bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer
Authors: Brunt Adrian Murray , Haviland Joanne S. , Sydenham Mark , Agrawal Rajiv K. , Algurafi Hafiz , Alhasso Abdulla , Barrett-Lee Peter , Bliss Peter , Bloomfield David , Bowen Joanna , Donovan Ellen , Goodman Andy , Harnett Adrian , Hogg Martin , Kumar Sri , Passant Helen , Quigley Mary , Sherwin Liz , Stewart Alan , Syndikus Isabel , Tremlett Jean , Tsang Yat , Venables Karen , Wheatley Duncan , Bliss Judith M. , Yarnold John R. 
Published: July 2020

PURPOSE Previous studies of hypofractionated adjuvant whole-breast radiotherapy for early breast cancer established a 15- or 16-fraction (fr) regimen as standard. The FAST Trial (CRUKE/04/015) evaluated normal tissue effects (NTE) and disease outcomes after 5-fr regimens. Ten-year results are presented. METHODS Women ≥ 50 years of age with low-risk invasive breast carcinoma (pT1-2 pN0) were randomly assigned to 50 Gy/25 fr (5 weeks) or 30 or 28.5 Gy in 5 once-weekly fr of 6.0 or 5.7 Gy. The primary end point was change in photographic breast appearance at 2 and 5 years; secondary end points were physician assessments of NTE and local tumor control. Odds ratios (ORs) from longitudinal analyses compared regimens. RESULTS A total of 915 women were recruited from 18 UK centers (2004-2007). Five-year photographs were available for 615/862 (71%) eligible patients. ORs for change in photographic breast appearance were 1.64 (95% CI, 1.08 to 2.49; P = .019) for 30 Gy and 1.10 (95% CI, 0.70 to 1.71; P = .686) for 28.5 Gy versus 50 Gy. α/β estimate for photographic end point was 2.7 Gy (95% CI, 1.5 to 3.9 Gy), giving a 5-fr schedule of 28 Gy (95% CI, 26 to 30 Gy) estimated to be isoeffective with 50 Gy/25 fr. ORs for any moderate/marked physician-assessed breast NTE (shrinkage, induration, telangiectasia, edema) were 2.12 (95% CI, 1.55 to 2.89; P < .001) for 30 Gy and 1.22 (95% CI, 0.87 to 1.72; P = .248) for 28.5 Gy versus 50 Gy. With 9.9 years median follow-up, 11 ipsilateral breast cancer events (50 Gy: 3; 30 Gy: 4; 28.5 Gy: 4) and 96 deaths (50 Gy: 30; 30 Gy: 33; 28.5 Gy: 33) have occurred. CONCLUSION At 10 years, there was no significant difference in NTE rates after 28.5 Gy/5 fr compared with 50 Gy/25 fr, but NTE were higher after 30 Gy/5 fr. Results confirm the published 3-year findings that a once-weekly 5-fr schedule of whole-breast radiotherapy can be identified that appears to be radiobiologically comparable for NTE to a conventionally fractionated regimen.
Adverse Outcomes Associated With Delaying or Withholding β-Blockers After Cardiac Surgery: A Retrospective Single-Center Cohort Study
Authors: Chanan Emily L. , Kendale Samir M. , Cuff Germaine , Galloway Aubrey C. , Nunnally Mark E. 
Published: July 2020

BACKGROUND:
Ideal timing of postoperative β-blockers is unclear. We hypothesized that patients who do not receive β-blockers immediately after cardiac surgery would have increased in-hospital mortality (primary outcome) and postoperative hemodynamic, pulmonary, neurologic, or respiratory complications (secondary outcomes).

METHODS:
We performed a retrospective cohort study evaluating patients who underwent cardiac surgery at our institution from January 1, 2013 to September 30, 2017. We compared outcomes between patients who received β-blockers by postoperative day (POD) 5 with outcomes in patients who did not receive β-blockers at any time or received them after POD 5. Inverse probability of treatment weighting was used to minimize confounding. Univariate logistic regression analyses were performed on the weighted sets using absent or delayed β-blockers as the independent variable and each outcome as dependent variables in separate analyses. A secondary analysis was performed in patients prescribed preoperative β-blockers. E-values were calculated for significant outcomes.

RESULTS:
All results were confounder adjusted. Among patients presenting for cardiac surgery, not receiving β-blockers by POD 5 or at any time was not associated with the primary outcome in-hospital mortality, estimated odds ratio (OR; 99.5% confidence interval [CI]) of 1.6 (0.49–5.1), P = .28. Not receiving β-blockers by POD 5 or at any time was associated with postoperative atrial fibrillation, estimated OR (99.5% CI) of 1.5 (1.1–2.1), P < .001, and pulmonary complications, estimated OR (99.5% CI) of 3.0 (1.8–5.2), P < .001. E-values were 2.4 for postoperative atrial fibrillation and 5.6 for pulmonary complications. Among patients presenting for cardiac surgery taking preoperative β-blockers, not receiving β-blockers by POD 5 or at any time was not associated with the primary outcome mortality, with estimated OR (99.5% CI) of 1.3 (0.43–4.1), P = .63. In this subset, not receiving β-blockers by POD 5 or at any time was associated with increased adjusted ORs of postoperative atrial fibrillation (OR = 1.6; 99.5% CI, 1.1–2.4; P < .001) and postoperative pulmonary complications (OR = 2.8; 99.5% CI, 1.6–5.2; P < .001). Here, e-values were 2.7 for postoperative atrial fibrillation and 5.1 for pulmonary complications. For the sensitivity analyses for secondary outcomes, exposure and outcome periods overlap. Outcomes may have occurred before or after postoperative β-blocker administration.

CONCLUSIONS:
Among patients who undergo cardiac surgery, not receiving postoperative β-blockers within the first 5 days after cardiac surgery or at any time is not associated with in-hospital mortality and is associated with, but may not necessarily cause, postoperative atrial fibrillation and pulmonary complications.
The kinesin motor Klp98A mediates apical to basal Wg transport
Authors: Witte Leonie , Linnemannstöns Karen , Schmidt Kevin , Honemann-Capito Mona , Grawe Ferdinand , Wodarz Andreas , Gross Julia Christina 
Published: July 2020

ABSTRACT
Development and tissue homeostasis rely on the tight regulation of morphogen secretion. In the Drosophila wing imaginal disc epithelium, Wg secretion for long-range signal transduction occurs after apical Wg entry into the endosomal system, followed by secretory endosomal transport. Although Wg release appears to occur from the apical and basal cell sides, its exact post-endocytic fate and the functional relevance of polarized endosomal Wg trafficking are poorly understood. Here, we identify the kinesin-3 family member Klp98A as the master regulator of intracellular Wg transport after apical endocytosis. In the absence of Klp98A, functional mature endosomes accumulate in the apical cytosol, and endosome transport to the basal cytosol is perturbed. Despite the resulting Wg mislocalization, Wg signal transduction occurs normally. We conclude that transcytosis-independent routes for Wg trafficking exist and demonstrate that Wg can be recycled apically via Rab4-recycling endosomes in the absence of Klp98A.
Unveiling a novel function of CD9 in surface compartmentalization of oocytes
Authors: Inoue Naokazu , Saito Takako , Wada Ikuo 
Published: July 2020

ABSTRACT
Gamete fusion is an indispensable process for bearing offspring. In mammals, sperm IZUMO1–oocyte JUNO recognition essentially carries out the primary step of this process. In oocytes, CD9 is also known to play a crucial role in gamete fusion. In particular, microvilli biogenesis through CD9 involvement appears to be a key event for successful gamete fusion, because CD9-disrupted oocytes produce short and sparse microvillous structures, resulting in almost no fusion ability with spermatozoa. In order to determine how CD9 and JUNO cooperate in gamete fusion, we analyzed the molecular profiles of each molecule in CD9- and JUNO-disrupted oocytes. Consequently, we found that CD9 is crucial for the exclusion of GPI-anchored proteins, such as JUNO and CD55, from the cortical actin cap region, suggesting strict molecular organization of the unique surface of this region. Through distinct surface compartmentalization due to CD9 governing, GPI-anchored proteins are confined to the appropriate fusion site of the oocyte.
Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis
Authors: Ono Kazuya , Sandell Lisa L. , Trainor Paul A. , Wu Doris K. 
Published: July 2020

ABSTRACT
Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (ADHs) or retinol dehydrogenases (RDHs); and oxidation of retinaldehyde into RA by aldehyde dehydrogenases family 1, subfamily A (ALDH1as), such as ALDH1a1, ALDH1a2 and ALDH1a3. Levels of RA in tissues are regulated by spatiotemporal expression patterns of genes encoding RA-synthesizing and -degrading enzymes, such as cytochrome P450 26 (Cyp26 genes). Here, we show that RDH10 is important for both sensory and non-sensory formation of the vestibule of the inner ear. Mice deficient in Rdh10 exhibit failure of utricle-saccule separation, otoconial formation and zonal patterning of vestibular sensory organs. These phenotypes are similar to those of Aldh1a3 knockouts, and the sensory phenotype is complementary to that of Cyp26b1 knockouts. Together, these results demonstrate that RDH10 and ALDH1a3 are the key RA-synthesis enzymes involved in vestibular development. Furthermore, we discovered that RA induces Cyp26b1 expression in the developing vestibular sensory organs, which generates the differential RA signaling required for zonal patterning.
Pex24 and Pex32 are required to tether peroxisomes to the ER for organelle biogenesis, positioning and segregation in yeast
Authors: Wu Fei , de Boer Rinse , Krikken Arjen M. , Akşit Arman , Bordin Nicola , Devos Damien P. , van der Klei Ida J. 
Published: July 2020

ABSTRACT
The yeast Hansenula polymorpha contains four members of the Pex23 family of peroxins, which characteristically contain a DysF domain. Here we show that all four H. polymorpha Pex23 family proteins localize to the endoplasmic reticulum (ER). Pex24 and Pex32, but not Pex23 and Pex29, predominantly accumulate at peroxisome–ER contacts. Upon deletion of PEX24 or PEX32 – and to a much lesser extent, of PEX23 or PEX29 – peroxisome–ER contacts are lost, concomitant with defects in peroxisomal matrix protein import, membrane growth, and organelle proliferation, positioning and segregation. These defects are suppressed by the introduction of an artificial peroxisome–ER tether, indicating that Pex24 and Pex32 contribute to tethering of peroxisomes to the ER. Accumulation of Pex32 at these contact sites is lost in cells lacking the peroxisomal membrane protein Pex11, in conjunction with disruption of the contacts. This indicates that Pex11 contributes to Pex32-dependent peroxisome–ER contact formation. The absence of Pex32 has no major effect on pre-peroxisomal vesicles that occur in pex3 atg1 deletion cells.
Life quality of injured defence forces veterans who play sitting volleyball
Authors: Stamm Raini , Rogenbaum Laura , Stamm Meelis 
Published: July 2020

The purpose of the study was to analyse the life quality and changes in it throughout three different periods in Estonian injured war veterans’ life (before the injury, after the injury and after starting to play sitting volleyball). The main questions the veterans were asked concerned the positive and negative aspects of sitting volleyball, the effect of sitting volleyball on their health and social life, the motivating factors for participating in athletic activities, and whether the rehabilitation process followed the national strategies. The interviewees were nine male injured Estonian Defence Forces war veterans who play sitting volleyball. Veterans’ subjective assessments of life quality were examined with paired samples t-test in SPSS program to find the mean values of veterans’ assessments. The results of the study reveal that it is very important for the disabled to socialise through team sports. The support of family and friends, also setting smaller result-oriented goals help to keep discipline, contribute to a feeling of belonging and self-esteem, and all these help the veterans to get back on track after life-changing injuries. In conclusion, the analysis of the life quality of nine Estonian war veterans revealed that the decrease of mean values after the injury was significant [t = 6.825 (p < 0.001)], and the increase after they started playing sitting volleyball was also significant [t (8) = –8.083 (p < 0.001)].
According to the study, Estonian war veterans found many positive aspects in playing sitting volleyball, which affected their quality of life. The main aspects were team spirit, feeling of usefulness, improvement of balance, physique and health, setting goals and achieving results in sports, sharing their problems with others involved and that other people respected their ability to play instead of looking at their injuries. The most important aspect was better social life. The factors that motivated veterans to continue their rehabilitation were support by family and friends, self-growth, teammates and other injured veterans. The Estonian Defence Forces support veterans thoroughly and introduce them to different sports including sitting volleyball during their rehabilitation. By doing that, the Defence Forces fill the requirements of national strategies to help veterans return to their regular lifestyle. The current study could be helpful for veterans for making better and more informed choices in rehabilitation after the injury and faster return to their desired quality of life. The results could also help to improve the restoration of health and social life. The results are helpful for the development and popularisation of sitting volleyball in Estonia.
Optimising the routing of home health caregivers: can a hybrid ant colony metaheuristic provide a solution?
Authors: Euchi Jalel 
Published: July 2020

Background/Aims Consolidation of a unified health system requires the development of strategies that respond to various existing health needs, thus accommodating new and chronic conditions. Home care is a viable alternative to hospital care to meet the needs of the elderly population as well as those with other conditions that could be managed at home, which leads to a greater demand for home health services. One issue this raises is routing (assigning routes and transport) caregivers, where the goal is to minimise the total cost. Methods A hybrid ant colony algorithm is proposed to solve the problem of routing home health care workers. The algorithm was tested in cases drawn from the literature and compared with works existing in the literature. Results The algorithm provided good quality results with low computation times. Conclusions The comparison results supported the efficacy of the suggested methodology, which can provide decision support for medical managers of home health care.
Review and developments in level 2 psychological support skills training for oncology clinical nurse specialists
Authors: Stevenson Clare , Munro Heather , Barrington Mark 
Published: July 2020

Background/AimsThe need for holistic support to address the psychosocial impact of cancer has featured in NHS recommendations since 2004. This article describes the review, rewrite and evaluation of the North Central and North East London region ‘level 2’ psychological support skills training for oncology clinical nurse specialists.MethodsThe review was conducted in 2016–18; the new training package was then rolled out and evaluated in 2018–19. The re-written training includes models of individualised assessment based on psychological theory, including adjustment and adaptation. It also includes self-care exercises, providing experiential learning for the dual purpose of self-care and as potential material to teach to patients as level 2 interventions. The new training model requires follow-up attendance in clinical discussion groups to consolidate knowledge and skills development. In total, 135 clinical nurse specialists attended over an 18-month period. The evaluation involved pre- and post-training questionnaires.ResultsEvaluation suggests the new training is valued by clinical nurse specialists, is pitched at the right level and increases clinical nurse specialists' subjective ratings of confidence and identification of psychological need, onward referral and self-care.ConclusionsThe new package provides a useful development of the level 2 training model. Future plans are discussed.
Preoperative mental health status is a significant predictor of postoperative outcomes in adolescents treated with hip preservation surgery
Authors: Richard Heather M. , Cerza Shelby P. , De La Rocha Adriana , Podeszwa David A. 
Published: July 2020

Purpose This study was designed to evaluate predictive factors that influence pain, mental health symptoms and postoperative outcomes at six-months post-hip preservation surgery (HPS) in adolescent surgical candidates. Methods In total, 58 HPS candidates (39 female, 19 male; mean age 15.53 years (10 to 19)) were evaluated. Diagnoses included: acetabular dysplasia (34); idiopathic femoroacetabular impingement (15); Perthes disease (six); avascular necrosis (six); and slipped capital femoral epiphysis (six). All patients underwent periacetabular osteotomy (36), surgical hip dislocation (17) or arthroscopy (five). Patients completed the following: Numerical Pain Rating Scale (NPRS); Child Health Questionnaire-87 (CHQ-87); Pediatric Symptom Checklist-Youth (PSC-Y), preoperatively and six months postoperatively. A single psychologist assessed patients in clinics and one to two additional appointments. Results In all, 78% of patients reported one to three years of pain prior to HPS (modified Harris hip score). All pain scores (NPRS) significantly decreased at six months postoperatively. Preoperative mental health scores (CHQ-87) significantly predicted postoperative pain scores (F(1, 57) = 4.07; p < 0.048; R2 = 0.068). Mental health symptoms (PSC-Y) decreased significantly (p < 0.001). Patients who were seen by a psychologist two or more times reported better six-month postoperative outcomes than those seen once: usual pain (NPRS; p = 0.012); patient-reported physical function (CHQ-87; p = 0.029); and mental health (PSC-Y; p = 0.019). HPS patients seen ≥ 60 days prior to surgery showed marked improvements at six months compared with patients seen < 60 days prior to surgery. Conclusion HPS candidates evaluated preoperatively by psychology, as part of an integrated treatment approach, demonstrated statistically significant improvements in pain, health-related quality of life and mental health symptoms. Two+ visits, more than 60 days prior to surgery appears to be impactful. Preoperative pain and mental health symptoms were predictive of postoperative pain. Level of Evidence: II
Dynamic displacement measurement beyond half-wavelength in phase-modulated optical interferometer
Authors: Furukawa Osamu , Takemae Shinya , Tanaka Yosuke 
Published: July 2020

We demonstrate an interference signal-processing method that extends the measurement range of dynamic displacement beyond half the wavelength of light without deteriorating the measurement accuracy in a phase-modulated optical interferometer. The measurement range extension is realized by the algorithm focusing on peak direction of the interference signal waveform. Deterioration of measurement accuracy is avoided by the data processing that removes noisy data sets. Performance of the proposed system is evaluated by the experiments using a pseudo-vibrator composed of a phase modulator. In the experiments using a lead zirconate titanate (PZT) device as a sample, we successfully measure the dynamic displacement of up to 3127 nm, which is larger than the light source wavelength of 1537 nm. Proof-of-principle simulations, including the evaluation of the measurement error, are also conducted, the results of which show that the measurement error of the proposed method is small in principle.
Time-sharing in parental leave: Why and how fathers assess their time to care home alone
Authors: Leitão Mafalda 
Published: July 2020

Abstract
With recent developments, parental leave policies may also be seen as gender equality policies, namely when fathers are given substantial and non-transferable well-paid home-alone time and encouraged by the policies themselves to take it (‘use it or lose it’/extra-time bonuses). Portugal is one of the countries where this type of time was introduced: parents are given an extra well-paid month of main leave after birth (‘initial parental leave’) if each one stays home alone at least 30 days after the other return to work. Given the way it challenges traditional gender roles in family life and in the labour market, a qualitative study was carried out in order to grasp the motives of 24 fathers (non-probability purposive sample) who took this home-alone sharing bonus. Findings reveal that fathers’ motives impact the amount of time they take. From the interactions between two major motivations – care and instrumental – and other social circumstances, such as family negotiation and labour contexts, several time-sharing profiles are identified. Each one making a difference in terms of the amount of time shared by fathers, with those where fathers exceed the one-month bonus-sharing being of particular interest.
Reassessing (de)standardization: Life course trajectories across three generations
Authors: Aboim Sofia , Vasconcelos Pedro 
Published: July 2020

Abstract
A central problem of life course analysis concerns the changes brought about by the pluralization and differentiation of biographies in western societies. Lives would be increasingly dissimilar from each other and marked by a broader range of transitions and stages. Under the lens of life course theorization, the heterogenization of biographies is typically understood as destandardization. However, if the destandardization hypothesis gained momentum, there is still little information about its explanatory power outside the wealthiest centres of Europe and North America. Following recent trends in research, the article critically examines the applicability of the destandardization hypothesis to the Portuguese case. Through an analysis of the lives of three generations of Portuguese men and women, we reconstruct the life trajectories of each generation starting from the 1930s until the early 2000s. Through the reconstitution of both family and work trajectories, we see if there is a standard biography from which to derive subsequent patterns of heterogenization. From this perspective, we reassess the extent to which the destandardization model is suitable for explaining life course transformations in the Portuguese society.
Oral Bile Reinfusion in Chronic Percutaneous Transhepatic Cholangiodrainage
Authors: Kahl Alyssa , Khurana Shruti , Larson Scott 
Published: July 2020

ABSTRACT
Percutaneous transhepatic cholangiodrainage is an intervention for obstructive jaundice that, although effective in decreasing bilirubin levels, often leads to depletion of regular bile acids that subsequently cause malabsorption, diarrhea, and acute kidney injury. Bile reinfusion (BR) is a method of enteral refeeding of biliary secretions to replenish innate bile acids to the patient. In addition, BR is a low-cost alternative to exogenous bile acid replacement and abates the need for inpatient fluid resuscitation. We report oral BR in a patient with percutaneous transhepatic cholangiodrainage due to choledocholithiasis and review the literature on BR.