bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotics use and gentamicin residues in commercial poultry and chicken eggs from Oyo and Lagos States, Nigeria
Authors: Olatoye Olufemi I. , Ojomo Tope O. , Adeseko Yomi J. 
Published: November 2019

Nigeria poultry industry is fast growing to meet the demand of the increasing population with overdependence on antibiotics for production leading to consumer safety and public health concerns. The antibiotic use in poultry farms and presence of gentamicin residues in chicken eggs from city markets of Southwest Nigeria were investigated. A semi-structured questionnaire was administered to 45 poultry farmers to determine the patterns of antibiotic use, knowledge of withdrawal periods and food safety implications. Furthermore, 270 egg samples from six retail markets in Oyo and Lagos states were analyzed with ELISA for gentamicin residues. Residue concentrations were compared with Student’s t test and ANOVA (p < 0.05). About 90% of the respondents reported they frequently administered antibiotics, 85% engaged in non-prescribed medication, and about 80% did not observe a withdrawal period before selling the eggs from treated chickens. In addition, 60% and 80% of pooled eggs from Oyo and Lagos states, respectively, contained gentamicin residues with means of 1461 ± 74 and 1350 ± 92 µg/kg, respectively. The mean residues obtained from the two states were higher than the maximum recommended residue limits. High levels of gentamicin residues, from unbridled use of antibiotics in poultry production, detected in retail eggs from markets rendered the eggs unsafe for human consumption. Therefore, regulatory control and veterinary supervision of antibiotic use are advocated to ensure Nigerian consumer protection.
O vazio e o movimento
Authors: Gil Ana Godinho 
Published: November 2019

Numa dobra entre a filosofia e as artes em geral surge um espaço de experimentação singular e dele surge uma multiplicidade de problemáticas. Respira-se e vive-se intensamente nele. O pensamento e as sensações podem constituir linhas de fuga que atravessam esse espaço – vazio – e nos permitem sobrevoar ou mergulhar em tudo o que escapa. Desencadeiam-se movimentos, procurando operações reais que vão muito para lá do dizível e do pensável, e que nos interessam estudar. O vazio será então “o lugar funcional”, meio de transporte e de captura das forças. Dele e do ritmo ligados entre si sai o sopro, é o sopro que exige o vazio, é o sopro que exige um outro corpo, porque é ele que une todas as coisas. O sopro é então o lugar comum, potência imperceptível, entre o indivíduo e o universo.
Pencapaian Kompetensi Mahasiswa Prodi D4 Kebidanan pada Mata Kuliah Asuhan Kehamilan Dengan Metode Pembelajaran Laboratorium Klinik di Laboratorium Ante Natal Care STIKES Karya Husada Kediri
Authors: Asiyah Siti 
Published: November 2019

Metode Pembelajaran laboratorium klinik adalah melatih mahasiswa untuk berinteraksi langsung dengan ibu hamil dengan pendampingan lansung oleh dosen ( badside teaching ). Tujuan Penelitian ini adalah menganalisa peningkatan kompetensi mahasiswa semester 2 Prodi D4 kebidanan setelah diterapkan metode pembelajaran laboratorium Klinik. Jenis Penelitian adalah penelitian Tindak Kelas Desain penelitian yang digunakan adalah Quassy experiment dengan pendekatan one group pre test- post test. Variabel indipendent metode laboratorium klinik, variabel dependent kompetensi mahasiswa pada mata kuliah Asuhan Kehamilan. Populasi adalah seluruh mahasiswa di Prodi D4 Kebidanan berjumlah 97 mahasiswa , tehnik sampling dengan proporsif sampling sampel penelitian berjumlah 29 mahasiswa . Instrumen penelitian test subjektif dan cek list unjuk kerja. Penelitian dilaksanakan 29 Mei -29 Juli 2017 bertempat di Laboratorium Ante Natal Care STIKES Karya Husada, analisa data dengan uji wilcoxon. Hasil penelitian dari 29 mahasiswa didapatkan kopetensi dalam asuhan kehamilan setelah laboratorium dengan panhon terbanyak nilai BC 9 orang (31%) . Kompetensi dalam asuhan kehamilan setelah laboratorium klinik terbanyak nilai A 26 orang (89.7%). Hasil analisis uji beda dengan Wilcoxon Signed Ranks Test didapatkan hasil nilai Z hitung = -4,649 dengan p value 0,000 > a 0,05 berarti ada perbedaan kompetensi mahasiswa semester 2 Prodi D4 Kebidanan antara sebelum dilaksanakan dengan setelah dilaksanakan bimbingan laboratorium klinik Asuhan Kehamilan. Metode pembelajaran laboratorium klinik atau bedside teaching ini masih jarang digunakan meskipun dari penelitian ini juga membuktikan cukup efektif untuk meningkatkan kompetensi mahasiwa dalam Asuhan Kehamilan.
Pengaruh Susu Kedelai terhadap Ekspresi Reseptor Estrogen-Β Uterus pada Masa Reproduksi Awal Rattus Norvegicus Betina
Authors: Dinastiti Vide Bahtera , Nurdiana Nurdiana , Dwijayasa Pande Made 
Published: November 2019

Receptors estrogen can also stimulated by other, namely by fitoestrogen. Fitoestrogen are the group of non steroid plants that have composition resembling the natural estrogen in the body. One of it is isoflavon, that can be binding with receptor estrogen, which affinity for RE-β is greater than RE-α and can make potential effect because receptors estrogen will blocked by isoflavon and cannot be occupied by estrogen.This compound can harm the endocrine system of the body because of the possible bad effects for reproductive function. Isoflavonoid is mostly found in soy. Soybean can be processed to soybean milk. The purpose of this study is demonstrate that administration of soy milk can affect the expression of RE-β uterus at the early reproductive period of female Rattus norvegicus. The method used is an experimental design post test control group design. The sample in this study is 24 Rattus norvegicus females. Then divided into four groups: one control group and three treatment groups were given soy milk each dose of 2.5 mg/kg/weight; 5mg/kg/weight; 10mg/kg/weight. The expression of RE-β uterus were measured by immunohistochemistry. Based on the analysis using ANOVA, was obtained p-value of 0.000, smaller than α = 0:05 (p <0.05). There is a significant influence on the administration of soy milk increase expression of RE-β and by LSD test obtained the results of differences from application of soy milk with different doses.
Toxicity of Povidone-Iodine to the Ocular Surface of Rabbits
Authors: Kim Sun Young , Ahn Yong Sun , Lee Yeo Jin , Kim Hyun Seung 
Published: November 2019

Abstract
Background: We evaluated the toxicity of 5% (w/v) povidone-iodine (PI) applied to the ocular surface of rabbits.
Methods: Twenty-three white rabbits were divided into four groups; these were a control group and three study groups in which the ocular surface was exposed to PI for different times. In control group, one drop of phosphate-buffered saline (PBS) was applied once for 10 minutes. In study groups, one drop of 5% (w/v) PI was topically applied once for 1 minute, 3 minutes, and 10 minutes, and then the animals were observed for 7 days. The Schirmer test, Rose Bengal staining, corneal fluorescein staining and conjunctival impression cytology were performed on day 0, 3, and 7. After 7 days, the rabbits were sacrificed and conjunctiva and cornea were collected and evaluated by light and electron microscope. Immunofluorescence staining was also performed to detect mucin 5 subtype AC (MUC5AC).
Results: The decrease in goblet cell density, reductions in MUC5AC level and histopathological and ultrastructural changes of conjunctiva and cornea were more prominent in the 5% (w/v) PI groups than the control group (p < 0.05). Moreover, these changes were more prominent when PI was applied for 3 and 10 minutes rather than 1 minute (both p values < 0.05).
Conclusions: 5% (w/v) povidone-iodine caused damages to the ocular surface in a time-dependent manner. Therefore, we should be aware of that excessive PI exposure during ophthalmic procedures could be a pathogenic factor of dry eye syndrome after surgery.
The effects of occupational pollutants on the reproductive health of female informal street traders in Warwick Junction, Durban, South Africa – a cross-sectional study
Authors: Hariparsad Sujatha , Naidoo Rajen 
Published: November 2019

Abstract
Background: Informal street traders are exposed on a daily basis to traffic emissions and biomass fuel smoke containing a variety of pollutants. These exposures are likely to place the female traders at increased risk for adverse reproductive outcomes. Aim The aim of this study was to compare the reproductive outcomes among street traders exposed to pollutants from their work-related activities and traders without such exposure. Methods: A cross-sectional study was conducted among 305 female traders selected from exposed and non-exposed areas within the Warwick Junction trading hub, located in Durban, South Africa. Validated reproductive questionnaires and clinical assessments were conducted on all participants. Adverse reproductive outcomes such as low birth weight, spontaneous abortions and infertility were assessed Results: The mean age of the traders was 43.6 years (SD:12.1), mostly single (63%) and worked in trading hub for an average of 14 years. There were 876 pregnancies reported in the total sample. Traders pregnant while working in in this location accounted for 120 pregnancies There was an increased risk of exposed traders having a low birth weight infant as compared to non-exposed traders (OR=3.7; CI: 1.8, 7.6). Exposed traders were also almost 3 times more likely to be infertile as compared to non-exposed traders (OR=2.6; CI: 1.6, 4.3). Conclusions: Working as a street trader may have a causal association with developing adverse reproductive outcomes in females. Recommendations to mitigate adverse exposures have been suggested which include short term safety interventions and better cooking practices and future long term policy interventions.
Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)
Authors: Hu Wenjing , Gao Derong , Wu Hongya , Liu Jian , Zhang Chunmei , Wang Junchan , Jiang Zhengning , Liu Yeyu , Li Dongsheng , Zhang Yong , Lu Chengbin 
Published: November 2019

Abstract
Background: Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a major threat to wheat production and food security worldwide. Breeding stably and durably resistant cultivars is the most effective approach for managing and controlling the disease. The success of FHB resistance breeding relies on identification of an effective resistant germplasm. We performed a genome-wide association study (GWAS) using the high-density wheat 90K single nucleotide polymorphism (SNP) assays to better understand the genetic basis of FHB resistance in natural population and identify associated molecular markers.
Results: The resistance to FHB fungal spread along the rachis (Type II resistance) was evaluated on 171 wheat cultivars in the 2016-2017 (abbr. as 2017) and 2017-2018 (abbr. as 2018) growing seasons. Using Illumina Infinum iSelect 90K SNP genotyping data, a genome-wide association study (GWAS) identified 26 loci (88 marker-trait associations), which explained 6.65-14.18% of the phenotypic variances. The associated loci distributed across all chromosomes except 2D, 6A, 6D and 7D, with those on chromosomes 1B, 4A, 5D and 7A being detected in both years. New loci for Type II resistance were found on syntenic genomic regions of chromsome 4AL (QFhb-4AL, 621.85-622.24 Mb) and chromosome 5DL (QFhb-5DL, 546.09-547.27 Mb) which showed high collinearity in gene content and order. SNP markers wsnp_JD_c4438_5568170 and wsnp_CAP11_c209_198467 of 5D, reported previously linked to a soil-borne wheat mosaic virus (SBWMV) resistance gene, were also associated with FHB resistance in this study.
Conclusion: The syntenic FHB resistant loci and associated SNP markers identified in this study are valuable for FHB resistance breeding via marker-assisted selection.
Successful long-term remission through tapering tocilizumab infusions: a single-center prospective study
Authors: Ladhari Chayma , Blay Pierre Le , Vincent Thierry , Larbi Ahmed , Rubenstein Emma , Lopez Rosanna Ferreira , Jorgensen Christian , PERS Yves-Marie 
Published: November 2019

Abstract
Background: Strategic drug therapy for rheumatoid arthritis (RA) patients with prolonged remission is not well defined. According to recent guidelines, tapering biological Disease-Modifying Anti-Rheumatic Drugs (bDMARDs) may be considered. We aimed to evaluate the effectiveness of long-term maintenance of tocilizumab (TCZ) treatment after the progressive tapering of infusions. Methods: We conducted an exploratory, prospective, single-center, open-label study, on RA patients with sustained remission of at least 3 months and treated with TCZ infusions every 4 weeks. The initial re-treatment interval was extended to 6 weeks for the first 3 months. Thereafter, the spacing between infusions was determined by the clinician. Successful long-term maintenance following the tapering of TCZ infusions was defined by patients still treated after two years by TCZ with a minimum dosing interval of 5 weeks.Results: Thirteen patients were enrolled in the study. Eight out of thirteen were still treated by TCZ after two years. Successful long-term maintenance was possible in six patients, with four patients maintaining a re-treatment interval of 8-weeks or more. We observed 5 patients with TCZ withdrawal: one showing adverse drug reaction (neutropenia) and four with secondary failure. Patients achieving successful long-term maintenance with TCZ were significantly younger than those with secondary failure (p<0.05). In addition, RA patients with positive rheumatoid factor and anti-citrullinated peptide antibodies, experienced a significantly greater number of flares during our 2-year follow-up (p<0.01).Conclusions: A progressive tapering of TCZ infusions may be possible for many patients. However, larger studies, including more patients, are needed to confirm this therapeutic option.
Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis
Authors: Zhong Chunyu , Tan Shali , Ren Yutang , Lü MuHan , Peng Yan , Fu Xiangsheng , Tang Xiaowei 
Published: November 2019

Abstract
Background: Conventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowed for effective hemostasis for refractory GI bleeding lesions. So we aimed to conduct a systematic review to evaluate the effectiveness and safety of the OTSC system for management of acute non-variceal upper GI bleeding.
Method: A comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2007 to May 2019. The literature was selected independently by two reviewers according to the inclusion and exclusion criteria. The statistical analysis was carried out using Comprehensive Meta-Analysis software version 3.0.
Results: A total of 16 studies including 769 patients with 778 GI bleeding lesions were identified. Pooled technical success was achieved in 761 lesions [95.7%; 95% confidence interval (CI), 93.5%-97.2%], and the pooled clinical success was achieved in 666 lesions (84.2%; 95% CI, 77.4%-89.2%). The incidence of re-bleeding was reported in 81 patients and the post-procedure mortality was 10.9% (n = 84). Only 2 (0.3%) patients occurred complications after OTSC system procedure.
Conclusions: Our study demonstrated that the OTSC system was a technically feasible modality and highly efficacious in achieving hemostasis in acute non-variceal upper gastrointestinal bleeding.
Accuracy of Planar Anteversion Measurements using Anteroposterior Radiographs
Authors: Lee Gwang Chul , Lee Sang Hong , Kang Sin Wook , Park Hyung Suk , Jo Suenghwan 
Published: November 2019

Abstract
Background
Several methods using simple anteroposterior (AP) radiographs have been suggested for the measurement of anteversion of the cup component after total hip arthroplasty. Herein, we compared six widely used anteversion measurement methods using two different types of AP radiograph, the conventional pelvis AP and hip-centered AP radiographs, to identify the measurement method and the type of radiograph that would provide the highest accuracy and reliability.

Methods
We developed two custom-made bi-planar anteversion measurement models for the validation test. The models were designed for pelvis AP and hip-centered AP radiographs, respectively. The radiographs were acquired using the inclination angles of both models, changing from 10° to 70° at 10° increments. For each inclination angle, anteversion was changed from 0° to 30° at 5° increments. The measurements were obtained independently by two orthopedic surgeons blinded from each other’s measurements, using the methods of 1) Pradhan et al., 2) Lewinnek et al., 3) Widmer et al., 4) Liaw et al., 5) Hassan et al., and 6) Ackland et al. The measurements were repeated after 2 months. The accuracy, compared with that of the reference angle, and intra-observer and inter-observer reliabilities of each method were calculated.

Results
The highest accuracy was found when the method of Liaw et al. was used with hip-centered AP radiographs, which showed a difference of 1.37° ± 1.73 from the reference angle. Moreover, regardless of the type of radiograph, the methods by Pradhan et al., Lewinnek et al., and Liaw et al. showed excellent correlations with the reference anteversion. However, substantial differences were found when the methods by Widmer et al., Hassan et al., and Ackland et al. were used, regardless of the type of radiograph used. We also found no significant difference in anteversions between the measurements made on pelvic and hip-centered AP radiographs. Both interobserver and intraobserver reliabilities were high for all the measurements tested.

Conclusions
The methods by Pradhan et al., Liaw et al., and Lewinnek et al. may provide relatively accurate anteversion measurements with high reliability, regardless of the type of radiograph.
Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study
Authors: Chiu Hsien-Fu , Wen Mei-Chin , Wu Ming-Ju , Chen Cheng-Hsu , Yu Tung-Min , Chuang Ya-Wen , Huang Shih-Ting , Tsai Shang-Feng , Lo Ying-Chih , Ho Hao-Chung , Shu Kuo-Hsiung 
Published: November 2019

Abstract
Background: A plethora of evidences suggest that the most important cause of late graft loss in renal transplant recipients is chronic active antibody-mediated rejection. However, there are no consensus on treatment strategies.
Methods: We retrospectively analyzed clinical and pathological data of renal transplant recipients who received kidney graft biopsy with confirmed diagnosis of chronic active antibody-mediated rejection in the past 7 years. The patients were divided into two groups according to treatment strategy: Group 1: aggressive treatment (double filtration plasmapheresis and one of the followings: rituximab, intravenous immunoglobulin, antithymogycte globulin, bortezomib, or methylprednisolone pulse therapy); and group 2: supportive treatment.
Results: From February 2009 to December 2017, a total of 82 patients with biopsy-proven chronic antibody mediated rejection were identified. Kaplan-Meier analysis of death-censored graft survival showed a worse survival in group 2 ( P = 0.015 by log-rank test). Adverse event-free survival was lower in group 1, whereas patient survival was no significant different. Proteinuria and supportive treatment were independent risk factors for graft loss in multivariate analysis.
Conclusions : Aggressive treatment was associated with better graft outcome. However, higher incidence of adverse events merit personalized treatment, especially for those with higher risk of infection. Appropriate prophylactic antibiotics are recommended for aggressive treatment patients.
Key words: chronic active antibody mediated rejection, kidney transplantation, graft survival, adverse events
Diagnostic accuracy of history taking, physical examination and imaging for phalangeal, metacarpal and carpal fractures: a systematic review update.
Authors: Krastman Patrick , Mathijssen Nina M. , Bierma-Zeinstra Sita M.A. , Kraan Gerald , Runhaar Jos 
Published: November 2019

Abstract
Background The standard diagnostic work-up for hand and wrist fractures consists of history taking, physical examination and imaging if needed, but the supporting evidence for this work-up is limited. The purpose of this study was to systematically examine the diagnostic accuracy of tests for hand and wrist fractures. Methods A systematic search for relevant studies was performed. Methodological quality was assessed and sensitivity (Se), specificity (Sp), accuracy, positive predictive value (PPV) and negative predictive value (NPV) were extracted from the eligible studies. Results Of the 35 eligible studies, two described the diagnostic accuracy of history taking for hand and wrist fractures. Physical examination with or without radiological examination for diagnosing scaphoid fractures (five studies) showed Se, Sp, accuracy, PPV and NPV ranging from 15-100%, 13-98%, 55-73%, 14-73% and 75-100%, respectively. Physical examination with radiological examination for diagnosing other carpal bone fractures (one study) showed a Se of 100%, with the exception of the triquetrum (75%). Physical examination for diagnosing phalangeal and metacarpal fractures (one study) showed Se, Sp, accuracy, PPV and NPV ranging from 26-55%, 13-89%, 45-76%, 41-77% and 63-75%, respectively. Imaging modalities of scaphoid fractures showed predominantly low values for PPV and the highest values for Sp and NPV (24 studies). Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasonography (US) and Bone Scintigraphy (BS) were comparable in diagnostic accuracy for diagnosing a scaphoid fracture, with an accuracy ranging from 85-100%, 79-100%, 49-100% and 86-97%, respectively. Imaging for metacarpal and finger fractures showed Se, Sp, accuracy, PPV and NPV ranging from 73-100%, 78-100%, 70-100%, 79-100% and 70-100%, respectively. Conclusions Only two studies were found on the diagnostic accuracy of history taking for hand and wrist fractures in the current review. Physical examination was of moderate use for diagnosing a scaphoid fracture and of limited use for diagnosing phalangeal, metacarpal and remaining carpal fractures. MRI, CT and BS were found to be moderately accurate for the definitive diagnosis of clinically suspected carpal fractures.