bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro
Authors: Liu Chun-Yu , Wang Min , Yu Hong-Min , Han Fang-Xuan , Wu Qiong-Shi , Cai Xing-Jun , Kurihara Hiroshi , Chen Yong-Xing , Li Yi-Fang , He Rong-Rong 
Published: May 2020

Abstract
A critical pathogenic factor in the development of lethal liver failure is cell death induced by the accumulation of lipid reactive oxygen species. In this study, we discovered and illuminated a new mechanism that led to alcoholic liver disease via ferroptosis, an iron-dependent regulated cell death. Study in vitro showed that both necroptosis inhibitor and ferroptosis inhibitors performed significantly protective effect on alcohol-induced cell death, while apoptosis inhibitor and autophagy inhibitor had no such effect. Our data also indicated that alcohol caused the accumulation of lipid peroxides and the mRNA expression of prostaglandin-endoperoxide synthase 2, reduced the protein expression of the specific light-chain subunit of the cystine/glutamate antiporter and glutathione peroxidase 4. Importantly, ferrostatin-1 significantly ameliorated liver injury that was induced by overdosed alcohol both in vitro and in vivo. These findings highlight that targeting ferroptosis serves as a hepatoprotective strategy for alcoholic liver disease treatment.
Coldzyme® Mouth Spray reduces duration of upper respiratory tract infection symptoms in endurance athletes under free living conditions
Authors: Davison Glen , Perkins Eleanor , Jones Arwel W. , Swart Gabriella M. , Jenkins Alex R. , Robinson Hayley , Dargan Kimberly 
Published: May 2020

AbstractUpper respiratory tract infection (URTI) can compromise athlete preparation and performance, so countermeasures are desirable. The aim of this study was to assess the effects of ColdZyme® Mouth Spray (ColdZyme) on self‐reported upper respiratory tract infection in competitive endurance athletes under free‐living conditions. One hundred and twenty‐three endurance‐trained, competitive athletes (recruited across 4 sites in England, UK) were randomised to control (no treatment, n = 61) or ColdZyme (n = 62) for a 3‐month study period (between December 2017 and March 2018; or December 2018 and April 2019). They recorded daily training and illness symptoms (Jackson common cold questionnaire) during the study period. A total of 130 illness episodes were reported during the study with no difference in incidence between groups (episodes per person: 1.1 ± 0.9 Control, 1.0 ± 0.8 ColdZyme, P = 0.290). Episode duration was significantly shorter in ColdZyme compared to Control: Control 10.4 ± 8.5 days vs. ColdZyme 7.7 ± 4.0 days, P = 0.016). Further analysis to compare episodes with poor vs. good compliance with ColdZyme instructions for use (IFU) within the ColdZyme group showed a greater reduction in duration of URTI when compliance was good (9.3 ± 4.5 days in ColdZyme poor IFU compliance vs. 6.9 ± 3.5 days in ColdZyme good IFU compliance, P = 0.040). ColdZyme may be an effective countermeasure to reduce URTI duration, which was significantly lower (by 26‐34%) in the ColdZyme treatment group (with no influence on incidence). This may have implications for athlete performance.
Retracted: Preparation and characterization of borosilicate-bioglass-incorporated sodium alginate composite wound dressing for accelerated full-thickness skin wound healing
Authors: Wu Chunxuan , Zhang Zhongjie , Zhou Kui , Chen Weigao , Tao Jun , Li Chen , Xin Hongbo , Song Yulin , Ai Fanrong 
Published: May 2020

Abstract
Full-thickness skin injury is a serious and intractable clinical problem. Wound dressing is urgently needed to treat serious skin defects or induce skin reconstruction. For the first time, we demonstrated a borosilicate bioglass (BBG)-incorporated sodium alginate (SA) wound dressing by a simple and effective technique for accelerated wound healing. The physical and chemical properties, in vitro and in vivo properties of SA-BBG composite wound dressing have been investigated. The results show that the SA-BBG composite dressing possesses good water absorption performance. The boron and silicon ions in BBG can maintain stable and sustained release. Most importantly, the SA-BBG composite wound dressing shows outstanding wound healing ability in full-thickness skin defects in rats. The wounds treated with SA-BBG composite dressing groups had almost closed at day 15. When the ratio of sodium alginate to bioglass in the sponge is 3:1, the wound healing effect is the best. In conclusion, the SA-BBG composite dressing shows great potential for application in skin wound healing and SA3BBG works best.
Vulnerability of vegetation activities to drought in Central Asia
Authors: Deng Haoyu , Yin Yunhe , Han Xiang 
Published: May 2020

Abstract
Central Asia (CA) is a continental region that is sensitive to water conditions. Hence, drought has one of the primary effects on the vegetation activities in CA and could vary with climate change. However, it is still unclear how the drought vulnerability of vegetation differs among vegetation types and varies with drought scales in CA. Therefore, this paper studied the drought vulnerability of vegetation in CA from 1982–2015. Droughts were detected by using the standardized precipitation evapotranspiration index (SPEI), and the vegetation activities were represented by the Normalized Difference Vegetation Index (NDVI). Only the areas with no change in vegetation types were analyzed, in order to avoid interference with changes in land use. Results showed that both the duration and intensity of droughts were higher in the central, southwestern, and northeastern CA. The growing season (April–October) NDVI decreased by −0.0095 ± 0.0065 per decade in response to drying trends of 0.21 ± 0.22 unit aridity index per decade in these drought-concentrated regions. Forests and savannas/woody savannas were more vulnerable to drought from July–September, and their vulnerabilities were higher to droughts with longer time scales. Shrublands and grasslands were more vulnerable to drought from April–May and May–September, respectively, and the vulnerabilities during these months were higher for the droughts at 6–12 months scales. Twelve months was the optimal (most vulnerable) drought scale for the shrublands and grasslands and the secondary drought scale for the savannas/woody savannas. Further analysis of the vulnerability of vegetation to 12 months drought found that it generally increased with the increase of the drought magnitude (duration or intensity) to some peak values and then decreased. However, the vulnerability of forests and savannas/woody savannas increased with the drought intensity. Results would help for the drought risk assessment of vegetation in CA.
Increased nitrous oxide emissions from intertidal soil receiving wastewater from dredging shrimp pond sediments
Authors: Chen Guangcheng , Chen Jiahui , Ou Danyun , Tam Nora F Y , Chen Shunyang , Zhang Qinghua , Chen Bin , Ye Yong 
Published: May 2020

Abstract
The quantities of greenhouse gas emissions and the activity of functional microbes in coastal soils receiving nutrient-rich wastewaters from mariculture activities have seldom been reported. We investigated the effects of wastewater discharge resulting from dredging shrimp pond sediment on the soil fluxes of methane (CH4) and nitrous oxide (N2O) in intertidal areas and on the functional microorganisms and physio-chemical characteristics of soil. The temporal variations in gas fluxes and soil characteristics following wastewater discharge were also evaluated with the tidal regime on the day of discharge taken into account. The results showed that wastewater discharge immediately resulted in higher levels of ammonia (NH4
+-N) deposited and N2O emissions from the soil at the discharge site than at the non-discharge site, while the CH4 flux was not affected. The increase in N2O flux lasted for a longer time when the discharge was performed during a neap tide day than when it was performed during a spring tide day. Wastewater discharge also increased the abundance of ammonia-oxidizing bacterial (AOB) amoA genes and nosZ genes in soil rather than increasing the abundance of narG and nirK genes. The pattern of temporal variations between the N2O flux and soil NH4
+–N content was similar to that between the flux and the AOB-amoA gene abundance, suggesting that bacterial nitrification was important for N2O production in soil receiving the dredging wastewater. The results suggest that the wastewater discharge impacts nitrogen metabolism processes and causes a significant N2O emission problem; therefore, pollutant management is essential in shrimp culturing activities to reduce greenhouse gas emissions into the atmosphere.
On the role of rainfall deficits and cropping choices in loss of agricultural yield in Marathwada, India
Authors: Zachariah Mariam , Mondal Arpita , Das Mainak , AchutaRao Krishna Mirle , Ghosh Subimal 
Published: May 2020

AbstractCrop loss and ensuing social crises can be detrimental for the agriculture-driven economy of India. Though some studies identify country-wide increasing temperatures as the dominant factor for crop loss, the agro-climatic diversity within the country necessitates an understanding of the influence of climate variability on yields at regional scales. We report a complex interplay among rainfall, temperature and cropping choices, with a focus on the drought-prone Marathwada region in Maharashtra. Our analysis based on observations, as well as statistical and process-based modelling experiments, and temperature projections of 1.5 °C and 2 °C warmer worlds show that for the two major cropping seasons, rainfall deficit is the primary cause of crop failure, as compared to rising temperatures. The gradual shift from drought-resilient food crops, such as sorghum and pearl-millet to water-intensive cash crops such as sugarcane in recent years, is seemingly responsible for aggravating this crisis. Our findings warrant strategies promoting drought-resilient food crops, that will be useful, not only for mitigating the immediate agrarian crisis, but also for curbing impending threats to food security in the region under future climate change.
Climatic Zoning of SST in the East China Sea and Adjacent Seas from 1981 to 2010
Authors: Meng Xiangchun , Kang Jiancheng , Wang Xin 
Published: May 2020

Abstract
In this study, the data of sea surface temperature (SST) and current for 1981 to 2010 from the SODA_2.2.4 were used to analyze the climatic zoning characteristics of SST in the East China Sea and adjacent sea areas, and the relationship between SST and relevant factors, to provide a reference for further research on long-term climate change. The results show that : (1) Under the combined action of sea-land distribution, latitude and ocean current, the study area can be divided into three climatic zones: the continental shelf area of the East China Sea, the Kuroshio area of the East China Sea and the Northwest Pacific Ocean. SST from northwest to southeast presents a low - high - second high distribution pattern. (2) Due to the influence of the change of direct point of the sun, the highest SST in the low and high latitudes is 1 month apart, which is July and August respectively. In general, the isotherm in the study area is dense in February. The average SST in the whole region was the lowest, about 19.9°C. The temperature difference between North and South is large, about 17°C. August isotherms are sparse; the average SST in the whole area is the highest, about 28.5°C; the temperature difference between north and south is small, about 6°C. (3) The annual temperature difference of the surface waters of the whole study area is related to latitude. Compared with the latitude, the annual temperature difference in the continental shelf area is the largest, and the Kuroshio area is the smallest. According to coefficient of variation of monthly SST, the annual variation of SST decreases from northwest to southeast. (4) SST rises fastest in May, June and July; and declines fastest in December and January. High-latitude sea areas and near-shore sea areas have rapider and larger changes in SST, and the Kuroshio affected area has slower and smaller changes.
Research on the Technology of a Multifunctional Intelligent Rural Work Machine
Authors: Liu Jilu , Wang Chunfang , Tan Weibing 
Published: May 2020

Abstract
Based on a full study of the agricultural mechanization market, a three-step strategic development plan for the intelligent rural management machine is formulated. The first generation of our products is now on the market. This rural business machine does not require manual driving, but still requires manual remote field remote control. The research of the project is centered on a cruise intelligent rural operation machine with satellite positioning system. This type of intelligent rural work machine equipped with a navigation system uses GPS satellite navigation, so the positioning accuracy can reach 5 cm. Therefore, we only need to set the work area, and then the machine’s measurement and control system can automatically plan the work route. We change different agricultural implements, such as: harvesters, tractors, pesticide sprayers, etc. After the navigation system is installed on these agricultural implements, the main agricultural operations such as planting, spraying, and harvesting of farmers can be completed automatically, which saves labor costs and improves operation efficiency. This rural work machine truly realizes the precision and intelligence of work.
Combination use of gravimetry, CSAMT and SOTEM methods in geophysical prospection of a polymetallic silver-copper deposit: Case studies in the Inner Mongolia, China
Authors: Huang Lishan , Zeng Youqiang , Liu Wentao , Jing Rongzhong 
Published: May 2020

Abstract
Geophysical methods, which use physical properties to reveal the structure of the underground spaces, have been widely applied in geological exploration. However, a single geophysical approach only reflects the distribution of a kind of physical property and therefore has its limitations. To improve the reliability of geophysical methods in actual geological exploration, in this paper, we are trying to combine the use of a variety of geophysical exploration methods, such as gravity, control source audio magnetotelluric method (CSATMT) and electrical source short offset transient electromagnetic method (SOTEM), to a specific metal in Inner Mongolia. Firstly, the gravimetry method is applied to figure out the anomalous area, and then the CSAMT method is adopted to probe the deep electrical distribution. Finally, the SOTEM method is applied for further auxiliary verification. Results show that the underground structure is well revealed by combing the use of these methods. This paper can be used as a reference for the exploration of concealed ore bodies in polymetallic ore deposits. To use a combination of methods to measure. In the geological exploration of a polymetallic silver-copper mine in Inner Mongolia, a variety of geophysical exploration methods such as gravity measurement, controllable source audio magnetotelluric measurement and electrical source short offset transient electromagnetic method were combined, and geological data were combined. The better exploration results provide reference for the layout of the drilling location of the drilling project, and provide assistance for the prospecting breakthrough of the concealed ore body in the polymetallic mining area.
Time Determination of Gas Extraction in Coal Seam Drilling
Authors: Hong Ding , Dong Wang 
Published: May 2020

Abstract
In order to determine the time of the gas extraction of the solid unstable coal seam, based on the characteristics of the change of gas concentration under the condition of continuous extraction of high negative pressure, the drilling gas parameters were tested on the spot and the gas concentration attenuation curve was drawn, and the law of attenuation of the drilling gas concentration was analyzed comprehensively using gas flow theory and geomechanics-related theory. The results show that the interval between the detection and drainage is 0 to 60d, the time of the extraction is 3d, the time of extraction is 60 to 120d, the time of the water testing interval is 7d, the extraction time is 120 to 180d, the time of the water testing interval is 15d, and the extraction time is 180 to 300d. The interval between the measurement of the flow is 30d.
Dynamic Range Expansion Method of Three-component HTc SQUIDs Magnetometer
Authors: Gong X W , Guo J Y , Du J Q , Teng D , Wang Y 
Published: May 2020

Abstract
In view of the small dynamic range of the three-component high-temperature superconducting quantum interference device (HTc SQUID) magnetometer and it is easy to exceed the measurement range when working in the field without magnetic shielding environment. A dynamic range expansion method based on step compensation is proposed. By setting a magnetic compensation coil on each axis of the three-component HTc SQUIDs magnetometer probe, a current is passed to generate a magnetic field opposite to the direction of the external magnetic field to offset most of the magnetic field to be measured. The measured values are calculated and processed to obtain the magnetic field value to be measured. The test results show that the method can greatly improve the dynamic range without reducing the sensitivity of the magnetometer, which can work stably in a non-magnetic shielding environment and meet the requirements of field geophysical magnetic exploration.
Linear Analysis of the Correlation Between Industrial Development and Foreign Trade Development in Guangdong Province—Based on Time Series Data from 2005 to 2018
Authors: Zhong Jiayi 
Published: May 2020

Abstract
As a developed province along the eastern coast of China, Guangdong Province has a close relationship between industrial development and foreign trade. Based on the 2005-2018 time series data, the relevant principles and methods such as least squares method and elasticity theory were used to conduct an empirical analysis of the correlation between Guangdong’s industrial development and foreign trade. The research found that compared with the tertiary industry, the secondary industry is more closely related to foreign trade. However, the tertiary industry is more sensitive to changes in foreign trade. Based on the quantitative measurement of the correlation between industrial development and foreign trade, a number of policy recommendations were proposed.
Review on Thermophysical Properties and Corrosion Performance of Molten Salt in High Temperature Thermal Energy Storage
Authors: Song Xiaoyun , Zhang Gaoqun , Tan Hui , Chang Liang , Cai Linhai , Xu Guizhi , Deng Zhanfeng , Han Zhibo 
Published: May 2020

Abstract
Molten salt is a type of material for high temperature thermal energy storage. The thermophysical property, thermostability, and corrosion performance of molten salt are the main points of interest in thermal energy storage field. How to further broaden the usage temperature range of molten salt, develop more molten salts with low melting points, and optimize the thermal conductivity and viscosity of materials has been widely concerned by researchers. Recently, thermal storage technology of molten salt has been applied to the field of concentrating solar power. The thermophysical property, and corrosive performance of molten salt are very important for the large-scale preparation and application of molten salt materials. Based on the classification of molten salt materials, this paper reviews the thermophysical properties of some common molten salts (carbonate, chloride, nitrate, polybasic salt, etc.), and summarizes the current research progress of improving its thermophysical properties. Moreover, the corrosive performance of several types of commonly used molten salts in thermal energy storage applications is analyzed. Besides, some corrosion protection technologies are proposed according to the current application of molten salt and the corrosion mechanism. Finally, the development trend of the application of molten salt in the field of heat storage is prospected.
Experimental Study on Indoor Thermal Environment of Capillary Radiant Cooling Based on Different Installation Methods
Authors: Yu Ze , Li Nan , Hu Xiaoqian 
Published: May 2020

Abstract
The paper, taking the room of an office building as an example, makes a comparison on the changes of response, indoor temperature field and cooling surface temperature between the capillary radiation cooling ceilings and walls at 16 °C and 18 °C through the experimental study. The results show that: 1) when the water supply temperature is set to 16 °C and 18 °C, the indoor temperature can meet the design requirements when the system works stably. 2) No matter what types of radiant cooling is used, the indoor temperature drop rate increases with the decrease of water supply temperature. In the height range of 0.7m to 1.5m from the ground, the temperature drop rate of radiant cooling ceilings is 1.8-2.4°C/h, and that of radiant cooling wall is 0.8-1.1°C/h. 3) When the system reaches the stable phase, the wall cooling system presents a state of “lower cooling and upper heating”, and the radiant cooling ceilings presents a state of “upper and lower cooling, middle heating”, but the horizontal and vertical maximum temperature difference does not exceed 2.0°C, which meets the thermal comfort requirements of the human body.
Research on the Strength of the Attachment Device of the Attached Crane
Authors: Wang Gangsen 
Published: May 2020

Abstract
Based on the construction example of Shandong International Plaza project, perform a force analysis on the attachment device of the main building crane up to 200 meters, and use a simplified model of structural mechanics to verify that the strength of the attachment device meets the requirements; based on the site conditions of the crane, a finite element calculation The model and simulation analysis under the most unfavorable conditions verify the safety of the crane. According to the simulation data, the design characteristics of the attachment device’s force characteristics are summarized, and a safer and more economical solution is obtained.
The Post-occupancy Evaluation Over the Landscape of the Campus of Zhejiang Agriculture and Forestry University
Authors: JiaFeng Shen , Wei Huang , Yun Wu 
Published: May 2020

Abstract
This paper obtains the post-occupancy evaluation over the landscape of Zhejiang Agriculture and Forestry University through a questionnaire survey. Then, this paper carries out relevant investigation over the East Lake Teahouse, which is the most important part of the campus environment, and its surrounding environment, as well as its flow of people. After that, this paper discusses and analyses the effect imposed by the landscape environment on teachers and students on campus and tourists off campus from the perspective of environmental psychology, and draws corresponding conclusions.