bluuebunny/crossref_metadata_2025_split huggingface dataset:
AS RELAÇÕES ENTRE OS ARTESÃOS FILIGRANEIROS DE NATIVIDADE, TOCANTINS E O TURISMO
Authors: Fernandes Bonfim Wátila , Balsan Rosane 
Published: March 2020

A cidade de Natividade fica no Tocantins, sendo a primeira localidade tombada pelo Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN) no Estado. Um traço que codifica a cidade, considerada um patrimônio cultural imaterial por seus moradores é a secular fabricação de joias utilizando a técnica da filigrana, que consiste em curvar e trançar fios de ouro ou prata, formando grãos. No que diz respeito ao turismo, ficou descortinada a tendência a visitação às ourivesarias por parte de visitantes que valorizam o turismo cultural. Tal fato mobiliza a economia da cidade e atrai dividendos. O objetivo principal deste trabalho foi investigar como a as joias tradicionais e/ou filigranadas de Natividade marcam a relação da sociedade com o lugar, dinamizando as relações sociais e econômicas das pessoas. A pesquisa está inserida na perspectiva da geografia cultural e teve como principais conceitos abordados: patrimônio, identidade, turismo e o lugar. No que se refere à metodologia, a pesquisa foi realizada através da abordagem qualitativa bola de neve. No total, entrevistou-se 44 pessoas, entre ourives, ex-ourives, aprendizes, moradores e sujeitos ligados ao turismo local. Fez-se uso também da pesquisa documental. Percebeu-se que passado e presente continuam entrelaçados como tênues fios que dão origem as peças em filigrana, e que essa manifestação artística, além de simbolizar, também fortalece o espaço em que está inserido.
The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer
Authors: Kuai Xiao-Yi , Lei Zhi-Yi , Liu Xiao-Shuang , Shao Xin-Yu 
Published: March 2020

Background:
Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity.
Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1
(GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the
underlying mechanism of the altered metabolism in CRC is still unknown.

Methods:
In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in
135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological
factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated.

Results:
Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC
tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1
showed a significantly strong link with FOXM1 in CRC tissue.

Conclusions:
Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.
PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway
Authors: Zhang Xiaohua , Zhong Shan 
Published: March 2020

Background:
Phosphoinositide-Dependent Kinase 1 (PDK1) is now widely studied in malignant
solid tumors. Researchers have previously revealed that targeting PDK1 is thought of as a promising anticancer
treatment strategy. The aim of this study was designed to evaluate the anticancer activity of GSK-470, a novel
and highly specific inhibitor of PDK1, in Pheochromocytoma (PCC) tumor model.

Methods:
PC12 cells were xenografted into nude mice to build PCC tumor model. Animals were treated with
GSK-470 vs vehicle. Mean tumor volume was calculated and compared across groups. TUNEL was used to
detect apoptosis. The effects of PDK1 inhibitor GSK-470 on activation of the Akt signaling and its downstream
Akt/mTOR pathway in xenotransplant tumor tissues were examined by western bolt.

Results:
The mean tumor volume in GSK-470 group was significantly less than that in control group. TUNEL
results found that cell apoptosis was markedly increased in GSK-470 group compared with the control group.
The western bolt analysis showed that the phosphorylation of Akt at threonine 308 was significantly reduced in
GSK-470 group. Also, GSK-470 strongly inhibited phosphorylation of mTOR on Ser2448, a marker for
mTORC1 activity, as well as phosphorylation of p70S6K, best characterized targets of mTOR.

Conclusion:
Our results showed that GSK-470 exhibited potent anticancer activity in PC12 tumor-bearing mice.
Also, we found that this effect appeared to be mediated by the inhibition of the Akt/mTOR pathway. The present
study once again provides new insights into the therapeutic effects of inhibiting PDK1 in the treatment of malignant
PCC. Therefore, we propose that GSK-470 might be an effective therapeutic agent for the treatment of
malignant PCC.
Evaluation of Anticancer, Antibacterial and Antioxidant Properties of a Medicinally Treasured Fern Tectaria coadunata with its Phytoconstituents Analysis by HR-LCMS
Authors: Reddy Mandadi N. , Adnan Mohd. , Alreshidi Mousa M. , Saeed Mohd. , Patel Mitesh 
Published: March 2020

Background:
Tectaria coadunata (T. coadunata) is an important fern species with a number of
medicinal properties. It has been evidently found for its effectiveness in ethanomedicinal usage, which can also
emerge as one of the most promising sources for nutraceuticals.

Objective:
This study aims to examine the phytochemistry of the whole crude extract of T. coadunata for the
first time with evaluation of antibacterial, antioxidant and anticancer activity.

Methods:
High Resolution Liquid Chromatography Mass Spectrometry analysis (HR-LCMS) was performed for
confirming the presence of biologically active constituents in the extract of T. coadunata followed by antibacterial,
antioxidant and anticancer activity.

Results:
With the detailed Mass spectra data, absorbance spectra and retention times, chemical composition of
T. coadunata holds a diverse group of bioactive/chemical components such as sugars, sugar alcohol, flavonoids,
terpenoids and phenolics. The results for antioxidant activity showed that T. coadunata crude extract had higher
scavenging potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals than H2O2 molecules, which
was followed by positive antibacterial activity against several pathogenic bacteria like Shigella flexneri, Staphylococcus
aureus and Salmonella typhi.

Discussion:
The ethanolic extract of T. coadunata showed favorable antiproliferation activity against three
leukemic (KG1, MOLT-3 and K-562) cells in a dose dependent manner, especially for KG1 42.850±1.24μg/ml.

Conclusion:
This study has provided a better understanding of the presence of biologically active phytochemical
constituents in the extract of T. coadunata, which can be the reason for its bioactive potential. Moreover,
T. coadunata has significant anticancer activities against human leukemic cancer cell lines, indicating it as a potential
anticancer agent.
Simultaneous Detection of Drug-resistant Mutations in Mycobacterium tuberculosis and Determining their Role through In Silico Docking
Authors: Nachappa Somanna Ajjamada , Neelambike Sumana M. , Sarikhani Ahmad , Ramachandra Nallur B. 
Published: March 2020

:
A molecular method for diagnosis of drug-resistant Tuberculosis is Multiplex allele-specific PCR (MAS-PCR), which is more time-efficient. Also, understanding the role of mutations when translated to protein, in causing resistance helps better drug designing.

Aims:
To study MAS-PCR in the detection of drug resistance in comparison to DNA sequencing, and understand the mechanism of interaction of drugs with mutant proteins in Mycobacterium tuberculosis.

Methods:
Detection of drug-resistant mutations using MAS-PCR and validation through DNA sequencing. MAS-PCR targeted four genes, iniA for the drug Ethambutol, rpsL and rrs for Streptomycin, and gyrA for Fluoroquinolone resistance, respectively. Further, the sequence data was analysed and modelled to study the effect on interaction of the anti-TB drug molecule with the target protein using in silico docking.

Results:
We identified drug-resistant mutations in four out of 95 isolates with one of them carrying a mutation at codon iniA501, two at gyrA94, and one for both iniA501 and gyrA94 using MAS-PCR. DNA sequencing confirmed drug-resistant mutations in only two isolates, whereas two others had mutation adjacent to the target allele. Molecular docking showed Estimated Free Energy of Binding (ΔG) being higher for Fluoroquinolone binding with GyrA D94V mutant. Both, wild and mutant IniA interact with EMB but had no significant effect on binding energy.

Conclusions:
DNA sequencing-based drug resistance detection of TB is more accurate than MAS-PCR. Understanding the role of mutations in influencing the drug-protein interaction will help in designing effective drug alternatives.
Technology Transfer in Poland: Overview
Authors: Jarzynowski Marcin 
Published: March 2020

:
The aim of this paper is to give an overview of the current state of
technology transfer in Poland by examining various stages of the process and
indicators associated with different actors involved. In order to examine the role of
technology in polish enterprises, it takes into account different forms of intellectual
property, both created and acquired in Poland. Data taken into consideration
include domestic and external sources, focused on the years 2013 - 2017. The main
sources of the statistics are the Polish Patent Office and the Central Statistics
Office.

:
Phenomena observed in the data are supported and elaborated by domestic research
articles concerned with technology transfer and open innovation. The most striking
feature of such juxtaposition is the fact, that some of the indicators presented in the
article are surprisingly low, considering overall economic situation.

:
All of the above represents the context of the Open Innovation Network project,
which is also presented in the paper. Interpretation of the presented results is
included in the discussion section. Some of the indicators confirm the status of
polish economy as moderately innovative, however trends in performance of a
small group of technical universities show a promising development in the field of
technology transfer.
Una crítica reciente a la noción de significado literal
Authors: Dascal Marcelo 
Published: March 2020

Between two opposite conceptions about meaning, the traditional one of “literal meaning” and what I have called “Contextualism “ (Dascal, 1981), there is an alternative which I have dubbed “Moderate Literalism”, and defended in another place (Dascal, 1983).
Contextualism as I understand it is the view that linguistic expressions lack “literal” meaning established by rules of language, and asserting that they get their meanings only as a function of the context within which they are used.
My view of moderate literalism does not exclude literalism but it does modify this view taking off its excess weight. According to my view, the excessive demands made by the traditional conception on literal meaning are left aside, such as: it be sufficient to determine truth conditions and illocutionary force; that is always be a part of the message transmitted by the speaker; that it cannot be cancelled or neutralized in any context of use, etc.
In this paper I do not intend to expound my proposal —this I have done elsewhere (Dascal, 1983)— but to discuss some recent criticisms against the notion of literal meaning. Gibbs (1984) tried to show that from the viewpoint of the psychology of language understanding, this notion does not play the role which had been attributed to it.
A detailed discussion of the criticism will have as an outcome —according to me— that it is unnecessary to go from the traditional conception to radical contextualism, and that the notion of literal meaning, modified in due form, retains its validity and a crucial relevance for the psychological explanation of the process of understanding utterances.
I will consider certain of Gibbs’ theoretical objections to the notion of literal meaning (section 2); afterwards I will take his empirical arguments (section 3), and conclude with a discussion of the implications that the author attributes to his criticism.
[J.A. Robles]
Sobre a lógica deôntica não-clássica
Authors: Puga Leila Z. , Da Costa Newton C.A. 
Published: March 2020

Our starting point, in this basically expository paper, is the study of a classical system of deontic propositional logic, classical in the sense that it constitutes an extension of the classical propositional calculus. It is noted, then, that the system excludes ab initio the possibility of the existence of real moral dilemmas (contradictory obligations and prohibitions), and also can not cope smoothly with the so-called prima facie moral dilemmas. So, we develop a non-classical, paraconsistent system of propositional deontic logic which is compatible with such dilemmas, real or prima facie. In our paraconsistent system one can handle them neatly, in particular one can directly investigate their force, operational meaning, and the most important consequences of their acceptance as not uncommon moral facts.
Of course, we are conscious that other procedures for dealing with them are at hand, for example by the weakening of the specific deontic axioms. It is not argued that our procedure is the best, at least as regards the present state of the issue. We think only that owing, among other reasons, to the circumstance that the basic ethical concepts are intrinsically vague, it seems quite difficult to get rid of moral dilemmas and of moral deadlocks in general. Apparently this speaks in favour of a paraconsistent approach to ethics. At any rate, a final appraisal of the possible solutions to the problem of dilemmas and deadlocks, if there is one, constitutes a matter of ethical theory and not only of logic. On the other hand, the paraconsistency stance looks likely to be relevant also in the field of legal logic.
It is shown, in outline, that the systems considered are sound and complete, relative to a natural semantics. All results of this paper can be extended to first-order and to higher-order logics. Such extensions give rise to the question of the transparency (or oppacity) of the deontic contexts. As we shall argue in forthcoming articles, they normally are transparent.
[L.Z.P., N.C.A. da C.] (PDF en portugués)
La justificación práctica del principio de no contradicción en Aristóteles
Authors: Cassini Alejandro 
Published: March 2020

The paper considers an Aristotelian argument to justify the principle of non contradiction given in Metaphysics 1008b 12-31. This is a practical argument, because it refers to human action and its explanation. First, the article outlines the argument, which is shown to be incomplete. Then, it analyses two fundamental assumptions of the argument: a) the explanation of actions; b) the rationality of actions. The first state that all actions can be explained by means of a desire and a relevant belief; the second, that all actions are rational. It affirms that there are Aristotelians grounds to support both assumptions, despite the existence of akrasía or incontinent action. Finally, it shows that the argument, with these two assumptions as additional premises, is complete and it has inductive plausibility.
[A.C.]
Explanation, Causation and Laws
Authors: Edgington Dorothy 
Published: March 2020

En tanto que el profesor Salmon argumenta en favor de la paridad entre causación y reyes (Véase su ensayo “Scientific Explanation: Causation and Implication”, en pp. 3-21 de este número de Crítica), yo argumento en favor de la prioridad: afirmo que la causación es esencial a la explicación de por qué suceden las cosas o por qué ciertas cosas son verdad; las leyes son un lujo, un elemento adicional optativo.
1. Explicar algo es hacerlo inteligible o susceptible de ser entendido. En este artículo sostengo que hay una estrecha conexión entre la explicación y la causación. Primeramente examino la explicación de ciertos fenómenos humanos —el lenguaje, las convenciones, la conducta humana en general y la vida mental. La aplicación de la noción de explicación a estas cuestiones es poco problemática, pues ellas no existirían si no fuese posible entenderlas.
2. Paso a considerar la pregunta “¿por qué tal y cual cosa es el caso?” para el caso del mundo no humano. ¿Hay algo que tenga que ser entendido? ¿En qué consiste este entendimiento? Argumento que la respuesta más obvia a estas preguntas recurre a la noción de causación.
3. ¿Por que esta noción es materia de controversia? Porque, desde Burne, la causalidad, en tanto que manera como se relacionan los sucesos en el mundo, ha sido metafísicamente sospechosa debido a los problemas epistemológicos que supone. Hume argumentó que no podemos conocer esa relación (a) a priori ni (b) mediante la observación.
4. Argumento que tanto (a) como (b) son problemáticas, En último término, cualquier descripción de “los hechos” tiene implicaciones causales.
5. Lo anterior explica el fracaso de los intentos de “analizar” la causalidad en términos que no la presupongan.
6. Examino la propuesta de Hempel y pongo de relieve que el fracaso de su intento de proporcionar una condición necesaria mediante la noción de “inferencias a partir de leyes”, refleja el fracaso del análisis de la causación en términos de regularidades o leyes.
7. Pregunto si acaso Hempel proporciona condiciones necesarias para la explicación; esto es, si (a) tenemos que conocer leyes para poder dar una explicación y (b) si tiene que haber leyes (deterministas o probabilistas) que gobiernen el comportamiento de lo que se pretende explicar. Contesto que “no” a ambas preguntas.
8. Finalmente, encuentro varias dificultades en la idea de que las llamadas “leyes de alto nivel” que no son causales (tales como las leyes de la conservación, los principios de equivalencia, etc.) explican por qué sucede algo.
Tutkimusjulkaisujen avoin saatavuus. Tutkimusyhteisön kansallinen linjaus ja toimenpideohjelma 2020–2025
Authors: Avoimen tieteen ja tutkimuksen koordinaatio  
Published: March 2020

Tutkimusjulkaisujen avoimen saatavuuden linjauksen tavoitteena on taata tutkimusyhteisölle ja tutkimustiedon soveltajille pääsy tutkittuun tietoon tavalla, joka ei ole koskaan ennen ollut mahdollista. Linjaus määrittelee periaatteet, tavoitteet ja toimenpiteet, joihin sitoutumalla ja joita edistämällä tutkimusyhteisö Suomessa voi saavuttaa tasavertaisen pääsyn tutkitun tiedon äärelle.
Linjaus koostuu yhteisistä periaatteista ja osalinjauksista, joissa määritellään tavoitteita ja toimepiteitä. Periaatteissa määritellään yleiset ehdot tutkimusjulkaisujen avoimen saatavuuden tavoittelulle. Ne sanoittavat tutkimusyhteisölle tärkeitä periaatteita, joista on pidettävä kiinni avoimuuden saavuttamiseksi.
Common cardiac comorbidities and perioperative assessment modalities for liver transplant candidates – an update
Authors: Hackl F. , Kopylov A. V. , Kaufman M. D. 
Published: March 2020

Cardiac complications are currently the leading cause of early mortality following liver transplantation. Guidelines for the cardiac workup prior liver transplantation are limited. In this review we are discussing commonly modalities used for cardiovascular evaluation of liver transplant candidates.Authors declare no conflict of interest.
PHENOMENON OF DEMIKHOV. In the Sklifosovsky Institute (1960–1986). Demichow W. Die experimentelle Transplantation lebenswichtiger Organe. Berlin: VEB Verlag Volk und Gesundheit, 1963
Authors: Glyantsev S. P. , Werner A. 
Published: March 2020

The article has discussed V.P. Demikhov's views on a homoplastic transplantation of tissues and organs in 1963 and his achievements in experimental transplantation by that time. The authors first translated the monograph Die experimentelle Transplantation lebenswichtiger Organe (1963) from German into Russian and presented V.P. Demikhov's Preface to it. In this text, having critically analyzed the current provisions in the field of immunobiology, V.P. Demikhov came to the conclusion that a number of his achievements contradicted those provisions and did not fit into the framework of existing immunobiological laws. In 1963, confessing the primacy of function over structure, V.P. Demikhov believed that the restoration of blood circulation in transplanted organs played the main role in their survival, and the subsequent functioning of the transplanted organ for a long time meant its engraftment. In this text V.P. Demikhov for the first time substantiated the model of a “physiological organism” he had invented for reviving a human in a state of agony, for creating a bank of organs, growing it in infants and rejuvenating the elderly.Authors declare no conflict of interest.
Peran Religiusitas terhadap Konformitas pada Mahasiswi Berhijab
Authors: Juniarly Amalia , Dahtiarani Dira 
Published: March 2020

The study aims to determine the role of religiosity on conformity in hijab female students. The study population was university X students whom wear hijab, and with aged 18-23 years old. The research sample used 160 people and for try out with 50 people. This study used sampling quota techniques. Religiosity and conformity was measured by the scale which refers to the dimensions of religiosity from Ancok and Suroso (2011) and type of conformity from Nail, Domenico and McDonald (2013). The research used simple regression analysis. The result obtained by value of RR = 0.559, R square = 0.313, F = 71.884, P = 0.000 (p <0.05), it meaning that there is a significant role of religiosity towards conformity. Thus the hypothesis proposed is accepted.
Analysis of world practice of cash circulation
Authors: Markova Olga Mikhailovna 
Published: March 2020

Nowadays, attention is being paid to studying the structure of money circulation in foreign countries, which is stipulated by changes in cash monetization of the economy and the role of cash and financial operations performed with cash. According to the results based on the national and foreign research of cash circulation, the advantages and disadvantages of using cash in money turnover have been identified. The rating of countries with the least dependence on cash is given. It has been stated that in the developed countries the bank cards are used as an alternative to cash, the sizes of which vary depending on the location and characteristics of consumer lending in them. The problem is being studied: what reasons stimulate the demand for cash? The factors that influence the cash providing the goods and services circulation, other payments of the population
of various countries (assessment of motives for holding money, total demand for cash, transactional, cumulative and speculative or portfolio costs have been given). Cash needs planning also plays an important role. In the Bank of Russia cash need planning is provided on the forecast estimates for all face values of coins and banknotes. A review of a sample of cash circulation and factors affecting it in Russia for the period from 1998 to 2018 is presented. The graphs of changes in the money supply and its growth rates, gross domestic product and its growth rates are illustrated. A correlation matrix is built for all variables in the sample (growth rates). The conclusions are drawn about the need in the monetary mechanism for regulating cash circulation to maintain the national independence and statehood in the context of digitalization of the world economy on a global scale.