bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis on the Change Trend and Influencing Factors of Meteorological Drought in Huaihe River Basin
Authors: Qiang Zhao , Ran PengYu , Li XiFeng 
Published: December 2020

Abstract
Since the 21st century, the global warming trend has attracted the attention of the general public. Global temperature changes have caused many extremely severe weather events. This paper uses the meteorological data of 20 stations in the Huai River Basin from 1960 to 2017, combined with the historical records of meteorological disasters, and uses the SPI index to analyze the temporal and spatial distribution of meteorological drought. The conclusions are as follows: (1) SPI has a 14a main cycle and 4a, 5a, 6a, 11-12a and 22-24a secondary cycles. (2) The evolution characteristics of SPI show that the annual scale, spring, autumn, and winter increase at different speeds, and decrease in summer.
Numerical assessment of blade deflection and elongation for improved monitoring of blade and TBC damage
Authors: Van Dyke Jason , Nganbe Michel 
Published: December 2020

Abstract
The reliability of turbine blades is largely maintained by damage tolerance approach based on monitoring and pre-set periodic inspections. This can result in unnecessary downtimes, premature part retirement and unforeseeable failures. Therefore, there is growing interest in systems that can reliably detect damages in real‐time. However, many current sensors are based on blade tip clearance and time of arrival. The first primarily correlates with relatively predictable long-term creep deformation and ensuing blade elongation, while the second can be related to blade deflection. Therefore, this research comparatively assesses the two parameters. For this purpose, TBC defects, representative for coating spallation, and notches, representative for blunted blade cracks, are investigated. Overall, the results suggest that the measurement of changes in axial deflection could show higher sensitivity to cracks and TBC defects, and therefore, constitutes a potential alternative for continuous monitoring with respect to unforeseeable rapidly growing blade damage. Moreover, TBC spallation seems more difficult to immediately detect as the ensuing changes in blade tip position are small. However, they cause changes in deflection that can switch from negative to positive as they are located closer to the blade root, which may allow to assess their location during monitoring. In contrast, critical cracks located close to the blade root can cause measurable changes in blade deflexion, potentially making their timely detection and continuous monitoring possible.
Intestinal crypt-derived enteroid coculture in presence of peristaltic longitudinal muscle myenteric plexus
Authors: Levin Daniel E , Mandal Arabinda , Fleming Mark A , Bae Katherine H , Gerry Brielle , Moore Sean R 
Published: December 2020

Abstract
The role of enteric neurons in driving intestinal peristalsis has been known for over a century. However, in recent decades, scientists have begun to unravel additional complex interactions between this nerve plexus and other cell populations in the intestine. Investigations into these potential interactions are complicated by a paucity of tractable models of these cellular relationships. Here, we describe a novel technique for ex vivo coculture of enteroids, so called “mini-guts,” in juxtaposition to the longitudinal muscle myenteric plexus (LMMP). Key to this system, we developed a LMMP culture media that: (i) allows the LMMP to maintain ex vivo peristalsis for 2 weeks along with proliferation of neurons, glia, smooth muscle and fibroblast cells, and (ii) supports the proliferation and differentiation of the intestinal stem cells into enteroids complete with epithelial enterocytes, Paneth cells, goblet cells, and enteroendocrine cells. Importantly, this technique identifies a culture condition that supports both the metabolic needs of intestinal epithelium as well as neuronal elements, demonstrating the feasibility of maintaining these two populations in a single culture system. This sets the stage for experiments to better define the regulatory interactions of these two important intestinal cell populations.
Cerebral embolism due to left atrial myxoma in a patient presenting with chest pain and ST-segment elevation: a case report
Authors: Fontes António , Dias-Ferreira Nuno , Tavares Anabela , Neves Fátima 
Published: December 2020

Abstract

Background
Myocarditis is an uncommon, potentially life-threatening disease that presents with a wide range of symptoms. In acute myocarditis, chest pain (CP) may mimic typical angina and also be associated with electrocardiographic changes, including an elevation of the ST-segment. A large percentage (20–56%) of myxomas are found incidentally.

Case summary
A 62-year-old female presenting with sudden onset CP and infero-lateral ST-elevation in the electrocardiogram. The diagnosis of ST-elevation myocardial infarction was presumed and administered tenecteplase. The patient was immediately transported to a percutaneous coronary intervention centre. She complained of intermittent diplopia during transport and referred constitutional symptoms for the past 2 weeks. Coronary angiography showed normal arteries. The echocardiogram revealed moderate to severe left ventricular systolic dysfunction due to large areas of akinesia sparing most of the basal segments, and a mobile mass inside the left atrium attached to the septum. The cardiac magnetic resonance (CMR) suggested the diagnosis of myocarditis with concomitant left atrial myxoma. The patient underwent resection of the myxoma. Neurological evaluation was performed due to mild vertigo while walking and diplopia in extreme eye movements. The head magnetic resonance imaging identified multiple infracentimetric lesions throughout the cerebral parenchyma compatible with an embolization process caused by fragments of the tumour.

Discussion
Myocarditis can have various presentations may mimic acute myocardial infarction and CMR is critical to establish the diagnosis. Myxoma with embolic complications requires emergent surgery. To the best of our knowledge, this is the first case reported in the applicable literature of a myxoma diagnosed during a myocarditis episode.
Ribosomal RNA 2′O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer
Authors: Marcel Virginie , Kielbassa Janice , Marchand Virginie , Natchiar Kundhavai S , Paraqindes Hermes , Nguyen Van Long Flora , Ayadi Lilia , Bourguignon-Igel Valérie , Lo Monaco Piero , Monchiet Déborah , Scott Véronique , Tonon Laurie , Bray Susan E , Diot Alexandra , Jordan Lee B , Thompson Alastair M , Bourdon Jean-Christophe , Dubois Thierry , André Fabrice , Catez Frédéric , Puisieux Alain , Motorin Yuri , Klaholz Bruno P , Viari Alain , Diaz Jean-Jacques 
Published: December 2020

AbstractRecent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′O-methylation is an additional layer of gene expression regulation highlighting the ribosome as a novel actor of translation control. However, this major finding lies on evidences coming mainly, if not exclusively, from cellular models. Using the innovative next-generation RiboMeth-seq technology, we established the first rRNA 2′O-methylation landscape in 195 primary human breast tumours. We uncovered the existence of compulsory/stable sites, which show limited inter-patient variability in their 2′O-methylation level, which map on functionally important sites of the human ribosome structure and which are surrounded by variable sites found from the second nucleotide layers. Our data demonstrate that some positions within the rRNA molecules can tolerate absence of 2′O-methylation in tumoral and healthy tissues. We also reveal that rRNA 2′O-methylation exhibits intra- and inter-patient variability in breast tumours. Its level is indeed differentially associated with breast cancer subtype and tumour grade. Altogether, our rRNA 2′O-methylation profiling of a large-scale human sample collection provides the first compelling evidence that ribosome variability occurs in humans and suggests that rRNA 2′O-methylation might represent a relevant element of tumour biology useful in clinic. This novel variability at molecular level offers an additional layer to capture the cancer heterogeneity and associates with specific features of tumour biology thus offering a novel targetable molecular signature in cancer.
Short-term impact of surgically induced menopause on cognitive function and wellbeing in women at high risk for ovarian cancer following risk-reducing bilateral salpingo-oophorectomy
Authors: Chang Heidi , Kamara Daniella , Bresee Catherine , Lester Jenny , Cass Ilana 
Published: December 2020

Abstract

Objective:
Risk-reducing bilateral salpingo-oophorectomy (RRSO) is an effective strategy to prevent pelvic serous carcinoma for women at high risk of developing ovarian cancer; however, it results in premature menopause. Data is lacking to adequately counsel these women about potential effects of premature menopause on cognition and quality of life.

Methods:
A prospective study in premenopausal women at high risk of ovarian cancer to determine changes in cognition over time after RRSO and the impact of hormone therapy (HT) on cognition. Participants were surveyed before and after surgery using the Functional Assessment of Cancer Therapy-Cognitive questionnaire and questions regarding domains of wellbeing at 6, 12 and 18 months. Data was tested for changes across time using mixed model regression and logistic regression.

Results:
Fifty-seven women were included. Sixty-three percent of participants used HT. At 6 months postoperatively, perceived cognitive impairment declined by 5.5 points overall (4.4 in non-HT users and 6 in HT users), P = 0.003. The other domains of cognition assessed did not change significantly over time and the use of HT did not impact scores. Sleep disruption was common in this cohort and was not mitigated by HT. Self-reported depression improved after RRSO (P = 0.004).

Conclusion:
Women at high risk of ovarian cancer who choose RRSO may experience declines in cognition within the first 6 months of surgical menopause. HT may cause small declines in perceived cognitive impairment at 6 months after RRSO. Women can expect more sleep disruption after menopause, which is not mitigated by HT.

Video Summary:
http://links.lww.com/MENO/A697.
Endovascular management of symptomatic stenosis of supra-aortic arteries in patients with Takayasu arteritis
Authors: Chen Shu-Ting , Luo Chao-Bao , Guo Wan-Yuo , Chang Feng-Chi 
Published: December 2020

Background:
Endovascular management is used to treat Takayasu arteritis (TA) involving the supra-aortic branches. However, the long-term outcome of this treatment remains unclear. Here, technical safety, outcomes, and restenosis management of supra-aortic arteries in TA patients receiving endovascular treatment were evaluated.

Methods:
TA patients with symptomatic supra-aortic stenosis who underwent percutaneous angioplasty and stenting between 2008 and 2018 at our institute were enrolled in this study. Pre- and post-procedural magnetic resonance imaging (MRI) evaluations, including high-resolution vessel wall imaging (HR-VWI), were performed. Technical efficacy, peri-procedural complications, early post-procedural MRI results, and stent patency were examined.

Results:
All six patients successfully received stent placement or percutaneous transluminal angioplasty in a total of 22 treated arteries without neurologic complications. During follow-up (mean, 56.3 ± 41.1 months), no recurrent stroke occurred, yet significant restenosis developed in 12 of 22 (54.5%) of the treated arteries. Three of the patients underwent HR-VWI before surgery. Concentric wall thickening and enhancement of the left common carotid artery was detected in one patient, indicating acute inflammation. Angioplasty with drug-eluting balloon (DEB) successfully treated a case of refractory restenosis. Among 10 early post-procedure MRI performed, only two asymptomatic new lesions were detected with diffusion-weighted imaging.

Conclusion:
Endovascular treatment of supra-aortic arteries of TA patients was safe and effective, yet was associated with a high restenosis rate. Thus, close follow-up is needed. HR-VWI is helpful for pre-procedural selection of patients for percutaneous angioplasty and stenting and drug-eluting balloon angioplasty appears to be a promising treatment for refractory in-stent restenosis.
A Qualitative Study of the Health-Related Perceptions of Married Iranian Women Who Have Experienced Domestic Violence
Authors: Rezaee Nasrin , Mardani-Hamooleh Marjan 
Published: December 2020

ABSTRACT

Introduction
Violence against women occurs all over the world; it is a phenomenon that is considered an invasion of human rights. The most common form of this phenomenon is domestic violence (DV).

Aim
The purpose of this study was to explore the health-related perceptions of married women in Iran who have experienced DV.

Method
This qualitative study was carried out using conventional content analysis method. In total, a purposive sample of 27 women who had been subjected to violence by their spouses agreed to participate in this study. Individual, in-depth, and semistructured interviews were conducted.

Findings
Three main categories emerged from the data: (a) perceptions related to physical health (including non-sex-organ injuries and sex organ injuries), (b) perceptions related to psychological health (including fear, concern, and the creation of challenges), and (c) perceptions related to sociocultural health (specifically social health and cultural health).

Conclusion
In Iran, DV threatens women's health and is influenced by personal, familial, social, and cultural factors. Nurses should consider various aspects of physical, psychological, and sociocultural health when caring for women who have experienced DV. Social and cultural-based interventions are needed to address negative attitudes, stigma, and false beliefs that sanction DV in Iran.
Increased Radiosurgery Toxicity Associated With Treatment of Vestibular Schwannoma in Multiple Sclerosis
Authors: Wallerius Katherine , Collins Sean , Forsthoefel Matthew , Kim Hung Jeffrey 
Published: December 2020

Objective:
Explore the risk of radiation-induced neurotoxicity in patients with multiple sclerosis (MS) treated with stereotactic radiosurgery (SRS) and better understand the pathophysiology of radiation-induced injury in the central nervous system (CNS).

Patients/Intervention:
We present the clinical course and magnetic resonance imaging (MRI) findings of a 52-year-old woman with a history of relapsing remitting MS, who developed radiation-induced neurotoxicity following CyberKnife SRS (25 Gy in five fractions) for a left-sided vestibular schwannoma (VS).

Main Outcome Measure:
Risk of radiation-induced damage following SRS to the CNS, including radiation type and dose, toxicity, and time to symptom onset, in patients with MS.

Results:
Our patient developed increased imbalance (grade 2 toxicity) 3 months following CyberKnife SRS. Brain MRI showed new fluid-attenuated inversion recovery (FLAIR) hyperintensity in the pons and cerebellum. Neurotoxicity from SRS is rare. However, our literature review showed that 19 patients with MS who underwent intracranial radiation therapy sustained radiation-induced toxicity. The potential mechanisms for increased toxicity in MS could be due to a combination of demyelination, inflammatory, and/or vascular changes. Efficacy of treatments including steroids, bevacizumab, and hyperbaric oxygen therapy is currently unknown.

Conclusion:
Treatment options of SRS and surgery for VS should be carefully considered as patients with known MS may be at increased risk for radiation-induced damage following SRS to the CNS. Thoughtful radiosurgical planning and dosing accounting for this inherent risk is essential for managing patients with MS and VS.
Treatment Analysis and Overall Survival Outcomes of Patients With Bilateral Vestibular Schwannoma
Authors: Goshtasbi Khodayar , Abouzari Mehdi , Yasaka Tyler M. , Soltanzadeh-Zarandi Sina , Sarna Brooke , Lin Harrison W. , Djalilian Hamid R. 
Published: December 2020

Objectives:
To investigate the clinical presentation, treatment breakdown, and overall survival (OS) outcomes of patients with neurofibromatosis type 2 (NF2)-associated bilateral vestibular schwannoma (NVS).

Methods:
The 2004 to 2016 National Cancer Database was queried for patients with a diagnosis of VS. The “Laterality” code was used to stratify patients into sporadic unilateral vestibular schwannoma (UVS) and NVS.

Results:
Of the 33,839 patients with VS, 155 (0.46%) were coded for NVS with an average age and tumor size of 37.4 ± 20.5 years and 23.5 ± 18.2 mm. Patients underwent observation (45.3%), surgery (29.3%), and radiotherapy (20.0%), and had a 5.8% 5-year mortality rate. Compared with UVS, NVS was negatively associated with receiving surgery (40.2% versus 29.3%, p = 0.02) while watchful observation was more prevalent (30.1% versus 45.3%, p = 0.001). In NVS, undergoing surgery was associated with larger tumor size (34.5 ± 21.2 versus 17.8 ± 13.3 mm, p = 0.001) and shorter diagnosis-to-treatment time (49.1 ± 60.6 versus 87.0 ± 78.5 d, p = 0.02), radiotherapy was associated with older age (44.4 ± 18.9 versus 35.2 ± 20.6 yr, p = 0.02) and longer diagnosis-to-treatment time (85.9 ± 77.9 versus 53.9 ± 65.5 d, p = 0.04), and observation was associated with smaller tumor size (17.8 ± 15.9 versus 28.0 ± 19.2 mm, p = 0.01). Kaplan–Meier log-rank analysis demonstrated similar 10-year OS between NVS and UVS patients (p = 0.58) without factoring the earlier age of presentation. Furthermore, there were no temporal changes in presentation/management of NVS, and OS was not dependent on the received treatment (p = 0.30).

Conclusions:
With younger age, larger tumors, and more conservative management, NVS's OS was not treatment-dependent and was similar to sporadic UVS, though the latter should not be interpreted as similar life expectancies due to the much earlier presentation.
Balloon Dilation for Obstructive Eustachian Tube Dysfunction in Children
Authors: Toivonen Joonas , Kawai Kosuke , Gurberg Joshua , Poe Dennis 
Published: December 2020

Objective:
Determine the safety and efficacy of balloon dilation of the Eustachian tube (ET) in pediatric patients.

Study Design:
Retrospective matched cohort study.

Setting:
Tertiary medical center.

Patients:
Pediatric patients (<18 yr) with persistent (>1.5 yr) chronic Eustachian tube dysfunction (ETD) with previous tympanostomy tube (TT) insertion versus matched controls.

Intervention(s):
Balloon dilation of the cartilaginous ET (BDET) was performed using concomitant myringotomy with/without tube placement and adjunctive procedures if indicated versus controls (TT).

Main Outcome Measure(s):
Otitis media with effusion (OME)/retraction with need for additional tube, tympanogram, audiogram, otomicroscopy, ET mucosal inflammation/opening score, and Valsalva maneuver.

Results:
Forty six ETs (26 patients), ages 7 to 17 years (mean 12.5) underwent BDET. Mean follow-up was 2.3 years (standard deviation [SD], 1.1; range, 6 mo–5 yr). Significant improvements were observed for all measures. Tympanic membranes were healthy in 9% preoperatively, 38% at 6 months, 55% at 12 months, and 93% at 36 months postoperatively. Tympanograms improved to type A in 50% at 6 months, 59% at 12 months, and 85% at 36 months. Mean scores of mucosal inflammation declined from 3.2 (±0.6) preoperatively to 2.5 (±0.7) at 6 months and 1.7 (±0.6) at 36 months postoperatively. BDET had lower risk of failure versus TT insertion (adjusted hazard ratio [HR] 0.26; 95% confidence interval [CI]: 0.10, 0.70; p = 0.007). Probability of being failure free at 2 years was 87% (95% CI: 70, 94%) after BDET and 56% (95% CI: 40, 70%) after TT insertions.

Conclusions:
BDET is a safe and possibly effective procedure in selected pediatric patients with chronic ETD.
Quantitative Differentiation of Left Atrial Performance in Hypertrophic Cardiomyopathy
Authors: Ran Hong , Schneider Matthias , Wan Lin-lin , Ren Jun-yi , Ma Xiao-wu , Zhang Ping-yang 
Published: December 2020

Objective:
The objective of this study was to describe the different components of left atrial (LA) dysfunction predictors in nonobstructive and occult obstructive hypertrophy cardiomyopathy (HCM) patients especially with preserved left ventricular (LV) ejection fraction, particularly using LA 4-dimensional (D) longitudinal and circumferential strains.

Methods:
Twenty-eight nonobstructive HCM patients and 30 occult obstructive HCM patients according to LV outflow tract gradient at rest and after exercise were prospectively enrolled. 4D echocardiographic evaluation was performed in 58 HCM patients, both nonobstructive and occult obstructive, and 38 control subjects. LA reservoir, conduit, contractile functions were performed by 4D volume-strain with volumes and longitudinal, circumferential strains.

Results:
Optimal correlation coefficients obtained between LV 4D mass (index) and LA 4D longitudinal/circumferential strain (r=−0.860 to 0.518, all P<0.001). Both nonobstructive and occult obstructive HCM patients had increased volumes and significantly decreased longitudinal, circumferential strain values with lower reservoir, conduit, contractile functions than the controls (all P<0.001). Occult obstructive HCM patients presented incremented volumes compared with nonobstructive ones (P<0.001 to 0.003). Lower conduit function and higher contractile function indicated with lower reservoir function revealed by circumferential strain in occult obstructive HCM patients than nonobstructive ones (P<0.001 to 0.017). Interclass correlation coefficients of intraobserver and interobserver in the LV and LA 4D value evaluations were >0.75 and >0.85, respectively.

Conclusions:
LA volumes were significantly increased and LA reservoir, conduit, and contractile functions were significantly impaired in HCM patients. Furthermore, different performances of LA functional analyses in nonobstruction and occult obstruction patients with 4D volume-strain echocardiography may facilitate the recognition of subtle LA dysfunctional differentiation in HCM patients.