bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology, prenatal diagnosis, and neonatal outcomes of congenital heart defects in eastern China: a hospital-based multicenter study
Authors: Zhang Xiaohui , Sun Yu , Zhu Jiajun , Zhu Yuning , Qiu Liqian 
Published: September 2020

Abstract
Background
Congenital heart defect is the leading malformation in China. There may have been changes in congenital heart defect incidence because of birth policy shift in China over past years. This study aimed to investigate the epidemiology, prenatal diagnosis, and outcomes of congenital heart disease to improve medical and policy decisions.

Methods
Data on cases of congenital heart disease identified during 2014–2018 were taken from the Zhejiang provincial birth defects surveillance system. Chi-square test, odds ratio (OR) and 95% confidence interval (CI) were used to explore epidemiology, prenatal diagnosis, and birth outcomes of congenital heart disease.

Results
The average incidence of congenital heart disease was 16.0 per 1000 births, which increased by 62.2% during 2014–2018(χ2trend = 181.41, P < 0.001). However, the average critical congenital heart incidence was 1.6 per 1000 births, which remained stable over time. Women aged ≤20 years (OR2.1, 95% CI 1.9–2.3) or ≥ 35 years (OR 1.2, 95% CI 1.2–1.3) were at higher risk of having babies with congenital heart disease than women aged 21–34 years. Women who gave birth in urban areas (OR 1.2, 95% CI 1.2–1.3), had a son (OR 1.3, 95% CI 1.3–1.4), or had multiple births (OR 4.0, 95% CI 3.7–4.4) were also at higher risk than those giving birth in rural areas, to girls, or single births, respectively. The three major subtypes of congenital heart disease were atrial septal defect (67.9%), patent ductus arteriosus (34.7%), and ventricular septal defect (6.4%). The prenatal detection rate of critical congenital heart disease was 90.0%, which was far higher than total congenital heart disease, at 22.2% (χ2 = 1687.67, P < 0.001). There were 1457 (17.1%) stillbirths, 106 (1.2%) early neonatal deaths, and 6983 (81.7%) live births associated with congenital heart disease.

Conclusions
The high incidence of congenital heart disease in Zhejiang might be attributable to the large proportion of mild congenital heart disease. The incidence of critical congenital heart disease, the prenatal detection rate, and perinatal deaths from congenital heart disease are comparable to those in other studies.
Towards more efficient use of intravenous lumens in multi-infusion settings: development and evaluation of a multiplex infusion scheduling algorithm
Authors: Doesburg Frank , Oelen Roy , Renes Maurits H. , Bult Wouter , Touw Daan J. , Nijsten Maarten W. 
Published: September 2020

Abstract
Background
Multi-drug intravenous (IV) therapy is one of the most common medical procedures used in intensive care units (ICUs), operating rooms, oncology wards and many other hospital departments worldwide. As drugs or their solvents are frequently chemically incompatible, many solutions must be administered through separate lumens. When the number of available lumens is too low to facilitate the safe administration of these solutions, additional (peripheral) IV catheters are often required, causing physical discomfort and increasing the risk for catheter related complications. Our objective was to develop and evaluate an algorithm designed to reduce the number of intravenous lumens required in multi-infusion settings by multiplexing the administration of various parenteral drugs and solutions.

Methods
A multiplex algorithm was developed that schedules the alternating IV administration of multiple incompatible IV solutions through a single lumen, taking compatibility-related, pharmacokinetic and pharmacodynamic constraints of the relevant drugs into account. The conventional scheduling procedure executed by ICU nurses was used for comparison. The number of lumens required by the conventional procedure (LCONV) and multiplex algorithm (LMX) were compared.

Results
We used data from 175,993 ICU drug combinations, with 2251 unique combinations received by 2715 consecutive ICU patients. The mean ± SD number of simultaneous IV solutions was 2.8 ± 1.6. In 27% of all drug combinations, and 61% of the unique combinations the multiplex algorithm required fewer lumens (p < 0.001). With increasing LCONV, the reduction in number of lumens by the multiplex algorithm further increased (p < 0.001). In only 1% of cases multiplexing required > 3 lm, versus 12% using the conventional procedure.

Conclusion
The multiplex algorithm addresses a major issue that occurs in ICUs, operating rooms, oncology wards, and many other hospital departments where several incompatible drugs are infused through a restricted number of lumens. The multiplex algorithm allows for more efficient use of IV lumens compared to the conventional multi-infusion strategy.
Children as sentinels of tuberculosis transmission: disease mapping of programmatic data
Authors: Gunasekera Kenneth S. , Zelner Jon , Becerra Mercedes C. , Contreras Carmen , Franke Molly F. , Lecca Leonid , Murray Megan B. , Warren Joshua L. , Cohen Ted 
Published: September 2020

AbstractBackgroundIdentifying hotspots of tuberculosis transmission can inform spatially targeted active case-finding interventions. While national tuberculosis programs maintain notification registers which represent a potential source of data to investigate transmission patterns, high local tuberculosis incidence may not provide a reliable signal for transmission because the population distribution of covariates affecting susceptibility and disease progression may confound the relationship between tuberculosis incidence and transmission. Child cases of tuberculosis and other endemic infectious disease have been observed to provide a signal of their transmission intensity. We assessed whether local overrepresentation of child cases in tuberculosis notification data corresponds to areas where recent transmission events are concentrated.MethodsWe visualized spatial clustering of children < 5 years old notified to Peru’s National Tuberculosis Program from two districts of Lima, Peru, from 2005 to 2007 using a log-Gaussian Cox process to model the intensity of the point-referenced child cases. To identify where clustering of child cases was more extreme than expected by chance alone, we mapped all cases from the notification data onto a grid and used a hierarchical Bayesian spatial model to identify grid cells where the proportion of cases among children < 5 years old is greater than expected. Modeling the proportion of child cases allowed us to use the spatial distribution of adult cases to control for unobserved factors that may explain the spatial variability in the distribution of child cases. We compare where young children are overrepresented in case notification data to areas identified as transmission hotspots using molecular epidemiological methods during a prospective study of tuberculosis transmission conducted from 2009 to 2012 in the same setting.ResultsAreas in which childhood tuberculosis cases are overrepresented align with areas of spatial concentration of transmission revealed by molecular epidemiologic methods.ConclusionsAge-disaggregated notification data can be used to identify hotspots of tuberculosis transmission and suggest local force of infection, providing an easily accessible source of data to target active case-finding intervention.
Intraosseous epidermoid cysts of adjacent digits in a dog
Authors: Vagias Michail , Cassidy Joseph P. , Skelly Cliona , Mullins Ronan A. 
Published: September 2020

AbstractBackgroundIntraosseous epidermoid cyst (IEC) is a rare, non-neoplastic, pathology in animals and humans that most commonly affects the distal phalanx. In dogs, it is important to differentiate this lesion from malignant digital tumours causing bone lysis. In previous reports, IEC has been described to affect only a single digit at the time of diagnosis which is usually based on histopathology. This is the first case report to describe immunohistochemically confirmed IECs affecting simultaneously multiple digits.Case presentationA 4-and-a-half-year-old female spayed Great Dane was presented with a 2-month history of progressive swelling of the distal phalanx (PIII) of digits IV and V of the right pelvic limb. Eleven weeks prior to presentation, the dog had a low-grade cutaneous mast cell tumour completely excised from the craniolateral base of its left pinna. A history of trauma to 1 of the nails of the same pes 4 years prior to referral was also reported. Examination of the right pelvic limb identified firm non-painful swelling of PIII of digits IV and V, with concurrent deformation of the nails. Radiographs of the right pes obtained by the primary veterinarian identified an expansile lesion of PIII of digits IV and V. Computed tomography identified large expansile lesions of PIII of digits IV and V, with associated cortical thinning and soft tissue swelling. Neoplasia was considered the most likely radiographic diagnosis. Histopathology of Jamshidi bone biopsies was consistent with intraosseous epidermoid cyst, which was confirmed with immunohistochemistry. Amputation of PIII of digits IV and V at the level of mid-PII was performed as definitive treatment. No recurrence of the lesion occurred during the 10-month follow-up period.ConclusionsIntraosseous epidermoid cysts should be included in the differential diagnosis for expansile lesions affecting the canine digit. It is important to differentiate them from other digital lesions, with bone involvement, such as malignant digital tumours, which often require more extensive surgery for definitive treatment. The case herein highlights that this lesion can affect simultaneously multiple digits. Definitive diagnosis can be achieved by identification of keratin-producing epithelial cells on histopathology and confirmed by pancytokeratin labelling.
Value of metalloproteinases in predicting COPD in heavy urban smokers
Authors: Tsay Jun-Chieh J. , Hu Yingjie , Goldberg Judith D. , Wang Bin , Vijayalekshmy Soumya , Yie Ting-An , Bantis Katrina , Sterman Daniel H. , Rom William N. 
Published: September 2020

Abstract
Background
Emphysema in asymptomatic heavy smokers can be detected during CT-scan screening for lung cancer. Metalloproteinases (MMPs) have been found to play a role in the pathogenesis of chronic obstructive pulmonary disease and to possibly serve as biomarkers for emphysema.

Methods
The NYU Lung Cancer Biomarker Center enrolled study subjects over 50 years of age with lung cancer risk factors from January 1, 2010, to December 31, 2015. These subjects received chest multi-detector computed tomography, spirometry, and provided serum for immunoassays for metalloproteinases (MMP) -1, -2, -7, -9, -10 and tissue inhibitor of metalloproteinases (TIMP) -1 and -2.

Results
Three hundred sixteen study subjects were enrolled. Of the 222 patients who met the inclusion criteria, 46% had emphysema. Smokers with emphysema had increased pack-years of smoking compared to smokers without emphysema (51 ± 24 pack-years (mean ± sd) versus 37 ± 20; p < 0.0001). Smokers with emphysema also had lower FEV1/FVC percent compared to smokers without emphysema (68 ± 11 (mean ± sd) versus 75 ± 8; p < 0.0001). Increased age and pack-years of smoking were associated with increased odds of emphysema. None of the metalloproteinases or tissue inhibitors of metalloproteinases were useful to predict the presence of emphysema in smokers.

Conclusion
Emphysema was detected by CT in almost half of heavy urban smokers. Serum MMP levels provided minimal additional information to improve the detection of mild emphysema among smokers given their clinical characteristics (age, pack-years, and FEV1/FVC ratio).
Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets
Authors: Govindarajan Vaidya , de Rivero Vaccari Juan Pablo , Keane Robert W. 
Published: September 2020

AbstractMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be either destruction by autoimmune T cells or dysfunction of myelin-producing cells. Recent advances have indicated that inflammasomes contribute the etiology of MS. Inflammasomes are multiprotein complexes of the innate immune response involved in the processing of caspase-1, the activation of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as the cell death-mediated mechanism of pyroptosis and the activation of the adaptive immune response. Here we review the literature to date on the role of different inflammasome signaling pathways in the pathogenesis of MS and how these pathways may be targeted to reduce deleterious inflammatory processes and improve outcomes in this patient population.
An in-vitro evaluation of the flow haemodynamic performance of Gore-Tex extracardiac conduits for univentricular circulation
Authors: McHugo Shane , Nolke Lars , Delassus Patrick , MacCarthy Eugene , Morris Liam , McMahon Colin Joseph 
Published: September 2020

Abstract
Objective(s)
The Fontan procedure is a common palliative intervention for sufferers of single ventricle congenital heart defects that results in an anastomosis of the venous return to the pulmonary arteries called the total cavopulmonary connection (TCPC). In patients with palliated single ventricular heart defects, the Fontan circulation passively directs systemic venous return to the pulmonary circulation in the absence of a functional sub-pulmonary ventricle. Therefore, the Fontan circulation is highly dependent on favourable flow and energetics, and minimal energy loss is of great importance. The majority of in vitro studies, to date, employ a rigid TCPC model. Recently, few studies have incorporated flexible TCPC models, without the inclusion of commercially available conduits used in these surgical scenarios.

Method
The methodology set out in this study successfully utilizes patient-specific phantoms along with the corresponding flowrate waveforms to characterise the flow haemodynamic performance of extracardiac Gore-Tex conduits. This was achieved by comparing a rigid and flexible TCPC models against a flexible model with an integrated Gore-Tex conduit.

Results
The flexible model with the integrated Gore-Tex graft exhibited greater levels of energy losses when compared to the rigid walled model. With this, the flow fields showed greater levels of turbulence in the complaint and Gore-Tex models compared to the rigid model under ultrasound analysis.

Conclusion
This study shows that vessel compliance along with the incorporation of Gore-Tex extracardiac conduits have significant impact on the flow haemodynamics in a patient-specific surgical scenario.
Modelling email traffic workloads with RNN and LSTM models
Authors: Om Khandu , Boukoros Spyros , Nugaliyadde Anupiya , McGill Tanya , Dixon Michael , Koutsakis Polychronis , Wong Kok Wai 
Published: September 2020

AbstractAnalysis of time series data has been a challenging research subject for decades. Email traffic has recently been modelled as a time series function using a Recurrent Neural Network (RNN) and RNNs were shown to provide higher prediction accuracy than previous probabilistic models from the literature. Given the exponential rise of email workloads which need to be handled by email servers, in this paper we first present and discuss the literature on modelling email traffic. We then explain the advantages and limitations of different approaches as well as their points of agreement and disagreement. Finally, we present a comprehensive comparison between the performance of RNN and Long Short Term Memory (LSTM) models. Our experimental results demonstrate that both approaches can achieve high accuracy over four large datasets acquired from different universities’ servers, outperforming existing work, and show that the use of LSTM and RNN is very promising for modelling email traffic.
Non-destructive collection survey of the historical Classense Library. Part II: Conservation scenarios
Authors: Coppola Floriana , Brown Natalie , Amicucci Floriana , Strlič Matija , Modelli Alberto 
Published: September 2020

Abstract
The effects of environmental and conservation management scenarios on the permanence of the historical book collections housed at the Classense Library (Ravenna, Italy) were investigated. Non-destructive material surveys delivered paper pH and degree of polymerisation data that, in conjunction with the Collections Demography dose–response function, provide heritage managers with estimations of the predicted collection lifetimes in diverse environmental management scenarios. For the first time, quantitative measurements of paper properties obtained in a historical library collection were used to elaborate isochrone and demographic plots, evaluated against the long-term planning horizon of 500 years. The scenarios include preventive and interventive actions aiming to preserve the fitness-for-use of collection items in terms of their ability to withstand manual handling, and consider cooling, dehumidification and deacidification, as well as combinations thereof. The results inform the conservation decision-makers about the preservation outcomes of environmental management options, to be considered for further action, once environmental, economic and social sustainability of such scenarios is considered.
Vaginal cuff dehiscence following transvaginal oocyte retrieval: a case report
Authors: O’Connor Sarah K. , Ryley David A. , Obasiolu Charles W. , Esselen Katharine M. , Skiadas Christine C. , Kuohung Wendy 
Published: September 2020

Abstract
Background
Vaginal cuff dehiscence (VCD) is a rare but potentially serious complication following hysterectomy with an estimated incidence of 0.14–1.4%. There is a wide range of risk factors thought to contribute to VCD, but due to its rare occurrence, much still remains to be learned about the true impact of risk factors leading to dehiscence. We present here the second known report of VCD to occur in a patient undergoing transvaginal oocyte retrieval during her fertility treatment. This case highlights what may become a more common clinical scenario as more premenopausal women are diagnosed with reproductive tract cancers and access assisted reproductive therapies to preserve fertility.

Case presentation
Our patient is a 35-year-old G1 P0 A1 who had undergone ovary-sparing total laparoscopic hysterectomy (TLH) following diagnosis of endometrial adenocarcinoma. She underwent two in-vitro fertilization (IVF) cycles after TLH to bank frozen blastocysts, the first vaginal oocyte retrieval (VOR) taking place 12 weeks following hysterectomy. She experienced VCD during her second VOR that occurred 17 weeks after TLH, the second case of VCD to be reported in the literature during fertility preservation treatment following hysterectomy. The patient underwent an emergent and uncomplicated repair of the defect vaginally the same day.

Conclusions
Currently there are no guidelines in place for women who have undergone hysterectomy with regard to when they can begin fertility treatment in the post-operative period. Based on now two case reports, it is worth considering extension of the typical 6-week timeline of avoidance of vaginal procedures to allow for full cuff healing. Infertility providers should also be mindful of limiting transvaginal ultrasounds where possible to reduce force along the cuff.
Development and application of perfect SSR markers in cotton
Authors: WU Yuzhen , HUANG Longyu , ZHOU Dayun , FU Xiaoqiong , LI Chao , WEI Shoujun , PENG Jun , KUANG Meng 
Published: September 2020

Abstract
Background
This study aimed to develop a set of perfect simple sequence repeat (SSR) markers with a single copy in the cotton genome, to construct a DNA fingerprint database suitable for authentication of cotton cultivars. We optimized the polymerase chain reaction (PCR) system for multi-platform compatibility and improving detection efficiency. Based on the reference genome of upland cotton and 10× resequencing data of 48 basic cotton germplasm lines, single-copy polymorphic SSR sites were identified and developed as diploidization SSR markers. The SSR markers were detected by denaturing polyacrylamide gel electrophoresis (PAGE) for initial screening, then fluorescence capillary electrophoresis for secondary screening. The final perfect SSR markers were evaluated and verified using 210 lines from different sources among Chinese cotton regional trials.

Results
Using bioinformatics techniques, 1 246 SSR markers were designed from 26 626 single-copy SSR loci. Adopting a stepwise (primary and secondary) screening strategy, a set of 60 perfect SSR markers was selected with high amplification efficiency and stability, easy interpretation of peak type, multiple allelic variations, high polymorphism information content (PIC) value, uniform chromosome distribution, and single-copy characteristics. A multiplex PCR system was established with ten SSR markers using capillary electrophoresis detection.

Conclusions
A set of perfect SSR markers of cotton was developed and a high-throughput SSR marker detection system was established. This study lays a foundation for large-scale and standardized construction of a cotton DNA fingerprint database for authentication of cotton varieties.
Integrating art and science to communicate the social and ecological complexities of wildfire and climate change in Arizona, USA
Authors: Colavito Melanie , Satink Wolfson Barbara , Thode Andrea E. , Haffey Collin , Kimball Carolyn 
Published: September 2020

AbstractBackgroundThis paper describesFires of Change, a collaborative art exhibit designed to communicate about the shifting fire regimes of the United States Southwest through the lens of multimedia art. The Southwest Fire Science Consortium and Landscape Conservation Initiative, both of which are boundary organizations that facilitate collaboration among managers and scientists to develop and apply actionable science, organizedFires of Changeby convening scientists, managers, and artists in the co-production of science-based artwork. Surveys were conducted withFires of Changeexhibit visitors to assess the impacts of viewing the exhibit, as well as with exhibit creators to assess the effects of participating in the project.ResultsThe visitor survey results demonstrate thatFires of Changeexhibits increased visitors’ understanding of the effect of climate change on fire regimes and increased visitors’ support for management actions to address the effects of climate change on fire behavior. The exhibit creator survey results demonstrate that the development ofFires of Changecreated new relationships and networks among the participants and increased appreciation for collaborations among scientists, managers, and artists. Specifically, science-management relationships, networks, and boundary organizations may have facilitated the project.ConclusionsFires of Changedemonstrates that art can be an effective mechanism for communicating about complex ecological issues and that, by collaborating in the development of artwork, scientists and managers can create new partnerships.