bluuebunny/crossref_metadata_2025_split huggingface dataset:
The case report of the impact of coach self-supportive behaviors on the communication effectiveness with depressed athletes: The mediating role of intrinsic motivation
Authors: Zeng Jing , Liu Kun , Qin Li , Shi Yan 
Published: December 2024

Rationale:
Coach autonomy-supportive behaviors are a crucial factor in the communication effectiveness with athletes experiencing depressive moods. Therefore, clarifying the relationship between coach autonomy-supportive behaviors and the communication effectiveness with athletes experiencing depressive moods is of significant importance for promoting effective communication between coaches and athletes. This study employs in-depth interviews, questionnaires, and stepwise regression analysis, using purposive sampling to investigate coaches and athletes experiencing depressive moods from various regions, levels, genders, and sports in China. The study examines the impact of coach autonomy-supportive behaviors on their communication effectiveness, as well as the mediating role of intrinsic motivation variables, measuring and testing these variables.

Patient concerns:
The participants care about whether the coach’s autonomous support behavior can promote communication between them and the coach.

Diagnoses:
The athletes participating in the test have a certain degree of depression.

Interventions:
For these athletes, coaches adopt autonomous support behavior in training practice to support their decision-making and meet their psychological needs.

Outcomes:
Coach autonomous support behavior has a positive supportive effect on the communication effect between athletes with depressive emotions and coaches.

Lessons:
(1) Coach autonomy-supportive behaviors can positively predict the communication effectiveness between coaches and athletes experiencing depressive moods; (2) Intrinsic motivation partially mediates the relationship between coach autonomy-supportive behaviors and communication effectiveness between coaches and athletes experiencing depressive moods. The study concludes that coaches can promote athletes’ intrinsic motivation by supporting and encouraging them to make their own choices and affirming the outcomes of those choices. This approach can alleviate athletes’ depressive moods and foster their willingness to actively communicate and share their feelings with coaches, thereby enhancing communication effectiveness.
Effects of cilostazol on cognitive function and dementia risk: A systematic review and meta-analysis
Authors: Cheng Xiaofang , Ren Qiuxia , Zhi Jianxia , Chen Quanhui , Luo Kaifa , Yu Liheng , Jiao Shusheng 
Published: December 2024

Background:
Cilostazol is an antiplatelet drug and is used for stroke prevention and symptomatic peripheral vascular disease. Studies have reported the effects of cilostazol on cognitive function, but the results are inconsistent and have not been systematically assessed.

Methods:
We systematically searched the PubMed, Embase, and Cochrane databases for relevant clinical studies. The primary outcome was the change in Mini-mental State Examination (MMSE) scores from baseline to the last available follow-up. The secondary outcome was dementia risk. Mean differences and 95% confidence intervals (CIs) were calculated for combining MMSE scores, and the pooled odds ratios and 95% CIs were used to calculate the association between use of cilostazol and dementia risk.

Results:
Overall, 8 eligible studies met inclusion criteria were pooled in meta-analysis. Though with a trend toward favoring cilostazol, the pooled changes in MMSE scores from baseline showed no significant difference in mild cognitive impairment and dementia patients (mean differences 1.02, 95% CI −0.53 to 2.57, P = .195). For secondary outcome, cilostazol reduced the risk of dementia in patients without prior history of dementia (pooled odds ratios 0.90; 95% CI 0.87 to 0.92; P = .000).

Conclusion:
These results suggest the potential for cilostazol treatment in the suppression of cognitive decline and prevention of progression to dementia. However, the lack of blinding in most studies is likely to cause an overestimation of the effect sizes, and further well-designed studies are also needed.
Correlation of miRNAs with infarct volume in patients with acute ischemic stroke: A systematic review
Authors: Yang Yanmeng , Wang Guangming , Tang Yanlong 
Published: December 2024

Background:
Rapid diagnosis of acute ischemic stroke (AIS) remains challenging, and reliable biomarkers are needed. MicroRNAs (miRNAs) are endogenous small noncoding regulatory RNA molecules present in the serum, plasma, and saliva. miRNAs are considered to be sensitive biomarkers of tissue damage because of their high stability and relative tissue specificity. The aim of this systematic review was to assess the correlation between miRNAs and infarct volume in patients with AIS, to provide a basis for predicting ischemic stroke onset and improving prognosis in the clinic, among others.

Methods:
From the search of published Chinese and English literature in PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to July 1, 2023, we performed a descriptive summary of the included studies. And use of 12 quality evaluation items and Cochrane Risk of Bias tool to assess the quality of included studies.

Results:
This systematic review included 17 studies with articles involving 1443 cases were included in the data extraction for a total of 18 miRNA indicators. Among them, 9 indicators were positively associated with infarct volume in patients with AIS, including endothelial microvesicles-miR-155, miR-146b, miR-181c, miR-182, miR-34a, miR-92a, miR-122-5p, miR-451a, and miR-409-3P.

Conclusions:
This study shows that miRNA can be used as a biomarker for AIS, reflecting the severity of neurological deficits in this patient and providing a basis for clinical judgement of the patient’s prognosis.
Primary sarcomatoid carcinoma of the trachea: A case report and literature review
Authors: Yu Xiuwen , Huang Mingqi , Ge Haiyan , Yang Junjie , Huang Bin , Xu Jialing 
Published: December 2024

Rationale:
Primary sarcomatoid carcinoma of the trachea (PSCT) is a rare malignant tumor of the lower respiratory tract. Pathological types of tracheal sarcomatoid carcinoma (TSC)s include pleomorphic carcinomas, giant cell carcinomas, spindle cell carcinomas, pulmonoblastomas, and carcinosarcomas. At present, there are limited reports on PSCT, and pathologists lack sufficient knowledge about it.

Patient concerns:
Here, we report a case of malignant neoplasm involving the left posterior wall of the initial tracheal segment, characterized by atypical spindle cells and a small number of high-grade squamous intraepithelial neoplasia.

Diagnosis:
Spindle-shaped cells were moderately heterotypic, with 8/10 nuclear divisions (high-magnification field), and no obvious inflammatory cell infiltration was observed in the interstitium. Squamous epithelial cells showed moderate-to-severe atypia with regional cytoplasmic transparency. Immunohistochemistry: Fusiform tumor cells expressed vimentin, epithelial markers were negative, the Ki-67 proliferation index was 40%, and epithelial markers were expressed in squamous intraepithelial neoplasia.

Interventions:
After the biopsy diagnosis was confirmed, part of the tumor was removed by tracheoscopy under general anesthesia in the respiratory department of a superior hospital. A pathological diagnosis of TSC was made and local radiotherapy was performed.

Outcomes:
As the tumor could not be completely cured, the patient experienced repeated coughing and shortness of breath and died of the disease 15 months later.

Lessons:
Pathological morphology and immunohistochemical analyses deepen our understanding of the pathological features of TSC and provide a diagnostic reference for clinicians who will encounter such cases in the future.
Severe Epstein–Barr virus encephalitis with peripheral nerve damage: A case report
Authors: Luo Aidi , Li Chang , Zhao Jing , Wu Yujuan , Fu Rong 
Published: December 2024

Rationale:
Epstein–Barr virus (EBV) is a B-lymphotropic double-stranded DNA virus. Most people infected with EBV are asymptomatic infection. Its clinical symptoms are rarely manifested as EBV encephalitis, and peripheral nerve damage is even rarer.

Patient concerns:
We report a case of a 49-year-old woman with a history of fever. The initial symptoms were numbness and weakness in the right hand, followed by slurred speech. Electromyography showed severe damage to the median nerve of the right wrist (involving sensory and motor fibers). Magnetic resonance imaging revealed multiple lesions in the bilateral cerebral hemispheres on T2 FLAIR images, and T1-enhanced images showed abnormal enhancement of the adjacent leptomeninges. Human herpesvirus 4 (EBV) has been detected in the cerebrospinal fluid using metagenomic next-generation sequencing (NGS). After antiviral treatment, the patient’s symptoms continued to worsen.

Diagnosis:
Severe EBV encephalitis complicated with peripheral nerve damage.

Interventions:
Antiviral, hormone therapy.

Outcomes:
At the patient’s condition progressed, a new infarction occurred in the right frontal lobe lesion, with repeated high fever, rapid deterioration of multiple organ function, sudden respiratory failure, cardiac arrest, and death.

Lessons:
In patients with signs of encephalitis, cerebrospinal fluid NGS should be used as early as possible to confirm the diagnosis of EBV encephalitis. Timely and accurate treatment of central nervous system infections is expected to reduce the mortality rate and improve the quality of life of patients in later stages.
Catastrophic antiphospholipid syndrome of pregnancy with acute massive cerebral infarction: A case report
Authors: Hu Xinxing , Liu Meihong 
Published: December 2024

Rationale:
Catastrophic antiphospholipid syndrome (CAPS) is the most serious type of antiphospholipid antibody syndrome (APS) and can be easily confused with other disorders, such as hemolytic uremic syndrome, disseminated intravascular coagulation and thrombocytopenia syndromes. Timely diagnosis of CAPS poses considerable challenges due to its rarity and the fact that clinicians often lack knowledge of the disease.

Patient concerns:
A 21-year-old patient was 32 weeks and 5 days pregnant when she presented to the hospital with a 7-hour history of sudden onset of left-sided limb weakness with no apparent cause. Lupus anticoagulant and/or anticardiolipin antibodies were positive. Head magnetic resonance imaging + magnetic resonance angiography + diffusion weighted imaging: right temporo-occipital insula, right basal ganglia and bilateral radial corona-hemispheric center showed multiple acute-phase cerebral infarction changes and right middle cerebral artery occlusion.

Diagnoses:
Catastrophic antiphospholipid syndrome.

Interventions:
By intracranial artery thrombectomy and anticoagulation with low-molecular heparin.

Outcomes:
The patient’s left limb muscle strength recovered to grade 5. A healthy baby boy was delivered by cesarean section. Both mother and child are safe.

Lessons:
The rarity of CAPS is such that misdiagnosis often occurs, culminating in serious complications and even death, emphasizing the need for early recognition, timely diagnosis and immediate treatment. In CAPS that improves with treatment, monitoring and prevention of recurrence is also essential.
Unveiling the mystery: Investigating the debate surrounding mitochondrial DNA copy number and Sjögren syndrome using Mendelian randomization analysis
Authors: Zhou Jie , Xu Yixin , Wang Haitao , Chen Chao , Wang Kun 
Published: December 2024

Numerous studies have investigated the relationship between mitochondrial DNA (mtDNA) copy number and Sjögren syndrome (SS). However, the conclusions remain inconclusive, with conflicting findings. The genome-wide association study summary statistics for mtDNA copy number were obtained from 2 sources: a cohort of 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the UK Biobank, and a dataset of 395,718 UK Biobank participants. Additionally, we obtained 2 sets of genome-wide association study summary statistics for SS through datasets from FinnGen and the UK Biobank, involving a total of 809,836 participants. Furthermore, we conducted a two-sample bidirectional Mendelian randomization analysis, primarily utilizing the inverse variance weighted method, complemented by 4 other validation methods, to explore the association between mtDNA copy number and SS. Following our comprehensive investigation, no discernible causal relationship was identified between mtDNA copy number and SS in either the training or validation cohorts (inverse variance weighted, P
> .05). Similarly, the reverse Mendelian randomization analysis yielded negative results (inverse variance weighted, P
> .05). Furthermore, all analyses indicated an absence of horizontal pleiotropy or heterogeneity. Our analysis revealed no causal relationship between mtDNA copy number and SS.
Blood routine test-based biomarkers is related to bone mineral density in elderly patients with chronic heart failure: A retrospective study
Authors: Chen Lan , Xu Fan , Tong Qian , Wang Guofu 
Published: December 2024

Background:
Our previous studies suggested that bone mineral density (BMD) correlated with the severity of chronic heart failure (HF) as classified by the New York Heart Association (NYHA) and that blood routine test (BRT)-based biomarkers, including hemoglobin, red blood cells (RBCs), lymphocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index, were significantly related with BMD in general population.

Objective:
This work aimed to evaluate the relationship between BRT-based biomarkers and BMD in elderly patients with chronic HF.

Methods:
It was a retrospective study. BRT and BMD were measured on the same day. Chi-square analysis and 1-way analysis of variance or the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables, respectively. Correlation analysis was performed by the Spearman correlation test.

Results:
A total of 1049 participants were enrolled. Hemoglobin, RBCs, white blood cells, neutrophils, monocytes, eosinophils, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were significantly different among different NYHA groups. The Spearman correlation test showed that lumbar vertebrae 2-4 (L2–L4) BMD was closely related to hemoglobin and RBC, and that femoral neck BMD was also significantly correlated with hemoglobin and RBC, white blood cells, neutrophils, monocytes, and platelets. Furthermore, stratified analysis in different NYHA classes demonstrated, only in NYHA class I and II groups, hemoglobin was significantly related to L2–L4 and femoral neck BMD.

Conclusion:
BRT-based biomarkers were significantly different among different NYHA groups, which deserves further investigation and application in the future.
Xuebijing and somatostatin against acute pancreatitis: A systematic review and network pharmacology
Authors: Cao Ji-Ping , Piao Xiang-Hua , Zhu Long-Xun , Feng Pan-Feng 
Published: December 2024

Background:
Acute pancreatitis (AP) is a common pancreatic disease. Xuebijing injection (XBJ) combined with somatostatin in the treatment of AP is frequently used in clinical practice. There is, however, a lack of high-quality evidence-based evidence and network pharmacology to regard the therapeutic efficacy and pharmacological mechanisms.

Purpose:
The purpose of this study is to investigate the potential therapeutic targets and pharmacological mechanism of XBJ in AP using integrating evidence-based medicine and network pharmacology.

Methods:
PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Weipu, and Wanfang databases were searched. Randomized controlled trials of XBJ combined with somatostatin (experimental group) versus somatostatin alone (control group) in the treatment of AP were collected. After extracting data from the literature that meets the inclusion criteria, and using the Cochrane Scale to evaluate the quality of the literature, we used Rev Man 5.3.0 statistical software to perform meta-analysis of the effective rate, the disappearance time of abdominal pain and bloating, the recovery of gastrointestinal motility, serum-related indicators, inflammatory factors, ventilator evacuation time, and hospitalization time. A network pharmacology is used to analyze the potential active ingredients and related crucial targets of the XBJ in the treatment of AP, and we explored key regulatory pathways and potential biomarkers related to XBJ for AP with integrated bioinformatics analysis.

Results:
It was significant that the total effective rate in the study group was higher than that in the control group (P < .05). The time of recovery of gastrointestinal motility, serum-related indicators, inflammatory factors, ventilator withdrawal time, and hospitalization time were significantly lower than that of the control group. The differences were statistically significant (P < .05). Signal transducer and activator of transcription 3, tumor protein P53, interleukin 6, tumor necrosis factor, Jun Proto-Oncogene, SRC Proto-Oncogene, Heat Shock Protein 90 Alpha Family Class A Member 1, Vascular Endothelial Growth Factor A, Epidermal Growth Factor Receptor, and Mitogen-Activated Protein Kinase 1 were identified as the key hub of the protein–protein interaction network according to an analysis of network centrality. According to the Kyoto Encyclopedia of Genes and Genomes pathway analysis, the main pathways are involved in PI3K–Akt signaling pathway, HIF-1 signaling pathway, and tumor necrosis factor signaling pathway.

Conclusions:
The effectiveness of combination therapy of XBJ and somatostatin on AP is likely to be better than somatostatin. In addition, XBJ and somatostatin synergistically treated AP through a multi-pathway network.
Long-term follow-up after acute mercury poisoning-induced pneumonitis following cinnabar heating: A rare case report
Authors: Nguyen-Dang Khoa , Dau-Nguyen Anh-Thu , Tran-Ngoc Nguyen , Duong-Minh Ngoc , Dang-Vu Thong , Nguyen-Ngoc Sang , Vu-Hoai Nam , Le-Quoc Hung 
Published: December 2024

Rationale:
Among 3 forms of mercury, elemental mercury vapor presents the highest threat due to its potential to cause acute pneumonitis. The management of acute mercury vapor poisoning remains unclear, particularly in acute lung injury. We present a case of mercury vapor poisoning resulting from the heating of cinnabar, successfully treated with high-dose corticosteroids and chelation therapy, and follow-up over 6 months.

Patient concerns:
A 47-year-old female patient was admitted to the Emergency Department due to dyspnea, chest tightness, and weakness following cinnabar heating.

Diagnoses:
Upon admission, she presented with tachypnea and respiratory failure. During the first 5 days, the respiratory failure rapidly progressed, requiring high-flow nasal cannula support, and showed no improvement with broad-spectrum intravenous (IV) antibiotics and 80 mg daily IV methylprednisolone. Total blood and urinary mercury levels were measured to confirm the diagnosis.

Interventions:
Upon confirmation of acute pneumonitis due to mercury vapor poisoning, the patient was administered high-dose methylprednisolone (500 mg IV per day) and chelation therapy, which led to subsequent improvement.

Outcomes:
Six months after discharge, the patient completely recovered, as evidenced by chest imaging and pulmonary function tests.

Lessons:
Heating elemental mercury can cause pneumonitis, leading to acute respiratory failure. A detailed history is crucial for diagnosis. High-dose methylprednisolone should be considered in patients who do not respond to lower doses. Patients should be monitored afterward to detect residual pulmonary fibrotic changes.
PLUS-M Mobility Values of Osseointegration Patients: How do Osseointegration Limb Replacement Prosthesis Users Compare to Traditional Socket Amputee Prosthesis Users?
Authors: Page Brian Joseph , Sheridan Gerard A , Greenstein Michael D , Hoellwarth Jason S , Reif Taylor J , Rozbruch S. Robert 
Published: December 2024

ABSTRACT

OBJECTIVE
The primary aim of this study was to compare osseointegration limb replacement prosthesis users (OI-LRPU) to normative published PLUS-M values for traditional socket prosthesis users (TSPU). The secondary aim was to investigate whether patient factors were predictive of PLUS-M scores.

DESIGN
Retrospective review of all patients who underwent OI maintained in a prospectively maintained registry. All patients (N = 63) were invited to complete a PLUS-M survey. 30 patients completed the survey (15 femoral OI, 15 tibial OI).

RESULTS
The OI-LRPU cohort’s composite median scores and inter-quartile ranges for the PLUS-M Raw Score, PLUS-M T-score, and PLUS-M percentile score were 57 (46-60), T-score 62.5 (51.275 – 71.4) and 89.5 (54.95 – 98.4). PLUS-M T-scores were higher in the OI-LRPU compared with the age and etiology matched literature-reported outcomes in TSPU for above-knee (p = 0.027) and below-knee (p = 0.029) amputees. Tibial OI scores were slightly higher than femur OI scores but did not reach statistical significance. PLUS-M raw (p = 0.047) and PLUS-M percentile scores (p = 0.041) were significantly improved for younger patients at the time index amputation. Regression analysis supported this finding.

CONCLUSIONS
OI-LRPU demonstrate improved functional mobility outcome scores relative to TSPU. PLUS-M functional scores were improved for younger patients at time of index amputation.
Association of First Trimester Nuchal Septations With Abnormal Pregnancy Outcomes
Authors: Duan Yuping , Guo Daoning , Huang Dan 
Published: December 2024

Abstract
This retrospective study included 311 patients who had increased nuchal translucency (NT ≥3 mm) or nuchal septations (NSs) during the first trimester from January 2018 to December 2020. These patients were divided into 3 groups: (1) patients with NT thickness between 3 and 5 mm and without NS (NT 3–5 mm group, n = 131), (2) patients with NT thickness >5 mm and without NS (NT >5 mm group, n = 105), and (3) patients with NS (NS group, n = 75). The incidence of abnormal pregnancy outcomes was 92.0% in the NS group, which was significantly higher (both P's < 0.01) compared with that in the NT 3–5 mm group (57.3%) and NT >5 mm group (75.2%). Multivariate logistic regression analysis illustrated that the sonographic evidence of NS was associated with a higher risk of abnormal pregnancy outcomes compared with NT 3–5 mm (odds ratio [OR] = 8.552; 95% confidence interval [CI]: 3.411–21.441; P < 0.01) and NT >5 mm (odds ratio [OR] = 3.636; 95% CI: 1.391–9.524; P < 0.01). After NT measurement entered the multivariate logistic regression as a continuous confounder, patients with NS were still associated with a higher risk of composite abnormal outcomes compared with those without NS (odds ratio [OR] = 4.820; 95% CI: 1.877–12.380; P < 0.01). In conclusion, the presence of NS during the first trimester was significantly associated with a high risk of abnormal pregnancy outcomes.