent Poisson model and lattice path enumeration, the latter of which involves the well-known ballot theorem. The independence assumption allows lattice path enumeration to be applied directly to the Poisson model and various scoring patterns to be addressed. We confirm that the values obtained from the proposed models agree well with actual sports data from football, futsal and ice hockey.
Analysis of an interior penalty DG method for the quad-curl problem
Authors: Chen Gang , Qiu Weifeng , Xu Liwei 
Published: July 2020

Abstract
The quad-curl term is an essential part of the resistive magnetohydrodynamic equation and the fourth-order inverse electromagnetic scattering problem, which are both of great significance in science and engineering. It is desirable to develop efficient and practical numerical methods for the quad-curl problem. In this paper we first present some new regularity results for the quad-curl problem on Lipschitz polyhedron domains, and then propose a mixed finite element method for solving the quad-curl problem. With a novel discrete Sobolev imbedding inequality for the piecewise polynomials, we obtain stability results and derive error estimates based on a relatively low-regularity assumption of the exact solution.
Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults: A Randomized, Placebo-Controlled, Phase 2 Study
Authors: Sirivichayakul Chukiat , Barranco-Santana Elizabeth A , Rivera Inés Esquilín , Kilbury Jennifer , Raanan Marsha , Borkowski Astrid , Papadimitriou Athanasia , Wallace Derek 
Published: July 2020

Abstract

Background
We report long-term safety and immunogenicity of Takeda’s tetravalent dengue vaccine candidate (TAK-003) in healthy children and adults living in dengue-endemic areas in Puerto Rico, Columbia, Singapore, and Thailand.

Methods
In part 1 of this phase 2, randomized, placebo-controlled trial we sequentially enrolled 1.5–45 year olds (n = 148) into 4 age-descending groups, randomized 2:1 to receive 2 doses of TAK-003 or placebo 90 days apart. In part 2, 1–11 year olds (n = 212) were enrolled and randomized 3:1 to TAK-003 or placebo groups. We assessed neutralizing antibody titers for the 4 dengue serotypes (DENV) up to month 36 in part 1, and symptomatic dengue and serious adverse events (SAEs) up to month 36 in both parts.

Results
At month 36, seropositivity rates were 97.3%, 98.7%, 88.0% and 56.0% for DENV-1, -2, -3 and -4, respectively. Seropositivity rates varied significantly for DENV-4 according to serostatus at baseline (89.5% in seropositives versus 21.6% in seronegatives). No vaccine-related SAEs were reported.

Conclusions
The trial demonstrated persistence of neutralizing antibody titers against TAK-003 over 3 years in children and adults living in dengue-endemic countries, with limited contribution from natural infection. TAK-003 was well tolerated.

Clinical Trials Registration
NCT01511250
GBDT version of the Darboux transformation for the matrix coupled dispersionless equations (local and non-local cases)
Authors: Popovych Roman O , Sakhnovich Alexander L 
Published: July 2020

AbstractWe introduce matrix coupled (local and non-local) dispersionless equations, construct GBDT (generalized Bäcklund-Darboux transformation) for these equations, derive wide classes of explicit multipole solutions, give explicit expressions for the corresponding Darboux and wave matrix valued functions and study their asymptotics in some interesting cases. We consider the scalar cases of coupled, complex coupled and non-local dispersionless equations as well.
Small Pediatric Burns Can Be Safely Managed on an Outpatient Basis
Authors: Grote Andrea C , Lacey Alexandra M , Garner Warren L , Gillenwater Timothy Justin , Maniago Ellen , Yenikomshian Haig A 
Published: July 2020

Abstract
American Burn Association (ABA) guidelines recommend that all pediatric burns be transferred to a burn center if their presenting hospital lacks the necessary personnel or equipment for their care. Our institution often treats small burns (&lt;10% TBSA) in pediatric patients in an ambulatory setting with a nondaily dressing. The aim of this study was to determine whether small pediatric burns could be safely managed on an outpatient basis. A retrospective review at a single ABA-verified burn center was conducted, including 742 pediatric patients presenting to the burn evaluation clinic in a 3-year period. Postburn day, age, sex, TBSA, burn etiology, body area burned, burn dressing type, outpatient versus inpatient management, reason(s) for admission, and any operative intervention were collected. Overall, the most common burn etiologies were scald (68%), contact (20%), and flame (5%). In this cohort, 14% (101) of patients were admitted on evaluation to the burn center with a mean TBSA of 9%. The remaining 86% (641) of patients were treated outpatient with a mean TBSA of 3%. Of those who were treated outpatient, 96% (613) successfully completed outpatient care and 4% (28) were subsequently admitted. The patients who were successfully managed in an ambulatory setting had a mean TBSA of 3%, whereas the patients who failed outpatient care had a mean TBSA of 4%. The primary reason for the subsequent admission of these patients was nutrition optimization (61%). The vast majority of small pediatric burns can be effectively treated on an outpatient basis with a nondaily dressing.
Fistulotomy-First Approach is Safe and Effective in Endoscopic Retrograde Cholangiography: Results of a Prospective Case Series
Authors: Hnaris Konstantinos , Taylor Connie , Hookey Lawrence , Bechara Robert 
Published: July 2020

Abstract

Background and Aims
The aim of this study was to assess the safety and efficacy of using needle-knife fistulotomy (NKF) as a primary cannulation technique in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) with a native papilla.

Patients and Methods
This prospective feasibility study enrolled 50 patients between December 2018 and June 2019. The procedure was performed by two expert endoscopists (R.B. and L.H.). The primary outcome was the incidence of post-ERCP pancreatitis. Other variables assessed included the success rate of cannulation of the common bile duct (CBD), time to successful cannulation, and incidence of adverse events.

Results
Between December 2018 and June 2019, 50 patients enrolled in the study. The mean age was 63.4 years (standard deviation 18.1), and there were 26 females. Indications included biliary obstruction secondary to malignancy (n = 14) and choledocholithiasis (n = 36). Successful cannulation of the CBD through the fistulotomy occurred in 49/50 cases. The time to successful cannulation was 5.1 minutes (range 0.5 to 23 minutes). Mild acute pancreatitis occurred in two cases (4%). Post-ERCP bleeding occurred in three patients (6%)

Conclusions
In this pilot study, NKF was used as the primary biliary access technique and it was demonstrated that it appears to be at least as safe as the traditional access technique with a sphinctertome. However, its role as a primary cannulation technique requires further investigation with multicenter, randomized control studies.
Biting Midges in Jamari National Forest, in the Brazilian Amazon, With 12 New Records of Culicoides Species (Diptera: Ceratopogonidae) for the State of Rondônia
Authors: Carvalho Luis Paulo Costa , Pereira Júnior Antônio Marques , Pessoa Felipe Arley Costa , Medeiros Jansen Fernandes 
Published: July 2020

Abstract
Culicoides biting midges are small hematophagous flies, some species of which transmit pathogens to livestock and humans. In the Brazilian Amazon Basin, Culicoides diversity has remained largely unexamined. Jamari National Forest (JNF) is a conservation area in Rondônia State where research and environmental education are conducted in conjunction with the protection of natural resources, and the recovery of degraded areas. The present study augments our knowledge of Culicoides diversity in JNF. The survey collected 640 individuals from 41 species; 632 individuals were collected by HP light trap and 8 were collected by the BG Sentinel trap. Twelve species are first-time records for Rondônia: Culicoides acotylus Lutz, Culicoides albuquerquei Wirth & Blanton, Culicoides baniwa Felippe-Bauer, Culicoides bricenoi Ortiz, Culicoides brownei Spinelli, Culicoides carsiomelas Wirth & Blanton, Culicoides debilipalpis Lutz, Culicoides forattinii Ortiz, Culicoides ginesi Ortiz, Culicoides profundus Santarém, Felippe-Bauer & Trindade, Culicoides pseudoreticulatus Santarém, Felippe-Bauer & Castellón, and Culicoides spurius Santarém, Felippe-Bauer & Trindade. The most abundant species were Culicoides glabrior Macfie, Culicoides pseudodiabolicus Fox, Culicoides debilipalpis, Culicoides quasiparaensis Clastrier, and Culicoides brownei Spinelli. The present study updates the Culicoides species count in Rondônia to 55, and highlights the importance of JNF as a hotbed for biting midge diversity.
Music Therapy to Regulate Arousal and Attention in Patients With Substance Use Disorder and Posttraumatic Stress Disorder: A Feasibility Study
Authors: Hakvoort Laurien , de Jong Sirik , van de Ree Maartje , Kok Tim , Macfarlane Clare , de Haan Hein 
Published: July 2020

AbstractPatients diagnosed with both substance use disorder (SUD) and posttraumatic stress disorder (PTSD) often experience hypervigilance, increased fear, and difficulties regulating emotions. This dual diagnosis increases treatment complexity. Recently, a short-term music therapy intervention for arousal and attention regulation (the SMAART intervention) was designed based on neurobiological findings. Twelve patients with SUD and PTSD (50% females) in outpatient treatment participated in six weekly one-hour sessions of the SMAART intervention. Six patients completed the study. PTSD symptom severity was evaluated with the Posttraumatic Stress Disorder Symptom Scale Interview for DSM–5 (PSSI-5) pre- and post-intervention, and sustained attention was evaluated with the Bourdon–Wiersma (BW) test. A significant difference in measurements for the PSSI-5 overall symptom severity was found pre- and post-intervention. Furthermore, participants showed significant improvement on subscales of hyperarousal, mood and cognition, and attention. The BW test completion time decreased significantly. Two participants dropped out before the end of the intervention due to craving. Concerning future research, it is recommended to define the role of the music more explicitly and to change the design to a randomized controlled trial. A risk for future larger studies is a high dropout rate (50%). Several limitations of the study are discussed.