bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indexed left ventricular mass to QRS voltage ratio is associated with heart failure hospitalizations in patients with cardiac amyloidosis
Authors: Slivnick Jeremy A. , Wallner Alexander L. , Vallakati Ajay , Truong Vien T. , Mazur Wojciech , Elamin Mohamed B. , Tong Matthew S. , Raman Subha V. , Zareba Karolina M. 
Published: October 2020

AbstractIn cardiac amyloidosis (CA), amyloid infiltration results in increased left ventricular (LV) mass disproportionate to electrocardiographic (EKG) voltage. We assessed the relationship between LV mass–voltage ratio with subsequent heart failure hospitalization (HHF) and mortality in CA. Patients with confirmed CA and comprehensive cardiovascular magnetic resonance (CMR) and EKG exams were included. CMR-derived LV mass was indexed to body surface area. EKG voltage was assessed using Sokolow, Cornell, and Limb–voltage criteria. The optimal LV mass–voltage ratio for predicting outcomes was determined using receiver operating characteristic curve analysis. The relationship between LV mass–voltage ratio and HHF was assessed using Cox proportional hazards analysis adjusting for significant covariates. A total of 85 patients (mean 69 ± 11 years, 22% female) were included, 42 with transthyretin and 43 with light chain CA. At a median of 3.4-year follow-up, 49% of patients experienced HHF and 60% had died. In unadjusted analysis, Cornell LV mass–voltage ratio was significantly associated with HHF (HR, 1.05; 95% CI 1.02–1.09, p = 0.001) and mortality (HR, 1.05; 95% CI 1.02–1.07, p = 0.001). Using ROC curve analysis, the optimal cutoff value for Cornell LV mass–voltage ratio to predict HHF was 6.7 gm/m2/mV. After adjusting for age, NYHA class, BNP, ECV, and LVEF, a Cornell LV mass–voltage ratio > 6.7 gm/m2/mV was significantly associated with HHF (HR 2.25, 95% CI 1.09–4.61; p = 0.03) but not mortality. Indexed LV mass–voltage ratio is associated with subsequent HHF and may be a useful prognostic marker in cardiac amyloidosis.
Leber hereditary optic neuropathy following head trauma and ocular trauma on contralateral eye: a case report
Authors: Kim Hoon Dong 
Published: October 2020

Abstract
Purpose
To present a case of activation of Leber hereditary optic neuropathy (LHON) following head and ocular trauma of the fellow eye in the patient with no remarkable symptoms and normal visual acuity prior to trauma.

Case summary
A 31-year-old healthy man was referred to our hospital after a traffic accident. He had blowout fractures of medial and inferior orbital wall of the left eye, subcutaneous hematoma of the left forehead, and bony fragment that compressed the left optic nerve. Initially, best-corrected visual acuity (BCVA) was 20/20 in the right and 20/1000 in the left eyes. Relative afferent pupillary defect of the left eye was apparent, and fundus examination revealed choroidal rupture circumferentially crossing the macular area. Nine months later, the patient complained with gradual vision loss in the right eye, which was the contralateral eye of the ocular trauma. BCVA was 20/200, and perimetry revealed cecocentral scotoma in the right eye. BCVA in both eyes reduced to 20/2000 1 year post-trauma. Visual evoked potentials revealed markedly decreased in amplitudes and elongated latencies for both eyes. Mitochondrial DNA analysis revealed a G11778A mutation; therefore, a diagnosis of activation of LHON followed by trauma was made for the previously unaffected carrier.

Conclusions
This is a case in which activation of LHON occurred in a healthy carrier following head and ocular trauma of the fellow eye. This observation suggests the possibility that LHON activation in healthy carriers may occur in patients who experience head or ocular trauma even in the fellow eye.
Dynamical Phenomena and Their Models: Truth and Empirical Correctness
Authors: Giunti Marco 
Published: October 2020

AbstractIn the epistemological tradition, there are two main interpretations of the semantic relation that an empirical theory may bear to the real world. According to realism, the theory-world relationship should be conceived as truth; according to instrumentalism, instead, it should be limited to empirical adequacy. Then, depending on how empirical theories are conceived, either syntactically as a class of sentences, or semantically as a class of models, the concepts of truth and empirical adequacy assume different and specific forms. In this paper, we review two main conceptions of truth (one sentence-based and one model-based) and two of empirical adequacy (one sentence-based and one model-based), we point out their respective difficulties, and we give a first formulation of a new general view of the theory-world relationship, which we call Methodological Constructive Realism (MCR). We then show how the content of MCR can be further specified and expressed in a definite and precise form. The bulk of the paper shows in detail how it is possible to accomplish this goal for the special case of deterministic dynamical phenomena and their correlated deterministic models. This special version of MCR is formulated as an axiomatic extension of set theory, whose specific axioms constitute a formal ontology that provides an adequate framework for analyzing the two semantic relations of truth and empirical correctness, as well as their connections.
The Impact of Navya-Nyāya on Mādhva Vedānta: Vyāsatīrtha and the Problem of Empty Terms
Authors: Williams Michael Thomas 
Published: October 2020

AbstractIn this article, I explore the encounter of the Mādhva philosopher Vyāsatīrtha with the works of the Navya-Naiyāyika Gaṅgeśa Upādhyāya. The article is based on original translations of passages from Vyāsatīrtha’s Nyāyāmr̥ta and Tarkatāṇḍava. Philosophically, the article focuses on the issue of empty-terms/nonexistent entities, particularly in the context of the theory of inference. I begin by outlining the origin of the Mādhva and Nyāya positions about these issues in their respective analyses of perceptual illusion. I then contrast the role of Gaṅgeśa’s thought in the Nyāyāmr̥ta and Tarkatāṇḍava and show how Vyāsatīrtha responds to Gaṅgeśa’s ideas in different ways in those texts. I conclude with a discussion of how Vyāsatīrtha defends the Mādhva theory of “substrate-free” qualities against Gaṅgeśa in order to show that we can think and make valid inferences about nonexistent things.
The DIRECT algorithm: 25 years Later
Authors: Jones Donald R. , Martins Joaquim R. R. A. 
Published: October 2020

AbstractIntroduced in 1993, the DIRECT global optimization algorithm provided a fresh approach to minimizing a black-box function subject to lower and upper bounds on the variables. In contrast to the plethora of nature-inspired heuristics, DIRECT was deterministic and had only one hyperparameter (the desired accuracy). Moreover, the algorithm was simple, easy to implement, and usually performed well on low-dimensional problems (up to six variables). Most importantly, DIRECT balanced local and global search (exploitation vs. exploration) in a unique way: in each iteration, several points were sampled, some for global and some for local search. This approach eliminated the need for “tuning parameters” that set the balance between local and global search. However, the very same features that made DIRECT simple and conceptually attractive also created weaknesses. For example, it was commonly observed that, while DIRECT is often fast to find the basin of the global optimum, it can be slow to fine-tune the solution to high accuracy. In this paper, we identify several such weaknesses and survey the work of various researchers to extend DIRECT so that it performs better. All of the extensions show substantial improvement over DIRECT on various test functions. An outstanding challenge is to improve performance robustly across problems of different degrees of difficulty, ranging from simple (unimodal, few variables) to very hard (multimodal, sharply peaked, many variables). Opportunities for further improvement may lie in combining the best features of the different extensions.
Absolute and relative measurement of the 243Am half-life
Authors: Marouli M. , Pommé S. , Jobbágy V. , Stroh H. , Van Ammel R. , Fankhauser A. , Jakopič R. , Richter S. , Aregbe Y. , Crozet M. , Maillard C. , Rivier C. , Roudil D. 
Published: October 2020

AbstractThe half-life of 243Am has been measured by an absolute and a relative method, i.e. by determining the specific activity of 243Am and the specific activity ratio with 241Am. A mixed 241,243Am reference material was produced and certified for its americium mass content and its isotope amount ratios. The characterisation of the mass content of 243Am was established by isotope dilution mass spectrometry using an 241Am spike, produced from highly enriched 241Pu material. The isotope amount ratios n(241Am)/n(243Am) and n(242mAm)/n(243Am) were measured by thermal ionisation mass spectrometry. Activity measurements were performed by alpha-particle counting at a defined solid angle, as well as high-resolution alpha-particle spectrometry. From the 243Am/241Am activity and isotopic amount ratios, a value of 16.988 (24) was derived for the 243Am/241Am half-life ratio. Using a value of 432.6 (6) a for the 241Am half-life, the corresponding 243Am half-life value, 7349 (15) a, is in good agreement with the result obtained from the absolute method, 7342 (14) a. The mean value, 7345 (14) a, agrees well with data from literature and lowers the relative standard uncertainty to 0.2%.
Electoral integrity matters: how electoral process conditions the relationship between political losing and political trust
Authors: Mauk Marlene 
Published: October 2020

AbstractThis contribution adds a new perspective to the debate on electoral integrity by asking how electoral integrity affects the way in which election results translate into citizen attitudes towards the political system. It introduces a causal mechanism that links political losing to political trust via evaluations of electoral fairness: citizens who voted for the losing camp are more likely to view the electoral process as unfair than citizens who voted for the winning camp, resulting in political distrust. It further suggests that the effects of political losing on political trust depend on the level of electoral integrity. In conditions where the elections were conducted in a free and fair manner, even those who voted for the losing camp have little reason to suspect foul play and therefore political losing should barely affect perceptions of the electoral process. Whenever there are actual indications of electoral malpractice, however, political losers have much more reason to doubt the integrity of the electoral process than those who are content with the outcome of the election. The contribution makes use of a unique dataset that ex-post harmonizes survey data from three cross-national survey projects (Asian Barometer Survey, European Social Survey, Latinobarómetro) and macro-level data from the Varieties-of-Democracy Project to cover 45 democracies in Europe, East Asia, and Latin America. Using multi-level modeling, it finds that political losing indeed decreases political trust indirectly via perceptions of electoral fairness. Confirming its key proposition, the empirical analysis shows that political losing has a weaker effect on political trust in countries where electoral integrity is high.
Are cooperative firms more agile? A contingency perspective on small and medium-sized enterprises in agglomerations and peripheral areas
Authors: Mueller Elisabeth F. , Jungwirth Carola 
Published: October 2020

AbstractIn this study of small and medium-sized enterprises (SMEs) operating in German key technology industries, we investigate whether cooperating with others is an effective strategy for SMEs to enhance their organizational agility. Taking a contingency perspective, we are specifically interested in whether this effect depends on the firm’s location in an agglomerated or a peripheral area. Results show that a greater number of cooperative relationships with others is positively associated with SMEs’ organizational agility. This effect is stronger for agglomerated than for peripheral firms, suggesting that agglomerated SMEs can seize the abundant opportunities to cooperate in order to counter agglomeration diseconomies such as organizational inertia and mimetic behavior. This finding highlights the importance of absorbing external knowledge gained in cooperative relationships for SMEs’ organizational agility. Thereby, the study offers a novel perspective on how agglomerated SMEs can actively prevent being negatively affected by the downsides of agglomerations.
What is neurophilosophy: Do we need a non-reductive form?
Authors: Klar Philipp 
Published: October 2020

AbstractNeurophilosophy is a controversial scientific discipline lacking a broadly accepted definition and especially a well-elaborated methodology. Views about what neurophilosophy entails and how it can combine neuroscience with philosophy, as in their branches (e.g. metaphysics, epistemology, ethics) and methodologies, diverge widely. This article, first of all, presents a brief insight into the naturalization of philosophy regarding neurophilosophy and three resulting distinguishable forms of how neuroscience and philosophy may or may not be connected in part 1, namely reductive neurophilosophy, the parallelism between neuroscience and philosophy which keeps both disciplines rather strictly separated and lastly, non-reductive neurophilosophy which aims for a bidirectional connection of both disciplines. Part 2 presents a paradigmatic example of how these three forms of neuroscience and philosophy approach the problem of self, mainly concerning its ontological status (existence and reality). This allows me to compare all three neurophilosophical approaches with each other and to highlight the benefits of a non-reductive form of neurophilosophy. I conclude that especially non-reductive neurophilosophy can give full justice to the complementary position of neurophilosophy right at the intersection between neuroscience, philosophy, and psychology.
Bioactivity of volatile organic compounds by Aureobasidium species against gray mold of tomato and table grape
Authors: Di Francesco A. , Zajc J. , Gunde-Cimerman N. , Aprea E. , Gasperi F. , Placì N. , Caruso F. , Baraldi E. 
Published: October 2020

AbstractAureobasidium strains isolated from diverse unconventional environments belonging to the species A. pullulans, A. melanogenum, and A. subglaciale were evaluated for Volatile Organic Compounds (VOCs) production as a part of their modes of action against Botrytis cinerea of tomato and table grape. By in vitro assay, VOCs generated by the antagonists belonging to the species A. subglaciale showed the highest inhibition percentage of the pathogen mycelial growth (65.4%). In vivo tests were conducted with tomatoes and grapes artificially inoculated with B. cinerea conidial suspension, and exposed to VOCs emitted by the most efficient antagonists of each species (AP1, AM10, AS14) showing that VOCs of AP1 (A. pullulans) reduced the incidence by 67%, partially confirmed by the in vitro results. Conversely, on table grape, VOCs produced by all the strains did not control the fungal incidence but were only reducing the infection severity (< 44.4% by A. pullulans; < 30.5% by A. melanogenum, and A. subglaciale). Solid-phase microextraction (SPME) and subsequent gas chromatography coupled to mass spectrometry identified ethanol, 3-methyl-1-butanol, 2-methyl-1-propanol as the most produced VOCs. However, there were differences in the amounts of produced VOCs as well as in their repertoire. The EC50 values of VOCs for reduction of mycelial growth of B. cinerea uncovered 3-methyl-1-butanol as the most effective compound. The study demonstrated that the production and the efficacy of VOCs by Aureobasidium could be directly related to the specific species and pathosystem and uncovers new possibilities for searching more efficient VOCs producing strains in unconventional habitats other than plants.
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
Authors: Rauen Katrin , Späni Claudia B. , Tartaglia Maria Carmela , Ferretti Maria Teresa , Reichelt Lara , Probst Philipp , Schäpers Barbara , Müller Friedemann , Jahn Klaus , Plesnila Nikolaus 
Published: October 2020

AbstractTraumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet not clarified. In this cross-sectional study, we present age- and sex-related demographics and HRQoL up to 10 years after TBI using the Quality of Life after Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero to 100 indicating good (≥ 60), moderate (40–59) or unfavorable (< 40) HRQoL. Two-thirds of the entire chronic TBI cohort (102 males; 33 females) aged 18–85 years reported good HRQoL up to 10 years after TBI. TBI etiology differed between sexes with females suffering more often from traffic- than fall-related TBI (p = 0.01) with increasing prevalence during aging (p = < 0.001). HRQoL (good/moderate/unfavorable) differed between sexes (p < 0.0001) with 17% more females reporting moderate outcome (p = 0.01). Specifically, older females (54–76-years at TBI) were affected, while males constantly reported good HRQoL (p = 0.017). Cognition (p = 0.014), self-perception (p = 0.009), and emotions (p = 0.016) rather than physical problems (p = 0.1) constrained older females’ HRQoL after TBI. Experiencing TBI during aging does not influence HRQoL outcome in males but females suggesting that female brains cope less well with a traumatic injury during aging. Therefore, older females need long-term follow-ups after TBI to detect neuropsychiatric sequels that restrict their quality of life. Further investigations are necessary to uncover the mechanisms of this so far unknown phenomenon.
Solid fraction of separated digestate as soil improver: implications for soil fertility and carbon sequestration
Authors: Egene Caleb Elijah , Sigurnjak Ivona , Regelink Inge C. , Schoumans Oscar F. , Adani Fabrizio , Michels Evi , Sleutel Steven , Tack Filip M. G. , Meers Erik 
Published: October 2020

AbstractPurposeThis study investigated the C and N mineralisation potential of solid fractions (SFs) from co-digestated pig manure after P-stripping (P-POOR SF) in comparison with P-rich SFs, as a means to estimate their organic matter stability in soil. Compost (COMP) and biochar (BCHR) (made from P-POOR SF) were also included in the study as reference biosolids.MethodsThe SFs were incubated in a sandy-loam soil under moist conditions to determine production of CO2and mineral N. At specified intervals, CO2evolution in the mixtures was measured via the alkali trap method and titration over a period of 81 days, while mineral N was measured using a flow analyser after KCl extraction over a period of 112 days.ResultsThe various SFs showed similar patterns of C mineralisation (15–26% of added total C in 81 days) that were clearly higher than for COMP and BCHR (6% and 7%, respectively). Temporary N immobilisation was observed in biosolids with a high C/N ratio. The effective organic matter (EOM) of the SFs was calculated based on the C mineralisation data and varied between 130 and 369 kg Mg−1.ConclusionsThe SF with a reduced P content had a high EOM/P ratio which is beneficial in areas where P status of the soil is already high. Moreover, the N mineralisation patterns confirm that a high C/N ratio may also reduce risks for N leaching due to temporary N immobilisation.
Probing surface interactions of underwater oleophobic polyelectrolyte multilayers
Authors: Li Kai , Wang Wei , Yu Zhi-Peng , Jin Hang , Ge Yun-Tong , Gao Wei-Wei , Xiao Fan , Huang Hui-Rong , Peng Ze-Heng , Gong Jing 
Published: October 2020

AbstractIn the present work, the interaction mechanism of specific polyelectrolyte multilayers (PEMs), fabricated by layer-by-layer deposition of polydiallyldimethylammonium chloride (PDDA) and poly(sodium 4-styrenesulfonate) (PSS), is studied using atomic force microscopy. The underwater oil-repellency of PSS-capped PEMs was further explored by measuring the interaction forces between tetradecane droplets and PEMs-coated silica substrates under various salinities. The force curves were analyzed following the Stokes–Reynolds–Young–Laplace theoretical model. Desirable consistency was achieved between the experimental and theoretical calculations at low NaCl concentrations (0.1 mM and 1 mM); however, underestimation of the attractive force was found as the NaCl concentration increases to moderate (10 mM) and high (100 mM) levels. Discrepancy analyses and incorporated features toward a reduced surface charge density were considered based on the previous findings of the orientation of anionic benzenesulfonate moieties (Liu et al. in Angew Chem Int Ed 54(16):4851–4856, 2015. https://doi.org/10.1002/anie.201411992). Short-range steric hindrance interactions were further introduced to simulate “brush” effect stemming from nanoscale surface roughness. It is demonstrated in our work that the PSS-capped PEMs remains a stable underwater lipophobicity against high salinity, which renders it potential application in surface wetting modification and anti-fouling.
On reconstructing subvarieties from their periods
Authors: Movasati Hossein , Sertöz Emre Can 
Published: October 2020

AbstractWe give a new practical method for computing subvarieties of projective hypersurfaces. By computing the periods of a given hypersurfaceX, we find algebraic cohomology cycles onX. On well picked algebraic cycles, we can then recover the equations of subvarieties ofXthat realize these cycles. In practice, a bulk of the computations involve transcendental numbers and have to be carried out with floating point numbers. However, ifXis defined over algebraic numbers then the coefficients of the equations of subvarieties can be reconstructed as algebraic numbers. A symbolic computation then verifies the results. As an illustration of the method, we compute generators of the Picard groups of some quartic surfaces. A highlight of the method is that the Picard group computations are proved to be correct despite the fact that the Picard numbers of our examples are not extremal.