bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats
Authors: Jaiswal Pawan , Mandal Mukesh , Mishra Awanish 
Published: July 2020

AbstractFluoride is the second largest contaminant of drinking water. Fluoride toxicity is a major concern in the endemic areas where a high amount of fluoride is present in ground water. Oxidative stress has been proposed to be one of the mechanisms of fluoride‐induced toxicity. Antioxidant‐rich food has been found to alleviate fluoride‐induced toxicity. Therefore, in this study, we have examined the effect of hesperidin on fluoride‐induced neurobehavioral changes in rats. In the current study, male Sprague‐Dawley rats were exposed to sodium fluoride through drinking water (120 ppm). Hesperidin (200 mg kg−1 d−1; per os) was administered either alone or in combination with fluoride‐containing drinking water. Bisphinol A diglycidyl ether (BADGE) was used as peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) antagonist and was administered (10 mg kg−1 d−1; intraperitoneal injection) with/without hesperidin along with fluoride‐containing drinking water. The behavioral changes in the animals were assessed by analyzing rotarod test, novel object recognition test, and forced swim test (FST). After 8 weeks, animals were killed to isolate blood and brain for monitoring biochemical changes. The 8‐week exposure of fluoride resulted in motor impairment as observed with reduced fall time in rotarod test, memory impairment as observed with reduced preference index in novel object recognition test, and depression‐like behavior as observed with reduced mobility index in the FST. Treatment with hesperidin improved neurobehavioral impairment along with restoration in brain biochemical changes (ie, acetylcholinesterase activity and antioxidant and oxidative stress parameters). The protective effect of hesperidin was reversed by coadministration of BADGE. The neuroprotective effect of hesperidin appears to be contributed through PPAR‐γ receptor.
Excess hydrogen peroxide inhibits head and foot regeneration in hydra by affecting DNA repair and expression of essential genes
Authors: Haval Gauri A. , Pekhale Komal D. , Perween Nusrat A. , Ghaskadbi Surendra M. , Ghaskadbi Saroj S. 
Published: July 2020

AbstractReactive oxygen species (ROS) are necessary for various cellular processes. However, excess ROS cause damage to many biological molecules and therefore must be tightly regulated in time and space. Hydrogen peroxide (H2O2) is the most commonly used ROS as second messenger in the cell. It is a relatively long‐lived freely diffusible signaling molecule during early events of injury. In the Cnidarian hydra, injury‐induced ROS production is essential for regeneration to proceed. In the present study, we have examined influence of varying exposure to H2O2 on head and foot regeneration in the middlepieces of trisected hydra. We find that longer (4 hours) exposure to 1 mM H2O2 inhibits both head and foot regeneration while shorter exposure (2 hours) does not. Longer exposure to H2O2 resulted in extensive damage to DNA that could not be repaired, probably due to suboptimal induction of APE1, an enzyme necessary for base excision repair (BER). Concomitantly, genes involved in activation of Wnt pathway, necessary for head regeneration, were significantly downregulated. This appeared to be due to failure of both stabilization and transient nuclear localization of β‐catenin. Similarly, genes involved in foot regeneration were also downregulated on longer exposure to H2O2. Thus, exposure to excess ROS inhibits regenerative processes in hydra through reduced expression of genes involved in regeneration and diminished DNA repair.
ELT‐2 promotes O‐GlcNAc transferase OGT‐1 expression to modulate Caenorhabditis elegans lifespan
Authors: Su Liangping , Zhao Tingting , Li Hongyuan , Li Hongmei , Su Xin , Ba Xueqing , Zhang Yu , Huang Baiqu , Lu Jun , Li Xiaoxue 
Published: July 2020

AbstractO‐GlcNAc transferase (OGT) is the enzyme catalyzing protein O‐GlcNAcylation by addition of a single O‐linked‐β‐N‐acetylglucosamine molecule (O‐GlcNAc) to nuclear and cytoplasmic targets, and it uses uridine diphosphate‐N‐acetylglucosamine (UDP‐GlcNAc) as a donor. As UDP‐GlcNAc is the final product of the nutrient‐sensing hexosamine signaling pathway, overexpression or knockout of ogt in mammals or invertebrate models influences cellular nutrient‐response signals and increases susceptibility to chronic diseases of aging. Evidence shows that OGT expression levels decrease in tissues of older mice and rats. However, how OGT expression is modulated in the aging process remains poorly understood. In Caenorhabditis elegans, the exclusive mammalian OGT ortholog OGT‐1 is crucial for lifespan control. Here, we observe that worm OGT‐1 expression gradually reduces during aging. By combining prediction via the “MATCH” algorithm and luciferase reporter assays, GATA factor ELT‐2, the homolog of human GATA4, is identified as a transcriptional factor driving OGT‐1 expression. Chromatin immunoprecipitation‐quantitative polymerase chain reaction and electrophoretic mobility shift assays show ELT‐2 directly binds to and activates the ogt‐1 promoter. Knockdown of elt‐2 decreases the global O‐GlcNAc modification level and reduces the lifespan of wild‐type worms. The reduction in lifespan caused by elt‐2 RNA interference is abrogated by the loss of ogt‐1. These results imply that GATA factors are able to activate OGT expression, which could be beneficial for longevity and the development of therapeutic treatment for aging‐related diseases.
Adsorption of acridine yellow G from aqueous solutions using functionalized graphene nanoplatelets/modified polybutadiene hybrid composite
Authors: Aliyeva Solmaz 
Published: July 2020

AbstractThis paper presents an analysis of adsorption of acridine yellow G (AYG) from aqueous solutions through the use of functionalized grapheme nanoplatelets/modified polybutadiene hybrid composite (FGNPs/MPB). The adsorption of AYG onto FGNPs/MPB was investigated based on the AYG concentration, pH, contact time, temperature, and adsorbent dose. A maximum adsorption capacity was obtained at a pH of 7 (23.7 mg/g), an adsorbent dose of 1.0 g/L (20.8 mg/g), and an initial AYG concentration of 28.5 mg/L (16.9 mg/g). The value of qe of FGNPs/MPB increases with an increase in temperature from 293 to 323 K. Equilibrium isotherm data were analyzed using the Langmuir and Freundlich isotherm models. The Langmuir model best describes the adsorption processes of AYG, which showed that the monolayer adsorption capacity of FGNPs/MBP is 22.9 mg/g. The pseudofirst‐order, pseudosecond‐order, and intraparticle diffusion models were used to study the kinetics of the AYG adsorption onto FGNPs/MPB. The pseudosecond‐order model better described kinetic data for the adsorption of AYG onto FGNPs/MPB. Thermodynamic parameters, such as the Gibbs free energy, enthalpy, and entropy, indicated that the AYG adsorption onto FGNPs/MPB was spontaneous feasible, and endothermic.
Happiness as fairness: The relationship between national life satisfaction and social justice in EU countries
Authors: Di Martino Salvatore , Prilleltensky Isaac 
Published: July 2020

AbstractDespite growing interest in the relation between social justice and life satisfaction, there is a paucity of quantitative investigations linking these two constructs, even in the field of Community Psychology. To bridge this gap, we tested the relationship between the EU Social Justice Index (SJI; 2008–2017) and life satisfaction across 28 European Union (EU) countries, in a series of multilevel multinomial logistic regression models with cumulative logit link function. The SJI proved one of the strongest predictors of national life satisfaction, after controlling for time variation and other well‐established country‐level determinants. Our findings lend support to the hypothesis that social justice is highly related to life satisfaction. We invite scholars to explore this relationship further. We also recommend that EU governments strive to promote fairer social conditions to increase national happiness.
Normal reference values of left atrial volumes and volume‐based functional properties using three‐dimensional speckle‐tracking echocardiography in healthy adults (Insights from the MAGYAR‐Healthy Study)
Authors: Nemes Attila , Kormányos Árpád , Domsik Péter , Kalapos Anita , Ambrus Nóra , Lengyel Csaba 
Published: July 2020

AbstractIntroductionThe present study was designed to define normal reference values of three‐dimensional speckle‐tracking echocardiography (3DSTE)‐derived left atrial (LA) volumes, stroke volumes (SVs), and emptying fractions (EFs) with regard to the cardiac cycle.MethodsThe present study involved 256 healthy adult subjects in sinus rhythm who underwent complete two‐dimensional Doppler echocardiography and 3DSTE at the same time. However, due to inferior image quality, 87 subjects have been excluded. The remaining population sample comprised of 169 patients who gave informed consent to participate in the study.ResultsWhile systolic maximum LA volume and early diastolic preatrial contraction LA volume did not change over age decades, late‐diastolic minimum LA volume decreased and was lowest in subjects aged 40 to 49 years then increased after 50 years. Total atrial EF increased over age decades with a reduction after 50 years. Passive atrial EF showed a significant continuous increase over age decades. Active atrial EF did not change in younger ages and was the highest between ages 40 and 49 years with a significant impairment after 50 years.ConclusionsThis study shows the age‐ and gender‐dependency of normal values of 3DSTE‐derived LA volumes, stroke volumes, and emptying fractions with regard to the cardiac cycle in healthy adult subjects.
Faculty perceptions of student incivility in dental hygiene education
Authors: McCarthy Jennifer L. , Giblin‐Scanlon Lori , Perry Kristeen R. , Boyd Linda D. , Vineyard Jared 
Published: July 2020

AbstractPurpose/objectiveConflict and discourtesy between college students and faculty have become increasingly common in higher education. Fallout from uncivil student encounters can have numerous effects on educators’ overall health and has been shown to negatively impact learning environments. This research assessed the severity and frequency of student incivility in dental hygiene education and explored the relationship uncivil behavior has on faculty feelings of confidence, career satisfaction, and longevity.MethodsCross‐sectional survey research was conducted among dental hygiene educators (n = 601) in the United States and Canada using purposive and snowball sampling. The survey (47‐item) was developed based on the literature and validated prior to administration. Spearman's correlation coefficient was used to assess the relationship between variables and mean item category scores and thematic analysis was used to identify themes for open‐ended questions.ResultsSurvey completion rate was 78% (n = 469). Behaviors ranked mildly uncivil, such as eating/drinking in class, occurred more frequently, and incivility had less impact on faculty confidence with increased age (r = ‐.19; P ≤ 0.01). The level of severity of behaviors did not impact educators; however, how often certain behaviors occurred had some effect. Contemptuous behaviors, such as using a disrespectful/sarcastic tone (r = .34, .32, .31; P ≤ 0.01), had the most impact.ConclusionThis study determined student incivility exists within dental hygiene education. Day‐to‐day, minor uncivil behaviors seemingly take a greater emotional toll than occasional, highly uncivil encounter. Understanding how faculty perceive these behaviors may influence development of management strategies, fostering a sense of career satisfaction for educators.
Biomimetic synthesis of carthamin, a red pigment in safflower petals, via oxidative decarboxylation
Authors: Abe Yuka , Sohtome Takuo , Sato Shingo 
Published: July 2020

AbstractCarthamin, a natural red pigment derived from safflower, was discovered centuries ago and has been utilized in several industries such as dye, food coloring, and natural medicine industries. Although it has been used since Egyptian times, its structural features were only determined in the mid‐1900s when pioneering studies were conducted to elucidate the carthamin structure and assign its stereochemistry. Reproducing the complex biosynthesis of carthamin has been a common research goal since then. However, this has been rendered complex because of the unstable precursors and low yields from the multiple steps involved in the synthesis. Herein, we report the total synthesis of carthamin via a four‐step procedure using (S)‐C‐β‐D‐glucosylquinochalcone as the starting compound. The synthesis involves mild conditions, short reaction time, and readily available compounds. After de‐O‐methylation, condensation, oxidative decarboxylation, and saponification, carthamin was obtained in an overall yield of 9.5% through the proposed method.
The remarkable larval anatomy of Proceratophrys minuta Napoli, Cruz, Abreu and Del‐Grande, 2011 (Amphibia: Anura: Odontophrynidae)
Authors: dos Santos Dias Pedro Henrique 
Published: July 2020

AbstractThe free living larvae of anurans (i.e., tadpoles) are a key element in the evolution and diversification of this group, and as such, their morphology is an important element to understand the phylogenetic relationships of frogs. However, the lack of data on larval morphology prevents us from fully understanding larval evolution in several lineages. The Neotropical genus Proceratophrys currently comprises 39 species, but descriptions of the internal morphology of larvae in this group are rare and restricted to few aspects of their buccopharyngeal cavity, chondrocranium, and muscles. In the present study, I describe the internal anatomy of the tadpole of P. minuta and report a new remarkable myological character state for the species. Given the rarity of this material, the description of this species' buccopharyngeal and musculo‐skeletal elements is based on two tadpoles in developmental stages 30 and 31. Several new apomorphic character states are described: (a) the presence of a conical papilla in the interior of the nostril; (b) a row of five short, conical papilla preceding the tall, postnarial papilla; and (c) the m. mandibulolabialis inserting in the gular skin. This latter feature is a remarkable, newly discovered character state that had never been reported in the literature before and is probably related to a particular feeding habit of the tadpoles of this species. The function of the m. mandibulolabialis in P. minuta is unknown.
Evaluation of ivabradine in left ventricular dyssynchrony and reverse remodeling in patients with chronic heart failure
Authors: Soylu Korhan , Cerik Idris Bugra , Aksan Gokhan , Nar Gokay , Meric Murat 
Published: July 2020

AbstractObjectivesIvabradine is a pharmacological agent used in patients with heart failure and sinus rhythm. Its only known pharmacological effect is to slow the heart rate. In this study, we investigated the impact of ivabradine on dyssynchrony parameters in heart failure patients.MethodsIn this study, we assigned 55 patients taking medication for heart failure to receive ivabradine in addition (Group I). Twenty healthy volunteers comprised Group II. Echocardiographic measurements (dyssynchrony, left ventricular volumes and left ventricular ejection fraction) were taken at baseline, 1 month, and 3 months.ResultsA total of 32 heart failure patients in Group I completed the study. There was significant improvement in dyssynchrony parameters after ivabradine treatment in Group I. Interventricular dyssynchrony (IVD) decreased from 42.0 ± 24.4 milliseconds at baseline to 33.6 ± 20.7 milliseconds at 1 month (P = .001) and to 30.7 ± 19.4 milliseconds at 3 months (P < .001). Septal to posterior wall motion delay decreased from 90.3 ± 21.4 milliseconds to 83.9 ± 26.9 milliseconds (P = .011) at 1 month and to 81.5 ± 27.3 milliseconds at 3 months (P = .001). Septal to lateral Ts delay (Ts‐SL) decreased from 42.7 ± 24.5 milliseconds to 35.8 ± 22.6 milliseconds at 1 month (P < .001) and to 34.8 ± 22.4 milliseconds at 3 months (P = .002). Left ventricular end‐systolic volume (LVESV) decreased from 139.4 ± 42.2 mL to 135.3 ± 39.6 mL at 1 month (P = .006) and to 123.3 ± 39.5 mL at 3 months (P < .001).ConclusionThe addition of ivabradine to heart failure treatment improves cardiac dyssynchrony parameters in chronic systolic heart failure patients with sinus rhythm.
Association of chronic periodontitis with prostatic hyperplasia and prostatitis: A population‐based cohort study in Taiwan
Authors: Fu Earl , Cheng Chia‐Mao , Chung Chi‐Hsiang , Lee Wei‐Cheng , Chen Wei‐Liang , Sun Guang‐Huan , Chien Wu‐Chien 
Published: July 2020

AbstractBackgroundAssociation between periodontitis and prostate diseases of benign prostatic hyperplasia (BPH) and prostatitis is uncertain.MethodsFrom the National Health Insurance Research Database of Taiwan, 5,510 patients with newly diagnosed chronic periodontitis and participated in therapies were selected from 2000 to 2015 as cohort 1. Matched with age and index year, 5,510 patients with periodontitis diagnosis without therapy were selected as cohort 2, and 5,510 participants without diagnosis were used as control. Cox proportional hazard and survival analysis were performed to compare the risks and the survival probabilities among cohorts.ResultsIn two periodontitis cohorts, 636 and 638 participants compared with 550 in control (1,174 and 1,187 versus 989 per 100,000 person‐years) had prostate disorder. Difference was identified for prostatitis (n = 68, 70 versus 34; rate = 125, 130 versus 61 /100,000 person‐years; P <0.001) but not for BPH (n = 577, 575, versus 529; rate = 1,065, 1,070 versus 951 /100,000 person‐years, respectively). Different survival probabilities for prostate disorder and prostatitis, but not for BPH, were observed among cohorts. Periodontitis patients were more likely to develop prostate disorder after adjustment (adjusted hazard ratio [aHR] of 2.590 to 2.641 by competing model). With stratification, risks between two periodontitis cohorts exhibited no difference. When BPH cases were excluded, the aHRs for prostatitis were 4.611 to 4.798.ConclusionsDespite treatment, the patients with periodontitis had higher risk of developing prostatitis than patients without periodontitis.
Proteomic analysis of oilseed cake: a comparative study of species‐specific proteins and peptides extracted from ten seed species
Authors: Kotecka‐Majchrzak Klaudia , Sumara Agata , Fornal Emilia , Montowska Magdalena 
Published: July 2020

AbstractBackgroundIn recent years there has been a visible trend among consumers to move away from consuming meat in favor of plant products. Meat producers have therefore been trying to meet the expectations of consumers by introducing new products to the food market with a greater proportion of plant ingredients. Meat products are enriched not only by the addition of vegetable oils but also by ground or whole oilseeds or their preparation. In this study, we present in‐solution tryptic digestion and an ultra‐performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry (UHPLC‐Q‐TOF‐MS/MS)‐based proteomics approach to investigate specific proteins and peptides of ten oilseed cakes, by‐products of cold pressing oil from coconut, evening primrose, hemp, flax, milk thistle, nigella, pumpkin, rapeseed, sesame, and sunflower seeds, for authentication purposes.ResultsWe identified a total of 229 unique oilseed proteins. The number of specific proteins varied depending on the sample, from 4 to 48 in evening primrose and sesame. Moreover, we identified approximately 440 oilseed unique peptides in the cakes of all the analyzed oilseeds; the largest amounts were found in sesame (107 peptides), sunflower (100), pumpkin, hemp (42), rapeseed (36), and flax cake (35 peptides).ConclusionsWe provide novel information on unique / species‐specific peptide markers that will extend the scope of testing the authenticity of a wide range of foods. The results of this peptide discovery experiment may further contribute to the development of targeted methods for the detection and quantification of oilseed proteins in processed foods, and thus to the improvement of food quality. © 2020 Society of Chemical Industry
The influence of yak casein micelle size on rennet‐induced coagulation properties
Authors: Zhang Yan , Ren Fazheng , Wang Pengjie , Liang Qi , Peng Yun , Song Li , Wen Pengcheng 
Published: July 2020

AbstractBACKGROUNDYak milk formed stronger rennet‐induced gels if the milk contained smalled casein micelles and a higher concentration of calcium. Also casein gels could formed after a shorter incubation time if the milk contained smalled casein micelles. The objective of this study was to estimate the importance of yak casein micelle size on rennet‐induced coagulation properties.RESULTSThree fractions of different‐sized, undamaged casein micelles (Ф112.17 ± 0.83 nm, Ф207.13 ± 0.59 nm and Ф269.37 ± 2.89 nm) were obtained by ultracentrifugation. The smallest casein micelles had the highest concentrations of calcium (803.21 ± 8.49 mM), phosphate (445.52 ± 10.66 mM), and κ‐casein/total casein (19.45%). Rheological analyses determined the optimal gelation times of small, medium, and large casein micelles to be 9.5 ± 0.5, 10.8 ± 0.5, and 13.3 ± 0.2 min, respectively. Higher κ‐casein concentration in the small casein micelles appeared to facilitate their shorter incubation time. Both the faster caseinomacropeptide (CMP) release rate and rennet‐induced aggregation rate of small casein micelles contributed to a faster change in turbidity. Furthermore, small casein micelles had the highest elastic modulus (G′, 73.21 ± 4.5 Pa) 60 min after the addition of rennet. This was consistent with micro‐photographs, which showed that small casein micelles could form a more homogeneous gel, which had smaller pore sizes. Trial cheese manufacture verified that yak cheese containing small casein micelles, formed curd faster and the cheese had higher texture profile analysis (TPA) values for hardness, cohesiveness, and springiness.CONCLUSIONThis is important information for the optimization of yak cheese industrial production. © 2020 Society of Chemical Industry
Impact of surgical indication on patient outcomes and compliance with enhanced recovery program for colorectal surgery: A Francophone multicenter retrospective analysis
Authors: De Crignis Lucas , Slim Karem , Cotte Eddy , Meillat Hélène , Dupré Aurélien 
Published: July 2020

AbstractBackground and ObjectiveThe impact of surgical indication on compliance with enhanced recovery program (ERP) and on outcomes has never been assessed. This study aims to assess the impact of surgical indication (malignant vs benign) on postoperative outcomes and ERP compliance.MethodsA multicenter nationwide database was analyzed. Patients who underwent colorectal surgery for benign disease and those who underwent colorectal surgery for cancer were compared. Inclusion criteria were elective colorectal resection with anastomosis. ERP components, postoperative morbidity, and hospital length of hospital stay data were collected.ResultsAmong the 6472 patients registered in the database between October 2012 and June 2018, 4528 patients were included; 2647 in the malignant group and 1881 in the benign group. The ERP compliance over 70% was not different between groups. Postoperative morbidity rate was higher in the malignant group (22.5% vs 19.3%; P = .009) but not confirmed in multivariate analysis. Patients in the malignant group were more often readmitted after discharge, 6.6% vs 4.6% (P = .004). The mean LOS was 6.3 ± 5.0 days in the malignant group and 5.4 ± 4.7 days in the benign group (P < .001).ConclusionsIndication for colorectal surgery did not significantly influence peri‐operative management and postoperative major complications, in patients managed within an enhanced recovery program.