bluuebunny/crossref_metadata_2025_split huggingface dataset:
World trends in sugar-sweetened beverage and dietary sugar intakes in children and adolescents: a systematic review
Authors: Della Corte Karen , Fife Jessica , Gardner Alexis , Murphy Britta L , Kleis Linda , Della Corte Dennis , Schwingshackl Lukas , LeCheminant James D , Buyken Anette E 
Published: June 2020

Abstract

Objective
To provide a systematic overview of world dietary sugar and sugar-sweetened beverage (SSB) intake trends in children and adolescents.

Data Sources
Medline, Embase, and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched through January 2019 to identify longitudinal follow-up studies with time-trend data and repeated cross-sectional studies.

Data Extraction
Data from studies reporting ≥ 2 measurements (sugars, SSB, or sweets/candy) over ≥ 2 years and included ≥ 20 healthy, normal- or overweight children or adolescents aged 1–19 years.

Data Analysis
Data from 43 articles (n = 4 prospective cohort studies; n = 39 repeated cross-sectional studies) from 15 countries (n = 8 European countries plus Australia, Canada, China, South Korea, Mexico, Russia, and the United States) are presented narratively. According to the risk of bias in nonrandomized studies of interventions tool, 34 studies were judged to have a moderate risk of bias, and 5 to have a serious risk of bias.

Conclusions
Consumption among US children and adolescents increased substantially in the decades preceding 2000, followed by a faster and continued decline. As a whole, other international intake trends did not reveal drastic increases and decreases in SSB and dietary sugars; they tended to change only slightly across 3 decades.
Digitization of the approach to food and nutrition respecting individual health values
Authors: Nomura Shuhei , Miyata Hiroaki 
Published: June 2020

Abstract
Japan’s aging population and increasing medical costs threaten the sustainability of its healthcare system. Society 5.0, Japan’s growth strategy, calls for a paradigm shift in healthcare based on digital technology. Health is a topic of great public concern, and diet and nutrition are at the heart of health. Many different values are used to define health, and Society 5.0 focuses on creating personalized values for different styles of eating and health. Health is already at the core of global business, and Japan, which is ahead of the rest of the world in its super-aging society, has a unique opportunity to be the first to create new business solutions for diet and nutrition.
Unravelling the panel contribution upon peer review evaluation of numerous, unstructured and highly interdisciplinary research proposals
Authors: Baimpos Theodoros , Dittel Nils , Borissov Roumen 
Published: June 2020

Abstract
In this study, we analyze the two-phase bottom-up procedure applied by the Future and Emerging Technologies Program (FET-Open) at the Research Executive Agency (REA) of the European Commission (EC), for the evaluation of highly interdisciplinary, multi-beneficiary research proposals which request funding. In the first phase, remote experts assess the proposals and draft comments addressing the pre-defined (by FET-Open) evaluation criteria. In the second phase, a new set of additional experts (of more general expertise and different from the remote ones), after cross reading the proposals and their remote evaluation reports, they convene in an on-site panel where they discuss the proposals. They complete the evaluation by reinforcing per proposal and per criterion one or another assessment, as assigned remotely during the first phase. We analyze the level of the inter-rater agreement among the remote experts and we identify its relative correlation with the funded proposals resulted after the end of the evaluation. Our study also provides comparative figures of the evolution of the proposals` scores during the two phases of the evaluation process. Finally, by carrying out an appropriate quantitative and qualitative analysis of all scores from the seven past cut-offs, we elaborate on the significant contribution of the panel (the second phase of the evaluation) in identifying and promoting the best proposals for funding.
Prevalence rates and correlates of insomnia disorder in post-9/11 veterans enrolling in VA healthcare
Authors: Colvonen Peter J , Almklov Erin , Tripp Jessica C , Ulmer Christi S , Pittman James O E , Afari Niloofar 
Published: June 2020

Abstract

Study Objectives
Post-9/11 veterans are particularly vulnerable to insomnia disorder. Having accurate prevalence rates of insomnia disorder in this relatively young, diverse population, is vital to determine the resources needed to identify and treat insomnia disorder. However, there are no accurate prevalence rates for insomnia disorder in post-9/11 veterans enrolling in the VA Healthcare System (VHA). We present accurate prevalence of insomnia disorder, and correlates, in a large sample of post-9/11 veterans enrolling in a VHA.

Methods
This was an observational study of 5,552 post-9/11 veterans newly enrolling for health care in a VHA. Data were collected using VA eScreening. Insomnia diagnosis was determined using a clinical cutoff score of ≥ 11 on the Insomnia Severity Index. Measures also included sociodemographic, service history, posttraumatic stress disorder (PTSD), depression, suicidal ideation, alcohol misuse, military sexual trauma, traumatic brain injury (TBI), and pain intensity.

Results
About 57.2% of the sample population had insomnia disorder. Our sample was nationally representative for age, sex, ethnicity, branch of the military, and race. The sample also was at high-risk for a host of clinical disorders, including PTSD, TBI, and pain; all of which showed higher rates of insomnia disorder (93.3%, 77.7%, and 69.6%, respectively).

Conclusions
The findings suggest alarmingly high rates of insomnia disorder in this population. Examining and treating insomnia disorder, especially in the context of co-occurring disorders (e.g. PTSD), will be a necessity in the future.
Shareholder Foundations of enterprises: the North European style of securing family businesses for the long term—rising up to the global challenge
Authors: Koele Ineke A , Feldthusen Rasmus K 
Published: June 2020

Abstract
This article explores how and why the traditional business succession system within family businesses needs to be reconsidered. Holding Foundations are generally overlooked although they provide a purpose-driven ownership structure with a stewardship governance that avoids family conflicts, taxation and dispersed ownership affecting the family business. In this article, the authors combine their experiences and insights from Denmark and the Netherlands with shareholder foundations of enterprises.
Comparing Surgical Experience and Skill Using a High-Fidelity, Total Laparoscopic Hysterectomy Model
Authors: Arora Chetna , Menzies Anya , Han Esther S. , Lee Minyi , Lauer Jacob K. , Hur Hye-Chun , Kim Jin Hee , Advincula Arnold P. 
Published: June 2020

OBJECTIVE:
To evaluate differences in standardized scores and surgical confidence in the completion of a standardized total laparoscopic hysterectomy and bilateral salpingo-oophorectomy (TLH-BSO) among obstetrician–gynecologists (ob-gyns) with different levels of training, and to assess a TLH-BSO model for validity.

METHODS:
We conducted a prospective cohort study of 68 participants within four categories of ob-gyns: 1) graduating or recently graduated residents (n=18), 2) minimally invasive gynecologic surgery graduating or recently graduated fellows (n=16), 3) specialists in general obstetrics and gynecology (n=15), and 4) fellowship-trained minimally invasive gynecologic surgery subspecialists (n=19) who completed a TLH-BSO simulation. Participants completed presimulation questionnaires assessing laparoscopic confidence. Participants performed a video-recorded TLH-BSO and contained specimen removal on a standardized 250-g biological model in a simulated operating room and completed a postsimulation questionnaire.

RESULTS:
Randomized videos were scored by blinded experts using the validated OSATS (Objective Structured Assessment of Technical Skills). The surgery was divided into five standardized segments: 1) adnexa, 2) dissection and pedicles, 3) colpotomy, 4) cuff closure, and 5) tissue extraction. Minimally invasive gynecologic surgery subspecialists averaging 8.9 years in practice scored highest in all categories (overall median score 91%, P<.001), followed by fellows (64%, P<.001), specialists in obstetrics and gynecology averaging 19.7 years in practice (63%, P<.001), and residents (56%, P<.001). Residents, fellows and specialists in obstetrics and gynecology were comparable overall. Fellows scored higher on cuff closure (63% vs 50%, P<.03) and tissue extraction (77% vs 60%, P<.009) compared with specialists in obstetrics and gynecology. Minimally invasive gynecologic surgery subspecialists were fastest overall and on each individual component. Residents were slowest in almost all categories.

CONCLUSION:
When performing a TLH-BSO of a standardized 250-g uterus on a simulation model, fellowship-trained minimally invasive gynecologic surgery subspecialists achieved higher OSATS in all areas and completed all components faster. Similar performances were noted between residents, fellows, and specialists in obstetrics and gynecology in practice an average of 19.7 years.

FUNDING SOURCE:
Support from Applied Medical, Medtronic, CooperSurgical, and Karl Storz in the form of in-kind equipment was obtained through unrestricted educational grants.
Relationship between social capital and heroin use behaviors among patients in methadone maintenance treatment in Sichuan Province, China
Authors: Yang Shifan , Gao Bo , Gu Jing , Gong Yi , Yu Bin , Han Jiayu , Dong Peijie , Jia Peng , Yang Shujuan 
Published: June 2020

Abstract
Covertly using heroin during methadone maintenance treatment (MMT) is very common among heroin-dependent patients, which has posed threats to the physical health of heroin-dependent patients and social safety. Covertly using heroin may be influenced by many factors, especially social capital. Therefore, we aimed to investigate the relationship between behaviors of covertly using heroin during MMT and social capital heroin-dependent patients in Sichuan Province, China. A cross-sectional study was conducted between October and November 2018, with a total of 581 heroin-dependent patients participating in the study. In addition to socio-demographic characteristics and heroin use related behaviors, the questionnaire also included the measures of social capital: social network (SN), social support (SP), community participation (CP) and social trust (ST). Multivariate logistic regression analyses were used to estimate the association between different measures of social capital and heroin use. The prevalence of covertly using heroin of heroin during MMT was 31.0% among our participants in the 6 months before the study. After adjusting for socio-demographic factors and heroin-use related variables, SN (OR = 0.85, 95% CI: 0.76–0.95), SP (OR = 0.89, 95% CI: 0.83–0.95), and ST (OR = 0.88, 95% CI: 0.81–0.95) were significantly associated with heroin use. Results suggest that social capital may have a protective effect on behavior of covertly using heroin during MMT, which should be consider in the interventions for heroin-dependent patients, in order to reduce the incidence of heroin use during MMT as well as improve the compliance of MMT.
Psychometric testing of a short form, 11-item Tampa Scale of Kinesiophobia–Arabic version
Authors: AL-Shudifat Abdulrahman , Farah Kawthar , Hawamdeh Ziad M. , Alqudah Ashraf , Juweid Malik E. 
Published: June 2020

Abstract
To examine the psychometric properties of a short form TSK-AV in Arabic-speaking patients with chronic low back pain (CLBP).
One hundred one CLBP patients recruited from Jordan University Hospital provided demographic information and completed the TSK-AV full version and measures of pain severity and disability. Explorative factor analysis was used to determine whether a generally accepted 2-factor model consisting of fewer TSK items applies to the TSK-AV and exhibits acceptable psychometric properties.
A 2-factor model provided an adequate-to-good fit to our data, explaining 46.54% of the variance. Factor 1 (labeled as “activity avoidance”) comprised items 1, 2, 7, 9, 14, 15, and 17. Factor 2 was labeled as “somatic focus” and comprised items 3, 6, 11, and 13. The 11-item TSK-AV comprised of the 2 factors (TSK-AV-11) as well as its subscales all remained independent significant (P < .001) predictors of pain disability in Jordanian patients with CLBP after accounting for factors such as age, gender, pain duration, and pain severity.
The short, 11-item TSK-AV (TSK-AV-11) appears to be an ideal clinical and research tool for measuring fear of movement/re (injury) in Arabic-speaking patients.
Mitochondrial DNA 10158T>C mutation in a patient with mitochondrial encephalomyopathy with lactic acidosis, and stroke-like episodes syndrome
Authors: Wang Shuai , Song Tao , Wang Suping 
Published: June 2020

Abstract

Rationale:
Mitochondrial encephalomyopathy with lactic acidosis and stroke- like episodes (MELAS) syndrome is caused by mitochondrial respiratory chain dysfunction and oxidative phosphorylation disorder. It is a rare clinical metabolic disease involved with multiple systems.

Patient concerns:
A 22-year-old patient presented with limb convulsion accompanied by loss of consciousness, headache, partial blindness, blurred vision, and so on.

Diagnoses:
Brain magnetic resonance imaging showed a high-intensity area in bilateral occipital cortex, left parietal lobe and cerebellum on diffusion-weighted imaging. These focus did not distribute as vascular territory. The pathological examination of skeletal muscle revealed several succinate dehydrogenase reactive vessels with overreaction and increased content of lipid droplets in some muscle fibers. Genetic testing showed that the patient carried m.10158T>C mutation.

Interventions:
She was provided with traditional arginine hydrochloride therapy and orally medication of coenzyme Q (10 mg).

Outcomes:
Mitochondrial DNA of blood and hair follicle of patient carried m.10158T>C mutation

Lessons:
For the suspected patients of MELAS syndrome, if the hot-spot mutation test is negative, more detection sites should be selected.
Association between non-alcoholic fatty liver and acute cerebral infarction: a protocol of systematic review and meta-analysis
Authors: Zhang Ya-Juan , Liu Wen-Juan 
Published: June 2020

Abstract

Background:
This study will systematically synthesize the evidence on the potential association between non-alcoholic fatty liver (NAFL) and acute cerebral infarction (ACI).

Methods:
We will propose literature search in electronic databases (MEDLINE, EMBASE, Cochrane Library, Scopus, Web of Science, WANGFANG, and China National Knowledge Infrastructure) from the source to March 1, 2020. There are no restrictions related to the language and publication status. Two review authors will separately carry out records selection, data extraction and study quality assessment. Any divisions will be solved by discussion with consulting a third review author. We will use RevMan 5.3 software to perform data analysis.

Results:
The present study will afford additional insight into the investigation the association between NAFL and ACI.

Conclusion:
The results of this study will provide helpful evidence to explore the association between NAFL and ACI.
Study registration number: INPLASY202040102.
Developing a template matching algorithm for benchmarking hospital performance in a diverse, integrated healthcare system
Authors: Molling Daniel , Vincent Brenda M. , Wiitala Wyndy L. , Escobar Gabriel J. , Hofer Timothy P. , Liu Vincent X. , Rosen Amy K. , Ryan Andrew M. , Seelye Sarah , Prescott Hallie C. 
Published: June 2020

Abstract
Template matching is a proposed approach for hospital benchmarking, which measures performance based on matching a subset of comparable patient hospitalizations from each hospital. We assessed the ability to create the required matched samples and thus the feasibility of template matching to benchmark hospital performance in a diverse healthcare system.
Nationwide Veterans Affairs (VA) hospitals, 2017.
Observational cohort study.
We used administrative and clinical data from 668,592 hospitalizations at 134 VA hospitals in 2017. A standardized template of 300 hospitalizations was selected, and then 300 hospitalizations were matched to the template from each hospital.
There was substantial case-mix variation across VA hospitals, which persisted after excluding small hospitals, hospitals with primarily psychiatric admissions, and hospitalizations for rare diagnoses. Median age ranged from 57 to 75 years across hospitals; percent surgical admissions ranged from 0.0% to 21.0%; percent of admissions through the emergency department, 0.1% to 98.7%; and percent Hispanic patients, 0.2% to 93.3%. Characteristics for which there was substantial variation across hospitals could not be balanced with any matching algorithm tested. Although most other variables could be balanced, we were unable to identify a matching algorithm that balanced more than ∼20 variables simultaneously.
We were unable to identify a template matching approach that could balance hospitals on all measured characteristics potentially important to benchmarking. Given the magnitude of case-mix variation across VA hospitals, a single template is likely not feasible for general hospital benchmarking.
Impressive long-term response with chemo-endocrine therapy in a premenopausal patient with metastatic breast cancer
Authors: Maltoni Roberta , Palleschi Michela , Gallerani Giulia , Bravaccini Sara , Cecconetto Lorenzo , Melegari Elisabetta , Altini Mattia , Rocca Andrea 
Published: June 2020

Abstract

Rationale:
Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with good quality of life. Rarely, exceptional responders achieve durable disease control, and potential cures cannot be ruled out.

Patient Concerns:
We report the case of a 39-year-old woman with primary breast cancer and associated synchronous bone metastases, who experienced a disease response of 12 years with hormonal therapy as maintenance after first line chemotherapy, with a good toxicity profile.

Diagnosis:
The patient was diagnosed with estrogen receptor + human epidermal growth factor receptor 2 (HER2)− metastatic breast cancer with synchronous bone metastases.

Interventions:
This patient was treated with chemotherapy for 6 cycles as a first-line therapy following by endocrine treatment given as a maintenance therapy.

Outcomes:
Our patient experienced a progression-free survival >12 years with an exceptionally good quality of life.

Lessons:
Our anecdotal experience highlights the existence of exceptional responders among patients with hormone receptor-positive metastatic breast cancer, who achieve clinical remission and durable disease control with endocrine therapy. Being able to identify these patients could help in the selection of the best treatment option among the many available.
The brain structure and function alterations in tension-type headache
Authors: Zhou Jun , Cheng Shirui , Yang Han , Lan Lei , Chen Yijia , Xu Guixing , Yin Zihan , Li Zhengjie , Liu Mailan 
Published: June 2020

Abstract

Objective:
The aim of this systematic review and meta-analysis is to improve the understanding of the pathophysiology of tension-type headache (TTH), as well as propose avenues for future neuroimaging studies of TTH.

Methods:
From the inception dates to May 1, 2020, a systematic literature will search in Medline (Ovid SP), Embase (Ovid SP), Cochrane Central Register of Controlled Trials, Web of Science, and 4 Chinese databases without limitation on language or publication. Additionally, International Clinical Trials Registry Platform , reference lists, and relevant gray literatures will be searched. After screening of eligible references, included studies will be determined according to included criteria, and then data extraction and a methodological quality assessment with a customized checklist will be conducted. Each process will be independently implemented by 2 reviewers, any disagreement will be resolved by consensus to the third researcher. If the extracted data is feasible, anisotropic effect-size version of signed differential mapping will be conducted to perform the meta-analysis of the structural and functional brain alterations in TTH patients.
The efficacy and safety of Jinhua Qinggan granule (JHQG) in the treatment of coronavirus disease 2019 (COVID-19)
Authors: Zhang Qiongshuai , Cao Fang , Wang Yufeng , Xu Xiaohong , Sun Yihan , Li Jiannan , Qi Xun , Sun Shaoqian , Ji Guangcheng , Song Bailin 
Published: June 2020

Abstract

Background:
Currently, the global number of infected novel coronavirus has exceeded 2.6 million and the death toll has exceeded 170,000, but the specific drug for the treatment of COVID-19 has been not appears. In the process of fighting COVID-19 in China, JHQG has been promoted by the Chinese government and widely used in the treatment of COVID-19. The purpose of this study is to systematically evaluate the efficacy and safety of JHQG for COVID-19.

Methods:
We are going to search the electronic databases: PubMed, EMBASE, Cochrane library, Web of Science (WOS), Google scholar, China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database (Wanfang) for published clinical trails and search clinical trials register platforms of Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov (www.ClinicalTrials.gov/) for ongoing trials of Jinhua Qinggan granule for COVID-19. The primary outcomes of the included studies contain Clinical symptom disappearance rate and the secondary outcomes obtain: TCM syndrome scale score, Hamilton anxiety scale score, and adverse events. We will use RevMan V5.3 software to perform the calculations. PRISMA-P checklist was used in writing this report.

Results:
The study results will be submitted to a peer-reviewed journal for publication.

Conclusion:
This study will provide a high-quality evidence of the efficacy and safety of Jinhua Qinggan granule on patients with COVID-19.

PROSPERO registration number:
CRD42020181919.