bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supra-auricular and post-auricular resection of pre-auricular and post-auricular sinuses
Authors: Ding H , Xie H , Qiao F , Wang T , Huang X , Ning Q 
Published: October 2019

AbstractObjectiveThis study aimed to classify the pre-auricular sinus before performing radical dissection, so as to achieve optimal aesthetic results.MethodsThe recent five-year clinical data of 53 patients with a congenital pre-auricular sinus and infection treated in the hospital were reviewed. According to the sinus course, pre-auricular and post-auricular types were defined, and regional dissection was performed using the modified supra-auricular or post-auricular approach.ResultsAll patients achieved primary intention healing of the incision, and were followed up for six months to five years. No recurrence was found, and the incision scar was completely concealed.ConclusionSurgical approaches for regional dissection might be adopted based on the different types of pre-auricular sinuses, and further radical dissection might be performed to achieve optimal aesthetic results.
The Politics of Popular Coalitions: Unions and Territorial Social Movements in Post-Neoliberal Latin America (2000–15)
Authors: Etchemendy Sebastián 
Published: October 2019

AbstractAt a general level of neoliberal repudiation or expansion of social policies, most post-neoliberal Latin American governments in the 2000s have exhibited similarities. However, coalitions with popular actors have displayed a lot of variation. In order to compare popular-sector coalitions the article constructs a framework with two central dimensions: electoral and organisational/interest; in post-import substitution industrialisation (ISI) Latin America the latter is composed of both unions and territorial social movements (TSMs). It contends that the region witnessed four types of popular coalitions: electoral (Ecuador and Chile), TSM-based (i.e. made up of informal sector-based organisations, Venezuela and Bolivia), dual (i.e. composed of both unions and TSMs, Argentina and Brazil) and union/party-based (Uruguay). The study argues that government–union coalitions are largely accounted for by the relative size of the formal economy, and by the institutional legacies of labour based-parties. Coalitions with informal sector-based organisations are rooted in the political activation of these TSMs during the anti-neoliberal struggles of the 1990s and early 2000s.
It hurts but I still need it: a qualitative investigation of post-event processing in social anxiety disorder
Authors: Yoshinaga Naoki , Takaoka Kota , Kobori Osamu 
Published: October 2019

AbstractBackground:It has been proposed that both positive and negative metacognitive beliefs sustain engagement in post-event processing (PEP). However, it is unknown: (1) whether individuals with social anxiety disorder (SAD) actually derive the benefits from PEP that they expect; (2) if this is not the case, how their positive beliefs are maintained; and (3) if they are aware of the counterproductive effects of PEP, why they still perform PEP.Aims:To explore the phenomenology of the processes involved in PEP from the perspective of SADs, in order to address the research questions above.Method:Twenty-one participants suffering from SAD received individual semi-structured interviews. Transcripts were analysed using thematic analysis.Results:Analysis revealed three main themes: (1) ‘Only, safe and useful way to improve myself’: SADs feel the need to improve their social performance, and they believe that PEP is the only, safe, and private way to do so, which is an underlying motive for them to do PEP; (2) ‘It hurts more than helps me’: however, through PEP, they do not seem to obtain the benefit that they expect, or only find a variety of counterproductive outcomes; (3) ‘Better safe than sorry’: they sometimes find makeshift solutions to improve their social performance during PEP, which may maintain their PEP as a form of intermittent reinforcement. They weigh up such costs and benefits, and choose to perform PEP while feeling conflicted about PEP.Conclusions:The results suggest that: (1) SADs rarely obtain the benefits from PEP that they expect; (2) their positive metacognitive beliefs are maintained by solutions they sometimes find during PEP; and (3) SADs choose to perform PEP while feeling conflicted; while PEP ironically maintains and exacerbates negative self-beliefs/images, it is the only safe and useful way to improve their social performance. These findings support and expand on the theories of PEP.
Art history and the global: deconstructing the latest canonical narrative
Authors: Joyeux-Prunel Béatrice 
Published: October 2019

AbstractThis article reconsiders the breakthrough of global approaches to art history within a broader historical, sociological, and institutional context. It also puts into perspective the interdisciplinary openness of global-oriented approaches, and their impact in the discipline. Aiming at historicizing them up to the present, it questions the notion that the origins of global thinking in art history are to be found in the 1980s with the so-called postcolonial turn among art historians, which has become the canonical narrative. Postcolonial awareness emerged very late among art historians, only in the early 2000s. This contrasted, however, with a long-standing interest in non-Western artefacts and visual cultures among certain art historians, who were also interested in global comparisons and transdisciplinary approaches. These scholars borrowed from other fields such as history, anthropology, philosophy, and psychology, but their work was gradually put aside in the process of building art history as a discipline. This article will try to explain why this happened, and will also argue that the globalization of the art market played a greater role than postcolonial theory in encouraging art historians to adopt a globalized approach.
Party-Determined Viability and Gender Bias in Open-List Proportional Representation Systems
Authors: Ragauskas Rimvydas 
Published: October 2019

AbstractUsing individual-level data from three Lithuanian legislative elections (2008, 2012, 2016), this article investigates voter bias in an open-list proportional representation system in which parties rank candidates but voters are able to fully influence the rank order through preferential voting. This study examines the average effects of and variation in gender bias among voters of different parties. Most importantly, it also investigates how party cues interact with gender cues—that is, whether discriminatory tendencies vary by a candidate's party-determined viability. After establishing that there is no evidence of elite bias in favor of or against women candidates, with the exception of the Social Democrats and a few other parties, I demonstrate that, on average, female Lithuanian politicians receive approximately 7% fewer preferential votes than their male counterparts. In addition, the models predict that gender bias is most pronounced against the female candidates who are best placed to enter parliament. Finally, I demonstrate that Social Democratic voters are, on average, the most undisposed toward female candidates, correcting for positive elite bias toward female candidates from the Lithuanian Social Democratic Party, while voters of the Homeland Union party (conservatives) strongly prefer women politicians.
Relating Observations of Gradient Nonbalance at the Top of Hurricanes With Their Warm Core Structures
Authors: Cohen Yair , Durden Stephen L. , Harnik Nili , Heifetz Eyal 
Published: October 2019

AbstractRecent analysis of Weather Research and Forecasting simulations shows that the flow around high‐pressure regions that often develop at the top of Hurricanes (15‐km altitude) violates the gradient wind balance, hence termed as “gradient nonbalance.” While observations at such high altitudes are rare, recently, NASA‐HS3 and the Office of Naval Research‐Tropical Cyclone Intensity campaigns deployed dropsondes from unprecedented levels around 18 km. In this work we use a wavenumber decomposition method to reproduce 2‐D slices and 3‐D structures from three storms from these campaigns: Edouard (2014), Joaquin (2015), and Patricia (2015). The analyzed data show that the development of high pressure at the hurricane's top leads to various degrees of gradient nonbalance. These highs are a hydrostatic reflection of the storm tilt, which offsets the warm core with respect to the near surface low and the slanted eyewall. The implications of these findings and the relations with recent reports of upper‐level wind field are discussed.
Detecting the State of the Climate System via Artificial Intelligence to Improve Seasonal Forecasts and Inform Reservoir Operations
Authors: Giuliani Matteo , Zaniolo Marta , Castelletti Andrea , Davoli Guido , Block Paul 
Published: October 2019

AbstractIncreasingly variable hydrologic regimes combined with more frequent and intense extreme events are challenging water systems management worldwide. These trends emphasize the need of accurate medium‐ to long‐term predictions to timely prompt anticipatory operations. Despite in some locations global climate oscillations and particularly the El Niño Southern Oscillation (ENSO) may contribute to extending forecast lead times, in other regions there is no consensus on how ENSO can be detected, and used as local conditions are also influenced by other concurrent climate signals. In this work, we introduce the Climate State Intelligence framework to capture the state of multiple global climate signals via artificial intelligence and improve seasonal forecasts. These forecasts are used as additional inputs for informing water system operations and their value is quantified as the corresponding gain in system performance. We apply the framework to the Lake Como basin, a regulated lake in northern Italy mainly operated for flood control and irrigation supply. Numerical results show the existence of notable teleconnection patterns dependent on both ENSO and the North Atlantic Oscillation over the Alpine region, which contribute in generating skilful seasonal precipitation and hydrologic forecasts. The use of this information for conditioning the lake operations produces an average 44% improvement in system performance with respect to a baseline solution not informed by any forecast, with this gain that further increases during extreme drought episodes. Our results also suggest that observed preseason sea surface temperature anomalies appear more valuable than hydrologic‐based seasonal forecasts, producing an average 59% improvement in system performance.
Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
Authors: Snowden John A. , Saccardi Riccardo , Orchard Kim , Ljungman Per , Duarte Rafael F. , Labopin Myriam , McGrath Eoin , Brook Nigel , de Elvira Carmen Ruiz , Gordon Debra , Poirel Hélène A. , Ayuk Francis , Beguin Yves , Bonifazi Francesca , Gratwohl Alois , Milpied Noel , Moore John , Passweg Jakob , Rizzo J. Douglas , Spellman Stephen R. , Sierra Jorge , Solano Carlos , Sanchez-Guijo Fermin , Worel Nina , Gusi Andreu , Adams Gillian , Balan Theodor , Baldomero Helen , Macq Gilles , Marry Evelyne , Mesnil Florence , Oldani Elena , Pearce Rachel , Perry Julia , Raus Nicole , Schanz Urs , Tran Steven , Wilcox Leonie , Basak Grzegorz W. , Chabannon Christian , Corbacioglu Selim , Dolstra Harry , Kuball Jürgen , Mohty Mohamad , Lankester Arjan , Montoto Sylvia , Nagler Arnon , Styczynski Jan , Yakoub-Agha Ibrahim , de Latour Regis Peffault , Kroeger Nicolaus , Brand Ronald , de Wreede Liesbeth C. , van Zwet Erik , Putter Hein 
Published: October 2019

AbstractIn many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) to develop and introduce a universal system accessible across EBMT members. Established systems from seven European countries (United Kingdom, Italy, Belgium, France, Germany, Spain, Switzerland), USA and Australia were appraised, revealing similarities in process, but wide variations in selection criteria and statistical methods. In tandem, the COG developed the first phase of a bespoke risk-adapted international benchmarking model for one-year survival following allogeneic and autologous HSCT based on current capabilities within the EBMT registry core dataset. Data completeness, which has a critical impact on validity of centre comparisons, is also assessed. Ongoing development will include further scientific validation of the model, incorporation of further variables (when appropriate) alongside implementation of systems for clinically meaningful interpretation and governance aiming to maximise acceptance to centres, clinicians, payers and patients across EBMT.
Wetting transitions in droplet drying on soft materials
Authors: Gerber Julia , Lendenmann Tobias , Eghlidi Hadi , Schutzius Thomas M. , Poulikakos Dimos 
Published: October 2019

AbstractDroplet interactions with compliant materials are familiar, but surprisingly complex processes of importance to the manufacturing, chemical, and garment industries. Despite progress—previous research indicates that mesoscopic substrate deformations can enhance droplet drying or slow down spreading dynamics—our understanding of how the intertwined effects of transient wetting phenomena and substrate deformation affect drying remains incomplete. Here we show that above a critical receding contact line speed during drying, a previously not observed wetting transition occurs. We employ 4D confocal reference-free traction force microscopy (cTFM) to quantify the transient displacement and stress fields with the needed resolution, revealing high and asymmetric local substrate deformations leading to contact line pinning, illustrating a rate-dependent wettability on viscoelastic solids. Our study has significance for understanding the liquid removal mechanism on compliant substrates and for the associated surface design considerations. The developed methodology paves the way to study complex dynamic compliant substrate phenomena.
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Authors: Tavernier S. J. , Athanasopoulos V. , Verloo P. , Behrens G. , Staal J. , Bogaert D. J. , Naesens L. , De Bruyne M. , Van Gassen S. , Parthoens E. , Ellyard J. , Cappello J. , Morris L. X. , Van Gorp H. , Van Isterdael G. , Saeys Y. , Lamkanfi M. , Schelstraete P. , Dehoorne J. , Bordon V. , Van Coster R. , Lambrecht B. N. , Menten B. , Beyaert R. , Vinuesa C. G. , Heissmeyer V. , Dullaers M. , Haerynck F. 
Published: October 2019

AbstractHyperinflammatory syndromes are life-threatening disorders caused by overzealous immune cell activation and cytokine release, often resulting from defects in negative feedback mechanisms. In the quintessential hyperinflammatory syndrome familial hemophagocytic lymphohistiocytosis (HLH), inborn errors of cytotoxicity result in effector cell accumulation, immune dysregulation and, if untreated, tissue damage and death. Here, we describe a human case with a homozygous nonsense R688*RC3H1mutation suffering from hyperinflammation, presenting as relapsing HLH.RC3H1encodes Roquin-1, a posttranscriptional repressor of immune-regulatory proteins such as ICOS, OX40 and TNF. Comparing the R688* variant with the murine M199R variant reveals a phenotypic resemblance, both in immune cell activation, hypercytokinemia and disease development. Mechanistically, R688* Roquin-1 fails to localize to P-bodies and interact with the CCR4-NOT deadenylation complex, impeding mRNA decay and dysregulating cytokine production. The results from this unique case suggest that impaired Roquin-1 function provokes hyperinflammation by a failure to quench immune activation.
Transcriptional programming using engineered systems of transcription factors and genetic architectures
Authors: Rondon Ronald E. , Groseclose Thomas M. , Short Andrew E. , Wilson Corey J. 
Published: October 2019

AbstractThe control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to transcriptional effectors. Here we present a biological programming structure that leverages a system of engineered transcription factors and complementary genetic architectures. We use a modular design strategy to create 27 non-natural and non-synonymous transcription factors using the lactose repressor topology as a guide. To direct systems of engineered transcription factors we employ parallel and series genetic (DNA) architectures and confer fundamental and combinatorial logical control over gene expression. Here we achieve AND, OR, NOT, and NOR logical controls in addition to two non-canonical half-AND operations. The basic logical operations and corresponding parallel and series genetic architectures represent the building blocks for subsequent combinatorial programs, which display both digital and analog performance.
Muscle tissue engineering in fibrous gelatin: implications for meat analogs
Authors: MacQueen Luke A. , Alver Charles G. , Chantre Christophe O. , Ahn Seungkuk , Cera Luca , Gonzalez Grant M. , O’Connor Blakely B. , Drennan Daniel J. , Peters Michael M. , Motta Sarah E. , Zimmerman John F. , Parker Kevin Kit 
Published: October 2019

AbstractBioprocessing applications that derive meat products from animal cell cultures require food-safe culture substrates that support volumetric expansion and maturation of adherent muscle cells. Here we demonstrate scalable production of microfibrous gelatin that supports cultured adherent muscle cells derived from cow and rabbit. As gelatin is a natural component of meat, resulting from collagen denaturation during processing and cooking, our extruded gelatin microfibers recapitulated structural and biochemical features of natural muscle tissues. Using immersion rotary jet spinning, a dry-jet wet-spinning process, we produced gelatin fibers at high rates (~ 100 g/h, dry weight) and, depending on process conditions, we tuned fiber diameters between ~ 1.3 ± 0.1 μm (mean ± SEM) and 8.7 ± 1.4 μm (mean ± SEM), which are comparable to natural collagen fibers. To inhibit fiber degradation during cell culture, we crosslinked them either chemically or by co-spinning gelatin with a microbial crosslinking enzyme. To produce meat analogs, we cultured bovine aortic smooth muscle cells and rabbit skeletal muscle myoblasts in gelatin fiber scaffolds, then used immunohistochemical staining to verify that both cell types attached to gelatin fibers and proliferated in scaffold volumes. Short-length gelatin fibers promoted cell aggregation, whereas long fibers promoted aligned muscle tissue formation. Histology, scanning electron microscopy, and mechanical testing demonstrated that cultured muscle lacked the mature contractile architecture observed in natural muscle but recapitulated some of the structural and mechanical features measured in meat products.
Distorted mental spatial representation of multi-level buildings - Humans are biased towards equilateral shapes of height and width
Authors: Ertl M. , Klaus M. , Brandt T. , Dieterich M. , Mast F. W. 
Published: October 2019

AbstractA distorted model of a familiar multi-level building with a systematic overestimation of the height was demonstrated earlier in psychophysical and real world navigational tasks. In the current study we further investigated this phenomenon with a tablet-based application. Participants were asked to adjust height and width of the presented buildings to best match their memory of the dimensional ratio. The estimation errors between adjusted and true height-width ratios were analyzed. Additionally, familiarity with respect to in- and outside of the building as well as demographic data were acquired. A total of 142 subjects aged 21 to 90 years from the cities of Bern and Munich were tested. Major results were: (1) a median overestimation of the height of the multi-level buildings of 11%; (2) estimation errors were significantly less if the particular building was unknown to participants; (3) in contrast, the height of tower-like buildings was underestimated; (4) the height of long, flat shaped buildings was overestimated. (5) Further features, such as the architectonical complexity were critical. Overall, our internal models of large multi-level buildings are distorted due to multiple factors including geometric features and memory effects demonstrating that such individual models are not rigid but plastic with consequences for spatial orientation and navigation.
Versatile format of minichaperone-based protein fusion system
Authors: Yurkova Maria S. , Sharapova Olga A. , Zenin Vladimir A. , Fedorov Alexey N. 
Published: October 2019

AbstractHydrophobic recombinant proteins often tend to aggregate upon expression into inclusion bodies and are difficult to refold. Producing them in soluble forms constitutes a common bottleneck problem. A fusion system for production of insoluble hydrophobic proteins in soluble stable forms with thermophilic minichaperone, GroEL apical domain (GrAD) as a carrier, has recently been developed. To provide the utmost flexibility of the system for interactions between the carrier and various target protein moieties a strategy of making permutated protein variants by gene engineering has been applied: the original N- and C-termini of the minichaperone were linked together by a polypeptide linker and new N- and C-termini were made at desired parts of the protein surface. Two permutated GrAD forms were created and analyzed. Constructs of GrAD and both of its permutated forms fused with the initially insoluble N-terminal fragment of hepatitis C virus’ E2 protein were tested. Expressed fusions formed inclusion bodies. After denaturation, all fusions were completely renatured in stable soluble forms. A variety of permutated GrAD variants can be created. The versatile format of the system provides opportunities for choosing an optimal pair between particular target protein moiety and the best-suited original or specific permutated carrier.