bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model
Authors: Machida Yukino , Nakagawa Makoto , Matsunaga Hironori , Yamaguchi Masayuki , Ogawara Yoko , Shima Yutaka , Yamagata Kazutsune , Katsumoto Takuo , Hattori Ayuna , Itoh Masato , Seki Takahiko , Nishiya Yumi , Nakamura Koichi , Suzuki Kanae , Imaoka Tomoki , Baba Daichi , Suzuki Makoto , Sampetrean Oltea , Saya Hideyuki , Ichimura Koichi , Kitabayashi Issay 
Published: November 2019

Abstract
Gliomas are the second most common primary brain tumors in adults. They are treated with combination therapies, including surgery, radiotherapy, and chemotherapy. There are currently limited treatment options for recurrent gliomas, and new targeted therapies need to be identified, especially in glioblastomas, which have poor prognosis. Isocitrate dehydrogenase (IDH) mutations are detected in various tumors, including gliomas. Most patients with IDH mutant glioma harbor the IDH1R132H subtype. Mutant IDH catalyzes the conversion of α-ketoglutarate to the oncometabolite 2-hydroxyglutarate (2-HG), which induces aberrant epigenetic status and contributes to malignant progression, and is therefore a potential therapeutic target for IDH mutant tumors. The present study describes a novel, orally bioavailable selective mutant IDH1 inhibitor, DS-1001b. The drug has high blood–brain barrier (BBB) permeability and inhibits IDH1R132H. Continuous administration of DS-1001b impaired tumor growth and decreased 2-HG levels in subcutaneous and intracranial xenograft models derived from a patient with glioblastoma with IDH1 mutation. Moreover, the expression of glial fibrillary acidic protein was strongly induced by DS-1001b, suggesting that inhibition of mutant IDH1 promotes glial differentiation. These results reveal the efficacy of BBB-permeable DS-1001b in orthotopic patient-derived xenograft models and provide a preclinical rationale for the clinical testing of DS-1001b in recurrent gliomas.
Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer
Authors: Inda Márcia A. , Blok Erik J. , Kuppen Peter J.K. , Charehbili Ayoub , den Biezen-Timmermans Eveline C. , van Brussel Anne , Fruytier Sevgi E. , Meershoek-Klein Kranenbarg Elma , Kloet Susan , van der Burg Bart , Martens John W.M. , Sims Andrew H. , Turnbull Arran K. , Dixon J. Michael , Verhaegh Wim , Kroep Judith R. , van de Velde Cornelis J.H. , van de Stolpe Anja 
Published: November 2019

Abstract
Endocrine therapy is important for management of patients with estrogen receptor (ER)–positive breast cancer; however, positive ER staining does not reliably predict therapy response. We assessed the potential to improve prediction of response to endocrine treatment of a novel test that quantifies functional ER pathway activity from mRNA levels of ER pathway–specific target genes. ER pathway activity was assessed on datasets from three neoadjuvant-treated ER-positive breast cancer patient cohorts: Edinburgh: 3-month letrozole, 55 pre-/2-week/posttreatment matched samples; TEAM IIa: 3- to 6-month exemestane, 49 pre-/28 posttreatment paired samples; and NEWEST: 16-week fulvestrant, 39 pretreatment samples. ER target gene mRNA levels were measured in fresh-frozen tissue (Edinburgh, NEWEST) with Affymetrix microarrays, and in formalin-fixed paraffin-embedded samples (TEAM IIa) with qRT-PCR. Approximately one third of ER-positive patients had a functionally inactive ER pathway activity score (ERPAS), which was associated with a nonresponding status. Quantitative ERPAS decreased significantly upon therapy (P &lt; 0.001 Edinburgh and TEAM IIa). Responders had a higher pretreatment ERPAS and a larger 2-week decrease in activity (P = 0.02 Edinburgh). Progressive disease was associated with low baseline ERPAS (P = 0.03 TEAM IIa; P = 0.02 NEWEST), which did not decrease further during treatment (P = 0.003 TEAM IIa). In contrast, the staining-based ER Allred score was not significantly associated with therapy response (P = 0.2). The ERPAS identified a subgroup of ER-positive patients with a functionally inactive ER pathway associated with primary endocrine resistance. Results confirm the potential of measuring functional ER pathway activity to improve prediction of response and resistance to endocrine therapy.
Breeding Beyond Bodies: Making and “Doing” Cattle
Authors: Petitt Andrea , Eriksson Camilla 
Published: November 2019

Abstract
Dairy cows provide a spectacular example of what can be achieved with purposeful breeding of nonhuman animals in terms of increasing production and bodily adaptation to particular production systems. This implies that humans can make nonhuman bodies take whatever form they desire. However, the assumption that breeding outcomes are entirely shaped by humans has been criticized. This article contributes to ongoing discussions of breeds as socially constructed and applies a focus on cattle actions. Within a more-than-human biopower framework, cattle actions and ways of “doing” cattle are integral to both the notion and the future of the breed. This ethnography of breeding Swedish Mountain Cattle provides a detailed account of the mutual subjectification of cattle and farmers within an agricultural context, revealing the scope and limits of cattle agency and how “doing” cattle affects individuals and populations.
Mitigating the Necessity of the Past in the Second Half of the Twelfth Century: Future-Dependent Predestination
Authors: Wciórka Wojciech 
Published: November 2019

AbstractEarly twelfth-century logicians invoked past-tensed statements with future-oriented contents to undermine the assumption that every proposition ‘about the past’ is determinate. In the second half of the century, the notion of future-dependence was used to restrict the scope of necessity per accidens (e.g., in the Ars Meliduna). At some point, this idea began to be applied in theology to solve puzzles surrounding predestination, prescience, prophecy, and faith. In the mid-1160s, Magister Udo quotes some thinkers who insisted that the principle of the necessity of the past should exclude dicta that ‘relate to the future’, such as that he has been predestined. Peter of Poitiers adopted this ‘Ockhamist’ strategy around 1170. We find similar accounts in Simon of Tournai and Alan of Lille, who invoked it in other contexts as well. By the time of Praepositinus of Cremona, Hubert of Pirovano, and Stephen Langton, the restricted principle became something of a common view at Paris.
Decadal Changes in the Interannual Variability of Heat Waves in East Asia Caused by Atmospheric Teleconnection Changes
Authors: Choi Nakbin , Lee Myong-In , Cha Dong-Hyun , Lim Young-Kwon , Kim Kyu-Myong 
Published: November 2019

AbstractThe heat wave in East Asia is examined by using empirical orthogonal function analysis to isolate dominant heat-wave patterns in the ground-based temperature observations over the Korean Peninsula and China and related large-scale atmospheric circulations obtained from the National Centers for Environmental Prediction–National Center for Atmospheric Research Reanalysis 1 during 1973–2012. This study focuses particularly on the interannual variability of heat waves and its decadal change. The analysis identifies two major atmospheric teleconnection patterns playing an important role in developing typical heat-wave patterns in East Asia—the Scandinavian (SCAND) and the circumglobal teleconnection (CGT) patterns, which exhibit a significant decadal change in the interannual variability in the mid-1990s. Before the mid-1990s, heat-wave occurrence was closely related to the CGT pattern, whereas the SCAND pattern is more crucial to explain heat-wave variability in the recent period. The stationary wave model experiments suggest an intensification of the SCAND pattern in the recent period driven by an increase in land–atmosphere interaction over Eurasia and decadal change in the dominant heat-wave patterns in East Asia.
Varieties of Neoliberalism in Brazil (2003–2019)
Authors: Saad-Filho Alfredo 
Published: November 2019

The main feature of capital accumulation in Brazil during the administrations led by Luís Inácio Lula da Silva and Dilma Rousseff of the Partido dos Trabalhadores (Workers’ Party—PT) was the continuity of neoliberalism of two varieties: inclusive (2003–2006) and developmental (2006–2013). The PT’s attachment to neoliberalism was mitigated by the party’s (shifting) commitment to (mild) developmental outcomes, redistribution of income (at the margin), social inclusion (within narrow limits), and democratization of the state (bounded by the 1988 Constitution). Achievements in these areas were further constrained by the inability or unwillingness of the PT to confront the institutionalization of neoliberalism in the fields of economics, politics, ideology, the media, and class relations. The political crisis unfolding in Brazil since 2013 and the imposition of authoritarian neoliberalism after Rousseff’s impeachment can be examined from the perspective of the contradictions in the dominant varieties of neoliberalism under the PT and the limitations of the party’s political ambitions. A principal característica da acumulação de capital no Brasil durante os governos ûiderados por Luís Inácio Lula da Silva e Dilma Rousseff do Partido dos Trabalhadores (PT) foi a continuidade do neoliberalismo de duas variedades: inclusiva (2003–2006) e desenvolvimentista (2006–2013). O apego do PT ao neoliberalismo foi mitigado pelo compromisso (inconstante) do partido com resultados de desenvolvimento (moderados), redistribuição de renda (na margem), inclusão social (dentro de limites estreitos) e democratização do estado (limitado pela Constituição de 1988). As realizações nessas áreas foram ainda mais limitadas pela incapacidade ou falta de vontade do PT em enfrentar a institucionalização do neoliberalismo nos campos da economia, política, ideologia, mídia e relações de classe. A crise política que se desenrola no Brasil desde 2013 e a imposição do neoliberalismo autoritário após o impeachment de Dilma podem ser examinadas sob a perspectiva das contradições nas variedades dominantes de neoliberalismo sob o PT e as limitações das ambições políticas do partido.
Intraoperative Radiographic Assessment of Bone Resection Margins During Mandibulectomy: A Case Series
Authors: Shan Alan , Boahene Kofi , Pitman Karen T. , Blanco Ray G. 
Published: November 2019

Background and Purpose: Mandibulectomy remains the treatment of choice for oral cavity squamous cell carcinoma with infiltration of bone and for benign tumors with full mandibular thickness involvement. Although bone resection margins are critical for patient outcomes, intraoperative immediate bone margins assessment is inadequate, and few alternative options have been described. The purpose of this study was to describe the use of an existing intraoperative radiographic system for objective determination of bone resection margins during mandibulectomy. Methods: We conducted a retrospective case series of all patients at the Greater Baltimore Medical Center who underwent mandibulectomy and received intraoperative Faxitron radiography from January 1, 2016, to March 1, 2019. Patient characteristics including age, sex, diagnosis, tumor location, clinical and pathologic stage, procedure performed, and bone resection margins were reviewed. Results: A total of 10 patients underwent mandibulectomy with intraoperative radiography. Nine (90%) received surgery for squamous cell carcinoma, with 1 (10%) for ameloblastoma. Out of those with squamous cell carcinoma, tumor location varied, and all were clinically stage T4. Final pathologic margins were negative in all cases (10/10), though in 2 cases, close margins were assessed intraoperatively, leading to further resection or change in operative plan. Conclusion: Intraoperative radiographic assessment of bone resection margins is a promising technique, though further validation is required.
A Contemporary Look at the Evaluation and Treatment of Adult Borderline and Frank Hip Dysplasia
Authors: Kraeutler Matthew J. , Safran Marc R. , Scillia Anthony J. , Ayeni Olufemi R. , Garabekyan Tigran , Mei-Dan Omer 
Published: November 2019

Background: Adult hip dysplasia is often diagnosed according to the lateral center-edge angle (LCEA). Patients with frank hip dysplasia (LCEA <20°) traditionally require treatment with bony realignment through a periacetabular osteotomy (PAO) and/or derotational femoral osteotomy, while patients with borderline hip dysplasia (BHD) present a challenging treatment dilemma, as it remains unknown when they should be treated with hip arthroscopy and/or a PAO. Purpose: To perform a narrative review to report the differences in hip morphology and clinical outcomes between adult patients with frank hip dysplasia and BHD. Study Design: Narrative review. Methods: A systematic search of the literature was conducted through the Medline, EMBASE, and Cochrane databases with the search phrase borderline hip dysplasia. Results: The search identified 305 articles, of which 48 were considered relevant to this study after screening of titles and abstracts. Four articles discussed new radiographic means of evaluating adult hip dysplasia, 16 articles analyzed morphology of dysplastic hips, and 28 articles described the clinical outcomes of patients with frank hip dysplasia or BHD treated with hip arthroscopy and/or PAO. Because the level of evidence obtained from this search was not adequate for systematic review or meta-analysis, a current concepts review on the diagnosis, hip morphology, and clinical outcomes of patients with frank hip dysplasia or BHD is presented. Conclusion: Adult hip dysplasia is most commonly diagnosed based on the LCEA; however, the LCEA is an unreliable sole marker for dysplasia, and additional radiographic parameters should be utilized. Furthermore, specific pathology identified on imaging and/or during hip arthroscopy can provide clues to a surgeon when the diagnosis is inconclusive according to history and physical examination alone. While the data support that patients with frank dysplasia are best treated with PAO, there is no such preferred treatment for patients with BHD, who have a wide spectrum of instability. Selective use of arthroscopic labral and capsular treatment alone may provide good results in carefully chosen patients with BHD, while some may end up requiring a bony realignment procedure.
Clinicopathological and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012–2018)
Authors: Aslam Muhammad Waseem , Lau Seng Fong , Chin Chelly Sze Lee , Ahmad Nur Indah , Rahman Nor-Alimah , Kuppusamy Krishnammah , Omar Sharina , Radzi Rozanaliza 
Published: November 2019

Objectives This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological features, therapeutic plans and outcomes for cats infected with Rhodococcus equi. Methods Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diagnosed with rhodococcosis between 2012 and 2018 were recruited in this study. Medical records were reviewed for information on signalment, history, clinical presentation, diagnostic testing, treatment plans and clinical outcomes. Results Of the 40 cats, 36 showed the pulmonary form of the disease, with 35 (87.5%) presenting with dyspnoea, while four cats presented with only cutaneous lesions. Mean body temperature was 38.7 ± 0.2°C. Dyspnoea was noted in 87.5% of the cats. Leukocytosis (58.3%) with band neutrophilia (83.3%), monocytosis (58.3%) and thrombocytopenia (55.5%) were prominent findings in the haematology reports. Hyperproteinaemia (61.1%) with hypoalbuminaemia (22.2%) and hyperglobulinaemia (63.8%) with a low albumin:globulin ratio (38.9%) were prominent features of blood biochemistry reports. An alveolar–interstitial pattern was noted in 75% of pre-thoracocentesis radiographs. Pleural effusion, hepatomegaly, thoracic lymphadenopathy and atelectasis of any lung lobe were seen in 88.9%, 75%, 41.7% and 36.1% of cats, respectively. Overall, the mortality rate was 67.5% in both forms. Conclusions and relevance Clinicians should be aware that feline rhodococcosis manifests as a pulmonary disease at a much higher rate than previously reported. Further studies are required to address the epidemiology, pathophysiology, disease management and prognosis of feline rhodococcosis. The role of immunosuppression as a predisposing factor in feline rhodococcosis requires further investigation.
Perceived health competence predicts anxiety and depressive symptoms after a three-year follow-up among adolescents and adults with congenital heart disease
Authors: Leslie Carine E , Schofield Kyle , Vannatta Kathryn , Jackson Jamie L 
Published: November 2019

Background: Congenital heart disease places survivors at increased risk for cardiovascular complications as they age and requires long-term medical management. Perceived health competence, or how capable one feels in managing one’s health, is linked to emotional adjustment in various disease populations, but has not been investigated among congenital heart disease survivors. Aim: The purpose of this study was to examine the relationship of perceived health competence at baseline (T1) as a predictor of anxiety and depressive symptoms three years later (T2). Methods: Congenital heart disease survivors ( n=125; MT1age=27; 58.6% female; severity of cardiac lesion: 25% simple, 44% moderate, 31% complex) were recruited from a pediatric and an adult hospital as part of a larger study. Participants completed the Perceived Health Competence Scale and the Youth or Adult Self-Report at T1 for anxiety and affective/depressive symptoms. At T2, participants completed the Hospital Anxiety and Depression Scale. New York Heart Association functional class, a measure of functional impairment, was abstracted from medical charts at T2. Results: Lower T1 perceived health competence was significantly associated with greater emotional distress at T1 (depression r=−0.47; anxiety: r=−0.45), as well as greater T2 functional impairment ( r=−0.41). T1 perceived health competence also predicted T2 anxiety and depressive symptoms, which remained significant when including T1 anxiety and depressive symptoms and T2 functional impairment. Conclusion: Congenital heart disease survivors who feel more competent in managing their health may be less likely to experience future anxiety and depressive symptoms. Perceived health competence may be a worthwhile target for psychosocial intervention to promote emotional wellbeing among congenital heart disease survivors and ensure the best outcomes.
Unfavourable early outcomes of total trapeziectomy with RegJoint™ interposition: a report of 38 osteoarthritic hands in 34 patients
Authors: Mattila Simo , Haapamäki Ville , Waris Eero 
Published: November 2019

This retrospective study analysed the results of total trapeziectomy with RegJoint™ interposition in 38 osteoarthritic hands in 34 patients. Patients were evaluated preoperatively, at follow-up visits, and at a mean final follow-up of 33 months (range 20–53) with plain radiographs, computed tomography, as well as with subjective and objective evaluations. Pain decreased and subjective outcomes and function improved significantly. Computed tomography 18 months after operation showed osteolysis in 24 cases. Three patients developed wrist pain 12–18 months after operation with MRI findings of a foreign-body reaction in each case. One of these patients was scheduled for revision surgery. Although the clinical results were satisfactory, the risk of foreign-body reaction and osteolysis is noteworthy. We conclude that the use of RegJoint™ should be reconsidered since the implant probably offers no benefit in the treatment of trapeziometacarpal osteoarthritis. Level of evidence: IV
A modified Terrono classification for Type 1 thumb deformity in rheumatoid arthritis: a cross-sectional analysis
Authors: Toyama Shogo , Oda Ryo , Asada Maki , Nakamura Satoru , Ohara Masato , Tokunaga Daisaku , Mikami Yasuo 
Published: November 2019

The most common thumb deformity in rheumatoid arthritis is Nalebuff Type 1 deformity (boutonniere deformity). Type 1 deformity severely impairs hand function, and this impairment is evaluated by the Terrono classification. In some cases, the Terrono classification incorrectly categorizes advanced thumb deformity into earlier stages. We modified the Terrono classification by assessing the active range of motion of the interphalangeal joint prior to assessing the passive range of movement of the metacarpophalangeal joint. An active range of movement of the interphalangeal joint was strongly correlated with hand function. In 55 hands that we treated between 2004 and 2015, we compared the modified classification with the original Terrono classification. Our modified classification could detect advanced deformity earlier, and was more strongly correlated with hand function. Additionally, correlation analysis showed that advanced Type 1 deformity should be treated first, even in cases with severe ulnar drift. Our results suggest that the modified classification may benefit the treatment of Type 1 deformity, including joint-preserving surgery. Level of evidence: III
Prognosis of combined pulmonary fibrosis and emphysema: comparison with idiopathic pulmonary fibrosis alone
Authors: Jiang Chun-guo , Fu Qiang , Zheng Chun-ming 
Published: November 2019

Background: Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome characterized by the coexistence of upper lobe emphysema and lower lobe fibrosis. However, whether CPFE has a higher or lower mortality than idiopathic pulmonary fibrosis (IPF) alone is still not clear. In this study we conducted a meta-analysis to assess the survival rate (SR) of CPFE versus IPF alone in clinical trials. Methods: We performed a systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials for trials published prior to 31 March 2018. Extracts from the literature were analyzed with Review Manager version 5.3. Results: Thirteen eligible trials were included in this analysis (involving 1710 participants). Overall, the pooled results revealed that no statistically significant difference was detected in the 1-year [relative risk (RR) = 0.98, 95% confidence interval (CI): 0.94–1.03, p = 0.47], 3-year (RR = 0.83, 95% CI: 0.68–1.01, p = 0.06), and 5-year (RR = 0.80, 95% CI: 0.59–1.07, p = 0.14) SRs of CPFE versus IPF alone. Conclusions: CPFE exhibits a very poor prognosis, similar to IPF alone. Additional studies are needed to provide more convincing data to investigate the natural history and outcome of patients with CPFE in comparison to IPF. The reviews of this paper are available via the supplemental material section.