bluuebunny/crossref_metadata_2025_split huggingface dataset:
Processing seismic ambient noise data with the continuous wavelet transform to obtain reliable empirical Green's functions
Authors: Yang Yang , Liu Chunyu , Langston Charles A 
Published: May 2020

SUMMARYObtaining reliable empirical Green's functions (EGFs) from ambient noise by seismic interferometry requires homogeneously distributed noise sources. However, it is difficult to attain this condition since ambient noise data usually contain highly correlated signals from earthquakes or other transient sources from human activities. Removing these transient signals is one of the most essential steps in the whole data processing flow to obtain EGFs. We propose to use a denoising method based on the continuous wavelet transform to achieve this goal. The noise level is estimated in the wavelet domain for each scale by determining the 99 per cent confidence level of the empirical probability density function of the noise wavelet coefficients. The correlated signals are then removed by an efficient soft thresholding method. The same denoising algorithm is also applied to remove the noise in the final stacked cross-correlogram. A complete data processing workflow is provided with the overall data processing procedure divided into four stages: (1) single station data preparation, (2) removal of earthquakes and other transient signals in the seismic record, (3) spectrum whitening, cross-correlation and temporal stacking and (4) remove the noise in the stacked cross-correlogram to deliver the final EGF. The whole process is automated to make it accessible for large data sets. Synthetic data constructed with a recorded earthquake and recorded ambient noise is used to test the denoising method. We then apply the new processing workflow to data recorded by the USArray Transportable Array stations near the New Madrid Seismic Zone where many seismic events and transient signals are observed. We compare the EGFs calculated from our workflow with commonly used time domain normalization method and our results show improved signal-to-noise ratios. The new workflow can deliver reliable EGFs for further studies.
A qualitative investigation of school age children, their parents and school staff on their participation in the Digital Education to LImit Salt in the Home (DELISH) program
Authors: Bouterakos M , Booth A , Khokhar D , West M , Margerison C , Campbell K J , Nowson C A , Grimes C A 
Published: May 2020

Abstract
This study explored the views of participants who completed a 5-week, online, interactive, family-based, salt reduction education program (Digital Education to LImit Salt in the Home). A secondary aim was to explore the views of school staff on the delivery of food and nutrition education in schools. Children aged 7–10 years, their parents and principals/teachers from participating schools located in Victoria, Australia, completed a semi-structured evaluation interview. Audio-recordings of interviews were transcribed verbatim and analysed using NVivo. Twenty-eight interviews (13 children; 11 parents; 4 school staff) were included. Thematic analysis revealed that the program was well received by all groups. Children reported that the interactivity of the education sessions helped them to learn. Parents thought the program was interesting and important, and reported learning skills to reduce salt in the family diet. School staff supported the delivery of nutrition education in schools but indicated difficulties in sourcing well-packed nutrition resources aligned with the curriculum. It appears that there is support from parents and teachers in the delivery of innovative, engaging, nutrition education in schools, however such programs need to be of high quality, aligned with the school curriculum and readily available for incorporation within the school’s teaching program.
Lincolnshire and the third crusade: the list of crusaders from the deanery of Holland*
Authors: Bass Ian L 
Published: May 2020

Abstract
Two lists of crusaders, dating from 1196 to 1201, survive in Canterbury Cathedral Archives. This article examines the list of Lincolnshire crusaders and the conduct of the inquiry established to discover those backsliding on their vows. Particular attention is paid to the palaeography and dating of the list, and the context in which it was compiled, thus providing a new appraisal of its contents. Based on the testimonies, the article concludes that the list was compiled in the 1196 inquiry. To provide wider access to the document, a new diplomatic transcription is included along with English translation and historical notes.
Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn’s Disease Patients
Authors: Murate Kentaro , Maeda Keiko , Nakamura Masanao , Sugiyama Daisuke , Wada Hirotaka , Yamamura Takeshi , Sawada Tsunaki , Mizutani Yasuyuki , Ishikawa Takuya , Furukawa Kazuhiro , Ohno Eizaburo , Honda Takashi , Kawashima Hiroki , Miyahara Ryoji , Ishigami Masatoshi , Nishikawa Hiroyoshi , Fujishiro Mitsuhiro 
Published: May 2020

Abstract

Background and Aims
The therapeutic efficacy and safety of ustekinumab for Crohn’s disease (CD) have been reported from randomized controlled trials and real-world data. However, there are few studies describing the identification of patients most suitable for ustekinumab therapy. The aim of this study was to prospectively evaluate the patients receiving ustekinumab and identify predictors of the treatment efficacy.

Methods
Patients with moderate to severe active CD scheduled to receive ustekinumab were enrolled. The responders and nonresponders were compared at weeks 0, 8, 24, and 48 by evaluating patient demographics, simple endoscopic scores (SES-CD), ustekinumab and cytokine concentrations, and cellular fractions.

Results
The clinical response and clinical remission rates in the 22 enrolled patients were 59.1% and 31. 8% at week 8, 68.2% and 45.5% at week 24, and 54.4% and 40.9% at week 48, respectively. There were no significant differences in patients’ demographic and disease characteristics at baseline between responders and nonresponders. A combination of low SES-CD and high serum TNF-α concentration at baseline showed a good correlation with the clinical response. Serum TNF-α concentration was decreased because of the therapy. The ratio of CD4+TNF-α cells at baseline was significantly higher in responders than in nonresponders; however, the ratios of CD45+CD11b+TNF-α and CD45+CD11c+TNF-α cells were not different. The ratio of CD4+ TNF-α cells decreased with the treatment in the responders but not in the nonresponders.

Conclusions
The combination of 2 factors, namely higher serum TNF-α concentration and lower SES-CD at baseline, may assist clinicians in selecting the appropriate therapy for patients with moderate to severe CD.
Optimal power distribution method for energy storage system based on available capacity
Authors: Gege Liu 
Published: May 2020

Abstract
In order to eliminate the difference of the state of charge (SOC) among parallel battery energy storage systems, an optimization method of power distribution based on available capacity is proposed in this paper. The objective function and constraints are established to realize the optimal power allocation of battery energy storage and to improve the stability of the energy storage system. The simulation and experimental results are presented. The results have proved the corrective and effective of the method.
Correlations Among mRNA Expression Levels of ATP7A, Serum Ceruloplasmin Levels, and Neuronal Metabolism in Unmedicated Major Depressive Disorder
Authors: Liu Xuanjun , Zhong Shuming , Yan Lan , Zhao Hui , Wang Ying , Hu Yilei , Jia Yanbin 
Published: May 2020

AbstractBackgroundPrevious studies have found that elevated copper levels induce oxidation, which correlates with the occurrence of major depressive disorder (MDD). However, the mechanism of abnormal cerebral metabolism of MDD patients remains ambiguous. The main function of the enzyme ATPase copper-transporting alpha (ATP7A) is to transport copper across the membrane to retain copper homeostasis, which is closely associated with the onset of mental disorders and cognitive impairment. However, less is known regarding the association of ATP7A expression in MDD patients.MethodsA total of 31 MDD patients and 21 healthy controls were recruited in the present study. Proton magnetic resonance spectroscopy was used to assess the concentration levels of N-acetylaspartate, choline (Cho), and creatine (Cr) in brain regions of interest, including prefrontal white matter (PWM), anterior cingulate cortex (ACC), thalamus, lentiform nucleus, and cerebellum. The mRNA expression levels of ATP7A were measured using polymerase chain reaction (SYBR Green method). The correlations between mRNA expression levels of ATP7A and/or ceruloplasmin levels and neuronal biochemical metabolite ratio in the brain regions of interest were evaluated.ResultsThe decline in the mRNA expression levels of ATP7A and the increase in ceruloplasmin levels exhibited a significant correlation in MDD patients. In addition, negative correlations were noted between the decline in mRNA expression levels of ATP7A and the increased Cho/Cr ratios of the left PWM, right PWM, and right ACC in MDD patients. A positive correlation between elevated ceruloplasmin levels and increased Cho/Cr ratio of the left PWM was noted in MDD patients.ConclusionsThe findings suggested that the decline in the mRNA expression levels of ATP7A and the elevated ceruloplasmin levels induced oxidation that led to the disturbance of neuronal metabolism in the brain, which played important roles in the pathophysiology of MDD. The decline in the mRNA expression levels of ATP7A and the elevated ceruloplasmin levels affected neuronal membrane metabolic impairment in the left PWM, right PWM, and right ACC of MDD patients.
The Influence of Feed and Drinking Water on Terrestrial Animal Research and Study Replicability
Authors: Kurtz David M , Feeney William P 
Published: May 2020

AbstractFor more than 50 years, the research community has made strides to better determine the nutrient requirements for many common laboratory animal species. This work has resulted in high-quality animal feeds that can optimize growth, maintenance, and reproduction in most species. We have a much better understanding of the role that individual nutrients play in physiological responses. Today, diet is often considered as an independent variable in experimental design, and specialized diet formulations for experimental purposes are widely used. In contrast, drinking water provided to laboratory animals has rarely been a consideration in experimental design except in studies of specific water-borne microbial or chemical contaminants. As we advance in the precision of scientific measurements, we are constantly discovering previously unrecognized sources of experimental variability. This is the nature of science. However, science is suffering from a lack of experimental reproducibility or replicability that undermines public trust. The issue of reproducibility/replicability is especially sensitive when laboratory animals are involved since we have the ethical responsibility to assure that laboratory animals are used wisely. One way to reduce problems with reproducibility/replicability is to have a strong understanding of potential sources of inherent variability in the system under study and to provide “…a clear, specific, and complete description of how the reported results were reached [1].” A primary intent of this review is to provide the reader with a high-level overview of some basic elements of laboratory animal nutrition, methods used in the manufacturing of feeds, sources of drinking water, and general methods of water purification. The goal is to provide background on contemporary issues regarding how diet and drinking water might serve as a source of extrinsic variability that can impact animal health, study design, and experimental outcomes and provide suggestions on how to mitigate these effects.
HIV-DNA undetectability during chronic HIV infection: frequency and predictive factors
Authors: Nozza Silvia , Galli Laura , Gianotti Nicola , Parisi Mariarita , Poli Andrea , Cinque Paola , Spagnuolo Vincenzo , Bruzzesi Elena , Mastrangelo Andrea , Castagna Antonella 
Published: May 2020

Abstract

Background
HIV-DNA is a marker of HIV reservoirs. Objectives of the study were to determine prevalence of HIV-DNA &lt; 100 copies/106 PBMCs in blood and to identify factors associated with this in a cohort of HIV-1-infected subjects treated with ART and with undetectable viral load (VL).

Methods
This was a cross-sectional study on chronic HIV-1-infected people living with HIV (PLWH) followed up at the Department of Infectious Diseases of San Raffaele Scientific Institute on current ART without change for 12 months, with available pre-ART HIV-RNA and with undetectable VL for ≥12 months. HIV-DNA was amplified and quantified by real-time PCR (ABI Prism 7900); limit of detectability was 100 copies/106 PBMCs. Logistic regression was used to identify predictive factors for HIV-DNA &lt; 100 copies/106 PBMCs.

Results
Four hundred and sixty-eight PLWH were considered in the analyses, 119 (25%) with HIV-DNA &lt; 100 copies/106 PBMCs. At multivariate analysis, we found that PLWH with lower zenith HIV-RNA, higher nadir CD4 and a shorter time between HIV diagnosis and ART start were more likely to have HIV-DNA &lt; 100 copies/106 PBMCs, after adjustment for age, gender, calendar year of ART start, type of current ART regimen, percentage time spent with undetectable VL since ART start, current CD4 and CD4/CD8 ratio.

Conclusions
In our chronic PLWH on virological suppression for 4 years, the prevalence of HIV-DNA &lt; 100  copies/106 PBMCs was found to be 25%. Lower zenith HIV-RNA, shorter time between HIV diagnosis and starting ART and higher CD4 nadir were independently associated with low HIV-DNA.
Influence of Sorghum Cultivar, Nitrogen Fertilization, and Insecticides on Infestations of the Sugarcane Aphid (Hemiptera: Aphididae) in the Southern United States
Authors: Wilson B E , Reay-Jones F P F , Lama L , Mulcahy M , Reagan T E , Davis J A , Yang Y , Wilson L T 
Published: May 2020

Abstract
The sugarcane aphid, Melanaphis sacchari Zehntner, is an economically damaging pest of sorghum, Sorghum bicolor (L.), across the southern United States. Field experiments investigated impacts of sorghum cultivar, nitrogen fertilization, and insecticides on M. sacchari infestations and sorghum yields in Louisiana and South Carolina in 2017 and 2018. In South Carolina, M. sacchari densities in unprotected plots peaked on 30–31 July of both years before declining by early- to mid-August. In Louisiana, infestations peaked on 26 and 12 July for 2017 and 2018, respectively, and declined by mid-August. Nitrogen fertilization influenced M. sacchari densities in Louisiana in 2018 with the highest-level infestations recorded from plots that received high N rates. Densities of M. sacchari on susceptible sorghum cultivar, DKS 38-88, were 1.5- to 2.3-fold greater than on DKS 37-07 in both years in Louisiana and in 2018 in South Carolina. Nitrogen fertilization was associated with improved sorghum yields in Louisiana experiments. Sorghum yields across experiments were 2- to 4-fold greater in plots protected with multiple insecticide applications than in unprotected plots. Yield from plots with insecticides sprayed once at currently used action thresholds differed from unprotected plots only in the 2018 Louisiana experiment. Results from these experiments indicate insecticidal protection of susceptible sorghum cultivars remains critical throughout much of the southern United States. Further research is needed to develop integrated management programs that incorporate fertilization manipulation, cultivar resistance, and insecticidal control.
Research ethics in a pandemic: considerations for the use of research infrastructure and resources for public health activities
Authors: Doerr Megan , Wagner Jennifer K 
Published: May 2020

Abstract
The number and size of existing research studies with massive databases and biosample repositories that could be leveraged for public health response against SARS-CoV-2 (or other infectious disease pathogens) are unparalleled in history. What risks are posed by coopting research infrastructure—not just data and samples but also participant recruitment and contact networks, communications, and coordination functions—for public health activities? The case of the Seattle Flu Study highlights the general challenges associated with utilizing research infrastructure for public health response, including the legal and ethical considerations for research data use, the return of the results of public health activities relying upon research resources to unwitting research participants, and the possible impacts of public health reporting mandates on future research participation. While research, including public health research, is essential during a pandemic, careful consideration should be given to distinguishing and balancing the ethical mandates of public health activities against the existing ethical responsibilities of biomedical researchers.
Mental Health Trajectories of Fathers Following Very Preterm Birth: Associations With Parenting
Authors: McMahon Grace E , Anderson Peter J , Giallo Rebecca , Pace Carmen C , Cheong Jeanie L , Doyle Lex W , Spittle Alicia J , Spencer-Smith Megan M , Treyvaud Karli 
Published: May 2020

AbstractObjectiveMothers of infants born very preterm (VPT) are at high risk of mental health difficulties. However, less is known about the course of fathers’ depressive and anxiety symptoms over time, and the implications this may have for early parenting behaviors.MethodsIn total, 100 fathers of 125 infants born VPT (&lt;30 weeks’ gestation) completed questionnaires assessing depressive and anxiety symptoms shortly after their infant’s birth, and when their infant reached term-equivalent age, 3 months, 6 months, and 12 months’ corrected age. At 12 months’ corrected age, fathers’ parenting behaviors were assessed using the Emotional Availability Scales. Longitudinal latent class analysis was used to identify trajectories of fathers’ depressive and anxiety symptoms, and linear regression equations examined relationships between these trajectories and fathers’ parenting behaviors.ResultsFor both depressive and anxiety symptoms, two distinct trajectories were identified. For depression, most fathers were assigned to the persistently low symptom trajectory (82%), while the remainder were assigned to the persistently high symptom trajectory (18%). For anxiety, 49% of fathers were assigned to the persistently low symptom trajectory, while 51% were assigned to the trajectory characterized by moderate symptoms over the first postnatal year. There were no significant differences in parenting behaviors between fathers assigned to the different depressive and anxiety symptom trajectories.ConclusionsFathers of infants born VPT are at risk of chronic depressive and anxiety symptoms over the first postnatal year, highlighting the need for screening and ongoing support.
Pancreatic neuroendocrine tumor featuring growth into the main pancreatic duct and tumor thrombus within the splenic vein: a case report
Authors: Miyata Takashi , Takamura Hiroyuki , Kin Ryosuke , Nishiki Hisashi , Hashimoto Akifumi , Fujii Yoritaka , Miura Seiko , Fujita Jun , Kaida Daisuke , Tomita Yasuto , Nakamura Naohiko , Fujita Hideto , Kinami Shinichi , Ueda Nobuhiko , Kosaka Takeo 
Published: May 2020

AbstractA 48-year-old woman was admitted to our hospital because of upper abdominal pain. Computer tomography showed an enhancing mass in the pancreatic body, dilation of the main pancreatic duct (MPD) and a filling defect within the splenic vein. On the basis of the preoperative diagnosis of pancreatic body cancer, distal pancreatectomy was scheduled. The pancreas was divided along the left edge of the gastroduodenal artery; however, frozen pathological examination of the pancreatic stump was tumor positive, and therefore a total pancreatectomy was performed. The lesion was a white expansive nodular mass that had spread into the MPD and protruded into the splenic vein. A pathological diagnosis of non-functioning neuroendocrine tumor (NET) was made. In general, imaging findings of disruption of the MPD and tumor vein thrombus are characteristics of pancreatic ductal adenocarcinoma, but are uncommon in NET. However, NET should be included in the differential diagnosis for such patients.
Semi-analytical orbital dynamics around the primary of a binary asteroid system
Authors: Wang Yue , Fu Tao 
Published: May 2020

ABSTRACT
The orbital dynamics in the vicinity of a binary asteroid system has been studied extensively, motivated by the special dynamical environment and possible exploration missions. Equilibrium points, periodic orbits, and invariant manifolds have been investigated in many studies based on the model of the Restricted Full Three Body Problem (RF3BP). In this paper, a new semi-analytical orbital dynamical model around the primary of a binary system is developed as a perturbed two-body problem. The solution includes the effect of the primary's oblateness and the secondary's third-body gravity. The semi-analytical dynamical model, also denoted as the averaged model, is obtained by using the averaging process and Lagrange planetary equations in terms of the Milankovitch orbital elements. This semi-analytical model enables much faster orbital propagations than the non-averaged counterpart, and is particularly useful in orbital stability analysis and the design of long-term passively stable orbits and orbits with specific performance, e.g. frozen orbits. The applicability of the semi-analytical model is then discussed. Two parameters describing relative magnitudes of both perturbations w.r.t. the primary's point mass gravity and the third parameter related to the orbital period ratio w.r.t. the secondary are defined to provide indicators for the validity of the averaged model. The validity boundaries in terms of the three parameters are given based on numerical simulations, by comparing with the full orbital model. The application to a real binary system, 2003 YT1, has shown that the averaged solution has a high precision in the long-term orbital propagation.