bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Utility of Cardiopulmonary Exercise Testing in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Authors: Scheel Paul J. , Florido Roberta , Hsu Steven , Murray Brittney , Tichnell Crystal , James Cynthia A. , Agafonova Julia , Tandri Harikrishna , Judge Daniel P. , Russell Stuart D. , Tedford Ryan J. , Calkins Hugh , Gilotra Nisha A. 
Published: February 2020

Background

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (
ARVC
/D) is characterized by high arrhythmic burden and progressive heart failure, which can prompt referral for heart transplantation. Cardiopulmonary exercise testing (
CPET
) has an established role in risk stratification for advanced heart failure therapies, but has not been described in
ARVC
/D. This study sought to determine the safety and prognostic utility of
CPET
in patients with
ARVC
/D.

Methods and Results

Using the Johns Hopkins
ARVC
/D Registry, we examined patients with
ARVC
/D undergoing
CPET
. Baseline characteristics and transplant‐free survival were compared on the basis of peak oxygen consumption (pVO2) (≤14 or >14 mL/kg per minute) and ventilatory efficiency (Ve/
VCO
2
slope ≤34 or >34). Thirty‐eight patients underwent 50
CPET
s. There were no sustained arrhythmic events. Twenty‐nine patients achieved a maximal test. Patients with pVO2 ≤14 mL/kg per minute were more often men (
P
=0.042) compared with patients with pVO2 >14 mL/kg per minute. Patients with Ve/
VCO
2
slope >34 tended to have more moderate/severe right ventricular dilation (7/9 [78%] versus 10/26 [38%];
P
=0.060) and clinical heart failure (8/9 [89%] versus 13/26 [50%];
P
=0.056) compared with patients with Ve/
VCO
2
slope ≤34. Patients who underwent heart transplantation were more likely to have clinical heart failure (10/10 [100%] versus 13/28 [46%];
P
=0.003). Patients with Ve/
VCO
2
slope >34 had worse transplant‐free survival compared with patients with Ve/
VCO
2
slope ≤34 (n=35; hazard ratio, 6.57 [95%
CI
, 1.28–33.72]; log‐rank
P
=0.010), whereas transplant‐free survival was similar on the basis of pVO2 groups (n=29; hazard ratio, 3.38 [95%
CI
, 0.75–15.19]; log‐rank
P
=0.092).

Conclusions

CPET
is safe to perform in patients with
ARVC
/D. Ve/
VCO
2
slope may be used for risk stratification and guide referral for heart transplantation in
ARVC
/D.
Dependence of Probabilistic Quantitative Precipitation Forecast Performance on Typhoon Characteristics and Forecast Track Error in Taiwan
Authors: Teng Hsu-Feng , Done James M. , Lee Cheng-Shang , Kuo Ying-Hwa 
Published: February 2020

AbstractThis study investigates the probabilistic quantitative precipitation forecast (PQPF) performance of typhoons that affected Taiwan during 2011–16. In this period, a total of 19 typhoons with a land warning issued by the Central Weather Bureau (CWB) are analyzed. The PQPF is calculated using the ensemble precipitation forecast data from the Taiwan Cooperative Precipitation Ensemble Forecast Experiment (TAPEX), and the verification data, verification thresholds, and typhoon characteristics are obtained from the CWB. The overall PQPF performance of TAPEX has an acceptable reliability and discrimination ability, and the higher probability error is distributed at the mountainous area of Taiwan. The PQPF performance is significantly influenced by typhoon characteristics (e.g., typhoon tracks, sizes, and forward speeds). The PQPFs for westward-moving, large, or slow typhoons have higher reliability and discrimination ability, and lower-probability error than those for northward-moving, small, or fast typhoons, except for similar reliability between fast and slow typhoons. Because northward-moving or small typhoons have larger forecast track error, and their PQPF performance is sensitive to the accuracy of the forecast track, a higher probability error occurs than that for westward-moving or large typhoons. Furthermore, because there is no difference in track error between fast and slow typhoons, the larger track spread for slow typhoons increases the rainfall forecast spread and reduces the probability error. The orientation of Taiwan’s topography and the topographic effect also influence and increase the distribution and value of probability error for northward-moving, small, or fast typhoons. In summary, forecast track characteristics are influenced by typhoon characteristics and further affect the PQPF performance.
Gender, Racial Threat, and Perceived Risk in an Urban University Setting
Authors: Jacobsen Shannon K. , Miller Jody , Bhardwaj Ntasha 
Published: February 2020

Objectives: We provide new insights about the role of gender, race, and place in perceived risk and fear of crime and discuss the possible boundaries of the shadow of sexual assault thesis, which attributes women’s higher levels of fear to their underlying fear of rape across a variety of ecological contexts. Method: Analyses are based on data from in-depth qualitative interviews with 34 undergraduates attending a diverse urban university in a highly disadvantaged community in the northeast. Purposive and theoretical sampling strategies were used, and thematic saturation was achieved. Results: We find striking gender similarities in students’ perceptions of risk and fear of crime in this particular context. Specifically, both women and men drew on their perceptions of disorder in the community when defining the threat of victimization, which they believed was robbery committed by the city’s African American male residents. Conclusions: The gendered shadow of sexual assault was surprisingly absent from students’ discussions, suggesting that it may not be as universal across context as previous research suggests. We argue that microlevel contexts and methodological factors may shape the shadow’s presence, nature, and strength in gendered fear and perceived risk.
Palliative care: not only for treating symptoms: a case report
Authors: Pallotti Maria Caterina , Ricci Marianna , Rossi Romina , Cecconetto Lorenzo , Barone Domenico , Maltoni Marco 
Published: February 2020

Introduction: Palliative care (PC) aims to treat symptoms independently of the disease. In many medical disciplines, including oncology, there is an emphasis on personalizing treatment, identifying the most effective therapeutic option by studying the genetic heritage of the patient and the molecular characteristics of the disease. PC, on the other hand, encompasses the overall (physical and spiritual) well-being of the patient and his or her caregivers. The increasing use of early PC and its integration with oncology could represent a fruitful collaboration among specialists. Case description: We present the case of a 79-year-old woman with advanced breast cancer attending our institute who was referred to our PC Unit because of continuous ear pain, paresthesia around the mouth, strabismus, and facial dysesthesia. The patient was in good clinical condition (Eastern Cooperative Oncology Group 1) and was undergoing chemotherapy at the time. For these reasons, the PC physician carefully assessed the pain characteristics and differential diagnosis and discussed them with the oncologist, radiologist, and neurologist. Joint consultation led to a specific study of Meckel cave by MRI, revealing an extrameningeal gasserian ganglion metastasis, a very rare localization of breast cancer. Conclusion: We present a case that underlines the importance of specialized PC assessment not limited to the control of symptoms. The search for the etiopathogenesis of a patient’s symptoms and the evaluation of overall clinical conditions may be necessary to plan appropriate diagnostic evaluations, target palliative therapies, and achieve effective symptom control.
Real-Time Associations Between Glucose Levels and Fatigue in Type 2 Diabetes: Sex and Time Effects
Authors: Fritschi Cynthia , Park Chang , Quinn Laurie , Collins Eileen G. 
Published: February 2020

Objective: Fatigue is a pervasive and serious complaint among aging adults with type 2 diabetes. Anecdotally, hyperglycemia was thought to cause fatigue, but prior cross-sectional analyses failed to find any relationship between glucose levels and fatigue. However, study methodology may have caused this relationship to be missed. Our aim was to use concurrent and continuous data across 5 days to examine real-time momentary relationships between glucose and fatigue levels by week, day, and time of day. Additionally, we explored how these relationships differed by sex. Method: Participants ( N = 54, 51% male, 54% non-White) wore continuous glucose monitors and wrist actigraphy into which they inputted fatigue ratings 6–8 times daily during waking hours across 5 days. Generalized estimation equation models were used to explore the relationship between glucose and fatigue when averaged by week, day, and time of day. Differences by sex were also explored. Results: HbA1c and baseline and real-time fatigue were higher in women than in men. Baseline HbA1c and self-reported general fatigue were unrelated. Fatigue levels averaged by day and time of day were higher in women than in men ( p < .05). Glucose and fatigue were significantly related at all levels of data (weekly, daily, and time of day) in women but not men. Conclusions: Our findings suggest that, when measured concurrently, glucose excursions may affect fatigue levels in women.
Adherence and acceptance of a home-based telemonitoring application used by multi-morbid patients aged 65 years and older
Authors: Lang Caroline , Voigt Karen , Neumann Robert , Bergmann Antje , Holthoff-Detto Vjera 
Published: February 2020

Introduction Currently, there are only a small number of comprehensive study results on adherence and acceptance of telemonitoring applications (TMAs) regarding multi-morbid older patients. The ATMoSPHAERE study aimed to develop an information and communication platform for an intersectoral networking of, for example, general practitioners, therapists, social services and the multi-morbid older patient. Methods The study presented was designed as a longitudinal bicentric intervention study which focused on multi-morbid patients aged ≥65 years using home-based telemedical measurement and input devices. The development and testing of this TMA aimed to optimise patients’ health care through intersectoral networking of all treating actors. Quantitative methods of data collection and analysis were used. Results Patients who completed the study were significantly younger than drop-outs and non-participants. The mental health of study patients significantly improved between the beginning and end of TMA use. The main reason for non-participation in the study was the high time expenditure when participating in the study. No perceived (information) benefits for health and insufficient content variety were the main reasons for drop-out. Appropriateness and handling of TMAs must be aligned with the needs of the heterogeneous user group of multi-morbid patients in order to increase acceptance and the added value of TMAs. Telemonitoring hardware should be oriented on functional capabilities of the older target group. Telemonitoring software content requires an individual, disease-specific approach for patients. The TMA should be unobtrusively integrated into usual daily life and be used to an appropriate extent according to the underlying disease in order to avoid stressing patients. With regard to adherence concerning TMAs, it is crucial to provide a contact person who is always available for patients having problems handling TMAs. Health concerns and questions can thus be addressed early, providing a feeling of safety in the care process. Discussion User acceptance of TMAs is an essential indicator and driver for use and for future implementation efforts in health care. In order to achieve maximum user centricity in development processes, patients must be involved as experts, co-designers and future users, considering their needs and perceptions.
Breaking New Ground: Gestalt and Person Centred Approaches. A Therapeutic Relationship with People who have Profound Disabilities
Authors: Barber J. 
Published: February 2020

This paper briefly examines some elements of Gestalt therapy within a person-centred approach to counselling. Specific elements of the Gestalt process are examined in the context of facilitating a therapeutic relationship with a person with profound learning and physical disabilities. These elements are ‘sensation’ and ‘awareness’. In the context of ‘helping’ people with profound disabilities, sensation and awareness are elements of the Gestalt process, which can facilitate expression of emotion without speech. Other elements may require some verbalization. A personal interaction with a woman who has profound learning and physical disabilities is briefly described, in order to illustrate how the Gestalt approach can provide a vehicle for the experiencing, communication and liberation of ‘self’, without dependence upon verbal communication.
The Contacts that People with Learning Disabilities Have with Health and Social Services
Authors: McConkey R. , McAteer D. 
Published: February 2020

This study summarizes all the documented service inputs that people with learning disabilities received from one community health and social services trust in Northern Ireland during a 12-month period. Using data obtained from two computer-based recording systems used in Northern Ireland, the extent and type of service provision for this population is described. In all, 10 different health professionals were mainly involved with some inputs from a further six health workers, while social services offered a further eight service inputs. However, the services provided varied across different age groupings and levels of dependency. Three key issues are discussed: the number of different professionals involved; the co-ordination of service inputs and the criteria used to determine which persons receive a service and those who do not. The difficulties involved in undertaking an audit of this type are outlined but the potential contribution to achieving more cost-beneficial services are noted.
Loncastuximab tesirine, an anti-CD19 antibody-drug conjugate, in relapsed/refractory B-cell acute lymphoblastic leukemia
Authors: Jain Nitin , Stock Wendy , Zeidan Amer , Atallah Ehab , McCloskey James , Heffner Leonard , Tomlinson Benjamin , Bhatnagar Bhavana , Feingold Jay , Ungar David , Chao Grace , Zhang Xiaoyan , Qin Yajuan , Havenith Karin , Kantarjian Hagop , Wieduwilt Matthew J. 
Published: February 2020

Abstract
Relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) remains a therapeutic challenge. Loncastuximab tesirine is an antibody-drug conjugate against CD19, an antigen expressed in many B-cell malignancies. This open-label, single-arm, dose-escalation, dose-expansion study assessed the safety, tolerability, pharmacokinetics (PKs), immunogenicity, and preliminary clinical activity of loncastuximab tesirine in adults with R/R B-ALL. A total of 35 patients were enrolled, with a median age of 55 years (range, 20-80) and a median of 3 prior therapies (range, 1-15). All patients received at least 1 IV infusion of loncastuximab tesirine at 15 to 150 μg/kg once every 3 weeks (Q3W; n = 30) or 50 μg/kg IV weekly (n = 5). Common treatment-emergent adverse events (TEAEs) were nausea (42.9%), febrile neutropenia (37.1%), and reversible liver test abnormalities. Grade ≥3 TEAEs were reported in 85.7% patients, most commonly febrile neutropenia and other hematologic abnormalities and reversible liver test abnormalities. There were no treatment-related deaths. Four patients (11.4%) had grade 2 infusion-related reactions, and 1 patient (150 μg/kg Q3W) had a dose-limiting toxicity of hyperbilirubinemia that resolved within 6 days without further action. The maximum tolerated dose was not reached. Three patients achieved complete responses, 1 each at 30, 120, and 150 μg/kg Q3W. PK studies showed marked interpatient variability, with target-mediated drug disposition seeming to contribute to time- and dose-dependent disposition. No clinically relevant anti–drug-antibody formation occurred. The trial was terminated in the dose-escalation phase because of slow accrual. This trial was registered at www.clinicaltrials.gov as NCT02669264.
Nickel allergy is associated with wheezing and asthma in a cohort of young German adults: results from the SOLAR study
Authors: Kolberg Laura , Forster Felix , Gerlich Jessica , Weinmayr Gudrun , Genuneit Jon , Windstetter Doris , Vogelberg Christian , von Mutius Erika , Nowak Dennis , Drexler Hans , Sch�fer Torsten , Radon Katja 
Published: February 2020

Background
Nickel allergy is the most prevalent contact allergy. It belongs to a different hypersensitivity type to asthma and rhinoconjunctivitis. The aim of this analysis was to assess whether self-reported nickel allergy is associated with incident wheezing, asthma and rhinoconjunctivitis in young German adults, taking into account potential effect modification by sex.

Methods
In total, 2051 (70.6%) participants aged 19�24 years took part in the second phase of SOLAR (Study on Occupational Allergy Risks), a follow-up study of ISAAC II (the second phase of the International Study of Asthma and Allergies in Childhood) in Germany. Self-reported nickel allergy, as well as having pierced ears, and the three outcomes incident wheezing, asthma and rhinoconjunctivitis, were analysed stratified for sex. Logistic regression adjusted for potential confounders was performed.

Results
An association between self-reported nickel allergy and incident wheezing was observed for men and women, while only in males did pierced ears show a significant association with the outcome (adjusted OR 2.26, 95% CI 1.10�4.62). Also only in males, self-reported nickel allergy was associated with elevated odds for incident asthma (adjusted OR 4.34, 95% CI 1.22�15.41). Neither in men nor in women was a significant association observed for incident rhinoconjunctivitis.

Conclusion
Our results suggest that self-reported nickel allergy is associated with incident wheezing. Whether this association is due to environmental or genetic predisposition, or due to an overlap of the mechanisms of type I and type IV hypersensitivity, needs to be elucidated.
Flexible Bio-tensegrity Manipulator with Multi-degree of Freedom and Variable Structure
Authors: Wei Dunwen , Gao Tao , Mo Xiaojuan , Xi Ruru , Zhou Cong 
Published: February 2020

AbstractConventional manipulators with rigid structures and stiffness actuators have poor flexibility, limited obstacle avoidance capability, and constrained workspace. Some developed flexible or soft manipulators in recent years have the characteristics of infinite degrees of freedom, high flexibility, environmental adaptability, and extended manipulation capability. However, these existing manipulators still cannot achieve the shrinking motion and independent control of specified segments like the animals, which hinders their applications. In this paper, a flexible bio-tensegrity manipulator, inspired by the longitudinal and transversal muscles of octopus tentacles, was proposed to mimic the shrinking behavior and achieve the variable motion patterns of each segment. Such proposed manipulator uses the elastic spring as the backbone, which is driven by four cables and has one variable structure mechanism in each segment to achieve the independent control of each segment. The variable structure mechanism innovatively contains seven lock-release states to independently control the bending and shrinking motion of each segment. After the kinematic modeling and analysis, one prototype of such bionic flexible manipulator was built and the open-loop control method was proposed. Some proof-of-concept experiments, including the shrinking motion, bending motion, and variable structure motion, were carried out by controlling the length of four cables and changing the lock-release states of the variable structure mechanism, which validate the feasibility and validity of our proposed prototype. Meanwhile, the experimental results show the flexible manipulator can accomplish the bending and shrinking motion with the relative error less than 6.8% through the simple independent control of each segment using the variable structure mechanism. This proposed manipulator has the features of controllable degree-of-freedom in each segment, which extend their environmental adaptability, and manipulation capability.
Steam treatment to enhance rice straw binderless board focusing hemicellulose and cellulose decomposition products
Authors: Kurokochi Yoko , Sato Masatoshi 
Published: February 2020

AbstractRice straw is a troublesome biomass for an industrial application because of its high silica content and the wax-like substances covering the surface. At manufacturing binderless boards, which are considered environmentally friendly as they do not contain synthetic resins, rice straw silica contributed to water resistance, while the wax-like substances adversely affected self-bonding. This study investigated the effects of steam treatment on the self-bonding of binderless boards manufactured from rice straw. The chemical changes during steam treatment were examined by gas chromatography–mass spectrometry (GC–MS), and their influence on the bonding properties is discussed. Internal bonding strength and water resistance significantly increased by steam treatment. They also increased with increasing pressing temperature, and decreasing particle size. GC/MS analysis showed that not only hemicellulose and lignin, but also amorphous cellulose was decomposed during the steam treatment. Among the degradation products, 5-hydroxymethylfurfural was suggested to contribute to self-bonding during hot-pressing, while furfural was vaporized from the rice straw. Fine-grinding to below 150 μm after steam treatment resulted in high water resistance and an internal bonding strength of 0.6 MPa, which met the Japan Industrial Standards (JIS) requirement for Type-30 medium-density fiberboard (MDF). This mild pretreatment offers an alternative to steam explosion.
LINC00511 promotes proliferation and invasion by sponging miR-515-5p in gastric cancer
Authors: Wang Di , Liu Ketong , Chen Erdong 
Published: February 2020

Abstract
Background
Long non-coding RNAs (lncRNAs) are known to be involved in tumorigenesis. The functions of LINC00511 in gastric cancer are poorly understood.

Methods
Quantitative RT-PCR was performed to investigate the levels of LINC00511 in gastric cancer tissues and cell lines. CCK-8, flow cytometry, wound-healing and Transwell assays were performed to examine cellular functions. The underlying regulatory mechanisms of LINC00511 in gastric cancer progression were determined using luciferase reporter and RIP assays.

Results
LINC00511 levels were significantly higher in gastric cancer tissues and cell lines than in normal samples. The high expression of LINC00511 in gastric cancer patient samples positively correlated with advanced clinical characters and poor prognosis. Depleting LINC00511 reduced tumor cell proliferation, migration and invasion, slowed tumor growth, and accelerated cell apoptosis. Our mechanistic study results indicated that LINC00511 promotes gastric cancer progression in a miR-515-5p-dependent manner.

Conclusion
We established that LINC00511 may contribute to the proliferation and invasion of gastric cancer cells by modulating miR-515-5p, indicating that LINC00511 may be a potential molecular target for the development of anti-cancer drugs.