bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
Authors: Dwyer-Nield Lori D. , McArthur Debbie G. , Tennis Meredith A. , Merrick Daniel T. , Keith Robert L. 
Published: October 2020

AbstractTobacco smoke-induced squamous cell lung cancer (SCC) develops from endobronchial dysplastic lesions that progress to invasive disease. A reproducible murine model recapitulating histologic progression observed in current and former smokers will advance testing of new preventive and therapeutic strategies. Previous studies show that prolonged topical application of N-nitroso-tris-chloroethylurea (NTCU) generates a range of airway lesions in sensitive mice similar to those induced by chronic tobacco smoke exposure in humans. To improve the current NTCU model and better align it with human disease, NTCU was applied to mice twice weekly for 4–5 weeks followed by a recovery period before cigarette smoke (CS) or ambient air (control) exposure for an additional 3–6 weeks. Despite the short time course, the addition of CS led to significantly more premalignant lesions (PML; 2.6 vs. 0.5; P &lt; 0.02) and resulted in fewer alveolar macrophages (52,000 macrophages/mL BALF vs. 68,000; P &lt; 0.05) compared with control mice. This improved NTCU + CS model is the first murine SCC model to incorporate tobacco smoke and is more amenable to preclinical studies because of the increased number of PML, decreased number of mice required, and reduced time needed for PML development.
Cancelation of Deglacial Thermosteric Sea Level Rise by a Barosteric Effect
Authors: Gebbie Geoffrey 
Published: October 2020

AbstractSea level rise over the last deglaciation is dominated by the mass of freshwater added to the oceans by the melting of the great ice sheets. While the steric effect of changing seawater density is secondary over the last 20 000 years, processes connected to deglacial warming, the redistribution of salt, and the pressure load of meltwater all influence sea level rise by more than a meter. Here we develop a diagnostic for steric effects that is valid when oceanic mass is changing. This diagnostic accounts for seawater compression due to the added overlying pressure of glacial meltwater, which is here defined to be a barosteric effect. Analysis of three-dimensional global seawater reconstructions of the last deglaciation indicates that thermosteric height change (1.0–1.5 m) is counteracted by barosteric (−1.9 m) and halosteric (from −0.4 to 0.0 m) effects. The total deglacial steric effect from −0.7 to −1.1 m has the opposite sign of analyses that assume that thermosteric expansion is dominant. Despite the vertical oceanic structure not being well constrained during the Last Glacial Maximum, net seawater contraction appears robust as it occurs in four reconstructions that were produced using different paleoceanographic datasets. Calculations that do not account for changes in ocean pressure give the misleading impression that steric effects enhanced deglacial sea level rise.
Personal Health Budget as a new rehabilitation model for severe mental illness within a caring community: An Italian evaluation study of beneficial effects
Authors: Pelizza Lorenzo , Leuci Emanuela , Landi Giulia , Maestri Davide , Paulillo Giuseppina , Ceroni Patrizia , Soncini Caterina , Daolio Maria Cristina , Quattrone Emanuela , Pellegrini Pietro 
Published: October 2020

Objective: Personal Health Budget has been provided to consumers with severe mental illness within a policy shift toward a person-tailored mental healthcare treatment based on individual unmet needs. Evidence of beneficial effects of Personal Health Budget is still scarce. The aim of this study was to provide preliminary data on clinical and social benefits of adding Personal Health Budget to a standard pharmacotherapy in patients with severe mental illness across a 24-month follow-up period. Methods: Participants ( n = 137) were individuals with severe mental illness, aged 18–50 years, recruited in one of the adult mental health services of the Parma Department of Mental Health. They completed the Global Assessment of Functioning scale, the Health of the Nation Outcome Scale and the Brief Psychiatric Rating Scale. This age range was chosen to limit Personal Health Budget interventions to adults with a non-prolonged illness duration. Friedman’s test for repeated measure was used to assess the longitudinal stability of functioning and clinical parameters. A linear regression analysis was also performed. Results: A significant decrease in all Global Assessment of Functioning scale, Health of the Nation Outcome Scale and Brief Psychiatric Rating Scale scores along the 24 months of follow-up was observed. Regression analysis results specifically showed a relevant association between a Personal Health Budget multiaxial intervention and the longitudinal reduction in Brief Psychiatric Rating Scale ‘Negative Symptoms’ and Health of the Nation Outcome Scale ‘Social Problems’ subscores. Conclusion: Our findings support the useful implementation of a Health of the Nation Outcome Scale approach for severe mental illness patients within the Italian mental health service network.
Silver nanoparticle modified carbon fiber-reinforced polymer material for resistance against thermal damage induced by irradiation
Authors: Schuster Thomas J , Weller Lars , Wolfrum Johannes , Eibl Sebastian 
Published: October 2020

We investigated the resistance of carbon fiber-reinforced plastics (CFRP) to thermal radiation when silver nanoparticles are added to the resin. An epoxy based CFRP material filled with up to 10 wt.% silver nanoparticles, with respect to the polymer matrix, shows an increase in time to ignition of up to ∼ 30% when irradiated from one side with an electrical heater with heat fluxes of 35 and 80 kW/m2. Scattering and specular reflectance of infrared light was analyzed before thermal irradiation, showing enhanced scattering of samples with increasing silver particle content, which correlates linearly to the time to ignition. The reaction to fire properties of the CFRP, analyzed by cone calorimetry, are also influenced positively by the silver nanoparticles. The thermal conductivity, as measured by laser-flash-analysis, shows no influence by the nanoparticles. Therefore, the increase in time to ignition, as well as the more homogeneous combustion, are not due to changes in conductivity, but to scattering and reflection effects caused by the nanoparticles. The modified material shows no decline in interlaminar shear strength, representing structural properties. Health and environmental risks by nanoparticle release during production, combustion, and machining of the modified CFRP are also investigated. The preliminary results show no additional hazards.
Perceptions of Public Health Priorities and Accountability Among US Mayors
Authors: Godinez Puig Luisa , Lusk Katharine , Glick David , Einstein Katherine L. , Palmer Maxwell , Fox Stacy , Wang Monica L. 
Published: October 2020

Objective Mayors have considerable and often direct influence over health policy in their cities, yet little is known about mayors’ general perceptions of current public health challenges. The objective of this study was to assess perceptions, attitudes, and priorities related to public health among US mayors. Methods We collected survey data from a nationally representative sample of US mayors (N = 110) in 2018 and matched survey responses with city-level health surveillance data. We conducted descriptive analyses and multivariable regression modeling to estimate associations of interest. Results Mayors in our sample most frequently cited obesity/chronic diseases (23.6%; 26 of 110), opioid abuse/drug addiction (22.7%; 25 of 110), and health care access (13.6%; 15 of 110) as the top health challenges facing their cities. However, mayors identified a different set of health issues for which they believed constituents hold them accountable. With the exception of opioid-related deaths, prevalence of a health concern was not associated with perceived accountability for that particular issue, whereas partisanship and sex predicted patterns in perceived accountability. Conclusions Mayors recognized critical health challenges at the city level but varied widely in their perceived accountability for such challenges. Findings can inform strategies to engage local policy makers in cross-sector collaborations to improve the health and overall well-being of people in cities across the United States.
Lack of Serologic Evidence of Infection Among Health Care Personnel and Other Contacts of First 2 Confirmed Patients With COVID-19 in Illinois, 2020
Authors: McPherson Tristan D. , Ghinai Isaac , Binder Alison M. , Freeman Brandi D. , Hoskin Snelling Chantel , Hunter Jennifer C. , Anderson Kristin M. , Davenport Polly , Rudd Deborah L. , Zafer Mujeeb , Christiansen Demian , Joshi Kiran , Rubin Rachel , Black Stephanie R. , Fricchione Marielle J. , Pacilli Massimo , Walblay Kelly A. , Korpics Jacqueline , Moeller Darcie , Quartey-Kumapley Pearl , Wang Chen , Charles E. Matt , Kauerauf Judy , Patel Megan T. , Disari Vishal S. , Fischer Marc , Jacobs Max W. , Lester Sandra N. , Midgley Claire M. , Rasheed Mohammed Ata Ur , Reese Heather E. , Verani Jennifer R. , Wallace Megan , Watson John T. , Thornburg Natalie J. , Layden Jennifer E. , Kirking Hannah L. 
Published: October 2020

Objectives Widespread global transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19), continues. Many questions remain about asymptomatic or atypical infections and transmission dynamics. We used comprehensive contact tracing of the first 2 confirmed patients in Illinois with COVID-19 and serologic SARS-CoV-2 antibody testing to determine whether contacts had evidence of undetected COVID-19. Methods Contacts were eligible for serologic follow-up if previously tested for COVID-19 during an initial investigation or had greater-risk exposures. Contacts completed a standardized questionnaire during the initial investigation. We classified exposure risk as high, medium, or low based on interactions with 2 index patients and use of personal protective equipment (PPE). Serologic testing used a SARS-CoV-2 spike enzyme-linked immunosorbent assay on serum specimens collected from participants approximately 6 weeks after initial exposure to either index patient. The 2 index patients provided serum specimens throughout their illness. We collected data on demographic, exposure, and epidemiologic characteristics. Results Of 347 contacts, 110 were eligible for serologic follow-up; 59 (17% of all contacts) enrolled. Of these, 53 (90%) were health care personnel and 6 (10%) were community contacts. Seventeen (29%) reported high-risk exposures, 15 (25%) medium-risk, and 27 (46%) low-risk. No participant had evidence of SARS-CoV-2 antibodies. The 2 index patients had antibodies detected at dilutions >1:6400 within 4 weeks after symptom onset. Conclusions In serologic follow-up of the first 2 known patients in Illinois with COVID-19, we found no secondary transmission among tested contacts. Lack of seroconversion among these contacts adds to our understanding of conditions (ie, use of PPE) under which SARS-CoV-2 infections might not result in transmission and demonstrates that SARS-CoV-2 antibody testing is a useful tool to verify epidemiologic findings.
Comparison of diet quality among female students in different majors at Taibah University
Authors: Jalloun Rola A , Maneerattanasuporn Tiwaporn 
Published: October 2020

Background: Diet quality is a term used to assess both the quality and variety of food intake by comparing dietary guidelines. The quality of dietary intake can be used to determine the association between food intake and health status. Studies comparing diet quality among students from different departments are limited. Aim: The aim of this study was to determine the dietary quality of female college students with majors in different departments at Taibah University, Madinah, Kingdom of Saudi Arabia. Methods: This study was a cross-sectional study conducted with 658 female participants. The Diet Quality Index-International (DQI-I) was used to describe dietary quality. Results: The total DQI-I score of the College of Applied Medical Sciences (CAMS) students (55.5%) was higher than those of the College of Sciences (CS) (52.3%) and College of Arts and Humanities (CAH) (50.4%) students. The risk of having a poor diet was higher among the CS (odds ratio (OR) = 1.154, 95% confidence interval (CI) (95% CI) = 1.007–1.879) and CAH students (OR = 1.624, CI = 1.012–2.604) than among the CAMS students. Having a low DQI-I score was associated with a high risk of obesity (OR= 2.478, 95% CI = 1.007–3.879) and a high body fat % (OR = 3.920, 95% CI = 1.757–8.749). Conclusion: This study showed the need to raise awareness among the younger population about the importance of healthy eating, which involves implementing healthy habits to improve one’s quality of life.
Cytosorb® hemoadsorption of apixaban during emergent cardio-pulmonary bypass: a case report
Authors: Mendes Vitor , Colombier Sébastien , Verdy François , Bechtold Xavier , Schlaepfer Pierre , Scala Emmanuelle , Schneider Antoine , Kirsch Matthias 
Published: October 2020

Background: Peri-operative coagulation management of patients receiving apixaban, a new oral anticoagulant, is difficult. The CytoSorb® hemoadsorption device might represent a therapeutic option to reduce apixaban’s pharmacological and inflammatory effects during high-risk surgery. Case presentation: An 83-year-old woman treated with Apixaban underwent emergent redo mitral valve replacement for prosthetic valve endocarditis. A CytoSorb® cartridge was added to the cardio-pulmonary bypass (CPB) circuit. Apixaban-specific anti-factor Xa activity (AFXaA) were measured peri-operatively. After 100 minutes of CPB, a 50% AFXaA rate decrease was observed as compared to pre-CPB values. Furthermore, we noticed 39% and 44% reductions of AFXaA levels in comparison to the expected levels in patients with normal or altered renal function, respectively. Conclusion: Insertion of a CytoSorb® cartridge in the CPB was safe and associated with rapid correction of Apixaban-associated anticoagulation.
Potential interactions between pangenotypic direct-acting antivirals and concomitant cardiovascular therapies in patients with chronic hepatitis C virus infection
Authors: Sicras-Mainar Antoni , Morillo-Verdugo Ramón 
Published: October 2020

Objective To identify potential drug interactions (DIs) between pangenotypic direct-acting antivirals (pDAAs) and concomitant cardiovascular (CV) therapies in patients with chronic hepatitis C (CHC). Methods A retrospective observational study was carried out. Patients ≥18 years of age diagnosed with CHC and treated with pDAAs during 2017 were included. Information was collected on concomitant CV therapies and potential DIs [ www.hep-druginteractions.org ]. The pDAAs analyzed were sofosbuvir/velpatasvir (SOF/VEL), glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX). An analysis including lipid-lowering drugs was also performed. Results In total, 1286 patients (mean age 64.9 years, 56.6% men) were recruited. The percentages of potential DIs with CV drugs were 1.9% contraindications, 38.1% clinically significant and 2.4% weak. When lipid-lowering drugs were included, the percentages of potential DIs with CV drugs were 10.3% contraindications, 46.3% clinically significant and 3.2% weak. Potential DIs associated with each pDAA were as follows (contraindications; clinically significant; weak): SOF/VEL (1.4%; 23.0%; 0.9%), GLE/PIB (12.8%; 60.8%; 4.7%) and SOF/VEL/VOX (16.6%; 55.1%; 4.9%). Conclusions Approximately on third of patients with CHC are concomitantly treated with CV drugs. SOF/VEL may have fewer DIs with CV drugs than other pDAAs.
Management of ovarian cancer: guidelines of the Italian Medical Oncology Association (AIOM)
Authors: Gadducci Angiolo , Aletti Giovanni D. , Landoni Fabio , Lazzari Roberta , Mangili Giorgia , Olivas Paola , Pignata Sandro , Salutari Vanda , Sartori Enrico , Scambia Giovanni , Zannoni Gian Franco , Sabbatini Roberto , Lorusso Domenica 
Published: October 2020

Introduction: Ovarian cancer is the most lethal gynecologic malignancy. Over 5200 new cases of this tumor are diagnosed yearly in Italy, resulting in more than 3600 deaths. In terms of molecular biology, five different ovarian cancer subtypes should be distinguished. Method: This article summarizes the evidence-based guidelines that the Italian Medical Oncology Association (AIOM) has developed with a multidisciplinary panel of experts, including pathologists, gynecologic oncologists, medical oncologists, and radiotherapists, with the support of methodologists, to help clinicians involved in the management of patients with ovarian cancer in their daily clinical practice. Results: The most relevant randomized clinical trials regarding surgery, chemotherapy, and molecularly targeted agents (bevacizumab and PARP inhibitors) in early, advanced, and recurrent disease have been critically analyzed. The levels of evidence and strength of recommendation have been reported for any issue. Conclusion: Women with a clinical suspicion of ovarian cancer should be centralized in referral centers. The BRCA test should be requested for all women with nonmucinous and nonborderline tumors, regardless of age and family history. BRCA testing could be preferentially performed on neoplastic tissue. In the presence of a positive tumor test, a genetic test should always be performed on a blood sample to differentiate between germline mutations, which require counseling and genetic testing of family members, and somatic mutations.
Slope-Reducing Tibial Osteotomy Combined With Primary Anterior Cruciate Ligament Reconstruction Produces Improved Knee Stability in Patients With Steep Posterior Tibial Slope, Excessive Anterior Tibial Subluxation in Extension, and Chronic Meniscal Posterior Horn Tears
Authors: Song Guan-yang , Ni Qian-kun , Zheng Tong , Zhang Zhi-jun , Feng Hua , Zhang Hui 
Published: October 2020

Background: Steep posterior tibial slope (PTS; >13°), excessive anterior tibial subluxation (ATS) in extension (>10 mm), and meniscus posterior horn tears (MPHTs) have been identified to be associated with primary anterior cruciate ligament (ACL) reconstruction (ACLR) failure. Recent studies have reported that steep PTS is directly correlated with excessive ATS in extension and concomitant MPHTs, especially for those patients with chronic (>6 months) ACL deficiency. There is increasing biomechanical evidence that slope-reducing tibial osteotomy decreases ATS in extension and protects the ACL graft. Hypothesis: Slope-reducing tibial osteotomy combined with primary ACLR is effective for producing improved knee stability in patients with steep PTS (>13°), excessive ATS in extension (>10 mm), and concomitant chronic MPHTs (>6 months). Study Design: Case series; Level of evidence, 4. Methods: Between June 2016 and January 2018, 18 patients with ACL injuries who had steep PTS (>13°), excessive ATS in extension (>10 mm), and concomitant chronic MPHTs (>6 months) underwent slope-reducing tibial osteotomy combined with primary ACLR. The PTS and anterior subluxation of the lateral and medial compartment (ASLC and ASMC) in extension before and after the index procedures were regarded as primary clinical outcomes. Moreover, Lysholm score, Tegner activity score, International Knee Documentation Committee (IKDC) objective grade, pivot-shift test, and KT-1000 side-to-side difference were evaluated preoperatively and at the minimum 2-year follow-up visit. Results: The mean PTS was 18.5° (range, 17°-20°) preoperatively and 8.1° (range, 7°-9°) postoperatively ( P < .01). The mean ASLC and ASMC in extension were 12.1 mm and 11.9 mm preoperatively, which reduced to 1.0 mm and 1.5 mm at the last follow-up visit ( P < .05). In addition, all of the following showed significant improvements (pre- vs postoperatively): mean Lysholm score (46.5 vs 89.5; P < .05), mean Tegner activity score (5.7 vs 7.3; P < .05), IKDC objective grading results (18 grade D vs 14 grade A and 4 grade B; P < .05), pivot-shift tests (15 grade 2+ and 3 grade 3+ vs 18 grade 0; P < .01), and KT-1000 side-to-side difference (13.0 mm vs 1.6 mm; P < .01). Moreover, no graft reruptures were found at the final follow-up visit. Conclusion: In this study, slope-reducing tibial osteotomy combined with primary ACLR effectively improved knee stability in patients with steep PTS (>13°), excessive ATS in extension (>10 mm), and concomitant chronic MPHTs (>6 months).
Differences in Clinical Presentations and Surgical Outcomes of Gluteus Medius Tears Between Men and Women
Authors: Meghpara Mitchell B. , Bheem Rishika , Haden Marshall , Rosinsky Philip J. , Shapira Jacob , Maldonado David R. , Lall Ajay C. , Domb Benjamin G. 
Published: October 2020

Background: Gluteus medius (GM) tears often occur in women aged >50 years. There is a paucity of literature comparing sex-based differences in those undergoing GM repair. Purpose: To report differences between women and men in clinical presentations and patient-reported outcome (PRO) scores at a minimum 2-year follow-up after undergoing GM repair. Study Design: Cohort study; Level of evidence, 3. Methods: Data were prospectively collected and retrospectively reviewed. All included patients had postoperative scores for the following PROs: modified Harris Hip Score (mHHS), Non-arthritic Hip Score (NAHS), Hip Outcome Score–Sports Specific Subscale (HOS-SSS), and International Hip Outcome Tool–12. Men were propensity score matched 1:3 to women according to concomitant arthroscopic procedures and follow-up time. Clinical effectiveness was determined through a uniquely calculated minimal clinically important difference (MCID) for the mHHS and NAHS specific to this study population. Results: Thirteen men were successfully propensity score matched to 39 women. Women and men were 55.87 ± 11.0 and 62.38 ± 11.63 years old (mean ± SD), respectively ( P = .02). Men were at increased risk for associated lumbar pathology as compared with women (relative risk, 3.32; P = .02). Women showed significant improvement from preoperative to minimum 2-year follow-up for the mHHS (59.32 ± 15.36 to 83.81 ± 16.82; P < .01), NAHS (56.23 ± 15.61 to 83.78 ± 17.66; P < .01), HOS-SSS (33.35 ± 20.28 to 67.88 ± 32.35; P < .01), and visual analog scale (5.48 ± 2.00 to 1.93 ± 2.29; P < .01). Similarly, men showed significant improvement for the mHHS (63.50 ± 16.41 to 84.77 ± 13.91; P < .01), NAHS (61.52 ± 9.87 to 84.42 ± 14.87; P < .01), HOS-SSS (33.97 ± 21.20 to 63.62 ± 26.20; P < .01), and visual analog scale (4.93 ± 2.69 to 1.86 ± 2.10; P < .01). The MCIDs for the mHHS and NAHS were calculated to be 7.89 and 7.24. Of the women, 28 (72%) and 34 (87%) met the MCID for the mHHS and NAHS. Eleven (85%) men met the MCID for the mHHS and NAHS. Conclusion: These results suggest that women and men can both benefit after GM repair. Men were older and had increased risk for associated lumbar pathology than women at the time of surgery. Men and women both experienced significant improvements in PROs and compared favorably in terms of clinical effectiveness at a minimum 2-year follow-up.