bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULATION AND OPTIMIZATION BY APPLYING 32 FULL FACTORIAL DESIGN OF MUCOADHESIVE MICROSPHERES OF NIFEDIPINE
Authors: CHIMAN LAL  , RAJEEV GARG  , GHANSHYAM DAS GUPTA  
Published: October 2019

Objective: The purpose of this research work is to formulate and optimize mucoadhesive microspheres of nifedipine using Carbopol 934P as mucoadhesive and ethyl cellulose as a carrier polymer for controlling the release of nifedipine.
Methods: The emulsion solvent evaporation technique was used for the preparation of microspheres and the 32 full factorial designs were employed for optimization of microspheres. The developed microspheres were characterized for percent yield, entrapment efficiency, particle size, in vitro release study, percent mucoadhesion, surface morphology, and stability study.
Results: Evaluating outcomes of preliminary batches indicated that 100 ml volume of processing medium, 5 h stirring time and 2% concentration of emulsifying agent were suitable for spherical, free-flowing microspheres and high percentage drug entrapment efficiency. The optimized batch exhibited 84.35% drug entrapment efficiency, 61.78% mucoadhesion and drug release were also sustained for more than 12 h. Scanning electron microscopy study revealed that produced microspheres were spherical in shape.
Conclusion: Experimental responses of the optimized batch have close proximity with the predicted value and stability study of the optimized formulation proved the formulation is stable for a long period of time; hence, it is an excellent alternative over the conventional delivery system.
A IMPACT OF A PHARMACIST-LED EDUCATIONAL INTERVENTION ON QUALITY OF LIFE AMONG PATIENTS WITH ASTHMA
Authors: QUYNH THI HUONG BUI  , KHOI XUAN PHAM  , TIEN HOANG TRAN  , LAN THI TUYET LE  , HO NHU NGUYEN  
Published: October 2019

Objectives: Asthma is a chronic disease resulting in reduced quality of life (QoL) of most affected individuals. Training in asthma-related knowledge, inhaler skills, medicine usage, and the prevention of adverse drug events is demonstrated to improve asthma patients’ QoL. Therefore, the research was conducted to evaluate the effectiveness of education intervention undertaken by pharmacists on QoL of patients with asthma.
Methods: We conducted a clinical randomized controlled trial among asthmatic outpatients aged 18 years or older in the Department of Screening Respiratory Function, University Medical Center, Ho Chi Minh City, Vietnam. Patients were randomized into an intervention group (IG) and a non-IG (NIG). The clinical pharmacists’ intervention program included training in asthma-related knowledge, inhaler technique, recognition, prevention of adverse drug events, and lifestyle adjustment. Participant screening was conducted using the telephone on a monthly basis. QoL was measured using the Vietnamese Version of the Mini Asthma QoL Questionnaire (MiniAQLQ). The main outcome was the difference in QoL scores between IG and NIG after 3 months follow-up.
Results: After 3 months, the number of patients with asthma in the IG and in the NIG was 173 and 96, respectively. QoL mean scores in the IG patients were significantly higher than those in their NIG counterparts (1.79±1.01 vs. 1.06±0.93, respectively, p<0.001). Pharmacist-based interventions overall QoL scores (multivariate-adjusted regression coefficient =0.362; p<0.001).
Conclusions: Clinical pharmacist-led counseling can improve asthmatic patients’ QoL.
FORMULATION AND EVALUATION OF METRONIDAZOLE TABLETS USING NATURAL GUM
Authors: SUDIPTA DAS  , SOUMITRA DAS  
Published: October 2019

Objectives: The objective of the present study was to formulate the metronidazole tablets using natural Aloe vera gum as binding agent.
Materials and Methods: To determine the binding properties of the extracted A. vera gum were used for the preparation of metronidazole tablets and compared with other binding agents such as acacia and sodium carboxymethyl cellulose (CMC). Physical properties such as hardness, friability, disintegration time, and in vitro dissolution rate are the important parameter which determines for each formulation. Three batches of metronidazole tablets are prepared using acacia (F1), sodium CMC (F2), and A. vera gum (F3) as binding agent.
Results: The granules were evaluated by determining the angle of repose (26.01 ± 0.110–27.18 ± 0.166°), bulk density, tapped density, Hausner ratio, and Carr’s index. It shows satisfactory results. At time 90 min, the percentage release of drug for F1, F2, and F3 was 44.947%, 31.467%, and 53.424%, respectively. The tablets prepared with A. vera gum showed faster release profile than other binders.
Conclusion: From the results, it was shown that tablets prepared with A. vera gum have good binding properties and also helped tablets for faster release.
OSTEOMETRIC ESTIMATION OF SEX FROM MASTOID TRIANGLE IN MALAYSIAN POPULATION
Authors: ABDELNASSER IBRAHIM  , ASPALILAH ALIAS  , MOHAMED SWARHIB SHAFIE  , SRIJIT DAS  , FARIDAH MOHD NOR  
Published: October 2019

Objective: Determination of sex is one of the most important parameters for conducting biological profile of unknown skeletal remains in anatomical anthropology and forensic medicine. Mastoid bone is useful for the identification of sex, as it is the most protected bone and is resistant to damage, due to its anatomical position at the base of the skull. The aim of this study was to develop new equation for the estimation of sex from mastoid triangle in the Malaysian population.
Methods: About 10 parameters were studied on 388 computed tomography scans of crania in 231 males and 157 females. The parameters comprised three sides of mastoid triangle, its perimeter and area on both sides. T-test was used to compare between the right and left sides and between males and females. Stepwise discriminant function was used to reveal the best discriminatory parameter and its classification accuracy.
Results: Comparison of means by T-test revealed no difference between the right and left sides in both sexes. T-test showed a significant difference between males and females for all parameters. Perimeter of mastoid triangle was found to be the best parameter by stepwise discriminant analysis. The equation based on perimeter of mastoid triangle was developed with 84.4% classification accuracy.
Conclusion: The developed equation could be used to assess sexual dimorphism of fragmented Malaysian crania with intact mastoid region. The achieved cross-validated classification was relatively high compared to that in other previous studies.
OSTEOMETRIC ANALYSIS OF SUPRAORBITAL FORAMEN AND NOTCH IN MALAYSIAN CRANIA
Authors: ABDELNASSER IBRAHIM  , SOHAYLA M ATTALLA  , ASPALILAH ALIAS  , MOHAMED SWARHIB  , SITI NOORAIN ABU BAKAR  , SRIJIT DAS  , FARIDAH MOHD NOR  
Published: October 2019

Objective: A clear knowledge of the location of supraorbital foramen (SOF) is vital for the surgeons, particularly in endoscopic surgery and regional block in crania. The aim of this study was to analyze SOF and notch in skulls of various ancestries.
Methods: The anatomical variations of SOF and notch were examined in 100 adults skulls (55 males and 45 females) of the Malay, Chinese, and Indian ancestries by traditional measurement made with the Osirix software. The parameters included distance between supraorbital structure and nasal midline, shape, and transverse diameter of the SOF.
Results: It was manifested that bilateral supraorbital notch (SON) was the most prevalent combination in both sexes and ancestries (61%), while combined SON and foramen (11%) were the least prevalent characteristic. The mean distances of supraorbital structure from nasal midline bilaterally in males were slightly greater than females. The horizontal diameter of SOF, notch and their distances from the nasal midline showed no difference between ancestries.
Conclusion: This study would serve as a guide for the surgeons when surgery is performed on the scalp. It can help in the precise determination of reference points for supraorbital nerve blockade for the Malaysians. In addition, the variations exhibited in supraorbital measurements inevitably revealed that sex and ancestry should be taken into consideration when choosing samples for anatomical classification of crania.
Imposition of Civilization by Depriving Livelihood and Vanishing Ethnicity of Tribal’s people
Authors: Padmanaban V. 
Published: October 2019

This research article exerts the origin, turmoil, anguish and lamentation of the Dakotas and Sioux nations and to retrieve their lands and to preserve their ethnicity and the demises of their predecessors at Wounded Knee massacre and superseded unwritten literature and history of Dakotas and massacre in at the start of fourteenth century and devastation of livelihood of the indigenous people and the cruelty of American Federal government still lingers in their mind. Treaty conserved indigenous people’s lands but Dakotas had been forced off their homelands due to the anti-Indian legislation, poverty and federal Indian – white American policy. The whites had no more regard for or perceiving the native peoples’ culture and political status as considered by Jefferson’s epoch. And this article exposes collecting bones and Indian words, delayed justices, inter- state issues and ignorance, racism and imperialism and the struggles of the Dakotas, whose future filled with uncertainty by reality and lose of land and cattle over the recent past centuries.
Stephen Gill Pens Poetry for Personal Therapy
Authors: Rao Dr. Aksa 
Published: October 2019

About 300 years before Christ, Aristotle describes catharsis in his Poetics to show the impact of true tragedy on the audience. In the nineteenth century, Josef Breuer, the companion of Sigmund Freud, was the first to use Aristotelian concept in the realm of psychology. One template of catharsis is the use of a musical instrument for a tired person to feel relaxed. In literature, one example is Oedipus Rex in which Oedipus unknowingly marries his biological mother. Another example is Shakespeare’s Romeo and Juliet. It is often said that reading any work about murder or to see it on the television can be a healing therapy.
Maslow’s Hierarchy of Needs in “Button Button” by Richard Matheson
Authors: Anwar Muhammad Javaid , Sattar Basri , Anwar Muhammad Naveed 
Published: October 2019

A short stories author and novelists named Richard Matheson was born on 1926 in US state New Jersey. Story writer Richard Matheson is best known for his science fiction’s works. His first story was “Born Man and Woman.” He also earned a good name for his popular fiction “I am Legend” as well as due to short story “Button Button” He passed away on June 23, 2013 (Editors, 2014). Alike various famous novelists and story writers Matheson also leave a deep impression of his readers. He also turned minor incidents and situations into extraordinary situations.
Improved method for separation of silver nanoparticles synthesized using the Nyctanthes arbor-tristis shrub
Authors: Gupta Aakash , Koirala Agni Raj , Gupta Bikash , Parajuli Niranjan 
Published: October 2019

Abstract
Plant-mediated synthesis of silver nanoparticles through green chemistry approach has evolved into a new era of research; however, the heterogeneous size and dispersity of silver nanoparticles have limited its applications, such as surface-enhanced Raman scattering, plasmon resonance, and more specifically in the medical field of target drug delivery and therapeutic activity. Here-we investigated the effect of purification and separation modes on the dispersity, size, and morphology of silver nanoparticles, synthesized by plant extract (Nyctanthes arbor-tristis). Transmission electron microscopy revealed silver nanoparticles with an average diameter of 13.0 nm when synthesized through ethanol precipitation, which is advantageously smaller. This result suggests that the silver nanoparticles size can be fine-tuned by changing the separation mode during purification from plant extract. Due to uniformity, our obtained nanoparticles can be expected to show higher catalytic activity towards photochemical reactions, drug delivery and antibacterial activity due to the absence of inactive coating layer (capping agent).
Growth of Potato Shoot Cultures on Media with Antibiotics for Elimination of Bacterial Contamination
Authors: Gubišová Marcela , Gubiš Jozef 
Published: October 2019

Abstract
The aim of our work was to evaluate the effect of selected antibiotics on the growth of potato shoot cultures in the Gene Bank of the Slovak Republic collection and to determine the type and dose that may be used to treat potato cultures endangered by endophytic bacteria. Antibiotics Chloramphenicol at doses 20, 50 and 100 mg/L, Gentamycin and Rifampicin in doses 20, 50, 100, 200 mg/L and the combination of Gentamycin and Rifampicin with 100 mg/L of each were used. Growth parameters – the shoot length and the number of nodal segments per shoot and rooting of ten cultivars of Solanum tuberosum L. of different origin were evaluated. Chloramphenicol already at the lowest dose had the strong inhibitory effect on regeneration, growth, and rooting of shoots. Gentamycin inhibited the growth of shoots gradually with increasing dose of it, rooting of shoots was negatively affected using the dose 50 mg/L or higher. Rifampicin up to 100 mg/L had the minimal effect on the shoots growth, rooting of shoots was not affected, but shoots were characterised by smaller or stunted leaves. Although the growth of shoots was affected, all ten genotypes used in the experiments were able to regenerate and grow at the highest dose of Rifampicin and Gentamycin. According to the results, it is highly probable that these antibiotics up to 100 mg/L or their combination would be suitable for culture preservation of the most genotypes in the gene-bank collection. On the other hand, Chloramphenicol cannot be recommended due to its strong detrimental effect on potato shoot cultures.
Effect of Planting Methods on the Quality of Three Egyptian Rice Varieties
Authors: Bassuony Nessreen N. , Zsembeli József 
Published: October 2019

Abstract
In Egypt, the traditional transplanting method of rice planting is substituted by broadcasting and dibbling recently. This paper studies the effects and the changes occur in different rice varieties due to different methods on grain quality and amino acids of rice. Three Egyptian rice cultivars belonging to japonica, japonica/indica and indica subspecies were investigated for grain quality, protein and amino acid composition under three planting methods, i.e., broadcasting, seedling transplanting and dibbling. A strip plot design with three replications was used; the investigated three rice cultivars occupied the horizontal main plot, while three planting methods were devoted to the vertical main plot. The method of planting did not affect significantly the grain dimension, but it affected significantly the milling characters and the 1,000-grain weight. The highest milling characters and 1,000-grain weight came from transplanting, while the lowest one from the dibbling method. There was no significant difference between transplanting and broadcasting in milling characters and 1,000-grain weight. The chemical and cooking characters of grains showed no significant differences in moisture content and gelatinization temperature characters, while the differences in protein content and elongation were significant among the varieties and planting methods. The interaction between the planting method and rice had significant effect on the protein content. The most important essential amino acids according to the FAO/WHO pattern were not affected significantly by the different methods of planting. This means that the biological value of rice grains is not affected by different methods of planting.
Assessment of the Contamination Level of a Podzolized Chernozem with Nuclides in a Long-term Land Use
Authors: Hospodarenko Hrygorii , Prokopchuk Ihor , Nikitina Olga , Liubych Vitalii 
Published: October 2019

Abstract
Prolonged systematic application of mineral fertilisers contributes to increasing the yielding capacity of agricultural crops. However, it can lead to significant changes in the composition, properties and formation of agricultural soil regimes. The findings of the research have shown that the application of mineral fertilisers leads to the change of radioactive nuclides content in the soil. The research was conducted under conditions of a long-term stationary field experiment (Uman, Ukraine), using different rates of mineral fertilisers N45P45K45, N90P90K90 and N135P135K135. Soil samples (podzolized chernozem) were selected from the depths of 0 – 20, 20 – 40 and 40 – 60 cm. Specific activity of radionuclides was determined by the spectrometric analysis. Using experimental results we have demonstrated that under a long-term application (50 years) different rates of mineral fertilisers effect the specific activity of radioactive isotopes in the soil (226Ra, 232Th, 40K, 137Cs, 90Sr). The specific activity of radionuclides in a podzolized chernozem and in winter wheat grain was established. Winter wheat plants accumulated 232Th at the highest levels, but the use of fertilisers reduced it in a larger mass of the crop. The absorption of radioactive nuclides by winter wheat grain grown after peas and silage corn depending on fertilisation changed similar to growing it after clover as a previous crop. According to the data of specific activity of radioactive nuclides in the soil and winter wheat grain, the coefficient of their biological absorption was calculated.
Characterization of Fabric-to-Fabric Friction: Application to Medical Compression Bandages
Authors: Chassagne Fanette , Benoist Emilie , Badel Pierre , Convert Reynald , Schacher Laurence , Molimard Jérôme 
Published: October 2019

AbstractFabric-to-fabric friction is involved in the action mechanism of medical compression devices such as compression bandages or lumbar belts. To better understand the action of such devices, it is essential to characterize, in their use conditions (mainly pressure and stretch), the frictional properties of the fabrics they are composed of. A characterization method of fabric-to-fabric friction was developed. This method was based on the customization of the fourth instrument of the Kawabata Evaluation System, initially designed for fabric roughness and friction characterization. A friction contactor was developed so that the stretch of the fabric and the applied load can vary to replicate the use conditions. This methodology was implemented to measure the friction coefficient of several medical compression bandages. In the ranges of pressure and bandage stretch investigated in the study, bandage-to-bandage friction coefficient showed very little variation. This simple and reliable method, which was tested for commercially available medical compression bandages, could be used for other medical compression fabrics.
Insights on the relationship between structure vs. toxicological activity of antibacterial rhodamine-labelled 3-hydroxy-4-pyridinone iron(III) chelators in HepG2 cells
Authors: Moniz Tânia , Dias da Silva Diana , Carmo Helena , de Castro Baltazar , de Lourdes Bastos Maria , Rangel Maria 
Published: October 2019

Abstract
In the present study we investigated the in vitro hepatotoxicity of a set of rhodamine-labelled 3-hydroxy-4-pyridinones (3,4-HPO) that had previously demonstrated significant inhibitory effect in the intramacrophagic growth of Mycobacterium avium. Our aim was to establish a correspondence between the molecular structure and the in vitro toxicological activity of these compounds.
The impact of a set of bidentate (MRB2, MRB7, MRB8, and MRB9) and hexadentate (MRH7, MRH8, and MRH10) chelators on cellular metabolic competence and membrane integrity was investigated in HepG2 cells.
Our findings indicate that: a) hexadentate chelators are more cytotoxic than parent bidentate ligands; b) disruption of cell membrane and metabolic competence only occurred after 5 days, at the highest concentrations tested; c) strict correlation between bacteriostatic activity and in vitro toxicity was observed, which seems to be directly dependent on the size of the molecule and on the hydrophilic/lipophilic balance; d) among the set of bidentate ligands, carboxyrhodamine derivatives (amide linker) presented lower detrimental effects, when compared with rhodamine B isothiocyanate chelators (thiourea linker); e) contrarily, for the hexadentate series, rhodamine B isothiocyanate derivatives are less cytotoxic to HepG2 cells than carboxyrhodamine molecules; and f) for all compounds tested, when the substituents of the nitrogen atom were switched from ethyl to methyl, an increment of toxicity was observed.
Overall, all chelators seem to display suitable in vitro toxicological potential to combat fast grow bacteria. According to their in vitro pharmacological: toxicological potential ratio, MRH7 and MRH8 may be considered as the most suitable compounds to undergo further pre-clinical development studies.
New biological findings of ethanol and chloroform extracts of fungi Suillellus rubrosanguineus and Tylopilus felleus
Authors: Šušaníková Ivana , Kvasnicová Adriána , Brzková Žofia , Ďuriška Ondrej , Mučaji Pavel 
Published: October 2019

Abstract
The aim of the research was to determine some basic biological activities of less biomedically studied but commonly known two fungi from the Boletaceae family Suillellus rubrosanguineus and Tylopilus felleus, which grow in the forests of Middle Europe. The cytotoxicity tests of the ethanol and chloroform extracts were carried out using NIH-3T3 and MCF-7 cell lines. The presence of alkaloids in the extracts was assessed by the reaction with Dragendorff reagent. In all of the extracts the positive reaction with the reagent was observed. In general, the extracts from Suillellus rubrosanguineus were more cytotoxic than the extracts from Tylopilus felleus and exhibited no selectivity of activities on healthy and cancer cell lines. However, the extracts from Tylopilus felleus proved to be selectively cytotoxic for cancer cell line. Tylopilus extracts or their isolated bioactive compounds could be considered for further study in pre-clinical experiments.
In vivo analysis of Bisphenol A induced dose-dependent adverse effects in cauda epididymis of mice
Authors: Samova Sanman , Doctor Hetal , Verma Ramtej 
Published: October 2019

Abstract
Bisphenol A is widely used as a material for the production of epoxy resins and polycarbonate plastics. It contaminates various food stuffs by getting leached out from their container lining. Limited information is available on its effects on the male reproductive system. The aim of the present study was to evaluate the extent to which bisphenol A can affect the reproductive system by measuring biochemical and histological changes in the epididymis. Inbred Swiss strain male albino mice were orally administered 80, 120 and 240 mg/kg body weight/day of BPA for 45 days. After completion of treatment, the animals were sacrificed; cauda epididymis was isolated, weighed, used for biochemical and histopathological studies. The results revealed that BPA administered for 45 days caused significant (p<0.05) and dose-dependent reduction in epididymis weight. There was significant (p<0.05) increase in lipid peroxidation and the acid phosphatase activity. Dose dependent reduction in protein, sialic acid contents, as well as the activity of enzymatic antioxidants and mitochondrial enzymes was recorded compared to vehicle treated group. The effect was dose-dependent. Histopathological alteration was observed. This study concludes that BPA causes toxicity in epididymis of mice by generating free radicals, which may be a possible reason for reduction in sperm parameters.