bluuebunny/crossref_metadata_2025_split huggingface dataset:
OMS: Opportunistic mules for short latency data collection in smart cities
Authors: Chehbour Fairouz , Doukha Zouina , Moussaoui Samira , Guerroumi Mohamed 
Published: November 2019

SummaryIn smart city scenarios, data collected by sensors are required to be conveyed to central controllers for processing. Thus, efficient data collection mechanisms considering the urban environment characteristics should take place. To that end, the data mules approach is proved to be efficient. However, being applied to urban environment leads to high data delivery latency due to the characteristics of this environment. Motivated by the need to reduce the collection latency of such an approach, we propose to provide each road segment with a data mule to create a process of distributed data collection. Our scheme leverages opportunistic inter‐vehicular communications for assigning the mule role to adequate vehicles. The simulation in realistic mobility settings reveals that our scheme can provide more than 80% of the area of interest with data mules in less than 1 minute. In addition, the data collection latency can be reduced from 24 hours to few minutes.
A microfacies analysis of arid continental carbonates from the Cedar Mesa Sandstone Formation, Utah, USA
Authors: Pettigrew Ross P. , Rogers Steven L. , Clarke Stuart M. 
Published: November 2019

AbstractArid continental environments are typically dominated by siliciclastic aeolian, alluvial and fluvial deposits. Despite their common recognition within these environments, carbonate deposits are often overlooked, yet they can provide vital insight into the depositional history, climate and tectonic controls of a sedimentary basin. This work presents a detailed microfacies analysis of the carbonates found within the Cedar Mesa Sandstone Formation of the Western USA. The Cedar Mesa Sandstone Formation is an early Permian, predominantly aeolian succession, exposed across much of the Colorado Plateau of southern Utah and northern Arizona. The formation is dominantly clastic erg deposits, that grade into a mixed carbonate/clastic sedimentary succession interbedded with carbonate and evaporitic units, interpreted to represent sabkha or sabkha‐like deposits. While many authors have worked within the aeolian dominated facies and have proposed various facies schemes for the siliciclastic components, comparatively little attention has been paid to the mixed evaporitic/clastic/carbonate aeolian‐sabkha transition zone. In this work the microfacies of the carbonates present within the Cedar Mesa Sandstone are analysed, in order to: (a) develop a record of, and interpret carbonate components, (b) propose depositional mechanisms and (c) identify evolutionary trends that stand alongside the formation's clastic depositional story. Six microfacies are presented: (MF1) Clastic Influenced Carbonate Wackestone; (MF2) Laminated Carbonate Wackestone/Packstone; (MF3) Microbial Laminated Fenestral Bindstone; (MF4) Rounded Mudclast Wackestone; (MF5) Laminated Bioclastic‐Ostracod‐Carbonate Wackestone and (MF6) Microcrystalline Quartz. The microfacies have been interpreted to document the development of carbonate interdune, lacustrine and continental sabkha environments influenced by localized fault control juxtaposed across a wetting and drying climate cycle and provide useful comparisons for other mixed evaporite/carbonate and clastic sequences.
Circadian‐timed quick‐release bromocriptine lowers elevated resting heart rate in patients with type 2 diabetes mellitus
Authors: Chamarthi Bindu , Vinik Aaron , Ezrokhi Michael , Cincotta Anthony H. 
Published: November 2019

AbstractObjectiveSympathetic nervous system (SNS) overactivity is a risk factor for insulin resistance and cardiovascular disease (CVD). We evaluated the impact of bromocriptine‐QR, a dopamine‐agonist antidiabetes medication, on elevated resting heart rate (RHR) (a marker of SNS overactivity in metabolic syndrome), blood pressure (BP) and the relationship between bromocriptine‐QR's effects on RHR and HbA1c in type 2 diabetes subjects.Design and SubjectsRHR and BP changes were evaluated in this post hoc analysis of data from a randomized controlled trial in 1014 type 2 diabetes subjects randomized to bromocriptine‐QR vs placebo added to standard therapy (diet ± ≤2 oral antidiabetes medications) for 24 weeks without concomitant antihypertensive or antidiabetes medication changes, stratified by baseline RHR (bRHR).ResultsIn subjects with bRHR ≥70 beats/min, bromocriptine‐QR vs placebo reduced RHR by −3.4 beats/min and reduced BP (baseline 130/79; systolic, diastolic, mean arterial BP reductions [mm Hg]: −3.6 [P = .02], −1.9 [P = .05], −2.5 [P = .02]). RHR reductions increased with higher baseline HbA1c (bHbA1c) (−2.7 [P = .03], −5 [P = .002], −6.1 [P = .002] with bHbA1c ≤7, >7, ≥7.5%, respectively] in the bRHR ≥70 group and more so with bRHR ≥80 (−4.5 [P = .07], −7.8 [P = .015], −9.9 [P = .005]). Subjects with bRHR <70 had no significant change in RHR or BP. With bHbA1c ≥7.5%, %HbA1c reductions with bromocriptine‐QR vs placebo were −0.50 (P = .04), −0.73 (P = .005) and −1.22 (P = .008) with bRHR <70, ≥70 and ≥80, respectively. With bRHR ≥70, the magnitude of bromocriptine‐QR‐induced RHR reduction was an independent predictor of bromocriptine‐QR's HbA1c lowering effect.ConclusionBromocriptine‐QR lowers elevated RHR with concurrent decrease in BP and hyperglycaemia. These findings suggest a potential sympatholytic mechanism contributing to bromocriptine‐QR's antidiabetes effect and potentially its previously demonstrated effect to reduce CVD events.
Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: a meta‐analysis
Authors: Michel Lars , Mincu Raluca I. , Mahabadi Amir A. , Settelmeier Stephan , Al‐Rashid Fadi , Rassaf Tienush , Totzeck Matthias 
Published: November 2019

AbstractAimsCardiac biomarkers are a mainstay in diagnosis of cardiovascular disease but their role in cardio‐oncology has not yet been systematically evaluated. This meta‐analysis aims to determine whether cardiac troponins and (N‐terminal pro) brain natriuretic peptide (BNP/NT‐proBNP) predict cancer therapy‐related left ventricular (LV) dysfunction.Methods and resultsScientific databases were searched for studies that assessed troponins or BNP/NT‐proBNP in adult patients undergoing cancer therapy. Data from 61 trials with 5691 patients were included. Cancer therapy was associated with an increase in troponin levels [odds ratio (OR) 14.3, 95% confidence interval (CI) 6.0–34.1; n = 3049]. Patients with elevated troponins receiving chemotherapy or human epidermal growth factor receptor 2 inhibitor therapy were at higher risk for LV dysfunction (OR 11.9, 95% CI 4.4–32.1; n = 2163). Troponin had a negative predictive value of 93%. Mean BNP/NT‐proBNP levels were increased in patients post‐treatment (standardized mean difference 0.6, 95% CI 0.3–0.9; n = 912), but the available evidence did not consistently indicate prediction of LV dysfunction (OR 1.7, 95% CI 0.7–4.2; n = 197). β‐blocker and angiotensin‐converting enzyme inhibitor therapy to mitigate cardiotoxicity during cancer therapy was associated with a decline in serum troponins (OR 4.1, 95% CI 1.7–9.8; n = 466).ConclusionElevated troponin levels predict LV dysfunction in patients receiving cancer therapy. Assessment of troponin levels may qualify as a screening test to identify patients who require referral to cardio‐oncology units and benefit from preventive strategies. Further evidence is required for both biomarkers.
Anti‐TNF treatment negatively regulates human CD4+ T‐cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype
Authors: Povoleri Giovanni A. M. , Lalnunhlimi Sylvine , Steel Kathryn J. A. , Agrawal Shweta , O'Byrne Aoife M. , Ridley Michael , Kordasti Shahram , Frederiksen Klaus S. , Roberts Ceri A. , Taams Leonie S. 
Published: November 2019

AbstractTNF‐blockade has shown clear therapeutic value in rheumatoid arthritis and other immune‐mediated inflammatory diseases, however its mechanism of action is not fully elucidated. We investigated the effects of TNF‐blockade on CD4+ T cell activation, maturation, and proliferation, and assessed whether TNF‐inhibitors confer regulatory potential to CD4+ T cells. CyTOF and flow cytometry analysis revealed that in vitro treatment of human CD4+ T cells with the anti‐TNF monoclonal antibody adalimumab promoted IL‐10 expression in CD4+ T cells, whilst decreasing cellular activation. In line with this, analysis of gene expression profiling datasets of anti‐TNF‐treated IL‐17 or IFN‐γ‐producing CD4+ T cells revealed changes in multiple pathways associated with cell cycle and proliferation. Kinetics experiments showed that anti‐TNF treatment led to delayed, rather than impaired T‐cell activation and maturation. Whilst anti‐TNF‐treated CD4+ T cells displayed some hyporesponsiveness upon restimulation, they did not acquire enhanced capacity to suppress T‐cell responses or modulate monocyte phenotype. These cells however displayed a reduced ability to induce IL‐6 and IL‐8 production by synovial fibroblasts. Together, these data indicate that anti‐TNF treatment delays human CD4+ T‐cell activation, maturation, and proliferation, and this reduced activation state may impair their ability to activate stromal cells.
Amine‐Functionalized Spin Crossover Building Blocks
Authors: Flötotto Henrik , Secker Tim , Kögerler Paul , Besson Claire 
Published: November 2019

AbstractInvited for the cover of this issue is the group of Paul Kögerler from RWTH Aachen University, Germany. The cover image shows an aluminum sheet painted with thermochromic lacquer based on functionalized derivatives of iron(II) bis(tris(pyrazolyl)borate) complexes.
The Flavor Enhancer Maltol Increases Pigment Aggregation in Dermal and Neural Melanophores in Xenopus laevis Tadpoles
Authors: Dahora Lara I. , Fitzgerald Ashley , Emanuel Matthew , Baiges Alexa F. , Husain Zahabiya , Thompson Christopher K. 
Published: November 2019

Abstract
Melanophores are pigmented cells that change the distribution of melanosomes, enabling animals to appear lighter or darker for camouflage, thermoregulation, and protection from ultraviolet radiation. A complex series of hormonal and neural mechanisms regulates melanophore pigment distribution, making these dynamic cells a valuable tool to screen toxicants as they rapidly respond to changes in the environment. We found that maltol, a naturally occurring flavor enhancer and fragrance agent, induces melanophore pigment aggregation in a dose-dependent manner in Xenopus laevis tadpoles. To determine if maltol affects camouflage adaptation, we placed tadpoles into maltol baths situated over either a white or a black background. Maltol induced pigment aggregation in a similar dose-dependent pattern regardless of background color. We also tested how maltol treatment compares to melatonin treatment and found that the degree of pigment aggregation induced by maltol is similar to treatment with melatonin but that maltol induces over a much longer time course. Last, maltol had no effect on mRNA expression in the brain of genes that regulate camouflage-related pigment aggregation. The present results suggest that maltol does not exert its effects via the camouflage adaptation mechanism or via melatonin-related mechanisms. These results are the first to identify a putative toxicological effect of maltol exposure in vivo and rule out several mechanisms by which maltol may exert its effects on pigment aggregation. Environ Toxicol Chem 2020;39:381–395. © 2019 SETAC
Primates got personality, too: Toward an integrative primatology of consistent individual differences in behavior
Authors: Blaszczyk Maryjka B. 
Published: November 2019

AbstractIn recent years, research on animal personality has exploded within the field of behavioral ecology. Consistent individual differences in behavior exist in a wide range of species, and these differences can have fitness consequences and influence several aspects of a species' ecology. In comparison to studies of other animals, however, there has been relatively little research on the behavioral ecology of primate personality. This is surprising given the large body of research within psychology and biomedicine showing that primate personality traits are heritable and linked to health and life history outcomes. In this article, I bring together theoretical perspectives on the ecology and evolution of animal personality with an integrative review of what we know about primate personality from studies conducted on captive, free‐ranging, and wild primates. Incorporating frameworks that emphasize consistency in behavior into primate behavioral ecology research holds promise for improving our understanding of primate behavioral evolution.
Domain decomposition methods in a geometrical multiscale domain using finite volume schemes
Authors: Viallon Marie‐Claude 
Published: November 2019

SummaryThe heat equation is solved by using a finite volume discretization in a domain that consists of a two‐dimensional central node and several one‐dimensional outgoing branches. Several interface connection options to match the submodels set on the node and on the branches, with or without continuity, are looked at. For each of them, a monolithic scheme is defined, and existence and uniqueness of the solution is proved. New schemes are deduced, which are obtained through domain decomposition methods in the form of interface systems, with one or two unknowns per interface. A comparative systematic study is carried out from an algebraic and numerical point of view according to the interface conditions: Dirichlet, Neumann, or Robin. An efficient diagonal preconditioning is proposed.
A high‐order compact scheme for solving the 2D steady incompressible Navier‐Stokes equations in general curvilinear coordinates
Authors: Chen Jinqiang , Yu Peixiang , Tian Zhen F. , Ouyang Hua 
Published: November 2019

SummaryIn this paper, a high‐order compact finite difference algorithm is established for the stream function‐velocity formulation of the two‐dimensional steady incompressible Navier‐Stokes equations in general curvilinear coordinates. Different from the previous work, not only the stream function and its first‐order partial derivatives but also the second‐order mixed partial derivative is treated as unknown variable in this work. Numerical examples, including a test problem with an analytical solution, three types of lid‐driven cavity flow problems with unusual shapes and steady flow past a circular cylinder as well as an elliptic cylinder with angle of attack, are solved numerically by the newly proposed scheme. For two types of the lid‐driven trapezoidal cavity flow, we provide the detailed data using the fine grid sizes, which can be considered the benchmark solutions. The results obtained prove that the present numerical method has the ability to solve the incompressible flow for complex geometry in engineering applications, especially by using a nonorthogonal coordinate transformation, with high accuracy.
CO2 capture and mineralization using carbide slag doped fly ash
Authors: Liu Rong , Wang Xiaolong , Gao Shiwang 
Published: November 2019

AbstractA novel direct gas–solid mineral carbonation process using carbide slag doped fly ash to capture and mineralize CO2 from flue gas was developed to overcome the barriers of long reaction time and large reactor size from aqueous processes. A laboratory‐scale fixed bed reactor with a thermogravimetric analyser and a pilot‐scale circulating entrained‐flow bed (CEB) rector system were constructed to investigate the intensification method and reaction parameters. The carbonation efficiency (ζCa [%]) was improved four times by carbide slag doped fly ash in a semi‐dry atmosphere; thus, the active calcium hydroxide from carbide slag and fly ash can react with CO2 in a thin liquid film through an ionic reaction route. The key reaction parameters, such as temperature, steam addition and water injection, were studied to promote Ca(OH)2 formation and to facilitate CO2 diffusion. As a result of the pilot‐scale experiment, carbonation efficiency achieved a maximum value of 55% with 15% steam addition in the feed and 6 kg h–1 water injection into CEB at 550 °C. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus
Authors: Levitsky Josh , Burrell Bryna E. , Kanaparthi Sai , Turka Laurence A. , Kurian Sunil , Sanchez‐Fueyo Alberto , Lozano Juan J. , Demetris Anthony , Lesniak Andrew , Kirk Allan D. , Stempora Linda , Yang Guang‐Yu , Mathew James M. 
Published: November 2019

BACKGROUND AND AIMS
As conversion from calcineurin inhibitor to sirolimus (SRL), a mechanistic target of rapamycin inhibitor (mTOR‐I), has been shown to enhance immunoregulatory profiles in liver transplant (LT) recipients (LTRs), mTOR‐I therapy might allow for increased success of immunosuppression (IS) withdrawal. Our aim was to determine if operational tolerance could be observed in LTRs withdrawn from SRL and if blood/graft tolerance biomarkers were predictive of successful withdrawal.

APPROACH AND RESULTS
We performed a prospective trial of SRL monotherapy withdrawal in nonimmune, nonviremic LTRs > 3 years post‐LT. SRL was weaned over ~6 months, and biopsies were performed 12 months postweaning or at concern for acute rejection. Twenty‐one LTRs consented; 6 were excluded due to subclinical acute rejection on baseline biopsy or other reasons, and 15 underwent weaning (age 61.3 ± 8.8 years; LT to SRL weaning 6.7 ± 3 years). Eight (53%) achieved operational tolerance (TOL). Of the 7 who were nontolerant (non‐TOL), 6 had mild acute rejection on biopsy near the end of weaning or at study end; 1 was removed from the trial due to liver cancer recurrence. At baseline preweaning, there were statistically increased blood tolerogenic dendritic cells and cell phenotypes correlating with chronic antigen presentation in the TOL versus non‐TOL groups. A previously identified biopsy gene signature accurately predicted TOL versus non‐TOL in 12/14 LTRs before weaning. At study end, biopsy staining revealed statistically significant increases in antigen‐presenting cell:leukocyte pairings, FOXP3+/CD4+ T cells, Tbet+/CD8+ T cells, and lobular dendritic cells in the non‐TOL group.

CONCLUSIONS
This study evaluated IS withdrawal directly from mTOR‐I therapy in LTRs and achieved > 50% operational tolerance. Preweaning gene expression and peripheral blood mononuclear cell profiling may be useful as predictors of successful mTOR‐I therapy withdrawal. NCT02062944.
Parental executive function as a predictor of parenting practices and children's executive function
Authors: Korucu Irem , Litkowski Ellen , Purpura David J. , Schmitt Sara A. 
Published: November 2019

AbstractThe family context has been identified as an important predictor of the development of children's executive function (EF). An emerging line of research demonstrates that parents' own EF is linked to their caregiving behaviours and their children's EF. However, researchers have yet to explore the extent to which parental EF is related to specific caregiving practices in the home that may be supportive of children's EF. In this study, we examined the extent to which parental EF is associated with children's EF and explored the role of general parenting practices as well as EF‐specific parenting activities in this relation using a sample of 197 preschoolers (50.3% male and 84.3% Caucasian) and their parents in the United States. Multivariate regressions indicated that parental EF was related to children's EF above and beyond general parenting and EF‐specific practices (β = .22, p = .003, CI [0.07, 0.36]). Additionally, a significant indirect relation emerged between parental EF and children's EF through EF‐specific activities (β = .04, CI [0.01, 0.10]). The potential importance of the family context for EF development and study implications are discussed.Highlights

The purpose was to examine the associations among parent's EF, children's EF, and general parenting and EF‐ specific practices.
Parent's engagement in EF‐specific activities mediated the relation between parental EF and children's EF
Parent's own EF skills as well their engagement in EF‐specific activities may promote the development of children's EF.
Overcoming Challenges on an International Project to Advance Systems Engineering
Authors: Davidz Heidi , Ferris T.L.J. , Henry Devanandham , Hilburn Thomas B. , Hutchison Nicole A.C. , Olwell David H. , Prun Daniel , Pyster Art , Roussel Jean‐Claude , Sillitto Hillary , Snoderly John , Squires Alice F. , Zemrowski Ken 
Published: November 2019

ABSTRACTThe Body of Knowledge and Curriculum to Advance Systems Engineering (BKCASE) project's dual product development cycle spanned a three‐year period from the September 2009 to December, 2012. During this timeframe, BKCASE authors met quarterly at various locations, primarily in various regions of the United States, but also in Stockholm, Sweden; Toulouse, France; London, England; and Rome, Italy (BKCASE, 2009–2019). The team successfully worked through challenges and differences to produce The Guide to the Systems Engineering Body of Knowledge (SEBoK) wiki and a Graduate Reference Curriculum for Systems Engineering (GRCSE) publication. This article is a collection of personal stories from the team members that focus on overcoming obstacles to successfully produce the final published products.
Globalizing the Certification of Systems Engineers
Authors: Wright Courtney 
Published: November 2019

ABSTRACTWhat defines an international airport? Flights to and from other countries? Big runways and high volume of passengers? US definitions of international airports focus on the facility's ability to process passengers entering from another country. They do not look at whether aircraft can or do enter that port, just whether their passengers are allowed to leave the airport if it is their first port of entry in the US. It is about what can, theoretically, be done with people from other countries, rather than how well people around the globe are actually interacting.How do we define an international professional society or its international certification program? We might start by looking at the three factors listed above: May people from more than one country participate? Can people from more than one country participate? And, do people from more than one country participate? This “more than one country” bar is pretty easy to meet, thanks to the UK, so let's move to all countries. This is a much greater challenge and the logic behind referring to INCOSE as a global certification program rather than the easier international. In our context, international means including some other countries, often those with similar cultures or technologies, where global is both broader and deeper, and for us, this includes modifying our baseline certification practices in response to feedback from other cultures.