bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of antenatal care on neonatal mortality among neonates in Ethiopia: a systematic review and meta-analysis
Authors: Tolossa Tadesse , Fekadu Ginenus , Mengist Belayneh , Mulisa Diriba , Fetensa Getahun , Bekele Daniel 
Published: November 2020

AbstractBackgroundAs compared to other regions of the world, Sub Saharan Africa (SSA) is the region with the highest neonatal mortality and is the region showing the least progress in the reduction of newborn death. Despite better progress made in reducing neonatal mortality, Ethiopia contributes the highest rate of neonatal death in Africa. In Ethiopia, findings from few studies were inconsistent and there is a need to systematically pool existing data to determine the impact of antenatal care on neonatal mortality among mother-neonate pairs in Ethiopia.MethodsPublished articles from various electronic databases such as Medline, Hinari, Pub Med, Cochrane library, the Web of Science, and Google Scholar were accessed. Also, unpublished studies from library catalogs were identified. All observational studies that were conducted on the association between antenatal care follow-up and neonatal mortality among neonates in Ethiopia were included. Data were extracted on the Microsoft Excel spreadsheet and analyzed using STATA 14.1 version. A random-effects model was used to estimate the pooled estimate with a 95% confidence interval (CI). Forest plots were used to visualize the presence of heterogeneity and estimate the pooled impact on antenatal care on neonatal mortality. The presence of publication bias was assessed by funnel plots and Egger’s statistical tests.ResultsInitially, a total of 345 studies were accessed. Finally, 28 full-text studies were reviewed and fourteen studies fulfilled inclusion criteria and included in the final meta-analysis. The overall pooled estimate indicates the odds of neonatal death among neonates from women with antenatal care were 65% lower than those neonates from women who had no antenatal care follow-up (OR: 0.35, 95% CI: 0.24, 0.51).ConclusionsIn this systematic review and meta-analysis, lack of ANC follow-up increase the probability of neonatal mortality as compared to having ANC follow-up. Thus, we will recommend for more coverages of appropriate antenatal care where risk groups can best be identified and managed.
Education and training programmes for infection prevention and control professionals: mapping the current opportunities and local needs in European countries
Authors: Tsioutis Constantinos , Birgand Gabriel , Bathoorn Erik , Deptula Aleksander , ten Horn Lenny , Castro-Sánchez Enrique , Săndulescu Oana , Widmer Andreas F. , Tsakris Athanasios , Pieve Giulio , Tacconelli Evelina , Mutters Nico T. 
Published: November 2020

Abstract

Background
Studies have repeatedly highlighted the need for homogenisation of training content and opportunities in infection prevention and control (IPC) across European countries.

Objectives
To map current training opportunities for IPC professionals, define local needs and highlight differences, across 11 European countries (Cyprus, France, England, Germany, Greece, Italy, Netherlands, Poland, Romania, Spain, Switzerland).

Sources
From July 2018 to February 2019, IPC experts directly involved in IPC training and education in their countries and/or internationally were invited to complete a prespecified set of questions in order to provide a detailed description of IPC training opportunities and needs in their country.

Conclusions
IPC training among nurses and doctors varies greatly across countries, with differences in content and type of training (e.g., standardised curriculum, educational programme, clinical experience) duration, as well as in assessment and recognition/accreditation. The observed heterogeneity in IPC training between European countries can be eliminated through establishment of interdisciplinary region-wide training programmes, with common learning objectives, shared know-how and supported by national and international professional bodies.
Natural resource degradation tendencies in Ethiopia: a review
Authors: Wassie Simachew Bantigegn 
Published: November 2020

AbstractBackgroundEthiopia is gifted with abundant natural resources of adequate landmass, fertile soil, favorable climate, water, wildlife, and others. Many of its resources are not properly identified, well managed, and fully exploited. The concern of this review is collating the current state of knowledge about the status of land, water, forest, rangeland and wildlife resources, and hence, assesses their degradation tendencies.ResultsIn Ethiopia, natural resources are under the influence of various interconnected factors like population pressure, agricultural expansion, migration, rapid urbanization, resettlement, climate change, and environmental pollution. Its huge population number had been putting a great burden on the sustainability of almost all types of natural resources. There is, therefore, serious degradation of land, water, forest, rangeland, and wildlife resources that appear to feed off each other. This results in severe soil loss, low vegetative cover, unsustainable farming practice, continuous use of dung and crop residues for fuel, overgrazing, and destruction and/or migration of wildlife, which again are intensifying the degradation of available resources in a vicious circle. The process ends with amplified environmental consequences such as water quality deterioration, biodiversity decline, and averts ecosystem services. It further recapitulates towards diverse socio-economic problems, political instability, marginalization, poverty, and recurrent natural hazards. The Ethiopian governments have taken several steps to address these problems like launching soil and water conservation campaign, tree planting programs, and others; success to date, however, has been limited.ConclusionsSpecial attention has to be given to properly manage the natural resources and ecosystems; so that, it can continue to provide the goods and services the population need.
N6-methyladenine modification in noncoding RNAs and its function in cancer
Authors: Yang Xinyu , Hu Xiang , Liu Jinting , Wang Ruiqing , Zhang Chen , Han Fengjiao , Chen Yuhong , Ma Daoxin 
Published: November 2020

Abstract
Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer.
Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis
Authors: Lasolle Hélène , Elsensohn Mad-Hélénie , Wierinckx Anne , Alix Eudeline , Bonnefille Clément , Vasiljevic Alexandre , Cortet Christine , Decoudier Bénédicte , Sturm Nathalie , Gaillard Stephan , Ferrière Amandine , Roy Pascal , Jouanneau Emmanuel , Bertolino Philippe , Bardel Claire , Sanlaville Damien , Raverot Gérald 
Published: November 2020

Abstract
The purpose of this study was to analyze the impact of copy number variations (CNV) on sporadic pituitary neuroendocrine tumors (PitNETs) prognosis, to identify specific prognosis markers according to the known clinico-pathological classification. CGH array analysis was performed on 195 fresh-frozen PitNETs (56 gonadotroph, 11 immunonegative, 56 somatotroph, 39 lactotroph and 33 corticotroph), with 5 years post-surgery follow-up (124 recurrences), classified according to the five-tiered grading classification (invasion, Ki-67, mitotic index and p53 positivity). Effect of alterations on recurrence was studied using logistic regression models. Transcriptomic analysis of 32 lactotroph tumors was performed. The quantity of CNV was dependent on tumor type: higher in lactotroph (median(min–max) = 38% (0–97) of probes) compared to corticotroph (11% (0–77)), somatotroph (5% (0–99)), gonadotroph (0% (0–10)) and immunonegative tumors (0% (0–17). It was not predictive of recurrence in the whole cohort. In lactotroph tumors, genome instability, especially quantity of gains, significantly predicted recurrence independently of invasion and proliferation (p-value = 0.02, OR = 1.2). However, no specific CNV was found as a prognostic marker. Transcriptomic analysis of the genes included in the CNV and associated with prognosis didn’t show significantly overrepresented pathway. In somatotroph and corticotroph tumors, USP8 and GNAS mutations were not associated with genome disruption or recurrence respectively. To conclude, CGH array analysis showed genome instability was dependent on PitNET type. Lactotroph tumors were highly altered and the quantity of altered genome was associated with poorer prognosis though the mechanism is unclear, whereas gonadotroph and immunonegative tumors showed the same ‘quiet’ profile, leaving the mechanism underlying tumorigenesis open to question.
Exploring the transition from natural to synthetic dyes in the production of 19th-century Central Asian ikat textiles
Authors: Tamburini Diego , Breitung Eric , Mori Chika , Kotajima Tomoko , Clarke Matthew L. , McCarthy Blythe 
Published: November 2020

Abstract
This study focuses on the dye analysis of 26 ikat textiles present in the collection of the Arthur M. Sackler Gallery and originally collected by Dr. Guido Goldman with the aim to gain additional information about their provenance and dating. The investigation exploits the full potential of a multi-analytical approach, starting with a non-invasive survey of all the colors using fiber optic reflectance spectroscopy (FORS), which revealed the presence of indigo and insect-based red dyes. These data were used to select areas from which samples were taken and analyzed by high performance liquid chromatography diode array detector (HPLC–DAD). These results enabled most of the natural sources of dyes to be fully identified, including American cochineal (Dactylopius coccus), madder (probably Rubia tinctorum), lac (probably Kerria lacca), larkspur (Delphinum semibarbatum), pagoda tree flower buds (Sophora japonica), grape vine leaves (Vitis vinifera), indigo and tannins. Complex mixtures of dyes were present in most samples, as a result of both the ikat making process itself and traditional dyeing practices. Synthetic dyes were identified in 9 of the textiles. Samples were re-analyzed using HPLC–DAD coupled to mass spectrometry (HPLC–DAD-MS). Malachite green (basic green 4, C.I. 42000), fuchsine (basic violet 14, C.I. 42510), rhodamine B (basic violet 10, C.I. 45170) and methyl violet (basic violet 1, C.I. 42535) were identified, and a few other tentatively identified synthetic dyes (probably orange I, II and IV, rhodamine 6G, patent blue V and alizarin yellow GG) were detected. As the first synthesis of early synthetic dyes is well documented, their presence was used to refine the dating of these textiles. The contextualization of the results also appeared to support the stylistic assumption that more intricate and colorful designs with a higher level of complexity are dated earlier than simpler, larger and more graphic ones. The overall information acquired reveals a dynamic scenario and an interesting window into the dyers’ experiments and adjustments to the economic and technological changes of the nineteenth century.
A data model for enhanced data comparability across multiple organizations
Authors: Obilikwu Patrick , Ogbuju Emeka 
Published: November 2020

Abstract
Organizations may be related in terms of similar operational procedures, management, and supervisory agencies coordinating their operations. Supervisory agencies may be governmental or non-governmental but, in all cases, they perform oversight functions over the activities of the organizations under their control. Multiple organizations that are related in terms of oversight functions by their supervisory agencies, may differ significantly in terms of their geographical locations, aims, and objectives. To harmonize these differences such that comparative analysis will be meaningful, data about the operations of multiple organizations under one control or management can be cultivated, using a uniform format. In this format, data is easily harvested and the ease with which it is used for cross-population analysis, referred to as data comparability is enhanced. The current practice, whereby organizations under one control maintain their data in independent databases, specific to an enterprise application, greatly reduces data comparability and makes cross-population analysis a herculean task. In this paper, the collocation data model is formulated as consisting of big data technologies beyond data mining techniques and used to reduce the heterogeneity inherent in databases maintained independently across multiple organizations. The collocation data model is thus presented as capable of enhancing data comparability across multiple organizations. The model was used to cultivate the assessment scores of students in some schools for some period and used to rank the schools. The model permits data comparability across several geographical scales among which are: national, regional and global scales, where harvested data form the basis for generating analytics for insights, hindsight, and foresight about organizational problems and strategies.
Short-term perinatal oxygen exposure may impair lung development in adult mice
Authors: Kumar Vasantha H. S. , Wang Huamei , Nielsen Lori 
Published: November 2020

AbstractBackgroundHyperoxia at resuscitation increases oxidative stress, and even brief exposure to high oxygen concentrations during stabilization may trigger organ injury with adverse long-term outcomes in premature infants. We studied the long-term effects of short-term perinatal oxygen exposure on cell cycle gene expression and lung growth in adult mice.MethodsWe randomized mice litters at birth to 21, 40, or 100%O2for 30 min and recovered in room air for 4 or 12 weeks. Cell cycle gene expression, protein analysis, and lung morphometry were assessed at 4 and 12 weeks.ResultsThe principal component analysis demonstrated a high degree of correlation for cell cycle gene expression among the three oxygen groups. Lung elastin was significantly lower in the 100%O2groups at 4 weeks. On lung morphometry, radial alveolar count, alveolar number, and septal count were similar. However, the mean linear intercept (MLI) and septal length significantly correlated among the oxygen groups. The MLI was markedly higher in the 100%O2groups at 4 and 12 weeks of age, and the septal length was significantly lower in the 100%O2groups at 12 weeks.ConclusionShort-term exposure to high oxygen concentrations lead to subtle changes in lung development that may affect alveolarization. The changes are related explicitly to secondary crest formation that may result in alteration in lung elastin. Resuscitation with high oxygen concentrations may have a significant impact on lung development and long-term outcomes such as BPD in premature infants.
Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery: SMILE and FS-LASIK
Authors: Li Meiyan , Yang Danjuan , Zhao Yu , Yang Weiming , Shang Jianmin , Zhou Xueyi , Yao Peijun , Yang Dong , Lin Xue , Zhou Xingtao 
Published: November 2020

AbstractBackgroundTo investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) surgery.MethodsA prospective, nonrandomized, cohort study: 80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE & ENT Hospital, Fudan University. Ablation ratio was defined as lenticule thickness (SMILE cases) or ablation depth (FS-LASIK cases) divided by central corneal thickness (CCT). Posterior corneal elevation changes were recorded as posterior central elevation (PCE), posterior corneal surface at thinnest point (PTE) and posterior corneal mean elevation (PME). Patients were followed up at 6-month and 5-year interval to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FS-LASIK surgery.ResultsPCE dropped at the 6-month follow-up for both SMILE (decreased by −1.11 ± 2.93 μm,P < 0.05) and FS-LASIK groups (decreased by −0.46 ± 3.72 μm,P < 0.05). PTE also dropped in SMILE (reduced by −2.04 ± 3.02 μm,P < 0.05) and FS-LASIK group (reduced by −1.28 ± 4.21 μm,P < 0.05) at the 6-month follow-up. Stable PCE (elevation change: SMILE −0.28 ± 4.03 μm; FS-LASIK 0.79 ± 4.13 μm,P > 0.05) and PTE (elevation change: SMILE −0.08 ± 4.28 μm; FS-LASIK 1.42 ± 3.85 μm,P > 0.05) for both groups were recorded at the 5-year follow-up compared to the 6-month visit. Ablation ratio was strongly correlated with 5-year postoperative PCE (β = 2.68 ± 1.05,P < 0.01) and PTE (β = 2.35 ± 1.17,P < 0.05). Cut-off value for 5-year postoperative raised PCE and PTE was 27.3 and 27.1%, respectively.ConclusionsAblation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups. PCE and PTE underwent slight backward displacement 6-month postoperatively and remain stable at the 5-year follow-up. Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface was 27.3 and 27.1% for SMILE and FS-LASIK groups, respectively.
Disaster preparedness for metro projects: a social-cognitive perspective of Pakistan
Authors: Abid Muhammad , Umer Muhammad , Maqsoom Ahsen , Abid Zaineb 
Published: November 2020

Abstract
During the last decade, 2.4 billion individuals, the majority of which were residing in low economic growth countries, became victim of global disasters. As economic growth is correlated with the resilience of a nation against a disaster, therefore developing and underdeveloped nations significantly face higher magnitude of losses. With Pakistan being a developing country, the present study takes into account the most recently accomplished mega project of METROBUS service that is currently operational in the twin metropolitan cities of Pakistan i.e. Islamabad and Rawalpindi to study the pre and post development perspectives of project in terms of the hazard perception, prospect disaster threats it poses towards the society in case of major seismic activity and the magnitude of disaster preparedness associated to the potential hazardous circumstances as result of seismic event occurrence. Statistical evaluations for the current study were conducted utilizing the SmartPLS 3.0, being based upon the information collected through 336 self-supervised surveyed responses. The results of the current study indicated, the respondents to be highly in favor of the commute service project, but at the same time, they highlighted the concerns regarding socio-economic adversities faced during the project development phases as well as after its completion. Further, the respondents expressed major reservations regarding the disaster management measures taken by the potential stakeholders of the project. Despite the fact that most of the respondents were well educated, the lack of awareness regarding preparedness against any possible project related disastrous situation, was observed. To mitigate the potential disaster losses associated to the project, respondents suggested that the national authorities should proactively provide awareness to the public and assure the availability of all necessary facilities, in case of any hazardous situation; seismic in particular. Considering the practical implications, the current study may be useful for other developing countries, which too faced similar concerns during development of comparable megaprojects and share similar environmental conditions.
Empirical study on the effects of social network–supported group concept mapping
Authors: Shih Yen-An , Chang Ben 
Published: November 2020

Abstract
Social networks provide traditional concept mapping of new opportunities for concept construction with grouping, social interaction, and collaborative functions. However, little effort has been made to explore the effects of social network–supported concept mapping compared with traditional individual concept construction. This paper explores the effects of social network–supported group concept mapping (SCM) activity and compares them with the effects of individual concept mapping (ICM) activity. A platform named CoCoing.info (http://cocoing.info) is utilized to examine the SCM and ICM activities under three studies, which drove the following research questions: (1) Do map structure (i.e., propositions, hierarchies, examples, cross-links, and scores) and mapping activity (i.e., map modification period and frequency) differ between ICM and SCM in students on specialized courses? (2) Do map structure and mapping activity differ between ICM and SCM in students on general education courses? (3) What are the effects of group size on SCM? In study I, four classes are selected to ensure a strong social network learning environment control. On the basis of study I, study II extends the controlled environment within an open social networking environment with a total of 1106 SCM maps and 569 ICM maps to produce an improved overview of concept mapping. The findings of studies I and II are consistent, demonstrating that the students constructed more comprehensive concept maps and had a higher modification period and frequency with SCM than with ICM, which indicates that in a social network learning environment, SCM is favorable to ICM. Study III considers each participant’s contributions to identify an optimal group number. The results of study III indicate that groups with two to seven members perform better than larger groups. Overall, the findings demonstrate the benefits of integrating concept mapping with social networking for student learning outcomes.