bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ and rheumatologists’ perspectives on the efficacy and safety of low-dose glucocorticoids in rheumatoid arthritis—an international survey within the GLORIA study
Authors: Santiago T , Voshaar M , de Wit M , Carvalho P D , Buttgereit F , Cutolo M , Paolino S   , Castelar Pinheiro G R , Boers M , Da Silva J A P 
Published: November 2020

AbstractObjectiveTo evaluate the current perspectives of patients and health professionals regarding the efficacy and safety of low-dose glucocorticoids (GCs) in RA.MethodsTwo online surveys were disseminated to patients and health professionals, in their native language, through national patient organizations and national rheumatology medical societies, respectively. SurveyMonkey®, MediGuard.org and the Glucocorticoid Low-dose Outcome in RA Study (GLORIA) website were used to offer and deliver these surveys.ResultsA total of 1221 RA patients with exposure to GCs, and 414 rheumatologists completed the surveys. Patients and rheumatologists reported high levels of agreement regarding the efficacy of low-dose GCs: at least 70% considered that they are very rapid and effective in the control of signs and symptoms of RA. However, half of the patients also reported having suffered serious adverse events with GCs, and 83% described concerns about safety. The majority of rheumatologists estimated that endocrine, ophthalmologic and cutaneous adverse events affect &gt;4% of all patients treated with low-dose GCs for 2 years, based on a heat map.ConclusionsRA patients with self-reported exposure to GCs express high levels of satisfaction with low-dose GCs efficacy, as do rheumatologists. However, both expressed excessive concerns regarding the safety of GCs (greatly exceeding the published evidence data), which may compromise the optimal use of this medication. This study indicates that there is an unmet need for appropriately designed prospective trials that shed light on the real risk associated with low-dose GCs, as well as a need for renovated educational programs on the real benefits and harms of low-dose GCs, for both patients and physicians.
Residual, differential neurobehavioral deficits linger after multiple recovery nights following chronic sleep restriction or acute total sleep deprivation
Authors: Yamazaki Erika M , Antler Caroline A , Lasek Charlotte R , Goel Namni 
Published: November 2020

Abstract

Study Objectives
The amount of recovery sleep needed to fully restore well-established neurobehavioral deficits from sleep loss remains unknown, as does whether the recovery pattern differs across measures after total sleep deprivation (TSD) and chronic sleep restriction (SR).

Methods
In total, 83 adults received two baseline nights (10–12-hour time in bed [TIB]) followed by five 4-hour TIB SR nights or 36-hour TSD and four recovery nights (R1–R4; 12-hour TIB). Neurobehavioral tests were completed every 2 hours during wakefulness and a Maintenance of Wakefulness Test measured physiological sleepiness. Polysomnography was collected on B2, R1, and R4 nights.

Results
TSD and SR produced significant deficits in cognitive performance, increases in self-reported sleepiness and fatigue, decreases in vigor, and increases in physiological sleepiness. Neurobehavioral recovery from SR occurred after R1 and was maintained for all measures except Psychomotor Vigilance Test (PVT) lapses and response speed, which failed to completely recover. Neurobehavioral recovery from TSD occurred after R1 and was maintained for all cognitive and self-reported measures, except for vigor. After TSD and SR, R1 recovery sleep was longer and of higher efficiency and better quality than R4 recovery sleep.

Conclusions
PVT impairments from SR failed to reverse completely; by contrast, vigor did not recover after TSD; all other deficits were reversed after sleep loss. These results suggest that TSD and SR induce sustained, differential biological, physiological, and/or neural changes, which remarkably are not reversed with chronic, long-duration recovery sleep. Our findings have critical implications for the population at large and for military and health professionals.
A pilot trial of a transdiagnostic treatment for emotional disorders—a locally adapted variant of group Unified Protocol (UP) for Chinese adults
Authors: Powell Candice L Y M , Farchione Todd J , Barlow David H , Leung Patrick W L 
Published: November 2020

Abstract
There has been increasing interest in transdiagnostic cognitive-behavioral therapy (CBT), which is more cost efficient yet yields similar effect sizes when compared to disorder-specific CBT. The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders was adapted for Hong Kong Chinese adults with common mental disorders, such as depression and anxiety. It was piloted in community settings and delivered in a group format. Thirty-one Chinese adults (female = 93.5%, mean age = 44 years) with heterogeneous anxiety and depressive disorders were recruited from a number of public-funded community mental health centers in Hong Kong to participate in a pilot trial of a locally adapted variant of UP. Treatment consisted of 14 group sessions plus one individual session. Each group included six to nine participants. The diagnostic and outcome measures included Anxiety Disorders Interview Schedule for DSM-IV, The Chinese versions of Beck Depression Inventory-Revised (C-BDI-II), Beck Anxiety Inventory (C-BAI), Positive Affect subscale of Positive and Negative Affect Scale, and Work and Social Adjustment Scale. Results indicate significant improvement across a number of outcome measures, with moderate-to-large effect sizes for measures of depression (d = 1.11), anxiety (d = 0.67), positive affect (d = 0.54), and work and social functioning (d = 0.49). Furthermore, 45.2% and 29.0% of the participants scored within the normal range of C-BDI-II and C-BAI at posttreatment, respectively, compared to 3.2% and 6.5% at pretreatment. This pilot, uncontrolled trial demonstrated potential effectiveness of a locally adapted variant of group UP for Chinese adults with common mental disorders. It achieved comparable effect sizes to those observed in western populations.
European Consumer Law after the New Deal: A Tryptich
Authors: Grochowski Mateusz 
Published: November 2020

Abstract
In 2018/2019, EU private law experienced one of the most vigorous and meaningful changes in its evolution so far. The prominence of this alteration does not rest solely on the number of new rules, but—more importantly—on the substantially new perspective on economic and social tasks of European private law. The reform encompassed three core areas: consumer protection, sustainability and digital commerce. The paper seeks to better understand the transformative task of private law in the social and economic realm. The protection of the environment, on the one hand, and the informational autonomy and privacy, on the other, provide a new type of challenge for the existing agenda of private law, reaching beyond economic efficiency as its ultimate goal. Finally, the emergence of digitalization and sustainability as the new domains of private law reinvigorates the question of to what extent the European private law should directly engage itself in pursuing the social and economic agenda. The 2018/2019 legislation opened a new chapter in this discussion, facing private law with a new genre of tasks, which traditionally belonged to the domain of public ordering. The paper seeks to unpack the essence of this change by focusing on three intertwined issues: vulnerability, autonomy, and regulation. Mingled together they seem to form the backbone of the reform, which seems to provide an in-depth subversion of the existing conceptual structures of EU consumer law.
Parallel evolution of toepads in rock-dwelling lineages of a terrestrial gecko (Gekkota: Gekkonidae:Heteronotia binoei)
Authors: Riedel Jendrian , Zozaya Stephen M , Hoskin Conrad J , Schwarzkopf Lin 
Published: November 2020

AbstractSelection for effective locomotion can lead to specialized morphological structures. Adhesive toepads, which have arisen independently in different lizard clades, facilitate the use of vertical and inverted substrates. Their evolution is poorly understood because functionally intermediate morphological configurations between padless and pad-bearing forms are rare. To shed light on toepad evolution, we assessed the subdigital morphology of phylogenetically distinct lineages of the Bynoe’s gecko species complex (Heteronotia binoei). Most populations of H. binoei are terrestrial, but two relatively distantly related saxicoline (rock-dwelling) lineages have enlarged terminal subdigital scales resembling toepads. We reconstructed the ancestral terminal subdigital scale size of nine lineages of H. binoei in eastern Australia, including these two saxicoline lineages. Additionally, we compared the subdigital microstructures of four lineages: the two saxicoline lineages and their respective terrestrial sister-lineages. Surprisingly, all four lineages had fully developed setae, but the setae of the two saxicoline lineages were significantly longer, branched more often and were more widely spaced than the terrestrial sister-lineages. We conclude that the saxicoline lineages represent examples of parallel evolution of enlarged adhesive structures in response to vertical substrate use, and their morphology represents a useful model as an intermediate state in toepad evolution.
Molecular phylogeny of the Orthurethra (Panpulmonata: Stylommatophora)
Authors: Saadi Ahmed J , Mordan Peter B , Wade Christopher M 
Published: November 2020

AbstractWe have undertaken a molecular analysis of the Orthurethra, one of the major groups of stylommatophoran land snails and slugs. Approximately 4000 nucleotides of the rRNA gene cluster [5.8S, internal transcribed spacer 2 (ITS2) and almost the full-length large subunit (LSU; 28S) gene] were sequenced for 40 orthurethran genera belonging to 19 families. Our phylogeny recovers three well-supported clades within the Orthurethra; the Azecidae, Chondrinidae + Truncatellinidae, and a main clade comprising all remaining orthurethran families. The first division in the Orthurethra separates the Azecidae from all other orthurethran taxa. Of those families represented by more than one genus, the Achatinellidae, Azecidae, Cerastidae, Partulidae and Vertiginidae are recovered as strongly supported monophyletic units, whereas the Chondrinidae, Enidae, Pupillidae and Valloniidae are unsupported in the tree. Although there is relatively little support for the deep-level relationships among the main orthurethran groups, some groupings are strongly supported. The sister-group relationship of the Cochlicopidae with the Amastridae is strongly supported in our molecular analyses, and there is also some support for the grouping of the Orculidae with the Pyramidulidae, and the Draparnaudiidae with the Gastrocoptidae. The findings of our molecular analyses support dividing the Orthurethra into three superfamilies: the Azecoidea, Chondrinoidea and Pupilloidea.
Causal inference gates corticostriatal learning
Authors: Dorfman Hayley M. , Tomov Momchil , Cheung Bernice , Clarke Dennis , Gershman Samuel J. , Hughes Brent L. 
Published: November 2020

AbstractAttributing outcomes to your own actions or to external causes is essential for appropriately learning which actions lead to reward and which actions do not. Our previous work showed that this type of credit assignment is best explained by a Bayesian reinforcement learning model which posits that beliefs about the causal structure of the environment modulate reward prediction errors (RPEs) during action value updating. In this study, we investigated the neural circuits underlying reinforcement learning that are influenced by causal beliefs using functional magnetic resonance imaging (fMRI) while human participants (N = 31; 13 males, 18 females) completed a behavioral task that manipulated beliefs about causal structure. We found evidence that RPEs modulated by causal beliefs are represented in posterior putamen, while standard (unmodulated) RPEs are represented in ventral striatum. Further analyses revealed that beliefs about causal structure are represented in anterior insula and inferior frontal gyrus. Finally, structural equation modeling revealed effective connectivity from anterior insula to posterior putamen. Together, these results are consistent with a neural architecture in which causal beliefs in anterior insula are integrated with prediction error signals in posterior putamen to update action values.Significance StatementLearning which actions lead to reward – a process known as reinforcement learning – is essential for survival. Inferring the causes of observed outcomes – a process known as causal inference – is crucial for appropriately assigning credit to one’s own actions and restricting learning to effective action-outcome contingencies. Previous studies have linked reinforcement learning to the striatum and causal inference to prefrontal regions, yet how these neural processes interact to guide adaptive behavior remains poorly understood. Here, we found evidence that causal beliefs represented in the prefrontal cortex modulate action value updating in posterior striatum, separately from the unmodulated action value update in ventral striatum posited by standard reinforcement learning models.
Quantification of Hypoperfusion in Autism Assessed by Diffuse Correlation Spectroscopy and Frequency Domain Near Infrared Spectroscopy
Authors: Rinehart Benjamin , Poon Chien-Sing , Sunar Ulas 
Published: November 2020

AbstractThere is a need for quantitative biomarkers for early diagnosis of autism. We showed previously that hemoglobin concentrations show contrast between autistic group vs control group in humans. Cerebral blood flow can provide additional sensitivity for improved characterization. Diffuse correlation spectroscopy (DCS) has been shown to be reliable method to obtain blood flow contrast in animals and humans. Thus, in this study we evaluated DCS in an established autism model. Our results indicate that autistic group had significantly lower blood flow compared to control group. These results confirm the previous results obtained from humans by positron emission tomography and magnetic resonance imaging.
Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling
Authors: Markworth James F. , Brown Lemuel A. , Lim Eunice , Castor-Macias Jesus A. , Larouche Jacqueline , Macpherson Peter C. D. , Davis Carol , Aguilar Carlos A. , Maddipati Krishna Rao , Brooks Susan V. 
Published: November 2020

AbstractChronic inflammation and deregulated acute immune cell responses to injury contribute to age-associated skeletal muscle dysfunction. Specialized pro-resolving mediators (SPMs) control inflammation and support myofiber regeneration in young mice, but their role in aging muscle remains unknown. Here we examined the effect of age on the mediator lipidome of skeletal muscle via LC-MS based lipidomic profiling and tested whether systemic administration of the SPM resolvin D1 (RvD1) could limit excessive inflammation and improve the regenerative capacity of aged muscle. Aged mice displayed chronic low-grade muscle inflammation prior to injury and this was associated with a basal deficiency of lipoxygenase (LOX) derived SPMs as well as anti-inflammatory cytochrome P450 (CYP) derived lipid epoxides. Following muscle damage, young and aged mice produced similar amounts of pro-inflammatory cyclooxygenase (COX) and 12-LOX metabolites, but aged mice mounted a markedly deficient SPM response. This was associated with heightened leukocyte recruitment, impaired myofiber regeneration, and delayed recovery of strength. Systemic treatment with RvD1 had minimal impact on excessive myeloid cell infiltration and defective myofiber regeneration in aged mice. Nevertheless, RvD1 treatment did suppress inflammatory cytokines, modulated muscle stem cells, limited maladaptive tissue remodeling, and improved recovery of specific muscle force. We conclude that aging results in a marked deficiency of local SPM biosynthesis within muscle and that immunoresolvents may be attractive novel therapeutics for the treatment of muscular injuries and associated pain in the elderly, due to positive effects on recovery of muscle function without the negative side effects on myofiber regeneration of traditional anti-inflammatory treatments.
Conserved visual capacity of rats under red light
Authors: Nikbakht Nader , Diamond Mathew E. 
Published: November 2020

AbstractRecent studies examine the behavioral capacities of rats and mice with and without visual input, and the neuronal mechanisms underlying such capacities. These animals are assumed to be functionally blind under red light, an assumption that might originate in the fact that they are dichromats who possess ultraviolet and green but not red cones. But the inability to see red as a color does not necessarily rule out form vision based on red light absorption. We measured Long-Evans rats’ capacity for visual form discrimination under red light of various wavelength bands. Upon viewing a black and white grating, they had to distinguish between two categories of orientation, horizontal and vertical. Psychometric curves plotting judged orientation versus angle demonstrate the conserved visual capacity of rats under red light. Investigations aiming to explore rodent physiological and behavioral functions in the absence of visual input should not assume red-light blindness.
Characterization of the complete mitochondrial genome of the New Zealand parasitic blowflyCalliphora vicina(Insecta: Diptera: Calliphoridae)
Authors: Palevich Nikola , Carvalho Luis , Maclean Paul 
Published: November 2020

ABSTRACTIn the present study, the complete mitochondrial genome of the New Zealand parasitic blowflyCalliphora vicina(blue bottle blowfly) field strain NZ_CalVic_NP was generated using next-generation sequencing technology and annotated. The 16,518 bp mitochondrial genome consists of 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, and a 1,689 bp non-coding region, similar to most metazoan mitochondrial genomes. Phylogenetic analysis showed thatC. vicinaNZ_CalVic_NP does not form a monophyletic cluster with the remaining three Calliphorinae species. The complete mitochondrial genome sequence ofC. vicinaNZ_CalVic_NP is a resource to facilitate future species identification research within the Calliphoridae.
High-Throughput Image-Based Plant Stand Count Estimation Using Convolutional Neural Networks
Authors: Khaki Saeed , Pham Hieu , Han Ye , Kent Wade , Wang Lizhi 
Published: November 2020

AbstractThe future landscape of modern farming and plant breeding is rapidly changing due to the complex needs of our society. The explosion of collectable data has started a revolution in agriculture to the point where innovation must occur. To a commercial organization, the accurate and efficient collection of information is necessary to ensure that optimal decisions are made at key points of the breeding cycle. However, due to the sheer size of a breeding program and current resource limitations, the ability to collect precise data on individual plants is not possible. In particular, efficient phenotyping of crops to record its color, shape, chemical properties, disease susceptibility, etc. is severely limited due to labor requirements and, oftentimes, expert domain knowledge. In this paper, we propose a deep learning based approach, named DeepStand, for image-based corn stand counting at early phenological stages. The proposed method adopts a truncated VGG-16 network as a backbone feature extractor and merges multiple feature maps with different scales to make the network robust against scale variation. Our extensive computational experiments suggest that our proposed method can successfully count corn stands and out-perform other state-of-the-art methods. It is the goal of our work to be used by the larger agricultural community as a way to enable high-throughput phenotyping without the use of extensive time and labor requirements.
A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
Authors: Ma Wen-Juan , Pannebakker Bart A. , Li Xuan , Geuverink Elzemiek , Anvar Seyed Yahya , Veltsos Paris , Schwander Tanja , van de Zande Louis , Beukeboom Leo W. 
Published: November 2020

AbstractDuring the transition from sexual to asexual reproduction, a suite of reproduction-related sexual traits become superfluous, and may be selected against if costly. Female functional virginity refers to asexual females resisting to mate or not fertilizing eggs after mating. These traits appear to be among the first that evolve during the gradual transition from sexual to asexual reproduction. The genetic basis of female functional virginity remains elusive. Previously, we reported that female functional virginity segregates as a single recessive locus in the asexual parasitoid waspAsobara japonica. Here, we investigate the genetic basis of this trait by quantitative trait loci (QTL) mapping and candidate gene analyses. Consistent with the segregation of phenotypes, a single QTL of large effect was found spanning over 4.23 Mb and comprising at least 131 protein-coding genes, of which 15 featured sex-biased expression in the related sexualAsobara tabida. We speculate that two of these 15 genes may be of particular interest:CD151 antigenandnuclear pore complex protein Nup50. Overall, our results are consistent with a single gene or a cluster of linked genes underlying rapid evolution of female functional virginity in the transition to asexuality. Once a mutation for rejection to mate has swept through a population, the region comprising the gene(s) does not get smaller due to lack of recombination in asexuals.