bluuebunny/crossref_metadata_2025_split huggingface dataset:
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
Authors: Domingo-Rodriguez Laura , Ruiz de Azua Inigo , Dominguez Eduardo , Senabre Eric , Serra Irene , Kummer Sami , Navandar Mohit , Baddenhausen Sarah , Hofmann Clementine , Andero Raul , Gerber Susanne , Navarrete Marta , Dierssen Mara , Lutz Beat , Martín-García Elena , Maldonado Rafael 
Published: February 2020

AbstractFood addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemogenetic inhibition of neuronal activity in the mPFC-NAc pathway induces compulsive food seeking. Transcriptomic analysis and genetic manipulation identified that increased dopamine D2 receptor expression in the mPFC-NAc pathway promotes the addiction-like phenotype. Our study unravels a new neurobiological mechanism underlying resilience and vulnerability to the development of food addiction, which could pave the way towards novel and efficient interventions for this disorder.
Versatile cobalt-catalyzed regioselective chain-walking double hydroboration of 1,n-dienes to access gem-bis(boryl)alkanes
Authors: Hu Ming , Ge Shaozhong 
Published: February 2020

AbstractDouble hydroboration of dienes is the addition of a hydrogen and a boryl group to the two double bonds of a diene molecule and represents a straightforward and effective protocol to prepare synthetically versatile bis(boryl)alkanes, provided that this reaction occurs selectively. However, this reaction can potentially yield several isomeric organoboron products, and it still remains a challenge to control the regioselectivity of this reaction, which allows the selective production of a single organoboron product, in particular, for a broad scope of dienes. By employing a readily available cobalt catalyst, here we show that this double hydroboration yields synthetically useful gem-bis(boryl)alkanes with excellent regioselectivity. In addition, the scope of dienes for this reaction is broad and encompasses a wide range of conjugated and non-conjugated dienes. Furthermore, mechanistic studies indicate that this cobalt-catalyzed double hydroboration occurs through boryl-directed chain-walking hydroboration of alkenylboronates generated from anti-Markovnikov 1,2-hydroboration of 1,n-diene.
Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries
Authors: Bekker-Jensen Dorte B. , Bernhardt Oliver M. , Hogrebe Alexander , Martinez-Val Ana , Verbeke Lynn , Gandhi Tejas , Kelstrup Christian D. , Reiter Lukas , Olsen Jesper V. 
Published: February 2020

AbstractQuantitative phosphoproteomics has transformed investigations of cell signaling, but it remains challenging to scale the technology for high-throughput analyses. Here we report a rapid and reproducible approach to analyze hundreds of phosphoproteomes using data-independent acquisition (DIA) with an accurate site localization score incorporated into Spectronaut. DIA-based phosphoproteomics achieves an order of magnitude broader dynamic range, higher reproducibility of identification, and improved sensitivity and accuracy of quantification compared to state-of-the-art data-dependent acquisition (DDA)-based phosphoproteomics. Notably, direct DIA without the need of spectral libraries performs close to analyses using project-specific libraries, quantifying > 20,000 phosphopeptides in 15 min single-shot LC-MS analysis per condition. Adaptation of a 3D multiple regression model-based algorithm enables global determination of phosphorylation site stoichiometry in DIA. Scalability of the DIA approach is demonstrated by systematically analyzing the effects of thirty kinase inhibitors in context of epidermal growth factor (EGF) signaling showing that specific protein kinases mediate EGF-dependent phospho-regulation.
The place-cell representation of volumetric space in rats
Authors: Grieves Roddy M. , Jedidi-Ayoub Selim , Mishchanchuk Karyna , Liu Anyi , Renaudineau Sophie , Jeffery Kate J. 
Published: February 2020

AbstractPlace cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.
Finely tuned eye movements enhance visual acuity
Authors: Intoy Janis , Rucci Michele 
Published: February 2020

AbstractHigh visual acuity is essential for many tasks, from recognizing distant friends to driving a car. While much is known about how the eye’s optics and anatomy contribute to spatial resolution, possible influences from eye movements are rarely considered. Yet humans incessantly move their eyes, and it has long been suggested that oculomotor activity enhances fine pattern vision. Here we examine the role of eye movements in the most common assessment of visual acuity, the Snellen eye chart. By precisely localizing gaze and actively controlling retinal stimulation, we show that fixational behavior improves acuity by more than 0.15 logMAR, at least 2 lines of the Snellen chart. This improvement is achieved by adapting both microsaccades and ocular drifts to precisely position the image on the retina and adjust its motion. These findings show that humans finely tune their fixational eye movements so that they greatly contribute to normal visual acuity.
CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
Authors: Radhakrishnan Sabarinath V. , Luetkens Tim , Scherer Sandra D. , Davis Patricia , Vander Mause Erica R. , Olson Michael L. , Yousef Sara , Panse Jens , Abdiche Yasmina , Li K. David , Miles Rodney R. , Matsui William , Welm Alana L. , Atanackovic Djordje 
Published: February 2020

AbstractMultiple myeloma (MM) is a plasma cell malignancy and most patients eventually succumb to the disease. Chimeric antigen receptor (CAR) T cells targeting B-Cell Maturation Antigen (BCMA) on MM cells have shown high-response rates, but limited durability. CD229/LY9 is a cell surface receptor present on B and T lymphocytes that is universally and strongly expressed on MM plasma cells. Here, we develop CD229 CAR T cells that are highly active in vitro and in vivo against MM plasma cells, memory B cells, and MM-propagating cells. We do not observe fratricide during CD229 CAR T cell production, as CD229 is downregulated in T cells during activation. In addition, while CD229 CAR T cells target normal CD229high T cells, they spare functional CD229neg/low T cells. These findings indicate that CD229 CAR T cells may be an effective treatment for patients with MM.
Experimental neural network enhanced quantum tomography
Authors: Palmieri Adriano Macarone , Kovlakov Egor , Bianchi Federico , Yudin Dmitry , Straupe Stanislav , Biamonte Jacob D. , Kulik Sergei 
Published: February 2020

AbstractQuantum tomography is currently ubiquitous for testing any implementation of a quantum information processing device. Various sophisticated procedures for state and process reconstruction from measured data are well developed and benefit from precise knowledge of the model describing state-preparation-and-measurement (SPAM) apparatus. However, physical models suffer from intrinsic limitations as actual measurement operators and trial states cannot be known precisely. This scenario inevitably leads to SPAM errors degrading reconstruction performance. Here we develop a framework based on machine learning which generally applies to both the tomography and SPAM mitigation problem. We experimentally implement our method. We trained a supervised neural network to filter the experimental data and hence uncovered salient patterns that characterize the measurement probabilities for the original state and the ideal experimental apparatus free from SPAM errors. We compared the neural network state reconstruction protocol with a protocol treating SPAM errors by process tomography, as well as to an SPAM-agnostic protocol with idealized measurements. The average reconstruction fidelity is shown to be enhanced by 10% and 27%, respectively. The presented methods apply to the vast range of quantum experiments which rely on tomography.
Surface ruptures database related to the 26 December 2018, MW 4.9 Mt. Etna earthquake, southern Italy
Authors: Villani F. , Pucci S. , Azzaro R. , Civico R. , Cinti F. R. , Pizzimenti L. , Tarabusi G. , Branca S. , Brunori C. A. , Caciagli M. , Cantarero M. , Cucci L. , D’Amico S. , De Beni E. , De Martini P. M. , Mariucci M. T. , Messina A. , Montone P. , Nappi R. , Nave R. , Pantosti D. , Ricci T. , Sapia V. , Smedile A. , Vallone R. , Venuti A. 
Published: February 2020

AbstractWe provide a database of the surface ruptures produced by the 26 December 2018 Mw 4.9 earthquake that struck the eastern flank of Mt. Etna volcano in Sicily (southern Italy). Despite its relatively small magnitude, this shallow earthquake caused about 8 km of surface faulting, along the trace of the NNW-trending active Fiandaca Fault. Detailed field surveys have been performed in the epicentral area to map the ruptures and to characterize their kinematics. The surface ruptures show a dominant right-oblique sense of displacement with an average slip of about 0.09 m and a maximum value of 0.35 m. We have parsed and organized all observations in a concise database, with 932 homogeneous georeferenced records. The Fiandaca Fault is part of the complex active Timpe faults system affecting the eastern flank of Etna, and its seismic history indicates a prominent surface-faulting potential. Therefore, this database is essential for unravelling the seismotectonics of shallow earthquakes in volcanic areas, and contributes updating empirical scaling regressions that relate magnitude and extent of surface faulting.
Herbicide drift exposure leads to reduced herbicide sensitivity in Amaranthus spp.
Authors: Vieira Bruno C. , Luck Joe D. , Amundsen Keenan L. , Werle Rodrigo , Gaines Todd A. , Kruger Greg R. 
Published: February 2020

AbstractWhile the introduction of herbicide tolerant crops provided growers new options to manage weeds, the widespread adoption of these herbicides increased the risk for herbicide spray drift to surrounding vegetation. The impact of herbicide drift in sensitive crops is extensively investigated, whereas scarce information is available on the consequences of herbicide drift in non-target plants. Weeds are often abundant in field margins and ditches surrounding agricultural landscapes. Repeated herbicide drift exposure to weeds could be detrimental to long-term management as numerous weeds evolved herbicide resistance following recurrent-selection with low herbicide rates. The objective of this study was to evaluate if glyphosate, 2,4-D, and dicamba spray drift could select Amaranthus spp. biotypes with reduced herbicide sensitivity. Palmer amaranth and waterhemp populations were recurrently exposed to herbicide drift in a wind tunnel study over two generations. Seeds from survival plants were used for the subsequent rounds of herbicide drift exposure. Progenies were subjected to herbicide dose-response studies following drift selection. Herbicide drift exposure rapidly selected for Amaranthus spp. biotypes with reduced herbicide sensitivity over two generations. Weed management programs should consider strategies to mitigate near-field spray drift and suppress the establishment of resistance-prone weeds on field borders and ditches in agricultural landscapes.
High-precision polarimetry of nearby stars (d < 50 pc)
Authors: Piirola V. , Berdyugin A. , Frisch P. C. , Kagitani M. , Sakanoi T. , Berdyugina S. , Cole A. A. , Harlingten C. , Hill K. 
Published: February 2020

Context. We investigate the linear polarization produced by interstellar dust aligned by the magnetic field in the solar neighborhood (d < 50 pc). We also look for intrinsic effects from circumstellar processes, specifically in terms of polarization variability and wavelength dependence.
Aims. We aim to detect and map dust clouds which give rise to statistically significant amounts of polarization of the starlight passing through the cloud, and to determine the interstellar magnetic field direction from the position angle of the observed polarization.
Methods. High-precision broad-band (BV R) polarization observations are made of 361 stars in spectral classes F to G, with detection sensitivity at the level of or better than 10−5 (0.001%). The sample consists of 125 stars in the magnitude range 6–9 observed at the 2.2 m UH88 telescope on Mauna Kea, 205 stars in the magnitude range 3–6 observed at the Japanese (Tohoku) T60 telescope on Haleakala, and 31 stars in the magnitude range 4–7 observed at the 1.27 m H127 telescope of the Greenhill Observatory, Tasmania. Identical copies of the Dipol-2 polarimeter are used on these three sites.
Results. Statistically significant (>3σ) polarization is found in 115 stars, and >2σ detection in 178 stars, out of the total sample of 361 stars. Polarization maps based on these data show filament-like patterns of polarization position angles, which are related to both the heliosphere geometry, the kinematics of nearby clouds, and the Interstellar Boundary EXplorer ribbon magnetic field. From long-term multiple observations, a number (~20) of stars show evidence of intrinsic variability at the 10−5 level. This can be attributed to circumstellar effects (e.g., debris disks and chromospheric activity). The star HD 101805 shows a peculiar wavelength dependence, indicating size distribution of scattering particles different from that of a typical interstellar medium. Our high signal-to-noise measurements of nearby stars with very low polarization also provide a useful dataset for calibration purposes.
The sustainable built environment maintained by the Betawian traditional house’s faithfulness in local wisdom
Authors: Asriningpuri Handajani 
Published: February 2020

Abstract
The uniqueness of construction and building process influences the purpose of form, generally recognized by local wisdom. Occasionally climate will not influence the building it follows, custom-tradition and environment condition that determine the differences of characteristics in responding to the climate. There are three elements to consider in architectural discipline: Nature as a place that influences the building; Building as a product to fulfill human necessity to stay in nature, and human as user, occupant, designer or builder. Those elements are inseparable, as they link to each other. Consequently it is important to take into account the environmental conditions when establish building and dwelling. Beside that it is necessary for house residents to obey and follow the stipulation regulated by local custom or tradition. The Betawian house is traditional house that maintains the built environment sustainability it is faithfulness in the local wisdom. For instance the house has veranda as a respond to the climate. For that reasons the author conducted this research with the following hypothesis “the fidelity to local wisdom in supporting the traditional house’s response to the climate” with descriptive-qualitative methodology. The discussion included the theory of traditional architecture in Indonesia, the Betawian ethnic house; the tropical architecture-building theory and the sustainable architecture theory. Findings showed the decrease a number of housing and dwelling that use of local wisdom as a response to the climate changes. One of the research goals was to preserve the local wisdom by maintaining the traditional house and teaching the house resident to preserve. Publishing a journal article is a way to raise the awareness of the built environment sustainability.
Rights to the city, tolerance, and the Javanese concepts of “Rukun” and “Tepo Sliro”: a portray from five kampungs in Yogyakarta
Authors: Setiawan Bakti 
Published: February 2020

Abstract
The research explores how the notion of ‘rights to the city,’ as an important element of the contestation over the globalized “human rights’ movement, is then manifested and implemented in local context. It aims to understand whether the idea of rights to the city is perceived and practiced in a specific setting, the urban Javanese context and setting, in this case, the historic city of Yogyakarta. It is based on the idea that in historic city like Yogyakarta, existing local norms and concepts could be contested with western norms and concepts of rights to the city. This was an exploratory research, utilizing multiple case studies approach and method to understand local norms and theories related to the issue of rights to the city and city tolerance. The research purposively selected five case studies that represented the Javanese concepts of rights to the city and city tolerance. It revealed that the practice of Javanese concepts of ‘rukun’ and ‘tepo sliro’ could be contested with the western concepts of rights to the city and city tolerance. It, however, also showed that such concepts were not free from misuse and even abuse to maintain status quo or to exhibit quasi-harmony. The paper also showed how the idea of inclusive and sustainable city under the New Urban Agenda was interpreted and implemented in local situation and contexts.
Air temperature and CO2 concentration in naturally ventilated classrooms in hot and humid tropical climate
Authors: Talarosha Basaria , Satwiko Prasasto , Aulia Dwira Nirfalini 
Published: February 2020

Abstract
Students at the public primary schools in Medan city, Indonesia, complete 90% of their learning activities in the same classroom, which, in order to save energy, utilises natural ventilation to obtain thermal comfort and fresh air for indoor air quality, which is the physical school environment that impacts the students’ achievement. Air temperature is a crucial factor that influences thermal comfort, while the CO2 concentration determines the quality of fresh air. This paper aims to describe air temperature and the CO2 concentration in an occupied naturally cross-ventilated classroom in a hot and humid tropical climate, in Medan city, Indonesia. The air temperature and CO2 level were simultaneously monitored for four days during the students’ lesson hours in a school classroom that complies with the regulations of the Ministry of Education of Indonesia about the infrastructure standards for elementary, junior high, and senior high schools. The results of this study showed that air temperature in the classroom exceeded the comfortable temperature, while the median CO2 concentration was below 1000 ppm as recommended by ASHRAE and WHO.
An overview of durability model for timber structure decay under Indonesian climate
Authors: Prabowo Herry , Hilmy Mochamad 
Published: February 2020

Abstract
The problem of wood durability is closely related to the degradation mechanism that can be distinguished into mechanical, physical, biological, and chemical degradation. The most affecting combination of degradation in modelling the durability of wood structures is a combination of mechanical and biological. The durability model of wood structure reviewed was based on a model developed by CSIRO (Commonwealth Scientific and Industrial Research Organization), Australia. Parameters taken into account in the model included physical wood, climate, coating paint, thickness, width, connection, and geometry parameters. The model predicted a decay rate for timber installed in-ground and timber above-ground. The results of this study were expected to provide a preliminary description of the behavior of the durability of wood structures based on several parameters adapted based on environmental conditions in Indonesia.
Adaptive thermal comfort of naturally ventilated classrooms of elementary schools in the tropics
Authors: Hamzah Baharuddin , Mulyadi Rosady , Amin Samsuddin , Kusno Asniawaty 
Published: February 2020

Abstract
Thermal comfort is one of the very important factors in enhancing the human quality of life, including students who spend a lot of times learning in schools. This article was intended to analyze the students’ adaptive thermal comfort in naturally ventilated classrooms of the elementary schools in the tropical city of Makassar. The study analyzed data gathered from 33 surveyed classrooms in six primary schools. The recorded data consisted of the personal and adaptive behavior of 1,111 students, and the thermal environments of the classrooms. At the same time, students filled out the questionnaires asking their thermal sensation, comfort level, and thermal preferences against the classrooms’ thermal environments. The results of measurements showed that the indoor mean air temperature, air humidity, and air velocity were 30.4 °C, 68%, and 0.1 m/s, respectively. They indicated that the classrooms had the hot temperature, high humidity, and low air velocity. The calculated PMV based on these parameters showed that about 90% of students felt either warm (+2) or hot (+3). The PMV overestimated the actual students’ thermal comfort where more than 85% of students voted slightly cool (-1), neutral (0), and slightly warm (+1). In addition, the neutral temperature predicted by PMV was 25.5 °C. This neutral temperature was very low in comparison to 30.2 °C calculated by using thermal sensation vote (TSV). These suggested that students of elementary schools in the tropic were tolerant to the hot environment. The use of the adaptive models to calculate the neutral temperature of students presented similar results gathered from actual votes. Therefore, the adaptive model became the best method to explain the thermal comfort of students in the elementary schools in the tropics.