bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: a case report and literature review
Authors: Xu Tianmin , Wang Liang , Jia Yan , Jia Zanhui , Li Zhuo , Cui Shaohai , Cui Manhua 
Published: November 2019

AbstractBackgroundOvarian cancer during pregnancy is relatively rare and treatment strategies are inexperienced in surgery and chemotherapy. Multidisciplinary management of advanced epithelial ovarian cancer in pregnant patients with strong desire of fertility including sufficient mental and medical understanding, perioperative consideration, intraoperative decision, chemotherapy sensitivity and follow-up after treatment can gain successful outcomes for both maternal disease and fetus’s development.Case presentationA 34-year-old primigravidae was diagnosed with advanced epithelial ovarian tumor and then first cytoreductive surgery to resect macroscopical lesions and protect the uterus for fetus was performed following with four chemotherapy courses (docetaxel and carboplatin) before delivery and four other chemotherapy courses after delivery. Chemotherapy drugs were decided by sensitivity test and the patient’s anaphylaxis. Second surgery involved cesarean section with a healthy offspring and secondary cytoreductive surgery. Operative strategies were considered to gain a balance of disease and risk for fetus. Psychosocial support was provided during the course of diagnosis and treatment for a healthy coping situation. This patient relapsed 19 months after the last chemotherapy course and was treated by additional adjuvant therapy to a clinical remission. The 33-month baby boy has no evidence with disease until now. The follow-up of both mother and baby is still continuing.ConclusionsOvarian cancer during pregnancy has low incidence which must increase in future as women delay reproduction age. Ovarian cancer cytoreductive surgery and chemotherapy have limitation to handle conditions under a desire of fetus protection. Multidisciplinary treatment model is a therapeutic solution and a challenge for gynecological surgeons, medical oncologists, pathologists, obstetricians, neonatologists, pharmacists, anesthetist, and psychologists.
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
Authors: Mota Maria Beatriz S. , Carvalho Marcelo Alex , Monteiro Alvaro N. A. , Mesquita Rafael D. 
Published: November 2019

AbstractBackgroundThe maintenance of genomic integrity is the responsibility of a complex network, denominated the DNA damage response (DDR), which controls the lesion detection and DNA repair. The main repair pathways are base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination repair (HR) and non-homologous end joining repair (NHEJ). They correct double-strand breaks (DSB), single-strand breaks, mismatches and others, or when the damage is quite extensive and repair insufficient, apoptosis is activated.MethodsIn this study we used the BLAST reciprocal best-hit methodology to search for DDR orthologs proteins inAedes aegypti. We also provided a comparison betweenAe. aegypti,D. melanogasterand human DDR network.ResultsOur analysis revealed the presence of ATR and ATM signaling, including the H2AX ortholog, inAe. aegypti. Key DDR proteins (orthologs to RAD51, Ku and MRN complexes, XP-components, MutS and MutL) were also identified in this insect. Other proteins were not identified in bothAe. aegyptiandD. melanogaster, including BRCA1 and its partners from BRCA1-A complex, TP53BP1, PALB2, POLk, CSA, CSB and POLβ. In humans, their absence affects DSB signaling, HR and sub-pathways of NER and BER. Seven orthologs not known inD. melanogasterwere found inAe. aegypti(RNF168, RIF1, WRN, RAD54B, RMI1, DNAPKcs, ARTEMIS).ConclusionsThe presence of key DDR proteins inAe. aegyptisuggests that the main DDR pathways are functional in this insect, and the identification of proteins not known inD. melanogastercan help fill gaps in the DDR network. The mapping of the DDR network inAe. aegyptican support mosquito biology studies and inform genetic manipulation approaches applied to this vector.
Magnitude of intestinal parasitic infections and associated factors among food handlers working at Woldia University student’s cafeteria, Northeastern Ethiopia: an institution based cross-sectional study
Authors: Alemnew Birhan , Belay Yalemzewud , Demis Asmamaw 
Published: November 2019

Abstract

Objectives
The main aim of this study was to assess the Magnitude of intestinal parasitic infections and associated factors among food handlers working at Woldia University Student’s cafeteria, Northeastern Ethiopia. Institutional based cross-sectional study was conducted among 256 study participants in Woldia university student’s cafeteria, Northern Ethiopia. Systematic random sampling method was used to select the study participants. Data was collected using a standardized questionnaire by direct interviewing of study participants. Logistic regression was carried out to identify factors associated with intestinal parasitic infections.

Results
A total of 256 food handlers were enrolled making the overall magnitude of the intestinal parasite which was stool specimens positive for different diagnostic stages of parasites was found to be 43 (16.8%). Entamoeba histolytica/dispar was the most prevalent parasites 14 (5.5%), followed by Giardia lamblia 10 (3.9%). Lack of food safety training (AOR = 6.58; 95% CI 2.46–17.62), no regular medical checkup (AOR = 2.41; 95% CI 1.47–4.24), no handwashing practice after toilet by soap (AOR = 3.24; 95% CI 1.28–8.19), no handwashing practice before eating by soap (AOR = 4.03; 95% CI 1.64–9.91) and haven’t food preparation license (AOR = 6.13; 95% CI 2.18–17.22) were significantly associated with parasitic infection among food handlers.
Non-linear impact of exchange rate changes on U.S. industrial production
Authors: Habibi Arash 
Published: November 2019

Abstract
This paper contributes to the literature on the nexus between production and exchange rate in the United States (U.S.) by considering non-linear adjustments of exchange rate effects on industrial production in several sectors of the U.S. economy. We employ a Non-linear Autoregressive Distributed Lags (NARDL) model which is built upon the Solow model. We show that there exists a non-linear relationship between these two variables in some of the MMIGs. We document short-run non-linear effects of exchange rate on production of non-energy materials, durable manufacturing, consumer goods and business equipment. The short-run effects last into the long-run for all the sectors. While exchange rate changes have short-run linear effects on production of electricity in the U.S., there are no effects of exchange rate movements on the production of mining, and energy materials. Moreover, the paper finds misspecification error of the model for the case of durable manufacturing. The existence of non-linearities considering import content of exports, support our hypothesis and conclusions. Further, the factors that influence demand provide justifications for our results.
Factors contributing to medicines wastage in public health facilities of South West Shoa Zone, Oromia Regional State, Ethiopia: a qualitative study
Authors: Gebremariam Esayas Tadesse , Gebregeorgise Dawit Teshome , Fenta Teferi Gedif 
Published: November 2019

Abstract

Background
Medicines wastage is one of the challenges of health supply chain management in developing countries including Ethiopia. However, there is lack of objective evidence on the detailed underlying causes of medicines wastage. Therefore, the aim of this study is to explore factors contributing for medicines wastage in selected public health facilities of South West Shoa Zone, Oromia Regional State, Ethiopia.

Methods
A qualitative study was conducted in 10 public health facilities (1 General hospital and 9 health centers). An in-depth interview with flexible probing techniques was employed to collect the data from 20 key informants from May 2, 2016 to May 27, 2016. A semi structured interview guide was prepared to explore key informants’ idea about current situation of contributing factors and efforts made to reduce medicines wastage in public health facilities. A thematic analysis was then used to analyze the data.

Results
Almost all key informants felt that medicines wastage is increasing from time to time in their health facility due to supplier’s issuing of medicines without health facilities’ needs and request, failure to follow first expired first out principle in issuing medicines from stores to different dispensing units, lack of communication between supplier and health facilities, inadequate number of pharmacy personnel and weak monitoring system of supply chain in the health facilities. They also revealed budget constraint, stock out of medicines and congested store are of the major challenge that are compromising their service provision.

Conclusion
Medicine wastage is an ever-increasing problem in public health facilities of South West Shoa Zone. The problem is exacerbated due to absence of mechanisms to minimize the wastage. Health facilities, therefore, should place a mechanism to exchange medicines from overstocked facilities to under stocked ones; has to improve store management capacity by employing competent professionals, equipping the store with necessary technology and introducing a monitoring and evaluating health supply chain performance system in the health facilities.
Investigation of the solubility and dispersion degree of calf skin collagen in ionic liquids
Authors: Liu Sicong , Li Qian , Li Guoying 
Published: November 2019

AbstractThe dissolution of collagen in ionic liquids (ILs) was highly dependent on the polarity of ILs, which was influenced by their sorts and concentrations. Herein, the solubility and dispersion degree of collagen in two sorts of ILs, namely 1-ethyl-methylimidazolium tetrafluoroborate ([EMIM][BF4]) with low polarity and 1-ethyl-3-methylimidazolium acetate ([EMIM][Ac]) with high polarity in a concentration range from 10% to 70% at 10 °C were investigated. When 150 mg of collagen was added to 30 mg of ILs, the minimum soluble collagen concentration was 0.02 mg/mL in 70% [EMIM][BF4] with lowest polarity and the maximum was 3.57 mg/mL in 70% [EMIM][Ac] with highest polarity, which indicates that soluble collagen and insoluble collagen fibers were both present. For insoluble collagens, differential scanning calorimetry showed that the thermal-stability was weakened when increasing the ILs concentration and polarity, and the fiber arrangement was looser with a more uniform lyophilized structure, observed by atomic force microscopy and scanning electron microscopy. For soluble collagens, electrophoresis patterns and Fourier transform infrared spectroscopy showed that no polypeptide chain degradation occurred during dissolution, but the thermal denaturation temperature decreased by 0.26 °C~ 7.63 °C with the increase of ILs concentrations, measured by ultra-sensitive differential scanning calorimetry. Moreover, the aggregation of collagen molecules was reduced when ILs polarity was increased as determined by fluorescence measurements and dynamic light scattering, which resulted in an increased loose fiber arrangement observed by atomic force microscopy. If the structural integrity of collagen needs to be retained, then the ILs sorts and concentrations should be considered.Graphical abstract
Long-termin vivowear of different bearing types used for the Oxford Unicompartmental Knee Replacement
Authors: Mohammad Hasan R. , Campi Stefano , Kennedy James A. , Judge Andrew , Murray David W. , Mellon Stephen J. 
Published: November 2019

ObjectivesThe aim of this study was to determine the polyethylene wear rate of Phase 3 Oxford Unicompartmental Knee Replacement bearings and to investigate the effects of resin type and manufacturing process.MethodsA total of 63 patients with at least ten years’ follow-up with three bearing types (1900 resin machined, 1050 resin machined, and 1050 resin moulded) were recruited. Patients underwent full weight-bearing model-based radiostereometric analysis to determine the bearing thickness. The linear wear rate was estimated from the change in thickness divided by the duration of implantation.ResultsThe wear rate for 1900 resin machined (n = 19), 1050 machined (n = 21), and 1050 moulded bearings (n = 23) were 60 µm/year (sd 42), 76 µm/year (sd 32), and 57 µm/year (sd 30), respectively. There was no significant difference between 1900 machined and 1050 machined (p = 0.20), but 1050 moulded had significantly less wear than the 1050 machined (p = 0.05). Increasing femoral (p < 0.001) and tibial (p < 0.001) component size were associated with increasing wear.ConclusionWear rate is similar with 1050 and 1900 resin, but lower with moulded bearings than machined bearings. The currently used Phase 3 bearings wear rate is low (1050 moulded, 57 µm/year), but higher than the previously reported Phase 2 bearings (1900 moulded, 20 µm/year). This is unlikely to be due to the change in polyethylene but may relate to the minimally invasive approach used with the Phase 3. This approach, as well as improving function and thus increasing activity levels, may increase the risk of surgical errors, such as impingement or bearing overhang, which can increase wear. Surgeons should aim to use 4 mm thick bearings rather than 3 mm thick bearings in young patients, unless they are small and need conservative bone resections. Cite this article: Bone Joint Res 2019;8:535–543.
Para un examen crítico del comparatismo francés
Authors: Riaudel Michel , Zenarruza de Clément Silvia 
Published: November 2019

La ausencia de la literatura brasileña en los programas de literatura comparada de los concursos de reclutamiento de docentes en Letras modernas es el indicio del achicamiento de la disciplina a favor del trípode franco–anglo–germánico. Si una mayor apertura al mundo es necesaria, es sin embar-go delicado establecer umbrales de justas representaciones de las literaturas extranjeras. La cuestión remite, de hecho, a la constitución del valor literario, y pone de manifiesto también el carácter algo oblicuo de estudios efectuados en un marco estrictamente nacional. Es por eso que, paradójicamente, elhecho que los comparatistas inscriban en su campo la literatura brasileña y otros dominios olvidados podría enseñar a relativizar el pedestal nacional de los estudios literarios.
La construcción de la identidad femenina a través del espacio narrativo en Inés y la alegría de Almudena Grandes
Authors: Calero Jurado Rosa María 
Published: November 2019

Una de las propuestas de investigación trabajadas por la teoría literaria feminista es la posibilidad de que la literatura trasluzca un sujeto de mujer. En este sentido, se analizará la influencia del espacio narrativo en la novela Inés y la alegría de Almudena Grandes para la construcción de la identidad femenina de la protagonista. Para ello, se partirá del Feminismo de la Diferencia, siguiendo la teoría del orden simbólico de Hélène Cixous, Luce Irigaray y Julia Kristeva, y la teoría de las esferas separadas, que otorgaban el espacio privado del hogar a la mujer, dejando al hombre el mando de la sociedad. Así, se pondrá de manifiesto la importancia del espacio narrativo, siguiendo a José R. Valles Calatrava, para la construcción de la identidad femenina. A través del análisis literario se puede observar cómo las identidades de género se han formado tradicionalmente mediante un proceso de socialización esencialmente masculinizado y que responde al modelo patriarcal y, en consecuencia, cómo el espacio juega un papel fundamental para su deconstrucción y la posterior construcción de diferentes sujetos femeninos con identidad propia.
El cocoliche en cuestión
Authors: Di Tullio Ángela 
Published: November 2019

El cocoliche es una variedad surgida a partir del contacto entre el español y el italiano en determinadas condiciones históricas —en particular, las dos grandes oleadas de 1880–1914 y 1945–1955— y geográficas —la región del Litoral argentino. Si bien reducido por procesos de selección y simplificación, se nutrió de los diferentes dialectos italianos. El cambio de lengua de los inmigrantes tuvo envergadura social: el resultado del contacto entre lenguas y dialectos diferentes incidió en muchas de sus características más llamativas de la llamada «peculiaridad lingüística rioplatense».
La inmigración italiana en Santa Fe: español e italiano en contacto. Motivaciones, metodologías y primeros resultados de un proyecto internacional
Authors: Hajek John , Dorato Susana 
Published: November 2019

La inmigración italiana en Santa Fe y alrededores presenta un fenómeno de contacto e hibridación lingüística entre el español local y el italiano y los dialectos de los inmigrantes. Este campo de estudio hasta la fecha se presenta como una notable área de vacancia. El artículo constituye un avance sobre las motivaciones, metodologías y resultados de una primera etapa de trabajo en el marco de un proyecto internacional entre estudiosos de la Universidad del Litoral y la Universidad de Melbourne, Australia, tendiente a describir y analizar las características y las consecuencias del contacto.
La dramaturgia musical en el litoral. Una propuesta de estudio internacional
Authors: Cetrangolo Aníbal 
Published: November 2019

Se propone en este texto un examen comparativo referido a la actividad de teatro musical en el litoral argentino. El objeto lírico convoca al estudio interdisciplinario en cuanto el mismo reúne la actividad no solo de músicos sino también de literatos, artistas de lo visual y artesanos de profesiones muyespecíficas. Su estudio, en la Argentina de fines de siglo XIX y principios del siglo XX convoca necesariamente el examen de las migraciones. El registro de la historia de la ópera en el interior, desgraciadamente, es tema que, salvo muy pocas excepciones se circunscribe a la crónica circunstancial, motivada por lo general a la inauguración de algún teatro. Los archivos teatrales son exiguos: los programas de sala no fueron conservados de manera sistemática y no fueron elaborados elencos de espectáculos. Estos teatros más que producir espectáculos, fueron receptáculo de troupes itinerantes. Los pocos documentos conservados dan cuenta, en efecto, de la presencia de las compañías y de los miembros que las integraban. Es imprescindible el estudio de las publicaciones periódicas para reconstruir un pasado muy vital. Es solo la comparación de esos datos provenientes de las diferentes salas del área loque puede dar una idea de los itinerarios de esos grupos. Para hacer posible un estudio científico del tema y conocer el real espesor de esas producciones se impone, a su vez, el cotejo de los documentos provenientes de los teatros de la zona con los datos provenientes de las salas externas a ella, tanto de Buenos Aires como del exterior del país. Se describe la conformación de una base de datos ya activa hace decenas de años sobre estos temas y la incorporación a la misma de los datos provenientes de los teatros del litoral argentino.
Some observations on the dualistic nature of discourse processing
Authors: Heine Bernd 
Published: November 2019

AbstractA range of studies on language use suggests that there is a general contrast between two kinds of discourse processing. Based on a review of these studies, which rest on a number of different methodological approaches and perspectives, the present paper argues that there is in fact converging evidence in support of the hypothesis that linguistic discourse has a dualistic structure. Central to this structure is a distinction between what tends to be referred to, respectively, as the microstructure and the macrostructure of discourse. Furthermore, it is argued that the distinction shows significant neurolinguistic correlations, and that these correlations concern the lateralization of the cerebral brain.
White Identity and Ethno-Traditional Nationalism in Trump’s America
Authors: Kaufmann Eric 
Published: November 2019

AbstractAs the white share of America continues to decline, white identity is becoming more important for politics. I show that white identity is considerably stronger among whites who are attached to their ancestry, i.e. Irish, ‘American’ or Italian. Accordingly, we should see it as more reflective of cultural attachment than a desire for politico-economic advantage. In addition, a separate dynamic I term ethno-traditional American nationalism, is important. This is not white nationalism, but a form of American national identity in which ethnocultural elements form an important part but do not, like the American accent, form a condition of equal national membership. Ethno-traditional nationalism is about the ‘what is American’ question of symbolic attachment, rather than the ‘who is American’ question of which groups belong and are excluded, that has received the lion’s share of academic attention.
Upper bound of multiplicity in prime characteristic
Authors: Huong Duong Thi , Quy Pham Hung 
Published: November 2019

Abstract
Let

(
R
,
𝔪
)

{(R,\mathfrak{m})}

be a local ring of prime characteristic p and of dimension d with the embedding dimension v. Suppose the Frobenius test exponent for parameter ideals

Fte
⁡

(
R
)

{\operatorname{Fte}(R)}

of R is finite, and let

Q
=

p

Fte
⁡

(
R
)

{Q=p^{\operatorname{Fte}(R)}}

. It is shown that

e
⁢

(
R
)

≤

Q

v
-
d

⁢

(

v
d

)

.

e(R)\leq Q^{v-d}\binom{v}{d}.

We also improve the bound for F-nilpotent rings. Our result extends the main results of Huneke and Watanabe (2015) [6]
and of Katzman and Zhang (2019).[9].
Correlation between ore particle flow pattern and velocity field through multiple drawpoints under the influence of a flexible barrier
Authors: Qin Shikang , Chen Qingfa , Chen Qinglin , Zhao Fuyu 
Published: November 2019

Abstract
By means of similar tests, the stope room is scaled and the process of multiple-drawpoint ore drawing under the influence of a flexible barrier is simulated by the marking particle method. Based on the experimental phenomena and data, the shape of the barrier, the draw column, and the numerical relations for the discharge between each drawpoint are analysed. The velocity equation for ore particles flowing through multiple drawpoints is established and the relationship between ore particle flow properties and velocity fields is found. Finally, the following results are derived: 1) For each layer, the morphology of marked particles is similar to that of vertical velocity. The particles are quasi-linear in the upper part of the model and wavy in the lower part. The amplitude increases with decreasing height. 2) The distribution of thirteen concentric points of horizontal velocity in each layer illustrate that the ore particles drawn from each drawpoint are from the centreline between it and the adjacent drawpoint. 3) The barrier and the marked particles are at the lowest sag points at the top of the number two and number six drawpoints (close to the model’s side wall) because of the combination of vertical velocity and horizontal velocity.
A story at the periphery: Documenting, standardising and reviving Cypriot Arabic
Authors: Karyolemou Marilena 
Published: November 2019

AbstractThe aim of this article is to present the current sociolinguistic situation of the Cypriot Maronite community and report on recent efforts to revitalize its language, Cypriot Arabic or Sanna. After a brief historical account, the article focuses on the sociodemographic and sociolinguistic characteristics of the community, which has steadily declined ever since its establishment on the island of Cyprus in the seventh to eighth century AD. Finally, the article discusses the revitalization efforts undertaken since 2007 as well as recent political and social developments that (de)favour the process of revitalization.