bluuebunny/crossref_metadata_2025_split huggingface dataset:
lncRNA-SOX2OT promotes hepatocellular carcinoma invasion and metastasis through miR-122-5p-mediated activation of PKM2
Authors: Liang Yingjian , Zhang Dandan , Zheng Tongsen , Yang Guangchao , Wang Jiabei , Meng Fanzheng , Liu Yao , Zhang Guoli , Zhang Linhan , Han Jihua , Hui Peng , Chen Zhengliang , Liu Yu , Wang Mingyu , Jiang Hongchi , Liu Lianxin 
Published: May 2020

AbstractTumor cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect, but the involvement of Warburg effect in liver cancer cell metastasis is not well understood. In present study, our results indicate a positive correlation between glucose metabolism level and metastatic potential of hepatocellular carcinoma (HCC). We also observed that a long noncoding RNA-SOX2OT (lncRNA-SOX2OT) can not only increase the metastatic potential of HCC but also promote a pyruvate kinase M2 (PKM2)-mediated activation of glucose metabolism. Inhibition of PKM2 in HCC cells greatly compromises lncRNA-SOX2OT in promoting Warburg effect and metastasis. Furthermore, miR-122-5p was found being a direct target of lncRNA-SOX2OT in regulating PKM2 expression. Thus, our findings reveal that lncRNA-SOX2OT, a regulator of PKM2, could predispose HCC patients to metastases and may serve as a candidate for metastatic prediction and therapies in HCC patients.
Non-invasive brain stimulation for posttraumatic stress disorder: a systematic review and meta-analysis
Authors: Kan Rebecca L. D. , Zhang Bella B. B. , Zhang Jack J. Q. , Kranz Georg S. 
Published: May 2020

AbstractApproximately 7–9% of people develop posttraumatic stress disorder in their lifetime, but standard pharmacological treatment or psychotherapy shows a considerable individual variation in their effectiveness. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) hold promise for the treatment of posttraumatic stress disorder. The objective of this meta-analysis was to summarize the existing evidence on the therapeutic effects of these brain stimulation treatments on posttraumatic core symptoms. We systematically retrieved articles published between 1st January 2000 and 1st January 2020 comparing the effects of active with sham stimulation or no intervention in posttraumatic patients from eight databases. Random-effects model was used for meta-analysis. Meta-regression and subgroup meta-analysis was performed to investigate the influence of stimulation dose and different stimulation protocols, respectively. 20 studies were included in this review, where of 11 randomized controlled trials were subjected to quantitative analysis. Active stimulation demonstrated significant reductions of core posttraumatic symptoms with a large effect size (Hedge’s g = −0.975). Subgroup analysis showed that both excitatory and inhibitory rTMS of the right dorsolateral prefrontal cortex led to symptom reductions with a large (Hedges’ g = −1.161, 95% CI, −1.823 to −0.499; p = 0.015) and medium effect size (Hedges’ g = −0.680, 95% CI: −0.139 to −0.322; p ≤ 0.001) respectively. Results further indicated significant durability of symptom-reducing effects of treatments during a two to four weeks period post stimulation (Hedges’ g = −0.909, 95% CI: −1.611 to −0.207; p = 0.011). rTMS of the right dorsolateral prefrontal cortex appears to have a positive effect in reducing core symptoms in patients with posttraumatic stress disorder.
Immune checkpoint signaling and cancer immunotherapy
Authors: He Xing , Xu Chenqi 
Published: May 2020

AbstractImmune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such as broad applicability across cancer types and durable clinical response when treatment is effective. However, the overall response rates are still unsatisfying, especially for cancers with low mutational burden. Moreover, adverse effects, such as autoimmune symptoms and tumor hyperprogression, present a significant downside in some clinical applications. These challenges reflect the urgent need to fully understand the basic biology of immune checkpoints. In this review, we discuss regulation of immune checkpoint signaling at multiple levels to provide an overview of our current understanding of checkpoint biology. Topics include the regulation of surface expression levels for known immune checkpoint proteins via surface delivery, internalization, recycling, and degradation. Upon reaching the surface, checkpoints engage in both conventionaltransand alsocisinteractions with ligands to induce signaling and regulate immune responses. Novel therapeutic strategies targeting these pathways in addition to classical checkpoint blockade have recently emerged and been tested in preclinical models, providing new avenues for developing next-generation immunotherapies.
Achieving Participation-Focused Intervention Through Shared Decision Making: Proposal of an Age- and Disorder-Generic Framework
Authors: Baylor Carolyn , Darling-White Meghan 
Published: May 2020

Introduction
The World Health Organization's International Classification of Functioning, Disability and Health calls on speech-language pathologists (SLPs) to provide care that impacts all aspects of an individual's experience with a communication disorder, including their participation in valued life situations. However, SLPs often report feeling unprepared to implement and document interventions that target life participation. The purpose of this article is to propose a framework to guide participation-focused intervention practices. This age- and disorder-generic framework is designed to be applicable with clients across the variety of settings in which SLPs work.

Method
In this clinical focus article, we draw on past research and clinical experience to propose a restructuring of World Health Organization's International Classification of Functioning, Disability and Health components such that participation is the primary focus and outcomes indicator for intervention. In this framework, a specific communicative participation situation is identified and assessed quantitatively, and a corresponding participation-focused goal is established through shared decision making. Following that, assessments are conducted and goals are established in the areas of communication skills, physical and social environments, and personal perspectives.

Results
The proposed framework provides a concrete organizational structure as well as assessment, goal-writing, and intervention examples to assist SLPs in translating theoretical biopsychosocial frameworks into clinical practices.

Conclusions
SLPs can and do provide holistic communication services to clients to help them achieve their life participation goals. This article provides an example as to how we can document the need for, as well as the value and impact of our important work, meeting the diverse life participation needs of clients.

Supplemental Material

https://doi.org/10.23641/asha.12360758
Pediatrician Referral Practices for Children Who Stutter
Authors: Winters Katherine L. , Byrd Courtney T. 
Published: May 2020

Purpose
Given the marked increase in evidence-based information regarding the nature/treatment of stuttering, coupled with the fact that pediatricians tend to be one of the initial points of contact for parents who suspect their preschool-age child may stutter, this study explored pediatricians' (a) accuracy in identifying children who may stutter and (b) likelihood of referring children who present with a profile indicative of stuttering to speech-language pathologists.

Method
Pediatricians recruited nationally through professional organizations completed a 5- to 7-min online survey that probed stuttering identification and referral practices via responses to experimental case vignettes. Each vignette featured a 4-year-old boy with a family history of stuttering whose mother reported signs of stuttering and manipulation of two factors: stuttering during the pediatrician visit (or not) and negative communication attitude (or not).

Results
Our findings suggest pediatricians' identification and referral of children who may stutter is largely prompted by observation of overt speech behaviors and/or negative communication attitude. Participants' gender, years in practice, and experience working with children who stutter did not influence likelihood of referral.

Conclusions
Results indicate pediatricians are less likely to implement a “wait and see” approach with young children who stutter today than in the past. Unlike other common child onset diagnoses, however, parent report of atypical behavior does not yield pediatrician referral to a specialist. Future education and advocacy efforts directed toward pediatricians should emphasize inclusion of factors other than direct observation of stuttering behavior that may warrant referral (e.g., parent report).
Maternal Input and Child Language Comprehension During Book Reading in Children With Down Syndrome
Authors: Barton-Hulsey Andrea , Lorang Emily , Renfus Kallie , Sterling Audra 
Published: May 2020

Purpose
Communication interactions between parents and children during shared book reading impact a child's development of both language and literacy skills. This study examined maternal language input and child expressive communication during a shared book reading activity in children with Down syndrome (DS) and children with typical development (TD). Additionally, children's receptive language was examined to understand the relationship between maternal language input and child receptive language ability.

Method
Participants included 22 children with DS and 22 children with TD between 22 and 63 months of age and their mothers. Each mother–child dyad participated in a 7-min naturalistic shared book reading activity.

Results
Compared to mothers of children with TD, mothers of children with DS used significantly more utterances with less grammatical complexity, but a similar range of vocabulary diversity. Mothers of children with DS used more questions, descriptions, gestures, and labels, whereas mothers of children with TD used nearly half of their utterances to read directly from books. Children with DS communicated at a similar frequency compared to their peers with TD; however, they produced significantly fewer spoken words.

Conclusions
This study reveals important differences between early shared book reading interactions and provides implications for future research targeting parent-coached intervention strategies that may enhance children's learning during shared book reading by providing access to expressive language and print instruction.
Fermi Large Area Telescope observations of the fast-dimming Crab Nebula in 60–600 MeV
Authors: Yeung Paul K. H. , Horns Dieter 
Published: May 2020

Context. The Crab pulsar and its nebula are the origin of relativistic electrons which can be observed through their synchrotron and inverse Compton emission. The transition between synchrotron-dominated and inverse-Compton-dominated emissions takes place at ≈109 eV.
Aims. The short-term (lasting for one week to months) flux variability of the synchrotron emission from the most energetic electrons is investigated with data from ten years of observations with the Fermi Large Area Telescope in the energy range from 60 MeV to 600 MeV.
Methods. We reconstructed the off-pulse light curve reconstructed from phase-resolved data. The corresponding histogram of flux measurements was used to identify distributions of flux-states and the statistical significance of a lower-flux component was estimated with dedicated simulations of mock light curves. The energy spectra for different flux states were also reconstructed.
Results. We confirm the presence of flaring-states which follow a log-normal flux distribution. Additionally, we discovered a low-flux state where the flux drops to as low as 18.4% of the intermediate-state average flux and remains there for several weeks. The transition time is observed to be as short as two days. The energy spectrum during the low-flux state resembles the extrapolation of the inverse-Compton spectrum measured at energies beyond several GeV energy, implying that the high-energy part of the synchrotron emission is dramatically depressed.
Conclusions. The low-flux state found here and the transition time of at most ten days indicate that the bulk (>75%) of the synchrotron emission above 108 eV originates in a compact volume with apparent angular size of θ ≈ 0″​​.4 tvar/(5 d). We tentatively infer that the so-called inner knot feature is the origin of the bulk of the γ-ray emission.
Collapse of spherical overdensities in superfluid models of dark matter
Authors: Hartman S. T. H. , Winther H. A. , Mota D. F. 
Published: May 2020

Aims. We intend to understand cosmological structure formation within the framework of superfluid models of dark matter with finite temperatures. Of particular interest is the evolution of small-scale structures where the pressure and superfluid properties of the dark matter fluid are prominent. We compare the growth of structures in these models with the standard cold dark matter paradigm and non-superfluid dark matter.
Methods. The equations for superfluid hydrodynamics were computed numerically in an expanding ΛCDM background with spherical symmetry; the effect of various superfluid fractions, temperatures, interactions, and masses on the collapse of structures was taken into consideration. We derived the linear perturbation of the superfluid equations, giving further insights into the dynamics of the superfluid collapse.
Results. We found that while a conventional dark matter fluid with self-interactions and finite temperatures experiences a suppression in the growth of structures on smaller scales, as expected due to the presence of pressure terms, a superfluid can collapse much more efficiently than was naively expected due to its ability to suppress the growth of entropy perturbations and thus gradients in the thermal pressure. We also found that the cores of the dark matter halos initially become more superfluid during the collapse, but eventually reach a point where the superfluid fraction falls sharply. The formation of superfluid dark matter halos surrounded by a normal fluid dark matter background is therefore disfavored by the present work.
Lösungsmöglichkeiten bei fehlgeschlagenen Osteosynthesen – Humerusschaft
Authors: Katthagen J. Christoph , Michel Philipp A. , Schliemann Benedikt , Raschke Michael J. 
Published: May 2020

ZusammenfassungBei der operativen Therapie von Humerusschaftfrakturen finden sowohl die intramedulläre Nagel- als auch die Plattenosteosynthese regelhaft Anwendung. Für beide Verfahren kann zwischen Früh- und Spätkomplikationen unterschieden werden. Bei der Nagelosteosynthese werden im frühen postoperativen Verlauf häufiger periimplantäre Frakturen etwa am Tuberculum majus oder im Bereich der Fossa olecrani beobachtet. Bei der Plattenosteosynthese hingegen kommt es häufiger zum Repositionsverlust mit sekundärer Dislokation sowie zu Affektionen des Nervus radialis. Pseudarthrosen als klassische Spätfolge zeigen sich häufiger nach der Nagelosteosynthese. Früh- und Spätinfekte im Bereich des Humerusschafts sind insgesamt selten. In der vorliegenden Arbeit werden Lösungsmöglichkeiten bei fehlgeschlagenen Osteosynthesen des Humerusschafts anhand edukativer Fallbeispiele und der aktuellen Literatur dargestellt.
Endoscopic management of gastrointestinal motility disorders – part 2: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Weusten Bas L. A. M. , Barret Maximilien , Bredenoord Albert J. , Familiari Pietro , Gonzalez Jean-Michel , van Hooft Jeanin E. , Lorenzo-Zúñiga Vicente , Louis Hubert , Martinek Jan , van Meer Suzanne , Neumann Helmut , Pohl Daniel , Prat Frederic , von Renteln Daniel , Savarino Edoardo , Sweis Rami , Tack Jan , Tutuian Radu , Ishaq Sauid 
Published: May 2020

Main RecommendationsESGE suggests flexible endoscopic treatment over open surgical treatment as first-line therapy for patients with a symptomatic Zenker’s diverticulum of any size.Weak recommendation, low quality of evidence, level of agreement 100 %.ESGE recommends that emerging treatments for Zenker’s diverticulum, such as Zenker’s peroral endoscopic myotomy (Z-POEM) and tunneling, be considered as experimental; these treatments should be offered in a research setting only.Strong recommendation, low quality of evidence, level of agreement 100 %.ESGE recommends against the widespread clinical use of transoral incisionless fundoplication (TIF) as an alternative to proton pump inhibitor (PPI) therapy or antireflux surgery in the treatment of gastroesophageal reflux disease (GERD), because of the lack of data on the long-term outcomes, the inferiority of TIF to fundoplication, and its modest efficacy in only highly selected patients. TIF may have a role for patients with mild GERD who are not willing to take PPIs or undergo antireflux surgery.Strong recommendation, moderate quality of evidence, level of agreement 92.8 %.ESGE recommends against the use of the Medigus ultrasonic surgical endostapler (MUSE) in clinical practice because of insufficient data showing its effectiveness and safety in patients with GERD. MUSE should be used in clinical trials only.Strong recommendation, low quality evidence, level of agreement 100 %.ESGE recommends against the use of antireflux mucosectomy (ARMS) in routine clinical practice in the treatment of GERD because of the lack of data and its potential complications.Strong recommendation, low quality evidence, level of agreement 100 %.ESGE recommends endoscopic cecostomy only after conservative management with medical therapies or retrograde lavage has failed.Strong recommendation, low quality evidence, level of agreement 93.3 %.ESGE recommends fixing the cecum to the abdominal wall at three points (using T-anchors, a double-needle suturing device, or laparoscopic fixation) to prevent leaks and infectious adverse events, whatever percutaneous endoscopic cecostomy method is used.Strong recommendation, very low quality evidence, level of agreement 86.7 %.ESGE recommends considering endoscopic decompression of the colon in patients with Ogilvie’s syndrome that is not improving with conservative treatment.Strong recommendation, low quality evidence, level of agreement 93.8 %.ESGE recommends prompt endoscopic decompression if the cecal diameter is > 12 cm and if the Ogilvie’s syndrome exists for a duration of longer than 4 – 6 days.Strong recommendation, low quality evidence, level of agreement 87.5 %.
Study of the distribution of different types of cleft lip and palate and associated anomalies
Authors: Barman Alpana , Dutta B C , Sarkar J K 
Published: May 2020

Abstract
Background : Cleft lip and palate are some of the most common congenital deformities. They frequently occur as isolated deformities, but can be associated with other medical conditions and anomalies. Aim of the study: To study the distribution of different types of cleft lip and palate and associated anomalies. Materials and methods: Forty patients of cleft lip and palate were studied. Relevant history was taken, clinical examination done and recorded with photography with consent. The cases were classified as per Nagpur Classification. Results: In our study 24 cases (60%) were cleft lip and palate (type III) and 10 cases (25%) of cleft palate alone (type II) and 6 cases (15%) of cleft lip alone (type I). Males were found to predominate in type I and III. Females predominated in type II. Among the cleft lip, left side is found to be involved in most of the cases. In our study, out of 40 cases, 8 cases (20%) had other associated anomalies. Most of these were associated with cleft lip and palate (type III) and isolated cleft palate (type II). Conclusion: The typical universal distribution of cleft types and associated anomalies tallies with our results.
A Novel Hypomorphic CSF1R Gene Mutation in the Biallelic State Leading to Fatal Childhood Neurodegeneration
Authors: Tamhankar Parag Mohan , Zhu Bin , Tamhankar Vasundhara Parag , Mithbawkar Shilpa , Seabra Luis , Livingston John H. , Ikeuchi Takeshi , Crow Yanick J. 
Published: May 2020

AbstractWe report the clinical and molecular characterization of a novel biallelic mutation in the CSF1R gene leading to an autosomal recessive form of childhood onset leukoencephalopathy in a consanguineous family. The female child experienced acute encephalopathy at the age of 2 years, followed by spasticity and loss of all achieved milestones over 6 months. Her elder brother presented with encephalopathy at 4 years of age, with a subsequent loss of all achieved milestones over 8 months. Brain imaging in both children revealed multiple well-defined areas of calcification in the parietal and frontal regions and the occipital horns of both lateral ventricles. Clinical exome trio analysis showed homozygosity for a p.T833M mutation in CSF1R in the girl. Heterozygous family members, including both parents, were asymptomatic, with the eldest being 68 years of age. Total CSF1R protein expression levels were normal as compared with wild-type allele, but CSF1 ligand dependent autophosphorylation was consistent with a hypomorphic allele.
Microarray-Based Comparative Genomic Hybridization, Multiplex Ligation-Dependent Probe Amplification, and High-Resolution Karyotype for Differential Diagnosis Oculoauriculovertebral Spectrum: A Systematic Review
Authors: Glaeser Andressa Barreto , Diniz Bruna Lixinski , Deconte Desirée , Santos Andressa Schneiders , Rosa Rafael Fabiano Machado , Zen Paulo Ricardo Gazzola 
Published: May 2020

AbstractOculoauriculovertebral spectrum (OAVS) is a rare class of heterogenous congenital craniofacial malformation conditions of unknown etiology. Although classic OAVS has been described as hemifacial microsomia with facial asymmetry and microtia, there is no consensus regarding clinical criteria for diagnosis or genetic cause. This systematic review aims to assess the applicability of high-resolution (HR) karyotype, fluorescence in situ hybridization, multiplex ligation-dependent probe amplification (MLPA), and microarray-based comparative genomic hybridization (array-CGH) for differential diagnosis of OAVS. A search was performed in PubMed and Web of Science using all entry terms to the following descriptors: Goldenhar's syndrome, cytogenetic analysis, hybridization in situ, fluorescent, comparative genomic hybridization, multiplex polymerase chain reaction, whole genome sequencing, and karyotype analysis methods. After screening, 25 articles met eligibility. Of the included studies, 59 individuals had a genetic alteration identified. Array-CGH, MLPA, and HR karyotype appear to be viable approaches for molecular diagnosis in OAVS. Heterogeneity is a hallmark of OAVS. Establishing an enhanced framework for diagnosis would inform clinical decision making, and better resource utilization could improve health care facility efficiency and economy.