bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photosystem II antenna complexes CP26 and CP29 are essential for nonphotochemical quenching in Chlamydomonas reinhardtii
Authors: Cazzaniga Stefano , Kim Minjae , Bellamoli Francesco , Jeong Jooyoen , Lee Sangmuk , Perozeni Federico , Pompa Andrea , Jin EonSeon , Ballottari Matteo 
Published: November 2019

AbstractPhotosystems must balance between light harvesting to fuel the photosynthetic process for CO2 fixation and mitigating the risk of photodamage due to absorption of light energy in excess. Eukaryotic photosynthetic organisms evolved an array of pigment‐binding proteins called light harvesting complexes constituting the external antenna system in the photosystems, where both light harvesting and activation of photoprotective mechanisms occur. In this work, the balancing role of CP29 and CP26 photosystem II antenna subunits was investigated in Chlamydomonas reinhardtii using CRISPR‐Cas9 technology to obtain single and double mutants depleted of monomeric antennas. Absence of CP26 and CP29 impaired both photosynthetic efficiency and photoprotection: Excitation energy transfer from external antenna to reaction centre was reduced, and state transitions were completely impaired. Moreover, differently from higher plants, photosystem II monomeric antenna proteins resulted to be essential for photoprotective thermal dissipation of excitation energy by nonphotochemical quenching.
Flattening Hierarchies. SLI as a Window onto the Architecture of Language
Authors: Lorenzo Guillermo , Vares Elena 
Published: November 2019

AbstractChildren with SLI have traditionally been diagnosed as exhibiting core deficits affecting their phonological and morphological performance. These well‐known aspects of SLI, at least, thus appear to refer the syndrome to the Externalization component of the Faculty of Language. If such a conclusion is on the right track, then it could be predicted that Linearization, also an aspect of Externalization according to the Minimalist architecture of the Faculty of Language, should also be a typical locus of affectation in cases of SLI. This paper presents and interprets data regarding comprehension and production phenomena of a population of Spanish‐speaking children with SLI. These data support the aforementioned prediction, thus reinforcing the design specifications that the Minimalist Program attributes to language capacity.
Ex vivo comparison of barbed sutures for pelvic flexure enterotomy in horses
Authors: Sinovich Matthew , Archer Debbie C. , Meunier Natascha V. , Kelly Padraig G. 
Published: November 2019

AbstractObjectiveTo evaluate two different barbed sutures for closure of pelvic flexure enterotomies and compare results achieved with two previously described closure techniques.Study designEx vivo.Sample populationTwenty‐four fresh cadaver adult equine large colons.MethodsCadavers were randomly assigned to four closure groups (n = 6 each group): single‐layer absorbable suture, double‐layer absorbable suture, single‐layer unidirectional barbed suture, or single‐layer bidirectional barbed suture. Construction time, luminal reduction (percentage), bursting pressure, and method of failure were measured. Cost, leakage, exposed suture, and general appearance were recorded. Comparisons were performed with one‐way analysis of variance and post hoc Bonferroni test (P < .05).ResultsDouble‐layer absorbable closure had the highest bursting pressure (mean = 178.5 mm Hg, SD = 9.79, P < .001) but took more time (P = .001) compared with all other groups. The construction time of both barbed suture closures did not differ from the single‐layer closure (P > .06). Bursting strengths of both unidirectional (mean = 91.6 mm Hg, SD = 5.57) and bidirectional (mean = 87.5 mm Hg, SD = 8.69) barbed sutures were lower (P > .006 for both) than those of both single‐ (mean = 117.6 mm Hg, SD = 11.69) and double‐layer (mean = 178.5 mm Hg, SD = 9.79) closures. Unidirectional barbed suture closure had a reduction in lumen diameter (P = .004) compared with bidirectional and single‐layer closures.ConclusionEnterotomy closures with the two different barbed suture patterns were comparable in bursting strength and construction time. However, the barbed suture patterns had lower bursting strength compared with traditional single‐ and double‐layer closures. Unidirectional barbed suture closure also reduced lumen diameter.Clinical significanceClosure of a large colon enterotomy with barbed suture patterns may be less secure than single‐ and double‐layer suture closure.
MORAL ORTHOSES: A NEW APPROACH TO HUMAN AND MACHINE ETHICS
Authors: Dorobantu Marius , Wilks Yorick 
Published: November 2019

AbstractMachines are increasingly involved in decisions with ethical implications, which require ethical explanations. Current machine learning algorithms are ethically inscrutable, but not in a way very different from human behavior. This article looks at the role of rationality and reasoning in traditional ethical thought and in artificial intelligence, emphasizing the need for some explainability of actions. It then explores Neil Lawrence's embodiment factor as an insightful way of looking at the differences between human and machine intelligence, connecting it to the theological understanding of embodiment, relationality, and personhood. Finally, it proposes the notion of artificial moral orthoses, which could provide ethical explanations for both artificial and human agents, as a more promising unifying approach to human and machine ethics.
Simultaneous Interpretation of Three-Phase Relative Permeability and Capillary Pressure for a Tight Carbonate Reservoir From Wireline Formation Testing
Authors: Liu Xiangnan , Yang Daoyong 
Published: November 2019

AbstractIn this paper, techniques have been developed to interpret three-phase relative permeability and water–oil capillary pressure simultaneously in a tight carbonate reservoir from numerically simulating wireline formation tester (WFT) measurements. A high-resolution cylindrical near-wellbore model is built based on a set of pressures and flow rates collected by dual packer WFT in a tight carbonate reservoir. The grid quality is validated, the effective thickness of the WFT measurements is examined, and the effectiveness of the techniques is confirmed prior to performing history matching for both the measured pressure drawdown and buildup profiles. Water–oil relative permeability, oil–gas relative permeability, and water–oil capillary pressure are interpreted based on power-law functions and under the assumption of a water-wet reservoir and an oil-wet reservoir, respectively. Subsequently, three-phase relative permeability for the oil phase is determined using the modified Stone II model. Both the relative permeability and the capillary pressure of a water–oil system interpreted under an oil-wet condition match well with the measured relative permeability and capillary pressure of a similar reservoir rock type collected from the literature, while the relative permeability of an oil–gas system and the three-phase relative permeability bear a relatively high uncertainty. Not only is the reservoir determined as oil-wet but also the initial oil saturation is found to impose an impact on the interpreted water relative permeability under an oil-wet condition. Changes in water and oil viscosities and mud filtrate invasion depth affect the range of the movable fluid saturation of the interpreted water–oil relative permeabilities.
Impact of Fluid Substitution on the Performance of an Axial Compressor Blade Cascade Working with Supercritical Carbon Dioxide
Authors: Tello Carlos , Muñoz Alejandro , Sánchez David , Kipouros Timoleon , Savill Mark 
Published: November 2019

Abstract
Recent research on turbomachinery design and analysis for supercritical carbon dioxide (sCO2) power cycles has relied on computational fluid dynamics. This has produced a large number of works whose approach is mostly case-specific, rather than of general application to sCO2 turbomachinery design. As opposed to such approach, this work explores the aerodynamic performance of compressor blade cascades operating on air and supercritical CO2 with the main objective to evaluate the usual aerodynamic parameters of the cascade for variable boundary conditions and geometries, enabling “full” or “partial” similarity. The results present both the global performance of the cascades and certain features of the local flow (trailing edge and wake). The discussion also highlights the mechanical limitations of the analysis (forces exerted on the blades), which is the main restriction for applying similarity laws to extrapolate the experience gained through decades of work on air turbomachinery to the new working fluid. This approach is a step toward the understanding and appropriate formulation of a multi-objective optimization problem for the design of such turbomachinery components where sCO2 is used as the operating fluid. With this objective, the paper aims to identify and analyze what would be expected if a common description of such computational design problems similar to those where air is the working fluid were used.
miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy
Authors: Xu Wen-Ping , Liu Jin-Pei , Feng Ji-Feng , Zhu Chang-Peng , Yang Yuan , Zhou Wei-Ping , Ding Jin , Huang Chen-Kai , Cui Ya-Lu , Ding Chen-Hong , Zhang Xin , Lu Bin , Xie Wei-Fen 
Published: November 2019

ObjectiveAutophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated the feasibility of sensitising HCC cells to sorafenib by modulating miR-541-initiated microRNA-autophagy axis.DesignGain- and loss-of-function assays were performed to evaluate the effects of miR-541 on the malignant properties and autophagy of human HCC cells. Autophagy was quantified by western blotting of LC3, transmission electron microscopy analyses and confocal microscopy scanning of mRFP-GFP-LC3 reporter construct. Luciferase reporter assays were conducted to confirm the targets of miR-541. HCC xenograft tumours were established to analyse the role of miR-541 in sorafenib-induced lethality.ResultsThe expression of miR-541 was downregulated in human HCC tissues and was associated with malignant clinicopathologic phenotypes, recurrence and survival of patients with HCC. miR-541 inhibited the growth, metastasis and autophagy of HCC cells both in vitro and in vivo. Prediction software and luciferase reporter assays identified autophagy-related gene 2A (ATG2A) and Ras-related protein Rab-1B (RAB1B) as the direct targets of miR-541. Consistent with the effects of the miR-541 mimic, inhibition of ATG2A or RAB1B suppressed the malignant phenotypes and autophagy of HCC cells. Furthermore, siATG2A and siRAB1B partially reversed the enhancement of the malignant properties and autophagy in HCC cells mediated by the miR-541 inhibitor. More interestingly, higher miR-541 expression predicted a better response to sorafenib treatment, and the combination of miR-541 and sorafenib further suppressed the growth of HCC cells in vivo compared with the single treatment.ConclusionsDysregulation of miR-541-ATG2A/RAB1B axis plays a critical role in patients’ responses to sorafenib treatment. Manipulation of this axis might benefit survival of patients with HCC, especially in the context of the highly pursued strategies to eliminate drug resistance.
Constraining the Inert Doublet Model using Vector Boson Fusion
Authors: Dercks Daniel , Robens Tania 
Published: November 2019

AbstractIn this work, we use a recast of the Run II search for invisible Higgs decays within Vector Boson Fusion to constrain the parameter space of the Inert Doublet model, a two Higgs doublet model with a dark matter candidate. When including all known theoretical as well as collider constraints, we find that the above can rule out a relatively large part in the $$m_H,\,\lambda _{345}$$mH,λ345 parameter space, for dark scalar masses $$m_H\,\le \,100\,{\mathrm{GeV}}$$mH≤100GeV. Including the latest dark matter constraints, a smaller part of parameter space remains which is solely excluded from the above analysis. We also discuss the sensitivity of monojet searches and multilepton final states from Run II.
Malware Dynamic Analysis Evasion Techniques
Authors: Afianian Amir , Niksefat Salman , Sadeghiyan Babak , Baptiste David 
Published: November 2019

The cyber world is plagued with ever-evolving malware that readily infiltrate all defense mechanisms, operate viciously unbeknownst to the user, and surreptitiously exfiltrate sensitive data. Understanding the inner workings of such malware provides a leverage to effectively combat them. This understanding is pursued often through dynamic analysis which is conducted manually or automatically. Malware authors accordingly, have devised and advanced evasion techniques to thwart or evade these analyses. In this article, we present a comprehensive survey on malware dynamic analysis evasion techniques. In addition, we propose a detailed classification of these techniques and further demonstrate how their efficacy holds against different types of detection and analysis approaches.
Our observations attest that evasive behavior is mostly concerned with detecting and evading sandboxes. The primary tactic of such malware we argue is fingerprinting followed by new trends for reverse Turing test tactic which aims at detecting human interaction. Furthermore, we will posit that the current defensive strategies, beginning with reactive methods to endeavors for more transparent analysis systems, are readily foiled by zero-day fingerprinting techniques or other evasion tactics such as stalling. Accordingly, we would recommend the pursuit of more generic defensive strategies with an emphasis on path exploration techniques that has the potential to thwart all the evasive tactics.
Arrhythmia Mechanisms and Outcomes of Ablation in Pediatric Patients With Congenital Heart Disease
Authors: Houck Charlotte A. , Chandler Stephanie F. , Bogers Ad J.J.C. , Triedman John K. , Walsh Edward P. , de Groot Natasja M.S. , Abrams Dominic J. 
Published: November 2019

Background:
In contrast to the adult population with congenital heart disease (CHD), arrhythmia mechanisms and outcomes of ablation in pediatric patients with CHD in recent era have not been studied in detail. Aims of this study were to determine arrhythmia mechanisms and to evaluate procedural and long-term outcomes in pediatric patients with CHD undergoing catheter ablation.

Methods:
Consecutive patients <18 years of age with CHD undergoing catheter ablation over an 11-year period (2007–2018) were included. Procedural outcome included complete or partial success, failure or empirical ablation. Long-term outcome included arrhythmia recurrence and burden according to a 12-point clinical arrhythmia severity score.

Results:

The study population consisted of 232 patients (11.7 years [0.01–17.8], 33.5 kg [2.2–130.1]). The most common diagnoses were Ebstein’s anomaly (n=44), septal defects (n=39), and single ventricle (n=36). Arrhythmia mechanisms included atrioventricular reentry tachycardia (n=104, 90 patients), atrioventricular nodal reentry tachycardia (n=33, 29 patients), twin atrioventricular nodal tachycardia (n=3, 2 patients), macroreentrant atrial tachycardia (n=59, 56 patients), focal atrial tachycardia (n=33, 25 patients), ventricular ectopy (n=10, 8 patients), and ventricular tachycardia (n=15, 13 patients). Fifty-six arrhythmias (39 patients) were undefined. Outcomes included complete success (n=189, 81%), partial success (n=7, 3%), failure (n=16, 7%), or empirical ablation (n=20, 9%). Over 3.6 years (0.3–10.7) arrhythmia recurred in 49%. Independent of arrhythmia recurrence, arrhythmia scores decreased from 4 (0–10) at baseline to 0.5 (0–8) at 4 years follow-up (
P
<0.001). In 23/51 repeat procedures (45%), a different arrhythmia substrate was found. Overall adverse event rate was 9.4%, although only 1.6% (n=4) were of major severity and 0.8% (n=2) of moderate severity.

Conclusions:
Pediatric patients with CHD demonstrate a broad spectrum of arrhythmia mechanisms. Despite recurrence and emergence of novel mechanisms after a successful procedure, ablation can be performed safely and successfully resulting in decreased arrhythmia burden.
Rethinking Cultural Evolutionary Psychology
Authors: Nichols Ryan , Moll Henrike , Mackey Jacob L. 
Published: November 2019

AbstractThis essay discusses Cecilia Heyes’ groundbreaking new book Cognitive Gadgets: The Cultural Evolution of Thinking. Heyes’ point of departure is the claim that current theories of cultural evolution fail adequately to make a place for the mind. Heyes articulates a cognitive psychology of cultural evolution by explaining how eponymous “cognitive gadgets,” such as imitation, mindreading and language, mental technologies, are “tuned” and “assembled” through social interaction and cultural learning. After recapitulating her explanations for the cultural and psychological origins of these gadgets, we turn to criticisms. Among those, we find Heyes’ use of evolutionary theory confusing on several points of importance; alternative theories of cultural evolution, especially those of the Tomasello group and of Boyd, Richerson and Henrich, are misrepresented; the book neglects joint attention and other forms of intersubjectivity in its explanation of the origins of cognitive gadgets; and, whereas Heyes accuses other theories of being “mindblind,” we find her theory ironically other-blind and autistic in character.
The Technological Utopia: Mimamori Care and Family Separation in Japan
Authors: van der Veere Anoma P. 
Published: November 2019

Abstract
Japan is undergoing a significant demographic upheaval, and the Japanese government is formulating policies for stimulating technological advances based on the assumption that they will solve issues such as labour shortages and elder care. The government argues through policy initiatives that technology will decrease the care burden on Japan’s workers, families, and itself. Although the domestic media show awareness of changing family patterns in Japan, newspapers are following a similar pattern of technological utopianism. However, this article posits that the proposed policy reforms rely on a conservative ideal of the extended family that ignores changing patterns in Japanese households. Moreover, it argues that, rather than facilitating a return to the ideal of an extended family, technology is exacerbating separation among families that have been growing apart for some time.
Cell Phone City: Reinventing Tokyo’s Urban Space for Social Use
Authors: Sneep Deirdre 
Published: November 2019

Abstract
Although the growth of the mobile internet is a global phenomenon, several urban agglomerations are in East Asian countries that rank particularly high in mobile internet use. Among them is Tokyo, the cradle of mobile internet technology. The constant connectedness to the internet transforms the city and its communities, making them interesting case studies for research on smart communities. In line with Goggin and McLelland’s 2017 call for a more localized perspective on (mobile) internet use, this article critically re-visits the existing theoretical framework on how virtual space influences the city, and it compares findings with anthropological fieldwork the author conducted in Tokyo. The article looks at how mobile phones can be used to interact with established contacts over a distance, connect strangers by forming ‘mobile phone hubs’, and even disconnect the user when the device is used to ‘shield’ oneself from those in the vicinity.
The Vertical Structure of Open-Ocean Submesoscale Variability during a Full Seasonal Cycle
Authors: Erickson Zachary K. , Thompson Andrew F. , Callies Jörn , Yu Xiaolong , Garabato Alberto Naveira , Klein Patrice 
Published: November 2019

AbstractSubmesoscale dynamics are typically intensified at boundaries and assumed to weaken below the mixed layer in the open ocean. Here, we assess both the seasonality and the vertical distribution of submesoscale motions in an open-ocean region of the northeast Atlantic. Second-order structure functions, or variance in properties separated by distance, are calculated from submesoscale-resolving ocean glider and mooring observations, as well as a 1/48° numerical ocean model. This dataset combines a temporal coverage that extends through a full seasonal cycle, a horizontal resolution that captures spatial scales as small as 1 km, and vertical sampling that provides near-continuous coverage over the upper 1000 m. While kinetic and potential energies undergo a seasonal cycle, being largest during the winter, structure function slopes, influenced by dynamical characteristics, do not exhibit a strong seasonality. Furthermore, structure function slopes show weak vertical variations; there is not a strong change in properties across the base of the mixed layer. Additionally, we compare the observations to output from a high-resolution numerical model. The model does not represent variability associated with superinertial motions and does not capture an observed reduction in submesoscale kinetic energy that occurs throughout the water column in spring. Overall, these results suggest that the transfer of mixed layer submesoscale variability down to depths below the traditionally defined mixed layer is important throughout the weakly stratified subpolar mode waters.
The American Democratic Deficit in Assisted Reproductive Technology Innovation
Authors: Lewis Myrisha S. 
Published: November 2019

In many areas of innovation, the United States is a leader, but this characterization does not apply to the United States' position in assisted reproductive technology innovation and clinical use. This article uses a political science concept, the idea of the “democratic deficit” to examine the lack of American public discourse on innovations in ART. In doing so, the article focuses on America's missing public consultation in health care innovation. This missing discourse is significant, as political and ethical considerations may impact regulatory decisions. Thus, to the extent that these considerations are influencing the decisions of federal agency employees, namely those who work within the U.S. Food and Drug Administration, the public is unable to participate in the decision-making process. This lack of a public discourse undermines the goals of the administrative state, which include democratic participation, transparency, and accountability.The United Kingdom, on the other hand, has had a markedly divergent experience with assisted reproductive technology innovation. Instead of ignoring the various ethical, social, and legal issues surrounding assisted reproductive technology innovation, the United Kingdom engaged in a five-strand public consultation on the topic of mitochondrial transfer, a form of assisted reproductive technology that uses genetic modification in order to prevent disease transmission. This article argues that after a multi-decade standstill in terms of the public discourse related to ethical issues associated with assisted reproductive technology and germline modification, it is time for the United States to institute a more democratic inquiry into the scientific, ethical, and social implications of new forms of assisted reproductive technology and ultimately, forthcoming medical innovations that involve genetic modification.