bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Dose and Low Dose Oxytocin Regimens as Determinants of Successful Labor Induction: A multicenter comparative study
Authors: TESEMMA MELESE GEZAHEGN , Sori Demisew Amenu , Gemeda Desta Hiko 
Published: December 2019

Abstract

Background: Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of induction. Methods: Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance. Result: The mean “Induction to delivery time” was 5.9 hours and 6.3 hours for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of < 4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction. Conclusions: In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction.We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction.
Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA
Authors: Liu Juejun , Chen Changzheng , Li Lu , Xu Yishuang , Yi Zuohuizi , He Lu , Zheng Hongmei 
Published: December 2019

Abstract
Background: To quantify flow changes in choriocapillaris (CC) in patients with chronic central serous chorioretinopathy (CCSC) in the treatment of half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA).Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. Proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA were mainly assessments in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA. Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up than 1-m follow-up (p=0.036). Comparing to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT can be identified, including signs of recovery with more even flow signals, transient appearance of worsen ischemia and secondary neovascularization within CC level. Conclusion: Abnormal CC flow attenuation remained in completely resolved eyes of CCSC patients treated with half-dose PDT. Key Words: Chronic; Central Serous Chorioretinopathy; Optical Coherence Tomography Angiography; Photodynamic Therapy
Anti-rheumatic treatment and prosthetic joint infection: An observational study in 494 elective hip and knee arthroplasties.
Authors: Borgas Ylva , Gülfe Anders , Kindt Mikael , Stefánsdóttir Anna 
Published: December 2019

Abstract
Background Surgical site infections are more frequent among patients with rheumatic disease. To which extent this is related to immunosuppressive antirheumatic drugs is unclear, as is the value of discontinuing medication perioperatively.Objectives To assess the rate of surgical site infections after knee and hip-replacement in patients with inflammatory joint disease, with emphasis on periprosthetic joint infection, and to investigate the importance of medical treatment in this regard.Methods Data was collected from 494 primary elective hip- (51.4%) and knee arthroplasties along with demographic and medication data and primary outcome was surgical site infections during the first year after surgery.Results In 78% (n=385) of the cases the patient medicated with 1 to 3 disease-modifying antirheumatic drugs perioperatively. Thirty two per cent (n=157) of patients were on a TNF-alpha inhibitor perioperatively. The rate of surgical site infections was 3.8% (n=19) The rate of periprosthetic joint infection was 1.4% (n=7), all of which were knee arthroplasties. Only in 1 case of periprosthetic joint infection the patient medicated perioperatively with a TNF-alpha inhibitor.Conclusion Surgical site infections was not associated with ongoing medication with disease-modifying antirheumatic drugs. Due to low event rate this should be interpreted with caution. Routines at our centre, not stopping biologic disease-modifying antirheumatic drugs perioperatively, will be unchanged.
Low cyclosporine concentrations in children and time to acute graft versus host disease
Authors: Chung Eun Kyung , Yee Jeong , Kim Jae Youn , Gwak Hye sun 
Published: December 2019

Abstract
Background Achievement of target blood concentrations of cyclosporine (CsA) early after transplantation is known to be highly effective for reducing the incidence of acute graft versus host disease (aGVHD). However, no research has been conducted for predicting elapsed time from low CsA concentration to aGVHD occurrence. The objective of this study was to investigate the risk of aGVHD according to elapsed time from low CsA concentrations in children with allogenic hematopoietic stem cell transplantation (HSCT). Methods The outcomes of 61 consecutive children who underwent allogeneic HSCT and received CsA as prophylaxis against aGVHD between May 2012 and March 2015 were retrospectively evaluated; the main outcome was any association between elapsed time from low CsA concentrations to aGVHD occurrence. Elapsed time was defined as follows: one week (0–6 days), two weeks (7–13 days), or three weeks (14–20 days), and the incidence of aGVHD was examined for the first three months after transplantation. ResultsIn children whose mean CsA concentration after the allogenic HSCT did not reach the initial target concentration, the adjusted odds ratio for developing aGVHD within one week was 12.3 (95% confidence interval [CI]: 2.7–56.0). The AORs for developing aGVHD between 7 and 13 days and between 14–20 days were 90.8 (95% CI: 8.3–999.9) and 28.1 (95% CI: 2.4–333.1), respectively. Conclusions Careful attention needs to be paid to the elapsed time after low CsA concentrations are detected to prevent aGVHD.
Effects of chalazion and its treatments on the meibomian glands: non-randomized, prospective observation clinical study
Authors: Li Junping , Li Dongping , Zhou Na , Qi Mengying , Luo Yanzhu , Wang Yuhong 
Published: December 2019

Abstract
Background To observe the effects of chalazion and its treatments on the meibomian gland function and morphology in chalazion area. Methods This non-randomized, prospective observation clinical study included 58 patients (67 eyelids) cured of chalazion, including 23 patients (23 eyelids) treated with conservative method, and 35 patients (44 eyelids) with surgery. Slit lamp microscopy, infrared meibomian gland photography and in vivo laser scanning confocal microscopy (LSCM) were performed before treatment and 1 month after the chalazion complete resolution. The meibomian gland function, the area proportion and acinar structure in the chalazion area were analyzed before and 1 month after the chalazion resolution.Results In patients with conservative treatment, the meibomian gland function parameters improved at 1 month after chalazion resolution compared to those before treatment (P<0.05). There was no significant statistical difference in meibomian gland functional parameters before and after surgery (P>0.05). According to infrared meibomian gland photography, after chalazion resolution, the area presented meibomian gland loss, there was no significant statistical difference between the proportion of meibomian gland loss at 1 month after chalazion resolution and the proportion of the initial chalazion area (P>0.05) regardless of the treatment strategy. The acinar structure could not be observed clearly after the chalazion complete resolution. Conclusions Chalazion will cause meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method, but the range of the chalazion itself. Hot compress in conservative treatment can improve the meibomian gland function that chalazion located in short term.
Quality of Life and its Related Factors in Iranian Addicted Women Referring to Substance Abuse Treatment Centers
Authors: Barati Majid , Bandehelahi Khadijeh , Nopasandasil Tahereh , Jormand Hanieh , Keshavarzi Amir 
Published: December 2019

Abstract
Background: Drug addiction is one of the most common social problems that is caused by the illegal use of addictive drugs; it affects the quality of life of substance users. Therefore, this study aimed at determine the quality of life and its related factors among addicted women referring to substance abuse treatment centers in Hamadan, west of Iran. Methods: This cross-sectional study was carried out on 120 Iranian female substance users recruited through census sampling method in 2018. Data collection tools consisted of demographic characteristics and quality of life questionnaire (SF-36). Data were analyzed using SPSS-16 via one way ANOVA and chi-square tests. Results: The mean age of the participants was 33.2 ± 12.1 years. The last drug used by the participants was methamphetamine (53.3%), methadone (20.8%), and heroin (12.5%), respectively. The mean score of total quality of life was 35.35 ± 13.5 that indicated unsatisfactory level. Moreover, there was a significant association between quality of life and age, educational level, place of residence, and job status (P<0.05). Conclusion: According to the results, the quality of life of the participants was found to be at unsatisfactory level. The identification of more vulnerable groups may increase the effectiveness of intervention programs.
The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study
Authors: Zhang Bin , Xu Ting , Yin Daqiang , Wei Sheng 
Published: December 2019

Abstract
Background Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies on the health effects and toxicity of BDE-209 focused on thyroid disruption, oxidative stress, neurotoxicity and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf) larvae, however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concertation exposures.Conclusion The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.
Validation of the Spanish version of Migraine Disability Assessment questionnaire (MIDAS) in migraine university students.
Authors: Rodríguez-Almagro Daniel , Achalandabaso Alexander , Rus Alma , Obrero-Gaitán Esteban , Zagalaz-Anula Noelia , Lomas-Vega Rafael 
Published: December 2019

Abstract
Background. The Migraine Disability Assessment (MIDAS) questionnaire is widely used for determining headache-related disability. However, to the best of our knowledge, there is no validated Spanish version of the questionnaire. It is composed of seven items; the first five items constitute the main scale, while the sixth and seventh items refer respectively to the frequency and intensity of headache. The present study is aimed at analyzing the clinimetric properties of the Spanish version of the MIDAS questionnaire in a population of university students.Methods. We performed a cross-sectional study of validation of measuring instruments. One hundred fifty-three subjects participated in the study. We analyzed construct validity by factor analysis, test-retest reliability by the Intraclass Correlation Coeficient (ICC), internal consistency, and concurrent validity with respect to the 12-Item Short Form Health Survey (SF-12).Results. Factor analysis showed a two factors structure composed. The questionnaire presented good reliability for the MIDAS-main scale score ([ICC = 0.81; 95% CI: 0.63 – 0.90]), excellent reliability for headache frequency (ICC = 0.90; 95%; CI: [0.79 – 0.95]), and moderate reliability for headache intensity (ICC = 0.63; 95% CI: [0.34 – 0.80]). The analysis also showed good internal consistency results (α Cronbach = 0.797) and a moderate correlation between MIDAS-main scale and physical summary component of SF-12 (Rho = -0.326; p < 0.001).Conclusions. The Spanish version of the MIDAS questionnaire is a valid and reliable tool to measure headache-related disability in university subjects. The two additional items provide information that could help clinicians in making decisions.
Implementation of the WHO Hand Hygiene Strategy in Faranah Regional Hospital, Guinea
Authors: Müller Sophie Alice , Diallo Alpha Oumar Karim , Wood Rebekah , Bayo Mouctar , Eckmanns Tim , Tounkara Ousmane , Arvand Mardjan , Diallo Mamadou , Borchert Matthias 
Published: December 2019

Abstract
Background: Healthcare-associated infections are the most frequent adverse events in healthcare worldwide, with limited available evidence suggesting highest burden in resource-limited settings. Recent Ebola epidemics emphasize the disastrous impact that spread of infectious agents within healthcare facilities can have, accentuating the need for improvement of infection control practices. Hand hygiene (HH) measures are considered to be the most effective tool to prevent Healthcare-associated infections. However, HH knowledge and compliance are low, especially in vulnerable settings such as Guinea. The aim of PASQUALE (Partnership to Improve Patient Safety and Quality of Care) was to assess knowledge and compliance with HH and improve HH by incorporating the WHO HH Strategy within the Faranah Regional Hospital (FRH), Guinea.Methods: In a participatory approach, a team of HRF staff and leadership was invited to identify priorities of the hospital prior to the start of PASQUALE. The local hygiene committee was empowered to increase its activities and take ownership of the HH improvement strategy. A baseline assessment of knowledge, perception and compliance was performed months before the intervention. The main intervention consisted of local alcohol-based-hand-rub (ABHR) production, with final product efficacy testing, in conjunction with a training adapted to the needs identified in the baseline assessment. A follow-up assessment was conducted directly after the training. Effectiveness of the intervention was assessed via uncontrolled before-and-after comparison.Results: Baseline knowledge score (13.0/25) showed a significant increase to 19.0/25 in follow-up. Baseline-Compliance was 23.7% and increased significantly to 71.5% in follow-up. Compliance rose significantly across all professional groups except for midwifes and in all indications for HH, with the largest in the indication “Before aseptic tasks”. The increase in compliance was associated with the intervention and remained significant after adjusting for confounders. The local pharmacy successfully supplies the entire hospital. The local supply resulted in a ten-fold increase of monthly hospital disinfectant consumption.Conclusion: The WHO HH strategy is an adaptable and effective method to improve HH knowledge and compliance in a resource-limited setting. Local production is a feasible method for providing self-sufficient supply of ABHR to regional hospitals like the FRH. Participatory approaches like hygiene committee ownership builds confidence of sustainability.
Rare diseases and mental health in the UK - a quantitative survey and multi-stakeholder workshop
Authors: Spencer-Tansley Rosa , Meade Nick , Ali Farhana , Simpson Amy , Hunter Amy 
Published: December 2019

Abstract
Background: Rare disease patients and carers report significant impacts on mental health but this has not been extensively studied. We explored the experiences of UK-based individuals through an online survey, and offer recommendations for policy and practice developed with a multi-stakeholder workshop.Results: In total 1,355 patients and 571 carers responded to the survey. Due to their rare condition, the majority of respondents had felt worried/anxious (95%); stressed (93%); low/depressed (90%); emotionally exhausted (88%). Thirty-six percent of patients and 19% of carers had had suicidal thoughts. Challenges that are particular to rare conditions and which negatively affect mental health included low knowledge of the condition amongst healthcare professionals (88%), not being believed or taken seriously by healthcare professionals (80%), and lack of available information about the condition (76%). Only 23% of respondents felt mental health was considered by healthcare professionals as equally important as physical health. Almost half of patients (46%) and carers (48%) reported never having been asked about their mental health, or that of the person they care for, by healthcare professionals. Forty-six percent of respondents had received professional psychological support; the most common reason for not having accessed professional psychological support was that it had not been suggested (41%). Fifty-nine percent of respondents had accessed sources of additional emotional support, such as patient groups, with the majority (75%) having found this support themselves. With input from our multi-stakeholder workshop we developed recommendations for healthcare professionals to be supported to effectively and sensitively recognise and address patients’ and carers’ mental health needs; and for service level coordination of care to integrate professional psychological support with rare disease services.Conclusions: Living with a rare disease can substantially impact mental health. Many of the drivers of poor mental health reflect issues specific to managing rare conditions. To meet existing UK government commitments, there should be a focus on empowering healthcare professionals who treat rare disease patients and on integration of mental health support with rare disease services.
Ethno-medicinal knowledge of a marginal hill community of Central Himalayas: Diversity, usage pattern and conservation concerns
Authors: Ojha Saraswati Nandan , Tiwari Deepti , Anand Aryan , Sundriyal R.C. 
Published: December 2019

Abstract
Background Human beings have been dependent on surrounding resources for their survival since time immemorial. Medicinal plants have been an important resource to cure various diseases and ailments. Unfortunately, the knowledge is depleting fast thus deserves to be documented for its proper use. The present study reports ethnomedicinal know-how of a mountain community from central Himalayas of India. Methodology Extensive field visits were made to gather information on ethnomedicinal use of plant species in Bageshwar district of Uttarakhand, central Himalayas. Initial survey was done in 73 villages to assess the key persons engaged in herbal healing practices as well as its usage. A total of 100 such persons were identified (70 non-healers/natives and 30 vaidyas ) and finally interviewed using semi-structured questionnaires, target interviews and group discussion. Various indices were also used to evaluate the ethno-medicinal data. Result This study revealed the ethno-medicinal plant diversity, traditional medicinal practices of local herbal practitioners and past and present scenario of ethno-medicinal cure system. A total of 70 medicinal plants used to cure diseases varying from general health care to a few complex ailments with a documented use-report ranging from 03 to 94 and their cultural importance as high as 0.97 within different taxon. A total of 35 families of such medicinal plants were recorded from traditional healers, vaidyas and marginal hill community. This type of knowledge being passed on verbally to generations needs to be preserved for the future bio-prospecting of plants that could be a potential cure to any future disease. Further ethno-botanical indices were employed in the study to analyze the relevance of the study. Conclusion The present study examines the medicinal plants that are available in the vicinity of the community or sometimes grown as daily edible food, providing an effective and affordable treatment to the marginal class of hill community. Such traditional knowledge of the community has enough relevance to provide with them, a sustainable approach which otherwise may create a disarray in conservation efforts leading to human induced intervention efforts in future.