bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration
Authors: Olney Nicholas T. , Ong Elise , Goh Sheng‐Yang M. , Bajorek Lynn , Dever Reilly , Staffaroni Adam M. , Cobigo Yann , Bock Meredith , Chiang Kevin , Ljubenkov Peter , Kornak John , Heuer Hilary W. , Wang Ping , Rascovsky Katya , Wolf Amelia , Appleby Brian , Bove Jessica , Bordelon Yvette , Brannelly Patrick , Brushaber Danielle , Caso Christine , Coppola Giovanni , Dickerson Bradford C. , Dickinson Susan , Domoto‐Reilly Kimiko , Faber Kelly , Ferrall Jessica , Fields Julie , Fishman Ann , Fong Jamie , Foroud Tatiana , Forsberg Leah K. , Gearhart Debra J. , Ghazanfari Behnaz , Ghoshal Nupur , Goldman Jill , Graff‐Radford Jonathan , Graff‐Radford Neill R. , Grant Ian , Grossman Murray , Haley Dana , Hsiung Gingyuek , Huey Edward D. , Irwin David J. , Jones David T. , Kantarci Kejal , Karydas Anna M. , Kaufer Daniel , Kerwin Diana , Knopman David S. , Kramer Joel H. , Kraft Ruth , Kremers Walter , Kukull Walter , Lapid Maria I. , Litvan Irene , Mackenzie Ian R. , Maldonado Miranda , Manoochehri Masood , McGinnis Scott M. , McKinley Emily C. , Mendez Mario F. , Miller Bruce L. , Onyike Chiadi , Pantelyat Alex , Pearlman Rodney , Petrucelli Len , Potter Madeleine , Rademakers Rosa , Ramos Eliana M. , Rankin Katherine P. , Roberson Erik D. , Rogalski Emily , Sengdy Pheth , Shaw Leslie M. , Syrjanen Jeremy , Tartaglia M. Carmela , Tatton Nadine , Taylor Joanne , Toga Arthur , Trojanowski John Q. , Weintraub Sandra , Wong Bonnie , Wszolek Zbigniew , Boxer Adam L. , Boeve Brad F. , Rosen Howard J. ,   on behalf of the ARTFL and LEFFTDS consortia
Published: November 2019

AbstractIntroductionThe Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects longitudinal studies were designed to describe the natural history of familial‐frontotemporal lobar degeneration due to autosomal dominant mutations.MethodsWe examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 MAPT, GRN, and C9orf72 family members, including 102 non–mutation carriers, 103 asymptomatic carriers, 43 mildly/questionably symptomatic carriers, and 72 carriers with dementia.ResultsAsymptomatic carriers showed similar scores on all clinical measures compared with noncarriers but reduced frontal and temporal volumes. Those with mild/questionable impairment showed decreased verbal recall, fluency, and Trail Making Test performance and impaired mood and self‐monitoring. Dementia was associated with impairment in all measures. All MAPT carriers with dementia showed temporal atrophy, but otherwise, there was no single cognitive test or brain region that was abnormal in all subjects.DiscussionImaging changes appear to precede clinical changes in familial‐frontotemporal lobar degeneration, but specific early clinical and imaging changes vary across individuals.
Tau‐positron emission tomography correlates with neuropathology findings
Authors: Lowe Val J. , Lundt Emily S. , Albertson Sabrina M. , Min Hoon‐Ki , Fang Ping , Przybelski Scott A. , Senjem Matthew L. , Schwarz Christopher G. , Kantarci Kejal , Boeve Bradley , Jones David T. , Reichard R. Ross , Tranovich Jessica F. , Hanna Al‐Shaikh Fadi S. , Knopman David S. , Jack Clifford R. , Dickson Dennis W. , Petersen Ronald C. , Murray Melissa E. 
Published: November 2019

AbstractIntroductionComparison of tau (flortaucipir) positron emission tomography (FTP‐PET) to autopsy is important to demonstrate the relationship of FTP‐PET to neuropathologic findings.MethodsAutopsies were performed on 26 participants who had antemortem FTP‐PET. FTP‐PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP‐PET signal.ResultsParticipants with Braak stages of IV or greater had elevated FTP‐PET signal. FTP‐PET was elevated in participants with Alzheimer's disease. An FTP‐PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP‐PET signal (rho's from 0.61 to 0.70, P ≤ .02).DiscussionElevated FTP‐PET reflects Braak IV or greater neuropathology. Participants with primary age‐related tauopathy and hippocampal sclerosis did not show elevated FTP‐PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP‐PET signal.
Neuropsychological Outcomes of Exposure to Hurricane Katrina and Relocation
Authors: Walling Erin , Tucker Phebe , Pfefferbaum Betty , Nguyen Christopher , Mistry Amit 
Published: November 2019

ABSTRACTObjective:Survivors of natural disasters are at risk for mental health sequela, including deficits in neurocognitive functioning. This study explores links between hurricane exposure and resulting psychiatric symptoms and deficits in cognitive processing, attention, learning, and memory.Methods:Relocated Katrina survivors and demographically matched controls completed neurocognitive tests assessing processing speed (Trail Making Test, Part A), mental flexibility (Trail Making Test, Part B), sustained attention (Conner’s Continuous Performance Test), and learning and memory (Rey Auditory-Verbal Learning Test). PTSD (Clinician-Administered PTSD Scale) and depressive symptoms (BDI- II) were also measured.Results:Survivors had more PTSD and depression symptoms and weaker performance in cognitive processing, mental flexibility, and sustained attention, but not memory and learning compared to controls. When controlling for depression and PTSD symptoms (analysis of covariances), only CPT-II response time remained significantly different for survivors, so that sustained attention deficits were independent of emotional symptoms.Conclusion:Survivors had more psychiatric symptoms and neurocognitive dysfunctions than controls in most assessed measures. Our study had mixed results in identifying cognitive deficits related to psychopathology. Results suggest that disaster survivors, even those without psychopathology, should be assessed for cognitive issues that may affect their ability to process post-disaster instructions and access assistance in recovery efforts.
The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease
Authors: Zhang Jennifer Q. J. , Saravanabavan Sayanthooran , Munt Alexandra , Wong Annette T. Y. , Harris David C. , Harris Peter C. , Wang Yiping , Rangan Gopala K. 
Published: November 2019

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease and is caused by heterozygous germ-line mutations in eitherPKD1(85%) orPKD2(15%). It is characterised by the formation of numerous fluid-filled renal cysts and leads to adult-onset kidney failure in ~50% of patients by 60 years. Kidney cysts in ADPKD are focal and sporadic, arising from the clonal proliferation of collecting-duct principal cells, but in only 1–2% of nephrons for reasons that are not clear. Previous studies have demonstrated that further postnatal reductions inPKD1(orPKD2) dose are required for kidney cyst formation, but the exact triggering factors are not clear. A growing body of evidence suggests that DNA damage, and activation of the DNA damage response pathway, are altered in ciliopathies. The aims of this review are to: (i) analyse the evidence linking DNA damage and renal cyst formation in ADPKD; (ii) evaluate the advantages and disadvantages of biomarkers to assess DNA damage in ADPKD and finally, (iii) evaluate the potential effects of current clinical treatments on modifying DNA damage in ADPKD. These studies will address the significance of DNA damage and may lead to a new therapeutic approach in ADPKD.
A nearshore Hirnantian brachiopod fauna from South China and its ecological significance
Authors: Huang Bing , Rong Jiayu , Harper David A.T. , Zhou Hanghang 
Published: November 2019

AbstractThe brachiopods collected from the Kuanyinchiao Beds (Hirnantian, uppermost Ordovician) in Meitan and Zunyi counties, northern Guizhou, include 13 species and one undetermined taxon, dominated by Hirnantia sagittifera (M'Coy, 1851) (which accounts for over one-third of the specimens), together with common Eostropheodonta hirnantensis (M'Coy, 1851). They are assigned to the Hirnantia–Eostropheodonta Community, which probably inhabited a shallow-water, nearshore Benthic Assemblage (BA) 2 to upper BA 3 environment. Population analysis shows that the community was well adapted to this environment after the first phase of the end-Ordovician mass extinction. Representative specimens of all the species are illustrated, and a new species, Minutomena missa, is described herein. The variation in Hirnantia sagittifera was noted in many of previous studies but was not statistically evidenced. Here we have measured representative specimens of that famous species from the major paleoplates and terranes in the world, along with other species assigned to the genus from South China. Having used principal component analysis (PCA), significant variations in the species are documented statistically and revised, and three nominal species, one subspecies, and two morphotypes are now reassigned to Hirnantia sagittifera sensu stricto.UUID: http://zoobank.org/references/3f83fb1e-a6dd-4585-9f9f-9586dad28244
Examining the link between religiousness and fitness in a behavioural ecological framework
Authors: Međedović Janko 
Published: November 2019

AbstractIn recent years there have been attempts to explain religiousness from an evolutionary viewpoint. However, empirical data on this topic are still lacking. In the present study, the behavioural ecological theoretical framework was used to explore the relations between religiousness, harsh environment, fitness (reproductive success and parental investment) and fitness-related outcomes (age at first birth, desired number of children and the romantic relationship duration). The data were collected from 461 individuals from a community sample who were near the end of their reproductive phase (54% females,Mage= 51.75; SD = 6.56). Positive links between religiousness, harsh environment, fitness and fitness-related outcomes were expected, with the exception of age at first birth, for which a negative association was hypothesized. Hence, the main assumption of the study was that religiousness has some attributes of fast life-history phenotypes – that it emerges from a harsh environment and enables earlier reproduction. The study findings partially confirmed these hypotheses. Religiousness was positively related to environmental harshness but only on a zero-order level. Religious individuals had higher reproductive success (this association was especially pronounced in males) but religiousness did not show associations with parental investment. Religiousness was positively associated with desired number of children and negatively associated with age at first birth, although the latter association was only marginally significant in the multivariate analyses. Finally, path analysis showed that desired number of children and age at first birth completely mediated the relation between religiousness and reproductive success. The data confirmed the biologically adaptive function of religiousness in contemporary populations and found the mediating processes that facilitate fitness in religious individuals. Furthermore, the findings initiate a more complex view of religiousness in a life-history context which could be fruitful for future research: a proposal labelled as ‘ontogeny-dependent life-history theory of religiousness’.
“Strict injunctions that the dogs should not be risked”: A revised hypothesis for this anecdote and others in narratives of Scott’s last expedition
Authors: May Karen , Lewis George 
Published: November 2019

AbstractThis article updates Karen May’s earlier 2012 hypothesis (Could Captain Scott have been saved? Revisiting Scott’s last expedition). In this revised hypothesis, Cecil Meares, not Surgeon E. L. Atkinson, originated the unsubstantiated statement that “Strict injunctions had been given by Scott that the dogs should not be risked in any way.” This hypothesis incorporates new information uncovered since 2012, specifically Meares’ misrepresentations during the Terra Nova expedition; Atkinson’s 1911 journal entries; Atkinson’s 1919 allegation that Meares had “disobeyed orders”; and Tryggve Gran’s “The Race for the South Pole between Scott and Amundsen”, a 1945/post-1945 document that appears to have been Roland Huntford’s source for anecdotes in Huntford’s 1979 Scott–Amundsen biography. The article gives a proposed chronology for how Meares’ early misrepresentations and Gran’s later misunderstandings influenced the decisions, and later presentations, of the Terra Nova expedition.
Characteristics and outcomes of children with congenital heart disease needing diaphragm plication
Authors: Foster Cortney B. , Cabrera Antonio G. , Bagdure Dayanand , Blackwelder William , Moffett Brady S , Holloway Adrian , Mishcherkin Vladimir , Bhutta Adnan 
Published: November 2019

AbstractBackground:Diaphragm dysfunction following surgery for congenital heart disease is a known complication leading to delays in recovery and increased post-operative morbidity and mortality. We aimed to determine the incidence of and risk factors associated with diaphragm plication in children undergoing cardiac surgery and evaluate timing to repair and effects on hospital cost and length of stay.Methods:We conducted a multi-institutional retrospective observational cohort study. Forty-three hospitals from the Pediatric Health Information System database were included, and a total of 112,110 patients admitted between January 2004 and December 2014 were analysed.Results:Patients less than 18 years of age who underwent cardiac surgery were included. Risk Adjustment for Congenital Heart Surgery was utilized to determine procedure complexity. The overall incidence of diaphragm dysfunction was 2.2% (n = 2513 out of 112,110). Of these, 24.0% (603 patients) underwent diaphragm plication. Higher complexity cardiac surgery (Risk Adjustment for Congenital Heart Surgery 5–6) and age less than 4 weeks were associated with a higher likelihood of diaphragm plication (p-value < 0.01). Diaphragmatic plication was associated with increased hospital length of stay (p-value < 0.01) and increased medical cost.Conclusions:Diaphragm plication after surgery for congenital heart disease is associated with longer hospital length of stay and increased cost. There is a strong correlation of prolonged time to plication with increased length of stay and medical cost. The likelihood of plication increases with younger age and higher procedure complexity. Methods to improve early recognition and treatment of diaphragm dysfunction should be developed.
Associations among eating behaviour traits, diet quality and food labelling: a mediation model
Authors: Jacob Raphaëlle , Drapeau Vicky , Lamarche Benoît , Doucet Éric , Pomerleau Sonia , Provencher Véronique 
Published: November 2019

AbstractObjective:To assess the associations among eating behaviour traits, food label use and diet quality and to evaluate if the association between eating behaviour traits and diet quality is mediated by food label use.Design:Eating behaviour traits were assessed using the Three-Factor Eating Questionnaire (TFEQ), the Restraint Scale and the Intuitive Eating Scale, whereas food label use was measured with the Label Reading Survey. Diet quality (Canadian Healthy Eating Index) was assessed with an FFQ.Setting:Cross-sectional study.Participants:Adults (n 385; mean (sd): BMI = 26·0 (4·9) kg/m2, age = 41·1 (15·0) years) involved in two previous experimental studies.Results:When controlling for potential covariates, general food label use (β = 1·18 (se 0·26), P < 0·0001) was the main determinant of diet quality, explaining 6·7 % of its variance. General food label use partly mediated the association between TFEQ-cognitive restraint and diet quality; the indirect effect (βindirect (se); 95 % CI) was stronger in men (0·32 (0·10); 0·15, 0·55) than women (0·16 (0·05); 0·08, 0·27). General food label use also partly mediated the negative association between unconditional permission to eat and diet quality; the indirect effect (βindirect (se); 95 % CI) was also stronger in men (−1·88 (0·55); −3·11, −0·96) than women (−1·03 (0·33); −1·81, −0·49).Conclusions:General food label use was the main determinant of diet quality and partly mediated the association between eating behaviour traits and diet quality. The stronger mediating effect observed in men suggests they rely more on food labelling when attempting to restrained themselves, which translates into better diet quality.
Compact bandpass filter with wide-stopband using substrate integrated waveguide cavities and short-circuited coplanar line
Authors: Azad Amit Ranjan , Mohan Akhilesh 
Published: November 2019

AbstractThis article presented a compact bandpass filter with wide-stopband performance. Two substrate integrated waveguide (SIW) cavities and a short-circuited coplanar line introduced between the two cavities are used to realize a compact third-order bandpass filter. The passband is generated by combining the resonant frequency of TE101 mode of the SIW cavities and the fundamental resonant frequency of the short-circuited coplanar line. The size of the proposed filter reduces significantly in comparison with conventional third-order SIW filters. Moreover, the center frequency (CF) and the bandwidth of the filter can be controlled by adjusting the structural parameters of the filter. In addition, the first higher-order mode TE102 of the SIW cavity is suppressed by minimizing the coupling of TE102 mode in order to obtain wide-stopband performance. The proposed filter is designed, fabricated, and measured, and the simulation and measurement results show a good agreement. The filter exhibits compact size, low loss, and a rejection higher than 20 dB up to 1.94f0.
Category Learning in Schoolchildren. Its Relation to Age, Academic Marks and Resolution Patterns
Authors: Casadevante Cristina , Romero Miriam , Fernández-Marcos Tatiana , Hernández José Manuel 
Published: November 2019

Abstract
The aim of this research was to study the learning process using an objective and computerized task. The performance of 466 schoolchildren aged between 6 and 11 in a category learning task, the Category Learning Test (CLT), was examined. The results showed evidence of category learning throughout the trials for the whole sample, F(7, 469) = 29.979, p <.001. In addition, categorization performance improved with age, H(2) = 48.475, p <.001. However, there were old children that struggled with the task and young children that performed very well. The ability to learn the categories was related to the children’s behavior when trying to solve the task: the response speed (r = –.217, p <.01) and the organization index (r = .247, p <.01). Nevertheless, performance in the task and academic marks were not related. We discuss the impact of these findings on the promotion and improvement of learning in schools: an intervention to promote slowness and organization might help some children to learn.
Intelligence and Personality
Authors: Bédard Marc-André , Le Corff Yann 
Published: November 2019

Abstract. This replication and extension of DeYoung, Quilty, Peterson, and Gray’s (2014) study aimed to assess the unique variance of each of the 10 aspects of the Big Five personality traits ( DeYoung, Quilty, & Peterson, 2007 ) associated with intelligence and its dimensions. Personality aspects and intelligence were assessed in a sample of French-Canadian adults from real-life assessment settings ( n = 213). Results showed that the Intellect aspect was independently associated with g, verbal, and nonverbal intelligence while its counterpart Openness was independently related to verbal intelligence only, thus replicating the results of the original study. Independent associations were also found between Withdrawal, Industriousness and Assertiveness aspects and verbal intelligence, as well as between Withdrawal and Politeness aspects and nonverbal intelligence. Possible explanations for these associations are discussed.
The Modifying Influence of Family Social Background on the Association Between IQ and Unsuccessful Educational and Occupational Achievement
Authors: Hegelund Emilie Rune , Flensborg-Madsen Trine , Dammeyer Jesper , Mortensen Erik Lykke 
Published: November 2019

Abstract. The present register-based study investigated whether family social background modified the association between intelligence and unsuccessful educational and occupational achievement among young men in Denmark. The study population comprised all men born during the period from 1981 to 1991 who had appeared before a draft board until 2015 ( N = 277,938). Family social background was measured by parental educational attainment at the birth of the study population. Intelligence was assessed by IQ scores on Børge Priens Prøve at age 18. Unsuccessful educational and occupational achievement were measured by no completed youth education at age 25, by no completed education leading to vocational qualifications at age 30, by not being in employment, education, or training (NEET) at age 30, and by gross income at age 30. Binary logistic regression and median regression were used to estimate the combined influence of family social background and IQ on unsuccessful educational and occupational achievement. The results showed that family social background modified the associations of IQ with risk of no youth education at age 25 and gross income at age 30, but the modifying influence seemed to depend on both the IQ level and the outcome indicator. Family social background was not found to modify the associations of IQ with risk of no vocational qualification at age 30 and risk of being NEET at age 30. In conclusion, the study findings suggest that several mechanisms might be at work in the complex and intertwined influences of family social background and intelligence on the risk of unsuccessful educational and occupational achievement.
Fractures and Subsidiary Faults Developed in the Active Strike‐Slip Nojima Fault Zone, Japan, and Tectonic Implications
Authors: Nishiwaki Takafumi , Lin Aiming 
Published: November 2019

AbstractThe Nojima Fault Zone, on which the 1995 Mw 6.9 Kobe (Japan) earthquake occurred, is characterized by pulverized cataclastic rocks with numerous fractures and subsidiary faults. The fractures and subsidiary faults were observed in trench walls and using borehole televiewer (BHTV) images from boreholes NFD‐1 (~1,000‐m depth) and AFD‐1 (~700‐m depth), which were drilled through the Nojima Fault and its branch, the Asano Fault, respectively. Measurements show that the orientations of fractures and subsidiary faults in the two boreholes are concentrated at N10–70°E, averaging N40°E. In contrast, the orientations of fractures and subsidiary faults in the walls of a trench across the main surface trace of the Asano Fault are constrained to N0–40°E, averaging N20°E, parallel to the general trend of the Asano Fault but different with that observed in the deep holes at the Ogura site. Structural analysis shows that the fractures and subsidiary faults are mainly concentrated in Riedel Y and R shears of the right‐lateral strike‐slip Nojima Fault and its branch Asano Fault. Our findings demonstrate that the fractures and subsidiary faults within the Nojima Fault Zone were formed by dextral strike‐slip shearing under the current ENE‐WSW to E‐W compressive regional tectonic stress field, related to ongoing subduction of the Pacific and Philippine Sea plates beneath the Japanese Islands.