bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple endocrinological failures as a clinical presentation of a metastatic lung adenocarcinoma
Authors: Ach Taieb , Wojewoda Perrine , Toullet Flora , Ducloux Roxane , Avérous Véronique 
Published: April 2020

Summary
Multiple endocrine metastases are a rare but possible complication of lung adenocarcinoma (LAC). Pituitary metastasis is a rare condition with poor clinical expression. Diabetes insipidus (DI) is its most common presenting symptom. Here we report an original case of a pituitary stalk (PS) metastasis from LAC presenting as central DI followed by adrenal insufficiency (AI) from bilateral adrenal metastasis, without known evidence of the primary malignancy. A 45-year-old woman whose first clinical manifestations were polyuria and polydipsia was admitted. She was completely asymptomatic with no cough, no weight loss or anorexia. Chest radiography was normal. Brain MRI showed a thick pituitary stalk (PS). DI was confirmed by water restriction test and treated with vasopressin with great clinical results. Explorations for systemic and infectious disease were negative. Few months later, an acute AI led to discovering bilateral adrenal mass on abdominal CT. A suspicious 2.3 cm apical lung nodule was found later. Histopathological adrenal biopsy revealed an LAC. The patient received systemic chemotherapy with hormonal replacement for endocrinological failures by both vasopressin and hydrocortisone. We present this rare case of metastatic PS thickness arising from LAC associated with bilateral adrenal metastasis. Screening of patients with DI and stalk thickness for lung and breast cancer must be considered. Multiple endocrine failures as a diagnostic motive of LAC is a rare but possible circumstance.

Learning points:

Adrenal metastasis is a common location in lung adenocarcinoma; however, metastatic involvement of the pituitary stalk remains a rare occurrence, especially as a leading presentation to diagnose lung cancer.

The posterior pituitary and the infundibulum are the preferential sites for metastases, as they receive direct arterial blood supply from hypophyseal arteries.

Patients diagnosed with diabetes insipidus due to pituitary stalk thickness should be considered as a metastasis, after exclusion of the classical systemic and infectious diseases.

The diagnosis of an endocrinological metastatic primary lung adenocarcinoma for patients without respiratory symptoms is often delayed due to a lack of correlation between endocrinological symptoms and lung cancer.

The main originality of our case is the concomitant diagnosis of both endocrinological failures, as it was initiated with a diabetes insipidus and followed by an acute adrenal insufficiency.
Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial
Authors: Fortuin-de Smidt Melony C , Mendham Amy E , Hauksson Jon , Hakim Olah , Stefanovski Darko , Clamp Louise , Phiri Lindokuhle , Swart Jeroen , Goff Louise M , Micklesfield Lisa K , Kahn Steven E , Olsson Tommy , Goedecke Julia H 
Published: April 2020

Objective
We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia and associated changes in regional and ectopic fat.

Research design and methods
Healthy, black South African women with obesity (mean age 23 ± 3.5 years) and of isiXhosa ancestry were randomised into a 12-week aerobic and resistance exercise training group (n = 23) and a no exercise group (control, n = 22). Pre and post-intervention testing included assessment of SI, insulin response to glucose (AIRg), insulin secretion rate (ISR), hepatic insulin extraction (FEL) and disposition index (DI) (AIRg × SI) (frequently sampled i.v. glucose tolerance test); fat mass and regional adiposity (dual-energy X-ray absorptiometry); hepatic, pancreatic and skeletal muscle fat content and abdominal s.c. and visceral adipose tissue volumes (MRI).

Results
Exercise training increased VO2peak (mean ± s.d.: 24.9 ± 2.42 to 27.6 ± 3.39 mL/kg/min, P < 0.001), SI (2.0 (1.2–2.8) to 2.2 (1.5–3.7) (mU/l)−1 min−1, P = 0.005) and DI (median (interquartile range): 6.1 (3.6–7.1) to 6.5 (5.6–9.2) × 103 arbitrary units, P = 0.028), and decreased gynoid fat mass (18.5 ± 1.7 to 18.2 ± 1.6%, P < 0.001) and body weight (84.1 ± 8.7 to 83.3 ± .9.7 kg, P = 0.038). None of these changes were observed in the control group, but body weight increased (P = 0.030). AIRg, ISR and FEL, VAT, SAT and ectopic fat were unaltered after exercise training. The increase in SI and DI were not associated with changes in regional or ectopic fat.

Conclusion
Exercise training increased SI independent from changes in hyperinsulinemia and ectopic fat, suggesting that ectopic fat might not be a principal determinant of insulin resistance in this cohort.
Position of the Siberian Platform and Adjacent Cratonic Terranes in the Paleozoic from Paleontological and Geological Evidence
Authors: Kanygin A.V. , Gonta T.V. , Timokhin A.V. 
Published: April 2020

Abstract
—The comprehensive chorological analyses of benthic and planktonic faunal groups, the reconstruction of paleogeography, and the delineation and correlation of the same-type biofacies and geographic ranges of the fauna suggest that the Paleozoic tectonic blocks of the Verkhoyansk–Chukotka foldbelt (Tas-Khayakhtakh, Selennyakh, Omulevka, Omolon, Okhotsk, and Chukchi inliers) and Kotel’nyi Island originated in the same epicontinental sea basin of the Siberian paleocontinent, being parts of its passive margin located at the place of the recent foldbelt. We provide a rationale for paleontological, sedimentary, and morphometric diagnostic characteristics of rift zones in complex thrust-folded structures. A rift development, with activation phases in the Ordovician and Devonian, is found to have preceded the break-up of the passive margin in the late Paleozoic.
Discovery of Intracratonic Rift in the Upper Yangtze and Its Control Effect on the Formation of the Anyue Giant Gas Field
Authors: Jinhu Du , Zecheng Wang , Caineng Zou , Chunchun Xu , Ping Shen , Baomin Zhang , Hua Jiang , Shipeng Huang 
Published: April 2020

Abstract
—According to drilling and seismic data, the Late Sinian–Early Cambrian intracratonic rift was found in the Deyang–Anyue area of the Upper Yangtze craton. This rift is controlled by a tensional fault and extends in the N–NW direction with a N–S length of 320 km and an E–W width of 50–300 km. After three stages of the rift evolution, i.e., the formation stage, development stage, and dying stage, a favorable near-source accumulation assemblage formed. The research results indicate that: (1) the sedimentation stage of the Late Sinian Dengying Formation is the rift formation stage, during which trough-basin facies sedimentation is developed in the rift, while platform marginal-facies mounds and shoals are developed on both sides, controlling the formation and distribution of high-quality reservoirs in the Dengying Formation; (2) the sedimentation stage of the Early Cambrian Meishucun–Qiongzhusi Formation is the rift development stage, during which deep-water continental-shelf facies argillaceous rocks accumulated in the rift with a thickness of 500–1000 m, indicating the sedimentation of high-quality source rocks; (3) the sedimentation stage of the Canglangpu Formation is the rift dying stage, terminating the evolution history of the intracratonic rift by gap filling. The intracratonic rift is a key factor for the formation of the Anyue giant gas field, where the high-quality source rocks provide abundant gases for the giant gas field. A regional lateral sealing occurred during the rapid rise of the western paleouplift in Central Sichuan during the Late Yanshan–Himalayan period, favorable for the preservation of the Gaoshiti–Moxi giant gas field on the eastern wing of the rift. The intracratonic rift and its role in giant gas accumulation provide a significant reference for deep oil and gas exploration in paleocratonic basins.
STUDI PERTUMBUHAN DAN DEGRADASI FENOL OLEH KULTUR TUNGGAL AKTINOMISETES DARI TANAH GAMBUT
Authors: Masni Tiara Elsita , Linda Tetty Marta , Fibriarti Bernadeta Leni 
Published: April 2020

AbstrakFenol adalah senyawa organik yang bersifat toksik dan larut dalam air, sehingga mudah menimbulkan pencemaran pada perairan dan menurunkan kualitas air. Penelitian ini bertujuan untuk melihat potensi tiga isolat aktinomisetes asal tanah gambut Riau dalam Minimal Salt Medium yang mengandung fenol pada konsentrasi 0 ppm, 200 ppm, 400 ppm, dan 600 ppm serta mengetahui kemampuan aktinomisetes dalam mendegradasi fenol pada konsentrasi 600 ppm menggunakan metode folin ciocalteau. Potensi pertumbuhan isolat L121, L18, L11 menunjukkan total populasi tidak berbeda nyata dengan penambahan 400 ppm dan 600 ppm fenol, tetapi berbeda nyata terhadap 0 ppm dan 200 ppm fenol. Potensi pertumbuhan tertinggi terdapat pada isolat L121 dan terendah pada isolat L11. Kemampuan degradasi fenol oleh masing-masing isolat adalah L121 sebesar 570,80 ppm (95%), L18 sebesar 218,85 ppm (36%) dan L11 sebesar 97,21 ppm (16%) dari konsentrasi fenol awal 600 ppm pada Minimal Salt Medium. Isolat aktinomisetes ini berpotensi dikembangkan untuk penanggulangan pencemaran di lingkungan.Abstract Phenol is an organic compound is toxic and easily soluble in water so easy to cause pollution in a waters such as water quality degradation. The aim of this research is to see the potential of three isolates of actinomycetes from Riau peat soil in Minimal Salt Medium containing phenol concentration 0 ppm, 200 ppm, 400 ppm and 600 ppm and to know the ability of actinomycetes in degradation of phenol at the concentration of 600 ppm using folin ciocalteu. The growth potential of L121, L18, L11 isolates showed the total population was not significantly different with the addition of 400 ppm and 600 ppm of phenol but significantly different from 0 ppm and 200 ppm of phenol. The highest growth potential was found in L121 isolate and lowest in L11 isolate. The degradation ability of phenols by each isolate was L121 570.80 ppm (95%), L18 218.85 ppm (36%) and L11 was able to degrade phenol 97.21 ppm (16%) from the initial phenol concentration of 600 ppm at Minimum Salt Medium.These actinomycetes have the potential to be developed for the overcome of pollution in the environment.
Imag(in)ing the Anthropocene
Authors: Vivanco Luis A. 
Published: April 2020

The popular association of nature films with scientific objectivity and secular environmentalism obscures how these films also deploy mythological, etiological, and cosmogonic symbols, themes, and narratives to create worlds that appeal to audiences. From Disney’s Nature’s Half Acre to March of the Penguins, nature films have employed technical artifice to show nature ‘as it is’, and at the same time operated as a means of storytelling about Creation as a sublime order suffused with meaning and purpose. But in these films, humans largely remained outside the ‘natural’ field of reference. At the threshold of the Anthropocene, in which concerns about human responsibility for degraded planetary conditions are highlighted, new films like Racing Extinction and the Earth—A New Wild series have explored the potential of creating alternative imaginary and visual worlds of nature that include humans, to support the generation of renewed moral purpose for addressing the global ecological crisis.
About “Justitia” (Righteousness) and “Aequitas” (Equity). The contribution of Lactantius († 325) in the specifying of the content of the two constituent elements of the “Jus” – summary
Authors: Dură Nicolae V. 
Published: April 2020

By a brief analysis of the text of Lactantius’s work, entitled „Justitia,” one can say that for Lactantius, „Justitia” (Justice) and „Aequitas” (Equity) were primarily two moral virtues, with theological-philosophical and juridical implications and consequences, hence the moral obligation that any legislator – wherever and whoever he may be – ought to take them into account in the application of Justice.
Podmiot związku wyznaniowego jako zamawiający: wybrane zagadnienia
Authors: Moras Małgorzata , Kroczek Piotr 
Published: April 2020

W Polsce kościoły i inne związki wyznaniowe uczestniczą w obrocie gospodarczym także w sferze zamówień publicznych, działając jako zamawiający. Istnieją sytuacje, w których stosowanie ustawy z dnia 29 stycznia 2004 r. Prawo zamówień publicznych przez te podmioty może być problematyczne. Celem artykułu jest: 1) przedstawienie specyfiki relacji prawnych ze związkami wyznaniowymi w zakresie zamówień publicznych; 2) wskazanie obszarów możliwego zastosowania regulacji własnych związków wyznaniowych w zamówieniach publicznych; 3) przybliżenie na przykładzie podmiotów i prawa Kościoła katolickiego treści tych regulacji. Wnioski płynące z rozważań mogą mieć szczególne znaczenie dla wykonawców ubiegających się o udzielenie zamówienia publicznego.
Paɣiba Salma | Women's Gold
Authors: Doortmont Eza J. 
Published: April 2020

Shea butter is a product traditionally made solely by women. The demand for this product in the world has grown drastically over the past decades and this has changed the production and production space of the commodity significantly.
Women’s Gold is an observational film, telling the story of the shea butter processing women of Tampe-Kukuo, a community on the outskirts of Tamale, the capital of the Northern Region in Ghana. This documentary investigates ideas of social space, dignity and gaining more than material independence, connected to the shea butter industry. The growing demand in the west means bigger productions, exporting the butter and growing profit, but it also means that the sole women-safe space is not guaranteed for the future.
In Vivo Assessment of Size-Selective Glomerular Sieving in Transplanted Human Induced Pluripotent Stem Cell–Derived Kidney Organoids
Authors: van den Berg Cathelijne W. , Koudijs Angela , Ritsma Laila , Rabelink Ton J. 
Published: April 2020

Significance Statement
The ability to differentiate human induced pluripotent stem cells to kidney organoids in vitro holds promise for disease modeling, drug discovery, and clinical application. The authors differentiated such cells to kidney tissue comprising glomerular, proximal, and distal tubular structures. Earlier research demonstrated that these structures become vascularized upon transplantation in mice and show advanced maturation. To investigate whether human induced pluripotent stem cell–derived kidney organoids can also become functional in vivo, they applied high-resolution intravital multiphoton imaging through a titanium imaging window. They demonstrated in vivo glomerular filtration and size-selective glomerular barrier function in the transplanted organoids. This technique can be instrumental for further developing stem cell–derived organoids toward clinical applications.

Background
The utility of kidney organoids in regenerative medicine will rely on the functionality of the glomerular and tubular structures in these tissues. Recent studies have demonstrated the vascularization and subsequent maturation of human pluripotent stem cell–derived kidney organoids after renal subcapsular transplantation. This raises the question of whether the glomeruli also become functional upon transplantation.

Methods
We transplanted kidney organoids under the renal capsule of the left kidney in immunodeficient mice followed by the implantation of a titanium imaging window on top of the kidney organoid. To assess glomerular function in the transplanted human pluripotent stem cell–derived kidney tissue 1, 2, and 3 weeks after transplantation, we applied high-resolution intravital multiphoton imaging through the imaging window during intravenous infusion of fluorescently labeled low and high molecular mass dextran molecules or albumin.

Results
After vascularization, glomerular structures in the organoid displayed dextran and albumin size selectivity across their glomerular filtration barrier. We also observed evidence of proximal tubular dextran reuptake.

Conclusions
Our results demonstrate that human pluripotent stem cell–derived glomeruli can develop an appropriate barrier function and discriminate between molecules of varying size. These characteristics together with tubular presence of low molecular mass dextran provide clear evidence of functional filtration. This approach to visualizing glomerular filtration function will be instrumental for translation of organoid technology for clinical applications as well as for disease modeling.
PENINGKATAN PENGUASAAN KOSAKATA BAHASA ARAB MELALUI PENGGUNAAN MEDIA WORD WALL
Authors: Azizah Hanifah Nur 
Published: April 2020

Application of the word wall method is one of alternative to improve students Arabic vocabulary. A problem for student of class III A in MI Al-Ba’ats is the low of Arabic vocabulary which has an impact on the students learning outcomes. The aim of this skills research are to improve of students Arabic vocabulary skills by using word wall media. This research used the Classroom Action Research (CAR) with fourth cycles. Each cycles concisted of six phases, which: identification of problems, need assessment, idea, implication, and decision making. The subject of the research are 21 students of the class III A MI Al-Ba’ats. The data sources of the research are the research and students. Data collection techniques are used an observation, an interview, tests and documentation. If the individual completeness reaches ≥ 65 and if value of the whole completeness reaches 75% of the students more than ≥ 65, then it could he said as a complete learning outcomes. The average value of learning outcomes in the pre-action is 62 and the value of the whole completeness is 33.3%. The average value of learning outcomes in the first cycle 69 and the value of the whole completeness is 66.7%. The average value of learning outcomes in the second cycle is 73 and the value of the whole completeness is 85.7%. The average value of learning outcomes in the third cycle is 80 and the value of the whole completeness is 95.2%. The average value of learning outcomes in the fourth cycle is 80.1 and the value of the whole completeness is 95.2%. The conclution of this research is by using word wall media, it can improve students Arabic vocabulary skills at class III A of MI Al-Ba’ats.
Activity Level as a Mortality Predictor in a Population Sample after Typical Underwriting Exclusions and Laboratory Scoring
Authors: Rigatti Steven J. , Stout Robert 
Published: April 2020

Objectives.— To quantify the effect of physical activity on the mortality rates of healthy individuals in a population sample, after controlling for other sources of mortality risk.Background.— The widespread availability of activity monitors has spurred life insurance companies to consider incorporating such data into their underwriting practices. Studies have shown that sedentary lifestyles are associated with poor health outcomes and higher risks of death. The aim of this paper is to investigate how well certain measures of activity predict mortality when controlled for other known predictors of mortality including a multivariate laboratory based risk score.Methods.— Data were obtained from the National Health and Nutrition Examination Survey (NHANES) for the years 1999 through 2014. Laboratory and biometric data were scored for mortality risk using a previously developed proprietary algorithm (CRL SmartScore). Data on activity were obtained from the NHANES questionnaires pertaining to activity. In a second analysis, data were obtained from pedometers worn for 1 week by NHANES participants (years 2003-2004, and 2005-2006 only). Before analysis, cases were selected based on commonly used life insurance underwriting criteria to remove from consideration those who have major health issues, which would ordinarily preclude an offer of life insurance.Results.—In fully-adjusted Cox model which included survey-based MET*hours per day as a 3-level categorical variable, the moderate and minimal levels of activity were associated with hazard ratios of 1.15 (95% CI: 1.04-1.28) and 1.38 (95% CI: 1.23-1.56), respectively, when compared to the highest level of activity. When treated as a continuous variable, the fully adjusted model the HR for MET*hours per day was 0.91 (95% CI: 0.87-0.95). In fully adjusted models using pedometer data, the percentage of wear time spent sedentary was associated with mortality (HR: 1.19, 95% CI: 1.09-1.31), while average counts per minute were negatively associated with mortality (HR: 0.82, CI: 0.75-0.90).Conclusions.—It is clear from these results that high proportions of sedentary time are associated with increased mortality, whether the sedentary time is quantified via questionnaire or pedometer. Because both laboratory scores and activity levels remain significant in Cox models where both are included, these factors are largely independent, indicating that they are measuring distinct influences on the risk of mortality.
Evaluating Uncertainties of Phase Velocity Measurements from Cross-Correlations of Ambient Seismic Noise
Authors: Luo Yinhe , Yang Yingjie , Xie Jinyun , Yang Xiaozhou , Ren Fengru , Zhao Kaifeng , Xu Hongrui 
Published: April 2020

Abstract
Ambient-noise tomography (ANT) has become a well-established method to image the crust and uppermost mantle structures in the past 15 yr. Having a good estimate of uncertainties of phase velocity dispersion measurements in ANT is critical as they can guide the level of data fitting in tomography. However, to date, there are still no systemic studies to evaluate these uncertainties. In this study, we obtain cross correlations with different stacking durations from 17 yr of ambient-noise data recorded at 120 stations in the United States. We analyze the variations of signal-to-noise ratio (SNR) and phase velocities of cross correlations. We find that the uncertainties of phase velocities are affected by SNRs, interstation distances, and stacking durations. However, none of those three variables can be solely used as a proxy to estimate the uncertainties of phase velocity measurements. Based on our analysis, we graphically present empirical relations of uncertainties of phase velocity measurements as a function of SNR, interstation distance, and stacking duration. These relations can be employed as a guide to estimate phase velocity uncertainties in applications of ANT, assisting in evaluating the reliability of resulting models from ANT.
Transition and Guiding Strategies of Farmers' Values in Earthquake-stricken Area under the Background of Rural Revitalization
Authors: Zhao Limei 
Published: April 2020

The study of farmers' values has been the focus of experts, scholars, government officials and the media all the time, which has always been in progress. After Wenchuan earthquake, the values of farmers there have changed a lot. It is an urge problem demanding prompt solution and also a very important part of post-disaster reconstruction. The study and analysis of the core socialist values of the farmers in the earthquake-stricken areas can not only develop the theory further, but also provide reference for the future rural revitalization. This paper analyzes the topic from the following three aspects: the main characteristics, the influencing factors and the guiding strategies of the changes of values.
Analysis of Computer Network Security and Preventive Measures in the Data Age
Authors: Li Zhi 
Published: April 2020

<p>With the development of science and technology, the network in human society continues to be improved and enriched, as well as the ability of database technology, which is of super cloud computing ability and extensive data sharing and brings great convenience to the whole country. But at the same time, the data that is used improperly in the network environment not only poses a certain threat to the network system, but also gradually erodes people's lives. For the computer network security problems in the era of big data, this paper first analyzes the location of the problems, and then puts forward the means to solve and prevent the security problems.</p>