bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cold tolerance in the genusArabidopsis
Authors: Armstrong Jessica J. , Takebayashi Naoki , Wolf Diana E. 
Published: February 2020

PremiseCold tolerance is an important factor limiting the geographic distribution and growing season for many plant species, yet few studies have examined variation in cold tolerance extensively within and among closely related species and compared that to their geographic distribution.MethodsThis study examines cold tolerance within and among species in the genusArabidopsis. We assessed cold tolerance by measuring electrolyte leakage from detached leaves in multiple populations of fiveArabidopsistaxa. The temperature at which 50% of cells were lysed was considered the lethal temperature (LT50).ResultsWe found variability within and among taxa in cold tolerance. There was no significant within‐species relationship between latitude and cold tolerance. However, the northern taxa,A. kamchatica,A. lyratasubsp.petraea, andA. lyratasubsp.lyrata, were more cold tolerant thanA. thalianaandA. hallerisubsp.gemmiferaboth before and after cold acclimation. Cold tolerance increased after cold acclimation (exposure to low, but nonfreezing temperatures) for all taxa, although the difference was not significant forA. hallerisubsp.gemmifera. For all taxa exceptA. lyratasubsp.lyrata, theLT50values for cold‐acclimated plants were higher than the January mean daily minimum temperature (Tmin), indicating that if plants were not insulated by snow cover, they would not likely survive winter at the northern edge of their range.ConclusionsArabidopsis lyrataandA. kamchaticawere far more cold tolerant thanA. thaliana. These extremely cold‐tolerant taxa are excellent candidates for studying both the molecular and ecological aspects of cold tolerance.
Flexible polymer thermoelectric device based on PEDOT:PSS and surface treated pyromellitic dianhydride‐oxydianiline polyimide substrate
Authors: Lee Juheon , Kim Seohyun , Chung Moonhyun , Jeong Hakgeun , Choi Hyanghee , Han Haksoo 
Published: February 2020

AbstractFlexible polymer thermoelectric devices based on poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and pyromellitic dianhydride‐oxydianiline polyimide polyimide (PI) were fabricated and investigated in this work. PI was selected as a substrate for PEDOT:PSS to secure from repeated bending cycles of flexible device. To enhance the interfacial adhesion between PEDOT:PSS and PI, oxygen plasma treatment was used on the surface of PI substrate. The effect of the surface treatment with oxygen plasma on the synthesized PI substrate was significant. The polar component of surface free energy of PI was increased from 2.8 to 31.8 mJ/m2. The power factor of PEDOT:PSS on the PI substrate was increased from 25.86 to 43.78 μW m−1 K−2. Also, as a result of 10 k times of bending test, the electrical performance consistency and the mechanical stability of the fabricated devices were confirmed. This verified fabricated flexible polymer thermoelectric devices based on PEDOT:PSS and PI are suitable for the various applications.
Treatment times in breast cancer patients receiving neoadjuvant vs adjuvant chemotherapy: Is efficiency a benefit of preoperative chemotherapy?
Authors: Melchior Nicole M. , Sachs Darren B. , Gauvin Gabrielle , Chang Cecilia , Wang Chihsiung E. , Sigurdson Elin R. , Daly John M. , Aggon Allison A. , Hayes Shelly B. , Obeid Elias I. , Bleicher Richard J. 
Published: February 2020

AbstractBackground/ObjectiveDelays in times to surgery, chemotherapy, and radiotherapy impair survival in breast cancer patients. Neoadjuvant chemotherapy (NAC) confers equivalent survival to adjuvant chemotherapy (AC), but it remains unknown which approach facilitates faster initiation and completion of treatment.MethodsWomen ≥18 years old with nonrecurrent, noninflammatory, clinical stage I‐III breast cancer diagnosed between 2004 and 2015 who underwent both surgery and chemotherapy were reviewed from the National Cancer Database.ResultsAmong 155 606 women overall, 28 241 patients received NAC and 127 365 patients received AC. NAC patients had higher clinical T and N stages (35.8% T3/4 vs 4.9% T3/4; 14.4% N2/3 vs 3.7% N2/3). After adjusting for stage and other factors, NAC patients had longer times to begin treatment (36.1 vs 35.4 days adjusted, P = .15), and took significantly longer to start radiotherapy (240.8 vs 218.2 days adjusted, P < .0001), and endocrine therapy (301.6 vs 275.7 days adjusted, P < .0001). Unplanned readmissions (1.2% vs 1.7%), 30‐day mortality (0.04% vs 0.01%), and 90‐day mortality (0.30% vs 0.08%) were all low and clinically insignificant between NAC and AC.ConclusionCompared to patients receiving AC, those receiving NAC do not start treatment sooner. In addition, patients receiving NAC do not complete treatment faster. Although there are clear indications for administering NAC vs AC, rapidity of treatment should not be considered a benefit of giving chemotherapy preoperatively.
Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma
Authors: Kondo Sayuri , Ota Akinobu , Ono Takayuki , Karnan Sivasundaram , Wahiduzzaman Md , Hyodo Toshinori , Lutfur Rahman Md , Ito Kunihiro , Furuhashi Akifumi , Hayashi Tomio , Konishi Hiroyuki , Tsuzuki Shinobu , Hosokawa Yoshitaka , Kazaoka Yoshiaki 
Published: February 2020

AbstractAmeloblastoma is a rare odontogenic benign tumor accounting for less than 1% of head and neck tumors. Advanced next generation sequencing (NGS) analyses identified high frequency of BRAF V600E and SMO L412F mutations in ameloblastoma. Despite the existence of whole genomic sequence information from patients with ameloblastoma, entire molecular signature of and the characteristics of ameloblastoma cells are still obscure. In this study, we sought to uncover the molecular basis of ameloblastoma and to determine the cellular phenotype of ameloblastoma cells with BRAF mutations. Our comparative cDNA microarray analysis and gene set enrichment analysis (GSEA) showed that ameloblastoma exhibited a distinct gene expression pattern from the normal tissues: KRAS‐responsive gene set is significantly activated in ameloblastoma. Importantly, insulin like growth factor 2 (IGF2), a member of KRAS‐responsive genes, enhances the proliferation of an ameloblastoma cell line AMU‐AM1 with BRAF mutation. In addition, Toll‐like receptor 2 (TLR2) knockdown readily inactivated KRAS‐responsive gene sets as well as increases caspase activities, suggesting that TLR2 signaling may mediate cell survival signaling in ameloblastoma cells. Collectively, the findings may help to further clarify the pathophysiology of ameloblastoma and lead to the development of precision medicine for patients with ameloblastoma.
CD66b+ neutrophils and α‐SMA+ fibroblasts predict clinical outcomes and benefits from postoperative chemotherapy in gastric adenocarcinoma
Authors: Cong Xiliang , Zhang Yongle , Zhu Ziyu , Li Sen , Yin Xin , Zhai Zhao , Zhang Yu , Xue Yingwei 
Published: February 2020

AbstractBackgroundEmerging evidence indicates that the tumor microenvironment (TME) influences tumor progression through the various cells it contains. Tumor‐associated neutrophils (TANs) and cancer‐associated fibroblasts (CAFs) are prominent constituents of diverse malignant solid tumors and are crucial in the TME and cancer evolution. However, the relationships and combined prognostic value of these two cell types are not known in gastric adenocarcinoma (GAC).Materials and MethodsIn total, 215 GAC patients who underwent curative surgery were enrolled. TANs were assessed by immunohistochemical staining for CD66b, and CAFs were evaluated by immunohistochemical staining for α‐smooth muscle actin (α‐SMA).ResultsThe percentages of patients with high‐density TANs and CAFs in GAC tissue were 47.9% (103/215) and 43.3% (93/215), respectively. The densities of TANs and CAFs in GAC tissue samples were markedly elevated and independently correlated with GAC clinical outcomes. A strong correlation (R = .348, P < .001) was detected between TANs and CAFs in GAC. The combination of TANs and CAFs produced a more exact outcome than either factor alone. Patients with an α‐SMAlowCD66bhigh (hazard ratio [HR] = 1.791; 95% CI: 1.062‐3.021; P = .029), α‐SMAhighCD66blow (HR = 2.402; 95% CI: 1.379‐4.183; P = .002), or α‐SMAhighCD66bhigh (HR = 3.599; 95% CI: 2.330‐5.560; P < .001) phenotype were gradually correlated with poorer disease‐free survival than the subset of patients with an α‐SMAlowCD66blow phenotype. The same results were observed for disease‐specific survival in the subgroups. Noticeably, in stage II‐III patients with the α‐SMAlowCD66blow phenotype, an advantage was obtained with postoperative chemotherapeutics, and the risk of a poor prognosis was reduced compared with stage II‐III patients with the α‐SMAlowCD66bhigh, α‐SMAhighCD66blow or α‐SMAhighCD66bhigh phenotype (HR: 0.260, 95% CI: 0.124‐0.542, P < .001 for disease‐free survival; and HR: 0.258, 95% CI: 124‐0.538, P < .001 for disease‐specific survival).ConclusionOverall, we concluded that the combination of CD66b+ TANs and α‐SMA+ CAFs could be used as an independent factor for patient outcomes and to identify GAC patients who might benefit from the administration of postoperative chemotherapeutics.
Embedding Industry Certifications into Community College Programs
Authors: McCaffery Russell N. , Backus Leslie , Maxwell Nan 
Published: February 2020

AbstractThis chapter discusses the process Broward College in Fort Lauderdale, Florida used to embed certifications from the Council of Supply Chain Management Professionals into its associate and bachelor degree programs. Included is an overview of the process followed as well as challenges encountered. The chapter concludes with recommendations for institutions that are looking to embed third‐party industry certifications into their academic programs.
Membrane Distillation of Butanol from Aqueous Solution with Polytetrafluoroethylene Membrane
Authors: Wang Yuyang , Qiu Boya , Fan Senqing , Liu Jingyun , Qin Yangmei , Jian Shizhao , Wang Yinan , Xiao Zeyi 
Published: February 2020

AbstractNowadays, butanol is considered as biofuel. In this work, separation of butanol from aqueous solution was carried out by vacuum membrane distillation with polytetrafluoroethylene membrane, using mechanical vapor compression on the downstream. Higher flow rates could promote membrane separation with higher total flux and higher separation factor, thus influencing butanol separation. Membrane fouling was observed which exerted a substantial effect on the membrane separation performance with a real fermentation broth. Compared to the traditional distillation process, this procedure is more cost‐effective due to ∼ 50 % reduced energy consumption.
Evaluation of Scale and Corrosion Inhibition of Modified Polyaspartic Acid
Authors: Chen Jianxin , Chen Fengjiang , Han Jian , Su Min , Li Yinhui 
Published: February 2020

AbstractAmino acid modified polyaspartic acids were evaluated as calcium‐scale inhibitors. Feasibility of scale inhibition experiments was analyzed by molecular dynamics simulation and Gaussian optimization, and the scale inhibition mechanism was theoretically analyzed. Scale inhibition performance was studied by scanning electron microscopy, X‐ray diffraction, X‐ray photoelectron spectroscopy, static scale inhibition experiments, and electrochemical performance testing, which provided an experimental basis for the molecular dynamics simulation. The experimental results showed that Arg‐SA‐PASP has better scale inhibition and corrosion inhibition performance than His‐SA‐PASP. The scale inhibition effect increased with increasing concentration. Electrochemical tests indicated that Arg‐SA‐PASP is an excellent scale and corrosion inhibitor.
Influence of the Mineral Content on the Emissivity of Hydrothermal Char
Authors: Graeser Philipp , Pörtner Lukas , Schiemann Martin 
Published: February 2020

AbstractThe influence of minerals on solid fuel conversion is an important topic and has so far been addressed focusing mainly on the catalytic effects. Here, the impact of iron oxide on the emissivity of burning char particles was investigated. Synthetic, hydrothermally carbonized char was doped with SiO2 or with a mixture of SiO2 and Fe2O3. The sample was then exposed to an oxy‐fuel atmosphere in a laboratory reactor. An established pyrometer/infrared (IR) spectrometer setup was used to measure the size, temperature, and IR radiation of single burning particles. Based on these measurements, the spectral and total emissivity in the near‐IR (1.25–2.25 μm) and the total emissivity in the mid‐IR region (2.4–5.5 μm) were calculated. The results show that the iron content directly influences the emissivity of char during combustion.
Review of thermo‐kinetic correlation during grain growth in nanocrystalline materials
Authors: Peng Haoran , Jian Zengyun , Liu Feng 
Published: February 2020

AbstractNanocrystalline (NC) materials exhibit many unique properties over their coarse‐grained counterparts due to the high grain boundary density and the small grain size, but they are too difficult to be used in engineering environment because of the poor thermal stability. With regard of this, two strategies are previously proposed to enhance the thermal stability (or impede the grain growth) of NC materials, that is, the thermodynamic and the kinetic approaches. Recent investigations increasingly support that the two approaches may be physically interacted and acted on each other, and they can be treated together within a unified thermo‐kinetic framework. This paper reviews the progress in the investigation of thermo‐kinetic correlation during grain growth in NC materials. First, the theoretical models to describe the concept of the thermo‐kinetic correlation and the grain growth equations developed based on the thermo‐kinetic correlation are reviewed. Second, experimental and simulated evidences to support the coexistence of thermodynamic and kinetic effects are summarized. Third, the potential application of thermo‐kinetic correlation is analyzed and discussed. This paper shows that the stabilization of NC materials can be tailored by the selection of the suitable strategies. Finally, several directions that require further exploration are identified.
Tunable Ni/Fe‐Mo carbide catalyst with high activity toward hydrogen evolution reaction
Authors: Wang Channa , Li Ling , Wang Huihua , Qu Tianpeng , Tian Jun , Wang Deyong , Kang Zhenhui 
Published: February 2020

AbstractCost‐effective catalysts for hydrogen evolution reaction (HER) are attractive for sustainable production of H2 fuel. Herein, a series of tunable Ni/Fe‐Mo carbide catalysts have been synthesized via a sol‐gel method coupling with a subsequent high temperature carbonization process. The amount of nickel and iron was tuned in the Mo7/C precursors, accomplishing a favourable performance of noble‐metal‐free electrocatalysts for HER. As expected, the designed Ni10Fe4Mo7/C catalyst displays an enhanced catalytic activity toward hydrogen production with an ultralow overpotential (η10 = 110 mV) and striking kinetics (ηonset = 58 mV, k = 54 mV · dec−1) in the alkaline electrolyte (1 M KOH), which are comparable to those of the commercial 20% Pt/C catalyst. Such excellent performance of Ni10Fe4Mo7/C could be attributed to the high intrinsic activities of Ni‐based alloys (NiMo4) and Mo2C, as well as to the lattice contraction in the Mo2C unit cell, in accordance with its high electrochemical surface area (~133 m2 · g−1) and low charge‐transfer resistance (~31.5 Ω) for the associated electrode.
Outcomes and toxicities of definitive radiotherapy and reirradiation using 3‐dimensional conformal or intensity‐modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies
Authors: Fan Ming , Kang Jung Julie , Lee Anna , Fan Dan , Wang Huili , Kitpanit Sarin , Fox Pamela , Sine Kevin , Mah Dennis , McBride Sean M. , Tsai Chiaojung Jillian , Riaz Nadeem , Dunn Lara A. , Sherman Eric J. , Michel Loren , Singh Bhuvanesh , Ganly Ian , Wong Richard J. , Boyle Jay O. , Cohen Marc A. , Lee Nancy Y. 
Published: February 2020

BackgroundProton therapy (PT) improves outcomes in patients with nasal cavity (NC) and paranasal sinus (PNS) cancers. Herein, the authors have reported to their knowledge the largest series to date using intensity‐modulated proton therapy (IMPT) in the treatment of these patients.MethodsBetween 2013 and 2018, a total of 86 consecutive patients (68 of whom were radiation‐naive and 18 of whom were reirradiated) received PT to median doses of 70 grays and 67 grays relative biological effectiveness, respectively. Approximately 53% received IMPT.ResultsThe median follow‐up was 23.4 months (range, 1.7‐69.3 months) for all patients and 28.1 months (range, 2.3‐69.3 months) for surviving patients. The 2‐year local control (LC), distant control, disease‐free survival, and overall survival rates were 83%, 84%, 74%, and 81%, respectively, for radiation‐naive patients and 77%, 80%, 54%, and 66%, respectively for reirradiated patients. Among radiation‐naive patients, when compared with 3‐dimensional conformal proton technique, IMPT significantly improved LC (91% vs 72%; P < .01) and independently predicted LC (hazard ratio, 0.14; P = .01). Sixteen radiation‐naive patients (24%) experienced acute grade 3 toxicities; 4 (6%) experienced late grade 3 toxicities (osteoradionecrosis, vision loss, soft‐tissue necrosis, and soft tissue fibrosis) (grading was performed according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 5.0]). Slightly inferior LC was noted for patients undergoing reirradiation with higher complications: 11% experienced late grade 3 toxicities (facial pain and brain necrosis). Patients treated with reirradiation had more grade 1 to 2 radionecrosis than radiation‐naive patients (brain: 33% vs 7% and osteoradionecrosis: 17% vs 3%).ConclusionsPT achieved remarkable LC for patients with nasal cavity and paranasal sinus cancers with lower grade 3 toxicities relative to historical reports. IMPT has the potential to improve the therapeutic ratio in these malignancies and is worthy of further investigation.
A review on solar forecasting and power management approaches for energy‐harvesting wireless sensor networks
Authors: Sharma Amandeep , Kakkar Ajay 
Published: February 2020

SummaryFor rechargeable wireless sensor nodes, effective power management is of prime importance because of the stochastic behaviour of the environmental resources. A key issue in integrating solar resources with wireless sensor networks (WSNs) is the need of precise irradiance measurements and power to resource modelling. WSNs are employed in an adhoc manner comprises of numerous sensing nodes and organised as a network for the sake of checking and balancing the environmental factors. Each node has sensing, computation, communication, and locomotion capabilities but operates with limited battery life. Energy harvesting is a way of powering these WSNs by harvesting energy from the environment. By considering harvested energy as an energy source, certain considerations are different from that of battery‐operated networks. Nondeterministic energy availability with respect to time is the reason behind these differences, which put a limit on the maximum rate at which energy can be used. Thus, reliable knowledge of solar radiation is essential for informed design, deployment planning, and optimal management of energy in rechargeable WSNs. Further, power management is essential in self‐powerssed networks to efficiently utilize the available energy. In this paper, a detailed survey on different solar forecasting techniques has been presented for precise energy estimates. A detailed study on energy efficient power management techniques is also proposed to address the feasibility of energy‐harvesting approach in WSNs.
Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway
Authors: Xiao Feng , Ouyang Binshen , Zou Jue , Yang Yelin , Yi Lina , Yan Hongzhu 
Published: February 2020

AbstractObjectiveTo study the relationship between TRIM14 expression and chemotherapy resistance of gastric cancer (GC) cells.MethodsThe expression of TRIM14 in 5‐fluorouracil (5‐FU)‐ and oxaliplation (L‐OHP)‐resistant GC tissues and cells were determined by qRT‐PCR and western blotting. PcDNA3.1‐TRIM14 and shRNA‐TRIM14 vector were transfected to 5‐FU‐resistant GC cells (SGC7901/5‐FU), and the proliferation and apoptosis of cells were measured. Animal experiments on 5‐FU‐resistant GC mice were performed to study the effect of TRIM14 expression on tumor size and weight, GC cell migration, and proliferation. pcDNA3.1‐MK‐3903 plasmid was transfected to SGC7901/5‐FU cells with TRIM14 silence. The cell proliferation and apoptosis were determined. The protein expressions of Trim14, LC3, and BECLIN1 were measured by western blotting.ResultsTRIM14 was significantly upregulated in 5‐FU‐ and L‐OHP‐resistant GC tissues and cells. The overexpression of TRIM14 promoted the proliferation and autophagy of SGC7901/5‐FU cells, and inhibited the apoptosis. Moreover, in vivo experiment verified that the silence of TRIM14 reduced the tumor size and weight, and inhibited the migration and proliferation of GC cells in 5‐FU‐resistant GC mice. The overexpression of MK‐3903 reversed the inhibiting role of TRIM14 knockout on the proliferation and autophagy of SGC7901/5‐FU cells.ConclusionTRIM14 promoted chemotherapy resistance of GC cells by regulating AMPK/mTOR pathway, and may be a new biomarker for treating GC.
Neuron–glia interaction in the Drosophila nervous system
Authors: Bittern Jonas , Pogodalla Nicole , Ohm Henrike , Brüser Lena , Kottmeier Rita , Schirmeier Stefanie , Klämbt Christian 
Published: February 2020

AbstractAnimals are able to move and react in manifold ways to external stimuli. Thus, environmental stimuli need to be detected, information must be processed, and, finally, an output decision must be transmitted to the musculature to get the animal moving. All these processes depend on the nervous system which comprises an intricate neuronal network and many glial cells. Glial cells have an equally important contribution in nervous system function as their neuronal counterpart. Manifold roles are attributed to glia ranging from controlling neuronal cell number and axonal pathfinding to regulation of synapse formation, function, and plasticity. Glial cells metabolically support neurons and contribute to the blood–brain barrier. All of the aforementioned aspects require extensive cell–cell interactions between neurons and glial cells. Not surprisingly, many of these processes are found in all phyla executed by evolutionarily conserved molecules. Here, we review the recent advance in understanding neuron–glia interaction in Drosophila melanogaster to suggest that work in simple model organisms will shed light on the function of mammalian glial cells, too.