bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO-032: Targeting the KRAS dimerization interface enhances T-cell mediated anti-tumor response in vivo
Authors: Khan Imran , Lefler Julia , Marelia Catherine , Zuberi Mariyam , Denbaum Eric , Koide Akiko , Timmers Cynthia , Ostrowski Michael , Koide Shohei , O’Bryan John 
Published: November 2020

Abstract
RAS is the most frequently mutated human oncogene and about 20% of all human cancers harbor mutations in one of three RAS oncogenes (K, N and H-RAS) with pancreatic cancers harboring RAS mutations in &gt;90% of tumors. Therapeutically targeting RAS has been highly challenging and other than allele specific KRAS (G12C) inhibitors, no direct RAS inhibitor has been approved for clinical trial. However, KRAS (G12C) mutations are less abundant in some cancers like pancreatic cancer, thus there remains an unmet need for inhibitors that target the more common RAS mutants. This demand devising novel strategies to identify new approaches to inhibit RAS. Previously, we developed the H/KRAS-specific monobody called NS1 that allosterically inhibit RAS-mediated signaling by targeting the α4-α5 dimerization interface. When used as a genetically encoded intracellular reagent, NS1 inhibited the growth of H/KRAS-mutant human tumor lines both in vitro and in xenograft tumor models. However, these tumor models lack a functional immune system. Here, we evaluated the potency of targeting KRAS dimerization interface with NS1 in an immune-competent murine model of pancreatic cancer. Although human and murine KRAS differ by a single amino acid [Asp (D) to Glu (E)] at position 132 in the NS1 binding region of the allosteric lobe, NS1 bound similarly to human and murine KRAS both in vitro and in vivo. Furthermore, NS1 expression inhibited ERK-MAPK activation, proliferation and anchorage-independent growth of engineered KPC cells derived from pancreatic tumor in the KPC genetic mouse model. Finally, when these engineered KPC cells were injected orthotopically in immune-competent C57/B6 mice, we observed a dramatic decrease in tumor growth kinetics and tumor burden in NS1 expressing cohorts. Similarly, NS1 expression resulted in decreased ERK-MAPK activation and increased apoptosis. NS1 expressing tumors were characterized by increased infiltration of helper CD4+ T cells and macrophage. Thus, inhibition of mutant KRAS by NS1 results in an enhanced anti-tumor immune response in a syngeneic model for pancreatic cancer. These results establish that targeting α4-α5 dimerization interface of RAS can be a viable therapeutic option for targeting KRAS-mutant pancreatic cancer.
Citation Format: Imran Khan, Julia Lefler, Catherine Marelia, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Cynthia Timmers, Michael Ostrowski, Shohei Koide, John O’Bryan. Targeting the KRAS dimerization interface enhances T-cell mediated anti-tumor response in vivo [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-032.
Abstract PO-036: Defining the role of chromatin remodelers in pancreatic cancer
Authors: Ferguson Lesley Paige , Gatchalian Jovylyn , Lytle Nikki , Rajbhandari Nirakar , McDermott Matthew , Chambers Kendall , Rosenthal Sara Brin , Schuerch Christian , Zlobec Inti , Wartenberg Marten , Diamantis Eva , Galván José A. , Albini Sonia , Puri Lorenzo , Bruneau Benoit , Lowy Andrew M. , Hargreaves Diana , Reya Tannishtha 
Published: November 2020

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a disease characterized by aggressive metastasis and resistance to therapy, making clinical management a significant challenge. We have focused on understanding how pancreatic cancer may be influenced by developmental and stem cell signals as they are often aberrantly re-activated during cancer progression. Given the central role for epigenetic regulation in development, we hypothesized that epigenetic factors may be required to sustain the self-renewal and aggressive nature of pancreatic cancer cells. To this end, we carried out a functional screen and identified Smarcd3, a component of the SWI/SNF (Baf) nucleosome remodeling complex, as a novel functional dependency in PDAC. SWI/SNF coordinates context-specific gene regulation in development and is frequently dysregulated in cancer. However, Smarcd3 has not been linked to functions in PDAC and represents a new epigenetic mediator of tumorigenesis. We found that Smarcd3 was uniquely up-regulated in PDAC stem cells and was required for the in vivo propagation of mouse and patient-derived tumors. Further using integrated RNA-seq, ChIP-seq, and network analysis we found that Smarcd3 regulates global SWI/SNF binding and histone acetylation, driving the epigenetic regulation of core cell fate and metabolic programs. Specifically, we found that Smarcd3 regulated genes converging on the mevalonate pathway and ultimately cholesterol biosynthesis, which has been directly implicated in stem signaling in PDAC. Collectively, these data identify Smarcd3 as a critical novel dependency and epigenetic regulator of pancreatic cancer metabolism.
Citation Format: Lesley Paige Ferguson, Jovylyn Gatchalian, Nikki Lytle, Nirakar Rajbhandari, Matthew McDermott, Kendall Chambers, Sara Brin Rosenthal, Christian Schuerch, Inti Zlobec, Marten Wartenberg, Eva Diamantis, José A. Galván, Sonia Albini, Lorenzo Puri, Benoit Bruneau, Andrew M. Lowy, Diana Hargreaves, Tannishtha Reya. Defining the role of chromatin remodelers in pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-036.
Traduzir a poesia brasileira
Authors: Xudong Hu 
Published: November 2020

É constrangedor confessar, mas antes de eu ir ao Brasil em 2003, ignorava por completo a riqueza da poesia modernista desse grande país. Na realidade, eu não era o único. O desconhecimento total da poesia brasileira entre os poetas contemporâneos chineses ainda é uma situação comum. Antes de eu deixar o Brasil em 2005, além de Vinícius de Moraes, eu também havia traduzido alguns poemas de Manuel Bandeira, Carlos Drummond de Andrade, Mário Quintana, Paulo Leminski, Ana Cristina César. Contudo, logo descobri minha meta de tradução: João Cabral de Melo Neto, mestre da poesia modernista brasileira.
Poemas chineses
Authors: Marsicano Alberto , Chih Chiu Yi , Si-Yuan Chiu 
Published: November 2020

Apresentamos aqui três versões de dois poemas de Li Po. Durante o trabalho, deparamo-nos com a delicada tarefa de transpor a estrutura sintética dos poemas, o que nos levou à extrema concisão no processo de tradução. A visualidade ideogrâmica e a riqueza imagética da poesia chinesa foram aspectos fundamentais que exigiram bastante cuidado de nossa parte, incluindo o próprio universo cifrado e simbólico dos poemas.
Alberto Marsicano
Authors: Milton John 
Published: November 2020

"Eu adorava tomar uma cerveja com Marsicano e escutar suas experiências mirabolantes. Ele não está mais conosco, mas sua wit de raconteur pode ser vista nas Crônicas Marsicanas (L&PM 2007) e também na entrevista que ele deu ao programa da TV Cultura, Provocações, em 2012."Homenagem de John Milton ao músico, tradutor, poeta e raconteur Alberto Marsicano.
Association Between Hospital Debriefing Practices With Adherence to Resuscitation Process Measures and Outcomes for In-Hospital Cardiac Arrest
Authors: Malik Ali O. , Nallamothu Brahmajee K. , Trumpower Brad , Kennedy Marci , Krein Sarah L. , Chinnakondepalli Khaja M. , Hejjaji Vittal , Chan Paul S. 
Published: November 2020

Background
Identifying actionable resuscitation practices that vary across hospitals could improve adherence to process measures or outcomes after in-hospital cardiac arrest (IHCA). We sought to examine whether hospital debriefing frequency after IHCA varies across hospitals and whether hospitals which routinely perform debriefing have higher rates of process-of-care compliance or survival.

Methods
We conducted a nationwide survey of hospital resuscitation practices in April of 2018, which were then linked to data from the Get With The Guidelines–Resuscitation national registry for IHCA. Hospitals were categorized according to their reported frequency of debriefing immediately after IHCA; rarely (0%–20% of all IHCA cases), occasionally (21%–80%), and frequently (81%–100%). Hospital-level rates of timely defibrillation (≤2 minutes), epinephrine administration (≤5 minutes), survival to discharge, return of spontaneous circulation, and neurologically intact survival were comparted for patients with IHCA from 2015 to 2017.

Results

Overall, there were 193 hospitals comprising 44 477 IHCA events. Mean patient age was 65±16, 41% were females, and 68% were of White race. Across hospitals, 84 (43.5%) rarely performed debriefings immediately after an IHCA, 82 (42.5%) performed debriefing sessions occasionally, and 27 (14.0%) performed debriefing frequently. There was no association between higher reported debriefing frequency and hospital rates of timely defibrillation and epinephrine administration. Mean hospital rates of risk-standardized survival to discharge were similar across debriefing frequency groups (rarely 25.6%; occasionally 26.0%; frequently 25.2%,
P
=0.72), as were hospital rates of risk-adjusted return of spontaneous circulation (rarely 72.2%; occasionally 73.0%; frequently 70.0%,
P
=0.06) and neurologically intact survival (rarely 21.9%, occasionally 22.2%, frequently 21.1%,
P
=0.75).

Conclusions
In a large contemporary nationwide quality improvement registry, hospitals varied widely in how often they conducted debriefings immediately after IHCA. However, hospital debriefing frequency was not associated with better adherence to timely delivery of epinephrine or defibrillation or higher rates of IHCA survival.
A Response to Joseph M. Lear, ‘Liturgy with Ruth: Immigration and the Problem of Anti-Eucharist’
Authors: Casarez Tommy 
Published: November 2020

Abstract
In this response to Joseph Lear, Tommy Casarez praises Lear’s use of the phrase, ‘anti-eucharist’, and his claim that we live in an anti-eucharist culture, or something akin to Madonna’s material world. Noting the significance of food and common meals in Scripture, Casarez points out that Ruth is not only and not primarily a recipient but also a contributor. Lear is commended for his description of a space-making ethic, with the eucharist serving as a space-making event that essentially defines the shape and character of the Christian way of life.
Towards a Pentecostal, Postcolonial Reading of the New Testament
Authors: Low U-Wen 
Published: November 2020

Abstract
Although both Pentecostalism and postcolonial thought seem to stand poles apart, they have a remarkable amount in common. Early Pentecostal revivals largely sprang from ‘subaltern groups’, people groups marginalized by colonial power and dominant groups. Bringing together Pentecostalism and postcolonial thought is a complex task, but one that promises to yield positive results. Exploring the text through the twin lenses of postcolonial thought and the distinctive Pentecostal emphasis on pneumatology results in a fresh hermeneutical perspective: that the Holy Spirit might be understood as a postcolonial agent of change that empowers those who have experienced the baptism of the Holy Spirit to resist dominant structures of oppression. The New Testament text can therefore be understood as a ‘hidden transcript’, a disguised work of resistance composed by subaltern groups against dominance and oppression. This article therefore seeks to explore the theoretical underpinnings of a ‘Pentecostal, postcolonial reading’ of the New Testament.
Glory beyond the Camp
Authors: Redick Caroline R. 
Published: November 2020

Abstract
This article investigates whether the charismatic renewal’s Via Spiritus, with its emphasis on festival, joy, and divine empowerment, has eclipsed the Via Crucis, with its somatic pedagogy of suffering and renunciation. It explores this dynamic by contrasting two practices: the medieval Catholic pilgrimage and charismatic revival-seeking. Through exploring the overlaps between these two practices, the revival is interpreted as a liminal journey, a festival of grace, and a ritual of renunciation. At the same time, contrasting the penitential ritual of pilgrimage and revivals reveals a deficit of repentance in charismatic practice and theology.
Mission in the Middle
Authors: Álvarez Miguel 
Published: November 2020

Abstract
Miguel Álvarez, a native of Honduras, explores how mission theology and the contextual implementation of Missio Dei is impacted by Latino hermeneutics. As a foundation, the article compares the North American and Latin American approaches to missiology. It shows how mission as an act of benevolence in the practice of faith differs from mission as a total commitment to the gospel in the execution of the Great Commission. Álvarez contends that because of their context of service, Latinos interpret God’s mission based on a paradigm that favors the poor and disenfranchised of society, and he argues that the ministry of Jesus Christ followed the same paradigm. This Latino perspective on mission helps to explain the current revival that is taken place in the Global South today.
Herd Agency
Authors: Bumochir Dulam , Ichinkhorloo Byambabaatar , Ahearn Ariell 
Published: November 2020

Abstract
In this article, we draw upon ethnographic fieldwork conducted in Mongolia and China to develop understandings of herd–herder (mal–malchin) relations further. We focus primarily on horse-herding practices and related divisions of labour, and the three concepts of herd intuition (zön), serenity (taa) and fortune (buyan, khishig, zaya), to present additional interpretations of human–animal relations in Mongolia. Through this exploration, we develop the concept of herd agency and examine how it relates to specific horse-herding knowledge and techniques, as well as the cosmological significance of human–animal relations. All three concepts reveal the importance of cosmological agents with herd–herder relations. We conclude by emphasising the changing nature and politics of human–animal relations in these regions.
Property Relations of Mongolian Women during the Qing Period
Authors: Chuluunbaatar Udaanjargal , Rogers Leland Liu 
Published: November 2020

Abstract
This study considers the historical importance of the dowry, or inǰe, in outer Mongolia during the Qing period (1636–1911), focusing on the developments of the legal system towards women’s rights over their dowry using archival legal case documents from the Mongolian archives. Previous studies argue that the dowry system was of little importance among the steppe populations; however, the Mongolian archival documents make it clear that the dowry played a very important role in society for establishing prestige and for acquisition of property for families during the Qing period. They also show that the courts in Mongolia consistently ruled in favour of women, particularly in the case of their ownership and compensation for dowry livestock during divorce cases, including livestock born from dowry livestock, demonstrating that pre-modern Mongol women were considered autonomous social agents with distinct personal rights, and not thought of as property.
Re-reading Armenian Modernity in Madt‘ēos Mamurian’s English Letters
Authors: Aktokmakyan Maral 
Published: November 2020

Abstract
This article moves to examine Madt‘ēos Mamurian’s English Letters or the Destiny of an Armenian alongside issues of national consciousness and the modern political subject. Focusing on the narrative style and structure that allowed the author to problematize and cultivate the idea of reawakening the Armenian nation and individual as a political animal, the article claims to bring in the notion of the strange, stranger and the uncanny, as the operating tools in Mamurian’s engagement with the modern in a late nineteenth century Ottoman-Armenian context.
Medieval contexts and modern realities of a Genocide-survivor artwork
Authors: Grigoryan Savary Gohar 
Published: November 2020

Abstract
This article is a critical review of Heghnar Watenpaugh’s monograph The Missing Pages, which traces the history of the thirteenth-century Zeytun Gospels from its creation to the 2010s, when several of the manuscript’s illustrated folios became subject to a restitution claim through a lawsuit filed by the Armenian Church against the Getty Museum. It highlights the importance of Watenpaugh’s publication on assembling and clarifying the impressive itinerary of the Zeytun Gospels, the manuscript’s sociocultural functions, as well as the historiographic research on Cilician miniature painting conducted by the author in the framework of this book. In the present article, several issues raised in the book are critically explored from different angles, expressing a partial or significant difference of opinion when it comes to some of the interpretations and contextualizations proposed by Watenpaugh. These include: Watenpaugh’s nonexhaustive consideration of the Zeytun Gospels’ colophons, which stand as the most authentic documentations on the manuscript’s history prior to the twentieth century; her tracing of parallel examples of artifacts that survived the Genocide based not on scholarly research but on popular narratives (and on contemporary literary writings); the discussion of bilingual coins minted by the Armenian king Hetum I and the Seljuk sultan Kaykhusraw II as cases of “complex identities of the period”, without delving into these complexities, and, thus, not doing justice to the nuances of the medieval context of their rule; some aspects of the history of scholarship on Cilician miniature painting; and the way Watenpaugh presents two of the most prominent historians of Armenian art, Sirarpie Der Nersessian and Karekin Hovsepian, and their attitudes toward the ownership and acquisition of Armenian cultural heritage by western art institutions, which appear to be less than balanced in The Missing Pages. Finally, some reflections on contemporary exhibition practices of survivor artifacts, whose current locations of preservation are often a consequence of (cultural) genocide and dubious acquisition practices, require clearer and more in-depth presentation, at least as far as the exhibition history of the Zeytun Gospels and its separated folios is concerned.
Creedal Controversies among Armenians in the Seventeenth-Century Ottoman Empire
Authors: Ohanjanyan Anna 
Published: November 2020

Abstract
In the late seventeenth century along the lines of European confession-building and Ottoman sunnitization, the Armenian Apostolic Church initiated the reshaping of its orthodoxy in the face of growing Tridentine Catholicism. Through the contextualization of the polemical writing attributed to the famed Constantinopolitan Armenian erudite Eremia Čʻēlēpi Kʻēōmiwrčean, this article discusses the ways of detecting “bad innovations” in the doctrine and practice of Armenian communities in the Ottoman realms, and the doctrinal instruments used for enforcing “pure faith” towards social disciplining of the Apostolic Armenians.
Leveraging Advanced Practice Providers in an Otolaryngology Practice
Authors: Sharma Nita , Upjohn David , Donald Carrlene , Zoske Katie E. , Aldridge Chelsea L. , Lal Devyani 
Published: November 2020

ObjectiveAdvanced practice providers (APPs) may see patients independently or assist in “collaborative” clinics in otolaryngology practices. Our goal was to redesign the collaborative physician‐APP clinic model to increase patient access, maintain financial sustainability, and optimize patient and staff experience.MethodsThe study was performed in a tertiary care academic rhinology clinic seeing adult patients. The DMAIC framework (define, measure, analyze, improve, control) was used to develop the new model. The process shift between old and new models was analyzed by utilizing a statistical process control chart. Patient and staff surveys were tracked.ResultsThe collaborative physician‐APP model was redesigned into 2 parallel and independently run (“concurrent”) physician and APP clinics. Patient access increased by 38.9% from a mean of 17.9 patients per collaborative clinic (n = 15 days, 269 patients) to 29.3 patients per concurrent clinic (n = 12 days, 352 patients). Medicare reimbursement rate modeling showed the collaborative clinic to operate at a loss of $1341.51 per day, while the concurrent clinic model operated at a $1309.88 gain (200% positive change). Patient and staff experience tracked positively.DiscussionOtolaryngology clinics can become overwhelmed by the volume of empaneled established patients. Traditional collaborative physician‐APP clinics see the same panel of patients together. However, these can be successfully redesigned to a concurrent model. Concurrent clinics improve patient access and provider satisfaction while maintaining patient satisfaction and fiscal performance.Implications for PracticeLeveraging an experienced APP to run a parallel and independent clinic alongside the physician (concurrent clinic model) may improve patient access, financial metrics, and patient/staff experience.
Factors that influence mothers’ prenatal decision to breastfeed in Spain
Authors: Ballesta-Castillejos Ana , Gómez-Salgado Juan , Rodríguez-Almagro Julián , Ortiz-Esquinas Inmaculada , Hernández-Martínez Antonio 
Published: November 2020

Abstract
Background
Parents’ decisions about how to feed their newborns are influenced by multiple factors. Our objective was to identify the factors that can influence the decision to breastfeed.

Methods
Cross-sectional observational online study was conducted in Spain on women who gave birth between 2013 and 2018. The total number of participants was 5671. Data collection was after approval by the ethics committee in 2019. The data were collected retrospectively because the information was obtained from women who were mothers during the years 2013–2018. An online survey was distributed to breastfeeding associations and postpartum groups. Multivariate analysis with binary logistic regression was done to calculate the Adjusted Odds Ratios (aOR). The main result variable was “intention to breastfeed”.

Results
Ninety-seven percent (n = 5531) of women made the decision to breastfeed prior to giving birth. The internet played a role in deciding to breastfeed in 33.7% (n = 2047) of women, while 20.1% (n = 1110) said the same thing about their midwife. We identified five significant factors associated with the mother’s prenatal decision to breastfeed: attending maternal education (aOR 2.10; 95% CI 1.32, 3.34), having two (aOR 0.52; 95% CI 0.28, 0.99) and three children (aOR 0.24; 95% CI 0.10, 0.59), previous breastfeeding experience (aOR 6.99; 95% CI 3.46, 14.10), support from partner (aOR 1.58; 95% CI 1.09,2.28) and having a condition during pregnancy (aOR 0.62; 95% CI 0.43, 0.91).

Conclusions
Factors related with previous breastfeeding experience and education for mothers are decisive when it comes to making the decision to breastfeed. Given the proven influence that partners have in decision-making, it is important for them to be fully involved in the process.