bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal pelvis and ureteropelvic junction incarceration in a Grynfeltt-Lesshaft hernia: a case report and review of the literature
Authors: Mehrabi Saadat , Yavari Barhaghtalab Mohammad Javad , Babapour Mehdi 
Published: June 2020

Abstract
Background
Grynfeltt–Lesshaft hernia is a kind of lumbar abdominal wall hernia in which clinical presentations may vary from an asymptomatic bulge in the lumbar area to a symptomatic lumbar mass with back pain. It has been accepted to be a rare entity, and incarceration of the kidney through this hernia is shown to be very rare, and very few previous cases have been reported in this regard.
We present a case of renal pelvic and ureteropelvic junction incarceration in a Grynfeltt-Lesshaft hernia and provide an overview of the existing literature on it.

Case presentation
A 76-year-old lady presented to the outpatient clinic with the chief complaint of right flank pain and swelling. Computed tomography (CT) scan of the abdomen was revealed a large herniated sac (60*30 mm) in the upper lumbar triangle with protrusion of retroperitoneal and omental fat, right renal pelvis, ureteropelvic junction and proximal ureter with consecutive hydronephrosis. Herniated retroperitoneal and omental fat was reduced, and closure of the abdominal wall defect was done using retro-muscular Mesh and was fixed to the fascia. The patient was discharged 24 h after the surgery without any complications.

Conclusion
Kidney herniation through the lumbar triangle is extremely rare, and the diagnosis requires careful clinical evaluation. CT scan is the modality of choice for the assessment. Management through surgery should be done in symptomatic patients.
State-dependent mortality can enhance behavioral unpredictability
Authors: Okuyama Toshinori 
Published: June 2020

AbstractBackgroundAlthough behavioral unpredictability is widely described within-individual variability in behavior, its adaptive significance is little understood. Using a dynamic state variable model, this study investigated the conditions under which behavioral unpredictability (a component of within-individual variability) in foraging behavior is advantageous. The model considers a situation in which a forager forages for a fixed period, represented by discrete time steps. The outcome of foraging may change the level of a state (e.g., size and fat storage) of the forager at each time step, and variability in the foraging outcome is assumed to be positively correlated with behavioral unpredictability. The probability of death at each time step is influenced by the state at the same time step. Reproduction occurs after all the foraging steps and is influenced by the state level of a forager at the time of reproduction. According to the expected utility hypothesis, the relationship (e.g., curvature) between the state and fitness will determine the role of behavioral unpredictability. In the model, the relationship was obtained by using the backward iteration method for each foraging time step.ResultsState-dependent mortality adds curvature to the relationship between the state and fitness, which makes the effect of behavioral unpredictability on fitness either positive or negative. This conclusion holds for any state-dependent mortality (i.e., as long as mortality is not independent of the state factor). Given that state-dependent mortality is commonly described, conditions that benefit behavioral unpredictability are likely also common.ConclusionsWhen mortality depends on a state that is influenced by behavior, conditions that favor behavioral unpredictability may become common. How behavioral unpredictability influences the variability of behavioral outcomes is as important as how it influences the expectation of behavioral outcomes when studying the adaptive significance of behavioral unpredictability.
A lipidome-wide association study of the lipoprotein insulin resistance index
Authors: Bagheri Minoo , Tiwari Hemant K. , Murillo Anarina L. , Al-Tobasei Rafet , Arnett Donna K. , Kind Tobias , Barupal Dinesh Kumar , Fan Sili , Fiehn Oliver , O’connell Jeff , Montasser May , Aslibekyan Stella , Irvin Marguerite R. 
Published: June 2020

AbstractBackgroundThe lipoprotein insulin resistance (LPIR) score was shown to predict insulin resistance (IR) and type 2 diabetes (T2D) in healthy adults. However, the molecular basis underlying the LPIR utility for classification remains unclear.ObjectiveTo identify small molecule lipids associated with variation in the LPIR score, a weighted index of lipoproteins measured by nuclear magnetic resonance, in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 980).MethodsLinear mixed effects models were used to test the association between the LPIR score and 413 lipid species and their principal component analysis-derived groups. Significant associations were tested for replication with homeostatic model assessment-IR (HOMA-IR), a phenotype correlated with the LPIR score (r = 0.48,p <  0.001), in the Heredity and Phenotype Intervention (HAPI) Heart Study (n = 590).ResultsIn GOLDN, 319 lipids were associated with the LPIR score (false discovery rate-adjustedp-valuesranging from 4.59 × 10− 161to 49.50 × 10− 3). Factors 1 (triglycerides and diglycerides/storage lipids) and 3 (mixed lipids) were positively (β = 0.025,p = 4.52 × 10− 71and β = 0.021,p = 5.84 × 10− 41, respectively) and factor 2 (phospholipids/non-storage lipids) was inversely (β = − 0.013,p = 2.28 × 10− 18) associated with the LPIR score. These findings were replicated for HOMA-IR in the HAPI Heart Study (β = 0.10,p = 1.21 × 10− 02for storage, β = − 0.13,p = 3.14 × 10− 04for non-storage, and β = 0.19,p = 8.40 × 10− 07for mixed lipids).ConclusionsNon-storage lipidomics species show a significant inverse association with the LPIR metabolic dysfunction score and present a promising focus for future therapeutic and prevention studies.
Detecting and recording cardiac murmurs in clinically healthy puppies in first opinion veterinary practice at the first health check
Authors: van Staveren Marie Dirkje Beijken , Szatmári Viktor 
Published: June 2020

Abstract
Background
The frequency that cardiac murmurs are identified and recorded in first opinion veterinary practices at the first health check in puppies is unknown. The aims of the study were to assess the agreement between first opinion veterinary practitioners, a veterinary student and a veterinary cardiology specialist on detecting murmurs, and to establish whether abnormal auscultation findings had been recorded in the health certificates of clinically healthy puppies. The study included prospective and retrospective investigations, where the prospectively collected auscultation findings from a veterinary cardiology specialist and a trained veterinary student were compared to auscultation findings recorded by first opinion veterinary practitioners.

Results
Cardiac auscultation was performed on 331 client-owned, clinically healthy dogs at two time points: at age 34–69 days by a first opinion veterinary practitioner and at age 45–76 days, on average 9 days later, by a veterinary cardiology specialist and a trained veterinary student. Agreement among the three was compared for the presence of a murmur. The degree of inter-observer agreement was evaluated using Cohen’s kappa. Auscultation findings, as noted in the pets’ passports, from 331 puppies and 43 different first opinion veterinary practices, were retrospectively reviewed and prospectively compared with auscultation findings from a veterinary cardiology specialist. Agreement between the veterinary cardiology specialist and the first opinion veterinary practitioners was poor (ϰ = 0.01) and significantly different (P < 0.001). First opinion veterinary practitioners had recorded a cardiac murmur in only 1 of the 97 puppies in which the veterinary cardiology specialist detected a murmur. Two-hundred-and-fifty-two puppies were auscultated by both the veterinary cardiology specialist and the student. Their agreement was fair (ϰ = 0.40) and significantly different (P = 0.024). The agreement between the student and a first opinion veterinary practitioner on these 252 puppies was poor (ϰ = 0.03) and significantly different (P < 0.001).

Conclusions
This study shows that soft cardiac murmurs are rarely documented during the first veterinary health check in puppies by first opinion veterinary practitioners. Although soft murmurs may not be clinically relevant, finding and recording them is evidence of a carefully performed auscultation. Missing a non-pathological murmur is not of clinical importance; however, missing a pathological murmur could prove detrimental for the individual puppy.
Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial
Authors: Fan Dazhi , Zeng Meng , Xia Qing , Wu Shuzhen , Ye Shaoxin , Rao Jiaming , Lin Dongxin , Zhang Huishan , Ma Huiting , Han Zhongchao , Guo Xiaoling , Liu Zhengping 
Published: June 2020

Abstract
Background
Pathological skin scars, caused by cesarean section, affected younger mothers esthetically and psychosocially and to some extent frustrated obstetricians and dermatologists. Umbilical cord mesenchymal stem cells (UC-MSCs), as a population of multipotent cells, are abundant in human tissues, providing several possibilities for their effects on skin scar tissues. Herein, we performed a randomized, double-blind, placebo-controlled, three-arm clinical trial, aiming to assess the efficacy and safety of UC-MSCs in the treatment of cesarean section skin scars among primiparous singleton pregnant women.

Methods
Ninety primiparous singleton pregnant women undergoing elective cesarean section were randomly allocated to receive placebo, low-dose (3 × 106 cells), or high-dose (6 × 106 cells) transdermal hydrogel UC-MSCs on the surface of the skin incision. The primary outcome was cesarean section skin scars followed after the sixth month, assessed by the Vancouver Scar Scale (VSS).

Results
All the participants completed their trial of the primary outcome according to the protocol. The mean score of estimated total VSS was 5.52 in all participants at the sixth-month follow-up, with 6.43 in the placebo group, 5.18 in the low-dose group, and 4.71 in the high-dose group, respectively. No significant difference was found between-group in the mean scores for VSS at the sixth month. Additional prespecified secondary outcomes were not found with significant differences among groups either. No obvious side effects or adverse effects were reported in any of the three arms.

Conclusion
This randomized clinical trial showed that UC-MSCs did not demonstrate the effects of improvement of cesarean section skin scars.

Trial registration
ClinicalTrials.gov identifier, NCT02772289. Registered on 13 May 2016.
Measuring acceleration fields via regularized digital image correlation
Authors: Le Gourriérec Corentin , Roux Stéphane , Hild François 
Published: June 2020

AbstractDigital image correlation (DIC) is a full-field measurement technique. In instantaneous approaches (i.e., registering two images), DIC only gives access to displacement (or velocity) fields. Consequently, acceleration fields are not one of the primary measured variables. To evaluate acceleration fields, a regularization scheme has to be used. The latter may be either heuristic or mechanically motivated. The key idea of the paper is to use spatiotemporal analyses in order to explicitly measure acceleration fields. Various regularization schemes will be assessed, and their relative merits will be studied when performing uncertainty quantifications. Pyrotechnic cutting simulations will provide a set of artificial pictures to be studied in order to validate the new implementations. This analysis enables the measurement performances to be evaluated for the new implementations.
A “messy ball of wool”: a qualitative study of the dimensions of the lived experience of obesity
Authors: Ogden Kathryn , Barr Jenny , Rossetto Georgia , Mercer John 
Published: June 2020

Abstract
Background
Obesity is a multi-dimensional condition with causal factors beyond the physiological into the behavioural, dietetic and psychological. Understanding the lived experience of those who are overweight and obese and self-perceived barriers to access and engagement in intervention are imperative to formulating a systemic response to the complex problem of obesity. This study aims to identify the social, psychological and systemic factors impeding engagement with weight-loss behaviour and interventions, and to formulate a framework for responding to these.

Methods
We conducted an exploratory qualitative study using focus groups and interviews with people who have lived experienced of being overweight or obese. Data were analysed using an inductive thematic approach. Following the thematic analysis, further interpretation of the data was achieved by applying the epistemological foundations of the Lifeworld Led Care paradigm, recognising its philosophy of the person and of care based on the individual’s experiences. Eight men and 17 women participated.

Results
Three overarching themes were identified: Complexity and Battle, Impediments, and Positive Re-orientation. The subthemes of these were found to represent the dimensions of the Lifeworld: Identify, Inter-subjectivity, Mood and Embodiment.
Further interpretation of the themed data identified six polarised dichotomies representing the opposing lived dimensions of the obesity experience: Failure Double-Bind; Think-Feel Conflict; Negative-Positive Orientation; Impeding-Facilitating Health Professional; Knowledge as Deficit-Insight; and Internal-External Orientation.

Conclusion
Obesity manifests as constraints and challenges across six polarised dichotomies, active in the lived experience of obesity. This study provides a unique way of conceptualising and understanding the complex and interacting meanings of the lived experience of obesity through the construction of polarised dichotomies. The polarities signify the oscillating experiences that people with obesity encounter, which may be either helpful or destructive in both their lifeworld experience and their capacity to address obesity towards improved social, psychological and physical outcomes. Understanding the dichotomies allows a reconceptualisation of obesity from a quantification of the individual to a more respectful, humane, compassionate and utilitarian conceptualisation of the experiencing person and the phenomenon itself. Further, these lived polarised dichotomies of obesity present the opportunity for health professionals to reconceptualise obesity in care and interventions.
Immigration policy mismatches and counterproductive outcomes: unauthorized migration to the U.S. in two eras
Authors: Massey Douglas S. 
Published: June 2020

AbstractThe world appears to be moving into a new era of international migration during which gaps between policies needed to manage migratory flows and those enacted in practice will widen. Whereas immigrants in the late 20th century were motivated by a desire to improve their wellbeing by accessing opportunities in richer countries, in the early 21st century they are increasingly motivated by a desire to escape threats at places of origin, yielding very different patterns of migration and selectivity. Using the United States as an example, this paper reviews how mismatches between the underlying realities of international migration and the policies adopted to manage them, in both eras have produced and continue to produce dysfunctional outcomes. Although deleterious policy outcomes might be avoided in the future by combining a well-grounded conceptual understanding of the forces producing immigration with a clear statement of the goals to be achieved through specific policy interventions, the avoidance of further dysfunctional outcomes is unlikely to be achieved in an age of rising populism, disinformation, and xenophobia.
Parameters matter: modulating cytokines using nerve stimulation
Authors: Bonaz Bruno 
Published: June 2020

AbstractThe vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients with rheumatoid arthritis and inflammatory bowel disease have demonstrated the efficacy of targeting neural circuits as an efficient alternative to drug treatments. However, the optimal vagus nerve stimulation parameters to achieve efficacious symptomatic relief for inflammation are still unknown. In this issue of Bioelectronic Medicine, Tsaava et al. tested whether altering these electrical stimulation parameters would change circulating cytokine levels in healthy mice. They found that specific combinations of parameters produced significant increases in serum TNF while other parameters selectively lowered serum TNF levels, as compared to sham stimulated mice. These results have considerable implications for determining the optimal stimulation parameters to better treat common conditions and diseases that involve immune regulation.
Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression
Authors: Piercey Oliver A. , Loh Zoe , Chan Joanna , Chong Geoff , Grigg Andrew , Cheema Steven , Gill Gurjot , Whybird Matthew , Cushion Tania , Hawkes Eliza A. 
Published: June 2020

PURPOSE: Patients with indolent non-Hodgkin lymphoma (iNHL) undergo regular active surveillance in between treatment periods to detect disease relapse or progression. As part of surveillance, international guidelines recommend regular routine blood testing, which is based on consensus rather than evidence of utility. METHODS: We conducted a retrospective analysis of all patients older than age 16 years diagnosed with grade 1-3A follicular or marginal zone lymphoma between 2008 and 2017 from 2 Australian cancer centers to assess the utility of full blood examination, lactate dehydrogenase, and β2-microglobulin in detecting progression events, defined as either disease relapse or progression of disease. RESULTS: One hundred eighty patients attended 1,757 outpatient appointments (median follow-up, 36 months). Routine blood tests (RBTs) were performed before 83% of appointments. Seventy-four progression events occurred in 62 patients. Only 2 events (3%) were detected by RBTs alone, both of which occurred in treatment-naïve patients who subsequently developed symptoms within 3 weeks. The remainder of progression events were suspected clinically (88%) or detected by imaging (9%). RBT results were frequently abnormal in asymptomatic patients (19%), with abnormal results leading to either additional investigations or an increased surveillance frequency in 8% of cases. The overall sensitivity and positive predictive value of abnormal RBT results in detecting progression events were 39% and 9%, respectively. CONCLUSION: RBTs have poor performance characteristics and rarely detect clinically significant disease progression or relapse in asymptomatic patients with iNHL.
“Coyote Broke the Dams”: Power, Reciprocity, and Conflict in Fish Weir Narratives and Implications for Traditional and Contemporary Fisheries
Authors: Ritchie Morgan , Angelbeck Bill 
Published: June 2020

AbstractThis article examines the social and political implications of the geographically widespread and cross-cultural oral narratives related to the releases of salmon into the rivers of the Pacific Northwest through the destruction of weir-dams. Key themes in these narratives provide insights into indigenous concepts of reciprocity and authority, which in turn reveal dimensions of social organization and intercommunity interactions from a new perspective. These narratives explicitly foreground the inevitable tensions between communities that relied on salmon and also sought to prioritize their own interests, seeking exclusive use of weirs, occasionally to the detriment of other groups. This study illustrates how these narratives convey episodes of contradictory interests, exploitation, social struggle, reconciliation, and a moral charter for communities over a broad area. The analysis also highlights how the messages of these narratives are just as pertinent today as they were in the past.
An auxin transport network underlies xylem bridge formation between the hemi-parasitic plant Phtheirospermum japonicum and host Arabidopsis
Authors: Wakatake Takanori , Ogawa Satoshi , Yoshida Satoko , Shirasu Ken 
Published: June 2020

ABSTRACT
Parasitic plants form vascular connections with host plants for efficient material transport. The haustorium is the responsible organ for host invasion and subsequent vascular connection. After invasion of host tissues, vascular meristem-like cells emerge in the central region of the haustorium, differentiate into tracheary elements and establish a connection, known as a xylem bridge, between parasite and host xylem systems. Despite the importance of this parasitic connection, the regulatory mechanisms of xylem bridge formation are unknown. Here, we show the role of auxin and auxin transporters during the process of xylem bridge formation using an Orobanchaceae hemiparasitic plant, Phtheirospermum japonicum. The auxin response marker DR5 has a similar expression pattern to tracheary element differentiation genes in haustoria. Auxin transport inhibitors alter tracheary element differentiation in haustoria, but biosynthesis inhibitors do not, demonstrating the importance of auxin transport during xylem bridge formation. The expression patterns and subcellular localization of PIN family auxin efflux carriers and AUX1/LAX influx carriers correlate with DR5 expression patterns. The cooperative action of auxin transporters is therefore responsible for controlling xylem vessel connections between parasite and host.
Ensemble machine learning modeling for the prediction of artemisinin resistance in malaria
Authors: Ford Colby T. , Janies Daniel 
Published: June 2020

Resistance in malaria is a growing concern affecting many areas of Sub-Saharan Africa and Southeast Asia. Since the emergence of artemisinin resistance in the late 2000s in Cambodia, research into the underlying mechanisms has been underway. The 2019 Malaria Challenge posited the task of developing computational models that address important problems in advancing the fight against malaria. The first goal was to accurately predict artemisinin drug resistance levels of Plasmodium falciparum isolates, as quantified by the IC50. The second goal was to predict the parasite clearance rate of malaria parasite isolates based on in vitro transcriptional profiles. In this work, we develop machine learning models using novel methods for transforming isolate data and handling the tens of thousands of variables that result from these data transformation exercises. This is demonstrated by using massively parallel processing of the data vectorization for use in scalable machine learning. In addition, we show the utility of ensemble machine learning modeling for highly effective predictions of both goals of this challenge. This is demonstrated by the use of multiple machine learning algorithms combined with various scaling and normalization preprocessing steps. Then, using a voting ensemble, multiple models are combined to generate a final model prediction.