bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectivity of dexamethasone in patients undergoing off-pump coronary artery bypass surgery
Authors: Hanafy Dudy Arman , Harta I Komang Adhi Parama , Prasetya I Made Indra , Busroh Pribadi Wiranda , Soetisna Tri Wisesa , Sugisman  , Wartono Dicky Aligheri , Tjubandi Amin , Herlambang Bagus 
Published: December 2020

Background Based on our previous pilot study, systemic inflammatory response syndrome is more common in off-pump compared to on-pump coronary artery bypass. Therefore, we conducted a clinical trial of dexamethasone in patients undergoing off-pump coronary artery bypass. Methods Sixty consecutive patients undergoing off-pump coronary artery bypass were enrolled from August 2018 to January 2019 and randomized to a dexamethasone or placebo group of 30 each. Clinical outcomes were analyzed. Results There was a lower incidence of major adverse cardiac events in the dexamethasone group compared to the placebo group (17% versus 43%, p = 0.024). Clinical outcomes in the dexamethasone group were better than those in the placebo group, in terms of duration of mechanical ventilation ( p = 0.029), intensive care unit stay ( p = 0.028), hospital stay ( p = 0.04), and vasoactive-inotropic score ( p = 0.045). There were significant differences in inflammatory markers between the two groups: interleukin-6 ( p = 0.0001), procalcitonin ( p = 0.0001), and C-reactive protein ( p = 0.0001) were lower in the dexamethasone group. There was a significant association between the incidence of major adverse cardiac events and both interleukin-6 ( p = 0.005) and procalcitonin ( p = 0.007). Conclusion Preoperative dexamethasone in patients undergoing off-pump coronary artery bypass is effective in improving clinical outcomes and controlling the postoperative inflammatory reaction.
BPI and KIR6.1 as significant hub genes for vein graft restenosis
Authors: Bai Yun-peng , Yao Bo-chen , Wang Mei , Liu Xian-kun , Zhu Xiao-long , Wang Lian-qun , Jiang Nan , Guo Zhi-gang , Chen Qing-liang 
Published: December 2020

Background Vein graft restenosis (VGR), which appears to be caused by dyslipidemia following vascular transplantation, seriously affects the prognosis and long-term quality of life of patients. Methods This study analyzed the genetic data of restenosis (VGR group) and non-stenosis (control group) vessels from patients with coronary heart disease post-vascular transplantation and identified hub genes that might be responsible for its occurrence. GSE110398 was downloaded from the Gene Expression Omnibus database. A repeatability test for the GSE110398 dataset was performed using R language. This included the identification of differentially expressed genes (DEGs), enrichment analysis via Metascape software, pathway enrichment analysis, and construction of a protein–protein interaction network and a hub gene network. Results Twenty-four DEGs were identified between VGR and control groups. The four most important hub genes ( KIR6.1, PCLP1, EDNRB, and BPI) were identified, and Pearson’s correlation coefficient showed that KIR6.1 and BPI were significantly correlated with VGR. KIR6.1 could also sensitively predict VGR (0.9 < area under the curve ≤1). Conclusion BPI and KIR6.1 were differentially expressed in vessels with and without stenosis after vascular transplantation, suggesting that these genes or their encoded proteins may be involved in the occurrence of VGR.
Book review: S. A. Chatterji, Filming Reality: The Independent Documentary Movement in India, K. P. Jayasankar & A. Monteiro, A Fly in the Curry: Independent Documentary Film in India and A. Sharma, Documentary Films in India: Critical Aesthetics at Work
Authors: Kaushik Ritika 
Published: December 2020

S. A. Chatterji, Filming Reality: The Independent Documentary Movement in India. SAGE Publications, 2015, 320 pp., $59.99. K. P. Jayasankar & A. Monteiro, A Fly in the Curry: Independent Documentary Film in India. SAGE Publications, 2016, 276 pp., $54.99. A. Sharma, Documentary Films in India: Critical Aesthetics at Work. Palgrave Macmillan, 2015, XIII, 276 pp., 41.59€.
Acceptability of the “Love, Sex, & Choices” HIV Prevention Intervention by Hispanic Female College Students
Authors: Jones Sandra Gracia , Jones Rachel , Fenkl Eric A. , Lacroix-Williams Lorraine , Simon Sharon , Chadwell Katherine 
Published: December 2020

Introduction: Hispanic women are affected by HIV. “Love, Sex & Choices” (LSC) is an innovative 12-episode urban soap opera video series targeting young adult Black women streamed to smartphones. This study purpose was to determine whether LSC is an acceptable HIV prevention intervention for female Hispanic college students in South Florida. Method: After institutional review board approval, female Hispanic college students were recruited from two campuses to watch the LSC video series and complete an online evaluation survey. Results: Study participants ( n =101) evaluated LSC as definitely/probably important for women (97.0%), helpful for making relationship decisions (86.2%), changing attitudes about having sex (79.2%), asking partners to use a condom (80.2%), leaving partners who won’t use condoms (74.2%), handling oneself in tough situations in a relationship (79.2%), and getting an HIV test (83.2%). Participants liked/related to LSC and thought their friends would also like the series. Conclusions: Results indicated that young Hispanic women related to the video series, were likely to get HIV tested after watching the video series, found the story lines realistic, and thought their friends would like the series. The next step is to test the effectiveness of LSC to change behaviors of young Hispanic women at risk of HIV.
Phase II randomized trial of a non-steroidal mouth wash for prevention and treatment of stomatitis in women with hormone receptor positive breast cancer treated with everolimus
Authors: Peddi Parvin F. , Tetef Merry , Coluzzi Paul , Arzoo Karo K. , Hu Eddie H. , Berkowitz Maurice J. , Chan David , Moore Dennis , Adams Brad , Wang Xiaoyan , Hurvitz Sara A. 
Published: December 2020

Background: Stomatitis is a frequent dose limiting toxicity of everolimus, an approved therapy for patients with metastatic breast cancer. No randomized trials of a prophylactic measure to prevent mucositis have been reported. Methods: We conducted a phase II, open-label trial in which patients with metastatic breast cancer starting everolimus were randomized to best supportive care (BSC) versus prophylactic use of an oral mucoadhesive, non-steroid containing mouth wash. The primary endpoint was rate of any grade stomatitis as reported by the treating physicians. Secondary endpoints were severity of stomatitis according to the Oral Mucositis Assessment Scale (OMAS) and rates of everolimus dose reduction or discontinuation due to mucositis. Results: Of 61 evaluable patients, 32 were randomized to and treated with oral mucoadhesive and 29 with BSC. Any grade stomatitis developed in 46.9% (15/32) of study arm and 65.5% (19/29) of BSC arm patients ( p = 0.14). The difference between the two arms was significantly in favor of the mucoadhesive arm when mucositis was scored according to the OMAS with average score of 0.3 in study arm versus 0.5 in the control arm ( p = 0.03). There were fewer dose adjustments or therapy discontinuations in the study arm compared with BSC (16% versus 31%, respectively) but the difference did not reach statistical significance. Conclusion: Here we provide early evidence from the first randomized trial supporting the use of oral prophylactic mucoadhesive for everolimus-associated stomatitis. A trial comparing prophylactic oral mucoadhesive to steroid mouth wash may be warranted.
Endoscopic radiofrequency facet joint treatment in patients with low back pain: technique and long-term results. A prospective cohort study
Authors: Meloncelli Stefano , Germani Giorgio , Urti Ignazio , Divizia Marco , Rosciano Maria , Puntillo Filomena , Paladini Antonella , Varrassi Giustino 
Published: December 2020

Aims: The aim of the study was to evaluate the efficacy of endoscopic rhizotomy (ER) for denervation of lumbar facet joints in patients with chronic low back pain (LBP) due to facet joint syndrome (FJS). Methods: A total of 50 consecutive patients suffering from chronic LBP due to facet joints were screened to be treated with ER. The patients participating in the study had a 2-year follow up. Numeric Rating Scale (NRS) and Oswestry Disability Index (ODI) were assessed in the preoperative and postoperative period. To evaluate secondary endpoints, patients were divided into groups. One group included the patients previously treated with percutaneous radiofrequency (RF). The other group comprised patients at their first interventional treatment. We also compared patients dividing them by age and by number of joints treated, trying to elucidate if these parameters could be predictive of effectiveness of the procedure. Results: All patients had a reduction in NRS and an improvement in ODI. NRS was reduced significantly after 1 month and remained the same until the end of the study. ODI was significantly improved from T1 (1 month after surgery) up to T7 (end of the study). The improvements did not differ whether already treated with percutaneous rhizotomy or not. Patients less than 60 years or with 1–2 joints treated had better improvement compared with the others. Conclusion: The results obtained demonstrate that ER for denervation of the facet joint is an effective treatment in patients with chronic LBP, with consistent and stable results at 2-year follow up. The technique has a rapid learning curve and no major complications occurred. Moreover, the previous percutaneous RF treatment had no influence on the results obtained with endoscopic technique. There is evidence that best results are obtained in younger patients and/or in patients with 1–2 joints treated. Lay summary Low-back pain has facet joints inflammation or degeneration as pain generator in 20–40% of cases. Nervous lesion of the dorsal ramus innervating the facet joints has been shown as an efficacious treatment to obtain good analgesia. Percutaneous techniques have provided short term results for several reasons. This research aimed to see whether endoscopic denervation, which guarantees a more precise approach to anatomical structure, would result in more durable results. The study conducted on 40 patients has made it clear that this approach gives significant analgesia for at least 2 years, which was the time of patient follow up.
Book review: Avik Chanda, Dara Shukoh: The Man Who Would be King and Supriya Gandhi, The Emperor Who Never Was: Dara Shukoh in Mughal India
Authors: Moosvi Shireen 
Published: December 2020

Avik Chanda, Dara Shukoh: The Man Who Would be King (Noida: Harper Collins), 2019, 337 pp., ₹699 (Hb). Supriya Gandhi, The Emperor Who Never Was: Dara Shukoh in Mughal India (Cambridge), 2020, 338 pp., $29.95 (Hb).
Book review: John Guy, Art and Independence: Y.G. Srimati and the Indian Style and Geeti Sen, Meera Mukherjee: Purity of Vision
Authors: Das Shilpi 
Published: December 2020

John Guy, Art and Independence: Y.G. Srimati and the Indian Style (Ahmedabad: Mapin Publishing Pvt. Ltd), 2019, 144 pp., 66 colour illustrations, 63 colour photographs, ₹1,750 (Hb). Geeti Sen, Meera Mukherjee: Purity of Vision (Ahmedabad: Mapin Publishing Pvt. Ltd), 2018, 152 pp., 146 colour illustrations, 26 colour photographs, ₹2,950 (Hb).
Animal-assisted therapy on happiness and life quality of chronic psychiatric patients living in psychiatric residential care homes: a randomized controlled study
Authors: Sahebalzamani Mohammad , Rezaei Omid , Moghadam Ladan Fattah 
Published: December 2020

Abstract
Background
Psychiatric patients who live in psychiatric residential care homes may often feel a loss of autonomy, decision making, and participation in social activities. They usually have few or no visitors and also do not have any purpose for living. Animals may increase the happiness and quality of life of psychiatric patients. This study aimed to evaluate the effects of Animal-Assisted Therapy (AAT) on happiness and quality of life of chronic psychiatric patients living in psychiatric residential care homes in Tehran, Iran.

Methods
This randomized controlled trial was conducted with 70 males with a chronic psychiatric disorder who were living in psychiatric residential care homes in Tehran, Iran, in 2016. The patients were randomly selected and divided into animal therapy intervention group and control group. Patients in the intervention group received animal-therapy with a bird for eight weeks. Patients in the control group received no intervention. The Oxford Happiness Inventory evaluated all patients pre and post-intervention. To evaluate life quality, the Wisconsin Quality of Life Index was used. Data were statically analyzed using SPSS Ver.19.0. ANCOVA with pretest statistical control. The significance level was set as p < 0.05.

Results
The mean age in both control and intervention groups were 47.12 and 45.82 years, and the mean age of illness onset for both control and intervention groups was 18.94 and 16.83 years, respectively. The result of this study showed that happiness in the intervention group had significantly increased (p < 0.001). The results also showed that the quality of life in four sub-domains increased significantly.

Conclusion
To bring happiness to chronic psychiatric patients living in psychiatric residential care homes is essential and may result in returning them to society and healthy life. The results of this study showed that AAT was helpful for chronic psychiatric patients living in psychiatric residential care homes and not only made them happy but also increased their quality of life.

Trial registration
This was registered in Iranian Registry of Clinical Trials (IRCT) (clinical trial code: IRCT20101013004922N4. Registered 2018-08-19. Retrospectively registered, https://www.irct.ir/trial/32390
Psychosocial support interventions for improved adherence and retention in ART care for young people living with HIV (10–24 years): a scoping review
Authors: Okonji Emeka F. , Mukumbang Ferdinand C. , Orth Zaida , Vickerman-Delport Shelley A. , Van Wyk Brian 
Published: December 2020

Abstract
Background
Mental health disorders such as high levels of anxiety, isolation, depression and suicide ideation reported among young people living with HIV (10–24 years;YPLHIV) contribute significantly to poor medication adherence and retention in care. While there is evidence supporting the role of psychosocial support interventions in promoting adherence and retention in antiretroviral treatment (ART) among adults living with HIV, there is little evidence on the role of psychosocial support on medication adherence among YPLHIV. This scoping review was designed to identify and classify the types and effects of psychosocial support interventions designed to improve adherence and retention in ART among YPLHIV globally.

Method
We searched six electronic databases (i.e., Scopus, Pubmed and EBSCOHost (Academic Search Premier, CINAHL, Psycarticles and Medline). Six relevant articles published between 2011 and 2019 met our inclusion criteria. We extracted information relevant to the nature and outcomes of the reported interventions using thematic content analysis informed by the Population, Intervention, comparison, outcome, and time (PICOT) framework.

Results
Four distinctive treatment modalities that focused on improving ART adherence and retention in care were identified: individual counselling, support groups, family-centered services, and treatment supporters.

Conclusion
There is a dearth of psychosocial support interventions to improve adherence and retention in ART amongst adolescents and young adults living with HIV. Future research and programming should seek to address psychosocial support interventions or approaches specifically designed to address the needs of YPLHIV.

Trial registration
PROSPERO: Registration CRD42018105057.
SARS coronavirus 2: from genome to infectome
Authors: Rastogi Meghana , Pandey Neha , Shukla Astha , Singh Sunit K. 
Published: December 2020

AbstractSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the group of Betacoronaviruses. The SARS-CoV-2 is closely related to SARS-CoV-1 and probably originated either from bats or pangolins. SARS-CoV-2 is an etiological agent of COVID-19, causing mild to severe respiratory disease which escalates to acute respiratory distress syndrome (ARDS) or multi-organ failure. The virus was first reported from the animal market in Hunan, Hubei province of China in the month of December, 2019, and was rapidly transmitted from animal to human and human-to-human. The human-to-human transmission can occur directly or via droplets generated during coughing and sneezing. Globally, around 53.9 million cases of COVID-19 have been registered with 1.31 million confirmed deaths. The people > 60 years, persons suffering from comorbid conditions and immunocompromised individuals are more susceptible to COVID-19 infection. The virus primarily targets the upper and the lower respiratory tract and quickly disseminates to other organs. SARS-CoV-2 dysregulates immune signaling pathways which generate cytokine storm and leads to the acute respiratory distress syndrome and other multisystemic disorders.
Social capital, depressive symptoms, and perceived quality of care among hypertensive patients in primary care
Authors: Li Haitao , Xia Hui , Yi Shijian , Rao Lichang 
Published: December 2020

Abstract
Background
Depression is an important issue in the management of hypertension. However, little attention has been paid to addressing such aspects of psychological health among patients with hypertension. We aimed to estimate the prevalence of depressive symptoms among patients with hypertension in primary care settings and to identify the potential role of social capital in predicting depressive symptoms. The influence of psychological well-being on the perceived quality of hypertensive care was also examined.

Methods
In Shenzhen, China, an on-site cross-sectional study was conducted from March to September 2017. In total, 1046 respondents completed a face-to-face survey interview. We examined the associations between social capital, depressive symptoms, and perceived quality of care.

Results
The results showed that 10.7% of patients with hypertension who attended primary care facilities had depressive symptoms. Two components of social capital—social ties (9.63 vs. 10.67; OR = 1.314, 95% CI 1.165–1.483; P < .001) and trust (3.46 vs. 3.89; OR = 2.535, 95% CI 1.741–3.691; P < .001)—were protective factors for depression among patients with hypertension in primary care settings. We also found that depressive symptoms were negatively associated with perceived quality of care (30.5 vs. 32.5; β = 1.341, 95% CI 0.463–2.219; P = .003)..

Conclusions
We found inverse associations between depressive symptoms and perceived quality of care and between social capital and the occurrence of symptoms of depression. Our findings suggest that strategies addressing both hypertension and depressive symptoms should be implemented to better manage hypertension. Appropriate social interventions should be designed and implemented.
Factors influencing Australian chiropractors who choose not to join national professional associations: a qualitative study
Authors: Innes Stanley I. , Cope Vicki , Young Kenneth J. 
Published: December 2020

AbstractBackgroundProfessional associations (PAs) are perceived to promote their professions and support their members. Despite these advantages, about 1 in 3 Australian chiropractors choose not to belong to either of the two PAs. Our study had two objectives: 1) to explore the views of non-member chiropractors about PAs in general; 2) seek to understand the motivations of non-member Australian chiropractors about not joining a PA.MethodsThis qualitative descriptive study utilised in-depth semi-structured interviews with open-ended questions for thematic analysis and was conducted from January to April 2020. Nine participants were interviewed before no new themes were articulated. Participants had to be registered chiropractors who had not been members of a PA for at least three years. Recruitment was through a Facebook advertisement and snowball sampling. Interviews were transcribed and imported into NVivo qualitative analysis software, allowing identification of key concepts surrounding non-membership of chiropractic PAs.ResultsFive themes were identified. 1) A tarnished image, suggested the profession has a poor standing in the eyes of the public and other health professionals. 2) Not worth the money, expressed the annual membership dues were not viewed as good value for money. 3) Going it alone / what’s in it for me? indicated there was no direct benefit or anything deemed essential for practice. 4) Two warring factions, reflected not wanting to be seen to be part of the internal conflict between conservative and evidence-based practitioners. 5) Lack of visibility, described no visible presence or strong communication that clearly displayed the advantages of membership.ConclusionsNon-members are looking for PAs to enhance the respectability of the profession in a manner that ultimately results in increased patient volume and the provision of readily accessible day-to-day resources and information. These results can inform the construction of a survey for the broader chiropractic non-membership community to confirm and expand upon these findings and potentially improve PAs.
Clinical and radiological results of kyphectomy and sliding growing rod surgery technique performed in children with myelomeningocele
Authors: Özcan Çağrı , Polat Ömer , Alataş İbrahim , Çamur Savaş , Sağlam Necdet , Uçar Bekir Yavuz 
Published: December 2020

AbstractBackgroundThe aim of this study was to present clinical and radiological results of myelomeningocele (MMC) patients treated with the sliding growing rod (SGR) technique after kyphectomy.MethodsBetween 2016 and 2019, 30 patients (21 males and nine females) who underwent the SGR technique with kyphectomy and posterior instrumentation due to MMC were retrospectively reviewed. Patients’ pre- and postoperative kyphosis, scoliosis, correction rates, bleeding during surgery, blood supply during and after surgery, operation time, instrumentation levels, number of vertebrae removed, MMC onset levels, hospital stay, annual lengthening amounts, and complications were evaluated.ResultsThe mean patient age was 6.9 (4–10) years. Mean preoperative kyphosis was 115° (87–166°), mean early postoperative kyphosis was 3.9° (20–10°), and final follow-up postoperative kyphosis was 5.1° (22–8°). In nine patients presenting with scoliosis, scoliosis was evaluated as 60.2° (115–35°) preoperative, as 12.9° (32–0°) early postoperative, and 15.7° (34–0°) in the final measurement. The kyphotic deformity correction rate was 96.5%, and the scoliotic deformity correction rate was 74.9%. A statistically significant difference was seen between pre- and early postoperative values in kyphosis and scoliosis measurements (p< 0.05). The annual prolongation of the patients was calculated as averages of 0.72 and 0.77 cm/year between T1–T12 and T1–S1, respectively.ConclusionKyphectomy performed during the early MMC period patients appears to be an excellent method for facilitating rehabilitation and daily care of these patients. It appears that the SGR technique, which provides lung volume protection and lengthening with kyphectomy, is a safe and reliable method in patients.Level of evidenceLevel 4