bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Efficient Data Collection Path Planning Scheme in Wireless Sensor Networks with Mobile Sink
Authors: Chang Jau-Yang , Jeng Jin-Tsong , Sheu Yung-Hoh , Jian Z-Jie , Chang Wei-Yeh 
Published: June 2020

Abstract
Wireless sensor networks with mobile sink provide a mobile device to move into the sensing area for collecting the sensing data. It increases the flexibility and convenience of data gathering in such systems. Taking into account the energy consumption of mobile sink, the moving distance of mobile sink must be reduced efficiently. Hence, it is important and necessary to develop an efficient path planning scheme for the mobile sink in large-scale wireless sensor networks systems. According to the greedy-based algorithms, we adopt an angle bisector concept to create the moving path for the mobile sink. In this paper, a novel efficient data collection path planning scheme with an inner center approach is proposed to reduce the moving distance and to prolong the lifetime of mobile sink in wireless sensor networks. The relationship among moving path, moving distance, and number of sensor nodes are analyzed and discussed. Considering the communication range limitation of sensor nodes and the sensing area with obstacles, the proposed scheme makes an adaptive decision for creating the moving path of mobile sink. Simulation results demonstrate that the reasonable moving path planning can be achieved and the moving distance can be reduced for a mobile sink in wireless sensor networks.
MRI Study on Tibial Nerve of the Ankle Canal and Its Branches: A method of multiplanar reconstruction with three-dimensional dual-excitation balanced steady-state free precession sequence
Authors: Zhang Yan , He Xucheng , Li Juan , Ye Ju , Han Wenjuan , Zhou Shanshan , Zhu Jianzhong , Wang Guisheng , Chen Xiaoxia 
Published: June 2020

Abstract
Background: The display of tibial nerve and its branches in the ankle canal is helpful for the diagnosis of local lesions and compression, and also for clinical observation and surgical planning.The aim of this study was to investigate the feasibility of three-dimensional dual-excitation balanced steady-state free precession sequence (3D-FIESTA-C) multiplanar reconstruction (MPR) display of tibial nerve and its branches of the ankle canal.The subjects were 20 healthy volunteers (40 ankles), aged 22-50, with no history of ankle joint desease. 3D-FIESTA-Csequence was used in the 3.0t magnetic resonance equipment for imaging. During the scanning, each foot was at a 90-degree angle to the tibia so that the results of measurement are more accurate .The tibial nerve of the ankle canal and its branches were displayed and measured at the same level through multiplanar reconstruction.Results: Most of the tibial nerve bifurcation points were located in the ankle canal (57.5%), few (42.5%) were located at the proximal end of the ankle canal, and none was found away from the distal end. The bifurcation between the medial plantar nerve and the lateral plantar nerve is on the line between the tip of the medial malleolus and the calcaneus, and it’s angle is between 6° and 35°.The average cross-sectional diameter of the medial plantar nerve is about mm, and the lateral plantar nerve about mm. In MPR images, the display rates of both the medial calcaneal nerve and the subcalcaneal nerve were 100%, and the starting point of the subcalcaneal nerve was always at the distal end of the starting point of the medial calcaneal nerve. In 55% of cases, there were more than 2 medial calcaneal nerve innervations.Conclusion: The 3D-FIESTA-C MPR can display the morphological features and positions of tibial nerve and its branches. By measuring the distance between each bifurcation point, the tip of the medial malleolus and the angle between this line and the horizontal line that passes the tip of the medial malleolus, the bifurcation point’s projection position on the body surface can be accurately marked. This method not only benefited the imaging diagnosis of tibial nerve and branch-related lesions of the ankle canal, but also provided a good imaging basis to plan the clinical operation of the ankle canal and avoid surgical injury.
Numerical Modeling of Rehabilitation Exercise when Distal Radius Fracture Treated by Splint
Authors: Hua Zhen , Liu Mingming , Wu Mao , Xie Bin , Zhang Yufeng , Wang Jianwei 
Published: June 2020

Abstract
Background

Rehabilitation exercise plays a key role in bone fracture healing. Although traditional clinical experiments and observations are adopted to evaluate the effect of rehabilitation exercise, the biomechanical mechanism is still unclear. There are few reports on the mechanical analysis model of elbow flexion rehabilitation exercise of the complete upper limb model previously. Because the upper limb structure is complex, the previous model is so simplified that soft tissue structure is not considered. It cannot reflect the change and distribution of the stress and stress state during elbow flexion exercise.
Methods

From the perspective of biomechanics, based on the CT scanning images of forearm for an aged female volunteer, a 3-D distal radius fracture forearm model is established. By introducing the soft tissues and the splint, a complete 3-D forearm model is finally reconstructed. The model includes ulna, radius, humerus, muscle, ligament, joint, wrist, skin and splint. The correctness of the model is verified by comparing the results of numerical simulation with the results of previous literature and clinical experiments.
Results

When the elbow flexion angle increases from 0 to 120 degrees, the stress increases from 0.21 Mpa to 0.83 Mpa. When the elbow flexion angle increases from 0 to 120 degrees, the strain increases from 2–23%, and the maximum strain at the fracture end is about 22.5%. Also an analytical formula of the relationship fracture end strain and different elbow flexion angles is obtained by nonlinear fitting based on the simulation results, which is convenient for clinicians to predict fracture end strain.
Conclusions

During elbow flexion rehabilitation exercise, the stress of biceps brachii is large, and with the increase of elbow flexion angle, the stress shows an increasing trend. The stress in the area of distal radius fracture is also concentrated. Moderate stress concentration is helpful to the process of bone remodeling, so as to shorten the time of fracture healing. There was no obvious stress concentration in metacarpal bone and has little effect on the activity of metacarpophalangeal joint. The fretting strain at the fracture site can improve the speed of fracture healing, because the generation of early callus can absorb a lot of energy generated by fretting strain, which has an impact on the mechanical properties and plastic deformation ability of callus, and plays an important role in the stimulation of late osteogenesis.
Association of Serum Calcium Levels with Renal Impairment and All-Cause Death in Chinese Patients with Newly Diagnosed Multiple Myeloma: A Cross-Sectional, Longitudinal Study
Authors: Cheng Jun , Zhang Wen , Zhao Yi , Li Xiayu , Lv Rong , Li Heng , Chen Jianghua 
Published: June 2020

Abstract
Background: A number of studies have shown that serum calcium has a crucial role in many types of cancers. However, few studies have determined the association between serum calcium levels and renal impairment (RI) and all-cause death in Chinese patients with multiple myeloma (MM).Methods: Two hundred forty-six of 566 participants who were followed for > 6 months from a MM cohort at our institution between January 2011 and June 2017 were eligible for the retrospective study. A generalized additive model and smooth curve fitting were conducted to investigated the cross-sectional relationship between serum calcium level and RI and eGFR at baseline；Multivariate-adjusted Cox regression models were fitted to assess associations between baseline serum calcium levels and onset of end-stage renal disease(ESRD) or death in patients with MM followed for > 6 months.Results: Using the IMWG criteria,162 of 566 patients (28.6%) with newly diagnosed MM presented with RI . The mean duration of follow-up was 26.64 months. Twenty-one patients (8.54%) died and 28 patients（11.52%）had ESRD.The serum calcium level was independently associated with the occurrence of MM-related RI. There was a non-linear relationship between the serum calcium level and the presence of RI in patients with MM in the cross-sectional analysis of the baseline data. Cox regression analysis showed that baseline serum calcium levels were consistently associated with a higher risk of all-cause death after adjustment for various clinical and laboratory factors, but were not associated with the occurrence of ESRD. When patients were categorized into 2 groups according to baseline mean serum calcium level, deaths occurred in 13 patients (15.1%) with mean serum calcium level > 2.44 mmol/L compared to 8 patients (5.0%) with mean serum calcium level < 2.44 mmol/L (p < 0.05); Eighteen patients (11.46%) with a mean serum calcium level < 2.44 mmol/L progressed to ESRD compared to 13 patients (11.6%) with a serum calcium level > 2.44 mmol/L (p > 0.05).Conclusions: This observational study showed that there was a non-linear relationship between the serum calcium level and the occurrence of RI. An elevated baseline calcium level can predict all-cause death in patients with MM, but cannot predict the occurrence of ESRD, suggesting that the serum calcium level may serve as a useful clinical biomarker for the survival rate of patients with MM followed for > 6 months. Additional data from larger prospective longitudinal studies are required to validate our findings.
Dynamic Clinical Features During the Para-Exacerbation Period of Critical COVID-19 Patients
Authors: Bao Aihua , Zhou Yan , Yunfei Lu , Qiao Lihua , Ding Fengming , Lu Hongzhou , Zhang Min 
Published: June 2020

Abstract
Background COVID-19 has been currently spread all over the world with high mortality reported in severe COVID-19 patients. Many severe COVID-19 patients exacerbated from mild illness several days after hospital admissions. Pathophysiological evolution within this para-exacerbation period remain unclear.Methods Twenty-two confirmed COVID-19 patients who underwent at least one exacerbation were included. Epidemiological, clinical, laboratory, and radiological data were extracted from electronic medical records and compared between the records of hospital admission day and the exacerbation day. Dynamic profiles of critical parameters were explored during the para-exacerbation period.Results Most of the patients were elder (67, IQR63-79), male (81.8%), coexisted with comorbidities (72.7%), multi-segments radiologically involved and exacerbated from mild to severe illness with anoxia at a median interval of 4 days (IQR, 2-7) from hospital admissions. On exacerbations, various clinical parameters were worsened, including respiratory rate, PaO2/FiO2 rate (PFR), alveolar-arterial PO2 difference (A-aDO2), hematological cellularities, biochemical parameters and radiological abnormalities. Dynamic profiles showed that neutrophil/lymphocyte ratio (NLR), and serum level of lactic acid, lactate dehydrogenase and coagulation parameters started to increase even at four days before the exacerbation.Conclusions Anoxia due to impaired gas exchange progress pathophysiologically characterized the exacerbation of COVID-19 patients. Continuously monitoring crucial clinical parameters, such as NLR, serum albumin, LDH, lactic acid, and CT involvement scale will be helpful to improve the recognition of the disease progression in patients with COVID-19 at early stage.Trial registration: This retrospective study has been registered in Chinese Clinical Trial Registry (ChiCTR2000030580, www.chictr.org.cn)
Long-Term Follow-up of a Homozygous Familial Hypercholesterolemia Child with Progressive Aortic Stenosis and Coronary Atherosclerosis
Authors: Cai Gaojun , Jiang Long , Yang Ya , Sun Liyuan , Wang Xu , Zhou Yujie , Wang Lvya 
Published: June 2020

Abstract
Familial hypercholesterolemia (FH) is a severe autosomal-dominant disorder. We reported a case who firstly admitted to our institution for obvious cutaneous and tendinous xanthomas and high low-density lipoprotein cholesterol when he was 3.7 year old in 2005. DNA sequencing detected the homozygous mutation in LDLR exon9 c.1187-10G>A, a 3' splice acceptor mutation in poly-pyrimidine tract of intron 8. During the long-term follow-up, progressive aortic stenosis and coronary atherosclerosis was found, although given the lipid-lowing drugs. HoFH with c.1187-10G>A mutation in LDLR gene might lead to severe damage in cardiovascular system and unsatisfactory response to conventional lipid-lowing drugs. Other aggressive treatments should be used in HoFH patients with this mutation as early as possible.
Gross Hematuria in Patients with Wasp Sting: A Retrospective Study
Authors: wang wei , Wang Maohe , singh Prince , Tang Yong , Zhong Xiang , Chen Shasha , Li Guisen , Wang Li 
Published: June 2020

Abstract
Background: Wasp sting is common in the world, and gross hematuria after wasp sting has been reported in Asia to occur before AKI. Gross hematuria is often used by clinicians as a sign indicated for intensive care and blood purification treatment. However, there is no study on the clinical characteristics and prognosis of wasp sting patients complicated with gross hematuria. Methods: The demographic characteristics and clinical data of 363 patients with wasp sting admitted to Suining Central Hospital from January 2016 to December 2018 were retrospectively analyzed. At admission, the poisoning severity score was used as the criterion for severity classification. According to the presence of gross hematuria, the patients were divided into gross hematuria group and non-gross hematuria group. Multivariate logistic regression analysis was performed to explore the risk factors for gross hematuria.Results: Of the 363 wasp sting patients, 219 were male and 144 were female, mean age was 55.9±16.3 years. 51 (14%) had gross hematuria, 39(10.7%) had Acute Kidney Injury(AKI), 105 (28.9%) had rhabdomyolysis, 61(16.8%) had hemolysis, 56 (15.4%) had Multiple Organ Dysfunction Syndrome (MODS), 13 (3.6%) had Acute Respiratory Distress Syndrome (ARDS), 45(12.4%) went on to receive renal replacement therapy, and 14 (3.9%) died. Patients with gross hematuria group had significantly higher poisoning severity scores when admitted to the hospital than those without gross hematuria group (2.2±0.5 vs. 1.1±0.3, P<0.001).Conclusion: Gross hematuria is one of the early clinical symptoms of severe wasp sting patients. AKI incidence and mortality of patients with gross hematuria are significantly increased. Prompt treatment should be taken for wasp sting patients complicated with gross hematuria. The poisoning severity score can be used for early assessment of the severity of wasp sting patients.
Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention
Authors: Claire Ravinder , Gluud Christian , Berlin Ivan , Coleman Tim , Leonardi-Bee Jo 
Published: June 2020

Abstract
Background
Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the design and sample size of the adequately powered randomised clinical trials. When a randomised clinical trial is conducted, results from feasibility and pilot trials may be disregarded in terms of benefits and harms.
Methods
We describe using feasibility and pilot trial data in the Trial Sequential Analysis program to estimate the required sample size for one or more trials investigating a behavioural smoking cessation intervention. We show how data from a new, planned trial can be combined with data from the earlier trials using Trial Sequential Analysis to assess the intervention’s effects.
Results
We provide a worked example to illustrate how we successfully used Trial Sequential Analysis methods to argue for the research funds needed to undertake a randomised clinical trial.
Conclusions
Trial Sequential Analysis can utilise data from feasibility and pilot trials as well as other trials, to estimate a sample size for one or more future randomised clinical trials. As this method uses available data, estimated sample sizes may be smaller than they would have been using conventional sample size estimation methods.
The role of andrographolide and its derivative in COVID-19 associated proteins and immune system
Authors: Dey Yadu Nandan , Khanal Pukar , Patil B. M. , Wanjari Manish M. , Srivast Bhavana , Gurav Shailendra S. , Gaidhani Sudesh N. 
Published: June 2020

Abstract
Aim: In view of the strong immunomodulatory and antiviral activity of andrographolide and its derivative, the present study aimed to investigate the binding affinities of andrographolide and its derivative 14-deoxy-11,12-didehydroandrographolide with 3 major targets of COVID-19 i.e. 3CLpro, PLpro and spike protein followed by their gene-set enrichment analysis with special reference to immune modulation.Materials and methods: SMILES of the compounds were retrieved from DigepPred database and the proteins identified were queried in STRING to evaluate the protein-protein interaction and modulated pathways were identified concerning the KEGG database. Drug-likeness and ADMET profiles were evaluated using MolSoft and admet SAR 2.0, respectively. Molecular docking was carried using autodock 4.0.Results: Andrographolide and 14-Deoxy-11,12-didehydroandrographolide were predicted to have a high binding affinity with papain-like protease i.e. -6.7 kcal/mol and -6.5 kcal/mol, respectively while they interact with equal binding energies with 3clpro (-6.8 kcal/mol) and spike protein (-6.9 kcal/mol). Network pharmacology analysis revealed that both compounds modulated the immune system through the regulation of chemokine signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, MAPK signaling pathway, NF-kappa B signaling pathway, Rassignaling pathway, p53 signaling pathway, HIF-1 signaling pathway, and Natural killer cell-mediated cytotoxicity. Although the 14-deoxy-11,12-didehydroandrographolide scored higher drug-likeness character, it showed less potency to interaction with targeted proteins of COVID-19.Conclusion: The study suggests the strong interaction of the andrographolide and its derivative 14-deoxy-11,12-didehydroandrographolide against target proteins associated with COVID-19. Further, network pharmacology analysis elucidated the different pathways of immunomodulation. However, clinical research should be conducted to confirm the current findings.
Education in a new place and social support are needed to improve the health of North Korean defectors: A cross-sectional study
Authors: Lee Jihyun , Park Yui , HAN DONGHUN , Yoo Ji Won , Zhou Wenlian , Kim Pearl , Shen Jay J. 
Published: June 2020

Abstract
Background

The number of North Korean defectors (NKDs) escaping to South Korea has increased. The health status of NKDs is an essential factor for a successful settlement into South Korean society. However, no studies have been conducted on the health status of NKDs in terms of education and social support. The aim of this study was to determine the effects of education and social support on the self-rated health status among NKDs.

Methods

This study utilized data gained from face-to-face interviews with 126 NKDs. A multivariable logistic regression and path analysis were performed to assess the effects of education in South Korea and social support with their self-rated health status and to explore the complex relationships between direct and indirect effects of the variables.

Results

NKDs who did not experience regular education in South Korea responded that they were in poor health compared to their counterpart (OR=5.78). Although a direct association between education in South Korea and self-rated health was not shown, there was an indirect path from education in South Korea to self-rated health through social support.

Conclusions

Participation in regular education is important for the health status of NKDs. Social policies and NKD assistance programs should consider and reflect the combination of education and social support interventions relevant to the health status of NKDs.
The Clinical and Translational Research Activities at the INT – IRCCS “Fondazione Pascale” Center (Naples, Italy) during the COVID-19 Pandemic
Authors: Buonaguro Franco M. , Botti Gerardo , Ascierto Paolo Antonio , Pignata Sandro , Ionna Franco , Delrio Paolo , Petrillo Antonella , Cavalcanti Ernesta , Bonito Maurizio Di , Perdonà Sisto , De Laurentiis Michelino , Fiore Francesco , Palaia Raffaele , Izzo Francesco , D'Auria Stefania , Rossi Virginia , Menegozzo Simona , Piccirillo Mauro , Celentano Egidio , Cuomo Arturo , Normanno Nicola , Tornesello Maria Lina , Saviano Rocco , Barberio Daniela , Buonaguro Luigi , Miscio Leonardo , Bianchi Attilio Antonio Montano 
Published: June 2020

Abstract
COVID-19 pandemic following the outbreak in China and Western Europe, where it finally lost the momentum, is now devastating North and South America. It has not been identified the reason and the molecular mechanisms of the two different patterns of the pulmonary host responses to virus from a minimal disease in young subjects to a severe distress syndrome (ARDS) in older subjects, particularly those with previous chronic diseases (including diabetes) and Cancer. The Management of the Istituto Nazionale Tumori - IRCCS “Fondazione Pascale” in Naples [INT-Pascale], along with all Health professionals decided not to interrupt the treatment of those hospitalized and to continue, even if after a careful triage in order not to allow SARS-CoV-2 positive subjects to access, to take care of cancer patients with serious conditions. Although very few (n=3) patients developed a symptomatic COVID-19 and required the transfer to a COVID-19 area of the Institute, no patients died during the Hospitalization and completed their oncology treatment. Besides monitoring of the patients, all employees of the Institute (physicians, nurses, researchers, lawyers, accountants, gatekeepers, guardians, janitors) have been tested for a possible exposure. Personnel identified as positive, has been promptly subjected to home quarantine and subdued to health surveillance. One severe case of respiratory distress has been reported in a positive employees and one death of a family member. Further steps to home monitoring of COVID-19 clinical course have been taken with the development of remote Wi-Fi connected digital devices for the detection of early signs of respiratory distress, including heart rate and oxygen saturation.
In conclusion cancer care has been performed and continued safely also during COVID-19 pandemic and further remote home strategies are in progress to ensure the appropriate monitoring of cancer patients.