bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of an Online Mindful Living With Challenge (MLWC) Intervention on Mental Health and Quality of Life Among COVID-19 Patients in China: A Protocol of a Randomized Controlled Trial
Authors: Si Mingyu , Xiao Weijun , Pan Chen , Wang Hao , Huang Yiman , Lian Jun , Mak Winnie WS , Leng Zhiwei , Tang Qiuping , Su Xiaoyou , Jiang Yu , Feng Luzhao , Yang Weizhong , Wang Chen 
Published: December 2020

Abstract
Background COVID-19 can lead to increased psychological symptoms such as post-traumatic stress disorder (PTSD), depression, and anxiety, especially for patients with COVID-19. Studies suggest that mindfulness-based intervention is an effective, easily delivered and non-aggressive online therapy for patients with mental disorders. This study aims to explore the efficacy and possible mechanism of a Mindful Living With Challenge (MLWC) intervention designed for Chinese COVID-19 survivors in alleviating their psychological problems caused by both the disease and the pandemic.Methods This study is a protocol for a randomized controlled trial. More than 1600 eligible participants will be assigned 1:1 to an online MLWC intervention group or a waitlist control group. All participants will be asked to complete online questionnaires at baseline , post-program, and 3-month follow-up. The primary outcome is mental health status which includes PTSD and other psychological symptoms (i.e. depression, anxiety). The secondary outcomes are related physical symptoms including fatigue and sleeplessness assessed by verified scales such as the Fatigue Scale-14, Pittsburgh Sleep Quality Index. In addition, Five Facets Mindfulness Questionnaire, the Nonattachment Scale, the Stillness Scale, the Resilience Style Questionnaire and the Social Support Scale will be used to assess the mindfulness, stillness, nonattachment level, resilience and perceived social support before and after the intervention, which may be the possible mediators and moderators of the link between the MLWC intervention and target outcomes. Data will be analyzed based on an intention-to-treat approach, and SPSS software will be used to perform statistical analysis.Discussion This study will provide scientific evidence on the efficacy and possible mechanism of the MLWC intervention in improving the quality of life and psychological status among COVID-19 survivors in China. Findings from this study will contribute to a growing research field that assesses the effectiveness of mobile-based and theoretically guided interventions for improving the psychological status of the COVID-19 survivors. Moreover, findings from this study will also contribute to the prevention and management of the psychological complications patients face during such public health emergencies.Trial registration Chinese Clinical Trial Registry (ChiCTR), ChiCTR2000037524; Registered on August 29, 2020, http://www.chictr.org.cn/showproj.aspx?proj=60034.
Stercoral Colitis in a Patient with&nbsp;Pediatric Onset&nbsp;Systemic Lupus Erythematosus: Case Analysis and Review of Literature
Authors: Gau Chunchun , Lin Li-lun , Wu Chao-Yi , Huang Jing-Long 
Published: December 2020

Abstract
Background: Systemic lupus erythematosus (SLE) is an autoantibody-related disease that affects multiple organs. Stercoral colitis (SC) is a rare type of inflammatory colitis with a high mortality rate in the elderly. We aimed to report the first case of pediatric-onset lupus in a patient complicated by stercoral colitis and to conduct a literature review of patients with SC under 30 years old to persuade a helpful clues for a rapid diagnosis in young ages.Case presentation: A 28-year-old female presented with a history of lupus, was admitted for severe abdominal pain with unremarkable laboratory data and image and was found to have stercoral colitis during the surgery. Two years later, the patient underwent Hartman’s operation due to ischemia colon. In addition, 10 patients younger than 30 years old (ranged 2 year old to 28 year old) including 7 females and 3 males with a diagnosis of SC were analyzed with clinical presentation, physical examination, laboratory exam, image and treatment. All 10 cases had a favorable outcome without mortality.Conclusions: Stercoral colitis is a rare but lethal complication and should highlight the importance of a multidisciplinary approach. The differential diagnosis should include stercoral colitis in patients with SLE developing unexplained sharp abdominal pain.
Deletion of an enhancer in FGF5 is associated with ectopic expression in goat hair follicles and the cashmere growth phenotype
Authors: Li Yefang , Song Shen , Liu Xuexue , Zhang Yanli , Wang Dandan , He Xiaohong , Zhao Qianjun , Pu Yabin , Guan Weijun , E Guangxin , Ma Yuehui , Jiang Lin 
Published: December 2020

Abstract
Background

Research on cashmere growth has a significant effect on the production of cashmere and a profound influence on cashmere goat breeding. Whole-genome sequencing is a powerful platform to rapidly gain novel insights into the identification of genetic mechanisms underlying cashmere fiber growth.
Results

In this study, we generated whole-genome sequences of 115 domestic goats from China, Nepal and Pakistan, including 51 cashmere goats and 64 non-cashmere goats. We found genetically distinct clusters according to their geographic locations but genetic admixture or introgression may have occurred between the Chinese and Nepalese goats. We identified that the fibroblast growth factor 5 gene (FGF5) shows a strong signature for positive selection in the cashmere goat. The 505-bp indel variant at the FGF5 gene locus appeared to be strongly associated with cashmere growth. Functional validation showed that the insertion variant may serve as an enhancer for transcription factor binding, resulting in increased transcription of the upstream FGF5 gene in non-cashmere goats.
Conclusions

Our study provides useful information for the sustainable utilization and improved conservation of goat genetic resources and demonstrates that the indel mutation in the FGF5 gene could potentially serve as a molecular marker of cashmere growth in cashmere goat breeding.
Mass SARS-CoV-2 serological screening for the Principality of Andorra
Authors: Royo-Cebrecos Cristina , Vilanova David , López Joel , Arroyo Vanessa , Francisco Guillem , Pons Marc , Carrasco Mireia G. , Piqué Josep M. , Sanz Sergi , Dobaño Carlota , García-Basteiro Alberto 
Published: December 2020

Abstract
Andorra is a small country located in the Pyrenees attracting millions of visitors, mainly for ski tourism. We estimated SARS-CoV-2 seroprevalence in the entire country by universal serological testing. From 4–28 May, 2020 two cross sectional serological surveys were conducted using a rapid serological test (nCOV IgG/IgM). 72,964 inhabitants (96.1% of the population) participated. Overall seroprevalence was 11.0%. The odds of being seropositive was higher among seasonal workers (OR 1.87; 95% CI 1.57–2.23), students (OR 1.64; 95% CI 1.48–1.82) or in the population living in La Massana region (OR 2.65; 95% CI 2.43–2.89). A higher seroprevalence was observed in those familiar nuclei with greater numbers of cohabitants: 18% in families with 6 household members or more; 13% in medium size families (3/4/5 people) and 12% in small size (1 to 2 people) nuclei (p < 0.001). Seasonal workers, students and inhabitants based in ski-related areas presented a higher seroprevalence. Mass antibody screening allows to identify infection hotspots and should contribute to the design of tailored interventions to prevent SARS-CoV-2 transmission.
WITHDRAWN: Plant growth promoting Bipolaris sp. CSL-1 mitigate salinity stress in soybean via altering endogenous phytohormonal level, antioxidants and genes expression
Authors: Lubna Lubna , Khan Muhammad Aaqil , Asaf Sajjad , Jan Rehmatullah , Waqas Muhammad , Kim Kyung-Min , Lee In-Jung 
Published: December 2020

Abstract
Background
Salinity stress is one of the most devastating environmental stress that inhibits plants growth and development. Many strategies including plant growth promoting fungi have been reported to mitigate salt stress.
Results
In this study, we adopted environmental friendly technique and screened different plant growth promoting fungi for different PGP traits and salinity stress. Among these isolate CSL1 were selected based on the basis of plant growth promoting characteristics producing IAA, GAs, organic acid and tolerance to NaCl stress. Furthermore, inoculation of fungal isolate CSL1 significantly increased shoot length (16%), root length (37%), shoot fresh and dry weight (19% and 25%), root fresh and dry weight (47 and 51%) and chlorophyll content (24%) under NaCl stress (200 mM). Endogenous ABA level (0.77 folds) were significantly decreased while SA contents (16%) were increase in CSL1 inoculated plants under NaCl stress. Similarly, higher level of antioxidants such as MDA (2 folds), SOA (29%), POD (8 folds) and PPO (3 folds) was observed in NaCl treated non-inoculated plants. ICP analysis showed an increase in Na+ (11 folds) and decrease in K+ content (15%). Furthermore, CSL-1 inoculation improved soybean adaptability against NaCl stress and a significant decrease in GmFDL19 expression (5 folds) GmNARK (4 folds) and GmSIN1 (3 folds) was observed. However, higher expression of GmAKT2 (15%) were observed in CSL-1 treated plants.
Conclusion
Fungal isolate CSL-1 have capability to mitigate salinity stress in soybean, increase plant growth and could be used as valuable ecofriendly microorganism resource, low cost based biotechnological approach for sustainable agriculture in salt affected areas.
Comparing the Performance of the New Fully Automated Urine Particle Analyzer UF-5000 with UF-1000i and Gram Stain in Predicting Bacteria Growth Patterns in Women with Uncomplicated Urinary Tract Infections
Authors: Yang Stephen Shei-Dei , yang Chun-Chun , Chen Yi-Shen , chang Shangjen 
Published: December 2020

Abstract
BackgroudTo compare the performance of the new flow cytometer UF-5000 with UF-1000i (Sysmex, Kobe, Japan) and Gram stain in predicting the bacterial patterns in urine samples MethodsWomen with symptoms suggestive of urinary tract infection were enrolled. Mid-stream urine sample was collected for gram staining, urine analysis and urine culture. Bacterial patterns were classified though UF1000i (none, cocci bacteria or rods/mixed growth), UF-5000 (none, cocci, rods or mixed growth) and Gram stain. Results Among the 102 samples, there were 10 gram-positive cocci, 2 gram-positive bacilli, 66 gram-negative rods, and 24 mixed growth. The sensitivity/specificity of the UF-1000i was 81.8/91.1% for gram-negative rods and 23.5/96.9% for cocci/mixed. The sensitivity/specificity of the UF-5000 was 80.0/88.2% for gram negative rods and 70.0/86.5% for gram-positive cocci.ConclusionsThe UF-5000 demonstrated the good sensitivity and specificity for Gram-negative bacilli bacteria and demonstrated an improved sensitivity for detecting Gram-positive cocci.
Association of Pigmentation Related-Genes Polymorphisms and Geographic Environmental Variables in the Chinese population
Authors: Wang Yuxin 
Published: December 2020

Abstract
Background: Human skin color is highly heritable and one of the most variable phenotypic traits. However, the genetic causes and environmental selective pressures underlying this phenotypic variation have remained largely unknown. To investigate whether the pigmentation related-genes polymorphisms are associated with the geographic environmental variables. We selected randomly 795 healthy individuals from eight ethnic groups in nine provinces in China. Six single nucleotide polymorphisms (SNPs) of SLC45A2 and TYR were genotyped using Agena MassARRAY. The chi-square test and Spearman correlation analysis were used to compare the frequency distribution of genotypes among different ethnic groups and evaluate the relationship between SNP genetic diversity and environmental variables, respectively. Results: The results indicated that rs28777 and rs183671 (SLC45A2) and rs1042602 (TYR) genotype frequency distributions were significantly different between the Xinjiang-Uighur and other ethnic groups (P < 0.05). Spearman correlation analysis found that rs28777 (r = -0.090, P = 0.011), rs183671 (r = -0.105, P = 0.003), rs1042602 (r = -0.108, P = 0.002), rs1126809 (r = -0.151, P < 0.001) allele frequencies were negatively correlated with the longitude; rs183671 (r = 0.151), rs1042602 (r = 0.157) and rs1126809 (r = 0.138) allele frequencies were positively associated with the latitude (P < 0.001); rs183671 (r = 0.116, P = 0.001), rs1042602 (r = 0.105, P = 0.003) and rs1126809 (r = 0.070, P = 0.048) allele frequencies were positively correlated with the sunshine hours; rs183671 (r = -0.076, P = 0.033), rs1042602 (r =-0.079, P = 0.027) and rs1126809 (r = -0.076, P = 0.031) were negatively correlated with the annual average temperature. Conclusions: Our results confirm the idea that environmental factors have been an important selective pressure upon pigmentation related gene polymorphisms.
Silent monster&nbsp;inside the ear! Understanding the level of awareness about Cholesteatoma in hospital visitors of Puducherry.
Authors: Bhat Poornima S , Kaliavaradan Santhanakrishnan , Surendran Pravin , Muruganidhi Nisha 
Published: December 2020

Abstract
Aims: With the COVID-19 pandemic resulting in most centres postponing the non-emergency services, there is a potential risk of under reporting of uncomplicated cholesteatoma cases, due to lack of symptoms and awareness. This study aims to assess the level of knowledge about CSOM, especially cholesteatoma and related harmful practices among general population. Methods: All consenting adult hospital visitors, irrespective of their purpose of visit were invited to participate in this questionnaire based, cross sectional study at the preregistration point of the tertiary care teaching hospital. Data was collected and analyzed using appropriate methods. Results: Among 350 respondents, majority exhibited poor level of knowledge about general perceptions about ear infections [295(84.3%)], perceptions about cholesteatoma[246(70.3%)]; knowledge about intratemporal complications[244(69.7%)]; knowledge about intracranial complications[247(70.6%)] and harmful practices in ear disease patients[279(79.7%)].Multivariate analysis of socio-demographic and ear disease history related characteristics with overall ear disease related knowledge has shown that unskilled workers and unemployed respondents have poor knowledge levels compared to their counterparts, but at the same time the study has found that respondents with higher level of education also exhibited poor levels of knowledge in contrary to the existing evidence. Conclusion: This study highlights the lack of awareness about CSOM, especially cholesteatoma and its complications, harmful practices mainly in rural population, even in well educated groups, and the need for health education measures to create awareness among the general population regarding various areas ofconcern, to prevent a potential increase in the incidence of complications, especially during and post COVID-19 pandemic.
Low Engagement in HIV Services and Progress through the Treatment Cascade among Key Populations Living with HIV in Mozambique: Alarming Gaps in Knowledge of Status
Authors: Boothe Makini , Sathane Isabel , Baltazar Cynthia Semá , Chicuecue Noela , Horth Roberta , Fazito Erika , Raymond Henry Fisher 
Published: December 2020

Abstract
Background. Mozambique has a generalized HIV epidemic of 13.5% among the general population. Early modeling exercises in Mozambique estimate that key populations (KP), defined as men who have sex with men (MSM), female sex workers (FSW), and people who inject drugs (PWID), along with their partners account for about one third of all new infections. There is limited data describing the engagement of KP living with HIV in testing, care and treatment services. Methods. We conducted a secondary data analysis of HIV-positive participants in the first Bio-behavioral Surveillance (BBS) surveys in Mozambique conducted 2011-2014 in order to assess service uptake and progress though the HIV treatment cascade among MSM, FSW, and PWID. Unweighted pooled estimates were calculated for each key population group.Results. Among HIV-positive MSM, 63.2% of participants had ever received an HIV test, 8.8% were aware of their status, 6.1% reported having been linked to care, while 3.5% initiated ART and were currently on treatment. Of the HIV-infected FSW participants, 76.5% reported a previous HIV test and 22.4% were previously aware of their status. Linkage to care was reported by 20.1%, while 12.7% reported having initiated ART and 11.8% reported being on treatment at the time of the survey. Among HIV-infected PWID participants, 79.9% had previously received an HIV test, 63.2% were aware of their HIV status, and 49.0% reported being linked to care for their HIV infection. ART initiation was reported by 42.7% of participants, while 29.4% were on ART at the time of the survey. Conclusion. Among the three high risk populations in Mozambique, losses occurred throughout critical areas of service uptake with the most alarming breakpoint occurring at knowledge of HIV status. Special attention should be given to increasing HIV testing and linkage to ART treatment. Future surveys will provide the opportunity to monitor improvements across the cascade in line with global targets and should include viral load testing to guarantee a more complete picture of the treatment cascade.
Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study
Authors: Engeseth Marit , Enden Tone , Sandset Per Morten , Wik Hilde Skuterud 
Published: December 2020

Abstract
Background Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) of the lower limb, but predictors of PTS are not well established. We aimed to examine predictors of PTS in patients with long-term PTS following proximal DVT. Methods During 2006-09, 209 patients with a first time acute upper femoral or iliofemoral DVT were randomized to receive either additional catheter-directed thrombolysis or conventional therapy alone. In 2017, the 170 still-living participants were invited to participate in a cross-sectional follow-up study. In the absence of a gold standard diagnostic test, PTS was defined in line with clinical practice by four mandatory, predefined clinical criteria: 1. An objectively verified DVT; 2. Chronic complaints (>1 month) in the DVT leg; 3. Complaints appeared after the DVT; and 4. An alternative diagnosis was unlikely. Possible predictors of PTS were identified with multivariate logistic regression. Results 88 patients (52%) were included 8-10 years following the index DVT, and 44 patients (50%) were diagnosed with PTS by the predefined clinical criteria. Younger age and higher baseline Villalta score were found to be independent predictors of PTS, i.e., OR 0.96 (95% CI, 0.93-0.99), and 1.23 (95% CI, 1.02-1.49), respectively. Lack of iliofemoral patency at six months follow-up was significant in the bivariate analysis, but did not prove to be significant after the multivariate adjustments.Conclusions In long-term follow up after high proximal DVT, younger age and higher Villalta score at DVT diagnosis were independent predictors of PTS.
Readmission rate after epilepsy surgery: A systematic review and meta-analysis
Authors: Bameri Omid , Saravani Khadijeh , Salarzaei Morteza 
Published: December 2020

Abstract
Objective Today, quality of care has become a central issue with regard to redesigning health care delivery. For improvement of quality of care, measurement and analysis of outcomes is essential. the aim of this study is to evaluate the 30 day readmission rate of epilepsy surgery.Material and Methods A systematic literature review was performed in April 2020. We reviewed MEDLINE/PubMed, Cochrane Library, and ClinicalTrials.gov for citation or ongoing trials from January 2010 to March 2020. The search criteria were limited to human studies published in English language. The Medical Subject Headings terms used for the search in PubMed were ‘epilepsy surgery’ ,’readmission’, ’reoperation ’ and ‘neurological surgery’. We used random-effects meta-analyses to estimate pooled risk ratios and 95% confidence intervals for early readmissionResults In the 7trials reporting readmission rates, the overall prevalence of readmission and re-operation within 30 days was 10% and 9%. The most common cause of re-admission was seizure(31.6%). The overall mean Elixhauser index among readmitted patients after epilepsy surgery was 8.05.Conclusion Minimizing factors that contribute to readmission in various patient populations and procedures becomes important for patient care, resource utilization, and physician reimbursement.understanding about a readmission rate of 10% can be useful to health systems designing quality improvement efforts.Awareness of the reasons for readmission is important for patient counseling and surgical decision making.In epilepsy surgery, although our study did not show a significant difference but ,readmissions might be reduced with optimization of pre-existing comorbidities
The clinical characteristics and outcome of cryptococcal meningitis with AIDS in a tertiary hospital in China: An observational cohort study
Authors: Wu Liang , Xiao Jiang , Song Yangzi , Gao Guiju , Zhao Hongxin 
Published: December 2020

Abstract
Background Despite the profound impact of antiretroviral therapy in the control of AIDS mortality, central nervous system opportunistic infections remains a significant burden in AIDS patients. This retrospective study aims to elucidate the clinical characteristics, outcome and risk factors of cryptococcal meningitis (CM) poor prognosis in AIDS patients from a tertiary hospital in China.Methods Clinical data from 128 patients admitted in Beijing Ditan Hospital, Capital Medical University from November 2008 to November 2017 was collected. The cohort was stratified based on treatment outcome (effective 79%, and ineffective 21%), and Multivariate Logistic regression analysis used to identify risk factors of poor disease prognosis.Results Age, incidence of cerebral infarction, the proportion of consciousness disorder, and fasting plasma glucose was higher in the ineffective treatment group than the effective treatment group. The duration of treatment in the induction period of the ineffective group was significantly shorter than that of the effective group. Multivariate Logistic regression analysis indicated that the occurrence of cerebral hernia and consciousness disorder were risk factors for the prognosis of AIDS patients with CM infection, while the duration of treatment in the induction period was a indicative of a better prognosis in AIDS with CM infection complications. Finally, shunt decompression therapy correlated with a better disease outcome. Conclusions This retrospective study exposes the main risk factors associated with worse disease prognosis in AIDS patients with CM infection complications.