bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Digitale Steuerungs-Zwilling
Authors: Herlyn Wilmjakob Johannes , Zadek Hartmut 
Published: April 2020

Kurzfassung
Internationale Technologiekonzerne entwickeln seit einger Zeit ihre Produkte und technischen Anlagen auf Basis des Digitalen Zwillings (DZ) entlang des Produktlebenszyklus. Die virtuelle Betrachtung des Materialflusses und der Auftragsabwicklung als Vernetzung der Anlagen im durchgängigen Kundenauftragsprozess erfolgt hingegen bislang nicht. In diesem Beitrag wird ein Konzept für einen digitalen Steuerungs-Zwilling (DSZ) entworfen, der die Auftragsabwicklung mit dem dazugehörigen Produktions- und Materialfluss aller Objekte eines Unternehmens nach Art, Menge, Ort und Zeit dynamisch steuert, harmonisiert und optimiert.
PELATIHAN PIDATO UNTUK MENINGKATKAN KEPERCAYAAN DIRI SISWA SEKOLAH DASAR DI JAKARTA
Authors: Kartikawati Dwi 
Published: April 2020

Abstract

The problem faced by the partners is the low confidence of elementary school students in public speaking through speech techniques. Whereas these speech skills become a mandatory stage that must be passed in the school exam for graduation. Referring to these problems, charitable activities are carried out by giving speech skills to increase students' confidence level in public speaking. The methods of implementation will be covered in these activity are: (1) providing training to overcome nervousness, (2) training and mentoring in speech practice. The result of the activity is an improvement in the partner's knowledge and skills, so students become more confident and be able to perform in public.

Keywords— Speech, Confidence, Training

Abstrak

Permasalahan yang dihadapi mitra yaitu masih rendahnya kepercayaan diri siswa SD (Sekolah Dasar) dalam berbicara di depan umum melalui teknik berpidato. Padahal ketrampilan berpidato ini menjadi satu tahapan wajib yang harus di lalui dalam ujian sekolah untuk kelulusan. Berangkat dari permasalahan tersebut maka kegiatan pengabdian dilakukan dengan memberikan ketrampilan berpidato untuk meningkatkan kepercayaan diri siswa untuk berbicara di depan umum. Metode pelaksanaan yang dilakukan dalam kegiatan ini adalah : (1) memberikan pelatihan mengatasi rasa gugup, (2) pelatihan dan pendampingan dalam praktek pidato. Hasil dari kegiatan ini adalah meningkatnya pengetahuan dan ketrampilan mitra, sehingga siswa menjadi semakin percaya diri untuk dapat tampil di depan umum

Kata kunci— Pidato, Kepercayaan Diri, Pelatihan
اتجاه الفتاة الجامعية نحو الاستهلاك المظهري - دراسة ميدانية في بغداد
Authors: م.د. فراس يوسف قنبر  
Published: April 2020

في المجتمعات الانسانية كافة نلمح وجوه العملية التبادلية بين الافراد في مجال اشباع الاحتياجات المعيشية باشكال مختلفة ، وهي وان اختلف في ملامحها الا انها دالة على فعل استهلاكي يشبع احتياجات الفرد ويلبي رغباته وفقا لمعايير السلوك المقبول اجتماعياً .
كما نجد ان التباين في صور العملية الاستهلاكية ينتج عن اهمية وشدة الحاجات لدى الافراد من جهة ، وطبيعة البيئة الاجتماعية مكاناً وزماناً والتي يتحدد بمقتضاها اسلوب التفاعل في المجال الاستهلاكي من جهة اخرى ، حيث يتدرج ذلك الاسلوب من المقايضة الى العملية النقدية والتي تمثل الاداة الاساسية في العملية التبادلية الاقتصادية في المجتمع الحديث . وبذلك اصبحت القيمة النقدية تعبر عن السمات القيمية للشيء، ومع التعددية في مسميات العملية النقدية الا انها في جملتها ترفد الحياة الاجتماعية بديناميكية خاصة .
ان العملية الاقتصادية الاجتماعية تعد مفصلا اساسياً من مفاصل النظام الاجتماعي ، ويؤدي الاستهلاك المظهري دوراً يؤشر من خلاله طبيعة الفعاليات الاقتصادية في المجتمع بما يتلاءم مع الحاجة الى الربح ، وبالشكل الذي يكون فيه هذا النوع من الاستهلاك سمة اساسية من سمات السلوك الاجتماعي للفرد في المجتمع الحديث . وفي هذا السياق نجد ان الاهتمام بالاشياء المظهرية والانفاق عليها يتنوع في مساحته تبعاً لمجالات الحياة المختلفة كما تتنوع العوامل المؤثرة فيه .
The Kepler Peas in a Pod Pattern is Astrophysical
Authors: Weiss Lauren M. , Petigura Erik A. 
Published: April 2020

Abstract

Kepler planets around a given star have similar sizes to each other and regular orbital spacing, like “peas in a pod.” Several studies have tested whether detection bias could produce this apparent pattern by resampling planet radii at random and applying a sensitivity function analogous to that of the Kepler spacecraft. However, Zhu argues that this pattern is not astrophysical but an artifact of Kepler's discovery efficiency at the detection threshold. To support this claim, their new analysis samples the transit signal-to-noise ratio (S/N) to derive a synthetic population of bootstrapped planet radii. Here, we examine the procedure of sampling transit S/N and demonstrate it is not applicable. Sampling transit S/N does not set up random, independent planet radii, and so it is unsuitable for corroborating (or falsifying) detection bias as the origin of apparent patterns in planet radius. By sampling the planet radii directly and using a simple model for Kepler’s sensitivity, we rule out detection bias as the source of the peas-in-a-pod pattern with >10σ confidence.
Long-Term Results of Trabeculectomy With Different Concentrations of Mitomycin C in Refractory Developmental Glaucoma
Authors: Özkiris Abdullah , Tamcelik Nevbahar 
Published: April 2020

Purpose:
To evaluate the long-term results of trabeculectomy with two different concentrations of mitomycin C in refractory developmental glaucoma.

Patients and Methods:
A total of 48 eyes of 37 patients with previous failure of congenital glaucoma surgery underwent mitomycin C-augmented trabeculectomy. Data were analyzed retrospectively, and patients were divided into two groups. Group 1 consisted of 18 patients (25 eyes) who underwent trabeculectomy with a 0.4-mg/mL mitomycin C solution and group 2 consisted of 19 patients (23 eyes) who underwent trabeculectomy with a 0.2-mg/mL mitomycin C solution. Pre- and postoperative intraocular pressure (IOP), best-corrected visual acuity, bleb characteristics, success rate, and complications were compared for both groups.

Results:

Mean time between primary surgery and mitomycin C-augmented trabeculectomy was 19.3 months (range, 11 months to 7 years). Mean preoperative IOP was 28.4 ± 2.9 mm Hg in group 1 and 29.0 ± 2.4 mm Hg in group 2. Final postoperative IOP was 17.0 ± 1.6 for group 1 and 17.1 ± 1.4 mm Hg for group 2. There were no significant differences between the groups for IOP, success rate, and complications (
P
> .05). The most common postoperative complication was shallow anterior chamber (11 [22.9%] of 48 eyes).

Conclusions:
A 0.4- or 0.2-mg/mL mitomycin C solution for 4 minutes may be used during trabeculectomy in refractory developmental glaucoma.

J Pediatr Ophthalmol Strabismus
2005;42:97–102.
Unilateral Anterior Transposition and Resection of the Inferior Oblique Muscle for the Treatment of Hypertropia
Authors: Parvataneni Mrunalini , Olitsky Scott E. 
Published: April 2020

Background:
Anterior transposition of the inferior oblique muscle generally is restricted to bilateral cases because of reports of postoperative ipsilateral hypotropia or significant limitation of elevation when performed unilaterally. We performed unilateral anterior transposition of the inferior oblique muscle in patients with vertical and horizontal strabismus who were at risk of anterior segment ischemia.

Patients and Methods:
Six patients underwent unilateral anterior transposition of the inferior oblique muscle in combination with a resection of the inferior oblique muscle. Two patients had lost an inferior rectus muscle in a previous procedure, and four patients had coexistent horizontal and vertical strabismus of various etiologies as well as poor unilateral vision.

Results:
All six patients achieved vertical alignment within 10 prism diopters.

Conclusions:
Unilateral anterior transposition of the inferior oblique muscle appears to be a useful procedure in selected patients with vertical strabismus.

J Pediatr Ophthalmol Strabismus
2005;42:163–165.
Theoretical perspectives on the interaction between warfarin and garlic compounds with an in silico study of CYP3A4
Authors: Saldanha Geovane De Almeida , Bairros André Valle de , Paula Fávero Reisdorfer 
Published: April 2020

Alho (Allium sativum L.) é um dos suplementos alimentares mais consumidos no mundo e tem mpultiplas pripriedades biológicas. Entre todas as moléculas obtidas de alo, S-alil-Lcisteína (SAC), S-metil-L-cisteína (SMC) e S-alilmercaptocisteína (SAMC) são destacadas. Existem estudos in vitro e in vivo que correlacionam as interações destas mléculas com drogas medicinais como varfarina pela competição no sítio de ligação das isenzimas do citocromo P450 (CYP). Varfarina é um anticoagulando oral pertencente à classe dos antagonistas da vitamina K e meraboliza por CYP3A4, 2C9 e 2C19. Este artigo consiste em uma revisão mostrando estudos com extrados e/ou compostos isolados do alho, vias metabólicas e consequências biológicas considerando interações armacológicas. Os resultados revelaram que os extratos de alho expressam uma atividade inibitória em CYP3A4, 2C9 e 2C19. A inibiçã de CYP3A4 foi maior que 50% para SAC e SAMC. O experimento in silico foi realizado para SAC, SMC e SAMC na isoenzima CP3A4 em que SAMC mostrou menor energia de interação (-85, 9Kcal mol-1). (R)-varfarina foi estudada na mesma cavidade molecular deste sítio ativo e mostrou menor valor de energia de interação (-101, 1Kcal mol-1) en comparação com três compostos, que pode suregir que varfarina mostrou melhor afinidade com CYP3a4. Consequentemente, SAMC interage melhor co CYP3A4, seguida de SAC e SMC (-80,4 e 70,2 Kcal mol-1, respectivamente). Estes resultados indicam que mercaptocisteína mostra melhor encaixe com o sítio ativo da CYP3A4 humana. Então, estas interações podem potencializar o risco de sangramento em pacientes durante terapia com varfaria, pois em alguns dos compostos de alho inibem a CYP responsával pela biotransformaço de (R)-varfarina. Estes achados sugerem que o consume de alho deveria ser monitorado em pacientes que recebem terapia anticoagulante com varfarina e os profissionais da saúde devem esta conscientes deste potencial de interação.
ECuADOR—Easy Curation of Angiosperm Duplicated Organellar Regions, a tool for cleaning and curating plastomes assembled from next generation sequencing pipelines
Authors: Armijos Carrion Angelo D. , Hinsinger Damien D. , Strijk Joeri S. 
Published: April 2020

Background
With the rapid increase in availability of genomic resources offered by Next-Generation Sequencing (NGS) and the availability of free online genomic databases, efficient and standardized metadata curation approaches have become increasingly critical for the post-processing stages of biological data. Especially in organelle-based studies using circular chloroplast genome datasets, the assembly of the main structural regions in random order and orientation represents a major limitation in our ability to easily generate “ready-to-align” datasets for phylogenetic reconstruction, at both small and large taxonomic scales. In addition, current practices discard the most variable regions of the genomes to facilitate the alignment of the remaining coding regions. Nevertheless, no software is currently available to perform curation to such a degree, through simple detection, organization and positioning of the main plastome regions, making it a time-consuming and error-prone process. Here we introduce a fast and user friendly software ECuADOR, a Perl script specifically designed to automate the detection and reorganization of newly assembled plastomes obtained from any source available (NGS, sanger sequencing or assembler output).

Methods
ECuADOR uses a sliding-window approach to detect long repeated sequences in draft sequences, which then identifies the inverted repeat regions (IRs), even in case of artifactual breaks or sequencing errors and automates the rearrangement of the sequence to the widely used LSC–Irb–SSC–IRa order. This facilitates rapid post-editing steps such as creation of genome alignments, detection of variable regions, SNP detection and phylogenomic analyses.

Results
ECuADOR was successfully tested on plant families throughout the angiosperm phylogeny by curating 161 chloroplast datasets. ECuADOR first identified and reordered the central regions (LSC–Irb–SSC–IRa) for each dataset and then produced a new annotation for the chloroplast sequences. The process took less than 20 min with a maximum memory requirement of 150 MB and an accuracy of over 99%.

Conclusions
ECuADOR is the sole de novo one-step recognition and re-ordination tool that provides facilitation in the post-processing analysis of the extra nuclear genomes from NGS data. The program is available at https://github.com/BiodivGenomic/ECuADOR/.
Wärmeenergie und Holzfeuchte als Einflussgrößen auf das Abbrandverhalten von Holz
Authors: Werther Norman , Matthäus Carla 
Published: April 2020

AbstractIn diesem Beitrag werden zwei Einflussgrößen betrachtet, die im baupraktischen Anwendungsbereich das Abbrandverhalten von Holz sowie dessen Durchwärmung bei Brandbeanspruchung beeinflussen. Die Kenntnis des Abbrandverhaltens ist eine wesentliche Grundlage für die Bemessung von tragenden Holzbauteilen. Basierend auf Brandversuchen wurde sowohl die Auswirkung von zum Normbrand abweichenden Temperaturbeanspruchungen als auch der Einfluss der Ausgangsholzfeuchte auf das Abbrandverhalten untersucht. In Verbindung mit erweiternden numerischen Untersuchungen wurden hieraus Bemessungsansätze abgeleitet, die die Betrachtung des Abbrand‐ und Durchwärmungsverhaltens von Holzbauteilen unter Norm‐ und parametrischer Brandbeanspruchung erlauben.
Structures and dynamics of DNA complexes of the desmethyl analog of the cytotoxin MLN944: Insights into activity when a methyl isn't futile
Authors: Serobian Andre , Pracey Christopher P. , Thomas Donald S. , Denny William A. , Ball Graham E. , Wakelin Laurence P. G. 
Published: April 2020

AbstractStructure activity relationships for tricyclic‐carboxamide topoisomerase II poisons indicate that cytotoxicity is enhanced by the presence of methyl, and other, groups in the position peri to the carboxamide. Linked dimers of phenazine‐1‐carboxamides are potent cytotoxins and one phenazine dimer, MLN944 (alternatively XR5944), has been in clinical trial. MLN944 is a template inhibitor of transcription, whereas corresponding monomers are not. Nevertheless, its cytotoxic potency is also diminished by removal of its peri methyl groups. Here, we describe NMR and molecular dynamic studies of the interaction of desmethyl MLN944 with d(ATGCAT)2, d(TATGCATA)2, and d(TACGCGTA)2 to investigate the influence of the nine‐methyl group on the structure of MLN944 complexes. As with MLN944, the carboxamide group hydrogen bonds to the phenazine ring nitrogen, the ligand sandwiches the central GC base pairs in the major groove, and the protonated linker amines hydrogen bond primarily to the O6 atom of the guanines. Molecular dynamics studies reveal that the linker exists in multiple conformations, none of which produce an ideal set of hydrogen bonds. In distinction, however, the carboxamide‐to‐phenazine ring nitrogen hydrogen bond is weaker, the overall helix winding is less and the NMR resonances are broader in the desmethyl complexes. Exchange between free and complexed DNA, quantified using two‐dimensional NOESY spectra, is faster for the desmethyl MLN944 complexes than for MLN944 complexes. Overall, the data suggest that desmethyl MLN944 DNA complexes are “looser” and more unwound at the binding site, leading to faster dissociation rates, which could account for the diminished efficacy of the desmethyl analog.
Implementing clinical guidelines into practice: The Osteoarthritis Self‐management and Independent‐living Support (OASIS) group—A service evaluation
Authors: Roberts Shaun , Busby Emma 
Published: April 2020

AbstractIntroductionArthritis is a common diagnosis for people presenting to healthcare reporting joint pain and stiffness. It is estimated that around 10 million people in the United Kingdom are thought to have arthritis. National Guidance states that patients with osteoarthritis should be offered three core treatments: information, exercise and weight loss advice. The Osteoarthritis Self‐management and Independent‐living Support (OASIS) group is a programme of progressive exercise and educational advice.MethodsThis service evaluation was to determine if the OASIS group was improving functional and reported pain‐level outcomes of patients with lower limb osteoarthritis between 2016 and 2018. Routinely collected data were analysed to determine its effects on a number of functional and self‐reported outcomes. Ethical approval was not required following local National Health Service (NHS) Trust approval (Reference e2020‐08).ResultsDuring the 3‐year period of the review between 2016 and 2018, a total of 339 patients were invited to attend the OASIS group. A total of 196 (57.8%) patients improved their overall pain score. Of the patients who attended all six sessions, 96.7% (174) improved in at least one of the functional outcome measures, and 90% (162) improved in at least two functional outcomes.ConclusionOn evaluation of the OASIS group, it has shown to be effective at improving pain and functional performance of patients with lower limb osteoarthritis, whilst remaining cost‐effective. In comparison with other similar initiatives, the results are comparable, and it is implemented over a shorter time period, enhancing the cost‐effectiveness for the NHS.
Numerical modeling of wave propagation in anisotropic viscoelastic laminated materials in transient regime: Application to modeling ultrasonic testing of composite structures
Authors: Imperiale Alexandre , Leymarie Nicolas , Demaldent Edouard 
Published: April 2020

SummaryComposite laminate structures remain an important family of materials used in cutting‐edge industrial areas. Building efficient numerical modeling tools for high‐frequency wave propagation in order to represent ultrasonic testing experiments of these materials remains a major challenge. In particular, incorporating attenuation phenomena within anisotropic plies, and thin intermediate isotropic layers between the plies often represent significant obstacles for standard numerical approaches. In our work, we address both issues by proposing a systematic study of the fully discrete propagators associated to the Kelvin‐Voigt, Maxwell, and Zener models, and by incorporating effective transmission conditions between plies using the mortar element method. We illustrate the soundness of our approach by proposing intermediate one‐dimensional and two‐dimensional numerical evidence, and we apply it to a more realistic configuration of a curved laminate composite structure in a three‐dimensional setting.
Sub‐chronic administration of benzo[a]pyrene disrupts hippocampal long‐term potentiation via inhibiting CaMK II/PKC/PKA‐ERK‐CREB signaling in rats
Authors: Lyu Yi , Ren Xue‐Ke , Zhang Hui‐Fang , Tian Feng‐Jie , Mu Jian‐Bing , Zheng Jin‐Ping 
Published: April 2020

AbstractBenzo[a]pyrene (B[a]P) is recognized as a neurotoxic pollutant to mammals, which could impair learning and memory function. Although there is some evidence to suggest that N‐methyl‐d‐aspartate receptor (NMDAR), a glutamate receptor and ion channel protein in nerve cells, is involved into the B[a]P induced neurotoxicity, the exact molecular mechanisms remain to be elucidated, particularly the effects of B[a]P on the NMDAR downstream signaling transduction pathways. In the present study, we examined the neurotoxicity of sub‐chronic administrated B[a]P on male Sprague‐Dawley rats. Our data suggested that B[a]P exposure caused significant deficits in learning and memory function and the impairment of hippocampal LTP in rats. Further mechanistic studies indicate that B[a]P‐induced learning and memory deficits are associated with the inhibition of NMDAR NR1 subunit transcription and protein phosphorylation. More importantly, the inactivation of CaMK II/PKC/PKA‐ERK‐CREB signaling pathways in hippocampus was detected at both the 2.5 and 6.25 mg/kg B[a]P‐treated groups, indicating that multiple targets in NMDAR and downstream signaling pathways are involved in the B[a]P‐induced neurotoxicity.
Black hole mass measurements in AGN: Polarization in broad emission lines
Authors: Popović Luka Č. , Afanasiev Victor L. , Savić Djordje 
Published: April 2020

AbstractWe present a new method for supermassive black hole (SMBH) mass measurements in Type 1 active galactic nuclei (AGN) using polarization angle across broad lines. This method gives measured masses which are in a good agreement with reverberation estimates. Additionally, we explore the possibilities and limits of this method using the STOKES radiative transfer code taking a dominant Keplerian motion in the broad line region (BLR). We found that this method can be used for the direct SMBH mass estimation in the cases when in addition to the Kepler motion, radial inflows or vertical outflows are present in the BLR. Some advantages of the method are discussed.
Jet production efficiency in the sample of the youngest radio galaxies
Authors: Wójtowicz Anna , Stawarz Łukasz , Kosmaczewski Emily 
Published: April 2020

AbstractWe investigate the sample of 16 the youngest radio galaxies with measured kinematic ages and available X-ray data from high-resolution Chandra or XMM-Newton observations. We characterize the accretion properties and derive the jet kinetic luminosities for our sources. We found high accretion rates (>1% Eddington) and very high jet production efficiency for all the sources from our sample.This, along with the fact that the analyzed objects seem over-luminous in radio on the fundamental plane for the black hole activity, implies also that the radiative efficiency of the compact lobes is much higher than in the case of the evolved radio galaxies.
Update on the Multi-Frequency Monitoring of Blazars with Medicina and Noto
Authors: Righini Simona , Cassaro Pietro , Bach Uwe , Giroletti Marcello , Buemi Carla , Leto Paolo , Orienti Monica , Orlati Andrea , Raiteri Claudia M. , Trigilio Corrado , Umana Grazia , Villata Massimo 
Published: April 2020

AbstractThe Medicina and Noto radiotelescopes have been employed for over 14 years to monitor the flux density variations of a vast sample of blazars at different radio frequencies. Radio data are essential components of blazar spectral energy distribution (SED, spanning from radio waves to gamma rays), whose trend with luminosity and shape changes provide decisive information on the physics of extra-galactic jets and, eventually, on the mechanism extracting energy from the central black hole in radio-loud AGN. Observations presently carried out at 5, 8 and 24 GHz have taken advantage of the continually evolving control system installed at the antennas. A new, batch-wise analysis tool was also produced, in order to easily handle and reduce the datasets acquired in monthly sessions. We here describe the latest developments and achievements.
External blob radiation model for the TeV gamma-ray emission in radio galaxies
Authors: Bednarek Wlodek , Banasiński Piotr 
Published: April 2020

AbstractWe propose that two emission regions are present in the decelerating jet of radio galaxy at this same moment. Isotropic electrons, in the farther blob as counted along the jet, up-scatter mono-directional soft radiation, from the closer blob, at a relatively large angles to the jet axis. Such model can naturally explain the large angle gamma-ray emission observed from radio galaxies.