bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustic Metamaterial Composite Structures Based on Multistage Fano Resonance for Noise Attenuation
Authors: Zhang Xinhao , Geng Mingjing , Zhao Caiyou , Niu Yawen , Wang Ping 
Published: December 2024

AbstractAn acoustic metamaterial composite structure (AMCS) for Noise attenuation is proposed based on the principle of multilevel Fano resonance. The AMCS is composed of a type I labyrinthine metamaterial in the outer ring, a six‐channel spiral metamaterial in the middle ring, a type II labyrinthine metamaterial in the inner ring, and a porous acoustic‐absorbing metamaterial in the inner inlay. The simulation results show that the average sound attenuation reaches 17 dB in the range of 0–5000 Hz due to the multilevel Fano resonance effect during the sound wave propagation process. Meanwhile, the sound field distribution law and the flow diagram also verify that the multilevel Fano resonance mechanism is the key factor causing broadband sound absorption. Then, the AMCS is fabricated by 3D printing, and the simulation results are verified by the acoustic experiment for AMCS cell. Additionally, to further enhance the overall sound attenuation in the railroad noise field, a simulation model of the combined train‐track‐AMCS sound barrier coupling is developed, and it is found that the AMCS type sound barrier can effectively block the propagation of wheel‐rail noise from different angles, and it possesses a noise reduction of 20 dB in all frequency bands.
Identification and Passivation of D‐Center in 4H‐SiC: A First‐Principles Study
Authors: Liu Shuai‐Shuai , Zhang Hai‐Shan , Kang Fang‐Jing , Peng Ze , Guo Shao‐Qiang , Lyu Juan , Gong Jian 
Published: December 2024

AbstractAs a deep acceptor defect in 4H‐SiC, the D‐center related to boron impurities has attracted much attention. However, there are still some disagreements regarding the origin of the D‐center, as well as a lack of sufficient understanding of the related optical transitions and carrier capture processes. In this work, based on first‐principles calculations, the optoelectronic properties of boron‐related point defects in 4H‐SiC is systematically investigated, and the passivation of hydrogen on BC defects is also evaluated. The calculated 0/−1 transition levels of substitutional defect BC are very close to the activation energies of the D‐center observed in experiments. Furthermore, the photoluminescence (PL) peak positions and non‐radiative hole capture cross‐section of BC defects calculated are all in good agreement with the experimental values of the D‐center. This confirms that the substitutional defects BC are responsible for the D‐center in 4H‐SiC. These calculation results reveal that the hydrogen atom in 4H‐SiC prefers to combine with the BC defects and to passivate the deep acceptor level within the bandgap in 4H‐SiC by forming the BC‐H complex. This work effectively identifies and passivates the D‐center in 4H‐SiC, providing valuable insights for improving the performance of various semiconductor materials affected by deep defects.
Programmable Modular Assembly of Homochiral Ir(III)‐Metallohelices to Reverse Metallodrug Resistance by Inhibiting CDK1
Authors: Li Xuezhao , Zhao Xing , Wang Xingyun , Xiong Anxian , Wang Zhicheng , Shi Zhuolin , Zhang Jingyi , Wang Hanlin , Wei Wei , He Cheng , Ma Jiajia , Guo Zijian , Duan Chunying , Zhao Jing , Wang Xiuxiu 
Published: December 2024

AbstractDrug resistance is a major cause of cancer recurrence and poor prognosis. The innovative design and synthesis of inhibitors to target drug‐resistance‐specific proteins is highly desirable. However, challenges remain in precisely adjusting their conformation and stereochemistry to adapt the chiral regions of target proteins. Herein, using a stepwise programmable modular assembly approach, we precisely engineered two pairs of homochiral dinuclear Ir(III) metallohelices (Λ2S4‐Hbpy and Δ2R4‐Hbpy, Δ2S4‐Hbpy and Λ2R4‐Hbpy) functionalized with flexible dithiourea linkages. The resulting homochiral metallohelices exhibited significant chirality‐dependent photocytotoxicities, and the enhanced structural compatibility of Δ2S4‐Hbpy with the target cyclin‐dependent kinase 1 (CDK1) contributed to its superior photodynamic therapy efficacy, achieving an outstanding photocytotoxicity index (PI) value of 2.3×104. Interestingly, emerging as a critical mediator in the development of oxaliplatin resistance, CDK1 targeting by Δ2S4‐Hbpy achieved enhanced cellular uptake, anticancer activity, and oncosis‐mediated cell death in oxaliplatin‐resistant HCT‐8/L cells. Mechanistic investigations, including proteomic profiling and CDK1 gene silencing, confirmed the pivotal role of chirality‐selective CDK1 targeting in reversing metallodrug resistance. This study introduces a promising platform for constructing and customizing flexible metallohelices with precise conformation and stereochemistry to target drug‐resistance‐specific proteins, offering innovative insights into the designability of metallodrugs to overcome drug resistance.
Supercritical Ethane Processing of ZIF‐8 Membranes towards Pressure‐Resistant C3H6/C3H8 Separation
Authors: Yu Kunpeng , Ji Taotao , Wu Mingming , Chen Sixing , Gao Yunlei , Yan Jiahui , Meng Shengyan , Hu Wenjing , Fan Xiao , Dong Wenwen , Yin Jianzhong , Liu Yi 
Published: December 2024

AbstractZIF‐8 membranes have shown great promise in industrial‐scale C3H6/C3H8 separation. Nonetheless, sustainable preparation of pressure‐resistant ZIF‐8 membranes remains a grand challenge. In this study, we pioneered the use of supercritical ethane (scC2H6) as reaction medium for preparing pressure‐resistant ZIF‐8 membranes. Membrane growth in neutral organic environment was proven to have less disturbance to structure integrity compared with supercritical CO2 (scCO2). Gas permeation results indicated that obtained ZIF‐8 membrane exhibited an ideal C3H6/C3H8 selectivity of 172.1 with C3H6 permeance of 5.9×10−9 mol ⋅ m−2 ⋅ s−1 ⋅ Pa−1. Of particular note, the membrane maintained stable C3H6/C3H8 selectivity of ~150 with C3H6 flux of ~1.6×10−3 mol ⋅ m−2 ⋅ s−1 at operation pressure of 6 bar, which was significantly different from ZIF‐8 membranes obtained from scCO2 reaction medium. Through combining with advantages of zero pollutant discharge and full ligand recovery, our protocol holds great promise in sustainable preparation of pressure‐resistant ZIF‐8 membranes towards practical application in high‐purity C3H6 production.
Organocatalytic Asymmetric Construction and Application of Axially Chiral Spiro‐bisindoles
Authors: Zhao Hao‐Wen , Jiang Fei , Chen Sihan , Hu Jingliang , Xiang Shao‐Hua , Ding Wei‐Yi , Lu Wei , Tan Bin 
Published: December 2024

AbstractSpiro skeletons have emerged as a privileged class of chiral carriers across various research fields, including asymmetric catalysis and functional materials, due to their remarkable configurational rigidity. However, limited structural diversity of spiro frameworks significantly restricts the expansion of their applications. Here we present a new class of axially chiral spiro‐bisindole frameworks and report their first enantioselective construction via a chiral phosphoric acid‐catalyzed intramolecular dehydrative cyclization reaction. Unlike the classical SPINOL backbone, incorporation of indole moieties in place of phenol enhances the nucleophilicity of ketone substrates, thereby eliminating the need for a tedious pre‐activation process. By leveraging the retained active sites of indole, the resulting highly enantioenriched spiro‐bisindoles can be rapidly transformed into other valuable structures. More importantly, axially chiral fluorescent molecules with good asymmetry factors and quantum fluorescence efficiency are readily accessed, opening a new avenue for developing chiral fluorescent materials. Control experiments demonstrate the pivotal role of both unmasked N−H bonds in achieving good efficiency and enantiocontrol.
A Mutual Information Based Multifeature Pattern Recognition Criterion for Identification and Optimization of Thermally Safe Operating Conditions for Single Diffusion‐Controlled Reactions Occurring in Isoperibolic Liquid–Liquid Semibatch Reactors
Authors: Wang Qiuyu , Yang Guang , Zhu Jiaxing , Zheng Tianshuo , Su Bingbing , Zhang Bo 
Published: December 2024

ABSTRACTPrevention of thermal runaway and establishment of safe‐economic operating conditions are crucial for the practical operation of single diffusion‐controlled liquid–liquid reactions occurring in isoperibolic semibatch reactors. Hence, in this study, a mutual information‐based multiple feature recognition criterion (MI‐MFR) was innovatively proposed, for which the maximum relevance minimum redundancy approach was introduced in feature screening; in combination with the support vector machine algorithm, various thermal behaviors can be effectively recognized. On this basis, a series of boundary diagrams were established accordingly, the impact of the variation in model parameters on which was systematically explored. Subsequently, an improved generalized thermal safety region was developed by introducing the upper thresholds in normal and cooling failure scenarios. Meanwhile, the robustness and progressiveness of the established MI‐MFR criterion were confirmed by comparison with other conventional criteria. Finally, MI‐MFR‐based procedures were constructed to identify thermal behaviors and optimize safe‐economic operating conditions in practices, based on which the optimum operating conditions of toluene mononitration were obtained.
Superconducting Nanowire Detection of Neutral Atoms and Molecules via Their Internal and Kinetic Energy in the eV Range
Authors: Strauß M. , Gourgues R. , Mauser M. F. X. , Kulman L. , Castaneda M. , Fognini A. , Shayeghi A. , Geyer P. , Arndt M. 
Published: December 2024

AbstractSuperconducting nanowires are widely recognized as exceptional sensors in photonics, information processing, and astronomy. Even a single infrared photon can break Cooper pairs, generate a hot spot and trigger a measurable quantum phase transition. Here, it is demonstrated that this detection capability is far more versatile. Ultrathin nanowires are shown to be sensitive to the internal energy of atoms as well as to the kinetic energy of neutral molecules, here within the energy range of 10–20 and 3–6 eV, respectively. Superconducting nanowires achieve higher detection quantum yields than channel electron multipliers in the detection of metastable atoms and they surpass the efficiency of secondary electron detectors by more than a factor of 106 in the detection of molecules at impact energies below 5 eV. This remarkable sensitivity paves the way for new applications in atomic and molecular beam physics, establishing nanowires as a crucial tool for future precision measurements.
Pseudosuchia: Masters of survival and diversification
Authors: Sena Mariana Valeria de Araujo , Woodward Holly Noelle , Cubo Jorge 
Published: December 2024

AbstractIn the context of an increasing interest for Pseudosuchia, we have compiled a Special Issue, comprising 14 collaborative studies that deepen our understanding of pseudosuchian evolution. These contributions range from the description of a new taxon to exhaustive reviews of thermometabolism, morphological adaptation, systematics, and detailed investigations into ontogeny, paleoneurology, paleohistology, and paleobiology. Through these papers, we explore the evolutionary history of pseudosuchian archosaurs, spotlighting their rise and diversification following the end‐Permian mass extinction.
Comparing Risks for Binomial Reliability Assurance Test Planning
Authors: Kim Hyoshin , Wilson Alyson G. 
Published: December 2024

ABSTRACTBalancing consumer's and producer's risk is an important consideration when planning tests. Instead of focusing on finding a single best test plan, we introduce a general framework to systematically identify a set of binomial test plans by leveraging the inverse relationship between the two risks. The framework is applied to compare a variety of assurance testing frameworks, including classical tests, and Bayesian reliability assurance tests such as the Bayesian assurance test, the assurance reliability demonstration test, and the coverage criterion test. Efficient algorithms are presented to compute the set of test plans, providing practitioners with a comprehensive range of options to choose from. In addition, we include a comparison to the sequential probability ratio test. We also provide formal proofs for the inverse relationship between consumer's and producer's risk in Bayesian reliability assurance tests that underlie our algorithms. A case study is presented to illustrate the framework's application and compare the risks associated with different test plans.
Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ‐3‐derived Langerhans cells
Authors: Simpson Amy , DiColandrea Teresa , Przyborski Stefan 
Published: December 2024

AbstractAir pollution is an exogenous stressor known to have a detrimental impact on skin health through the induction of inflammation; however, the direct effect of topical pollution exposure is still being elucidated. Human skin equivalents (HSE) aim to reproduce in vitro the structure and function of the native skin tissue. However, HSEs typically lack skin‐resident immune cells, which could play a key role in the inflammatory response induced by pollution exposure. We outline the development of a HSE‐containing MUTZ‐3‐derived Langerhans cells (MUTZ‐3‐LCs), which show dendritic morphology and Langerhans cell marker expression. We demonstrated that HSE‐containing MUTZ‐3‐LC have lower basal levels of proinflammatory cytokines, but topical stimulation with allergens and irritant compounds induced a greater inflammatory response in these models compared to HSE without immune cells. To study the effect of pollution, we created a technique to apply diesel particulate matter (DPM) to HSEs. Though our microscopic analysis demonstrated that DPM does not penetrate the stratum corneum, we showed that DPM did induce production of proinflammatory cytokines, but notably only in HSEs containing MUTZ‐3‐LCs. These data suggest that topical exposure to air pollution can induce cutaneous inflammation and that skin‐resident immune cells contribute to this response. This highlights the significance of immune‐competent HSEs to the study of exogenous stressors in vitro.
Harnessing Bioluminescence: A Comprehensive Review of In Vivo Imaging for Disease Monitoring and Therapeutic Intervention
Authors: Sangeetha B. , Leroy K. I. , Udaya Kumar B. 
Published: December 2024

ABSTRACTThe technique of using naturally occurring light‐emitting reactants (photoproteins and luciferases] that have been extracted from a wide range of animals is known as bioluminescence imaging, or BLI. This imaging offers important details on the location and functional state of regenerative cells inserted into various disease‐modeling animals. Reports on gene expression patterns, cell motions, and even the actions of individual biomolecules in whole tissues and live animals have all been made possible by bioluminescence. Generally speaking, bioluminescent light in animals may be found down to a few centimetres, while the precise limit depends on the signal's brightness and the detector's sensitivity. We can now spatiotemporally visualize cell behaviors in any body region of a living animal in a time frame process, including proliferation, apoptosis, migration, and immunological responses, thanks to BLI. The biological applications of in vivo BLI in nondestructively monitoring biological processes in intact small animal models are reviewed in this work, along with some of the advancements that will make BLI a more versatile molecular imaging tool.
Modeling Approach to Mechanical Gas Dewatering of Filter Cakes With Non‐Uniform Cake Height
Authors: Sauer Florian , Henn Hendrik , Hoffner Bernhard 
Published: December 2024

AbstractGas dewatering of filter cakes with non‐uniform cake height is investigated. Two‐phase fluid flow is described in a continuum approach by conservation of mass and momentum of both phases. A priori measurements of capillary pressure and relative permeability allow to predict the impact of different cake geometries on the dewatering kinetics. Transient saturation and flow velocity fields within the filter cakes are calculated and discussed. No measurable effect on the mean saturation is observed in the investigated cases. However, the total flux, which needs to be handled by the vacuum pump to prevent a drop of the pressure difference during gas dewatering, is affected significantly by cake geometry. Model predictions are compared to experimental data from preceding publications and show reasonable agreement within the margin of error.
Endophyte effects on drought tolerance of turf‐type tall fescue
Authors: Boyle Paige E. , Richardson Michael D. , Karcher Douglas E. , Hignight Kenneth W. , Hignight Debra , Secks Margaret E. 
Published: December 2024

AbstractThe response of tall fescue [Schedonorus arundinaceus (Schreb.) Dumort.], infected with fungal endophytes, and subjected to drought stress has varied, presumably due to variability in host–endophyte associations. Much of this research has focused on forage ecotypes; less is known about the effects of endophytes on managed turfgrasses. The objective of these trials was to determine if the presence of fungal endophytes in turf‐type tall fescue provides an advantage to the host grass when exposed to drought conditions. Five endophyte‐free and endophyte‐infected field populations were established in Fayetteville, AR, and Albany, OR. A greenhouse trial was also established in Albany. Turf was subjected to drought and lightbox photos were evaluated to determine days until 75%, 50%, and 25% green cover. Overall, endophyte infection had no consistent effect on the drought response of tall fescue. Although there was no effect on drought response, endophyte infection in turf may confer other benefits, and may still be a valuable tool for turfgrass management.
Enhanced Blue Emission via Pressure Treatment of an Organic‐Inorganic Zinc Bromide†
Authors: Huang Shi‐Shuang , Li Zi‐Ying , Zhang Ying , Yang Hai‐Run , Liu Yungui , Azeem Muhammad , Feng Rui , Li Wei 
Published: December 2024

Comprehensive SummaryPressure‐treatment has been shown to be an effective means to enhance fluorescence of organic‐inorganic halides though it is only limited to few examples. Here, we report the pressure‐dependent structural evolution and emission enhancement upon compression treatment of a zero‐dimensional halide, BTPP2ZnBr4 (BTPP = Benzyl triphenyl phosphonium). Compared to the uncompressed BTPP2ZnBr4 crystal, the pressure‐treated sample shows a maximum 7‐fold intensified fluorescence at ambient conditions while maintaining the wide‐spectrum blue emission feature. This significantly boosted emission is attributed to the pressure‐induced irreversible structural distortion which effectively reduces the non‐radiative recombination. This work demonstrates the promising potential of pressure treatment in achieving bright organic‐inorganic halide emitters and other molecular fluorescent materials.
Exome Sequencing Identified Susceptible Genes for High Residual Risks in Early‐Onset Coronary Atherosclerotic Disease
Authors: Wu Runda , Su Ya , Liao Jianquan , Shen Juan , Ma Yuanji , Gao Wei , Dong Zheng , Dai Yuxiang , Yao Kang , Ge Junbo 
Published: December 2024

ABSTRACTAimsDespite the tremendous improvement in therapeutic medication and intervention for coronary atherosclerotic disease (CAD), residual risks remain. Exome sequencing enables identification of rare variants and susceptibility genes for residual risks of early‐onset coronary atherosclerotic disease (EOCAD) with well‐controlled conventional risk factors.MethodsWe performed whole‐exome sequencing of subjects who had no conventional risk factors, defined as higher body mass index, smoking, hypertension and dyslipidemia, screened from 1950 patients with EOCAD (age ≤ 45 years, at least 50% stenosis of coronary artery by angiography), and selected control subjects from 1006 elder (age ≥ 65 years) with < 30% coronary stenosis. Gene‐based association analysis and clinical phenotypic comparison were conducted.ResultsSubjects without defined conventional risk factors accounted for 4.72% of young patients. Totally, 6 genes might be associated with residual risk of EOCAD, namely CABP1 (OR = 22.19, p = 0.02), HLA‐E (OR = 22.19, p = 0.02), TOE1 (OR = 33.6, p = 0.002), HPSE2 (OR = 11.1, p = 0.04), CHST14 (OR = 22.19, p = 0.02) as well as KLHL8 (OR = 22.19, p = 0.02). Phenotypic analysis displayed the levels of low‐density lipoprotein cholesterol in carriers of mutations from CABP1, HLA‐E, TOE1, and HPSE2 were significantly elevated compared to noncarriers. Notably, extracellular matrix‐associated CHST14 and fibrinogen‐associated KLHL8 both displayed possible correlation with increased neutrophil proportion and decreased monocyte percentage (both p < 0.05), exerting potential effects on the residual inflammatory risks of EOCAD.ConclusionThe study identified six genes related to dyslipidemia and inflammation pathways with potential association with residual risk of EOCAD, which will contribute to precision‐based prevention in these patients.Trial RegistrationThe GRAND study was registered at www.clinicaltrials.gov on July 14, 2015, and the registry number is NCT 02496858.
The Evaluation of Glyceryl C3‐Azolyl‐Thiogalactosides as Galectin‐1 and Galectin‐3 Ligands
Authors: Prouza Vít , Zýka Jakub , Kozák Jaroslav , Magdolenová Alžbeta , Pohl Radek , Parkan Kamil 
Published: December 2024

AbstractGalectins are a family of galactoside‐binding proteins involved in various pathophysiological processes, which makes them attractive targets for drug discovery. The derivatization of d‐galactose at C3 and C1 positions has been shown to increase the affinity of synthetic galectin antagonists. In this study, two small libraries of d‐galactose derivatives have been designed and synthesized. The first series involved the development of novel aromatic 3‐azolyl‐3‐deoxy‐d‐galactopyranoses. The second series consisted of epimeric analogs of glyceryl β‐S‐d‐galactopyranosides, which were also derivatized. Binding‐affinity evaluations for galectin‐1 and galectin‐3 have revealed that galactose analogs from both series have potential for further optimization. Notably, a combination of modifications at the C3 position of the galactose ring and on the aglycone has led to the identification of promising galectin inhibitors, specifically the compounds 29R and 32S.
Eco‐Friendly and Ready‐To‐Market Polyurethanes: A Design of Experiment‐Guided Substitution of Toxic Catalyst and Fossil‐Based Isocyanate
Authors: Viada Gabriele , Mariotti Nicole , Galliano Simone , Menozzi Alberto , Barolo Claudia , Bonomo Matteo 
Published: December 2024

AbstractIn this contribution, we tackle the replacement of the Hg‐based catalyst and fossil‐derived isocyanate precursors toward the formulation of a more sustainable polyurethane thermosetting resins (PUs), emulating the performance of a fully fossil‐based one employed in industrial encapsulation of optoelectronics. A mixed Bi−Zn catalyst and a 71 % bio‐based isocyanate are exploited at this aim through multivariate chemometric approaches, namely Design of Experiment (DoE). DoE allows us to investigate the effect of different formulation factors on selected parameters, such as the film flexibility and transparency or the gel time. More in detail, it is found that a low amount of Zn‐rich catalytic mixture leads to a ready‐to‐market polyurethane only when a fossil‐based isocyanate is used. Differently, PUs formulated with bio‐based isocyanate, albeit showing a higher bio‐based content, present an insufficient optical purity, jeopardizing their market acceptability. Nevertheless, adding a negligible amount of a specific long chain fatty acid as reactivity modulator in the formulation leads to a bubbles‐free and ready‐to‐market resin showing an impressive 65 % w/w content of circular and bio‐based components.