bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANCANG BANGUN APLIKASI PEMBUATAN LAPORAN PRAKTIKUM BERBASIS WEB PADA SMK
Authors: Khusnia Riezka Layli , Tamrin A.G , Efendi Agus 
Published: December 2020

<p>Penelitian ini bertujuan untuk membangun aplikasi pembuatan laporan praktikum yang berguna untuk memudahkan siswa dalam membuat laporan praktikum. Aplikasi ini dibuat untuk digunakan di lembaga pendidikan, terutama pada siswa Sekolah Menengah Kejuruan (SMK) yang sering terjun untuk melakukan praktik. Aplikasi ini berbasis <em>web</em> yang langsung terkoneksi dengan guru, sehingga hasil laporan siswa dapat dilihat dan dinilai oleh guru. Metode yang digunakan dalam penelitian ini adalah metode penelitian dan pengembangan (R&amp;D) menggunakan model pengembangan Borg &amp; Gall. Penelitian ini dilaksanakan di SMK Negeri 1 Sawit. Teknik pengumpulan data yaitu melalui wawancara, menyebarkan lembar penilaian dan dokumentasi. Rancang bangun aplikasi pembuatan laporan praktikum berbasis <em>web</em> pada SMK melalui sepuluh tahap yaitu: (1) Potensi dan masalah. (2) Pengumpulan data. (3) Desain produk, berupa membuat rancangan <em>use case diagram</em>, <em>flowchart</em>, DFD, ERD, pembuatan desain tampilan, pembuatan basis data dan pembuatan aplikasi. (4) Validasi desain, berupa pengujian yang dilakukan oleh ahli media. (5) Revisi desain, yaitu revisi dari ahli media. (6) Uji coba produk, berupa pengujian perorangan. (7) Revisi produk, yaitu revisi tahap I. (8) Uji coba pemakaian, berupa pengujian oleh kelompok kecil. (9) Revisi produk, yaitu revisi tahap II. (10) Produk akhir aplikasi, yaitu hasil akhir aplikasi pembuatan laporan praktikum berbasis <em>web</em> pada SMK. Hasil penelitian dari aplikasi pembuatan laporan praktikum mendapatkan nilai dalam bentuk persentase sebesar 89% dari ahli media, 91% dari kelompok kecil dan 81% dari kelompok luas. Sehingga, aplikasi pembuatan laporan praktikum berbasis <em>web</em> pada SMK masuk dalam kategori sangat layak digunakan dalam pembuatan laporan praktikum.</p><p><strong>Kata Kunci:</strong> praktik, laporan praktikum, SMK, berbasis <em>web</em></p>
Pulmonary cavitation in patients with thyroid cancer receiving antiangiogenic agents
Authors: Datar Saumil , Cabanillas Maria , Dadu Ramona , Ost David , Grosu Horiana 
Published: December 2020

Abstract
Background: Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment. However, TKIs have been associated with an increased risk of tumor cavitation, in turn linked to poor outcomes, in patients with malignancies in the lungs, where thyroid cancer commonly metastasizes. Method: We performed a retrospective cohort study of patients with thyroid cancer and evidence of metastatic disease to the lung that were treated with multi-targeted antiangiogenic TKIs. The primary objective of this study was to determine the incidence of pulmonary cavitation. The secondary objective was to evaluate the effect of pulmonary cavitation on survival. Results: Of the 83 patients with pulmonary nodules,10 developed cavitation during treatment. Of these 83 patients, two patients had to stop the treatment due to pneumothorax. Additionally, cavitation did not demonstrate any significant effect on survival. Conclusion: In patients with thyroid cancer and evidence of metastatic disease to the chest, the use of multi-targeted TKIs led to cavitations that were not uncommon but clinical consequences were marginal. Treatment was stopped only in two patients that developed pneumothorax, however the small sample is a strong limitation of our study.
Unmet supportive care needs and associated factors among young adult cancer patients in Japan
Authors: Okamura Masako , Fujimori Maiko , Sato Ayako , Uchitomi Yosuke 
Published: December 2020

Abstract
Background: Young adult cancer patients often face unique challenges and have potential unmet needs. This study aimed (1) to describe unmet supportive care needs among young adults with cancer in Japan, and (2) to identify its associated factors.Methods: In a cross-sectional web-based survey, 206 young adults with cancer were assessed for supportive care needs. Multiple regression analysis examined whether demographics, clinical variables and social support were associated with unmet supportive care needs.Results: A total of 206 patients (180 female) with a mean age of 33.7 years (SD=4.3, range: 22-39) participated. One hundred and fifty-eight participants (76.7%) reported at least one unmet supportive care needs. The top 20 unmet needs included 9 of the 10 psychological needs, 3 of the 5 physical and daily living needs, 8 of the 11 health system and information needs and 1 of the 5 sexuality needs. Multiple regression analysis revealed that perceived poorer PS, experience of change in work/school after a cancer diagnosis and poor social support were significantly associated with higher supportive care needs. The total score of supportive care needs was significantly associated with both psychological distress and QOL.Conclusions: More than 70% of young adult cancer patients reported unmet supportive care needs and most of those were psychological needs. The findings suggest potential opportunities for intervention in addressing psychological needs rather than physical and information needs.
Trends in the utilization of youth primary healthcare services and psychological distress
Authors: Potrebny Thomas , Wiium Nora , Haugstvedt Anne , Sollesnes Ragnhild , Wold Bente , Thuen Frode 
Published: December 2020

Abstract
BackgroundPsychological distress among young people is increasing in Northern Europe. According to established healthcare utilization theory, this will create a greater need for youth primary healthcare and subsequently lead to more help-seeking behavior by distressed young people. The aim of this study was to investigate the association between the use of youth primary healthcare services and psychological distress in times of increasing mental health problems and increased service need.MethodsThis study consisted of five waves of repeated annual cross-sectional data collected from young people (aged 13-19) living in Norway between 2014 and 2018 (n = 368,579). Population-weighted and design-adjusted generalized linear regression with a log-link was used to examine the use of youth primary healthcare services over time. ResultsWe found that a large proportion of young people use primary healthcare services and that young people with high levels of psychological distress use primary healthcare services twice as much as their peers with low levels of psychological distress. In addition, between 2014 and 2018 both psychological distress and primary healthcare service utilization increased: psychological distress increased by 5% and total primary healthcare service use increased by 500 consultations per 1000 young people. Overall, psychological distress had a conditional association with youth primary healthcare service use and could account for between 16-66% of the change in the use of services between 2014 and 2018, depending on the service type. However, the absolute increase seen in the use of primary healthcare services was mainly driven by young people with low levels of psychological distress as opposed to young people with high psychological distress. This suggest a converging trend.ConclusionsOur findings suggest that there might be serious barriers between need and help-seeking behavior for young people with high levels of psychological distress and that the pattern of utilization among young people with lower distress may indicate overuse, possibly as an inadvertent consequence of a newly introduced school absence policy. While further research is needed to confirm these findings, our work may inform healthcare providers and policy makers about primary healthcare utilization trends among young people.
Expression and Function of Modulator of Apoptosis (MOAP-1) in Blood Cancers
Authors: Law Jennifer , Svystun Orysya , Flood Kayla , Fahlman Richard , Kerek Evan , Hubbard Basil , Narendran Aru , Baksh Shairaz 
Published: December 2020

Abstract
Background: The function of the Ras association domain family 1 (RASSF1)/modulator of apoptosis 1 (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood cancers by epigenetic loss of RASSF1A via promoter specific methylation. However, a detailed analysis of expression and stability of MOAP-1 as well as effect on cellular proliferation and cell death in blood cancers has not been explored. Methods: Expression of MOAP-1 RASSF1A was performed by immunoblotting analysis, MOAP-1 effect on biology determined by cell proliferation, cell death and tumorigenicity assays. Lastly, proteomic analysis in MOAP-1 in form 1 and 2 expressing cells reveal new interacting partners to MOAP-1. Results: The expression of MOAP-1 appears to be quite varied and exists as two forms, a p39 and p46 form in blood cancers. The higher MOAP-1 p46 form was mainly observed in acute myeloid leukemia (AML) and some acute lymphocytic leukemia (ALL) patients and cell lines. Furthermore, MOAP-1 p46 form can be reduced to the p39 form upon calf intestinal or lambda phosphatase treatment, suggesting post-translational phosphorylation likely produces the slower migrating form. Blood cancer cell lines containing the p46 form of MOAP-1 appears to be more resistant to cell death signals and have increased growth. In addition, we document in vivo protection from tumorigenesis of cells containing MOAP-1 following tail vein injection of cancer cells. Lastly, proteomic analysis revealed several interesting components of the MOAP-1 interactome in blood cancer cells that we validated. Conclusions: MOAP-1 is a bona fide tumor suppressor in blood cancers with functions beyond apoptosis.
Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures
Authors: Jia Shuyong , Wang Qizhen , Li Hongyan , Song Xiaojing , Wang Shuyou , Zhang Weibo , Wang Guangjun 
Published: December 2020

Abstract
Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of SkBF after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of SkBF at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. Stimulation at 4 °C and 10 °C resulted in a decrease in the DF of the EGG and an increased RMSSD of the RR interval. Although this laterality is mainly contributed to by frequency interval V, there was a weak negative correlation between the laterality index of frequency interval I or II and RMSSD.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.
Electrochemical activation of C–H by electron-deficient W2C nanocrystals for simultaneous alkoxylation and hydrogen evolution
Authors: Lin Xiu , Zhang Shi-Nan , Xu Dong , Zhang Jun-Jun , Lin Yun-Xiao , Zhai Guang-Yao , Su Hui , Xue Zhong-Hua , Liu Xi , Antonietti Markus , Chen Jie Sheng , Li Xin-Hao 
Published: December 2020

Abstract
Activation of C − H bonds is maybe the central challenge in organic chemistry and usually the key step for the retro-synthesis of functional natural products and medicines from abundant hydrocarbons due to the high chemical stability of C − H bonds. Electrochemical methods are now recognized as a powerful alternative for C − H activation, but this approach usually requires high overpotential and homogeneous mediators. Here, we designed electron-deficient W2C nanocrystal-based electrodes to boost the heterogeneous activation of C − H bonds under mild conditions via an additive-free, purely heterogeneous electrocatalytic strategy. The electron density of W2C nanocrystals was tuned by constructing Schottky heterojunctions with nitrogen-doped carbon support to facilitate the preadsorption and activation of benzylic C − H bonds of ethylbenzene on the W2C surface, enabling a high turnover frequency (18.8 h− 1) at a comparably low work potential (2 V versus SCE). The pronounced electron deficiency of the W2C nanocatalysts substantially facilitates the direct deprotonation process to ensure long-term electrode durability without self-oxidation. The efficient oxidation process also boosts the balancing hydrogen production from as-formed protons on the cathode by a factor of 10 compared to an inert reference electrode. The whole process meets the requirements of atomic economy and electric energy utilization in terms of sustainable chemical synthesis.
Anti-Gastric Cancer Effect of Purified Omphalia Lapidescens Protein via Regulating the&nbsp;JAK/STAT3 Signaling Pathway
Authors: Xu Wenjun , Lu Zhongxia , Cheung Man Hei , Xu Yuqin , Lin Meiai , Liang Chun , Lou Jianshu , Chen Yitao 
Published: December 2020

Abstract
Background: Gastric cancer is the leading cause of cancer-related death worldwide. The aim of present study was to investigate the anti-tumor effect of purified Omphalia lapidescens protein (pPeOp) in gastric cancer.Methods: Microarray analysis was performed to find out differentially expressed genes in pPeOp-treated MC-4 gastric cancer cells. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 signaling pathway was most likely to be altered after bioinformatics analysis. Interleukin-6 (IL-6) and NSC74859 were used as the agonist and inhibitor of the JAK/STAT3 signaling pathway, respectively. Flow cytometry and MTS assay were used for cell proliferation and viability analysis in pPeOp-treated gastric cell lines with IL-6 or NSC74859.Results: The anti-tumor effect was increased when pPeOp were co-treated with IL-6, while decreased in inhibitor treatment. The expression of the crucial members in the pathway of MC-4 cells, including glycoprotein 130 (GP130), JAK1, JAK2, STAT3, p-STAT3, suppressor of cytokine signaling SOCS1 and SOCS3, was investigated by western blotting.Conclusion: pPeOp exhibited promising anticancer effect in the xenograft nude mice model, established by STAT3 knock down gastric cancer cells. Thus, JAK/STAT3 inhibition partially contributed to the anticancer effect of pPeOp, which may serve as a novel strategy for gastric cancer.
Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium through Repressing Gsx2
Authors: Wen Yan , Su Zihao , Wang Ziwu , Yang Lin , Liu Guoping , Shang Zicong , Duan Yangyang , Du Heng , Li Zhenmeiyu , You Yan , Li Xiaosu , Yang Zhengang , Zhang Zhuangzhi 
Published: December 2020

Abstract
Specification of the progenitors’ regional identity is a pivotal step during development of the cerebral cortex and basal ganglia. The molecular mechanisms underlying progenitor regionalization, however, are poorly understood. Here we showed that the transcription factors Vax1 was highly expressed in the developing subpallium. In its absence, the RNA-Seq analysis, in situ RNA hybridization, and immunofluorescence staining results showed that the cell proliferation was increased in the subpallium, but the neuronal differentiation was blocked. Moreover, the dLGE region severely expanded ventrally at the expense of the vLGE, MGE, and septum. Finally, overexpressed VAX1 in the LGE progenitors strongly inhibits Gsx2 expression. Taken together, our findings show that Vax1 is crucial for subpallium regionalization by repressing Gsx2.
Ensemble Bootstrap Methodology for Forecasting Dynamic Growth Processes Using Differential Equations: Application to Epidemic Outbreaks
Authors: Chowell Gerardo , Luo Ruiyan 
Published: December 2020

Abstract
Background: Ensemble modeling aims to boost the forecasting performance by systematically integrating the predictive accuracy across individual models. Here we introduce a simple-yet-powerful ensemble methodology for forecasting the trajectory of dynamic growth processes, such as the spread of infectious diseases, that are defined by a system of non-linear differential equations. Methods: We propose and assess the performance of two ensemble modeling schemes with different parametric bootstrapping procedures for trajectory forecasting and uncertainty quantification. Specifically, we conduct sequential probabilistic forecasts to evaluate their forecasting performance using simple dynamical growth models with good track records including the Richards model, the generalized-logistic growth model, and the Gompertz model. We first demonstrate the functionality of the method using simulated data from phenomenological models and a mechanistic transmission model. Next, the performance of the method is demonstrated using a diversity of epidemic datasets including scenario outbreak data of the Ebola Forecasting Challenge and real-world epidemic data outbreaks of including influenza, plague, Zika, and COVID-19. Results: We found that the ensemble method that randomly selects a model from the set of individual models for each time point of the trajectory of the epidemic frequently outcompetes the individual models as well as an alternative ensemble method based on the weighted combination of the individual models and yields broader and more realistic uncertainty bounds for the trajectory envelope and achieves not only better coverage rate of the 95% prediction interval but also improved mean interval scores across a diversity of epidemic datasets.Conclusion: We introduced new methodology for ensemble forecasting that outcompetes component models and an alternative ensemble model that differ in how the variance is evaluated for the generation of the prediction intervals of the forecasts.
The Impact of Body Concerns and Body Mass on Subjective Health and Self-Esteem in Early Adolescence. A Longitudinal Cohort Study
Authors: Meland Eivind , Breidablik Hans , Thuen Frode , Samdal Gro 
Published: December 2020

Abstract
Background Impaired self-rated health (SRH) and self-esteem (SE) in adolescents are associated with increased body mass index (BMI). These associations are often studied using cross-sectional designs. The relations studied in longitudinal designed studies seem complex.Methods A longitudinal cohort study of 1225 Norwegian high school students, with SRH, SE and BMI as primary outcomes. We reported the results from temporal causal and residual change analyses separately, with odds ratios (ORs) and standardized regression coefficients (b) and 95% confidence limits.Results Body and weight concerns had unfavourable effects on SRH and SE, which both had favourable effects on each other. Increased BMI had unfavourable effects on SRH, but less so on SE. Body and weight concerns impacted SE change only among girls. Paradoxically, the intention of becoming thinner was associated with an increase in BMI, and the intention of becoming fatter predicted a decrease in BMI during the two years. SE and SRH were associated with a leaner body after two years.Conclusions This study confirms that BMI, SE, SRH, body shape and body weight concerns were reciprocally associated with complex inter-relations. Health promotion strategies built on body acceptance should be increasingly emphasized both in clinical and in public health practice.
The Role of Social Capital on Covid-19 Deaths
Authors: Arachchi Janaki Imbulana , Managi Shunsuke 
Published: December 2020

Abstract
Background: Covid-19 pandemic shows a continuously increasing trend with a huge variation in the number of Covid-19 deaths across countries. In response, many countries have implemented non-pharmaceutical methods of intervention such as social distancing and lockdowns. This study aims to investigate the relationship between the four dimensions of social capital (community attachment, social trust, family bond, and security) with several control variables of Covid-19 deaths. Methods: We retrieved data from open access databases and our survey data. Covid-19 deaths related data were collected from the website “Center for Systems Science and Engineering (CSSE) at Johns Hopkins University”. Social capital related data was collected from a large-scale survey of 100,956 respondents across 37 countries that including web-based and face-to-face surveys covering all regions/provinces/states of 37 countries in 2017. Data regarding population density, hospital beds numbers, and population age 65 or older, was retrieved from the World Development Indicators (WDI). Data on country lockdown was obtained from the website “National responses to the 2019-20 coronavirus pandemic”. Linear regressions were applied to identify the relationship between social capital and Covid-19 deaths. Results: We found that Covid-19 deaths are associated with social capital both positively and negatively. Community attachment and social trust were associated with more Covid-19 deaths and family bond and security were associated with less deaths. Covid-19 deaths were positively associated with population density, aging population, and interactions between four dimensions of social capital related factors and aging population. Furthermore, number of hospital beds and early lockdown policy were negatively associated with Covid-19 deaths. Conclusions: The results indicate that the role of social capital on dynamically evolving threats such as the current Covid-19 pandemic does not always negatively or positively. Therefore, countries require changes of behavior of people to response Covid-19 threat.
Designing Crystallization to Tune the Performance of Phase-Change Memory: Rules of Hierarchical Melt and Coordinate Bond
Authors: Zhao Jin , Song Wenxiong , Xin Tianjiao , Song Zhitang 
Published: December 2020

Abstract
While alloy design has practically shown an efficient strategy to mediate two seemingly conflicted performances of writing speed and data retention in phase-change memory, the detailed kinetic pathway of alloy-tuned crystallization is still unclear. Here, we propose hierarchical melt and coordinate bond strategies to solve them, where the former stabilizes a medium-range crystal-like region and the latter provides a rule to stabilize amorphous. The Er0.52Sb2Te3 compound we designed achieves writing speed of 3.2ns and ten-year data retention of 161°C. We provide a direct atomic-level evidence that two neighbor Er atoms stabilize a medium-range crystal-like region, acting as a precursor to accelerate crystallization; meanwhile, the essential reason of stabilization originates from the formation of coordinate bonds by sharing lone-pair electrons of chalcogenide atoms with the empty d orbitals of Er atoms. The two rules pave the way for the development of storage-class memory with excellent comprehensive performance to achieve next revolutionary technology node.