bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTIOXIDATIVE AND FREE RADICAL SCAVENGING POTENTIALS OF CYCLOSORUS INTERRUPTUS (WILLD.) H. ITÔ AND PRONEPHRIUM NUDATUM (ROXB. EX GRIFF.) HOLTTUM
Authors: ABHIJIT MITRA  , MANABENDRA DUTTA CHOUDHURY  , PRAKASH ROY CHOUDHURY  , DEEPA NATH  , SUBRATA DAS  , ANUPAM DAS TALUKDAR  
Published: January 2020

Objectives: The work aims to screen the antioxidative potentials of different crude extracts of the fronds of two medicinally important pteridophytes of Southern Assam, India, namely, Cyclosorus interruptus (Willd.) H. Itô and Pronephrium nudatum (Roxb. ex Griff.) Holttum.
Methods: Frond extracts of the pteridophytes were prepared by Soxhlet hot extraction method. Total phenolic content (TPC) and total flavonoid content (TFC) of the hexane, ethyl acetate, acetone, and methanol extracts of the fronds of the plants were done by following standard protocol. In vitro assessment of the antioxidative behavior of the extracts was performed using standard 2,2-diphenyl-1-picrylhydrazyl scavenging assay, reducing power assay, metal chelating assay, hydroxyl, superoxide, and 2,2’- azino-bis (3-ethylbenzothiazoline - 6 – sulfonic acid) radical scavenging methods in different in vitro systems.
Results: Preliminary phytochemical analysis implicated the presence of phenolic and flavonoid compounds in all the frond extracts. The methanol extract of the fronds of both the plants showed maximum phenolic and flavonoid contents in comparison to the other extracts, however, that of C. interruptus was found to be higher than P. nudatum. Antioxidative potentials of the said extracts were also found to be impressive and noteworthy. The decreasing order of the antioxidative efficacies of the extracts was found to be same as that of TPC and TFC of the extracts.
Conclusion: It is pertinent to comment that the methanol extract of the fronds of both the plants may be treated as a potential source of natural antioxidants.
EFFECT OF JAPAN WATER THERAPY INFUSED WITH CINNAMON ON BODY WEIGHT, WAIST/HIP RATIO, AND BODY MASS INDEX OF OVERWEIGHT AND OBESE SUBJECTS
Authors: SHIVANI BHATIA  , SHUBHRA SARASWAT  
Published: January 2020

Objective: The objective of this study was to discover the effect of Japan water therapy with cinnamon on body composition in overweight and obese subjects.
Methods: The study was conducted with 36 subjects divided into three groups, namely, Group A – water therapy with cinnamon (n=12), Group B – water therapy (n=12), and Group C – warm water (n=12), where Groups A and B were test groups and Group C was a control group. This study was carried out for 8 weeks. Body weight, waist/hip ratio (WHR), and body mass index (BMI) were measured every 15th day. Data were statistically analyzed by mean, standard deviation, and paired t-test using Getcalc.com
Results: Out of all the groups, Group A showed desirable reduction in weight, WHR, and BMI, but statistically it was non-significant on WHR. Similarly, Group B had non-significant result with content to WHR but showed a moderate reduction in all categories. However, Group C as a control group both had either constant or minimal reduction in WHR and BMI being statistically non-significant.
Conclusion: The findings of the study concluded that consumption of Japan water therapy with cinnamon helps in reduction of weight, WHR, and BMI within 8 weeks. Plain water therapy only had a moderate effect on reducing body composition in the same duration of time.
COLOR INTENSITY AND ANTIOXIDATIVE CAPACITY OF FOUR NATURAL MONOFLORAL HONEY FROM MALDA, INDIA
Authors: SURAJIT ROY  , SHYAMAPADA MANDAL  
Published: January 2020

Objective: The objective of the study was to explore the color intensity and antioxidative capacity of mango honey available from local niches, in and around Malda, West Bengal, India.
Methods: Four mango honey samples: LMH1, LMH2, LMH3, and LMH4, were collected from bee hives, in and around Malda, India, and were subjected to determine the color intensity and antioxidative capacity in 2, 2-diphenyl-1-picrylhydrazyl system.
Results: The honey samples tested had light to dark color variation with color intensity values of 583.59–1842.84 mAU. The total phenolic content (TPC) of the honey samples ranged from 434.52 to 1450.74 μg gallic acid equivalents/ml, while the total flavonoids content (TFC) ranged 39.4–72.67 mg quercetin equivalents/100 g of honey. The honey samples displayed antioxidative activity (AOA) with 9.91–76% inhibition capacity, and the IC50 values of 8.37–19.38 mg/ml. The color intensity of test honeys displayed positive correlation with the TPC (r=0.907) and TFC (r=0.863), while negative correlation between honey color intensity and IC50 values (r=−0.955) was recorded.
Conclusion: The locally available mango honeys were rich in bioactive components displaying excellent AOA, and thus, the native honey might be utilized as the potential source of natural antioxidant in our part of the globe.
THE BENEFIT EFFECT OF GINGER SUPPLEMENTATION AGAINST NICKEL-INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS
Authors: SARA DERBAL  , ZINE KECHRID  
Published: January 2020

Objective: This study was performed to study the potential capacity effect of ginger on the modulation effects of nickel-induced hepatotoxicity.
Methods: Thirty-two female albino Wistar rats were divided into four groups of eight each. One served as a control group, the second group (Gi) received ginger 20 g/kg diet, while the third group (Ni) was given nickel 800 mg/L in their drinking water as NiSO46H2O and the fourth group (Ni+Gi) was treated daily with both nickel and ginger. The experiment was lasted for 21 days.
Results: The exposure to nickel led to a significant decrease in body weight and food intake with an increase of liver weight. Nickel treatment also produced oxidative liver injury characterized by an increase of glucose, cholesterol, triglyceride, total lipids, bilirubin, malondialdehyde (MDA) concentrations and glutamate-pyruvate transaminase, glutamic oxaloacetic transaminase, and alkaline phosphatase activities. Meanwhile, serum total proteins and liver reduced glutathione (GSH) levels, catalase, GSH peroxidase, and GSH superoxide dismutase activities were decreased. These results are substantiated with marked changes in the histopathology, whereas the supplementation of ginger resulted in a restoration of the previous parameters.
Conclusion: It seems that ginger supplementation is a potent factor for reducing the oxidative severity of nickel hepatotoxicity through its antioxidant action.
IN SILICO ANALYSIS OF ACTIVE CONSTITUENTS OF SILYMARIN AS ΑLPHA-GLUCOSIDASE ENZYME INHIBITORS IN TYPE 2 DIABETES MELLITUS
Authors: AHMAD ZONOUBI  , PRASHANTHA CN  , D VISAGA PERUMAL  , ZAHRA MAFIBANIASADI  
Published: January 2020

Objective: Type 2 diabetes mellitus (T2DM) is an acute metabolic disorder, in which the vogue is increasing persistently globally. The maltase-glucoamylase/alpha-glucosidase inhibitor is an oral antidiabetic drug collectively, which is utilizing for regulating carbohydrates that ordinarily transformed into simple sugars and absorbed by the intestine. Researchers need to constantly explore alternative therapeutic strategies for the clinical management of DM due to the increased adverse event caused by conservative antidiabetic agents. The present study proposes a substitute drug to examine the seven bioactive phytocomponents of Silybum marianum (milk thistle) that can regulate the hyperglycemia by downregulating alpha-glucosidase and its activity.
Methods: Different integrated web-based in silico tools and techniques were used to model the enzyme (receptor) as well as to determine the druggability of different active constituents of silymarin and their pharmacokinetics were predicted. Further, the active site of the enzyme was predicted followed by molecular docking method.
Results: The results show silychristin A and silydianin having less carcinogenicity and strong interaction to the target protein (alpha-glucosidase) compare to the reference drugs (acarbose and miglitol) and these two molecules can be used for the best drug molecules in T2DM.
Conclusion: In the proposed study, the in silico analysis helps researchers to utilize these compounds for clinical applications. The conclusion also suggests that synthetically and semi-synthetically, nucleus and peripheral modifications, either in the form of skeletal rearrangements or partial degradations as well as functional group addition and replacement of the active molecules present in silymarin giving access to new structural motifs, which can be used in future as a lead compounds for antagonising the alpha-glucosidase in the treatment of diabetes mellitus.
METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF CLOTRIMAZOLE, MICONAZOLE NITRATE, AND TINIDAZOLE BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD IN TABLETS
Authors: DEEPIKA SHARMA  , KOMAL GUPTA  , POOJA CHAWLA  
Published: January 2020

Objective: The aim of the study is to develop and validate a high-performance liquid chromatographic method for the simultaneous determination of clotrimazole, miconazole nitrate, and tinidazole tablet dosage forms.
Materials and Methods: A Waters C18 column (50 mm×4.6 mm, 5 μm) with mobile phase consisting of acetonitrile, methanol, and water 55:25:20 (v/v) (pH 2.5 adjusting with 0.5% orthophosphoric acid) was used. The flow rate was 1.0 ml/min, and effluents were monitored at 210 nm.
Results: The retention time of miconazole nitrate, tinidazole, and clotrimazole tablets was found to be 2.9 min, 3.5 min, and 4.7 min, respectively. The method was validated according to the ICH guidelines for specificity, limit of detection, limit of quantification, precision, accuracy, linearity, ruggedness, and robustness.
Conclusion: The method shows good reproducibility and recovery with % relative standard deviation <2. Hence, the proposed method was found to be simple, specific, precise, accurate, and linear. Hence, it can be applied for routine analysis of clotrimazole, miconazole nitrate, and tinidazole in pharmaceutical combined dosage forms.
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF AMPRENAVIR IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY–ELECTROSPRAY IONIZATION–TANDEM MASS SPECTROMETRY
Authors: SUSMITHA K  , MENAKA M  
Published: January 2020

Objective: The main aim of the present study was to develop a sensitive liquid chromatography–electrospray ionization–tandem mass spectrometric technique for the quantitation of amprenavir in human plasma.
Methods: Chromatographic separation was achieved on a reversed-phase Symmetry C18 (50 mm×4.6 mm, 3.5 μm) column with isocratic elution by acetonitrile and 0.1% v/v formic acid in the ratio of 90:10 v/v as mobile phase. Chromatographic peaks were resolved with 0.7 ml/min flow rate. Drug was extracted with ethyl acetate solvent by liquid–liquid extraction method. Monitoring of transition of m/z 506.2 and 71.0 for amprenavir and 628 and 421 for methyl-indinavir was made on multiple reaction monitoring.
Results: Calibration curve of amprenavir was linear over 1–600 ng/ml concentration range with regression coefficient (r2) value of >0.99. The % relative standard deviation values were <8.5% for interday and intraday precision and accuracy. The method has excellent recovery, and the percentage recovery values of lower quality control (QC), median QC, and higher QC samples were 101.86%, 102.8%, and 99.28%, respectively.
Conclusion: The drug was stable for more time at variable stability conditions, and method was successfully applicable to regular analysis of amprenavir in biological matrices.
FORMULATION OPTIMIZATION AND EVALUATION OF MOUTH DISSOLVING FILM OF APREPITANT
Authors: ADITI D BAVISKAR  , BARI MM  , BARHATE SD  
Published: January 2020

Objectives: The aim of the present research is to prepare mouth dissolving film of aprepitant used in the prevention and treatment of post-operative nausea and vomiting.
Methods: The MDF was prepared using Kollicoat IR, PEG 400, and spraying technique. Formulation was optimized by central composite design. Compatibility study was carried out using Fourier-transform infrared and differential scanning calorimetry. The films were evaluated for thickness, folding endurance, weight variation, disintegration time, dissolution studies, drug content, and in vitro diffusion test.
Results: From the results, it was found that there was no drug excipient interaction. The prepared optimized batch AP2 showed disintegration time 18 sec, highest dissolution rate 101.53%, drug diffused 39.58 mg/cm2 within 10 min and also passes all the physicochemical parameters. It was concluded that plasticizer PEG 400 plays a very much important role in the preparation of aprepitant MDF.
Conclusion: MDF of aprepitant was found to be a better option in the prevention and treatment of post-operative nausea and vomiting by the way of fast onset of action for patient convenience and compliance. In the near future, the MDF market will expand very fastly to treat various diseases.
IDENTIFICATION OF BIOACTIVE COMPOUNDS IN FLOWER OF TABERNAEMONTANA DIVARICATA (L.) USING GAS CHROMATOGRAPHY–MASS SPECTROMETRY ANALYSIS
Authors: KALAIMAGAL C  
Published: January 2020

Objective: Herbs are a key resource with therapeutic properties. Nowadays, there is a focus on the identification of bioactive compounds with the ability to act against various disorders.
Methods: In the present study, gas chromatography–mass spectrometry analysis was conducted to determine the occurrence of different phytochemical compounds in ethanolic flower extract of Tabernaemontana divaricata (L.).
Results: The ethanol extract of flower revealed the presence of several bioactive compounds such as n-hexadecanoic acid, squalene, Vitamin D3, Vitamin A aldehyde, desulfosinigrin, and Urs-12-en-24-oic acid, 3-oxo-, methyl ester, (+)-.
Conclusion: The perceived compounds from ethanolic extract of flower have diverse beneficial properties such as antimicrobial, antioxidant, cancer anticipatory effect, pesticide, and antiarthritic.
AN AN STUDY OF ANALGESIC ACTIVITY OF HAFFNER’S TAIL CLIP METHOD ON ALBINO WISTAR RATS OF SOME POLYHERBAL FORMULATION
Authors: LOKENDRA SINGH  
Published: January 2020

Objective: Herbal drugs are more beneficial better than aspirin because this is an herb so no side effect this drug and it is easy to collect or use to as herbal drugs. Words are inadequate to describe the motivation for my work given to my beloved guide. I would like to add special thanks to my guide Gauravbilwal, for their guidance, support, and encouragement.
Purpose (Hypothesis): The main purpose of this article pays to attention for herbal drugs because they are naturally old effective drugs. As well as, Ayurveda treatment is very older effective technique.
Design/Method: Haffner gave to this technique of determining analgesic are around in 1929.
Procedure: This technique according to tail if clipped with any object and tightly or will be compression generation of pain in the tail as well as mice starting to bite that portion of its tail, and could evaluate and recorded the response how much it bites tail quickly or in potential.

Using this simple yet important marvel, we may apply the drug to be evaluated and record the response whether it bites tail quickly or in potential.
If given drugs have analgesic likely, then rat will not bite its tail so frequently.
Mice that do not show any response within 15 s will reject from the experiment.

Results: The found in analgesic activity of additional compounds test to significant on tail flick test than acetic acid-induced test and thus it appears that the test compounds inhibit predominantly the peripheral pain mechanism. The results of the study indicate that the extracts of polyherbal plants of analgesic activity by reducing the abdominal constriction significantly and may supposed to have a possible role in inhibition of cyclooxygenase in the prostaglandin pathways (p****<0.0001, ***0.0001, *0.05).
Conclusion: The present study showed the significant analgesic effect of both aqueous and alcoholic at 400 mg/kg doses in albino rats, we reported for the 1st time analgesic effect of different plants (Curcuma longa, Colchicaceae, Colocynthis, Withania somnifera, and Achyranthes aspera) in Haffner’s tail clip models. Aspirin has each uncoated effervescent tablet content are acetylsalicylic acid I.P. 325 mg. Finally summarized in this article represent a most effective results of herbal drugs equalized allopathic drugs without any other side effect. Hence, this is very usefully combination of Ayurveda drugs.
MOLECULAR DOCKING OF ANTITRYPANOSOMAL INHIBITORS FROM EUCALYPTUS TERETICORNIS FOR SLEEPING SICKNESS
Authors: AARTHI RASHMI B  , HARISHCHANDER A  , PRIYANKA K  , VASANTH NIRMAL BOSCO  
Published: January 2020

Objectives: This study aims to investigate the antitrypanosomal inhibitors of Eucalyptus tereticornis for sleeping sickness through molecular docking and studies on Absorption distribution metabolism excursion and toxicology (ADMET).
Methods: In silico molecular docking in ArgusLab software and ADMET analysis in AdmetSAR software was performed for the antitrypanosomal inhibitors of E. tereticornis for sleeping sickness.
Results: Interactions were studied for the ten proteins responsible for sleeping sickness with the 50 antitrypanosomal inhibitors of E. tereticornis. Docking was performed to see the interaction and the best binding energy of compounds with the proteins involved in sleeping sickness. The docking scores were highest for betulonic acid with −15.66 kcal/mol followed by euglobal with −12.24 kcal/mol, B-pinene with −10.313 kcal/mol, A-pinene with −10.3418 kcal/mol, and the least docking score for P-cymene with −10.6045 kcal/mol. Docking results showed that only betulonic acid and euglobal showed that hydrogen bond interaction was as b-pinene, a-pinene, and p-cymene yielded no hydrogen bond interactions so we will be taking the former docking results for further studies. The best docking result was shown by betulonic acid with trypanothione reductase giving binding energy of −15.66 kcal/mol with hydrogen bond interaction of 2.9, so this result was taken for further analysis.
Conclusion: The results of the compound extracted from E. tereticornis will become physiological relevant only when (i) the pure compounds of this plant is available in large quantities; (ii) the Eucalyptus is biochemically stabilized to avoid degradation and enhance absorption in the gastrointestinal tract; and (iii) special delivery methods for this drug to reach the areas of treatment. In this work, the efficacy of E. tereticornis to act against trypanosomal protein was initiated and thus further research in this process would help us to take full advantage of the remedial effects of the compounds extracted from this plant.
¿Una nueva constitución política mexicana?
Authors: Verdín Pérez Jaime Arturo 
Published: January 2020

Con base en el nuevo parámetro interpretativo resultante de las transformaciones políticas en nuesto país, que sirven como referencia al hablar de una posición privilegiada de la Constitución Política como ordenamiento jurídico con un alto contenido progresivo de derechos y libertades fundamentales a partir de la enmienda constitucional de 2011, en materia de derechos humanos y sobre la que existe un influjo considerable de normas provenientes de un sistema internacional que permiten una amplia protección para los derechos y libertades de las personas, nos obliga a cuestionarnos si es necesario que exista ¿una nueva Constitución Política?
Además de ello, resulta indispensable cuestionar la vigencia, oportunidad, eficacia y fuerza normativa de la Constitución vigente a partir de 1917, considerando que la Constitución tiene normas de organización, de garantías y de procedimiento que obliga a hacer primar su obediencia, permitiendo con ello, el respeto de los derechos fundamentales y su capacidad de adaptación al cambio social.
V International Symposium “Mobility and Migration: Concepts, Methods, Results” (Novosibirsk, August 19–24, 2019)
Authors: Polos'mak Natal'ya , Hansen Svend , Molodin Vyacheslav , Myl'nikova Lyudmila 
Published: January 2020

The paper presents the results of the V International Symposium “Mobility and Migration: Concepts, Methods, Results” organized by the Institute of Archaeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences (Novosibirsk) and the German Archaeologi­cal Institute, its Eurasian Branch (Berlin). The event took place in August 2019 at the R&D centre of Denisova Cave Institute of Archaeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences (Altai). The forum brought together the masterminds from the leading scientific institutions of Russia, Austria, Hungary, Germany, Norway, Poland.
The reports presented the comp temporary research on mobility and migration. Study me­thods are outlined, models are proposed.
Doces da Resistência: A Luta pela Manutenção das Práticas Tradicionais de Produção de Doces Coloniais de Pelotas (RS)
Authors: Krone Evander 
Published: January 2020

RESUMOEste trabalho procura lançar luz sobre as formas de resistência desenvolvidas por famílias rurais para garantir a manutenção das suas receitas e práticas tradicionais de produzir e de viver, em um contexto marcado pelas proibições colocadas pelos órgãos de vigilância sanitária do Estado sobre os seus modos de produzir. O trabalho toma como universo empírico de observação famílias rurais produtoras de receitas tradicionais de doces de frutas do município de Pelotas (RS). A pesquisa, realizada entre os anos de 2014 e 2018, demonstra que os sujeitos estudados buscaram desenvolver ações desviacionistas de modo a burlar o poder disciplinar do Estado, evidenciando a existência de processos de luta e resistência cultural às mudanças impostas nos modos tradicionais de produzir das famílias rurais. A abordagem metodológica da pesquisa seguiu a tradição do método etnográfico, com a realização de 15 entrevistas semiestruturadas com famílias rurais da região, aliado ao procedimento de observação participante e a realização de registros imagéticos.Palavras-chave: Resistência. Campesinato. Produtos Tradicionais. Alimentação. ABSTRACTThis paper seeks to shed light on the forms of resistance developed by rural families to guarantee the maintenance of their traditional recipes and practices of producing and living in a context marked by the prohibitions placed by the State’s health surveillance organs. The work takes as empirical universe producers of traditional recipes of fruit sweets from the municipality of Pelotas (RS). The research, conducted between 2014 and 2018, shows that the subjects studied sought to develop deviant actions to circumvent the State's disciplinary power, evidencing the existence of processes of struggle and cultural resistance to the changes imposed on the traditional ways of producing. The methodological approach followed the ethnographic method tradition, with the accomplishment of 15 semi-structured interviews with rural families of the region, besides the use of the participant observation procedure and the realization of imagery records. Keywords: Resistance. Peasantry. Traditional Products. Food.