bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of leptin levels in neonates born to mothers with high or low gestational weight gain
Authors: Vargas-Aguirre Paulina , Tene Carlos E. , Del Toro-Equihua Mario , Bayardo-Tortolero Rosalinda , Sánchez-Meza Karmina 
Published: March 2020

AbstractBackgroundGestational weight gain (GWG) influences both fetal and maternal health. Leptin is a biomarker that may predict the early development of obesity and greater weight gain in childhood. Newborns with higher neonatal weight have been found to have higher leptin levels in umbilical cord blood (UCB). There are few studies that evaluate leptin levels in UCB according to GWG in women with a normal body mass index (BMI). The aim of the present study was to determine whether the levels of leptin in UCB in neonates born to mothers with a high GWG were higher, compared with levels in newborns whose mothers had a low GWG.MethodsA cross-sectional analytic study was conducted on 65 primigravidas. They were under 30 years of age, had normal pregestational BMIs, no associated diseases and were classified as having high (n = 22) or low (n = 43) GWG. The neonatal UCB leptin levels were measured and both neonatal and maternal anthropometric evaluations were carried out. The quantitative variables were compared through the Mann-Whitney U test and Student’s t test, as appropriate.ResultsUCB leptin levels were higher in the neonates whose mothers were in the high GWG group, compared with those born to mothers in the low GWG group (7.0 [1.9–11.4] vs. 2.9 [1.2–6.7] ng/mL, p = 0.020). When stratified by sex, that difference was maintained only in male neonates.ConclusionsUCB leptin levels were higher in neonates born to mothers with a high GWG, compared with those in newborns whose mothers had a low GWG.
Anpassungsmaßnahmen zur Reduktion von Klimawandel-induzierten Gesundheitsrisiken in Österreich: Schwerpunkt Überschwemmungen
Authors: Wallner Peter , Lemmerer Kathrin , Hutter Hans-Peter 
Published: March 2020

Zusammenfassung
Mit dem Klimawandel ist in Österreich eine Zunahme bei Intensität und Häufigkeit von Extremwetterereignissen wie Starkregen zu erwarten. Damit verbunden sind neben direkten Gesundheitsrisiken auch indirekte Effekte von Überschwemmungen, etwa psychosoziale Folgen, die bisher wenig im Fokus der Aufmerksamkeit stehen. Im Aktionsplan zur Österr. Strategie zur Anpassung an den Klimawandel werden Maßnahmen zur Erweiterung des Schutzes vor Naturgefahren vorgeschlagen. Eine explizite Einbeziehung von Klimawandelaspekten und dem Umgang damit ist bisher im Katastrophenmanagement kaum verankert.
Climate change – a still neglected topic in medicine and public health programs?
Authors: Grojsman Rébecca , Schütte Stefanie , Depoux Anneliese , Flahault Antoine 
Published: March 2020

Abstract
Health professionals are well placed to play a key role in educating people about climate and health. This article maps existing climate change education in medical as well as public health programs, identifies gaps and proposes possible improvements. It is essential that climate and health education enter the broader curriculum as this will also be a foundational part of education and help build the next generation of global expertise needed to create a healthier and more sustainable future.
Klimapolitik als Chance für bessere Gesundheit
Authors: von Philipsborn Peter , Wabnitz Katharina , Sell Kerstin , Maintz Eva , Rehfuess Eva , Gabrysch Sabine 
Published: March 2020

Zusammenfassung
Die Jugendbewegung Fridays for Future und KlimawissenschaftlerInnen fordern entschiedenes Handeln für den Klimaschutz. Die notwendige Umgestaltung der Gesellschaft ist eine Chance für das Schaffen von Lebensbedingungen, welche die physische und psychische Gesundheit von Menschen umfassend zur Entfaltung bringen. Anhand von drei Beispielen werden im vorliegenden Beitrag Win-Win-Ansätze dargestellt, die synergistisch die Gesundheit von Menschen und den Erhalt ihrer natürlichen Umwelt schützen und fördern.
Organoprotective Eﬀects of Extracorporeal Membrane Oxygenation and Intra-Aortic Balloon Pump in High-Risk Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome
Authors: Kornelyuk R. A. , Shukevich D. L. , Vereshchagin I. E. , Ganyukov V. I. 
Published: March 2020

Purpose of the study: to evaluate the organoprotective eﬀects of veno-arterial extracorporeal membrane oxygenation and intra-aortic balloon pump during high-risk percutaneous coronary intervention in acute coronary syndrome.Materials and methods. Patients required mechanical circulatory support (n=51) were divided into two study groups: patients who received mechanical circulatory support by veno-arterial extracorporeal membrane oxygenation (ECMO) (Group 1, n=29) during high-risk percutaneous coronary intervention, and Group 2 patients who received mechanical circulatory support by intra-aortic balloon pump (IABP) during high-risk percutaneous coronary intervention (Group 2, n=22). The dynamics of instrumental parameters and laboratory markers of organ damage were evaluated by electrocardiography, echocardiography, determining troponin I, creatine phosphokinases and creatinine levels, NGAL, venous blood saturation to compare the organoprotective properties of mechanical circulation support in the intra- and postoperative period.Results. The following values of the parameters were found the next day after the intervention: troponin I — 0.18 (0.1; 2.3) ng/ml in the ECMO group and 1.64 (0.92; 2.36) ng/ml in the IABP group (P=0.045); serum NGAL —139.4 (88.1; 166.7) ng/ml in the ECMO group and 212.3 (102; 279) in the IABP group (P=0.027); renal dysfunction (stages R, I, F according to RIFLE) — 2 (6.8%) observations in the ECMO group and 7 (31.8%) in the IABP group (P=0.021); multiple organ failure (2 or more points according to SOFA) — 3 (10.3%) cases in the ECMO group and 12 (54.5%) in the IABP group (P=0.001).Conclusion. Veno-arterial ECMO in comparison with IABP has a more pronounced organoprotective eﬀect by achieving better hemodynamic stability, which, in turn, prevents hypoxia and the subsequent development of organ dysfunction. In addition, in conditions of veno-arterial ECMO, better completeness and quality of revascularization is ensured, and hospital mortality is also reduced.
Combined Xenon and Epidural Anesthesia During Surgical Correction of Joint Deformities in the Lower Extremities of Children with Cerebral Palsy
Authors: Adkina E. A. , Ayzenberg V. L. , Iakovleva E. S. , Gudilina O. N. , Diordiev A. V. 
Published: March 2020

Objectives. The objective of this study is to compare diﬀerent methods of combination general and regional anesthesia based on xenon.Materials and methods. Xenon anesthesia combined with epidural block was performed in 50 children with cerebral palsy aged 3–17 years. In 30 patients xenon was used to maintain anesthesia, in 20 children xenon was combined with sevoﬂurane. We compared the process of anesthesia, the intraoperative hemodynamic parameters and cognitive status before surgery and after it.Results. The use of xenon in all studied anesthesia methods increased the cardiac performance and was associated with a stable hemodynamic proﬁle at all stages of anesthesia despite the depressive eﬀect of epidural blockade on hemodynamics. Psychological testing revealed that xenon anesthesia has no negative eﬀect on cognitive functions in children with cerebral palsy.Conclusion. Xenon anesthesia is a promising trend in anesthesia care for children with cerebral palsy. Xenon can compensate the hemodynamic depression caused by epidural anesthesia due to its cardiac stimulant property, with no neurotoxicity being a signiﬁcant beneﬁt for children with initial damage of CNS. However, anesthesia with xenon turned out to have some disadvantages. In our study, xenon showed insuﬃcient analgesic properties, had emetic properties and was associated with spirometric abnormalities. It was more diﬃcult to maintain normal ventilation parameters in young children when using xenon. Several adverse events were noted in the recovery period. These disadvantages can be partially reduced by using a combination of xenon and sevoﬂurane.
PEDAGOGICAL CONTENT KNOWLEDGE PROFILE OF PROSPECTIVE CHEMISTRY TEACHER
Authors: Feronika Tonih 
Published: March 2020

PROFIL PEDAGOGICAL CONTENT KNOWLEDGE CALON GURU KIMIAAbstractIn 2013 Dilek Karışan and Ayşe Şenay conducted experiments to investigate the Pedagogical Content Knowledge (PCK) of science teachers from Turkey that resulted in good teacher involvement determining the optimal formation of Content Knowledge in curriculum achievement, knowledge improvement and students are ready to learn. Chemical Education Study Program of UIN Syarif Hidayatullah Jakarta, Chemistry teacher who must have pedagogic and professional competence, to get concrete information from student's competence as the basis for developing KKNI curriculum of Chemistry Education Study Program. Therefore, the researcher will describe Pedagogical Content Knowledge Profile of pree-service Chemistry Teacher. Through qualitative descriptive method Mastery of PCK understanding by analyzing the answer of test result using Certainty of Response Index Criteria (CRI). Result of research PCK prospective teacher of chemistry is to know concept (49,7%) and misconceptions (50.3%). Based on the concept of chemistry of prospective teachers is to know the concept (40.4%) and do not know the concept (59.6%). This result is a consideration of the Institute for Educational Teaching Program (LPTK), especially the Chemistry Education Study Program as the basis for developing the KKNI Curriculum in the preparation of Learning Outcome Study and Leson Plan of Study. AbstrakPada tahun 2013 Dilek Karışan dan Ayşe Şenay melakukan eksperimen mengivestigasi Pedagogical Content Knowledge (PCK) guru sains dari di Turki dihasilkan bahwa kertelibatan guru secara baik menentukan pembentukan Content Knowledge secara optimum dalam pencapaian kurikulum, peningkatan pengetahuan dan siswa siap untuk belajar. Program Studi Pendidikan Kimia UIN Syarif Hidayatullah Jakarta mencetak calon Guru kimia yang harus memiliki kompetensi pedagogik dan professional,untuk mendapatkan informasi kongkrit dari kompetensi mahasiswa sebagai dasar untuk mengembangkan kurikulum KKNI Program Studi Pendidikan Kimia. Maka dengan ini peneliti akan mendeskripsikan Profil Pedagogical Content Knowledge Calon Guru Kimia.. Melalui metode deskriptif kualitatif Penguasaan pemahaman PCK dengan menganalisis Jawaban hasil tes menggunakan Kriteria Certainty of Response Index (CRI), Hasil penelitian Profil PCK calon guru kimia adalah tahu konsep (49,7%) dan miskonsepsi (50,3%). Berdasarkan pengusaan konsep kimia calon guru adalah tahu konsep (40,4%) dan tidak tahu konsep (59,6%). Hasil ini menjadi pertimbangan terhadap Lembaga Pendidikan Tenaga Kependidikan (LPTK) khususnya Program Studi Pendidikan Kimia sebagai dasar dalam mengembangkan Kurikulum KKNI dalam penyusunan Learning Outcome Program studi dan Rencana Perkuliah Semester.
ARGUMENTASI ILMIAH DAN KETERAMPILAN BERPIKIR KRITIS MELALUI METODE DEBAT
Authors: Suraya Suraya , Setiadi Anandita Eka , Muldayanti Nuri Dewi 
Published: March 2020

SCIENTIFIC ARGUMENTATION AND CRITICAL THINKING SKILLS TROUGH DEBATE METHODS AbstractLack of self-confidence and weak student reasoning in biology learning are related to scientific argumentation skills and critical thinking skills. This study aims to examine scientific argumentation and critical thinking skills of class X students in MAN 1 Natuna through debate methods on biodiversity material. This study uses a qualitative approach with descriptive methods. Data collection using observation, interviews, and documentation. Assessment of scientific argumentation and critical thinking was done oral and written. Scientific argumentation skills refer to Toulmin's Argument Pattern (TAP) and critical thinking skills are categorized in Strong, Acceptable, Unacceptable, & Weak. The results showed that student' scientific argumentation skills were at levels 2, 3, and 4. None of the students were at levels 1 and 5. Students' critical thinking skills were in the Unacceptable (62.06%) and Acceptable (37.94% ) category. Scientific arguments and critical thinking of class X students at MAN 1 Natuna are low. AbstrakKurangnya kepercayaan diri serta lemahnya penalaran siswa pada pembelajaran biologi berkaitan dengan keterampilan argumentasi ilmiah dan keterampilan berpikir kritis. Penelitian ini bertujuan untuk menguji keterampilan argumentasi ilmiah dan keterampilan berpikir kritis siswa kelas X di MAN 1 Natuna melalui metode debat pada materi keanekaragaman hayati. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Penilaian keterampilan argumentasi ilmiah dan berpikir kritis dilakukan secara lisan & tulisan. Keterampilan argumentasi ilmiah siswa mengacu pada Toulmin’s Argument Pattern (TAP), sedangkan keterampilan berpikir kritis dikategorikan dalam Strong, Acceptable, Unacceptable, & Weak. Hasil penelitian menunjukkan, keterampilan argumentasi ilmiah siswa berada pada level 2, 3, dan 4. Tidak ada satupun siswa yang berada pada level 1 dan 5. Keterampilan berpikir kritis siswa pada kategori Unacceptable (62.06%) dan Acceptable (37.94%). Argumentasi ilmiah dan berpikir kritis siswa kelas X di MAN 1 Natuna tergolong masih rendah.
KREATIVITAS DAN PENGETAHUAN SISWA PADA MATERI ASAM-BASA MELALUI PENERAPAN PROJECT BASED LEARNING DENGAN PRODUK KREATIF TERI PUTER
Authors: Khumaeroh Nailissatin , Sumarni Woro 
Published: March 2020

STUDENTS’ CREATIVITY AND KNOWLEDGE ON ACID-BASE TOPIC THROUGH THE APPLICATION OF PROJECT-BASED LEARNING WITH TERI PUTER CREATIVE PRODUCTS AbstractCreativity is one of the most needed competencies in the 21st century. This study aims to analyze students' creativity and knowledge on acid-base material through the application of Project Based Learning with Teri Puter Creative Products. The study was conducted at SMA Negeri 1 Bae Kudus with 35 research subjects in class XI MIPA 6 in the 2018/2019 school year. Data collection techniques using test and non-test instruments that have been declared valid and reliable. The results showed as many as 74% of students were in creative criteria and were very creative with the highest percentage in the originality indicator and the lowest percentage in the fluency indicator, while for the ability of knowledge by 40% who had good criteria and very good. The highest achievement is on the indicator to calculate the pH of acid-base solution and the lowest achievement on the indicator to calculate the concentration of [H+] and [OH-] in the solution. Positive responses are given by students with project based learning that has been applied. AbstrakKreativitas merupakan salah satu kompetensi yang amat dibutuhkan pada abad ke-21. Penelitian ini bertujuan untuk menganalisis kreativitas dan pengetahuan siswa pada materi asam-basa melalui penerapan Project Based Learning dengan Produk Kreatif Teri Puter. Penelitian dilaksanakan di SMA Negeri 1 Bae Kudus dengan subjek penelitian sebanyak 35 siswa kelas XI MIPA 6 pada tahun ajaran 2018/2019. Teknik pengumpulan data menggunakan instrumen tes dan non tes yang telah dinyatakan valid dan reliabel. Hasil penelitian menunjukkan sebanyak 74% siswa berada pada kriteria kreatif dan sangat kreatif dengan persentase tertinggi pada indikator originality dan persentase terendah pada indikator fluency, sedangkan untuk kemampuan pengetahuan sebesar 40 % yang berkriteria baik dn sangat baik. Pencapaian tertinggi yaitu pada indicator menghitung pH larutan asam-basa dan pencapaian terendah pada indicator menghitung konsentrasi [H+] dan [OH-] dalam larutan. Tanggapan positif diberikan oleh siswa dengan project based learning yang telah diterapkan.
PENGARUH SCIENCE ADAPTIVE ASSESSMENT TOOL BERBASIS GAYA BELAJAR KOLB TERHADAP KETERAMPILAN BERPIKIR TINGKAT TINGGI
Authors: Zulfiani Zulfiani , Suwarna Iwan Permana 
Published: March 2020

THE EFFECT OF SCIENCE ADAPTIVE ASSESSMENT TOOL BASED ON KOLB LEARNING STYLE ON HIGH-LEVEL THINKING SKILLSAbstractThis study aimed to determine the effect of the Science Adaptive Assessment Tool (SAA Tool) based on the KOLB learning style on student's high order thinking skills (HOTS). This study used a quantitative quasi-experiment method with a post-test only design. The subjects in this study were 79 students of 8th grade at SMP Al- Zahra Indonesia Tangerang Selatan in the 2018/2019 school year who studied the material of Living organisms and Simple Machine. The results showed that there was a significant difference between the student's higher-order thinking skills who used Biology and Physics's SAA Tool compared with the control class. Biology's SAA Tool influences the results of higher-order thinking skills towards four learning styles. They affect of diverger, assimilator, converger, and accommodator. The Physics's SAA Tool influences the results of higher-order thinking skills on two learning styles of diverger and accommodator. The results of this study indicate the potential application of the SAA Tool as an answer to the problems of digital assessment to measure higher-order thinking skills as one of the dominant thinking skills of the 21st-century skills. Keywords: Science Adaptive Assessment Tool (SAA Tool); Integrated Science; High Order Thinking Skill (HOTS)AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh Science Adaptive Assessment Tool (SAA Tool) berbasis gaya belajar KOLB terhadap keterampilan berpikir tingkat tinggi peserta didik. Metode penelitian yang digunakan yaitu metode kuantitatif kuasi eksperimen dengan desain post test only. Subyek penelitian ini adalah 79 peserta didik kelas 8 SMP Al-Zahra Indonesia Tangerang Selatan tahun pelajaran 2019/2020 yang mempelajari materi Sistem Gerak Makhluk Hidup dan Pesawat Sederhana. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara hasil keterampilan berpikir tingkat tinggi peserta didik yang menggunakan SAA Tool IPA Biologi maupun IPA Fisika dibandingkan kelas kontrol. SAA Tool IPA Biologi mempengaruhi hasil keterampilan berpikir tingkat tinggi terhadap 4 gaya belajar diverger, asimilator, konverger, dan akomodator. Sementara SAA Tool IPA Fisika mempengaruhi hasil keterampilan berpikir tingkat tinggi terhadap 2 gaya belajar diverger dan akomodator. Hasil penelitian ini menunjukkan potensi aplikasi SAA Tool sebagai jawaban problematika asesmen digital untuk mengukur keterampilan berpikir tingkat tinggi sebagai salah satu skill berpikir dominan keterampilan abad 21.Kata Kunci: Science Adaptive Assessment Tool (SAA Tool); IPA Terpadu; Keterampilan Berpikir Tingkat Tinggi (HOTS)
Ewa Mazierska, <i>Popular Viennese Electronic Music, 1990–2015</i>
Authors: Bottà Giacomo 
Published: March 2020

Ewa Mazierska, Popular Viennese Electronic Music, 1990–2015. London and New
York: Routledge, 2019. 239 pp. ISBN 978-1-138-71391-8 (hbk).
"Let us imagine...": Wittgenstein's Invitation to Philosophy
Authors: Savickey Beth 
Published: March 2020

Wendy Lee-Lampshire writes that Wittgenstein’s conception of language has something valuable to offer feminist attempts to construct epistemologies firmly rooted in the social, psychological and physical situations of language users (1999: 409). However, she also argues that his own use of language exemplifies a form of life whose constitutive relationships are enmeshed in forms of power and authority. For example, she interprets the language game of the builders as one of slavery, and questions how we read and respond to it. She asks: “Who are ‘we’ as Wittgenstein’s reader(s)?” This is an important question, and how we answer offers insight not only into our own philosophical practices, but also into Wittgenstein’s use of language games. With the words “Let us imagine...”, Wittgenstein invites readers to participate in creative, collaborative, and improvisational language games that alter not only the texts themselves, but our relationship with others.
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease
Authors: Guan Yuting , Liu Hongbo , Ma Ziyuan , Li Szu-Yuan , Park Jihwan , Sheng Xin , Susztak Katalin 
Published: March 2020

Significance Statement
Cytosine methylation plays a key role in determining cell fate and response to stimuli. Using mice with kidney-specific deletion of genes encoding de novo DNA methyltransferases Dnmt3a and Dnmt3b, the authors showed that these genes are responsible for methylation of gene regulatory regions that act as enhancers during kidney development but are then decommissioned in adult mice. Although the knock-out mice displayed no obvious kidney abnormalities at baseline, they showed resistance to induced AKI. The authors also discovered that human kidney disease risk loci were enriched on fetal regulatory regions (enhancers) that were decommissioned by Dnmt3a/3b and no longer active in the adult kidney. These findings suggest that adult kidney diseases could have a developmental origin and that genetic and epigenetic (such as Dnmt3a/3b) factors could converge on the same genetic regions resulting in kidney disease development.

Background
Cytosine methylation is an epigenetic mark that dictates cell fate and response to stimuli. The timing and establishment of methylation logic during kidney development remains unknown. DNA methyltransferase 3a and 3b are the enzymes capable of establishing de novo methylation.

Methods
We generated mice with genetic deletion of Dnmt3a and Dnmt3b in nephron progenitor cells (Six2

Cre

Dnmt3a/3b) and kidney tubule cells (Ksp

Cre

Dnmt3a/3b). We characterized Ksp

Cre

Dnmt3a/3b mice at baseline and after injury. Unbiased omics profiling, such as whole genome bisulfite sequencing, reduced representation bisulfite sequencing and RNA sequencing were performed on whole-kidney samples and isolated renal tubule cells.

Results

Ksp

Cre

Dnmt3a/3b mice showed no obvious morphologic and functional alterations at baseline. Knockout animals exhibited increased resistance to cisplatin-induced kidney injury, but not to folic acid–induced fibrosis. Whole-genome bisulfite sequencing indicated that Dnmt3a and Dnmt3b play an important role in methylation of gene regulatory regions that act as fetal-specific enhancers in the developing kidney but are decommissioned in the mature kidney. Loss of Dnmt3a and Dnmt3b resulted in failure to silence developmental genes. We also found that fetal-enhancer regions methylated by Dnmt3a and Dnmt3b were enriched for kidney disease genetic risk loci. Methylation patterns of kidneys from patients with CKD showed defects similar to those in mice with Dnmt3a and Dnmt3b deletion.

Conclusions
Our results indicate a potential locus-specific convergence of genetic, epigenetic, and developmental elements in kidney disease development.