bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression and associated factors among parents of children diagnosed with cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
Authors: Mekonnen Helina , Gebreyohannis Gebretensaye Tigistu , Cherie Amsale 
Published: April 2020

AbstractBackgroundThe global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. The period of child's diagnosis negatively influences parents socially and psychologically leading to depression.ObjectivesThe aim of the study was to assess the prevalence of depression, its associated factors and parent's experience towards care of their cancer diagnosed child.MethodsA mixed approach quantitative and qualitative cross‐sectional study was employed between 15 March and 1 April 2017. Systematic random sampling involving 275 participants in the quantitative and 20 conveniently selected participants for qualitative study were included in the study. Beck's depression inventory scale was used to collect data. Logistic regression including bivariate and multivariate analysis considering 95% confidence interval (CI) was utilized to examine association between dependent and independent variables. P‐value <.05 was considered statistically significant. Thematic analysis was used to analyze qualitative data.ResultsThe prevalence of depression among parents was 72.4%, with depression levels of: borderline 7.3%, moderate 6.2%, severe 6.5%, and extreme severe depression 3.3%. Single parenting, income, history of depression, and support source were associated with parental depression (adjusted odds ratio, AOR = 6.21; 95% CI: 2.66‐14.52), (AOR = 0.34; 95% CI: 0.02‐0.86), (AOR = 8; 95% CI: 1.7‐37.4), (AOR = 38; 95% CI: 2.6‐560), respectively.ConclusionFamily income, single parenting, and support sources are determinant factors for parental depression in this study. Nurses should early detect parents at risk and give due attention to reduce the risk of depression.
Being a mother after a cancer diagnosis during pregnancy: Maternal psychosocial functioning and child cognitive development and behavior
Authors: Betchen Melanie , Grunberg Victoria A. , Gringlas Marcy , Cardonick Elyce 
Published: April 2020

AbstractObjectiveUp to 51.5% of women diagnosed with cancer during pregnancy experience trauma (eg, intrusive thoughts, avoidance) and 20% report anxiety. Maternal anxiety can negatively affect child behavior among the noncancer population. This study aims to elucidate relationships between maternal distress, parenting style, and child behavior and development among women with cancer during pregnancy.MethodsThis cross‐sectional study of child cognitive, language and motor development analyze child behavior in the context of maternal psychosocial well‐being after a cancer diagnosis during pregnancy. A subset of women (N = 69) enrolled in the Cancer and Pregnancy Registry, had children undergo developmental testing. The majority underwent Bayley Scales III (children 6‐42 months of age; 0‐3.5 years) to assess language, cognitive, and motor performance. Women completed the Basic Symptom Inventory, Impact of Events Scale, Parent Behavior Checklist, and Child Behavioral Checklist. Maternal and child assessments were performed concurrently.ResultsSixty‐nine women and 71 children (2 sets of twins) ages 6 months to 12 years participated. Maternal depressive and somatic symptoms were associated with more externalizing behaviors. Among younger children (0‐3.5 years), maternal somatic symptoms were associated with poorer language performance. Moderation analysis showed that mothers with fewer somatic symptoms and utilization of less discipline had children with less externalizing behaviors and higher language scores (ie, stronger verbal ability).ConclusionsGiven the interplay of psychosocial factors on child behavior and development, findings highlight the importance of early screening and psychosocial intervention and support for mothers diagnosed with cancer in pregnancy.
Sexual health in colon cancer patients: A systematic review
Authors: Stulz Alexandra , Lamore Kristopher , Montalescot Lucile , Favez Nicolas , Flahault Cécile 
Published: April 2020

AbstractObjectiveDespite the impact that diagnosis and treatment can have on patients' sexual health, very little research has been conducted on the impact of colon cancer on sexual health. The aim of this systematic review was to assess the prevalence of sexual dysfunctions in colon cancer and describe the sociodemographic, clinical, and psychological correlates of sexual dysfunction.MethodsFour electronic databases (PsycINFO, PubMed, AcademicSearchPremier, Cochrane Library) were searched for studies reporting sexual adjustment outcomes for colorectal cancer patients from January 1990 to July 2019.ResultsOf the 380 articles screened, 14 were included in this review. Sexual function is affected by colon cancer: patients' sexual satisfaction decreases significantly, as does the frequency of sexual intercourse. There is an increase in sexual problems (desire, excitement, or pleasure disorders). Male gender, advanced age, distress, and the comorbidities increase sexual disorders. In addition, it appears that partner distress negatively affects patients' sexual health. Taking such difficulties into account appears key for these patients and their partners. They could benefit from better care throughout treatment and in remission.ConclusionThe results of this systematic review highlight the importance of taking an interest in the sexual health of patients with colon cancer.
Agreement and reliability of a symptom modification test cluster for patients with subacromial pain syndrome
Authors: Riley Sean P. , Grimes Jason K. , Apeldoorn Adri T. , de Vet Riekie 
Published: April 2020

AbstractObjectivesTo identify if a plausible theoretical construct exists for a test cluster in a group of patients with subacromial pain syndrome presenting with glenohumeral internal rotation deficit (GIRD); determine the intertester agreement and reliability of the proposed test cluster; determine if there are any meaningful relationships between the test cluster and the component tests for the entire sample; and determine if there are any differences in disability on the Dutch version of the shoulder pain and disability index between participants with a positive and negative test cluster.MethodsThis study is a retrospective secondary analysis of data that were collected to determine the interrater agreement and reliability of clinical tests for assessment of patients with shoulder pain in primary care.ResultsThe test cluster total agreement and negative specific agreement was 87.8 and 90.4%, respectively. The prevalence‐adjusted bias‐adjusted kappa for the test cluster was substantial at 0.76. There were statistically significant meaningful relationships (≥0.50) between GIRD and the test cluster for Tester A (Phi = 0.71, p < .01) and Tester B (Phi = 0.82, p < .01). No differences in disability were identified between those with a positive and negative test cluster.ConclusionThe test cluster described in this study may be a reliable means of identifying a subgroup of patients with subacromial pain syndrome related to GIRD. Future research should look to validate this test cluster prospectively.
A time‐dependent density functional study on optical response in all‐inorganic lead‐halide perovskite nanostructures
Authors: Zhang Bofeng , Zhang Hong , Lin Jiahe , Cheng Xinlu 
Published: April 2020

AbstractRecently, all‐inorganic perovskite nanostructures have become a hot research topic due to their unique optical response and novel properties. Here, we theoretically study the optical response in Cs2PbX4 and CsPb2X5 (X = Cl, Br, and I) nanostructures. First, to study the ground state, we calculate the band structures of the periodic system using the HSE06 method, which shows that all those periodic perovskites possess the direct band gaps, with distribution from 2.225 to 3.536 eV. Their valence band maximum are mainly contributed from both halogen and lead atoms, while the conduction band minimum are mainly contributed from lead atoms. Then, we study the excited state using the time‐dependent density functional theory method and find that, with the increase of halogen atom radius, the photogenerated carrier concentrations in perovskite nanostructures become larger, while the surface plasmon resonance becomes localized rather than long‐range. Moreover, through the analysis of photocurrent and local field enhancement, Cs2PbX4 and CsPb2X5 nanostructures exhibit nearly 40 μA photocurrent along the direction of optical polarization. Besides, by regulating the different anions, we predict that field enhancement in Cs2PbI4 and CsPb2I5 share a much stronger distribution at both the center and border parts of Pb‐I planes due to localized plasmon resonance, while other perovskites are distributed at the edge parts of Pb‐I planes, caused by long‐range plasmon resonance. Our research shows that all‐inorganic perovskite nanostructures are great candidate materials for developing optoelectronic devices working in high‐frequency and high‐energy regions and improving their application in sensitive detection and sensors.
Two cancer stem cell-targeted therapies in clinical trials as viewed from the standpoint of the cancer stem cell model
Authors: Caras Ingrid W. 
Published: April 2020

Abstract
A key implication of the cancer stem cell model is that for a cancer therapy to be curative, it is imperative to eliminate the cancer stem cells (CSCs) that drive tumor progression. The California Institute for Regenerative Medicine is supporting two novel approaches that target CSCs, one an antibody-mediated immunotherapy targeting CD47 and the other an antibody targeting ROR1. This article summarizes the evidence that CSCs are targeted and discusses the results of early clinical trials within the context of the CSC model.

Significance statement The premise and predictions of the cancer stem cell model of cancer are being tested in the clinic as cancer stem cell-targeted therapies enter clinical trials. This article describes two such approaches and discusses whether the initial clinical results are consistent with predictions of the model. Validation of the cancer stem cell model in humans has implications for the design of curative treatments for many human cancers.
Autonomic resource provisioning for multilayer cloud applications with K‐nearest neighbor resource scaling and priority‐based resource allocation
Authors: Mazidi Arash , Golsorkhtabaramiri Mehdi , Tabari Meisam Yadollahzadeh 
Published: April 2020

SummaryProviding a pool of various resources and services to customers on the Internet in exchanging money has made cloud computing as one of the most popular technologies. Management of the provided resources and services at the lowest cost and maximum profit is a crucial issue for cloud providers. Thus, cloud providers proceed to auto‐scale the computing resources according to the users' requests in order to minimize the operational costs. Therefore, the required time and costs to scale‐up and down computing resources are considered as one of the major limits of scaling which has made this issue an important challenge in cloud computing. In this paper, a new approach is proposed based on MAPE‐K loop to auto‐scale the resources for multilayered cloud applications. K‐nearest neighbor (K‐NN) algorithm is used to analyze and label virtual machines and statistical methods are used to make scaling decision. In addition, a resource allocation algorithm is proposed to allocate requests on the resources. Results of the simulation revealed that the proposed approach results in operational costs reduction, as well as improving the resource utilization, response time, and profit.
Hydrological functioning of thawing soil water in a permafrost‐influenced alpine meadow hillslope
Authors: Xiao Xiong , Zhang Fan , Li Xiaoyan , Wang Guanxing , Zeng Chen , Shi Xiaonan 
Published: April 2020

AbstractThe complex variation of the hydrological functioning of soil water has been widely studied using measurements of the stable isotopic composition of either the bulk soil water (BSW) collected by the cryogenic vacuum extraction method or the mobile soil water (MSW) collected by the zero‐tension soil lysimeter method. We collected samples of precipitation, BSW, MSW, and hillslope runoff in an alpine meadow hillslope influenced by permafrost to investigate the hydrological functioning of thawing soil water. The results showed that the δ2H values in BSW were generally more negative than those of the MSW, which may be a result of the depleted spring snowmelt that formed the tightly bound soil water. The relatively stable characteristics of δ2H in the MSW were related to the dynamic mixing of newly infiltrated precipitation with slightly enriched mobile water held by the low soil matrix potential. The δ2H values in the BSW showed higher temporal variations than the values in the MSW, which were mainly related to the mixing of depleted tightly bound soil water and enriched MSW in varying fractions. The MSW better represented the lateral subsurface flow (SSF, which further generated streamflow) than the BSW samples considering the relatively close stable isotopic values between the lateral SSF and the MSW in the same soil layer. The results of this study show the influences of the varying water level maintained by the underlying permafrost on the water and isotopic dynamics of both the soil water pools and streamflow.
Parameterization of a hydrologic model with geophysical data to simulate observed subsurface return flow paths
Authors: Claes Niels , Paige Ginger B. , Grana Dario , Parsekian Andrew D. 
Published: April 2020

AbstractA portion of water not consumed by crops during flood irrigation can flow back across the surface or through the subsurface to adjacent surface water bodies and streams as return flow. Few studies have directly addressed subsurface processes governing return flow and the importance of structural complexity on hydrologic process representation. It is challenging to measure and model these subsurface flow paths using traditional hydrologic observations. In this study, we assess the impact of subsurface structural complexity on vadose zone flow representation in a two‐dimensional transport model by varying structural complexity derived from background geophysical data. We assessed four model structures each with three soil types of homogeneous hydrologic properties, two of which were evaluated with and without an anisotropy factor. Wetting front arrival times, derived from time‐lapse electrical resistivity measurements during flood irrigation field experiments, were used to evaluate the different representations of soil profile structures. These data indicated both vertical and lateral preferential flow in the subsurface during flood irrigation. Inclusion of anisotropy in the saturated hydraulic conductivity field improved the ability to model subsurface hydrologic behavior when flow processes shifted from uniform to heterogeneous flow, as occurs with lateral subsurface return flow under flood irrigation driven by a large pressure gradient. This reduced the need for detailed spatial discretization to represent these observed subsurface flow processes. The resulting simple three‐layer model structure was better able to model both the vertical and lateral flow processes than a more complex geospatial structure, suggesting that overinterpretation of smoothed inverted profiles could lead to misrepresentation of the subsurface structure.
Synthetic NiO catalyst‐assisted peroxymonosulfate for degradation of benzoic acid from aqueous solution
Authors: Huo Xiaowei , Zhou Peng , Zhang Jing , Wei Chenmo , Liu Yunxin , Zhang Gucheng , Li Wenshu , Zhang Yongli 
Published: April 2020

AbstractA heterogeneous NiO catalyst was prepared by a precipitation process using nickel nitrate with oxalic acid and tested for heterogeneous oxidation of benzoic acid (BA) in the presence of peroxymonosulfate (PMS). It was found that the synthetic NiO is highly effective in heterogeneous activation of PMS to produce sulfate radicals (

) and hydroxyl radicals (·OH), and also presents stable performance in the heterogeneous activation of PMS for BA degradation. Physicochemical properties of the NiO catalyst were characterized by several techniques, such as thermogravimetric analysis, Brunauer‐Emmett‐Teller, Fourier transform infrared spectroscopy, X‐ray diffraction, X‐ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. It was found that NiO and NiOOH were formed on the synthetic NiO catalyst and were stably distributed on the catalyst surface. Nearly 95% decomposition could be achieved in 30 min at the conditions of 500 ml 20 μM BA solution, 0.25 g catalyst, and [PMS]:[BA] = 30:1. The heterogeneous reactions, the effects of PMS concentration, and catalyst dosage on the BA degradation were investigated. The heterogeneous BA degradation reactions followed first‐order kinetics. Additionally, quenching experiments proved that the dominant radical in the solution was ·OH. The experiments results also showed that this approach is effective for the degradation of many other pollutants (such as tetracycline hydrochloride, 2, 4‐dichlorophenol, Acid orange 7, rhodamine B, and methyl red).Practitioner points

A novel NiO material was fabricated for degradation of benzoic acid.

The synthetic NiO catalyst comprised active NiO and NiOOH.

The main radical for benzoic acid removal rate was ·OH.

A plausible mechanism for catalyzed degradation of the benzoic acid was proposed.
Characterization of wood-adhesive bonds in wet conditions by means
of nanoindentation and tensile shear strength
Authors: Bockel Stefan , Harling S. , Grönquist P. , Niemz P. , Pichelin F. , Weiland G. , Konnerth Johannes 
Published: April 2020

AbstractThe performance of adhesive-hardwood bonds can often be sensitive to
humidity and temperature variation. Therefore, it is frequently challenging to achieve
standard requirements for structural applications. To gain a better understanding of the
wood-adhesive bond, the properties of the individual constituents as well as the local
interface of European beech (Fagus sylvatica L.) wood
cell walls in contact with structural adhesives were analyzed by means of
nanoindentation. These results are compared to classical lap-shear strength. As
adhesives two different one-component polyurethane adhesives (1C PUR) and a phenol
resorcinol formaldehyde adhesive (PRF) were used. In one case, the beech wood was
additionally pre-treated with an adhesion-promoting agent (primer) prior to bonding with
1C PUR. Beech wood joints were analyzed subsequent to several treatments, namely
standard climate, after wet storage and in re-dried conditions. In addition, the
influence of the primer on the hydroxyl accessibility of beech wood was investigated
with dynamic vapor sorption (DVS). The lap-shear strength revealed good performance in
dry and re-dried conditions for all adhesives on beech. Both polyurethane adhesives
obtained deficits when tested in wet conditions. The use of a primer significantly
improved the PUR performance in wet condition. DVS experiment demonstrated a decrease in
hydroxyl group accessibility when using a high primer concentration. As novelty,
nanoindentation was used for the first time to characterize the local
wood–adhesive-interface properties in wet conditions. Nanoindentation showed that all
tested 1C PUR perform quite similar in room climate, while PRF achieves considerable
higher values for reduced E-modulus and hardness. Wet storage led to a considerable
reduction in mechanical properties for all adhesives, while the highest relative change
was observed for PRF. After re-drying, the adhesives re-gained a large part of their
original mechanical properties in room climate. No distinct effect of the primer on the
local micromechanical properties could be detected with nanoindentation in terms of
specific work of indentation.
Interaction between behavioral inhibition and neural alcohol cue-reactivity in ADHD and alcohol use disorder
Authors: Vollstädt-Klein S , Gerhardt S , Lee A , Strosche A , Sharafi G , Nuriyeva R , Seidt J , Hennig O , Alm B , Hermann D , Sommer WH , Kiefer F , Luderer M , Sobanski E 
Published: April 2020

Abstract
Rationale
Compared to the general population, adult Attention-Deficit / Hyperactivity Disorder (ADHD) is more prevalent in patients with Alcohol Use Disorder (AUD). Impaired behavioral inhibition is a common characteristic in both ADHD and AUD. Relapse risk is increased in patients with AUD and comorbid, untreated ADHD and in AUD patients with increased neural cue-reactivity.

Objectives
In this study, we examined the interaction between neural correlates of behavioral inhibition and alcohol cue-reactivity with a hybrid imaging task.

Methods
Out of 69 adult study participants, we included n = 49 in our final analyses: Individuals had a diagnosis of either AUD (n = 13), ADHD (n = 14) or both (n = 5), or were healthy controls (HC; n = 17). The functional magnetic resonance imaging paradigm aimed to examine the combined effects of both an interference-inhibition task (“Simon-task”) and an alcohol cue-reactivity task. Instead of segregating by diagnostic group, we pursued a dimensional approach in which we compared measures of AUD and ADHD severity, as well as the interaction of both, using multiple regression analyses.

Results
The four groups did not differ on the behavioral level on either the inhibition task or the alcohol cue-reactivity task. However, brain activation in frontal control and reward-related regions during completion of the combined tasks were related to ADHD and AUD severity (symptom load). During presentation of both alcohol cues and the inhibition task, participants with higher AUD and ADHD symptom load exhibited greater BOLD (blood oxygen level dependent) responses in subcortical reward-related regions.

Conclusions
Our findings support the hypothesis that ADHD additionally diminishes inhibition ability in individuals with AUD. This may increase relapse risk when confronted with alcohol cues. Further, it is crucial for patients with comorbid AUD and ADHD to take into account not only reduced cognitive control over behavioral inhibition but also simultaneously heightened alcohol cue-reactivity.
Valuable furan fatty acids in soybeans and soy products
Authors: Müller Franziska , Hogg Melanie , Vetter Walter 
Published: April 2020

AbstractFuran fatty acids (FuFAs) are valuable minor compounds in our food with excellent antioxidant properties. Naturally occurring FuFAs are characterised by a central furan moiety with one or two methyl groups in β-/β’-position of the heterocycle (monomethyl- or M-FuFAs and dimethyl- or D-FuFAs). Comparably high concentrations of D-/M-FuFAs were reported in soybeans, but soy is often consumed as a processed product, such as full-fat soy flour and flakes, soy drink, tofu and texturised soy protein (TSP). Due to the chemical lability of D-/M-FuFAs, e.g. in the presence of light or oxygen, a degradation during the processing is possible. For this purpose, freshly harvested soybeans (n = 4) and differently processed soybean products (n = 22) were analysed on FuFAs. Three FuFAs, i.e. 11-(3,4-dimethyl-5-pentylfuran-2-yl)-undecanoic acid (11D5), 9-(3,4-dimethyl-5-pentylfuran-2-yl)-nonanoic acid (9D5), and 9-(3-methyl-5-pentylfuran-2-yl)-nonanoic acid (9M5), were identified and quantified in all fresh soybeans and most of the processed soy products (n = 20). A trend towards lower D-/M-FuFA contents in higher processed products was observable. Lower FuFA concentrations were usually accompanied with a decrease of the share of the less stable D-FuFAs (9D5, 11D5) in favour of the M-FuFA 9M5. Furthermore, one or two 3,4-nonmethylated furan fatty acids (N-FuFAs), i.e. 8-(5-hexylfuran-2-yl)-octanoic acid (8F6) and partly 7-(5-heptylfuran-2-yl)-heptanoic acid (7F7), were detected in all processed products, but not in the freshly harvested soybeans. Our results indicate that D-/M-/N-FuFAs may serve as suitable markers for both, careful manufacturing processes and adequate storage conditions of soy products.