bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the impacts of climate change on aerobic rice production using the DSSAT-CERES-Rice model
Authors: Alejo Lanie A. 
Published: June 2020

AbstractThis study assessed the impacts of climate change on aerobic rice production using the DSSAT-CERES-Rice model. Actual data observed from four cropping seasons in two sites were used for calibration and validation. Four Representative Concentration Pathway scenarios were used to simulate climate change. The optimum planting windows were simulated across these scenarios. Results showed that DSSAT-CERES-Rice could adequately simulate aerobic rice production. Changes in seasonal rainfall and increases in temperature especially during dry seasons adversely affected aerobic rice production. Reduction of rainfall during the wet seasons favored aerobic rice production. Yield losses are twice as large as gains. Changes in climate could cause yield improvements to decline from 83% to 53% and yield reductions to increase from 150% to 177% towards the end of the 21st century. Selecting the best planting windows could optimize production to avoid huge economic losses. Optimum planting windows were simulated during normal, dry, and wet climate conditions. The derived set of genetic coefficients could be used to assess various aerobic rice farm crop and nutrient management strategies as well as other climate and soil conditions. The long-term projections on aerobic rice production could guide policy and decision-makers on designing long-term climate change adaptation and mitigation plans and programs.
A Systems Biology Approach for miRNA-mRNA Expression Patterns Analysis in Rheumatoid Arthritis
Authors: Tavasolian Fataneh , Hosseini Ahmad Zavaran , Soudi Sara , Naderi Mahmood , Sahebkar Amirhossein 
Published: June 2020

Objective:
Considering the molecular complexity and heterogeneity of rheumatoid
arthritis (RA), the identification of novel molecular contributors involved in RA initiation and
progression using systems biology approaches will open up potential therapeutic strategies. The
bioinformatics method allows the detection of associated miRNA-mRNA as both therapeutic and
prognostic targets for RA.

Methods:
This research used a system biology approach based on a systematic re-analysis of the
RA-related microarray datasets in the NCBI Gene Expression Omnibus (GEO) database to find out
deregulated miRNAs. We then studied the deregulated miRNA-mRNA using Enrichr and
Molecular Signatures Database (MSigDB) to identify novel RA-related markers followed by an
overview of miRNA-mRNA interaction networks and RA-related pathways.

Results:
This research mainly focused on mRNA and miRNA interactions in all tissues and
blood/serum associated with RA to obtain a comprehensive knowledge of RA. Recent systems
biology approach analyzed seven independent studies and presented important RA-related
deregulated miRNAs (miR-145-5p, miR-146a-5p, miR-155-5p, miR-15a-5p, miR-29c-3p, miR-
103a-3p, miR-125a-5p, miR-125b-5p, miR-218); upregulation of miR-125b is shown in the study
(GSE71600). While the findings of the Enrichr showed cytokine and vitamin D receptor pathways
and inflammatory pathways. Further analysis revealed a negative correlation between the vitamin
D receptor (VDR) and miR-125b in RA-associated gene expression.

Conclusion:
Since vitamin D is capable of regulating the immune homeostasis and decreasing the
autoimmune process through its receptor (VDR), it is regarded as a potential target for RA.
According to the results obtained, a comparative correlation between negative expression of the
vitamin D receptor (VDR) and miR-125b was suggested in RA. The increasing miR-125b
expression would reduce the VitD uptake through its receptor.
Chitin, Characteristic, Sources, and Biomedical Application
Authors: Shahbaz Umar 
Published: June 2020

Background:
Chitin stands at second, after cellulose, as the most abundant polysaccharide
in the world. Chitin is found naturally in marine environments as it is a crucial structural component of
various marine organisms.

Methods:
Different amounts of waste chitin and chitosan can be discovered in the environment. Chitinase
producing microbes help to hydrolyze chitin waste to play an essential function for the removal of chitin
pollution in the Marine Atmosphere. Chitin can be converted by using chemical and biological methods
into prominent derivate chitosan. Numerous bacteria naturally have chitin degrading ability.

Results:
Chitin shows promise in terms of biocompatibility, low toxicity, complete biodegradability,
nontoxicity, and film-forming capability. The application of these polymers in the different sectors of
biomedical, food, agriculture, cosmetics, pharmaceuticals could be lucrative. Moreover, the most recent
achievement in nanotechnology is based on chitin and chitosan-based materials.

Conclusion:
In this review, we examine chitin in terms of its natural sources and different extraction
methods, chitinase producing microbes and chitin, chitosan together with its derivatives for use in biomedical
and agricultural applications.
Drug Delivery Assessment of a Novel Triple Antibiotic-Eluting Injectable Platelet-Rich Fibrin Scaffold: An In Vitro Study
Authors: Rafiee Azade , Memarpour Mahtab , Taghvamanesh Sara , Karami Forough , Karami Somayeh , Morowvat Mohammad H. 
Published: June 2020

Background:
Intracanal disinfection is a critical, yet challenging goal for long-term success
in regenerative-based treatments. This in-vitro study aimed to assess the release profile of triple antibiotic-
eluting Injectable Platelet-Rich Fibrin (I-PRF) constructs in 28 days.

Methods:
I-PRF scaffolds containing triple antibiotic mixture [Metronidazole (MET), Ciprofloxacin
(CIP), and Minocycline (MINO)] by immersion (group one), I-PRF scaffolds containing triple antibiotic
mixture by integration (group two), and antibiotic-free I-PRF scaffolds (group three) were fabricated.
The antibiotic release from the scaffolds was measured using High-Performance Liquid Chromatography
(HPLC) (the mobile phase of 0.1% formic acid and methanol (35:65 v/v), a C18 analytical
column (150 × 4.6 mm, 5 μm) at a flow rate of 0.7 mL/min, at 25ºC) at days 1, 3, 7, 14, 21, and 28.

Results:
Retention times for MINO, CIP, and MET were achieved as 2.3, 2.6, and 3.1 min, respectively.
The maximum UV absorbance values for CIP, MET, and MINO were 268 nm, 278 nm, and 350
nm, respectively. The results of the first group showed burst release within the first 24 hours followed
by sustained maintenance of all three antibiotics up to 14 days. MINO and MET were still detectable in
the third week. The second group could not sustainably release the antibiotics.

Conclusions:
The developed method for the simultaneous identification and quantification of each antibiotic
in I-PRF was sensitive and quick. Overall, group one could take up the antibiotics in adequate
quantities and then subsequently release them over the study period.
Unveiling the Biodiversity of Hyperthermophilic Archaea in Jharia Coal Mines: Potential Threat to Methanogenesis?
Authors: Jha Priyanka , Singh Joginder , Vidyarthi Ambarish S. , Prasad Ram 
Published: June 2020

Aim:
To examine the biodiversity of archaeal sulfate reducers and methanogens present in
the underground coal mines of Jharia using metagenomics and pyrosequencing.

Objectives:
1) Bioinformatical analysis of the metagenomic data related to a taxonomic analysis obtained
from the coal to investigate complete archaeal taxonomic features of the coal bed methane
(CBM) microbiome. 2) Bioinformatical analysis of the metagenomic data related to a functional analysis
obtained from the coal to investigate functional features relating to taxonomic diversity of the
CBM microbiome. 3) The functional attributes have been examined specifically for ORFs related to
sulfite reduction and methanogenesis.

:
The taxonomic and functional biodiversity related to euryarchaeota will help in a better understanding
of the obstacles associated with methane production imposed by the sulfate reducers.

Background:
The microbial methanogenesis in the coal microbiome is a resultant of substrate utilization
by primarily fermentative bacteria and methanogens. The present work reveals the biodiversity of
archaeal sulfate reducers and methanogens present in the underground coal mines of Jharia using metagenomics
and pyrosequencing.

Methodology:
Bioinformatical analysis for structural and functional attributes was accomplished using
MG-RAST. The structural analysis was accomplished using RefSeq database, whereas the functional
analysis was done via CoG database with a cut off value, a sequence percent identity, and sequence
alignment length cut off of 1e−5, 60% and 45, respectively.

Results:
Attained communities revealed the dominance of hyperthermophilic archaea Pyrococcus furiosus
along with Thermococcus kodakarensis in the coal metagenome.The obtained results also suggest
the presence of dissimilatory sulfite reductase and formylmethanofuran dehydrogenase, formylmethanofuran:
tetrahydromethanopterin formyltransferase involved in sulfite reduction and methanogenesis,
respectively, in the microbiome.

Conclusion:
This report is the first attempt to showcase the existence of specific euryarchaeal diversity
and their related functional attributes from Jharia coal mines through high throughput sequencing.
The study helps in developing a better understanding of the presence of indigenous microbes (archaea)
and their functions in the coal microbiome, which can be utilized further to resolve the energy crisis.
Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders
Authors: Giménez Virna Margarita Martín , Sanz Raúl Lelio , Marón Feres José Mocayar , Ferder León , Manucha Walter 
Published: June 2020

Background:
The neuroinflammatory process is associated with the pathogenesis of many
cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D
seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack
of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the
essential mechanisms of blood pressure regulation.

Purpose of Review:
This review summarizes the latest studies carried out to evaluate the primary
mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central
nervous system. Besides, the present article condenses the evidence supporting the link between vitamin
D and the RAAS in hypertension and neuroinflammation.

Highlights Standpoints:
Vitamin D deficiency is highly prevalent in the world, and the rising prevalence
of neuroinflammatory diseases and associated pathologies such as hypertension around the world
justifies the urgent need of searching new and more effective therapeutic methods that could be related
to RAAS modulation and vitamin D levels management.
Epidemiology of HIV in Iran
Authors: Najafi Zeinab , Taj Leila , Dadras Omid , Ghadimi Fatemeh , Moradmand Banafsheh , SeyedAlinaghi SeyedAhmad 
Published: June 2020

:
Iran has been one of the active countries fighting against HIV/AIDS in the Middle East
during the last decades. Moreover, there is a strong push to strengthen the national health management
system concerning HIV prevention and control. In Iran, HIV disease has its unique features,
from changes in modes of transmission to improvement in treatment and care programs, which can
make it a good case for closer scrutiny. The present review describes the HIV epidemic in Iran from
the first case diagnosed until prevention among different groups at risk and co-infections. Not only
we addressed the key populations and community-based attempts to overcome HIV-related issues in
clinics, but we also elaborated on the efforts and trends in society and the actual behaviors related to
HIV/AIDS. Being located in the Middle East and North Africa (MENA) region, given the countryspecific
characteristics, and despite all the national efforts along with other countries in this region,
Iran still needs to take extra measures to reduce HIV transmission, especially in health education.
Although Iran is one of the pioneers in implementing applicable and appropriate policies in the
MENA region, including harm reduction services to reduce HIV incidence, people with substance
use disorder continue to be the majority of those living with HIV in the country. Similar to other
countries in this region, the HIV prevention and control programs aim at 90-90-90 targets to eliminate
HIV infection and reduce the transmission, especially the mother-to-child transmission and
among other key populations.
The Potential Prebiotic Effects of Yacon (Smallanthus sonchifolius) in Colorectal Cancer
Authors: Verediano Thaísa A. , Viana Mirelle L. , das G.V. Tostes Maria , Costa Neuza M.B. 
Published: June 2020

Background:Colorectal cancer is caused by genetic predisposition and lifestyle risk factors and is associated with altered homeostasis of the intestinal microbiota. Evidence suggests that chronic infection and inflammation contribute to carcinogenic mutagenesis and promote cancer initiation and progression. Food components with prebiotic properties, such as fructooligosaccharides (FOS), promote intestinal integrity and health benefits. Yacon (Smallanthus sonchifolius) is an abundant source of FOS, which are fermented by beneficial bacteria, improving the intestinal environment affected by colorectal cancer.Objective:In the current review, the aim was to discuss colorectal cancer and its inflammatory process of development. Also, some general aspects concerning yacon roots and its prebiotic properties are described. Finely, the beneficial effects of yacon to reduce intestinal parameters altered due to colorectal cancer are summarized.Conclusion:It was verified that yacon might improve immunological parameters, intestinal barrier, intestinal microbiota, and inflammation in induced colorectal cancer in animals, especially. Researches with humans must be further investigated to prove these positive effects.
Evaluation of Anti-Diabetic Potential of Corn Silk in High-Fat Diet/ Streptozotocin-Induced Type 2 Diabetes Mice Model
Authors: Sheng Li , Chen Qian , Di Lei , Li Ning 
Published: June 2020

Background:
Corn silk is the elongated stigma of the female flower of Zea mays and traditionally
used to treat diabetes mellitus (DM).

Objective:
To investigate the beneficial effects of corn silk extract (CSE) on HFD/STZ-induced diabetic
C56BL/6J mice.

Methods:
Establishment of a T2DM model through feeding HFD combined with STZ. T2DM was
randomly divided into 5 groups: diabetic control mice treated with vehicle (model group, n=10), metformin-
treated group (metformin: 150 mg/kg.d, n=10), three CS-treated groups (CS: 300, 600 and
1200 mg/kg.d, n=10). After four weeks of CS treatment, the body weight, FBG, IR, TC, TG, LDL-C,
MDA and SOD levels of mice were measured. In addition, the liver tissue was histomorphologically
analyzed by HE stain followed a light microscopy observation.

Results:
4-week CSE treatment significantly reduced FBG and enhanced the glucose tolerance; improved
IR indicated by decreased HOMA-IR and elevated ISI; alleviated hyperlipidemia indicated by
decreased TC, TG, LDL-C, and increased HDL-C; reduced oxidative stress by decreased MDA and
elevated SOD activity; decreased hepatic lipid accumulation and prevented liver tissue morphological
change in T2DM. In addition, CSE treatments effectively prevent the weight gain loss of diabetic mice.

Conclusion:
These results confirmed the traditionally claimed benefits of corn silk on DM, which
suggested that the corn silk possessed the anti-diabetic potential and could be further developed as a
cheap and plant-derived agent for the treatment of type 2 diabetes mellitus.
Taxonomy of Cluster-Based Target Tracking System in Wireless Sensor Networks
Authors: Odeh Ammar 
Published: June 2020

Background:
In the last decade, with the advancement of big data technology and the
internet of things, Wireless Sensor Networks (WSN) have become fundamental for the success of
a different range of applications especially those demanding massive data processing.

Objective:
This paper investigates several tracking methods to introduce a novel cluster-based target
tracking analysis model.

Methods:
Some crucial factors of the cluster-based routing protocols are demonstrated, and a
comparison among these different methods is conducted according to our taxonomy, such as cluster
formation, predicate/proactive, target speed, single or multi-object tracking, boundary problem,
scalability, energy efficiency, and communication cost. This can help the community of researchers
by providing clear information for further study.

Results and Conclusion:
The proposed paper compares the differences and similarities between
the available approaches across different categories in terms of the cluster construction, clustering
method, object speed, number of objects, boundary problem, and scalability. Finally, we can recognize
some open issues that have so far gained little attention or are unexplored yet.
Biosynthesis of Silver Nanoparticles from Synechocystis sp to be Used as a Flocculant Agent with Different Microalgae Strains
Authors: Fathy Wael , Elsayed Khaled , Essawy Ehab , Tawfik Eman , Zaki Ayman , Abdelhameed Mohamed S. , Hammouda Ola 
Published: June 2020

Background:
Biofuels produced from trans-esterification of high lipid
content in microalgae represent a promising alternative renewable source of energy
to the limited and depleted global fossil fuel reservoir. The most critical step in
such a process is the harvesting of algal cells.

Objective:
We aimed to improve the current methodology for microalgae harvesting
via utilizing biosynthesized silver nanoparticles (AgNPs) from Synechocystis sp.
ElfSCS31 as an eco-friendly, stable, and affordable flocculant agent.

Methods:
AgNPs were prepared by the green synthesis method using the alcoholic
extract of Synechocystis sp. ElfSCS31. The synthesized nanoparticles were
characterized by Zeta sizer, X-ray Diffraction (XRD), Fourier Transform Infrared
Spectroscopy (FT-IR), and UV-Vis Spectroscopy. Biosynthesised AgNPs were
applied for harvesting 20 microalgae strains, and then, harvesting efficiency was
determined by UV Spectrophotometry.

Results:
Our results revealed an average size of polydispersed nanoparticles
ranging from 10 to 100 nm for prepared AgNPs and the potential of 1.78 mV, with
an average crystallite size of 22 nm. Biosynthesised AgNPs exhibited harvesting
efficiency towards different strains of microalgae, which reached 97% in some
strains as in Chlorella lobophora and Chlorococcum oleofaciens.

Conclusion:
The presented study introduces a feasible strategy using biosynthesized
AgNPs as a flocculant agent to harvest different strains of microalgae at normal
growth conditions of light and temperature. Our developed method could replace the
classical high-cost step of harvesting that leads to unravelling the full potential of
microalgae as a promising and fascinating source for biofuels production.
Promoção do desenvolvimento local sustentável: estudo comparativo das iniciativas do Brasil e da União Europeia.
Authors: Bier Clerilei Aparecida , Simões Rogério , Dabrowski Isabella , Carubelli Carlos Alberto Zapata 
Published: June 2020

A partir das noções de desenvolvimento local e desenvolvimento sustentável, buscou-se analisar neste artigo, utilizando-se do método de Estudo Comparado, duas iniciativas de desenvolvimento local sustentável que tem como ponto central a participação cidadã e o envolvimento da comunidade, e atuação conjunta com a administração pública por meio da coordenação eficiente de governos locais para o desenvolvimento dos objetivos traçados. Revelou-se no estudo da iniciativas DLBC – Desenvolvimento local de base comunitária aplicada no Brasil pelo Governo Federal em comunidades brasileiras pelo projeto de cooperação técnica INCRA/IICA, e iniciativa denominada LEADER – Liaison Entre Actions pour le Développement de l’Economie Rurale desenvolvida pela União Europeia, que uma estrutura de governança pautada na mobilização das energias da sociedade, nas suas capacidades e potencialidades bem como na atuação do Estado é pedra angular das mudanças sociais e econômicas pretendidas no processos de desenvolvimento local sustentável e fortalecimento das instituições locais com a conscientização dos envolvidos
Correlation of Increased Triglyceride with Alteration in Haematological and Biochemical Parameters in Apparently Healthy Individuals
Authors: Tayeb Bizhar Ahmed , Abdurrahman Shafan Mohammed , Tamar Rahma Yassin 
Published: June 2020

Objective: The current study was aimed to evaluate and assess the correlation between adulterations of haematological parameters with high level of triglyceride in healthy smoker individuals.
Methods: Ninety volunteers were participated in this study, smokers (n=70) and non-smokers (n=20). Complete blood count and other tests were performed by using fully automated haematological analyser devices.
Results: The values of white blood cells (p=0.005), red blood cells (p= 0.01), haemoglobin content (p=0.03), haematocrit (p= 0.042), mean corpuscular haemoglobin and mean corpuscular volume (p= 0.003 and p= 0.0022 respectively) in smokers showed greater when compared to no-smokers. The values of total cholesterol and triglyceride appeared significantly greater in smokers than in control subjects. All other calculated measure parameters did not show significantly different between the two groups.
Conclusions: The current study showed that continues cigarette smoking among healthy individuals has adverse effects on both biochemical and haematological parameters but not in kidney function activities. There is a strong correlation between high levels of triglyceride with increased levels of blood parameters in smoker group.
Work Environment in Mosul city Hospitals
Authors: Al-Fathy Marab Younis Abdullah , Ali Nahla Khalaf , Ahmed Muna Muneer 
Published: June 2020

Objectives: Investigating the vision of health care workers about their work environment.
Methods: A cross sectional study design was done in eight hospital in Mosul city for a period extended for ten months duration 1st Jan-Nov 2018 including 673 health care worker choosing by simple random selection, using standardize questionnaire form consist from three item psycho-social, physical condition of work place and practicing of personal protective equipment. Data were presented in suitable tables and figures. Percentage were calculated for the various group variables using Chi-Square for Goodness of FitØŒ Mean Â± SD, P-value at a level of significance equal to or less than 0.05 was considered.
Results: The mean ageÂ± SD of study sample was 38.28Â±9.71 as 57.1% , 42.9% male and female respectively. The study revealed overall percentage of agreement regarding psychological and social, physical condition of work environment was 29.1% and 41.6% respectively. Compliance with practicing personal protection equipment was low (29.4%). The grand mean assessment of all over work place condition it was 1.8 below the cut-off point (cut â€“ off point = 2).
Conclusions: The study concluded that work environment (psychological, social and physical) condition and compliance to practicing standard precaution were unacceptable to the health worker in Mosul city hospital 2018.