bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inpatient prescribing of dual antiplatelet therapy according to the guidelines: a prospective intervention study
Authors: Moerlie Ashwin R. , Van Uden Renate C. , Mantel Aukje K. , Van den Bemt Patricia , Becker Matthijs L. 
Published: June 2020

Background: In dual antiplatelet therapy (DAPT), low-dose acetylsalicylic acid is combined with a P2Y12 inhibitor. However, combining antithrombotic agents increases the risk of bleeding. Guidelines on DAPT recommend using this combination for a limited period of between three weeks and 30 months. This implies the risk of DAPT being erroneously continued after the intended stop date.
Objective: The primary objective of this study is to assess the proportion of hospitalized patients treated with DAPT whose treatment deviated erroneously and unintentionally from the guidelines. We also assessed risk factors and the effect of a pharmacist intervention.
Methods: All patients admitted to the Spaarne Gasthuis (Haarlem/ Hoofddorp, the Netherlands) who used DAPT between March 25th, 2019, and June 14th, 2019, were, in addition to receiving regular care, reviewed to assess whether their therapy was in line with the guidelines’ recommendation and whether deviations were unintended and erroneous. In the event of an unintended deviation, the pharmacist intervened by contacting the prescriber by phone and giving advice to adjust the antithrombotic therapy in line with the guideline.
Results: We included 411 patients, of whom 21 patients (5.1%) had a treatment that deviated from the guidelines. For 11 patients (2.7%), the deviation was unintended and erroneous. The major risk factor for erroneous deviation was the use of DAPT before hospital admission (OR 18.7; 95%CI 4.79–72.7). In patients who used DAPT before admission, 18 out of 58 (31.0%) had a deviation from the guidelines of whom 8 (13.8%) were erroneous. For these eight patients, the pharmacist contacted the prescriber, and in these cases the therapy was adjusted in line with the guidelines.
Conclusions: Adherence to the guidelines recommending DAPT was high within the hospital. However, patients who used DAPT before hospital admission had a higher risk of erroneous prescription of DAPT. Intervention by a pharmacist increased adherence to guidelines and may reduce the number of preventable bleeding cases.
¿El embarazo en adolescentes es siempre de alto riesgo?
Authors: Duarte Contreras Alberto 
Published: June 2020

Al estudiar 1.335 embarazos en adolescentes hasta de 16 años encontramos una incidencia de un embarazo por cada 66 pacientes del Servicio. El 10.35% terminaron en aborto. La Toxemia se presentó en el 11.5%. El 74.8% de los partos fueron espontáneos, 9.5% por fórceps, 9.3% por vacuum y 6.4% por operación cesárea. El 12% de los partos fueron prematuros. Las complicaciones obstétricas fueron inferiores a las del grupo de mayor edad. La duración del trabajo de parto fue de 12 horas.Tuvimos mortalidad materna de 0.3% en eclámpjticas. El 16.8% de los productos tuvieron un peso inferior a los 2.500 gramos. El 3.4% de los productos fueron mortinatos y el 3.4% mortineonatos. En el 1% de los recién nacidos hubo malformaciones congénitas aparentes. Se dan conclusiones.
La operación de Wertheim-Meigs en el carcinoma cérvico-uterino en la etapa clínica I. - 1966-1975
Authors: Peralta Quintero Armando , Camacho Emilio , Mitjans O. D. , Cabrera E. , Pacheco Emma , Díaz Cuesta E. 
Published: June 2020

A un criterio uniforme en lo que se refiere a la mejor terapéutica del cáncer del cuello uterino no se ha llegado aún en la Ginecología.
The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients
Authors: Efendiyev A. M. , Azizova G. I. , Huseynova G. R. 
Published: June 2020

We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity.
Activity of kallikrein-kinin system in children in norm and at some pathological states
Authors: Kondratiyeva Ye. I. , Tropova T. Ye. , Sukhanova G. A. , Terentiyeva A. A. , Krivonogova T. S. , Gorev V. V. , Stepanenko N. P. , Tyuteva Ye. Yu. 
Published: June 2020

Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. We have studied the activity of kallikrein, kallikreinogen, angiotensine transforming enzyme, α1-protease inhibitor, and α2-macroglobulin in healthy children in different age periods, in newborns with hypoxic-ischemic encephalopathy, in children with infectious-inflammatory diseases of the urinary system, obesity, and metabolic syndrome.The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.
Method of drainage of retroperitoneal fat at infected pancreatonecrosis
Authors: Merzlikin N. N. , Kuznetsov A. V. , Barabash V. I. , Sorokin R. V. 
Published: June 2020

The aim of this study was to improve the results of treatment of patients with infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat. Toward this end, the following tasks were formulated: to develop a new way of drainage of the retroperitoneal fat at infected pancreatonecrosis — retroperitoneostomy and to analyze comparatively the efficiency of traditional methods of drainage of the pancreatic gland zone at infected pancreatonecrosis (omnetobursotomy, lumbostomy) with retroperitoneostomy.The analysis was based on the results of examination and treatment of 60 patients with pancreatonecrosis complicated with phlegmon of retroperitoneal fat, who were operated in surgical departments of the Tomsk municipal hospital no. 3 in 2004—2008.The use of retroperitoneostomy in the treatment of infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat decreased postsurgical complications from 36.6 to 15.79% and lethality from 56.1 to 21,0%.
Application broncho-phonography investigation for an estimation of respiratory frustration at immature infants with a respiratory distress-syndrome
Authors: Pavlinova Ye. B. , Oksenchuk T. B. , Krivtsova L. A. 
Published: June 2020

Respiratory distress syndrome of the newborn is a basic pathobiology immature infants and this grave condition of early neonatal period often is the cause of chronic lung disease — bronchopulmonary dysplasia (BPD). BPD is marked by hyperreactivity of bronchi. The growth of this pathobiology in view of survival of immature infant is increasing in recent years. To measure functional status of respiratory tracts of infants with classical methods (spirography) is impossible. But there is a new method of diagnostics of broncho-obstructive syndrome, it is broncho-phonography. This method is noninvasive and can be used without active patient’s part in investigation. The examination results of immature infants with respiratory distress syndrome and with bronchopulmonary dysplasia (BPD) with the help of broncho-phonography method are described in the article.The results of respiratory patterns of immature infants are normal in spite of their disease. That’s why we can speak about usage of broncho-phonography method in differential diagnostics of wheezing and restrictive dysplasia.
Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1
Authors: Zaidman A. M. , Mikhailovsky M. V. , Zaviyalova Ye. L. , Suzdalov V. A. , Sadovoy M. A. 
Published: June 2020

To study pathogenetic mechanisms of the development of spinal deformity in neurofibromatosis.Structural components of the spine were presented as specimens obtained after surgical correction of spinal deformity performed in 10 children with III—IV grade scoliosis associated with neurofibromatosis.Etiologic factor of the development of spinal deformity in neurofibromatosis is a mutation of the NF-1 gene in cells of ganglious lamella. Migration of cells carrying mutant gene into one of the sclerotome zones results in oncogene activation and intensive proliferation of chondro-, osteo-, and fibroblasts in the growth plate, intervertebral disc, and vertebral body.Progressive development of the spinal deformity after surgical intervention is accounted both for proliferation of chondro- and fibroblasts in the vertebral body and intervertebral disc and for disturbance of the NF-1 and lumican genes expression.
An experiment of Kartalin liniment for palmar-plantar form psorias and other keratodermias
Authors: Dmitruk V. S. 
Published: June 2020

Keratodermias can be isolated or can be a part of syndromes typical for other dermatological deceases. Investigation of clinical effectiveness of Kartalin liniment in complex therapy of palmar-plantar keratodermias was held with a group of 26 patients with different clinical variants of the deceases. Besides local treatment, the patients got systematic therapy corresponding to the standards of medical treatment for each nogological form.For estimation of clinical effectiveness of the suggested complex of general and local arrangements there was done a calculation of the number of days spent in hospital white curing keratodermias. This showing made up 23 days in the examined group and positive clinical dynamics in the control group has been noticeable sense 33,7 day.
Potentialities of the ultrasonography by detection of the acromion types as external cause of impingment syndrome
Authors: Kinzersky A. Yu. , Turdakina I. N. 
Published: June 2020

It is on record that the curved and hooked acromion types result in the lesion in the rotator cuff tendons. Research aim: to increase the informational content of ultrasound investigation of a glenohumeral joint using ultrasonic analysis of acromial morphology. To research is based on the comparison of radiographic findings of the acromion with the length of coraco-acromial ligament. Altogether 112 patients aged from 21 to 80 which complained the shoulder pain were examined. Among them there were 76 (67,9%) women and 36 (32,1%) men.The length of the coracoacromial ligament was defined for each type of acromion process.Conclusion: we found ultrasound equivalent (the length of coracoacromial ligament) for each type of acromion, which allows to reduce radiation exposure of the patients while their examination.
Endothelial dysfunction and hemostasis in acute myocardial infarction before and after Trombovazim therapy
Authors: Kotovshchikova Ye. F. , Buevich Ye. I. , Syulzhina Ye. N. , Tarasova I. N. , Vereschagin Ye. I. , Popova L. A. 
Published: June 2020

We studied 57 patients with acute myocardial infarction (AMI) aged 20 to 63 years. Initially (day 25 from disease onset), Fibroblast growth factor (FGF), osteoprotegerin, vascular endothelial growth factor (VEGF-A), von Willebrand factor (vWF) were determined in patients’ blood by immunoenzyme method; hemostasis system was examined. The control group consisted of 15 healthy volunteers aged 19 to 50 years. The patients were divided into two groups: the major group was receiving Trombovazim in dosage 800 mg per day during 1 month together with the standard therapy of AMI, and the control group, which was receiving no Trombovazim. Control study of the dynamics of FGF, osteoprotegerin, VEGF-A, vWF, and hemostasis hemostasis parameters was performed after 1 month of treatment with Trombovazim. The inclusion of Trombovazim into the complex therapy of AMI was found to result in a decrease in FGF, osteoprotegerin, and VEGF-A levels due to the endothelial protection effect and apoptosis control.The parameters of vascular-platelet and coagulation hemostasis components had no significant changes.
Investigation of rubella vaccine maked MICROGEN Federal State Company: study I trial
Authors: Mironov A. N. , Tsaan A. A. , Bushmenkov D. S. , Romanova A. A. , Sidorenko Ye. S. , Feldblum I. V. 
Published: June 2020

Experts of the RPU «Microgene», developed the new domestic medication for prevention of rubella — The rubella vaccine cultural live, on the basis of the vaccine strain RA 27/3. After the safety of vaccine had been proved on laboratory animals, the clinical trial had been activated on volunteers.The first phase of trial had been carried out on the women at the age of 18—25.After introduction of medications (vaccine or production strain of vaccine) the volunteers had been observed during 42 days. Blood and urine sampling had been executed till vaccination and 28 days later after introduction of medications.Results of trial presented safety, low reactogenicity and evident immunologic properties of medications. It permitted to start the next phase of the clinical trial on the basis of children’s volunteers.
THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS
Authors: Khokhlov O. A. 
Published: June 2020

The composition of lipid phase of red-cell membrane in patients with ischemic heart disease (IHD) with pronounced postperfusion hemolysis (18 patients) before coronary artery bypass surgery and 1 hour after the completion of cardia bypass (CB) has been studied. It is shown that patients with IHD with pronounced hemolysis are characterized by the normal ratio of phospholipids (PL) fractions in red-cell membrane before surgery, which is connected with eth high content of young forms of red cells in blood at this stage. After surgery, the fraction of lysophosphatidylcholine and phosphatidic acid in red-cell membrane increases against the background of decrease of phosphatidylinositol and phosphatidylcholine, which likely reflects the simultaneous activation of phospholipases of three classes (A, C, and D) in red cells during CB. Regardless of the phase of the study, the total content of PL in red-cell membrane of IHD patients with pronounced hemolysis is decrease at the high level of cholesterol (CS) and the CS/Pl ratio.
BIOBEHAVIORAL THERAPY OF RHEUMATOID ARTHRITIS
Authors: Shabanova N. A. , Shubina O. S. , Ukolova L. A. , Tov N. L. 
Published: June 2020

The relevance of the study is connected with need to expand the arsenal of treatment methods patients with rheumatoid arthritis. The study examined the efficacy of biobehavioral therapy in a comprehensive program of treatment patients with rheumatoid arthritis (medical therapy in combination with biobehavioral therapy). It has been shown when compared with the control group (isolated drug therapy) maintaining clinical response in short-term follow-up study in the intervention group. Statistically significant relationship the volitional control of the alpha rhythm of EEG (increased power of the alpha rhythm) with a reduction in pain intensity in the in neurofeedback program and positive dynamics of the main characteristics of the alpha rhythm have been drmonstrated. Inclusion in the treatment program of arthritis biobehavioral approach has reduced the dose of pain medication, so reducing aggression of pharmacotherapy.
ASSESSMENT OF THE ADAPTIVE ABILITIES IN JUNIOR SCHOOL STUDENTS USING GAME BIOFEEDBACK TECHNOLOGY
Authors: Danilenko Ye. N. , Jafarova O. A. , Mazhirina K. G. 
Published: June 2020

In this study we selected 3 basic types of the adaptive behavior of the junior school students (n = 80) using a comparative analysis of the psychological and psycho-physiological characteristics in the course of game biofeedback. As a result of training the emotional state of the students normalized and psycho physiological tension decreased. The ADHD and frequently ill students also got a positive outcome after training.
INVESTIGATION OF NEUROPROTECTIVE ACTIVITY THIOPHANE INVOLUTIONAL CHORIORETINAL DEGENERATION IN RATS OXYS
Authors: Zhdankina A. A. , Kon G. A. , Plotnikov M. B. , Varakuta Ye. Yu. , Logvinov S. V. , Prosenko A. Ye. , Kolosova N. G. 
Published: June 2020

The method of spontaneous and induced luminol -dependent chemiluminescence in homogenates of rat retinas OXYS registered increase in the generation of free radicals against decrease in total antioxidant activity. With the ultra-microscopic and quantitative analysis revealed degenerative retinal neurons rats OXYS: the percentage increase in neurosensory cells with pyknosis of nuclei, hyperchromatic piknomorfnyh associative neurons and ganglion n eurons that have been modified on a light and dark type. Thiophane, limiting free radical reactions in the retina and protects retinal neurons from damage.
INFLUENCE OF COMPOSITION OF POLYUNSATURATED FATTY ACIDS ON MICROVISCOSITY OF THE MEMBRANE OF ERYTHROCYTES OF THE NAVEL OF THE BLOOD AT HERPES INFECTION CONTAMINATIONS
Authors: Isutina N. A. 
Published: June 2020

The method of gas-liquid chromatography investigates composition of polyunsaturated fatty acids of membrane of erythrocytes, discharged of navel bloods neonatal from mothers who have transferred in the season gestation exacerbation herpes of an infection contamination and his influence on microviscosity of membrane. Essential infringements of data exchange of bonds in navel bloods neonatal with an exacerbation herpes infection contaminations (antiserum capacity IgG to virus of simple herpes of 1 type 1 : 12 800) which show deficiency essential ω-3 acids at simultaneous augmentation of the precursor proinflammatory eicosanoid ω-6 arachidonic acids, promoting augmentation of relative microviscosity of membrane of erythrocytes that will be one of probable causes of development of hypoxia are found.
PREVENTION OF ERYSIPELAS IN THE EARLY POSTOPERATIVE PERIOD AFTER THE IMPOSITION MIKROLIMFOVEIN ANASTOMOSIS IN PATIENTS AFTER BREAST CANCER LYMPHEDEMA
Authors: Smagin M. A. , Lubarsky M. S. , Shumkov O. A. , Nimaev V. V. , Poveshenko O. V. 
Published: June 2020

The aim of work is valuation of the effectiveness of autologous lymphocytes activated by complex of cytokines to prevent erysipelas of patients with after breast cancer syndrome.The estimate of influence of activated autologous lymphocytes to erysipelas. The treatment results of 128 patients with secondary lymphedema of the upper limb II–III stage after curative treatment of breast cancer are included in the work.Activated roncoleukin auto lymphocytes injections were performed in the forearm of the affected limb to the main group’s patients.17.4% faces relapses were recorded in the comparison group. while the group with the usage of activated roncoleukin autologous lymphocytes had achieved significant reductions in recurrent of erysipelas up to 5%.
DEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID
Authors: Tyurenkov I. N. , Perfilova V. N. , Mikhailova L. I. , Zhakupova G. A. , Lebedeva S. A. 
Published: June 2020

The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled by replacing the drinking water of 1.8% sodium chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.
ENTROPY METHODS IN ANALYSIS OF BIOLOGICAL SYSTEMS
Authors: Berestneva O. G. , Pekker Ya. S. , Murzina S. S. 
Published: June 2020

The adaptation of people to new production environment are often influenced by very unusual, excessive and harsh environmental factors, genetically inadequate to its nature. Human adaptation to the new production conditions can be summarized as a set of social and biological properties and characteristics needed to sustain the existence of the human body in a particular ecological environment.It is necessary under the new conditions to achieve harmony of human interaction with the physical environment of their lives, adequate human nature. In addressing this fundamental problem of the primary role belongs to biomedical science, which should not so much to predict the appearance of the disease, how much help to preserve and improve the health of population. At the same time beco­ming increasingly clear that solving this problem adaptation theory plays a crucial role.Adaptive features appear only in real life. It is in particular natural or artificial habitat capabilities of the body, when the survival and life require maximum mobilization and stress its potential adaptive capacity. Consequently, the property adaptation of living systems is, in fact, a measure of individual health.An approach based on entropy methods for modeling complex systems, seems to be the most promising for integrated assessment of biological systems.
THE PROCESSING AND TRANSMISSION FOR MEDICAL STATISTICS BASED ON THE INTERNATIONAL STANDARD ISO 13606
Authors: Kopanitsa G. D. 
Published: June 2020

A possibility to unite different healthcare providers in one network was investigated and proved. We developed solution based on ISO 13606 archetype model and service oriented architecture to enable an exchange of semantically meaningful medical data within a network of healthcare providers. Application of a data model of the ISO 13606 standard for data modeling and XML data transformation allowed organizing data exchange in the regional healthcare network.
APPLICATION OF A BIODEGRADABLE MATERIAL FOR BONE REPLACEMENT IN TRAUMATOLOGY
Authors: Druzhinina T. V. , Trofimov K. V. , Naydanov V. F. , Rostovzev A. V. , Burkov D. V. , Zhulyabin A. V. , Isupov A. A. , Verevin A. V. 
Published: June 2020

20 men (medium age (31.5 ± 13.5) years) were studied. All patients underwent arthroscopic auditing plastic anterior cruciate ligament of the knee. Osteoregeneration dynamics were determined by biochemical testing of blood serum and X-ray computed tomography (CT) of the fracture in 1–4 months after surgery. As a result, an estimation of the bone tissue reparative regeneration according to CT data in 10 patients with a defect of the patella, treated with the material is provided. The obtained results of the clinical study indicate the reparative effect of the biodegradable material for bone replacing on bone regeneration