bluuebunny/crossref_metadata_2025_split huggingface dataset:
Husband’s Experiences of Recurrent Pregnancy Loss in Japan: A Qualitative Study
Authors: Hada Kumiko , OHIRA Mitsuko , NAKATSUKA Mikiya 
Published: October 2020

Abstract
Background: Miscarriage or stillbirth is an experience of losing a child. However, in a clinical setting, men are positioned to support women. Therefore, mental support for men is insufficient. It is predicted that marital mourning in men will affect marital relations if it does not go smoothly. This study aimed to clarify the experiences of husbands in couples suffering from recurrent pregnancy loss (RPL) in Japan and clarify the support based on the husband’s needs.Methods: Semi-structured interviews were conducted with 14 husbands attending the outpatient treatment for RPL at visiting clinic of a University Hospital A in City A. The interview data were analyzed using a qualitative descriptive approach.Results: The husbands’ experiences were classified into 13 categories. Based on the interview data, the husbands felt shock of first pregnancy loss, and then while experiencing lingering anxiety regarding pregnancy loss and feeling less grief over subsequent pregnancy losses, they made an effort to accept recurrent loss. Husbands were feeling apologetic to one’s wife, resulting in prioritizing one’s wife and performing actions toward wife with good intentions. Moreover, after experiencing repeated pregnancy losses, husbands felt feelings of hopelessness caused by RPL, while craving for a child and giving up on having a child, and experiencing difficulty faced in sexual relations while maintaining a distant but steady marital relationship. Husbands were hoping that family members would quietly offer support and engaged in stance at work of not wanting people to mention RPL.Conclusions: The husband with RPL supported his wife while suffering from the mental burden of a miscarriage or stillbirth and was isolated in a relationship. Medical professionals should be able to advocate for husbands in couples suffering from RPL to help them voice their feelings to their wives; moreover, frameworks need to be established to support good marital relationships and psychologically support the husbands of such couples.
Risk factors for FN, mucositis and esophagitis of combination chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for esophageal cancer
Authors: Yuda Sayako , Kato Ken , Sasaki Yusuke , Takahashi Naoki , Shoji Hirokazu , Takashima Atsuo , Okita Natsuko , Honma Yoshitaka , Iwasa Satoru , Hamaguchi Tetsuya , Nagashima Kengo , Boku Narikazu 
Published: October 2020

Abstract
BackgroundAddition of docetaxel to cisplatin plus 5-fluorouracil (DCF regimen) for treatment of esophageal carcinoma can improve the clinical outcome, but it is associated with increased toxicity. The risk factors for severe toxicities associated with DCF treatment remain unknown.MethodsWe retrospectively reviewed the data of esophageal cancer patients who received DCF between July 2009 and April 2014 at the National Cancer Center Hospital. Docetaxel 70 mg/m2/day (day 1), cisplatin 70 mg/m2/day (day 1), and continuous infusion of 5-fluorouracil 750 mg/m2/day (days 1–5) were administered every 3 weeks. The risk factors for severe adverse events were explored.ResultsWe included 100 patients with a median age of 63 years (range: 37–76), among whom 81 were men, and 44 and 55 had performance status scores of 0 and 1, respectively. A total of 96 patients had squamous cell carcinoma, while 4 had adenocarcinoma. A total of 1, 12, 64, and 23 patients had clinical stages I, II, III, and IV, respectively. DCF was used as neoadjuvant therapy in 69 patients, induction before chemoradiotherapy in 23, and palliative in 8. Approximately 45 patients experienced grade 4 hematological adverse events, while 40 developed grade >3 non-hematological adverse events: anorexia, 12%; mucositis, 6%; and esophagitis, 2%. Multivariate analysis showed a significant association between dysphagia score >2 (P = 0.022) and febrile neutropenia, and between platelet count ≤27,500/µl and grade >3 mucositis and/or esophagitis (P = 0.007).ConclusionDuring DCF therapy, patients with dysphagia or decreased platelet count should be carefully managed.Trial registration: Not applicable
Identification of key gene in colorectal cancer using bioinformatics analysis.
Authors: Xiao Rongrong , Wang Ping , Xia Tian , Li Chun-Yi , Jiang Ting , Huang Xin-en 
Published: October 2020

Abstract
Background

Tumor microenvironment plays important roles in the development of cancer. The aim of our study was to examine the expression of genes in colorectal cancer and also to evaluate the association value between expression level of these genes and clinical features.
Methods

We combined The Cancer Genome Atlas (TCGA) datasets to identify differentially expressed genes in colon cancer. Using these differentially expressed genes, we constructed protein-protein interaction network and conducted functional enrichment analysis. Genes with degree beyond 10 in the PPI network were regarded as hub genes. Then, we verified of the expression of molecules in Oncomine datasets and conducted Kaplan-Meier curve and log-rank test and functional enrichment analysis on these hub genes. Finally, we analyzed the relationship clinicopathological features analysis with the key gene.
Results

There were 719 differentially expressed genes identified to be associated with colon cancer microenvironment. We screened out 10 hub genes by construction of PPI network. The functions of these hub genes were enriched in cytokine-cytokine receptor interaction, alcoholism and systemic lupus erythematosus, which provided further insight into the roles of these genes in the tumor microenvironment. GNG4, with the highest degrees in the PPI network, were highly exprepressed in metastasis(P = 9.5-05) ,N1(P = 0.0025) and N2(,0.037).It was a relationship with stage. It was significantly different between with stage I and IV, II and III, II and IV,III and IV (P = 0.0015,0.029,3.9-05,0.00074,0.01,respectively)
Conclusions

We identified GNG4 can be regarded as a prognostic biomarker in colon cancer.
Maximizing Acceptance of Clinical Pharmacy Recommendations May Reduce The Length of Hospital Stay in A Private Hospital From Amman, Jordan: Toward Fully Independent Pharmacist Prescribers
Authors: Saadah Loai , Khan Amer Hayat , Sulaiman Syed Azhar Syed , Basheti Iman Amin 
Published: October 2020

Abstract
Background: Clinical pharmacy interventions (CPI) usually require prior medical authorization with 20% being rejected. If pharmacists prove to be more competent in this area (accept 100% of CPI), the profession will step closer to a fully-independent prescriber status. Objective: This study use an artificial neural network (ANN) model to determine whether clinical pharmacy (CP) may improve outcomes associated with rejected CPI. Setting: This is a non-interventional, retrospective analysis of documented CPI in a 100-bed, acute-care private hospital in Amman, Jordan.Method: Study consists of 542 patients, 574 admissions, and 1694 CPI. Team collected demographic and clinical data using a standardized tool. Input consisted of 54 variables with some taking merely repetitive values for each CPI in a given patient whereas others varying with every CPI. Therefore, CPI was consolidated to one rejected and/or one accepted per patient per admission. Groups of accepted and rejected CPI were compared with matched and unmatched variables. ANN were, subsequently, trained and internally as well as cross validated for outcomes of interest. Outcomes were length of hospital and intensive care stay after the index CPI (LOSTA & LOSICUA, respectively), readmissions, mortality, and cost of hospitalization. Best models were finally used to compare the two scenarios of approving 80% versus 100% of CPI. Variable impacts (VI) automatically generated by the ANN were compared to evaluate the effect of rejecting CPI. Main outcome measure: Lengths of hospital stay after the index CPI (LOSTA).Results: ANN configurations converged within 18 seconds and 300 trials. All models showed a significant reduction in LOSTA with 100% versus 80% accepted CPI of about 0.4 days (2.6 ± 3.4, median (range) of 2 (0 – 28) versus 3.0 ± 3.8, 2 (0 – 30), P-value = 0.022). Average savings with acceptance of those rejected CPI was 55 JD (~ 78 US dollars) and could help hire about 1.3 extra clinical pharmacist full-time equivalents. Conclusion: Maximizing acceptance of CPI reduces the length of hospital stay in this model. Pharmacists seem to be well-positioned to target gain the upper hand on prescribing in these situations.
Quantitative Immunohistochemical Expression of GP88 in Invasive Ductal Carcinoma (IDC) of Human Breast Cancer
Authors: Yehia Mona Abdel-Hamed , El-Fiky Shawky Mohamed , AL-Qadasi sabah Ali , Sedfy Amel Sobhey El- 
Published: October 2020

Abstract
Background: Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues, as well as, its correlation with different pathological parameters.Methods: The immunohistochemical avidin-biotin complex protocol of the paraffin section was used to detect the expression of GP88 and HER2/neu in IDC of 60 patients, 30 benign, and ten normal breast tissues. Results: the study showed a high expression of GP88 in IDC comparing to normal and benign breast tissues. A higher significant statistical correlation between the expression of GP88 and large tumor size, tumor grade, and lymph node metastasis (LNM). While a negative statistical correlation was noticed between the expression of GP88 and ER, PR, and HER2/neu status.Conclusion: It could be concluded that GP88 glycoprotein may be a valuable predictive and therapeutic marker in human IDC patients.
Moment-Based Analysis of Reg. Triangular QAM in Turbulent Atmospheric Channels with Pointing Errors incorporates Zero and Non-zero Boresight
Authors: Shahid Muhammad Nabeel , Qureshi Furqan Haider , Sheikh Shahzad Amin , Khan Qasim Umar , Zeeshan Muhammad 
Published: October 2020

Abstract
In recent years, free-space optical (FSO) technology has gained fame in communication systems due to its high data rates and license-free feature. Triangular quadrature amplitude modulation (TQAM) is an efficient modulation scheme that uses even bits per symbol, and it has a low average symbol error rate (ASER) than square quadrature amplitude modulation (SQAM). In this paper, we theoretically investigate the performance of subcarrier triangular quadrature amplitude modulation (SC-TQAM) corrupted by atmospheric turbulence in the presence of pointing errors (P.E) in FSO communications. We have considered boresight displacement, P.E effect, and atmospheric turbulence. To represent the atmospheric turbulence we consider Log-normal, Rayleigh and Rician distributions which exhibit weak, moderate and strong weather effects. The P.E is employed using Rayleigh and Rician distribution that incorporates zero and non-zero boresight displacement respectively. The moment generating functions of these models have been derived. P.E is modeled using an optical beam radius and receiver aperture radius. The combination of these parameters will help enhance the average symbol error rate (ASER). Furthermore, we have derived an analytical expression that is used to develop numerical results. The ASER performance is observed against average received irradiance, optical beam radius, P.E standard deviation and receiver aperture radius. In the end, the ASER performance is evaluated against SNR and Monte Carlo simulations are performed which validates the theoretical results.
Characterization and Comparative Analysis of Transcriptional Profiles of Porcine Colostrum and Mature Milk Across Multiple Parities
Authors: Keel Brittney N , Lindholm-Perry Amanda K , Oliver William T , Wells James E , Jones Shuna A , Rempel Lea A 
Published: October 2020

Abstract
BackgroundThe expression of genes and their regulation during lactation in swine is not well-understood. In order to gain a better understanding of genes and pathways involved in sow lactation, total RNA from colostrum and mature milk samples were sequenced from 65 sows across four parities. A stringent bioinformatic pipeline was used to identify and characterize 44,234 transcripts. ResultsThe 44,234 identified transcripts included 41,875 previously annotated transcripts and 2,359 novel transcripts. Differential gene expression analysis was conducted using a generalized linear model coupled with the Lancaster method for P-value aggregation across transcripts. In total, 1,900 differentially expressed genes (DEG) were identified for the milk type main effect, and 373 DEG were identified for the milk type x parity interaction. Several gene ontology (GO) terms related to immune response were significant for the milk type main effect, supporting the widely-accepted hypothesis that immunoglobulins and immune cells are transferred to the neonate via colostrum.ConclusionsThis is the first study to perform global transcriptome analysis from whole milk samples in sows from multiple parities. Our results provide important information and insight into synthesis of milk proteins and innate immunity and potential targets for future improvement of swine lactation and piglet development.
Noncommunicable Diseases in The Southwest of Iran, A Region of High Altitude with Distinctive Ethnic Groups: Results of The Shahrekord Cohort Study
Authors: Ahmadi ALI 
Published: October 2020

Abstract
Background: Critical inter-provincial differences within Iran in the pattern of noncommunicable diseases (NCDs) and difficulties inherent to the identification of prevention methods to reduce mortality from NCDs have challenged the implementation of the provincial health system plan. The Shahrekord Cohort Study was designed to address these gaps in Chaharmahal and Bakhtiari, a province of high altitude of the southwest of Iran, characterized by its large Bakthiari population.Methods: This ongoing cohort, prospective longitudinal study is a unique, rich biobank and a large-scale study conducted for the first time in Chaharmahal and Bakhtiari province in Iran. The study began in 2015, recruited 10075 participants (52.8% female) from both urban and rural (30.2%) areas and participants will be followed up until at least 2035. Diseases and their outcomes are ascertained from clinical examinations, interviews, and linkage with medical records registered in the health system.Results: Preliminary results indicate that the prevalence of NCDs at baseline was relatively high, for example 10.7% for type 2 diabetes mellitus, 20.2% for hypertension, 14.6% for non-alcoholic fatty liver, 11.4% for thyroid disease, and 5.7%, 0.9% and 1.3% for ischemic heart disease, stroke and myocardial infarction respectively. The mean (standard deviation) of BMI, systolic blood pressure, fasting blood glucose and cholesterol were 27.6 (4.6) kg/m2, 115.4 (17.3) mmHg, 96.7 (27.3) mmol/L and 184.1 (42.8) respectively. All NCDs appeared to be more frequent in urban than rural areas, except gastroesophageal reflux (32.3% in rural and 29% in the urban area). Conclusions: The Shahrekord Cohort Study provides a platform for epidemiological studies that will be useful for a better prevention and management of NCDs in the southwest of Iran.
A Rare Case Report: Triethylamine Poisoning and The Pharmaceutical Care
Authors: Lin Yanhua , Jiang Huaqiao , Fang Zhonghong 
Published: October 2020

Abstract
Background: Triethylamine is an important intermediate reactant and is widely used in industry and manufacturing. So far, cases of triethylamine poisoning timely saved are rarely reported.Methods: A 29-year-old male worker from a chemical plant after taking a small sip of triethylamine was presented in ICU. Subsequently, he experienced repeated vomiting, abdominal pain, gastrointestinal bleeding and other related injuries. Owing to no significant improvement in local hospital, he was transferred to Jinshan hospital, Fudan University for better medical treatment. He received hemostasis, PPIs for gastrointestinal mucosal recovery, blood purification for poison removal, nutritional and electrolyte supplement after admission. The author participates in treatment and analyzes clinical results in order to share treatment methods and experience for similar poisoning events in future.Results: His gastrointestinal bleeding was timely controlled, his pain and other poisoning symptoms were eliminated. And he was discharged home safely. Conclusions: Triethylamine can break the gastric mucosal barrier, the administration of proton pump inhibitors (PPIs) had a great importance. The timely blood purification for him helped eliminate the residual chemical poison inside his body, so his further liver injury by triethylamine was prevented. His recovery is good.
3D Reaching Movements Prediction of Upper-limb Joints Based on Deep Neural Networks
Authors: Wang Chao , Xie Shengquan , Bao Tianzhe , Sivan Manoj 
Published: October 2020

Abstract
BackgroundThe reaching test is widely adapted in motor function assessment of stroke rehabilitation. To evaluate the motor disorder quantitatively, it is important to measure the differences between reaching movements made by healthy people and patients. Thus a movement prediction model should be firstly established on healthy people as a customized benchmark. MethodsWe designed a simplified kinematic model for human upper limbs in which seven main joints of both the dominant and non-dominant side were extracted. With this model, the reaching movement data was collected from a healthy participant. A deep neural network (DNN) was trained with this dataset. Then, the DNN was utilized for predicting 3D movements of upper limb joints of a healthy participant. ResultsThe prediction trajectories of dominant side were high similar to the trajectories of real movements with the coupling distance around 60 mm, 50 mm, 30 mm, 30 mm, 20mm for hand, elbow, shoulder, 7th cervical vertebra and 8th thoracic vertebra. The result of non-dominant side were less accurate than dominant side but still was with relatively short coupling distance. ConclusionsThe DNN model could achieve the promising accuracy in 3D movements estimation of upper limb. With good capabilities of identifying specific reaching movements in dynamic processing, a customized benchmark established by data-driven methods could be utilized to inform the rehabilitation assessment and training in the future studies.
Hyperexpression and Hypomethylation of TM4SF1&nbsp;Are Associated With Lymph Node Metastases in Papillary Thyroid Carcinoma Patients
Authors: Wang Kun , Zheng Juan , Wu Zhen , Fang Jugao , Zhao Junyu , Yao Jinming , Dong Jianjun , Liao Lin 
Published: October 2020

Abstract
Background: Lymph node metastases(LNM) is an indicator for recurrence in papillary thyroid carcinoma(PTC) patients.However,prophylactic neck dissection(ND) can not improve neither survival nor recurrence rate because of increased surgical complications and occult lymph node metastases.Biomarkers are needed for prediction of high-risk of LNM to avoid unnecessary operation and reduce the missed malignant lymph nodules.Methods: GEO database was searched for the differentially expressed genes (DEGs) between PTC patients with LNM(N1) and those without LNM(N0),transcriptional and methylation data of DEGs in THCA were examined from databases.The expression and methylation of TM4SF1 in fresh and paraffin tissues of PTC paitents were examined by qRT-PCR、IHC and MSP.Results: TM4SF1 was the only one significantly associated with LNM.Ualcan revealed that TM4SF1 was overexpression and hypomethylation in LNM patients.MEXPRESS presented a negative correlation between gene expression and promoter methylation of TM4SF1.DEGs were enriched to multiple pathways and Extracellular Matrix(ECM)-receptor interaction ptahway showed the greatest correlation with LNM.IHC and qRT-PCR of tissues demonstrated that the expression of TM4SF1 in N1 group were 4.5-fold higher than that in N0 group (P<0.05).MSP exhibited that the the positive rate of aberrant promoter methylation of TM4SF1 were 8.38% in N1 and 66.7% in N0 group(P<0.05).Conclusions: Hyperexpression and hypomethylation of TM4SF1 are associated with lymph node metastases in PTC patients.
Temporal coherence of mechanical stimulation modulates tactile form perception
Authors: Nakatani Masashi , Kobayashi Yasuaki , Ohno Kota , Uesaka Masaaki , Mogami Sayako , Zhao Zixia , Sushida Takamichi , Kitahata Hiroyuki , Nagayama Masaharu 
Published: October 2020

Abstract
The human hand can detect both the form and texture of the contact surface. The detection of skin displacement (sustained stimulus) and change in skin displacement (transient stimulus) are thought to be mediated in different tactile channels; however, tactile form perception may use both channels to reconstruct an unified tactile imagery of contact surface in the brain. Here, we studied whether the temporal frequency and temporal coherence information of tactile stimuli encoded in sensory neurons could be used to recognize the form of the contact surface. We used a known tactile phenomenon, the fishbone tactile illusion (FTI), as a probe for tactile perception in humans. It uses an archetypal surface geometry that has a smooth central bar and textures (ridges and grooves) in its adjacent areas. By stroking the central bar back and forth with a fingertip, an observer typically perceives an indented surface geometry even though the bar is physically flat. We used a passive high-density pin matrix to extract only the vertical information of the contact surface, while excluding any tangential force caused by rubbing the surface. Participants in the psychological experiment reported the indented surface geometry by tracing the FTI textures with pin matrices of different spatial densities (1.0- and 2.0- mm pin intervals). Participants reported a steep decrease in the relative magnitude of the indented surface geometry when pins in the adjacent areas vibrated synchronously. To investigate possible mechanisms for tactile perception in the FTI, we developed a computational model of sensory neurons to estimate temporal patterns of action potentials from tactile receptive fields. Our computational data suggest that i) the temporal asynchrony of sensory neuron responses correlated with the relative magnitude of indented geometric perception, and ii) the temporal change of displacements in tactile stimuli correlated with the asynchrony of simulated sensory neuron responses for the fishbone surface patterns. Based on these results, we suggest that both the temporal frequency and asynchrony of activity in sensory neurons could produce tactile form perception.