bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-22 mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury
Authors: Chen Wei , Shen Yilan , Fan Jiajun , Zeng Xian , Zhang Xuyao , Luan Jingyun , Zhang Jinghui , Fang Si , Mei Xiaobin , Ju Dianwen 
Published: August 2020

AbstractKidney damage initiates the deteriorating metabolic states in tubule cells that lead to the development of end-stage renal disease (ESTD). Interleukin 22 (IL-22) is an effective therapeutic antidote for kidney injury via promoting kidney recovery, but little is known about the underlying molecular mechanisms. Here we first provide evidence that IL-22 attenuates kidney injury via metabolic reprogramming of renal tubular epithelial cells (TECs). Specifically, our data suggest that IL-22 regulates mitochondrial function and glycolysis in damaged TECs. Further observations indicate that IL-22 alleviates the accumulation of mitochondrial reactive oxygen species (ROS) and dysfunctional mitochondria via the induction of AMPK/AKT signaling and PFBFK3 activities. In mice, amelioration of kidney injury and necrosis and improvement of kidney functions via regulation of these metabolism relevant signaling and mitochondrial fitness of recombinant IL-22 are certificated in cisplatin induced kidney damage and diabetic nephropathy (DN) animal models. Taken together, our findings unravel new mechanistic insights into protective effects of IL-22 on kidney and highlight the therapeutic opportunities of IL-22 and the involved metabolic regulators in various kidney diseases.
RIPK3 facilitates host and pathogen interactions after oralToxoplasma gondiiinfection
Authors: Cervantes Patrick W. , Knoll Laura J. 
Published: August 2020

AbstractToxoplasma gondiiinfection activates pattern recognition receptor (PRR) pathways that drive innate inflammatory responses to control infection. Necroptosis is a pro-inflammatory cell death pathway apart of the innate immune response that has evolved to control pathogenic infection. In this study we further defined the role of Z-DNA binding protein 1 (ZBP1) as a PRR and assessed its contribution to necroptosis as a host protection mechanism toT. gondiiinfection. We found that ZBP1 does not induce pro-inflammatory necroptosis cell death and ZBP1 null mice have reduced survival after oralT. gondiiinfection. In contrast, mice deleted in receptor-interacting serine/threonine-protein kinase 3 (RIPK3-/-), a central mediator of necroptosis, have significantly improved survival after oralT. gondiiinfection even with higher parasite burden. The physiological consequences of RIPK3 activity did not show any differences in intestine villi immunopathology but RIPK3-/-mice showed higher immune cell infiltration and edema in the lamina propria. The contribution of necroptosis to host survival was clarified with mixed lineage kinase domain like pseudokinase null (MLKL-/-) mice. We found MLKL-/-mice to succumb to oralT. gondiiinfection the same as wild type mice, indicating necroptosis-independent RIPK3 activity impacts host survival. These results provide new insights on the impacts of pro-inflammatory cell death pathways as a mechanism of host defense to oralT. gondiiinfection.
Making the case for virtual competency-based education
Authors: Cates Steven Vaughn , Doyle Sean , Gallagher Lisa , Shelton Gary , Broman Noel , Escudier Blake 
Published: August 2020

PurposeThe purpose of this paper is to present a competency-based curriculum design model based on a set of ten foundational professional competencies (PCs) that prepare college graduates to meet the needs of global businesses now and in the future.Design/methodology/approachThis phenomenological single-case study reviews literature on the foundational principles of competency-based education (CBE) and comparatively analyzes the results of qualitative interviews to create a set of ten PCs linking employee and business success.FindingsThis study presents a theoretical competency-based curriculum model (competency-based learning, performance and behavior (CBLPB)) designed for online education programs to enable a twenty-first century workforce to succeed. The curriculum design model is tested as applied by the researchers in various courses taught at an online university.Research limitations/implicationsThis is a conceptual model for testing in academic research settings in colleges and universities.Practical implicationsThe study suggests that higher education business curriculum should be designed using a CBE model to develop graduates with the foundational PCs that employers need and desire in educated working professionals.Originality/valueFrom the faculty perspective, the CBLPB curriculum design model can enhance the design and implementation of CBE in business programs.
Corporate social responsibility and idiosyncratic risk in the restaurant industry: does brand diversification matter?
Authors: Ozdemir Ozgur , Erkmen Ezgi , Kim Minji 
Published: August 2020

PurposeThis study aims to examine the link between corporate social responsibility (CSR) and idiosyncratic risk in the restaurant industry. The study also explores whether brand diversification magnifies the risk reduction effect of CSR in the restaurant industry.Design/methodology/approachThe study uses an unbalanced panel of 274 firm-year observations for 43 restaurant firms over the period 1995–2015. Models are estimated via fixed effect regression with robust standard errors.FindingsThe study finds that CSR involvement reduces idiosyncratic risk and this risk reduction is intensified when restaurant firms operate a portfolio of brands.Research limitations/implicationsThe study’s findings are limited to restaurant industry, therefore, generalization of the findings to other industries requires delicate care. Brand diversification is a simple brand count due to a lack of brand sales data.Practical implicationsCSR activities are not cost burden for restaurant firms. Indeed, CSR could be a viable strategy to reduce the volatility in future expected cash flows, hence the idiosyncratic risk. This risk reduction could help owners/managers access to capital with lower cost. Moreover, the study suggests that CSR practices should not be implemented in isolation from firm marketing strategy such as portfolio of brands.Originality/valueAlthough prior hospitality research puts forth some evidence using systematic risk as the measure of firm risk, this measure may not best suit the purpose in CSR context given that CSR is a direct, firm-specific strategy. Hence, the current study provides both new evidence with firm-specific, idiosyncratic risk and introduces an important contingency situation when the risk reduction effect of CSR would become more profound for restaurant firms.
An end-to-end deep source recording device identification system for Web media forensics
Authors: Zeng Chunyan , Zhu Dongliang , Wang Zhifeng , Wang Zhenghui , Zhao Nan , He Lu 
Published: August 2020

Purpose
Most source recording device identification models for Web media forensics are based on a single feature to complete the identification task and often have the disadvantages of long time and poor accuracy. The purpose of this paper is to propose a new method for end-to-end network source identification of multi-feature fusion devices.

Design/methodology/approach
This paper proposes an efficient multi-feature fusion source recording device identification method based on end-to-end and attention mechanism, so as to achieve efficient and convenient identification of recording devices of Web media forensics.

Findings
The authors conducted sufficient experiments to prove the effectiveness of the models that they have proposed. The experiments show that the end-to-end system is improved by 7.1% compared to the baseline i-vector system, compared to the authors’ previous system, the accuracy is improved by 0.4%, and the training time is reduced by 50%.

Research limitations/implications
With the development of Web media forensics and internet technology, the use of Web media as evidence is increasing. Among them, it is particularly important to study the authenticity and accuracy of Web media audio.

Originality/value
This paper aims to promote the development of source recording device identification and provide effective technology for Web media forensics and judicial record evidence that need to apply device source identification technology.
Tactile Enumeration and Embodied Numerosity Among the Deaf
Authors: Hochman Shachar , Cohen Zahira Z. , Ben‐Shachar Mattan S. , Henik Avishai 
Published: August 2020

AbstractRepresentations of the fingers are embodied in our cognition and influence performance in enumeration tasks. Among deaf signers, the fingers also serve as a tool for communication in sign language. Previous studies in normal hearing (NH) participants showed effects of embodiment (i.e., embodied numerosity) on tactile enumeration using the fingers of one hand. In this research, we examined the influence of extensive visuo‐manual use on tactile enumeration among the deaf. We carried out four enumeration task experiments, using 1–5 stimuli, on a profoundly deaf group (n = 16) and a matching NH group (n = 15): (a) tactile enumeration using one hand, (b) tactile enumeration using two hands, (c) visual enumeration of finger signs, and (d) visual enumeration of dots. In the tactile tasks, we found salient embodied effects in the deaf group compared to the NH group. In the visual enumeration of finger signs task, we controlled the meanings of the stimuli presentation type (e.g., finger‐counting habit, fingerspelled letters, both or neither). Interestingly, when comparing fingerspelled letters to neutrals (i.e., not letters or numerical finger‐counting signs), an inhibition pattern was observed among the deaf. The findings uncover the influence of rich visuo‐manual experiences and language on embodied representations. In addition, we propose that these influences can partially account for the lag in mathematical competencies in the deaf compared to NH peers. Lastly, we further discuss how our findings support a contemporary model for mental numerical representations and finger‐counting habits.
Towards a systematics of ecodiversity: The EcoSyst framework
Authors: Halvorsen Rune , Skarpaas Olav , Bryn Anders , Bratli Harald , Erikstad Lars , Simensen Trond , Lieungh Eva 
Published: August 2020

AbstractBackgroundAlthough a standard taxonomy of organisms has existed for nearly 300 years, no consensus has yet been reached on principles for systematization of ecological diversity (i.e., the co‐ordinated variation of abiotic and biotic components of natural diversity). In a rapidly changing world, where nature is under constant pressure, standardized terms and methods for characterization of ecological diversity are urgently needed (e.g., to enhance precision and credibility of global change assessments).AimThe aim is to present the EcoSyst framework, a set of general principles and methods for systematization of natural diversity that simultaneously addresses biotic and abiotic variation, and to discuss perspectives opened by this framework.InnovationEcoSyst provides a framework for systematizing natural variation in a consistent manner across different levels of organization. At each ecodiversity level, EcoSyst principles can be used to establish: (a) an extensive attribute system with descriptive variables that cover all relevant sources of variation; (b) a hierarchical‐type system; and (c) a set of guidelines for land‐cover mapping that is consistent across spatial scales. EcoSyst type systems can be conceptualized as multidimensional models, by which a key characteristic (the response) is related to variation in one or more key sources of variation (predictors). EcoSyst type hierarchies are developed by a gradient‐based iterative procedure, by which the “ecodiversity distance” (i.e., the extent to which the key characteristic differs between adjacent candidate types) is standardized and the ecological processes behind observed patterns are explicitly taken into account.ApplicationWe present “Nature in Norway” (NiN), an implementation of the EcoSyst framework for Norway for the ecosystem and landscape levels of ecodiversity. Examples of applications to research and management are given.ConclusionThe EcoSyst framework provides a theoretical platform, principles and methods that can complement and enhance initiatives towards a global‐scale systematics of ecodiversity.
Infants’ responsiveness to half‐occlusions in phantom stereograms
Authors: Kavšek Michael 
Published: August 2020

AbstractThe present natural preference study investigated infants 4 and 7 months of age for their ability to respond to phantom contoubrs, illusory surfaces generated by half‐occlusions in a stereoscopic display consisting of a pair of parallel vertical lines. The left line in the half‐image for the right eye and the right line in the half‐image for the left eye have a gap in the middle. The visual system accounts for the binocular unmatched gaps by perceiving an illusory contour. Infants in the experimental condition were presented with a standard phantom stereogram displaying a phantom contour versus a non‐standard phantom stereogram, the half‐images of which were exchanged. This stereogram evokes the impression of two small separate illusory contours. In both stereograms, the gaps moved up and down. The participants aged 7 but not 4 months preferred looking at the standard phantom stereogram. A control condition supported the hypothesis that the infants 7 months of age in the experimental condition indeed responded to the coherent illusory surface instead of simply detecting differences in the geometric arrangement of the half‐occlusions. The results hence indicate that infants are able to extract spatial information from monocular regions in a binocular display.
Standard Errors of Variance Components, Measurement Errors and Generalizability Coefficients for Crossed Designs
Authors: Almehrizi Rashid S. 
Published: August 2020

AbstractEstimates of various variance components, universe score variance, measurement error variances, and generalizability coefficients, like all statistics, are subject to sampling variability, particularly in small samples. Such variability is quantified traditionally through estimated standard errors and/or confidence intervals. The paper derived new standard errors for all estimated statistics for two crossed designs (single‐facet design and two‐facet design) in generalizability theory. The derivation was based on the assumption of multivariate normal distribution for observation scores using delta method. The derivation was differentiating between fixed and random facets. The adequacy of the derived standard errors was examined using Mont Carlo simulation for the two designs under several test conditions and compared to the traditional existing methods as well as implementation on real data. Results showed that the derived standard errors for all estimators are converging to the empirical standard errors for all simulation conditions with the two designs for both normal and non‐normal continuous data.
Pulmonary Artery Stenosis: Early Interventions With Low Profile Stents Versus Delayed Interventions With Large Diameter Stents
Authors: Pewowaruk Ryan , Pettit Kevin , Larrain Carolina , Johnson Cody , Francois Christopher J. , Lamers Luke , Roldán-Alzate Alejandro 
Published: August 2020

Abstract
Pulmonary artery stenosis (PAS) is a common complication of heart surgery in infancy. With recent advances in low profile-small diameter stent technology, PA stenting is now often performed in infants. While PAS stenting in older children does not impact distal PA growth and multiplication, in infants still undergoing significant PA growth, the impact of PA stent timing on long term PA development is unknown and potentially important. In a swine PAS model, the effects of early and delayed stent interventions on PA growth and cardiac function were comprehensively assessed. PA stenting had a positive impact on hemodynamics, lung perfusion, and histology, but the timing of intervention, either early or late, does not make a significant difference.
A Realistic Phantom for Ultrasound-Guided Central Venous Cannulation
Authors: Ng Si Yen , Lin Chi-Lun 
Published: August 2020

Abstract
Ultrasound-guided central venous cannulation (CVC) has become standard to care. Ultrasound imaging allows the CVC procedure to be completed much safer than a standard blind landmark approach. To enhance medical personnel’s skill in performing challenging ultrasound-guided CVC, an adult size CVC phantom that simulated the human head to the chest, with a detachable CVC operational part, was proposed in this study to provide medical personnel with realistic needle insertion haptic feedback and ultrasound imaging. The detachable CVC operational part could be customized to simulate different patient conditions, such as adult patient (with normal standard size of vascular), the elderly (with collapsed vascular), children (with smaller diameter of vascular), vascular fibrosis patient (with hardening of vascular) and obese patient (with thick fat tissue). In the current stage of prototype development, a CVC operational part with simulated blood vessels and clavicle embedded inside the fat- and muscle-mimicking tissue was produced. Both the fat- and muscle-mimicking tissue pose mechanical and acoustic properties similar to real tissues. The target vein for CVC procedure could be recognized from the ultrasound imaging of the CVC operational part.
Design of a Modular Cost-Effective Robot Arm for Increased Dexterity in Laparoscopic Surgery
Authors: Lowery John , Nelson Carl A. 
Published: August 2020

Abstract
This paper outlines the design of a reconfigurable, partially disposable, tendon-driven robotic arm for providing assistance in laparoscopic surgery. The rationale for its development and design objectives are provided, followed by a description of its mechanical design. Kinematic simulations to assess workspace are presented, and a first-stage assessment of the functionality of a prototype using a custom test bench is also included.
Development of a Pressure Measuring Garment to Understand How to Quantify Compression
Authors: Weber Michael , Clarke-Sather Abigail , Bergeron Tara , Janko Anisa , Jensen Alicia , Malvick Brittany , Cope Steven 
Published: August 2020

Abstract
Encouraging research shows reductions in the number of disruptive behaviors for children diagnosed with Autism Spectrum Disorder (ASD) when wearing compression shirts. However, current studies do not consider the amount of pressure compression shirts apply to the body and how different amounts of pressure applied to the body may lead to different outcomes for children diagnosed with ASD. The purpose of this proof of concept research project was to develop a method for measuring the pressure applied by a compression shirt at a specific location on the body. This study used conductive thread as the principle element to measure the compression applied by a garment onto the body, specifically the arm. It was found that for the specific stitch and thread tested, the relationship between the displacement the sensor exhibits and the change in resistance was 25.95 Ω/m. With this relation, the pressure applied by a compression garment to a mannequin arm and the arms of four participants was found. A general trend that the measured pressure applied by a garment onto the body directly correlated with increasing individual arm circumference was found.
Lung Allocation Pipeline: Machine Learning Approach to Optimized Lung Transplant
Authors: Schinstock Emma , Deakyne Alex , Iles Tinen , Shaffer Andrew , Iaizzo Paul A. 
Published: August 2020

Abstract
Lung donation is the most risky transplant procedures. With low survival rates, and poor acceptance of donated lungs, those in need of a lung transplant are at high risk of dying. One reason for poor outcomes is the lack of optimal match between donor and recipient when it comes to lung size and shape. Lungs that do not properly fit in the recipient’s chest cavity can fail to inflate fully and quickly start to deteriorate. In such patients, lung contusions can form, edema occurs in healthy lung tissue, and overall lung function declines. To improve patient outcomes after lung transplant, we describe here a developed a computational pipeline which enables donor lungs to be properly matched to recipients. This tool uses CT scans from both the donor and potential recipients to calculate how anatomically different the sets of lungs are, and therefore provide improved matches in both size and shape for the donor lungs.
Flexible Circuit Board Package Embedded With Multi-Stack Dies
Authors: Ueta Nobuki , Sato Shunsuke , Sato Masakazu , Nakao Yoshio , Magnuson Joshua , Ishizuka Rocky 
Published: August 2020

Abstract
Miniaturization of electronics modules is always required for various medical applications including wearable technology, such as hearing aids, and implantable devices. Many types of high-density packaging technologies, such as package-on-package, bare-die stack, flex folded package and Through Si Via (TSV) technologies, have been proposed and used to fulfill the request. Among them, embedded die technology is one of the promising technologies to realize miniaturization and high-density packaging. We have developed WABE™ (wafer and board level device embedded) technology for embedding dies into multilayer flexible printed circuit (FPC) boards. The WABE package is comprised of thin dies (85 μm thickness), multi-layer polyimide, adhesive films and conductive paste. The dies are sandwiched by polyimide films with Cu circuits (FPCs). The conductive paste provides electrical connections between the layers as well as the layer and embedded die. First, each FPC layer is fabricated individually, and via holes are filled with conductive paste, and the dies are mounted on certain layers. Then, all layers undergo a one-step co-lamination process, and they are pressed to cure the adhesive material and conductive paste at the same time. This WABE technology has enabled multiple dies to be embedded by the one-step lamination process. Even if multiple dies are embedded, the footprint of a package can be reduced drastically by embedding multiple dies vertically in stacks. This paper describes the details of the results of fabricating a test vehicle with six embedded dies (three-dies in two stacks side-by-side). The fabricated test vehicle had 14 copper layers with less than 0.9 mm thickness. This paper also reports the results of various reliability testing on the package. These results were obtained by electrical measurements of daisy chain patterns formed between some of the layers. The fabricated test vehicle showed high reliability based on the results of a moisture and heat test and heat-shock test. These results show that the WABE technology to embed multiple dies vertically in polyimide film is one of the most promising packaging technologies to significantly miniaturize electronic circuits such as medical electronics.
Novel Method and Device for Delivery and Retention of Intrauterine Devices in the Immediate Postpartum Period: Pilot Baboon Feasibility Study
Authors: Campbell Etse-Oghena , Rylander Christopher G. , Thaxton Lauren , Williams-Brown Marian Yvette 
Published: August 2020

Abstract
The immediate post-partum period offers a convenient time to have an intrauterine device placed because of the co-location of a non-pregnant woman and her clinician; however, this practice is associated with increased expulsion rates of up to 30%, compared with a 3% expulsion rate for interval insertions. This paper presents a device and method to improve intrauterine device delivery and retention in the immediate postpartum period. This initial feasibility study illustrates that it is possible to temporarily tether a commercially available intrauterine device within the uterus of an immediately postpartum baboon. The results indicate this device and method are technically feasible, but further studies will be needed to evaluate safety and efficacy in reducing expulsion rates.