bluuebunny/crossref_metadata_2025_split huggingface dataset:
PNO1 promotes cell proliferation in prostate cancer
Authors: Hu Jianpeng , Cui Feilun , Xv Zhipeng , Tan Jian , Wang Zhengyu 
Published: November 2019

Abstract
Background Prostate cancer (PCa) is one of the most commonly diagnosed cancers. The functions of PNO1 in yeasts were involved in regulating ribosome and proteasome biogenesis. However, its roles in PCa remained largely unclear. Methods The present study evaluated the expression levels of PNO1 in PCa by using GSE45016, GSE55945 and GSE17951 datasets. Then, in vivo and in vitro assays were conducted to detect the biological functions of PNO1 in PCa. BALB/c mice were used for in vivo assay in this study. Microarray and bioinformatic analysis were carried out to detect the downstream targets and pathways regulated by PNO1. Results The present study for the first time demonstrated PNO1 was up-regulated in PCa samples compared to normal tissues. ShRNA mediated knockdown of PNO1 significantly suppressed PCa proliferation and clone formation, however, induced PCa apoptosis. Microarray analysis and bioinformatics analysis revealed PNO1 was involved in regulating multiple cancer related biological processes, such as regulation of DNA repair, single organismal cell-cell adhesion, translational initiation, RNA splicing, transcription, and positive regulation of mRNA catabolic process. OF note, in vivo results showed PNO1 knockdown remarkably reduced the PCa growth rate. Conclusions Despite more in-depth research is still required, this study showed PNO1 could serve as a potential biomarker for PCa.
Endoscopic dacryocystorhinostomy to treat congenital nasolacrimal canal dysplasia: A retrospective analysis in 40 children
Authors: Cui Yan-Hui , Zhang Cheng-Yue , Liu Wen , Wu Qian , Yu Gang , Li Li , Wei Wen-Bin 
Published: November 2019

Abstract
Background: To investigate the therapeutic effectiveness and safety of endoscopic dacryocystorhinostomy (EN-DCR) to treat congenital nasolacrimal canal dysplasia (CNCD). Methods: Forty children (50 eyes) with congenital nasolacrimal duct obstruction (CNLDO) and lacrimal bony dysplasia, including 8 children with bony atresia (10 eyes) and 32 with bony stenosis (40 eyes), were recruited in this retrospective study. Standardized EN-DCR was performed in all cases. The postoperative observations included relief of symptoms, fluorescein dye disappearance test (FDDT), syringing of lacrimal passages and anastomotic patency under nasal endoscopy. Patients were followed up for 8-18 months. Results: Standardized EN-DCR surgery had a success (cure and improvement) rate of 100%, including a cure rate of 82% and an improvement rate of 18%. The cure rate among 40 cases of bony nasolacrimal duct stenosis was 82.5%, while that of 10 cases of bony nasolacrimal duct atresia was 80%. Statistical analysis showed that nether the receipt of other treatments before surgery nor the type of bony nasolacrimal duct dysplasia affected the cure rate. No significant complications were observed during postoperative follow-up except for four cases (4 eyes) that suffered middle turbinate and nasal mucosal adhesion and two cases with sinusitis. Conclusions: CNCD is a type of CNLDO that does not respond to conservative and conventional treatment. EN-DCR represents a safe and effective treatment for children with CNCD. In addition, the combination of EN-DCR with lacrimal CT scanning provides advantages over traditional lacrimal surgery in that it has a high success rate with a low incidence of complications. Key words: nasal endoscopy; endoscopic dacryocystorhinostomy (EN-DCR); children; congenital nasolacrimal duct obstruction (CNLDO); nasolacrimal canal dysplasia
Improving the AODV Route Recovery Mechanism Using PSO in WSN
Authors: K.N. Sunil Kumar , Shankar Shiva 
Published: November 2019

Objective:
The conventional Ad Hoc On-Demand Distance Vector (AODV) routing algorithm,
route discovery methods pose route failure resulting in data loss and routing overhead. In
the proposed method, needs significant low energy consumption while routing from one node to
another node by considering the status of node forwards the packet. So that while routing it avoids
unnecessary control overhead and improves the network performance.

Methods:
Particle Swarm Optimization (PSO) algorithm is a nature- inspired, population-based
algorithm. Particle Swarm Optimization (PSO) is a Computational Intelligence technique which
optimizes the objective function. It works by considering that every member of the swarm contributes
in finding the ideal solution by keeping a track of their own best known location and the
best-known location of the group and keeps updating them whenever there is a change and hence
minimizes the objective fitness function. The fitness function which we considered here is the
Node lifetime, Link Lifetime and available Bandwidth. If these parameters are with good then status
of node will be strong and hence routing of packet over those nodes will reduce delay and improves
network performance.

Result:
To verify the feasibility and effectiveness of our proposal, the routing performance of
AODV and PSO-AODV is compared with respect to various network metrics like Network Lifetime,
packet delivery ratio and routing overhead and validated the result by comparing both routing
algorithm using Network Simulator 2. The results of the PSO-AODV has outperformed the
AODV in terms of low energy, less end to end delay and high packet delivery ratio and less control
overhead.

Conclusion:
Here we proposed to use Particle Swarm Optimization in order to obtain the more
suitable parameters for the decision making. The existing AODV protocol was modified to make a
decision to recover from route failure; at the link failure predecessor node implementing PSO
based energy prediction concept and using weights for each argument considered in the decision
function. The fitness values for each weight were found through PSO basic form. We observed
that the PSO showed satisfactory behaviour improvement than the performance of AODV for all
metrics on the investigated scenarios.
ÜNİVERSİTE ÖĞRENCİLERİNDE İNTERNET BAĞIMLILIĞININ DEPRESYON VE ANKSİYETE İLE İLİŞKİSİ
Authors: KORKMAZER Başak , KILINÇARSLAN Mehmet Göktuğ , ŞAHİN Erkan Melih 
Published: November 2019

GİRİŞ Gençlik döneminde riskli sağlık davranışlarına yatkınlık sık görülmektedir ve internet bağımlılığı da bunlardan biridir. İnternet bağımlılığının etiyolojisiyle ilgili araştırmalar henüz başlangıç ​​aşamasındadır ve boyutsal olarak ölçülen depresyon ve sosyal izolasyon göstergeleri ile ilişkilendirilmiştir. Bu araştırmada üniversite öğrencilerinde internet bağımlılığı ile depresyon ve anksiyete arasındaki ilişkiyi incelemeyi amaçladık.YÖNTEM Bu çalışma Çanakkale Onsekiz Mart Üniversitesi’nin 2011 – 2012 eğitim yılında merkez yerleşkesinde eğitim alan 28 572 üniversite öğrencisi üzerinde online anket çalışması olarak yürütüldü. Toplamda 4430 (%15,5) öğrenciye ulaşıldı. Bunların 3064’ü (%69,2) bilgisayar ve internet kullanımı sorularını cevaplamıştı. Çok boyutlu bir çalışmanın parçası olan bu araştırmada 71 soruluk orijinal anket dahilinde internet bağımlılığını ölçmek için BAPİNT ölçeği; depresyon ve anksiyeteyi ölçmek için BAPİ-K ölçeği kullanıldı. Tek değişkenli testlerden sonra Binary Logistic Regression analizi yapıldı.BULGULAR İnternet kullanım sorularına cevap veren katılımcıların ortalama yaşı 21,7±3,2 [17-63] iken %55,1’i (1688) kadın, %44,9’u (1374) erkekti. Katılımcıların %34,6’i BAPINT ölçeğine göre internet bağımlılığına sahipti.Regresyon analizinde tüm yordayıcıları içeren model istatistiki olarak anlamlı bulundu (X2=173,553 p&lt;0,001). Bağımsız değişkenler kontrol edildikten sonra internet bağımlılığını, depresyonun 1,799 (1,485-2,179 p&lt;0,05) kat, anksiyetenin ise 1,708 (1,423-2,050 p&lt;0,05) kat arttırdığı saptandı.TARTIŞMA ve SONUÇ Çalışmamızdaki internet bağımlılığı oranı (%34,6) ülkemizde üniversite öğrencileri arasında yapılmış diğer çalışmaların saptadığı oranlar (%18,9 - %56,9) ile benzerdi. Önceki ulusal ve uluslararası çalışmalarla uyumlu olarak internet bağımlılığının depresyon ve anksiyete gibi ruhsal bozukluklarla ilişki gösterdiği saptandı. İnternet bağımlılığı ile mental sağlık arasındaki nedensellik henüz tam çözümlenememiş olup; her alan ve toplulukta internet kullanımının yaygınlaşmasıyla birlikte özellikle gençler riskli populasyonda yer almakta, anksiyete veya depresyonu mevcut olan gençlerin takibinde internet bağımlılığının da göz önünde bulundurulması önem taşımaktadır.
Effectiveness of arrangement of the long cargo transportation on the fi tting platforms with different length of freight storage
Authors: Mozgrin S. V. , Pisarevskiy G. E. 
Published: November 2019

Fitting platforms of variable freight storage lengths are used for transportation of rails and other cargo up to 25 m long. The use of innovative fixation for transportation on the fitting platforms contributes to enlargement of the range of cargo transported on such rolling stock and establishes conditions for safe transportation of such cargo.To evaluate the effectiveness of the arrangement of long cargo transportation on the fitting platform, this study examines two 25 m long rail transportation options. The transportation option involving two coupled 14.62 m platforms, when the cargo is fixed on the coupled platforms with the standard method is the basic option. The new option involves transportation of the 25 m long rails using 80-feet fitting platforms 25.62 m long at the coupling axes and multiway fi xation sets. A calendar year is assumed as the estimate period. The transported volume is assumed equal for each option, under considering the operating conditions of the calculation unit — one coupling of universal platform (or one 80-feet fitting platform), reducing the financial results to a ton of transported cargo. The value of the annual economic effect for the freight owner (Eyearown) is determined as the change of the freight owner’s expenses due to usage of the new option relative to the basic transportation option.The economic assessment of the transportation is performed considering the interests of each member of the transportation process and tested based on specific data. The results demonstrate the effectiveness of implementation of the technical and technological solution under consideration.
Nordic Gods in Classical Dress
Authors: Vetushko-Kalevich Arsenii 
Published: November 2019

The 19th century in Sweden, like in many other European countries, saw a large decline in the quantity of Neo-Latin literary production. However, a range of skillful Latin poets may be named from this period: Johan Lundblad, Johan Tranér, Emil Söderström, Johan Bergman and others, engaged as well in translating from Swedish into Latin as in composing poems of their own. It was also in the 19th century that the longest Latin poem ever written in Sweden came out – “De diis arctois libri VI” by Carl Georg Brunius (1792–1869), remarkably neglected by the scholars, although it was published twice during the lifetime of its author (1822 and 1857).
The subject of the poem fits perfectly in the intellectual movement of the period, namely national romantic interest in the Nordic antiquities. The six books represent a summary of Eddaic mythology from the creation of the Universe until the Ragnarök.
Brunius’ admiration for the Scandinavian Middle Ages is apparent; later it turned out to be productive in architecture, the field in which Brunius is most remembered nowadays. Brunius does not seek to turn Scandinavian gods into Greek ones. He accurately follows his sources (both the prosaic and, to a somewhat smaller extent, the poetic Edda) in content, sometimes even in wording. However, it should be born in mind that the writer was a classicist by his education. Although many compositional traits of ancient epos are lacking in the poem, it is full of the allusions to classical authors at the phrasal level. Some of them are formulaic verse elements, others deliberate and exquisite quotations. It is this elegant combination of close adherence to the sources with the use of the ancient authors (Virgil, Lucretius, Ovid, Horace) that the paper is mainly focused on.
Artificial Intelligence Technologies for Coping with Alarm Fatigue in Hospital Environments Because of Sensory Overload: Algorithm Development and Validation
Authors: Fernandes Chrystinne Oliveira , Miles Simon , Lucena Carlos José Pereira De , Cowan Donald 
Published: November 2019

Background
Informed estimates claim that 80% to 99% of alarms set off in hospital units are false or clinically insignificant, representing a cacophony of sounds that do not present a real danger to patients. These false alarms can lead to an alert overload that causes a health care provider to miss important events that could be harmful or even life-threatening. As health care units become more dependent on monitoring devices for patient care purposes, the alarm fatigue issue has to be addressed as a major concern for the health care team as well as to enhance patient safety.

Objective
The main goal of this paper was to propose a feasible solution for the alarm fatigue problem by using an automatic reasoning mechanism to decide how to notify members of the health care team. The aim was to reduce the number of notifications sent by determining whether or not to group a set of alarms that occur over a short period of time to deliver them together, without compromising patient safety.

Methods
This paper describes: (1) a model for supporting reasoning algorithms that decide how to notify caregivers to avoid alarm fatigue; (2) an architecture for health systems that support patient monitoring and notification capabilities; and (3) a reasoning algorithm that specifies how to notify caregivers by deciding whether to aggregate a group of alarms to avoid alarm fatigue.

Results
Experiments were used to demonstrate that providing a reasoning system can reduce the notifications received by the caregivers by up to 99.3% (582/586) of the total alarms generated. Our experiments were evaluated through the use of a dataset comprising patient monitoring data and vital signs recorded during 32 surgical cases where patients underwent anesthesia at the Royal Adelaide Hospital. We present the results of our algorithm by using graphs we generated using the R language, where we show whether the algorithm decided to deliver an alarm immediately or after a delay.

Conclusions
The experimental results strongly suggest that this reasoning algorithm is a useful strategy for avoiding alarm fatigue. Although we evaluated our algorithm in an experimental environment, we tried to reproduce the context of a clinical environment by using real-world patient data. Our future work is to reproduce the evaluation study based on more realistic clinical conditions by increasing the number of patients, monitoring parameters, and types of alarm.
Effect of Various Invitation Schemes on the Use of Fecal Immunochemical Tests for Colorectal Cancer Screening: Protocol for a Randomized Controlled Trial
Authors: Gruner Laura Fiona , Hoffmeister Michael , Ludwig Leopold , Brenner Hermann 
Published: November 2019

Background
Fecal occult blood testing has been offered for many years in the German health care system, but participation rates have been notoriously low.

Objective
The aim of this study is to evaluate the effect of various personal invitation schemes on the use of fecal immunochemical tests (FITs) in persons aged 50-54 years.

Methods
This study consists of a three-armed randomized controlled trial: (1) arm A: an invitation letter from a health insurance plan including a FIT test kit, (2) arm B: an invitation letter from a health insurance plan including an offer to receive a free FIT test kit by mail upon easy-to-handle request (ie, by internet, fax, or reply mail), and (3) arm C: an information letter on an existing colonoscopy offer (ie, control). Within arms A and B, a random selection of 50% of the study population will receive reminder letters, the effects of which are to be evaluated in a substudy.

Results
A total of 17,532 persons aged 50-54 years in a statutory health insurance plan in the southwest of Germany—AOK Baden-Wuerttemberg—were sent an initial invitation, and 5825 reminder letters were sent out. The primary end point is FIT usage within 1 year from receipt of invitation or information letter. The main secondary end points include gender-specific FIT usage within 1 year, rates of positive test results, rates of colonoscopies following a positive test result, and detection rates of advanced neoplasms. The study was launched in September 2017. Data collection and workup were completed in fall 2019.

Conclusions
This randomized controlled trial will provide important empirical evidence for enhancing colorectal cancer screening offers in the German health care system.

Trial Registration
German Clinical Trials Register (DRKS) DRKS00011858; https://bit.ly/2UBTIdt

International Registered Report Identifier (IRRID)
DERR1-10.2196/16413
Modelo de Cascada de Atención para la co-infección de las hepatitis virales para el cuidado continuo en personas con VIH/Sida
Authors: Tapia Leandro , Peña Paola , Manoslavas Laura , Paulino-Ramírez Robert 
Published: November 2019

Introducción: las coinfecciones con hepatitis virales y el VIH representan un riesgo por su alta transmisibilidad y complicaciones. Es de vital importancia que se puedan identificar las barreras de acceso y manejo de las coinfeccio-nes del VIH y la Hepatitis B y C. El propósito del estudio es describir la cascada de atención para la coinfección de las hepatitis virales en personas viviendo con VIH/SIDA.
Métodos: se delimitaron los indicadores de manejo y seguimiento de los pacientes monitoreados actualmente en clínicas de primer nivel de atención en Santo Domingo y Santiago. Los datos recopilados fueron analizados a partir de los registros escritos de los pacientes en seguimiento, para evaluar los datos epidemiológicos y serológicos que se obtuvieron de los archivos clínicos.
Resultados: se demostró que un 100 % de los pacientes fueron enrolados, 85.7 % se consideraron como retenidos en el manejo de la coinfección VIH/VHB y solamente 71.4 % recibieron TARV basado en Tenofovir. La casca-da de atención para la coinfección VIH/VHC muestra un vínculo de 87.5 % de los pacientes, 75 % fueron retenidos y ninguno recibió tratamiento.
Conclusión: la identificación de los factores de riesgo que influyen en las brechas de la cascada es fundamental para optimizar el manejo y monitoreo de los pacientes coinfec-tados, teniendo en cuenta que es preciso poder reconocer aquellos infectados para iniciar tratamiento de inmediato y así prever secuelas citopatológicas hepáticas.
Anomalía de Poland, a propósito de dos casos
Authors: Almánzar Rosario 
Published: November 2019

Introducción: el síndrome de Poland, conocido también como secuencia de Poland o anomalía de Poland, fue descrito por primera vez por Alfred Poland en 1841. Corresponde a una alteración musculoesquelética congénita, caracterizada por la ausencia total o parcial del músculo pectoral mayor, asociada a anormalidades de la extremidad superior ipsilateral.
Objetivo: se presentan dos casos de niñas que consultaron por asimetría mamaria, en el primer caso una niña de 12 años con ausencia del pectoral mayor y antecedente de postquirúrgicos sindactilia de mano derecha ipsilateral. El segundo caso, una niña de 9 años con asimetría mamaria sin alteración en la extremidad.
Conclusión: la anomalía de Poland o secuencia de Poland es una alteración musculoesquelética de presentación infrecuente, de aparición esporádica, de mayor prevalencia en masculinos, afecta generalmente el lado derecho del cuerpo, muy pocas veces amerita tratamiento quirúrgico.
Geometric analysis of alveolar bone around the incisors after anterior retraction following premolar extraction
Authors: Zhang Fan , Lee Suk-Cheol , Lee Jun-Beom , Lee Kyung-Min 
Published: November 2019

ABSTRACT

Objective:
To evaluate changes in shape and alterations in thickness and vertical marginal bone levels of the alveolar bone around the maxillary and mandibular incisors before and after orthodontic treatment with premolar extraction using geometric morphometric analysis.

Materials and Methods:
Thirty-six patients with Class I bialveolar protrusion who underwent orthodontic treatment with premolar extraction were included. Cone-beam computed tomographic scans were obtained from the patients before and after treatment. Five fixed landmarks and 70 semilandmarks were used to represent the morphology of the alveolar bone around the maxillary and mandibular incisors. The coordinates of the landmarks of the alveolar bones were generated by Procrustes fit. The labial and lingual alveolar bone thicknesses around the maxillary and mandibular incisors and vertical marginal bone level were assessed quantitatively.

Results:
There was a significant difference in shape change of the alveolar bone before and after treatment. The deformation grid of the thin plate spline showed that the thickness and vertical marginal bone decreased on the lingual side after treatment. Shape changes were greater for the lingual alveolar bone on the mandibular incisor than for the maxillary incisors.

Conclusions:
Orthodontic treatment with premolar extraction might cause loss of alveolar bone around the maxillary and mandibular incisors. Careful consideration is needed to avoid iatrogenic degeneration of periodontal support around the incisors, particularly in the lingual area.
Pengaruh Karakteristik Perusahaan, Karakteristik Obligasi, Reputasi Auditor Terhadap Peringkat Obligasi
Authors: Wijaya Rovinson 
Published: November 2019

This study aims to examine the factors affecting the rating of obligations provided by PEFINDO on public companies listed on the Indonesia Stock Exchange with observation period 2012-2016. Independent variables in this study are company characteristics consisting of retained earnings and profitability, obligation characteristics consisting of obligation guarantee and obligation maturity, and auditor reputation. The sample was taken by using purposive technique and obtained 203 public companies listed in Indonesia Stock Exchange. Regression results show that the retained earnings, profitability, and reputation of the auditor are positively influenced by the obligation rating, while the obligation guarantee and obligation maturity have no effect on the bond rating.

Abstrak
Penelitian ini bertujuan untuk menguji faktor-faktor yang mempengaruhi peringkat obligasi yang diberikan PEFINDO pada perusahaan publik yang terdaftar pada Bursa Efek Indonesia dengan periode pengamatan 2012 – 2016. Variabel independen dalam penelitian ini berupa karakteristik perusahaan yang terdiri dari laba ditahan dan profitabilitas, karakteristik obligasi yang terdiri dari jaminan obligasi dan umur obligasi, serta reputasi auditor. Sampel diambil dengan menggunakan tehnik purposive dan didapat 203 perusahaan publik yang terdaftar di Bursa Efek Indonesia. Hasil regresi menunjukkan bahwa besar laba ditahan, profitabilitas, dan reputasi auditor bepengaruh positif terhadap peringkat obligasi, sedangkan jaminan obligasi dan umur obligasi tidak berpengaruh terhadap peringkat obligasi.
Un maestro renovador: David Bayón Carretero (1895-1981)
Authors: Ortiz de Santos Rosa , Berzal de la Rosa Enrique , Torrego Egido Luis 
Published: November 2019

En las dos décadas previas a la Guerra Civil, un amplio sector del magisterio español, los denominados maestros renovadores, impulsan desde la escuela una extraordinaria renovación que no es sólo educativa, sino también social. Este trabajo se aproxima a la figura de David Bayón Carretero, uno de esos maestros renovadores, muy preocupado por la escuela rural y por la formación del magisterio, cuya labor puede inscribirse en los esfuerzos de ese colectivo por la mejora de la educación y la modernización de la escuela. Como el resto del sector, fue sometido a una depuración meticulosa e inquisitorial.