bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is managerial entrenchment always bad and corporate social responsibility always good? A cross‐national examination of their combined influence on shareholder value
Authors: Surroca Jordi A. , Aguilera Ruth V. , Desender Kurt , Tribó Josep A. 
Published: January 2020

AbstractResearch summaryBuilding on the comparative capitalism's notion of institutional complementarities, we examine whether firms’ simultaneous adoption of managerial entrenchment provisions (MEPs) and corporate social responsibility (CSR) reinforces or undercuts one another in influencing firm financial performance. We propose that the financial impact of such configurations is contingent on the country's institutional setting. In Liberal Market Economies (LMEs), where firms face strong pressures to achieve short‐term goals, the combination of MEPs and CSR creates shareholder value, particularly when firms engage in internally oriented CSR projects. Conversely, in Coordinated Market Economies (CMEs), where institutions already curb short‐term demands, the combined adoption of MEPs and CSR initiatives destroys shareholder value, particularly when this CSR is external. Overall, our study enhances understanding of the institutional complementarity between corporate governance and CSR.Managerial summaryThis study examines how two organizational practices, managerial entrenchment provisions (MEPs), and corporate social responsibility (CSR), combine between them to improve or reduce firms’ financial success. Our analysis demonstrates that institutional framework has a strong influence on their combined effect. When the institutional context supports solutions to coordination problems among economic agents through market‐based arrangements, MEPs allow the implementation of strategies directed to promote long‐term investments and relationships. In this case, MEPs when paired with CSR allow generating intangibles that contribute to create shareholder value. Contrarily, in frameworks with coordination mechanisms based on nonmarket arrangements, the joint adoption of MEPs and CSR destroys value by increasing the power of managers and blockholders to extract rents at the expense of firms’ minority shareholders.
Triangulated children's reality: Medical model's concealing effect versus family systems' revealing effect
Authors: Neophytou Kleanthis , Rodríguez‐González Martiño 
Published: January 2020

AbstractArguably, the medical model's narrative achieved an iconic mental health status eulogized within our evidence‐based era. Despite Diagnostic and Statistical Manual of Mental Disorders' atheoretical pretensions, we attempt to shed light and critically challenge its dogmatic mental health presumptions through a family systems perspective. Specifically, our critical study of a fictitious vignette attempts to expose how the medical model's systematic de‐emphasis of familial environments directs clinicians away from the true source of triangulated children's distress, an attention shift that may result in unintentionally perpetuating children's psychological turmoil. Alternatively, we attempt to delineate how the system paradigm may holistically account for children's familial emotional environments, thereby potentially attributing their psychological distress to its true, yet concealed, familial dysfunction. In essence, we argue that the medical model seems to operate within a decontextualized restricted disease‐carrier‐child mind frame, hence potentially ascribing faux diagnoses and false medical treatments to healthy children.
A randomized, 3-arm, neoadjuvant, phase 2 study comparing docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP), TCbHP followed by trastuzumab emtansine and pertuzumab (T-DM1+P), and T-DM1+P in HER2-positive primary breast cancer
Authors: Masuda Norikazu , Ohtani Shoichiro , Takano Toshimi , Inoue Kenichi , Suzuki Eiji , Nakamura Rikiya , Bando Hiroko , Ito Yoshinori , Ishida Kazushige , Yamanaka Takashi , Kuroi Katsumasa , Yasojima Hiroyuki , Kasai Hiroi , Takasuka Tsuyoshi , Sakurai Takaki , Kataoka Tatsuki R. , Morita Satoshi , Ohno Shinji , Toi Masakazu 
Published: January 2020

Abstract
Purpose
The standard of care in the neoadjuvant setting for human epidermal growth factor receptor 2 (HER2)-positive breast cancer is dual HER2-targeted therapy. However, a need to minimize treatment-related toxicity and improve pathological complete response (pCR) rates, particularly in luminal HER2-positive disease, exists.

Methods
Neopeaks, a randomized, phase 2 study, compared docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP; 6 cycles; group A), TCbHP (4 cycles) followed by trastuzumab emtansine + pertuzumab (T-DM1+P; 4 cycles; group B), and T-DM1+P (4 cycles; group C) regimens in HER2‐positive primary breast cancer patients; concurrent hormone therapy with T-DM1+P was administered in case of estrogen receptor positivity (ER+). Based on tumor shrinkage, nonresponders in group C were switched to 5-fluorouracil + epirubicin + cyclophosphamide (FEC; 4 cycles). Primary endpoint was pCR (comprehensive pCR ypN0 [ypT0-TisypN0]).

Results
Of 236 patients enrolled, 204 were randomized to groups A (n = 51), B (n = 52), and C (n = 101). In group C, 80 (79%) patients continued T-DM1+P following favorable response, whereas 21 (21%) nonresponders switched to FEC. pCR rate was numerically higher with the TCbHP →  T-DM1+P regimen (71%) versus the standard TCbHP (57%) and T-DM1+P (57%) regimens. The rate in group C was higher among responders continuing T-DM1+P (63%) versus nonresponders who switched to FEC (38%). pCR rates after initial 4 cycles of T-DM1+P (group C; 57%) and standard TCbHP regimen (57%) were equivalent. pCR rate in patients with ER+ was significantly higher in group B (69%) than groups A (43%) and C (51%), but was comparable in patients with ER− (67–76%). Compared with the T-DM1-based arm, the incidence of adverse events was higher in the taxane-based arms.

Conclusion
In the neoadjuvant setting, the pCR rate with the standard TCbHP →  T-DM1+P regimen was numerically better than the TCbHP regimen alone and significantly better in patients with ER+. Personalization of the T-DM1+P regimen could serve as a reasonable approach to minimize toxicity while maintaining efficacy.
Trial registration ID: UMIN-CTR: UMIN000014649.
Effects of baseline heart rate at sea level on cardiac responses to high-altitude exposure
Authors: Tian Jingdu , Liu Chuan , Yang Yuanqi , Yu Shiyong , Yang Jie , Zhang Jihang , Ding Xiaohan , Zhang Chen , Rao Rongsheng , Zhao Xiaohui , Huang Lan 
Published: January 2020

AbstractHigh-altitude (HA) exposure has been widely considered as a cardiac stress, and associated with altered cardiac function. However, the characteristics of cardiac responses to HA exposure are unclear. In total, 240 healthy men were enrolled and ascended to 4100 m by bus within 7 days. Standard echocardiography and color tissue Doppler imaging were performed at sea level and at 4100 m. In all subjects, HA exposure increased HR [65 (59, 71) vs. 72 (63, 80) beats/min, p < 0.001] but decreased the stroke volume index (SVi) [35.5 (30.5, 42.3) vs. 32.9 (27.4, 39.5) ml/m2, p < 0.001], leading to an unchanged cardiac index (CI). Moreover, baseline HR was negatively correlated with HA exposure-induced changes in HR (r = − 0.410, p < 0.001) and CI (r = − 0.314, p < 0.001). Following HA exposure, subjects with lowest tertile of baseline HR showed an increased HR [56 (53, 58) vs. 65 (58, 73) beats/min, p < 0.001], left ventricular ejection fraction (LVEF) [61.7 (56.5, 68.0) vs. 66.1 (60.7, 71.5) %, p = 0.004] and mitral S′ velocity [5.8 ± 1.4 vs. 6.5 ± 1.9 cm/s, p = 0.040]. However, subjects with highest tertile of baseline HR showed an unchanged HR, LVEF and mitral S′ velocity, but a decreased E′ velocity [9.2 ± 2.0 vs. 8.4 ± 1.8 cm/s, p = 0.003]. Our findings indicate that baseline HR at sea level could determine cardiac responses to HA exposure; these responses were characterized by enhanced LV function in subjects with a low baseline HR and by reduced LV myocardial velocity in early diastole in subjects with a high baseline HR.
Relaxing the strong triadic closure problem for edge strength inference
Authors: Adriaens Florian , De Bie Tijl , Gionis Aristides , Lijffijt Jefrey , Matakos Antonis , Rozenshtein Polina 
Published: January 2020

AbstractSocial networks often provide only a binary perspective on social ties: two individuals are either connected or not. While sometimes external information can be used to infer thestrengthof social ties, access to such information may be restricted or impractical to obtain. Sintos and Tsaparas (KDD 2014) first suggested to infer the strength of social ties from the topology of the network alone, by leveraging theStrong Triadic Closure(STC) property. The STC property states that if personAhas strong social ties with personsBandC,BandCmust be connected to each other as well (whether with a weak or strong tie). They exploited this property to formulate the inference of the strength of social ties as a NP-hard maximization problem, and proposed two approximation algorithms. We refine and improve this line of work, by developing a sequence of linear relaxations of the problem, which can be solved exactly in polynomial time. Usefully, these relaxations infer more fine-grained levels of tie strength (beyond strong and weak), which also allows one to avoid making arbitrary strong/weak strength assignments when the network topology provides inconclusive evidence. Moreover, these relaxations allow us to easily change the objective function to more sensible alternatives, instead of simply maximizing the number of strong edges. An extensive theoretical analysis leads to two efficient algorithmic approaches. Finally, our experimental results elucidate the strengths of the proposed approach, while at the same time questioning the validity of leveraging the STC property for edge strength inference in practice.
Discrepancies in purposes of student course evaluations: what does it mean to be “satisfied”?
Authors: Borch Iris , Sandvoll Ragnhild , Risør Torsten 
Published: January 2020

AbstractStudent evaluation of teaching is a multipurpose tool that aims to improve and assure educational quality. Improved teaching and student learning are central to educational enhancement. However, use of evaluation data for these purposes is less robust than expected. This paper explores how students and teachers perceive how different student evaluation methods at a Norwegian university invite students to provide feedback about aspects relevant to their learning processes. We discuss whether there are characteristics of the methods themselves that might affect the use of student evaluation. For the purpose of this study, interviews with teachers and students were conducted, and educational documents were analysed. Results indicated that evaluation questions in surveys emerged as mostly teaching-oriented, non-specific and satisfaction-based. This type of question did not request feedback from students about aspects that they considered relevant to their learning processes. Teachers noted limitations with surveys and said such questions were unsuitable for educational enhancement. In contrast, dialogue-based evaluation methods engaged students in discussions about their learning processes and increased students’ and teachers’ awareness about how aspects of courses improved and hindered students’ learning processes. Students regarded these dialogues as valuable for their learning processes and development of communication skills. The students expected all evaluations to be learning oriented and were surprised by the teaching focus in surveys. This discrepancy caused a gap between students’ expectations and the evaluation practice. Dialogue-based evaluation methods stand out as a promising alternative or supplement to a written student evaluation approach when focusing on students’ learning processes.
The United Nations Office on Drugs and Crime’s Efforts to Strengthen a Culture of Prevention in Low- and Middle-Income Countries
Authors: Heikkilä Hanna , Maalouf Wadih , Campello Giovanna 
Published: January 2020

AbstractThis article discusses how decision-makers can be supported to strengthen a culture of prevention. This article presents an example of the United Nations Office on Drugs and Crime’s (UNODC) work to engage with decision-makers to create readiness, demand, and capacity for evidence-based prevention programming among them, particularly in low- and middle-income countries. First, we utilized two of the UNODC’s data sources to describe the context where the UNODC’s prevention efforts take place. Analysis of the first dataset on prevention activities implemented globally revealed a gap in translating evidence into practice on a global scale. The second dataset consisted of UNODC policy documents mandating and guiding global action to address substance use. The analysis showed that at the level of political frameworks, prevention is gradually gaining more attention but is still frequently left in the shadow of health- and law enforcement-related issues. In addition, these guiding documents did not reflect fully the current scientific understanding of what constitutes an effective prevention response. Against this background, the feasibility of the UNODC’s efforts to bridge the science–practice gap in the field of prevention was discussed by presenting the results from the UNODC’s regional capacity-building seminars focused on the role of monitoring and evaluation in prevention programming. The results showed potential of this capacity building to affect the attitudes and knowledge of targeted decision-makers. Such efforts to increase decision-makers’ readiness and ultimately their endorsement, adoption, and ongoing support of evidence-based preventive interventions should be continued and intensified.
Awake Endoscopic Transforaminal Lumbar Interbody Fusion: A Technical Note
Authors: Butler Alexander J. , Brusko G. Damian , Wang Michael Y. 
Published: January 2020

Background Advances in modern spinal fusion techniques have allowed for less peri-operative morbidity and more rapid recovery from surgery. The addition of endoscopy to minimally invasive surgery (MIS) fusion techniques represents the latest progression of efforts to minimize the impact of surgical intervention. Technique MIS transforaminal lumbar interbody fusion (TLIF) is performed endoscopically through a sub-centimeter working portal. Patients undergo light conscious sedation and remain awake to facilitate feedback with the surgeon and enhance post-operative recovery. Results Previously reported results of the first 100 cases performed by the senior author at a single institution are summarized. This cohort has been characterized by brief post-operative length of stay, low complication profile, and marked improvement in patient-reported outcomes scores, with no cases of pseudarthrosis at 1-year follow up. Conclusions The latest technical considerations and adaptations of a novel technique for endoscopic MIS spinal fusion without general anesthesia are described. A refined surgical technique and anesthetic protocol are presented in detail with recommendations for the successful implementation and performance of the procedure.
The mechanism of balloon Eustachian tuboplasty: a biomechanical study
Authors: Smith Matthew E. , Weir Anna E. , Prior Daisy C.C. , Cope Wei , Tysome James R. , Sutcliffe Michael 
Published: January 2020

AbstractObstructive Eustachian tube dysfunction (OETD) is a common condition resulting from inadequate opening of the Eustachian tube (ET). A new surgical treatment involves high-pressure inflation of a balloon within the ET, with the aim of dilating the soft tissue structure. However, the mechanical effects of this intervention have not been established, nor the impact of changing device size or other technical parameters. A novel experimental technique allowed quantification of plastic and elastic tissue deformation in model materials and then human cadaver ETs during balloon dilation, based on the measured balloon inflation pressure-volume relationship. Plastic tissue deformation was found to be greater using larger balloons and deeper device insertion, but increasing the inflation pressure had a more limited effect, with most deformation occurring well below the clinically used pressures. Histological assessment of ET tissue suggested that mucosal tearing and cartilage cracking were in part responsible for the mechanical changes. Balloon dilation of the ET has huge potential if found to be clinically effective, but currently there is a need to understand and develop the technique further. The novel methods employed in this study will be valuable in future laboratory and in vivo studies of ET balloon dilation. Pressures are reported in Bar as this unit is used for medical balloon dilation procedures in clinical practice. 1 Bar = 100,000 Pa.
Experience on Using Thoracoscope in Diagnosis and Treatment of Neonatal Idiopathic Esophageal Perforation
Authors: Fan Wei , Huang Jinshi 
Published: January 2020

AbstractIdiopathic esophageal perforation in the neonatal is a rare entity. The presentation is usually with mediastinal inflammation, icherrhemia, and infectious shock, all of which are potentially life-threatening. We present a case with an unusual right side pneumothorax chest and esophagography suggesting an esophageal perforation. With thoracoscope, the esophageal perforation was sutured. The child recovered well from the procedure.
The Absorb bioresorbable vascular scaffold in real-world practice: long-term follow-up of the AMC Single Centre Real World PCI Registry
Authors: Tijssen R. Y. G. , Annink M. E. , Kraak R. P. , Koch K. T. , Baan Jr J. , Vis M. M. , Piek J. J. , Henriques J. P. S. , de Winter R. J. , Beijk M. A. M. , Wykrzykowska J. J. 
Published: January 2020

Abstract
Background
Bioresorbable scaffolds have been introduced to overcome the shortcomings of drug-eluting stents. Higher rates of device thrombosis, however, have been reported up to 3 years after implantation of the Absorb bioresorbable vascular scaffold (BVS). In the current article, we therefore report long-term clinical outcomes of the AMC Absorb Registry.

Methods and results
In the AMC Absorb Registry, all patients who underwent a percutaneous coronary intervention with Absorb BVS implantation between 30 August 2012 and 5 August 2013 at the Amsterdam University Medical Centre—Academic Medical Centre were included. The composite endpoint of this analysis was target-vessel failure (TVF). The median follow-up of the study cohort of the AMC Absorb Registry was 1534 days. At the time of the cross-sectional data sweep the clinical status at 4 years was known in 124 of 135 patients (91.9%). At long-term follow-up, the composite endpoint of TVF had occurred in 27 patients. The 4‑year Kaplan-Meier estimate of TVF was 19.8%. At 4 years cardiac death had occurred in 4 patients (3.2%) and target-vessel myocardial infarction in 9 (6.9%) patients. Definite scaffold thrombosis occurred in 5 (3.8%) patients. We found 1 case of very late scaffold thrombosis that occurred at 911 days after device implantation in a patient who was not on dual anti-platelet therapy.

Conclusion
In a patient population reflecting routine clinical practice, we found that cases of TVF continued to accrue beyond 2 years after Absorb BVS implantation.
Support, technology and mental health: correlates of trainee workplace satisfaction
Authors: Stan Vanessa A. , Correa Ricardo , Deslauriers Jessica R. , Faynboym Semyon , Shah Tina , Widge Alik S. 
Published: January 2020

Introduction Low physician workplace satisfaction may negatively impact patient care. Dissatisfaction may begin during residency training, where trainees face lower autonomy and less control over work conditions. The theoretical and empirical literature on trainees is couched mainly in terms of burnout. Theories of satisfaction, a different construct, are derived from studies of independent physicians. Identifying specific correlates of trainee satisfaction may be a clearer path to preparing a sustainable physician workforce.
Methods We surveyed 3300 residents and fellows (response rate of 7.2% to 46,574 surveys sent) across multiple specialties and institutions in the US. The instrument was adapted from a previous large-scale survey of physician satisfaction, with changes reflecting factors theorized to specifically affect trainee satisfaction. We applied generalized linear regression to identify correlates of higher satisfaction.
Results A total of 1444 (44%) residents/fellows reported they were very satisfied and 1311 (40%) reported being somewhat satisfied. Factors associated with satisfaction included positive perceptions of supporting clinical staff, the electronic health record, and stability of personal mental health. Surprisingly, a strong negative perception of completing insurance and/or disability forms was also associated with higher satisfaction. Factors often presumed to correlate with satisfaction, such as duty hours, debt load, and specialty, did not show significant associations.
Discussion Multiple workplace factors are correlated with trainee satisfaction, but they are not the factors (such as financial debt) that we initially hypothesized.
The do’s, don’ts and don’t knows of establishing a&nbsp;sustainable longitudinal integrated clerkship
Authors: Bartlett Maggie , Couper Ian , Ann Poncelet Ann , Paul Worley Paul 
Published: January 2020

Introduction The longitudinal integrated clerkship is a model of clinical medical education that is increasingly employed by medical schools around the world. These guidelines are a result of a narrative review of the literature which considered the question of how to maximize the sustainability of a new longitudinal integrated clerkship program. Method All four authors have practical experience of establishing longitudinal integrated clerkship programs. Each author individually constructed their Do’s, Don’ts and Don’t Knows and the literature that underpinned them. The lists were compiled and revised in discussion and a final set of guidelines was agreed. A statement of the strength of the evidence is included for each guideline. Results The final set of 18 Do’s, Don’ts and Don’t Knows is presented with an appraisal of the evidence for each one. Conclusion Implementing a longitudinal integrated clerkship is a complex process requiring the involvement of a wide group of stakeholders in both hospitals and communities. The complexity of the change management processes requires careful and sustained attention, with a particular focus on the outcomes of the programs for students and the communities in which they learn. Effective and consistent leadership and adequate resourcing are important. There is a need to select teaching sites carefully, involve students and faculty in allocation of students to sites and support students and faculty though the implementation phase and beyond. Work is needed to address the Don’t Knows, in particular the question of how cost-effectiveness is best measured.