bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases
Authors: Bodolea Constantin , Hiriscau Elisabeta I. , Buzdugan Elena-Cristina , Grosu Alin I. , Stoicescu Laurențiu , Vesa Ștefan , Cauli Omar 
Published: August 2020

Background:
Frailty syndrome is characterized by multisystem dysregulation frequently
found in older individuals or even in younger patients with chronic disabling diseases such as cardiovascular
diseases.

Objective:
To determine whether peripheral blood cell count, and its subpopulations, red blood cell and
platelets, morphology and different ratios (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio
and red blood distribution width-to-platelet ratio) are associated with cardiac frail patients, and through
this to improve the prediction of frailty status in patients with cardiovascular diseases.

Methods:
An observational, retrospective, cohort study enrolling 179 patients with cardiovascular
disease divided into two groups: non-frail group (100 pts) and frail group (79 pts), a cohort detached
from the Frail.RO study. The frailty was evaluated based on the Fried criteria; haematological markers,
sociodemographic data, and variables related to cardiovascular diseases and comorbidities were also
recorded.

Results:
Lower lymphocytes, platelet count, and neutrophil-to-lymphocyte ratio were significantly
associated with a more severe frailty syndrome. Regarding red blood cells, haemoglobin concentration
and red cell distribution width significantly correlated with the severity of the frailty syndrome. Receiver
operating characteristic curve analysis for these markers associated with the frailty syndrome
revealed an acceptable sensitivity of 66 % and specificity of 65% to identify frail individuals. Malnutrition
and hypercholesterolemia are relevant predictors for identifying frailty in hospitalized cardiovascular
patients.

Conclusion:
The evaluation of peripheral blood cell composition routinely measured in clinical practice
can represent a valuable, but limited indicator, to diagnose frailty syndrome and eventually, the
effects of interventions in frail patients with cardiovascular diseases.
A Novel Long-circulating DOX Liposome: Formulation and Pharmacokinetics Studies
Authors: Xiao Peihong , Zhao Juan , Huang Yi , Jin Rongrong , Tang Zhonglan , Wang Ping , Song Xu , Zhu Hongfei , Yang Zibin , Yu Nie 
Published: August 2020

Background:
Doxorubicin (DOX) is a leading chemotherapeutic in cancer treatment
because of its high potency and broad spectrum. Liposomal doxorubicin (Doxil®) is the first
FDA-approved PEG-liposomes of DOX for the treatment of over 600,000 cancer patients, and
it can overcome doxorubicin-induced cardiomyopathy and other side effects and prolong life
span. The addition of MPEG2000-DSPE could elevate the total cost of cancer treatment.

Objective:
We intended to prepare a novel DOX liposome that was prepared with inexpensive
materials egg yolk lecithin and Kolliphor HS15, thus allowing it to be much cheaper for clinical
application.

Methods:
DOX liposomes were prepared using the combination of thin-film dispersion ultrasonic
method and ammonium sulfate gradient method and the factors that influenced formulation
quality were optimized. After formulation, particle size, entrapment efficiency, drug loading,
stability, and pharmacokinetics were determined.

Results:
DOX liposomes were near-spherical morphology with the average size of 90 nm and
polydispersity index (PDI) of less than 0.30. The drug loading was up to 7.5%, and the entrapment
efficiency was over 80%. The pharmacokinetic studies showed that free DOX could be
easily removed and the blood concentration of free DOX group was significantly lower than
that of DOX liposomes, which indicated that the novel DOX liposome had a certain sustainedrelease
effect.

Conclusion:
In summary, DOX liposome is economical and easy-prepared with prolonged circulation
time.

Lay Summary:
Doxorubicin (DOX) is a leading chemotherapeutic in cancer treatment because
of its high potency and broad spectrum. Liposomal doxorubicin (Doxil®) is the first FDAapproved
PEG-liposomes of DOX to treat over 600.000 cancer patients, overcoming doxorubicin-
induced cardiomyopathy and other side effects and prolonging life span. The addition of
MPEG2000-DSPE could elevate the total cost of cancer treatment. We intend to prepare a novel
DOX liposome prepared with inexpensive materials egg yolk lecithin and Kolliphor HS15, thus
allowing it to be much cheaper for clinical use. The novel DOX liposome is economical and
easy-prepared with prolonged circulation time.
A New Approach for Simplification of Logical Propositions with Two
Propositional Variables Using Truth Tables
Authors: Nabulsi Maher , Hamad Nesreen , Alqatawneh Sokyna 
Published: August 2020

Background:
Propositions simplification is a classic topic in discrete mathematics that is applied in different areas of science such as programs development and digital circuits design. Investigating alternative methods
would assist in presenting different approaches that can be used to obtain better results. This paper proposes a new
method to simplify any logical proposition with two propositional variables without using the logical equivalences.

Methods:
This method is based on constructing a truth table for the given proposition, and applying one of the following two concepts: the sum of Minterms or the product of Maxterms which has not been used previously in discrete mathematics, along with five new rules that are introduced for the first time in this work.

Results:
The proposed approach was applied to some examples, where its correctness was verified by applying the
logical equivalences method. Applying the two methods showed that the logical equivalences method cannot give
the simplest form easily; especially if the proposition cannot be simplified, and it cannot assist in determining
whether the obtained solution represent the simplest form of this proposition or not.

Conclusion:
In comparison with the logical equivalences method, the results of all the tested propositions show
that our method is outperforming the current used method, as it provides the simplest form of logical propositions
in fewer steps, and it overcomes the limitations of logical equivalences method.

Originality/value:
This paper fulfils an identified need to provide a new method to simplify any logical proposition with two propositional variables.
Excessive Smartphone Use and Self-Esteem Among Adults With Internet Gaming Disorder: Quantitative Survey Study
Authors: Kim Hyunmin , Choi In Young , Kim Dai-Jin 
Published: August 2020

Background
Smartphone overuse can harm individual health and well-being. Although several studies have explored the relationship between problematic or excessive smartphone use and mental health, much less is known about effects on self-esteem, which is essential in having a healthy life, among adults with mental health disorders, including internet gaming disorder. Furthermore, given that smartphone usage differs by gender, little is known about gender differences in the relationship between smartphone overuse and self-esteem.

Objective
The objective of this study was to assess self-esteem among individuals with mental health disorders and explore the relationship with excessive smartphone use.

Methods
Participants were selected based on their responses to the internet gaming disorder assessment, which includes 9 items developed based on Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) criteria, from among a Korean cohort of smartphone users aged 20-40 years, resulting in a sample of 189 participants (men:120, women: 69). The Rosenberg self-esteem scale and the Korean smartphone addiction proneness scale were utilized to assess the outcome self-esteem with excessive smartphone use as the primary independent variable. Guided by the Bowlby attachment theory and prior studies, we selected several covariates. Generalized linear regression analyses, as well as subgroup analyses by gender, were performed.

Results
Among adults with internet gaming disorder, the average Korean smartphone addiction proneness scale score was significantly higher in women than that in men (41.30 vs. 37.94; P=.001), and excessive smartphone use was significantly more prevalent in women than it was in men (30.43% vs. 20.83%; P=.02). Our findings from the generalized linear regression analyses indicated that an increase in Korean smartphone addiction proneness scale score had a negative relationship with self-esteem among those with internet gaming disorder (β=–0.18, P=.001). Furthermore, our interaction models showed that, among those with internet gaming disorder, more men than women had lower self-esteem associated with an increase in Korean smartphone addiction proneness scale score and a high degree of smartphone overuse (β=–0.19, P=.004; β=–3.73, P<.001).

Conclusions
Excessive smartphone use was found to be adversely associated with self-esteem among young and middle-aged adults with internet gaming disorder; notably, more men than women were negatively influenced (regarding self-esteem) by smartphone overuse. Based on our findings, more efforts should be made to reduce excessive or problematic smartphone use by considering developing public health interventions or policy, particularly among those with mental health disorders such as internet gaming disorder.
Kinerja Badan Permusyawaratan Desa Dalam Menyalurkan Aspirasi Masyarakat di Desa Bantaran Kecamatan Bantaran Kabupaten Probolinggo
Authors: Hilman Pahlawan Regy 
Published: August 2020

Penelitian ini bertujuan untuk (1) mendeskripsikan Kinerja Badan Permusyawaratan Desa (BPD) dalam menyalurkan aspirasi masyarakat di Desa Bantaran (2) penghambat Kinerja Badan Permuswaratan Desa dalam menyalurkan aspirasi masyarakat di Desa Bantaran (3) solusi mengatasi hambatan BPD dalam penyaluran aspirasi masyarakat di Desa Bantaran. Metode penelitian menggunakan deskriktif kualitatif yang di lakukan di Kantor Desa dan Masyarakat Bantaran pada bulan Januari 2019 sampai Mei 2019. Subjek penelitian antara lain ketua BPD, kepala desa, dan tokoh masyarakat. Pengumpulan data dilakukan melalui observasi, dokumentasi kegiatan serta melakukan wawancara. Data dianalisis melakui tahab pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Tahap ahir adalah menguji keabsahan data dengan prosedur Trianggulasi sumber. Hasil dalam penelitian ini menunjukkan (1) Kinerja Badan Permusyawaratan Desa (BPD) dalam menyalurkan aspurasi masyarakat di Desa Bantaran kurang sesuai dengan Undang-Undang No 6 Pasal 55 Tahun 2014. (2) penghambat Kinerja Badan Permuswaratan Desa (BPD) dalam menyalurkan aspirasi masyarakat di Desa Bantaran adalah tidak adanya surat keterangan (SK) untuk kepengurusan BPD, tidak mengetahui tugas pokok dan fungsinya, lebih mementingkan pekerjaan sehari-hari dibandingkan di BPD. (3) solusi mengatasi hambatan BPD dalam penyaluran aspirasi masyarakat motivasi anggota BPD, sarana dan prasarana, dan sumber daya manusia.
Penerapan Model Pengajaran Terarah Dalam Meningkatkan Hasil Belajar PPKn Di SMA Negeri 1 Jiwan Madiun
Authors: Suharno Suharno 
Published: August 2020

Penelitian ini bertujuan untuk mengetahui penerapan model pengajaran terarah untuk meningkatkan hasil belajar PPKn di SMA Negeri 1 Jiwan Madiun. Penelitian ini merupakan penelitian yang dirancang dengan rancangan penelitian tindakan kelas. Tujuan utama penelitian tindakan kelas adalah untuk meningkatkan kualitas pembelajaran, bukan untuk menghasilkan pengetahuan. Subyek penelitian yang digunakan dalam penelitian nini adalah siswa kelas XI-MIPA 1 SMA Negeri 1 Jiwan Kabupaten Madiun tahun pelajaran 2018/2019 dengan jumlah 36 orang siswa. Hasil analisis data menunjukkan peningkatan nilai rata-rata. Pada siklus I nilai rata-rata PPKn sebesar 68,53 dan pada siklus II diperoleh nilai rata-rata 76, serta pada siklus III diperoleh nilai rata-rata 88,67. Hal ini membuktikan bahwa, penerapan model pengajaran terarah dapat meningkatkan hasil belajar siswa kelas XI-MIPA 1 SMA Negeri 1 Jiwan Kabupaten Madiun tahun pelajaran 2018/2019.
Analisis Perdagangan BjKU Yang Tidak Sesuai Standar Nasional Indonesia
Authors: Hidayat Gandha Syah 
Published: August 2020

Tujuan dari penelitian ini adalah menganalisis perdagangan BjKU yang tidak sesuai dengan standar nasional Indonesia. Penelitian menggunakan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data menggunakan observasi, wawancara, studi dokumentasi. Teknik penentuan informan menggunakan purposive.Hasil penelitian menunjukkan bahwa baja keperluan umum yang diperdagangkan di wilayah Indonesia wajib memenuhi Standar Nasional Indonesia (SNI) sebagaimana Peraturan Menteri Perindustrian Nomor: 35/M-IND/PER/5/2014 tentang Pemberlakuan Standar Nasional Indonesia Baja Batangan Keperluan Umum Secara Wajib. Sementara berdasarkan hasil pengujian yang dikeluarkan oleh Balai Besar Bahan dan Barang Teknik (B4T) terhadap besi baja ukuran 6 mm, besi baja ukuran 10 mm SIS, besi baja ukuran 12 mm SIS menyatakan BjKU yang diperdagangkan tidak memenuhi standar yang ditetapkan. CV. Karya Virkan telah melanggar aturan terkait perdagangan baja batangan untuk keperluan umum dan dapat dijerat Pasal 113 Undang-undang RI No. 7 tahun 2014 tentang Perdagangan, Pasal 8 Ayat (1) huruf c dan Pasal 62 Ayat (1) dan Undang-undang RI No. 8 tahun 1999 tentang Perlindungan Konsumen.
The role of cytomegalovirus infection in the development of the nervous system lesions and retinitis in people living with HIV
Authors: Kasimova R. I. , Musabaeva N. E. , Pulatova R. Z. 
Published: August 2020

Purpose: identification of patients with manifest forms of CMVI among PLHIV with neurological manifestations and eye lesions.Materials and methods: 85 patients with CD4 less than 330 cells were examined who quantified CMV DNA in blood leukocytes. Patients depending on CD4 were divided into 2 groups: group 1 — patients with values of CD4<00 cells (n=42) and group 2 — patients with values of CD4 from 101 to 330 cells (n=43). According to indications, the patient underwent lumbar puncture followed by determination of CMV DNA in the cerebrospinal fluid.Results and discussion: There were 20 patients in the III clinical stage (23,5%) and 65 (76,5%) in the IV clinical stage. VL CMV among patients with CD4 less than 100 cells was positive in 52,4%, and with CD4 more than 101 cells in 18,6%. VL CMV of less than 1000 copies was detected in 23,8% in patients with CD4 less than 100 cells and in 16,3% in patients with CD4 101–330 cells. The diagnosis of CMV retinitis was made in 6 out of 21 patients (28,6%) with CMV DNA in the blood. CMV DNA in CSF was determined in 3 patients. Half of 42 patients (52,4%) with severe and final stages of cognitive and motor impairment showed a generalized form of CMVI. Physical, clinical and biochemical parameters are not highly informative for determining the generalization of CMVI.
Development of Mathematics Teaching Material Based on Lampungnese Ethomathematics
Authors: Endah Wulantina  , Maskar Sugama 
Published: August 2020

Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk menghasilkan bahan ajar matematika berbasis Lampungnese etnomatematics. Metode penelitian terdiri dari (1) pengumpulan data; (2) perancangan bahan ajar; (3) pengembangan bahan ajar; (4) validasi I bahan ajar; (5) revisi I hasil validasi; (6) validasi II; (7) revisi II; (8) uji coba produk; (9) revisi akhir dan produksi bahan ajar. Pengambilan sampel dilakukan pada siswa kelas IV di SDN 3 Kemiling Permai. Hasil validasi bahan ajar dari ahli matematika dan ahli budaya Lampung memberikan skor rata-rata 3,86 yang dikategorikan baik atau layak, sedangkan validasi bahan ajar oleh guru matematika memberikan skor rata-rata 3,95 yang dikategorikan baik atau layak. Pada uji coba kelas kecil diperoleh skor rata-rata angket respon siswa sebesar 3,72 yang dikategorikan baik atau layak. Kemudian uji coba kelas besar diperoleh skor rata-rata angket respon siswa sebesar 3,89 yang dikategorikan baik atau layak. Kesimpulan dari penelitian ini adalah bahan ajar matematika berbasis lampungnese etnomatematics dikategorikan baik dan layak digunakan dalam pembelajaran matematika di sekolah dasar.
Kata Kunci: bahan ajar matematika, lampungnese etnomatematics
Pengembangan Buku Ajar Teori Graf untuk Meningkatkan Kemampuan Representasi Matematis Siswa pada Mata Kuliah Matematika Diskrit
Authors: Daniel Farida , Taneo Prida N. L. 
Published: August 2020

Abstrak
Penelitian ini bertujuan untuk mengembangkan buku ajar teori graf yang valid, praktis dan efektif dalam meningkatkan kemampuan representasi matematis mahasiswadalam pembelajaran teori graf pada matakuliah matematika diskrit.Metode yang digunakan adalah penelitian dan pengembangan dengan desain pengembangan mengikuti model Plomp yang terdiri dari lima tahapan berupa (1) investigasi awal, (2) desain, (3) realisasi/konstruksi, (4) tes, evaluasi dan revisi, (5) implementasi. Subjek pada penelitian ini adalah mahasiswa yang mengambil mata kuliah matematika diskrit, tahun akademik 2018/2019 program studi pendidikan Matematika STKIP Soe sebanyak dua kelas.Teknik pengumpulan data penelitian berupa observasi, tes dan angket.Produk berupa buku ajar teori graf yang dikembangkan diuji validitasnya berdasarkan hasil penilaian dari tim ahli sebagai validator. Kepraktisan produk diuji menggunakan analisis angketrespon mahasiswa dan dosen. Uji keefektifan buku ajar dalam meningkatkan kemampuan representasi matematis dilakukan melalui penelitian quasi eksperimen dengan teknik analisis menggunakan uji t sampel independen dan skor gain normalisasi. Hasil penelitian menunjukkan bahwa buku ajar teori graf yang dikembangkan valid, praktis dan efektif dalam meningkatkan kemampuan representasi matematis mahasiswa.
Kata Kunci: buku ajar, matematika diskrit, representasi matematis, teori graf
Eu Não Alcancei este Tempo: Fotografia e ancestralidade no Alto da bela Vista, Itaparica (BA)
Authors: D'Amato Andréa Silva 
Published: August 2020

Resumo: Cheguei à casa de D. Zeinha com algumas fotos nas mãos. Queria ouvir o que poderiam me contar. Licinha, sua filha, logo falou: nossa comunidade não tem memória. A prosa foi avançando. Esse aqui é tio Izidoro. Vovó Julia aqui. Emocionada Licinha vai até outro cômodo e volta com uma pasta com mais fotografias. Provoquei: viu só, quanta memória. Ela arrematou: é, a memória estava toda empoeirada na sacola. A experiência a que se propõe esta pesquisa tem lugar no Alto da Bela Vista, em Itaparica (BA) e envolve os moradores do entorno do terreiro Omo Ilê Agboulá e o culto aos ancestrais, Babá-Egùn. A ideia é comtemplar presenças e ausências acionadas por imagens. Eu não alcancei este tempo. Escutei isso repetidas vezes. A frase parece trazer a tona a astúcia das fotografias contra uma razão linear. As potencialidades de associação entre o fazer etnográfico e as narrativas geradas com as fotografias permeiam as reflexões a serem compartilhadas neste artigo. Palavras Chaves: Ancestralidade. Fotografia. Memória. I DID NOT REACH THAT TIMEPHOTOGRAPHY AND ANCESTRY AT ALTO DA BELA VISTA, ITAPARICA (BAHIA) Abstract: I arrived at Ms. Zeinha’s house with some pictures in hands. I wanted to hear what they could tell me. Licinha, her daughter, has soon spoken: our community doesn’t have memory. The prose was going on. This is uncle Izidoro. Grandma Julia here. Thrilled, Licinha goes to another room and come back with a folder with more photos. I provoked: look at these, there are a lot of memory. She answered: yes, all this memory was dusty in a bag. The experience this research describes has place at Alto da Bela vista, Itaparica (Bahia), and involves the surrounding habitants of the terreiro Omo Illê Agboulá and the ancestors cult, Babá-Egùn. The idea is to look on presences and absences activated by images. I did not reach that time. I heard that repeated times. This sentence seems to bring up the astuteness of photography against a linear rationality. The potentialities of the combination between ethnography and the narratives created with the pictures surround the reflections shared in this article.Keywords: Ancestry. Photography. Memory.
Descolonizar el Archivo y el Museo: Imágenes intervenidas y museología social con los pueblos Inga, Kamëntsá y Arhuaco (Colombia)
Authors: Pérez Benavides Amada Carolina 
Published: August 2020

Resumen: A finales del siglo XIX y comienzos del siglo XX las comunidades indígenas en diferentes países de América Latina enfrentaron una nueva arremetida que pretendía transformarlos y apoderarse de sus tierras y sus recursos. Buena parte de los estados nacionales, recientemente creados, establecieron convenios con los misioneros católicos con el objetivo de civilizar a los indígenas. Durante las décadas que estuvieron a cargo de las misiones, los frailes de diferentes órdenes religiosas produjeron una serie de registros visuales y escritos que componen una amplia documentación. Algunos de tales registros se encuentran actualmente en archivos nacionales e internacionales, y, en términos generales, las comunidades indígenas no han tenido acceso a ellos. El presente artículo da cuenta de una experiencia de investigación colaborativa en la que las imágenes del archivo misional son intervenidas por parte de diferentes personas de los pueblos inga y kamëntsá del Valle del Sibundoy y arhuaco de la Sierra Nevada de Santa Marta (Colombia) y resignificadas para la elaboración de una exposición museal. Palabras clave: Misiones católicas. Archivo. Fotografía. Museología social. Pueblos inga y kamëntsá. Pueblo arhuaco INTERVENTIONS TO DECOLONIZE THE PHOTOGRAPHIC ARCHIVE AND THE MUSEUM; SOCIAL MUSEOLOGY WITH THE INGA, KAMËNTSÁ AND ARHUACO PEOPLES Abstract: In the end of the 19th century and the 20th century in the indigenous communities in different countries of Latin America, they faced a new attack that intended to transform them and seize their resources and resources. Most of the national states, recently created, established agreements with Catholic missionaries for the purpose of civilizing indigenous peoples. During the decades that they were in charge of the missions, the frails of different religious orders produced a series of visual and written records that compose a broad documentation. Some of these records are currently in national and international archives, and, in general terms, the indigenous communities have not had access to them. The present article of a collaborative investigation experience in which the images of the misional archive are intervened by different people of the pueblos inga and kamëntsá del Valle del Sibundoy and the arhuaco de la Sierra Nevada de Santa Marta (Colombia) and resignified for the elaboration of a museum exhibition.Keywords: Catholic missions. Arquive. Photography. Social museology. Inga and kamëntsá people. Arhuaco people