bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensemble Flash Flood Predictions Using a High-Resolution Nationwide Distributed Rainfall-Runoff Model: Case Study of the Heavy Rain Event of July 2018 and Typhoon Hagibis in 2019
Authors: Sayama Takahiro , Yamada Masafumi , Sugawara Yoshito , Yamazaki Dai 
Published: July 2020

Abstract
The heavy rain event of July 2018 and Typhoon Hagibis in October 2019 caused severe flash flood disasters in numerous parts of western and eastern Japan. Flash floods need to be predicted over a wide range with long forecasting lead time for effective evacuation. The predictability of flash floods caused by the two extreme events are investigated by using a high-resolution (~ 150 m) nationwide distributed rainfall-runoff model forced by ensemble precipitation forecasts with 39-h lead time. Results of the deterministic simulation at nowcasting mode with radar and gauge composite rainfall could reasonably simulate the storm runoff hydrographs at many dam reservoirs over western Japan for the case of heavy rainfall in 2018 (F18) with the default parameter setting. For the case of Typhoon Hagibis in 2019 (T19), a similar performance was obtained by incorporating unsaturated flow effect in the model applied to Kanto region. The performance of the ensemble forecast was evaluated based on the bias scores and the relative operating characteristic curves, which suggested the higher predictability in peak runoff for T19. For the F18, the uncertainty arises due to the difficulty in accurately forecasting the storm positions by the frontal zone; as a result, the actual distribution of the peak runoff could not be well forecasted. Overall, this study showed that the predictability of flash floods was different between the two extreme events. The ensemble spreads contain quantitative information of predictive uncertainty, which can be utilized for the decision making of emergency responses against flash floods.
Identification of AAV serotypes for lung gene therapy in human embryonic stem cell derived lung organoids.
Authors: Meyer-Berg Helena , Yang Lucia Zhou , de Lucas María Pilar , Zambrano Alberto , Hyde Stephen C. , Gill Deborah R. 
Published: July 2020

Abstract
Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral-vector for gene delivery with multiple natural and artificial serotypes available displaying alternate cell, tissue and species-specific tropisms. Efficient AAV serotypes for the transduction of the conducting airways have been identified for several species; however, efficient serotypes for human lung parenchyma have not yet been identified. Here, we screened the ability of multiple AAV serotypes to transduce lung bud organoids (LBOs) - a model of human lung parenchyma generated from human embryonic stem cells. Microinjection of LBOs allowed us to model transduction from the luminal surface, similar to dosing via vector inhalation. We identified the natural rAAV2 and rAAV6 serotypes, along with synthetic rAAV6 variants, as having tropism for the human lung parenchyma. Positive staining of LBOs for surfactant proteins B and C confirmed distal lung identity and suggested the suitability of these vectors for the transduction of alveolar type II cells. Our findings establish LBOs as a new model for pulmonary gene therapy and stress the relevance of LBOs as a viral infection model of the lung parenchyma as relevant in SARS-CoV-2 research.
Successful management of a case of SARS‐CoV‐2 infection in an advanced Rheumatoid Arthritis patient by dose reduction of immunosuppressive medication
Authors: Bazmjoo Ahmadreza , Bagherzadeh Mohammad Aref , Farahmandpoor Farida , Raoofi Rahim , Abdoli Amir 
Published: July 2020

Abstract
Rheumatoid Arthritis (RA) patients usually managed with immunosuppressive agents and they are at a higher risk of infections. There are limited data regarding RA patients with COVID-19. This article reports a RA patient with an acute SARS‐CoV‐2 infection that successfully managed by dose reduction of immunosuppressive medication.
Successful management of the first case of SARS‐CoV‐2 infection in an Iranian HIV patient
Authors: Raoofi Rahim , Bagherzadeh Mohammad Aref , Bazmjoo Ahmadreza , Shakeri Heshmatollah , Abbasi Alireza , Abdoli Amir 
Published: July 2020

Abstract
There are limited data regarding HIV/AIDS associated-COVID-19 infection. This article reports a case of HIV female with an acute SARS‐CoV‐2 infection that successfully managed and treated in Iran. This study presents the clinical symptoms, diagnosis, and treatment of this case.
The presentation of spontaneous splenic rupture in a COVID-19 patient: a case report
Authors: Mobayen Mohammadreza , Yousefi Saeed , Mousavi Mohammadsadegh , Anbaran Amin Shafighi 
Published: July 2020

Abstract
Introduction: Splenic rupture is an emergency condition and the vast numbers of cases are secondary to trauma. Several underlying pathologies have also been associated with splenic rupture, such as hematological diseases, malignancies, and infectious and inflammatory diseases.Presentation of case: The patient was a 52-year-old man who referred to the Poursina Hospital in Rasht while complaining of abdominal pain from the day before hospitalization. The patient reported a history of lethargy, fever, and nausea. In the examinations performed, there was a brief tenderness in the patient's epigastrium. The patient was monitored and about 12 hours after hospitalization, ill appearance, respiratory (respiratory distress) symptoms, and high fever were reported for the patient. According to the examination, the patient was immediately transferred to the operating room and underwent laparotomy. During the operation, contrary to our expectations, a lot of blood (about 1000 cc) was observed in the patient's abdomen. After blood suctioning, the left upper quadrant (LUQ) was bleeding and the rupture of the spleen could also be observed. Therefore, a splenectomy was performed .In the examinations performed for the patient, the patient's rtPCR test confirmed COVID-19.Conclusion: The evaluation of the spontaneous splenic rupture (SSR) in our case shows that this type of risk should also be considered in patients with COVID-19 who referred to medical centers with abdominal pain, and if more cases are reported, the correctness of this process can be commented on.
Contrasting compositions between phenocrystic and xenocrystic olivines in the Cenozoic basalts from central Mongolia: Constraints on source lithology and regional uplift
Authors: Zhang Yunying , Yuan Chao , Sun Min , Huang Zongying , Narantsetseg Tserendash , Ren Zhongyuan , Li Pengfei , Zhang Qinglin 
Published: July 2020

AbstractTwo Cenozoic prominent features are spatio-temporally associated in central Mongolia, i.e., the continental basalts and regional uplift, but their genesis and relationship remain unclear. This study presents major- and trace-element compositions for olivine phenocrysts and xenocrysts, as well as data of bulk-rock geochemistry and Sr-Nd-Hf isotopes for the host basalts. The studied basalts mostly have trachybasalt compositions with high total alkali (Na2O + K2O = 5.1–8.2 wt%) contents and all display OIB-like trace element patterns (e.g., spikes of Ba, Nb, and Ta and troughs of Th and U) and EM1-like Sr-Nd-Hf isotopic compositions. Compared to the partial melting products of mantle peridotite, these basaltic samples have higher FeO/MnO, Zn/Mn, and Zn/Fe ratios. Meanwhile, phenocrystic olivines are characterized by lower Ca, Mn, Mn/Zn, and Mn/Fe but higher Ni than their counterparts in the peridotitic melts, indicating a pyroxenite-rich mantle source. The above geochemical data suggest that the source of the studied basalts was mainly made up of secondary pyroxenite produced by the reaction of recycled oceanic crust with its ambient mantle peridotite. The calculated magma oxygen fugacities (ΔFMQ-0.26 to +0.42) and mantle melting temperatures (1343–1430 °C) do not support a genetic link with the stagnant Pacific slab or with a deep mantle plume. Instead, the far-field effect of India-Eurasia convergence possibly tapped the upper asthenospheric mantle, subsequent melting of which gave rise to the dispersive Cenozoic basalts. On the other hand, the xenocrystic olivines exhibit zoned textures with high-Fo (up to 92) cores and low-Fo (down to 76) rims, reflecting the melt-rock interaction. Preservation of zoned olivine xenocrysts indicates rapid magma ascent and widespread melt-rock reaction in the mantle lithosphere, which may modify the rheology and accelerate the mechanical erosion of mantle lithosphere. Consequently, mass deficit in the lithosphere could have caused isostatic uplift of central Mongolia in the Cenozoic.
Drinking water treatment and chemical well clogging by iron(II) oxidation and hydrous ferric oxide (HFO) precipitation
Authors: van Beek C. G. E. M. , Hofman-Caris C. H. M. , Zweere G. J. 
Published: July 2020

Abstract
Removal of iron(II) from groundwater by aeration and rapid sand filtration (RSF) with the accompanying production of drinking water sludge in the preparation of drinking water from groundwater, and chemical well clogging by accumulation of hydrous ferric oxide (HFO) precipitates and biomass after mixing of oxygen containing and of iron(II) containing groundwater, are identical processes. Iron(II) may precipitate from (ground)water by homogeneous, heterogeneous and/or biological oxidation, where the contribution of these processes, and thus the characteristics of the corresponding HFO precipitates, is a function of pH and process-conditions. Under current conditions in drinking water treatment, homogeneous oxidation dominates above pH ≈ 7.75, and heterogeneous and biological oxidation below this value. In chemical well clogging, this transition occurs at pH ≈ 7.0. This information is relevant for the optimization of removal of iron(II) from groundwater by aeration and RSF and the corresponding quality of the produced drinking water sludge, and for the operation of wells clogging by accumulation of HFO precipitates and biomass.
Road From Nose to Brain for Treatment of Alzheimer: The Bumps and Humps
Authors: Kumar Rajesh , Gulati Monica , Singh Sachin Kumar , Sharma Deepika , Porwal Omji 
Published: July 2020

:
Vulnerability of the brain milieu to even the subtle changes in its normal physiology is guarded by a highly efficient blood
brain barrier. A number of factors i.e. molecular weight of the drug, its route of administration, lipophilic character etc. play a significant
role in its sojourn through the blood brain barrier (BBB) and limit the movement of drug into brain tissue through BBB. To overcome
these problems, alternative routes of drug administration have been explored to target the drugs to brain tissue. Nasal route has been
widely reported for the administration of drugs for treatment of Alzheimer. In this innovative approach, the challenge of BBB is bypassed. Through this route, both the larger as well as polar molecules can be made to reach the brain tissues. Generally, these systems
are either pH dependent or temperature dependent.

Results:
The present review highlights the anatomy of nose, mechanisms of drug delivery from nose to brain, critical factors in the
formulation of nasal drug delivery system, nasal formulations of various drugs that have been tried for their nasal delivery for treatment
of Alzheimer.

Conclusion:
It also dives deep to understand the factors that contribute to the success of such formulations to carve out a direction for
this niche area to be explored further.
Design of Psk Based Trusted Dtls for Smart Sensor Nodes
Authors: Yadav Anil , Pandey Sujata , Singh Rajat , Rakesh Nitin 
Published: July 2020

Background:
RSA based key exchange is a heavy and time-consuming process, as it involves numerous
message exchange between a client and the server. Pre-shared key (PSK) based handshake process attempts to reduce the
messages while the key exchange between a client and the server.

Method:
This paper extends the TEE enabled dtls handshake design based on RSA to the TEE enabled pre-shared key
based handshake. A dtls client and the server installs the pre-shared key in advanced so that the message exchanges can be
reduced while session key generation.

Result:
In this article, the authors have significantly reduced this penalty by fine-tuning of the tdtls algorithm for psk
based handshake. On average, this gain is over 2 ms (50% - from 3.5 ms to 1.5 ms) across various cipher-suites.

Conclusion:
The tdtls approach increases the security of the session key and its intermediate keying materials which is a
huge gain as compared to minor handshake time increase. The algorithm ensures an end-to-end security to the PSK based
session key as well as its keying materials between a dtls client and a server.
Hubungan Aktivitas Fisik dan Kekuatan Massa Otot dengan Kadar Gula Darah Sewaktu
Authors: Nurman Kathleen , Nur Edri Indah Yuliza , Khasanah Tri Ardianti 
Published: July 2020

Abstrak Aktivitas fisik merupakan salah satu pilar pelaksanaan penanganan pasien diabetes mellitus. Pasien diabetes cenderung memiliki kekuatan massa otot dan fungsi tangan yang menurun yang dapat berakibat pada menurunnya kualitas hidup. Tujuan penelitian ini adalah mengetahui hubungan aktivitas fisik dan kekuatan massa otot terhadap kadar glukosa darah sewaktu pada pasien diabetes mellitus tipe 2. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan observasional dan desain cross-sectional melibatkan 77 responden terdiagnosa diabetes mellitus tipe 2 berusia 18-60 tahun diwawancara mengenai aktivitas fisik menggunakan International Physical Activity Questionnare serta pengukuran kekuatan massa otot menggunakan hand dynamometer dan kadar gula darah sewaktu (GDS) menggunakan alat pengukur glukosa darah. Kadar GDS responden didominasi oleh kategori GDS tinggi yaitu 55 orang (71,4%), kategori kekuatan massa otot lemah memiliki persentase terbanyak yaitu 40 orang (51,9%), dan aktivitas fisik sedang sebanyak 46 orang (59,7%). Terdapat hubungan antara aktivitas fisik dan kekuatan massa otot dengan kadar gula darah sewaktu pasien diabetes mellitus tipe 2.Â Kata kunci: aktivitas fisik, kekuatan massa otot, gula darah sewaktu, diabetes mellitusAbstractPhysical activity is one of the most important interventions for patients with diabetes mellitus. Patients with this metabolic disease tend to have lower skeletal muscle strength that results in lower quality of life. This study aimed to examine the relation of physical activity and skeletal muscle strength on blood glucose level of type 2 diabetes mellitus patients. This study was an analytic observational study. The research subjects were 77 patients with type 2 diabetes mellitus aged 18-60 years old. Interviews were conducted on their physical activity habits using the International Physical Activity Questionnaire. Handgrip strength was measured using hand dynamometer, while the rapid blood glucose was measured using a blood glucose monitoring device. Most prevalent blood glucose level category in this study was â€œhighâ€ with 71.4% of respondents, 51.9% of respondents had low skeletal muscle strength, and 59.7% of respondents had moderate physical activity level. There is a significant relationship between physical activity and skeletal muscle strength of patients with type 2 diabetes mellitus blood glucose levels. Keywords: physical activity, skeletal muscle strength, blood glucose level, diabetes mellitus
A Original Article ANALGESIC ACTIVITY OF BARK AND LEAVES OF FICUS RELIGIOSA L. FROM NEPAL
Authors: MARASINI DHARMA RAJ , PANDEY JITENDRA , SHARMA LAXMAN PAUDEL , PAUDEL LAXMI , GYAWALI ROSHNI , ROKAYA RABINDRA KUMAR , GIRI PARAS MANI , KHADKA RAM BAHADUR , ARYAL PRAMOD , BHANDARI RAVIN 
Published: July 2020

Objective: Because of adverse side effects, caused by NSAIDs, tolerance, and dependence induced by opiates, the use of these analgesic agents has not been successful in all cases. Therefore, alternative analgesic drugs from plant sources are the new target now days. The objective of this study was to evaluate the analgesic activity of ethanolic extracts of stem barks and leaves of Ficus religiosa.
Methods: The analgesic activity of ethanolic extract of stem barks and leaves was evaluated in the Swiss albino mice model using acetic acid-induced writing response and Eddy’s hot plate method. Analgesic activity was demonstrated with the percentage inhibition of acetic acid induced writings and the percentage increased in latency time of paw licking. The potency of test extracts was compared with standard drug, Diclofenac.
Results: Ethanolic extract of leaves and bark of F. religiosa showed potential analgesic activity from both methods. From Eddy’s hot plate model, it was observed that the percentage of increased latency time at 90 min by ethanolic extract of leaves and stem bark was found to be 70.81 % (8.54 min) and 70.78 % (8.53 min) respectively at a dose of 400 mg/kg. Both of these results are statistically significant (p<0.05) as compared to the test group. Furthermore, both of these extracts showed the dose-dependent and time-dependent increased in latency time and these results are compared to that of standard drug Diclofenac. Similarly, ethanolic extract of leaves and stem at 400 mg/kg significantly inhibited the number of writhings induced by acetic acid. The percentage inhibition of writhings by ethanolic extract of leaves at a dose of 400 mg/kg was 68.47 % which was similar to that of standard drug Diclofenac (68.47 %). However, ethanolic extract of bark showed relatively lower percentage inhibition (60.79 %) as compared to leaf extract and standard, but the result was significant as compared to that of the test group (p<0.05).
Conclusion: Ethanolic extracts of F. religiosa stem bark and leaf possess both central and peripheral analgesic properties and these effects may be beneficial for the management of pain.
High-concentration nonavian high-molecular weight hyaluronan injections and time-to-total knee replacement surgery
Authors: Etter Katherine , Chitnis Abhishek S , Holy Chantal E , Gray F Scott , Manalac Fernando J , Bisson Brad , Bhattacharyya Samir K 
Published: July 2020

Aim:
To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections.
Materials & methods:
Using MarketScan
®
Commercial claims all patients aged 18–64 who underwent TKR surgery between 2008 and 2017 were identified. Time-to-TKR surgery was compared between patients receiving Orthovisc
®
(Anika Therapeutics Inc. Bedford MA, USA, referred to as nonavian HMW-HA) injections and patients who did not receive an HA injection.
Results:
The median time-to-TKR surgery was 893 days in the nonavian HMW-HA cohort and 399 days in the non-HA cohort (p < 0.001), a difference of 494 days (16.2 months).
Conclusion:
This study demonstrates that the time-to-TKR surgery is 16.2 months longer in patients who received treatment with nonavian HMW-HA injections.
Pengaruh Penyuluhan Kesehatan Tentang Pengisian Buku Kia Oleh Ibu Terhadap Stimulasi Dan Perkembangan Anak Usi 0-3 Tahun Di Puskesmas Tambak Pulau Bawean-Gresik
Authors: Umiyah Astik , Irwanto Irwanto , Purnomo Windhu 
Published: July 2020

One factor inﬂ uencing children development is mother’s knowledge concerning the actual process of child development. Health counseling to the mother is one option to maintain the children’s health, as well as to monitor their development. This study was to analyze the inﬂ uence of health counseling concerning mothers’ practice in ﬁ lling mother and child health book towards stimulation and development in children aged 0-3 years in Tambak Health Center, Bawean Island, Gresik Regency. This applied quasi-experimental pretest - posttest group design, with provision of health counseling as intervention. This study was conducted in Tambak Health Center at Bawean Island for 3 months, with overall sample consisted of 60 mothers with children aged 0-3 years, divided into 30 each in the treatment and the control groups. Questionnaires were utilized and analysis was done using the Mann-Whitney Test. The results indicated signiﬁ cant value of p (p> 0.05) meaning that stimulation provided no diﬀ erence between the treatment and control groups, but a downward trend occurred every month, with the ﬁ rst month (p = 0.937), the second month (p = 0.289) and the third month (p = 0.213) On the other hand, development provided the inﬂ uence with value of p <0.05. Counseling on ﬁ lling up MCH book can improve mother’s ability to stimulate the development of children aged 0-3 years and mother can provide stimulation at every stage of child development through MCH book.
Abstrak
Salah satu faktor yang memengaruhi perkembangan anak adalah ketidaktahuan ibu tentang proses perkembangan anak sesungguhnya, penyuluhan kesehatan kepada ibu merupakan salah satu cara untuk bagaimana menjaga kesehatan anak dan cara pemantauan perkembangan. Tujuan penelitian ini adalah menganalisis pengaruh penyuluhan kesehatan tentang pengisian BuKu KIA terhadap stimulasi dan perkembangan pada anak usia 0-3 Tahun di Puskesmas Tambak Pulau Bawean-Kab.Gresik. Penelitian ini menggunakan quasi eksperimen pretest post test group design, intervensi yang diberikan berupa pemberian penyuluhan kesehatan. Penelitian ini dilakukan di Puskesmas Tambak Pulau Bawean selama 3 bulan, keseluruhan sampel berjumlah 60 ibu yang terdiri dari kelompok perlakuan dan kelompok kontrol masing-masing 30 ibu yang mempunyai anak usia 0-3 tahun. Instrumen menggunakan kuesioner dan analisis data menggunakan uji MannWhitney. Hasil uji statistik nilai signiﬁ kan (p> 0,05) arti bahwa stimulasi tidak ada perbedaan antar kelompok perlakuan dan kontrol, tetapi ada penurunan tren tiap bulan yang terjadi yaitu bulan pertama (p=0,937), bulan kedua (p=0,289),dan bulan ketiga (p=0,213). Sedangkan perkembangan ada pengaruh (p< 0,05). Pemberian penyuluhan kesehatan tentang pengisian Buku KIA oleh ibu dapat meningkatkan kemampuan ibu dalam menstimulasi perkembangan anak usia 0-3 tahun dan ibu dapat memberikan stimulasi di setiap tahapan usia perkembangan anak melalui Buku KIA.