bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adoption of corporate governance practices in the computer science environment. Mexican food franchise analysis in the Colombian context
Authors: Virgüez J F , Castro Silva H F , Puentes Velásquez A M 
Published: November 2019

Abstract
In a globalized world characterized by aggressive competition in all sectors of the economy, it is essential that organizations establish adequate corporate governance in order to properly coordinate interests within the organization to generate wealth. One of the models associated with corporate governance is the balanced scorecard consisting of four perspectives. This work provides an important input to consider within the organizational goals in the perspective of the balanced scorecard client in Mexican food franchises in Cali - Colombia, as is the client’s knowledge. The research approach is mixed and predominantly descriptive. As a result of the study there is a consumer profile in Mexican food franchises in the city of Cali. Thus, the average consumer of Mexican food is a young person, of medium socioeconomic status and who shares in family the consumption of this type of food. In addition, the study identifies the main variables that determine the decision to consume Mexican food, such as the possibility of home shopping through mobile applications, hygiene and food presentation.
Real-time analysis as an alternative for diagnosis and control of vehicle emissions in the province of Ocaña, Colombia
Authors: Valdes-Solano D M , Fonseca-Herreño L C , Alba-Maldonado J M 
Published: November 2019

Abstract
In Colombia, the increasing use of motorcycles as an informal conveyance has emerge as a means of labor survival for people with limited resources. Mototaxism has rapidly become the main means of transport in the spatial structure of the city of Ocaña; however, high emission rates may present an environmental problem. The study and implementation of strategies for the mitigation of greenhouse gas, is of great help for the reduction of the emissions of these gases. Environmental control of vehicles in Colombia is carried out through an annual technical-mechanical and gas inspection, which seeks to control the emission of pollutant gases from vehicles; however, electrochemical gas sensors may provide an accurate and convenient alternative, as it can be implemented as an analytic tool in gas monitoring and control systems allowing different approaches for the control of vehicle exhaust emissions. A development board such as Arduino can be programmed with an algorithm that utilizes a combination of sensors and connectivity modules, constituting a microcontroller unit that is able to achieve successful monitoring over emission gases, one such algorithm is proposed by the authors.
Development of a virtual instrument for the calculation of thermal efficiency under the assumptions of standard cold air in a 3500cc diesel engine
Authors: Regino F J , Gómez JA , Jaramillo HY 
Published: November 2019

Abstract
This work presents the development of a virtual instrument for the acquisition of temperature data of a 3500 cc diesel engine and the calculation of its thermal efficiency at three different speeds, the analysis was made according to the standard cold air parameters for a diesel engine. To measure the temperature, type K thermocouples distributed around the combustion chamber and the engine exhaust was used; the data acquisition was carried out through a cDAQ-9178 and a NI-9213 thermocouple module from National Instruments.
Analysis of the mechanical characteristics in mortar mixtures with the incorporation of corn leaf fibers
Authors: Jaramillo H Y , Gallardo R J , Gómez J A 
Published: November 2019

Abstract
This article presents the results of an experimental design research work, aimed at adding the fibers of the corn leaf to the cement mortar matrix 1:3, performing tension and compression, humidity and density tests to determine the degree of final resistance of the new reinforced mortar. Once described the way in which the fiber of the corn leaf is acquired, the quantities of the elements of the mixture are detailed, and the results of three samples and the average obtained are disclosed.
Thermal stability and some thermodynamics analysis of heat treated quaternary CuAlNiTa shape memory alloy
Authors: Kök Mediha , Qader Ibrahim Nazem , Mohammed Safar Saeed , Öner Ecem , Dağdelen Fethi , Aydogdu Yildirim 
Published: November 2019

AbstractThis study presents the heat treatment effect on a quaternary Cu79Al13Ni4Ta4(wt%) shape memory alloy. The induction technique was used for melting the alloy and then four pieces of the alloy were heat-treated at (673 K, 873 K, 1073 K, and 1273 K) for one hour. Some physical parameters were characterized using DSC, XRD, and SEM-EDX. The as-cast and heat-treated samples were studied in terms of phase transformation temperatures, enthalpy change, entropy change, Gibbs free energy, and elastic energy. The transformation temperature was increased by applying heat treatment. Martensitic phase transformation at heat treatment temperature of 1273 K was not observed. Besides, after rising heat treatment temperature, some new phases such asϒ1′andβ1′were specified in XRD patterns and SEM images. Generally, for heat-treated samples, the transformation temperature remains almost constant after the 3rd cycle. However, the thermal stability of the as-cast alloy was not affected through thermal cycling.
The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas
Authors: Bongaarts Anika , van Scheppingen Jackelien , Korotkov Anatoly , Mijnsbergen Caroline , Anink Jasper J , Jansen Floor E , Spliet Wim G M , den Dunnen Wilfred F A , Gruber Victoria E , Scholl Theresa , Samueli Sharon , Hainfellner Johannes A , Feucht Martha , Kotulska Katarzyna , Jozwiak Sergiusz , Grajkowska Wieslawa , Buccoliero Anna Maria , Caporalini Chiara , Giordano Flavio , Genitori Lorenzo , Coras Roland , Blümcke Ingmar , Krsek Pavel , Zamecnik Josef , Meijer Lisethe , Scicluna Brendon P , Schouten-van Meeteren Antoinette Y N , Mühlebner Angelika , Mills James D , Aronica Eleonora 
Published: November 2019

AbstractTuberous sclerosis complex (TSC) is an autosomal dominantly inherited neurocutaneous disorder caused by inactivating mutations in TSC1 or TSC2, key regulators of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. In the CNS, TSC is characterized by cortical tubers, subependymal nodules and subependymal giant cell astrocytomas (SEGAs). SEGAs may lead to impaired circulation of CSF resulting in hydrocephalus and raised intracranial pressure in patients with TSC. Currently, surgical resection and mTORC1 inhibitors are the recommended treatment options for patients with SEGA. In the present study, high-throughput RNA-sequencing (SEGAs n = 19, periventricular control n = 8) was used in combination with computational approaches to unravel the complexity of SEGA development. We identified 9400 mRNAs and 94 microRNAs differentially expressed in SEGAs compared to control tissue. The SEGA transcriptome profile was enriched for the mitogen-activated protein kinase (MAPK) pathway, a major regulator of cell proliferation and survival. Analysis at the protein level confirmed that extracellular signal-regulated kinase (ERK) is activated in SEGAs. Subsequently, the inhibition of ERK independently of mTORC1 blockade decreased efficiently the proliferation of primary patient-derived SEGA cultures. Furthermore, we found that LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 were overexpressed at both gene and protein levels in SEGA compared to control tissue. Taken together LAMTOR1–5 can form a complex, known as the ‘Ragulator’ complex, which is known to activate both mTORC1 and MAPK/ERK pathways. Overall, this study shows that the MAPK/ERK pathway could be used as a target for treatment independent of, or in combination with mTORC1 inhibitors for TSC patients. Moreover, our study provides initial evidence of a possible link between the constitutive activated mTORC1 pathway and a secondary driver pathway of tumour growth.
Spatial distribution of interictal spikes fluctuates over time and localizes seizure onset
Authors: Conrad Erin C , Tomlinson Samuel B , Wong Jeremy N , Oechsel Kelly F , Shinohara Russell T , Litt Brian , Davis Kathryn A , Marsh Eric D 
Published: November 2019

AbstractThe location of interictal spikes is used to aid surgical planning in patients with medically refractory epilepsy; however, their spatial and temporal dynamics are poorly understood. In this study, we analysed the spatial distribution of interictal spikes over time in 20 adult and paediatric patients (12 females, mean age = 34.5 years, range = 5–58) who underwent intracranial EEG evaluation for epilepsy surgery. Interictal spikes were detected in the 24 h surrounding each seizure and spikes were clustered based on spatial location. The temporal dynamics of spike spatial distribution were calculated for each patient and the effects of sleep and seizures on these dynamics were evaluated. Finally, spike location was assessed in relation to seizure onset location. We found that spike spatial distribution fluctuated significantly over time in 14/20 patients (with a significant aggregate effect across patients, Fisher’s method: P &lt; 0.001). A median of 12 sequential hours were required to capture 80% of the variability in spike spatial distribution. Sleep and postictal state affected the spike spatial distribution in 8/20 and 4/20 patients, respectively, with a significant aggregate effect (Fisher’s method: P &lt; 0.001 for each). There was no evidence of pre-ictal change in the spike spatial distribution for any patient or in aggregate (Fisher’s method: P = 0.99). The electrode with the highest spike frequency and the electrode with the largest area of downstream spike propagation both localized the seizure onset zone better than predicted by chance (Wilcoxon signed-rank test: P = 0.005 and P = 0.002, respectively). In conclusion, spikes localize seizure onset. However, temporal fluctuations in spike spatial distribution, particularly in relation to sleep and post-ictal state, can confound localization. An adequate duration of intracranial recording—ideally at least 12 sequential hours—capturing both sleep and wakefulness should be obtained to sufficiently sample the interictal network.
Imagining the Perfect Asian Woman Through Hate: Michelle Phan, Anti-Phandom, and Asian Diasporic Beauty Cultures
Authors: Tran Tony 
Published: November 2019

AbstractThis article examines the predominately Asian American “Anti-Phandom” community on GuruGossiper.com to explore how anti-fans of YouTube star Michelle Phan engage with ideologies of beauty cultures within Asian diasporic contexts. For many, Anti-Phandom provides an online space where personal concerns about female Asian beauty standards can be negotiated through Michelle Phan. Within these conversations, I argue Anti-Phans display forms of resistance to Phan's postfeminist forms of female empowerment on racial and ethnic terms. However, these counters to Phan's notions of beauty also produce a rubric of the beautiful Asian woman which renders difference as ugly, creating idealized definitions of racial beauty and Asian/American cultures based on essentialized categories that police diasporic women.
Clinical Characteristics of Active Tuberculosis Diagnosed After Starting Treatment for Latent Tuberculosis Infection
Authors: Flynn Andrew G , Aiona Kaylynn , Haas Michelle K , Reves Randall , Belknap Robert 
Published: November 2019

Abstract
Although rare, subclinical tuberculosis disease can be missed during evaluations for latent tuberculosis infection, and can manifest with symptoms during latent tuberculosis treatment. Among over 8000 patients treated for latent tuberculosis we found no evidence of acquired drug resistance, underscoring the safety of rifampin monotherapy for latent tuberculosis.
Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease
Authors: Nakashima Yasutaka , Sakai Yasunari , Mizuno Yumi , Furuno Kenji , Hirono Keiichi , Takatsuki Shinichi , Suzuki Hiroyuki , Onouchi Yoshihiro , Kobayashi Tohru , Tanabe Kazuhiro , Hamase Kenji , Miyamoto Tomofumi , Aoyagi Ryohei , Arita Makoto , Yamamura Kenichiro , Tanaka Tamami , Nishio Hisanori , Takada Hidetoshi , Ohga Shouichi , Hara Toshiro 
Published: November 2019

Abstract

Aims
Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to the development of coronary arteritis in KD.

Methods and results
To identify causative molecules for coronary arteritis in KD, we prospectively recruited 105 patients with KD and 65 disease controls in four different parts of Japan from 2015 to 2018. During this period, we conducted lipidomics analyses of their sera using liquid chromatography–mass spectrometry (LC-MS). The comprehensive LC-MS system detected a total of 27 776 molecules harbouring the unique retention time and m/z values. In the first cohort of 57 KD patients, we found that a fraction of these molecules showed enrichment patterns that varied with the sampling region and season. Among them, 28 molecules were recurrently identified in KD patients but not in controls. The second and third cohorts of 48 more patients with KD revealed that these molecules were correlated with inflammatory markers (leucocyte counts and C-reactive proteins) in the acute stage. Notably, two of these molecules (m/z values: 822.55 and 834.59) were significantly associated with the development of coronary arteritis in the acute stage of KD. Their fragmentation patterns in the tandem MS/MS analysis were consistent with those of oxidized phosphatidylcholines (PCs). Further LC-MS/MS analysis supported the concept that reactive oxygen species caused the non-selective oxidization of PCs in KD patients. In addition, the concentrations of LOX-1 ligand containing apolipoprotein B in the plasma of KD patients were significantly higher than in controls.

Conclusion
These data suggest that inflammatory signals activated by oxidized phospholipids are involved in the pathogenesis of coronary arteritis in KD. Because the present study recruited only Japanese patients, further examinations are required to determine whether oxidized PCs might be useful biomarkers for the development of coronary arteritis in broad populations of KD.
Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease
Authors: Sharma Umakant , Olson Rohini Khatri , Erhart Federico Nicolas , Zhang Li , Meng Jingjing , Segura Bradley , Banerjee Santanu , Sharma Madhulika , Saluja Ashok Kumar , Ramakrishnan Sundaram , Abreu Maria T , Roy Sabita 
Published: November 2019

AbstractBackground and AimsOpioids are the most prescribed analgesics for pain in inflammatory bowel diseases [IBD]; however, the consequences of opioid use on IBD severity are not well defined. This is the first study investigating consequences of hydromorphone in both dextran sodium sulphate [DSS]-induced colitis and spontaneous colitis (IL-10 knockout [IL-10-/-]) mouse models of IBD.MethodsTo determine the consequences of opioids on IBD pathogenesis, wild-type [WT] mice were treated with clinically relevant doses of hydromorphone and colitis was induced via 3% DSS in drinking water for 5 days. In parallel we also determined the consequences of opioids in a spontaneous colitis model.ResultsHydromorphone and DSS independently induced barrier dysfunction, bacterial translocation, disruption of tight junction organisation and increased intestinal and systemic inflammation, which were exacerbated in mice receiving hydromorphone in combination with DSS. Hydromorphone + DSS-treated mice exhibited significant microbial dysbiosis. Predictive metagenomic analysis of the gut microbiota revealed high abundance in the bacterial communities associated with virulence, antibiotic resistance, toxin production, and inflammatory properties. Hydromorphone modulates tight junction organisation in a myosin light chain kinase [MLCK]-dependent manner. Treatment with MLCK inhibitor ML-7 ameliorates the detrimental effects of hydromorphone on DSS-induced colitis and thus decreases severity of IBD. Similarly, we demonstrated that hydromorphone treatment in IL-10-/- mice resulted in accelerated clinical manifestations of colitis compared with control mice.ConclusionsOpioids used for pain management in IBD accelerate IBD progression by dysregulation of the gut microbiota, leading to expansion of pathogenic bacteria, translocation of bacteria, immune deregulation and sustained inflammation.
Profiling the microbial community of a Triassic halite deposit in Northern Ireland: an environment with significant potential for biodiscovery
Authors: Megaw Julianne , Kelly Stephen A , Thompson Thomas P , Skvortsov Timofey , Gilmore Brendan F 
Published: November 2019

ABSTRACT
Kilroot salt mine, a Triassic halite deposit located in County Antrim, Northern Ireland, is the only permanent hypersaline environment on the island of Ireland. In this study, the microbiome of this unstudied environment was profiled for the first time using conventional and enhanced culturing techniques, and culture independent metagenomic approaches. Using both conventional isolation plates and iChip devices, 89 halophilic archaeal isolates from six known genera, and 55 halophilic or halotolerant bacterial isolates from 18 genera were obtained, based on 16S rRNA gene sequencing. The archaeal isolates were similar to those previously isolated from other ancient halite deposits, and as expected, numerous genera were identified in the metagenome which were not represented among the culturable isolates. Preliminary screening of a selection of isolates from this environment identified antimicrobial activities against a panel of clinically important bacterial pathogens from 15 of the bacterial isolates and one of the archaea. This, alongside previous studies reporting the discovery of novel biocatalysts from the Kilroot mine microbiome, suggests that this environment may be a new, untapped source of of chemical diversity with high biodiscovery potential.
A recruitment model for beech–oak pure and mixed stands in Belgium
Authors: Manso Rubén , Ligot Gauthier , Fortin Mathieu 
Published: November 2019

AbstractWe present a recruitment model for pure and mixed beech and oak stands in Belgium, the first empirical model for this forest type in this geographical area. Data from the Wallonia National Forest Inventory were used to fit the model. We adopted a zero-inflated formulation where model parameters governing species’ behaviour were simultaneously fitted. Plot random effects specific to each species were included, the simultaneous fit allowing them to correlate. Model predictions proved accurate and corresponded to current ecological knowledge about the regeneration dynamics of this kind of mixture. While our model could potentially be used to complement the existing beech and oak growth models for this region of Europe, our results also show that beech recruits tend to dominate regardless of the oak share in the overstorey composition and the stand stocking. This confirms that the beech–oak mixture may not be stable under the conditions of the study area and current management aimed at promoting continuous forest cover.
3-D crustal structure of the Iran plateau using phase velocity ambient noise tomography
Authors: Movaghari R , Doloei G Javan 
Published: November 2019

SUMMARY
More accurate crustal structure models will help us to better understand the tectonic convergence between Arabian and Eurasian plates in the Iran plateau. In this study, the crustal and uppermost mantle velocity structure of the Iran plateau is investigated using ambient noise tomography. Three years of continuous data are correlated to retrieve Rayleigh wave empirical Green's functions, and phase velocity dispersion curves are extracted using the spectral method. High-resolution Rayleigh wave phase velocity maps are presented at periods of 8–60 s. The tomographic maps show a clear consistency with geological structures such as sedimentary basins and seismotectonic zones, especially at short periods. A quasi-3-D shear wave velocity model is determined from the surface down to 100 km beneath the Iran plateau. A transect of the shear wave velocity model has been considered along with a profile extending across the southern Zagros, the Sanandaj-Sirjan Zone (SSZ), the Urumieh-Dokhtar Magmatic Arc (UDMA) and Central Iran and Kopeh-Dagh (KD). Obvious crustal thinning and thickening are observable along the transect of the shear wave velocity model beneath Central Iran and the SSZ, respectively. The observed shear wave velocities beneath the Iran plateau, specifically Central Iran, support the slab break-off idea in which low density asthenospheric materials drive towards the upper layers, replacing materials in the subcrustal lithosphere.
Access to paediatric cancer care treatment in Mexico: responding to health system challenges and opportunities
Authors: Doubova Svetlana V , Knaul Felicia Marie , Borja-Aburto Víctor Hugo , Garcia-Saíso Sebastian , Zapata-Tarres Marta , Gonzalez-Leon Margot , Sarabia-Gonzalez Odet , Arreola-Ornelas Héctor , Pérez-Cuevas Ricardo 
Published: November 2019

Abstract
In Mexico, paediatric cancer is the leading cause of death for children aged 0–18 years. This study analyses the main challenges for paediatric cancer care from the perspective of three key health systems functions: stewardship, financing and service delivery. The study used a mixed methods approach comprised of: (1) a scoping literature review, (2) an analysis of 2008–18 expenditures on paediatric cancer by the Fund for Protection against Catastrophic Expenditures (FPGC) of Seguro Popular and (3) a nation-wide survey of the supply capacity of 59 Ministry of Health (MoH) and 39 Mexican Institute of Social Security (IMSS) hospitals engaged in paediatric cancer care. The study found that while Mexico has made substantial progress towards universal health coverage (UHC) for paediatric cancer treatment, serious gaps persist. FPGC funds for paediatric cancer increased from 2008 to 2011 to reach US$36 million and then declined to US$13.6 million in 2018, along with the number of covered cases. The distribution of health professionals and paediatric oncology infrastructure is uneven between MoH and IMSS hospitals and across Mexican regions. Both institutions share common barriers for continuous and co-ordinated health care and lack monitoring activities that cripple their capacity to apply uniform standards for high-quality cancer care. In conclusion, achieving universal and effective coverage of paediatric cancer treatment is a critical component of UHC for Mexico. This requires periodic and ongoing assessment of health system performance specific to paediatric cancer to identify gaps and propose strategies for continued investment and improvement of access to care and health outcomes for this important cause of premature mortality.
Uniqueness of Real Lagrangians up to Cobordism
Authors: Kim Joontae 
Published: November 2019

AbstractWe prove that a real Lagrangian submanifold in a closed symplectic manifold is unique up to cobordism. We then discuss the classification of real Lagrangians in ${\mathbb {C}} P^2$ and $S^2\times S^2$. In particular, we show that a real Lagrangian in ${\mathbb {C}} P^2$ is unique up to Hamiltonian isotopy and that a real Lagrangian in $S^2\times S^2$ is either Hamiltonian isotopic to the antidiagonal sphere or Lagrangian isotopic to the Clifford torus.