bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glider Sampling Simulations in High-Resolution Ocean Models
Authors: Steinberg Jacob M. , Eriksen Charles C. 
Published: April 2020

AbstractIdealized simulations of autonomous underwater glider sampling along sawtooth vertical–horizontal paths are carried out in two high-resolution ocean numerical models to explore the accuracy of isopycnal vertical displacement and geostrophic velocity profile estimates. The effects of glider flight speed, sampling pattern geometry, and measurement noise on velocity profile accuracy are explored to interpret recent full-ocean-depth Deepglider observations and provide sampling recommendations for glider missions. The average magnitude of velocity error profiles, defined as the difference between simulated glider-sampled geostrophic velocity profile estimates and model velocity profiles averaged over the spatial and temporal extent of corresponding simulated glider paths, is less than 0.02 m s−1 over most of the water column. This accuracy and the accuracy of glider geostrophic shear profile estimates are dependent on the ratio of mesoscale eddy to internal wave velocity amplitude. Projection of normal modes onto full-depth vertical profiles of model and simulated glider isopycnal vertical displacement and geostrophic velocity demonstrates that gliders are capable of resolving barotropic and baroclinic structure through at least the eighth baroclinic mode.
The Performance of a Revised Simplified Arakawa–Schubert (SAS) Convection Scheme in the Medium-Range Forecasts of the Korean Integrated Model (KIM)
Authors: Han Ji-Young , Hong Song-You , Kwon Young Cheol 
Published: April 2020

Abstract
The Korea Institute of Atmospheric Prediction Systems (KIAPS) has developed a new global numerical weather prediction model, named the Korean Integrated Model (KIM). This paper presents the cumulus parameterization scheme (CPS) used in KIM, which originates from the simplified Arakawa–Schubert (SAS) convection scheme in the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) and has undergone numerous modifications in an effort to improve the medium-range forecast skill for precipitation and large-scale fields. The modifications include the following: 1) the threshold of the trigger condition is updated to consider the dependency on the environmental relative humidity (RH) averaged over the subcloud layer in order to suppress the trigger of convection in dry low-level environments; 2) the entrainment rate is modified to increase the sensitivity to environmental humidity, so that enhanced entrainment under lower RH conditions leads to a greater decrease in the strength of the convection that develops in drier environments; 3) the autoconversion parameter from cloud condensate to convective precipitation is changed to have a temperature dependency above the freezing level; 4) the closure is modified to consider rapidly varying boundary layer forcing; 5) the effect of the convection-induced pressure gradient force in convective momentum transport is enhanced in the upper part of the convective updrafts; and 6) scale awareness that enables a mass-flux CPS to work seamlessly at various grid sizes across gray-zone resolutions is addressed. The evaluation of medium-range forecasts with the KIM CPS reveals higher forecast skill, especially over the tropics, in comparison with its original version.
Influence of exfoliated graphite filler size on the electrical, thermal, and mechanical polymer properties
Authors: Khammassi Sabrine , Tarfaoui Mostapha 
Published: April 2020

Exfoliated graphite has attracted significant research interest, especially with respect to composite manufacturing as a sheet shape material for enhancing their mechanical, electrical, and thermal properties with cost-effectiveness. It has been proved in different researches that size of nanoparticles plays a vital role and has significant effect. So, in this study, exfoliated graphite with three different sizes i.e. 50 mesh (large dimension), 100 mesh (medium size), and 150 mesh (small size) are integrated in epoxy to examine their effect on the mechanical/electrical/thermal performance of the material and for each mesh size range of 0.5 wt.% to 20 wt.% is utilized. These three systems of reinforced epoxy with different size of exfoliated graphite are evaluated in DIGIMAT simulation software by investigating their electrical, thermal and mechanical properties. The numerical results showed that integration of exfoliated graphite in neat epoxy drastically improved its electrical, thermal, and mechanical performance. In addition, it was found that the use of the bigger size was more effective on the performance of the material, which is probably because of the enhanced connectivity between the structuring sheets. Moreover, a gradual increase in properties is observed with increasing the percentage of exfoliated graphite content in each system. This numerical study was developed in accordance to validate the experimental study conducted by Debelak et al. This study further provides the evidence of the appropriateness of the DIGIMAT simulation as an investigational load in relevant research.
Screw Removal Can Resolve Unexplained Anterior Pain Without Recurrence of Shoulder Instability After Open Latarjet Procedures
Authors: Godenèche Arnaud , Merlini Lorenzo , Roulet Steven , Le Chatelier Morgane , Delgrande Damien , Saffarini Mo , Michelet Aude , Métais Pierre 
Published: April 2020

Background: Anterior shoulder instability can be successfully treated using Latarjet procedures, although a small proportion of patients report unexplained pain. Purpose/Hypothesis: The purpose was to report the prevalence and characteristics of patients with unexplained pain without recurrent instability after open Latarjet procedures and to determine whether screw removal can alleviate pain. The hypothesis was that unexplained pain without recurrent instability might be due to soft tissue impingements against the screw heads and that the removal of screws would alleviate or reduce pain. Study Design: Case series; Level of evidence, 4. Methods: We retrospectively reviewed the clinical and radiographic records of 461 consecutive shoulders treated by open Latarjet procedures for anterior instability between 2002 and 2014. Unexplained anterior pain was present in 21 shoulders (4.6%) and treated by screw removal at 29 ± 37 months (mean ± SD). Postoperative assessment at >12 months after screw removal included complications, visual analog scale for pain (pVAS), subjective shoulder value, Rowe score, Walch-Duplay score, and ranges of motion. The study cohort comprised the shoulders of 20 patients (9 women, 11 men) aged 25 ± 6 years (median, 25 years; range, 16-34 years) at screw removal and involved the dominant arm in 13 (62%) shoulders. Results: Screw removal alleviated pain completely in 14 shoulders (67%; pVAS improvement, 6.4 ± 1.8; median, 6; range, 3-8) and reduced pain in the remaining 7 (33%; pVAS improvement, 2.4 ± 1.4; median, 2; range, 1-5). At 38 ± 23 months after screw removal, 2 recurrences of instability unrelated to screw removal occurred. The subjective shoulder value was 79% ± 22% (median, 90%; range, 0%-95%); Rowe score, 85 ± 20 (median, 95; range, 30-100); and Walch-Duplay score, 82 ± 19 (median, 85; range, 25-100). Mobility improved in active forward elevation (171°± 14°), external rotation with the elbow at the side (61°± 12°), and external rotation with the arm at 90° of abduction (67°± 13°) and especially in internal rotation, with only 2 shoulders (10%) limited to T12 spine segment. Conclusion: The present findings confirm that unexplained anterior pain after Latarjet procedures can be related to the screws used to fix bone blocks, which can safely be alleviated or reduced by screw removal.
Sample size calculation and re-estimation based on the prevalence in a single-arm confirmatory diagnostic accuracy study
Authors: Stark Maria , Zapf Antonia 
Published: April 2020

Introduction In a confirmatory diagnostic accuracy study, sensitivity and specificity are considered as co-primary endpoints. For the sample size calculation, the prevalence of the target population must be taken into account to obtain a representative sample. In this context, a general problem arises. With a low or high prevalence, the study may be overpowered in one subpopulation. One further issue is the correct pre-specification of the true prevalence. With an incorrect assumption about the prevalence, an over- or underestimated sample size will result. Methods To obtain the desired power independent of the prevalence, a method for an optimal sample size calculation for the comparison of a diagnostic experimental test with a prespecified minimum sensitivity and specificity is proposed. To face the problem of an incorrectly pre-specified prevalence, a blinded one-time re-estimation design of the sample size based on the prevalence and a blinded repeated re-estimation design of the sample size based on the prevalence are evaluated by a simulation study. Both designs are compared to a fixed design and additionally among each other. Results The type I error rates of both blinded re-estimation designs are not inflated. Their empirical overall power equals the desired theoretical power and both designs offer unbiased estimates of the prevalence. The repeated re-estimation design reveals no advantages concerning the mean squared error of the re-estimated prevalence or sample size compared to the one-time re-estimation design. The appropriate size of the internal pilot study in the one-time re-estimation design is 50% of the initially calculated sample size. Conclusions A one-time re-estimation design of the prevalence based on the optimal sample size calculation is recommended in single-arm diagnostic accuracy studies.
Human herpesvirus 6 encephalitis in a patient treated with everolimus for renal cell carcinoma
Authors: Kokkali Stefania , Oddou Isabelle , Gantzer Justine , Fitsiori Aikaterini 
Published: April 2020

Introduction Everolimus is a mammalian target of rapamycin inhibitor and is approved as second-line treatment or beyond for renal cell carcinoma. We report a case of a 75-year-old male treated with everolimus for metastatic renal cell carcinoma, after sunitinib treatment, who was diagnosed with human herpesvirus 6 encephalitis. Case report After 39 months of everolimus, 10 mg per day, our patient was admitted with fever, consciousness disorders and a partial epileptic crisis. Laboratory tests revealed lymphopenia (170 lymphocytes/mm3), and polymerase chain reaction in cerebrospinal fluid was positive for human herpesvirus 6. Brain magnetic resonance imaging study demonstrated hippocampal abnormality and a pontine lesion. Management and outcome The patient stopped everolimus treatment indefinitely. He received ganciclovir initially intravenously, with a rapid clinical improvement, as well as polyvalent immunoglobulins were given to correct hypogammaglobulinemia. Two months later, antiviral therapy was switched to oral ganciclovir, which was never stopped. A new lumbar puncture was performed one month after the initiation of antiviral treatment, which did not reveal human herpesvirus 6 DNA anymore. Discussion Human herpesvirus 6 encephalitis is more common in hematopoietic stem cell transplant recipients and HIV patients. This is the first case probably associated to everolimus treatment. In contrast to most patients diagnosed with this infection, who either die or develop neurologic sequelae, our patient almost fully recovered two months later.
Surgical exploration without resection in pancreatic and periampullary tumors: Report from a national database
Authors: Sahlström Emil , Nilsson Johan , Tingstedt Bobby , Bergenfeldt Magnus , Andersson Roland , Andersson Bodil 
Published: April 2020

Background and objective: Pancreatic and periampullary cancers are sometimes found to have a too advanced disease during surgery to allow resection. The aim was to describe characteristics, treatment, outcome, and time trends for patients that were planned for pancreatic surgery but found unresectable during surgery. Methods: Data from the Swedish National Pancreatic and Periampullary Cancer Registry were used. All patients registered between January 2010 and August 2018 were included. The patient cohort was divided in two halves based on year of diagnosis. Results: In total, 12,377 patients were included in the registry and finally 4568 patients were scheduled for surgery. During surgical exploration, 3879 (84.9%) patients underwent pancreatic resection, 658 (14.4%) patients were found unresectable, and 31 (0.7%) had no pancreatic resection due to other reasons (e.g. benign lesion, comorbidity). More patients underwent surgical exploration and resection during the second time period, but exploration without resection was unchanged (15.7% vs 13.7%; p = 0.062). Survival rates were lower among the unresectable patients with pancreatic and periampullary tumors compared to the resectable patients, including 30-day mortality (n = 17 (3.5%) vs n = 39 (1.6%), p = 0.004) and 90-day mortality (n = 72 (15.0%) vs n = 70 (2.8%), p < 0.001). Palliative surgery became less common during the second half of the time period (p < 0.001). Conclusions: Unresectability is associated with an unfavorable prognosis. The frequency did not decrease during the study period, but palliative surgical procedures became less common.
Long-term follow-up after surgical repair of abdominal rectus diastasis: A Prospective Randomized Study
Authors: Swedenhammar Ebba , Strigård Karin , Emanuelsson Peter , Gunnarsson Ulf , stark Birgit 
Published: April 2020

Background: Abdominal rectus diastasis can lead to functional disability. There is no consensus regarding treatment. This was a prospective study on patients randomized to surgery using either Quill self-retaining sutures or retromuscular mesh for abdominal rectus diastasis repair. The primary aim of the study was to compare long-term recurrence after surgery. Secondary aims were abdominal muscle strength, pain, and quality of life. Methods: A total of 57 patients were eligible and 52 were investigated. A routine 1-year follow-up ruled out any patient with recurrence and this was followed up by clinical examination for recurrence and assessment of the secondary outcomes a median of 5 years (3.8–6.5 years) after surgery. Quality of life was assessed using the Short Form-36 questionnaire. Pain related to activity was evaluated using the Ventral Hernia Pain Questionnaire. Results: No recurrence of abdominal rectus diastasis was found. Significant improvements were seen between index surgery and long-term follow-up in all domains of Short Form-36. There were no significant differences in quality of life or self-reported muscle strength between the two surgical groups. Long-term pain remained unchanged compared to that at the 1-year follow-up. “Pain this week” had decreased significantly at long-term follow-up compared to prior to surgery (mesh p = 0.009, Quill p = 0.003). Conclusions: No recurrence of abdominal rectus diastasis appeared. There was no difference in quality of life or long-term pain between the two surgical groups. Implantation of retromuscular mesh entails more extensive surgery implying potentially higher risk for complications. This leads us to recommend reconstruction with double-row self-retaining sutures for the repair of abdominal rectus diastasis in patients with functional disability.
Perioperative stroke-related mortality after non-cardiovascular, non-neurological procedures: A retrospective risk factor evaluation of common surgical comorbidities
Authors: Reinert Nathan J , Patel Bansri M , Al-Robaidi Khaled , Gao Xiaotian , Fabio Anthony , Jadhav Ashutosh , Muluk Visala S , Esper Stephen A , Zuckerbraun Brian S , Thirumala Parthasarathy D 
Published: April 2020

Background Perioperative stroke-related mortality in the non-cardiovascular, non-neurological surgery population is an uncommon, yet devastating outcome. A combination of emboli and hypoperfusion may cause large vessel occlusions leading to perioperative strokes and mortality. Identifying independent risk factors for perioperative stroke-related mortality may enhance risk-stratification algorithms and preventative therapies. Objectives This study utilised cause-of-death data to determine independent risk scores for common surgical comorbidities that may lead to perioperative stroke-related mortality, including atrial fibrillation and asymptomatic carotid stenosis. Methods This retrospective, IRB-exempt, case–control study evaluated non-cardiovascular, non-neurological surgical patients in a claims-based database. ICD-10-CM and ICD-9-CM codes identified cause of death and comorbidity incidences, respectively. A multivariate regression analysis then established adjusted independent risk scores of each comorbidity in relation to perioperative stroke-related mortality. Results Patients with atrial fibrillation were more likely (1.7 aOR, 95% CI (1.1, 2.8) p = 0.02) to die from perioperative stroke-related mortality than from other causes. No association was found with asymptomatic carotid stenosis. Further, in-hospital strokes (25.9 aOR, 95% CI (16.0, 41.8) p < 0.001) or diabetes (1.8 aOR, 95% CI (1.1, 2.9) p = 0.02) may increase perioperative stroke-related mortality risk. Conclusions Atrial fibrillation, diabetes and in-hospital strokes may be independent risk factors for perioperative stroke-related mortality in the non-cardiovascular, non-neurological surgery population.
The effect of gum chewing on postoperative ileus in open colorectal surgery patients: A review
Authors: Sammut Roberta , Trapani Josef , Deguara Justin , Ravasi Valeria 
Published: April 2020

Background Postoperative ileus is a common complication of abdominal surgery, leading to prolonged hospital stay and associated costs. Gum chewing may be a safe, cheap intervention to reduce postoperative ileus. Methods The aim was to investigate the effect of gum chewing on postoperative ileus in open colorectal surgery patients. A literature search was conducted between December 2018 and March 2019 on CINAHL, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews, MEDLINE, Academic Search Complete, PubMed, Scopus and Google Scholar. The keywords used included ‘ileus’, ‘chewing gum’, ‘mastication’ and ‘sham feeding’. Papers had to include adults undergoing open colorectal surgery. The studies were appraised using Critical Appraisal Skills Programme tools and the results summarised using a narrative review. Results A total of three systematic reviews and three randomised controlled trials were included in the study. The studies show a significant to highly significant effect of gum chewing on postoperative ileus-related outcomes. The trials however in general utilised a weak design. Conclusions Gum chewing decreases postoperative ileus following colorectal surgery. More robust trials are required to confirm these findings. Due to the low risk of harm and cost of using gum chewing, its use is recommended even in the interim.
Considerations for multi-centre conditioned pain modulation (CPM) research; an investigation of the inter-rater reliability, level of agreement and confounders for the Achilles tendon and Triceps Surae
Authors: Murphy Myles , Gibson William , Chivers Paola , Docking Sean , Rio Ebonie 
Published: April 2020

Objective: This study aimed to investigate the inter-rater reliability of the conditioned pain modulation (CPM) effect. Methods: The reliability between two examiners assessing the CPM effect via pressure pain thresholds and induced using the cold pressor test of 28 healthy volunteers at the mid-portion Achilles tendon (AT) and Triceps Surae musculotendinous junction was performed. Reliability was calculated using intraclass correlation coefficient (ICC). Confounders were assessed using multivariable generalised estimating equations (GEEs). Bias in the level of agreement was assumed if the confidence intervals (CIs) of the mean difference in Bland–Altman plots did not cross the line of equality. Results: The inter-rater reliability of the CPM effect was poor to moderate in the AT (ICC 95% CI = 0.00–0.66) and Triceps Surae (ICC 95% CI = 0.00–0.69). However, when accounting for confounders within the GEE, there were no differences between testers and Bland–Altman plots reported good agreement between testers. Habitual completion of running-related physical activity was a confounder for both the AT parallel-paradigm (p = 0.017) and sequential-paradigm (p = 0.029). Testing order was a confounder for the AT (p = 0.023) and Triceps Surae (p = 0.014) parallel-paradigm. Conclusion: This study suggests the CPM effect may be site specific (i.e. differences between the AT and Triceps Surae exist). In addition, differences in the reliability between examiners are likely due to the influence of confounders and not examiner technique and therefore appropriate analysis should be used in research investigating the CPM effect.
An Improved Rosin Transfer Process for the Reduction of Residue Particles for Graphene
Authors: Shahzad Kashif , Jia Kunpeng , Zhao Chao , Yan Xiangyu , Yadong Zhang , Usman Muhammad , Luo Jun 
Published: April 2020

AbstractIn this work, an improved rosin transfer process is initiated. An anisole coating is introduced based on the rosin transfer process to reduce the residue particles on the surface of transferred graphene. Rosin/graphene and anisole/rosin/graphene samples are handled without baking and with baking at different temperatures, i.e., 100 °C, 150 °C, and 200 °C. Atomic force microscopy (AFM) and Raman spectroscopy are employed to characterize the surface properties of transferred graphene. The removal of the protective rosin layer and anisole/rosin layers without baking is found to be more effective and beneficial compared to the conventional PMMA transfer process. Furthermore, better results in terms of reduced surface roughness and residue particles are accomplished by introducing anisole in the improved rosin transfer process. Uniform and low sheet resistance (Rsh) is also observed across transferred graphene using this improved process.
Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells
Authors: Cho Whajung , Choe Jongseon 
Published: April 2020

AbstractBackgroundProstaglandin E2 (PGE2) is an endogenous lipid mediator of inflammation. Its production is regulated by the rate-limiting upstream enzyme cyclooxygenase-2 (COX-2). We have recently demonstrated that the major cell type expressing COX-2 in the germinal center is follicular dendritic cell (FDC). In this study, to elucidate the molecular mechanism of PGE2in COX-2 production, we asked whether mitogen-activated protein kinases ERK and p38 might regulate COX-2 expression.ResultsFDC-like cells were used to analyze the phosphorylation kinetics of ERK and p38 and the impact of genetic knockdown. PGE2stimulation gave rise to a rapid increase of p38 but not ERK phosphorylation. In contrast, IL-1β induced phosphorylation of both MAPKs. Knockdown of p38 resulted in a marked suppression of COX-2 expression induced by either PGE2or IL-1β. ERK knockdown did not significantly affect the effect of PGE2and IL-1β on COX-2 induction. The differential results of p38 and ERK siRNA transfection were reproduced in the production of prostaglandins and in experiments performed with pharmacologic inhibitors.ConclusionsOur data indicate that p38 is essentially required for PGE2to induce COX-2 expression in FDC-like cells. The current study helps to expand our understanding of the biological function of FDC at the molecular level and provides a potential rationale for the pharmacologic or genetic approaches to regulate p38 MAPK in the treatment of various inflammatory disorders.