bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agreement of Primary Outcomes in Chiropractic-Related Clinical Trials Registered in clinicaltrials.gov with Corresponding Publication.
Authors: Cote Robert , Perle Stephen , Martin Derek 
Published: July 2020

Abstract
Introduction:Previous analysis of registered clinical trials has found a disappointing number of study protocols result in publications which change what the registered a priori primary outcome measure is. Likewise, there is a disappointing rate of unpublished trials. Similar research has not been published on chiropractic-related studies. Primarily this investigation determined if reported primary outcomes in chiropractic-related clinical trials registered in clinicaltrials.gov match their published results. Secondarily, other outcome measures and publication status are assessed.Methodology:Clinicaltrials.gov was searched for chiropractic-related trials, using the search terms “chiropractic”, “chiropractor”, and having a completed status. Publication status was determined by searching PubMed (pubmed.gov), Index to Chiropractic Literature (chiroindex.org), and Google Scholar (scholar.google.com) through 29 May 2020. If the study was published, outcome measures were compared between the clinicaltrials.gov entry and the published paper to assess for consistency by two independent investigators. If there was disagreement between investigators, a third evaluated the data and decided if the published paper agreed with the clinicaltrials.gov entry.Results:Within clinicaltrials.gov 171 chiropractic-related protocols were identified. Twenty-five (25) had results posted and 102 were published. Twenty-nine of those entries produced multiple papers consisting of protocols, plot/feasibility studies, clinical trials, and poster presentations. Of the 102 studies published, 92 (90.2%) had agreement between their primary outcome and the listed entry on clinicaltrials.gov and 82 (80.4%) agreed with the secondary outcomes in the registered protocol. Entries on clinicaltrials.gov had a 59.6% (102/171) publication rate and a 14.6% (25/171) rate of displaying their results. Conclusion:A modest rate of agreement (90.2%) between clinicaltrails.gov entries and the 102 published papers (59.6% publication rate) were found. While chiropractic-related clinical trials are fewer in number compared to medical trials, chiropractic-related research has a substantially better rate of primary and secondary outcome concordance with registered protocols and a better publication rate. Investigators need to continue to upload results onto clinicaltrials.gov and seek publication regardless of the study findings. It is important to publish negative results so as not to introduce publication bias into systematic reviews and meta-analyses. Both positive and negative findings are important when evaluating treatments and determining the best care for patients.
Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD: Interim Results a Non-randomized, Open-label, Phase 1 Clinical Study
Authors: Zhao Ye , Li Xuwei , ZHOU YUJING , MA XIAO , CHEN FENG , HU XIAOHUI , Jin Song , He Xuefeng , Gao Jin , Zhu Baoli , Wu Depei , Qi Xiaofei 
Published: July 2020

Abstract
Background: Gastrointestinal (GI) tract graft-vs-host disease (GvHD) is a major cause of post-allo-HCT morbidity and mortality. Patients with steroid-refractory GI-GvHD face a poor prognosis and limited therapeutic options. Here, we report an interim analysis on the safety and efficacy of fecal microbiota transplantation (FMT) in treating steroid-refractory GI-GvHD.Methods: We did a non-randomized, open-label, phase 1 clinical study on patients with grade IV steroid-refractory GI-GvHD. FMT efficacy was evaluated using indexes of abdominal pain, diarrhea and bloody purulent stool at 14 and 21 days after the diagnosis of steroid-refractory GI-GvHD. The primary outcomes referred to clinical complete remission or partial remission. Secondary outcomes referred to EFS (event free survival) and OS (overall survival) at Day 90 and the end of the research. Safety was evaluated according to adverse events during FMT and the whole follow-up period. The study was registered with ClinicalTrials.gov as #NCT03148743.Results: A total of 56 patients with steroid-refractory GI-GvHD were enrolled. Of them, 24 patients with grade IV steroid-refractory GI-GvHD were assigned to FMT and 18 to the control group. The characteristics of the two group patients at baseline were similar. At Day 14 after FMT, 13 (54.2%) patients in FMT group and none (0%) of 18 control group achieved clinical remission (p<0.05), while 20(83%) patients in FMT group and 7(39%) in control group showed effective response (clinical remission+partial remission) (RR 7.86, 95% CI 1.88–32.9; p=0.005). At Day 21, the clinical remission was significantly greater in FMT group than in control group (14 (58.3%) of 24 vs 3(16%) of 18; RR 6.0, 95% CI 1.22–29.45; p=0.027). Within a follow up of 90 days, the FMT group showed better OS (HR, 7.0; 95% CI, 1.53-32.08; p=0.012). At the end of the research, the median survival time was >600 days in FMT group and 107 days in control group (HR, 4.73; 95% CI, 1.58-14.14; p=0.005). Both the EFS (HR, 0.24; 95% CI, 0.06-0.95; p=0.055) and OS (HR, 5.97; 95% CI, 1.52-23.43; p=0.01) kept increasing during the follow-up in FMT group. Overall, the mortality rate was lower in FMT group (HR, 5.97; 95% CI, 1.52-23.43; p=0.01). No difference was observed in the occurrence of other side effects, such as hemorrhagic cystitis, infection of bacteria & fungi, CMV&EBV, septicemia, TMA, cardiac events, thrombocytopenia and epilepsy.Conclusions: The diversity of intestinal microbiota can be affected by allo-HSCT. FMT is effective and safe in treating grade IV steroid refractory GI–GvHD.
Association Of Gut Microbiota During Early Pregnancy With Risk Of Incident Gestational Diabetes Mellitus: A Nested Case-Control Study
Authors: Hu Ping , Chen Xiuyi , Chu Xufeng , Fan Mengran , Ye Yi , Wang Yi , Han Maozhen , Yang Xue , Yuan Jiaying , Zha Li , Zhao Bin , Yang Chunxia , Qi Xiaorong , Ning Kang , Debelius Justin , Ye Weimin , Xiong Bo , Pan Xiongfei , Pan An 
Published: July 2020

Abstract
Background: We aimed to assess gut bacterial biomarkers during early pregnancy and subsequent risk of gestational diabetes mellitus (GDM) in Chinese pregnant women.Methods: Based on the Tongji-Shuangliu Birth Cohort study, we conducted a nested case-control study among 201 incident GDM cases and 201 matched controls individual matched on age, gestational week, and date of fecal sample collection. Fecal samples were collected during early pregnancy, and GDM was diagnosed at 24-28 weeks of pregnancy. Community DNA isolated from fecal samples and V3-V4 region of 16S rRNA gene amplicon libraries were sequenced. Results: In GDM cases versus controls, Rothia, Actinomyces, Bifidobacterium, Adlercreutzia, and Coriobacteriaceae, and Lachnospiraceae spp. were significantly reduced, while Enterobacteriaceae, Ruminococcaceae spp. and Veillonellaceae were over-represented. It was also found that the abundance of Staphylococcus relative to Clostridium, Roseburia and Coriobacteriaceae as reference microorganisms were positively correlated with fasting blood glucose, 1-h postprandial glucose, and 2-h postprandial glucose levels. Conditional Logistic regression showed that 4 microbial taxa during early pregnancy were associated with subsequent GDM risk, including Actinobacteria, Coriobacteriaceae, genus 26 of Coriobacteriaceae and an unknown specie of the Coprococcus.Conclusion: Gut microbiota during early pregnancy was associated with subsequent risk of GDM. Several beneficial and commensal gut microorganisms showed inverse relations with incident GDM, while opportunistic pathogenic members involving in GDM development, where they positively correlated with clinical measurements on OGTT. Our study provided promising biological markers that may be used in monitoring pregnant women’s health and developing therapeutic interventions on GDM at early stage of gestation.
A Qualitative Exploration Of Parents’ Experience And Perceptions Comparing Individual To Group Sports In Young People With Autism Spectrum Disorder.
Authors: Fondacaro Daniel Vella , Camilleri Nigel 
Published: July 2020

Abstract
Background: Young people (YP) with autism spectrum disorder (ASD) may prefer individual to group physical activity (PA). Levels of PA may differ with disorder severity and age. This study explores parents’ experiences with YP suffering from ASD when choosing between group and individual PA.Method: Retrospective case note reviews identified 701 new referrals received by the National Child and Young People’s Services, Malta, between 2016 to 2017. Of them, 24 received a diagnosis of ASD without co-morbidities and 10 were chosen via purposive random sampling. An 11-component semi-structured interview guide was created specifically for use in this study. Parents were interviewed and a thematic analysis was carried out.Results: Only one young person carried out PA which met the World Health Organisation recommendations. More parents (group only: n=3; 30%, both: n=6 ; 60%) preferred group PA for their children, while more YP (individual only: n=4; 40%, both: n=4 ; 40%) preferred individual PA. Parents described both group and individual PA having benefits. Most parents felt ‘misrepresented' and wanted to have more ASD-friendly sports facilities developed in for YP in Malta. Long hours of screen time was also a major parental concern. Younger age and more severe ASD were associated with higher levels of PA. Lower levels of PA, older age and milder ASD were associated with higher use of technology.Conclusion: This study reported on the parents’ perceptions on PA and discusses a possible link between ASD severity, PA, age and technological devices. The recommendations from this study are aimed at informing the development of sport services to be outsized as a form of therapy in Malta.
Movement Patterns of Atlantic Tarpon (Megalops atlanticus) in Brewers Bay, St. Thomas US Virgin Islands
Authors: Romero Mareike Donaji Duffing , Matley Jordan K. , Luo Jiangang , Ault Jerald S. , Pittman Simon J. , Nemeth Richard S. 
Published: July 2020

Abstract
Background Atlantic tarpon (Megalops atlanticus) are highly migratory species ranging along continental and insular coastlines of the Atlantic Ocean. Despite broad geographic distribution and importance as recreational fisheries, little is known about space-use patterns of tarpon within the Eastern Caribbean. Acoustic telemetry was used to track tarpon (n=14, 61- 95cm-FL) from September 2015 to February 2018 in St. Thomas, U.S. Virgin Islands to understand horizontal and vertical movements during diel, crepuscular and seasonal periods and under different environmental conditions. ResultsEight tarpon were transient while four had >80% residency and average activity space of 0.76 km2 (range = 0.075-1.174 km2) within a small (~1.8km2) bay. Tarpon occurred in <18 m depth with occasional movements to deeper water, including during hurricanes. Activity was greater during day compared to night, with peaks during crepuscular periods. During the day tarpon primarily utilized the waters along the St. Thomas airport and at night tarpon typically remained in a small shallow lagoon. However, when temperatures in the lagoon exceeded 30 °C, tarpon moved to cooler, deeper waters outside the lagoon. ConclusionThis study showed distinct and mostly non-overlapping home ranges except when seasonally abundant food sources were present and provided a unique perspective on the effects of extreme environmental conditions on tarpon movement and habitat use. These metrics are useful for management of tarpon, particularly under changing climatic conditions.
Cognitive training in fully immersive virtual reality improves visuospatial function and fronto-occipital functional connectivity in a pre-dementia state: A randomized controlled trial
Authors: Kang Jae Myeong , Kim Nambeom , Lee Sook Young , Woo Soo Kyun , Yeon Byeong Kil , Lee Jun-Young , Youn Jung-Hae , Ryu Seung-Ho , Cho Seong-Jin 
Published: July 2020

Abstract
BackgroundCognitive training has potential in staving off cognitive decline. Recent studies using semi-immersive virtual reality (VR)-assisted cognitive training have shown inconsistent results. We aimed to test the hypothesis that cognitive training using fully immersive VR, which may facilitate visuospatial process, would improve visuospatial function, comprehensive neuropsychological functions, psychiatric symptoms, and functional connectivity (FC) of the visual network in the resting brain in pre-dementia state.MethodsParticipants with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) were randomly assigned to a VR (n = 23) or a control group (n = 18). VR group participants received multi-domain cognitive training in a fully immersive VR environment twice a week for one month. Both groups were evaluated for cognitive function using comprehensive neuropsychological tests including the Rey-Osterrieth Complex Figure Test (RCFT) copy task, for psychiatric symptoms using the Geriatric Depression Scale, Positive and Negative Affect Schedule-positive affect (PANAS), Apathy Evaluation Scale (AES), and Quality of Life-Alzheimer’s disease, as well as resting-state functional magnetic resonance imaging (rsfMRI) at baseline and post-training. Repeated measures analyses of variance were used to compare the effect of the cognitive training between the groups. Seed-to-voxel based analyses were used to find the cognitive improvement-related FC in the visual network of the brain.ResultsAfter VR cognitive training, the VR group showed improvements in the RCFT copy task (F = 15.44, p < 0.001), the PANAS-positive (F = 8.28, p < 0.001), and the AES (F = 21.28, p = 0.006) compared to the control group. rsfMRI revealed that improvement in the RCFT copy task was associated with frontal-occipital FC increase in the VR group compared to the control group.Conclusions and relevanceFully immersive VR cognitive training had positive effects on visuospatial function, positive affect, apathy, and frontal-occipital FC in older adults at pre-dementia state. Future trials using VR cognitive training with larger sample sizes and more sophisticated design over a longer duration may observe greater improvements in cognition, psychiatric symptoms, and brain FC.Trial registrationClinical Research Information Service, conforming to the World Health Organization International Clinical Trials Registry Platform (WHO-ICTRP), KCT0005243. Registered 22 July 2020 – retrospectively registered, https://cris.nih.go.kr/cris/search/search_result_st01_en.jsp?seq=17055&ltype=&rtype=
COVID-19 Pandemic: Home Confinement Problems and Mental Health
Authors: Parrado-González Alberto , León-Jiménez Victor , León-Jariego José C. 
Published: July 2020

Abstract
Home confinement during the COVID-19 crisis causes problems in everyday life that can affect people's mental health. In this context, the purpose of this study was (1) to identify the most frequent problems experienced during the home confinement, (2) to analyse whether these problems vary according to socio-demographics; and (3) to study the influence of home confinement on mental health. One thousand five hundred sixty-nine participants living in Spain during the COVID-19 lockdown answered an online survey including questions about socio-demographics, problems of home confinement and mental health. We used factor analysis to group the home confinement problems into identifiable categories. Descriptive and inferential statistical methods for comparison between socio-demographics were used, and the influence of subsets of home confinement problems on mental health was analysed by multiple linear regression.The 16 evaluated problems were grouped into three factors: “Anger and Frustration”, “Deprivation of Social Contact”, and “Living Together Issues”. The most frequent problem was “missing somebody”, while “being afraid of going mad” was the least frequent one. Women, young people, people with less space at home, and teleworkers and non-working people during the lockdown period reported more home confinement problems. The Anger and Frustration factor was the one most related to mental health. These results highlighted the problems that people had to face during home confinement and their influence on mental health. Finally, the paper suggests designing specific strategies to cope with these problems according to participants’ socio-demographics.
Competitive adsorption geometries for the arsenate As(V) and phosphate P(V) oxyanions on magnetite surfaces: Experiments and theory
Authors: Liang Xiaoliang , Lin Xiaoju , Wei Gaoling , Ma Lingya , He Hongping , Santos-Carballal David , Zhu Jianxi , Zhu Runliang , De Leeuw Nora H. 
Published: July 2020

Abstract
In the present study, the competitive adsorption geometries for arsenate and phosphate on magnetite surfaces over a pH range of 4–9 were investigated using in situ attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) and two-dimensional correlation analysis (2D-COS). The adsorption energies and infrared vibrational frequencies of these surface complexes were also calculated by first-principles simulations. Arsenate and phosphate have different preferences for the magnetite surface in the presence of aqueous solvent at both acid and alkaline pH. For the adsorption of phosphate, mono-protonated monodentate mononuclear (MMM) complexes dominated at acid pH, while non-protonated bidentate binuclear (NBB) complexes were dominant at alkaline pH. Arsenate mainly formed bidentate binuclear (BB) complexes with some outer-sphere species, both of which were more prevalent at acid pH. The pre-absorbed inner-sphere arsenate species were scarcely affected by the introduction of phosphate. However, the pre-absorbed phosphate oxyanions, especially the MMM complexes, were significantly substituted by BB arsenate at the magnetite surfaces. The adsorption affinity of phosphate and arsenate species for magnetite surface was found to increase in the following order: MMM phosphate complex &lt; NBB phosphate complex &lt; BB arsenate complex, which was consistent with the calculated adsorption energies. The simulated infrared vibrational frequencies for the most favorable adsorption modes of each oxyanion display distinctive patterns, and their trends are in excellent agreement with experimental data.
The effects of pH, adsorption sequence, and mineral species on the competitive adsorption between arsenate and phosphate oxyanions are also discussed, and their different competing ability and stability on the magnetite surfaces can be ascribed to the variations in adsorption geometry and strength of binding. To the best of our knowledge, this is the first study aiming to distinguish the stability of the different phosphate and arsenate complexes on magnetite by employing a combined approach of in situ spectroscopy and DFT simulations. Our results provide molecular-level insight into the geometries and relative stabilities of the adsorption of phosphate and arsenate on magnetite surfaces, which is useful for interpretation of the mobility and bioavailability of these anions.
Crystal structures of K-cymrite and kokchetavite from single-crystal X-ray diffraction
Authors: Romanenko Alexandr V. , Rashchenko Sergey V. , Sokol Alexander G. , Korsakov Andrey V. , Seryotkin Yurii V. , Glazyrin Konstantin V. , Musiyachenko Kira 
Published: July 2020

Abstract
We determined for the first time the crystal structures of high-pressure K-cymrite (KAlSi3O8⋅H2O) and its dehydrated form kokchetavite (KAlSi3O8) using single-crystal X-ray diffraction. The K-cymrite structure has been successfully refined in the hexagonal space group P6/mmm [a = 5.3361(3) Å, c = 7.7081(7) Å, V = 190.08(3) Å3, R1 = 0.036 for 127 unique observed reflections], which is in agreement with previous models from powder X-ray diffraction. In contrast, kokchetavite shows superstructural reflections, suggesting a different unit cell and a space group of P6/mcc [a = 10.5757(3) Å, c = 15.6404(6) Å, V = 1514.94(10) Å3, R1 = 0.068 for 1455 unique observed reflections]. Upon dehydration, single-crystal grains of K-cymrite transform into single-crystal grains of kokchetavite. The latter questions a previous interpretation of kokchetavite crystals in mineral inclusions as a product of direct crystallization from fluid/melt. The Raman spectrum of K-cymrite shows a strong polarization dependence, which is important in identification of the mineral inclusions.
Toward Maintaining the Identification and Architectural Heritage to Develop the Historical Areas in Ain Al-Sira
Authors: Shokry Omnia Ibrahim , Khalifa Mahmoud Mohamed , Abdel Shaima Nabil 
Published: July 2020

Despite the State’s exerted efforts in preserving Egyptian monuments as tourist destinations, Ain Al-Sira area has been suffering from multiple problems. The modern construction arts within the historical area and its architectural heritage have been ignored, as well as the construction of contemporary residential buildings not related to the historical area. The purpose of the research is to develop the architectural heritage of the residential neighborhoods in Ain Al-Sira in line with the architectural facades of the ancient historical monuments with a view to the restoration of these monuments, which have changed their faces and their architectural efficiency due to their obsolescence, weather and time factors and overcoming the scarcity of maintenance and restoration works. The new research includes the development of interim strategies in the implementation of the restoration and development of monuments and architectural style of residential neighborhoods in the area of Ain Al-Sira.The motive of the research was the existence of a problem in the current local architectural formations, which is the lack of integration and harmony of ancient monuments with new neighborhoods and the imbalance between them. The descriptive and analytical approach has been followed to clarify existing effects and what is required to be developed The research dealt with the analysis and presentation of the importance and the historical background of the area of Ain Al-Sira, with its ancient monuments, that we came to the current residential and architectural form between the shape of ancient monuments and modern dwellings, as well as the presentation of architectural problems in the region. To propose appropriate solutions for the development of the region in accordance with local and international standards and laws in order to find the most appropriate methods for architectural processing and the research will contain: On the proposals and plans necessary to develop the architectural style between the old and modern in the area of Ain El – Sira .