bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutrition peculiarities and level of awareness in the issues of rational nutrition of the working population of the Sverdlovsk region
Authors: Semenova L. V. , Mironova E. N. , Zhuravleva P. V. 
Published: December 2024

Introduction. The peculiarities of the culture of food consumption and the level of awareness in matters of nutrition of the working population of the Sverdlovsk region have been analyzed, the trends contributing to the formation of irrational nutrition have been noted, and recommendations for preventive work have been formulated.The purpose of the study: to identify the peculiarities of food consumption culture and to determine the level of awareness of nutrition among the working population of the Sverdlovsk region.Materials and methods. A quantitative method was used – an online survey using Computer Assisted WEB Interviewing (CAWI) technology with 2,500 respondents. Quota sampling by gender and age of respondents, with the deﬁnition of the territory of residence was calculated.Results. The number of meals inappropriate to the recommendations, predominance of carbohydrate component in breakfasts and low representation of vegetables and fruits at any meal were revealed. The tendency to prepare food at home remains. A high level of awareness of working residents of the Sverdlovsk region on issues of rational nutrition was revealed – 73%, with a low level of awareness of the impact of dietary intake on the risk of chronic non-infectious diseases – 48%.Conclusion. It is recommended to disseminate information on the relationship between nutrition and the risk of occurrence and development of chronic non-communicable diseases. Emphasis is placed on the importance of reading information on food labels to identify “hidden” sugar and salt. At the same time, the importance of informing about the norms of consumption of fruits and vegetables, ﬁsh, salt and sugar, as well as about the beneﬁts of following the recommended dietary regimen was emphasized. The authors note the need for a deeper analysis of the reasons for the discrepancy between the criteria “know” and “apply” in the issues of rational nutrition among the working population of the Sverdlovsk region.
Optical coherence tomography guided additional noevas bioresorbable vascular scaffold in the treatment of iatrogenic coronary artery dissection: A case report
Authors: Zhou Dengshuang , Huang Bobin , Chen Jue , You Qiong , Mo Hailiang , Wu Zijun , Lin Yubiao , Chen Lujun , Fan Junyu , Deng Wenyu , Wu Keng 
Published: December 2024

Abstract

Background: Iatrogenic coronary artery dissection is a potential complication during percutaneous coronary bioresorbable vascular scaffolds placement. We report that significant dissection occurred during post-expansion of the left rotatory branch bioresorbable vascular scaffolds to attach it to the wall. Additional resorbable stents successfully covered the dissection without blood flow restriction.
Casereport: The patient was a 49-year-old male with strong coronary implantable concept and was diagnosed with stable angina pectoris and type 2 diabetes. Coronary angiography showed serious lesions in three vessels. After a Noevas stent was inserted in the proximal segment of the anterior descending branch, secondary dissection occurred in the distal segment of the stent during Optical coherence tomography（OCT） examination when Noevas stent was inserted in the proximal segment of the circumflex branch. A third BVS was inserted to cover the dissection and OCT reexamination showed good adherence. After 6 months of coronary angiography, OCT examination showed no deterioration of the circumflex branch dissection, and the proximal intimal hyperplasia in the proximal BVS was 95%. Scoring balloon and drug balloon dilatation were successfully performed, and right coronary artery dilatation with drug coated balloon was performed. The patient had no symptoms of chest pain after 2 years of follow-up.
Conclusion: Additional bioresorbable vascular scaffold coverage of coronary D-type dissection with the help of imaging tools may be a practical strategy when patients have a strong desire for coronary metal-less implantation. Furthermore, imaging review is recommended especially for diabetics.
Effects of the Oral Health Promotion Program on oral health and oral microbiota in elderly diabetic patients: A quasi-experimental study
Authors: Liu Fan , Song Siping , Huang Shuqi , He Jing , Ye Xin , Hu Liwei , Zeng Xin , Deng Sicheng , Hu Xiuying 
Published: December 2024

Abstract

Background
Diabetes, which is highly prevalent, has become a major contributor to the burden of health care costs worldwide. Recent unequivocal evidence has revealed a bidirectional link between oral health and diabetes. In this study, the effects of the Oral Health Promotion Program (OHPP) on oral hygiene, oral health-related quality of life and glycated haemoglobin (HbA1c) levels were examined. At the same time, microbial changes in the saliva microbiota community were also investigated.
Methods
A quasi-experiment was conducted in regionally representative communities to assess participants’ oral health and oral microbiota. The participants in the intervention group (n = 26) received OHPP during the program, when those in the control group (n = 26) received routine oral care. Clinical parameters were recorded at two different time points: before the study (T0), and 3 months after intervention onset (T1). Oral health was measured via the oral health impact profile (OHIP-14) questionnaire, dental plaque index, HbA1c and mastery of oral health knowledge, and sequencing of the 16S rRNA gene from saliva samples was used to analyze the oral microbiota.
Results
The average age of the final sample was 71.77 years (SD = 6.06), 53.8% (28/52) of whom were male. A reduction in the plaque index and improvements in oral health-related quality of life and mastery of oral health knowledge were observed in the intervention group, and the richness and diversity of the microbiota increased. The relative abundance of Streptococcus decreased significantly in both groups. There was no statistically significant difference in the HbA1c level between two groups.
Conclusions
OHPP superiorly contributes to the improvement of oral health and oral microbiota in elderly diabetic patients. The overarching goal is to introduce attention to the importance of good oral health as a crucial point in preventing and managing diabetes mellitus and thereby contribute to the wellbeing and quality of life in people with diabetes.
Trial registration:
Chinese Clinical Trial Register number ChiCTR2200064453.
Bone and muscle mass characteristics in patients with gastroenteropancreatic neuroendocrine neoplasms
Authors: Aktypis Charalampos , Yavropoulou Maria P. , Efstathopoulos Efstathios , Polychroniadou Despoina , Papatheodoridis George , Kaltsas Gregory 
Published: December 2024

Abstract

Neuroendocrine neoplasms (NEN) are rare tumors arising from neuroendocrine cells most commonly in the gastrointestinal-tract. In recent years, advancements in therapeutics have increased survival rates in patients with NEN leading to a greater clinical burden compared to the general population.
The aim of this single-center case-control study was to investigate the incidence of low bone mass and changes in body-composition in adult patients diagnosed with gastroenteropancreatic-neuroendocrine tumors (GEPNET).
Enrolled participants underwent measurements of bone mineral density (BMD) at the lumbar-spine (LS), femoral-neck (FN), and total-hip (TH) and body-composition analysis with calculation of total fat-mass (TFM) and relative-skeletal-mass-index (RSMI), by Dual-X-Ray absorptiometry.
Ninety GEPNET, patients (28 with Pancreatic-NET; 20 with small-intestine-NET, 42 with gastric-NET), and 50 age and sex-matched controls were enrolled. The mean disease-duration was 5±4.4 years, the majority of patients (54/90) was classified as stage-1, and were not receiving systemic-treatment (76/90). The incidence of osteoporosis/osteopenia was 3-fold higher in the patients'-cohort, compared to controls (OR: 3.17 95%CI 1.16-7.8, p<0,001). Amongst NEN patients GNEN had the lowest bone mass, especially in LS. In addition, GEPNET patients demonstrated significantly lower TFM and RSMI, compared to controls (TFM: 31.6±9.6kg vs. 88.6±8.8kg, respectively p<0.001; RSMI: 6.4±1.1 vs. 8.2±0.6, respectively, p<0.001). Within our patients'-cohort, RSMI was significantly associated with LS-BMD (rho=0.448,p<0.001) and TH-BMD (rho=0.582,p<0.001), and TFM was associated with TH-BMD (rho=0.338,p=0.002).
Patients with GEPNET even at an early stage, exhibit significantly lower bone, muscle and fat-mass compared to the non-NET population, highlighting the importance of life-long monitoring of the musculoskeletal system in these patients.
Factors Associated with Patient and Health Care System Delay Among Migrant and Local Tuberculosis Patients in Istanbul: A Cross-Sectional Study
Authors: Ersözlü Mustafa , Lahmuni Mahmut , Mdal Yasser , Shammoot Moamen , Şen Hatice , Hoşnuter Ahmet Ferit , Giakoup Derya , Karaketir Emine Şeyma , Kılıçaslan Zeki 
Published: December 2024

Abstract

Background
Effective tuberculosis (TB) management requires timely diagnosis and immediate treatment initiation. The urgency for diagnosing and treating TB is particularly acute among immigrants, who face heightened health risks due to factors such as poverty, hazardous working conditions, and limited healthcare access. The objective of this study was to examine the characteristics of patient and health care delays among migrant and local TB patients in Istanbul and to identify factors associated with delays in the diagnosis and treatment of TB in both migrant and local patients.
Methods
This cross-sectional study was conducted in six Tuberculosis Control Dispensaries (TCDs) in Istanbul, the city with the highest number of TB cases in Turkey. A total of 211 TB patients, including 140 local residents and 71 migrants, participated. Data were collected through interviews via a structured questionnaire and patient files, following the patients' consent.
Results
Among migrant patients, the time from the onset of TB-related symptoms to admission to a health institution (patient delay) was 4.7 times longer (95% Confidence Interval [CI] = 1.1–20.9) than that in local resident patients. Compared with local patients, migrant patients were predominantly male, younger, had lower education levels, had a history of previous TB, and were less likely to smoke. Additionally, the frequency of working without insurance and unemployment was greater among migrant patients than among those employed with insurance.
Conclusion
Our research underscores the importance of focusing on the migrant community to achieve tuberculosis control goals, potentially through interventions to increase knowledge of healthcare system access and the significance of working conditions, including health insurance. While we profiled migrant TB patients, qualitative research is needed to elucidate the underlying reasons for delays in diagnosis and treatment.
Translation and Psychometric Validation of the Heart Failure Symptom Tracker (HFaST)
Authors: Perez Maria Inês , Seringa Joana , Magalhães Teresa 
Published: December 2024

Abstract

Background: Heart Failure (HF) is a global public health issue with high morbidity and mortality rates. Symptom management improves HF patients’ quality of life and demonstrates a potential reduction in hospitalisation, particularly among individuals aged 65 and over. This study aimed to translate, cross-culturally adapt and evaluate the psychometric properties of the Heart Failure Symptom Tracker (HFaST) tool for the Portuguese population. Additionally, it aimed to test the hypothesis that higher scores of the HFaST are associated with increased hospitalisations due to HF decompensation.
Methods: This cross-sectional study was conducted in two phases. The first phase involved the linguistic translation and cross-cultural adaptation of the HFaST tool into European Portuguese. Content validity was assessed by a panel of ten experts, who evaluated the clarity, relevance and equivalence of the pre-final version. A pre-test, using cognitive interviews with a sample of forty individuals was conducted to assess the item comprehensibility of the adapted tool. The second phase involved the psychometric validity in a sample of sixty HF patients. Participants completed a demographical and clinical assessment, the Portuguese version of the HFaST tool and the Portuguese version of the KCCQ-23 questionnaire. Additionally, the association between HFaST scores and HF hospitalisations were analysed.
Results: Equivalence between versions showed substantial to perfect agreement, with Fleiss’ k ranging from 0.678 to 1.000. Necessary adjustments were performed. Pre-test confirmed 95% comprehensibility. Internal consistency was acceptable, with a Cronbach’s Alpha of 0.724, moderate to strong inter-item correlations, and significant correlations between the HFaST and the KCCQ-23 items were observed. Additionally, higher HFaST scores were significantly associated with an increased likelihood of hospital admission.
Conclusions: The Portuguese version of the HFaST demonstrated to be a reliable and valid self-management tool for HF patients in Portugal, enhancing symptom monitoring and potentially reducing hospital admissions, thus improving patients’ quality of life.
Clinical Trial Number: not applicable.
Based on CT scans at the 12th thoracic spine level, the skeletal muscle index is independently associated with one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study
Authors: Li En-Li , Huang Cheng-Bin , Chen Zi-Hao , Jin Chen , Ma Run-Xun , Feng Si-Xiang , Yang Lei 
Published: December 2024

Abstract

Background: Research has demonstrated that individuals with sarcopenia or sarcopenic obesity who experience fractures or undergo major surgical interventions exhibit a poorer prognosis compared to the general population. However, few studies have investigated the relationship between the skeletal muscle and adipose tissue indices, as measured at the 12th thoracic spine level, and adverse outcomes following orthopedic surgery. Therefore, this study aimed to prove whether skeletal muscle and adipose tissue index measured by computed tomography (CT) images based on a single layer are associated with one-year postoperative mortality in elderly hip fracture patients.
Methods: A total of 334 participants from two institutions were enrolled in this study to obtain skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous ratio of the fat area (VSR) at T12 levels and divide them into death and survival groups based on the results of follow-up after 1 year. Propensity score matching (PSM) was employed to evaluate one-year postoperative mortality.
Results: Institution 1's results identified that a lower SMI significantly heightened the risk of one-year postoperative mortality (OR=0.799,95%CI 0.677-0.943，P=0.008), making SMI an independent predictor. Institution 2's results identified that age (OR=1.081, 95%CI 1.005-1.163，P=0.036), SMI (OR=0.881, 95%CI 0.784-0.991，P=0.035) as independent predictors of one-year postoperative mortality in elderly hip fracture. Receiver operator characteristics analysis revealed area under the curve (AUC) values for institution 1: SMI (0.738 (95%CI 0.626-0.851), significant), VFI (0.605 (95%CI 0.476-0.734)), VSR (0.583 (95%CI 0.451-0.715)); and for institution 2: SMI (0.742 (95%CI 0.612-0.872), significant) and Age (0.775 (95%CI 0.677-0.874), significant). Collectively, these results underscore that SMI serves as an independent predictor of one-year postoperative mortality in elderly hip fracture patients.
Conclusion: This study demonstrated that the T12-based SMI was independently associated with one-year mortality following hip fracture in geriatric patients, with lower preoperative SMI correlating with higher mortality rates post-surgery.
Continuous measurement of pulse wave velocity during general anaesthesia using carotid and femoral Doppler
Authors: Harlé Théophile , Joachim Jona , Boutouyrie Pierre , Mateo Joaquim , Perdereau Jade , Mebazaa Alexandre , Cartailler Jérome , Vallée Fabrice 
Published: December 2024

Abstract

Objective
Pulse wave velocity (PWV), a measure of arterial stiffness, varies with mean arterial pressure (MAP). As general anesthesia (GA) causes significant variations in MAP, we proposed to study the feasibility of measuring PWV under GA and to investigate its relationship with MAP.
Methods
From December 2022 to February 2023, continuous carotid and femoral Doppler monitoring was performed on patients scheduled for surgery with GA, to collect PWV data at awakening (PWVAW) and during GA (PWVGA). The study investigated PWV's response to MAP fluctuations using the α-angle, a dynamic stiffness parameter. We evaluated PWV and α-angle efficacy in discriminating between low (CVR-) and high (CVR+) cardiovascular risk patients.
Results
Among 43 patients, 41 (95%) had successful PWV measurements. PWVAW was significantly higher than PWVGA (8.1 vs 7.4 m.s-1, p < 0.0001). This difference vanished after matching MAP levels. A strong correlation was found between PWVAW and PWVGA (r = 0.88, and r = 0.97 at the same MAP levels). PWVGA, α-angle and their product (α x PWVGA) were significantly higher in CVR + patients (8.1 vs 6.9 m.s-1, p < 0.01; 2.6 vs 1.3 degrees, p < 0.001; 21.8 vs 8.1 degrees.m.s-1, p < 0.001, respectively), with AUC values indicating good predictive capabilities for cardiovascular risk (PWVGA: AUC [95%CI] = 0.80 [0.65–0.95]; α-angle: 0.83 [0.69–0.96]; product: 0.86 [0.74–0.97]).
Conclusion
Measuring PWV using carotid and femoral Doppler under GA is viable and can discriminate between varying levels of cardiovascular risk. The α-angle offers a promising approach to refining the assessment of arterial stiffness.
Efficacy of Radioiodine in Non-Distant Metastatic Papillary Thyroid Cancer with TERT-p Mutation at Initial Diagnosis
Authors: Deng Xian-Zhao , Liu Meng-yue , Shen Chen-Tian , Song Hong-Jun , Wang JIAN , Fan You-Ben , Luo Quan-yong , Tang Juan , Wei Xiao-er , Qiu Zhong-Ling 
Published: December 2024

Abstract

Background
In patients with non-distant metastatic PTC and TERT-p mutation being a rare entity at initial diagnosis, it is unclear whether 131I treatment is effective and can reduce the risk of recurrence after surgery. The objective of this study was to determine the clinical characteristics, effectiveness of radioiodine (131I), and recurrence-free survival (RFS) in patients with non-distant metastatic papillary thyroid cancer (PTC) and TERT-p mutation at initial diagnosis.
Patients and Methods
A retrospective observational review of clinical data collected between January 2016 and December 2023. One hundred and thirteen patients with non-distant metastatic PTC and TERT-p mutation at initial diagnosis were included.Therapeutic efficacy was evaluated using the dynamic risk stratification. Recurrence-free survival (RFS) was assessed using the Kaplan-Meier method and a Cox proportional hazards model.
Results:
One hundred and thirteen patients were were included.Sixty-two patients (54.9%) received postoperative 131I and 51 (45.1%) did not. There was a significant association between the American Thyroid Association (ATA) risk stratification and whether or not there was an acceptable response at the end of follow-up (p=0.001). There were significant associations of structural disease and TERT-p mutation with extra-thyroidal extension (p=0.003) and ATA risk stratification (p<0.001). Multivariate analyses indicated that age ≥55 years at initial diagnosis, N1b stage, and high-risk stratification were independent prognostic factors for RFS (p=0.014, p=0.003, and p=0.045, respectively).
Conclusions:
131I treatment may have no effect on RFS in patients with non-distant metastatic PTC and TERT-p mutation at initial diagnosis.
Outcomes in patients with acute myeloid leukemia older than 70 years within the last 30 years, a single center experience
Authors: Schulz Felicitas , Roggenbuck Claudia , Kündgen Andrea , Kasprzak Annika , Nachtkamp Kathrin , Jaeger Paul , Dietrich Sascha , Kobbe Guido , Germing Ulrich , Neumann Frank 
Published: December 2024

Abstract

As median age of patients with acute myeloid leukemia is 72 years, older patients continue to be a vulnerable cohort representing significant challenges in clinical practice. Patient-specific comorbidities as well as leukemia-specific unfavorable molecular- and cytogenetics confer even poorer outcomes. Treatment of AML therefore needs to be less toxic to prevent harm while lowering or eradicating leukemic burden to prolong survival. In this retrospective analysis we included all 372 older AML patients from the Düsseldorf registry who were diagnosed and treated in our department of hematology over a period of 25 years. Most patients were treated with HMA (36.6%) followed by 35.5% of patients who received either low dose chemotherapy or BSC. 10% of patients were treated with induction chemotherapy while 8.3% of patients received a combination of HMA with venetoclax. 4% of patients underwent aHSCT. At the time of last follow up, 33 patients (8.9%) were still alive. Of those patients who were treated with induction chemotherapy or HMA + venetoclax, 18.9% and 25.8% were still alive, whereas 60% of the patients who underwent allogeneic stem cell transplantation were still alive (p.<0.001). Median overall survival of the entire patient population was 6 months. Longest survival was observed in patients who underwent aHSCT with an unreached median overall survival followed by patients who were treated with induction chemotherapy (19 months) or HMA plus venetoclax (18 months). The implementation of HMA + venetoclax and increasing numbers of aHSCT improved prognosis and survival even in older AML patients.