bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestalt Therapy and Homeorhesis: Evolution with Movement, Discrimination, and Grace
Authors: Resnick Robert W. 
Published: December 2020

ABSTRACTGestalt therapy, the first (mid-1930s) integrative therapy, was both predicated upon and grounded in a world view that privileges human nature as one with the environment: the “organismic/environmental field.” Frederick (Fritz) S. Perls, a Berlin psychoanalyst, utilized this integration to totally reorganize psychotherapy, incorporating ideas and realities from biology, anthropology/sociology, holism, existentialism, phenomenology, psychoanalysis, behaviorism, Gestalt psychology, field theory, Buber, and many other disciplines. His integration has been evolving, distilling, and changing during his lifetime, after his death, and continues today. Theory, like individual character, can become fixed and anachronistic as field conditions change. What is needed is homeorhesis (a return to a trajectory) and not homeostasis (a return to a set point). Many of Perl's “crazy” ideas have been now assimilated by most contemporary psychotherapy models. Still to be widely recognized is that the relevant past is accessible in palpable present transactions (dialogic and others) as it interrupts self-regulation in the present.
La edición de textos sobre Navegación durante los siglos XVI – XVIII: Un apunte histórico
Authors: Pintos Amengual Gabriel 
Published: December 2020

Resumen: En este trabajo, nos proponemos realizar un estudio sobre la producción de textos de Navegación editados durante los siglos XVI al XVIII, periodo en el que se produjo una gran transformación en los métodos empleados en la Navegación. En la que se pasó de realizar una Navegación basada en lo intuitivo y el empirismo hasta llegar a lo especulativo, alcanzando la práctica de la Navegación Científica Astronómica. Pero en este trabajo, no se evalúa la calidad científica de los textos, sólo nos ocupamos de los indicadores que afectan a la producción de los autores, los lugares de edición de los textos y la inter relación que pudieron tener con los hechos relevantes que acompañaron a la formación de los pilotos durante el periodo objeto de este estudio y conocer si estos intervinieron en la producción
Optically and Structurally Stabilized Plasmo‐Bio Interlinking Networks
Authors: Lin Wei‐Kuan , Cui Guangjie , Burns Zachary , Zhao Xintao , Liu Yunbo , Zhang Zhijia , Wang Yi , Ye Xingchen , Park Younggeun , Lee Somin Eunice 
Published: December 2020

AbstractVisualization of dynamic interlinking networks which respond and adapt to the constantly changing environment would be highly beneficial in developing new composite materials and active/responsive materials. Here, optically and structurally stabilized plasmo‐bio interlinking networks (PBINs) free from photobleaching for high resolution, long term visualization are reported. Necessary for structural and optical stability, a new stability algorithm to comprehensively quantify stability and detect minute instability undetectable by traditional methods is introduced. Biocompatible plasmonic gold nanorods (Bio‐AuNRs) are synthesized for high resolution, long term imaging by utilizing bromide‐free alternatives to achieve CTA+ free. Systematic physical, chemical, and biological characterizations reveal the structural and optical stability of Bio‐AuNRs required for constructing PBIN. Lastly, with actin as a model of interlinking networks of the cytoskeleton, optically and structurally stable PBIN (100% CTA+ free, 97% crosslinking rate) in applications as active/responsive materials, are demonstrated.
Reviewing the role of cardiac exosomes in myocardial repair at a glance
Authors: Koohsarian Parisa , Talebi Athar , Rahnama Mahshid A. , Zomorrod Mina S. , Kaviani Saeid , Jalili Arsalan 
Published: December 2020

AbstractExosome‐based therapy is an emerging novel approach for myocardial infarction (MI) treatment. Exosomes are identified as extracellular vesicles that are produced within multivesicular bodies in the cells' cytosols and then are secreted from the cells. Exosomes are 30–100 nm in diameter that are released from viable cells and are different from other secreted vesicles such as apoptotic bodies and microvesicles in their origin and contents such as RNAs, proteins, and nucleic acid. The recent advances in exosome research have demonstrated the role of these bionanovesicles in the physiological, pathological, and molecular aspects of the heart. The results of in vitro and preclinical models have shown that exosomes from different cardiac cells can improve cardiac function following MI. For example, mesenchymal stem cells (MSCs) and cardiac progenitor cells (CPCs) containing exosomes can affect the proliferation, survival, and differentiation of cardiac fibroblasts and cardiomyocytes. Moreover, MSCs‐ and CPCs‐derived exosomes can enhance the migration of endothelial cells. Exosome‐based therapy approaches augment the cardiac function by multiple means, such as reducing fibrosis, stimulation of vascular angiogenesis, and proliferation of cardiomyocytes that result in replacing damaged heart tissue with newly generated functional myocytes. This review article aims to briefly discuss the recent advancements in the role of secreted exosomes in myocardial repair by focusing on cardiac cells‐derived exosomes.
New‐generation anticancer drugs and medication‐related osteonecrosis of the jaw (MRONJ): Late onset 3 years after ipilimumab endovenous administration with a possible role of target therapy
Authors: Guida Agostino , Perri Francesco , Ionna Franco , Ascierto Paolo A. , Grimaldi Antonio M. 
Published: December 2020

AbstractAssociation of immunotherapy and/or chemotherapy and/or targeted therapy, in sequence or as single therapies, may induce osteonecrosis of the jaw. Multidisciplinary team management of these patients should be provided.
Idealized conductance: A new method to evaluate stiffness of trabecular bone
Authors: Feng Chenglong , Yao Jie , Wang Lizhen , Zhang Xizheng , Fan Yubo 
Published: December 2020

AbstractStiffness is an important parameter to evaluate the condition of trabecular bone in biomechanical and clinical research. Microstructural parameters are commonly used to evaluate stiffness, but the accuracy needs to be improved. In this study, the electrical conductance of trabecular bone was calculated based on an idealized condition: trabeculae were electrically conductive and isotropy, other constituents in the trabecular bone were not considered in the simulation. The idealized conductance was calculated to evaluate the stiffness of trabecular bone, and the accuracy was compared with microstructural parameters. Twenty‐one cubic trabecular cubes (5 × 5 × 5 mm3) from three femoral heads were investigated. Microstructural parameters were measured through Micro‐CT scanning. Nominal elastic modulus (E) and idealized conductance (G) of trabecular cubes were measured through micro‐finite element analysis. Bone volume fraction (BV/TV) is the major microstructural parameter that determine the stiffness of trabecular bone. The correlation coefficient between BV/TV and E along three directions were 0.815 (X‐axis), 0.729 (Y‐axis) and 0.914 (Z‐axis). The correlation between G and E were stronger (X‐axis: r = 0.986, Y‐axis: r = 0.986, Z‐axis: r = 0.991). A regression model combining different microstructural parameters was built to evaluate stiffness, but the correlation between them were not significantly improved (X‐axis: r = 0.831, Y‐axis: r = 0.807, Z‐axis: r = 0.905). Compared with microstructural parameters, idealized conductance was a better parameter to evaluate stiffness of trabecular bone.
Weather variation affects the dispersal of grasshoppers beyond their elevational ranges
Authors: Prinster Andrew J. , Resasco Julian , Nufio Cesar R. 
Published: December 2020

Abstract

Understanding how abiotic conditions influence dispersal patterns of organisms is important for understanding the degree to which species can track and persist in the face of changing climate.

The goal of this study was to understand how weather conditions influence the dispersal pattern of multiple nonmigratory grasshopper species from lower elevation grassland habitats in which they complete their life‐cycles to higher elevations that extend beyond their range limits.

Using over a decade of weekly spring to late‐summer field survey data along an elevational gradient, we explored how abundance and richness of dispersing grasshoppers were influenced by temperature, precipitation, and wind speed and direction. We also examined how changes in population sizes at lower elevations might influence these patterns.

We observed that the abundance of dispersing grasshoppers along the gradient declined 4‐fold from the foothills to the subalpine and increased with warmer conditions and when wind flow patterns were mild or in the downslope direction. Thirty‐eight unique grasshopper species from lowland sites were detected as dispersers across the survey years, and warmer years and weak upslope wind conditions also increased the richness of these grasshoppers. The pattern of grasshoppers along the gradient was not sex biased. The positive effect of temperature on dispersal rates was likely explained by an increase in dispersal propensity rather than by an increase in the density of grasshoppers at low elevation sites.

The results of this study support the hypothesis that the dispersal patterns of organisms are influenced by changing climatic conditions themselves and as such, that this context‐dependent dispersal response should be considered when modeling and forecasting the ability of species to respond to climate change.
Super refractory status in a case of Febrile Infection‐Related Epilepsy Syndrome due to hemophagocytic lymphocytic histiocytosis
Authors: Meenakshi‐Sundaram Salvadeeswaran , Sankaranarayanan Muthukani , Jeyaraman Murugan , Ayyappan Chitra , Karthik Somalinga Nagendran , Pandi Suresh 
Published: December 2020

AbstractA 14‐year‐old boy presented with a prodromal respiratory infection followed by super refractory status epilepticus. A diagnosis of Febrile Infection‐Related Epilepsy Syndrome (FIRES) was made. Initial MRI study and CSF analysis were normal. He required multiple anticonvulsants owing to the refractory nature of the seizures. The course of the illness was rather stormy, laced with various medical problems viz. hepatic dysfunction, sepsis, hemodynamic, and hematological abnormalities which posed several challenges in the management. Hemophagocytic lymphocytic histiocytosis (HLH) was identified as the etiology of the illness and was treated but without success. The case report highlights the several immunomodulatory strategies that were employed to treat the disease, despite which the outcome was unfavorable.
Anti‐money laundering regulations and financial sector development
Authors: Ofoeda Isaac , Agbloyor Elikplimi K. , Abor Joshua Y. , Osei Kofi A. 
Published: December 2020

AbstractThis paper is aimed at establishing the effect of anti‐money laundering regulations on financial sector development across the globe. Using data from 2012 to 2018 across 165 economies across different continents, income levels and regulatory environments, we test a number of complex and related hypotheses. (a) We examine the effect of anti‐money laundering regulations on financial sector development. (b) We examine if this effect differs across developing and developed economies. (c) We examine the nonlinearities in the anti‐money laundering regulations‐financial sector development nexus. We use the Prais‐Winsten approach and the panel threshold estimation approaches to test our hypothesized relationships. We find evidence that anti‐money laundering regulations generally promote financial sector development; however, this positive effect is concentrated in developing economies. We also find evidence of threshold effects of anti‐money laundering regulations for our sample. Consistent with the earlier findings, the positive effect of anti‐money laundering regulations on financial development is concentrated in countries below the threshold value of anti‐money laundering regulations. These countries are mostly developing countries. Our findings suggest that strengthening anti‐money laundering regulations will be beneficial to developing countries.
Chemerin/ChemR23 regulates cementoblast function and tooth resorption in mice via inflammatory factors
Authors: Ye Yusi , Fang Lingli , Li Jun , Wu Hongyan , Tan Xi , Luo Hong , Li Xi , Huang Lan 
Published: December 2020

AbstractBackgroundPeriodontitis and orthodontic treatment can lead to inflammatory root resorption (IRR) through an unclear mechanism. Chemerin, a novel chemoattractant protein, is closely associated with inflammation, affects osteoblast and osteoclast differentiation, and may play a role in IRR. We aimed to explore possible roles of the chemerin/ChemR23 interaction in cementoblast function and IRR and reveal a new IRR therapeutic target.MethodsCementoblast function‐related gene and protein expression in the immortalized murine cementoblast cell line OCCM‐30 after treatment with chemerin and siChemR23 was examined by qRT‐PCR and Western blotting. The roles of the MAPK and PI3K‐Akt signaling pathways were studied using specific inhibitors. Cementoblast cytokine production under different treatment conditions was measured by enzyme‐linked immunosorbent assay and qRT‐PCR. Additionally, we modeled IRR in wild‐type and chemerin‐overexpressing mice and injected transgenic mice with anti‐ChemR23 antibody to block ChemR23. We then calculated the root resorption volume and examined periodontal tissue cathepsin K, Runx2, tumor necrosis factor‐α (TNF‐α), and interleukin‐6 (IL‐6) expression.ResultChemerin suppressed cementoblast differentiation and mineralization and exerted a proinflammatory effect on cementoblasts. These effects were partially reversed by siChemR23 and reversed to different extents by p38, Erk1/2 and PI3K‐Akt pathway inhibition, suggesting p38, Erk1/2 and PI3K‐Akt pathways as signaling pathways downstream of chemerin/ChemR23. In vivo, chemerin overexpression worsened IRR. Moreover, chemerin expression was positively correlated with TNF‐α, IL‐6, and cathepsin K expression and negatively correlated with Runx2 expression. ChemR23 downregulation reversed these effects.ConclusionChemerin/ChemR23 induced TNF‐α and IL‐6 expression dependent on Erk1/2, p38 MAPK, and PI3K‐Akt signaling pathway activation, thereby regulating cementoblast function and affecting IRR.
Field investigation on the influence of periglacial processes on pile foundations on the Qinghai–Tibet plateau
Authors: Guo Lei , You Yanhui , Yu Qihao , Shi Zhaoyun , Li Hongbi , Wang Xinbin 
Published: December 2020

AbstractPeriglacial processes can threaten the operation of engineering infrastructure. Based on field observations, the influence of four types of periglacial processes on tower foundations along the Qinghai–Tibet Engineering Corridor were investigated. These periglacial processes change the local thermal and hydraulic processes in soils around the pile foundations, thereby threatening their stability. Frost heaving‐related periglacial phenomena and fast mass wasting are major threats for the operation of pile foundations. The long‐term stability of pile foundations is also threatened by thermokarst‐related periglacial processes and slow mass wasting under the evolving climate change scenario on the Qinghai–Tibet Plateau. Frost weathering has a slight impact on the stability of concrete pile heads, and the long‐term effects of this cannot be ignored. In addition to the impacts of periglacial processes, piles are also affected by engineering problems in areas with shallow artesian ground water, where the use of thermosyphons is associated with frost jacking of the foundations. Further studies are needed on the thermal and hydraulic regimes in soils under the influence of artesian ground water and thermokarst lakes/ponds.
Mesenchymal stromal cells in human immunodeficiency virus-infected patients with discordant immune response: Early results of a phase I/II clinical trial
Authors: Trujillo-Rodríguez María , Viciana Pompeyo , Rivas-Jeremías Inmaculada , Álvarez-Ríos Ana I. , Ruiz-García Antonio , Espinosa-Ibáñez Olga , Arias-Santiago Salvador , Martínez-Atienza Juliana , Mata Rosario , Fernández-López Olga , Ruiz-Mateos Ezequiel , Gutiérrez-Valencia Alicia , López-Cortés Luis F. 
Published: December 2020

Abstract
Between 15% and 30% of HIV-infected subjects fail to increase their CD4+ T-cell counts despite continuous viral suppression (immunological nonresponders [INRs]). These subjects have a higher morbidity and mortality rate, but there are no effective treatments to reverse this situation so far. This study used data from an interrupted phase I/II clinical trial to evaluate safety and immune recovery after INRs were given four infusions, at baseline and at weeks 4, 8, and 20, with human allogeneic mesenchymal stromal cells from adipose tissue (Ad-MSCs). Based on the study design, the first 5 out of 15 INRs recruited received unblinded Ad-MSC infusions. They had a median CD4+ nadir count of 16/μL (range, 2-180) and CD4+ count of 253 cells per microliter (171-412) at baseline after 109 (54-237) months on antiretroviral treatment and 69 (52-91) months of continuous undetectable plasma HIV-RNA. After a year of follow-up, an independent committee recommended the suspension of the study because no increase of CD4+ T-cell counts or CD4+/CD8+ ratios was observed. There were also no significant changes in the phenotype of different immunological lymphocyte subsets, percentages of natural killer cells, regulatory T cells, and dendritic cells, the inflammatory parameters analyzed, and cellular associated HIV-DNA in peripheral blood mononuclear cells. Furthermore, three subjects suffered venous thrombosis events directly related to the Ad-MSC infusions in the arms where the infusions were performed. Although the current study is based on a small sample of participants, the findings suggest that allogeneic Ad-MSC infusions are not effective to improve immune recovery in INR patients or to reduce immune activation or inflammation. ClinicalTrials.gov identifier: NCT0229004. EudraCT number: 2014-000307-26.
Who is obliged when many are involved? Labelled transition system modelling of how obligation arises
Authors: Kulicki Piotr , Trypuz Robert , Sergot Marek 
Published: December 2020

AbstractThe paper tackles the problem of the relation between rights and obligations. Two examples of situations in which such a relation occurs are discussed. One concerns the abortion regulations in Polish law, the other one—a clash between freedom of expression and freedom of enterprise occurring in the context of discrimination. The examples are analysed and formalised using labelled transition systems in the$$n\mathcal {C}+$$nC+framework. Rights are introduced to the system as procedures allowing for their fulfilment. Obligations are based on the requirement of cooperation in the realisation of the goals of the agent that has a right. If the right of an agent cannot be fulfilled without an action of another agent, then that action is obligatory for that agent. If there are many potential contributors who are individually allowed to refuse, then the last of them is obliged to help when all the others have already refused. By means of formalisation this account of the relation under consideration is precisely expressed and shown consistent.
A probabilistic approach to estimating residential losses from different flood types
Authors: Paprotny Dominik , Kreibich Heidi , Morales-Nápoles Oswaldo , Wagenaar Dennis , Castellarin Attilio , Carisi Francesca , Bertin Xavier , Merz Bruno , Schröter Kai 
Published: December 2020

AbstractResidential assets, comprising buildings and household contents, are a major source of direct flood losses. Existing damage models are mostly deterministic and limited to particular countries or flood types. Here, we compile building-level losses from Germany, Italy and the Netherlands covering a wide range of fluvial and pluvial flood events. Utilizing a Bayesian network (BN) for continuous variables, we find that relative losses (i.e. loss relative to exposure) to building structure and its contents could be estimated with five variables: water depth, flow velocity, event return period, building usable floor space area and regional disposable income per capita. The model’s ability to predict flood losses is validated for the 11 flood events contained in the sample. Predictions for the German and Italian fluvial floods were better than for pluvial floods or the 1993 Meuse river flood. Further, a case study of a 2010 coastal flood in France is used to test the BN model’s performance for a type of flood not included in the survey dataset. Overall, the BN model achieved better results than any of 10 alternative damage models for reproducing average losses for the 2010 flood. An additional case study of a 2013 fluvial flood has also shown good performance of the model. The study shows that data from many flood events can be combined to derive most important factors driving flood losses across regions and time, and that resulting damage models could be applied in an open data framework.
How have the European central bank’s monetary policies been affecting financial markets in CEE-3 countries?
Authors: Grabowski Wojciech , Stawasz-Grabowska Ewa 
Published: December 2020

AbstractThis paper aims to contribute to the growing pool of literature on the spillover effects of the European Central Bank’s (un)conventional monetary policies on the exchange rate, sovereign bond and equity markets of the Czech Republic, Hungary and Poland (CEE-3 countries), which are collectively known as the CEE-3 countries. The study is conducted using daily data from January 2010 to September 2019. Our results indicate that the financial markets of the CEE-3 countries have been strongly influenced by the nonstandard measures enacted by the European Central Bank, particularly those involving purchases of euro-area sovereign debt. The strongest spillover effects were identified for the Securities Markets Program, while the effects from the Outright Monetary Transactions program turned out to be the most durable. At the same time, the financial markets of the CEE-3 countries were found to have been largely unaffected by interest rate changes enacted by the European Central Bank.
Interspeaker code-switching use in school-aged bilinguals and its relation with affective factors and language proficiency
Authors: Quirk Erin 
Published: December 2020

AbstractBilingual children may choose to reply to utterances in one language with another language. This behavior, which we call interspeaker code-switching, reportedly varies in frequency across children yet the sources of such variation are not well understood. While its use has been linked to variation in proficiency both concurrently and longitudinally, quantitative analyses of this relationship are limited. Here we measure frequency of interspeaker code-switching in a new population, French–English bilinguals in France (ages 5–8), using parental report and relate it to children’s self-reported language attitudes and perceptions of dominance, English receptive and expressive vocabulary, and sentence repetition ability. These children use interspeaker code-switching infrequently and nearly exclusively in the direction of French. Use is predicted by children’s expressive lexical and grammatical proficiency but not their attitudes toward English and French and exhibits only a marginally significant relationship with self-reported dominance. It shows a closer relationship with proficiency than other more well studied experience variables such as current exposure and output, especially for children with lesser English use. These results support a strong link between interspeaker code-switching and proficiency but not for children’s attitudes in a context where they are generally favorable.