bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goodbye to Grand Politics: The Cane Sugar Campaign and the Limits of Transnational Activism, 1968–1974
Authors: van Dam Peter 
Published: October 2019

AbstractIn 1968 Dutch activists launched a campaign focused on cane sugar as a symbol of unfair trading conditions for the global South. The history of the cane sugar campaign from 1968 to 1974 highlights how European integration provided hope for large-scale change and a common target. This led activists to establish European networks and campaigns. Its demise sheds new light on the new social movements’ shift from ‘grand politics’, aimed at a sudden and drastic transformation through global and European politics, towards incremental change by locally targeting specific companies and countries.
Consuming Anti-Consumerism: The German Fairtrade Movement and the Ambivalent Legacy of ‘1968’
Authors: Möckel Benjamin 
Published: October 2019

AbstractThe article explores the influence of ‘1968’ on the West German fair trade movement. It argues that 1968 constituted an ambivalent legacy for the perception of mass consumerism: while the 1960s student movement radically criticised modern consumer society, it also put new emphasis on consumer products as markers of individual identity. The article analyses this relationship by focusing on the design, representation and advertising of fair trade products by the German fair trade organation GEPA. The first two case studies examine the politicisation of fair trade products in its early campaigns in the 1970s and the subsequent attempts to use everyday products like coffee, tea and honey to educate consumers about their individual lifestyles. The third case study looks at the GEPA's first mail-order catalogues and asks how the GEPA tried to transform an icon of modern mass consumerism into a tool to communicate its fair trade approach.
In congenitally corrected transposition of great arteries following Fontan surgery, a left ventricle with suprasystemic systolic and high end-diastolic pressures paradoxically preserves right ventricular and tricuspid valve function
Authors: Wadile Santosh , Sheriff Ejaz A. , Sivakumar Kothandam 
Published: October 2019

AbstractSystemic right ventricular function in congenitally corrected transposition depends on septal geometry. Suprasystemic left ventricular systolic pressures and high end-diastolic pressures after Fontan surgery paradoxically preserve right ventricular function.
Language selection contributes to intrusion errors in speaking: Evidence from picture naming
Authors: Zheng Xiaochen , Roelofs Ardi , Lemhöfer Kristin 
Published: October 2019

AbstractBilinguals usually select the right language to speak for the particular context they are in, but sometimes the nontarget language intrudes. Despite a large body of research into language selection and language control, it remains unclear where intrusion errors originate from. These errors may be due to incorrect selection of the nontarget language at the conceptual level, or be a consequence of erroneous word selection (despite correct language selection) at the lexical level. We examined the former possibility in two language switching experiments using a manipulation that supposedly affects language selection on the conceptual level, namely whether the conversational language context was associated with the target language (congruent) or with the alternative language (incongruent) on a trial. Both experiments showed that language intrusion errors occurred more often in incongruent than in congruent contexts, providing converging evidence that language selection during concept preparation is one driving force behind language intrusion.
Are similar control processes implemented during single and dual language production? Evidence from switching between speech registers and languages
Authors: Declerck Mathieu , Ivanova Iva , Grainger Jonathan , Duñabeitia Jon Andoni 
Published: October 2019

AbstractTo investigate whether similar control processes are used during single and dual language production, we compared register switching (formal and informal speech in the same language) vs. language switching (French and English). The results across two experiments showed a positive correlation of overall register- and language-switch costs and similar formal French switch costs across the two switching tasks. However, whereas increasing the cue-to-stimulus interval resulted in a reduction of language-switch costs, register-switch costs were unaffected by the interval manipulation. This difference in switch-cost pattern indicates that control processes are not entirely identical during single and dual language production.
Advancement of taxonomic searches in the European search catalogue for plant genetic resources
Authors: Kreide Stefanie , Oppermann Markus , Weise Stephan 
Published: October 2019

AbstractGenebanks play an important role in the conservation of global plant biodiversity. The European Search Catalogue for Plant Genetic Resources (EURISCO) was created as a central entry point to provide information on these collections. However, a major challenge lies in the heterogeneity of scientific plant names. This makes the selection of suitable plant material, e.g. for research or breeding purposes, significantly more difficult. For this reason, the taxonomic backbone of EURISCO has been completely revised. Search terms entered by users are now automatically checked against taxonomic reference repositories, allowing a variety of synonyms to be identified. In addition, a fuzzy search has been implemented, which makes the search function tolerant of erroneous data (e.g. caused by typing errors). Besides improvements of the search interface, more support will be given to EURISCO's data providers. The new developments provide a tool that makes it easier to identify problem cases within the data, such as accepted/non-accepted taxonomic names, and will successively improve the quality of taxonomic information in EURISCO.
Physicians' attitudes towards accelerated access to medicines
Authors: Pace Jessica , Kerridge Ian , Pearson Sallie , Lipworth Wendy 
Published: October 2019

AbstractIn recent years, a variety of ‘accelerated access’ schemes have been introduced by pharmaceutical regulators and funders globally. These schemes aim to overcome perceived regulatory and reimbursement barriers to accessing medicines – particularly for patients with limited time or therapeutic options. However, patient access to approved medicines is mediated by a number of third parties including regulators and payers, and physicians who act both as gatekeepers and guides to prescribed medications. It is therefore essential to know how physicians think about accelerated access as they are responsible for advising patients on and prescribing medicines made available via these pathways. We conducted semi-structured interviews with 18 Australian physicians focusing on their attitudes towards accelerated access. We identified three ‘archetypes’ of physicians: ‘confident accelerators’, ‘cautious accelerators’, and ‘decelerators’. Although all acknowledged the potential risks and benefits of accelerated access, they disagreed on their magnitude and extent and how they should be balanced in both policy formation and clinical practice. Overall, our results illustrate the diversity of clinical opinions in this area and the importance of monitoring both the prescribing and clinical outcomes that result from accelerated access programmes to ensure that these are both clinically and morally acceptable.
Big Data Enters Environmental Law
Authors: Lajaunie Claire , Schafer Burkhard , Mazzega Pierre 
Published: October 2019

AbstractBig Data is now permeating environmental law and affecting its evolution. Data-driven innovation is highlighted as a means for major organizations to address social and global challenges. We present various contributions of Big Data technologies and show how they transform our knowledge and understanding of domains regulated by environmental law – environmental changes, socio-ecological systems, sustainable development issues – and of environmental law itself as a complex system. In particular, the mining of massive data sets makes it possible to undertake concrete actions dedicated to the elaboration, production, implementation, follow-up, and adaptation of the environmental targets defined at various levels of decision making (from the international to the subnational level).This development calls into question the traditional approach to legal epistemology and ethics, as implementation and enforcement of rules take on new forms, such as regulation through smart environmental targets and securing legal compliance through the design of technological artefacts. The entry of Big Data therefore requires the development of a new and specific epistemology of environmental law.
High‐Speed Solar Wind Streams in 2007–2008: Turning on the Russell‐McPherron Effect
Authors: Munteanu C. , Hamada A. , Mursula K. 
Published: October 2019

AbstractTwo sequences of five high‐speed solar wind stream/corotating interaction region (HSS/CIR) events were observed at 1 AU in December 2007–2008. These two HSS/CIR sequences had opposite magnetic polarities, and they originated from two persistent low‐latitude coronal holes with corresponding polarities. Each HSS/CIR event triggered a geomagnetic storm and strong high‐latitude activity. We follow the evolution of the properties and geomagnetic effects of the two sequences and find that the sequence with negative interplanetary magnetic field polarity (toward sector) develops systematically a more negative Bz(GSM) component and becomes relatively more geoeffective when moving from winter solstice in 2007 to spring equinox in 2008. On the other hand, the sequence with positive polarity (away sector) develops systematically a less negative Bz(GSM) component and becomes relatively less geoeffective. These changes allow the first detailed monitoring of the turning on of the Russell‐McPherron effect when moving from solstice to equinox and the development of the related changes in high‐latitude geomagnetic activity and geomagnetic storms.
Reply to Comment by Jennings et al. on “Investigating Earth's Formation History Through Copper and Sulfur Metal‐Silicate Partitioning During Core‐Mantle Differentiation”
Authors: Mahan B. , Siebert J. , Badro J. , Borensztajn S. , Moynier F. 
Published: October 2019

AbstractRecognizing existing materials that can act as proxies for Earth's building blocks, and understanding the accretionary pathway taken during Earth's growth, persist as outstanding issues in need of resolution. In Mahan, Siebert, Blanchard, Badro, et al. (2018, https://doi.org/10.1029/2018JB015991), we conducted diamond anvil cell (DAC) Cu metal‐silicate partitioning experiments and coupled these results with a large complement of literature data to characterize Cu metal‐silicate partitioning during Earth's core formation and accretion history. The Comment of Jennings, Wade, and Llovet (2019, https://doi.org/10.1029/2018JB016930) contends that secondary X‐ray fluorescence, originating from the Cu holders that experiments are routinely welded to (“lift‐out” grids), compromises the novel Cu partitioning data of Mahan, Siebert, Blanchard, Badro, et al. (2018) beyond utility. To dispel these concerns and further validate our data, we have (i) investigated secondary X‐ray fluorescence effects in a Cu‐free experiment and provided a matrix‐matched data correction, and (ii) rewelded a DAC experiment from a Cu grid to a Mo grid for a comparison of compositional analyses and Cu partitioning results. Secondary fluorescence results, in fact much like the simulated results in Jennings, Wade, and Llovet (2019), indicate that this effect is essentially equal in the metal and silicate phases and therefore has no actual impact on Cu metal‐silicate partition coefficients. Moreover, Cu concentrations and partition coefficients determined using the Mo grid are statistically indistinguishable from that determined using the Cu grid. All results decisively illustrate that while secondary X‐ray fluorescence must be considered where absolute concentrations are the final objective, it has had no meaningful impact on the partitioning data and observations of Mahan, Siebert, Blanchard, Badro, et al. (2018).
Systematic Detection of Clustered Seismicity Beneath the Southwestern Alps
Authors: Beaucé Eric , Frank William B. , Paul Anne , Campillo Michel , van der Hilst Robert D. 
Published: October 2019

AbstractWe present a new automated earthquake detection and location method based on beamforming (or back projection) and template matching and apply it to study the seismicity of the Southwestern Alps. We use beamforming with prior knowledge of the 3‐D variations of seismic velocities as a first detection run to search for earthquakes that are used as templates in a subsequent matched‐filter search. Template matching allows us to detect low signal‐to‐noise ratio events and thus to obtain a high spatiotemporal resolution of the seismicity in the Southwestern Alps. We describe how we address the problem of false positives in energy‐based earthquake detection with supervised machine learning and how to best leverage template matching to iteratively refine the templates and the detection. We detected 18,754 earthquakes over 1 year (our catalog is available online) and observed temporal clustering of the earthquake occurrence in several regions. This statistical study of the collective behavior of earthquakes provides insights into the mechanisms of earthquake occurrence. Based on our observations, we infer the mechanisms responsible for the seismic activity in three regions of interest: the Ubaye valley, the Briançonnais, and the Dora Maira massif. Our conclusions point to the importance of fault interactions to explain the earthquake occurrence in the Briançonnais and the Dora Maira massif, whereas fluids seem to be the major driving mechanism in the Ubaye valley.
Inverse Magnetic Susceptibility Fabrics in Pelagic Sediment: Implications for Magnetofossil Abundance and Alignment
Authors: Usui Yoichi , Yamazaki Toshitsugu , Oka Toshitaka , Kumagai Yuho 
Published: October 2019

AbstractSingle‐domain magnetite particles exhibit minimum susceptibility along their elongation, resulting in so‐called inverse fabric of the anisotropy of magnetic susceptibility (AMS). We report the discovery of inverse AMS fabrics from pelagic clay recovered by a ∼12 m long piston core from the western North Pacific. A previous study identified fossil single‐domain magnetite produced by magnetotactic bacteria (magnetofossils) as the dominant ferrimagnetic mineral in the sediment. The inverse AMS fabrics were found in a ∼2 m zone. The ∼6 and ∼4 m of sediment above and below this zone showed normal, horizontal AMS fabrics. Rock magnetic data and ferromagnetic resonance spectroscopy indicated that magnetofossils account for most of the mean susceptibility regardless of normal or inverse AMS. This was explained by the mixing models where the inverse fabric from magnetofossils is nearly balanced by the normal fabrics of terrigenous minerals. The corrected degree of AMS carried by magnetofossils in the sediment was estimated to be ∼1.01, which is comparable to that of typical pelagic sediment at shallow depth. On the other hand, terrigenous minerals in the sediment were estimated to have higher degree of anisotropy, possibly reflecting burial and subsequent erosion of >80 m of sediment, which was also suggested by a subbottom acoustic stratigraphy. This suggests that inverse AMS fabrics due to magnetofossils may be widespread in pelagic clay without strong compaction.
The Nearshore Heat Budget: Effects of Stratification and Surfzone Dynamics
Authors: Sinnett Gregory , Feddersen Falk 
Published: October 2019

AbstractTemperature variability in the nearshore (from ≈6‐m depth to the shoreline) is influenced by many processes including wave breaking and internal waves. A nearshore heat budget resolving these processes has not been considered. A 7‐month experiment at the Scripps Institution of Oceanography Pier (shoreline to 6‐m depth) measured temperature and surface and cross‐shore heat fluxes to examine a nearshore heat budget with fine cross‐shore spatial (≈20 m) and temporal (5 day to 4 h) resolution. Winds, waves, air and water temperature, and in particular, pier end stratification varied considerably from late Fall to late Spring. The largest heat flux terms were shortwave solar radiation and baroclinic advective heat flux both varying on tidal time scales. The net heat flux is coherent and in phase with the nearshore heat content change at diurnal and semidiurnal frequencies. The binned mean heat budget has squared correlation R2=0.97 and best‐fit slope of 0.76. Including an elevated breaking wave albedo parameterization reduced the residual heat flux and improved the best‐fit slope. Baroclinic and barotropic advective heat fluxes have significant noise, and removing them from the heat budget improves the best‐fit slope when stratification is weak. However, when daily mean stratification is large, baroclinic advective heat flux dominates variability and is required to capture large (≈3 °C h−1) internal wave events. At times, large heat budget residuals highlight neglected heat budget terms, pointing to surfzone alongshore advection of temperature anomalies.
Structure and Performance of GFDL's CM4.0 Climate Model
Authors: Held I. M. , Guo H. , Adcroft A. , Dunne J. P. , Horowitz L. W. , Krasting J. , Shevliakova E. , Winton M. , Zhao M. , Bushuk M. , Wittenberg A. T. , Wyman B. , Xiang B. , Zhang R. , Anderson W. , Balaji V. , Donner L. , Dunne K. , Durachta J. , Gauthier P. P. G. , Ginoux P. , Golaz J.‐C. , Griffies S. M. , Hallberg R. , Harris L. , Harrison M. , Hurlin W. , John J. , Lin P. , Lin S.‐J. , Malyshev S. , Menzel R. , Milly P. C. D. , Ming Y. , Naik V. , Paynter D. , Paulot F. , Ramaswamy V. , Reichl B. , Robinson T. , Rosati A. , Seman C. , Silvers L. G. , Underwood S. , Zadeh N. 
Published: October 2019

AbstractWe describe the Geophysical Fluid Dynamics Laboratory's CM4.0 physical climate model, with emphasis on those aspects that may be of particular importance to users of this model and its simulations. The model is built with the AM4.0/LM4.0 atmosphere/land model and OM4.0 ocean model. Topics include the rationale for key choices made in the model formulation, the stability as well as drift of the preindustrial control simulation, and comparison of key aspects of the historical simulations with observations from recent decades. Notable achievements include the relatively small biases in seasonal spatial patterns of top‐of‐atmosphere fluxes, surface temperature, and precipitation; reduced double Intertropical Convergence Zone bias; dramatically improved representation of ocean boundary currents; a high‐quality simulation of climatological Arctic sea ice extent and its recent decline; and excellent simulation of the El Niño‐Southern Oscillation spectrum and structure. Areas of concern include inadequate deep convection in the Nordic Seas; an inaccurate Antarctic sea ice simulation; precipitation and wind composites still affected by the equatorial cold tongue bias; muted variability in the Atlantic Meridional Overturning Circulation; strong 100 year quasiperiodicity in Southern Ocean ventilation; and a lack of historical warming before 1990 and too rapid warming thereafter due to high climate sensitivity and strong aerosol forcing, in contrast to the observational record. Overall, CM4.0 scores very well in its fidelity against observations compared to the Coupled Model Intercomparison Project Phase 5 generation in terms of both mean state and modes of variability and should prove a valuable new addition for analysis across a broad array of applications.
Circulating biomarkers in patients with glioblastoma
Authors: Müller Bark Juliana , Kulasinghe Arutha , Chua Benjamin , Day Bryan W. , Punyadeera Chamindie 
Published: October 2019

AbstractGliomas are the most common tumours of the central nervous system and the most aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival remains low. GBM diagnosis typically relies on imaging techniques and postoperative pathological diagnosis; however, both procedures have their inherent limitations. Imaging modalities cannot differentiate tumour progression from treatment-related changes that mimic progression, known as pseudoprogression, which might lead to misinterpretation of therapy response and delay clinical interventions. In addition to imaging limitations, tissue biopsies are invasive and most of the time cannot be performed over the course of treatment to evaluate ‘real-time’ tumour dynamics. In an attempt to address these limitations, liquid biopsies have been proposed in the field. Blood sampling is a minimally invasive procedure for a patient to endure and could provide tumoural information to guide therapy. Tumours shed tumoural content, such as circulating tumour cells, cell-free nucleic acids, proteins and extracellular vesicles, into the circulation, and these biomarkers are reported to cross the blood–brain barrier. The use of liquid biopsies is emerging in the field of GBM. In this review, we aim to summarise the current literature on circulating biomarkers, namely circulating tumour cells, circulating tumour DNA and extracellular vesicles as potential non-invasively sampled biomarkers to manage the treatment of patients with GBM.
Salt-inducible kinase 1 regulates bone anabolism via the CRTC1–CREB–Id1 axis
Authors: Kim Min Kyung , Kwon Jun-Oh , Song Min-Kyoung , Kim Bongjun , Kim Haemin , Lee Zang Hee , Koo Seung-Hoi , Kim Hong-Hee 
Published: October 2019

AbstractNew bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary preosteoblasts increased osteoblast differentiation and bone matrix mineralization. SIK1 also regulated the proliferation of osteoblastic precursor cells in osteogenesis. This negative control of osteoblasts required the catalytic activity of SIK1. SIK1 phosphorylated CREB regulated transcription coactivator 1 (CRTC1), preventing CRTC1 from enhancing CREB transcriptional activity for the expression of osteogenic genes like Id1. Furthermore, SIK1 knockout (KO) mice had higher bone mass, osteoblast number, and bone formation rate versus littermate wild-type (WT) mice. Preosteoblasts from SIK1 KO mice showed more osteoblastogenic potential than did WT cells, whereas osteoclast generation among KO and WT precursors was indifferent. In addition, bone morphogenic protein 2 (BMP2) suppressed both SIK1 expression as well as SIK1 activity by protein kinase A (PKA)–dependent mechanisms to stimulate osteogenesis. Taken together, our results indicate that SIK1 is a key negative regulator of preosteoblast proliferation and osteoblast differentiation and that the repression of SIK1 is crucial for BMP2 signaling for osteogenesis. Therefore, we propose SIK1 to be a useful therapeutic target for the development of bone anabolic strategies.