bluuebunny/crossref_metadata_2025_split huggingface dataset:
A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival
Authors: Massett Matthew E , Monaghan Laura , Patterson Shaun , Mannion Niamh , Bunschoten Roderick P , Hoose Alex , Marmiroli Sandra , Liskamp Robert MJ , Jørgensen Heather G , Vetrie David , Michie Alison M , Huang Xu 
Published: October 2020

AbstractEpigenomic dysregulation is a common pathological feature in human hematological malignancies. H3K9me3 emerges as an important epigenomic marker in acute myeloid leukemia (AML). Its associated methyltransferases, such as SETDB1, suppress AML leukemogenesis, whilst H3K9me3 demethylases KDM4C is required for mixed lineage leukemia rearranged AML. However, the specific role and molecular mechanism of action of another member of KDM4 family, KDM4A has not previously been clearly defined. In this study, we delineated and functionally validated the epigenomic network regulated by KDM4A. We show that selective loss of KDM4A is sufficient to induce apoptosis in a broad spectrum of human AML cells. This detrimental phenotype results from a global accumulation of H3K9me3 and H3K27me3 at KDM4A targeted genomic loci thereby causing down-regulation of aKDM4A-PAF1controlled transcriptional program essential for leukemogenesis, distinct from that of KDM4C. From this regulatory network, we further extracted aKDM4A-9gene signature enriched with leukemia stem cell activity; theKDM4A-9score alone or in combination with the knownLSC17 score, effectively stratifies high-risk AML patients. Together, these results establish the essential and unique role of KDM4A for AML self-renewal and survival, supporting further investigation of KDM4A and its targets as a potential therapeutic vulnerability in AML.
Binding of Ca2+-Independent C2 Domains to Lipid Membranes: a Multi-Scale Molecular Dynamics Study
Authors: Larsen Andreas Haahr , Sansom Mark S.P. 
Published: October 2020

AbstractC2 domains facilitate protein-lipid interaction in cellular recognition and signalling processes. They possess a β-sandwich structure, with either type I or type II topology. C2 domains can interact with anionic lipid bilayers in either a Ca2+-dependent or a Ca2+-independent manner. The mechanism of recognition of anionic lipids by Ca2+-independent C2 domains is incompletely understood. We have used molecular dynamics (MD) simulations to explore the membrane interactions of six Ca2+– independent C2 domains, from KIBRA, PI3KC2α, RIM2, PTEN, SHIP2, and Smurf2. In coarse grained MD simulations these C2 domains bound to lipid bilayers, forming transient interactions with zwitterionic (phosphatidylcholine, PC) bilayers compared to long lived interactions with anionic bilayers also containing either phosphatidylserine (PS) or PS and phosphatidylinositol bisphosphate (PIP2). Type I C2 domains bound non-canonically via the front, back or side of the β sandwich, whereas type II C2 domains bound canonically, via the top loops (as is typically the case for Ca2+-dependent C2 domains). C2 domains interacted strongly (up to 120 kJ/mol) with membranes containing PIP2 causing the bound anionic lipids to clustered around the protein. The C2 domains bound less strongly to anionic membranes without PIP2 (<50 kJ/mol), and most weakly to neutral membranes (<33 kJ/mol). Productive binding modes were identified and further analysed in atomistic simulations. For PTEN and SHIP2, CG simulations were also performed of the intact enzymes (i.e. phosphatase domain plus C2 domain) with PIP2-contating bilayers and the roles of the two domains in membrane localization were compared. From a methodological perspective, these studies establish a multiscale simulation protocol for studying membrane binding/recognition proteins, capable of revealing binding modes alongside details of lipid binding affinity and specificity.
Toward the implementation of a multi-component framework in a density-based flow solver for handling chemically reacting flows
Authors: Kalkote Nikhil , Assam Ashwani , Eswaran Vinayak 
Published: October 2020

Purpose
The purpose of this study is to present and demonstrate a numerical method for solving chemically reacting flows. These are important for energy conversion devices, which rely on chemical reactions as their operational mechanism, with heat generated from the combustion of the fuel, often gases, being converted to work.

Design/methodology/approach
The numerical study of such flows requires the set of Navier-Stokes equations to be extended to include multiple species and the chemical reactions between them. The numerical method implemented in this study also accounts for changes in the material properties because of temperature variations and the process to handle steep spatial fronts and stiff source terms without incurring any numerical instabilities. An all-speed numerical framework is used through simple low-dissipation advection upwind splitting (SLAU) convective scheme, and it has been extended in a multi-component species framework on the in-house density-based flow solver. The capability of solving turbulent combustion is also implemented using the Eddy Dissipation Concept (EDC) framework and the recent k-kl turbulence model.

Findings
The numerical implementation has been demonstrated for several stiff problems in laminar and turbulent combustion. The laminar combustion results are compared from the corresponding results from the Cantera library, and the turbulent combustion computations are found to be consistent with the experimental results.

Originality/value
This paper has extended the single gas density-based framework to handle multi-component gaseous mixtures. This paper has demonstrated the capability of the numerical framework for solving non-reacting/reacting laminar and turbulent flow problems. The all-speed SLAU convective scheme has been extended in the multi-component species framework, and the turbulent model k-kl is used for turbulent combustion, which has not been done previously. While the former method provides the capability of solving for low-speed flows using the density-based method, the later is a length-scale-based method that includes scale-adaptive simulation characteristics in the turbulence modeling. The SLAU scheme has proven to work well for unsteady flows while the k-kL model works well in non-stationary turbulent flows. As both these flow features are commonly found in industrially important reacting flows, the convection scheme and the turbulence model together will enhance the numerical predictions of such flows.
The need for innovation in deathcare leadership
Authors: Entress Rebecca M. , Tyler Jenna , Zavattaro Staci M. , Sadiq Abdul-Akeem 
Published: October 2020

PurposeThe purpose of this viewpoint essay is to examine deathcare leadership during the COVID-19 pandemic and recommend innovations to employ a more human-centric approach.Design/methodology/approachThis viewpoint essay uses scholarly and popular literature to explore deathcare practices during the ongoing COVID-19 pandemic and to identify limitations of existing mass fatality management policies.FindingsDeathcare leadership in the USA lacks a human-centric approach. Rationalistic mass fatality management during COVID-19 left families struggling with grief and mourning because many burial rituals could not take place. This essay suggests a humanistic approach to death management through leadership innovations as a remedy to this problem. Such leadership innovations can improve responses to deathcare during this ongoing pandemic and future public health emergencies.Originality/valueThis essay offers practical improvements to make deathcare more human-centric.
Robotic mirror therapy system for lower limb rehabilitation
Authors: Cheng Gaoxin , Xu Linsen , Xu Jiajun , Liu Jinfu , Shi Jia , Chen Shouqi , Liu Lei , Liang Xingcan , Liu Yang 
Published: October 2020

Purpose
This paper aims to develop a robotic mirror therapy system for lower limb rehabilitation, which is applicable for different patients with individual movement disability levels.

Design/methodology/approach
This paper puts forward a novel system that includes a four-degree-of-freedom sitting/lying lower limb rehabilitation robot and a wireless motion data acquisition system based on mirror therapy principle. The magnetorheological (MR) actuators are designed and manufactured, whose characteristics are detected theoretically and experimentally. The passive training control strategy is proposed, and the trajectory tracking experiments verify its feasibility. Also, the active training controller that is adapt to the human motor ability is designed and evaluated by the comparison experiments.

Findings
The MR actuators produce continuously variable and compliant torque for robotic joints by adjusting excitation current. The reference limb joint position data collected by the wireless motion data acquisition system can be used as the motion trajectory of the robot to drive the affected limb. The passive training strategy based on proportional-integral control proves to have great trajectory tracking performance through experiments. In the active training mode, by comparing the real-time parameters adjustment in two phases, it is certified that the proposed fuzzy-based regulated impedance controller can adjust assistance torque according to the motor ability of the affected limb.

Originality/value
The system developed in this paper fulfills the needs of robot-assisted mirror therapy for hemiplegic patients.
“Understanding my story”: young person involvement in formulation
Authors: McKeown Annette , Martin Aisling , Kennedy Patrick J. , Wilson Amy 
Published: October 2020

PurposeThe SECURE STAIRS framework has promoted young person involvement as a key feature of innovative service provision. In the North East of England, Secure Children’s Homes (SCHs) have pioneered young person involvement in team formulation. Young people have also led on the development of formulation materials through a young person involvement project. Young people’s attendance at team formulation meetings has become embedded. These service developments have also begun to expand across broader SCHs, Secure Training Centres (STCs) and Young Offender Institutions (YOIs) and reflect the national impact of such pioneering developments. There is a notable lack of research examining the impact of young person involvement in formulation. The purpose of this study is to elucidate this area.Design/methodology/approachBetween April and August 2019, there were 86 staff attendances at formulation meetings where young people were present across two SCHs in the North East of England.FindingsPaired samplest-tests indicated staff-reported significant post-formulation improvements across all domains measured including knowledge [t(85) = 11.38,p< 0.001]; confidence working with the young person [t(85) = 5.87,p< 0.001]; motivation [t(85) = 3.58,p< 0.001]; understanding [t(85) = 9.03,p< 0.001]; and satisfaction with the treatment plan [t(85) = 8.63,p< 0.001].Research limitations/implicationsImplications of findings are discussed and further developments outlined.Practical implicationsYoung people attending team formulation is a new and evolving area, and to the best of the authors’ knowledge, there is no existing research evaluating this area. The current findings suggest that staff knowledge, motivation, confidence and satisfaction with the treatment plan is improved following attendance at team formulation where the young person is present and actively participating. Young people’s participation and involvement is central to planning, developing and progressing meaningful provision within children and young people secure provision.Social implicationsInvolving children and young people in decision-making, service development and evaluation are also key components of ensuring the voice of young people is central in our minds. It also supports empowering the young people we work with. Young people and their journey should always be at the heart of what we do.Originality/valueYoung people attending team formulation is a new and evolving area, and to the best of the authors’ knowledge, there is no existing research evaluating this area. This is the first study of its type evaluating formulation directions within the SECURE STAIRS framework.
Intra-family dynamics and succession planning in family businesses in South Africa: the daughter as a potential successor
Authors: Urban Boris , Nonkwelo Ruth Palesa 
Published: October 2020

PurposeLiterature considers the succession process to be successful when both the continuity of the business and harmony within the family are preserved. This study empirically investigates intra-family dynamics with regard to daughters as potential successors in family businesses.Design/methodology/approachThe study takes place in South Africa where family businesses represent a significant amount of all listed businesses on the Johannesburg Stock Exchange. A structured survey instrument is used to collect primary data from family businesses in South Africa. The study hypotheses are statistically tested using regression analyses.FindingsResults highlight the importance of the business context (BC), intra-family cohesion (IFC), intra-family adaptability (IFA) as well as the parent-daughter relationship (PDR) in successful daughter succession planning (SP). An important insight which emerges from the findings is the extent to which a harmonious business environment is conducive in accommodating the daughter as a successor to the business.Practical implicationsFamily business owners need to be aware of the often conflicting pressures that daughters face as potential successors. Evidence-based and fit for purpose to the South African family BC processes and directives must be formulated that guide the implementation of SP. The provision of training specifically focused on gender bias issues and women empowerment programmes in family business is recommended.Originality/valueInvestigating theoretical and practical problems related to daughters in SP in South Africa is important considering that firms in African countries in general tend to be poorly managed.
Non-tariff barriers removal in the Brazilian coffee industry
Authors: Mendes Krisley , Luchine André 
Published: October 2020

Purpose
This study aims to identify and classified non-tariff measures (NTMs) on Brazilian imports of robusta coffee beans, calculated a tariff-equivalent of non-tariff barriers (NTBs) and assessed the effects of removing NTBs from upstream and downstream domestic instant coffee supply chain.

Design/methodology/approach
The analysis uses documentary research to identify NTMs and the price-wedge method is applied to estimate a tariff-equivalent. The effects of suppressing the tariff-equivalent were evaluated using a partial equilibrium model with constant elasticity of substitution (Armington, 1969) and by incorporating vertical integration and uncertainty (Hallren and Opanasets, 2018).

Findings
The results show that NTMs seemingly hinder the entrance of coffee beans into the domestic market. The tariff-equivalent was estimated at 13.61%. Suppressing it reveals that the share of domestic coffee beans used to produce domestic instant coffee falls 0.21 p.p. while the share of domestic instant coffee consumed by the international trade rises 8.60 p.p.

Originality/value
What makes this paper original is that this paper investigated the effects of NTMs in a developing country, namely, Brazil. Although Brazil is one of the largest agricultural producers in the world, it has not appeared in literature in this type of analysis until now. Furthermore, it contributes to the literature on using existing techniques to investigate the impact of NTM removal on individual products in a specific country, in contrast to more recent papers that discuss using multi-country and multi-product data sets at the HTS-6 level. Thus, this paper demonstrates how a case study approach can be useful in quantifying policy changes.
Fiscal and monetary response to the COVID-19 pandemic in India
Authors: Jose Justina , Mishra Priyanka , Pathak Rahul 
Published: October 2020

PurposeThis article examines the preliminary impact of the Sars-CoV-2 pandemic on India's economic and budgetary landscape – the most affected developing country from the first wave of the pandemic. It also includes a discussion of the monetary and fiscal responses adopted and the challenges faced in formulating the response to the pandemic.Design/methodology/approachUsing high-frequency economic and fiscal indicators, this article evaluates the economic impact of the pandemic on the Indian economy. Further, it uses data from government sources and news to highlight the measures adopted at the national and subnational level in response to the pandemic.FindingsThe difficult economic conditions prior to the pandemic limited the fiscal space available to the government. As a result, the national and subnational governments have been cautious of accumulating excessive debt and have primarily responded with liquidity-enhancing measures, in addition to some fiscal measures for the most vulnerable. Overdependence on consumption taxes has led to unprecedented revenue shortfalls prompting the exploration of new avenues for revenue generation and implementation of austerity measures – some of which may be counterproductive in the long run.Originality/valueThe paper highlights the policy response of the largest democracy that has been hit hard by the pandemic. It also highlights various institutional and resource constraints that influenced the policies adopted. India's experience in responding to the virus could provide lessons for other developing countries.
Measuring the effect of land degradation and environmental changes on agricultural production in Somalia with two structural breaks
Authors: Mohamed Abdinur Ali , Nageye Ahmed Ibrahim 
Published: October 2020

PurposeThe purpose of this study is to measure the effect of land degradation and the environmental changes on agricultural productivity in Somalia, as well as the other factors that affect crop production in Somalia.Design/methodology/approachCobb-Douglas production function assumes crop production as a dependent variable and land degradation, labor, capital, fertilizer and climate change as the explanatory variables. In this study time-series data (1962–2017) collected from the Food and Agriculture Organization and World Development Indicators were used. The unit root of the data was examined using Ng-Perron and the Lee-Strazicich methods to explore the unit root property of the breaks. Structural breaks are observed using the Chow test, and the long-run relationship between the variables is examined using Gregory and Hanssen's approach.FindingsThis study found that land degradation and climate change have a negative relationship with agriculture production in Somalia. Land degradation leads to the decline in agricultural production as the loss of one hectare of land due the depletion causes agriculture production of Somalia to fall by about five percent. Climate changes and warming of the environment lead to the reduction of agriculture production. One degree Celsius rise in the temperature leads to a three percent decline in agricultural production. Capital contributes immensely to agricultural production as one unit of additional capital raises production by seven percent. The contribution of labor to agricultural production is limited because of land contractionPractical implicationsLand degradation is a significant contributor to the decline of agricultural production. As land degradation continues to worsen, rural poverty increases, which in turn causes the rural migration and the social conflict. The government should develop land improvement programs such as increasing market orientation of the farmers, encourage private sector engagement in agribusiness and establish a regulatory framework of the land uses.Originality/valueThis study examines the structure of the time-series and specifies the break periods to determine when and where significant and sudden changes occurred within land degradation and agricultural production. The study employs advanced econometric methods, namely, Ng-Perron method and the Lee-Strazicich method to test the unit root property of the breaks. It also examines the long-run relationship between the variables using Gregory and Hanssen's approach.
Organizational memorialization: spatial history and legitimation as chiasms
Authors: de Vaujany François-Xavier , Vaast Emmanuelle , Clegg Stewart R. , Aroles Jeremy 
Published: October 2020

PurposeThe purpose of this paper is to understand how historical materialities might play a contemporary role in legitimation processes through the memorialization of history and its reproduction in the here-and-now of organizations and organizing.Design/methodology/approachThe authors briefly review the existing management and organization studies (MOS) literature on legitimacy, space and history; engage with the work of Merleau-Ponty to explore how organizational legitimacy is managed in time and space; and use the case of two Parisian universities to illustrate the main arguments of the paper.FindingsThe paper develops a history-based phenomenological perspective on legitimation processes constitutive of four possibilities identified by means of chiasms: heterotopic spatial legacy, thin spatial legacy, institutionalized spatial legacy and organizational spatial legacy.Research limitations/implicationsThe authors discuss the implications of this research for the neo-institutional literature on organizational legitimacy, research on organizational space and the field of management history.Originality/valueThis paper takes inspiration from the work of Merleau-Ponty on chiasms to conceptualize how the temporal layers of space and place that organizations inhabit and inherit (which we call “spatial legacies”), in the process of legitimation, evoke a sensible tenor.