bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction in Short-term Outpatient Consultations After a Campaign With Measles Vaccine in Children Aged 9–59 Months: Substudy Within a Cluster-Randomized Trial
Authors: Varma Anshu , Aaby Peter , Thysen Sanne Marie , Jensen Aksel Karl Georg , Fisker Ane Bærent 
Published: July 2020

Abstract

Background
We assessed a measles vaccination campaign’s potential short-term adverse events.

Methods
In a cluster-randomized trial assessing a measles vaccination campaign’s effect on all-cause mortality and hospital admission among children aged 9–59 months in Guinea-Bissau, children received a measles vaccination (intervention) or a health check-up (control). One month to 2 months later, we visited a subgroup of children to ask mothers/guardians about outpatient consultations since enrollment. In log-binomial models, we estimated the relative risk (RR) of nonaccidental outpatient consultations.

Results
Among 8319 children (4437 intervention/3882 control), 652 nonaccidental outpatient consultations occurred (322 intervention/330 control). The measles vaccination campaign tended to reduce nonaccidental outpatient consultations by 16% (RR, 0.84 [95% confidence interval {CI}, .65–1.11]), especially if caused by respiratory symptoms (RR, 0.68 [95% CI, .42–1.11]). The reduction tended to be larger in children who prior to trial enrollment had a pentavalent vaccination (diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b) as the most recent vaccination (RR, 0.61 [95% CI, .42–.89]) than in children who prior to trial enrollment had a routine measles vaccination as the most recent vaccination (RR, 0.93 [95% CI, .68–1.26]) (P = .04 for interaction).

Conclusions
In the short term, a measles vaccination campaign seems not to increase nonaccidental outpatient consultations but may reduce them.

Clinical Trials Registration
NCT03460002.
Exploring the origin of ultra-diffuse galaxies in clusters from their primordial alignment
Authors: Rong Yu , Mancera Piña Pavel E , Tempel Elmo , Puzia Thomas H , De Rijcke Sven 
Published: July 2020

ABSTRACT
We find that the minor axes of the ultra-diffuse galaxies (UDGs) in Abell 2634 tend to be aligned with the major axis of the central dominant galaxy, at a $\gtrsim 95{{\ \rm per\ cent}}$ confidence level. This alignment is produced by the bright UDGs with the absolute magnitudes Mr &lt; −15.3 mag, and outer-region UDGs with R &gt; 0.5R200. The alignment signal implies that these bright, outer-region UDGs are very likely to acquire their angular momenta from the vortices around the large-scale filament before they were accreted into A2634, and form their extended stellar bodies outside of the cluster; in this scenario, the orientations of their primordial angular momenta, which are roughly shown by their minor axes on the images, should tend to be parallel to the elongation of the large-scale filament. When these UDGs fell into the unrelaxed cluster A2634 along the filament, they could still preserve their primordial alignment signal before violent relaxation and encounters. These bright, outer-region UDGs in A2634 are very unlikely to be the descendants of the high-surface-brightness dwarf progenitors under tidal interactions with the central dominant galaxy in the cluster environment. Our results indicate that the primordial alignment could be a useful probe of the origin of UDGs in large-scale structures.
Evolutionary Genomics of Structural Variation in Asian Rice (Oryza sativa) Domestication
Authors: Kou Yixuan , Liao Yi , Toivainen Tuomas , Lv Yuanda , Tian Xinmin , Emerson J J , Gaut Brandon S , Zhou Yongfeng 
Published: July 2020

AbstractStructural variants (SVs) are a largely unstudied feature of plant genome evolution, despite the fact that SVs contribute substantially to phenotypes. In this study, we discovered SVs across a population sample of 347 high-coverage, resequenced genomes of Asian rice (Oryza sativa) and its wild ancestor (O. rufipogon). In addition to this short-read data set, we also inferred SVs from whole-genome assemblies and long-read data. Comparisons among data sets revealed different features of genome variability. For example, genome alignment identified a large (∼4.3 Mb) inversion in indica rice varieties relative to japonica varieties, and long-read analyses suggest that ∼9% of genes from the outgroup (O. longistaminata) are hemizygous. We focused, however, on the resequencing sample to investigate the population genomics of SVs. Clustering analyses with SVs recapitulated the rice cultivar groups that were also inferred from SNPs. However, the site-frequency spectrum of each SV type—which included inversions, duplications, deletions, translocations, and mobile element insertions—was skewed toward lower frequency variants than synonymous SNPs, suggesting that SVs may be predominantly deleterious. Among transposable elements, SINE and mariner insertions were found at especially low frequency. We also used SVs to study domestication by contrasting between rice and O. rufipogon. Cultivated genomes contained ∼25% more derived SVs and mobile element insertions than O. rufipogon, indicating that SVs contribute to the cost of domestication in rice. Peaks of SV divergence were enriched for known domestication genes, but we also detected hundreds of genes gained and lost during domestication, some of which were enriched for traits of agronomic interest.
Kidney allograft recipients, immunosuppression, and coronavirus disease-2019: a report of consecutive cases from a New York City transplant center
Authors: Lubetzky Michelle , Aull Meredith J , Craig-Schapiro Rebecca , Lee John R , Marku-Podvorica Jehona , Salinas Thalia , Gingras Laura , Lee Jun B , Sultan Samuel , Kodiyanplakkal Rosy Priya , Hartono Choli , Saal Stuart , Muthukumar Thangamani , Kapur Sandip , Suthanthiran Manikkam , Dadhania Darshana M 
Published: July 2020

Abstract

Background
Kidney graft recipients receiving immunosuppressive therapy may be at heightened risk for coronavirus disease 2019 (Covid-19) and adverse outcomes. It is therefore important to characterize the clinical course and outcome of Covid-19 in this population and identify safe therapeutic strategies.

Methods
We performed a retrospective chart review of 73 adult kidney graft recipients evaluated for Covid-19 from 13 March to 20 April 2020. Primary outcomes included recovery from symptoms, acute kidney injury, graft failure and case fatality rate.

Results
Of the 73 patients screened, 54 tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—39 with moderate to severe symptoms requiring hospital admission and 15 with mild symptoms managed in the ambulatory setting. Hospitalized patients were more likely to be male, of Hispanic ethnicity and to have cardiovascular disease. In the hospitalized group, tacrolimus dosage was reduced in 46% of patients and mycophenolate mofetil (MMF) therapy was stopped in 61% of patients. None of the ambulatory patients had tacrolimus reduction or discontinuation of MMF. Azithromycin or doxycycline was prescribed at a similar rate among hospitalized and ambulatory patients (38% versus 40%). Hydroxychloroquine was prescribed in 79% of hospitalized patients. Graft failure requiring hemodialysis occurred in 3 of 39 hospitalized patients (8%) and 7 patients died, resulting in a case fatality rate of 13% among Covid-19-positive patients and 18% among hospitalized Covid-19-positive patients.

Conclusions
Data from our study suggest that a strategy of systematic triage to outpatient or inpatient care, early management of concurrent bacterial infections and judicious adjustment of immunosuppressive drugs rather than cessation is feasible in kidney transplant recipients with Covid-19.
The use of future scenario thinking for child public health in a local authority
Authors: Mohiddin Abdu , Duggan Maria , Marsh Sheila , Dodhia Hiten , Oki Bimpe , Corlett Sarah 
Published: July 2020

Abstract

Background
Socioeconomic, cultural, technological, environment and ecological changes are rapidly transforming how children and young people (CYP) grow up, yet their impacts on CYP are difficult to predict. The traditional ways that Public Health practitioners work may not capture such complex and dynamic change. To address this, Lambeth Council used future scenario thinking.

Methods
A literature review looked at political, socioeconomic and other ‘transitions’ in the borough. Interviews, focus groups and workshops were held with CYP, parents, carers, local statutory and non-statutory stakeholders about the future for Lambeth CYP in the decade ahead. Themes were analysed to identify which had the potential for the biggest impact or the most uncertainty.

Results
The main transitions were described, 100 stakeholders interviewed, and five ‘drivers’ of the future were identified: protracted austerity, technological explosion, demographic shift, ‘democratic shake-up‘ and planetary health. From all these data, four future scenarios were developed: ‘communities care for themselves’, ‘collaborating to care for all’, ‘nobody cares’ and ‘who cares?’

Conclusions
New insights were gained about promoting more responsibility for, and active participation of CYP. This led to Lambeth’s CYP Plan and the ‘Made in Lambeth’ campaign aiming to enlist the community and business in creating a child-friendly borough.
High-frequency follow-up studies in musculoskeletal disorders: a scoping review
Authors: Tung Hsiu Yen , Galloway James , Matcham Faith , Hotopf Matthew , Norton Sam 
Published: July 2020

Abstract

Objectives
This scoping review identifies research in musculoskeletal disorders that uses high frequency follow-up of symptoms. The aim was to investigate whether symptom variability is investigated as a predictor of disease outcome and how intensive follow-up methods are used in musculoskeletal research.

Methods
Embase, MEDLINE and PsycInfo were searched using OVID, and the Institute of Electrical and Electronic Engineers was also searched using the Institute of Electrical and Electronic Engineers Xplore search engine. Studies were systematically reviewed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses, but no meta-analysis was done because the priority in this study is to identify gaps in available literature.

Results
Twenty-one papers were included. There was a mean of 54 patients per study (s.d. of 27.7). Two-thirds of the papers looked at how a symptom influences another in the short-term (subsequent assessment in the same day or next day), but none looked at the long-term. Only one study considered symptom variability investigating how higher variability in pain (defined by the s.d.) is associated with higher average pain severity and lower average sleep quality.

Conclusion
The methodology of musculoskeletal disorder research has changed from completing paper booklets to using electronic data capture (smartphones). There has also been a trend of collecting more intensive longitudinal data, but very little research utilizes these data to look at how symptom variability affects symptom outcomes. This demonstrates a gap in research where furthering understanding of this will help clinicians decide on the most important symptom to address in future patients.
How Intimate Partner Violence and Intersectional Identities Converge to Influence Women’s Sexual Health across Environmental Contexts
Authors: Bagwell-Gray Meredith E , Jen Sarah , Schuetz Nikolaus 
Published: July 2020

Abstract
In this qualitative study, authors examine women’s sexual risk and protective factors based on their experiences of intimate partner violence (IPV) and positioning within society relative to power. This analysis examines sexual risk and protective factors across intersectional identities—including gender, race, socioeconomic conditions, and age—among women survivors of IPV. The sample (N = 28) included women of diverse ages (range = 22–60 years) and races (57 percent White, 14 percent African American, 11 percent Hispanic, 7 percent Native American, 7 percent multiracial, and 4 percent South Asian). Findings demonstrated that IPV experiences differentially affect women’s sexual health according to intersectional identities and across various levels of environmental context by influencing the (in)stability of their lives and their experiences of (dis)empowerment. This analysis offers a nuanced understanding of how social workers can support women in planning for their own sexual health and safety and shows how an intersectional feminist framework enriches our understanding of the grand challenge to “build healthy relationships to end violence.”
The Role of Gender in Adolescent Dating Abuse: An Interpretive Meta-Synthesis of the Qualitative Literature
Authors: Storer Heather L , Schultz Katie , Hamby Sherry L 
Published: July 2020

Abstract
The role of gender has received considerable attention in the academic literature on intimate partner violence (IPV). The Grand Challenges for Social Work take a gender-neutral approach, without regard to the influence of gender on adolescent development and dating relationships. This positioning is inconsistent with gender mainstreaming approaches that have been integrated into international framings of IPV. The purpose of this article is to conduct a qualitative interpretive meta-synthesis to investigate how gender is represented in research on adolescent dating abuse across qualitative literature (N = 17 articles). Results underscore that gender influences the impact of abuse, with female adolescents more likely to be fearful in relationships, at higher risk for damage to their social standing, and more likely to be blamed for the abuse. Gender-specific attitudes affect perceptions of the seriousness of abuse, antecedents of abuse, and rationales for perpetrating violence. Findings across the studies indicate that adolescents have internalized gender scripts. Therefore, strategies to prevent dating abuse need to be cognizant of the socializing role of gender and the myriad ways it influences adolescents’ lived experiences. Therefore, the American Academy of Social Work and Social Welfare should consider revising the language of the existing challenges to mainstream gender.
Indigenous Women, Water Protectors, and Reciprocal Responsibilities
Authors: Dennis Mary Kate , Bell Finn McLafferty 
Published: July 2020

AbstractIndigenous women in North America have traditionally had reciprocal relationships with and responsibilities to the Earth. The process of colonization violently transformed both the treatment of the Earth and of Indigenous women. Current environmental crises highlight not only the vulnerability of Indigenous women, but also their long-standing leadership in resisting environmental injustices affecting their families, relationships, and nations. In this article, authors focus on the resistance of Dakota water protectors with the #NoDAPL movement in the United States and Anishinaabe water protectors in Mother Earth Water Walks in Canada. Recommendations for social workers in supporting Indigenous women in a thoughtful and effective way include incorporating a definition of a “social” response to more-than-human world relationships and responsibilities, supporting direct action as a necessary social response to environmental issues, and acting in solidarity with Indigenous women in these movements.
Collaborative Responses to Commercial Sexual Exploitation as a Model of Smart Decarceration
Authors: Abrams Laura S , Godoy Sarah M , Bath Eraka P , Barnert Elizabeth S 
Published: July 2020

Abstract
Historically, youths who are affected by commercial sexual exploitation (CSE) in the United States have been implicated as perpetrators of crime and overrepresented in the juvenile justice system. As an intriguing example of the “smart decarceration” social work grand challenge, policy and practice initiatives have converged to decriminalize cisgender girls and young women experiencing CSE by reframing them as victims of exploitation rather than as criminals. To date, these efforts have largely focused on gender-specific programming for cisgender girls and young women. In this article, the authors describe how federal, state, and local policy and practice innovations have supported reframing CSE as a form of child maltreatment and rerouted girls and young women from the juvenile justice system to specialized services. Using Los Angeles County as a case example, the authors detail how innovative prevention, intervention, and aftercare programs can serve as models of smart decarceration for CSE-affected cisgender girls and young women with the potential to address the needs of youths with diverse gender and sexual identities.
Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia
Authors: Rafael Lopez Jose , Kaura Vikas , Hopkins Phillip , Liu Xiaochen , Uryach Arkady , Adams Jose , Allen Paul D. 
Published: July 2020

Background
Until recently, the mechanism for the malignant hyperthermia crisis has been attributed solely to sustained massive Ca2+ release from the sarcoplasmic reticulum on exposure to triggering agents. This study tested the hypothesis that transient receptor potential cation (TRPC) channels are important contributors to the Ca2+ dyshomeostasis in a mouse model relevant to malignant hyperthermia.

Methods
This study examined the mechanisms responsible for Ca2+ dyshomeostasis in RYR1-p.G2435R mouse muscles and muscle cells using calcium and sodium ion selective microelectrodes, manganese quench of Fura2 fluorescence, and Western blots.

Results

RYR1-p.G2435R mouse muscle cells have chronically elevated intracellular resting calcium and sodium and rate of manganese quench (homozygous greater than heterozygous) compared with wild-type muscles. After exposure to 1-oleoyl-2-acetyl-sn-glycerol, a TRPC3/6 activator, increases in intracellular resting calcium/sodium were significantly greater in RYR1-p.G2435R muscles (from 153 ± 11 nM/10 ± 0.5 mM to 304 ± 45 nM/14.2 ± 0.7 mM in heterozygotes P < 0.001] and from 251 ± 25 nM/13.9 ± 0.5 mM to 534 ± 64 nM/20.9 ± 1.5 mM in homozygotes [P < 0.001] compared with 123 ± 3 nM/8 ± 0.1 mM to 196 ± 27 nM/9.4 ± 0.7 mM in wild type). These increases were inhibited both by simply removing extracellular Ca2+ and by exposure to either a nonspecific (gadolinium) or a newly available, more specific pharmacologic agent (SAR7334) to block TRPC6- and TRPC3-mediated cation influx into cells. Furthermore, local pretreatment with SAR7334 partially decreased the elevation of intracellular resting calcium that is seen in RYR1-p.G2435R muscles during exposure to halothane. Western blot analysis showed that expression of TRPC3 and TRPC6 were significantly increased in RYR1-p.G2435R muscles in a gene–dose–dependent manner, supporting their being a primary molecular basis for increased sarcolemmal cation influx.

Conclusions
Muscle cells in knock-in mice expressing the RYR1-p.G2435R mutation are hypersensitive to TRPC3/6 activators. This hypersensitivity can be negated with pharmacologic agents that block TRPC3/6 activity. This reinforces the working hypothesis that transient receptor potential cation channels play a critical role in causing intracellular calcium and sodium overload in malignant hyperthermia–susceptible muscle, both at rest and during the malignant hyperthermia crisis.

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Repeated administration of inorganic nitrate on blood pressure and arterial stiffness: a systematic review and meta-analysis of randomized controlled trials
Authors: Li Dandan , Nishi Stephanie K. , Jovanovski Elena , Zurbau Andreea , Komishon Allison , Mejia Sonia Blanco , Khan Tauseef A. , Sievenpiper John L. , Milicic Davor , Jenkins Alexandra , Vuksan Vladimir 
Published: July 2020

Objective:
We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures.

Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arterial stiffness in individuals with or without elevated cardiovascular disease risk. MEDLINE, EMBASE and the Cochrane Library were searched through 2 July 2019. Two independent reviewers extracted relevant study data. Data were pooled using the generic inverse variance method with random-effects model, and expressed as mean differences with 95% confidence intervals. Certainty in the evidence was assessed using GRADE.

Results:
Forty-seven trials were included (n = 1101). Administration of inorganic nitrate significantly lowered SBP [mean difference: −2.91 mmHg, 95% confidence interval (95% CI): −3.92 to −1.89, I
2 = 76%], DBP (mean difference: −1.45 mmHg, 95% CI: −2.22 to −0.68, I
2 = 78%], central SBP (mean difference: −1.56 mmHg, 95% CI: −2.62 to −0.50, I
2 = 30%) and central DBP (mean difference: −1.99 mmHg, 95% CI: −2.37 to −1.60, I
2 = 0%). There was no effect on 24-h blood pressure, augmentation index or pulse wave velocity. Certainty in the evidence was graded moderate for central blood pressure, pulse wave velocity and low for peripheral blood pressure, 24-h blood pressure and augmentation index.

Conclusion:
Repeated administration (≥3 days) of inorganic nitrate lower peripheral and central blood pressure. Results appear to be driven by beneficial effects in healthy and hypertensive individuals. More studies are required to increase certainty in the evidence.
A novel angiotensin II peptide vaccine without an adjuvant in mice
Authors: Nakamaru Ryo , Nakagami Hironori , Hayashi Hiroki , Sun Jiao , Tenma Akiko , Yamamoto Koichi , Shimamura Munehisa , Morishita Ryuichi , Rakugi Hiromi 
Published: July 2020

Objectives:
We recently developed a novel peptide, AJP001, that possesses both a mouse T-cell epitope and adjuvant action. Direct conjugation to the antigen is useful for peptide vaccines without the addition of adjuvants. In this study, the efficacy of an angiotensin (Ang) II and AJP001-conjugated peptide vaccine (AJ-Ang II) was evaluated in mice.

Methods:
The anti-Ang II antibody titer was measured in Balb/C mice following three injections of AJ-Ang II at 2-week intervals. SBP was measured during vaccination of Balb/C mice treated with Ang II infusion (1 μg/kg per min).

Results:
AJ-Ang II treatment resulted in an increase in the anti-Ang II antibody titer in a dose-dependent manner without the addition of adjuvants. In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. Importantly, cotreatment with purified antibodies attenuated Ang II-induced extracellular signal-regulated kinase phosphorylation and nuclear factor (NF)-κB activation in cultured vascular smooth muscle cells. The SBP in immunized mice was significantly lower than that in nonimmunized mice (135.9 ± 8.5 vs. 154.9 ± 16.8 mmHg, P = 0.02). Furthermore, Ang II-induced perivascular fibrosis in the heart was significantly attenuated in immunized mice, which also exhibited decreased mRNA expression of collagen I/III and transforming growth factor-β.

Conclusion:
AJ-Ang II may be a simple and useful therapeutic peptide vaccine without the addition of any adjuvants.