bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple-negative breast cancer: Epidemiology, characteristics, and survival in a Lebanese cohort
Authors: Ghosn M. , Hajj C. , Nasr F. , El Karak F. , Abadjian G. , Kattan J. , Chahine G. 
Published: August 2020

e22228 Background: Breast cancer (BC) is the most common malignancy in women in Lebanon. Triple negative (TN) phenotype is known to be associated with an increased likelihood of recurrence and death. The purpose of this study is to determine the incidence, characteristics and survival of TN BC patients in a Medical Oncology department in a University Hospital in Lebanon. Methods: We retrospectively reviewed the pathology of all women with breast cancer that were seen in our institution between 1997 and 2008. TN BC patients (pts) were defined as those that were negative for all 3 receptors (estrogen, progesterone and HER2neu on immunohistochemistry). Pts' characteristics and survival of TN women were analyzed. Results: Of the 1599 breast cancer pts, 155 (9.7%) had a triple negative phenotype. Median age was 52 years. A positive family history of breast/ovarian cancer was found in 15 pts (10%). Pathology studies showed: invasive ductal carcinoma component in 138 pts (89%), pure medullary carcinoma in 7 pts (5%), pure invasive lobular carcinoma in 6 pts (4%), pure mucinous carcinoma in 3 pts (2%) and epidermoid carcinoma in 1 pt (1%). A grade III was found in 98 of specimens (63%). Twenty-six pts (17%) presented with stage I, 73 (47%) with stage II, 37 (24%) with stage III and 19 (12%) with stage IV. Twelve percent had inflammatory breast cancer. After a median follow up of 17 months (mths), 43 pts had relapsed (5 stage I, 18 stage II and 20 stage III). The most common sites of relapse were brain (in 20 % of cases), lungs (in 20% of cases) and bone (in 11% of cases). Five- year disease free survival and 5-year overall survival were respectively 75% and 88% for stage I, 58% and 72% for stage II and 40% and 63% for stage III. Adjuvant therapy was administered to 96% of pts among which a taxane-based regimen was used in 38% of cases . Median survival for stage IV was 19 mths with a first line taxane-based regimen used in 50% of cases. Conclusions: The incidence of TN BC in Lebanon is similar to that described in the literature. It has an aggressive course. Focus on understanding the biology of this particular BC subtype is essential for determining targets for future therapeutic options. No significant financial relationships to disclose.
A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
Authors: Miller V. A. , Das A. , Rossi M. 
Published: August 2020

LBA8002 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
Phase III, randomized, double-blind study of elesclomol and paclitaxel versus paclitaxel alone in stage IV metastatic melanoma (MM)
Authors: Hauschild A. , Eggermont A. M. , Jacobson E. , O'Day S. J. 
Published: August 2020

LBA9012 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
One-year test-retest reliability of ten vision tests in Canadian athletes
Authors: Aloosh Mehdi , Leclerc Suzanne , Long Stephanie , Zhong Guowei , Brophy James M. , Schuster Tibor , Steele Russell , Shrier Ian 
Published: August 2020

Background: Vision tests are used in concussion management and baseline testing. Concussions, however, often occur months after baseline testing and reliability studies generally examine intervals limited to days or one week. Our objective was to determine the one-year test-retest reliability of these tests. Methods: We assessed one-year test-retest reliability of ten vision tests in elite Canadian athletes followed by the Institut National du Sport du Quebec. We included athletes who completed two baseline (preseason) annual evaluations by one clinician within 365±30 days. We excluded athletes with any concussion or vision training in between the annual evaluations or presented with any factor that is believed to affect the tests (e.g. migraines). Data were collected from clinical charts. We evaluated test-retest reliability using Intraclass Correlation Coefficient (ICC) and 95% limits of agreement (LoA). Results: We examined nine female and seven male athletes with a mean age of 22.7 (SD 4.5) years. Among the vision tests, we observed excellent test-retest reliability in Positive Fusional Vergence at 30cm (ICC=0.93) but this dropped to 0.53 when an outlier was excluded in a sensitivity analysis. There was good to moderate reliability in Negative Fusional Vergence at 30cm (ICC=0.78), Phoria at 30cm (ICC=0.68), Near Point of Convergence break (ICC=0.65) and Saccades (ICC=0.61). The ICC for Positive Fusional Vergence at 3m (ICC=0.56) also decreased to 0.21 after removing one outlier. We found poor reliability in Near Point of Convergence (ICC=0.47), Gross Stereoscopic Acuity (ICC=0.03) and Negative Fusional Vergence at 3m (ICC=0.0). ICC for Phoria at 3m was not appropriate because scores were identical in 14/16 athletes. 95% LoA of the majority of tests were ±40% to ±90%. Conclusions: Five tests had good to moderate one-year test-retest reliability. The remaining tests had poor reliability. The tests would therefore be useful only if concussion has a moderate-large effect on scores.
Post-stroke fatigue: a scoping review
Authors: Aali Ghazaleh , Drummond Avril , das Nair Roshan , Shokraneh Farhad 
Published: August 2020

Background: Post-stroke fatigue (PSF) is one of the most common and frustrating outcomes of stroke. It has a high prevalence and it can persist for many years after stroke. PSF itself contributes to a wider range of undesirable outcomes that affect all aspects of daily life. The aim of this review was to identify and summarise the most recent research on PSF, in order to update the evidence base.Methods: We updated an existing review (Hinkleet al. 2017) systematically searching CINAHL, MEDLINE, PsycINFO, and PubMed to cover new research studies between 1stMarch 2016 and the search date (19thJanuary 2020). We included interventional and observational research, and clinical practice guidelines that were not covered in the original review. After duplicate removal in EndNote, two reviewers screened the search results in Rayyan, and data from eligible full texts were extracted onto an Excel spreadsheet. Finally, we used RobotReviewer and a human reviewer to assess the risk of bias of randomised trials for this scoping review.Results: We identified 45 records for 30 studies (14 observational, 10 interventional studies, and 6 guidelines). Apart from one, the interventional studies were single-centred, had high risk of bias and small sample size (median 50). They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reported the factors related to PSF including co-morbidities, depression and anxiety, quality of life, activities of daily living, stroke severity, medication use and polypharmacy, polymorphism, pain, apathy, limb heaviness, neuroticism, mobility, and thyroid-stimulating hormone. Guidelines either did not report on PSF or, when reported, their recommendations were supported by little or low level of evidence.Conclusion: Although we identified a number of recent studies which have added to our current knowledge on PSF, none are robust enough to change current clinical practice.
Citations and metrics of journals discontinued from Scopus for publication concerns: the GhoS(t)copus Project
Authors: Cortegiani Andrea , Ippolito Mariachiara , Ingoglia Giulia , Manca Andrea , Cugusi Lucia , Severin Anna , Strinzel Michaela , Panzarella Vera , Campisi Giuseppina , Manoj Lalu , Gregoretti Cesare , Einav Sharon , Moher David , Giarratano Antonino 
Published: August 2020

Background: Scopus is a leading bibliometric database. It contains a large part of the articles cited in peer-reviewed publications. The journals included in Scopus are periodically re-evaluated to ensure they meet indexing criteria and some journals might be discontinued for 'publication concerns'. Previously published articles may remain indexed and can be cited. Their metrics have yet to be studied. This study aimed to evaluate the main features and metrics of journals discontinued from Scopus for publication concerns, before and after their discontinuation, and to determine the extent of predatory journals among the discontinued journals. Methods: We surveyed the list of discontinued journals from Scopus (July 2019). Data regarding metrics, citations and indexing were extracted from Scopus or other scientific databases, for the journals discontinued for publication concerns. Results: A total of 317 journals were evaluated. Ninety-three percent of the journals (294/317) declared they published using an Open Access model. The subject areas with the greatest number of discontinued journals were Medicine (52/317; 16%), Agriculture and Biological Science (34/317; 11%), and Pharmacology, Toxicology and Pharmaceutics (31/317; 10%). The mean number of citations per year after discontinuation was significantly higher than before (median of difference 16.89 citations, p<0.0001), and so was the number of citations per document (median of difference 0.42 citations, p<0.0001). Twenty-two percent (72/317) were included in the Cabell’s blacklist. The DOAJ currently included only 9 journals while 61 were previously included and discontinued, most for 'suspected editorial misconduct by the publisher'. Conclusions: Journals discontinued for 'publication concerns' continue to be cited despite discontinuation and predatory behaviour seemed common. These citations may influence scholars’ metrics prompting artificial career advancements, bonus systems and promotion. Countermeasures should be taken urgently to ensure the reliability of Scopus metrics for the purpose of scientific assessment of scholarly publishing at both journal- and author-level.
Prediction of repurposed drugs for treating lung injury in COVID-19
Authors: He Bing , Garmire Lana 
Published: August 2020

Background: Coronavirus disease (COVID-19) is an infectious disease discovered in 2019 and currently in outbreak across the world. Lung injury with severe respiratory failure is the leading cause of death in COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there still lacks efficient treatment for COVID-19 induced lung injury and acute respiratory failure. Methods: Inhibition of angiotensin-converting enzyme 2 (ACE2) caused by the spike protein of SARS-CoV-2 is the most plausible mechanism of lung injury in COVID-19. We performed drug repositioning analysis to identify drug candidates that reverse gene expression pattern in L1000 lung cell line HCC515 treated with ACE2 inhibitor. We confirmed these drug candidates by similar bioinformatics analysis using lung tissues from patients deceased from COVID-19. We further investigated deregulated genes and pathways related to lung injury, as well as the gene-pathway-drug candidate relationships. Results: We propose two candidate drugs, COL-3 (a chemically modified tetracycline) and CGP-60474 (a cyclin-dependent kinase inhibitor), for treating lung injuries in COVID-19. Further bioinformatics analysis shows that 12 significantly enriched pathways (P-value <0.05) overlap between HCC515 cells treated with ACE2 inhibitor and human COVID-19 patient lung tissues. These include signaling pathways known to be associated with lung injury such as TNF signaling, MAPK signaling and chemokine signaling pathways. All 12 pathways are targeted in COL-3 treated HCC515 cells, in which genes such as RHOA, RAC2, FAS, CDC42 have reduced expression. CGP-60474 shares 11 of 12 pathways with COL-3 and common target genes such as RHOA. It also uniquely targets other genes related to lung injury, such as CALR and MMP14. Conclusions: This study shows that ACE2 inhibition is likely part of the mechanisms leading to lung injury in COVID-19, and that compounds such as COL-3 and CGP-60474 have potential as repurposed drugs for its treatment.
The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis
Authors: Kneebone Ian I. , Fife-Schaw Chris , Lam Lawrence T. , das Nair Roshan 
Published: August 2020

Background: Depression is common in multiple sclerosis (MS); however, its assessment is complicated by biological processes. In this context it is important to consider the performance of depression screening measures including that their factor structure is consistent with expectation. This study sought to identify the factor structure of the Center for Epidemiological Study - Depression Scale (CES-D) in people with MS (PwMS). Methods: Participants (N = 493) were those who had consented to take part in a large three-phase longitudinal study of depression in PwMS. CES-D questionnaires completed at phase 1 of the study were utilised. An error in the questionnaire meant it was most appropriate to consider data for 19 of the 20 CES-D questionnaire items. The data was split into two samples by a random selection process to create an exploratory, model development sample and a validation sample. The first sample was subject to confirmatory factor analysis. Following examination of model fit and specification errors, the original model was modified. The revised model was tested in the confirmation sample to assess reproducibility. Results: The analysis results supported the original four factor solution for the CES-D, that is: Depressed Affect, Positive Affect, Somatic Complaints/Activity Inhibition, and Interpersonal Difficulties. Conclusions: The CES-D appears to have a coherent structure with which to examine depression in PwMS.
Case Report: Pediatric pharmacobezoar with subacute intestinal obstruction
Authors: Hakeem Mahnaz , Lohana Heeramani , Urooj Sarwat , Ahmed Sheraz 
Published: August 2020

Bezoars are an undigested mass causing an intraluminal obstruction in children. Pharmacobezoars are formed from medicines or their vehicle, considered as a less frequent type observed in children. Our objective is to report a relatively rare entity as a potential cause of intestinal obstruction in children. Here we report a case of 13-year-old girl with a history of herbal medicine intake who presented with persistent vomiting and abdominal distension. She was diagnosed with acute intestinal obstruction and managed conservatively without any complications. The patient became stable within two days so was discharged home. We found that ineffective history could lead to a delay in diagnosis and management. Clinicians should have a high index of suspicion for pica and psychiatric disorders, especially in adolescent children.
High SARS-CoV-2 seroprevalence in health care workers but relatively low numbers of deaths in urban Malawi
Authors: Chibwana Marah G. , Jere Khuzwayo C. , Kamng'ona Raphael , Mandolo Jonathan , Katunga-Phiri Vincent , Tembo Dumizulu , Mitole Ndaona , Musasa Samantha , Sichone Simon , Lakudzala Agness , Sibale Lusako , Matambo Prisca , Kadwala Innocent , Byrne Rachel L. , Mbewe Alice , Henrion Marc Y. R. , Morton Ben , Phiri Chimota , Mallewa Jane , Mwandumba Henry C. , Adams Emily R. , Gordon Stephen B. , Jambo Kondwani C. 
Published: August 2020

Background: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing to socioeconomic constraints, leading to predictions that the COVID-19 pandemic would progress rapidly. However, due to limited capacity to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of the true burden of infection and death. We, therefore, conducted a SARS-CoV-2 serosurvey amongst health care workers (HCWs) in Blantyre city to estimate the cumulative incidence of SARS-CoV-2 infection in urban Malawi. Methods: We recruited 500 otherwise asymptomatic HCWs from Blantyre City (Malawi) from 22nd May 2020 to 19th June 2020 and serum samples were collected from all participants. A commercial ELISA was used to measure SARS-CoV-2 IgG antibodies in serum. Results: A total of 84 participants tested positive for SARS-CoV-2 antibodies. The HCWs with positive SARS-CoV-2 antibody results came from different parts of the city. The adjusted seroprevalence of SARS-CoV-2 antibodies was 12.3% [CI 8.2 - 16.5]. Using age-stratified infection fatality estimates reported from elsewhere, we found that at the observed adjusted seroprevalence, the number of predicted deaths was eight times the number of reported deaths. Conclusions: The high seroprevalence of SARS-CoV-2 antibodies among HCWs and the discrepancy in the predicted versus reported deaths suggests that there was early exposure but slow progression of COVID-19 epidemic in urban Malawi. This highlights the urgent need for development of locally parameterised mathematical models to more accurately predict the trajectory of the epidemic in sub-Saharan Africa for better evidence-based policy decisions and public health response planning.
Dispersive microwave electrometry using Zeeman frequency modulation spectroscopy of electromagnetically induced transparency in Rydberg atoms
Authors: Jia Fengdong , Yu Yonghong , Liu Xiubin , Zhang Xi , Zhang Lei , Wang Fei , Mei Jiong , Zhang Jian , Xie Feng , Zhong Zhiping 
Published: August 2020

We herein developed and demonstrated a Zeeman frequency modulation scheme for improving the signal-to-noise ratio of microwave electric field measurement using Rydberg atoms. The spectra of the electromagnetically induced transparency (EIT) and Autler-Townes splitting of Rydberg atoms is frequency modulated by an alternating current magnetic field. The signal-to-noise ratio of the corresponding dispersive error signal is enhanced more than 10 times than that of the original spectrum. Furthermore, we show that the slope of the dispersive error signal near the resonance of the Rydberg EIT can be used to characterize the weak microwave electric field amplitudes. The more intuitive and simpler structure compared with other existing frequency modulation technologies greatly reduces the difficulties of experiments and experimental data analysis.
Does the Media Fail Aboriginal Political Aspirations? 45 Years of News Media Reporting, Amy Thomas, Andrew Jakubowicz and Heidi Norman (2020)
Authors: Waller Lisa 
Published: August 2020

Review of: Does the Media Fail Aboriginal Political Aspirations? 45 Years of News Media Reporting, Amy Thomas, Andrew Jakubowicz and Heidi Norman (2020)
Canberra, ACT: Aboriginal Studies Press, 267 pp.,
ISBN 978-0-85575-084-8, p/bk, $39.95
Akram Khan: Dancing New Interculturalism, Royona Mitra (2015)
Authors: Madhavan Arya 
Published: August 2020

Review of: Akram Khan: Dancing New Interculturalism, Royona Mitra (2015)
London: Palgrave Macmillan, 197 pp.,
ISBN 978-1-34948-363-1, p/bk, £44.58
Overexpression of OsHox-6 Gene Enhanced Tiller Number in Rice But Induced Yield Penalty
Authors: Rahmawati Syamsidah , Chairunnisa Chairunnisa , Erdayani Eva , Nugroho Satya , Estiati Amy 
Published: August 2020

OsHox-6, belongs to the transcription factor homeodomain leucine zipper (HD-Zip) protein sub-family I, has unknown function. This study was aimed to characterize the phenotypes of two homozygous transgenic rice lines (S29-62-2 and S.40.4-158-1) containing an extra copy of OsHox-6 gene under the control of a rice constitutive promoter, OsLEA3, and to evaluate their tolerance to water stress. A real-time quantitative PCR (qRT-PCR) showed that the transcript expression of OsHox-6 gene in the transgenic lines increased 5-10 folds under a normal irrigation and 10-20 folds after exposure to water stress conditions as compared to its wild type control. Transgenic plants overexpressing OsHox-6 exhibited phenotypic alteration at the normal irrigation by inducing tiller formation, suggesting a decrease in the apical dominance. Transgenic plants also showed significant enhancement in the total grain number, however, the number of empty grains also increased significantly (~16-22%). After imposed to the water stress, the number of empty grains in the transgenic lines was even higher (up to 83% in average). Furthermore, observations on the water loss rates, relative water contents and drought resistance indices (DRI) suggested that the overexpression of OsHox-6 did not significantly increase tolerance to water stress. Further research is required to reveal the detailed mechanisms of OsHox-6 in response to water and other abiotic stresses.
Circulação de modelos para o ensino de Ciências Naturais: o método de ensino intuitivo na transição entre Império e República
Authors: Valdemarin Vera Teresa 
Published: August 2020

Este artigo adota a perspectiva histórica (décadas finais do século XIX) para analisar a circulação de prescrições vinculadas ao método de ensino intuitivo. As fontes documentais são dois manuais didáticos dedicados a orientar as práticas pedagógicas de professores primários: Primeiras Lições de Coisas, de N. A. Calkins, publicado em língua portuguesa em 1886 e A Eschola Publica, organizado por Oscar Thompson e outros autores, publicado em 1895. A difusão do método intuitivo ou lições de coisas esteve aliada a transformações pedagógicas que incluem aspectos metodológicos e formação de professores, bem como desenvolvimento social e econômico, tornando-se um símbolo de modernização no estado de São Paulo. Focalizando o ensino de Ciências Naturais, o artigo evidencia diferentes interpretações e sentidos adquiridos pela inovação pedagógica no contexto brasileiro. Essas diferenças explicitam, por sua vez, diferentes concepções sobre a ciência e sobre seu ensino, uma vez que estão assentadas em diferentes formas de raciocínio e hábitos mentais que procuram sedimentar. Um deles, priorizou os passos lógicos para ensinar; o outro foi delimitado às prescrições do currículo escolar.
Attitudes of surgical nurses toward postoperative opioid use: A qualitative study
Authors: Şen Sevim , Usta Esra , Aygin Dilek 
Published: August 2020

Aim: This study was aimed to investigate the attitudes of surgical nurses toward postoperative opioid use. Method: The descriptive phenomenological study consists of 30 surgical nurses in two hospitals in Turkey. Data were collected by semi-structured face to face interviews. Data analyses were done by qualitative theme analysis. Findings: As a result of the theme analysis, six themes related to surgical nurses' attitudes of postoperative opioid analgesic use were identified. These themes are named as follows: primary indications for opioids, safest route for opioid administration, complications observed following opioid administration, opioid addiction, opioid safety, feeling stressed while administrating opioids. Nurses (13/30) stated that intravenous way is safer as it affects fast, and it is easy to control; while 12 nurses said that intramuscular application is safer as there are few possibilities for complications. While all of the nurses were agreed on that opioids are addictive, eighteen of them think that opioid drugs are safe, and 16 stated that administering opioids did not create stress. Conclusions: Nurses face some obstacles related to the use of opioids in the process of pain management, such as the abuse of opioids and encountering side effects. Pain management and opioid use should be given a great place in nursing education.