bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of MicroRNA Transcriptomes Insights into the miR-148a-3p Inducer of Rumen Development in Goats
Authors: Zhong Tao , Wang Cheng , Hu Jiangtao , Chen Xiaoyong , Niu Lili , Zhan Siyuan , Wang Linjie , Cao Jiaxue , Li Li , Zhang Hongping 
Published: July 2020

Abstract
Background: Rumen is an important digestive organ of ruminant. From fetal to adult stage, the morphology, structure and function of rumen have changed significantly. But the intrinsic genetic regulation is still limited. We previously reported a genome-wide expression profile of miRNAs in prenatal goat rumens. In the present study, we rejoined analyzed the transcriptomes of rumen miRNAs during prenatal (E60 and E135) and postnatal (D30 and D150) stages.Results: A total of 66 differentially expressed miRNAs (DEMs) were identified in the rumen tissues from D30 and D150 goats. Of these, 17 DEMs were consistently highly expressed in the rumens at the preweaning stages (E60, E135 and D30), while down-regulated at D150. Noteworthy, annotation analysis revealed that the target genes regulated by the DEMs were mainly enriched in MAPK signaling pathway, Jak-STAT signaling pathway and Ras signaling pathway. Interestingly, the expression of miR-148a-3p was significantly high in the embryonic stage and down-regulated at D150. The potential binding sites between miR-148a-3p and QKI were predicted by the TargetScan and verified by the dual luciferase report assay. The co-localization of miR-148a-3p and QKI was observed not in intestinal tracts but in rumen tissues by in situ hybridization. Moreover, the expression of miR-148a-3p in the epithelium was significantly higher than that in the other layers, suggesting that miR-148a-3p involve in the development of rumen epithelial cells by targeting QKI. Subsequently, miR-148a-3p inhibitor was found to induce the proliferation of GES-1 cells.Conclusions: Taken together, these results identified the DEMs involved in the development of rumen and provided an insight into the regulation mechanism of goat rumens during development.
Sociodemographic correlates of antenatal care visits in Nepal: Results from Nepal Demographic and Health Survey 2016
Authors: Adhikari Mukesh , Chalise Binaya , Bista Bihungum , Pandey Achyut Raj , Upadhyaya Dipak Prasad 
Published: July 2020

Abstract
Background: Good quality antenatal care visits are crucial to reduce maternal mortality and improve overall maternal and neonatal health outcomes. A previous study on antenatal care visits analyzed the nationally representative data of 2011; however, no studies have been conducted recently in Nepal. Therefore, we analyzed the sociodemographic correlates of the frequency and quality of antenatal care among Nepalese women from the nationally representative data of 2016.Methods: We analyzed data obtained from the Nepal Demography Health Survey (2016) on antenatal care for 2761 women who had one or more births in the past three years. Our study defined 'good quality antenatal care' as at least a 75% score on a composite metric which was obtained by adding the weighted scores assigned to the twelve recommended components of antenatal care. We analyzed the factors associated with the frequency and quality of antenatal care by using multiple Poisson regression and multiple logistic regression.Results: While 70 % of the Nepalese women surveyed had at least four antenatal care visits, only 21 % of these women received good-quality antenatal care. We found that the educated women (APR: 1.12; CI: 1.05-1.19) and the women of rich wealth index (APR: 1.27; CI: 1.18-1.37) were more likely to receive a higher number of antenatal visits. In contrast, women living in rural areas (APR: 0.92; CI: 0.87-0.98), and those who had more than two children (APR: 0.88; CI: 0.83-0.93) were less likely to receive a higher number of antenatal visits. Regarding the quality of antenatal care, educated women (AOR: 1.51; CI: 1.09-2.08), women who had educated husbands (AOR: 2.11; CI: 1.38-3.22), women of rich wealth index (AOR: 1.58; CI: 1.13-2.20) and women who had intended pregnancy (APR: 1.69; CI: 1.23-2.34), were more likely to receive good-quality antenatal care.Conclusion: Due to a wide variation in the coverage of different components of antenatal care, concerned stakeholders could tailor the interventions by focusing on components with lower use. Because we found an association of myriad sociodemographic factors with the frequency and quality of antenatal care, targeted interventions are necessary.
Gestational diabetes mellitus in pregnancy increased erythropoietin level affecting differentiation potency of haematopoietic stem cell of umbilical cord blood
Authors: Nordin Fazlina , Idris Mohd Razif Mohd , Mahdy Zaleha Abdullah , Wahid S Fadilah Abd 
Published: July 2020

Abstract
Background The in utero environment has many factors that can support cell differentiation. Cytokines, chemokines and growth factors play big roles in haematopoietic mechanisms. Some diseases like gestational diabetes mellitus (GDM) might affect the environment and haematopoietic stem cell (HSC) quality. The aim of this study is to investigate the adverse effects of GDM on umbilical cord blood (UCB) HSC in terms of differentiation potency including the UCB parameters used for banking and transplantation purposes. Methods UCB-HSC was isolated and further enriched using immuno-magnetic separation beads (MACS). The UCB-HSC were cultured in methylcellulose media to investigate the differentiation potency. The level of erythropoietin (EPO) and insulin in the UCB plasma was measured using enzyme linked immunoassay (ELISA) technique. Results The UCB parameters; volume, total nucleated count (TNC) and total CD34+ cells were significantly reduced in the GDM group compared to the control group. The number of HSC progenitors’ colonies were significantly reduced in the GDM group except for progenitor BFU-E, which was significantly increased (GDM=94.19 ± 6.21, Control=73.61 ± 2.73, p=0.010 ). This data was associated with higher EPO level in GDM group. However, the insulin level in the GDM group was comparable to the Control group. Conclusion Our results suggest that the changes in the in utero environment due to abnormalities during pregnancy such as GDM affect the differentiation potency of UCB-HSC. These findings can be considered as an additional parameter for the inclusion and exclusion criteria for UCB banking, particularly for mothers with GDM.
Energy Management of a PV-SB HPGS Based on Model Predictive Control
Authors: Algabalawy Mostafa , Samir Nesreen M. 
Published: July 2020

Abstract
Background

Hybrid Power Generation Systems (HPGSs) always introduces the solutions for many problems of the power systems such as; poor power quality and the highly generation costs. Usually, these systems have high opportunity of utilizing the renewable sources, where they are installed so near to the customers. In some times, the customers whom have installed these systems, have the ability to purchase or sell the required or the surplus energy, respectively. Therefore, the concept of the energy management should be implemented in these situations, which means providing energy to the consumers while respecting the demand and optimizing the production cost. Supplying power has become more and more complex in a growing network. Several ways exist to adapt to the steadily increasing energy demand. The energy efficiency of the buildings/generators could be improved, or new electric supply units could be built. However, smarter techniques of managing the grid from the demand side receive an increasing attention by research and industry for a promising economic potential.
Methods

The proposed HPGS in this paper is the combination of the Photovoltaic (PV) and the Storage Battery (SB). The Demand Response (DR) is the main philosophy for the energy management for PV-SB HPGS, while the Model Predictive Control (MPC) is applied to control the energy from the HPGS to the smart home, which was incorporated with an electrical heater in each room. The DR strategy has also been applied using other control techniques, such as thermostat and Proportional-Integral (PI) controller, for the purpose of comparing between the techniques.
Results

Simulation results for the three controllers were implemented. A comparison between the results was carried out. to verify the proposed system, which proved the superiority of the MPC.
Conclusions

A smart method for optimizing the comfort temperature inside the rooms by using a MPC strategy with a PV panel and a battery was proposed. DR allowed benefits on both system operation and market efficiency. MPC evidenced to provide economic benefits with respect to other compared controllers.
Neuregulin-1 Inhibits CoCl2-Induced Excitatory Amino Acid Carrier 1 Overexpression and Oxidative Stress in SH-SY5Y Cells
Authors: Kim Han-Byeol , Yoo Ji-Young , Yoo Seung-Yeon , Lee Jun-Ho , Kim Hye-Sun , Baik Tai-Kyoung , Woo Ran-Sook 
Published: July 2020

Abstract
Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl2 is not only a hypoxia-mimetic reagent but also an oxidative stress inducer. Here, we found that CoCl2 induced significant overexpression of EAAC1 in a dose- and time-dependent manner. We further demonstrated that pretreatment with NRG1 rescued the CoCl2-induced upregulation of EAAC1 and tau expression. Neuregulin-1 (NRG1) plays a protective role in the CoCl2-induced accumulation of reactive oxygen species (ROS) and reduction in antioxidative enzyme (SOD and Gpx) activity. Moreover, NRG1 attenuated CoCl2-induced apoptosis and cell death. NRG1 inhibited the CoCl2-induced release of cleaved caspase-3 and reduction in Bcl-XL. Our novel findings suggest that NRG1 may play a protective role in oxidative stress and hypoxia through the regulation of EAAC1.
Solar drying in the vineyard: a sustainable technology for the recovery of nutrients from winery organic waste
Authors: Prenafeta-Boldú F. X. , Burgos L. , Noguerol J. , Mercader M. , Soler J. , Fernández B. 
Published: July 2020

Abstract
The present study describes a pilot-scale experimental validation of a forced-convection greenhouse solar dryer, combined with a biofilter, for controlled atmospheric emissions. This set-up was applied to the dewatering of sewage sludge from a biological plant that treated process wastewater in a commercial Mediterranean winery. Experiments were performed after the harvest, from September onwards, during the peak generation of sludge. The average drying rate during the first 10 days of operation ranged from 1.17 to 2.24 kg m−2 d−1, depending on the measurement method, during which the water content of the sludge was reduced from 90% down to 67%. Biofiltration was quite inefficient against greenhouse gases (methane and dinitrous oxide), and direct emissions during the drying process were on average 57 g CO2-eq m−2 d−1. Ammonia and volatile organic compounds were removed with average efficiencies of 71% and 35%, but ammonia losses through volatilization represented less than 2% of the initial nitrogen content. The sludge was dried further during November, to the lowest possible water content of 14%. Both the intermediate and final sludge dried materials were characterized for their agronomical value as organic fertilizers.
Transparency of public expenditure accountability in municipal governments: a case study in the State of Goiás
Authors: Celma Duque Ferreira  , Gilberto Crispim  , Fabrícia Silva da Rosa  , Luiz Alberton  
Published: July 2020

Objective: To identify the municipalities of Goiás that comply with the legal provisions of the Fiscal Responsibility Law (LRF) regarding the transparency of public management accounts from January 2010 to December 2018.
Methodology: With descriptive characteristics, the study carried out consultations on websites of city halls, Federal Audit Courts (TCU), States and the National Treasury Secretariat (STN). Data collection was carried out by means of a check-list built based on current legal provisions, and electronic mails to those responsible for advertising in each municipality when the data was not found. Descriptive statistics was used as an analysis tool, as well as Pearson and Spearman's correlation coefficient and Chi-Square (Pearson association).
Results: It was concluded that there is no uniformity of information among the municipalities, despite the eighteen years after the promulgation of the LRF; Goiás municipalities partially comply with legal requirements; there are municipalities that do not have their own website and do not provide an access link to the transparency portal on their homepages; there are municipalities that do not publish budget planning instruments (PPA, LDO and LOA), as well as accountability for the realization of revenue and the execution of budget expenditures. In some cases, difficulties were encountered in identifying the link on the transparency portal on their homepages, and so it was decided to send e-mail to those responsible asking about the results.
Contributions: The study contributes to the government of the state of Goiás, which is why it funded the research through the Goiás State Research Support Foundation (FAPEG); for the specific literature, because it presents an empirical study on regulations with more than eighteen years of effect and encourages discussion for future research.
Country comparative assessment of Islamic banks' financial economic situation
Authors: Tariq Jarbou  , Jorge Katsumi Niyama  
Published: July 2020

Purpose: Promote a country comparative assessment of the Islamic banks economic and financial situation.
Methodology: We used a descriptive and documentary analytical approach. We collected data on Islamic bank financial indicators in 21 countries and analyzed it in light of the standards recommended by the Islamic Financial Services Board (IFSB) and the Basel Committee on Banking Supervision (BCBS). The sample consisted of all countries with available data in the IFSB database (PSIFIs). Data refers to the second quarter of 2018 grouped by countries. We used a simple descriptive statistic, in figures form, to analyze the collected data.
Results: This document points out that 90% of Islamic financial institutions (IFIs) in the sample calculate the capital adequacy ratio (CAR) according to BCBS recommendations. In addition, 95% have CARs above 8% (the minimum set by BCBS and IFSB). Therefore, 95% of countries have secure financial systems in terms of bank solvency. In terms of asset quality, the Islamic financial system in Oman showed the best quality in managing its resources. Sudan has shown the highest ratios of profitability in its Islamic banks. In the liquidity analysis, it was not possible to identify precisely which country has the best liquidity ratios in short and long term as more than 60% of the countries did not present sufficient data. In terms of net assets over total assets, and short-term compliance, the Islamic financial systems of Egypt and Afghanistan, respectively, led with better liquidity ratios, showing the ability and security to meet their obligations.
Contributions of the Study: Identify countries with the highest / lowest risk considering IFSB and BCBS requirements and recommendations.
Simple and Fast Determination of Terbinafine in Human Urine by Dilute and Shoot HPLC-DAD Using a Core-Shell Column
Authors: Yıldırım Sercan , Demirdaş Gökhan , Fidan Mert , Yaşar Ahmet 
Published: July 2020

Background:
Terbinafine is an allylamine antifungal that is effective against many
fungi, dermatophytes and moulds. Analytical methods are required for the determination of
terbinafine in biological fluids to perform therapeutic drug monitoring and pharmacokinetic
studies.

Objective:
The aim of this study was to develop and validate a novel and fast method combining
dilute and shoot approach and high-performance liquid chromatography coupled with photodiode
array detection for the determination of terbinafine in human urine.

Methods:
Chromatographic parameters including mobile phase composition, pH, flow rate and
injection volume were assessed and optimized. The separation of terbinafine and naproxen
(internal standard) was achieved within 3 min using a C18 core-shell column (Raptor ARC-18, 100
x 4.6 mm, 2.7 μm) under isocratic conditions. Samples were eluted from the column at the flow
rate of 1.4 mL/min using a mobile phase containing 0.2% triethylamine in water (pH 3.4 with
formic acid): acetonitrile (45:55, v/v).

Results:
The presented technique was linear in the range of 25-2000 ng/mL. Intra- and inter-day
reproducibility at four quality control levels (25, 200, 750 and 1500 ng/mL) were less than 7%,
with relative errors ranging from -5.40% to 5.91%. The limit of detection was 12.60 ng/mL. The
developed method has three main advantages compared to existing methods: simplicity and
greenness of sample preparation, use of core-shell column and short analysis time.

Conclusion:
The results of this study indicate that the combination of dilute and shoot approach
and core-shell column can be regarded as an advantageous application for the fast determination of
terbinafine in the urine.
THE EXPRESSION OF CHILDREN IMAGES IN SELF-BEHAVIOR DEVIATION RESPRESENTATION
Authors: Hidayah Dwi Nur 
Published: July 2020

AbstractThe purpose of this research is to analysisthe work of illustrated imagesin representing deviation of self behaviour’s students in SD 3 Karangbener. The benifit of this study is theoretical benefit that is useful for science so that it can contribute ideas or add information for the development of education.This research method is qualitative with a case study approach chosen as a study participant of 3 students. The Data collection techniques used are in-depth interviews, documentation, observation. Analysis of the validity of the data used in this study is use triangulation and then analyze the data by reducing data, presenting data and verifying. The results obtained are image expressions of thoughts, ideas, and self-concepts regarding the cause of the deviation of expression symbols in the visualization of student images. Keywords: Expression, child image, behavior deviation EKSPRESI GAMBAR ANAK DALAM RESPRESENTASI DEVIASI PERILAKU DIRI (Studi kasus siswa kelas 4 di SD 3 Karangbener Bae Kudus) AbstrakTujuan dari penelitian ini adalah untuk menganalisis hasil karya gambar ilustrasi dalam respresentasikan deviasi perilaku siswa di SD 3 Karangbener. Adapun manfaat penelitian ini adalah manfaat teoritis yaitu berguna untuk ilmu pengetahuan sehingga dapat memberi sumbangan pemikiran atau menambah informasi bagi perkembangan ilmu pendidikan. Metode penelitian ini adalah kualitatif dengan pendekatan studi kasus yang dipilih sebagai partisipan penelitian berjumlah 3 siswa. Teknik pengumpulan data yang digunakan yaitu wawancara mendalam, dokumentasi, observasi. Analisis keabsahan data yang digunakan dalam penelitian ini adalah menggunakan triangulasi kemudian analisis data dengan cara mereduksi data, penyajian data dan verifikasi. Hasil penenlitian yang diperoleh yaitu ekspresi gambar dari pemikiran, ide, dan konsep diri mengenai penyebab deviasi simbol ekspresi dalam visualisasi gambar siswa.Kata kunci: Ekspresi, gambar anak, deviasi perilaku
Facilitating grammar for non-Arabic speakers
Authors: Al-Douri Adnan Abdul-Rahman 
Published: July 2020

اللغة العربية هي لغة القرآن الكريم ولغة رسول الله r ولغة العرب منذ الجاهلية الأولى وإلى يومنا هذا. قال تعالى في كتابه الكريم: )إِنَّا أَنْزَلْناهُ قُرْآناً عَرَبِيًّا لَعَلَّكُمْ تَعْقِلُونَ(([1])
وضابط اللغة العربية هو النحو العربي الذي به تعرف معانيها ومقاصدُها، فهو المعوَّلُ عليه، والمَفْزِعُ إليه.
قال أبو العباس ثعلب (ت 291هـ):
« لا يصح الشعر ولا الغريب ولا القرآن إلاَّ بالنحو, النحو ميزان هذا كلّه.وقال:تعلموا النحو فإنه أعلى المراتب. »([2])
قال أبو بكر الزبيدي (ت 379هـ):
« لم تزل العربُ تنطق على سجيتها في صدر إسلامها وماضي جاهليتها، حتى أظهر اللهُ الإسلامَ على سائر الأديان، فدخل الناسُ فيه أفواجاً، وأقبلوا إليه أرسالاً، واجتمعت فيه الألسنة المتفرقة، واللغات المختلفة، ففشا الفسادُ في اللغة العربية، واستبان منه في الإعراب الذي هو حليُّها، والموضح لمعانيها»([3]).
وفَضلُ القرآنِ الكريم على اللغة العربية كبيرٌ لا يُدرِكُ مَداهُ إِلاَّ من غار في بحره ، وعَرَفَ خفاياه ودُرَرَهُ, وتَذوَّقَ معانيهِ واسرارَهُ. قال ابنُ قَيِّمِ الجَوزِيَّة (ت 751 هـ):
«انما يَعرفُ فضلَ القرآنِ من عرفَ كلامَ العربِ , فعَرفَ علمَ اللغة وعلمَ العربية وعلمَ البيان , ونظر في أشعار العرب وخطبِها ومقالاتِها في مواطنِ افتخارِها ورسائِلها وأراجيزها وأسجاعِها, فعَلِمَ منها تلوينَ الخطابِ ومعدوله , وفنون البلاغة وضروب الفصاحة, وأجناس التجنيس وبدائع البديع، ومحاسن الحكم والأمثال.
The impact of human engineering applications on reducing costs of industrial processes
Authors: Dawood Al-Lami Ghassan Qasim 
Published: July 2020

يسعى البحث الى دراسة وتحليل مدى تطبيق قواعد الهندسة البشرية المتعلقة بالتصميم المناسب لبيئة العمل الداخلية وتاثيراتها بالقدرات الجسدية ومهارات وحاجات العاملين لاداء المهمات المطلوبة بغية المساهمة في تخقيض تكاليف العمليات الصناعية، ولتحقيق هذه الاهداف جمعت البيانات والمعلومات على وفق استمارة الاستبانة اعتمدت خصيصا لهذا الغرض لتحليل نتائجها العملية على عينة متكونة من (118) فردا من العاملين في الشركة العامة للصناعات الجلدية - بغداد.
توصل البحث الى مجموعة استنتاجات أبرزها ضعف الشركة المبحوثة في مراعاة بيئة العمل لتحسين كفاءة عملياتها الصناعية للارتفاع الكبير في تكاليف الانتاج جراء قلة الاهتمام بتطبيق الهندسة البشرية للعاملين في الشركة المبحوثة . وركزت التوصيات على ضرورة الاهتمام والتحسين لترتيب وتنظيم مواقع العمل ،وتصميم الادوات ومكائن واسطح العمل بغية تحسين الكفاءة التشغيلية لاجهزة ومعدات الانتاج وبما تؤدي حتما في انخفاض نكاليف العمليات الصناعية .
The components of the transformation in the human development of Arab countries
Authors: Maher Asaad Hamdi , Jasim Yassin Musa 
Published: July 2020

لم تعد التنمية في الوقت الحاضر مجرد زيادات في معدلات النمو الاقتصادي وما ينعكس ذلك على زيادات في حصة الفرد من الناتج القومي بل أصبحت تتعدى ذلك بكثير حيث تحول الاهتمام بالتنمية إلى جوانب أخرى فإضافة إلى معيار الدخل شملت التنمية مؤشرات التطور الاجتماعي والارتقاء بنوعية الحياة وزيادة الخيارات أمام البشرية إضافة إلى مؤشرات ذات العلاقة الأساسية بالحاجات الإنسانية . ( (Sen.A.1990 فالناس هم الثروة الحقيقية للأمم. وفي الواقع أن هدف التنمية الأساسي هو توسيع حريات الإنسان حيث يمكن لعملية التنمية أن تحرر القدرات البشرية بتوسيع الخيارات المتاحة للناس كي يعيشوا حياة مكتملة وخلاقة وهم في الوقت نفسه المستفيدون من التنمية وعوامل التقدم والتغير التي تحدثها ويجب أن تفيد هذه العملية كل الأفراد وبالتساوي وترسي أسس المشاركة لكل منهم .
The figurative composition in the poetry of Ibn Khafaga
Authors: Al-Ghadhanfari Montaser Abdul Qadir , Alois Saleh 
Published: July 2020

يعمل مصطلح التشكيل في مجالي الشعر والرسم، ذلك لأن ((أجناس الخطاب الثقافي تشترك في رسائل التعبير من أجل تحقيق المبتغى الجمالي)) ([1])، فضلاً عن كون التشكيل يمثل ((عملية إيجاد علاقات مركبة لبناء شكل جديد فإنه لا يختص بحقل أو جنس ثقافي دون سواه، إذ إن بناء الشكل الجديد يشمل الأدب والفنون التشكيلية على السواء)) ([2])، وبذلك لا يعد التشكيل مصطلحاً جديداً مضافاً إلى إلى حقل الشعر ((لأن طريقة الشاعر في تشكيل مادته تشبه طريقة الرسام على أساس أن كليهما يهدف إلى إحداث أكبر قدر ممكن من التناسب والتألق بين عناصر مادته)) ([3])، وبذلك يكون التشكيل في الادب من العمل التصويري، فالتشكيل يعطي الوجود المادي صورته، لذلك تصدق تسمية العمل الفني بالعمل التصويري الذي يكون فيه التشكيل من المادة الصرف إلى المادة الجمالية عند التشكيل وعند كونها صورة، فيكون التشكيل ((هندسة نظام الالفاظ وتناسق نظام الدلالات ومن ثم هندسة الايقاعات الموسيقية، كل ذلك يمثل تشكيلات القصيدة التي تتكون من بنيات بنائية)) ([4]). تؤكد على أن النص الشعري ((كيان تشكيلي قائم بذاته)) ([5]) والتشكيل في النص الشعري لا يكون من تركيب الالفاظ اللغوية ونحتها وجمعها مع بعض وإنما يكون في تالي هذه العملية التي تجعل من مجموعها صوراً ذهنية تجعل لكل نص شعري خصوصية تميزه عن غيره من النصوص، من ((البعد البصري في مفهوم التشكيل)) ([6]).