bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upgrading tata kelola keuangan melalui digitalisasi pelaporan keuangan
Authors: Triani Khoiri Indah , Ainy Rintan Nuzul 
Published: December 2024

SP Alumunium adalah salah satu perusahaan manufaktur yang berfokus pada pencetakan dan peleburan alumunium, serta produksi peralatan rumah tangga dan kerajinan tangan. Perusahaan ini sedang menghadapi tantangan yang signifikan terkait dengan pengelolaan keuangan yang masih dilakukan secara manual, yang mengakibatkan rendahnya efisiensi, tingginya potensi kesalahan, dan keterbatasan dalam analisis pelaporan data. Akibatnya proses pencatatan keuangan belum optimal dan memerlukan perbaikan. Untuk mengatasi permasalahan ini, tim pengabdian menyediakan solusi berupa pendampingan dalam memanfaatkan teknologi digital dan pembuatan database berbasis Microsoft Access. Metode Tindakan Partisipatif (PAR) digunakan untuk menarik partisipan untuk bekerja sama, dimana partisipan tidak hanya menjadi sumber informasi, tetapi juga dapat kolaborasi dalam pengelolaan penelitian tindakan Langkah dari pendampingan ini bertujuan untuk mengevaluasi penggunaan pencatatan keuangan digital, pemberian pelatihan, dan peningkatan kemampuan mitra dalam mengelola laporan keuangan secara digital. Kegiatan ini bertujuan untuk mengatasi tantangan pengelolaan keuangan di SP Alumunium dengan memanfaatkan teknologi digital yang telah ada. Dengan memberikan pelatihan dan dukungan dalam penggunaan Microsoft Access kepada mitra SP Alumunium, diharapkan SP Alumunium dapat meningkatkan efisiensi, akurasi, dan kemampuan analisis laporan keuangan, serta mencapai pengelolaan keuangan yang lebih optimal.
The COVID-19 crisis and its initial impacts on emerging countries: an analysis based on the exchange rate pressure index
Authors: Vilela Sampaio Adriano , Andrade Weiss Mauricio , Van Noije Paulo 
Published: December 2024

The objective of this article is to make an empirical characterization of the initial phase of the COVID-19 crisis, which caused greater turbulence on emerging countries, using an exchange rate pressure index that aims to measure the impacts on the exchange rate and international reserves. Conclusions: i) the most acute period of the crisis occurred in March/20, being among the three largest periods of exchange rate pressure since 2003 — behind October/08 and September/11; ii) Algeria, Brazil, Turkey, Pakistan, Nigeria, Angola and South Africa saw the most severe and persistent effects; iii) in most countries, the external adjustment occurred mainly through exchange rate devaluations — the same pattern as the 2008 crisis.
Robust kinetics estimation from kinematics via direct collocation
Authors: Wang Kuan , Zhang Linlin , Liang Leichao , Shao Jiang , Chen Xinpeng , Wang Huihao 
Published: December 2024

IntroductionAccurate joint moment analysis is essential in biomechanics, and the integration of direct collocation with markerless motion capture offers a promising approach for its estimation. However, markerless motion capture can introduce varying degrees of error in tracking trajectories. This study aims to evaluate the effectiveness of the direct collocation method in estimating kinetics when joint trajectory data are impacted by noise.MethodsWe focused on walking and squatting movements as our target activities. To assess the method's robustness, we created five groups with differing noise levels—noise-free, mild noise, noisy group1, noisy group2, and a Gaussian noise group—in the joint center trajectories. Our approach involved combining joint center tracking with biological terms within the direct collocation scheme to address noise-related challenges. We calculated kinematics, joint moments, and ground reaction forces for comparison across the different noise groups.ResultsFor the walking task, the mean absolute errors (MAEs) for the knee flexion moments were 0.103, 0.113, 0.127, 0.129, and 0.116 Nm/kg across the respective noise levels. The corresponding MAEs of the ankle flexion moment were 0.130, 0.133, 0.145, 0.131, and 0.138 Nm/kg. The hip flexion moment had MAEs of 0.182, 0.204, 0.242, 0.246, and 0.249 Nm/kg in the respective groups. In squatting, the MAEs of ankle flexion moments were 0.207, 0.219, 0.217, 0.253, and 0.227 Nm/kg in the noise-free, mild noise, noisy group1, noisy group2, and the Gaussian noise group, respectively. The MAEs of the knee flexion moments were 0.177, 0.196, 0.198, 0.197, and 0.221 Nm/kg, whereas the mean MAEs of the hip flexion moments were 0.125, 0.135, 0.141, 0.161, and 0.178 Nm/kg in the respective groups.ConclusionThe results highlight that the direct collocation method incorporating both tracking and biological terms in the cost function could robustly estimate joint moments during walking and squatting across various noise levels. Currently, this method is better suited to reflect general activity dynamics than subject-specific dynamics in clinical practice. Future research should focus on refining cost functions to achieve an optimal balance between robustness and accuracy.
Toripalimab plus chemotherapy for metastatic muscle-invasive bladder cancer with a high tumor proportion score: a case report
Authors: Ning Wei , Chang Pengkang , Zheng Ji , Chen Wei 
Published: December 2024

BackgroundRadical cystectomy (RC) combined with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive bladder cancer (MIBC). For metastatic MIBC patients, platinum-based chemotherapy remains the first choice treatment. However, approximately 50% of patients with metastatic MIBC are ineligible for platinum-based adjuvant chemotherapy because of impaired renal function. In programmed death ligand 1 (PD-L1)-positive patients who cannot tolerate platinum-based chemotherapy, immunotherapy is recommended. Thus, a major shift is taking place in the treatment of patients with metastatic MIBC. There is currently much interest in the use of chemotherapy combined with immunotherapy and maintenance immunotherapy for the treatment of metastatic MIBC.Case presentationOne patient with metastatic MIBC exhibited promising progression-free survival (PFS) and safety and had good renal function after RC and toripalimab combined with chemotherapy plus toripalimab maintenance therapy.ConclusionRC plus adjuvant therapy (toripalimab combined with chemotherapy) plus toripalimab maintenance therapy is a potential treatment option for metastatic MIBC patients who want to prolong their life. Moreover, a high tumor proportion score (TPS) of PD-L1 expression as well as CDKN2A and TP53 mutation levels may predict immunotherapy efficacy and patient prognosis.
Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study
Authors: Li Hailong , Qiu Jianfeng , Gao Zhe , Li Chun , Chu Jianjun 
Published: December 2024

BackgroundThe link between waist-to-height ratio (WHtR) and osteoporosis (OP) remains a contentious issue in the field of medical research. Currently, the available evidence on this association is deemed insufficient. This topic has garnered significant attention and is a focal point of ongoing investigations.MethodsA retrospective cross-sectional study was conducted, involving 5,746 participants from the National Health and Nutrition Examination Survey. Data on various demographic and clinical parameters, including age, gender, race, poverty income ratio, educational level, smoking status, drinking status, cardiovascular disease, hypertension, diabetes mellitus, hemoglobin A1c, alanine transaminase, aspartate transaminase, serum total bilirubin, serum creatinine, uric acid, blood urea nitrogen, serum sodium, serum phosphorus, total calcium, serum potassium, and serum iron, were collected from all participants. The main analytical methods utilized in this study were multivariable logistic regression, restricted cubic splines, and threshold effect analysis to investigate the association between WHtR and OP.ResultsA total of 5,746 elderly participants were enrolled, with a median age of 69.3 years. Compared with individuals with lower WHtR Q1 (≤0.36 to ≤0.56), the adjusted OR values for WHtR and OP in Q2 (&lt;0.56 to ≤0.61), Q3 (&lt;0.61 to ≤0.66), and Q4 (&lt;0.66 to ≤ 0.94) were 0.63 (95% CI: 0.47–0.85, p = 0.003), 0.53 (95% CI: 0.37–0.76, p &lt; 0.001), and 0.49 (95% CI: 0.35–0.68, p &lt; 0.001), respectively. The association between WHtR and OP exhibited an L-shaped curve (nonlinear, p = 0.008) with an inflection point of roughly 0.57. The OR for the presence of OP was 0.50 (95% CI: 0.31–0.82, p = 0.007) in participants with WHtR &lt;0.57. There was no association between WHtR and OP in participants with WHtR ≥0.57.ConclusionThe association between WHtR and OP showed an L-shaped curve, with an inflection point at around 0.57.
Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China
Authors: Yuan Wenfang , Liu Yongmei , Zhan Haoting , Wei Feng , Zhang Qian , Gao Huixia , Yan Huimin , Huang Tao , Li Yongzhe , Dai Erhei 
Published: December 2024

ObjectiveThe aim of this study was to explore the clinical characteristics of patients infected with different Omicron subvariants presenting non-severe disease, evaluate the safety and efficacy of Azvudine for treatment of COVID-19, in order to broaden understanding of Omicron subvariant infections.MethodA total of 244 individuals with Omicron subvariant (BA.2.76, n = 158; BA.5.1, n = 86) were included in the study. Demographic, clinical, and laboratory data of the study participants were collected and analyzed.ResultPatients infected with BA.5.1 exhibited a higher incidence of clinical symptoms like fatigue (25.58% vs. 2.53%, p &lt; 0.001), headache/dizziness (12.79% vs. 4.43%, p = 0.017), nausea/vomiting (10.47% vs. 1.27%, p = 0.002), viral loads and inflammatory factors, and shorter virus shedding time than those with BA.2.76. There are 28.1% patients reporting mild adverse events following Azvudine administration. After treatment, the levels of anti-SARS-CoV-2 IgG/IgM, white blood cell, and lymphocyte obviously increased, while C-reactive protein, procalcitonin, and D-dimer reduced. Azvudine speeded up the time for virus clearance compared to control treatment (10 vs. 11 days, p = 0.032). Low lymphocyte counts (odd ratio (OR) = 0.607, p = 0.001) and anti-SARS-CoV-2 IgG titer (OR = 0.990, p = 0.028) were the independent risk factors for long nucleic acid negativization duration after infection. Patients with pneumonia were often accompanied by dyspnea, fatigue and high level of D-dimer. Dyspnea (OR = 10.176, p = 0.019) could be used to identify the occurrence of pneumonia in patients infected with Omicron.ConclusionThe study demonstrated the difference in clinical and laboratory parameters between patients infected with Omicron BA.2.76 and BA.5.1, as well as the safety and efficacy of Azvudine therapy. Our study linked patient manifestations to Omicron subvariant, treatment, and clinical outcomes, which is conducive to healthcare providers/policymakers to revise and implement appropriate countermeasures, facilitating appropriately advise for individuals with Omicron subvariant infections.
Clinical utility of synuclein skin biopsy in the diagnosis and evaluation of synucleinopathies
Authors: Isaacson Jonathan R. , Freeman Roy , Gibbons Christopher H. 
Published: December 2024

IntroductionThe diagnosis of diseases known as synucleinopathies, Parkinson’s disease (PD), multiple system atrophy (MSA) and Lewy body dementia (DLB), is predominantly based on clinical criteria. However, diagnostic uncertainty may persist until late in the disease process leading to delays in diagnosis and medical mismanagement. Skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) is a sensitive and specific technique that increases diagnostic sensitivity of synucleinopathies, although the clinical utility of this test has not been fully explored.MethodsTo determine the role of skin biopsy in the diagnosis of synucleinopathies we performed a retrospective chart review of patients who underwent skin biopsy for detection of P-SYN in the evaluation of neurodegenerative disease at a tertiary care academic institution to investigate the change in diagnosis and medical management based on the results of skin biopsy detection of P-SYN.ResultsWe included 97 patients suspected to have a synucleinopathy: 54 with PD, 19 with DLB and 24 with MSA. After skin biopsy testing for P-SYN, 78% of patients had a change in their clinical care with 66% having a change in their diagnosis and 55% having a change in their treatment. Changes in diagnosis were most common in patients with parkinsonism with prominent action tremor (93%), lower-extremity predominant parkinsonism (postural instability and gait dysfunction) (90%), and parkinsonism with predominant cognitive dysfunction (76%).DiscussionIn patients with suspected synucleinopathies, skin biopsy detection of P-SYN had a high level of clinical utility leading to changes in clinical diagnosis and treatment.
Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses
Authors: Liu Tiqian , Yap Adrian Ujin , Sun Yanyu , Zheng Yunhao , Wang Tianqi , Zeng Shiya , Liu Zhen , Xiong Xin 
Published: December 2024

AimThis study aimed to evaluate the factor structure of the Oral Behaviors Checklist (OBC) in Chinese temporomandibular disorder (TMDs) patients and compare the outcomes with those of Western patients. Additionally, it examined the correlations between different OBC subscale scoring methods.MethodsA total of 869 patients completed a survey that included demographic information, the Symptom Questionnaire, and OBC. This was followed by a clinical examination and diagnosis based on the Diagnostic Criteria for TMDs (DC/TMDs). Exploratory factor analysis, along with confirmatory factor analysis, was applied to waking-state oral behaviors, revealing two key factors: Chinese non-functional (C-NFA) and functional (C-FA) oral activities. Items were contrasted with those of Italian TMDs patients (I-NFA and I-FA), and subscale scores were computed, compared, and correlated using Kruskal Wallis and Post-hoc and Spearman’s rank-order correlation (α = 0.05).ResultsVariations in NFA and FA items were observed between Chinese and Italian TMDs patients. For both NFA scoring methods, significant differences were noted between pain-related and intra-articular TMDs. The C-NFA and I-NFA, as well as C-FA and I-FA, scoring methods yielded scores with strong correlations (r &gt; 0.8).ConclusionNFA and FA subscale items were determined for Chinese TMDs patients. Despite item discrepancies, C-NFA and C-FA scores were strongly correlated with I-NFA and I-FA scores, respectively. The OBC can be effectively simplified for use with Chinese TMDs patients. Developing and validating an East–West short-form version of the OBC should be prioritized, given the variations in oral behaviors across countries and cultures.
Low-carbohydrate diet score and chronic obstructive pulmonary disease: a machine learning analysis of NHANES data
Authors: Zhang Xin , Mo Jipeng , Yang Kaiyu , Tan Tiewu , Zhao Cuiping , Qin Hui 
Published: December 2024

BackgroundRecent research has identified the Low-Carbohydrate Diet (LCD) score as a novel biomarker, with studies showing that LCDs can reduce carbon dioxide retention, potentially improving lung function. While the link between the LCD score and chronic obstructive pulmonary disease (COPD) has been explored, its relevance in the US population remains uncertain. This study aims to explore the association between the LCD score and the likelihood of COPD prevalence in this population.MethodsData from 16,030 participants in the National Health and Nutrition Examination Survey (NHANES) collected between 2007 and 2023 were analyzed to examine the relationship between LCD score and COPD. Propensity score matching (PSM) was employed to reduce baseline bias. Weighted multivariable logistic regression models were applied, and restricted cubic spline (RCS) regression was used to explore possible nonlinear relationships. Subgroup analyses were performed to evaluate the robustness of the results. Additionally, we employed eight machine learning methods—Boost Tree, Decision Tree, Logistic Regression, MLP, Naive Bayes, KNN, Random Forest, and SVM RBF—to build predictive models and evaluate their performance. Based on the best-performing model, we further examined variable importance and model accuracy.ResultsUpon controlling for variables, the LCD score demonstrated a strong correlation with the odds of COPD prevalence. In compared to the lowest quartile, the adjusted odds ratios (ORs) for the high quartile were 0.77 (95% CI: 0.63, 0.95), 0.74 (95% CI: 0.59, 0.93), and 0.61 (95% CI: 0.48, 0.78). RCS analysis demonstrated a linear inverse relationship between the LCD score and the odds of COPD prevalence. Furthermore, the random forest model exhibited robust predictive efficacy, with an area under the curve (AUC) of 71.6%.ConclusionOur study of American adults indicates that adherence to the LCD may be linked to lower odds of COPD prevalence. These findings underscore the important role of the LCD score as a tool for enhancing COPD prevention efforts within the general population. Nonetheless, additional prospective cohort studies are required to assess and validate these results.
Clinical practice guidelines for the treatment of squamous cell carcinoma of the head and neck: an assessment based on the AGREE II, AGREE-REX tools and the RIGHT checklist
Authors: Zhang Yingzhen , Liu Junjie , Liu Shuyu , Zhang Ying , Su Xingzhou , Huang Shaohui , Duan Weiyi 
Published: December 2024

ObjectiveThe aim of this study was to obtain several published clinical practice guidelines (CPGs) for Head and neck squamous cell carcinoma (HNSCC) and critically assess and compare their quality by using three guideline quality evaluation tools, namely, AGREE II, AGREE-REX, and RIGHT, to support the development of future CPGs for HNSCC.MethodsClinical practice guidelines related to the diagnosis and treatment of HNSCC were screened through a comprehensive systematic literature search. Data were extracted from the guidelines which met the inclusion criteria, and two experienced head and neck oncology surgeons were trained to act as independent reviewers. The quality of the retrieved guidelines that met the inclusion and exclusion criteria was evaluated by using the AGREE II, AGREE-REX, and RIGHT tools. Then, the quality of the guidelines that met the criteria was assessed. Finally, conclusions and recommendations were drawn based on the scoring results.ResultsA total of eight guidelines met the inclusion criteria. Four guidelines(written by ASCO, NCCN, CCO and KCE) scored &gt; 60% in five or more AGREE II quality domains, two guidelines(written by ASCO and KCE) scored &gt; 60% in all AGREE-REX quality domains, and two guidelines(written by ASCO and KCE) scored &gt; 60% in all quality domains on the RIGHT checklist and were considered “recommendable”.ConclusionsThe authors recommend consulting the American Society of Clinical Oncology guidelines for HNSCC and suggest that future guideline development groups refer to the guideline evaluation framework for guideline writing to enhance the applicability and effectiveness of clinical practice guidelines.
Polysaccharides derived from golden mushroom (Cantharellus cibarius Fr.) modulate gut microbiota and enhance intestinal barrier function to ameliorate dextran sulfate sodium-induced colitis in mice
Authors: Alioui Yamina , Ullah Hidayat , Ali Sharafat , Rahman Mujeeb Ur , Elkharti Maroua , Farooqui Nabeel Ahmed , Rehman Ata Ur , Ilyas Muhammad , Alsholi Duaa M. , Siddiqi Nimra Zafar , Ali Muhsin , Wang Liang , Xin Yi 
Published: December 2024

IntroductionInflammatory bowel disease (IBD), including ulcerative colitis, is marked by intestinal barrier disruptions, immune system dysregulation, and an imbalance in the gut microbiota. The golden chanterelle mushroom, Cantharellus cibarius Fr., a popular edible mushroom, has shown potential therapeutic benefits. This study examines the therapeutic potential of a crude polysaccharide extract obtained from C. cibarius Fr. (CCP) on intestinal barrier integrity, inflammatory cytokine levels, and gut microbiota composition in a murine model of colitis induced by dextran sulfate sodium (DSS).MethodsTo induce colitis BALB/c mice were provided to consume autoclaved water with 3% DSS for 7 days, followed by 14 days of CCP supplementation. To assess the effects of CCP, histological analysis of colon tissue was performed, gene expression, inflammatory responses, tight junction proteins expression, gut barrier integrity, and cytokines levels were measured and analyzed and 16S rRNA sequencing were evaluated.Results and DiscussionCCP treatment alleviates colitis symptoms by improving body weight, and enhancing intestinal integrity through increased mucin-2 and tight junction protein expression. Additionally, CCP administration regulates the altered immune response by mitigating the expression of pro-inflammatory cytokines and upregulating anti-inflammatory cytokines. Furthermore, CCP supplementation effectively modulates DSS-induced dysbiosis as demonstrated by 16S rRNA sequencing results. These findings suggest that crude polysaccharides from the golden chanterelle mushroom, C. cibarius Fr., hold promise for treating colitis, via strengthening the intestinal barrier, regulating inflammatory responses, and reshaping the gut dysbiosis in a DSS-induced colitis model. CCP offers a novel approach for managing colitis, as a chronic inflammatory condition.
The effect of adult attachment on mobile phone dependence among university students: the mediating role of loneliness
Authors: Wang Zhenhong , Xuan Bin 
Published: December 2024

ObjectiveThis study aimed to examine the direct relationship between adult attachment and mobile phone dependence, as well as the mediating role of loneliness.MethodsUsing a cross-sectional study design, 596 Chinese university students (mean age = 19.8, SD = 1.09; females = 309) completed the Experience in Close Relationship Inventory, the UCLA Loneliness Scale, and the Mobile Phone Addiction Index.ResultsThere were significant differences in loneliness and mobile phone dependence among university students with different adult attachment types. Adult attachment was found to have a significant positive correlation with mobile phone dependence. Moreover, adult attachment had an indirect association with mobile phone dependence through the mediating role of loneliness.ConclusionAdult attachment and mobile phone dependence are closely related, and loneliness plays a vital role in this relationship, suggesting that mobile phone dependence can be reduced by alleviating university students’ loneliness. These findings enhanced the understanding of the mechanism of mobile phone dependence and provided new perspectives for the prevention and treatment of mobile phone dependence among university students.