bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Feedback Valence Differentially Modulates the Reward Positivity, P300, and Late Positive Potential
Authors: Funkhouser Carter J. , Auerbach Randy P. , Kujawa Autumn , Morelli Sylvia A. , Phan K. Luan , Shankman Stewart A. 
Published: October 2019

Abstract. Abnormal social or reward processing is associated with several mental disorders. Although most studies examining reward processing have focused on monetary rewards, recent research also has tested neural reactivity to social rewards (e.g., positive social feedback). However, the majority of these studies only include two feedback valences (e.g., acceptance, rejection). Yet, social evaluation is rarely binary (positive vs. negative) and people often give “on the fence” or neutral evaluations of others. Processing of this type of social feedback may be ambiguous and impacted by factors such as psychopathology, self-esteem, and prior experiences of rejection. Thus, the present study probed the reward positivity (RewP), P300, and late positive potential (LPP) following acceptance, rejection, and “on the fence” [between acceptance and rejection] feedback in undergraduate students ( n = 45). Results indicated that the RewP showed more positive amplitudes following acceptance compared to both rejection and “on the fence” feedback, and the RewP was larger (i.e., more positive) following rejection relative to “on the fence” feedback. In contrast, the P300 did not differ between rejection and “on the fence” feedback, and both were reduced compared to acceptance. The LPP was blunted in response to rejection relative to acceptance and “on the fence” feedback (which did not differ from each other). Exploratory analyses demonstrated that greater self-reported rejection sensitivity was associated with a reduced LPP to acceptance. Taken together, these findings suggest that the neural systems underlying the RewP, P300, and LPP may evaluate “on the fence” social feedback differently, and that individuals high on rejection sensitivity may exhibit reduced attention toward and elaborative processing of social acceptance.
Intercomparison of Snow Melt Onset Date Estimates From Optical and Microwave Satellite Instruments Over the Northern Hemisphere for the Period 1982–2015
Authors: Kouki K. , Anttila K. , Manninen T. , Luojus K. , Wang L. , Riihelä A. 
Published: October 2019

AbstractRobust melt season timing and length estimates are important for hydrological and climatological applications; due to the large area and sparse in situ measurements, snow melt monitoring at the continental scale is only possible from satellites. We intercompared melt onset date (MOD) estimates obtained from optical and microwave satellite sensors over the Northern Hemisphere between 1982 and 2015 and subsequently analyzed the causes of the similarities and dissimilarities found. The optical satellite data are based on the mean surface albedo from the Satellite Application Facility for Climate Monitoring (CM SAF) CLouds, Albedo and RAdiation second release Surface ALbedo (CLARA‐A2 SAL) data set. The microwave satellite data are based on temporal variations in the differences of the brightness temperature from satellite passive microwave radiometers. The analysis shows that the microwave‐based method detects melt onset on average 10 days later than the albedo‐based method, which results from the different melt detection methods; the albedo‐based method observes the point when the spring snow metamorphism begins to have a detectable effect on snow albedo, whereas the microwave‐based method detects the appearance of meltwater in snowpack. The difference in MOD decreases in forests, because canopy protects snow from sunlight delaying snow metamorphism. Additionally, we analyzed the MOD estimates for trends across the Northern Hemisphere and separately for Eurasia and North America. A statistically significant negative trend toward earlier melt onset exists in all cases, which is consistent with previous studies.
Dust and Snow Cover on Saturn's Icy Moons
Authors: Le Gall A. , West R. D. , Bonnefoy L. E. 
Published: October 2019

AbstractThe final analysis of the Cassini radar observations of Saturn's icy moons presented here shows that the exchange of material between the planet's dust rings and moons, which is specific to the Saturnian system, plays a key role in the current state of the airless satellite regolith. Far from Saturn, the vast debris ring from Phoebe progressively coats the leading side of Iapetus with optically dark material reducing its radar brightness. On the contrary, close to the planet, the extreme radar brightness of the innermost moons Mimas, Enceladus, and Tethys (that exceeds that of the Galilean satellites) is most likely related to Enceladus's geysers and the E‐ring which brings ultraclean water ice to their surfaces. The measured radar albedos and observed hemispheric dichotomies require at least a few decimeters thick “snow” cover and that the near surfaces of Saturn's innermost moons contain especially efficient backscattering structures whose nature remains an outstanding problem.
Control of Volcanic Activity by Crustal Structure: Inference from the Izu‐Bonin‐Mariana and Northeast Japan Arcs
Authors: Kaneko Katsuya , Mishiro Kenta , Tatsumi Yoshiyuki 
Published: October 2019

AbstractVolcanic activities in the Izu‐Bonin‐Mariana (IBM) oceanic arc and the Northeast Japan (NEJ) continental arc are different in spite of rather constant subduction rates of the same Pacific plate. IBM volcanoes are much more voluminous than NEJ volcanoes; IBM magmas are predominantly basaltic whereas NEJ magmas are andesitic. We propose that the crustal density structures play a key role in those differences. The crustal density structures were estimated based on seismic P‐wave velocity structure and thermodynamic calculation, suggesting that the neutral buoyancy level of a primitive, mantle‐derived basalt, where a magma chamber forms, is shallower in the IBM arc than the NEJ arc. If a magma that differentiates and attains water oversaturation could erupt at the surface, a larger amount of crystallization should occur for the magma in a deeper chamber. This idea explains that erupting magma in the IBM arc is more voluminous and more mafic than those in the NEJ magma.
Picoplankton Carbon Biomass Assessments and Distribution of Prochlorococcus Ecotypes Linked to Loop Current Eddies During Summer in the Southern Gulf of Mexico
Authors: Linacre L. , Durazo R. , Camacho‐Ibar V. F. , Selph K. E. , Lara‐Lara J. R. , Mirabal‐Gómez U. , Bazán‐Guzmán C. , Lago‐Lestón A. , Fernández‐Martín E. M. , Sidón‐Ceseña K. 
Published: October 2019

AbstractAssessments of picoplankton carbon biomass in the pelagic ecosystem over the deep region of the southern Gulf of Mexico were conducted during three consecutive summer cruises. Notably, the relationship between carbon distribution of Prochlorococcus (PRO) and Loop Current (LC) dynamics was evaluated. Seawater samples were collected from the euphotic zone (~150 m) for estimating the abundance of the picoplankton populations using flow cytometry analyses. Carbon biomass estimates were based on cell abundance and variable conversion factors computed across stations and depths. On average, about half of the total depth‐integrated carbon biomass of picoplankton was attributed to heterotrophic bacteria (HB, 54%) and three autotrophic populations (Prochlorococcus, Synechococcus, and pico‐eukaryotes, 46%). In agreement with previous winter assessments, PRO was the dominant component of abundance (~90%) and pico‐phytoplankton community biomass (>70%). Based on molecular analyses, distinct ecotypes of high‐light PRO and low‐light (LL) PRO were found within the euphotic zone, vertically distributed along light and nutrient gradients. Also, PRO distributions were related to hydrographic conditions strongly modulated by mesoscale dynamics. LL‐PRO subgroups, located close to the nutricline under LL conditions, were associated with the westward propagation of anticyclonic eddies that episodically detach from the LC. This study highlights the role of the LC and its eddies in the transport and distribution of carbon biomass into the Gulf of Mexico, as represented by the deep subgroups of the dominant, tiniest autotroph within this oligotrophic ecosystem.
East Asian Study of Tropospheric Aerosols and their Impact on Regional Clouds, Precipitation, and Climate (EAST‐AIRCPC)
Authors: Li Zhanqing , Wang Yuan , Guo Jianping , Zhao Chuanfeng , Cribb Maureen C. , Dong Xiquan , Fan Jiwen , Gong Daoyi , Huang Jianping , Jiang Mengjiao , Jiang Yiquan , Lee S.‐S. , Li Huan , Li Jiming , Liu Jianjun , Qian Yun , Rosenfeld Daniel , Shan Siyu , Sun Yele , Wang Huijun , Xin Jinyuan , Yan Xin , Yang Xin , Yang Xiu‐qun , Zhang Fang , Zheng Youtong 
Published: October 2019

AbstractAerosols have significant and complex impacts on regional climate in East Asia. Cloud‐aerosol‐precipitation interactions (CAPI) remain most challenging in climate studies. The quantitative understanding of CAPI requires good knowledge of aerosols, ranging from their formation, composition, transport, and their radiative, hygroscopic, and microphysical properties. A comprehensive review is presented here centered on the CAPI based chiefly, but not limited to, publications in the special section named EAST‐AIRcpc concerning (1) observations of aerosol loading and properties, (2) relationships between aerosols and meteorological variables affecting CAPI, (3) mechanisms behind CAPI, and (4) quantification of CAPI and their impact on climate. Heavy aerosol loading in East Asia has significant radiative effects by reducing surface radiation, increasing the air temperature, and lowering the boundary layer height. A key factor is aerosol absorption, which is particularly strong in central China. This absorption can have a wide range of impacts such as creating an imbalance of aerosol radiative forcing at the top and bottom of the atmosphere, leading to inconsistent retrievals of cloud variables from space‐borne and ground‐based instruments. Aerosol radiative forcing can delay or suppress the initiation and development of convective clouds whose microphysics can be further altered by the microphysical effect of aerosols. For the same cloud thickness, the likelihood of precipitation is influenced by aerosols: suppressing light rain and enhancing heavy rain, delaying but intensifying thunderstorms, and reducing the onset of isolated showers in most parts of China. Rainfall has become more inhomogeneous and more extreme in the heavily polluted urban regions.
The Impact of Prescribed Ozone in Climate Projections Run With HadGEM3‐GC3.1
Authors: Hardiman Steven C. , Andrews Martin B. , Andrews Timothy , Bushell Andrew C. , Dunstone Nick J. , Dyson Harold , Jones Gareth S. , Knight Jeff R. , Neininger Erica , O'Connor Fiona M. , Ridley Jeff K. , Ringer Mark A. , Scaife Adam A. , Senior Catherine A. , Wood Richard A. 
Published: October 2019

AbstractThe Coupled Model Intercomparison Project 6 protocol suggests prescribing preindustrial ozone concentrations in abrupt‐4xCO2 simulations. This leads to a mismatch between the thermal tropopause, which rises due to climate change, and the ozone tropopause, which remains fixed. The result is unphysically high ozone concentrations in the upper troposphere, leading to a warm bias in cold point temperature and increased stratospheric water vapor. In the U.K. physical climate model HadGEM3‐GC3.1 this increases the surface climate sensitivity. In the future, other climate models without interactive ozone schemes may face similar problems. We describe a method to interactively redistribute ozone in climate simulations, which removes the inconsistency between the thermal and ozone tropopause heights while retaining the prescribed ozone distribution as closely as possible. This removes unphysical consequences of the tropopause mismatch, while still allowing a fair comparison against other Coupled Model Intercomparison Project 6 model simulations. After each model year, the monthly mean, zonal mean, thermal tropopause is formed based on the previous two model years. The ozone tropopause is defined at 1 km below the thermal tropopause by setting ozone concentrations there to 80 ppbv, and smoothing appropriately. The mass of ozone removed from the troposphere is added to the stratosphere thus conserving the total mass of ozone. This redistribution is then applied proportionally to the 3‐D monthly mean ozone concentrations. The climate model is run for the following year, using this redistributed ozone, and then the whole process is repeated. Results are presented from preindustrial and abrupt‐4xCO2 simulations, but this method can be used for any climate simulation.
Revisiting the Hewlett and Hibbert (1963) Hillslope Drainage Experiment and Modeling Effects of Decadal Pedogenic Processes and Leaky Soil Boundary Conditions
Authors: Lee Raymond M. , McGuire Kevin J. , Strahm Brian D. , Knoepp Jennifer D. , Jackson C. Rhett , Stewart Ryan D. 
Published: October 2019

AbstractSubsurface flow dominates water movement from hillslopes to streams in most forested headwater catchments. Hewlett and Hibbert (1963,https://doi.org/10.1029/JZ068i004p01081) constructed an idealized hillslope model (0.91 × 0.91 × 15.0 m; 21.8°) using reconstituted C horizon soil to investigate importance of interflow, a type of subsurface flow. They saturated the model, covered it to prevent evaporation, and allowed free drainage for 145 days. The resulting recession drainage curve suggested two phases: fast drainage of saturated soil in the first 1.5 days and then slow drainage of unsaturated soil. Hydrologists interpreted the latter as evidence interflow could sustain baseflow, even during extended drought. Since that experiment, typical forest vegetation grew in the model, providing root and litter inputs for 55 years. We removed all aboveground live biomass and repeated the experiment physically and numerically (HYDRUS‐2D), hypothesizing that pedogenesis would change the drainage curve and further elucidate the role of unsaturated flow from hillslopes. Contrary to this hypothesis, drainage curves in our twice‐repeated physical experiments and numerical simulation were unchanged for the first ~10 days, indicating pedogenesis and biological processes had not largely altered bulk hydraulic conductivities or soil moisture release characteristics. However, drainage unexpectedly ceased after about 2 weeks (14.3 ± 2.5 days), an order of magnitude sooner than in the original experiment, due to an apparent leak in the hillslope analogous to commonly observed bedrock fractures in natural systems. Thus, our results are a more natural recession behavior that highlight how incorporation of alternative hydrologic outputs can reduce drainage duration and volume from soils to baseflow.
A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90
Authors: Yu Chen-Yang , Han Ji-Xuan , Zhang Junfang , Jiang Penglei , Shen Chaoqin , Guo Fangfang , Tang Jiayin , Yan Tingting , Tian Xianglong , Zhu Xiaoqiang , Ma Dan , Hu Ye , Xie Yuanhong , Du Wan , Zhong Ming , Chen Jinxian , Liu Qiang , Sun Danfeng , Chen Yingxuan , Zou Weiping , Hong Jie , Chen Haoyan , Fang Jing-Yuan 
Published: October 2019

Abstract
Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SNP in the second intron of the CDH1, as the putative causal variant. In addition, we found an association of CRC-risk allele C of rs7198799 with elevated transcript level of biological plausible candidate gene ZFP90 via expression quantitative trait loci analysis. Mechanistically, causal variant rs7198799 resides in an enhancer element and remotely regulate ZFP90 expression by targeting the transcription factor NFATC2. Remarkably, CRISPR/Cas9-guided single-nucleotide editing demonstrated the direct effect of rs7198799 on ZFP90 expression and CRC cellular malignant phenotype. Furthermore, ZFP90 affects several oncogenic pathways, including BMP4, and promotes carcinogenesis in patients and in animal models with ZFP90 specific genetic manipulation. Taken together, these findings reveal a risk SNP-mediated long-range regulation on the NFATC2-ZFP90-BMP4 pathway underlying the initiation of CRC.
Multiple associative structures created by reinforcement and incidental statistical learning mechanisms
Authors: Klein-Flügge Miriam C. , Wittmann Marco K. , Shpektor Anna , Jensen Daria E. A. , Rushworth Matthew F. S. 
Published: October 2019

AbstractLearning the structure of the world can be driven by reinforcement but also occurs incidentally through experience. Reinforcement learning theory has provided insight into how prediction errors drive updates in beliefs but less attention has been paid to the knowledge resulting from such learning. Here we contrast associative structures formed through reinforcement and experience of task statistics. BOLD neuroimaging in human volunteers demonstrates rigid representations of rewarded sequences in temporal pole and posterior orbito-frontal cortex, which are constructed backwards from reward. By contrast, medial prefrontal cortex and a hippocampal-amygdala border region carry reward-related knowledge but also flexible statistical knowledge of the currently relevant task model. Intriguingly, ventral striatum encodes prediction error responses but not the full RL- or statistically derived task knowledge. In summary, representations of task knowledge are derived via multiple learning processes operating at different time scales that are associated with partially overlapping and partially specialized anatomical regions.
Interval breast cancer is associated with other types of tumors
Authors: Grassmann Felix , He Wei , Eriksson Mikael , Gabrielson Marike , Hall Per , Czene Kamila 
Published: October 2019

AbstractBreast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC of which 1,772 are interval and 13,074 screen-detected. Compared to women with screen-detected cancers, interval breast cancer patients are more likely to have a non-BC tumor before (Odds ratio (OR): 1.43 [1.19–1.70], P = 9.4 x 10−5) and after (OR: 1.28 [1.14–1.44], P = 4.70 x 10−5) breast cancer diagnosis, are more likely to report a family history of non-BC tumors and have a lower genetic risk score based on common variants for non-BC tumors. In conclusion, interval breast cancer is associated with other tumors and common cancer variants are unlikely to be responsible for this association. These findings could have implications for future screening and prevention programs.
A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila
Authors: Babski H. , Jovanic T. , Surel C. , Yoshikawa S. , Zwart M. F , Valmier J. , Thomas J. B. , Enriquez J. , Carroll P. , Garcès A. 
Published: October 2019

AbstractInterneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+ neurons are highly diverse and selective activation of these different subtypes disrupts larval body posture and induces specific locomotor behaviors. Finally, we show that a small subset of TJ+ GABAergic INs, singled out by the expression of a unique transcription factors code, controls larval crawling speed.
Revealing ferroelectric switching character using deep recurrent neural networks
Authors: Agar Joshua C. , Naul Brett , Pandya Shishir , van der Walt Stefan , Maher Joshua , Ren Yao , Chen Long-Qing , Kalinin Sergei V. , Vasudevan Rama K. , Cao Ye , Bloom Joshua S. , Martin Lane W. 
Published: October 2019

AbstractThe ability to manipulate domains underpins function in applications of ferroelectrics. While there have been demonstrations of controlled nanoscale manipulation of domain structures to drive emergent properties, such approaches lack an internal feedback loop required for automatic manipulation. Here, using a deep sequence-to-sequence autoencoder we automate the extraction of latent features of nanoscale ferroelectric switching from piezoresponse force spectroscopy of tensile-strained PbZr0.2Ti0.8O3 with a hierarchical domain structure. We identify characteristic behavior in the piezoresponse and cantilever resonance hysteresis loops, which allows for the classification and quantification of nanoscale-switching mechanisms. Specifically, we identify elastic hardening events which are associated with the nucleation and growth of charged domain walls. This work demonstrates the efficacy of unsupervised neural networks in learning features of a material’s physical response from nanoscale multichannel hyperspectral imagery and provides new capabilities in leveraging in operando spectroscopies that could enable the automated manipulation of nanoscale structures in materials.
Tetraploidy causes chromosomal instability in acentriolar mouse embryos
Authors: Paim Lia Mara Gomes , FitzHarris Greg 
Published: October 2019

AbstractTetraploidisation is considered a common event in the evolution of chromosomal instability (CIN) in cancer cells. The current model for how tetraploidy drives CIN in mammalian cells is that a doubling of the number of centrioles that accompany the genome doubling event leads to multipolar spindle formation and chromosome segregation errors. By exploiting the unusual scenario of mouse blastomeres, which lack centrioles until the ~64-cell stage, we show that tetraploidy can drive CIN by an entirely distinct mechanism. Tetraploid blastomeres assemble bipolar spindles dictated by microtubule organising centres, and multipolar spindles are rare. Rather, kinetochore-microtubule turnover is altered, leading to microtubule attachment defects and anaphase chromosome segregation errors. The resulting blastomeres become chromosomally unstable and exhibit a dramatic increase in whole chromosome aneuploidies. Our results thus reveal an unexpected mechanism by which tetraploidy drives CIN, in which the acquisition of chromosomally-unstable microtubule dynamics contributes to chromosome segregation errors following tetraploidisation.
Expansion of phycobilisome linker gene families in mesophilic red algae
Authors: Lee JunMo , Kim Dongseok , Bhattacharya Debashish , Yoon Hwan Su 
Published: October 2019

AbstractThe common ancestor of red algae (Rhodophyta) has undergone massive genome reduction, whereby 25% of the gene inventory has been lost, followed by its split into the species-poor extremophilic Cyanidiophytina and the broadly distributed mesophilic red algae. Success of the mesophile radiation is surprising given their highly reduced gene inventory. To address this latter issue, we combine an improved genome assembly from the unicellular red alga Porphyridium purpureum with a diverse collection of other algal genomes to reconstruct ancient endosymbiotic gene transfers (EGTs) and gene duplications. We find EGTs associated with the core photosynthetic machinery that may have played important roles in plastid establishment. More significant are the extensive duplications and diversification of nuclear gene families encoding phycobilisome linker proteins that stabilize light-harvesting functions. We speculate that the origin of these complex families in mesophilic red algae may have contributed to their adaptation to a diversity of light environments.