bluuebunny/crossref_metadata_2025_split huggingface dataset:
CA9 transcriptional expression determines prognosis and tumour grade in tongue squamous cell carcinoma patients
Authors: Guan Chenyu , Ouyang Daiqiao , Qiao Yongjie , Li Kan , Zheng Guangsen , Lao Xiaomei , Zhang Sien , Liao Guiqing , Liang Yujie 
Published: April 2020

AbstractCA9 is a member of the carbonic anhydrases’ family, that is often expressed in cancer cells under hypoxic condition. However, the role of CA9 in the molecular mechanisms of tongue squamous cell carcinoma (TSCC) pathogenesis remains unclear. CA9 expression was analysed using the TCGA database, and its influence on survival was performed using Kaplan‐Meier, LASSO and COX regression analyses. The correlation between CA9 and immune infiltration was investigated by CIBERSORT and ESTIMATE. Moreover, the relationship between CA9 expression and downstream molecular regulation pathways was analysed by GSEA, GO and WGCNA. CA9 expression correlated with clinical prognosis and tumour grade in TSCC. Moreover, CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour‐associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF‐beta signalling pathways. However, the follicular helper T cells, regulatory T cells, immune and stromal scores showed no significance between high and low CA9 expression groups. These findings suggested that CA9 plays a critical role of TSCC prognosis and tumour grade. CA9 expression significantly correlated with the regulation of cell differentiation, various oncogenes and cancer‐associated pathways.
The nursing practice environment and nurse job outcomes: A path analysis of survey data
Authors: Ambani Zainab , Kutney‐Lee Ann , Lake Eileen T. 
Published: April 2020

AbstractAims and objectivesTo assess the nursing practice environments and nurse job‐related outcomes in two types of hospitals in Saudi Arabia.BackgroundThe nursing shortage is a challenging problem in Saudi hospitals. Studies have shown that poor practice environments and high patient‐to‐nurse ratios are associated with poor nurse job outcomes (i.e. job dissatisfaction, burnout and intention to leave) and that can lead to nurse turnover and compound the nursing shortage. However, little research has been conducted on this topic in Saudi Arabia.DesignA cross‐sectional design. A model that links the nursing practice environment and patient‐to‐nurse ratio to nurse job outcomes was tested through a path analysis of survey data.MethodsA sample of 404 nurses from public and military hospitals in Saudi Arabia completed a survey that included the Practice Environment Scale of the Nursing Work Index, the Maslach Burnout Inventory and questions related to job dissatisfaction and intention to leave the job. A model of nurse turnover was used to test the relationships among study variables. This study was carried out in accordance with the STROBE checklist for cross‐sectional studies.ResultsThe nursing practice environment and nurse job outcomes were better in military hospital compared with public hospital. Overall, 53% of participants had high burnout, 39% were dissatisfied, and 26% intended to leave their jobs. The path analysis showed that the nursing practice environment and patient‐to‐nurse ratio were predictors of burnout and job dissatisfaction, which in turn lead to intention to leave. The tested model had good fit and explained the direct and indirect effects of study variables.ConclusionPoor nursing practice environments and high patient‐to‐nurse ratios contribute to poor nurse job outcomes in Saudi hospitals.Relevance to clinical practiceNurse leaders can focus on enhancing practice environments and reducing patient‐to‐nurse ratios as retention strategies to improve nurse job outcomes.
Nurses' job involvement and association with continuing current position—A descriptive comparative study
Authors: Nylén‐Eriksen Mats , Grov Ellen Karine , Bjørnnes Ann Kristin 
Published: April 2020

AbstractAims and objectivesThe aim of the study is to examine nurses' job involvement and intentions to continue in their current position.BackgroundGlobally, the supply of nurses fails to meet the labour markets' high demand. Compared to specialist health service, the community health service has the greatest challenge when it comes to nursing shortage. There is a lack of studies comparing nurses working in different parts of the healthcare system in research focusing on nurses' intentions to continue in their current position. Similarly, there has been relatively little research on nurses' job involvement, even less how it is associated with retaining the nurses, despite indications that job involvement may be the key to job‐related motivated behaviour.DesignA descriptive comparative study with a cross‐sectional design.MethodsThe study comprises 297 nurses from the community health service and specialist health service, respectively. The relationships between nurses' intention to continue and participant characteristics were examined using binary logistic regression. Reporting followed the STROBE guidelines.ResultsNurses in the community health service are older, have more children under the age of 18 and hold more permanent positions than nurses in the specialist health service. Job involvement is the only variable associated with nurses' intention to continue in their current position regardless of whether the nurse works in the community health service or specialist health service.ConclusionsThe results indicate that the community health service has the same possibilities as the specialist health service to retain nurses in their current jobs.Relevance to clinical practiceThe results indicate that nursing leaders/employers with a goal to retaining nurses are recommended to focus on improving the nurses' job involvement.
Can a pragmatic responsive feeding scale be developed and applied globally?
Authors: Pérez‐Escamilla Rafael , Segura‐Pérez Sofia 
Published: April 2020

AbstractResponsive feeding (RF) has been recognized as necessary to prevent all forms of malnutrition including stunting and childhood obesity. Specific RF guidelines have been developed, but it is unclear how RF behaviours can be monitored systematically. Therefore, developing valid and reliable abbreviated and pragmatic RF scales is an important global priority. This is challenging, as RF is a construct with multiple dimensions including recognizing and responding to hunger and satiety cues, providing a nurturing environment during feeding episodes, and understanding how feeding needs evolve as a function of the developmental stage of the young child. Further, RF is embedded within the responsive parenting framework that in addition to RF includes sleep, soothing and play routines and the interconnections between them. A recent pioneer study conducted in a rural area of Cambodia validated an 8‐item RF scale through direct feeding observations of 6‐ to 23‐month‐old infants at home, as part of two cross‐sectional surveys conducted before and after a complementary feeding intervention. It is important for similar research to be conducted elsewhere to find out if it is possible or not to develop a core RF scale that is valid and reliable and that has adequate specificity and sensitivity for application in community studies and population surveys globally. As highlighted in this article, different definitions of RF have been used in the field; thus, it is important to reach consensus on a single definition to help move this research area forward.
Burden of serious fungal infections in the Netherlands
Authors: Buil Jochem B. , Meijer Eelco F. J. , Denning David W. , Verweij Paul E. , Meis Jacques F. 
Published: April 2020

SummaryBackgroundFungal diseases have an ever‐increasing global disease burden, although regional estimates for specific fungal diseases are often unavailable or dispersed.ObjectivesHere, we report the current annual burden of life‐threatening and debilitating fungal diseases in the Netherlands.MethodsThe most recent available epidemiological data, reported incidence and prevalence of fungal diseases were used for calculations.ResultsOverall, we estimate that the annual burden of serious invasive fungal infections in the Netherlands totals 3 185 patients, including extrapulmonary or disseminated cryptococcosis (n = 9), pneumocystis pneumonia (n = 740), invasive aspergillosis (n = 1 283), chronic pulmonary aspergillosis (n = 257), invasive Candida infections (n = 684), mucormycosis (n = 15) and Fusarium keratitis (n = 8). Adding the prevalence of recurrent vulvo‐vaginal candidiasis (n = 220 043), allergic bronchopulmonary aspergillosis (n = 13 568) and severe asthma with fungal sensitisation (n = 17 695), the total debilitating burden of fungal disease in the Netherlands is 254 491 patients yearly, approximately 1.5% of the country's population.ConclusionWe estimated the annual burden of serious fungal infections in the Netherlands at 1.5% of the population based on previously reported modelling of fungal rates for specific populations at risk. With emerging new risk groups and increasing reports on antifungal resistance, surveillance programmes are warranted to obtain more accurate estimates of fungal disease epidemiology and associated morbidity and mortality.
Hour‐specific nomogram for transcutaneous Bilirubin in newborns in Myanmar
Authors: Yasuda Saneyuki , Suzuki Hiromi , Htun Yinmon , Aye Nant San San , Oo Hnin , Oo Aung Ko , Yu Kay Zin , Sin Khine Shwe , Itoh Susumu , Kusaka Takashi 
Published: April 2020

AbstractBackgroundNeonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries. Non‐invasive methods for early detection and treatment of hyperbilirubinemia are urgently needed. In this study, we used transcutaneous bilirubin (TcB) measurements to develop an hour‐specific TcB nomogram for the effective management of hyperbilirubinemia in Myanmar newborns.MethodsThe bilirubin levels of neonates born in Central Women Hospital in Yangon, Myanmar were measured three times a day within 72 h after birth using a transcutaneous bilirubinometer. An hour‐specific TcB nomogram was created based on the data.ResultsParticipants were 512 infants (287 boys, 225 girls) born in Central Women’s Hospital in Yangon. The mean (±SD) gestational age was 38.4 ± 1.2 weeks; birthweight was 3078 ± 412 g. A total of 3,039 plots were obtained, and the TcB nomogram was created with smoothed percentile curves (97.5th, 50th, and 2.5th percentiles) for 0–72 h after birth.ConclusionsAn hour‐specific TcB nomogram was successfully created to manage hyperbilirubinemia in Myanmar newborns.
An exploratory survey of public health nurses’ knowledge, skills, attitudes, and application of the Quad Council Competencies
Authors: Harmon Monica , Joyce Barbara L. , Johnson Regina (Gina) H. , Hicks Vicki , Brown‐Schott Nancy , Pilling Lucille , Collinge Rachelle , Brownrigg Vicki 
Published: April 2020

AbstractObjectiveA collaborative research team of community/public health nursing faculty and public health nurses surveyed public health nurses to explore knowledge, skills, attitudes, and application of the Quad Council Competencies for Public Health Nurses (QCC‐PHN).MethodsEvaluate the knowledge, skills, attitudes, and application of the 2011 QCC‐PHN by public health nurses.DesignA descriptive, cross‐sectional design was used to answer the hypothesis related to the study objective. A convenience sample of 308 public health nurses completed an online survey.MeasurementsANOVA was used to determine the difference between the knowledge, skills, attitudes, and application of community/public health nurses (C/PHNs) regarding the QCC‐PHN based on nursing specialty preparation, years of nursing experience, and years of C/PHN experience.ResultsC/PHNs are described and differences in knowledge, skills, attitudes, and application are delineated. A statistically significant difference was found in knowledge and attitude based upon years of C/PHN experience.ConclusionsRecommendations are proposed for increasing the QCC‐PHN awareness, implementation, and evaluation to effectively enhance the practice of nursing C/PHN.
Identification of appropriate reference genes for qPCR analyses of porcine placentae and endometria, supplying foetuses of different size and sex, at multiple gestational days
Authors: Stenhouse Claire , Hogg Charis O. , Ashworth Cheryl J. 
Published: April 2020

AbstractRecent studies suggest associations exist between foetal size and sex, and gene expression at the porcine feto‐maternal interface. It is essential to identify reference genes which have stable expression throughout gestation in feto‐placental units associated with foetuses of different size and sex. qPCR was performed for 11 genes within porcine placentae and endometria at gestational days (GD) 30, 60 and 90. Several reference genes were found to have stable expression in these samples. The combination of B2m1 and Tbp1, and Hprt1 and Tbp1 had the most stable expression in endometria and placentae, respectively. Reference genes identified as having stable expression were utilized in a larger experiment with placentae and endometria associated with foetuses of different size and sex at four GD. The average expression of B2m1 and Tbp1 mRNAs was suitable for the normalization of temporal changes in endometria, and comparison between endometria supplying foetuses of different size throughout gestation. The average expression of Hprt1 and Tbp1 mRNAs was suitable for the normalization of placental mRNA expression for comparison of temporal changes and sex differences between placentae supplying foetuses of different sex throughout gestation. This combination was suitable for the normalization of mRNA expression in placentas supplying GD30, GD60 and GD90 foetuses of different size. This study has identified reference genes with stable expression in placentae and endometria across multiple gestational days, in tissues associated with foetuses of different size and sex. The results of these experiments highlight the importance of selecting appropriate reference genes for the biological comparison under investigation.
Reservoir architecture and heterogeneity distribution in floodplain sandstones: Key features in outcrop, core and wireline logs
Authors: Yeste Luis Miguel , Varela Augusto N. , Viseras César , Mcdougall Neil D. , García‐García Fernando 
Published: April 2020

AbstractExploration and production from formations deposited in low‐gradient fluvial systems is typically associated with a high degree of uncertainty; a reflection of the inherent characteristics of these environments, notably the dominance of non‐reservoir floodplain fines, rapid lateral facies variations and associated heterogeneities at different scales. However, for a field development to be successful it becomes crucial to know the location, geometry, dimensions and connectivity of the most permeable facies, related to the main channel and the associated proximal overbank deposits (crevasse‐splay complexes). With the aim of addressing this problem, a multi‐disciplinary study is presented, combining outcrop data, high‐resolution sedimentological descriptions and advanced visualization techniques based on Digital Outcrop Models. This is compared with subsurface data from behind the outcrop (core, gamma ray and borehole image logs). The Mudstone–Sandstone Unit of the Triassic Red Beds of Iberian Meseta formation in south‐central Spain was selected for the present study. The unit is characterized by the lateral and vertical stacking of four architectural elements: (i) channelized sandstone bodies; (ii) asymmetrical sigmoidal‐shaped sandstone bodies; (iii) lobe‐shaped to sheet‐like sandstone bodies; and (iv) sheet‐like mudstones. These elements represent meandering channel, crevasse‐channel‐splay and floodplain sub‐environments, comprising a distal, low‐gradient meandering fluvial system. Together with well‐documented outcrop and core facies, calibrated log responses are also presented for the channel bodies (bell‐shape Gamma Ray profile, random azimuths and low to high dip angles), the crevasse‐splay bodies (funnel‐shape Gamma Ray profile, unidirectional azimuths and low dip angles) and the floodplain deposits (serrated Gamma Ray profile, unidirectional azimuths and very low dip angles). The full integration of outcrop and subsurface datasets has enabled generation of a robust conceptual model with predictive potential when establishing the three‐dimensional stacking of facies, distribution of heterogeneities, and the connectivity between reservoir rock geobodies of primary (channel) and secondary (crevasse complex) interest in this type of fluvial reservoir.
Concurrent Thermal and Electrical Property Effects of Nano-Enhanced Phase Change Material for High-Voltage Electronics Applications
Authors: Iradukunda Ange-Christian , Kasitz Josh , Carlton Hayden , Huitink David , Deshpande Amol , Luo Fang 
Published: April 2020

Abstract
Rapid temperature transients sustained during the operation of high-voltage electronics can be difficult to manage by relying solely on uniform heat removal mechanisms. Phase-change materials (PCMs) can be useful as a buffer against these intermittent temperature spikes when integrated into electronic packages. However, their integration poses challenges of both physical and electrical interactions within the package, particularly in high-voltage systems. This study aims to evaluate electrical and thermal properties of nano-enhanced PCMs to inform their integration in high-voltage systems. The nanocomposites are obtained by seeding 3 × 10−5 and 3 × 10−4 wt % of gold and iron oxide particles to sorbitol. Improvements in thermal properties including thermal conductivity as high as 8% are observed; however, this comes at the expense of the dielectric strength of the PCM. Additionally, an implementation scheme for the nano-enhanced PCMs in a high-voltage-capable power module is proposed with accompanying computational and experimental performance data.
Recalibrating the risk of hamstring strain injury (HSI): A 2020 systematic review and meta-analysis of risk factors for index and recurrent hamstring strain injury in sport
Authors: Green Brady , Bourne Matthew N , van Dyk Nicol , Pizzari Tania 
Published: April 2020

ObjectiveTo systematically review risk factors for hamstring strain injury (HSI).DesignSystematic review update.Data sourcesDatabase searches: (1) inception to 2011 (original), and (2) 2011 to December 2018 (update). Citation tracking, manual reference and ahead of press searches.Eligibility criteria for selecting studiesStudies presenting prospective data evaluating factors associated with the risk of index and/or recurrent HSI.MethodSearch result screening and risk of bias assessment. A best evidence synthesis for each factor and meta-analysis, where possible, to determine the association with risk of HSI.ResultsThe 78 studies captured 8,319 total HSIs, including 967 recurrences, in 71,324 athletes. Older age (standardised mean difference=1.6, p=0.002), any history of HSI (risk ratio (RR)=2.7, p<0.001), a recent HSI (RR=4.8, p<0.001), previous anterior cruciate ligament (ACL) injury (RR=1.7, p=0.002) and previous calf strain injury (RR=1.5, p<0.001) were significant risk factors for HSI. From the best evidence synthesis, factors relating to sports performance and match play, running and hamstring strength were most consistently associated with HSI risk. The risk of recurrent HSI is best evaluated using clinical data and not the MRI characteristics of the index injury.Summary/conclusionOlder age and a history of HSI are the strongest risk factors for HSI. Future research may be directed towards exploring the interaction of risk factors and how these relationships fluctuate over time given the occurrence of index and recurrent HSI in sport is multifactorial.
Personalised yoga for burnout and traumatic stress in junior doctors
Authors: Taylor Jennifer , McLean Loyola , Richards Bethan , Glozier Nicholas 
Published: April 2020

AbstractObjectivesJunior doctors are frequently exposed to occupational and traumatic stress, sometimes with tragic consequences. Mindfulness-based and fitness interventions are increasingly used to mitigate this, but have not been compared.We conducted a randomised, controlled pilot trial to assess the feasibility, acceptability and effectiveness of these interventions in junior doctors.MethodsWe randomised participants (n=21) to weekly 1-hour sessions of personalised, trauma-informed yoga (n=10), with a 4-hour workshop, and eHealth homework; or group-format fitness (n=8) in an existing wellness programme, MDOK. Burnout, traumatic stress and suicidality were measured at baseline and 8 weeks.ResultsBoth interventions reduced burnout, and yoga increased compassion satisfaction within group on the Professional Quality of Life scale, without difference between groups on this measure.Personalised yoga significantly reduced depersonalisation (z=−1.99, p=0.05) compared with group fitness on the Maslach Burnout Inventory (MBI-HSS (MP)) and showed greater flexibility changes. Both interventions increased MBI Personal Accomplishment, with no changes in other self-report psychological or physiological metrics, including breath-counting.Participants doing one-to-one yoga rated it more highly overall (p=0.02) than group fitness, and reported it comparatively more beneficial for mental (p=0.01) and physical health (p=0.05). Face-to-face weekly sessions were 100% attended in yoga, but only 45% in fitness.ConclusionIn this pilot trial, both yoga and fitness improved burnout, but trauma-informed yoga reduced depersonalisation in junior doctors more than group-format fitness. One-to-one yoga was better adhered than fitness, but was more resource intensive. Junior doctors need larger-scale comparative research of the effectiveness and implementation of individual, organisational and systemic mental health interventions.Trial registration numberANZCTR 12618001467224.
Current State of Geospatial Methodologic Approaches in Canadian Population Oncology Research
Authors: Simkin Jonathan , Erickson Anders C. , Otterstatter Michael C. , Dummer Trevor J.B. , Ogilvie Gina 
Published: April 2020

Abstract
Geospatial analyses are increasingly used in population oncology. We provide a first review of geospatial analysis in Canadian population oncology research, compare to international peers, and identify future directions. Geospatial-focused peer-reviewed publications from 1992–2020 were compiled using PubMed, MEDLINE, Web of Science, and Google Scholar. Abstracts were screened for data derived from a Canadian cancer registry and use of geographic information systems. Studies were classified by geospatial methodology, geospatial unit, location, cancer site, and study year. Common limitations were documented from article discussion sections. Our search identified 71 publications using data from all provincial and national cancer registries. Thirty-nine percent (N = 28) were published in the most recent 5-year period (2016–2020). Geospatial methodologies included exposure assessment (32.4%), identifying spatial associations (21.1%), proximity analysis (16.9%), cluster detection (15.5%), and descriptive mapping (14.1%). Common limitations included confounding, ecologic fallacy, not accounting for residential mobility, and small case/population sizes. Geospatial analyses are increasingly used in Canadian population oncology; however, efforts are concentrated among a few provinces and common cancer sites, and data are over a decade old. Limitations were similar to those documented internationally, and more work is needed to address them. Organized efforts are needed to identify common challenges, develop leading practices, and identify shared priorities.