bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol Use Disorder in a Culture That Normalizes the Consumption of Alcoholic Beverages: The Conflicts for Decision-Making
Authors: Messas Guilherme , Soares Maria Julia 
Published: December 2020

AbstractValue-Based Practice (VBP) allows individual and cultural values to be important elements in clinical decision-making. The following chapter exemplifies the application of this approach to a patient with an alcohol use disorder within the Brazilian culture, a culture that minimizes the impact of alcohol consumption on health. By applying principles such as shared decision-making and basing choices on evidence and values, the patient increased the adherence and, consequently, the effectiveness of the proposed treatment.
Journey into Genes: Cultural Values and the (Near) Future of Genetic Counselling in Mental Health
Authors: Crepaz-Keay David , Austin Jehannine , Weeks Lauren 
Published: December 2020

AbstractThrough a case narrative set in the near future, this chapter explores some of the cultural and values issues that are raised by recent advances in genetics and associated personalised medicine. On first inspection, these advances might be thought to resolve or at any rate ameliorate the values issues that arise in the context of shared clinical decision-making as the basis of personalised mental health practice in genetic counselling. On the contrary, however, as the case narrative illustrates, the values issues are considerably amplified. This is an instance of the ‘Science Driven’ principle of values-based practice: that the practical impact of advances in medical science and technology is to widen patients’ choices and with choices go values. The result is that advances in medical science and technology drive the need for enhanced values-based as well as evidence-based practice in responding to the challenges presented by personalised clinical care. The emerging resources for responding to these challenges in the context of psychiatric genetic counselling are described.
Policy-Making Indabas to Prevent “Not Listening”: An Added Recommendation from the Life Esidimeni Tragedy
Authors: Ujewe Samuel , Van Staden Werdie 
Published: December 2020

AbstractThis chapter reflects on the Life-Esidimeni tragedy in which more than 140 mental healthcare users died as a consequence of a policy decision. The main finding of an official investigation into these events was a “failure to listen or take advice”, but how this failure may be averted in the future did not feature among the recommendations of the Ombud’s report, this being mostly about further legal, regulatory and rights-based actions. To avert similar tragedies in the future, this chapter adds another recommendation. This is a practical decision-making process by which to listen properly in policy-making. Specifically, a policy-making indaba in an African version of values-based practice generates a space in which all stakeholders implied in the formulation and execution of a health policy may listen properly to each other about what matters to them in that context over and above the values captured in regulations and rights. The resulting policy may thus creatively account for the differences between values of the stakeholders without dismissing or changing anyone’s values.
Case Studies in the Culture of Professional Football Players and Mental Welfare and Wellbeing
Authors: Bennett Michael 
Published: December 2020

AbstractThis chapter draws on the author’s personal experience together with the findings from his qualitative research, to explore the cultural values driving problems of mental health and well-being among professional footballers. The study makes explicit the way in which players are expected to hide their experiences of being objectified—of being subject to gendered, racialised and other forms of dehumanisation—and denied a legitimate lived experience, an authentic heard voice. The chapter illustrates the importance in values-based practice of knowledge of values gained as in this instance by way of qualitative methods from the social sciences being used to fill out knowledge derived from individual personal experience.
Co-writing Values: What We Did and Why We Did It
Authors: Fulford Bill 
Published: December 2020

AbstractThis chapter reflects on the process and outcomes of our co-writing approach to the book. Section 2 describes the process of co-writing that we adopted. The challenges that emerged from this process resulted in the book itself becoming an exercise in values-based practice. Section 3 describes how we took forward a values-based approach in addressing these challenges by establishing a shared framework of values. Section 4 is about outcomes. Challenging as the co-writing approach we adopted turned out to be, we believe it has been at least provisionally justified by its outcomes, namely the quality and range of the contributions to the book. The diversity of perspectives represented by these contributions takes us a first step towards establishing an international ‘open society’ supporting innovation in mental health.
Die Migrantin retten!? Zum vertrackten Verhältnis von Geschlechtergewalt, Rassismus und Handlungsmacht
Authors: Dhawan Nikita , do Mar Castro Varela María 
Published: December 2020

ZusammenfassungDer vorliegende Beitrag beschäftigt sich mit den zwingenden feministischen Fragen nach Geschlechtergewalt, Verletzlichkeit, Handlungsmacht, deren Verknüpfungen und den Dilemmata, die jene spüren, die sexistische Gewalt, insbesondere innerhalb rassifizierter Communities, zu adressieren suchen. Dabei wird eine postkolonial-feministische Perspektive eingenommen, die eine Sicht auf Migration und Flucht erlaubt, bei der gleichzeitig feministische Mainstream-Annahmen mit Blick auf die andere Frau einer Kritik unterzogen werden. Angelehnt an Judith Butler wird dabei argumentiert, dass neue Formen kollektiver Handlungsmacht paradoxerweise gerade dort entstehen, wo eine spezifische Vulnerabilität verortet ist. Wenn auch eine sichtbare Verletzlichkeit häufig zu paternalistischen (Schutz-)Maßnahmen der hegemonialen Mehrheit führt, die gewaltvolle Geschlechterdynamiken stabilisieren, so können im Raum der Verwundbarkeit, wie Judith Butler feststellt, auch neue Formen von Handlungsmacht entstehen. Es ist in der Tat möglich, Opfer und zeitgleich Handlungsmächtige zu sein.
Silicate-replacive high sulfidation massive sulfide orebodies in a porphyry Cu-Au system: Bor, Serbia
Authors: Klimentyeva Dina , Driesner Thomas , von Quadt Albrecht , Tončić Trajča , Heinrich Christoph 
Published: December 2020

AbstractThe Cu-Au deposit of Bor (Serbia) represents a continuum of mineralization styles, from porphyry-style ore occurring in quartz-magnetite-chalcopyrite veins and chalcopyrite disseminations to high-sulfidation epithermal Cu-Au ores in pyrite-chalcopyrite and anhydrite-sulfide veins. Decisive for the great economic importance of Bor is the presence of exceptionally rich high-sulfidation massive sulfide orebodies, composed of pyrite + covellite + chalcocite/digenite and minor anhydrite and enargite. They form irregular bodies measuring 0.5–10 million tons of ore grading up to 7% Cu, hosted by andesites and surrounded by intense argillic alteration. This study focuses on a small but rich underground orebody mined out recently, where limited drillcore is preserved for quantitative geochemical study. This paper documents the vein relationships within the deep porphyry-style orebody of Borska Reka, the transitional porphyry-epithermal veins, and the overlying and laterally surrounding epithermal massive sulfides of the Bor deposit. Geological observations indicate that the formation of massive sulfide orebodies concludes the ore formation. Mass balance calculations, recast into geologically realistic bulk fluid-rock reactions, confirm textural evidence that near-isovolumetric replacement of andesite host rocks is the dominant formation mechanism of massive sulfide orebodies at Bor, whereby all lithophile elements including Si are dissolved and only Ti stays relatively immobile. While net volume changes for individual mineralization styles within the massive sulfide orebody vary from − 16% volume loss to + 127% volume gain, overall volume change for the whole massive sulfide orebody was probably slightly negative. Brecciation is important only as means of creating channelways for reactive fluid that turns the andesite protolith into massive sulfide, whereas net breccia infill occurred only locally.
Clinical diagnoses vs. autopsy findings in early deceased septic patients in the intensive care: a retrospective cohort study
Authors: Driessen Rob G. H. , Latten Bartholomeus G. H. , Bergmans Dennis C. J. J. , Hulsewe Riquette P. M. G. , Holtkamp Johanna W. M. , van der Horst Iwan C. C. , Kubat Bela , Schnabel Ronny M. 
Published: December 2020

AbstractEarly death in sepsis occurs frequently; however, specific causes are largely unknown. An autopsy can contribute to ascertain causes of death. The objective of the study was to determine discrepancies in clinical diagnosis and postmortem findings in septic intensive care unit (ICU) patients deceased within 48 h after ICU admission. All septic ICU patients who deceased within 48 h after ICU admission were identified and included. Four intensivists determined the clinical cause of death by medical record review. An autopsy was performed within 24 h of death. Clinical diagnosis and postmortem findings were compared and classified as autopsy-identified missed clinical diagnoses and autopsy-refuted diagnoses. Class I and II missed major diagnoses using the Goldman criteria were scored. Between 2012 and 2017, 1107 septic patients were admitted to ICU. Of these, 344 patients (31%) died, of which 97 patients (28%) deceased within 48 h. In 32 (33%) early deceased patients, an autopsy was agreed. There were 26 autopsy-identified missed clinical diagnoses found, mostly myocardial infarction (n = 4) and pneumonia (n = 4). In four patients (13%), a class I discrepancy was found. In fourteen patients (42%), a class II discrepancy was found. In conclusion, an autopsy is an important diagnostic tool that can identify definite causes of death. These diagnoses deviate from diagnoses established during admission in early deceased sepsis patients.
Integrin α11β1 is a receptor for collagen XIII
Authors: Koivunen Jarkko , Tu Hongmin , Kemppainen Antti , Anbazhagan Padmanabhan , Finnilä Mikko A. , Saarakkala Simo , Käpylä Jarmo , Lu Ning , Heikkinen Anne , Juffer André H. , Heino Jyrki , Gullberg Donald , Pihlajaniemi Taina 
Published: December 2020

AbstractCollagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors that mediate signals from the environment into the cells and vice versa. Integrin α11β1 is a collagen receptor known to recognize the GFOGER (O=hydroxyproline) sequence in collagens. Interestingly, collagen XIII and integrin α11β1 both have a role in the regulation of bone homeostasis. To study whether α11β1 is a receptor for collagen XIII, we utilized C2C12 cells transfected to express α11β1 as their only collagen receptor. The interaction between collagen XIII and integrin α11β1 was also confirmed by surface plasmon resonance and pull-down assays. We discovered that integrin α11β1 mediates cell adhesion to two collagenous motifs, namely GPKGER and GF(S)QGEK, that were shown to act as the recognition sites for the integrin α11-I domain. Furthermore, we studied the in vivo significance of the α11β1-collagen XIII interaction by crossbreeding α11 null mice (Itga11−/−) with mice overexpressingCol13a1(Col13a1oe). When we evaluated the bone morphology by microcomputed tomography,Col13a1oemice had a drastic bone overgrowth followed by severe osteoporosis, whereas the double mutant mouse line showed a much milder bone phenotype. To conclude, our data identifies integrin α11β1 as a new collagen XIII receptor and demonstrates that this ligand-receptor pair has a role in the maintenance of bone homeostasis.
Triangulating Submanifolds: An Elementary and Quantified Version of Whitney’s Method
Authors: Boissonnat Jean-Daniel , Kachanovich Siargey , Wintraecken Mathijs 
Published: December 2020

AbstractWe quantise Whitney’s construction to prove the existence of a triangulation for any$$C^2$$C2manifold, so that we get an algorithm with explicit bounds. We also give a new elementary proof, which is completely geometric.
Towards understanding vaccine hesitancy and vaccination refusal in Austria
Authors: Bauer Anja , Tiefengraber Daniel , Wiedermann Ursula 
Published: December 2020

SummaryIn Austria, data on vaccine hesitancy is scarce. Available studies suggest around 1-11% of parents refuse vaccination, while many more are hesitant and consider refraining from some but not all of the recommended vaccinations. However, the key drivers for vaccine hesitancy in Austria are largely unknown. To learn more about vaccination coverage, attitude towards and knowledge around immunization as well as views on mandatory vaccination, we conducted a survey in a rural Austrian lay population including adults and children. Two paper-based questionnaires, one for adults 16 years or older and one for children aged 6-15 years, were developed, then sent to all houses of a rural community in Austria as well as handed out at the local primary and middle school, respectively. Self-reported coverage rates of children and adults were found to be low. Within the surveyed population 3% of children had never been or do not get vaccinated. More than half (57%) of the survey participants had a positive attitude towards vaccines, 21% were without reserves, 16% were found skeptical and 5% had a generally negative attitude. Knowledge about immunization in general was poor. Younger adults and people with secondary education appear to be most skeptical and negative towards vaccination. Children’s attitudes were closely linked to those of their parents. The major concern around vaccination in adults was fear of side effects. In adults, 54.2% support mandatory vaccination for Health Care Workers and 20.7% are against it. 39% of adults and 37% of children wanted more information on vaccination, preferably provided by physicians. Knowledge about disease prevention by vaccination should be improved and children could also benefit from an early age-appropriate vaccine education to strengthen health literacy. Physicians are the most trusted source of health information. Medical doctors should be aware of their very important role in transmitting trusted health information. This should include an up-to-date education in communicable disease prevention and immunization during their whole medical career. Furthermore, the curricula of health-care workers may need to be improved and harmonized concerning prevention and vaccination.
Association between operation volume and postoperative mortality in the elective open repair of infrarenal abdominal aortic aneurysms: systematic review
Authors: Ronellenfitsch U. , Meisenbacher K. , Ante M. , Grilli M. , Böckler D. 
Published: December 2020

AbstractBackgroundAn inverse association between the case volume per hospital and surgeon and perioperative mortality has been shown for many surgical interventions. There are numerous studies on this issue for the open treatment of infrarenal aortic aneurysms.AimTo present the available data on the association between the case volume per hospital and surgeon and perioperative mortality in the elective open repair of infrarenal aortic aneurysms in a systematic review.Materials and methodsUsing the PubMed, Cochrane Library, Web of Science Core Collection, CINAHL, Current Contents Medicine (CCMed), and ClinicalTrials.gov databases, a systematic search was performed using defined keywords. From the search results, all original papers were included that compared the elective open repair of an infrarenal aortic aneurysm in a “high volume” center with a “low volume” center or by a “high volume” surgeon with a “low volume” surgeon, as defined in the respective study.ResultsAfter deduplication, the literature search yielded 1021 hits of which 60 publications met the inclusion criteria. Of these, 37/43 studies showed a lower mortality in “high volume” compared to “low volume” centers and 14/17 comparisons showed a lower mortality for “high volume” compared to “low volume” surgeons. The effect measures, usually odds ratios, ranged from 0.37 to 0.99 for volume per hospital and 0.31 to 0.92 for volume per surgeon. Regarding the threshold values for the definition of “high volume” and “low volume,” a clear heterogeneity was shown between the individual studies.DiscussionThe available data on the association between the case volume per hospital and surgeon and perioperative mortality in the elective open repair of infrarenal aortic aneurysms show that interventions performed in “high volume” centers or by “high volume” surgeons are associated with lower mortality. To ensure the best possible outcome in terms of low perioperative mortality in the open repair of infrarenal aortic aneurysms, the aim should be centralization with high case volume per hospital and surgeon.
Preconditioning Techniques for the Numerical Solution of Flow in Fractured Porous Media
Authors: Antonietti Paola F. , De Ponti Jacopo , Formaggia Luca , Scotti Anna 
Published: December 2020

AbstractThis work deals with the efficient iterative solution of the system of equations stemming from mimetic finite difference discretization of a hybrid-dimensional mixed Darcy problem modeling flow in fractured porous media. We investigate the spectral properties of a mixed discrete formulation based on mimetic finite differences for flow in the bulk matrix and finite volumes for the fractures, and present an approximation of the factors in a set of approximate block factorization preconditioners that accelerates convergence of iterative solvers applied to the resulting discrete system. Numerical tests on significant three-dimensional cases have assessed the properties of the proposed preconditioners.
Influencing factors analysis in pear disease recognition using deep learning
Authors: Yang Fang , Li Fuzhong , Zhang Kai , Zhang Wuping , Li Shancang 
Published: December 2020

AbstractInfluencing factors analysis plays an important role in plant disease identification. This paper explores the key influencing factors and severity recognition of pear diseases using deep learning based on our established pear disease database (PDD2018), which contains 4944 pieces of diseased leaves. Using the deep learning neural networks, including VGG16, Inception V3, ResNet50 and ResNet101, we developed a “DL network + resolution” scheme that can be used in influencing factors analysis and diseases recognition at six different levels. The experimental results demonstrated that the resolution is directly proportional to disease recognition accuracy and training time and the recognition accuracies for pear diseases are up to 99.44%,98.43%, and 97.67% for Septoria piricola (SP), Alternaria alternate (AA), and Gymnosporangium haracannum (GYM), respectively. The results also shown that a forward suggestion on disease sample collection can significantly reduce the false recognition accuracy.
A High-Order Conservative Semi-Lagrangian Solver for 3D Free Surface Flows with Sediment Transport on Voronoi Meshes
Authors: Bergami Matteo , Boscheri Walter , Dimarco Giacomo 
Published: December 2020

AbstractIn this paper, we present a conservative semi-Lagrangian scheme designed for the numerical solution of 3D hydrostatic free surface flows involving sediment transport on unstructured Voronoi meshes. A high-order reconstruction procedure is employed for obtaining a piecewise polynomial representation of the velocity field and sediment concentration within each control volume. This is subsequently exploited for the numerical integration of the Lagrangian trajectories needed for the discretization of the nonlinear convective and viscous terms. The presented method is fully conservative by construction, since the transported quantity or the vector field is integrated for each cell over the deformed volume obtained at the foot of the characteristics that arises from all the vertexes defining the computational element. The semi-Lagrangian approach allows the numerical scheme to be unconditionally stable for what concerns the advection part of the governing equations. Furthermore, a semi-implicit discretization permits to relax the time step restriction due to the acoustic impedance, hence yielding a stability condition which depends only on the explicit discretization of the viscous terms. A decoupled approach is then employed for the hydrostatic fluid solver and the transport of suspended sediment, which is assumed to be passive. The accuracy and the robustness of the resulting conservative semi-Lagrangian scheme are assessed through a suite of test cases and compared against the analytical solution whenever is known. The new numerical scheme can reach up to fourth order of accuracy on general orthogonal meshes composed by Voronoi polygons.
BRCA1/2mutations and survival of high-grade endometrioid endometrial cancer
Authors: Dai Yibo , Wang Jingyuan , Zhao Luyang , Wang Zhiqi 
Published: December 2020

AbstractBackgroundBRCA1/2mutations have been shown to be associated with the development of many solid tumors including endometrial cancer (EC). The objectives of this study are to analyze the association betweenBRCA1/2mutational status and clinicopathological characteristics as well as outcomes in EC patients.Methods510 eligible EC patients from the Cancer Genome Atlas database were included in the study. The association between clinicopathological characteristics and differentBRCA1/2mutational status was compared and analyzed. Analyses of the impact ofBRCAmutations on survival in EC patients was conducted using Kaplan-Meier survival analyses and Cox regressions. In order to control confounding bias between groups, propensity score matching method was used.ResultsAmong the eligible patients, 11 (2.2%) harboredBRCA1mutation, 43 (8.4%) harboredBRCA2mutation, and 36 (7.1%) harbored both. Body mass index, rates of hypertension history, proportion of non-endometrioid histology and rates of positive peritoneal cytology were lower in patients withBRCA1/2mutations compared with the group of wild-type counterpart (p = 0.020, 0.048, 0.001 and 0.012, respectively). Patients withBRCA1/2mutations showed longer overall (OS) and recurrence-free survival (RFS) (in Kaplan-Meier analyses, p < 0.001 and p = 0.004, respectively; in Cox regressions, p = 0.001 and 0.007, respectively). Further analyses showed that the impact ofBRCAmutations on survival was significant only in patients with high-grade endometrioid EC. Based on the cohorts generated after propensity score matching, in high-grade endometrioid EC patients, the influence ofBRCA1/2mutations remained significant on OS, but not on RFS (p = 0.003 and 0.057 in Kaplan-Meier analyses, p = 0.020 and 0.071 in Cox regressions).ConclusionBRCA1/2mutations are associated with better survival in patients with high grade endometrioid EC, indicating the value ofBRCAtesting in EC clinical management.
Judicial Big Data and Big-Data-Based Legal Research in China
Authors: ZUO Weimin , WANG Chanyuan 
Published: December 2020

AbstractThe newly established judicial-transparency platforms, like China Judgements Online, have provided access to a new resource—judicial big data—making it possible to conduct empirical, big-data-based legal research. However, as is often the case with new products, these platforms—China Judgements Online, in particular—pose a few problems for big-data-based legal research: insufficient academic depth; immature technical methods; and lack of innovation due to flawed data, strict technical thresholds, and lack of theoretical ambition and ability. In the future, big-data-based legal research should make use of current data resources, continue to promote statistical science and computer science in research, and apply small-data research methods, and in the meanwhile pay attention to the combination of data and theory.