bluuebunny/crossref_metadata_2025_split huggingface dataset:
For love or money: investigating the love of money, Machiavellianism and accounting students’ ethical perception
Authors: Maggalatta Alif , Adhariani Desi 
Published: May 2020

PurposeThe purpose of this study is to explain the effect of love of money and Machiavellianism on ethics perceptions of accounting students. The knowledge attained from this study will allow lecturers and academicians to improve the methods used for teaching ethics in accounting by evaluating the impact of two factors.Design/methodology/approachThis research uses survey and quantitative analysis. The data were collected by distributing offline and online questionnaires to students in a university in Indonesia.FindingsThe results show that both the love of money and Machiavellianism negatively affect ethical perception. Gender as one of the control variables is found to have a significant association with the love of money, Machiavellianism and ethical perception of accounting students.Research limitations/implicationsThe practical implication of the research is the need to inform students on the negative impact of the love of money and Machiavellianism on ethics, as well as the required steps to overcome such negative impact by inserting ethics-related materials in several accounting courses.Originality/valueAccounting students represent future accountants and highly ethical accountants will protect the profession and society from harmful consequences of unethical accounting and business practices.
Drivers of Ar-Rahnu (pawn) acceptance: Malaysian evidence
Authors: Mohd Thas Thaker Hassanudin , Khaliq Ahmad , Mohd Thas Thaker Mohamed Asmy Bin , Allah Pitchay Anwar Bin , Sakaran K. Chandra 
Published: May 2020

PurposeThe purpose of this paper is to examine the factor persuading the acceptance of Islamic pawn broking (Ar-Rahnu) among Islamic bank customers.Design/methodology/approachThe authors collected the data using a self-administered questionnaire design and analysed using SPSS Statistics and smart partial least square. The study is restricted to only respondents who are based in the area of Klang Valley (Selangor and Kuala Lumpur), as these two areas have a larger number of Islamic banks and a decent number of Islamic banks’ clients. A total of 381 respondents’ responses are used for this study, and the constructs involved for analysis purpose are affect, social factor, facilitating conditions, perceived financial benefits and perceived risk constructs.FindingsThe finding suggests a significant positive association for social factor and perceived risk, while negative association learnt for affect on acceptance of Ar-Rahnu financing. On the same note, the facilitating condition and perceived financial benefit are found insignificantly related.Practical implicationsThe findings generated from this study are expected to enrich the literature on the body of knowledge, as it has served to broaden the understanding of the Ar-Rahnu acceptance level in Malaysia. As mentioned, there is limited literature available using this type of financing. Existing studies focus too much on conventional financing products such as personal financing, credit card, short-term loan and many others. Less attention is given to Ar-Rahnu financing. Thus, this study expected to add value to the literature available in the context of Islamic pawn broking business. Moreover, the findings of this study will be very helpful for the Islamic financial institutions to find the best way to retain Ar-Rahnu clients and encourage more client to choose Ar-Rahnu as a mode of financing.Originality/valueThis study owns greater potential to assist Islamic financial institutions to discover the best techniques to retain and encourage the grander number of clients for Ar-Rahnu as a mode of financing.
Do FEARS drive Bitcoin?
Authors: Burggraf Tobias , Huynh Toan Luu Duc , Rudolf Markus , Wang Mei 
Published: May 2020

PurposeThis study examines the prediction power of investor sentiment on Bitcoin return.Design/methodology/approachWe construct a Financial and Economic Attitudes Revealed by Search (FEARS) index using search volume from Google's search engine to reveal household-level (“bankruptcy”, “unemployment”, “job search”, etc.) and market-level sentiment (“bankruptcy”, “unemployment”, “job search”, etc.).FindingsUsing a variety of quantitative methodologies such as the transfer entropy model as well as threshold regression and OLS, GLS and 2SLS estimations, we find that (1) investor sentiment has strong predictive power on Bitcoin, (2) household-level sentiment has larger effects than market-level sentiment and (3) the impact of sentiment is greater in low sentiment regimes than in high sentiment regimes. Based on these information, we build a hypothetical trading strategy that outperforms a simple buy-and-hold strategy both on an absolute and risk-adjusted basis. The results are consistent across cryptocurrencies and regions.Research limitations/implicationsThe findings contribute to the ongoing debate in the literature on the efficiency of cryptocurrency markets. The results reveal that the Bitcoin market is not efficient in the sense of the efficient market hypothesis – asset prices do not fully reflect all available information and we were able to “beat the market”. In addition, it sheds further light on the debate whether Bitcoin can be considered a medium of exchange, i.e. a currency or an investment product. Because investors are reallocating their Bitcoin holdings during times of increased market sentiment due to liquidity needs, they obviously consider bitcoin an investment product rather than a currency.Originality/valueThis study is the first to examine the impact of investor sentiment measured by FEARS on Bitcoin return.
Anlotinib can overcome acquired resistance to EGFR‐TKIs via FGFR1 signaling in non‐small cell lung cancer without harboring EGFR T790M mutation
Authors: Lian Zengzhi , Du Wenwen , Zhang Yang , Fu Yulong , Liu Ting , Wang Anqi , Cai Tingting , Zhu Jianjie , Zeng Yuanyuan , Liu Zeyi , Huang Jian‐an 
Published: May 2020

BackgroundAlthough many studies have defined mechanisms of resistance to EGFR‐TKIs, acquired resistance remains the major limitation of monotherapy with EGFR‐TKIs.MethodsCell viability was analyzed using a Cell Counting Kit‐8 (CCK‐8) assay. EGFR T790M mutation was sequenced on a HiSeq 4000 platform. mRNAs from HCC827 and HCC827 gefitinib‐resistant (GR) cells were analyzed by genome analyzer‐based deep sequencing. The effect of anlotinib on apoptosis and cell cycle arrest of HCC827 GR was detected by fluorescence‐activated cell sorting (FACS) analysis. A mouse xenograft model was used to assess the effect of anlotinib on HCC827 GR cells.ResultsThe T790M mutation was found in the PC‐9 GR cell line but not in the HCC827 GR cell line. Anlotinib could suppress the growth of HCC827 GR cells by inhibiting FGFR1 in vitro and in a mouse xenograft model. Moreover, FGFR1 was overexpressed in HCC827 GR cells, and the knockdown of FGFR1 reversed gefitinib resistance in HCC827 GR cells. Furthermore, anlotinib induced apoptosis and cell cycle arrest in HCC827 GR cells by increasing the activity of Caspase‐3.ConclusionsFGFR1 overexpression could be the mechanism of EGFR‐TKI acquired resistance and anlotinib can suppresse the growth of EGFR‐TKI‐resistant NSCLC cells without T790M mutation.
AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans
Authors: Kuo Chen‐Ting , You Guan‐Ting , Jian Ying‐Jie , Chen Ting‐Shin , Siao Yu‐Chen , Hsu Ao‐Lin , Ching Tsui‐Ting 
Published: May 2020

AbstractStress granules (SGs) are nonmembranous organelles that are dynamically assembled and disassembled in response to various stressors. Under stressed conditions, polyadenylated mRNAs and translation factors are sequestrated in SGs to promote global repression of protein synthesis. It has been previously demonstrated that SG formation enhances cell survival and stress resistance. However, the physiological role of SGs in organismal aging and longevity regulation remains unclear. In this study, we used TIAR‐1::GFP and GTBP‐1::GFP as markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF‐1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK‐eEF2K signaling is required for starvation and DR‐induced SG formation but not heat shock. Moreover, our data suggest that this AMPK‐eEF2K pathway‐mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced insulin/IGF‐1 signaling. Collectively, our findings unveil a novel role of SG formation in DR‐induced longevity.
Mortality in adults with chronic hepatitis B infection in the United States: a population‐based study
Authors: Zhou Kali , Dodge Jennifer L. , Grab Joshua , Poltavskiy Eduard , Terrault Norah A. 
Published: May 2020

SummaryBackgroundChronic hepatitis B infection is an important contributor to mortality in the United States, yet impact of available and effective oral antivirals on mortality among infected individuals is unknown.AimsTo compare risks and predictors of mortality in a recent time period between those with chronic, prior and no hepatitis B infection.MethodsThis is a population‐based cohort study of National Health and Nutrition Examination Surveys participants between 1999 and 2014 linked to National Death Index data. Adults aged 20 years or older with hepatitis B serologic testing were included. Outcomes of all‐cause and liver‐related mortality were evaluated using Cox regression.ResultsOf 39 206 participants, 192 (0.5%) had chronic and 2694 (6.9%) had prior hepatitis B infection. The all‐cause age/sex‐standardised mortality rates for chronic, prior and uninfected were 21.4, 15.1 and 11.8 per 1000 person‐years respectively. Liver‐related mortality occurred at respective rates of 4.1, 0.3 and 0.1 per 1000 person‐years. In multivariable analyses, those with chronic infection had 1.9‐fold (95% CI 1.1‐3.3) increased hazard of all‐cause mortality and 13.3‐fold (95% CI 3.9‐45.5) increased hazard of liver‐related mortality compared to uninfected. Predictors of all‐cause mortality among chronic infection included heavy alcohol use (HR 18.3, 95% CI 3.3‐100.6) and higher alanine aminotransferase (HR 1.02, 95% CI 1.00‐1.03).ConclusionsMortality among adults living with chronic hepatitis B infection still exceeds that of uninfected despite availability of improved therapeutics. Identification of chronic infection, initiation of treatment among eligible and modulation of co‐factors for disease progression are needed to improve survival.
Using learning analytics in the Amazonas: understanding students’ behaviour in introductory programming
Authors: Pereira Filipe D. , Oliveira Elaine H. T. , Oliveira David B. F. , Cristea Alexandra I. , Carvalho Leandro S. G. , Fonseca Samuel C. , Toda Armando , Isotani Seiji 
Published: May 2020

AbstractTools for automatic grading programming assignments, also known as Online Judges, have been widely used to support computer science (CS) courses. Nevertheless, few studies have used these tools to acquire and analyse interaction data to better understand the students’ performance and behaviours, often due to data availability or inadequate granularity. To address this problem, we propose an Online Judge called CodeBench, which allows for fine‐grained data collection of student interactions, at the level of, eg, keystrokes, number of submissions, and grades. We deployed CodeBench for 3 years (2016–18) and collected data from 2058 students from 16 introductory computer science (CS1) courses, on which we have carried out fine‐grained learning analytics, towards early detection of effective/ineffective behaviours regarding learning CS concepts. Results extract clear behavioural classes of CS1 students, significantly differentiated both semantically and statistically, enabling us to better explain how student behaviours during programming have influenced learning outcomes. Finally, we also identify behaviours that can guide novice students to improve their learning performance, which can be used for interventions. We believe this work is a step forward towards enhancing Online Judges and helping teachers and students improve their CS1 teaching/learning practices.
Checkpoint blockade treatment sensitises relapsed/refractory non‐Hodgkin lymphoma to subsequent therapy
Authors: Carreau Nicole A. , Armand Philippe , Merryman Reid W. , Advani Ranjana H. , Spinner Michael A. , Herrera Alex F. , Ramchandren Radhakrishnan , Hamid Muhammad S. , Assouline Sarit , Santiago Raoul , Wagner‐Johnston Nina , Paul Suman , Svoboda Jakub , Bair Steven M. , Barta Stefan K. , Nathan Sunita , Karmali Reem , Torka Pallawi , David Kevin , Lansigan Frederick , Persky Daniel , Godfrey James , Chavez Julio C. , Xia Yuhe , Diefenbach Catherine 
Published: May 2020

SummaryPatients with relapsed/refractory (R/R) non‐Hodgkin lymphoma (NHL) have limited options for salvage, and checkpoint blockade therapy (CBT) has little efficacy. Usage in solid malignancies suggests that CBT sensitises tumours to subsequent chemotherapy. We performed the first analysis of CBT on subsequent NHL treatment. Seventeen North American centres retrospectively queried records. The primary aim was to evaluate the overall response rate (ORR) to post‐CBT treatment. Secondary aims included progression‐free survival (PFS), duration of response (DOR) and overall survival (OS). Fifty‐nine patients (68% aggressive NHL, 69% advanced disease) were included. Patients received a median of three therapies before CBT. Fifty‐three (90%) discontinued CBT due to progression. Post‐CBT regimens included chemotherapy (49%), targeted therapy (30%), clinical trial (17%), transplant conditioning (2%) and chimeric antigen receptor T cell (CAR‐T) therapy (2%). The ORR to post‐CBT treatment was 51%, with median PFS of 6·1 months. In patients with at least stable disease (SD) to post‐CBT, the median DOR was significantly longer than to pre‐CBT (310 vs. 79 days, P = 0·005) suggesting sensitisation. Nineteen patients were transplanted after post‐CBT therapy. Median overall survival was not reached, nor affected by regimen. Prospective trials are warranted, as this may offer R/R NHL patients a novel therapeutic approach.
Pandemics and Supply Chain Management Research: Toward a Theoretical Toolbox*
Authors: Craighead Christopher W. , Ketchen David J. , Darby Jessica L. 
Published: May 2020

ABSTRACTThe COVID‐19 pandemic paralyzed the world and revealed the critical importance of supply chain management—perhaps more so than any other event in modern history—in navigating crises. The extensive scope of disruption, massive spillover of effects across countries and industries, and extreme shifts in demand and supply that occurred during the COVID‐19 pandemic illustrate that pandemics are qualitatively different from typical disruptions. As such, pandemics require scholars to take a fresh look at what lenses offer understanding of supply chain phenomena in order to help supply chain managers better prepare for the next pandemic and foster transiliency (i.e., the ability to simultaneously restore some processes and change—often radically—others). To help scholars and managers achieve these aims, we offer an agenda for supply chain management research on pandemics by considering how the key tenets of well‐known and emergent theories can illuminate challenges and potential solutions. Specifically, we consider how resource dependence theory, institutional theory, resource orchestration theory, structural inertia, game theory, real options theory, event systems theory, awareness–motivation–capability framework, prospect theory, and tournament theory offer ideas that can help scholars build knowledge about pandemics’ effects on supply chains as well as help managers formulate responses.
Leaf size of woody dicots predicts ecosystem primary productivity
Authors: Li Yaoqi , Reich Peter B. , Schmid Bernhard , Shrestha Nawal , Feng Xiao , Lyu Tong , Maitner Brian S. , Xu Xiaoting , Li Yichao , Zou Dongting , Tan Zheng‐Hong , Su Xiangyan , Tang Zhiyao , Guo Qinghua , Feng Xiaojuan , Enquist Brian J. , Wang Zhiheng 
Published: May 2020

AbstractA key challenge in ecology is to understand the relationships between organismal traits and ecosystem processes. Here, with a novel dataset of leaf length and width for 10 480 woody dicots in China and 2374 in North America, we show that the variation in community mean leaf size is highly correlated with the variation in climate and ecosystem primary productivity, independent of plant life form. These relationships likely reflect how natural selection modifies leaf size across varying climates in conjunction with how climate influences canopy total leaf area. We find that the leaf size‒primary productivity functions based on the Chinese dataset can predict productivity in North America and vice‐versa. In addition to advancing understanding of the relationship between a climate‐driven trait and ecosystem functioning, our findings suggest that leaf size can also be a promising tool in palaeoecology for scaling from fossil leaves to palaeo‐primary productivity of woody ecosystems.
Experimental tests of a seasonally changing visual preference for habitat in a long‐distance migratory shorebird
Authors: Kok Eva M. A. , Hogan Jerry A. , Piersma Theunis 
Published: May 2020

AbstractMigratory shorebirds show highly organized seasonal cycles in physiological and morphological traits (body mass and composition, plumage, hormone levels, etc.), which in captivity is accompanied by restless behaviour at times when free‐living birds would start migration. We introduce the idea that seasonally changing preference for habitat could motivate migrants to embark on migration and that this cognitive process could also guide them to seasonally appropriate places. We explored this by testing whether red knots (Calidris canutus), which also in captivity maintain marked circannual phenotypic rhythms, show evidence of seasonal change in preference for pictures of seasonally appropriate habitats. We first developed a method to verify whether red knots are able to memorize and discriminate contrasting pictures projected by LCD projectors. This was followed by two different experiments in which we tested for a seasonally changing preference for breeding or non‐breeding habitat. When carried out during the pre‐breeding season, the red knots are expected to prefer pictures of mudflats, their non‐breeding habitat. At the start of the breeding season, they should prefer pictures of the tundra breeding habitat. We established that knots are able to distinguish and memorize projected images. We failed to demonstrate the predicted change in vision‐based habitat preference, but for reasons of test design we do not interpret this as a strong rejection of the hypothesis. Instead, we suggest that experiments with greater numbers of individuals tested once, perhaps in combination with the provision of additional cues such as smells and sounds, will help the development of these ideas further.
Grazing by large herbivores improves soil microbial metabolic activity in a meadow steppe
Authors: Qu Tongbao , Guo Weiqiang , Yang Chengxi , Zhang Jianfeng , Yang Yurong , Wang Deli 
Published: May 2020

AbstractLarge herbivores grazing is a major disturbance that can cause significant changes of soil environment in grassland ecosystems. However, it remains unclear how soil microbial metabolic activity responses to different grazing intensities. We analyzed the relationships between soil microbial carbon source utilization and grazing intensity, and further assessed the main factors determining soil microbial metabolic activity in a meadow steppe. Soil samples were analyzed along different grazing intensities (no grazing, light grazing and heavy grazing) with community‐level physiological profiles (CLPP) using Biolog Eco‐plates incubation to estimate soil microbial carbon source utilization patterns. Redundancy analysis (RDA) was performed to explore the major factors influencing soil microbial metabolic activity in a five‐year grazing grassland in northeast of China. Grazing significantly improved soil microbial community carbon utilization and increased utilization of carbohydrates, amino acids, phenolic acids and amines, while significantly decreased utilization of carboxylic acids. Among edaphic properties and plant traits, plant density, total biomass (TB), soil water content (SW) and C:N ratio (C/N) were main driving forces contributing to the carbon source utilization structure of the soil microbial communities. Soil microbial metabolic activity was promoted by grazing through altering plant traits and abiotic soil properties, and soil‐related factors were primary and direct driving force for soil microbial metabolic activity in grasslands of northeast China. The present study demonstrated differential soil microbial responses along grazing intensities and has important applications for better management practices in the grassland ecosystem.
Use of human amniotic membrane repair of anterior urethral defect: First clinical report
Authors: Razzaghi Mohammadreza , Rahavian Amirhossein , Fallah Karkan Morteza , Allameh Farzad , Ghiasy Saleh , Javanmard Babak 
Published: May 2020

ObjectiveTo evaluate the use of human amniotic membrane allograft to prevent urethrocutaneous fistula after tubularized incised plate repair for redo‐hypospadias and anterior urethral defects.MethodsThis pilot study included 28 patients (mean age 25.3 ± 11 years) with a history of previous failed hypospadia repair, who underwent tubularized incised plate urethroplasty in one session by the same surgical team from April 2016 to April 2019. After the reconstruction of a neourethra and proper hemostasis, a human amniotic membrane allograft – Grafting Scaffold – was used to cover the suture lines.ResultsThe mean follow‐up time was 13.3 ± 4.5 months. Two urethrocutaneous fistulas occurred within the first 2 weeks after the surgery, one of which was caused by the infection of the surgical site. No penile torsion, urethral diverticula, meatal stenosis or glans dehiscence was reported.ConclusionsAmniotic membrane graft provides an applicable, low‐cost, feasible, biodegradable and safe second cover in redo‐hypospadias repairs by tubularized incised plate technique. Its use is technically easy; it has satisfactory cosmetic outcomes and might decrease urethrocutaneous fistula formation.
Aeromedical retrievals for gastrointestinal disorders in rural and remote Australia: the need for improved access to specialist advice
Authors: Gardiner Fergus W. , Bishop Lara , McMahon Kathryn , Nwose Ezekiel U. , Connor Susan , Begun Jakob , Andrews Jane M. 
Published: May 2020

AbstractThe Royal Flying Doctor Service (RFDS) provides medical care to populations without access to traditional health‐care services. From 2014 to 2018 the RFDS conducted 6007 (≈1201/year) aeromedical retrievals for gastrointestinal (GI) disorders. More detailed research is needed to determine specific GI disorders that contributed to this caseload, and in particular inform whether the establishment of a GI specialist service is justified.
Real story behind transvaginal mesh
Authors: King Jenny 
Published: May 2020

AbstractMuch of the debate over the use of transvaginal mesh for incontinence and prolapse has been conducted on social media, in the tabloid press and through a very public Senate inquiry. It has been a very emotionally charged debate with surgeons variously accused of scandalous behavior, financial impropriety, surgical experimentation and misogyny. What really happened, how did we get here and what can we learn from these complex events?