bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of mental health measurement scales for evaluating the effects of mental health prevention interventions
Authors: Breedvelt Josefien J F , Zamperoni Victoria , South Emily , Uphoff Eleonora P , Gilbody Simon , Bockting Claudi L H , Churchill Rachel , Kousoulis Antonis A 
Published: December 2019

Abstract

Background
Consistent and appropriate measurement is needed in order to improve understanding and evaluation of preventative interventions. This review aims to identify individual-level measurement tools used to evaluate mental health prevention interventions to inform harmonization of outcome measurement in this area.

Methods
Searches were conducted in PubMed, PsychInfo, CINAHL, Cochrane and OpenGrey for studies published between 2008 and 2018 that aimed to evaluate prevention interventions for common mental health problems in adults and used at least one measurement scale (PROSPERO CRD42018095519). For each study, mental health measurement tools were identified and reviewed for reliability, validity, ease-of-use and cultural sensitivity.

Results
A total of 127 studies were identified that used 65 mental health measurement tools. Most were used by a single study (57%, N = 37) and measured depression (N = 20) or overall mental health (N = 18). The most commonly used questionnaire (15%) was the Centre for Epidemiological Studies Depression Scale. A further 125 tools were identified which measured non-mental health-specific outcomes.

Conclusions
There was little agreement in measurement tools used across mental health prevention studies, which may hinder comparison across studies. Future research on measurement properties and acceptability of measurements in applied and scientific settings could be explored. Further work on supporting researchers to decide on appropriate outcome measurement for prevention would be beneficial for the field.
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function
Authors: Flynn Mairéad , Whitton Laura , Donohoe Gary , Morrison Ciaran G , Morris Derek W 
Published: December 2019

Abstract
Mutations in genes that encode centrosomal/ciliary proteins cause severe cognitive deficits, while common single-nucleotide polymorphisms in these genes are associated with schizophrenia (SZ) and cognition in genome-wide association studies. The role of these genes in neuropsychiatric disorders is unknown. The ciliopathy gene SDCCAG8 is associated with SZ and educational attainment (EA). Genome editing of SDCCAG8 caused defects in primary ciliogenesis and cilium-dependent cell signalling. Transcriptomic analysis of SDCCAG8-deficient cells identified differentially expressed genes that are enriched in neurodevelopmental processes such as generation of neurons and synapse organization. These processes are enriched for genes associated with SZ, human intelligence (IQ) and EA. Phenotypic analysis of SDCCAG8-deficent neuronal cells revealed impaired migration and neuronal differentiation. These data implicate ciliary signalling in the aetiology of SZ and cognitive dysfunction. We found that centrosomal/ciliary genes are enriched for association with IQ, suggesting altered gene regulation as a general model for neurodevelopmental impacts of centrosomal/ciliary genes.
Dietary pterostilbene supplementation attenuates intestinal damage and immunological stress of broiler chickens challenged with lipopolysaccharide
Authors: Zhang Hao , Chen Yanan , Chen Yueping , Li Yue , Jia Peilu , Ji Shuli , Zhou Yanmin , Wang Tian 
Published: December 2019

Abstract
The present study explored the potential effect of pterostilbene as a prophylactic treatment on the lipopolysaccharide (LPS)-induced intestinal injury of broiler chickens by monitoring changes in mucosal injury indicators, redox status, and inflammatory responses. In total, 192 one-day-old male Ross 308 broiler chicks were randomly divided into four groups. This trial consisted of a 2 × 2 factorial design with a diet factor (supplemented with 0 or 400 mg/kg pterostilbene from 1 to 22 d of age) and a stress factor (intraperitoneally injected with saline or LPS at 5.0 mg/kg BW at 21 da of age). The results showed that LPS challenge induced a decrease in BW gain (P &lt; 0.001) of broilers during a 24-h period postinjection; however, this decrease was prevented by pterostilbene supplementation (P = 0.031). Administration of LPS impaired the intestinal integrity of broilers, as indicated by increased plasma diamine oxidase (DAO) activity (P = 0.014) and d-lactate content (P &lt; 0.001), reduced jejunal villus height (VH; P &lt; 0.001) and the ratio of VH to crypt depth (VH:CD; P &lt; 0.001), as well as a decreased mRNA level of jejunal tight junction protein 1 (ZO-1; P = 0.002). In contrast, pterostilbene treatment increased VH:CD (P = 0.018) and upregulated the mRNA levels of ZO-1 (P = 0.031) and occludin (P = 0.024) in the jejunum. Consistently, pterostilbene counteracted the LPS-induced increased DAO activity (P = 0.011) in the plasma. In addition, the LPS-challenged broilers exhibited increases in nuclear accumulation of nuclear factor kappa B (NF-κB) p65 (P &lt; 0.001), the protein content of tumor necrosis factor α (P = 0.033), and the mRNA abundance of IL-1β (P = 0.042) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3; P = 0.019). In contrast, pterostilbene inhibited the nuclear translocation of NF-κB p65 (P = 0.039) and suppressed the mRNA expression of IL-1β (P = 0.003) and NLRP3 (P = 0.049) in the jejunum. Moreover, pterostilbene administration induced a greater amount of reduced glutathione (P = 0.017) but a lower content of malondialdehyde (P = 0.023) in the jejunum of broilers compared with those received a basal diet. Overall, the current study indicates that dietary supplementation with pterostilbene may play a beneficial role in alleviating the intestinal damage of broiler chicks under the conditions of immunological stress.
Sustained Weight Loss and Risk of Breast Cancer in Women 50 Years and Older: A Pooled Analysis of Prospective Data
Authors: Teras Lauren R , Patel Alpa V , Wang Molin , Yaun Shiaw-Shyuan , Anderson Kristin , Brathwaite Roderick , Caan Bette J , Chen Yu , Connor Avonne E , Eliassen A Heather , Gapstur Susan M , Gaudet Mia M , Genkinger Jeanine M , Giles Graham G , Lee I-Min , Milne Roger L , Robien Kim , Sawada Norie , Sesso Howard D , Stampfer Meir J , Tamimi Rulla M , Thomson Cynthia A , Tsugane Shoichiro , Visvanathan Kala , Willett Walter C , Zeleniuch-Jacquotte Anne , Smith-Warner Stephanie A 
Published: December 2019

AbstractBackgroundExcess body weight is an established cause of postmenopausal breast cancer, but it is unknown if weight loss reduces risk.MethodsAssociations between weight change and risk of breast cancer were examined among women aged 50 years and older in the Pooling Project of Prospective Studies of Diet and Cancer. In 10 cohorts, weight assessed on three surveys was used to examine weight change patterns over approximately 10 years (interval 1 median = 5.2 years; interval 2 median = 4.0 years). Sustained weight loss was defined as no less than 2 kg lost in interval 1 that was not regained in interval 2. Among 180 885 women, 6930 invasive breast cancers were identified during follow-up.ResultsCompared with women with stable weight (±2 kg), women with sustained weight loss had a lower risk of breast cancer. This risk reduction was linear and specific to women not using postmenopausal hormones (&gt;2–4.5 kg lost: hazard ratio [HR] = 0.82, 95% confidence interval [CI] = 0.70 to 0.96; &gt;4.5–&lt;9 kg lost: HR = 0.75, 95% CI = 0.63 to 0.90; ≥9 kg lost: HR = 0.68, 95% CI = 0.50 to 0.93). Women who lost at least 9 kg and gained back some (but not all) of it were also at a lower risk of breast cancer. Other patterns of weight loss and gain over the two intervals had a similar risk of breast cancer to women with stable weight.ConclusionsThese results suggest that sustained weight loss, even modest amounts, is associated with lower breast cancer risk for women aged 50 years and older. Breast cancer prevention may be a strong weight-loss motivator for the two-thirds of American women who are overweight or obese.
Influence of cell wall polymers and their modifying enzymes during plant–aphid interactions
Authors: Silva-Sanzana Christian , Estevez José M , Blanco-Herrera Francisca 
Published: December 2019

AbstractAphids are a major issue for commercial crops. These pests drain phloem nutrients and transmit ~50% of the known insect-borne viral diseases. During aphid feeding, trophic structures called stylets advance toward the phloem intercellularly, disrupting cell wall polymers. It is thought that cell wall-modifying enzymes (CWMEs) present in aphid saliva facilitate stylet penetration through this intercellular polymer network. Additionally, different studies have demonstrated that host settling preference, feeding behavior, and colony performance of aphids are influenced by modulating the CWME expression levels in host plants. CWMEs have been described as critical defensive elements for plants, but also as a key virulence factor for plant pathogens. However, whether CWMEs are elements of the plant defense mechanisms or the aphid infestation process remains unclear. Therefore, in order to better consider the function of CWMEs and cell wall-derived damage-associated molecular patterns (DAMPs) during plant–aphid interactions, the present review integrates different hypotheses, perspectives, and experimental evidence in the field of plant–aphid interactions and discusses similarities to other well-characterized models such as the fungi–plant pathosystems from the host and the attacker perspectives.
NRT1.1s in plants: functions beyond nitrate transport
Authors: Wang Wei , Hu Bin , Li Aifu , Chu Chengcai 
Published: December 2019

AbstractArabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first nitrate transporter identified in plants and was initially found to play a role in nitrate uptake and transport. AtNRT1.1 also displays auxin transport activity and mediates nitrate-modulated root development, suggesting that it has transport capacity for multiple substrates. Subsequent work revealed that AtNRT1.1 can respond to environmental nitrate fluctuations by altering its nitrate transport activity, modulated by phosphorylation, leading to the critical finding that AtNRT1.1 acts as a transceptor for nitrate sensing. Recent studies have revealed how OsNRT1.1B, the functional homologue of AtNRT1.1 in rice, mediates nitrate signal transduction from the plasma membrane to the nucleus, and how OsNRT1.1B integrates the nitrate and phosphate signaling networks. OsNRT1.1B has also been shown to be involved in regulating the root microbiota to facilitate organic nitrogen mineralization in soil, thus mediating plant–microbe interactions. Furthermore, the divergent functions of OsNRT1.1A and OsNRT1.1B in regulating nitrogen use in rice suggest that the function of NRT1.1 is still far from fully understood. In this review, we focus on the most recent progress on the molecular mechanisms of NRT1.1s in plants, with the aim of providing an up-to-date view of the versatile functions of NRT1.1 in nitrogen utilization in plants.
William King, Sir William Petty, and Post-War Ireland (1690–92): Sir Robert Southwell and the Printing of Political Discourse
Authors: Hinds Peter 
Published: December 2019

Abstract
This article analyses the production of printed political discourse between post-war Ireland and England, in particular Sir Robert Southwell’s leading role in bringing to publication William King’s The State of the Protestants and Sir William Petty’s The Political Anatomy of Ireland in 1691. The questions these two books raised for the settlement of Ireland and for the relationship between the two kingdoms of Ireland and England have become very important for Anglo-Irish political history yet their publication circumstances in 1691 have not been considered. The article argues that studying these circumstances, applying the methods of book history, and analysing carefully reception contexts reveals the ways that senior government figures used print for political and personal influence, demonstrates the growing role and sophistication of printed discourse in Anglo-Irish politics, and uncovers how networks of trusted friends and allies operating between kingdoms could be crucial for the production and favourable reception of political argument in print.
Latex content in adult vaccines
Authors: Davenport Julie , Gomez Robert , Smith Derek 
Published: December 2019

Abstract

Introduction
Hypersensitivity reactions to natural rubber latex are well-characterized occupational concerns for health care personnel. Health care providers are at increased risk for exposure and possibly transmission of vaccine preventable diseases. Therefore, many health care facilities require providers to be vaccinated against these diseases to maintain employment. Mandatory vaccination for these health care providers presents potential challenges and safety concerns.

Materials and Methods
Using a commercial Latex Allergen ELISA Assay kit for Hev b 1, we evaluated the latex content of HAVRIX, ENGERIX-B, TWINRIX, and BOOSTRIX all manufactured by GlaxoSmithKline.

Results
These data demonstrate undetectable Hev b 1 content among all of the vaccines tested. This study provides the first known data regarding natural rubber latex content in adult vaccines.

Conclusions
Our study revealed undetectable levels of Hev b 1 natural rubber latex content in the tested adult vaccines. These data provide evidence for prospective studies into the safety of vaccinating latex allergic patients.
Multiple Sclerosis Exacerbation Associated With High-Altitude Climbing Exposure
Authors: Hsieh David T , Warden Graham I , Butler Jay M , Nakanishi Erika , Asano Yuri 
Published: December 2019

Abstract
The spectrum of the neurological effects of high-altitude exposure can range from high-altitude headache and acute mountain sickness, to the more severe end of the spectrum with high-altitude cerebral edema. In general, patients with known unstable preexisting neurological conditions and those patients with residual neurological deficits from a preexisting neurological condition are discouraged from climbing to high altitudes because of the risk of exacerbation or worsening of symptoms. Although multiple sclerosis exacerbations can be triggered by environmental factors, high-altitude exposure has not been reported as a potential trigger. We are reporting the case of a multiple sclerosis exacerbation presenting in an active duty U.S. Air Force serviceman upon ascending and descending Mt. Fuji within the same day.
A Cross-Sectional Examination of the Association Between Social Media Use and Sleep Among a Sample of U.S. Army Soldiers
Authors: Hill Christopher G , Beymer Matthew R , Jarvis Brantley P , Smith Jacob D , Nichols Jerrica N , Mysliwiec Vincent , Pecko Joseph A , Watkins Eren Youmans 
Published: December 2019

AbstractIntroductionIn the United States (U.S.), approximately 35% of adults sleep less than 7 hours per night. The relationship between social media use and insufficient sleep has not thoroughly been examined among adults. The purpose of this study was to determine if social media use is associated with insufficient sleep among a sample of U.S. Army Soldiers.MethodsThis study surveyed 9,052 U.S. Soldiers in 2018 via a self-administered online questionnaire. Using multivariable logistic regression, we examined the association between social media use (&lt;38 hours vs. ≥38 hours per week) and insufficient sleep, controlling for demographic and behavioral covariates.ResultsOverall, 54.9% of Soldiers reported insufficient sleep. There was no significant relationship between excessive social media use and insufficient sleep in the multivariable logistic regression (OR: 1.03; CI: 0.87–1.23). The covariates of sex, race/ethnicity, rank, hazardous alcohol consumption, anxiety, and depression were significantly associated with insufficient sleep. Soldiers who reported symptoms of anxiety were more than twice as likely (OR: 2.11; CI: 1.65–2.70) to report insufficient sleep than Soldiers without signs of anxiety. Additionally, Soldiers who reported depressive symptoms were 85% (OR: 1.85; CI: 1.44–2.37) more likely to experience insufficient sleep than Soldiers without signs of depression.ConclusionSufficient sleep is essential to ensuring mission readiness and preventing accidental morbidity and mortality among Soldiers. The findings of this analysis do not suggest a link between extended social media use and insufficient sleep. However, though previously uninvestigated, Soldiers reporting symptoms of anxiety and depression were more likely to experience insufficient sleep compared to unafflicted Soldiers. Therefore developing a culture that encourages Soldiers to seek necessary behavioral health screening and care could be a key primary strategy to promote adequate sleep.
On the origin of the asymmetric dwarf galaxy distribution around andromeda
Authors: Wan Zhen , Oliver William H , Lewis Geraint F , Read Justin I , Collins Michelle L M 
Published: December 2019

ABSTRACT
The dwarf galaxy distribution surrounding M31 is significantly anisotropic in nature. Of the 30 dwarf galaxies in this distribution, 15 form a disc-like structure and 23 are contained within the hemisphere facing the Milky Way. Using a realistic local potential, we analyse the conditions required to produce and maintain these asymmetries. We find that some dwarf galaxies are required to have highly eccentric orbits in order to preserve the presence of the hemispherical asymmetry with an appropriately large radial dispersion. Under the assumption that the dwarf galaxies originate from a single association or accretion event, we find that the initial size and specific energy of that association must both be relatively large in order to produce the observed hemispherical asymmetry. However if the association was large in physical size, the very high-energy required would enable several dwarf galaxies to escape from the M31 and be captured by the Milky Way. Furthermore, we find that associations that result in this structure have total specific energies concentrated around $E = V_{\rm esc}^{2} - V_{\rm init}^{2} \sim 200^2$ – $300^2\ \rm {km^2\ s^{-2}}$, implying that the initial velocity and initial position needed to produce the structure are strongly correlated. The overlap of initial conditions required to produce the radial dispersion, angular dispersion, and the planar structure is small and suggests that either they did not originate from a single accretion event, or that these asymmetric structures are short-lived.
Ultracompact H ii regions with extended emission: the complete view
Authors: de la Fuente Eduardo , Porras Alicia , Trinidad Miguel A , Kurtz Stanley E , Kemp Simon N , Tafoya Daniel , Franco José , Rodríguez-Rico Carlos 
Published: December 2019

ABSTRACT
In this paper, we present the results of a morphological study performed on a sample of 28 ultracompact H ii (UC H ii) regions located near extended free–free emission, using radio continuum (RC) observations at 3.6 cm with the C and D Very Large Array (VLA) configurations, with the aim of determining a direct connection between them. By using previously published observations in B and D VLA configurations, we compiled a final catalogue of 21 UC H ii regions directly connected with the surrounding extended emission (EE). The observed morphology of most of the UC H ii regions in RC emission is irregular (single- or multipeaked sources) and resembles a classical bubble structure in the Galactic plane with well-defined cometary arcs. RC images superimposed on colour composite Spitzer images reinforce the assignations of direct connection by the spatial coincidence between the UC components and regions of saturated 24 μm emission. We also find that the presence of EE may be crucial to understand the observed infrared excess because an underestimation of ionizing Lyman photons was considered in previous works (e.g. Wood & Churchwell; Kurtz, Churchwell & Wood).
Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
Authors: Mladenov Emil , Staudt Christian , Soni Aashish , Murmann-Konda Tamara , Siemann-Loekes Maria , Iliakis George 
Published: December 2019

AbstractIn vertebrates, genomic DNA double-strand breaks (DSBs) are removed by non-homologous end-joining processes: classical non-homologous end-joining (c-NHEJ) and alternative end-joining (alt-EJ); or by homology-dependent processes: gene-conversion (GC) and single-strand annealing (SSA). Surprisingly, these repair pathways are not real alternative options restoring genome integrity with equal efficiency, but show instead striking differences in speed, accuracy and cell-cycle-phase dependence. As a consequence, engagement of one pathway may be associated with processing-risks for the genome absent from another pathway. Characterization of engagement-parameters and their consequences is, therefore, essential for understanding effects on the genome of DSB-inducing agents, such as ionizing-radiation (IR). Here, by addressing pathway selection in G2-phase, we discover regulatory confinements in GC with consequences for SSA- and c-NHEJ-engagement. We show pronounced suppression of GC with increasing DSB-load that is not due to RAD51 availability and which is delimited but not defined by 53BP1 and RAD52. Strikingly, at low DSB-loads, GC repairs ∼50% of DSBs, whereas at high DSB-loads its contribution is undetectable. Notably, with increasing DSB-load and the associated suppression of GC, SSA gains ground, while alt-EJ is suppressed. These observations explain earlier, apparently contradictory results and advance our understanding of logic and mechanisms underpinning the wiring between DSB repair pathways.
Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs
Authors: Meyer Britta , Immer Carina , Kaiser Steffen , Sharma Sunny , Yang Jun , Watzinger Peter , Weiß Lena , Kotter Annika , Helm Mark , Seitz Hans-Michael , Kötter Peter , Kellner Stefanie , Entian Karl-Dieter , Wöhnert Jens 
Published: December 2019

AbstracttRNAs from all domains of life contain modified nucleotides. However, even for the experimentally most thoroughly characterized model organism Escherichia coli not all tRNA modification enzymes are known. In particular, no enzyme has been found yet for introducing the acp3U modification at position 47 in the variable loop of eight E. coli tRNAs. Here we identify the so far functionally uncharacterized YfiP protein as the SAM-dependent 3-amino-3-carboxypropyl transferase catalyzing this modification and thereby extend the list of known tRNA modification enzymes in E. coli. Similar to the Tsr3 enzymes that introduce acp modifications at U or m1Ψ nucleotides in rRNAs this protein contains a DTW domain suggesting that acp transfer reactions to RNA nucleotides are a general function of DTW domain containing proteins. The introduction of the acp3U-47 modification in E. coli tRNAs is promoted by the presence of the m7G-46 modification as well as by growth in rich medium. However, a deletion of the enzymes responsible for the modifications at position 46 and 47 in the variable loop of E. coli tRNAs did not lead to a clearly discernible phenotype suggesting that these two modifications play only a minor role in ensuring the proper function of tRNAs in E. coli.