bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term safety of paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease: the SPARTAN DCB study
Authors: Merinopoulos Ioannis , Gunawardena Tharusha , Wickramarachchi Upul , Richardson Paul , Maart Clint , Sreekumar Sulfi , Sawh Chris , Wistow Trevor , Sarev Toomas , Ryding Alisdair , Gilbert Tim , Perperoglou Aris , Vassiliou Vassilios S. , Eccleshall Simon C. 
Published: September 2020

Abstract
Objectives
We aimed to investigate long-term survival of paclitaxel DCB for percutaneous coronary intervention (PCI).

Background
Safety concerns have been raised over the use of paclitaxel devices for peripheral artery disease recently, following a meta-analysis suggesting increased late mortality. With regard to drug-coated balloon (DCB) angioplasty for coronary artery intervention however, there is limited data to date regarding possible late mortality relating to paclitaxel.

Methods
We compared all-cause mortality of patients treated with paclitaxel DCB to those with non-paclitaxel second-generation drug-eluting stents (DES) for stable, de novo coronary artery disease from 1st January 2011 till 31st December 2018. To have homogenous groups allowing data on safety to be interpreted accurately, we excluded patients with previous PCI and patients treated with a combination of both DCB and DES in subsequent PCIs. Data were analysed with Kaplan–Meier curves and Cox regression statistical models.

Results
We present 1517 patients; 429 treated with paclitaxel DCB and 1088 treated with DES. On univariate analysis, age, hypercholesterolaemia, hypertension, peripheral vascular disease, prior myocardial infarction, heart failure, smoking, atrial fibrillation, decreasing estimated glomerular filtration rate (eGFR) [and renal failure (eGFR < 45)] were associated with worse survival. DCB intervention showed a non-significant trend towards better prognosis compared to DES (p = 0.08). On multivariable analysis age, decreasing eGFR and smoking associated with worse prognosis.

Conclusion
We found no evidence of late mortality associated with DCB angioplasty compared with non-paclitaxel second-generation DES in up to 5 years follow-up. DCB is a safe option for the treatment of de novo coronary artery disease.
Choroidal evaluation in patients under alpha-lytic therapy
Authors: De Bernardo Maddalena , Altieri Vincenzo , Coppola Alessia , Gioia Marco , Rosa Nicola 
Published: September 2020

Abstract
Purpose
To detect any choroidal thickness (CT) change in patients after alpha-lytic drugs withdrawal that could help in the cataract surgery timing decision.

Methods
Twenty-five eyes of 25 patients (mean age: 76 ± 7 years) under alpha-lytic therapy, and 25 eyes of 25 control subjects (CS) (mean age: 75 ± 7 years) without alpha-lytic therapy, both scheduled for cataract surgery in the fellow eye, were included in this observational, prospective, non-randomized study. All patients underwent EDI-OCT during the first preoperative visit and approximately 1 month (range 28–31 days) after alpha-lytic withdrawal. In the CS group, the OCT during preoperative visit and approximately 1 month after (range 28–31 days) the first examination was performed. Data normality with Kolmogorov-Smirnov test was checked and statistical evaluation with the Wilcoxon-signed rank test was performed.

Results
The mean subfoveal CT was 224 ± 79.7 μm during therapy and 217 ± 70.4 μm after withdrawal; 1.5 mm nasally from the fovea CT was 198 ± 83.8 μm and 194 ± 82.8 μm, respectively; and 1.5 mm temporally from the fovea CT was 217 ± 55.9 μm and 205 ± 54.4 μm, respectively. A statistically significant reduction (p < 0.05) in all the 3 measured CT points was found. In the CS no significant changes were detected (p > 0.05).

Conclusion
No severe floppy iris syndrome was detected at the time of surgery. In these patients, CT decrease could be an important sign for cataract surgery timing decision.
Water immersion methods do not alter muscle damage and inflammation biomarkers after high-intensity sprinting and jumping exercise
Authors: Ahokas E. K. , Kyröläinen H. , Mero A. A. , Walker S. , Hanstock H. G. , Ihalainen J. K. 
Published: September 2020

Abstract
Purpose
The aim of this study was to compare the efficacy of three water immersion interventions performed after active recovery compared to active recovery only on the resolution of inflammation and markers of muscle damage post-exercise.

Methods
Nine physically active men (n = 9; age 20‒35 years) performed an intensive loading protocol, including maximal jumps and sprinting on four occasions. After each trial, one of three recovery interventions (10 min duration) was used in a random order: cold-water immersion (CWI, 10 °C), thermoneutral water immersion (TWI, 24 °C), contrast water therapy (CWT, alternately 10 °C and 38 °C). All of these methods were performed after an active recovery (10 min bicycle ergometer), and were compared to active recovery only (ACT). 5 min, 1, 24, 48, and 96 h after exercise bouts, immune response and recovery were assessed through leukocyte subsets, monocyte chemoattractant protein-1, myoglobin and high-sensitivity C-reactive protein concentrations.

Results
Significant changes in all blood markers occurred at post-loading (p < 0.05), but there were no significant differences observed in the recovery between methods. However, retrospective analysis revealed significant trial-order effects for myoglobin and neutrophils (p < 0.01). Only lymphocytes displayed satisfactory reliability in the exercise response, with intraclass correlation coefficient > 0.5.

Conclusions
The recovery methods did not affect the resolution of inflammatory and immune responses after high-intensity sprinting and jumping exercise. It is notable that the biomarker responses were variable within individuals. Thus, the lack of differences between recovery methods may have been influenced by the reliability of exercise-induced biomarker responses.
Benefits of insect colours: a review from social insect studies
Authors: Badejo Oluwatobi , Skaldina Oksana , Gilev Aleksei , Sorvari Jouni 
Published: September 2020

AbstractInsect colours assist in body protection, signalling, and physiological adaptations. Colours also convey multiple channels of information. These channels are valuable for species identification, distinguishing individual quality, and revealing ecological or evolutionary aspects of animals’ life. During recent years, the emerging interest in colour research has been raised in social hymenopterans such as ants, wasps, and bees. These insects provide important ecosystem services and many of those are model research organisms. Here we review benefits that various colour types give to social insects, summarize practical applications, and highlight further directions. Ants might use colours principally for camouflage, however the evolutionary function of colour in ants needs more attention; in case of melanin colouration there is evidence for its interrelation with thermoregulation and pathogen resistance. Colours in wasps and bees have confirmed linkages to thermoregulation, which is increasingly important in face of global climate change. Besides wasps use colours for various types of signalling. Colour variations of well chemically defended social insects are the mimetic model for unprotected organisms. Despite recent progress in molecular identification of species, colour variations are still widely in use for species identification. Therefore, further studies on variability is encouraged. Being closely interconnected with physiological and biochemical processes, insect colouration is a great source for finding new ecological indicators and biomarkers. Due to novel digital imaging techniques, software, and artificial intelligence there are emerging possibilities for new advances in this topic. Further colour research in social insects should consider specific features of sociality.
Laparoscopic skills training: the effects of viewing mode (2D vs. 3D) on skill acquisition and transfer
Authors: Beattie Kirsty L. , Hill Andrew , Horswill Mark S. , Grove Philip M. , Stevenson Andrew R. L. 
Published: September 2020

Abstract
Background
Three-dimensional (3D) visual displays have been suggested to aid laparoscopic skills training by providing the depth cues not present in traditional two-dimensional (2D) displays. However, few studies have robustly investigated the impact of viewing mode (2D vs. 3D) on learning outcomes.

Purpose
To examine how viewing mode (2D vs. 3D) impacts the acquisition and transferability of basic laparoscopic skills by comparing performance between transfer and control groups on a complete proficiency-based training program.

Method
A counterbalanced between-subjects design was employed. Each participant was randomly allocated to one of four groups, comprising two transfer groups (trained in one viewing mode and tested in the alternate mode: the 2D → 3D and 3D → 2D groups) and two control groups (trained and tested in one viewing mode: the 2D → 2D and 3D → 3D groups). Participants completed proficiency-based training in six laparoscopic training tasks. Testing included two further repetitions of all tasks under test conditions. Objective performance measures included the total number of repetitions to reach proficiency, and total performance scores (i.e. time + error penalties across all repetitions) in training and testing.

Results
The groups trained in 3D demonstrated superior training performance (i.e. less time + errors) and took fewer repetitions to reach proficiency than the groups trained in 2D. The groups tested in 3D also demonstrated superior test performance compared to those tested in 2D. However, training mode did not yield significant test differences between the groups tested in 2D (i.e. 2D → 2D vs. 3D → 2D), or between the groups tested in 3D (i.e. 3D → 3D vs. 2D → 3D).

Conclusion
Novices demonstrate superior performance in laparoscopic skills training using a 3D viewing mode compared to 2D. However, this does not necessarily translate to superior performance in subsequent testing or enhanced learning overall. Rather, test performance appears to be dictated by the viewing mode used during testing, not that of prior training.
Length of Barrett’s esophagus in the presence of low-grade dysplasia, high-grade dysplasia, and adenocarcinoma
Authors: Barrie Jenifer , Yanni Fady , Sherif Mohamed , Dube Asha K. , Tamhankar Anand P. 
Published: September 2020

AbstractIntroductionThe identification and follow-up of ultra-short Barrett’s esophagus (BE) is controversial. BE surveillance guidelines emphasize mainly on long-segment BE. However, in practice a substantial proportion of esophageal adenocarcinoma (EAC) are found close to the gastro-esophageal junction (GEJ). Our study aims to chart the length of BE when low-grade dysplasia (LGD), high-grade dysplasia (HGD) and EAC arise in BE.MethodsEndoscopic findings from all cases with a diagnosis of LGD and HGD in BE between June 2014 and June 2019, and 100 consecutive cases of EAC diagnosed between June 2018 and August 2019, were reviewed. Additionally, 438 consecutive gastroscopies were reviewed to identify 100 cases of non-dysplastic BE.Results99 cases of LGD and 61 cases of HGD were reviewed. LGD and HGD when diagnosed, was located in BE ≤ 1 cm in 20% and 18% cases, respectively. LGD and HGD when diagnosed, was located in BE ≤ 3 cm in 48.5% and 40.9% cases, respectively. LGD and HGD when diagnosed in BE ≤ 3 cm was found at index endoscopy in 67% and 42% cases, respectively. Of the 100 cases of EAC, only 23 had concurrent visible BE, with BE higher than the level of EAC in seven. EAC when found, had its proximal extent ≤ 1 cm from GEJ in 22% and ≤ 3 cm from GEJ in 40% cases. Of the 100 non-dysplastic BE, 53% were ≤ 1 cm and 78% were ≤ 3 cm long.ConclusionAlmost 20% of all dysplasia in BE occurs in BE < 1 cm. Over 40% occurs in BE < 3 cm. Similarly, 20% of EAC occurs within 1 cm of GEJ and 40% occur within 3 cm. A majority of dysplasia diagnosed within 3 cm of the GEJ is found on index endoscopy. We propose that all lengths of columnar lined epithelium above the GEJ are recognized as BE and subjected to a thorough biopsy protocol.
A framework for Model-Driven Engineering of resilient software-controlled systems
Authors: Parri Jacopo , Patara Fulvio , Sampietro Samuele , Vicario Enrico 
Published: September 2020

AbstractEmergent paradigms of Industry 4.0 and Industrial Internet of Things expect cyber-physical systems to reliably provide services overcoming disruptions in operative conditions and adapting to changes in architectural and functional requirements. In this paper, we describe a hardware/software framework supporting operation and maintenance of software-controlled systems enhancing resilience by promoting a Model-Driven Engineering (MDE) process to automatically derive structural configurations and failure models from reliability artifacts. Specifically, a reflective architecture developed around digital twins enables representation and control of system Configuration Items properly derived from SysML Block Definition Diagrams, providing support for variation. Besides, a plurality of distributed analytic agents for qualitative evaluation over executable failure models empowers the system with runtime self-assessment and dynamic adaptation capabilities. We describe the framework architecture outlining roles and responsibilities in a System of Systems perspective, providing salient design traits about digital twins and data analytic agents for failure propagation modeling and analysis. We discuss a prototype implementation following the MDE approach, highlighting self-recovery and self-adaptation properties on a real cyber-physical system for vehicle access control to Limited Traffic Zones.
Newly detected mutations in the Meq oncogene and molecular pathotyping of very virulent Marek’s disease herpesvirus in Tunisia
Authors: Lachheb Jihene , Mastour Houssem , Nsiri Jihene , Kaboudi Khaled , Choura Imed , Ammouna Faten , Amara Abdelkader , Ghram Abdeljelil 
Published: September 2020

AbstractMarek's disease (MD) is a contagious avian viral disease that is responsible for large economic losses to farmers. The disease is caused by Marek's disease virus (species Gallid alphaherpesvirus 2), which causes neurological lesions, immune suppression, and tumor proliferation of lymphoid cells that invade a large number of organs and tissues. Despite widespread vaccination, Marek's disease virus (MDV), has shown a continuous increase in its virulence and has acquired the ability to overcome immune responses induced by vaccines. In the present study, the oncogenic serotype MDV-1 was detected by real-time PCR in DNA samples extracted from organs developing tumor infiltrations. Identification of the pathotype based on a 132-bp tandem repeat and sequencing and phylogenetic analysis of the Meq gene and its encoded protein allowed classification of the isolated viruses as "very virulent", with two new and unique mutations in the Meq gene resulting in amino acid substitutions. Sequencing of pp38, vIl-8, UL1 and UL44 genes did not reveal any new mutations that were characteristic of the Tunisian isolates or correlated with virulence. These results raised concerns about the ability of HVT and CVI988 vaccines, which are currently used in Tunisia and other countries, to protect chickens against highly virulent virus strains.
Operieren, Absagen, Verschieben oder Selektionieren?
Authors: Klocker J. , Frech A. , Gratl A. , Thaler M. , Khosravi I. , Liebensteiner M. , Kluckner M. , Hofmann W. , Assadian A. ,   Österreichische Gesellschaft für Gefäßchirurgie (ÖGG), Klocker J. , Kluckner M. , Hofmann W. , Assadian A. 
Published: September 2020

ZusammenfassungGefäßchirurgische Zentren in Österreich (n = 15) wurden Mitte April 2020 mit erklärendem Begleitschreiben des Vorstands der Österreichischen Gesellschaft für Gefäßchirurgie (ÖGG) eingeladen, an einer Onlineumfrage über die Implikationen der COVID-19-Pandemie teilzunehmen. Insgesamt 12 Zentren (80 %) haben den Fragebogen ausgefüllt.Alle Zentren waren mit positiv getesteten Patienten und 75 % auch mit positiv getesteten Mitarbeitern konfrontiert. Deutlich seltener war dies jedoch an den gefäßchirurgischen Abteilungen (positiv getestete Patienten in 25 %/Mitarbeiter in 33 %). Elektive Eingriffe wurden an allen Abteilungen entweder gestoppt (abgesagt oder verschoben) oder selektiv eingeschränkt. Dies betraf u. a. auch symptomfreie Patienten mit Karotisstenose, Aortenaneurysma kleiner 7 cm, peripherem Aneurysma, PAVK im Stadium II nach Fontaine oder Varikose. In allen Zentren wurden weiterhin uneingeschränkt gefäßchirurgische Notfälle behandelt. Uneinheitlich war das Vorgehen bei chronischen Ulzera, chronischer Mesenterialinsuffizienz, symptomfreiem Aortenaneurysma größer 7 cm und in der Shuntchirurgie.Insgesamt war v. a. die zum Zeitpunkt der OP-Verschiebungen unklare Befristung der Maßnahmen problematisch, somit war auch das Risiko der abgesagten bzw. hinausgezögerten Behandlung nicht leicht abschätzbar. Für die Indikationen mit uneinheitlichem Vorgehen sollte unizentrisch und multizentrisch das Ergebnis der Patienten analysiert werden, auch hinsichtlich der mit der Verschiebung assoziierten psychologischen Belastung. Zudem bedürfen auch die aufgrund der COVID-19-Pandemie erfolgten Veränderungen im Alltag einer kritischen Auswertung, auch hinsichtlich demografischer und geografischer Unterschiede. Es ist anzunehmen, dass die Auswirkungen der COVID-19-Pandemie langfristig bedeutsam sind.
Managing forest genetic resources as a strategy to adapt forests to climate change: perceptions of European forest owners and managers
Authors: Vinceti Barbara , Manica Mattia , Lauridsen Nina , Verkerk Pieter Johannes , Lindner Marcus , Fady Bruno 
Published: September 2020

AbstractManaging genetic diversity is of key importance in fostering resilience of forest ecosystems to climate change. We carried out a survey reaching over 200 forest owners and managers from 15 European countries to understand their perceptions of the main threats to forest ecosystems, their knowledge of forest genetic resources (FGR) and their attitude toward actively managing these resources to strengthen the resilience of forest ecosystems to climate change. Respondents perceived pests and diseases to be the top-ranking threats to forests, followed by windstorms and drought, with differences across countries. They stated to be aware of the potential offered by managing FGR and indicated that they paid attention to origin and quality in their choice of planting material. Generally, respondents showed a positive attitude in using forest reproductive material foreign to the planting site, to better match the projected future climate conditions, introducing either a new native tree species or a new non-local genotype of a species already planted (keeping the same species but changing the source of planting material). However, forest reproductive material from local sources was largely preferred over non-local material (both genetically improved and not improved). Forest managers and owners may need to be exposed to more evidence of the potential benefits deriving from active adaptation and mitigation management of FGR before implementing adaptive measures. Also, more efforts should be invested in understanding perceptions and motivations of European forest owners and managers, in order to better tailor advice on optimal measures to counteract the detrimental effects of climate change.
The coverage of cultured meat in the US and UK traditional media, 2013–2019: drivers, sources, and competing narratives
Authors: Painter James , Brennen J. Scott , Kristiansen Silje 
Published: September 2020

Abstract‘Cultured’ meat has attracted a considerable amount of investor and media interest as an early-stage technology. Despite uncertainties about its future impact, news media may be contributing to promissory discourses, by stressing the potential benefits from cultured meat to the environment, health, animal welfare, and feeding a growing population. The results from a content analysis of 255 articles from 12 US and UK traditional media from 2013 to 2019 show that much of the coverage is prompted by the industry sector, whose representatives are also the most quoted. Positive narratives about cultured meat are much more prominent than cautionary ones. Our findings support previous scholarship on other emerging technologies which concluded that with important variations, media treatments are largely positive.
Pollination in the Anthropocene: a Moth Can Learn Ozone-Altered Floral Blends
Authors: Cook Brynn , Haverkamp Alexander , Hansson Bill S. , Roulston T’ai , Lerdau Manuel , Knaden Markus 
Published: September 2020

AbstractInsect pollination is essential to many unmanaged and agricultural systems and as such is a key element in food production. However, floral scents that pollinating insects rely on to locate host plants may be altered by atmospheric oxidants, such as ozone, potentially making these cues less attractive or unrecognizable to foraging insects and decreasing pollinator efficacy. We demonstrate that levels of tropospheric ozone commonly found in many rural areas are sufficient to disrupt the innate attraction of the tobacco hawkmoth Manduca sexta to the odor of one of its preferred flowers, Nicotiana alata. However, we further find that visual navigation together with associative learning can offset this disruption. Foraging moths that initially find an ozone-altered floral scent unattractive can target an artificial flower using visual cues and associate the ozone-altered floral blend with a nectar reward. The ability to learn ozone-altered floral odors may enable pollinators to maintain communication with their co-evolutionary partners and reduce the negative impacts that anthropogenically elevated oxidants may have on plant-pollinator systems.
Diazonium Modification of Inorganic and Organic Fillers for the Design of Robust Composites: A Review
Authors: Sandomierski M. , Voelkel A. 
Published: September 2020

AbstractThis review focuses on fillers modified with diazonium salts and their use in composites. We reviewed scientific publications and presented information about such diazonium-modified fillers as boron nitride, carbon fillers, cellulose, clay, silica, titanium dioxide, and zeolite. The fillers were divided into two groups. The first group includes those that form covalent bonds with the polymer, while the second includes those that do not form them. This review indicates a tremendous impact of filler modification using diazonium salts on the properties of composites. The review presents examples of the impact of filler on such properties as thermal conductivity, thermal stability, and mechanical properties (e.g., interfacial shear strength, compressive strength, flexural strength). The presented review indicates the enormous potential of composites with diazonium-modified fillers in control drug release, antistatic coatings, electrode materials, photocatalysts, bone tissue engineering scaffolds, fuel cell applications, abrasive tools, and electromechanical strain sensor. We hope that this review will help both research groups and industry in choosing fillers for given types of polymers and obtaining composites with even better properties.