bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repurposing drugs for treatment of SARS-CoV-2 infection: Computational design insights into mechanisms of action
Authors: Kandwal Shubhangi , Fayne Darren 
Published: August 2020

Abstract
The COVID-19 pandemic has negatively affected human life globally. It has led to economic crises and health emergencies across the world, spreading rapidly among the human population and has caused many deaths. Currently, there are no treatments available for COVID-19 so there is an urgent need to develop therapeutic interventions that could be used against the novel coronavirus infection. In this research, we used computational drug design technologies to repurpose existing drugs as inhibitors of SARS-CoV-2 viral proteins. The Broad Institute’s Drug Repurposing Hub consists of in-development/approved drugs and was computationally screened to identify potential hits which could inhibit protein targets encoded by the SARS-CoV-2 genome. By virtually screening the Broad collection, using rationally designed pharmacophore features, we identified molecules which may be repurposed against viral nucleocapsid and non-structural proteins. The pharmacophore features were generated after careful visualisation of the interactions between co-crystalised ligands and the protein binding site. The ChEMBL database was used to determine the compound’s level of inhibition of SARS-CoV-2 and correlate the predicted viral protein target with whole virus in vitro data. The results from this study may help to accelerate drug development against COVID-19 and the hit compounds should be progressed through further in vitro and in vivo studies on SARS-CoV-2.
Awareness of Oral Cancer Among Dental Patients in Mecca, Saudi Arabia
Authors: Alqahtani Mashael , Nahhas Alla , Malibari Lujain , Alghamdi Maryam , Bazuhier Sara , Abdulrahman Somaya , Aboalshamat Khalid , Salama Rabab 
Published: August 2020

Background:
Oral Cancer (OC) is a serious health problem affecting the oral cavity, which may lead to death. Alcohol, tobacco, and chewing betel are the main risk factors. Early diagnosis and adequate knowledge of OC may improve the survival rate.

Objective:
This study aimed to assess the knowledge about oral cancer among dental patients in Mecca.

Methods:
A cross-sectional study was conducted in the dental clinics of Mecca. Interviewer-administered questionnaires were distributed to 416 respondents aged 18 or older, who spoke Arabic or English, had no history of OC, and participated voluntarily. The questionnaire consisted of three sections. The first regarded demographical data, the second measured knowledge about OC, and the third was concerned with education regarding OC provided by health-care providers. The interviewers also educated the participants by handing brochures with information about OC.

Results:
Knowledge about OC among dental patients in Mecca was found to be significantly low. Only 102 of the 416 participants (24.5%) had any knowledge. Only 3.4% of all participants had been educated about OC by their health-care providers.

Conclusion:
The results of this study show a considerable lack of general knowledge about OC among dental patients in Mecca. Health programs should be developed to raise the community’s awareness.
Conjoint Vehicle License Plate Identification System
Authors: Wiseman Yair 
Published: August 2020

Background:

An autonomous vehicle will go unaccompanied to park itself in a remote parking lot without a driver or a passenger inside. Unlike traditional vehicles, an autonomous vehicle can drop passengers off near any location. Afterward, instead of cruising for a nearby free parking, the vehicle can be automatically parked in a remote parking lot which can be in a rural fringe of the city where inexpensive land is more readily available.

Objective:
The study aimed at avoidance of mistakes in the identification of the vehicle with the help of the automatic identification device.

Methods:
It is proposed to back up license plate identification procedure by making use of three distinct identification techniques: RFID, Bluetooth and OCR with the aim of considerably reducing identification mistakes.

Results:
The RFID is the most reliable identification device but the Bluetooth and the OCR can improve the reliability of RFID.

Conclusion:

A very high level of reliable vehicle identification device is achievable. Parking lots for autonomous vehicles can be very efficient and low-priced. The critical difficulty is to automatically make sure that the autonomous vehicle is correctly identified at the gate.
Intake of iron and inhibitor are not related with anemia on the premarriage women
Authors: Lestari Prasetya , Paratmanitya Yhona , Suliyah Siti 
Published: August 2020

<p><em><strong><br /></strong></em><strong>ABSTRACT</strong></p><p><em><strong>Background</strong>: One of the most frequent nutritional problems in Indonesia occurs is anemia due to iron deficiency. Forty-nine point one percent of women of childbearing age in Indonesia are anemic. Especially on groups of women of childbearing age are usually preparing themselves for married and will become a mother. Factors causing anemia among others insufficient iron intake and high absorption of Fe inhibitors (tannin, phytate, and oxalic acid). If the bride is married to status anemia will affect the birth of a less qualified generation.</em></p><p><em><strong>Objectives:</strong> To know the relationship between iron intake and Fe inhibitor with the incidence of anemia in the bride in the District Area Bantul Yogyakarta. type of research conducted was observational research using a cross sectional design. Number of study subjects as many as 68 respondents in the bride with the picking technique the sample uses quota sampling that meets the inclusion criteria and exclusion. Data collected were data of iron intake and Fe Inhibitors. The data were obtained by interview using SQFFQ. Statistic test used were Mann Whitney and Chi Square test with level of 90% confidence.</em></p><p><em><strong>Results</strong>: The incidence of anemia was 44.1%. Based on the results there was no significant difference between the mean intake of Fe anemia group with anemia not with (p = 0.387). There is no Tanin intake differences were significant between the anemia group and the not anemia with (p = 0.512). There was no difference in intake of Fitat was significant between the anemia group and the non-anemic with (p = 0.335). There was no significant difference in intake of xalates between groups of anemia with no anemia with (p = 0.537). Based on Chi Square Test as well it was known that there is no significant relationship between intake of Fe and Fe inhibitor with anemia incidence (p&gt; 0.05)</em></p><p><em><strong>Conclusions</strong>: There was no significant relationship between intake of Fe and Fe inhibitor with anemia incidence</em></p><p><em><strong>KEYWORDS:</strong> anemia, iron intake, inhibitor Fe, prospective bride</em></p>
Evaluation of a Heart Failure Telemonitoring Program Through a Microsimulation Model: Cost-Utility Analysis
Authors: Boodoo Chris , Zhang Qi , Ross Heather J , Alba Ana Carolina , Laporte Audrey , Seto Emily 
Published: August 2020

Background
Heart failure (HF) is a major public health issue in Canada that is associated with high prevalence, morbidity, and mortality rates and high financial and social burdens. Telemonitoring (TM) has been shown to improve all-cause mortality and hospitalization rates in patients with HF. The Medly program is a TM intervention integrated as standard of care at a large Canadian academic hospital for ambulatory patients with HF that has been found to improve patient outcomes. However, the cost-effectiveness of the Medly program is yet to be determined.

Objective
This study aims to conduct a cost-utility analysis of the Medly program compared with the standard of care for HF in Ontario, Canada, from the perspective of the public health care payer.

Methods
Using a microsimulation model, individual patient data were simulated over a 25-year time horizon to compare the costs and quality-adjusted life years (QALYs) between the Medly program and standard care for patients with HF treated in the ambulatory care setting. Data were sourced from a Medly Program Evaluation study and literature to inform model parameters, such as Medly’s effectiveness in reducing mortality and hospitalizations, health care and intervention costs, and model transition probabilities. Scenario analyses were conducted in relation to HF severity and TM deployment models. One-way deterministic effectiveness analysis and probabilistic sensitivity analysis were performed to explore the impact on the results of uncertainty in model parameters.

Results
The Medly program was associated with an average total cost of Can $102,508 (US $77,626) per patient and total QALYs of 5.51 per patient compared with the average cost of Can $97,497 (US $73,831) and QALYs of 4.95 per patient in the Standard Care Group. This led to an incremental cost of Can $5011 (US $3794) and incremental QALY of 0.566, resulting in an incremental cost-effectiveness ratio of Can $8850 (US $6701)/QALY. Cost-effectiveness improved in relation to patients with advanced HF and with deployment models in which patients used their own equipment. Baseline and alternative scenarios consistently showed probabilities of cost-effectiveness greater than 85% at a willingness-to-pay threshold of Can $50,000 (US $37,718). Although the results showed some sensitivity to assumptions about effectiveness parameters, the intervention was found to remain cost-effective.

Conclusions
The Medly program for patients with HF is cost-effective compared with standard care using commonly reported willingness-to-pay thresholds. This study provides evidence for decision makers on the use of TM for HF, supports the use of a nurse-led model of TM that embeds clinically validated algorithms, and informs the use of economic modeling for future evaluations of early-stage health informatics technology.
TRAÇANDO O PERCURSO DO DESIGN BÁSICO NO IADE
Authors: Neves Ana Glória , Duarte Emília , Dias Diana 
Published: August 2020

Educação em Design, em Portugal; Design Básico; Realidade Virtual
Enquadrado numa investigação que incide no mapeamento do Design Básico no Ensino Superior português, este estudo procura a sua presença e linha evolutiva, num instituto pioneiro do ensino do Design em Portugal, o IADE. Apesar das diferentes expressões e formatos que adquire ao longo de meio século de existência do Instituto, o Design Básico persiste, disponibilizando-se à inovação, nomeadamente, por via do potencial contributo das ferramentas pedagógicas baseadas na Realidade Virtual.
A EMPATIA NO PROCESSO DE DESENVOLVIMENTO DE INTERFACES
Authors: E Souza Manuella Silva , Da Silva Helen Dos Santos , Bitter Ricardo Oliveira , De Medeiros Ivan Luiz 
Published: August 2020

Palavras-chave: Idosos, Tecnologia, Interface.
O presente artigo visa levantar a discussão acerca do design voltado para idosos. A partir da análise do segmento de máquinas de lavar roupas, bem como a compreensão das dificuldades e desafios enfrentados pela terceira idade, projetou-se uma interface voltada para este público, atendendo às especificações que, como visto nas pesquisas, ainda são ignoradas pelo mercado.
Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries
Authors: Teufel Felix , Geldsetzer Pascal , Manne-Goehler Jennifer , Karlsson Omar , Koncz Viola , Deckert Andreas , Theilmann Michaela , Marcus Maja-Emilia , Ebert Cara , Seiglie Jacqueline A. , Agoudavi Kokou , Andall-Brereton Glennis , Gathecha Gladwell , Gurung Mongal S. , Guwatudde David , Houehanou Corine , Hwalla Nahla , Kagaruki Gibson B. , Karki Khem B. , Labadarios Demetre , Martins Joao S. , Msaidie Mohamed , Norov Bolormaa , Sibai Abla M. , Sturua Lela , Tsabedze Lindiwe , Wesseh Chea S. , Davies Justine , Atun Rifat , Vollmer Sebastian , Subramanian S.V. , Bärnighausen Till , Jaacks Lindsay M. , De Neve Jan-Walter 
Published: August 2020

OBJECTIVE
The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent.

RESEARCH DESIGN AND METHODS
We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and diabetes using multilevel mixed-effects logistic regression models. We estimated ORs for the pooled sample, major world regions, and individual countries, in addition to stratifying all analyses by sex. We examined heterogeneity by individual-level characteristics.

RESULTS
Our sample included 554,122 individuals across 25 population-based surveys. Average height was 161.7 cm (95% CI 161.2–162.3), and the crude prevalence of diabetes was 7.5% (95% CI 6.9–8.2). We found no relationship between adult height and diabetes across LMICs globally or in most world regions. When stratifying our sample by country and sex, we found an inverse association between adult height and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model specifications.

CONCLUSIONS
Adult height is not associated with diabetes across LMICs. Environmental factors in early life reflected in attained adult height likely differ from those predisposing individuals for diabetes.
Sodium–Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study
Authors: Yu Oriana Hoi Yun , Dell’Aniello Sophie , Shah Baiju R. , Brunetti Vanessa C. , Daigle Jean-Marc , Fralick Michael , Douros Antonios , Hu Nianping , Alessi-Severini Silvia , Fisher Anat , Bugden Shawn C. , Ronksley Paul E. , Filion Kristian B. , Ernst Pierre , Lix Lisa M. ,   Canadian Network for Observational Drug Effect Studies (CNODES) Investigators, Suissa Samy , Dormuth Colin R. , Hemmelgarn Brenda R. , Quail Jacqueline , Chateau Dan , Paterson J. Michael , LeLorier Jacques , Levy Adrian R. , Ernst Pierre , Filion Kristian B. , Lix Lisa M. , Platt Robert W. , Sketris Ingrid S. 
Published: August 2020

OBJECTIVE
Reports of amputations associated with sodium–glucose cotransporter 2 (SGLT2) inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase 4 (DPP-4) inhibitors among patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
This multicenter observational study used administrative health care databases from seven Canadian provinces and the U.K. Incident SGLT2 inhibitor users were matched to DPP-4 inhibitor users using a prevalent new-user design and time-conditional propensity scores. Cox proportional hazards models were used to estimate site-specific adjusted hazard ratios (HR) and corresponding 95% CIs of incident below-knee amputation for SGLT2 inhibitor versus DPP-4 inhibitor users. Random effects meta-analyses were used to pool the site-specific results.

RESULTS
The study cohort included 207,817 incident SGLT2 inhibitor users matched to 207,817 DPP-4 inhibitor users. During a mean exposed follow-up time of 11 months, the amputation rate was 1.3 per 1,000 person-years among SGLT2 inhibitor users and 1.5 per 1,000 person-years among DPP-4 inhibitor users. The adjusted HR of below-knee amputations associated with SGLT2 inhibitor use compared with DPP-4 inhibitor use was 0.88 (95% CI 0.71–1.09). Similar results were obtained in stratified analyses by specific SGLT2 inhibitor molecule.

CONCLUSIONS
In this large multicenter observational study, there was no association between SGLT2 inhibitor use and incident below-knee amputations among patients with type 2 diabetes compared with DPP-4 inhibitor use. While these findings provide some reassurance, studies with a longer duration of follow-up are needed to assess potential long-term effects.
RANCANG BANGUN SISTEM INFORMASI PERMINTAAN KEBUTUHAN LOGISTIK DI KANTOR WILAYAH II PT PEGADAIAN KOTA PEKANBARU BERBASIS WEB
Authors: Zarnelly Zarnelly , Hidayat Muhammad 
Published: August 2020

Kantor wilayah II PT Pegadaian Kota Pekanbaru mempunyai unit bidang yang melayani permintaan kebutuhan kantor cabang dan unit pelayanan cabang yaitu bidang logistik. Permasalahan yang dihadapi dalam proses permintaan kebutuhan logistik antara lain masih menggunakan pembukuan apabila ada surat permohonan permintaan logistik yang masuk, menyebabkan sulit dalam pencarian data ketika dibutuhkan karena harus mencari data pada pembukuan satu persatu dan pada proses persetujuan harus menunggu pimpinan ketika berada di kantor, apabila pimpinan berada diluar kota proses persetujuan harus tertunda dan menyebabkan penumpukan surat permohonan di kantor sehingga terjadi keluhan dari kantor cabang yang mengajukan permohonan karena permintaan yang diajukan tidak ada pemberitahuan dari bidang logistik. Dengan permasalahan yang terjadi dibutuhkan sistem informasi baru yang terhubung dengan kantor cabang untuk dapat membantu mempermudah pekerjaan para pengguna dalam pengelolaan permintaan kebutuhan di bidang logistik yang menjadi solusi dari permasalahan yang terjadi. Sistem informasi permintaan kebutuhan logistik berbasis web ini menggunakan metode analisa dan perancangan Object Oriented Analysis and Design (OOAD) dan Waterfall pada pengembangan sistem dan tools unified modeling language (UML). Hasil uji Black Box yang dilakukan terhadap fitur yang terdapat pada sistem yang dibuat berjalan 100%. Hasil pengujian menggunakan User Acceptance Test (UAT) yang telah dihitung didapatkan persentase hasil akhir kelayakan sistem yang dibangun sebesar 82.29%.Kata kunci: Black Box, Sistem Informasi Permintaan kebutuhan logistik, User Acceptance Test, Object Oriented Analysis and Design, Waterfall.
حل التناقض بين الاستغلال والاستكشاف (معالجة نظرية)
Authors: Ali Ari M. , Sharafani Dilman Kh. R. 
Published: August 2020

سعت الدراسة الحالية الى محاولة تقصي الاختلاف بين مفهوم الاستكشاف و الاستغلال و سبب التناقض بينهما بالاضافة الى محاولة ايجاد حل لهذا التناقض من خلال طرح مفاهيم فكرية و معالجة نظرية عن طريق بيان المفهمومين و كيفية التوائم بينهما او حتى ربطهما عن طريق البراعة التنظيميةو التي تعتبر محاولة لحل هذا التناقض،و ذلك من اجل الخروج بمنطلقات فكرية و سبل لمعالجة الاشكالات لدى المنظمات من خلال بيان الية معينة تطرحها الدراسة لكيفية الاستفادة من المفهومين و ليس احدهما على حساب الاخر.
وتم التوصل الى عدد من الاستنتاجات اهمها أن التوازن بين الاستغلال والاستكشاف يمثل تحدياً صعباً للغاية في المنظمات التي تعاني النقص في الموارد والقدرات والخبرة اللازمة.
كما و توصلت الدراسة الى مجموعة من التوصيات تمثلت بعدم الاستغراق طويلا في حل التناقض لدى الحكومة و كيفية اختيار احدهما ،انما ايجاد طريقة لحل التناقض و استخدام الامثل او الاثنين معا.
Cuidados de enfermagem para o manejo adequado de náuseas e vômitos em mulheres com câncer de mama em terapia antineoplásica parenteral: revisão integrativa
Authors: Gomes Valéria da Costa , Reginaldo Ana Flávia de Paula Rodrigues , Junior Orácio Carvalho Ribeiro , Campos Genice Lemos , Portugal Jéssica Karoline Alves , Reis Marcelo Henrique da Silva , Junior José Carlos Ferreira Pinheiro , Germano Sibele Naiara Ferreira , Reis Yara da Silva dos , Barbosa Sara Moriá Rodrigues 
Published: August 2020

Objetivo: Identificar na literatura as condutas de enfermagem não farmacológicas frente ao manejo adequado de náuseas e vômitos de acordo com o potencial emetogênico dos protocolos de Terapia Antineoplásica em mulheres com câncer de mama. Métodos: Trata-se de uma revisão Integrativa da Literatura com busca por artigos científicos na Base de Dados em Enfermagem (BDENF), Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS), Sistema Online de Busca e Análise de Literatura Médica (MEDLINE), National Library of Medicine (PUBMED) e Scientific Eletronic Library Online (SCIELO). Resultados: Foram identificados 104 artigos, após o processo de busca e análise, restaram 15, que foram incluídos como amostra final deste estudo. Foi realizado o cálculo do (PE) para definir a classificação dos protocolos em: Alto (> 90 % de chances de náuseas e vômitos durante a TA), Moderado (de 30-90%) e Baixo (de 10-30%). No total, foram contabilizados 48 protocolos estabelecidos para realização da terapia antineoplásica, destes, 29,2% (N=14) Alto, 39,6% (N=19) Moderado, 22,9% (N=11) Baixo e 8,3%(N=4) Mínimo. Considerações finais: O estudo apontou que as principais condutas estão baseadas na implementação de atividades educativas que promovam o conhecimento adequado da paciente em relação ao tratamento e seus possíveis efeitos colaterais.
EFFECT OF FEEDING DIFFERENT INCLUSION RATES OF WATER HYACINTH [EICHHORNIA CRASSIPES (MART.) SOLMS] ON THE BODY WEIGHT GAIN OF GROWING DAIRY BULL CALVES
Authors: Amit Nieta C. 
Published: August 2020

Twenty-four (24) Holstein Friesian-Sahiwal crossbred growing dairy bull calves with average weight of 87.30 kg were used to evaluate the effect of feeding water hyacinth (WH) on the Body Weight Gain (BWG) of growing dairy bull calves at the Dairy Training and Research Institute (DTRI), Dairy Farm, College of Agriculture and Food Science, University of the Philippines (UPLB), College, Laguna from August 2017 to December 2017. WH at 0, 10, 20 and 40% dry matter (DM) basis substitution of Napier grass in the total mixed ration (TMR) served as treatments in six (6) randomized complete blocks, each block consisting of calves at the same weight range. WH at 40% caused increased DM intake in calves but feeding WH to calves did not affect body weight (BW) gain of the calves. Therefore, WH can be used as an alternative feed source at an inclusion rate of 10-20% dry matter basis substitution of Napier grass.
THE TRANSDUCTION OF CELLULAR MEMBRANE PROTEINS AND STRUCTURAL CELL MEMBRANE ALTERATIONS INDUCED BY EXOGENOUS ENERGY WAVES ENERGIZING LIPID DROPLETS AS THE PROPOSED UNDERLYING MECHANISM IN VERY INTENSIVE PRESSURE PULSES TREATMENTS CLAIMS TO A CANCER CURE
Authors: Embi BS Abraham A. , Haltiwanger Steve 
Published: August 2020

The purpose of this manuscript is to propose a mechanism for a cancer cure claim resulting from exogenous stimulation of cancer tumors by very intense pressure pulses (VIPPs) treatments from commercially available energy hardware (CellSonic). Could it be that exogenous continuous pulsating waves alter the cellular lipid bilayer; and this in turn also influence intracellular cell signaling? In Vitro experiments are presented supporting the above-stated thesis. The evidence will show via in vitro experiments how trapping energy from bursting oxygen bubbles induces static electricity discharges up to causing luminescence of intracellular lipid droplets. Figures and video recordings documenting the above-mentioned phenomena are presented. In summary, proposed is a mechanism explaining a cancer cure claim via VIPPs.
1 AAE: Idealized, designed wrote manuscript and conducted in vitro experiments possibly demonstrating a mechanism for VIPPs cancer cure.
2 SH: Added theoretical principles in the discussion supporting the proposed VIPPs mechanism to cancer cure.