bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aβ oligomer induced cognitive impairment and evaluation of ACU193‐MNS‐based MRI in rabbit
Authors: Rozema Nicholas B. , Procissi Daniele , Bertolino Nicola , Viola Kirsten L. , Nandwana Vikas , Abdul Nafay , Pribus Sophia , Dravid Vinayak , Klein William L. , Disterhoft John F. , Weiss Craig 
Published: October 2020

AbstractIntroductionAmyloid‐beta oligomers (AβOs) accumulate in Alzheimer's disease and may instigate neuronal pathology and cognitive impairment. We examined the ability of a new probe for molecular magnetic resonance imaging (MRI) to detect AβOs in vivo, and we tested the behavioral impact of AβOs injected in rabbits, a species with an amino acid sequence that is nearly identical to the human sequence.MethodsIntracerebroventricular (ICV) injection with stabilized AβOs was performed. Rabbits were probed for AβO accumulation using ACUMNS (an AβO‐selective antibody [ACU193] coupled to magnetic nanostructures). Immunohistochemistry was used to verify AβO presence. Cognitive impairment was evaluated using object location and object recognition memory tests and trace eyeblink conditioning.ResultsAβOs in the entorhinal cortex of ICV‐injected animals were detected by MRI and confirmed by immunohistochemistry. Injections of AβOs also impaired hippocampal‐dependent, but not hippocampal‐independent, tasks and the area fraction of bound ACUMNs correlated with the behavioral impairment.DiscussionAccumulation of AβOs can be visualized in vivo by MRI of ACUMNS and the cognitive impairment induced by the AβOs can be followed longitudinally with the novel location memory test.
Optimal imaging modality for detection of rectosigmoid deep endometriosis: systematic review and meta‐analysis
Authors: Gerges B. , Li W. , Leonardi M. , Mol B. W. , Condous G. 
Published: October 2020

ABSTRACTObjectivesTo review the accuracy of different imaging modalities for the detection of rectosigmoid deep endometriosis (DE) in women with clinical suspicion of endometriosis, and to determine the optimal modality.MethodsA search was conducted using PubMed, MEDLINE, Scopus, EMBASE and Google Scholar to identify studies using imaging to evaluate women with suspected DE, published from inception to May 2020. Studies were considered eligible if they were prospective and used any imaging modality to assess preoperatively for the presence of DE in the rectum/rectosigmoid, which was then correlated with the surgical diagnosis as the reference standard. Eligibility was restricted to studies including at least 10 affected and 10 unaffected women. The QUADAS‐2 tool was used to assess the quality of the included studies. Mixed‐effects diagnostic meta‐analysis was used to determine the overall pooled sensitivity and specificity of each imaging modality for rectal/rectosigmoid DE, which were used to calculate the likelihood ratio of a positive (LR+) and negative (LR–) test and diagnostic odds ratio (DOR).ResultsOf the 1979 records identified, 30 studies (3374 women) were included in the analysis. The overall pooled sensitivity and specificity, LR+, LR– and DOR for the detection of rectal/rectosigmoid DE using transvaginal sonography (TVS) were, respectively, 89% (95% CI, 83–92%), 97% (95% CI, 95–98%), 30.8 (95% CI, 17.6–54.1), 0.12 (95% CI, 0.08–0.17) and 264 (95% CI, 113–614). For magnetic resonance imaging (MRI), the respective values were 86% (95% CI, 79–91%), 96% (95% CI, 94–97%), 21.0 (95% CI, 13.4–33.1), 0.15 (95% CI, 0.09–0.23) and 144 (95% CI, 70–297). For computed tomography, the respective values were 93% (95% CI, 84–97%), 95% (95% CI, 81–99%), 20.3 (95% CI, 4.3–94.9), 0.07 (95% CI, 0.03–0.19) and 280 (95% CI, 28–2826). For rectal endoscopic sonography (RES), the respective values were 92% (95% CI, 87–95%), 98% (95% CI, 96–99%), 37.1 (95% CI, 21.1–65.4), 0.08 (95% CI, 0.05–0.14) and 455 (95% CI, 196–1054). There was significant heterogeneity and the studies were considered methodologically poor according to the QUADAS‐2 tool.ConclusionsThe sensitivity of TVS for the detection of rectal/rectosigmoid DE seems to be slightly better than that of MRI, although RES was superior to both. The specificity of both TVS and MRI was excellent. As TVS is simpler, faster and more readily available than the other methods, we believe that it should be the first‐line diagnostic tool for women with suspected DE. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
Visitors' perceptions of zoo‐housed lesser anteater (Tamandua tetradactyla) welfare: Observation plays a larger role than a brief informative talk
Authors: Chiapero Florencia , Ferrari Ricardo H. , Guglielmetti Agustín , García Capocasa María C. , Busso Juan M. 
Published: October 2020

AbstractThere is a growing ethical concern in modern society about animals' quality of life. We hypothesize that zoo visitors' perception of zoo animal welfare, particularly in the case of lesser anteaters, changes positively after listening to scientific information. Visitors observing active lesser anteaters in their enclosures at Córdoba Zoo (Argentina) were asked to respond to a questionnaire about animal welfare. The treatment group (T) answered the questionnaire after listening to a brief informative talk based on local scientific studies on lesser anteaters. The control group (C) answered the questionnaire without hearing the informative talk. Visitors (87.2%) considered biological, sanitary, and sociocultural aspects to be necessary conditions for optimum wild zoo‐housed animal welfare. The majority of visitors considered that natural surroundings provide the highest level of welfare for wild animals. Visitors in the T group ranked the zoo as providing a higher level of animal welfare than those in group C. In reference to management measurements, the T group agreed on the positive effect of the application of environmental enrichment (Likert Medians: C = 4 and T = 5; p = .0443). On the basis of their perception, most visitors in both groups stated that the lesser anteaters at Córdoba Zoo appeared to be in a good state of welfare. We interpret this as meaning that, what these Córdoba zoo visitors personally perceived while observing the lesser anteaters carried greater weight than what they learned from the informative talk, though the talk did slightly affect their opinion.
More on heavy-light bootstrap up to double-stress-tensor
Authors: Li Yue-Zhou , Zhang Hao-Yu 
Published: October 2020

Abstract
We investigate the heavy-light four-point function up to double-stress-tensor, supplementing 1910.06357. By using the OPE coefficients of lowest-twist double-stress- tensor in the literature, we find the Regge behavior for lowest-twist double-stress-tensor in general even dimension within the large impact parameter regime. In the next, we perform the Lorentzian inversion formula to obtain both the OPE coefficients and anomalous dimensions of double-twist operators [$$ \mathcal{O} $$
O
H$$ \mathcal{O} $$
O
L]n,J with finite spin J in d = 4. We also extract the anomalous dimensions of double-twist operators with finite spin in general dimension, which allows us to address the cases that ∆L is specified to the poles in lowest-twist double-stress-tensors where certain double-trace operators [$$ \mathcal{O} $$
O
L$$ \mathcal{O} $$
O
L]n,J mix with lowest-twist double-stress-tensors. In particular, we verify and discuss the Residue relation that deter- mines the product of the mixed anomalous dimension and the mixed OPE. We also present the double-trace and mixed OPE coefficients associated with ∆L poles in d = 6, 8. In the end, we turn to discuss CFT2, we verify the uniqueness of double-stress-tensor that is consistent with Virasoso symmetry.
Towards an explicit construction of de Sitter solutions in classical supergravity
Authors: Kim Nakwoo 
Published: October 2020

Abstract
We revisit the stringy construction of four-dimensional de-Sitter solutions using orientifolds O8±, proposed by Córdova et al. (2019) [1]. While the original analysis of the supergravity equations is largely numerical, we obtain semi-analytic solutions by treating the curvature as a perturbative parameter. At each order we verify that the (permissive) boundary conditions at the orientifolds are satisfied. To illustrate the advantage of our result, we calculate the four-dimensional Newton constant as a function of the cosmological constant. We also discuss how the discontinuities at O8− can be accounted for in terms of corrections to the worldvolume action.
Monodromy charge in D7-brane inflation
Authors: Kim Manki , McAllister Liam 
Published: October 2020

AbstractIn axion monodromy inflation, traversingNaxion periods corresponds to dischargingNunits of a quantized charge. In certain models with moving D7-branes, such as Higgs-otic inflation, this monodromy charge is D3-brane charge induced on the D7-branes. The stress-energy of the induced charge affects the internal space, changing the inflaton potential and potentially limiting the field range. We compute the backreaction of induced D3-brane charge in Higgs-otic inflation. The effect on the nonperturbative superpotential is dramatic even forN= 1, and may preclude large-field inflation in this model in the absence of a mechanism to control the backreaction.
The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review
Authors: Williams Maya , Todd Ian , Fairclough Lucy C. 
Published: October 2020

AbstractObjective and designThis systematic review aims to establish the role of CD8 + T lymphocytes in COPD.MethodsForty-eight papers published in the last 15 years were identified for inclusion.ResultsCD8 + T-cells are increased in the lungs of patients with COPD (17 studies, 16 positive) whereas in the circulation, findings were inconclusive. Activation of CD8 + T-cells was enhanced in lungs (four studies, three positive) but cell phenotype was unclear. There was substantial evidence of a higher proportion of type 1 CD8 + (Tc1) cells in COPD (11 studies, 9 positive), though the population of type 2 (Tc2) cells was also increased (5 studies, 4 positive). CD8 + T-cells in COPD exhibited greater expression of cytotoxic proteins (five studies, five positive). Studies assessed a variety of questions so evidence was insufficient to draw firm conclusions. The role of CD8 + T-cells at acute exacerbation of COPD and also their contribution to alveolar destruction can only be hypothesised at this stage.ConclusionsNot only is the number of CD8 + T-cells increased in COPD, these cells have increased capacity to exert effector functions and are likely to contribute to disease pathogenesis. Several mechanisms highlighted show promise for future investigation to consolidate current knowledge.
Stability of the Enhanced Area Law of the Entanglement Entropy
Authors: Müller Peter , Schulte Ruth 
Published: October 2020

AbstractWe consider a multi-dimensional continuum Schrödinger operator which is given by a perturbation of the negative Laplacian by a compactly supported potential. We establish both an upper bound and a lower bound on the bipartite entanglement entropy of the ground state of the corresponding quasi-free Fermi gas. The bounds prove that the scaling behaviour of the entanglement entropy remains a logarithmically enhanced area law as in the unperturbed case of the free Fermi gas. The central idea for the upper bound is to use a limiting absorption principle for such kinds of Schrödinger operators.
On the well posedness of static boundary value problem within the linear dilatational strain gradient elasticity
Authors: Eremeyev Victor A. , Lurie Sergey A. , Solyaev Yury O. , dell’Isola Francesco 
Published: October 2020

AbstractIn this paper, it is proven an existence and uniqueness theorem for weak solutions of the equilibrium problem for linear isotropic dilatational strain gradient elasticity. Considered elastic bodies have as deformation energy the classical one due to Lamé but augmented with an additive term that depends on the norm of the gradient of dilatation: only one extra second gradient elastic coefficient is introduced. The studied class of solids is therefore related to Korteweg or Cahn–Hilliard fluids. The postulated energy naturally induces the space in which the aforementioned well-posedness result can be formulated. In this energy space, the introduced norm does involve the linear combination of some specific higher-order derivatives only: it is, in fact, a particular example of anisotropic Sobolev space. It is also proven that aforementioned weak solutions belongs to the space $$H^1(div,V)$$

H
1

(
d
i
v
,
V
)

, i.e. the space of $$H^1$$

H
1

functions whose divergence belongs to $$H^1$$

H
1

. The proposed mathematical frame is essential to conceptually base, on solid grounds, the numerical integration schemes required to investigate the properties of dilatational strain gradient elastic bodies. Their energy, as studied in the present paper, has manifold interests. Mathematically speaking, its singularity causes interesting mathematical difficulties whose overcoming leads to an increased understanding of the theory of second gradient continua. On the other hand, from the mechanical point of view, it gives an example of energy for a second gradient continuum which can sustain externally applied surface forces and double forces but cannot sustain externally applied surface couples. In this way, it is proven that couple stress continua, introduced by Toupin, represent only a particular case of the more general class of second gradient continua. Moreover, it is easily checked that for dilatational strain gradient continua, balance of force and balance of torques (or couples) are not enough to characterise equilibrium: to this aim, externally applied surface double forces must also be specified. As a consequence, the postulation scheme based on variational principles seems more suitable to study second gradient continua. It has to be remarked finally that dilatational strain gradient seems suitable to model the experimentally observed behaviour of some material used in 3D printing process.
Anomaly detection and event mining in cold forming manufacturing processes
Authors: Nieves Avendano Diego , Caljouw Daniel , Deschrijver Dirk , Van Hoecke Sofie 
Published: October 2020

AbstractPredictive maintenance is one of the main goals within the Industry 4.0 trend. Advances in data-driven techniques offer new opportunities in terms of cost reduction, improved quality control, and increased work safety. This work brings data-driven techniques for two predictive maintenance tasks: anomaly detection and event prediction, applied in the real-world use case of a cold forming manufacturing line for consumer lifestyle products by using acoustic emissions sensors in proximity of the dies of the press module. The proposed models are robust and able to cope with problems such as noise, missing values, and irregular sampling. The detected anomalies are investigated by experts and confirmed to correspond to deviations in the normal operation of the machine. Moreover, we are able to find patterns which are related to the events of interest.
Regional gravity field refinement for (quasi-) geoid determination based on spherical radial basis functions in Colorado
Authors: Liu Qing , Schmidt Michael , Sánchez Laura , Willberg Martin 
Published: October 2020

AbstractThis study presents a solution of the ‘1 cm Geoid Experiment’ (Colorado Experiment) using spherical radial basis functions (SRBFs). As the only group using SRBFs among the fourteen participated institutions from all over the world, we highlight the methodology of SRBFs in this paper. Detailed explanations are given regarding the settings of the four most important factors that influence the performance of SRBFs in gravity field modeling, namely (1) the choosing bandwidth, (2) the locations of the SRBFs, (3) the type of the SRBFs as well as (4) the extensions of the data zone for reducing the edge effect. Two types of basis functions covering the same spectral range are used for the terrestrial and the airborne measurements, respectively. The non-smoothing Shannon function is applied to the terrestrial data to avoid the loss of spectral information. The cubic polynomial (CuP) function which has smoothing features is applied to the airborne data as a low-pass filter for filtering the high-frequency noise. Although the idea of combining different SRBFs for different observations was proven in theory to be possible, it is applied to real data for the first time, in this study. The RMS error of our height anomaly result along the GSVS17 benchmarks w.r.t the validation data (which is the mean results of the other contributions in the ‘Colorado Experiment’) drops by 5% when combining the Shannon function for the terrestrial data and the CuP function for the airborne data, compared to those obtained by using the Shannon function for both the two data sets. This improvement indicates the validity and benefits of using different SRBFs for different observation types. Global gravity model (GGM), topographic model, the terrestrial gravity data, as well as the airborne gravity data are combined, and the contribution of each data set to the final solution is discussed. By adding the terrestrial data to the GGM and the topographic model, the RMS error of the height anomaly result w.r.t the validation data drops from 4 to 1.8 cm, and it is further reduced to 1 cm by including the airborne data. Comparisons with the mean results of all the contributions show that our height anomaly and geoid height solutions at the GSVS17 benchmarks have an RMS error of 1.0 cm and 1.3 cm, respectively; and our height anomaly results give an RMS value of 1.6 cm in the whole study area, which are all the smallest among the participants.
Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics
Authors: Kasteel Emma E. J. , Nijmeijer Sandra M. , Darney Keyvin , Lautz Leonie S. , Dorne Jean Lou C. M. , Kramer Nynke I. , Westerink Remco H. S. 
Published: October 2020

AbstractIn chemical risk assessment, default uncertainty factors are used to account for interspecies and interindividual differences, and differences in toxicokinetics and toxicodynamics herein. However, these default factors come with little scientific support. Therefore, our aim was to develop an in vitro method, using acetylcholinesterase (AChE) inhibition as a proof of principle, to assess both interspecies and interindividual differences in toxicodynamics. Electric eel enzyme and human blood of 20 different donors (12 men/8 women) were exposed to eight different compounds (chlorpyrifos, chlorpyrifos-oxon, phosmet, phosmet-oxon, diazinon, diazinon-oxon, pirimicarb, rivastigmine) and inhibition of AChE was measured using the Ellman method. The organophosphate parent compounds, chlorpyrifos, phosmet and diazinon, did not show inhibition of AChE. All other compounds showed concentration-dependent inhibition of AChE, with IC50s in human blood ranging from 0.2–29 µM and IC20s ranging from 0.1–18 µM, indicating that AChE is inhibited at concentrations relevant to the in vivo human situation. The oxon analogues were more potent inhibitors of electric eel AChE compared to human AChE. The opposite was true for carbamates, pointing towards interspecies differences for AChE inhibition. Human interindividual variability was low and ranged from 5–25%, depending on the concentration. This study provides a reliable in vitro method for assessing human variability in AChE toxicodynamics. The data suggest that the default uncertainty factor of ~ 3.16 may overestimate human variability for this toxicity endpoint, implying that specific toxicodynamic-related adjustment factors can support quantitative in vitro to in vivo extrapolations that link kinetic and dynamic data to improve chemical risk assessment.
Countercurrent chromatographic fractionation followed by gas chromatography/mass spectrometry identification of alkylresorcinols in rye
Authors: Hammerschick Tim , Wagner Tim , Vetter Walter 
Published: October 2020

AbstractAlkylresorcinols (5-alkyl-1,3-dihydroxybenzenes, ARs) are bioactive phenolic lipid compounds which are particularly abundant in rye and partly other cereals. In this study on ARs, whole rye grain extracts were gained with cyclohexane/ethyl acetate (46/54, w/w). Silylated extracts were used to develop a gas chromatography with mass spectrometry method in the selected ion monitoring mode (GC/MS-SIM) for the sensitive detection of conventional ARs along with keto-substituted (oxo-AR) and ring-methylated ARs (mAR) with 5-alkyl chain lengths of 14 to 27 carbon atoms and 0 to 4 double bonds in one run. Analysis was performed by countercurrent chromatographic (CCC) fractionation using the solvent system n-hexane/ethyl acetate/methanol/water (9/1/9/1, v/v/v/v). Subsequent GC/MS-(SIM) analysis of 80 silylated CCC fractions enabled the detection of 74 ARs in the sample. The CCC elution of the ARs followed the equivalent chain length (ECL) rule in which one double bond compensated the effect of two (additional) carbon atoms. Novel or rarely reported ARs were detected in virtually all classes, i.e. saturated AR (AR14:0), even-numbered monounsaturated AR isomers (AR16:1-AR26:1), triunsaturated ARs (AR25:3), oxo-ARs (AR17:0 oxo, AR19:1 oxo, AR21:2 oxo, AR23:2 oxo) and odd-numbered methyl-ARs (mAR15:0-mAR23:0). Positions of the double bonds of monounsaturated ARs and oxo-ARs were determined with the help of dimethyl disulfide (DMDS) derivatives.
Factors Affecting Women Surgeons’ Careers in Low–Middle‐Income Countries: An International Survey
Authors: Malik Mahim , Inam Hina , Janjua Mahin B. N. , Martins Russell S. , Zahid Nida , Khan Sadaf , Sattar Abida K. , Haider Adil H. , Enam Syed Ather 
Published: October 2020

AbstractBackgroundDespite increasing numbers of women surgeons globally, barriers to career advancement persist. While these barriers have been extensively discussed in high‐income countries (HICs), the topic has received minimal attention in lower–middle‐income countries (LMICs) like Pakistan.MethodsThe Association of Women Surgeons of Pakistan (AWSP)—an organization in Pakistan consisting of female surgeons and trainees—carried out this international cross‐sectional study over July–Sept 2019. An anonymous online survey was disseminated via social media platforms and various institutions across Pakistan and internationally.ResultsA total of 218 female surgeons responded to the survey, with 146 (67%) from Pakistan and 72 (33%) from HICs. While HIC surgeons were more likely to report gender discrimination/bias (GD/bias) during residency (29.2% vs 11.6%; p = 0.001), more Pakistani surgeons reported that GD/bias negatively affected their job satisfaction (80.7% vs. 64.9%; p = 0.024). GD/bias manifested most commonly as differences in mentoring relationships (72%). A higher percentage Pakistani surgeons reported having experienced a family‐related interruption in their career (24.7% vs. 11.1%; p = 0.019). The vast majority (95%) felt that surgery was perceived as a masculine field, and the majority (56.4%) of respondents reported having been told that they could not be a surgeon because of their gender.ConclusionOur study highlights keys factors that must be addressed to provide equal career opportunities to women surgeons. It is the responsibility of surgical educators, policy makers, and healthcare organizations to facilitate women surgeons’ career progression by developing systems that support equitable career growth for women surgeons.