bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertilizer source and placement influence ammonia volatilization losses from water‐seeded rice systems
Authors: Chuong Thort , Plant Richard , Linquist Bruce A. 
Published: April 2020

AbstractAmmonia volatilization, a primary N loss pathway from rice (Oryza sativaL.) production systems, leads to a reduction in N use efficiency and environmental problems. Ammonia volatilization has not been studied in water‐seeded rice systems or where aqueous NH3is the primary fertilizer N source. Our objective was to quantify NH3volatilization from preplant aqueous NH3and compare it with drilled or broadcast urea. In addition, NH3volatilization from a topdress N application applied midseason was quantified. This was accomplished with 10 field experiments representing a range of soil types. Preplant N treatments were a zero‐N control, injected aqueous NH3, broadcast urea, and drilled urea all applied at the farmer application rate to a dry soil. For the topdress experiment, the treatments were a zero‐N control and urea or (NH4)2SO4applied at 34 kg N ha−1. Ammonia volatilization was measured up to 3 and 1 wk after the preplant and topdress N was applied, respectively, using a semi‐open static chamber. Losses due to NH3volatilization from preplant broadcast urea were significantly higher than from the other other treatments but accounted for <2% of applied N. Losses from aqueous NH3and banded urea were lower but were significantly greater than from the control. The losses occurred in the first week after flooding. When N was topdressed, 1.5 and 2.6% of applied N were lost via volatilization from urea and (NH4)2SO4, respectively.
Diet, Lifestyle, Smoking
Authors: Tokgozoglu Lale , Hekimsoy Vedat , Costabile Giuseppina , Calabrese Ilaria , Riccardi Gabriele 
Published: April 2020

AbstractCardiovascular disease is the leading cause of death globally The past few decades have shown that especially low- and middle-income countries have undergone rapid industrialization, urbanization, economic development and market globalization. Although these developments led to many positive changes in health outcomes and increased life expectancies, they all also caused inappropriate dietary patterns, physical inactivity and obesity. Evidence shows that a large proportion of the cardiovascular disease burden can be explained by behavioural factors such as low physical activity, unhealthy diet and smoking. Controlling these risk factors from early ages is important for maintaining cardiovascular health. Even in patients with genetic susceptibility to cardiovascular disease, risk factor modification is beneficial.
Despite the tremendous advances in the medical treatment of cardiovascular risk factors to reduce overall cardiovascular risk, the modern lifestyle which has led to greater sedentary time, lower participation in active transport and time spent in leisure or purposeful physical activity, unhealthy diets and increased exposure to stress, noise and pollution have diminished the beneficial effects of contemporary medical cardiovascular prevention strategies. Therefore attenuating or eliminating these health risk behaviours and risk factors is imperative in the prevention of cardiovascular diseases.
Gender norms about romantic relationships and sexual experiences among very young male adolescents in Korogocho slum in Kenya
Authors: Maina Beatrice W. , Orindi Benedict O. , Sikweyiya Yandisa , Kabiru Caroline W. 
Published: April 2020

Abstract
Objectives
To investigate the association between gender norms about romantic relationships and sexual experiences of very young male adolescents (VYMA) living in Korogocho slum in Nairobi, Kenya.

Methods
We used cross-sectional data from a sample of 426 VYMA living in Korogocho slum. We conducted an exploratory factor analysis and confirmatory factor analysis to, respectively, explore and validate the factor structure underlying gender norms scale items. We used structural equation modelling to assess the association between gender norms and sexual experiences of VYMA.

Results
We found high endorsement of heteronormative beliefs about romantic relationships and low endorsement of sexual double standards. Sexual experience was associated with low endorsement of heteronormative beliefs, being pre-pubertal, school absenteeism and being below recommended grade for age. Sharing a sleeping room with more than two people, been born outside Nairobi, and living in households headed by older persons lowered the likelihood of sexual experience.

Conclusions
Our findings underscore the need for further research to understand how gender norms evolve as young boys transition through adolescence to adulthood and how these changes impact on sexual behaviors
Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides
Authors: Friedrich Sander , Serbian Immo , Hoenke Sophie , Wolfram Ratna Kancana , Csuk René 
Published: April 2020

AbstractThe coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid withmetaorparasubstituted carboxylated malachite green analogs gave conjugates10,11,15, and16that were cytotoxic for several human tumor cell lines. Especially, an oleanolic acid-derived compound10was cytotoxic for MCF-7 human breast carcinoma cells (EC50 = 0.7 μM). These derivatives represent first examples of triterpenoic acid derivatives holding a cationic scaffold derived from malachite green.
Sorafenib administered using a high-dose, pulsatile regimen in patients with advanced solid malignancies: a phase I exposure escalation study
Authors: Mammatas L. H. , Zandvliet A. S. , Rovithi M. , Honeywell R. J. , Swart E. L. , Peters G. J. , Menke-van der Houven van Oordt C. W. , Verheul H. M. W. 
Published: April 2020

Abstract
Background
(Pre)clinical evidence is accumulating that intermittent exposure to increased doses of protein kinase inhibitors may improve their treatment benefit. In this phase I trial, the safety of high-dose, pulsatile sorafenib was studied.

Patients and methods
High-dose sorafenib was administered once weekly in exposure escalation cohorts according to a 3 + 3 design. Drug monitoring was performed in weeks 1–3 and doses were adjusted to achieve a predefined target plasma area under the curve (AUC)(0–12 h). The effect of low gastric pH on improving sorafenib exposure was investigated by intake of the acidic beverage cola.

Results
Seventeen patients with advanced malignancies without standard treatment options were included. Once weekly, high-dose sorafenib exposure was escalated up to a target AUC(0–12 h) of 125–150 mg/L/h, achieving a twofold higher Cmax compared to standard continuous dosing. Dose-limiting toxicity was observed in three patients: grade 3 duodenal perforation (2800 mg sorafenib), grade 5 multiorgan failure (2800 mg sorafenib) and grade 5 biliary tract perforation (3600 mg sorafenib). The mean difference between observed and target AUC(0–12 h) was 45% (SD ± 56%) in week 1 using a fixed starting dose of sorafenib compared to 2% (SD ± 32%) in week 3 as a result of drug monitoring (P = 0.06). Dissolving sorafenib in cola, instead of water, did not improve sorafenib exposure. Clinical benefit with stable disease as the best response was observed in two patients.

Conclusion
Treatment with high-dose, once weekly sorafenib administration resulted in dose-limiting toxicity precluding dose escalation above the exposure cohort of 125–150 mg/L/h. Drug monitoring was a successful strategy to pursue a target exposure.
GM-CSF does not rescue poor-quality embryos: secondary analysis of a randomized controlled trial
Authors: Rodriguez-Wallberg Kenny A. , Munding Bibi , Ziebe Søren , Robertson Sarah A. 
Published: April 2020

Abstract
Purpose
To evaluate implantation potential of cleavage-stage embryos cultured in medium containing 2 ng/ml granulocyte–macrophage colony-stimulating factor (GM-CSF) versus control medium, according to embryo morphological quality and then transferred on day 3.

Methods
Explorative secondary data analysis of a multicenter, randomized, placebo-controlled, double-blinded prospective study of 1149 couples with embryo transfer after IVF/ICSI. This analysis includes a subgroup of 422 subjects with either single-embryo transfer (SET, N = 286) or double-embryo transfer of two embryos with equivalent morphological quality (DET, N = 136). Implantation rate and live birth rate were assessed according to category of morphological embryo quality on day 3.

Results
Culture with GM-CSF did not increase the implantation rate for embryos classified as poor quality. A trend towards greater benefit of GM-CSF on implantation and survival until live birth for top-quality embryos (TQEs) compared with poor-quality embryos was observed, although not statistically significant. For TQEs, the percentage of transferred embryos resulting in a live born baby was: 40.9 ± 5.3% (GM-CSF) versus 30.5 ± 4.6% (control) (P = 0.24; odds ratio [OR] 1.43, 95% confidence interval [CI] 0.79–2.59), and for embryos with less than 6 cells at day 3 this same rate was: 7.4 ± 3.3% (GM-CSF) versus 12.0 ± 4.0% (control) (P = 0.26; OR 0.53, 95% CI 0.17–1.61).

Conclusion
This exploratory analysis is consistent with GM-CSF protecting morphologically normal embryos from culture-induced stress and does not support an effect of GM-CSF in rescuing poor-quality embryos.
ClinicalTrials.gov identifier: NCT00565747.
Varieties of Power
Authors: Mulder Jesse M. 
Published: April 2020

AbstractPower enthusiasts are engaged in two projects: (1) developing a decent metaphysical account of powers, and (2) applying that account in order to make progress on various other philosophical issues, ranging from narrowly related topics such as causality to further removed ones such as free will, reasoning, or perception. I argue that an intermediate step may be taken, one that explores ‘varieties of power’ while still staying within the realm of (1), of ‘pure’ powers metaphysics. Taking this intermediate step provides a much more interesting basis for those involved in project (2), ‘applied’ powers metaphysics. I articulate four such varieties of power by exploring various dimensions in which the explanatory profile of a power can be extended. I then briefly survey how these relate to various further metaphysical issues.
Environmental justice and the SDGs: from synergies to gaps and contradictions
Authors: Menton Mary , Larrea Carlos , Latorre Sara , Martinez-Alier Joan , Peck Mika , Temper Leah , Walter Mariana 
Published: April 2020

AbstractThrough their synergies, trade-offs, and contradictions, the sustainable development goals (SDGs) have the potential to lead to environmental justices and injustices. Yet, environmental justice (EJ), and social justice more broadly, are not currently embedded within the language and spirit of the SDGs. We part from the premise that “many ‘environmental’ problems are, by their very nature, problems of justice” (Lele, Wiley Interdiscip Rev Water 4:e1224, 2017). We review progress in EJ frameworks in recent years, arguing for the need to move beyond a focus on the four principles of mainstream EJ (distribution, procedure, recognition, and capabilities) towards a more intersectional decolonial approach to environmental justice that recognises the indispensability of both humans and non-humans. EJ frameworks, and the SDGs should recognise power dynamics, complex interactions among injustices, and listens to the different ‘senses of justice’ and desires of theorists, activists, and other stakeholder from the Global South. We analyze how EJ frameworks are, or fail to be, incorporated in the SDGs with a focus on the food–water–health nexus (SDG2, 3, 6); climate-energy (SDG7, 13), conservation (SDG14, 15); and poverty and inequality (SDG1, 10). We call attention to the ‘elephant in the room’—the failure to go beyond GDP but instead include economic growth as a goal (SDG8). We argue that sustainable degrowth and intersectional decolonial environmental justices would create better conditions for the transformative changes needed to reach the broader aim of the SDGs: to leave no one behind.
The influence of stirring time and frequency of impeller rotation on evaluation of drops dimensions and rheological properties of the multiple emulsion
Authors: Major-Godlewska Marta 
Published: April 2020

AbstractThe analysis of drops and rheological measurements of the emulsion produced were presented in the article. The influence of stirring time and rotation frequency on the drops size of the emulsion produced in the propeller of diameter D = 0.1 m and liquid height H = 0.5D equipped with four standard flat dividers was defined. The Smith turbine stirrer was used to stir the emulsion produced. The drop size was defined for three different propeller rotation frequencies, 500 rpm, 1000 rpm and 1500 rpm. The stirring time, after which the samples were collected, was accordingly 15 min and 45 min. To produce the emulsion, sunflower oil was used in the oil phase and distilled water in the water phase. There were 6 measurement series all together, and they were presented as the diameter size distribution. The mean arithmetic diameter da, median dm and the mean Sauter diameter d32 were determined. The rheological measurements of the produced emulsions were presented in graphics as a function τ = f(γ) and were described as Herschel–Bulkley and Bingham models presented in Table 3.
Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function
Authors: Vilas-Boas Eloisa Aparecida , Karabacz Noémie , Marsiglio-Librais Gabriela Nunes , Valle Maíra Melo Rezende , Nalbach Lisa , Ampofo Emmanuel , Morgan Bruce , Carpinelli Angelo Rafael , Roma Leticia Prates 
Published: April 2020

Abstract
Background
Free fatty acids (FFAs) are known for their dual effects on insulin secretion and pancreatic β-cell survival. Short-term exposure to FFAs, such as palmitate, increases insulin secretion. On the contrary, long-term exposure to saturated FFAs results in decreased insulin secretion, as well as triggering oxidative stress and endoplasmic reticulum (ER) stress, culminating in cell death. The effects of FFAs can be mediated either via their intracellular oxidation and consequent effects on cellular metabolism or via activation of the membrane receptor GPR40. Both pathways are likely to be activated upon both short- and long-term exposure to FFAs. However, the precise role of GPR40 in β-cell physiology, especially upon chronic exposure to FFAs, remains unclear.

Methods
We used the GPR40 agonist (GW9508) and antagonist (GW1100) to investigate the impact of chronically modulating GPR40 activity on BRIN-BD11 pancreatic β-cells physiology and function.

Results
We observed that chronic activation of GPR40 did not lead to increased apoptosis, and both proliferation and glucose-induced calcium entry were unchanged compared to control conditions. We also observed no increase in H2O2 or superoxide levels and no increase in the ER stress markers p-eIF2α, CHOP and BIP. As expected, palmitate led to increased H2O2 levels, decreased cell viability and proliferation, as well as decreased metabolism and calcium entry. These changes were not counteracted by the co-treatment of palmitate-exposed cells with the GPR40 antagonist GW1100.

Conclusions
Chronic activation of GPR40 using GW9508 does not negatively impact upon BRIN-BD11 pancreatic β-cells physiology and function. The GPR40 antagonist GW1100 does not protect against the deleterious effects of chronic palmitate exposure. We conclude that GPR40 is probably not involved in mediating the toxicity associated with chronic palmitate exposure.
Visibility through invisibility: Spatialized political subjectivities of Alevi youth
Authors: Özata Tolga 
Published: April 2020

AbstractThis article investigates Alevi youth subjectivities in a neighborhood of İstanbul, Okmeydanı, in which mainly Alevi people live, through the youth’s self-positionings in revolutionary groups, which has deeply marked the highly politicized history of the district. The grievances of Okmeydanlı Alevi youth have grown increasingly complex, stemming from experiences of violence, family legacies of victimhood, and, in recent years, new forms of exclusion. Coupled with generational ruptures between youth and their families in experiencing Alevi identity, Alevi youth have created a political identity and collectivity in the sphere of revolutionary politics. In this politicization, Okmeydanı becomes a spatialization of resistance which gives the youth a sense of power to achieve solidarity and find intimacy to defend themselves and their rights. Moreover, for the youth, engaging in a revolutionary political identity enables them to define themselves and redefine Alevi identity in contrast with, and sometimes against, the perceptions of their families. I argue that it is through this performativity that Okmeydanlı Alevi youth achieve self-empowerment and identity construction; and through this performativity in street politics that the youth render their agencies and self-representations visible on public space.
Spontaneous emergence of Josephson junctions in homogeneous rings of single-crystal Sr2RuO4
Authors: Yasui Yuuki , Lahabi Kaveh , Becerra Victor Fernández , Fermin Remko , Anwar Muhammad Shahbaz , Yonezawa Shingo , Terashima Takahito , Milošević Milorad V. , Aarts Jan , Maeno Yoshiteru 
Published: April 2020

AbstractThe chiral p-wave order parameter in Sr2RuO4 would make it a special case amongst the unconventional superconductors. A consequence of this symmetry is the possible existence of superconducting domains of opposite chirality. At the boundary of such domains, the locally suppressed condensate can produce an intrinsic Josephson junction. Here, we provide evidence of such junctions using mesoscopic rings, structured from Sr2RuO4 single crystals. Our order parameter simulations predict such rings to host stable domain walls across their arms. This is verified with transport experiments on loops, with a sharp transition at 1.5 K, which show distinct critical current oscillations with periodicity corresponding to the flux quantum. In contrast, loops with broadened transitions at around 3 K are void of such junctions and show standard Little–Parks oscillations. Our analysis demonstrates the junctions are of intrinsic origin and makes a compelling case for the existence of superconducting domains.
Low birth weight influences the postnatal abundance and characteristics of satellite cell subpopulations in pigs
Authors: Stange K. , Miersch C. , Sponder G. , Röntgen M. 
Published: April 2020

AbstractLow birth weight (LBW) can cause lifelong impairments in muscle development and growth. Satellite cells (SC) and their progeny are crucial contributors to myogenic processes. This study provides new data on LBW in piglets combining insights on energy metabolism, muscle capillarization and differences in SC presence and function. To this aim, muscle tissues as well as isolated myogenic cells of 4-day-old German Landrace piglets were analyzed. For the first time two heterogeneous SC subpopulations, which contribute differently to muscle development, were isolated from LBW pigs by Percoll density gradient centrifugation. The muscles of LBW piglets showed a reduced DNA, RNA, and protein content as well as lower activity of the muscle specific enzymes CK, ICDH, and LDH compared to their normal birth weight siblings. We assume that deficits in energy metabolism and capillarization are associated with reduced bioavailability of SC, possibly leading to early exhaustion of the SC reserve cell pool and the cells’ premature differentiation.
A Randomised Control Trial and Comparative Analysis of Multi-Dimensional Learning Tools in Anatomy
Authors: Wang Chris , Daniel Ben Kei , Asil Mustafa , Khwaounjoo Prashanna , Cakmak Yusuf Ozgur 
Published: April 2020

AbstractThis article presents the results of a study that examined students’ ability to retain what they have learned in an anatomy course after thirty days via using various learning tools for twenty minutes. Fifty-two second-year medical students were randomly assigned to three learning tools: text-only, three-dimension visualisation in a two-dimensional screen (3DM), or mixed reality (MR). An anatomy test lasting for twenty minutes measuring spatial and nominal knowledge was taken immediately after the learning intervention and another thirty days later. Psychometric tests were also used to measure participants’ memory, reasoning and concentration abilities. Additionally, electroencephalogram data was captured to measure the participants’ awakeness during the learning session. Results of this study showed that the MR group performed poorly in the nominal questions compared to the other groups; however, the MR group demonstrated higher retention in both the nominal and spatial type information for at least a month compared to the other groups. Furthermore, participants in the 3DM and MR groups reported increased engagement. The results of this study suggest that three-dimensional visualiser tools are likely to enhance learning in anatomy education. However, the study itself has several limitations; some include limited sample size and various threats to internal validity.
Evaluation of the role of mitochondria in the non-targeted effects of ionizing radiation using cybrid cellular models
Authors: Miranda Silvana , Correia Marcelo , Dias Anabela G. , Pestana Ana , Soares Paula , Nunes Joana , Lima Jorge , Máximo Valdemar , Boaventura Paula 
Published: April 2020

AbstractRadiobiology is moving towards a better understanding of the intercellular signaling that occurs upon radiation and how its effects relate to the dose applied. The mitochondrial role in orchestrating this biological response needs to be further explored. Cybrids (cytoplasmic hybrids) are useful cell models for studying the involvement of mitochondria in cellular processes. In the present study we used cybrid cell lines to investigate the role of mitochondria in the response to radiation exposure. Cybrid cell lines, derived from the osteosarcoma human cell line 143B, harboring, either wild-type mitochondrial DNA (Cy143Bwt), cells with mitochondria with mutated DNA that causes mitochondrial dysfunction (Cy143Bmut), as well as cells without mitochondrial DNA (mtDNA) (143B-Rho0), were irradiated with 0.2 Gy and 2.0 Gy. Evaluation of the non-targeted (or bystander) effects in non-irradiated cells were assessed by using conditioned media from the irradiated cells. DNA double stranded breaks were assessed with the γH2AX assay. Both directly irradiated cells and cells treated with the conditioned media, showed increased DNA damage. The effect of the irradiated cells media was different according to the cell line it derived from: from Cy143Bwt cells irradiated with 0.2 Gy (low dose) and from Cy143Bmut irradiated with 2.0 Gy (high dose) induced highest DNA damage. Notably, media obtained from cells without mtDNA, the143B-Rho0 cell line, produced no effect in DNA damage. These results point to a possible role of mitochondria in the radiation-induced non-targeted effects. Furthermore, it indicates that cybrid models are valuable tools for radiobiological studies.