bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follow-up and Clinical Outcomes of Human Immunodeficiency Virus (HIV)–Exposed Infants in A Low-Prevalence Setting in A Multidisciplinary Model of Care in Australia: The Children’s HIV Exposure Study 1
Authors: Shepherd Kathryn , Giles Michelle , Blyth Karen , O’Keeffe Fiona , Bordun Louise , Connell Tom G , Bryant Penelope A 
Published: January 2020

AbstractBackgroundPrevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) is effective, but outcome information beyond the postnatal period in low-prevalence settings is scarce. A multidisciplinary model of care (MOC) was developed to ensure PMTCT. Our aims in this study were to assess how well HIV-exposed infants are followed up through this MOC and to determine infant outcomes to age 18 months.MethodsThis was a multicenter, prospective study of infants exposed to HIV during pregnancy, born 1 September 2009–31 August 2016 in Victoria, Australia.ResultsThere were 129 live births from 127 pregnancies. There were no episodes of HIV transmission. Sixteen (13%) infants were born prematurely, 15 (12%) had low birthweight, and 6 (5%) had a congenital anomaly. There were 122 (95%) infants with an HIV polymerase chain reaction (PCR) within 2 weeks of birth. The proportion in the MOC reduced from 95% at 2 weeks postnatally to 75% by 18 months. Eighty-eight percent cared for within the MOC had 2 viral PCR tests completed after stopping antiretroviral prophylaxis compared with 22% of those outside of the MOC. By 18 months, 84/126 (67%) children attended follow-up, with higher rates within the MOC than outside (76% vs 6%; odds ratio, 46; 95% confidence interval, 6 to 365; P &lt; .001).ConclusionsHIV-exposed, uninfected infants in this low-prevalence setting had good prospective follow-up through this MOC to 3 months. The decrease in follow-up by 18 months could be addressed in several ways, including expanding the MOC and providing better links to regional/rural services.
AI-enabled business models in legal services: from traditional law firms to next-generation law companies?
Authors: Armour John , Sako Mari 
Published: January 2020

AbstractWhat will happen to law firms and the legal profession when the use of artificial intelligence (AI) becomes prevalent in legal services? We address this question by considering three related levels of analysis: tasks, business models, and organizations. First, we review AI’s technical capabilities in relation to tasks, to identify contexts where it is likely to replace or augment humans. AI is capable of doing some, but not all, legal tasks better than lawyers and is augmented by multidisciplinary human inputs. Second, we identify new business models for creating value in legal services by applying AI. These differ from law firms’ traditional legal advisory business model, because they require technological (non-human) assets and multidisciplinary human inputs. Third, we analyze the organizational structure that complements the old and new business models: the professional partnership (P2) is well-adapted to delivering the legal advisory business model, but the centralized management, access to outside capital, and employee incentives offered by the corporate form appear better to complement the new AI-enabled business models. Some law firms are experimenting with pursuing new and old business models in parallel. However, differences in complements create conflicts when business models are combined. These conflicts are partially externalized via contracting and segregated and realigned via vertical integration. Our analysis suggests that law firm experimentation with aligning different business models to distinct organizational entities, along with ethical concerns, will affect the extent to which the legal profession will become ‘hybrid professionals’.
xGASS: Robust quantification of asymmetries in global H i spectra and their relationship to environmental processes
Authors: Watts Adam B , Catinella Barbara , Cortese Luca , Power Chris 
Published: January 2020

ABSTRACT
We present an analysis of asymmetries in global H i spectra from the extended GALEX Arecibo SDSS Survey (xGASS), a stellar mass-selected and gas fraction-limited survey which is representative of the H i properties of galaxies in the local Universe. We demonstrate that the asymmetry in a H i spectrum is strongly linked to its signal-to-noise meaning that, contrary to what was done in previous works, asymmetry distributions for different samples cannot be compared at face value. We develop a method to account for noise-induced asymmetry and find that the typical galaxy detected by xGASS exhibits higher asymmetry than what can be attributed to noise alone, with 37 per cent of the sample showing asymmetry greater than 10 per cent at an 80 per cent confidence level. We find that asymmetric galaxies contain, on average, 29 per cent less H i mass compared to their symmetric counterparts matched in both stellar mass and signal-to-noise. We also present clear evidence that satellite galaxies, as a population, exhibit more asymmetric H i spectra than centrals and that group central galaxies show a slightly higher rate of H i asymmetries compared to isolated centrals. All these results support a scenario in which environmental processes, in particular those responsible for gas removal, are the dominant driver of asymmetry in xGASS.
Bubble mapping with the Square Kilometre Array – I. Detecting galaxies with Euclid, JWST, WFIRST, and ELT within ionized bubbles in the intergalactic medium at z &gt; 6
Authors: Zackrisson Erik , Majumdar Suman , Mondal Rajesh , Binggeli Christian , Sahlén Martin , Choudhury Tirthankar Roy , Ciardi Benedetta , Datta Abhirup , Datta Kanan K , Dayal Pratika , Ferrara Andrea , Giri Sambit K , Maio Umberto , Malhotra Sangeeta , Mellema Garrelt , Mesinger Andrei , Rhoads James , Rydberg Claes-Erik , Shimizu Ikkoh 
Published: January 2020

ABSTRACT
The Square Kilometre Array (SKA) is expected to provide the first tomographic observations of the neutral intergalactic medium at redshifts z &gt; 6 and pinpoint the locations of individual ionized bubbles during early stages of cosmic reionization. In scenarios where star-forming galaxies provide most of the ionizing photons required for cosmic reionization, one expects the first ionized bubbles to be centred on overdensities of such galaxies. Here, we model the properties of galaxy populations within isolated, ionized bubbles that SKA-1 should be able to resolve at z ≈ 7–10, and explore the prospects for galaxy counts within such structures with various upcoming near-infrared telescopes. We find that, for the bubbles that are within reach of SKA-1 tomography, the bubble volume is closely tied to the number of ionizing photons that have escaped from the galaxies within. In the case of galaxy-dominated reionization, galaxies are expected to turn up above the spectroscopic detection threshold of JWST and ELT in even the smallest resolvable bubbles at z ≤ 10. The prospects of detecting galaxies within these structures in purely photometric surveys with Euclid, WFIRST, JWST, or ELT are also discussed. While spectroscopy is preferable towards the end of reionization to provide a robust sample of bubble members, multiband imaging may be a competitive option for bubbles at z ≈ 10, due to the very small number of line-of-sight interlopers expected at these redshifts.
Perturbation dynamics in Keplerian flow under external stochastic forcing
Authors: Razdoburdin D N 
Published: January 2020

ABSTRACT
We investigate the dynamics of linear perturbations in Keplerian flow under external stochastic force. To abstract from the details of flow structure and boundary conditions, we consider the problem in the shearing box approximation. An external force is assumed to have zero mean, even so, induced perturbations form a steady state, which provides angular momentum transfer to the periphery of the flow. The most effective scenario is based on the transient amplification of induced vortices with the following emission of a shearing sound wave, wherein the maximum of the flux linearly depends on Reynolds number. Thus such a mechanism is significant for astrophysical flows, for which enormous Reynolds numbers are typical. At the same time, addressing the problem analytically, we find that for incompressible fluid in the shearing box approximation stochastic forcing does not lead to average angular momentum transfer. Thus the compressibility of the fluid plays an important role here, and one cannot neglect it.
Spectral and temporal properties of Compton scattering by mildly relativistic thermal electrons
Authors: Zdziarski Andrzej A , Szanecki Michał , Poutanen Juri , Gierliński Marek , Biernacki Paweł 
Published: January 2020

ABSTRACT
We have obtained new solutions and methods for the process of thermal Comptonization. We modify the solution to the kinetic equation of Sunyaev and Titarchuk to allow its application up to mildly relativistic electron temperatures and optical depths $\gtrsim {1}$. The solution can be used for spectral fitting of X-ray spectra from astrophysical sources. We also have developed an accurate Monte Carlo method for calculating spectra and timing properties of thermal Comptonization sources. The accuracy of our kinetic equation solution is verified by comparison with the Monte Carlo results. We also compare our results with those of other publicly available methods. Furthermore, based on our Monte Carlo code, we present distributions of the photon emission times and the evolution of the average photon energy for both up and down scattering.
Comparative gonadotoxicity of the chemotherapy drugs cisplatin and carboplatin on prepubertal mouse gonads
Authors: Allen Caroline M , Lopes Federica , Mitchell Rod T , Spears Norah 
Published: January 2020

AbstractThe treatment of childhood cancer with chemotherapy drugs can result in infertility in adulthood. Newer generations of drugs are developed to replace parent drugs, with the potential benefits of less toxic side effects. For platinum alkylating-like drugs, in contrast to the parent compound cisplatin, the newer-generation drug carboplatin is reported to have reduced toxicity in some respects, despite being administered at 5–15 times higher than the cisplatin dose. Whether carboplatin is also less toxic than cisplatin to the reproductive system is unknown. Here we compare the gonadotoxic impact of cisplatin and carboplatin on female and male mouse prepubertal gonads. In vitro cultured CD1 mouse ovaries or testis fragments were exposed to either cisplatin or carboplatin for 24 h on Day 2 of culture and analysed by Day 6. A dose response for each drug was determined for the ovary (0.5, 1 & 5 μg/ml cisplatin and 1, 5 & 10 μg/ml carboplatin) and the testis (0.01, 0.05 & 0.1 μg/ml cisplatin and 0.1, 0.5 & 1 μg/ml carboplatin). For the ovary, unhealthy follicles were evident from 1 μg/ml cisplatin (73% unhealthy, P = 0.001) and 5 μg/ml carboplatin (84% unhealthy, P = 0.001), with a concomitant reduction in follicle number (P = 0.001). For the testis, the proliferating germ cell population was significantly reduced from 0.05 μg/ml cisplatin (73% reduction, P = 0.001) and 0.5 μg/ml carboplatin (75% reduction, P = 0.001), with no significant impact on the Sertoli cell population. Overall, results from this in vitro animal model study indicate that, at patient equivalent concentrations, carboplatin is no less gonadotoxic than cisplatin.
Ethical Considerations in Music Therapy Private Practice: A Review of the Literature
Authors: Wilhelm Kyle 
Published: January 2020

Abstract
For music therapists in private practice, ethical choices are embedded within every professional action and interaction. While many of these ethical choices are common to all clinicians, some are specific to private practice. Literature from music therapy and other healthcare professions, as well as business literature, were reviewed to identify ethical dilemmas commonly found in private practice, discuss potential reasons for unethical behavior, and explore how music therapists in private practice can work through ethical dilemmas.
A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells
Authors: Li Xie , Zhang Changcheng , Xu Xiaopei , Miao Jun , Yao Jing , Liu Renmei , Zhao Yuzheng , Chen Xianjun , Yang Yi 
Published: January 2020

Abstract
Light-regulated modules offer unprecedented new ways to control cellular behaviour with precise spatial and temporal resolution. Among a variety of bacterial light-switchable gene expression systems, single-component systems consisting of single transcription factors would be more useful due to the advantages of speed, simplicity, and versatility. In the present study, we developed a single-component light-activated bacterial gene expression system (eLightOn) based on a novel LOV domain from Rhodobacter sphaeroides (RsLOV). The eLightOn system showed significant improvements over the existing single-component bacterial light-activated expression systems, with benefits including a high ON/OFF ratio of &gt;500-fold, a high activation level, fast activation kinetics, and/or good adaptability. Additionally, the induction characteristics, including regulatory windows, activation kinetics and light sensitivities, were highly tunable by altering the expression level of LexRO. We demonstrated the usefulness of the eLightOn system in regulating cell division and swimming by controlling the expression of the FtsZ and CheZ genes, respectively, as well as constructing synthetic Boolean logic gates using light and arabinose as the two inputs. Taken together, our data indicate that the eLightOn system is a robust and highly tunable tool for quantitative and spatiotemporal control of bacterial gene expression.
Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI
Authors: Laws Maxwell T , Bonomi Robin E , Gelovani David J , Llaniguez Jeremy , Lu Xin , Mangner Thomas , Gelovani Juri G 
Published: January 2020

Abstract

Background
Several studies demonstrated that glioblastoma multiforme progression and recurrence is linked to epigenetic regulatory mechanisms. Sirtuin 1 (SIRT1) plays an important role in glioma progression, invasion, and treatment response and is a potential therapeutic target. The aim of this study is to test the feasibility of 2-[18F]BzAHA for quantitative imaging of SIRT1 expression–activity and monitoring pharmacologic inhibition in a rat model of intracerebral glioma.

Methods
Sprague Dawley rats bearing 9L (N = 12) intracerebral gliomas were injected with 2-[18F]BzAHA (300–500 µCi/animal i.v.) and dynamic positron-emission tomography (PET) imaging was performed for 60 min. Then, SIRT1 expression in 9L tumors (N = 6) was studied by immunofluorescence microscopy (IF). Two days later, rats with 9L gliomas were treated either with SIRT1 specific inhibitor EX-527 (5 mg/kg, i.p.; N = 3) or with histone deacetylases class IIa specific inhibitor MC1568 (30 mg/kg, i.p.; N = 3) and 30 min later were injected i.v. with 2-[18F]BzAHA. PET-computerized tomography-magnetic resonance (PET/CT/MR) images acquired after EX-527 and MC1568 treatments were co-registered with baseline images.

Results
Standard uptake values (SUVs) of 2-[18F]BzAHA in 9L tumors measured at 20 min post-radiotracer administration were 1.11 ± 0.058 and had a tumor-to-brainstem SUV ratio of 2.73 ± 0.141. IF of 9L gliomas revealed heterogeneous upregulation of SIRT1, especially in hypoxic and peri-necrotic regions. Significant reduction in 2-[18F]BzAHA SUV and distribution volume in 9L tumors was observed after administration of EX-527, but not MC1568.

Conclusions
PET/CT/MRI with 2-[18F]BzAHA can facilitate studies to elucidate the roles of SIRT1 in gliomagenesis and progression, as well as to optimize therapeutic doses of novel SIRT1 inhibitors.
Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
Authors: Ishimaru Kai , Sasaki Mari , Narimatsu Hiroshi , Arimizu Yoko , Gotoh Yasuhiro , Nakamura Keiji , Hayashi Tetsuya , Ogura Yoshitoshi 
Published: January 2020

Abstract
No outbreaks caused by Escherichia coli–producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.
Technologies of Crime Prediction: The Reception of Algorithms in Policing and Criminal Courts
Authors: Brayne Sarah , Christin Angèle 
Published: January 2020

Abstract
The number of predictive technologies used in the U.S. criminal justice system is on the rise. Yet there is little research to date on the reception of algorithms in criminal justice institutions. We draw on ethnographic fieldwork conducted within a large urban police department and a midsized criminal court to assess the impact of predictive technologies at different stages of the criminal justice process. We first show that similar arguments are mobilized to justify the adoption of predictive algorithms in law enforcement and criminal courts. In both cases, algorithms are described as more objective and efficient than humans’ discretionary judgment. We then study how predictive algorithms are used, documenting similar processes of professional resistance among law enforcement and legal professionals. In both cases, resentment toward predictive algorithms is fueled by fears of deskilling and heightened managerial surveillance. Two practical strategies of resistance emerge: foot-dragging and data obfuscation. We conclude by discussing how predictive technologies do not replace, but rather displace discretion to less visible—and therefore less accountable—areas within organizations, a shift which has important implications for inequality and the administration of justice in the age of big data.
The Impact of Cross-Species Gene Flow on Species Tree Estimation
Authors: Jiao Xiyun , Flouri Tomáš , Rannala Bruce , Yang Ziheng 
Published: January 2020

AbstractRecent analyses of genomic sequence data suggest cross-species gene flow is common in both plants and animals, posing challenges to species tree estimation. We examine the levels of gene flow needed to mislead species tree estimation with three species and either episodic introgressive hybridization or continuous migration between an outgroup and one ingroup species. Several species tree estimation methods are examined, including the majority-vote method based on the most common gene tree topology (with either the true or reconstructed gene trees used), the UPGMA method based on the average sequence distances (or average coalescent times) between species, and the full-likelihood method based on multilocus sequence data. Our results suggest that the majority-vote method based on gene tree topologies is more robust to gene flow than the UPGMA method based on coalescent times and both are more robust than likelihood assuming a multispecies coalescent (MSC) model with no cross-species gene flow. Comparison of the continuous migration model with the episodic introgression model suggests that a small amount of gene flow per generation can cause drastic changes to the genetic history of the species and mislead species tree methods, especially if the species diverged through radiative speciation events. Estimates of parameters under the MSC with gene flow suggest that African mosquito species in the Anopheles gambiae species complex constitute such an example of extreme impact of gene flow on species phylogeny. [IM; introgression; migration; MSci; multispecies coalescent; species tree.]
Hearing thresholds of small native Australian mammals – red-tailed phascogale (Phascogale calura), kultarr (Antechinomys laniger) and spinifex hopping-mouse (Notomys alexis)
Authors: Old Julie M , Parsons Carl , Tulk Melissa L 
Published: January 2020

Abstract
Hearing is essential for communication, to locate prey and to avoid predators. We addressed the paucity of information regarding hearing in Australian native mammals by specifically assessing the hearing range and sensitivity of the red-tailed phascogale (Phascogale calura), the kultarr (Antechinomys laniger) and the spinifex hopping-mouse (Notomys alexis). Auditory brainstem response (ABR) audiograms were used to estimate hearing thresholds within the range of 1–84 kHz, over a dynamic range of 0–80 dB sound pressure level (SPL). Phascogales had a hearing range of 1–40 kHz, kultarrs 1–35 kHz and hopping-mice 1–35 kHz, with a dynamic range of 17–59 dB SPL, 20–80 dB SPL and 30–73 dB SPL, respectively. Hearing for all species was most sensitive at 8 kHz. Age showed no influence on optimal hearing, but younger animals had more diverse optimal hearing frequencies. There was a relationship between males and their optimal hearing frequency, and greater interaural distances of individual males may be related to optimal hearing frequency. Because nocturnal animals use high-range hearing for prey or predator detection, our study suggests this may also be the case for the species examined in this study. Future studies should investigate their vocalizations and behaviour in their natural environments, and by exposing them to different auditory stimuli.
Recent mitochondrial lineage extinction in the critically endangered Javan rhinoceros
Authors: Margaryan Ashot , Sinding Mikkel-Holger S , Liu Shanlin , Vieira Filipe Garrett , Chan Yvonne L , Nathan Senthilvel K S S , Moodley Yoshan , Bruford Michael W , Gilbert M Thomas P 
Published: January 2020

Abstract
The Javan rhinoceros (Rhinoceros sondaicus) is one of five extant rhinoceros species and among the rarest large mammals on Earth. Once widespread across Southeast Asia, it is now on the verge of extinction, with only one wild population remaining (estimated at ~60 individuals) on the island of Java, Indonesia. To assess the past genetic diversity of the female lineage of R. sondaicus, we generated mitochondrial genome data from eight museum specimens dating back to the 19th century, before the range of the Javan rhinoceros was dramatically reduced, for comparison against mitochondrial DNA (mtDNA) sequences of current R. sondaicus and other rhinoceros species. We succeeded in reconstructing five full and three partial ancient mitogenomes from the eight samples. We used BEAST to assess the phylogenetic relationship of the five extant rhinoceros species and the historical samples. The results show that the oldest and most diverse mtDNA lineages of R. sondaicus are found in historical samples, indicating a significant reduction of mtDNA diversity in modern Javan rhinos. We anticipate that the newly sequenced data will represent a useful resource for improving our understanding of evolutionary history of this species, should future studies be able to increase the available dataset. We hope this information may help in conservation efforts for this species.