bluuebunny/crossref_metadata_2025_split huggingface dataset:
UNDERSTANDING HADRAH ART AS THE LIVING AL-QUR’AN: THE ORIGIN, PERFORMANCE AND WORLDVIEW
Authors: Iswanto Agus 
Published: December 2019

<p><em>This article explores hadrah art in Lampung. Hadrah art actually becomes the most played religious music art among Indonesian Muslim in various areas. It focuses on the doctrinal basis of hadrah believed by Indonesian Muslim. By explaining the origin of the hadrah, its performances, tools and poems sung, with the living Qur’an concepts and interpretivism perspective, I found that hadrah is usually performed in religious rituals, then it is always contextual and connotative. Hadrah for Indonesian Muslim can be understood as the living Qur’an phenomenon because the underlying doctrine is shalawat from the Qur’an. As one of the phenomena of the living Qur’an, hadrah group, essentially, is reciting poems praising Allah and the Prophet of Muhammad, and they believe that it is as a command of the Qur’an. Thus, there has been acculturation between the teachings of the Qur’an with the local culture of society.</em></p><p><br /><em>Artikel ini membahas tentang seni hadrah di Lampung. Seni hadrah sebenarnya menjadi seni musik religius yang paling banyak dimainkan di kalangan Muslim Indonesia di berbagai wilayah. Artikel ini fokus pada dasar doktrinal hadrah yang diyakini oleh Muslim Indonesia. Dengan menjelaskan asal mula hadrah, pertunjukannya, alat-alatnya dan puisi-puisinya yang dinyanyikan, dengan menggunakan kerangka konsep Al-Qur’an yang hidup dan perspektif interpretivisme, terungkap bahwa hadrah biasanya dilakukan dalam ritual keagamaan, lalu selalu bersifat kontekstual dan konotatif. Hadrah bagi Muslim Indonesia dapat dipahami sebagai fenomena Al-Qur’an yang hidup, karena doktrin yang melandasinya adalah shalawat dari Al-Qur’an. Sebagai salah satu fenomena dari Al-Qur’an yang hidup, kelompok hadrah, pada dasarnya, melantunkan puisi yang memuji Allah dan Nabi Muhammad, dan mereka percaya bahwa itu adalah sebagai perintah Al-Qur’an. Dengan demikian, telah terjadi akulturasi antara ajaran Al-Qur’an dengan budaya masyarakat setempat.</em></p>
Islam Today in Modern West: Fazlur Rahman’s and Tariq Ramadan’s Views on Jihad
Authors: Chotimah Bimbo Chusnul 
Published: December 2019

This paper discusses the issues of radicalism that have reappeared in the public sphere nowadays. The discussion will focus on the interpretation of Jihad by Fazlur Rahman and Tariq Ramadan. They are among two modern reformers whose ideas heavily focus on the social, economic and political issues about Muslims in the West. This paper will discuss the thoughts of these two figures about jihad spread across their various writings. As a contemporary reformist Muslim leader, Rahman and Ramadan had made many interpretations of the Qur'an by adapting to the social context of society when the interpretation was made, namely Western society. Their Qur'anic interpretations and their thoughts-whether directly or indirectly-reflect on the circumstances and challenges that Muslims encounter in the West, Europe and the US, today. This paper contributes to the discussion of the meaning of jihad and various attempts at interpretation of the term. Besides, this paper will at least provide an overview of how the face of Islam in the West in the modern era as it is today.
Rethinking Jacques Derrida’s Deconstruction and its Relevance to the Study of Islam
Authors: Fattah Abdul 
Published: December 2019

This article examines Jacques Derrida’s concept of deconstruction and its implementation in the context of contemporary Islamic studies. Philosophically, the status of texts should not be regarded merely as writing because the meaning goes beyond the lexicogrammatical boundaries. Hence, scrutinizing ways to unveil hidden meanings possibly entail subjective or partial values embedded in the texts, particularly religious texts pertinent to Islamic civilization (turāth). Based on the philosophical analysis of the Derrida’s work, this study shows that there are at least two points of the relevance of the Derrida's philosophical thought to deconstruct the turāth and the Western domination in Muslim society. First, it is a useful device to criticise and deconstruct religious thoughts and texts, which are, to some extent, still dominant and considered sacred. These cover a wide range of Islamic texts that build Islamic civilization, from mysticism, law to theology. The second dimension is dismantling the context (today Muslim civilization) through decentralization of the Western hegemony and promotion of Occidentalism, a way of seeing the West from the East.
Low Bone Mineral Density Could Predict Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
Authors: Lee Sang-Hwa , Jang Min Uk , Kim Yerim , Park So Young , Kim Chulho , Kim Yeo Jin , Sohn Jong-Hee 
Published: December 2019

Abstract
Background Little is known about the effect of osteoporosis at the acute and recovery phase of stroke on cognitive function. We evaluated the effect of osteoporosis on cognitive function in patients with ischemic stroke aged >50 years. Methods We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T score of <-2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. The association between osteoporosis and the severity of cognitive impairment was investigated using a multivariate analysis. Results Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p=0.001). After recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio [OR] 3.66, 95% confidence interval [CI] 1.05-12.79 in the acute phase and adjusted OR 11.17, 95% CI 1.12-110.98 in the recovery phase), whereas lumbar spine osteoporosis was not associated with cognitive impairment. Conclusions Low bone mineral density is associated with poor cognitive function in patients with acute stroke. Early bone mineral density assessments during acute stroke, particularly at the femoral neck, may be a useful marker of cognitive function.
TNFAIP3 in circulating and parenchymal myeloid lineage critically controls monocytes, monocytes-derived cells and microglia
Authors: Montarolo Francesca , Perga Simona , Tessarolo Carlotta , Spadaro Michela , Martire Serena , Bertolotto Antonio 
Published: December 2019

Abstract
Background. The intracellular ubiquitin-ending enzyme TNFAIP3 is one of the most potent inhibitor of the pro-inflammatory NF-kB pathway. Single nucleotide polymorphisms in the TNFAIP3 locus have been associated to autoimmune inflammatory disorders, including Multiple Sclerosis (MS). Previously, we reported a TNFAIP3 down-regulated gene expression level in blood and specifically in CD14+ monocytes obtained from treatment naïve MS patients in comparison to healthy controls (HC). Notably, myeloid cells which include monocytes, exert a key role in the neuro-inflammatory pathogenic process of MS.Methods. Here, we evaluated the effect of the specific TNFAIP3 deficiency in myeloid cells including monocytes, monocyte-derived cells (M-MDC) and microglia analyzing the lymphoid organs and central nervous system (CNS) of experimental mice. The TNFAIP3 deletion is induced using conditional knock-out mice for the myeloid lineage. Flow cytometry and histological procedures were applied to evaluate the immune cell population of spleen, lymph nodes and bone marrow and the microglial cell density in CNS, respectively.Results. Here, we found that the deletion of TNFAIP3 in myeloid cells induces a reduced body weight, a decrease in the percentage number of M-MDC and of common monocyte and granulocyte precursor cells. We also reported that the deletion of TNFAIP3 in myeloid cells reports an increased microglial cell density in brain.Conclusions. Collectively, the results suggest that the presence of TNFAIP3 in myeloid cells critically controls the development of M-MDC in lymphoid organ and of microglia in brain.
Effect of Annickia polycarpa (Stten and Mass.) Annonaceae, leaf extract on chemo-suppression of hyperparasitemia, body weight, hematological indices and survivor time of Plasmodium berghei infested mice in the Peter’s test
Authors: Ayertey Frederick , Kumatia Emmanuel Kofi , Bagyour Godfrey Kyaakyile , Asare Kenneth Opare , Mbatchou Valantine Chi , Dabo Jonathan 
Published: December 2019

Abstract
Background: Malaria is an infectious disease that is spread through the bite of female anopheles mosquito resulting in the death of hundreds of thousands of people per year. Medicinal plants provide crude extracts and purified compounds for malaria treatment. Annickia polycarpa is one of such plants whose bark is used for this purpose. However, the antimalaria effect of its leaf is not known. We hereby report the investigation of antimalaria effect of A. polycarpa leaf. Methods: Antimalaria effect of the ethanol extract of A. polycarpa leaf (APLE) was investigated in P. berghei infested ICR mice in the Peter’s test. The effect of the extract on development and chemo-suppression of hyperparasitemia, reduction in body weight and mean survival time were evaluated. Full blood count analysis on the infected mice were performed to determine the effect of treatment with APLE on hematological indices such as red and white blood cells and platelets. Acute toxicity and phytochemical tests of the extract were also performed. Results: APLE administered orally at 50, 200 and 400 mg/kg produced profound dose-dependent chemo-suppressive effect of 89.37 – 95.50 % of P. berghei after 4 consecutive days of treatment which compares with 86.22 % obtained for Quinine 30 mg/kg i.m. under the same regimen. APLE also protected the mice against reduction in body weight associated with malaria which was P < 0.05 at 50 mg/kg. Furthermore, APLE promoted dose-dependent mean survival time in the Kaplan-Meier curve. Only 25.0 % of mice in the negative control group survived after 30 days compared to 100 % survival for mice in APLE 400 mg/kg and Quinine 30 mg/kg groups. The results from the full blood count shows that APLE caused (P < 0.05) dose dependent increase in RBC, HGB, HCT, WBCs, lymphocytes and platelets. The LD50 of APLE was above 5000 mg/kg p.o. Conclusions: APLE showed profound antimalaria effect with very high margin of safety. Hematological alterations that resulted from treatment of with APLE indicate significant improvement in general health and safe recovery from the parasitic attack. These findings show that the leaf of A. polycarpa can also be used to treat malaria.
Identifying the Biomarkers of Spinal Cord Injury and the effects of Neurotrophin-3 Based on MicroRNA and mRNA Signature
Authors: Qi Shuang , Li Zinan , Yu Shanshan 
Published: December 2019

Abstract
Background: To gain a better understanding of the molecular mechanisms of spinal cord injury and the effects of Neurotrophin-3, differentially expressed microRNAs (DEmiRNAs) and genes (DEGs) were analyzed. Methods: The miRNA transcription profile of GSE82195 and the mRNA transcription profile of GSE82196 including dorsal root ganglion (DRG) tissue samples of normal adult rat (none, n=6), 10 weeks post-pyramidotomy, intramuscular AAV-1 GFP (injury, n=6) and 10 weeks post-pyramidotomy, intramuscular AAV-1 prepro-neurotrophin-3 (NT-3, n=6) were downloaded from the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/). Then, differentially expressed RNAs (DERs) including DEmiRNAs and DEGs were identified using limma. The noise-robust soft clustering of the intersection DERs was performed using Mfuzz package. Additionally, the integrated miRNAs–targets regulatory network was constructed using Cytoscape. Finally, the Comparative Toxicogenomics Database 2019 update (http://ctd.mdibl.org/) were used to search the central nervous system injury related pathway. Results: A total of 444 DERs including 382 DEGs and 62 DEmiRNAs were screened between group injury and group none whlie 576 DERs including 523 DEGs and 55 DEmiRNAs were screened between group NT-3 and group injury. Moreover, 80 intersections DERs were identified.Two clusters were obtained including cluster 1 (including rno-miR-3072, rno-miR-667-5p and so on) and cluster 2 (OPRL1, GHSR and so on). DREs in cluster 1 were firstly significantly downregulated in group injury and subsequently were significantly upregulated in group NT-3. DERs in cluster 2 were firstly upregulated in group injury and subsequently downregulated in group NT-3. OPRL1 and GHSR were enriched in the KEGG pathway of Neuroactive ligand-receptor interaction which is also found in the Comparative Toxicogenomics Database 2019 update. OPRL1 was involved in the chemical homeostasis and ion homeostasis while GHSR was related to the regulation of fatty acid metabolic process and regulation of cellular ketone metabolic process. Conclusion: DEmiRNAs rno-miR-3072 and rno-miR-667-5p and DEGs OPRL1 and GHSR might participate in the pathogenesis of neurological injury and the neurotrophin-3 treatment. Keywords: spinal cord injury, differentially expressed miRNA, differentially expressed gene, regulatory network, Neurotrophin-3
Nicotinamide inhibits Heterotopic ossification decreasing Smad 1/5/8 phosphorylation
Authors: Quevedo Ivan , Rivas-Valdes Fernando , Gutierrez Soraya 
Published: December 2019

Abstract
Heterotopic ossification (HO) is a condition in wich extra-skeletal bone formation occurs in soft tissues of the body. HO is formed in numerous clinical situations such as burns, neurological damage, post-combat trauma, hip surgery, etc. The most severe condition of heterotopic ossification is the pathology called Fibrodysplasia Ossificans Progressiva (FOP), wich is produced by a point mutation in the ACVR1 receptor gene, triggering its constitutive activation and a hyper-activation of the SMAD pathway. Different pharmacological treatments have been used to inhibit the progression of ossification outbreaks, but a low effectiveness has been reported. An alternative therapy is the use of nicotinamide where a delay in the appearance of ossification flare ups has been observed.
However, its effect on the SMAD-mediated signaling pathway is not known. In this work we use nicotinamide in culture of C2C12 cells in the presence or absence of the osteoinductive BMP-2 to investigate its effect on osteoblastogenesis. Through western blot, Inmmunocytochemistry and Real time PCR we investigated the effect of nicotinamide on the SMAD pathway and gene expression of genes involved in the pathology. Our results show that in the presence of nicotinamide a decrease in the osteoblast differentiation and in SMAD complex phosphorylation levels while expression of the ACVR1 BMP-2 receptor and Runx2 are not affected by the treatment. New evidence is provided regarding the mechanism by which nicotinamide acts. These findings could be helpful in the clinic for the treatment of diseases related to HO bone formation.
Effects of maternal smoking during pregnancy on congenital anomalies: Results from the Japan Environment and Children's Study (JECS)
Authors: Tsuchida Akiko , Hamazaki Kei , Kigawa Mika , Tanaka Tomomi , Ito Mika , Inadera Hidekuni 
Published: December 2019

Abstract
Objective
Tobacco smoke contains over 7,000 chemical compounds, tobacco smoking is a possible risk factor of congenital anomalies (CAs). Therefore, we investigated the relationship between maternal smoking during pregnancy and CAs in children. Drawing data from the Japan Environment and Children’s Study (JECS), gathered between January 2011 and March 2014, 91,626 pregnant Japanese women were included.

Results
Of 91,626 subjects examined, 2.4% (2,183) of their infants had “any CAs.” By smoking behavior; 1,256 (57.5%), 523 (23.9%), 271 (12.4%), and 136 (6.2%) subjects were in the “never smoked,” “quit before pregnancy,” “quit after pregnancy,” and “still smoking” groups, respectively. The odds ratios (OR) for any CAs were not significant when “quit before pregnancy,” or “quit after pregnancy,” groups were compared to the “never smoked” group. However, upon comparing “never smoked” group with the “still smoking” group regarding “any CAs,” the OR was significant (OR 1.38, 95% confidence interval, 1.13-1.69, p=0.002). This study showed association between smoking continuation during pregnancy and an increased risk of CAs. This study results may be used as the basis for recommending anti-smoking education for pregnant women, and younger yet-to-become pregnant women.
Examining Teachers’ Perceived Barriers to the Integration of Critical Thinking in Moroccan High Schools
Authors: Laabidi Youssouf 
Published: December 2019

<em><span lang="EN-CA">Several scholars acknowledge that the ability to think critically and process new information is a skill that must be learnt in order to challenge a rapidly changing world. It is important to enhance students’ critical thinking skills to help them be successful in their upcoming life plans in numerous domains. In other words, integrating critical thinking skills in schools is not only a way to assist learners obtain favorable outcome in schools, but it is also crucial if learners are going to be able to operate in an increasingly difficult world. However ; little attention has been given to examine strategies that can help teachers incorporate critical thinking skills in education. This paper attempts to address the importance of critical thinking in education. Besides, it aims to discuss the issue of teaching critical thinking for the 21st century students learning English as a foreign language. Finally, the paper addresses elements that prevent the improvement of critical thinking in classrooms.</span></em>
Citrullination Site Prediction by Incorporating Sequence Coupled Effects into PseAAC and Resolving Data Imbalance Issue
Authors: Hasan Md. Al Mehedi , Ben Islam Md Khaled , Rahman Julia , Ahmad Shamim 
Published: December 2019

Background:
Post-translational modification is one of the bio-molecular mechanisms in
living organisms, which incorporate functional diversity in proteins as well as regulate cellular
processes. Transformation of arginine residue to citrulline in protein is such a modification.

Objective:
Our objective is to identify citrullinated arginine residue sites quickly and accurately.

Methods:
In this study, a novel computational tool, abbreviated as predCitru-Site, has been
developed to predict citrullination sites. This technique effectively has incorporated the sequencecoupling
effect of surrounding amino acids of arginine residues as well as optimizes skewed
training citrullination dataset for prediction quality improvement. The performance of predCitru-
Site has been measured from the average of 5 complete runs of the 10-fold cross-validation test to
comply with existing tools.

Results and Conclusion:
predCitru-Site has achieved 97.6% sensitivity, 98.9% specificity, and
overall accuracy of 98.5%. With Matthew’s correlation coefficient of 0.967, it has also shown an
area under the receiver operator characteristics curve of 0.997. Compared with existing tools,
predCitru-Site significantly outperforms on the same benchmark dataset. It also shows significant
improvement in the case of independent tests in all performance metrics (around 50% higher in
AUC). These results suggest that our method is promising and can be used as a complementary
technique for fast exploration of citrullination in arginine residue. A user-friendly web server has
also been deployed at http://research.ru.ac.bd/predCitru-Site/ for the convenience of experimental
scientists.
Efektifitas modifikasi permainan tradisional dalam pengembangan physical literacy anak taman kanak-kanak
Authors: Gustian Uray , Supriatna Eka , Purnomo Edi 
Published: December 2019

Perkembangan gerak merupakan aspek penting dalam lingkup perkembangan anak. Akan tetapi, seiring dengan perubahan pola hidup dan pengaruh gadget yang menyebabkan anak menjadi kurang dalam melakukan gerak. Untuk itu diperlukan suatu usaha untuk menstimulus anak selalu aktif, memiliki keterampilan, pengetahuan, motivasi dan kepercayaan diri melakukan aktivitas gerak (Physical literacy) yang dilakukan sejak taman kanak-kanak. Penelitian menggunakan metode eksperimen dengan mengimplementasikan permainan tradisional yang dimodifikasi pada pembelajaran anak taman kanak-kanak dan partisipan berjumlah 150 anak. Permainan tradisional yang digunakan dalam pembelajaran terdiri atas tujuh permainan tradisional yaitu permainan lempar kaleng, permainan engklek, permainan lempar telur penyu, sumpitan, balap balon, estafet kelereng, dan bakiak. Penilaian dilakukan dengan teknik unjuk kerja menggunakan rubrik penelitian. Hasil penelitian secara keseluruhan diperoleh nilai 10843 (3.02) pada pertemuan I dan 11596 (3.22) pada pertemuan I dan telah terjadi peningkatan sebesar 753 point (0.21). Peningkatan ini terjadi disebabkan permainan tradisional menstimulus anak selalu aktif melakukan aktivitas gerak melalui bermain. Hal ini menunjukan permainan tradisional efektif dalam mengembangan physical literacy anak taman kanak-kanak. Effectiveness of traditional game modified to develop a physical literacy in preschool student AbstractMotor development is an important aspect in the scope of the child's development. However, along with changes in lifestyle and the influence of gadgets that caused children to be less in motion. For this reason, an effort is needed to stimulate children to always be active, have the skills, knowledge, motivation and self-confidence to carry out physical literacy carried out since preschool. The study was used the experimental method by implementing a modified traditional game on kindergarten learning and 150 participants. The traditional games used in learning consist of seven traditional games namely can throwing games, crunch games, turtle egg throwing games, blowpipes, balloon racing, marbles relay and clogs. Assessment is done by performance techniques using the research rubric. The overall results of the study obtained values of 10843 (3.02) at meetings I and 11596 (3.22) at meeting I and there had been an increase of 753 points (0.21). this increase occurs because traditional games stimulate children to always actively engage in motion activities through play. This shows that traditional games are effective in developing physical literacy of preschool student.
Burocratas de Médio Escalão: novos olhares sobre velhos atores da produção de políticas públicas
Authors: Lotta Gabriela Spanghero , Pires Roberto Rocha C. , Oliveira Vanessa Elias 
Published: December 2019

O artigo tem como objetivo apresentar os resultados de uma revisão da literatura nacional e internacional sobre burocratas de médio escalão (BMEs). A sistematização da literatura se orientou a partir de uma perspectiva de políticas públicas, voltada para a compreensão da existência e atuação desses atores e das suas influências sobre os processos de produção de políticas públicas e ações governamentais. Três dimensões da atuação da burocracia de médio escalão foram analisadas: seus papeis, funções e “lugares”; as perspectivas analíticas a partir das quais são observados (estrutural, individual e relacional); e, por fim, a sua atuação nas políticas públicas setoriais. Dois aspectos merecem destaque a partir da revisão bibliográfica empreendida. Em primeiro lugar, o fato de que os BMEs merecem maior atenção nas análises dos processos de produção de políticas públicas. Somado a isso, explicita-se as ausências existentes na literatura nacional no que tange a relevância e centralidade desse ator. Palavras-chave: burocracia, administração pública, políticas públicas, agente público