bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience, Occupational Burnout, and Parenting Stress in Nurses Caring for COVID-2019 Patients
Authors: Bashirian Saeid , Bijani Mostafa , Borzou Seyed Reza , Khazaei Salman , mohammadi fateme 
Published: September 2020

Abstract
Background: Caring of COVID-19 patients may have had an impact on the occupational burnout, resilience, and parenting of the nurses. Purpose: Evaluation occupational burnout, resilience, and parenting stress in nurses caring for COVID-19 patients.Methods: The present study is a cross-sectional study. 420 nurses cared for COVID-19 patients in 5 hospitals selected via convenience sampling. Each participant completed the scales online. Data were analyzed in SPSS v. 22.Results: Occupational burnout has a significant negative correlation with resilience and a significant positive correlation with parenting stress and can predict 61.32% of changes in the occupational burnout variance of nurses. Conclusion: Nurses have reported high levels of occupational burnout low levels resilience and high levels tension in their relations with their children. The nurse managers should use these findings to provide appropriate environments for nurses, that to develop more comprehensive plans for support of nurses for the current and future crises.
Disease Associated Protein-Protein Interaction Network Reconstruction Based on Comprehensive Influence Analysis
Authors: Zhu Fei , Li Feifei , Ling Xinghong , Shen Bairong 
Published: September 2020

Abstract
Background: Proteins and their interactions are fundamental to biological systems and they are affecting our body. Functional study of protein networks is becoming increasingly essential to get a deep understanding of proteins and their roles in human life and diseases. Although several methods already exist for protein-protein interaction (PPI) network building, the precise reconstruction of disease associated PPI network remains a challenge. In this paper we introduce a novel concept of comprehensive influence of proteins in network, in which direct and indirect connections are adopted for the calculation of influential effects of a protein with different weights. With the optimized weights, we calculate and select the important proteins and their interactions to reconstruct the PPI network for further validation and confirmation.Results: To evaluate the performance of the method, we compared our model with six existing methods using five standard data sets.Conclusions: The results indicated that our method outperforms the existed ones. We then applied our model to prostate cancer and Parkinson’s disease to predict novel disease associated proteins for the future experimental validation.
Determinants of Emotional Exhaustion Among Nursing Workforce in Urban Ghana: A Cross-sectional Study
Authors: Poku Collins Atta , Donkor Ernestina , Naab Florence 
Published: September 2020

Abstract
Background: The subject of emotional exhaustion in an organisation has become important because of the emerging trends in employment and its related problems. Unhealthy practice environment is a major threat in the incidence of emotional exhaustion among nurses; and organisational cultures that do not support its personnel has huge burnout costs. The study aimed at assessing rate of emotional exhaustion; determined factors that accounts for it and also ascertained the coping strategies used by nurses to overcome it in the Ghanaian health care setting. Methods: A cross-sectional study with a proportionate stratified sampling was used to draw a sample of 232 nurses in five health facilities. A standardized questionnaire of Professional Practice Environment Scale of Nursing Work Index, Maslach Burnout Inventory and Coping Scale were used assess variables under study. The STROBE guidelines were followed in reporting this study.Results: High rate of emotional exhaustion was reported among registered nurses. The practice environment of the nurse explained 39.6% of the variance in emotional exhaustion. Emotion-focused and problem-focused approaches were identified to be used by nurses to cope with emotional exhaustion. Conclusion: When appropriate and effective intervention are employed, emotional exhaustion will be reduce and this will enrich the effectiveness of quality care delivery to patients.
Three-dimensional Analysis of the Root Canal Preparation with Reciproc Blue, WaveOne Gold and XP EndoShaper. A New Method in vivo
Authors: Caviedes-Bucheli Javier , Rios-Osorio Nestor , Usme Diana , Jimenez Cristian , Pinzon Adriana , Rincón Jorge , Azuero-Holguin María M , Zubizarreta-Macho Alvaro , Gomez-Sosa Jose F , Munoz Hugo R 
Published: September 2020

Abstract
Background: Evaluation of changes in volume after root canal preparation. with single file rotary systems such as Reciproc-Blue, WaveOne-Gold and XP-EndoShaper, with a new in vivo study model using CBCT and 3D reconstructions on patients Methods: Thirty human lower premolars were randomly divided into three groups, in which the root canals were prepared using one of these single-file systems: Reciproc-Blue, WaveOne-Gold and XP-EndoShaper. Root canals were scanned before and after root canal preparation using CBCT, and a 3D reconstruction was performed with RHINOCEROS 5.0 software to assess the increase in canal volume for each group after instrumentation. The Anova test was used to determine statistically significant differences between the groups and Post-hoc Tukey's-test to compare the groups with each other. Results: The proposed 3D-reconstruction model allows to measure the variation of the volume within the root canal of the premolars studied. With this model, Reciproc-Blue showed higher increase in canal volume, followed by WaveOne-Gold and XP-EndoShaper (Anova p = 0.003). XP-EndoShaper did not show a statistically significant increase in canal volume after root canal preparation (Tukey's test for paired data p = 0.06 confirmed the results with each other).Conclusion: it is possible to use CBCT and 3D reconstruction as a model to study the preparation quality of the root canal in vivo. With this model, Reciproc-Blue showed higher increase in root canal volume, followed by WaveOne-Gold, while XP-EndoShaper did not significantly increase root canal volume during preparation.
Increased Risk of Ocular Hypertension in Patients with Cushing’s Disease: An Underestimated Comorbidity
Authors: Chen Zhengyuan , Ma Yichen , Ma Zengyi , Ye Zhao , He Wenqiang , Zhang Qilin , He Min , Ye Hongying , Zhang Zhaoyun , Wang Yongfei , Yang Huiyin , Lu Zhaozeng , Wang Zhiliang , Qiao Nidan , Xiao Yiqin , Zhao Yao 
Published: September 2020

Abstract
BackgroundThe association between ocular hypertension and endogenous hypercortisolemia, as well as the ophthalmological outcomes after endocrine remission due to a surgical resection were still unknown. MethodsIntraocular pressure (IOP), visual field and peripapillary retinal nerve fiber layer thickness were documented in all patients with Cushing’s disease (CD) admitted to a tertiary pituitary center for surgery from Jan to Jul 2019. Patients with acromegaly and patients with nonfunctioning pituitary adenoma (NFPA) during the same study period were served as controls. We calculated the odds ratio and identified risk factors of developing ocular hypertension, and presented postoperative trends of IOP.Results52 patients (38.4±12.4 years old) with CD were included. IOP was higher in patients with CD (left 19.4 ± 5.4 mmHg and right 20.0 ± 7.1 mmHg) than patients with acromegaly (left 17.5 ± 2.3 mmHg and right 18.6 ± 7.0 mmHg, p = 0.033) and patients with NFPA (left 17.8 ± 2.6 mmHg and right 17.4 ± 2.4 mmHg, p = 0.005). 21 eyes (20.2%) in patients with CD were diagnosed with ocular hypertension comparing to 4 eyes (4.7%) in the acromegaly group and 4 eyes (4.5%) in the NFPA group. The odds ratio of developing ocular hypertension in patients with CD was 5.1 (95% CI, 1.3 – 25.1, p = 0.029) and 6.6 (95% CI, 1.8 – 30.3, p = 0.007), comparing with the two control groups, respectively. Among patients with CD, those with higher urine free cortisol were more likely to develop ocular hypertension (OR 19.4, 95% CI 1.7 – 72.6). IOP decreased at one-month follow-up in patients with CD and the change sustained at three-month follow-up. ConclusionsIn conclusion, patients with CD had increased risk of developing ocular hypertension comparing to other types of pituitary adenomas, which warrant the discretion of both ophthalmologists and neuroendocrinologists.
Application of Chaotic Encryption Algorithm Based on Variable Parameters in RFID Security
Authors: Liu Baolong , Yang Jianfang , Chen Hua 
Published: September 2020

Abstract
In recent years, chaotic encryption has been well applied in the field of cryptography by virtue of its unique characteristics, and it has received more and more attention in the security of RFID data transmission. Using the same key for encryption and decryption operations is a lightweight encryption algorithm. However, there are various problems in the application process of chaotic encryption: (1) nonlinear dynamic characteristics degradation and short-cycle cycle problems will occur under the influence of computer limited accuracy; (2) numerical conversion operations are required during application, to a certain extent It will affect the randomness of the iterative sequence; (3) During the iterative process, the iterative sequence cannot be spread over the entire value interval, and the randomness is poor. This paper proposes an improved segmented Logistic mapping encryption algorithm, uses the m-sequence to perturb initial value and sets a fixed step to change the control parameter value to generate a chaotic key stream sequence, and applies it to the RFID system data transmission security mechanism to encrypt the data.Experimental simulation and performance analysis show that the iterated chaotic sequence has good random distribution characteristics, unpredictability and traversability. Compared with the previous improvement, the key space is increased to reach the size of 1024 space and can meet the security needs, which improve RFID data security and can effectively avoid various security problems.
Nuclear Reaction Network Unveils Novel Reaction Patterns and Nuclei Stability
Authors: Jiang Chunheng , Szymanski Boleslaw , Havlin Shlomo , Gao Jianxi 
Published: September 2020

Abstract
Despite the advances in discovering new nuclei, modeling microscopic nuclear structure, nuclear reactors, and stellar nucleosynthesis, we lack a systemic tool, in the form of a network framework,
to understand the structure and dynamics of 70 thousands reactions discovered until now.
We assemble here a nuclear reaction network in which a node represents a nuclide, and a link represents a direct reaction between nuclides.
Interestingly, the degree distribution of nuclear network exhibits
a bimodal distribution that significantly deviates from
the power-law distribution of scale-free networks and
Poisson distribution of random networks.
The distribution is universal for reactions with a rate below the threshold,
λ-Tγ, where T is the temperature and γ≈1.05.
We discovered three rules that govern the structure pattern of nuclear reaction network: (i) reaction-type is determined by linking choices, (ii) spatial distances between the reacting nuclides are short,
and (iii) each node in- and out- degrees are close to each other.
By incorporating these three rules, our model
unveils the underlying nuclear reaction patterns hidden
in a large and dense nuclear reaction network.
It enables us
to predict missing links that
represent possible new nuclear reactions not yet discovered.
Travel Habits of Patients with End-Stage Malignant Diseases: A Pilot Study
Authors: Stratmann Jan Alexander , Bitter John , Heringer Olav , Eladly Fadr , Vischedyk Jonas , Ballo Olivier , Hornetz Sofia , Koschade Sebastian , Hossini Nadija , Brandts Christian , Serve Hubert , Wegener Annika , Banek Severine , Shabnam Shaid , Sebastian Martin , Ahrens Marit , Wegener Kerstin 
Published: September 2020

Abstract
Background: Demographic development and continuing improvements in supportive and antineoplastic therapies are reasonable predictors of increasing travel activities carried out by patients with malignant diseases in the near future. There is a lack of data on travel habits of patients with end-stage oncological diseases. Methods: We performed a multi-phased cross-sectional study to gain insights into the intersection of travel medicine and oncology and report the process development and results of a first-in-class comprehensive questionnaire of travel habits in this particular subset of patients. Results: A total of 82 patients with 21 different cancer entities at a median age of 63 years (range, 28-84 years) completed the final questionnaire. 90.2% of all participants rated travelling as an important or very important aspect in their lives, of whom 73.2% had participated in a short- or holiday trip after the cancer diagnosis. All but one (98.8%) participant were about to plan a short- or holiday trip in the near future. Germany (home country) was the most important travel destination, ‘Relaxing’ and ‘enjoying nature’ were the most important travel motives. Fatigue and overall (medical) insecurities were major obstacles to carry out travel plans. Pre-travel advice by a healthcare provider was considered by less than 50% of all participants. Conclusions: In conclusion, a high proportion of patients enjoy national and international travelling. Physicians and patients are encouraged to openly discuss holiday-taking in accordance with available guidelines. More research is needed to fully understand needs and obstacles at the crossroads of travel medicine and oncology.
Neuronal NR4A1 and complement coordinate synaptic stripping by microglia in lupus
Authors: Xiaojuan Han , Tianshu Xu , Qijun Fang , Wang Dandan , Yao Genhong , Hu Gang , Sun lingyun 
Published: September 2020

Abstract
Up to 75% of systematic lupus erythematosus (SLE) patients experience neuropsychiatric (NP) symptoms, called neuropsychiatric SLE (NPSLE), yet the underlying mechanisms remain elusive. Here we showed that complement-coordinated elimination of synapses participated in NPSLE in MRL/lpr mice, a lupus-prone murine model. We demonstrated that lupus mice developed increased anxiety-like behaviors and persistent phagocytic microglia reactivation before overt peripheral lupus pathology. In lupus brain, C1q was increased and localized at synaptic terminals, causing the apposition of phagocytic microglia, ensuing synaptic loss, and neurological disease. We further determined that neuronal Nr4a1 signaling was essential for attracting C1q synaptic deposition and then apposition of phagocytic microglia, resulting in synaptic loss and neurological disease. Minocycline-deactivated microglia, antibody-blocked C1q, or neuronal Nr4a1 restored protected lupus mice from synapse loss and NP manifestations. Our findings revealed an active role of neurons in coordinating microglia-mediated synaptic loss and highlight neuronal Nr4a1 and C1q as critical components amenable to pharmacological intervention in NPSLE.
Trends in Health Behavior and Weight Outcomes Following&nbsp;Enhanced Afterschool Programming Participation: A Pragmatic Quasi-experimental Study
Authors: Rieder Jessica , Moon Jee-Young , Joels Joanna , Shankar Viswanathan , Meissner Paul , Johnson-Knox Elicia , Frohlich Bailey , Davies Shelby , Wylie-Rosett Judy 
Published: September 2020

Abstract
Background: The United States needs to increase access to effective obesity prevention and treatment programming for impoverished youth at risk for health disparities. Although interventions targeting schools are recommended, schools rarely implement evidence-based obesity programing.Methods: Using a pragmatic quasi-experimental design, we report on the effectiveness of adding structured nutrition education and minimum physical activity (PA) requirements to standard middle school onsite afterschool programming. Programming was evaluated over three school years (2016- 2018) to determine: 1) impact on healthy weight and target healthy behavior attainment; and 2) whether target behavior improvement was associated with afterschool program attendance and weight change.Results: In response to 601 recruitment letters 13% (76 students) enrolled (62% Hispanic, 46% girls, 72% with BMI > 85 th %ile, 49% with BMI > 95 th %ile). With low baseline attainment of 7 target behaviors including:1) daily breakfast and lunch (32%); 2) 2-3 servings fruit/day (53%); 3) > 3 servings vegetables/day (29%); 4) 8 cups sugar-free beverages (SFB)/day and <1 cup sugary beverage/day (9%); 5) > 8 hours sleep/night (75%); 6) > 7 hours PA/week (21%); and 7) < 1 unhealthy snack (US) and <1 fast food meal/week (25%), the calculated composite score was 2.5 out of 7. Of students with BMI > 85 th %ile, 44% maintained or decreased BMI Z-score. There were non-significant trends in improvements in BMI Z-score and target consumption of: fruit, vegetables, SFB, and US food. Students with higher afterschool attendance ( > 75%) had greater non-significant improvements in composite score, BMI Z-score, and in most target behaviors (5/7) compared to students with lower afterschool attendance (<75%). Although not significant, improvements in composite score attainment and most target behaviors (5/7) were associated with decreases in BMI Z-score. Sleep improvements were significantly associated with BMI Z-score decrease (Beta=-0.05, 95% CI (-0.1,-0.003), p=0.038.) Conclusions : Enhancement of existing afterschool programming with health oriented elements and minimum physical activity requirements demonstrates trends toward improvement in several health behaviors and weight outcomes. Addition of enhanced programming increases access to health activities and may bring us closer to solving issue of obesity in at-risk youth in impoverished communities.Trial registration: ClinicalTrials.gov identifier (NCT number): NCT03565744. Registered 21 June 2018 – Retrospectively registerd, https://register.clinicaltrials.gov/prs/app/action/LoginUser?ts=1&cx=-jg9qo4.
Coordination of microbe-host homeostasis via a crosstalk with plant innate immunity
Authors: Ma Ka-Wai , Niu Yulong , Jia Yong , Ordon Jana , Copeland Charles , Emonet Aurélia , Geldner Niko , Guan Rui , Stolze Sara , Nakagami Hirofumi , Garrido-Oter Ruben , Schulze-Lefert Paul 
Published: September 2020

Abstract
Asymptomatic plants grown in natural soil are colonized by phylogenetically structured communities of microbes known as the microbiota. Individual microbes can activate microbe-associated molecular pattern (MAMP)-triggered immunity (MTI), which limits pathogen proliferation but curtails plant growth, a phenomenon known as the growth-defense trade-off. We report that in mono-associations, 41% (62/151) of taxonomically diverse root bacterial commensals suppress Arabidopsis thaliana root growth inhibition (RGI) triggered by immune-stimulating MAMPs or damage-associated molecular patterns. Amplicon sequencing of bacteria 16S rRNA genes reveal that immune activation alters the profile of synthetic communities (SynComs) comprised of RGI-non-suppressive strains, while the presence of RGI-suppressive strains attenuates this effect. Root colonization by SynComs with different complexities and RGI-suppressive activities alters the expression of 174 core host genes with functions related to root development and nutrient transport. Further, RGI-suppressive SynComs specifically downregulate a subset of immune-related genes. Pre-colonization with RGI-suppressive SynComs, or mutation of one commensal-downregulated transcription factor, MYB15, render plants more susceptible to opportunistic Pseudomonas pathogens. Our results suggest that RGI-non-suppressive and suppressive root commensals modulate host susceptibility to pathogens by either eliciting or dampening MTI responses, respectively. This interplay buffers the plant immune system against pathogen perturbation and defense-associated growth inhibition, ultimately leading to commensal-host homeostasis.
Clinical efficacy and predictive biomarkers of ONC201 in H3 K27M-mutant diffuse midline glioma
Authors: Koschmann Carl , Kawakibi Abed Rahman , Tarapore Rohinton , Gardner Sharon , Thomas Chase , Cartaxo Rodrigo , Yadav Viveka , Chi Andrew , Kurz Sylvia , Wen Patrick , Arrillaga Isabel , Batchelor Tracy , Butowski Nicholas , Sumrall Ashley , Shonka Nicole , Harrison Rebecca , Groot John De , Mehta Minesh , Odia Yazmin , Hall Matthew , Daghistani Doured , Cloughesy Timothy , Ellingson Benjamin , Kim Michelle , Umemura Yoshie , Garton Hugh , Franson Andrea , Robertson Patricia , Schwartz Jonathan , Marini Bernard , Pai Manjunath , Phoenix Timothy , Ji Sunjong , Cantor Evan , Miklja Zachary , Mullan Brendan , Bruzek Amy , Siada Ruby , Cummings Jessica , Stallard Stefanie , Wierzbicki Kyle , Paul Alyssa , Wolfe Ian , Dun Matthew , Cain Jason , Jiang Li , Filbin Mariella , Vats Pankaj , Kumar-Sinha Chandan , Mody Rajen , Chinnaiyan Arul , Pratt Drew , Venneti Sriram , Lu Guangrong , Mueller Sabine , Resnick Adam , Nazarian Javad , Waszak Sebastian , Allen Joshua 
Published: September 2020

Abstract
Patients with diffuse midline glioma (DMG) harboring H3 K27M mutation have no proven therapies beyond radiation. ONC201, a DRD2 antagonist and mitochondrial ClpP agonist, has induced early responses in patients with H3 K27M-mutant DMG. We performed an integrated pre-clinical and clinical assessment of ONC201 treatment, in order to define response rates in H3 K27M-mutant DMG patients and to clarify predictors of response. ONC201 was effective in murine H3 K27M-mutant gliomas with excellent CNS penetration and survival benefit. H3 K27M-mutant DMG patients treated with ONC201 on active clinical trials (n=50) showed significant survival benefit in recurrent and non-recurrent settings, with multiple sustained responses. Tumor sequencing from treated patients demonstrates an EGFR/FOXG1-driven telencephalic gene regulatory network that imparts a critical resistance phenotype to ONC201. Genetic and pharmacologic knockdown of EGFR in H3 K27M-mutant cell cultures results in improved sensitivity to ONC201 and reduced FOXG1 enhancer binding, suggesting possible future combinatorial opportunities.
Photoreceptor degeneration and choroidal neovascularization in aged BALB/c mice following systemic neonatal murine cytomegalovirus infection
Authors: Xu Jinxian , Liu Xinglou , Zhang Xinyan , Marshall Brendan , Dong Zheng , Smith Sylvia , Espinosa-Heidmann Diego , Zhang Ming 
Published: September 2020

Abstract
Age-related macular degeneration (AMD) represents a leading cause of irreversible visual dysfunction in older individuals but its genesis is poorly understood. Human cytomegalovirus (HCMV), which infects 50 to 80% of humans, is usually acquired during early life and persists in a latent state for the life of the individual. Here we show that systemic neonatal murine cytomegalovirus (MCMV) infection of BALB/c mice resulted in dissemination of virus to the eye where it localized to choroidal endothelial cells and RPE cells. MCMV underwent ocular latency in all neonatally infected mice and latent/persistent ocular infection was associated with expression of MCMV immediate early genes, significant upregulation of several inflammatory/angiogenic factors. AMD–like pathology, including basal lamina deposits (BLamD), subretinal drusenoid deposits (SDD), severe photoreceptor degeneration, choroidal neovascularization (CNV) develop in eyes of latently-infected aged mice. Our study suggests a possible viral etiology for AMD as a result of latent/persistent ocular CMV infection.