bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galactic population of black holes in detached binaries with low-mass stripped helium stars: the case of LB-1 (LS V+22 25)
Authors: Yungelson L R , Kuranov A G , Postnov K A , Kolesnikov D A 
Published: April 2020

ABSTRACT
We model the Galactic population of detached binaries that harbour black holes with 0.5–1.7 M⊙ companions – remnants of case B mass exchange that rapidly cross Hertzsprung gap after the termination of the Roche lobe overflow or as He-shell burning stars. Several such binaries can be currently present in the Galaxy. The range of MBH in them is about 4–10 M⊙, and the orbital periods are tens to hundreds of days. The unique black hole binary LB-1 fits well into this extremely rare class of double stars.
BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization
Authors: Taverna Federico , Goveia Jermaine , Karakach Tobias K , Khan Shawez , Rohlenova Katerina , Treps Lucas , Subramanian Abhishek , Schoonjans Luc , Dewerchin Mieke , Eelen Guy , Carmeliet Peter 
Published: April 2020

Abstract
The amount of biological data, generated with (single cell) omics technologies, is rapidly increasing, thereby exacerbating bottlenecks in the data analysis and interpretation of omics experiments. Data mining platforms that facilitate non-bioinformatician experimental scientists to analyze a wide range of experimental designs and data types can alleviate such bottlenecks, aiding in the exploration of (newly generated or publicly available) omics datasets. Here, we present BIOMEX, a browser-based software, designed to facilitate the Biological Interpretation Of Multi-omics EXperiments by bench scientists. BIOMEX integrates state-of-the-art statistical tools and field-tested algorithms into a flexible but well-defined workflow that accommodates metabolomics, transcriptomics, proteomics, mass cytometry and single cell data from different platforms and organisms. The BIOMEX workflow is accompanied by a manual and video tutorials that provide the necessary background to navigate the interface and get acquainted with the employed methods. BIOMEX guides the user through omics-tailored analyses, such as data pretreatment and normalization, dimensionality reduction, differential and enrichment analysis, pathway mapping, clustering, marker analysis, trajectory inference, meta-analysis and others. BIOMEX is fully interactive, allowing users to easily change parameters and generate customized plots exportable as high-quality publication-ready figures. BIOMEX is open source and freely available at https://www.vibcancer.be/software-tools/biomex.
Dengue virus targets RBM10 deregulating host cell splicing and innate immune response
Authors: Pozzi Berta , Bragado Laureano , Mammi Pablo , Torti María Florencia , Gaioli Nicolás , Gebhard Leopoldo G , García Solá Martín E , Vaz-Drago Rita , Iglesias Néstor G , García Cybele C , Gamarnik Andrea V , Srebrow Anabella 
Published: April 2020

Abstract
RNA-seq experiments previously performed by our laboratories showed enrichment in intronic sequences and alterations in alternative splicing in dengue-infected human cells. The transcript of the SAT1 gene, of well-known antiviral action, displayed higher inclusion of exon 4 in infected cells, leading to an mRNA isoform that is degraded by non-sense mediated decay. SAT1 is a spermidine/spermine acetyl-transferase enzyme that decreases the reservoir of cellular polyamines, limiting viral replication. Delving into the molecular mechanism underlying SAT1 pre-mRNA splicing changes upon viral infection, we observed lower protein levels of RBM10, a splicing factor responsible for SAT1 exon 4 skipping. We found that the dengue polymerase NS5 interacts with RBM10 and its sole expression triggers RBM10 proteasome-mediated degradation. RBM10 over-expression in infected cells prevents SAT1 splicing changes and limits viral replication, while its knock-down enhances the splicing switch and also benefits viral replication, revealing an anti-viral role for RBM10. Consistently, RBM10 depletion attenuates expression of interferon and pro-inflammatory cytokines. In particular, we found that RBM10 interacts with viral RNA and RIG-I, and even promotes the ubiquitination of the latter, a crucial step for its activation. We propose RBM10 fulfills diverse pro-inflammatory, anti-viral tasks, besides its well-documented role in splicing regulation of apoptotic genes.
Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop ‘G4 Kissing’ interaction
Authors: Williams Jonathan D , Houserova Dominika , Johnson Bradley R , Dyniewski Brad , Berroyer Alexandra , French Hannah , Barchie Addison A , Bilbrey Dakota D , Demeis Jeffrey D , Ghee Kanesha R , Hughes Alexandra G , Kreitz Naden W , McInnis Cameron H , Pudner Susanna C , Reeves Monica N , Stahly Ashlyn N , Turcu Ana , Watters Brianna C , Daly Grant T , Langley Raymond J , Gillespie Mark N , Prakash Aishwarya , Larson Erik D , Kasukurthi Mohan V , Huang Jingshan , Jinks-Robertson Sue , Borchert Glen M 
Published: April 2020

AbstractMammalian antibody switch regions (∼1500 bp) are composed of a series of closely neighboring G4-capable sequences. Whereas numerous structural and genome-wide analyses of roles for minimal G4s in transcriptional regulation have been reported, Long G4-capable regions (LG4s)—like those at antibody switch regions—remain virtually unexplored. Using a novel computational approach we have identified 301 LG4s in the human genome and find LG4s prone to mutation and significantly associated with chromosomal rearrangements in malignancy. Strikingly, 217 LG4s overlap annotated enhancers, and we find the promoters regulated by these enhancers markedly enriched in G4-capable sequences suggesting G4s facilitate promoter-enhancer interactions. Finally, and much to our surprise, we also find single-stranded loops of minimal G4s within individual LG4 loci are frequently highly complementary to one another with 178 LG4 loci averaging &gt;35 internal loop:loop complements of &gt;8 bp. As such, we hypothesized (then experimentally confirmed) that G4 loops within individual LG4 loci directly basepair with one another (similar to characterized stem–loop kissing interactions) forming a hitherto undescribed, higher-order, G4-based secondary structure we term a ‘G4 Kiss or G4K’. In conclusion, LG4s adopt novel, higher-order, composite G4 structures directly contributing to the inherent instability, regulatory capacity, and maintenance of these conspicuous genomic regions.
Comaneci-Assisted Coiling as a Treatment Option for Acutely Ruptured Wide Neck Cerebral Aneurysm: Case Series of 118 Patients
Authors: Sirakov Alexander , Minkin Krasimir , Penkov Marin , Ninov Kristian , Karakostov Vasil , Sirakov Stanimir 
Published: April 2020

Abstract

Background
Wide-necked cerebral aneurysms in the setting of acute subarachnoid hemorrhage (SAH) remain difficult to treat with endovascular methods despite recent progress in the neuroendovascular field.

Objective
To evaluate the effectiveness and safety of the Comaneci device (Rapid Medical, Israel) in endovascular coil embolization of acutely ruptured, wide-necked sidewall, or bifurcation cerebral aneurysms.

Methods
We retrospectively reviewed 45 anterior communicating artery, 24 internal carotid artery, 21 middle cerebral artery bifurcation, 15 anterior cerebral artery, and 13 posterior circulation aneurysms, which were treated using Comaneci-assisted coil embolization from August 2017 to January 2019. We evaluated procedural complications, clinical outcomes, and mid-term angiographic follow-up. Immediate and 90 d-clinical outcome and radiological follow-up were obtained in all patients.

Results
Comaneci-assisted coil embolization was performed in 118 acutely ruptured aneurysms. The technique was carried out successfully in all cases. Simultaneous application of 2 separated Comaneci devices was performed in 8/118 cases (6.77%). Periprocedural thromboembolic complications related to the device were seen in 7/118 cases (5.93%) and severe vasospasm of the parent artery after manipulation of the Comaneci device occurred in 5/118 cases (4.2%). The procedural-related morbidity rate was 2.54%, and there was no procedural related mortality. Among the available survivors, angiographic follow-ups were obtained at 3 and 6 mo, and complete aneurysmal obliteration was confirmed in 81/112 (72.3%) and 75/112 (66.9%) cases, respectively. Mid-term follow-up reviewed total recanalization rate of 14.28%.

Conclusion
Comaneci-assisted embolization of wide-necked intracranial aneurysms in patients presenting with acute SAH is associated with high procedural safety and adequate occlusion rates. Furthermore, dual antiplatelet therapy can be safely avoided in this patient group.
Correlating the electronic structures of metallic/semiconducting MoTe2 interface to its atomic structures
Authors: Han Bo , Yang Chen , Xu Xiaolong , Li Yuehui , Shi Ruochen , Liu Kaihui , Wang Haicheng , Ye Yu , Lu Jing , Yu Dapeng , Gao Peng 
Published: April 2020

Abstract
Contact interface properties are important in determining the performances of devices that are based on atomically thin two-dimensional (2D) materials, especially for those with short channels. Understanding the contact interface is therefore important to design better devices. Herein, we use scanning transmission electron microscopy, electron energy loss spectroscopy, and first-principles calculations to reveal the electronic structures within the metallic (1T′)-semiconducting (2H) MoTe2 coplanar phase boundary across a wide spectral range and correlate its properties to atomic structures. We find that the 2H-MoTe2 excitonic peaks cross the phase boundary into the 1T′ phase within a range of approximately 150 nm. The 1T′-MoTe2 crystal field can penetrate the boundary and extend into the 2H phase by approximately two unit-cells. The plasmonic oscillations exhibit strong angle dependence, that is a red-shift of π+σ (approximately 0.3–1.2 eV) occurs within 4 nm at 1T′/2H-MoTe2 boundaries with large tilt angles, but there is no shift at zero-tilted boundaries. These atomic-scale measurements reveal the structure–property relationships of the 1T′/2H-MoTe2 boundary, providing useful information for phase boundary engineering and device development based on 2D materials.
The Gay Cake Case: What the Supreme Court Did, and Didn’t, Decide in Ashers
Authors: McCrudden Christopher 
Published: April 2020

Abstract
The Supreme Court got it right in the Ashers (‘Gay cake’) case. It decided correctly the important legal issues central to the case: the scope of indissociability; the scope of ‘associative’ discrimination in sexual orientation goods and services discrimination claims; whose characteristics are relevant for determining whether an action amounts to unlawful discrimination; and the extent of the protection which freedom of expression accords individual service providers and companies from ‘forced’ or ‘compelled’ political and religious expression. Much of the critical commentary that followed the case is overblown. In some respects, the case is somewhat less legally significant, and less legally controversial, than the commentary would suggest. Underlying some of the resistance to the decision is a sense that the Court should have manipulated the legal test of unlawful discrimination to reach a morally satisfying result. This is not how the Court should decide such cases, leading as it does to a severe rupture with the idea of legality and the Rule of Law. In any event, the three (moral) arguments that are drawn on—dignity, equality, and conscience-scepticism—are less helpful that might appear in addressing Ashers-type cases, and do not undermine the normative foundations of the Supreme Court's decision.
ALMA CO observations of a giant molecular cloud in M 33: Evidence for high-mass star formation triggered by cloud–cloud collisions
Authors: Sano Hidetoshi , Tsuge Kisetsu , Tokuda Kazuki , Muraoka Kazuyuki , Tachihara Kengo , Yamane Yumiko , Kohno Mikito , Fujita Shinji , Enokiya Rei , Rowell Gavin , Maxted Nigel , Filipović Miroslav D , Knies Jonathan , Sasaki Manami , Onishi Toshikazu , Plucinsky Paul P , Fukui Yasuo 
Published: April 2020

AbstractWe report the first evidence for high-mass star formation triggered by collisions of molecular clouds in M 33. Using the Atacama Large Millimeter/submillimeter Array, we spatially resolved filamentary structures of giant molecular cloud 37 in M 33 using 12CO(J = 2–1), 13CO(J = 2–1), and C18O(J = 2–1) line emission at a spatial resolution of ∼2 pc. There are two individual molecular clouds with a systematic velocity difference of ∼6 km s−1. Three continuum sources representing up to ∼10 high-mass stars with spectral types of B0V–O7.5V are embedded within the densest parts of molecular clouds bright in the C18O(J = 2–1) line emission. The two molecular clouds show a complementary spatial distribution with a spatial displacement of ∼6.2 pc, and show a V-shaped structure in the position–velocity diagram. These observational features traced by CO and its isotopes are consistent with those in high-mass star-forming regions created by cloud–cloud collisions in the Galactic and Magellanic Cloud H ii regions. Our new finding in M 33 indicates that cloud–cloud collision is a promising process for triggering high-mass star formation in the Local Group.
Symplasmic Isolation Contributes to Somatic Embryo Induction and Development in the Tree Fern Cyathea delgadii Sternb
Authors: Grzyb Małgorzata , Wróbel-Marek Justyna , Kurczyńska Ewa , Sobczak Mirosław , Mikuła Anna 
Published: April 2020

AbstractIn this report, we describe studies on symplasmic communication and cellular rearrangement during direct somatic embryogenesis (SE) in the tree fern Cyathea delgadii. We analyzed changes in the symplasmic transport of low-molecular-weight fluorochromes, such as 8-hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt (HPTS) and fluorescein (delivered to cells as fluorescein diacetate, FDA), within stipe explants and somatic embryos originating from single epidermal cells and developing during 16-d long culture. Induction of SE is preceded by a restriction in fluorochrome distribution between certain explant cells. Microscopic analysis showed a series of cellular changes like a decrease in vacuole size, increase in vacuole numbers, and increased density of cytoplasm and deposition of electron-dense material in cell walls that may be related with embryogenic transition. In somatic embryos, the limited symplasmic communication between cells was observed first in linear tri-cellular embryos. Further development of the fern embryo was associated with the formation of symplasmic domains corresponding to the four segments of the plant body. Using symplasmic tracers, we provided evidence that the changes in plasmodesmata permeability are corelated with somatic-to-embryogenic transition and somatic embryo development.
On the rotator Hamiltonian for the SU (N) × SU (N) sigma model in the delta regime
Authors: Balog J , Niedermayer F , Weisz P 
Published: April 2020

Abstract
We investigate some properties of the standard rotator approximation of the $\mathrm{SU}(N)\times\mathrm{SU}(N)$ sigma-model in the delta regime. In particular, we show that the isospin susceptibility calculated in this framework agrees with that computed by chiral perturbation theory up to next-to-next-to-leading order in the limit $\ell=L_t/L\to\infty$. The difference between the results involves terms vanishing like $1/\ell$, plus terms vanishing exponentially with $\ell$. As we have previously shown for the O($n$) model, this deviation can be described by a correction to the rotator spectrum proportional to the square of the quadratic Casimir invariant. Here we confront this expectation with analytic nonperturbative results on the spectrum in two dimensions for $N=3$.
ESTIMATES OF PATIENT DOSES AND KERMA-AREA PRODUCT MONITORING IN DIGITAL RADIOGRAPHY
Authors: Kaushik Chanchal , Sandhu Inderjeet Singh , Srivastava A K 
Published: April 2020

AbstractThe application of the kerma-area product (PKA) meter is increased rapidly in dosimetry. This study presents measurements of PKA in adherence to the International Atomic Energy Agency protocol for 300 adult patients in digital radiographic procedures. Effective doses (ED) were calculated from PKA measurements and conversion coefficients (E-103/PKA) obtained from the International Commission on radiological protection 103. In skull posteroanterior (PA), skull lateral (LAT), cervical spine anteroposterior (AP), cervical spine LAT, chest PA, abdomen AP, lumbar spine AP, pelvis AP and lumbar spine LAT, the third-quartile PKA values were found to be 0.2, 0.28, 0.33, 0.19, 0.26, 0.95, 0.93, 0.96 and 3.15 Gycm2, and estimated mean EDs were 0.005, 0.008, 0.056, 0.021, 0.037, 0.146, 0.165, 0.097 and 0.258 mSv, respectively. The third-quartile PKA values were suggested as local diagnostic reference levels (LDRLs). Results were compared with the diagnostic reference levels (DRLs) of the UK, the European Commission, previously published LDRLs in Greece and China by Metaxas et al. and Zhang and Chu, respectively. The PKA (third-quartile) value for cervical spine AP was 120% higher than UK 2010 DRLs, lumbar spine LAT was 123% higher than LDRLs given by Metaxas et al. and chest PA was 160% higher than UK 2010 DRLs and 225% higher than Metaxas et al. provided LDRLs. The PKA results were lower than the UK, and two studies in Greece by Metaxas et al. except for chest PA, cervical spine AP and lumbar spine LAT showed the need for further optimization. The LDRLs reported in this study may further contribute to establishing future national DRLs.
Precision Surgery for Placenta Previa Complicated with Placenta Percreta
Authors: Chen Juan-Juan , Yu Lin , Su Chun-Hong , Zhang Chun-Fang , Chen Yan-Hong , Zhou Yan-Mei , He Wen-Jun , He Fang , Song Ting , Wang Shou-Ping , Su Zhi-Yuan , Jiang Qing-Ping , Zou Zi-Hao , Yu Bin , Shen Xiao-Ya , Guan Xiao-Ming , Chen Dun-Jin 
Published: April 2020

Abstract

Objectives:
To investigate whether a precise circular resection of the uterine tissue at the placental attachment part is effective in cases with placenta previa complicated with placenta percreta (PPWPP).

Methods:
Patients diagnosed with PPWPP were assessed for pregnancy termination at 34–36 weeks of gestation. During the operation, we performed circular resection of the uterine tissue at the placental attachment part. Then the characteristics of the operation and the follow-ups were recorded.

Results:
During the operation, the vital signs were stable. The mean intraoperative blood loss, packed red blood cells units transfusion, fresh frozen plasma transfusion, and operation time were 2140 mL, 6 U, 440 mL, and 179.8 minutes, respectively. There was no bowel, ureter, or bladder injury. And there was no patient transferred to the ICU after operation. The mean postoperative blood loss was 458.6 mL. There was no fever, infection, intestinal obstruction, or other complications after operation during the hospitalization. The shape and the blood flow of the uterus were normal. After the patients were discharged, one had developed cesarean scar diverticulum. The mean lochia duration was 30 days. The menstrual cycle and volume were as before. The shape and the blood flow of the uterus and the ovarian were normal.

Conclusions:
The circular resection following end-to-end anastomosis is an effective precision surgical approach for PPWPP. It can achieve the purpose of hemostasis while maximizing the protection of organ function and reducing surgical trauma.
Diagnosis of Gestational Diabetes Mellitus in China: Perspective, Progress and Prospects
Authors: Juan Juan , Yang Hui-Xia , Su Ri-Na , Kapur Anil 
Published: April 2020

Abstract
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. Despite extensive research in the past 50 years, the universal approach to diagnose GDM continues to be debated around the world and clinical practices vary from country to country and unit to unit within the same country. As new evidence emerges, the diagnostic criteria of GDM has continuously evolved since the 1990s. In 2011, after the announcement of the landmark International Association of Diabetes and Pregnancy Study Groups diagnostic criteria, many international organizations have accepted and advocated its use. However, there are differences in glucose metabolism among different ethnic groups, and the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study lacked data from mainland China. Whether the criteria developed based on the HAPO study are applicable to China remains to be further validated. In this current review, we will discuss the evolution of GDM diagnostic criteria and guidelines in China, and compare them to that in western countries to figure out the proper recommendations on the diagnosis of GDM among Chinese women.
The Management of Placenta Accrete Spectrum—Burning Questions to Be Solved
Authors: Ma Jing-Mei , Yang Hui-Xia 
Published: April 2020

Abstract
Placenta accreta spectrum disorders resulting in a series of maternal morbidity and mortality has raised attention worldwide including China. There is an urgent need to confront with the dilemma of less evidenced-based recommendation on management, especially the key issues of controversial topics, including accurate prediction, conservative management with adjunct approaches. Chinese academic society along with international exports are on the way to pursue sensible solutions.
Neurodevelopmental Outcome After Fetoscopic Laser Surgery for Twin-twin Transfusion Syndrome: A Systematic Review of Follow-up Studies from the Last Decade
Authors: Knijnenburg Patricia J.C. , Lopriore Enrico , Oepkes Dick , Vreeken Nienke , Tan Ratna N.G.B. , Rijken Monique , van Klink Jeanine M.M. 
Published: April 2020

AbstractObjective:To review the literature on long-term neurodevelopmental outcome after fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS).Methods:A literature search in PubMed, Embase, Emcare, Web of Science, Cochrane library, and Academic Search Premier was performed. Inclusion criteria were studies between 2009 and 2019 in TTTS-survivors treated with fetoscopic laser surgery and followed-up after the neonatal period with cognitive developmental tests and neurologic exams. Exclusion criteria were non-English articles and reviews, case reports, letters, and guidelines.Results:Nineteen articles were included. Long-term severe neurodevelopmental impairment (NDI) was reported by seven and ranged from 4.0% to 18.0% with a mean of 9.7% (95% confidence interval (CI): 7.8–11.5). The prevalence of cerebral palsy ranged from 1.6% to 18.2%, with a mean of 5.1% (95%CI: 4.1–6.2). The mean prevalence of minor impairment was 13.7% (95%CI: 11.4–16.0). However, only 78.9% (15/19) studies used a validated neurodevelopmental test. As studies lack uniform definitions of primary outcome, timing of follow-up, inclusion criteria, and methods, adequate comparison is hampered.Conclusion:The prevalence of severe NDI and cerebral palsy after fetoscopic laser surgery for TTTS in the last decade remains stable around 9.7% and 5.1%, respectively. International agreements on primary outcomes, methods, and follow-up are necessary to improve the knowledge of NDI in TTTS-survivors.