bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does fetal leptin and adiponectin influence children’s lung function and risk of wheeze?
Authors: Ip Blanche C. , Li Nan , Jackson-Browne Medina , Eliot Melissa , Xu Yingying , Chen Aimin , Lanphear Bruce P. , Spanier Adam J. , Braun Joseph M. 
Published: October 2020

AbstractAdipocytokines, which are secreted during fetal development by both mothers and fetuses, may influence fetal lung development, but little human data are available. We used data from the HOME Study to investigate the associations of cord blood adipocytokine concentrations with children’s lung forced expiratory volume (FEV1;N = 160) and their risk of wheeze (N= 281). We measured umbilical cord serum adipocytokine concentrations using enzyme-linked immunosorbent assays and FEV1 using a portable spirometer at ages 4 and 5 to calculate the percent predicted FEV1 (%FEV1). Parents completed standardized questionnaires of their child’s wheeze symptoms every 6 months from birth to age 5, then again at ages 6 and 8. We used multivariable linear mixed models and modified Poisson regression with generalized estimating equations to estimate associations of adipocytokine concentrations (log2-transformed) with children’s %FEV1 and the risk of wheeze, respectively, adjusting for sociodemographic, perinatal, and child factors. Cord serum leptin was not associated with children’s %FEV1. Higher cord serum adiponectin concentrations were associated with higher %FEV1 in girls (β = 3.1, 95% confidence interval [CI]: 0.6, 5.6), but not in boys (β = −1.3, 95% CI: −5.9, 3.3) (sex × adiponectinp-value = 0.05). Higher leptin was associated with lower risk of wheeze in girls (RR = 0.74, 95% CI: 0.66, 0.84), but not boys (RR = 0.87, 95% CI: 0.69, 1.11) (sex × leptinp-value = 0.01). In contrast, higher adiponectin concentrations were associated with lower risk of wheeze (RR = 0.84, 95% CI: 0.73, 0.96) in both boys and girls. These data suggest that fetal adipocytokines may impact lung development and function in early childhood. Future studies are needed to confirm these findings and explore the mechanisms underlying these associations.
Parental Divorce and Interparental Conflict: Spanish Young Adults’ Attachment and Relationship Expectations
Authors: Smith-Etxeberria Klara , Eceiza Amaia , Garneau-Rosner Chelsea , Adler-Baeder Francesca 
Published: October 2020

AbstractThis study focused on the associations between parental divorce and interparental conflict with young adults’ current attachment-related anxiety and avoidance, and romantic relationship expectations. The moderating effect of attachment history was also investigated. Using a sample of 1,078 Spanish young adults (544 women, 518 men; average age 21.4 years), our results confirmed that parental divorce is not associated with young adult children’s higher attachment anxiety and avoidance nor poorer romantic relationship expectations. Moreover, interparental conflict is more strongly associated with attachment-related avoidance (p< .001) and romantic relationship expectations (p< .05) than parental divorce, yet depending on attachment history. In fact, in support of our hypothesis, a more secure attachment history with mother has a buffering effect on the association between high-unresolved interparental conflict and attachment avoidance (β = .17,p< .001). Findings add to the existing literature and promote a better understanding of the complex associations between parental divorce and conflict on adult children´s current attachment and relationship expectations.
Meta-analysis and Scientific Mapping of Well-being and Job Performance
Authors: Gutiérrez Oscar Iván , Polo Jean David , Zambrano Milton José , Molina Diana Carolina 
Published: October 2020

AbstractIn this article, we present a meta-analysis and a scientific mapping about the relationship between different types of well-being and job performance. We followed The PRISMA statement for reporting systematic reviews and meta-analyses (Moher et al., 2009), and conduct the search in Web of Science, SCOPUS, Ebscohost, Proquest, and Jstor databases. We identified 43 studies from 1994 to early 2020 that represent 45 independent samples, 34,221 participants, and 77 correlations between four types of well-being and six of job performance. Meta-analysis results show that are different forms of relations between types and there is not only one form to explain the happy-productive worker hypothesis. The scientific mapping shows that there are seven clusters of topics about well-being and job performance in the Web of Science base articles: (I) Burnout and axiety, (II) Stress and depression, (III) Individual resources, (IV) Work context, (V) Work engagement and commitment, (VI) Justice, and (VII) Human resources practices. We organize the topics from each cluster in the different groups of variables of the contextual model of individual work, well-being and performance (van Veldhoven & Peccei, 2015) to explain their impact in well-being and job performance. We included the observations of our analysis and identified the future key directions for the field.
Gewalterfahrungen und psychische Gesundheit im Verlauf bei unbegleiteten minderjährigen Flüchtlingen in Deutschland
Authors: Müller-Bamouh Veronika , Ruf-Leuschner Martina , Dohrmann Katalin , Elbert Thomas , Schauer Maggie 
Published: October 2020

Zusammenfassung. Hintergrund: Über die seelische Gesundheit von minderjährigen Flüchtlingen, die ohne sorgeberechtigte Person nach Deutschland gereist sind, liegen bisher kaum Daten und keinerlei längsschnittliche Untersuchungen vor. Fragestellung: Ziel ist es daher, die psychische Gesundheit im Zusammenhang mit stressvollen Erfahrungen (insbesondere familiäre und organisierte Gewalterfahrungen) sowie deren Entwicklung nach etwa zwei Jahren bei unbegleiteten minderjährig Geflüchteten in Deutschland zu untersuchen. Methode: In einer Querschnittsstudie wurden belastende Erlebnisse sowie posttraumatische, depressive und psychosomatische Symptome bei 57 unbegleiteten und 22 begleiteten minderjährig eingereisten Flüchtlingen mittels strukturierter klinischer Interviews untersucht. Nach durchschnittlich 20 Monaten wurde eine Subgruppe der unbegleiteten Minderjährigen erneut untersucht. Ergebnisse: Ein Drittel der Teilnehmer erfüllte die Kriterien einer PTBS-Diagnose nach DSM-IV. Nach Einbezug einer Gruppe begleiteter minderjähriger Flüchtlinge zeigte sich, dass vor allem organisierte und familiäre Gewalterfahrungen sowie die Dauer der Flucht bedeutsame Prädiktoren hinsichtlich der PTBS-Symptomschwere waren. Für das psychische Wohlbefinden insgesamt waren die erfahrene Gewalt in der Herkunftsfamilie, bestehende Freundschaften und das Vorhandensein von Privatsphäre relevant. Ergebnisse einer Folgeuntersuchung mit einer Teilgruppe der UMF etwa 20 Monate später zeigten, dass die psychische Beeinträchtigung im Durchschnitt unverändert hoch geblieben war. Fazit: Die Möglichkeit einer frühzeitigen psychischen Untersuchung mit Erfassung kindlicher Gewalterlebnisse sowie ein verbesserter Zugang zu einer traumafokussierten Behandlung mit Sprachmittlern sind wichtig, um Leid zu reduzieren und Integration zu ermöglichen.
Tropical Rainfall Linked to Stronger Future ENSO‐NAO Teleconnection in CMIP5 Models
Authors: Fereday D. R. , Chadwick R. , Knight J. R. , Scaife A. A. 
Published: October 2020

AbstractThe El Niño–Southern Oscillation (ENSO) has previously been shown to influence the winter North Atlantic Oscillation (NAO). Here we investigate the ENSO‐NAO teleconnection in historical and RCP8.5 scenario CMIP5 simulations and show a future strengthening of the teleconnection under RCP8.5. The teleconnection strength is associated with increased East Pacific tropical rainfall variability. Stratospheric and tropospheric teleconnection pathways are examined, with both pathways having stronger links in the future. The stratospheric pathway involves the Aleutian Low and the stratospheric polar vortex with a downward influence on the NAO. This pathway is clearest in the high‐top models that better resolve the stratosphere. The tropospheric pathway is driven by the Pacific subtropical jet strengthening and extending further into the Atlantic in the future, generating increased baroclinicity in the Caribbean and influencing the Atlantic storm track. These results suggest increasing influence of tropical rainfall on extratropical circulation in the future.
Injection‐Induced Seismic Moment Release and Laboratory Fault Slip: Implications for Fluid‐Induced Seismicity
Authors: Wang Lei , Kwiatek Grzegorz , Rybacki Erik , Bohnhoff Marco , Dresen Georg 
Published: October 2020

AbstractUnderstanding the relation between injection‐induced seismic moment release and operational parameters is crucial for early identification of possible seismic hazards associated with fluid‐injection projects. We conducted laboratory fluid‐injection experiments on permeable sandstone samples containing a critically stressed fault at different fluid pressurization rates. The observed fluid‐induced fault deformation is dominantly aseismic. Fluid‐induced stick‐slip and fault creep reveal that total seismic moment release of acoustic emission (AE) events is related to total injected volume, independent of respective fault slip behavior. Seismic moment release rate of AE scales with measured fault slip velocity. For injection‐induced fault slip in a homogeneous pressurized region, released moment shows a linear scaling with injected volume for stable slip (steady slip and fault creep), while we find a cubic relation for dynamic slip. Our results highlight that monitoring evolution of seismic moment release with injected volume in some cases may assist in discriminating between stable slip and unstable runaway ruptures.
Evolution of a Foreshock Bubble in the Midtail Foreshock and Impact on the Magnetopause: 3‐D Global Hybrid Simulation
Authors: Wang Chih‐Ping , Wang Xueyi , Liu Terry Z. , Lin Yu 
Published: October 2020

AbstractForeshock transients have been observed in the midtail foreshock. How a foreshock transient evolves in nightside foreshock and how it may impact the midtail bow shock, magnetosheath, and magnetopause has not been simulated. In this study, we present three‐dimensional global hybrid simulation results of a foreshock bubble (FB) driven by an interplanetary magnetic field (IMF) rotational discontinuity. As the FB propagates in the nightside foreshock, its spatial size grows to >10 RE, and its density and dynamic pressure perturbations are enhanced by >50% of the solar wind values. As the FB interacts with the nightside bow shock, the bow shock is temporarily eroded, and the corresponding dynamic pressure perturbations in the magnetosheath penetrate deep to the magnetopause, causing localized distortion of the magnetopause shape. As the FB moves tailward, it continuously generates new perturbations in the magnetosheath and magnetopause following FB's propagation.
Enhanced Winter Carbon Export Observed by BGC‐Argo in the Northwest Pacific Ocean
Authors: Xing Xiaogang , Wells Mark L. , Chen Shuangling , Lin Sheng , Chai Fei 
Published: October 2020

Key Points

Synoptic‐scale winter blooms and mixed‐layer pump events were observed by a BGC‐Argo float in the midlatitude Northwest Pacific Ocean
The repetitive mixed‐layer pump episodes generated a very high particulate organic carbon export of ~110 mg C m−2 day−1 in wintertime
The current BGC‐Argo protocols captured only 20%, or entirely missed, substantial pulsed carbon export driven by mixed‐layer pump events
Role of Serpentinized Mantle Wedge in Affecting Megathrust Seismogenic Behavior in the Area of the 2010 M = 8.8 Maule Earthquake
Authors: Wang Kelin , Huang Taizi , Tilmann Frederik , Peacock Simon M. , Lange Dietrich 
Published: October 2020

AbstractWhat controls subduction megathrust seismogenesis downdip of the mantle wedge corner (MWC)? We propose that, in the region of the 2010 Mw = 8.8 Maule, Chile, earthquake, serpentine minerals derived from the base of the hydrated mantle wedge exert a dominant control. Based on modeling, we predict that the megathrust fault zone near the MWC contains abundant lizardite/chrysotile‐rich serpentinite that transforms to antigorite‐rich serpentinite at greater depths. From the MWC at 32–40 km depth to at least 55 km, the predominantly velocity‐strengthening megathrust accommodated dynamic propagation of the 2010 rupture but with small slip and negative stress drop. The downdip distribution of interplate aftershocks exhibits a gap around the MWC that can be explained by the velocity‐strengthening behavior of lizardite/chrysotile. Interspersed velocity‐weakening and dynamic weakening antigorite‐rich patches farther downdip may be responsible for increased abundance of aftershocks and possibly for some of the high‐frequency energy radiation during the 2010 rupture.
Enhanced Coastal Shoreline Modeling Using an Ensemble Kalman Filter to Include Nonstationarity in Future Wave Climates
Authors: Ibaceta Raimundo , Splinter Kristen D. , Harley Mitchell D. , Turner Ian L. 
Published: October 2020

AbstractA novel approach to improve seasonal to interannual sandy shoreline predictions is presented, whereby model‐free parameters can vary in time, adjusting to potential nonstationarity in the underlying model forcing. This is achieved by adopting a suitable data assimilation technique (dual state‐parameter ensemble Kalman filter) within the established shoreline evolution model ShoreFor. The method is first tested and evaluated using synthetic scenarios, specifically designed to emulate a broad range of natural sandy shoreline behavior. This approach is then applied to a real‐world shoreline data set, revealing that time‐varying model‐free parameters are linked through physical processes to changing characteristics of the wave forcing. Greater accuracy of shoreline predictions is achieved, compared to existing stationary modeling approaches. It is anticipated that the wider application of this method can improve our understanding and prediction of future beach erosion patterns and trends in a changing wave climate.
Hypoxia and its therapeutic possibilities in paediatric cancers
Authors: Bernauer Carolina , Man Y. K. Stella , Chisholm Julia C. , Lepicard Elise Y. , Robinson Simon P. , Shipley Janet M. 
Published: October 2020

AbstractIn tumours, hypoxia—a condition in which the demand for oxygen is higher than its availability—is well known to be associated with reduced sensitivity to radiotherapy and chemotherapy, and with immunosuppression. The consequences of hypoxia on tumour biology and patient outcomes have therefore led to the investigation of strategies that can alleviate hypoxia in cancer cells, with the aim of sensitising cells to treatments. An alternative therapeutic approach involves the design of prodrugs that are activated by hypoxic cells. Increasing evidence indicates that hypoxia is not just clinically significant in adult cancers but also in paediatric cancers. We evaluate relevant methods to assess the levels and extent of hypoxia in childhood cancers, including novel imaging strategies such as oxygen-enhanced magnetic resonance imaging (MRI). Preclinical and clinical evidence largely supports the use of hypoxia-targeting drugs in children, and we describe the critical need to identify robust predictive biomarkers for the use of such drugs in future paediatric clinical trials. Ultimately, a more personalised approach to treatment that includes targeting hypoxic tumour cells might improve outcomes in subgroups of paediatric cancer patients.
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone
Authors: Lutsik Pavlo , Baude Annika , Mancarella Daniela , Öz Simin , Kühn Alexander , Toth Reka , Hey Joschka , Toprak Umut H. , Lim Jinyeong , Nguyen Viet Ha , Jiang Chao , Mayakonda Anand , Hartmann Mark , Rosemann Felix , Breuer Kersten , Vonficht Dominik , Grünschläger Florian , Lee Suman , Schuhmacher Maren Kirstin , Kusevic Denis , Jauch Anna , Weichenhan Dieter , Zustin Jozef , Schlesner Matthias , Haas Simon , Park Joo Hyun , Park Yoon Jung , Oppermann Udo , Jeltsch Albert , Haller Florian , Fellenberg Jörg , Lindroth Anders M. , Plass Christoph 
Published: October 2020

AbstractThe neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a mutation in H3F3A, leading to a mutant histone variant, H3.3-G34W, as a sole recurrent genetic alteration. We show that in patient-derived stromal cells H3.3-G34W is incorporated into the chromatin and associates with massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone modification level, that can be partially recapitulated in an orthogonal cell line system by the introduction of H3.3-G34W. These epigenetic alterations affect mainly heterochromatic and bivalent regions and provide possible explanations for the genomic instability, as well as the osteolytic phenotype of GCTB. The mutation occurs in differentiating mesenchymal stem cells and associates with an impaired osteogenic differentiation. We propose that the observed epigenetic alterations reflect distinct differentiation stages of H3.3 WT and H3.3 MUT stromal cells and add to H3.3-G34W-associated changes.
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
Authors: Gomez Esteban A. , Colas Romain A. , Souza Patricia R. , Hands Rebecca , Lewis Myles J. , Bessant Conrad , Pitzalis Costantino , Dalli Jesmond 
Published: October 2020

AbstractBiomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving mediator (SPM) concentrations are linked with both DMARD responsiveness and disease pathotype. Machine learning analysis demonstrates that baseline plasma concentrations of resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A4 and n-3 docosapentaenoic-derived Maresin 1 are predictive of DMARD responsiveness at 6 months. Assessment of circulating SPM concentrations 6-months after treatment initiation establishes that differences between responders and non-responders are maintained, with a decrease in SPM concentrations in patients resistant to DMARD therapy. These findings elucidate the potential utility of plasma SPM concentrations as biomarkers of DMARD responsiveness in RA.
Immunizing lithium metal anodes against dendrite growth using protein molecules to achieve high energy batteries
Authors: Wang Tianyi , Li Yanbin , Zhang Jinqiang , Yan Kang , Jaumaux Pauline , Yang Jian , Wang Chengyin , Shanmukaraj Devaraj , Sun Bing , Armand Michel , Cui Yi , Wang Guoxiu 
Published: October 2020

AbstractThe practical applications of lithium metal anodes in high-energy-density lithium metal batteries have been hindered by their formation and growth of lithium dendrites. Herein, we discover that certain protein could efficiently prevent and eliminate the growth of wispy lithium dendrites, leading to long cycle life and high Coulombic efficiency of lithium metal anodes. We contend that the protein molecules function as a “self-defense” agent, mitigating the formation of lithium embryos, thus mimicking natural, pathological immunization mechanisms. When added into the electrolyte, protein molecules are automatically adsorbed on the surface of lithium metal anodes, particularly on the tips of lithium buds, through spatial conformation and secondary structure transformation from α-helix to β-sheets. This effectively changes the electric field distribution around the tips of lithium buds and results in homogeneous plating and stripping of lithium metal anodes. Furthermore, we develop a slow sustained-release strategy to overcome the limited dispersibility of protein in the ether-based electrolyte and achieve a remarkably enhanced cycling performance of more than 2000 cycles for lithium metal batteries.
A spatial-temporal continuous dataset of the transpiration to evapotranspiration ratio in China from 1981–2015
Authors: Niu Zhongen , He Honglin , Zhu Gaofeng , Ren Xiaoli , Zhang Li , Zhang Kun 
Published: October 2020

AbstractThe ratio of plant transpiration to total terrestrial evapotranspiration (T/ET) captures the role of vegetation in surface-atmosphere interactions. However, several studies have documented a large variability in T/ET. In this paper, we present a new T/ET dataset (also including transpiration, evapotranspiration data) for China from 1981 to 2015 with spatial and temporal resolutions of 0.05° and 8 days, respectively. The T/ET dataset is based on a model-data fusion method that integrates the Priestley-Taylor Jet Propulsion Laboratory (PT-JPL) model with multivariate observational datasets (transpiration and evapotranspiration). The dataset is driven by satellite-based leaf area index (LAI) data from GLASS and GLOBMAP, and climate data from the Chinese Ecosystem Research Network (CERN). Observational annual T/ET were used to validate the model, withR2and RMSE values were 0.73 and 0.07 (12.41%), respectively. The dataset provides significant insight into T/ET and its changes over the Chinese terrestrial ecosystem and will be beneficial for understanding the hydrological cycle and energy budgets between the land and the atmosphere.
Significance of Hall effect and Ion slip in a three-dimensional bioconvective Tangent hyperbolic nanofluid flow subject to Arrhenius activation energy
Authors: Ramzan Muhammad , Gul Hina , Chung Jae Dong , Kadry Seifedine , Chu Yu-Ming 
Published: October 2020

AbstractThe dynamics of partially ionized fluid flow subjected to the magnetic field are altogether distinct in comparison to the flow of natural fluids. Fewer studies are available in the literature discussing the alluring characteristics of the Hall effect and the Ion slip in nanofluid flows. Nevertheless, the flow of nanofluid flow with Hall and Ion slip effect integrated with activation energy, gyrotactic microorganisms, and Cattaneo–Christov heat flux is still scarce. To fill in this gap, our aim here is to examine the three dimensional electrically conducting Tangent hyperbolic bioconvective nanofluid flow with Hall and Ion slip under the influence of magnetic field and heat transmission phenomenon past a stretching sheet. Impacts of Cattaneo–Christov heat flux, Arrhenius activation energy, and chemical reaction are also considered here. For the conversion of a non-linear system to an ordinary one, pertinent transformations procedure is implemented. By using the bvp4c MATLAB function, these equations with the boundary conditions are worked out numerically. The significant impacts of prominent parameters on velocity, temperature, and concentration profiles are investigated through graphical illustrations. The results show that the velocity of the fluid is enhanced once the Ion slip and Hall parameters values are improved. Furthermore, the concentration is improved when the values of the activation energy parameter are enhanced.