bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study
Authors: Ness Nils-Henning , Haase Rocco , Kern Raimar , Schriefer Dirk , Ettle Benjamin , Cornelissen Christian , Akguen Katja , Ziemssen Tjalf 
Published: February 2020

Background
Survey-based studies are frequently used to describe the economic impact of multiple sclerosis (MS). However, there is no validated health resource survey available, preventing comparison of study results and meaningful conclusions regarding the efficiency of long-term treatments.

Objective
The aim of this study was to develop and validate a tablet- and paper-based MS health resource utilization survey.

Methods
We developed and validated the Multiple Sclerosis Health Resource Utilization Survey (MS-HRS), consisting of 24 cost items for paper and tablet users. Data for validation came from two large German observational studies. Survey practicability was assessed according to the response rate. Reliability was described using test-retest reliability as well as Guttman lambda. Construct validity was assessed as convergent and discriminant validity via correlations with associated patient-reported outcomes and known-group analyses.

Results
In total, 2207 out of 2388 (response rate: 92.4%) patients completed the survey and were included to determine psychometric properties. The test-retest reliability had an intraclass correlation coefficient of 0.828 over a course of 3 months. Convergent validity analyses showed that total costs correlated positively with increased disability (r=0.411, P<.001). For discriminant validity, correlations of total costs with the Treatment Satisfaction Questionnaire for Medication ranged from −0.006 (convenience) to −0.216 (effectiveness). The mean annual cost was €28,203 (SD €14,808) (US $39,203; SD US $20,583) with disease-modifying therapies.

Conclusions
The MS-HRS is a multilingual, reliable, valid, electronically available, and easy-to-administer questionnaire providing a holistic cross-sectional and longitudinal assessment of resource utilization in patients with MS.
Alguns conceitos da sociologia de Pierre Bourdieu relacionados com a análise de rede social
Authors: Alves Bruno Henrique , Oliveira Ely Francina Tannuri 
Published: February 2020

O Campo da Ciência da Informação - CI é um espaço hierarquizado, relativamente autônomo e formado por relações objetivas que se dão em um contexto social. Esta pesquisa objetiva compreender os mecanismos implícitos à geração e construção do conhecimento dos pesquisadores bolsistas de produtividade em pesquisa do CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico - em CI e a posição social que ocupam no Campo em questão. De forma mais específica, pretende: compreender os mecanismos sociais construídos para organizar e facilitar aestruturação das redes de colaboração científica dos pesquisadores bolsistas de produtividade em pesquisa do CNPq em CI;e fundamentar a Análise de Redes Sociais – ARS, a partir da teoria do Campo e os conceitos de Capital Social e Capital Científico, propostos pela Sociologia de Pierre Bourdieu. Para a construção das redes de colaboração científica entre os pesquisadores, utilizou-se o Software Ucinet. A teoria do Campo Científico foi utilizada também para complementar o procedimento de Análise de Redes Sociais, com foco na caracterização e evolução das redes de colaboração científica (2005-2009 e 2010-2014). Como conclusões, destaca-se que, de acordo com os fundamentos da Sociologia de Pierre Bourdieu, para ocupar uma posição de dominante, o pesquisador bolsista de produtividade em pesquisa doCNPqdeve entender a lógica do jogo, pois o Campo possui eixos estruturantes a partir dois quais se identificam os principais jogadores que ocupam esse espaço social de concorrência científica.
Acesso Aberto em questão: novas agendas e desafios
Authors: Luiz Appel André , Albagli Sarita 
Published: February 2020

Passados quase 20 anos desde a Declaração de Budapeste (2002) e frente a recorrentes controvérsias em torno dos periódicos científicos, cabe indagar em que medida a crise dos periódicos ganha novos contornos e assume novas dimensões, e como vem repercutindo nos modos de se fazer ciência. O objetivo deste trabalho é problematizar os aspectos que configuram a crise dos periódicos científicos e seus desdobramentos recentes, sistematizando os argumentos sobre as principais questões e desafios atuais nessa questão, bem como caracterizando a emergência de um novo ecossistema de comunicação científica em torno do desenvolvimento de novas plataformas e infraestruturas de publicação. A abordagem metodológica do estudo envolveu: (a) revisão da literatura a partir de uma perspectiva crítica; (b) realização de entrevistas com especialistas e advocates; e (c) levantamento e discussão sobre iniciativas emergentes e inovadoras nesse campo. Como resultados, apontamos o potencial de ampliação da variedade de objetos científicos em circulação, ampliando suas condições de interoperabilidade, de conformação de infraestruturas abertas e governanças comunitárias, até processos mais críticos como a conversão do acesso aberto em modelo de negócio e a verticalização e algoritmização da oferta de serviços à pesquisa científica.
Palavras-chave: Comunicação científica. Acesso aberto. Ciência aberta. Periódicos científicos. Plataformas.
Change in the use of remote monitoring of cardiac implantable electronic devices in Italian clinical practice over a 5-year period: results of two surveys promoted by the AIAC (Italian Association of Arrhythmology and Cardiac Pacing)
Authors: Palmisano Pietro , Melissano Donato , Zanotto Gabriele , Perego Giovanni Battista , Toselli Tiziano , Landolina Maurizio , Ricci Renato Pietro 
Published: February 2020

Aims
The aim of this study was to evaluate the use of remote monitoring in Italian clinical practice and its trend over the last 5 years.

Methods
In 2012 and 2017, two surveys were conducted. Both were open to all Italian implanting centres and consisted of 25 questions on the characteristics of the centre, their actual use of remote monitoring, applied organizational models and administrative and legal aspects.

Results
The questionnaires were completed by 132 and 108 centres in 2012 and 2017, respectively (30.6 and 24.7% of all Italian implanting centres). In 2017, significantly fewer centres followed up fewer than 200 patients by remote monitoring than in 2012, while more followed up more than 500 patients (all P < 0.005). In most of the centres (77.6%) that responded to both surveys, the number of patients remotely monitored significantly increased from 2012 to 2017.
In both surveys, remote monitoring was usually managed by physicians and nurses. Over the period, primary review of transmissions by physicians declined, while it was increasingly performed by nurses; the involvement of technicians rose, while that of manufacturers’ technical personnel decreased. The percentage of centres in which transmissions were submitted to the physician only in critical cases rose (from 28.3 to 64.3%; P < 0.001). In 86.7% of centres, the lack of a reimbursement system was deemed the main barrier to implementing remote monitoring.

Conclusion
In the last 5 years, the number of patients followed up by remote monitoring has increased markedly. In most Italian centres, remote monitoring has increasingly been managed through a primary nursing model. The lack of a specific reimbursement system is perceived as the main barrier to implementing remote monitoring .
Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway
Authors: Wang Naizhi , Feng Tao , Liu Xiaona , Liu Qin 
Published: February 2020

Abstract
Curcumin has been proved to inhibit cell proliferation and induce cell apoptosis in non-small cell lung cancer (NSCLC). However, little is known about antimetastatic effects and molecular mechanisms of curcumin in NSCLC. In this study, we investigated the involvement of miR-206 in curcumin’s anti-invasion and anti-migration in NSCLC. Cell proliferation was determined by MTT assay. Cell migration and invasion were analyzed by wound healing assay and transwell assay. MiRNA-206 expression was detected by real-time PCR. Western blot was used to detect the protein expression of PI3K/AKT/mTOR signaling pathway. Curcumin significantly inhibited migration and invasion in A549 cells, accompanied by significantly elevated miR-206 expression. Overexpression of miR-206 could inhibit migration and invasion of A549 cells, but it could also significantly decrease the phosphorylation levels of mTOR and AKT. The inhibition of miR-206 promoted cell migration, invasion and increased the phosphorylation level of mTOR and AKT. Furthermore, miR-206 mimics improved the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT in A549 cells. On the contrary, MiR-206 inhibitors reversed the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT. In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway.
Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride
Authors: Gu Fugen , Fan Huimin , Cong Zhixin , Li Shuang , Wang Yi , Wu Chunzhi 
Published: February 2020

Abstract
Donepezil hydrochloride thermosensitive in situ gel for nasal delivery was prepared by using Poloxamer 407 and Poloxamer 188 as thermoreversible polymers, hydroxypropyl-β-cyclodextrin and ethylparaben as permeation enhancer and preservative, respectively. The gelation temperature and time, pH value of the gel formulation were found to meet the requirements for nasal administration. The in vitro erosion and in vitro release tests exhibited obvious drug sustained release behavior. Meantime, main pharmacokinetic parameters such as t
max, c
max and AUC in plasma as well as in brain were significantly different between the nasal gel formulation and intragastric drug solution in rats (p < 0.01). The relative bioavailability and drug targeting efficiency of the gel formulation were calculated to be 385.6 and 151.2 %, respectively. Thus, the drug gel formulation might be a potential new delivery system for treatment of Alzheimer’s disease due to its higher bioavailability and better distribution to brain when compared to oral route.
Optimization of Protein Feed Fermentation Process for Supplementation of Apis Mellifera Honeybees
Authors: Lima Erica G. , Parpinelli Rejane S. , Santos Pedro R. , Azevedo Alexandre S. B. , Sereia Maria J. , Arnaut de Toledo Vagner A. 
Published: February 2020

Abstract
An alternative to natural food shortage for honeybees is the provision of supplements. The objective of this research was to develop a method with ideal conditions for the fermentation of a protein supplement for honeybees. The microorganisms used were Lactobacilli, Bifidobacteria and Saccharomyces and the inulin prebiotic. There was an increase in lactic acid and a decrease in pH over a five-day fermentation period. The amount of acid bacteria present was 108–109 CFU/g of supplement. In the first phase the temperature and the humidity had significantly affected the fermentation but the variables inulin and probiotic didn’t. In the second phase, the lower temperatures and higher humidity produced the best effects on the fermentative responses. It was concluded that an ideal environment with temperature, humidity, inulin and probiotics could be created which allowed the fermentation of the protein supplement in five days obtaining final product fermentative characteristics close to bee bread.
Socioeconomic inequalities in cancer incidence in Europe: a comprehensive review of population-based epidemiological studies
Authors: Mihor Ana , Tomsic Sonja , Zagar Tina , Lokar Katarina , Zadnik Vesna 
Published: February 2020

Abstract

Background
Since the end of the previous century, there has not been a comprehensive review of European studies on socioeconomic inequality in cancer incidence. In view of recent advances in data source linkage and analytical methods, we aimed to update the knowledge base on associations between location-specific cancer incidence and individual or area-level measures of socio-economic status (SES) among European adults.

Materials and methods
We systematically searched three databases (PubMed, Scopus and Web of Science) for articles on cancer incidence and SES. Qualitative synthesis was performed on the 91 included English language studies, published between 2000 and 2019 in Europe, which focused on adults, relied on cancer registry data and reported on relative risk (RR) estimates.

Results
Adults with low SES have increased risk of head and neck, oesophagogastric, liver and gallbladder, pancreatic, lung, kidney, bladder, penile and cervical cancers (highest RRs for lung, head and neck, stomach and cervix). Conversely, high SES is linked with increased risk of thyroid, breast, prostate and skin cancers. Central nervous system and haematological cancers are not associated with SES. The positive gap in testicular cancer has narrowed, while colorectal cancer shows a varying pattern in different countries. Negative associations are generally stronger for men compared to women.

Conclusions
In Europe, cancers in almost all common locations are associated with SES and the inequalities can be explained to a varying degree by known life-style related factors, most notably smoking. Independent effects of many individual and area SES measures which capture different aspects of SES can also be observed.
Long term response of electrochemotherapy with reduced dose of bleomycin in elderly patients with head and neck non-melanoma skin cancer
Authors: Jamsek Crt , Sersa Gregor , Bosnjak Masa , Groselj Ales 
Published: February 2020

Abstract

Background
Electrochemotherapy (ECT) is a local cancer treatment based on electroporation where the electric field is used to enhance cell membrane permeability and thereby facilitating the transition of chemotherapeutic agents into the cell. For the treatment of non-melanoma skin cancer, a standard dosage of 15,000 IU/m2 bleomycin (BLM) is used. The aim of the present study was to evaluate the long-term ECT response in the group of elderly patients with non-melanoma skin cancer treated with a reduced dose of BLM in comparison to the outcome in the patients treated with the standard dose of BLM.

Patients and methods
Twenty-eight patients older than 65 years, with a total of 52 non-melanoma skin lesions were included in the study. Twelve patients (24 lesions) in the experimental group received a reduced dose of BLM (10,000 IU/m2), 16 patients (28 lesions) were treated with a standard dose of BLM (15,000 IU/m2).

Results
No statistically significant difference in tumor control was observed between both groups. In the experimental group, tumors recurred in 39.0% of treated lesions in a median follow-up time of 28 months. In the control group, the recurrence rate of treated lesions was 15.4% in a median follow-up time of 40 months.

Conclusions
ECT with a reduced dose of BLM is a feasible treatment option for elderly patients with equal efficacy to standard dose treatment and should be considered as a treatment modality in advanced aged patients with comorbidities, where overall life expectancy is poor.
Machine Learning-Based Distributed Denial of Service Attack Detection on Intrusion Detection System Regarding to Feature Selection
Authors: Azhari Ahmad , Muhammad Arif Wirawan , Foozy Cik Feresa Mohd 
Published: February 2020

Distributed Service Denial (DDoS) is a type of network attack, which each year increases in volume and intensity. DDoS attacks also form part of the major types of cyber security threats so far. Early detection plays a key role in avoiding the catastrophic effects on server infrastructure from DDoS attacks. Detection techniques in the traditional Intrusion Detection System (IDS) are far from perfect compared to a number of modern techniques and tools used by attackers, because the traditional IDS only uses signature-based detection or anomaly-based detection models and causes a lot of false positive flags, since the flow of computer network data packets has complex properties in terms of both size and source. Based on the deficiency in the ordinary IDS, this study aims to detect DDoS attacks by using machine learning techniques to enhance IDS policy development. According to the experiment the selection of features plays an important role in the precision of the detection results and in the performance of machine learning in classification problems. The combination of seven key selected dataset features used as an input neural network classifier in this study provides the highest accuracy value at 97.76%.
Kajian Jembatan Kecamatan Sendang (Ruas Jalan Tugu-Pabyongan) Kabupaten Tulungagung dengan Metode Komposit
Authors: Purnomo Tri Yuli , Krisnawati Lucia Desti , Purnomo Yosef Cahyo Setianto 
Published: February 2020

Pertumbuhan penduduk di Kabupaten Tulungagung yang semakin pesat harus diimbangi dengan sarana prasarana transportasi yang memadai. Peningkatan sarana dan prasarana transportasi ini berupa pembangunan jembatan. Jembatan merupakan salah satu akses yang menghubungkan antara daerah yang satu dengan daerah lainnya yang terpisah karena keadaan alam, misalnya adanya lembah, jurang, sungai maupun rel kereta api. Dalam merencanakan kontruksi jembatan, selain menyesuaikan dengan perkembangan lalu lintas dan tonase kendaraan yang lewat juga harus mempertimbangkan keadaan dan lokasi di mana jembatan itu akan dibangun. Namun tidak berarti jembatan harus dibuat lebih kuat dan tidak memperhatikan faktor ekonomisnya. Mengingat faktor ekonomis dan kekuatan dari kontruksi jembatan tersebut, maka dalam perencanaan jembatan diusahakan menghasilkan kontruksi yang dapat menjamin kekuatannya dan paling ekonomis ditinjau dari segi biaya pembangunan maupun pelaksanaannya.Jembatan Sendang (Ruas Jalan Tugu – Pabyongan)dengan bentang 36 meter ( 3 x 12m ) dengan lebar 7 meter merupakan proyek Dinas PU Bina Marga dan Cipta Karya Kabupaten Tulungagung, Anggaran Pendapatan dan Belanja Daerah (APBD) Tahun 2016. Jembatan tersebut menghubungkan Kecamatan Sendang sebagai kawasan wisata dan agropolitan penghasil sayur-sayuran terbesar se Kabupaten Tulungagung. Jembatan Sendang memudahkan distribusi buah dan sayur ke seluruh wilayah karisidenan Kediri khususnya Kabupaten Tulungagung. Jembatan Sendang tersebut berada di atas sungai Song yang memiliki debit air sedang dan membesar ketika hujan.Daerah Sendang terletak di kaki gunung Wilis dimana akan dibangun Proyek Lingkar Wilis oleh Pemprov Jawa Timur yang menghubungkan Wilayah Trenggalek, Kediri, Tulungagung, danj Ponorogo. Jembatan Kecamatan Sendang (Ruas Jalan Tugu Pabyongan) ini merupakan jembatan yang akan dilewati oleh proyek tersebut, sehingga studi jembatan ini sangat diperlukan untuk menunjang pembangunan tersebut.Kata kunci : Jembatan, Komposit, Struktur atas
PERENCANAAN STRUKTUR BAJA PADA KONSTRUKSI EMPAT LANTAI PADA HOTEL JAYA BAYA
Authors: Saputra Alfin Aziz , Winarto Sigit , Ridwan Ahmad 
Published: February 2020

AbstractConstruction buildings in Kediri area still tends to use concrete construction with conventional methods, which are prone to specifications from planning the structure of the building. Due the process of making cast dough and casting it is often not done properly so it can eliminate the strength and structure. Therefore, hotel building is planned to use Steel Construction and Precast Floor Elimination, in order to have not reduction in specification design structure.In LRFD method, probability analysis is not needed, except for general situations not set in Regulations Obtained LRFD planning calculations referring to the latest SNI 1729-2015.Based on the planning, the calculation structure of loading is calculated in m2, where the production results are entered into the Sap 2000 v20 analysis software program. The structure used on PL 125 floor panels. 2000, beam WF 300x150x6.5x9, column WF 400x400z13x21, the conclusion of the structure is safe based on the applicable conditions. Keywords : steel structure planning for SNI building 03-1729-2015
ANALISIS KEMAMPUAN PEMECAHAN MASALAH DITINJAU DARI MOTIVASI BELAJAR MATEMATIKA SISWA
Authors: Rigusti Wangsit , Pujiastuti Heni 
Published: February 2020

Penelitian ini bertujuan untuk mendeskripsikan kemampuan pemecahan masalah ditinjau dari motivasi belajar matematika siswa. Penelitian ini merupakan jenis penelitian deskriptif kuantitatif. Pokok bahasan dalam penelitian ini adalah statistika. Subjek dalam penelitian ini adalah siswa kelas XII IPS 1 SMA Negeri 17 Pandeglang tahun ajaran 2019/2020 yang berjumlah 32 siswa. Instrumen pengumpulan data yang digunakan antara lain soal test akhir untuk melihat kemampuan pemecahan masalah siswa dan lembar angket motivasi belajar siswa. Teknik analisis data dalam penelitian ini menggunakan persentase skor dan anova dua jalur. kemampuan pemecahan masalah dan motivasi belajar matematika siswa dilihat dari kategori tinggi, sedang, dan rendah. Berdasarkan hasil pengolahan data, bahwa sebaran motivasi belajar tinggi 25 % siswa, motivasi belajar sedang 47 % siswa, dan motivasi rendah 28 % siswa. Dengan skor ideal 100, diperoleh rata- rata kemampuan pemecahan masalah matematika secara keseluruhan yaitu sebesar 68,75. Rata-rata kemampuan pemecahan masalah siswa yang memiliki motivasi tinggi yaitu 75.6, Siswa dengan motivasi sedang rata-rata kemampuan pemecahan masalah matematika 70.7, dan rata-rata kemampuan pemecahan masalah untuk siswa dengan motivasi rendah yaitu 59,4. Hasil analisis dengan uji anova dua jalur bahwa terdapat perbedaan kemampuan pemecahan masalah matematika siswa antara motivasi belajar tinggi, sedang, dan rendah.
Analisis dan Perancangan Desain Sistem Informasi Pembayaran Tagihan Supplier Pada PT. Jaya Teknik Indonesia Berdasarkan Kebutuhan Sistem
Authors: Hariyadi Tri , Laraswati Dewi , Ariani Fattya 
Published: February 2020

Abstract - Economic development in Indonesia is currently growing rapidly. To achieve this economic development, a good system is needed. One of these systems is a payment system. That is a system that deals with payments made by a company to suppliers so that a job can be completed on time without any financial disturbances. An integrated system makes it easy for employees to do their work. PT Jaya Teknik Indonesia is a contracting company. The existing system of PT Jaya Teknik Indonesia is currently not computerized. The manual process for checking the billing file causes the length of the payment process due to the large number of billing files that have to be processed and not connected between one part and another so that to conduct a complete data check must ask directly the relevant part. Because of this, the author tries to make the bill payment system of suppliers at PT Jaya Teknik Indonesia. This payment system analysis is made to solve the problems that exist in this company in order to achieve an effective and efficient system in carrying out activities in the company.
Keywords: System Design, Payment Information System Design, Payment Information System, Bill Payment Information System