bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized production of a high‐performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering
Authors: Dellaquila Alessandra , Greco Gabriele , Campodoni Elisabetta , Mazzocchi Mauro , Mazzolai Barbara , Tampieri Anna , Pugno Nicola M. , Sandri Monica 
Published: December 2019

ABSTRACTSilks have been widely used as biomaterials due to their biocompatibility, biodegradability, and excellent mechanical properties. In the present work, native spider silk was used as organic template for controlled nucleation of hydroxyapatite (HA) nano‐coating that can act as biomimetic interface. Different bio‐inspired neutralization methods and process parameters were evaluated to optimize the silk functionalization. The morphology and chemical composition were investigated by scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction analysis and mechanical properties were studied through tensile tests. Results showed that the optimized protocol enabled a controlled and homogeneous nucleation of apatite nano‐crystals while maintaining silk mechanical performances after mineralization. This study reports the optimization of a simple and effective bio‐inspired nucleation process for precise nucleation of HA onto spider silk templates, suitable to develop high‐performance hybrid interfaces for bone tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48739.
Magnitude effect contributes to the domain specificity in delay discounting
Authors: Sawicki Przemysław , Markiewicz Łukasz , Białek Michał 
Published: December 2019

AbstractDiscounting is a useful framework for understanding temporal choices. A person who prefers $50 immediately over $100 in 1 month exhibits a higher discount rate than a person deciding to wait for the higher payoff. Although previous research shows that discount rates are domain‐specific, we propose an alternative to the domain specificity account. We suggest that differences in discounting alternatives across various domains may result not so much from the domains' nature per se but from differences in perceived attractiveness of the discounted alternatives. We replicated that an illustrative study evidencing domain specificity in discounting (Experiment 1) showed that people's subjective values of the payoffs in domains discounted in this experiment were different (Experiment 2) and used a novel method to match the attractiveness of the available alternatives across domains (Experiment 3). Finally, Experiment 4 showed that when matching was applied, the domain effect disappeared. We conclude that a magnitude effect can, at least partially, explain domain specificity in delay discounting.
The Statistical Style of Reasoning and the Invention of Bose‐Einstein Statistics
Authors: Monaldi Daniela 
Published: December 2019

AbstractThis paper is a preliminary exploration of the connections between the statistical style of reasoning and the research practices of statistical mechanics in the early period of the long quantum revolution. It suggests that before 1925 the instantiations of the statistical style in physics went through two phases. The first phase consisted of the formulation of the Maxwell‐Boltzmann statistics on the basis of the population‐gas analogy. The second phase was characterized by the generalization of the Maxwell‐Boltzmann statistics through analogies between ideal gas molecules and other microphysical entities, analogies that shaped and were shaped by the rise of quantum theory. Einstein's invention of the Bose‐Einstein statistics started a third phase and created the conditions of possibility for a new classification of microphysical entities according to their different statistics.
Efficacy of drug‐coated balloon angioplasty in early versus late occurring drug‐eluting stent restenosis: A pooled analysis from the randomized ISAR DESIRE 3 and DESIRE 4 trials
Authors: Koch Tobias , Cassese Salvatore , Xhepa Erion , Mayer Katharina , Tölg Ralph , Hoppmann Petra , Laugwitz Karl‐Ludwig , Byrne Robert A. , Kastrati Adnan , Kufner Sebastian 
Published: December 2019

AbstractBackgroundWhether there exist differences concerning clinical outcomes between patients presenting with early versus late DES‐ISR undergoing treatment with drug‐coated balloons (DCB) remains a scientific knowledge gap.MethodsThis is a pooled analysis including patients with DES‐ISR assigned to treatment with DCB in the setting of the ISAR DESIRE 3 and 4 trials. Clinical outcomes were evaluated according to time of occurrence of ISR after DES implantation, in patients presenting with early (≤12 months) versus late DES‐ISR (>12 months) undergoing treatment with DCB. The primary endpoint of this analysis was major adverse cardiac event (MACE), defined as the combined incidence of death, myocardial infarction and target lesion revascularization (TLR) at 12 months after DCB treatment. Secondary endpoints included the incidence of death, myocardial infarction, TLR and target lesion thrombosis at 12 months after DCB treatment.ResultsThis analysis included 352 patients, 199 patients presented with early‐ISR, 153 patients with late‐ISR. Concerning the primary endpoint, patients with early‐DES‐ISR as compared those with late‐DES‐ISR showed significant higher risk (25.9% vs. 17.0%; p = .04). In a multivariate analysis including diabetic status, clinical presentation, previous coronary bypass graft and diameter stenosis after DCB‐treatment, the adjusted hazard ratio showed significant higher risk for MACE of early‐DES‐ISR as compared to late‐DES‐ISR (HRadj = 1.8, [95% CI = 1.1–3.0], p = .02).ConclusionClinical outcome at 12 months after treatment of DES‐ISR with DCB, showed significant higher clinical event rates in patients presenting with early DES restenosis, as compared with patients presenting with late DES restenosis.
Polymer‐Assisted Co‐Assembly towards Synthesis of Mesoporous Titania Encapsulated Monodisperse PdAu for Highly Selective Hydrogenation of Phenylacetylene
Authors: Hu Mingzhen , Jin Lei , Su Xingsong , Bamonte Scott , Lu Xingxu , Gao Puxian , Suib Steven L. , Liu Ben , He Jie 
Published: December 2019

AbstractBimetallic nanoalloys have attracted great research interest in the past decades by virtue of their tunable metal‐metal synergies. The preparation of well‐defined bimetallic nanoalloys largely relies on the use of capping ligands, which brings a great challenge to utilize the surface‐accessible active sites and/or tailor bimetallic‐support interactions. In the current paper, surface‐clean, thermally stable and monodisperse PdAu nanoalloys confined in mesoporous TiO2 (PdAu@mTiO2) were prepared using evaporation‐induced self‐assembly with two colloidal templates. The hydrogenation activity of PdAu@mTiO2 was demonstrated to be approximately 6 times higher than that of PdAu nanoalloys supported on mesoporous silica due to the bimetallic‐support interactions. Our method is expected to open up new opportunities to synthesize ligand‐free and stable bimetallic nanoalloys with tailored bimetallic‐support interactions for highly efficient catalysis.
Risk of atrial fibrillation in patients with pneumoconiosis: A nationwide study in Taiwan
Authors: Hu Wei‐Syun , Lin Cheng‐Li 
Published: December 2019

AbstractBackgroundTo investigate the incidence of new‐onset atrial fibrillation (AF) among subjects with pneumoconiosis using the Taiwan National Health Insurance Research Database.HypothesisPneumoconiosis patients are at an increased risk of AF.MethodsA total of 12 209 pneumoconiosis patients were in the exposure cohort. Patients without pneumoconiosis were included as the comparison cohort. Both cohorts were matched by gender, age, comorbidity, and index year in a 1:1 manner. Multivariable cox proportional hazard model was used to calculate the adjusted hazard ratios (HRs) after adjustment for age, sex, and all comorbidities.ResultsThe risk of AF in pneumoconiosis patients was 1.30‐fold higher than that of controls (95% CI = 1.17‐1.44) was the key finding.ConclusionsPneumoconiosis is associated with increased risk of incident AF.
Response Surface Modeling and Optimization of Microwave‐Activated Persulfate Oxidation of Olive Oil Mill Wastewater
Authors: Genç Nevim , Durna Elif , Kayapinar Cicigün Hatice Kübra 
Published: December 2019

AbstractOlive oil mill wastewater (OMW) is environmentally hazardous not only because it contains high recalcitrant and toxic compounds, but also due to its high organic load and turbidity. In this study, oxidation of OMW by microwave (MW)‐activated persulfate is investigated. Box–Behnken design is applied to investigate the effects of operating conditions on operating cost, organic matter, and color removal. Multi response optimization is performed according to minimum operating cost, maximum organic matter and color removal efficiencies. At optimum conditions (persulfate anion dose of 266 g L−1, oxidation duration of 23.58 min, MW power of 567 W, and initial pH 2), chemical oxygen demand (COD) removal of 63.38%, color removal of 94.85%, and operating cost of 0.0633 Euro/g total organic carbon (TOC) removal are found. The biochemical oxygen demand (BOD5)/COD ratio is increased from 0.144 to 0.285. Results of Pareto analysis show individual effect of MW power is 92.81% for TOC removal, 15.52% for color removal, 68.99% for operating cost, respectively. According to the results, it is not recommended to use this process as an ultimate treatment unit due to the high amount of oxidizing agent consumed. Instead, it is recommended to be used as a pre‐ or post‐treatment step.
The impact of miR‐183/182/96 gene regulation on the maturation, survival, and function of photoreceptor cells in the retina
Authors: Amini‐Farsani Zeinab , Asgharzade Samira 
Published: December 2019

AbstractMicroRNAs (MiRNAs) play important roles in posttranscriptional processes to regulate gene expression. MiRNAs control various biological processes, such as growth, development, and differentiation. The continuous physiological function of photoreceptors and retinal pigment epithelium requires precise regulation to maintain their homeostasis and function; hence, these cells are highly susceptible to premature death in retinal degenerative disorders. MiRNAs are essential for the retinal cell maturation and function; the miR‐183 cluster represents one of the most important regulatory factors for the photoreceptor cells. Various studies together with bioinformatics analyses have shown that many genes contributing to the differentiation pathway of photoreceptors are targets of the miR‐183 cluster, and the miR‐183 cluster dysregulation causes certain defects in the differentiation of the photoreceptors and other retinal neurons by influencing the expression of target genes. Misexpression of miR‐183 cluster in the human retinal epithelial cells leads to the reprogramming and transformation of these cells to neuron‐ and photoreceptor‐like cells, which are associated with the expression of neuron‐ and photoreceptor‐specific markers in human retinal pigment epitheliums cells. The knockout of this cluster causes the destruction of the outer segment of the photoreceptors, which subsequently causes the cells to exhibit severe susceptibility to light and eventually degenerate. Hundreds of target genes in this family are likely to affect the development and maintenance of the retina. Identifying the genes that are regulated by the miRNA‐183 cluster provides researchers with important insights into the complex development and regeneration mechanism of the retina and may offer a new way for maintaining and regenerating photoreceptor cells in neurodegenerative diseases.
An improved term weighting scheme for text classification
Authors: Tang Zhong , Li Wenqiang , Li Yan 
Published: December 2019

SummaryText representation is a necessary and primary procedure in performing text classification (TC), which first needs to be obtained through an information‐rich term weighting scheme to achieve higher TC performance. So far, term frequency‐inverse document frequency (TF‐IDF) is the most widely used term weighting scheme, but it suffers from two deficiencies. First, the global weighting factors IDF in TF‐IDF approaches infinity if a certain term does not occur in a text. Second, the IDF is equal to zero if a certain term appears in any text. To offset these drawbacks, we first conduct an in‐depth analysis of the current term weighting schemes, and subsequently, an improved term weighting scheme called term frequency‐inverse exponential frequency (TF‐IEF) and its various variants are proposed. The proposed method replaces IDF with the new global weighting factor IEF to characterize the global weighting factor log‐like IDF in the corpus, which can greatly reduce the effect of feature (term) with high local weighting factor TF in term weighting. As a result, a more representative feature can be generated. We carried out a series of experiments on two commonly used data sets (corpora) utilizing Naïve Bayes and support vector machine classifiers to validate the performance of our proposed schemes. Experimental results explicitly reveal that the proposed term weighting schemes come with better performance than the compared schemes.
The effectiveness of stabilization appliance therapy among patients with myalgia
Authors: Noguchi Tomoyasu , Kashiwagi Kosuke , Fukuda Kenichi 
Published: December 2019

AbstractBackgroundThe efficacy of stabilization appliance therapy for masticatory muscle pain is debated. Therefore, there are currently no clear usage standards. We analyzed patient factors influencing its efficacy and characterized masticatory muscle pain subtypes to determine appropriate therapy candidates.MethodsThis case series study recruited patients diagnosed with local myalgia or myofascial pain and used variables related to temporomandibular disorders in the analysis. We used temporary appliance to screen patients for sleep bruxism for 2 weeks. Afterwards, we initiated therapy with stabilization appliances. Efficacy was evaluated via tenderness intensity during muscle palpation and the treatment satisfaction score after 2 months of treatment.ResultsWe analyzed 62 (91%) patients. Tenderness upon muscle palpation was mitigated in 27 patients. Mitigated tenderness odds ratios were 0.035 for myofascial pain, 0.804 for 15‐item Patient Health Questionnaire scores, and 1.915 for facet length. Thirty‐nine patients expressed satisfaction; satisfaction odds ratios were 0.855 for 9‐item Patient Health Questionnaire scores, 1.606 for facet length, and 4.023 for awake bruxism awareness.ConclusionsStabilization appliance therapy is most effective for patients with awake bruxism awareness, local myalgia, long facets, and no psychosocial risk factors.
Ion‐induced PCR strategy for mercury detection
Authors: Chen Gangyi , Wang Wei , Yuan Yi , Dong Juan , Cui Xin , Huang Xin , Deng Yun , Tang Zhuo 
Published: December 2019

AbstractMercury contamination is one of the most serious environmental problems. It can cause serious effects on the human health, such as case damage in the brain, nervous system, immune system, and kidney failure. Therefore, development of an accurate, sensitive, and simple operational detection method for mercury is very necessary. Herein, we report a new strategy for mercury ion detection based on commonly used PCR technique. High selectivity and sensitivity were achieved by the formation of the thymine‐Hg‐thymine (T‐Hg‐T) unnatural base pair at the 3’‐end of PCR primers. The detection results of PCR amplification in presence of mercury ion could be reported either by using agarose gel analysis or through real‐time fluorometric dye tracing for different detection purposes. To our knowledge, this study represents the first application of PCR based technique to the detection of metal ions.
Effect of enzyme‐assisted hydrolysis on protein pattern, technofunctional, and sensory properties of lupin protein isolates using enzyme combinations
Authors: Schlegel Katharina , Sontheimer Katharina , Eisner Peter , Schweiggert‐Weisz Ute 
Published: December 2019

AbstractThe modification of lupin protein isolates (LPI) by means of enzymatic hydrolysis (Lupinus angustifolius cultivar Boregine) was performed with four enzyme preparations (Alcalase 2.4 L, Papain, Corolase 7089, and Neutrase 0.8 L) in a one‐ and two‐step process to determine the efficacy for the destruction of major IgE‐reactive polypeptides and the evaluation of the technofunctional and sensory properties of lupin protein hydrolysates. Combinations of Alcalase 2.4 L and Papain were most effective in the degradation of polypeptides in L. angustifolius as measured by sodium dodecylsulfate–polyacrylamide gel electrophoresis. The enzymatic hydrolysis of the LPI increased their technofunctional properties such as protein solubility, foam activity, and emulsifying capacity almost independently of the enzyme preparation used. The sensory results showed a significant increase in bitterness from 1.9 for LPI to 5.7 for the combination of Alcalase 2.4 L and Papain in one‐step process. The aroma attributes of the hydrolysates were very similar to untreated LPI. The results of this study show the possibility of enzymatic hydrolysis of LPI to destroy the major IgE‐reactive polypeptides that increase the technofunctional properties of the isolates and thus their use in human nutrition as food ingredients.
Accelerating Fuel Cell Development with Additive Manufacturing Technologies: State of the Art, Opportunities and Challenges
Authors: Tai X. Y. , Zhakeyev A. , Wang H. , Jiao K. , Zhang H. , Xuan J. 
Published: December 2019

AbstractIn recent years, the use of additive manufacturing (AM) has been demonstrated in the fabrication of components in polymer electrolyte membrane fuel cell, solid oxide fuel cell (SOFC), microbial fuel cell (MFC) and laminar flow‐based fuel cell (LFFC). Various AM technologies have been successfully demonstrated in fuel cell manufacturing include material extrusion, powder bed fusion, vat photopolymerization and binder jetting. One of the unique advantages of AM is the ability to handle sophisticated design with features ranging from macro to micro scales, which are inaccessible by conventional manufacturing technologies. Well‐designed complex 3D structures were reported to have the potential for increasing the performance of fuel cells. Therefore, AM presents itself as a promising fabrication method to promote the development of fuel cells. Besides, AM also showed its specialty in time‐saving, flexibility, and on‐demand manufacturability in the fabrication of fuel cell components. In spite of the prospects of AM in fuel cells, more studies and researches are required to overcome challenges, such as availability of material, manufacturing quality, and the costs. This review focuses on the advantages and applications of additive manufacturing that enable improvement in fuel cell performance. The critical challenges and directions for future development are also highlighted.
Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV
Authors: Zahr Natalie M. , Sullivan Edith V. , Pohl Kilian M. , Pfefferbaum Adolf , Saranathan Manojkumar 
Published: December 2019

AbstractVolumes of thalamic nuclei are differentially affected by disease‐related processes including alcoholism and human immunodeficiency virus (HIV) infection. This MRI study included 41 individuals diagnosed with alcohol use disorders (AUD, 12 women), 17 individuals infected with HIV (eight women), and 49 healthy controls (24 women) aged 39 to 75 years. A specialized, high‐resolution acquisition protocol enabled parcellation of five thalamic nuclei: anterior [anterior ventral (AV)], posterior [pulvinar (Pul)], medial [mediodorsal (MD)], and ventral [includingventral lateral posterior (VLp)andventral posterior lateral (VPl)]. An omnibus mixed‐model approach solving for volume considered the “fixed effects”of nuclei, diagnosis, and their interaction while covarying for hemisphere, sex, age, and supratentorial volume (svol). The volume by diagnosis interaction term was significant; the effects of hemisphere and sex were negligible. Follow‐up mixed‐model tests thus evaluated the combined (left + right) volume of each nucleus separately for effects of diagnosis while controlling for age and svol. Only the VLp showed diagnoses effects and was smaller in the AUD (p= .04) and HIV (p= .0003) groups relative to the control group. In the AUD group, chronic back pain (p= .008) and impaired deep tendon ankle reflex (p= .0005) were associated with smaller VLp volume. In the HIV group, lower CD4 nadir (p= .008) was associated with smaller VLp volume. These results suggest that the VLp is differentially sensitive to disease processes associated with AUD and HIV.
The effect of femoral head size on edge loading in metal‐on‐metal hip joint replacement under dynamic separation conditions
Authors: Liu Feng , Lian Chao , Feng Li , Wang Junyuan , Du Wenhua 
Published: December 2019

AbstractEdge loading that occurs in hip joint replacements due to dynamic separation of the joint bearings has been shown to cause severe wear for meal‐on‐metal bearings. In the present study, the multibody dynamics model for metal‐on‐metal (MoM) hip joints with a medial–lateral translational mismatch in the centers of rotation of the cup and head has been developed to predict the dynamic separation and contact force of edge loading under gait loading conditions. The effects of larger head diameters (28–55 mm), in combination with the translational mismatch (0–4 mm) and varied cup inclination angles (45°–65°), on edge loading of MoM bearings have been computationally investigated. For the given translational mismatch, increasing head diameters results in negligible effects on the dynamic separation, contact force and severity of edge loading. Increasing head size also leads to increased offset loading torque which has been found to reach at the level that may cause cup loosening under larger translational mismatch at 4 mm. The result highlights the importance of the cup inclination angle of 45° and a lower translational mismatch to avoid severe edge loading.