bluuebunny/crossref_metadata_2025_split huggingface dataset:
HologLev: Hybrid Magnetic Levitation Platform Integrated with Lensless Holographic Microscopy for Density-Based Cell Analysis
Authors: Delikoyun Kerem , Yaman Sena , Yilmaz Esra , Sarigil Oyku , Anil-Inevi Muge , Ozcivici Engin , Tekin H. Cumhur 
Published: December 2020

AbstractIn clinical practice, a variety of diagnostic applications require the identification of target cells. Density has been used as a physical marker to distinguish cell populations since metabolic activities could alter the cell densities. Magnetic levitation offers a great promise for separating cells at single cell level within heterogeneous populations with respect to cell densities. Traditional magnetic levitation platforms need bulky and precise optical microscopes to visualize levitated cells. Moreover, the evaluation process of cell densities is cumbersome, which also requires trained personnel for operation. In this work, we introduce a device (HologLev) as a fusion of magnetic levitation principle and lensless digital inline holographic microscopy (LDIHM). LDIHM provides ease of use by getting rid of bulky and expensive optics. By placing an imaging sensor just beneath the microcapillary channel without any lenses, recorded holograms are processed for determining cell densities through a fully automated digital image processing scheme. The device costs less than $100 and has a compact design that can fit into a pocket. We perform viability tests the device by levitating three different cell lines (MDA-MB-231, U937, D1 ORL UVA) and comparing them against their dead correspondents. We also tested the differentiation of mouse osteoblastic (7F2) cells by monitoring characteristic variations in their density. Lastly, MDA-MB-231 cells exposed to a chemotherapy drug are separated from original cell lines in our platform. HologLev provides cost-effective, label-free, fully automated cell analysis in a compact design which could be highly desirable for laboratory and point-of-care testing applications.
Concurrent validity of an Estimator of Weekly Alcohol Consumption (EWAC) based on the Extended AUDIT
Authors: Dutey-Magni PF , Brown J , Holmes J , Sinclair JMA 
Published: December 2020

AbstractBackground and AimsThe 3-question Alcohol Use Disorders Identification Test (AUDIT-C) is frequently used in healthcare for screening and brief advice about levels of alcohol consumption. AUDIT-C scores (0–12) provide feedback as categories of risk rather than estimates of actual alcohol intake, an important metric for behaviour change. The study aimed to (a) develop a continuous metric from the Extended AUDIT-C expressed in United Kingdom (UK) units (8g pure ethanol), offering equivalent accuracy, and providing a direct estimator of weekly alcohol consumption (EWAC) and (b) evaluate the EWAC’s bias and error using the Graduated-Frequency (GF) questionnaire as a reference standard of alcohol consumption.DesignCross-sectional diagnostic study based on a nationally-representative survey.SettingsCommunity-dwelling households in England.Participants22,404 household residents aged ≥ 16 years reporting drinking alcohol at least occasionally.MeasurementsComputer-assisted personal interviews consisting of (a) AUDIT questionnaire with extended response items (the ‘Extended AUDIT’) and (b) GF. Primary outcomes were: mean deviation <1 UK unit (metric of bias); root mean squared deviation <2 UK units (metric of total error) between EWAC and GF. The secondary outcome was the receiver operating characteristic area under the curve for predicting alcohol consumption in excess of 14 and 35 UK units.FindingsEWAC had a positive bias of 0.2 UK units [95% confidence interval: 0.08, 0.4] compared with GF. Deviations were skewed: while the mean error was ±11 UK units/week [9.5, 11.9], in half of participants the deviation between EWAC and GF was between 0 and ±2.1 UK units/week. EWAC predicted consumption in excess of 14 UK units/week with a significantly greater area under the curve (0.918 [0.914, 0.923]) than AUDIT-C (0.870 [0.864, 0.876]) or the full AUDIT (0.854 [0.847, 0.860]).ConclusionsA new estimator of weekly alcohol consumption (EWAC), which uses answers to the Extended Alcohol Use Disorders Identification Test (Extended AUDIT-C), meets the targeted bias tolerance. It is superior in accuracy to AUDIT-C and the full AUDIT when predicting consumption thresholds, making it a reliable complement to the Extended AUDIT-C for health promotion interventions.
Validation of molecular clock inferred HIV infection ages: evidence for accurate estimation of infection dates
Authors: Kostaki E. G. , Limnaios S. , Roussos S. , Psichogiou M. , Nikolopoulos G.K. , Friedman S-R. , Antoniadou A. , Chini M. , Hatzakis A. , Sypsa V. , Magiorkinis G. , Seguin-Devaux C. , Paraskevis D. 
Published: December 2020

AbstractImproving HIV diagnosis, access to care and effective antiretroviral treatment provides our global strategy to reduce HIV incidence. To reach this goal we need to increase our knowledge about local epidemics. HIV infection dates would be an important information towards this goal, but they are largely unknown. To date, methods to estimate the dates of HIV infection are based mainly on laboratory or molecular methods. Our aim was to validate molecular clock inferred infection dates that were estimated by analysing sequences from 145 people living with HIV (PLHIV) with known transmission dates (clinically estimated infection dates). All HIV sequences were obtained by Sanger sequencing and were previously found to belong to well-established molecular transmission clusters (MTCs). Our analysis showed that the molecular clock inferred infection dates were correlated with the clinically estimated ones (Spearman’s Correlation coefficient = 0.93, p<0.001) and that there was an agreement between them (Lin’s concordance correlation coefficient = 0.92, p<0.001). For most cases (61.4%), the molecular clock inferred preceded the clinically estimated infection dates. The median difference between clinically and molecularly estimated dates of infection was of 0.18 (IQR: -0.21, 0.89) years. The lowest differences were identified in people who inject drugs of our study population. Our study shows that the estimated time to more recent common ancestor (tMRCA) of nodes within clusters provides a reliable approximation of HIV infections for PLHIV infected within MTCs. Next-generation sequencing data and molecular clock estimates based on heterochronous sequences provide, probably, more reliable methods for inferring infection dates. However, since these data are not available in most of the HIV clinical laboratories, our approach, under specific conditions, can provide a reliable estimation of HIV infection dates and can be used for HIV public health interventions.
Potential role of aberrant mucosal immune response to SARS-CoV-2 in pathogenesis of IgA Nephropathy
Authors: Zhang Zhao , Zhang Guorong , Guo Meng , Tao Wanyin , Liu Xing-Zi , Wei Haiming , Jin Tengchuan , Zhang Yue-Miao , Zhu Shu 
Published: December 2020

AbstractAberrant mucosal immunity has been suggested to play a pivotal role in pathogenesis of IgA nephropathy (IgAN), the most common form of glomerulonephritis worldwide. The outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV-2), the causal pathogen of coronavirus disease 2019 (COVID-19), has become a global concern. However, whether the mucosal immune response caused by SARS-CoV-2 influences the clinical manifestations of IgAN patients remains unknown. Here we tracked the SARS-CoV-2 anti-receptor binding domain (RBD) antibody levels in a cohort of 88 COVID-19 patients. We found that 52.3% of the COVID-19 patients produced more SARS-CoV-2 anti-RBD IgA than IgG or IgM, and the levels of the IgA were stable during 4-41 days of infection. Among these IgA-dominated COVID-19 patients, we found a severe COVID-19 patient concurrent with IgAN. The renal function of the patient declined presenting with increased serum creatinine during the infection and till 7 months post infection. This patient predominantly produced anti-RBD IgA as well as total IgA in the serum compared to that of healthy controls. The analysis of the IgA-coated microbiota as well as proinflammatory cytokine IL-18, which was mainly produced in the intestine, reveals intestinal inflammation, although no obvious gastrointestinal symptom was reported. The mucosal immune responses in the lung are not evaluated due to the lack of samples from respiratory tract. Collectively, our work highlights the potential adverse effect of the mucosal immune response towards SARS-CoV-2, and additional care should be taken for COVID-19 patients with chronic diseases like IgAN.
Financial development, human capital and its impact on economic growth of emerging countries
Authors: Sarwar Aaqib , Khan Muhammad Asif , Sarwar Zahid , Khan Wajid 
Published: December 2020

PurposeThis paper aims to investigate the critical aspect of financial development, human capital and their interactive term on economic growth from the perspective of emerging economies.Design/methodology/approachData set ranged from 2002 to 2017 of 83 emerging countries used in this research and collected from world development indicators of the World Bank. The two-step system generalized method of moments is used to conduct this research within the endogenous growth model while controlling time and country-specific effects.FindingsThe findings of the study indicate that financial development has a positive and significant effect on economic growth. In emerging countries, human capital also has a positive impact on economic growth. Financial development and human capital interactively affect economic growth for emerging economies positively and significantly.Research limitations/implicationsThe data set is limited to 83 emerging countries of the world. The time period for the study is 2002 to 2017.Originality/valueThis research contributes to the existing literature on human capital, financial development and economic growth. Limited research has been conducted on the impact of financial development and human capital on economic growth.
The impact of health information needs' satisfaction of hypertensive patients on their clinical outcomes
Authors: Kostagiolas Petros , Milkas Anastasios , Kourouthanassis Panos , Dimitriadis Kyriakos , Tsioufis Konstantinos , Tousoulis Dimitrios , Niakas Dimitrios 
Published: December 2020

PurposeThe ultimate aim of this study is to investigate how health information needs’ satisfaction actually makes a difference to the patients' management of a chronic clinical condition. The literature falls short of providing evidence on the interaction between patients' health information seeking behaviour and the successful management of a clinical condition. On the other hand, patient education and good information seeking practices are deemed necessary for hypertension management daily decisions.Design/methodology/approachA specially designed questionnaire study was developed: The survey design was informed by the information seeking behaviour model of Wilson for studying hypertension patients' information needs, information resources and obstacles patients face while seeking hypertension-related information. Moreover, clinical information was collected in order to make associations and inference on the impact of information seeking on patients' clinical outcomes.FindingsThe study included 111 patients submitted to the outpatient hypertension clinic of a university hospital in Athens for a 24-h ambulatory blood pressure measurement (ABPM). The analysis showed that those reporting higher satisfaction level of their information needs achieved lower values in ABPM (ABPM<130/80mmHg, p = 0.049). Stepwise the logistic regression analysis revealed three independent factors to predict the possibility of being optimally treated (ABPM<130/80mmHg). Dipping status (OR: 14.052, 95% CI: 4.229–46.688, p = 0.0001) patients with high satisfaction level of their disease (OR: 13.450, 95% CI: 1.364–132.627, p = 0.026) and interpersonal relationships were used as the main source of information (OR: 1.762, 95% CI: 1.024–3.031, p = 0.41).Originality/valueHypertensive patients with high satisfaction level of information achieve better disease control. Among different sources of information, interpersonal relationships emerge as the most appropriate factor for patients' disease control.
Food loss and waste: the new buzzwords. Exploring an evocative holistic 4Es model for firms and consumers
Authors: Fiore Mariantonietta 
Published: December 2020

PurposeEtymologically, the word “loss” means to be deprived, temporarily or permanently, of use of faculty or an advantage. Therefore, when businesses and entrepreneurs suffer large amount of losses, they can be attributed to a non-effective and non-efficient way of handling assets. Consequently, high levels of bad management can be the cause for food losses (FL) across the agri-food supply chain, food waste (FW) depends on consumers' behavior in organizing food basket. Food loss and food waste (FWL) negatively affect environment and global economy. The purpose of this paper is to propose a holistic 4Es (Ethical_Equity_Ecological_Economic) approach aimed at better managing and treating FLW along the agri-food chain from upstream to downstream stages by addressing entrepreneurs and consumers' approach.Design/methodology/approachThe work focuses on the definition and designing of three possible tools: (1) the implementation of a FL_break-even point model; (2) the Hazard Analysis Critical Control Point (HACCP) procedures including a scheme for FL critical points and (3) a consumer's tax FW declaration model. Beginning with these tools, the work tries to define a holistic model by involving all the actors performing in a strictly inter- linked system.FindingsApproaching the FLW issue in a holistic way can ensure the involvement of engaged and productive people at work, lead to strategies and policies aimed at enriching consumers' awareness and entrepreneurs' management approach, and can address the handling of FLW toward Ethical, Equity, Ecological_and Economic (that means effective and efficient) paths.Social implicationsMonitoring and decreasing FLW by implementing the proposed tools from upstream to downstream of the food supply chain can certainly improve the reliability of firm production and investment decisions, and at the same time, behavior of people who feel to be part of an interrelated system. This can help to lighten FLW negative impacts on consumers' income and on pollution as well as indirectly on poverty.Originality/valueThis paper wants to make an innovative attempt to approach the FLW issue in a global and holistic way, while focusing on behavior and awareness of firms/entrepreneurs and consumers/citizens. In addition, the tools and approach defined pave the way for subsequent empirical works to follow.
Effect of work engagement on meaningful work and psychological capital: perspectives from social workers in New Zealand
Authors: Tan Kim-Lim , Lew Tek-Yew , Sim Adriel K.S. 
Published: December 2020

PurposeThis paper investigates the effect and the predictive capacity of work engagement on personal and job resources, in the form of psychological capital (PsyCap) and meaningful work in the non-profit organisations (NPO)s settings.Design/methodology/approachData were collected from 303 social workers working in New Zealand's NPOs. The hypotheses were tested using the partial least squares structural equation modelling (PLS-SEM).FindingsResults of this study reveal that work engagement is positively related to both PsyCap and meaningful work. It shows that work engagement is instrumental in enhancing one's PsyCap at the same time improving one's perception of work. The model demonstrates good predictive power.Originality/valueThis study advances our understanding of the relationship of outcomes to resources as postulated in the JD-R theory. This is the first few studies to examine the effect of work engagement on PsyCap and meaningful work, as well as the mediating effect of PsyCap on the relationship between work engagement and meaningful work. At the same time, it provides conceptual clarity on the role of specific job resource and personal resource, demonstrating that resources do not operate in isolation but can build more resources. This study also contributes to the field of human resource management using a predictive PLS-SEM technique.
An analysis of the scientific literature produced on bank marketing through bibliometrics and scientific mapping – what has been the role of sales in banking?
Authors: Sánchez-Camacho Carlos , Martín-Consuegra David , Carranza Rocío 
Published: December 2020

PurposeThe purpose of this article is to provide an integrated, synthesised overview of the current state of knowledge in the field of bank marketing. This aim prompts us to seek to determine the role of studies on sales within commercial banking literature, to contribute to the flow of new knowledge and to orient both researchers and practitioners with regard to current issues and findings.Design/methodology/approachThis study employs a combined process of bibliometric analysis and scientific mapping using keyword co-occurrence analysis and a representation of relationships by clustering and their longitudinal arrangement. A total of 1,203 articles were analysed using SciMAT.FindingsThe entire conceptual structure of bank marketing is organised into 12 major thematic areas. These are comprised of a set of main topics during each period, changing from one phase to another. The initial periods exhibit less depth in the pursuit of lines of work on bank marketing. The most recent periods show that interest centres on users' acceptance of online and mobile banking, along with the traditional concepts of satisfaction, loyalty and trust. However, it was determined that sales-related topics have never occupied a central role in the bank marketing academic literature.Research limitations/implicationsThis study draws up a scientific map that serves as a guide to perceive what has been done thus far in the area of bank marketing. The detection of specific sub-topics allows for the application of other synthesis techniques, such as meta-analysis. The study's main limitation lies in the difficulty of synthesising all the papers published on bank marketing literature.Originality/valueThe number of disciplines in which bibliometric analyses are used to synthesise and visually portray the whole bodies of scientific literature is increasing. This study maps out the gradual advancement in the field over the years and could serve as a valuable reference for researchers and practitioners interested in bank marketing. Consequently, the conclusions of this retrospective analysis might be considered a summary of its conceptual structure and a comparable foundation for future studies.
Investigating the motivations and constraints of Chinese peer-to-peer accommodation hosts
Authors: Li ShiNa , Fong Lawrence Hoc Nang , Zhang Carol Xiaoyue , Chen Mengxin 
Published: December 2020

PurposeThis paper aims to identify peer-to-peer accommodation hosts’ perceived motivations and constraints, to examine the prediction of the motivation and constraint factors on hosts’ intention to continue business based on hosts’ attitudes and to explore the moderating role of the business scale.Design/methodology/approachA scale for hosts’ perceived motivators and constraints was developed. Mixed methods were used to develop and analyse a conceptual framework for demonstrating how constraints and motivations influence hosts’ behavioural intentions. Findings from interviews with hosts interpretatively supported the survey results.FindingsChinese hosts’ perceived constraints and motivators are identified and explained. The survey results indicate that constraints lower intention to continue one’s business and motivators heightens it. Motivators have a higher effect on attitudes and intentions than constraints do. The business scale was confirmed as a moderator in the constraint–attitude link but not in the motivator–attitude relationship.Practical implicationsThis paper offers policy implications for governments, online platforms and hosts in terms of establishing incentives and solving problems so that Chinese hosts can sustainably operate their businesses.Originality/valueThis paper identifies constraints and motivators and develops a measurement scale for both simultaneously, which provides a holistic explanation of hosts’ attitude and behavioural intention. It also reveals the moderating role of the business scale. In investigating the thoughts of existing hosts operating on global and local platforms in China, this paper complements the literature, which mainly focuses on the Western context and a single global platform.
Cocreating resilient hybrids: the bridging power of social enterprises' organizational logics
Authors: Bonomi Sabrina , Ricciardi Francesca , Rossignoli Cecilia , Zardini Alessandro 
Published: December 2020

PurposeThis study investigates (1) the processes through which social enterprises develop resilient organizational logics and (2) the key resilience factors in the organizational logics of successful social enterprises. The organizational logic is conceptualized here as the dynamic system of roles, rules and social expectations that result from the organization's business model, impact model and organizational form.Design/methodology/approachThis study adopts an inductive approach to identify emerging resilience factors and processes in an exemplary case of social entrepreneurship (a work integration venture). The longitudinal data collection on this case took place from 2011 to 2016, based on approximately 440 h of participant observation and 10 semi-structured interviews.FindingsThe inductive analysis suggests that social enterprises develop resilient organizational logics through multi-level recursive processes of bridging institutional work. These processes enable the development of an organizational logic that is internally robust while linking distant practices, needs and expectations. The authors conceptualize these characteristics into a novel construct, the organizational logic's bridging power, which is operationalizable through two dimensions (hybridity-based and cocreation-based bridging power) and five sub-dimensions.Research limitations/implicationsLike in all inductive studies, further research is needed to validate the proposed model. The new proposed construct “organizational logic's bridging power” is, interestingly, a meta-theoretical concept encouraging cross-fertilization between the literature on institutional logics and that on value cocreation.Originality/valueThe process development model proposed by this study highlights the importance of network-level institutional work for developing cocreation-based resilience. Furthermore, this study shows how institutional theories could be complemented with other bodies of knowledge in order to understand social enterprise resilience.