bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential influencing factors on the outcome in incisional hernia repair: a registry-based multivariable analysis of 22,895 patients
Authors: Köckerling F. , Hoffmann H. , Adolf D. , Reinpold W. , Kirchhoff P. , Mayer F. , Weyhe D. , Lammers B. , Emmanuel K. 
Published: April 2020

Abstract
Introduction
Due to the paucity of randomized controlled trials, meta-analyses of incisional hernia repair can hardly give any insights into the influence factors on the various outcome criteria. Therefore, a multivariable analysis of data from the Herniamed Registry was undertaken with the aim to define potential influencing factors for the outcome.

Methods
Multivariable analysis of the data available for 22,895 patients with primary elective incisional hernia repair was performed to assess the confirmatory predefined potential influence factors and their association with the perioperative and 1-year follow-up outcomes. A model validation procedure was implemented using a bootstrap algorithm in order to account for the robustness of results.

Results
Higher European Hernia Society (EHS) width classification, open procedure, female gender, and preoperative pain have a highly significant association with an unfavorable outcome in incisional hernia repair. Larger defect width and open operation have a highly significantly unfavorable relation to the postoperative surgical complications, general complications, and the complication-related reoperations, while female gender and preoperative pain have a highly significantly unfavorable association with the rates of pain at rest, pain on exertion, and chronic pain requiring treatment at 1-year follow-up. The recurrence rate is significantly unfavorably influenced by higher EHS width classification, higher BMI, and lateral EHS classification.

Conclusion
Higher EHS width classification, open procedure, female gender, higher BMI, and lateral EHS classification, as well as preoperative pain are the most important unfavorable influencing factors associated with a worse outcome in incisional hernia repair.
Comparison of HIV Risk Behaviors Between Clinical Trials and Observational Cohorts in Uganda
Authors: Abaasa Andrew , Nash Stephen , Mayanja Yunia , Price Matt A. , Fast Patricia E. , Kaleebu Pontiano , Todd Jim 
Published: April 2020

AbstractMany key populations have high-risk behaviors for HIV infection making them suitable for HIV vaccine efficacy trials. However, these behaviors may change when participants enroll into a trial. We used HIV simulated vaccine efficacy trials (SiVETs) nested within observational cohorts of fisherfolks and female sex workers in Uganda to evaluate this difference. We screened observational cohort participants for enrolment into SiVETs, until 572 were enrolled. Those not enrolled (n = 953) continued participation in the observational cohorts. We determined risk behaviors at baseline and at 1 year, assigned a numeric score to each behavior and defined composite score as the sum of reported behaviors. We compared changes in scores over 12 months. Both observational cohorts and SiVETs saw a significant decrease in score but greatest in the SiVETs. Investigators recruiting for trials from these populations should consider the likely effect of reduction in risk behaviors on incident HIV infection and trial statistical power.
Effect of SAMe-TT2R2 score and genetic polymorphism on the quality of anticoagulation control in Qatari patients treated with warfarin
Authors: Elewa Hazem , Qurishi Iqrah , Abouelhassan Rawan , Abou Safrah Salam , Alhamoud Eman , Bader Loulia 
Published: April 2020

AbstractThere is no strong evidence on pharmacogenetics role on the quality of INR control after the initiation phase and on the maintenance of stable INR on the long term as measured by the time in therapeutic range (TTR). The benefit of a score such as SAMe-TT2R2 is that it can preemptively guide clinicians on whether to start the patient on warfarin or direct oral anticoagulant. To determine the association between genetic variants in CYP2C9, VKORC1, and CYP4F2 and TTR. To validate SAMe-TT2R2 score predictive ability on the quality of anticoagulation in Qatari patients. This is an observational nested case–control study that was conducted on a cohort of Qatari patients treated with warfarin with previously identified genotype for the CYP2C9, VKORC1, and CYP2F4. The sample size of this cohort was 148 patients. Mean TTR was 62.7 ± 21%. TTR was not significantly different among carriers of the CYP2C9*2 &*3, VKORC1(–1639G>A) or CYP4F2*3 compared to their non-carriers alleles. None of the factors in the SAMe-TT2R2 score had a significant effect on the TTR except for the female gender where TTR was significantly lower in females (n = 89) compared to males (n = 59) (59.6 ± 21% vs. 67.2 ± 20%, p = 0.03). Furthermore, patients with SAMe-TT2R2 score of zero had significantly better TTR compared to those with higher scores (76.5 ± 17% vs. 61.8 ± 21%, p = 0.04). Logistic regression analysis showed that high SAMe-TT2R2 score was the only statistically significant predicting factor of poor INR control (odds ratio (OR) 5.7, 95% confidence interval (CI) 1.1–28.3, p = 0.034). Genetic variants have no contribution to the quality of INR control. SAMe-TT2R2 score was predictive for the poor quality of anticoagulation in a cohort of Qatari patients.
Correction to: Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice
Authors: Ishii Toshinari , Okuyama Tetsuya , Noguchi Nao , Nishidono Yuto , Okumura Tadayoshi , Kaibori Masaki , Tanaka Ken , Terabayashi Susumu , Ikeya Yukinobu , Nishizawa Mikio 
Published: April 2020

The article Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice, written by Toshinari Ishii, Tetsuya Okuyama, Nao Noguchi, Yuto Nishidono, Tadayoshi Okumura, Masaki Kaibori, Ken Tanaka, Susumu Terabayashi, Yukinobu Ikeya and Mikio Nishizawa was originally published Online First without Open Access. After publication in volume 74 issue 1, page 51–64 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
The Area Preserving Willmore Flow and Local Maximizers of the Hawking Mass in Asymptotically Schwarzschild Manifolds
Authors: Koerber Thomas 
Published: April 2020

AbstractWe study the area preserving Willmore flow in an asymptotic region of an asymptotically flat manifold which is$$C^3$$C3-close to Schwarzschild. It was shown by Lamm, Metzger and Schulze that such a region is foliated by spheres of Willmore type, see (Lamm et al. in Math Ann 350(1):1–78, 2011). In this paper, we prove that the leaves of this foliation are stable under small area preserving$$W^{2,2}$$W2,2-perturbations with respect to the area preserving Willmore flow. This implies, in particular, that the leaves are strict local area preserving maximizers of the Hawking mass with respect to the$$W^{2,2}$$W2,2-topology.
Irlactane and Tremulane Sesquiterpenes from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102
Authors: Chen He-Ping , Ji Xu , Li Zheng-Hui , Feng Tao , Liu Ji-Kai 
Published: April 2020

AbstractA new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A–N (2–15), and a known irlactane-type sesquiterpenoid, were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102. The structures of all the isolates were characterized by extensive spectroscopic methods, including 1D and 2D NMR and MS spectroscopic analysis. The absolute configurations of irlactin K and the known compound conocenol B (20) were established by single-crystal X-ray diffraction analysis. The vasorelaxant effects of irlactin K (1), irpexolactins A (2), C (4), K (12), and irlactam (22) were evaluated.
Graphic Abstract
QSAR modeling, molecular docking and ADMET/pharmacokinetic studies: a chemometrics approach to search for novel inhibitors of norepinephrine transporter as potent antipsychotic drugs
Authors: Olasupo Sabitu Babatunde , Uzairu Adamu , Shallangwa Gideon , Uba Sani 
Published: April 2020

AbstractChemometrics study that relates biological activity to physicochemical descriptors of a molecule and the prediction of absorption, distribution, metabolism, excretion and toxicity (ADMET) properties in advance are important steps in drugs discovery. In this study, a chemometrics approach was employed on some molecules (inhibitors) of norepinephrine transporter to assess their inhibitory potencies, interactions with the receptor and predict their ADMET/pharmacokinetic properties for identification of novel antipsychotic drugs. The molecules were optimized by using density functional theory at the basis set of B3LYP/6-31G*. The genetic function algorithm technique was used to generate a statistically significant model with a good correlation coefficient R2Train = 0.952 Cross-validated coefficient Q2cv = 0.870, and adjusted squared correlation coefficient R2adj = 0.898. The molecular docking simulation using a neurotransmitter transporter receptor (PDB Code 2A65) revealed that three inhibitors (molecule No 38, 44 and 12) exhibited the highest binding affinity of − 10.3, − 9.9 and − 9.3 kcal/mol, respectively, were observed to inhibit the target by forming strong hydrogen bonds with hydrophobic interactions. The physicochemical and ADMET/pharmacokinetic properties result showed that these three molecules are orally bioavailable, high gastrointestinal absorption, good permeability and non-inhibitors of CYP3A4 and CYP2D6 except for molecule No 38. Also, Molecules No 38 and 44 proved to be non-substrate of P-glycoprotein and nontoxicity to a human ether-a-go-go-related gene with predicted hERG toxicity endpoints (pIC50 < 6) and low ADMET_Risk (< 7.0). The results of this study would provide physicochemical and pharmacokinetics properties needed to identify potent antipsychotic drugs and other relevant information in drug discovery.
Recent developments in methane decomposition over heterogeneous catalysts: an overview
Authors: Hasnan Nur Shamimie Nadzwin , Timmiati Sharifah Najiha , Lim Kean Long , Yaakob Zahira , Kamaruddin Nur Hidayatul Nazirah , Teh Lee Peng 
Published: April 2020

AbstractThe production of hydrogen to be used as an alternative renewable energy has been widely explored. Among various methods for producing hydrogen from hydrocarbons, methane decomposition is suitable for generating hydrogen with zero greenhouse gas emissions. The use of high temperatures as a result of strong carbon and hydrogen (C–H) bonds may be reduced by utilizing a suitable catalyst with appropriate catalyst support. Catalysts based on transition metals are preferable in terms of their activeness, handling, and low cost in comparison with noble metals. Further development of catalysts in methane decomposition has been investigated. In this review, the recent progress on methane decomposition in terms of catalytic materials, preparation method, the physicochemical properties of the catalysts and their performance in methane decomposition were presented. The formation of carbon as part of the reaction was also discussed.Graphic abstract
Integrated care for the management of ageing-related non-communicable diseases: current gaps and future directions
Authors: Monaco Alessandro , Palmer Katie , Marengoni Alessandra , Maggi Stefania , Hassan Tarek A. , Donde Shaantanu 
Published: April 2020

AbstractDue to the increase in the older population in Europe and associated rise in the absolute number of persons with Non-Communicable Diseases (NCDs), it is becoming increasingly important to find ways to promote healthy ageing, which is defined as the process of developing and maintaining the functional ability that enables well-being in older age. Older persons with NCDs can have complex care needs due to the increased risk of frailty, multimorbidity, and polypharmacy. However, current health systems in Europe often provide fragmented care for older people with NCDs; many receive disjointed care from numerous specialists or via different levels of care. In the current article, we discuss barriers and challenges in implementing integrated care models in European settings for older NCD patients. Specifically, we discuss the need for greater use of case managers in the care and treatment persons with complex care needs as well as the lack of training and education in healthcare professionals on topics related to multimorbidity, frailty, and polypharmacy. We discuss the limitations that arise from the current focus on disease-specific guidelines and care models that do not take comorbid conditions into account, and the lack of good quality evidence that evaluates the effectiveness of integrated care interventions, especially in European health settings. We highlight the importance of evaluating and monitoring mental health in conjunction with somatic symptoms in NCD patients and discuss the integral role of information and communication technology in healthcare to streamline integrated care processes and help to achieve better outcomes for patients.
Interseismic Loading of Subduction Megathrust Drives Long‐Term Uplift in Northern Chile
Authors: Jolivet R. , Simons M. , Duputel Z. , Olive J.‐A. , Bhat H. S. , Bletery Q. 
Published: April 2020

AbstractLarge earthquakes are the product of elastic stress that has accumulated over decades to centuries along segments of active faults. Assuming an elastic crust, one can roughly estimate the location and rate of accumulation of elastic stress. However, this general framework does not account for inelastic, irrecoverable deformation, which results in large‐scale topography. We do not know over which part of the earthquake cycle such deformation occurs. Using InSAR and GNSS measurements, we report on a potential correlation between long‐term, inelastic vertical rate and short‐term, interseismic vertical rate in northern Chile. Approximately 4% to 8% of the geodetically derived interseismic vertical rates translate into permanent deformation, suggesting that topography of the forearc builds up during the interseismic period. This observation provides a quantitative basis for an improved understanding of the interplay between short‐term and long‐term dynamics along convergent plate boundaries.
Flux Erosion of Magnetic Clouds by Reconnection With the Sun's Open Flux
Authors: Pal Sanchita , Dash Soumyaranjan , Nandy Dibyendu 
Published: April 2020

AbstractMagnetic clouds (MCs) are flux rope magnetic structures forming a subset of solar coronal mass ejections, which have significant space weather impacts. The geoeffectiveness of MCs depends on their properties, which evolve during their interplanetary passage. Based on an analysis of observations spanning two solar cycles, we establish that MCs interacting with the ambient solar wind magnetic field (i.e., heliospheric open flux) lose a substantial amount of their initial magnetic flux via magnetic reconnection, which, in some cases, reduce their geoeffectiveness. We find a linear correlation between the eroded flux of MCs and solar open flux which is consistent with the scenario that MC erosion is mediated via the local heliospheric magnetic field draping around an MC during its interplanetary propagation. The solar open flux is governed by the sunspot cycle. This work therefore uncovers a hitherto unknown pathway for solar cycle modulation of the properties of MCs.
Fluid Surface Coverage Showing the Controls of Rock Mineralogy on the Wetting State
Authors: Garfi Gaetano , John Cédric M. , Lin Qingyang , Berg Steffen , Krevor Samuel 
Published: April 2020

AbstractThe wetting state is an important control on flow in subsurface multi‐fluid phase systems, for example, carbon storage and oil production. Advances in X‐ray imaging allow us to characterize the wetting state using imagery of fluid arrangement within the pores of rocks. We derived a model from equilibrium thermodynamics relating fluid coverage of rock surfaces to wettability and fluid saturation. The model reproduces the behavior measured in a water‐wet, nearly all‐quartz, Bentheimer sandstone imaged during steady‐state imbibition. A shift in fluid surface coverage is observed when the rock is altered to a new wetting state with crude oil. In two multimineralogical (Berea) samples, one water‐wet and the other altered with crude oil, the analysis of fluid surface coverage after imbibition revealed mineral specific wetting preferences only in the altered system. Clays and calcite preferentially alter to an oil‐wet state, leading to mixed wettability in the rock.
Calving Seasonality Associated With Melt‐Undercutting and Lake Ice Cover
Authors: Mallalieu Joseph , Carrivick Jonathan L. , Quincey Duncan J. , Smith Mark W. 
Published: April 2020

AbstractA detailed understanding of calving processes at the lacustrine margins of the Greenland ice sheet is necessary for accurately forecasting its dynamic response to ongoing climate change. However, existing data sets of lacustrine calving are limited to summer seasons and to alpine glaciers. Here, we use an integrated time‐lapse and structure‐from‐motion approach to generate the first continuous year‐round volumetric record of calving processes at a lacustrine ice sheet margin. We identify two distinct calving regimes that are associated with melt‐undercutting and lake ice cover. We also find that calving rates respond rapidly to sudden lake drainage. Given that lake temperature, lake ice cover, and sudden lake drainages are controlled by air temperature and ice‐margin thinning, we suggest that climate change, manifested in lengthening summer seasons, will accelerate rates of mass loss and terminus recession at lacustrine ice‐margins in Greenland.
Uncertainties in Future U.S. Extreme Precipitation From Downscaled Climate Projections
Authors: Lopez‐Cantu Tania , Prein Andreas F. , Samaras Constantine 
Published: April 2020

AbstractImpacts modelers and stakeholders use publicly available data sets of downscaled climate projections to assess and design infrastructure for changes in future rainfall extremes. If differences across data sets exist, infrastructure resilience decisions could change depending on which single data set is used. We assess changes in U.S. rainfall extremes from 2044–2099 compared with 1951–2005 based on 227 projections under RCP4.5 and RCP8.5 from five widely used data sets. We show there are large differences in the change magnitude and its spatial structure between data sets. At the continental scale, the data sets show different increases, with high‐end extremes (e.g. 100‐year event) generally increasing more (between 10% and 50%) than low‐end extremes (e.g. 5‐year). These differences largely contribute to the overall uncertainty for small average recurrence intervals (ARIs) extremes (2‐ to 10‐year), while uncertainties due to short record length dominate large ARIs (25‐ to 100‐year). The results indicate that robust infrastructure planning should consider these uncertainties to enable resilient infrastructure under climate change.
Global Wave Height Trends and Variability from New Multimission Satellite Altimeter Products, Reanalyses, and Wave Buoys
Authors: Timmermans B. W. , Gommenginger C. P. , Dodet G. , Bidlot J.‐R. 
Published: April 2020

AbstractLong‐term changes in ocean surface waves are relevant to society and climate research. Significant wave height climatologies and trends over 1992–2017 are intercompared in four recent high‐quality global datasets using a consistent methodology. For two products based on satellite altimetry, including one from the European Space Agency Climate Change Initiative for Sea State, regional differences in mean climatology are linked to low and high sea states. Trends from the altimetry products, and two reanalysis and hindcast datasets, show general similarity in spatial variation and magnitude but with major differences in equatorial regions and the Indian Ocean. Discrepancies between altimetry products likely arise from differences in calibration and quality control. However, multidecadal observations at two buoy stations also highlight issues with wave buoy data, raising questions about their unqualified use, and more fundamentally about uncertainty in all products.
The Effects of Viewing Geometry on the Spectral Analysis of Lunar Regolith as Inferred by in situ Spectrophotometric Measurements of Chang'E‐4
Authors: Yang Yazhou , Lin Honglei , Liu Yang , Lin Yangting , Wei Yong , Hu Sen , Yang Wei , Xu Rui , He Zhiping , Zou Yongliao 
Published: April 2020

AbstractThe visible and near‐infrared imaging spectrometer on board the Yutu‐2 rover of Chang'E‐4 mission has conducted 2 sets of spectrophotometric measurements at two sites on its 10th lunar day. At each site, the reflectance spectra were measured on the same lunar regolith at different geometric configurations. The experiments reveal an increasing trend of the spectral reddening effect with the increasing phase angles, which may cause significant uncertainties on interpreting the maturity of the lunar regolith. Furthermore, the phase angles have significant effects on the 2‐μm band center and the 1‐μm band depth of the spectra, consequently on the estimation of mineral composition of the regolith. Finally, the derived average Hapke parameters using the in situ spectrophotometric measurements provide important ground‐truth for remote sensing observations.
Modulation of Pc1 Wave Ducting by Equatorial Plasma Bubble
Authors: Kim Hyangpyo , Shiokawa Kazuo , Park Jaeheung , Miyoshi Yoshizumi , Hwang Junga , Kadokura Akira 
Published: April 2020

AbstractDucting Pc1 waves are observed over a wide latitudinal range by the low‐Earth orbit satellites as compressional mode. In this paper, we present the first observation of the modulation of ducting Pc1 waves by equatorial plasma bubbles (EPBs) based on the Swarm satellites. We show two ducting Pc1 events propagating across EPBs that occurred on 7 April 2016 and on 27 September 2017. We found that the EPBs modulate the Pc1 wave propagation by setting up reflection boundaries and leakage holes in the ionospheric waveguide. We also found that changes of Pc1 wave intensities generally follow the electron density variation and that the intensity is stronger at higher density region. From the comparison between Swarm‐A and Swarm‐C observations, we conclude that ionospheric plasma plays an important role for Pc1 waveguide even though their density is significantly low in EPBs.