bluuebunny/crossref_metadata_2025_split huggingface dataset:
One Health Aotearoa: a transdisciplinary initiative to improve human, animal and environmental health in New Zealand
Authors: Harrison Sarah , Baker Michael G. , Benschop Jackie , Death Russell G. , French Nigel P. , Harmsworth Garth , Lake Robin J. , Lamont Iain L. , Priest Patricia C. , Ussher James E. , Murdoch David R. 
Published: January 2020

AbstractThere is increased recognition that complex health challenges at the human-animal-environmental interface require a transdisciplinary, “whole-of-society” approach. This philosophy is particularly pertinent in Aotearoa-New Zealand because of the country’s relatively isolated island ecosystem, economic reliance on agriculture and its intensification, and existing indigenous worldview that emphasises holism and interconnectivity between humans, animals and the environment. In New Zealand, the One Health Aotearoa (OHA) alliance was established in order to better connect researchers and to address a growing number of infectious diseases challenges. The emphasis of OHA is to bring together and facilitate interactions between people from diverse disciplines, link to stakeholders and communities, and engage with policy-makers, government operational agencies, and funders, thus providing a holistic and integrative systems-thinking approach to address priority questions and achieve desired outcomes in One Health. The initial focus of OHA has been on infectious diseases, but there is increasing recognition of the potential benefits of the alliance to address broader complex issues. Greater involvement and overlap of the environmental sciences, human and animal health sciences, social science, and indigenous kaupapa Māori research is particularly critical for ensuring its success within the New Zealand context. Given the economic and cultural importance of New Zealand’s “clean, green” image, a One Health approach that draws strongly on the environmental sciences makes particular sense. Furthermore, as the global environment becomes increasingly stressed by anthropogenic pressures our research may hold potential solutions for similar challenges elsewhere.
Brain and pain: old assumptions and new science about chronic pain
Authors: Ikkos George , Ramanuj Parashar Pravin 
Published: January 2020

SUMMARYThe authors summarise the evolving understanding of the neuropsychophysiology of chronic pain, including the relevance of adverse childhood experiences in facilitating it and similarities between the central physiology of chronic pain and opioid addiction. Emerging understanding highlights the importance of dopamine-expressing GABAergic neurons in the nucleus accumbens and suggests that D1 expression is associated with a sense of pleasure and approach behaviour and D2 with a sense of punishment and behavioural inhibition. Regulation of D1 and D2 expression may be mediated by nigrostriatal and medial frontal striatal pathways within the increasingly understood brain as a ‘predictive’ organ. The distinction between the predictive brain and personal ‘expectations’ and the importance of the latter for clinical outcomes are emphasised. The relevance of findings for possible future psychopharmacological treatment avenues is also presented.
Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder
Authors: van Haren Neeltje E.M. , Setiaman Nikita , Koevoets Martijn G.J.C. , Baalbergen Heleen , Kahn Rene S. , Hillegers Manon H.J. 
Published: January 2020

AbstractBackground.Studying offspring of schizophrenia (SZo) and bipolar disorder patients (BDo) provides important information on the putative neurodevelopmental trajectories underlying development toward severe mental illnesses. We compared intracranial volume (ICV), as a marker for neurodevelopment, and global and local brain measures between SZo or BDo and control offspring (Co) in relation to IQ and psychopathology.Methods.T1-weighted magnetic resonance imaging (MRI) brain scans were obtained from 146 participants (8–19 years; 40 SZo, 66 BDo, 40 Co). Linear mixed models were applied to compare ICV, global, and local brain measures between groups. To investigate the effect of ICV, IQ (four subtests Wechsler Intelligence Scale for Children/Wechsler Adult Intelligence Scale-III) or presence of psychopathology these variables were each added to the model.Results.SZo and BDo had significantly lower IQ and more often met criteria for a lifetime psychiatric disorder than Co. ICV was significantly smaller in SZo than in BDo (d= −0.56) and Co (d= −0.59), which was largely independent of IQ (respectively,d= −0.54 andd= −0.35). After ICV correction, the cortex was significantly thinner in SZo than in BDo (d= −0.42) and Co (d= −0.75) and lateral ventricles were larger in BDo than in Co (d= 0.55). Correction for IQ or lifetime psychiatric diagnosis did not change these findings.Conclusions.Despite sharing a lower IQ and a higher prevalence of psychiatric disorders, brain abnormalities in BDo appear less pronounced (but are not absent) than in SZo. Lower ICV in SZo implies that familial risk for schizophrenia has a stronger association with stunted early brain development than familial risk for bipolar disorder.
Cannabis use and nonuse in patients with first-episode psychosis: A systematic review and meta-analysis of studies comparing neurocognitive functioning
Authors: Sánchez-Gutiérrez Teresa , Fernandez-Castilla Belén , Barbeito Sara , González-Pinto Ana , Becerra-García Juan Antonio , Calvo Ana 
Published: January 2020

AbstractBackground.The implications of cannabis use in the onset of early psychosis and the severity of psychotic symptoms have resulted in a proliferation of studies on this issue. However, few have examined the effects of cannabis use on the cognitive symptoms of psychosis (i.e., neurocognitive functioning) in patients with first-episode psychosis (FEP). This systematic review and meta-analysis aim to assess the neurocognitive functioning of cannabis users (CU) and nonusers (NU) with FEP.Methods.Of the 110 studies identified through the systematic review of 6 databases, 7 met the inclusion criteria, resulting in 14 independent samples and 78 effect sizes. The total sample included 304 CU with FEP and 369 NU with FEP. The moderator variables were age at first use, duration of use, percentage of males, and age.Results.Effect sizes were not significantly different from zero in any neurocognitive domain when users and NU were compared. Part of the variability in effect sizes was explained by the inclusion of the following moderator variables: (1) frequency of cannabis use (β= 0.013,F= 7.56,p= 0.017); (2) first-generation antipsychotics (β= 0.019,F= 34.46,p≤ 0.001); and (3) country where the study was carried out (β= 0.266,t= 2.06,p= 0.043).Conclusions.This meta-analysis indicates that cannabis use is not generally associated with neurocognitive functioning in patients with FEP. However, it highlights the deleterious effect of low doses of cannabis in some patients. It also stresses the importance of the type of antipsychotic prescription and cannabis dose as moderator variables in the neurocognitive functioning of CU with FEP.
Urinary Norepinephrine Is a Metabolic Determinant of 24-Hour Energy Expenditure and Sleeping Metabolic Rate in Adult Humans
Authors: Hollstein Tim , Basolo Alessio , Ando Takafumi , Votruba Susanne B , Krakoff Jonathan , Piaggi Paolo 
Published: January 2020

AbstractBackgroundInterindividual variability in 24-hour energy expenditure (24EE) during energy-balance conditions is mainly determined by differences in body composition and demographic factors. Previous studies suggested that 24EE might also be influenced by sympathetic nervous system activity via catecholamine (norepinephrine, epinephrine) secretion. Therefore, we analyzed the association between catecholamines and energy expenditure in 202 individuals from a heterogeneous population of mixed ethnicities.MethodsParticipants (n = 202, 33% female, 14% black, 32% white, 41% Native American, 11% Hispanic, age: 36.9 ± 10.3 y [mean ± SD], percentage body fat: 30.3 ± 9.4) resided in a whole-room calorimeter over 24 hours during carefully controlled energy-balance conditions to measure 24EE and its components: sleeping metabolic rate (SMR), awake-fed thermogenesis (AFT), and spontaneous physical activity (SPA). Urine samples were collected, and 24-h urinary epinephrine and norepinephrine excretion rates were assessed by high-performance liquid chromatography.ResultsBoth catecholamines were associated with 24EE and SMR (norepinephrine: +27 and +19 kcal/d per 10 μg/24h; epinephrine: +18 and +10 kcal/d per 1 μg/24h) in separate analyses after adjustment for age, sex, ethnicity, fat mass, fat-free mass, calorimeter room, temperature, and physical activity. In a multivariate model including both norepinephrine and epinephrine, only norepinephrine was independently associated with both 24EE and SMR (both P &lt; .008), whereas epinephrine became insignificant. Neither epinephrine nor norepinephrine were associated with adjusted AFT (both P = .37) but epinephrine was associated with adjusted SPA (+0.5% per 1 μg/24h).ConclusionsOur data provide compelling evidence that sympathetic nervous system activity, mediated via norepinephrine, is a determinant of human energy expenditure during nonstressed, eucaloric conditions.
Pitfalls in the beam modelling process of Monte Carlo calculations for proton pencil beam scanning
Authors: Winterhalter Carla , Aitkenhead Adam , Oxley David , Richardson Jenny , Weber Damien C. , MacKay Ranald I. , Lomax Antony J. , Safai Sairos 
Published: January 2020

Objective:
Monte Carlo (MC) simulations substantially improve the accuracy of predicted doses. This study aims to determine and quantify the uncertainties of setting up such a MC system.

Methods:
Doses simulated with two Geant4-based MC calculation codes, but independently tuned to the same beam data, have been compared. Different methods of MC modelling of a pre-absorber have been employed, either modifying the beam source parameters (descriptive) or adding the pre-absorber as a physical component (physical).

Results:
After the independent beam modelling of both systems in water (resulting in excellent range agreement) range differences of up to 3.6/4.8 mm (1.5% of total range) in bone/brain-like tissues were found, which resulted from the use of different mean water ionisation potentials during the energy tuning process. When repeating using a common definition of water, ranges in bone/brain agreed within 0.1 mm and gamma-analysis (global 1%,1mm) showed excellent agreement (&gt;93%) for all patient fields. However, due to a lack of modelling of proton fluence loss in the descriptive pre-absorber, differences of 7% in absolute dose between the pre-absorber definitions were found.

Conclusion:
This study quantifies the influence of using different water ionisation potentials during the MC beam modelling process. Furthermore, when using a descriptive pre-absorber model, additional Faraday cup or ionisation chamber measurements with pre-absorber are necessary.

Advances in knowledge:
This is the first study quantifying the uncertainties caused by the MC beam modelling process for proton pencil beam scanning, and a more detailed beam modelling process for MC simulations is proposed to minimise the influence of critical parameters.
What are the outcomes of core decompression in patients with avascular necrosis? Protocol for a systematic review
Authors: Andronic Octavian , Shoman Haitham , Weiss Ori , Khanduja Vikas 
Published: January 2020

Background: Core decompression is a hip preserving surgical procedure that is used to treat avascular necrosis (AVN) of the femoral head. The eventual clinical and radiological outcome following this procedure is varied in literature. Also, the time to a total hip replacement (THR) from the index procedure and the percentage of patients subsequently undergoing a THR is controversial. Furthermore, there are multiple surgical methods along with multiple augmentation techniques and various classification and staging systems described. The purpose of this systematic review, therefore, is to analyse the outcomes following decompression only, excluding any augmentation techniques for non-traumatic AVN of the femoral head. Methods: This protocol is being developed in line with the PRISMA-P guidelines. The search strategy includes articles from Medline, Embase, Google Scholar, CINHAL and Cochrane library. The review and screening will be done by two independent reviewers. Review articles, editorials and correspondences will be excluded. Articles including patients with sickle cell disease and with core decompression where augmentation is used will be excluded. The risk of bias and quality of articles will be assessed using the Joanna Briggs Institute Critical Appraisal Checklist for the different study designs included. Discussion: This study will be a comprehensive review on all published articles having patients with AVN of the femoral head and undergoing core decompression surgery only. The systematic review will then define the outcomes of the core decompression surgery based on clinical and radiological outcomes. Each outcome will include the different stages within it and finally, the total mean time to THR will be calculated. This will then be followed by assessing the cumulative confidence in evidence from all the data collected using the GRADE tool. Registration: This systematic review is registered in the International Prospective Register for Systematic Reviews and Meta-analysis (PROSPERO) under the registration number: CRD42018100596
Electron number density conservation model combined with a self-absorption correction methodology for analysis of nanostructure plasma using laser-induced breakdown spectroscopy
Authors: Farooq Zahid , Ali Raheel , Ahmad Aqrab ul , Yaseen M. , Mahmood Mian H. R. , Fahad M. , Hussain M. Nasir , Rehan I. , Khan M. Zubair , Ramiza  , Farooq M. Umer , Qayyum M. Abdul , Shafique M. 
Published: January 2020

We studied laser ablation and plasma property evolution for a nickel (Ni) doped tin (Sn) oxide nanostructures target using laser-induced breakdown spectroscopy (LIBS). The transition metal Ni doped tin oxide nanostructures were synthesized by co-precipitation and hydrothermal methodologies. The size of prepared nanoparticles was verified by X-ray diffraction and transmission electron microscopy techniques. A frequency-doubled pulsed Nd:YAG laser with a wavelength of 532 nm was used to produce ablated plasma nanostructures. Ablation of doped and undoped nanostructures revealed salient-enhanced spectral emissions compared with their bulky counterparts. The emission lines of the constituent elements of doped material were used to find plasma parameters. The plasma temperature was estimated from a Boltzmann plot, and the electron number density was determined from the Saha–Boltzmann equation. The self-absorption effect has been observed in tiny plasma of nanostructures. The affected profiles of spectral lines of Ni and Sn nanoparticles due to self-absorption in LIBS spectra were corrected by the internal reference self-absorption correction (IRSAC) methodology. After correction of emitted line intensities by IRSAC, the electron number density (END) conservation approach was applied for quantitative analysis of doped nanostructures. In the END conservation approach, quantitative analysis of samples was carried out using electron number densities. Quantitative results derived from the END conservation approach at high and low concentrations exhibited good correlation when these were compared and validated with results from a conventional calibration free approach and the standard recognized energy dispersive X-ray technique.
TOCOPHEROLS OF FRUIT PULP OF FOUR SEABUCKTHORN (HIPPOPHAE RHAMNOIDES L.) SUBSPECIES IN FOREST-STEPPE CONDITIONS OF ALTAI TERRITORY
Authors: Земцова (Zemtsova) Анна (Anna) Яковлевна (Yakovlevna) , Зубарев (Zubarev) Юрий (Yuriy) Анатольевич (Anatol'evich) , Гунин (Gunin) Алексей (Aleksey) Васильевич (Vasil'evich) 
Published: January 2020

The aim of the study was to study tocopherols in the fruits of various sea buckthorn ecotypes ssp. mongolica in comparison with other subspecies. The composition of tocopherols in fruit pulp of four subspecies of sea buckthorn – H. rhamnoides ssp. mongolica, ssp. turkestanica, ssp. fluviatilis and ssp. carpatica, growing at Lisavenko Research Institute of Horticulture for Siberia in forest-steppe conditions of Altai territory has been studied. The research has been focused on the most promising subspecies from the point of view of industrial utilization – H. rhamnoides ssp. mongolica, in order to identify possible variation in accumulation of different tocopherols in fruit pulp depending on ecotype, period of collection of fruits as well as conditions of the year.
It was established that the major tocopherol in the pulp of the fruit of sea buckthorn is α-tocopherol. β -, γ-and δ-tocopherols were characterized by low content. Within subspecies H. rhamnoides ssp. mongolica most fractions of tocopherols (except δ-tocopherol) have relatively high coefficient of variation, which exceeds of that for the whole group of evaluated varieties. That result does not allow us to use this criteria as a reliable background for preliminary systematic identification of evaluated varieties.
Evaluation of marginal fit and microleakage of monolithic zirconia crowns cemented by bio-active and glass ionomer cements: In vitro study
Authors: Aboelenen Radwa Hamdy , Mokhtar Ashraf , Zaghloul Hanaa 
Published: January 2020

Objective: To evaluate the marginal fit and microleakage of monolithic zirconia crowns cemented with bioactive cement (Ceramir) compared to that cemented with glass ionomer cement and to evaluate the effect of thermocycling on marginal fit. Materials and methods: Twenty sound human molar teeth were prepared to receive a monolithic zirconia crowns. Teeth were divided randomly into two equal groups according to the type of luting cement. Group I: glass ionomer cement and group II: Ceramir cement. After cementation, the vertical marginal gap was assessed by using stereomicroscope before and after thermocycling. Twenty equidistant measurement points were taken for each crown. Leakage assessment was carried out using Fuchsin dye penetration followed by digital photography under a stereomicroscope. Data were analyzed by Mann-Whitney U test to compare between the two luting cements. Wilcoxon signed-rank test was used to evaluate the effect of thermocycling on the marginal fit (P ? 0.05)?Results: Whether before or after thermocycling, the results showed no significant difference between the marginal gap values of the two tested groups. For both groups, there was a significant increase in marginal gap values after thermocycling. Also, there was no significant difference between leakage scores of the two tested groups. Conclusions: Similarity in the physical properties and chemical composition of the two cements result in a non- significant effect on the vertical marginal fit and the extent of microleakage of translucent zirconia crowns. Thermocycling had a negative impact on the vertical marginal gap of the two tested luting agents.
Micro-shear bond strength of bioactive cement to translucent zirconia after thermocycyling: a comparative in-vitro study
Authors: ElGendy Menna Ahmed , Mosleh Ihab , Zaghloul Hanaa 
Published: January 2020

Objective: the purpose of the study was to evaluate the micro-shear bond strength of different cements to translucent zirconia before and after thermocycling aging. Material and methods: Twelve translucent zirconia ceramic discs were used in the study. Specimens were sandblasted using 50 ??m aluminum oxide (Al2O3) particles. The specimens were divided into three groups (n = 4) according to the cement type: Panavia resin cement (control group), resin modified glass ionomer (RMGI), and Activa bioactive cement. Each group was further sub-divided into two equal subgroups (n = 2) according to whether the specimens were subjected to thermocycling or not. Thermocycling was performed in distilled water at 5000 cycles between 5 oC - 55 oC. The micro-shear bond strength test (?SBS) was measured using universal testing machine. Kruskal-Wallis test was used to compare between the three cements. Dunn’s test was used for pair-wise comparisons when Kruskal-Wallis test is significant. Mann-Whitney U test was used to compare between micro-shear bond strength before and after thermocycling P ? 0.05. Results: In non-aged subgroups, there was no significant difference between Panavia and Activa; both showed significantly the highest mean ?SBS values (22.9 MPa, 31.3 MPa respectively). While, RMGI showed the lowest ?SBS values (4.7 MPa). In thermocycled subgroups, Panavia showed significantly the highest mean ?SBS values (32.2 MPa). There was no significant difference between RMGI and Activa; both showed the lowest significant mean ?SBS values (3.2 MPa and 8.7 MPa respectively). Conclusions: RMGI and Activa couldn’t be considered long-term reliable materials for cementing zirconia. However, Panavia provided the most durable bond to zirconia.KEYWORDSBioactive cement; Micro-shear bond strength; Resin cement; Translucent zirconia.
Esthetic perception regarding periodontal changes: a crosssectional study
Authors: Sassi Maira Soares , Almeida Aislan Pereira de , Coqueiro Raildo Silva , De Brito Júnior Rui Barbosa , Pithon Matheus Melo 
Published: January 2020

Objective: Facial appearance has become an important factor of social interaction. The perception of patients regarding the changes promoted by treatment has become a focus of study today. Thus, the proposal of the present study was to evaluate the esthetic perception of lay people regarding esthetic periodontal changes. Method: The total sample comprised 180 individuals divided into three different age groups (15-19, 35-44, and 65-74 years). Nine images with digital alterations in the gingival contour were used. One of the images served as an esthetic standard for the research (ideal image). The images were presented to the evaluators using slide show software (Microsoft PowerPoint 2013, Microsoft, California). Was used the Wilcoxon, Kruskal-Wallis and Mann-Whitney test. The level of significance was 5% (? = 0.05). Results: Statistical differences were found between the esthetic perception of different age groups. The sample was composed only of lay people of three different age groups, and it was evident that the younger age group has a more accurate perception regarding changes in the gingival contour. Conclusion: The changes in the gingival contour perceived as less attractive were the changes between the central incisors. The younger age group had a more accurate esthetic perception in this study. KEYWORDSPeriodontics; Gingival esthetics; Perception; Esthetics.