bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leistungs- und Abrechnungsdatum in GKV-Routinedaten: Umgang mit
zeitlichen Abweichungen
Authors: Ditscheid Bianka , Storch Josephine , Krause Markus , Meyer Ingo , Freytag Antje 
Published: December 2019

Zusammenfassung
Ziel Ziel dieser Untersuchung ist es, das aus dem Auseinanderfallen von
Leistungs- und Abrechnungsdatum in Krankenkassenroutinedaten resultierende
Risiko von Fehleinschätzungen der Inanspruchnahme in verschiedenen
Leistungsbereichen (ambulante ärztliche Behandlung, Arzneimittel, Heil-
und Hilfsmittel, Krankenhaus) in Bezug zum Tod als Indexereignis sowie in Bezug
zum Jahreswechsel zu quantifizieren, Erklärungsansätze
darzulegen und mögliche Lösungsstrategien aufzuzeigen.
Methodik In einem Wissenschaftlichen Data Warehouse einer großen
deutschen Krankenkasse standen vorstrukturierte Daten von in 2016 verstorbenen
Versicherten zur Verfügung. Die Darstellung zeitlicher Abweichungen von
Leistungs- und Abrechnungsdaten erfolgte für verschiedene ambulante und
stationäre Versorgungsbereiche unter Heranziehung von Daten der Jahre
2015 bis 2017. Ein exaktes Abrechnungsdatum (TT/MM/JJJJ) war
lediglich bei Heil- und Hilfsmittelverordnungen verfügbar. Bei
Arzneimittel-Verordnungen war das Abrechnungsdatum lediglich monatsgenau
(MM/JJJJ). Bei ambulanten ärztlichen Leistungen lag nur das
Abrechnungsquartal vor (Q/JJJJ).
Ergebnisse Die Analysen zeigen, dass im Leistungsbereich der ambulanten
ärztlichen Behandlung und der Krankenhausbehandlung <1%
der Fälle/Gebührenordnungspositionen (GOP)/OPS
nach dem Tod abgerechnet wurden, im Bereich der Heil- und Hilfsmittel jedoch
28–31% der Verordnungen (VO). Ein Großteil der
Leistungsabrechnungen nach dem Tod erfolgte innerhalb von 3 Monaten (93%
der Heil- und Hilfsmittel, 67% der ambulanten ärztlichen
Behandlungsfälle). Über den Jahreswechsel 2015/2016
zeigte sich eine zeitliche Differenz bei <1% der ambulanten GOP
bis hin zu 18% bei den Heilmittel-VO. Auch hier wurde die Mehrzahl der
Leistungen innerhalb der ersten 3 Monate nach dem Jahreswechsel abgerechnet
(100% der Heil- und Hilfsmittel, 65% der ambulanten GOP).
Schlussfolgerung Der zeitliche Verzug zwischen Leistungs- und
Abrechnungsdaten stellt bei Analysen der GKV-Leistungsinanspruchnahme bis zum
Tod eines Versicherten sowie beim Jahreswechsel eine Herausforderung dar und ist
eine Quelle für Unter-/Überschätzungsfehler. So
ist bei Datenanforderung, -aufbereitung und -auswertung explizit darauf zu
achten, dass auch noch nach dem zu betrachtenden Zeitraum abgerechnete
Leistungen berücksichtigt werden.
Management of Patients Symptomatically Unresponsive to Levothyroxine:
Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and
Liothyronine? A Research Priority
Authors: Heald Adrian , Livingston Mark , Hughes Dyfrig 
Published: December 2019

AbstractAround 5–10% of hypothyroid patients continue to experience
profound and sometimes disabling symptoms, including fatigue, depression and
impaired cognition, in spite of being adequately replaced biochemically. The use
of the combination of levothyroxine and liothyronine and natural desiccated
thyroid extract is controversial for reasons of costs, a lack of evidence of
additional benefit over levothyroxine alone, and potential safety concerns.
Clinical guidelines caution against the use of both, and advise that only in
exceptional cases may a short trial be considered. Natural desiccated thyroid
extract is not licensed for use in the UK. However, key deficiencies in the
existing evidence-base together with improved understanding of the pharmacology
of levothyroxine resistance, indicates that now is the right time for a
definitive clinical trial to address this important area of uncertainty.
Langwirksame Buprenorphinpräparate als neue pharmakologische
Option bei Opiatabhängigkeit
Authors: Soyka Michael 
Published: December 2019

ZusammenfassungDie Opioidsubstitution mit Methadon (oral) oder Buprenorphin (sublingual) ist
eine etablierte weltweit praktizierte First-Line-Behandlung der
Opiatabhängigkeit. Beide Substanzen müssen täglich oder
zumindest alle 2 Tage (Buprenorphin) gegeben werden. Langwirksame Opioide
standen zur Substitution nicht zur Verfügung. Das ändert sich
jetzt mit dem bereits zugelassenen, wöchentlich oder monatlich subkutan
injizierbaren Buprenorphin Depot CAM 2038 (Buvidal®), dem
monatlich zu applizierenden Depotpräparat RBP-6000 (Sublocade™)
und dem 6-Monate wirkenden Buprenorphin Depot-Implantat (Probuphine™).
Klinische Befunde und mögliche Indikationen dieser Medikamente werden
diskutiert.
Pineal Parenchymal Tumor with Intermediate Differentiation—A Case Report and Review of Literature from Rural India
Authors: Kumar Raj , Dayal Seema , Krishna Mani 
Published: December 2019

AbstractPineal gland tumors are rare tumors. According to World Health Organization (WHO) classification (2016) of the central nervous system, pineal parenchymal tumors of intermediate differentiation (PPTID) occupied their position between pineocytoma and pineoblastoma. It is either grade II or III. There are small numbers of reported cases, so its classification is still a matter of controversy. Here, we report a case of a 35-year-old man who presented with complaints of headache, nausea, vomiting, and focal weakness for 1 year. Computed tomography revealed an enhancing mass lesion in the region of pineal gland along with hydrocephalus. Following operation, histopathology of excised specimen was done, and it showed cellular tumor. Cells were having larger nuclei, vesicular chromatin pattern, ample cytoplasm, focal neuropil-like stroma along with moderate atypia, 3 to 5 mitotic figures per 10 hpf (high-power field), marked vascular proliferation, and pseudo rosette. Immunohistochemistry was found strongly positive for glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE), variable for synaptophysin, and negative for neurofilament and epithelial membrane antigen (EMA). These findings confirmed the diagnosis. As this tumor is rare with uncertain behavior following available treatment, the case report of PPTID grade III large cell type may enrich the existing data and is being presented because of its rarity.
Left Atrial to Femoral Artery Full Cardiopulmonary Bypass: A Novel Technique for Descending and Thoracoabdominal Aortic Surgery
Authors: Papanikolaou Dimitra , Savio Chris , Zafar Mohammad A. , Freudzon Leon , Wu Jinlin , Abdelbaky Mohamed , Pelletier Keith J. , Buntin Joelle , Faggion Vinholo Thais , Ziganshin Bulat A. , Schwartz Brian , Elefteriades John A. 
Published: December 2019

AbstractLeft atrial-femoral artery (LA-FA) bypass with a centrifugal pump and no oxygenator is commonly used for descending and thoracoabdominal aortic (DTAA) operations, mitigating the deleterious effects of cross-clamping. We present our initial experience performing DTAA replacement under LA-FA (left-to-left) cardiopulmonary bypass (CPB) with an oxygenator. DTAA replacement under LA-FA bypass with an oxygenator was performed in 14 consecutive patients (CPB group). The pulmonary vein and femoral artery (or distal aorta) were cannulated and the full CPB machine were used, including oxygenator, roller pump, pump suckers, and kinetically enhanced drainage. The CPB group was compared with 50 consecutive patients who underwent DTAA replacement utilizing traditional LA-FA bypass without an oxygenator (LA-FA group). Perioperative data were collected and statistical analyses were performed. All CPB patients maintained superb cardiopulmonary stability. The pump sucker permitted immediate salvage and return of shed blood. Superb oxygenation was maintained at all times. High-dose full CPB heparin was reversed without difficulty. The CPB group required markedly fewer blood transfusions than the LA-FA group (2.21 vs. 5.88 units, p < 0.004). The 30-day mortality rate was 7.1% (n = 1) and there were no paraplegia cases in the CPB group versus 7 (14%) deaths and 3 (6%) paraplegia cases in the LA-FA group. Traditional LA-FA bypass without an oxygenator avoids high-dose heparin. In the present era, heparin reversal is more secure. Our experience finds that the novel application of LA-FA CPB with an oxygenator is safe and suggests improved hemodynamics (immediate return of shed blood) and a hemostatic advantage (avoidance of loss of coagulation factors in the cell saver).
AGE–RAGE Stress in the Pathophysiology of Atrial Fibrillation and Its Treatment
Authors: Prasad Kailash 
Published: December 2019

AbstractAtrial fibrillation (AF) is the most common of cardiac arrhythmias. Mechanisms such as atrial structural remodeling and electrical remodeling have been implicated in the pathogenesis of AF. The data to date suggest that advanced glycation end products (AGEs) and its cell receptor RAGE (receptor for AGE) and soluble receptor (sRAGE) are involved in the pathogenesis of AF. This review focuses on the role of AGE–RAGE axis in the pathogenesis of AF. Interaction of AGE with RAGE generates reactive oxygen species, cytokines, and vascular cell adhesion molecules. sRAGE is a cytoprotective agent. The data show that serum levels of AGE and sRAGE, and expression of RAGE, are elevated in AF patients. Elevated levels of sRAGE did not protect the development of AF. This might be due to greater elevation of AGE than sRAGE. Measurement of AGE–RAGE stress (AGE/sRAGE) would be appropriate as compared with measurement of AGE or RAGE or sRAGE alone in AF patients. AGE and its interaction with RAGE can induce AF through alteration in cellular protein and extracellular matrix. AGE and its interaction with RAGE induce atrial structural and electrical remodeling. The treatment strategy should be directed toward reduction in AGE levels, suppression of RAGE expression, blocking of binding of AGE to RAGE, and elevation of sRAGE and antioxidants. In conclusion, AGE–RAGE axis is involved in the development of AF through atrial structural and electrical remodeling. The treatment modalities for AF should include lowering of AGE, suppression of RAGE, elevation of sRAGE, and use of antioxidants.
The psychology of guns: risk, fear, and motivated reasoning
Authors: Pierre Joseph M. 
Published: December 2019

AbstractThe gun debate in America is often framed as a stand-off between two immutable positions with little potential to move ahead with meaningful legislative reform. Attempts to resolve this impasse have been thwarted by thinking about gun ownership attitudes as based on rational choice economics instead of considering the broader socio-cultural meanings of guns. In this essay, an additional psychological perspective is offered that highlights how concerns about victimization and mass shootings within a shared culture of fear can drive cognitive bias and motivated reasoning on both sides of the gun debate. Despite common fears, differences in attitudes and feelings about guns themselves manifest in variable degrees of support for or opposition to gun control legislation that are often exaggerated within caricatured depictions of polarization. A psychological perspective suggests that consensus on gun legislation reform can be achieved through understanding differences and diversity on both sides of the debate, working within a common middle ground, and more research to resolve ambiguities about how best to minimize fear while maximizing personal and public safety.
CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
Authors: Jacków Joanna , Guo Zongyou , Hansen Corey , Abaci Hasan E. , Doucet Yanne S. , Shin Jung U , Hayashi Ryota , DeLorenzo Dominick , Kabata Yudai , Shinkuma Satoru , Salas-Alanis Julio C. , Christiano Angela M. 
Published: December 2019

Significance
This study demonstrates a therapeutic option using induced pluripotent stem cells (iPSCs), gene editing, and tissue engineering techniques for the development of a long-lasting treatment that will result in the permanent closure of nonhealing wounds in dystrophic epidermolysis bullosa (DEB), especially for recessive DEB (RDEB). Here, we demonstrated that the combination of iPSCs, gene editing, and tissue engineering allows us to perform efficient gene correction by homology-directed repair with the CRISPR-Cas9 gRNA ribonucleoprotein complex system, differentiate the gene-corrected RDEB patient iPSCs into skin cells, and generate human skin equivalents (HSEs) that show skin integrity and type VII collagen restoration after grafting them onto nude mice. The results from this study serve as a foundation to translate this treatment into the clinic.
The γ-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization inArabidopsis
Authors: Miao Huiying , Guo Rongfang , Chen Junlin , Wang Qiaomei , Lee Yuh-Ru Julie , Liu Bo 
Published: December 2019

Significanceγ-Tubulin is essential for eukaryotic cells to produce new microtubules that are assembled into arrays like mitotic spindles, and its function depends on proteins that form complexes with it. In centrosome-lacking cells, the generation of new microtubules is dependent on formation of the γ-tubulin ring complex (γTuRC). Our experiments reveal γ-tubulin–dependent but γTuRC-independent phenomena of microtubule generation during mitotic cell division in the plants that lack the centrosome. We conclude that the γTuRC plays a critical role in spindle pole organization, but that plant cells still complete cell division in its absence. Therefore, this work in plant cells advances our knowledge of acentrosomal microtubule organization in general.
Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria
Authors: Light Samuel H. , Méheust Raphaël , Ferrell Jessica L. , Cho Jooyoung , Deng David , Agostoni Marco , Iavarone Anthony T. , Banfield Jillian F. , D’Orazio Sarah E. F. , Portnoy Daniel A. 
Published: December 2019

Significance
Strategies of energy metabolism are variable across the microbial world and fundamentally reflect distinct ecological dynamics. The complex electron transfer mechanisms that support many such processes take place in the cell membrane but can be wired to the exterior of the cell in some circumstances. The results presented here reveal a family of extracellular reductases that possess a post-translationally flavinylated sequence motif. This motif provides a conserved framework that mediates electron transfer from the membrane to different extracellular small molecules. These findings advance our understanding of microbial energy metabolism and identify a generalized and modular electron transfer strategy that could be exploited for applications in metabolic engineering.
Do Prescription Drug Monitoring Programs Encourage Prescription – or Illicit – Opioid Abuse?
Authors: Meadowcroft Devon , Whitacre Brian 
Published: December 2019

Background Prescription drug monitoring programs (PDMPs) are tools that states can use to fight prescription opioid misuse within their jurisdiction. However, because PDMPs make prescription opioids more difficult to access, these programs may have the unintended consequence of increasing deaths related to illicit opioids. Methods This study uses fixed effects models to estimate how PDMP regulatory strength is associated with both prescription opioid- and heroin-related deaths between 1999 and 2016. PDMP regulatory strength is measured by creating a score using multiple correspondence analysis (MCA). Additional models replace the MCA score with a binary indicator for the presence of one particular regulation requiring physicians to access the system before writing opioid prescriptions. Results Results show that continuous measures of PDMP strength are not generally associated with prescription opioid- or heroin-related death rates. Yet, one model does show that PDMP scores are positively associated with the heroin-related death rate. The models using the binary mandatory access variable show a strong positive association with both prescription opioid and heroin deaths. Conclusions This study supports the theory that more stringent state PDMPs are associated with higher rates of heroin-related deaths, potentially due to decreases in prescription opioid availability.
A Cross-Cell Interleaved Nonlinear Lattice for Potential NSLS-II Upgrade
Authors: Li Yongjun , He An , Shaftan Timur , Smaluk Victor , Kosciuk Bernard , Bai Zhenghe , Wang Lin 
Published: December 2019

Abstract
An interleaved sextupole scheme using a cross-cell betatron phase cancellation technique is adopted as a candidate for a future upgrade to the NSLS-II lattice. The upgraded lattice will use as many NSLS-II installed magnets as possible, including 30 dipoles, which will create a triple bend achromat configuration. A 300 pm-rad horizontal beam emittance has already been achieved with the current configuration. The emittance can be further reduced to around 200 pm-rad with damping wigglers. Some new design concepts used in modern 4th-generation light sources, such as adopting longitudinal gradient bends and reverse bends, are incorporated into the design as well. The betatron phase-advance between sextupoles is designed to have a cross-cell interleaved cancellation pattern in the transverse planes. The dynamic aperture is sufficient to allow the conventional off-axis top-off injection. At the same time, a large energy acceptance looks promising and would ensure a sufficiently long beam lifetime.
A General Comparison On Impedance Theory And Cst Simulation of Discontinuities
Authors: Khosravi N. , Akhyani M. , Ahmadi E. , Mashal A. , Karimi H. , Dastan S. 
Published: December 2019

Abstract
Inhomogeneity of vacuum chamber components is the main source of coupling impedance. Nowadays, wake impedances are mostly predictable by 3D codes and analytical prediction of impedance theories can be helpful as a side solution. On the other hand, some asymmetries in the geometry of components might make troubles and lead to imprecise numerical results in 3D simulations. Analytical approximation of discontinuities, holes and grooves can give us an estimation of expected results and can be used as a benchmark in the case that we do not have any experimental data.
To clarify the validity of theoretical expressions, general discontinuities are simulated in CST Particle Studio. The comparison of final results is presented here. At last, Resistive Wall impedance and some general discontinuities of components at ILSF storage ring are compared form the theoretical and simulation point of view.
Synchrotron Radiation Reflections in the CLIC Beam Delivery System
Authors: Arominski D. , Latina A. , Sailer A. , Schulte D. 
Published: December 2019

Abstract
Synchrotron radiation (SR) reflction is an important issue for future linear colliders. High fluxes of SR might impact the performance of the detector, through irradiation of the forward luminosity and beam quality calorimeters or of the innermost layers of the vertex detector. The photon reflections depend on the beam pipe apertures' size, their shape, and materials used with various surface roughness. In this work, we present a study of SR including reflection for the 380GeV and 3 TeV beam parameters and optics of the Compact Linear Collider's Final Focus System. The simulations of the SR reections using the Synrad+ software are presented and the impact on the detector is discussed.
SixTrack Version 5: Status and New Developments
Authors: De Maria R. , Andersson J. , Berglyd Olsen V.K. , Field L. , Giovannozzi M. , Hermes P.D. , Høimyr N. , Iadarola G. , Kostoglou S. , Maclean E.H. , McIntosh E. , Mereghetti A. , Molson J. , Pellegrini D. , Persson T. , Schwinzerl M. , Dalena B. , Pugnat T. , Zacharov I. , Sjobak K.N. 
Published: December 2019

Abstract
SixTrack Version 5 is a major SixTrack release that introduces new features, with improved integration of the existing ones, and extensive code restructuring. New features include dynamic-memory management, scattering-routine integration, a new initial-condition module, and reviewed post-processing methods. Existing features like on-line aperture checking and Fluka-coupling are now enabled by default. Extensive performance regression tests have been developed and deployed as part of the new-release generation. The new features of the tracking environment developed for the massive numerical simulations will be discussed as well.
Frequency Map Measurements at the TPS
Authors: Chen C H , Chiu M S , Chen J Y , Tseng F H , Chen B Y , Huang B Y , Hsu T W , Lin W Y , Kuo C C , Tsai H J , Liu Y C , Chou P J 
Published: December 2019

Abstract
The Taiwan Photon Source (TPS) has been operated now for several years since its successful commissioning in December 2014 and has achieved reliable routine operation up to 500 mA with more than 10 hrs beam lifetime. Dynamic aperture (DA) measurements and associated frequency map analyses (FMA) at the TPS reveal beam dynamics behavior with and without insertion devices. A preliminary study based on turn-by-turn beam position monitor (BPMs) is presented in this paper.
An analytic approach to emittance growth from the beam- beam effect with applications to the LHeC
Authors: Nissen E , Schulte D 
Published: December 2019

Abstract
In colliders with asymmetric rigidity such as the proposed Large Hadron electron Collider, jitter in the weaker beam can cause emittance growth via coherent beam-beam interactions. The LHeC in this case would collide 7 TeV protons on 60 GeV electrons, which can be modeled using a weak-strong model. In this work we estimate the proton beam emittance growth by separating out the longitudinal angular kicks from an off-center bunch interaction and produce an analytic expression for the emittance growth per turn in systems like the LHeC.
Improving high precision cam mover’s stiffness
Authors: Kemppinen J , Mainaud Durand H , Herty A 
Published: December 2019

Abstract
Pre-alignment is a key challenge of the Compact Linear Collider (CLIC) study. The requirement for CLIC main beam quadrupole (MBQ) alignment is positioning to within 1 μm from target in 5 degrees of freedom (DOF) with ± 3mm travel. After motion, the position should be kept passively while the system's fundamental frequency is above 100Hz. Cam movers are considered for the task. Traditionally they are used for the alignment of heavier magnets with lower accuracy and stiffness requirement. This paper presents a new CLIC prototype cam mover with design emphasis on the fundamental frequency. A finite element method (FEM) model predicts the mode shapes and eigenfrequencies of the system and can be used for further improving the design. Experimental modal analysis (EMA) of the prototype shows that the prototype's fundamental frequency is at 44Hz. It also validates the FEM model.
Collimation of target induced halo following MAGIX at MESA
Authors: Ledroit B , Aulenbacher K 
Published: December 2019

Abstract
The Mainz Energy-recovering Superconducting Accelerator (MESA) will be an electron accelerator allowing operation in energy-recovery linac (ERL) mode. It provides the opportunity to operate scattering experiments at energies of ~ 100 MeV with thin gas-targets. The MESA Internal Gas Target Experiment (MAGIX) aims to operate windowless jet targets and different gases up to Xenon to search for possible dark photon interactions, to precisely measure the magnetic proton radius and astrophysical S-factors. Investigations on the impact of the target on beam dynamics and beam losses are required for machine safety and to examine limits to ERL operation. The goal of this work is to understand target induced halo in the different experimental setups, track halo particles through downstream sections to examine beam losses and include a suitable collimation system and shielding into the accelerator layout to protect the machine from direct and indirect damage through beam losses and radiation. The present status of the investigations is presented.