bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Acquired Resistance to Savolitinib, a Selective MET Inhibitor in MET-Amplified Gastric Cancer
Authors: Frigault Melanie M. , Markovets Aleksandra , Nuttall Barrett , Kim Kyoung-Mee , Park Se Hoon , Gangolli Esha A. , Mortimer Peter G.S. , Hollingsworth Simon J. , Hong Jung Yong , Kim Kyung , Kim Seung Tae , Barrett J. Carl , Lee Jeeyun 
Published: March 2020

PURPOSE Some gastric cancers harbor MET gene amplifications that can be targeted by selective MET inhibitors to achieve tumor responses, but resistance eventually develops. Savolitinib, a selective MET inhibitor, is beneficial for treating patients with MET-driven gastric cancer. Understanding the resistance mechanisms is important for optimizing postfailure treatment options. PATIENTS AND METHODS Here, we identified the mechanisms of acquired resistance to savolitinib in 3 patients with gastric cancer and MET-amplified tumors who showed a clinical response and then cancer progression. Longitudinal circulating tumor DNA (ctDNA) is useful for monitoring resistance during treatment and progression when rebiopsy cannot be performed. RESULTS Using a next-generation sequencing 100-gene panel, we identified the target mechanisms of resistance MET D1228V/N/H and Y1230C mutations or high copy number MET gene amplifications that emerge when resistance to savolitinib develops in patients with MET-amplified gastric cancer. CONCLUSION We demonstrated the utility of ctDNA in gastric cancer and confirmed this approach using baseline tumor tissue or rebiopsy.
Serum cobalt concentrations remain at low levels at a minimum of 20 years following metal-on-metal total hip arthroplasty
Authors: Waldstein Wenzel , Koller Ulrich , Springer Bernhard , Kolbitsch Paul , Brodner Wolfram , Windhager Reinhard , Lass Richard 
Published: March 2020

Aims Second-generation metal-on-metal (MoM) articulations in total hip arthroplasty (THA) were introduced in order to reduce wear-related complications. The current study reports on the serum cobalt levels and the clinical outcome at a minimum of 20 years following THA with a MoM (Metasul) or a ceramic-on-polyethylene (CoP) bearing. Methods The present study provides an update of a previously published prospective randomized controlled study, evaluating the serum cobalt levels of a consecutive cohort of 100 patients following THA with a MoM or a CoP articulation. A total of 31 patients were available for clinical and radiological follow-up examination. After exclusion of 11 patients because of other cobalt-containing implants, 20 patients (MoM (n = 11); CoP (n = 9)) with a mean age of 69 years (42 to 97) were analyzed. Serum cobalt levels were compared to serum cobalt levels five years out of surgery. Results The median cobalt concentration in the MoM group was 1.04 μg/l (interquartile range (IQR) 0.64 to 1.70) at a mean of 21 years (20 to 24) postoperatively and these values were similar (p = 0.799) to cobalt levels at five years. In the CoP control group, the median cobalt levels were below the detection limit (< 0.3 μg/l; median 0.15 μg/l, IQR 0.15 to 0.75) at 20 years. The mean Harris Hip Score was 91.4 points (61 to 100) in the MoM group and 92.8 points (63 to 100) in the CoP group. Conclusion This study represents the longest follow-up series evaluating the serum cobalt levels after 28 mm head MoM bearing THA and shows that serum cobalt concentrations remain at low levels at a mean of 21 years (20 to 24) after implantation. Cite this article: Bone Joint Res. 2020;9(3):145–150.
Cycling Performance Enhancement After Drop Jumps May Be Attributed to Postactivation Potentiation and Increased Anaerobic Capacity
Authors: de Poli Rodrigo A.B. , Boullosa Daniel A. , Malta Elvis S. , Behm David , Lopes Vithor H.F. , Barbieri Fabio A. , Zagatto Alessandro M. 
Published: March 2020

Abstract
de Poli, RAB, Boullosa, DA, Malta, ES, Behm, D, Lopes, VHF, Barbieri, FA, and Zagatto, AM. Cycling performance enhancement after drop jumps may be attributed to postactivation potentiation and increased anaerobic capacity. J Strength Cond Res 34(9): 2465–2475, 2020—The study aimed to investigate the effects of drop jumps (DJs) on supramaximal cycling performance, anaerobic capacity (AC), electromyography, and fatigue. Thirty-eight recreational cyclists participated into 3 independent studies. In study 1 (n = 14), neuromuscular fatigue was assessed with the twitch interpolation technique. In study 2 (n = 16), the AC and metabolic contributions were measured with the maximal accumulated oxygen deficit method and the sum of the glycolytic and phosphagen pathways. In study 3 (n = 8), postactivation potentiation (PAP) induced by repeated DJs was evaluated. The DJ protocol was effective for significantly improving cycling performance by +9.8 and +7.4% in studies 1 and 2, respectively (p ≤ 0.05). No differences were observed in electromyography between conditions (p = 0.70); however, the force evoked by a doublet at low (10 Hz) and high frequencies (100 Hz) declined for control (−16.4 and −23.9%) and DJ protocols (−18.6 and −26.9%) (p < 0.01). Force decline was greater in the DJ condition (p < 0.03). Anaerobic capacity and glycolytic pathway contributions were +7.7 and +9.1% higher after DJ protocol (p = 0.01). Peak force during maximal voluntary contraction (+5.6%) and doublet evoked force at 100 Hz (+5.0%) were higher after DJs. The DJ protocol induced PAP, improved supramaximal cycling performance, and increased AC despite higher peripheral fatigue.
Turbulent kinetic energy and self-sustaining tones: Experimental study of a rectangular impinging jet using high Speed 3D tomographic Particle Image Velocimetry
Authors: Assoum Hassan Hasan , Hamdi Jana , El Hassan Mouhammad , Abed-Meraim Kamel , El Kheir M. , Mrach T. , El Asmar S. , Sakout Anas 
Published: March 2020

Impinging jets are widely used in ventilation systems to improve the mixing and diffusion of airflows. When a rectangular jet hits a slotted plate, an acoustic disturbance can be generated and self-sustained tones produced. Few studies have looked at the Turbulent Kinetic Energy (TKE) produced by the aerodynamic field in such configurations and in the presence of self-sustaining tones. The aim of this work is to investigate the energy transfer between the aerodynamic and acoustic fields generated in a rectangular jet impinging on a slotted plate. The present paper methodology is based on experimental data measurements using 3D tomographic Particle Image Velocimetry (PIV) technique and microphones. It was found that the spectrum of the TKE for Re=5294 (configuration of self-sustained tones) is which is smaller than that of the acoustic signal . A negative peak of correlation is obtained between the acoustic signal and TKE for These results may lead to conclude that the acoustic cycle should be covered by the TKE period and the two signals of both fields are in opposition of phase in order to obtain an optimal configuration for energy transfer.
Implementasi Permendagri N0 113 Tahun 2014 dalam APBDesa
Authors: Pratama Athar Yaniar , Br. Sebayang Lesta Lesta Karolina 
Published: March 2020

This study aims to examine and find out the implementation of Permendagri No. 113 of 2014 in Ngesrepbalong Village, Limbangan, Kendal Regency and analyze the obstacles faced by village officials in its implementation.This study uses a qualitative approach with a case study research strategy. Data obtained through interviews and documentation studies.The results of the study show the Implementation of Permendagri No. 113 of 2014 in Ngesrepbalong Village can generally be seen from the following findings: Fund allocation is not appropriate in accordance with the provisions; There is a discrepancy between the list of program activities that have been agreed upon in the village meeting with the details of the activities contained in the RKP table; There is an RKP that does not include a discussion on the evaluation of the previous year's financial use; in the aspect of transparency, the Village Government has implemented it by informing the allocation of funds and the development of their use on information boards in the village office.
Penelitian ini bertujuan untuk mengkaji dan mengetahui implementasi Permendagri No 113 tahun 2014 di Desa Ngesrepbalong Kecamatan Limbangan Kabupaten Kendal dan menganalisis kendala yang dihadapi aparatur desa dalam pelaksanaannya.Penelitian ini menggunakan pendekatan kualitatif dengan strategi penelitian studi kasus. Data yang diperoleh melalui wawancara dan studi dokumentasi. Hasil penelitian menunjukkan Implementasi Permendagri No 113 tahun 2014 di Desa Ngesrepbalong dapat dilihat dari temuan berikut ini: Pengalokasian dana tidak tepat sesuai dengan ketentuan; Adanya ketidaksesuaian antara daftar program kegiatan yang telah disepakai dalam musyawarah desa dengan rincian kegiatan yang ada dalam tabel RKP; Terdapat RKP yang tidak mencantumkan pembahasan mengenai evaluasi penggunaan keuangan tahun sebelumnya; pada aspek trasnparansi, Pemerintah Desa telah melaksanakannya dengan menginformasikan pengalokasian dana dan perkembangan penggunaannya pada papan informasi di kantor desa.
Effectivity and Efficiency of Regional Property Management Results and Financial Performance
Authors: Thafaki Tasyaa'u Mulka 
Published: March 2020

The purpose of this research to determine the level of efficiency and results that reflect the performance and financial performance of BUMD in Semarang City, period 2014-2016. The type of data used is secondary data, using data analysis through DEA analysis and interview method. The results showed that PDAMs and RPH & BPH in 2014 still met the level, with a value of 82.4% and 62.6%. In 2015, as a whole, BUMD has achieved the value of efficiency and effectiveness. In 2016 RPH & BPH companies have not been able to reach the level of 8.1%. The level of appeal in the 2014 and 2015 BPR BKK will jointly achieve a joint achievement level of 89.5% and 93.8%. Using a comprehensive annual calculation of BUMD has reached the level of effectiveness with a value of 100%.
Tujuan penelitian ini untuk mengetahui tingkat efisiensi dan hasil yang mencerminkan kinerja dan kinerja keuangan BUMD di Kota Semarang, periode 2014-2016. Jenis data yang digunakan adalah data sekunder, menggunakan analisis data melalui analisis DEA dan metode wawancara. Hasil penelitian menunjukkan bahwa PDAM dan RPH & BPH pada tahun 2014 masih memenuhi level, dengan nilai 82,4% dan 62,6%. Pada 2015, secara keseluruhan, BUMD telah mencapai nilai efisiensi dan efektifitas. Pada 2016, perusahaan RPH & BPH belum dapat mencapai level 8,1%. Tingkat banding di BPR BKK 2014 dan 2015 akan bersama-sama mencapai tingkat pencapaian bersama sebesar 89,5% dan 93,8%. Menggunakan perhitungan tahunan BUMD yang komprehensif telah mencapai tingkat efektifitas dengan nilai 100%.
Sciarid pests (Diptera: Sciaridae) from undercover crop production in South Africa
Authors: Katumanyane Agil , Kanzi Aquillah M. , Malan Antoinette P. 
Published: March 2020

Fungus gnats (sciarids) are among the most important pests in undercover crop production. They cause direct physical damage to plant roots, transfer fungal pathogens and create entry points for soil-borne plant pathogens. In 2007, Bradysia impatiens, an important fungus gnat pest was found in association with major tree nursery beds in the Mpumalanga and KwaZulu-Natal Provinces of South Africa and was considered invasive. In this study, eight greenhouses were surveyed in the Western Cape Province and B. impatiens was found to be present in all the greenhouses. Similar to the results of the previous studies, a high haplotype diversity was identified for B. impatiens, which may indicate multiple strain introductions into South Africa. Two other fungus gnat species, Lycoriella sativae and Lycoriella ingenua – globally important sciarid pests of mushroom cultures – were identified as new from South Africa. Through a laboratory culture, the life cycle of B. impatiens was observed to be approximately 21 days at 25 °C. Females laid between 100 and 250 eggs. Possible introduction sources include contaminated vegetative material and growth media, thus there maybe need to revise the importation restrictions on these commodities. The identification of two novel species of sciarid pests that have only previously been identified in the Holarctic region could further emphasise this need. However, the recent discovery of such high sciarid diversity could also be due to only a few studies having been previously done on sciarid pests in South Africa.
Significance:

The fungus gnat species Bradysia impatiens is reported as present in several undercover crops in the Western Cape Province of South Africa, including cucumbers, tomatoes, chrysanthemums, mushrooms, blueberries and various herbs.
Lycoriella ingenua and Lycoriella sativae were also found to be present in mushroom gardens – the first report of Lycoriella from the Afro-tropical region.
The three fungus gnat species are some of the most important sciarid pests in undercover crop production worldwide. This study highlights the need for more studies on the distribution of these sciarids and possible invasion history.

Open data set:
https://www.ncbi.nlm.nih.gov/popset?DbFrom=nuccore&Cmd=Link&LinkName=nuccore_popset&IdsFromResult=1654675097
Effect of Deepening Finacial Sector on Income Gap in Six Asia Countries 2012-2016
Authors: Dominica Lizzy , Shabrina Zeisha , Octavianie Hanna , Septiani Sindy 
Published: March 2020

The financial sector has an important role in increasing a country’s economic growth, but the income gap is one of the main problems in economic growth in various countries. The financial sector has a strong influence on economic development, poverty alleviation and economic stability. This study aims to determine the effect of financial sector deepening on income inequality by using panel data from six countries, namely Malaysia, Indonesia, Philippines, Singapore, China and Korea which are divided into two groups, namely lower middle income countries, namely Indonesia and the Philippines and upper middle / high income, namely Malaysia, Singapore, China and Korea in 2012-2016. By using the Panel Least Squares analysis technique, this study found results that were upper middle / high income; bank assets, money supply, stock traded have a positive effect; lending to the private sector; domestic money bank assets, private sector debt securities and stock market capitalization have a negative effect. Whereas in lower middle income countries; bank assets, money suply, stock market capitalization have a negative effect; stock traded has a positive effect; however, lending to the private sector, domestic money bank assets, government debt and private sector debt does not affect the income gap.

Keywords: Financial Deepening, Income Gap, Asia
The Effects of Ethics Institutionalization on Organizational Citizenship Behavior: The Mediating Effects of Organizational Commitment and Moderating Effects of Psychological Empowerment
Authors: Destika Sandakila Eka , Satrya Aryana 
Published: March 2020

Many of organization implement code of conduct as an explicit guidance to help employees knowing the standard of ethics from management“s viewpoints, with the aim to gain productivity achieving organization“s goal. The purpose of this paper is to examine the influence of ethics institutionalization on organizational citizenship behavior and to analyze the role of organizational commitment in mediating the impact of ethics institutionalization on organizational citizenship behavior with psychological empowerment as a moderator in one of State Institution in Indonesia. This research will use a quantitative approach with online survey method to 250 respondents which were determined by purposive sampling method. Respondents come from employees of XYZ State Institution who already work at the institution for minimum 2 years. Based on analysis from preliminary literature, it can be concluded that all variables used in this research are valid, reliable and having correlation with each others. This research is still on progress and result will be discussed further.

Keywords: Institutionalization of Ethics, Explicit Ethics Institutionalization, Implicit Ethics Institutionalization, Organizational Commitment, Psychological Empowerment, Organizational Citizenship Behavior
Harmonization of Economics and Local Culture in the Frame of Suistainable Technological Innovation (Case Study of Ketoprak Atmodjo Budoyo in Kudur Village Pati Regency)
Authors: Citra Dewi Lita , Maftukhah Ida 
Published: March 2020

Indonesia is a superpower country in the field of culture (The United Nations Educational Scientific and Cultural-UNESCO). Culture can be way for the governments to improve the economy and reduce the gap in the industrial revolution 4.0. Undang-Undang nomor 5 tahun 2017 about promoting culture provides a platform for cultural development. In 2017 there were 141,732 people or equivalent with 11.38% belonging to the poor population, its means that there is 393,817 per capita per month in the poverty line in Pati. One of things that can help the economy is from the cultural sector, one of which is through the Ketoprak Cilik in Kudur village became the most influential Ketoprak Cilik in Pati, even this Ketoprak of Dalang Bowo Asmoro’s care had scented Pati district in an international art performance in Borobudur (www.kabarkotapati.com). This Kotoprak Cilik show still requires innovation related to industrial management, such as training and schedule management (Bowo Asmoro, 2019). Ketoprak Cilik consist of elementary and junior high school students. The training is held every Saturday and Monday at Kudur Village Hall. The Kudur Village office is equipped with a broad set of gamelan and stage areas that are useful for practicing Ketoprak Cilik performances. Ketopra Cilik as a Cultural is used to instill the spirit of love of local culture to the younger generation, this is a concrete step that encourages local people to jointly build the character of the young generation through culture. The results of the small ketoprak staging will be put into the village treasury to later help the community’s economy. With this can encourage the emergence of cultural economic collaboration in the village of Kudur-Pati. This study uses qualitative methods with interviews and references from various trusted sources. This paper examines more deeply how culture plays a role in improving the economy of the community and forming the character of Indonesia’s young generation.
Keywords: Technology, Ketoprak Cilik, Economics
Uterine Compression Sutures in Controlling Postpartum Haemorrhage: A Narrative Review
Authors: Moleiro Maria Lúcia , Braga Jorge , Machado Maria João , Guedes-Martins Luís 
Published: March 2020

Introduction: Postpartum haemorrhage is still the main cause of maternal morbidity and mortality. Many treatments are available, but they may threaten fertility potential. As a uterine sparing procedure, we aimed to review uterine compression sutures in order to better understand when they should represent an appropriate option.Material and Methods: A comprehensive search in MEDLINE and PubMed databases including the terms ‘postpartum haemorrhage’ and ‘uterine compression sutures’ was performed. Results were revised and articles reviewing or presenting case reports of uterine compression sutures to treat postpartum haemorrhage were included.Results: The first description of uterine compression sutures to control postpartum haemorrhage was published in 1997, by B-Lynch et al. After this publication, many others have reported successful management of postpartum haemorrhage with different suturing techniques. Most of them describe success rates above 75% and the possibility of fertility preservation, with cases of uneventful pregnancy after uterine compression sutures already published. Complications associated with each technique are rare.Discussion: Reports of use of uterine compression sutures include small series of cases or even single case reports which limits the quality of existing evidence to support one technique over another. Nevertheless, uterine compression sutures are recognized as an effective surgical conservative strategy to control postpartum haemorrhage due to uterine atony and its use is recommended, if possible, prior to hysterectomy.Conclusion: Uterine compression sutures are effective, safe and simple to perform in an emergent situation and preserve fertility potential in cases of postpartum haemorrhage.
Abordagem do Doente com Psoríase pela Medicina Geral e Familiar: Algoritmo de Referenciação e Gestão Partilhada com a Dermatologia
Authors: Torres Tiago , Henrique Martinha , Oliveira Hugo , Rodrigues Madalena , Ferreira Paulo , Morais Paulo , Alves Sérgio , Lopes Tiago Castro , Cernadas Rui 
Published: March 2020

Introdução: A implementação de modelos capazes de melhorar a referenciação, por forma a garantir a qualidade e precocidade do diagnóstico, o melhor tratamento e seguimento do doente psoriático é fundamental.Material e Métodos: Um painel de médicos de Medicina Geral e Familiar e Dermatologia discutiu e criou um algoritmo de referenciação simples, eficaz e célere de doentes com psoríase.Resultados: O algoritmo proposto inicia-se quando o clínico de Medicina Geral e Familiar suspeita de psoríase. Caso haja dúvidas no diagnóstico, o doente deve ser referenciado para a dermatologia. No caso de um diagnóstico confirmado, compete ao clínico de Medicina Geral e Familiar avaliar a gravidade e perfil de respondedor do doente, rastrear comorbilidades e a possibilidade de artrite psoriática. Se a psoríase for ligeira, deverão ser iniciados tratamentos tópicos, sendo que, se não houver melhoria clínica ou ocorrer agravamento da doença, o doente deverá ser referenciado para a dermatologia. Se a psoríase for considerada moderada a grave, em localizações de elevado impacto, ou em idade pediátrica, o doente deverá ser referenciado para a dermatologia. Para que o seguimento e tratamento destes doentes seja partilhado, é fundamental que o médico de Medicina Geral e Familiar tenha o conhecimento necessário sobre os tratamentos sistémicos que o doente está a fazer e os seus efeitos adversos.Discussão e Conclusão: Apenas uma gestão partilhada do doente psoriático poderá tornar possível o melhor tratamento e seguimento destes doentes, a utilização mais racional dos recursos médicos disponíveis, proporcionando ao doente a melhor qualidade devida possível.
Preliminary research on the demand for face aesthetic medicine among medical students
Authors: Tomaszewski Mateusz , Matthews‑Kozanecka Maja , Zbitkowski Sebastian 
Published: March 2020

Introduction. Treatments in the field of aesthetic face medicine are becoming more and more popular, although awareness of the needs of their use is still very low.Aim. Presenting knowledge about facial aesthetics and estimating the needs for their application among students of dentistry at the Medical University in Poznań.Material and Methods. 60 surveys (46 women and 14 men) were included in the statistical analysis addressed to Polish- and English‑speaking students of the 3rd, 4th and 5th year of Medical and Dental studies at the Medical University of Poznań in 2019.Results. Most respondents (88%) believe that facial aesthetic medicine should be performed and it is worth starting their use at the age of 25–30 (the most common answer — 28%). 10% of the respondents used facial aesthetic medicine, and 38% facial cosmetology.Discussion. Studies by other authors indicate that the largest group of clients are women between 20–30 years old with a stable financial situation, which corresponds to the results of the survey. However, this differs from the results of the PTMEiAA research from 2017, which prove that aesthetic medicine clinics are most often visited by people aged 41 to 50 years. Customers are more willing to opt for minimally invasive procedures, which was also confirmed by the tests.Conclusions. The demand for facial aesthetics among medical students of the Medical University in Poznań, regardless of the respondents' country of origin, is relatively low.