bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chancen von künstlicher Intelligenz und Big Data für die Diagnostik und Behandlung der altersabhängigen Makuladegeneration
Authors: Treder Maximilian , Eter Nicole 
Published: October 2019

ZusammenfassungDie altersabhängige Makuladegeneration (AMD) ist der führende Grund für Erblindung in der westlichen Welt. Für die neovaskuläre Verlaufsform steht mit der intravitrealen Anti-VEGF-Injektion (VEGF: vascular endothelial growth factor) eine wirksame Therapie zur Verfügung. In den letzten Jahren haben die multimodale Bildgebung und die standardisierte elektronische Patientendokumentation geholfen, die Diagnostik und das Management der AMD-Patienten zu verbessern. Mit dem Aufkommen der künstlichen Intelligenz und Big Data ergeben sich in diesem Zusammenhang viele Chancen für die Zukunft. Dieser Artikel soll einen Überblick über mögliche Anwendungen geben.
Towards a Maturity Model for Clinical Decision Support Operations
Authors: Orenstein Evan W. , Muthu Naveen , Weitkamp Asli O. , Ferro Daria F. , Zeidlhack Mike D. , Slagle Jason , Shelov Eric , Tobias Marc C. 
Published: October 2019

AbstractClinical decision support (CDS) systems delivered through the electronic health record are an important element of quality and safety initiatives within a health care system. However, managing a large CDS knowledge base can be an overwhelming task for informatics teams. Additionally, it can be difficult for these informatics teams to communicate their goals with external operational stakeholders and define concrete steps for improvement. We aimed to develop a maturity model that describes a roadmap toward organizational functions and processes that help health care systems use CDS more effectively to drive better outcomes. We developed a maturity model for CDS operations through discussions with health care leaders at 80 organizations, iterative model development by four clinical informaticists, and subsequent review with 19 health care organizations. We ceased iterations when feedback from three organizations did not result in any changes to the model. The proposed CDS maturity model includes three main “pillars”: “Content Creation,” “Analytics and Reporting,” and “Governance and Management.” Each pillar contains five levels—advancing along each pillar provides CDS teams a deeper understanding of the processes CDS systems are intended to improve. A “roof” represents the CDS functions that become attainable after advancing along each of the pillars. Organizations are not required to advance in order and can develop in one pillar separately from another. However, we hypothesize that optimal deployment of preceding levels and advancing in tandem along the pillars increase the value of organizational investment in higher levels of CDS maturity. In addition to describing the maturity model and its development, we also provide three case studies of health care organizations using the model for self-assessment and determine next steps in CDS development.
Individualized Ablation of Hepatocellular Carcinoma: Tailored Approaches across the Phenotype Spectrum
Authors: Devcic Zlatko , Elboraey Mohamed , Vidal Lucas , Mody Kabir , Harnois Denise , Patel Tushar , Toskich Beau B. 
Published: October 2019

AbstractAblation is now recommended by international guidelines for the definitive treatment of hepatocellular carcinoma (HCC). Extensive clinical studies have demonstrated outcomes comparable to surgical resection with shorter hospital stays, decreased costs, and improved quality of life. Successful ablation requires complete treatment of both tumor and margin while preserving critical adjacent structures. HCC exhibits highly variable presentations in both anatomic involvement and biology which have significant implications on choice of ablative therapy. There are now abundant ablation modalities and adjunctive techniques which can be used to individualize ablation and maximize curative results. This article provides a patient-centered summary of approaches to HCC ablation in the context of patient performance, hepatic reserve, tumor phenotype and biology, intra- and extrahepatic anatomy, and ablation technology.
Malignant Transformation of an Enchondroma of the Hand: A Case Report
Authors: Vegas María Jesús Rivera 
Published: October 2019

AbstractWe present the case of the transformation of an enchondroma in the middle phalanx of the fourth finger of the left hand into a chondrosarcoma. The patient presented a lesion with clinical history, examination, and radiology findings consistent with an enchondroma, which was conservatively treated. Two years later, the patient came for a medical visit with a clinical and radiological variation of the lesion. Computed tomography scans and biopsy revealed a lesion with sarcomatous degeneration which was confirmed after the controlled amputation of the fourth finger. The malignant transformation potential of an enchondroma must be considered.
Radial Forearm Free Tissue Transfer to Clival Defect
Authors: Moy Jennifer D. , Gardner Paul A. , Sridharan Shaum , Wang Eric W. 
Published: October 2019

Abstract
Introduction Reconstruction of craniocervical junction (CCJ) defects after endoscopic endonasal skull base surgery (ESBS) remains challenging, despite advancements in vascularized intranasal and regional flaps. Microvascular free tissue transfers have revolutionized reconstruction in open skull base surgery but have been utilized rarely in ESBS. We describe the use of a radial forearm free flap (RFFF) for reconstruction of a recalcitrant CCJ defect after resection of a clival chordoma.
Case Report A 54-year-old female who underwent ESBS for a clival chordoma complicated by a C1–C2 epidural abscess after proton beam therapy presented with pneumocephalus 4 years after her resection (Fig. 1). At the CCJ, she developed a 1-cm skull-base defect. An occult cerebrospinal fluid (CSF) leak persisted despite an extracranial pericranial flap and a lateral nasal wall flap. Her definite reconstruction was a RFFF inset through a transmaxillary approach. Using a maxillary vestibular incision, anterior, lateral, and medial maxillotomies allowed the introduction of the flap into the nasal cavity and the passage of the RFFF pedicle across the posterior maxillary wall, into the premassateric space and to the facial vessels at the mandible. An endonasal inset supplemented with transoral suturing of the distal end of the flap to the posterior oropharynx halted further CSF egress. Vascularization of the flap was confirmed with intraoperative indocyanine green angiography and postoperative computed tomography (CT) angiography and magnetic resonance imaging (MRI).
Conclusion A RFFF inset through a transmaxillary approach to the facial vessels has an adequate reconstructive surface and pedicle to cover the central and posterior fossa skull base after ESBS (Fig. 2).The link to the video can be found at: https://youtu.be/rQ5vJKyD5qg.
The FlexNett Simulator
Authors: Tangrand Kristoffer , Bremdal Bernt 
Published: October 2019

Abstract
This paper documents research conducted in the Norwegian FLEXNETT project. It describes a new tool that was developed to study the future impact of prosumers with PV panels on the grid in Norway and the potential energy flexibility that lies with residential prosumers. Systematic use of energy flexibility can be an important instrument for managing peak loads and voltage problems in weak power grids. The influx of distributed energy resources can amplify this problem, but also help to resolve it. Self-balancing neighborhoods can be very attractive. This implies that loads related to energy demands can be curtailed and leveled out by different controllable devices or managed by using local energy production in the area to reduce the impact on the general distribution grid. The simulation tool is GIS based and can be applied to study the situation related to a single household, a neighborhood or in a specific transformer area. Unlike similar tools that address production yields over a period, the FLEXNETT Simulator addresses production and energy dynamics down to every 10 minutes. Due to the relatively low solar angle in Norway and rapidly changing weather these dynamics can be very prominent and induce local impact that is specific to a house or a neighborhood. The paper further describes how a recurrent neural network has been used as an engine to produce realistic values for the simulator.
Parametric study for the long term energetic performance of geothermal energy piles
Authors: Ferrantelli A , Fadejev J , Kurnitski J 
Published: October 2019

Abstract
Geothermal energy constitutes an important renewable resource that will become increasingly prominent in future constructions. A common method of extraction and usage consists of installing, inside the foundation piles of buildings, U-shaped heat exchangers called “energy piles”.
In this paper such installations are addressed by means of a full parametric study, performed for a hall-type commercial building in a cold climate. By computing the transient heat transfer between energy piles and ground for a period of 20 years, guidelines for a preliminary sizing of the geothermal system as a whole are provided. These are valid for this specific building and climate, for a clay-type soil and without assuming thermal storage.
A highly nonlinear behaviour of the expected yield in relation to pile separation and evaporator extraction power is observed. Furthermore, 15m-long piles are found to be more efficient than those with double length, a smaller extraction power seems to be more favourable and differences in the pile diameter have little impact for heat transfer.
A geothermal system sizing guide, which is useful for a preliminary quantitative test prior to any installation, is introduced. Even though our specific results are valid only for a commercial hall-type building in Finland, our procedure is qualitatively general and can be utilized for any given building type and climate zone.
The Norwegian ZEB definition and lessons learnt from nine pilot zero emission building projects
Authors: Andresen Inger , Wiik Marianne Kjendseth , Fufa Selamawit Mamo , Gustavsen Arild 
Published: October 2019

Abstract
In the frame of the Norwegian Research Centre on Zero Emission Buildings, nine real-life zero emission pilot building projects were initiated during the period of 2009 to 2017. Eight of the pilot building projects have been constructed and are currently in use, whilst one of them is still in the planning phase. All the pilot projects have been followed up by researchers during the design, construction, and operation phases, by e.g. analyses of construction documents, and post-occupancy surveys. The main lessons learnt from this work are presented in this paper. They include the importance of an integrated design process, having clear goals and associated assessment methods, following a strategy based on ‘trias energetica’, as well as choosing locally sourced materials with low embodied carbon and long service lives, and increasing the focus on the users.
Web tool for quantitative sustainability evaluation of hygro-thermally optimized insulation solutions
Authors: Walther S , Birkved M , Perkov T H , Bjarløv S P 
Published: October 2019

Abstract
This study is part of the EU funded project RiBuild and aims to create a web tool for supporting decisions relating to energy retrofits of historic buildings. The web tool provides a quantitative sustainability evaluation of hygro-thermally optimized insulation solutions through a greenhouse gas (GHG) emissions indicator. The study presents LCAs of five insulation systems for installation in historic buildings. The web tool accommodates 160 locations in seven countries and generates 210,180 impact profiles by combining insulation system, installation location, and heating systems. In 2 % of the scenarios, the induced impacts exceed the avoided impacts. Across all analyses, the mineral wool insulation system is the least GHG intensive solution. This study illuminates that the environmental justification of internal insulation depends on the geographical location of installation and the installed heating system in the retrofitted building. To further improve the sustainability performance of energy retrofits in historic buildings, the implementation of insulation recycling solutions and measures for reducing production impacts of insulation systems are needed.
Local energy markets as a solution for increased energy efficiency and flexibility
Authors: Ilieva I , Bremdal B , Lopez A A S de la Nieta , Simonsen S H 
Published: October 2019

Abstract
With increasing share of distributed renewable energy resources in the grid and arising energy consumer awareness on environmental challenges new market models are sought where energy can be traded in an efficient and end-user centric way. This trend, together with the increasing consciousness on the benefits of local consumption and production has given rise to an increased focus on local energy market structures. Within the E-REGIO project, funded through the ERA-Net Smart Grid Plus initiative, local energy markets have been paid particular attention. This paper discusses opportunities associated with local energy trading, as verified through the E-REGIO local energy system pilot - Skagerak EnergiLab in Norway. Embracing, among others, local loads, energy storage system, PV generation and a large consumer (stadium facility), the pilot-based simulations have produced some useful insides on the implementation of local energy markets and have helped collect learnings that can be of benefit for future local energy market establishments.
Influence of smart lighting control on the lifetime of high power LED luminaires
Authors: Askola Janne , Baumgartner Hans , Pulli Tomi , Kärhä Petri , Ikonen Erkki 
Published: October 2019

Abstract
LED lighting and smart controlling can decrease the consumption of electric power in zero or positive energy buildings. This study demonstrates that cyclic dimming, which appears in smart controlling, e.g. through occupancy sensing, might have an effect on the luminaire lifetimes and failure rates. Two different types of LED luminaires were aged in 30-s cycled dimming and undimmed modes. The manufacturer-specified lifetimes for both luminaire types were 100 000 hours. For one of the luminaire types, four out of five cycled units failed before 30 000 operating hours. For the uncycled luminaires, the lifetimes estimated from the measurements were over 100 000 hours. For the other type, the estimated lifetimes were 75 000 hours and 64 000 hours for uncycled and cycled luminaires, respectively.
Thermal conductivity of high-performance insulation - a laboratory study. Realistic design values for use in energy-efficient buildings
Authors: Sletnes Malin , Elvebakk Kristin , Gaarder Jørn Emil , Rognvik Egil , Grynning Steinar 
Published: October 2019

Abstract
Aerogel insulation blankets could be the solution to some of the challenges encountered when designing (energy efficient) buildings. However, uncertainties regarding performance in different applications and environments may limit their use in cases where they could otherwise be employed to advantage. The purpose of this study was to examine how to best adapt European standards for the measurement of thermal insulation properties to aerogel insulation and highlight important aspects to be aware of when evaluating material parameters. We have systematically varied measurement parameters for thermal conductivity and compressive strength to map the impacts on reported material properties. Furthermore, we have compared the measurement conditions to actual conditions in selected building applications. In conclusion we propose that the European (EN) standard for measuring compression behavior for insulation materials should be revised and clarified with regards to materials that do not exhibit a clear elastic domain. We also suggest that the thermal conductivity of aerogel insulation blankets should be measured with a slight compressive load on the material, but that the calculation of the thermal conductivity should nevertheless be based on the measured sample thickness.
Development of a Greenlandic sustainable index for residential buildings
Authors: Labansen Martin Erik , Bastien Diane 
Published: October 2019

Abstract
Globally, there has been a rising focus on improving the sustainability of buildings. Reaching zero net greenhouse gas emissions or producing excess renewable energy throughout the entire lifetime of a building is now clearly possible and certainly worth aiming for. However, in remote Nordic regions like Greenland, current building practices are so far away from these targets that setting intermediary goals is the only option for moving forward in the construction industry. Besides, remote Nordic regions are facing different challenges that are not considered into current building certification schemes, making some practices that can be highly sustainable in some regions inapplicable or even detrimental there. It would be highly desirable to have a certification scheme more accessible for improving current building practices in remote Nordic regions. For a sustainability index to be widely adopted in such a context, it should be relatively simple and straightforward to implement. This contribution presents the Greenlandic Sustainable Index (GSI) for residential buildings, which was developed with the goal to be simple to implement while being ambitious in terms of level of performance. This index is composed of three main categories: Economical, Social and Environmental sustainability.
Tracing the environmental impact origin within the existing building portfolio of prevailing building typologies
Authors: Rønholt Julie , Malabi Eberhardt Leonora Charlotte , Birkved Morten , Birgisdottir Harpa , Bey Niki 
Published: October 2019

Abstract
As circular economy (CE) is becoming a growing focus in the building industry due to the industries large resource consumption, waste production and environmental impacts a better understanding of buildings material composition, resource consumption and resulting environmental performance becomes increasingly important in order to support the transition towards CE. The research presented here is a stepping stone in order to investigating the existing building portfolio and the conducted analysis. It is used to get further information on what is included and where there is lack of information, in order to understand what is missing or what is needed to develop CE design strategies. Although, life cycle assessment (LCA) is increasingly used by the industry to assess these aspects, the lack of a systematic analytical approach as well as the high building complexity and diversity between buildings limits generalised knowledge from these studies. However, it is assumed that there are certain commonalities between the existing portfolio of prevailing building typologies which can be deducted. The study at hand is a part of a larger research project that aims at developing industry specific tools to support designers and decision makers select CE design strategies that improve the environmental performance and resource consumption of buildings. On the basis of a comprehensive systematic literature review (SLR) of whole building LCAs the paper at hand aims at tracing the environmental impact origin within the existing building portfolio of prevailing building typologies. To identify potentially important building parameters relevant to the resulting environmental impact performance and resource consumption of different building typologies. Based on 39 building LCA case studies that matched the specific inclusion and exclusion criteria of the SLR a focus on global warming and climate change was detected. It was found that even though buildings have different characteristics (size, typology, storeys, reference study period and location), for most of the buildings’ environmental impacts were predominantly related to the production of structurally important concrete components e.g. the structural frame, the external envelope, floor slabs and walls. To point towards which CE design strategies should be used to improve the environmental performance of buildings; the environmental information from the studies was insufficient due to lack of detailed information.
Recognizing of Building Components to Achieve Green Performance for Renovation and Retrofitting Works
Authors: Juliardi R D , Misnan M S , Khalid A G , Haron L 
Published: October 2019

Abstract
Renovation and retrofitting have differing meanings. The term renovation refers to the process of returning something to a good state of repair. In the construction industry, improvement relates to the method of improving or modernizing an old, damaged, or defective building. The opposed to a term of retrofitting which is providing something with a component or feature not fitted initially. Retrofitting means giving something with a part or not installed during manufacture or adding something that it did not have when first constructed. Otherwise, it used as improving the health of occupants or increasing the building adaptability, durability, and resiliency. The strategy of green achievement is the purpose of the research. This state of the art is providing how researchers to understand the achievement strategy from building components. To provide a clear overview for the reader, which are building components in Green Building. Then Green building is one of the measures forward to mitigate significant impacts of the building stock on the environment, society, and economy. Professional for respondents taken from three which has differed on AMSL and climate, exploring for knowledge and practices profiles. However, this paper consists of a critical review of the existing body of knowledge of researches related to the strategies of green building achievement. The research themes and findings identified. These universal themes are the definition and scope of renovation and retrofitting on green building, and discussions approach to achieve green buildings by researchers how recognizing the building comIponents. It found that the emphasis played predominately focus on knowledge of professional role as the aspects which are affecting green building achievement. Future research opportunities were identified, such as climatic of all countries to consider green building assessment tools and future-proofing on preconstruction. We suggest developing an awareness of managing and controlling preconstruction work for achieving green achievement. Moreover, it could develop to the next research on developing a strategy on green construction for construction management and project management.
Antibacterial Effectiveness Of Formulations Nanoemulsion Cratoxylum Glaucum Korth. Extract
Authors: Enggiwanto S , Riyani N , Pratama Y , Roanisca O , Mahardika R G 
Published: October 2019

Abstract

Cratoxylum glaucum Korth. is a members of the family Hypericaceae which are spread in Indonesia, one of which is found in the forest of the Bangka Belitung Islands. Cratoxylum glaucum Korth is often used by the people of Bangka Belitung as a flavoring ingredient from ancient times until now it is still consumed and utilized by people around Bangka Belitung. One source of natural antioxidants is the top of the crust. The effort of increasing its activity is very strong, so in this study we try to develop extraction of Cratoxylum glaucum made in the form of nanoemulsion. This study aims to determine the comparison of Cratoxylum glaucum extract in nanoemulsion preparations with extracts as antibacterial. Nanoemulsion is made with the composition of Virgin Coconut Oil (VCO) as an oil phase, tween 80 as surfactant and aquades as a water phase with a ratio of 2.5: 10: 25. The nanoemulsion extract of Cratoxylum glaucum have a size 422.9 nm and PI value 0.493. The antibacterial activity of nanoemulsion formulation has inhibitory growth power in moderate categorized Staphylococcus aureus bacteria, whereas in the extract of Cratoxylum glaucum it has the inhibitory growth of active Staphylococcus aureus bacteria.