bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prehospital ultrasound use among Canadian aeromedical service providers – A cross-sectional survey
Authors: Sedlakova Anna , Olszynski Paul , Davis Philip , Froh John 
Published: December 2019

ABSTRACTObjectivesEvidence suggests that prehospital point of care ultrasound (POCUS) may change patient management. It serves as an aid in triage, physical examination, diagnosis, and patient disposition. The rate of adoption of POCUS among aeromedical services throughout Canada is unknown. The objective of this study was to describe current POCUS use among Canadian aeromedical services providers.MethodsThis is a cross-sectional observational study. A survey was emailed to directors of government-funded aeromedical services bases in Canada. Data were analyzed using descriptive statistics.ResultsThe response rate was 82.3% (14/17 aeromedical services directors), representing 41 of 46 individual bases. POCUS is used by aeromedical services in British Columbia, Alberta, Saskatchewan, and Manitoba. New Brunswick, Nova Scotia, Prince Edward Island, and Yukon reported they are planning to introduce POCUS within the next year. Ontario and Newfoundland reported they are not using POCUS and are not planning to introduce it. British Columbia is the only province currently using POCUS on fixed-wing aircraft. Most commonly reported frequency of POCUS use on missions was <25%. Most useful applications are assessment for pneumothorax, abdominal free fluid, and cardiac standstill. The most common barrier to POCUS use is cost of training and maintenance of competence.ConclusionsPrehospital POCUS is available in Western Canada with one third of the Canadian population having access to aeromedical services using ultrasound. The Maritimes and the Yukon Territory will further extend POCUS use on fixed-wing aircraft. While there are barriers to POCUS use, those bases that have adopted POCUS consider it valuable.
Stakeholder engagement in methodological research: Development of a clinical decision support tool
Authors: Daudelin Denise H. , Ruthazer Robin , Kwong Manlik , Lorenzana Rebecca C. , Hannon Daniel J. , Kent David M. , McAlindon Timothy E. , Terrin Norma , Wong John B. , Selker Harry P. 
Published: December 2019

AbstractIntroduction:Shared patient–clinician decision-making is central to choosing between medical treatments. Decision support tools can have an important role to play in these decisions. We developed a decision support tool for deciding between nonsurgical treatment and surgical total knee replacement for patients with severe knee osteoarthritis. The tool aims to provide likely outcomes of alternative treatments based on predictive models using patient-specific characteristics. To make those models relevant to patients with knee osteoarthritis and their clinicians, we involved patients, family members, patient advocates, clinicians, and researchers as stakeholders in creating the models.Methods:Stakeholders were recruited through local arthritis research, advocacy, and clinical organizations. After being provided with brief methodological education sessions, stakeholder views were solicited through quarterly patient or clinician stakeholder panel meetings and incorporated into all aspects of the project.Results:Participating in each aspect of the research from determining the outcomes of interest to providing input on the design of the user interface displaying outcome predications, 86% (12/14) of stakeholders remained engaged throughout the project. Stakeholder engagement ensured that the prediction models that form the basis of the Knee Osteoarthritis Mathematical Equipoise Tool and its user interface were relevant for patient–clinician shared decision-making.Conclusions:Methodological research has the opportunity to benefit from stakeholder engagement by ensuring that the perspectives of those most impacted by the results are involved in study design and conduct. While additional planning and investments in maintaining stakeholder knowledge and trust may be needed, they are offset by the valuable insights gained.
Athenacrinusn. gen. and other early echinoderm taxa inform crinoid origin and arm evolution
Authors: Guensburg Thomas E. , Sprinkle James , Mooi Rich , Lefebvre Bertrand , David Bruno , Roux Michel , Derstler Kraig 
Published: December 2019

AbstractIntermediate morphologies of a new fossil crinoid shed light on the pathway by which crinoids acquired their distinctive arms. Apomorphies originating deep in echinoderm history among early nonblastozoan pentaradiate echinoderms distinguish Tremadocian (earliest Ordovician) crinoid arms from later taxa. The brachial series is separated from the ambulacra, part of the axial skeleton, by lateral plate fields. Cover plates are arrayed in two tiers, and floor plates expressed podial basins and pores. Later during the Early Ordovician, floor plates contacted and nestled into brachials, then were unexpressed as stereom elements entirely and cover plates were reduced to a single tier. Incorporation of these events into a parsimony analysis supports crinoid origin deep in echinoderm history separate from blastozoans (eocrinoids, ‘cystoids’). Arm morphology is exceptionally well-preserved in the late Tremadocian to early FloianAthenacrinus browerinew genus new species. Character analysis supports a hypothesis that this taxon originated early within in the disparid clade.Athenacrinusn. gen. (in Athenacrinidae new family) is the earliest-known crinoid to express what is commonly referred to as ‘compound’ or ‘biradial’ morphology. This terminology is misleading in that no evidence for implied fusion or fission of radials exists, rather it is suggested that this condition arose through disproportionate growth.UUID:http://zoobank.org/b383e039-3298-4472-a7e3-e81684f87cfe
PREDICTING LANGUAGE PROFICIENCY IN BILINGUAL CHILDREN
Authors: De Cat Cécile 
Published: December 2019

AbstractUsing advanced quantitative methods, this article demonstrates that cumulative exposure to the school language is the best language experience predictor of proficiency in that language (as indexed by sentence repetition, lexical semantic, and discourse semantic tasks) in a highly diverse group of 5- to 7-year-old bilingual children in monolingual education. An objective method is proposed to identify the amount of school language experience beyond which bilingual children are likely to perform within the monolingual range, and show that relative passivity in the home language does not translate into better school language proficiency. Socioeconomic status is shown to interact in complex ways with language exposure, such that it is only above a certain level of exposure to the school language that the benefits of a more privileged background have a tangible impact on school language proficiency. To tease apart the effect of environmental predictors from the effect of cognitive factors, memory and cognitive flexibility measures are included as covariates in all analyses.
Acquiring a Beijing hukou: Who Is Eligible and Who Is Successful?
Authors: Liu Tao , Shi Qiujie 
Published: December 2019

AbstractUsing a localized perspective, this paper explores the gap between the eligibility criteria for a Beijing hukou (household registration) and the reality of successfully acquiring one. By comparing those who are eligible to apply with those who actually succeed in gaining a hukou, it reveals that hukou practices are operated locally to serve the city's development needs. It also reveals huge gaps between migrants, eligible applicants and hukou winners. Most migrants in Beijing are not eligible to apply for a local hukou. However, among those limited applicants who can apply, those with a postgraduate education and who serve the capital's political functions are more likely than others to win a hukou, an advantage not pointed out in government documents. These “hidden” rules are most likely set intentionally by the city so that it can maintain absolute control over hukou transfers; however, at the same time, they frustrate migrants who meet the stated requirements but who are in reality still unlikely to ever acquire a Beijing hukou. These findings open up a novel perspective for exploring the people–city nexus in China during the migration process and highlight the gaps between policy and reality for those who can apply for a Beijing hukou and those who actually win one.
Monolinguals and bilinguals respond differently to a delayed matching-to-sample task: An ERP study
Authors: Morrison Cassandra , Kamal Farooq , Le Kim , Taler Vanessa 
Published: December 2019

AbstractPrevious research examining whether bilinguals exhibit enhanced working memory (WM) compared to monolinguals has yielded mixed results. This inconsistency may be due to lack of sensitivity in behavioral and neuropsychological measures. The current study aimed to investigate the effects of bilingualism on WM by focusing on brain activity patterns (event-related potentials) in monolinguals and bilinguals during a WM task. We recorded brain activity while participants (26 monolingual English speakers and 28 English–French bilinguals) performed a delayed matching-to-sample task. Although performance measures were similar, electrophysiological differences were present across groups. Bilinguals exhibited larger P3b amplitudes than monolinguals, and smaller negative slow wave and N2b amplitudes during retrieval. These results suggest that bilinguals may have more cognitive resources available in WM to allocate to task completion, and that task completion may be less effortful for bilinguals than for monolinguals.
Food insecurity and weight status of socially vulnerable child beneficiaries of a food assistance programme in Maceió, Northeast Brazil
Authors: Lucena Priscila Nazaré , Bueno Nassib Bezerra , Vieira Karlla Almeida , Cabral Marcela Jardim , Clemente Ana Paulo Grotti , Florêncio Telma Maria de Menezes Toledo 
Published: December 2019

AbstractObjective:To evaluate the association between weight status and food insecurity of children living in social vulnerability who are beneficiaries of a food assistance programme (FAP).Design:Cross-sectional study.Setting:From all children benefiting from the FAP in the municipality, 30 % were mapped in forty-seven distribution points. Their weight status was evaluated using BMI-for-age and food insecurity was determined with the Brazilian Food Insecurity Scale. Socio-economic data of the participants were collected using regular questionnaires. The main outcome measure was obesity.Participants:To be a beneficiary of the FAP, a family must have a child aged 24–96 months and receive less than half a minimum wage per capita. Participating families receive 1 litre of whole milk per day.Results:In all, 1487 children had BMI-for-age and food insecurity data. Of these children, 376 (25·3 %) had excess weight, of whom 164 (11·0 %) presented with obesity, and only twenty-seven (1·8 %) were underweight; 76 % of the families had some degree of food insecurity. Multivariable analysis revealed no overall association between household food insecurity and weight status. In the specific comparison, children living in severe food insecurity were less likely to present obesity than those children living in food security (prevalence ratio = 0·60; 95 % CI 0·38, 0·96; P = 0·03).Conclusions:In a socially vulnerable population that participates in a FAP, there was no overall association between food insecurity and weight status in children, a result which is similar to what is observed in more developed contexts.
SOME MODEL-THEORETIC RESULTS ON THE 3-VALUED PARACONSISTENT FIRST-ORDER LOGIC QCIORE
Authors: CONIGLIO MARCELO E. , GOMEZ-PEREIRA G.T. , FIGALLO MARTÍN 
Published: December 2019

AbstractThe 3-valued paraconsistent logic Ciore was developed by Carnielli, Marcos and de Amo under the name LFI2, in the study of inconsistent databases from the point of view of logics of formal inconsistency (LFIs). They also considered a first-order version of Ciore called LFI2*. The logic Ciore enjoys extreme features concerning propagation and retropropagation of the consistency operator: a formula is consistent if and only if some of its subformulas is consistent. In addition, Ciore is algebraizable in the sense of Blok and Pigozzi. On the other hand, the logic LFI2* satisfies a somewhat counter-intuitive property: the universal and the existential quantifier are inter-definable by means of the paraconsistent negation, as it happens in classical first-order logic with respect to the classical negation. This feature seems to be unnatural, given that both quantifiers have the classical meaning in LFI2*, and that this logic does not satisfy the De Morgan laws with respect to its paraconsistent negation. The first goal of the present article is to introduce a first-order version of Ciore (which we call QCiore) preserving the spirit of Ciore, that is, without introducing unexpected relationships between the quantifiers. The second goal of the article is to adapt to QCiore the partial structures semantics for the first-order paraconsistent logic LPT1 introduced by Coniglio and Silvestrini, which generalizes the semantic notion of quasi-truth considered by Mikeberg, da Costa and Chuaqui. Finally, some important results of classical Model Theory are obtained for this logic, such as Robinson’s joint consistency theorem, amalgamation and interpolation. Although we focus on QCiore, this framework can be adapted to other 3-valued first-order LFIs.
Sensitivity of dry edible bean to dicamba and 2,4-D
Authors: Bales Scott R. , Sprague Christy L. 
Published: December 2019

AbstractDicamba and 2,4-D exposure to sensitive crops, such as dry bean, is of great concern with the recent registrations of dicamba- and 2,4-D–resistant soybean. In 2017 and 2018, field experiments were conducted at two Michigan locations to understand how multiple factors, including dry bean market class, herbicide rate, and application timing, influence dry bean response to dicamba and 2,4-D. Dicamba and 2,4-D at rates of 0.1%, 1%, and 10% of the field use rate for dicamba and 2,4-D choline were applied to V2 and V8 black and navy bean. Field-use rates for dicamba and 2,4-D choline were 560 and 1,120 g ae ha−1, respectively. There were few differences between market classes or application timings when dry bean was exposed to dicamba or 2,4-D. Estimated rates to cause 20% dry bean injury 14 d after treatment were 4.5 and 107.5 g ae ha−1 for dicamba and 2,4-D, respectively. When dicamba was applied at 56 g ae ha−1, light interception was reduced up to 51% and maturity was delayed up to 16 d. Although both herbicides caused high levels of injury to dry bean, yield reductions were not consistently observed. At four site-years, 2,4-D did not reduce dry bean yield or seed weight with any rate tested. However, when averaged over site-years, dicamba rates of 3.7, 9.8 and 17.9 g ae ha−1 were estimated to cause 5%, 10%, and 15% yield loss, respectively. Dicamba also reduced seed weight by 10% when 56 g ae ha−1 was applied. However, the germination of harvested seed was not affected by dicamba or 2,4-D. Long delays in dry bean maturity from dicamba injury can also indirectly increase losses in yield and quality due to harvestability issues. This work further stresses the need for caution when using dicamba or 2,4-D herbicides near sensitive crops.
Morning Overshoot of Electron Temperature as Observed by the Swarm Constellation and the International Space Station
Authors: Yang Tae‐Yong , Park Jaeheung , Kwak Young‐Sil , Oyama Koh‐Ichiro , Minow Joseph I. , Lee Jaejin 
Published: December 2019

AbstractThe rapid increase of electron temperature in the early morning hours at low latitudes is a well‐known ionospheric phenomenon called morning overshoot. In this study, we extensively investigate the dependence of morning overshoot on local time, season, latitude/longitude/altitude, and magnetic activity. The electron temperature and density data set used in this study are obtained from (1) the Swarm constellation at two different altitudes of 470 and 520 km with identical payloads and (2) the Floating Potential Measurement Unit onboard International Space Station at an altitude of 400 km. Based on the data between 2014 and 2019, the main findings of this study are as follows: (1) on a global average, morning overshoot generally weakens with decreasing altitudes. (2) Morning overshoot is stronger around the dip equator than at midlatitude regions. As latitude increases, the overshoot decreases gradually and shifts to later local times. (3) In off‐equatorial regions the overshoot is stronger in the winter than in the summer hemisphere, especially at higher altitudes. (4) Lastly, the morning overshoot shows multiday oscillations, which are negatively correlated with plasma density and affected by geomagnetic activity.
Low prevalence of clinical decision support to calculate caloric and fluid intake for infants in the neonatal intensive care unit
Authors: Falciglia Gustave H. , Murthy Karna , Holl Jane L. , Palac Hannah L. , Woods Donna M. , Robinson Daniel T. 
Published: December 2019

AbstractBackgroundClinical decision support (CDS) improves nutrition delivery for infants in the neonatal intensive care unit (NICU), however, the prevalence of CDS to support nutrition is unknown.MethodsOnline surveys, with telephone and email validation of responses, were administered to NICU clinicians in the Children’s Hospital Neonatal Consortium (CHNC). We determined and compared the availability of CDS to calculate calories and fluid received in the prior 24 h, stratified by enteral and parenteral intake, using McNemar’s test.ResultsClinicians at all 34 CHNC hospitals responded with 98 of 108 (91%) surveys completed. NICUs have considerably less CDS to calculate enteral calories received than enteral fluid received (32% vs. 82%,p < 0.001) and less CDS to calculate parenteral calories received than parenteral fluid received (29% vs. 82%,p < 0.001).DiscussionMost CHNC NICUs are unable to reliably and consistently monitor caloric intake delivered to critically ill infants at risk for growth failure.
Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells
Authors: Djeungoue-Petga Marie-Ange , Lurette Olivier , Jean Stéphanie , Hamel-Côté Geneviève , Martín-Jiménez Rebeca , Bou Marine , Cannich Astrid , Roy Patrick , Hebert-Chatelain Etienne 
Published: December 2019

AbstractHigh levels and activity of Src kinase are common among breast cancer subtypes, and several inhibitors of the kinase are currently tested in clinical trials. Alterations in mitochondrial activity is also observed among the different types of breast cancer. Src kinase is localized in several subcellular compartments, including mitochondria where it targets several proteins to modulate the activity of the organelle. Although the subcellular localization of other oncogenes modulates the potency of known treatments, nothing is known about the specific role of intra-mitochondrial Src (mtSrc) in breast cancer. The aim of this work was to determine whether mtSrc kinase has specific impact on breast cancer cells. We first observed that activity of mtSrc is higher in breast cancer cells of the triple negative subtype. Over-expression of Src specifically targeted to mitochondria reduced mtDNA levels, mitochondrial membrane potential and cellular respiration. These alterations of mitochondrial functions led to lower cellular viability, shorter cell cycle and increased invasive capacity. Proteomic analyses revealed that mtSrc targets the mitochondrial single-stranded DNA-binding protein, a regulator of mtDNA replication. Our findings suggest that mtSrc promotes aggressiveness of breast cancer cells via phosphorylation of mitochondrial single-stranded DNA-binding protein leading to reduced mtDNA levels and mitochondrial activity. This study highlights the importance of considering the subcellular localization of Src kinase in the development of potent therapy for breast cancer.
Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway
Authors: Kung-Chun Chiu David , Pui-Wah Tse Aki , Law Cheuk-Ting , Ming-Jing Xu Iris , Lee Derek , Chen Mengnuo , Kit-Ho Lai Robin , Wai-Hin Yuen Vincent , Wing-Sum Cheu Jacinth , Wai-Hung Ho Daniel , Wong Chun-Ming , Zhang Huafeng , Ng Irene Oi-Lin , Chak-Lui Wong Carmen 
Published: December 2019

AbstractHypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O2) as the electron recipient, causes inefficient electron transfer through the electron transport chain at the mitochondria leading to accumulation of reactive oxygen species (ROS) which could create irreversible cellular damages. Through hypoxia-inducible factor 1 (HIF-1) which elicits various molecular events, cells are able to overcome low O2. Knowledge about the new molecular mechanisms governed by HIF-1 is important for new therapeutic interventions targeting hypoxic tumors. Using hepatocellular carcinoma (HCC) as a model, we revealed that the HIF-1 and the Notch signaling pathways cross-talk to control mitochondrial biogenesis of cancer cells to maintain REDOX balance. From transcriptome sequencing, we found that HEY1, a transcriptional repressor, in the NOTCH pathway was consistently induced by hypoxia in HCC cell lines. We identified a strong hypoxia response element (HRE) in HEY1 by chromatin immunoprecipitation (ChIP) and luciferase reporter assays. Transcriptome and ChIP sequencing further identified PINK1, a gene essential for mitochondrial biogenesis, as a novel transcriptional target of HEY1. HCC cells with HEY1 knockdown re-expressed PINK1. HEY1 and PINK1 expressions inversely correlated in human HCC samples. Overexpression of HEY1 and under-expression of PINK1 were detected in human HCC and associated with poor clinical outcomes. Functionally, we found that overexpression of HEY1 or knockdown of PINK1 consistently reduced mitochondrial cristae, mitochondrial mass, oxidative stress level, and increased HCC growth.
Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3
Authors: Huang Zixian , Zhang Yin , Li Haigang , Zhou Yufeng , Zhang Qianyu , Chen Rui , Jin Tingting , Hu Kaishun , Li Shihao , Wang Yan , Chen Weiliang , Huang Zhiquan 
Published: December 2019

AbstractChemoresistance is a major cause of cancer progression and the mortality of cancer patients. Developing a safe strategy for enhancing chemosensitivity is a challenge for biomedical science. Recent studies have suggested that vitamin D supplementation may decrease the risk of many cancers. However, the role of vitamin D in chemotherapy remains unknown. We found that vitamin D sensitised oral cancer cells to cisplatin and partially reversed cisplatin resistance. Using RNA-seq, we discovered that lipocalin 2 (LCN2) is an important mediator. Cisplatin enhanced the expression of LCN2 by decreasing methylation at the promoter, whereas vitamin D enhanced methylation and thereby inhibited the expression of LCN2. Overexpression of LCN2 increased cell survival and cisplatin resistance both in vitro and in vivo. High LCN2 expression was positively associated with differentiation, lymph node metastasis, and T staging and predicted a poor prognosis in oral squamous cell carcinoma (OSCC) patients. LCN2 was also associated with post-chemotherapy recurrence. Moreover, we found that LCN2 promoted the activation of NF-κB by binding to ribosomal protein S3 (RPS3) and enhanced the interaction between RPS3 and p65. Our study reveals that vitamin D can enhance cisplatin chemotherapy and suggests that vitamin D should be supplied during chemotherapy; however, more follow-up clinical studies are needed.