bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cracking Control in Mezzanine Floor Slabs using Rice Husk Ash and Polypropylene Fibers
Authors: Cano B , Galarza J , Rodríguez J , García F 
Published: February 2020

AbstractThe continuous population increase in recent years requires a greater number of households to be built quickly, with good materials and produced under quality standards that guarantee their manufacturing process. The prefabricated concrete, produced and supplied by concrete plants, is poured into the different structural elements, the mezzanine slabs being the most careful surfaces in the appearance of fissures; because being horizontal and having larger dimensions, the dimensional changes in the concrete appear more frequently due to the rapid loss of water from the surface of the concrete before setting; which generates superior stresses to the resistant capacity of the concrete at early ages, which affect the durability and reduce the resistance of the structures, causing greater economic expenses in maintenance and repairs. In the present investigation, 5%, 10% and 15% of rice husk ash was used as a replacement for cement and 900g/m3of polypropylene fiber; The results indicate that as the percentage of rice husk ash increases, there is a reduction in the slump and the crack fissures, and that the resistance to compression and flexion decreases, with respect to the concrete pattern.
Wavy water thin-film characteristics on horizontal plate using PLIF Experimental
Authors: Moustafa Mohamed , Ruifeng Tian , Emam Islam S. 
Published: February 2020

Abstract
Nonlinear Thin liquid film is commonly applied in numerous engineering fields, including the Passive Containment Cooling System of the nuclear power plant and steam dryer in the steam generator of nuclear power plants. The counter gas flow effect through a rectangular channel was inspected, the flow is motivated by the pressure gradient and shear gas stress while the gravity force does not influence the flow. Different flow rates of gas were set to different Reynolds numbers from 6950 to 34800 with influence on a different range of input water Reynolds number from 170 to 875 respectively. The data was collected at different sections from inlet flow until the separation section. The thickness of liquid film investigated using (PLIF) experiments. The thickness has been calculated via digital image processing and MATLAB code. Film thickness was obtained as a function of time and frequency. Results were analyzed using statistic tools such as property density function (PDF), fast Fourier transform (FFT), and power spectral density (PSD).
Numerical analysis and Experimental Investigation of Lateral vibration on Drill String under Axial Load Constrained with Horizontal Pipe
Authors: Wang Baojin , Wang Zhongyang , Zhu Anhe , Hongda Wang , Ren Fushen 
Published: February 2020

Abstract
Horizontal well technology is an important means to improve drilling efficiency and oil and gas production, but it is easy to generate the lateral vibration of the drill string. This strong lateral vibration of the drill string will further lead to the whirl of the drill string, which will accelerate the wear of the drill string and further lead to the failure of the drill string. According to the rotor dynamics theory and fluid dynamics, the whirling equation of the drill string in horizontal wells is established. The effects of the weight of the drill string, wall friction, internal and external drilling fluid flow velocity and fluid resistance on the whirling of the drill string are studied. The mechanism of inducing the whirling of the horizontal drill string and the boundary conditions for judging the whirling are analyzed. Based on the existing dynamic simulation test equipment of the horizontal drill string in the laboratory, the experimental research on the whirling characteristics of the horizontal drill string is carried out, and the influence laws of the weight on bit and the rotation speed on the whirling of the drill string are studied. The results show that with the development of axial load, the intense of lateral vibration of drill string increases.
Comprehensive Planning of New Plant Under Industry 4.0
Authors: Tiefeng Zhang , Yifei Tong , Yuanhao Zhang , Xu Zhang 
Published: February 2020

Abstract
The article carries out layout design optimization and warehouse improvement for HF Company. First of all, taking the production management process of the new plant as the research object, set a comprehensive planning of the plant area from the aspects of product mix, production management and logistics management. According to the planning objectives, detailed design, data collection for production forecasting are proposed based on SLP method and mapping of the new plant layout, combined with lean thinking and Industry 4.0 concept. Finally, the expected goals and improve production efficiency are achieved.
Post-cracking Poisson Ratio of Concrete in Steel-Concrete-Steel Panels Subjected to Biaxial Tension Compression
Authors: Prasad Manish , XiaoBing Song 
Published: February 2020

Abstract
Consideration of post-cracking Poisson ratio of concrete is found significant in predicting the behavior of Steel-Concrete-Steel (SCS) panels under biaxial tension compression. Concrete reinforced with face steel plates was found to be under confinement which deviates the established nature of the post-cracking Poisson ratio. In order to account for such confinement, an extension to previously proposed expression for the Poisson effect in reinforced concrete (RC) is presented in this paper to be used for the analysis of SCS in which the reinforcing elements, steel plates, provide confinement in the principle tensile direction. A tri-linear model is proposed for the Poisson ratio and then compared with the experimental results.
Seismic Effect Analysis of the Adjacent Longitudinal Box Culvert for the Utility Tunnel
Authors: Gebremedhn Zenagebriel , Qiao Guofu , Sun Lu 
Published: February 2020

Abstract
The utility tunnel has the vital significance of the underground public facilities construction for the modernized urban construction inevitable trend. The traditional utility tunnel was used as one of the approaches to achieve sustainable developments. The whole energy supply and distribution system in china will need to be restructured and reworked. Thus, there is still a limited research available on the seismic effect of the utility tunnel. So that, this paper aims to fulfil this research need by investigating the FEA of the adjacent longitudinal box culvert for the utility tunnel is deployed under the circumstance of seismic effect through ABAQUS software concerning to Amplitude A, B and C with time period of 53.47sec, 53.73sec and 53.79sec. The result indicates that, the seismic stress of the box culvert specifically the box culvert including certain soil parts with seismic time and load were found grey zone which is needed greatest warning zone before failure. Finally, the displacement time-history are then studied in the paper which meets the requirements duration from 10 to 20 times. The displacement change is caused by the subsidence of the soil foundation due to the displacement values on the corresponding corner points are much different.
Experimental and Theoretical Investigation of Nonlinear Dynamic characteristics in an Oil-free Moving Coil Linear Compressor
Authors: Sun Jian , Li Chengzhan , Li Jianguo , Cai Jinghui 
Published: February 2020

Abstract
The gas pressure, piston displacement and current response characteristics of an oil-free moving coil linear compressor driven by sinusoidal voltages at different frequencies have been experimentally studied. The results show that the response curves of gas pressure, piston displacement and current have nonlinear distortions deviating from the sinusoidal waveform. Among them, the piston displacement waveform has relatively small deviation from sinusoid, and the total harmonic distortion rate (THD) of piston displacement has a maximum value of 6.2% at 50Hz; the current waveform has relatively large deviation from sinusoid, and the THD of current has a maximum value of 73.7% at 60Hz. At this time, the current has two peaks in one cycle. It was analyzed that the nonlinear distortion of displacement and current occurs only in the compression process in a working cycle. In addition, a nonlinear dynamic model based on MATLAB software was established to analyze current distortion. The simulated values of gas pressure, piston displacement and current curves have a good coincidence with measured values. Finally, it is present that the severe distortion of the current curve is mainly caused by the non-linearity of the gas pressure.
Proposal of Flowable Fill Designs for improvement of excavation and filling works of trenches in sanitation systems
Authors: Cruz J , Ñiquin J , Bragagnini I , Sotomayor C 
Published: February 2020

Abstract
Population grow in recent years requires an extension of the current pipeline sanitary system. For this purpose, granular excavation and landfill works are associated with pedestrian traffic congestion. Therefore, it is necessary to develop an innovative and sustainable alternative to reduce the problems generated during the execution of the conventional process. This research proposes the use of flowable fill due to the multiple advantages offered by this material. On the one hand, it is economical for medium to large trench fill volumes, considering savings in labor (it is done with a small number of workers), in equipment (does not require the rental or purchase of compaction equipment) and in time (the pouring is done by directly pumping the mixture, from the mixing machines to the excavation). On the other hand, being self-compacting and self-leveling decreases the width of the trenches, reducing excavation and filling volumes; which, in turn, incur money savings. Also, this material guarantees work safety, since people are not required inside the excavation and fill in poorly accessible areas without any problem. Dosages were established for ten flowable fill mixtures with cement contents of 50, 60, 70, 80 and 90 kg of cement and a range of admixture from 1.75 to 2.00%; The results indicated that decreasing the fine aggregate - coarse aggregate ratio, the compressive strength of the mixtures increases and the slumps of the mixtures decreases, and the compressive strength increases directly proportional to the cement content.
Effects of Steel Bracings in the Progressive Collapse Resistance of Reinforced Concrete Building
Authors: Shah Bikram , Xu Feng 
Published: February 2020

Abstract
The bracing system used in the seismic retrofitting can also be used as a measure to resist the progressive collapse of the multi-storeyed structures. The nonlinear dynamic analysis is used to study the effects of floor wise and bay wise bracing systems in the progressive collapse resistance of seismic designed reinforced concrete buildings. The numerical model is created in SAP2000 and is analysed for three different column removal scenarios using UFC guidelines. The results showed the significant contribution of the bracing system to prevent the progressive collapse due to single removed column. The bay wise bracing system is more effective to reduce the deformations but there is no contribution of the bracings when the column is removed from the non-adjacent bay. The floor wise bracing is more reliable than bay wise bracings.
Low Permeability Concrete for Buildings Located in Marine Atmosphere Zone using Clay Brick Powder
Authors: Castillo M , Hernández K , Rodriguez J , Eyzaguirre C 
Published: February 2020

Abstract
The concrete is not one hundred percent impermeable since the water that remains inside it causes its corrosion, in the case of reinforced concrete, exposed in an area of marine atmosphere, the sea salt mostly present in large particles of the marine spray, produce the reduction of the alkalinity of the concrete causing a rapid corrosion of the steel. There are buildings built in this marine area that have been designed without durability criteria, in which the use of pozzolanic materials is considered, for example, to fill the pores of the cement matrix and thus guarantee its impermeability. In the present study, the effect of clay brick powder (PLA) as a replacement for cement in concrete manufacturing is addressed, evaluating different characteristics of its components. The results indicate that pozzolanic activity and compressive strength increase, slump, voids content and the coefficient of permeability to water decreases.
Small regulatory noncoding RNAs in Drosophila melanogaster: biogenesis and biological functions
Authors: Soleimani Saeed , Valizadeh Arshad Zahra , Moradi Sharif , Ahmadi Ali , Davarpanah Seyed Javad , Azimzadeh Jamalkandi Sadegh 
Published: February 2020

AbstractRNA interference (RNAi) is an important phenomenon that has diverse genetic regulatory functions at the pre- and posttranscriptional levels. The major trigger for the RNAi pathway is double-stranded RNA (dsRNA). dsRNA is processed to generate various types of major small noncoding RNAs (ncRNAs) that include microRNAs (miRNAs), small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) in Drosophila melanogaster (D. melanogaster). Functionally, these small ncRNAs play critical roles in virtually all biological systems and developmental pathways. Identification and processing of dsRNAs and activation of RNAi machinery are the three major academic interests that surround RNAi research. Mechanistically, some of the important biological functions of RNAi are achieved through: (i) supporting genomic stability via degradation of foreign viral genomes; (ii) suppressing the movement of transposable elements and, most importantly, (iii) post-transcriptional regulation of gene expression by miRNAs that contribute to regulation of epigenetic modifications such as heterochromatin formation and genome imprinting. Here, we review various routes of small ncRNA biogenesis, as well as different RNAi-mediated pathways in D. melanogaster with a particular focus on signaling pathways. In addition, a critical discussion of the most relevant and latest findings that concern the significant contribution of small ncRNAs to the regulation of D. melanogaster physiology and pathophysiology is presented.
Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease
Authors: Gruenenfelder Fredrik I , McLaughlin Mark , Griffiths Ian R , Garbern James , Thomson Gemma , Kuzman Peter , Barrie Jennifer A , McCulloch Maj-lis , Penderis Jacques , Stassart Ruth , Nave Klaus-Armin , Edgar Julia M 
Published: February 2020

Abstract
Pelizaeus-Merzbacher disease is a fatal X-linked leukodystrophy caused by mutations in the PLP1 gene, which is expressed in the CNS by oligodendrocytes. Disease onset, symptoms and mortality span a broad spectrum depending on the nature of the mutation and thus the degree of CNS hypomyelination. In the absence of an effective treatment, direct cell transplantation into the CNS to restore myelin has been tested in animal models of severe forms of the disease with failure of developmental myelination, and more recently, in severely affected patients with early disease onset due to point mutations in the PLP1 gene, and absence of myelin by MRI. In patients with a PLP1 duplication mutation, the most common cause of Pelizaeus-Merzbacher disease, the pathology is poorly defined because of a paucity of autopsy material. To address this, we examined two elderly patients with duplication of PLP1 in whom the overall syndrome, including end-stage pathology, indicated a complex disease involving dysmyelination, demyelination and axonal degeneration. Using the corresponding Plp1 transgenic mouse model, we then tested the capacity of transplanted neural stem cells to restore myelin in the context of PLP overexpression. Although developmental myelination and axonal coverage by endogenous oligodendrocytes was extensive, as assessed using electron microscopy (n = 3 at each of four end points) and immunostaining (n = 3 at each of four end points), wild-type neural precursors, transplanted into the brains of the newborn mutants, were able to effectively compete and replace the defective myelin (n = 2 at each of four end points). These data demonstrate the potential of neural stem cell therapies to restore normal myelination and protect axons in patients with PLP1 gene duplication mutation and further, provide proof of principle for the benefits of stem cell transplantation for other fatal leukodystrophies with ‘normal’ developmental myelination.
TRIM32 Deficiency Impairs Synaptic Plasticity by Excitatory-Inhibitory Imbalance via Notch Pathway
Authors: Ntim Michael , Li Qi-Fa , Zhang Yue , Liu Xiao-Da , Li Na , Sun Hai-Lun , Zhang Xuan , Khan Bakhtawar , Wang Bin , Wu Qiong , Wu Xue-Fei , Walana Williams , Khan Khizar , Ma Quan-Hong , Zhao Jie , Li Shao 
Published: February 2020

Abstract
Synaptic plasticity is the neural basis of physiological processes involved in learning and memory. Tripartite motif-containing 32 (TRIM32) has been found to play many important roles in the brain such as neural stem cell proliferation, neurogenesis, inhibition of nerve proliferation, and apoptosis. TRIM32 has been linked to several nervous system diseases including autism spectrum disorder, depression, anxiety, and Alzheimer’s disease. However, the role of TRIM32 in regulating the mechanism of synaptic plasticity is still unknown. Our electrophysiological studies using hippocampal slices revealed that long-term potentiation of CA1 synapses was impaired in TRIM32 deficient (KO) mice. Further research found that dendritic spines density, AMPA receptors, and synaptic plasticity-related proteins were also reduced. NMDA receptors were upregulated whereas GABA receptors were downregulated in TRIM32 deficient mice, explaining the imbalance in excitatory and inhibitory neurotransmission. This caused overexcitation leading to decreased neuronal numbers in the hippocampus and cortex. In summary, this study provides this maiden evidence on the synaptic plasticity changes of TRIM32 deficiency in the brain and proposes that TRIM32 relates the notch signaling pathway and its related mechanisms contribute to this deficit.
Critical National Shortage of Cefazolin in Japan: Management Strategies
Authors: Honda Hitoshi , Murakami Shutaro , Tokuda Yasuharu , Tagashira Yasuaki , Takamatsu Akane 
Published: February 2020

AbstractThe shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a first-line agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.
Spatiotemporal photosynthetic physiology responses of remnant Myricaria laxiflora populations to regulated water level fluctuations
Authors: Guan Shou-Peng , Chen Fang-Qing , Zhou Ju-Mei , Xie Zong-Qiang , Huang Yong-Wen 
Published: February 2020

Abstract
The construction of the Three Gorges–Gezhouba Dam cascade hydropower station has changed the water level fluctuation pattern of the habitats for remnant rare and endangered Myricaria laxiflora populations downstream of the dam. The present study utilized biochemical markers of photosynthetic physiology to evaluate the spatiotemporal responses of remnant populations to human-regulated water level fluctuations. The results showed that the photosynthetic physiological activities of remnant M. laxiflora populations underwent a period of rapid growth, followed by a gradual decline in the growth recovery phase after flooding. During the entire experimental period, photosynthetic physiological activities of remnant M. laxiflora populations changed with prolongation of emergence time: specifically, net photosynthetic rate and stomatal conductance initially decreased and then subsequently increased, intercellular carbon dioxide concentrations peaked at mid-phase and transpiration rate continuously increased. The maximum net photosynthetic rate, apparent photosynthetic quantum efficiency and dark respiration rate in the light–response curves of the plants continuously increased during growth. The water level gradient also significantly affected the photosynthetic physiological activities in the remnant populations, i.e. the photosynthetic physiological activities of high-altitude plants were significantly higher than the middle- and low-altitude plants. The changes in photosynthetic pigment content of plants in remnant populations during the growth recovery phase and the entire growth period were similar to those occurring in photosynthetic activities in plants. Further, canonical correspondence analysis showed that photosynthetic physiological activities in the plants were significantly correlated with changes in water levels, emergence time, elevation gradient, soil water and soil nitrogen contents. Therefore, the artificial regulation of water level fluctuations by large hydropower stations will inevitably affect the photosynthetic activities and growth of remnant M. laxiflora populations.