bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide Identification of Differently Expressed lncRNAs, mRNAs, and circRNAs in Patients with Osteoarthritis
Authors: Sun Yeqing , Chen Lei , Zhang Yingqi , Zhang Jincheng , Tiwari Shashi Ranjan 
Published: July 2020

Background:
Osteoarthritis (OA), one of the most important causes leading to joint
disability, was considered as an untreatable disease. A series of genes were reported to regulate the
pathogenesis of OA, including microRNAs, Long non-coding RNAs and Circular RNA. So far, the
expression profiles and functions of lncRNAs, mRNAs, and circRNAs in OA are not fully
understood.

Objective:
The present study aimed to identify differentially expressed genes in OA.

Methods:
The present study conducted RNA-seq to identify differentially expressed genes in OA.
Ontology (GO) analysis was used to analyze the Molecular Function and Biological Process. KEGG
pathway analysis was used to perform the differentially expressed lncRNAs in biological pathways.

Results:
Hierarchical clustering revealed a total of 943 mRNAs, 518 lncRNAs, and 300 circRNAs,
which were dysregulated in OA compared to normal samples. Furthermore, we constructed
differentially expressed mRNAs mediated protein-protein interaction network, differentially
expressed lncRNAs mediated trans-regulatory networks, and competitive endogenous RNA
(ceRNA) to reveal the interaction among these genes in OA. Bioinformatics analysis revealed that
these dysregulated genes were involved in regulating multiple biological processes, such as wound
healing, negative regulation of ossification, sister chromatid cohesion, positive regulation of
interleukin-1 alpha production, sodium ion transmembrane transport, positive regulation of cell
migration, and negative regulation of inflammatory response. To the best of our knowledge, this
study for the first time, revealed the expression pattern of mRNAs, lncRNAs and circRNAs in OA.

Conclusion:
This study provided novel information to validate these differentially expressed RNAs
may be as possible biomarkers and targets in OA.
Anticancer Active Heterocyclic Chalcones: Recent Developments
Authors: Dandawate Prasad , Ahmed Khursheed , Padhye Subhash , Ahmad Aamir , Biersack Bernhard 
Published: July 2020

Background:
Chalcones are structurally simple compounds that are easily accessible by synthetic
methods. Heterocyclic chalcones have gained the interest of scientists due to their diverse biological activities.
The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications
dealing with this topic warrants an up-to-date compilation.

Methods:
Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as
common web-based literature searching tools. Pertinent and current literature was covered from 2015/2016 to
2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones
are summarized.

Results:
Simply prepared chalcones have emerged over the last years with promising antitumor activities.
Among them, there are a considerable number of tubulin polymerization inhibitors. But there are also new chalcones
targeting special enzymes such as histone deacetylases or with DNA-binding properties.

Conclusion:
This review provides a summary of recent heterocyclic chalcone derivatives with distinct antitumor
activities.
Fixed-Ratio Combinations of Basal Insulin and GLP-1RA in the Management of Type 2 Diabetes Mellitus: Highlights from the Literature
Authors: Lisco Giuseppe , De Tullio Anna , Guastamacchia Edoardo , Triggiani Vincenzo 
Published: July 2020

:
New pieces of evidence suggest that combining basal insulin with glucagone-like peptide 1
receptor agonists (GLP-1RA) in patients with type 2 diabetes could promptly ameliorate glucose control
and prevent both hypoglycemic events and unnecessary weight gain compared to more intensive
insulin regimens.

:
To review the efficacy/effectiveness and safety of fixed-ratio combinations of basal insulin and GLP-
1RA (FRCs).

:
Authors searched PubMed/MEDLINE, ClinicalTrials.gov, Cochrane Library, and Google Scholar for
freely available original articles, randomized clinical trials (RCTs), clinical reviews, and meta-analysis
written in English until January 2020.

:
FRCs provide significative reductions in HbA1c levels in both insulin-naïve (-1.4% to -2%) and insulin-
experienced (-1.5% to -2%) type 2 diabetic patients with moderate glucose impairment. More patients
achieved the recommended glycemic targets on FRCs compared to those on mono-therapy with
basal insulin or GLP-1RAs. The intensification with FRCs results in better glycemic control compared
to basal insulin at fasting as well as during the postprandial state. The frequency of hypoglycemia is
similar or lower in patients treated with FRCs than in those on basal insulin alone at a similar dose.
Weight trend can be variable, ranging from -2.7 to +2 Kg for iDegLira and -0.7 to -1.3 Kg for iGlar-
Lixi. However, a lower weight gain is obtained with iDegLira compared to iDeg (-2.2 to -2.5 Kg),
iGlar (-1.7 to -3.2 Kg), and basal-bolus (-3.6 Kg) as well as with iGlarLixi compared to iGlar
(-1.4 Kg).

:
FRCs should be considered to safely improve the metabolic control in type 2 diabetic patients with
moderate glycemic impairment while on oral medications, basal oral regimen or GLP-1RAs. However,
a few but significative pieces of evidence suggest that FRCs could be a safe and effective treatment
instead of a low dose basal-bolus intensification for patients with mild or moderate glucose impairment
in order to reduce the risk of hypoglycemia and unnecessary weight gain, and for simplifying treatment
regimen as well.
The Association between Apolipoprotein E Polymorphism and Response to Statins in Group of Hyperlipidemic Patients
Authors: Jabr Rasha , Gharaibeh Munir , Zayed Ayman A. , Zihlif Malek 
Published: July 2020

Background and Objectives:
APOE has an important role in lipids metabolism, and in the
variability in low density lipoprotein (LDL) response to statins treatment between individuals. In this
study, we aim to investigate the association between APOE polymorphism and response to statins in
Jordanian hyperlipidemic patients at the diabetic clinic of Jordan University Hospital.

Methods:
One hundred and fifty two Jordanian Hyperlipidemic patients (52 males and 100 females)
aged between 35-75 years were enrolled in this study. This study was approved by the Institutional
Review Board (IRB) of Jordan University Hospital. The genotypes of the patients were identified by
polymerase chain reaction followed by restriction fragment length polymorphism assay method (PCRRFLP).

Results and Conclusions:
The study showed that there is an association between APOE polymorphism
and response to statin therapy. Patients who were APOE ε4 carriers had lower response to statins compared
to ε3 and ε2 carriers (p=0.002). In addition, we found that there was no significant association
between APOE polymorphism and LDL baseline (p=0.214). No significant differences were found in
APOE genotypes distribution between males and females (p=0.06). No significant association was
found between age and APOE genotypes (p=0.347). A genotype screening test for dyslipidemic Jordanian
patients is recommended to choose the appropriate treatment decisions, dosage, and to recognize
the potential side effects of statin therapy.
Blue-Space Restoration Theory extends the Understanding of the Quranic Verses of Water
Authors: Zaino Ammar Ayman , Abbas Mohamed Yusoff 
Published: July 2020

Through all times, scholars interpreted the Quranic verses of water by emphasising on the essential role of water upon the physical formation of plants. This study aimed to extend this interpretation from a behavioural science background. Mix methods were used, systematic literature review and integrative analysis. With the blue-space theory, It concluded that water does not have a role in building the physical-form only. But, also the spiritual-creation. God mentioned in the Quran that water brings everything alive; it seemed that it was not limited to the physical form of a human, as mentioned by scholars. But also the spiritual form.
Keywords: Blue-space; Water; Quran; Quality Of Life.
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i14.2195
Age and Attitudes Towards an Internet-Mediated, Pedometer-Based Physical Activity Intervention for Chronic Obstructive Pulmonary Disease: Secondary Analysis
Authors: Robinson Stephanie A , Wan Emily S , Shimada Stephanie L , Richardson Caroline R , Moy Marilyn L 
Published: July 2020

BackgroundChronic obstructive pulmonary disease (COPD) is prevalent among older adults. Promoting physical activity and increasing exercise capacity are recommended for all individuals with COPD. Pulmonary rehabilitation is the standard of care to improve exercise capacity, although there are barriers that hinder accessibility. Technology has the potential to overcome some of these barriers, but it is unclear how aging adults with a chronic disease like COPD perceive technology-based platforms to support their disease self-management.ObjectiveGuided by the unified theory of acceptance and use of technology, the current retrospective secondary analysis explores if age moderates multiple factors that influence an individual with COPD’s openness toward an internet-mediated, pedometer-based physical activity intervention.MethodsAs part of an efficacy study, participants with COPD (N=59) were randomly assigned to use an internet-mediated, pedometer-based physical activity intervention for 12 weeks. At completion, they were asked about their experience with the intervention using a survey, including their performance expectancy and effort expectancy, facilitating conditions (ie, internet use frequency and ability), and use of the intervention technology. Logistic regression and general linear modeling examined the associations between age and these factors.ResultsParticipants ranged in age from 49 to 89 years (mean 68.66, SD 8.93). Disease severity was measured by forced expiratory volume in the first second percent predicted (mean 60.01, SD 20.86). Nearly all participants (54/59) believed the intervention was useful. Regarding effort expectancy, increasing age was associated with reporting that it was easy to find the time to engage in the intervention. Regarding facilitating conditions, approximately half of the participants believed the automated step count goals were too high (23/59) and many did not feel comfortable reaching their goals (22/59). The probability of these perceptions increased with age, even after accounting for disease severity. Age was not associated with other facilitating conditions or use of the technology.ConclusionsAge does not influence performance expectancy or use of technology with an internet-mediated, pedometer-based physical activity intervention. Age is associated with certain expectations of effort and facilitating conditions. Consideration of age of the user is needed when personalizing step count goals and time needed to log in to the website.Trial RegistrationClinicalTrials.gov NCT01772082; https://clinicaltrials.gov/ct2/show/NCT01772082
COVIDApp as an Innovative Strategy for the Management and Follow-Up of COVID-19 Cases in Long-Term Care Facilities in Catalonia: Implementation Study
Authors: Echeverría Patricia , Mas Bergas Miquel Angel , Puig Jordi , Isnard Mar , Massot Mireia , Vedia Cristina , Peiró Ricardo , Ordorica Yolanda , Pablo Sara , Ulldemolins María , Iruela Mercé , Balart Dolors , Ruiz José María , Herms Jordi , Clotet Sala Bonaventura , Negredo Eugenia 
Published: July 2020

Background
The coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide public health crisis that requires new management approaches. COVIDApp is a mobile app that was adapted for the management of institutionalized individuals in long-term care facilities.

Objective
The aim of this paper is to report the implementation of this innovative tool for the management of long-term care facility residents as a high-risk population, specifically for early identification and self-isolation of suspected cases, remote monitoring of mild cases, and real-time monitoring of the progression of the infection.

Methods
COVIDApp was implemented in 196 care centers in collaboration with 64 primary care teams. The following parameters of COVID-19 were reported daily: signs/symptoms; diagnosis by reverse transcriptase–polymerase chain reaction; absence of symptoms for ≥14 days; total deaths; and number of health care workers isolated with suspected COVID-19. The number of at-risk centers was also described.

Results
Data were recorded from 10,347 institutionalized individuals and up to 4000 health care workers between April 1 and 30, 2020. A rapid increase in suspected cases was seen until day 6 but decreased during the last two weeks (from 1084 to 282 cases). The number of confirmed cases increased from 419 (day 6) to 1293 (day 22) and remained stable during the last week. Of the 10,347 institutionalized individuals, 5,090 (49,2%) remained asymptomatic for ≥14 days. A total of 854/10,347 deaths (8.3%) were reported; 383 of these deaths (44.8%) were suspected/confirmed cases. The number of isolated health care workers remained high over the 30 days, while the number of suspected cases decreased during the last 2 weeks. The number of high-risk long-term care facilities decreased from 19/196 (9.5%) to 3/196 (1.5%).

Conclusions
COVIDApp can help clinicians rapidly detect and remotely monitor suspected and confirmed cases of COVID-19 among institutionalized individuals, thus limiting the risk of spreading the virus. The platform shows the progression of infection in real time and can aid in designing new monitoring strategies.
O ESTADO DO CONHECIMENTO SOBRE A FORMAÇÃO DE PROFESSORES DE MATEMÁTICA NOS INSTITUTOS FEDERAIS
Authors: Dueli Leandro De Jesus , Portugal Maria Jesus Salinas , Souza Simone Ariomar de 
Published: July 2020

O presente artigo é parte de uma pesquisa doutoral que tem como objeto de estudo o campo da Formação de Professores no Brasil, em particular a formação ofertada pelos Institutos Federais, criados em 2008. O número de cursos de Licenciatura nesse novo lócus aumentou vertiginosamente nos últimos anos se tornando um ambiente profícuo para investigação, dadas suas peculiares características históricas, políticas e sociais. As pesquisas desenvolvidas a respeito dos cursos de formação de professores de Matemática neste lócus já nos apontam os rumos da formação ofertada, estabelecendo um estado do conhecimento. Observa-se uma formação não muito distante da já ofertada há décadas nas Universidades Federais, o que coloca em (re)discussão as reais motivações para a inserção de Licenciaturas nos Institutos Federais.
Micro-osteoperforation effectiveness on tooth movement rate and impact on oral health related quality of life:
Authors: Fattori Liana , Sendyk Michelle , de Paiva João Batista , Normando David , Neto José Rino 
Published: July 2020

ABSTRACT

Objectives
To investigate the effect of micro-osteoperforation (MOP) on the rate of tooth movement (RTM), space closure duration, and oral health–related quality of life (OHRQoL) during completion of anterior retraction in patients undergoing combined orthodontic-surgical treatment after premolar extraction and decompensation with sliding mechanics.

Materials and Methods
Twenty-four participants with indications for premolar extractions were randomly allocated to treatment with conventional sliding mechanics (control group; CG) or with to treatment in which three MOPs were performed every activation (experimental group; EG). Dental impressions were taken monthly until space closure was completed and dental casts were converted to three-dimensional models. After the anterior retraction procedure, Oral Health Impact Profile (OHIP-14) questionnaires were filled out at 4 and 72 hours.

Results
Eighteen patients (7 men and 11 women) remained in the trial until space closure was completed (mean follow-up period = 247 days). For full space closure RTM, no significant difference (P = .492) was found between groups (0.614 mm/month for the CG; 0.672 mm/month for the EG). The RTM for different time points, groups, time frames and their interaction were statistically different (P &lt; .05). In multiple correlation analysis, the RTM significantly decreased over time for both groups (P &lt; .05). The OHRQoL scores were significantly higher (worse) for the EG. The psychological, physical and social disabilities, and handicap domains displayed significant differences between the two groups.

Conclusion
Use of MOPs did not change the full space closure RTM, while it had a negative impact on OHRQoL.
LA DIFESA POPOLARE NONVIOLENTA, UN TENTATIVO DI PRESENTAZIONE PARTENDO DALLA VISIONE DI THEODOR EBERT
Authors: ORBÁN Szabolcs 
Published: July 2020

Nonviolent popular defense, an attempt at presentation starting from Theodor Ebert’s vision. Characteristic for the history of humanity is the way people chose to solve conflicts: through violence. Where the stronger one, the better prepared one validates its truth in a way that represents a disadvantage for the weaker, the less prepared one. In the given study, based on Theodor Ebert’s work, we want to present the nonviolent resistance. Based on the examples that come with experience, we would like to formulate some traits, which represent a fundamental element in solving conflicts. Taking Pope Francis’ encouragement in consideration, we would like to find a place for this in the Social Teaching of Church, because we talk about a modality, which provides a chance for the victory of truth regarding the inevitable conflicts of the human society, without violence or putting people’s life in danger.
LO SPARTITO DELLA LIBERTÀ NELLA LETTERA AI GALATI
Authors: AFRENȚOAE Mihai 
Published: July 2020

The Song of liberty in the Letter to the Galatians. With the presentation of freedom and of its opposite, slavery, we tried to understand the reason that caused Paul to write to the Galatians. The research was based on occurrences of eleuth root, which are present in 2: 4; 3: 28; 4: 22, 23, 26, 30, 31; 5: 1, 13, that is, in all its thematic parts: autobiographical, doctrinal and hortatory. In addition to eleuth root, we met two other terms within the same semantic field of freedom or liberation: exelētai, from exaireō, with the meaning of “tear away”, “save”, “free from danger” (1: 4); and exagorasē, from exagorazō, which means “free”, “make good use of” (3: 13; 4: 5). These terms show a multidimensional freedom, condensed in freedom from sin and from this evil eon, as well as from the Jewish Law. The gift of freedom is highlighted by the indicative of salvation obtained in Christ, a gift watched and envied by some false brothers, who had infiltrated in the Galatian communities, in order to lure them into slavery (2: 4). In 3: 10, 13 Paul highlights also the liberation of the obligation of the Law. For Paul, to impose the Jewish Law, with its requirements, it would be synonymous with the return to the elements of the world (4: 3, 9), a return to being children (4: 1), that is, incapable of taking responsibility, worthy of freedom obtained in Christ. The intention of Paul is directed toward the invitation to become mature Christians, passing from the state of nēpios (4: 1) to huiothesia (4: 5b), remaining in the freedom offered from Christ, as a gift. In other words, for Paul, if there is the indicative, it follows also the imperative, as evidenced already in 5: 1, 13, 25, that is, the gift becomes responsibility. From the double aspect of slavery, under the pagan mentality and under the Law, it is evidenced that the freedom in Galatians can be analysed from an anthropological-ethical point of view.
DAS NACHSYNODALE APOSTOLISCHE SCHREIBEN „CHRISTUS VIVIT“ ALS EINE GEGENWÄRTIGE VERWIRKLICHUNG DER DIALOGISCHEN ZIELE DES ZWEITEN VATIKANISCHEN KONZILS
Authors: GENG Noémi 
Published: July 2020

The Apostolic Exhortation Having It’s opening Line Christus Vivit, as a Current Realization of the Dialogue Goal of The Second Vatican Council. The so called „Christus Vivit” apostolic exhortation of Pope Francis linking to the updating objective (actualizing goal) of the Second Vatican Council marks in such way the path of pastoral care for young people, that although it is based on tradition, it is outlined to be adaptive to new situations. Therefore, illuminated by the signs of the times, it shows the way of the outreaching pastoral care. Based on this recognition, in the present study we attempt to illuminate the church’s teaching to youth in the documents of The Second Vatican Council, in the speeches of Pope Francis to them, and in the apostolic exhortation in question.
DAS SUBJEKTSEIN DER KIRCHEN IM KONTEXT EINER TRINITARISCHEN COMMUNIO-EKKLESIOLOGIE
Authors: VIK János 
Published: July 2020

The Subjectivity of the Churches in the Context of a Trinitarian Communio-Ecclesiology. Since the Second Vatican Council, the local Church is no longer regarded as an imperfect part of the universal Church. Rather, the one Church of God is present in every liturgical act of the local Church. The communion of the local Churches (communio ecclesiarum), legitimately marked by their respective traditions and cultures, means unity in diversity and difference. The realization of the program of „participatio actuosa“, i.e. the subject becoming of all in the Church, is in mutual relation to the realization of the communio ecclesiology.
Problema y ejemplo: Los nueve cuadrados y la transformación del edificio fundacional de la Cooper Union
Authors: Estrella Lisseth 
Published: July 2020

Enseñar con el ejemplo es parte fundamental de la estrategia pedagógica de John Hejduk. Sin mayores explicaciones, Hejduk relaciona su proyecto de transformación del edificio fundacional de la Cooper Union con el problema de los nueve cuadrados. Es un caso singular porque el edificio, lugar de la escuela de arquitectura, presenta a sus alumnos el ejemplo del problema utilizado para introducirlos a la arquitectura. Con información de archivo y referencias de personas que formaron parte de la escuela en este período – John Hejduk, Peter Eisenman, Rafael Moneo y Lorna McNeur - el artículo identifica que tanto problema como ejemplo comparten la misma estructura y define el método para relacionarlos: utilizar los nueve cuadrados como herramienta de análisis aplicando los conceptos de centro-periferia, fluidez-contención y estructura-plemento. El resultado del trabajo ha llevado a comprender el contenido analítico del problema en relación con las herramientas del arquitecto: el paso de la planta a la sección en relación con los conceptos de espacio y tiempo.