bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of cardioprotective diseases bioactive components from Danshen extracts and LC–MS analysis
Authors: Yuan Jiang‐Feng , Hu Jin‐Wan , Chen Zhuo‐Yao , Wang Da‐Hong 
Published: March 2020

AbstractA rapid and efficient analysis and screening method is adopted for cell affinity capture coupled with HPLC–MS (CAC–HPLC–MS) analysis of bioactive components that have possible efficiency against cardiovascular diseases. This method involves affinity capture, concentration, and separation of bioactive components from Danshen library using oxidatively damaged endothelial cells induced by H2O2, as well as analysis and identification of targeted compounds with HPLC and MS. It combines the specific interaction between cell membrane receptors and bioactive components with the powerful analysis and identification function of HPLC–MS. The CAC–HPLC–MS method was also used for analysis and screening of bioactive components from crude extracts of Danshen. A total of 19 components were found to be bound to oxidatively damaged endothelial cells with seven of these identified. Existing literature confirms that these seven components have many activities related to cardioprotective diseases. Therefore, the combination of biological affinity capture with HPLC–MS should be regarded as an attractive method with great potential for rapid and efficient screening of bioactive components related to anti‐cardiovascular diseases from natural product libraries.
Prognostic significance of the radiologic features of pneumonitis induced by anti‐PD‐1 therapy
Authors: Watanabe Satoshi , Ota Takeshi , Hayashi Masachika , Ishikawa Hiroyuki , Otsubo Aya , Shoji Satoshi , Nozaki Koichiro , Ichikawa Kosuke , Kondo Rie , Miyabayashi Takao , Miura Satoru , Tanaka Hiroshi , Abe Tetsuya , Okajima Masaaki , Terada Masaki , Ishida Takashi , Iwashima Akira , Sato Kazuhiro , Yoshizawa Hirohisa , Kikuchi Toshiaki 
Published: March 2020

AbstractBackgroundInterstitial lung disease (ILD) induced by anti‐programmed‐cell death‐1 (PD‐1) and anti‐PD‐ligand 1 (PD‐L1) is potentially life‐threatening and is a common reason of the discontinuation of therapy. In contrast, an enhancement in antitumor effects was reported in patients who developed immune‐related adverse events, including ILD. Although recent evidence suggests that radiologic patterns of ILD may reflect the severity of ILD and the antitumor immune responses to anti‐PD‐1/PD‐L1 therapies, the association between radiologic features and clinical outcomes remains unclear.MethodsPatients with advanced non‐small‐cell lung cancer who were treated with 1st to 3rd line anti‐PD‐1 therapy from January 2016 through October 2017 were identified at multiple institutions belonging to the Niigata Lung Cancer Treatment Group. ILD was diagnosed by the treating physicians, and chest computed tomography scans were independently reviewed to assess the radiologic features of ILD.ResultsA total of 231 patients who received anti‐PD‐1 therapy were enrolled. Thirty‐one patients (14%) developed ILD. Sixteen patients were classified as having ground glass opacities (GGO), 16 were classified as having cryptogenic organizing pneumonia (COP), and one was classified as having pneumonitis not otherwise specified. Patients with GGO had significantly worse overall survival time compared to patients with COP (7.8 months (95% CI: 2.2‐NE) versus not reached (95% CI: 13.2‐NE); P = 0.0175). Multivariate analysis of all 231 patients also revealed that PS = 1 and ≥2 and GGO were significant predictors of a worse overall survival.ConclusionsThis study demonstrated that patients who developed GGO exhibited worse outcomes among non‐small‐cell lung cancer patients receiving anti‐PD‐1 therapies.
Surface‐Functionalized Graphite as Long Cycle Life Anode Materials for Lithium‐Ion Batteries
Authors: Gong Xiaohui , Zheng Yuanbo , Zheng Jiang , Cao Shengping , Wen Hui , Lin Baoping , Sun Yueming 
Published: March 2020

AbstractGraphite is the major anode material of commercial lithium‐ion batteries (LIBs), and thus improving its cycling stability is an effective approach to extend battery life. In this study, succinic anhydride group, methoxyethanol, and methoxypolyethylene glycol segments are chemically bonded to the surfaces of graphite particles by the Diels‐Alder and the subsequent esterification reactions. The synthesized functionalized graphites are excellent in water dispersibility. The electrochemical results indicate that the functionalization slightly reduces the initial coulombic efficiencies of the graphite anodes, but significantly changes the cycling stability and high C‐rate performance of the corresponding lithium‐ion cells. In particular, the cell based on the graphite functionalized by long‐chain polyethylene glycol exhibits an improvement of 24.1 % in cycle life compared with the pristine graphite. Further analysis shows that these trace organic groups change the properties of the solid‐electrolyte interface (SEI) layer depositing on the graphite surfaces, and therefore influence the performance of the cells.
Influence of the NaOH Concentration on the Hydrogen Electrode Reaction Kinetics of Ni and NiCu Electrodes
Authors: Kuznetsov Aleksey N. , Oshchepkov Alexandr G. , Cherstiouk Olga V. , Simonov Pavel A. , Nazmutdinov Renat R. , Savinova Elena R. , Bonnefont Antoine 
Published: March 2020

AbstractNickel is a promising electrocatalyst for hydrogen electrode reactions in alkaline media. Its electrocatalytic activity for hydrogen oxidation and evolution reactions can be enhanced when its surface is partially covered by Ni (hydr)oxides or by associating it with Cu. In this work, the influence of the NaOH concentration on the hydrogen electrode kinetics on various Ni electrodes is investigated. On metallic Ni, the electrocatalytic activity (measured as an exchange current density normalized to the surface area of Ni) is almost constant between pH 12 and 14, whereas it decreases by a factor of two on partially oxidized Ni and on the NiCu/C electrode. Analyzing the current potential curves with the help of microkinetic modeling reveals that the Had and OHad binding energies on Ni do not depend on pH, whereas the rate constants of the Volmer and Heyrovsky reactions decrease with pH. The pH effect on the electron transfer elementary act is briefly discussed in the framework of a quantum mechanical theory.
EXPANSION OF CRÉTEIL SOLEIL SHOPPING CENTRE IN PARIS: DESIGN AND CONSTRUCTION OF STEEL AND COMPOSITE STRUCTURES
Authors: Augusto Hugo , Ribeiro César , Valério David , Ferreira Tiago , Pereira Marco , Gomes Filipe 
Published: March 2020

AbstractThe expansion of one of the largest shopping centres in France created the opportunity to develop solutions for large span floors and roofs, using steel and composite structures. Among the structures analysed the following are highlighted: the structure for the Mail area (food court) with welded I section beams with a height of 1.5m and 25m of span. And, the designated “Toiture Jonction”, which comprises two major beams with a span of about 30m, also made with welded I sections of 2.4m height. The several phases and challenges inherent to the design, manufacture and assembly will be addressed, from the technical point of view, supported in the value engineering involved, and the main steps to be considered to embrace a project of this nature are enumerated.
EXPERIMENTAL AND NUMERICAL INVESTIGATION ON THE STEEL BOX‐GIRDER BRIDGE DECKS WITH CURVED BOTTOM FLANGE
Authors: Ljubinković Filip , Pedro Martins João , Gervásio Helena , Simões da Silva Luís 
Published: March 2020

AbstractIn this paper, the results of the numerical parametric study are presented, in which the M‐V interaction behaviour of box‐girder bridge deck specimens was investigated. For this study, an advanced numerical model was used, previously calibrated against the experimental results. Based on the numerical results and the existent rules for the trapezoidal box‐girders, new design models were proposed for the prediction of the bending and shear resistance of cross‐sections with the curved bottom flange. Additionally, the force‐based M‐V interaction equation proposed by Jáger et al. [1] that is also adopted in the new version of EN 1993‐1‐5 [2] is verified and slightly modified to fit for this type of the cross‐section.
New Bridge Over Shire River, Malawi
Authors: Mendonça Tiago , Almeida Manuel , Rodrigues Bruno 
Published: March 2020

AbstractThis communication describes the major aspects concerning the design and construction of the new railway bridge over the Shire river, located on pk 275+133 of Limbe‐Nkaya railway line, in Malawi. This railway line makes the connection between Nkaya Junction and Limbe, in Blantyre and is used both for passengers and cargo.The existing bridge has an advanced state of materials deterioration, resulting from maintenance difficulties, wear due to its exploration and high susceptibility to erosion phenomena. The cost‐benefit of an existing bridge rehabilitation intervention was quite unfavourable and the option for new bridge was found preferable.
EXPERIMENTAL STUDY ON DEEP‐COLUMN SUBJECT TO COMPRESSIVE AXIAL FORCE WITH ONE END CYCLIC BENDING MOMENT
Authors: Yoshioka Shimpei , Sato Atsushi , Onogi Takeshi 
Published: March 2020

AbstractThe design formulae of beam‐column are provided by Recommendation for Limit State Design of Steel Structures (LSD) in Japan. The design recommendation shown in LSD is derived from the test results that are basically obtained from one end monotonic bending moment. Therefore, it is necessary to examine whether these formulae can appropriately evaluate the strength of the beam‐column under cyclic loading condition. In this paper, the test results of the deep‐column are reported. The dimensions of the specimens were determined per LSD. Deep wide‐flange section H‐150×75×5×7 (unit: mm) is used for the specimen. From the testing, a few unconservative results were observed in LSD design formulae.
PARAMETRIC STUDY OF THE CURVED T‐STUB IN TENSION
Authors: Mudrov Andrej , Šapalas Antanas , Šaučiuvėnas Gintas 
Published: March 2020

AbstractThis paper presents parametric study of the T‐stubs with curved end‐plates in tension. Influence of the key parameters such as curvature, bolt arrangement and the thickness of the end‐plate on the strength and stiffness of the T‐stub is investigated. In curved T‐stubs bolts not only undergo tension, but are also subjected to shear, which limits the use of the conventional prying models. Apart shear, due to curvature, determination of the total effective length of a T‐stub is not trivial, and the collapse mechanisms of the end‐plate are uncertain. To clarify behaviour of the curved T‐stub and to determine the influence of the curvature on prying and shear, FEM results of 108 T‐stubs were analysed.
NUMERICAL EVALUATION OF DUPLEX STAINLESS STEEL STAYED COLUMNS
Authors: Ribeiro Danielle M. , da S. Vellasco Pedro C. G. , de Lima Luciano R. O. , de Araújo Ricardo R. , da Silva André T. 
Published: March 2020

AbstractThe use of prestressed stayed steel column systems in construction has numerous advantages related to its high strength and assembly flexibility. The present work aims to present an investigation of the structural behaviour of duplex stainless steel columns through a numerical modelling, using the finite element method, through the ANSYS program. The results confirmed that the use of cable prestress significantly increases the ultimate loads and ductility of the system, indicating the potential of these efficient and promising solutions. This was mainly due to their considerable resistance gain and numerous advantages in replacing carbon by stainless steel.
STRUCTURAL BEHAVIOUR OF JOINT BETWEEN STEEL BEAM AND CONCRETE ENCASED STEEL COMPOSITE COLUMN
Authors: Arita Masaki , Kitaoka Satoshi , Kanno Ryoichi , Nishida Yuichi , Liew J. Y. Richard , Iyama Jun 
Published: March 2020

AbstractThis paper is a study on the behaviour of a composite joint between a steel beam and a concrete encased steel composite column, where the steel beam is connected to a steel column by a fin‐plate connection and the steel column and joint are subsequently encased by reinforced concrete to form a composite column. This joint is named “embedded joint”. Although this type of joints is designed as a simple pin joint in practice, it can transfer a fair amount of shear force and bending moment primarily through bearing stress between the steel beam and the surrounding concrete. To propose a rational joint behavioural model in line with the current Eurocodes, the bearing component of base plate connections shown in EN1993‐1‐8 is firstly applied. The proposed model is then compared with full‐scale joint loading tests to verify its accuracy in predicting the rotational stiffness and the moment resistance.
FIRE RESISTANCE OF STAINLESS STEEL AXIALLY LOADED ELLIPTICAL HOLLOW SECTION COLUMNS
Authors: Arrais Flávio , Lopes Nuno , Real Paulo Vila 
Published: March 2020

AbstractIn spite of the initial cost of stainless steel, its application as a structural material has been increasing. Stainless steel has different advantages when compared to conventional carbon steel. The corrosion resistance and aesthetic appearance are the most known, but its higher fire resistance can also be decisive. This work presents a numerical study on the behaviour of stainless steel members composed of elliptical hollow sections subjected to axial compression at elevated temperatures. The numerical ultimate load bearing capacities were obtained applying finite element models and the results were compared with simplified calculation formulae from Eurocode 3, concluding that this methodology is not appropriate for the type of profiles here analysed.
WELDED T‐JOINTS BETWEEN RECTANGULAR HOLLOW SECTION MEMBERS WITH OFFSET
Authors: Kalmykova Svitlana , Wald František 
Published: March 2020

AbstractThe current study is devoted to mechanical resistance of so‐called offset welded RHS joints where RHS brace members are offset from the chord centreline under brace axial compression. Paper presents numerical investigation results of structural behaviour of mentioned joints under monotonically increased load. For these purposes, Abaqus FE‐models were developed by using C3D8R 8‐noded solid linear brick elements with attention to mesh size effect and weld modelling. The force‐displacement curves corresponding to different geometries of joints were analysed focusing on the failure modes. Based on conducted numerical simulations, deformation limits and failure criteria for offset joints were adopted and verified. It is stated that the 3%b0 ultimate deformation limit chosen by Lu et al. (1994) and adopted by the IIW as main criterion of joints' failure could be reasonable revised.
COMPOSITE BEHAVIOUR OF COLD‐FORMED STEEL ‐ TIMBER FLOORS
Authors: Raffoul Samar , Moutaftsis Dimitrios , Heywood Martin , Rowell Michael 
Published: March 2020

AbstractThis article investigates, experimentally, the structural performance of lightweight cold‐formed steel (CFS) ‐ timber board composite flooring systems. Fifteen full‐scale bending tests and twelve companion pushout connection tests were performed. The effect of connection detail (comprising self‐drilling screws with or without a structural adhesive) on structural performance is examined. The results of this research demonstrate that the use of a polyurethane adhesive, in conjunction with screws, leads to a significant increase in connection slip modulus and a higher degree of composite action in the floors, resulting in up to 40% increase in flexural stiffness, when compared to joists designed individually. The experimental results are then compared to predictions from relevant existing analytical models.
STABILITY OF STRUTS AND FRAMES: BACKGROUND AND DESIGN METHODS ACCORDING TO EUROCODE 3
Authors: Pimentel Ricardo J. A. G. , Simões Rui A. D. 
Published: March 2020

AbstractStructural stability is one of the key aspects in the structural engineering practice. Following current architectural trends, steel and composite structures tend to be slender and flexible, which may lead to a necessity to consider the deformed structural shape to the analysis and design. This paper provides a background overview about structural stability and second order effects according to the Eurocode 3. The proposed methods for addressing these effects according to The Eurocode 3 will be presented. Computational methods to assess structural stability will be discussed. Practical design examples for each Eurocode method are presented.
NUMERICAL ANALYSIS WITH IMPLEMENTATION OF DAMAGE TO STAINLESS STEEL BOLTED CONNECTIONS SUBJECTED TO SHEAR LOAD
Authors: Sobrinho Kelvin P. , Silva André T. , Rodrigues Monique C. , Henriques José A. G. , Vellasco Pedro C. G. S. , Lima Luciano R. O. 
Published: March 2020

AbstractIn this paper, an experimental and numerical study were developed to evaluate the behavior of stainless steel bolted connections subjected to shear load until rupture, in which austenitic stainless steel 304 was used. In order to determine the material behavior, tensile coupon tests were performed. The numerical model was developed in Abaqus finite element program using dynamic explicit analysis and solid elements (C3D8) with an elastic‐plastic stress‐strain curve with strain hardening and damage criteria. Additionally, a comparison of the results with the recommendations given by the current standards for stainless steel structures was also accomplished.
Interception of Elusive Cationic Hf–Al and Hf–Zn Heterobimetallic Adducts with Mixed Alkyl Bridges Featuring Multiple Agostic Interactions
Authors: Tensi Leonardo , Froese Robert D. J. , Kuhlman Roger L. , Macchioni Alceo , Zuccaccia Cristiano 
Published: March 2020

AbstractInvited for the cover of this issue is the group of Cristiano Zuccaccia at the Università degli Studi di Perugia. The image depicts a relation of the nuances of chemical bonding to the diverse ways that animals “bind” to their natural surroundings. Read the full text of the article at 10.1002/chem.201905699.
Pressure dependence of vibrational optical activity of model biomolecules. A computational study
Authors: Plamitzer Luboš , Bouř Petr 
Published: March 2020

AbstractChange of molecular properties with pressure is an attracting means to regulate molecular reactivity or biological activity. However, the effect is usually small and so far explored rather scarcely. To obtain a deeper insight and estimate the sensitivity of vibrational optical activity spectra to pressure‐induced conformational changes, we investigate small model molecules. The Ala‐Ala dipeptide, isomaltose disaccharide and adenine‐uracil dinucleotide were chosen to represent three different biomolecular classes.The pressure effects were modeled by molecular dynamics and density functional theory simulations. The dinucleotide was found to be the most sensitive to the pressure, whereas for the disaccharide the smallest changes are predicted. Pressure‐induced relative intensity changes in vibrational circular dichroism and Raman optical activity spectra are predicted to be 2–3‐times larger than for non‐polarized IR and Raman techniques.
Kinetic Modeling of Rhodium‐Catalyzed Reductive Amination of Undecanal in Different Solvent Systems
Authors: Kirschtowski Sabine , Kadar Christof , Seidel‐Morgenstern Andreas , Hamel Christof 
Published: March 2020

AbstractThe homogenously rhodium‐catalyzed reductive amination of 1‐undecanal was performed in two different thermomorphic solvent systems with the ligand Xantphos. The influences of partial pressure, temperature, methanol and catalyst concentration on the reaction were investigated. Based on a network analysis a kinetic model was derived and successfully parametrized for all studied solvent systems. Simulation results were found to be in good agreement with the experiments and allow a further process development and optimization.
Diversity and heterotic patterns in North American proprietary dent maize germplasm
Authors: White Michael R. , Mikel Mark A. , de Leon Natalia , Kaeppler Shawn M. 
Published: March 2020

AbstractPublicly available maize (Zea mays L.) inbred lines with expired Plant Variety Protection certificates (ex‐PVP) constitute the elite germplasm used in hybrids grown by North American farmers during the past half century. A set of 329 ex‐PVP inbreds and eight public reference inbreds was evaluated for genetic diversity using molecular marker and pedigree‐based relationships. The majority of inbreds originated from Dekalb Genetics Corporation, Holden's Foundation Seed, Pioneer Hi‐Bred International, and Syngenta via Novartis and Northrup King. Flowering ranged from 968–1806 growing degree days to anthesis, supporting that these inbreds represent adaptation across the range of North American production environments. Admixture analysis supported eight subgroups (B14, B37, B73, Oh43, Iodent, Iodent‐Lancaster, Lancaster, and Flint), reflecting heterotic patterns and company of origin. Five diallel‐cross experiments identified primary yield heterotic patterns within early‐, intermediate‐, and late‐maturity groups. Parental pedigree information was compiled for 2392 Plant Variety Protection and/or utility patented inbreds through 2017, allowing for multigenerational analysis of progenitors and the eight heterotic subgroups across current proprietary breeding programs. Key progenitors were identified for recently merged companies, Bayer Crop Science and Corteva Agriscience. The results of this study strengthen the value of the ex‐PVP inbreds as a source of elite and relevant germplasm for breeders and researchers to exploit. This study provides information that will be logistically useful to researchers who use ex‐PVP inbreds and adds to our understanding of heterotic grouping within North American proprietary germplasm.
Impact of cultivar and environment soil suitability on the contribution of yield components to grain yield variation in spring wheat
Authors: Sobczyński Grzegorz , Studnicki Marcin , Mądry Wiesław , Wijata Magdalena , Gozdowski Dariusz , Noras Kinga , Samborski Stanisław , Rozbicki Jan 
Published: March 2020

AbstractThe objectives of this study were to determine how modern cultivars of spring wheat (Triticum aestivum L. var. vulgare) and different soil conditions at locations in Poland affected grain yield (GY) of 15 cultivars and multiplicative yield components. The different ways in which the components contributed to GY variation created by environmental conditions—location, growing season, and crop management—across environments of favorable and unfavorable soil suitability for wheat cultivation were also determined. To assess the relationship between GY and its components for cultivars grown under two levels of soil suitability, path coefficient analysis was used. Cluster analysis of three GY components—the number of spikes per square meter (SN), the number of grains per spike (NG/S), and the thousand‐grain weight (TGW)—derived from different cultivar × soil suitability combinations was performed to identify groups of these combinations and to assess the ways in which yield components vary in their contribution to GY in the varied environments. Grain yield and its three components were significantly affected by main and interaction effects of the cultivar and the level of soil suitability. Grain yield in favorable and unfavorable soil suitability conditions was, respectively, 6.58–5.44 Mg ha−1. This decrease was due to a reduction in SN by 6.1% and in TGW by 11.8%, but NG/S was similar in both soil groups. Grain yield variability in response to the different environmental conditions was determined by similar contributions of the three yield components, almost independently of the cultivar, but in the favorable suitability, SN had a stronger impact on GY, whereas in unfavorable soil suitability for wheat cultivation, the importance of NG/S increased.