bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-free DNA screening for aneuploidies in 7113 pregnancies: single Italian centre study
Authors: Mesoraca Alvaro , Margiotti Katia , Dello Russo Claudio , Cesta Anthony , Cima Antonella , Longo Salvatore Antonio , Barone Maria Antonietta , Viola Antonella , Sparacino Davide , Giorlandino Claudio 
Published: June 2020

AbstractIntroductionNon-invasive prenatal testing (NIPT) using cell-free foetal DNA has been widely accepted in recent years for detecting common foetal chromosome aneuploidies, such as trisomies 13, 18 and 21, and sex chromosome aneuploidies. In this study, the practical clinical performance of our foetal DNA testing was evaluated for analysing all chromosome aberrations among 7113 pregnancies in Italy.MethodsThis study was a retrospective analysis of collected NIPT data from the Ion S5 next-generation sequencing platform obtained from Altamedica Medical Centre in Rome, Italy.ResultsIn this study, NIPT showed 100% sensitivity and 99.9% specificity for trisomies 13, 18 and 21. Out of the 7113 samples analysed, 74 cases (1%) were positive by NIPT testing; foetal karyotyping and follow-up results validated 2 trisomy 13 cases, 5 trisomy 18 cases, 58 trisomy 21 cases and 10 sex chromosome aneuploidy cases. There were no false-negative results.ConclusionIn our hands, NIPT had high sensitivity and specificity for common chromosomal aneuploidies such as trisomies 13, 18 and 21.
Does Financial Market Structure Affect the Cost of Raising Capital?
Authors: Brugler James , Comerton-Forde Carole , Hendershott Terrence 
Published: June 2020

AbstractWe provide evidence on market structure and the cost of raising capital by examining changes in market structure in U.S. equity markets. Only the Order Handling Rules (OHR) of the Nasdaq, the one reform that reduced institutional trading costs, lowered the cost of raising capital. Using a difference-in-differences framework relative to the New York Stock Exchange (NYSE) that exploits the OHR’s staggered implementation, we find that the OHR reduced the underpricing of seasoned equity offerings by 1–2 percentage points compared with a pre-OHR average of 3.6%. The effect is the largest in stocks with the largest reduction in institutional trading costs after the OHR.
Language Shift and Identity Reproduction among Diaspora Sindhis in India and Southeast Asia
Authors: COOK MATTHEW A. , DAVID MAYA KHEMLANI 
Published: June 2020

AbstractThis article examines the relationship between language shift and identity among diaspora Sindhis in India and Southeast Asia. It focuses on questions concerning how members of this community reproduce identity through language shift. The first part of the article describes identity and language shift among diaspora Sindhis in post-partition India. It argues that language shift facilitates the reproduction of core cultural modalities among diaspora Sindhis. The second part describes the history of diaspora Sindhis in Southeast Asia and analyses language shift. It contends that language shift enables diaspora Sindhis to suspend a connection between mother-tongue proficiency and identity. The article concludes by discussing how the diaspora Sindhi experience retunes the interval that conventionally connects language shift to cultural change.
Caught between Two Nationalisms: The Iran League of Bombay and the political anxieties of an Indian minority
Authors: PATEL DINYAR 
Published: June 2020

AbstractIn 1922, a group of wealthy Parsis in Bombay founded an organization that they dubbed the Iran League. Originally designed to assist their fellow Zoroastrians in Iran, who had suffered from centuries of oppression, the League quickly expanded its objectives to include the promotion of broader Indo-Iranian cultural and economic relations. It became a major player in the flow of ideas, literature, business, and tourist traffic between the two countries. Parsi fervour for Iran stemmed from the brand of Iranian nationalism promoted by Reza Shah, which celebrated the country's Zoroastrian past. In response, the League's leaders argued that the Parsis of India could play a special role in the ‘regeneration’ of Iran under the shah's supposedly benign rule. By the 1930s, however, Parsis’ embrace of Iranian nationalism became a clear reflection of their deep concerns about Indian nationalist politics: they cast Iran as an idealized alternative to contemporary India, where the Indian National Congress had supposedly taken an ominously ‘anti-Parsi’ turn. The Iran League, therefore, was caught between two nationalisms. Worry about India's future even prompted some Parsis to argue that their community should ‘return’ to their ancestral homeland of Iran. The story of the Iran League thus demonstrates the complex position of minorities vis-à-vis the brands of nationalism in development during the interwar years. The Parsis, a wealthy but microscopic minority, responded to political anxieties at home by romanticizing a foreign country and taking part in a wholly foreign nationalist project.
ProspectiveSalmonellaEnteritidis surveillance and outbreak detection using whole genome sequencing, Minnesota 2015–2017
Authors: Rounds J. M. , Taylor A. J. , Eikmeier D. , Nichols M. M. , Lappi V. , Wirth S. E. , Boxrud D. J. , Smith K. E. , Medus C. 
Published: June 2020

AbstractClusters ofSalmonellaEnteritidis cases were identified by the Minnesota Department of Health using both pulsed-field gel electrophoresis (PFGE) and whole genome sequencing (WGS) single nucleotide polymorphism analysis from 1 January 2015 through 31 December 2017. The median turnaround time for obtaining WGS results was 11 days longer than for PFGE (12vs.1 day). WGS analysis more than doubled the number of clusters compared to PFGE analysis, but reduced the total number of cases included in clusters by 34%. The median cluster size was two cases for WGS compared to four for PFGE, and the median duration of WGS clusters was 27 days shorter than PFGE clusters. While the percentage of PFGE clusters with a confirmed source (46%) was higher than WGS clusters (32%), a higher percentage of cases in clusters that were confirmed as outbreaks reported the vehicle or exposure of interest for WGS (78%) than PFGE (46%). WGS cluster size was a significant predictor of an outbreak source being confirmed. WGS data have enhancedS. Enteritidis cluster investigations in Minnesota by improving the specificity of cluster case definitions and has become an integral part of theS. Enteritidis surveillance process.
Not just another large atrial septal defect: complex anatomy, challenging procedure, and an unusual complication
Authors: Haddad Raymond N. , Abdel Massih Tony , Saliba Zakhia 
Published: June 2020

AbstractWe report the case of a 59-year-old patient with a complex atrial septal defect in whom a 40-mm Amplatzer™ septal occluder was surgically extracted 50 days following implantation. Deployment manoeuvres were challenging leading to an immediate pericardial effusion that was closely monitored and uneventfully drained after 11 days. A dry pericardium was documented until 4 weeks of outpatient routine follow-up. However, the device was surgically explanted 2 weeks later, when an urgent chest computed tomography performed for worrisome symptoms showed pericardial effusion recurrence with peripheral contrast enhancement. Surprisingly, the surgical view showed a well-positioned device and an intact pericardium. We discuss the atypical sequence of clinical findings misleading our clinical judgement and precipitating surgery.
New onset severe right ventricular failure associated with COVID-19 in a young infant without previous heart disease
Authors: Rodriguez-Gonzalez Moises , Rodríguez-Campoy Patricia , Sánchez-Códez Maria , Gutiérrez-Rosa Irene , Castellano-Martinez Ana , Rodríguez-Benítez Amado 
Published: June 2020

AbstractWe present our recent experience with a 6-month-old infant with a personal history of short bowel syndrome that presented with fever, cyanosis, and cardiogenic shock secondary to severe pulmonary hypertension and right ventricular failure without pulmonary thromboembolism. He did not present signs of toxin-mediated disease or Kawasaki disease. He was finally diagnosed with SARS-CoV-2 infection. If this presentation is confirmed in future research, the severe cardiovascular impairment in children with COVID-19 could be also attributable to the primary pulmonary infection, not only to a multisystem inflammatory syndrome but also in children without heart disease.
Dizygotic Twin Infants: Controversial Case Study Series/Twin Research Reviews: Twin and Non-twin ICSI Conceptions; Emory University Twin Study; Labor in Multiple Pregnancy After Previous C-Section Delivery; Cell-Free DNA Fetal Fraction in Twin Pregnancies/News Reports: Twin Survivor of Auschwitz; Twins Trading Places; Identical Twin Foals; Twins Born in Different Decades; Twins Ambulette Service
Authors: Segal Nancy L. 
Published: June 2020

AbstractThis article describes a 1930s case study series involving dizygotic female twin infants. The twins’ development was evaluated following periods of intentionally restricted practice and minimal social stimulation. In the opinion of the author of the current article, the study is very unsettling and unacceptable, despite the lack of institutional review boards at that time. This discussion is followed by twin research reviews of recent papers concerning twin and non-twin intracytoplasmic sperm injection conceptions, the Emory University Twin Study of cardiac and brain functions, labor trials in multiple pregnancies after previous C-section delivery and cell-free DNA fetal fraction in twin pregnancies. The article concludes with news items of a twin survivor of Auschwitz, a situation in which twins traded places, the rare birth of identical twin foals, the novel delivery of co-twins in different decades and the Twins Ambulette Service.
Developing a Coral Proxy System Model to Compare Coral and Climate Model Estimates of Changes in Paleo‐ENSO Variability
Authors: Lawman A. E. , Partin J. W. , Dee S. G. , Casadio C. A. , Di Nezio P. , Quinn T. M. 
Published: June 2020

AbstractCoral records of surface‐ocean conditions extend our knowledge of interannual El Niño–Southern Oscillation (ENSO) variability into the preinstrumental period. That said, the wide range of natural variability within the climate system as well as multiple sources of uncertainties inherent to the coral archive produce challenges for the paleoclimate community to detect forced changes in ENSO using coral geochemical records. We present a new coral proxy system model (PSM) of intermediate complexity, geared toward the evaluation of changes in interannual variance. Our coral PSM adds additional layers of complexity to previously published transfer functions of sensor models that describe how the archive responds to sea surface temperature (SST) and salinity. We use SST and salinity output from the Community Earth System Model Last Millennium Ensemble 850 control to model coral oxygen isotopic ratios and SST derived from Sr/Ca. We present a detailed analysis of our PSM using climate model output for sites in the central and southwest Pacific before extending the analyses to span the broader tropical Pacific. We demonstrate how variable growth rates, analytical and calibration errors, and age model assumptions systematically impact estimates of interannual variance and show that the relative magnitude of the change in interannual variance is location dependent. Importantly, however, we find that even with the added uncertainties in our PSM, corals from many circum‐Pacific locations are broadly able to capture decadal and longer (decadal+) changes in ENSO variability. Our code is publicly available on GitHub to facilitate future comparisons between model output and coral proxy data.
Variability of the Sub‐Antarctic Mode Water Subduction Rate During the Argo Period
Authors: Qu Tangdong , Gao Shan , Fine Rana A. 
Published: June 2020

AbstractBoth a quasi‐biennial variability and an overall linearly increasing trend are identified in the Sub‐Antarctic Mode Water (SAMW) subduction rate across the Southern Hemisphere ocean, using the Argo data during 2005–2019. The quasi‐biennial variability is mainly due to variability of the mixed layer depth. Variability of wind stress curl in the SAMW formation regions associated with the Southern Annular Mode plays a critical role in generating the quasi‐biennial variability of the mixed layer depth and consequently the SAMW subduction rates. The SAMW subduction rate across the Southern Hemisphere ocean, long‐term mean totaling 56 Sv, has increased at 0.73 ± 0.65 Sv year−1 over the past 15 years. The increase has directly contributed to the observed increase in the total SAMW volume. Much of this increasing trend can be explained by the deepening mixed layers, which in turn are primarily forced by the strengthening westerly winds under an increasing Southern Annular Mode.
Relative Importance of Greenhouse Gases, Sulfate, Organic Carbon, and Black Carbon Aerosol for South Asian Monsoon Rainfall Changes
Authors: Westervelt Daniel M. , You Yujia , Li Xiaoqiong , Ting Mingfang , Lee Dong Eun , Ming Yi 
Published: June 2020

AbstractThe contribution of individual aerosol species and greenhouse gases to precipitation changes during the South Asian summer monsoon is uncertain. Mechanisms driving responses to anthropogenic forcings need further characterization. We use an atmosphere‐only climate model to simulate the fast response of the summer monsoon to different anthropogenic aerosol types and to anthropogenic greenhouse gases. Without normalization, sulfate is the largest driver of precipitation change between 1850 and 2000, followed by black carbon and greenhouse gases. Normalized by radiative forcing, the most effective driver is black carbon. The precipitation and moisture budget responses to combinations of aerosol species perturbed together scale as a linear superposition of their individual responses. We use both a circulation‐based and moisture budget‐based argument to identify mechanisms of aerosol and greenhouse gas induced changes to precipitation and find that in all cases the dynamic contribution is the dominant driver to precipitation change in the monsoon region.
Vortex 4.0 on chip
Authors: Zhang Qing , Ni Jincheng , Qiu Cheng-Wei 
Published: June 2020

Abstract
The orbital angular momentum (OAM) of light has promising applications, ranging from information multiplexing and high-speed optical communication to computation. Dynamically tunable and switchable vortex microlasers combined with direct photocurrent detection of the topological charges of OAM states have paved unexplored routes for the development and integration of fourth-generation (4.0) vortex technology, potentially on chip.
Estimating mortality among inpatients with acute exacerbation of chronic obstructive pulmonary disease using registry data
Authors: Pei Zhengcun , Sun Yixin , Wang Shengfeng , Chen Yahong , Yang Ting , Huang Kewu , Zhang Yan , Huang Yin , Wang Chen , Zhan Siyan 
Published: June 2020

AbstractThe study aimed to investigate the demographic characteristics, clinical features, diagnoses, and treatments of hospitalized exacerbation COPD patients, as well as their disease prognoses and economic costs. The study planned to enroll 7600 hospitalized patients (aged ≥18 years with main diagnosis as AECOPD). Study patients were recruited since September 2017, followed up with a 3-year observing period. In the baseline visit, information on demographic characteristics, clinical features, diagnoses, and treatments were collected. In the following visits, treatments and examinations, recurrence of AECOPD, re-admission to hospital, complications, and mortality were recorded. Several validated questionnaires were applied at specific visits. This study included data from 1 September 2017 until 31 December 2022. The data would be used to estimate all-cause mortality during hospital stay, AECOPD recurrence within 1 month after discharge, all-cause and cause-specific mortality, frequency of AECOPD recurrence, lung function, life quality, healthcare costs in the study period, etc.
Three-dimensional real time imaging of amyloid β aggregation on living cells
Authors: Kuragano Masahiro , Yamashita Ryota , Chikai Yusaku , Kitamura Ryota , Tokuraku Kiyotaka 
Published: June 2020

AbstractAlzheimer’s disease (AD) is a progressive disorder of the brain that gradually decreases thinking, memory, and language abilities. The aggregation process of amyloid β (Aβ) is a key step in the expression of its neurocytotoxicity and development of AD because Aβ aggregation and accumulation around neuronal cells induces cell death. However, the molecular mechanism underlying the neurocytotoxicity and cell death by Aβ aggregation has not been clearly elucidated. In this study, we successfully visualized real-time process of Aβ42 aggregation around living cells by applying our established QD imaging method. 3D observations using confocal laser microscopy revealed that Aβ42 preferentially started to aggregate at the region where membrane protrusions frequently formed. Furthermore, we found that inhibition of actin polymerization using cytochalasin D reduced aggregation of Aβ42 on the cell surface. These results indicate that actin polymerization-dependent cell motility is responsible for the promotion of Aβ42 aggregation at the cell periphery. 3D observation also revealed that the aggregates around the cell remained in that location even if cell death occurred, implying that amyloid plaques found in the AD brain grew from the debris of dead cells that accumulated Aβ42 aggregates.
Effect of information on geographical origin, duration of transport and welfare condition on consumer’s acceptance of lamb meat
Authors: Caroprese Mariangela , Ciliberti Maria Giovanna , Marino Rosaria , Napolitano Fabio , Braghieri Ada , Sevi Agostino , Albenzio Marzia 
Published: June 2020

AbstractAnimal production system and welfare conditions can influence consumers’ acceptance, as meat from animals grazing in natural pasture and labelled with information about high standards of welfare is preferred. In addition, geographical origin of food is recently considered one of the main information influencing the consumers’ acceptance. Local products are collectively associated with high quality attributes by the consumers related to shorter transport and good welfare. Lamb meat is considered local and typical food; however, it is common to find in the same market both local and imported lamb meat. The present investigation aimed at understanding the importance of information about geographical origin, transport duration, and welfare condition of lambs for consumers and their actual liking. Moreover, the quality of lamb meat from local and imported animals as affected by short or long transport was assessed. Data demonstrated that both short and long transport did not affect organoleptic quality of meat; this result was corroborated by an absence of both metabolic and immune stressors in long term transport lambs except for haptoglobin, cortisol and glucose. However, the expected and actual acceptability were affected by the information with higher scores for local lamb when information on the geographical origin, transport duration, and welfare condition was provided to the consumers.
A century of high elevation ecosystem change in the Canadian Rocky Mountains
Authors: Trant Andrew , Higgs Eric , Starzomski Brian M. 
Published: June 2020

AbstractMountain ecosystems serve as sentinels of change, and those in the Canadian Rocky Mountains have undergone a pronounced shift over the past century. We present quantitative analyses of 81 high-resolution image pairs of systematic historic surveys and repeat photographs of Canadian Rocky Mountain habitats, measuring treeline advance, changes in tree density, and shifts in growth form from krummholz to trees. With a time-lapse of 68 to 125 years (mean 93.5 years) between image pairs, these photographs contain novel information about long-term ecological change across broad spatial scales. In the 197 linear km of mountain habitat over 5 degrees of latitude examined, we found evidence of treeline advance at 90/104 sites, increases in tree density at 93/104 sites, and many sites (79/95) showing detectable changes in the growth form of trees from krummholz to erect tree form. Using generalized linear mixed models, we found that treeline at higher altitudes and further north had a greater probability of advancing while regional climate factors in our model did not significantly explain our results. Historic references, such as those documented here, are invaluable for providing conservation targets and for contextualizing disturbance and broad scale ecosystem change.
Parameters of the Earth’s Free Core Nutation from Diurnal Strain Tides
Authors: Amoruso Antonella , Crescentini Luca 
Published: June 2020

AbstractEarth deformation at the diurnal tidal frequencies includes the resonant tidal-forcing response caused by the Free Core Nutation (FCN), a retrograde mode related to the slight misalignment of the rotation axes of the outer core and mantle. We analyse data from four underground high-sensitivity laser extensometers, whose signal-to-noise ratio in the diurnal tidal band is particularly high, and provide an alternative independent estimate of the FCN complex frequency with respect to more usual techniques (nutation and gravity). Firstly, we differentiate displacements due to diurnal solid tides to obtain extension along any azimuthal direction in terms of three complex parameters (A, S, C) which depend on latitude and frequency. Then, we demonstrate that we can invert the FCN complex frequency and the sensitivity of Im(A) and Re(S) to the resonance from our data. Lastly we obtain the probability distributions of those four parameters. Our results are in full agreement with those from nutation and gravity, as well as with reference IERS (International Earth Rotation and Reference Systems Service) values. Sensitivities of Im(A) and Re(S) to the resonance are estimated here for the first time and are in agreement with values computed using reference Love and Shida numbers from IERS.
Refractive index gas sensor based on the Tamm state in a one-dimensional photonic crystal: Theoretical optimisation
Authors: Zaky Zaky A. , Ahmed Ashour M. , Shalaby Ahmed S. , Aly Arafa H. 
Published: June 2020

AbstractGas sensors are important in many fields such as environmental monitoring, agricultural production, public safety, and medical diagnostics. Herein, Tamm plasmon resonance in a photonic bandgap is used to develop an optical gas sensor with high performance. The structure of the proposed sensor comprises a gas cavity sandwiched between a one-dimensional porous silicon photonic crystal and an Ag layer deposited on a prism. The optimised structure of the proposed sensor achieves ultra-high sensitivity (S = 1.9×105 nm/RIU) and a low detection limit (DL = 1.4×10−7 RIU) compared to the existing gas sensor. The brilliant sensing performance and simple design of the proposed structure make our device highly suitable for use as a sensor in a variety of biomedical and industrial applications.