bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence of a consonant bias during the first year of life: New evidence from own‐name recognition
Authors: Von Holzen Katie , Nazzi Thierry 
Published: April 2020

AbstractRecent evidence suggests that during the first year of life, a preference for consonant information during lexical processing (consonant bias) emerges, at least for some languages like French. Our study investigated the factors involved in this emergence as well as the developmental consequences for variation in consonant bias emergence. In a series of experiments, we measured 5‐, 8‐, and 11‐month‐old French‐learning infants orientation times to a consonant or vowel mispronunciation of their own name, which is one of the few word forms familiar to infants at this young age. Both 5‐ and 8‐month‐olds oriented longer to vowel mispronunciations, but 11‐month‐olds showed a different pattern, initially orienting longer to consonant mispronunciations. We interpret these results as further evidence of an initial vowel bias, with consonant bias emergence by 11 months. Neither acoustic‐phonetic nor lexical factors predicted preferences in 8‐ and 11‐month‐olds. Finally, counter to our predictions, a vowel bias at the time of test for 11‐month‐olds was related to later productive vocabulary outcomes.
Premature loss of primary anterior teeth and its consequences to primary dental arch and speech pattern: A systematic review and meta‐analysis
Authors: Nadelman Patricia , Bedran Natália , Magno Marcela Baraúna , Masterson Daniele , de Castro Amanda Cunha Regal , Maia Lucianne Cople 
Published: April 2020

AbstractBackgroundInformation about the functional and morphological consequences that occur following the premature loss of anterior teeth is still insufficient.AimTo evaluate the consequences in children's speech and arch integrity following premature loss of primary anterior teeth compared to those without premature losses.DesignElectronic searches were performed based on the PECO criteria. Observational studies in children (P) who suffered premature loss or extraction of primary anterior teeth (E) compared to children presenting normal occlusion development (C) and the consequences to speech and dental arch perimeter (O) were included. Risk of bias and data extraction were performed. The meta‐analysis evaluated the influence of premature loss of primary anterior teeth in articulatory speech disorders (distortion, omission, and substitution) and space loss in the dental arches. Random‐ and fixed‐effect models were used, and heterogeneity was tested. The certainty of evidence was estimated using the GRADE approach.ResultsFrom a total of 2.234 studies, six studies were included in the qualitative synthesis, and four in speech disorders meta‐analysis. Despite it was not possible to perform space loss meta‐analysis due to the absence of available data, qualitative analysis showed that there was no space loss after premature loss of mandibular primary incisors; a space loss, however, could be observed in children who lost primary canines at an early stage of dental development. For speech disorders results, children who lost anterior tooth presented higher chance of suffering speech distortion, than children without tooth loss (OR 5.466 [1.689, 17.692] P = .005) with low certainty of evidence. On the other hand, there were no statistically differences between premature loss of primary anterior teeth and omission (OR (a) 1.157 [0.439, 3.049] P = .767 and (OR (b) 1.393 [0.434, 4.70] P = .577) or substitution (OR (a) 1.071 [0.581, 1.974] P = .827 and OR (b) 1.218 [0.686, 2.163] P = .5), both with very low certainty of evidence.ConclusionsPremature loss of primary anterior teeth may affect children phonation causing speech distortion. Consequences of space loss to primary dental arch still need to be further studied. Despite the speech distortion results, included articles present low‐level evidence‐based quality, thus new studies should be performed.
Using Card Games to study cultural differences in men’s social talk about prostate cancer
Authors: Fry Sarah L. , Kelly Daniel , Hopkinson Jane 
Published: April 2020

AbstractAimTo report the Card Games approach used to study men's talk about their risk for prostate cancer and as a method of data collection to analyse patterns of talk among distinct cultural groups.DesignA constructivist grounded theory approach using focus groups to analyse men's social talk about prostate cancer.MethodsData were collected using three focus groups with African‐Caribbean, Somali, and White British men. The focus groups were conducted in a location of the men's choice with a focus group facilitator and observer. Four Card Games were given to the men to encourage social talk.ResultsThe African‐Caribbean men had the most democratic talk with the use of agreement and disagreement and the Somali men were the most inclusive of others and used the most humour. The White British men were competitive in their talk and the least inclusive of each other's views.ConclusionThe Card Games revealed differences in the pattern of talk, which provided insight into how men may use social talk to develop their understanding of prostate cancer risk. This is useful for healthcare professionals as it provides a grounding for structuring discussions with men about prostate cancer, while understanding of how risk‐related knowledge may be reconstructed in social talk and interactions.ImpactThe methodology discussed in this paper addressed the use of focus group to analyse talk of men from culturally diverse groups. The use of Card Games allowed the talk between the men to take centre stage and this allowed differences in the social talk of the men to become apparent. The use of this methodology could have an impact on approaches to researching cultural understandings of cancer risk, which may provide evidence on effective delivery of sociocultural relevant health education relating to cancer screening.
A novel lncRNA PLK4 up‐regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP‐mediated cell senescence
Authors: Jia Yan , Jin Huanhuan , Gao Liyuan , Yang Xiang , Wang Feixia , Ding Hai , Chen Anping , Tan Shanzhong , Zhang Feng , Shao Jiangjuan , Wang Shijun , Zheng Shizhong 
Published: April 2020

AbstractA growing number of studies recognize that long non‐coding RNAs (lncRNAs) are essential to mediate multiple tumorigenic processes, including hepatic tumorigenesis. However, the pathological mechanism of lncRNA‐regulated liver cancer cell growth remains poorly understood. In this study, we identified a novel function lncRNA, named polo‐like kinase 4 associated lncRNA (lncRNA PLK4, GenBank Accession No. RP11‐50D9.3), whose expression was dramatically down‐regulated in hepatocellular carcinoma (HCC) tissues and cells. Interestingly, talazoparib, a novel and highly potent poly‐ADP‐ribose polymerase 1/2 (PARP1/2) inhibitor, could increase lncRNA PLK4 expression in HepG2 cells. Importantly, we showed that talazoparib‐induced lncRNA PLK4 could function as a tumour suppressor gene by Yes‐associated protein (YAP) inactivation and induction of cellular senescence to inhibit liver cancer cell viability and growth. In summary, our findings reveal the molecular mechanism of talazoparib‐induced anti‐tumor effect, and suggest a potential clinical use of talazoparib‐targeted lncRNA PLK4/YAP‐dependent cellular senescence for the treatment of HCC.
Understanding patients’ experiences of being mechanically ventilated in the Intensive Care Unit: Findings from a meta‐synthesis and meta‐summary
Authors: Danielis Matteo , Povoli Arianna , Mattiussi Elisa , Palese Alvisa 
Published: April 2020

AbstractAims and objectivesTo synthesise the evidence reported in qualitative studies concerning the lived experiences of adult patients receiving mechanical ventilation in Intensive Care Unit (ICU).BackgroundCritically ill patients receiving mechanical ventilation in the ICU have been reported to suffer from severe physical and emotional responses such as hopelessness, anxiety, high levels of frustration and stress. Recent improvements in the field of mechanical ventilation and sedative medications as experienced by patients that can inform nursing care have not been summarised to date.DesignA systematic review of qualitative studies followed by a meta‐synthesis and a meta‐summary was performed.MethodsFour electronic databases were searched by two authors in June 2019. A total of nine studies were included and evaluated based on their methodological quality using the Critical Appraisal Skills Programme checklist.ResultsA total of 24 codes emerged from the abstraction process, which were categorised into 11 categories and four themes: (a) “The effect of the intense stress on the body's systems,” (b) “The induced negative emotional situations,” (c) “The feeling of being cared for in a hospital setting” and (d) “The perceived support from the family and loved ones.” Furthermore, the most frequent codes across studies were “Being afraid,” “Feeling supervised,” “Feeling comforted,” “Failing to communicate,” and “Experiencing difficulties in breathing,” with an intensity of 66.6%.ConclusionPatients receiving mechanical ventilation have expressed a general sense of vulnerability, of which critical care nurses need to be aware.Relevance to clinical practiceFindings suggest the need for improvements at the nursing, unit, educational and policy levels; furthermore, more research is also required at the international levels given the current trends towards no sedation protocols for the management of ICU patients: listening to their experiences becomes imperative, in order to ensure an awake, comfortable and ventilator‐tolerant patient.
Effects of Health Belief Model based nursing interventions offered at home visits on lymphedema prevention in women with breast cancer: A randomised controlled trial
Authors: Cal Ayse , Bahar Zuhal , Gorken Ilknur 
Published: April 2020

AbstractBackgroundLymphedema is an important morbidity due to its physical and psychological restrictions and financial burden in women having breast cancer surgery. The study was performed to examine effects of Health Belief Model (HBM) based nursing interventions given at home visits on prevention of lymphedema in women having breast surgery.DesignThe study had an experimental design.MethodsThe study included 72 women receiving radiotherapy after breast surgery, of whom 37 formed the intervention group and 35 formed the control group. The sample was based on Consolidated Standard of Reporting Trials (CONSORT). Data were collected with a personal information questionnaire, Quick‐Disabilities of the Arm, Shoulder and Hand Score (Q‐DASH), European Organization for Research and Treatment of Cancer Quality of Life for Breast Cancer 23 (EORTC QLQ‐BR23), Strategies Used by Patients to Promote Health (SUPPH), Arm Circumference Form at three home visits at 3‐month intervals.ResultsHBM based nursing interventions regularly offered at home visits were found to create positive changes in behaviour of lymphedema prevention and improve upper extremity functions, reduce side‐effects, relieve arm and breast symptoms, enhance the quality of life, increase self‐efficacy and lower the frequency of lymphedema and costs.ConclusionThe HBM based nursing interventions regularly offered at home visits can create positive changes in behaviour of lymphedema prevention and prevent lymphedema in women receiving radiotherapy after breast surgery. Considering costs of treatment for lymphedema, these interventions can be considered as cost‐effective.Relevance to clinical practiceNursing interventions directed towards behaviour of preventing lymphedema and follow‐ups in the long‐term should be supported by home visits and reminders through phone calls. Nurses should perform HBM based interventions regularly at home visits to prevent lymphedema. These interventions were found to reduce financial burden and were cost‐effective.
Computerised occlusal analysis of mini‐dental implant‐retained mandibular overdentures: A 1‐year prospective clinical study
Authors: Kabbua Phongkamon , Aunmeungtong Weerapan , Khongkhunthian Pathawee 
Published: April 2020

AbstractOcclusal analysis is a substantial tool for the functional improvement evaluation after using implant‐retained overdenture comparing to complete denture without dental implant retaining. To evaluate occlusal pattern, chewing force distribution in mini‐dental implant‐retained mandibular overdentures by computerised occlusal analysis system and to compare patient satisfaction after 1‐year function. Thirty‐one patients wearing complete dentures were included in the study. Prior to mini‐dental implant‐retained treatment, all patients were assessed for occlusion and force distribution using computerised occlusal analysis system (T‐Scan®), and then, all patients received two mini‐dental implant‐retained mandibular overdentures. Mini‐dental implants were immediately loaded using low vertical profile attachments (Equator®). T‐Scan® was used to evaluate chewing force and force distribution at 1 day, 3 months, 6 months and 12 months. The patient satisfactions before implant placement and after 1 year were evaluated using questionnaires which included satisfaction of denture quality, psychosocial behaviour and chewing efficiency modified from the validated questionnaires. Clinical evaluation of two mini‐dental implant‐retained mandibular overdentures showed 100% success rate after 1 year. T‐Scan® demonstrated that maximum occlusal contact force increased continuously. The force distribution; the tooth contact number increased over the period. At 1‐year follow‐up, overall patient satisfaction was significantly greater than before receiving mini‐dental implant treatment (P < .001). Using computerised occlusal analysis, mini‐dental implants improve complete denture function significantly in terms of maximum occlusal contact force, tooth contact number without the impairment of force distribution. The oral function of the patients has been enhanced.
Changes in occlusal surface area and occlusal force distribution following the wear of vacuum‐formed, hawley and bonded retainers: A controlled clinical trial
Authors: Alkan Özer , Kaya Yeşim 
Published: April 2020

AbstractTo evaluate the changes in occlusal surface area (OSA) and occlusal force distribution (OFD) following the wear of Vacuum‐formed (VFR), Hawley (HR) and Bonded (BR) retainers, using T‐Scan III. A total of 60 subjects using three different maxillary and mandibular orthodontic retainers, VFR (n:20), HR (n:20) and BR (n:20), were included in this study. The changes in OSA and OFD were evaluated using the T‐Scan III. The evaluations were made 2 hours after debonding orthodontic appliances (T0) and in the 3rd (T1) and 6th (T2) months of the retention phase. For left (LDA), right (RDA) and posterior dental arches (PDA), intragroup comparison of OSA showed significant increase in the VFR and HR groups at T1‐T2 and T0‐T2 time intervals and in the BR group at T0‐T1 and T0‐T2 time intervals. For the anterior dental arch (ADA), only the increase in the HR group at T0‐T1 and T0‐T2 time intervals was found significant. When compared between the groups, the changes between HR and BR groups detected at T1‐T2 time interval for the RDA and at T0‐T1 and T0‐T2 time intervals for the ADA were found significant. Intragroup comparison of OFD displayed significant changes only in the BR group. At T0‐T1 time interval, the decrease in the ADA and the increase in the PDA were found significant. Also, intergroup OFD comparison exhibited significant differences between HR and BR groups at T0‐T1 time interval for ADA and PDA. Although no significant differences were found between the VFR group, the increase in OSA occurred faster in the PDA in the BR group, whereas in the ADA it was significant only in the HR group.
A nurse‐driven analgesia and sedation protocol reduces length of PICU stay and cumulative dose of benzodiazepines after corrective surgery for tetralogy of Fallot
Authors: Hanser Anja , Neunhoeffer Felix , Hayer Tobias , Hofbeck Michael , Schlensak Christian , Mustafi Migdat , Kumpf Matthias , Michel Jörg 
Published: April 2020

AbstractPurposeAnalgesia and sedation protocols are reported to reduce the requirement of sedative and analgesic agents, duration of mechanical ventilation, and length of pediatric intensive care unit (PICU) stay. However, these studies often were conducted based on inhomogeneous cohorts. The aim of this study was the evaluation of a nurse‐driven analgesia and sedation protocol in a homogenous population of infants following corrective surgery for tetralogy of Fallot (TOF).Design and MethodsThis retrospective analysis was conducted in a cardiac PICU of a tertiary referral center. Two cohorts of patients who underwent corrective surgery for TOF below the age of 7 months, were retrospectively evaluated before and after implementation of a nurse‐driven analgesia and sedation protocol. We compared peak and cumulative doses of midazolam, morphine, and clonidine, length of PICU stay and time on mechanical ventilation.ResultsA total of 33 patients were included in the preimplementation period and 32 during the postimplementation period. Implementation of the nurse‐driven analgesia and sedation protocol had no effect on time on mechanical ventilation (72 hr [24–141] vs. 49 hr [24–98]), but significantly on length of PICU stay (7 days [5–14] vs. 5 days [4–7]). Cumulative doses of midazolam (7.37 mg/kg [4.70–17.65] vs. 5.0 mg/kg [2.70–9.12]) as well as peak doses of midazolam (0.22 mg·kg−1·hr−1 [0.20–0.33] vs. 0.15 mg·kg−1·hr−1 [0.13–0.20]) and morphine (50.0 µg·kg−1·hr−1 [39.7–79.9] vs. 42.5 µg·kg−1·hr−1 [29.7–51.8]) were significantly reduced. The postimplemantation group showed no increase in postoperative complications and adverse events.Practice ImplicationsThe implementation of a nurse‐driven analgesia and sedation protocol is safe in infants following corrective surgery for TOF. It reduces significantly the length of PICU stay, cumulative and peak doses of midazolam and peak doses of morphine.
ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats
Authors: Luis Fuentes Virginia , Abbott Jonathan , Chetboul Valérie , Côté Etienne , Fox Philip R. , Häggström Jens , Kittleson Mark D. , Schober Karsten , Stern Joshua A. 
Published: April 2020

AbstractCardiomyopathies are a heterogeneous group of myocardial disorders of mostly unknown etiology, and they occur commonly in cats. In some cats, they are well‐tolerated and are associated with normal life expectancy, but in other cats they can result in congestive heart failure, arterial thromboembolism or sudden death. Cardiomyopathy classification in cats can be challenging, and in this consensus statement we outline a classification system based on cardiac structure and function (phenotype). We also introduce a staging system for cardiomyopathy that includes subdivision of cats with subclinical cardiomyopathy into those at low risk of life‐threatening complications and those at higher risk. Based on the available literature, we offer recommendations for the approach to diagnosis and staging of cardiomyopathies, as well as for management at each stage.
Acculturation and health behaviors among older Chinese immigrants in the United States: A qualitative descriptive study
Authors: Mao Weiyu , Li Jia , Xu Ling , Chi Iris 
Published: April 2020

AbstractOlder immigrants tend to experience rapid deterioration in health after immigration. Changes in health behaviors over the course of acculturation are considered attributable factors. However, much remains unknown when it comes to acculturation experiences and health behaviors among older immigrants. This study explored acculturation in three domains (behavioral, cognitive, and identificational) and described how each domain of acculturation could influence various health behaviors among community‐dwelling older Chinese immigrants in the United States. In this qualitative descriptive study, trained bilingual interviewers conducted in‐depth individual interviews with 24 participants in the greater Los Angeles area. Acculturation experiences emerged from qualitative content analysis, such as high dependence on Chinese behavioral patterns and intraethnic networks and limited intergroup interactions (behavioral acculturation), strong maintenance of Chinese cultural values and some American cultural learning (cognitive acculturation), and strong identification with Chinese ethnicity (identificational acculturation). Behavioral acculturation and cognitive acculturation may influence various health behaviors, including eating/diet, exercise, chronic disease, and mental health management. By recognizing the unique acculturation experiences, interventions could be developed to promote healthy behaviors in achieving optimal health in this population.
Early clinical, histological, and immunohistochemical findings in suspected acute graft‐versus‐host disease and their association with patient outcomes
Authors: García‐Romero Maria Teresa , Sáez‐de‐Ocariz Marimar , Hernández‐Zepeda Carolina , Reyes Montserrat , García de la Puente Silvestre , Ridaura‐Sanz Cecilia , López‐Hernández Gerardo , Olaya‐Vargas Alberto 
Published: April 2020

AbstractBackground/ObjectivesAcute graft‐versus‐host disease (aGVHD) is a serious condition after allogeneic hematopoietic stem cell transplantation (HSCT), frequently involving skin, gut, and liver. It can be difficult to diagnose early, yet this is vital for adequate management. We sought to identify initial clinical and histopathological features in children with suspected GVHD and the association with clinical course and outcomes.MethodsRetrospective study of patients with skin biopsies for suspected aGVHD from 2006 to 2016. We collected demographic and clinical information, histologic, and immunohistochemical (IHC) findings, and outcomes during follow‐up. Bivariate and multivariate analyses were done to identify risk factors associated with remission, development of severe/life‐threatening aGVHD, and mortality.ResultsWe included 42 patients, 15 females. Skin manifestations occurred 51 days (median) after HSCT. On biopsy, 76.2% had mild (stage 1‐2) skin aGVHD; during the course of the disease, severity and systemic involvement increased to global grade III/IV in 66.6%. All patients received treatment; 15 are in remission from aGVHD and 23 have died. Histologic features were diagnostic in 83.3%. On bivariate and multivariate analysis, we identified initial clinical and histologic findings that were associated with the measured outcomes: odds of remission from aGVHD were increased when focal vacuolar changes were found on skin biopsy (OR 6.028; 95%CI:1.253‐28.992) but decreased by initial hepatic aGVHD (OR 0.112; 95%CI: 0.017‐0.748); severe/life‐threatening aGVHD was associated with initial gastrointestinal aGVHD (OR 6.054; 95%CI:1.257‐29.159); and odds of mortality were decreased with male donor (OR 0.056; 95%CI:0.004‐0.804), nulliparous female donor (OR 0.076; 95%CI:0.009‐0.669), and focal vacuolar changes on skin biopsy (OR 0.113; 95%CI:0.017‐0.770).ConclusionsWe found novel indicators predictive of remission, severity, and mortality in children with aGVHD. Further studies of this condition in children are needed.