bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kompos dan PGPR (Plant Growth Promoting Rhizobacteria) Pada Lahan Kering Terhadap Produksi Sawi (Brassica rapa L.)
Authors: Kurniasih Farida Puput , Soedrajat Raden 
Published: June 2020

The increasing of demand for agricultural product and the narrowing of fields where fields are currently being prioritized for cultivating food crops forcing them to take and use dry land. Problem happened by conducting agricultural activities on dry land such as limited water availability, low microorganism population and low nutrient avaibility. Water avaibility on dry land can be optimized by providing compost and PGPR. The productivity of Sawi nauli varieties according to the minister of agriculture decision (2009) that 37-39 tons/ha with a population per hectare are 93.000 plants. This purpose of this study is to determine the effect of compost and PGPR on dry land about pakchoy productivity. This study also used factorial completely randomized design and replicated 3 times. The design of two treatments are: The first: compost which consists of 4 levels with a dose of 5 kilograms of soil, 4900 grams of soil with 100 grams of compost, 4800 grams of soil with 200 grams of compost, 4700 grams of soil with 300 grams of compost. For the second factor is PGPR which consists of 4 levels with a dose of 0 milligrams/plant, 100 milligrams/plant, 200 milligram/plant and 300 milligram/plant. The data obtained were analyzed by using analysis of variance (ANOVA). Then, the results obtained from the ANOVA test were followed by the Standart Error Mean (SEM). Based on the results of the study it is known that there are influences from each single factor and combination of treatments. Compost treatment showed significantly different results on variable number of leaves, number of leaf chlorophyll and dry weight of plants. Whereas there is a very significant effect on plant height and plant fresh weight. On a single factor PGPR showed no significant results on variable plant height, number of leaf chlorophyll, but showed a significant effect on variable number of leaves, plant fresh weight and plant dry weight. The combination of compost and PGPR treatment showed no significant results on variable plant height, number of leaves, number of leaf chlorophyll, and plant dry weight. The treatment combination treatment showed a significant effect on the fresh weight variable of the plant
DETERMINANTS OF REAL EXCHANGE RATE: A BEHAVIOURAL AND FUNDAMENTAL DYNAMIC ANALYSIS IN LATIN AMERICAN COUNTRIES
Authors: Chavez Cesar 
Published: June 2020

In this research, we analyze the determinants of the real exchange rate through the fundamentals and behavioral factors, adding other variables as monetary aggregates, economic growth, domestic savings, and productivity. We worked with thirteen Latin American countries from 1980 to 2018 and we used three estimates such as fixed-effects, random-effects, and System GMM. The findings show that although the real exchange rate has a large random component, due to the high coefficient presented by the past values of that variable, there are other variables such as terms of trade, net foreign assets, tax revenue, monetary aggregates, savings rates and productivity, or real interest rate differentials, relative price and economic growth, which can impact negatively and positively respectively. Keywords: Real Exchange Rate, System GMM, Macroeconomics FactorsJEL Classification: E52, E62, C33, C53
CERVICAL PENETRATING INJURY IN ZONE 2
Authors: Silva Luis Fernando Barbosa , Silva Viviane de Deus , Ferreira Larissa Mendonça , Oliveira Joao Guilherme Silva , Junior Reginaldo Maia 
Published: June 2020

SUMMARY: Several vital structures, of both the aerodigestive and vascular systems, are contained in the cervical regions. Cervical lesions have high complexity and high morbidity and mortality. They are more common in young men inserted in a context of violence. The objective of this study was to demonstrate an injury by firearm with transfixation of the trachea, approached by cervicotomy in which was performed a termino-terminal anastomosis of the affected segment. The patient presented satisfactory clinical and surgical outcomes.
REINCIDÊNCIA DA DOENÇA DE CHAGAS NO BRASIL POR VIAS ALTERNATIVAS DE TRANSMISSÃO
Authors: ARAUJO LARISSA , FIGUEIRA CAROLINE BARROS , VILELA SANTOS PAULO CESAR , SOARES MICHEL MARTINS , MARTINS KAROL-LAYNE MACENA , TAKADA JOÃO PAULO ZELLMER , SOUZA LETICIA BATISTA , FIGUEIREDO BARBOSA GUSTAVO ANTONIO 
Published: June 2020

Este estudo tem como objetivo, identificar a incidência de casos notificados da doença de Chagas, assim como, elucidar a via de transmissão mais frequente no Brasil, destacar os fatores que corroboram com esta reincidência da doença e evidenciar se há necessidade de maiores investimentos em vigilância epidemiológica para a doença de Chagas no Brasil. Trata-se de um estudo epidemiológico, transversal e retrospectivo, onde foi realizada uma busca sistemática na literatura disponível em bancos de dados de relevância científica no meio médico, LILACS e SCieLO, onde buscou-se por publicações que tratassem da incidência atual da doença de Chagas no Brasil. Entre os estudos analisados, foi detectado um aumento significativo de notificações da doença de Chagas, com ênfase nos casos da doença em fases agudas. Observou-se ainda que a via oral foi a de maior prevalência entre as formas de transmissão. Uma vez que a maior parcela das políticas públicas se encontra voltadas para o controle da transmissão vetorial e transfusional da doença de Chagas, nota-se uma menor atenção ao controle de alimentos contaminados, uma vez que a transmissão por via oral foi a mais apontada em todos os estudos analisados. Destarte, urge a necessidade de desenvolvimento de políticas que visem o controle sanitário de alimentos, principalmente os extraídos de áreas consideradas endêmicas e que são comercializados e consumidos in natura.
Palavras-chave: Doença de Chagas; Transmissão; Monitoramento Epidemiológico.
Cervical Kyphosis in Spinal Muscular Atrophy
Authors: Bernatz James T. , Anderson Paul A. , Halanski Matthew A. 
Published: June 2020

Case:
A 12-year-old boy with spinal muscular atrophy (SMA) Type II presented 5 years after undergoing spinal growing rod placement with cervical kyphosis at C2-3. He underwent anterior cervical discectomy and fusion but 6 years later developed significant kyphosis at the adjacent C3-4 level.

Conclusion:
We describe a rare adjacent segment kyphotic condition in a young man with SMA Type II. Clinicians should be cognizant of the risk of cervical kyphosis in adolescent patients with SMA.
Catastrophic Polyethylene Failure and Fractured Femoral Component in Modern Knee Arthroplasty Design
Authors: Matar Hosam E. , Cameron Hugh U. , Gollish Jeffrey D. 
Published: June 2020

Case:
We report a 67-year-old gentleman who presented with a painful unstable knee. He had undergone a successful total knee arthroplasty 12 years earlier and was highly functional. He presented with a 10-month history of mild pain, instability, and gait alteration. During revision surgery, there was a loss of bony support, and a fractured femoral component was identified. He required constrained revision components for reconstruction and made an uneventful recovery.

Conclusions:
Fractured femoral components are rare complications of modern primary total knee arthroplasty. Loss of bony support in critical areas of high loading will inevitably lead to catastrophic component failure.
Fat Embolism Syndrome: The Ambiguity of Diagnosis in the Postarthroplasty Patient
Authors: Rosser Kenrick , Wilton Sophia , Farrington William J. 
Published: June 2020

Case:
We present the case of an otherwise healthy, 74-year-old woman, who underwent bilateral hip arthroplasty and subsequently presented with decreased level of consciousness, mimicking a severe postoperative delirium. After several days and investigations, the diagnosis of fat embolism syndrome (FES) was reached, and appropriate management was given.

Conclusion:
Orthopedic surgeons and their teams should consider FES as a differential diagnosis of prolonged post-operative delirium. With supportive management these patients can make a full recovery without lasting neurological symptoms. Our patient has shown no subsequent sequelae after 10-month follow-up.
Preferensi Masyarakat Terhadap Rumah Sakit Syariah (Studi Kasus Terhadap Masyarakat Surabaya)
Authors: Latifah Luluk 
Published: June 2020

Pada saat label syariah semakin menjamur, baik pada dunia perbankan maupun non perbankan, banyak produk-produk barang atau jasa halal yang ditawarkan oleh pelaku usaha, dan masyarakat sangat antusias untuk mengikutinya. Dari produk halal yang ditawarkan oleh para pelaku usaha yang baru-baru ini diluncurkan adalah di bidang pelayanan kesehatan yang secara legal juga sudah difatwakan oleh DSN MUI (Dewan Syariah Nasional Majelis Ulama Indonesia) No.107/DSN-MUI/X/2016 tentang Pedoman Penyelenggara Rumah Sakit Syariah, yang dimotori oleh MUKISI (Majelis Upaya Kesehatan Islam Seluruh Indonesia). Selama ini pembicaraan mengenai Rumah Sakit Syariah masih pada tatanan manajemen saja, pada penelitian ini ingin mengetahuinya dari aspek masyarakatnya, terutama pada faktor preferensinya. Penelitian ini dilaksanakan di Kota Surabaya dengan menggunakan tehnik pengambilan sampel secara simple random sampling dan besar sampel dengan aplikasi simple size 2.0 berjumlah 217 sampel pada masyarakat Kota Surabaya. Untuk pengolahan datanya menggunakan chi-square test. Hasilnya, pada variabel usia dan jenis kelamin tidak signifikan mempengaruhi tingkat preferensi masyarakat terhadap keberadaan rumah sakit syariah. Sikap, pendidikan dan pengetahuan mempunyai hubungan yang signifikan terhadap tingkat preferensi masyarakat terhadap keberadaan rumah sakit syariah. Untuk variabel sikap: hasilnya masyarakat sangat mendukung sekali dengan keberadaan rumah sakit syariah. Variabel pendidikan, hasilnya semakin tinggi pendidikan masyarakat semakin tinggi pula tingkat preferensinya tentang keberadaan rumah sakit syariah. Variabel Pengetahuan, hasilnya semakin baik tingkat pengetahuan masyarakat maka semakin tinggi tingkat preferensinya terhadap keberadaan rumah sakit syariah.
The Correlation Analysis between the Oxford Classification of Chinese IgA Nephropathy Children and Renal Outcome -A retrospective cohort study
Authors: Wu Heyan , Xia Zhengkun , Gao Chunlin , Zhang Pei , Yang Xiao , Wang Ren , Wang Meiqiu , Peng Yingchao 
Published: June 2020

Abstract
Background: The 2016 Oxford Classification's MEST-C scoring system predicts outcomes in adults with IgA nephropathy (IgAN), but it lacks large cohort validation in children with IgAN in China. We sought to verify whether the Oxford classification could be used to predict the renal outcome of children with IgAN. Methods : A total of 1243 Chinese children with IgAN who underwent renal biopsy in Jinling Hospital were enrolled from January 1, 2000, to December 31, 2017, in this retrospective cohort study. The primary endpoint of the study was a composite of either ≥50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD). We probed into the relationship between the Oxford classification and renal outcome. Results : There were 29% of children with mesangial proliferation(M1), 35% with endocapillary proliferation (E1), 37% with segmental sclerosis/adhesion lesion (S1), 23% with moderate tubular atrophy/interstitial fibrosis (T1 25–50% of cortical area involved), 4.3% with severe tubular atrophy/interstitial fibrosis (T2 >50% of cortical area involved), 44% with crescent in< 25% of glomeruli(C1), and 4.6% with crescent in>25% of glomeruli (C2).During a median follow-up duration of 7.2 (4.6–11.7) years, 171 children (14%) developed ESRD or 50% decline in eGFR. In the multivariate COX regression model, only segmental sclerosis/adhesion (HR2.7,95%CI 1.8～4.2, P ＜0.001) and tubular atrophy/interstitial fibrosis (HR6.6,95%CI 3.9～11.3, P ＜0.001) were confirmed to be independent risk factors of poor renal outcome in the whole cohort, whereas crescent showed significant association with prognosis only in children received no immunosuppressive treatment.Conclusions: This study revealed that segmental sclerosis/adhesion and tubular atrophy/interstitial fibrosis were independently associated with poor renal outcome in Chinese children with IgA nephropathy.
Endoscopic intraventricular hematoma evacuation surgery versus external ventricular drainage for the treatment of patients with moderate to severe intraventricular hemorrhage: a multicenter, randomized, controlled trial
Authors: Zhu Junhao , Tang Chao , Cong Zixiang , Yang Jin , Cai Xiangming , Liu Yuxiu , Ma Chiyuan 
Published: June 2020

Abstract
Background: The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are small and all of them are retrospective studies. The aim of this study is to explore the prognosis of patients with moderate to severe IVH who undergo endoscopic IVH evacuation surgery versus those who undergo EVD alone.Methods: The study is a prospective, randomized, controlled, multi-center clinical trial. Nine hundred and fifty-six subjects with moderate to severe IVH across four tertiary hospitals in China will be randomly assigned (1:1) to receive either endoscopic IVH evacuation surgery or EVD. The primary objective is to compare patients’ survival rate at 12 months after surgery.Discussion: The trial is designed to investigate the prognostic benefits of endoscopic IVH evacuation surgery for patients with moderate to severe IVH. Currently, it has never been investigated in a prospective randomized controlled clinical trial.Trial registration: ClinicalTrials.gov, NCT04037267. Registered on 26 July 2019.
Assessing the role of two populations of Aedes japonicus japonicus for Zika virus transmission under a constant and a fluctuating temperature regime.
Authors: Glavinic Uros , Varga Jasmin , Paslaru Anca Iona , Hauri Jeannine , Torgerson Paul , Schaffner Francis , Veronesi Eva 
Published: June 2020

Abstract
Background Since the huge epidemic of Zika virus (ZIKV) in Brazil in 2015, questions were raised to understand which mosquito species could transmit the virus. Aedes aegypti has been described as the main vector. However, other Aedes species (e.g. Ae. albopictus and Ae. japonicus) proven to be competent for other Flaviviruses (e.g.West Nile, dengue and yellow fever), have been described as potential vector for ZIKV under laboratory conditions. To name one, the Asian bush mosquito Ae. japonicus which is widely distributed with high abundances in Central-Western Europe. In the present study, infection, dissemination and transmission rates of ZIKV (Dak84 strain) in two populations of Ae. japonicus from Switzerland (Zürich) and France (Steinbach, Haut-Rhin) were investigated under constant (27 °C) and fluctuating (14-27 °C, mean 23 °C) temperature regimes.Results The two populations were each able to transmit ZIKV under both temperature regimes. Infectious virus particles were detected in the saliva of females from both populations, regardless of the incubation temperature regime, from 7 days post exposure to infectious rabbit blood. The highest amount of Plaque Forming Unit (PFU) (400/ml) were recorded 14 days post oral infection in the Swiss population incubated at constant temperature. No difference in term of infection, dissemination and transmission rate were found between mosquito populations.Temperature had no effect on infection rate but the fluctuating temperature regime resulted in higher dissemination rates comparing to constant temperature, regardless of the population. Finally, transmission efficiency ranged between 7-23% and 7-10% for the constant temperature and 0-10% and 3-27% under fluctuating temperatures for the Swiss and the French populations, respectively.Conclusions This is the first work confirming vector competence for ZIKV of Ae. japonicus originating from Switzerland and France at realistic summer temperatures under laboratory conditions. Considering the continuous spread of this species in the northern part of Europe and its adaptation at cooler temperatures, preventative control measures should be adopted to prevent possible ZIKV epidemics.
Detection of gray matter microstructural changes in Alzheimer’s disease continuum using fiber orientation
Authors: Lee Peter , Kim Hang-Rai , Jeong Yong 
Published: June 2020

Abstract
Background: This study aims to investigate feasible gray matter microstructural biomarker with higher sensitivity for early Alzheimer’s disease (AD) detection. We propose diffusion tensor imaging (DTI) measure, ‘radiality’, for early AD biomarker. It is a dot product between cortical surface normal vector and primary diffusion direction, which reflects the fiber orientation within the cortical column. Methods: We gathered neuroimages from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database: 78 cognitive normal, 50 early mild cognitive impairment (EMCI), 34 late mild cognitive impairment (LMCI), and 39 AD patients. Then, we evaluated cortical thickness (CTh), mean diffusivity (MD), amount of amyloid and tau accumulations using positron emission tomography (PET), which are conventional AD magnetic resonance (MR) imaging biomarkers. Radiality was projected on gray matter surface to compare and validate the changes along stages with other neuroimage biomarkers. Results: Results showed decreased radiality primarily in entorhinal, insula, frontal and temporal cortex as disease progresses onward. Especially, radiality could delineate the difference between cognitive normal and EMCI group while other biomarkers could not. We looked into the relationship between the radiality and other biomarkers to validate its pathological evidence in AD. Overall, radiality showed high association with conventional biomarkers. Additional ROI analysis exhibits dynamics of AD related changes as stages onward. Conclusion: Radiality in cortical gray matter showed AD specific changes and relevance with other conventional AD biomarkers with higher sensitivity. Besides, it could show group differences in early AD changes from EMCI which show advantage for early diagnosis than using conventional biomarkers. We provide the evidence of structure changes with cognitive impairment and suggest radiality as a sensitive biomarker for early AD.
Serum A Proliferation-Inducing Ligand and MicroRNA-223 are Associated with Rheumatoid Arthritis: Diagnostic and Prognostic Implications
Authors: Taha Mohamed , Shaker Olfat Gamil , Taha Enas , Taha Noha 
Published: June 2020

Abstract
Background: Current blood-based tests for rheumatoid arthritis (RA) have inherent limitations, necessitating the need for additional new biomarkers for its diagnosis and monitoring disease activity and responsiveness to therapy. microRNAs (miRNAs) and a proliferation-inducing ligand (APRIL) are deregulated in RA and were linked to its pathogenesis. This study investigated serum levels of APRIL, miR-223 and miR-155 in RA patients, their potential as diagnostic and prognostic biomarkers, and their correlation with disease activity and clinicopathological data.Methods: 120 Egyptian patients with RA and 130 healthy controls were included. Serum miRNAs and APRIL were assayed by RT-qPCR and ELISA, respectively. Results: Serum APRIL and miR-223 were significantly upregulated, while miR-155 was unchanged in RA patients compared to controls. Serum miR-223 discriminated RA patients from controls with AUC=0.85, whereas serum APRIL superiorly distinguished the two groups with AUC=1 (sensitivity and specificity= 100% at cutoff>4.19 ng/ml) by receiver-operating-characteristic analysis. Serum miR-223 was a significant predictor for RA diagnosis in multivariate logistic regression analysis. In RA group, serum APRIL was positively correlated with disease activity score (DAS28-CRP). Serum miR-223 expression was positively correlated with serum miR-155, APRIL levels and with the presence of subcutaneous nodules. Serum miR-155 levels were correlated with antinuclear antibody titer in reverse direction.Conclusion: our results suggest serum APRIL and miR-223 could serve as potential biomarkers of RA, with miR-223 as a predictor of RA risk and APRIL as an excellent biomarker of disease activity. Our data could be implicated for accurate and blood-based non-invasive diagnosis and prognosis of RA.
Dietary L-citrulline supplementation modulates nitric oxide synthesis and anti-oxidant status of laying hens during summer season
Authors: UYANGA VICTORIA ANTHONY , Jiao Hongchao , Zhao Jingpeng , Wang Xiaojuan , Lin Hai 
Published: June 2020

Abstract
Background: L-citrulline (L-Cit), a non-protein amino acid, has been implicated in several physiological functions including anti-inflammatory, anti-oxidative, and hypothermic roles, however, there is a paucity of information with regards to its potential in poultry production. This study was designed to investigate the effects of dietary L-Cit supplementation on the production performance, nitric oxide production, and antioxidant status of laying hens during summer period. Hy-Line Brown laying hens (n=288, 34 weeks old) were allotted to four treatment, 6 replicates of 12 chickens each. Dietary treatments of control (basal diets), 0.25%, 0.50 % and 1.00 % L-Cit supplementation were fed to chickens for eight (8) weeks. Production performance, free amino acid profiles, nitric oxide production, and antioxidant properties were measured. Blood samples were collected at the 4th and 8th weeks of the experiment. Results: Air temperature monitoring indicated an average daily minimum and maximum temperatures of 25.02 oC and 31.01 oC respectively. Dietary supplementation with L-Cit did not influence (P > 0.05) the production performance, and rectal temperature of laying hens. Egg shape index was increased (P < 0.05) with increasing levels of L-Cit. Serum-free content of arginine, citrulline, ornithine, tryptophan, histidine, GABA, and cystathionine were elevated, but taurine declined with L-Cit diets. Plasma nitric oxide (NOx) concentration was highest at 1% L-Cit. Likewise, nitric oxide synthase (NOS) activity for total NOS (tNOS) and inducible NOS (iNOS) were upregulated with increasing L-Cit levels, although, tNOS was not affected at the 4th week. Anti-oxidant enzymes including catalase and superoxide dismutase (SOD) were increased with L-Cit supplementation, however, SOD activity was unchanged at 4th week, while total anti-oxidant capacity increased at the 8th week. L-Cit supplementation attenuated the extent of lipid peroxidation, and also inhibited glutathione peroxidase activity. Conclusion: Dietary L-Cit supplementation modulated systemic arginine metabolism, nitric oxide synthesis, antioxidant defense system, and increased the egg shape index of laying hens during the summer season. 1% L-Cit supplementation proved most effective in potentiating these effects and may be adopted for feed formulation strategies.