bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma
Authors: Wang Zezheng , Zhang Shuang , Pu Yumei , Wang Yuxin , Lin Zitong , Wang Zhiyong 
Published: April 2020

Abstract
Purpose: Surgery for oral cancer with mandibular invasion requires an accurate preoperative assessment. Although cone-beam computed tomography (CBCT), which yields high spatial resolution, is used widely for mandibular examinations, evidence supporting its accuracy for the evaluation of malignant mandibular invasion is insufficient. Therefore, this study aimed to explore the accuracy of CBCT for the preoperative assessment of mandibular invasion. Methods: Thirty mandibular specimens acquired via mandibulectomy for oral squamous cell carcinoma (OSCC) treatment were collected. The excised samples were marked and subjected to CBCT imaging. Hematoxylin–eosin staining was used for histopathological assessment. Mandibular invasion was estimated based on CBCT and pathologic findings. Invasive borders were delineated via histopathological examination and CBCT and merged to compare the extent of invasion. Results: Although CBCT predicted the excised mandible invasion with 100% accuracy, it predicted nerve invasion with only 69.2% accuracy. The bone samples exhibited significant shrinkage (8.9%) due to tissue processing. This bone mass shrinkage led to a tendency of CBCT to underestimate the extent of invasion, with a mean difference of 2.97 mm. Conclusion: CBCT can reliably assess mandibular invasion, but is much less accurate for the estimation of nerve invasion. Given the potential for underestimation of the extent of mandibular invasion, CBCT would be better used to determine the extent of osteotomy.
ADS-B spoofing attack detection method based on LSTM
Authors: Wang Jing , Zou Yunkai , Ding Jianli 
Published: April 2020

Abstract
The open and shared nature of the ADS-B protocol makes its messages extremely vulnerable to various security threats, such as jamming, modification, and injection. This paper proposes an LSTM-based ADS-B spoofing attack detection method from the perspective of data. First, the message sequence is preprocessed in the form of a sliding window, and then a long short-term memory (LSTM) network is used to perform prediction training on the windows. Finally, the residual set of predicted values and true values is calculated to set a threshold. As a result, we can detect a spoofing attack and further identify which feature was attacked. Experiments show that this method can effectively detect 10 different kinds of simulated manipulated ADS-B messages without further increasing the complexity of airborne applications. Therefore, the method can respond well to the security threats suffered by the ADS-B system.
Association between pulse pressure and body mass index in the Chinese adult population in Jilin Province 2013.
Authors: Zhang Min , Li Jingjing , Liu Jinghui , Liu Siyu , Gao Yue , Shen Yuhang , Sun Pinghui 
Published: April 2020

Abstract
Background: Pulse pressure and body mass index were associated with cardiovascular disease, and the relationship of pulse pressure and body mass index exhibited different situation in different study population. We want to access the association among pulse pressure, body mass index, and other factors in different gender Chinese population in Jilin Province. Methods: A multi-stage stratified random cluster sampling method was used to randomly select 3789 residents who without history of taking hypertension medication for questionnaire surveys, physical examinations and laboratory tests. IBM SPSS version 24.0 was used to perform all analysis, and Chi -square test and multinomial logistic regression were applied to analysis data.Results: For males, the multinomial logistic regression analysis shown that overweight was risk factor for other three pulse pressure groups. Besides, the older people(age≥60 years), and hypertension were risk factors for PP3 and PP4. In females results, aged≥45 years, hypertension and waist circumference was risk factor for three higher pulse pressure groups. Body mass index and pulse pressure was no significant association in three pulse pressure groups, and people with higher education level and above were protective factors in the PP3 and PP4 both in males and females.Conclusion: the relationship between body mass index and pulse pressure in different gender displayed different situation, and the association of waist circumference and pulse pressure was stronger than the relationship between body mass index and pulse pressure for women.
Implementation fidelity of Iron and Folic Acid supplementation (IFAs) and associated challenges among pregnant women in Uasin Gishu County Kenya
Authors: Riang'a Roselyter Monchari , Nangulu Anne Kisaka , Broerse Jacqueline E.W. 
Published: April 2020

Abstract
Introduction While Iron and Folic Acid Supplementation (IFAs) policy is offered free of charge in Kenya and has been implemented in Kenya and other low and middle-income-countries for decades, effectiveness of this intervention in improving maternal nutrition status has been inadequate. This study aims to acquire insight into the degree to which IFAs policy guidelines during pregnancy have been implemented as intended and the challenges to implementation fidelity. Methods Data was collected in rural Uasin Gishu County in the western part of Kenya through document analysis, questionnaires among programme recipients (n=188) and semi-structured interviews with programme implementers (n=6). Themes emerging from data are critically discussed using a conceptual framework based on programme theory and the programme implementation fidelity framework. Results Coverage of IFAs is widespread. However, policy content, frequency and participant responsiveness is not fully implemented. Only 10% accessed intervention within the first trimester as recommended by policy guidelines, only 18% and 15% of the respondents received 90 or more iron and folic acid pills respectively during their entire pregnancy period only 28% reported receiving nutritional counselling, and 66% completed taking the IFAs pills that were issued to them. Late initial bookings to antenatal care, drug stock shortage, staff shortage and long queues, confusing dosage instructions, side effects of the pills were established to be the main challenges to effective implementation fidelity. Anticipated health consequences and emphasis by the health officer to take the pills were established to be motivations for adherence to supplements. Conclusions Rather than targeting pregnant women who turn up for care at the health facilities, IFAs interventions should introduce community-based outreach programmes and make use of community-based health workers. This will not only relief the crowded health facilities for effective implementation integrity, but will also reach out to pregnant women within the first trimester when IFAs impact on health is greater and reach out to those women do not turn up at all for interventions at a health facility. Due to shortage and low compliance to IFAs pills, nutritional counselling is vital to promote consumption of locally available micro-nutrient rich food sources.
Post-Cholecystectomy Gall Bladder Remnant and Cystic Duct Stump stone: surgical pitfalls, causes of occurrence and completion cholecystectomy (open versus laparoscopic) as a safe surgical option of treatment: short and long term outcome. Randomized Controlled Clinical Trials.
Authors: alnaimy tamer A , mokhtar Mohammed Mahmoud , Refaat Doaa Omar , Lotfy Mohamed , Osman Gamal , Ibrahim Amr , Metwalli Abd-Elrahman M. , Elshahidy Tamer Mohamed , Riad Mohamed , Sarhan Abd-Elrahman , safwat Khaled , Abdellatif Tarek E. , Abdelhady Waleed A. , Helmy El-Shewy Ali , Abdalla Wael M , Mohamed Hatem , Khalil Osama M.H. , Salah Emad , Orban Yasser A. , Mansour Mohamed Ibrahim , Amr Wesam M. , Mawla Walid A. , mohamed Ahmed Shafik , negm Said mohamed , Wasefy Tamer , Baghdadi Muhammad Ali , Elaidy Mostafa M. , Ahmed Mahmoud Abdou yassin , Sallam Ahmed M. , Habib Fady Mehaney , Goda Ashraf , Abdelhamid Mohamed I. 
Published: April 2020

Abstract
Introduction : cholecystectomy is the standard surgical option of symptomatic gallbladder disease. The symptoms persist after cholecystectomy in 10 - 20% of cases. Residual gall bladder/cystic duct stump stone is one of the most important cause. Aim : to compare between open and laparoscopic completion cholecystectomy for gall bladder (GB) remnant and cystic duct stump stones as regard short and long term outcome.Methods : This study was conducted on 84 cases with residual GB/cystic duct stump stone that were divided into 2 groups, the open completion cholecystectomy group and the laparoscopic completion cholecystectomy group. The diagnosis was made by ultrasound and magnetic resonance cholangio-pancreatography.Results : The mean operative time was 120±13 minutes in open group and 160±10 in laparoscopic group. Blood loss occurred in 8 cases in open group and 2 cases in laparoscopic group that necessitated blood transfusion. Biliary injuries detected intraoperative occurred in 3 cases with open approach and 2 cases with laparoscopic approach and suture immediately by vicryl 3/0. The mean hospital stay was shorter in laparoscopic group than open group. .Conclusion : laparoscopic Completion cholecystectomy is a safe surgical approach for cystic duct stump stone.Research question: is laparoscopic completion cholecystectomy is safe in managing gall bladder and cystic duct stump stones?Hypothesis: laparoscopic completion cholecystectomy is safe in managing gall bladder and cystic duct stump stones.All ethical approval was given by our local Faculty of Medicine ethical committee.Registration at clinicaltrials.gov protocol registration quality control review criteria: NCT04329143 registered in 31 March 2020.retrospective registeredThe work described has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans.
Identification of 10 Important Genes with Poor Prognosis in Non-small cell Lung Cancer through Bioinformatical Analysis
Authors: Wu Wenbin , Fang Cheng , Zhang Chaochao , Hu Nanhua , Wang Lixin 
Published: April 2020

Abstract
Background: The lung cancer has become the most lethal cause of cancer-related death in China and is responsible for more than 1 million deaths all of the world every year, especially non-small cell lung cancer (NSCLC). Although great advance in pharmaceutical therapies for lung cancer patients, the overall survival is still poor. It is necessary to find out the effective biomarkers in order to improve and predict the prognosis of lung cancer patients. The integrated bioinformatical analysis, as a useful tool to dig up the valuable clues, can be applied to search new effective therapeutic targets. Methods: In this work, we utilized four NSCLC datasets (GSE18842, GSE31210, GSE33532 and GSE101929) from Gene Expression Omnibus (GEO) to analyze. We totally found that there were 162 differentially expressed genes (DEGs) in these four datasets, including 41 up-regulated genes and 121 down-regulated genes in NSCLC tissues. The analysis of GO enrichment and KEGG pathway was done by DAVID software. Then, we identified 10 core oncogenes by constructing protein-protein interaction (PPI) network. Last, we further analyzed the 10 core oncogenes through Kaplan Meier plotter online database and Gene Expression Profiling Interactive Analysis (GEPIA) respectively. Results: We discovered 10 key oncogenes which were associated with the progression and poor prognosis for NSCLC, including ANLN, CCNA2, CDCA7, DEPDC1, DLGAP5, HMMR, KIAA0101, RRM2, TOP2A, and UBE2T. Conclusion: These 10 genes can be served as the therapeutic targets and useful prognostic biomarkers for NSCLC treatment.
Cross-cultural adaptation of the Participation and Environment Measure for Children and Youth (PEM-CY) into German: a qualitative study in three countries
Authors: Krieger Beate , Schulze Christina , Boyd Jillian , Amann Ruth , Piškur Barbara , Beurskens Anna , Teplicky Rachel , Moser Albine 
Published: April 2020

Abstract
Background Concepts such as participation and environment may differ across cultures. Consequently, to use a measure like the Participation and Environment Measure for Children and Youth (PEM-CY) in other than the original English-speaking contexts, cultural adaptation needs to be assured. The aim of this study was to cross-culturally translate and adapt the PEM-CY into German as it is used in Germany, Austria and Switzerland. Methods Fifteen parents of children and adolescents with disabilities from three German speaking countries participated in three rounds of think-aloud interviews. We followed the procedure of cultural equivalence guidelines including two additional steps. Data was analyzed by content analysis using semantic, idiomatic, experiential and conceptual equivalence. Results Results show adaptations mainly focused on experiential and conceptual equivalence. Examples of experiential equivalence included adapting the examples of activities in the PEM-CY to reflect typical ones in German speaking countries. Conceptual equivalence mainly addressed aspects of “involvement” and “environment” of children and adolescents and was reached through adaptations such as enhanced instructions and structures, and additional definitions. Conclusion This study presents a cross-cultural translation and adaptation process to develop a German version of the PEM-CY that is suitable for Germany, Austria and Switzerland. As participation and environment are both complex concepts to measure, conceptual equivalence posed the highest challenges for this cultural adaptation. A culturally adapted version of PEM-CY (German) is now available for research, practice and further validation.
Combination of size-exclusion chromatography and ultracentrifugation improves the proteomic profiling of plasma derived small extracellular vesicles
Authors: Wei Rui , Zhao Libo , Kong Guanyi , Liu Xiang , Zhu Shengtao , Zhang Shutian , Min Li 
Published: April 2020

Abstract
Background: Circulating small extracellular vesicles (sEVs) and its associated proteins are of great interest in the early detection of many diseases. However, there is no gold standard for plasma sEVs isolation, especially for proteomic profiling which could be largely affected by contamination such as lipoproteins. Previous studies suggested combinations of different sEVs isolation methods could improve the purity of the isolated fractions. Nevertheless, there is no systematic evaluation of size-exclusion chromatography (SEC), ultracentrifugation (UC) and their combination in a proteomic perspective. Results: Here we exhibited that SEC+UC showed comparable recovery of sEVs with higher purity in contrast to single-step UC or SEC isolation. In our proteomic analysis, there are 992 protein species identified in the sEVs fractions isolated by SEC+UC, much more than the sEVs fractions isolated by UC (453) or SEC (682) alone. As compared to Vesiclepedia and Exocarta databases, SEC+UC kept 584 previously identified sEV-associated proteins and 360 other proteins. Furthermore, detailed analysis suggested that sEV-associated proteins, such as CD9, CD81 and ITGB1, showed the better protein rank in SEC+UC group than UC group and SEC group. Lipoproteins, the most common contamination in sEVs proteomic analysis, along with other free-floating proteins in the plasma, were largely removed in SEC+UC. Conclusions: We suggested that combining SEC with UC could significantly improve the performance of mass-spectrum (MS)-based proteomic profiling in analyzing plasma-derived sEVs.
Teaching of medical science using mother language with bi-lingual approach, an experimental cross over trial
Authors: Alsaid Bayan , Alhimyar Maryam , Naem Antoine , Alasadi Lugien , Alsuliman Tamim 
Published: April 2020

Abstract
Background: Using the mother-tongue language in educational programs increases the students’ comprehension and facilitates the communication with their teachers and instructors. It also prevents linguistic dualism. However, teaching medical sciences in a language other than English remains controversial. The bi-lingual method is using important English terms in context beside the Arabic main text. This study examines the efficiency of using the bi-lingual approach as an alternative educational method that provides the advantages of using the native language and avoids the linguistic barriers when dealing with a foreign environment.Methods: Third-year medical students of the faculty of Medicine of Damascus University were included in a three-week comparative study. They were divided into three groups. Each group attended a 20 minutes' neuroanatomy lecture in three topics using three linguistic methods: Arabic, English or bi-nomenclature. Each lecture with one topic and one linguistic method. Two tests were performed in each lecture (pre- and post-lecture test) with six points as the total score of each test. The participating students had the same pre- and post-lecture test regardless of the used linguistic method. The same professor presented all lectures.Results: A total number of (277) students participated in the study. After excluding all participants who failed to attend the three lectures, the final participants were (147) students The bi-nomenclature method had the highest mean of points: [3.70/6], while the Arabic only method had a mean of [3.19/6] and the English-only method’s mean was [2.76/6]. These results were statistically significant (p-value less than 0.001). It was significant that Arabic questions were answered correctly regardless of the used linguistic method (p-value <0.001).Conclusion: The bi-lingual pedagogic method which combines mother language in the main text and providing of medical terms in both mother langue and English could present suitable medical education strategy in non-English speaking countries.
Relationship between renal biopsy and renal survival in elderly patients with chronic kidney disease: A propensity score matching approach
Authors: Lou Xiaowei , Yuan Shizhu , Shen Wei , Liu Yueming , Jin Juan , Gong Jianguang , Zhao Li , He Qiang , Li Yiwen 
Published: April 2020

Abstract
Background The effect of renal biopsy on the prognosis of elderly patients with chronic kidney disease remains unclear. Thus, in this study, we aimed to evaluate the relationship between renal biopsy and renal survival in this population.Methods In this multi-centre retrospective study, the baseline characteristics among three groups were balanced by propensity matching. All patients were divided into three groups according to age and renal biopsy. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as estimated glomerular filtration rate < 15 mL/min/1.73 m2, dialysis, renal transplantation, or death. The prognostic effects of renal biopsy were evaluated using Cox regression models. Results A total of 1313 patients were identified. After propensity matching, 390 patients were selected and divided into three groups. After a total follow-up period of 55 months, 20 (13.3%) patients (47.6% group 1 vs 7.41% group 2 vs 39.1% group 3) reached renal outcomes. No significant differences were found in renal outcomes among aged patients whether they underwent renal biopsy or not. Cox regression analysis revealed risk factors in aged patients including low albumin and high levels of proteinuria and serum creatinine (P < 0.05). Platelet count was significant only in aged patients who underwent renal biopsy (hazard ratio: 0.642, P < 0.05). Conclusion In conclusion, renal biopsy in the elderly has not shown benefits in terms of renal survival, conservative treatment appears to be a viable therapeutic option in the management of those people.
Evaluation of image quality at the detector’s edge of dedicated breast positron emission tomography: Can small breast cancer near the chest wall be detected ?
Authors: Satoh Yoko , Motosugi Utaroh , Imai Masamichi , Omiya Yoshie , Onishi Hiroshi 
Published: April 2020

Abstract
Purpose : We assessed image quality of dedicated breast positron emission tomography (dbPET) at the detector's edge by phantom and clinical studies.Methods: A breast phantom with four spheres (16, 10, 7.5, and 5 mm in diameter) was filled with 18 F-fluorodeoxyglucose solution of sphere-to-background ratio was 8:1. It was positioned such that the spheres were five different positions from the top edge to the centre of the detector and scanned for 5 min in each position. Reconstructed images were visually evaluated, and % background variability ( %N 5mm ), % contrast ( %Q H ,5mm ), contrast-to-noise ratio ( Q H ,5mm / N 5mm ), and coefficient of variation of the background ( CV background ) were calculated. Next, tumour-to-background ratios (TBRs) between breast cancer near the chest wall (close to the detector’s edge; peripheral group) and at other locations (non-peripheral group) were compared. The TBR of each lesion was also compared between dbPET and PET/computed tomography (CT).Results: As closer to the detector’s edge, the %N 5mm and CV background increased and %Q H ,5mm and Q H ,5mm / N 5mm decreased in the phantom study. The disadvantages of this placement were visually confirmed. With regard to clinical images, TBR of dbPET was significantly higher than that of PET/CT in both the peripheral (12.1±6.2 vs. 6.5±3.4, p =0.0001) and non-peripheral (13.1±7.1 vs. 7.7±7.4, p =0.0004) groups. There was no significant difference in TBR of dbPET between the peripheral and non-peripheral groups (12.1±6.2 vs. 13.1±7.1, p= 0.6367).Conclusion : In the phantom study, the image quality decreased closer to the detector’s edge than at a depth of 1/8. In clinical studies, however, the lesion detectability of dbPET was the same even if the lesion was close to the detector’s edge or not, and it was higher than that in PET/CT. dbPET has a great potential for detecting breast lesions near the chest wall even in young women with small breasts.