bluuebunny/crossref_metadata_2025_split huggingface dataset:
Massive event-shape distributions at N2LL
Authors: Bris Alejandro , Mateu Vicent , Preisser Moritz 
Published: September 2020

Abstract
In a recent paper we have shown how to optimally compute the differential and cumulative cross sections for massive event-shapes at $$ \mathcal{O}\left({\alpha}_s\right) $$
O

α
s

in full QCD. In the present article we complete our study by obtaining resummed expressions for non-recoil-sensitive observables to N2LL + $$ \mathcal{O}\left({\alpha}_s\right) $$
O

α
s

precision. Our results can be used for thrust, heavy jet mass and C-parameter distributions in any massive scheme, and are easily generalized to angularities and other event shapes. We show that the so-called E- and P-schemes coincide in the collinear limit, and compute the missing pieces to achieve this level of accuracy: the P-scheme massive jet function in Soft-Collinear Effective Theory (SCET) and boosted Heavy Quark Effective Theory (bHQET). The resummed expression is subsequently matched into fixed-order QCD to extend its validity towards the tail and far- tail of the distribution. The computation of the jet function cannot be cast as the dis- continuity of a forward-scattering matrix element, and involves phase space integrals in d = 4 − 2ε dimensions. We show how to analytically solve the renormalization group equation for the P-scheme SCET jet function, which is significantly more complicated than its 2-jettiness counterpart, and derive rapidly-convergent expansions in various kinematic regimes. Finally, we perform a numerical study to pin down when mass effects become more relevant.
Hawking-Moss transition with a black hole seed
Authors: Gregory Ruth , Moss Ian G. , Oshita Naritaka , Patrick Sam 
Published: September 2020

Abstract
We extend the concept of Hawking-Moss, or up-tunnelling, transitions in the early universe to include black hole seeds. The black hole greatly enhances the decay amplitude, however, order to have physically consistent results, we need to impose a new condition (automatically satisfied for the original Hawking-Moss instanton) that the cosmological horizon area should not increase during tunnelling. We motivate this conjecture physically in two ways. First, we look at the energetics of the process, using the formalism of extended black hole thermodynamics; secondly, we extend the stochastic inflationary formalism to include primordial black holes. Both of these methods give a physical substantiation of our conjecture.
Shining light on the scotogenic model: interplay of colliders and cosmology
Authors: Baumholzer Sven , Brdar Vedran , Schwaller Pedro , Segner Alexander 
Published: September 2020

Abstract
In the framework of the scotogenic model, which features radiative generation of neutrino masses, we explore light dark matter scenario. Throughout the paper we chiefly focus on keV-scale dark matter which can be produced either via freeze-in through the decays of the new scalars, or from the decays of next-to-lightest fermionic particle in the spectrum, which is produced through freeze-out. The latter mechanism is required to be suppressed as it typically produces a hot dark matter component. Constraints from BBN are also considered and in combination with the former production mechanism they impose the dark matter to be light. For this scenario we consider signatures at High Luminosity LHC and proposed future hadron and lepton colliders, namely FCC-hh and CLIC, focusing on searches with two leptons and missing energy as a final state. While a potential discovery at High Luminosity LHC is in tension with limits from cosmology, the situation greatly improves for future colliders.
Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3
Authors: Wiera Grzegorz , Lebida Katarzyna , Lech Anna Maria , Brzdąk Patrycja , Van Hove Inge , De Groef Lies , Moons Lieve , Petrini Enrica Maria , Barberis Andrea , Mozrzymas Jerzy W. 
Published: September 2020

AbstractLearning and memory are known to depend on synaptic plasticity. Whereas the involvement of plastic changes at excitatory synapses is well established, plasticity mechanisms at inhibitory synapses only start to be discovered. Extracellular proteolysis is known to be a key factor in glutamatergic plasticity but nothing is known about its role at GABAergic synapses. We reveal that pharmacological inhibition of MMP3 activity or genetic knockout of theMmp3gene abolishes induction of postsynaptic iLTP. Moreover, the application of exogenous active MMP3 mimics major iLTP manifestations: increased mIPSCs amplitude, enlargement of synaptic gephyrin clusters, and a decrease in the diffusion coefficient of synaptic GABAAreceptors that favors their entrapment within the synapse. Finally, we found that MMP3 deficient mice show faster spatial learning in Morris water maze and enhanced contextual fear conditioning. We conclude that MMP3 plays a key role in iLTP mechanisms and in the behaviors that presumably in part depend on GABAergic plasticity.
Determination of Mercury Content in Surface Waters Using an Environmentally Non-Toxic Terminating Electrolyte
Authors: Jabłońska Joanna , Kluska Mariusz 
Published: September 2020

AbstractThe paper presents results of the research on the dynamics of changes in the concentration of mercury in surface waters. The importance of mercury as an environmental pollutant results from specific properties of this metal, many sources of contamination, volatility, mobility, stability and high toxicity of its specific chemical forms. Samples of surface water collected from three rivers: the Bug, the Liwiec and the Muchawka were analysed. The Muchawka River flows into the Liwiec River, which in turn is a tributary of the Bug River. The technique of isotachophoresis was employed, using a solution of a biodegradable and environmentally non-toxic derivative of electrostatically stabilised silanates as the terminating electrolyte. The highest average mercury concentration of 0.89 μg/dm3 was determined in water samples collected from the Bug River in January, whereas the lowest concentration of 0.42 μg/dm3 was recorded in water collected from the Muchawka River in September.
Cooling of motor spindles—a review
Authors: Denkena Berend , Bergmann Benjamin , Klemme Heinrich 
Published: September 2020

AbstractThermally induced loads in motor spindles can cause a number of undesired effects. As a result, the process capability of spindles, and thus, the productivity of a process can decrease. Future motor spindles will be exposed to higher mechanical and especially thermal loads due to trends aiming to increase power densities and maximum speeds. These trends are amplified by increasingly powerful drive concepts and developments in bearing technology. Therefore, researchers assume that it will not be possible to raise the performance potential of spindles due to insufficient cooling of its heat sources. A series of different cooling concepts have been researched and developed in recent decades. These developments have been made for different purposes. They also differ considerably in terms of their cooling principles and cooling performance. In this article, these cooling approaches and the motivations for their development are described. Firstly, the causes of heat development in motor spindles are described in a historical context. Subsequently, the effects of heat development on the manufacturing-relevant properties of motor spindles are revealed. Finally, current deficits in the area of spindle cooling and the need for the development and transfer into industrial practice of more efficient and cost-effective cooling concepts to overcome future challenges are discussed.
Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)
Authors: Helmberger Thomas , Golfieri Rita , Pech Maciej , Pfammatter Thomas , Arnold Dirk , Cianni Roberto , Maleux Geert , Munneke Graham , Pellerin Olivier , Peynircioglu Bora , Sangro Bruno , Schaefer Niklaus , de Jong Niels , Bilbao José Ignacio ,   On behalf of the CIRT Steering Committee, Pelage Jean-Pierre , Manas Derek M. , Kolligs Frank T. , Ezziddin Samer , Peters Ralph ,   On behalf of the CIRT Principal Investigators, Albrecht Thomas , D’Archambeau Olivier , Balli Tugsan , Bilgic Sadik , Bloom Alan , Cioni Roberto , Fischbach Roman , Flamen Patrick , Gerard Laurent , Grözinger Gerd , Katoh Marcus , Koehler Michael , Kröger Jan Robert , Kuhl Christiane , Orsi Franco , Ozgun Murat , Reimer Peter , Ronot Maxime , Schmid Axel , Vit Alessandro 
Published: September 2020

Abstract
Purpose
To address the lack of prospective data on the real-life clinical application of trans-arterial radioembolization (TARE) in Europe, the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) initiated the prospective observational study CIRSE Registry for SIR-Spheres® Therapy (CIRT).

Materials and Methods
Patients were enrolled from 1 January 2015 till 31 December 2017. Eligible patients were adult patients treated with TARE with Y90 resin microspheres for primary or metastatic liver tumours. Patients were followed up for 24 months after treatment, whereas data on the clinical context of TARE, overall survival (OS) and safety were collected.

Results
Totally, 1027 patients were analysed. 68.2% of the intention of treatment was palliative. Up to half of the patients received systemic therapy and/or locoregional treatments prior to TARE (53.1%; 38.3%). Median overall survival (OS) was reported per cohort and was 16.5 months (95% confidence interval (CI) 14.2–19.3) for hepatocellular carcinoma, 14.6 months (95% CI 10.9–17.9) for intrahepatic cholangiocarcinoma. For liver metastases, median OS for colorectal cancer was 9.8 months (95% CI 8.3–12.9), 5.6 months for pancreatic cancer (95% CI 4.1–6.6), 10.6 months (95% CI 7.3–14.4) for breast cancer, 14.6 months (95% CI 7.3–21.4) for melanoma and 33.1 months (95% CI 22.1–nr) for neuroendocrine tumours. Statistically significant prognostic factors in terms of OS include the presence of ascites, cirrhosis, extra-hepatic disease, patient performance status (Eastern Cooperative Oncology Group), number of chemotherapy lines prior to TARE and tumour burden. Thirty-day mortality rate was 1.0%. 2.5% experienced adverse events grade 3 or 4 within 30 days after TARE.

Conclusion
In the real-life clinical setting, TARE is largely considered to be a part of a palliative treatment strategy across indications and provides an excellent safety profile.

Level of evidence
Level 3.

Trial registration
ClinicalTrials.gov NCT02305459.
A continuation method for spatially discretized models with nonlocal interactions conserving size and shape of cells and lattices
Authors: Ei Shin-Ichiro , Ishii Hiroshi , Sato Makoto , Tanaka Yoshitaro , Wang Miaoxing , Yasugi Tetsuo 
Published: September 2020

AbstractIn this paper, we introduce a continuation method for the spatially discretized models, while conserving the size and shape of the cells and lattices. This proposed method is realized using the shift operators and nonlocal operators of convolution types. Through this method and using the shift operator, the nonlinear spatially discretized model on the uniform and nonuniform lattices can be systematically converted into a spatially continuous model; this renders both models point-wisely equivalent. Moreover, by the convolution with suitable kernels, we mollify the shift operator and approximate the spatially discretized models using the nonlocal evolution equations, rendering suitable for the application in both experimental and mathematical analyses. We also demonstrate that this approximation is supported by the singular limit analysis, and that the information of the lattice and cells is expressed in the shift and nonlocal operators. The continuous models designed using our method can successfully replicate the patterns corresponding to those of the original spatially discretized models obtained from the numerical simulations. Furthermore, from the observations of the isotropy of the Delta–Notch signaling system in a developing real fly brain, we propose a radially symmetric kernel for averaging the cell shape using our continuation method. We also apply our method for cell division and proliferation to spatially discretized models of the differentiation wave and describe the discrete models on the sphere surface. Finally, we demonstrate an application of our method in the linear stability analysis of the planar cell polarity model.
Last-mile delivery concepts: a survey from an operational research perspective
Authors: Boysen Nils , Fedtke Stefan , Schwerdfeger Stefan 
Published: September 2020

AbstractIn the wake of e-commerce and its successful diffusion in most commercial activities, last-mile distribution causes more and more trouble in urban areas all around the globe. Growing parcel volumes to be delivered toward customer homes increase the number of delivery vans entering the city centers and thus add to congestion, pollution, and negative health impact. Therefore, it is anything but surprising that in recent years many novel delivery concepts on the last mile have been innovated. Among the most prominent are unmanned aerial vehicles (drones) and autonomous delivery robots taking over parcel delivery. This paper surveys established and novel last-mile concepts and puts special emphasis on the decision problems to be solved when setting up and operating each concept. To do so, we systematically record the alternative delivery concepts in a compact notation scheme, discuss the most important decision problems, and survey existing research on operations research methods solving these problems. Furthermore, we elaborate promising future research avenues.
Posterolateral corner of the knee: a systematic literature review of current concepts of arthroscopic reconstruction
Authors: Weiss Sebastian , Krause Matthias , Frosch Karl-Heinz 
Published: September 2020

Abstract
Introduction
Injuries of the posterolateral corner (PLC) of the knee lead to chronic lateral and external rotational instability and are often associated with PCL injuries. Numerous surgical techniques for repair and reconstruction of the PLC are established. Recently, several arthroscopic techniques have been published in order to address different degrees of PLC injuries through reconstruction of one or more functional structures. The purpose of this systematic review is to give an overview about arthroscopic techniques of posterolateral corner reconstructions and to evaluate their safeness.

Materials and methods
A systematic review of the literature on arthroscopic reconstructions of the posterolateral corner of the knee according to the PRISMA guidelines was performed using PubMed MEDLINE and Web of Science Databases on June 15th, 2020. Inclusion criteria were descriptions of surgical techniques to reconstruct different aspects of the posterolateral corner either strictly arthroscopically or minimally-invasive with an arthroscopic assistance.

Results
Arthroscopic techniques differ with regard to the extent of reconstructed units (popliteus tendon, popliteofibular ligament, lateral collateral ligament), surgical approach (transseptal, lateral) and biomechanical results (anatomic vs. non-anatomic reconstruction, restoration of rotational instability and/or lateral instability).

Conclusion
Different approaches to arthroscopic PLC reconstruction are presented, yet clinical results are scarce. Up to now good and excellent clinical results are reported. No major complications are reported in the literature so far.
Role of periostin in ECRS
Authors: Yu Lei , Wang Jisheng , Liu Kai 
Published: September 2020

AbstractPeriostin, an extracelluar matrix protein belonging to the fasciclin family, has been reported to play a key role in the process of Th2-inflammation disease. As eoshinophilic chronic rhinosinusitis has a higher incident rate, studies show that periostin has participated in the process of inflammation and remodeling. This review mainly to summarize researches of periostin in ECRS and to investigate the clinical significance and expression of periostin.
An underutilized orphan tuber crop—Chinese yam : a review
Authors: Epping Janina , Laibach Natalie 
Published: September 2020

Abstract
Main conclusion
The diversification of food crops can improve our diets and address the effects of climate change, and in this context the orphan crop Chinese yam shows significant potential as a functional food.

Abstract
As the effects of climate change become increasingly visible even in temperate regions, there is an urgent need to diversify our crops in order to address hunger and malnutrition. This has led to the re-evaluation of neglected species such as Chinese yam (Dioscorea polystachya Turcz.), which has been cultivated for centuries in East Asia as a food crop and as a widely-used ingredient in traditional Chinese medicine. The tubers are rich in nutrients, but also contain bioactive metabolites such as resistant starches, steroidal sapogenins (like diosgenin), the storage protein dioscorin, and mucilage polysaccharides. These health-promoting products can help to prevent cardiovascular disease, diabetes, and disorders of the gut microbiome.
Whereas most edible yams are tropical species, Chinese yam could be cultivated widely in Europe and other temperate regions to take advantage of its nutritional and bioactive properties. However, this is a laborious process and agronomic knowledge is fragmented. The underground tubers contain most of the starch, but are vulnerable to breaking and thus difficult to harvest. Breeding to improve tuber shape is complex given the dioecious nature of the species, the mostly vegetative reproduction via bulbils, and the presence of more than 100 chromosomes. Protocols have yet to be established for in vitro cultivation and genetic transformation, which limits the scope of research. This article summarizes the sparse research landscape and evaluates the nutritional and medical applications of Chinese yam. By highlighting the potential of Chinese yam tubers, we aim to encourage the adoption of this orphan crop as a novel functional food.
Value of serial echocardiography in diagnosing Kawasaki’s disease
Authors: Hörl Maria , Michel Holger , Döring Stephan , Dechant Markus-Johann , Zeman Florian , Melter Michael , Gerling Stephan 
Published: September 2020

AbstractKawasaki disease (KD) is an acute vasculitis predominantly affecting the small arteries of young children. Up to 25% of untreated patients suffer from coronary artery (CA) complications. Early diagnosis and treatment is mandatory in incomplete KD to reduce the risk of coronary involvement. Between 2002 and 2018, 124 patients have been diagnosed suffering from KD at the University Children’s Hospital Regensburg (KUNO). We assessed luminal diameters of both CAs normalized as Z-scores by 2D-echocardiography. A total of 94 patients were analyzed. Of them, 31 (33%) were affected by an incomplete form of KD. In 24 children (26%), serial echocardiography was necessary in order to confirm diagnosis. Mean Z-scores for the left main coronary artery (LMCA), right main coronary artery (RMCA), and left anterior descending artery increased significantly between the initial (LMCA 0.79z, RMCA 0.15z, LAD 0.49z) and second (LMCA 1.69z, RMCA 0.99z, LAD 1.69z) examination (p < 0.05).Conclusion:To confirm diagnosis of KD, it might not be necessary to detect dilation or aneurysms. Our observation suggests that patients suspected having KD should be monitored with serial echocardiography in order to detect a possible enlargement of the CA diameters, even if Z-scores are within the normal range.

What is Known:• Kawasaki disease (KD) is an acute vasculitis predominantly affecting the small arteries of young children. Up to 25% of untreated patients suffer from coronary artery (CA) complications.• Due to less classic clinical criteria in patients with incomplete KD, the risk for CA pathology is even higher.

What is New:• A significant progression of patients’ CA Z-scores in serial echocardiographic measurements may be helpful to ensure diagnosis of KD early even if Z-scores are within the normal range.• Twenty-seven patients (90%) with incomplete KD could be diagnosed within 10 days of fever, early enough to prevent significantly higher rates of CA aneurysm.
Volumetric spatial behaviour in rats reveals the anisotropic organisation of navigation
Authors: Jedidi-Ayoub Selim , Mishchanchuk Karyna , Liu Anyi , Renaudineau Sophie , Duvelle Éléonore , Grieves Roddy M. 
Published: September 2020

AbstractWe investigated how access to the vertical dimension influences the natural exploratory and foraging behaviour of rats. Using high-accuracy three-dimensional tracking of position in two- and three-dimensional environments, we sought to determine (i) how rats navigated through the environments with respect to gravity, (ii) where rats chose to form their home bases in volumetric space, and (iii) how they navigated to and from these home bases. To evaluate how horizontal biases may affect these behaviours, we compared a 3D maze where animals preferred to move horizontally to a different 3D configuration where all axes were equally energetically costly to traverse. Additionally, we compared home base formation in two-dimensional arenas with and without walls to the three-dimensional climbing mazes. We report that many behaviours exhibited by rats in horizontal spaces naturally extend to fully volumetric ones, such as home base formation and foraging excursions. We also provide further evidence for the strong differentiation of the horizontal and vertical axes: rats showed a horizontal movement bias, they formed home bases mainly in the bottom layers of both mazes and they generally solved the vertical component of return trajectories before and faster than the horizontal component. We explain the bias towards horizontal movements in terms of energy conservation, while the locations of home bases are explained from an information gathering view as a method for correcting self-localisation.
Mortality related to drug-resistant organisms in surgical sepsis-3: an 8-year time trend study using sequential organ failure assessment scores
Authors: Yoshida Junichi , Tamura Tetsuro , Otani Kazuhiro , Inoue Masaaki , Miyatake Eiji , Ishimitsu Toshiyuki , Nakahara Chihiro , Tanaka Masao 
Published: September 2020

AbstractThe difference in sequential organ failure assessment (SOFA) scores from the baseline to sepsis is a known predictor of sepsis-3 outcome, but the prognostic value of drug-resistant organisms for mortality is unexplained. We employed sepsis stewardship and herein report an observational study. Study subjects were patients admitted to the Departments of Surgery/Chest Surgery from 2011 through 2018 with a diagnosis of sepsis and a SOFA score of 2 or more. Our sepsis stewardship methods included antimicrobial and diagnostic stewardship and infection control. We determined the primary endpoint as in-hospital death and the secondary endpoint as the annual trend of the risk-adjusted mortality ratio (RAMR). For mortality, we performed logistic regression analysis based on SOFA score, age, sex, comorbid disease, and the presence of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase inhibitor–producing bacteria. In a total of 457 patients, two factors were significant predictors for fatality, i.e., SOFA score of 9 or more with an odds ratio (OR) 4.921 and 95% confidence interval [95% CI] 1.968–12.302 (P = 0.001) and presence of MRSA with an OR 1.83 and 95% CI 1.003–3.338 (P = 0.049). RAMR showed a decrease during the study years (P < 0.05). Early detection of MRSA may help patients survive surgical sepsis-3. Thus, MRSA-oriented diagnosis may play a role in expediting treatment with anti-MRSA antimicrobials.