bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN KUANTITATIF STRUKTUR TOKSISITAS : REVIEW
Authors: Purwaniati Purwaniati 
Published: September 2020

AbstrakProses penemuan dan pengembangan obat merupakan proses panjang yang memerlukan banyak waktu dan biaya. Ada banyak calon molekul obat yang gagal mencapai pasaran karena alasan toksisitasnya yang tinggi, sehingga harus dapat diidentifikasi sedini mungkin. Hubungan kuantitatif struktur toksisitas (HKST) merupakan salah satu metode in silico yang cukup tangguh untuk memprediksi toksisitas. HKST merupakan persamaan matematis yang dibentuk dari variabel data endpoint toksisitas seperti LD50 sebagai variabel terikat dan sejumlah deskriptor sebagai variable bebas yang dihitung dari senyawa-senyawa dalam training set. Persamaan HKST kemudian digunakan untuk memprediksi toksisitas senyawa baru.Kata kunci : toksisitas, hubungan kuantitatif struktur toksisitas (HKST)AbstractThe process of drug discovery and development is a long process that requires a lot of time and costly. There are many prospective drug molecules that fail to reach the market due to high toxicity reasons, so they must be identified as early as possible. The quantitative structure toxicity relationship (QSTR) is one of the in silico methods that is strong enough to predict toxicity. QSTR is a mathematical equation formed from endpoint toxicity data variables such as LD50 as a bound variable and a number of descriptors as independent variables calculated from the compounds in the training set. The QSTR equation is then used to predict the toxicity of new compounds.Keywords: toxicity, quantitative structure toxicity relationship (QSTR)
FAKTOR PREDISPOSISI, PEMUNGKIN DAN PENDORONG DALAM PENINGKATAN PARTISIPASI LAKI-LAKI PADA KEGIATAN POSYANDU DI KABUPATEN LEBAK
Authors: Iswanto Rery Kurniawati Danu , Husnida Nintinjri , Sutianingsih Hani 
Published: September 2020

Abstrak
Rery Kurniawati Danu Iswanto, Nintinjri Husnida, Hani Sutianingsih*
Korespondensi: bundamanua@yahoo.com

Suatu model promosi, edukasi, dan perubahan perilaku kesehatan akan efektif jika didukung oleh partisipasi aktif dari peran laki-laki. Akan tetapi, posyandu sebagai layanan kesehatan terdepan bagi ibu dan anak pada umumnya di masyarakat hanya dikelola oleh sumber daya perempuan mulai dari tenaga kesehatan, kader, dan sasarann. Berdasarkan hal tersebut diteliti suatu model layanan posyandu yang melibatkan laki-laki dalam setiap aspeknya baik tenaga kesehatan, kader, maupun sasarannya. Salah satu teori perubahan perilaku yang relevan dalam menggambarkan rangkaian upaya perubahan perilaku kesehatan mulai dari perencanaan sampai dengan menyelesaikan masalah kesehatan masyarakat adalah teori perubahan perilaku oleh L. Green (1979). Dengan model pendekatan ini diharapkan akan menguatkan layanan posyandu dan berdampak pada peningkatan derajat kesehatan masyarakat.
Desain penelitian ini adalah analisis kualitatif melalui beberapa tahap penelitian. Tahap pertama akan dilakukan studi pendahuluan pada beberapa posyandu dimana subyek penelitian tinggal untuk menggali karakteristik sosial masyarakatnya. Selanjutnya melakukan diskusi fokus grup untuk menggali faktor predisposisi, faktor pemungkin, dan faktor pendorong dalam kaitannya dengan partisipasi laki-laki di posyandu. Tahap ketiga disusun suatu model atau skema pendekatan teori Green (1979) dalam peningkatan partisipasi laki-laki berdasarkan dari data penelitian. Adapun data diolah dan disajikan secara kualitatif.
Hasil penelitian menunjukkan faktor predisposisi responden sebagai kader posyandu, pekerjaan pokok responden adalah untuk menafkahi keluarga, sebagai pengisi waktu luang, dan motivasi. Sebagai sasaran posyandu, tingkat pendidikan dan jenis pekerjaan. Faktor enabling ditemukan sebagai kader posyandu: sarana/prasarana dan kompensasi. Sebagai sasaran posyandu: jadwal posyandu. Dan faktor pendorong sebagai kader posyandu, dukungan puskesmas/dinas kesehatan dan dukungan tokoh masyarakat. Sebagai sasaran posyandu, dukungan keluarga dan dukungan pekerjaan.

Kata Kunci : Faktor Predisposisi, Faktor Pemungkin, Faktor Pendorong, Partisipasi Laki-laki, Posyandu
Referensi : 11 (1993-2014)
*Dosen Jurusan Kebidanan Rangkasbitung Poltekkes Banten
PERBANDINGAN STROKE NON HEMORAGIK DENGAN GANGGUAN MOTORIK PADA PASIEN YANG MEMILIKI FAKTOR RESIKO DIABETES MELITUS, HIPERTENSI, DIABETES MELITUS & HIPERTENSI DI RSUD DR.H ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2018
Authors: Sari Nia Permata , Dharmawita Dharmawita , Sudiadnyani Ni Putu , Fitriyani Fitriyani 
Published: September 2020

PROGRAM STUDI KEDOKTERAN UMUM
FAKULTAS KEDOKTERAN UNIVERSITAS MALAHAYATI
Skripsi, April 2020
NIA PERMATASARI
PERBANDINGAN STROKE NON HEMORAGIK DENGAN GANGGUAN MOTORIK PADA PASIEN YANG MEMILIKI FAKTOR RESIKO DIABETES MELITUS , HIPERTENSI, DIABETES MELITUS & HIPERTENSI DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2018
xv + 60 Halaman + 14 Tabel + 4 Gambar + Lampiran

ABSTRAK
Latar Belakang: Stroke di Indonesia juga mengalami peningkatan prevalensi. Di Indonesia penyakit ini menduduki posisi ketiga setelah jantung dan kanker. Pada tahun 2007, hasil Riset Kesehatan Dasar (Riskesdas) menunjukkan data 8,3 per 1000 penduduk menderita stroke Stroke juga menjadi penyebab kematian utama di hampir semua rumah sakit di Indonesia, yakni sebesar 14,5%.
Tujuan Penelitian: Mengetahui bagaimana Perbandingan Gangguan Motorik Pada Pasien Stroke Non Hemoragik Pasien Dengan Faktor Resiko Diabetes Melitus, Hipertensi, Diabetes Melitus & Hipertensi Di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Tahun 2018.
Metode Penelitian: Rancangan penelitian ini adalah Analitik Deskriftif dengan pendekatan secara Cross sectional. Subjek penelitian ini seluruh pasien Gangguan Motorik Pada Stroke Non Hemoragik Dengan Faktor Resiko Diabetes Melitus, Hipertensi, Diabetes Melitus dan Hipertensi di RSUD Dr. H. Abdul Moeloek Provinsi Lampung.
Hasil Penelitian: Sampel penelitian ini 30 pasien. Stroke non hemoragik pada pasien hipertensi sebanyak (92,6%), stroke non hemoragik pada pasien diabetes melitus sebanyak (81,5%), Stroke non hemoragik pada pasien hipertensi dan diabetes melitus sebanyak (74,1%). Dengan menggunakan uji Kolmogorov-Smirnov Z nilai signifikannya adalah 0,280 (p=0,280>α=0,05) maka Ho diterima.
Kesimpulan: Tidak ada perbandingan hipertensi pada stroke non hemoragik dengan gangguan motorik ringan dan sedang di RSUD Dr.H. Abdul Moeloek Provinsi Lampung Tahun 2018.

Kata Kunci: Gangguan Motorik, Stroke Non Hemoragik, Hipertensi, Diabetes Melitus
Pustaka: 19 (2007-2018)
Determinan Hasil IVA Positif di Wilayah Kerja UPT BLUD Puskesmas Meninting Lombok Barat
Authors: Suseno Mutiara Rachmawati , Imani Rossary Dirgahayu Setia 
Published: September 2020

Skrining IVA sangat sesuai dengan kondisi negara berkembang seperti Indonesia, karena tekniknya mudah, sederhana, biaya rendah/ murah, tingkat sensitifitasnya tinggi, cepat dan akurat untuk menentukan kelainan pada tahap pra-kanker. Skrining IVA mulai diperkenalkan di Indonesia oleh Kementerian Kesehatan pada tahun 2007, dengan didahului pengembangan pada 6 lokasi pilot project, kemudian dikembangkan ke daerah lain di seluruh Indonesia. Di NTB tahun 2015 sendiri berdasarkan profil kesehatan Provinsi NTB prevalensi kanker leher rahim sejumlah 8.020 jiwa dan ditemukan IVA positif 146 kasus, pada tahun 2016 prevalensi kanker leher rahim sejumlah 14.431 jiwa dan ditemukan IVA positif 290 kasus. Berdasarkan data tahun 2014 yang didapat dari RSUP NTB , penderita kanker serviks sebesar 12,8%, meninggal 2%. Tujuan penelitian ini adalah untuk mengetahui faktor apakah yang berhubungan dengan hasil IVA positif. Jenis penelitian analitik cross-sectional. Populasi dalam penelitian ini adalah semua pasien yang datang melakukan pemeriksaan IVA di UPT BLUD Puskesmas Meninting dari Januari s/d Desember 2017 sebanyak 885 orang. Pengambilan sampel penelitian menggunakan teknik pemilihan secara total sampling yaitu dimana semua populasi yang berjumlah 885 pengunjung dijadikan sampel penelitian. Analisa dilakukan dengan uji statistik Chi-Square. Berdasarkan analisis Chi-Square menunjukkan p value <0,05 (p value 0,000) sehingga ada hubungan yang signifikan antara IMS dengan hasil IVA positif . Terdapat hubungan antara faktor IMS, Pekerjaan sampel, dan Alat kontrasepsi pada sampel dengan hasil IVA Positif di UPT BLUD Puskesmas Meninting Tahun 2018.
Meningkatkan Keamanan Web Menggunakan Algoritma Advanced Encryption Standard (AES) Terhadap Seragan Cross Site Scripting
Authors: Putra Yendi , Yunus Yuhandri , Sumijan S 
Published: September 2020

Pada era milenial internet menjadi sebuah kebutuhan yang sangat mendasar guna menunjang aktifitas masyarakat dalam berbagai bidang salah satunya bidang pendidikan. SMK Maritim Nusantara dalam menunjang proses pembelajaran mengunakan aplikasi berbasis web dengan nama e-learning yang digunakan oleh guru dan siswa. Website sekolah memiliki beberapa dokumen dalam bentuk digital yang harus di jaga kerahasianya seperti data siswa, data guru, nilai siswa. Hasil scaning dari aplikasi Acunetix WVS 10.5 diperoleh informasi tentang celah keamanan yang terdapat pada website https://www.e-learning.smkmn.sch.id, dengan hasil diantaranya terdapat 8 (delapan) serangan dengan rincian, 2 (dua) kategori hight dengan nama serangan Cross site scripting (XSS), 4 (empat) kategori medium dengan nama serangan HTML form without CSRF protection dan 2 (dua) kategori low dengan nama serangan Password type input with auto-complete enabled. Kategori serangan yang paling berbahaya/hight yaitu XSS. Serangan XSS adalah serangan yang menyisipkan kode-kode jahat berbentuk javascript melalui form input yang bertujuan untuk mencuri cookie lalu menggunakan cookie tesebut untuk masuk kedalam web secara sah sehingga data dapat dimanipulasi bahkan dihapus. Untuk itu dibutuhan sebuah sistem yang kuat untuk menjaga keamanan, kerahasiaan data-data sekolah, salah satu cara yang dapat digunakan adalah dengan penerapan Algoritma Advance Enkripiton Standart (AES), algoritma ini memiliki tingkat keamanan yang tinggi serta menggunakan memori yang sedikit dalam pengoperasianya sehingga tidak membebani proses dan mudah untuk diterapkan. Hasil penelitian yang dilakukan dengan menerapkan Algoritma AES mejelaskan bahwa sebelumnya terdapat 2 (dua) kerentanan kategori hight dengan nama serangan XSS, setelah implementasi Algoritma AES maka kerentanan serangan XSS tersebut tidak ditemukan lagi. Berdasarkan hasil yang diperoleh dalam penelitian dapat disimpulkan bahwa Implementasi Algoritma AES pada token dapat meningkatkan keamanan website https://www.e-learning.smkmn.sch.id dari serangan XSS
SPIRITUAL EMOTIONAL FREEDOM TECHNIQUE (SEFT) SEBAGAI UPAYA PROMOTIF DAN PREVENTIF DALAM PERAWATAN PALLIATIF DI DESA SAKATIGA
Authors: Wahyuni Dian 
Published: September 2020

Tujuan: dapat mengetahui hasil pengukuran tekanan darah, dapat mengetahui perubahan pengetahuan dan sikap masyarakat tentang SEFT, dapat mengeksplor pengetahuan masyarakat tentang penyakit yang dideritanya, dapat melakukan SEFT secara mandiriMetode: III yaitu penyuluhan, peragaan SEFT dan pemeriksaan tekanan darahHasil: 100% penduduk yang hadir dalam pengmas telah diperiksa tekanan darah; 86% penduduk yang hadir dalam pengmas dapat menyebutkan pengertian, tujuan SEFT; 86% penduduk yang hadir dalam pengmas menceritakan keluhan dan penyakit yang dirasakan; 50% penduduk yang hadir dalam pengmas dapat mempraktikan SEFT secara mandiri.Simpulan: tujuan kegiatan tercapai
Diagnostic Outcomes for Genetic Testing of 54 Genes in Pregnancy Loss Using Array CGH Method: A Two-Year Retrospective Study
Authors: PAKSOY Barış , OZDEMIR Ozturk , SILAN Fatma 
Published: September 2020

Objective: The current study aimed to retrospectively evaluate different diag- nostic approaches for the array genetic analysis of the cases from all trimester fetal loss in the medical genetics clinic between 2016 and 2017. The Quantitati- ve Fluorescent Polymerase Chain Reaction(QFPCR) test was performed on 50 samples, and aneuploidy was detected in 11 samples as a result of the test, and the array-CGH was performed when 39 QF-PCR resulted in normal test results. Under this purpose, we aimed to analyze and determine the possible copy num- ber variation(CNV), gene deletions, and/or duplications involved in embryonic cell division, tissue differentiation, intended.Materials and methods: DNA isolation from cases of this retrospective study was completed using the PureLink Genomic DNA isolation kit. DNA samples were then genoty - ped for molecular etiological reasons by oligonücleotid microarray -CGH method (aCGH , 60 K ISCA design , Agilent , Germany ). Hybridized probe correlations of the case and reference DNAs were evaluated with databases (Database of Genomic Variants Analysis ) used in genomic variation analysis in terms of 54 functional genes CNVs associated with intrauterine losses.Results: CNV was detected in 30 (77%) of 39 fetal samples analyzed within the scope of the research. Fifty-five percent of CNVs were found to be duplication (55%) and forty-five percent were deletions (45%). As a result of the evaluation, deletion was detected in 19 (35%) of 54 genes, duplication was detected in 26 (48%), while in 3 (6%) both deletion and duplication were detected. Although CNV detected in autosomal chromosomes (chromosome 1, 2, 3, 4, 5, 7, 8, 10, 12, 13, 14, 15 and 20), CNV was established the most common in X chromosome. In our study, CNVs associated with COX7B, ZIC1, MECP2, FMR1, HOXD13, JAG1, MSX2, NEXN, and SIX3 genes were found to be more frequent in terms of fetal loss etiology.Conclusions: Based on our experience, the array-CGH method can be used to investigate the etiology of the normal results of QF-PCR in cases of fetal loss. The array CGH method will be preferred more and more due to the ease of application and the data obtained. When we look at the literature, it is seen that there is not enough research on array CGH about fetal loss and more studies are needed to increase the experience in this field.
<em>Un giorno in Medicina. Un viaggio attraverso le opinioni degli internisti FADOI e degli infermieri ANÌMO</em>
Authors: Pastorelli Guest Editors: Ruggero , Bordin Gabriella 
Published: September 2020

Un giorno in Medicina. Un viaggio attraverso le opinioni degli internisti FADOIA. Fontanella

Analisi della survey Un giorno in Medicina. Un viaggio attraverso le opinioni degli internisti FADOIR. Pastorelli, C. Santini
Gli indicatori della qualità dell’assistenza nelle Unità Operative di Medicina Interna secondo gli Internisti FADOIM.S. Fiore, F. Tiratterra
L’attività clinica nelle Unità Operative di Medicina Interna: gli aspetti gratificanti e quelli da modificareD. Terracina, G. Campagna
Problematiche organizzative ed assistenziali nella gestione del paziente critico in Medicina InternaF. Pieralli, C. Nozzoli
I rapporti delle UO di Medicina Interna con il DEA e l’OspedaleA. Franco, G. Ballardini
La Medicina Interna: ponte naturale fra Ospedale e TerritorioT.M. Attardo, S. De Carli, R. Re
Analisi della survey Un giorno in Medicina. Un viaggio attraverso le opinioni degli infermieri ANÌMO G. Bordin, R. Pastorelli
Un giorno in Medicina. I risultati delle Survey FADOI e ANÌMO: quanto vicini, quanto lontani A. Maffettone, G. Bordin
Il core competence dell’infermiere in Medicina Interna: evoluzione e opportunitàM. Piasentin, F. Bertoncini
Gli esiti sensibili all’assistenza infermieristica in Medicina InternaL. Tesei, C. Gatta
Covid-19 Pandemic's Impact on Eating Habits in Saudi Arabia
Authors: Alhusseini Noara , Alqahtani Abdulrahman 
Published: September 2020

Background COVID-19 virus has been reported as a pandemic in March 2020 by the WHO. Having a balanced and healthy diet routine can help boost the immune system, which is essential in fighting viruses. Public Health officials enforced lockdown for residents resulting in dietary habits change to combat sudden changes. Design and methods A cross-sectional study was conducted through an online survey to describe the impact of the COVID-19 pandemic on the eating habits, quality and quantity of food intake among adults in Saudi Arabia. SPSS version 24 was used to analyze the data. Comparison between general dietary habits before and during COVID-19 for ordinal variables was performed by Wilcoxon Signed Rank test, while McNemar test was performed for nominal variables. The paired samples t-test was used to compare the total scores for food quality and quantity before and during COVID-19 periods. Results 2706 adults residing in Riyadh completed the survey. The majority (85.6%) of the respondents reported eating homecooked meals on a daily basis during COVID-19 as compared to 35.6% before (p<0.001). The mean score for the quality of food intake was slightly higher (p=0.002) before the COVID-19 period (16.46±2.84) as compared to the during period (16.39±2.79). The quantity of food mean score was higher (p<0.001) during the COVID-19 period (15.70±2.66) as compared to the before period (14.62±2.71). Conclusion Dietary habits have changed significantly during the COVID-19 pandemic among Riyadh residents. Although some good habits increased, the quality and the quantity of the food was compromised. Public Health officials must focus on increased awareness on healthy eating during pandemics to avoid negative consequences. Future research is recommended to better understand the change in dietary habits during pandemics using a detailed food frequency questionnaire.
Optimal free export/import regions
Authors: Dweik Samer 
Published: September 2020

AbstractWe consider the problem of finding two free export/import sets
$E^+$
and
$E^-$
that minimize the total cost of some export/import transportation problem (with export/import taxes
$g^\pm $
), between two densities
$f^+$
and
$f^-$
, plus penalization terms on
$E^+$
and
$E^-$
. First, we prove the existence of such optimal sets under some assumptions on
$f^\pm $
and
$g^\pm $
. Then we study some properties of these sets such as convexity and regularity. In particular, we show that the optimal free export (resp. import) region
$E^+$
(resp.
$E^-$
) has a boundary of class
$C^2$
as soon as
$f^+$
(resp.
$f^-$
) is continuous and
$\partial E^+$
(resp.
$\partial E^-$
) is
$C^{2,1}$
provided that
$f^+$
(resp.
$f^-$
) is Lipschitz.
Multi-objective optimization of mixed model assembly line balancing in an assemble-to-order industry with stochastic environment
Authors: Legesse Ayele , Tesfaye Ermias , Berhan Eshetie 
Published: September 2020

The objective of this research is to propose a methodology for multi-objective optimization of a mixed-model assembly line balancing problem with the stochastic environment. To do this a mathematical model representing the problems at hand is developed with objectives of minimizing cycle time and minimization of the number of workstations (which is of Type-E ALB problem). And two optimization meta-heuristics are considered to solve it, namely, Non-Dominated Sorting Genetic Algorithm- II (NSGA-II) and Multi-Objective Genetic Algorithm (MOGA). To test the performance of the algorithms three different size standard problems in Assemble-to-order types of industry are taken and five demand arrival scenarios are considered to incorporate the stochastic nature of the demand arrival for each model in all problems. Both the algorithms are coded and run using MATLAB® 2013a and are compared based on different performance measures. The results indicated that MOGA outperformed NSGA-II in most of the test problems. Nevertheless, both algorithms have resulted in significant improvements in the performance measures in Assemble-to-order types of industry dataset compared to the existing line configuration.
Keywords: Assembly Line, Multi-objective optimization, Single model, mixed-model, stochastic environment, Genetic Algorithm
Tracking local brittle zone in the heat affected zone of girth-welded API 5L x46 pipe
Authors: Amuda M.O.H. , Osob L. O. , Etuk N.N. , Lawal T. F. , Adetayo A.O. 
Published: September 2020

In this study, microhardness variation as well as macro and micro structural examination of the heat affected zone (HAZ) of a girth welded API 5L X46 pipeline material were conducted as a means of tracking local brittle zone (LBZ) in the HAZ region. The weldment analysed were built from heat input range of 695 J/mm – 2567 J/mm. Analysis of the results revealed that the HAZ profile changes with variation in the heat input and becomes shallow but wider as the heat input increases. Defects free welds were achieved under the heat input range of 1650 J/mm – 2017 J/mm welding condition. Localized high hardness values were obtained at certain locations within the HAZ of intermediate heat input welds produced at 1467 J/mm due to thermal stresses induced strains at this heat input in the resolidified weld. Other than this, non-equilibrium rapid heating/cooling that is common during welding as well as the magnitude of mechanical strain generated on cooling vary with heat input and was attributed to the development of high hardness value at localized region within the HAZ of the welds in low heat input welding condition. The macrographic profile at these locations, contrasted against that of a failed pipeline material of similar specification obtained from typical oil and gas infrastructure, established that crack initiation and propagation followed the trend of microhardness variations in the girth welded pipe. The crack initiates at specific location in the HAZ with very high hardness in the range 186-216 Hv within a radius of about 3-5 mm from the edge of the fusion zone.
Keywords: API 5L X46; Girth welding; Heat input; Heat affected zone; Local brittle zones
Development of a petroleum pipeline monitoring system for characterization of damages using a Fourier transform
Authors: Aba E.N. , Olugboji O.A. , Nasir A. , Olutoye M.A. , Adedipe O. 
Published: September 2020

Significant damage to the environment and huge economic losses are potential problems caused by leakage from petroleum pipelines. The occurrence of a leakage in a pipeline throughout its lifetime is very difficult to prevent. To minimize environmental damage and high economic losses, an efficient pipeline monitoring system is required to carry out damage characterization thereby enhancing quick response. The signal processing technique of sampling and reconstruction was adopted and mathematical algorithms for the characterization of damages in pipes were developed using the Fourier transform method. These were simulated with the results showing a good agreement between the shapes and magnitudes of the measured original and reconstructed pulses. The simulation was verified with experiments on the test rig. The results showed an underestimation in the magnitudes of the reconstructed pulses in the range of 40 – 45 %. This problem was solved by using a factor K obtained by dividing the maximum amplitude value of the original pressure pulse by that of the reconstructed pulse. Reconstruction of the measured original pulse at a damage location was achieved from combining the measured pulses from two other close locations using the developed Fourier transform based model.
Keywords: Damage Pipeline-monitoring Characterization Fourier transform Reconstruction