bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photovoltaic lifetime forecast model based on degradation patterns
Authors: Kaaya Ismail , Lindig Sascha , Weiss Karl‐Anders , Virtuani Alessandro , Sidrach de Cardona Ortin Mariano , Moser David 
Published: July 2020

AbstractThe ever‐growing secondary market of photovoltaic (PV) systems (i.e., the transaction of solar plants ownership) calls for reliable and high‐quality long‐term PV degradation forecasts to mitigate the financial risks. However, when long‐term PV performance degradation forecasts are required after a short time with limited degradation history, the existing physical and data‐driven methods often provide unrealistic degradation scenarios. Therefore, we present a new data‐driven method to forecast PV lifetime after a small performance degradation of only 3%. To achieve an accurate and reliable forecast, the developed method addresses the fundamental challenges that usually affect long‐term degradation evaluation such as data treatment, choosing a good degradation model, and understanding the different degradation patterns. In the paper, we propose and describe an algorithm for degradation trend evaluation, a new concept of multiple “time‐ and degradation pattern‐dependent” degradation factors. The proposed method has been calibrated and validated using different PV modules and systems data of 5 to 35 years of field exposure. The model has been benchmarked against existing statistical models evaluating 11 experimental PV systems with different technologies. The key advantage of our model over statistical ones is the ability to perform more reliable forecasts with limited degradation history. With an average relative uncertainty of 7.0%, our model is outstanding in consistency for different forecasting time horizons. Moreover, the model is applicable to all PV technologies. The proposed method will aid in making reliable financial decisions and also in adequately planning operation and maintenance activities.
Persistence targeted smoking cessation for smokers with schizophrenia or schizoaffective disorder: a feasibility study
Authors: Steinberg Marc L. , Billingsley Benjamin , Rosen Rachel , Epstein Elizabeth E. , Lu Shou-En , Weickert Nicole , Williams Jill M. 
Published: July 2020

AbstractIntroductionIndividuals with schizophrenia are more likely to smoke and less likely to quit smoking than those without schizophrenia. Because task persistence is lower in smokers with than without schizophrenia, it is possible that lower levels of task persistence may contribute to greater difficulties in quitting smoking observed among smokers with schizophrenia.AimsTo develop a feasible and acceptable intervention for smokers with schizophrenia.MethodsParticipants (N = 24) attended eight weekly individual cognitive behavioral therapy sessions for tobacco use disorder with a focus on increasing task persistence and received 10 weeks of nicotine patch.ResultsIn total, 93.8% of participants rated the intervention as at least a 6 out of 7 regarding how ‘easy to understand’ it was and 81.3% rated the treatment as at least a 6 out of 7 regarding how helpful it was to them. A total of 62.5% attended at least six of the eight sessions and session attendance was positively related to nicotine dependence and age and negatively related to self-efficacy for quitting.DiscussionThis intervention was feasible and acceptable to smokers with schizophrenia. Future research will examine questions appropriate for later stages of therapy development such as initial efficacy of the intervention and task persistence as a mediator of treatment outcome.
Gen Z, Gender, and COVID-19
Authors: Deckman Melissa , McDonald Jared , Rouse Stella , Kromer Mileah 
Published: July 2020

AbstractUsing a national survey of Generation Z conducted in late May 2020, we measure attitudes about the impact of the coronavirus on personal health, financial and job concerns, views about shelter-in-place laws, and 2020 voting intentions. Gen Z women express greater health and economic concerns and support for shelter-in-place measures than their male counterparts, but this gender gap is largely mitigated by party and other covariates. Party also mediates the differences between young male and female voters concerning the influence of the coronavirus on their vote choice in 2020. Notably, women have significantly greater concern about the impact of COVID-19 on their personal financial situation, while Gen Z men express more concern about their personal health amid COVID-19 in more fully specified statistical models. This research contributes to the growing literature that examines not only the sorting effect of party on the gender gap but also how different identities—in this case, generation—can help explain the persistent political divides between men and women.
Bootstrap Aggregation and Cross‐Validation Methods to Reduce Overfitting in Reservoir Control Policy Search
Authors: Brodeur Zachary P. , Herman Jonathan D. , Steinschneider Scott 
Published: July 2020

AbstractPolicy search methods provide a heuristic mapping between observations and decisions and have been widely used in reservoir control studies. However, recent studies have observed a tendency for policy search methods to overfit to the hydrologic data used in training, particularly the sequence of flood and drought events. This technical note develops an extension of bootstrap aggregation (bagging) and cross‐validation techniques, inspired by the machine learning literature, to improve reservoir control policy performance on out‐of‐sample hydrological sequences. We explore these methods using a case study of Folsom Reservoir, California, using control policies structured as binary trees, and streamflow resampling based on the paleo‐inflow record. Results show that calibration‐validation strategies for policy selection coupled with certain ensemble aggregation methods can improve out‐of‐sample performance in water supply and flood risk objectives over baseline performance given fixed computational costs. Our findings highlight the potential to improve policy search methodologies by leveraging these well‐established model training strategies from machine learning.
Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway
Authors: Wang Yifan , Liao Ruocen , Chen Xingyu , Ying Xuhua , Chen Guanping , Li Mingqian , Dong Chenfang 
Published: July 2020

AbstractBreast cancer is considered to be the most prevalent cancer in women worldwide, and metastasis is the primary cause of death. Protease-activated receptor 1 (PAR1) is a GPCR family member involved in the invasive and metastatic processes of cancer cells. However, the functions and underlying mechanisms of PAR1 in breast cancer remain unclear. In this study, we found that PAR1 is highly expressed in high invasive breast cancer cells, and predicts poor prognosis in ER-negative and high-grade breast cancer patients. Mechanistically, Twist transcriptionally induces PAR1 expression, leading to inhibition of Hippo pathway and activation of YAP/TAZ; Inhibition of PAR1 suppresses YAP/TAZ-induced epithelial-mesenchymal transition (EMT), invasion, migration, cancer stem cell (CSC)-like properties, tumor growth and metastasis of breast cancer cells in vitro and in vivo. These findings suggest that PAR1 acts as a direct transcriptionally target of Twist, can promote EMT, tumorigenicity and metastasis by controlling the Hippo pathway; this may lead to a potential therapeutic target for treating invasive breast cancer.
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells
Authors: Du Shihao , Song Xiaoyu , Li Yuan , Cao Yalei , Chu Fuhao , Durojaye Olanrewaju Ayodeji , Su Zeqi , Shi Xiaoguang , Wang Jing , Cheng Juan , Wang Tangshun , Gao Xiang , Chen Yan , Zeng Wuzhekai , Wang Fengsong , Wang DongMei , Liu Xing , Ding Xia 
Published: July 2020

AbstractProgression of hepatocellular carcinoma involves multiple genetic and epigenetic alterations that promote cancer invasion and metastasis. Our recent study revealed that hyperphosphorylation of ezrin promotes intrahepatic metastasis in vivo and cell migration in vitro. Celastrol is a natural product from traditional Chinese medicine which has been used in treating liver cancer. However, the mechanism of action underlying celastrol treatment was less clear. Here we show that ROCK2 is a novel target of celastrol and inhibition of ROCK2 suppresses elicited ezrin activation and liver cancer cell migration. Using cell monolayer wound healing, we carried out a phenotype-based screen of natural products and discovered the efficacy of celastrol in inhibiting cell migration. The molecular target of celastrol was identified as ROCK2 using celastrol affinity pull-down assay. Our molecular docking analyses indicated celastrol binds to the active site of ROCK2 kinase. Mechanistically, celastrol inhibits the ROCK2-mediated phosphorylation of ezrin at Thr567 which harnesses liver cancer cell migration. Our findings suggest that targeting ROCK2-ezrin signaling is a potential therapeutic niche for celastrol-based intervention of cancer progression in hepatocellular carcinoma.
Begründung für die neuen LDL-Cholesterin-Zielwerte
Authors: Otto Sylvia , Schulze P. Christian , Weingärtner Oliver 
Published: July 2020

ZusammenfassungDie aktualisierte Dyslipidämie-Leitlinie von 2019 definiert noch tiefere Therapieziele in Abhängigkeit der individuellen Risikokategorie, sowohl für die Primär- als auch für die Sekundärprävention. LDL-Cholesterin bleibt das primäre Maß zur Risikoabschätzung und Haupt-Therapieziel. Daneben sollte Lp(a) einmal im Erwachsenenalter zur Identifikation von Risikopersonen bestimmt werden. Die letzten großen randomisierten Studien zu Ezetimib und PCSK9-Inhibitoren konnten eine weitere relative Risikoreduktion für kardiovaskuläre Ereignisse nachweisen. Dabei ist die Verringerung des kardiovaskulären Risikos proportional zur absoluten LDL-C-Senkung. Für Patienten mit sehr hohem Risiko ist das neue LDL-C-Ziel < 1,4 mmol/l (55 mg/dl) bzw. eine zusätzliche prozentuale Reduktion des LDL-C-Ausgangswerts um ≥ 50%. Eine ausreichende zelluläre Cholesterinversorgung besteht bei LDL-Spiegeln von nur 25 mg/dl (0,65 mmol/l), wie sie zur Geburt vorliegen.
Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer
Authors: Khalesi Rayhaneh , Abbasi Mahdi , Shahidi Zahra , Tabatabaei Masoumeh Hasani , Moradi Zohreh 
Published: July 2020

Abstract
Objectives Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer.
Materials and Methods This in vitro study was conducted on two groups of dental and polymer substrates. Each substrate was bonded to three indirect composite resins. Sixty blocks (3 × 3 × 12 mm) were made of sound bovine anterior teeth and PEEK polymer. Sixty blocks (3 × 3 × 12 mm) were fabricated of CRIOS (Coltene, Germany), high impact polymer composite (HIPC; Bredent, Germany), and GRADIA (Indirect; GC, Japan) composite resins. Composites were bonded to dentin using Panavia F 2.0 (Kuraray, Japan). For bonding to PEEK, Combo.lign (Bredent) and Visio.Link (Bredent) luting cements were used. In all samples, a single-edge notch was created by a no. 11 surgical blade at the interface. The samples were subjected to 3,500 thermal cycles, and their fracture toughness was measured in a universal testing machine (Zwick/Roell, Germany) by application of four-point flexural load.
Statistical Analysis Data were analyzed using one-way analysis of variance, Kruskal–Wallis.
Results The fracture toughness of CRIOS–PEEK interface was significantly higher than HIPC–PEEK. The fracture toughness of GRADIA–PEEK was not significantly different from that of HIPC and CRIOS. The fracture toughness of GRADIA–dentin was significantly higher than HIPC–dentin.
Conclusion Considering the limitations of this study, GRADIA has the highest bond strength to dentin, while CRIOS shows the highest bond strength to PEEK.
Mental Health for Men Who Have Sex with Men (MSM) and Women Who Have Sex with Women (WSW)
Authors: Salomaa Anna C. , Matsick Jes L. 
Published: July 2020

AbstractThis chapter reviews mental health research of sexual minorities who are defined by their same-gender sexual behavior. Women who have sex with women (WSW) and men who have sex with men (MSM) encompass not only those who identify as LGBQ+ but also people who identify as heterosexual or are unsure of their sexual orientation. The authors discuss the implications of this broad categorization on the study of mental disorders and psychological distress and present the typical rates of risk for WSW and MSM overall and within subgroups (e.g., heterosexual-identified WSW, Black MSM). This area of research is often hindered by the multiple ways in which MSM and WSW groups can be defined and the vast heterogeneity of people who fall within these categories. Further, because of the origins of WSW/MSM-terminology in HIV/AIDS research, there is a gendered imbalance in allocation of research funding toward MSM over WSW. Future research should address the limitations of this categorization system in understanding mental health by including multiple measures of sexuality to create a fine-grained understanding of which experiences of WSW/MSM transfer risk and by addressing the paucity of research on WSW and their mental health.
Effect of Pain Management Electronic Order Sets on Opioid Use in Adult Rib Fracture Patients
Authors: Hughes Andrea M. , Baumhover Lisa A. , Fuchsen Elizabeth A. , Spilman Sarah K. 
Published: July 2020

Background:
Inpatient pain management order sets are an important and necessary tool for standardizing and enhancing pain management for patients with traumatic injury. The purpose of this study was to assess the impact of revised inpatient pain management electronic order sets on opioid usage for patients with significant chest wall trauma.

Methods:
A retrospective pre-post study was conducted for adult patients with 3 or more rib fractures admitted to the hospital at a Level 1 trauma center. Two periods were compared: 1 year prior to the order set changes and the period immediately after the revisions were implemented. Differences between medians were assessed using Kruskal–Wallis test by ranks, and differences between nominal variables were assessed with χ2 test.

Results:
Twenty-five patients were analyzed for each period. There was no significant change between periods in the total amount of opioid received per day. There was a significant reduction in intravenous (IV) opioid use on the general inpatient floor (61% vs. 24%, p = .01), as well as in the percentage of patients who received IV opioid within 24 hr of discharge (40% vs. 4%, p = .002).

Conclusion:
Revised inpatient pain management order sets did not reduce overall opioid usage in a population of patients with 3 or more rib fractures. However, significant improvements were noted in decreased IV opioid usage on the general inpatient floors and within 24 hr of patient discharge from the hospital.
Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis
Authors: Xu Haitao , Qu Yiming 
Published: July 2020

Abstract

Background:
The present study was performed to statistically explore the effect of anthrax toxin receptor 2 (ANTXR2) polymorphism rs4333130 on individual susceptibility to ankylosing spondylitis (AS) using the method of meta-analysis.

Methods:
All of the eligible reports were retrieved from well-known electronic databases. The strength of the association between ANTXR2 polymorphism rs4333130 and the susceptibility to AS was evaluated using pooled odds ratios (ORs) with 95% confidence intervals (95% CIs). In addition, subgroup analysis was also performed on the basis of ethnicity to further explore specific correlation between our studied polymorphism and the disease risk. Inter-study heterogeneity was detected with Q test, and P < .05 was considered statistically significant. Sensitivity analysis was implemented through removing each of eligible studies and then recalculating overall effects to test the reliability of final estimates. Publication bias among included studies was inspected with both Begg funnel plot and Egger regression test.

Results:
A total of 6 eligible papers were finally incorporated into the present meta-analysis. In total analysis, ANTXR2 polymorphism rs4333130 was significantly related to decreased risk of AS under CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T and TC versus TT contrasts (OR = 0.35, 95% CI = 0.20–0.64; OR = 0.81, 95% CI = 0.69–0.95; OR = 0.38, 95% CI = 0.21–0.68; OR = 0.89, 95% CI = 0.84–0.95; OR = 0.84, 95% CI = 0.72–0.99). Moreover, a similar effect was also observed in Asian and Caucasian subgroups under corresponding genetic models after stratification analysis based on ethnicity.

Conclusion:

ANTXR2 polymorphism rs4333130 may function as a protective factor against AS incidence.
The inferior parathyroid glands preserved in site recover faster than the superior parathyroid glands preserved in site after thyroid surgery for carcinoma
Authors: Wang Bin , Zhu Chun-Rong , Liu Hong , Yao Xin-Min , Wu Jian 
Published: July 2020

Abstract
Due to the great difficulty in being preserved in site for the variable positions, the inferior parathyroid glands were advised to being routinely autotransplanted to prevent permanent hypoparathyroidism. The aim of this study was to compare the performance in the function of the superior parathyroid glands preserved in site with that of the inferior parathyroid glands preserved in site.
We conducted a retrospective study including patients who underwent thyroid surgery for papillary thyroid carcinoma at our department between January 2014 and June 2018. According to the number and original position of the autoplastic parathyroid gland(s), patients were divided into group 1 (1 superior parathyroid gland), group 2 (1 inferior parathyroid glands), group 3 (1 superior parathyroid gland and 1 inferior parathyroid gland) and group 4 (2 inferior parathyroid glands). The postoperative complications and serum parathyroid hormone and calcium were analyzed.
A total of 368 patients were included in the study, among them 27, 243, 40, and 58 patients were divided into group 1, group 2, group 3, and group 4, respectively. Compared with those in group 2, the serum parathyroid hormones were higher at 1 week (2.98 ± 1.52 vs 2.42 ± 0.89, P = .049) and 2 weeks (3.49 ± 1.42 vs 2.8 ± 0.81, P = .019) postoperatively in group 1. There was also significantly different in the serum parathyroid hormone at 2 weeks postoperatively between group 3 and group 4 (2.95 ± 0.98 vs 2.58 ± 0.82, P = .047).
The inferior parathyroid glands preserved in site recover faster than the superior parathyroid glands preserved in site.
Effectiveness and safety of indirect moxibustion for the treatment of allergic rhinitis
Authors: Yuan Ting , Fu Yong , Xiong Jun , Zhang Haifeng , Yang Jun , Wang Xue , Fan Hao , Jiang Yunfeng , Zhou Xiaohong , Liao Kai , Xu Lingling 
Published: July 2020

Abstract

Background:
Allergic rhinitis (AR) is a common allergic disorder worldwide. Western medicine is not optimistic about the therapeutic effect of this disease. However, moxibustion can enhance vital energy or immunity through a great number of clinical trials. Thus, the aim of this systematic review and meta-analysis is to systematically evaluate the effectiveness and safety of indirect moxibustion for treating AR.

Methods:
We will conduct a comprehensive literature search in Medline, PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure Database, WanFang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database from inception to August 2020 without any language restriction. In addition, we will retrieve the unpublished studies and the references of initially included literature manually. Reviewers will identify studies, extract data, and assess the quality independently. The outcomes of interest include: total effective rate, total nasal symptom score, total non-nasal symptom score, rhinitis quality of life questionnaire, visual analog scale, laboratory indicators (i.e., serum levels of IgE, IgA, or IgG), and adverse events. Randomized clinical trials will be collected, methodological quality will be evaluated using the Cochrane risk-of-bias assessment tool, and the level of evidence will be rated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Meta-analysis will be performed using RevMan 5.3.0 software. The heterogeneity test will be conducted between the studies, and P < .1 and I2 > 50% are the thresholds for the tests. We will utilize the fixed effects model or the random effects model according to the size of heterogeneity.

Results:
Because the review is ongoing, no results can be reported.

Conclusions:
The results of this review will provide reliable evidence for effectiveness and safety of indirect moxibustion for treating AR.

Ethics and dissemination:
Ethical approval is not required for this study. This systematic review and meta-analysis will be disseminated online and on paper to help guide clinicians.

PROSPERO Registration number:
CRD42019140944.
The effectiveness and harms of bortezomib in combination with chemotherapy for mantle cell lymphoma
Authors: Wang Xiaoxia , Li Wen , Wang Xin , Liu Xiaoli , Feng Cuijuan , Li Yihan , Li Jing 
Published: July 2020

Abstract

Background:
Chemotherapy with or without consolidation followed by autologous hematopoietic stem cell transplantation is the first-line treatment for mantle cell lymphoma. However, the effectiveness and safety of bortezomib-based chemotherapy for patients with mantle cell lymphoma is still uncertain.

Methods:
In this systematic review, the electronic databases of Cochrane Central Register of Controlled Trials, EMBASE, and PUBMED will be searched from inception to May 1, 2020. Randomized controlled trials that assessed the effectiveness and safety of bortezomib in combination with chemotherapy for patients with mantle cell lymphoma will be included. The patient's important outcomes include overall survival, progression-free survival, overall response rate, quality of life, and serious adverse events (eg, grade III-IV peripheral neuropathy, neutropenia, and infection). All process of the study selection, data extraction, and methodology evaluation will be carried out by 2 authors independently. RevMan 5.3 software will be utilized for statistical analysis.

Results:
This study will provide a detailed summary of latest evidence related to the effectiveness and safety of bortezomib in combination with chemotherapy in overall survival, progression-free survival, overall response rate, quality of life, and serious adverse events for patients with mantle cell lymphoma

Conclusion:
The findings of this study may provide possible guidance for bortezomib in combination with chemotherapy for patients with mantle cell lymphoma.

Systematic review registration:
PROSPERO CRD 42020154938.