bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Integrated Chemiluminescence Microreactor for Ultrastrong and Long‐Lasting Light Emission
Authors: Xiao Zhenyu , Wang Yutong , Xu Ben , Du Shunfu , Fan Weidong , Cao Dongwei , Deng Ying , Zhang Liangliang , Wang Lei , Sun Daofeng 
Published: June 2020

AbstractA porous metal–organic framework [Ba(H2LLOMe 2−)·DMF·H2O]·2DMF (UPC‐2) (H4LLOMe = 4ʹ,4ʹʹʹ‐(2,3,6,7‐tetramethoxyanthracene‐9,10‐diyl)bis([1,1ʹ‐biphenyl]‐3,5‐dicarbo‐xylic acid N,N‐Dimethylformamide [DMF]), which can act as an excellent chemiluminescence microreactor, is designed and constructed. In the framework of UPC‐2, the catalytic Ba cluster and electron‐rich anthracene fluorescent centers are fixed and interconnected in an orderly fashion, and this can shorten the energy transfer path and weaken the relaxation of the chemiluminescence process. Meanwhile, the rhombic channels of UPC‐2 can provide a proper diffusion ratio of reactants to support a stable and continuous energy supply. The UPC‐2 chemiluminescence microreactor exhibits an ultrastrong and long‐lasting light emission, which possesses potential application in emergency lights and biological mapping. The concept of the chemiluminescence microreactor and its construction using a metal–organic framework as a platform will promote further research in the design and fabrication of functional MOFs for chemiluminescence applications.
Near‐IR to Near‐IR Upconversion Luminescence in Molecular Chromium Ytterbium Salts
Authors: Kalmbach Jens , Wang Cui , You Yi , Förster Christoph , Schubert Hartmut , Heinze Katja , Resch‐Genger Ute , Seitz Michael 
Published: June 2020

AbstractUpconversion photoluminescence in hetero‐oligonuclear metal complex architectures featuring organic ligands is an interesting but still rarely observed phenomenon, despite its great potential from a basic research and application perspective. In this context, a new photonic material consisting of molecular chromium(III) and ytterbium(III) complex ions was developed that exhibits excitation‐power density‐dependent cooperative sensitization of the chromium‐centered 2E/2T1 phosphorescence at approximately 775 nm after excitation of the ytterbium band 2F7/2→2F5/2 at approximately 980 nm in the solid state at ambient temperature. The upconversion process is insensitive to atmospheric oxygen and can be observed in the presence of water molecules in the crystal lattice.
Electrospinning superhydrophobic–superoleophilic PVDF‐SiO2 nanofibers membrane for oil–water separation
Authors: Jiang Shan , Meng Xiangfei , Chen Binling , Wang Nannan , Chen Guangkai 
Published: June 2020

AbstractOil–water separation has attracted research interest due to the damages of oily wastewater caused to the environment and human beings. Electrospun fiber membrane has high oil–water separation performance. A nanofibers membrane with multi‐stage roughness was prepared by electrospinning using poly(vinylidene fluoride)(PVDF)‐silica blend solution as raw material. The result shows that the water contact angle (WCA) of the nanofibers membrane was promoted from 138.5 ± 1° to 150.0 ± 1.5° when the SiO2 content was increased from 0 to 3 wt%. The nanofibers membranes exhibited excellent separation efficiency (99 ± 0.1%) under gravity drive, with high separation flux of 1857 ± 101 L·m−2·h−1. More importantly, the obtained PVDF‐SiO2 nanofibers membranes showed excellent multi‐cycle performance and stable chemical resistance, which would make them great advantages for the practical application of oil–water separation.
Persistent Bacteriuria and Antibodies Recognizing Curli/eDNA Complexes From Escherichia coli Are Linked to Flares in Systemic Lupus Erythematosus
Authors: Pachucki Ryan J. , Corradetti Chelsea , Kohler Lynne , Ghadiali Jay , Gallo Paul M. , Nicastro Lauren , Tursi Sarah A. , Gallucci Stefania , Tükel Çagla , Caricchio Roberto 
Published: June 2020

ObjectiveInfections contribute to morbidity and mortality in systemic lupus erythematosus (SLE). Uropathogenic Escherichia coli (UPEC) are known to trigger urinary tract infections (UTIs) and form biofilms, which are multicellular communities of bacteria that are strengthened by amyloids such as curli. We previously reported that curli naturally form complexes with bacterial extracellular DNA (eDNA), and these curli/eDNA complexes induce hallmark features of lupus in mouse models. The present study was undertaken to investigate whether anti–curli/eDNA complex antibodies play a role in the pathogenesis of SLE or development of flares in SLE.MethodsIn total, 96 SLE patients who met at least 4 Systemic Lupus International Collaborating Clinics disease criteria were investigated. Anti–curli/eDNA complex antibodies in the plasma were tested for both IgG and IgA subclasses. Results were compared to that in 54 age‐, sex‐, and race/ethnicity‐matched healthy controls. Correlations of the levels of anti‐curli/eDNA antibodies with clinical parameters, lupus disease status, and frequency of bacteriuria were assessed.ResultsAnti‐curli/eDNA antibodies were detected in the plasma of SLE patients and healthy controls, and their levels correlated with the presence of asymptomatic persistent bacteriuria and occurrence of disease flares in lupus patients. Persistent bacteriuria contained curli‐producing UPEC, and this was associated with an inflammatory phenotype. Finally, curli/eDNA complexes cross‐reacted with lupus autoantigens, such as double‐stranded DNA, in binding autoantibodies.ConclusionThese results suggest that UTIs and persistent bacteriuria are environmental triggers of lupus and its flares. Antibodies against curli/eDNA could serve as a sign of systemic exposure to bacterial products in SLE.
Clickable artificial heme‐peroxidases for the development of functional nanomaterials
Authors: Zambrano Gerardo , Chino Marco , Renzi Emilia , Di Girolamo Rocco , Maglio Ornella , Pavone Vincenzo , Lombardi Angela , Nastri Flavia 
Published: June 2020

AbstractArtificial metalloenzymes as catalysts are promising candidates for their use in different technologies, such as bioremediation, biomass transformation, or biosensing. Despite this, their practical exploitation is still at an early stage. Immobilized natural enzymes have been proposed to enhance their applicability. Immobilization may offer several advantages: (i) catalyst reuse; (ii) easy separation of the enzyme from the reaction medium; (iii) better tolerance to harsh temperature and pH conditions. Here, we report an easy immobilization procedure of an artificial peroxidase on different surfaces, by means of click chemistry. FeMC6*a, a recently developed peroxidase mimic, has been functionalized with a pegylated aza‐dibenzocyclooctyne to afford a “clickable” biocatalyst, namely FeMC6*a‐PEG4@DBCO, which easily reacts with azide‐functionalized molecules and/or nanomaterials to afford functional bioconjugates. The clicked biocatalyst retains its structural and, to some extent, its functional behaviors, thus housing high potential for biotechnological applications.
Promoting P450 BM3 heme domain dimerization with a tris(5‐iodoacetamido‐1,10‐phenanthroline)Ru(II) complex
Authors: Kato Mallory , Foley Bridget , Vu Julia , Huynh Michael , Lucero Kathreena , Harmon Caroline , Cheruzel Lionel 
Published: June 2020

AbstractProtein dimerization often occurs in many biological systems as to provide structural and functional advantages. A tris(5‐iodoacetamido‐1,10‐phenanthroline)Ruthenium(II) complex was shown to promote the covalent dimerization of a P450 BM3 heme domain mutant containing a surface‐exposed nonnative single cysteine residue. The formation of homodimeric species was confirmed by protein gel electrophoresis, mass spectrometry and UV–Vis spectroscopy. The dimeric species could be separated from the monomer and aggregates by size‐exclusion chromatography. Docking simulation reveals a plausible structure with two proteins covalently conjugated to the inorganic compound.
Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract‐based spatial statistics study
Authors: Liu Yu‐Xin , Li Biao , Wu Kang‐Rui , Tang Li‐Ying , Lin Qi , Li Qing‐Hai , Yuan Qing , Shi Wen‐Qing , Liang Rong‐Bin , Ge Qian‐Min , Shao Yi 
Published: June 2020

AbstractBackgroundVisual deprivation can lead to abnormal and plastic changes in the brain's visual system and other systems. Although the secondary changes of gray matter in patients have been well studied, the study of white matter is rare. In fact, subtle changes in white matter may be revealed by diffusion tensor imaging, and tract‐based spatial statistics can be used to analyze DTI image data.PurposeIn the present study, diffusion tensor imaging (DTI) and tract‐based spatial statistics (TBSS) were used to investigate abnormal structural changes in the white matter (WM) of patients with monocular blindness (MB).MethodsWe recruited 16 healthy controls (HC) (fourteen males and two females) and 16 patients (fifteen males and one female) with right‐eye blindness (without differences in left‐eye vision). All patients were of similar age. Data acquisition was performed using magnetic resonance imaging (MRI) and DTI. Voxel‐based whole brain comparisons of fractional anisotropy (FA) and radial diffusivity (RD) of WM fibers in patients and HC were performed using the TBSS method. The mean FA and RD values for altered brain regions in MB patients were analyzed via the receiver operating characteristic (ROC) curve. Correlation analysis was performed to investigate the relationships between the average FA (RD) value of the whole brain and anxiety score, depression score, and visual function questionnaire score in MB patients.ResultsIn MB patients, the mean FA of the whole brain was decreased versus HC. Moreover, the FA values of the corpus callosum, the corona radiata, the posterior thalamic radiation, and the right retrolenticular part of internal capsule were significantly decreased. In addition, the average RD value of the whole brain in MB patients was higher than that observed in HC. The mean FA and RD values of brain regions were analyzed using the ROC curve, and the results showed that the area under the ROC curve was more accurate. Furthermore, the average FA and RD values of the whole brain were significantly correlated with anxiety score, depression score, and visual function‐related quality of life score.ConclusionDTI and TBSS may be useful in examining abnormal spontaneous alterations in the WM of MB patients. The observed changes in FA and RD values may imply the larvaceous neurological mechanism involved in MB.
Total Tocopherols, Carotenoids, and Fatty Acids Content Variation of Pistacia atlantica from Different Organs’ Crude Oils and Their Antioxidant Activity during Development Stages
Authors: Chelghoum Manel , Guenane Hamid , Harrat Mohamed , Yousfi Mohamed 
Published: June 2020

AbstractThe current study investigated the effect of developmental stages on the chemical composition and the antioxidant activity of fifteen crude oil samples obtained from Pistacia atlantica Desf. leaves, galls, and fruits. Twelve fatty acids were detected by GC/FID, linolenic acid (C18 : 3) was the major fatty acid detected in leaves crude oils that registered [41.73 % (P<0.05)] on the last stage. The best content of tocopherols and carotenoids was recorded at the last stage for leaves and galls oils, respectively, with values of [1.530±0.01, 0.52±0.01 (P<0.05) mg α‐tocopherol equivalent/g DW] and [86.60±0.95, 69.15±0.13 (P<0.05) μg β‐carotene equivalent/g DW]. For fruits oils, the content varied depending on the levels of fruits maturation. The results from DPPH, FRAP, and ABTS assays revealed that the antioxidant activity increased with the increasing content of tocopherols and carotenoids in leaves and galls oils during development stages, and varied for fruits oils depending on the ripening stages. Moreover, according to PCA analysis, the best phytoconstituent content and antioxidant activity were attributed to P. atlantica Desf. fruit's crude oils. Also, a strong relationship was found between the antioxidant activity and bioactive phytochemical components, such as tocopherols, carotenoids, and omega‐three fatty acid, which confirmed that P. atlantica Desf. crude oils present a valuable source of natural antioxidant that could be used for pharmaceutical and food industries purposes.
Predictors of patent and occlusive hemostasis after transradial coronary procedures
Authors: Pacchioni Andrea , Bellamoli Michele , Mugnolo Antonio , Ferro Jayme , Pesarini Gabriele , Turri Riccardo , Ribichini Flavio , Saccà Salvatore , Versaci Francesco , Reimers Bernhard 
Published: June 2020

AbstractObjectivesTo assess the independent predictors of patent and occlusive hemostasis (PH and OH, respectively) during radial hemostasis after coronary procedures.BackgroundRadial artery occlusion (RAO) is a thrombotic complication of transradial catheterization that can lead to permanent occlusion of the radial artery. Sheath‐vessel diameter ratio, postprocedure compression time, occlusive hemostasis, inadequate, and excessive anticoagulation are all predictors of RAO.MethodsAs a part of a previously published study investigating the relationship between residual anticoagulation and risk of RAO, 837 patients undergoing transradial diagnostic coronary angiography or percutaneous coronary interventions were enrolled. Cumulative heparin dose used during the procedure and ACT measured before sheath removal were recorded. PH with reverse Barbeau test was attempted in all patients (NCT02762344).ResultsPH was less frequently obtained for increasing cumulative heparin dose and ACT values (p < .0001 and p = .0034, respectively). At logistic regression analysis both cumulative heparin dose and ACT values were independent predictors of OH (OR 1.017, 95% IC 1.011–1.023 p < .0001 and OR 1.004, 95% IC 1.001–1.006, p = .0004) while adjusted probability for RAO showed exponential relationship with both parameters.ConclusionsThe level of anticoagulation is strongly related to the incidence of RAO, and should be taken into account when choosing hemostasis protocol.
Functional Micro/Nanoreactors for Nanospace‐Confined Migrations and Diffusions
Authors: Wang Xinyao , Liu Jian 
Published: June 2020

AbstractDiffusion is a natural phenomenon and essential in many fields. Conceptually, diffusion in solid materials, especially in the confined micro/nano‐spaces, can boost the development of new functional nanomaterials for applications across a range of areas. In this Minireview, we categorize the diffusion behavior at the nanoscale including atom/ion diffusion and direct migration of nanoparticles, and discuss how these two strategies can be applied for the construction of nanoreactors with unique structures and components. The understanding of diffusion principles in a confined system is summarized in detail. Moreover, the development opportunities of diffusion process in future research are outlined.
Following the Ground States of Full‐RSB Spherical Spin Glasses
Authors: Subag Eliran 
Published: June 2020

We focus on spherical spin glasses whose Parisi distribution has support of the form [0, q]. For such models we construct paths from the origin to the sphere that consistently remain close to the ground‐state energy on the sphere of corresponding radius. The construction uses a greedy strategy, which always follows a direction corresponding to the most negative eigenvalues of the Hessian of the Hamiltonian. For finite mixtures ξ(x) it provides an algorithm of time complexity O(Ndeg(ξ)) to find w.h.p. points with the ground‐state energy, up to a small error.For the pure spherical models, the same algorithm reaches the energy −E∞, the conjectural terminal energy for gradient descent. Using the TAP formula for the free energy, for full‐RSB models with support [0, q], we are able to prove the correct lower bound on the free energy (namely, prove the lower bound from Parisi's formula), assuming the correctness of the Parisi formula only in the replica symmetric case. © 2020 Wiley Periodicals LLC
Lumped Parameter Model for Silicon Crystal Growth from Granulate Crucible
Authors: Lorenz‐Meyer M. Nicolai L. , Menzel Robert , Dadzis Kaspars , Nikiforova Angelina , Riemann Helge 
Published: June 2020

AbstractIn the present paper, a lumped parameter model for the novel Silicon Granulate Crucible (SiGC) method is proposed, which is the basis for a future model‐based control system for the process. The model is analytically deduced based on the hydromechanical, geometrical, and thermal conditions of the process. Experiments are conducted to identify unknown model parameters and to validate the model. The physical consistency of the model is verified using simulation studies and a prediction error of below 2% is reached.
Ginsenoside Rg3 attenuates ovariectomy‐induced osteoporosis via AMPK/mTOR signaling pathway
Authors: Zhang Xiaonan , Huang Fenglan , Chen Xiaoyong , Wu Xiaoqing , Zhu Jinyu 
Published: June 2020

AbstractGinsenoside Rg3, a ginsenoside isolated from Panax ginseng, can regulate autophagy via AMP‐activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway. AMPK/mTOR signaling and autophagy have been reported to be involved in osteogenesis. Here, the effect of Rg3 on ovariectomy (OVX)‐induced osteoporosis is explored. In vivo, rats were treated with 20 mg/kg Rg3 after OVX and the body weight (BW) was monitored. Bone mineral density (BMD), hematoxylin–eosin staining of femur tissues, osteogenesis, autophagy, and AMPK/mTOR signaling were analyzed. In vitro, MC3T3‐E1 cells were treated with 0, 1, 5, 10, 20, and 100 μmol/L Rg3. 10 and 20 μmol/L Rg3, which had no significant effect on cell viability and significantly affected AMPK/mTOR signaling, were chosen for further analysis. Then osteogenic differentiation was induced with Rg3 or/and AMPK inhibitor (Compound C). AMPK/mTOR signaling, autophagy, osteogenic differentiation, and mineralization by Alizarin Red staining were analyzed. The expression or activity of AMPK/mTOR signaling‐related proteins, autophagy markers, and osteogenesis markers was measured by western blotting or commercial kits, and cell viability by cell counting kit‐8 assay kits. Rg3 significantly alleviated OVX‐induced BW increases, BMD declines and histological changes of femur tissues, promoted osteogenesis, autophagy, and AMPK signaling, but inhibited mTOR signaling in vivo. Moreover, Rg3 significantly enhanced AMPK signaling, autophagy, osteogenic differentiation, and mineralization, but suppressed mTOR signaling in vitro. However, Compound C significantly reversed Rg3‐induced alterations in vitro, indicating that Rg3 regulated autophagy, osteogenic differentiation, and mineralization via AMPK/mTOR signaling. Hence, it was speculated that Rg3 might attenuate OVX‐induced osteoporosis via AMPK/mTOR signaling pathway.
Discovery and Characterization of Novel Naphthalimide Analogs as Potent Multitargeted Directed Ligands against Alzheimer's Disease
Authors: Gao Jie , Chapman James 
Published: June 2020

AbstractCurrent therapeutic drugs for Alzheimer's disease (AD) can only offer limited symptomatic benefits and do not halt disease progression. Multitargeted directed ligands (MTDLs) have been considered to be a feasible way to treat AD due to the multiple neuropathological processes in AD. Previous studies proposed that compounds containing two aromatic groups connected by a carbon chain should act as effective amyloid β (Aβ) aggregation inhibitors although the optimal length of the carbon chain has not been explored. In the current study, a series of naphthalimide analogs were designed and synthesized based on the proposed structure and multiple bioactivities beneficial to the AD treatment were reported. In vitro studies showed that compound 8, which has two aromatic groups connected by a two‐carbon chain, exhibited significant inhibition of Aβ aggregation through the prevention of elongation and association of Aβ fibril growth. Furthermore, this compound also displayed antioxidative activities and neuroprotection from Aβ monomer induced toxicity in primary cortical neurons. The results of the present study highlight a novel naphthalimide‐based compound 8 as a promising MTDL against AD. Its structural elements can be further explored for enhanced therapeutic capabilities.
“New” cyanobacterial blooms are not new: two centuries of lake production are related to ice cover and land use
Authors: Ewing Holly A. , Weathers Kathleen C. , Cottingham Kathryn L. , Leavitt Peter R. , Greer Meredith L. , Carey Cayelan C. , Steele Bethel G. , Fiorillo Alyeska U. , Sowles John P. 
Published: June 2020

AbstractRecent cyanobacterial blooms in otherwise unproductive lakes may be warning signs of impending eutrophication in lakes important for recreation and drinking water, but little is known of their historical precedence or mechanisms of regulation. Here, we examined long‐term sedimentary records of both general and taxon‐specific trophic proxies from seven lakes of varying productivity in the northeastern United States to investigate their relationship to historical in‐lake, watershed, and climatic drivers of trophic status. Analysis of fossil pigments (carotenoids and chlorophylls) revealed variable patterns of past primary production across lakes over two centuries despite broadly similar changes in regional climate and land use. Sediment abundance of the cyanobacterium Gloeotrichia, a large, toxic, nitrogen‐fixing taxon common in recent blooms in this region, revealed that this was not a new taxon in the phytoplankton communities but rather had been present for centuries. Histories of Gloeotrichia abundance differed strikingly across lakes and were not consistently associated with most other sediment proxies of trophic status. Changes in ice cover most often coincided with changes in fossil pigments, and changes in watershed land use were often related to changes in Gloeotrichia abundance, although no single climatic or land‐use factor was associated with proxy changes across all seven lakes. The degree to which changes in lake sediment records co‐occurred with changes in the timing of ice‐out or agricultural land use was negatively correlated with the ratio of watershed area to lake area. Thus, both climate and land management appeared to play key roles in regulation of primary production in these lakes, although the manner in which these factors influenced lakes was mediated by catchment morphometry. Improved understanding of the past interactions between climate change, land use, landscape setting, and water quality underscores the complexity of mechanisms regulating lake and cyanobacterial production and highlights the necessity of considering these interactions—rather than searching for a singular mechanism—when evaluating the causes of ongoing changes in low‐nutrient lakes.