bluuebunny/crossref_metadata_2025_split huggingface dataset:
HN1L promotes migration and invasion of breast cancer by up‐regulating the expression of HMGB1
Authors: Jiao Dechuang , Zhang Jingyang , Chen Ping , Guo Xuhui , Qiao Jianghua , Zhu Jiujun , Wang Lina , Lu Zhenduo , Liu Zhenzhen 
Published: November 2020

AbstractRecent reports showed that haematological and neurological expressed 1‐like (HN1L) gene participated in tumorigenesis and tumour invasion. However, the expression and role of HN1L in breast cancer remain to be investigated. Here, bioinformatics, western blot and immunohistochemistry were used to detect the expression of HN1L in breast cancer. Wound healing, transwell assay, immunofluorescence assay and mass spectrum were used to explore the role and mechanism of HN1L on the migration and invasion of breast cancer, which was confirmed in vivo using a nude mice model. Results showed that HN1L was significantly over‐expressed in breast cancer tissues, which was positively correlated with M metastasis of breast cancer patients. Silencing HN1L significantly inhibited the invasion and metastasis of breast cancer cells in vitro and lung metastasis in nude mice metastasis model of breast cancer. Mechanistically, HN1L interacted with HSPA9 and affected the expression of HMGB1, playing a key role in promoting the invasion and metastasis of breast cancer cell. These results suggested that HN1L was an appealing drug target for breast cancer.
Mitigating flood risk using low‐cost sensors and citizen science: A proof‐of‐concept study from western Nepal
Authors: Pandeya Bhopal , Uprety Madhab , Paul Jonathan D. , Sharma Rishi Ram , Dugar Sumit , Buytaert Wouter 
Published: November 2020

AbstractThe generation of hydrological data for accurate flood predictions requires robust and, ideally, dense monitoring systems. This requirement is challenging in locations such as the Himalayas, which are characterised by unpredictable hydroclimatic behaviour with dramatic small‐scale spatial and temporal variability. River level monitoring sensors that are affordable and easy‐to‐operate could support flood risk management activities in the region. We therefore identify potential for a local participatory monitoring network that also serve to overcome existing data gaps, which represent the main bottleneck for establishing an effective community‐based flood early‐warning system. We have applied a citizen science‐based hydrological monitoring approach in which we tested low‐cost river level sensors. Initial results, collected over summer 2017 from two stations on the River Karnali, suggest that our system can successfully be operated by non‐scientists, producing river level data that match those obtained from an adjacent government‐operated high‐tech radar sensor. We discuss potential opportunities to integrate these low‐cost sensors into existing hydrological monitoring practice. Combined with an adaptive, community‐led approach to resilience building, we argue that our low‐cost sensing technology has the potential not only to increase spatial network coverage in data‐scarce regions, but also to empower and educate local stakeholders to build flood resilience.
Long reach of the NAAG family tree
Authors: Williams Steve , Rae Caroline D. 
Published: November 2020

AbstractThe last common ancestor of humans and fruit flies lived about 800 million years ago, yet both of us have nervous systems that share a number of common important features, for example the use of glutamate as a neurotransmitter. We can now possibly add another common feature to the neural tissue of humans and fruit flies which is that of N‐acetylaspartylglutamate (NAAG) peptides. This Editorial highlights an article by Kozik and coworkers in the current issue of the Journal of Neurochemistry, in which the authors report the discovery, in Drosophila melanogaster nervous system, of NAA‐glutamylglutamate (NAAG2).
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Clinical and Patient‐Reported Outcomes of Single Posterior Implant‐Supported Restorations Completed by Predoctoral Students: A Retrospective Study with Up to 10 Years of Follow Up
Authors: Bompolaki Despoina , Edmondson Sara A. , Katancik James A. , Kamposiora Phophi , Papavasiliou George 
Published: November 2020

AbstractPurposeTo assess clinical outcomes of screw‐retained implant‐supported restorations as well as patient satisfaction and Oral Health‐related Quality of Life (OHQoL), when treatment is performed in an academic setting by supervised predoctoral students.Materials and methodsNinety patients (n = 129 restorations) consented to participate in the study. The mean follow‐up period was 4.2 years (range: 4 months to 10.6 years) after crown insertion. All patients filled out a modified Oral Health Impact Profile questionnaire, consisting of 14 questions (OHIP‐14). A comprehensive examination of the implant‐supported restoration was completed and restorative complications were recorded. Statistical analysis was performed using SPSS (IBM SPSS Statistics, v25; IBM Corp). Restoration survival rates were calculated using Kaplan‐Meier survival analysis.ResultsThe most frequent complication was loss of the mesial interproximal contact (32.2%). The overall restoration survival and success rates were 93.8% and 74.4%, respectively. The majority of patients (95.6%) reported high satisfaction with their decision to get implant treatment in the predoctoral clinic.ConclusionsIn the context of this study, clinical and patient‐based outcomes of implant treatment rendered in an academic setting are favorable and comparable to those reported in the literature for restorations completed by experienced dentists.
A Novel Approach for Converting a Mandibular Complete Denture to a Fixed Interim, Screw‐Retained Implant Prostheses: A Case Report
Authors: Kofford Brandon , Drago Carl , Nejat Amir Hossein , Elshewy Mohamed 
Published: November 2020

AbstractFor most of the last century, conventional complete dentures have been the standard of care and the most common treatment for edentulous patients. Technological advancements in fabrication techniques may significantly reduce the number of office visits required to fabricate complete dentures. Immediate occlusal loading with mandibular full arch prostheses has been extensively researched and is now one of the standards of care for edentulous patients. A clinical technique for converting a mandibular immediate complete denture to an interim full arch, screw‐retained fixed prosthesis with novel implant restorative components for immediate loading on four implants is described.
Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection—Pilot study
Authors: Teraoka Yuji , Imamura Michio , Uchida Takuro , Ohya Kazuki , Morio Kei , Fujino Hatsue , Ono Atsushi , Nakahara Takashi , Murakami Eisuke , Yamauchi Masami , Kawaoka Tomokazu , Miki Daiki , Tsuge Masataka , Hiramatsu Akira , Abe‐Chayama Hiromi , Nelson Hayes C. , Aikata Hiroshi , Chayama Kazuaki 
Published: November 2020

AbstractAlthough glucocorticoids have been used for immunosuppression of patients with primary hepatitis B virus (HBV) infection‐induced severe hepatitis, the treatment is associated with a high frequency of adverse events. We conducted a pilot study for evaluating the efficacy and safety of abatacept, a cytotoxic T lymphocyte antigen‐4 immunoglobulin (CTLA4), for acute hepatitis B. Five patients with severe acute hepatitis B (prothrombin activity ≤ 60%) were treated for immunosuppression by abatacept. Four patients received abatacept concurrently with methylprednisolone, and another patient was treated with abatacept alone. Rapid decrease in serum alanine aminotransferase levels, increase in prothrombin activity and improvement of general condition were obtained in four out of five patients. The patient with the most severe hepatitis underwent liver transplantation due to exacerbation of hepatitis in spite of treatment with both abatacept and methylprednisolone. None of the patients developed significant adverse events associated with the use of abatacept. Hepatitis B surface antigen (HBsAg) became negative in all five patients. The effect of abatacept and methylprednisolone for severe hepatitis B was compared using a mouse model. Rapid reduction in mouse serum HBV DNA and human albumin levels and elevation of serum interferon‐gamma and granzyme A levels were observed in HBV‐infected human hepatocyte‐transplanted immunodeficient mice that were administered human peripheral blood mononuclear cells. These hepatocyte injuries were inhibited to a greater extent by abatacept compared to methylprednisolone. Abatacept might be an effective therapy alternative to methylprednisolone to reduce acute massive liver damage for patients with severe acute hepatitis caused by HBV infection.
Effects of Multimedia versus Live Professional Development on Teachers’ and Students’ Performance Related to the Question Exploration Routine
Authors: Schumaker Jean B. , Fisher Joseph B. , Walsh Lisa D. , Lancaster Paula E. 
Published: November 2020

AbstractIn each of two studies, teachers were randomly assigned to either a Virtual Workshop (VW) group that used a computerized professional development program or an Actual Workshop (AW) group that participated in face‐to‐face professional development, including discussion, feedback, and collaboration. In both studies, teachers’ posttest scores related to their knowledge of the Question Exploration Routine and their plans for using it were significantly higher than their pretest scores. In Study 2, both groups’ posttest scores with regard to implementation and planning of the routine were significantly greater than their pretest scores. There were no significant differences between the groups at posttesting on any measure. The posttest knowledge scores of the whole groups of students and the subgroups of students with LD being taught by both groups of teachers were significantly higher than their pretest scores. All teachers indicated that they were satisfied with the training and the routine. VW teachers in both studies indicated that they were satisfied with the software program.
UV laser‐induced fluorescence spectroscopy as a non‐destructive technique for mineral and organic detection in carbonaceous chondrites
Authors: Lymer Elizabeth A. , Daly Michael G. , Tait Kimberly T. , Di cecco Veronica E. , Lalla Emmanuel A. 
Published: November 2020

AbstractHere, we discuss the merits of non‐destructive UV laser‐induced fluorescence spectroscopy (LIF) as a flight or laboratory instrument to analyze organic and mineral material in samples on or returned from carbon‐rich asteroids such as (101955) Bennu by NASA’s OSIRIS‐REx mission. LIF is a unique instrument that is non‐destructive while acquiring data, and allows for no sample preparation, crushing, or cutting. This method provides spectral data indicative of specific minerals and organics in less time than Raman spectroscopy, and can be set up to produce 2‐D raster images of areas of interest. Furthermore, if an LIF system is set up with a gated CCD camera, time‐resolved fluorescence spectroscopy can be performed, providing a unique identification tool for organic and mineral contents using fluorescence decay over several nanoseconds. This technique was used to analyze millimeter‐sized chondrules and calcium‐aluminum‐rich inclusions on four carbonaceous chondrite samples provided by the Royal Ontario Museum: Murchison (CM2), Allende (CV3), NWA 11554 (CV3), and NWA 12796 (CK3). The LIF 2‐D maps, point spectra, and time‐resolved fluorescence data and mineral identifications using LIF were compared to that of well‐known techniques such as Raman spectroscopy and SEM/EDS.
Root effects on soil organic carbon: a double‐edged sword
Authors: Dijkstra Feike A. , Zhu Biao , Cheng Weixin 
Published: November 2020

SummaryFrom recent developments on how roots affect soil organic carbon (SOC) an apparent paradox has emerged where roots drive SOC stabilization causing SOC accrual, but also SOC destabilization causing SOC loss. We synthesize current results and propose the new Rhizo‐Engine framework consisting of two linked components: microbial turnover and the soil physicochemical matrix. The Rhizo‐Engine is driven by rhizodeposition, root turnover, and plant uptake of nutrients and water, thereby accelerating SOC turnover through both stabilization and destabilization mechanisms. This Rhizo‐Engine framework emphasizes the need for a more holistic approach to study root‐driven SOC dynamics. This framework would provide better understanding of plant root effects on soil carbon sequestration and the sensitivity of SOC stocks to climate and land‐use changes.
Guidelines for Cancer‐Related Pain: A Systematic Review of Complementary and Alternative Medicine Recommendations
Authors: Ng Jeremy Y. , Sharma Alisha E. 
Published: November 2020

AbstractBackground and ObjectiveAlthough up to 85% of patients with cancer use complementary and alternative medicine (CAM), they commonly do not disclose this information to their healthcare providers. Cancer‐related pain (CRP) is one of the most common symptoms among those who may seek CAM. This study was conducted to identify the quantity and assess the quality of CAM recommendations across clinical practice guidelines (CPGs) for the treatment and/or management of CRP, as this has not been explored in the literature.MethodsA systematic review was conducted to identify cancer pain CPGs. MEDLINE, EMBASE, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched from 2009 to 2020. The Guideline International Network and the National Centre for Complementary and Integrative Health websites were also searched. Eligible CPGs on CRP in adults were assessed using the Appraisal of Guidelines, Research and Evaluation II (AGREE II) instrument.ResultsOf 771 unique search results, 13 mentioned CAM and 11 made CAM recommendations. Eligible CPGs were published in 2009 or later and focused on the treatment/management of CRP. Scaled domain percentages from highest to lowest ranged from (overall, CAM): 88.1%, 88.1% (for scope and purpose) to 21.0%, 8.5% (for applicability). Quality varied within and across CPGs. One CPG was recommended by both appraisers; 6 were recommended as “Yes” or “Yes with modifications.”ConclusionsThe present study has identified and summarized a number of CPGs that clinicians may consult to understand what CAMs are recommended in the context of the treatment and/or management of CRP.
Both sides of the story: Narratives of romantic infidelity
Authors: Wilkinson Dulce E. , Dunlop William L. 
Published: November 2020

AbstractWe applied a narrative identity approach to the study of romantic infidelity. In Study 1, participants provided narratives of the moment they discovered their partners' infidelity. In Study 2, participants were prompted for narratives of their unfaithful actions. In both studies, measures of personality traits, forgiveness, empathy, and self‐esteem were administered. Narratives were coded for themes of redemption (bad beginnings, positive endings) and exploration (engaging with the experience's emotional implications). After controlling for relevant covariates (e.g., story length), participants who formed redemptive stories of their partner's infidelity evinced higher levels of forgiveness and lower levels of empathy (Study 1), whereas participants who disclosed redemptive stories about their own infidelity demonstrated decreased forgiveness (Study 2). Across studies, exploratory narratives corresponded positively with conscientiousness.
Collective Complaint: Immigrant Women Caregivers’ Community, Performance, and the Limits of Labor Law in New York City
Authors: Glaser Alana Lee 
Published: November 2020

AbstractIn 2010 New York passed the first legal protections for in‐home care workers in the United States. Amid these legal changes, care workers deploy collective complaint as a community‐building strategy, allowing immigrant women who are domestic workers—often isolated in private homes—to commiserate with one another through shared criticisms of their, mostly women, employers. Based on fieldwork among activist nannies in New York between 2010 and 2012, I argue that collective complaint is a critical source of solidarity and community for childcare providers while caregivers’ rhetorical and affective strategies offer insight about the potential limitations of rights‐based legislation in this and other informal sectors.
An Authoritarian Undercurrent in the Postmaterialist Tide: The Rise of Authoritarianism Among the Younger Generation in China
Authors: Jin Shuai , Zhou Yingnan Joseph 
Published: November 2020

ObjectiveThis study examines how the political context of socialization affects the political orientations of the younger generation in China.MethodsUsing four national surveys and multiple indicators of authoritarian orientation, this study compares Chinese generations with multilevel ordered logistic regression and linear regression.ResultsOur analysis shows that the younger generation, Xi generation, is more orientated toward authoritarianism than its preceding generations, while its previous generation, Hu generation, was not more authoritarian than its prior generations when the Hu generation was the youngest in the survey.ConclusionAgainst the influential modernization theory, which predicts young generations to be more critical of the status quo, we conclude that the younger generation in China is on the authoritarian side of the spectrum and this generational pattern is more likely to be caused by heightened authoritarianism in the political context of socialization than a life‐cycle effect.
Altered prolactin and androgen receptors expression in companion rat benign mammary tumours
Authors: Vergneau‐Grosset Claire , Cluzel Caroline , Beauchamp Guy , Hubbard Neil E. , Paul‐Murphy Joanne , Paquet Marilène 
Published: November 2020

AbstractBenign mammary tumours are among the most common tumours of companion rats (Rattus norvegicus domestica), as well as a major animal welfare concern and euthanasia. The first objective of this study was to evaluate the expression of oestrogen, progesterone, androgen, and prolactin receptors in neoplastic and normal mammary gland tissues and compare the expression of these receptors between groups. The second objective was to determine if the expression of these receptors in neoplastic mammary gland tissue correlates with overall survival and occurrence of an additional mass after initial mammary mass excision. The third objective was to determine if the expression of oestrogen, progesterone, androgen and prolactin receptors was associated with mammary tumor clinical parameters or with the age of the animals. Thirty‐two benign mammary tumours were collected from companion rats and submitted for immunohistochemistry staining of prolactin receptor, oestrogen receptor alpha (ERa), progesterone and androgen receptors (AR). Allred score were obtained for mammary tumours (n = 32) and surrounding normal mammary tissue (n = 20) when present. Prolactin receptor expression increased significantly with mammary gland tumorigenesis (P < .0001), while AR expression decreased with tumorigenesis (P < .0001). Lower expression of ERa in tumor stroma was associated with shorter survival (P = .02). Hormonal receptor expression was not significantly associated with age, mass diameter, location nor likelihood of additional mass development. Further studies should investigate the effects of prolactin antagonists in a prospective study involving companion rats with benign mammary tumours.
Outcomes of corneal neurotisation using processed nerve allografts: a multicentre case series
Authors: Sweeney Adam R , Wang Margaret , Weller Christopher L , Burkat Cat , Kossler Andrea L. , Lee Bradford W , Yen Michael T 
Published: November 2020

BackgroundCorneal neurotisation is a rapidly evolving procedure treating neurotrophic keratopathy. The variety of surgical techniques used and corresponding outcomes after corneal neurotisation are not well understood. This study describes the techniques and outcomes in the largest case series of corneal neurotisation using processed nerve allografts to date.MethodsThis is a retrospective case series of patients who underwent corneal neurotisation with human cadaveric processed nerve allografts. All patients had preoperative and postoperative description of best corrected visual acuity and measurement of corneal sensation. Comparative studies after stratification of techniques were performed.ResultsA total of 17 patients were identified. The cause of corneal anaesthesia was prior infection in eight cases, trigeminal nerve palsy in eight cases and ocular trauma in one case. There were no intraoperative or postoperative complications. Following neurotisation surgery, the time to first gain of corneal sensation and maximal gain of sensation occurred at a mean of 3.7 months (range 1–8 months) and 6.6 months (range 3–15 months), respectively. The mean preoperative and postoperative corneal sensation as measured by Cochet-Bonnet aesthesiometry was 0.36 cm (range 0–3.2 cm) and 4.42 cm (range 0–6 cm), respectively (p<0.01). Visual acuity was unchanged after neurotisation. There were no statistical differences in outcomes based on end-to-end versus end-to-side coaptations, donor nerve selection or laterality of donor nerve.ConclusionCorneal neurotisation with processed nerve allografts is a safe and effective procedure. This study provides further evidence for the use of processed nerve allografts for corneal neurotisation.
Prevalence and frequency of menstrual cycle symptoms are associated with availability to train and compete: a study of 6812 exercising women recruited using the Strava exercise app
Authors: Bruinvels Georgie , Goldsmith Esther , Blagrove Richard , Simpkin Andrew , Lewis Nathan , Morton Katie , Suppiah Ara , Rogers John P , Ackerman Kathryn E , Newell John , Pedlar Charles 
Published: November 2020

ObjectivesThe menstrual cycle can affect sports participation and exercise performance. There are very few data on specific menstrual cycle symptoms (symptoms during various phases of the cycle, not only during menstruation) experienced by exercising women. We aimed to characterise the most common symptoms, as well as the number and frequency of symptoms, and evaluate whether menstrual cycle symptoms are associated with sporting outcomes.Methods6812 adult women of reproductive age (mean age: 38.3 (8.7) years) who were not using combined hormonal contraception were recruited via the Strava exercise app user database and completed a 39-part survey. Respondents were from seven geographical areas, and the questions were translated and localised to each region (Brazil, n=892; France, n=1355; Germany, n=839; Spain, n=834; UK and Ireland, n=1350; and USA, n=1542). The survey captured exercise behaviours, current menstrual status, presence and frequency of menstrual cycle symptoms, medication use for symptoms, perceived effects of the menstrual cycle on exercise and work behaviours, and history of hormonal contraception use. We propose a novel Menstrual Symptom index (MSi) based on the presence and frequency of 18 commonly reported symptoms (range 0–54, where 54 would correspond to all 18 symptoms each occurring very frequently).ResultsThe most prevalent menstrual cycle symptoms were mood changes/anxiety (90.6%), tiredness/fatigue (86.2%), stomach cramps (84.2%) and breast pain/tenderness (83.1%). After controlling for body mass index, training volume and age, the MSi was associated with a greater likelihood of missing or changing training (OR=1.09 (CI 1.08 to 1.10); p≤0.05), missing a sporting event/competition (OR=1.07 (CI 1.06 to 1.08); p≤0.05), absenteeism from work/academia (OR=1.08 (CI 1.07 to 1.09); p≤0.05) and use of pain medication (OR=1.09 (CI 1.08 to 1.09); p≤0.05).ConclusionMenstrual cycle symptoms are very common in exercising women, and women report that these symptoms compromise their exercise participation and work capacity. The MSi needs to be formally validated (psychometrics); at present, it provides an easy way to quantify the frequency of menstrual cycle symptoms.