bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Physician factors associated with medical errors in Norwegian primary care emergency services. Based on a case – control study with patient complaints as an outset.
Authors: Bratland Svein Zander 
Published: May 2020

Abstract
Background Patient safety incidents are reported as relatively common. To unravel the reasons for these incidents in primary care emergency units (PCEU), patient complaints have been used as an outset. Methods We included the PCEUs in ten major cities and rural parts of Norway, covering one third of the population. In the initial part of our study a case-control design was used to evaluate factors related to complaints. The controls where a random sample of three physicians from the same PCEU and time-period as the physician having evoked a complaint. The inclusion period was 18 months (September 1st 2015 till March 1st 2017). The physician characteristics were: gender, seniority, citizenship at authorization and specialty in general practice. Workload was defined as the magnitude of patient contacts. The physician identities and workload were extracted from the medical records from the fourteen-day period prior to the consultation that elicited the complaint. The other variables were obtained from the Norwegian physician position register. In the present study a total of 77 physicians were included in the complaint group and 217 in the random sample group. The assessments of the medical records were divided in three groups: medical error, inconclusive and no medical error. Associations between these groups, physician characteristics and workload, were tested by chi-square, Fisher’s exact and t-tests separately for the complaint and randomized group. The data were analyzed using SPSS. Results In the complaint group 53.2% of the medical records were assessed as being erroneous. In the random sample group this percentage was 3.2. The proportion inconclusive assessments was similar in both groups (29.9 and 27.6%). In the complaint group the percentages for no-error and inconclusive for the female physicians were 30.8 and 15.4; and for the male physicians 9.8 and 27.3, p=0.027. Conclusions In the complaint group male physicians had the lowest percentage no-error, and the highest percentage of inconclusive medical record for assessing medical errors, compared to their female colleagues. The Norwegian regulations for working in a PCEU may have modulated the impact of the other variables. Future research should focus on the underlying elements for these findings.
Comparison of postoperative changes in radial peripapillary capillary density between femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery using optical coherence tomography angiography
Authors: Zhang Hong , Tan Liangzhang , Tian Fang , Gong Xue , Chen Lu , Ma Zhiqiong , Liang Jingli , Guo Chen , Li Xiaorong 
Published: May 2020

Abstract
Purpose: To assess differences in post-surgical radial peripapillary capillary (RPC) density changes between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) using optical coherence tomography angiography (OCTA).Methods: Fifty-two eyes of 52 patients were enrolled in this study. Depending on their preference, patients with age-related cataract underwent FLACS or CPS. Automated peripapillary maps and capillary density calculations were retrospectively evaluated using OCTA before surgery and on day 1 and months 1 and 3 postoperatively.Results: The whole-image and peripapillary RPC densities were lower at day 1 and months 1 and 3 postoperatively than before surgery in the FLACS group (all P < 0.05). However, there was no change in the whole-image and peripapillary RPC densities before and after surgery, across different time-points, in the CPS group (all P > 0.05). Moreover, comparison of data corresponding to each time-point between the FLACS and CPS groups showed no significant differences in any metrics prior to surgery (all P > 0.05). However, the whole-image and peripapillary RPC densities were significantly different at day 1 and month 1 after the surgery (all P < 0.05). At the 3-month follow-up, we did not observe significant differences (all P > 0.05). Conclusions: Postoperative whole-image and peripapillary RPC densities were lower in the FLACS group than in the CPS across time-points. While the short-term RPC density changes were resolved, to elucidate the long-term implications of FLACS, especially for eyes with glaucoma, diabetic retinopathy, etc., further investigations are required.
Physiological and transcriptomic characterization of a yellow-green leaf mutant of maize
Authors: Li Tingchun , Yang Huaying , Lu Yan , Dong Qing , Liu Guihu , Chen Feng , Zhou Yingbing 
Published: May 2020

Abstract
Background

Chlorophylls, green pigments in chloroplasts, are essential for photosynthesis. Reduction in chlorophyll contents may result in retarded growth, dwarfism, and sterility. In this study, a yellow-green leaf mutant of maize, indicative of abnormity in chlorophyll contents, was identified. The physiological parameters of this mutant were measured. Next, global gene expression of this mutant was determined using transcriptome analysis and compared to that of wild-type maize plants.

Results

The yellow-green leaf mutant of maize was found to contain lower contents of chlorophyll a , chlorophyll b and carotenoid compounds. It contained fewer active PSII centers and displayed lower values of original chlorophyll fluorescence parameters than the wild-type plants. The real-time fluorescence yield, the electron transport rate, and the net photosynthetic rate of the mutant plants showed reduction as well. In contrast, the maximum photochemical quantum yield of PSII of the mutant plants was similar to that of the wild-type plants. Comparative transcriptomic analysis of the mutant plants and wild-type plants led to the identification of differentially expressed1122 genes, of which 536 genes were up-regulated and 586 genes down-regulated in the mutant. Five genes in chlorophyll metabolism pathway, nine genes in the tricarboxylic acid cycle and seven genes related to the conversion of sucrose to starch displayed down-regulated expression. In contrast, genes encoding a photosystem II reaction center PsbP family protein and the PGR5-like protein 1A (PGRL1A) exhibited increased transcript abundance.

Conclusions

The yellow-green leaf mutant of maize contained fewer active PSII centers with lowered net photosynthesis rate, but have the similar value of the maximum photochemical quantum yield of PSII with that of the wild-type plants. Analysis of differentially expressed genes through transcriptome analysis revealed the down-regulated genes which may be responsible for chlorophyll deduction and changes of photosynthetic characteristics. The up-regulated genes would be helpful to maintain the active PSII centers of the yellow-green leaf mutant.
Two user-friendly models and a simple cutoff value of neutrophil to lymphocyte ratio (NLR) for early diagnosis of diabetic nephropathy in middle-elderly aged patients with type 2 diabetes: A cross-sectional study
Authors: Tian Yiming , Li Tao , Gu Hongyuan , Wang Rui , Ma Chunming , Wang Rui 
Published: May 2020

Abstract
Background: Neutrophil to lymphocyte ratio (NLR) has been shown to predict worse outcomes of diabetic nephropathy (DN). This cross-sectional study aimed to investigate the association of NLR and DN in middle-elderly aged patients with type 2 diabetes, and attempt to confirm an optimized cutoff value of NLR for DN prediction. Methods: A total of 146 patients with type 2 diabetes were retrospectively included in this study. DN was defined as urine albumin to creatinine ratio (UACR) ≥30mg/g, or effective glomerular filtration rate (eGFR) ≤ 60ml/min·1.73m2. Logistic regression anlysis, canonical discriminant functions and receiver operating characteristics (ROC) curve analysis were used to construct the discriminant equations and identify the cutoff value of parameters. Results: NLR, diabetes duration, systolic blood pressure (SBP) and lipo-protein A [Lp(a)] independently predicted DN diagnosis after adjusted by multi-variables. NLR value of 2.04 had a sensitivity of 48.9% and a specificity of 80.8% in predicting DN, with area under the curve (AUC) of 0.666. When the threshold of NLR was elevated to 2.50, the specificity and sensitivity were 90.9% and 29.8%, respectively. User-friendly model 1 and model 2 were constructed using the independent risk factors mentioned above, with the AUC of 0.819 and 0.817, respectively. Conclusions: Two models of user-friendly equations were constructed for early prediction of DN, which could be easily calculated and stored in office computer. NLR threshold of 2.50 was recommended in clinical use to locate the patients at high risk of DN, for its high specificity and remarkable convenience.
Long non-coding RNA SNHG6 promotes tumorigenesis of nasopharyngeal carcinoma by competitively binding to miR-944 with RGS17
Authors: Han Yu’e , Liu Xing , Li Guangling , Ju Xia , Song Zhongyi 
Published: May 2020

Abstract
Background

Previous studies have shown that many long noncoding RNAs (lncRNAs) are involved in the pathogenesis of nasopharyngeal carcinoma (NPC). However, the regulatory mechanism of lncRNA SNHG6 remains unknown. Therefore, this study was design to preliminarily elucidate the role of SNHG6 in NPC.
Methods

The mRNA expression was detected by RT-qPCR. CCK-8, Transwell and dual luciferase reporter assays were used to investigate the function of SNHG6 in NPC.
Results

Upregulation of SNHG6 and downregulation of miR-944 were identified in NPC and were associated with TNM stage and distant metastasis in NPC patients. Additionally, SNHG6 acts as a molecular sponge of miR-944. More importantly, SNHG6 promoted NPC cell proliferation, migration and invasion by downregulating miR-944. Further, RGS17 was confirmed to be a direct target of miR-944. MiR-944 restrained NPC progression by targeting RGS17. Besides that, knockdown of RGS17 was found to block NPC progression. Upregulation of SNHG6 weakened the suppressive effect of RGS17 knockdown in NPC.
Conclusion

LncRNA SNHG6 promotes tumorigenesis of NPC by competitively binding to miR-944 with RGS17.
Germinated Brown Rice Protects H9c2 Cardiomyocyte against Simulated Ischemic/Reperfusion Injury via Mediated Mitochondria Function
Authors: Demeekul Kanokwan , Suthammarak Wichit , Petchdee Soontaree 
Published: May 2020

Abstract
Background

Ischemia/reperfusion (I/R) injury is the major mechanism during Ischemic Heart Disease (IHD). The key modulator of I/R injury is dysregulation of mitochondria function. Germinated Brown Rice (GBR) has recommended as a bio-functional food and has clarified the potential properties in several effects. However, the effect of GBR mediated cardioprotective properties, focusing on the role of mitochondrial function, remains unexplored. Thus, this study aims to investigate the cardioprotective effects of GBR pretreatment against simulated I/R injury.
Results

H9c2 cardiomyocytes were incubated with GBR at a concentration of 5 ƞg/ml for 24 hours and/or simulated I/R (sI/R) for 40 minutes. Cell viability and cell apoptosis were assessed by 7-AAD staining and AnnexinV/PI staining, respectively. For evaluation of mitochondrial functions, not only mitochondrial membrane potential was determined by JC-1 staining but also mitochondrial respiration was represented by oxygen consumption rate (OCR) using Seahorse Flux analyzer. The results revealed that administration of GBR prior to sI/R significantly decreased the percentage of cell death and total cell apoptosis in H9c2 during stimulation of ischemic/reperfusion. In addition, pretreatment of cardiomyocytes with GBR remarkably stabilized mitochondrial membrane potential and improved impaired mitochondrial respiration in simulated-H9c2 injury.
Conclusion

the present research is the first study to report the effective cardioprotection of GBR. Pretreatment of GBR potentially protects H9c2 cardiomyocytes against sI/R injury through mitochondrial function. The underlying therapeutic activities are possibly associated with its bio-functional compounds. However, the underlying mechanism on cardioprotective effects of GBR needs further studies.
Endotracheal tube cuff pressure – how fast paramedics can learn the optimal inflation? - comparison of different methods
Authors: Ilczak Tomasz Piotr , Cwiertnia Michal Tomasz , Bialon Piotr , Szlagor Michal , Kudlacik Beata , Rak Małgorzata , Bialka Szymon , Ubych Adam , Stasicki Arkadiusz , Waksmanska Wioletta , Bujok Jan , Mikulska Monika , Bobinski Rafal , Kawecki Marek Stanisław 
Published: May 2020

Abstract
Background

Tracheal intubation is the optimal method for opening up the airways. Performed correctly, it prevents stomach contents from entering the respiratory tract, and allows asynchronous CPR to be conducted during sudden cardiac arrest. An important element of correct intubation is proper inflation of the endotracheal tube cuff. Research has shown that when medical personnel use the palpation technique, the cuff is usually inflated incorrectly. This can result in numerous health complications for the patient.
Methods

This research was conducted in 2020 on a group of paramedics participating in the 15th International Winter Championship of Medical Rescuers in Bielsko-Biała. The aim of the research was to assess two methods of inflating the endotracheal tube cuff. Method A involved inflating the cuff using a syringe and assessing the pressure in the control cuff using the palpation technique. Method B involved inflating the cuff using a manometer. During the inflation, both the cuff inflation pressure and the time required to complete the procedure were recorded. Analysis was also conducted on whether completion of certified ALS and ACLS training had any influence on the effectiveness of the inflation procedure.
Results

The research showed that paramedics using method B significantly more often inflated the endotracheal tube cuff to the correct pressure than those using method A. However, when method B was used, the procedure took longer to conduct. The study also showed that completion of certified ALS or ACLS training did not have a significant influence on proper inflation of the cuff. Those who had completed certified training courses took significantly longer to inflate the endotracheal tube cuff when using method A.
Conclusions

Inflation of the endotracheal tube cuff by use of a syringe, followed by the palpation technique for assessing the inflation of the cuff balloon is ineffective. Paramedic teams should be equipped with manometers to be used for inflating the endotracheal tube cuff.
Treatment Failure with combined csDMARDs increases the risk of Low Muscle Mass in women with Rheumatoid Arthritis: a cross-sectional study
Authors: Ramirez-Villafaña Melissa , Rodriguez-Jimenez N Alejandra , Gamez-Nava Jorge I , Aceves-Aceves Javier A , Saldaña-Cruz Ana M , Cardona-Muñoz Ernesto G. , Totsuka-Sutto Sylvia E , Ponce-Guarneros J Manuel , Cons-Molina Fidencio , Trujillo Xochitl , Huerta Miguel , Cruz-Jentoft Alfonso J , Gonzalez-Lopez Laura 
Published: May 2020

Abstract
Background Low muscle mass (myopenia) is frequent in rheumatoid arthritis (RA) patients with a long-disease duration. Although, the use of combined therapy with conventional synthetic DMARDs (csDMARDs) is one of the main strategies observed in these patients; there is a lack of information if the failure to these therapies increases the risk of myopenia. Objective: To evaluate whether the treatment failure to combined therapy with conventional synthetic DMARDs is an independent risk factor for low skeletal muscle mass in women with RA. Methods This cross-sectional study compared 277 women with RA (cases) and 237 women from non-rheumatic population (controls). In RA patients, we assessed clinical, epidemiological, and therapeutic variables (identifying treatment failure to combined therapy with csDMARDs. The skeletal muscle index (SMI) was estimated by DXA. Low skeletal muscle mass was defined as SMI<5.45 kg/m2. Multivariate logistic regression analyses were used to a) evaluate whether RA is an independent risk factor of myopenia in comparison with non-rheumatic population and b) identify if treatment failure with csDMARDs is an independent risk factor of myopenia in RA. Results RA patients had a higher prevalence of low skeletal muscle mass than controls (27.8% vs. 15.6%, p=0.001). After adjusting for other factors, RA patients had higher risk of low skeletal muscle mass than controls (OR: 2.7, 95%CI:1.7 to 4.5). Risk factors of low muscle mass in RA patients; were: menopause (OR: 2.3, 95%CI: 1.2 to 4.6, p=0.02) and a failure to combined therapy with csDMARDs (OR: 2.4, 95%CI: 1.10 to 5.81, p=0.03). Conclusions Rheumatoid arthritis is associated with an increased risk of myopenia. Treatment Failure with conventional-synthetic DMARDs constitutes a strong risk factor for deteriorated skeletal muscle mass.
Quality of Work Life and Associated Factors among Nurses Working in Wollega Zones Governmental Hospitals, West Ethiopia, 2018
Authors: Mosisa Getu , Abadiga Muktar , Oluma Adugna , Wakuma Bizuneh 
Published: May 2020

Abstract
Background Quality of work-life refers to the extent to which members of a work organization can satisfy their personal needs through their work experience in the organization. High quality of working life is critical for healthcare organizations to attract and retain qualified, committed and motivated employees and also lead to high task performance. However, there are few studies regarding quality of work life among nurses in Ethiopia. The objective of this study was to assess quality of work life and associated factors among nurses working in Wollega Zones governmental hospitals, 2018.Methods Institutional based cross - sectional study design was conducted on 212 nurses working in wollega zones governmental hospitals from November to December, 2018. The study participants were selected by using simple random sampling techniques. The data was entered into Epi data version 3.1 and then exported into Statistical Package for the Social Sciences window version 20.0 for analysis. Multiple regression analysis was conducted to identify factors associated with quality of working life of nurses. Statistical significance was declared at p<0.05.Result A total of 212 nurses were involved in the study. The study revealed that about 108(50.5% of nurses have good quality of work life. Income and dependent family were significantly associated with quality of work life. In this study, Nurses who have no dependent family were 2.72 (AOR 2.72, 95% CI: 1.38, 5.38) times more likely to have good quality of work life compared to those who have dependent family. Nurses whose monthly income 446-5294 were 2.39(AOR 2.39 95% CI: 1.08, 5.37) times more likely to have good quality of work life compared to those who got less than 3653.Conclusion Nearly half of nurses were dissatisfied with the quality of their work life . The study revealed that monthly income and presence of dependent family showed significant association with quality of work life. Bringing up and maintaining a higher level of quality of work life among nurses is a key to promote job satisfaction and enhance quality of patient care.
Factors associated with patient satisfaction with perioperative anesthesia care at Hawassa university comprehensive specialized hospital, Ethiopia: Cross-sectional study design
Authors: Siraneh Amanu Gashaw , Welda Getahun Dendir , Chanko Kebreab Paulos 
Published: May 2020

Abstract
Background

Patient satisfaction in relation to perioperative anesthesia care represents an essential aspect of quality health care management. The assessment of patient satisfaction is a reality of practice today for good patient satisfaction with health care provider interaction and health influencing factors.
Objectives

To assess the magnitude and associated factor of patient satisfaction towards anesthesia care at Hawassa University comprehensive specialized Hospital April 5, – May 5, 2019Gc.
Method:

A prospective cross-sectional study design was employed in an adult surgical patient scheduled for surgery under general anesthesia and the regional anesthesia level of satisfaction and factor associated with satisfaction was analyzed. Data was entered info version 7 and transfer to SPSS version 25 .0 for analysis. Normality test checked by using Shapiro-Wilk and Kolmogorov-Smirnov the data was normally distributed. Then the frequency, percentage, and cross-tabulation with different variables were determined, lastly, the magnitude and associated factor analyzed by binary logistic regression a multivariate logistic regression. Variables P-value < 0.2 binary logistic regression included in a multivariate logistic regression and p_value less than 0.05 was Taken as statistically significant.
Result

A Total of 200patient included in this study with a response rate of 100%. The main finding of this study was predictors of perioperative patient dissatisfaction were general anesthesia, duration of surgery, nausea, and vomiting, and pain after surgery. The magnitude of patient satisfaction is 60%. Odds of the patient who took general anesthesia were 2.31(1.096, 4.142) p = 0.026 more dissatisfied than regional anesthesia. Odds of the patient duration of surgery 2-3hr 0.313(0.124, 0.792) less likely dissatisfied than the duration of surgery 1hr.The odds of patient nausea and vomiting AOR = 2.575(1.163, 5.698) P = 002 more likely dissatisfied than didn’t have nausea and vomiting. The odds of patient pain after surgery AOR = 2.28(1.084, 4.76) more likely dissatisfied than the patient didn’t have pain after surgery.
Conclusion

patient satisfaction with perioperative anesthesia care Compared to another study magnitude of satisfaction very low, regular study and intervention should do every time /year in order to increase patient satisfaction.
Quantum Gene Chain Coding Bidirectional Neural Network for Residual Useful Life Prediction of Rotating Machinery
Authors: Li Feng , Cheng Yang-Yang , Tang Bao-Ping , Zhou Xue-Ming , Xiong Rui-Ping 
Published: May 2020

Abstract
In classical recurrent neural networks, the pre- and post-relationships of time series tend to be neglected so that long-term overall memory is generally inaccessible; meanwhile, the weights are transferred and updated mainly by the gradient descent method, which leads to their low prediction accuracy and high computation cost in the application of residual useful life (RUL) prediction of rotating machinery (RM). In view of this, a quantum gene chain coding bidirectional neural network (QGCCBNN) is proposed to predict RUL of RM in this paper. In our proposed QGCCBNN, the quantum bidirectional transmission mechanism is designed to establish the pre- and post-relationships of time series for readjusting the weight parameters according to the feedback from the output layer, so that higher consistency between the input information and the overall memory of the network can be realized, thus endowing QGCCBNN with better nonlinear approximation ability. Moreover, in order to improve the global optimization ability and convergence speed, the quantum gene chain coding instead of gradient descent method is constructed to transmit and update data, in which the qubit probability amplitude real number coding is adopted and the cosine and sinusoidal qubit probability amplitudes corresponding to the minimum loss function are compared with those of the current time by the phase selection matrix for the directional parallel updating of the weight parameters. On this basis, a new RUL prediction method for RM is proposed, and higher prediction accuracy as well as desirable efficiency can be obtained due to the advantages of QGCCBNN in nonlinear approximation ability and convergence speed. The experimental example for RUL prediction of a double-row roller bearing demonstrates the effectiveness of our proposed method.