bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Manufacturing Variations on Performance of a Transonic Axial Compressor Rotor
Authors: Lejon Marcus , Andersson Niklas , Ellbrant Lars , Mårtensson Hans 
Published: March 2020

Abstract
In this paper, the impact of manufacturing variations on performance of an axial compressor rotor is evaluated at design rotational speed. The geometric variations from the design intent obtained from measurements were used to evaluate the impact of manufacturing variations on performance and the flow field in the rotor. The complete blisk is simulated using 3D computational fluid dynamics calculations, allowing for a detailed analysis of the impact of geometric variations on the flow. It is shown that the mean shift of the geometry from the design intent is responsible for the majority of the change in performance in terms of mass flow and total pressure ratio for this specific blisk. In terms of polytropic efficiency, the measured geometric scatter is shown to have a higher influence than the geometric mean deviation. The geometric scatter around the mean is shown to impact the pressure along the leading edge and the shock position. Furthermore, a blisk is analyzed with one blade deviating substantially from the design intent. It is shown that the impact of this blade on the flow is largely limited to the blade passages that it is directly a part of. It is also shown that the impact of this blade on the flow field can be represented by a simulation including three blade passages. In terms of loss, using five blade passages is shown to give a close estimate for the relative change in loss for the blade deviating substantially from the design intent and for the neighboring blades.
Effect of Post Heat Treatment on the Microstructure and Tensile Properties of Nano TiC Particulate Reinforced Inconel 718 by Selective Laser Melting
Authors: Wang Yachao , Shi Jing 
Published: March 2020

Abstract
To strengthen the metal components by selective laser melting (SLM), adding reinforcement particles and applying post treatments are generally regarded as the two effective means. However, how post heat treatment affects the properties of nano particulate reinforced metal composites obtained by laser additive manufacturing (AM) processes has rarely been studied. In this study, Inconel 718 matrix composite reinforced by 0.5 wt% nano TiC particles was prepared using SLM. To evaluate the effect of the heat treatment routines on the performance of the SLM-produced composite, two levels of solution temperature (980 and 1100 °C) were designed, and the solution treatment was followed by a standard two-step aging (720 °C for 8 h and 620 °C for 8 h). Scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD) observations were performed to examine the microstructure, and transmission electron microscopy (TEM) observation was conducted to characterize the morphologies of incorporated nano particles and precipitated phases. Tensile tests were conducted to evaluate the mechanical properties of the formed composites. It was found that nano particles can effectively strengthen the metal matrix under both as-built and heat-treated conditions, and the material undergoes static recrystallization during the post heat treatment. Also, it was discovered that nano TiC particles play an important role in refining the microstructure of Inconel 718 composite below 980 °C. The maximum tensile strength of 1370 MPa was observed under 980 °C + aging condition, representing a 16% increase as compared with the unreinforced Inconel 718.
Sensorless In-Hand Manipulation by An Underactuated Robot Hand
Authors: Ospina Diego , Ramirez-Serrano Alejandro 
Published: March 2020

Abstract
The limited dexterity that existing hand prostheses provide to users contrasts with the manipulation abilities exhibited by state-of-the-art robot hands. This paper presents an underactuated robot hand with in-hand manipulation capabilities to demonstrate the use of underactuation in the development of effective hand replacements. This paper describes a specific underactuated hand architecture, representative of many existing underactuated hand prototypes. First, the hand is modeled and its ability to manipulate objects of different geometries is analyzed. Second, a manipulation strategy suitable for prosthetic applications is proposed. The strategy enables the hand to manipulate objects in-hand without any a priori information of their geometry or physical properties. Finally, experimental tests conducted to validate the theoretical results are presented.
Risk factors for subretinal fibrosis after anti-VEGF treatment of myopic choroidal neovascularisation
Authors: Xiao Hu , Zhao Xiujuan , Li Songshan , Sun Limei , Xin Wen , Wang Zhirong , Zhang Aiyuan , Zhang Junyan , Ding Xiaoyan 
Published: March 2020

PurposeTo assess the incidence, clinical features and predictive risk factors of subretinal fibrosis after treatment of active myopic choroidal neovascularisation (mCNV) with anti-vascular endothelial growth factor (VEGF).MethodsThis post-hoc analysis of a randomised controlled trial included a total of 54 patients with active mCNV. The clinical data at baseline, month 3 and month 12 were used. Fundus photography and optical coherence tomography at month 3 were used to determine the presence of subretinal fibrosis after anti-VEGF therapy, and its incidence was calculated. Best-corrected visual acuity (BCVA), Visual Function Questionnaire−25 score, macular integrity index (MI) and their changes were compared between eyes with and without subretinal fibrosis. A logistic regression model was used to evaluate the risk factors of subretinal fibrosis.ResultsSubretinal fibrosis occurred in 22 of 54 eyes with mCNV. Patients with subretinal fibrosis achieved similar BCVA improvement in comparison with those without fibrosis at 3 and 12 months after the treatment; however, they had lower visual acuity, more subfoveal CNV (p=0.002), higher CNV thickness at baseline (p=0.016), larger CNV size (p=0.030), larger leakage area (p=0.021) and higher presence of advanced myopic maculopathy (p=0.035). Age <45 years, BCVA <60 ETDRS letters, and MI index <20 at baseline were the predictors for subretinal fibrosis occurrence in a logistic regression model.ConclusionsThe incidence of subretinal fibrosis after anti-VEGF therapy was 40.7% in eyes with mCNV. Age, baseline BCVA and MI index could serve as predictive risk factors of subretinal fibrosis after anti-VEGF treatment in patients with mCNV.
Psychophysiological anxiety response of a rescue helicopter crew in a crane rescue manoeuvre
Authors: Vicente-Rodriguez Marta , Clemente-Suárez V J 
Published: March 2020

BackgroundThis research aimed to analyse the psychophysiological modifications of a rescuer helicopter crew in a crane rescue manoeuvre.MethodsWe analysed in eight participants (32.5±6.6 years) divided in four categories (pilot, mechanic, rescuer and control) with variables of anxiety, rating of perceived exertion (RPE), stress subjective perception (SSP), heart rate, blood oxygen saturation (BOS), skin temperature, blood lactate, cortical arousal, autonomic modulation, legs and hands strength, legs flexibility, spirometry, urine, and short-term memory before and after a helicopter crane rescue manoeuvre.ResultsThe manoeuvre produced a significant (p≤0.05) increment in the RPE, SSP, anxiety, blood lactate and sympathetic modulation, and a decrease in BOS and pulmonary capacity.ConclusionA helicopter rescue crane manoeuvre produced an increase in the sympathetic nervous system modulation, increasing the psychophysiological response of the crew independently of their experience or role. This information allowed us to improve actual specific operative training in this population.
Attitudes of patients and surgeons towards sham surgery trials: a protocol for a scoping review of attributes to inform a discrete choice experiment
Authors: Wall Laura , Hinwood Madeleine , Lang Danielle , Smith Angela , Bunzli Samantha , Clarke Philip , Choong Peter F M , Dowsey Michelle M , Paolucci Francesco 
Published: March 2020

IntroductionIn order to properly evaluate the efficacy of orthopaedic procedures, rigorous, randomised controlled sham surgery trial designs are necessary. However, randomised controlled trials (RCTs) for surgery involving a placebo are ethically debated and difficult to conduct with many failing to reach their desired sample size and power. A review of the literature on barriers and enablers to recruitment, and patient and surgeon attitudes and preferences towards sham surgery trials, will help to determine the characteristics necessary for successful recruitment.Methods and analysisThis review will scope the diverse literature surrounding sham surgery trials with the aim of informing a discrete choice experiment to empirically test patient and surgeon preferences for different sham surgery trial designs. The scoping review will be conducted in accordance with the methodological framework described in Arksey and O’Malley (2005) and reported using the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols extension for Scoping Reviews. The review will be informed by a systematic search of Medline, Embase, PsycInfo, CINAHL and EconLit databases (from database inception to 21 June 2019), a Google Scholar search, and hand searching of reference lists of relevant studies or reviews. Studies or opinion pieces that involve patient, surgeon or trial characteristics, which influence the decision to participate in a trial, will be included. Study selection will be carried out independently by two authors with discrepancies resolved by consensus among three authors. Data will be charted using a standardised form, and results tabulated and narratively summarised with reference to the research questions of the review.Ethics and disseminationThe findings from this review will inform the design of a discrete choice experiment around willingness to participate in surgical trials, the outcomes of which can inform decision and cost-effectiveness models of sham surgery RCTs. The qualitative information from this review will also inform patient-centred outcomes research. The review will be published in a peer-reviewed journal.Trial registration numberCRD42019133296.
Association of intrinsic and extrinsic motivating factors with physician burnout and job satisfaction: a nationwide cross-sectional survey in Taiwan
Authors: Tung Yu-Chi , Chou Ying-Yi , Chang Yu-Hsuan , Chung Kuo-Piao 
Published: March 2020

ObjectiveThe aim of this study was to systematically and simultaneously examine the association of intrinsic and extrinsic motivating factors with physician burnout and job dissatisfaction.DesignA nationally representative survey was fielded from September to November 2017.SettingHospitals and clinics throughout Taiwan.ParticipantsA total of 6674 physicians.Main exposure measureThe main exposure measures were intrinsic motivators (sense of calling, personally rewarding hours per day and meaningful, long-term relationships with patients) and extrinsic motivators (income, work hours, autonomy, and pay-for-performance (P4P) and bundled payment initiatives).Main outcome measuresThe main outcome measures were physician burnout and job dissatisfaction.ResultsA total of 1152 physicians returned the surveys. More sense of calling and personally rewarding hours per day were associated with less physician burnout (OR 0.16, 95% CI 0.10 to 0.26 and OR 0.25, 95% CI 0.13 to 0.47, respectively) and job dissatisfaction (OR 0.35, 95% CI 0.21 to 0.57 and OR 0.46, 95% CI 0.26 to 0.83, respectively). Longer work hours were associated with more physician burnout (OR 2.67, 95% CI 1.54 to 4.63) and job dissatisfaction (OR 1.71, 95% CI 1.05 to 2.79). Not receiving P4P bonuses from their organisations was associated with more physician burnout (OR 1.56, 95% CI 1.02 to 2.38). Not sharing the losses from caring for patients included in the bundled payment system was associated with less physician burnout (OR 0.59, 95% CI 0.36 to 0.97).ConclusionsFostering a healthcare work environment that supports intrinsic motivation and improves work hours may reduce physician burnout and job dissatisfaction. Rewarding physicians fairly and equitably may prevent them from feeling burned out. Value-based care delivery and payment model innovations, such as bundled payments, may encourage healthcare professionals to coordinate care through the standardisation of care to decrease burnout.
Prevalence and associated risk factors of diabetic retinopathy and macular oedema in patients recently diagnosed with type 2 diabetes
Authors: Graue-Hernandez Enrique O , Rivera-De-La-Parra David , Hernandez-Jimenez Sergio , Aguilar-Salinas Carlos A , Kershenobich-Stalnikowitz David , Jimenez-Corona Aida 
Published: March 2020

ObjectiveTo determine the prevalence of diabetic retinopathy (DR) and diabetic macular oedema (DME) and their associated risk factors in patients recently diagnosed with type 2 diabetes.Methods and analysisWe carried out a cross-sectional study from April 2014 to August 2017. We included patients aged ≥18 years. Diabetes was defined as fasting plasma glucose of >7.8 mmol/L or 2-hour postload plasma glucose of >11.1 mmol/L. Non-mydriatic fundus examination with a digital-fundus camera was performed. Three images centred in the macula, optic disc and temporal to the macula were obtained and graded according to the Scottish Scale Classification of Diabetic Retinopathy.Results1232 patients (mean age 51.5 years) with a diabetes duration of 0–5 years were examined. Age-adjusted and sex-adjusted prevalence of DR and DME was 17.4% (95% CI 15.3% to 19.6%) and 6.6% (95% CI 5.4% to 8.2%), respectively. DR was associated with diabetes duration (OR per year=1.20, p<0.001), haemoglobin A1c (HbA1c) from 7.0 to 8.9 (OR=2.19, p<0.001), HbA1c≥9 (OR=2.98, p<0.001) and systolic blood pressure (SBP) (OR=1.16 per 5 mm Hg, p<0.001). DME was associated with diabetes duration (OR per year=1.26, p<0.01), HbA1c from 7.0 to 8.9 (OR=2.26, p<0.05), HbA1c≥9 (OR=2.38, p<0.01), SBP (OR per mm Hg=1.15, p<0.001) and albuminuria (OR=2.45, p<0.01).ConclusionOur study contributes to the evidence of progressive increase in DR and DME risk in early stages of diabetes, supporting the urgent need for early screening.
Armed and prohibited: characteristics of unlawful owners of legally purchased firearms
Authors: Pear Veronica A , McCort Christopher D , Li Yueju , Beckett Laurel , Tancredi Daniel , Studdert David M , Kass Philip H , Pierce Glenn L , Braga Anthony A , Wright Mona A , Laqueur Hannah S , Kravitz-Wirtz Nicole , Wintemute Garen J 
Published: March 2020

BackgroundA substantial proportion of individuals who lawfully purchase firearms later become unlawful owners ('prohibited firearm owners'), usually following events associated with an increased risk for future violence. This high-risk population has not previously been described. We aimed to characterise all individuals in California's Armed and Prohibited Persons System (APPS), a statewide programme for recovering firearms from individuals who legally purchased them and later became prohibited from ownership.MethodsWe used univariate and bivariate statistics to describe and compare prohibited firearm owners in APPS with a random sample of non-prohibited firearm owners in relation to age, sex, race/ethnicity and type of firearms owned as of 1 February 2015. We also characterised the geographical distribution of prohibited firearm owners and described their prohibitions.ResultsOf the 18 976 prohibited firearm owners, most were men (93%), half were white (53%) and the mean age was 47 years. Prohibited firearm owners were more likely to be male and to be black or Hispanic people than non-prohibited owners. Both prohibited and non-prohibited firearm owners had an average of 2.6 firearms, mostly handguns. Nearly half (48%) of prohibited firearm owners had a felony conviction. Extrapolating from our findings, we estimated that there are approximately 100 000 persons in the USA who unlawfully maintained ownership of their firearms following a felony conviction.ConclusionsRetention of firearms among persons who become lawfully prohibited from possessing them is common in California. Given the nationwide dearth of a programme to recover such weapons, this is likely true in other states as well.
Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility
Authors: Martinez Guillaume , Beurois Julie , Dacheux Denis , Cazin Caroline , Bidart Marie , Kherraf Zine-Eddine , Robinson Derrick R , Satre Véronique , Le Gac Gerald , Ka Chandran , Gourlaouen Isabelle , Fichou Yann , Petre Graciane , Dulioust Emmanuel , Zouari Raoudha , Thierry-Mieg Nicolas , Touré Aminata , Arnoult Christophe , Bonhivers Mélanie , Ray Pierre , Coutton Charles 
Published: March 2020

BackgroundMultiple morphological abnormalities of the flagella (MMAF) consistently lead to male infertility due to a reduced or absent sperm motility defined as asthenozoospermia. Despite numerous genes recently described to be recurrently associated with MMAF, more than half of the cases analysed remain unresolved, suggesting that many yet uncharacterised gene defects account for this phenotypeMethodsExome sequencing was performed on 167 infertile men with an MMAF phenotype. Immunostaining and transmission electron microscopy (TEM) in sperm cells from affected individuals were performed to characterise the ultrastructural sperm defects. Gene inactivation using RNA interference (RNAi) was subsequently performed in Trypanosoma.ResultsWe identified six unrelated affected patients carrying a homozygous deleterious variants in MAATS1, a gene encoding CFAP91, a calmodulin-associated and spoke-associated complex (CSC) protein. TEM and immunostaining experiments in sperm cells showed severe central pair complex (CPC) and radial spokes defects. Moreover, we confirmed that the WDR66 protein is a physical and functional partner of CFAP91 into the CSC. Study of Trypanosoma MAATS1’s orthologue (TbCFAP91) highlighted high sequence and structural analogies with the human protein and confirmed the axonemal localisation of the protein. Knockdown of TbCFAP91 using RNAi impaired flagellar movement led to CPC defects in Trypanosoma as observed in humans.ConclusionsWe showed that CFAP91 is essential for normal sperm flagellum structure and function in human and Trypanosoma and that biallelic variants in this gene lead to severe flagellum malformations resulting in astheno-teratozoospermia and primary male infertility.
The illicit cigarette market in six South African townships
Authors: van der Zee Kirsten , Vellios Nicole , van Walbeek Corné , Ross Hana 
Published: March 2020

BackgroundWe estimate the size of the illicit cigarette market in low socioeconomic areas in South Africa before and after a tax increase. In 2018, the real excise tax increased by 3% and the value-added tax (VAT) rate increased from 14% to 15%. Thus, the real tax on cigarettes increased by 4%.MethodsA total of 2427 smokers were interviewed over two rounds of data collection (1234 before the tax increase and 1193 after). Data were collected in six townships across four of South Africa’s nine provinces. Smokers were asked about their most recent cigarette purchase. Cigarettes purchased for R1 (US$0.08) or less per stick are presumed illicit, based on a threshold price, which includes production costs and taxes.ResultsIn 2017 and 2018 respectively, 34.6% and 36.4% of smokers in the sample purchased illicit cigarettes. The increase in the proportion of illicit purchases was not statistically significant. Smokers with relatively low socioeconomic status, those who have low levels of education and those who are older or unemployed are most likely to purchase illicit cigarettes.ConclusionsThe illicit cigarette trade in South African townships is widespread. The government should implement an independent track and trace system to curb tax evasion. This would reduce the availability of illicit cigarettes, improve public health and increase excise tax collection.
Revision of ‘golden hour’ for hemodynamically unstable trauma patients: an analysis of nationwide hospital-based registry in Japan
Authors: Okada Kazuhiro , Matsumoto Hisashi , Saito Nobuyuki , Yagi Takanori , Lee Mihye 
Published: March 2020

BackgroundThe ‘golden hour’ is a well-known concept, suggesting that shortening time from injury to definitive care is critically important for better outcome of trauma patients. However, there was no established evidence to support it. We aimed to validate the association between time to definitive care and mortality in hemodynamically unstable patients for the current trauma care settings.MethodsThe data were collected from the Japan Trauma Data Bank between 2006 and 2015. The inclusion criteria were patients with systolic blood pressure (SBP) <90 mm Hg and heart rate (HR) >110 beats/min or SBP <70 mm Hg who underwent definitive care within 4 hours from the onset of injury and survived for more than 4 hours. The outcome measure was in-hospital mortality. We evaluated the relationship between time to definitive care and mortality using the generalized additive model (GAM). Subgroup analysis was also conducted using GAM after dividing the patients into the severe (SBP <70 mm Hg) and moderate (SBP ≥70 mm Hg and <90 mm Hg, and HR >110 beats/min) shock group.Results1169 patients were enrolled in this study. Of these, 386 (33.0%) died. Median time from injury to definitive care was 137 min. Only 61 patients (5.2%) received definitive care within 60 min. The GAM models demonstrated that mortality remained stable for the early phase, followed by a decrease over time. The severe shock group presented with a paradoxical decline of mortality with time, whereas the moderate shock group had a time-dependent increase in mortality.DiscussionWe did not observe the association of shorter time to definitive care with a decrease in mortality. However, this was likely an offset result of severe and moderate shock groups. The result indicated that early definitive care could have a positive impact on survival outcome of patients with moderate shock.Level of evidenceLevel Ⅳ, prognostic study,
CP-violating Higgs-gauge boson couplings in $$H\nu \bar{\nu }$$ production at three energy stages of CLIC
Authors: Karadeniz O. , Senol A. , Oyulmaz K. Y. , Denizli H. 
Published: March 2020

AbstractA phenomenological study of CP-violating dimension-six operators via the $$e^+e^-\rightarrow \nu \bar{\nu } H$$e+e-→νν¯H process is performed in a model-independent Standard Model effective field theory framework at all energy stages of CLIC using the updated baseline integrated luminosities. All signal and relevant background events are generated in MadGraph and passed through PYTHIA for parton showering and hadronization at parton level. Detector effects are considered via tuned CLIC detector cards in Delphes. Since we reconstruct the Higgs boson from a pair of b-jets, limits on CP-violating dimension-six couplings are obtained at three b-tagging working points: tight, medium and loose defined in the CLIC Delphes card for all three energy stages of CLIC. Our best 95 % C.L. limits at the loose working point (90 % b-tagging efficiency) on $${\tilde{c}}_{HW}$$c~HW and $${\tilde{c}}_{HB}$$c~HB are $$[-7.0\times 10^{-3};7.0\times 10^{-3}]$$[-7.0×10-3;7.0×10-3] and $$[-3.0\times 10^{-2};3.0\times 10^{-2}]$$[-3.0×10-2;3.0×10-2], respectively at the 3 TeV energy stage of CLIC with an integrated luminosity of 5.0 ab$$^{-1}$$-1. Considering a 0.3 % systematic uncertainty from possible experimental sources worsens the limits on these couplings by a factor of two.