bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
Authors: Tamtaji Omid Reza , Behnam Mohammad , Pourattar Mohammad Ali , Hamblin Michael R. , Mahjoubin-Tehran Maryam , Mirzaei Hamed , Asemi Zatollah 
Published: October 2020

AbstractGlioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma.
Efficacy of the ‘Stand and Move at Work’ multicomponent workplace intervention to reduce sedentary time and improve cardiometabolic risk: a group randomized clinical trial
Authors: Pereira Mark A. , Mullane Sarah L. , Toledo Meynard John Lapore , Larouche Miranda L. , Rydell Sarah A. , Vuong Brenna , Feltes Linda H. , Mitchell Nathan R. , de Brito Junia N. , Hasanaj Kristina , Carlson Neil G. , Gaesser Glenn A. , Crespo Noe C. , Oakes J. Michael , Buman Matthew P. 
Published: October 2020

Abstract
Background
Sedentary time is associated with chronic disease and premature mortality. We tested a multilevel workplace intervention with and without sit-stand workstations to reduce sedentary time and lower cardiometabolic risk.

Methods
Stand and Move at Work was a group (cluster) randomized trial conducted between January 2016 and December 2017 among full-time employees; ≥18 years; and in academic, industry/healthcare, and government worksites in Phoenix, Arizona and Minneapolis/St. Paul, Minnesota, USA. Eligible worksites were randomized to (a) MOVE+, a multilevel intervention targeting reduction in sedentary time and increases in light physical activity (LPA); or (b) STAND+, the MOVE+ intervention along with sit-stand workstations to allow employees to sit or stand while working. The primary endpoints were objectively-measured workplace sitting and LPA at 12 months. The secondary endpoint was a clustered cardiometabolic risk score (blood pressure, glucose, insulin, triglycerides, and HDL-cholesterol) at 12 months.

Results
Worksites (N = 24; academic [n = 8], industry/healthcare [n = 8], and government [n = 8] sectors) and employees (N = 630; 27 ± 8 per worksite; 45 ± 11 years of age, 74% female) were enrolled. All worksites were retained and 487 participants completed the intervention and provided data for the primary endpoint. The adjusted between arm difference in sitting at 12 months was − 59.2 (CI: − 74.6,-43.8) min per 8 h workday, favoring STAND+, and in LPA at 12 months was + 2.2 (− 0.9,5.4) min per 8 h workday. Change in the clustered metabolic risk score was small and not statistically significant, but favored STAND+. In an exploratory subgroup of 95 participants with prediabetes or diabetes, the effect sizes were larger and clinically meaningful, all favoring STAND+, including blood glucose, triglycerides, systolic blood pressure, glycated hemoglobin, LDL-cholesterol, body weight, and body fat.

Conclusions
Multilevel workplace interventions that include the use of sit-stand workstations are effective for large reductions in sitting time over 12 months. Among those with prediabetes or diabetes, clinical improvements in cardiometabolic risk factors and body weight may be realized.

Trial registration
ClinicalTrials.gov Identifier: NCT02566317. Registered 2 October 2015, first participant enrolled 11 January 2016.
The psychological typhoon eye effect during the COVID-19 outbreak in China: the role of coping efficacy and perceived threat
Authors: Zhang Li , Ma Min , Li Danfeng , Xin Ziqiang 
Published: October 2020

AbstractBackgroundThe influence of COVID-19 on mental health problems has received considerable attention. However, only a few studies have examined the relationship between exposure to COVID-19 and mental health problems, and no empirical study has tested the mechanisms between them.MethodsWe conducted a survey in 31 provinces of China during 3–13 March 2020 to test the effect of the exposure level on mental health problems. Our sample comprised 2987 participants who reported their perceived threat, coping efficacy, mental health problems and other demographic variables. Multiple mediators path analysis was used in the data analysis.ResultsThe results showed that the level of exposure to COVID-19 in China was negatively associated with mental health problems, which confirmed the “Psychological Typhoon Eye” effect. Further analyses indicated that both perceived threat and coping efficacy partially mediated the relationship between them. However, coping efficacy explained the “Psychological Typhoon Eye” effect. Perceived threat mediated the positive relationship between exposure level and mental health problems.ConclusionThis study detected the psychological typhoon eye effect and demonstrated the mediating role of coping efficacy and perceived threat between exposure to COVID-19 and mental health problems. Our findings suggest that policy makers and psychological workers should provide enough psychological services to low-risk areas as the high-risk areas. An important means of alleviating mental health problems is to improve coping efficacy.
Rapid metabolite response in leaf blade and petiole as a marker for shade avoidance syndrome
Authors: Sng Benny Jian Rong , Singh Gajendra Pratap , Van Vu Kien , Chua Nam-Hai , Ram Rajeev J. , Jang In-Cheol 
Published: October 2020

Abstract
Background
Shade avoidance syndrome (SAS) commonly occurs in plants experiencing vegetative shade, causing morphological and physiological changes that are detrimental to plant health and consequently crop yield. As the effects of SAS on plants are irreversible, early detection of SAS in plants is critical for sustainable agriculture. However, conventional methods to assess SAS are restricted to observing for morphological changes and checking the expression of shade-induced genes after homogenization of plant tissues, which makes it difficult to detect SAS early.

Results
Using the model plant Arabidopsis thaliana, we introduced the use of Raman spectroscopy to measure shade-induced changes of metabolites in vivo. Raman spectroscopy detected a decrease in carotenoid contents in leaf blades and petioles of plants with SAS, which were induced by low Red:Far-red light ratio or high density conditions. Moreover, by measuring the carotenoid Raman peaks, we were able to show that the reduction in carotenoid content under shade was mediated by phytochrome signaling. Carotenoid Raman peaks showed more remarkable response to SAS in petioles than leaf blades of plants, which greatly corresponded to their morphological response under shade or high plant density. Most importantly, carotenoid content decreased shortly after shade induction but before the occurrence of visible morphological changes. We demonstrated this finding to be similar in other plant species. Comprehensive testing of Brassica vegetables showed that carotenoid content decreased during SAS, in both shade and high density conditions. Likewise, carotenoid content responded quickly to shade, in a manner similar to Arabidopsis plants.

Conclusions
In various plant species tested in this study, quantification of carotenoid Raman peaks correlate to the severity of SAS. Moreover, short-term exposure to shade can induce the carotenoid Raman peaks to decrease. These findings highlight the carotenoid Raman peaks as a biomarker for early diagnosis of SAS in plants.
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation
Authors: Li Tiansheng , Mao Chao , Wang Xiang , Shi Ying , Tao Yongguang 
Published: October 2020

AbstractHypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However, in hypoxic conditions, HIF-α is activated and stabilized, and HIF target genes are successively activated, resulting in a series of tumour-specific activities. The activation of HIFs, including HIF-1α, HIF-2α and HIF-3α, subsequently induce downstream target genes which leads to series of responses, the resulting abnormal processes or metabolites in turn affect HIFs stability. Given its functions in tumors progression, HIFs have been regarded as therapeutic targets for improved treatment efficacy. Epigenetics refers to alterations in gene expression that are stable between cell divisions, and sometimes between generations, but do not involve changes in the underlying DNA sequence of the organism. And with the development of research, epigenetic regulation has been found to play an important role in the development of tumors, which providing accumulating basic or clinical evidences for tumor treatments. Here, given how little has been reported about the overall association between hypoxic tumors and epigenetics, we made a more systematic review from epigenetic perspective in hope of helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors.
Prevalence of germline BRCA mutations in HER2-negative metastatic breast cancer: global results from the real-world, observational BREAKOUT study
Authors: O’Shaughnessy Joyce , Brezden-Masley Christine , Cazzaniga Marina , Dalvi Tapashi , Walker Graham , Bennett James , Ohsumi Shozo 
Published: October 2020

AbstractBackgroundThe global observational BREAKOUT study investigated germlineBRCAmutation (gBRCAm) prevalence in a population of patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC).MethodsEligible patients had initiated first-line cytotoxic chemotherapy for HER2-negative MBC within 90 days prior to enrollment. Hormone receptor (HR)-positive patients had experienced disease progression on or after prior endocrine therapy, or endocrine therapy was considered unsuitable. gBRCAm status was determined using baseline blood samples or prior germline test results. For patients with a negative gBRCAm test, archival tissue was tested for somatic BRCAm and homologous recombination repair mutations (HRRm). Details of first-line cytotoxic chemotherapy were also collected.ResultsBetween March 2017 and April 2018, 384 patients from 14 countries were screened and consented to study enrollment; 341 patients were included in the full analysis set (median [range] age at enrollment: 56 [25–89] years; 256 (75.3%) postmenopausal). Overall, 33 patients (9.7%) had a gBRCAm (16 [4.7%] in gBRCA1only, 12 [3.5%] in gBRCA2only, and 5 [1.5%] in both gBRCA1and gBRCA2). gBRCAm prevalence was similar in HR-positive and HR-negative patients. gBRCAm prevalence was 9.0% in European patients and 10.6% in Asian patients and was higher in patients aged ≤ 50 years at initial breast cancer (BC) diagnosis (12.9%) than patients aged > 50 years (5.4%). In patients with any risk factor for having a gBRCAm (family history of BC and/or ovarian cancer, aged ≤ 50 years at initial BC diagnosis, or triple-negative BC), prevalence was 10.4%, versus 5.8% in patients without these risk factors. HRRm prevalence was 14.1% (n = 9/64) in patients with germlineBRCAwildtype.ConclusionsPatient demographic and disease characteristics supported the association of a gBRCAm with younger age at initial BC diagnosis and family history of BC and/or ovarian cancer. gBRCAm prevalence in this cohort, not selected on the basis of risk factors for gBRCAm, was slightly higher than previous results suggested. gBRCAm prevalence among patients without a traditional risk factor for harboring a gBRCAm (5.8%) supports current guideline recommendations of routine gBRCAm testing in HER2-negative MBC, as these patients may benefit from poly(ADP-ribose) polymerase (PARP) inhibitor therapy.Trial registrationNCT03078036.
Metabolic syndrome among children and adolescents in low and middle income countries: a systematic review and meta-analysis
Authors: Bitew Zebenay Workneh , Alemu Ayinalem , Ayele Ermias Getaneh , Tenaw Zelalem , Alebel Anmut , Worku Teshager 
Published: October 2020

Abstract
Background
Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is rising in the low and middle income countries (LMICs). There are various studies with inconsistent findings that are inconclusive for policy makers and program planners. Thus, this systematic review and meta-analysis aimed at estimating the pooled prevalence of MetS and its components in LMICs.

Methods
Electronic searches were conducted in international databases including PubMed, Web of Science, EMBASE (Elsevier), Scopus, CINAHL (EBSCOhost), Science direct (Elsevier), Food Science and Technology Abstracts (FSTA), Global Health and Medline, and other sources (World Cat, Google Scholar, and Google). The pooled estimates were computed in the random effect model. The pooled prevalence was computed using the three diagnostic methods (IDF, ATP III and de Ferranti). Publication bias was verified using funnel plot and Egger’s regression test. Subgroup and sensitivity analysis were performed to identify the possible sources of heterogeneity among the included studies.

Result
In this study, 142,142 children and adolescents from 76 eligible articles were included to compute the pooled prevalence of MetS and its components in LMCIs. MeTs among overweight and obese population was computed from 20 articles with the pooled prevalence of 24.09%, 36.5%, and 56.32% in IDF, ATP III and de Ferranti criteria, respectively. Similarly, a total of 56 articles were eligible to compute the pooled prevalence of MetS in the general population of children and adolescents. Hence, Mets was found in 3.98% (IDF), 6.71% (ATP III) and 8.91% (de Ferranti) of study subjects. Regarding the components of MetS, abdominal obesity was the major component in overweight and obese population and low HDL-C was the most common component in the general population. This study also revealed that males were highly affected by MetS than females.

Conclusion
This study illustrates that MetS among children and adolescents is an emerging public health challenge in LMICs, where the prevalence of obesity is on the move. Preventive strategies such as community and school based intervention need to be designed. Promoting physical activities and healthy eating behaviors could avert this problem.
DECIMER: towards deep learning for chemical image recognition
Authors: Rajan Kohulan , Zielesny Achim , Steinbeck Christoph 
Published: October 2020

AbstractThe automatic recognition of chemical structure diagrams from the literature is an indispensable component of workflows to re-discover information about chemicals and to make it available in open-access databases. Here we report preliminary findings in our development of Deep lEarning for Chemical ImagE Recognition (DECIMER), a deep learning method based on existing show-and-tell deep neural networks, which makes very few assumptions about the structure of the underlying problem. It translates a bitmap image of a molecule, as found in publications, into a SMILES. The training state reported here does not yet rival the performance of existing traditional approaches, but we present evidence that our method will reach a comparable detection power with sufficient training time. Training success of DECIMER depends on the input data representation: DeepSMILES are superior over SMILES and we have a preliminary indication that the recently reported SELFIES outperform DeepSMILES. An extrapolation of our results towards larger training data sizes suggests that we might be able to achieve near-accurate prediction with 50 to 100 million training structures. This work is entirely based on open-source software and open data and is available to the general public for any purpose.
Mesenchymal stem cell therapy for liver disease: full of chances and challenges
Authors: Yang Xue , Meng Yan , Han Zhipeng , Ye Fei , Wei Lixin , Zong Chen 
Published: October 2020

AbstractLiver disease is a major health problem that endangers human health worldwide. Currently, whole organ allograft transplantation is the gold standard for the treatment of end-stage liver disease. A shortage of suitable organs, high costs and surgical complications limit the application of liver transplantation. Mesenchymal stem cell therapy has been considered as a promising alternative approach for end-stage liver disease. Some clinical trials have confirmed the effectiveness of MSC therapy for liver disease, but its application has not been promoted and approved. There are still many issues that should be solved prior to using MSC therapy in clinical applications. The types of liver disease that are most suitable for MSC application should be determined, and the preparation and engraftment of MSCs should be standardized. These may be bottlenecks that limit the use of MSCs. We investigated 22 completed and several ongoing clinical trials to discuss these questions from a clinical perspective. We also discussed the important mechanisms by which MSCs play a therapeutic role in liver disease. Finally, we also proposed novel prospective approaches that can improve the therapeutic effect of MSCs.
Design and optimization for UAV-enabled two-way relaying system with SWIPT
Authors: Wang Jinlong , Wang Gang , Chen Guanyi , Li Bo , Zhou Ruofei , Zhang Ruoyu 
Published: October 2020

AbstractIn this paper, we investigate the resource allocation scheme for an unmanned-aerial-vehicle-enable (UAV-enabled) two-way relaying system with simultaneous wireless information and power transfer (SWIPT), where two user equipment exchange information with the help of UAV relay and harvest energy through power splitting (PS) scheme. Under the transmission power constraints at UEs and UAV relay, a non-convex intractable optimization problem is formulated which maximizes the sum retained energy of two UEs while satisfying the minimum signal-to-noise ratio requirement. We decouple the complicated beamforming and PS factor optimization problem into three solvable subproblems and propose an efficient alternating optimization scheme. Subsequently, in order to reduce the complexity, a robust scheme based on generalized singular value decomposition (GSVD) is designed. Finally, numerical results verify the robustness and effectiveness of the two proposed schemes.
Task admission control for application service operators in mobile cloud computing
Authors: Jin Xiaomin , Hua Wenqiang , Wang Zhongmin 
Published: October 2020

AbstractThe resource constraint has become an important factor hindering the further development of mobile devices (MDs). Mobile cloud computing (MCC) is a new approach proposed to extend MDs’ capacity and improve their performance by task offloading. In MCC, MDs send task requests to the application service operator (ASO), which provides application services to MDs and needs to determine whether to accept the task request according to the system condition. This paper studies the task admission control problem for ASOs with the consideration of three features (two-dimensional resources, uncertainty, and incomplete information). A task admission control model, which considers radio resource variations, computing, and radio resources, is established based on the semi-Markov decision process with the goal of maximizing the ASO’s profits while guaranteeing the quality of service (QoS). To develop the admission policy, a reinforcement learning-based policy algorithm, which develops the admission policy through system simulations without knowing the complete system information, is proposed. Experimental results show that the established model adaptively adjusts the admission policy to accept or reject different levels and classes of task requests based on the ASO load, available radio resources, and event type. The proposed policy algorithm outperforms the existing policy algorithms and maximizes the ASO’s profits while guaranteeing the QoS.
Oversummering juvenile and adult Semipalmated sandpipers in Perú gain enough survival to compensate for foregone breeding opportunity
Authors: Tavera Eveling A. , Stauffer Glenn E. , Lank David B. , Ydenberg Ronald C. 
Published: October 2020

AbstractBackgroundAge at maturity and the timing of first breeding are important life history traits. Most small shorebird species mature and breed as ‘yearlings’, but have lower reproductive success than adults. In some species, yearlings may defer northward migration and remain in non-breeding regions (‘oversummering’) until they reach 2 years of age. Some adults also oversummer. Oversummering would be favoured by natural selection if survival were as a result raised sufficiently to compensate for the missed breeding opportunity. Several thousand Semipalmated Sandpipers (Calidris pusilla) spend the non-breeding period at Paracas, Perú, including individuals with long bills (likely from eastern Arctic breeding populations ~ 8000 km distant) and short bills (likely from western Arctic breeding populations, up to 11,000 km distant), with short-billed birds more likely to oversummer. We tested the prediction that oversummering birds have higher survival than migrants, and that the magnitude of this higher survival for oversummering birds is enough to compensate for their lost breeding season.MethodsWe used a Multi-State Mark-Recapture model based on 5 years of encounter data (n = 1963 marked birds, and 3229 resightings) obtained year-round at Paracas, Perú, to estimate seasonal (i.e. breeding and non-breeding) survivorship for migrant and oversummering birds. We calculated the magnitude of the oversummering survival advantage required to compensate, for both yearlings and adults, based on published measures of annual survival and reproductive success. Using bill length as a proxy for migration distance, we investigated whether migratory survival is distance-dependent.ResultsWe estimate that 28% of yearlings and 19% of adults oversummer. Survival is higher for oversummering birds than for migrants, and the oversummering survival advantage is greater for adults (0.215) than for yearlings (0.140). The theoretical thresholds predicted by the size of the missed reproductive opportunity are 0.240 for adults and 0.134 for yearlings. Migratory survival decreases and the oversummering rate increases with migration distance, as assessed by culmen length.ConclusionsOur results support the life history hypothesis that oversummering raises survival enough to compensate for the loss of a breeding opportunity. Greater migration distance lowers survival and increases the probability of oversummering.