bluuebunny/crossref_metadata_2025_split huggingface dataset:
Majorization of the Temljakov Operators for the Bavrin Families in $${\mathbb {C}}^n$$
Authors: Długosz Renata , Liczberski Piotr , Trybucka Edyta 
Published: March 2020

AbstractThe paper concerns holomorphic functions in complete bounded n-circular domains $${{\mathcal {G}}}$$G of the space $${\mathbb {C}}^n$$Cn. The object of the present investigation is to solve majorization problem of Temljakov operator. This type of problem has been studied earlier in Liczberski and Żywień (Folia Sci Univ Tech Res 33:37–42, 1986), Liczberski (Bull Technol Sci Univ Łódź 20:29–37, 1988) and Leś-Bomba and Liczberski (Demonstratio Math 42(3):491–503, 2009). In this paper we considered the family $${{\mathcal {M}}}_{{{\mathcal {G}}}}\cap {{\mathcal {F}}}_{0,k}({{\mathcal {G}}})$$MG∩F0,k(G), i.e. the functions of the Bavrin family $${{\mathcal {M}}}_{{{\mathcal {G}}}}$$MG, which are (0, k)-symmetrical.
What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins
Authors: Suryawanshi Ashwini , Schaefer Karolin , Holz Oliver , Apel David , Lange Ellen , Hayward David C. , Miller David J. , Hassel Monika 
Published: March 2020

AbstractAcross the Bilateria, FGF/FGFR signaling is critical for normal development, and in bothDrosophilaand vertebrates, docking proteins are required to connect activated FGFRs with downstream pathways. While vertebrates use Frs2 to dock FGFR to the RAS/MAPK or PI3K pathways, the unrelated protein, downstream of FGFR (Dof/stumps/heartbroken), fulfills the corresponding function inDrosophila. To better understand the evolution of the signaling pathway downstream of FGFR, the available sequence databases were screened to identify Frs2, Dof, and other key pathway components in phyla that diverged early in animal evolution. While Frs2 homologues were detected only in members of the Bilateria, canonical Dof sequences (containing Dof, ankyrin, and SH2/SH3 domains) were present in cnidarians as well as bilaterians (but not in other animals or holozoans), correlating with the appearance of FGFR. Although these data suggested that Dof coupling might be ancestral, gene expression analysis in the cnidarianHydrarevealed thatDofis not upregulated in the zone of strongFGFRaandFGFRbexpression at the bud base, where FGFR signaling controls detachment. In contrast, transcripts encoding other, known elements of FGFR signaling in Bilateria, namely the FGFR adaptors Grb2 and Crkl, which are acting downstream of Dof (and Frs2), as well as the guanyl nucleotide exchange factor Sos, and the tyrosine phosphatase Csw/Shp2, were strongly upregulated at the bud base. Our expression analysis, thus, identified transcriptional upregulation of known elements of FGFR signaling at theHydrabud base indicating a highly conserved toolkit. Lack of transcriptionalDofupregulation raises the interesting question, whetherHydraFGFR signaling requires either of the docking proteins known from Bilateria.
Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants
Authors: Wöll Anna K. , Hubbuch Jürgen 
Published: March 2020

Abstract
Formulation conditions have a significant influence on the degree of freeze/thaw (FT) stress-induced protein instabilities. Adding cryoprotectants might stabilize the induced FT stress instabilities. However, a simple preservation of protein stability might be insufficient and further methods are necessary. This study aims to evaluate the addition of a heat cycle following FT application as a function of different cryoprotectants with lysozyme as exemplary protein. Sucrose and glycerol were shown to be the most effective cryoprotectants when compared to PEG200 and Tween20. In terms of heat-induced reversibility of aggregates, glycerol showed the best performance followed by sucrose, NaCl and Tween20 systems. The analysis was performed using a novel approach to visualize complex interplays by a clustering and data reduction scheme. In addition, solubility and structural integrity were measured and confirmed the obtained results.

Graphic abstract
A critical examination of the main premises of Traditional Chinese Medicine
Authors: Eigenschink Michael , Dearing Lukas , Dablander Tom E. , Maier Julian , Sitte Harald H. 
Published: March 2020

SummaryTraditional Chinese Medicine (TCM) consists of a plethora of therapeutic approaches aiming to both characterize and treat diseases. Its utilization has gained significant popularity in the western world and is even backed by the World Health Organization’s decision to include TCM diagnostic patterns into the new revision of the International Classification of Diseases code, the global standard for diagnostic health information. As these developments and potentially far-reaching decisions can affect modern healthcare systems and daily clinical work as well as wildlife conservation, its underlying factual basis must be critically examined. This article therefore provides an overview of the evidence underlying the basic TCM concepts, such as Qi, meridians, acupuncture, pulse and tongue diagnostics as well as traditional herbal treatments. Moreover, it discusses whether scientific literature on TCM reflects the current standard for evidence-based research, as described in good scientific practice and good clinical practice guidelines. Importantly, misinformation regarding the therapeutic efficacy of animal-derived substances has lead and currently leads to problems with wildlife preservation and animal ethics. Nevertheless, the (re-)discovery of artemisinin more than 50 years ago introduced a novel development in TCM: the commingling of Eastern and Western medicine, the appreciation of both systems. The need for more rigorous approaches, fulfilment of and agreement to current guidelines to achieve high-quality research are of utmost relevance. Thereby, ancient knowledge of herbal species and concoctions may serve as a possible treasure box rather than Pandora’s box.
Crowdsourcing sensitive data using public displays—opportunities, challenges, and considerations
Authors: Alorwu Andy , van Berkel Niels , Goncalves Jorge , Oppenlaender Jonas , López Miguel Bordallo , Seetharaman Mahalakshmy , Hosio Simo 
Published: March 2020

AbstractInteractive public displays are versatile two-way interfaces between the digital world and passersby. They can convey information and harvest purposeful data from their users. Surprisingly little work has exploited public displays for collecting tagged data that might be useful beyond a single application. In this work, we set to fill this gap and present two studies: (1) a field study where we investigated collecting biometrically tagged video-selfies using public kiosk-sized screens, and (2) an online narrative transportation study that further elicited rich qualitative insights on key emerging aspects from the first study. In the first study, a 61-day deployment resulted in 199 video-selfies with consent to leverage the videos in any non-profit research. The field study indicates that people are willing to donate even highly sensitive data about themselves in public. The subsequent online narrative transportation study provides a deeper understanding of a variety of issues arising from the first study that can be leveraged in the future design of such systems. The two studies combined in this article pave the way forward towards a vision where volunteers can, should they so choose, ethically and serendipitously help unleash advances in data-driven areas such as computer vision and machine learning in health care.
Children’s Capacities and Paternalism
Authors: Godwin Samantha 
Published: March 2020

AbstractPaternalism is widely viewed as presumptively justifiable for children but morally problematic for adults. The standard explanation for this distinction is that children lack capacities relevant to the justifiability of paternalism. I argue that this explanation is more difficult to defend than typically assumed. If paternalism is often justified when needed to keep children safe from the negative consequences of their poor choices, then when adults make choices leading to the same negative consequences, what makes paternalism less justified? It seems true that ordinary adults have capacities enabling them to promote their interests in ways most children lack. This can explain why paternalism is more often justified towards children than adults. What is not explained, however, is why paternalism would be justifiable for children, but not adults, when neither possess the relevant interest-promoting capacities—exactly the cases when paternalism towards adults might be considered. I argue that this dilemma undercuts capacities-based explanations for the belief that childhood is distinctively relevant for the permissibility of paternalism. I then address defenses of both consequentialist and deontological versions of the capacities-based explanation. Absent this capacities-based explanation, I argue that the intuition that less demanding justificatory standards apply to paternalism when directed at children than when directed towards adults presents unresolved problems for egalitarians.
Global vs Sectoral Factors and the Impact of the Financialization in Commodity Price Changes
Authors: Poncela Pilar , Senra Eva , Sierra Lya Paola 
Published: March 2020

AbstractCommodity prices influence price levels of a broad range of goods and, in the case of some developing economies, production and export activity. Therefore, information about future commodity inflation is useful for central banks, forward-looking policy-makers, and economic agents whose decisions depend on their expectations about it. After 2004, we have witnessed the so-called financialization of the commodity markets, which might induce greater communalities among commodity prices. This paper reports evidence on the relevance of the forecasting content of co-movement after 2004. With the use of large and small scale factor models we find that for the short run, in addition to dynamics, sectoral communality has relevant predictive content. For 12 months ahead, dynamics lose relevance while communality remains relevant.
Simulated microgravity significantly altered metabolism in epidermal stem cells
Authors: Li Bin-Bin , Chen Zheng-Yang , Jiang Nan , Guo Song , Yang Jia-Qi , Chai Shao-Bin , Yan Hong-Feng , Sun Pei-Ming , Hu Gang , Zhang Tao , Xu Bing-Xin , Sun Hong-Wei , Zhou Jin-Lian , Yang He-Ming , Cui Yan 
Published: March 2020

AbstractSimulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia and loss of electrolyte and fluids. Epidermal stem cells (EpSCs) were cultured in a rotary cell culture system (RCCS) bioreactor to simulate microgravity. The metabolites of EpSCs were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with normal gravity (NG) group, a total of 57 different metabolites of EpSCs were identified (P < 0.05, VIP > 1), including lipids and lipid-like molecules (51 molecules), amino acids (5 molecules), nucleosides, nucleotides, and analogues (1 molecule). According to the partial least squares discriminant analysis (PLS-DA) score plot, a VIP > 1 and P < 0.05 were obtained for the 57 different metabolites, of which 23 molecules were significantly downregulated and 34 were significantly upregulated in simulated microgravity (SMG) group. These results showed that SMG has a significant impact on different pathways, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that multiple pathways were involved, mainly the amino acid metabolism pathway, lipid metabolism pathway, membrane transport pathway, and cell growth and death pathways. Thus, the metabolic profile of EpSCs was changed under SMG. Exploring the metabolic profile of EpSCs would be helpful to further understand the growth characteristics of EpSCs under SMG, which will provide a new approach to explore the metabolomics mechanism of stress injury and repair trauma under SMG.
Does quality of care in hip fracture vary by day of admission?
Authors: Farrow Luke , Hall Andrew , Aucott Lorna , Holt Graeme , Myint Phyo K. 
Published: March 2020

Abstract
Summary
This study investigates if the day of the week a person is admitted with a hip fracture influences the quality of care they receive. We found those admitted Thursday and Friday were likely to obtain poorer postoperative care, indicating a need to optimize services ensuring equality for all.

Purpose
We sought to investigate how the day of admission affects the quality of care provided to hip fracture patients according to national standards (The Scottish Standards of Care for Hip Fracture Patients [SSCHFP]).

Methods
Retrospective analysis of national cohort data. Data were collected by the Scottish Hip Fracture Audit (SHFA) local audit co-ordinators (LACs) at participating Scottish hospitals on behalf of NHS Scotland and the Scottish Government. Adherence to the SSCHFP included assessment of both individual and cumulative standard attainment as a marker for quality of patient care.

Results
From January 2014 to April 2018, 15,351 admissions for hip fracture were recorded. Compared with Monday admission (reference day), patients admitted on a Thursday or Friday had a significantly lower likelihood of achieving the postoperative standards of prompt mobilization (OR 1.77; p < 0.001 & OR 1.48; p < 0.001, respectively); prompt physiotherapy assessment (OR 8.61; p < 0.001 & OR 3.47; p < 0.001, respectively); and prompt comprehensive geriatric assessment (OR 1.88; p < 0.001 & OR 1.41; p < 0.001, respectively). Patients admitted on a Friday or Saturday were less likely to receive the preoperative standards of no delay prior to theatre (OR 1.24; p = 0.001 & OR 1.23; p = 0.002, respectively) and avoidance of repeat fasting (OR 1.22; p = 0.009 & OR 1.22; p = 0.01, respectively).

Conclusion
Patients admitted on Thursday or Friday were significantly more likely to not receive postoperative care standards than patients admitted on the reference day (Monday). This appears to be related to inequalities in service provision for Saturday and Sunday compared with the rest of the week.
Delirium Screening in Neurocritical Care and Stroke Unit Patients: A Pilot Study on the Influence of Neurological Deficits on CAM-ICU and ICDSC Outcome
Authors: von Hofen-Hohloch Judith , Awissus Carolin , Fischer Marie Michèle , Michalski Dominik , Rumpf Jost-Julian , Classen Joseph 
Published: March 2020

Abstract
Background/Objective
Delirium is a common complication in critically ill patients with a negative impact on hospital length of stay, morbidity, and mortality. Little is known on how neurological deficits affect the outcome of commonly used delirium screening tools such as the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the Intensive Care Delirium Screening Checklist (ICDSC) in neurocritical care patients.

Methods
Over a period of 1 month, all patients admitted to a neurocritical care and stroke unit at a single academic center were prospectively screened for delirium using both CAM-ICU and ICDSC. Tool-based delirium screening was compared with delirium evaluation by the treating clinical team. Additionally, ICD-10 delirium criteria were assessed.

Results
One hundred twenty-three patients with a total of 644 daily screenings were included. Twenty-three patients (18.7%) were diagnosed with delirium according to the clinical evaluation. Delirium incidence amounted to 23.6% (CAM-ICU) and 26.8% (ICDSC). Sensitivity and specificity of both screening tools were 66.9% and 93.3% for CAM-ICU and 69.9% and 93.9% for ICDSC, respectively. Patients identified with delirium by either CAM-ICU or ICDSC presented a higher proportion of neurological deficits such as impaired consciousness, expressive aphasia, impaired language comprehension, and hemineglect. Subsequently, generalized estimating equations identified a significant association between impaired consciousness (as indexed by Richmond Agitation and Sedation Scale) and a positive delirium assessment with both CAM-ICU and ICDSC, while impaired language comprehension and hemineglect were only associated with a positive CAM-ICU result.

Conclusions
A positive delirium screening with both CAM-ICU and ICDSC in neurocritical care and stroke unit patients was found to be significantly associated with the presence of neurological deficits. These findings underline the need for a more specific delirium screening tool in neurocritical care patients.
Clinical management of ageing people living with HIV in Europe: the view of the care providers
Authors: Boffito Marta , Ryom Lene , Spinner Christoph , Martinez Esteban , Behrens Georg , Rockstroh Jürgen , Hohenauer Johannes , Lacombe Karine , Psichogyiou Mina , Voith Norbert , Mallon Patrick , Branco Teresa , Svedhem Veronica , dÁrminio Monforte Antonella 
Published: March 2020

Abstract
Background
Although guidelines for the management of HIV infection include recommendations for aging people living with HIV (PLWH), clinical practice of European HIV care providers may vary.

Method
We performed a study using a 3-phase Delphi methodology by involving a panel of clinicians with expertise in HIV infection clinical management. The main aim of the study was to assess the care provider prospective on how HIV clinical care should be delivered to ageing PLWH. The first phase involved ten clinicians to identify HIV comorbidities of interest. The second and third phases recruited clinicians virtually via a web-based questionnaire that included 137 questions focussed on 11 comorbidities (e.g. cardiovascular disease, pulmonary disease, etc.).

Results
Results were analysed thematically and consensus (or not) among European physicians reported. Ninety-seven and 85 responses were collected in phase 2 and 3, respectively. High levels of agreement were found among clinical care providers across Europe and with the European AIDS Conference Society guidelines regarding key items of clinical management of comorbidities in ageing PLWH.

Conclusion
However, we identified some important gaps, such as the lack of standardisation or implementation of the assessment of frailty or menopause, which are emerging as important factors to optimise ageing PLWH clinical care. Further studies are warranted to confirm whether intensified screening translates into HIV morbidity advances.
The Effect of Different Surgical Methods on Female and Male Sexual Activity and Marital Quality in Patients With Early-Stage Cervical Cancer
Authors: Zhang Yunqiang , Sun Shugen , Ding Jingxin , Hua Keqin 
Published: March 2020

Abstract

Introduction
Sexual activity is important for marital quality, especially in cervical cancer survivors. Vagina extension following laparoscopic radical hysterectomy with bilateral ovarian preservation (VEOP), vagina extension following laparoscopic radical hysterectomy with bilateral oophorectomy (VEBO), radical hysterectomy with bilateral ovarian preservation (RHOP), and radical hysterectomy with bilateral oophorectomy (RHBO) are the common surgeries for young cervical cancer patients.

Aim
To investigate the effect of the 4 surgical methods on female/male sexual activity and marital quality in early-stage cervical cancer survivors.

Methods
Multiple linear regression analysis was conducted in 205 patients with stage Ia1–IIa2 cervical cancer to evaluate the factors that affected male/female sexual function and marital quality.

Main Outcome Measure
Female Sexual Function Index (FSFI), modified Kupperman Index (KI), modified Sexual Life Quality Questionnaire (mSLQQ-QoL), and ENRICH marital inventory were used to reflect changes in female/male sexual function and marital quality in the 4 groups.

Results
Female/male sexual function and marital quality were both highest in the VEOP group and lowest in the RHBO group. The regression results showed that ovarian preservation and vaginal extension were associated with female/male sexual function and marital quality. Furthermore, when vaginal extension and ovarian preservation were replaced by vaginal length, sexual psychological change, and hormone level index (KI), respectively; male sexual function was associated with vaginal length and sexual psychological change, whereas female sexual function and marital quality were only associated with hormone level and sexual psychological change. Clinical statistics found that four-fifths of the recurrent patients had vaginal extension (P = .042), and 3-quarters of these patients had large tumors.

Conclusion
Ovarian preservation and vaginal extension are both important for male/female sexual activity and marital quality. Vaginal extension may play a positive role in female sexual life via psychology and in male sexual life via vaginal length. Vaginal extension may not be suitable for patients with large masses.
Investigation of the Social Determinants of Sexual Satisfaction in Iranian Women
Authors: Afzali Mansoureh , Khani Soghra , Hamzehgardeshi Zeinab , Mohammadpour Reza-Ali , Elyasi Forouzan 
Published: March 2020

Abstract

Introduction
A person’s sexual satisfaction reflects their judgment and analysis of their own sexual behavior. Factors that affect sexual satisfaction vary in different societies and cultures.

Aim
This study investigated the determinants of sexual satisfaction in women referred to health centers in Sari, north of Iran, in 2016.

Methods
This cross-sectional study investigated 490 women who had been referred to health centers in 2016 and who were qualified for the study; the population was selected using convenient sampling method.

Main Outcome Measure
The main outcome of this study was sexual satisfaction that assessed by the Larson’s sexual satisfaction questionnaire. Other Data were 2 questionnaires: the general health questionnaire–28 and a researcher-made questionnaire developed on factors related to sexual satisfaction. Data were analyzed with IBM SPSS software using the one-way analysis of variance, Pearson correlation coefficient, and t-test. To determine the predictors of sexual satisfaction, all the significant independent variables were incorporated into a linear regression model.

Results
The average age of the women in this study was 33.6 years, and average sexual satisfaction score was 99.26. The results of the linear regression model showed that the spouse’s job as a laborer (P = .003), a low income (P &lt; .002), insufficient income of the spouse (P &lt; .001), and dissatisfaction with being a woman (P &lt; .001) were the main social determinants of sexual satisfaction (r2 = 0.54).

Conclusion
It can be concluded from the findings of this study that several factors influence women’s sexual satisfaction. The main social determinants of women’s sexual satisfaction were dissatisfaction with their gender, the spouse’s job as a laborer, low income, and insufficient income. Sexual healthcare providers can play a prominent role in increasing women’s sexual satisfaction, thereby, improving the quality of their sexual life by identifying and discussing ways to control them.
The ‘brutal fecundity of violence’: Feminist methodologies of International Relations
Authors: Kinsella Helen M. , Shepherd Laura J. 
Published: March 2020

AbstractThis article highlights Marysia Zalewski's scholarship as reflective and generative of the multifarious sources and contributions of feminist IR and its ‘scavenger methodologies’, which seek to centre subjects, processes, and practices historically excluded, ignored, and minimised. The productive depth of her scholarship is evident in the uniqueness of each article in this collection, all of which distinctly document the uses to which Zalewski's writings can be uniquely put. Each of the articles performs a ‘turning operation’ of sorts on the elementals of feminist IR (gender/women/power/difference) and brings further elaborations of masculinities, sexualities, silences as well as screams, that shift and change what is taken to be feminist research/method – at each point disordering our sensibilities and our assumptions as to what we do when we do feminist work.