bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Pilot Study of Anxiety Sensitivity and Adolescent Sports-Related Concussion
Authors: Caze Todd , Vásquez Desi , Moffatt Kody , Waple Kerry , Hope Debra 
Published: December 2020

AbstractObjectiveThis study examined the relationship of that anxiety sensitivity (AS) with the initial and ongoing symptoms reported by adolescents after sustaining a sports-related concussion (SRC).MethodParticipants were 40 adolescents, ages 13–18, presenting for treatment at a children’s sports medicine specialty clinic following a diagnosis of either an SRC or a musculoskeletal injury. After the initial clinic intake, participants completed an online survey at three-time points. Survey measures included the self-report graded symptom checklist and the AS Index-3. Researchers used growth curve analysis to examine the relationship between AS Index-3 scores with initial and ongoing symptom reporting over time. The 20 participants sustaining an SRC were matched by age, gender, and race with 20 musculoskeletal injury controls.ResultsConcussed adolescents with higher AS scores reported more initial symptoms than did those reporting musculoskeletal injury. AS was not related to the rate of symptom reduction over time for either group.ConclusionHigher AS moderated the relationship between injury type (concussion vs. musculoskeletal injury) and the total number of initial symptoms reported by adolescent participants, with every unit increase in AS yielding a four-unit increase in initial symptoms reporting. Previous research has shown that elevated initial symptom scores are a strong predictor of protracted recovery in concussion. AS is amenable to brief treatment interventions. It is a potential early target for treatment intervention following diagnosis of adolescent SRC.
Gene expression profiling of SARS-CoV-2 infections reveal distinct primary lung cell and systemic immune infection responses that identify pathways relevant in COVID-19 disease
Authors: Moni Mohammad Ali , Quinn Julian M W , Sinmaz Nese , Summers Matthew A 
Published: December 2020

Abstract
To identify key gene expression pathways altered with infection of the novel coronavirus SARS-CoV-2, we performed the largest comparative genomic and transcriptomic analysis to date. We compared the novel pandemic coronavirus SARS-CoV-2 with SARS-CoV and MERS-CoV, as well as influenza A strains H1N1, H3N2 and H5N1. Phylogenetic analysis confirms that SARS-CoV-2 is closely related to SARS-CoV at the level of the viral genome. RNAseq analyses demonstrate that human lung epithelial cell responses to SARS-CoV-2 infection are distinct. Extensive Gene Expression Omnibus literature screening and drug predictive analyses show that SARS-CoV-2 infection response pathways are closely related to those of SARS-CoV and respiratory syncytial virus infections. We validated SARS-CoV-2 infection response genes as disease-associated using Kaplan–Meier survival estimates in lung disease patient data. We also analysed COVID-19 patient peripheral blood samples, which identified signalling pathway concordance between the primary lung cell and blood cell infection responses.
Identification of sub-Golgi protein localization by use of deep representation learning features
Authors: Lv Zhibin , Wang Pingping , Zou Quan , Jiang Qinghua 
Published: December 2020

Abstract

Motivation
The Golgi apparatus has a key functional role in protein biosynthesis within the eukaryotic cell with malfunction resulting in various neurodegenerative diseases. For a better understanding of the Golgi apparatus, it is essential to identification of sub-Golgi protein localization. Although some machine learning methods have been used to identify sub-Golgi localization proteins by sequence representation fusion, more accurate sub-Golgi protein identification is still challenging by existing methodology.

Results
we developed a protein sub-Golgi localization identification protocol using deep representation learning features with 107 dimensions. By this protocol, we demonstrated that instead of multi-type protein sequence feature representation fusion as in previous state-of-the-art sub-Golgi-protein localization classifiers, it is sufficient to exploit only one type of feature representation for more accurately identification of sub-Golgi proteins. Compared with independent testing results for benchmark datasets, our protocol is able to perform generally, reliably and robustly for sub-Golgi protein localization prediction.

Availabilityand implementation
A use-friendly webserver is freely accessible at http://isGP-DRLF.aibiochem.net and the prediction code is accessible at https://github.com/zhibinlv/isGP-DRLF.

Supplementary information
Supplementary data are available at Bioinformatics online.
The Political Economy of Peer Research: Mapping the Possibilities and Precarities of Paying People for Lived Experience
Authors: MacKinnon Kinnon R , Guta Adrian , Voronka Jijian , Pilling Merrick , Williams Charmaine C , Strike Carol , Ross Lori E 
Published: December 2020

Abstract
Participatory research, or the practice of involving ‘peers’ with lived experience, has become popular in social work. Peer engagement is lauded for: ‘democratising’ the research process; providing ‘capacity building’ and facilitating opportunities to co-produce knowledge. Yet, these claims are rarely evaluated by empirical investigations into the socio-material work conditions of peer researchers. Here we present findings of a study that examined the experiences of peer researchers, focusing on payment inequities and social workers’ roles in advocating for economic justice. Together with peer research assistants, we conducted a participatory constructivist grounded theory study, interviewing peers (total n = 34) who were compensated to work on studies focused on the following: racialised communities, communities of people who use drugs, consumer/psychiatric survivor/ex-patient and mad communities and trans/non-binary communities. Our findings highlight divergent compensation practices in peer research work. Whilst some peers were satisfied with their treatment on research teams and payment received, others discussed challenges associated with precarious short-term casual work and managing formal income alongside state social assistance such as disability support. We conclude that in some cases, the peer role is characterised by precarious working conditions which compound rather than challenge injustice within the research enterprise, and we discuss implications for social work.
Discrimination of Complex Odor Mixtures: A Study Using Wine Aroma Models
Authors: Luckett Curtis R , Pellegrino Robert , Heatherly Michelle , Alfaro Martinez Katherine , Dein Melissa , Munafo P John 
Published: December 2020

Abstract
There are key unanswered questions when it comes to multicomponent odor discrimination. This study was designed to assess discrimination of odorant mixtures that elicit a singular percept. We collected data to address the following two questions: (1) What odor features do humans notice when attempting to discriminate between subtly different odor mixtures? (2) Are odor mixtures easier to discriminate when an odorant is added, compared with when a component is removed? Using modern aroma chemistry techniques, an odor mixture resembling a generic white wine was constructed. This wine odor mixture was modified using a series of three esters which are commonly found in white wines that vary in chain length and branching. Participants performed a sequence of discrimination tasks for the addition/subtraction of modifiers to the base wine at different concentrations. Only one of the esters (ethyl propanoate) led to a discriminable odor mixture. As concentration of the modifying odorant was increased, discrimination of odor mixtures was first reported because of changes in odor mixture familiarity and then intensity. We found similar sensitivity to changes in odor mixtures regardless whether the modifying compound was added or subtracted, suggesting that perceptual stability of odor mixtures is equally dependent on both imputing missing information (pattern completion) and disregarding extraneous information.
The Question of Jurisdiction in the 2019 Arbitration between Ukraine and Russia
Authors: Jia Bing Bing 
Published: December 2020

Abstract
This case, involving the Kerch Strait and the Sea of Azov, was initiated by Ukraine against Russia under Annex VII, UNCLOS, on 1 April 2019. Having cleared the stage of provisional measures before the ITLOS, it is pending before an arbitral tribunal established under Annex VII. After the ITLOS proceedings, there is room either to broaden the scope of jurisdiction for the tribunal or to narrow it. The question of jurisdiction to be considered here reflects wider issues common to other arbitral proceedings under Annex VII. Two propositions will therefore be considered. The first is that, as the dispute may lie in the source of the supposed right for the Ukrainian warships to pass through the strait, the 2003 Cooperation Agreement may displace the UNCLOS, divesting the tribunal of jurisdiction. The second proposition is that, if the incident of 25 November 2018 involves, solely or primarily, a dispute concerning the interpretation or application of the UNCLOS, the provisions should include those of Articles 19, 25 (1), 30, 45, and 311, which provide other causes of action.
Stress and reproductive events detected in North Atlantic right whale blubber using a simplified hormone extraction protocol
Authors: Graham Katherine M , Burgess Elizabeth A , Rolland Rosalind M 
Published: December 2020

AbstractAs studies quantifying steroid hormones in marine mammal blubber progress, methodological refinements may improve the utility and consistency of blubber hormone measurements. This study advances blubber extraction methodologies by testing a simplified extraction protocol that reduces time and complexity compared to a protocol widely used in cetacean blubber studies. Using blubber samples archived from remote biopsy (n = 21 live whales) and necropsy collection (n = 7 dead whales) of North Atlantic right whales (NARW; Eubalaena glacialis) of known life history states, we performed analytical and biological validations to assess the feasibility of measuring reproductive (testosterone, progesterone) and glucocorticoid (cortisol) hormones in blubber via enzyme immunoassay following the simplified extraction. Analytical validations (parallelism, accuracy, extraction efficiency, repeatability) showed the simplified extraction produced similar results to the extended protocol, offering a more efficient and consistent technique. In live, apparently healthy whales, blubber testosterone concentrations (mean ± SE) were significantly higher in males (2.02 ± 0.36 ng/g) compared to females (0.81 ± 0.15 ng/g). Blubber progesterone was highest in a confirmed pregnant female (60.3 ng/g), which was 12-fold greater than the mean concentration of non-pregnant females (4.56 ± 0.88 ng/g). Blubber cortisol concentrations in whales that died from anthropogenic causes averaged 5.31 ± 2.28 ng/g, whereas most live, healthy whales had cortisol values below 1 ng/g. Among living whales, a whale actively entangled in fishing gear had the highest blubber cortisol measurement (3.51 ng/g), exhibiting levels similar to whales that died from acute entanglement (2.88 ± 0.42 ng/g). Overall, the highest blubber cortisol concentration (18.0 ng/g) was measured in a dead whale with a severe chronic entanglement, approximately 30-fold greater than mean blubber cortisol of apparently healthy whales (0.58 ± 0.11 ng/g). The methodological approach presented here provides a reference for researchers interested in an alternative, streamlined technique for hormone extraction of cetacean blubber and contributes to the diverse tool set for stress and reproductive assessments of endangered NARWs.
Outcomes of primary sternal closure for postoperative mediastinitis in children
Authors: Tsuji Shigeto , Ikai Akio , Oyama Kotaro , Kin Hajime , Koizumi Junichi 
Published: December 2020

Abstract OBJECTIVESWe retrospectively analysed outcomes of debridement and primary sternal closure for postoperative mediastinitis in children.METHODSBetween January 2007 and July 2019, 1285 patients under the age of 20 years underwent congenital heart surgery at the Iwate Medical University. Of these, 22 children had postoperative mediastinitis (1.7%). We performed adequate debridement and primary sternal closure with pectoralis major muscle advancement flaps. We evaluated hospital survival rates, reintervention, duration of intravenous antibiotic treatment, intensive care unit (ICU) stay and hospital stay.RESULTSThe median age and weight at surgery were 12.5 months (range 0–228 months) and 7.8 kg (range 2.2–64.2 kg), respectively. Two patients (9%) had a history of delayed sternal closure. Staphylococcus was the most common causative agent for infection (82%). All cases were categorized as Robicsek’s classification type II mediastinitis. The hospital survival rate was 95%, and freedom from reintervention for infectious complications was observed in 91% of the patients. The median durations of intravenous antibiotic treatment, ICU stay and hospital stay were 18 days (range 9–46 days), 4 days (range 1–87 days) and 22.5 days (range 11–87 days). The median follow-up time was 89 months (range 2–148 months), and there was no evidence of recurrent mediastinitis, musculoskeletal growth, physical deformity, breast development and upper trunk or limb movement.CONCLUSIONSPrimary sternal closure is an effective procedure for children as it can significantly shorten treatment duration and reduce physical and psychological burdens. Its results compare favourably with those of conventional therapy in terms of mortality and complications.
Continuing to Participate in the Dance of Life as Oneself: The Lived Experience of Meaning in Life for Older Adults With Alzheimer’s Disease
Authors: Dewitte Laura , van Wijngaarden Els , Schellekens Tine , Vandenbulcke Mathieu , Dezutter Jessie 
Published: December 2020

Abstract

Background and Objectives
Meaning in life is an important aspect of positive psychological functioning for older adults. Limited work suggests the relevance of the experience of meaning for people with dementia, but research into this experience from their personal perspective is lacking. The current study provides an in-depth investigation of the lived experience of meaning in life for older adults with Alzheimer’s disease.

Research Design and Methods
The study was conducted following the phenomenological reflective lifeworld approach. In-depth interviews were conducted with 16 older adults (+65) with Alzheimer’s disease living either at home or in a nursing home in Belgium. Data analysis was an iterative process aimed at illuminating the constituents and essence of the phenomenon.

Results
The essence of the experience of meaning in life for participants was understood as “continuing to participate in the dance of life as oneself.” This experience was further clarified in four closely intertwined constituents: (a) feeling connected and involved, (b) continuing everyday life as oneself, (c) calmly surrendering and letting go, and (d) desiring freedom, growth, and invigoration.

Discussion and Implications
Our findings contribute to a deeper understanding of meaning in life as experienced by older adults with Alzheimer’s disease themselves. They emphasize the relevance of the concept for psychological dementia research and offer original insight for the inclusion of meaning in life as an important aspect of holistic dementia care.
Poor coverage and quality for poor women: Inequalities in quality antenatal care in nine East African countries
Authors: Bobo Firew Tekle , Asante Augustine , Woldie Mirkuzie , Hayen Andrew 
Published: December 2020

Abstract
The use of quality antenatal care (ANC) improves maternal and newborn health outcomes. Ensuring equity in access to quality maternal health services is a priority agenda in low- and middle-income countries. This study aimed to assess inequalities in the use of quality ANC in nine East African countries using the most recent Demographic and Health Surveys. We used two outcome variables to examine ANC service adequacy: four or more ANC contacts and quality ANC. We defined quality ANC as having six of the recommended ANC components during follow-up: blood pressure measurement, urine sample test, blood sample test, provision of iron supplements, drug for intestinal parasite and tetanus toxoid injections. We used the concentration index (CCI) to examine inequalities within and across countries. We fitted a multilevel regression model to assess the predictors of inequalities in the contact and content of ANC. This study included 87 068 women; among those 54.4% (n = 47 387) had four or more ANC contacts, but only 21% (n = 15 759) reported receiving all six services. The coverage of four or more ANC and receipt of all six services was pro-rich within and across all countries. The highest inequality in four or more ANC contacts was in Ethiopia with a CCI of 0.209, while women in Burundi had the highest inequality in coverage of all six services (CCI: 0.318). Higher education levels and media exposure were predictors of service uptake, while women who had unintended pregnancies were less likely to make four or more ANC contacts and receive six services. Interventions to improve access to quality ANC require rethinking the service delivery mechanisms in all countries. Moreover, ensuring equity in access to quality ANC requires tailoring service delivery modalities to address the social determinants of service uptake.
Fundamental Rights Implications of Interconnecting Migration and Policing Databases in the EU
Authors: Blasi Casagran Cristina 
Published: December 2020

Abstract
On 11 June 2019, two Interoperability European Union (EU) Regulations entered into force. With it, six existing EU databases created for security and border management purposes merged into one single, overarching EU information system operating with the purpose of changing the way front-line officers worked in various tasks. The main objective of these Regulations was to prevent and combat illegal immigration and to improve security within the Area of Freedom, Security and Justice of the Union. This article studies the challenges that have emerged from making EU databases and information systems ‘interoperable’ as well as the potential negative consequences that the Regulations may have for fundamental rights as enshrined in the EU Charter of Fundamental Rights. In particular, it examines whether the interoperability between EU information systems could violate the rights related to data protection, rights of the child, prohibition of discrimination as well as principles of necessity and proportionality.
Regulatory Responses to ‘Fake News’ and Freedom of Expression: Normative and Empirical Evaluation
Authors: Helm Rebecca K , Nasu Hitoshi 
Published: December 2020

Abstract
National authorities have responded with different regulatory solutions in attempts to minimise the adverse impact of fake news and associated information disorder. This article reviews three different regulatory approaches that have emerged in recent years—information correction, content removal or blocking, and criminal sanctions—and critically evaluates their normative compliance with the applicable rules of international human rights law and their likely effectiveness based on an evidence-based psychological analysis. It identifies, albeit counter intuitively, criminal sanction as an effective regulatory response that can be justified when it is carefully tailored in a way that addresses legitimate interests to be protected.
Persistence of SARS-CoV-2 in the first trimester placenta leading to transplacental transmission and fetal demise from an asymptomatic mother
Authors: Shende Prajakta , Gaikwad Pradip , Gandhewar Manisha , Ukey Pawankumar , Bhide Anshul , Patel Vainav , Bhagat Sharad , Bhor Vikrant , Mahale Smita , Gajbhiye Rahul , Modi Deepak 
Published: December 2020

Abstract
Coronavirus disease 2019 (COVID-19) is caused by infection of the respiratory tract by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which survives in the tissues during the clinical course of infection but there is limited evidence on placental infection and vertical transmission of SARS-CoV-2. The impact of COVID-19 in first trimester pregnancy remains poorly understood. Moreover, how long SARS-CoV-2 can survive in placenta is unknown. Herein, we report a case of a pregnant woman in the first trimester who tested positive for SARS-CoV-2 at 8 weeks of gestation, although her clinical course was asymptomatic. At 13 weeks of gestation, her throat swab tested negative for SARS-CoV-2 but viral RNA was detected in the placenta, and the Spike (S) proteins (S1 and S2) were immunolocalized in cytotrophoblast and syncytiotrophoblast cells of the placental villi. Histologically, the villi were generally avascular with peri-villus fibrin deposition and in some areas the syncytiotrophoblast layer appeared lysed. The decidua also had fibrin deposition with extensive leukocyte infiltration suggestive of inflammation. The SARS-CoV-2 crossed the placental barrier, as the viral RNA was detected in the amniotic fluid and the S proteins were detected in the fetal membrane. Ultrasonography revealed extensively subcutaneous edema with pleural effusion suggestive of hydrops fetalis and the absence of cardiac activity indicated fetal demise. This is the first study to provide concrete evidence of persistent placental infection of SARS-CoV-2 and its congenital transmission is associated with hydrops fetalis and intrauterine fetal demise in early pregnancy.
Emergency surgical stent retrieval following stent dislodgement during ductal stenting for hybrid palliation
Authors: Tongut Aybala , Desai Manan , Peer Syed Murfad , Yerebakan Can 
Published: December 2020

Abstract
Stenting of the ductus arteriosus is part of the hybrid treatment of high-risk patients with hypoplastic left heart syndrome. Dislodgement of a ductal stent is a rare complication. We present challenges faced in successful surgical retrieval of a dislodged ductal stent in a high-risk infant undergoing hybrid palliation for hypoplastic left heart syndrome.