bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Time Asymmetries in Jupiter's Magnetodisc Currents
Authors: Lorch C. T. S. , Ray L. C. , Arridge C. S. , Khurana K. K. , Martin C. J. , Bader A. 
Published: February 2020

AbstractWe present an investigation into the currents within the Jovian magnetodisc using all available spacecraft magnetometer data up until 28 July 2018. Using automated data analysis processes as well as the most recent intrinsic field and current disk geometry models, a full local time coverage of the magnetodisc currents using 7,382 lobe traversals over 39 years is constructed. Our study demonstrates clear local time asymmetries in both the radial and azimuthal height‐integrated current densities throughout the current disk. Asymmetries persist within 30 R
where most models assume axisymmetry. Inward radial currents are found in the previously unmapped dusk and noon sectors. Azimuthal currents are found to be weaker in the dayside magnetosphere than the nightside, in agreement with global magnetohydrodynamic simulations. The divergence of the azimuthal and radial currents indicates that downward field‐aligned currents exist within the outer dayside magnetosphere. The presence of azimuthal currents is shown to highly influence the location of the field‐aligned currents, which emphasizes the importance of the azimuthal currents in future magnetosphere‐ionosphere coupling models. Integrating the divergence of the height‐integrated current densities, we find that 1.87 MA R
of return current density required for system closure is absent.
Tracking Counterpart Signatures in Saturn's Auroras and ENA Imagery During Large‐Scale Plasma Injection Events
Authors: Kinrade J. , Badman S. V. , Paranicas C. , Mitchell D. G. , Arridge C. S. , Gray R. L. , Bader A. , Provan G. , Cowley S. W. H. , Martin C. J. , Achilleos N. 
Published: February 2020

AbstractSaturn's morningside auroras consist mainly of rotating, transient emission patches, following periodic reconnection in the magnetotail. Simultaneous responses in global energetic neutral atom (ENA) emissions have been observed at similar local times, suggesting a link between the auroras and large‐scale injections of hot ions in the outer magnetosphere. In this study, we use Cassini's remote sensing instruments to observe multiple plasma injection signatures within coincident auroral and ENA imagery, captured during 9 April 2014. Kilometric radio emissions also indicate clear injection activity. We track the motion of rotating signatures in the auroras and ENAs to test their local time relationship. Two successive auroral signatures—separated by ~4 hr UT—form postmidnight before rotating to the dayside while moving equatorward. The first has a clear ENA counterpart, maintaining a similar local time mapping throughout ~9 hr observation. Mapping of the ionospheric equatorward motion post‐dawn indicates a factor ~5 reduction of the magnetospheric source region's radial speed at a distance of ~14‐20 RS, possibly a plasma or magnetic boundary. The second auroral signature has no clear ENA counterpart; viewing geometry was relatively unchanged, so the ENAs were likely too weak to detect by this time. A third, older injection signature, seen in both auroral and ENA imagery on the nightside, may have been sustained by field‐aligned currents linked with the southern planetary period oscillation system, or the re‐energization of ENAs around midnight local times. The ENA injection signatures form near magnetic longitudes associated with magnetotail thinning.
Pitch Angle Dependence of Electron and Ion Flux Changes During Local Magnetic Dipolarization Inside Geosynchronous Orbit
Authors: Motoba T. , Ohtani S. , Gkioulidou M. , Mitchell D. G. , Ukhorskiy A. Y. , Takahashi K. , Lanzerotti L. J. , Claudepierre S.G. , Spence H. E. , Reeves G. D. 
Published: February 2020

AbstractIn this study we have statistically examined flux changes of 1–1,000‐keV electrons, and hydrogen, helium, and oxygen ions during local magnetic dipolarization inside geosynchronous orbit, with a focus on their pitch angle dependence. Using 144 dipolarization events that were selected in a previous study with Van Allen Probes observations in 2012–2016, we have performed a superposed epoch analysis of differential flux changes after the dipolarization onset for each species. On average the electron flux increases primarily around pitch angle (α) = 90° at >80 keV and almost isotropically at 10–50 keV. The electron flux at <5 keV increases at α = 0° and 180° but slightly decreases (or remains unchanged) at α = 90°. On the other hand, the ion flux at >80 keV increases around α = 90°, while at <30 keV it decreases nearly independent of pitch angle. Only the low‐energy (<5 keV) helium and oxygen ion flux changes indicate a strong field‐aligned enhancement, which could be attributed to their outflows from the topside ionosphere. After the dipolarization onset, >5‐keV electron and >30‐keV ion fluxes exhibit a perpendicular anisotropy, which is most pronounced for 50–200‐keV electrons. Both distributions become more isotropic with decreasing energy. A noticeable field‐aligned anisotropy is seen for <5‐keV ion fluxes. These statistical pitch angle‐dependent electron and ion properties during dipolarizations may be explained by combining various processes, including adiabatic acceleration and/or transport, wave‐particle interactions, and ion outflow.
Global Assimilation of Ocean‐Color Data of Phytoplankton Functional Types: Impact of Different Data Sets
Authors: Pradhan H. K. , Völker C. , Losa S. N. , Bracher A. , Nerger L. 
Published: February 2020

AbstractPhytoplankton functional‐type (PFT) data are assimilated into the global coupled ocean‐ecosystem model MITgcm‐REcoM2 for two years using a local ensemble Kalman filter. The ecosystem model has two PFTs: small phytoplankton (SP) and diatoms. Three different sets of satellite PFT data are assimilated: Ocean‐Color‐Phytoplankton Functional Type (OC‐PFT), Phytoplankton Differential Optical Absorption Spectroscopy (PhytoDOAS), and SYNergistic exploitation of hyper‐ and multi‐spectral precursor SENtinel measurements to determine Phytoplankton Functional Types (SynSenPFT), which is a synergistic product combining the independent PFT products OC‐PFT and PhytoDOAS. The effect of assimilating PFT data is compared with the assimilation of total chlorophyll data (TChla), which constrains both PFTs through multivariate assimilation. While the assimilation of TChla already improves both PFTs, the assimilation of PFT data further improves the representation of the phytoplankton community. The effect is particularly large for diatoms where, compared to the assimilation of TChla, the SynSenPFT assimilation results in 57% and 67% reduction of root‐mean‐square error and bias, respectively, while the correlation is increased from 0.45 to 0.54. For SP the assimilation of SynSenPFT data reduces the root‐mean‐square error and bias by 14% each and increases the correlation by 30%. The separate assimilation of the PFT data products OC‐PFT, SynSenPFT, and joint assimilation of OC‐PFT and PhytoDOAS data leads to similar results while the assimilation of PhytoDOAS data alone leads to deteriorated SP but improved diatoms. When both OC‐PFT and PhytoDOAS data are jointly assimilated, the representation of diatoms is improved compared to the assimilation of only OC‐PFT. The results show slightly lower errors than when the synergistic SynSenPFT data are assimilated, which shows that the assimilation successfully combines the separate data sources.
The Role of Englacial Hydrology in the Filling and Drainage of an Ice‐Dammed Lake, Kaskawulsh Glacier, Yukon, Canada
Authors: Bigelow David G. , Flowers Gwenn E. , Schoof Christian G. , Mingo Laurent D. B. , Young Erik M. , Connal Braden G. 
Published: February 2020

Outburst floods from ice‐marginal lakes are poised to become more prevalent in a warming climate. As glaciers thin and tributaries detach, water can be impounded in these unstable lakes at valley confluences. To characterize the role of the little‐studied englacial hydrological system during an outburst flood cycle, we deployed a variety of geophysical and hydrometeorological instruments in and around an ice‐marginal lake dammed by the Kaskawulsh Glacier, Yukon, Canada, to capture its 2017 filling and drainage. The subaerial lake reached a maximum volume of 9.9
m
on 17 August before draining over the course of
19 days. During lake filling, abrupt changes in ice shelf uplift rates are associated with the formation of faults and fractures. These hydromechanical interactions are closely linked to a redistribution of englacial water as evidenced by fluctuations in shallow borehole water pressures, and changes in radar internal reflection power. Water balance calculations reveal that the subaerial, subglacial, and englacial reservoirs respectively store 20 (17–23)%, 40 (25–50)%, and 40 (30–60)% of water in the catchment at peak lake level. The calculated englacial storage volume implies saturated porosities up to 4–10% locally or 2–4% catchment‐wide. The englacial system is therefore both volumetrically important and influenced by the hydromechanical interactions between the lake and glacier. Its spatial extent and storage capacity may play a role in lake drainage initiation, modulation of the flood hydrograph, and lake refilling.
Present‐Day Greenland Ice Sheet Climate and Surface Mass Balance in CESM2
Authors: van Kampenhout Leonardus , Lenaerts Jan T. M. , Lipscomb William H. , Lhermitte Stef , Noël Brice , Vizcaíno Miren , Sacks William J. , van den Broeke Michiel R. 
Published: February 2020

The response of the Greenland Ice Sheet (GrIS) to a warmer climate is uncertain on long time scales. Climate models, such as those participating in the Coupled Model Intercomparison Project phase 6 (CMIP6), are used to assess this uncertainty. The Community Earth System Model version 2.1 (CESM2) is a CMIP6 model capable of running climate simulations with either one‐way coupling (fixed ice sheet geometry) or two‐way coupling (dynamic geometry) to the GrIS. The model features prognostic snow albedo, online downscaling using elevation classes, and a firn pack to refreeze percolating melt water. Here we evaluate the representation of the GrIS surface energy balance and surface mass balance in CESM2 at 1° resolution with fixed GrIS geometry. CESM2 agrees closely with ERA‐Interim reanalysis data for key controls on GrIS SMB: surface pressure, sea ice extent, 500 hPa geopotential height, wind speed, and 700 hPa air temperature. Cloudsat‐CALIPSO data show that supercooled liquid‐containing clouds are adequately represented, whereas comparisons to Moderate Resolution Imaging Spectroradiometer and CM SAF Cloud, Albedo, and Surface Radiation data set from Advanced Very High Resolution Radiometer data second edition data suggest that CESM2 underestimates surface albedo. The seasonal cycle and spatial patterns of surface energy balance and surface mass balance components in CESM2 agree well with regional climate model RACMO2.3p2, with GrIS‐integrated melt, refreezing, and runoff bracketed by RACMO2 counterparts at 11 and 1 km. Time series of melt, runoff, and SMB show a break point around 1990, similar to RACMO2. These results suggest that GrIS SMB is realistic in CESM2, which adds confidence to coupled ice sheet‐climate experiments that aim to assess the GrIS contribution to future sea level rise.
A Sediment Trap Evaluation of B/Ca as a Carbonate System Proxy in Asymbiotic and Nondinoflagellate Hosting Planktonic Foraminifera
Authors: Osborne Emily B. , Umling Natalie E. , Bizimis Michael , Buckley Wayne , Sadekov Aleksey , Tappa Eric , Marshall Brittney , Sautter Leslie R. , Thunell Robert C. 
Published: February 2020

AbstractThe ratio of boron to calcium (B/Ca) in a subset of foraminifera has been shown to covary with seawater carbonate chemistry, making this geochemical signature a promising proxy for carbon cycle science. Some studies suggest complications with the B/Ca proxy in photosymbiont‐bearing planktonic foraminifera, while relatively few studies have investigated B/Ca in species that lack large dinoflagellate symbionts. For the first time, we use a sediment trap time series to evaluate B/Ca of subtropical and subpolar planktonic foraminifera species that are asymbiotic (Globigerina bulloides and Neogloboquadrina incompta) and a species that hosts small intrashell photosymbionts (Neogloboquadrina dutertrei). We find that B/Ca measurements across size fractions indicate overall little to no size‐dependent uptake of boron that has previously been reported in some symbiont‐bearing foraminifera. Neogloboquadrina incompta and N. dutertrei B/Ca are strongly correlated with calcite saturation, pH, and carbonate ion concentration, which is in good agreement with the limited number of published core top results. While G. bulloides B/Ca trends with seasonal fluctuations in carbonate chemistry, during discrete periods considerable B/Ca offsets occur when a cryptic G. bulloides species is known to be seasonally present within the region. We confirm presence and significant B/Ca offset between cryptic species by individual LA‐ICP‐MS analyses. This finding calls into question the use of traditional morphological classification to lump what might be genetically distinct species for geochemical analyses. Our overall results highlight the utility of G. bulloides, N. incompta, and N. dutertrei B/Ca while bringing to light new considerations regarding divergent geochemistry of cryptic species.
Orogen‐Parallel Transition From a Decoupled Fore‐Arc Sliver to Andean‐Type Mountain Chain: Paleomagnetic and Geologic Evidence From Southern Chile (37–39°S)
Authors: Siravo Gaia , Speranza Fabio , Hernandez‐Moreno Catalina , Di Chiara Anita 
Published: February 2020

AbstractThe Chiloé fore‐arc sliver is an approximately N‐S elongated crust block detached from South America along the dextral intra‐arc Liquiñe‐Ofqui fault zone (LOFZ). The sliver is internally dissected by active NW‐SE sinistral faults whose relations with the LOFZ are speculative, also due to widespread fluvioglacial and volcanic blanket hiding the substratum. We focus on the northern LOFZ end and on the Biobio fault, supposedly the northernmost of the sinistral fault set, reporting on the results from field investigation and paleomagnetism of 48 (mostly Oligo‐Miocene) volcanic sites. We find that the Biobio fault is an old inherited crust discontinuity that did not yield significant block rotation and deformation during the Cenozoic, thus testifying the end of sinistral shear at about 38°S. At the same latitudes, a northward transition from pure strike‐slip to transpressive LOFZ deformation occurs. Intense tectonic deformation and >90° clockwise rotations characterize the main LOFZ strand. Conversely, a supposedly western LOFZ strand displays counterclockwise rotations, similar to the pattern previously documented in the forearc; thus, it does not represent a LOFZ segment. LOFZ and sinistral fault kinematics must be related, and we suggest that crust pushed northward west of the LOFZ escapes laterally toward the trench along the sinistral faults. We also speculate that the northward increasing age of the subducting Nazca plate implies a concomitant decrease of heat transfer on the upper plate, thus an increasing crust rigidity that eventually inhibits strain partitioning and sliver decoupling from 38°S.
Tailoring Infographics on Water Resources Through Iterative, User‐Centered Design: A Case Study in the Peruvian Andes
Authors: Grainger Sam , Ochoa‐Tocachi Boris F. , Antiporta Javier , Dewulf Art , Buytaert Wouter 
Published: February 2020

AbstractEffective communication and knowledge sharing across stakeholder groups (e.g., science, government, business, civil society, farmers, and the general public) are essential for more informed water resource management. Visualizations and graphics are powerful tools to engage diverse groups with unfamiliar information. Despite this potential, the design of visuals within applied science settings often does not involve end‐user interaction or explicit consideration of their existing knowledge systems, perspective, requirements, and context of use. As a result, products are often difficult for users to understand and contextualize. While user interaction and the development of tailored visualizations is increasingly promoted as a potential remedy, limited empirical evidence exists that shows the potential impact and can guide the development of specific approaches. We piloted an iterative and user‐centered design methodology toward the tailoring of infographic‐style posters in the context of Peruvian water governance. To test whether tailoring demonstrably improves the perceived effectiveness of products, we designed three products that conveyed similar information but were tailored to three different audiences (an Andean agricultural, urban professional, and urban general). We then compared the tailored posters to those tailored to other audiences by means of interviews and user grading. We found that end‐users perceive products that have undergone tailoring as more interesting, clearer, and more useful than products designed without explicit user consideration. Our findings indicate that identifying groups with shared characteristics and requirements is key for effective tailoring. Our research provides empirical evidence to support the incorporation of user‐centered design methods in water resource management contexts.
DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells
Authors: Bera Rabindranath , Chiu Ming-Chun , Huang Ying-Jung , Huang Gang , Lee Yun-Shien , Shih Lee-Yung 
Published: February 2020

AbstractAcute myeloid leukemia (AML) with partial tandem duplication of histone-lysine N-methyltransferase 2A (KMT2A-PTD) is a subtype of AML and is associated with adverse survival, yet the molecular pathogenesis of KMT2A-PTD is not fully understood. DNA methyltransferase 3A (DNMT3A) is mutated in various myeloid neoplasms including AML, especially at the Arg882. Recently, it has been found that DNMT3A mutations frequently coexisted with KMT2A-PTD and are associated with inferior outcomes. We aimed to understand the biological role of DNMT3A mutation in KMT2A-PTD-positive cells. Herein, we found that overexpression of DNMT3A mutants (MT) in KMT2A-PTD-positive EOL-1 cells augmented cell proliferation and clonogenicity. Serial colony replating assays indicated that DNMT3A-MT increased the self-renewal ability of Kmt2a-PTD-expressing mouse bone marrow cells with immature morphology. At 10 months post bone marrow transplantation, mice with the combined Kmt2a-PTD and DNMT3A-MT showed hepatosplenomegaly and leukocytosis with a shorter latency compared to control and DNMT3A-wild-type. Gene expression microarray analyses of bone marrow samples from human AML with KMT2A-PTD/DNMT3A-MT showed a stem cell signature and myeloid hematopoietic lineage with dysregulation of HOXB gene expression. In addition, human bone marrow AML cells carrying KMT2A-PTD/DNMT3A-MT showed abnormal growth and augmented self-renewal activity in primary cell culture. The present study provides information underlying the pathogenic role of DNMT3A-MT with KMT2A-PTD in proliferating advantage with augmentation of self-renewal activity in human leukemia, which may help to better understand the disease and to design better therapy for AML patients with these mutations.
PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay
Authors: Su Rui , Ma Jun , Zheng Jian , Liu Xiaobai , Liu Yunhui , Ruan Xuelei , Shen Shuyuan , Yang Chunqing , Wang Di , Cai Heng , Li Zhen , Xue Yixue 
Published: February 2020

AbstractGlioblastoma is the most common and malignant form of primary central nervous tumor in adults. Long noncoding RNAs (lncRNAs) have been reported to play a pivotal role in modulating gene expression and regulating human tumor’s malignant behaviors. In this study, we confirmed that lncRNA brain-derived neurotrophic factor antisense (BDNF-AS) was downregulated in glioblastoma tissues and cells, interacted and stabilized by polyadenylate-binding protein cytoplasmic 1 (PABPC1). Overexpression of BDNF-AS inhibited the proliferation, migration, and invasion, as well as induced the apoptosis of glioblastoma cells. In the in vivo study, PABPC1 overexpression combined with BDNF-AS overexpression produced the smallest tumor and the longest survival. Moreover, BDNF-AS could elicit retina and anterior neural fold homeobox 2 (RAX2) mRNA decay through STAU1-mediated decay (SMD), and thereby regulated the malignant behaviors glioblastoma cells. Knockdown of RAX2 produced tumor-suppressive function in glioblastoma cells and increased the expression of discs large homolog 5 (DLG5), leading to the activation of the Hippo pathway. In general, this study elucidated that the PABPC1-BDNF-AS-RAX2-DLG5 mechanism may contribute to the anticancer potential of glioma cells and may provide potential therapeutic targets for human glioma.
Alpha-synuclein fragments trigger distinct aggregation pathways
Authors: Chakroun Tasnim , Evsyukov Valentin , Nykänen Niko-Petteri , Höllerhage Matthias , Schmidt Andreas , Kamp Frits , Ruf Viktoria C. , Wurst Wolfgang , Rösler Thomas W. , Höglinger Günter U. 
Published: February 2020

AbstractAggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate therapeutic target. Hence, to develop efficient disease-modifying strategies, it is fundamental to achieve a deeper understanding of the relevant spreading and toxic αSyn species. Here, we describe comparative and proof-of-principle approaches to determine the involvement of αSyn fragments in intercellular spreading. We demonstrate that two different αSyn fragments (1–95 and 61–140) fulfill the criteria of spreading species. They efficiently instigate formation of proteinase-K-resistant aggregates from cell-endogenous full-length αSyn, and drive it into different aggregation pathways. The resulting aggregates induce cellular toxicity. Strikingly, these aggregates are only detectable by specific antibodies. Our results suggest that αSyn fragments might be relevant not only for spreading, but also for aggregation-fate determination and differential strain formation.