bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamic relationship between state mindfulness and negative emotions
Authors: Zhou Linli , Zhang Ning , Zhou Yuyang , Xu Wei 
Published: September 2020

AbstractThe current study examines the dynamic influence of state mindfulness on negative emotions in daily life, and we developed two models to investigate their dynamic relationship after controlling the role of perceived stress. One hundred participants recruited from a Chinese university reported their daily and momentary emotions and their levels of state mindfulness five times per day for an entire week. Participants provided 3,177 valid responses, accounting for 90.77% of all required responses. Using a multilevel model, we found that (a) state mindfulness at Time t + 1 mediated the association between negative emotions at t and at t + 2, and the negative emotions encompasses three aspects (anxiety, depression, and sadness), and (b) negative emotion at t + 1 significantly mediated the association between state mindfulness at t and at t + 2. The current study showed that state mindfulness and negative emotions could reciprocally weaken each other, meaning that they demonstrate a counterproductive relationship.
Genotypes versus phenotypes: The potential paradigm shift in the diagnosis and management of pediatric neoplasms
Authors: Chi‐Fung Chan Godfrey , Matias Chan Carol 
Published: September 2020

AbstractThe gold standard of cancer diagnosis has long been based on histological characteristics. With the rapid advancement of genetic medicine, such standard algorithm of diagnostic approach is facing a challenge. The genetic findings have been changed from being a “supporting character” into the role of a “main character”. More and more disease diagnosis and classification has to be defined by genetic basis. In this article, we focus on the challenges in the field of pediatric oncology. We cited 2 scenarios where genetic information plays a pivotal role in identifying the underlying pathology. The first scenario is that same genetic mutation can lead to variable clinical phenotypes, this includes EWSR1‐PATZ1 fusion related neoplasms; BCOR neoplasms; and GATA‐2 deficiency related immunodeficiency and myelodysplastic syndrome. Another scenario is relatively more common that is the same clinical and histopathological phenotype with different underlying genotypes. The genotypes actually impact on the treatment response and outcome. We used medulloblastoma as an example. In fact, we can also find similar scenario in many pediatric cancers such as Ewing sarcoma, ependymoma, etc. The essence of this article is to remind clinicians of the rapid development in genetic medicine and it has been reshaping the landscape of the modern disease classification and therapeutic approach. In the near future, it may even lead to a paradigm shift in our disease diagnostic algorithm.
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China
Authors: Su Yan , Qin Hong , Chen Chenghao , Wang Shengcai , Zhang Shihan , Zhang Dawei , Jin Mei , Peng Yun , He Lejian , Wang Xiaoman , Qian Suyun , Qin Maoquan , Ge Ming , Zhang Fuquan , Zeng Qi , Wang Huanmin , Ma Xiaoli , Ni Xin 
Published: September 2020

AbstractImportanceNeuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.ObjectiveTo systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.MethodsThis retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed‐up in the Hematology‐Oncology Center of Beijing Children’s Hospital from 2007 to 2019.ResultsThe median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low‐risk, 249 patients (23.9%) were classified as intermediate‐risk, and 549 (52.7%) were classified as high‐risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high‐risk neuroblastoma received hematopoietic stem cell transplantation. The 5‐year event‐free survival (EFS) rate was 91.3% and 5‐year overall survival (OS) rate was 97.5% in low‐risk group; in the intermediate‐risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high‐risk group (P < 0.001 for both). The 5‐year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy‐related complications.InterpretationThe 5‐year OS rate was low in high‐risk patients, compared with low‐and intermediate‐risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high‐risk neuroblastoma.
Dosimetric comparison of tomotherapy and volumetric‐modulated arc therapy for children with neuroblastoma
Authors: Liu Xia , Liu Zhikai , Pang Tingtian , Dong Tingting , Qiu Jie 
Published: September 2020

AbstractImportanceIrradiation treatment for pediatric patients with neuroblastoma represents a major challenge due to the pediatric dose limits for critical structures and the necessity of sufficient dose coverage of the clinical target volume for local control.ObjectiveTo investigate dosimetric differences between tomotherapy (TOMO) and volumetric‐modulated arc therapy (VMAT) as retroperitoneal radiotherapy for children with neuroblastoma.MethodsEight patients who received retroperitoneal radiotherapy for neuroblastoma were selected for comparison of TOMO and VMAT treatment plans. The Dmin, Dmax, Dmean, D95, D2, and D98 of planning target volume (PTV), conformity index (CI), heterogeneity index (HI), and organs at risk (OARs) parameters were compared. Delivery machine unit (MU) and image‐guide radiotherapy solution results were also compared.ResultsAll patients received a cumulative dose of 19.5 Gy to the PTV. VMAT showed higher CI (0.93 ± 0.02), compared with TOMO (0.87 ± 0.03, P < 0.001). Notably, the average PTV HI was significantly better using TOMO (1.05 ± 0.01) than VMAT (1.08 ± 0.02, P = 0.003). Compared with VMAT, the Dmin, D95, and D98 all exhibited increases in TOMO; Dmax variation was less than 1% in TOMO. The D0.1cc for the spinal cord and D2cc for the small intestine were better in TOMO in terms of OARs. However, TOMO had more MUs and required a longer delivery time.InterpretationBoth planning techniques are capable of producing high‐ quality treatment plans. TOMO is superior for PTV coverage, but inferior for CI. TOMO requires extra treatment time; its cost is greater than the cost of VMAT.
Clinical features and predictors of remission in children under the age of 7 years with Graves’ disease
Authors: Gu Yi , Liang Xuejun , Liu Ming , Wu Di , Li Wenjing , Cao Bingyan , Li Yuchuan , Su Chang , Chen Jiajia , Gong Chunxiu 
Published: September 2020

AbstractImportanceGraves’ disease (GD) is rare in children under the age of 7 years. Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy, compared with pubertal and postpubertal children and adults.ObjectiveTo investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.MethodsThis retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology, Beijing Children’s Hospital from 2010 to 2018. Clinical manifestations, laboratory data, and follow‐up records were collected for all patients. Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission; multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.ResultsSixty‐three boys and 14 girls were included; the median age at diagnosis was 4.2 years (interquartile range: 3.2–5.3 years). Forty‐six (56.7%) patients had no family history of thyroid disease, 17 patients had family history of thyroid disease and 14 patients with unknown family history. Of the 77 patients, 18 (23.4%) patients achieved remission of treatment with methimazole and 59 patients did not; moreover, 51 (66.2%) had Graves’ ophthalmopathy. Univariate analyses revealed no significant differences between the remission group and non‐remission group in terms of age at diagnosis, sex, initial goiter size, or initial thyroid hormone concentration. However, there were a trend of correlation between the initial level of thyroid peroxidase antibody (TPOAb) and remission status (univariate analysis OR 1.002, P = 0.038; multivariate analysis OR 1.004, P = 0.019). Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody (TRAb) level, but this association was not significant in multivariate analysis. Cox regression analyses revealed that children with high TRAb level required longer duration of remission, compared with low TRAb level (OR 0.950, 95% CI 0.904–0.997, P = 0.037).InterpretationInitial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD. Initial TRAb level may predict the likelihood of remission in patients with young‐age‐of‐onset GD.
Fabrication of foamed polypropylene with excellent behaviors by adding a special foam stabilizer
Authors: Guo Junyi , Zhang Chen , Liang Shengke , Zou Wei 
Published: September 2020

AbstractFoamed polypropylene (PP) has attracted more and more attention in recent years due to its unique properties, such as heat resistance and high flexural modulus. In this work, foamed PP with excellent properties was successfully fabricated by adding a special foam stabilizer, which was prepared by a simple one‐step strategy using fatty acid and amino silicone oil as reactants. The two‐component stabilizer mixed uniformly with PP and reduced the surface tension during foaming. The foam stabilizer significantly reduced density and cell diameter of the foam. When the amount of foam stabilizer was 1.0 wt%, the density dropped to 0.958 g/cm3, about 2.8% lower vs foam generated without stabilizer. The tensile strength increased to 18.4 MPa from 16.1 MPa, and the elongation at break increased to 495% from 328%.
A comparison of the collagen triple helix and coiled‐coil peptide building blocks on metal ion‐mediated supramolecular assembly
Authors: Curtis Ryan W. , Chmielewski Jean 
Published: September 2020

AbstractMetal ion‐mediated assembly of peptides is an intriguing method for developing novel biomaterials. In particular, peptide building blocks based on collagen triple helical and coiled‐coil peptides have been functionalized with metal‐binding ligands and assemble into hierarchical structures with diverse potential applications. This review outlines the use of metal‐mediated assembly with these supramolecular structures and highlights how changes in the building blocks lead to significant differences in structural morphologies, with the identity of the metal‐binding ligands and their placement on the building block as crucial aspects in the bottom‐up development of the assemblies.
A new class of poly(ether‐block‐amide)s based on semi‐aromatic polyamide: synthesis, characterization and structure–property relations
Authors: Tong Xin , Peng Wei‐Ming , Zhang Mei‐Ling , Wang Xiao‐Jun , Zhang Gang , Long Sheng‐Ru , Yang Jie 
Published: September 2020

AbstractA new type of poly(ether‐amide) thermoplastic elastomer (TPAE) was synthesized using poly(decamethylene terephthalamide (10T)/decamethylene isophthalamide) as hard segment and poly(ethylene glycol) as soft segment via an efficient, accessible and low‐pollution melt polymerization method. Thermoplastic elastomer was synthesized based on semi‐aromatic polyamide for the first time. The effects of various compositions of hard segments on the thermal and mechanical properties were investigated. The results show that TPAE synthesized from semi‐aromatic polyamide has excellent thermal stability, the initial decomposition temperature of all samples being between 370 and 378 °C. With an increase of 10T content, crystallization ability of the hard segment increased. As 10T content increased, TPAE changed from amorphous to crystalline, and the melting temperature ranged from 175 to 236 °C. Tensile testing revealed that TPAE had excellent and adjustable mechanical properties, and that tensile strength, elongation at break and elasticity modulus were in the ranges 7–40 MPa, 468–835% and 0.036–1.80 MPa. Furthermore, high‐temperature tensile test results showed that TPAE‐4 still maintained considerable mechanical properties, and had better mechanical properties compared with Pebax® 5533. In particular, TPAE‐4 had higher performance decay point for which elasticity modulus and stress at ε = 500% decreased rapidly when the temperature was higher than 80 °C, this point for Pebax® 5533 appearing at 50 °C. Such outstanding performance indicated that this new class of elastomer has the potential to be used in high‐temperature conditions. © 2020 Society of Industrial Chemistry
Registration of ‘Curiosity CL+’ soft white winter wheat
Authors: Gill K. S. , Kumar N. , Randhawa H. S. , Carter A. H. , Yenish J. , Morris C. F. , Baik B.‐K. , Higginbotham R. W. , Guy S. O. , Engle D. A. , Chen X. M. , Murray T. D. , Lyon D. J. 
Published: September 2020

Abstract‘Curiosity CL+’ (Reg. no. CV‐1167, PI 675007; PVP 201500290) is a soft white winter (SWW) wheat (Triticum aestivum L.) cultivar carrying two‐gene tolerance to imazamox herbicide that was developed and released by the Agricultural Research Center of Washington State University in October 2013. It was tested under the experimental designations EBC2F3‐3‐18 and WA008143. Curiosity CL+ was developed using marker‐assisted background selection involving a cross between ‘Eltan’ and ‘CL0618’. Eltan was a predominant SWW wheat cultivar (released in 1990) in the Pacific Northwest (PNW), whereas CL0618 is an Australian hard red spring line carrying two‐gene mutations conferring herbicide tolerance. Curiosity CL+ carries two mutation alleles (AhasL‐B1 and AhasL‐D1) of acetolactate synthase gene copies on chromosomes 6B and 6D. Curiosity CL+ has high grain‐yield potential, intermediate plant height, and is well adapted to the dryland production areas of the PNW with <300 mm of annual precipitation. Tested in multiple location and years, Curiosity CL+ showed herbicide tolerance equivalent to the two‐gene Clearfield cultivar ‘AP503 CL2’ (PVP 200800322) and higher than the single‐gene Clearfield cultivar ‘ORCF‐102’ (PI 641787). Its end‐use quality is similar to ORCF‐102, ‘Stephens’ (CI 17596), and ‘Xerpha’ (PI 645605). Compared with Eltan, Curiosity CL+ has better stripe rust resistance, whereas the level of snow mold and Cephalosporium stripe tolerance is equal.
Study on the compatibility of modified cyanate ester resin in liquid oxygen
Authors: Fu Gang , Jiao Weicheng , Wang Guan , Gao Tanling , Wu Jianwei , Shao Nan , Wei Yun Zhao , Kuang Hong , He Xiaodong , Wang Rongguo 
Published: September 2020

AbstractA cyanate ester (CE) resin co‐modified with epoxy (EP) and bismaleimide (BMI) as the continuous phase, and phenolphthalein poly (ether sulfone) (PES‐C) as the dispersed phase were used for developing liquid oxygen (LOX) composite tanks. Gaseous oxygen (GOX) anti‐oxidation, LOX impact sensitivity, ductility, and cycle durability is a critical index for materials in LOX applications. Added components significantly improved material ductility at low temperature versus neat CE resin because of microstructure changes. However, improvement in thermal resistance was not achieved without tradeoffs; the addition of BMI improved thermal resistance but decreased durability. The failure mechanism of a tank containing GOX was related to reaction with oxygen. LOX impact sensitivity (IRS) is associated with anti‐oxidation and flaming retardance of the samples. Micro‐domains tended to separate from the continuous phase more during the LOX impact test versus the GOX test and was accompanied by increasing ductility and anti‐oxidation. Cycle durability was affected more by the difference in coefficient of thermal expansion between the continuous and PES‐C phases rather than immersion time. In summary, CE resin (CYEP6BM5) co‐modified with PES‐C, EP, and BMI showed good LOX compatibility including IRS value of 2%, 19 cycles durability, and flaming retardance of UL94V0 and may be applied for LOX composite tanks.
Local Anesthesia Prior to Ultrasound‐Guided Hip Joint Injections: A Double‐Blind Randomized Controlled Trial of Bacteriostatic Saline versus Buffered Lidocaine
Authors: Kruse Ryan C. , Kindle Brett J. , Wisniewski Steve , Presley James , Smith Jay , Sellon Jacob L. 
Published: September 2020

BackgroundUltrasound (US)‐guided hip joint injections are commonly performed for patients with suspected or known intra‐articular hip pain. Lidocaine is a well‐established local anesthetic used prior to hip joint injections, but it is often associated with discomfort during infiltration. Bacteriostatic saline is an alternative local anesthetic that has been shown to be less painful during infiltration for superficial injections.ObjectiveTo compare infiltrative pain and anesthetic efficacy of bacteriostatic saline (0.9% benzyl alcohol) with a standard local anesthetic (buffered 1% lidocaine) used for local anesthesia prior to US‐guided intra‐articular hip corticosteroid injections.DesignDouble‐blinded, randomized controlled trial.SettingTertiary care medical center.ParticipantsSixty eight patients age 18‐80 (mean 54.8) years referred for US‐guided intra‐articular hip corticosteroid injections.InterventionPatients were randomized to receive a US‐guided hip joint corticosteroid injection using either bacteriostatic saline or buffered 1% lidocaine for preinjection local anesthesia.Main Outcome MeasuresVisual Analog Scale (VAS) for pain (0‐100) during local anesthetic infiltration as well as during the intra‐articular injection. Adverse events were also recorded.ResultsThere were no significant differences between bacteriostatic saline and buffered lidocaine with respect to pain during local anesthetic infiltration or during the subsequent intra‐articular injection. Pain VAS during local anesthetic infiltration was 13.2 (95% confidence interval [CI] 7.8, 18.5) in the bacteriostatic saline group and 14.0 (95% CI 9.4, 18.5) in the buffered 1% lidocaine group (P = .82). Furthermore, pain VAS during the intra‐articular injection was 20.7 (95% CI 14.1, 27.3) in the bacteriostatic saline group and 15.7 (95% CI 10.9, 20.3) in the buffered 1% lidocaine group (P = .57). No adverse events occurred.ConclusionsBacteriostatic saline is a safe and comparably effective alternative to buffered 1% lidocaine for local anesthesia before US‐guided hip joint injections and may be considered for subcutaneous/periarticular anesthesia during similar musculoskeletal procedures.
Predicting novel strong acids of plumbylene at theoretical levels
Authors: Mohebi Nazanin , Kassaee Mohamad Z. 
Published: September 2020

AbstractWe have reached at new acyclic plumbylenes which show high acidity, via B3LYP, Def2‐TZVP, MP2, and wB97XD functionals. Our scrutinized plumbylenes include dicyclopropaplumbylene (1), dicyclopentaplumbylene (2), dicycloheptaplumbylene (3), and their unsaturated analogs (1’‐3’, respectively). All scrutinized plumbylenes and their corresponding protonated forms, 1H(1’H)‐3H(3’H), appear as minima on their energy surfaces. The conductor‐like polarizable continuum model (CPCM) and integral equation formalism polarized continuum model (IEFPCM) are used to predict the pka values for electrophilic plumbylenes, 1(1’)‐3(3’), in chloroform and water. In most cases, plumbylenes turn out as strong acids for showing relatively high negative pka values. The acidity trend of plumbylenes (pka) appears consistent with their proton affinity (PA), electrophilicity (ω), nucleophilicity (N), Mulliken electronegativity (
), absolute chemical hardness (ηabs), singlet‐triplet energy gap (ΔEs‐t), and highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) energy gap (ΔEH‐L). Structure 1, with two cyclopropyl groups, turns out as the most acidic specie in chloroform and water.
Plasma‐based VAD process for multiply doped glass powders and high‐performance fiber preforms with outstanding homogeneity
Authors: Trautvetter Tom , Schäfer Jan , Benzine Omar , Methling Ralf , Baierl Hardy , Reichel Volker , Dellith Jan , Köpp Daniel , Hempel Frank , Stankov Marjan , Baeva Margarita , Foest Rüdiger , Wondraczek Lothar , Wondraczek Katrin , Bartelt Hartmut 
Published: September 2020

AbstractAn innovative approach using the vapor axial deposition (VAD), for the preparation of silica‐based high‐power fiber laser preforms, is described in this study. The VAD uses a plasma deposition system operating at atmospheric pressure, fed by a single, chemically adapted solution containing precursors of laser‐active dopants (e.g., Yb2O3), glass‐modifier species (e.g., Al2O3), and the silica matrix. The approach enables simultaneous doping with multiple optically active species and overcomes some of the current technological limitations encountered with well‐established fiber preform technologies in terms of dopant distribution, doping levels, and achievable active core diameter. The deposition of co‐doped silica with outstanding homogeneity is proven by Raman spectroscopy and electron probe microanalysis. Yb2O3 concentrations are realized up to 0.3 mol% in SiO2, with simultaneous doping of 3 mol% of Al2O3.