bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of evidence-based practice for alcohol and substance use disorders: protocol for systematic review
Authors: Louie Eva , Barrett Emma L. , Baillie Andrew , Haber Paul , Morley Kirsten C. 
Published: February 2020

Abstract
Background
Whilst effective treatments exist for substance use and alcohol use disorders, they are not commonly practised. Studies have shown that only a small percentage of services provide evidence-based treatments such as addiction medications or psychosocial therapies. Although there is a growing body of literature on evidence-based treatment, no synthesis of research on the implementation of evidence-based addiction treatment exists. This proposed systematic review will synthesise and evaluate the effectiveness of implementation programmes in the treatment of patients with drug and alcohol problems using the Consolidated Framework for Implementation Research (CFIR) framework.

Methods
We will search (from inception onwards) PubMed/MEDLINE, Cochrane Library, PsycINFO, Web of Science and CINAHL. Eligible studies will be clinical trials (e.g. randomised controlled trials, non-randomised controlled trials) and observational studies (e.g. before-and-after studies, interrupted time series) evaluating strategies used to implement evidence-based psychosocial treatments for alcohol and substance use disorders. The primary outcomes will be related to the implementation, service system, or clinical practice (e.g. acceptability, implementation costs, feasibility). Two researchers will independently screen all citations, full-text articles and abstract data. Risk of bias of individual studies will be appraised using appropriate tools. A narrative synthesis will be provided.

Discussion
This project aims to provide evidence to help guide the design of translational research programmes to improve implementation of evidence-based care in drug and alcohol settings. Findings from the study will specify effective strategies for domains of influence including (1) intervention characteristics (e.g. evidence strength and quality, adaptability), (2) outer setting (e.g. patient needs and resources, external policies and incentives), (3) inner setting (e.g. implementation climate, readiness for implementation), (4) individuals involved (e.g. self-efficacy, knowledge and beliefs about the intervention) and (5) the implementation process (e.g. engaging members of the organisation, executing the innovation). Identified gaps in knowledge will guide further study.

Systematic review registration
PROSPERO CRD42019123812
Global attractiveness and exponential stability for impulsive fractional neutral stochastic evolution equations driven by fBm
Authors: Liu Jiankang , Xu Wei , Guo Qin 
Published: February 2020

AbstractThis paper is concerned with a class of fractional neutral stochastic integro-differential equations with impulses driven by fractional Brownian motion (fBm). First, by means of the resolvent operator technique and contraction mapping principle, we can directly show the existence and uniqueness result of mild solution for the aforementioned system. Then we develop a new impulsive-integral inequality to obtain the global attracting set and pth moment exponential stability for this type of equation. Worthy of note is that this powerful inequality after little modification is applicable to the case with delayed impulses. Moreover, sufficient conditions which guarantee the pth moment exponential stability for some pertinent systems are stated without proof. In the end, an example is worked out to illustrate the theoretical results.
The plethora of explicit solutions of the fractional KS equation through liquid–gas bubbles mix under the thermodynamic conditions via Atangana–Baleanu derivative operator
Authors: Yue Chen , Khater Mostafa M. A. , Attia Raghda A. M. , Lu Dianchen 
Published: February 2020

AbstractNovel explicit wave solutions are constructed for the Kudryashov–Sinelshchikov (KS) equation through liquid–gas bubbles mix under the thermodynamic conditions. A new fractional definition (Atangana–Baleanu derivative operator) is employed through the modified Khater method to get new wave solutions in distinct types of this model that is used to describe the phenomena of pressure waves through liquid–gas bubbles mix under the thermodynamic conditions. The stability property of the obtained solutions is tested to show the ability of our obtained solutions through the physical experiments. The novelty and advantage of the proposed method are illustrated by applying to this model. Some sketches are plotted to show more about the dynamical behavior of this model.
Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss
Authors: Haange Sven-Bastiaan , Jehmlich Nico , Krügel Ute , Hintschich Constantin , Wehrmann Dorothee , Hankir Mohammed , Seyfried Florian , Froment Jean , Hübschmann Thomas , Müller Susann , Wissenbach Dirk K. , Kang Kang , Buettner Christian , Panagiotou Gianni , Noll Matthias , Rolle-Kampczyk Ulrike , Fenske Wiebke , von Bergen Martin 
Published: February 2020

AbstractBackgroundRoux-en-Y gastric bypass (RYGB) surgery is a last-resort treatment to induce substantial and sustained weight loss in cases of severe obesity. This anatomical rearrangement affects the intestinal microbiota, but so far, little information is available on how it interferes with microbial functionality and microbial-host interactions independently of weight loss.MethodsA rat model was employed where the RYGB-surgery cohort is compared to sham-operated controls which were kept at a matched body weight by food restriction. We investigated the microbial taxonomy and functional activity using 16S rRNA amplicon gene sequencing, metaproteomics, and metabolomics on samples collected from theileum, the cecum, and the colon, and separately analysed the lumen and mucus-associated microbiota.ResultsAltered gut architecture in RYGB increased the relative occurrence ofActinobacteria, especiallyBifidobacteriaceaeandProteobacteria, while in general,Firmicuteswere decreased althoughStreptococcaceaeandClostridium perfringenswere observed at relative higher abundances independent of weight loss. A decrease of conjugated and secondary bile acids was observed in the RYGB-gut lumen. The arginine biosynthesis pathway in the microbiota was altered, as indicated by the changes in the abundance of upstream metabolites and enzymes, resulting in lower levels of arginine and higher levels of aspartate in the colon after RYGB.ConclusionThe anatomical rearrangement in RYGB affects microbiota composition and functionality as well as changes in amino acid and bile acid metabolism independently of weight loss. The shift in the taxonomic structure of the microbiota after RYGB may be mediated by the resulting change in the composition of the bile acid pool in the gut and by changes in the composition of nutrients in the gut.
Effects of age on foraging behavior in two closely related albatross species
Authors: Frankish Caitlin K. , Manica Andrea , Phillips Richard A. 
Published: February 2020

AbstractBackgroundForaging performance is widely hypothesized to play a key role in shaping age-specific demographic rates in wild populations, yet the underlying behavioral changes are poorly understood. Seabirds are among the longest-lived vertebrates, and demonstrate extensive age-related variation in survival, breeding frequency and success. The breeding season is a particularly critical phase during the annual cycle, but it remains unclear whether differences in experience or physiological condition related to age interact with the changing degree of the central-place constraint in shaping foraging patterns in time and space.MethodsHere we analyze tracking data collected over two decades from congeneric black-browed (BBA) and grey-headed (GHA) albatrosses,Thalassarche melanophrisandT. chrysostoma, breeding at South Georgia. We compare the foraging trip parameters, at-sea activity (flights and landings) and habitat preferences of individuals aged 10–45 years and contrast these patterns between the incubation and early chick-rearing stages.ResultsYoung breeders of both species showed improvements in foraging competency with age, reducing foraging trip duration until age 26. Thereafter, there were signs of foraging senescence; older adults took gradually longer trips, narrowed their habitat preference (foraging within a smaller range of sea surface temperatures) (GHA), made fewer landings and rested on the water for longer (BBA). Some age-specific effects were apparent for each species only in certain breeding stages, highlighting the complex interaction between intrinsic drivers in determining individual foraging strategies.ConclusionsUsing cross-sectional data, this study highlighted clear age-related patterns in foraging behavior at the population-level for two species of albatrosses. These trends are likely to have important consequences for the population dynamics of these threatened seabirds, as young or old individuals may be more vulnerable to worsening environmental conditions.
Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease
Authors: Crevier-Sorbo Gabriel , Rymar Vladimir V. , Crevier-Sorbo Raphael , Sadikot Abbas F. 
Published: February 2020

AbstractHuntington’s disease (HD) is an autosomal dominant trinucleotide repeat disorder characterized by choreiform movements, dystonia and striatal neuronal loss. Amongst multiple cellular processes, abnormal neurotransmitter signalling and decreased trophic support from glutamatergic cortical afferents are major mechanisms underlying striatal degeneration. Recent work suggests that the thalamostriatal (TS) system, another major source of glutamatergic input, is abnormal in HD although its phenotypical significance is unknown. We hypothesized that TS dysfunction plays an important role in generating motor symptoms and contributes to degeneration of striatal neuronal subtypes. Our results using the R6/2 mouse model of HD indicate that neurons of the parafascicular nucleus (PF), the main source of TS afferents, degenerate at an early stage. PF lesions performed prior to motor dysfunction or striatal degeneration result in an accelerated dystonic phenotype and are associated with premature loss of cholinergic interneurons. The progressive loss of striatal medium spiny neurons and parvalbumin-positive interneurons observed in R6/2 mice is unaltered by PF lesions. Early striatal cholinergic ablation using a mitochondrial immunotoxin provides evidence for increased cholinergic vulnerability to cellular energy failure in R6/2 mice, and worsens the dystonic phenotype. The TS system therefore contributes to trophic support of striatal interneuron subtypes in the presence of neurodegenerative stress, and TS deafferentation may be a novel cell non-autonomous mechanism contributing to the pathogenesis of HD. Furthermore, behavioural experiments demonstrate that the TS system and striatal cholinergic interneurons are key motor-network structures involved in the pathogenesis of dystonia. This work suggests that treatments aimed at rescuing the TS system may preserve important elements of striatal structure and function and provide symptomatic relief in HD.
Reproduction of East-African bats may guide risk mitigation for coronavirus spillover
Authors:   PREDICT Consortium, Montecino-Latorre Diego , Goldstein Tracey , Gilardi Kirsten , Wolking David , Van Wormer Elizabeth , Kazwala Rudovick , Ssebide Benard , Nziza Julius , Sijali Zikankuba , Cranfield Michael , Mazet Jonna A. K. 
Published: February 2020

Abstract
Background
Bats provide important ecosystem services; however, current evidence supports that they host several zoonotic viruses, including species of the Coronaviridae family. If bats in close interaction with humans host and shed coronaviruses with zoonotic potential, such as the Severe Acute Respiratory Syndrome virus, spillover may occur. Therefore, strategies aiming to mitigate potential spillover and disease emergence, while supporting the conservation of bats and their important ecological roles are needed. Past research suggests that coronavirus shedding in bats varies seasonally following their reproductive cycle; however, shedding dynamics have been assessed in only a few species, which does not allow for generalization of findings across bat taxa and geographic regions.

Methods
To assess the generalizability of coronavirus shedding seasonality, we sampled hundreds of bats belonging to several species with different life history traits across East Africa at different times of the year. We assessed, via Bayesian modeling, the hypothesis that chiropterans, across species and spatial domains, experience seasonal trends in coronavirus shedding as a function of the reproductive cycle.

Results
We found that, beyond spatial, taxonomic, and life history differences, coronavirus shedding is more expected when pups are becoming independent from the dam and that juvenile bats are prone to shed these viruses.

Conclusions
These findings could guide policy aimed at the prevention of spillover in limited-resource settings, where longitudinal surveillance is not feasible, by identifying high-risk periods for coronavirus shedding. In these periods, contact with bats should be avoided (for example, by impeding or forbidding people access to caves). Our proposed strategy provides an alternative to culling – an ethically questionable practice that may result in higher pathogen levels – and supports the conservation of bats and the delivery of their key ecosystem services.
Effect of direct-acting antivirals on corrected QT interval and cardiac functions in patients with chronic hepatitis C virus infection
Authors: Ibrahim Mohamed Gamal , Sharafeldin Ahmed Abdelrahman , Mousa Nevine Ibrahim , Mousa Tarek Khairy , El Missiri Ahmed Mohamed 
Published: February 2020

Abstract
Background
Hepatitis C virus (HCV) infection is a major public health problem in Egypt. The use of direct-acting antivirals (DAAs) in such patients has been shown to be highly effective. The cardiac safety of such antivirals remains uncertain. This study aimed to assess the effect of the novel DAAs on corrected QT (QTc) interval and on cardiac function using trans-thoracic echocardiography.

Results
This was a prospective cohort study performed on 100 patients suffering from chronic HCV infection. Patients were into two equal groups according to the presence of liver cirrhosis. The group without liver cirrhosis received a daily combination of sofosbuvir 400 mg and daclatasvir 60 mg for 12 weeks while that with liver cirrhosis (Child-Pugh score A or B) received a daily combination of sofosbuvir 400 mg, daclatasvir 60 mg, and ribavirin 600 mg for 12 weeks. Surface ECG and trans-thoracic echocardiography were performed prior to the start of treatment and after 12 weeks of treatment.
At the end of treatment, no changes were observed in QTc interval in those with (p = 0.48) or without (p = 0.048) liver cirrhosis. In patients without liver cirrhosis, right ventricular global longitudinal strain (RV GLS) decreased from 22 (−30 to −17) to −21 (−27–18), p = 0.024. In patients with liver cirrhosis, lateral mitral E’ velocity was reduced from 14.38 ± 3.59 to 13.62 ± 3.21 cm/s, p = 0.02 and indexed left atrial volume (LAVI) was increased from 25.96 ± 3.96 to 26.86 ± 4.12 ml/m2, p = 0.032. There were no changes in both groups regarding left ventricular (LV) dimensions, ejection fraction, trans-mitral E/A ratio, E/E’ ratio, deceleration time, right ventricular (RV) systolic pressure, mean pulmonary artery pressure, RV fractional area change, tricuspid annular plane systolic excursion, and LV GLS.

Conclusion
The current national protocol of HCV infection treatment with direct-acting antiviral agents used in Egyptian patients has a good cardiac safety profile. Such treatments have no effect on QTc interval, left and right ventricular functions except for a decrease in RV GLS in those with no liver cirrhosis and a reduction in lateral mitral E’ velocity in those with liver cirrhosis both remained within the normal reference range.
Brain structure and symptom dimensions in borderline personality disorder
Authors: Nenadić Igor , Voss Annika , Besteher Bianca , Langbein Kerstin , Gaser Christian 
Published: February 2020

Abstract

Background.
Borderline personality disorder (BPD) presents with symptoms across different domains, whose neurobiology is poorly understood.

Methods.
We applied voxel-based morphometry on high-resolution magnetic resonance imaging scans of 19 female BPD patients and 50 matched female controls.

Results.
Group comparison showed bilateral orbitofrontal gray matter loss in patients, but no significant changes in the hippocampus. Voxel-wise correlation of gray matter with symptom severity scores from the Borderline Symptom List (BSL-95) showed overall negative correlation in bilateral prefrontal, right inferior temporal/fusiform and occipital cortices, and left thalamus. Significant (negative) correlations with BSL-95 subscores within the patient cohort linked autoaggression to left lateral prefrontal and insular cortices, right inferior temporal/temporal pole, and right orbital cortex; dysthymia/dysphoria to right orbitofrontal cortex; self-perception to left postcentral, bilateral inferior/middle temporal, right orbitofrontal, and occipital cortices. Schema therapy-based Young Schema Questionnaire (YSQ-S2) scores of early maladaptive schemas on emotional deprivation were linked to left medial temporal lobe gray matter reductions.

Conclusions.
Our results confirm orbitofrontal structural deficits in BPD, while providing a framework and preliminary findings on identifying structural correlates of symptom dimensions in BPD, especially with dorsolateral and orbitofrontal cortices.
Tremor, Tick, and Trance: Siegfried Kracauer and Gregory Bateson in the Film Library of the Museum of Modern Art
Authors: Ponten Frederic 
Published: February 2020

AbstractThis article details the brief collaboration between Siegfried Kracauer and Gregory Bateson in the Film Library of the Museum of Modern Art during World War II as an intriguing episode in intellectual history, touching on film and media studies, anthropology, and German studies. The article presents the Frankfurt School as part of the 1940s’ memorandum culture and thereby attempts to situate the historiography of critical theory during this formative period within a broader intellectual landscape, that is, in dialogue and competition with several other projects, to analyze the Nazi German enemy, in this case, the Culture and Personality School. The article takes Kracauer’s and Bateson’s analyses of the Nazi movie Hitlerjunge Quex as a case in point and, with the help of institutional and biographical contextualization, develops some of their most important methodical innovations and insights into Nazi German propaganda. In particular, the article points to Kracauer’s concept of hypnosis and relates it to Bateson’s media theory.
Simultaneous generation of ultrabroadband noise-like pulses and intracavity third harmonic at 2  µm
Authors: Li Yuhang , Kang Yi , Guo Xin , Tong Limin 
Published: February 2020

We demonstrated that ultrabroadband noise-like pulses (NLPs) spanning from below 1600 nm to beyond 2300 nm can be generated in Tm-doped fiber lasers enabled by an optical microfiber. Meanwhile, pronounced red light around 660 nm was also observed, which was attributed to the intracavity third harmonic generation (THG) of ultrashort pulses by harnessing the intermodal phase matching in the optical microfiber. As far as we know, it is the first time to simultaneously observe the ultrabroadband NLPs and the intracavity THG in ultrafast fiber lasers, and it is anticipated that these ultrabroadband NLPs can be adopted as a compact broadband source for optical spectroscopy around 2 µm and a wonderful potential seed for supercontinuum generation in the mid-infrared. Moreover, the THG of the intracavity high peak power NLPs in ultrafast fiber lasers provides a new kind of fiber-format visible light source.
Mechanisms of Resistance to Mitogen-Activated Protein Kinase Pathway Inhibition in BRAF-Mutant Melanoma
Authors: Goetz Eva M. , Garraway Levi A. 
Published: February 2020

Overview: Anticancer drug resistance remains a crucial impediment to the care of many patients with cancer. Although the exact mechanisms of resistance may differ for each therapy, common mechanisms of resistance predominate, including drug inactivation or modification, mutation of the target protein, reduced drug accumulation, or bypass of target inhibition. With the discovery and use of targeted therapies (such as small-molecule kinase inhibitors), resistance has received renewed attention—especially in light of the dramatic responses that may emerge from such therapeutics in particular genetic or molecular contexts. Recently, the mitogen-activated protein kinase (MAPK) pathway has become exemplary in this regard, since it is activated in many different cancers. Drugs targeting RAF and MAPK kinase (MEK) are currently in clinical trials for the treatment of several types of cancer. Vemurafenib, a selective RAF kinase inhibitor recently approved for the treatment of BRAF(V600E) melanoma, shows strong efficacy initially; however, the development of resistance is nearly ubiquitous. In vitro testing and analysis of patient samples have uncovered several mechanisms of resistance to RAF inhibition. Surprisingly, mutations in the drug-binding pocket have not thus far been observed; however, other alterations at the level of RAF, as well as downstream activation of MEK and bypass of MEK/extracellular signal-regulated kinase (ERK) signaling altogether, confer resistance to vemurafenib. Looking forward, combined RAF and MEK inhibitor treatments may improve efficacy—yet we must anticipate mechanisms of resistance to this combination as well. Therefore, understanding and/or determining the mechanism of resistance are paramount to effective cancer treatment.
The Evolving Landscape of Metastatic Renal Cell Carcinoma
Authors: Heng Daniel Y. C. , Choueiri Toni K. 
Published: February 2020

Overview: The treatment paradigm in metastatic renal cell carcinoma (mRCC) has evolved over the last 5 years. There are now seven approved targeted therapies against the vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. The use of targeted therapy, sequences, combinations, and investigational compounds will be discussed. Prognostic and predictive tools are detailed, although much work must be done to find predictive biomarkers in an effort to individualize therapy for patients.
How to Decide Whether to Offer and Use “Nonstandard” Therapies in Patients with Advanced Sarcomas and Gastrointestinal Stromal Tumors: Global Variations in Clinical Practice, Assessment, and Access to Therapies in Diseases with Limited Incidence and Data
Authors: Sleijfer Stefan , Judson Ian , Demetri George D. 
Published: February 2020

Overview: As cancer is more generally recognized as a collection of various rare diseases rather than a homogeneous illness, sarcomas have become a model for the manner in which data can and cannot be used to drive clinical decision making. In this article, we explore the limitations of data generated in rare diseases such as sarcomas to provide an evidence base for clinical practice. How should patients be treated if there is no “standard” that offers “proof” of clinical benefit? By asking this question, we also raise the issue of what constitutes “clinical benefit”—and how to measure that—for patients with sarcomas and other rare diseases. As physicians become more accountable for decisions—and yet are always accountable to the patients and families who rely on them to provide the best and most appropriate care—oncologists must be cognizant of the limitations of data in rare diseases and be ready to justify actions that are in the best medical and social interests of patients.