bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
Authors: Berti Matteo , Teloni Federico , Mijic Sofija , Ursich Sebastian , Fuchs Jevgenij , Palumbieri Maria Dilia , Krietsch Jana , Schmid Jonas A. , Garcin Edwige B. , Gon Stéphanie , Modesti Mauro , Altmeyer Matthias , Lopes Massimo 
Published: July 2020

AbstractHomologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, HR-mediated fork remodeling promotes cancer chemoresistance, by as-yet elusive mechanisms. Five HR cofactors – the RAD51 paralogs RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 – recently emerged as crucial tumor suppressors. Albeit extensively characterized in DNA repair, their role in replication has not been addressed systematically. Here, we identify all RAD51 paralogs while screening for modulators of RAD51 recombinase upon replication stress. Single-molecule analysis of fork progression and architecture in isogenic cellular systems shows that the BCDX2 subcomplex restrains fork progression upon stress, promoting fork reversal. Accordingly, BCDX2 primes unscheduled degradation of reversed forks in BRCA2-defective cells, boosting genomic instability. Conversely, the CX3 subcomplex is dispensable for fork reversal, but mediates efficient restart of reversed forks. We propose that RAD51 paralogs sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart.
Attentional priorities drive effects of time pressure on altruistic choice
Authors: Teoh Yi Yang , Yao Ziqing , Cunningham William A. , Hutcherson Cendri A. 
Published: July 2020

AbstractDual-process models of altruistic choice assume that automatic responses give way to deliberation over time, and are a popular way to conceptualize how people make generous choices and why those choices might change under time pressure. However, these models have led to conflicting interpretations of behaviour and underlying psychological dynamics. Here, we propose that flexible, goal-directed deployment of attention towards information priorities provides a more parsimonious account of altruistic choice dynamics. We demonstrate that time pressure tends to produce early gaze-biases towards a person’s own outcomes, and that individual differences in this bias explain how individuals’ generosity changes under time pressure. Our gaze-informed drift-diffusion model incorporating moment-to-moment eye-gaze further reveals that underlying social preferences both drive attention, and interact with it to shape generosity under time pressure. These findings help explain existing inconsistencies in the field by emphasizing the role of dynamic attention-allocation during altruistic choice.
Tuning the hysteresis of a metal-insulator transition via lattice compatibility
Authors: Liang Y. G. , Lee S. , Yu H. S. , Zhang H. R. , Liang Y. J. , Zavalij P. Y. , Chen X. , James R. D. , Bendersky L. A. , Davydov A. V. , Zhang X. H. , Takeuchi I. 
Published: July 2020

AbstractStructural phase transitions serve as the basis for many functional applications including shape memory alloys (SMAs), switches based on metal-insulator transitions (MITs), etc. In such materials, lattice incompatibility between transformed and parent phases often results in a thermal hysteresis, which is intimately tied to degradation of reversibility of the transformation. The non-linear theory of martensite suggests that the hysteresis of a martensitic phase transformation is solely determined by the lattice constants, and the conditions proposed for geometrical compatibility have been successfully applied to minimizing the hysteresis in SMAs. Here, we apply the non-linear theory to a correlated oxide system (V1−xWxO2), and show that the hysteresis of the MIT in the system can be directly tuned by adjusting the lattice constants of the phases. The results underscore the profound influence structural compatibility has on intrinsic electronic properties, and indicate that the theory provides a universal guidance for optimizing phase transforming materials.
ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
Authors: Au-Yeung Chi-Lam , Yeung Tsz-Lun , Achreja Abhinav , Zhao Hongyun , Yip Kay-Pong , Kwan Suet-Ying , Onstad Michaela , Sheng Jianting , Zhu Ying , Baluya Dodge L. , Co Ngai-Na , Rynne-Vidal Angela , Schmandt Rosemarie , Anderson Matthew L. , Lu Karen H. , Wong Stephen T. C. , Nagrath Deepak , Mok Samuel C. 
Published: July 2020

AbstractAdvanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrate that ITLN1 suppresses lactotransferrin’s effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells. Additionally, ovarian cancer-bearing mice treated with ITLN1 demonstrate marked decrease in tumor growth rates. These data suggest that downregulation of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progression.
Flash sintering incubation kinetics
Authors: Vikrant K.S.N. , Wang Han , Jana Aniruddha , Wang Haiyan , García R. Edwin 
Published: July 2020

AbstractThe microstructural mechanisms leading to onset of the flash sintering are demonstrated experimentally and theoretically for Yttria Stabilized Zirconia, YSZ. Three regimes leading to flash event are identified: (1) Radiation-dominated regime, where the oven controls the heating of the sintered sample, and a small subset of particle-particle contacts and surfaces of the green body define percolative paths for the charge to flow along and across the interfaces; (2) Transition regime, where charge transport is suppressed across particle contact misorientations and deflects to surficial and small angle particle contact misorientations. As a result, internal Joule heating takes over externally-driven radiation heating. Finally, (3) Percolative regime, where the concentration of oxygen vacancies drastically increases at particle contacts, surfaces, and triple junctions, and enables charge to flow through multiple paths, generating large amounts of Joule heating, resulting in the onset of a flash event. The validated theory sets the stage to rationalize the microstructural evolution and charge transport on a ceramic green body during flash sintering.
Blood pressure-lowering effects of a Bowman-Birk inhibitor and its derived peptides in normotensive and hypertensive rats
Authors: de Freitas Maria Alzira Garcia , Amaral Nathalia Oda , Álvares Alice da Cunha Morales , de Oliveira Sandriele Aires , Mehdad Azadeh , Honda Diego Elias , Bessa Amanda Sá Martins , Ramada Marcelo Henrique Soller , Naves Lara Marques , Pontes Carolina Nobre Ribeiro , Castro Carlos Henrique , Pedrino Gustavo Rodrigues , de Freitas Sonia Maria 
Published: July 2020

AbstractBioactive plant peptides have received considerable interest as potential antihypertensive agents with potentially fewer side effects than antihypertensive drugs. Here, the blood pressure-lowering effects of the Bowman-Birk protease inhibitor, BTCI, and its derived peptides, PepChy and PepTry, were investigated using normotensive (Wistar-WR) and spontaneously hypertensive rats (SHR). BTCI inhibited the proteases trypsin and chymotrypsin, respectively, at 6 µM and 40 µM, a 10-fold greater inhibition than observed with PepTry (60 µM) and PepChy (400 µM). These molecules also inhibited angiotensin converting enzyme (ACE) with IC50 values of 54.6 ± 2.9; 24.7 ± 1.1; and 24.4 ± 1.1 µM, respectively, occluding its catalytic site, as indicated by molecular docking simulation, mainly for PepChy and PepTry. Gavage administration of BTCI and the peptides promoted a decrease of systolic and diastolic blood pressure and an increase of renal and aortic vascular conductance. These effects were more expressive in SHR than in WR. Additionally, BTCI, PepChy and PepTry promoted coronary vasodilation and negative inotropic effects in isolated perfused hearts. The nitric oxide synthase inhibitor blunted the BTCI and PepChy, with no cardiac effects on PepTry. The findings of this study indicate a therapeutic potential of BTCI and its related peptides in the treatment of hypertension.
Mid and long-term ecological impacts of ski run construction on alpine ecosystems
Authors: Hudek Csilla , Barni Elena , Stanchi Silvia , D’Amico Michele , Pintaldi Emanuele , Freppaz Michele 
Published: July 2020

AbstractThe proliferation of ski run construction is a worldwide trend. The machine-grading of slopes involved during ski run construction changes the physical, chemical and biological properties of the soil, having significant long-term ecological impact on the environment. Establishing and developing plant communities in these affected areas is crucial in rehabilitating the biotic and abiotic soil environment, while also improving slope stability and reducing the risk of natural hazards. This study evaluates changes in plant-soil properties and the long-term effects of machine-grading and subsequent restoration of ski runs so as to contribute to formulating the best practices in future ski run constructions. Study plots were established in 2000 and re-surveyed in 2017 on ski runs, which had been machine-graded and hydroseeded in the 1990s. Vegetation, root trait and soil surveys were carried out on ski run plots and compared to paired, undisturbed control sites off the ski runs. Plant cover remained unchanged on the ski-runs over time but plant richness and diversity considerably increased, reaching similar levels to undisturbed vegetation. Plant composition moved towards more semi-natural stages, showing a reduction in seeded plants with a comparable increase in the cover of colonizing native species. Root trait results were site-specific showing great variations between the mid and long-term after-effects of machine-grading and revegetation when compared to undisturbed sites. Under long-term management, the soil pH was still higher and the organic C content still lower in the ski runs than in the undisturbed sites, as the aggregate stability. The standard actions applied (machine-grading, storage and re-use of topsoil, hydroseeding of commercial seed mixtures, application of manure soon after seeding and low-intensity grazing) allowed the ecosystem to partially recover in three decades, and even if the soil has still a lower chemical and physical fertility than the undisturbed sites, the plant species composition reveals a satisfactory degree of renaturalization.
The dynamics of large silicic systems from satellite remote sensing observations: the intriguing case of Domuyo volcano, Argentina
Authors: Lundgren Paul , Girona Társilo , Bato Mary Grace , Realmuto Vincent J. , Samsonov Sergey , Cardona Carlos , Franco Luis , Gurrola Eric , Aivazis Michael 
Published: July 2020

AbstractSilicic magmatic systems are the most dangerous volcanoes on Earth, capable of large and catastrophic eruptions, yet their low eruptive frequency makes it challenging to interpret their short-term unrest. Here we present a decade-plus analysis that integrates, for the first time, time series of satellite interferometric synthetic aperture radar (InSAR) surface deformation and satellite thermal infrared edifice-scale surface warming at a large silicic system: Domuyo volcano, in Argentina. We find that deformation and warming are highly correlated, and depending on the sign and lag between the time series, either shallow sealing or magma influx could drive Domuyo’s ongoing inflation (~ 0.15 m/year; from an InSAR-derived tabular source, ~ 11 × 8 × 1 km; ~ 6.5 km depth; ~ 0.037 km3/year volume-change rate) and warming (0.3–0.4 °C/year). This study shows the potential that combined satellite surface deformation and edifice-scale surface warming time series have on assessing the physical mechanisms of silicic volcanic systems and for constraining deterministic models.
Unconditionally secured classical cryptography using quantum superposition and unitary transformation
Authors: Ham Byoung S. 
Published: July 2020

AbstractOver decades quantum cryptography has been intensively studied for unconditionally secured key distribution in a quantum regime. Due to the quantum loopholes caused by imperfect single photon detectors and/or lossy quantum channels, however, the quantum cryptography is practically inefficient and even vulnerable to eavesdropping. Here, a method of unconditionally secured key distribution potentially compatible with current fiber-optic communications networks is proposed in a classical regime for high-speed optical backbone networks. The unconditional security is due to the quantum superposition-caused measurement indistinguishability between paired transmission channels and its unitary transformation resulting in deterministic randomness corresponding to the no-cloning theorem in a quantum key distribution protocol.
Soft-sensor modeling for l-lysine fermentation process based on hybrid ICS-MLSSVM
Authors: Wang Bo , Shahzad Muhammad , Zhu Xianglin , Ur Rehman Khalil , Ashfaq Muhammad , Abubakar Muhammad 
Published: July 2020

AbstractThe l-lysine fermentation process is a complex, nonlinear, dynamic biochemical reaction process with multiple inputs and multiple outputs. There is a complex nonlinear dynamic relationship between each state variable. Some key variables in the fermentation process that directly reflect the quality of the fermentation cannot be measured online in real-time which greatly limits the application of advanced control technology in biochemical processes. This work introduces a hybrid ICS-MLSSVM soft-sensor modeling method to realize the online detection of key biochemical variables (cell concentration, substrate concentration, product concentration) of the l-lysine fermentation process. First of all, a multi-output least squares support vector machine regressor (MLSSVM) model is constructed based on the multi-input and multi-output characteristics of l-lysine fermentation process. Then, important parameters ($$\gamma$$γ, $$\lambda$$λ, $$\sigma$$σ) of MLSSVM model are optimized by using the Improved Cuckoo Search (ICS) optimization algorithm. In the end, the hybrid ICS-MLSSVM soft-sensor model is developed by using optimized model parameter values, and the key biochemical variables of the l-lysine fermentation process are realized online. The simulation results confirm that the proposed regression model can accurately predict the key biochemical variables. Furthermore, the hybrid ICS-MLSSVM soft-sensor model is better than the MLSSVM soft-sensor model based on standard CS (CS-MLSSVM), particle swarm optimization (PSO) algorithm (PSO-MLSSVM) and genetic algorithm (GA-MLSSVM) in prediction accuracy and adaptability.
Oral anticoagulants and risk of acute liver injury in patients with nonvalvular atrial fibrillation: a propensity-weighted nationwide cohort study
Authors: Maura Géric , Bardou Marc , Billionnet Cécile , Weill Alain , Drouin Jérôme , Neumann Anke 
Published: July 2020

AbstractInsufficient real-world data on acute liver injury (ALI) risk associated with oral anticoagulants (OACs) exist in patients with nonvalvular atrial fibrillation (NVAF). Using the French national healthcare databases, a propensity-weighted nationwide cohort study was performed in NVAF patients initiating OACs from 2011 to 2016, considering separately those (1) with no prior liver disease (PLD) as main population, (2) with PLD, (3) with a history of chronic alcoholism. A Cox proportional hazards model was used to estimate the hazard ratio with 95% confidence interval (HR [95% CI]) of serious ALI (hospitalised ALI or liver transplantation) during the first year of treatment, for each non-vitamin K antagonist (VKA) oral anticoagulant (NOAC: dabigatran, rivaroxaban, apixaban) versus VKA. In patients with no PLD (N = 434,015), only rivaroxaban new users were at increased risk of serious ALI compared to VKA initiation (adjusted HR: 1.41 [1.05–1.91]). In patients with chronic alcoholism history (N = 13,173), only those initiating dabigatran were at increased risk of serious ALI compared to VKA (2.88 [1.74–4.76]) but an ancillary outcome suggested that differential clinical follow-up between groups might partly explain this association. In conclusion, this study does not suggest an increase of the 1-year risk of ALI in NOAC versus VKA patients with AF.
Infrared photodetector sensitized by InAs quantum dots embedded near an Al0.3Ga0.7As/GaAs heterointerface
Authors: Murata Takahiko , Asahi Shigeo , Sanguinetti Stefano , Kita Takashi 
Published: July 2020

AbstractMid-infrared sensors detect infrared radiation emitted from objects, and are actually widely used for monitoring gases and moisture as well as for imaging objects at or above room temperature. Infrared photodetectors offer fast detection, but many devices cannot provide high responsivity at room temperature. Here we demonstrate infrared sensing with high responsivity at room temperature. The central part of our device is an Al0.3Ga0.7As/GaAs heterostructure containing InAs quantum-dot (QD) layer with a 10-nm-thick GaAs spacer. In this device, the electrons that have been accumulated at the heterointerface are transferred to the conduction band of the Al0.3Ga0.7As barrier by absorbing infrared photons and the following drift due to the electric field at the interface. These intraband transitions at the heterointerface are sensitized by the QDs, suggesting that the presence of the QDs increases the strength of the intraband transition near the heterointerface. The room-temperature responsivity spectrum exhibits several peaks in the mid-infrared wavelength region, corresponding to transitions from the InAs QD and wetting layer states as well as the transition from the quantized state of the triangular potential well at the two-dimensional heterointerface. We find that the responsivity is almost independent of the temperature and the maximum value at 295 K is 0.8 A/W at ~ 6.6 µm for a bias of 1 V, where the specific detectivity is $$1.8\times {10}^{10}$$1.8×1010 cmHz1/2/W.
Self-focused attention enhances tactile sensitivity in women at risk from eating disorders
Authors: Sacchetti Sofia , Mirams Laura , McGlone Francis , Cazzato Valentina 
Published: July 2020

AbstractWe examined whether alterations in body perception in EDs extend to the integration of exteroceptive visual and tactile information. Moreover, we investigated the effect of self-focused attention on the ability to correctly detect tactile stimuli. Twenty-seven women reporting low ED symptoms, versus 26 women reporting high ED symptoms, undertook a modified version of the Somatic Signal Detection Task (SSDT), which involved detecting tactile stimuli on the cheek in the presence or absence of a concomitant light. The SSDT was completed while looking at a photograph of one’s own face, another female face, and a scrambled face. Heart rate and skin conductance were recorded continuously during the SSDT. Although ED symptoms were not associated with an overall increased tendency to misperceive touch in the presence of a light, High ED participants were differentially affected by self-focused attention. For the High ED group, physiological arousal, and tactile sensitivity (d′) were increased when self-focused attention was augmented. For the Low ED group, sensitivity (d′) and physiological arousal were higher in the control conditions. We suggest that in those with High ED symptoms, attention to the bodily self may exacerbate a predisposition to focusing on external rather than internal bodily information.
Antimicrobial resistance and virulence of Pseudomonas spp. among healthy animals: concern about exolysin ExlA detection
Authors: Ruiz-Roldán Lidia , Rojo-Bezares Beatriz , de Toro María , López María , Toledano Paula , Lozano Carmen , Chichón Gabriela , Alvarez-Erviti Lydia , Torres Carmen , Sáenz Yolanda 
Published: July 2020

AbstractPseudomonas is a ubiquitous genus that also causes human, animal and plant diseases. Most studies have focused on clinical P. aeruginosa strains from humans, but they are scarce on animal strains. This study was aimed to determine the occurrence of Pseudomonas spp. among faecal samples of healthy animals, and to analyse their antimicrobial resistance, and pathogenicity. Among 704 animal faecal samples analysed, 133 Pseudomonas spp. isolates (23 species) were recovered from 46 samples (6.5%), and classified in 75 different PFGE patterns. Low antimicrobial resistance levels were found, being the highest to aztreonam (50.3%). Five sequence-types (ST1648, ST1711, ST2096, ST2194, ST2252), two serotypes (O:3, O:6), and three virulotypes (analysing 15 virulence and quorum-sensing genes) were observed among the 9 P. aeruginosa strains. Type-3-Secretion System genes were absent in the six O:3-serotype strains that additionally showed high cytotoxicity and produced higher biofilm biomass, phenazine pigments and motility than PAO1 control strain. In these six strains, the exlAB locus, and other virulence genotypes (e.g. RGP69 pathogenicity island) exclusive of PA7 outliers were detected by whole genome sequencing. This is the first description of the presence of the ExlA exolysin in P. aeruginosa from healthy animals, highlighting their pathological importance.
Usefulness of three-dimensional printing of superior mesenteric vessels in right hemicolon cancer surgery
Authors: Chen Yigang , Bian Linjie , Zhou Hong , Wu Danping , Xu Jie , Gu Chen , Fan Xinqi , Liu Zhequn , Zou Junyi , Xia Jiazeng , Xu Zekuan 
Published: July 2020

AbstractThe anatomy of the superior mesenteric vessels is complex, yet important, for right-sided colorectal surgery. The usefulness of three-dimensional (3D) printing of these vessels in right hemicolon cancer surgery has rarely been reported. In this prospective clinical study, 61 patients who received laparoscopic surgery for right hemicolon cancer were preoperatively randomized into 3 groups: 3D-printing (20 patients), 3D-image (19 patients), and control (22 patients) groups. Surgery duration, bleeding volume, and number of lymph node dissections were designed to be the primary end points, whereas postoperative complications, post-operative flatus recovery time, duration of hospitalization, patient satisfaction, and medical expenses were designed to be secondary end points. To reduce the influence of including different surgeons in the study, the surgical team was divided into 2 groups based on surgical experience. The duration of surgery for the 3D-printing and 3D-image groups was significantly reduced (138.4 ± 19.5 and 154.7 ± 25.9 min vs. 177.6 ± 24.4 min, P = 0.000 and P = 0.006), while the number of lymph node dissections for the these 2 groups was significantly increased (19.1 ± 3.8 and 17.6 ± 3.9 vs. 15.8 ± 3.0, P = 0.001 and P = 0.024) compared to the control group. Meanwhile, the bleeding volume for the 3D-printing group was significantly reduced compared to the control group (75.8 ± 30.4 mL vs. 120.9 ± 39.1 mL, P = 0.000). Moreover, patients in the 3D-printing group reported increased satisfaction in terms of effective communication compared to those in the 3D-image and control groups. Medical expenses decreased by 6.74% after the use of 3D-printing technology. Our results show that 3D-printing technology could reduce the duration of surgery and total bleeding volume and increase the number of lymph node dissections. 3D-printing technology may be more helpful for novice surgeons.Trial registration: Chinese Clinical Trial Registry, ChiCTR1800017161. Registered on 15 July 2018.