bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC–MS/MS Reference Method
Authors: Korecka Magdalena , Figurski Michal J , Landau Susan M , Brylska Magdalena , Alexander Jacob , Blennow Kaj , Zetterberg Henrik , Jagust William J , Trojanowski John Q , Shaw Leslie M ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2020

Abstract

Background
Cerebrospinal fluid (CSF) amyloid-β1-42 (Aβ42) reliably detects brain amyloidosis based on its high concordance with plaque burden at autopsy and with amyloid positron emission tomography (PET) ligand retention observed in several studies. Low CSF Aβ42 concentrations in normal aging and dementia are associated with the presence of fibrillary Aβ across brain regions detected by amyloid PET imaging.

Methods
An LC–MS/MS reference method for Aβ42, modified by adding Aβ40 and Aβ38 peptides to calibrators, was used to analyze 1445 CSF samples from ADNIGO/2 participants. Seventy runs were completed using 2 different lots of calibrators. For preparation of Aβ42 calibrators and controls spiking solution, reference Aβ42 standard with certified concentration was obtained from EC-JRC-IRMM (Belgium). Aβ40 and Aβ38 standards were purchased from rPeptide. Aβ42 calibrators’ accuracy was established using CSF-based Aβ42 Certified Reference Materials (CRM).

Results
CRM-adjusted Aβ42 calibrator concentrations were calculated using the regression equation Y (CRM-adjusted) = 0.89X (calibrators) + 32.6. Control samples and CSF pools yielded imprecision ranging from 6.5 to 10.2% (Aβ42) and 2.2 to 7.0% (Aβ40). None of the CSF pools showed statistically significant differences in Aβ42 concentrations across 2 different calibrator lots. Comparison of Aβ42 with Aβ42/Aβ40 showed that the ratio improved concordance with concurrent [18F]-florbetapir PET as a measure of fibrillar Aβ (n = 766) from 81 to 88%.

Conclusions
Long-term performance assessment substantiates our modified LC–MS/MS reference method for 3 Aβ peptides. The improved diagnostic performance of the CSF ratio Aβ42/Aβ40 suggests that Aβ42 and Aβ40 should be measured together and supports the need for an Aβ40 CRM.
A Guess-And-Determine Attack On SNOW-V Stream Cipher
Authors: Jiao Lin , Li Yongqiang , Hao Yonglin 
Published: January 2020

Abstract
The 5G mobile communication system is coming with a main objective, known also as IMT-2020, that intends to increase the current data rates up to several gigabits per second. To meet an accompanying demand of the super high-speed encryption, EIA and EEA algorithms face some challenges. The 3GPP standardization organization expects to increase the security level to 256-bit key length, and the international cryptographic field responds actively in cipher designs and standard applications. SNOW-V is such a proposal offered by the SNOW family design team, with a revision of the SNOW 3G architecture in terms of linear feedback shift register (LFSR) and finite state machine (FSM), where the LFSR part is new and operates eight times the speed of the FSM, consisting of two shift registers and each feeding into the other, and the FSM increases to three 128-bit registers and employs two instances of full AES encryption round function for update. It takes a 128-bit IV, employs 896-bit internal state and produces 128-bit keystream blocks. The result is competitive in pure software environment, making use of both AES-NI and AVX acceleration instructions. Thus, the security evaluation of SNOW-V is essential and urgent, since there is scarcely any definite security bound for it. In this paper, we propose a byte-based guess-and-determine attack on SNOW-V with complexity $2^{406}$ using only seven keystream blocks. We first improve the heuristic guessing-path auto-searching algorithm based on dynamic programming by adding initial guessing set, which is iteratively modified by sieving out the unnecessary guessing variables, in order to correct the guessing path according to the cipher structure and finally launch smaller guessing basis. For the specific design, we split all the computing units into bytes and rewrite all the internal operations correspondingly. We establish a backward-clock linear equation system according to the circular construction of the LFSR part. Then we further simplify the equations to adapt to the input requirements of the heuristic guessing-path auto-searching algorithm. Finally, the derived guessing path needs modification for the pre-simplification and post-reduction. This is the first complete guess-and-determine attack on SNOW-V as well as the first specific security evaluation to the full cipher.
Integrating Context to Preferences and Goals for Goal-oriented Adaptability of Software Systems
Authors: Botangen Khavee Agustus , Yu Jian , Yeap Wai Kiang , Sheng Quan Z 
Published: January 2020

AbstractModern software systems are continuously seeking for adaptability realizations, to generate better fit behaviours in response to domain changes. Requirements variability motivates adaptability; hence, understanding the influence of the domain changes, i.e. context variability, to requirements variability is necessary. In this paper, we propose an approach for context-based requirements variability analysis in the goal-oriented requirements modelling. We define contextual goals and contextual preferences to specify the relationships of contexts with requirements and preferences, respectively. Given a requirements problem represented through a goal model, we use the contextual goals to derive applicable solutions at a given situation. Then, from those applicable solutions, we use the contextual preferences as criteria for evaluating and selecting the ones that would best satisfy stakeholder priorities. To support our variability analysis, we develop a tool to automate the derivation and evaluation of the solutions. We further demonstrate the use of our approach in detecting modelling errors and validating the impact of prioritizations, leading to improvements in the requirements specifications. Our approach broadens the scope of requirements variability by weaving context variability with both stakeholder goals and preferences, in order to sufficiently represent the adaptability needs of software systems where contextual changes are commonplace.
The relevance of depressive symptoms for the outcome of patients receiving vitamin K antagonists: results from the thrombEVAL cohort study
Authors: Michal Matthias , Eggebrecht Lisa , Göbel Sebastian , Panova-Noeva Marina , Nagler Markus , Arnold Natalie , Lauterbach Michael , Bickel Christoph , Wiltink Jörg , Beutel Manfred E , Münzel Thomas , Wild Philipp S , Prochaska Jürgen H 
Published: January 2020

Abstract

Aims
Although depressive symptoms are highly prevalent in patients receiving oral anticoagulation (OAC), the relevance of depression for the outcome of anticoagulated individuals is unknown.

Methods and results
We analysed data from the multicentre cohort study thrombEVAL (NCT01809015) investigating the efficacy of OAC with vitamin K antagonists. There was an independent study monitoring, and an independent review panel assessed the endpoints. Out of n = 1558 participants, information about depressive symptoms, as measured by the two-item screener of the patient health questionnaire (PHQ-2), was available in n = 1405 individuals. The mean follow-up period was 28.04 months, with a standard deviation of 11.52 months. In multivariable Cox regression analysis, baseline PHQ-2 sum score was a strong and robust predictor of clinically relevant bleeding [hazard ratio (HR) 1.13, 95% confidence interval 1.03–1.24; P = 0.011] and all-cause mortality (HR 1.18, 1.08–1.28; P = 0.001) independent of age, sex, high school graduation, partnership, clinical profile, intake of serotonin reuptake inhibitors, and quality of OAC therapy. Individuals with clinically significant depressive symptoms (PHQ-2 ≥ 3) had a 57% increased risk for clinically relevant bleeding (fully adjusted HR 1.57, 1.08–2.28) and 54% greater risk for death (fully adjusted HR 1.54, 1.09–2.17). There was no association of depressive symptoms with thromboembolic events. For hospitalization, individuals with depressive symptoms (PHQ-2 ≥ 3) did not experience an elevated risk in the fully adjusted model (HR 1.08, 0.86–1.35; P = 0.52).

Conclusion
Assessment of depression by the PHQ-2 provided independent long-term prognostic information beyond common biomedical risk factors. These findings highlight the need for targeting depressive symptoms in the management of patients receiving OAC therapy.
Geometry of the pulmonary arteries before the Fontan operation: can we influence it during the Norwood procedure?
Authors: Januszewska Katarzyna , Nawrocki Pawel , Lehner Anja , Stegger Julia , Kleinerueschkamp Felix , Malec Edward 
Published: January 2020

Abstract

OBJECTIVES
The right ventricle-to-pulmonary artery (RV-PA) shunt provides stable haemodynamics after the Norwood procedure but can influence development of the central pulmonary arteries (PAs). The goal of this study was to analyse the geometry of the central PAs in children with hypoplastic left heart syndrome before the Fontan operation with respect to the RV-PA shunt site and the type of the second-stage operation.

METHODS
A total of 161 children with hypoplastic left heart syndrome, median age 2.7 (range 1.3–9.8) years and median weight 12.7 (range 7.6–26.1) kg, underwent the Fontan operation after having had the Norwood procedure with an RV-PA shunt. The patients were divided into 2 groups: left-sided RV-PA (L-RV-PA) (n = 129) with the shunt on the left and right-sided RV-PA (n = 32) with the shunt on the right side of the neoaorta. Angiographic data obtained before the Fontan and all cardiac catheterization interventions were analysed retrospectively.

RESULTS
Between the second and third stages, as well as directly before the Fontan operation, the L-RV-PA group required more PA catheter interventions (P = 0.001 and P = 0.03). In this group, the minimal left PA diameter was smaller than that in the R-RV-PA group (P = 0.021). Leaving the shunt open until the Fontan operation increased the rate of PA interventions in the L-RV-PA group (P = 0.001), but there is no evidence of the impact on the development of the left PAs (P = 0.075). There is also no evidence that the type of the second-stage procedure influences the intervention rate before the Fontan procedure (P = 0.14).

CONCLUSIONS
Children who have the L-RV-PA shunt require more PA catheter interventions. The right-sided RV-PA shunt and the subsequent Glenn anastomosis in the place of the shunt are associated with distortion-free and more symmetrical development of the central PAs.
Comparative Plastid Genomics of Cryptomonas Species Reveals Fine-Scale Genomic Responses to Loss of Photosynthesis
Authors: Tanifuji Goro , Kamikawa Ryoma , Moore Christa E , Mills Tyler , Onodera Naoko T , Kashiyama Yuichiro , Archibald John M , Inagaki Yuji , Hashimoto Tetsuo 
Published: January 2020

AbstractLoss of photosynthesis is a recurring theme in eukaryotic evolution. In organisms that have lost the ability to photosynthesize, nonphotosynthetic plastids are retained because they play essential roles in processes other than photosynthesis. The unicellular algal genus Cryptomonas contains both photosynthetic and nonphotosynthetic members, the latter having lost the ability to photosynthesize on at least three separate occasions. To elucidate the evolutionary processes underlying the loss of photosynthesis, we sequenced the plastid genomes of two nonphotosynthetic strains, Cryptomonas sp. CCAC1634B and SAG977-2f, as well as the genome of the phototroph Cryptomonas curvata CCAP979/52. These three genome sequences were compared with the previously sequenced plastid genome of the nonphotosynthetic species Cryptomonas paramecium CCAP977/2a as well as photosynthetic members of the Cryptomonadales, including C. curvata FBCC300012D. Intraspecies comparison between the two C. curvata strains showed that although their genome structures are stable, the substitution rates of their genes are relatively high. Although most photosynthesis-related genes, such as the psa and psb gene families, were found to have disappeared from the nonphotosynthetic strains, at least ten pseudogenes are retained in SAG977-2f. Although gene order is roughly shared among the plastid genomes of photosynthetic Cryptomonadales, genome rearrangements are seen more frequently in the smaller genomes of the nonphotosynthetic strains. Intriguingly, the light-independent protochlorophyllide reductase comprising chlB, L, and N is retained in nonphotosynthetic SAG977-2f and CCAC1634B. On the other hand, whereas CCAP977/2a retains ribulose-1,5-bisphosphate carboxylase/oxygenase-related genes, including rbcL, rbcS, and cbbX, the plastid genomes of the other two nonphotosynthetic strains have lost the ribulose-1,5-bisphosphate carboxylase/oxygenase protein-coding genes.
Almost Sure Local Well-Posedness for a Derivative Nonlinear Wave Equation
Authors: Bringmann Bjoern 
Published: January 2020

Abstract
We study the derivative nonlinear wave equation $- \partial _{tt} u + \Delta u = |\nabla u|^2$ on $\mathbb{R}^{1 +3}$. The deterministic theory is determined by the Lorentz-critical regularity $s_L = 2$, and both local well-posedness above $s_L$ as well as ill-posedness below $s_L$ are known. In this paper, we show the local existence of solutions for randomized initial data at the super-critical regularities $s\geqslant 1.984$. In comparison to the previous literature in random dispersive equations, the main difficulty is the absence of a (probabilistic) nonlinear smoothing effect. To overcome this, we introduce an adaptive and iterative decomposition of approximate solutions into rough and smooth components. In addition, our argument relies on refined Strichartz estimates, a paraproduct decomposition, and the truncation method of de Bouard and Debussche.
A Lack of Legal Protection and Limited Ways Out: How Asylum Seekers Cope with Liminality on Greek Islands: Lesbos and Chios
Authors: Tunaboylu Muzaffer Sevda , van Liempt Ilse 
Published: January 2020

Abstract
This article focuses on the experiences and coping strategies of those who have sought asylum on the Greek islands of Lesbos and Chios after the EU–Turkey deal of March 2016. Based on semi-structured interviews with asylum seekers and participatory observations on the two islands between July and August 2017, we explore the impact of the EU–Turkey deal on asylum seekers and how they cope with it. Although the implementation of the deal has an effect on their ability to cross irregularly to Europe, our findings show that many asylum seekers still come to the islands, aspiring to move on and, in some cases, succeeding. A combination of factors facilitates or hinders a secondary movement from the islands despite the structural constraints. We saw that, often, those with a genuine asylum claim choose to move on despite the risk of losing their legal status. In this way, our research challenges the discursive categorization of those who wait through containment as ‘deserving refugees’ and those who move on as ‘undeserving migrants’ and provides a critical analysis of current European migration policies.
What Happened to Children Who Returned from the Lord’s Resistance Army in Uganda?
Authors: Allen Tim , Atingo Jackline , Atim Dorothy , Ocitti James , Brown Charlotte , Torre Costanza , Fergus Cristin A , Parker Melissa 
Published: January 2020

AbstractIn northern Uganda, more than 50,000 people were recruited by the Lord’s Resistance Army (LRA) between the late 1980s and 2004, mostly by force. Around half of those taken were children (under 18 years old). A large number were never seen by their families again, but more than 20,000 returned through aid-financed reception centres. Endeavours were made to reunite them with their relatives, who were mostly living in insecure displacement camps. Relatively few were subsequently visited, even after the fighting ended in 2006. Thousands of vulnerable children were largely left to their own devices. This article draws on research carried out in 2004–06 and from 2012 to 2018, and compares findings with other publications on reintegration in the region. It argues that implementing best-practice guidelines for relocating displaced children with their immediate relatives had negative consequences. The majority of children who passed through a reception centre are now settled as young adults on ancestral land, where they are commonly abused because of their LRA past. With few exceptions, it is only those who spent a long period with the LRA and who are not living on ancestral land who have managed to avoid such experiences.
Thermography methods to assess stomatal behaviour in a dynamic environment
Authors: Vialet-Chabrand Silvere , Lawson Tracy 
Published: January 2020

Abstract
Although thermography allows rapid, non-invasive measurements of large numbers of plants, it has not been used extensively due to the difficulty in deriving biologically relevant information such as leaf transpiration (E) and stomatal conductance (gsw) from thermograms. Methods normalizing leaf temperature using temperatures from reference materials (e.g. with and without evaporative flux) to generate stress indices are generally preferred due to their ease of use to assess plant water status. Here, a simplified method to solve dynamic energy balance equations is presented, which enables the calculation of ‘wet’ and ‘dry’ leaf temperatures in order to derive stress indices, whilst providing accurate estimates of E and gsw. Comparing stress indices and gas exchange parameters highlights the limitation of stress indices in a dynamic environment and how this problem can be overcome using artificial leaf references with known conductance. Additionally, applying the equations for each pixel of a thermogram to derive the rapidity of stomatal response over the leaf lamina in wheat revealed the spatial heterogeneity of stomatal behaviour. Rapidity of stomatal movements is an important determinant of water use efficiency, and our results showed ‘patchy’ responses that were linked to both the spatial and temporal response of gsw.
Probabilistic justification logic
Authors: Kokkinis Ioannis , Ognjanović Zoran , Studer Thomas 
Published: January 2020

Abstract
We present a probabilistic justification logic, $\mathsf{PPJ}$, as a framework for uncertain reasoning about rational belief, degrees of belief and justifications. We establish soundness and strong completeness for $\mathsf{PPJ}$ with respect to the class of so-called measurable Kripke-like models and show that the satisfiability problem is decidable. We discuss how $\mathsf{PPJ}$ provides insight into the well-known lottery paradox.
The complexity of disjunction in intuitionistic logic
Authors: Ramanujam R , Sundararajan Vaishnavi , Suresh S P 
Published: January 2020

AbstractWe study procedures for the derivability problem of fragments of intuitionistic logic. Intuitionistic logic is known to be PSPACE-complete, with implication being one of the main contributors to this complexity. In fact, with just implication alone, we still have a PSPACE-complete logic. We study fragments of intuitionistic logic with restricted implication and develop algorithms for these fragments which are based on the proof rules. We identify a core fragment whose derivability is solvable in linear time. Adding disjunction elimination to this core gives a logic which is solvable in co-NP. These sub-procedures are applicable to a wide variety of logics with rules of a similar flavour. We also show that we cannot do better than co-NP whenever disjunction elimination interacts with other rules.
Secondary-electron radiation accompanying hadronic GeV–TeV gamma-rays from supernova remnants
Authors: Huang Yan , Li Zhuo , Wang Wei , Zhao Xiaohong 
Published: January 2020

ABSTRACT
The synchrotron radiation from secondary electrons and positrons (SEPs) generated by hadronic interactions in the shock of supernova remnant (SNR) could be a distinct evidence of cosmic ray (CR) production in SNR shocks. Here, we provide a method where the observed gamma-ray flux from SNRs, created by pion decays, is directly used to derive the SEP distribution and hence the synchrotron spectrum. We apply the method to three gamma-ray bright SNRs. In the young SNR RX J1713.7−3946, if the observed GeV−TeV gamma-rays are of hadronic origin and the magnetic field in the SNR shock is B ≳ 0.5 mG, the SEPs may produce a spectral bump at 10−5–10−2 eV, exceeding the predicted synchrotron component of the leptonic model, and a soft spectral tail at ≳100 keV, distinct from the hard spectral slope in the leptonic model. In the middle-aged SNRs IC443 and W44, if the observed gamma-rays are of hadronic origin, the SEP synchrotron radiation with B ∼ 400–500 μG can well account for the observed radio flux and spectral slopes, supporting the hadronic origin of gamma-rays. Future microwave to far-infrared and hard X-ray (&gt;100keV) observations are encouraged to constraining the SEP radiation and the gamma-ray origin in SNRs.
A hydrodynamical study of outflows in starburst galaxies with different driving mechanisms
Authors: Yu B P Brian , Owen Ellis R , Wu Kinwah , Ferreras Ignacio 
Published: January 2020

ABSTRACT
Outflows from starburst galaxies can be driven by thermal pressure, radiation, and cosmic rays. We present an analytic phenomenological model that accounts for these contributions simultaneously to investigate their effects on the hydrodynamical properties of outflows. We assess the impact of energy injection, wind opacity, magnetic field strength, and the mass of the host galaxy on flow velocity, temperature, density, and pressure profiles. For an M82-like wind, a thermally dominated driving mechanism is found to deliver the fastest and hottest wind. Radiation-driven winds in typical starburst-galaxy configurations are unable to attain the higher flow velocities and temperatures associated with thermal and cosmic ray-driven systems, leading to higher wind densities which would be more susceptible to cooling and fragmentation at lower altitudes. High opacity winds are more sensitive to radiative driving, but terminal flow velocities are still lower than those achieved by other driving mechanisms at realistic opacities. We demonstrate that variations in the outflow magnetic field can influence its coupling with cosmic rays, where stronger fields enable greater streaming but less driving near the base of the flow, instead with cosmic rays redirecting their driving impact to higher altitudes. The gravitational potential is less important in M82-like wind configurations, and substantial variations in the flow profiles only emerge at high altitude in massive haloes. This model offers a more generalized approach to examine the large-scale hydrodynamical properties for a wide variety of starburst galaxies.