bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation
Authors: Sakano Masayoshi , Tomita Yoshinobu , Kanazawa Takumi , Ishibashi Sachiko , Ikeda Masumi , Oshita Haruna , Hananoi Yuri , Kato Yuki , Yamamoto Kurara , Furukawa Asuka , Kinoshita Mayumi , Haruki Shigeo , Tokunaga Masanori , Kinugasa Yusuke , Kurata Morito , Kitagawa Masanobu , Ohashi Kenichi , Yamamoto Kouhei 
Published: December 2024

BackgroundEsophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a leading cause of cancer-related death and has a poor prognosis. Despite the advancements in multidisciplinary therapies, resistance to conventional treatments warrants the development of novel therapeutic strategies. Ferroptosis, a form of cell death dependent on intracellular iron, has emerged as a potential mechanism for targeting cancer cells resistant to apoptosis. Guanosine triphosphate cyclohydrolase 1 (GCH1) has been identified as a novel antagonist of ferroptosis; however, its role in ESCC remains unclear. This study aimed to investigate the correlation between the expression and accumulation of the lipid peroxidation markers and regulators, including GCH1, in patients with ESCC and examined their prognostic significance. Furthermore, we investigated the relationship between lipid peroxidation regulators and cell death using an in vitro system to establish the basis for new therapeutic strategies.MethodsWe retrospectively analyzed 312 patients with ESCC who underwent radical esophagectomy at the Tokyo Medical and Dental University. Immunohistochemistry was performed to evaluate the expression of lipid peroxidation markers (4-hydroxy-2-nonenal) and regulators (glutathione peroxidase 4 [GPX4], ferroptosis suppressor protein 1 [FSP1], and GCH1). The correlation between these markers, clinicopathological features, and overall survival was assessed. In vitro experiments were performed using KYSE-150 cells to investigate the effects of GCH1 knockdown and overexpression on cell proliferation, cisplatin-induced cell death, and ferroptosis.ResultsLow GCH1 expression was significantly associated with a poor prognosis in patients with ESCC. GCH1 expression correlated with lymph node metastases, vessel invasion, and the pathological tumor stage. In vitro, GCH1-knockdown cells exhibited increased proliferation and resistance to cisplatin-induced cell death, whereas GCH1 overexpression reduced cell proliferation. Simultaneous inhibition of GPX4 and FSP1 induced mild cell death; however, GCH1 knockdown dramatically enhanced ferroptosis, suggesting a synergistic effect.ConclusionGCH1 is a critical prognostic factor for ESCC and plays a significant role in the regulation of cell proliferation and ferroptosis. Targeting GCH1 in combination with GPX4 and FSP1 inhibitors may offer a novel therapeutic strategy for overcoming resistance in ESCC. Further studies are warranted to elucidate the involved molecular mechanisms and validate these findings in vivo.
Case report: Carcinosarcoma of uterus in nulliparous women
Authors: Sun Feiyue , Li Xuelei , Kang Luyao , Wang Yiran , Li Hongyu , Zhu Hai 
Published: December 2024

BackgroundUterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a cancer that include both carcinomatous and sarcomatous components, resembling endometrial carcinoma. A 55-year-old woman was admitted to the hospital with postmenopausal vaginal bleeding. Gross examination of the specimen revealed brittle tissue in the fundus and the left wall of the endometrium. Postoperative pathology revealed a mixture of well-differentiated endometrioid adenocarcinoma and osteosarcoma. The patient was never given birth, which may be relevant to the diagnosis. Literature review suggests that being nulliparous may be a significant risk factor for developing uterine carcinosarcoma.Case descriptionIn December 2023, a 55-year-old female patient was admitted to the hospital with postmenopausal vaginal bleeding. Hysteroscopic surgery was performed, and the postoperative pathology showed endometrial cancer accompanied by ossified tissue with necrosis. The immunohistochemical results indicated positive Estrogen receptors (ER), positive Progesterone receptors (PR), ki67 positivity at 70%, negative PTEN, mutated positive p53, focal positive Pax-8, positive SATB2, positive Cytokeratin 7 (CK7), positive EMA and positive Vimentin (Vim). The patient was diagnosed with Uterine carcinosarcoma. On December 18, 2023, the patient underwent partial vaginal resection, bilateral salpingo-oophorectomy, pelvic lymph node dissection, and a sub-extensive laparoscopic hysterectomy. Postoperatively, the patients received radiotherapy and four cycles of chemotherapy in the DC regimen. As of July 2024, laboratory and impact test results showed no tumor recurrence. The patient’s disease-free survival (DFS) was seven months.ConclusionThe rate of childless in patients with uterine carcinosarcoma is at a high level.
Machine learning algorithms for the early detection of bloodstream infection in children with osteoarticular infections
Authors: Liu Yuwen , Wu Yuhan , Zhang Tao , Chen Jie , Hu Wei , Sun Guixin , Zheng Pengfei 
Published: December 2024

BackgroundBloodstream infection (BSI) poses a significant life-threatening risk in pediatric patients with osteoarticular infections. Timely identification of BSI is crucial for effective management and improved patient outcomes. This study aimed to develop a machine learning (ML) model for the early identification of BSI in children with osteoarticular infections.Materials and methodsA retrospective analysis was conducted on pediatric patients diagnosed with osteoarticular infections admitted to three hospitals in China between January 2012 and January 2023. All patients underwent blood and puncture fluid bacterial cultures. Sixteen early available variables were selected, and eight different ML algorithms were applied to construct the model by training on these data. The accuracy and the area under the receiver operating characteristic (ROC) curve (AUC) were used to evaluate the performance of these models. The Shapley Additive Explanation (SHAP) values were utilized to explain the predictive value of each variable on the output of the model.ResultsThe study comprised 181 patients in the BSI group and 420 in the non-BSI group. Random Forest exhibited the best performance, with an AUC of 0.947 ± 0.016. The model demonstrated an accuracy of 0.895 ± 0.023, a sensitivity of 0.847 ± 0.071, a specificity of 0.917 ± 0.007, a precision of 0.813 ± 0.023, and an F1 score of 0.828 ± 0.040. The four most significant variables in both the feature importance matrix plot of the Random Forest model and the SHAP summary plot were procalcitonin (PCT), neutrophil count (N), leukocyte count (WBC), and fever days.ConclusionsThe Random Forest model proved to be effective in early and timely identification of BSI in children with osteoarticular infections. Its application could aid in clinical decision-making and potentially mitigate the risk associated with delayed or inaccurate blood culture results.
A pilot study of the utility of a hospital-based school program for pediatric patients with cardiac diagnoses
Authors: Thibodaux Lia K. , Orr Ashley L. , Reisinger Debra L. , Fodstad Jill , Xu Guang , Wikel Kristin , Curtin Michelle 
Published: December 2024

IntroductionPediatric patients with complex cardiac diagnoses are at increased risk for physical, cognitive, and developmental complications. Formalized school support [i.e., individualized education programs (IEPs), Section 504 Accommodation Plans (Section 504 Plans)] that addresses the needs of these patients is necessary, and hospital-based school programs (HBSPs) have the potential to bolster the acquisition of academic support. In this pilot study, we look at the impact of one such HBSP.MethodsRetrospective demographic and school support data for pediatric cardiac patients were analyzed.ResultsOur sample included 29 pediatric cardiac patients spanning two academic years. These patients had 100 HBSP encounters and 82 inpatient and 12 outpatient encounters, with 68.9% of patients having multiple encounters in a single year and 44.8% of patients being seen in both years. The HBSP made recommendations for patients to receive IEPs (N = 8) and Section 504 Plans (N = 13). The patients also submitted requests for medical homebound(N = 27), obtaining releases of information (N = 39), submitting medical reports (N = 10), and completing certificates of incapacity (N = 7). Statistical analyses revealed no significant relationships with patients entering or receiving a recommendation for an IEP or Section 504 Plan in any of their encounters with the HBSP on the basis of sex, race/ethnicity, school level, or rates of encounters in this sample.DiscussionSimilar to previous studies, these patients had high rates of IEPs/Section 504 Plans in place and continued to receive school recommendations through the HBSP. A high use of the HBSP was seen in the total number of encounters and communications (i.e., submitting to the school of record requests for classroom placement changes via medical homebound). Working with the HBSP provided access to information, formal support recommendations, and communication between medical and school settings in the form of changes in school status.
Reference ranges for complete blood count in children and adolescents with Down syndrome
Authors: Lattuada Martina , Capitoli Giulia , Casati Marco , Lazzerotti Alessandra , Maglia Oscar , Ferrari Giulia Maria , Fossati Chiara , Biondi Andrea , Cattoni Alessandro , Corti Paola 
Published: December 2024

IntroductionDown syndrome (DS) is linked to unique hematopoietic characteristics that affect complete blood count (CBC) parameters. Accurate reference ranges are essential for proper CBC interpretation in this population.MethodsThis retrospective study analyzed 2,627 CBCs from 481 DS patients, aged 31 days to 18 years, at a tertiary care center in Italy. Patients with significant comorbidities were excluded to ensure a homogeneous group.ResultsCBC parameters were assessed to establish age- and sex-specific reference ranges. Centile charts were developed for each parameter, and an online tool was created to allow clinicians to compare individual CBC results with the new ranges. Comparisons with the general pediatric population revealed significant differences, particularly in hemoglobin, hematocrit, and mean corpuscular volume, which were higher in DS (p &lt; 0.001). In contrast, a significant percentage of CBCs showed white blood cell counts below the 2.5th centile of healthy controls (p &lt; 0.001), except for the 31 days–1 year age group. A similar trend was observed for lymphocytes (p &lt; 0.001) in the 1-18 years group.DiscussionThese newly established DS-specific reference ranges provide clinicians with a crucial tool for evaluating CBC results, potentially reducing unnecessary tests and emphasizing the need for tailored clinical assessment in managing this unique population.
Ophthalmic corticosteroids-related adverse events: the FDA adverse event reporting system (FAERS) database pharmacovigilance study
Authors: Liu Chengzhi , Wang Xinyu , Cao Xusheng 
Published: December 2024

BackgroundCorticosteroids are extensively used in ophthalmology, particularly for treating various inflammatory conditions. Despite their effectiveness, prolonged or high-dose corticosteroid use is associated with significant adverse drug reactions (ADRs), such as increased intraocular pressure, cataract formation, and secondary infections. However, there is currently no systematic study comparing the side effects of ophthalmic corticosteroids. This study aims to investigate the safety profiles of ophthalmic corticosteroids through pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS) database.MethodsWe conducted a retrospective analysis of ADR reports related to commonly used ophthalmic corticosteroids from the FAERS database, covering the period from Q1 2004 to Q4 2023. Clinical features such as gender, age, administration route, and dosage form were also analyzed. Signal detection methods, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and the Multi-Item Gamma Poisson Shrinker (MGPS), were used to identify potential safety signals.ResultsA total of 9,854 ADRs related to ophthalmic corticosteroids were retrieved, with the most frequently reported drugs being Ozurdex (1,784 cases), Lotemax (3,239 cases), and Durezol (2,789 cases). Women accounted for a higher proportion of ADRs across most corticosteroids. ADR induction time analysis results showed that ADRs tend to occur in the early stages of drug use. The most common ophthalmic ADRs identified included eye inflammation, cataract, visual impairment, uveitis, eye pain, blurred vision, and retinal detachment. Additionally, Maxidex has been linked to endocrine disorders, while Ozurdex, Iluvien, and Triesence exhibited significant signals for product issues, likely related to their intraocular injection procedures. Notably, cataract was the most common PT among these drugs.ConclusionOur study reveals significant safety concerns related to using ophthalmic corticosteroids, particularly regarding adverse reactions that can impact visual function. These findings highlight the need for careful monitoring and individualized treatment plans to minimize the risk of ADRs in patients receiving corticosteroid therapy. Future studies combining FAERS data with large-scale clinical research are needed to explore these safety concerns further.
Hypoalbuminemia and cisplatin-induced acute kidney injury
Authors: Yin Wen-Jun , Huang Yu-Jie , Zhu Qing , Lin Xiao-Qing , Piao Hui-Ling , Yu Qian-Qian , Lai Chang-Hong , Zhou Guang-Liang , Zhou Ling-Yun , Liu Kun , Zuo Xiao-Cong , Zuo Shan-Ru 
Published: December 2024

BackgroundCisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent. Our aim is to confirm the association between hypoalbuminemia and CIA through a meta-analysis and a dual-center real-world data study.MethodsFirst, we used a random-effects meta-analysis to summarize the odds ratio (OR) of the risk relationship between hypoalbuminemia and CIA. Then, we conducted a retrospective analysis of patients using cisplatin from Xiangya Third Hospital of Central South University (2014–2023) and Hunan Cancer Hospital (2019–2023) to analyze the relationship between hypoalbuminemia and CIA.ResultsThe meta-analysis, which included six studies involving 4,359 cases, showed that hypoalbuminemia is associated with an increased risk of CIA (OR, 2.13; 95% CI, 1.37–3.32). A total of 5,452 and 25,214 patients from Xiangya Third Hospital and Hunan Cancer Hospital, respectively, were included. Both centers found a significant association between hypoalbuminemia and an increased risk of CIA (OR, 2.76; 95% CI, 1.94–3.93; OR, 2.88; 95% CI, 2.17–3.81), and the sensitivity analysis results were consistent.ConclusionThrough meta-analysis and dual-center real-world data studies, we confirmed that hypoalbuminemia is an independent risk factor for CIA. Therefore, it is recommended that patients using cisplatin undergo serum albumin level testing and regular monitoring during treatment. Actively adjusting albumin levels may reduce the risk of CIA.
Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study
Authors: Huang Xue-rong , Wang Lian , Liang Guo-bao , Huang Sheng-qian , Feng Bao-ying , Zhu Lu , Fan Xu-fang , Yao Mu-lin , Zhang Jing , Wang Meng-jiao , Zheng Zhi , Zhu Yao , Duan Wen-li , Li Zhan-kui , Mao Jian , Ma Li , Xu Fa-lin , Wu Fan , Wei Qiu-fen , Liu Ling , Lin Xin-zhu 
Published: December 2024

BackgroundBronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.ObjectiveTo assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).MethodsWe conducted a retrospective cohort study of infants born at 22–32 weeks gestation with PPHN or HRF, treated with iNO for over 3 h. PSM matched groups by gestational age, birth weight, and gender, etc. Multivariate logistic regression evaluated the association between iNO treatment and BPD outcomes to identify influencing factors, while Restricted Cubic Spline (RCS) and mediation analysis examined iNO dose effects and potential mediators like mechanical ventilation time and oxygenation index (OI).ResultsA higher initial iNO dose was significantly associated with a reduced risk of BPD Grade Ⅱ-Ⅲ (adjusted OR = 0.68, 95% CI: 0.52–0.89, p &lt; 0.01). Additionally, administration of iNO within the first 7 days of life was identified as an important influencing factor No significant mediation effects were observed for factors such as mechanical ventilation time and OI.ConclusionA higher initial iNO dose within the first 7 days was associated with a reduced risk of BPD Grade Ⅱ-Ⅲ in VPI with PPHN or HRF.
Prevalence of depression and anxiety among university students in Jeddah, Saudi Arabia: exploring sociodemographic and associated factors
Authors: Malebari Azizah M. , Alamoudi Saeed O. , AL-Alawi Talal I. , Alkhateeb Anas A. , Albuqayli Adnan S. , Alothmany Hamzah N. 
Published: December 2024

IntroductionPrevious studies have shown that mental health issues such as depression and anxiety are on the rise globally, particularly among university students. The aim of this study is to assess the prevalence of depressive and anxiety symptoms among university students, and the associated potential risk factors, in Jeddah, Saudi Arabia.MethodsA cross-sectional questionnaire study was conducted in a sample of 728 students who anonymously completed three sets of questionnaires: a sociodemographic and lifestyle information questionnaire, the Patient Health Questionnaire-9 (PHQ-9) to screen for depressive symptoms and the Generalized Anxiety Disorder-7 (GAD-7) scale to screen for anxiety symptoms.ResultsIn a survey of 728 students, 81.5% reported depression and 63.6% anxiety, with no difference between medical and non-medical majors. Regular exercise, a history of psychological disorders, a diagnosis of chronic illness, and the use of antidepressant medications were significant indicators of depression. Significant anxiety markers included female gender, a diagnosis of chronic illness, a history of psychological disorders, the use of antidepressant medications, and smoking. Surprisingly, we did not observe any significant differences between the prevalence of depression or anxiety symptoms and common risk predictors, such as poor academic performance, low family income, and year of study.ConclusionDepression and anxiety had a high prevalence among undergraduates, regardless of their field of study; therefore, we recommend the implementation and expansion of community-based mental health prevention programs and mentorship programs. Universities with counseling programs should identify and eliminate factors that contribute to depression and anxiety.
Accuracy of self-reported foot strike pattern detection among endurance runners
Authors: Vincent Heather K. , Coffey Kyle , Villasuso Aiden , Vincent Kevin R. , Sharififar Sharareh , Pezzullo Lydia , Nixon Ryan M. 
Published: December 2024

IntroductionFoot strike pattern is often associated with running related injury and the focus of training and rehabilitation for athletes. The ability to modify foot strike pattern depends on awareness of foot strike pattern before being able to attempt change the pattern. Accurate foot strike pattern detection may help prevent running related injury (RRI) and facilitate gait modifications and shoe transitions. The purposes of this study were to determine the accuracy of self-reported foot strike pattern among endurance runners, to identify what factors were predictive of accurate foot strike detection and recent RRI.MethodsThis was a retrospective, cross-sectional study which included endurance runners (N = 710; 51.5% female; 35.4 ± 15.5 years; 51.6% were training competitively at the time of testing) with different running injury histories. Runners self-reported foot strike pattern [rearfoot, non-rearfoot (mid or forefoot), or “don't know”] and information about shoewear specifics. All runners performed a single session of running at self-selected speed on an instrumented treadmill with 3D motion capture and high-speed filming that verified actual foot strike. Logistic regression was used to predict accuracy of foot strike detection and RRI.ResultsOverall accuracy of foot strike detection was low (42.7%; p &lt; 0.01). Self-reported foot strike was 28.3% for rearfoot, 47.0% for nonrearfoot forefoot strike and 24.6% did not know. Biomechanical analyses actually showed that 34% of rearfoot strikers accurately detected rearfoot strike, while 69.5% of non-rearfoot strikers self-reported accurate non-rearfoot strike (p &lt; 0.05). Runners who “did not know” their strike had the highest prevalence of RRI compared to runners who self-reported nonrearfoot or rearfoot strike (73% vs. 56% and 58%; p &lt; .001). After accounting for several variables, shoe heel-to-toe drop was a consistent predictor of accurate strike detection [OR = 0.93 (0.88–0.99); p = 0.026] and RRI in last six months [OR = 1. 1 (1.01–1.17); p = 0.018]. RRI were also predicted by recent shoe change [OR = 2.8 (1.7–4.6); p &lt; 0.001].DiscussionAccurate detection of actual foot strike by endurance runners varies by the actual foot strike type determined during testing and is associated shoe characteristics. These findings demonstrate the importance of accurately identifying foot strike pattern and recommending footwear as a factor if planning to use retraining to alter foot strike pattern.
Nutrition in Cancer Patients
Authors: Li Zhaoping , Heber David 
Published: December 2024

Abstract:
Nutrition interventions have traditionally been used to support patients with malnutrition secondary to cancer and cancer treatments and more recently have been utilized in the primary and secondary prevention of common forms of cancer. A fundamental understanding of the nutrient metabolism of patients with cancer is essential for providing optimal nutrition to best support the patients while suppressing cancer growth and enhancing the body’s response to treatment. In this article, the metabolism abnormality of patients with cancer is reviewed together with nutritional assessment, dietary intervention, and nutritional therapy for cancer patients.
Инновации в банковском секторе
Authors: Ахмадеев А.М. 
Published: December 2024

Тема статьи выбрана не случайно, ведь, по мнению автора, в результате пандемии коронавируса финансовый сектор совершил беспрецедентный технологический скачок – за несколько месяцев удалось достичь целей, запланированных на ближайшие несколько лет. Электронный банкинг динамично развивается, меняется и способ общения с клиентами, при этом на первое место выходит удобство и экономия времени.
The topic of the article was not chosen by chance, because, according to the author, as a result of the coronavirus pandemic, the financial sector made an unprecedented technological leap – in a few months it was possible to achieve the goals planned for the next few years. Electronic banking is dynamically developing, and the way of communicating with customers is changing, putting convenience and time savings in the first place.