bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of axillary ultrasound and standard breast MRI for differentiation between limited and advanced axillary nodal disease in clinically node-positive breast cancer patients
Authors: Samiei S. , van Nijnatten T. J. A. , van Beek H. C. , Polak M. P. J. , Maaskant-Braat A. J. G. , Heuts E. M. , van Kuijk S. M. J. , Schipper R. J. , Lobbes M. B. I. , Smidt M. L. 
Published: November 2019

AbstractPreoperative differentiation between limited (pN1; 1–3 axillary metastases) and advanced (pN2–3; ≥4 axillary metastases) nodal disease can provide relevant information regarding surgical planning and guiding adjuvant radiation therapy. The aim was to evaluate the diagnostic performance of preoperative axillary ultrasound (US) and breast MRI for differentiation between pN1 and pN2–3 in clinically node-positive breast cancer. A total of 49 patients were included with axillary metastasis confirmed by US-guided tissue sampling. All had undergone breast MRI between 2008–2014 and subsequent axillary lymph node dissection. Unenhanced T2-weighted MRI exams were reviewed by two radiologists independently. Each lymph node on the MRI exams was scored using a confidence scale (0–4) and compared with histopathology. Diagnostic performance parameters were calculated for differentiation between pN1 and pN2–3. Interobserver agreement was determined using Cohen’s kappa coefficient. At final histopathology, 67.3% (33/49) and 32.7% (16/49) of patients were pN1 and pN2–3, respectively. Breast MRI was comparable to US in terms of accuracy (MRI reader 1 vs US, 71.4% vs 69.4%, p = 0.99; MRI reader 2 vs US, 73.5% vs 69.4%, p = 0.77). In the case of 1–3 suspicious lymph nodes, pN2–3 was observed in 30.4% on US (positive predictive value (PPV) 69.6%) and in 22.2–24.3% on MRI (PPV 75.7–77.8%). In the case of ≥4 suspicious lymph nodes, pN1 was observed in 33.3% on US (negative predictive value (NPV) 66.7%) and in 38.5–41.7% on MRI (NPV 58.3–61.5%). Interobserver agreement was considered good (k = 0.73). In clinically node-positive patients, the diagnostic performance of axillary US and breast MRI is comparable and limited for accurate differentiation between pN1 and pN2–3. Therefore, there seems no added clinical value of preoperative breast MRI regarding nodal staging in patients with positive axillary US.
MiR-27b-3p promotes migration and invasion in colorectal cancer cells by targeting HOXA10
Authors: Yang Xiangling , Chen Junxiong , Liao Yao , Huang Lanlan , Wen Chuangyu , Lin Mengmeng , Li Weiqian , Zhu Yonglin , Wu Xiaojian , Iwamoto Aikichi , Wang Zhongyang , Liu Huanliang 
Published: November 2019

Abstract
Purpose: Dysregulation of microRNAs (miRNAs) contributes to tumor progression via the regulation of the expression of specific oncogenes and tumor suppressor genes. One such example, miR-27b-3p, has reportedly been involved in tumor progression in many types of cancer. The aim of the present study was to delve into the role and the underlying mechanism of miR-27b-3p in colorectal cancer (CRC) cells. Methods: In the present study, we detected the expression level of miR-27b-3p by RT-PCR. The effect of miR-27b-3p overexpression on cell proliferation in CRC cells was evaluated by cell counting and Edu assays. Transwell migration and invasion assays were used to examine the effects of cell migration and invasion. Bioinformatics, luciferase reporter assay and western blot assay were performed to identify the target of miR-27b-3p. Results: Here, we have demonstrated that although miR-27b-3p can affect cell morphology, it has no observable effect on the proliferation of CRC cells. However, it significantly promotes the migration and invasion of CRC cells. We discovered that HOXA10 was a newly identified target of miR-27b-3p in CRC cells, as confirmed by bioinformatics, western blots and dual luciferase reporter assay. Furthermore, the overexpression of miR-27b-3p or the suppression of HOXA10 can activate the integrin β1 signaling pathway. In conclusion, our results reveal a new function of miR-27b-3p that demonstrates its ability to promote CRC cell migration and invasion by targeting the HOXA10/integrin β1 cell signal axis. Conclusion: This may provide a mechanism to explain why miR-27b-3p promotes CRC cell migration and invasion.
Informationsfluss und Prozessgestaltung im Team verbessern
Authors: Widdel Franziska , Schneider Wencke 
Published: November 2019

ZusammenfassungDamit im hektischen Arbeitsalltag keine wichtigen Informationen mehr verloren gehen, stellen wir Ihnen das Teaming Board vor. Es ist ein lösungsorientiertes Führungsinstrument, mit dem sich die Informationsweitergabe und Prozessgestaltung in der Patientenversorgung verbessern lassen. Dabei bringt es Leitungen und Mitarbeitende aller Qualifikationsstufen zusammen und hält Beratungsergebnisse tagesaktuell und strukturiert fest.
Molecular breeding approaches for production of disease-resilient commercially important tobacco
Authors: Kakar Kaleem U , Nawaz Zarqa , Cui Zhouqi , Ahemd Nazeer , Ren Xueliang 
Published: November 2019

AbstractTobacco is one of the most widely cultivated nonfood cash crops, a source of income, model organism for plant molecular research, a natural pesticide and of pharmaceutical importance. First domesticated in South Americas, the modern-day tobacco (Nicotiana tabacum) is now cultivated in more than 125 countries to generate revenues worth billions of dollars each year. However, the production of this crop is highly threatened by the global presence of devastating infectious agents, which cause huge fiscal loss. These threats have been battled through breeding for acquiring disease resilience in tobacco plants, first, via conventional and now with the use of modern molecular breeding approaches. For efficacy and precision, the characterization of the genetic components underlying disease resistance is the key tool in tobacco for resistance breeding programs. The past few decades have witnessed significant progress in resilience breeding through advanced molecular techniques. The current review discusses history of tobacco breeding since its time of origin till date, highlighting the most widely used techniques and recent advances in molecular research and strategies for resistance breeding. In addition, we narrate the budding possibilities for the future. This review will provide a comprehensive and valuable information for the tobacco growers and researchers to deal with the destructive infectious diseases.
Annotated Draft Genomes of Two Caddisfly Species Plectrocnemia conspersa CURTIS and Hydropsyche tenuis NAVAS (Insecta: Trichoptera)
Authors: Heckenhauer Jacqueline , Frandsen Paul B , Gupta Deepak K , Paule Juraj , Prost Stefan , Schell Tilman , Schneider Julio V , Stewart Russell J , Pauls Steffen U 
Published: November 2019

Abstract
Members of the speciose insect order Trichoptera (caddisflies) provide important ecosystem services, for example, nutrient cycling through breaking down of organic matter. They are also of industrial interest due to their larval silk secretions. These form the basis for their diverse case-making behavior that allows them to exploit a wide range of ecological niches. Only five genomes of this order have been published thus far, with variable qualities regarding contiguity and completeness. A low-cost sequencing strategy, that is, using a single Oxford Nanopore flow cell per individual along with Illumina sequence reads was successfully used to generate high-quality genomes of two Trichoptera species, Plectrocnemia conspersa and Hydropsyche tenuis. Of the de novo assembly methods compared, assembly of low coverage Nanopore reads (∼18×) and subsequent polishing with long reads followed by Illumina short reads (∼80–170× coverage) yielded the highest genome quality both in terms of contiguity and BUSCO completeness. The presented genomes are the shortest to date and extend our knowledge of genome size across caddisfly families. The genomic region that encodes for light (L)-chain fibroin, a protein component of larval caddisfly silk was identified and compared with existing L-fibroin gene clusters. The new genomic resources presented in this paper are among the highest quality Trichoptera genomes and will increase the knowledge of this important insect order by serving as the basis for phylogenomic and comparative genomic studies.
“It’s My Time”: Older Adults’ Experiences and Perceived Benefits of Participation in an Intergenerational Rock Band
Authors: Wlodarczyk Natalie 
Published: November 2019

Abstract
The purpose of this qualitative content analysis was to explore the experiences and perceived benefits for older adult members who participated in an intergenerational rock band (IGRB) pairing older adults with college students. Participants (n = 29) were first-time older adult IGRB members who completed semi-structured interviews over the course of 5 years. Interviews were completed within 1 week of the conclusion of the semester-long participation in the IGRB. Each interview was digitally recorded, manually transcribed, and analyzed using an iterative approach to thematic analysis. Experiences and perceived benefits associated with participation in the IGRB for these older adults were encompassed by four themes: Staying Active, Wanting to Try Something New, Feeling Connected, and Seeking Positive Experiences. Findings indicate that an IGRB is an innovative, collaborative, and inclusive intergenerational music-making experience that leaves a multifaceted and overall positive impact on its older adult members. Themes suggest that older adults with musical backgrounds may enjoy an experience like an IGRB because it brings a level of familiarity coupled with the opportunity to try something new and different from their previous experiences with music. A key contribution of this study is the importance of promoting a judgment-free environment for singing that is inclusive of all ability levels. Developing a better understanding of older adults’ motivations for participating in an IGRB may help us to plan future music experiences for older adults and broaden our reach to the older adult community.
Safety and efficacy of supplements in pregnancy
Authors: Brown Benjamin , Wright Ciara 
Published: November 2019

AbstractPregnancy is a time where expectant mothers often focus on their diet to improve their own health and to preserve the future health of their children. There is much conflicting information in the public domain about the safety and/or efficacy of nutritional supplements during pregnancy. Despite this, the market for supplements is growing. This review discusses the roles of critical nutrients in pregnancy and the available evidence on the use of supplements to reduce risks and improve maternal and fetal outcomes. Recommendations are made for pregnant women, taking into account safety data and tolerable upper intakes set for pregnant women. It is important for dieticians, nutritionists, physicians, and other healthcare providers to be able to offer accurate and evidence-based advice on supplement use in pregnancy. Routine supplementation may not be necessary for all, but individuals at risk are identified.
Interprofessional Provider Attitudes Toward the Initiation of Epidural Analgesia in the Laboring Patient: Are We All on the Same Page?
Authors: Lipps J. , Lawrence A. , Palettas M. , Small R.H. , Soma L. , Coffman J.C. 
Published: November 2019

(Int J Obstet Anesth. 2019;37:57–67)
During labor and delivery, the initiation of labor epidural analgesia should ultimately be determined by the patient’s preference. Practice guidelines from both the American Society of Anesthesiologists and the American College of Obstetricians and Gynecologists state that epidural analgesia can be offered early in labor and maternal request should be a legitimate indication for performing the procedure. However, different healthcare providers may prioritize different factors when counseling patients on the subject of the “best” time during labor to request epidural analgesia. In fact, information is limited about the attitudes of different types of health care providers regarding the timing of epidural placement during labor. This study surveyed a variety of providers to determine how patient factors or circumstances might affect their decision-making about the timing of epidural labor analgesia initiation. Their goal was to use this survey data to identify differences among provider types and ultimately improve understanding and education on the topic to promote patient-centered care.
Population-based Cohort Study of Hospital Delivery Volume, Geographic Accessibility, and Obstetric Outcomes
Authors: Aubrey-Bassler F.K. , Cullen R.M. , Simms A. , Asghari S. , Crane J. , Wang P.P. , Godwin M. 
Published: November 2019

(Int J Gynecol Obstet. 2019;146:95–102)
There is no consensus on the ideal distribution of maternal health care between rural and urban areas. Studies on this topic have been mixed, sometimes showing poorer outcomes for women in rural areas and for those who travel further to obstetric services. Studies have also suggested women delivering at higher-volume hospitals experienced improved outcomes. These studies, however, may not consider women who travel farther distances to high-volume hospitals. In Canada, high-risk women are often referred to high-volume and high-level medical centers, which confounds the relationship among delivery volume, geographic accessibility and obstetric outcomes. This study aimed to quantify the effect of geographic accessibility and delivery volume on outcomes for both mother and child, in an effort to inform policy decisions.
A Systematic Review of the Cost-effectiveness of Uterotonic Agents for the Prevention of Postpartum Hemorrhage
Authors: Lawri T.A. , Rogozińska E. , Sobiesuo P. , Vogel J.P. , Ternent L. , Oladapo T. 
Published: November 2019

(Int J Gynecol Obstet. 2019;146:56–64)
Around 5% of women giving birth worldwide experience postpartum hemorrhage (PPH). PPH is defined as blood loss of ≥500 mL within a day of birth and most often occurs when the uterus does not contract following delivery. All women giving birth should be offered a uterotonic agent in the third stage of labor, according to World Health Organization (WHO) guidelines. Uterotonic agents for PPH prevention include oxytocin, ergometrine, misoprostol, carbetocin, injectable prostaglandins and syntometrine (a combination of ergometrine and oxytocin). WHO recommends oxytocin as a first-choice uterotonic for the prevention of PPH. Previous single-setting studies have assessed single uterotonics for cost-effectiveness. This review aimed to assess the cost-effectiveness of all available options of uterotonic agents for the prevention of PPH.
Consultation, Surveillance, Monitoring, and Intensive Care (COSMIC): A Novel 4-Tier Program to Identify and Monitor High-Risk Obstetric Patients From the Clinic to Critical Care
Authors: Lockhart E.M. , Hincker A. , Klumpner T.T. , Hofer J. , Cahill A.G. , Palanisamy A. , Boyle W. , Ginosar Y. 
Published: November 2019

(Anesth Analg. 2019;128(6):1354–1360)
The majority of obstetric patients experience good outcomes from the birthing process. However, a small group of women develop serious morbidity or even die during pregnancy, labor, or delivery. This article described the consultation, surveillance, monitoring, and intensive care (COSMIC) program that has been implemented in the authors’ institution to escalate serious obstetric patient issues to the appropriate level of medical care. The goal of the COSMIC program is to optimize available resources for high-risk obstetrical patients in the most cost effective and efficient manner.
Plasma and Cerebrospinal Fluid Inflammatory Cytokines in Perinatal Depression
Authors: Miller E.S. , Sakowicz A. , Roy A. , Yang A. , Sullivan J.T. , Grobman W.A. , Wisner K.L. 
Published: November 2019

(Am J Obstet Gynecol. 2019;220:271.e1–271.e10)
Perinatal depression affects 1 in 7 women, and there is a clear need for more effective and accessible interventions. Depression outside of pregnancy has been increasingly considered a disorder of immune hyperactivation, yet there is not a clear understanding of the mechanisms of perinatal depression. Although peripheral inflammatory cytokines have been associated with depression, cytokines are large molecules that cannot freely cross the blood-brain barrier. Inflammation in the cerebrospinal fluid may provide greater insights into alterations in brain function. This study aimed to investigate the association between perinatal depression and inflammatory cytokines in plasma and in cerebrospinal fluid, hypothesizing that higher concentrations of inflammatory cytokines would appear in women with perinatal depression, compared with women without perinatal depression.
Planned Delivery Route of Preterm Breech Singletons, and Neonatal and 2-Year Outcomes: A Population-based Cohort Study
Authors: Lorthe E. , Sentilhes L. , Quere M. , Lebeaux C. , Winer N. , Torchin H. , Goffinet F. , Delorme P. , Kayem G. 
Published: November 2019

(BJOG. 2019;126(1):73–82)
Choosing the mode of delivery for preterm breech infants can be challenging for clinicians, as there is a lack of evidence-based literature on the subject. Some previous studies have evaluated actual delivery route rather than planned route, or only considered short-term outcomes. This study aimed to determine whether planned delivery route was associated with perinatal and 2-year outcomes in breech preterm infants. The authors hypothesized planned cesarean delivery (PCD) would be associated with improved outcomes.
Granisetron Reduces the Need for Uterotonics but not Sympathomimetics During Cesarean Delivery
Authors: Raimann F.J. , Baldauf H.P. , Louwen F. , Jennewein L. , Fischer D. , Zacharowski K. , Weber C.F. 
Published: November 2019

(Int J Gynecol Obstet. 2019;145:361–366)
Although spinal anesthesia (SPA) for cesarean delivery might improve outcomes for mother and child, it does carry the frequent side effects of hypotension and bradycardia, which in turn can lead to reduced uteroplacental perfusion. There are a few possible causes of hypotension during SPA and several strategies for its treatment. One possible option for preventing hypotension is the use of 5-HT3 receptor antagonists. Previous studies have found that ondansetron, a 5-HT3 receptor, had a positive effect on hemodynamic stability in obstetric studies. There is a lack of evidence for the use of 5-HT3 receptor antagonists to preemptively attenuate the adverse effects of SPA, however. This study aimed to evaluate a 5-HT3 receptor antagonist, granisetron, for its effects on the need for uterotonic agents and sympathomimetics after SPA.
Parkinson's Drug Doesn't Increase Prostate Cancer Risk
Authors: Aschenbrenner Diane S. 
Published: November 2019

The Food and Drug Administration (FDA) has determined that entacapone, used in the management of Parkinson's disease, does not increase the risk of prostate cancer or death from prostate cancer.The decision was based on an analysis of data from a postmarketing clinical trial conducted by the drug manufacturer and an FDA review of data from the Department of Veterans Affairs.
Conditioned Pain Modulation in Chronic Low Back Pain
Authors: Neelapala Y. V. Raghava , Bhagat Madhura , Frey-Law Laura 
Published: November 2019

Objective:
The objective of the review is to determine whether conditioned pain modulation (CPM) is impaired in adults with chronic low back pain (CLBP) when compared with pain-free individuals.

Methods:
A a systematic search of the literature was undertaken using the databases: MEDLINE, Scopus, CINAHL and Web of Science. The citations of included studies were reviewed for additional studies. Observational, cross-sectional, case-control studies published in English between January 1990 and August 2019 were considered. Studies that investigated the efficiency of standardized CPM regimens among defined cases of CLBP and in comparison, with pain-free controls were included. After initial title and abstract screening, 2 authors reviewed the full texts of the eligible articles independently. Risk of bias was carried out using assessment of 4 categories: blinding of the outcome assessors, representativeness of cases to the specified population, comparability of cases and controls, and control of confounding variables.

Results:
In total, 643 records were identified, of which 7 studies were included. Overall, the results of the studies reported mixed conclusions on the efficiency of CPM in CLBP. Three studies identified significant differences for CPM between CLBP and pain-free controls and the other 4 studies reported no significant differences. The common methodological limitations were unclear reporting about blinding of the outcome assessors and inadequate control of confounding factors.

Conclusions:
High-quality research is strongly recommended to determine the function of endogenous pain modulatory mechanisms in CLBP.
Anticoagulation Management and Antithrombin Supplementation Practice during Veno-venous Extracorporeal Membrane Oxygenation
Authors: Protti Alessandro , Iapichino Giacomo E. , Di Nardo Matteo , Panigada Mauro , Gattinoni Luciano 
Published: November 2019

Abstract

Background
There is a lack of consensus on how to manage anticoagulation during veno-venous extracorporeal membrane oxygenation, including antithrombin monitoring and supplementation. The authors’ aim was to determine current practice in a large number of extracorporeal membrane oxygenation centers around the world.

Methods
This was an electronic survey disseminated in 2018 to directors and coordinators of extracorporeal membrane oxygenation centers as well as to extracorporeal membrane oxygenation experts. Participating centers were classified according to some covariates that may affect practice, including 2017 gross national income per capita, primary patient population, and annual extracorporeal membrane oxygenation patient volume.

Results
The authors analyzed 273 unique responses from 50 countries. Systemic anticoagulation was routinely prescribed in 264 (96.7%) centers, with unfractionated heparin being the drug of choice in 255 (96.6%) of them. The preferred method to monitor anticoagulation was activated partial thromboplastin time in 114 (41.8%) centers, activated clotting time in 82 (30.0%) centers, and anti-factor Xa activity in 62 (22.7%) centers. Circulating antithrombin activity was routinely monitored in 133 (48.7%) centers. Antithrombin supplementation was routinely prescribed in 104 (38.1%) centers. At multivariable analyzes, routine antithrombin supplementation was associated with national income, being less likely in lower- than in higher-income countries (odds ratio, 0.099 [95% CI, 0.022 to 0.45]; P = 0.003); with primary patient population being more frequent in mixed (odds ratio, 2.73 [1.23 to 6.0]; P = 0.013) and pediatric-only centers (odds ratio, 6.3 [2.98 to 13.2]; P < 0.001) than in adult-only centers; but not with annual volume of extracorporeal membrane oxygenation cases, being similarly common in smaller and larger centers (odds ratio, 1.00 [0.48 to 2.08]; P = 0.997).

Conclusions
There is large practice variation among institutions regarding anticoagulation management and antithrombin supplementation during veno-venous extracorporeal membrane oxygenation. The paucity of prospective studies and differences across institutions based on national income and primary patient population may contribute to these findings.

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