bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of core decompression for steroid‐associated osteonecrosis of the femoral head in rabbits
Authors: Maruyama Masahiro , Lin Tzuhua , Kaminow Nicolas I. , Thio Timothy , Storaci Hunter W. , Pan Chi‐Chun , Yao Zhenyu , Takagi Michiaki , Goodman Stuart B. , Yang Yunzhi P. 
Published: October 2020

AbstractAlthough core decompression (CD) is often performed in the early stage of osteonecrosis of the femoral head (ONFH), the procedure does not always prevent subsequent deterioration and the effects of CD are not fully clarified. The aim of this study is to evaluate the efficacy of CD for steroid‐associated ONFH in rabbits. Twelve male and 12 female New Zealand rabbits were injected intramuscularly 20 mg/kg of methylprednisolone once and were divided into the disease control and CD groups. In the disease control group, rabbits had no treatment and were euthanized at 12 weeks postinjection. In the CD group, rabbits underwent left femoral CD at 4 weeks postinjection and were euthanized 8 weeks postoperatively. The left femurs were collected to perform morphological, biomechanical, and histological analysis. Bone mineral density and bone volume fraction in the femoral head in the CD group were significantly higher than in the disease control group. However, no difference in the mechanical strength was observed between the two groups. Histological analysis showed that alkaline phosphatase and CD31 positive cells significantly increased in the males after CD treatment. The number of empty lacunae in the surrounding trabecular bone was significantly higher in the CD group. The current study indicated that CD improved the morphological properties, but did not improve the mechanical strength in the femoral head at early‐stage ONFH. These data suggest the need for additional biological, mechanical strategies, and therapeutic windows to improve the outcome of early‐stage steroid‐associated ONFH.
Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study
Authors: Muaddi Hala , D'Angelica Michael , Wiseman Jason T. , Dillhoff Mary , Latchana Nicholas , Roke Rachel , Ko Yoo‐Joung , Carpizo Darren , Spencer Kristen , Fields Ryan C. , Williams Gregory , Aucejo Federico , Acevedo‐Moreno Lou‐Anne , Billingsley Kevin G. , Walker Brett S. , Mayo Skye C. , Karanicolas Paul J. 
Published: October 2020

AbstractIntroductionHepatic artery infusion pump (HAIP) chemotherapy is a specialized therapy for patients with unresectable colorectal liver metastases (uCRLM). Its effectiveness was demonstrated from a high volume center, with uncertainty regarding the feasibility and safety at other centers. Therefore, we sought to assess the safety and feasibility of HAIP for the management of uCRLM at other centers.MethodsWe conducted a multicenter retrospective cohort study of patients with uCRLM treated with HAIP from January 2003 to December 2017 at six North American centers initiating the HAIP program. Outcomes included the safety and feasibility of HAIP chemotherapy.ResultsWe identified 154 patients with HAIP insertion and the median age of 54 (48–61) years. The burden of disease was >10 intra‐hepatic metastatic foci in 59 (38.3%) patients. Patients received at least one cycle of systemic chemotherapy before HAIP insertion. Major complications occurred in 7 (4.6%) patients during their hospitalization and 13 (8.4%) patients developed biliary sclerosis during follow‐up. A total of 148 patients (96.1%) received at least one‐dose of HAIP chemotherapy with a median of 5 (4–7) cycles. 78 patients (56.5%) had a complete or partial response and 12 (7.8%) received a curative liver resection.ConclusionHAIP programs can be safely and effectively initiated in previously inexperienced centers with good response.
Effect of respiratory muscle training on dysphagia in stroke patients—A retrospective pilot study
Authors: Arnold Robert J. , Bausek Nina 
Published: October 2020

AbstractBackgroundDysphagia is prevalent with cerebrovascular accidents and contributes to the burden of disease and mortality. Strengthening dysfunctional swallow muscles through respiratory muscle training (RMT) has proven effective in improving swallow effectiveness and safety. However, approaches to strengthen only the expiratory muscle groups (EMST) dominate the clinical study literature, with variable outcomes. This study investigated the effect of simultaneous inspiratory‐expiratory muscle strengthening to improve swallowing function in stroke patients.MethodsRecorded data of 20 patients receiving pro bono medical care for dysphagia following stroke were allocated to intervention (IG) or control group (CG) based upon whether they chose combined RMT (cRMT) or not while awaiting swallow therapy services. The intervention group was treated with three 5‐minute sessions of resistive respiratory muscle training for 28 days, while the control group received no RMT or other exercise intervention. Respiratory and swallow outcomes were assessed pre‐ and post‐intervention and included Mann Assessment of Swallowing Ability (MASA), fiberoptic endoscopic evaluation of swallowing (FEES) with penetration‐aspiration scale (PAS), functional oral intake scale (FOIS), patient visual analogue scale (VAS), and peak expiratory flow (PEF).ResultsAfter 28 days, the intervention group demonstrated greater improvements (P value < 0.05) in PEF (IG: 168.03% vs CG: 17.47%), VAS (IG: 103.85% vs CG: 27.54%), MASA (IG: 37.28% vs CG: 6.92%), PAS (IG: 69.84% vs CG: 12.12%), and FOIS (IG: 93.75% vs CG: 21.21%).ConclusioncRMT is a feasible and effective method to improve signs and symptoms of dysphagia while improving airway protection.Level of Evidence3
Effect of compound texture on lubrication and sealing performance of plunger pump
Authors: Jia Hekun , Zhou Zeyuan , Yin Bifeng , Zhou Huiqin , Xu Bo 
Published: October 2020

AbstractA type of compound texture combining micro‐dimple and variable‐depth groove was designed to improve sealing performance and reduce wear of the plunger couple in diesel engine. The simulation results indicate that moderate oil film thickness can be produced by compound texture to settle the lack of lubrication of groove mode. Meanwhile, higher hydrodynamic pressure is produced to improve sealing performance of a plunger couple, tackling the problem of relatively high leakage of micro‐dimple mode. The compound texture was fabricated on the plunger surface by laser surface texturing (LST) and the test results confirmed the improvement of lubrication and sealing performance. The basic tribological test result shows that that the deepest wear depth and average roughness were reduced by 72.4% and 22.6%, respectively. Meanwhile, the engine bench test result shows that the amount of fuel leakage was reduced by 73.1% as well.
A novel two‐dimensional crest factor reduction method based on concurrent output capacity of power amplifiers
Authors: Tang Ke , Huang Hang , Yu Cuiping , Wu Yongle , Jin Qiuyan , Gao Jinchun , Liu Yuanan 
Published: October 2020

AbstractA novel two‐dimensional crest factor reduction (2D‐CFR) is proposed to improve the dual‐band concurrent performance of power amplifiers (PAs). The concurrent performance of target PA can be improved significantly when the power for peak detection conforms to the concurrent characteristic. Peak detection and clipping operation are presented based on concurrent output capacity of PAs, which can be efficiently described by introducing two design parameters. Measured results show that the drain efficiency is improved from 34.2% to 36.6% with the proposed 2D‐CFR when compared with the conventional 2D‐CFR while maintaining similar error vector magnitude and ACPRs, which indicates a significant performance improvement.
Efficient purification of the diarylheptanoid oregonin from red alder (Alnus rubra) leaves and bark combining aqueous extraction, spray drying and flash‐chromatography
Authors: Lea Carmen S. , Simhadri Chakravarthi , Bradbury Stephen G. , Wulff Jeremy E. , Constabel C. Peter 
Published: October 2020

AbstractIntroductionThe diarylheptanoid xyloside oregonin ((5S)‐1,7‐bis(3,4‐dihydroxyphenyl)‐5‐(β‐d‐xylopyranosyloxy)‐heptan‐3‐one) has significant medicinal potential and is found at high concentration in leaves and bark of red alder (Alnus rubra).ObjectivesTo establish inexpensive and easily scaled methods for the extraction and purification of oregonin from timber by‐products.MethodsWe developed a method combining aqueous extraction with spray drying of red alder extract into a powder, thus reducing the need for organic solvents used in traditional Soxhlet extraction or in solvent partitioning. Flash chromatography was utilised to purify oregonin from crude spray‐dried alder extract.ResultsCrude spray‐dried alder extract was comprised of an average of 9% of the diarylheptanoid compound oregonin. Less than 10% thermal degradation of oregonin was observed using extraction temperatures between 25°C and 50°C, followed by spray drying. The structure of purified oregonin was validated using high‐performance liquid chromatography (HPLC), mass spectrometry (MS), ultraviolet spectroscopy (UV), and nuclear magnetic resonance (NMR).ConclusionThe developed method was robust, repeatable, and yielded purified oregonin of greater than > 95% purity (average of 95.8%). Our analysis represents the most complete NMR characterisation of oregonin reported to date.
Design of highly stretchable deep eutectic solvent‐based ionic gel electrolyte with high ionic conductivity by the addition of zwitterion ion dissociators for flexible supercapacitor
Authors: Bu Ximan , Ge Yongxin , Wang Lei , Wu Linlin , Ma Xiaofeng , Lu Duyou 
Published: October 2020

AbstractNonvolatile deep eutectic solvent (DES) electrolytes with good electrochemical stability have recently emerged as promising electrolytes for energy storage devices. In this report, for the first time a polymerized zwitterionic molecule was introduced and a series of hybrid cross‐linked zwitterion‐containing copolymer DES gels are synthesized via UV initiated free‐radical copolymerization of acrylic acid (AA), sulfobetaine vinylimidazole (VIPS) and poly(ethylene glycol) diacrylate (PEGDA) monomers, in situ within DES, which is prepared from 1:2 M ratio of choline chloride and ethylene glycol. Systematically varying the AA:VIPS molar ratio and copolymer contents within the copolymer network enables one to widely tune the mechanical properties and ionic conductivity of the poly(AA‐co‐VIPS) DES gels. The tensile strength of P(AA‐co‐VIPS) DES gels significantly increased from 28 kPa to 176 kPa with fracture strain from 720% to 1370%, while the ionic conductivity of copolymer DES gels remains high from 2.7 to 4.1 mS cm−1 with the increase of copolymer content from 25 wt % to 45 wt%. A copolymer DES gel not only enables a supercapacitor deliver high capacitance of 71.52 F g−1 at 0.5 A g−1, and retains ∼97% of its capacitance after 2000 cycles, but also achieves outstanding capacitive performance over wide temperature range.
Introduction of cell‐selectivity in bovine cathelicidin BMAP‐28 by exchanging heptadic isoleucine with the adjacent proline at a non‐heptadic position
Authors: Azmi Sarfuddin , Verma Neeraj Kumar , Tripathi Jitendra Kumar , Srivastava Saurabh , Verma Devesh Pratap , Ghosh Jimut Kanti 
Published: October 2020

AbstractBovine cathelicidin, BMAP‐28 exhibits potent antimicrobial activity without any cell‐selectivity. Considering the role of its C‐terminus amino acid residues in its cytotoxic activities, we envisioned to rearrange the amino acids at its C‐terminus without altering its composition for designing new cell‐selective BMAP‐28‐analog. Thus an isoleucine residue at 20th position, also an “a” position of its previously identified isoleucine zipper sequence, was exchanged with a proline residue at 19th position. As a result, a remarkable reduction in the hemolytic activity of BMAP‐28 toward human red blood cells (hRBCs) was observed without hampering its antibacterial activity in liquid media, and in presence of salts and serum. BMAP‐28‐analog, BMAP‐28M depolarized S. aureus membrane and bacterial membrane‐mimetic, PE/PG lipid vesicles similar to BMAP‐28 but showed weaker efficacy to depolarize hRBC membrane and mammalian membrane‐mimetic, PC/Chol vesicles. Differences in the localization of tryptophan residues of BMAP‐28 and BMAP‐28M were observed only in PC/Chol vesicles. BMAP‐28 induced pores of ~3.4 nm diameter onto hRBCs whereas BMAP‐28M showed minor perturbation onto these cells. BMAP‐28 and BMAP‐28M induced the entry of calcein (size, ~1 nm) and 4.4 kDa FITC‐dextran (size, ~2.8 nm) into B. megaterium but not of higher sized fluorescent‐dextrans indicating toroidal pore formation onto these bacterial membranes.
Bilateral pulmonary emboli in a teenager with positive SARS‐CoV‐2 antibody
Authors: Kotula John J. , Balakumar Niveditha , Khan Danyal , Patel Bhavi 
Published: October 2020

AbstractThromboembolic phenomena, particularly pulmonary emboli, have been described in adult patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, but have been less evident in children. We describe a case of a teenager with bilateral pulmonary emboli leading to cardiovascular collapse in the setting of a positive SARS‐CoV‐2 IgM antibody.
Physical and social health at the library: Studying small and rural public libraries as venues for group fitness among older adults
Authors: Lenstra Noah , Oguz Fatih 
Published: October 2020

AbstractPublic libraries increasingly offer opportunities to engage in health promotion activities inaccessible elsewhere in the community. Strategies to support physical activity for older adults can be implemented in a variety of different settings, including public libraries. Nonetheless, despite increasing recognition of this role, this trend has received limited scholarly attention. This study reports on a proof of concept study that took place across 12 weeks in 49 small and rural public libraries across the US. During that time, 535 older adults participated in a video‐based exercise program at the library. Participants reported increased levels of physical activity and increased mental health as a result of the availability of this program. These preliminary results demonstrate that public libraries have great potential as partners in efforts to increase healthy lifestyles among Americans, particular older adults, who represent a growing demographic in the U.S. and around the world.
Diffusion and adoption of Linked Data among libraries
Authors: Niu Jinfang 
Published: October 2020

AbstractThrough content analyses of literature about the Linked Data (LD) adoption of individual libraries, this study found that the diffusion of LD among libraries is a decentralized process with high‐degree of reinvention and a continuous process that includes multiple stages and might last for many years. The diffusion of LD among libraries involves the diffusion of numerous related innovations, follows three paths (inter‐library, intra‐library, and inter‐librarian), and is facilitated by four types of institutions (professional associations, vendors, external funders, and leading libraries) and three factors (avoiding re‐inventing the wheel, standardization, and commercialization).
Patient empowerment through mobile health: Case study with a Brazilian application for pregnancy support
Authors: Delgado Gustavo V. , de Carvalho Rodrigo B. , Choo Chun W. , Leite Ramon S. , de Castro José M. 
Published: October 2020

AbstractThis paper analyzes how mobile health applications contribute to the empowerment of health service users. The theoretical foundation includes m‐health, user empowerment, and value co‐creation. Quantitative and qualitative methods were used to investigate the Kangaroo application (Canguru, in Portuguese), which targets Brazilian pregnant women and seeks to make women empowered for a healthy pregnancy. The free app is a healthcare social network designed by a health‐tech startup and a reference Brazilian hospital. It has already supported 350,000 pregnant women, and more than 200 health professionals. The data collection effort comprised application log analysis of 6 months of records of 99,709 users, mobile‐based survey with 429 women and 16 interviews. The results showed that the functionalities of the personal and social dimensions mapped in the application explain 85.5% of the user empowerment. The app social features impacted 2.4 more than the personal functionalities. The quantitative analysis concluded that there was no moderating effect of styles of value co‐creation practices on the relationship between empowerment and its dimensions. The theoretical contribution is associated with the discussion of the influence of personal and social dimensions of m‐health to the user empowerment.
The hitchhiker's guide to scholarly research integrity
Authors: Taswell S. Koby , Triggle Christopher , Vayo June , Dutta Shiladitya , Taswell Carl 
Published: October 2020

AbstractThe pursuit of truth in research should be both an ideal in aspiration and also a reality in practice. The PORTAL‐DOORS Project (PDP) strives to promote creative authenticity, fair citation, and adherence to integrity and ethics in scholarly research publishing using the FAIR family of quantitative metrics with acronym FAIR for the phrases Fair Attribution to Indexed Reports and Fair Acknowledgment of Information Records, and the DREAM principles with acronym DREAM for the phrase Discoverable Data with Reproducible Results for Equivalent Entities with Accessible Attributes and Manageable Metadata. This report presents formalized definitions for idea‐laundering plagiarism by authors, idea‐bleaching censorship by editors, and proposed assertion claims for authors, reviewers, editors, and publishers in ethical peer‐reviewed publishing to support integrity in research. All of these principles have been implemented in version 2 of the PDP‐DREAM ontology written in OWL 2. This PDP‐DREAM ontology will serve as the model foundation for development of a software‐guided workflow process intended to manage the ethical peer‐reviewed publishing of web‐enabled open access journals operated online with PDP software.
Linked data education and training: Past, present, and future
Authors: Dobreski Brian , Zeng Marcia Lei , Kovari Jason , Qin Jian 
Published: October 2020

AbstractStudying, designing, and implementing linked data is becoming an increasingly important part of many information settings. Whether taking part in high‐profile grant funded collaborations, local exploratory projects, or adopting a “wait and see” approach, institutions such as libraries, archives, and enterprise organizations will need professionals versed in linked data technologies and practices. In recent years, many advances have been made toward the establishment of an educational foundation for information professionals in this area, through both the incorporation of linked data topics into formal course curricula as well as the establishment of community‐driven, open access learning resources online. However, questions and challenges remain. In this panel, presenters will explore the past, current, and future states of linked data education and training while addressing ongoing challenges and opportunities for preparing metadata professionals in this area.
A person‐agent and related information resources: A case study of complex relationships
Authors: Lee Hur‐Li , Kipp Margaret , Yang Li 
Published: October 2020

ABSTRACTIdentifying and mapping relationships is of increasing importance as many cultural heritage institutions work to model data in Linked Data (LD) format. As a pilot of a larger LD project, this study examines relationships between information resources, between person‐agents and resources, and between person‐agents, in order to improve description and access to information related to persons and resources. We used a case‐study approach to identify new and previously‐defined relationships in bibliographic records associated with a person‐agent. To find a case that exhibits complex relationships, we selected Lin Huiyin (林徽因), a famous Chinese architect, architectural historian, poet, artist, designer, and writer in the 20th century. We collected 903 records using WorldCat and China Academic Library & Information System. We applied a coding scheme consisting of relationship categories from several existing taxonomies. In the analysis, additional relationships emerged, which were then added to the coding scheme. Our next step is to broaden the scope of the case by examining other types of resources outside libraries such as Lin's architectural works. Further studies of complex cases will allow us to refine our taxonomy and develop an LD model for relationships between resources and person‐agents.
The evolution of LIS research topics and methods from 2006 to 2018: A content analysis
Authors: Ma Jinxuan , Lund Brady 
Published: October 2020

AbstractReplicating a series of studies of LIS research trends performed by Järvelin and colleagues, this content analysis systematically examines the evolution and distribution of LIS research topics and methods at six‐year increments from 2006 to 2018. Bibliographic data was collected for 3,422 articles published in LIS journals for the years of 2006, 2012, and 2018. Using a conceptual research strategy, the researchers identified the central research topics and research method for each article. The findings indicate a shift towards greater emphasis on Scholarly Communications/Informetrics and Information Seeking/Behavior topics, along with a reduction in Information Systems and Library and Information Service topics. Quantitative‐based approaches are predominant across the 3 years examined, with observed growth in the usage of questionnaires and informetric methods from 2006 to 2018. These findings indicate that LIS is a dynamic discipline, with quickly shifting interests/usage of research topics and methods.
Toward epistemic justice: An approach for conceptualizing epistemicide in the information professions
Authors: Patin Beth , Sebastian Melinda , Yeon Jieun , Bertolini Danielle 
Published: October 2020

AbstractThe goal of this exploratory paper is to begin to explicate the concept of epistemicide and articulate its function within the information field. We define epistemicide as the killing, silencing, annihilation, or devaluing of a knowledge system. It is not that we are unaware of the injustices happening within our field, but rather, that we are not in discussion across sub‐fields considering the idea that the collective injustices exist and are problematic on individual and systemic levels. We believe epistemicide happens when several epistemic injustices, such as hermeneutical or testimonial injustices, occur collectively reflecting a structured and systemic oppression of particular ways of knowing. We present epistemicide and epistemic injustice as a concept for understanding and addressing ways knowledge systems are silenced, devalued, or annihilated within library and Information Science (LIS).