bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative difference among 27 functional measures in patients with knee osteoarthritis: an exploratory cross-sectional case-control study
Authors: Vårbakken K. , Lorås H. , Nilsson K. G. , Engdal M. , Stensdotter A. K. 
Published: October 2019

Abstract

Background
To raise the effectiveness of interventions, clinicians should evaluate important biopsychosocial aspects of the patient’s situation. There is limited knowledge of which factors according to the International Classification of Function, Disability, and Health (ICF) are most deviant between patients with knee osteoarthritis (KOA) and healthy individuals. To assist in measures’ selection, we aimed to quantify the differences between patients with KOA and healthy controls on various measures across the ICF dimensions of body function, activity, and participation.

Methods
We performed an exploratory cross-sectional case-control study. In total, 28 patients with mild-to-moderate KOA (mean age 61 years, 64% women) referred by general physicians to a hospital’s osteoarthritis-school, and 31 healthy participants (mean age 55 years, 52% women), volunteered. We compared between-group differences on 27 physical and self-reported measures derived from treatment guidelines, trial recommendations, and trial/outcome reviews. Independent t-test, Chi-square, and Mann-Whitney U test evaluated the significance for continuous parametric, dichotomous, and ordinal data, respectively. For parametric data, effect sizes were calculated as Cohen’s d. For non-parametric data, ds were estimated by p-values and sample sizes according to statistical formulas. Finally, all ds were ranked and interpreted after Hopkins’ scale. An age-adjusted sensitivity-analysis on parametric data validated those conclusions.

Results
Very large differences between patients and controls were found on the Pain numeric rating scale1, the Knee Injury and Osteoarthritis Scale (KOOS, all subscales)2, as well as the Örebro Musculoskeletal psychosocial scale3 (P < 0.0001). Large differences were found on the Timed 10-steps-up-and-down stair climb test4 and Accelerometer registered vigorous-intensity physical activity in daily life5 (P < 0.001). Respectively, these measures clustered on ICF as follows: 1body function, 2all three ICF-dimensions, 3body function and participation, 4activity, and 5participation.

Limitations
The limited sample excluded elderly patients with severe obesity.

Conclusions
Very large differences across all ICF dimensions were indicated for the KOOS and Örebro questionnaires together for patients aged 45–70 with KOA. Clinicians are suggested to use them as means of selecting supplementary measures with appropriate discriminative characteristics and clear links to effective therapy. Confirmative studies are needed to further validate these explorative and partly age-unadjusted conclusions.
Significant risk factors for malignant transformation of ovarian endometrioma during dienogest treatment: a case report and retrospective study
Authors: Honda Michiko , Isono Wataru , Tsuchiya Akira , Saito Ako , Tsuchiya Hiroko , Matsuyama Reiko , Fujimoto Akihisa , Nishii Osamu 
Published: October 2019

Abstract

Background
To determine the prevalence of and risk factors for malignant transformation of ovarian endometrioma during dienogest therapy, which is very rare, we examined multiple cases of malignant transformation of ovarian endometrioma during dienogest therapy and performed a multivariate analysis of the records in our hospital.

Methods
The medical records of 174 patients who underwent DNGT for the treatment of OMA from June 1, 2011, to May 31, 2018, were reviewed retrospectively with the approval of the Human Ethical Committee of the University of Teikyo Hospital. And we provided one representative case of MT with obtaining written informed consent. To assess the effects of six representative factors, including advanced age, parity, surgical history, and endometrial cyst characteristics (including 3 factors), on the possibility of malignant transformation, we performed a multivariate logistic regression analysis.

Results
Of the 174 cases, 4 were diagnosed with malignant transformation, and these cases are reported. In the multivariate analysis, advanced age (P = 0.0064), nullipara (P = 0.0322), and enlargement (P = 0.0079) showed significant differences for malignant transformation occurrence. All 4 malignant transformation cases were among the 19 patients who had all of these 3 factors.

Conclusions
For a more accurate determination of the treatment approach, a larger sample size will be needed to determine the risk factors for malignant transformation during dienogest therapy.
Convolutional technique for enhancing security in wireless sensor networks against malicious nodes
Authors: Alghamdi Turki Ali 
Published: October 2019

Abstract
Wireless sensor networks (WSNs) comprise tiny devices known as sensors. These devices are frequently employed in short-range communications and can perform various operations such as monitoring, collecting, analyzing, and processing data. WSNs do not require any infrastructure, are reliable, and can withstand adverse conditions. Sensor networks are autonomous structures in which the sensor nodes can enter or leave the network at any time instant. If the entering node is attacker node it will monitor the network operation and can cause security issues in the network that can affect communication. Existing literature presents security improvements in such networks in the form of cryptography, asymmetric techniques, key distribution, and various protocols. However, these techniques may not be effective in the case of autonomous structures and can increase computational complexity. In this paper, a convolutional technique (CT) is proposed that generates security bits using convolutional codes to prevent malicious node attacks on WSNs. Different security codes are generated at different hops and the simulation results demonstrate that the proposed technique enhances network security and reduces computational complexity compared to existing approaches.
An embedded method for gene identification problems involving unwanted data heterogeneity
Authors: Lu Meng 
Published: October 2019

AbstractBackgroundModern applications such as bioinformatics collecting data in various ways can easily result in heterogeneous data. Traditional variable selection methods assume samples are independent and identically distributed, which however is not suitable for these applications. Some existing statistical models capable of taking care of unwanted variation were developed for gene identification involving heterogeneous data, but they lack model predictability and suffer from variable redundancy.ResultsBy accounting for the unwanted heterogeneity effectively, our method have shown its superiority over several state-of-the art methods, which is validated by the experimental results in both unsupervised and supervised gene identification problems. Moreover, we also applied our method to a pan-cancer study where our method can identify the most discriminative genes best distinguishing different cancer types.ConclusionsThis article provides an alternative gene identification method that can accounting for unwanted data heterogeneity. It is a promising method to provide new insights into the complex cancer biology and clues for understanding tumorigenesis and tumor progression.
Clinical application of injectable growth factor for bone regeneration: a systematic review
Authors: Kuroda Yutaka , Kawai Toshiyuki , Goto Koji , Matsuda Shuichi 
Published: October 2019

Abstract
Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has focused on three primary approaches, which are expected to increase in popularity: cell therapy, proteins, and artificial materials. Among these, the local injection of a gelatin hydrogel impregnated with the protein fibroblast growth factor (FGF)-2 is a biomaterial technique that has been developed in Japan. We have previously reported the efficacy of gelatin hydrogel containing injectable FGF-2 for the regenerative treatment of osteonecrosis of the femoral head. Injectable growth factors will probably be developed in the future and gain popularity as a medical approach in various fields as well as orthopedics. Several clinical trials have already been conducted and have focused on this technique, reporting its efficacy and safety. To date, reports of the clinical application of FGF-2 in revascularization for critical limb ischemia, treatment of periodontal disease, early bone union for lower limb fracture and knee osteotomy, and bone regeneration for osteonecrosis of the femoral head have been based on basic research conducted in Japan. In the present report, we present an extensive review of clinical applications using injectable growth factors and discuss the associated efficacy and safety of their administration.
The efficacy of pre-emptive analgesia on pain management in total knee arthroplasty: a mini-review
Authors: Xu Jianda , Li Huan , Zheng Chong , Wang Bin , Shen Pengfei , Xie Zikang , Qu Yuxing 
Published: October 2019

Abstract
Total knee arthroplasty (TKA) is considered a cost-effective and efficacious treatment for patients with end-stage knee arthritis. Meanwhile, TKA has been regarded as one of the most painful orthopaedic surgeries. Pain control after TKA remains a challenging task. Many analgesic innovations are used to reduce the level of pain, but none has been proven to be the optimum choice till now. Multimodal analgesia incorporates the use of analgesic adjuncts with different mechanisms of action to enhance postoperative pain management. This approach is a preferable choice in relieving postoperative pain with minimum side effects. This paper aims to review pre-emptive analgesia for pain management in TKA. We reviewed the application of pre-emptive analgesia, its physiological mechanism, and the techniques.
Principles and applications of optogenetics in developmental biology
Authors: Krueger Daniel , Izquierdo Emiliano , Viswanathan Ranjith , Hartmann Jonas , Pallares Cartes Cristina , De Renzis Stefano 
Published: October 2019

ABSTRACT
The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application in developmental biology and in the nascent field of synthetic morphogenesis.
Case Report: Xanthogranulomatous prostatitis, a difficult differential diagnosis of prostate adenocarcinoma
Authors: El Moussaoui Reda , El Moussaoui Ali , Dakir Mohamed , Benkirane Amal 
Published: October 2019

Background: Xanthogranulomatous prostatitis is a rare benign inflammatory process of the prostate. Clinical, biochemical and imaging similarities make xanthogranulomatous prostatitis a difficult differential diagnosis of prostatic adenocarcinoma. Case presentation: We report the case of a 62 year-old diabetic patient, with 3 months of lower urinary tract symptoms. On digital rectal examination, the prostate was hard and nodular. Initial prostate-specific antigen (PSA) was 43.97 ng/mL, with urine analysis and transabdominal ultrasonography not showing any alterations. A multiparametric magnetic resonance imaging (mpMRI) of the prostate was performed and showed two foci that were classified as PI-RADS 4 lesions. A transrectal ultrasound guided prostate biopsy was then realized. After an initial suspicion of prostatic adenocarcinoma, on clinical, biochemical and radiological grounds, histopathological examination revealed a suppurated xanthogranulomatous prostatitis, with no evidence of malignancy. Conclusions: Xanthogranulomatous prostatitis is an uncommon benign inflammatory condition of the prostate that can clinically, biochemically and even radiologically simulate prostatic adenocarcinoma. We advise that if an older male with low urinary tract symptoms and a hard nodular prostate on digital rectal examination presents, the first diagnosis that one should think of is prostate adenocarcinoma, especially if PSA is high. However, only histopathological examination can differentiate with certitude between these two pathologies and is therefore essential for the diagnosis of xanthogranulomatous prostatitis.
Relações Internacionais na Extensão Universitária: o tripé do ensino, pesquisa e extensão levado à educação básica | International Relations in the Academic Outreach Project: the tripod of teaching, research and outreach projects led to the secondary education
Authors: Maia Marrielle , Araújo Ana Beatriz , Brunetta Pedro Costa 
Published: October 2019

A exigência legal de que os cursos de graduação reservem 10% de sua carga horária para a realização de atividades de extensão coloca para os cursos de Relações Internacionais o desafio de repensar suas práticas de extensão. O presente artigo busca contribuir com esse movimento de reflexão ao apresentar uma ação de extensão que leva para a educação básica o debate sobre o papel das organizações internacionais e a relação entre o global e local. A proposta é inovadora já na sua concepção, ou seja, do preparo dos alunos para a extensão na disciplina “Economia e Organizações Internacionais”, onde são empregadas metodologias ativas (role playing). Na parceria com as instituições de educação básica, as atividades de simulação vivenciadas pelos alunos da graduação são adaptadas para a realidade da educação básica junto com os professores de instituições parceiras. Após essa adaptação, os discentes da graduação ministram a atividade aos estudantes do ensino básico.Palavras-chave: Relações Internacionais; Ensino, Pesquisa e Extensão; Organizações Internacionais ABSTRACTThe Brazilian legal exigence of setting 10% of the graduation courses’ credits to outreach activities poses the challenge of rethinking their practices for the graduations courses in International Relations. The present article contributes to that reflexion by presenting an outreach activity that takes to elementary schools the debate on international organizations and the connections between global and local. The proposition is innovative in its conception: from the activity preparation of the undergraduate students inside the “Economy and International Organizations” discipline, where active methodologies (role playing) are applied. In the partnership with elementary schools, the modeling activities experienced by the undergraduate students are adapted to the school reality jointly with teachers from the partner school. After the adaptation, the undergraduate students impart the activity to the elementary students.Keywords: International Relations; Teaching, researching and outreach; International Organizations. Recebido em: 06 nov.2018 | Aceito em: 24 ago.2019
Más que adobes. La construcción con tierra durante los siglos IV-III a.C. en el Área 11 de Giribaile (Vilches, Jaén)
Authors: Ortiz Villarejo Antonio Jesús , Gutiérrez Soler Luis María , Alejo Armijo María 
Published: October 2019

La campaña de excavación arqueológica desarrollada durante el año 2014 en la meseta de Giribaile documentó un espacio de almacenaje, el Área 11, en excelente estado de conservación que, entre otros materiales, ha proporcionado un total de 342 fragmentos de material de construcción divididos en los grupos: ladrillo, argamasa, revoque e indeterminados. La generación de una base de datos para su gestión y análisis estadístico así como la realización de los estudios de DRX composicional, análisis de carbonatos y pruebas de resistencia, han permitido avanzar tanto en el conocimiento del proceso de fabricación, cocción en frío, como caracterizar de manera precisa su composición y la realización de un catálogo de estas piezas que puede ser una nueva referencia en este campo.
The CDC PNU-1 criteria for diagnosis of ventilator-associated pneumonia
Authors: Ningtiar Hapsari Widya , Lestari Dwi Putri , Kusumastuti Neurinda Permata , Setyaningtyas Arina , Setyoningrum Retno Asih , Dharmawati Ira , Azis Abdul Latief 
Published: October 2019

Background Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the pediatric intensive care unit (PICU), with mortality rates of up to 50%. Post-mortem pulmonary examination is considered to be the gold standard for diagnosis of VAP, but is impossible for routine application. The sensitivity and specificity of Clinical Pulmonary Infection Score (CPIS) are considered to be similar to the those of the gold standard, but the Centers for Disease Control and Prevention PNU-1 (CDC PNU-1) is simpler and not invasive, compared to the CPIS.
Objective To evaluate the level of agreement between CDC PNU-1 and CPIS criteria in diagnosing VAP.
Methods This cross-sectional study was conducted in the PICU at Dr. Soetomo Hospital, Surabaya from June to October 2018. Subjects were children aged 1 month–18 years who had been intubated for more than 48 hours. The VAP diagnoses were made by CDC PNU-1 and CPIS criteria. The level of agreement between the two methods was evaluated by Cohen’s Kappa test using SPSS Statistics Base 21.0 software.
Results hirty-six subjects were evaluated using CDC PNU-1 and CPIS criteria. Subjects’ mean age was 3.5 (SD 4.7) years. Amongst 19 patients with VAP, 14 were diagnosed by CPIS criteria and 17 were diagnosed by CDC PNU-1 criteria. The level of agreement between the CDC PNU-1 and CPIS criteria was good (Kappa 0.61; 95%CI 0.31 to 0.83). The CDC PNU-1 had sensitivity 0.85, specificity 0.77, positive predictive value (PPV) 0.70, and negative predictive value (NPV) 0.89.
Conclusion The CDC PNU-1 criteria has a good level of agreement with CPIS criteria in diagnosing VAP.
Second language English listeners’ relative processing of coherence-based and frequency-based formulas: A corpus-based study
Authors: Yeldham Michael 
Published: October 2019

AbstractThis study investigated L2 English listeners’ processing of formulas, in terms of the impact of two different factors inherent in these formulas. One was the formulas’ level of coherence and the other was the formulas’ level of frequency. High-coherence formulas are considered to have specialized meanings, while high-frequency formulas are considered to be less specialized in meaning, commonly being composed of relatively simple words that often co-occur in speech. In previous research, in an academic context, Ellis, Simpson-Vlach and Maynard (2008. Formulaic language in native and second-language speakers: Psycholinguistics, corpus linguistics, and TESOL. TESOL Quarterly 41. 375–396. doi:10.1002/j.1545-7249.2008.tb00137.x) had found that a high level of coherence was the main factor facilitating L1 users’ receptive processing of formulas, while a high level of frequency was the main factor facilitating advanced L2 users’ receptive processing of formulas. Ellis, Simpson-Vlach and Maynard (2008. Formulaic language in native and second-language speakers: Psycholinguistics, corpus linguistics, and TESOL. TESOL Quarterly 41. 375–396. doi:10.1002/j.1545-7249.2008.tb00137.x), from a usage-based perspective, attributed these differences mainly to the greater length of time the L1 users had spent in learning formulas. Consequently, the current study investigated whether these processing differences between the two user groups in an academic context (seen as a possible developmental trend) would be apparent between proficient and less-proficient L2 listeners in a relatively less-challenging, general English environment. The study was considered important for possibly signaling the types of aural receptive formulas to foreground by L2 general English instructors and materials designers. The research examined two groups of L2 learners, one advanced and the other intermediate level, while they listened to four texts. A paused transcription technique elicited the listeners’ identification of targeted segments from the texts, many of which were classified through corpus analysis as containing more/less-coherent formulas or more/less-frequent formulas. Examination of how these formula types were processed by both proficiency groups, however, did not find major differences between the groups in their processing of the different formula types, and thus little evidence of a possible formula developmental trend.
Development and evaluation of an element-tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection: can we apply the new assay in the clinical laboratory?
Authors: Jiang Wencan , Sun Gongwei , Wen Xinyu , Men Shasha , Cui Wenbin , Jing Miao , Jia Xingwang , Hu Zhian , Pu Danna , Zhang Sichun , Yuan Xiaozhou , Liu Xiaoting , Zhang Xinrong , Wang Chengbin 
Published: October 2019

Abstract

Introduction
Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the requirements of the clinical laboratory.

Methods
Carcinoembryonic antigen (CEA) was chosen for analysis using the proposed method. A systematic evaluation of the proposed assay was carried out according to the Clinical and Laboratory Standards Institute (CLSI). The 469 clinical samples were analyzed using the new method and compared with the electrochemiluminescent immunoassay (ECLIA) method.

Results
The measurement range of the assay was 1–900 ng/mL, with a detection limit of 0.83 ng/mL. The inter-assay and intra-assay imprecision were 4.67% and 5.38% with high concentration samples, and 9.27% and 17.64% with low concentration samples, respectively. The cross-reactivity (%) for different antigens was less than 0.05%, and the recovery was between 94% and 108%. Percentage deviation of all the dilutions was less than 12.5% during linearity estimation. The interference bias caused by different substances was less than 10%. The reference interval of the assay was 0–4.442 ng/mL. Comparison with the commercial ECLIA method for clinical sample detection, the proposed method showed a correlation of 0.9878 and no significant differences between the methods were observed (p = 0.6666).

Conclusions
The ICP-MS based immunoassay was successfully developed, and the analytical performance of the assay met the requirements of the CLSI, which fully proved the clinical transferability and application of the new method.
Deformation of rotating two-layer curved composite beams
Authors: Ecsedi István , Lengyel Ákos József 
Published: October 2019

Abstract
An analytical solution is presented for the determination of the deformation of rotating two-layer composite beams. The direction of axis of rotation is vertical and the speed of rotation is constant. The axis of rotation is in the plane of symmetry of curved beam. The source of the in-plane deformation is the stationary rotation of the curved beam. The plane of the curvature is the symmetry plane of the curved beam for its material, geometrical and supporting properties. Assumed form of the displacement field meets the prescriptions of the classical Euler-Bernoulli beam theory. Examples illustrate the applications of the presented analytical solution.