bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model
Authors: Suurs Frans V. , Qiu Si-Qi , Yim Joshua J. , Schröder Carolien P. , Timmer-Bosscha Hetty , Bensen Eric S. , Santini John T. , de Vries Elisabeth G. E. , Bogyo Matthew , van Dam Gooitzen M. 
Published: September 2020

Abstract
Purpose
The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative surgical margin assessment and to reduce reoperation rates. Cysteine cathepsins are overexpressed in most solid tumor types, including breast cancer. We developed a cathepsin-targeted, quenched fluorescent activity-based probe, VGT-309, and evaluated whether it could be used for tumor detection and image-guided surgery in syngeneic tumor-bearing mice.

Methods
Binding specificity of the developed probe was evaluated in vitro. Next, fluorescent imaging in BALB/c mice bearing a murine breast tumor was performed at different time points after VGT-309 administration. Biodistribution of VGT-309 after 24 h in tumor-bearing mice was compared to control mice. Image-guided surgery was performed at multiple time points tumors with different clinical fluorescent camera systems and followed by ex vivo analysis.

Results
The probe was specifically activated by cathepsins X, B/L, and S. Fluorescent imaging revealed an increased tumor-to-background contrast over time up to 15.1 24 h post probe injection. In addition, VGT-309 delineated tumor tissue during image-guided surgery with different optical fluorescent imaging camera systems.

Conclusion
These results indicate that optical fluorescent molecular imaging using the cathepsin-targeted probe, VGT-309, may improve intraoperative tumor detection, which could translate to more complete tumor resection when coupled with commercially available surgical tools and techniques.
[18F]MPPF and [18F]FDG μPET imaging in rats: impact of transport and restraint stress
Authors: Buchecker Verena , Waldron Ann-Marie , van Dijk R. Maarten , Koska Ines , Brendel Matthias , von Ungern-Sternberg Barbara , Lindner Simon , Gildehaus Franz Josef , Ziegler Sibylle , Bartenstein Peter , Potschka Heidrun 
Published: September 2020

Abstract
Background
Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alterations in 5-HT1A receptor binding following stress exposure. Considering the possible role of 5-HT1A receptors in stress coping mechanisms, respective imaging approaches are of particular interest.

Material and methods
For twelve consecutive days, Sprague Dawley rats were exposed to daily transport with a 1 h stay in a laboratory or daily transport plus 1 h restraint in a narrow tube. Following, animals were subjected to μPET imaging with 2′-methoxyphenyl-(N-2′-pyridinyl)-p-[18F]fluoro-benzamidoethylpiperazine ([18F]MPPF) and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). Behavioral and biochemical parameters were analyzed to obtain additional information.

Results
In rats with repeated transport, hippocampal [18F]MPPF binding exceeded that in the naive group, while no difference in [18F]FDG uptake was detected between the groups. A transient decline in body weight was observed in rats with transport or combined transport and restraint. Thereby, body weight development correlated with [18F]MPPF binding.

Conclusions
Mild-to-moderate stress associated with daily transport and exposure to a laboratory environment can trigger significant alterations in hippocampal binding of the 5-HT1A receptor ligand [18F]MPPF. This finding indicates that utmost care is necessary to control and report transport and associated handling procedures for animals used in μPET studies analyzing the serotonergic system in order to enhance the robustness of conclusions and allow replicability of findings. In view of earlier studies indicating that an increase in hippocampal 5-HT1A receptor expression may be associated with a resilience to stress, it would be of interest to further evaluate 5-HT1A receptor imaging approaches as a candidate biomarker for the vulnerability to stress.
Decitabine bioproduction using a biocatalyst with improved stability by adding nanocomposites
Authors: Méndez Mariana B. , Trelles Jorge A. , Rivero Cintia W. 
Published: September 2020

AbstractA novel IDA-LaNDT derivative was able to reach the highest productivity in the biosynthesis of a well-known antitumoral agent called decitabine. However, the combination of two simple and inexpensive techniques such as ionic absorption and gel entrapment with the incorporation of a bionanocomposite such as bentonite significantly improved the stability of this biocatalyst. These modifications allowed the enhancement of storage stability (for at least 18 months), reusability (400 h of successive batches without significant loss of its initial activity), and thermal and solvent stability with respect to the non-entrapped derivative. Moreover, reaction conditions were optimized by increasing the solubility of 5-aza by dilution with dimethylsulfoxide. Therefore, a scale-up of the bioprocess was assayed using the developed biocatalyst, obtaining 221 mg/L·h of DAC. Finally, green parameters were calculated using the nanostabilized biocatalyst, whose results indicated that it was able to biosynthesize DAC by a smooth, cheap, and environmentally friendly methodology.
Decentralized computation offloading for multi-user mobile edge computing: a deep reinforcement learning approach
Authors: Chen Zhao , Wang Xiaodong 
Published: September 2020

AbstractMobile edge computing (MEC) emerges recently as a promising solution to relieve resource-limited mobile devices from computation-intensive tasks, which enables devices to offload workloads to nearby MEC servers and improve the quality of computation experience. In this paper, an MEC enabled multi-user multi-input multi-output (MIMO) system with stochastic wireless channels and task arrivals is considered. In order to minimize long-term average computation cost in terms of power consumption and buffering delay at each user, a deep reinforcement learning (DRL)-based dynamic computation offloading strategy is investigated to build a scalable system with limited feedback. Specifically, a continuous action space-based DRL approach named deep deterministic policy gradient (DDPG) is adopted to learn decentralized computation offloading policies at all users respectively, where local execution and task offloading powers will be adaptively allocated according to each user’s local observation. Numerical results demonstrate that the proposed DDPG-based strategy can help each user learn an efficient dynamic offloading policy and also verify the superiority of its continuous power allocation capability to policies learned by conventional discrete action space-based reinforcement learning approaches like deep Q-network (DQN) as well as some other greedy strategies with reduced computation cost. Besides, power-delay tradeoff for computation offloading is also analyzed for both the DDPG-based and DQN-based strategies.
Fourier expansion and integral representation generalized Apostol-type Frobenius–Euler polynomials
Authors: Urieles Alejandro , Ramírez William , Ortega María José , Bedoya Daniel 
Published: September 2020

AbstractThe main purpose of this paper is to investigate the Fourier series representation of the generalized Apostol-type Frobenius–Euler polynomials, and using the above-mentioned series we find its integral representation. At the same time applying the Fourier series representation of the Apostol Frobenius–Genocchi and Apostol Genocchi polynomials, we obtain its integral representation. Furthermore, using the Hurwitz–Lerch zeta function we introduce the formula in rational arguments of the generalized Apostol-type Frobenius–Euler polynomials in terms of the Hurwitz zeta function. Finally, we show the representation of rational arguments of the Apostol Frobenius Euler polynomials and the Apostol Frobenius–Genocchi polynomials.
Influence of severity of infection on the effect of appropriate antimicrobial therapy for Acinetobacter baumannii bacteremic pneumonia
Authors: Kang Fang-Yu , How Chorng-Kuang , Wang Yung-Chih , Cheng Aristine , Yang Ya-Sung , Kuo Shu-Chen , Liu Chang-Pan , Liu Yuag-Meng , Chen Te-Li , Lee Yi-Tzu 
Published: September 2020

Abstract
Background
The impact of appropriate antimicrobial therapy for A. baumannii bacteremic pneumonia has not been well established due to the inclusion of the three phenotypically indistinguishable Acinetobacter species and confounding factors including underlying diseases and severity of infection. This retrospective study aimed to evaluate the impact of appropriate antimicrobial therapy on 14-day mortality in A. baumannii bacteremic pneumonia patients after adjusting for risk factors.

Methods
This study was conducted at five medical centers in Taiwan between July 2012 and June 2016. A. baumannii species identification was performed using reference molecular methods. Risk factors for 14-day mortality were analyzed via logistic regression. The interaction between the Acute Physiology and Chronic Health Evaluation (APACHE) II score and appropriate antimicrobial therapy was assessed using the logistic model.

Results
A total of 336 patients with monomicrobial A. baumannii bacteremic pneumonia were included in this study. The overall 14-day mortality rate was 47.3%. The crude mortality of appropriate antimicrobial therapy was 35.9% (57 of 151 patients). Appropriate antimicrobial therapy was associated with a lower mortality after multivariate adjustment (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.34–0.97; p = 0.04), and the effect was influenced by APACHE II score (OR for interaction term, 0.0098; 95% CI, 0.0005–0.1885; p = 0.002). Further analysis demonstrated that appropriate antimicrobial therapy significantly reduced 14-day mortality among the patients with an APACHE II score > 35 (OR 0.0098; 95% CI 0.0005–0.1885).

Conclusion
Appropriate antimicrobial therapy decreases 14-day mortality of the most severely ill patients with A. baumannii bacteremic pneumonia.
Finite Element Analysis and Calculation Method of Residual Flexural Capacity of Post-fire RC Beams
Authors: Cai Bin , Li Bo , Fu Feng 
Published: September 2020

AbstractFire tests and subsequent bending tests of four reinforced concrete (RC) beams were performed. Based on these tests, the post-fire performance of RC beams was further studied using finite-element simulation through reasonable selection of suitable thermal and thermodynamic parameters of steel and concrete materials. A thermodynamic model of RC beams with three sides under fire was built using finite-element analysis (FEA) software ABAQUS. The FEA model was validated with the results of fire tests. Different factors were taken into account for further parametric studies in fire using the propsed FE model. The results show that the main factors affecting the fire resistance of the beams are the thickness of the concrete cover, reinforcement ratio of longitudinal steel, the fire exposure time and the fire exposure sides. Based on the strength reduction formula at high temperature of steel and concrete and four test results, an improved section method was proposed to develop a calculation formula to calculate the flexural capacity of RC beams after fire. The theoretical calculation method proposed in this paper shows good agreement with FEA results, which can be used to calculate the flexural capacity of RC beams after fire.
The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017
Authors: Bai Xianguang , Yi Ming , Dong Bing , Zheng Xinhua , Wu Kongming 
Published: September 2020

Abstract
Background
Kidney cancer’s incidence and mortality vary in different regions and countries. To compare and interpret kidney cancer’s burden and change trends in the globe and in different countries, we conducted this study to report the global kidney cancer burden and attributable risk factors.

Methods
Data about kidney cancer’s incidence, death, disability-adjusted life-year (DALY) were extracted from the Global Burden of Diseases 2017. Besides, social-demographic index (SDI) values were adopted to investigate the correlation between kidney cancer’s burden and social development degrees.

Results
In the globe, the incidence case of kidney cancer increased sharply from 207.31*103 in 1990 to 393.04*103 in 2017. High SDI countries had the highest kidney cancer’s burden with a decreased trend in incidence rate. On the contrary, the incidence rate was rapidly increased in low-middle SDI countries, although their burden of kidney cancer kept relatively low. At the same time, the deaths of kidney cancer increased from 68.14*103 to 138.53*103, and the kidney cancer-related DALYs increased from 1915.49*103 in 1990 to 3284.32*103 in 2017. Then, we searched the GBD database for kidney cancer-related risk factor. The high body-mass index and smoking were the main factors contributing to kidney cancer-related mortality.

Conclusions
Generally, from 1990 to 2017, the incidence rate in developed countries had gone down from the historic peak values while the incidence rate was still on the rise in developing counties. Given the aging trend in the globe, it is necessary to appeal to the public to decrease the exposure of kidney cancer-associated risk factors.
Composing high-level stream processing pipelines
Authors: Mahapatra Tanmaya 
Published: September 2020

AbstractThe growing number of Internet of Things (IoT) devices provide a massive pool of sensing data. However, turning data into actionable insights is not a trivial task, especially in the context of IoT, where application development itself is complex. The process entails working with heterogeneous devices via various communication protocols to co-ordinate and fetch datasets, followed by a series of data transformations. Graphical mashup tools, based on the principles of flow-based programming paradigm, operating at a higher-level of abstraction are in widespread use to support rapid prototyping of IoT applications. Nevertheless, the current state-of-the-art mashup tools suffer from several architectural limitations which prevent composing in-flow data analytics pipelines. In response to this, the paper contributes by (i) designing novel flow-based programming concepts based on the actor model to support data analytics pipelines in mashup tools, prototyping the ideas in a new mashup tool called aFlux and providing a detailed comparison with the existing state-of-the-art and (ii) enabling easy prototyping of streaming applications in mashup tools by abstracting the behavioural configurations of stream processing via graphical flows and validating the ease as well as the effectiveness of composing stream processing pipelines from an end-user perspective in a traffic simulation scenario.
Application of 3D tooth model for monitoring of implant space and inter-root distance without radiographs: a proof of concept study
Authors: Lee Kyungmin , Lee Gyu-Hyoung 
Published: September 2020

Abstract
Background
Radiographs are integral in evaluating implant space and inter-root distance. The purpose of this report is to introduce a method for evaluating the 3D root position with minimal radiation using a 3D tooth model composed of an intraoral-scanned crown and a cone-beam computed tomography (CBCT)-scanned root.

Materials and methods
Intraoral scan and CBCT scan of the patient were obtained before treatment. In the CBCT image, tooth segmentation was performed by isolating individual teeth from the maxillary and mandibular alveolar bone using software program. The 3D tooth model was fabricated by combining segmented individual teeth with the intraoral scan.

Results
A post-treatment intraoral scan was integrated into the tooth model, and the resulting position of the root could be predicted without additional radiographs. It is possible to monitor the root position after a pretreatment CBCT scan using a 3D tooth model without additional radiographs.

Conclusion
The application of the 3D tooth model benefits the patient by reducing repeated radiation exposure while providing the clinician with a precise treatment evaluation to monitor tooth movement.
Laparoscopic repair of a Bochdalek hernia in an elderly patient: a case report with a review from 1999 to 2019 in Japan
Authors: Miyasaka Toshimitsu , Matsutani Takeshi , Nomura Tsutomu , Hagiwara Nobutoshi , Chihara Naoto , Takahashi Koichi , Mishima Keisuke , Taniai Nobuhiko , Yoshida Hiroshi 
Published: September 2020

Abstract
Background
A Bochdalek hernia (BH) is a congenital defect of the diaphragm that generally presents in the newborn as life-threatening cardiorespiratory distress. In contrast, the diagnosis of a BH in adults is rare. Surgical repair for adult BH is recommended, but the optimal surgical method remains unclear.

Case presentation
A 75-year-old woman presented with progressive dyspnea and back pain, and a diagnosis of BH was made based on chest X-ray and computed tomography. Laparoscopic evaluation revealed a defect in the left posterior attachment of the diaphragm, and a left-sided BH without hernia sac was diagnosed. Parts of the stomach, small intestine, colon, pancreas, and spleen had prolapsed into the left thoracic cavity, without ischemic change, and these herniated organs were reduced to the abdominal cavity. A direct closure of the hernia orifice was possible by the laparoscopic suture technique using a mesh reinforcement. The patient made an uneventful recovery, and no recurrence was found in the 2-year follow-up.

Conclusion
A recently published study reviewing detailed cases of repair of adult BH from 1999 to 2019 identified 96 cases, including the present case. The number of reports on laparoscopic and/or thoracoscopic surgery for BH in adults has recently increased, and the approach for repairing BH should be selected carefully on a case-by-case basis.
3D printed mask extenders as a supplement to isolation masks to relieve posterior auricular discomfort: an innovative 3D printing response to the COVID-19 pandemic
Authors: O’Connor Zachary , Huellewig Daniel , Sithiyopasakul Peeti , Morris Jason A. , Gan Connie , Ballard David H. 
Published: September 2020

Abstract
Purpose
Many commonly used mask designs are secured by elastic straps looping around the posterior auricular region. This constant pressure and friction against the skin may contribute to increased wearer pain, irritation, and discomfort. The purpose of this work is to report a modified 3D printed mask extender to alleviate discomfort and increase mask wearability by relieving posterior auricular pressure from isolation masks.

Methods
Our institutional review board designated this project as non-human research and exempt. As part of resourcing 3D printing laboratories along with individual 3D printers to provide resources to healthcare workers, mask extenders were printed to relieve posterior auricular pressure from individuals wearing isolation masks. The authors modifed an existing mask extender, increasing its length with accompanying peripheral rungs for isolation mask securement. 3D printing was performed with Ultimaker S5 (Ultimaker B.V.; Geldermalsen, Netherlands) and CR-10 (Creality3D; Shenzhen, China) 3D printers using polylactic acid filaments. The author’s modified extended mask extenders were printed and freely delivered to healthcare workers (physicians, nurses, technologists, and other personnel) at the authors’ institution.

Results
The final mask extender design was printed with the two 3D printers with a maximum 7 straps printed simultaneously on each 3D printer. Mean print times ranges from 105 min for the Ultimaker S5 printer and 150 min for the CR-10. Four hundred seventy-five mask extenders were delivered to healthcare workers at the authors’ institution, with the demand far exceeding the available supply.

Conclusion
We offer a modification of a 3D printed mask extender design that decreases discomfort and increases the wearability of isolation mask designs with ear loops thought to relieve posterior auricular skin pressure and ability to control strap tension. The design is simple, produced with inexpensive material (polylactic acid), and have been well-received by healthcare providers at our institution.
Cognitive and balance impairments in people with incidental white matter hyperintensities
Authors: Eldin Amr El Sayed Ali Mohamed Tag , Bahnasy Wafik Said , Dabees Naglaa Lotfy , Fayed Hazem Abd El-Rahman 
Published: September 2020

Abstract
Background
White matter hyperintensities (WMHs) is the most frequent type of cerebral small vessel diseases and a common incidental finding in MRI films of the geriatric population. The objectives of this work were to study the existence of occult cognitive and balance impairments in subjects with accidentally discovered WMHs.

Methods
The study was conducted on 44 subjects with accidentally discovered WMHs and 24 non-WMHs subjects submitted to the advanced activity of daily living scale (AADLs), a neurocognitive battery assessing different cognitive domains, Berg balance test (BBT), computerized dynamic posturography (CDP), and brain MRI diffusion tensor tractography (DTT).

Results
WMHs subjects showed a significant decrease in AADLs as well as visual and vestibular ratios of CDP. Regarding the neurocognitive battery, there were significant decreases in MoCA as well as arithmetic test and block design of Wechsler adult intelligence scale-IV in WMHs compared to non-WMHs subjects’ groups (p value < 0.001). Concerning Wisconsin Card Sorting subtests, each preservative response, preservative errors, non-preservative errors and trials to complete the 1st category showed a highly significant increase in WMHs compared to non-WMHs subjects (p values < 0.001). DTT showed a substantial reduction in fractional anisotropy (FA) of each corticospinal tract, thalamocortical connectivity, and arcuate fasciculi.

Conclusion
Subjects with WMHs have lower cognitive performance and subtle balance impairment which greatly impair their ADLs.