bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled trial comparing the clinical efficacy and cost-effectiveness of eye movement desensitization and reprocessing (EMDR) and integrated EMDR-Dialectical Behavioural Therapy (DBT) in the treatment of patients with post-traumatic stress disorder and comorbid (Sub)clinical borderline personality disorder: study design
Authors: Snoek Aishah , Beekman Aartjan T. F. , Dekker Jack , Aarts Inga , van Grootheest Gerard , Blankers Matthijs , Vriend Chris , van den Heuvel Odile , Thomaes Kathleen 
Published: August 2020

Abstract
Background
Comorbidity between Posttraumatic Stress Disorder (PTSD) and Borderline Personality Disorder (BPD) is high. There is growing motivation among clinicians to offer PTSD treatments – such as Eye Movement Desensitization and Reprocessing (EMDR) - to patients with PTSD and comorbid BPD. However, a large subgroup with comorbid BPD does not sufficiently respond to PTSD treatment and is more likely to be excluded or to dropout from treatment. Dialectical Behaviour Therapy (DBT) for BPD is well established and although there is some evidence that DBT combined with DBT Prolonged Exposure (DBT + DBT PE) is twice as effective in reducing PTSD symptoms than DBT alone, the comparative efficacy of integrated PTSD-DBT and PTSD-only treatment has not been investigated yet. The current study will therefore evaluate the comparative clinical efficacy and cost-effectiveness of EMDR-DBT and EMDR-only in patients with PTSD and comorbid (sub)clinical BPD. Moreover, it is not clear yet what treatment works best for which individual patient. The current study will therefore evaluate neurobiological predictors and mediators of the individual response to treatment.

Method
A randomized controlled trial comparing the clinical efficacy and cost-effectiveness of integrated EMDR-DBT (n = 63) and EMDR-only (n = 63) in treatment-seeking adult patients with PTSD and comorbid (sub)clinical BPD. In addition, neurobiological predictors and mediators of treatment outcome, such as hair cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status, are measured through hair and blood samples.

Discussion
This is the first study to compare the clinical efficacy and cost-effectiveness of integrated EMDR-DBT and EMDR-only in patients with PTSD and comorbid (sub)clinical BPD, while simultaneously identifying individual predictors and mediators of treatment response. Results will reveal which treatment works best for which individual patient, thereby guiding individual treatment choices and personalizing psychiatry.

Trial registration

Clinical Trials, NCT03833453. Retrospectively registered, 15 March 2019.
HIV incidence declines in a rural South African population: a G-imputation approach for inference
Authors: Vandormael Alain , Cuadros Diego , Dobra Adrian , Bärnighausen Till , Tanser Frank 
Published: August 2020

Abstract
Background
Ad hoc assumptions about the unobserved infection event, which is known only to occur between the latest-negative and earliest-positive test dates, can lead to biased HIV incidence rate estimates. Using a G-imputation approach, we infer the infection dates from covariate data to estimate the HIV incidence rate in a hyper-endemic South African setting.

Methods
A large demographic surveillance system has annually tested a cohort of HIV-uninfected participants living in the KwaZulu-Natal province. Using this data, we estimated a cumulative baseline hazard function and the effects of time-dependent covariates on the interval censored infection dates. For each HIV-positive participant in the cohort, we derived a cumulative distribution function and sampled multiple infection dates conditional on the unique covariate values. We right censored the data at the imputed dates, calculated the annual HIV incidence rate per 100 person-years, and used Rubin’s rules to obtain the 95% confidence intervals.

Results
A total of 20,011 uninfected individuals with a repeat HIV test participated in the incidence cohort between 2005 and 2018. We observed 2,603 infections per 58,769 person-years of follow-up among women and 845 infections per 41,178 person-years of follow-up among men. Conditional on age and circumcision status (men only), the female HIV incidence rate declined by 25%, from 5.0 to 3.7 infections per 100 person-years between 2014 and 2018. During this period, the HIV incidence rate among men declined from 2.1 to 1.1 infections per 100 person-years—a reduction of 49%. We observed similar reductions in male and female HIV incidence conditional on condom-use, marital status, urban residential status, migration history, and the HIV prevalence in the surrounding community.

Conclusion
We have followed participants in one of the world’s largest and longest running HIV cohorts to estimate long-term trends in the population-wide incidence of infection. Using a G-imputation approach, we present further evidence for HIV incidence rate declines in this hyper-endemic South African setting.
Evaluating prescribing competencies covered in a Canadian-accredited undergraduate pharmacy program in Qatar: a curriculum mapping process
Authors: Abdallah Oraib , Ageeb Rwedah Anwar , Elkhalifa Wishah Hamza Imam , Zolezzi Monica , El-Awaisi Alla , Diab Mohammad Issam , Awaisu Ahmed 
Published: August 2020

Abstract
Background
The objective of this study was to evaluate the existing Bachelor of Science in Pharmacy [BSc (Pharm)] curriculum at Qatar University College of Pharmacy (QU CPH), for addressing international prescribing competencies.

Methods
The Australian National Prescribing Service (NPS MedicineWise) Competencies Required to Prescribe Medicines framework (the Prescribing Competencies Framework) was used in the BSc (Pharm) curriculum mapping process. The NPS MedicineWise Prescribing Competencies Framework outlines seven competency areas that are essential for pharmacist prescribing. The first mapping activity assessed the learning outcomes (LOs) of 62 courses within the BSc (Pharm) curriculum for covering and addressing the NPS MedicineWise competencies. The second mapping activity involved matching the LOs identified to address the NPS MedicineWise prescribing competencies, to the 2017 Association of Faculties of Pharmacy of Canada (AFPC) educational outcomes, on which the QU CPH BSc (Pharm) program is based. The AFPC educational outcomes address seven key program-level learning outcomes.

Results
The QU CPH BSc (Pharm) curriculum addresses most of the prescribing competencies listed in the NPS MedicineWise Prescribing Competencies Framework. However, gaps were identified in the curricular content and in the LOs that were related, but not restricted, to the following: electronic prescribing, physical examinations/preparing patients for investigations, and policies/procedures and quality assurace related to prescribing. Other gaps identified include legislative and workplace requirements for obtaining consent to access confidential patient's health information.

Conclusion
The curriculum mapping exercise provided evidence that, for the most part, the existing BSc (Pharm) curriculum at QU CPH prepares pharmacy graduates for prescribing. However, there are areas that need better alignment between the taught curriculum and training on prescribing in practice. The results of this study are important to consider if pharmacist prescribing is to be implemented in Qatar.
Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
Authors: Lu Chengli , Ma Zhiyuan , Cheng Xiaoming , Wu Huichao , Tuo Biguang , Liu Xuemei , Li Taolang 
Published: August 2020

AbstractBreast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treatments are surgery and chemotherapy; no targeted standard treatment options are available. Therefore, it is urgent to find a novel and effective therapeutic target. As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC and may provide new tumor biomarkers and help in the development of novel targeted therapies.
Cultural adaptation and psychometric evaluation of the Swedish version of the Reproductive Concerns After Cancer (RCAC) scale
Authors: Anandavadivelan Poorna , Wiklander Maria , Eriksson Lars E. , Wettergren Lena , Lampic Claudia 
Published: August 2020

Abstract
Background
Reproductive concerns are common among young cancer survivors and include worries related to different aspects of fertility and parenthood. The Reproductive Concerns After Cancer (RCAC) scale is an 18-item scale with six dimensions, developed to capture a variety of such concerns. The aim of the present study was to describe the cultural adaptation of the RCAC scale into Swedish and evaluate its psychometric properties among young women who have undergone treatment for cancer.

Methods
The RCAC was forward translated from English into Swedish and assessed for cultural adaptation based on a two-panel approach followed by cognitive interviews with the target group. For the psychometric evaluation, a Swedish cohort of 181 female young adult breast cancer survivors completed a survey including the RCAC scale approximately 1.5 years post-diagnosis. Psychometric properties were examined by analyses of construct validity (confirmatory factor analysis and convergent validity), data quality (score distribution, floor and ceiling effects), reliability and known-groups validity.

Results
The confirmatory factor analysis yielded an acceptable fit (RMSEA 0.08, SRMR 0.09, CFI 0.92). Convergent validity was demonstrated by a negative correlation of moderate size (− 0.36) between the RCAC total score and the emotional function scale of the EORTC QLQ-C30. Reliability measured with Revelle Ω total was satisfactory (0.73–0.92) for five of the dimensions, and poor for the dimension Becoming pregnant (Revelle Ω total = 0.60); Cronbach’s alpha showed a similar pattern. Known-groups validity was indicated by significant RCAC mean score differences (MD), reflecting more concerns among women with a certain (MD 4.56 [95% CI 3.13 to 5.99]) or uncertain (MD 3.41 [95% CI 1.68 to 5.14]) child wish compared to those with no wish for (additional) children.

Conclusion
The translation and cultural adaptation of the Swedish RCAC has resulted in a scale demonstrating construct and known-groups validity, and satisfactory reliability for five of six dimensions. The dimension Becoming pregnant showed non-optimal internal consistency and should undergo further evaluation. The Swedish RCAC is recommended to be used in research settings for measurement of concerns related to fertility and parenthood in young women with cancer.
Challenges and opportunities of transgenic agricultural products in Iran: convergence of perspectives using Delphi technique
Authors: Badghan Fatemeh , Namdar Razieh , Valizadeh Naser 
Published: August 2020

Abstract
Background
Widespread production and use of transgenic products across the world in recent decade has led to different reactions and point of views. Iran is also one of the consumers of these products. However, there has been an ever-increasing controversy between supporters and opponents of the use of these products in Iran and no constructive agreement has been attained on this issue. Accordingly, the main goal of present study was to determine the challenges and opportunities of transgenic agricultural products in biotechnology and plant breeding specialists’ point of view.

Methodology
Delphi technique was used to achieve this goal. The statistical population was Iranian specialists in plant breeding, biotechnology, and genetic modification. The snowball sampling approach was employed to select the samples.

Results
In general, 16 concepts in the dimension of opportunities and 25 concepts in the dimension of the challenges were identified. Analyzing the agreement rates showed that the panel of experts agree most on 14 concepts out of 16 concepts identified for opportunities. In the dimension of challenges for transgenic products, only 17 concepts received acceptable agreement scores (over 80%).

Conclusion
In general, categorizing the concepts of transgenic products’ opportunities led to identification of two main aspects namely “food security” and “biosafety”. Challenges were also categorized into four strata of structural, educational, cognitive, and informational challenges. In addition, it should be mentioned that the lack of familiarity with methods, goals, and results of genetic engineering and gene transferring methods in transgenic plants is the most important aspect of people’s concern. Although it is not possible to get full knowledge about genetic engineering and genetic manipulation methods for all those who are the consumers of transgenic products, their awareness and recognition about the goals and positive/negative effects of the use of these products can be increased using specific strategies. For instance, one of the strategies is to focus and invest on mass media that which provides high availability, vast coverage, and low-cost. Accordingly, mass media (such as radio and television) can act as the best educational and informational tools for development and application of transgenic plants.
Histological study of sheep skin transformation during the recreation of historical parchment manufacture
Authors: Fourneau Marc , Canon Caroline , Van Vlaender Daniel , Collins Matthew J. , Fiddyment Sarah , Poumay Yves , Deparis Olivier 
Published: August 2020

Abstract
We report a simple histological study on skin biopsies from young domestic sheep following each step in transformation from skin to parchment production. During the recreation of historical parchment manufacture, histological analyses were conducted; before and after lime treatment, hair removal, and stretching. Sections were fixed and stained using a variety of histological stains to identify the presence of different molecular classes and the fibrous proteins, collagen and elastin. The results reveal surprisingly few histological changes in most steps in the production process. However, very visible changes in the supramolecular ordering of skin macromolecules (elastin, collagen) occur during the final stage of parchment production when stretched on the frame. Collagen fibres and hair follicles were all strongly re-oriented in the direction of strain. Surprisingly despite the thinness of the lambskin and the exhaustive treatment in lime, not all fats were saponified and even in the final product Oil Red O stained fat bodies were detectable on the hair side of the skin. We believe this study will help compensate for the lack of sources on microscopic changes in parchment during the recreation of its historical manufacture.
The source detection of 28 September 2018 Sulawesi tsunami by using ionospheric GNSS total electron content disturbance
Authors: Liu Jann-Yenq , Lin Chi-Yen , Chen Yuh-Ing , Wu Tso-Ren , Chung Meng-Ju , Liu Tien-Chi , Tsai Yu-Lin , Chang Loren C. , Chao Chi-Kuang , Ouzounov Dimitar , Hattori Katsumi 
Published: August 2020

AbstractThe 28 September 2018 magnitude Mw7.8 Palu, Indonesia earthquake (0.178° S, 119.840° E, depth 13 km) occurred at 10:02 UTC. The major earthquake triggered catastrophic liquefaction, landslides, and a near-field tsunami. The ionospheric total electron content (TEC) derived from records of 5 ground-based global navigation satellite system (GNSS) receivers is employed to detect tsunami traveling ionospheric disturbances (TTIDs). In total, 15 TTIDs have been detected. The ray-tracing and beamforming techniques are then used to find the TTID source location. The bootstrap method is applied in order to further explore the possible location of the tsunami source based on results of the two techniques, which show the beamforming technique has a slightly better performance on finding possible locations of the tsunami source. Meanwhile, the circle method is employed to examine tsunami signatures of the sea-surface height and video records, and find possible tsunami origin locations. The coincidence of the TTID source location and the tsunami location shows that the ionospheric TEC recorded by local ground-based GNSS receivers can be used to confirm the tsunami occurrence, find the tsunami location, and support the tsunami early warning.
Identity evolution of STEM teachers in Egyptian STEM schools in a time of transition: a case study
Authors: El Nagdi Mohamed , Roehrig Gillian 
Published: August 2020

Abstract
Background
The study was initiated as a response to the growing Science, Technology, Engineering, and Mathematics (STEM) experience in Egypt in terms of the growing number of schools, number of students admitted, and the effect of this experience on the overall education system in the country. Viewing teachers as the backbone of the STEM experience and teaching as a relational sociocultural practice (Biesta, G. & Stengel, B. (2016) AREA Handbook of research on teaching, 5th edition), this research explores the evolution of teachers’ STEM identity during their professional journey in the Egyptian STEM education reform initiative.

Aim
The purpose of this study is to explore the dynamic dialogical interaction between the different factors impacting the development/evolution of the STEM teachers’ identity. The study is guided by the following research questions:

How did Egyptian STEM teachers’ identity evolve over the course of the STEM experience in model STEM schools in Egypt?

How did the political and structural characteristics of the STEM schools and teachers developing STEM identities interact and co-evolve?

What do Egyptian STEM teachers identify as being important characteristics of STEM teachers

Methodology
A multiple holistic case study design was used to explore the research questions within the bounded context of an established Egyptian STEM school.

Methods
Data for this study were drawn from (1) semi-structured interviews conducted with seven teachers from an Egyptian STEM school and (2) document analysis of Ministry of Education decrees and the published reports of Education Consortium for the Advancement of STEM in Egypt.

Results
Using inductive and deductive data analysis, teachers were found to have undergone a deep transformative change process from a traditional teacher into teachers with a progressive mindset and student-centered classroom practices. The teachers developed strong conceptualizations of the STEM education, stressed the importance of collaboration, critical thinking, and motivation for teachers seeking to work in a STEM setting, and considered themselves moving towards established STEM teachers’ identity.

Conclusion
This study concluded that STEM teachers’ identity can be viewed as a dialogical, dynamic, and evolving process that results from the interaction of personal and professional traits within new educational experiences exemplified by the new and different experiences in their STEM schools.
Despite several challenges, such as limited resources and influence from the bureaucracy and norms of the traditional education system, the teachers still persist in their professional growth and desire to impact the larger context of the Egyptian education system.
Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review
Authors: da Cruz Natasha Ferreira Santos , Polizelli Murilo Ubukata , Cezar Laís Maia , Cardoso Emmerson B. , Penha Fernando , Farah Michel Eid , Rodrigues Eduardo B. , Novais Eduardo A. 
Published: August 2020

AbstractTo provide information on the effects of phosphodiesterase type 5 (PDE5) inhibitors on choroidal vessels and central serous chorioretinopathy (CSC) and possible implications for development of exudative age-related macular degeneration (AMD). Two independent investigators conducted a qualitative review of PubMed to identify studies on the choroidal effect of PDE5 inhibitors in June 2019. The search used key words that included PDE5 inhibitors, sildenafil, tadalafil, vardenafil, choroid, choroidal flow, choroidal vessels, choroidal thickness, CSC, AMD or a combination. Only studies which assessed choroidal findings were included. Many ocular diseases are related to changes in choroidal thickness and perfusion. Patients with AMD, who have decreased choroidal perfusion, may manifest more severely diminished choroidal ability to deliver oxygen and other metabolites to the retina, leading to growth of neovascular tissue. As a result of this engorgement of the choroidal vasculature, some patients may have leakage across the retinal pigment epithelium (RPE) and accumulation of subretinal fluid, resulting in CSC. Transient visual symptoms, i.e., changes in color perception and increased light sensitivity, are well-known adverse effects, but there have been rare reports of vision-threatening ocular complications in users of PDE5 inhibitors, such as nonarteritic anterior ischemic optic neuropathy and cilioretinal artery occlusion. The choroid is a vascular tissue analogous in many respects to the corpus cavernosum, and PDE5 inhibitors may increase the choroidal thickness and perfusion. While it is intuitively obvious that thickness of the choroid alone does not guarantee better choriocapillaris oxygenation, it is a reasonable step towards ameliorating ischemia. These drugs have numerous physiologic effects on the choroid related to blood flow, such as clinical consequences in CSC and AMD.
Effect of soil amendment with Chenopodium album dry biomass and two Trichoderma species on growth of chickpea var. Noor 2009 in Sclerotium rolfsii contaminated soil
Authors: Ali Amna , Javaid Arshad , Shoaib Amna , Khan Iqra Haider 
Published: August 2020

AbstractSclerotium rolfsii is a soil-borne plant pathogen that causes root diseases in hundreds of plant species. It also causes collar rot disease in chickpea (Cicer arietinum L.). The present pot study was carried out to investigate the effect of soil amendment with dry biomass of a weed Chenopodium album L. and two antagonistic fungi, namely Trichoderma harzianum and T. viride, on growth and yield of chickpea variety Noor 2009 in soil infected with S. rolfsii. The pathogen-contaminated soil was amended either with 1, 2, or 3% C. album dry biomass, T. harzianum, and T. viride alone, or combinations of either of the two Trichoderma species and plant dry biomass. The lowest shoot and root dry biomass and grain yield of chickpea were recorded in S. rolfsii inoculation alone without any soil amendment (positive control). Plant growth and yield were significantly and gradually increased over positive control with an increase in C. album dry biomass application in the soil. Likewise, soil application of either of the two Trichoderma species significantly enhanced plant growth and yield over positive control under biotic stress of S. rolfsii. Combined application of either T. harzianum or T. viride with 3% dry biomass of C. album also proved highly effective in alleviating biotic stress of S. rolfsii on growth and yield of chickpea.