bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complicações locais e sistêmicas em pacientes pós-angioplastia coronariana transluminal percutânea primária / Local and systemic complications in patients after primary percutaneous transluminal coronary angioplasty
Authors: Jardim Cardoso Karoline , Monteiro da Silva Debora 
Published: December 2024

Objetivo: descrever as principais complicações pós-angioplastia primária em um hospital universitário. Método: pesquisa descritiva, com análise documental de registros de 78 pacientes submetidos à angioplastia primária. A coleta de dados ocorreu de setembro a novembro de 2020, em prontuários impressos, através de instrumento previamente elaborado. A análise foi por estatística descritiva. Resultados: predomínio de idosos, com média de 60,7 anos, do sexo masculino (76%), hipertensos (67,9%) e tabagistas (35,9%). As principais complicações encontradas foram hematoma (17,9%), nefropatia induzida por contraste (12,8%) e retenção urinária (5,1%). Os eventos cardíacos adversos maiores mais prevalentes foram reestenose coronariana (7,7%), óbito cardíaco (3,8%), infarto agudo do miocárdio (1,3%) e cirurgia de revascularização do miocárdio de urgência (1,3%). Conclusões: a identificação das complicações pós-angioplastia primária pode ofertar subsídios para qualificar o cuidado através da criação de protocolos de prevenção e intervenção precoce aos eventos adversos aos pacientes submetidos ao procedimento. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessado pelo seguinte endereço eletrônico: Complicações locais e sistêmicas em pacientes pós-angioplastia coronariana transluminal percutânea primária | Journal of Nursing and Health (ufpel.edu.br)
Imagining Siberia: Cartographic Motive in the Novel of A. Ivanov Tobol
Authors: Snežko Julia 
Published: December 2024

The The article considers the role of cartographic motif in the conceptualisation of space in Russian writer Alexei Ivanov’s novel Tobol. The paper reveals the connection of this motif with the main plot lines of the novel, with the structure of the novelistic space, as well as with its ideological component. The study concludes that the map functions both as a tool for traversing space (and thus conquering it), as a means of awakening poetic imagination, and as a crucial element in attempts to imagine Siberia.Drawing on the ideas of American geographer Yi-Fu Tuan, the article shows that the map in the novel is one of the most important elements in the attempt to transform space into place.
A next year after the tenth anniversary
Authors: Medvedev Dmitry 
Published: December 2024

The Chimica Techno Acta (CTA) journal was launched in 2014 by a recognized expert in organic chemistry, Prof. Yuri Morzherin, as a response to the various demands of scientists specializing in chemistry, chemical engineering, and materials science. Despite the existence of numerous chemical-related journals in Russia at the time, he believed that a new journal would serve as a platform for facilitating efficient regional communication among scientists, primarily students and postdoctoral researchers from Ural and related regions. Initially published in two languages (Russian and English) and two formats (print and online), CTA has garnered attention from its readership, then transforming gradually from a purely regional edition into the well-known Russian journal.
Results of various somatic mutations detection in patients with chronic myeloid leukemia
Authors: Kuzmina E. A. , Chelysheva E. Yu. , Biderman B. V. , Shukhov O. A. , Stepanova E. A. , Gadzhieva E. P. , Petrova A. N. , Nemchenko I. S. , Bykova A. S. , Guryanova M. A. , Kokhno A. V. , Turkina A. G. , Sudarikov A. B. 
Published: December 2024

Background. Somatic mutations in chronic myeloid leukemia (CML) patients are considered as possible factors for the failure of tyrosine kinase inhibitor (TKI) therapy, and the study of their characteristics is of interest.Aim. To evaluate the genetic profile of blood cells in CML patients using nextgeneration sequencing.Materials and methods. Retrospective study was conducted in two groups of patients: group 1 with TKI therapy failure (n = 29) and group 2 with optimal response to TKI therapy (n = 29). The target panel for nextgeneration sequencing included 19 genes: ASXL1, DNMT3A, FLT3, IDH1, IDH2, NPM1, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF2, KIT, WT1, CEBPA, ZRSR2, JAK2, GATA2, ABL1. In order to assess clonal evolution, additional samples were examined at a retrospective point in time closest to the primary CML diagnosis.Results. In group 1, mutations in 8 genes (including ABL1) were identified in 19/29 (66 %) patients. Excluding ABL1, mutations were identified in 15 (52 %) patients. In 9 (31 %) patients, >1 mutation (2 to 4) was detected. Frequency of genes mutations in group 1: ABL1 in 11 (38 %) patients, ASXL1 in 9 (31 %) patients, DNMT3A in 3 (10 %) patients, RUNX1, CEBPA in 2 patients (7 %), WT1, NPM1, TET2 in 1 patient (3.5 %). In 7 (24 %) patients there was a combination of mutations in ABL1 gene and in another gene; the most frequent combination of mutations in genes: ABL1 + ASXL1 – in 4 patients (14 %). The dynamics of mutant clones in group 1 was evaluated in 21/29 (72 %) patients. In 10/21 (48 %) patients somatic mutations in genes appeared during CML treatment, in 14/21 (67 %) patients previously detected mutations persisted, in 1 (5 %) the mutation disappeared. In group 2, somatic mutations were detected in 2/29 (7 %) patients: in DNMT3A (ariant Allele Frequency (AF) 5 %) and TP53 (AF 9 %) genes – these mutations were not detected at the diagnosis of CML. In one patient ASXL1 mutation (AF 5 %) was detected only at diagnosis, and was not detected subsequently with optimal response to therapy.Conclusion. The presence of somatic gene mutations is associated with a resistant CML course: somatic mutations in genes other than ABL1 were more common in CML patients with TKI therapy failure than in those with optimal response: 52 % vs. 7 % (p ≤0.05). Mutations in ASXL1 (31 %) and DNMT3A (10 %) were the most frequently detected. The frequency of ABL1 and ASXL1 mutations combination amounted to 14 %. uring followup, somatic mutations predominantly persisted or appeared over time in CML patients with TKI therapy resistance.
Gender and age characteristics of JAK2 V617F mutation allelic burden and CALR and MPL driver mutations detection during primary examination of patients with suspected myeloproliferative neoplasms
Authors: Olkhovskiy I. A. , Gorbenko A. S. , Stolyar M. A. , Bakhtina V. I. , Olkhovik T. I. , Martynova E. V. , Simonova O. S. , Nazhivin I. V. , Belkin D. N. 
Published: December 2024

Background. Detection of a somatic mutation in the Janus kinase 2 (JAK2) gene, along with mutations in the CALR and MPL genes, is one of the main criteria for diagnosing Ph-negative myeloproliferative neoplasms (MN). At the same time, the JAK2 617F mutation is often associated with agedependent clonal hematopoiesis of undetermined potential (CHI). As a rule, the indicator reflecting the number of blood cells transformed by mutation – the mutant allelic burden (MA) of JAK2 617F in CHI does not exceed 1–2 %, however, there is no clear boundary between the level of this indicator separating CHI and MN. The previously described “JAK2 paradox”, according to which JAK2 617F positive CHI predominates in men, and for women this mutation is more associated with MN, suggests a different attitude to the diagnostic value of MA between men and women. A separate issue concerns the detection of low MA levels in combination with other MN driver mutations.Aim. To analyze the database of JAK2 617F mutation allelic burden quantitative assessment results and to identify CALR and MPL genes driver mutations in patients depending on their age and gender.Materials and methods. Data from records on the age and gender of 6210 patients (3061 men and 3149 women) were analyzed, in whom the JAK2 gene 617F somatic mutation in a quantitative format and MPL and CALR genes mutations were simultaneously determined. Of these, mutations were identified in 1226 women and 826 men with symptoms of MN. Statistical analysis was performed using Excel spreadsheets and Statistica 10 package.The results. The data obtained indicate that in women, compared to men, the frequency of the 617F mutation is higher in all age ranges. omen are also more likely to have mutations in the CALR and MPL genes. The gender and age dependence of identifying quantitative values of MA JAK2 617F differ significantly in the range of >1 and ˂ 1%. Also noteworthy is the fact of high detection (up to 17–27 %) of additional combined mutations in the CALR and MPL genes in patients with low MA JAK2 617F values.Conclusion. The data support the gender “JAK2 paradox”, which suggests differential interpretation of test results in men and women. To more clearly assess the characteristics of the diagnostic value of MAN JAK2 617F low levels and its dependence on the gender and age of patients, controlled multicenter clinical studies using standardized diagnostic test systems are needed.
La responsabilidad del Estado por las promesas no cumplidas: ¿legalidad, confianza legítima, buena fe? Análisis desde el derecho administrativo francés y apuntes desde la experiencia colombiana
Authors: Aguilera Martín Mario Alejandro 
Published: December 2024

The regime for France's state liability for the administration's unfulfilled promises got consolidated in the middle of the last century. The administration is not allowed to make promises; these are considered irregular functioning administrative practices, mainly because of their incompatibility with the principle of non-disposability of competences, according to which, any authority vested with a competence must exercise it itself unless otherwise stated; thus, the administration cannot compromise its future action and discretional power to fulfil specific addressee results or benefits. In Colombia, this regime does not exist. However, in certain situations, the administration urges or pressure individuals to perform services without a formal contract, violating the contractual regulation, on the promise or assurance of a future formal contract.

This research addresses from a comparative law perspective the regime of unfulfilled promises in France, and similar cases of “promises” in Colombia. An analysis based on doctrine and jurisprudence, focusing especially on the legal bases used to establish the State’s liability. In France, such actions, may nevertheless give origin to the State's liability for 'service failure' [falla del servicio] in two cases when the administration does not honor its promises. Those two cases are when the promise is contrary to the law, and when the Administration decides not to fulfil the promise, breaching the legitimate expectations from the addressee, despite being able to do. In Colombia, until 2012, when the administration did not comply with the promise, the administrative judge protected the individual's good faith by recognizing unjust enrichment. Despite this, nowadays the priority is the protection of legality. Thus, the main objective of the investigation is to analyze the legal bases used in the two legal systems vis-à-vis this type of situation, concluding that they have been based, from different perspectives, on legality, legitimate expectations and good faith.
Recursos genéticos y recursos biológicos: una aproximación jurídica desde su rol en la biodiversidad como un interés tutelado
Authors: Vargas-Chaves Iván 
Published: December 2024

The paper analyzes the conceptual and regulatory frameworks for genetic and biological resources, as well as the State's responsibility for protecting biodiversity. Through a combined conceptual and legal approach, the author examines both types of resources and presents a comprehensive study on the appropriation of associated knowledge and derived products. The analysis focuses on the contract for access to genetic resources as an environmental management tool. Employing a systematic documentary analysis methodology, the paper interprets specific regulations (internal, supranational, and international) and relevant technical information.

This results in a comprehensive legal context for the appropriation of biological resources, associated knowledge, and products derived from genetic resources. The author concludes that challenges remain, including the ratification of the 2010 Nagoya Protocol and the need for improved capabilities, personnel, and infrastructure for resource management. Nevertheless, the contract for access to genetic resources offers a promising mechanism for contributing to effective global biodiversity conservation.
ASSOCIAÇÕES DE CATADORES DE MATERIAIS RECICLÁVEIS
Authors: Da Silva Rafael Mozart 
Published: December 2024

A reciclagem é uma estratégia fundamental na gestão de resíduos sólidos, que, entre outros benefícios, proporciona a redução da poluição, ajuda a preservar os recursos naturais, reduz a quantidade de resíduos destinados aos aterros, possibilita a inserção de catadores de materiais recicláveis no mercado de trabalho. A presente pesquisa teve como objetivos, demonstrar as práticas de reciclagem desenvolvidas por um grupo de associações de catadores, identificar os principais materiais reciclados e discutir os desafios e oportunidades para potencializar as atividades desenvolvidas pelos catadores de materiais recicláveis. Como resultado da pesquisa identificou-se a realização de um trabalho árduo, pois uma elevada parcela dos materiais coletados ainda se encontravam misturados e contaminados, o que acabava prejudicando e muito o processo de triagem e reciclagem. Observou-se também a falta de infraestrutura e equipamentos para realizar a reciclagem dos materiais. Constatou-se a necessidade de um maior reconhecimento e valorização dos catadores e catadoras de materiais recicláveis. O fomento e a criação de políticas públicas que possibilitem as práticas adequadas relacionadas a destinação de resíduos são urgentes e determinantes para um mundo mais sustentável, e as associações de reciclagem devem ser reconhecidas como agentes que desempenham um papel fundamental na coleta, seleção e destinação dos resíduos. Nesse sentido, torna-se oportuno a organização desses empreendimentos. Contudo, percebe-se também como contribuição desta pesquisa, os resultados do trabalho, os quais poderão ser utilizados como hipóteses para novas observações e aplicações que se têm acerca das atividades de reciclagem no Brasil
Características clínicas e prática de exercício físico de pacientes acometidos por COVID-19 atendidos em uma Clínica Escola
Authors: Castro Rafaella Pinheiro , Matos Felipe Antonio Gomes , Cruz Maria Roberta da Silva da , Teixeira Elizângela França , Braga Liana Raquel Rodrigues , Loura Pâmara Silva , Araújo Allanne Pereira , Barbosa Janaina Maiana Abreu 
Published: December 2024

Introdução: Com a pandemia do Sars-CoV-2, o isolamento social favoreceu o sedentarismo, fazendo com que os indivíduos deixassem de lado a prática de exercício físico, o que favoreceu as complicações clínicas daqueles que foram acometidos pela doença. Objetivo: Verificar as características clínicas e a prática de exercício físico de pacientes que tiveram COVID-19 atendidos em uma Clínica-Escola. Método: Estudo transversal realizado com 81 pacientes atendidos no setor de Nutrição de uma Clínica Escola que atende usuários do Sistema Único de Saúde (SUS). Foram incluídos pacientes de ambos os sexos, maiores que 19 anos e que apresentaram diagnóstico para COVID-19. Os dados foram coletados nos meses de janeiro a setembro de 2023. Todos os indivíduos foram submetidos ao preenchimento do questionário que avaliou os dados socioeconômicos, demográficos, clínicos e estilo de vida. Os dados foram analisados no programa Stata® versão 16.0. Resultados: Dos pacientes entrevistados, 81,48% eram do sexo feminino e 46,91% possuíam idade de 40 a 59 anos. Apenas 6,17% dos pacientes relataram ser assintomáticos, desses 60% faziam exercício físico. Observou-se que 49,38% apresentavam falta de ar como sintoma e que destes 67,50% não faziam exercício físico (p=0,003); Conclusão: A prática de exercício físico e o acometimento pela COVID-19 possui relação, aqueles que não possuíam esse hábito estavam mais suscetíveis ao quadro de sintomais.
A PRÁTICA INTERDISCIPLINAR NA ATENÇÃO PRIMÁRIA EM SAÚDE NO MUNICÍPIO DE PALMAS TO
Authors: Borges de Castro Leila 
Published: December 2024

O presente estudo tem como tema a Interdisciplinaridade na Política de Saúde Pública, mais especificamente na Atenção Primária em Saúde- APS com foco na atenção e no cuidado integral no Sistema Único de Saúde-SUS. Haja vista o histórico político, social e cultural em que à Política de Saúde foi concebida no Brasil, bem como os determinantes sociais que afetam as condições de vida e saúde das populações e suas implicações na atualidade e na forma como se dá a gestão do cuidado pela equipe multiprofissional na APS.

PALAVRAS-CHAVE: Interdisciplinaridade; Saúde; Política; Atenção; Cuidado; Integral.
Towards pandemic preparedness: ability to estimate high-resolution social contact patterns from longitudinal surveys
Authors: Dan Shozen , Tegegne Joshua , Chen Yu , Ling Zhi , Jaeger Veronika , Karch André , Mishra Swapnil , Ratmann Oliver 
Published: December 2024

Abstract

Social contact surveys are an important tool to assess infection risks within populations, and the effect of non-pharmaceutical interventions on social behaviour during disease outbreaks, epidemics, and pandemics. Numerous longitudinal social contact surveys were conducted during the COVID-19 era, however data analysis is plagued by reporting fatigue, a phenomenon whereby the average number of social contacts reported declines with the number of repeat participations and as participants' engagement decreases over time. Using data from the German COVIMOD Study between April 2020 to December 2021, we demonstrate that reporting fatigue varied considerably by sociodemographic factors and was consistently strongest among parents reporting children contacts (parental proxy reporting), students, middle-aged individuals, those in full-time employment and those self-employed. We find further that, when using data from first-time participants as gold standard, statistical models incorporating a simple logistic function to control for reporting fatigue were associated with substantially improved estimation accuracy relative to models with no reporting fatigue adjustments, and that no cap on the number of repeat participations was required. These results indicate that existing longitudinal contact survey data can be meaningfully interpreted under an easy-to-implement statistical approach adressing reporting fatigue confounding, and that longitudinal designs including repeat participants are a viable option for future social contact survey designs.
The Ambiguity of 'Balanced Neighbourhoods': How Rotterdam’s Housing Policy Undermines Urban Social Resilience
Authors: Prieto-Viertel Guillermo , Sirenko Mikhail , Benitez-Avila Camilo 
Published: December 2024

Abstract

Over the past decade, cities worldwide have increasingly adopted urban social resilience strategies, implementing systemic approaches to foster collective action and solidarity while considering the nuances of urbanisation. Their implementation, however, not only often prevents a clear assessment of the impact on resilience but also provides a fertile ground for cherry-picking, where ambiguous indicators can obscure the true drivers for urban renovation. This study examines the relationship between the "balanced neighbourhood" concept based on property value as defined by Rotterdam’s municipal policy and its contribution to urban social resilience. We use empirical data and structural equation modelling to investigate the relationship between property value distribution, social cohesion, and informal support in "balanced neighbourhood" configurations. Our findings reveal that only 2.1% of the possible property value configurations fit the research model underneath Rotterdam’s urban policy claims on social cohesion and informal support, and even in these cases, the associations are counterproductive. We argue that the ambiguous definition of "balanced neighbourhoods" obscures policy goals with certain areas, particularly in the North, paradoxically meeting policy conditions without showing the municipality’s long-term target composition, whereas the South, with a higher concentration of social housing, is targeted for renovation/demolition plans. Our study highlights the need for more nuanced and accurate measurement tools to assess social resilience and calls for a shift in focus from interventions that alter the physical composition of neighbourhoods to focusing on enhancing social cohesion as a key factor promoting resilient actions.
Associations Between Structural Stigma and Advanced Pubertal Development Persist for One Year Among Black Girls and Latinx Youth
Authors: Martino Rachel , Hollinsaid Nathan , Colich Natalie , McLaughlin Katie , Hatzenbuehler Mark 
Published: December 2024

Abstract

Black and Latinx youth experience advanced pubertal development relative to their same-aged, non-stigmatized peers. Research on determinants of this increased risk has focused almost exclusively on aspects of individuals (e.g., body-mass index) or their proximal environment (e.g., socioeconomic status), to the exclusion of broader macro-social factors. Using two years of Adolescent Brain Cognitive Development Study® data, we examined whether structural stigma (e.g., state-level policies, aggregated prejudicial attitudes) was associated with hormonal and perceived physical indicators of pubertal development. Baseline results documented more advanced pubertal development among Black girls (hormones) and Latinx youth (youth and/or caregiver report) in states characterized by higher (vs. lower) structural stigma. Observed associations were comparable in effect size to a well-established correlate of pubertal development, BMI, and remained or strengthened one year later among these stigmatized (vs. non-stigmatized) groups. Findings suggest the need to broaden the study of determinants of pubertal development to include macro-social factors.
“Assessment of the utilization of fresh frozen plasma in a training and research hospital: What does the high level of inappropriate use tell us?” A descriptive-analytical study with cross-sectional method.
Authors: Yazici Murat , Yilmaz Soner , Gokcebay Dilek Gurlek , Kaymak Sahin , Yilmaz Esra Safak , Yakut Ulas , Arslan Gokhan , Avci İsmail Yasar 
Published: December 2024

Abstract

Objective: Fresh frozen plasma (FFP) is a life-saving treatment agent when used correctly, but it is also the one which is the most inappropriately used among the blood components. The aim of this study is to evaluate FFP transfusion indications based on different clinics.
Methods: The study was carried out with the data obtained as a result of retrospective reviewing of the data of a total of 500 patients from 10 different clinics. FFP Transfusion Evaluation Form was created after scanning national/international articles, guidelines, and similar publications regarding the use of FFP.
Results: It was determined that FFP was used at a rate of 26.6 % within appropriate indications. In terms of mortality development, there was no difference between the indication groups (p=0,31). There was no difference between the indication groups in the number of cases in which INR decreased with FFP transfusion (p=0,14). While the mean aPTT levels decreased from 48,2±32,1 to 31±15,4 (p<0,01) after transfusion, the mean INR values decreased from 3,6±3,8 to 1,6±0,8 (p< 0,04).
Conclusion: The high rate of inappropriate use of FFP both threatens patient health due to transfusion reactions and affects stock management in blood centers adversely. The results obtained from the study reveal that standards and guidelines should be established for the appropriate use of FFP, both on a hospital and hospital basis, and the process should be audited at regular intervals in terms of ensuring clinicians' compliance with them and appropriate use.