bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Non-Traditional Lipid Parameters with Hemorrhagic Transformation and Clinical Outcome After Thrombolysis in Ischemic Stroke Patients
Authors: Luo Yun , Chen Jie , Yan Xiu-Li , Jin Hang , Sun Xin , Guo Zhen-Ni , Yang Yi 
Published: January 2021

Objective::
Recently, a few studies have shown that non-traditional lipid parameters are
associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke.
However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous
thrombolysis remains unclear. Thus, we aimed to assess the associations of non-traditional
lipid parameters with HT and clinical outcome after thrombolysis in ischemic stroke patients.

Methods::
This study consecutively included 763 ischemic stroke patients treated with intravenous
thrombolysis. Non-traditional lipid parameters included non-high-density lipoprotein cholesterol
(non-HDL-C), total cholesterol to HDL-C ratio (TC/HDL-C), triglyceride to HDL-C ratio (TG/
HDL-C), and low-density lipoprotein cholesterol to HDL-C ratio (LDL-C/HDL-C). Receiver operating
characteristic (ROC) curves and multivariate logistic regression analyses were used to investigate
the associations between the four non-traditional lipid parameters and HT and poor outcome
after thrombolysis.

Results::
Of 763 patients, 78 (10.2%) had HT and 281 (36.8%) had poor outcome. The ROC curves
showed that the optimum cut-off points of the non-HDL-C, TC/HDL-C, TG/HDL-C, and
LDL/HDL-C for predicting HT and poor outcome were 2.99 and 2.01, 4.05 and 3.66, 0.82 and
1.02, as well as 2.67 and 2.71, respectively. Multivariate logistic regression analyses showed that
the TC/HDL-C <4.05 (adjusted odds ratio [OR]=1.727, 95% confidence interval [CI]:
1.008–2.960), TG/HDL-C <0.82 (adjusted OR=2.064, 95% CI: 1.241–3.432), and LDL/HDL-C
<2.67 (adjusted OR=1.935, 95% CI: 1.070–3.501) were positively associated with the risk of HT,
while the non-HDL-C <2.99 (adjusted OR=0.990, 95% CI: 0.583–1.680) was not related to the risk
of HT. In addition, the non-HDL-C <2.01, TC/HDL-C <3.66, TG/HDL-C <1.02, and LDL/HDL-C
<2.71 were associated with an increased risk of poor outcome, with adjusted ORs of 2.340 (95%
CI: 1.150–4.764), 1.423 (95% CI: 1.025–1.977), 1.539 (95% CI: 1.102–2.151), and 1.608 (95% CI:
1.133–2.283).

Conclusion::
Low TC/HDL-C, TG/HDL-C, and LDL/HDL-C, but not non-HDL-C, were associated
with an increased risk of HT after thrombolysis. In addition, low non-HDL-C, TC/HDL-C,
TG/HDL-C, and LDL/HDL-C were associated with an increased risk of poor outcome in ischemic
stroke patients with intravenous thrombolysis.
Recent Advancements in Fuzzy C-means Based Techniques for Brain MRI Segmentation
Authors: Latif Ghazanfar , Alghazo Jaafar , Sibai Fadi N. , Iskandar D.N.F. Awang , Khan Adil H. 
Published: January 2021

Background:
Variations of image segmentation techniques, particularly those used for Brain MRI
segmentation, vary in complexity from basic standard Fuzzy C-means (FCM) to more complex and enhanced FCM
techniques.

Objective:
In this paper, a comprehensive review is presented on all thirteen variations of FCM segmentation
techniques. In the review process, the concentration is on the use of FCM segmentation
techniques for brain tumors. Brain tumor segmentation is a vital step in the process of automatically
diagnosing brain tumors. Unlike segmentation of other types of images, brain tumor segmentation
is a very challenging task due to the variations in brain anatomy. The low contrast of brain images
further complicates this process. Early diagnosis of brain tumors is indeed beneficial to patients,
doctors, and medical providers.

Results:
FCM segmentation works on images obtained from magnetic resonance imaging (MRI)
scanners, requiring minor modifications to hospital operations to early diagnose tumors as most, if
not all, hospitals rely on MRI machines for brain imaging.

Conclusion:
In this paper, we critically review and summarize FCM based techniques for brain
MRI segmentation.
Antimutagenic, Antiproliferative and Antioxidant Properties of Sea Grape Leaf Extract Fractions (Coccoloba uvifera L.)
Authors: Ramos-Hernández Jorge A. , Calderón-Santoyo Montserrat , Burgos-Hernández Armando , García-Romo Joel S. , Navarro-Ocaña Arturo , Burboa-Zazueta María G. , Sandoval-Petris Edgar , Ragazzo-Sánchez Juan A. 
Published: January 2021

Background:
Cancer is a disease characterized by the invasion and uncontrolled growth of cells.
One of the best ways to minimize the harmful effects of mutagens is through the use of natural antimutagens. In
this regard, the search for new antimutagens that act in the chemoprevention could represent a promising field
in this area.

Objective:
In this study biological potential of 11 fractions from Coccoloba uvifera L. leaf hexane extract was
evaluated by several in vitro tests.

Methods:
Leaves were lyophilized and hexane extraction was performed. The extract was fractionated by column
chromatography with hexane, ethyl acetate, and methanol. The antimutagenic (Ames test), antiproliferative
(MTT test), and antioxidant capacity (DPPH, ABTS, and ferrous ion chelation) of the fractions were evaluated.

Results::
Fractions 4, 6, 8, and 9 have antimutagenic activity (against sodium azide in strain TA100), fraction 11
showed antiproliferative capacity (IC50 of 24 ± 9 μg/mL in cells of HCT 116). The fractions with the highest activity
were analyzed by HPLC-MS and lupeol, acacetin, and β-sitosterol were identified.

Conclusion:
This study demonstrates, for the first time, the bioactivity of C. uvifera leaf as a new source of
High Biological Value Compounds (HBVC), which can be of interest to the food and pharmaceutical industries.
Cytotoxicity and Anti-Inflammatory Effects of Polyherbal Formulations, Joint Pain Spl and Rumalaya Forte on Lipopolysaccharide Induced Inflammation in IC-21 Macrophages
Authors: Koodalingam Arunagirinathan , Rajalakshmi Arumugam , Parthiban Ezhumalai 
Published: January 2021

Aim:
To test the effectiveness of marketed polyherbal formulations on
lipopolysaccharide-induced inflammatory conditions in macrophages.

Background:
Usage of herbal compounds among patients suffering from arthritis and cancer is increasing
every year. Many anti-inflammatory herbal products available in the market should be
screened thoroughly for their possible mechanism of action.

Objective:
Joint Pain Spl (JPS) is a polyherbal dietary food supplement composed of 13 herbal
plants, and Rumalaya Forte (RF) is a polyherbal formulation comprising of 6 herbal plants. These
were tested for their cytotoxicity, as well as antioxidant and anti-inflammatory activities in LPS
treated IC-21 peritoneal macrophages.

Methods:
Commercially available JPS and RF powder was used to prepare the extract. The aqueous
and methanol extracts were quantified for the presence of phenolic and flavonoid compounds
and confirmed with HPLC. In vitro DPPH free scavenging activity was performed. Cytotoxicity
was tested by MTT assay. Anti-inflammatory activity was tested using lipopolysaccharide-stimulated
IC-21 peritoneal macrophage cells.

Results:
The phytochemical screening showed the presence of phenolic and flavonoid compounds
in JPS and RF. The aqueous and methanol extracts of JPS and RF possesses significant DPPH free
radical scavenging activity. MTT assay revealed that 90.64% (aqueous extract) and 92.21%
(methanol extract) of exposed macrophages are viable even after 24h exposure of maximal tested
concentrations of herbal formulations. Pre-treatment of JPS and RF on LPS induced IC-21
macrophages showed a reduction in nitric oxide production (maximal 79.95%) and a high level of
superoxide anion scavenging activity (maximal 82.5%) over control.

Conclusion:
The two tested polyherbal formulations, such as JPS and RF possess anti-inflammatory
activity by modulating free radical generation in IC-21 macrophages. Thus the presence of the
phenolic and flavonoid compounds may contribute to the antioxidant activity.
SARS-CoV-2: An Insight into Detection Tools
Authors: Khanmohammadi Shaghayegh , Tabary Mohammadreza , Araghi Farnaz , Tavangar Seyed Mohammad 
Published: January 2021

:
The novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2), was announced as a pandemic in March 2020. Different diagnostic laboratory tests have been used to detect
the infection. Each diagnostic tool, such as Chest Computed tomography (CT) imaging, genome sequencing, nucleic acid
amplification methods, whole genome sequencing, microarray, and serology testing have several advantages and
disadvantages. Nucleic acid amplification methods are better diagnostic tools for the detection of SARS-CoV-2 in early
stages of the infection, while serological tests are more appropriate for the recognition of previously infected patients. In this
review, we will briefly consider each diagnostic method, and discuss its pros and cons.
Modifications of Medical Care of Chronic Liver Diseases During
COVID-19 Pandemic: Necessity or Novelty?
Authors: Soliman Hanan Hamed , Emara Mohamed H. , Elkadeem Mahmoud , Abd-Elsalam Sherief 
Published: January 2021

:
In the late 2019, coronavirus-2 (SARS-COV 2) infection emerged in Wuhan, China and spread to all countries
making the first pandemic in 21st century. It seems that this infection will continue period which is long enough to obligate
modifications in both life style and health care systems. Because chronic liver diseases (CLD) are prevalent all over the
world, it is expected to manage patients with CLD and COVID-19. The aim of this review was to shade the light on the
impact of COVID-19 pandemic on the management of patients with CLD and how to give medical care to CLD patients
during COVID-19 pandemic.
The Effect of a Name-Based Mask Rationing Plan in Taiwan on Public Anxiety Regarding a Mask Shortage During the COVID-19 Pandemic: Observational Study
Authors: Tai Yu-Lin , Chi Hsin , Chiu Nan-Chang , Tseng Cheng-Yin , Huang Ya-Ning , Lin Chien-Yu 
Published: January 2021

Background
The COVID-19 pandemic is a severe global health crisis. Wearing a mask is a straightforward action that can be taken, but shortage of stock and equity of allocation were important issues in Taiwan. Furthermore, increased anxiety leading to the stockpiling of masks has been common during the pandemic.

Objective
We aim to summarize the name-based mask rationing plan implemented in Taiwan and explore the public’s perceived anxiety about mask shortages.

Methods
The government of Taiwan took action to control the supply and allocation of face masks. We summarize the timeline and important components of the mask rationing plan. A survey that aimed to investigate the overall response to the mask rationing plan was answered by 44 participants.

Results
The mask rationing plan was implemented in late January 2020. Daily production capacity was increased from 2 million masks to 16 million masks in April 2020. People could buy 9 masks in 14 days by verification via their National Health Insurance card. Digital face mask availability maps were created. Moreover, the mask plan safeguarded the purchase of masks and resulted in decreased anxiety about a mask shortage (4.05 [SD 1.15] points; 72.7% [n=32] of participants answered “agree” or “strongly agree”). The majority of people felt that the mask plan was satisfactory (4.2 [SD 0.92] points; 79.5% [n=35] of participants answered “agree” or “strongly agree”).

Conclusions
We found that the unique name-based mask rationing plan allowed for control of the production and supply of masks, and contributed to the appropriate allocation of masks. The mask rationing plan not only provided the public with physical protection, but also resulted in reduced anxiety about mask shortages during the pandemic.
Tip-Cylinder Electrode Plasma to Enhance the Coating of Conductive Yarn Process
Authors: Putra Valentinus Galih Vidia , Zulfikar Lutfi , Sumihartanti Atin , Mohamad Juliany Ningsih , Yusuf Yusril 
Published: January 2021

This study aims to develop conductive textile materials using a polyester textile yarn by applying a knife coating method and pre-treatment of a tip-cylinder plasma electrode. In this research, carbon ink was coated on polyester staple yarn which was given a pre-treatment with a plasma generator and coated with the knife coating method. The electrical conductivity of conductive yarns produced from this study was divided into two types, as yarns without plasma treatment and with plasma treatment with a ratio of water and carbon ink concentrations of 1:1 and 2:1. The results of the electrical conductivity with plasma treatment and the concentration of carbon ink and water of 1:1 and 1:2 were 69005 (Ωm)-1 and 50144.25 (Ωm)-1, respectively, while the results of the electrical conductivity for threads with concentrations of carbon ink and water of 1:1 and 1:2 without plasma treatment were 18197.64 (Ωm)­‑1 and 8873.54 (Ωm)-1, respectively. The results showed that the concentration of carbon ink and water and plasma treatment affected the conductive value of the yarn. The results also showed that the presence of plasma pre-treatment improved the coating process of conductive ink on the yarn.Keywords: carbon ink; conductive yarn; plasma; textile A B S T R A KPenelitian ini bertujuan untuk mengembangkan bahan tekstil konduktif menggunakan benang tekstil poliester dengan mengaplikasikan metode knife coating dan pre-treatment plasma elektroda tip-cylinder. Pada penelitian ini dilakukan pelapisan dengan tinta karbon pada benang poliester stapel yang diberi perlakuan awal dengan plasma generator dan dilapisi dengan metode pelapisan knife coating. Konduktivitas listrik benang konduktif yang dihasilkan dari penelitian ini dibagi menjadi dua jenis, yaitu benang tanpa perlakuan plasma dan dengan perlakuan plasma dengan perbandingan konsentrasi air dan tinta karbon sebesar 1:1 dan 2:1. Hasil konduktivitas listrik dengan perlakuan plasma dan konsentrasi tinta karbon dan air sebesar 1:1 dan 1:2 masing-masing adalah 69005 (Ωm)‑1 dan 50144,25 (Ωm)-1, sedangkan hasil konduktivitas listrik untuk benang dengan konsentrasi tinta karbon dan air sebesar 1:1 dan 1:2 tanpa perlakuan plasma masing-masing adalah 18197,64 (Ωm)-1 dan 8873,54 (Ωm)-1. Hasil penelitian menunjukkan bahwa konsentrasi tinta karbon dan air serta perlakuan plasma berpengaruh terhadap nilai konduktivitas benang serta adanya pre-treatment plasma dapat meningkatkan proses coating tinta konduktif pada benang.Kata kunci: benang konduktif; plasma; tekstil; tinta karbon
Optimization of Self-Micro Emulsifying Drug Delivery System) for Soursop Leaf (Annona muricata Linn.) Chloroform Extract
Authors: Artanti Anif Nur , Prihapsara Fea , Ermawati Dian Eka , Shofa Aprilia Saefanan 
Published: January 2021

Soursop leaf chloroform extract has anticancer activity. The active ingredient of soursop leaf was acetogenin polypoid derivatives that have a lipophilic characteristic, and less effective to achieve action targets of drugs in biological systems. The Self-Micro Emulsifying Drug Delivery System (SMEDDS) was an effective drug delivery technique that increases the solubility of lipophilic drugs. This study aims to determine the proportion of optimum SMEDDS formula using Simplex Lattice Design (SLD) method. The Formula of SMEDDS was prepared using a combination of Tween 80-Croduret, Propylene Glycol, and Candlenut oil. Optimization formula with SLD method using Design-Expert software based on physical stability parameters there are the percent of transmittance and emulsification time. The optimum formula of SMEDDS was compared with SLD prediction formula using a statistical analysis t-test, then test of loading dose extract, stability test accelerated by centrifugation, particle size, and zeta potential. The proportion of optimum composition of Tween 80-Croduret, Propylene Glycol, and Candlenut oil of SMEDDS was 60.87%; 24.13%; 15.00% respectively. Results of transmittance 41.14±3.78% and emulsification time 119.0±2.08 seconds. The predicted SLD value for the transmittance percent was 55.0% and the emulsification time was 119.59 seconds. The result of the statistical analysis of one sample t-test showed no significant difference between observation results and SLD prediction. The SMEDDS system has F value of 0.99 and capable to load 25.0 mg chloroform extract of soursop leaf each system with an average particle size of 440 nm and zeta potential of +21.5 mV.
Esposito's temporality of finance: Endogeneity and revisability in derivative transactions
Authors: Husbands Conor 
Published: January 2021

AbstractRecent years have seen greater interest in the theoretical foundations of abstract finance and their intersection with questions of philosophy and sociology. In particular, exchanges between authors such as Donald MacKenzie, Timothy Johnson, Elie Ayache, and others have debated the deterministic or contingent dynamics of markets, as well as their interdependency with the theories that purport to describe them. Working in this tradition, Elena Esposito raises a novel question in her 2011 book, The Future of Futures: could the exchange of derivative securities within financial markets entail not so much the provision of liquidity, but the transaction of time? In this article, I reconstruct Esposito's analysis, arguing that the proper response to this question should be affirmative. Particular emphasis is laid on what I take to be the two fundamental and controversial premises which support this argument: first, the endogeneity of time-relations involved in financial markets; and second, the revisability of these time- relations. The advantage of recasting Esposito's position in this way is the defence it enables against various criticisms articulated in theory and philosophy circles, such as those of Ray Brassier. Finally, I discuss the significance of Esposito's theory, not only for this class of financial transactions, but also for certain issues in the philosophy of time.
Editorial
Authors: Jacovkis Pablo , Masello Diego 
Published: January 2021

<p><span lang="ES-AR">Buena parte de los investigadores e investigadoras de las ciencias sociales de nuestra región han dejado de utilizar la perspectiva estructural como un nivel preponderante para observar el desenvolvimiento de diferentes fenómenos, como algunos tópicos del mercado de trabajo, de los procesos y situaciones educativas, en relación a la evolución y determinación de la pobreza y la desigualdad, entre otros temas.</span></p><p><span lang="ES-AR">Los <span lang="ES-AR">trabajos que se presentan en <span lang="ES-AR">este número <span lang="ES-AR">apuntan a fenómenos claramente estructurales de nuestras sociedades: la estructura social y productiva, la inserción ocupacional, la educación, la formación y las posibilidades profesionales, los derechos humanos en relación con la vulnerabilidad del sistema democrático y, también, respecto a las perspectivas del análisis de redes sociales como una herramienta útil para caracterizar problemas estructurales.</span></span></span></span></p><p><span lang="ES-AR"><span lang="ES-AR"><span lang="ES-AR"><span lang="ES-AR">De este abanico de cuestiones nos interesa remarcar la importancia de dos dimensiones que están desarrolladas, de modos diferentes, en todos los artículos que se presentan. Por una parte, los aspectos estructurales vinculados con los problemas del mercado de trabajo y, por otro lado, la importancia de la metodología y las técnicas reticulares para ser utilizadas en los análisis de la estructura social y productiva.</span></span></span></span></p>
Cohesión de las estructuras resultantes en redes sociales: estudio de caso sobre la desaparición de personas en la Provincia de Tucumán
Authors: Salgado Ariel , Fumagalli Mariella , González Simonetto Analía , Ibañez Alejandra , Bernardi Patricia , Somigliana Carlos , Salado Puerto Mercedes , Caridi Inés 
Published: January 2021

<span lang="ES">En este trabajo se propone un método para caracterizar la calidad de las estructuras que surgen en redes de origen social, en términos de la homogeneidad de los agentes que integran esas estructuras o grupos. Las técnicas propuestas fueron pensadas para redes con pocas conexiones (<em>sparse networks</em>) en las que pueden determinarse grupos conectados entre sí y aislados del resto (los <em>clusters </em>de la red), aunque son inmediatamente extendibles a redes más densas, donde los grupos se determinan mediante métodos de detección de comunidades. Los grupos se evalúan de acuerdo con su similaridad u homogeneidad interna, con base en un conjunto pequeño de variables categóricas conocidas para todos los agentes de la red, del tipo </span><span lang="ES">TRUE/FALSE </span><span lang="ES">(pertenece o no a la categoría), que no fueron usadas en la definición de la red y que no necesariamente son disjuntas. Comparando cada grupo con lo esperado si las conexiones hubieran surgido por azar, podemos evaluar el grado en que la presencia de una categoría dentro de este, difiere de la aleatoriedad. Sin embargo, grupos con presencia fuerte de dos categorías que no se vinculan entre sí en la población completa no son consideramos como aceptables. La aplicación específica de esta metodología busca caracterizar las relaciones relevantes en un sistema de individuos mediante redes y conocer las estructuras emergentes para ordenar prioridades en la investigación de personas desaparecidas, ya que brinda conexiones, vínculos, recorridos y nodos, que pueden facilitar la comprensión del contexto y modo en el que operó la última dictadura militar argentina, en la provincia de Tucumán.</span>
¿Sueña la izquierda con ovejas eléctricas?
Authors: Díaz Guevara Héctor Hernán 
Published: January 2021

Reseña: Monedero, Juan Carlos (2018) <em>La izquierda que asaltó el algoritmo: Fraternidad y digna rabia en tiempos del Big Data</em>. Madrid: Catarata.
UTILIZAÇÃO DA SÉRIE ANIMADA “THE LAST AIRBENDER” E “LEGEND OF KORRA” COMO ALICERCE DE UMA PRÁTICA DOCENTE INCLUSIVA
Authors: Rodrigues Ramos Anderson , dos Santos Bonfim Gonçalves Pedro Antonio , Tamiasso-Martinhon Priscila , Sanches Rocha Angela 
Published: January 2021

A ampliação dos debates sobre inclusão tem trazido uma maior inserção e participação de gruposhistoricamente marginalizados em diversas mídias e ambientes sociais. Além disso, esses debates frequentementediscutem como esses grupos são simbolizados e representados. Este artigo analisa o engajamento de participantesem utilizar recursos como séries animadas em sua prática pedagógica trazendo questões que permeiam arepresentação desses grupos. O ponto de partida originou-se em uma palestra virtual em que a série animada de
televisão Avatar: The Last Airbender foi usada como tema gerador. Em seguida, procedeu-se a uma pesquisa quali-quantitativa exploratória com a participação de docentes e graduados, - que compartilharam suas percepções sobre a representatividade, quanto à sua importância e implicações - como base para uma reflexão sobre sua práticadocente. Utilizando textos selecionados para discutir o assunto, constatou-se que todos reconheceram a relevânciado tema e se posicionaram favoravelmente ao uso desse tipo de mídia em sua prática docente. Porém, declaramque suas ações seriam limitadas por um currículo rígido ou pelo excesso de tempo que seria necessário para aexecução de tal proposta.