bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Patterns of Relationships Between Geographic Markers and IBD: Possible Intrusion of Obesity
Authors: Szilagyi Andrew , Smith Brian E , Sebbag Natanel , Leighton Henry , Xue Xiaoqing 
Published: May 2020

AbstractBackgroundLatitude and lactase digestion status influence incidence and prevalence rates of some noncommunicable diseases. Latitudinal correlations helped define beneficial roles of vitamin D in many diseases like inflammatory bowel disease (IBD). In view of recent global expansion of IBD and population migrations, we reexamine relations with these markers. As these changes also paralleled the pandemic of obesity, we explore possible interactions with IBD.MethodsWe undertook a literature review to compare rates of obesity, Crohn’s disease and ulcerative colitis with the geographic markers of lactase digestion status, average population-weighted national latitude, and national yearly sunshine exposure. Pearson correlations were used throughout to determine r correlation factors. Statistical significance was accepted at P &lt;0.05 using 2-tailed tests.ResultsForty-seven countries were matched with various data sets that could be analyzed (range of availability was 49%–85%). While global correlations of IBD with latitude and lactase status remain similar to previous analyses, in Europe and Asia, outcomes were different. Global outcome contains a statistical paradox related to combining countries from Europe and Asia. Obesity showed moderate global correlations with IBD but weak and negligible correlations in Europe and Asia. There was also a weak global correlation with latitude.ConclusionsIt is suggested that global correlations point to parallel geographic spread of IBD and obesity. The lack of latitudinal relations with obesity suggests reduced vitamin D effect. The paradox supports epidemiological differences in western and eastern IBD. Obesity combined with IBD may contribute to different relations, partly due to variable vitamin D effects.
Congenital double mitral orifice with severe mitral regurgitation-associated rheumatoid arthritis: a case report
Authors: Natraj Setty Huliurdurga Srinivasa Setty , Shankar Somanna , Yeriswamy Mogalahally Channabasappa , Manjunath Cholenahally Nanjappa 
Published: May 2020

Abstract

Background
A double orifice mitral valve (DOMV) represents a rare congenital malformation characterized by two valve orifices with two separate subvalvular apparatus. Double orifice mitral valve is congenital anomaly of the subvalvular mitral valve apparatus consisting of an accessory bridge of fibrous tissue, which partially or completely divides the mitral valve into two orifices.

Case summary
A 30-year young male presented with dyspnoea and palpitation for 4 years, joint pain for 2 years and weakness of right upper limb and lower limb for 6 months. On clinical examination, Boutonniere, Swan neck, and Z-deformity of hand and foot metatarsal bone deformities are noted, on further evaluation, patient was diagnosed as a case of DOMV and was managed conservatively since patient was not willing for surgery.

Discussion
Two-dimensional echocardiography is the best detection method, the parasternal short-axis view being most useful to show DOMV.
Schools as centers for health educational initiatives, health behavior research and risk behavior for dengue infection in school children and community members: a systematic review
Authors: Díaz-González Esteban E , Danis-Lozano Rogelio , Peñaloza Gonzalo 
Published: May 2020

Abstract
Dengue virus is the main arboviral disease transmitted by Aedes mosquitoes and affects mainly school-aged children and teens. Many methods have been developed for dengue control, including health education strategies for elementary and high school students. The objective of this study is to provide an update on the status of health education on dengue in schools and provide new perspectives on health behavior research in order to reduce the proliferation of mosquitoes and spread of arboviral diseases among school-aged children and other community members. A systematic review about health educational initiatives was carried out. This research discusses the effectiveness of these strategies in educating students about dengue disease and mosquito control and how the school is relevant for community-based participation in research on dengue education. The study found that employing ludic strategies and directly involving children in mosquito control in their households have been the most attractive and effective strategies for dengue education in children and teens. However, the sustainability of protective behaviors has been poorly evaluated, and new approaches for health behavior research are needed. Inasmuch as, schools are important places for gathering community members, and students can serve as an essential link between educative interventions and the community.
Asymptotics for the Expected Number of Nodal Components for Random Lemniscates
Authors: Kabluchko Zakhar , Wigman Igor 
Published: May 2020

AbstractWe determine the true asymptotic behaviour for the expected number of connected components for a model of random lemniscates proposed recently by Lerario and Lundberg. These are defined as the subsets of the Riemann sphere, where the absolute value of certain random, $\textrm{SO}(3)$-invariant rational function of degree $n$ equals to $1$. We show that the expected number of the connected components of these lemniscates, divided by $n$, converges to a positive constant defined in terms of the quotient of two independent plane Gaussian analytic functions. A major obstacle in applying the novel non-local techniques due to Nazarov and Sodin on this problem is the underlying non-Gaussianity, intrinsic to the studied model.
Building antimicrobial stewardship through massive open online courses: a pilot study in Macedonia
Authors: von Schreeb Sebastian , Robilotti Elizabeth , Deresinski Stan , Boshevska Golubinka , Panovski Nikola , Tyrstrup Mia , Hedin Katarina , Milevska-Kostova Neda 
Published: May 2020

Abstract

Background
The global struggle against antibiotic resistance requires antimicrobial stewardship (AMS). Massive open online courses (MOOCs) offer health professionals unprecedented access to high-quality instructional material on AMS; the question is how apprehensible it is to non-native English speakers. Furthermore, to better understand how education interventions promote change towards rational antibiotic prescribing, leading institutions call for studies integrating behavioural science. Research from lower- and middle-income countries is particularly needed.

Objectives
To measure the knowledge improvement from an AMS MOOC, the influence of language, course satisfaction and subsequent effect on intention to change antibiotic prescribing behaviour.

Methods
Fifty-five physicians from Macedonia completed the MOOC. Pre- and post-course knowledge test scores were compared using a one-sample t-test. The effect of a language barrier was assessed using self-reported English level. Scores were compared with participants’ intention to change behaviour in clinical practice.

Results
Scores significantly improved from 77.8% to 82.2%. Participants with a higher English level improved most, while the low-level group showed no significant improvement. Physicians reported a high or very high intention to change behaviour. This was independent of knowledge improvements.

Conclusions
First, lower self-reported English proficiency hindered knowledge acquisition from a MOOC platform. AMS programmes should commit to bridge this barrier so as to enable a global spread of education in AMS. Second, factors underlying the physicians’ intentions to engage in AMS appear to be more complex than simple knowledge improvements. This suggests that less time-consuming interventions could be as effective.
The HD-ZIP IV transcription factor GL2-LIKE regulates male flowering time and fertility in cucumber
Authors: Cai Yanling , Bartholomew Ezra S , Dong Mingming , Zhai Xuling , Yin Shuai , Zhang Yaqi , Feng Zhongxuan , Wu Licai , Liu Wan , Shan Nan , Zhang Xiao , Ren Huazhong , Liu Xingwang 
Published: May 2020

AbstractCucumber is dioecious by nature, having both male and female flowers, and is a model system for unisexual flower development. Knowledge related to male flowering is limited, but it is reported to be regulated by transcription factors and hormone signals. Here, we report functional characterization of the cucumber (Cucumis sativus) GL2-LIKE gene, which encodes a homeodomain leucine zipper (HD-ZIP) IV transcription factor that plays an important role in regulating male flower development. Spatial–temporal expression analyses revealed high-level expression of CsGL2-LIKE in the male flower buds and anthers. CsGL2-LIKE is closely related to AtGL2, which is known to play a key role in trichome development. However, ectopic expression of CsGL2-LIKE in Arabidopsis gl2-8 mutant was unable to rescue the gl2-8 phenotype. Interestingly, the silencing of CsGL2-LIKE delayed male flowering by inhibiting the expression of the florigen gene FT and reduced pollen vigor and seed viability. Protein–protein interaction assays showed that CsGL2-LIKE interacts with the jasmonate ZIM domain protein CsJAZ1 to form a HD-ZIP IV–CsJAZ1 complex. Collectively, our study indicates that CsGL2-LIKE regulates male flowering in cucumber, and reveals a novel function of a HD-ZIP IV transcription factor in regulating male flower development of cucumber.
The amino acid transporter AAP1 mediates growth and grain yield by regulating neutral amino acid uptake and reallocation in Oryza sativa
Authors: Ji Yuanyuan , Huang Weiting , Wu Bowen , Fang Zhongming , Wang Xuelu 
Published: May 2020

Abstract
Nitrogen (N) is a major element necessary for crop yield. In most plants, organic N is primarily transported in the form of amino acids. Here, we show that amino acid permease 1 (AAP1) functions as a positive regulator of growth and grain yield in rice. We found that the OsAAP1 gene is highly expressed in rice axillary buds, leaves, and young panicles, and that the OsAAP1 protein is localized to both the plasma membrane and the nuclear membrane. Compared with the wild-type ZH11, OsAAP1 overexpression (OE) lines exhibited increased filled grain numbers as a result of enhanced tillering, while RNAi and CRISPR (clustered regularly interspaced short palindromic repeat; Osaap1) knockout lines showed the opposite phenotype. In addition, OsAAP1-OE lines had higher concentrations of neutral and acidic amino acids, but lower concentrations of basic amino acids in the straw. An exogenous treatment with neutral amino acids promoted axillary bud outgrowth more strongly in the OE lines than in the WT, RNAi, or Osaap1 lines. Transcriptome analysis of Osaap1 further demonstrated that OsAAP1 may affect N transport and metabolism, and auxin, cytokinin, and strigolactone signaling in regulating rice tillering. Taken together, these results support that increasing neutral amino acid uptake and reallocation via OsAAP1 could improve growth and grain yield in rice.
piNET: a versatile web platform for downstream analysis and visualization of proteomics data
Authors: Shamsaei Behrouz , Chojnacki Szymon , Pilarczyk Marcin , Najafabadi Mehdi , Niu Wen , Chen Chuming , Ross Karen , Matlock Andrea , Muhlich Jeremy , Chutipongtanate Somchai , Zheng Jie , Turner John , Vidović Dušica , Jaffe Jake , MacCoss Michael , Wu Cathy , Pillai Ajay , Ma’ayan Avi , Schürer Stephan , Kouril Michal , Medvedovic Mario , Meller Jarek 
Published: May 2020

Abstract
Rapid progress in proteomics and large-scale profiling of biological systems at the protein level necessitates the continued development of efficient computational tools for the analysis and interpretation of proteomics data. Here, we present the piNET server that facilitates integrated annotation, analysis and visualization of quantitative proteomics data, with emphasis on PTM networks and integration with the LINCS library of chemical and genetic perturbation signatures in order to provide further mechanistic and functional insights. The primary input for the server consists of a set of peptides or proteins, optionally with PTM sites, and their corresponding abundance values. Several interconnected workflows can be used to generate: (i) interactive graphs and tables providing comprehensive annotation and mapping between peptides and proteins with PTM sites; (ii) high resolution and interactive visualization for enzyme-substrate networks, including kinases and their phospho-peptide targets; (iii) mapping and visualization of LINCS signature connectivity for chemical inhibitors or genetic knockdown of enzymes upstream of their target PTM sites. piNET has been built using a modular Spring-Boot JAVA platform as a fast, versatile and easy to use tool. The Apache Lucene indexing is used for fast mapping of peptides into UniProt entries for the human, mouse and other commonly used model organism proteomes. PTM-centric network analyses combine PhosphoSitePlus, iPTMnet and SIGNOR databases of validated enzyme-substrate relationships, for kinase networks augmented by DeepPhos predictions and sequence-based mapping of PhosphoSitePlus consensus motifs. Concordant LINCS signatures are mapped using iLINCS. For each workflow, a RESTful API counterpart can be used to generate the results programmatically in the json format. The server is available at http://pinet-server.org, and it is free and open to all users without login requirement.
LocalSTAR3D: a local stack-based RNA 3D structural alignment tool
Authors: Chen Xiaoli , Khan Nabila Shahnaz , Zhang Shaojie 
Published: May 2020

Abstract
A fast-growing number of non-coding RNA structures have been resolved and deposited in Protein Data Bank (PDB). In contrast to the wide range of global alignment and motif search tools, there is still a lack of local alignment tools. Among all the global alignment tools for RNA 3D structures, STAR3D has become a valuable tool for its unprecedented speed and accuracy. STAR3D compares the 3D structures of RNA molecules using consecutive base-pairs (stacks) as anchors and generates an optimal global alignment. In this article, we developed a local RNA 3D structural alignment tool, named LocalSTAR3D, which was extended from STAR3D and designed to report multiple local alignments between two RNAs. The benchmarking results show that LocalSTAR3D has better accuracy and coverage than other local alignment tools. Furthermore, the utility of this tool has been demonstrated by rediscovering kink-turn motif instances, conserved domains in group II intron RNAs, and the tRNA mimicry of IRES RNAs.
Heinrich Ignaz Franz Biber
Authors: Brewer Charles E. 
Published: May 2020

During his lifetime, Heinrich Ignaz Franz Biber von Bibern (b. 1644–d. 1704) was widely recognized as one of the foremost performers on the violin, and his published instrumental music helped spread his reputation, though he was criticized by some of his contemporaries for his extravagant technique and use of scordatura. Charles Burney’s comment in his 1789 General History of Music that “of all the violin players of the last century, Biber seems to have been the best, and his solos are the most difficult and most fanciful of any Music I have seen of the same period” was most likely based only on a visual examination of the original print of Biber’s 1681 violin sonatas. Aside from a few specialized studies by Guido Adler, Paul Nettl, and others, and four acknowledged works published in the Denkmäler der Tonkunst in Österreich (two collections of music for solo violin, a mass, and a Requiem), Biber’s music was little known until the 1940s. Modern editions of the other instrumental and sacred music, both published and in manuscript, along with critical studies of both his sacred and secular compositions have significantly enhanced the appreciation of Biber’s compositional creativity. Performances of Biber’s music have also steadily increased along with the “Historically Informed Performance” movement. Since Susanne Lautenbacher’s recording of the “Mystery” Sonatas was released in 1962, there have been a further thirty-four recordings and many of Biber’s other instrumental collections now have multiple recordings available, and even the Missa Salisburgensis has been released on six recordings and two DVDs.
Genicular Nerve Radiofrequency Ablation for Chronic Knee Pain Using a Three-Tined Electrode: A Technical Description and Case Series
Authors: Koshi Edvin , Cheney Cole W , Sperry Beau P , Conger Aaron , McCormick Zachary L 
Published: May 2020

Abstract

Background
Genicular nerve radiofrequency ablation (RFA) for the treatment of chronic knee pain has traditionally targeted the superomedial, superolateral, and inferomedial genicular nerves. However, recent cadaveric studies of knee neuroanatomy demonstrate varied locations of these specific nerves as well as additional articular nerves. This work suggests that traditional genicular nerve RFA lesion locations may be inadequate.

Objective
1) To describe a novel protocol utilizing a three-tined RFA electrode to target the superomedial (SMGN), superolateral (SLGN), and inferomedial genicular nerves (IMGN), as well as the terminal articular branches of the nerves to the vastus medialis (NVM), intermedius (NVI), and lateralis (NVL). 2) To assess the ability of this technique to reduce chronic knee pain.

Methods
Case series of consecutive patients with six or more months of refractory knee pain who underwent genicular nerve RFA according to the novel protocol described. Seven discrete RFA lesions were placed to target the SMGN, NVM, NVI, NVL, SLGN, and IGMN.

Results
Eleven patients underwent RFA, nine with knee osteoarthritis and two postarthroplasty. At one month, 91% (95% CI = 59–100%), 82% (95% CI = 48–98%), and 9% (95% CI = 2–41%), of patients reported ≥50%, ≥80%, and 100% improvement in knee pain on the numeric rating scale, respectively. These results were sustained at six months. There were no complications.

Discussion/Conclusions
These preliminary data suggest the feasibility and possible effectiveness of genicular nerve RFA using the described novel protocol including a three-tined electrode. Larger-scale studies with comparative groups are warranted.
0008 SUVN-G3031, A Histamine H3 Receptor Inverse Agonist Produces Robust Wake Promoting and Anticataplectic Activity in Orexin Knockout Mice
Authors: Benade V , Daripelli S , Petlu S , Subramanian R , Bhyrapuneni G , Shinde A , Rasheed M , Jayarajan P , Choudakari P , Nirogi R 
Published: May 2020

Abstract

Introduction
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, sleep paralysis, hallucinations, and in some cases episodes of cataplexy. Results from animal studies indicate the involvement of deficient orexin transmission in narcolepsy which can be circumvented by the activation of histaminergic neurons. SUVN-G3031 is a potent and selective histamine H3 receptor inverse agonist with hKi of 8.7 nM and shows less than 50% inhibition at 1 µM against 70 other targets. SUVN-G3031 exhibited excellent pharmacokinetic properties and brain penetration in preclinical species. Oral administration of SUVN-G3031 produces significant increase in histamine, dopamine and norepinephrine levels in the rat cortex. Long-term safety studies in animals have been successfully completed without any concern for further development of SUVN-G3031. In the present study, the effects of SUVN-G3031 were evaluated in orexin knockout mice, a reliable animal model of narcolepsy as a proof-of-concept study for the treatment of narcolepsy with and without cataplexy.

Methods
Male orexin knockout mice (10 - 15 weeks old, 25 - 35 g at the time of surgery) were implanted with telemetric device for simultaneous monitoring of electroencephalography (EEG) and electromyography. Animals were allowed surgical recovery of 3 weeks prior to EEG recording. Effects of SUVN-G3031 (3 and 10 mg/kg, p.o.) were evaluated during active period of animals.

Results
SUVN-G3031 produced significant increase in wakefulness with concomitant decrease in non-rapid eye movement sleep in orexin knockout mice. SUVN-G3031 also significantly decreased the number of cataplectic episodes in orexin knockout mice.

Conclusion
Results from the current preclinical study provide a strong basis for the utility of SUVN-G3031 for the treatment of narcolepsy with and without cataplexy. SUVN-G3031 is currently being evaluated in a Phase 2 study as monotherapy for the treatment of narcolepsy with and without cataplexy (ClinicalTrials.gov Identifier: NCT04072380).

Support
None
0011 The Influence of Obstructive Sleep Apnea Severity and Sex on Cerebral Perfusion
Authors: Turner A D , Bubu O M , Rapoport D M , Varga A W , Ayappa I , de Leon M , Rusinek H , Glodzik L , Jean-Louis G , Osorio R 
Published: May 2020

Abstract

Introduction
Obstructive Sleep Apnea (OSA) has been shown to initiate a pathological cascade negatively affecting the cardiovascular system, including cerebral circulation. There is limited data on OSA effects on regional brain function, though reduced global cerebral blood flow (CBF) has been observed among patients with OSA. However, there are few precise assessments. We hypothesized that regional CBF values are altered in OSA, and that sex influences the hypothesized relationship.

Methods
Participants from the NYU Center for Brain Health cohort (n=68; 57.4% female; mean age=66.32±6.84), representing cognitively healthy volunteers with OSA (AHI4% &gt; 5/hr) and without, from several NIA-supported studies, completed evaluations including clinical, structural & functional high-resolution arterial spin labeling 3 tesla MRI scans. Hippocampal and temporal cortex CBF was assessed at baseline and after CO2 challenge using a rebreathing protocol. Analyses were completed using one-way ANCOVA controlling for age and BMI.

Results
More men had OSA (82.8% vs 56.4%). Men without OSA showed a larger change in CBF after challenge in left (t=2.6, p=0.014) and right (t=2.4, p=0.021) hippocampus. Although the main analyses by severity level only boarded significance, pairwise comparisons indicated men with severe OSA (AHI4%&gt;30/hr) exhibited a larger change in CBF after challenge in the hippocampus overall compared to those with mild OSA (AHI4%5–15/hr; p=0.015) and without OSA (p=0.017). Women with severe OSA showed a reduced change in CBF after challenge in the right hippocampus compared to those with mild (p=0.016), moderate (AHI4%16–29/hr; p=0.008), and without OSA (p=0.015).

Conclusion
This study suggests a possible differential effect of OSA severity and sex on regional CBF in response to a CO2 challenge, specifically in the hippocampus. Further studies will examine cognitive consequences of these sex-specific hippocampal perfusion abnormalities in OSA.

Support
NIH/NIA (1R01HL118624) Osorio, RS 07/01/13-04/30/17 Sleep Disordered Breathing in normal elderly and risk for Alzheimer’s disease (AD).NIH/NIA (R01AG056031S1) Osorio, RS 8/01/2019-7/31/2020 Sleep Aging and Risk for Alzheimer’s disease - Research Supplement to Promote Diversity in Health-Related Research