bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preimplantation Genetic Testing for Monogenic Kidney Disease
Authors: Snoek Rozemarijn , Stokman Marijn F. , Lichtenbelt Klaske D. , van Tilborg Theodora C. , Simcox Cindy E. , Paulussen Aimée D.C. , Dreesen Jos C.M.F. , van Reekum Franka , Lely A. Titia , Knoers Nine V.A.M. , de Die-Smulders Christine E.M. , van Eerde Albertien M. 
Published: August 2020

Background and objectives
A genetic cause can be identified for an increasing number of pediatric and adult-onset kidney diseases. Preimplantation genetic testing (formerly known as preimplantation genetic diagnostics) is a reproductive technology that helps prospective parents to prevent passing on (a) disease-causing mutation(s) to their offspring. Here, we provide a clinical overview of 25 years of preimplantation genetic testing for monogenic kidney disease in The Netherlands.

Design, setting, participants, & measurements
This is a retrospective cohort study of couples counseled on preimplantation genetic testing for monogenic kidney disease in the national preimplantation genetic testing expert center (Maastricht University Medical Center+) from January 1995 to June 2019. Statistical analysis was performed through chi-squared tests.

Results
In total, 98 couples were counseled regarding preimplantation genetic testing, of whom 53% opted for preimplantation genetic testing. The most frequent indications for referral were autosomal dominant polycystic kidney disease (38%), Alport syndrome (26%), and autosomal recessive polycystic kidney disease (9%). Of couples with at least one preimplantation genetic testing cycle with oocyte retrieval, 65% experienced one or more live births of an unaffected child. Of couples counseled, 38% declined preimplantation genetic testing for various personal and technical reasons.

Conclusions
Referrals, including for adult-onset disease, have increased steadily over the past decade. Though some couples decline preimplantation genetic testing, in the couples who proceed with at least one preimplantation genetic testing cycle, almost two thirds experienced at least one live birth rate.
Meta-analyses of ataluren randomized controlled trials in nonsense mutation Duchenne muscular dystrophy
Authors: Campbell Craig , Barohn Richard J , Bertini Enrico , Chabrol Brigitte , Comi Giacomo Pietro , Darras Basil T , Finkel Richard S , Flanigan Kevin M , Goemans Nathalie , Iannaccone Susan T , Jones Kristi J , Kirschner Janbernd , Mah Jean K , Mathews Katherine D , McDonald Craig M , Mercuri Eugenio , Nevo Yoram , Péréon Yann , Renfroe J Ben , Ryan Monique M , Sampson Jacinda B , Schara Ulrike , Sejersen Thomas , Selby Kathryn , Tulinius Már , Vílchez Juan J , Voit Thomas , Wei Lee-Jen , Wong Brenda L , Elfring Gary , Souza Marcio , McIntosh Joseph , Trifillis Panayiota , Peltz Stuart W , Muntoni Francesco ,   on behalf of the PTC124-GD-007-DMD Study Group,   ACT DMD Study Group,   the Clinical Evaluator Training Groups
Published: August 2020

Aim:
Assess the totality of efficacy evidence for ataluren in patients with nonsense mutation Duchenne muscular dystrophy (nmDMD).
Materials & methods:
Data from the two completed randomized controlled trials (ClinicalTrials.gov: NCT00592553; NCT01826487) of ataluren in nmDMD were combined to examine the intent-to-treat (ITT) populations and two patient subgroups (baseline 6-min walk distance [6MWD] ≥300–<400 or <400 m). Meta-analyses examined 6MWD change from baseline to week 48.
Results:
Statistically significant differences in 6MWD change with ataluren versus placebo were observed across all three meta-analyses. Least-squares mean difference (95% CI): ITT (n = 342), +17.2 (0.2–34.1) m, p = 0.0473; ≥300–<400 m (n = 143), +43.9 (18.2–69.6) m, p = 0.0008; <400 m (n = 216), +27.7 (6.4–49.0) m, p = 0.0109.
Conclusion:
These meta-analyses support previous evidence for ataluren in slowing disease progression versus placebo in patients with nmDMD over 48 weeks. Treatment benefit was most evident in patients with a baseline 6MWD ≥300–<400 m (the ambulatory transition phase), thereby informing future trial design.
Asertive training pada wanita dewasa
Authors: Santoso Dimas Setiawan 
Published: August 2020

Subjek merupakan wanita berumur 20 tahun Subjek kurang dapat mengungkapkan pendapatnya dalam situasi apapun. Selain itu ia juga sulit mengatakan apa yang diinginkannya pada orang lain. Subjek seringkali hanya bisa mengikuti ajakan temannya kemanapun atau melakukan sesuatu walaupun ia merasa itu merugikan dirinya. Asesmen yang digunakan meliputi self report, wawancara, alloanamnesa, SSCT, tes Grafis dan skala asertifitas. Intervensi yang diberikan adalah positive reinforcement yang dirancang sebanyak 6 sesi. Tujuan intervensi ini yaitu agar subjek Mampu mengungkapkan perasaan, menolak, berpendapat kepada teman dikampus. Hasil dari intervensi yang dilakukan adalah assertive training memberikan perngaruh terhadap perubahan perilaku pada subjek yaitu ia mampu untuk mengungkapkan pendapat dan menolak ajakan teman meskipun ia belum sampai pada tahap menjelaskan alasan penolakan tersebut
Glucose as the Fifth Vital Sign: A Randomized Controlled Trial of Continuous Glucose Monitoring in a Non-ICU Hospital Setting
Authors: Fortmann Addie L. , Spierling Bagsic Samantha R. , Talavera Laura , Garcia Isabel Maria , Sandoval Haley , Hottinger Amiry , Philis-Tsimikas Athena 
Published: August 2020

OBJECTIVEThe current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non–intensive care unit (ICU) hospital setting.RESEARCH DESIGN AND METHODSA total of 110 adults with type 2 diabetes on a non-ICU floor received RT-CGM with Dexcom G6 versus usual care (UC). RT-CGM data were wirelessly transmitted from the bedside. Hospital telemetry monitored RT-CGM data and notified bedside nursing of glucose alerts and trends. Standardized protocols were used for interventions.RESULTSThe RT-CGM group demonstrated significantly lower mean glucose (M∆ = −18.5 mg/dL) and percentage of time in hyperglycemia &gt;250 mg/dL (−11.41%) and higher time in range 70–250 mg/dL (+11.26%) compared with UC (P values &lt;0.05). Percentage of time in hypoglycemia was very low.CONCLUSIONSRT-CGM can be used successfully in community-based hospital non-ICU settings to improve glucose management. Continuously streaming glucose readings may truly be the fifth vital sign.
In the Image of Lucifer
Authors: Dash Sakti Sekhar 
Published: August 2020

The image of Judge Holden evokes the image of a sinister seven-foot-tall, completely hairless man, who is the arch-nemesis of humanity. A man of vast erudition, Holden is also the most savage of the lot riding alongside John Joel Glanton. The figure of Judge Holden has drawn comparisons to the character of Captain Ahab and the great white whale, Moby Dick.
But Judge Holden also brings to mind the character of Lucifer. Both of them emerge as enemies of humanity and appear awe-inspiring even in their fallen state. It must not be forgotten that they had possibly glorious pasts. But they made choices that led them to become sinister and malevolent characters. Their depravity and fallen state are in stark contrast with their intellectual refinement. Lucifer features prominently across the myths of different cultures. In most representations, he appears as the “bearer of light.” A celestial figure, close to God, Lucifer becomes a damned and fallen figure, the avowed enemy of humanity.
Curative Fungicide Activity Against Calonectria pseudonaviculata, the Boxwood Blight Pathogen1
Authors: LaMondia J. A. 
Published: August 2020

Abstract
Azoxystrobin, azoxystrobin plus benzovindiflupyr, kresoxim-methyl, propiconazole, pyraclostrobin, pyraclostrobin plus fluxapyroxad, tebuconazole, tetraconazole, thiophanate-methyl, and triflumizole fungicides were evaluated for curative and anti-sporulant activity against boxwood blight caused by Calonectria pseudonaviculata on detached leaves and whole boxwood plants (Buxus spp.). Pretreating detached leaves with 30 or 300 ppm a.i. 24 h prior to inoculation reduced disease compared to the untreated control for all fungicides. Fungicides were also applied 24 to 96 h post-inoculation. Only propiconazole reduced diseased leaf incidence to at least half of the control. When leaves were treated post-infection with 300 ppm propiconazole, tetraconazole, tebuconazole, or triflumizole, the pathogen did not sporulate over 2 wks. Propiconazole also reduced the percent of leaf area diseased; lesions were nearly 80% smaller with 300 ppm applied 48 h after inoculation. ‘True Dwarf' boxwood plants treated with 450 ppm thiophanate-methyl, 120 ppm pyraclostrobin or 150 ppm propiconazole 48 h after inoculation demonstrated that only propiconazole reduced the number of diseased leaves, blight lesions and the frequency of pathogen re-isolation. Experiments with ‘Green Mound' and ‘Green Mountain' boxwood cultivars and additional fungicides applied 48 h after inoculation demonstrated that propiconazole at 300 ppm, pyraclostrobin plus fluxapyroxad (150 ppm each) and azoxystrobin (135 ppm) plus benzovindiflupyr (67.5 ppm) reduced disease.
Index words: fungicide management, Buxus, chemical disease management
Chemicals used in this study: azoxystrobin (Heritage 50 WG), azoxystrobin plus benzovindiflupyr (Mural 30, 50 WG), kresoxim-methyl (Cygnus 50 WG), propiconazole (ProCon-Z 14.3 L), pyraclostrobin (Insignia 20 WG), pyraclostrobin plus fluxapyroxad (Orkestra Intrinsic 21.26 SC), tebuconazole (Torque 38.7 SC), tetraconazole (Minerva 11.6 SC), thiophanate-methyl (3336 50% WP), triflumizole (Procure 480 SC).
Species used in this study: boxwood (Buxus L.), boxwood blight (Calonectria pseudonaviculata (Crous, J.Z. Groenew. & C.F. Hill) L. Lombard, M. J. Wingf. & Crous.
Operational Accounting: Transformation in the Digital Economy
Authors: Demina I. D. , Polulekh M. V. 
Published: August 2020

The research of the operational accounting problem is particularly relevant in the light of the large-scale tasks implementation for the digitalization of the economy, since its maintenance provides highlighting of production chains and economic operations. So far, this accounting does not have a solid theoretical and methodological basis, which complicates the development of specific recommendations for its formulation. The methodological framework of the study includes the theory and concept of operational accounting. There was carried out a retrospective analysis of theoretical and methodological provisions was carried out on that basis. The managerial essence of operational accounting and its specific character in Russian conditions — the planned beginning have been proved. The paper shows the necessity of refinement of the concept, adapted to the requirements of counter-planning and monitoring. The theoretical and practical significance of the research lies in the development of theoretical and methodological provisions of operational accounting. All this improves the organizational level of internal and external control over typical business processes of domestic production by establishing their relationship. This work can be of interest to government agencies when forming and implementing a national strategy for economic development.
Design Pembelajaran Matematika Dengan Pendekatan Stem (Science, Technology, Engineering, Mathematics)
Authors: Susanti Eva , Kurniawan Haris 
Published: August 2020

Penelitian ini bertujuan untuk menghasilkan lintasan belajar siswa pada materi pelajaran matematika pola bilangan berdasarkan pembelajaran Project Based Learning (PjBL) dengan pendekatan STEM (science, Technology, Engineering, mathematics). Penelitian ini merupakan penelitian design research yang terdiri dari tiga tahapan, yaitu : preliminary design, design experiment, retrospective analysis. Subjek penelitian terdiri dari 32 siswa kelas VIII.7 SMP Negeri 27 Palembang. Pengumpulan data dilakukan menggunakan lembar observasi, wawancara, rekaman video, foto, dan lembar aktivitas siswa. Semua data dikumpulkan dan dianalisis secara retrospective yang beracuan pada HLT (Hypothetical Learning Trajectory). Hasil analisis data menyimpulkan bahwa peneltian ini telah menghasilkan lintasan belajar materi pola bilangan kelas VIII yang valid dan reliable. Validitas tergambar dari HLT dan trackability. Dan reabilitas dilihat dari triangulasi data yang dilihat dari catatan lapangan, lembar observasi, dan rekaman video. Dari hasil analisis data disimpulkan bahwa lintasan belajar materi pola bilangan model pembelajaran PjBL pendekatan STEM membuat aktivitas pembelajaran siswa lebih aktif dan antusias, mengajak siswa untuk kreatif dalam berkreasi, aktif dalam berdiskusi, dan siswa memiliki kemampuan komunikasi presentasi atas hasil kerja kelompoknya menyelesaikan tugas proyek.
Zofia Dwornik: Becoming a Female Film Editor
Authors: Kwiatkowska Paulina 
Published: August 2020

In this article the author intends to recall the figure of Zofia Dwornik, one of the most appreciated and nowadays rather forgotten female film editors of post-war communist Poland. For the twenty-five years of her creative activity, Dwornik cooperated in the production of more than thirty films with the most important directors of the Polish cinema in the 1950s, 60s and 70s. In the Polish post-war cinema, the profession of film editor was strongly feminised. In the case of Dwornik, her decision to choose this particular profession was, however, based on additional objective considerations, closely related to the context of the Stalinist period in Poland, and was not her first choice of career – she had wanted to become a film director. In this article the author takes a closer look not so much at the achievements of Dwornik in the 1960s and 70s, but at the complex circumstances that influenced her later career. Therefore, the author tries to reconstruct the most important moments in Dwornik’s student and professional life in the first years after WWII and analyse one of the film études she made at the Film School in Łódź, in order to examine the reasons for her decision to become a film editor. This allows also to formulate some hypotheses how her career might have developed, had she been given the chance to graduate and try her hand at directing.
Éminence Grise or a Mentor? More on Ester Krumbachová
Authors: Świętochowska Grażyna 
Published: August 2020

A graduate of painting and graphic arts at the Higher School of Arts and Crafts in Brno, Ester Krumbachová became known in her professional life as a costume designer, set designer, scriptwriter, author and finally a director. However, she was often pushed to the margins of authorship with the label of “inspiration and just a muse”. There are at least a few basic themes that organize the specificity of Ester’s artistic discourse. There are costumes, and props for which she was responsible: hats, shawls, black umbrellas, silk shirts, camp coats or overalls made out of newspaper and twine. But the whole galaxy of food, meal preparation, feeding and gluttony demands describing. The films Ester was involved in, as a writer or director, are woven from it. The specificity of the interior, often adjacent to the “metaphorical and mental” map of the artist’s apartment, becomes an important background for the platform of culinary images. The recorded registers seem to speak of food and clothes, typically female areas of interest and activity. The main aim of this article will be to treat them as semantically important mechanisms of communication, mostly visual and non-verbal.
Actividades docentes en las instituciones de educación superior basadas en la teoría psicológica de la asimilación del material educativo por parte del estudiante
Authors: Mikhailovna Kolomietsv Olga , Yurievna Karpova Olga , Akopovna Kondakchyan Natalia , Vasilievna Matienko Inna 
Published: August 2020

El artículo está dedicado al descubrimiento de la esencia de la actividad docente y las condiciones de su organización en el contexto de la teoría psicológica de la asimilación de la experiencia social, lo que garantiza que cada estudiante logre un alto nivel de resultados educativos. La propuesta que se presenta en dicho trabajo surgió a partir del estudio piloto, que se realizó durante siete años como capacitación avanzada para docentes de medicina en el programa profesional adicional “Desarrollo de actividades de enseñanza docente” en la Primera Universidad Médica Estatal de Moscú Sechenov. Lo importante del modelo descrito y donde radica su universalidad es que es aplicable a las actividades docentes en cualquier rama de saber. La novedad del trabajo consiste en la descripción de un modelo de actividad docente que implementa dos procesos psicológicos consecutivos de interiorización y exteriorización que conforman el proceso de asimilación. Se revelan la estructura y el contenido de los cuatro tipos de actividades del profesor en la enseñanza, las tecnologías, los métodos, los medios y las formas de su organización en el proceso educativo de acuerdo con la naturaleza psicológica de la actividad de asimilar la experiencia social por parte del sujeto. Se presentan innovadores materiales didácticos para el profesor y el educando que proporcionan una dirección eficaz de las actividades educativas y profesionales de cada estudiante, implementando los procesos psicológicos de interiorización y exteriorización.
La enseñanza de lenguas extranjeras fuera del entorno lingüístico: sugerencias metodológicas
Authors: Iakovleva Svetlana 
Published: August 2020

El presente artículo trata sobre la problemática de la enseñanza de lenguas extranjeras (LE) en condiciones de fuera del entorno lingüístico a los mexicanos cuya profesión futura no está relacionada con lenguas. Se analiza la situación actual en cuanto a la composición del personal académico, los materiales didácticos y las características específicas de este tipo de alumnado. Se postula el método del comentar didáctico lingüístico y extra lingüístico como un método que podría dar solución inmediata a varios problemas relacionados con el proceso de enseñanza-aprendizaje de LE y se ofrecen sugerencias metodológicas de cómo aplicar este método en la enseñanza de lenguas extranjeras.
QUALITY OF EDUCATION IN THE UNIVERSITY OF EASTERN PHILIPPINES: STAKEHOLDERS’ VIEW
Authors: U. Flores Jr. Abel Alejandro 
Published: August 2020

This study focused on the stakeholders’ views on quality higher education in the University of Eastern Philippines. Specifically, it explored and analyzed the processes involved in the crafting of the institution’s strategic plan in terms of its vision and mission statements; identified the quality assurance policies of the University; and, documented the performance of its graduates in terms of passing government licensure examinations.
A mixed form of research technique was used as the research design, utilizing 384 randomly selected respondents composed of students, faculty members, alumni, and community stakeholders. Also included as respondents were the Vice Presidents, College Deans, and 3 other University officials, thus, the total number of respondents was 400 individuals. The mean was used to determine and compare the responses of the various stakeholder groups.
Generally, the respondents were aware of the institution’s strategic plan, but many of them found it difficult to memorize its mission statement. Consultations were made, though not with all stakeholders, during the crafting of the strategic plan. They also noted that policies and guidelines were established, implemented, and strictly adhered to by the administration in its daily operations.
Over a six-year period (2009 – 2014), the institution and its graduates generally performed below the national mean in its performance in government licensure examinations, although it has consistently performed well in examinations for Nurses, Elementary and Secondary Teachers, Master Electricians, and Criminologists.
The institution therefore, has a well-crafted strategic plan, has established policies and guidelines for program implementation, and utilizes varied processes to ensure sustainability of educational programs. It is noted however, that performance of its graduates was generally lower than the national average.
The Effect of Core Learning Model on Students’ Metacognitive Skills in Lipid Material
Authors: Antika Rindi Novitri 
Published: August 2020

Metacognitive is one of the important factors must have by student. This study aims to determine the effect of the CORE (Connecting, Organizing, Reflecting, and Extending) learning model on students' metacognitive sklills and find out the students' responses about it’s implementation. This research is a pre-experimental study with one group pretest-posttest design. The subject of this study was grade 3rd of biology education students. The instrument in this study is an essay and metacognition descriptor rubric to assess students' metacognitive skill, then questionnaires to obtain data on student responses that implemented the CORE learning model. Based on the results of the paired sample t test on student metacognition scores obtained sig. 0.00 <0.05, it means that there are differences between the results of the student's pretest and posttest. Then, based on N-gain analysis pretest and posttest data, it is known that the N-gain value is 0.71, it’s means high increase category,. Then the result of pearson correlation test to analyze correlation between cognitive learning outcomes and student metacognitive skills obtained sig. 0,00, it means that there was a correlation between the two of them. Based on some of these analyzesit can be concluded that the CORE learning model influences students' metacognitive skills on lipid material. This was supported by the results of a questionnaire showed that students gave positive responses about the application of the CORE learning model, it was known from questionnaire data, more than 85% of students felt the CORE model had a positive impact on learning.
Use of chlorhexidine 0.2% gel to prevent alveolar osteitis in mandibular third molar surgical extraction.
Authors: Hamid Shuja , Memon Mahwish , Ali Raza , Shams Salman 
Published: August 2020

Objectives: To evaluate the efficacy of 0.2% chlorhexidine gel placed intra alveolar in the prevention of alveolar osteitis after the surgical extraction of mandibular third molar. Study Design: Randomized Control trial. Setting: Department of Oral and Maxillofacial Surgery, LUMHS, Jamshoro/Hyderabad. Period: January 2016 to July 2016. Material & Methods: This study consisted of 40 patients in control group A and 40 patients of Chlorohexidine gel group B used after surgical extraction. A single dose of 0.2% bio-adhesive gel was introduced in group B while the control group A was left alone. Postoperative complications like pain, swelling, limited mouth opening, and dry socket were seen. Frequency and percentages were calculated. Mean +/- SD were calculated for quantitative variables. Results: On 3rd day patients reported with pain in group A were 24 and in group B were 15. Pain was seen in 4 patients (10%) on 15th day in group A while in group B no patient came with pain. 19 patients reported with dry socket on day 3 in group A and 4 patients in group B, While none of the patient encountered with Dry socket on 15th day in group in both groups. Conclusion: The data presented indicates that the bio-adhesive gel containing 0.2% chlorohexidine, applied post-extraction produced a better patient recovery.