bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural empowerment and serving culture as determinants of organizational identification and turnover intention
Authors: Nowak Radoslaw 
Published: August 2020

PurposeThis paper aims to provide an alternative explanation for how organizations could increase levels of organizational identification, in turn reducing employee turnover intention. Specifically, the study empirically tests the joint effect of two types of organizational resources – structural empowerment and serving culture (SE*SC) – on employee identification. Moreover, it investigates the mediating effect of organizational identification on the relationship between the joint effect (SE*SC) and turnover intention.Design/methodology/approachThe data were collected in 2018 from employees working in a higher education institution located in the USA. Structural equation modeling was used to test the proposed model.FindingsStatistical analysis reveals the positive joint effect (SE*SC) on organizational identification and the mediating effect of identification on the relationship between the joint effect (SE*SC) and turnover intention.Originality/valueThis study contributes to past research by revealing a new important mechanism. Business organizations could increase levels of employee identification and, in turn, reduce turnover by providing empowering resources that allow employees to successfully complete their jobs. Moreover, the study also contributes to practice by providing some recommendations that managers may implement to improve internal effectiveness in their respective organizations.
Top managers’ formal and informal control practices in product innovation processes
Authors: Pan Fagerlin Wen , Lövstål Eva 
Published: August 2020

Purpose
This study aims to understand the formal and informal practices of top managers as they seek to control product innovation processes and how the style of control used differs during development stages and gates.

Design/methodology/approach
A qualitative in-depth case study was conducted at a multinational corporation (pseudonym: MEC). The authors examined 12 product innovation projects and carried out semi-structured interviews to understand the experiences, perceptions and challenges of the people involved in product development projects with a focus on the interactions between top managers and the project teams.

Findings
The authors found that MEC uses formal control mechanisms such as a stage-gate model and a project management and reporting system to keep track of the progress of innovation projects. In addition, top managers use informal controls through involvement in innovation activities and interaction with the team members during the stages and gates of the development process. To carry out their control practices top managers use four distinct styles of control as follows: participative, facilitative, empowering and authoritative.

Practical implications
Suggestions are provided for managers on how formal and informal management control tools can be used in innovation processes. The authors show how top managers can broaden their range of interventions by involving themselves in product innovation projects in different ways.

Originality/value
This paper shows how the combination of formal and informal controls can generate a more holistic view of management control in innovation. It also adds to previous conceptualizations of control use by suggesting four distinct styles, which top managers can use to involve themselves in product innovation processes.
The intestinal microbiome of an Indo‐Pacific humpback dolphin (Sousa chinensis) stranded near the Pearl River Estuary, China
Authors: WAN Xiaoling , LI Jia , CHENG Zhaolong , AO Mengxue , TIAN Renmao , MCLAUGHLIN Richard William , ZHENG Jinsong , WANG Ding 
Published: August 2020

AbstractThe mammalian intestinal microbiome is critical for host health and disease resistance. However, the cetacean intestinal microbiota remains relatively unexplored. By using high‐throughput 16S rRNA gene sequencing, we analyzed intestinal bacterial samples from an Indo‐pacific humpback dolphin (Sousa chinensis) stranded near the Pearl River Estuary in China. The samples included 3 anatomical regions (foregut, midgut, and rectum) and 2 anatomical locations (content and mucus). Our analyses revealed that the dolphin intestinal bacteria contained 139 operational taxonomic units (OTUs), dominated at the phyla level by Firmicutes (47.05% in the content; 94.77% in the mucus), followed by Bacteroidetes (23.63% in the content; 1.58% in the mucus) and Gammaproteobacteria (14.82% in the content; 2.05% in the mucus). The intestinal bacteria had a small core community (15 OTUs, accounting for 99.74% of the reads), some of which could be potentially pathogenic to both human and dolphins. As an alternative to sampling the dolphin intestinal bacteria, fecal sampling could be used. Additionally, function potentials such as, xenobiotics biodegradation, beta‐lactam resistance, and human disease‐related pathways, were detected in the dolphin intestinal bacteria. These findings provide the first baseline knowledge of the intestinal microbiome of the Indo‐Pacific humpback dolphin, which may offer new insights into cetacean conservation by using microbial surveillance.
Endocrine correlates of gender and throat coloration in the southern ground‐hornbill (Bucorvus leadbeateri)
Authors: SCHEUN Juan , NELLER Sophie , BENNETT Nigel C. , KEMP Lucy V. , GANSWINDT Andre 
Published: August 2020

AbstractThe southern ground‐hornbill (SGH) is a cooperatively breeding bird endemic to eastern and southern Africa, but is endangered in its southern distributional range. The national conservation restoration program harvests redundant chicks for captive breeding and reintroduction; with sexing and social grouping of the species evaluated by throat‐skin coloration, with adult males displaying a completely red color compared to dark blue within the red observed in adult females. However, recent findings indicate that dominant and subordinate adult males exhibit patches of blue throat‐skin. To optimize SGH management practices, it is vital to determine the role of red and blue coloration, as well as the possible drivers thereof. As a prerequisite, an enzyme immunoassay for monitoring fecal androgen metabolite (fAM) concentrations in SGH was established. Following this, fresh fecal samples were collected from 78 SGH, of various demographics and origin, across 12 captive institutions, to determine whether fAM concentrations differ between blue (B), partially blue (sB), and fully red (R) throat‐skin colored SGH. Furthermore, fAM concentrations were compared between males housed in different social groups of different age and sex classes. Individual median fAM concentrations of B, sB, and R adult males did not differ significantly but were considerably higher in B and sB males compared to R males. Social dynamics within captivity, for example, dominance, played no role as a driver of male gonadal activity or throat skin coloration. The results of the study indicate that androgens and apparent social dynamics are not primary determinants of throat coloration in male SGH.
Psoriatic arthritis: A systematic review of non‐HLA genetic studies and important signaling pathways
Authors: Chen Jingjing , Yuan Feng , Fan Xing , Wang Yahua 
Published: August 2020

AbstractPsoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non‐human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases National Center for Biotechnology Information, Google and PubMed, 37 articles are included and 50 susceptibility non‐HLA genes for PsA are presented, such as IL23A, TNIP1, TYK2, STAT4, IL12B, RUNX3 and TRAF3IP2. In these non‐HLA genes, some are common genes shared with other diseases, whereas most of these susceptibility genes are related to the pathogenesis of PsA by activation or inhibition of the signaling pathways. Several signaling pathways possibly implicated in the pathogenesis of PsA are introduced in this paper, including the 2 mainly signaling pathways, IL23/Th17 signaling pathway and NF‐κB signaling pathway, and the other involved signaling pathways, such as JAK‐STAT signaling pathway and MAPK signaling pathway.
GFRα‐1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini‐review
Authors: Zhang Xue‐Ming 
Published: August 2020

AbstractIdentification of the specific biomarkers is of great importance to enrich and expand the gonocytes or spermatogonial stem cells (SSCs) in livestock. The glial cell line‐derived neurotrophic factor (GDNF) family receptor alpha‐1 (GFRα‐1) is a conserved marker of the gonocytes/SSCs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/SSCs is debated. Recently, we and other teams clearly demonstrated the expression of GFRα‐1 in bovine gonocytes/SSCs. This is useful for bovine gonocytes/SSCs‐related research or application. Nonetheless, new methods still need to be developed to identify the undifferentiated spermatogonial subsets in large livestock and elucidate their spermatogenic potency.
Detection of mosaicism for segmental and whole chromosome imbalances by targeted sequencing
Authors: Villela Darine , de Barros Juliana Sobral , da Costa Silvia Souza , Aguiar Talita F. M. , Campagnari Francine , Vianna‐Morgante Angela M. , Krepischi Ana C. V. , Rosenberg Carla 
Published: August 2020

AbstractMosaic segmental and whole chromosome copy number alterations are postzygotic variations known to be associated with several disorders. We have previously presented an efficient targeted sequencing approach to simultaneously detect point mutations and copy number variations (CNVs). In this study, we evaluated the efficiency of this approach to detect mosaic CNVs, using seven postnatal and 19 tumor samples, previously characterized by chromosomal microarray analyses (CMA). These samples harbored a total of 28 genomic imbalances ranging in size from 0.68 to 171 Mb, and present in 10–80% of the cells. All CNV regions covered by the platform were correctly identified in postnatal samples, and only seven out of 19 CNVs from tumor samples were not identified either because of a lack of target probes in the affected genomic regions or an absence of minimum reads for an alteration call. These results demonstrate that, in a research setting, this is a robust approach for detecting mosaicism in cases of segmental and whole chromosome alterations. Although the current sequencing platform presented a resolution similar to genomic microarrays, it is still necessary to further validate this approach in a clinical setting in order to replace CMA and sequencing analyses by a single test.
Rosacea and the gastrointestinal system
Authors: Searle Tamara , Ali Faisal R. , Carolides Sarah , Al‐Niaimi Firas 
Published: August 2020

AbstractRosacea is a common skin condition characterised by erythema, papules and pustules. Increasing evidence suggests that the gut–skin axis is implicated in the pathogenesis of rosacea. Sufficient evidence exists to support the notion that the gut microbiome plays a role in the inflammatory cutaneous response and there appear to be associations with small intestinal bacterial overgrowth and Helicobacter pylori infection. A dysbiotic microbiome and an innate immune system dysregulation contribute to the pathophysiology of rosacea, and further exploration of their roles is warranted. Greater understanding of this condition and the effect of the gut–skin axis could allow for more efficacious and timely treatment. This article reviews our current findings and understanding in the skin and gut relationship in rosacea.
Morphological, ultrastructural and immunohistochemical study on the skin ventral photophores of Diaphus holti Tåning, 1918 (Family: Myctophidae)
Authors: Cavallaro Mauro , Guerrera Maria Cristina , Abbate Francesco , Levanti Maria Beatrice , Laurà Rosaria , Ammendolia Giovanni , Malara Danilo , Stipa Maria Giulia , Battaglia Pietro 
Published: August 2020

AbstractA further contribution to the knowledge of the photophore structure of the mesopelagic fish Diaphus holti (Myctophidae) from the central Mediterranean Sea (Strait of Messina) is given by means of a structural, ultrastructural and immunohistochemical study, to describe the component structures of these luminescent organs.
Leveraging personality information to improve community recommendation in e‐learning platforms
Authors: Sun Jianshan , Geng Jie , Cheng Xusen , Zhu Mingyue , Xu Qiyu , Liu Yunli 
Published: August 2020

AbstractE‐learning platforms are becoming more and more important and they are gradually changing people’s learning ways. In the e‐learning platforms, users actively create and join their favorite communities to share their questions and ideas. With the increase of users of e‐learning platforms, the number of communities is increasing dramatically. In this context, it has become difficult for users to find learning communities that match their interests and preferences. Therefore, how to effectively recommend the learning community for users has become an urgent need. However, compared to learning item recommendation, there is relatively limited work on learning community recommendation, and the existing research on community recommendation often ignores the personality information. Personality is considered one of the primary factors that influence human behavior and social relationships, as it affects how people react and interact with others. Several studies have demonstrated that people with similar personality tend to have similar interests. Furthermore, homophily theory also states that social interactions between similar individuals occur at a higher rate than among dissimilar ones. Since interests and interactions are important driving forces for users to join the learning communities, personality has an important impact on users’ choices of communities. Therefore, this paper aims at shedding some light on the impact of personality information on the accuracy of community recommendations. Particularly, we propose three enhanced matrix factorization models based on the Big Five personality framework. To evaluate the effectiveness of our proposed models, we conducted extensive experiments on myPersonality datasets. The results prove that the personality information can improve the performance of the learning community recommendation model and alleviate the data sparsity problem.
Plasma membrane to vacuole traffic induced by glucose starvation requires Gga2‐dependent sorting at the trans‐Golgi network
Authors: Buelto Destiney , Hung Chao‐Wei , Aoh Quyen L. , Lahiri Sagar , Duncan Mara C. 
Published: August 2020

Background InformationIn the yeast Saccharomyces cerevisiae, acute glucose starvation induces rapid endocytosis followed by vacuolar degradation of many plasma membrane proteins. This process is essential for cell viability, but the regulatory mechanisms that control it remain poorly understood. Under normal growth conditions, a major regulatory decision for endocytic cargo occurs at the trans‐Golgi network (TGN) where proteins can recycle back to the plasma membrane or can be recognized by TGN‐localised clathrin adaptors that direct them towards the vacuole. However, glucose starvation reduces recycling and alters the localization and post‐translational modification of TGN‐localised clathrin adaptors. This raises the possibility that during glucose starvation endocytosed proteins are routed to the vacuole by a novel mechanism that bypasses the TGN or does not require TGN‐localised clathrin adaptors.ResultsHere, we investigate the role of TGN‐localised clathrin adaptors in the traffic of several amino acid permeases, including Can1, during glucose starvation. We find that Can1 transits through the TGN after endocytosis in both starved and normal conditions. Can1 and other amino acid permeases require TGN‐localised clathrin adaptors for maximal delivery to the vacuole. Furthermore, these permeases are actively sorted to the vacuole, because ectopically forced de‐ubiquitination at the TGN results in the recycling of the Tat1 permase in starved cells. Finally, we report that the Mup1 permease requires the clathrin adaptor Gga2 for vacuolar delivery. In contrast, the clathrin adaptor protein complex AP‐1 plays a minor role, potentially in retaining permeases in the TGN, but it is otherwise dispensable for vacuolar delivery.Conclusions and significanceThis work elucidates one membrane trafficking pathway needed for yeast to respond to acute glucose starvation. It also reveals the functions of TGNlocalised clathrin adaptors in this process. Our results indicate that the same machinery is needed for vacuolar protein sorting at the GN in glucose starved cells as is needed in the presence of glucose. In addition, our findings provide further support for the model that the TGN is a transit point for many endocytosed proteins, and that Gga2 and AP‐1 function in distinct pathways at the TGN.
Sigma 1 receptor as a therapeutic target for amyotrophic lateral sclerosis
Authors: Herrando‐Grabulosa Mireia , Gaja‐Capdevila Núria , Vela José M. , Navarro Xavier 
Published: August 2020

Amyotrophic lateral sclerosis (ALS) is an adult disease causing a progressive loss of upper and lower motoneurons, muscle paralysis and early death. ALS has a poor prognosis of 3–5 years after diagnosis with no effective cure. The aetiopathogenic mechanisms involved include glutamate excitotoxicity, oxidative stress, protein misfolding, mitochondrial alterations, disrupted axonal transport and inflammation. Sigma non‐opioid intracellular receptor 1 (sigma 1 receptor) is a protein expressed in motoneurons, mainly found in the endoplasmic reticulum (ER) on the mitochondria‐associated ER membrane (MAM) or in close contact with cholinergic postsynaptic sites. MAMs are sites that allow the assembly of several complexes implicated in essential survival cell functions. The sigma 1 receptor modulates essential mechanisms for motoneuron survival including excitotoxicity, calcium homeostasis, ER stress and mitochondrial dysfunction. This review updates sigma 1 receptor mechanisms and its alterations in ALS, focusing on MAM modulation, which may constitute a novel target for therapeutic strategies.LINKED ARTICLESThis article is part of a themed issue on Recent advances in ALS pathogenesis and therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.6/issuetoc
Production of Inflected Novel Words in Older Adults With and Without Dementia
Authors: Nikolaev Alexandre , Higby Eve , Hyun JungMoon , Lehtonen Minna , Ashaie Sameer , Hallikainen Merja , Hänninen Tuomo , Soininen Hilkka 
Published: August 2020

AbstractWhile cognitive changes in aging and neurodegenerative disease have been widely studied, language changes in these populations are less well understood. Inflecting novel words in a language with complex inflectional paradigms provides a good opportunity to observe how language processes change in normal and abnormal aging. Studies of language acquisition suggest that children inflect novel words based on their phonological similarity to real words they already know. It is unclear whether speakers continue to use the same strategy when encountering novel words throughout the lifespan or whether adult speakers apply symbolic rules. We administered a simple speech elicitation task involving Finnish‐conforming pseudo‐words and real Finnish words to healthy older adults, individuals with mild cognitive impairment, and individuals with Alzheimer's disease (AD) to investigate inflectional choices in these groups and how linguistic variables and disease severity predict inflection patterns. Phonological resemblance of novel words to both a regular and an irregular inflectional type, as well as bigram frequency of the novel words, significantly influenced participants' inflectional choices for novel words among the healthy elderly group and people with AD. The results support theories of inflection by phonological analogy (single‐route models) and contradict theories advocating for formal symbolic rules (dual‐route models).
Profile of hospital transplant ethics committees in the Philippines
Authors: Abacan Mary Ann 
Published: August 2020

AbstractIn the Philippines, all transplant centers are mandated by the Department of Health (DOH) to have a Hospital Transplant Ethics Committee (HTEC) to ensure that donations are altruistic, voluntary and free of coercion/commercial transactions. This study was undertaken primarily to describe the organizational and functional profile of existing HTECs and identify areas for improvement. This is a descriptive cross‐sectional study. There was variation in their logistical arrangements (support from hospital, filing systems, office spaces), operations (length and frequency of meetings, number of referrals) and membership (composition, qualifications, occupation, training). The approval rate for donor‐recipient pairs is high with the majority of cases made by living non‐related donors. Appropriate reasons were cited for rejection. The perception of HTECs is that they are competent and confident in their decision‐making. However, there is a need to standardize HTEC composition, provide operating procedures and additional training which can be done by the DOH.
Reduced incidence of type 2 diabetes in patients with chronic hepatitis C virus infection cleared by direct‐acting antiviral therapy: A prospective study
Authors: Adinolfi Luigi E. , Petta Salvatore , Fracanzani Anna L. , Nevola Riccardo , Coppola Carmine , Narciso Vincenzo , Rinaldi Luca , Calvaruso Vincenza , Pafundi Pia Clara , Lombardi Rosa , Staiano Laura , Di Marco Vito , Solano Antonio , Marrone Aldo , Saturnino Mariarosaria , Rini Francesca , Guerrera Barbara , Troina Graziano , Giordano Mauro , Craxì Antonio , Sasso Ferdinando C. 
Published: August 2020

AbstractAimTo assess the effect of hepatitis C virus (HCV) eradication on type 2 diabetes mellitus (T2DM). incidence.MethodsA prospective multicentre case–control study was performed, which included 2426 patients with HCV, 42% of whom had liver fibrosis stage F0‐F2 and 58% of whom had liver fibrosis stage F3‐F4. The study population consisted of a control group including 1099 untreated patients and 1327 cases treated with direct‐acting antivirals (DAAs). T2DM incidence was assessed during a median (interquartile range) follow‐up period of 30 (28–42) months. Risk factors for T2DM were assessed using a Cox regression model (relative risk [RR], hazard ratio [HR], Kaplan–Meier analysis). Insulin sensitivity was evaluated by homeostatic model assessment (HOMA) and changes by repeated‐measures ANOVA. Factors independently associated with T2DM were assessed by multivariate analysis.ResultsThe absolute incidence of T2DM for controls and cases was 28 and 7/1000 person‐years, respectively (P = 0.001). In cases compared to controls, HCV clearance reduced the RR and HR of T2DM by 81% and 75% to 93%, respectively (P = 0.001). It was calculated that, for every 15 patients who obtained HCV clearance, one case of T2DM was saved. HCV clearance was associated with significant reductions in HOMA‐insulin resistance and HOMA‐β‐cell function and an increase in HOMA‐insulin sensitivity, as assessed in 384 patients before and after HCV clearance. At multivariate analysis, HCV clearance emerged as independently associated with a reduced T2DM risk.ConclusionThe results showed that HCV clearance by DAA treatment reduces T2DM incidence probably by restoring the HCV‐induced alteration of glucose homeostasis mechanisms.