bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weekly Sequential Antibioprophylaxis for Recurrent Urinary Tract Infections Among Patients With Neurogenic Bladder: A Randomized Controlled Trial
Authors: Dinh Aurélien , Hallouin-Bernard Marie-Charlotte , Davido Benjamin , Lemaignen Adrien , Bouchand Frédérique , Duran Clara , Even Alexia , Denys Pierre , Perrouin-Verbe Brigitte , Sotto Albert , Lavigne Jean-Philippe , Bruyère Franck , Grall Nathalie , Tavernier Elsa , Bernard Louis 
Published: December 2019

Abstract

Background
Recurrent urinary tract infections (R-UTIs) are the main cause of morbidity and hospitalizations in subjects with neurogenic bladder (NB) due to spinal cord injury (SCI). We evaluated the efficacy of weekly oral cyclic antibiotic (WOCA) prophylaxis (ie, the alternate weekly administration of 2 antibiotics) in preventing R-UTIs.

Methods
Randomized (1:1), open-label, superiority-controlled trial compared WOCA prophylaxis to no prophylaxis (control) for 6 months in patients with NB due to SCI, using clean intermittent self-catheterization, and suffering from R-UTIs. Primary outcome was incidence of symptomatic antibiotic-treated UTIs. Secondary outcomes were number of febrile UTIs, number of hospitalizations, WOCA tolerance, antibiotic consumption, number of negative urine cultures, and emergence of bacterial resistance in urinary, intestinal, and nasal microbiota.

Results
Forty-five patients were either allocated to the WOCA group (n = 23) or the control group (n = 22). Median (IQR) incidence of symptomatic antibiotic-treated UTIs was 1.0 (0.5–2.5) in the WOCA group versus 2.5 (1.2–4.0) (P = .0241) in the control group. No febrile UTIs were recorded in the WOCA group versus 9 (45.0%) (P &lt; .001) in the control group. The median number of additional antibiotic treatment was 0.0 (IQR, 0.0–2.0) versus 3.0 (2.0–5.0) (P = .004) in the WOCA and control groups, respectively. Only few adverse events were reported. No impact on emergence of bacterial resistance was observed.

Conclusions
WOCA is efficient and well tolerated in preventing R-UTIs in SCI patients. In our study, we did not observe any emergence of antibiotic resistance in digestive and nasal microbiological cultures.

Clinical Trials Registration
NCT01388413.
Are machines stealing our jobs?
Authors: Gentili Andrea , Compagnucci Fabiano , Gallegati Mauro , Valentini Enzo 
Published: December 2019

AbstractThis study aims to contribute empirical evidence to the debate about the future of work in an increasingly robotised world. We implement a data-driven approach to study the technological transition in six leading Organisation for Economic Co-operation and Development (OECD) countries. First, we perform a cross-country and cross-sector cluster analysis based on the OECD-STAN database. Second, using the International Federation of Robotics database, we bridge these results with those regarding the sectoral density of robots. We show that the process of robotisation is industry- and country-sensitive. In the future, participants in the political and academic debate may be split into optimists and pessimists regarding the future of human labour; however, the two stances may not be contradictory.
Routinely measuring symptom burden and health-related quality of life in dialysis patients: first results from the Dutch registry of patient-reported outcome measures
Authors: van der Willik Esmee M , Hemmelder Marc H , Bart Hans A J , van Ittersum Frans J , Hoogendijk-van den Akker Judith M , Bos Willem Jan W , Dekker Friedo W , Meuleman Yvette 
Published: December 2019

AbstractBackgroundThe use of patient-reported outcome measures (PROMs) is becoming increasingly important in healthcare. However, incorporation of PROMs into routine nephrological care is challenging. This study describes the first experience with PROMs in Dutch routine dialysis care.MethodsA pilot study was conducted in dialysis patients in 16 centres. Patients were invited to complete PROMs at baseline and 3 and 6 months. PROMs consisted of the 12-item short-form and Dialysis Symptom Index to assess health-related quality of life (HRQoL) and symptom burden. Response rates, HRQoL and symptom burden scores were analysed. Qualitative research methods were used to gain insight into patients’ views on using PROMs in clinical practice.ResultsIn total, 512 patients (36%) completed 908 PROMs (24%) across three time points. Response rates varied from 6 to 70% among centres. Mean scores for physical and mental HRQoL were 35.6 [standard deviation (SD) 10.2] and 47.7 (SD 10.6), respectively. Patients experienced on average 10.8 (SD 6.1) symptoms with a symptom burden score of 30.7 (SD 22.0). Only 1–3% of the variation in PROM scores can be explained by differences between centres. Patients perceived discussing their HRQoL and symptom scores as insightful and valuable. Individual feedback on results was considered crucial.ConclusionsThe first results show low average response rates with high variability among centres. Dialysis patients experienced a high symptom burden and poor HRQoL. Using PROMs at the individual patient level is suitable and may improve patient–professional communication and shared decision making. Further research is needed to investigate how the collection and the use of PROMs can be successfully integrated into routine care to improve healthcare quality and outcomes.
Screening strategies for pulmonary arterial hypertension
Authors: Kiely David G , Lawrie Allan , Humbert Marc 
Published: December 2019

Abstract
Pulmonary arterial hypertension (PAH) is rare and, if untreated, has a median survival of 2–3 years. Pulmonary arterial hypertension may be idiopathic (IPAH) but is frequently associated with other conditions. Despite increased awareness, therapeutic advances, and improved outcomes, the time from symptom onset to diagnosis remains unchanged. The commonest symptoms of PAH (breathlessness and fatigue) are non-specific and clinical signs are usually subtle, frequently preventing early diagnosis where therapies may be more effective. The failure to improve the time to diagnosis largely reflects an inability to identify patients at increased risk of PAH using current approaches. To date, strategies to improve the time to diagnosis have focused on screening patients with a high prevalence [systemic sclerosis (10%), patients with portal hypertension assessed for liver transplantation (2–6%), carriers of mutations of the gene encoding bone morphogenetic protein receptor type II, and first-degree relatives of patients with heritable PAH]. In systemic sclerosis, screening algorithms have demonstrated that patients can be identified earlier, however, current approaches are resource intensive. Until, recently, it has not been considered possible to screen populations for rare conditions such as IPAH (prevalence 5–15/million/year). However, there is interest in the use of artificial intelligence approaches in medicine and the application of diagnostic algorithms to large healthcare data sets, to identify patients at risk of rare conditions. In this article, we review current approaches and challenges in screening for PAH and explore novel population-based approaches to improve detection.
Towards Responsible Implementation of Monitoring Technologies in Institutional Care
Authors: Grigorovich Alisa , Kontos Pia 
Published: December 2019

AbstractIncreasing awareness of errors and harms in institutional care settings, combined with rapid advancements in artificial intelligence, have resulted in a widespread push for implementing monitoring technologies in institutional settings. There has been limited critical reflection in gerontology regarding the ethical, social, and policy implications of using these technologies. We critically review current scholarship regarding use of monitoring technology in institutional care, and identify key gaps in knowledge and important avenues for future research and development.
The Scientist Citizen and the Citizen Scientist: Blurring the Lines
Authors: Warmbrod Lane , Trotochaud Marc , Connell Nancy 
Published: December 2019

Abstract
The scientific enterprise satisfies the innate human urge to understand the world; these efforts have led to both improvements and dangers to society. The storied history of relationships between scientists and citizens suggests that the lines between these 2 sectors of society are often blurred. Here we discuss these relationships on the context of animal welfare. We briefly outline the history of animal welfare in research, and the entry of citizens into the discussion, leading to the Animal Welfare Act of 1966. The commitment of scientists to society, in this context, is the act of whistleblowing in research. As medical and life sciences technologies continue to expand at breathtaking rates, the landscape that both scientists and citizens must navigate increases in complexity. We discuss the responsibility of both the scientist and the citizen, as members of the voting public, in the face of the challenges of the future.
Neuropathology in Neonatal Mice After Experimental Coxsackievirus B2 Infection Using a Prototype Strain, Ohio-1
Authors: Ushioda Waka , Kotani Osamu , Kawachi Kengo , Iwata-Yoshikawa Naoko , Suzuki Tadaki , Hasegawa Hideki , Shimizu Hiroyuki , Takahashi Kimimasa , Nagata Noriyo 
Published: December 2019

Abstract
Coxsackievirus B (CVB) causes severe morbidity and mortality in neonates and is sometimes associated with severe brain damage resulting from acute severe viral encephalomyelitis. However, the neuropathology of CVB infection remains unclear. A prototype strain of coxsackievirus B2 (Ohio-1) induces brain lesions in neonatal mice, resulting in dome-shaped heads, ventriculomegaly, and loss of the cerebral cortex. Here, we characterized the glial pathology in this mouse model. Magnetic resonance imaging revealed an absence of the cerebral cortex within 2 weeks after inoculation. Histopathology showed that virus replication triggered activation of microglia and astrocytes, and induced apoptosis in the cortex, with severe necrosis and lateral ventricular dilation. In contrast, the brainstem and cerebellum remained morphologically intact. Immunohistochemistry revealed high expression of the coxsackievirus and adenovirus receptor (a primary receptor for CVB) in mature neurons of the cortex, hippocampus, thalamus, and midbrain, demonstrating CVB2 infection of mature neurons in these areas. However, apoptosis and neuroinflammation from activated microglia and astrocytes differed in thalamic and cortical areas. Viral antigens were retained in the brains of animals in the convalescence phase with seroconversion. This animal model will contribute to a better understanding of the neuropathology of CVB infection.
“As Old as War Itself”? Historicizing the Universal Mercenary
Authors: Riemann Malte 
Published: December 2019

AbstractIR scholarship has increasingly begun to scrutinize the ahistorical and ahistoricist assumptions pervading the discipline. Specifically, attention has been turned to those concepts, actors, and practices that appear to be without history and that therefore assumed the status of universals. This article contributes to this scholarship by critically investigating the seemingly transhistorical figure of the mercenary, whose history, it appears, is little less than the history of organized warfare itself. This article questions this assumption by investigating how the Renaissance Landsknechte, actors invoked to support the transhistorical mercenary claim, were problematized within their own historical specificity. Through this analysis, this article rejects the notion that the mercenary is a transhistorical phenomenon as the ideas and categories associated with this figure are tied to specific modern accounts of statist political community and individual identity, as well as a modern account of self-interest. It is argued that the mercenary is not a phenomenon that predates the emergence of the modern state and the system of states, but its own existence is grounded within them. This article, thus, reinstates the historicity of this figure and argues that the mercenary is not “as old as war itself” but a product of specific modern conditions.
DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends
Authors: Bonetti Diego , Rinaldi Carlo , Vertemara Jacopo , Notaro Marco , Pizzul Paolo , Tisi Renata , Zampella Giuseppe , Longhese Maria Pia 
Published: December 2019

AbstractThe cellular response to DNA double-strand breaks (DSBs) is initiated by the Mre11–Rad50–Xrs2 (MRX) complex that has structural and catalytic functions. MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that binds telomeric DNA through two tandem Myb-like domains. Whether and how Rap1 acts at DSBs is unknown. Here we show that Rif2 inhibits MRX association to DSBs in a manner dependent on Rap1, which binds to DSBs and promotes Rif2 association to them. Rap1 in turn can negatively regulate MRX function at DNA ends also independently of Rif2. In fact, a characterization of Rap1 mutant variants shows that Rap1 binding to DNA through both Myb-like domains results in formation of Rap1-DNA complexes that control MRX functions at both DSBs and telomeres primarily through Rif2. By contrast, Rap1 binding to DNA through a single Myb-like domain results in formation of high stoichiometry complexes that act at DNA ends mostly in a Rif2-independent manner. Altogether these findings indicate that the DNA binding modes of Rap1 influence its functional properties, thus highlighting the structural plasticity of this protein.
MetaOmGraph: a workbench for interactive exploratory data analysis of large expression datasets
Authors: Singh Urminder , Hur Manhoi , Dorman Karin , Wurtele Eve Syrkin 
Published: December 2019

AbstractThe diverse and growing omics data in public domains provide researchers with tremendous opportunity to extract hidden, yet undiscovered, knowledge. However, the vast majority of archived data remain unused. Here, we present MetaOmGraph (MOG), a free, open-source, standalone software for exploratory analysis of massive datasets. Researchers, without coding, can interactively visualize and evaluate data in the context of its metadata, honing-in on groups of samples or genes based on attributes such as expression values, statistical associations, metadata terms and ontology annotations. Interaction with data is easy via interactive visualizations such as line charts, box plots, scatter plots, histograms and volcano plots. Statistical analyses include co-expression analysis, differential expression analysis and differential correlation analysis, with significance tests. Researchers can send data subsets to R for additional analyses. Multithreading and indexing enable efficient big data analysis. A researcher can create new MOG projects from any numerical data; or explore an existing MOG project. MOG projects, with history of explorations, can be saved and shared. We illustrate MOG by case studies of large curated datasets from human cancer RNA-Seq, where we identify novel putative biomarker genes in different tumors, and microarray and metabolomics data from Arabidopsis thaliana. MOG executable and code: http://metnetweb.gdcb.iastate.edu/ and https://github.com/urmi-21/MetaOmGraph/.
The relative importance of various mating criteria in copepods
Authors: Powers Matthew J , Wilson Alan E , Heine Kyle B , Hill Geoffrey E 
Published: December 2019

AbstractTo produce viable offspring, organisms may assess mates via criteria that include traits, such as sex, species, age, reproductive status, population identity and individual quality. Copepods are small, ubiquitous crustaceans that live in freshwater and marine systems around the world whose patterns of mate choice have been long studied in numerous species. Herein, we synthesized decades of experiments describing sexual selection in copepods to assess the importance of mating criteria. We used formal, meta-analytical techniques and mixed modeling to quantify the likelihood of non-random mating associated with mating criteria. In our synthesis of the scientific literature, we found that copepods use several criteria when assessing mates and that these criteria are associated with different likelihood estimates. We report the strongest likelihood of non-random mating when copepods assess the reproductive status of females or when copepods select between conspecific vs. heterospecific mates. We found weak likelihood of non-random mating in studies that provide mates from different populations or that manipulate operational sex ratio. Studies that directly test assessment of individual quality are sparse in copepods when compared to equivalent studies in vertebrates, and we encourage future researchers to explore whether copepods use individual characteristics as key mating criteria.
The Moderating Effect of Professional Self-Care Training on Novice Practitioners’ Organizational Citizenship Behavior in China
Authors: Wang Yean , Zhang Huan , Yang Yaya 
Published: December 2019

AbstractDue to recent challenges and the great burdens faced by social workers to provide social services, self-care is becoming more and more important to research and practice. This study empirically tested the long-term impact of self-care training provided during MSW education. In line with previous research on self-care among other social services practitioners, the panel data of MSW graduates nationwide showed the longitudinal impact of the self-care training in MSW programs on their organizational citizenship behaviors (OCBs) as novice practitioners. Specifically, authors identify self-care as a critical work contextual moderator of the effects of supervisor behavior, workplace social capital, and burnout on OCB. The study offers implications for education, practice, research, and the culture of the profession in China, and explicates the utility of the findings of self-care training’s impact for practitioners, students, educators, social service agency supervisors, and organizational and professional leaders. It is crucial to create a “culture of self-care” by integrating self-care in education and building a healthy workplace culture, which may shed light on how to sustain the social work profession in China and globally.
Drought tolerance of wild versus cultivated tree species of almond and plum in the field
Authors: Paudel Indira , Gerbi Hadas , Wagner Yael , Zisovich Annat , Sapir Gal , Brumfeld Vlad , Klein Tamir 
Published: December 2019

AbstractTrees of the genus Prunus produce some of the most widely consumed fruits globally. The combination of climate change-related warming and increased drought stress, scarcity of freshwater resources for irrigation, and increasing demands due to population growth creates a need for increased drought tolerance in these tree species. Recently, we have shown in the field that a native wild pear species performs better under drought than two cultivated pear species. Here, a comparative field study was conducted in Israel to investigate traits associated with drought tolerance in almond (cultivated Prunus dulcis (Mill.) D. A. Webb vs wild Prunus ramonensis Danin) and plum (cultivated Prunus domestica L. vs wild Prunus ursina Kotschy). Measurements of xylem embolism and shoot and root carbon reserves were done along a year, including seasonal drought in the wild and a 35-day drought experiment in the orchards. Synchronous measurements of native xylem embolism and shoot water potential showed that cultivated and wild almond trees lost ~50% of hydraulic conductivity at −2.3 and −3.2 MPa, respectively. Micro-CT images confirmed the higher embolism ratio in cultivated versus wild almond, whereas the two plum species were similar. Dynamics of tissue concentrations of nonstructural carbohydrates were mostly similar across species, with higher levels in cultivated versus wild plum. Our results indicate an advantage for the wild almond over its cultivated relative in terms of xylem resistance to embolism, a major risk factor for trees under drought stress. This result is in line with our previous experiment on pear species. However, the opposite trends observed among the studied plum species mean that these trends cannot be generalized. It is possible that the potential for superior drought tolerance in wild tree species, relative to their cultivated relatives, is limited to wild species from dry and hot habitats.
Innovative Classroom Upgrade: Simulating an Intensive Care Unit Environment in an Undergraduate Academic Classroom
Authors: Bautista Cynthia , Bartos Susan 
Published: December 2019

Abstract
There are limited opportunities for undergraduate nursing students to take part in hands-on critical care. A course was developed to expose students to the critically ill patient in the intensive care unit environment and introduce skills that students may not have the opportunity to engage in during their clinical hours. Led by two faculty currently practicing in critical care, this course used multiple learning modalities, including high-fidelity simulation; didactic teaching; online discussion; and narrative, reflective writing, to teach critical care concepts and entry-level skills.
Current state of occupational latex allergy
Authors: Raulf Monika 
Published: December 2019

Purpose of review
During the 1980s, natural rubber latex (NRL) emerged as a major cause of occupational allergy and asthma, especially in healthcare workers using powdered NRL gloves. Increased recognition of NRL allergies and transfer of research findings into prevention strategies resulted into an almost elimination of this health problem. Here, the current knowledge on allergens, their use in diagnostics, prevalence data of occupational NRL allergy and the status of prevention strategy are summarized.

Recent findings
While the current studies conducted in high-income countries show that prevention measures have reduced NRL allergy, this does not yet apply worldwide. For latex allergy diagnosis, it is important that recombinant allergens as reliable tools are available, because in several European countries and the United States, NRL skin prick test extracts and powdered latex gloves for bronchial challenge test are no longer commercially available, leading to a deficit in diagnostic tools. Due to the fact that latex is suitable with good properties as a raw material for gloves, alternatives with significantly lower protein content and without cross-reactive structures to latex proteins are sought.

Summary
Awareness of the sensitization risk associated with the use of latex gloves should still be present in all occupational settings.
Fertility preserving treatment for gynecologic malignancies: a review of recent literature
Authors: Coakley Katherine , Wolford Juliet , Tewari Krishnansu S. 
Published: December 2019

Purpose of review
A significant number of women diagnosed with a gynecologic malignancy meet criteria for fertility-sparing treatment. Women are continuing to delay childbearing; the importance of fertility-sparing therapy is, therefore, increasing. It is imperative that physicians understand the options for, and limitations of, these treatments.

Recent findings
Recent research has demonstrated improved outcomes for endometrial cancer by adding targeted hysteroscopic resection to progestin therapy. Cervical cancer research has focused on oncologic and pregnancy outcomes following management with radical trachelectomy, confirming its safety. Given the high rates of preterm birth following trachelectomy, studies have evaluated the adequacy of fertility counseling prior to treatment, and have looked for predictive factors for preterm birth. Additionally, research has shown a rise in the percentage of women receiving conservative treatment for both endometrial and cervical cancer.

Summary
With an increasing number of women seeking conservative treatment, physicians must understand the safety and implications of such therapy. Retrospective studies have demonstrated the safety of fertility-sparing treatment for both endometrial and cervical cancer; prospective research is currently underway to provide better guidance for future directions of fertility-sparing treatment for gynecologic malignancies.