bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed facies analysis of Cenomanian–Turonian organic‐rich mudstones: Implications for depositional controls on source rocks
Authors: Percy Emma L. , Pedersen Per K. 
Published: January 2020

AbstractUnderstanding mudstone depositional processes, including both traction transport and dynamic mechanisms, requires a re‐assessment of how these processes relate to the accumulation and preservation of organic carbon in fine‐grained successions. This relationship was addressed using facies described in detail from a Cenomanian–Turonian aged, organic‐rich, marine mudstone‐dominated succession from the Albertan Western Interior Seaway. All facies exhibit a high degree of heterogeneity at the millimetre‐to‐decimetre scale, contain evidence of bioturbation and display similar ranges of sedimentary structures including wave ripples and current ripples, sharp‐based graded beds and starved ripples. Described facies vary in grain size as well as relative abundances of biogenic versus siliciclastic grains. Siliciclastic grains are dominantly composed of quartz silt as well as silt‐sized to sand‐sized clay mineral–rich aggregates while the biogenic grains are dominantly composed of silt‐sized to sand‐sized calcareous pellets, bivalve fragments and foraminifera. Although the succession is relatively clay mineral‐rich, the majority of clay minerals occur as mud aggregates that were transported by traction processes. The sedimentary structures present are diagnostic of sea floor reworking by waves and currents, indicating that the basin was relatively shallow (i.e. not hundreds of metres deep) with frequent reworking of the sea floor sediment with suspension settling deposits being rare. The abundance of bioturbation and in situ bivalves indicates that there was sufficient oxygen at the sea floor and that widespread bottom water anoxia was not persistent at the time of deposition of the organic‐rich interval of interest. The accumulation of organic‐rich sediment appears to be a preservational phenomenon caused by sediment being buried more rapidly than the organic carbon can oxidize in the surficial layers due to episodic inputs of siliciclastic material during large storm events.
Rapid peat development beneath created, maturing mangrove forests: ecosystem changes across a 25‐yr chronosequence
Authors: Osland Michael J. , Feher Laura C. , Spivak Amanda C. , Nestlerode Janet A. , Almario Alejandro E. , Cormier Nicole , From Andrew S. , Krauss Ken W. , Russell Marc J. , Alvarez Federico , Dantin Darrin D. , Harvey James E. , Stagg Camille L. 
Published: January 2020

AbstractMangrove forests are among the world's most productive and carbon‐rich ecosystems. Despite growing understanding of factors controlling mangrove forest soil carbon stocks, there is a need to advance understanding of the speed of peat development beneath maturing mangrove forests, especially in created and restored mangrove forests that are intended to compensate for ecosystem functions lost during mangrove forest conversion to other land uses. To better quantify the rate of soil organic matter development beneath created, maturing mangrove forests, we measured ecosystem changes across a 25‐yr chronosequence. We compared ecosystem properties in created, maturing mangrove forests to adjacent natural mangrove forests. We also quantified site‐specific changes that occurred between 2010 and 2016. Soil organic matter accumulated rapidly beneath maturing mangrove forests as sandy soils transitioned to organic‐rich soils (peat). Within 25 yr, a 20‐cm deep peat layer developed. The time required for created mangrove forests to reach equivalency with natural mangrove forests was estimated as (1) <15 yr for herbaceous and juvenile vegetation, (2) ~55 yr for adult trees, (3) ~25 yr for the upper soil layer (0–10 cm), and (4) ~45–80 yr for the lower soil layer (10–30 cm). For soil elevation change, the created mangrove forests were equivalent to or surpassed natural mangrove forests within the first 5 yr. A comparison to chronosequence studies from other ecosystems indicates that the rate of soil organic matter accumulation beneath maturing mangrove forests may be among the fastest globally. In most peatland ecosystems, soil organic matter formation occurs slowly (over centuries, millennia); however, these results show that mangrove peat formation can occur within decades. Peat development, primarily due to subsurface root accumulation, enables mangrove forests to sequester carbon, adjust their elevation relative to sea level, and adapt to changing conditions at the dynamic land–ocean interface. In the face of climate change and rising sea levels, coastal managers are increasingly concerned with the longevity and functionality of coastal restoration efforts. Our results advance understanding of the pace of ecosystem development in created, maturing mangrove forests, which can improve predictions of mangrove forest responses to global change and ecosystem restoration.
Climate connectivity of the bobcat in the Great Lakes region
Authors: Marrotte Robby R. , Bowman Jeff , Wilson Paul J. 
Published: January 2020

AbstractThe Great Lakes and the St. Lawrence River are imposing barriers for wildlife, and the additive effect of urban and agricultural development that dominates the lower Great Lakes region likely further reduces functional connectivity for many terrestrial species. As the climate warms, species will need to track climate across these barriers. It is important therefore to investigate land cover and bioclimatic hypotheses that may explain the northward expansion of species through the Great Lakes. We investigated the functional connectivity of a vagile generalist, the bobcat, as a representative generalist forest species common to the region. We genotyped tissue samples collected across the region at 14 microsatellite loci and compared different landscape hypotheses that might explain the observed gene flow or functional connectivity. We found that the Great Lakes and the additive influence of forest stands with either low or high canopy cover and deep lake‐effect snow have disrupted gene flow, whereas intermediate forest cover has facilitated gene flow. Functional connectivity in southern Ontario is relatively low and was limited in part by the low amount of forest cover. Pathways across the Great Lakes were through the Niagara region and through the Lower Peninsula of Michigan over the Straits of Mackinac and the St. Marys River. These pathways are important routes for bobcat range expansion north of the Great Lakes and are also likely pathways that many other mobile habitat generalists must navigate to track the changing climate. The extent to which species can navigate these routes will be important for determining the future biodiversity of areas north of the Great Lakes.
Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction
Authors: Zhou Jingmin , Cao Juan , Jin Xuejuan , Zhou Jun , Chen Zhenyue , Xu Dingli , Yang Xinchun , Dong Wei , Li Liwen , Fan Yuyuan , Chen Li , Zhong Qiaoqing , Fu Micheal , Hu Kai , Ge Junbo ,   CN‐HF investigators
Published: January 2020

AbstractAimsThe aim of this study was to investigate the impact of digoxin use on the outcomes of patients with heart failure with reduced ejection fraction (HFrEF) and its possible interaction with atrial fibrillation or use of currently guideline‐recommended treatments in the real world in China.Methods and resultsPatients hospitalized with HFrEF from 45 hospitals participating in the China National Heart Failure Registration Study (CN‐HF) were enrolled to assess the all‐cause mortality, HF mortality, all‐cause re‐hospitalization, and HF re‐hospitalization associated with digoxin use. Eight hundred eighty‐two eligible HFrEF patients in the CN‐HF registry were included: 372 patients with digoxin and 510 patients without digoxin. Among them, 794 (90.0%) patients were followed up for the endpoint events, with a median follow‐up of 28.6 months. Kaplan–Meier survival analysis showed that the all‐cause mortality (P < 0.001) and all‐cause re‐hospitalization (P = 0.020) were significantly higher in digoxin group than non‐digoxin group, while HF mortality (P = 0.232) and HF re‐hospitalization (P = 0.098) were similar between the two groups. The adjusted Cox proportional‐hazards regression analysis demonstrated that digoxin use remained as an independent risk factor for increased all‐cause mortality [hazard ratio (HR) 1.76; 95% confidence interval (CI) 1.27–2.44; P = 0.001] and all‐cause re‐hospitalization (HR 1.27; 95% CI 1.03–1.57; P = 0.029) in HFrEF patients and the predictive value of digoxin for all‐cause mortality irrespective of rhythm or in combination with other guideline‐recommended therapies.ConclusionsDigoxin use is independently associated with increased risk of all‐cause mortality and all‐cause re‐hospitalization in HFrEF patients.
Intractable coronary fibromuscular dysplasia leading to end‐stage heart failure and fatal heart transplantation
Authors: Cattaneo Magdalena Maria , Moccetti Marco , Cattaneo Mattia , Sürder Daniel , Suter Thomas , Martinelli Michele , Roost Eva , Schmidli Jürg , Banz Yara , Schneiders Carmen , Pedrazzini Giovanni , Corti Roberto , Räber Lorenz , Crea Filippo , Mohacsi Paul , Gallino Augusto 
Published: January 2020

AbstractCoronary fibromuscular dysplasia is uncommon, and even rarer its unstable and recurrent course. We present the unique case of a 52‐year‐old woman who underwent in total 12 coronary angiographies and three percutaneous coronary intervention within 24 months because of repetitive acute coronary syndromes due to refractory spasm, dissection, restenosis all leading to end‐stage heart failure, and heart transplantation. The patient died 12 days after the heart transplantation complicated by intraoperative acute thrombotic occlusion of left anterior descending artery of the graft despite normal pretransplant coronary angiography. Autopsy of the recipient heart confirmed coronary fibromuscular dysplasia with massive intimal hyperplasia and restenosis.
Voltammetric Label‐free Immunosensors for the Diagnosis of Cystic Echinococcosis
Authors: Eissa Shimaa , Noordin Rahmah , Zourob Mohammed 
Published: January 2020

AbstractCystic echinococcosis (CE) or hydatid disease is a parasitic infection caused by Echinococcus granulosus. Early serodiagnosis and continuous monitoring of the disease is very important for medical treatment. Here, we report the detecting of both echinococcus antigen and antibody for the diagnosis of hydatid disease using square wave voltammetry (SWV)‐based immunosensors. The gold electrodes were functionalized using cysteamine/phenylene diisothiocyanate linkers and used for the immunosensors fabrication. The hydatid antigen and antibody immunosensors were constructed by the immobilization of either purified rabbit polyclonal antibody or recombinant antigen B (AgB), respectively on the functionalized gold electrodes surfaces. The detection in both cases was achieved by following the change in the SWV reduction peak current of the ferro/ferricyanide redox couple upon antibody or antigen binding. These immunosensors enabled the detection of echinococcus antigen and antibody within a concentration range of 1 pg.mL−1 to 1 μg.mL−1 with detection limits of 0.4 pg.mL−1 and 0.3 pg.mL−1, respectively. A preliminary application of the developed immunosensor was performed in spiked serum sample showing good recovery percentages ranging from 102 to 110 % for both hydatid antibody and antigen detection. This easy‐to‐use, sensitive, and low cost quantitative method holds great promise for the early diagnosis of hydatid disease and thus, better managements and treatment outcomes.
Pore‐scale visualization and quantitative analysis of the spontaneous imbibition based on experiments and micro‐CT technology in low‐permeability mixed‐wettability rock
Authors: Liu Qiang , Song Rui , Liu Jianjun , Lei Yun , Zhu Xingyu 
Published: January 2020

AbstractThe pore‐scale imbibition mechanism in fractured water‐wetted reservoirs has been acknowledged as an efficient tool to enhance oil recovery. Most rock in a natural reservoir is mixed‐wetted, but most studies on the pore‐scale imbibition process only focused on the water‐wetted rock. This paper adopts two mixed‐wetted core samples for microspontaneous imbibition experiment, micro‐CT scanning, and nuclear magnetic resonance (NMR) test. The results indicate that the pore radius distribution of the segmented CT images is consistent with that of the NMR test. The microimbibition recovery ratio of core No. 34‐1 and core No. 64 in the spontaneous imbibition experiment are 27.7% and 58.2%, which agrees well with that computed by the micro‐CT scanning image (27.63% and 56.09%). Based on the segmented images, the influences of the Jamin's effect, pore size distribution, and wettability on the microspontaneous imbibition are visualized and quantitatively studied. The Jamin's effect is the important factor that hinders the microimbibition process. The main pore size of imbibition distributes in the range of 1‐25 μm. Furthermore, the pore‐scale spontaneous imbibition process in a single pore with mixed wettability is investigated and analyzed. The relationships among the contact angle, capillary force, recovery ratio, wettability, and the microimbibition recovery are revealed.
Laboratory and theoretical evaluation of impact of packing density, particle shape, and uniformity coefficient on erodibility of coarse‐grained soil particles
Authors: Choo Hyunwook , Zhao Qian , Burns Susan E. , Sturm Terry W. , Hong Seung Ho 
Published: January 2020

AbstractSedimentation – including erosion, transport, and deposition of coarse‐grained particles – is a primary and growing environmental, engineering, and agricultural issue around the world. Soil erosion occurs when the hydrodynamic force induced by flowing water exceeds the geotechnical resistance of soils, as measured by critical shear stress for initiation of soil‐particle motion. Even though various quantitative methods have been suggested with respect to different types of soil, the most widely accepted formula to estimate critical shear stress for coarse‐grained soil is a direct function of the median grain size of the soil particles; however, the erosion resistance of soils also varies with other geotechnical properties, such as packing density, particle shape, and uniformity coefficient. Thus, in this study, a combined rolling–lift model for particle detachment was derived based on theoretical analysis. A series of experimental flume tests were conducted with specimens prepared with standard soil types, as well as laboratory‐prepared mixtures of coarse‐grained soil to validate the theoretical model and determine the effect of other geotechnical properties on the erosion characteristics of coarse grains, coupled with the effect of median particle size. The results indicated that the median grain size is the primary variable determining the resistance of coarse grains, but the critical shear stress also varies with the packing density of the soil matrix. In addition, angular particles show more erosion resistance than rounded particles, and the erosion potential of a soil decreased when the grain is well graded (higher value of uniformity coefficient). Additionally, regression analysis was performed to quantify the effect of each parameter on the critical shear stress of coarse grains. © 2020 John Wiley & Sons, Ltd.
A national rockfall dataset as a tool for analysing the spatial and temporal rockfall occurrence in Germany
Authors: Rupp Stefan , Damm Bodo 
Published: January 2020

AbstractThis study presents an evaluation of a comprehensive dataset with information on about 700 recorded rockfall events in Germany for the first time. The focus is on the analysis of monthly distributions of three rockfall clusters in German low mountain ranges and of three elevation classes to provide an overview of the characteristic seasonal occurrence of rockfalls in Germany. Each rockfall distribution is correlated with records of meteorological station clusters which are representative for the long‐term climate conditions of the particular rockfall cluster and elevation class, respectively. The stored parameters in the dataset (year of occurrence, rock volumes, slope angles, affected objects) are evaluated to complete the extensive and differentiated overview of rockfalls in Germany. The analyses of the distributions of the three rockfall clusters show a distinct event concentration in the winter months. Differences are apparent between the monthly distributions of the elevation classes in which clear peaks are partially visible. Freeze–thaw cycles are considered to be the major trigger of winter rockfalls in Germany. Overall, the presented results may serve as a basis for further studies in the German low mountain ranges. © 2020 John Wiley & Sons, Ltd.
Optimized extraction and quality evaluation of Niger seed oil via microwave‐pulsed electric field pretreatments
Authors: Mohseni Nazanin Maryam. , Mirzaei Habibollah , Moghimi Masoumeh 
Published: January 2020

AbstractIn this study, oil extraction from Niger seeds was evaluated with different microwave irradiation times (0–200 s) and pulsed electric fields (PEF) intensities (0–5 kV/cm) as pretreatments. Then, oil extraction was completed with a screw press at different rotation speeds (11–57 rpm). Quality parameters including extraction efficiency, acidity and peroxide values (PVs), chlorophyll, and phenolic contents along with fatty acid profiles and tocopherol levels of the extracted oils were determined as responses. With enhancements in microwave time, PEF intensity and press rotation, the chlorophyll contents, acidity/PVs, and total phenolics of oils increased similar to oil extraction efficiency although it was reduced later. The optimized conditions selected by response surface methodology were determined as 156.23 s, 1.18 kV/cm, and 20 rpm for microwave time, PEF intensity and press speed, respectively. Fatty acid analysis revealed that linoleic acid was the most predominant fatty acid in the extracted oil. Application of the mentioned pretreatments may lead to a reduction in unsaturated fatty acids and escalation of saturated ones (p < .05). High‐performance liquid chromatography results indicated that α‐tocopherols are the most common tocopherols in Niger seed oil and microwave‐PEF pretreatments may lead to 2.79% increase in tocopherols content.
Serial Transient Elastography Examinations to Monitor Patients With Type 2 Diabetes: A Prospective Cohort Study
Authors: Lee Hye Won , Wong Grace Lai‐Hung , Kwok Raymond , Choi Kai Chow , Chan Carmen Ka‐Man , Shu Sally She‐Ting , Leung Julie Ka‐Yu , Chim Angel Mei‐Ling , Luk Andrea On‐Yan , Ma Ronald Ching‐Wan , Chan Henry Lik‐Yuen , Chan Juliana Chung‐Ngor , Kong Alice Pik‐Shan , Wong Vincent Wai‐Sun 
Published: January 2020

Background and Aims
Type 2 diabetes is an important risk factor for nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis. Current international guidelines recommend the use of noninvasive tests as initial assessments for NAFLD, but the role of noninvasive tests as monitoring tools has not been established. We aimed to study the role of transient elastography as a monitoring tool in patients with type 2 diabetes.

Approach and Results
We recruited patients with type 2 diabetes without viral hepatitis or excessive alcohol intake from a complication screening facility in Hong Kong in 2013‐2014 and repeated the assessments in 2016‐2018. The primary endpoint was an increase of liver stiffness measurement (LSM) to ≥10 kPa. The secondary endpoint was the change in the controlled attenuation parameter (CAP). A total of 611 patients with type 2 diabetes and a valid LSM (mean age, 57.7 ± 10.9 years; 342 men [56.0%]) were included in this study (568 also had a valid CAP). Overall, there was moderate correlation between the baseline and follow‐up LSM (r = 0.689, P < 0.001). Among 487 patients with a baseline LSM <10 kPa, 21 (4.3%) had a follow‐up LSM ≥10 kPa. Baseline body mass index, alanine aminotransferase (ALT), and ∆ALT were independent factors associated with LSM increase. Among 124 patients with a baseline LSM ≥10 kPa, 70 (56.5%) had a follow‐up LSM <10 kPa. Among 198 patients with a CAP <248 dB/m at baseline, 103 (52.0%) had a CAP increased to ≥248 dB/m.

Conclusions
The prevalence and incidence of NAFLD in patients with type 2 diabetes are high. Although advanced fibrosis is common in this population, few patients progress to advanced fibrosis in 3 years. Future studies should define the optimal surveillance interval in patients with diabetes.
Stochastic hybrid decision‐making based on interval type 2 fuzzy sets for measuring the innovation capacities of financial institutions
Authors: Jun Qi , Dinçer Hasan , Yüksel Serhat 
Published: January 2020

AbstractThis study aims to construct a hybrid decision‐making approach to the stochastic evaluation for the innovation capacity of financial institutions. For this purpose, interval type 2 fuzzy DEMATEL‐ANP is used for weighting the criteria and dimensions. Additionally, TOPSIS and VIKOR methods based on interval type 2 fuzzy sets are considered to rank the alternatives. The novelty of the study is to propose a set of criteria and dimensions of innovation capacity with the supported literature. Another novelty is to propose an extended method of DEMATEL‐ANP by using interval type 2 fuzzy sets as well as an integrated method of interval type 2 fuzzy stochastic decision‐making with the Monte Carlo simulation. The results indicate that organizational dimension of innovation capacities has the highest importance between the set of criteria and the state‐owned banks have been more appropriate than both the private and foreign banks for generating the innovation capacities in the financial institutions. However, the analysis illustrates that stochastic decision‐making models could provide more extensive results than the conventional methods including the expert priorities. This study could be also extended by using different multicriteria decision‐making methods such as MOORA and ELECTRE and also, the cross‐country analysis could be applied for the future studies.
Putative promoters within gene bodies control exon expression via TET1‐mediated H3K36 methylation
Authors: Ma Ling , Muhammad Tahir , Wang Hongyang , Du Guangyuan , Sakhawat Ali , Wei Yazi , Ali Khan Aamir , Cong Xianling , Huang Yinghui 
Published: January 2020

AbstractHypermethylation of gene promoter has been indicated for the contribution of gene silencing, and DNA demethylating drugs, such as 5‐aza‐2'‐deoxycytidine (DAC), has been used clinically for cancer treatment. However, the reason why a proportion of genes with hypermethylated promoter exhibit high expression levels remains unclear and this drug is not much successful as expected in use. Furthermore, CpG islands (CGIs) are found to be located in not only promotors, but also in gene bodies. By RNA‐seq and reduced representation bisulfite sequencing, we found the mismatch between the level of promoter methylation and gene expression. By chromatin Immunoprecipitation‐quantitative polymerase chain reaction and luciferase reporter assay, we identified putative promoters in gene body, and proved the activities of putative promoters were affected by the methylation level of the CGI nearby. DAC can reverse the DNA hypermethylation at promoter CGIs effectively but not the CGIs in gene body. We also found that TET1 could demethylate CGIs both in promoter and gene body. Furthermore, we revealed a novel mechanism that H3K36me3 could affect the activity of putative promoter, and 5hmC recruited MeCP2 and CREB1 as a coactivator to SETD2 promoter, to enhance its gene expression and result in increased H3K36me3 in gene body. Our results concluded that putative promoters existed in the gene bodies, and TET1 could influence the transcriptional activity of putative promoters by intragenic demethylation.