bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent use of oblique sagittal and oblique coronal MRI: does it enhance the specificity and the accuracy of diagnosing complete and partial ACL tears?
Authors: Soliman Hazem Hamed 
Published: January 2020

AbstractBackgroundThe aim of the study was to evaluate the diagnostic efficacy of utilization of oblique sagittal and oblique coronalMRItechniques separately and concurrently in improving the diagnosis ofanterior cruciate ligament(ACL) complete and partial tears. Between December 2017 and November 2018, 71 patients, with suspected ACL injury, were examined by MRI using four diagnostic approaches: standard routine images only (approach A), standard and oblique coronal images (approach B), standard and oblique sagittal images (approach C), and standard images with both oblique coronal and sagittal images (approach D). Two experienced musculoskeletal radiologists evaluated the MRI images separately and in a random order using the four methods, and findings were compared with arthroscopy results as a gold standard.ResultsThe diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for approach A in diagnosis of partial ACL tear was significantly lower than that for approaches B, C, and D (pvalue < 0.05). The PPV and NPV for approaches B (82% and 85%) and C (83% and 87%) in diagnosis of partial ACL tear which were significantly lower than that for approach D (94% and 95%). The four approaches revealed no significant difference in diagnosis of complete ACL tear (pvalue > 0.05). Approach D demonstrated highest interobserver agreement (94% in complete and 88% in partial ACL tears) in comparison to B (79% in complete and 66% in partial) and C (85% in complete and 71% in partial) when combining oblique sagittal and oblique coronal images in identifying both complete and partial ACL tearsConclusionThe addition of oblique sagittal and coronal images improved diagnostic accuracy of detection of complete and partial ACL tears. The concurrent use of sagittal and coronal oblique images enhanced the diagnostic efficacy of diagnosis of partial ACL tears only.
Structural characterization of potentially seismogenic faults in the Fort Worth Basin
Authors: Horne Elizabeth A. , Hennings Peter H. , Osmond Johnathon L. , DeShon Heather R. 
Published: January 2020

From 2006 through mid-2018, there have been 125 [Formula: see text] recorded earthquakes within the Fort Worth Basin and the Dallas-Fort Worth metropolitan area. There is general scientific consensus that this increase in seismicity has been induced by increases in pore-fluid pressure from wastewater injection and from cross-fault pore-pressure imbalance due to injection and production. Previous fault stress analyses indicate that many of the faults are critically stressed; therefore, careful consideration should be taken when injecting in close proximity to these structures. Understanding the structural characteristics that control geomechanical aspects of these earthquake-prone faults is vital in characterizing this known hazard. To improve understanding of faults in the system, we have developed a characterization using a new basin-wide fault interpretation and database that has been assembled through the integration of published data, 2D and 3D seismic surveys, outcrop mapping, earthquakes, and interpretations provided by operators resulting in a 3D structural framework of basement-rooting faults. Our results show that a primary fault system trends northeast–southwest, creating a system of elongate horsts and grabens. Fault architectures range from isolated faults to linked and cross-cutting relay systems with individual segments ranging in length from 0.5 to 80 km. The faults that have hosted earthquakes are generally less than 10 km long, trend toward the northeast, and exhibit more than 50 m of normal displacement. The intensity of faulting decreases to the west away from the Ouachita structural front. Statistical analysis of the fault length, spacing, throw, and linkage tendency enables a more complete characterization of faults in the basin, which can be used to mitigate the seismic hazard. Finally, we find that a significant percentage of the total population of faults may be susceptible to reactivation and seismicity as those that have slipped recently.
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies
Authors: Kancherla Jayaram , Rao Shruti , Bhuvaneshwar Krithika , Riggins Rebecca B. , Beckman Robert A. , Madhavan Subha , Corrada Bravo Héctor , Boca Simina M. 
Published: January 2020

PURPOSE In this work, we introduce CDGnet (Cancer-Drug-Gene Network), an evidence-based network approach for recommending targeted cancer therapies. CDGnet represents a user-friendly informatics tool that expands the range of targeted therapy options for patients with cancer who undergo molecular profiling by including the biologic context via pathway information. METHODS CDGnet considers biologic pathway information specifically by looking at targets or biomarkers downstream of oncogenes and is personalized for individual patients via user-inputted molecular alterations and cancer type. It integrates a number of different sources of knowledge: patient-specific inputs (molecular alterations and cancer type), US Food and Drug Administration–approved therapies and biomarkers (curated from DailyMed), pathways for specific cancer types (from Kyoto Encyclopedia of Genes and Genomes [KEGG]), gene-drug connections (from DrugBank), and oncogene information (from KEGG). We consider 4 different evidence-based categories for therapy recommendations. Our tool is delivered via an R/Shiny Web application. For the 2 categories that use pathway information, we include an interactive Sankey visualization built on top of d3.js that also provides links to PubChem. RESULTS We present a scenario for a patient who has estrogen receptor (ER)–positive breast cancer with FGFR1 amplification. Although many therapies exist for patients with ER-positive breast cancer, FGFR1 amplifications may confer resistance to such treatments. CDGnet provides therapy recommendations, including PIK3CA, MAPK, and RAF inhibitors, by considering targets or biomarkers downstream of FGFR1. CONCLUSION CDGnet provides results in a number of easily accessible and usable forms, separating targeted cancer therapies into categories in an evidence-based manner that incorporates biologic pathway information.
Standardizing Chemotherapy Regimen Nomenclature: A Proposal and Evaluation of the HemOnc and National Cancer Institute Thesaurus Regimen Content
Authors: Rubinstein Samuel M. , Yang Peter C. , Cowan Andrew J. , Warner Jeremy L. 
Published: January 2020

PURPOSE Due to decades of nonstandardized approaches to the naming of chemotherapy regimens, representation in electronic health records and secondary systems is highly variable. This hampers efforts to understand patterns of chemotherapy usage at the population level. In this article, we describe a proposal for rules to standardize the nomenclature of chemotherapy regimens and illustrate applications of these rules. METHODS Through our experience with building HemOnc.org, which has been under construction since 2011, we formulated a set of guidelines and recommendations for the standard representation of chemotherapy regimen names. We then performed a mapping between the HemOnc and National Cancer Institute Thesaurus vocabulary’s regimens and evaluated conformance with the naming conventions. Finally, we assembled a database of acronyms and names for multiple myeloma regimens to illustrate the scope of the problem. RESULTS For the first use case, 242 of 527 (45.1%) of the regimen names differed. The schema was able to allocate a preferred source for 217 (89.4%) of these regimens. For the second use case, we expanded 130 multiple myeloma regimens to 1,138 unique regimen names and demonstrate ways in which the schema can collapse these into disambiguated, but abbreviated, regimen names. CONCLUSION To our knowledge, this is the first proposal to normalize chemotherapy regimen nomenclature. If our recommendations are adopted, we expect that the uniformity of treatment exposure representation in hematology/oncology will increase, which will enable large-scale efforts such as ASCO’s CancerLinQ to achieve better standardization.
Time-Maps
Authors: Cooppan Vilashini 
Published: January 2020

Abstract
This article considers how time, space, and history are mobilized across a contemporary range of debates in postcolonial studies, world literature theory, and memory studies. The time-maps surveyed all revolve around Eurochronology and its contestations, and range from novels by Joseph Conrad and V.S. Naipaul, to a video installation and essay by the South African artist William Kentridge, to the critical study of the Indian Ocean world. Traversing literature, art, critical theory, and personal story, the essay provides an imaginative and imagistic guide to new ways of thinking time. It concludes with a speculation on the promise of a “soft” rather than “mean” time, the latter evoking imperial standardization and the former describing a terrain in which affect and history are set in rippling motion.
Prognostic Significance and Functional Relevance of Olfactomedin 4 in Early-Stage Hepatocellular Carcinoma
Authors: Ye Liangtao , Kriegl Lydia , Reiter Florian P. , Munker Stefan M. , Itzel Timo , Teufel Andreas , Ziesch Andreas , Török Helga Paula , Kirchner Thomas , Gerbes Alexander L. , Guba Markus , Mayerle Julia , De Toni Enrico N. 
Published: January 2020

OBJECTIVES:
Hepatocellular carcinoma (HCC) is a leading cancer-related cause of death. Unfortunately, recurrence is common even after curative treatment of early-stage patients, and no adjuvant treatment has yet been established. Aberrant expression of OLFM4 in human cancers has been reported; yet, its specific function during tumor development remains poorly understood, and its role in HCC is unknown. The purpose of this study is to examine the prognostic significance of OLFM4 and its functional relevance in determining recurrence in patients with early-stage HCC.

METHODS:
Immunohistochemical staining to assess expression, cellular distribution, and prognostic significance of OLFM4 was performed in a tissue microarray comprising 157 HCC tissues and matched nontumor tissues. In addition, expression of OLFM4-coding mRNA was assessed in a separate patients' cohort. The findings were validated by in vitro functional studies using siRNA directed against OLFM4 to assess its effect on cell motility and proliferation.

RESULTS:
The fraction of HCC samples exhibiting positive OLFM4 staining was higher in comparison with that observed in hepatocytes from matched nontumor tissue (61% vs 39%). However, cytoplasmic-only staining for OLFM4 was associated with vascular invasion (P = 0.048), MMP-7 expression (P = 0.002), and poorer survival (P = 0.008). A multivariate analysis confirmed the independent significance of OLFM4 in determining patients' outcome (5-year survival [58.3% vs 17.3%; HR: 2.135 {95% confidence interval: 1.135–4.015}; P = 0.019]). Correspondingly, inhibition of OLFM4 by siRNA modulated the expression of MMP-7 and E-cadherin, causing inhibition of cell proliferation, motility, and migration.

DISCUSSION:
To the best of our knowledge, we provide the first report on the prognostic significance of OLFM4 in HCC and identify its mechanistic role as crucial mediator of MMP family protein and E-Cadherin in determining cell invasion and metastasis formation.
MORPHOLOGICAL MARKERS OF THE POST EXERCISE STRUCTURAL AND FUNCTIONAL DISORDERS OF THE LOCOMOTOR APPARATUS
Authors: Nikolenko V , Oganesyan M , Vovkogon A , Sankova M , Rizaeva N 
Published: January 2020

Aim. The article deals with establishing the character of the correlations between the somatometrical features and morphological signs of connective tissue dysplasia in persons with frequent post exercise structural and functional disorders of the locomotor apparatus. This is required for creating treatment and disease preventive measures and recommendations to choose an adequate physical activity. Materials and methods. A comprehensive medical and anthropological examination of 48 people aged from 18 to 47 years (mean age 36.38 ± 6.02 years) with frequent post exercise structural and functional disorders of the locomotor apparatus was carried out. A questionnaire was developed to assess the status of their connective tissue. The control group consisted of 36 apparently healthy people aged 18.85 ± 0.56 years. Statistical processing of the data obtained was performed using Microsoft Excel 2010. Results. All patients with frequent post exercise structural and functional disorders of the locomotor apparatus had connective tissue dysplasia of moderate and severe degree, the total score of which was 49.44 ± 13.1. The analysis of the frequency of connective tissue dysplasia morphological signs occurrence depending on their diagnostic significance, made it possible to establish the pathognomonic predictors of high susceptibility to frequent disorders of the locomotor apparatus. Conclusion. Early diagnostics of frequent disorders of the locomotor apparatus will contribute to timely preventive measures in terms of physical load and a corresponding rehabilitation for eliminating the deve­lopment of the main disorder.
Perbandingan Taman Jepang Dan Taman Jawa
Authors: Mulyadi Budi 
Published: January 2020

(Title: Comparison Of Japanese Garden And Java Garden). The purpose of this paper is to find out the similarities and differences between Japanese garden and Java garden This research is research model that use literary review research model to collect the data. The paper shows that there are the similarities and differences between Japanese garden and Java garden. Seen from the concept Japanese Gardens do not recognize straight or symmetrical lines. Japanese gardens are deliberately designed asymmetric so that none of the elements become dominant while the Java garden concept is more concerned with beauty by planting many types of flowers that contain elements of philosophy seen from its elements, Japanese garden has 7 elements, namely water, stone, plants, water containers, bridges, sand and lanterns while the Java park has water elements, plants, buildings and organisms
KAJIAN PENGGUNAAN LAHAN DI SEKITAR KAWASAN BUKIT SEMARANG BARU
Authors: Oktinova Nadia , Rudiarto Iwan 
Published: January 2020

Jumlah penduduk di pusat kota yang cukup besar mengakibatkan semakin berkurangnya lahan di wilayah tersebut sehingga lambat laun akan terjadi perkembangan perkotaan ke arah pinggiran (urbanisasi), seperti yang terjadi di Kota Semarang yaitu pengembangan kota baru Bukit Semarang Baru (BSB) di Kecamatan Mijen. Dengan adanya BSB ini terjadi perubahan penggunaan lahan yang kemudian juga mengakibatkan adanya perkembangan perkotaan di sekitarnya. Dengan adanya hal tersebut, penelitian ini bertujuan untuk menganalisis perubahan penggunaan lahan dan perkembangan perkotaan yang terjadi di sekitar kawasan BSB. Pendekatan penelitian ini yaitu pendekatan kuantitatif dengan pendekatan spasial yang pengolahan data serta analisisnya secara spasial menggunakan software ArcGIS 10.3.1. Data penggunaan lahan diperoleh dengan interpretasi citra DigitalGlobe tahun 2013 dan tahun 2017 yang kemudian dilakukan teknik overlay untuk mengetahui perubahan penggunaan lahannya. Hasil dari penelitian ini yaitu telah terjadi perubahan penggunaan lahan dari lahan pertanian menjadi danau/waduk (36,45 ha), industri (14,98 ha), lahan kosong (22,41 ha), perdagangan dan jasa (2,78 ha) dan permukiman (84,84 ha) serta perubahan penggunaan lahan permukiman menjadi perdagangan dan jasa (2,59 ha). Di sekitar kawasan BSB juga telah terjadi perkembangan perkotaan yang terlihat dari peningkatan penggunaan lahan terbangun sebesar 102,59 ha dengan pola konsentris dan horisontal dimana lahan terbangunnya ini menyebar pada seluruh wilayahnya.
Clinicians’ and laboratory medicine specialists’ views on laboratory demand management: a survey in nine European countries
Authors: Ibarz Mercedes , Cadamuro Janne , Sumarac Zorica , Guimaraes Joao Tiago , Kovalevskaya Svetlana , Nybo Mads , Cornes Michael P. , Vermeersch Pieter , Simundic Ana-Maria , Lippi Giuseppe 
Published: January 2020

Abstract

Background
Laboratory tests are an essential aspect of current medical practice and their use has grown exponentially. Several studies however have demonstrated inappropriate use of laboratory testing. This inappropriateness can lead to delayed or wrong diagnosis, negatively impacting patient safety and an increase in health care expenditure. The aim of the present small-scale survey was to obtain information on the current status of demand management in European laboratories, as well as the opinions of laboratory and clinical professionals in this regard.

Methods
Two surveys were developed, one for laboratory specialists and one for clinicians, covering information on current use, knowledge and opinions on the possible impact of different demand management strategies on patient outcome and health care costs. Additionally, we asked for the current state and willingness on collaboration of laboratory specialists and clinicians.

Results
One hundred and fifty responses, 72 laboratory specialists and 78 clinicians, from nine countries were received. Developing local ordering protocols/profiles in collaboration with clinicians was the most used strategy (80.3% of laboratories). Of clinicians, 85.6% considered measures to ensure appropriate use of tests necessary and 100% were interested in advice/information about their indication. Of the laboratory specialists 97.2% were either already participating or willing to participate in multidisciplinary groups on the appropriateness of test demand as were 60.3% of clinicians, and 85.9% of clinicians were interested in attending activities about laboratory test demand management.

Conclusions
The results of our survey show that tools to improve the appropriate use of laboratory tests are already regularly used today. Laboratory medicine specialists as well as clinicians are willing to undertake additional shared activities aimed at improving patient-centered laboratory diagnostic workup.
Beech wood treated with polyglycerol succinate: a new effective method for its protection and stabilization
Authors: L’Hostis Clément , Fredon Emmanuel , Thévenon Marie-France , Santiago-Medina Francisco-José , Gérardin Philippe 
Published: January 2020

Abstract
This paper deals with an original and non-biocidal chemical treatment consisting of a vacuum/pressure impregnation step of beech wood with a water-borne mixture made from heat-activated condensation of succinic anhydride (SA) and glycerol (G). Chemical structures of adducts were established using matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF) investigations. Beech wood was impregnated and cured in order to induce in situ polymerization of glycerol/succinic adducts (GSA) in the cell walls, leading to the formation of polyglycerol succinate (PGS) polyester. Various treatment conditions were investigated depending on the duration (6–72 h) and curing temperature (103–160°C). Weight percent gains (WPGs) ranging between 40 and 60% were obtained. Attenuated total reflectance-middle infrared spectroscopy (ATR-MIR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy confirmed polyester formation. A curing temperature of 160°C was found to be the best condition to totally avoid polymer leaching, and brought the anti-swelling efficiency (ASE) up to 64%. Decay resistance of PGS-treated wood against Trametes versicolor and Coniophora puteana was also strongly temperature and time dependent: performances fit with the EN113 standard requirements if a curing temperature of 160°C was applied.
Exploring vowel formant estimation through simulation-based techniques
Authors: Kendall Tyler , Vaughn Charlotte 
Published: January 2020

AbstractThis paper contributes insight into the sources of variability in vowel formant estimation, a major analytic activity in sociophonetics, by reviewing the outcomes of two simulations that manipulated the settings used for linear predictive coding (LPC)-based vowel formant estimation. Simulation 1 explores the range of frequency differences obtained when minor adjustments are made to LPC settings, and measurement timepoints around the settings used by trained analysts, in order to determine the range of variability that should be expected in sociophonetic vowel studies. Simulation 2 examines the variability that emerges when LPC settings are varied combinatorially around constant default settings, rather than settings set by trained analysts. The impacts of different LPC settings are discussed as a way of demonstrating the inherent properties of LPC-based formant estimation. This work suggests that differences more fine-grained than about 10 Hz in F1 and 15–20 Hz in F2 are within the range of LPC-based formant estimation variability.
Template-free synthesis of Se-nanorods-rGO nanocomposite for application in supercapacitors
Authors: Ghouri Zafar Khan , Motlak Moaaed , Afaq Shagufta , Barakat Nasser A. M. , Abdala Ahmed 
Published: January 2020

AbstractBoth selenium and reduced graphene oxide have low specific capacitance due to their chemical nature. Nevertheless, their specific capacitance could be enhanced by hybridizing Se nanomaterials with reduced graphene oxide via formation of electrochemical double layer at their interfacial area. Therefore, novel Se-nanorods/rGO nanocomposite was successfully synthesized by template free hot reflux route starting with graphene oxide and selenium dichloride. The composite of rGO decorated by Se-nanorods is characterized using X-ray diffractometry (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and nitrogen adsorption– desorption. The unique architecture of the composite exhibits high specific capacitance of 390 F/ g at 5 mV/s scan rate in 1.0 M KOH solution with ~ 90% cyclic stability after 5000 cycles making it very promising electrode material for supercapacitor applications.
Cotton fibres functionalized with plasmonic nanoparticles to promote the destruction of harmful molecules: an overview
Authors: Boufi Sami , Bouattour Soraa , Ferraria Ana Maria , Ferreira Luís Filipe Vieira , Rego Ana Maria Botelho do , Chehimi Mohamed M. , Vilar Manuel Rei 
Published: January 2020

AbstractSelf-decontaminating cotton fabrics were designed, produced and characterized aiming at the decomposition of harmful molecules namely chemical warfare agents (CWAs) by photocatalysis under day light or indoor illumination. This was achieved through the creation of a hybrid organic-inorganic nanostructured textile composed of a thin layer of TiO2nanoparticles (NPs) generatedin situand chemically immobilised on the cellulose chains of cotton fibres. TiO2NPs were converted into anatase by a hydrothermal procedure at low temperature around 100°C. The fabrics covered with TiO2nanoparticles were examined in terms of their chemical composition, morphology, crystallinity, ageing, robustness and photocatalytic properties. In the whole preparation of the photocatalytic fabrics, only environment-friendly solvents (water or alcohol) were used. One of the important achievements in this work was providing fabrics with suitable photocatalytic activity under visible light. This was reached through plasmonic photocatalysis by generating noble metal nanoparticles (Au, Ag) and/ or their halides (AgBr, AgCl) neighbouring or topping the TiO2NPs in the fabrics. The kinetics of degradation of the different systems were analysed and proved that the resulting fabrics could efficiently decompose, under visible light, organic dyes and dimethyl methylphosphonate (DMMP), a CWA simulant.Graphical abstract