bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weekly Carboplatin and Paclitaxel: A Retrospective Comparison with the Three-Weekly Schedule in First-Line Treatment of Ovarian Cancer
Authors: Safra Tamar , Waissengrin Barliz , Levy Talya , Leidner Ellie , Merose Rotem , Matceyevsky Diana , Grisaru Dan , Laskov Ido , Mishaan Nadav , Shayzaf Rotem , Wolf Ido 
Published: July 2020

Abstract

Background
Conventional first-line combination therapy for ovarian cancer comprises 6 cycles of adjuvant or neoadjuvant carboplatin (AUC5-6) with paclitaxel (175 mg/m2) every 3 weeks (PC-3W). Weekly scheduling of paclitaxel may maximize its antiangiogenic effect and reduce adverse effects. We compared the efficacy and safety of PC-3W with a modified protocol of weekly paclitaxel 80 mg/m2 and weekly carboplatin AUC2 administered on days 1, 8, and 15 in a 28-day cycle (i.e., with 1 week off-treatment [PC-W]).

Materials and Methods
Medical records of consecutive patients treated between 2000 and 2018 were reviewed; 707 patients were analyzed for demographic and clinical characteristics, effectiveness and toxicity.

Results
PC-3W was administered to 402 patients (median age, 60.5 years) and PC-W to 305 patients (median age, 62.5 years). Most patients (91.4%) were diagnosed at stage III–IV. Notwithstanding a higher proportion of residual disease and older patients in the PC-W group, median progression-free survival was 21.4 months and 13.2 months for PC-W and PC-3W, respectively; median overall survival was 75.2 and 54.0 months for PC-W and PC-3W, respectively. Cox proportional hazards model indicated improved survival for patients treated with PC-W (hazard ratio, 0.54). Similar results were observed for older patients diagnosed at ≥75 years. PC-W demonstrated a better safety profile, with lower incidence of neuropathy, neutropenia, and alopecia.

Conclusion
PC-W is as active and better tolerated than the standard PC-3W regimen. PC-W may serve as an alternative option for elderly or frail patients.

Implications for Practice
Weekly scheduling of paclitaxel 80 mg/m2 and carboplatin AUC2, administered on days 1, 8, and 15 in a 28-day cycle (PC-W) for first-line therapy for advanced ovarian cancer, is as active and better tolerated than the standard regimen of carboplatin and paclitaxel (175 mg/m2) every 3 weeks (PC-3W). It is possible that the weekly holiday on day 21 in the PC-W regimen may ensure better completion rates (which may result in treatment delays for toxicity in PC-3W). The results of this retrospective analysis highlight the weekly regimen as a valid treatment option, especially for elderly patients and those with significant comorbidities.
MENINGKATKAN KECERDASAN KINESTETIK ANAK MELALUI GERAK TARI HUDOQ DAYAK BAHAU DI TAMAN KANAK –KANAK NEGERI PEMBINA 2 MUARA WAHAU
Authors: Yanti Nila Sari , Hanita Hanita 
Published: July 2020

A child is defined as an individual who entering adult phase. When they are getting older, they must master basic competence. In this stage, all potentials they have are developed, including kinesthetic intelligence. In case of students in Pembina 2 Kindergarten Muara Wahau, they showed low kinesthetic intelligence since they looked bored, and did not focus on lesson when doing sport exercise. Kinesthetic intelligence in early age students can be stimulated through dance, since, basically, they like music and dance. Dancing demands balance, body movement coordination, strength, and muscle flexibility. This study applied classroom action research. The research subjects were students of Group B Pembina 2 Kindergarten Muara Wahau. Meanwhile, the aspects being analyzed were students’ ability in imitating the movement fast, remembering dance movement, coordinating movement and rhythm, and dancing without help. The data were collected through documentation and direct observation toward the teacher and the students, observing teacher conducting teaching and learning process by implementing Hudoq Dayak Bahau dance. The result shows that, in pre-cycle, the average score was 17,3%, meaning that students had not developed yet. At the first cycle, students achieved 40,98%, meaning that students started to develop. The percentage increased into 97,7% at second cycle, meaning that students developed very well. Therefore, it can be concluded that teaching with Hudoq dayak bahau dance is effective to improve kinesthetic intelligence, especially for students of group B in Pembina 2 Kindergarten Muara Wahau. It is expected that teachers can apply this method to improve students’ kinesthetic intelligence.
Efecto de la infección crónica del tracto urinario en el peristaltismo ureteral
Authors: Granada Luis , Kidd James , Idrias Farouk , Swenson Orvar 
Published: July 2020

En el problema de la infección del tracto urinario se le ha puesto atención, solamente, al punto de vista local de la destrucción del tejido renal, y muy poco interés se le ha dado a los efectos nocivos de la infección sobre el segmento de transporte, del sistema urinario.
How to Strengthen the Ideological and Political Education of Nurse in Humanistic Accomplishment
Authors: Li Yin 
Published: July 2020

<p>In order to avoid disputes between doctors and patients, improve the quality of nursing, the professional quality of nurses in society and hospitals is demanding higher and higher. This professional quality refers not only to nursing skills, but also to humanistic cultivation and ideological and political qualities. This article will specifically discuss the strategy of ideological and political education in humanistic cultivation of nurse, hoping to train better nurses.</p>
The Experimental Teaching Reform and Exploration of Pharmaceutical Chemistry in Biopharmaceutical Major
Authors: Xia Wandong 
Published: July 2020

<p>Pharmaceutical chemistry is an important course in biopharmaceutical major. The subject knowledge permeates many subjects and has a strong theoretical and guiding function. However, there are still a lot of problems in the pharmaceutical chemistry experiment course and the development is not perfect, which needs to be timely reformed and innovated. This paper mainly discusses the reform of experimental teaching of pharmaceutical chemistry in biopharmaceutical major, analyzes the current situation of experimental teaching of pharmaceutical chemistry, finds out the problems and gives solutions, and proposes the corresponding reform measures. This paper explores active and effective teaching methods from the aspects of teaching modes, the laboratory, experimental materials and teaching methods, so as to improve the experimental teaching of pharmaceutical chemistry of biopharmaceutical major, improve the teaching quality and promote the cultivation of students' comprehensive ability.</p>
The Enlightenment of International College Education Open Courses on China's College Courses Construction
Authors: Lv Jing 
Published: July 2020

<p>This article analyzes the problems existing in China’s colleges in drawing on the open courses of international college education, through the summary of relevant experiences to promote the development of China’s college education courses. We should build the college education courses system with Chinese characteristics to satisfy people's expectations for college education.</p>
Desafíos de la investigación en educación Matemática
Authors: Jiménez Alfonso 
Published: July 2020

En esta época de cambio tan acelerado, en la cual la velocidad de producción de conocimiento es tal, que es imposible dar cuenta siquiera de cualquier reducida área de conocimiento, incluso para cualquier especialista, la investigación y la reflexión permanentes sobre la mejor forma de entender la complejidad del aula de clase, de la escuela y de la sociedad son necesidades absolutas. La investigación en educación matemática enfrenta serios desafíos para entender la poderosa influencia de la matemática en una sociedad tecnologizada y en una cultura dependiente de esta (Borba &amp; Skovsmose, 1997, 2001), para que la investigación no continúe haciendo más de lo mismo.
Determination of late spring frost effects on Monroe peach cultivars in different training systems, planting intervals and height of flower
Authors: ÇETİNBAŞ Melike , SARISU Hasan Cumhur , BUTAR Sinan 
Published: July 2020

Objective: Main purpose of this study is to determine whether the rates of frost damages on pistils caused by the lower temperature varies between different planting distances and the different training systems with the heights of the peach trees.
Material and Methods: The flowers of Monroe/GF 677 peach trees grown in different training systems and planting distances, in the pink bud period, on the 1nd day after the frost that occurred in the period, morning of April 1, hours 5:00 AM-7:00 AM, temperatures -0.33 to -1.23° C, 3 replicates with 100 flowers in each replicate were collected from 4 sides of Slender Spindle, Y-Trellis, Central Leader and Open Vase trees planted with different planting distances from both 1m and 2m height.
Results: The frost damage rates have been obtained as 5.05% for Slender Spindle training system and 2.05% for Y-Trellis training system in the support systems. In unsupported systems, peach cultivation with the Central Leader training system caused less frost damage.
Conclusion: Y-Trellis cultivation system in supported systems and Central Leader in unsupported systems for peach cultivation resulted less frost damage and therefore it was suggested that they were a better systems in terms of productivity.
PLURALISME AGAMA: STUDI TENTANG MAKNA DAN POLA KOMUNIKASI ANTAR UMAT ISLAM, HINDU DAN BUDHA DI PULAU LOMBOK. KOTA MATARAM
Authors: Saputra Hasyim Edi Rianto , Tayib Muhtar 
Published: July 2020

Isu pluralisme bukan lagi sebagai wacana yang diperdebatkan oleh para intelektual yangmasih berkisar pada hal-hal yang bersifat teoritis- spekulatif tetapi sudah merambah pada hal yang lebih kongkrit yaitu praktis-pragmatis. Di Indonesia sendiri istilah pluralisme agama menjadi marak diperbincangkan setelah di usung oleh Nurcholis Madjid, Mukti Ali, Djohan Efendi. Dan pada tahun terakhir ini dilanjutkan oleh generasi berikutnya. Budhy Munawar Rahman dengan Paramadinanya, Ulil Abshar Abdalla dan kawan-kawan dengan Jaringan Islam Liberalnya (JIL). Terlebih lagi di pulau lombok yang terletak di provinsi NTB (Nusa Tenggara Barat), Degan asas skularisme ini masyarakat Sasak Lombok mampu menciptakan keharmonisan dan menciptakan pluralisme agama dan budaya menjadi indah. Sehingga tetap terjalin komunikasi antar umat beragama, adapun strategi yang digunakan yang masyarakat sasak menyebutnya “Panca Budaya Pluralis” antara lain: 1) Lewat budaya saling ajinin; 2) Lewat budaya saling pesilaq; 3) Lewat budaya saling pelayarin; 4) Lewat budaya saling ayowin.
Safety and Immunogenicity of the Quadrivalent Human Papillomavirus Vaccine in Patients with Juvenile Dermatomyositis: A Real-World Multicentre Study
Authors: Grein Ingrid Herta Rotstein , Pinto Natalia Balera Ferreira , Groot Noortje , Martins Camila Bertini , Lobo Aline , Aikawa Nadia Emi , Barbosa Cassia , Terreri Maria Teresa , Fraga Aline Coelho Moreira da , de Oliveira Sheila Knupp Feitosa , Sztajnbok Flavio , Marques Luciana B. Paim , Islabão Aline Garcia , Appenzeller Simone , Bica Blanca , Sato Juliana de Oliveira , Magalhães Claudia Saad , Ferriani Virginia , Pasmans Hella , Schepp Rutger , Klis Fiona van der , de Roock Sytze , Wulffraat Nico , Pileggi Gecilmara Salviato 
Published: July 2020

Abstract
Background: Concerns about the safety and efficacy of vaccines in patients with autoimmune diseases (AID) have led to contradictions and low vaccination coverage in this population, who are at a higher risk of infections, including by human papillomavirus (HPV). Although HPV vaccines have been recommended for immunocompromised patients, there is still a lack of data to support its use for AID patients, such as juvenile dermatomyositis (JDM) patients. The aim of this study was to assess the safety and immunogenicity of the quadrivalent HPV (qHPV) vaccine in a cohort of JDM patients.Methods: JDM patients aged from 9-20 years and healthy controls (HC) were enrolled to receive a 3-dose schedule of qHPV vaccine from March/2014 to March/2016. Study visits were performed before the first dose, one month after the second and third doses, and six months after the third dose. Participants completed a diary of possible adverse events for 14 days following each dose of vaccination (AEFV). Disease activity and current therapy were analyzed at each visit for JDM patients. In addition, serum samples from all participants were collected to test antibody concentrations against HPV16 and 18 at each visit. Participant recruitment was conducted in ten Brazilian centres. From 47 eligible JDM patients and 41 HC, 42 and 35, respectively, completed the 3-dose schedule of the vaccine, given that five JDM patients and two HC had received doses prior to their inclusion in the study.Results: The AEFVs presented by the participants were mild and in general did not differ between JDM and HC groups. No severe AEFVs were related to the vaccination. Disease activity was stable, or even improved during the follow-up. One month after the third dose of the vaccine the JDM group presented seropositivity of 100% for HPV16 and 97% for HPV18, similarly to the HC group, who presented 100% for both serotypes (p = 1.000). Six months after the third dose the seropositivity for the patient group was 94% for both HPV types.Conclusions: The HPV vaccination in this cohort of JDM patients was safe and immunogenic. Since the seropositivity against HPV16 and 18 was very high after the 3-dose schedule, this regimen should be recommended for JDM patients.Trial registration: Brazilian Clinical Trials Registry, number: RBR-9ypbtf, link: http://www.ensaiosclinicos.gov.br/rg/RBR-9ypbtf/. Registered 20 March 2018 – Retrospectively registered.
Comparison of IOL Power Calculated by Preoperative Biometry versus Intraoperative Wavefront Aberrometry in Thai Cataract Patients.
Authors: Khambhiphant Bharkbhum , Thanyaporn Sribenjapanon 
Published: July 2020

Abstract
Background: To find agreement between the calculated intraocular lens (IOL) power from using the SRK/T based preoperative biometry and the intraoperative wavefront aberrometry (ORA®) in Thai cataract patients, and to compare the accuracy of each method with the postoperative refraction results.Methods: Eyes that underwent cataract surgery with monofocal or multifocal IOL implantation were enrolled in this prospective study. All eye biometry was measured preoperatively and the ORA intraoperatively. The SRK/T suggested IOL from the preoperative biometry was chosen in all cases. The suggested power and the estimated refraction (EST) from both devices were collected. Bland Altman analysis was used to find the agreement between them. The predicted EST of implanted IOL from both devices were compared with the one-month postoperative SE. Results: The study comprised 97 eyes (79 patients). Of these, 38 eyes (39.2%) had the same suggested IOL power, 36 eyes (37.1%) were within ±0.5D, 20 eyes (20.6%) were within ±1.0D and 3 eyes were beyond ±1.0D. Bland-Altman analysis found the mean difference between IOL power calculated from both devices was 0.39 with LoA of -0.54 to 1.31. The correlation was 98.50% (95%CI 98%- 99.10%). In the same suggested IOL power group, the median difference of EST by preoperative biometry and ORA compared with one-month postoperative SE were -0.08 (95%CI: -0.08, 1.11), and -0.14 (95%CI: -0.88, 1.2), respectively. Conclusions:The ORA and preoperative biometry results were in concordance with each other. The result of preoperative biometry was more accurate than ORA in this study. Trial Registration: The thai clinical trial registration number: TCTR20171005001Registration Date: October 3rd, 2017First Enrollment: November 10th, 2017
Knowledge, Attitude and Practice of Emergency Contraceptive Pills among Community Pharmacy Practitioners working in Kathmandu Valley: A cross-sectional study
Authors: Shakya Sujyoti , shrestha sweta , Shrestha Rojeena Koju , Giri Usha , Shrestha Sunil 
Published: July 2020

Abstract
Background Unintended pregnancy occurs due to incorrect or inconsistent use of a contraception method. Such pregnancies can create an economic burden on the family, society and nation as a whole. Unintended pregnancy is the underlying cause of abortion which can also result in infertility and maternal death. Adequate knowledge of emergency contraceptive pills (ECPs) and positive attitude among the community pharmacy practitioners (CPPs) is a prerequisite for timely access of ECP, thus ultimately abating the incidence of unintended pregnancies. This study intended to explore the knowledge, attitude and practice of CPPs toward ECPs in Kathmandu valley. Methods Cross-sectional study conducted in community pharmacies located in three districts of Kathmandu valley. A convenience sampling method was employed to interview CPPs in 227 community pharmacies using a validated questionnaire. Questionnaire assessed the demographic characteristics, knowledge, attitude and dispensing practice of the CPPs. Data were subjected to descriptive and inferential analysis using SPSS 18 (SPSS Inc., Chicago, IL, USA). Results Approximately 74.9% of respondents had a good practice on dispensing ECPs, and 70% of them counselled all the users. A significant association (p-value<0.05) was obtained between the dispensing practice of respondents and their knowledge level. ECP related knowledge was higher among the age group 40-49 years, BPharm degree holders with experience above ten years and community pharmacies located inside the city and in the Kathmandu district. After adjusting the possible confounder variables, age, degree and district of pharmacy were significantly associated with knowledge. Similarly, respondents' practice towards ECP was higher among the age group 40-49 years with experience above ten years and community pharmacies located inside the city and in the Kathmandu district. Adjusted for other variables, only community pharmacies located at Kathmandu district was significantly associated with the practice. Conclusion CPPs lacked specific important information on ECP and opined against its' availability as an OTC drug, despite good overall knowledge and positive attitude. Many thought that ECP without prescription would increase promiscuity towards sexual behaviour and result in unsafe sex along with its' repeated use. Hence, training and proper counselling strategies should be afoot to refine the delivery of service by CPPs.
CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK
Authors: Xue Jimeng , Xu Liling , Zhu Huaqun , Bai Mingxin , Li Xin , Zhao Zhen , Zhong Hua , Cheng Gong , Li Xue , Hu Fanlei , Su Yin 
Published: July 2020

Abstract
Background: Monocytes as precursors of osteoclasts in rheumatoid arthritis (RA) were well demonstrated, while monocyte subsets in osteoclast formation were still controversial. Tyro3 tyrosine kinase (Tyro3TK) is a member of the receptor tyrosine kinase family involved in immune homeostasis, the role of which in osteoclast differentiation was reported recently. This study aimed to compare the osteoclastic capacity of CD14+CD16+ and CD14+CD16- monocytes in RA and determine the potential involvement of Tyro3TK in their osteoclastogenesis.Methods: Osteoclasts were induced in CD14+CD16+ and CD14+CD16- monocyte subsets isolated from healthy control (HC) and RA patients in vitro and evaluated by tartrate-resistant acid phosphatase (TRAP) staining. Then, the expression of Tyro3TK on CD14+CD16+ and CD14+CD16- monocyte subsets in peripheral blood of RA, osteoarthritis (OA), and HC were evaluated by flow cytometry and qPCR, and their correlation with RA patient clinical and immunological features were analyzed. The role of Tyro3TK on CD14+CD16- monocytes in RA patient osteoclastogenesis was further investigated by osteoclast differentiation assay with Tyro3TK blockade.Results: The results revealed that CD14+CD16- monocytes were the main source of osteoclasts. The expression of Tyro3TK on CD14+CD16- monocytes was significantly upregulated in RA patients compared with HC and OA patients, and positively correlated with the disease manifestations, such as IgM level, tender joint count and the disease activity score. Moreover, anti-Tyro3TK antibody could dose-dependently inhibited Gas6-mediated osteoclast differentiation in CD14+CD16- monocytes.Conclusions: These findings indicate that elevated Tyro3TK on CD14+CD16- monocytes serves as a critical signal for osteoclast differentiation in RA.
Thinprep® test versus conventional smear for the detection of pancreatic neoplasms after percutaneous ultrasound-guided fine-needle aspiration biopsy
Authors: Tan Li , Zhou Guili , Gui Yang , Meng Zhilan , Chang Xiaoyan , Zhang Jing , Zhou Tongtong , Chen Xueqi , Xiao Mengsu , Zhang Qing , Zhong Guangxi , Lv Ke , Jiang Yuxin 
Published: July 2020

Abstract
Background

Few studies have defined the diagnostic value of ThinPrep pap test (a liquid-based cytology) for pancreatic samples obtained by percutaneous fine-needle aspiration (FNA). This study aimed to compare the efficacy of ThinPrep cytologic test (TCT) in screening pancreatic neoplasms to the conventional smear (CS), especially in the absence of rapid on-site evaluation (ROSE).
Methods

The study evaluated 78 patients with suspected pancreatic tumors who underwent percutaneous ultrasound-guided fine-needle aspiration (US-FNA) combined with CS and TCT. Final disease diagnosis was based on biopsy, surgery, or clinical progress.
Results

The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of TCT were 95.8%, 100%, 96.1%, 100%, 62.5%, whereas the values for CS were 90.1%, 100%, 90.8%, 100%, 41.7%, respectively. The combination of CS and TCT recorded 98.6%, 100%, 98.7%, 100%, 83.3%, respectively, for the parameters evaluated. None of the participants recorded serious complications.
Conclusions

This study shows that TCT is a more reliable tool in the detection of pancreatic neoplasms, especially for percutaneous US-FNA samples. Whereas TCT may be used as an alternative to CS in the absence of ROSE, the use of both methods in the screening process yields better results.
Competencies of Health Educators for Sports Injury Prevention
Authors: Uspuriene Aiste Barbora , Simanavičius Matas 
Published: July 2020

According to the analysis of literature, it can be stated in, that there is a lower risk of experiencing sports injury during training, working with such health educators who has higher education in sports science. It is also can be stated that there are few studies which would determine the education of health educators, the quality of training and sports injuries suffered by clients and their frequency during the conducted trainings (Waryasz, Daniels, Gil, Suric, & Eberson, 2016). Research aim – to determine competencies of health educators for sports injury prevention.