bluuebunny/crossref_metadata_2025_split huggingface dataset:
P0737THE ASSOCIATION BETWEEN CYSTATIN C AND ARTERIAL STIFFNESS IN NON-CKD PATIENTS
Authors: Piko Nejc , Petreski Tadej , Ekart Robert , Hojs Radovan , Bevc Sebastjan 
Published: June 2020

Abstract

Background and Aims
Serum cystatin C (cysC) is produced by all nucleated cells at a constant rate, is filtered freely by the glomerulus and metabolized after tubular reabsorption. It is influenced less by age, gender and muscle mass compared to serum creatinine. These properties make it an important marker in detecting renal impairment. Arterial stiffness is a hallmark of atherosclerosis and is connected to cardiovascular events and mortality. In patients with chronic kidney disease (CKD), cysC correlates with increased arterial stiffness, but less is known about the association between cysC and arterial stiffness in non-CKD patients.

Method
The study was performed at the University Medical Centre Maribor between October 1st 2018 and January 1st 2020. Basic demographic and laboratory data were recorded. To estimate glomerular filtration rate (eGFR), Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used. Patients with previously diagnosed CKD and/or eGFR ≤ 60 ml/min/1.73m2 at the time of admission, known malignancy, thyroid disease and/or on steroid therapy were not enrolled in the study. Arterial stiffness was measured with applanation tonometry (Sphygmocor®, Australia), carotid-femoral pulse wave velocity (cfPWV) was used as the gold standard of central arterial stiffness and subendocardial viability ratio (SEVR) was used as the marker of myocardial perfusion. SPSS® version 22 was used for statistical analysis.

Results
111 patients (65.8% male, average age 64.3±9.4 years) were included in our study. Most common comorbidities were arterial hypertension (n=86, 77.5%), hyperlipidaemia (n=64, 57.7%) and diabetes mellitus (n=22, 19.8%). Mean creatinine value was 77.7±13.8 μmol/L (range 49-108 μmol/L), mean eGFR was 81.3±9.4 ml/min/1.73m2 (range 62-90 ml/min/1.73m2) and mean value of cysC was 0.94±0.18 mg/L (range 0.67-1.63 mg/L). Mean SEVR value was 165.7±36.1% (range 92-299%) and mean cfPWV value was 10.1±2.4 m/s (range 6.2-16.8 m/s). Significant correlation was found between cysC and SEVR (r=-0.316, p&lt;0.001) and between cysC and cfPWV (r=0.472, p&lt;0.001). Multiple regression analysis of arterial stiffness indices and cysC, age, gender, diabetes mellitus, arterial hypertension, eGFR and hyperlipidemia, showed statistically significant association between cysC and cfPWV (ß=0.220, p=0.038) and cysC and SEVR (ß=-0.278, p=0.017).

Conclusion
Serum cysC is independently associated with increased arterial stiffness, reduced myocardial perfusion and increased cardiovascular risk in non-CKD patients.
P0741CHRONIC KIDNEY DISEASE PROGRESSION IN A LARGE PREVENTION COHORT IN COLOMBIA
Authors: Rivera Angela , Bernardo Angelito , Vesga Jasmin , Ronderos Izcay , Sanabria Mauricio 
Published: June 2020

Abstract

Background and Aims
Chronic kidney disease (CKD) is a syndrome that today has important implications for the health of populations and the economic sustainability of health systems around the world, therefore strategies to slow disease progression are necessary.
Aims: To estimate the incidence of renal replacement therapy (RRT) in a cohort of patients included in a CKD secondary prevention program and to describe the decrease of the estimated glomerular filtration rate (eGFR).

Method
This is a historical, multicenter, observational cohort study in a prevention program between January 1, 2010, and December 31, 2017, with follow-up until December 31, 2018, at the Renal Care Services (RCS) network. Socio-demographic and clinical characteristics of all patients were summarized descriptively. We estimated the incidence of RRT rate with Kaplan Meier analysis. Progression rate to RRT was analyzed by mixed-effects model adjusted for the eGFR reduction rate at 180 days; the model considered the diagnosis of diabetes.

Results
7131 patients met the inclusion criteria for data analysis. The mean age was 65 years, 50.5% were female, (Table 1). There were 577 events of RRT with a rate of 2.02 events of RRT per 100 patients-year [95% CI,1.86 to 2.19], characteristics at the RRT initiation are presented in Table 2. At the beginning of the program the eGFR was 45.3 ml / min / 1.73m2 in non-diabetics, and 40.9 3 ml / min / 1.73m2 in diabetics. The CKD progression was - 0.48 ml / min / 1.73m2 per 180 days in diabetics and - 0.20 ml / min / 1.73m2 per 180 days in non-diabetics. The final events of the cohort are presented in Figure 1; the mortality rate was 0.89 events per 100 patients-year [95% CI, 0,79 to 1,01].

Conclusion
This population of patients in a CKD prevention program presented a low rate of initiation of dialysis therapy and a slight decrease of eGFR; the diabetic status influences the CKD progression.
P0743COMPARISON OF PROTEINURIA LEVELS BETWEEN PROFESSIONAL AND RECREATIONAL CROSSFIT ATHLETES
Authors: Diniz Renan , De Francesco Daher Elizabeth , Bezerra da Silva Junior Geraldo , Nunes Filho Julio Cesar Chaves , Nunes Marilia Porto Oliveira 
Published: June 2020

Abstract

Background and Aims
High intensive sports athletes are under risk of muscular injuries and likely renal damage secondary to it. As CrossFit is becoming more popular in last years, few consistent studies are available evaluating renal damage associated to this sport. The purpose of this study was to compare proteinuria levels between recreational and professional CrossFit athletes who were under training for a local competition.

Method
These athletes were invited to answer a survey. After this step, they were submitted to proteinuria analysis through urine dipstick reading. They also were divided into two groups (professional X recreational athletes) and the results were compared using chi-square test.

Results
A total of 99 athletes have concluded all the steps of the study. Among professional athletes, age average was 34.1 +3.9 year old, body mass index (BMI) 27.14 + 3.14 kg/m2 while in the recreational group the age average was 28.7 + 5.9 and BMI 26.49 + 4.56 kg/m2. Comparing proteinuria analysis, 44.4% of professional group have shown levels between 300 and 1000mg/dL and 14.8% have reached levels above 1000mg/dL, while only 2.8% among recreational ones have reached levels above 300mg/dL (p=0.001) with no one in this groups showing levels &gt; 1000mg/dL.

Conclusion
This study has shown high proteinuria levels among professional CrossFit athletes comparing to recreational ones. As the literature is scarce in showing long-term kidney damage among CrossFit athletes, epidemiological studies warn about likely kidney damage related to this practice, a fact that can suggest better medical follow-up for CrossFit athletes.
P0744CLINICAL IMPACT OF SERUM INDOXYL SULPHATE MEASURED BY NEW ENZYMATIC METHOD IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Yasuda Yoshinari , Kikuchi Ryosuke , Goto Kazunori , Kaihan Ahmad Baseer , Kato Sawako , Maruyama Shoichi 
Published: June 2020

Abstract

Background and Aims
Uremic toxins have been highlighted as serious risk factors for deterioration of renal function and onset/progression of cardiovascular diseases (CVD). Serum level of indoxyl sulphate (IS), a major uremic toxin, was demonstrated its significant association with vascular disease and mortality in a cohort of chronic kidney disease (CKD) patients, however, IS has not been available in clinical setting due to time consuming and expensive measurement cost. Recently epoch-making IS measurement method applicable for general auto analyzer has been developed, which could explore new therapeutic avenue in CKD from the view point of uremic toxin management.
In this study, clinical utility of new enzymatic IS measurement method was analyzed in association with renal function and CVD among CKD patients.

Method
Subjects were consecutive 150 CKD patients in Nagoya University Hospital whose serum samples were collected between 2009 and 2014. Serum IS levels were measured by “NIPRO” reagent and analyzed with eGFR, CVD events and renal outcomes defined by 30% decrease in eGFR.

Results
Characteristics of patients were 69 ± 10 years old, 29% female, eGFR: 44 ± 20 mL/min/1.73m2 (∼G3a: 43％, G3b: 29％, G4: 24％, ï¼§5: 4％), proteinuria 2.8 ± 3. 5ï½‡/ï½‡Cr (A1: 29％, A2: 29％, A3: 42％), HTN: 83％, and DM: 39％. Serum IS levels (μmol/L) were 10.5 ± 7.5 (∼G3a: 1.8 ± 0.6, G3b: 2.1 ± 0.6, G4: 15.8 ± 8.1, ï¼§5: 22.9 ± 13.5), and strongly correlated with eGFR (r =0.518, P&lt;0.001). Among IS low (&lt;6), middle and high (≥12) tertiles, significantly different factors were age, eGFR, Hb, iPTH and LDL-C. In multiple logistic regression analysis, only eGFR was significant associating factor with IS tertiles. IS levels in 2 patients prescribed AST-120 (Kremezin) were 8.1 and 10.3, which seems to be very low in comparison to their eGFR of 13.8 and 13.7. During observation period of 5.1 ± 1.0 years, 59 renal outcomes and 9 CVD events were observed. Kaplan-Meier survival curve analysis free from renal outcomes revealed better tendency in IS low group (p= 0.0617 in log-rank test). According to IS levels adjusted by eGFR, only 1 out of 9 CVD events occurred in low IS/eGFR tertile group.

Conclusion
Serum IS levels could be measured in new enzymatic method. Strong correlation between IS and eGFR was demonstrated, and AST-120 might be effective to improve IS. In renal and CVD outcome analysis, more sample size is needed for further study.
P0756THE RELATIONSHIP BETWEEN ABDOMINAL AORTIC CALCIFICATION AND PROGRESSION OF RENAL INSUFFICIENCY IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: KIM SO MI , Cho Jong Tae , Jeon Ji Hyun , Lee Yong-Moon , Lee Eun Kyoung , Lee Hwa Young 
Published: June 2020

Abstract

Background and Aims
Although abdominal aortic calcification (AAC) is known to be associated with cardiovascular mortality in patients with chronic kidney disease (CKD), there are little information about the impact of AAC on progression of CKD. Therefore, we investigated the relationship between the AAC and progression of renal insufficiency in CKD patients with early stage.

Method
A total of 183 patients with CKD, stage 3 was included. The degree of AAC was evaluated by computed tomography and the score was calculated as follows: abdominal calcification index (ACI)= (total score of calcification on all slices)/12 × 1/(number of slices) × 100%. Based on tertile of ACI, the patients were divided into three groups: low-, intermediate-, and high-groups. The annual decline of glomerular filtration rate (GFR) and time to dialysis were assessed.

Results
The AAC was found (ACI &gt; 0) in 129 patients (70.4%), and the mean ACI was 21.3 %. The average duration of follow-up was 46.9 months. The high ACI group showed higher annual decline in GFR compared to other groups (27.8 vs 14.5 vs 11.3 mL/min, p=0.042). During the follow-up, 68.8% (42/61) of high ACI group received dialysis and the time to dialysis was significantly shorter than other groups (14.8 vs. 25.8 vs.29.1 months, p=0.038)

Conclusion
In this study, we showed the AAC was associated with rapid progression of CKD. Evaluation of the AAC in CKD with early stage provides useful information for predicting the progression of CKD.
P0757THO ROLE OF MARKERS TO ASSESS RISK FOR DEVELOPING CARDIORENAL SYNDROME
Authors: Tasic Danijela , Radenkovic Sonja , Kocic Gordana , Poskurica Mileta , Stojanovic Dijana 
Published: June 2020

Abstract

Background and Aims
Biomarkers are circulating proteins and metabolites, which are released in the body fluids from the damaged organ or tissue is detected specific essays and plays a role in the diagnosis, evaluation and monitoring of patients. Today there is a large number of markers that assess the intensity of pro-inflammatory and oxidative processes in the cardio-renal syndrome, whose determination would have great diagnostic and prognostic significance. The aim of our investigation was to identifying which of the examined parameters stand out as independent risk factors for the development of the cardiorenal syndrome (CRS).

Method
The study included 114 subjects older than 18 years, of both sexes, divided into clinical and control group. The control group was consisted of 35 healthy males and females with similar characteristics as well as clinical groups. The clinical group was consisted of 79 patients: 40 (50.63%) male and 39 (49.37%) female, mean age of 70.72 ± 9.26 years, diagnosed on the basis of the current classification of cardiorenal syndrome. The respondents were familiar with the case studies and signed informative consent. The study was approved by the Ethics Committee and conducted in compliance with the Helsinki Declaration on Medical standards of Good Clinical Practice.

Results
With correlation analysis of examined biomarkers in respondents of the clinical group was established positive correlation between plasma BNP and IL-8 (r = 0.383, p = 0.006), BNP and cTnhsT (r = 0.518, p = 0.001) BNP and cystatin C (r = 0.447, p = 0.001) and BNP and CRP (r = 0.306, p = 0.046), while a negative correlation was observed between the BNP and the activities of MDA (r = - 383, p = 0.007). Negative correlations were also between the activity of the MDA and the IL-8 concentration (r = -0.237, p = 0.038), and MDA cTnhsT (r = -0.321, p = 0.009) and MDA and cystatin C (r = -0.315, p = 0.005 ). XOD activity cost was positively correlated with the XD (r = 0.942, p &lt;0.001), and the activity of XO was positively associated with TnI (r = 0.522, p = 0.009) and negatively correlated with the XD (r = -0.423, p &lt;0.001 ). The concentration of IL-8 was positively associated with cTnhsT concentrations (r = 0.427, p &lt;0.001) and with concentrations of CRP (r = 0.411, p = 0.001), the concentration of PAI-1 with cTnhsT concentration (r = 0.558, p &lt;0.001), with TnI concentration cTnhsT (r = 0.852, p &lt;0.001), and cTnhsT with cystatin C (r = 0.338, p = 0.006) and CRP (r = 0.358, p = 0.011). Cystatin C stood positively related to the concentration of CRP (r = 0.510, p &lt;0.001).

Conclusion
Early detection of occurrence of functional and structural damage to the heart and kidneys, highly sensitive and specific markers would enable not only their discovery, but also prevention and treatment.
P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?
Authors: Reis Marina Sofia Rodrigues , Salvador Pedro , Gomes Ana Marta , Beça Sara , Fernandes João Carlos 
Published: June 2020

Abstract

Background and Aims
Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients.

Method
A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months.

Results
The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890).

Conclusion
Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients.
P0773ESTIMATING THE BURDEN OF CHRONIC KIDNEY DISEASE (CKD) IN THE UK: COMPARISON OF TWO HEALTH ECONOMIC POLICY ANALYSIS METHODS
Authors: Garcia Sanchez Juan Jose , Xu Michael , Sörstadius Elisabeth , Darlington Oliver , McEwan Phil , Lande Simon , Pearson-Stuttard Jonathan , Webber Laura 
Published: June 2020

Abstract

Background and Aims
Chronic kidney disease (CKD) represents an important health policy concern due to a growing population and its associated morbidity and mortality. Predicting the future burden of CKD overall and in high-risk populations such as patients with elevated albuminuria, type 2 diabetes (T2D) or heart failure (HF) is important if healthcare services are to be resourced properly. Health economic policy models based on epidemiological and clinical outcomes data provide a useful way by which to make such predictions; different methods of varying complexity have been employed to do this. This study aims to compare two different analytical approaches to estimating the burden of CKD in the UK, and to estimate how this is predicted to change in the future.

Method
Analysis 1 and 2 characterised the prevalent and incident CKD population, disease progression, clinical outcomes, costs and quality of life sourced from published data over a 5-year horizon.
Analysis 1 utilised an open cohort analysis based on a Markov framework, with health states defined by CKD stages. Disease progression was modelled through the application of published estimates of the rate of estimated glomerular filtration rate (eGFR) decline, stratified by the presence of T2D, HF and albuminuria.

Results

Conclusion
P0774KIDNEY FUNCTION, KIDNEY FUNCTION DECLINE AND THE RISK OF ALL CAUSE, VASCULAR AND ALZHEIMER'S DEMENTIA: THE STOCKHOLM CREATININE MEASUREMENTS (SCREAM) PROJECT
Authors: Xu Hong , Trevisan Marco , Evans Marie , Lindholm Bengt , Carrero Juan Jesus 
Published: June 2020

Abstract

Background and Aims
Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk are conflicting. In this large Swedish population-based cohort, we explore the links between kidney function, kidney function decline and dementia incidence.

Method
In the Stockholm CREAtinine Measurements (SCREAM) project, we studied the association of baseline eGFR with the risk of incident dementia among 329,822 residents of Stockholm who accessed healthcare, were ≥65 years and had no previous history of dementia. We estimated the rate of eGFR decline among the 205,622 residents with repeated eGFR measurements during the first year and investigated its association with dementia risk. The primary outcome was dementia incidence based on ICD-10 codes or use of anti-dementia drugs. Secondary outcomes were incidence of the dementia subtypes Alzheimer’s and vascular dementia.

Results
18,983 cases of dementia (5.8% of participants) were detected throughout 1,185,304 person-years. Dementia incidence rates (IR) were progressively higher with lower eGFR: from 6.56/1000 person-years in persons with eGFR 90-104 ml/min to 30.28/1000 person-years in those with eGFR&lt;30 ml/min). Compared with eGFR of 90-104 ml/min, lower eGFR was associated with a higher dementia risk [adjusted hazard ratio (HR), 1.69; 95% confidence interval (CI], 1.52-1.89 in eGFR 30-59 ml/min and HR 2.55, 1.86-3.50 in eGFR&lt;30 ml/min). A steeper decline in eGFR within one year was linearly associated with higher dementia risk for declines greater than 2ml/min/1.73 m2/year. Risk magnitudes were stronger for vascular dementia than for Alzheimer. Sensitivity analyses across predefined strata or after excluding early events yielded similar results. As many as 11% (95% CI 7-14%) of dementia cases were attributed to chronic kidney disease (eGFR&lt;60 mL/min/1.73m2), a proportion higher than that attributed to other dementia risk factors such as cardiovascular disease and diabetes.

Conclusion
In the general population, both low kidney function and faster kidney function decline are associated with increased risk of developing dementia, particularly vascular dementia.
P0778INVESTIGATION THE EFFECT OF SERUM URIC ACID ON NEW-ONSET AND PROGRESSION OF CHRONIC KIDNEY DISEASE(CKD) IN JAPANESE GENERAL POPULATION : IKI EPIDEMIOLOGICAL STUDY OF ARTHEROSCLEROSIS AND CHRONIC KIDNEY DISEASE(ISSA-CKD) RETROSPECTIVE PHASE
Authors: Tada Kazuhiro , Maeda Toshiki , Takahashi Koji , Ito Kenji , Yasuno Tetsuhiko , Mukoubara Shigeaki , Masutani Kosuke , Arima Hisatomi , Nakashima Hitoshi 
Published: June 2020

Abstract

Background and Aims
Chronic kidney disease is one of the most urgent public health issue in Japan as well as other countries. Many risk factors for development and progression of CKD have been recognized, such as hypertension, diabetes, obesity. However, it is still unclear whether increase of serum uric acid has negative impact on kidney function. The aim of this study is to investigate how serum uric acid influences the new-onset and progression of CKD in Japanese general population.

Method
The Iki epidemiological Study of atherosclerosis And Chronic Kidney Disease (ISSA-CKD) is a population-based retrospective cohort study using annual health check-up data in the Iki Island (Nagasaki Prefecture, Japan), which has approximately 27,000 residents. A total of 7,645 residents underwent annual health check-ups from fiscal year 2008 to 2016. After excluding residents who visited only 1 health check-up and those with missing information of serum creatinine or serum uric acid, a total of 5507 adults were included in the present analysis. The outcome of the present analysis was new-onset of CKD (reduction in estimated glomerular filtration rate [eGFR] less than 60mL/min/1.73m2 or development of proteinuria among participants without CKD at baseline) and CKD progression (worsening of the stages of eGFR or proteinuria according to the KDIGO guideline among participants with CKD at baseline).

Results
During a mean follow-up of 4.6 years, 757 (16.7%) new-onset CKD and 193 (19.7%) progression of CKD were observed. Serum uric acid had significant relationship with new-onset CKD even after adjustment for sex, age, obese, hypertension, dyslipidemia, and diabetes mellitus: hazard ratio 1.14 per 1 mg/dL increase, 95% confidence interval 1.07-1.21, P&lt;0.001). On the other hand, serum uric acid did not have significant relationship with CKD progression: hazard ratio 1.08 per 1 mg/dL increase, 95% confidence interval 0.96-1.21, P=0.190). Similar results were observed for hyperuricemia defined as serum uric acid level ≥7mg/dl.

Conclusion
The findings of the present analysis show that serum uric acid was significantly associated with increased risks of new onset of CKD, but was not associated with progression of CKD in Japanese general population.