bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformative or Not? How Privacy Violation Experiences Influence Online Privacy Concerns and Online Information Disclosure
Authors: Masur Philipp K , Trepte Sabine 
Published: December 2020

Abstract
Previous research has shown that people seldom experience privacy violations while using the Internet, such as unwanted and unknown sharing of personal information, credit card fraud, or identity theft. With this study, we ask whether individuals’ online privacy concerns increase and online information disclosure decreases if they experience such a worst-case scenario. Using representative data from a five-wave panel study (n = 745), we found that people who generally experience more privacy violations also have stronger privacy concerns (between-person differences). However, people who experienced more privacy violations than usual in the last 6 months were only slightly more concerned afterward and did not change their disclosure behavior afterward (within-person effects). The need for privacy moderated these processes. We untangle under which circumstances such experiences may be transformative, and discuss practical and conceptual consequences of how experiences translate into concerns, but not necessarily behaviors.
Short- and long-term effects of the patient education strategy—learning and coping—in cardiac rehabilitation: a randomized controlled trial (LC-REHAB)
Authors: Lynggaard V , Zwisler A D , Taylor R S , May O , Mortensen J , Nielsen C V 
Published: December 2020

Abstract
The objectives were to assess the short- and long-term effect of the patient education strategy ‘Learning and Coping’ (LC) in cardiac rehabilitation (CR) on health-related quality of life, patient education impact, cardiac risk factors and lifestyle. In total, 825 patients hospitalized with ischaemic heart disease or heart failure were randomized to either LC-CR or standard CR at three Danish hospitals. Teaching approach in LC-CR was situational, inductive and reflective, with experienced patients as co-educators and supplemental interviews. Teaching approach in standard CR was structured and deductive. Outcomes were assessed immediately after CR, and after 3 months (short term), and after 3 years (long term). Between-arm differences in favour of LC-CR were SF-12 ‘role emotional’ (3.7, 95% CI: 0.6–6.8) and MDI depression score (0.9, 0.1–1.8) immediately after CR, exercise capacity (4 W, 1–9) at 3 months and SF-12 ‘role physical’ (4.6, 0.1–9.0) (long term). Between-arm differences in favour of controls were waist circumference (−1.7 cm, −2.3 to −1.0) immediately after CR and HeiQ domain ‘Constructive attitudes and approaches’ (0.11, 0.04–0.18), triglycerides (−0.12 mmol/l, −0.21 to −0.02), systolic blood pressure (−3.12 mmHg, −5.66 to −0.58) at 3 months. Adding LC strategies to CR provides inconsistent short-term results but improves ‘role physical’ long term.
Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study
Authors: Brandkvist Maria , Bjørngaard Johan Håkon , Ødegård Rønnaug Astri , Åsvold Bjørn Olav , Smith George Davey , Brumpton Ben , Hveem Kristian , Richardson Tom G , Vie Gunnhild Åberge 
Published: December 2020

AbstractFrom a life-course perspective, genetic and environmental factors driving childhood obesity may have a lasting influence on health later in life. However, how obesity trajectories vary throughout the life-course remains unknown. Recently, Richardson et al. created powerful early life and adult gene scores for body mass index (BMI) in a comprehensive attempt to separate childhood and adult obesity. The childhood score was derived using questionnaire-based data administered to adults aged 40–69 regarding their relative body size at age 10, making it prone to recall and misclassification bias. We therefore attempted to validate the childhood and adult scores using measured BMI data in adolescence and adulthood among 66 963 individuals from the HUNT Study in Norway from 1963 to 2019. The predictive performance of the childhood score was better in adolescence and early adulthood, whereas the predictive performance of the adult score was better in adulthood. In the age group 12–15.9 years, the variance explained by the childhood polygenic risk score (PRS) was 6.7% versus 2.4% for the adult PRS. In the age group 24–29.9 years, the variance explained by the adult PRS was 3.9% versus 3.6% for the childhood PRS. Our findings support that genetic factors driving BMI differ at young age and in adulthood. Within the framework of multivariable Mendelian randomization, the validated childhood gene score can now be used to determine the consequence of childhood obesity on later disease.
A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish
Authors: Koh Angela , Tao Shijie , Jing Goh Yun , Chaganty Vindhya , See Kelvin , Purushothaman Kathiresan , Orbán László , Mathuru Ajay S , Wohland Thorsten , Winkler Christoph 
Published: December 2020

AbstractNeurexins are presynaptic transmembrane proteins that control synapse activity and are risk factors for autism spectrum disorder. Zebrafish, a popular model for behavioral studies, has six neurexin genes, but their functions in embryogenesis and behavior remain largely unknown. We have previously reported that nrxn2a is aberrantly spliced and specifically dysregulated in motor neurons (MNs) in models of spinal muscular atrophy. In this study, we generated nrxn2aa−/− mutants by CRISPR/Cas9 to understand nrxn2aa function at the zebrafish neuromuscular junction (NMJ) and to determine the effects of its deficiency on adult behavior. Homozygous mutant embryos derived from heterozygous parents did not show obvious defects in axon outgrowth or synaptogenesis of MNs. In contrast, maternal-zygotic (MZ) nrxn2aa−/− mutants displayed extensively branched axons and defective MNs, suggesting a cell-autonomous role for maternally provided nrxn2aa in MN development. Analysis of the NMJs revealed enlarged choice points in MNs of mutant larvae and reduced co-localization of pre- and post-synaptic terminals, indicating impaired synapse formation. Severe early NMJ defects partially recovered in late embryos when mutant transcripts became strongly upregulated. Ultimately, however, the induced defects resulted in muscular atrophy symptoms in adult MZ mutants. Zygotic homozygous mutants developed normally but displayed increased anxiety at adult stages. Together, our data demonstrate an essential role for maternal nrxn2aa in NMJ synapse establishment, while zygotic nrxn2aa expression appears dispensable for synapse maintenance. The viable nrxn2aa−/− mutant furthermore serves as a novel model to study how an increase in anxiety-like behaviors impacts other deficits.
Repair of traumatic avulsion of the right bronchus in children using extracorporeal membrane oxygenation support
Authors: Ricciardi Gabriella , Putman Léon M , Hazekamp Mark G 
Published: December 2020

Abstract
Traumatic avulsion of the right main bronchus in children is usually caused by blunt trauma or traffic accidents. Primary repair by suturing is the preferred treatment. Lesions are life threatening and urgent or emergency surgical repair is indicated. We report our experience with 2 cases of traumatic avulsion of right bronchus in children successfully suture repaired with the use of extracorporeal membrane oxygenation.
Low HbA1c levels and all-cause or cardiovascular mortality among people without diabetes: the US National Health and Nutrition Examination Survey 1999–2015
Authors: Inoue Kosuke , Nianogo Roch , Telesca Donatello , Goto Atsushi , Khachadourian Vahe , Tsugawa Yusuke , Sugiyama Takehiro , Mayeda Elizabeth Rose , Ritz Beate 
Published: December 2020

Abstract

Objective
It is unclear whether relatively low glycated haemoglobin (HbA1c) levels are beneficial or harmful for the long-term health outcomes among people without diabetes. We aimed to investigate the association between low HbA1c levels and mortality among the US general population.

Methods
This study includes a nationally representative sample of 39 453 US adults from the National Health and Nutrition Examination Surveys 1999–2014, linked to mortality data through 2015. We employed the parametric g-formula with pooled logistic regression models and the ensemble machine learning algorithms to estimate the time-varying risk of all-cause and cardiovascular mortality by HbA1c categories (low, 4.0 to &lt;5.0%; mid-level, 5.0 to &lt;5.7%; prediabetes, 5.7 to &lt;6.5%; and diabetes, ≥6.5% or taking antidiabetic medication), adjusting for 72 potential confounders including demographic characteristics, lifestyle, biomarkers, comorbidities and medications.

Results
Over a median follow-up of 7.5 years, 5118 (13%) all-cause deaths, and 1116 (3%) cardiovascular deaths were observed. Logistic regression models and machine learning algorithms showed nearly identical predictive performance of death and risk estimates. Compared with mid-level HbA1c, low HbA1c was associated with a 30% (95% CI, 16 to 48) and a 12% (95% CI, 3 to 22) increased risk of all-cause mortality at 5 years and 10 years of follow-up, respectively. We found no evidence that low HbA1c levels were associated with cardiovascular mortality risk. The diabetes group, but not the prediabetes group, also showed an increased risk of all-cause mortality.

Conclusions
Using the US national database and adjusting for an extensive set of potential confounders with flexible modelling, we found that adults with low HbA1c were at increased risk of all-cause mortality. Further evaluation and careful monitoring of low HbA1c levels need to be considered.
Multiple Degrees of Freedom in the Fish Skull and Their Relation to Hydraulic Transport of Prey in Channel Catfish
Authors: Olsen A M , Hernandez L P , Brainerd E L 
Published: December 2020

SynopsisFish perform many complex manipulation behaviors without hands or flexible muscular tongues, instead relying on more than 20 movable skeletal elements in their highly kinetic skulls. How fish use their skulls to accomplish these behaviors, however, remains unclear. Most previous mechanical models have represented the fish skull using one or more planar four-bar linkages, which have just a single degree of freedom (DoF). In contrast, truncated-cone hydrodynamic models have assumed up to five DoFs. In this study, we introduce and validate a 3D mechanical linkage model of a fish skull that incorporates the pectoral girdle and mandibular and hyoid arches. We validate this model using an in vivo motion dataset of suction feeding in channel catfish and then use this model to quantify the DoFs in the fish skull, to categorize the motion patterns of the cranial linkage during feeding, and to evaluate the association between these patterns and food motion. We find that the channel catfish skull functions as a 17-link, five-loop parallel mechanism. Despite having 19 potential DoFs, we find that seven DoFs are sufficient to describe most of the motion of the cranial linkage, consistent with the fish skull functioning as a multi-DoF, manipulation system. Channel catfish use this linkage to generate three different motion patterns (rostrocaudal wave, caudorostral wave, and compressive wave), each with its own associated food velocity profile. These results suggest that biomechanical manipulation systems must have a minimum number of DoFs to effectively control objects, whether in water or air.
Characterization of a vancomycin-resistant Enterococcus faecium isolate and a vancomycin-susceptible E. faecium isolate from the same blood culture
Authors: Xanthopoulou Kyriaki , Wille Julia , Zweigner Janine , Lucaßen Kai , Wille Thorsten , Seifert Harald , Higgins Paul G 
Published: December 2020

Abstract

Objectives
To characterize two Enterococcus faecium isolates with different resistance phenotypes obtained from the same blood culture.

Methods
The isolates were identified by MALDI-TOF MS and antimicrobial susceptibility testing (AST) was performed using a VITEK® 2 AST P592 card and Etest. WGS was performed on the MiSeq and MinION sequencer platforms. Core-genome MLST (cgMLST) and seven-loci MLST were performed. Plasmid analysis was performed using S1-PFGE followed by Southern-blot hybridization.

Results
Both E. faecium isolates were ST203. AST revealed that one was a vancomycin-resistant E. faecium (VREfm) isolate and the other was a vancomycin-susceptible E. faecium (VSEfm) isolate. The VREfm isolate harboured the vanA gene cluster as part of a Tn1546-type transposon encoded on a 49 kb multireplicon (rep1, rep2 and rep7a) plasmid (pAML0157.1). On the same plasmid, ant(6)-Ia, cat-like and erm(B) were encoded. The VSEfm isolate harboured a rep2 plasmid (pAML0158.1), 12 kb in size, which was present in full length as part of pAML0157.1 from the VREfm isolate. The vanA-encoding pAML0157.1 was a chimera of the rep2 pAML0158.1 and a second DNA segment harbouring vanA, ant(6)-Ia, erm(B) and cat-like, as well as the replicons rep1 and rep7a. By cgMLST analysis, the VREfm and VSEfm isolates were identical.

Conclusions
Our results demonstrate that the VREfm and VSEfm blood culture isolates represented ST203 and were identical. The investigated heterogeneous resistance phenotypes resulted from the acquisition or loss of plasmid segments in the enterococcal isolates. These data illustrate that mobile genetic elements may contribute to the spread of vancomycin resistance among enterococci and to the genotypic and phenotypic variation within clonal isolates.
A call to strengthen data in response to COVID-19 and beyond
Authors: Azzopardi-Muscat Natasha , Kluge Hans Henri P , Asma Samira , Novillo-Ortiz David 
Published: December 2020

Abstract
The COVID-19 (coronavirus disease 2019) pandemic has underscored the critical need for all countries to strengthen their health data and information systems and ensure the routes the data travel, from submission to use, are unobstructed. Timely, credible, reliable, and actionable data are key to ensuring that political decisions are data driven and facilitate understanding, monitoring, and forecasting. To ensure that critical decisions related to the wider health and socioeconomic effects of this pandemic are data driven, each country needs to develop or enhance a national data governance plan that includes a clear coordination mechanism, well-defined and documented data processes (manual or electronic), the exchange of data, and a data culture to empower users. In addition, countries should now more than ever invest and enhance their data and health information systems to ensure that all decisions are data driven and that they are prepared for what is next.
STAN: spatio-temporal attention network for pandemic prediction using real-world evidence
Authors: Gao Junyi , Sharma Rakshith , Qian Cheng , Glass Lucas M , Spaeder Jeffrey , Romberg Justin , Sun Jimeng , Xiao Cao 
Published: December 2020

Abstract

Objective
We aim to develop a hybrid model for earlier and more accurate predictions for the number of infected cases in pandemics by (1) using patients’ claims data from different counties and states that capture local disease status and medical resource utilization; (2) utilizing demographic similarity and geographical proximity between locations; and (3) integrating pandemic transmission dynamics into a deep learning model.

Materials and Methods
We proposed a spatio-temporal attention network (STAN) for pandemic prediction. It uses a graph attention network to capture spatio-temporal trends of disease dynamics and to predict the number of cases for a fixed number of days into the future. We also designed a dynamics-based loss term for enhancing long-term predictions. STAN was tested using both real-world patient claims data and COVID-19 statistics over time across US counties.

Results
STAN outperforms traditional epidemiological models such as susceptible-infectious-recovered (SIR), susceptible-exposed-infectious-recovered (SEIR), and deep learning models on both long-term and short-term predictions, achieving up to 87% reduction in mean squared error compared to the best baseline prediction model.

Conclusions
By combining information from real-world claims data and disease case counts data, STAN can better predict disease status and medical resource utilization.
The End of the Pāṇḍavas’ Year in Disguise
Authors: Brodbeck Simon 
Published: December 2020

Abstract
This article discusses an ambiguity in the Sanskrit Mahābhārata concerning whether or not the Pāṇḍavas maintained their disguises for a full year. It argues that the text uses this ambiguity in order to provide a psychologically realistic explanation for the war – the war that is mandated in advance as part of a divine plan to address the Earth’s reported afflictions, and that is ensured in real time by the actions of divinities in the form of human beings. The ambiguity at the end of the year in disguise makes a success of the text’s strategy of presenting a divine plan simultaneous with the human action. The article shows that both human sides – Duryodhana and Yudhiṣṭhira – adhere closely to the dharma of the covenant made at the second dicing match.
Discussion focuses on the recognition of Arjuna by the Kauravas in the Virāṭaparvan, and on the narrative effects of that recognition. Various characters’ perspectives on this recognition event are presented and examined. Bhīṣma says the year was already over, so the Pāṇḍavas are not accused of breaching the covenant. The second half of the article explores the implications of this as they unfold in the Udyogaparvan.
Long-Term Cause-Specific Mortality in Hodgkin Lymphoma Patients
Authors: de Vries Simone , Schaapveld Michael , Janus Cécile P M , Daniëls Laurien A , Petersen Eefke J , van der Maazen Richard W M , Zijlstra Josée M , Beijert Max , Nijziel Marten R , Verschueren Karijn M S , Kremer Leontien C M , van Eggermond Anna M , Lugtenburg Pieternella J , Krol Augustinus D G , Roesink Judith M , Plattel Wouter J , van Spronsen Dick Johan , van Imhoff Gustaaf W , de Boer Jan Paul , Aleman Berthe M P , van Leeuwen Flora E 
Published: December 2020

Abstract

Background
Few studies have examined the impact of treatment-related morbidity on long-term, cause-specific mortality in Hodgkin lymphoma (HL) patients.

Methods
This multicenter cohort included 4919 HL patients, treated before age 51 years between 1965 and 2000, with a median follow-up of 20.2 years. Standardized mortality ratios, absolute excess mortality (AEM) per 10 000 person-years, and cause-specific cumulative mortality by stage and primary treatment, accounting for competing risks, were calculated.

Results
HL patients experienced a 5.1-fold (AEM = 123 excess deaths per 10 000 person-years) higher risk of death due to causes other than HL. This risk remained increased in 40-year survivors (standardized mortality ratio = 5.2, 95% confidence interval [CI] = 4.2 to 6.5, AEM = 619). At age 54 years, HL survivors experienced similar cumulative mortality (20.0%) from causes other than HL to 71-year-old individuals from the general population. Whereas HL mortality statistically significantly decreased over the calendar period (P &lt; .001), solid tumor mortality did not change in the most recent treatment era. Patients treated in 1989-2000 had lower 25-year cardiovascular disease mortality than patients treated in 1965-1976 (4.3% vs 5.7%; subdistribution hazard ratio = 0.65, 95% CI = 0.46 to 0.93). Infectious disease mortality was not only increased after splenectomy but also after spleen irradiation (hazard ratio = 2.81, 95% CI = 1.55 to 5.07). For stage I-II, primary treatment with chemotherapy (CT) alone was associated with statistically significantly higher HL mortality (P &lt; .001 for CT vs radiotherapy [RT]; P = .04 for CT vs RT+CT) but lower 30-year mortality from causes other than HL (15.8%, 95% CI = 9.7% to 23.3%) compared with RT alone (36.9%, 95% CI = 34.0% to 39.8%, P = .001) and RT and CT combined (29.8%, 95% CI = 26.8% to 32.9%, P = .02).

Conclusions
Compared with the general population, HL survivors have a substantially reduced life expectancy. Optimal selection of patients for primary CT is crucial, weighing risks of HL relapse and long-term toxicity.
Seeing Red Through Rose-Colored Glasses: Subjective Hope as a Moderator of the Persuasive Influence of Anger
Authors: Walter Nathan , Demetriades Stefanie Z , Nabi Robin L 
Published: December 2020

AbstractResearch identifies contradictory effects of anger in political communication, engendering heuristic processing of information that exacerbates partisan bias in some situations, but increasing attention and deepening information processing in others. This study addressed these contradictions by positing subjective hope as a moderator of anger’s effects on message processing and persuasion. Employing an experimental design (N = 538) in the context of the U.S. immigration debate, the study assessed two long-standing mechanisms associated with the persuasive effects of anger—psychological reactance and message elaboration—with subjective hope as a moderator of those processes. Results confirmed that experienced anger increases reactance and superficial information processing. Critically, however, subjective hope emerged as a key moderator capable of reversing anger’s negative effects. These findings offer an important clarification of the boundary conditions governing the effects of anger and highlight the need for further study of interacting emotional processes in political communication.
The inverse relationship between solar-induced fluorescence yield and photosynthetic capacity: benefits for field phenotyping
Authors: Fu Peng , Meacham-Hensold Katherine , Siebers Matthew H , Bernacchi Carl J 
Published: December 2020

AbstractImproving photosynthesis is considered a promising way to increase crop yield to feed a growing population. Realizing this goal requires non-destructive techniques to quantify photosynthetic variation among crop cultivars. Despite existing remote sensing-based approaches, it remains a question whether solar-induced fluorescence (SIF) can facilitate screening crop cultivars of improved photosynthetic capacity in plant breeding trials. Here we tested a hypothesis that SIF yield rather than SIF had a better relationship with the maximum electron transport rate (Jmax). Time-synchronized hyperspectral images and irradiance spectra of sunlight under clear-sky conditions were combined to estimate SIF and SIF yield, which were then correlated with ground-truth Vcmax and Jmax. With observations binned over time (i.e. group 1: 6, 7, and 12 July 2017; group 2: 31 July and 18 August 2017; and group 3: 24 and 25 July 2018), SIF yield showed a stronger negative relationship, compared with SIF, with photosynthetic variables. Using SIF yield for Jmax (Vcmax) predictions, the regression analysis exhibited an R2 of 0.62 (0.71) and root mean square error (RMSE) of 11.88 (46.86) μmol m–2 s–1 for group 1, an R2 of 0.85 (0.72) and RMSE of 13.51 (49.32) μmol m–2 s–1 for group 2, and an R2 of 0.92 (0.87) and RMSE of 15.23 (30.29) μmol m–2 s–1 for group 3. The combined use of hyperspectral images and irradiance measurements provides an alternative yet promising approach to characterization of photosynthetic parameters at plot level.