bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upconversion Nanoparticles–Based Multiplex Protein Activation to Neuron Ablation for Locomotion Regulation
Authors: Zhang Yan , Zhang Wanmei , Zeng Kanghua , Ao Yanxiao , Wang Mengdie , Yu Zhongzheng , Qi Fukang , Yu Weiwei , Mao Heng , Tao Louis , Zhang Cuntai , Tan Timothy Thatt Yang , Yang Xiangliang , Pu Kanyi , Gao Shangbang 
Published: January 2020

AbstractThe optogenetic neuron ablation approach enables noninvasive remote decoding of specific neuron function within a complex living organism in high spatiotemporal resolution. However, it suffers from shallow tissue penetration of visible light with low ablation efficiency. This study reports a upconversion nanoparticle (UCNP)–based multiplex proteins activation tool to ablate deep‐tissue neurons for locomotion modulation. By optimizing the dopant contents and nanoarchitecure, over 300‐fold enhancement of blue (450–470 nm) and red (590–610 nm) emissions from UCNPs is achieved upon 808 nm irradiation. Such emissions simultaneously activate mini singlet oxygen generator and Chrimson, leading to boosted near infrared (NIR) light–induced neuronal ablation efficiency due to the synergism between singlet oxygen generation and intracellular Ca2+ elevation. The loss of neurons severely inhibits reverse locomotion, revealing the instructive role of neurons in controlling motor activity. The deep penetrance NIR light makes the current system feasible for in vivo deep‐tissue neuron elimination. The results not only provide a rapidly adoptable platform to efficient photoablate single‐ and multiple‐cells, but also define the neural circuits underlying behavior, with potential for development of remote therapy in diseases.
Robust Biological Fibers Based on Widely Available Proteins: Facile Fabrication and Suturing Application
Authors: Zhang Jinrui , Sun Jing , Li Bo , Yang Chenjing , Shen Jianlei , Wang Nan , Gu Rui , Wang Daguang , Chen Dong , Hu Honggang , Fan Chunhai , Zhang Hongjie , Liu Kai 
Published: January 2020

AbstractLightweight and mechanically strong protein fibers are promising for many technical applications. Despite the widespread investigation of biological fibers based on spider silk and silkworm proteins, it remains a challenge to develop low‐cost proteins and convenient spinning technology for the fabrication of robust biological fibers. Since there are plenty of widely available proteins in nature, it is meaningful to investigate the preparation of fibers by the proteins and explore their biomedical applications. Here, a facile microfluidic strategy is developed for the scalable construction of biological fibers via a series of easily accessible spherical and linear proteins including chicken egg, quail egg, goose egg, bovine serum albumin, milk, and collagen. It is found that the crosslinking effect in microfluidic chips and double‐drawn treatment after spinning are crucial for the formation of fibers. Thus, high tensile strength and toughness are realized in the fibers, which are comparable or even higher than that of many recombinant spider silks or regenerated silkworm fibers. Moreover, the suturing applications in rat and minipig models are realized by employing the mechanically strong fibers. Therefore, this work opens a new direction for the production of biological fibers from natural sources.
Mortality of Endangered Juvenile Lost River Suckers Associated with Cyanobacteria Blooms in Mesocosms in Upper Klamath Lake, Oregon
Authors: Burdick Summer M. , Hereford Danielle M. , Conway Carla M. , Banet Nathan V. , Powers Rachel , Martin Barbara A. , Elliott Diane G. 
Published: January 2020

AbstractUnsustainably high mortality within the first 2 years of life prevents endangered Lost River Suckers Deltistes luxatus in Upper Klamath Lake, Oregon, from recruiting to spawning populations. Massive blooms of the cyanobacterium Aphanizomenon flos‐aquae and their subsequent death and decay in the lake (bloom‐crashes) are associated with high pH, low percent oxygen saturation, high total ammonia concentrations, and spikes in the cyanotoxin microcystin. Poor water quality within the lake is considered the most likely cause of juvenile sucker mortality, but mechanisms causing the high mortality are not known. We introduced PIT‐tagged age‐1 Lost River suckers into three continuously monitored mesocosms in Upper Klamath Lake to determine the timing of juvenile sucker mortality relative to pH, temperature, and dissolved oxygen. Mortality was inferred from a lack of movement detected on remote PIT tag detection equipment within each mesocosm. Mortality was compared among mesocosms and an indoor tank‐held control group. We fitted time‐varying Cox hazard models to test hypotheses about short‐term and chronic effects of single and co‐occurring water quality parameters on the daily hazard rate. Presumed healthy or moribund fish that were collected pre‐season, mid‐season, or at the end of the study were examined macroscopically and histologically to generate inferences about the causes of mortality. Models did not indicate a plausible association between water quality variables and mortality. Hypoxia preceded periods of higher mortality at two of three sites but did not co‐occur with mortality. Hatchery‐reared Lost River Suckers confined to mesocosms may not represent the behavior of wild fish, and it is unclear whether the same factors affect the mortality of wild age‐0 suckers.
Place and language: Links between speech, region, and connection to place
Authors: Reed Paul E. 
Published: January 2020

AbstractThe relationship to place and language has been central to linguistic research since the beginning. Several distinctive eras of investigation into place and language have taken place, from focusing on relatively nonmobile elderly speakers to deep investigations of how different speakers relate to a particular place. Place impacts language in a variety of ways, from large differences between national varieties to ecological and social distinctions in varieties associated with a small local area or neighborhood. Further, place interacts with other social factors and contributes to linguistic variation in an additive (or perhaps even multiplicative) fashion. As the investigation into the impact of place has developed and evolved, researchers have noted that it is not merely place itself that is the most important, rather the speaker'srelationshipto place that is perhaps the most crucial aspect. In fact, a speaker with a close connection to place might use features that are associated with a particular place even if those features are stigmatized, because those features represent the speaker's connection to place. Without consideration of how a speaker orients—whether toward or away—any investigation into place or regionality and language will be incomplete.This article is categorized under:Linguistics > Linguistic TheoryPsychology > Language
Organelle size scaling over embryonic development
Authors: Wesley Chase C. , Mishra Sampada , Levy Daniel L. 
Published: January 2020

AbstractCell division without growth results in progressive cell size reductions during early embryonic development. How do the sizes of intracellular structures and organelles scale with cell size and what are the functional implications of such scaling relationships? Model organisms, in particular Caenorhabditis elegans worms, Drosophila melanogaster flies, Xenopus laevis frogs, and Mus musculus mice, have provided insights into developmental size scaling of the nucleus, mitotic spindle, and chromosomes. Nuclear size is regulated by nucleocytoplasmic transport, nuclear envelope proteins, and the cytoskeleton. Regulators of microtubule dynamics and chromatin compaction modulate spindle and mitotic chromosome size scaling, respectively. Developmental scaling relationships for membrane‐bound organelles, like the endoplasmic reticulum, Golgi, mitochondria, and lysosomes, have been less studied, although new imaging approaches promise to rectify this deficiency. While models that invoke limiting components and dynamic regulation of assembly and disassembly can account for some size scaling relationships in early embryos, it will be exciting to investigate the contribution of newer concepts in cell biology such as phase separation and interorganellar contacts. With a growing understanding of the underlying mechanisms of organelle size scaling, future studies promise to uncover the significance of proper scaling for cell function and embryonic development, as well as how aberrant scaling contributes to disease.This article is categorized under:
Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing
Early Embryonic Development > Fertilization to Gastrulation
Comparative Development and Evolution > Model Systems
Langsam progrediente Gelenkzerstörung bei einem älteren Mann als Ausdruck einer Hydroxylapatiterkrankung. Fallbericht und Literaturübersicht
Authors: Zipfel N. , Dießel L. , Delank K.-S. , Keyßer G. , Schäfer C. 
Published: January 2020

ZusammenfassungWir berichten über einen 75-jährigen männlichen Patienten mit seit 10 Jahren bestehenden Arthralgien der großen Gelenke. Klinisch fand sich eine Bursitis des rechten Ellenbogengelenkes. Laborchemisch zeigte sich eine Entzündungskonstellation, und röntgenologisch ergaben sich erosive Gelenkdestruktionen. Es erfolgte eine operative Bursektomie. Histologisch konnten in der Alizarinrotfärbung Hydroxylapatitkristalle nachgewiesen und die Diagnose einer Kristallarthropathie gestellt werden. Die Diagnostik ist schwierig, da die Kristalle nur elektronenmikroskopisch oder mittels Spezialfärbungen nachgewiesen werden können.
In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials
Authors: Overbeck N. , Nagvajara G. M. , Ferzoco S. , May B. C. H. , Beierschmitt A. , Qi S. 
Published: January 2020

Abstract
Purpose
Two innovative reinforced biologic materials were studied in a non-human primate hernia repair model. The test articles, which combine layers of ovine decellularized extracellular matrix with minimal amounts of synthetic polymer, were evaluated for their biologic performance as measured by inflammatory response, healing kinetics, integration, and remodeling into functional host tissue. For comparison, seven clinically used biologic and synthetic meshes were also studied.

Methods
Animals were implanted with test articles in surgically created full-thickness midline abdominal wall defects, and evaluated macroscopically and histologically at 4, 12, and 24 weeks.

Results
Macroscopically, biologics resorbed and remodeled into naturally appearing tissue; the reinforced biologics appeared similar, but remodeled earlier and were less prone to stretch. Synthetics developed a layer of reactive tissue above and separate from the contracted mesh structure. At early time points, the collagen networks of biologics and reinforced biologics were infiltrated by host cells primarily as a peripheral layer on the biologics. As early as 12 weeks, the collagen networks associated with the reinforced biologics remodeled into organized host collagen. By 24 weeks, both reinforced biologics and biologics had low levels of inflammation. In contrast, a foreign body response persisted at 24 weeks with the synthetics, which had developed less organized collagen, separate in space from the actual mesh.

Conclusions
The current study shows a favorable response to reinforced biologics, which were associated with an initial inflammatory response, resolving by later time points, followed by active remodeling, and the formation of new morphologically functional collagen.
Identification of children with chronic kidney disease through school urinary screening using urinary protein/creatinine ratio measurement: an observational study
Authors: Kajiwara Nobuyuki , Hayashi Kazuyuki , Fujiwara Makoto , Nakayama Hirofumi , Ozaki Yoshikazu 
Published: January 2020

AbstractBackgroundSchool urinary screening has been performed in Japan.MethodsIkeda City and Toyono Town introduced, in 2012 and 2013, urinary protein/creatinine (Cr) ratio measurement into the urine-screening protocols designed for students aged between 4 and 15 years. For each student whose urinary protein/Cr ratio was ≥ 0.15 g/gCr (positive case), an appointment was made with a specialist at Ikeda City Hospital. The results of these screening urinalyses conducted through 2018 are summarized.Results14,606 junior high and elementary school students aged between 6 and 15 years were included. On average, they underwent 4.16 screening tests. 77 positive cases were detected, and seven students were diagnosed with high-risk chronic kidney disease (CKD). Of these, four underwent renal biopsy, and two, one, and one were diagnosed with IgA nephropathy, MPGN, and FSGS, respectively. In three students, detection of CKD would have been difficult without urinary screening. Incident rates of high-risk CKD and IgA nephropathy are estimated as 11.5 and 3.3 cases/100,000 students/year. 78.0% of positive cases without high-risk CKD showed no urinary abnormality after one year. 2301 kindergarten students aged between 4 and 6 years received an average of 1.74 screening urinalyses; none was positive or high-risk CKD. The estimated cost of detecting one high-risk CKD student whose detection would have been difficult without this screening was 3,156,711 Japanese yen.ConclusionSchool urinary screening using the urinary protein/Cr ratio can efficiently refer to a specialist. It detects a few children with high-risk CKD early with spending high cost.
Natural and Anthropogenic Conditions of the Chemical Composition of Pit Lake Waters (Based on Example Pit Lakes from Central Europe)
Authors: Molenda Tadeusz , Kidawa Joanna 
Published: January 2020

自然因素和人为影响下矿坑湖水化学组分 (基于中欧矿坑湖案例)文章描述了矿坑湖水化学类型分类。虽然自然因素对水化学组分具有重要作用,但是人为影响也能引起水化学类型的很大差异。矿坑湖水的化学组成主要由矿坑内的岩石类型所决定。同时,次生的人为影响也会使水化学组分发生改变。利用多维聚类分析,将矿坑湖划分为三种水化学类型。矿坑湖水三种化学类型:重碳酸-镁-钙水型(HCO3 - Mg - Ca)、重碳酸盐-钙水型(HCO3 - Ca)和硫酸-钙水型(SO4 - Ca)。
Predicting the Willingness to Engage in Non-Consensual Forwarding of Sexts: The Role of Pornography and Instrumental Notions of Sex
Authors: van Oosten Johanna M. F. , Vandenbosch Laura 
Published: January 2020

AbstractAlthough non-consensual forwarding of sexts (NCFS) is an important type of online sexual harassment behavior, the predictors of this behavior are currently understudied. The present study aimed to fill this gap by investigating online pornography use as a predictor of adolescents’ and emerging adults’ willingness to engage in NCFS in different contexts (i.e., forwarding a sexually explicit picture of a dating partner, relationship partner, friend, stranger or ex-partner). Based on previous literature on the role of pornography in the prediction of sexual harassment, we hypothesized that this relationship would depend on individuals’ prior endorsement of sexual stereotypical attitudes (i.e., instrumental attitudes toward sex). We further investigated whether this would differ for adolescent and young adult males and females. We used data from a two-wave short-term (2 months between waves) longitudinal survey among 1947 participants (aged 13–25 years). Results from cross-lagged autoregressive latent SEM models showed that pornography use significantly predicted a higher willingness to forward sexts from a stranger, but mostly among adolescent boys (aged 13–17) with high levels of instrumental attitudes toward sex.
What recent primary studies tell us about ovarian teratomas in children: a scoping review
Authors: Łuczak Justyna , Bagłaj Maciej , Dryjański Piotr 
Published: January 2020

AbstractOur knowledge of ovarian teratomas in children is still far from complete, and much remains to be discovered. Here, we conduct a scoping review of the primary research related to ovarian teratomas in pediatric age. To our knowledge, there is no published synthesis of the literature surrounding ovarian teratomas in children using scoping review methodology. We identified 24 studies from 11 countries; 18 studies were retrospective, 3 were prospective, and 3 were experimental. There were 6 studies concerning mature teratomas, 5 concerning immature teratomas, and 13 that included both tumor types. Overall, 9 out of all the studies concerned more than 50 patients. We revealed 7 major branches of research within the topic of ovarian teratoma in pediatric population: recurrence rate/relapse and follow-up strategy, malignant potential, prognostic factors, use of sparing surgery, differences between the use of laparoscopy and laparotomy, use of chemotherapy, and additional examinations to test the character of the lesion (immature vs. mature). This scoping review has revealed a number of knowledge gaps in the evidence base for pediatric ovarian teratomas. Overall, this topic has not been extensively explored, and more research dedicated exclusively to this tumor and patient population is required.
Factors of variability in the accumulation of waste in a mountain region of southern Poland
Authors: Przydatek Grzegorz , Ciągło Klaudia 
Published: January 2020

AbstractThe analysis of change factors in waste management in the period from 2012 to 2015 in three municipalities in a mountainous region of southern Poland exhibited strong differentiation. This was recognised based on multiple indicators of waste accumulation. Such differences were investigated between two periods, which highlighted the effect of changes in waste management primarily resulting from Directive 2008/98/EC. These changes relate to the development of selective waste collection based on eight types of waste. On this basis, an increase was observed in the amount of waste collected in the communities. Particular attention was paid to the community with the highest number of tourists, the waste accumulation rate (452.74 kg per capita) and the cost per year. An increase in the number of tourists is an important factor in terms of waste accumulation, and other factors made it possible to recognise the direction of the changes taking place in waste management. In terms of changes in waste accumulation, the implementation of the European Union law into the national law in the field of waste management is a significant factor.
The Concept of Manas in Jaina Philosophy
Authors: Soni Jayandra 
Published: January 2020

AbstractThe first time Umāsvāti uses the word manas in his Tattvārtha-sūtra (TAS), the standard work for matters concerning Jaina philosophy, is when he lists the means of knowledge: mati, śruta, avadhi, manaḥ-paryāya and kevala (TAS 1, 9). These are the pramāṇas (TAS 1, 10). In TAS 1, 14 mati or sense perception is said to be caused by indriya and aninindriya; Pūjyapāda’s commentary says that anindriya, antaḥ-karaṇa and manas are synonyms. This obviously raises questions about the specific role and function of the manas/anindriya in mati, manaḥ-paryāya and śruta, and how these retain their exclusivity without reducing the function of any of them to another means of cognition. In the Sāṅkhya system manas is seen as both an organ of cognition (buddhīndriya) and an organ of action (karmendriya, SK 27). It is interesting for a better understanding of the role of manas in Jaina thought to compare some aspects of it with the Sāṅkhya system.
Hollywood studio filmmaking in the age of Netflix: a tale of two institutional logics
Authors: Hadida Allègre L. , Lampel Joseph , Walls W. David , Joshi Amit 
Published: January 2020

AbstractOnline streaming services are challenging long-standing decision-making processes in the traditional motion picture industry, thus placing Hollywood major studios at a crossroads. We use the institutional logics perspective to examine how both traditional studios and online streaming services make strategic decisions on which films to produce and how these films are to be distributed. We then apply scenario analysis to explore how their interaction will likely evolve. We argue that the key criteria that studio executives use to make production and distribution decisions are shaped by what we define as a commitment institutional logic: decision-making heuristics that focus their attention on theatrical release and box-office intakes. In contrast, online streaming services follow a convenience institutional logic, the product of advanced data analytics to increase subscriptions. In the convenience institutional logic, the need to drive online traffic by providing users with an extensive catalogue of movies guides film production and distribution decisions. Whereas the commitment logic aims for mass-market hits in cinemas, the convenience logic seeks to reach a wide range of subscribers at home with micro-segmented offerings. We compare the two logics, develop four scenarios of how the interaction between them may shape the film industry, and offer recommendations.
Species and thermal radiation on micropolar hydromagnetic dusty fluid flow across a paraboloid revolution
Authors: Gnaneswara Reddy M. , Ferdows M. 
Published: January 2020

AbstractHydromagnetic flow of energy and species transfer behaviour of micropolar dusty fluid across a paraboloid revolution has been investigated. Heat and mass transfer phenomena are inspected through radiation, joule heating and chemical reaction. The boundary layer equations are modelled and transformed to a system of ODE’S with the aid of similarity transformations and solved numerically by utilizing Runge–Kutta integration scheme. The graphical analysis has been emphasized for the fluid and dust phase velocity, angular velocity, energy and species fields to the influence of sundry dynamical flow quantities. In addition, friction factor, Nusselt number and Sherwood number are presented in plots and tables and discussed elaborately and nice validation is emphasized. The obtained numerical results are checked with the earlier published articles. The boundary layers of angular velocity, temperature and concentration distributions increase for escalating values of magnetic parameter. For escalating values of material parameter, velocity profile increases for both momentum velocity and dusty velocity and opposite trend is seen in angular velocity profile. Concentration and boundary layer thickness diminish for escalating values of kr. Local friction factor declines for boost up values of magnetic parameter and porosity permeability parameter. The rate of heat transfer decreases for increasing values of Eckert number and radiation parameter, and rate of mass transfer increases for increasing values of Schmidt number and chemical reaction parameter.
Experimenting with Law: Brecht on Copyright
Authors: Bellido Jose 
Published: January 2020

AbstractCan one reject copyright law and be a qualified observer of its dispositives? This question was taken up by Bertolt Brecht in an intriguing essay concerning the litigation surrounding the film adaptation ofThe Threepenny Opera(1928). Brecht here develops an experimental observation around the nature of film adaptation and cultural production in copyright. While an experimental approach to law was in itself a subversive gesture, the specific legal process enabled him to expose the paradoxical ways in which the copyright system worked.