bluuebunny/crossref_metadata_2025_split huggingface dataset:
NELARABINE TREATMENT IN ADULT PATIENTS WITH REFRACTORY/ RELAPSED T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA/LYMPHOMA: EXPERIENCE OF A SINGLE CENTRE
Authors: Gavrilina O. A. , Kotova E. S. , Parovichnikova E. N. , Troitskaya V. V. , Sokolov A. N. , Baskhaeva G. A. , Zarubina K. I. , Fidarova Z. T. , Kuzmina L. A. , Dvirnyk V. N. , Obukhova T. N. , Savchenko V. G. 
Published: December 2019

Introduction.Modern therapy for relapses and resistant forms of T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL/ LBL) shows poor efficacy. The use of nelarabine can improve the results of therapy in patients with refractory/relapsed T-ALL/LBL.Aim.To evaluate the efficacy and toxicity of nelarabine treatment combined with etoposide and cyclophosphamide in adult patients with refractory/relapsed T-ALL/LBL.Materials and methods. During the 2012–2018 period, 10 patients with refractory/relapsed T-ALL aged from 19 to 41 underwent nelarabine treatment. The patients received from 1 to 3 chemotherapy courses including nelarabine 650 mg/m2 (days 1 to 5), etoposide 100 mg/m2 and cyclophosphamide 440 mg/m2 (days 8 to 12). All the patients having achieved complete remission (СR) underwent transplantation of allogeneic haematopoietic stem cells (allo-HSCT). The development of toxic sequelae (myelosuppression, neurotoxicity, incidence of infectious complications) was considered after each chemotherapy course.Results. Out of 10 patients who received 1–2 chemotherapy courses, 6 (60 %) achieved CR. These 6 patients subsequently underwent allo-HSCT, which was followed by early relapse in 3 (50 %) of 6 patients and the death of 1 patient in persisting CR caused by infectious complications. Only 2 of 6 patients have been monitored for 1.5 years after the allo-HSCT. The five-year overall survival rate in relapsed patients came to 18 %. In terms of toxic sequelae, myelosuppression and infectious complications were observed in all patients. Neurotoxicity was noted in 3 (30 %) out of 10 patients, with two of them experiencing it after each course and one patient — only following the third course of nelarabine treatment.Conclusion. The use of nelarabine for the treatment of refractory/relapsed T-ALL/LBL provides the opportunity to achieve CR in 60 % of cases, as well as to perform allo-HSCT. However, long-term results are not very optimistic, thus further research is required.Conflict of interest:the authors declare no conflict of interest.Financial disclosure:the study had no sponsorship.
METALLOPROTEASE ADAMTS-13
Authors: Koloskov A. V. , Mangushlo A. A. 
Published: December 2019

Introduction. The signifi cance of ADAMTS-13 extends beyond its key role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP); there is evidence of a relationship between a decrease in the ADAMTS-13 activity and thrombotic events in acute myocardial infarction and ischemic stroke.Aim. To generalise available information on the structure and function of the metalloprotease ADAMTS-13.General findings. The biological function of ADAMTS-13 consists in the cleavage of ultra-large von Willebrand factor (vWF) multimers. The fact that its defi ciency causes the development of TTP provides a basis for understanding the function of vWF–cleaving protease. ADAMTS-13 has a domain structure. The functional roles of most ADAMTS-13 domains, as well as the key role of the ADAMTS-13-vWF interaction in the regulation of haemostasis, are defi ned. The conformational activation of ADAMTS-13 by vWF constitutes an important aspect of its function. After getting into the bloodstream, ultra-large vWF multimers quickly adopt a closed conformation, which becomes very resistant to ADAMTS-13 proteolysis in the absence of shear stress. Ultra-large plasma vWF multimers regain their sensitivity to ADAMTS-13 after being exposed to high fl uid shear stress, which unfolds the central vWF-A2 domain. The unfolding of a vWF molecule under shear stress conditions reveals previously hidden exosites in domain A2, which gradually increase the binding affi nity between ADAMTS-13 and vWF. The mechanism underlying the production of autoantibodies against ADAMTS-13 is unknown and requires further study. The masking of cryptic epitopes in the closed conformation of ADAMTS-13 prevents the formation of autoantibodies. Early antigen recognition of ADAMTS-13 occurs through surface-exposed epitopes in the C-terminal domains. More detailed information on the mechanisms underlying the interaction between ADAMTS-13 and the vWF can improve the understanding of mechanisms involved in the regulation of the coagulation system.Conflict of interest: the authors declare no confl ict of interest.Financial disclosure: the study had no sponsorship.
CASE OF ATYPICAL WARFARIN-INDUCED SKIN NECROSIS IN A CHILD WITH CONGENITAL HEART DISEASE
Authors: Lastovka V. A. , Tepaev R. F. , Gordeeva O. B. , Gandaeva L. A. , Basargina E. N. , Derevnina Yu. V. , Penkov Ye. L. 
Published: December 2019

Introduction. Warfarin-induced skin necrosis constitutes a rare complication of warfarin treatment.Aim. To present a case study of the occurrence and successful treatment of atypical warfarin-induced skin necrosis in a child with congenital heart disease.General findings. The development of finger skin necrosis in a child with congenital heart disease almost 2 years after the start of warfarin therapy was described. In addition, possible causes of the complication and methods for its treatment were discussed.Conflict of interest: the authors declare no conflict of interest.Financial disclosure: the study had no sponsorship
CONGENITAL FACTOR V DEFICIENCY: CASE REPORTS
Authors: Yakovleva E. V. , Konyashina N. I. , Gorgidze L. A. , Surin V. L. , Pshenichnikova O. S. , Polevodova O. A. , Spirin M. V. , Galstyan G. M. , Zozulya N. I. 
Published: December 2019

Introduction. Haemophilia and von Willebrand disease constitute the most common hereditary coagulopathies. However, such rare hereditary coagulopathies as congenital factor V defi ciency can mistakingly be referred to these diseases.Aim. To describe the clinical manifestations and treatment of congenital factor V defi ciency.General findings. The article presents a literature review, as well as three case studies of patients with congenital factor V deficiency. Given that the choice of haemostatic therapy depends on accurate diagnosis, issues associated with the differential diagnosis of hereditary coagulopathies are considered as well. Patients with congenital factor V deficiency require continuous monitoring by a haematologist in order to control spontaneous or induced haemorrhagic syndrome, as well as to plan haemostatic therapy in case of surgical procedures, pregnancy or childbirth.Conflict of interest: the authors declare no conflict of interest.Financial disclosure: the study had no sponsorship.
Escasa presencia de la mujer enfermera en
puestos de poder
Authors: Méndez-Salguero Alicia , García-Garcí José Eloy 
Published: December 2019

Introduction: It's a fact that nursing is a profession where most of their components are women, nevertheless, responsibility and decision-making positions aremainly occupied bymale nurses, and this is like this in spite of that they only represent 16 % of the professional contingent. The tokenism explains well this reality.
Objectives: To value if the female nurse suffers discrimination inside the own profession, in the nurses' union and in the professional association. To verify if in the responsibility positions inside the Regional Health Services, the nurse is still relegated to other health professionals or not.
Methodology: Bibliography researches weremadein various databases using the keywords and selecting with the ten years filter articles in Spanish and English, and official databases were revised (INE, EPA, CGE, SATSE and websites of the Regional Health Services).
Results: The 84 % of the professionals nurses are females, although in the 15 Regional Nurses Councils consulted, there are only 5 chairwomen. In the SATSE, 58 %of secretariats are occupied bywomen, percentage that is not appropriate with the gender distribution in this collective. It is also alleged that nurses are not present as managers of Health Services.
Discussion: It has been shown that nursing, despite being a feminized profession, has to deal with the phenomenon of the token in their ownworld somen dominate positions of power as evidenced by the data.
Conclusions:The female nurse is still in an inferior position both inside and outside the profession.
Keywords: nurse, tokenism, glass escalator, feminization.
TANTANGAN DALAM PENCIPTAAN SENI RUPA TRADISI DI ERA REVOLUSI INDUSTRI 4.0
Authors: . Karsam 
Published: December 2019

The industrial revolution 4.0 was an era where all aspects were made, carried out, carried out with tools and facilities that were all modern including the creation of traditional art. The order of human behavior in work that cannot keep up with changes in the digital age will be marginalized. This condition can marginalize and even destroy the existence of traditional art.This research was carried out by using qualitative method in which data are obained from observation, literature review and direct practice in the field, where the author is the actor of the creation of traditional art.The purpose of this study is to preserve and preserve the existence of traditional fine art on this earth, so the creators (Artists, Masters, Kriyawan, Craftsmen, etc.) must be able to use media, tools, materials, facilities that develop in this time. The author hopes that this research can benefit readers, researchers, reviewers and traditional art actors to continue working in this era of industrial revolution 4.0 without abandoning traditional artistic values.
ANALISIS DETERMINAN YANG MEMPENGARUHI KEPATUHAN IBU TENTANG PEMBERIAN IMUNISASI MEASLES RUBELA PADA BALITA DI PUSKESMAS DELI TUA KABUPATEN DELI SERDANG
Authors: NATALIA KRISTIN 
Published: December 2019

The purpose of this study was to analyze what determinants influence maternal adherence regarding Measles Rubella immunization in infants. This type of research is quantitative research with cross sectional study design. The population in this study were all mothers who have children under five in the Delitua Health Center with asample size of 36 people. Data collection methods obtained directly from respondents through interviews using interview guidelines (questionnaire). Secondary data were obtained from Obstetric Gynecology records in the midwifery room and the medical records of the Deli Tua Health Center. Data retrieval of information will be done by interviewing Delitua Health Center with a questionnaire that has fulfilled the elements of validity and reliability. The results of this study are factors that greatly affect mothers not giving MR immunization in infants is a factor of family support with a value of 1.397 and information source factors. It is expected that health workers will provide more health information to the public that MR immunization is very important for toddlers to prevent Measles Rubella disease.
Un forastero literario y sus crímenes norteños
Authors: Ramírez Pimienta Juan Carlos 
Published: December 2019

Francisco José Amparán, uno de los más importantes escritores de la narrativa policíaca mexicana, nació en Torreón, Coahuila, en 1957. Ha publicado: La luna y otros testigos (1984), Los once y sereno (1985), Las noches de Walpurgis (y otras ondas) (1986), Cantos de acción a distancia (1988), Es otra la felicidad (1990), todos ellos volúmenes de cuentos, así como Algunos crímenes norteños (noveletas, 1991), Otras caras del paraíso (novela, 1994), Tríptico gótico (cuento, 1996) y Cómo ganéla guerra (novela corta, 1999). Ha obtenido algunos de los más prestigiados premios literarios, entre ellos el Latinoamericano de Cuento (1983) y el Nacional de Literatura (Cuento) (1986). A pesar de los anteriores logros, Amparán continua siendo, en buena medida, un forastero para el establishment literario. En esta entrevista, realizada en julio del 2002, el autor nos habla de su relación con la literatura policiaca.
Volek, Emil. Latin America Writes Back: Postmodernity in the Periphery (An interdisciplinary cultural perspective)
Authors: Plancarte Martínez María Rita 
Published: December 2019

La cuestión de la posmodernidad en sus dimensiones filosóficas, estéticas, sociales y demás, resultante de los vertiginosos cambiosculturales vividos a partir los años sesenta, ha sido abordada ampliamente por la academia europea y estadounidense. En el medio intelectual anglohablante es poco lo que se conoce sobre las formas de reconocer y pensar la posmodernidad desde América Latina, por lo que el libro editado por Emil Volek viene a hacer presente en esa esfera un conjunto representativo de ensayos, producto de la reflexión que en lo relativo a esta temática se han venido dando en el continente.
HUBUNGAN BEBAN KERJA DAN EFIKASI DIRI DENGAN BURNOUT PADA ANGGOTA SATUAN BRIGADE MOBILE KEPOLISIAN DAERAH SUMATERA UTARA
Authors: Fahruroddin  
Published: December 2019

This study aims to determine the relationship between workload and self-efficacy with burnout. The study was conducted at the mobile brigade police of the Republic of Indonesia North Sumatra. The number of respondents in this study were 196 members of the mobile brigade with non probability sampling techniques. Based on Spearman rank data analysis obtained a significant level between workload with burnout with a significant value of 0,000 <0,05, meaning that there is a partial relationship between workload and burnout. While the relationship of self-efficacy with burnout with a significant value of 0,000 <0.05. This proves that there is a partial relationship between self efficacy and burnout. While the significance level of the workload and self efficacy with burnout with a significant value of 0,000 <0,05 are related simultaneously, then the hypothesis in this study is accepted. The correlation between workload and self efficacy with burnout on members of the mobile brigade, North Sumatra is 90%. The conclusions of this research are workload and self efficacy have relationship significant with burnout. Keywords: Burnout, workload, self-efficacy.

Penelitian ini bertujuan untuk mengetahui hubungan beban kerja dan efikasi diri dengan burnout. Penelitian dilaksanakan di satuan brigade mobile kepolisian daerah Sumatera Utara. Jumlah responden dalam penelitian ini adalah 196 anggota satuan brigade mobile dengan teknik pengambilan sampel non probability sampling. Berdasarkan analisis data rank spearman diperoleh taraf signifikan antara beban kerja dengan burnout dengan nilai signifikan 0,000 < 0,05, artinya membuktikan bahwa terdapat hubungan secara parsial beban kerja dengan burnout. Sedangkan hubungan efikasi diri dengan burnout dengan nilai signifikan 0,000 < 0,05. Hal tersebut membuktikan bahwa terdapat hubungan secara parsial konsep diri dengan burnout. Sedangkan taraf signifikasi beban kerja dan efikasi diri dengan burnout dengan nilai signifikan 0,000 < 0,05 berhubungan secara simultan, maka hipotesis dalam penelitian ini diterima. Besar korelasi hubungan beban kerja dan efikasi diri dengan burnout pada anggota satuan brigade mobile kepolisian daerah Sumatera Utara sebesar 0.90%. Kesimpulan penelitian ini adalah beban kerja dan efikasi diri berhubungan signifikan dengan burnout.
Kata Kunci: Burnout, beban kerja, efikasi diri.
ПРАВОВЫЕ ОСНОВЫ ЗЕЛЕНЫХ ПОЯСОВ ПРИГРАНИЧНЫХ ТЕРРИТОРИЙ
Authors: Olenina T. 
Published: December 2019

В работе рассматривается основные правовые проблемы в связи с введением лесопарковых зеленых поясов в российском законодательстве. Идея создания зеленых поясов очень хорошая и назрела давно необходимость в этом, но практическое воплощение в жизнь требует времени, совершенствования правовых норм, отработанного механизма их исполнения, профилактики правонарушений и другого. Интересен опыт Канады по созданию лесопарковых зеленых поясов, например в Оттаве, но для России не все подходит.
The paper considers the major legal problems in connection with the introduction of forest green belts in the Russian legislation. The idea of creating green belts is very good and this is long overdue, but practical implementation requires time, improvement of the legal norms, the exhaust mechanism for their enforcement, prevention and other. Interesting experience of Canada on the establishment of a park, such as green belts in Ottawa, but Russia is not everything fits.
«ТОЧКИ РОСТА» МЕЖДУНАРОДНОЙ МЕЖРЕГИОНАЛЬНОЙ ИНТЕГРАЦИИ НА ПРИМЕРЕ САМАРСКОЙ ОБЛАСТИ
Authors: Khmeleva G. 
Published: December 2019

На основе сопоставления экспортноимпортных операций, SWOTанализа предложены три ключевых направления ( точки роста ) развития международной экономической интеграции Самарской области: нефтехимия, агропромышленный сектор, туризм и создание крупного туристического кластера.
Based on a comparison of exportimport operations and SWOTanalysis, three key directions (growth points) for the development of international economic integration Samara region are proposed: petrochemicals, the agroindustrial sector, tourism, and the creation of a large tourist cluster.
ИССЛЕДОВАНИЕ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО ПОТЕНЦИАЛА СУБЪЕКТОВ И МУНИЦИПАЛЬНЫХ ОБРАЗОВАНИЙ СЕВЕРО-ЗАПАДНОГО ФЕДЕРАЛЬНОГО ОКРУГА (В КОНТЕКСТЕ РЕАЛИЗАЦИИ СТРАТЕГИЙ ПРОСТРАНСТВЕННОГО РАЗВИТИЯ)
Authors: Gerasimova I. , Gerasimova E. 
Published: December 2019

Различия в экономическом развитии российских территорий определяют межрегиональное неравенство в качестве жизни и благосостоянии населения. Они фиксируются официальными статистическими данными о социальноэкономическом положении на трех уровнях территориального деления и управления: 1) федеральные округа 2) субъекты федерации 3) муниципальные образования (МО). Актуально изучение взаимовлияния процессов социально экономического развития на этих уровнях. В статье основное внимание уделяется социально экономическому положению муниципалитетов. Дано краткое описание информационного обеспечения исследования. Представлен опыт сравнительного анализа трансграничных МО на примере субъектов СевероЗападного ФО.
Differences in the economic development of the Russian territories determine interregional inequality in the quality of life and wellbeing of the population. They are recorded by official statistics on the socioeconomic situation at three levels of territorial division and governance: 1) federal districts 2) subjects of the federation 3) municipalities (MO). The study of the mutual influence of the processes of socioeconomic development at these levels is relevant. The article focuses on the socioeconomic situation of municipalities. A brief description of the research information support is given. The experience of a comparative analysis of crossborder MOs on the example of subjects of the NorthWest Federal District is presented.
ГЕОГРАФИЯ СЕЛЬСКОГО ХОЗЯЙСТВА КУРСКОГО ПРИГРАНИЧЬЯ
Authors: Trebushkova I. 
Published: December 2019

В статье рассмотрены основные направления развития сельского хозяйства приграничной Курской области. Произведен анализ наиболее развитой и перспективной отрасли сельского хозяйства растениеводческой, имеющей выгодные природные, экономические, социальные условия для её развития.
The article considers the main directions of agricultural development in the border region of Kursk. The analysis of the most developed and promising sector of agriculture cropp production, which has favorable natural, economic, social conditions for its development.
«ИМАЖИНАЛЬНОСТЬ» ПОГРАНИЧЬЯ ВОРОНЕЖСКОЙ ОБЛАСТИ
Authors: Proskurina N. 
Published: December 2019

В статье рассматриваются географические образы , характерные одному из приграничных регионов России Воронежской области. Раскрыты особенности их формирования и влияния на развитие региона.
The article deals with the geographical images characteristic of one of the border regions of Russia the Voronezh region. The features of their formation and influence on the development of the region are revealed.
АКТУАЛЬНЫЕ ПРОБЛЕМЫ СОВЕРШЕНСТВОВАНИЯ РЕГИОНАЛЬНОЙ СТАТИСТИКИ В УСЛОВИЯХ ЦИФРОВИЗАЦИИ ЭКОНОМИКИ (НА ПРИМЕРЕ РЕСПУБЛИКИ КАРЕЛИЯ)
Authors: Godoeva Z. 
Published: December 2019

В статье дано определение региональной статистики, сформулированы ее цели и задачи. Рассмотрены актуальные проблемы совершенствования региональной статистики в условиях цифровизации экономики. Приведены результаты анализа готовности населения и бизнеса Республики Карелия к цифровой экономике.
The article defines regional statistics and formulates its goals and objectives. Actual problems of improving regional statistics in the context of digitalization of the economy are considered. The results of the analysis of the readiness of the population and business of the Republic of Karelia to the digital economy are presented.
ВЛИЯНИЕ ПОВЫШЕНИЯ ПЕНСИОННОГО ВОЗРАСТА НА ЧИСЛЕННОСТЬ НАСЕЛЕНИЯ ТРУДОСПОСОБНОГО ВОЗРАСТА
Authors: Skufina T. , Baranov S. 
Published: December 2019

Приведена постановка проблемы и значимость оценки влияния повышения пенсионного возраста на основные макроэкономические показатели. Рассмотрено влияние повышения пенсионного возраста на численность трудоспособного населения Российской Федерации. Анализ реальных данных и трех вариантов прогноза численности трудоспособного населения до 2036 г. указал на устойчивый спад численности трудоспособного населения, наблюдаемый с 2006 г. Приведены оценки авторов, указывающие, что повышение возраста выхода на пенсию приостановил устойчивую тенденцию снижения численности трудоспособного населения в России. Ключевые слова: пенсионная реформа, трудоспособное население, ВВП, производственные функции, прогноз.
The article presents the problem and the importance of assessing the impact of raising the retirement age on the main macroeconomic indicators. The influence of increasing the retirement age on the number of ablebodied population of the Russian Federation is considered. Analysis of real data and three variants of the workingage population forecast up to 2036 pointed to a steady decline in the working age population observed since 2006. The authors estimates indicate that the increase in the retirement age has suspended the steady decline in the number of workingage population in Russia. Key words: pension reform, ablebodied population, GDP, production functions, forecast.
ПРИГРАНИЧНЫЙ ПОЯС КАК ГЕОСТРАТЕГИЧЕСКАЯ ТЕРРИТОРИЯ РОССИИ
Authors: Tolstoguzov O. 
Published: December 2019

В сообщении представлен приграничный пояс России как геостратегический объект. Приведены результаты анализ проблем и обозначены приоритеты при разработке стратегии развития геостратегического объекта, развивающегося в пространственновременной размерности регионального комплексообразования на евразийском континенте.
The report presents the border zone of Russia as a geostrategic object. The results of the analysis of problems and priorities in the development of the strategy of geostrategic object developing in the spatial and temporal dimension of regional complex formation on the Eurasian continent are presented.
НУЖНА ЛИ ОСОБАЯ ЭКОНОМИЧЕСКАЯ ЗОНА В КАРЕЛИИ?
Authors: Arnautova L. , Gladkikh E. 
Published: December 2019

Статья посвящена рассмотрению вопроса о необходимости создания особой экономической зоны в республике Карелия. Авторы рассматривают цели создания, анализируют созданные в Тульской и Псковской областях особые экономические зоны, которые были выбраны в качестве примеров для создания подобной зоны в Карелии. Особое внимание уделяется рассмотрению размещения данной зоны в поселке Вяртсиля.
This article is devoted to the issue of the need to create a special economic zone in the Republic of Karelia as a border zone. The reasons and goals of creation, alternative accommodation were considered, the special economic zones created in Tula and Pskov regions are studied, which were considered as an example for its creation in Karelia. The sources of financing and payback, the costs associated with the creation of the SEZ and whether they were taken into account when creating it in Vyartsilya are considered. Particular attention is paid to the consideration of the location of this zone in the village of Vyartsilya.