bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confucianism, growth and democracy
Authors: Ma Tay-Cheng , Ouyang Lishu 
Published: May 2020

PurposeThe purpose of this article is to investigate the impact of Confucianism on growth under different political regimes.Design/methodology/approachThe empirical specification adopts a two-regime panel threshold model proposed by Hansen (1999) to endogenously divide our country sample into two-regime-types – autocracy and democracy – according to a country's democratic stock or experiences.FindingsThe results show that the effect of Confucianism on growth exhibits an asymmetrical pattern depending on the status of a country's political democracy. Only when a moderate level of freedom has already been attained can Confucianism have a positive effect on growth. Conversely, for autocracies whose democratic institutions cannot pass a certain threshold, Confucianism has a very limited effect in terms of changing economic activity.Research limitations/implicationsIf the data with different sample years and/or different sample countries are used, the research results may lack generalizability. Further tests of the two-regime model with different data sizes are encouraged.Originality/valueThe authors use the World Values Survey (WVS) map to identify the countries under the influence of Confucianism. The authors emphasize that focusing only on political geography may overlook the information from the spread of cultural traits that accompanied the migration of people. So, based on the Confucian countries suggested by the WVS and the migration matrix of Putterman and Weil (2010), an immigration-based Confucianism variable was constructed. To accommodate different effects of Confucianism on growth in different phases of political development, the empirical specification adopts an asymmetrical pattern to investigate the impact of Confucianism on economic performance.
Regional entrepreneurial ecosystems in Chile: comparative lessons
Authors: Villegas-Mateos Allan 
Published: May 2020

PurposeThis paper aims to deal with different experts’ perceptions of entrepreneurial ecosystems (EEs) from central to non-central regions to evaluate if there was any evolution (or involution), comparing the results with those of a previous similar study on Chile from 2013, and it follows to replicate and improve our knowledge of the entrepreneurial opportunities.Design/methodology/approachOne of the Global Entrepreneurship Monitor surveys, the National Experts’ Survey, was applied to a sample ofN= 1,555 key informants in Chile at 11 regions. The author used non-parametric statistics to compare the differences between centrally and non-centrally located experts.FindingsThe results indicate an evolution of the Chilean entrepreneurial ecosystem in an effort to homologate the entrepreneurial opportunities at non-central regions since the last study published in 2013. The financial support and physical infrastructure conditions were perceived to be more favorable in central regions, whereas the general government policies and entrepreneurial education at primary and secondary levels were perceived to be more favorable in non-central regions.Originality/valueThis research aims to contribute to filling the gap from the regional EEs’ perspective in emerging economies by comparing the results of the study on Chile with data from the previous government (2007–2009) providing an updated study of it (2015–2018) using the entrepreneurial framework conditions. It is relevant because the government established the “StartUp Chile” program that positioned the country as an innovation hub in Latin America since 2010.
Victor Lebow: an unknown critical marketer
Authors: Benton, Jr Raymond 
Published: May 2020

PurposeThe purpose of this paper is to draw attention to Victor Lebow, an unknown contributor to critical marketing studies. The paper also contributes to the literature on marketing amnesia. A brief biography of Lebow is presented in which it is established that he was a marketing professional. The paper then discusses his unacknowledged contribution to critical thought by exploring his only book.Design/methodology/approachThe paper is based on a close reading of Lebow’s only book, contextualizing it by placing it in historical context. The paper uses a traditional historical narrative approach to present the results.FindingsIt is pointed out that the business system, including marketing, is riven with power relations that are largely unappreciated or ignored. Woven into Lebow’s account is an attempt to rethink aspects of theory, practice and especially institutions that had and have assumed a taken-for-granted status. It is established that Lebow’s thought, as a marketing professional, went well beyond typical marketing. He presents an interesting and innovative program for converting private enterprise into a socially responsible structure without resulting to any form of socialism.Originality/valueNo such review or evaluation of Victor Lebow has been published. One 1955 article has been frequently cited. His wider thought has been ignored.
Knowledge and capabilities for products/services development: the UK spin-off firms context
Authors: Baines Ning , Lawton Smith Helen 
Published: May 2020

PurposeThis paper aims to explore and propose the skills and capabilities required in developing products and services within UK university spin-offs (USOs) by considering the model of products/services development (Verona, 1999).Design/methodology/approachMixed methods of 20 in-depth interviews and questionnaire survey with 204 founders of USOs were used in this study.FindingsThe findings contribute in filling the literature gap by proposing key knowledge and capabilities required to develop products/services within the unique and non-commercial context, in which USOs are created by academics who do not necessarily have entrepreneurial or business experience.Originality/valueThis research contributes to studies of product/service development by proposing a modification of elements within the existing theoretical model to be applicable to the specific firm and country context, such as USOs in the UK. Further, the study extends knowledge on the interplay between knowledge management and product development. The applications of the findings are that they can inform academic entrepreneurs on the capabilities significant in the development process. They can also act as indicators to technology transfer offices in what is needed for the provision of appropriate support and training to academic founders/entrepreneurs to foster and enhance other entrepreneurial activities.
Health literacy and its effects on well-being: how vulnerable healthcare service users integrate online resources
Authors: Virlée Justine , van Riel Allard C.R. , Hammedi Wafa 
Published: May 2020

Purpose
This study aims to develop a better understanding of how online health community (OHC) members with different health literacy (HL) levels benefit from their participation, through the analysis and comparison of their resource integration (RI) processes. It investigates through a RI lens how the vulnerability of community members – captured as their level of HL – affects the benefits they derive from participation.

Design/methodology/approach
Quantitative and qualitative methods were used to investigate the effects of healthcare service users’ vulnerability. Data were collected about their profiles and levels of HL. Furthermore, 15 in-depth interviews were conducted.

Findings
The study demonstrates how low levels of HL act as a barrier to the integration of available online health resources. Participation in OHCs appears less beneficial for vulnerable users. Three types of benefits were identified at the individual level, namely, psychological quality-of-life, physical quality-of-life and learning. Benefits identified at the community level were: content generation and participation in the development of the community.

Originality/value
This study has implications for the understanding of how service users’ activities affect their own outcomes and how the vulnerability of users could be anticipated and considered in the design of the community.
Blockchain: case studies in food supply chain visibility
Authors: Rogerson Michael , Parry Glenn C. 
Published: May 2020

Purpose
This paper aims to investigate how blockchain has moved beyond cryptocurrencies and is being deployed to enhance visibility and trust in supply chains, their limitations and potential impact.

Design/methodology/approach
Qualitative analysis are undertaken via case studies drawn from food companies using semi-structured interviews.

Findings
Blockchain is demonstrated as an enabler of visibility in supply chains. Applications at scale are most likely for products where the end consumer is prepared to pay the premium currently required to fund the technology, e.g. baby food. Challenges remain in four areas: trust of the technology, human error and fraud at the boundaries, governance, consumer data access and willingness to pay.

Research limitations/implications
The paper shows that blockchain can be utilised as part of a system generating visibility and trust in supply chains. Research directs academic attention to issues that remain to be addressed. The challenges pertaining to the technology itself we believe to be generalisable; those specific to the food industry may not hold elsewhere.

Practical implications
From live case studies, we provide empirical evidence that blockchain provides visibility of exchanges and reliable data in fully digitised supply chains. This provides provenance and guards against counterfeit goods. However, firms will need to work to gain consumer buy-in for the technology following repeated past claims of trustworthiness.

Originality/value
This paper provides primary evidence from blockchain use cases “in the wild”. The exploratory case studies examine application of blockchain for supply chain visibility.
A new mapping outcome method to measure social return on investment: a case study in Peru
Authors: Saenz Cesar Sandro 
Published: May 2020

Purpose
This paper aims to contribute a new way to carry out outcome mapping (OM) for corporate social responsibility (CSR) projects based on three elements: the lifecycle of the CSR project, its stakeholders and sustainability outcomes. To develop this new OM, CSR projects in the mining industry are analyzed to discover their economic, environment and societal impacts.

Design/methodology/approach
A multiple-case study approach is used. Data were collected through direct observations and documents, and complementary attitudinal feedback was also obtained from interviews with community, government and industry leaders.

Findings
Mapping the CSR project lifecycle, stakeholders and sustainability outcomes simultaneously generate a better approximation of the real impact of the projects that are analyzed. Each stage of the lifecycle reveals new sustainability outcomes for each stakeholder.

Originality/value
This paper provides a new approach to OM and therefore provides a new way to assess CSR projects.
Omnivorous ants are less carnivorous and more protein‐limited in exotic plantations
Authors: Tsang Toby P. N. , Guénard Benoit , Bonebrake Timothy C. 
Published: May 2020

Abstract

Diets of species are crucial in determining how they influence food webs and community structures, and how their populations are regulated by different bottom‐up processes. Omnivores are able to adjust their diet flexibly according to environmental conditions, such that their impacts on food webs and communities, and the macronutrients constraining their population, can be plastic. In particular, omnivore diets are known to be influenced by prey availability, which exhibits high spatial and temporal variation.
To examine the plasticity of diet and macronutrient limitation in omnivores, we compared trophic positions, macronutrient preferences and food exploitation rates of omnivorous ants in invertebrate‐rich (secondary forests) and invertebrate‐poor (Lophostemon confertus plantations) habitats. We hypothesized that omnivorous ants would have lower trophic positions, enhanced protein limitation and reduced food exploitation rates in L. confertus plantations relative to secondary forests.
We performed cafeteria experiments to examine changes in macronutrient limitation and food exploitation rates. We also sampled ants and conducted stable isotope analyses to investigate dietary shifts between these habitats.
We found that conspecific ants were less carnivorous and had higher preferences for protein‐rich food in L. confertus plantations compared to secondary forests. However, ant assemblages did not exhibit increased preferences for protein‐rich food in L. confertus plantations. At the species‐level, food exploitation rates varied idiosyncratically between habitats. At the assemblage‐level, food exploitation rates were reduced in L. confertus plantations.
Our results reveal that plantation establishments alter the diet and foraging behaviour of omnivorous ants. Such changes suggest that omnivorous ants in plantations will have reduced top‐down impacts on prey communities but also see an increased importance of protein as a bottom‐up force in constraining omnivore population sizes.
Large‐scale variation in birth timing and synchrony of a large herbivore along the latitudinal and altitudinal gradients
Authors: Peláez Marta , Gaillard Jean‐Michel , Bollmann Kurt , Heurich Marco , Rehnus Maik 
Published: May 2020

Abstract

Hopkins’ Bioclimatic Law predicts geographical patterns in phenological timing by establishing a correspondence between latitudinal and altitudinal gradients. First proposed for key phenological events of plants, such as leaf sprouting or flowering dates, this law has rarely been used to assess the geographical equivalence of key life‐history traits of mammals.

We hypothesize that (H1) parturition dates of European roe deer Capreolus capreolus are delayed and more synchronized at higher latitudes and altitudes, (H2) parturition timing varies along latitudinal and altitudinal gradients in a way that matches the Hopkins’ Bioclimatic Law and (H3) females adjust parturition timing to match the period of high energy demand with peak resource availability.

We used parturition dates of 7,444 European roe deer from Switzerland to assess altitudinal variation in birth timing and synchrony from 288 to 2,366 m a.s.l. We then performed a literature survey to compare altitudinal results with those from different populations along the species’ latitudinal range of distribution. Finally, we performed spatial analysis combining our highly resolved altitudinal data on parturition dates with plant phenology data.

As expected, parturition dates were delayed with increasing latitude and altitude. This delay matched the Bioclimatic Law, as the effect of 1º increase in latitude was similar to 120 m increase in altitude. However, while parturitions were more synchronized with increasing altitude, we did not detect any trend along the latitudinal gradient. Finally, plant phenology explained altitudinal variation in parturition timing better than a linear effect of altitude.

Our findings clearly demonstrate the ability of a large herbivore to match parturition timing with phenological conditions across the altitudinal gradient, even at the smallest spatial scales.
Tobramycin suppresses HUWE1 degradation to control MCL‐1 stability during tumour development
Authors: He Jiabei , Wu Sixian , Li Xiaoliang , Tang Li , Chen Hanxiao , Qin Lang , Xie Jiang , Lu Tao , Xu Wenming 
Published: May 2020

AbstractHUWE1 is an E3 ubiquitin ligase that is involved in cancer cell proliferation by regulating MCL‐1 stability. The HECT domain has been shown to be required for the ubiquitin ligase activity of HUWE1. To identify efficient drugs that impair the activity of HUWE1, and thus decrease MCL‐1 accumulation, we screened 2000 candidate compounds that might suppress HUWE1 activity. To evaluate these 2000 candidates, the HECT domain of HUWE1, which is the catalytic domain responsible for MCL1 ubiquitination, was selected as a conjugation site, and putative binding candidates were filtrated. Tobramycin emerged as one of the compounds that show efficient binding ability with the HECT domain of HUWE1. The surface plasmon resonance (SPR) results validated the specific binding of Tobramycin with the HECT domain. Subsequent analyses demonstrated its potential to inhibit cancer cell proliferation by binding to the HECT domain of HUWE1 and impeding the HUWE1‐mediated ubiquitination of MCL‐1. Consequently, the accumulation of MCL‐1 inhibited the proliferation of tumour cells, while the apoptosis rates were not significantly altered after Tobramycin treatment. In vitro experiments showed that Tobramycin could inhibit cell proliferation by regulating the G2/M transition in cancer cell models, including A549 and HeLaCaco2 cell lines. Our results indicated that Tobramycin could be a potential new probe to develop targeted therapies for the prevention or treatment of HUWE1‐overexpressing cancers.
Hepatic volume changes post‐selective internal radiation therapy with 90Y microspheres
Authors: Ong Frederick , Tibballs Jonathan 
Published: May 2020

AbstractIntroductionTo examine the hepatic volume changes post‐selective internal radiation therapy with 90Y microspheres. This technique has been demonstrated to be a suitable alternative to portal vein embolisation to induce hypertrophy of the future liver remnant (FLR) in patients with malignant disease of the liver preoperatively. The role of both techniques is to decrease postoperative morbidity and increase the numbers of patients eligible for surgical resection. Unlike portal vein embolisation, radioembolisation has the additional benefit of treating liver malignancy and reducing the risk of tumour progression during the hypertrophy period.MethodsA retrospective analysis was conducted of 29 patients from August 2012 to November 2016 that had right liver lobe malignant disease (primary or secondary) and underwent selective internal radiation therapy. Changes in liver volume were measured from CT or MRI before treatment and at 3, 6 and 12 months post‐SIRT.ResultsEighteen patients (62%) had primary liver malignancies (HCC n = 15, cholangiocarcinoma n = 3), and 11 patients (38%) had metastases (colorectal carcinoma n = 10, ampullary carcinoma n = 1). There was a mean increase in the FLR volume relative to baseline of 37.2% at 3 months (n = 25), 42.6% at 6 months (n = 19) and 63.5% at 12 months (n = 12). There was a mean decrease in whole liver volume at 12 months by −13.3%.ConclusionRight liver lobe SIRT induces left liver lobe (FLR) compensatory hypertrophy. This study’s data support the use of SIRT in selected patients with right liver lobe malignancy to undergo SIRT to facilitate liver resection.
Expression profiles of growth‐related genes in two Nile tilapia strains and their crossbred provide insights into introgressive breeding effects
Authors: Herkenhoff M. E. , Ribeiro A. O. , Costa J. M. , Oliveira A. C. , Dias M. A. D. , Reis Neto R. V. , Hilsdorf A. W. S. , Pinhal D. 
Published: May 2020

SummaryThe Nile tilapia (Oreochromis niloticus) is a prominent farmed fish in aquaculture worldwide. Crossbreeding has recently been carried out between the Red‐Stirling and the wt Chitralada strains of Nile tilapia, producing a heterotic hybrid (7/8 Chitralada and 1/8 Red‐Stirling) that combines the superior growth performance of the Chitralada with the reddish coloration of the Red‐Stirling strain. While classical selective breeding and crossbreeding strategies are well known, the molecular mechanisms underlying the phenotypic expression of economically advantageous traits in tilapia remain largely unknown. Molecular investigations have shown that variable expression of growth hormone (gh), insulin‐like growth factors (igf1and2) and somatolactin (smtla) – components of the growth hormone/insulin‐like growth factor (GH/IGF) axis – and myostatin (mstn) genes can affect traits of economic relevance in farmed animals. The aim of this study was to assess and compare the gene expression signature among Chitralada, Red‐Stirling and their backcross hybrid in order to gain insights into the effects of introgressive breeding in modulation of the GH/IGF axis. Gene expression analyses in distinct tissues showed that most genes of the GH/IGF axis were up‐regulated andmstnwas down‐regulated in backcross animals in comparison with Red‐Stirling and Chitralada animals. These gene expression profiles revealed that backcross animals displayed a distinctive expression signature, which attests to the effectiveness of the introgressive breeding technique. Our findings also suggest that the GH/IGF axis andmstngenes might be candidate markers for fish performance and prove useful within genetic improvement programs aimed at the production of superior‐quality tilapia strains using introgressive breeding.
Transforming growth factor‐β1 in intrauterine adhesion
Authors: Abudukeyoumu Ayitila , Li Ming‐Qing , Xie Feng 
Published: May 2020

AbstractIntrauterine adhesion (IUA), led by trauma to the basal layer, can prevent the endometrium from growing, resulting in complications in females, such as infertility and amenorrhea. Transforming growth factor‐β1 (TGF‐β1) plays a crucial role in inducing and promoting the differentiation and proliferation of mesenchymal cells, in the secretion of extracellular matrix‐associated components, and is a major cytokine in initiating and terminating tissue repair downstream of the TGF‐β/Smad signaling pathway. Some evidence supports that TGF‐β1 is closely associated with the occurrence and development of IUA, and is regarded as an early risk factor of disease recurrence. Furthermore, the role of TGF‐β1 has been demonstrated to be potentially regulated by a variety of cytokines, hormones, enzymes, and microRNAs. This review provides an overview of the expression, function, and regulation of TGF‐β1 in IUA, with a brief discussion and perspectives on its future clinical implications on the diagnosis and treatment of IUA.
Impact of antithrombotic therapy on the outcomes with focus on bleeding and thromboembolic events in patients undergoing pancreticoduodenectomy
Authors: Komokata Teruo , Aryal Bibek , Tada Nobuhiro , Kaieda Mamoru , Nuruki Kensuke 
Published: May 2020

AbstractBackgroundWe investigated perioperative outcomes of pancreaticoduodenectomy (PD) in patients receiving antithrombotic therapy (ATT) with a focus on the incidence of perioperative bleeding and thromboembolic complications.MethodsA total of 77 patients who underwent PD at our institution between 2013 and 2019 were retrospectively reviewed. Clinical findings and surgical outcomes including bleeding and thromboembolic complications were compared in patients with or without ATT. Interruption of ATT and perioperative heparin bridging were based on our hospital protocol.ResultsAmong ATT (30) and non‐ATT (47) groups, ATT group had a significantly higher age and history of cardiocerebrovascular diseases. No significant difference was observed in intraoperative and post‐pancreatectomy haemorrhage (PPH) between the groups. ATT group was associated with a significantly higher rate of post‐operative complications, Clavien–Dindo classification ≥II and thromboembolic events. Operative mortality in ATT and non‐ATT groups was 2 (6.7%) and 1 (2.1%), respectively. There was no significant association between ATT and excessive intraoperative blood loss (≥1000 mL), PPH (≥grade B) and thromboembolic complications (Clavien–Dindo classification ≥II).ConclusionIn patients with ATT, PD is a feasible procedure with no major impact on intraoperative bleeding or PPH.