bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of cows treatment with purulent pododermatitis complicated by keratomycetes
Authors: Khomyn N. M. , Mysak A. R. , Tsisinska S. V. , Pritsak V. V. , Nazaruk N. V. , Lenjo Yu. M. 
Published: November 2020

One of the main branches of agricultural production in Ukraine was and remains animal husbandry. Under modern conditions of cattle breeding, the hooves of cows deserve special attention of a veterinarian, which are often exposed to various adverse factors, which, for the most part, leads to the development of inflammatory processes in the area of the base of the sole skin, sometimes of septic genesis complicated by keratomycetes. It is known that for the treatment of orthopedically ill animals there is enough wide arsenal of medicinal substances and developed methods of therapy, however, most of the proposed means exhibit only antibacterial properties, act in the lesions superficially, poorly penetrate into the depths of the tissues and do not always give the desired result. Therefore, the aim of the work was to develop an effective method of treatment of such animals with the use of medicinal substances with a wide range of antibacterial, antimycotic action, which have the ability to penetrate into tissues and promote their regeneration. For research, two groups of cows were formed, 5 animals in each, selected on the principle of analogues in terms of the nature and location of the pathological process. For therapeutic purposes, the cows of both groups after anesthesia were corrective clearing, formed a funnel-shaped hole in the area of purulent pododermatitis and irrigated with 10 % hypertonic sodium chloride solution. On the affected area, the animals of the control group was applied a finely grated (separately) mixture of potassium permanganate and boric acid, and the control – a mixture of nanoclusters of aquachelates Ag, Cu, Zn, impregnated with a cotton swab and pantevenoli. A bandage and a protective cover were applied to the affected hooves of animals of both groups. It is defined that the proposed method of treatment makes it possible to promote the recovery of animals and reduce the treatment period by 6 days, confirmed by the results of clinical, biochemical, bacteriological, mycological and statistical studies.
Clinical and cost-effectiveness analysis of the methods of therapy and prevention of andrological pathologies using drugs based on ozone and nano-biomaterials
Authors: Naumenko S. V. 
Published: November 2020

Practical implementation of the latest pharmacological developments is possible provided that their clinical and economic efficiency is assessed. At the same time, the issues of economic feasibility of using the latest diagnostic techniques, as well as means of therapy and prevention of the male reproductive pathologies system remain poorly studied. The aim of the work was to analyze the cost-effectiveness of methods of therapy and prevention of andrological diseases with drugs based on ozonated and nanobiomaterials. The following research tasks were set: to establish the clinical and economic effectiveness of the method of therapy of males for nonspecific balanoposthitis with ozone-containing drugs OCO and Prozon and to determine the economic effect of treatment and prevention methods of alimentary and toxic reproductive diseases in males using drugs based on nanobiomatersals. Clinical and economic efficacy of the treatment method of males with nonspecific balanoposthitis was established by estimating the cost of treatment of animals group with OCO and Prozon by changes in the diseaseduration from treatment to recovery of the fetus compared with conventional antibiotic therapy. The economic effect of therapy and prevention methodsof alimentary and toxic reproductive diseases was evaluated by changes in sperm quality and calculated the average number of additional sperm doses received from the males. The duration of the period from the beginning of treatment to recovery in boars with the use of ozone-containing drugs was: when using OKO – 6.7 ± 0.18 days, and Prozon – 6.1 ± 0.21 days, which was less by 0.9–1.5 days compared with the introduction of gentamicin ointment. And in bulls when using the drug OKO – by 6.7 ± 0.33 days, and Prozon – 5.14 ± 0.26 days, which was less by 1.1–2.7 days. At the same time, the cost of treatment of one male has decreased by 42.3 % with the use of OKO and 37.5 % – Prozon. Despite the higher cost of the drug Prozon, its use is more effective due to faster recovery of the malts. An increase in ejaculate volume, sperm motility, concentration based on the results of correction of alimentary and toxic reproductive diseases has been established; the number of sperm with morphological abnormalities, on the other side, was probably reduced. The complex drug “Karafand+OV,Zn” had a high economic effect due to the possibility of additional receipt 6 spermodoses from the boar and 22 from the bull for the correction of reproductive diseases of the alimentary type and 6 spermodoses from the boar and 20 from the bull – toxic type.
Pathomorphological characteristics of viral hemorrhagic disease of rabbits
Authors: Zaika S. S. , Bezdіtko L. V. , Guralska S. V. , Kot T. F. , Khomenko Z. V. 
Published: November 2020

The dead animals have a pathomorphological picture with a brightly expressed hemorrhagic diathesis, in many organs there is venous stasis. Blood does not clot for several hours, and at autopsy of organs (heart, lungs, liver, kidneys) it is poured in significant amounts into the body cavity. Macroscopically, the most significant changes are observed in the respiratory system. The lungs are blood-filled, intensely swollen and unevenly colored, have a grayish-pink color with single or multiple spotted and spotted hemorrhages under the pleura. Red or almost colorless liquid flows down from the incision surface, foamy exudate is released from the bronchi when pressed on. There are no patterns in the localization of pathomorphological changes in any part of the lungs (apical, cardiac, diaphragmatic): all parts are damaged at once, or mainly in one or another part. The walls of the trachea, nasal cavities, to a lesser extent the larynx are distinctly hemorrhagic. Their red color is more often caused by venous hyperemia. The lumen of the trachea and larynx is filled with red or colorless foamy fluid. Changes in the liver are constant, but not always the same type and are due to the degree of its blood supply, which causes a change in color, amount and consistency. In the first hours after the death of the animal, the liver is usually completely blood-filled, enlarged, easily torn, has a reddish-brown color with a yellowish tinge in the central parts of the lobes. The capillary network of the body looks like red streaks and dots of irregular shape. Spotted hemorrhages are sometimes observed under the capsule of the organ. The gallbladder contains some bile, its mucous is rough, a bit exfoliated. The spleen is increased in size by 1.5–3 times, swollen, dark cherry in color with a typical purple tinge. The kidneys are completely blood-filled, reddish-brown and increased in several times. The thymus is slightly reddened, often with multiple spotted or spotted hemorrhages in the chest. Lymph nodes are pulpy, grayish-pink, rarely red, not significantly changed in size. The heart (especially its right half) is filled with a large amount of black and red blood, increased in size , the walls of the ventricles are stretched, thin, have flabby consistency. Multiple spotted and spotted hemorrhages under the epicardium and endocardium are common. Changes in the gastrointestinal tract characterize catarrhal (rarely catarrhal-hemorrhagic) inflammation, sometimes hemorrhage in the duodenum and rectum, exfoliation of the gastric mucosa. In the form of hemorrhage, pathological and anatomical changes are found in the uterus and adrenal glands, in the form of congestive hyperemia – in the genitals, goiter, brain.
Dynamics of morphological and biochemical parameters in the blood of white mice under the action of the drug “Vitosept”
Authors: Soltys M. P. , Gunchak V. M. , Rudyk H. V. , Vasiv R. O. 
Published: November 2020

The paper presents the results of the study of the drug toxicity “Vitosept” in its preclinical studies in intact white mice. It was found that according to the assessment of toxicological parameters of the studied biocidal product is low-toxic. Oral administration of even its highest concentrations (500 mg/l) did not show a pronounced toxic effect. During the action of the drug for 20 days no deviations in the clinical condition, behavioral reactions, reflex activity did not occur. It was found that most of the values that characterize the functional state of the hematopoietic and hepatobiliary systems, against the background of different concentrations of sodium hypochlorite, did not undergo significant changes compared with the control. The hemoglobin content in the blood of white mice in the experimental groups increased compared with the control in the first three experimental groups (concentration of GHN 100–300 mg/l). With increasing concentration of the drug, when administered intraperitoneally, there was a greater number of leukocytes in the blood of laboratory animals. At the same time, a probable increase in this indicator was found only in mice of the II experimental group when administered orally to animals of the lowest test concentration (100 mg/l). The concentration of total protein, urea and glucose in the blood of white mice under the action of “Vitosept” was similar in animals of the control and experimental groups. The revealed tendency to increase the activity of certain enzymes (LF, ALT, AST) was short-lived, and is obviously a compensatory response of animals to the xenobiotic effect of the drug. On the 20th day of the experiment, the studied white mice of the experimental groups were close to those in the control group.
Influence of the 3D Printing Process Settings on Tensile Strength of PLA and HT-PLA
Authors: Hanon Muammel M. , Marczis Róbert , Zsidai László 
Published: November 2020

Fused Deposition Modelling (FDM) is presently the most common utilized 3D printing technology. Since this printing technology makes the bodies anisotropic, therefore, investigate the process with different settings is worthwhile. Tensile test specimens of two plastics have been carried out to examine the mechanical properties. Polylactic acid (PLA) and High Temperature PLA (HT-PLA) are the used materials for this purpose. A total of seventy-two test pieces of the two used polymers were printed and evaluated. Three parameters were examined in twelve different settings when printing the tensile test specimens. The considered settings are; six raster directions, three build orientations and two filling factors. The differences in stress-strain curves, tensile strength values and elongation at break were compared among the tested samples. The broken specimens after the tensile test are illustrated, which gave insight into how the test pieces printed with different parameters were fractured. The optimum printing setting is represented at crossed 45/−45° raster direction, X orientation and 100 % fill factor, where the highest tensile strength of 59.7 MPa at HT-PLA and the largest elongation of about 3.5 % at PLA were measured.
Microbiological Estimation of Nasal Spray Containing Naltrexone Hydrochloride
Authors: Domnina Yu. M. , Suslov V. V. , Grammatikova N. E. , Kedik S. A. 
Published: November 2020

Introduction. In order to standardize the quality indicators during the expected shelf life of the developed drug naltrexone hydrochloride in the form of a nasal spray containing a high concentration of poloxamer and benzalkonium chloride as a preservative, a microbiological study was carried out. The possibility of using the membrane filtration method for testing prototypes recommended by the State Pharmacopoeia XIV.Aim. Study and selection of test conditions for the «microbiological purity» indicator of nasal spray samples containing naltrexone hydrochloride.Materials and methods. As an object of research, a naltrexone hydrochloride nasal spray was used. When analyzing the microbiological purity, the membrane filtration method recommended in the State Pharmacopoeia XIV.Results and discussion. As part of the study, it was found that the samples of the drug meet the requirements for a microbiological indicator for drugs of category 2. Testing the suitability of the method for samples of the dosage form showed that the antimicrobial effect of the drug was completely removed by washing the filter, which was proved by inoculation of indicator test microorganisms, the quantitative and qualitative nature of growth, which did not differ from the control without the drug.Conclusion. As a result of the studies carried out, the optimal test conditions for the «Microbiological purity» indicator for the nasal spray containing naltrexone hydrochloride were selected and substantiated.
Indolo[2,3-a]carbazole Derivatives with Antitumor Activity and Instrumental Methods for Their Investigation (Review)
Authors: Kozin D. A. , Shprakh Z. S. , Reshetnyak V. Yu. , Nesterova O. V. , Avertseva I. N. , Rodionova G. M. 
Published: November 2020

Introduction. Currently, more than 600 thousand people a year are affected by malignant tumors on the territory of the Russian Federation. Despite the large selection of antitumor drugs and the variety of mechanisms of their action, the effectiveness of existing drugs continues to be insufficient. The main disadvantages of most antitumor drugs are the emergence of tolerance to them of tumor cells, a limited range of action and high toxicity. In this regard, the creation of effective original domestic antitumor drugs still remains relevant. Among the numerous natural and synthetic heterocyclic compounds that exhibit antitumor activity, indolo[2,3-a]carbazole derivatives that can initiate various pathways of tumor cell death are of increasing interest. The main targets for their action are topoisomerases and protein kinases, which play an important role in the processes of replication, transcription, repair or recombination of deoxyribonucleic acid (DNA). Due to this, in addition to antitumor activity, this group of compounds shows antibacterial, аntiprotozoal and immunomodulatory activity, which makes them a very promising class of candidates for the creation of new drugs.Text. The purpose of this review is to discuss instrumental methods for qualitative and quantitative analysis of indolo[2,3-a]carbazole derivatives used in the world's leading pharmacopoeias. These methods can be used both in pharmacokinetic studies, and in the standardization of these compounds, in the form of pharmaceutical substances, or as part of drug forms.Conclusion. To further introduce a new group of antitumor drugs based on indole[2,3-a]carbazole derivatives into medical practice, a deep and thorough study of their physical and chemical properties is necessary. Justification and development of analysis methods allow us to develop methods applicable to pharmacokinetic studies, as well as to create regulatory documents for quality control and standardization of indolo[2,3-a] carbazole derivatives as pharmaceutical substances. A study of the literature that describes methods for analyzing indolo[2,3-a]carbazole derivatives indicates that spectrometric (infrared and ultraviolet spectrometry) and chromatographic (thin-layer chromatography and high-performance liquid chromatography) methods are most often used to determine the authenticity and quantitative analysis of these compounds.
New Approach to Drug Delivery in Ophthalmological Practice: Development of Composite Ophthalmological Solution for Drug Loading of Soft Contact Lenses
Authors: Naplekov D. K. , Zhilyakova E. T. , Malyutina A. Yu. , Bondarev A. V. , Demina N. B. , Novikov O. O. , Abramovich R. A. 
Published: November 2020

Introduction. This article provides a tentative justification of use of soft contact lenses as a carrier of ophthalmological solutions to eye tissues.Aim. The aim of the research is to develop the composition of the ophthalmic transport system for the treatment of glaucoma. Also, the proposed manufacturing algorithms were proposed for drug loading ophthalmological solutions.Materials and methods. Preparation of sodium hyaluronate solution was carried out based on the methodology described in EP 7.0 [01/2011:1472] (Sodium hyaluronate).Results and discussion. The conducted investigation with the purpose to justify a concentration of sodium hyaluronate helped to determine its concentration that gives the viscosity level as close to the upper limit stated in Russian Pharmacopoeia as possible. Buffer solution was chosen with criteria to use as less components in ophthalmological solution as possible. Also, it was found out that the more components are added to the viscous solution, the more viscosity level is decreased. Thus, initial viscosity of solution containing sodium hyaluronate was 149.59 mm2/s, and after addition of active pharmaceutical substance it dropped down to 88.49 mm2/s and 81.36 mm2/s for model solution number 1 and 2, respectively. After addition of citric acid and disodium hydrophosphate, the viscosity of model solution was found to be 78.11 mm2/s and 75.28 mm2/s for model solution number 1 and 2, respectively.Conclusion. As a result of the studies, two alternative model compositions of an ophthalmic solution for the saturation of soft contact lenses for the treatment of glaucoma were proposed. The choice of active pharmaceutical substances, and excipients has been justified. Technological procedure of preparation of model solution was described and explained, where the most attention was paid on dissolving of sodium hyaluronate in purified water.
De braços vazios, nos braços da dor: Perda gestacional e neonatal
Authors: Alves Rayssa Stéfani Sousa , Celestino Kênia Alessandra de Araújo 
Published: November 2020

O objetivo deste estudo consiste em identificar os sentimentos e as reações da mulher frente ao processo de luto gestacional e neonatal. E compreender qual a percepção da mulher quanto ao seu papel biológico e conjugal após a perda do filho. Trata-se de uma revisão integrativa de literatura, com abordagem qualitativa, realizada por meio da busca de artigos indexados na Biblioteca Virtual em Saúde (BVS), com o auxílio das seguintes bases de dados: Scientific Electronic Library Online (SCIELO), National Center for Biotechnology Information (PUBMED), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de Dados de Enfermagem (BDENF), e Periódicos Eletrônicos em Psicologia (PEPSIC). Os critérios de inclusão compreendem pesquisas entre os anos de 2004 a 2020. Como critérios de exclusão, não foram considerados artigos mediante a recompensação monetária, incompletos e não convergentes com este estudo. Para o levantamento dos dados e composição deste estudo, foram analisados 10 artigos. Os resultados evidenciam os sentimentos perturbadores mais frequentes de mulheres frente ao processo de luto. A gestação representa a concretização de um sonho para a mulher, sonho que transforma-se em pesadelo quando a gravidez não avança. Concluímos que, a perda gestacional ou neonatal é um dos lutos mais complexos e de menor validação social. Estamos falando que, em um momento de vida há morte. A incontinuidade da vida fica escancarada, nenhuma mulher que engravida, está psicologicamente preparada para sofrer uma perda, seja ela de que natureza for, constituindo um período de crise, gerador de grande sofrimento e dificuldades adaptativas.
Heart Rate Reactivity to Mental Stress in Athlete and Non-Athlete Children
Authors: Ábel Krisztina , Szabó Attila Rausz , Szabo Attila 
Published: November 2020

Background. Research suggests that exercise training and/or physical fitness may be associated with lower heart rate reactivity and faster recovery from psychosocial stress. This relationship was rarely studied in children despite the potential protective role of physical activity in stress that may start in early life stages.
Methods. In this laboratory investigation we examined 18 athlete and non-athlete children before, during and following exposure to mental stress which consisted of the Stroop Color Word Task and a mental arithmetic task, both distracted by classical music, in a counterbalanced research design.
Results. The results based on absolute heart rate measures suggested that athletes exhibited lower heart rates in the stress-anticipation period as well as during the stress period than non-athletes. However, based on relative measures these differences vanished. The two groups of children did not differ in perceived arousal, perceived stressfulness of the mental tasks, and the self-reported feeling states before and after stress. Further, they did not differ in their performance on the two stress-eliciting active-coping tasks as indicated by the number of correct answers.
Conclusion. These results appear to suggest that athletic status in children is unrelated to heart rate reactivity and other subjective psychological experiences before, during and after acute psychosocial stress.
Keywords: adolescent, exercise, fitness, physical activity, relative measures.
The Benefit Assessment of the Physiotherapy Sessions for Children with Autism Spectrum Disorder
Authors: Draudvilienė Lina , Sosunkevič Sergej , Daniusevičiūtė-Brazaitė Laura , Burkauskienė Aušra , Draudvila Justas 
Published: November 2020

Background. Children with autism disorder show atypical preference for non-social stimuli. Therefore, the deficits of social communication and social interest are primary and usually named features for the Autism Spectrum Disorder (ASD). The main idea of the present work was to show that the physiotherapy sessions (PS) were some of the ways that could improve the physical condition of children with ADS. Moreover, the application of such programs increased self-esteem, communication skills and permitted a better adaptation and integration within society.
Methods. Eleven children attending kindergarten for children with special needs participated in this investigation. The inclusion criteria were a clinical diagnosis of ASD. All participants had F 84.0 code in their cases and were specified for grade II autism disorder according to the American Psychiatric Association (2014). The investigation process consisted of four stages: the initial testing, the application of the physiotherapy program (PS), the post-application testing and the analysis, interpretation and comparison of obtained results. The investigation process was applied for six weeks.
Results. After PS applications, the children’s balance improved by 21.32%, coordination – 23.36%, physical and functional abilities such as speed (13.18%) and explosive leg strength (37.14%).
Conclusions. The physiotherapy sessions improved the physical condition of children with ADS: balance, coordination, functional abilities and the explosive leg strength. The capability to do physical exercises in a group, at home or in individual sessions with specialist improved as well.
Keywords: pre-school children, individual physiotherapy program, social skills.