bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of hypoxemia among pediatric and adult patients presenting to healthcare facilities in low- and middle-income countries: protocol for a systematic review and meta-analysis
Authors: Lam Felix , Subhi Rami , Houdek Jason , Schroder Kate , Battu Audrey , Graham Hamish 
Published: March 2020

Abstract
Background
Hypoxemia is a severe condition associated with high rates of mortality, particularly in low- and middle-income countries (LMICs) with poor access to oxygen therapy. Despite its clinical significance, there have been few studies to describe the burden of hypoxemia. Thus, the primary objective of this study is to systematically describe the prevalence of hypoxemia among pediatric and adult patients in low- and middle-income countries.

Methods/design
Standard systematic review methods will be used. Bibliographic databases (MEDLINE, EMBASE, CINAHL) will be searched from 1998 onwards. The search strategy aims to identify studies that have measured peripheral blood oxygen saturation (SpO2) in children and adults presenting to health facilities in LMICs. Studies will be included if oxygen saturation measurements by pulse oximetry were measured. No studies will be excluded based on study design though patients recruited from intensive care units and post-operative care will be excluded. The primary outcome is the prevalence of hypoxemia on presentation to the healthcare facility. We define hypoxemia on the basis of SpO2 measurements, and use a threshold of SpO2 less than 90% at sea level though allow for a lower threshold for studies conducted at higher altitude and where justified. Standardized tools will be used to extract data on number of patients with SpO2 measurements, number of patients with hypoxemia, patient population characteristics, and study characteristics. Quality of the included studies will be assessed using the “Checklist for Prevalence Studies” developed by the Joanna Briggs Institute. If there are enough studies to do so, we will conduct meta-analysis using a random effects model to estimate prevalence of hypoxemia and conduct subgroup analyses by age and disease groups.

Discussion
Hypoxemia is a critical condition and understanding the burden of hypoxemia may support decision-making in LMICs to deploy pulse oximeters and oxygen treatments more efficiently to address diseases and patient populations with the highest burden. Previous studies on hypoxemia prevalence have focused too narrowly on a few diseases or specific patient populations (e.g., pneumonia in children under five) whereas any effort to improve access to oxygen requires understanding of the potential demand for oxygen for all diseases and population groups. Governments, UN agencies, donors, and NGOs are investing strongly to improve oxygen systems in LMICs. Effective oxygen system planning requires estimation of oxygen need, informed by robust data on hypoxemia prevalence and admission patterns at all the levels of the health system. This study aims to fill that gap by providing comprehensive estimates of hypoxemia prevalence.

Systematic review registration
PROSPERO CRD42019136622.
Criteria for a certain class of the Carathéodory functions and their applications
Authors: Cho Nak Eun , Srivastava H. M. , Analouei Adegani Ebrahim , Motamednezhad Ahmad 
Published: March 2020

AbstractIn this paper, we obtain some potentially useful conditions (or criteria) for the Carathéodory functions as a certain class of analytic functions by applying Nunokawa’s lemma. We also obtain several conditions for strong starlikeness and close-to-convexity as special cases of the main results presented here.
Exponential type convexity and some related inequalities
Authors: Kadakal Mahir , İşcan İmdat 
Published: March 2020

AbstractIn this manuscript, we give and study the concept of exponential type convex functions and some of their algebraic properties. We prove two Hermite–Hadamard (H-H) type integral inequalities for the newly introduced class of functions. We also obtain some refinements of the H-H inequality for functions whose first derivative in absolute value at certain power is exponential type convex.
Study of implicit delay fractional differential equations under anti-periodic boundary conditions
Authors: Ali Arshad , Shah Kamal , Abdeljawad Thabet 
Published: March 2020

AbstractThis research work is related to studying a class of special type delay implicit fractional order differential equations under anti-periodic boundary conditions. With the help of classical fixed point theory due to Schauder and Banach, we derive some results about the existence of at least one solution. Further, we also study some results including Hyers–Ulam, generalized Hyers–Ulam, Hyers–Ulam Rassias, and generalized Hyers–Ulam–Rassias stability. We provide some test problems for illustrating our analysis.
3D inversion of the Sichuan Basin magnetic anomaly in South China and its geological significance
Authors: Wang Jie , Yao Changli , Li Zelin , Zheng Yuanman , Shen Xuhui , Zeren Zhima , Liu Wenlong 
Published: March 2020

AbstractThe Sichuan Basin magnetic anomaly is the most striking regional aeromagnetic anomaly in South China. It is characterized by a continuous large-scale linear magnetic anomaly and contains long-wavelength constituents which could still be detected on satellites. However, Sichuan Basin is covered by 4 to 10 km thick non-magnetic sedimentary layers from Neoproterozoic to Cenozoic, which conceals the magnetic sources in the Precambrian basement and makes it difficult to explore the geological origin of the Sichuan Basin magnetic anomaly. In this study, we applied 3D inversion to the magnetic data, and then compared our inverted susceptibility model with geological maps. We found that the spatial distribution of the Sichuan Basin magnetic anomaly controls the range of the rigid basement beneath Sichuan Basin and it is surrounded by the widespread Neoproterozoic magmatic complexes. Based on our analysis, we proposed that the geological origin of the Sichuan Basin magnetic anomaly might be related to the craton-scale Neoproterozoic magmatic event, which has played an important role in the stabilization of the basement and the evolution of the deep crust in Sichuan Basin.
Stiff and safe task-space position and attitude controller for robotic manipulators
Authors: Byun Gyuho , Kikuuwe Ryo 
Published: March 2020

AbstractThis paper proposes a stiff and safe task-space position and attitude control scheme for robotic manipulators. This study extends the work of Kikuuwe et al’s. (2006) velocity-bounding proxy-based sliding mode control by explicitly addressing the attitude part. The proposed controller has a Jacobian-based structure, which realizes smooth trajectories when the desired attitude is far rotated from the actual attitude. It also imposes arbitrary magnitude limits on the end-effector velocity, angular velocity, and each actuator force without sacrificing a stiffness, which is the same level as a high-gain PID position control below the limits. The benefit of the proposed controller becomes apparent after the robot yields to external forces due to force saturations, when the robot makes contact with obstacles. In such a situation, if the external forces disappear, the controller generates overdamped resuming motion from large tracking errors. The proposed controller can be expected to enhance the safety of robotic applications for the human–robot interaction. The proposed method is validated by experiments employing a six-degree of freedom industrial manipulator.
Comparison of two elastic motion correction approaches for whole-body PET/CT: motion deblurring vs gate-to-gate motion correction
Authors: Pösse Stefanie , Büther Florian , Mannweiler Dirk , Hong Inki , Jones Judson , Schäfers Michael , Schäfers Klaus Peter 
Published: March 2020

Abstract
Background
Respiratory motion in PET/CT leads to well-known image degrading effects commonly compensated using elastic motion correction approaches. Gate-to-gate motion correction techniques are promising tools for improving clinical PET data but suffer from relatively long reconstruction times. In this study, the performance of a fast elastic motion compensation approach based on motion deblurring (DEB-MC) was evaluated on patient and phantom data and compared to an EM-based fully 3D gate-to-gate motion correction method (G2G-MC) which was considered the gold standard.

Methods
Twenty-eight patients were included in this study with suspected or confirmed malignancies in the thorax or abdomen. All patients underwent whole-body [18F]FDG PET/CT examinations applying hardware-based respiratory gating. In addition, a dynamic anthropomorphic thorax phantom was studied with PET/CT simulating tumour motion under controlled but realistic conditions. PET signal recovery values were calculated from phantom scans by comparing lesion activities after motion correction to static ground truth data. Differences in standardized uptake values (SUV) and metabolic volume (MV) between both reconstruction methods as well as between motion-corrected (MC) and non motion-corrected (NOMC) results were statistically analyzed using a Wilcoxon signed-rank test.

Results
Phantom data analysis showed high lesion recovery values of 91% (2 cm motion) and 98% (1 cm) for G2G-MC and 83% (2 cm) and 90% (1 cm) for DEB-MC. The statistical analysis of patient data found significant differences between NOMC and MC reconstructions for SUV max, SUV mean, MV, and contrast-to-noise ratio (CNR) for both reconstruction algorithms. Furthermore, both methods showed similar increases of 11–12% in SUV max and SUV mean after MC. The statistical analysis of the MC/NOMC ratio found no significant differences between the methods.

Conclusion
Both motion correction techniques deliver comparable improvements of SUV max, SUV mean, and CNR after MC on clinical and phantom data. The fast elastic motion compensation technique DEB-MC may thereby be a valuable alternative to state-of-the art motion correction techniques.
GAN-based synthetic brain PET image generation
Authors: Islam Jyoti , Zhang Yanqing 
Published: March 2020

AbstractIn recent days, deep learning technologies have achieved tremendous success in computer vision-related tasks with the help of large-scale annotated dataset. Obtaining such dataset for medical image analysis is very challenging. Working with the limited dataset and small amount of annotated samples makes it difficult to develop a robust automated disease diagnosis model. We propose a novel approach to generate synthetic medical images using generative adversarial networks (GANs). Our proposed model can create brain PET images for three different stages of Alzheimer’s disease—normal control (NC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD).
Male breast metastasis of ureteral cancer: a case report
Authors: Ishikawa Yoshitaka , Tabei Isao , Fushimi Atsushi , Fuke Azusa , Sekine Chikako , Okamoto Tomoyoshi , Takeyama Hiroshi 
Published: March 2020

Abstract
Background
Breast metastasis from extra-mammary primary tumors is extremely rare. We recently experienced a rare case of a male breast metastasis of ureteral cancer and will provide a case report.

Case presentation
A 74-year-old man developed a ureteral cancer and underwent left nephroureterectomy with lymph node dissection. Although enlarged abdominal lymph nodes did not disappear completely after chemoradiotherapy, further extensive therapy was not performed. A mass just below the nipple of his right breast was acknowledged and he visited our department. Histological diagnosis was invasive carcinoma. It was initially diagnosed as a primary breast cancer, and he underwent a mastectomy and a sentinel lymph node biopsy. There was no intraductal lesion and the border of the tumor was clear. It was very similar to that of the previous ureteral cancer. The final diagnosis was breast metastasis of ureteral cancer rather than primary breast cancer. The postoperative course was good, but multiple lung metastases appeared 2 months after surgery. He eventually died of cancerous lymphangiopathy.

Conclusion
It is important to accurately diagnose primary breast cancer or breast metastasis so as not to cause extra-invasion, but it was considered difficult to make a complete preoperative diagnosis.
Thoracoscopic esophagectomy with left recurrent laryngeal nerve monitoring for thoracic esophageal cancer in a patient with a right aortic arch: a case report
Authors: Ninomiya Yamato , Oguma Junya , Ozawa Soji , Koyanagi Kazuo , Kazuno Akihito , Yamamoto Miho , Yatabe Kentaro 
Published: March 2020

Abstract
Background
Surgery for cases of thoracic esophageal cancer with a right aortic arch is rare, and the anatomic abnormalities in such patients necessitate a different surgical approach. Since the position of the recurrent laryngeal nerve often differs from the usual in these cases, the lymph node dissection around the recurrent laryngeal nerve, which is an important step in surgery for thoracic esophageal cancer, requires careful attention. There are some reports on the usefulness of intraoperative recurrent laryngeal nerve monitoring during esophageal cancer surgery. Herein, we report a case of successful thoracoscopic esophagectomy for esophageal cancer in a patient with a right aortic arch using intraoperative recurrent laryngeal nerve monitoring.

Case presentation
A 70-year-old man was diagnosed as having esophageal cancer (Ut, type 0-IIc, T1b/MtLt, type 0-IIc, T1b, N2, M0, cStage II) and was treated by neoadjuvant chemoradiotherapy followed by radical surgery. Preoperative CT examination revealed a right aortic arch, and based on the findings of 3D-CT, we classified the right aortic arch as type IIIB1 (Edwards classification), which is the most frequent type of right aortic arch. We performed thoracoscopic esophagectomy via a left thoracic approach with the patient placed in the prone position, cervical esophagogastric conduit reconstruction via the retrosternal route, and three-field lymph node dissection. Although Kommerell’s diverticulum could be easily confirmed, the descending aorta took a meandering course, making it difficult for the esophagus to be mobilized and detached and therefore also to identify the ductus arteriosus and left recurrent laryngeal nerve. Intraoperative recurrent laryngeal nerve monitoring using NIM-RESPONSE® 3.0 (Medtronic Japan, Tokyo, Japan) allowed the position of the left recurrent laryngeal nerve to be accurately determined, and upper mediastinal lymph node dissection and mobilization of the upper thoracic esophagus were performed safely. Postoperatively, the patient showed no evidence of recurrent laryngeal nerve palsy, but needed conservative treatment for anastomotic leakage. The patient was discharged 46 days after the surgery.

Conclusion
It was suggested that intraoperative recurrent laryngeal nerve monitoring is useful in esophageal cancer with a right aortic arch undergoing surgery, in whom anatomic abnormalities of the recurrent laryngeal nerve can be expected.
Congenital multiple colonic atresias with intestinal malrotation: a case report
Authors: Ishii Daisuke , Miyagi Hisayuki , Hirasawa Masatoshi , Miyamoto Kazutoshi 
Published: March 2020

Abstract
Background
Congenital intestinal atresia develops in 1 in 1500 to 20,000 births. Colonic atresia, which accounts for 1.8–15% of intestinal atresia cases, is accompanied by other gastrointestinal atresias such as small intestinal atresia, gastroschisis, imperforate anus, and intestinal malformation in 47–80%. Although a report shows that patients with multiple colonic atresias are 8.9% of those with colonic atresia.

Case presentation
A male infant did not have the first bowel movement within 36 h of birth and had abdominal distention/vomiting. Radiography showed significant dilation of the intestinal tract. A contrast enema examination at 3 days of age showed a microcolon and disruption in the descending colon. We performed an emergency decompressive loop enterostomy in the distended segment. At the age of 7 months, imaging from the stoma showed disruption of the contrast medium in the intestinal tract at the right lower abdomen, and the continuity of the intestinal tract was not clarified. Intestinal malrotation was found during the second surgery, and the enterostomy was located in the ileum proximal to Bauhin’s valve. Continuity of the intestinal serosal surface was maintained. However, multiple membranous obstructions (three atresias and one stenosis) were observed in the distal segment of the bowel, which was penetrated by intraluminal advancement of a urethral catheter. Therefore, he was diagnosed with multiple colonic atresias. The intestinal tract was longitudinally incised, and membranectomy and mucosal/lateral suture were performed.

Conclusions
It is important for neonates with intestinal atresia to evaluate and prepare for distal patency of the colon before radical anastomosis. In addition, anomalies associated with colon atresia should also be assessed.
Accelerated fitted operator finite difference method for singularly perturbed delay differential equations with non-local boundary condition
Authors: Debela Habtamu Garoma , Duressa Gemechis File 
Published: March 2020

AbstractIn this paper, accelerated fitted finite difference method for solving singularly perturbed delay differential equation with non-local boundary condition is considered. To treat the non-local boundary condition, Simpson’s rule is applied. The stability and parameter uniform convergence for the proposed method are proved. To validate the applicability of the scheme, two model problems are considered for numerical experimentation and solved for different values of the perturbation parameter ε and mesh size h. The numerical results are tabulated in terms of maximum absolute errors and rate of convergence, and it is observed that the present method is more accurate and ε-uniformly convergent for h ≥ ε where the classical numerical methods fails to give good result, and it also improves the results of the methods existing in the literature.
Basic safety first: trauma-informed care in a hostile environment
Authors: Bailey Cate 
Published: March 2020

SummaryThis editorial introduces and reflects on a Praxis article in the trainees' section of this issue. The article, 'Assessing asylum seekers, refugees and undocumented migrants' by Waterman et al, begins with a clinical scenario describing an emergency presentation at a ‘place of safety’. The authors are to be congratulated for navigating a compassionate path through the complexities of law, health and new diagnostic categories. The resources found in the article, drawing on the principles of trauma-informed care and the work of Judith Herman, can help trainees to be more confident in promoting the basic rights of survivors of trauma, which might form a first step in the re-establishment of trust and empowerment.
Ischemic Stroke in Young Adults
Authors: Putaala Jukka 
Published: March 2020

ABSTRACTPURPOSE OF REVIEWThis article reviews current knowledge on epidemiology, risk factors and causes, diagnostic considerations, management, and prognosis of ischemic stroke in young adults (those 55 years old and younger).RECENT FINDINGSThe incidence of ischemic stroke in young adults has been increasing since the 1980s, which has occurred in parallel with increasing prevalence of vascular risk factors and substance abuse among the younger population. Young adults have a considerably wider range of risk factors than older patients, including age-specific factors such as pregnancy/puerperium and oral contraceptive use. Behavioral risk factors such as low physical activity, excess alcohol consumption, and smoking are factors as well. More than 150 identified causes of early-onset ischemic stroke exist, including rare monogenic disorders. Several recent advances have been made in diagnosis and management of stroke in young adults, including molecular characterization of monogenic vasculitis due to deficiency of adenosine deaminase 2 and transcatheter closure of patent foramen ovale for secondary prevention. Compared with the background population of the same age and sex, long-term mortality in patients remains fourfold higher with cardiovascular causes underlying most of the deaths. The cumulative rate of recurrent stroke extends up to 15% at 10 years. Patients with atherosclerosis, high-risk sources of cardioembolism, and small vessel disease underlying their stroke seem to have the worst prognosis regarding survival and recurrent vascular events. Young stroke survivors also often have other adverse outcomes in the long term, including epilepsy, pain, cognitive problems, and depression.SUMMARYSystematic identification of risk factors and causes and the motivation of patients for long-term prevention and lifestyle changes are of utmost importance to improve the prognosis of early-onset ischemic stroke.
Management of Unruptured Cerebral Aneurysms and Arteriovenous Malformations
Authors: Ruigrok Ynte M. 
Published: March 2020

ABSTRACT

PURPOSE OF REVIEW
Unruptured intracranial aneurysms and brain arteriovenous malformations (AVMs) may be detected as incidental findings on cranial imaging. This article provides a practical approach to the management of unruptured intracranial aneurysms and unruptured brain AVMs and reviews the risk of rupture, risk factors for rupture, preventive treatment options with their associated risks, and the approach of treatment versus observation for both types of vascular malformations.

RECENT FINDINGS
For unruptured intracranial aneurysms, scoring systems on the risk of rupture can help with choosing preventive treatment or observation with follow-up imaging. Although the literature provides detailed information on the complication risks of preventive treatment of unruptured intracranial aneurysms, individualized predictions of these procedural complication risks are not yet available. With observation with imaging, growth of unruptured intracranial aneurysms can be monitored, and prediction scores for growth can help determine the optimal timing of monitoring. The past years have revealed more about the risk of complications of the different treatment modalities for brain AVMs. A randomized clinical trial and prospective follow-up data have shown that preventive interventional therapy in patients with brain AVMs is associated with a higher rate of neurologic morbidity and mortality compared with observation.

SUMMARY
The risk of hemorrhage from both unruptured intracranial aneurysms and brain AVMs varies depending on the number of risk factors associated with hemorrhage. For both types of vascular malformations, different preventive treatment options are available, and all carry risks of complications. For unruptured intracranial aneurysms, the consideration of preventive treatment versus observation is complex, and several factors should be included in the decision making. Overall, it is recommended that patients with unruptured asymptomatic brain AVMs should be observed.
Characteristics of the private public partnership mechanism main aspects in the model of a university clinic
Authors: Chopchik V. D. 
Published: March 2020

The objective: To substantiate the application of some aspects of the mechanism of public-private partnership (PPP) in the model of University Clinic (UC). Materials and methods. To achieve this goal, common scientific methods of analysis, synthesis, generalization, interpretation of scientific data, as well as systemic and structural-functional approaches were used in the work. Information base of the research was scientific works of domestic and foreign specialists on PPP. Results. The transition of Ukrainian economy to market relations requires a revision of many principles of UC organizational activity. Currently they have funding problems, which has led to a lack of high-tech equipment and technology parks for students’ training, researches conduct and population treatment. In order to solve these problems, the article considers some aspects of PPP mechanism in UC model. Conclusions. The article substantiates the use of a number of aspects of the PPP mechanism in UC model.