bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of femoral versus radial access in neuroendovascular procedures with propensity adjustment
Authors: Catapano Joshua S , Fredrickson Vance L , Fujii Tatsuhiro , Cole Tyler S , Koester Stefan W , Baranoski Jacob F , Cavalcanti Daniel D , Wilkinson D Andrew , Majmundar Neil , Lang Michael J , Lawton Michael T , Ducruet Andrew F , Albuquerque Felipe C 
Published: December 2019

BackgroundThe transradial artery (TRA) approach for neuroendovascular procedures continues to gain popularity, but neurointerventionalists still lag behind interventional cardiologists in the adoption of a TRA-first approach. This study compares the complications and efficiency of the TRA approach to the standard transfemoral artery (TFA) approach at our institution during our initial phase of adopting a TRA-first approach.MethodsA retrospective analysis was performed on all consecutive neuroangiographic procedures performed at a large cerebrovascular center from October 1, 2018 to June 30, 2019. The standard TFA approach was compared with TRA access, with the primary outcome of complications analyzed via a propensity-adjusted analysis.ResultsA total of 1050 consecutive procedures were performed on 877 patients during this 9-month period; 206 (20%) procedures were performed via TRA and 844 (80%) via TFA. The overall complication rate was significantly higher with the TFA procedures than with the TRA procedures (7% (60/844) vs 2% (4/206), respectively; p=0.003). A propensity-adjusted analysis showed that the TFA approach was a significant risk factor for a complication (OR 3.6, 95% CI 1.3 to 10.2, p=0.01). However, the propensity analysis showed that fluoroscopy times were on average 4 min less for TFA procedures than for TRA procedures (p=0.003).ConclusionThe TRA approach for neuroendovascular procedures appears to be safer than the TFA approach. Although a steep learning curve is initially encountered when adopting the TRA approach, the transition to a TRA-first practice can be performed safely for neurointerventional procedures and may reduce complications.
The effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study
Authors: Workman Craig D. , Kindred John H. , Boles Ponto Laura L. , Kamholz John , Rudroff Thorsten 
Published: December 2019

This exploratory pilot study investigated the effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on cerebral glucose metabolism in people with multiple sclerosis (PwMS). Compared with nonusers, THC users had hypermetabolism of 3 regions (p < 0.039, d >1.17) in left temporal areas, while CBD users had hypometabolism of 5 regions (p < 0.032, d > 1.31) in left temporal areas. This study highlights the need to discriminate between THC and CBD in future cannabis studies. Novelty Chronic THC and CBD use had disparate effects on cerebral glucose metabolism in PwMS.
Quantum charged spinning massless particles in 2 + 1 dimensions
Authors: Morales Ivan , Neves Bruno , Oporto Zui , Piguet Olivier 
Published: December 2019

AbstractMotivated by the conduction properties of graphene discovered and studied in the last decades, we consider the quantum dynamics of a massless, charged, spin 1/2 relativistic particle in three dimensional space-time, in the presence of an electrostatic field in various configurations such as step or barrier potentials and generalizations of them. The field is taken as parallel to the y coordinate axis and vanishing outside of a band parallel to the x axis. The classical theory is reviewed, together with its canonical quantization leading to the Dirac equation for a 2-component spinor. Stationary solutions are numerically found for each of the field configurations considered, from which we calculate the mean quantum trajectories of the particle and compare them with the corresponding classical trajectories, the latter showing a classical version of the Klein phenomenon. Transmission and reflection probabilities are also calculated, confirming the Klein phenomenon.
Quasinormal modes of massive scalar field with nonminimal coupling in higher-dimensional de Sitter black hole with single rotation
Authors: Gwak Bogeun 
Published: December 2019

AbstractWe analytically investigate the quasinormal modes of the massive scalar field with a nonminimal coupling in the higher-dimensional de Sitter black hole with a single rotation. According to the separated scalar field equation, the boundary conditions of quasinormal modes are well constructed at the outer and cosmological horizons. Then, under near-extremal conditions, where the outer horizon closes to the cosmological horizon, the quasinormal frequencies are obtained and generalized to universal form in the higher-dimensional spacetime. Here, the real part of the frequency includes the scalar field contents, and its imaginary part only depends on the surface gravity at the outer horizon of the black hole.
The preparation and electrochemical performance of Mo6S8 as cathode materials for magnesium ion batteries
Authors: Wang Zekun , Huang Jianfeng , Li Jiayin 
Published: December 2019

In this work, we reported a Chevrel phase [Formula: see text], which was synthesized by a molten salt approach, and its electrochemical performance as a cathode material for rechargeable magnesium batteries. The phase composition and micromorphology of the product were measured and analyzed by X-ray diffraction, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The Chevrel phase sulfide delivered an excellent specific capacity of 91 mAh g[Formula: see text] at a current density of 0.2 C after 70 cycles. Its excellent reversible capacity, rate performance and cycle stability demonstrate the feasibility of the Chevrel phase [Formula: see text] materials for future rechargeable magnesium batteries.
Photodegradation of bisphenol A in nonferrous metal mining wastes
Authors: Wu Junyao , Zhang Yiyue , Yao Jun , Gao Wei 
Published: December 2019

Metal mining wastes have caused severe environmental pollution. Bisphenol A (BPA) is a typical pollutant that comes from flotation reagent. This work studied the efficiency of direct photodegradation of BPA under multi-wavelength medium-pressure ultraviolet light (MP-UV). The effects of photo-exposure time, initial pH, BPA concentration, and existence of anions, cations, [Formula: see text] and [Formula: see text] on the BPA degradation behavior were studied. The results showed that MP-UV could effectively degrade BPA. The reaction follows the apparent first-order kinetic model, with a mineralization rate of 27.6% and accumulation of acidic intermediates. The degradation rate decreases with increasing initial concentration but the total amount of degraded BPA increased. With increasing pH, the degradation rate increases, which is related to the morphology of BPA. The promotion degree of BPA photodegradation follows the order of [Formula: see text], while the inhibition degree follows the order of [Formula: see text]. Furthermore, the half-life of [Formula: see text] system was 11.55 min; and [Formula: see text] is the main oxidative active substance in the system. The half-life of [Formula: see text] system was 12.65 min; and [Formula: see text] is the main oxidative active substance in the system.
ASSESSMENT OF EFFECTIVE BLOOD CONCENTRATION READINGS FROM CLINICAL DATA ON PATIENTS WITH HEART FAILURE DISEASES AFTER DIGOXIN INTAKE: A PROJECTION BASED ON THE INVERSE PROBLEM ALGORITHM
Authors: LIN YA-HUI , HSIAO KAI-YU , CHANG YU-TENG , KITTIPAYAK SAMRIT , PAN LUNG-FA , PAN LUNG-KWANG 
Published: December 2019

In this study, a projection of effective blood concentration (EBC) readings of digoxin is made using the inverse problem algorithm based on clinical data for patients with heart failure diseases. Seven factors, including body surface area (BSA), blood urine nitrogen (BUN), creatinine, sodium (Na), potassium (K), magnesium (Mg) ion readings, and mean arterial pressure (MAP) were compiled with nonlinear regression fit to develop a projection function having 29 terms obtained from an inverse problem algorithm via the default function run in STATISTICA. Accordingly, data collected from the clinical 168 heart failure patients were normalized to be included in same domain range ([Formula: see text]1 to +1), and then calculated by the specific algorithm to optimize the numerical solution to evaluate EBC readings of digoxin. The evaluated first-order regression fit owned an optimal loss function ([Formula: see text]) coupled with correlation coefficient [Formula: see text] = 0.892 and variance of 89.20%. Furthermore, 45 patients having similar clinical syndromes were also adopted to verify the projection and implied with high agreement. The BUN factor dominated the projection and defined as the most significant coefficient in the analysis, and K ion, MAP, BSA, and Mg ion factors exhibited minor contributions to the projection. The repeated trials to lower number of factors from seven to a smaller number (namely 6, 5, 4, 3, 2, and 1) for simplifying method but resulting with unaccepted outcomes, with high loss function values and low linearity. However, the algorithm held its accuracy to handle the verified data that were out of the original bounds. The proposed algorithm demonstrated a useful analysis to handle the drug administration in pharmaceutical field.
BUILDING EFFICIENT COMPUTATIONAL CELLULAR AUTOMATA MODELS OF COMPLEX SYSTEMS: BACKGROUND, APPLICATIONS, RESULTS, SOFTWARE, AND PATHOLOGIES
Authors: KROC JIŘÍ , JIMÉNEZ-MORALES FRANCISCO , GUISADO J. L. , LEMOS MARÍA CARMEN , TKÁČ JAKUB 
Published: December 2019

Cellular automaton models of complex systems (CSs) are gaining greater popularity; simultaneously, they have proven the capability to solve real scientific and engineering applications. To enable everybody a quick penetration into the core of this type of modeling, three real applications of cellular automaton models, including selected open source software codes, are studied: laser dynamics, dynamic recrystallization (DRX) and surface catalytic reactions.The paper is written in a way that it enables any researcher to reach the cutting edge knowledge of the design principles of cellular automata (CA) models of the observed phenomena in any scientific field. The whole sequence of design steps is demonstrated: definition of the model using topology and local (transition) rule of a cellular automaton, achieved results, comparison to real experiments, calibration, pathological observations, flow diagrams, software, and discussions. Additionally, the whole paper demonstrates the extreme expressiveness and flexibility of massively parallel computational approaches compared to other computational approaches. The paper consists of the introductory parts that are explaining CSs, self-organization and emergence, entropy, and CA. This allows readers to realize that there is a large variability in definitions and solutions of this class of models.
Thai dance exercises benefited functional mobility and fall rates among community-dwelling older individuals
Authors: Kaewjoho Chonticha , Mato Lugkana , Thaweewannakij Thiwabhorn , Nakmareong Saowanee , Phadungkit Supaporn , Gaogasigam Chitanongk , Amatachaya Sugalya 
Published: December 2019

Background: With dramatic increase in the number of older individuals, special efforts have been made to promote the levels of independence and reduce fall rates among these individuals. Objective: To investigate the effects of Thai dance exercises over 6 weeks on functional mobility and fall rates in community-dwelling older individuals. Methods: Sixty-one community-dwelling older adults were interviewed and assessed for their demographics and fall data during 6 months prior to participation in the study. Then they completed the quasi-experimental Thai dance exercise program for 50 minutes[Formula: see text]day, 3 days[Formula: see text]week over 6 weeks. Their functional mobility relating to levels of independence and safety were assessed prior to training, at 3-week and 6-week training. After completing the program at 6 weeks, participants were prospectively monitored for fall data over 6 months. Results: Participants improved their functional mobility significantly after 3- and 6-week training [Formula: see text]. The number of faller individuals obviously decreased from 35% [Formula: see text] prior to training to only 8% [Formula: see text] after training [Formula: see text]. Conclusion: The current findings further extend benefits of Thai dance as an alternative musical exercise program to promote levels of independence and safety among community-dwelling older adults.
AN OPTION THEORETIC APPROACH TO MARKET EFFICIENCY
Authors: BHATTACHARYA RAJEEV R. 
Published: December 2019

I use five separate measures of deviation from Put-Call Parity of options on a stock without splits or dividends as separate negative measures for market efficiency. I rely upon the theory of trading volume as a function of short sales costs, etc., and that of market efficiency as a function of trading volume, etc. derived by Bhattacharya (2019). I use Three-Stage Least Squares (3SLS) to estimate this structural system, separately for Nasdaq and non-Nasdaq U.S. stocks. I find, contrary to much previous theoretical and empirical work, that the impact of short sales costs & constraints on market efficiency is not significantly negative and that the impact of trading volume on market efficiency is not significantly positive, and my results are robust to various econometric specifications and financial economic assumptions.
Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites: a randomized controlled trial
Authors: Israelsen Mads , Dahl Emilie Kristine , Madsen Bjørn Stæhr , Wiese Signe , Bendtsen Flemming , Møller Søren , Fialla Annette Dam , Jensen Boye L. , Krag Aleksander 
Published: December 2019

Acute kidney injury and hepatorenal syndrome (HRS) are frequent complications in patients with cirrhosis and ascites. First-line treatment is terlipressin, which reverses HRS in ~40% of patients but also lowers cardiac output (CO). We aimed to investigate whether reversing the cardio-suppressive effect of terlipressin with the β-adrenoceptor agonist dobutamine would increase CO and thereby increase the glomerular filtration rate (GFR). We randomized 25 patients with cirrhosis, ascites, and impaired renal function (2:2:1): group A received terlipressin followed by the addition of dobutamine; group B received dobutamine and terlipressin as monotherapies; and group C received placebo. Renal and cardiac functions were assessed during 8 clearance periods of 30 min, and concentrations of vasoactive hormones were measured. Dobutamine as a monotherapy increased CO (1.03 L/min, P < 0.01) but had no significant effects on GFR. Renin ( P < 0.05), angiotensin II ( P < 0.005), and aldosterone ( P < 0.05) increased after dobutamine infusion. Terlipressin as a monotherapy improved GFR (18.9 mL·min−1·m−2, P = 0.005) and mean arterial pressure (MAP) (14 mmHg, P = 0.001) but reduced CO (−0.92 L/min, P < 0.005) and renin ( P < .005). A combined treatment of dobutamine and terlipressin had a positive effect on CO (1.19 L/min, P < 0.05) and increased renin ( P < 0.005), angiotensin II ( P < 0.005), and aldosterone ( P < 0.05), but it had no significant effects on MAP or GFR. Dobutamine reversed the cardio-suppressive effect of terlipressin in cirrhosis, ascites, and impaired renal function. However, dobutamine reduced peripheral vascular resistance, activated renin-angiotensin-aldosterone system, and did not improve GFR compared with terlipressin as a monotherapy. Therefore, dobutamine cannot be recommended in cirrhosis and ascites. NEW & NOTEWORTHY This study shows that the cardio-suppressive effects of the vasopressin receptor agonist terlipressin can be reversed by dobutamine. This is a novel observation in patients with decompensated cirrhosis. Furthermore, we show that dobutamine reduced the peripheral vascular resistance and activated the renin-angiotensin system, whereas renal function was not further improved by terlipressin alone.
A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition
Authors: Kitchen Philip , Lee Ka Ying , Clark Danielle , Lau Nikki , Lertsuwan Jomnarong , Sawasdichai Anyaporn , Satayavivad Jutamaad , Oltean Sebastian , Afford Simon , Gaston Kevin , Jayaraman Padma-Sheela 
Published: December 2019

Abstract

Aberrant Notch and Wnt signaling are known drivers of cholangiocarcinoma (CCA), but the underlying factors that initiate and maintain these pathways are not known. Here, we show that the proline-rich homeodomain protein/hematopoietically expressed homeobox (PRH/HHEX) transcription factor forms a positive transcriptional feedback loop with Notch3 that is critical in CCA. PRH/HHEX expression is elevated in CCA, and depletion of PRH reduces CCA tumor growth in a xenograft model. Overexpression of PRH in primary human biliary epithelial cells is sufficient to increase cell proliferation and produce an invasive phenotype. Interrogation of the gene networks regulated by PRH and Notch3 reveals that unlike Notch3, PRH directly activates canonical Wnt signaling. These data indicate that hyperactivation of Notch and Wnt signaling is independent of the underlying mutational landscape and has a common origin in dysregulation of PRH. Moreover, they suggest new therapeutic options based on the dependence of specific Wnt, Notch, and CDK4/6 inhibitors on PRH activity.

Significance:
The PRH/HHEX transcription factor is an oncogenic driver in cholangiocarcinoma that confers sensitivity to CDK4/6 inhibitors.
Financial Burdens and Barriers to Care Among Nonelderly Adults With Heart Disease: 2010–2015
Authors: Bernard Didem , Fang Zhengyi 
Published: December 2019

Background
We examined the prevalence of high burdens and barriers to care among adults with heart disease treatment.

Methods and Results

The participants were aged 18 to 64 years from the Medical Expenditure Panel Survey–Household Component (MEPS‐HC) for 2010–2015.
High burden
is out‐of‐pocket spending on care and insurance premiums >20% of income.
Barriers to care
are forgoing and delaying care for financial reasons. Logistic regressions were used to estimate the odds of having high burdens and barriers. Adults treated for heart disease have odds ratios (ORs) of 2.18 (95%
CI
, 1.91–2.50) for having high burden, 2.51 (95%
CI
, 2.23–2.83) for forgoing care, and 3.57 (95%
CI
, 3.8–4.13) for delaying care compared with adults without any chronic condition. Among adults treated for heart disease compared with adults with private group coverage, ORs for having high burdens were significantly lower among those with public insurance (
OR
: 0.17; 95%
CI
, 0.10–0.26) or the uninsured (
OR
: 0.58; 95%
CI
, 0.36–0.92) and higher among those with private nongroup insurance (
OR
: 5.30; 95%
CI
, 3.26–8.61). Compared with adults with private group coverage, ORs for delaying care were 2.07 (95%
CI
, 1.37–3.12) for those with public insurance, 2.64; 95% CI, 1.70–4.10) for those without insurance, and 2.16 (95%
CI
, 1.24–3.76) for those with private nongroup insurance.

Conclusions
Public insurance provides protection against high burdens but not against forgoing or delaying care. Future research should investigate whether and to what extent barriers to care are associated with worse health outcomes and higher costs in the long term.
Behavioral Impediments to Valuing Annuities: Complexity and Choice Bracketing
Authors: Brown Jeffrey R. , Kapteyn Arie , Luttmer Erzo F. P. , Mitchell Olivia S. , Samek Anya 
Published: December 2019

Abstract
This paper examines two behavioral factors that diminish people's ability to value a lifetime income stream or annuity, drawing on a randomized experiment with about 4,000 adults in a U.S. nationally representative sample. We find that increasing the complexity of the annuity choice reduces respondents' ability to value the annuity, measured by the difference between the sell and buy values they assign to the annuity. When we limit narrow choice bracketing by inducing people to think first about how quickly or slowly to spend down assets in retirement, their ability to value an annuity increases.
A 10-Year Follow-Up of a Randomized Prospective Study of 2 Treatments for Chronic Rhinosinusitis Without Nasal Polyps and Investigation of the Impact of Gastroeosophageal Reflux Disease in the Resistance to Treatment
Authors: Lechien Jerome R. , Debie Gersende , Mahillon Virginie , Thill Marie-Paule , Rodriguez Alexandra , Horoi Mihaela , Kampouridis Stelianos , Muls Vinciane , Saussez Sven 
Published: December 2019

Objectives: To compare the 2 long-term medical strategies in chronic rhinosinusitis without nasal polyps (CRSnNP) and to identify the role of gastroesophageal reflux disease (GERD) and Helicobacter pylori as factors of treatment failure. Material and Methods: Fifty-seven patients with CRSnNP were randomized into 2 therapeutic groups. The first group was treated with 4 weeks of amoxicillin/clavulanate and a short course of oral steroids. The second group received 8 weeks of clarithromycin. Sinonasal Outcome Test-20 (SNOT-20) and Lund and Mackay scores were assessed at baseline and after treatment, and GERD Health-Related Quality of Life (GERD-HRQL) questionnaire was evaluated in all patients. Patients with a GERD-HRQL score >8 received esogastroscopy and H pylori detection. Patients were followed during a 10-year period for clinical course and GERD evolution. The 10-year evolution of patients was described in terms of recurrence, medical, and surgical treatments. Results: Thirty-seven patients completed the study; SNOT-20 and Lund and Mackay scores similarly improved in both groups. Amoxicillin/clavulanate group had significantly more adverse reactions than the clarithromycin group (P = .03). After the therapeutic course, 35% (amoxicillin/clavulanate) and 41% (clarithromycin) of patients needed functional endoscopic sinus surgery (FESS). During the long-term follow-up, 54% (amoxicillin/clavulanate) and 40% (clarithromycin) of patients had late CRSnNP recurrence; FESS was performed in less than 15% of cases of recurrence. Gastroesophageal reflux disease complaint’s severity was associated with late recurrence of CRSnNP. Conclusion: Amoxicillin/clavulanate and clarithromycin would be competitive treatments for CRSnNP. Gastroesophageal reflux disease seems to be a negative factor for treatment response and recurrence.