bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papillary thyroid carcinoma presenting as metastases at unexpected sites: Report of two cases
Authors: Thomas Renu , Manuel Elezabeth 
Published: September 2020

Papillary thyroid carcinoma (PTC) is the most common form of differentiated thyroid carcinoma (DTC). It is generally confined to the neck with or without spread to regional lymph nodes. Distant metastases is rare, if occurs, it usually involves lung and bone. Additional locations have only been sporadically reported and were identified during the course of follow-up, subsequently to a thyroid surgery. Distant metastases as the initial presentation of PTC is a rare event. We, herein, report two cases of PTC presenting initially as metastases at unusual sites and discuss the importance of meticulous histopathological and immunohistochemical examination in such situations. Our aim is to increase awareness of the unique possibility of PTC presenting as metastatic deposits at unexpected sites.
Formação Docente como ambiente de pensamento: projeto representacional e processos narrativos
Authors: Andrade Daniela Freire , Lisboa Costa Ângela Cristina 
Published: September 2020

O presente trabalho propõe uma análise psicossocial do processo formativo de profissionais da Educação Infantil orientada pela teoria das presentações sociais. São privilegiadas as articulações entre representações sociais e processos narrativos, partindo-se do princípio que a narrativa atua tanto como construção sociocognitiva da realidade, quanto como qualidade paradigmática do espaço. A narrativa contribui para a constituição de um ambiente de pensamento no interior do qual são compartilhados novos conteúdos representacionais que delineiam determinado projeto representacional. Noções como obrigação do tipo contratual, confiança interpessoal e confiança epistêmica são analisadas como fatores que contribuem para o reconhecimento da legitimidade dos processos autorais dos participantes envolvidos e da sua configuração enquanto fórum permanente de aprendizagem e desenvolvimento profissional e pessoal. Apresenta-se análises sobre o caso do projeto de formação Cribiás, Crianças Sabidas e seu pressuposto: Educação Infantil como Espaço Narrativo. Foram realizadas observações e entrevistas com um grupo de 32 profissionais cuja análise de dados gerou núcleos de significações e eixos interpretativos. Os resultados revelam que o processo formativo potencializou o tensionamento do campo representacional e o compartilhamento de novos significados sobre a prática docente na Educação Infantil. O projeto representacional inscrito nas narrativas compartilhadas atuou na iminência de saberes construídos coletivamente.
Theoretical Determination of the Mass Radii of the Nucleons and Heavier Subatomic Particles
Authors: Udema Ikechukwu I. 
Published: September 2020

Background: The literature contains numerous values of nucleon charge radii with greater interest in proton. The mean square negative radii are reported for the neutron, the scientific relevance notwithstanding. Only in very few instances was the mass radius of the nucleon investigated.
Methods: Theoretical and computational methods.
Objectives: The objectives of this research are to derive, based mainly on classical model, the equation of the radii of nucleons and other subatomic particles heavier than the nucleons and determine by calculation based on the equation the radii of such particles, and elucidate why results may be different from literature values.
Results and Discussion: The results showed expectedly that the mass radii of nucleons and heavier subatomic particles are longer than what seemed to be the preferred proton charge radius. The lengths of the calculated radii increase with increase in rest mass of the subatomic particles whose mass must be ³ the mass of any nucleon
Conclusion: The equation of the mass radius of any nucleon and heavier subatomic particles was derived. Expectedly, the radii differ on the basis of differences in masses of the particles. The difference in mass radii as calculated in this research and reported charge radii in the literature may be due to electron capture leading to greater number of elastic collision with resulting neutrons. Two particles of widely different mass possessing different charge must interact attractively or repulsively if they possess similar charges. Otherwise the deflection of beta–rays and similar particles in an electromagnetic field would be impossible.
Comparative Assessment of Awareness and Knowledge of Impact of Energy Use Behaviour among Nigerian Higher Education Institutions Residence Students
Authors: E. A. Olanipekun , C. O. Iyiola 
Published: September 2020

The aim of this study was to understand and compare residence students’ awareness and knowledge of the impacts of their reported energy use practices, and to explore their attitudes and reported behaviour regarding energy saving using data collected from three different higher institutions in Southwest, Nigeria namely Obafemi Awolowo University (OAU), Ile-Ife, Rufus Giwa Polytechnic (RUGIPO), Owo and Adeyemi College of Education, (ACE), Ondo. The findings revealed that there is a significant difference between the three tertiary institutions regarding their level of awareness with RUGIPO having the highest and ACE having the lowest awareness level (F = 3.571, p = 0.002). The research also found that ACE exhibits the highest scores for almost all aspects of energy use behaviour. The correlation analysis shows a significant correlation between level of awareness and energy use behaviour (R =0.897**, p=0.001).The result shows no significant difference between the level of awareness and socio-demographic characteristics of respondents except gender in RUGIPO (F = 7.654, p = 0.007). The result shows no significant difference between the energy use behaviour and socio-demographic characteristics of respondents except age = 23.407, p = 0.000) and academic qualification = 28.232, p = 0.000) for turning off light when not needed.
Heterochrony of postnatal accumulation of nonphosphorylated heavy‐chain neurofilament by neurons of the cat dorsal lateral geniculate nucleus
Authors: Mikhalkin Aleksandr , Nikitina Nina , Merkulyeva Natalia 
Published: September 2020

AbstractAccumulation of the heavy‐chain neurofilaments reflects the maturation status of neuronal structures. The spatial distribution and postnatal developmental dynamic of neurons expressing nonphosphorylated heavy‐chain neurofilaments (labeled by SMI‐32 antibody) were analyzed in the dorsal lateral geniculate nucleus (LGNd) of the cat. Both interlaminar and intralaminar differences in the dynamic of SMI‐32 staining were observed. The following results were obtained: (a) Ascending dorsoventral gradient in the density of SMI‐32 immunopositive (SMI‐32(+)) neurons (the greatest neuronal density in layer Cm, the minor in the top sublayer of layer A). This gradient was most prominent at the earliest stages of postnatal development (1st–2nd weeks) and slowly flattened up to adulthood; (b) Layer A1 exhibits increases in SMI‐32‐positive cells earlier than layer A; (c) The general transient increment in the number and density of SMI‐32(+) neurons around 2–5 postnatal weeks. Since SMI‐32 antibody is considered to be a putative marker for Y cells forming a motion processing stream, we suggest that peculiarities of SMI‐32 staining at geniculate level could reflect the heterogeneity of Y cell subpopulations and the heterochrony of their postnatal maturation.
Enhancement of electron density in the interaction of high‐power electromagnetic waves with inhomogeneous magnetized plasma
Authors: Ghalandari H. , Hashemzadeh M. 
Published: September 2020

AbstractPropagation characteristics of a high‐power electromagnetic wave through an inhomogeneous magnetized plasma is investigated. Considering the momentum transfer equations for electrons and ions and taking into account the ponderomotive force, the distribution of electron density and dielectric permittivity are obtained. Using non‐linear dielectric permittivity and Maxwell's equations in the absence of external current and charge densities, non‐linear wave equations are achieved. The results indicate that the external static magnetic field can modify the profiles of both the electric and magnetic fields. It is also shown that the external static magnetic field enhances the amplitude of the electron density and the non‐linear dielectric permittivity.
Identification of physiologic treatment targets with favourable haemodynamic consequences in heart failure with preserved ejection fraction
Authors: Kaye David M. , Byrne Melissa , Mariani Justin , Nanayakkara Shane , Burkhoff Daniel 
Published: September 2020

AbstractAimsHeart failure with preserved ejection fraction (HFpEF) is characterized by complex pathophysiology including an impaired diastolic reserve. We recently showed that milrinone favourably modifies filling pressures at rest and during exertion in HFpEF patients; however, the responsible mechanism is uncertain. The objective of this study was to develop a clearer understanding of the acutely modifiable physiologic parameters that may be targeted in HFpEF.Methods and resultsWe conducted computer modelling simulations based on invasive haemodynamic assessments, by right heart catheterization, in HFpEF patients at baseline and in response to milrinone. Our aim was to develop a detailed understanding of the physiologic mechanisms, which accounted for the observed actions. The resultant circulatory model of HFpEF encompassed the left ventricular (LV) end‐systolic and end‐diastolic pressure–volume relations, together with stressed blood volume, heart rate, and arterial mechanics. To support the modelled action of milrinone, we conducted complementary LV conductance catheter and echocardiography studies in sheep to evaluate LV end‐systolic and end‐diastolic pressure–volume relations. In HFpEF patients, the acute haemodynamic effects of intravenous milrinone (n = 10) administration compared with placebo (n = 10) included significant reductions in right atrial pressure (7 ± 1 to 3 ± 1 mmHg, P < 0.001) and pulmonary capillary wedge pressure (13 ± 1 to 8 ± 1 mmHg, P < 0.001), while cardiac index increased (2.77 ± 0.19 to 3.15 ± 0.14 L/min/m2, P < 0.05), and mean arterial pressure remained unchanged (95 ± 2 to 93 ± 3 mmHg, P = not significant). Computer simulations showed that these haemodynamic effects were explained by a concomitant 31% reduction in stressed blood volume together with 44% increase in LV end‐systolic elastance (LV Ees). Individually, changes in these parameters were not sufficient to explain the haemodynamic effects of milrinone. In vivo studies conducted in sheep (n = 5) showed that milrinone reduced LV filling pressure (8.0 ± 0.8 to 2.7 ± 0.6 mmHg, P < 0.01) and increased LV Ees (0.96 ± 0.07 to 2.07 ± 0.49, P < 0.05), while no significant effect on LV stiffness was observed (0.038 ± 0.003 to 0.034 ± 0.008, P = not significant).ConclusionsThese data demonstrate that stressed blood volume in HFpEF represents a relevant physiologic target in HFpEF; however, concomitant modulation of other cardiovascular parameters including LV contractility may be required to achieve desirable haemodynamic effects.
Potential survival benefit for patients receiving autologous hematopoietic stem cell transplantation after checkpoint inhibitors for relapsed/refractory Hodgkin lymphoma: A real‐life experience
Authors: Casadei Beatrice , Argnani Lisa , Morigi Alice , Lolli Ginevra , Broccoli Alessandro , Pellegrini Cinzia , Nanni Laura , Stefoni Vittorio , Coppola Paolo Elia , Carella Matteo , Cavo Michele , Zinzani Pier Luigi 
Published: September 2020

AbstractIn recent years, novel drugs are available for the patients with relapsed/refractory Hodgkin lymphoma (HL), like immune checkpoint inhibitors (CPi). These drugs have been able to rescue a cohort of patients who subsequently could receive an allogeneic stem‐cell transplant (SCT). No data were reported for subsequent autologous SCT (ASCT) after CPi. Here, we report our real‐life experience in heavily pretreated HL patients undergoing ASCT as consolidation approach after CPi treatment. A retrospective observational study was conducted. Patients had CPi therapy in the context of clinical trials (n = 6) or in the named patient program (n = 7) between July 2014 and November 2019: 9 out of 13 received pembrolizumab and the remaining four underwent nivolumab. A median of 12 cycles (range, 3–16) of CPi therapy were infused. Thirteen patients underwent ASCT after CPi: 11 (84.6%) patients obtained a complete response (CR) and 2 had progression of disease, with an overall response rate of 84.6%. With a median follow‐up of 3.3 years (range, 1.1–5.5), only one CR patient had disease relapse after 3.9 months from ASCT, leading to an estimated disease‐free survival of 87.5% at 56.9 months. The estimated 5‐year progression‐free survival was 73.4% and overall survival was 92.3% at 4.8 years, respectively. No unexpected or cumulative toxicity was observed. Our results indicated that ASCT may represent a further effective therapeutic option as consolidation in HL after CPi treatment that today represents the last conventionally recognized therapeutic line.
The harder firms practice strategic management, the better they are
Authors: Elbanna Said , Al Katheeri Bakheet , Colak Mustafa 
Published: September 2020

AbstractThe integrated practice of strategic management, that is the use of the three components of the strategic management process (formulation, implementation, and evaluation) does matter. Firms should plan intensively and pay attention to choosing strategic planning tools that best fit their needs. No matter how sound the formulated plans are, firms will not benefit if these plans are neither implemented nor evaluated correctly. The harder firms practice strategic management, the better their performance and competitiveness will be.
Practice patterns for neuroimaging and transfusion therapy for management of neurologic complications in sickle cell anemia: DISPLACE consortium
Authors: Phillips Shannon , Schlenz Alyssa M. , Mueller Martina , Melvin Cathy , Adams Robert J. , Kanter Julie ,   (on behalf of the DISPLACE investigators)
Published: September 2020

AbstractBackgroundChildren with sickle cell anemia (SCA) are at risk for neurologic complications (stroke and silent cerebral infarct). The 2014 National Heart, Lung, and Blood Institute (NHLBI) guidelines for sickle cell disease include recommendations for initiation and maintenance of chronic red cell transfusion (CRCT) therapy for children with SCA at risk for or with ischemic stroke. The guidelines do not include well‐delineated recommendations for cerebral imaging for stroke screening. The purpose of this study was to evaluate current stroke risk screening, prevention, and intervention practices amongst the Dissemination and Implementation of Stroke Prevention Looking at the Care Environment (DISPLACE) study sites.ProcedureA survey was administered to DISPLACE site principal investigators to identify current stroke prevention practices relative to the Stroke Prevention Trial in Sickle Cell Anemia (STOP) study protocols and the 2014 NHLBI guidelines. Data were analyzed using descriptive statistics and line‐by‐line analysis of comments.ResultsSites consistently applied NHLBI recommendations to initiate CRCT for ischemic stroke and abnormal transcranial Doppler ultrasound (TCD) results. Similarly, nearly all sites reported obtaining an magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA) following an abnormal TCD result. There was wide variation for other indications for MRI/MRA, frequency of MRI/MRA, and other neurological indications for initiating CRCT.ConclusionsGuideline‐based practices for preventing ischemic stroke through TCD and CRCT initiation were evident in nearly all sites. Wide variation in practices pertaining to MRI/MRA exists, potentially influenced by more recent stroke prevention trials. New guidelines from the American Society of Hematology were published in April 2020, which may reduce practice variation.
Reproductive male partner testing when the female is identified to be a genetic disease carrier
Authors: Simone Laurie , Khan Shama , Ciarlariello Molly , Lin Julia , Trackman Sarah , Heiman Gary A. , Ashkinadze Elena 
Published: September 2020

AbstractObjectiveTo quantify carrier testing uptake rates for male partners of women found to be a carrier(s) for autosomal recessive conditions and to understand reasons for declining testing (uptake rate).MethodsA retrospective chart review of 513 female patients seen at Rutgers‐Robert Wood Johnson Medical School found to be carriers through expanded carrier screening (ECS) panels. The aims of this study were to determine how often their male partner chose testing, reasons for declining and the type of methodology chosen for their screening.ResultsMale partner uptake rate was 77%. We identified that the most significant barrier to male partner testing is female patients not following up on their own carrier screening results, thus missing the opportunity for partner testing. When male partners were provided options for testing, the most reported reason for declining is the belief it would have no impact on pregnancy management (20%). A carrier couple rate of 8.3% was identified of partners tested.ConclusionDespite a relatively high male testing uptake rate, a quarter of carrier females did not proceed with testing their partner. To ascertain fetal risk, results for both parents is necessary. Pretest counseling should stress need for potential male partner follow‐up testing.
Exact D7-brane embedding in the Pilch-Warner background
Authors: Chen-Lin Xinyi , Dekel Amit 
Published: September 2020

AbstractA new supersymmetric D7-brane embedding in the Pilch-Warner gravitational background is found exactly, by solving the supersymmetric condition. In the dual holographic picture, our setting corresponds to adding a quenched fundamental matter sector to$$ \mathcal{N} $$N= 2∗super Yang-Mills theory, at zero temperature. We show that previous results in the same setting are missing the Wess-Zumino term in the D-brane action, and how our results complete the picture.
An Evaluation of Parent Training Interventions in Scotland: The Psychology of Parenting Project (PoPP)
Authors: Saunders Rob , Brack Marita , Renz Brenda , Thomson Judy , Pilling Stephen 
Published: September 2020

AbstractEarly-onset behavioural difficulties persisting into the pre-school years, can make young children vulnerable to poor long-term outcomes including the development of conduct disorders, which are linked to significantly higher societal costs. Several parenting interventions have been shown to reduce behavioural difficulties in children and this evaluation presents outcomes from the Psychology of Parenting Project (PoPP), a national implementation programme delivered in early years services in Scotland. This evaluation of service implementation reports on a large cohort of children (2204, age: 2–5 years) whose parents/caregivers participated in PoPP group-based parenting interventions. We explored change in parent-reported Strengths and Difficulties Questionnaire (SDQ) scores following either the Incredible Years Pre-school Basic or the Level 4 Group Triple P interventions. Latent profile analysis (LPA) was used to identify statistically distinct sub-groups of children based on SDQ subscale scores (emotional, conduct, hyperactivity, peer problems and prosocial). Pre- and post-intervention SDQ scores were available for 58% of children. Large intervention effects were reported and analyses showed that 60% of “at-risk” children were no longer scoring in the at-risk range post-interventions. LPA identified four statistically-distinct profiles of children. Children from “low” and “moderate” behavioural problem profiles benefited more from Triple P, whereas “severe” and “hyperactivity-focused” problem profiles displayed better outcomes following Incredible Years. When delivered through a robust implementation scheme, these parenting interventions can be effective in routine service settings and produce clinically important improvements. These findings and the identification of distinct profiles of children who may respond differentially to interventions could guide the planning of future dissemination schemes.
Evolution of microstructure and hardness during artificial aging of an ultrafine-grained Al-Zn-Mg-Zr alloy processed by high pressure torsion
Authors: Gubicza Jenő , El-Tahawy Moustafa , Lábár János L. , Bobruk Elena V. , Murashkin Maxim Yu , Valiev Ruslan Z. , Chinh Nguyen Q. 
Published: September 2020

AbstractAn ultrafine-grained (UFG) Al-4.8%Zn-1.2%Mg-0.14%Zr (wt%) alloy was processed by high pressure torsion (HPT) technique and then aged at 120 and 170 °C for 2 h. The changes in the microstructure due to this artificial aging were studied by X-ray diffraction and transmission electron microscopy. It was found that the HPT-processed alloy has a small grain size of about 200 nm and a high dislocation density of about 8 × 1014 m−2. The majority of precipitates after HPT are Guinier–Preston (GP) zones with a size of ~ 2 nm, and only a few large particles were formed at the grain boundaries. Annealing at 120 and 170 °C for 2 h resulted in the formation of stable MgZn2 precipitates from a part of the GP zones. It was found that for the higher temperature the fraction of the MgZn2 phase was larger and the dislocation density in the Al matrix was lower. The changes in the precipitates and the dislocation density due to aging were correlated to the hardness evolution. It was found that the majority of hardness reduction during aging was caused by the annihilation of dislocations and some grain growth at 170 °C. The aging effect on the microstructure and the hardness of the HPT-processed specimen was compared to that observed for the UFG sample processed by equal-channel angular pressing. It was revealed that in the HPT sample less secondary phase particles formed in the grain boundaries, and the higher amount of precipitates in the grain interiors resulted in a higher hardness even after aging.