bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing Facies, Pore Types, and Diagenesis of a Subtidal to Peritidal Carbonate Platform for Defining Flow Units
Authors: Manifold Lucy , El-Bozie Ahmed , Hollis Cathy , Schröder Stefan 
Published: May 2020

Oil and gas reside in reservoirs within peritidal and shallow subtidal lagoonal carbonate sediments across the globe. This is a zone of facies heterogeneity, controlled by changes in depositional energy, water depth, clastic influx, and evapotranspiration. Close proximity to evaporitic brine pools means that it is also an environment with the potential for dolomitization during shallow burial. As a result, the original pore system of carbonate sediment can become drastically altered prior to burial, such that reservoir properties may not be predictable from facies models alone.
The Miocene Santanyí Limestone Formation, Mallorca, Spain, is well exposed and has undergone minimal burial and therefore presents an excellent opportunity to integrate sedimentology, facies architecture, and diagenesis to determine how porosity evolves within individual facies in the shallow subsurface. From here, the impact on pore type, pore volume, pore connectivity, and petrophysical anisotropy can be assessed. The Santanyí Limestone consists of pale mudstones and wackestones, rooted wacke-packstones, stratiform laminites, and skeletal and oolitic, cross-bedded grainstone. Thin-section analysis reveals a paragenetic pathway of grain micritization, followed by dissolution of aragonite, possibly by meteoric fluids associated with karstification. Subsequently, the unit underwent fracturing, compaction, recrystallization, cementation, dolomitization, and matrix dissolution to form vugs. Petrophysical analyses of 2.54-cm-diameter plugs indicate that these complex diagenetic pathways created petrophysical anisotropy [mean horizontal permeability (Kh)/vertical permeability (Kv) of whole formation = 3.4] and that measured parameters cannot be related directly to either geological facies or pore type. Instead, petrophysical data can be grouped according to the diagenetic pathways that were followed after deposition. The best reservoir quality (i.e., typical porosity 15 to &gt;40% and permeability &gt;100 mD) is associated with pale mudstones, stratiform laminites, and skeletal and oolitic grainstone that have undergone pervasive recrystallization or dolomitization. These rocks have the some of the lowest formation resistivity factor (FRF) values (&lt;200) and thus the simplest pore system. The poorest reservoir properties (k &lt;10 mD) occur in mudstones and wackestones that have not been recrystallized and, hence, are dominated by a simple network of micropores (FRF &lt;101). Skeletal and oolitic grainstones and rooted and brecciated wacke-packstones that have undergone some cementation and partial recrystallization have moderate reservoir properties and a high FRF (&gt;&gt;1000), reflecting a complex pore system of biomolds, vugs, and microporosity. Consequently, reservoir properties can be predicted based on their primary rock properties and the diagenetic pathway that they followed after deposition.
Impact of Hemodialysis and Post-Dialysis Period on Granular Activity Levels
Authors: Larkin John W , Han Maggie , Han Hao , Guedes Murilo H , Gonçalves Priscila Bezerra , Poli-de-Figueiredo Carlos Eduardo , Cuvello-Neto Américo Lourenço , Barra Ana Beatriz L , de Moraes Thyago Proença , Usvyat Len A , Kotanko Peter , Canziani Maria Eugenia F , Raimann Jochen G , Pecoits-Filho Roberto , Investigators For the HDFIT Study 
Published: May 2020

Abstract
Background: Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD and post-HD period on granular PA relative to HD timing. Methods: We used baseline data from the HDFIT trial conducted from August 2016 to October 2017. Accelerometry measured PA over one week in patients who received thrice-weekly high-flux HD (vintage 3 to 24 months), were clinically stable, and had no ambulatory limitations. PA was assessed on HD days (0 to ≤24 hours after start HD), first non-HD days (>24 to ≤48 hours after start HD) and second non-HD day (>48 to ≤72 hours after start HD). PA was recorded in blocks/slices: 4 hours during HD, 0 to ≤2 hours post-HD (30 minute slices), and >2 to ≤20 hours post-HD (4.5 hour slices). Blocks/slices of PA were captured at concurrent/parallel times on first/second non-HD days compared to HD days. Results: Among 195 patients (mean age 53±15 years, 71% male), step counts per 24-hours were 3919±2899 on HD days, 5308±3131 on first non-HD days (p<0.001), and 4926±3413 on second non-HD days (p=0.032). During concurrent/parallel times to HD on first and second non-HD days, patients took 1308 and 1128 more steps (both p<0.001). Patients took 276 more steps and had highest rates of steps/hour 2-hours post-HD versus same times on first non-HD days (all p<0.05). Consistent findings were observed on second non-HD days. Conclusions: PA was higher within 2-hours of HD versus same times on non-HD days. Lower PA on HD days was attributable to intradialytic inactivity. The established PA profiles are of importance to the design and development of exercise programs that aim to increase activity during and between HD treatments. Trial Registration: HDFIT was prospectively registered 20 April 2016 on ClinicalTrials.gov (NCT02787161) https://clinicaltrials.gov/ct2/show/NCT02787161.
Minority stress, depression, and cigarette smoking among Chinese gay versus bisexual men: A two-group structural equation model analyses
Authors: Li Jingjing , Huang Danqin , Windle Michael , Escoffery Cam , Wang Wei , Li Xiaoyan , Tao Kevin , Haardörfer Regine , Li Shiyue , Berg Carla J , Yan Hong 
Published: May 2020

Abstract
Background: Literature in the West suggested that bisexual men have a higher smoking rate compared to gay men. Data on patterns of smoking among gay and bisexual men are limited in Eastern Asian countries like China. This study examined the cigarette smoking prevalence for gay versus bisexual men in China and their unique minority stress - smoking pathways. Methods: Between September 2017 and November 2018, we surveyed a convenience sample of 538 gay men and 138 bisexual men recruited from local sexual minority organizations in four metropolitan cities in China (i.e., Beijing, Wuhan, Nanchang, and Changsha). Measures included sexual orientation, sociodemographics, theory-based minority stressors, depressive symptoms, and past 30-day cigarette smoking. Two-group (gay men vs. bisexual men) structural equation modeling (SEM) was used to test possible distinct mechanisms between theory-based stressors, depressive symptoms, and cigarette smoking among gay men and bisexual men, respectively. Results: The mean age of participants was 26.51 (SD = 8.41) years old and 76.3% of them had at least a college degree. Bisexual men reported a higher rate of cigarette smoking compared to gay men (39.9% vs. 27.3%). Two-group SEM indicated that the pathways for cigarette smoking were not different between gay and bisexual men. Higher rejection anticipation was associated with greater depressive symptoms (standardized β = 0.32, p < .001), and depressive symptoms were not associated with cigarette smoking. Conclusions: Minority stress, specifically rejection anticipation, may be critical considerations in addressing depressive symptoms, but not smoking, among both gay and bisexual men in China.
A health concept with a social potential: an interview study with nursing home residents
Authors: Vikström Sofia , Grönstedt Helena K. , Cederholm Tommy , Franzén Erika , Seiger Åke , Faxén-Irving Gerd , Boström Anne-Marie 
Published: May 2020

Abstract
Background A qualitative, interview-based study was embedded in a randomized intervention trial, the Older People Exercise and Nutrition (OPEN) study. Participants in the OPEN study were encouraged to conduct sessions of sit-to-stand (STS) exercises combined with Oral Nutritional Supplements (ONS) intake. The aim was to describe the older persons’ perceptions and experiences of being given the daily opportunity to perform the STS exercise and drink ONS. Methods In-depth interviews were conducted in six nursing homes with the participants using a semi-structured interview guide. One or two individual interviews were performed with each included participant. Twenty-three NH residents (16 women and 7 men) participated in the qualitative study. Their ages ranged between 76 and 96 years, and their Mini Mental State Examination (MMSE) scored between 8 and 29. The transcribed interviews and field notes written during the visits were analyzed inductively following a constant comparative method described in Grounded Theory. Results The exercise and nutritional intervention was described as highly practical by the NH residents, who claimed it also had a social aspect as they felt acknowledged and empowered to engage others in the combined intervention. Experiences of the intervention ranged from neutral to mainly positive and could be sorted into 5 categories: 1. Perceived hopes and expectations, 2. Health-related driving forces, 3. Appreciated daily activities, 4. A concept easy to perform and integrate into daily life, 5. A beneficial health concept for all. The intervention created perceived benefits on various health aspects due to participants feeling energized and stronger. An overall theme was identified as A health concept with a social potential, as participants feel acknowledged and strong enough to help others. Conclusions The intervention was described by participants as a health concept that could potentially be beneficial for a broader spectrum of NH residents. The findings indicate that health concepts, such as STS/ONS, might contribute to a more meaningful day for older people, even vulnerable NH residents approaching the end of life.
18 F-FDG uptake heterogeneity predicts KRAS/NRAS/BRAF mutation status in patients with liver metastases of colorectal cancer
Authors: Ma Guang , Zhang Fangsong , Liu Qiufang , Pan Lingling , Zhang Jianping , Zhang Yingjian , Song Shaoli 
Published: May 2020

Abstract
Background

Cetuximab and Panitumumab,serve as monoclonal antibodies against the epidermal growth factor receptor (EGFR), have been used in the treatment of metastatic colorectal cancer. However, mutations in KRAS, NRAS, BRAF indicate a lack of response to treatment for EGFR. The identification of KRAS/NRAS/BRAF mutation status is important to improve the success rate of this therapy. PET/CT imaging is a biomolecular imaging technique that can supply various information about malignant tumors. Hence, we investigated whether KRAS/NRAS/BRAF mutation status is related to 18F-FDG uptake heterogeneity in liver metastases of colorectal cancer, and whether 18F-FDG PET / CT imaging can predict the status of KRAS / NRAS / BRAF mutation and guide treatment of liver metastases of colorectal cancer in this study.
Methods

60 patients with liver metastases of colorectal cancer (lmCRC) were analysed retrospectively who had received 18F-FDG PET / CT before surgical operation. Heterogeneity index (HI) was defined by divided SUVmax by SUVmean. HI were assessed for patient (-P), colorectal cancer (-T) and liver metastatic lesions (-L).
Results

HI-L was significantly higher in NRAS/ KRAS/BRAF mutation group than in NRAS/ KRAS/BRAF wild-type group (2.48 ± 0.69 and 2.05 ± 0.31, respectively; p = 0.01). The groups of the number of liver metastatic sites were significantly different (p = 0.02). In multivariate analysis, HI-L was only significantly associated with KRAS/NRAS/BRAF mutation status (p = 0.008). Using a HI-L cut-off of 2.12, the sensitivity and specificity of predicting KRAS/NRAS/BRAF mutation were 72.7% and 70.4%, respectively.
Conclusions

Higher HI-L is associated with elevated NRAS/KRAS/BRAF mutation status in patients with lmCRC. 18F-FDG PET/CT can be used to predict the KRAS/NRAS/BRAF mutation status of lmCRC and to select the optimal therapeutic strategy.
Radiation therapy for parotid gland tumors: long term data from a large single Institution experience.
Authors: Tomasini Davide , Maddalo Marta , Borghetti Paolo , Triggiani Luca , Magli Alessandro , Bonù Marco Lorenzo , Guerini Andrea , Alghisi Alessandro , Costantino Gianluca , Bertagna Francesco , Albano Domenico , Mazzola Rosario , Ricchetti Francesco , Spiazzi Luigi , Buglione Michela , Magrini Stefano Maria 
Published: May 2020

Abstract
Background

parotid gland tumors (PGT) are rare entities. Surgery plays a key role in the treatment of PGT, post-operative radiation therapy (PORT) is necessary in order to reduce the recurrence rates. Histological subtypes (HS) and differentiation grade (DG) are extremely various and so is their clinical behavior. This large retrospective paper aims to identify factors associated with treatment toxicity, loco-regional recurrence and survival in patients with PGT.
Methods

152 patients with PGT were treated with surgery and PORT at our Department between 1992 and 2019. Medical records reported patients, disease and treatment characteristics, acute and late toxicities. Loco-regional control (LC), overall survival (OS), cancer specific survival (CSS) and metastases free survival (MFS) were analyzed as outcome endpoints.
Results

severe (> G2) acute mucositis and dermatitis were 20% and 10% respectively. Severe acute mucositis was reported more frequently in patients treated with > 60 Gy on tumor bed (p = .001) and in patients treated also on the neck (p = .006). The most frequent reported late toxicities were skin fibrosis (any grade) and xerostomia (≤ G2), 67% and 50% respectively. LC, OS, CSS and MFS rates at 10 year were respectively 67, 64, 76, 80 (%). Better Karnofsky Performance Status at diagnosis, more favorable HS, well differentiated PGT, less advanced pathological stage and the absence of nodal disease are related with better survival outcomes.
Conclusion

our data are in line with current literature: high grade and locally advanced PGT have the worst prognosis. Clinical trials are needed to define better treatment strategies for PGT.
Targeting Nerve Growth Factor, a new option for treatment of osteoarthritis: A Network meta-analysis of comparative efficacy and safety with traditional drugs
Authors: Cao Ziqin , Dou Pengcheng , Long Zeling , Li Yihan , Sun Jingjing , Zhou Jian , Wang Wanchun 
Published: May 2020

Abstract
BACKGROUND: Osteoarthritis (OA) is the most common joint disease and leading cause of pain and disability in the elderly population. Most guidelines recommend the use non-steroidal anti-inflammatory drugs (NSAIDs) and opioids for the non-operative treatment of OA. Monoclonal NGF antibodies are potential for pain relief and function improvement of OA. We conducted this network meta-analysis to comprehensively compare the efficacy and safety of monoclonal NGF antibodies with NSAIDs and opioids for OA. METHODS: Relevant studies, published up to January 2020, were included from PubMed, CKNI and Web of Science databases. Bayesian network and conventional meta-analyses were conducted. Pain relief, function improvement and risk of adverse effects (AEs) were assessed. RESULTS: 38 articles, comprising 41 trials (20489 patients with OA) were included. Overall, Anti-NGF was the most efficacious drug for pain relief (SMD compared with placebo 4.25, 95% CIs [2.87 to 5.63], SUCRA=93.7%) and (SMD 4.90, 95% CIs [3.46 to 6.33], SUCRA=98.3%). Although Anti-NGF was associated with higher risk of peripheral sensation abnormality (paresthesia and pruritus), it was not associated with higher withdrawal rates due to AEs and ohter AEs. CONCLUSIONS: The results show that monoclonal NGF antibodies significantly relieve pain due to OA and improve function, compared to selective cox-2 inhibitions, NSAIDs, and opioids. The monoclonal NGF antibodies are not associated with severe AEs. However, there is need to conduct more studies to confirm the findings of this study.
Serum Globulin and Albumin to Globulin Ratio as Potential Diagnostic Biomarkers for Periprosthetic Joint Infection: A Retrospective Review
Authors: Ye Yongyu , Chen Weishen , Gu Minghui , Xian Guoyan , Pan Baiqi , Zheng Linli , Zhang Ziji , Sheng Puyi 
Published: May 2020

Abstract
Background: Periprosthetic joint infection (PJI) has been increasingly documented; however, its preoperative accurate diagnosis remains challenging. Furthermore, there is a dire need to identify appropriate and effective biomarkers. We aimed to evaluate the relationship between globulin, albumin to globulin (A/G) ratio, and development of PJI in patients undergoing revision total joint arthroplasty (TJA). Methods: A retrospective study was conducted on patients who had undergone revision TJA between 2011 and 2018 (89 with aseptic mechanic failure and 38 with PJI). The serum proteins were explored using univariate analysis followed by multivariate logistic regression. The diagnostic performance of these proteins was assessed by the receiver operating characteristic (ROC) curve. Results: Higher globulin levels (odds ratio [OR], 1.239; P<0.001) and lower A/G ratio (OR, 0.007; P<0.001) were strongly associated with the risk of PJI. ROC curve analysis demonstrated reasonable diagnostic performance for globulin (area under the curve [AUC], 0.77; sensitivity, 78.95%; and specificity, 69.66%) and A/G ratio (AUC, 0.779; sensitivity, 65.79%; and specificity, 78.65%). Conclusions: Both globulin and A/G ratio were associated with PJI and may serve as potential adjuvant biomarkers in the diagnosis of PJI.
Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota
Authors: Tolnai Emese , Fauszt Peter , Fidler Gabor , Pesti-Asboth Georgina , Szilagyi Endre , Stagel Anikó , Konya Jozsef , Szabo Judit , Stundl Laszlo , Babinszky Laszlo , Biro Sandor , Paholcsek Melinda 
Published: May 2020

Abstract
Background The effects of nutraceuticals on the modulation of the intestinal microbiota are receiving increased attention however there are scarce number of studies investigating their effects in broiler meat production. The aim of this study was to implement feeding strategies and carry out a comprehensive trial on the interplay between carotenoids, anthocyanins, fructo-oligosaccharides, probiotics and gastrointestinal tract microbiota. Our feeding program was applied on an intensive production system with 1080 broiler Ross 308 flock.Results We observed that nutraceuticals and synbiotics did not affect growth performance remarkably nevertheless, positive correlation was found between body weight and the beneficious Bacteroidales, Corynebacteriales and Pseudomonadales. Nutraceuticals were shown to boost broiler intestinal diversity and differentially enriched Lactobacillus, Enterococcus, Streptococcus and Escherichia-Shigella in core microbiome during the different stages of broiler rearing. Furthermore, diet supplemented with different nutraceuticals was shown to increase the number of unique beneficial bacteria (Faecalibacterium, Akkermansia).Conclusion We concluded that nutraceutical-based feeding strategies can offer a promising, green approach for intensive poultry rearing by improving the health and production of livestock. We believe that the conversion of food industrial waste would result more sustainable bioactive component rich forages which invention could be implemented by other commercial antibiotic-free animal production system providing safe and quality meat.
Prognostic implications of stromal tumor-infiltrating lymphocytes and programmed death ligand 1 expression in HER2-positive invasive breast cancer
Authors: Wang Xinran , Zhang Ningning , LI Shi , Liu Yueping 
Published: May 2020

Abstract
Background: Tumor infiltrating lymphocytes (TILs) are known to be an important prognostic factor of specific breast cancer subtypes. However, to date, PD-L1(SP142)expression and tumor-infiltrating lymphocytes (TILs) has been only minimally reported in HER2-positive breast cancer cases.Methods In this study, CD8,CD4 and PD-L1༈SP142༉ were performed on tissue microarrays (TMA) representing 156 pretreatment cases of HER2-positive invasive breast carcinoma, including 55 hormone receptor (HR)-negative BC patients diagnosed from January 2010 to September 2015.Clinical data were collected, all cases were with complete follow-up data (23 recurrence and 2 deaths). The concordance rate in the tumor immune microenvironment(TIME) classification based on the PD-L1༈SP142༉expression status and CD8/CD4 + TILs count was analyzed.Results PD-L1 expression was identified in 49 cases (31.4%) in immune cells. We found there was no association was found between PD-L1 expression and DFS, but TIME classification was associated with DFS.Conclusion CD4 + and CD8 + lymphocyte infiltration was related to DFS in HER2-positive breast cancer.
Malaria Distribution and Performance of Malaria Diagnostic Methods in Malaysia (1980-2019): A Systematic Review
Authors: Rahim Mohd Amirul Fitri A. , Munajat Bakhtiar , Id Zulkarnain Md 
Published: May 2020

Abstract
Background Malaysia has already achieved remarkable accomplishments in reaching zero indigenous human malaria cases in 2018. Prompt malaria diagnosis, surveillance and treatment played a key role in the country’s elimination success. Looking at the dynamics of malaria distribution during the last decades might provide important information regarding the potential challenges of such an elimination strategy. This study was performed to gather all data available on Plasmodium infections in Malaysia over the last four decades. Methods A systematic review of the published English literature was conducted to identify malaria distribution from 1980 to June 2019 in Malaysia. Two investigators independently extracted data from PubMed, Scopus, Web of Science and Elsevier databases for original papers. Results The review identified 46 epidemiological studies in Malaysia over the 39-year study period, on which sufficient information was available. Majority of studies were conducted in Malaysia Borneo (31/46; 67.4%), followed by Peninsular Malaysia (13/46; 28.3%) and in both areas (2/46; 4.3%). More than half of all studies (28/46; 60.9%) were assessed by both microscopy and PCR, with prevalent by microscopy correlated significantly with prevalent by PCR (R2: 0.7782; P<0.0001). Furthermore, there was a clear trend of decreasing of all human malaria species with increasing P. knowlesi cases throughout the year of sampling period. The summary estimates of sensitivity were higher for P. knowlesi than all human malaria species for both microscopy and PCR. Nevertheless, the specificities of summary estimates were similar for microscopy (40 – 43%) but varied for PCR (2 – 34%). Conclusions This study outlined the epidemiological changes in Plasmodium species distribution in Malaysia. Malaria cases shifted from predominantly caused by human malaria to simian malaria, which accounted for the majority of indigenous cases particularly in Malaysia Borneo. Therefore, malaria case notification and prompt malaria diagnosis in regions where health services are limited in Malaysia should be strengthened and reinforced to achieving the final goal of malaria elimination in the country.