bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Characterization of Biphasic Materials With Different Granulation Sizes and Their Influence on Bone Repair and Inflammation in Rat Calvaria
Authors: Junior Joviniano Oliveira , Montagner Pedro , Carrijo Rafael , Martinez Elizabeth 
Published: December 2020

Abstract
Biphasic calcium phosphate bioceramics (BCP) consist of a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) within the same particle. Due to their osteoconductive properties, biocompatibility and resemblance to natural bone, these materials have become a promising and suitable alternative to autologous bone grafting. First, the topography characteristics, specific surface area, and total pore volume of BCP were evaluated using scanning electron microscopy and the BET and BJH methods. Next, this study aimed to evaluate the intensity of the inflammatory process and the bone neoformation capacity of various particle sizes of BCP in the repair of critical defects in the calvaria of rats. A xenogeneic biomaterial was used in the control group. After 30, 60, and 90 days, the animals were euthanized, followed by the processing of the samples to measure the intensity of inflammatory infiltrates and the areas of bone neoformation. Our results indicate that no considerable differences were observed in the inflammatory scores in sites treated with distinct BCP grain sizes. A greater area of bone neoformation was measured in the xenogeneic group at all analysis times, with no substantial differences in bone formation between the BCP particle size in the range of 250–500 µm and 500–1000 µm.
Factors Influencing Snacking Practices of Pre-schoolers in Bangkok, Thailand: A Qualitative Study
Authors: Yothasamut Jomkwan 
Published: December 2020

Abstract
Background: The National Health Examination Survey 2014 revealed 11.3% of children aged 1-5 years in Thailand were overweight and obese. Few studies explored sociocultural factors that creates obesogenic environment. This study aims to understand the mechanisms of factors influencing childhood obesity.Methods: A qualitative inductive approach was employed for data collection designed to capture the temporal and spatial specificity of snacking. Participant observation and informal interviews were data collection methods. Three kindergartens used by families of varying socio-economic status, and the homes of 18 pre-schoolers attending these kindergartens were settings of this study.Results: Channels where children could obtain snacks included routine snacks at kindergarten, snacks that children can bring from home to eat and share with peers, and snacks that children can buy on the way to/from homes. Other factors influenced their consumption included the child’s characters, family rituals, and snack money. Values influencing snacking practices were ‘snacks as a treat or as reward’ and ‘snack is a treat, let the child make a choice’.Conclusions: Social values were significant sociocultural factors promoting childhood obesity and study of sociocultural factors are as important as economic factors and are equally needed for understanding of childhood obesity problem. This type of study help supports the design of intervention to tackle the problem.
Design and Implementation of an Intelligent Information System Based on ASP.NET MVC Technology for Rational Deployment of Medical Equipment
Authors: Zhang Haowei , You Yang , Lu Heqing 
Published: December 2020

Abstract
Background: The problem of inappropriate deployment of medical equipment in hospitals is a significant issue in China. The purpose of the information system for rational deployment of medical equipment (MERDIS) is to inform judgements about the efficient and rational deployment of medical equipment in hospitals. For research needs, the basic information of 52 hospitals in Shanghai and other provinces are investigated. The deployment method based on clinical pathway and deployment method based on big data are designed to support the data analysis of the system. Through the analysis of macro data, the rational deployment plan of medical equipment in a certain hospital is given. Result: Through the MERDIS system, it is convenient, accurate and intuitive to get the rational deployment plan and suggestions of different types of hospitals affected by different factors can be given conveniently, accurately and intuitively.Conclusion: The design of the MERDIS system provides the development basis for the subsequent development of medical equipment macro data management. In the process of continuous improvement and supplement of data, the software model will become more and more accurate and reliable.
The Design of a Novel Arthroscopy Shaver
Authors: Yuan Shiting , Xiao Shanshe , Liu Wentao , Gu Xuelian , Lai Weiguo , Chen Zhi , Liang Peng , Zhao Gaiping 
Published: December 2020

Abstract
Background: Cases of arthroscopic surgery have increased over the past two decades, and arthroscopic shaver systems have become a commonly used orthopedic tool. Nevertheless, most shavers generally have problems such as the cutting edge is not sharp enough and easy to wear. Design and validation: This paper aims to discuss the structural characteristics of BJKMC’s (Bojin◊ Kinetic Medical) novel arthroscopic shaver, the double serrated blade. The product's design and verification process are outlined. BJKMC’s articular arthroscopy shaver has a “tube in a tube” structure, comprising a stainless steel outer sleeve and a rotating hollow inner tube. The outer sleeve and inner tube have corresponding suction and cutting windows, and there are serrated teeth on the inner and outer casing. To verify the design rationality, it was compared to Dyonics◊’s equivalent product, the Incisor◊ Plus Blade. The appearance, cutting tool hardness, metal pipe roughness, cutting tool wall thickness, tooth profile, and angle, overall structure, and the key dimensions were examined and compared. Conclusion: Compared with Dyonics◊’s Incisor◊ Plus Blade, BJKMC’s Double Serrated Blade had a smoother working surface, harder and thinner blade head. Therefore, BJKMC’s product may have satisfactory performance when it comes to surgery.
Study on Deformation Characteristics and Mechanism of Q3 Loess Microstructrue Before and After Wetting&nbsp;
Authors: YIN Xiaojun , WANG Lanmin 
Published: December 2020

Abstract
Microstructure characteristics of loess is an effective way to study the physical and mechanical characteristics of soil under different conditions. Water content in sample of Q3 loess is about 25% ,which was first subjected to X-Ray test to determine the main chemical components in loess and calculated the proportion in the sample. Test analysis shows the particle structure of the loess belonged to the granular structure type. CT scanning tests were performed on the sample before and after wetting. The changes of total number of pores, the maximum pore volume and the position of the centroid of pore of the sample were analyzed before and after wetting. The results shows that the soluble salts of loess have been dissolved after wetting.The volume of the pores of loess have been changed. Some increased, some decreased and others closed in volume. The change of the number of pores indicates that the sample formed obvious saturated zone, transition zone, conduction zone and humid zones after wetting. These results reveals the deformation characteristics and mechanism of Q3 loess microstructure.
Mental Health Outcomes in Communities Exposed to Armed Conflict Experiences
Authors: Trujillo Sandra , Giraldo Luz Stella , Lopez José David , Acosta Alberto , Trujillo Natalia 
Published: December 2020

Abstract
Background: Most of the population exposed to armed conflict experiences (ACE) live in low-income countries with limited resources for social investment and mental health. Populations exposed to ACE (e.g. victims and ex-combatants) show different levels of affectation in their mental health. In this work, we aim to identify relationships between different levels of ACE and mental health outcomes.Methods: We start classifying the population in two groups: low and high exposition to ACE using the Extreme Experiences Scale (EX2). We then use a Binary Logistic Regression (BLR) and a Lineal Regression to explore the relationships between low and high levels of ACE, the empathy dimensions of the Interpersonal Reactivity Index (IRI), and the presence or absence of mental health conditions. Being ACE levels our independent variable and categories derived from Axis I diagnosis of Mini-International Neuropsychiatric Interview and dimensions of IRI scale as dependent variables. Results were obtained by calculating the Odd Ratio, Beta values, and a coefficient interval of 95%.Results: According to the cut-off points derived from the Scores of EX2 scale, the general sample were distributed in two groups: The group of high level of ACE (scores >2.5) with 119 subjects, and the low-level ACE group (scores<2.5) with 66 subjects. Our results evidence that people with high exposition to ACE experiment a higher Fantasy dimension of IRI scale and higher odds to present anxiety disorders, risk of suicide, or PTSD.Conclusion: These findings allowed us to identify the influence of ACE on mental health outcomes, to classify exposed populations, and to design effective strategies of intervention and implementation of mental health programs in these communities.
Investigation of Active Ingredients and Mechanism of Sanao Decoction in the Treatment of Chronic Cough by Network Pharmacology
Authors: Sheng Mengke , Liu Xing , Qu Qingsong , Wu Xiaowen , Liao Yuyao , Li Zhixun , Lv Lijing , Yang Jiaqi , Dai Xingxing , Shi Xinyuan 
Published: December 2020

Abstract
Background: Chronic cough significantly affects human health and quality of life. Studies have shown that Sanao Decoction（SAD）can clinically treat chronic cough. To investigate its mechanisms, we used the method of network pharmacology to conduct research at the molecular level.Methods: The active ingredients and their targets were screened by pharmacokinetics parameters from the traditional Chinese medicine system pharmacology analysis platform (TCMSP). The relevant targets of chronic cough were obtained from two databases: GeneCards and DrugBank. Take the intersection to get potential targets of SAD to treat chronic cough and establish the component-target regulatory network by CytoScape3.7.2 and protein-protein interaction (PPI) network by STRING 1.0. The function of the target gene and related pathways were analyzed by the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) in the Database for Annotation, Visualization, and Integrated Discovery (DAVID). The significant pathways and their relevant targets were obtained and the target-pathway network was established by CytoScape3.7.2. Finally, molecular docking of the core active components and relevant targets was performed.Results: A total of 98 active components, 113 targets were identified. The component-target and target-pathway network of SAD and PPI network were established. Enrichment analysis of DAVID indicated that 2062 terms were in biological processes, 77 in cellular components, 142 in molecular functions and 20 significant pathways. In addition, the molecular docking showed that quercetin and luteolin had a good combination with the corresponding targets.Conclusions: It indicates that the active compounds of SAD, such as quercetin, luteolin, may act on AKT1, MAPK1, RELA, EGFR, BCL2 and regulate PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications and Fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory, anti-airway remodeling, anti-oxidant stress and repair airway damage to treat chronic cough.
Inhalation of Nicotine-containing Electronic Cigarette Vapor Exacerbates the Features of COPD&nbsp;in βENaC-overexpressing Mice.
Authors: Ji Xiangming , Meister Maureen , Han Hongwei , Peng Guangda , Ngo Vu L. , Oluwatosin Odubade , An Junqing , Qiao Jinjuan , Song Ping , Denning Timothy Luke , Yang Jenny , Zou Ming-Hui , Liu Zhi-Ren 
Published: December 2020

Abstract
Background

Chronic obstructive pulmonary disease (COPD) is currently listed as the 3rd leading cause of death in the United States. COPD is marked by limitations in expiratory airflow, emphysematous destruction of the lungs, bronchitis, and chronic inflammation of the lung tissue. With the emerging prevalence in usage of electronic nicotine delivery systems (ENDS), the impact of ENDS on the development of lung diseases such as COPD requires further attention. Previous studies have shown that β-epithelial Na+ channel (βENaC)- overexpressing mice have multiple emphysematous phenotypes, such as mucus accumulation and chronic inflammation. This study was aimed to elucidate the effects of e-cigarettes, a type of ENDS, on the development of COPD.
Methods

We hypothesized that acute repetitive usage of ENDS will exacerbate the features of COPD including mucus production, inflammation, and fibrosis, ultimately leading to lung injury. Twenty βENaC mice (10 mice per group) underwent whole body ENDS or sham air exposure for 2 hours daily over 10 days. Bronchoalveolar lavage (BAL) fluid and lung tissues were collected to assess for inflammation, fibrosis, mucus accumulation, and alveolar damage.
Results and Discussion

Our data showed that ENDS exposure significantly increased the alveolar size as compared with the control. We also found that level of inflammatory cytokines, such as CCL2, IL-13, and IL-10, were elevated in animals exposed to ENDS compared with control. Moreover, we observed ENDS exposure caused mucus accumulation, alveolar destruction, and fibrosis in the bronchioles of the βENaC mice. Additionally, ENDS exposure promoted apoptosis in pulmonary endothelial cell and epithelial cells.
Conclusion

Our data suggest that nicotine-containing e-cigarettes exacerbates features of COPD involving abnormal lung inflammation, mucus accumulation and apoptosis in βEnaC mice.
Association Between 16S rRNA Gene Mutations and Susceptibility to Amikacin in Mycobacterium avium Complex and Mycobacterium Abscessus Clinical Isolates
Authors: Kim Su-Young , Kim Dae Hun , Moon Seong Mi , Song Ju Yeun , Huh Hee Jae , Lee Nam Yong , Shin Sung Jae , Koh Won-Jung , Jhun Byung Woo 
Published: December 2020

Abstract
We evaluated the association between 16S rRNA gene (rrs) mutations and susceptibility in amikacin-resistant nontuberculous mycobacterial (NTM) clinical isolates in NTM- pulmonary disease (PD) patients. Susceptibility was retested for 134 amikacin-resistant isolates (minimum inhibitory concentration [MIC] ≥64 µg/ml) from 86 patients. Amikacin resistance was reconfirmed in 102 NTM isolates from 62 patients with either Mycobacterium avium complex-PD (MAC-PD) (n=54) or M. abscessus-PD (n=8). MIC and rrs mutations were evaluated for 318 single colonies from these isolates. For the 54 MAC-PD patients, rrs mutations were present in all isolates (obtained from 31 patients) with an amikacin MIC ≥128 µg/ml, but only in a few isolates (from three of 23 patients) with an MIC=64 µg/ml. For the eight M. abscessus-PD patients, all amikacin-resistant isolates (MIC ≥64 µg/ml) had rrs mutations. Of amikacin resistance isolates, A1408G mutation (n=29) was most common. Two novel mutations, C1496T and T1498A, were also identified. The culture conversion rate did not differ by amikacin MIC (20% for MIC=64µg/ml vs. 7% for MIC ≥128 µg/ml, p=0.468). In conclusion, all amikacin-resistant M. abscessus isolates had rrs mutations, but in MAC isolates showing relatively low resistance (MIC=64µg/ml), rrs mutations were infrequently identified.
Top 100 Cited Systematic Reviews and Meta-Analyses in The Major Journals of Oral and Maxillofacial Surgery: A Bibliometric Analysis
Authors: Al-Moraissi Essam , Galvão Endi Lanza , Christidis Nikolaos , Falci Saulo Gabriel 
Published: December 2020

Abstract
Background : The aim of this bibliometric research was to identify and analyze the top 100 cited systematic reviews in the field of oral and maxillofacial surgery. Methods : Using the Web of Science-database without restrictions on publication year or language, a bibliometric analysis was performed for the five major journals of oral and maxillofacial surgery: International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, Journal of Cranio-maxillofacial Surgery, British Journal of Oral & Maxillofacial Surgery and Oral Surgery Oral medicine Oral pathology Oral radiology. Discussion : The most top-cited systematic review was published in 2015 with a total of 200 citations on survival and success rates of dental implants, consistent with the finding that “pre- and peri-implant surgery and dental implantology”, and “craniomaxillofacial deformities and cosmetic surgery” were the most frequently-cited topics (22% each). The International Journal of Oral and Maxillofacial Surgery displayed both most citations in total and in average per publication. The outcome of this article can be used as a source of information not just for researchers but also for clinicians and students, and of which areas have a large impact on the field of oral and maxillofacial surgery but cannot reflect the quality of the included systematic reviews.Systematic review registration: not applicable
miR-378a-5p inhibits the proliferation of colorectal cancer cells by downregulating CDK1
Authors: Li Kai , zhang Jieling , Zhang Mingkang , Wu Yaohua , Lu xinyu , zhu Yiping 
Published: December 2020

Abstract
Background
MicroRNAs (miRNAs) exerts a vital part in tumor occurrence.The role of miR-378a-5p and CDK1 in colorectal cancer (CRC) was investigated in this study.
Methods
The investigation of TCGA database and the detection of miR-378a-5p expression in colorectal cancer pathological tissues and colorectal cancer cell lines were performed by using qRT-PCR. We conducted cell function experiments (CCK-8, EDU, Colony formation assay, Wound healing assay, Transwell assay, Cell apoptosis detection, Cell cycle detection) and nude mouse tumor formation experiments to evaluate the effects of miR-378a-5p on proliferation, metastasis, The impact of invasion to explore the role of miR-378a-5p in vivo and in vitro. Then, through the TCGA database, immunohistochemistry of pathological tissues, and cell function experiments, the role of the target gene CDK1 of miR-378a-5p verified by database prediction and dual luciferase reporter gene experiments in colorectal cancer was explored. Finally, whether up-regulation of CDK1 restores the inhibitory effect of overexpression of miR-378a-5p on the proliferation of CRC cells is studied by overexpression of CDK1.
Results
Bioinformatics analysis showed significant downregulation of miR-378a-5p level within colorectal cancer (CRC). Cell function experiments and tumor xenograft mouse models confirmed the low expression of miR-378a-5p within CRC tissues, which indicated the tumor suppression role of miR-378a-5p within CRC. For better exploring the regulation of miR-378a-5p in CRC, we predicted and validated cell cycle-dependent protein kinase 1 (CDK1) to be the miR-378a-5p target geneand found that miR-378a-5p suppressed CRC cell proliferation by targeting CDK1.
Conclusion
To sum up, results in this work discover the mechanism of miR-378a-5p in retarding CRC cell proliferation through suppressing CDK1 expression, and it may become a possible therapeutic target to treat CRC.
Patient Reported Physical and Mental Health Changes Associated with a Comprehensive Cardiovascular Risk Reduction Program for Women with Breast Cancer Receiving Potentially Cardiotoxic Chemotherapy
Authors: Fradley Michael , Alomar Mohammed , Kilpatrick Marcus W. , Shields Bernadette , Tran Nhi , Best Amey , Bianco Erika , Armanious Merna , Vautier R. Ashton , Kip Kevin , Beckie Theresa , Ismail-Khan Roohi 
Published: December 2020

Abstract
Objective: Women with breast cancer (BCA) and cardiovascular disease (CVD) risk factors are at increased risk of developing cardiovascular complications when exposed to potentially cardiotoxic cancer therapy. The benefit of aggressive CVD risk factor modification to reduce adverse treatment-related psychologic and biologic effects is not well established.Methods: Using a single group pre-test, post-test design, 33 women with BCA receiving anthracycline and/or trastuzumab therapy participated in a 6-month comprehensive CVD risk reduction program involving formal cardio-oncology evaluation along with regular motivational counseling for improved nutrition and physical activity. Study parameters were assessed at baseline and 6 months with paired t-tests used to evaluate changes after the intervention.Results: The mental component summary score assessed by SF-36V2 improved significantly after program completion (45.0 to 48.8, effect size 0.37, p=0.017), however the physical component summary score declined (46.2 to 40.9, effect size -0.53, p=0.004). Despite this decline in perceived physical health, markers of health-related fitness and nutritional status were maintained or improved. Systolic and diastolic blood pressure also improved after the intervention (136.7 to 124.1 mm Hg, p=0.001 and 84.0 to 78.7 mm Hg, p=0.031, respectively). No significant change in resting heart rate, body mass index, lipids, hemoglobin A1C, or left ventricular ejection fraction was observed. Conclusions: Patient-reported mental health improved significantly in women with BCA enrolled in a comprehensive CVD risk reduction program despite exposure to potentially cardiotoxic therapies. This study provides preliminary data for future randomized controlled trials evaluating the effects CVD risk reduction program in high-risk breast cancer cohorts.
Diagnostic Biomarkers in Cerebrospinal Fluid in Primary Central Nervous System Lymphoma: A Protocol for Systematic Review and Meta-Analysis
Authors: Zhou Lili , Yi Hai , Chen Dan , Zhang Qian , Fan Fangyi , Qiu Ling , Zhang Nan , Su Yi 
Published: December 2020

Abstract
BackgroundPrimary central nervous system lymphoma (PCNSL) is a highly aggressive non-hodgkin’s lymphoma with unfavorable prognosis. Currently, the diagnosis of PCNSL relies on brain excisional biopsy, which is an invasive procedure, carries the risk of complications such as intracranial hemorrhage and functional impairment. Finding effective biomarkers will help us to diagnose PCNSL faster and safer.MethodsThis systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) 2015 guideline.We will search databases including PubMed, Cochrane Library, Medline, Web of Science, EMBASE and CNKI. The studies that demonstrated the diagnostic value of certain biomarkers in CSF for PCNSL will be included. For quantitative value, the standardized mean diffenence (SMD) and their 95% confidence intervals (CI) will be calculated. The outcomes are the mean difference of biomarker levels in CSF between PCNSL patients and controls.DiscussionIn this systematic review we will analyze the studies of the biomarkers in cerebrospinal fluid for diagnosis of PCNSL. This research can help us to identify the biomarkers with diagnostic value for PCNSL, making diagnosis of PCNSL easier, faster and safer.Systematic review registrationPROSPERO CRD42020218143.