bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shigella sonnei Outbreak Investigation During a Municipal Water Crisis—Genesee and Saginaw Counties, Michigan, 2016
Authors: McClung R. Paul , Karwowski Mateusz , Castillo Caroline , McFadden Jevon , Collier Sarah , Collins Jim , Soehnlen Marty , Dietrich Stephen , Trees Eija , Wilt Grete , Harrington Christina , Miller Ashley , Adam Elizabeth , Reses Hannah , Cope Jennifer , Fullerton Katie , Hill Vincent , Yoder Jonathan 
Published: April 2020

Objectives. To investigate a shigellosis outbreak in Genesee County, Michigan (including the City of Flint), and Saginaw County, Michigan, in 2016 and address community concerns about the role of the Flint water system. Methods. We met frequently with community members to understand concerns and develop the investigation. We surveyed households affected by the outbreak, analyzed Shigella isolate data, examined the geospatial distribution of cases, and reviewed available water quality data. Results. We surveyed 83 households containing 158 cases; median age was 10 years. Index case-patients from 55 of 83 households (66%) reported contact with a person outside their household who wore diapers or who had diarrhea in the week before becoming ill; results were similar regardless of household drinking water source. Genomic diversity was not consistent with a point source. In Flint, no space-time clustering was identified, and average free chlorine residual values remained above recommended levels throughout the outbreak period. Conclusions. The outbreak was most likely caused by person-to-person contact and not by the Flint water system. Consistent community engagement was essential to the design and implementation of the investigation.
The Use of Small Area Estimates in Place-Based Health Research
Authors: Kong Amanda Y. , Zhang Xingyou 
Published: April 2020

Interest in the impact of the built environment on health behaviors, outcomes, and disparities is increasing, and the growing development of statistical modeling techniques has allowed researchers to better investigate these relationships. However, without enough data that are identifiable at smaller geographic levels (e.g., census tract), place-based health researchers are unable to reliably estimate the prevalence of a health outcome at these more granular and potentially more salient neighborhood levels. When reliable direct survey estimates cannot be produced because of small samples or a lack of samples, estimates based on small area estimation techniques are often used. As place-based health research and the production and secondary use of small area estimates increase, it is critical that researchers understand both the underlying methods used to create these estimates and their limitations. Without this foundation, researchers may fit inappropriate models, or interpret findings inaccurately. As a demonstrative example, we focus this discussion on the small area health indicator estimates recently produced through the 500 Cities Project by the Robert Wood Johnson Foundation, the Centers for Disease Control and Prevention (CDC), and the CDC Foundation.
Complete Intrasubstance Rupture of the Biceps Brachii Via Atypical Eccentric Contraction
Authors: Parisien Robert L. , Dashe Jesse , Alley Maxwell C. , Stein Andrew 
Published: April 2020

Case:
A 46-year-old man presented with extensive swelling and ecchymosis of the arm and antecubital fossa after a 4-foot fall from a ladder in which he attempted to arrest his decent by grabbing onto a wooden ceiling beam. Ultrasound and magnetic resonance imaging confirmed a complete intrasubstance rupture of the biceps brachii. Nonoperative management was recommended and, at 9-week follow-up, the patient had resumed light weightlifting and demonstrated painless full active range of motion.

Conclusions:
Uncommon complete intrasubstance biceps brachii ruptures can occur via an atypical mechanism of isotonic eccentric muscle contraction and satisfactory results may be realized through nonoperative management.
Formula of Yellow Kepok Banana (Musa acuminata x Musa balbisiana) Corm Extracts As Antiinflamation
Authors: Wenas Desy Muliana , Aliya Lisana Sidqi , Anjani Wisma Merry 
Published: April 2020

<p><em><em>Bananas have many types and benefits. One of them is the Yellow Kepok Banana. Banana stem, leaf midrib, and corm contain phytochemicals compound as medicinal properties. The study aimed to determine the effect of the yellow kepok banana corm extract formula as an anti-inflammatory. Banana corm was cut into 0.3 x 1 x 3 cm pieces, dried in the oven with temperature 60 °C for 6 hours, then made 40 mesh powder. The powder extracted using 70 % ethanol by maceration technique for 24 hours, repeated three times. Anti-inflammatory testing was carried out on male </em>Sprague Dawley<em> white rats. A total of 24 white rats were divided into six treatment groups, consists of </em><em>different concentrations of the extract (10, 15, and 20 %), positive control (commercial ointment), negative control, and a normal control (giving a wound without being given any formula). The experiment was designed as a randomized complete, with four replications, data were analyzed using ANOVA and the </em>Post Hoc Games Howell Test<em>. The results showed that the yellow kepok banana extract formula had the potential for wound healing. The 20 % extract formula can accelerate wound healing in a day than the 10 and 15 % formulas. The speed is shown by wound healing without scars from the 20 %</em> <em>extract formula, which occurs earlier than other formulas. The anti-inflammatory activity of the 20 % formula was comparable to the positive control of commercial ointment. The anti-inflammatory activity of the yellow kepok banana ointment formula is related to the compound of saponins, flavonoids, and tannins. The results indicate that the yellow kepok banana corm extract has the potential to be developed as an anti-inflammatory drug.</em><br /></em></p>
STRATEGI PENGEMBANGAN RANTAI PASOK KENTANG BERKELANJUTAN DI KABUPATEN MAGETAN
Authors: Hidayati Arum , Irianto Heru , Kusnandar NFN 
Published: April 2020

<strong>English</strong><br />The accelerating demand growth as reflected by significant increase of potato consumption per capita indicates high potential of potato development in Indonesia. Potato production in Magetan Regency in recent years, however, has been fluctuating, perhaps due to some weaknesses in its supply chains. The objective of this study, therefore, is to formulate a sustainable supply chain development strategy for potato in Magetan Regency. The study was conducted using the Sustainable Supply Chain Management perspective and the Analytical Network Process. The study was conducted in 2016. The results show that development of sustainable supply chain is the key for accelerating and stabilization of potato production growth. Although the economic dimension is the highest priority, the social and environmental dimensions are almost equally important as well. While varietal and technological choice should be based on the highest profit, it nevertheless should also be socially acceptable and environmentally friendly, such as the Granola variety in Magetan Regency. The priority actors are farmers, government, and traders (collectors and wholesalers). The priority strategic action programs are increasing potato farming product quality and productivity, increasing potato value added, and empowering of farmers and farmers’ groups.<br />Keywords: <br /><br /><strong>Indonesian</strong><br />Akselerasi pertumbuhan permintaan yang dicerminkan oleh peningkatan nyata konsumsi per kapita mengindikasikan bahwa kentang berpotensi besar untuk dikembangkan di Indonesia. Namun demikian, produksi kentang di Kabupaten Magetan dalam beberapa tahun terakhir ternyata berfluktuasi yang ditengarai akibat dari beberapa kelamahan pada rantai pasok. Sejalan dengan itu, penelitian ini bertujuan untuk merumuskan strategi pengembangan kinerja rantai pasok berkelanjutan untuk kentang di Kabupaten Magetan. Penelitian dilakukan dengan perspektif Sustainable Supply Chain Management dan metode analisis the Analytical Network Process. Penelitian dilakukan pada 2016. Penelitian menunjukkan bahwa pengembangan rantai pasok berkelanjutan adalah kunci untuk akselerasi dan stabilisasi produksi. Dimensi ekonomi merupakan prioritas utama, namun dimensi sosial dan lingkungan hampir sama pentingnya. Pemilihan varietas atau teknologi didasarkan pada keuntungan terbesar, namun juga diterima secara sosial dan ramah lingkungan, seperti varietas Granola di Kabupaten Magetan. Aktor terpenting ialah petani, pemerintah, dan pedagang (pengumpul dan pedagang besar). Program aksi strategis diprioritaskan pada peningkatan kualitas dan produktivitas usaha tani, peningkatan nilai tambah kentang, serta pemberdayaan petani dan kelompok tani.
Management of initial colonisations with Burkholderia species in France, a retrospective analysis in five Cystic Fibrosis Centres
Authors: Gruzelle Vianney , Guet-Revillet Hélène , Segonds Christine , Bui Stéphanie , Macey Julie , Chiron Raphael , Michelet Marine , Murris-Espin Marlène , Mittaine Marie 
Published: April 2020

Abstract
Whereas Burkholderia infections are recognized to impair prognosis in cystic fibrosis (CF) patients, there is no recommendation to date for early eradication therapy. The aim of our study was to analyse the current management of initial colonisations with Burkholderia cepacia complex (BCC) or B. gladioli in French CF Centres and its impact on bacterial clearance and clinical outcome. We performed a retrospective review of the primary colonisations (PC) observed between 2010 and 2018 in five CF Centres. Treatment regimens, microbiological and clinical data were collected. Seventeen patients (14 with BCC, and 3 with B. gladioli) were included. Eradication therapy, using heterogeneous combinations of intravenous, oral or nebulised antibiotics, was attempted in 11 patients. Six out of the 11 treated patients, and 4 out of the 6 untreated patients cleared the bacterium. Though not statistically significant, higher FEV1 and FVC at PC and consistency of treatment with in vitro antibiotic susceptibility tended to be associated with eradication. Thus, the management of PC was shown to be heterogeneous, and the statistic power of our study insufficient. Large prospective studies are needed to define who to treat, when, and how. Pending these studies, we propose, due to possible spontaneous clearance, to check the presence of Burkholderia one month after PC before starting antibiotics, at least in the milder cases, and to evaluate a combination of IV beta-lactam + oral or IV fluoroquinolone + inhaled aminoglycoside.
Contrast-enhanced transrectal ultrasound can reduce collection of unnecessary biopsies when diagnosing prostate cancer and is predictive of biochemical recurrence following a radical prostatectomy in patients with localized prostate cancer
Authors: Zhao Hong-wei , Li Jian , Cao Jia-Zheng , Lin Juan , Wang Zhu , Lv Jian-yao , Wei Jin-huan , Chen Zhen-hua , Yao Hao-hua , Pan Yi-hui , Gao Zhen-li , Luo Jun-hang , Chen Wei , Shi Lei , Fang Yong 
Published: April 2020

Abstract
Background: To investigate the value of using contrast-enhanced transrectal ultrasound (CETRUS) to reduce unnecessary collection of biopsies during prostate cancer diagnosis and its utility in predicting biochemical recurrence in patients with localized prostate cancer. Methods: This was a prospective study of suspected prostate cancer patients who were evaluated with CETRUS followed by a prostate biopsy. Prostate blood flow via CETRUS was graded using a 5-point scale. The relationship between CETRUS score and biopsy outcome was then analyzed for all patients; univariate and multi-variate analyses were used to determine the probable prognostic factors for biochemical recurrence in patients with localized prostate cancer that underwent a radical prostatectomy. Results: A total of 347 patients were enrolled in the study. Prostate cancer was found in 164 patients. A significant positive correlation (r = 0.69, p < 0.001) was found between CETRUS scores and prostate cancer incidence. Using CETRUS scores ≥ 2 as the threshold for when to biopsy could have safely reduced the number of biopsies taken overall by 12.1% (42/347) and spared 23.0% (42/183) of patients from undergoing an unnecessary biopsy. 77 patients with localized prostate cancer underwent a radical prostatectomy. The median follow-up time was 30 months (range: 8-56 months) and 17 of these 77 patients exhibited biochemical recurrence during the follow-up period. 3-year biochemical recurrence-free survival rates were 86% for patients with low CETRUS scores (≤ 3) and 59% for patients with high scores (> 3; p = 0.015). Multivariate Cox regression analysis indicated that CETRUS score was an independent predictor of biochemical recurrence (HR: 7.02; 95% CI: 2.00-24.69; p = 0.002). Conclusions: CETRUS scores may be a useful tool for reducing the collection unnecessary biopsy samples during prostate cancer diagnosis and are predictive of biochemical recurrence in patients with localized prostate cancer following a radical prostatectomy.
Potential contributions of an on-site nurse mentoring program on neonatal mortality reductions in rural Karnataka state, South India: evidence from repeat community cross-sectional surveys
Authors: Ramesh B.M. , Kar Arin , Jayanna Krishnamurthy , Hallad Jyoti S. , Troy Cunningham , Potty Rajaram , Mohan H L , Crockett Maryanne , Bradley Janet , Fischer Elizabeth , Sudarshan H , Blanchard James , Moses Stephen , Avery Lisa 
Published: April 2020

Abstract

Background: We assessed the effects of a nurse mentoring program on neonatal mortality in eight districts in India.Methods: From 2012 to 2015, nurse mentors supported improvements in critical MNCH-related practices among health providers at primary health centres (PHCs) in northern Karnataka, South India. Baseline (n=5,240) and endline (n=5,154) surveys of randomly selected ever-married women were conducted. Neonatal mortality rates (NMR) among the last live-born children in the three years prior to each survey delivered in NM and non-NM-supported facilities were calculated and compared using survival analysis and cumulative hazard function. Mortality rates on days 1, 2-7 and 8-28 post-partum were compared. Cox survival regression analysis measured the adjusted effect on neonatal mortality of delivering in a nurse mentor supported facility. Results: Overall, neonatal mortality rate in the three years preceding the baseline and endline surveys was 30.5 (95% CI 24.3-38.4) and 21.6 (95% CI 16.3-28.7) respectively. There was a substantial decline in neonatal mortality between the survey rounds among children delivered in PHCs supported by NM: 29.4 (95% CI 18.1-47.5) vs. 9.3 (95% CI 3.9-22.3) (p=0.09). No significant declines in neonatal mortality rate were observed among children delivered in other facilities or at home. In regression analysis, among children born in nurse mentor supported facilities, the estimated hazard ratio at endline was significantly lower compared with baseline (HR: 0.23, 95% CI: 0.06-0.82, p=0.02).Conclusion: The nurse mentoring program was associated with a substantial reduction in neonatal mortality. Further research is warranted to delineate whether this may be an effective strategy for reducing NMR in resource-poor settings.
Nausea, vomiting and poor appetite during pregnancy and adverse birth outcomes in rural Nepal: an observational cohort study
Authors: Wallin Amanda Regodón , Tielsch James M , Khatry Subarna K , Mullany Luke C , Englund Janet A , Chu Helen , LeClerq Steven C , Katz Joanne 
Published: April 2020

Abstract
Background Nausea and vomiting are experienced by a majority of pregnant women worldwide. Previous studies have yielded conflicting results regarding their impact on birth outcomes and few studies have examined this relationship in settings with limited resources. We aimed to determine the effect of nausea, vomiting and poor appetite during pregnancy on birth outcomes in rural Nepal.Methods Observational cohort study using data collected in two randomized, community-based trials to assess the effect of influenza immunization during pregnancy on reproductive and respiratory outcomes among pregnant women and their offspring. Pregnant women in Sarlahi District, Nepal were recruited from 2011-2013. Exposure was defined as nausea, vomiting or poor appetite at any point during pregnancy and by trimester; symptoms were recorded monthly throughout pregnancy. Adverse outcomes were low birth weight (LBW), preterm birth and small for gestational age (SGA). Adjusted relative risks (aRR) with 95% CIs is reported from Poisson regressions with robust variance.Results Among 3,623 pregnant women, the cumulative incidence of nausea, vomiting or poor appetite was 49.5% (n=1793) throughout pregnancy and 60.6% (n=731) in the first trimester. Significantly higher aRRs of LBW and SGA were observed among women experiencing symptoms during pregnancy as compared to symptom free women (LBW: aRR 1.20; 95% CI 1.05 1.28; SGA: aRR 1.16; 95% CI 1.05 1.28). Symptoms in the first trimester were not significantly associated with any of the outcomes. In the second trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.17; 95% CI 1.01 1.36; SGA: aRR 1.16; 95% CI 1.05 1.29) and a significantly lower aRR for preterm birth (aRR 0.75; 95% CI 0.59 0.96). In the third trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.20; 95% CI 1.01 1.43; SGA: aRR 1.14; 95% CI 1.01 1.29).Conclusions Symptoms of nausea, vomiting or poor appetite during pregnancy are associated with LBW, SGA and preterm birth in a setting with limited resources, especially beyond the first trimester.Trial registration ClinicalTrials.gov number (NCT01034254)
Community and health staff perceptions on non-communicable disease management in El Salvador’s Health System: a qualitative study
Authors: Vidal Nicole , León-García Montserrat , Jiménez Marta , Bermúdez Keven , De Vos Pol 
Published: April 2020

Abstract

Background: Non-communicable Diseases (NCDs) are the leading cause of global mortality and disability, with a rising burdenin low- and middle-income countries. Their multifactorial aetiology, and their requirement of long-term care, imply the need for comprehensive approaches. From 2009, the Ministry of Health (MoH) in El Salvador has developed a national public health system based on comprehensive primary health care. This study aims to describe the different stakeholders’ perceptions about the management of NCDs along the pathways of care in this health system. Methods : During three fieldwork periods in 2018, three complementary qualitative data collection methods were deployed and conducted in settings with high prevalence of NCDs within El Salvador. First, illness narrative methodology was used to document the life histories of people living with a chronic disease and being treated in second and third level health facilities. Second, through social mapping, support resources that NCD patients used throughout the process of their illness within the same settings were analysed. Third, semi-structured interviews were conducted in the same locations, with both chronic patients and health personnel working at different levels of the primary health care setting. Participants were recruited through purposive and snowball sampling, and a deductive approach was implemented for coding during the analysis phase. After grouping codes into potential themes, a thematic framework was developed using a reflexive approach and following triangulation of the data. Results : This innovative approach of combining three well-defined qualitative methods identified key implications for the implementation of a comprehensive approach to NCD management in resource-poor settings. The following elements are identified: 1) social risk factors and barriers to care; 2) patient pathways to NCD care; 3) available resources identified through social connections mapping; 4) trust in social connections; and 5) community health promotion and NCD prevention management. Conclusions: Salvadoran public health system has been able to strengthen its comprehensive approach to NCDs, combining a clinical approach – including long term follow-up – with a preventive community-based strategy. The structural collaboration between the health system and the (self-) organised community has been key to identify failings, discuss tensions and work out adapted solutions.
Indigenous uses of wild and tended plant biodiversity maintain ecosystem services in agricultural landscapes of the Terai Plains of Nepal
Authors: Thorn Jessica P. R. , Thornton Thomas F. , Helfgott Ariella , Willis Katherine J. 
Published: April 2020

Abstract
Background Despite a rapidly accumulating evidence base quantifying ecosystem services, the role of biodiversity in the maintenance of ecosystem services in shared human-nature environments is still understudied, as is how indigenous and agriculturally dependent communities perceive, use and manage biodiversity. The present study aims to document traditional ethnobotanical knowledge of the ecosystem service benefits derived from wild and tended plants in rice-cultivated agroecosystems, compare this to botanical surveys, and analyse the extent to which ecosystem services contribute social-ecological resilience in the Terai Plains of Nepal.Method Sampling was carried out in four landscapes, 22 Village District Committees and 40 wards in the monsoon season. Data collection was based on transects walks to collect plant specimens, structured and semi-structured interviews, and participatory fieldwork in and around home gardens, farms, and production landscapes. We asked 180 farmers to free-list vernacular names and describe use-value of wild and tended plants in rice-cultivated agroecosystems. Uses were categorized into eight broad groupings, and 61 biomedical ailment classifications. We assessed if knowledge of plant species diversity and abundance differed with regard to caste, age and gender. Results Nepalese farmers have a deep knowledge of the use and management of the 391 vascular plant specimens identified, which provide key provisioning, regulating, supporting and cultural ecosystem services. Altogether, plants belong to 76 distinct plant species from 49 phylogenetic families: 56 are used to cure 61 ailments, 27 for rituals, 25 for food, 20 for timber, 17 for fuel, 17 for fodder, 11 for soil enhancement, and 8 for pesticides. Four caste groups have statistically different knowledge, and younger informants report a lower average number of useful plants. Conclusion Agricultural landscapes in Nepal are reservoirs of biodiversity. The knowledge of the use of wild and tended plant species in and around these farms differs by the caste and age group of land manager. Conducting research on agroecosystems will contribute to a deeper understanding of how nature is perceived by locals, to more efficient management and conservation of the breadbasket of Nepal, and to the conservation of valuable, but disappearing traditional knowledge and practice.