bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes
Authors: Li Jin , Pan Xiaohan , Pan Guihua , Song Zijun , He Yao , Zhang Susu , Ye Xueru , Yang Xiang , Xie Enjun , Wang Xinhui , Mai Xudong , Yin Xiangju , Tang Biyao , Shu Xuan , Chen Pengyu , Dai Xiaoshuang , Tian Ye , Yao Liheng , Han Mulan , Xu Guohuan , Zhang Huijie , Sun Jia , Chen Hong , Wang Fudi , Min Junxia , Xie Liwei 
Published: April 2020

AbstractIron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown. Using integrative analyses of multi‐omics data, transferrin receptor 1 (Tfr1) is identified as a candidate for regulating thermogenesis in beige adipocytes. Furthermore, it is shown that mice lacking Tfr1 specifically in adipocytes have impaired thermogenesis, increased insulin resistance, and low‐grade inflammation accompanied by iron deficiency and mitochondrial dysfunction. Mechanistically, the cold treatment in beige adipocytes selectively stabilizes hypoxia‐inducible factor 1‐alpha (HIF1α), upregulating the Tfr1 gene, and thermogenic adipocyte‐specific Hif1α deletion reduces thermogenic gene expression in beige fat without altering core body temperature. Notably, Tfr1 deficiency in interscapular brown adipose tissue (iBAT) leads to the transdifferentiation of brown preadipocytes into white adipocytes and muscle cells; in contrast, long‐term exposure to a low‐iron diet fails to phenocopy the transdifferentiation effect found in Tfr1‐deficient mice. Moreover, mice lacking transmembrane serine protease 6 (Tmprss6) develop iron deficiency in both inguinal white adipose tissue (iWAT) and iBAT, and have impaired cold‐induced beige adipocyte formation and brown fat thermogenesis. Taken together, these findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron‐dependent and iron‐independent mechanisms.
Heterostructure SnSe2/ZnSe@PDA Nanobox for Stable and Highly Efficient Sodium‐Ion Storage
Authors: Liu Pei , Han Jun , Zhu Kunjie , Dong Zihao , Jiao Lifang 
Published: April 2020

AbstractRationally designed electrode materials with high capacity, long cycle life, and low cost are indispensable for sodium‐ion batteries. Herein, a hierarchical nanobox consisting of a heterojunction bimetallic selenide yolk and polydopamine shell (denoted as SnSe2/ZnSe@PDA) is engineered and fabricated successfully. Owing to the charge redistribution and lattice distortion at the hetero‐phase boundaries, Na+ ions can be easily adsorbed and transferred swiftly, facilitating the reaction kinetics and promoting cycling behavior. By means of the hollow structure and elastic polymer shell, this approach can synergistically alleviate volume fluctuation and the aggregation of active nanomaterials during cycling. This material delivers a high reversible capacity of 616 mA h g‐1 at 1 A g‐1 over 1000 long‐term cycles, and superior rate capability, which provides more possibilities for the practical applications of energy storage in the future.
Relief pain of symptomatic annular pancreas in adults: A report of two cases
Authors: Shie Chang‐Bih , Lu I‐Cheng , Wu I‐Ting 
Published: April 2020

AbstractAnnular pancreas is a rare disease and was first described by Tiedman in 1818. The anomaly is often discovered in neonates or during the first year of life. The clinical presentation can be less severe in the case of young children, and the anomaly can remain asymptomatic and may be discovered fortuitously in adult patients. In adult patients with annular pancreas, the common symptoms include cramping epigastric pain and postprandial abdominal fullness. Associated conditions include duodenal ulcers, acute pancreatitis, carcinoma of the pancreatic head, biliary colic in association with biliary obstruction and jaundice, and obstruction of the gastric outlet. Here, we successfully treated the cases of two adult patients with symptomatic annular pancreas, and we discuss the available diagnostic and therapeutic modalities for the same.
The association ofNative Americangenetic ancestry and high‐density lipoprotein cholesterol: A representative study of a highly admixed population
Authors: Fritz Jimena , Lopez‐Ridaura Ruy , Choudhry Shweta , Razo Christian , Lamadrid‐Figueroa Hector 
Published: April 2020

AbstractObjectiveHispanic populations typically show a high prevalence of dyslipidemias, especially of low high‐density lipoproteins (HDLs) or HDL cholesterol. Highly admixed populations are ideal groups to clarify the role of genetic ancestry on HDL concentrations, isolating it from that of other factors. The objective of this study was to estimate the association between Native American genetic ancestry and HDL‐cholesterol levels independent of socioeconomic factors in a representative sample of the Mexican population.MethodsWe used data from the Mexican National Health Survey 2000, analyzing 1647 subjects from whom stored DNA samples and HDL measurements were available. To estimate proportional genetic ancestry (Native American, African, and European), we used a 107 genetic ancestry informative marker panel with the software STRUCTURE. To estimate the association between genetic ancestry and low HDL levels, we fitted logistic regression models with the percentage of Native American genetic ancestry, in quartiles, as the main predictor.ResultsMean HDL levels were 38.9 mg/dL, with 62% of subjects having levels below 40 mg/dL. Participants had on average 53.6% Native American, 39% European, and 7.3% African genetic ancestry. Those in the fourth quartile of Native American genetic ancestry had 35% higher odds of having low HDL‐cholesterol relative to those in the first quartile (odds ratio, 1.35; 95% confidence interval, 0.99‐1.81) after adjustment for socioeconomic level and other covariates, although the association is clearly nonlinear.ConclusionNative American genetic ancestry seems to play a small but distinct role in the development of low HDL cholesterol levels.
Ruthenium(II)‐ and Copper(II)‐Mediated Synthesis of Trisubstituted Pyrroles from Isoxazoles and Acrylate Esters
Authors: Kumar Pravin , Kapur Manmohan 
Published: April 2020

AbstractAn efficient ruthenium(II)‐ and copper(II)‐mediated, “one‐pot” synthesis of pyrroles has been reported. The reaction most probably proceeds via a reductive cleavage of isoxazoles. This protocol results in the synergistic formation of new C−C, C−N bonds, which leads to a simple and an efficient method for the synthesis of highly functionalized pyrroles from isoxazoles and acrylate esters.
Cucurbit[n]uril‐Based Supramolecular Frameworks Assembled through Outer‐Surface Interactions
Authors: Huang Ying , Gao Rui‐Han , Liu Ming , Chen Li‐Xia , Ni Xin‐Long , Xiao Xin , Cong Hang , Zhu Qian‐Jiang , Chen Kai , Tao Zhu 
Published: April 2020

AbstractPorous materials, especially metal–organic frameworks, covalent organic frameworks, and supramolecular organic frameworks, are widely used in heterogeneous catalysis, adsorption, and ion exchange. Cucurbit[n]urils (Q[n]s) suitable building units for porous materials because they possess cavities with neutral electrostatic potential, portal carbonyls with negative electrostatic potential, and outer surfaces with positive electrostatic potential, which may result in the formation of Q[n]‐based supramolecular frameworks (QSFs) assembled through the interaction of guests within Q[n]s, the coordination of Q[n]s with metal ions, and outer‐surface interaction of Q[n]s (OSIQ). This review summarizes the various QSFs assembled via OSIQs. The QSFs can be classified as being assembled by 1) self‐induced OSIQ, 2) anion‐induced OSIQ, and 3) aromatic‐induced OSIQ. The design and construction of QSFs with novel structures and specific functional properties may establish a new research direction in Q[n] chemistry.
Atomically Dispersed Nickel(I) on an Alloy‐Encapsulated Nitrogen‐Doped Carbon Nanotube Array for High‐Performance Electrochemical CO2 Reduction Reaction
Authors: Zhang Tianyu , Han Xu , Yang Hongbin , Han Aijuan , Hu Enyuan , Li Yaping , Yang Xiao‐qing , Wang Lei , Liu Junfeng , Liu Bin 
Published: April 2020

AbstractSingle‐atom catalysts (SACs) show great promise for electrochemical CO2 reduction reaction (CRR), but the low density of active sites and the poor electrical conduction and mass transport of the single‐atom electrode greatly limit their performance. Herein, we prepared a nickel single‐atom electrode consisting of isolated, high‐density and low‐valent nickel(I) sites anchored on a self‐standing N‐doped carbon nanotube array with nickel–copper alloy encapsulation on a carbon‐fiber paper. The combination of single‐atom nickel(I) sites and self‐standing array structure gives rise to an excellent electrocatalytic CO2 reduction performance. The introduction of copper tunes the d‐band electron configuration and enhances the adsorption of hydrogen, which impedes the hydrogen evolution reaction. The single‐nickel‐atom electrode exhibits a specific current density of −32.87 mA cm−2 and turnover frequency of 1962 h−1 at a mild overpotential of 620 mV for CO formation with 97 % Faradic efficiency.
Electrosynthesis of Dihydropyrano[4,3‐b]indoles Based on a Double Oxidative [3+3] Cycloaddition
Authors: Choi Subin , Park Jinhwi , Yu Eunsoo , Sim Jeongwoo , Park Cheol‐Min 
Published: April 2020

AbstractOxidative [3+3] cycloadditions offer an efficient route for six‐membered‐ring formation. This approach has been realized based on an electrochemical oxidative coupling of indoles/enamines with active methylene compounds followed by tandem 6π‐electrocyclization leading to the synthesis of dihydropyrano[4,3‐b]indoles and 2,3‐dihydrofurans. The radical–radical cross‐coupling of the radical species generated by anodic oxidation combined with the cathodic generation of the base from O2 allows for mild reaction conditions for the synthesis of structurally complex heterocycles.
Molecular Sieving of C2‐C3 Alkene from Alkyne with Tuned Threshold Pressure in Robust Layered Metal–Organic Frameworks
Authors: Ke Tian , Wang Qingju , Shen Jin , Zhou Jingyi , Bao Zongbi , Yang Qiwei , Ren Qilong 
Published: April 2020

AbstractC2‐C3 alkyne/alkene separation is of great importance; however, designing materials for an efficient molecular sieving of alkenes from alkynes remains challenging. Now, two hydrolytically stable layered MOFs, [Cu(dps)2(GeF6)] (GeFSIX‐dps‐Cu, dps=4,4′‐dipyridylsulfide) and [Zn(dps)2(GeF6)] (GeFSIX‐dps‐Zn), can achieve almost complete exclusion of both C3H6 and C2H4 from their alkyne analogues. GeFSIX‐dps‐Cu displays a notable advanced threshold pressure for alkynes adsorption and thus substantial uptakes at lower pressures, providing record C3H4/C3H6 uptake ratios and capacity‐enhanced C2H2/C2H4 sieving for a wide composition range. Metal substitution (Zn to Cu) affords fine tuning of linker rotation and layer stacking, creating slightly expanded pore aperture and interlayer space coupled with multiple hydrogen‐bonding sites, allowing easier entrance of alkyne while excluding alkene. Breakthrough experiments confirmed tunable sieving by these MOFs for C3H4/C3H6 and C2H2/C2H4 mixtures.
Target‐Directed Azide‐Alkyne Cycloaddition for Assembling HIV‐1 TAR RNA Binding Ligands
Authors: Paul Rakesh , Dutta Debasish , Paul Raj , Dash Jyotirmayee 
Published: April 2020

AbstractThe highly conserved HIV‐1 transactivation response element (TAR) binds to the trans‐activator protein Tat and facilitates viral replication in its latent state. The inhibition of Tat–TAR interactions by selectively targeting TAR RNA has been used as a strategy to develop potent antiviral agents. Therefore, HIV‐1 TAR RNA represents a paradigmatic system for therapeutic intervention. Herein, we have employed biotin‐tagged TAR RNA to assemble its own ligands from a pool of reactive azide and alkyne building blocks. To identify the binding sites and selectivity of the ligands, the in situ cycloaddition has been further performed using control nucleotide (TAR DNA and TAR RNA without bulge) templates. The hit triazole‐linked thiazole peptidomimetic products have been isolated from the biotin‐tagged target templates using streptavidin beads. The major triazole lead generated by the TAR RNA presumably binds in the bulge region, shows specificity for TAR RNA over TAR DNA, and inhibits Tat–TAR interactions.
In Situ Pyrolysis Tracking and Real‐Time Phase Evolution: From a Binary Zinc Cluster to Supercapacitive Porous Carbon
Authors: Wang Yi‐Fan , Liang Yiyu , Wu Yan‐Fang , Yang Jian , Zhang Xu , Cai Dandan , Peng Xu , Kurmoo Mohamedally , Zeng Ming‐Hua 
Published: April 2020

AbstractThe in situ tracking of the pyrolysis of a binary molecular cluster [Zn7(μ3‐CH3O)6(L)6][ZnLCl2]2 is presented with one brucite disk and two mononuclear fragments (L=mmimp: 2‐methoxy‐6‐((methylimino)‐methyl)phenolate) to porous carbon using TG‐MS from 30 to 900 °C. Following up the spilled gas product during the decomposed reaction of zinc cluster along the temperature rising, and in conjunction with XRD, SEM, BET and other materials characterization, where three key steps were observed: 1) cleavage of the bulky external ligand; 2) reduction of ZnO and 3) volatilization of Zn. The real‐time‐dependent phase‐sequential evolution of the remaining products and the processing of pore forming template transformation are proposed simultaneously. The porous carbon structure featuring a uniform nano‐sized pore distribution synthesized at 900 °C with the highest surface area of 1644 m2 g−1 and pore volume of 0.926 cm3 g−1 exhibits the best known capacitance of 662 F g−1 at 0.5 A g−1.
Backbone‐Directed Self‐Assembly of Interlocked Molecular Cyclic Metalla[3]Catenanes
Authors: Feng Ting , Li Xin , An Yuan‐Yuan , Bai Sha , Sun Li‐Ying , Li Yang , Wang Yao‐Yu , Han Ying‐Feng 
Published: April 2020

AbstractThe efficient backbone‐directed self‐assembly of cyclic metalla[3]catenanes by the combination of tetrachloroperylenediimide (TCPDI)‐based dinuclear rhodium(III) clips and 4,4′‐diazopyridine or 4,4′‐dipyridylethylene ligands is realized in a single‐step strategy. The topology and coordination geometry of the cyclic metalla[3]catenanes are characterized by NMR spectroscopy, ESI‐TOF‐MS spectrometry, UV/Vis‐NIR spectroscopy, and X‐ray diffraction studies. The most remarkable feature of the formed cyclic metalla[3]catenane is that it contains π‐aggregates (ca. 2.6 nm) incorporating six TCPDIs. Further studies revealed that cyclic metalla[3]catenanes can be converted reversibly to their corresponding sodium adducts and precursor building blocks, respectively. This strategy opens the possibility of generating unique supramolecular structures from discrete functional π‐aggregates with precise arrangements.
Photo‐promoted Skeletal Rearrangement of Phosphine–Borane Frustrated Lewis Pairs Involving Cleavage of Unstrained C−C σ‐Bonds
Authors: Ito Tatsuyoshi , Iwasawa Nobuharu , Takaya Jun 
Published: April 2020

AbstractAn unprecedented photo‐promoted skeletal rearrangement reaction of phosphine–borane frustrated Lewis pairs, o‐(borylaryl)phosphines, involving cleavage of an unstrained sp2C–sp3C σ‐bond is reported. The reaction realizes an efficient synthesis of cyclic phosphonium borate compounds. The reaction mechanism via a boranorcaradiene intermediate is proposed based on theoretical calculations. This work sheds light on the new photoreactivity of phosphine–borane FLPs.
Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2‐Catalyzed Intramolecular [3+2] Cycloaddition
Authors: Jia Xuelei , Lei Honghui , Han Feipeng , Zhang Tao , Chen Ying , Xu Zhengshuang , Nakliang Pratanphorn , Choi Sun , Guo Yian , Ye Tao 
Published: April 2020

AbstractA concise and asymmetric total synthesis of five kopsane alkaloids that share a unique heptacyclic caged ring system was accomplished. The key transformation in the sequence involved a remarkable PtCl2‐catalyzed intramolecular [3+2] cycloaddition, which allowed for the rapid assembly of pentacyclic carbon skeletons bearing 2,3‐quaternary functionalized indoline. Expeditious construction of diverse indoline scaffolds with excellent control of diastereoselectivity demonstrated the broad scope and versatility of this key transformation.
Strain Influences the Hydrogen Evolution Activity and Absorption Capacity of Palladium
Authors: Jansonius Ryan P. , Schauer Phil A. , Dvorak David J. , MacLeod Benjamin P. , Fork David K. , Berlinguette Curtis P. 
Published: April 2020

AbstractStrain engineering can increase the activity and selectivity of an electrocatalyst. Tensile strain is known to improve the electrocatalytic activity of palladium electrodes for reduction of carbon dioxide or dioxygen, but determining how strain affects the hydrogen evolution reaction (HER) is complicated by the fact that palladium absorbs hydrogen concurrently with HER. We report here a custom electrochemical cell, which applies tensile strain to a flexible working electrode, that enabled us to resolve how tensile strain affects hydrogen absorption and HER activity for a thin film palladium electrocatalyst. When the electrodes were subjected to mechanically‐applied tensile strain, the amount of hydrogen that absorbed into the palladium decreased, and HER electrocatalytic activity increased. This study showcases how strain can be used to modulate the hydrogen absorption capacity and HER activity of palladium.
Achieving Superior Electrocatalytic Performance by Surface Copper Vacancy Defects during Electrochemical Etching Process
Authors: Guo Niankun , Xue Hui , Bao Amurisana , Wang Zihong , Sun Jing , Song Tianshan , Ge Xin , Zhang Wei , Huang Keke , He Feng , Wang Qin 
Published: April 2020

AbstractVacancy defects of catalysts have been extensively studied and proven to be beneficial to various electrocatalytic reactions. Herein, an ultra‐stable three‐dimensional PtCu nanowire network (NNW) with ultrafine size, self‐supporting rigid structure, and Cu vacancy defects has been developed. The vacancy defect‐rich PtCu NNW exhibits an outstanding performance for the oxygen reduction reaction (ORR), with a mass activity 14.1 times higher than for the commercial Pt/C catalyst (20 %.wt, JM), which is currently the best performance. The mass activity of the PtCu NNW for methanol oxidation reaction (MOR) is 17.8 times higher than for the commercial Pt/C catalyst. Density‐functional theory (DFT) calculations indicate that the introduction of Cu vacancies enhances the adsorption capacity of Pt atoms to the HO* intermediate and simultaneously weakens the adsorption for the O* intermediate. This work presents a facile strategy to assemble efficient electrocatalysts with abundant vacancy defects, at the same time, provides an insight into the ORR mechanism in acidic solution.
Revisiting the Limiting Factors for Overall Water‐Splitting on Organic Photocatalysts
Authors: Rahman Mohammad , Tian Haining , Edvinsson Tomas 
Published: April 2020

AbstractIn pursuit of inexpensive and earth abundant photocatalysts for solar hydrogen production from water, conjugated polymers have shown potential to be a viable alternative to widely used inorganic counterparts. The photocatalytic performance of polymeric photocatalysts, however, is very poor in comparison to that of inorganic photocatalysts. Most of the organic photocatalysts are active in hydrogen production only when a sacrificial electron donor (SED) is added into the solution, and their high performances often rely on presence of noble metal co‐catalyst (e.g. Pt). For pursuing a carbon neutral and cost‐effective green hydrogen production, unassisted hydrogen production solely from water is one of the critical requirements to translate a mere bench‐top research interest into the real world applications. Although this is a generic problem for both inorganic and organic types of photocatalysts, organic photocatalysts are mostly investigated in the half‐reaction, and have so far shown limited success in hydrogen production from overall water‐splitting. To make progress, this article exclusively discusses critical factors that are limiting the overall water‐splitting in organic photocatalysts. Additionally, we also have extended the discussion to issues related to stability, accurate reporting of the hydrogen production as well as challenges to be resolved to reach 10 % STH (solar‐to‐hydrogen) conversion efficiency.
Evaluation of a vacuum collection system in the preparation of PAN fibers by forcespinning for application in ultrafine particle filtration
Authors: Salussoglia Ana Isabela Pianowski , Tanabe Eduardo Hiromitsu , Aguiar Mônica Lopes 
Published: April 2020

AbstractThis study investigates the use of a vacuum collection system (VCS) in the forcespinning formation of polyacrylonitrile fibers. The surface of different filter media (substrates) has been modified for air filtration applications. The evaluation was made of the effects of collection time (60 and 180 s), VCS power (25, 50, 75, and 100%), needle size (30G ½″ and 26G ½″), and rotation speed (4,000 and 6,000 rpm). The main results were that higher substrate permeability constant in association with VCS led to a decrease in the porosity of the fiber layer, an increase of the VCS power led to increases in the collection efficiency and pressure drop, while the superficial porosity and fiber diameter decreased, and fiber collection time analysis showed that the longer collection time led to higher fiber diameter and smaller pressure drop. In all cases, the addition of the fiber layer caused increases in the pressure drop and collection efficiency, together with decreased permeability constant. Although the collection efficiency values for nanoparticles are not as expressive, these results are encouraging and indicate that VCS can be used to improve the performance of the filter medium.
Preparation of imidazole embedded polyurea microcapsule for latent curing agent
Authors: Zhao Liyang , Yang Xiaojun , Ma Limin , Li Qingyang 
Published: April 2020

AbstractThe IZ‐PU microcapsule‐type curing agent was prepared by interfacial polymerization method. The shell‐core structure of the IZ‐PU microcapsules was demonstrated by IR and SEM. The core content and coating efficiency of the IZ‐PU microcapsules were analyzed by DSC test of the one‐component adhesive consisting of IZ‐PU microcapsules and epoxy resin. The results showed that the IZ‐PU microcapsules is a proper latent curing agent to epoxy resin, its latency at room temperature is longer than 30 days.