bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Novel Immunological Biomarkers as Potential Determinants of Chronic Inflammation in Virologically Suppressed HIV-1 Positive Patients Receiving Antiretroviral Therapy
Authors: Maritati Martina , Alessandro Trentini , Zanotta Nunzia , Comar Manola , Bellini Tiziana , Sighinolfi Laura , Contini Carlo 
Published: June 2020

Abstract
Background:Although HIV-related deaths have decreased dramatically following the introduction of antiretroviral therapy (ART), HIV infection itself causes increased morbidity and mortality for both non-AIDS-related events or chronic inflammation and immune activation. The use of certain antiretroviral drugs can contribute to this process. Methods:We investigated 26 potential biomarkers in serum samples from HIV-1 infected patients virologically suppressed under ART. The mailobjective of our study was to evaluate if virological suppression achieved with a triple drug regimen containing tenofovir disoproxil fumarate co-formulated with emtricitabine (TDF/FTC) as backbone, could correlate with a better immunological and inflammatory profile in relation to the third class of antiretroviral drug administered. The eligible patients were then divided into 3 groups in relation to the third drug associated with TDF/FTC : NNRTI (Group 1, n=18), + PI (Group 2, n=18) and INI (Group 3, n=18). Results: Traditionally, inflammatory cytokines and chemokines were more represented in Group 2 than in Group 3 (IL-1Ra, p=0.013; IL-12p70 p=0.039; TNF-α p=0.041; IL-8, p=0.027; MIP1 β, p=0.033). Eotaxin showed lower levels in Group 1 compared to Group 2 (p=0.010), while IP-10 was significantly lower in Group 1 compared to both Group 2 and Group 3 (p=0.003 and p=0.007, respectively).Conclusions: our results seem to discourage the administration of PI as a third drug in a virologically effective antiretroviral regimen, as its use is linked to the detection of higher levels of pro-inflammatory mediators than INI and NNRTI.
Determination of 5-Hydroxymethylfurfural, NƐ-(Carboxymethyl)Lysine and NƐ-(Carboxyethyl)Lysine in 16 Traditional Chinese Medicine Injections Based on HPLC and UPLC-MS/MS
Authors: Zhang Lei , Gong Ruize , Liu Chang , Sun Yinshi 
Published: June 2020

Abstract
Background: Traditional Chinese medicine injections (TCMIs) are widely applied to treat many chronic diseases. However, product quality problems occur occasionally due to unknown constituents in TCMIs. 5-hydroxymethylfurfural (5-HMF), NƐ-(carboxymethyl)lysine (CML) and NƐ-(carboxyethyl)lysine (CEL) are three compounds generated during food and Chinese medicinal herb processing and may be harmful to human health. Methods: In this study, the contents of 5-HMF, CML and CEL were determined by high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC). For 5-HMF, the separation was performed on a Hypersil ODS2 column (250 mm×4.6 mm, 5 µm), and the column temperature was set at 30℃. The mobile phase was composed of water-methanol (95:5) at a flow rate of 1.0 mL/min. For CML and CEL, separation was performed on a CORTECS HILIC UPLC column (2.1 mm×50 mm, 1.6 µm), and the column temperature was set at 40℃. The mobile phase was composed of acetonitrile-water (3:7) at a flow rate of 0.3 mL/min. Multiple-reaction monitoring mode was employed for analyte determination with positive ionization. Results: The contents of 5-HMF in 16 TCMIs varied from 0.19 to 74.98 µg/mL, with a larger variation than the contents of CML and CEL. The Ciwujia injection had the highest content of 5-HMF, and the Qingkailing injection had the lowest 5-HMF content. The contents of CML and CEL among these TCMIs were 0.51-7.32 ng·mL-1 and 0.38-5.49 ng·mL-1, respectively. The contents of CML and CEL in the Shuxuetong injection were much higher than in the others.Conclusions: The methods established in this study were simple, rapid and accurate and could provide a theoretical basis for the quality evaluation of TCMIs.
Removal of phenolic compounds from aqueous solution using MgCl2-impregnated activated carbons derived from olive husk: the effect of chemical structures
Authors: Hamadneh Imad , Abu-Zurayk Rund A. , Al-Dujaili Ammar H. 
Published: June 2020

AbstractActivated carbon (BC) prepared from olive oil solid waste (olive husk) by slow pyrolysis was chemically activated using MgCl2 (BC-MgCl2). The BC and BC-MgCl2 were used as adsorbents for removal of three phenolic compounds, namely, phenol (P), p-methoxyphenol (PMP) and p-nitrophenol (PNP), from aqueous solution. The uptake of these three phenolic compounds by the BC and BC-MgCl2 was better expressed by the Langmuir and Dubinin–Radushkevich (D-R) isotherm models than by the Freundlich isotherm, and the kinetics of the adsorption process followed the pseudo-second order kinetic model. The maximum monolayer adsorption capacity of P, PMP and PNP were increased from 24.938, 45.455 and 61.728 on BC to 43.860, 98.039 and 121.951 mg/g on BC-MgCl2 by factors of 1.76, 2.16 and 1.98, respectively. Therefore, the chemical activation of BC by MgCl2 is indeed of importance for improving its adsorption performances. For both adsorbents, the adsorption phenomenon for different substituted phenols is a strong function of solubility, polarity, molecule structure, and size. At the tested temperatures (25, 35 and 45 °C), the negative values of ΔG° and positive values of ΔH° and ΔS° for the adsorption of P, PMP and PNP on BC and BC-MgCl2 demonstrated that the adsorption was a spontaneous, endothermic and entropy-increasing process.
An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors
Authors: Gu Haijun , Peng Yangrui , Chen Yihua 
Published: June 2020

:Myoferlin (MYOF), as a member of the ferlin family, is a type II transmembrane protein with a single transmembrane domain at the carbon terminus. Studies have shown that MYOF is involved in pivotal physiological functions related to numerous cell membranes, such as extracellular secretion, endocytosis cycle, vesicle trafficking, membrane repair, membrane receptor recycling, and secreted protein efflux. Recently, the studies have also revealed that MYOF is overexpressed in a variety of cancers such as colorectal cancer, pancreatic cancer, breast cancer, melanoma, gastric cancer, and non-small-cell lung cancer. High expression of MYOF is associated with the high invasion of tumors and poor clinical prognosis. MYOF medicates the expression, secretion, and distribution of proteins, which were closely related to cancers, as well as the energy utilization of cancer cells, lipid metabolism and other physiological activities by regulating the physiological processes of membrane transport. In this short article, we briefly summarize the latest progress related to MYOF, indicating that small molecule inhibitors targeting the MYOF-C2D domain can selectively inhibit the proliferation and migration of cancer cells, and MYOF may be a promising target for the treatment of malignant tumors.
Optimization of the Engine Operation Mode at Vector Control
Authors: Morozov A. V. , Barsukov V. K. 
Published: June 2020

Для регулирования вращающего момента асинхронного двигателя применяется векторное управление, позволяющее формировать необходимые значения пространственных векторов тока и напряжения статора в любой момент времени. В статье приведены результаты исследования параметров тягового асинхронного привода технологической электротележки при использовании различных критериев оптимизации значений величин. Исследован критерий минимума тока статора, который выполняется при равенстве проекций вектора тока на оси синхронной системы отсчета. Также исследован критерий минимизации потерь мощности в двигателе и предложен способ его обеспечения на основе известных данных опытов холостого хода и короткого замыкания и параметров схемы замещения двигателя. Все составляющие мощности потерь – потери в обмотках статора и ротора, магнитопроводе статора – выражаются в виде функций продольного тока статора, после чего находится экстремум их суммы. Результаты расчета затрат энергии и потерь мощности в двигателе при выполнении одного рабочего цикла позволяют говорить о том, что предложенный способ расчета и задания продольного и поперечного токов обеспечивает КПД двигателя в среднем на 3 процента больший, чем при поддержании минимума тока статора.
Biological Potential of Caesalpinia bonducella Seeds: A Review
Authors: Gadakh M.J. , Jadhav R.S. , Vikhe D.N. 
Published: June 2020

Caesalpinia bonducella L. is a medicinal plant belonging to the family Caesalpiniaceae. The plant is found in all over India. The plant is a large prickly shrub. It is popular in indigenous system of medicine like Ayurveda, Siddha, Homoeopathy and Unani. In Indian traditional plant medicine, it has been considered as an important remedy for the treatment of several diseases. The plant has been reported to possess antimalarial, antifungal, antioxidant, anticancer, antipyretic, antifertility antiviral and antimalarial etc. activities of various parts of C bonducella plant. It can be concluded that C. bonducella can become the best source of medicine in future on various ailments with further investigations. Hence attempts have been made to take collect and compile the information about the traditional use of various parts of C.bonducella in various ailments, chemical constituents from various parts and the effective use of various extracts for treatment of different diseases.
Keywords: Caesalpinia bonducella , Pharmacology, Nutritional Values.
Immunomodulators for Curtailing COVID-19: a Positive Approach
Authors: Bhat Shabir Ahmad , Rather Shameem Ahmad , Iqbal Arsheed , Qureshi Haider Ali , Islam Naquibul 
Published: June 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly infectious, spreading swiftly from man to man which has not been previously recognized in humans. World Health Organization (WHO) on February 11, 2020 named the infection as COVID-19 as an acronym for ‘coronavirus disease-2019’ and on March 11, 2020 declared the outbreak as pandemic. It affects all the people without discrimination, however, older, immune compromised are more susceptible. The virus chiefly spread through droplet infection from infected person to healthy one by coughing, sneezing or with infected hands when touched to eyes, nose or mouth. Symptoms of the infection range from mild to severe ones. In severe cases (approx. 14% of cases) fever typically of high grade (104oF), breathlessness, pneumonia and severe acute respiratory syndrome may appear. So far no specific treatment or vaccine for novel coronavirus-2019 is there. From the past and recent past experiences we have learnt that herbal medicines have proven beneficial against various dreadful viral infections. Assessment of immune enhancing herbs in this paper may definitely be helpful for the body to fight COVID-19 infection.
Keywords: Severe acute respiratory syndrome coronavirus-2, COVID-19, Pneumonia, Immune, Herbs
Cell Biology in Rheumatoid Arthritis
Authors: Sahu Lukeshwari , Rao S. Prakash , Verma Mahendra , Kumar Akhilesh , Sahu Rajendra , Kumar Dhanesh , Yadav Chandrakant 
Published: June 2020

Rheumatoid arthritis (RA) is a systemic autoimmune disease, which affects about 0.33 to 2.65% of the population. In RA Synovium contain various type of immune cell. In which only one cell population cannot cause rheumatoid arthritis that requires more than one cell population. In normal condition, they act as a switch (active or inactive the cell signaling). It controls cell growth, proliferation or metastasizes. In an autoimmune disorder such as rheumatoid arthritis, the immune system mistakenly attacks and destroys the body's cells and tissues. Mostly cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases, this population can expand to constitute 5-20% or more of all synovial cells. Recent investigations in a murine model have demonstrated that cells can have a critical role in the generation of inflammation within the joint.
Keyword: Cell Biology in rheumatic arthritis; Dendrite cell; T-cell; Mast cell; Fibroblastic cell; Macrophages cell.
A Novel Coronavirus (nCOV- 2019): A Pandemic Severe Respiratory Tract Infections by SARS COV-2 in Human
Authors: Jadhao Vikram , Bodhe Roshan , Mahajan Hitendra , Jadhav Vikram , Patil Kishor , Baheti Nupur , Kale Neha 
Published: June 2020

Novel Coronavirus Disease 2019 (nCOV 2019) or Coronavirus is one which is associate communicable disease amongst variety of viruses that causes cold, fever, difficulty in breathing and ultimately death. The viruses cause metabolism infections, together with the mundane cold, that square measure usually delicate, although a lot of occasional forms like respiratory illness caused by SARS-CoV-2, the illness is that the reason for the 2019–20 coronavirus irruption. It’s primarily unfolded between individuals by diminutive droplets from infected people once they breathe or cough. Individuals could have few symptoms or develop febrility, cough, and shortness of breath. Whereas Feb 2020, different countries together with European country Asian Countries enclosed within the list. Antiviral drugs being tested embrace antimalarial drug, the ribonucleic acid enzyme substance remdesivir, and triazavirin, Umifenovir (Arbidol) and darunavir were planned. Remdesivir and antimalarial drug effectively inhibit the coronavirus in vitro. Favilavir approved as experimental corona virus drug. The objective of this review article to provide basic knowledge & preliminary opinion and to provide an advice which can be proved as the best mantra for defeating nCOV. Thus this review aims to throw light to the new and exciting areas of Virology, Replication cycle of corona virus , sign & symptoms and diagnosis, Spreading of corona virus, Structural biology of corona virus, the ways of treatment with alternative medicines other than antiviral drugs, and prevention in its early stage of COVID-19 , and also Current Research on Corona.
Keywords: Coronavirus, 2019-nCOV2, 2019–20 coronavirus irruption, SARS, WHO, Public Health Emergency of International Concern (PHEIC), replication of corona virus.
Computational Quantum Chemical Study, Drug-Likeness and In Silico Cytotoxicity Evaluation of Some Steroidal Anti-Inflammatory Drugs
Authors: Bououden Walid , Benguerba Yacine 
Published: June 2020

This paper contains a theoretical study of ten Anti-inflammatory steroids (AIS) on the understanding of the relationship between the structure and activity of the drug, the pharmacokinetic parameters responsible for bioavailability and bioactivity and finally the toxicity evaluation. DFT calculations with B3LYP/6-31G (d, p) level have been used to analyze the electronic and geometric characteristics deduced for the stable structure of the compounds. Moreover, using the Frontier Molecular orbital (FMO) energies, MEP surface visualizations and the density-based descriptors such as chemical potential (µ), electronegativity (χ), hardness (η) and softness (σ), the chemical stability were determined. Furthermore, in silico, studies showed that Lipinski rules are applied, which means that these (AIS) are expected to have a high probability of good oral bioavailability. On the other side, the bioinformatic Osiris/Molinspiration analyses of the relative cytotoxicity of these derivatives are reported in comparison to Cortisol. In fact, it has been showed that almost of these compounds are non-toxics except for Mometasone that presents a great risk of tumorigenicity during reproduction with a slightly mutagenic structure due to the two chloride atoms. from all results obtained, we can conclude that fluticasone has the best physico-chemical properties which explains its high efficiency.
Keywords: Anti-inflammatory steroids, DFT, Lipinski rules, Tumorigenicity.
Morphology, Phytochemistry and Pharmacological Activity of Vitex negundo: An Overview
Authors: Singh Yogendra , Mishra Pankaj , Kannojia Pushpendra 
Published: June 2020

Now days a herbal and traditional medicines mostly used in all over the world according to WHO, about 60 to 65% world population practicing herbal and traditional medicines. Vitex negundo Linn. is an aromatic herb belong to family Verbenaceae. It is also known as Nirgundi, Five leaved chaste tree. Plants have many chemical constituents as flavonoids, volatile oil, triterpenes, diterpenes, sesquiterpenes, lignan, flavones, glycosides, iridoid glycosides and stilbene derivative. These chemical constituents are present in each part of the plant. Vitex negundo extract have various pharmacological activities such as anti-inflammatory, antipyretic, anti-arthritic, antioxidant, analgesic activity, antibacterial activity, antitumor activity, anti-amnesic activity, anxiolytic activity, Nephroprotective activity, anti-HIV activity, Antitubercular activity, antieosinophilic activity, anti-snake venom activity. This review article provides depth information related to plant morphology, cultivation, chemical constitutes, pharmacological activities and their medicinal uses.
Keywords: Vitex negundo, Nirgundi, Casticin, Anti-Gout Activity
Monipuolinen esitys (lähes) tuntemattomasta maanlainsuomennoksesta
Authors: De Smit Merlijn 
Published: June 2020

Arvioitu teos:
Harri Uusitalo: Tausta, tekijä ja kieli. Filologinen tutkimus Aitolahden koodeksin lainsuomennoksesta. Turun yliopiston julkaisuja C471. Turku 2019. 159 s. ja liitteet 186 s. isbn 978-951-29-7668-3. Saatavilla verkossa osoitteessa http://urn.fi/URN:ISBN:978-951-29-7669-0
PEP – USING SMARTPHONE AND RUBRICS TO EVALUATE LARGE GROUPS IN PROJECT-BASED COURSE
Authors: Collin Jérôme , Thériault Lévis 
Published: June 2020

This paper presents a new computer tool used to evaluate a large number of student teams using rubrics. The system makes use of smartphones and tablets to enter marks on a web site where all results are stored and processed. Various data can be exported at the end. The new system uses scrollers to quickly fill out the rubric on a smartphone. This system has reduced the amount of paper, the number of errors and the time to manually process all the marks of a first-year project-based course at Polytechnique Montréal. An administrator with a laptop can create, manage and follow the evaluation event itself more easily compared to the paper version.
STUDENT AND FACULTY PERCEPTIONS OF CAPSTONE PURPOSES: WHAT CAN ENGINEERING LEARN FROM OTHER DISCIPLINES?
Authors: Vale Julie , Gordon Karen , Kirkscey Russell , Hill Jennifer 
Published: June 2020

Capstone Experiences (CE) are meant to integrate and culminate the student experience. The most common CE in the Canadian and American engineering curriculums is the final year design course, but other disciplines also have capstone experiences. This paper presents initial results from a multi-institutional, multi-national survey of faculty and student perceptions of capstone experiences. Here, we investigate three criteria (Values, Skills/competencies, Attitudes) and discuss differences and similarities among the disciplines and between engineering students and faculty. There is good alignment between engineering faculty and students, but values such as openness and compassion are selected at (comparatively) lower rates by engineering faculty and students than by other disciplines. These findings provide an opportunity for engineering educators to reflect on the intentions of their CE; e.g., are these results an intentional outcome of engineering capstones, or an oversight on the part of engineering educators?
CONSIDERATIONS FOR DEVELOPMENT OF CRITICAL REFLECTION SKILLS IN FIRST-YEAR ENGINEERING INFORMED THROUGH STUDENT PERSPECTIVES
Authors: DaMaren Elizabeth , Pearlston Danielle , Mattucci Stephen 
Published: June 2020

Reimagined curriculum models offer new possibilities for embedding durable competencies into the curriculum, including critical reflection, which promotes the development of self-directed learning skills. However, students often perceive these skills as unimportant with pre-existing biases focusing on technical content as the core of engineering. The primary goal of this work was to identify key considerations when integrating critical reflection into engineering curricula, specifically in the context of first-year engineering, to promote the development of student self-directed learning skills. This work was framed within the Students-as-Partners (SaP) approach, where two undergraduate students worked in collaboration with the instructor. To gather information regarding student perceptions of critical reflection, focus groups were conducted for first-year engineering students and students familiar with reflection. Qualitative thematic analysis was performed on the focus group data and key insights were identified and categorized into five themes: approaches, supporting students, evaluation and framing, development pathway and value, and reflection for engineers. Suggested learning outcomes, student activities, and evaluation methods are proposed. These findings are applicable to implementing reflection across a variety of academic settings, as they highlight main considerations and challenges faced with reflection from the perspective of students in multiple programs.
Atuação de enfermagem frente ao atendimento ao paciente hipertenso: uma revisão integrativa
Authors: Sampaio Samyra Maria Lima , Sousa Allex Alves Sobral de , Queiroz Iasmin Belém Silva , Luna Cícera Alves de , Gurgel Lucineide Coqueiro , Luna Thayná Bezerra de , Sousa Carmelita Maria Silva , Sousa Francisco Rafael Soares de , Luz Dayse Christina Rodrigues Pereira , Santana Willma José de 
Published: June 2020

Objetivo: Realizar uma revisão na literatura para verificar a atuação da enfermagem frente ao atendimento ao paciente hipertenso. Métodos: Trata-se de um estudo realizado por meio do método de revisão integrativa da literatura com abordagem qualitativa. Os estudos foram selecionados por meio de busca eletrônica nas bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS/BIREME) e Scientific Eletronic Library Online (SciELO), Science Direct e Banco de dados em Enfermagem. Foram utilizados na busca dos estudos os Descritores em Ciências da Saúde (Decs): Enfermagem, Hipertensão e Promoção da saúde. Resultados: A ingestão, de forma descontrolada e muitas vezes excessiva de sódio na dieta tem demonstrado uma correlação com a elevação da PA. A adesão ao tratamento tanto da hipertensão arterial, como para as demais doenças crônicas tem sido foco de vários estudos, e tem gerado várias discussões por profissionais de saúde. Considerações finais: Portanto, a importância do conhecimento de forma integral dos mais diversos saberes ao trabalho em equipe, favorece o tratamento da hipertensão arterial.