bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Syndrome With Short Stature, Mandibular Hypoplasia, and Osteoporosis May Be Associated With a PRRT3 Variant
Authors: Garg Abhimanyu , El-Shanti Hatem , Xing Chao , Zhou Zhengyang , Abujbara Mousa , Al-Rashed Khadeja , El-Khateeb Mohammed , Ajlouni Kamel , Agarwal Anil K 
Published: July 2020

Abstract

Context
Despite considerable progress in elucidating the molecular basis of various progeroid syndromes, some rare patients remain unexplained.

Objective
To elucidate molecular genetic basis of a novel autosomal recessive progeroid syndrome.

Participants
A 24-year-old male and his 18-year-old sister with short stature, mandibular hypoplasia, pointed nose, shrill voice, severe osteoporosis, and short eyebrows and their unaffected siblings and parents belonging to a consanguineous Arab family.

Results
Using exome and Sanger sequencing, we report a novel homozygous p.Glu394Lys disease-causing variant in proline-rich transmembrane protein 3 (PRRT3). PRRT3 belongs to the family of proline-rich proteins containing several repeats of a short proline-rich sequence, but its function remains to be determined. Preliminary observations showing colocalization of Prrt3 and synaptophysin support its role in vesicle exocytosis. Consistent with the highest messenger ribonucleic acid expression of PRRT3 in the pituitary, both the patients had mild growth hormone deficiency but had near normal reproductive development.

Conclusions
We conclude that the homozygous p.Glu394Lys variant in PRRT3 may be associated with a novel autosomal recessive, progeroid syndrome with short stature, mandibular hypoplasia, osteoporosis, short eyebrows, and mild growth hormone (GH) deficiency. Our findings extend the spectrum of progeroid syndromes and elucidate important functions of PRRT3 in human biology, including secretion of GH from the pituitary.
Linking death registration and survey data: Procedures and cohort profile for The Irish Longitudinal Study on Ageing
Authors: Ward Mark , May Peter , Briggs Robert , McNicholas Triona , Normand Charles , Kenny Rose Anne , Nolan Anne 
Published: July 2020

Background: Research on mortality at the population level has been severely restricted by an absence of linked death registration and survey data in Ireland. We describe the steps taken to link death registration information with survey data from a nationally representative prospective study of community-dwelling older adults. We also provide a profile of decedents among this cohort and compare mortality rates to population-level mortality data. Finally, we compare the utility of analysing underlying versus contributory causes of death. Methods: Death records were obtained for 779 (90.3% of all confirmed deaths at that time) and linked to individual level survey data from The Irish Longitudinal Study on Ageing (TILDA). Results: Overall, 9.1% of participants died during the nine-year follow-up period and the average age at death was 75.3 years. Neoplasms were identified as the underlying cause of death for 37.0%; 32.9% of deaths were attributable to diseases of the circulatory system; 14.4% due to diseases of the respiratory system; while the remaining 15.8% of deaths occurred due to all other causes. Mortality rates among younger TILDA participants closely aligned with those observed in the population but TILDA mortality rates were slightly lower in the older age groups. Contributory cause of death provides similar estimates as underlying cause when we examined the association between smoking and all-cause and cause-specific mortality. Conclusions: This new data infrastructure provides many opportunities to contribute to our understanding of the social, behavioural, economic, and health antecedents to mortality and to inform public policies aimed at addressing inequalities in mortality and end-of-life care.
Parameters of resilience of employees of internal affairs bodies sent to serve in the North Caucasus region
Authors: Vasil'eva Inna , Vozzhenikova Ol'ga 
Published: July 2020

he main areas of research into the consequences of extreme situations associated with the participation of police officers in counter-terrorism operations are related to assessing the severity of posttraumatic stress disorder and other destructive effects on the psyche. In the framework of this study, the authors show that the experience of participation in extreme situations can have productive effects associated with increased vitality.
The study involved employees of the Ministry of Internal Affairs of Russia, 21 people (all men) undergoing training to participate in counter-terrorism operations in the North Caucasus region of the Russian Federation. Data collection methods: Mississippi scale for assessing post-traumatic reactions (military option); test of viability S. Muddy (in adaptation D.A. Leontiev, E.I. Rasskazova).
The experience of participating in hostilities, the activity of an internal affairs officer is highly stressful and traumatic, associated with the need to overcome aggressive pressure and provide assistance in situations of suffering and helplessness, which is also a traumatic factor. However, none of the participants were diagnosed with post-traumatic stress disorder. The following pattern was established: the younger the employee and the less experience he has, the less pronounced his violations associated with being in extreme conditions. Employees with experience in counterterrorism operations perceive risk situations not as destructive, but as natural for the implementation of professional tasks.
The greatest contribution to adaptation strategies to cope with the consequences of experiencing traumatic situations is made by such viable beliefs as willingness to perceive any situation as useful and risking for the sake of achieving a better result, as well as the belief that any difficulties can be overcome and the employee’s efforts are enough to deal with them. It is these characteristics that make the maximum contribution to the stability of employees of internal affairs bodies to the effects of psychotraumatic factors and ensure a high level of their resilience.
Decolonialidade e estudos críticos do discurso: convergências para abordagens antirracistas no Brasil
Authors: Da Silva Caroline Fernanda Santos 
Published: July 2020

Este trabalho tem como objetivo compreender, analisar e problematizar a forma como os estudos críticos do discurso (ECD) e a perspectiva da decolonialidade podem convergir para uma abordagem antirracista no Brasil. Para isso, o texto está dividido em dois subitens, além da introdução e das considerações finais, que apresentam os conceitos em destaque e problematizam alguns elementos importantes com relação aos mesmos. No primeiro item, apresenta-se uma breve reflexão sobre os fundamentos da produção de conhecimentos, apontando importantes contribuições e questionamentos de autores que abordam a perspectiva decolonial. Na sequência, o texto apresenta uma breve introdução aos estudos críticos do discurso (ECD), situando a relevância de sua utilização para a compreensão, abordagem e análise do racismo no Brasil. Palavras-Chave: estudos críticos do discurso; decolonialidade; antirracismo.
Aborto, Racismo e Violência: Reflexões a partir do Feminismo Negro
Authors: Lima Nathália Diórgenes Ferreira , Cordeiro Rosineide De Lourdes Meira 
Published: July 2020

A criminalização do aborto no Brasil não reduz os números de abortamento, mas expõe a saúde e a vida reprodutiva das mulheres. As experiências das mulheres em situação de abortamento são diversas e permeadas pelas estruturas de classe e raça. O presente artigo tem como objetivo analisar como o racismo e a violência se materializam na vida de jovens de periferia conformando situações de aborto atravessadas por violência. Para tal abordaremos histórias de duas jovens negras e periféricas que recorreram ao aborto ilegal. Nossa lente teórica é o feminismo negro, pois nos permite desnaturalizar a concepção universal de mulher e compreender o racismo como estruturante na vida das mulheres. Os resultados apontam que há um cenário complexo de violência racial de gênero que não apenas atua em todo o processo de aborto, mas se traduz em um projeto de opressão fundante da vida reprodutiva das mulheres negras.Palavras-chave: racismo; aborto; violência racial de gênero.
A Review of COVID-19 and the Implications for Orthodontic Provision in England
Authors: Zahran Sally , Wright Natasha 
Published: July 2020

COVID-19 is an unprecedented virus that is destroying the lives of many people worldwide. Dentistry as a profession falls into a high-risk group due to our close proximity to patients and the aerosols generated in routine dental procedures. The UK dental community has frantically searched for answers to questions about the new virus and guidance on provision of dental care. This article will review the most up-to-date recommendations for infection control procedures and use of personal protective equipment (PPE) in England. PubMed, Embase and Google Scholar databases were searched up until 9 June. This is a review of the current information, guidelines and recommendations about the COVID-19 virus and use of PPE for dentists and orthodontists. As of 9 June, the dental profession has received mixed guidance on how best to manage our patients whilst national lockdown is eased and we enter a recovery phase, but uncertainty remains for the long-term provision of Orthodontics. CPD/Clinical Relevance: This article gives an overview of guidance and recommendations for dentists and orthodontists in the UK during the COVID-19 pandemic, especially with regards to infection control and use of PPE.
Combined Hemimandibular Hyperplasia and Elongation: the Orthodontic-Surgical Management
Authors: Devine Ciarán , Sayan Anna , Ilankovan Velupillai 
Published: July 2020

Patients commonly present to orthodontists with complaints of facial and/or mandibular asymmetry. It is important that all asymmetry complaints are taken seriously and further investigated. Orthodontists play an important role in the diagnosis, management and follow-up of these conditions. For condylar hyperactivity, management is generally in a multidisciplinary setting. Clinicians who practice orthodontics in a primary care setting need to be aware of the correct terminology and the appropriate investigations required for diagnosis and the management of this condition. This paper aims to describe the contemporary management of condylar hyperactivity and presents a case of combined orthodontic-surgical treatment. CPD/Clinical Relevance: Condylar hyperactivity can lead to severe orofacial deformities and severe malocclusions. The orthodontist must understand the terminology, diagnostic techniques and treatment of this condition in order to offer the most appropriate management. The entire dental team may be involved in cases of condylar hyperactivity from diagnosis through to follow-up. Increased awareness may therefore improve diagnosis and ensure appropriate early referrals are made, thus potentially improving outcomes.
<p><strong>Moss inhabiting flea beetles of the West Indies IV: new species of <em>Andersonaltica </em>Linzmeier and Konstantinov from the Dominican Republic (Coleoptera: Chrysomelidae: Galerucinae: Alticini)</strong></p>
Authors: KONSTANTINOV ALEXANDER S. , LINZMEIER ADELITA M. , SCHEFFER SONJA J. , LEWIS MATTHEW L. 
Published: July 2020

Two new species of bryobiont flea beetles (Coleoptera: Chrysomelidae: Galerucinae: Alticini) from Dominican Republic are described and illustrated: Andersonaltica neiba sp. nov. (Sierra de Neiba) and A. villabarrancoli sp. nov. (Sierra de Baoruco). New species are compared morphologically with each other. Unusual intraspecific variability of A. villabarrancoli is reported. To obtain additional data in understanding the similarities between the specimens of A. villabarrancoli, we sequenced the Cytochrome oxidase I barcode region of adults and larvae. In all cases, the sequences are identical suggesting that the specimens in questions are conspecific. Key words: Bryobionts, COI barcodes, flea beetles, Monoplatina, moss cushions, species boundaries
MHz-repetition rate fs-laser-inscribed crystalline waveguide lasers inscribed at 100 mm/s: erratum
Authors: Hasse Kore , Kränkel Christian 
Published: July 2020

We present an erratum concerning the repetition rate of the fs-laser system used for the inscription of the waveguides stated in our paper [Opt. Express 28, 12011 (2020)10.1364/OE.381443]. The Fidelity HP High Energy laser supplied by Coherent Inc. features a repetition rate of 10 MHz instead of the value of 1 MHz stated in the paper.
PAM-4 transmission up to 160  Gb/s with surface-normal electro-absorption modulators
Authors: Iannone Patrick , Chen Xi , Grillanda Stefano , Raybon Gregory , Burrows Ellsworth , Adamiecki Andrew , Hu Ting-Chen , Neilson David T. , Basavanhally Nagesh , Low Yee , Kopf Rose , Tate Alaric , Earnshaw Mark 
Published: July 2020

We report multi-level modulation in polarization-independent surface-normal electro-absorption modulators (SNEAMs). Four-level pulse amplitude modulation (PAM-4) at a line rate of 44 Gb/s is demonstrated on a fully packaged SNEAM with a 30 µm active area diameter and a 14 GHz electro-optic bandwidth. High-capacity PAM-4 transmission at 112 and 160 Gb/s is demonstrated on an unpackaged SNEAM chip, with a 15 µm active area diameter and ultrawide electro-optic bandwidth (

≫

65

G
H
z

). Fiber transmission is investigated for direct detection link lengths up to 23 km at 44 Gb/s and 2 km at 112 and 160 Gb/s, the highest multi-level modulation rates achieved on a SNEAM.
Analysis of adhesive bond strength under simulated pulpal pressure on different dentin thicknesses
Authors: Haddad Bruno Amaral , Silva Tânia Mara , Gonçalves Lucélia Lemes , Silva Mateus Rodrigues , Moreira Junior Cláudio , Santis Leandro Ruivo , Gonçalves Sérgio Eduardo de Paiva 
Published: July 2020

Objective: Evaluate the microtensile bond strength (µTBS) in different dentin thicknesses, under simulated pulpal pressure (SPP), submitted to an adhesive technique using laser irradiation. Material and methods: Forty sound human molars were sectioned and randomly divided into two groups (n=20): Group 1 – 1 mm of dentin thickness; Group 2 – 2 mm of dentin thickness. Each group was divided into two subgroups (n=10): Subgroup A – Absence of SPP; Subgroup P – Presence of SPP (15 cm H2O). The samples were sequentially treated with: 37% phosphoric acid, adhesive system (Adper Single Bond 2), Nd:YAG laser irradiation (60 s, 1064 nm, 10 Hz) using 60 and 100 mJ/pulse energy parameters and photopolymerization (10 s). A composite resin block (Filtek Z350) was built up onto the irradiated area. After 30 days stored in water, the samples were sectioned and submitted to microtensile test (10 kgf load cell, 0.5mm/min). Data were analyzed by three-way ANOVA and Tukey tests. Results: Three-way ANOVA revealed no significant differences for SPP (p=0.0821) and for dentin thickness p= 0.9405) on bond strength. The laser energy parameters (p=0.001) indicated that 100 mJ showed greater µTBS means compared to the group irradiated with 60 mJ. Dentin thickness did not affect on µTBS. The presence of SPP reduced the mean µTBS values. Conclusions: Simulated pulpal pressure did not affect the µTBS using 60 mJ of laser energy parameter. At 100 mJ, the presence of SPP negatively influenced the bond strength, regardless of dentin thickness. KEYWORDSBond strength; Dentin; Intrapulpal pressure; Nd:YAG laser.
Role of the Outer Inflammatory Protein A/Cystine–Glutamate Transporter Pathway in Gastric Mucosal Injury Induced by Helicobacter pylori
Authors: Du Jie , Li Xiao-Hui , Liu Fen , Li Wen-Qun , Gong Zhi-Cheng , Li Yuan-Jian 
Published: July 2020

INTRODUCTION:

Helicobacter pylori infection is a major cause of gastrointestinal diseases. However, the pathogenesis of gastric mucosal injury by H. pylori remains unclear. Exogenous glutamate supplementation protects against gastric mucosal injury caused by H. pylori. Previously, we showed that aspirin-induced gastric injury is associated with reduction in glutamate release by inhibition of cystine–glutamate transporter (xCT) activity. We hypothesized that the xCT pathway is involved in H. pylori-induced gastric mucosal injury. In this study, we tested the activity of xCT and evaluated the regulatory effect of outer inflammatory protein (Oip) A on xCT in H. pylori-induced gastric mucosal injury.

METHODS:
In the H. pylori-infected mice and cell lines, the activity of xCT and the regulatory effect of microRNA on xCT were tested, and the effect of OipA from H. pylori on xCT activity was observed.

RESULTS:
The results of in vivo and in vitro experiments showed that H. pylori infection induced gastric mucosal injury. This was accompanied by a reduction in xCT activity, which was attenuated by exogenous glutamate treatment. Furthermore, the expression of miR-30b was upregulated, and miR-30b inhibitors significantly restored xCT activity and gastric mucosal injury caused by H. pylori infection. The OipA, a virulence protein from H. pylori, significantly upregulated the expression levels of miR-30b and inhibited xCT activity.

DISCUSSION:
OipA plays a significant role in H. pylori-induced gastric mucosal injury, and the effects are mediated by micro30b/xCT pathway.
Pemanfaatan Aplikasi Google Form dalam Meningkatkan Pelaksanaan Supervisi Pendidikan Pengawas Madrasah
Authors: Rahmiyati Sri 
Published: July 2020

Utilization of the Google Form application is done as an alternative action when the supervisor of Madrasah encountered several obstacles in the field relating to the area and the number of building Madrasah. The ease of the Google Form application for daily activities is: 1) real-time distribution and tabulation; 2) Real time collaboration; 3) secure; Storing important files or school assignments is not afraid of lost or damaged or exposed to viruses. Google Form is also an easy-to-use application even for beginners, free (free to pay), usually the data results are presented in an Excel file so it is easy to use and a fairly lightweight program. Utilization of the Google Form application in assisting the oversight of the madrasah to be effective and efficient can be described as follows; 1) Facilitate the supervisors to collect data without having to meet the speakers directly, especially for speakers who are away from the location of supervision activities; 2) for the necessary data of the activity or administration report that does not require the presence of a supervisor in the field, then data retrieval through instruments created by Google Form will assist the implementation of the supervisory duties more effective and efficient madrasah. 3) Availability of features available in Google Form such as charts, tables, Excel and others, greatly supports the data needs of the madrasah supervisor.
Development of Tourism in Uzbekistan and Cultural-Historical Tourist Resource Potential of Kashkadarya Region
Authors: NAZAROV Mamatkodir I. , JUMAEV Hayrulla H. , TURDIMAMBETOV Izimbet R. , YANCHUK Sergey L. , EGAMBERDIEVA Matluba M. 
Published: July 2020

Abstract:
In the modern world economic development, the tertiary sector plays an important role in the life of different countries. Tourist-reaction services are gaining importance in this regard. The main goal of this study was to analyze the potential of the cultural and historical tourism resource of the Kashkadarya region and to identify its regional features. Conditions of tourism formation in Uzbekistan have been analyzed. Attention was paid to existing recreational potential and the effectiveness of its use. The specificity of the classification of tourism recreational resources based on the research of scientists has been clarified. The potential of the Kashkadarya region tourist recreational resources, which plays a special role by its resource potential in the development of tourism in Uzbekistan, has been analyzed as an example of monuments of material and cultural heritage, at the scale of urban and rural areas. It was found that the Kashkadarya region has immense potential due to cultural heritage and natural recreational potential.
Crystal structure of poly[bis{μ2-5-carboxy-4′-methyl-[1,1′-biphenyl]-3-carboxylato-κ2
O:O′}-{μ2-4,4′-bipyridine-κ2N:N′}]cobalt(II), C40H30N2O8Co
Authors: Hu Shao-Qiang , Li Shi-Hui 
Published: July 2020

Abstract
C40H30N2O8Co, triclinic, P1̄ (no. 2), a = 9.8766(6) Å, b = 11.5473(8) Å, c = 14.2194(9) Å, α = 84.534(5)°, β = 85.582(5)°, γ = 79.413(5)°, V = 1583.90(17) Å3, Z = 2, R
gt(F) = 0.0650, wR
ref(F
2) = 0.1109, T = 293(2) K.
Analysis of Metakaolin as Partial Substitution of Ordinary Portland Cement in Reactive Powder Concrete
Authors: Abellán-García Joaquín , Santofimio-Vargas María Alejandra , Torres-Castellanos Nancy 
Published: July 2020

Abstract
Over the last 20 years, remarkable advances have taken place in the research on reactive powder concrete (RPC). However, because of the high contents of cement and silica fume (SF) usually used in those types of concrete, the cost and environmental impact of RPC is considerably higher than conventional concrete. Hence, the use of supplementary cementitious materials as partial substitution of cement and SF has been an object of great interest by the scientific community. However, the replacement of cement and SF can result in the deterioration of certain properties of RPC, such as the early strength; however, RPC usually needs great amounts of cement and SF. This work presents a study to analyze the effect of metakaolin (MK) as a partial substitute of cement in a previously optimized mixture of RPC using statistical tools such central composite design, main effect plot analysis, and response surface methodology. In addition to MK, supplementary cementitious materials such as SF, limestone powder and recycled glass powder, and fine Type III cement were used. Based on the laboratory experiments results and statistical analysis, it was concluded than MK develops a high activity in the hydration process of RPC, helping it reach high strength at early ages, such as 1 and 7 days, which may be of interest for applications such as the connection of prefabricated elements or accelerated bridge construction. However, the effect of the partial substitution of Type III cement by MK on 28-day compressive strength was nonsignificant. Moreover, the MK inclusion in RPC provides a significant decrease in workability as the amount of MK increases.
Introdução À Genética Forense
Authors: Silva Juciara da Costa 
Published: July 2020

“Introdução à Genética Forense” é uma bibliografia organizada através do empenho de 5 profissionais da perícia científica. A obra dispõe da colaboração de 27 autores gabaritos nas mais distintas áreas entre elas: ciências biológicas, ciências biomédicas, odontologia e ciências farmacêuticas. O linear de intersecção entre eles é a ampla experiência nas distintas esferas da genética forense.