bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Detection of Drift Resonance Between Energetic Electrons and Ultralow Frequency Waves: Multisatellite Coordinated Observation by Arase and Van Allen Probes
Authors: Teramoto M. , Hori T. , Saito S. , Miyoshi Y. , Kurita S. , Higashio N. , Matsuoka A. , Kasahara Y. , Kasaba Y. , Takashima T. , Nomura R. , Nosé M. , Fujimoto A. , Tanaka Y.‐M. , Shoji M. , Tsugawa Y. , Shinohara M. , Shinohara I. , Blake J. B. , Fennell J.F. , Claudepierre S.G. , Turner D. L. , Kletzing C. A. , Sormakov D. , Troshichev O. 
Published: November 2019

AbstractWe report the electron flux modulations without corresponding magnetic fluctuations from unique multipoint satellite observations of the Arase (Exploration of Energization and Radiation in Geospace) and the Van Allen Probe (Radiation Belt Storm Probe [RBSP])‐B satellites. On 30 March 2017, both Arase and RBSP‐B observed periodic fluctuations in the relativistic electron flux with energies ranging from 500 keV to 2 MeV when they were located near the magnetic equator in the morning and dusk local time sectors, respectively. Arase did not observe Pc5 pulsations, while they were observed by RBSP‐B. The clear dispersion signature of the relativistic electron fluctuations observed by Arase indicates that the source region is limited to the postnoon to the dusk sector. This is confirmed by RBSP‐B and ground‐magnetometer observations, where Pc5 pulsations are observed to drift‐resonate with relativistic electrons on the duskside. Thus, Arase observed the drift‐resonance signatures “remotely,” whereas RBSP‐B observed them “locally.”
Nickel-catalyzed intermolecular oxidative Heck arylation driven by transfer hydrogenation
Authors: Lv Honggui , Kang Huiying , Zhou Biying , Xue Xiaosong , Engle Keary M. , Zhao Dongbing 
Published: November 2019

AbstractThe conventional oxidative Heck reaction between aryl boronic acids and alkenes typically involved the PdII/Pd0/PdII catalytic cycle incorporating an external oxidant and often suffered C=C bond isomerization for internal alkyl-substituted alkenes via chain-walking. Herein, we demonstrate that the regioselectivity (γ-selectivity vs. δ-selectivity) and pathway selectivity (hydroarylation vs. oxidative Heck coupling) of a directed Ni-catalyzed alkene arylation can be controlled by judicious tuning of the coordination environment around the nickel catalyst via optimization of an appropriate phosphine ligand and directing group. In this way, the Ni(0)-catalyzed oxidative Heck arylation that relies on transfer hydrogenation of an acceptor olefin is developed with excellent E/Z selectivity and regioselectivity. Mechanistic investigations suggest that the addition of the acceptor is crucial for lowering the energy for carbometalation and for enabling catalytic turnover.
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Authors: Liu Pei Y. , Tee Andrew E. , Milazzo Giorgio , Hannan Katherine M. , Maag Jesper , Mondal Sujanna , Atmadibrata Bernard , Bartonicek Nenad , Peng Hui , Ho Nicholas , Mayoh Chelsea , Ciaccio Roberto , Sun Yuting , Henderson Michelle J. , Gao Jixuan , Everaert Celine , Hulme Amy J. , Wong Matthew , Lan Qing , Cheung Belamy B. , Shi Leming , Wang Jenny Y. , Simon Thorsten , Fischer Matthias , Zhang Xu D. , Marshall Glenn M. , Norris Murray D. , Haber Michelle , Vandesompele Jo , Li Jinyan , Mestdagh Pieter , Hannan Ross D. , Dinger Marcel E. , Perini Giovanni , Liu Tao 
Published: November 2019

AbstractThe majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts most over-expressed in MYCN-amplified, compared with MYCN-non-amplified, human neuroblastoma cells and also the most over-expressed in neuroblastoma compared with all other cancers. lncNB1 binds to the ribosomal protein RPL35 to enhance E2F1 protein synthesis, leading to DEPDC1B gene transcription. The GTPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization. Importantly, lncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma tumor regression in mice, while high levels of lncNB1 and RPL35 in human neuroblastoma tissues predict poor patient prognosis. This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets.
Spatial Multiplexing Technique for Improving Dynamic Range of Speckle Correlation based Optical Lever
Authors: Anand Vijayakumar , Bhattacharya Shanti , Rosen Joseph 
Published: November 2019

AbstractSpeckle correlation based optical levers (SC-OptLev) possess attractive characteristics suitable for sensing small changes in the angular orientations of surfaces. In this study, we propose and demonstrate a spatial multiplexing technique for improving the dynamic range of SC-OptLev. When the surface is in its initial position, a synthetic speckle intensity pattern, larger than the area of the image sensor is created by transversely shifting the image sensor and recording different sections of a larger speckle pattern. Then, the acquired images are stitched together by a computer program into one relatively large synthetic speckle pattern. Following the calibration stage, the synthetic speckle intensity pattern is used to sense changes in the surface’s angular orientation. The surface is monitored in real-time by recording part of the speckle pattern which lies within the sensor area. Next, the recorded speckle pattern is cross-correlated with the synthetic speckle pattern in the computer. The resulting shift of the correlation peak indicates the angular orientations of the reflective surface under test. This spatial-multiplexing technique enables sensing changes in the angular orientation of the surface beyond the limit imposed by the physical size of the image sensor.
Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation
Authors: Enomoto Atsushi , Fukasawa Takemichi , Tsumoto Hiroki , Karube Masataka , Nakagawa Keiichi , Yoshizaki Ayumi , Sato Shinichi , Miura Yuri , Miyagawa Kiyoshi 
Published: November 2019

AbstractSerine-threonine kinase 38 (STK38) is a member of the protein kinase A (PKA)/PKG/PKC-family implicated in the regulation of cell division and morphogenesis. However, the molecular mechanisms underlying STK38 stability remain largely unknown. Here, we show that treatment of cells with either heat or the calcium ionophore A23187 induced STK38 degradation. The calpain inhibitor calpeptin suppressed hyperthermia-induced degradation or the appearance of A23187-induced cleaved form of STK38. An in vitro cleavage assay was then used to demonstrate that calpain I directly cleaves STK38 at the proximal N-terminal region. Deletion of the N-terminal region of STK38 increased its stability against hyperthermia. We further demonstrated that the MAPKK kinase (MAP3K) MEKK2 prevented both heat- and calpain-induced cleavage of STK38. MEKK2 knockdown enhanced hyperthermia-induced degradation of STK38. We performed an in vitro MEKK2 assay and identified the key regulatory site in STK38 phosphorylated by MEKK2. Experiments with a phosphorylation-defective mutant demonstrated that phosphorylation of Ser 91 is important for STK38 stability, as the enzyme is susceptible to degradation by the calpain pathway unless this residue is phosphorylated. In summary, we demonstrated that STK38 is a calpain substrate and revealed a novel role of MEKK2 in the process of STK38 degradation by calpain.
Bisphenol S and Bisphenol A disrupt morphogenesis of MCF-12A human mammary epithelial cells
Authors: Atlas Ella , Dimitrova Valeria 
Published: November 2019

AbstractBreast cancer is one of the most common cancers diagnosed in women worldwide. Genetic predisposition, such as breast cancer 1 (BRCA1) mutations, account for a minor percentage of the total breast cancer incidences. And thus, many life style factors have also been linked to the disease such as smoking, alcohol consumption and obesity. Emerging studies show that environmental pollutants may also play a role. Bisphenol-A (BPA) has been suspected to contribute to breast cancer development, and has been shown to affect mammary gland development amongst other effects. This prompted its replacement with other bisphenol analogs such as, bisphenol-S (BPS). In this study we used the human mammary epithelial cells, MCF-12A, grown in extracellular matrix to investigate the ability of BPA and BPS to disrupt mammary epithelial cells organization. We show that both BPA and BPS were equipotent in disrupting the organization of the acinar structures, despite BPS being less oestrogenic by other assays. Further, treatment with both compounds enabled the cells to invade the lumen of the structures. This study shows that BPS and BPA are environmental pollutants that may affect mammary development and may contribute to the development of breast cancer.
Assessment of the optimal cutoff value of fasting plasma glucose to establish diagnosis of gestational diabetes mellitus in Chinese women
Authors: Yan Bing , Yu Ya-xin , Chen Yin-ling , Su Wei-juan , Huang Yin-xiang , Zhang Mu-lin , Huang Bing-kun , Han Li-li , Song Hai-qu , Li Xue-jun 
Published: November 2019

AbstractOur aim is to assess the optimal cutoff value of fasting plasma glucose (FPG) in Chinese women at 24–28 weeks’ gestation by performing oral glucose tolerance test (OGTT) to improve diagnostic rate of gestational diabetes mellitus (GDM). Data were derived from the Medical Birth Registry of Xiamen. A FPG cutoff value of 5.1 mmol/L confirmed the diagnosis of GDM in 4,794 (6.10%) pregnant women. However, a FPG cutoff value of 4.5 mmol/L should rule out the diagnosis of GDM in 35,932 (45.73%) pregnant women. If we use this cutoff value, the diagnosis of GDM to about 27.3% of pregnant women will be missed. Additionally, a 75-g OGTT was performed in pregnant women with FPG values between 4.5 and 5.1 mmol/L, avoiding the performance of formal 75-g OGTT in about 50.37% pregnant women. Meanwhile, according to maternal age and pre-pregnancy BMI categories, with FPG values between 4.5 mmol/L and 5.1 mmol/L, which had high sensitivity, to improve the diagnostic rate of GDM in all groups. Further researches are needed to present stronger evidences for the screening value of FPG in establishing the diagnosis of GDM in pregnant women.
DISCOVER: A facile structure-based screening method for vinyl compound producing microbes
Authors: Aso Yuji , Sano Mei , Kuroda Hikari , Ohara Hitomi , Ando Hiroshi , Matsumoto Keiji 
Published: November 2019

AbstractHere we report a novel structure-based microbial screening method for vinyl compound discovery, DISCOVER (direct screening method based on coupling reactions for vinyl compound producers). Through a two-step screening procedure based on selective coupling reactions of terminal alkenes, the thiol-ene reaction (1st step of screening) and Mizoroki-Heck reaction, followed by iodine test (2nd step of screening), microbes producing vinyl compounds like itaconic acid (IA) can be isolated from soil samples. In the 1st step of screening, soil sources are plated on agar medium supplemented with an antimicrobial agent, α-thioglycerol (TG), and a radical initiator, VA-044 (VA). In the 2nd step of screening, vinyl compounds produced in the cultures are labelled with iodobenzene via the Mizoroki-Heck reaction, followed by an iodine test, leading to the detection and characterisation of labelled products. We evaluated the validity of DISCOVER using IA and its producer Aspergillus terreus. Experimental data supported our hypothesis that IA reacts with TG in the medium via the thiol-ene reaction and consequently, A. terreus rapidly forms colonies on the agar medium because of the loss of the antimicrobial activity of TG. Using DISCOVER, high throughput and selective isolation of A. terreus strains producing IA was possible from soils.
Comparison study between mesoporous silica nanoscale microsphere and active carbon used as the matrix of shape-stabilized phase change material
Authors: Zhang Zijun , Wang Jingxing , Tang Xi , Liu Yi , Han Zhi , Chen Yan 
Published: November 2019

AbstractMesoporous silica nanoscale microsphere (MSNM), with a special morphology, high porosity, large pore volume and specific surface area, was successfully prepared and used as the matrix material of lauric acid (LA) to prepare a favorable shape-stabilized phase change material (LA/MSNM). The porous network structure of MSNM is effective to prevent the leakage and enhance the thermal stability of LA/MSNM. For comparison, shape-stabilized phase change material of LA/AC, which contained commercially purchased active carbon (AC) and LA, was prepared by the same method. Characterizations of LA/MSNM and LA/AC, such as chemical properties, structure, thermal properties and crystallization properties were studied. The mechanisms of interaction between LA molecules and MSNM or AC were explicated. The results of TGA test showed that the LA/MSNM and LA/AC had superior thermal stability, and however, the melting and solidification enthalpies of LA/MSNM were much higher than that of LA/AC, which was attributed that the loading capacity of MSNM was better than that of LA/AC. All of the study results demonstrated that the mesoporous silica nanoscale microspheres of MSNM synthesized in this study possessed the potential for practical applications as a suitable supporter of organic phase change materials.
Adsorption characteristics of Pb(II) using biochar derived from spent mushroom substrate
Authors: Wu Qianlan , Xian Yang , He Zilin , Zhang Qi , Wu Jun , Yang Gang , Zhang Xiaohong , Qi Hui , Ma Jing , Xiao Yinlong , Long Lulu 
Published: November 2019

AbstractAs a multifunctional material, biochar is considered a potential adsorbent for removing heavy metals from wastewater. Most biochars with high adsorption capacities have been modified, but this modification is uneconomical, and modifying biochar may cause secondary pollution. Thus, it is necessary to develop an efficient biochar without modification. In this study, spent P. ostreatus substrate and spent shiitake substrate were used as the raw materials to prepare biochar. Then, the physicochemical properties of the biochars and their removal efficiencies for Pb(II) were investigated. The results showed that the physicochemical properties (e.g., large BET surface area, small pore structure and abundant functional groups) contributed to the large adsorption capacity for Pb(II); the maximum adsorption capacities were 326 mg g−1 (spent P. ostreatus substrate-derived biochar) and 398 mg g−1 (spent shiitake substrate-derived biochar), which are 1.6–10 times larger than those of other modified biochars. The Pb(II) adsorption data could be well described by the pseudo-second-order kinetic model and the Langmuir model. This study provides a new method to comprehensively utilize spent mushroom substrates for the sustainable development of the edible mushroom industry.
Effect of Text-to-Speech Rate on Reading Comprehension by Adults With Aphasia
Authors: Hux Karen , Brown Jessica A. , Wallace Sarah , Knollman-Porter Kelly , Saylor Anna , Lapp Erica 
Published: November 2019

Purpose
Accessing auditory and written material simultaneously benefits people with aphasia; however, the extent of benefit as well as people's preferences and experiences may vary given different auditory presentation rates. This study's purpose was to determine how 3 text-to-speech rates affect comprehension when adults with aphasia access newspaper articles through combined modalities. Secondary aims included exploring time spent reviewing written texts after speech output cessation, rate preference, preference consistency, and participant rationales for preferences.

Method
Twenty-five adults with aphasia read and listened to passages presented at slow (113 words per minute [wpm]), medium (154 wpm), and fast (200 wpm) rates. Participants answered comprehension questions, selected most and least preferred rates following the 1st and 3rd experimental sessions and after receiving performance feedback, and explained rate preferences and reading and listening strategies.

Results
Comprehension accuracy did not vary significantly across presentation rates, but reviewing time after cessation of auditory content did. Visual data inspection revealed that, in particular, participants with substantial extra reviewing time took longer given fast than medium or slow presentation. Regardless of exposure amount or receipt of performance feedback, participants most preferred the medium rate and least preferred the fast rate; rationales centered on reading and listening synchronization, benefits to comprehension, and perceived normality of speaking rate.

Conclusion
As a group, people with aphasia most preferred and were most efficient given a text-to-speech rate around 150 wpm when processing dual modality content; individual differences existed, however, and mandate attention to personal preferences and processing strengths.
A Decade of Collaboration Among International Representatives of the International Cluttering Association
Authors: Reichel Isabella , Ademola-Sakoya Grace , Aumont Boucand Véronique , Bona Judit , Carmona Jaqueline , Cosyns Marjan , Filatova Yulia , Haj-Tas Maisa , Kelkar Pallavi , Remman Reina , Miyamoto Shoko , Ozdemir Sertan , Sanghi Maya , Schnell Alexandra , de Touzet Beatriz Biain , Yang Shu-Lan 
Published: November 2019

Purpose
This article presents a collaborative initiative of members of the Committee of the International Representatives of the International Cluttering Association (ICA) upon celebrating the 10th anniversary of the ICA. Such collaborative efforts are designed to improve communication skills, enlighten lives of people with cluttering, and serve as models for speech therapists and other health care professionals in countries around the globe.

Method
This initiative began with a seminar at the Inaugural Joint World Congress in Japan in 2018 and continues with an article for this special issue on cluttering based on the contents of the papers presented at the Congress. Sixteen researchers and speech therapists from 15 countries in Africa, Asia, Europe (East and West), America (North and South), and the Middle East have explored the following themes related to cluttering: cluttering awareness, research, professional preparation, intervention, and self-help groups.

Results
This article adds to the body of international literature on cluttering and illustrates that, for the past 10 years, hypothesis-testing research in cluttering continues to be conducted across language barriers and national boundaries, and interventions that are implemented in some locales are being tested and taught in other parts of the world; furthermore, new cluttering treatments are being disseminated for professional preparation and clinical practices.

Conclusions
This article demonstrates how global engagement of the ICA's international representatives has led to the exchange of ideas about awareness of cluttering and professional preparation and the best strategies for the treatment of this communication disorder in countries around the world.
Reflection of Seismic and Solar Irregularities in Hydrogeological Fields of Kyrgyzstan
Authors: Kendirbaeva Jumagul 
Published: November 2019

The unity of exogenous and endogenous components in the regime of hydrogeological fields of Kyrgyzstan is shown on the basis of the addition of the index of solar activity as a participant in the system of «atmospheric–cosmic phenomena–groundwater– earthquakes».
The output of changes in concentration in hydrogeological fields beyond both the minimum and maximum levels is divided into a system with stable and unstable equilibria. Various effects in a water-gas mixture are associated with inhomogeneous paths of their penetration, including from solar activity. It is believed that taking this into account can serve as the basis for the integration of methods based on the theory of pulsating earth and reflection theory in the search for harbingers of natural disasters.
Is the Preoperative Glycated Hemoglobin (HbA1c) Level Predictive of
the Severity of Diabetic Hand Infection According to Surgical and Clinical
Outcomes?
Authors: Gürbüz Kaan , Ekinci Yakup 
Published: November 2019

Abstract
Objective We purposed to investigate whether preoperative HbA1c level
is associated with the severity of surgical treatment in diabetic hand
infection cases.
Materials and Methods Between December 2015 and October 2018, 102
patients were surgically treated due to diabetic hand infection. Of the
patients, 75 who met the criteria for diabetic hand infection were included
in the study. The patients were divided into two groups: Group 1, < 8.5%
HbA1c level (poorly controlled); and Group 2, 8.5% or higher HbA1c level
(uncontrolled). Preoperative, intraoperative, and postoperative data were
recorded. Drainage, VAC, ray/open amputation, and microsurgical
reconstruction were performed according to the examination and clinical
findings. p<0.05 was considered statistically significant.
Results The study groups consisted of 41 patients (5 female/36 male;
median age 59 years, range 32–68) in Group 1 and 34 patients (6 female/28
male; median age 62 years, range 28–67) in Group 2. The mean follow-up
period was 21.14±10.42 months in Group 1 and 16.70±10.19 months in Group 2,
which were not significantly different (p>0.05). The most common
microbiological pathogen was polymicrobial in both study groups (39% in
Group 1 and 41.2% in Group 2). Drainage was the most common surgical
procedure in both groups and there was no significant difference between the
groups in terms of the surgical techniques that were used (p>0.05).
Conclusion Although HbA1c level is an important biomarker for
monitoring glycemia in diabetic patients, it is not associated with the
severity of surgical treatment in diabetic hand infections.
A Simple Approach to Adjust for Case-Mix When Comparing Institutional Cesarean Birth Rates
Authors: Howbert James Jeffry , Kauffman Ellen , Sitcov Kristin , Souter Vivienne 
Published: November 2019

Abstract
Objective This study aimed to develop a validated model to predict intrapartum cesarean in nulliparous women and to use it to adjust for case-mix when comparing institutional laboring cesarean birth (CB) rates.
Study Design This multicenter retrospective study used chart-abstracted data on nulliparous, singleton, term births over a 7-year period. Prelabor cesareans were excluded. Logistic regression was used to predict the probability of CB for individual pregnancies. Thirty-five potential predictive variables were evaluated including maternal demographics, prepregnancy health, pregnancy characteristics, and newborn weight and gender. Models were trained on 21,017 births during 2011 to 2015 (training cohort), and accuracy assessed by prediction on 15,045 births during 2016 to 2017 (test cohort).
Results Six variables delivered predictive success equivalent to the full set of 35 variables: maternal weight, height, and age, gestation at birth, medically-indicated induction, and birth weight. Internal validation within the training cohort gave a receiver operator curve with area under the curve (ROC-AUC) of 0.722. External validation using the test cohort gave ROC-AUC of 0.722 (0.713–0.731 confidence interval). When comparing observed and predicted CB rates at 16 institutions in the test cohort, five had significantly lower than predicted rates and three had significantly higher than predicted rates.
Conclusion Six routine clinical variables used to adjust for case-mix can identify outliers when comparing institutional CB rates.