bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of the interleukin-17A pathway in endometrial tissue from women with unexplained infertility affects pregnancy outcome following assisted reproductive treatment
Authors: Crosby D A , Glover L E , Brennan E P , Kelly P , Cormican P , Moran B , Giangrazi F , Downey P , Mooney E E , Loftus B J , McAuliffe F M , Wingfield M , O’Farrelly C , Brennan D J 
Published: April 2020

AbstractSTUDY QUESTIONWhich transcriptomic alterations in mid-luteal endometrial scratch biopsies, taken prior to the assisted reproductive treatment (ART) treatment cycle are associated with unsuccessful pregnancy?SUMMARY ANSWERDysregulated interleukin-17 (IL-17) pathway components are demonstrated in women who fail to become pregnant after ART.WHAT IS KNOWN ALREADYImplantation failure is now recognised as a critical factor in unexplained infertility and may be an important component of failed ART.STUDY DESIGN, SIZE, DURATIONUsing a prospective longitudinal study design, 29 nulliparous women with unexplained infertility undergoing ART were recruited between October 2016 and February 2018. Mid-luteal stage endometrium and matched serum samples were collected, and patients underwent a single embryo transfer in the subsequent cycle. RNA-seq analysis of endometrial biopsies was performed on the discovery cohort (n = 20).PARTICIPANTS/MATERIALS, SETTING, METHODSGene set enrichment analysis of the differentially expressed genes (DEGs) was performed. Endometrium and serum were then prepared for IL-17A analysis by ELISA.MAIN RESULTS AND THE ROLE OF CHANCEThere were 204 differentially expressed protein-coding genes identified in tissue from women who became pregnant (n = 9) compared with tissue from women who failed to become pregnant (n = 11) (false discovery rate; P &lt; 0.05). Of the 204 DEGs, 166 were decreased while 38 were increased in the pregnant compared to the non-pregnant groups. Gene set enrichment analysis of the DEGs identified an over-representation of IL-17 and Pl3K-Akt signalling pathways. All the DEGs within the IL-17 signalling pathway (MMP3, MMP1, IL1β, LCN2, S100A9 and FOSL1) demonstrated decreased expression in the pregnant group. Serum IL-17 protein levels were increased in the non-pregnant discovery cohort (n = 11) and these findings were confirmed a validation cohort (n = 9).LIMITATIONS, REASONS FOR CAUTIONLimitations of our study include the cohort size and the lack of aneuploidy data for the embryos; however, all embryos transferred were single good or top-quality blastocysts.WIDER IMPLICATIONS OF THE FINDINGSThese findings demonstrate dysregulated IL-17 pathway components in women who fail to become pregnant after ART. Elevated serum levels of the pro-inflammatory cytokine IL-17 may predict failure of ART in women with unexplained infertility. Future trials of anti-IL-17 therapies in this cohort warrant further investigation.STUDY FUNDING/COMPETING INTEREST(S)Funding from the UCD Wellcome Institutional Strategic Support Fund, which was financed jointly by University College Dublin and the SFI-HRB-Wellcome Biomedical Research Partnership (ref 204844/Z/16/Z), is acknowledged. The authors have no competing interests.TRIAL REGISTRATION NUMBERNA.
Giant right ventricle infiltrative lipoma—a surgical success report
Authors: Mizrahi Michelle , Jimenez-Becerra Silvia , Castro-Lozano Guillermo E , Gómez-Sánchez Mario 
Published: April 2020

Abstract
Benign primary cardiac tumours are rare, with lipomas accounting for &lt;9% of them. Their presentation varies depending on the size and location of the tumour, with the majority of the cases being asymptomatic. We are presenting a case of an extremely rare primary heart-tumour infiltrating the right ventricle (RV) compromising its function. RV lipomas are so unusual that there are no clear treatment guidelines. In this case, we decided to treat the patient with surgical resection of the tumour. Although a total resection was not possible, due to the tumoural proximity to vital structures, a great portion of the tumour was removed, alleviating the patient’s symptoms.
A review of coupled heat and mass transfer in adiabatic liquid desiccant dehumidification and regeneration systems; advances and opportunities
Authors: Oyieke Andrew A Y , Inambao Freddie L 
Published: April 2020

AbstractIn this paper, a comprehensive technical review of liquid desiccant (LD) dehumidification and regeneration techniques is presented. The operational features, processes and performance indices of various flow configurations of adiabatic dehumidifier and regenerator are extensively covered. The heat and mass transfer assessment is presented in terms of past experimental and modelling evaluations and procedures. The existing adiabatic dehumidifier/regenerator heat and mass transfer models are categorized into finite difference, effectiveness-number of transfer units and simple empirical correlation models. The respective performance prediction models are critically analysed in details and compared in terms of assumptions, iterative procedures, solution methods, accuracy, computation time, output variables and applications. The solar regenerator models are also highlighted with a focus on the collector module. The ideal settings, formulation procedures, current state-of-the-art and opportunities for improvements are outlined. The review provides meaningful insight into the research status and available opportunities in the LD adiabatic dehumidifier and regenerator modelling and optimization as well as conceptualization of the applicable models. Finally, some very impactful suggestions for improvement and further research are outlined.
Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials
Authors: Saad Ziad , Hibar Derrek , Fedgchin Maggie , Popova Vanina , Furey Maura L , Singh Jaskaran B , Kolb Hartmuth , Drevets Wayne C , Chen Guang 
Published: April 2020

AbstractBackgroundAt ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has shown mu-opioid receptor (MOR–gene symbol: OPRM1) agonist effects. Preliminary clinical studies showed conflicting results on whether naltrexone, a MOR antagonist, blocks the antidepressant action of ketamine. We examined drug-induced or endogenous MOR involvement in the antidepressant and dissociative responses to esketamine by assessing the effects of a functional single nucleotide polymorphism rs1799971 (A118G) of OPRM1, which is known to alter MOR agonist-mediated responses.MethodsParticipants with treatment-resistant depression from 2 phase III, double-blind, controlled trials of esketamine (or placebo) nasal spray plus an oral antidepressant were genotyped for rs1799971. Participants received the experimental agents twice weekly for 4 weeks. Antidepressant responses were rated using the change in Montgomery–Åsberg Depression Rating Scale (MADRS) score on days 2 and 28 post-dose initiation, and dissociative side effects were assessed using the Clinician-Administered Dissociative-States Scale at 40 minutes post-dose on days 1 and 25.ResultsIn the esketamine + antidepressant arm, no significant genotype effect of single nucleotide polymorphism rs1799971 (A118G) on MADRS score reductions was detected on either day 2 or 28. By contrast, in the antidepressant + placebo arm, there was a significant genotype effect on MADRS score reductions on day 2 and a nonsignificant trend on day 28 towards an improvement in depression symptoms in G-allele carriers. No significant genotype effects on dissociative responses were detected.ConclusionsVariation in rs1799971 (A118G) did not affect the antidepressant response to esketamine + antidepressant. Antidepressant response to antidepressant + placebo was increased in G-allele carriers, compatible with previous reports that release of endorphins/enkephalins may play a role in mediating placebo effect.Trial RegistrationNCT02417064 and NCT02418585; www.clinicaltrials.gov
Real Tropicalization and Analytification of Semialgebraic Sets
Authors: Jell Philipp , Scheiderer Claus , Yu Josephine 
Published: April 2020

Abstract
Let $K$ be a real closed field with a nontrivial non-archimedean absolute value. We study a refined version of the tropicalization map, which we call real tropicalization map, that takes into account the signs on $K$. We study images of semialgebraic subsets of $K^n$ under this map from a general point of view. For a semialgebraic set $S \subseteq K^n$ we define a space $S_r^{{\operatorname{an}}}$ called the real analytification, which we show to be homeomorphic to the inverse limit of all real tropicalizations of $S$. We prove a real analogue of the tropical fundamental theorem and show that the tropicalization of any semialgebraic set is described by tropicalization of finitely many inequalities, which are valid on the semialgebraic set. We also study the topological properties of real analytification and tropicalization. If $X$ is an algebraic variety, we show that $X_r^{{\operatorname{an}}}$ can be canonically embedded into the real spectrum $X_r$ of $X$, and we study its relation with the Berkovich analytification of $X$.
Incorporating home healthcare nurses’ admission information needs to inform data standards
Authors: Sockolow Paulina S , Bowles Kathryn H , Wojciechowicz Christine , Bass Ellen J 
Published: April 2020

Abstract

Objective
Patient transitions into home health care (HHC) often occur without the transfer of information needed for critical clinical decisions and the plan of care. Owing to a lack of universally implemented standards, there is wide variation in information transfer. We sought to characterize missing information at HHC admission.

Materials and Methods
We conducted a mixed methods study with 3 diverse HHC agencies. Focus groups with nurses at each agency identified what information supports patient care decisions at admission. Thirty-six in-home admissions with associated documentation review determined the available information. To inform information standards development for the HHC admission process, we compared the types of information desired and available to an international standard for transitions in care information, the Continuity of Care Document (CCD) enhanced with Office of the National Coordinator for Healthcare Information Technology summary terms (CCD/S).

Results
Three-quarters of the items from the focus groups mapped to the CCD/S. Regarding available information at admission, no observation included all CCD/S data items. While medication information was needed and often available for 4 important decisions, concepts related to patient medication self-management appeared in neither the CCD/S nor the admission documentation.

Discussion
The CCD/S mostly met HHC nurses’ information needs and is recommended to begin to fill the current information gap. Electronic health record recommendations include use of a data standard: the CCD or the proposed, more parsimonious U.S. Core Data for Interoperability.

Conclusions
Referral source and HHC agency adoption of data standards is recommended to support structured, consistent data and information sharing.
MINIMAR (MINimum Information for Medical AI Reporting): Developing reporting standards for artificial intelligence in health care
Authors: Hernandez-Boussard Tina , Bozkurt Selen , Ioannidis John P A , Shah Nigam H 
Published: April 2020

Abstract
The rise of digital data and computing power have contributed to significant advancements in artificial intelligence (AI), leading to the use of classification and prediction models in health care to enhance clinical decision-making for diagnosis, treatment and prognosis. However, such advances are limited by the lack of reporting standards for the data used to develop those models, the model architecture, and the model evaluation and validation processes. Here, we present MINIMAR (MINimum Information for Medical AI Reporting), a proposal describing the minimum information necessary to understand intended predictions, target populations, and hidden biases, and the ability to generalize these emerging technologies. We call for a standard to accurately and responsibly report on AI in health care. This will facilitate the design and implementation of these models and promote the development and use of associated clinical decision support tools, as well as manage concerns regarding accuracy and bias.
The Role of Cognitive Bias in Breast Radiology Diagnostic and Judgment Errors
Authors: Loving Vilert A , Valencia Elizabeth M , Patel Bhavika , Johnston Brian S 
Published: April 2020

Abstract
Cognitive bias is an unavoidable aspect of human decision-making. In breast radiology, these biases contribute to missed or erroneous diagnoses and mistaken judgments. This article introduces breast radiologists to eight cognitive biases commonly encountered in breast radiology: anchoring, availability, commission, confirmation, gambler’s fallacy, omission, satisfaction of search, and outcome. In addition to illustrative cases, this article offers suggestions for radiologists to better recognize and counteract these biases at the individual level and at the organizational level.
Aerial and aquatic respiration in littoral Oniscidea (Isopoda) from Southern California, USA
Authors: Wright Jonathan C , Harris Zechariah C 
Published: April 2020

AbstractThe large radiation of terrestrial isopods (suborder Oniscidea) includes several families that are represented primarily in marine-littoral or riparian habitats. Among these are members of Ligiidae and Tylidae as well as several basal families within the section Crinocheta. Structural and physiological evidence supports a marine-littoral ancestry of the Oniscidea. We examined aerial and aquatic respiration (measured as VCO2) in six species of marine-littoral Oniscidea representing five families, as well as one riparian and one endogean species. Complimentary data were collected for immersion tolerance and whole-animal permeability in air, and structural specialization of the respiratory pleopods was examined using SEM. Ligia occidentalis Dana, 1853 (marine, littoral) and Ligidium lapetum Mulaik & Mulaik, 1942 (riparian) showed similar VCO2 in air and water. VCO2 in air for the other species was significantly higher than in water. Compared across species, aerial VCO2 scaled with mass in accordance with Kleiber’s law (β = 0.774) while aquatic VCO2 increased in approximate proportion to mass (β = 0.957). At least some specimens of the six marine-littoral species survived over 24 h immersion. Ligidium lapetum and the endogean trichoniscid Brackenridgia heroldi (Arcangeli, 1932) also tolerated prolonged immersion in freshwater but did not survive beyond 5–6 h, probably due to limited capacity for hyper-regulation. The upper shore sand-burrowers, Tylos punctatus Holmes & Gay, 1909 and Alloniscus perconvexus Dana, 1856 had the lowest permeability among the study species and are the only representatives with elaborated pleopodal respiratory fields (Alloniscus) and lungs (Tylos). The ventral lung spiracles of T. punctatus are surrounded by an extensive cuticle meshwork and we propose that this functions as a plastron field to enhance aquatic gas exchange. Collectively, the results show that littoral species tolerate significant periods of immersion, allowing them to withstand habitat inundation during spring high tides, storm swells and, in riparian species, rainstorms and snowmelt.
Honey Bee Queen Production: Canadian Costing Case Study and Profitability Analysis
Authors: Bixby Miriam , Hoover Shelley E , McCallum Robyn , Ibrahim Abdullah , Ovinge Lynae , Olmstead Sawyer , Pernal Stephen F , Zayed Amro , Foster Leonard J , Guarna M Marta 
Published: April 2020

Abstract
The decline in managed honey bee (Hymenoptera: Apidae) colony health worldwide has had a significant impact on the beekeeping industry. To mitigate colony losses, beekeepers in Canada and around the world introduce queens into replacement colonies; however, Canada’s short queen rearing season has historically limited the production of early season queens. As a result, Canadian beekeepers rely on the importation of foreign bees, particularly queens from warmer climates. Importing a large proportion of (often mal-adapted) queens each year creates a dependency on foreign bee sources, putting beekeeping, and pollination sectors at risk in the event of border closures, transportation issues, and other restrictions as is currently happening due to the 2020 Covid-19 pandemic. Although traditional Canadian queen production is unable to fully meet early season demand, increasing domestic queen production to meet mid- and later season demand would reduce Canada’s dependency. As well, on-going studies exploring the potential for overwintering queens in Canada may offer a strategy to have early season domestic queens available. Increasing the local supply of queens could provide Canadian beekeepers, farmers, and consumers with a greater level of agricultural stability and food security. Our study is the first rigorous analysis of the economic feasibility of queen production. We present the costs of queen production for three Canadian operations over two years. Our results show that it can be profitable for a beekeeping operation in Canada to produce queen cells and mated queens and could be one viable strategy to increase the sustainability of the beekeeping industry.
Trapping White-Tailed Deer (Artiodactyla: Cervidae) in Suburbia for Study of Tick–Host Interaction
Authors: Roden-Reynolds Patrick , Machtinger Erika T , Li Andrew Y , Mullinax Jennifer M 
Published: April 2020

Abstract
Live capture of white-tailed deer (Odocoileus virginianus) (Zimmermann, 1780) is often necessary for research, population control, disease monitoring, and parasite surveillance. We provide our deer trapping protocol used in a tick-host vector ecology research project and recommendations to improve efficiency of deer trapping programs using drop nets in suburban areas. We captured 125 deer across two trapping seasons. Generally, lower daily minimum temperatures were related to increased capture probability, along with the presence of snow. Our most successful trapping sites were less forested, contained more fragmentation, and greater proportion of human development (buildings, roads, recreational fields). To improve future suburban deer trapping success, trapping efforts should include areas dominated by recreational fields and should not emphasize remote, heavily forested, less fragmented parks. Concurrently, our study illustrated the heterogeneous nature of tick distributions, and we collected most ticks from one trapping site with moderate parameter values between the extremes of the most developed and least developed trapping sites. This emphasized the need to distribute trapping sites to not only increase your capture success but to also trap in areas across varying levels of urbanization and fragmentation to increase the probability of parasite collection.
Factors associated with health-related quality of life in patients with glioma: impact of symptoms and implications for rehabilitation
Authors: Umezaki Shigeko , Shinoda Yusuke , Mukasa Akitake , Tanaka Shota , Takayanagi Shunsaku , Oka Hiroyuki , Tagawa Hisato , Haga Nobuhiko , Yoshino Mariko 
Published: April 2020

Abstract

Objective
The factors associated with health-related quality of life in patients with glioma remain unclear; particularly, the impact of symptoms on quality of life has not been studied comprehensively. This study aims to document the quality of life of patients with glioma and clarify the impact of symptoms.

Methods
In this cross-sectional study, participants were recruited from patients at The University of Tokyo Hospital and from patients who were registered at the Japan Brain Tumor Alliance. We included adult patients with World Health Organization grade II–IV glioma and excluded those with disturbances of consciousness or aphasia. We used the European Organization for Research and Treatment of Cancer QLQ-C30 and BN20 to evaluate quality of life and the symptoms. Multiple regression analyses were performed to investigate the impact of symptoms on European Organization for Research and Treatment of Cancer global health status and QLQ-C30 social functioning. In addition, we performed univariate subgroup analyses classified by World Health Organization grade and history of chemotherapy.

Results
This study included 76 patients. Seven symptoms occurred in more than 50% of the patients: fatigue, future uncertainty, drowsiness, communication deficit, financial difficulties, motor dysfunction and weakness of legs. Multiple regression analyses showed that insomnia affected their global health status, and appetite loss, financial difficulties and motor dysfunction were significantly related to their social functioning. In subgroup analysis, the number of symptom subscales that were significantly related to global health status and social functioning was larger in World Health Organization grade II patients compared with grade III/IV patients.

Conclusions
In addition to neurological deficits, symptoms were associated with poor quality of life in patients with glioma. This study provided the basis on further investigation of usefulness of symptom evaluation on quality of life improvement.
Spinocerebellar Ataxia Type 3: A Case Report and Literature Review
Authors: McCord Matthew R , Bigio Eileen H , Kam Kwok Ling , Fischer Victoria , Obeidin Farres , White Charles L , Brat Daniel J , Muller William A , Mao Qinwen 
Published: April 2020

Abstract
Spinocerebellar ataxia type 3 (SCA3), also known by the eponym Machado-Joseph disease, is an autosomal dominant CAG trinucleotide (polyglutamine) repeat disease that presents in young- to middle-aged adults. SCA3 was first described in Azorean individuals and has interesting epidemiological patterns. It is characterized clinically by progressive ataxia and neuropathologically by progressive degenerative changes in the spinal cord and cerebellum, along with degeneration of the cortex and basal ganglia. Here, we describe the clinical and neuropathologic features in a case of SCA3 with unique findings, including involvement of the inferior olivary nucleus and cerebellar Purkinje cell layer, which are classically spared in the disease. We also discuss research into the disease mechanisms of SCA3 and the potential for therapeutic intervention.