bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burkholder–Davis–Gundy Inequalities in UMD Banach Spaces
Authors: Yaroslavtsev Ivan 
Published: September 2020

AbstractIn this paper we prove Burkholder–Davis–Gundy inequalities for a general martingaleMwith values in a UMD Banach spaceX. Assuming that$$M_0=0$$M0=0, we show that the following two-sided inequality holds for all$$1\le p<\infty $$1≤p<∞: Here$$ \gamma ([\![M]\!]_t) $$γ([[M]]t)is the$$L^2$$L2-norm of the unique Gaussian measure onXhaving$$[\![M]\!]_t(x^*,y^*):= [\langle M,x^*\rangle , \langle M,y^*\rangle ]_t$$[[M]]t(x∗,y∗):=[⟨M,x∗⟩,⟨M,y∗⟩]tas its covariance bilinear form. This extends to general UMD spaces a recent result by Veraar and the author, where a pointwise version of ($$\star $$⋆) was proved for UMD Banach functions spacesX. We show that for continuous martingales, ($$\star $$⋆) holds for all$$0<p<\infty $$0<p<∞, and that for purely discontinuous martingales the right-hand side of ($$\star $$⋆) can be expressed more explicitly in terms of the jumps ofM. For martingales with independent increments, ($$\star $$⋆) is shown to hold more generally in reflexive Banach spacesXwith finite cotype. In the converse direction, we show that the validity of ($$\star $$⋆) for arbitrary martingales implies the UMD property forX. As an application we prove various Itô isomorphisms for vector-valued stochastic integrals with respect to general martingales, which extends earlier results by van Neerven, Veraar, and Weis for vector-valued stochastic integrals with respect to a Brownian motion. We also provide Itô isomorphisms for vector-valued stochastic integrals with respect to compensated Poisson and general random measures.
Der Einsatz von Immuncheckpoint-Inhibitoren im onkologischen Alltag
Authors: Schardt Julian 
Published: September 2020

Zusammenfassung
Hintergrund
Die Einführung von Immuncheckpoint-Inhibitoren (ICI) hat die Behandlungskonzepte der Onkologie für eine Vielzahl von unterschiedlichen Krebsarten maßgeblich verändert. Dabei werden in der klinischen Routine v. a. humanisierte Antikörper gegen Immuncheckpoints wie „cytotoxic T‑lymphocyte associated protein 4“ (CTLA-4) oder „programmed cell death 1/programmed cell death ligand 1“ (PD1/PD-L1) eingesetzt.

Fragestellung
Übersicht zur Therapielandschaft mit Immuncheckpoint-Inhibitoren bei mehrheitlich soliden Tumoren in der Onkologie.

Material und Methoden
Darstellung und Diskussion aktueller Studienresultate, Einbezug aktueller Behandlungsempfehlungen und Zulassungsindikationen.

Ergebnisse
Sieben verschiedene Immuncheckpoint-Inhibitoren werden in der Onkologie therapeutisch eingesetzt: ein Anti-CTLA-4-Antikörper, 3 Anti-PD1-Antikörper und 3 Anti-PD-L1-Antiköper. FDA-Zulassung auf dem US-Markt für 17 verschiedene Tumorentitäten und einer agnostischen Indikation (Tumoren mit defizienter Mismatch-repair-Maschinerie/hohe Mikrosatelliteninstabilität). Langzeitremissionen sind in ca. zwei Drittel der Patienten mit Tumoransprechen möglich.

Schlussfolgerungen
Nutzen der Immuncheckpoint-Inhibitoren nur für einen Teil der behandelten Patienten. Primäre und sekundäre Resistenzmechanismen erst in Anfängen verstanden. Kombinationstherapien der Immuncheckpoint-Inhibitoren mit z. B. Chemotherapie, neuen Immuncheckpoint-Inhibitoren (z. B. Anti-LAG3-Antikörper) oder gezielten Therapien (z. B. CDK4/6, PARP-Inhibitoren) zur Verbesserung der Wirksamkeit werden in klinischen Studien untersucht. Verlässliche, prädiktive Marker sind dringend erforderlich.
Reproducing macaque lateral grasping and oculomotor networks using resting state functional connectivity and diffusion tractography
Authors: Howells Henrietta , Simone Luciano , Borra Elena , Fornia Luca , Cerri Gabriella , Luppino Giuseppe 
Published: September 2020

AbstractCortico-cortical networks involved in motor control have been well defined in the macaque using a range of invasive techniques. The advent of neuroimaging has enabled non-invasive study of these large-scale functionally specialized networks in the human brain; however, assessing its accuracy in reproducing genuine anatomy is more challenging. We set out to assess the similarities and differences between connections of macaque motor control networks defined using axonal tracing and those reproduced using structural and functional connectivity techniques. We processed a cohort of macaques scanned in vivo that were made available by the open access PRIME-DE resource, to evaluate connectivity using diffusion imaging tractography and resting state functional connectivity (rs-FC). Sectors of the lateral grasping and exploratory oculomotor networks were defined anatomically on structural images, and connections were reproduced using different structural and functional approaches (probabilistic and deterministic whole-brain and seed-based tractography; group template and native space functional connectivity analysis). The results showed that parieto-frontal connections were best reproduced using both structural and functional connectivity techniques. Tractography showed lower sensitivity but better specificity in reproducing connections identified by tracer data. Functional connectivity analysis performed in native space had higher sensitivity but lower specificity and was better at identifying connections between intrasulcal ROIs than group-level analysis. Connections of AIP were most consistently reproduced, although those connected with prefrontal sectors were not identified. We finally compared diffusion MR modelling with histology based on an injection in AIP and speculate on anatomical bases for the observed false negatives. Our results highlight the utility of precise ex vivo techniques to support the accuracy of neuroimaging in reproducing connections, which is relevant also for human studies.
All-inside technique in ACL reconstruction: mid-term clinical outcomes and comparison with AM technique (Hamstrings and BpTB grafts)
Authors: Pautasso Andrea , Capella Marcello , Barberis Luca , Drocco Luca , Giai Via Riccardo , Bistolfi Alessandro , Massè Alessandro , Sabatini Luigi 
Published: September 2020

Abstract
Purpose
The aim of this study was to define the subjective and objective clinical results of all-inside surgical technique at a medium-term follow-up and to compare these results with those obtained from antero-medial (AM) ACL reconstruction technique using hamstrings (HS) or bone-patellar tendon-bone (BpTB) grafts to detect eventual superiority of one technique to another.

Methods
A retrospective analysis of routinely collected data was conducted. Inclusion criteria were ACL reconstruction through all-inside technique or AM technique with HS or BpTB performed between January 2015 and May 2018; age between 15 and 30 year old; minimum 24 months’ available follow-up. Exclusion criteria were contralateral ACL reconstruction; need for any other associated procedures during surgery. Clinical outcomes were assessed with KOOS, Lysholm, Tegner scores and KT-1000 device.

Results
According to the selection criteria, 157 patients were enrolled and divided subsequently into 3 groups: all-inside (51 patients), AM-HS (53 patients) and AM-BpTB (53 patients). A significant postoperative improvement of each score in all groups was detected. The mean KT-1000 was 3.1 ± 1.0 mm in all-inside group, while 3.3 ± 1.4 mm and 2.5 ± 0.4 mm in AM-HS and AM-BpTB groups, respectively. Comparing the results obtained, no statistically significant difference was found between the three techniques (p = 0.27). Statistically significant differences were highlighted in surgical duration: all-inside method was the longest (117′), followed by AM-BpTB surgery (101′) and AM-HS technique (87′).

Conclusions
The all-inside technique showed good postoperative results at medium-term follow-up. It could be a valuable solution for ACL reconstruction, especially in young patients due to its less invasiveness, despite surgical skills and time needed.

Levels of evidence
Level IV.
Suicidality in women with Premenstrual Dysphoric Disorder: a systematic literature review
Authors: Osborn E. , Brooks J. , O’Brien P. M. S. , Wittkowski A. 
Published: September 2020

AbstractPrevious research has identified how menstruation is an important factor in both attempted and completed suicides for women. The purpose of this review was to outline (a) the risk profile for suicidality in women who were identified to experience Premenstrual Dysphoric Disorder (PMDD), a condition characterized by severe physical and psychological changes that occur during the luteal menstrual phase, and (b) the implications of these findings for clinical practice. A systematic literature review was conducted using five databases to identify any peer-reviewed articles published between 1989 and 2019. Ten papers eligible for inclusion were identified: three pertaining to suicide cognitions, five to suicide attempts and two to both cognitions and attempts. Findings showed that suicidal thoughts, ideation, plans and attempts were strongly associated with experiences of PMDD and that these findings were independent of psychiatric co-morbidities. However, women with PMDD did not present with more severe risk profiles for suicide attempts (in terms of frequency, impulsivity and lethality) or make more frequent attempts during the luteal menstrual phase compared with suicide attempters without PMDD. Women with PMDD should be considered a high risk group for suicidality; thus, identifying and treating symptoms are vital in reducing suicide attempts. Implications for clinical practice are outlined in the discussion.
Complete positivity and distance-avoiding sets
Authors: DeCorte Evan , Filho Fernando Mário de Oliveira , Vallentin Frank 
Published: September 2020

AbstractWe introduce the cone of completely positive functions, a subset of the cone of positive-type functions, and use it to fully characterize maximum-density distance-avoiding sets as the optimal solutions of a convex optimization problem. As a consequence of this characterization, it is possible to reprove and improve many results concerning distance-avoiding sets on the sphere and in Euclidean space.
Analysis of coordinated behavior structures with multi-agent deep reinforcement learning
Authors: Miyashita Yuki , Sugawara Toshiharu 
Published: September 2020

AbstractCooperation and coordination are major issues in studies on multi-agent systems because the entire performance of such systems is greatly affected by these activities. The issues are challenging however, because appropriate coordinated behaviors depend on not only environmental characteristics but also other agents’ strategies. On the other hand, advances in multi-agent deep reinforcement learning (MADRL) have recently attracted attention, because MADRL can considerably improve the entire performance of multi-agent systems in certain domains. The characteristics of learned coordination structures and agent’s resulting behaviors, however, have not been clarified sufficiently. Therefore, we focus here on MADRL in which agents have their own deep Q-networks (DQNs), and we analyze their coordinated behaviors and structures for thepickup and floor laying problem, which is an abstraction of our target application. In particular, we analyze the behaviors around scarce resources and long narrow passages in which conflicts such as collisions are likely to occur. We then indicated that different types of inputs to the networks exhibit similar performance but generate various coordination structures with associated behaviors, such as division of labor and a shared social norm, with no direct communication.
Fast and slow curiosity for high-level exploration in reinforcement learning
Authors: Bougie Nicolas , Ichise Ryutaro 
Published: September 2020

AbstractDeep reinforcement learning (DRL) algorithms rely on carefully designed environment rewards that are extrinsic to the agent. However, in many real-world scenarios rewards are sparse or delayed, motivating the need for discovering efficient exploration strategies. While intrinsically motivated agents hold promise of better local exploration, solving problems that require coordinated decisions over long-time horizons remains an open problem. We postulate that to discover such strategies, a DRL agent should be able to combine local and high-level exploration behaviors. To this end, we introduce the concept of fast and slow curiosity that aims to incentivize long-time horizon exploration. Our method decomposes the curiosity bonus into a fast reward that deals with local exploration and a slow reward that encourages global exploration. We formulate this bonus as the error in an agent’s ability to reconstruct the observations given their contexts. We further propose to dynamically weight local and high-level strategies by measuring state diversity. We evaluate our method on a variety of benchmark environments, including Minigrid, Super Mario Bros, and Atari games. Experimental results show that our agent outperforms prior approaches in most tasks in terms of exploration efficiency and mean scores.
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation
Authors: Buday László , Vas Virág 
Published: September 2020

AbstractSomatic mutations in theRASgenes are frequent in human tumors, especially in pancreatic, colorectal, and non-small-cell lung cancers. Such mutations generally decrease the ability of Ras to hydrolyze GTP, maintaining the protein in a constitutively active GTP-bound form that drives uncontrolled cell proliferation. Efforts to develop drugs that target Ras oncoproteins have been unsuccessful. Recent emerging data suggest that Ras regulation is more complex than the scientific community has believed for decades. In this review, we summarize advances in the “textbook” view of Ras activation. We also discuss a novel type of Ras regulation that involves direct phosphorylation and dephosphorylation of Ras tyrosine residues. The discovery that pharmacological inhibition of the tyrosine phosphoprotein phosphatase SHP2 maintains mutant Ras in an inactive state suggests that SHP2 could be a novel drug target for the treatment of Ras-driven human cancers.
‘Dreaming in colour’: disabled higher education students’ perspectives on improving design practices that would enable them to benefit from their use of technologies
Authors: Seale Jane , Colwell Chetz , Coughlan Tim , Heiman Tali , Kaspi-Tsahor Dana , Olenik-Shemesh Dorit 
Published: September 2020

AbstractThe focus of this paper is the design of technology products and services for disabled students in higher education. It analyses the perspectives of disabled students studying in the US, the UK, Germany, Israel and Canada, regarding their experiences of using technologies to support their learning. The students shared how the functionality of the technologies supported them to study and enabled them to achieve their academic potential. Despite these positive outcomes, the students also reported difficulties associated with: i) the design of the technologies, ii) a lack of technology know-how and iii) a lack of social capital. When identifying potential solutions to these difficulties the disabled students imagined both preferable and possible futures where faculty, higher education institutions, researchers and technology companies are challenged to push the boundaries of their current design practices.
The risk of carbon leakage in global climate agreements
Authors: Nielsen Tobias , Baumert Nicolai , Kander Astrid , Jiborn Magnus , Kulionis Viktoras 
Published: September 2020

AbstractAlthough climate change and international trade are interdependent, policy-makers often address the two topics separately. This may inhibit progress at the intersection of climate change and trade and could present a serious constraint for global climate action. One key risk is carbon leakage through emission outsourcing, i.e. reductions in emissions in countries with rigorous climate policies being offset by increased emissions in countries with less stringent policies. We first analyze the Paris Agreement’s nationally determined contributions (NDC) and investigate how carbon leakage is addressed. We find that the risk of carbon leakage is insufficiently accounted for in these documents. Then, we apply a novel quantitative approach (Jiborn et al., 2018; Baumert et al., 2019) to analyze trends in carbon outsourcing related to a previous international climate regime—the Kyoto Protocol—in order to assess whether reported emission reductions were offset by carbon outsourcing in the past. Our results for 2000–2014 show a more nuanced picture of carbon leakage during the Kyoto Protocol than previous studies have reported. Carbon outsourcing from developed to developing countries was dominated by the USA outsourcing to China, while the evidence for other developed countries was mixed. Against conventional wisdom, we find that, in general, countries that stayed committed to their Kyoto Protocol emission targets were either only minor carbon outsourcers or actually even insourcers—although the trend was slightly negative—indicating that binding emissions targets do not necessarily lead to carbon outsourcing. We argue that multiple carbon monitoring approaches are needed to reduce the risk of carbon leakage.
Killing the Priest-King: Addressing Egalitarianism in the Indus Civilization
Authors: Green Adam S. 
Published: September 2020

AbstractThe cities of the Indus civilization were expansive and planned with large-scale architecture and sophisticated Bronze Age technologies. Despite these hallmarks of social complexity, the Indus lacks clear evidence for elaborate tombs, individual-aggrandizing monuments, large temples, and palaces. Its first excavators suggested that the Indus civilization was far more egalitarian than other early complex societies, and after nearly a century of investigation, clear evidence for a ruling class of managerial elites has yet to materialize. The conspicuous lack of political and economic inequality noted by Mohenjo-daro’s initial excavators was basically correct. This is not because the Indus civilization was not a complex society, rather, it is because there are common assumptions about distributions of wealth, hierarchies of power, specialization, and urbanism in the past that are simply incorrect. The Indus civilization reveals that a ruling class is not a prerequisite for social complexity.
Artificial neural networks test for the prediction of chemical stability of pyroclastic deposits-based AAMs and comparison with conventional mathematical approach (MLR)
Authors: Finocchiaro Claudio , Barone Germana , Mazzoleni Paolo , Sgarlata Caterina , Lancellotti Isabella , Leonelli Cristina , Romagnoli Marcello 
Published: September 2020

Abstract
The investigation on the reticulation degree of volcanic alkali-activated materials, AAMs, were experimentally determined in terms of chemico-physical properties: weight loss after leaching test in water, ionic conductivity and pH of the leachate and compressive strength. Artificial neural network (ANN) was successfully applied to predict the chemical stability of volcanic alkali-activated materials. Nine input data per each chemico-physical parameter were used to train each ANN. The training series of specific volcanic precursors were tested also for the other one. Excellent correlations between experimental and calculated data of the same precursor type were found reaching values around one. The evidence of strong effect on chemical stability of the alkaline activator SiO2/Na2O molar ratio as well as the Si/Al ratio of precursor mixtures on the reticulation degree of ghiara-based formulation with respect to volcanic ash-based materials is presented. It must be noted that such effect was much less pronounced on the compressive strength values, appearing more insensitive the molar ratio of the alkaline activator. The comparison of the ANN results with more conventional multiple linear regression (MLR) testifies the higher prediction performance of the first method. MLRs results, less significant, are useful to confirm the powerful capacity of ANNs to identify the more suitable formulation using a set of experimental AAMs. This study, as few others, on the correlation between chemical stability and compressive strength of AAMs provide a great contribution in the direction of durability and in-life mechanical performance of these class of materials.

Graphic abstract
A Stochastic Two-Scale Model for Rarefied Gas Flow in Highly Heterogeneous Porous Media
Authors: Pérez-Ràfols Francesc , Forsberg Fredrik , Hellström Gunnar , Almqvist Andreas 
Published: September 2020

AbstractThis paper presents the development of a model enabling the analysis of rarefied gas flow through highly heterogeneous porous media. To capture the characteristics associated with the global- and the local-scale topology of the permeable phase in a typical porous medium, the heterogeneous multi-scale method, which is a flexible framework for constructing two-scale models, was employed. The rapid spatial variations associated with the local-scale topology are accounted for stochastically, by treating the permeability of different local-scale domains as a random variable. The results obtained with the present model show that an increase in the spatial variability in the heterogeneous topology of the porous medium significantly reduces the relevance of rarefaction effects. This clearly shows the necessity of considering a realistic description of the pore topology and questions the applicability of the results obtained for topologies exhibiting regular pore patterns. Although the present model is developed to study low Knudsen number flows, i.e. the slip-flow regime, the same development procedure could be readily adapted for other regimes as well.
Toxicological analysis of satratoxins, the main toxins in the mushroom Trichoderma cornu-damae, in human serum and mushroom samples by liquid chromatography–tandem mass spectrometry
Authors: Ohta Hikoto , Watanabe Daisuke , Nomura Chie , Saito Daichi , Inoue Koichi , Miyaguchi Hajime , Harada Shuichi , Aita Yuji 
Published: September 2020

Abstract
Purpose
Many poisoning cases involving the deadly toxic mushroom Trichoderma cornu-damae have been reported, but there are very few reports on toxicological analysis of the poisoning. In this study, a simple and sensitive method was developed for detecting and quantifying satratoxins, which are the main toxins found in T. cornu-damae, in human serum and mushroom samples.

Methods
The four main toxins, namely, satratoxin H and its 12′-acetate, 13′-acetate and 12′,13′-diacetate, were isolated from T. cornu-damae and used as analytical standards. These standards were spiked into human serum and effective methods were developed for extraction and detection/quantification using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Quantification of satratoxins in T. cornu-damae samples was performed by the standard addition method.

Results
Although satratoxins, which have neutral terpene structures, showed very low sensitivities in conventional LC–MS/MS analysis, they could be detected with enough sensitivity by our developed method. In human serum, the limit of detection was 0.1 ng/mL and the limit of quantification was 1 ng/mL for all four satratoxins. The recovery rate ranged from 70.5 to 86.6%, and the coefficients of determination for calibration curves were > 0.999. Satratoxins in T. cornu-damae samples were also well detected and quantified with coefficients of determination for calibration curves of > 0.997 and intraday/interday precision (relative standard deviation) ranging from 2.98 to 10.3%.

Conclusions
To our knowledge, this is the first report of toxicological analysis of satratoxins using analytical standards.