bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal localization of aPseudoterranova decipienslarva in a Danish patient with suspected allergic rhinitis
Authors: Nordholm A. , Kurtzhals J.A.L. , Karami A.M. , Kania P.W. , Buchmann K. 
Published: September 2020

AbstractPseudoterranoviasis is a zoonotic disease caused by nematode larvae of species within the genusPseudoterranova(seal worm, cod worm). Most infections are gastrointestinal, oesophageal or pharyngeal, but here we report a nasal infection. A 33-year-old patient suffering from rhinitis for 1.5 years recovered a worm larva from the nose. Diagnosis was performed by morphological and molecular characterization, showing the causative agent to be a third-stage larva ofPseudoterranova decipiens(sensu stricto). Various infection routes are discussed.
Evidence for enemy release in invasive common daceLeuciscus leuciscusin Ireland: a helminth community survey and systematic review
Authors: Tierney P.A. , Caffrey J.M. , Matthews S.M. , Costantini E. , Holland C.V. 
Published: September 2020

AbstractInvasive species lose parasites in the process of invasion and tend to be less parasitized than conspecifics in the native range and sympatric native species in the invasive range (enemy release). We evaluated enemy release in an invasive freshwater fish in Ireland, common daceLeuciscus leuciscus, using helminth parasite community surveys at the core and front of the invasive range of common dace. Furthermore, we undertook a systematic literature review of helminth infection in common dace across its native range in Great Britain and Europe and invasive range in Ireland. The helminth parasite community survey revealed that invasive common dace were infected with fewer helminth species at the invasion front than at the core. Four helminth taxa – Acanthocephala, Monogenea, Digenea and Nematoda – were present in dace at the invasion core compared to only a single helminth species (Pomphorhynchus tereticollis) at the front. The systematic review revealed that invasive common dace in Ireland hosted fewer species of helminths than common dace in the native range. We report a total of three helminth species in common dace in Ireland compared to 24 in Great Britain and 84 in Continental Europe. Our results support the hypotheses that invasive populations are less parasitized than native populations and that more recently established populations host fewer parasites. However, we demonstrate that invasive species may continue to experience release from parasites long after initial invasion.
The Artistic Metaphor
Authors: Dixon Daisy 
Published: September 2020

AbstractPhilosophical analysis of metaphor in the non-linguistic arts has been biased towards what I call the ‘aesthetic metaphor’: metaphors in non-linguistic art are normally understood as being completely formed by the work'sinternalcontent, that is, by its perceptual and aesthetic properties such as its images. I aim to unearth and analyse a neglected type of metaphor also used by the non-linguistic arts: the ‘artistic metaphor’, as I call it. An artistic metaphor is composed by an artwork's internal content, but also by itsexternalcontent, which is provided by the work's artistic properties such as its history. The artistic metaphor has been gestured at but not afforded a considered analysis; I aim to do this. Identifying the artistic metaphor has at least two benefits. It shows how curation plays a role in generating metaphors in artworks, which has been overlooked, and it illuminates a potentially powerful tool to interpret and understand ‘conceptual’ art.
Can Multiple Realisation be Explained?
Authors: Franklin Alexander 
Published: September 2020

AbstractMultiple realisation prompts the question: how is it that multiple systems all exhibit the same phenomena despite their different underlying properties? In this paper I develop a framework for addressing that question and argue that multiple realisation can be reductively explained. I illustrate this position by applying the framework to a simple example – the multiple realisation of electrical conductivity. I defend my account by addressing potential objections:contra(e.g.) Polger and Shapiro (2016), Batterman (2018), and Sober (1999), I claim that multiple realisation is commonplace, that it can be reductively explained, but that it requires asui generisreductive explanatory strategy.
Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children
Authors: Aguilar-Lacasaña Sofía , Vilor-Tejedor Natàlia , Jansen Philip R. , López-Vicente Mònica , Bustamante Mariona , Burgaleta Miguel , Sunyer Jordi , Alemany Silvia 
Published: September 2020

AbstractBackgroundAttention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim to examine the genetic overlap between ADHD and ASD and cognitive measures of working memory (WM) and attention performance among schoolchildren using a polygenic risk approach.MethodsA total of 1667 children from a population-based cohort aged 7–11 years with data available on genetics and cognition were included in the analyses. Polygenic risk scores (PRS) were calculated for ADHD and ASD using results from the largest GWAS to date (N= 55 374 andN= 46 351, respectively). The cognitive outcomes included verbal and numerical WM and the standard error of hit reaction time (HRTSE) as a measure of attention performance. These outcomes were repeatedly assessed over 1-year period using computerized version of the Attention Network Test andn-back task. Associations were estimated using linear mixed-effects models.ResultsHigher polygenic risk for ADHD was associated with lower WM performance at baseline time but not over time. These findings remained significant after adjusting by multiple testing and excluding individuals with an ADHD diagnosis but were limited to boys. PRS for ASD was only nominally associated with an increased improvement on verbal WM over time, although this association did not survive multiple testing correction. No associations were observed for HRTSE.ConclusionsCommon genetic variants related to ADHD may contribute to worse WM performance among schoolchildren from the general population but not to the subsequent cognitive-developmental trajectory assessed over 1-year period.
Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial
Authors: Chan Joey WY , Lam SP , Li Shirley X , Chau Steven WH , Chan SY , Chan NY , Zhang JH , Wing YK 
Published: September 2020

AbstractBackgroundUnipolar non-seasonal depressed patients with concomitant evening chronotype were associated with poor clinical outcomes and higher non-remission rate. This study aims to examine the efficacy of adjunctive bright light therapy with gradual timing advance in a randomized, assessor and prescriber-blinded controlled trial.MethodParticipants were randomly allocated to receive 5 weeks of either bright white light therapy (BLT) or dim red light (DRL) with the same advancement protocol. Participants were followed up till 5 months after treatment. Primary outcomes included (i) remission rate and (ii) the severity of depression. The analysis was conducted using Kaplan–Meier survival analysis, Cox proportional hazard analysis and linear mixed models.ResultsA total of 93 participants (46.4 ± 11.7 years old, 80% female) were randomized. The cumulative remission rate for the BLT and the DRL groups was 67.4% and 46.7%, respectively. Time to remission was shorter for the BLT group relative to the DRL group (log-rank test p = 0.024). Cox proportional hazard survival analysis showed that patients in the BLT group had a higher probability of achieving remission relative to patients in the DRL group [hazard ratio = 1.9 (95% CI = 1.1– 3.4), p = 0.026]. Further sensitivity analysis demonstrated greater improvement in 17-Hamilton Depression Score (group × time interaction, p = 0.04) in the BLT group for those who were adherent to light therapy.ConclusionsThe use of bright light therapy with gradual advance protocol is an effective adjunctive treatment resulting in quicker and a higher rate of remission of depression in patients with non-seasonal unipolar depression and evening-chronotype.
Co-opting the neoliberal manhood ideal: Masculinity, normativity, and recursive normalisation in Serbian gay men's digital dating profiles
Authors: Bogetić Ksenija 
Published: September 2020

AbstractThis article investigates sexual and gender ideologies in online dating profiles of Sebian gay men using corpus-linguistic and discourse-analytic methods. Selected keywords are analysed in context, and particular attention is paid to collocation patterns, including grammatical collocates that are shown to carry discursive relevance beyond style. The analysis reveals that repeated associations centre on concepts of masculinity and normality, in a local indexical order of ‘proper’ manhood, sexuality, global modernity, and national identity. Overall, the texts are most strongly characterized by adversarial distance towards certain gay men, operating in normalizing assimilation to the national (heterosexual) citizen ideal. A broader mechanism, termed recursive normalisation, is described as underpinning the observed patterns. The findings are further discussed as highlighting the pitfalls of theory and social movements focused on social assimilation, arguing for the need for further queer linguistic deconstruction of the normalising discourses that intersect marginalized communities and broader, systemic hegemonies. (Gay men, online dating, masculinity, recursive normalization)
Global Leadership in Paediatric and Congenital Cardiac Care: “Using data to improve outcomes – an interview with Jennifer S. Li, MD, MHS”
Authors: Tretter Justin T. , Jacobs Jeffrey P. 
Published: September 2020

AbstractDr. Jennifer Li is the focus of our second in a planned series of interviews in Cardiology in the Young entitled, “Global Leadership in Paediatric and Congenital Cardiac Care”. Dr. Li was born in Boston, Massachusetts, United States of America, and moved to Indianapolis, Indiana where she completed her secondary education. She then attended Stanford University, majoring in Chemistry and English and graduating with distinction in 1983. Dr. Li then attended Duke University School of Medicine, graduating in 1987. She then completed her internship at Children’s Hospital of Philadelphia in 1987–1989, returning to Duke University Medical Center to complete both her residency in general paediatrics in 1989–1990 followed by her fellowship in paediatric cardiology in 1990–1993. She would later complete her Master’s Degree in Health Sciences at Duke University in 2005.Dr. Li has spent her entire career as a paediatric cardiologist at Duke University Medical Center, where she was appointed a Professor of Pediatrics and Professor of Medicine in 2008 and has held the position as Beverly C. Morgan Endowed Professor of Pediatrics since 2012. She has served as the Chief of Paediatric Cardiology at Duke University Medical Center since 2006. She also was the Director of Paediatric Research at Duke Clinical Research Institute from 2001-2015. Dr. Li has played an instrumental role in evaluating the safety and efficacy of drugs in children, as well as in analysing and linking large multicentric databases to evaluate the outcomes, quality, and cost of paediatric and congenital cardiac care. Dr. Li has received funding from the National Institute of Health of the United States of America, as well as from industry and foundation grants. This article presents our interview with Dr. Li, an interview that covers her experience collaborating with governmental organizations and industry in the pursuit of common interests to design clinical drug trials, link and analyse large, multicentric databases, and improve paediatric health care.
The complex interactions among serotonin, insulin, leptin, and glycolipid metabolic parameters in human obesity
Authors: Marazziti Donatella , Betti Laura , Baroni Stefano , Palego Lionella , Mucci Federico , Carpita Barbara , Cremone Ivan Mirco , Santini Ferruccio , Fabbrini Laura , Pelosini Caterina , Marsili Alessandro , Massimetti Enrico , Giannaccini Gino , Dell’Osso Liliana 
Published: September 2020

AbstractObjectiveTo provide evidence to the link between serotonin (5-HT), energy metabolism, and the human obese phenotype, the present study investigated the binding and function of the platelet 5-HT transporter (SERT), in relation to circulating insulin, leptin, and glycolipid metabolic parameters.MethodsSeventy-four drug-free subjects were recruited on the basis of divergent body mass index (BMIs) (16.5-54.8 Kg/m2). All subjects were tested for their blood glycolipid profile together with platelet [3H]-paroxetine ([3H]-Par) binding and [3H]-5-HT reuptake measurements from April 1st to June 30th, 2019.ResultsThe [3H]-Par Bmax (fmol/mg proteins) was progressively reduced with increasing BMIs (P < .001), without changes in affinity. Moreover, Bmax was negatively correlated with BMI, waist/hip circumferences (W/HC), triglycerides (TD), glucose, insulin, and leptin, while positively with high-density lipoprotein (HDL) cholesterol (P < .01). The reduction of 5-HT uptake rate (Vmax, pmol/min/109 platelets) among BMI groups was not statistically significant, but Vmax negatively correlated with leptin and uptake affinity values (P < .05). Besides, [3H]-Par affinity values positively correlated with glycemia and TD, while [3H]-5-HT reuptake affinity with glycemia only (P < .05). Finally, these correlations were specific of obese subjects, while, from multiple linear-regression analysis conducted on all subjects, insulin (P = .006) resulting negatively related to Bmax independently from BMI.ConclusionsPresent findings suggest the presence of a possible alteration of insulin/5-HT/leptin axis in obesity, differentially impinging the density, function, and/or affinity of the platelet SERT, as a result of complex appetite/reward-related interactions between the brain, gut, pancreatic islets, and adipose tissue. Furthermore, they support the foremost cooperation of peptides and 5-HT in maintaining energy homeostasis.
Imagine food, weight and shape: mental imagery in women with eating disorders compared with healthy controls
Authors: Hijne Kim , Ben Chamach Suzan , Dingemans Alexandra E. 
Published: September 2020

AbstractBackground:Research into mental disorders has found mental imagery to be a maintaining factor for psychological distress. However, studies investigating mental imagery in eating disorders are scarce.Aim:The aim of the present study was to compare spontaneous mental imagery related to eating, weight and/or appearance and intrusive prospective imagery in women with an eating disorder with female healthy controls.Methods:Spontaneous mental imagery and intrusive prospective imagery were assessed in adult women with an eating disorder (n= 29) and in female healthy controls (n= 32) using a semi-structured interview and the Impact of Future Events Scale, respectively.Results:In comparison with healthy controls, the spontaneous mental images in individuals with an eating disorder involved more sensory modalities (U= 156.50,p< .001,r= –.51), were more vivid (t(52) = 2.04,p= .047,d= .55), negative (U= 103.00,p< .001,r= –.62), and anxiety provoking (U= 158.50,p< .001,r= –.49), and were experienced with a lower sense of control (U= 215.00,p= .009,r= –.36). The emotional impact of intrusive prospective imagery (U= 105.00,p< .001,r= –.66) was also higher in individuals with an eating disorder, as was the number of negative prospective images (U= 283.00,p= .016,r= –.31).Conclusions:Our findings are consistent with previous research on mental imagery in other psychiatric disorders, and provide possibilities for incorporating imagery-based techniques in treatment interventions.
Determinants of exclusive breast-feeding discontinuation in southeastern Brazil, 2008–2013: a pooled data analysis
Authors: Nascimento Edinalva Neves , Leone Cláudio , de Abreu Luiz Carlos , Buccini Gabriela 
Published: September 2020

AbstractObjective:To analyse the determinants of exclusive breast-feeding (EBF) discontinuation in southeastern Brazil between 2008 and 2013.Design:Secondary cross-sectional data were analysed from three waves of child feeding surveys conducted in the city of Marília, São Paulo, Brazil, in 2008, 2011 and 2013 (n 1645 children under 6 months). Multivariable Poisson regression models were used to test the association between EBF discontinuation and socio-economic, demographic and biomedical factors in a pooled sample and within each survey wave.Setting:Regionally representative cross-sectional survey from Brazil.Participants:The analytical sample included 1645 infants under 6 months old.Results:In the pooled sample, 40·7 % of the infants were exclusively breastfed. Between 2008 and 2013, there was a significant increase in C-section (35·1–42·7 %) and pacifier use (41·4–48·8 %). The determinants of EBF discontinuation in the pooled analysis were mothers working outside the home (adjusted prevalence ratio (APR) = 1·10; 95 % CI 1·00, 1·21), first-time mothers (APR = 1·10; 95 % CI 1·01, 1·20), pacifier use (APR = 1·48; 95 % CI 1·36, 1·61) and low birth weight (APR = 1·17; 95 % CI 1·05, 1·32).Conclusions:Mothers working outside the home, first-time moms, pacifier use and low birth weight were the factors associated with EBF discontinuation. Evidence-based counselling strategies during antenatal and early postpartum care in primary healthcare are needed to address the modifiable determinants of EBF discontinuation and ultimately to improve its rates in southeastern Brazil.
Disparities in fresh fruit and vegetable intake by sociodemographic and behavioural factors among adults in China
Authors: Li Li , Ouyang Yifei , Wang Huijun , Huang Feifei , Wang Yun , Zhang Jiguo , Su Chang , Du Wenwen , Jia Xiaofang , Jiang Hongru , Wang Zhihong , Zhang Bing 
Published: September 2020

AbstractObjective:To measure the associations of sociodemographic and behavioural factors with fruit and vegetable consumption among adults in China.Design:A cross-sectional study.Setting:A 2015 wave of the China Health and Nutrition Survey.Participants:Totally, 11 910 adults aged 18 to 64 years.Results:Adjusted log binomial regression analyses showed that adults with higher income levels had higher fruit intake than those with low income levels (medium income group, risk ratio (RR): 1·28; 95 % CI: 1·16, 1·41; high income group, RR: 1·58; 95 % CI: 1·43, 1·74). Current smokers had lower fruit intake than non-smokers (RR: 0·86; 95 % CI: 0·77, 0·96). Adults living in southern China had higher vegetable intake (RR: 1·88; 95 % CI: 1·76, 2·01) but lower fruit intake (RR: 0·85; 95 % CI: 0·79, 0·91) than adults in northern China. With increasing age, adults had higher fruit intake (50–64 years, RR: 1·20; 95 % CI: 1·09, 1·33; reference category 18–34 years) and higher vegetable intake (35–49 years, RR: 1·13; 95 % CI: 1·05, 1·22; 50–64 years, RR: 1·22; 95 % CI: 1·13, 1·31).Conclusions:Our findings identify a range of sociodemographic and behavioural factors associated with fruit and vegetable consumption among Chinese adults. They also point to the need for public health nutrition interventions for socially disadvantaged populations in China.
High prevalence of food intolerances among US internet users
Authors: Jansson-Knodell Claire L , White Mattie , Lockett Carolyn , Xu Huiping , Shin Andrea 
Published: September 2020

AbstractObjective:Food intolerances are commonly reported and are predicted to have gastrointestinal health implications. We aimed to quantify the prevalence of food intolerances among US adults and identify culprit foods through a brief web-based survey.Design:We invited participation in an online cross-sectional survey involving a single questionnaire. Data were summarised using percentages or medians and interquartile range. Participant characteristics by self-reported food intolerance were compared using the Wilcoxon rank sum test and Pearson’sχ2test. Adjusted analyses were performed using multivariable logistic regression.Setting:The survey was internet-based via Amazon’s mechanical Turk, a crowdsourcing website for the completion of requester directed tasks.Participants:Adults who were US-based internet users were invited at ages 18–80.Results:We collected 2133 survey responses (ages 18–79 years). The rate of food intolerance was 24·8 % (95 % CI 23·0, 26·6) in US adults. Younger (P< 0·01), female (P= 0·05) and Asian, African American or multiple race individuals (P< 0·01) predominated. Lactose intolerance was most common. Frequency of a non-lactose food intolerance was 18·1 % (95 % CI 16·5, 19·8). When categorised broadly, grains, fruit, lactose, fish, vegetables, alcohol and nuts were most troublesome for individuals in that order.Conclusions:Self-reported food intolerance is common in US internet users. The effect of food on gastrointestinal symptoms and avoidant behaviours deserves further attention.
Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy
Authors: Stelwagen Johannes , Lubberts Sjoukje , Steggink Lars C. , Steursma Gerrie , Kruyt Lara M. , Donkerbroek Jan Willem , van Roon Arie M. , van Gessel Anne I. , van de Zande Saskia C. , Meijer Coby , Gräfin zu Eulenburg Christine H. , Oosting Sjoukje F. , Nuver Janine , Walenkamp Annemiek M. E. , Jan de Jong Igle , Lefrandt Joop D. , Gietema Jourik A. 
Published: September 2020

AbstractBackgroundLate effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS.MethodsTCS (treated with chemotherapy or orchiectomy only) and age-matched healthy controls were invited. Study assessment included vascular stiffness with ultrasound measurement of carotid-femoral pulse wave velocity (cf-PWV).ResultsWe included 127 TCS consisting of a chemotherapy group (70 patients) and an orchiectomy group (57 patients) along with 70 controls. Median follow-up was 28 years (range: 20–42). The cf-PWV (m/s) was higher in TCS than in controls (geometrical mean 8.05 (SD 1.23) vs. 7.60 (SD 1.21),p = 0.04). The cf-PWV was higher in the chemotherapy group than in the orchiectomy group (geometrical mean 8.39 (SD 1.22) vs. 7.61 (SD 1.21),p < 0.01). In the chemotherapy group cf-PWV increased more rapidly as a function of age compared to controls (regression coefficientb7.59 × 10−3vs. 4.04 × 10−3;p = 0.03).ConclusionVery long-term TCS treated with cisplatin-based chemotherapy show increased vascular damage compatible with “accelerated vascular aging” and continue to be at risk for cardiovascular morbidity, thus supporting the need for intensive cardiovascular risk management.Clinical trial registrationThe clinical trial registration number is NCT02572934.