bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haploidentical stem cell transplant with post-transplantation cyclophosphamide and mini-dose methotrexate in children
Authors: Medina Diego , Estacio Mayra , Rosales Maria , Manzi Eliana 
Published: March 2020

Background:
Haploidentical stem cell transplantation (haplo-SCT) is an option for patients without human leukocyte antigen-matched related or unrelated donor. Post-transplantation cyclophosphamide (PTCy) is an effective method of graft versus host disease (GVHD) prophylaxis and permits the use of T-cell replete grafts in settings were ex vivo manipulation is not feasible.

Methods:
A retrospective study among patients younger than 18 years, with a history of hematologic malignancies who underwent haplo-SCT between 2012 and 2016. All patients received a preparative regimen of fludarabine, busulfan, and 400 cGy total body irradiation or melphalan. Post-transplant GvHD prophylaxis consisted either of PTCy (50 mg/kg on Days + 3 and + 4) and cyclosporine (CSA) plus mycophenolate (MMF) (15 mg/kg/dose, thrice daily, per os), or minidose methotrexate (MTX; 5 mg/m2 dose) on Days + 5, +7, +10, and + 15.

Results:
A +total of 52 children were included, whose median age was 9 years (interquartile range, 4.9–14; range, 1.2–17 years), and 63% were males. The most common complications were cytomegalovirus reactivation (57%) and hemorrhagic cystitis (36%). The acute GVHD prophylaxis was PTCy, CSA, and mini-dose MTX in 42 (81%) patients, and 10 (19%) patients received PTCy, CSA, and MMF. The cumulative incidence of acute GvHD II–IV, acute GvHD III–IV, and chronic GvHD were 42%, 8.5%, and 19%, respectively. Grades I–IV acute GvHD occurred in 100% of the patients who received prophylaxis with CSA and MMF, and 62% who received CSA and mini-dose MTX (p = .055). The transplant-related mortality at 100 days was 18%. The 5-year overall and event-free survival were 59% and 57%, respectively.

Conclusions:
Haplo-SCT with PT/Cy can be an available, safe, and feasible option for children with hematologic malignancies; meanwhile, the use of mini-dose of MTX was associated with lower rates of acute GVHD. However, our results require further support from prospective randomized studies to improve the efficacy of this prophylactic strategy.
The Bilateral Pedicled Epilated Scrotal Flap: A Powerful Adjunctive for Creation of More Neovaginal Depth in Penile Inversion Vaginoplasty
Authors: Nijhuis Tim H.J. , Özer Müjde , van der Sluis Wouter B. , Al-Tamini Muhammed , Salim Ali , Thomas Philip , Bellringer James , Bouman Mark-Bram 
Published: March 2020

Abstract

Background
Penile inversion vaginoplasty is a commonly performed genital gender-affirming procedure in transgender women. The creation of an adequate functional neovaginal depth in cases of too little usable penile skin is a challenge. The bilateral pedicled epilated scrotal flap (BPES-flap) can be used as an easy adjunctive technique and may serve as a tool in the surgical armamentarium of the gender surgeon.

Aim
To describe the use, dissection, design subtypes, and surgical outcomes of the BPES-flap in vaginoplasty.

Methods
Perioperative considerations and different flap design subtypes were described to illustrate the possible uses of the BPES-flap in vaginoplasty. A retrospective chart study was performed on the use of this flap in 3 centers (blinded for review purposes).

Outcomes
The main outcome measures are description of surgical technique, flap design possibilities, and postoperative complications.

Results
A total of 42 transgender women were included (median age: 28 years (range 18–66), mean body mass index: 24.5 ± 3.5). The mean penile length and width preoperatively were 9 ± 3.1 and 2.9 ± 0.2 cm, respectively. With a mean follow up of 13 ± 10 months, total flap necrosis occurred in one case (2.4%). Partial flap necrosis occurred also in one. Neovaginal reconstruction was successful in all patients with a mean vaginal depth of 13.5 ± 1.3 cm and width of 3.3 ± 1.3 cm. Partial prolapse of the neovaginal top occurred in 3 patients (7%).

Clinical Implications
The BPES-flap is a useful addition to the arsenal of surgeons performing feminizing genital reconstructive surgery.

Strengths & Limitations
Strenghts comprise (1) the description of the surgical technique with clear images, (2) completeness of data, and (3) that data are from a multicenter study. A weakness is the retrospective nature with limited follow-up time.

Conclusion
The BPES-flap is a vascularized scrotal flap that can be raised on the bilateral inferior superficial perineal arteries. It may be used for neovaginal depth creation during vaginoplasty and may be quicker to perform than full-thickness skin grafting.
Statewide surveillance of carbapenemase-producing carbapenem-resistant Escherichia coli and Klebsiella species in Washington state, October 2012–December 2017
Authors: Precit Mimi R. , Kauber Kelly , Glover William A. , Weissman Scott J. , Robinson Tashina , Tran Michael , D’Angeli Marisa 
Published: March 2020

AbstractBackground:Carbapenem-resistant Enterobacterales (CRE) are common causes of healthcare-associated infections and are often multidrug resistant with limited therapeutic options. Additionally, CRE can spread within and between healthcare facilities, amplifying potential harms.Objective:To better understand the burden, risk factors, and source of acquisition of carbapenemase genes in clinical Escherichia coli and Klebsiella spp isolates from patients in Washington to guide prevention efforts.Design:Multicenter prospective surveillance study.Methods:Escherichia coli and Klebsiella spp isolates meeting the Washington state CRE surveillance case definition were solicited from clinical laboratories and tested at Washington Public Health Laboratories using polymerase chain reaction (PCR) for the 5 most common carbapenemase genes: blaKPC, blaNDM, blaIMP, blaVIM, and blaOXA-48. Case patients positive by PCR were investigated by the public health department.Results:From October 2012 through December 2017, 363 carbapenem-resistant E. coli and Klebsiella spp isolates were tested. Overall, 45 of 115 carbapenem-resistant K. pneumoniae (39%), 1 of 8 K. oxytoca (12.5%), and 28 of 239 carbapenem-resistant E. coli (11.7%) were carbapenemase positive. Of 74 carbapenemase-positive isolates, blaKPC was most common (47%), followed by blaNDM (30%), blaOXA-48 (22%), and blaIMP (1%). Although all cases had healthcare exposure, blaKPC acquisition was associated with US health care, whereas non-blaKPC acquisition was associated with international health care or travel.Conclusions:We report that blaKPC, the most prevalent carbapenemase in the United States, accounts for nearly half of carbapenemase cases in Washington state and that most KPC-cases are likely acquired through in-state health care.
Navigating Formal and Informal Processes: Civic Organizations, Armed Nonstate Actors, and Nested Governance in Colombia
Authors: Larratt-Smith Charles 
Published: March 2020

ABSTRACTDespite the recent surge of scholarship on the role that civic organizations play in armed conflicts and postconflict settings, there is little consensus on how they interact with armed nonstate actors. This article examines how disparate armed nonstate actors can co-opt and manage preexisting civic organizations, and even create new ones, to embed themselves in civilian communities and perform governance functions while simultaneously advancing their ideological agendas. Employing a comparative historical analysis between two armed nonstate units in Colombia, one from a Marxist insurgent group and the other from a counterinsurgent paramilitary organization, the study demonstrates that regardless of their different ideological motivations, regional settings, and repertoires of violence, these actors could navigate formal processes related to legal economies, electoral contests, and bureaucratic-administrative institutions, and informal processes tied to illicit rackets and territorial and population control, more efficiently through their skilled management of local civic organizations.
Dietary Approaches to Stop Hypertension (DASH) diet and associated socio-economic inequalities in the UK
Authors: Patel Linia , Alicandro Gianfranco , La Vecchia Carlo 
Published: March 2020

AbstractThe Dietary Approaches to Stop Hypertension (DASH) diet is an effective measure in the prevention and treatment of CVD. We evaluated recent trends in socio-economic differences in the DASH score in the UK population, using education, occupation and income as proxies of socio-economic position (SEP). We analysed data on 6416 subjects aged 18 years and older collected in the National Diet and Nutrition Survey (2008–2016). The DASH score was calculated using sex-specific quintiles of DASH items. Multiple linear regression and quantile regression models were used to evaluate the trend in DASH score according to SEP. The mean DASH score was 24 (sd 5). The estimated mean difference between people with no qualification and those having the highest level of education was −3·61 (95 % CI −4·00, −3·22) points. The mean difference between subjects engaged in routine occupations and those engaged in high managerial and professional occupations was −3·41 (95 % CI −3·89, −2·93) points and for those in the first fifth and last fifth of the household income distribution was −2·71 (95 % CI −3·15, −2·28) points. DASH score improved over time, and no significant differences in the trend were observed across SEP. The widest socio-economic differences emerged for consumption of fruit, vegetables, whole grains, nuts, seeds and legumes. Despite an overall increase in the DASH score, a persisting SEP gap was observed. This is an important limiting factor in reducing the high socio-economic inequality in CVD observed in the UK.
‘A Blot on English Justice’: India reformism and the rhetoric of virtual slavery
Authors: LEONARD ZAK 
Published: March 2020

AbstractBeginning in the late 1830s, a coalition of non-conformists, abolitionists, free traders, and disenchanted East India Company proprietors began to vocally challenge the exploitative policies of the colonial state in British India. Led by lecturer George Thompson, these reformers pursued a rhetorical strategy of associating groups who were converted into ‘mere tools’ by the Company abroad and the aristocracy at home. These monopolistic entities degraded Indian peasant cultivators, the British working classes, and princely sovereigns alike through forms of ‘virtual slavery’ that persisted in the post-Emancipation empire. In staging these protests, reformers ran up against an adversarial Board of Control and Court of Directors who obstructed their efforts to mobilize public opinion. Probing their agitation reveals the existence of a particularly combative strain of liberal imperialist thought that defied the political status quo.
Voicing alternation and sigmatic causative prefixation in Tibetan
Authors: Jacques Guillaume 
Published: March 2020

AbstractThe present paper discusses the hypothesis according to which a devoicing sound shift*sb->sp-,*sd->st-,*sg->sk-took place in pre-Tibetan. I show that all examples supporting this putative sound shift have better explanations, and that this hypothesis creates more problems than it solves. In addition, I discuss data from modern Tibetic varieties, showing that no typological parallel for such a sound shift is attested.
Lacan in the US cyber defence: Between public discourse and transgressive practice
Authors: Jacobsen Jeppe T. 
Published: March 2020

AbstractEdward Snowden exposed the discrepancy between the official US defence discourse of liberal values in cyberspace and secret surveillance and cyber exploitation practices. Situated in the critical literature on security and surveillance, the article proposes that more attention needs to be paid to the constitutive role of transgressive practices for security communities. The article introduces a Lacanian strategy for studying transgression in the US cyber defence community. Through this strategy, a transgressive other – in this case, China in cyberspace – enters the fantasy of the US cyber defence community as the symptom that conceals more fundamental tensions in the US cyber defence. But the community's representation of China in cyberspace represents more than that; China is a fantasmatic object that structures and gives content to a desire for transgressing the official ideals of the US cyber defence. This is why the excessive cyber practices that China is criticised for conducting mirror the secret, disavowed transgressions of the US cyber defence. Transgressions, the article concludes through Lacan, provide the necessary (partial) enjoyment that sustains the US cyber defence community as a solidarity-in-guilt and the official US cyber defence discourse.
The monolingual problem of computer-assisted language learning
Authors: Buendgens-Kosten Jules 
Published: March 2020

AbstractThis paper sets out to discuss the monolingual problem within computer-assisted language learning (CALL) research and CALL product development, namely a lack of knowledge about how CALL products and projects can support learners in using all their linguistic resources to achieve language-learning- and language-using-related goals, and a lack of CALL products and projects that realize this potential, or that support specific plurilingual skill development. It uses an analysis of CALL-related papers to demonstrate how far CALL is impacted by a monolingual bias that it inherited from language learning pedagogy. An analysis of articles from four CALL journals across 10 years shows that although the words bilingual and multilingual appear in these journals fairly regularly, terms such as plurilingual, third language, tertiary language, L3, translanguaging, and translingual are extremely rare. Also, only eight articles could be identified that use any of these eight keywords in their title. Trends across those papers are identified. In a discussion of existing CALL products and projects that incorporate more than one language, it is argued that while commercial products often include more than one language, this is frequently in a behaviorist or grammar-translation tradition, while innovative plurilingual products and projects tend to be non-commercial and often EU/EC-funded initiatives. The article argues that CALL research and product development can not only avoid this monolingual bias, but also actively contribute to our knowledge of how all linguistic resources can be used for language learning. It makes suggestions for relevant future research areas related to multilingual computer-assisted language learning (MCALL).
Microstructure of the Corpus Callosum Long after Pediatric Concussion
Authors: Sohn Maya N. , Virani Shane , Carlson Helen L. , MacPhail Shelby , Low Trevor A. , Plourde Vickie , Yeates Keith Owen , Lebel Catherine , Brooks Brian L. 
Published: March 2020

AbstractObjective:The long-term effects of pediatric concussion on white matter microstructure are poorly understood. This study investigated long-term changes in white matter diffusion properties of the corpus callosum in youth several years after concussion.Methods:Participants were 8–19 years old with a history of concussion (n = 36) or orthopedic injury (OI) (n = 21). Mean time since injury for the sample was 2.6 years (SD = 1.6). Participants underwent diffusion magnetic resonance imaging, completed cognitive testing, and rated their post-concussion symptoms. Measures of diffusivity (fractional anisotropy, mean, axial, and radial diffusivity) were extracted from white matter tracts in the genu, body, and splenium regions of the corpus callosum. The genu and splenium tracts were further subdivided into 21 equally spaced regions along the tract and diffusion values were extracted from each of these smaller regions.Results:White matter tracts in the genu, body, and splenium did not differ in diffusivity properties between youth with a history of concussion and those with a history of OI. No significant group differences were found in subdivisions of the genu and splenium after correcting for multiple comparisons. Diffusion metrics did not significantly correlate with symptom reports or cognitive performance.Conclusions:These findings suggest that at approximately 2.5 years post-injury, youth with prior concussion do not have differences in their corpus callosum microstructure compared to youth with OI. Although these results are promising from the perspective of long-term recovery, further research utilizing longitudinal study designs is needed to confirm the long-term effects of pediatric concussion on white matter microstructure.
Sea Ice Thickness and Elastic Properties From the Analysis of Multimodal Guided Wave Propagation Measured With a Passive Seismic Array
Authors: Moreau Ludovic , Boué Pierre , Serripierri Agathe , Weiss Jérôme , Hollis Daniel , Pondaven Ildut , Vial Benjamin , Garambois Stéphane , Larose Éric , Helmstetter Agnés , Stehly Laurent , Hillers Gregor , Gilbert Olivier 
Published: March 2020

AbstractField data are needed for a better understanding of sea ice decline in the context of climate change. The rapid technological and methodological advances of the last decade have led to a reconsideration of seismic methods in this matter. In particular, passive seismology has filled an important gap by removing the need to use active sources. We present a seismic experiment where an array of 247 geophones was deployed on sea ice, in the Van Mijen fjord near Sveagruva (Svalbard). The array is a mix of 1C and 3C stations with sampling frequencies of 500 and 1000 Hz. They recorded continuously the ambient seismic field in sea ice between 28 February and 26 March 2019. Data also include active acquisitions on 1 and 26 March with a radar antenna, a shaker unit, impulsive sources, and artificial sources of seismic noise. This data set is of unprecedented quality regarding sea ice seismic monitoring, as it also includes thousands of microseismic events recorded each day. By combining passive seismology approaches with specific array processing methods, we demonstrate that the multimodal dispersion curves of sea ice can be calculated without an active source and then used to infer sea ice properties. We calculated an ice thickness, Young's modulus, and Poisson's ratio with values h=54±3 cm, E=3.9±0.15 GPa, and ν=0.34±0.02 on 1 March, and h=58±3 cm, E=4.4±0.15 GPa, and ν=0.32±0.02 on 5 March. These values are consistent with in situ field measurements and observations.
Evaluation of Radial Ocean Surface Currents Derived From Sentinel‐1 IW Doppler Shift Using Coastal Radar and Lagrangian Surface Drifter Observations
Authors: Moiseev A. , Johnsen H. , Hansen M. W. , Johannessen J. A. 
Published: March 2020

AbstractOcean surface radial velocities (RVLs) derived from the Sentinel‐1 A/B Interferomic Wide (IW) mode Doppler frequency shift observations are regularly acquired over the Norwegian coastal zone. These data can be used to complement existing ocean observation systems with high‐resolution (up to 1.5 × 1.5 km) spatial ocean surface current (OSC) maps. In this study, Sentinel‐1 IW Level 2 OSC retrievals were obtained from 2 months (October–November 2017) of raw Doppler shift observations acquired over the Norwegian Coastal Current (NCC). The results were evaluated using coastal high‐frequency radar (HFR) and Lagrangian ocean surface drifter observations. The analysis shows that distinct patterns of the NCC, with range directed currents reaching up to 0.7 m/s, can be detected in the SAR data. The mean bias between Synthetic Aperture Radar (SAR) and HFR observations was −0.08 m/s and the root mean square deviation (RMSD) was 0.25 m/s. In comparison, the agreement between the SAR‐derived OSC and the trajectories from Lagrangian surface drifters showed a mean bias of 0.02 m/s and an RMSD of 0.24 m/s. The accuracy of the SAR OSC retrievals rely on precise wind‐wave bias correction. Hence, the accuracy of the model wind field (speed and direction) is crucial. The sea state contribution must also be taken into account during the bias correction. A typical required accuracy of the OSC velocity is on the order of 0.1 m/s. Therefore, the comparisons demonstrate that the use of SAR for OSC retrieval is promising.
A Satellite Era Warming Hole in the Equatorial Atlantic Ocean
Authors: Nnamchi Hyacinth C. , Latif Mojib , Keenlyside Noel S. , Park Wonsun 
Published: March 2020

AbstractObservations during the satellite era 1979–2018 only depict small sea surface temperature (SST) trends over the Equatorial Atlantic cold tongue region in boreal summer. This lack of surface warming of the cold tongue, termed warming hole here, denotes an 11% amplification of the mean SST annual cycle. The warming hole is driven by a shoaling of the equatorial thermocline, linked to increased wind stress forcing, and damped by the surface turbulent heat fluxes. The satellite era warming deficit is not unusual during the twentieth century—similar weak trends were also observed during the 1890s–1910s and 1940s–1960s. The tendency for surface cooling appears to reflect an interaction of external forcing, which controls the timing and magnitude of the cooling, with the intrinsic variability of the climate system. The hypothesis for externally forced modulation of internal variability is supported by climate model simulations forced by the observed time‐varying concentrations of atmospheric greenhouse gases and natural aerosols. These show that increased greenhouse forcing warmed the cold tongue and aerosols cooled it during the satellite era. However, internal variability, as derived from control integrations with fixed, preindustrial values of greenhouse gases and aerosols, can potentially cause larger cooling than observed during the satellite era. Large uncertainties remain on the relative roles of external forcing and intrinsic variability in both observations and coupled climate models.
Impedance and Voltage Power Spectra of a Monopole Antenna in a Warm Plasma—Derivation and Application to CubeSats
Authors: Maj Ronald , Cairns Iver H. , Martinović M. M. 
Published: March 2020

AbstractThe impedance for a monopole antenna in a warm plasma is derived and compared with the cases for wire dipole and double‐sphere antennas. This derivation produces a new expression for the monopole antenna response function, Fm1(x), which is very similar to the double‐sphere antenna response function. The monopole, wire dipole, and double‐sphere response functions are compared by modeling an antenna in Earth's ionospheric plasma (i.e., electrostatic and collisionless) and predicting the antenna capacitance and voltage power spectra for quasi‐thermal noise (QTN) and shot noise. Specifically, we assume the antennas are part of a CubeSat, which has spurred this research as most interplanetary craft carry a dipole or more complicated antenna designs on board (Imbriale, 2006, https://doi.org/10.1002/0470052783.ch3; Imbriale, Gatti et al., 2006, https://doi.org/10.1002/0470052783.ch5). The monopole antenna current distribution is assumed to be a half‐triangular current distribution (considering only the positive half of the triangular distribution), which follows that of prior authors (Balmain, 1965, https://doi.org/10.6028/jres.069D.065; Kuehl, 1966, https://doi.org/10.1002/rds196618971; Couturier et al., 1981, https://doi.org/10.1029/JA086iA13p11127) and simplifies comparison. The predictions for the shot noise and capacitance presented problems, as the integral over wave number space or k space did not converge for large values of k. The derived expression therefore remains a current problem in these situations, and no alternative has been found in the existing literature, necessitating future work to determine a more general expression. In this paper we bring the problem of an appropriate analytic monopole antenna response function to the attention of the community and outline a number of tests that can be used to verify any future expression.