bluuebunny/crossref_metadata_2025_split huggingface dataset:
PenQuest: a gamified attacker/defender meta model for cyber security assessment and education
Authors: Luh Robert , Temper Marlies , Tjoa Simon , Schrittwieser Sebastian , Janicke Helge 
Published: November 2019

AbstractAttacks on IT systems are a rising threat against the confidentiality, integrity, and availability of critical information and infrastructures. At the same time, the complex interplay of attack techniques and possible countermeasures makes it difficult to appropriately plan, implement, and evaluate an organization’s defense. More often than not, the worlds of technical threats and organizational controls remain disjunct. In this article, we introduce PenQuest, a meta model designed to present a complete view on information system attacks and their mitigation while providing a tool for both semantic data enrichment and security education. PenQuest simulates time-enabled attacker/defender behavior as part of a dynamic, imperfect information multi-player game that derives significant parts of its ruleset from established information security sources such as STIX, CAPEC, CVE/CWE and NIST SP 800-53. Attack patterns, vulnerabilities, and mitigating controls are mapped to counterpart strategies and concrete actions through practical, data-centric mechanisms. The gamified model considers and defines a wide range of actors, assets, and actions, thereby enabling the assessment of cyber risks while giving technical experts the opportunity to explore specific attack scenarios in the context of an abstracted IT infrastructure. We implemented PenQuest as a physical serious game prototype and successfully tested it in a higher education environment. Additional expert interviews helped evaluate the model’s applicability to information security scenarios.
The Minnesota Model: A Clinical Assessment of Its Effectiveness in Treating Anxiety and Depression Compared to Addiction
Authors: Montague Hollie , Fairholm Ian 
Published: November 2019

AbstractThe current study compared and assessed the effectiveness of the Minnesota model in reducing psychological symptoms of anxiety and depression among two groups: individuals with clinically diagnosed addiction only (n = 29) and individuals with clinically diagnosed anxiety/depression in the absence of addiction (n = 25). Anxiety and depression were measured using the Generalised Anxiety Disorder 7 and the Patient Health Questionnaire 9, respectively. Two one-way analyses of covariance found no significant differences in post-intervention anxiety and depression scores when comparing the addiction group and the anxiety/depression group (F(1, 51) = 0.075, p = 0.786 and F(1, 51) = 0.302, p = 0.585, respectively). Reliable change index calculations also indicated that both the addiction group and the anxiety/depression group exhibited clinically significant reductions in anxiety and depression following treatment. These findings are considered in light of key methodological limitations, and the theoretical and therapeutic implications are discussed.
Management of Lipid Abnormalities in Patients with Diabetes
Authors: Sillars Anne , Sattar Naveed 
Published: November 2019

AbstractPurpose of ReviewTo describe lipid abnormalities in diabetes, when they occur and the evidence base for lipid management with established and new drugs to prevent diabetes complications. We also discuss how to manage statin intolerance.Recent FindingsStatins remain first-line therapy in patients with diabetes, though newer therapies to reduce LDL-C have emerged, including ezetimibe as an add-on therapy to statins, and injectable PCSK9 inhibitors, both of which are safe and effective in diabetes. Emerging evidence suggests a need to consider lipid-lowering therapies more often in younger patients with both type 1 and type 2 diabetes.SummaryStatins remain the cornerstone of lipid management in diabetes but other options are increasing. There is also now evidence for better managing apparent statin intolerance. Notably, younger patients lose the most life years from their diabetes, an observation that future guidelines need to consider.
Endothelial Cell-Specific Transcriptome Reveals Signature of Chronic Stress Related to Worse Outcome After Mild Transient Brain Ischemia in Mice
Authors: Wegner Stephanie , Uhlemann Ria , Boujon Valérie , Ersoy Burcu , Endres Matthias , Kronenberg Golo , Gertz Karen 
Published: November 2019

AbstractVascular mechanisms underlying the adverse effects that depression and stress-related mental disorders have on stroke outcome are only partially understood. Identifying the transcriptomic signature of chronic stress in endothelium harvested from the ischemic brain is an important step towards elucidating the biological processes involved. Here, we subjected male 129S6/SvEv mice to a 28-day model of chronic stress. The ischemic lesion was quantified after 30 min filamentous middle cerebral artery occlusion (MCAo) and 48 h reperfusion by T2-weighted MRI. RNA sequencing was used to profile transcriptomic changes in cerebrovascular endothelial cells (ECs) from the infarct. Mice subjected to the stress procedure displayed reduced weight gain, increased adrenal gland weight, and increased hypothalamic FKBP5 mRNA and protein expression. Chronic stress conferred increased lesion volume upon MCAo. Stress-exposed mice showed a higher number of differentially expressed genes between ECs isolated from the ipsilateral and contralateral hemisphere than control mice. The genes in question are enriched for roles in biological processes closely linked to endothelial proliferation and neoangiogenesis. MicroRNA-34a was associated with nine of the top 10 biological process Gene Ontology terms selectively enriched in ECs from stressed mice. Moreover, expression of mature miR-34a-5p and miR-34a-3p in ischemic brain tissue was positively related to infarct size and negatively related to sirtuin 1 (Sirt1) mRNA transcription. In conclusion, this study represents the first EC-specific transcriptomic analysis of chronic stress in brain ischemia. The stress signature uncovered relates to worse stroke outcome and is directly relevant to endothelial mechanisms in the pathogenesis of stroke.
Illicit/cheap cigarettes in South Africa
Authors: van der Zee Kirsten , van Walbeek Corné , Magadla Sibahle 
Published: November 2019

AbstractUsing wave 5 of the National Income Dynamics Study (conducted in 2017), this paper investigates the market for very low-priced cigarettes in South Africa, which, in all probability, are illicit. Since the sum of the excise tax and VAT in 2017 amounted to R16.30 (1.22 USD) per pack, any cigarettes selling for R20 (1.50 USD) per pack or less are likely to be illicit, assuming reasonable production costs. By this definition, approximately 30% of cigarettes consumed in South Africa in 2017 were illicit. Illicit cigarettes are found across all nine provinces. At the margin, the purchase of illicit cigarettes is associated with lower socio-economic characteristics, such as having lower levels of income and education. As illicit cigarettes undermine both the fiscal and health agendas of tobacco taxation policy, these results highlight the need for the South African government to implement urgently effective measures in order to curb illicit trade.
Combination Immunotherapy Strategies in Breast Cancer
Authors: Chun Brie M. , Page David B. , McArthur Heather L. 
Published: November 2019

AbstractPurpose of ReviewWe summarize combination immunotherapy strategies for the treatment of breast cancer, with a focus on metastatic disease. First, a general overview of combination approaches is presented according to breast cancer subtype. Second, additional review of promising combination approaches is presented.Recent FindingsCombination strategies utilizing chemotherapy or radiotherapy with immune checkpoint inhibition are being evaluated across multiple phase III trials. Dual immunotherapy strategies, such as dual immune checkpoint inhibition or combined co-stimulation/co-inhibition, have supportive preclinical evidence and are under early clinical investigation. Modulation of the immune microenvironment via cytokines and vaccination strategies, as well as locally focused treatments to enhance antigenic responses, are active areas of research.SummaryPre-clinical and translational research sheds new light on numerous ways the immune system may be modulated to fight against cancer. We describe current and emerging combination approaches which may improve patient outcomes in metastatic breast cancer.
An Overview of the Homozygous Cystic Fibrosis Transmembrane Conductance Regulator Mutation c.3700 A>G (p.Ile1234Val) in Qatar
Authors: Hammoudeh Samer , Gadelhak Wessam , AbdulWahab Atqah , Al-Langawi Mona , Janahi Ibrahim A. 
Published: November 2019

Abstract
Purpose of Review
Cystic fibrosis (CF) is a monogenic recessive disease with multisystem involvement. The cause is a mutation in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The aim is to review the literature involving the CFTR I1234V mutation and to provide recommendations for future research activities.

Recent Findings
The prevalence rates of CFTR mutations vary across the globe. The CFTR I1234V mutation is the most common mutation in Qatar, and one of the most common in the Arabian Gulf region.

Summary
Areas for future research include testing of the CFTR transcript and activity levels in different samples including nasal cells and organoids. Another area is applying Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology as a tool for gene editing.
Carbon-Cycle Feedbacks Operating in the Climate System
Authors: Williams Richard G. , Katavouta Anna , Goodwin Philip 
Published: November 2019

AbstractClimate change involves a direct response of the climate system to forcing which is amplified or damped by feedbacks operating in the climate system. Carbon-cycle feedbacks alter the land and ocean carbon inventories and so act to reduce or enhance the increase in atmospheric CO2 from carbon emissions. The prevailing framework for carbon-cycle feedbacks connect changes in land and ocean carbon inventories with a linear sum of dependencies on atmospheric CO2 and surface temperature. Carbon-cycle responses and feedbacks provide competing contributions: the dominant effect is that increasing atmospheric CO2 acts to enhance the land and ocean carbon stores, so providing a negative response and feedback to the original increase in atmospheric CO2, while rising surface temperature acts to reduce the land and ocean carbon stores, so providing a weaker positive feedback for atmospheric CO2. The carbon response and feedback of the land and ocean system may be expressed in terms of a combined carbon response and feedback parameter, λcarbon in units of W m− 2K− 1, and is linearly related to the physical climate feedback parameter, λclimate, revealing how carbon and climate responses and feedbacks are inter-connected. The magnitude and uncertainties in the carbon-cycle response and feedback parameter are comparable with the magnitude and uncertainties in the climate feedback parameter from clouds. Further mechanistic insight needs to be gained into how the carbon-cycle feedbacks are controlled for the land and ocean, particularly to separate often competing effects from changes in atmospheric CO2 and climate forcing.
Institutionalization risk and costs associated with agitation in Alzheimer's disease
Authors: Cloutier Martin , Gauthier‐Loiselle Marjolaine , Gagnon‐Sanschagrin Patrick , Guerin Annie , Hartry Ann , Baker Ross A. , Duffy Ruth , Gwin Keva , Sanon Aigbogun Myrlene ,   Alzheimer's Disease Neuroimaging Initiative
Published: November 2019

AbstractIntroductionAgitation in individuals with Alzheimer's disease (AD) may predict institutionalization. This study assessed the incremental risk and costs associated with agitation in individuals with AD.MethodsA retrospective analysis of the National Alzheimer's Coordinating Center Uniform Data Set (June 2005–February 2018) was conducted. Incremental risk of institutionalization associated with agitation was estimated and used with the number of institutionalized individuals with AD and agitation and costs of living by residential setting in the United States (literature‐based), to estimate incremental institutionalization costs.ResultsThe analysis included 11,348 individuals with AD: 6603 (58.2%) with and 4745 (41.8%) without agitation. Compared with individuals without agitation, those with agitation were 20% more likely to be institutionalized (odds ratio = 1.20; 95% CI = 1.08–1.33). Total incremental cost of institutionalization associated with agitation was $4.3 billion ($50,588/individual).DiscussionAgitation is associated with a higher risk of institutionalization among patients with AD, which translates into a substantial economic burden.
Nonpharmaceutical Interventions for Pandemic Influenza: Communication, Training, and Guidance Needs of Public Health Officials
Authors: Kenney Jasmine , Crumly Julie , Qualls Noreen 
Published: November 2019

ABSTRACTObjectives:The aim of this study was to identify the needs of state, tribal, local, and territorial (STLT) public health officials in communicating, implementing, and monitoring nonpharmaceutical interventions (NPIs) during an influenza pandemic.Methods:A Web-based survey collected data from a nonrandom sample of STLT health departments.Results:A total of 267 of 346 public health officials responded (77.2% response rate). STLTs identified the general public, families, childcare programs, K-12 schools, and workplaces as their priority audiences for NPI communication. Training needs included NPI decision-making strategies, triggers for implementing NPIs, and communicating NPI recommendations to families and communities, as well as a more practical orientation and real-world examples of how to incorporate NPI guidance into preparedness and response activities. Information is needed on health messaging for various populations and settings and on the legal authority for implementing specific NPIs.Conclusions:Future NPI recommendations by CDC should continue to be based on feedback solicited from STLT health departments. To fill identified gaps, CDC used these findings to create NPI guidance and materials to assist in prepandemic planning and preparedness for STLTs and various community settings.
Dietary choline supplementation attenuated high-fat diet-induced inflammation through regulation of lipid metabolism and suppression of NFκB activation in juvenile black seabream (Acanthopagrus schlegelii)
Authors: Jin Min , Pan Tingting , Tocher Douglas R. , Betancor Mónica B. , Monroig Óscar , Shen Yuedong , Zhu Tingting , Sun Peng , Jiao Lefei , Zhou Qicun 
Published: November 2019

AbstractThe present study aimed to investigate whether dietary choline can regulate lipid metabolism and suppress NFκB activation and, consequently, attenuate inflammation induced by a high-fat diet in black sea bream (Acanthopagrus schlegelii). An 8-week feeding trial was conducted on fish with an initial weight of 8·16 ± 0·01 g. Five diets were formulated: control, low-fat diet (11 %); HFD, high-fat diet (17 %); and HFD supplemented with graded levels of choline (3, 6 or 12 g/kg) termed HFD + C1, HFD + C2 and HFD + C3, respectively. Dietary choline decreased lipid content in whole body and tissues. Highest TAG and cholesterol concentrations in serum and liver were recorded in fish fed the HFD. Similarly, compared with fish fed the HFD, dietary choline reduced vacuolar fat drops and ameliorated HFD-induced pathological changes in liver. Expression of genes of lipolysis pathways were up-regulated, and genes of lipogenesis down-regulated, by dietary choline compared with fish fed the HFD. Expression ofnfκband pro-inflammatory cytokines in liver and intestine was suppressed by choline supplementation, whereas expression of anti-inflammatory cytokines was promoted in fish fed choline-supplemented diets. In fish that received lipopolysaccharide to stimulate inflammatory responses, the expression ofnfκband pro-inflammatory cytokines in liver, intestine and kidney were all down-regulated by dietary choline compared with the HFD. Overall, the present study indicated that dietary choline had a lipid-lowering effect, which could protect the liver by regulating intrahepatic lipid metabolism, reducing lipid droplet accumulation and suppressing NFκB activation, consequently attenuating HFD-induced inflammation inA. schlegelii.
Tectonism and volcanism enhanced by deglaciation events in southern Iceland
Authors: Van Vliet-Lanoë Brigitte , Bergerat Françoise , Allemand Pascal , Innocentd Christophe , Guillou Hervé , Cavailhes Thibault , Guðmundsson Águst , Chazot Gilles , Schneider Jean-Luc , Grandjean Philippe , Liorzou Celine , Passot Sophie 
Published: November 2019

AbstractSouthern Iceland is one of the main outlets of the Icelandic ice sheet and is subject to seismicity of both tectonic and volcanic origins along the South Iceland Seismic Zone (SISZ). A sedimentary complex spanning Marine Isotopic Stage 6 (MIS 6) to the present includes evidence of both activities. It includes a continuous sedimentary record since the Eemian interglacial period, controlled by a rapid deglaciation, followed by two marine glacioisostasy-forced transgressions, separated by a regression phase connected to an intra-MIS 5e glacial advance. This record has been constrained by tephrostratigraphy and dating. Analysis of this record has provided better insights into the interconnectedness of hydrology and volcanic and tectonic activity during deglaciations and glaciations. Low-intensity earthquakes recurrently affected the water-laid sedimentation during the early stages of unloading, accompanying rifting events, dyke injection, and fault reactivations. During full interglacial periods, earthquakes were significantly less frequent but of higher magnitude along the SISZ, due to stress accumulation, favored by low groundwater levels and more limited magma production. Occurrence of volcanism and seismicity in Iceland is commonly related to rifting events. Subglacial volcanic events seem moreover to have been related to stress unlocking related to limited or full unloading/deglaciation events. Major eruptions were mostly located at the melting margin of the ice sheet.
Educating Children, Civilizing Society: Missionary Schools and Non-European Teachers in South Dutch New Guinea, 1902–1942
Authors: Derksen Maaike 
Published: November 2019

AbstractThis article addresses the colonial project of “civilizing” and educating indigenous people in the farthest corners of the Dutch empire – South Dutch New Guinea (1902–1942), exploring the entanglement between colonial education practice and the civilizing mission, unravelling the variety of actors in colonial education in South Dutch New Guinea. Focusing on practice, I highlight that colonial education invested heavily in disciplining the bodies, minds, and beliefs of indigenous peoples to align them with Western Catholic standards. This observation links projects to educating and disciplining indigenous youth to the consolidation of colonial power. Central to these intense colonial interventions in the lives of Papuans were institutions of colonial education, managed by the Catholic mission but run by non-European teachers recruited from elsewhere in the Dutch colony. Their importance as proponents of the “civilizing mission” is largely unappreciated in the historiography of missionary work on Papua.
Kinematics-based end-effector path control of a mobile manipulator system on an uneven terrain using a two-stage Support Vector Machine
Authors: Jangid Hitesh , Jain Subham , Teka Beteley , Raja Rekha , Dutta Ashish 
Published: November 2019

SUMMARYA mobile manipulator system (MMS) consists of a robotic arm mounted on a mobile platform that is used in rescue and relief, space exploration, warehouse automation, etc. As the total system has 14 Degrees of Freedom (DOF), it does not have a closed-form inverse kinematics (IK) solution. A learning-based method is proposed, which uses the forward kinematics data to learn the IK relation for motion of an MMS on a rough terrain, using a one-class support vector machine (SVM) framework. Once trained, the model estimates the joint probability distribution of the MMS configuration and end-effector position. This distribution is used to find the MMS configuration for a given desired end-effector path. Past research using a Kohonen Self organizing map (KSOM) neural network-based open-loop control method has shown that the MMS deviates from its desired path while moving on an uneven terrain due to unknown disturbances such as wheel slip, slide, and terrain deformation. Therefore, a new sequential two-stage SVM-based end-effector path-tracking control scheme is proposed to control the end-effector path. In this scheme, the error in the end-effector path is continuously tracked with the help of a Microsoft Kinect 2.0 (Microsoft Regional Sales, Singapore 119968) and is sent as a feedback to the controller. Once the error reaches a threshold value, the error correction step of the controller gets activated to correct the error until the desired accuracy is reached. The effectiveness of the proposed approach is proved through extensive simulations and experiments conducted on 3D terrain in which it is shown that the end effector can follow the desired path with an average experimental error of around 2 cm between the desired and final corrected path.
Design-to-Workspace Synthesis of a Cable Robot Used in Legs Training Machine
Authors: Lamine Houssein , Romdhane Lotfi , Saafi Houssem , Bennour Sami 
Published: November 2019

SUMMARYThis paper deals with a continuous design task of a planar cable robot used in a gait training machine called the cable-driven legs trainer. The design of cable robots requires satisfying two constraints, that is, tensions in the cables must remain non-negative, and cable interferences should be avoided. The carried design approach is based on interval analysis, which is one of the most efficient methods to obtain certified results. The constraints of non-negative tensions and cable to end-effector interference are solved using interval analysis tools. By means of a dynamic simulation, the reached workspace and the produced wrenches of the cable robot are evaluated as a set of interval vectors. An optimization algorithm is then designed to optimize the cable robot structure for the gait training machine. The robot is designed to produce non-negative tensions in the cables and to avoid collision at all times within the desired workspace and under the required external loads.
Lower Assouad Dimension of Measures and Regularity
Authors: HARE KATHRYN E. , TROSCHEIT SASCHA 
Published: November 2019

AbstractIn analogy with the lower Assouad dimensions of a set, we study the lower Assouad dimensions of a measure. As with the upper Assouad dimensions, the lower Assouad dimensions of a measure provide information about the extreme local behaviour of the measure. We study the connection with other dimensions and with regularity properties. In particular, the quasi-lower Assouad dimension is dominated by the infimum of the measure’s lower local dimensions. Although strict inequality is possible in general, equality holds for the class of self-similar measures of finite type. This class includes all self-similar, equicontractive measures satisfying the open set condition, as well as certain “overlapping” self-similar measures, such as Bernoulli convolutions with contraction factors that are inverses of Pisot numbers.We give lower bounds for the lower Assouad dimension for measures arising from a Moran construction, prove that self-affine measures are uniformly perfect and have positive lower Assouad dimension, prove that the Assouad spectrum of a measure converges to its quasi-Assouad dimension and show that coincidence of the upper and lower Assouad dimension of a measure does not imply that the measure is s-regular.