bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers of Inflammation and Glomerular Filtration Rate in Individuals with Recent-Onset Type 1 and Type 2 Diabetes
Authors: Maalmi Haifa , Herder Christian , Strassburger Klaus , Urner Sofia , Jandeleit-Dahm Karin , Zaharia Oana-Patricia , Karusheva Yanislava , Bongaerts Brenda Wilhelma Corinna , Rathmann Wolfgang , Burkart Volker , Szendroedi Julia , Roden Michael 
Published: September 2020

Abstract

Context
While inflammation has been associated with kidney function in long-standing diabetes, its possible association in newly diagnosed diabetes is unknown.

Objective
To investigate cross-sectional and prospective associations between biomarkers of inflammation and kidney function in recent-onset diabetes.

Methods
The study included individuals with type 1 and type 2 diabetes with known diabetes duration of &lt;1 year from the German Diabetes Study. Baseline serum concentrations of 74 biomarkers were measured using proximity extension assay technology and their associations with estimated glomerular filtration rate (eGFR) and kidney function decline over 5 years were tested using multiple linear and logistic regression analysis.

Results
The cross-sectional analysis included 165 individuals with type 1 diabetes and 291 with type 2 diabetes. Baseline eGFR was higher in type 1 compared with type 2 diabetes (102 ± 15 vs 90 ± 16 mL/min/1.73 m2; P &lt; 0.0001). After full adjustment for covariates and multiple testing, 7 biomarkers were associated with lower baseline eGFR in type 1 diabetes and 24 were associated with lower baseline eGFR in type 2 diabetes. Among these biomarkers, 6 biomarkers (CD5, CCL23, CST5, IL-10RB, PD-L1, TNFRSF9) were inversely associated with eGFR in both diabetes types. The prospective analysis did not detect associations between inflammatory biomarkers and kidney function decline. No evidence of an interaction between diabetes type and inflammatory biomarkers was found.

Conclusion
Several biomarkers of inflammation associate with lower baseline eGFR in recent-onset type 1 and type 2 diabetes, but do not associate with kidney function loss during the first 5 years after the diagnosis of diabetes.
Approach to Managing a Postmenopausal Patient
Authors: Santen Richard J , Heitjan Daniel F , Gompel Anne , Lumsden Mary Ann , Pinkerton JoAnn V , Davis Susan R , Stuenkel Cynthia A 
Published: September 2020

Abstract

Case and Principles of Management
The case of a symptomatic, postmenopausal woman is presented and a full discussion of the approach to her management is discussed. Pertinent guidelines and scientific evidence are emphasized as support for the recommendations.
Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years
Authors: Pöllänen Petra M , Ryhänen Samppa J , Toppari Jorma , Ilonen Jorma , Vähäsalo Paula , Veijola Riitta , Siljander Heli , Knip Mikael 
Published: September 2020

Abstract

Context
We set out to characterize the dynamics of islet autoantibodies over the first 15 years of life in children carrying genetic susceptibility to type 1 diabetes (T1D). We also assessed systematically the role of zinc transporter 8 autoantibodies (ZnT8A) in this context.

Design
HLA-predisposed children (N = 1006, 53.0% boys) recruited from the general population during 1994 to 1997 were observed from birth over a median time of 14.9 years (range, 1.9-15.5 years) for ZnT8A, islet cell (ICA), insulin (IAA), glutamate decarboxylase (GADA), and islet antigen-2 (IA-2A) antibodies, and for T1D.

Results
By age 15.5 years, 35 (3.5%) children had progressed to T1D. Islet autoimmunity developed in 275 (27.3%) children at a median age of 7.4 years (range, 0.3-15.1 years). The ICA seroconversion rate increased toward puberty, but the biochemically defined autoantibodies peaked at a young age. Before age 2 years, ZnT8A and IAA appeared commonly as the first autoantibody, but in the preschool years IA-2A– and especially GADA-initiated autoimmunity increased. Thereafter, GADA-positive seroconversions continued to appear steadily until ages 10 to 15 years. Inverse IAA seroconversions occurred frequently (49.3% turned negative) and marked a prolonged delay from seroconversion to diagnosis compared to persistent IAA (8.2 vs 3.4 years; P = .01).

Conclusions
In HLA-predisposed children, the primary autoantibody is characteristic of age and might reflect the events driving the disease process toward clinical T1D. Autoantibody persistence affects the risk of T1D. These findings provide a framework for identifying disease subpopulations and for personalizing the efforts to predict and prevent T1D.
Persisting Muscle Dysfunction in Cushing’s Syndrome Despite Biochemical Remission
Authors: Vogel Frederick , Braun Leah T , Rubinstein German , Zopp Stephanie , Künzel Heike , Strasding Finn , Albani Adriana , Riester Anna , Schmidmaier Ralf , Bidlingmaier Martin , Quinkler Marcus , Deutschbein Timo , Beuschlein Felix , Reincke Martin 
Published: September 2020

Abstract

Context
Glucocorticoid-induced myopathy is a characteristic symptom of endogenous Cushing’s syndrome (CS). Its long-term outcome is largely unknown.

Objective
To evaluate long-term muscle function following the remission of endogenous CS.

Study Design
Observational longitudinal cohort study.

Setting
Tertiary care hospitals and a specialized outpatient clinic.

Patients
As part of the prospective multicenter German Cushing’s Registry, we assessed muscle strength in patients with overt endogenous CS. We studied the patients at the time of diagnosis (n = 88), after 6 months (n = 69), and thereafter annually, following surgical remission over a period of up to 4 years (1 year: n = 55; 2 years: n = 34; 3 years: n = 29; 4 years: n = 22). Muscle function was evaluated by hand grip strength and by chair rising test.

Results
Grip strength was decreased to 83% of normal controls (100%) at the time of diagnosis. It further decreased to 71% after 6 months in remission (P ≤ 0.001) and showed no improvement during further follow-up compared with baseline. Chair rising test performance improved initially (8 seconds at baseline vs 7 seconds after 6 months, P = 0.004) but remained at this reduced level thereafter (7 seconds after 3 years vs 5 seconds in controls, P = 0.038). In multivariate analysis, we identified, as predictors for long-term muscle dysfunction, age, waist-to-hip ratio, and hemoglobin A1c at baseline. Furthermore, muscle strength during follow-up was strongly correlated with quality of life.

Conclusion
This study shows that CS-associated myopathy does not spontaneously resolve during remission. This calls for action to identify effective interventions to improve muscle dysfunction in this setting.
The effects of dietary seaweed inclusion on growth performance of broiler chickens: a systematic review and meta-analysis
Authors: Andri Faizal , Dono Nanung Danar , Sasongko Heru , Zuprizal Zuprizal 
Published: September 2020

Background: There has been great interest in the use of seaweed as a functional feed ingredient for poultry in the last decade. This study aimed to assess the effects of dietary seaweed inclusion on growth performance of broiler chickens by using a systematic review and meta-analysis approach. Methods: A systematic search of published research articles related to seaweed, broiler chickens, and growth performance was conducted using three online databases (Scopus, PubMed, and SciELO). Mean values, standard deviation, and sample size were extracted from each eligible study. The estimated effect size was then quantified using Hedges’ g with a 95% confidence interval (CI). Data were pooled using a fixed-effect model due to the absence of heterogeneity after being pre-checked using the I2 statistic. Results: A total of six studies (nine comparisons) involving 2,257 broiler chickens were accommodated in this study. The seaweed type consisted of seaweed blend, Laminaria japonica, Undaria pinnatifida, Hizikia fusiformis, and Ulva lactuca. The inclusion dose ranged from 2 to 30 g/kg, while the intervention duration ranged from 21 to 42 days. No substantial heterogeneity among studies (I2 = 0.00%) was found for feed intake, body weight gain, and feed conversion ratio. Dietary seaweed had no significant effect on feed intake (Hedges’ g = 0.19; 95% CI = -0.22 to 0.60; P = 0.280). However, broiler chickens fed dietary seaweed had superior body weight gain (Hedges’ g = 0.64; 95% CI = 0.22 to 1.06; P = 0.000) and preferable feed conversion ratio (Hedges’ g = -0.53; 95% CI = -0.95 to -0.11; P = 0.004). Conclusions: The current investigation highlights that dietary seaweed had growth-promoting potency for broiler chickens. However, more research on this issue is still required to build more comprehensive evidence.
Inclusão digital: resultados de um curso de informática para idosos
Authors: Raphael Bokehi José , Almeida Rocha Gian Vitor , Vilas-Bôas Hacker Alvarenga Maria Carmen 
Published: September 2020

A inclusão digital de idosos ainda representa um desafio no Brasil. O Projeto Incluir surgiu em 2006, sob o financiamento da Financiadora de Estudos e Projetos (FINEP), visando atender ao Pré-Universitário Popular da Escola de Engenharia da UFF. Em 2007, ampliou sua atuação ao público idoso através da parceria com o do programa de extensão Espaço Avançado da Terceira Idade, da Escola de Serviço Social da UFF, um dos primeiros programas institucionais a focalizar questões de envelhecimento e a atender à terceira idade em Niterói. O papel do Projeto Incluir é prover o acesso à tecnologia a uma parcela da população que, por motivos culturais ou socioeconômicos, se vê à parte do mundo informatizado. Este trabalho relata os resultados obtidos por este projeto no período de 2010 a 2018. Para tanto foi efetuada uma busca documental nos relatórios anuais do projeto, bem como nas avaliações dos bolsistas e alunos que dele participaram neste mesmo período. Foram atendidos 384 idosos, em turmas de nível inicial e avançado. O projeto contou com 20 bolsistas de extensão, 5 discentes voluntários e 2 professores ao longo de seu funcionamento. As avaliações dos alunos mostram satisfação com o curso e incorporação de atividades ligadas à informática em suas atividades de rotina. Dessa forma, conclui-se que o projeto vem contribuindo para ampliar a utilização das ferramentas de informática no cotidiano dos alunos, favorecendo a adoção de novas formas de inserção social e o uso de ferramentas de interesse na sua rotina.
High-speed reconfigurable free-space optical interconnects with carrierless-amplitude-phase modulation and filter-enhanced spatial modulation
Authors: Wang Ke 
Published: September 2020

Optical technologies have been widely studied to satisfy the interconnect demand in high-performance computers and data centers, and free-space optical interconnects have been investigated for flexible card-to-card applications. To increase the interconnect speed and range, in this Letter we propose a reconfigurable free-space optical interconnect with 16-carrierless-amplitude-phase (16-CAP) symbol modulation and filter-enhanced spatial modulation (FE-SM). The 16-CAP increases the interconnect speed in the symbol domain, and the FE-SM scheme increases the speed in the spatial domain, even under highly correlated optical interconnect channels. A 50 Gb/s reconfigurable optical interconnect is experimentally demonstrated. The results show that the impact of FE-SM on the bit error rate (BER) is negligible, while the speed is significantly improved. Compared with the conventional SM scheme, the BER is improved by over one order of magnitude. The proposed scheme is also capable of extending the interconnect range. The results show that over 70% range extension and 50% speed increase can be achieved simultaneously. The proposed scheme with a 16-CAP and FE-SM provides a promising solution in free-space optical interconnects.
Pengaruh Penggunaan Strategi Pembelajaran Inquiry Terhadap Kecerdasan Naturalis Anak Usia Dini di Kabupaten Majalengka
Authors: Ulfah Maulidya , Khoerunnisa Yurida 
Published: September 2020

Abstract Inquiry learning strategy is a series of learning activities that involve the ability of students to the maximum in searching, investigating and solving a problem. While naturalist intelligence is the intelligence that one has in recognizing, loving, and preserving the flora, fauna, and the surrounding environment. This study aims to know the application of inquiry strategy strategy in early childhood, to know the naturalist intelligence of early child, to know how influence the use of inquiry learning strategy to the naturalist intelligence of early child. This research uses quantitative research approach with experimental design and pre-test and post test group type. The results of research that has been done by the researcher can be concluded that the use of inquiry learning strategy influence the early child naturalist intelligence
Strategi pembelajaran inquiry merupakan suatu rangkaian kegiatan pembelajaran yang melibatkan kemampuan anak didik secara maksimal dalam mencari, menyelidiki dan memecahan sebuah masalah. Sedangkan kecerdasan naturalis adalah kecerdasan yang dimiliki seseorang dalam mengenali, mencintai, dan menjaga flora, fauna, dan lingkungan sekitarnya. Penelitian ini bertujuan untuk mengetahui penerapan strategi pembelajaran inquiry pada anak usia dini, mengetahui kecerdasan naturalis anak usia dini, serta mengetahui sejauhmana pengaruh penggunaan strategi pembelajaran inquiry terhadap kecerdasan naturalis anak usia dini. Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan jenis eksperimen dan desain penelitian pre experimental design dengan jenis pre-test and post test group. Hasil penelitian yang telah dilakukan oleh peneliti, kecerdasan naturalis anak usia dini pada kelompok B di TKIT Al-Farisi Majalengka setelah diberikan treatment (strategi pembelajaran inquiry) lebih baik daripada sebelum diberikan treatment. Sehingga dapat disimpulkan bahwa penggunaan strategi pembelajaran inquiry berpengaruh terhadap kecerdasan naturalis anak usia dini
Keywords: Inquiry learning strategy, naturalis intellegence, early childhood
Calculation of Electron Swarm Parameters in Tetrafluoromethane
Authors: Salih Idris H. , Othman Mohammad M. , Taha Sherzad A. 
Published: September 2020

The electron swarm parameters and electron energy distribution function (EEDF) are necessary, especially onunderstanding quantitatively plasma phenomena and ionized gases. The EEDF and electron swarm parameters including the reduce effective ionization coefficient (α-η)/N (α and η are the ionization and attachment coefficient, respectively), electron drift velocity, electron mean energy, characteristic energy, density normalized longitudinal diffusion coefficient, and density normalized electron mobility in tetrafluoromethane (CF4) which was analyzed and calculated using the two-term approximation of the Boltzmann equation method at room temperature, over a range of the reduced electric field strength (E/N) between 0.1 and 1000 Td(1Td=10-17 V.cm2), where E is the electric field and N is the gas density of the gas. The calculations required cross-sections of the electron beam, thus published momentum transfer, vibration, electronic excitation, ionization, and attachment cross-sections for CF4 were used, the results of the Boltzmann equation in a good agreement with experimental and theoretical values over the entire range of E/N. In all cases, negative differential conductivity regions were found. It is found that the calculated EEDF closes to Maxwellian distribution and decreases sharply at low E/N. The low energy part of EEDF flats and the high-energy tail of EEDF increases with increase E/N. The EEDF found to be non-Maxwellian when the E/N> 10Td, havingenergy variations which reflect electron/molecule energy exchange processes. In addition, limiting field strength (E/N)limit has been calculated from the plots of (α-η)/N, for which the ionization exactlybalances the electron attachment, which is valid for the analysis of insulation characteristics and application to power equipment.
Interaction of Fear Conditioning with Eyeblink Conditioning Supports the Sensory Gating Hypothesis of the Amygdala in Men
Authors: Inoue Lana , Ernst Thomas Michael , Ferber Inda Inat , Merz Christian Josef , Timmann Dagmar , Batsikadze Giorgi 
Published: September 2020

AbstractInhibition of the amygdala slows down acquisition of conditioned eyeblink responses (CRs). Based on the two-stage or two-factor theory of aversive conditioning, amygdala-dependent conditioned fear is a necessary prerequisite to acquire eyeblink CRs but is no longer needed after eyeblink CRs are attained. According to the sensory gating hypothesis of the amygdala, on the other hand, the amygdala modulates the salience of unconditioned stimuli (USs) and conditioned stimuli (CSs) in eyeblink conditioning. We tested these two opposing assumptions in five groups of 20 young and healthy men. On day 1, three groups underwent fear acquisition training followed by acquisition of eyeblink CRs. On the next day (day 2), extinction was tested. In group 1, fear and eyeblink extinction trials overlapped; in group 2, fear and eyeblink extinction trials alternated; and in group 3, fear extinction trials were followed by eyeblink extinction trials. Groups 4 and 5 were control conditions testing fear and eyeblink conditioning only. Preceding fear acquisition training facilitated acquisition of conditioned eyeblinks. Concomitant fear extinction impeded extinction of eyeblink CRs, which was accompanied by increased autonomic responses. Fear extinction, however, was not significantly altered by concomitant eyeblink extinction. Recall of fear CRs on day 2 was facilitated in group 1, suggesting additive response summation. Findings are difficult to explain with the two-stage theory of aversive conditioning, which predicts the suppression of conditioned fear once conditioned eyeblinks are acquired. Facilitated acquisition and impeded extinction of eyeblink CRs, however, are in accordance with the sensory-gating hypothesis of the amygdala.
Prevalence of basal ganglia and carotid artery calcifications in patients with permanent hypoparathyroidism after total thyroidectomy
Authors: Lorente-Poch Leyre , Rifà-Terricabras Sílvia , Sancho Juan José , Torselli-Valladares Danilo , González-Ortiz Sofia , Sitges-Serra Antonio 
Published: September 2020

Objective:
Permanent hypoparathyroidism is an uncommon disease resulting most frequently from neck surgery. It has been associated with visceral calcifications but few studies have specifically this in patients with post-surgical hypoparathyroidism. The aim of the present study was to assess the prevalence of basal ganglia and carotid artery calcifications in patients with long-term post-thyroidectomy hypoparathyroidism compared with a control population.

Design:
Case–control study.

Methods:
A cross-sectional review comparing 29 consecutive patients with permanent postoperative hypoparathyroidism followed-up in a tertiary reference unit for Endocrine Surgery with a contemporary control group of 501 patients who had an emergency brain CT scan. Clinical variables and prevalence of basal ganglia and carotid artery calcifications were recorded.

Results:
From a cohort of 46 patients diagnosed with permanent hypoparathyroidism, 29 were included in the study. The mean duration of disease was 9.2 ± 7 years. Age, diabetes, hypertension, smoking and dyslipidemia were similarly distributed in case and control groups. The prevalence of carotid artery and basal ganglia calcifications was 4 and 20 times more frequent in patients with permanent hypoparathyroidism, respectively. After propensity score matching of the 28 the female patients, 68 controls were matched for age and presence of cardiovascular factors. Cases showed a four-fold prevalence of basal ganglia calcifications, whereas that of carotid calcifications was similar between cases and controls.

Conclusion:
A high prevalence of basal ganglia calcifications was observed in patients with post-surgical permanent hypoparathyroidism. It remains unclear whether carotid artery calcification may also be increased.
El papel actual de la educación
Authors: Sánchez Amaya Tomás 
Published: September 2020

La reflexión acerca del papel que las sociedades modernas han asignado a la educación, como eje articuladorde los diferentes sistemas y campos que la componen, como medio para la configuración de una cultura más humanizante y humanizadora, como instrumento que se oriente hacia el reconocimiento de la dignidad de las personas y de los pueblos, ha cobrado hoy capital y relevante importancia. Se trata pues, de pensar el redireccionamiento del proceso educativo, su orientación hacia la promoción integral del ser humano en la totalidad de sus dimensiones y posibilidades, con miras en la construcción de una sociedad más justa, más equitativa, más humana, procurando el desarrollo armónico de las diversas facultades humanas de un modo integral. Recobrar la dimensión holistica de la educación de manera que la adquisición de conocimientos, ciencias, técnicas, habilidades y destrezas esté siempre acompañada por la práctica de actitudes morales, éticas y axiológicas, necesarias para que las personas sobrevivan, mejoren su calidad de vida e impregnen de sentido su propia existencia.
RESULTS OF IN VITRO ANDROGENESIS UNDER INCREASING SALINITY CONDITIONS FOR THREE MOROCCAN SPRING BARLEY VARIETIES (HORDEUM VULGARE L.)
Authors: Hentour Samira , EL GOUMI Younes , OUBAIDOU Rabouan , EL AANACHI Soukaina , LAMSAOURI Ouafa , ESSAYAGH Sanah , HOUMAIRI Hafsa , FAKIRI Malika 
Published: September 2020

In vitro androgenesis process under salt pressure is recognized as being a valuable method for quick production of salt stress tolerant doubled haploid lines, enabling yield improvement of plants cultivated in dry climates. This study aimed to investigate the effect of salt stress on in vitro androgenetic regeneration, and the production of salt tolerant barley doubled haploid lines. Moroccan barley varieties, Arig, Asni and Tamelalt were used as RS0, and after one round of selfing (RS1) or two (RS2). These successive generations made possible to verify genetic stability or possible accidental heterozygosity, and to obtain plants presumably more tolerant to salinity. After culture of 11,340 anthers on induction medium, 2,270 calluses or embryos were generated. According to the induction rate of these formations, the three generations of each variety were not significantly different, pointing out the genetic stability after two selfings. Tamelalt and Arig had similar in vitro response, while for Asni, the three generations behaviour differed from the previous ones and constitute a statistically separate group. After transfer of the formations on regeneration medium either salt free, as control, or supplemented by increasing concentrations of NaCl, ranging from 2.5 to 13 g.L-1, 170 regenerants were produced. Asni (RS1) showed to be the most salt tolerant, bearing the maximal NaCl concentration of 12 g.L-1, but the single regenerated plant obtained was albino, as most of the regenerated plants from any genotype and generation. However, RS1 and RS2 generations of Asni regenerated one green plant each, with NaCl concentration of 5 g.L-1, resulting in two new Asni doubled haploid fertile lines.