bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Sources and Transport Dynamics of Eolian Sediments in the NE Tibetan Plateau Since 6.7 Ma
Authors: Li Xiaomiao , Peng Tingjiang , Ma Zhenhua , Li Meng , Li Peiye , Feng Zhantao , Guo Benhong , Yu Hao , Ye Xiyan , Zhang Jun , Song Chunhui , Li Jijun 
Published: February 2020

AbstractThe red clay and loess‐paleosol sediments of the Xiaoshuizi and Halagu planation surfaces of the northeastern Tibetan Plateau (TP) provide insights into the response of paleo‐atmospheric circulation and surface processes to TP uplift and global climate changes. We present silicate Sr‐Nd isotope compositions and bulk sediment grain‐size parameters of the red clay and loess‐paleosol sequences, with the aim of reconstructing changes in the transporting wind systems and sediment source regions. The results indicate that the red clay on the planation surface was transported mainly by the westerlies from the Tarim Basin and the Qilian Mountains, while the loess‐paleosol sediments were transported mainly by the East Asian winter monsoon (EAWM) from the Badain Jaran Desert, Tengger Desert, and Qaidam Basin. These shifts in transport mechanism and source were likely related to major changes in the topography of the TP and the expansion of Northern Hemisphere glaciation since the Middle Pliocene. In addition, we reconstructed the evolution of the paleo‐atmospheric circulation from the Late Miocene to the Middle Pliocene. During the Late Miocene, both the paleo‐EAWM and East Asian summer monsoon (EASM) were weak, and westerly winds dominated the climate of the study area. During the Early Pliocene, both the paleo‐EAWM and EASM exerted an increasing influence on the study area. We ascribe the slight enhancement of the paleo‐EAWM to the gradual growth of the northern TP and the significant enhancement of the paleo‐EASM to global climate changes.
Bayesian Elastic Full‐Waveform Inversion Using Hamiltonian Monte Carlo
Authors: Gebraad Lars , Boehm Christian , Fichtner Andreas 
Published: February 2020

AbstractWe present a proof of concept for Bayesian elastic full‐waveform inversion in 2‐D. This is based on (1) Hamiltonian Monte Carlo sampling of the posterior distribution, (2) the computation of misfit derivatives using adjoint techniques, and (3) a mass matrix tuning of the Hamiltonian Monte Carlo algorithm that accounts for the different sensitivities of seismic velocities and density. We apply our method to two synthetic end‐member scenarios with different dimension
that are particularly relevant in the context of full‐waveform inversion: low‐dimensional models (
) with potentially large variations in material parameters and high‐dimensional models (
> 30,000) describing smaller‐scale variations of lower amplitude relative to some background. For both end members, the Hamiltonian Monte Carlo sampling reliably recovers important aspects of the posterior, including means, covariances, skewness, and 1‐D and 2‐D marginals. Depending on the strength of material variations, the posterior can be significantly non‐Gaussian. This suggests to replace local methods for uncertainty quantification based on Gaussian assumptions by proper sampling of the posterior. In addition to P wave and S wave velocity, the sampling provides constraints on density structure that are free from subjective regularization artifacts.
Effect of nutritive and non-nutritive sweeteners on hemodynamic responses to acute stress: a randomized crossover trial in healthy women
Authors: Cros Jérémy , Bidlingmeyer Lucie , Rosset Robin , Seyssel Kevin , Crézé Camille , Stefanoni Nathalie , Schneiter Philippe , Tappy Luc 
Published: February 2020

Abstract
Background
The mechanisms by which chronic stress increases the risk of non-communicable diseases remain poorly understood. On one hand, chronic stress may increase systemic vascular resistance (SVR) and blood pressure, which may lead to blood vessels injury and altered myocardial perfusion. On the other hand, chronic stress may promote the overconsumption of sugar-containing foods and favor obesity. There is indeed evidence that sweet foods are preferentially consumed to alleviate stress responses. The effects of nutritive and non-nutritive sweeteners (NNS) on hemodynamic stress responses remain however largely unknown.

Objective/design
This study aimed at comparing the effects of sucrose-containing and NNS-containing drinks, as compared to unsweetened water, on hemodynamic responses to acute stress in twelve healthy female subjects. Acute stress responses were elicited by a 30-min mental stress (5-min Stroop’s test alternated with 5-min mental arithmetic) and a 3-min cold pressure test (CPT), each preceded by a resting baseline period. Hemodynamic stress responses were investigated by the repeated measurement of mean arterial pressure and the continuous monitoring of cardiac output by thoracic electrical bioimpedance measurement. SVR was selected as a primary outcome because it is a sensitive measure of hemodynamic responses to acute stress procedures.

Results
With all three drinks, SVR were not changed with mental stress (P = 0.437), but were increased with CPT (P = 0.045). Both mental stress and CPT increased mean arterial pressure and heart rate (all P < 0.001). Cardiac output increased with mental stress (P < 0.001) and remained unchanged with CPT (P = 0.252). No significant differences in hemodynamic responses were observed between water, sucrose and NNS (stress × condition, all P > 0.05).

Conclusions
These results demonstrate that sucrose and NNS do not alter hemodynamic responses to two different standardized acute stress protocols.
Acceptance-based therapy: the potential to augment behavioral interventions in the treatment of type 2 diabetes
Authors: Cardel Michelle I. , Ross Kathryn M. , Butryn Meghan , Donahoo W. Troy , Eastman Abraham , Dillard Julia R. , Grummon Anna , Hopkins Patrick , Whigham Leah D. , Janicke David 
Published: February 2020

AbstractDiabetes is a complex and multifactorial disease affecting more than 415 million people worldwide. Excess adiposity and modifiable lifestyle factors, such as unhealthy dietary patterns and physical inactivity, can play a significant role in the development of type 2 diabetes. Interventions that implement changes to lifestyle behaviors, in addition to pharmacological treatment, may attenuate the development and worsening of diabetes. This narrative review delineates how standard behavioral interventions (SBTs), based in “first wave” behavioral therapies and “second wave” cognitive behavioral therapies, serve as the foundation of diabetes treatment by supporting effective lifestyle changes, including improving adherence to healthful behaviors, medication, and self-monitoring regimens. Moreover, “third wave” “acceptance-based therapies” (ABTs), which integrate techniques from acceptance and commitment therapy, are proposed as a potential novel treatment option for diabetes management. Further research and long-term, randomized controlled trials will clarify the feasibility, acceptability, and effectiveness of ABT for improving glucose control via enhancing medication adherence and promoting effective lifestyle changes in people with diabetes.
Circadian rhythm disruption and mental health
Authors: Walker William H. , Walton James C. , DeVries A. Courtney , Nelson Randy J. 
Published: February 2020

AbstractCircadian rhythms are internal manifestations of the solar day that permit adaptations to predictable environmental temporal changes. These ~24-h rhythms are controlled by molecular clockworks within the brain that are reset daily to precisely 24 h by exposure to the light–dark cycle. Information from the master clock in the mammalian hypothalamus conveys temporal information to the entire body via humoral and neural communication. A bidirectional relationship exists between mood disorders and circadian rhythms. Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion, whereas disruption of circadian rhythms via jet lag, night-shift work, or exposure to artificial light at night, can precipitate or exacerbate affective symptoms in susceptible individuals. Evidence suggests strong associations between circadian rhythms and mental health, but only recently have studies begun to discover the direct interactions between the circadian system and mood regulation. This review provides an overview of disrupted circadian rhythms and the relationship to behavioral health and psychiatry. The focus of this review is delineating the role of disruption of circadian rhythms on mood disorders using human night shift studies, as well as jet lag studies to identify links. We also review animal models of disrupted circadian rhythms on affective responses. Lastly, we propose low-cost behavioral and lifestyle changes to improve circadian rhythms and presumably behavioral health.
Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial
Authors: Ng Ted Kheng Siang , Fam Johnson , Feng Lei , Cheah Irwin Kee-Mun , Tan Crystal Tze-Ying , Nur Fadzillah , Wee Sin Tho , Goh Lee Gan , Chow Wei Ling , Ho Roger Chun-Man , Kua Ee Heok , Larbi Anis , Mahendran Rathi 
Published: February 2020

AbstractFew randomized controlled trials investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Furthermore, there have been hypotheses and theoretical mechanisms on the benefits of mindfulness intervention on biomarkers of stress, inflammation, and neuroplasticity implicated in MCI that warrant empirical evidence. We conducted a pilot randomized controlled trial to examine whether Mindful Awareness Practice (MAP) improved biomarker levels in older adults with MCI. Fifty-five community-dwelling older adults aged 60 and above were randomized into either the treatment arm, MAP, or the active control arm, the health education program (HEP). Researchers who were blinded to treatment allocation assessed the outcomes at baseline, 3-month, and 9-month follow-ups. Linear-mixed models were used to examine the effect of MAP on biomarker levels. MAP participants had significantly decreased high-sensitivity c-reactive protein (hs-CRP) levels at 9-month (β = −0.307, 95% CI = −0.559 to −0.054P = 0.018). Exploratory sub-group analyses by sex showed significantly decreased hs-CRP in females only (β = −0.445, 95% CI = −0.700 to −0.189,P = 0.001), while stratification by MCI subtype showed hs-CRP decreased only in amnestic-MCI (aMCI) (β = −0.569, 95% CI = −1.000 to −0.133,P = 0.012). Although total sample analyses were not significant, males had significantly decreased interleukin (IL)−6 (β = −1.001, 95% CI = −1.761 to −0253,P = 0.011) and IL-1β (β = −0.607, 95% CI = −1.116 to −0.100,P = 0.021) levels at 3-month and non-significant improvements at 9-month time-point. MAP improved inflammatory biomarkers in sex- and MCI subtype-specific manners. These preliminary findings suggest the potential of mindfulness intervention as a self-directed and low-cost preventive intervention in improving pathophysiology implicated in MCI.
Neurometabolic correlates of 6 and 16 weeks of treatment with risperidone in medication-naive first-episode psychosis patients
Authors: Birur Badari , Kraguljac Nina Vanessa , VerHoef Lawrence , Morgan Charity J. , Jindal Ripu Daman , Reid Meredith Amanda , Luker Austin , Lahti Adrienne Carol 
Published: February 2020

AbstractAntipsychotic medications are the cornerstone of treatment in schizophrenia spectrum disorders. In first-episode psychosis, the recommended time for an antipsychotic medication trial is up to 16 weeks, but the biological correlates of shorter and longer antipsychotic treatment trials in these cohorts remain largely unknown. We enrolled 29 medication-naive first-episode patients (FEP) and 22 matched healthy controls (HC) in this magnetic resonance spectroscopy (MRS) study, examining the levels of combined glutamate and glutamine (commonly referred to as Glx) in the bilateral medial prefrontal cortex (MPFC) with a PRESS sequence (TR/TE = 2000/80 ms) before initiation of antipsychotic treatment, after 6 and 16 weeks of treatment with risperidone. Data were quantified in 18 HC and 20 FEP at baseline, for 19 HC and 15 FEP at week 6, and for 14 HC and 16 FEP at week 16. At baseline, none of the metabolites differed between groups. Metabolite levels did not change after 6 or 16 weeks of treatment in patients. Our data suggest that metabolite levels do not change after 6 or 16 weeks of treatment with risperidone in FEP. It is possible that our choice of sequence parameters and the limited sample size contributed to negative findings reported here. On the other hand, longer follow-up may be needed to detect treatment-related metabolic changes with MRS. In summary, our study adds to the efforts in better understanding glutamatergic neurometabolism in schizophrenia, especially as it relates to antipsychotic exposure.
Sedentary behaviors and risk of depression: a meta-analysis of prospective studies
Authors: Huang Yuchai , Li Liqing , Gan Yong , Wang Chao , Jiang Heng , Cao Shiyi , Lu Zuxun 
Published: February 2020

AbstractEpidemiological evidence on the association between sedentary behaviors and the risk of depression is inconsistent. We conducted a meta-analysis of prospective studies to identify the impact of sedentary behaviors on the risk of depression. We systematically searched in the PubMed and Embase databases to June 2019 for prospective cohort studies investigating sedentary behaviors in relation to the risk of depression. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated with random-effect meta-analysis. In addition, meta-regression analyses, subgroup analyses, and sensitivity analyses were performed to explore the potential sources of heterogeneity. Twelve prospective studies involving 128,553 participants were identified. A significantly positive association between sedentary behavior and the risk of depression was observed (RR = 1.10, 95% CI 1.03–1.19, I2 = 60.6%, P < 0.01). Subgroup analyses revealed that watching television was positively associated with the risk of depression (RR = 1.18, 95% CI 1.07–1.30), whereas using a computer was not (RR = 0.99, 95% CI 0.79–1.23). Mentally passive sedentary behaviors could increase the risk of depression (RR = 1.17, 95% CI 1.08–1.27), whereas the effect of mentally active sedentary behaviors were non-significant (RR = 0.98, 95% CI 0.83–1.15). Sedentary behaviors were positively related to depression defined by clinical diagnosis (RR = 1.08, 95% CI 1.03, 1.14), whereas the associations were statistically non-significant when depression was evaluated by the CES-D and the Prime-MD screening. The present study suggests that mentally passive sedentary behaviors, such as watching television, could increase the risk of depression. Interventions that reduce mentally passive sedentary behaviors may prevent depression.
Association between visual acuity, lesion activity markers and retreatment decisions in neovascular age-related macular degeneration
Authors: Chakravarthy Usha , Pillai Natasha , Syntosi Annie , Barclay Lorna , Best Catherine , Sagkriotis Alexandros 
Published: February 2020

Abstract
Background/objectives
To investigate the association between optical coherence tomography (OCT) markers of lesion activity and changes in visual acuity (VA) during anti-vascular endothelial growth factor (anti-VEGF) therapy of eyes diagnosed with neovascular age-related macular degeneration (nAMD); and how VA and OCT markers are considered in physicians’ decision to retreat with anti-VEGFs.

Subjects/methods
Retrospective, non-comparative, non-randomised cohort study involving electronic medical record data collected from 1190 patient eyes with nAMD diagnosis at two sites in the United Kingdom. Two sub-cohorts consisting of 321 and 301 eyes, respectively, were selected for analyses.

Results
In 321 eyes, absence of IRF or SRF at ≥2 clinic visits resulted in a gain of five ETDRS letters from baseline, compared with two letters gained in eyes with <2 clinic visits with absence of IRF (p = 0.006) or SRF (p = 0.042). Anti-VEGF treatment was administered at 421 clinic visits, and 308 visits were without treatment. Comparing treatment visits with non-treatment visits, the maximum difference in frequency of OCT markers of lesion activity were for intraretinal fluid (IRF; 24% versus 5%) and subretinal fluid (SRF; 32% versus 5%). Pigment epithelial detachment (PED) was reported in 58% of treatment visits compared with 36% in non-treatment visits. VA loss was not a consistent trigger for retreatment as it was present in 63% of injection visits and in 49% of non-injection visits.

Conclusions
Retreatment decision making is most strongly influenced by the presence of IRF and SRF and less by the presence of PED or VA loss.
The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
Authors: Zhang Aihua , Yu Hua , Liu Chunhong , Song Chen 
Published: February 2020

AbstractRyanodine receptors (RyR) are ion channels responsible for the release of Ca2+ from the sarco/endoplasmic reticulum and play a crucial role in the precise control of Ca2+ concentration in the cytosol. The detailed permeation mechanism of Ca2+ through RyR is still elusive. By using molecular dynamics simulations with a specially designed Ca2+ model, we show that multiple Ca2+ ions accumulate in the upper selectivity filter of RyR1, but only one Ca2+ can occupy and translocate in the narrow pore at a time, assisted by electrostatic repulsion from the Ca2+ within the upper selectivity filter. The Ca2+ is nearly fully hydrated with the first solvation shell intact during the whole permeation process. These results suggest a remote knock-on permeation mechanism and one-at-a-time occupation pattern for the hydrated Ca2+ within the narrow pore, uncovering the basis underlying the high permeability and low selectivity of the RyR channels.
Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation
Authors: Hernandez-Sanabria Emma , Heiremans Evelien , Calatayud Arroyo Marta , Props Ruben , Leclercq Laurent , Snoeys Jan , Van de Wiele Tom 
Published: February 2020

AbstractCelecoxib has been effective in the prevention and treatment of chronic inflammatory disorders through inhibition of altered cyclooxygenase-2 (COX-2) pathways. Despite the benefits, continuous administration may increase risk of cardiovascular events. Understanding microbiome-drug-host interactions is fundamental for improving drug disposition and safety responses of colon-targeted formulations, but little information is available on the bidirectional interaction between individual microbiomes and celecoxib. Here, we conducted in vitro batch incubations of human faecal microbiota to obtain a mechanistic proof-of-concept of the short-term impact of celecoxib on activity and composition of colon bacterial communities. Celecoxib-exposed microbiota shifted metabolic activity and community composition, whereas total transcriptionally active bacterial population was not significantly changed. Butyrate production decreased by 50% in a donor-dependent manner, suggesting that celecoxib impacts in vitro fermentation. Microbiota-derived acetate has been associated with inhibition of cancer markers and our results suggest uptake of acetate for bacterial functions when celecoxib was supplied, which potentially favoured bacterial competition for acetyl-CoA. We further assessed whether colon microbiota modulates anti-inflammatory efficacy of celecoxib using a simplified inflammation model, and a novel in vitro simulation of the enterohepatic metabolism. Celecoxib was responsible for only 5% of the variance in bacterial community composition but celecoxib-exposed microbiota preserved barrier function and decreased concentrations of IL-8 and CXCL16 in a donor-dependent manner in our two models simulating gut inflammatory milieu. Our results suggest that celecoxib-microbiome-host interactions may not only elicit adaptations in community composition but also in microbiota functionality, and these may need to be considered for guaranteeing efficient COX-2 inhibition.
Four-point impedance as a biomarker for bleeding during cochlear implantation
Authors: Bester Christofer , Razmovski Tayla , Collins Aaron , Mejia Olivia , Foghsgaard Søren , Mitchell-Innes Alistair , Shaul Chanan , Campbell Luke , Eastwood Hayden , O’Leary Stephen 
Published: February 2020

AbstractCochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.
The last Palaeoproteus (Urodela: Batrachosauroididae) of Europe
Authors: Vasilyan Davit , Yanenko Vadym 
Published: February 2020

AbstractThe Batrachosauroididae are an enigmatic group of salamanders known from the Cretaceous and Tertiary of North America and Europe. In Europe, the family is known only by two species of the genus Palaeoproteus. The genus has limited distribution in Western and Central Europe. In the present paper, we describe a new species, Palaeoproteus miocenicus, from the early late Miocene (11–9 Ma) of Austria and Ukraine, representing the youngest record of the family Batrachosauroididae from the Neogene of Europe. The new species differs from the Paleogene representatives of the genus by 12 characters, including large body size, the long anterior extension of the Meckelian groove and the size and shape of the odontoid process on the dentary. The µCT scanning of bones of the new species revealed novel features (e.g. anterior extension of Meckelian groove, interconnected network of canals and small cavities in atlas) observable only in this species. P. miocenicus inhabited aquatic environments, which existed under wet climatic conditions with mean annual precipitation higher than 900 mm. The new species expands the temporal range of the genus by at least 30 million years and enlarges the palaeogeographic distribution of the genus into Eastern Europe.