bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Centred Medical Home (PCMH) transitions in western Sydney, Australia: a qualitative study
Authors: Metusela Christine , Usherwood Tim , Lawson Kenny , Angus Lisa , Kmet Walter , Ferdousi Shahana , Reath Jennifer 
Published: April 2020

AbstractBackgroundPatient Centred Medical Homes (PCMHs), increasingly evidenced to provide high quality primary care, are new to Australia. To learn how this promising new healthcare model works in an Australian setting we explored experiences of healthcare providers in outer urban Sydney, where a number of practices are transitioning from traditional Australian general practice models to incorporate elements of PCMH approaches.MethodsWe collected qualitative data from semi-structured interviews with healthcare providers working in a range of transitioning practices and thematically analysed the data. We interviewed 35 participants including general practitioners, practice managers and practice nurses from 25 purposively sampled general practices in western Sydney, Australia, seeking maximal variation in practice size, patient demographics and type of engagement in practice transformation.ResultsInterviewees described PCMH transformation highlighting the importance of whole of practice engagement with a shared vision; key strategies for transformation to PCMH models of care including leadership, training and supportive information technology; structures and processes required to provide team-based, data-driven care; and constraints such as lack of space and the current Australian fee-for-service general practice funding model. They also reported their perceptions of early outcomes of the PCMH model of care, describing enhanced patient and staff satisfaction and also noting fewer hospital admissions, as likely to reduce costs of care.ConclusionsOur study exploring the experience of early adopters of PCMH models of care in Australia, informs the international movement towards PCMH models of care. Our findings provide guidance for practices considering similar transitions and describe the challenges of such transitions within a fee-for-service payment system.
Readmissions after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy—a national population-based study
Authors: Dranichnikov Paul , Graf Wilhelm , Cashin Peter H. 
Published: April 2020

Abstract
Background
Comprehensive readmission morbidity studies after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are scarce. This study aimed to investigate readmissions and in-hospital morbidity after CRS and HIPEC.

Methods
The national in-hospital patient register was used to identify patients via the HIPEC ICD code JAQ10 2004–2014. Data were retrieved from the index CRS/HIPEC treatment and from all HIPEC-related readmissions within 6 months. Univariate/multivariate logistical analyses were performed to identify risk factors for reinterventions and readmissions.

Results
A total of 519 patients (mean age 56 years) had a mean hospital stay of 27 days. Within 6 months, 150 readmissions for adverse events were observed in 129 patients (25%) with 67 patients requiring an intervention (13%). Totally 179 patients (34%) required a reintervention during the first 6 months with 85 (16%) requiring a reoperation. Of these 179 patients, 83 patients (46%) did not undergo the intervention at the HIPEC centre. Gastric resection was the only independent risk factor for in-hospital intervention, and advanced age for readmission.

Conclusion
Morbidity causing HIPEC-related readmission was higher than expected with almost half of the interventions occurring outside the HIPEC centre. Gastric resection and high age are independent predictors of morbidity and readmission.
A LASSO-derived risk model for long-term mortality in Chinese patients with acute coronary syndrome
Authors: Li Yi-ming , Li Zhuo-lun , Chen Fei , Liu Qi , Peng Yong , Chen Mao 
Published: April 2020

AbstractBackgroundThe formal risk assessment is essential in the management of acute coronary syndrome (ACS). In this study, we develop a risk model for the prediction of 3-year mortality for Chinese ACS patients with machine learning algorithms.MethodsA total of 2174 consecutive patients who underwent angiography with ACS were enrolled. The missing data among baseline characteristics were imputed using the MissForest algorithm based on random forest method. In model development, a least absolute shrinkage and selection operator (LASSO) derived Cox regression with internal tenfold cross-validation was used to identify the predictors for 3-year mortality. The clinical performance was assessed with decision curve analysis.ResultsThe average follow-up period was 27.82 ± 13.73 months; during the 3 years of follow up, 193 patients died (mortality rate 8.88%). The Kaplan–Meier estimate of 3-year mortality was 0.91 (95% confidence interval (CI): 0.890.92). After feature selection, 6 predictors were identified: Age,” “Creatinine,” “Hemoglobin,” “Platelets,” “aspartate transaminase (AST)” and “left ventricular ejection fraction (LVEF)”. At tenfold internal validation, our risk model performed well in both discrimination (area under curve (AUC) of receiver operating characteristic (ROC) analysis was 0.768) and calibration (calibration slope was approximately 0.711). As a comparison, the AUC and calibration slope were 0.701 and 0.203 in Global Registry of Acute Coronary Events (GRACE) risk score, respectively. Additionally, the highest net benefit of our model within the entire range of threshold probability for clinical intervention by decision curve analysis demonstrated the superiority of it in daily practice.ConclusionOur study developed a prediction model for 3-year morality in Chinese ACS patients. The methods of missing data imputation and model derivation base on machine learning algorithms improved the ability of prediction. .Trial registrationChiCTR, ChiCTR-OOC-17010433. Registered 17 February 2017–Retrospectively registered
The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function
Authors: Vay Sabine Ulrike , Flitsch Lea Jessica , Rabenstein Monika , Monière Helena , Jakovcevski Igor , Andjus Pavle , Bijelic Dunja , Blaschke Stefan , Walter Helene Luise , Fink Gereon Rudolf , Schroeter Michael , Rueger Maria Adele 
Published: April 2020

Abstract
Background
Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes. The course of microglia activation is complex and depends on signals in the surrounding milieu. Recently, it has been suggested that microglia respond to ion currents, as a way of regulating their activity and function.

Methods and results
Under the hypothesis that HCN and KCNQ/Kv7 channels impact on microglia, we studied primary rat microglia in the presence or absence of specific pharmacological blockade or RNA silencing. Primary microglia expressed the subunits HCN1-4, Kv7.2, Kv7.3, and Kv7.5. The expression of HCN2, as well as Kv7.2 and Kv7.3, varied among different microglia phenotypes. The pharmacological blockade of HCN channels by ZD7288 resulted in cell depolarization with slowly rising intracellular calcium levels, leading to enhanced survival and reduced proliferation rates of resting microglia. Furthermore, ZD7288 treatment, as well as knockdown of HCN2 RNA by small interfering RNA, resulted in an attenuation of later microglia activation—both towards the anti- and pro-inflammatory phenotype. However, HCN channel inhibition enhanced the phagocytic capacity of IL4-stimulated microglia. Blockade of Kv7/KCNQ channel by XE-991 exclusively inhibited the migratory capacity of resting microglia.

Conclusion
These observations suggest that the HCN current contributes to various microglia functions and impacts on the course of microglia activation, while the Kv7/KCNQ channels affect microglia migration. Characterizing the role of HCN channels in microglial functioning may offer new therapeutic approaches for targeted modulation of neuroinflammation as a hallmark of various neurological disorders.
Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model
Authors: Jing Na , Fang Bo , Li Zhe , Tian Ayong 
Published: April 2020

AbstractBackgroundCannabinoid-2 receptor (CB2R) plays an important role in the cascading inflammation following ischemic injury. The toll-like receptors 4 (TLR4)/matrix metalloproteinase 9 (MMP9) signal pathway is involved in blood-brain barrier dysfunction induced by ischemia stroke. The aim of this study is to investigate the roles of exogenous activation of CB2R on attenuating neurological deficit and blood-spinal cord barrier (BSCB) disruption during rat spinal cord ischemia reperfusion (I/R) injury, through modulation of the TLR4/MMP9 axis.MethodsAnimals were intraperitoneally pretreated with TLR4 inhibitor TAK-242, CB2R agonist JWH-133 with or without CB2R antagonist AM630, or equivalent volume of vehicle 1 h before undergoing 14-min occlusion of descending aorta or sham operation. One, two, three, and 7 days after reperfusion, hindlimb locomotor function was evaluated with Basso, Beattie, and Bresnahan (BBB) Locomotor Scale, BSCB integrity was detected by measurement of Evans blue (EB) extravasation and spinal cord edema. The protein expression levels of CB2R, tight junction protein Zonula occluden-1 (ZO-1), TLR4, MMP9, MyD88, NF-κB p65, and NF-κB p-p65 were determined by western blot. The MMP9 activity was analyzed by gelatin zymography. Double immunofluorescence staining was used to identify the perivascular localization of CB2R, TLR4, MMP9, and reactive astrocytes, as well as the colocalization of CB2R, TLR4, and MMP9 with reactive astrocytes.ResultsJWH-133 pretreatment attenuated hindlimb motor functional deficit and BSCB leakage, along with preventing downregulation of ZO-1 and upregulation of TLR4/MMP9, similar to the effects of TAK-242 preconditioning. JWH-133 or TAK-242 pretreatment reduced the perivascular expression of TLR4/MMP9 and reactive astrocytes following injury. JWH-133 pretreatment also downregulated MyD88/NF-κB level, MMP9 activity, and the astrocytic TLR4/MMP9 after I/R injury.ConclusionsExogenous activation of CB2R by JWH-133 attenuated neurological deficit and BSCB disruption after spinal cord I/R injury via inhibition of TLR4/MMP9 expression.
Mechanisms and rejuvenation strategies for aged hematopoietic stem cells
Authors: Li Xia , Zeng Xiangjun , Xu Yulin , Wang Binsheng , Zhao Yanmin , Lai Xiaoyu , Qian Pengxu , Huang He 
Published: April 2020

AbstractHematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability, impaired homing, myeloid-biased differentiation, and other defects in hematopoietic reconstitution function, is a hot topic in stem cell research. Although the number of HSCs increases with age in both mice and humans, the increase cannot compensate for the defects of aged HSCs. Many studies have been performed from various perspectives to illustrate the potential mechanisms of HSC aging; however, the detailed molecular mechanisms remain unclear, blocking further exploration of aged HSC rejuvenation. To determine how aged HSC defects occur, we provide an overview of differences in the hallmarks, signaling pathways, and epigenetics of young and aged HSCs as well as of the bone marrow niche wherein HSCs reside. Notably, we summarize the very recent studies which dissect HSC aging at the single-cell level. Furthermore, we review the promising strategies for rejuvenating aged HSC functions. Considering that the incidence of many hematological malignancies is strongly associated with age, our HSC aging review delineates the association between functional changes and molecular mechanisms and may have significant clinical relevance.
Defining and predicting service utilisation in young adulthood following childhood treatment of an eating disorder
Authors: McClelland Jessica , Simic Mima , Schmidt Ulrike , Koskina Antonia , Stewart Catherine 
Published: April 2020

Background
Eating disorder services are often separated into child and adolescent eating disorder services (CAEDSs) and adult eating disorder services (AEDSs). Most patients in CAEDSs present with first-episode illness of short duration, which with appropriate treatment, have a good prognosis. However, some individuals receive further treatment as adults. Little is known about service utilisation in adulthood following childhood/adolescent treatment of an eating disorder.

Aims
This study aims (a) to estimate the proportion of patients in a CAEDS who use mental health services as young adults, (b) to delineate service utilisation following treatment in CAEDSs and (c) to identify factors in CAEDSs that predict service utilisation in young adulthood.

Method
A consecutive cohort of 322 patients (aged 13–17 years) seen in a CAEDS in the UK over a 5-year period were included in this audit. Data regarding their use of UK-wide adult mental health services as young adults (i.e. when aged 18–25) were extracted from local and national hospital records.

Results
A total of 68.3% of CAEDS patients received no mental health treatment as young adults. Although 13% of people seen in a CAEDS had brief eating disorder treatment as young adults, 10% received longer/or more intensive eating disorder treatment. Overall, 10.8% transitioned directly to an AEDS and 7.6% were re-referred following discharge from CAEDS. In our sample, older age and increased use of CAEDSs predicted increased eating disorder treatment in young adulthood.

Conclusions
Our results indicate that most people seen in CAEDSs do not receive further mental health treatment as young adults. Several features in CAEDSs distinguish mental health service utilisation in young adulthood, which were identified clinically and could be targeted during treatment.
Defining Undertreatment and Overtreatment in Older Adults With Cancer: A Scoping Literature Review
Authors: DuMontier Clark , Loh Kah Poh , Bain Paul A. , Silliman Rebecca A. , Hshieh Tammy , Abel Gregory A. , Djulbegovic Benjamin , Driver Jane A. , Dale William 
Published: April 2020

PURPOSE The terms undertreatment and overtreatment are often used to describe inappropriate management of older adults with cancer. We conducted a comprehensive scoping review of the literature to clarify the meanings behind the use of the terms. METHODS We searched PubMed (National Center for Biotechnology Information), Embase (Elsevier), and CINAHL (EBSCO) for titles and abstracts that included the terms undertreatment or overtreatment with regard to older adults with cancer. We included all types of articles, cancer types, and treatments. Definitions of undertreatment and overtreatment were extracted, and categories underlying these definitions were derived through qualitative analysis. Within a random subset of articles, C.D. and K.P.L. independently performed this analysis to determine final categories and then independently assigned these categories to assess inter-rater reliability. RESULTS Articles using the terms undertreatment (n = 236), overtreatment (n = 71), or both (n = 51) met criteria for inclusion in our review (n = 256). Only 14 articles (5.5%) explicitly provided formal definitions; for the remaining, we inferred the implicit definitions from the terms’ surrounding context. There was substantial agreement (κ = 0.81) between C.D. and K.P.L. in independently assigning categories of definitions within a random subset of 50 articles. Undertreatment most commonly implied less than recommended therapy (148; 62.7%) or less than recommended therapy associated with worse outcomes (88; 37.3%). Overtreatment most commonly implied intensive treatment of an older adult in whom the harms of treatment outweigh the benefits (38; 53.5%) or intensive treatment of a cancer not expected to affect an older adult in his/her remaining lifetime (33; 46.5%). CONCLUSION Undertreatment and overtreatment of older adults with cancer are imprecisely defined concepts. We propose new, more rigorous definitions that account for both oncologic factors and geriatric domains.
The Use of Aviation Biofuels as an Airport Environmental Sustainability Measure: The Case of Oslo Gardermoen Airport
Authors: Baxter Glenn 
Published: April 2020

<p>In recent times, there has been a growing trend by airports and airlines to use aviation biofuel as an environment sustainability measure. Using an instrumental qualitative case study research design, this paper examines the evolution of sustainable aviation fuels at Oslo Airport Gardermoen. Oslo Airport Gardermoen was the first airport in the world to offer the first airport in the world to offer aviation biofuels to all airlines in 2016. The qualitative data were examined by document analysis. The study found that the use of sustainable aviation biofuels has delivered tangible environmental benefits to Oslo Gardermoen Airport. The usage of aviation biofuels has enabled the airport, and the airlines using sustainable aviation biofuels, to reduce their greenhouse gases by 10-15%. Also, as part of Norway’s efforts to reduce greenhouse gas emissions, the Norwegian Government have mandated that the aviation fuel industry must mix 0.5% advanced biofuel into jet fuel from 2020 onwards. Norway’s Ministry of Climate and Environment’s goal is that by 2030, 30% of the airline fuel will be sustainable in nature and will have a positive climate effect. Avinor, the operator of Norway’s airports, has a goal that by 2030, 30 % of aviation fuel supplied in Norway should be sustainable biofuel – this follows the Norwegian government’s mandate.</p>
Sytuacja dydaktyczna z perspektywy kompetencji komunikacyjnych nauczycieli akademickich
Authors: Jakubczak-Chodźko Magdalena 
Published: April 2020

Jakubczak-Chodźko Magdalena, Sytuacja dydaktyczna z perspektywy kompetencji komunikacyjnych nauczycieli akademickich [The didactic situation from the perspective of academic teacher communication skills]. Kultura – Społeczeństwo – Edukacja nr 2(14) 2018, Poznań 2018, pp. 111–117, Adam Mickiewicz University Press. ISSN 2300-0422. DOI 10.14746/kse.2018.14.9.
This article shows a mode of perception of the relevant didactic situation from the perspective of teacher-held communicatio skills. Using the analysis of rationality, presented are new areas of perception of teacher competence. In addition, with the aid of the approach presented by Jürgen Habermas, it was possible to analyse the significance of communication skills as key in the teaching profession.
Morphometry of inland Common TernsSterna hirundoin Croatia and Slovenia
Authors: Kralj Jelena , Martinović Miloš , Tome Davorin , Jurinović Luka , Galov Ana , Svetličić Ida 
Published: April 2020

AbstractMorphometric data on Common Terns breeding in Croatia and Slovenia are presented herewith for the first time. 130 breeding adult Common TernsSterna hirundowere measured between 2016 and 2019 along the Sava and Drava Rivers. Sex was determined for 53 birds: 22 males and 31 females. Significant sexual differences were found for head and bill length, length of bill to skull, and bill depth. Croatian and Slovenian terns had slightly shorter wings and tails compared to birds from the Netherlands, Germany and England and were lighter than birds from Germany and Italy. Head, bill and tarsus lengths were similar to those in north European populations. Contrary to results from Scotland, in our studied population, birds with head and bill lengths >79.0 mm could not be sexed as males reliably.
Sustained Visual Priming Effects Can Emerge from Attentional Oscillation and Temporal Expectation
Authors: Wang Muzhi , Huang Yan , Luo Huan , Zhang Hang 
Published: April 2020

Priming refers to the influence that a previously encountered object exerts on future responses to similar objects. For many years, visual priming has been known as a facilitation and sometimes an inhibition effect that lasts for an extended period of time. It contrasts with the recent finding of an oscillated priming effect where facilitation and inhibition alternate over time periodically. Here we developed a computational model of visual priming that combines rhythmic sampling of the environment (attentional oscillation) with active preparation for future events (temporal expectation). Counterintuitively, it shows that both the sustained and oscillated priming effects can emerge from an interaction between attentional oscillation and temporal expectation. The interaction also leads to novel predictions, such as the change of visual priming effects with temporal expectation and attentional oscillation. Reanalysis of two published datasets and the results of two new experiments of visual priming tasks with male and female human participants provide support for the model's relevance to human behavior. More generally, our model offers a new perspective that may unify the increasing findings of behavioral and neural oscillations with the classic findings in visual perception and attention.SIGNIFICANCE STATEMENTThere is increasing behavioral and neural evidence that visual attention is a periodic process that sequentially samples different alternatives in the theta frequency range. It contrasts with the classic findings of sustained facilitatory or inhibitory attention effects. How can an oscillatory perceptual process give rise to sustained attention effects? Here we make this connection by proposing a computational model for a “fruit fly” visual priming task and showing both the sustained and oscillated priming effects can have the same origin: an interaction between rhythmic sampling of the environment and active preparation for future events. One unique contribution of our model is to predict how temporal contexts affects priming. It also opens up the possibility of reinterpreting other attention-related classic phenomena.