bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated assessment of cerebral blood flow and cerebrovascular reactivity based on functional tests data in patients with Parkinson’s disease and vascular pathology
Authors: Bayborodina I. V. , Zavadovskaya V. D. , Zhukova N. G. , Zorkaltsev M. A. , Zhukova I. A. 
Published: July 2020

Objective. To evaluate cerebral blood flow parameters and cerebrovascular reactivity indices based on data of functional tests in patients with Parkinson’s disease (PD) and vascular pathology.Material and Methods. A total of 148 people were examined, divided into 4 groups: (1) main group comprised 24 patients with idiopathic PD; (2) comparison group 1 included 21 patients with vascular parkinsonism; (3) comparison group 2 included 26 patients with a diagnosis of chronic cerebral ischemia of severity degree 2 with no signs of parkinsonism; and (4) comparison group 3 included 77 patients with PD and cerebrovascular disease. All patients received transcranial duplex scanning of cerebral blood vessels (TCD) through the temporal window (Toshiba Aplio 500, Japan, 2–2.5 MHz sector probe) using standard protocols for the assessment of blood flow velocity characteristics. An assessment of cerebrovascular reactivity (reserve) was performed using the diagnostic and treatment complex “Carbonic”. The range of cerebrovascular and vasomotor hypercapnia reactivity to hypercapnia was evaluated in the “Testing of cerebrovascular reactivity” mode.Results. A comprehensive study of cerebral blood flow parameters using functional tests suggested that the absence of changes in the cerebrovascular reactivity index (VRhyperCO2 ) observed in patients with idiopathic PD may be considered a differential diagnostic criterion for Parkinson’s disease and cerebrovascular pathology with Parkinson’s symptoms.
Correlations of the parameters of cardiopulmonary bypass and hemodynamics during cardiac surgery and the structural and functional state of the retina
Authors: Diakova M. L. , Podoksenov Yu. K. , Shipulin V. M. , Shishneva E. V. , Kamenshchikov N. O. , Krivosheina O. I. , Denisko M. S. 
Published: July 2020

Objective. To study the structural and functional retinal changes developed in cardiac surgery patients as a consequence of cardiopulmonary bypass and to identify the factors aff ecting the nature and extent of changes observed.Material and Methods. Ten patients who underwent cardiac surgery under cardiopulmonary bypass (CPB) were studied. The ophthalmologic examination was performed before cardiac surgery and 10–14 days after the surgery.Results. On days 10 to 14, after cardiac surgery, visual acuity was restored to the maximum; the perimetry indicators, the level of intraocular pressure, and the structures of the anterior segment of the eyeballs did not change signifi cantly. The ophthalmoscopy revealed the foci of ischemic edema in the fundus along with the fi rst- and second-order arteries in 30% of cases. The thickness of ganglionic and nerve fi ber layers decreased in one patient (10%), which may be associated with the intraoperative ischemia of orbital artery branches feeding the optic nerve. These changes had direct relationships with the level of maximum mean blood pressure (MBP) during CPB and the fl uctuation of absolute MBP values during CPB: MBP ≥ 90 mmHg during CPB was associated with the occurrence of ischemic foci in the retina in 100% of cases. If the diff erence between the maximum and minimum MBP levels during CPB exceeded 20 mmHg, the changes in the retina occurred more frequently (p = 0.0350) than in the cases where MBP fl uctuations during CPB were less than 20 mmHg.Conclusions. The most signifi cant changes in the vision organs of patients undergoing cardiac surgery under CPB occur in the retina. Factors associated with the occurrence of pathological ischemic changes in the retina were fl uctuations in MBP during CPB (≥20 mmHg) and the absolute value of maximum MBP during CPB (>90 mmHg).
The role of β-adrenergic receptors in stress-induced cardiac injury in a rat model of Takotsubo syndrome
Authors: Kurbatov B. K. , Prokudina E. S. 
Published: July 2020

Introduction. The pathophysiological mechanisms of cardiac injury in Takotsubo syndrome are currently poorly understood. The role of adrenergic receptor (AR) subtypes in the development of stress-induced myocardial injury (SIMI) remains unclear.Aim. To assess the role of β-ARs in the development of SIMI.Material and Methods. The study was performed using female Wistar rats (n = 84). Rats were subject to 24-hour immobilization in the supine position to simulate SIMI. 99mTc-pyrophosphate radiopharmaceutical was used to determine the degree of cardiac injury.Results. The study showed that β-AR blockade with propranolol reduced the degree of cardiac injury by 38.4%. Selective β1- AR antagonists, atenolol and nebivolol, led to 2.00- and 2.55-fold decreases in 99mTc pyrophosphate accumulation in the heart, respectively. Blockade of β2-ARs by a selective antagonist ICI-118.551 caused an increase in the degree of 99mTc-pyrophosphate accumulation in the heart by 34.6%. A selective β3-AR antagonist L-748337 did not affect 99mTc pyrophosphate accumulation in the heart.Conclusions. The study showed that β1-ARs are involved in the damaging effects of stress on the heart during immobilization stress. β2-AR had a cardioprotective effect in immobilization. β3-AP did not play a significant role in the stress-induced cardiac injury with a single exposure to the stressor.
Cardiovascular pathology in the clinical practice of primary care physicians on the example of Krasnoyarsk
Authors: Khramchenko M. A. , Karpenkova A. D. , Petrova M. M. , Kaskaeva D. S. 
Published: July 2020

Introduction. Cardiovascular comorbidity is a relevant problem in modern medicine. Comorbid pathology significantly worsens the quality of life and increases the likelihood of death in cardiovascular patients. The combination of diseases requires a comprehensive examination of the patient and the choice of optimal therapy. This work reviews the structure of cardiovascular comorbidity in outpatient patients of Krasnoyarsk, analyzes the most frequently prescribed medications, and makes conclusions about the need to highlight the problems of combined pathologies in outpatient practice.Aim. To study the structure of cardiovascular comorbidity in outpatient patients in the city of Krasnoyarsk, to assess the frequency of comorbid pathologies in cardiovascular patients, and to analyze the extent of the prescribed therapy.Material and Methods. A one-stage retrospective study analyzed 1,928 ambulatory medical charts of cardiovascular patients who visited the primary care physicians in the polyclinics of Krasnoyarsk in 2018. The material was statistically processed, and diff erences were considered statistically significant at p < 0.05.Results. The prevalence of comorbid pathologies in cardiovascular patients reached 87% and tended to rise with the patients’ age. The study showed that coronary heart disease (CHD) and obesity were associated with type 2 diabetes mellitus (T2DM) in agreement with results reported in previous studies. 43.2% of patients achieved a blood pressure level (BP) < 140/80 mm Hg while on antihypertensive therapy. 46.8% of patients achieved total cholesterol (TCh) < 5.0 mmol/L while taking statins. Only 18.5% of T2DM patients and 15.9% of patients with chronic kidney disease (CKD) who were taking statins had TCh < 4.5 mmol/L. Heart rate (HR) < 70 bpm was reached in about 40% of patients taking b-blockers.Conclusions. Comorbidity prevalence among cardiovascular patients of Krasnoyarsk city was high and tended to increase with the increase in patient age. Arterial hypertension (AH) and T2DM was the most frequent combination among patients with cardiovascular diseases (CVD). Administered antiplatelet, hypolipidemic, and antihypertensive therapies did not fully comply with the current clinical recommendations in regard to the regimen of administration, dosage, and rates of the treatment targets achieved. The study showed that cardiovascular diseases are most frequently combined with T2DM. In this regard, it is necessary to promote the population awareness of the primary and secondary prevention of these comorbid diseases.
The manifestation of obesity paradox in patients with myocardial infarction and various systolic dysfunctions: Myth or reality?
Authors: Sedykh D. Yu. , German A. I. , Khryachkova O. N. , Kashtalap V. V. , Barbarash O. L. 
Published: July 2020

Objective. To identify the relationships between obesity and prognosis in patients after myocardial infarction within three years of observation, depending on the severity of post-infarction systolic myocardial dysfunction.Material and Methods. The study design was based on a three-year follow-up retrospective analysis of patients from the register of acute coronary syndrome of Kemerovo city in 2015 (n = 1366). The main clinical outcomes, including death from all causes, recurrent myocardial infarction (RIM), cerebral stroke, hospitalization for unstable angina pectoris (UA), and decompensation of heart failure (HF), were assessed taking into account the initial values of the left ventricular (LV) ejection fraction (EF) in the groups of obese or non-obese patients who suffered from myocardial infarction. Obesity was defined based on body mass index (BMI).Results. General obesity was detected in 282 patients (32.2%) at the time of myocardial infarction. Obesity did not adversely affect myocardial infarction outcomes in the general group of patients during the three-year follow up, but it was associated, as a protective factor, with the number of hospitalizations for UA only in patients with BMI ≥35 kg/m2 . Additional stratification of patients by LV EF showed a paradox of obesity and a decrease in systolic myocardial function from 41 to 49% in the group of patients with myocardial infarction and BMI-estimated general obesity. There was a significant decrease in the all-cause mortality rate within three years of observation in the obese patients with initially severe systolic dysfunction compared with that in patients with systolic dysfunction and initial BMI of less than 30 kg/m2 .Conclusion. The presence of general obesity did not affect the development of an unfavorable outcome in the general group of patients within three years after myocardial infarction, with the exception of non-obese patients with severe systolic dysfunction who had the highest rate of total mortality. Regardless of the degree of post-infarction systolic myocardial dysfunction, obesity can be protective in regard to the development of UA in patients with a BMI greater than or equal to 35 kg/m2 .
The role of proinflammatory cytokines in the development of anthracycline-induced heart failure
Authors: Teplyakov A. T. , Shilov S. N. , Popova A. A. , Berezikova E. N. , Grakova E. V. , Neupokoeva M. N. , Kopeva K. V. , Ratushnyak E. T. , Stepachev E. I. 
Published: July 2020

Objective. To study the pathogenetic and prognostic role of cytokines (tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)) in the development of anthracycline-induced chronic heart failure (CHF).Material and Methods. A total of 176 women with breast cancer who received anthracycline antibiotics as a part of polychemotherapy regimens were examined. Upon examination, the patients in remission were divided into two groups within 12 months after the completion of chemotherapy: patients with the development of cardiotoxic remodeling (group 1, n = 52) and women with preserved cardiac function (group 2, n = 124). All patients received echocardiography study before, during, and after chemotherapy. Biochemical blood tests were done to determine the levels of TNF-α and IL-1β before chemotherapy, immediately after it, and 12 months after chemotherapy completion. Determination of polymorphisms of the TNF-α (–308G/A, rs1800629) and IL-1β genes (+3953, rs1143634) was carried out by polymerization chain reaction.Results. A higher level of TNF-α and IL-1β in group 1 was associated with the development of heart failure 12 months after the end of chemotherapy. The level of TNF-α over 7.5 pg/mL after the completion of chemotherapy allowed to predict the development of cardiovascular complications in women receiving anthracycline therapy with sensitivity of 44.2% and specificity of 75.8% (AUS = 0.600; 95% CI = 0.524–0.673; p = 0.035). The study did not reveal any significant differences in the frequency distribution for genotypes of 308G/A polymorphism (rs1800629) of the TNF-α gene and +3953 (rs1143634) polymorphism of the IL-1β gene in the studied groups.Conclusion. Patients with breast cancer who developed anthracycline-induced heart failure 12 months after the end of chemotherapy had the increased levels of TNF-α and IL-1β suggesting the pathogenetic role of proinflammatory cytokines in the development of cardiac injury during anthracycline therapy.
Clinical significance and prospects of using ST2 in isсhemic heart failure patients
Authors: Grakova E. V. , Kopeva K. V. , Teplyakov A. T. , Svarovskaya A. V. , Ogurkova O. N. , Soldatenko M. V. , Astafurova O. E. , Garganeeva A. A. 
Published: July 2020

Objective: The objective of this study is to assess the role of soluble ST2 (sST2) in developing adverse cardiovascular events (ACE) and fatal outcomes in patients with chronic heart failure (HF) during 18 [12.5; 35.5]-month follow-up period.Results. Depending on the median of baseline sST2 levels, all patients were retrospectively divided into two groups: group 1 enrolled patients with sST2 levels < 31.5 ng/mL (n = 22); and group 2 comprised patients with sST2 levels ≥ 31.5 ng/mL (n = 26). In group 1, the sST2 levels were 27.27 [23.94; 29.23] ng/mL, which was 33.9% higher (p < 0.0000001) than in group 2 (41.28 [34.86; 50.17] ng/mL). ACEs were registered in 9 cases (40.9%) in group 1 and in 17 cases (65.4%) in group 2 (p = 0.025). Based on ROC-analysis, baseline ST2 levels ≥ 33.53 ng/mL were considered a biomarker to predict an unfavorable course of ischemic heart failure during 18 [12.5; 35.5] months of follow-up period with sensitivity of 78.9% and specificity of 62.2% (AUC 0.719; 95% CI 0.562–0.845; p = 0.0059).Conclusion. The baseline sST2 levels may be considered a non-invasive biomarker allowing to predict the development of adverse cardiovascular events (ACE) and fatal outcomes in patients with chronic heart failure (HF) during 18 [12.5; 35.5] months of follow-up in addition to traditional risk factors.
The risk of developing chronic heart failure in patients with hypertension depending on the actual arterial stiffness
Authors: Chernyavina A. I. , Koziolova N. A. 
Published: July 2020

Objective. To determine the risk of developing chronic heart failure (CHF) in patients with hypertension (HTN) depending on the actual arterial stiffness.Material and Methods. The study included 175 patients with HTN without a verified diagnosis of heart failure. The average age was 48.5 ± 6.8 years. Patients underwent general clinical examination, volume sphygmoplethysmography assessments of cardio-ankle vascular index (CAVI), echocardiography study (left ventricular (LV) ejection fraction, LV diastolic function, LV myocardial mass index, indexed LV volume by echocardiography), and tests for serum N-terminal pro-B-type natriuretic peptide (NT-proBNP). Patients were divided into two groups depending on CAVI. Group 1 included 141 (80.6%) patients with CAVI < 9; group 2 included 34 (19.4%) patients with CAVI > 9.Results. In patients of group 1, the level of NT-proBNP was 0.008 [0.006; 5.770], which was significantly lower than the corresponding value in group 2, where the level of NT-proBNP was 13.08 [0.01; 350.65] ng/mL (p = 0.041). Indicators of odds ratio (OR) and relative risk (RR) were also significant. The chance of developing CHF with CAVI > 9 increased by almost 7 times (OR = 6.9; 95% CI = 2.8–16.8), and OR of CHF onset was 4.1 (95% CI = 2.2–7.6). Sensitivity and specificity rates were 55.9% and 84.4%, respectively. Correlation analysis revealed a medium degree of dependence and direct relationships between NT-proBNP level and CAVI values (r = 0.35; p <0.05).Conclusion. Serum level of NT-proBNP depended on the actual arterial stiffness. Patients with CAVI > 9 indicative of an increase in true arterial stiffness had a greater risk of developing heart failure assessed based on the level of NT-proBNP in the blood. Further studies are required to assess the effects of arterial stiffness, registered within the intermediate values of CAVI index, on the risk of heart failure onset.
THE USE OF TRANSLATION IDEOLOGY AND TECHNIQUES IN INDONESIAN VERSION OF AGATHA CHRISTIE’S ENDLESS NIGHT NOVEL
Authors: Pahrul Hadi Muhammad Zaki , Suhendra Erwin , Miswaty Titik Ceriyani 
Published: July 2020

Abstract
Translation is a process of transfering source text into the target text viewed from the equivalent of meaning, with equvalencies, the message in the translation text will be the same as the target text. Hence, translating is not just the process of tranfering text from the source language into the target language. However, instead of ideas, translation enters compilation, he processes a translation product. The use of appropriate translation techniques also affects the quality of the translation results. This study aims to describe the ideology of translation in Indonesian Version of Agatha Christie’s Endless Night Novel. The method used in this research is descriptive qualitative. The data of this study are qualitative based on types of words, phrases and sentences containing translation techniques and ideology taken from the translated novel of Indonesian Version of Agatha Christie’s Endless Night Novel. Based on the analysis of translation techniques and the ideology of translation used in the text, the ideology used in the translation text is foreignization. Based on the analysis, the results of the study show that of the 18 translation techniques, 12 translation techniques were found consisting of; Literal translation (53%), Amplification (11%), Variation (8%), Particularization (6%), Borrowing (6%), Transposition (5%), Reduction (4%), Calque (2%), Compensation (2%). Meanwhile Description, Linguistic Compression, and Established Equivalent occur only in (1%). The result of the study shows that the most dominant technique used in Indonesian version of Agatha Christie’s endless night novel is Literal translation with 82 occurrences frequency or 53%.
DESIGNING LIFE SKILL – BASED ENGLISH READING MATERIALS FOR SECOND GRADE STUDENTS OF SMA NEGERI 1 PRINGGASELA
Authors: Sutarman Sutarman , Saputra Ari , Syamsurrijal Syamsurrijal 
Published: July 2020

This research aims to: developing life skill-based English reading materials design for the second grade students of SMA NEGERI 1 PRINGGASELA. The design used in this research is report design by using R&D ( Research and Development ) approach. The subjects of this research are the second grade students of SMA Negeri 1 Pringgasela in academic year 2016/2017. There are 35 students. In collecting data, the researcher uses two steps. First, the researcher distributed questionnaires into the students. Second, the researcher gathers data for conducting evaluation, opinion and suggestion from an English Teacher of SMAN 1 Pringgasela and an expert of designed materials. All responses and comments to the open questions were reviewed and grouped into some meaningful categories as they provide useful information for revising the product.
To determine the readability level of the texts used in new developed reading materials, the following are the categories of readability level and reader grade level according to Flesch Readability East Formula and Flesch-Kincaid Grade Level. Scores between 90.0 and 100.0, considered easily understandable. Scores between 60.0 and 70.0, considered easily understood. Scores between 0.0 and 30.0, considered easily understood.
The final product of the materials consists of a course material of Life Skill Based English Material and a teacher’s manual. Whole Language Reading provides rich input of reading strategies, variety of topics, concepts, texts, activities, tasks, and evaluations. Using this material makes reading more holistic and meaningful as it provides integration across language skills and subject areas.
Educational institutions need to provide a rich learning environment with a variety of reading sources, print and digital to provide opportunities for students to choose and determine reading materials that suit their needs.
Pelatihan Manajemen Rekam Medis dan Informasi Kesehatan di Puskesmas Weru Kabupaten Sukoharjo
Authors: Hakam Fahmi 
Published: July 2020

Dengan meningkatkan kualitas tenaga perekam medis pada sarana pelayanan kesehatan, sehingga mampu melakukan pengumpulan data secara komunikatif. Selain itu juga mampu melakukan pendataan secara benar, melakukan analisis kuantitatif-kualitatif, perbaikan tata kelola manajemen unit kerja rekam medis sesuai dengan standar yang berlaku. Sehingga dapat menghasilkan sumber informasi dalam menghasilkan informasi kesehatan yang akurat. Kegiatan pengabdian masyarakat ini, bertujuan untuk meningkatkan pengetahuan dan kompetensi tenaga perekam medis di puskesmas, serta ada perbaikan manajemen pengelolaan rekam medis di puskesmas. Dalam Pengabdian Kepada Masyarakat ini tim pelaksana menggunakan analisa studi dan pemberian intervensi (pelatihan) kepada petugas rekam medis di Puskesmas, yang dilakukan dengan dua tahap, yaitu: 1) Menggambarkan karakteristik mitra, permasalahan dan kebutuhan dari tenaga rekam medis di Puskesmas. 2) Memberikan intervensi berupa pelatihan tentang manajemen unit kerja rekam medis (UKRM). Metode pelatihan dilakukan dengan interaktif, penyampaian materi (Teori dan Praktik) dan mengukur kemampuan peserta dengan : Pre-Test dan Post-Test, serta melakukan monitoring dan evaluasi pemberian pelatihan. Hasil dari pelaksanaan pengabdian di puskesmas weru : 1) Petugas puskesmas sudah semakin memahami pengelolaan dan manajemen UKRM di puskesmas. 2) Masih banyak ditemukan permasalahan duplikasi No.RM, kurangnya monitoring kualitas dan kelengkapan. 3) Pelaksanaan kegiatan ini mendapat respon yang baik dari kepala puskesmas dan para peserta yang merupakan petugas di UKRM