bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
Authors:   The Glioma International Case-Control Study (GICC), Zhang Chenan , Ostrom Quinn T. , Semmes Eleanor C. , Ramaswamy Vijay , Hansen Helen M. , Morimoto Libby , de Smith Adam J. , Pekmezci Melike , Vaksman Zalman , Hakonarson Hakon , Diskin Sharon J. , Metayer Catherine , Taylor Michael D. , Wiemels Joseph L. , Bondy Melissa L. , Walsh Kyle M. 
Published: October 2020

Abstract
Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymoma risk, we utilized case–control data from three studies: a population-based pediatric and adolescent ependymoma case–control sample from California (153 cases, 696 controls), a hospital-based pediatric posterior fossa type A (EPN-PF-A) ependymoma case–control study from Toronto’s Hospital for Sick Children and the Children’s Hospital of Philadelphia (83 cases, 332 controls), and a multicenter adult-onset ependymoma case–control dataset nested within the Glioma International Case-Control Consortium (GICC) (103 cases, 3287 controls). In the California case–control sample, a polygenic score for longer telomere length was significantly associated with increased risk of ependymoma diagnosed at ages 12–19 (P = 4.0 × 10−3), but not with ependymoma in children under 12 years of age (P = 0.94). Mendelian randomization supported this observation, identifying a significant association between genetic predisposition to longer telomere length and increased risk of adolescent-onset ependymoma (ORPRS = 1.67; 95% CI 1.18–2.37; P = 3.97 × 10−3) and adult-onset ependymoma (PMR-Egger = 0.042), but not with risk of ependymoma diagnosed before age 12 (OR = 1.12; 95% CI 0.94–1.34; P = 0.21), nor with EPN-PF-A (PMR-Egger = 0.59). These findings complement emerging literature suggesting that augmented telomere maintenance is important in ependymoma pathogenesis and progression, and that longer telomere length is a risk factor for diverse nervous system malignancies.
Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study
Authors: Viña-Almunia Jose , Pellicer-Chover Hilario , García-Mira Berta , Romero-Millán Javier , Peñarrocha-Oltra David , Peñarrocha-Diago Miguel 
Published: October 2020

Abstract

Objective
The objective of the study was to evaluate the relation between occlusal loading and peri-implant crevicular fluid cytokine expression in patients with implant-supported complete fixed prostheses in both arches.

Material and methods
A prospective longitudinal clinical study was performed at a university clinic. Fifteen patients were selected and 11 were included. All patients had bimaxillary implant-supported complete fixed ceramo-metallic prostheses loaded at least 12 months before the beginning of the study. Allocation was established for each patient using a computerized occlusal analysis system. The test implant was the maxillary implant closest to the point of highest occlusal loading. The maxillary implant with least loading was the control implant. Occlusal adjustment was performed using a round diamond burr. This occlusal distribution was verified with the occlusal analysis system. Expression of cytokines from peri-implant crevicular fluid (TNF-α, IL-10, IL-6, IL-1β, IL-8) were recorded and analyzed in both test and control implants before (baseline: T0) and 2 (T1) and 12 months (T2) after occlusal adjustment. The Brunner-Langer non-parametric test was performed.

Results
At T0, the expression of IL-10 was significantly higher in the test group implants (p = 0.018). Between T0 and T1, the expression of all the cytokines decreased in the implants of both groups with statistically significant differences, except for TNF (p = 0.271). When comparing both groups at T1, there was no statistically significant difference in any of the analyzed cytokines. At T2, TNF-α suffered when compared with baseline, a statistical decrease in both study and control implants (p < 0,001). At T2, there were no statistically significant differences between groups in any of the cytokines analyzed.

Conclusions
Implants with higher occlusal load presented higher expression of IL-10 in peri-implant crevicular fluid. Occlusal adjustment produced a decrease in the expression of all the analyzed cytokines, both in test and control implants.
Contact dermatitis associated with the Bispectral index™ sensor: a case report
Authors: Taguchi Noriko , Taguchi Shijima , Ishizuki Syoichiro , Ito Hiroyuki 
Published: October 2020

Abstract

Background
Contact dermatitis caused by electroencephalography electrodes is rare and insufficiently studied. We described a case of contact dermatitis caused by Bispectral Index (BIS) monitor electrodes.

Case presentation
A 38-year-old woman underwent tooth extraction under general anesthesia with BIS monitoring. She noticed erythema on her forehead 3 days after surgery, which peaked on the fifth postoperative day. Slight pigmentation was observed at 42 days after surgery. We performed patch testing and confirmed positive reactions to the sensor and some allergens.

Conclusions
Many reports have attributed contact dermatitis to an allergen present in electrocardiogram electrodes. It is important to recognize that complications similar to those caused by electrocardiogram electrodes can occur with this sensor.
Resemblance and clustering of mother’s and father’s psychopathology levels among Chinese parents of schoolchildren with psychiatric disorders
Authors: Gao Yuan , Liu Yunyong , Wang Ping , An Xiaoxia , Xu Shaohe , Yu Fei , Chen Qian , Li Yuying , Wang Shuangling , Lv Jianda , Pan Guowei , Wang Ping 
Published: October 2020

Abstract

Background
Few studies have assessed the characteristics of spousal psychopathologies among parents of schoolchildren with and without psychological disorders (PD) in China.

Methods
Parental symptoms were measured using the General Health Questionnaire (GHQ) in 275 mothers and 278 fathers of 298 schoolchildren with PDs diagnosed in a population survey and in 825 mothers and 834 fathers of 894 schoolchildren without PDs as a 1:3 matched comparison group. Spousal GHQ scores were compared. Childhood PD type, presence of childhood comorbidities, and multiple parental and family characteristics were examined as predictors for parental GHQ scores by multiple linear regression analyses.

Results
The GHQ scores were significantly higher among mothers and fathers of children with any PD. Maternal GHQ scores were higher than paternal scores and significantly correlated with paternal GHQ scores in both groups. Spousal GHQ, personal PD history, and childhood PD comorbidity were significant independent predictors of both parents’ GHQ scores. There were also significant associations among parental chronic disease, low family income, and paternal and maternal GHQ score, as well as among low maternal education, less common disorder (LCD) prevalence in children and maternal GHQ score. The rate of GHQ score ≥3 for both parents was significantly higher in the study group than the control group (15.1 vs.7.0%).

Conclusions
Parents of children with any PD type demonstrate significantly elevated psychopathologies, and psychopathology tends to occur concomitantly and resemble that of the other spouse. Screening and treatment of parental psychiatric symptoms will benefit all family members.
Clinical Utility and User Perceptions of a Digital System for Electronic Patient-Reported Symptom Monitoring During Routine Cancer Care: Findings From the PRO-TECT Trial
Authors: Basch Ethan , Stover Angela M. , Schrag Deborah , Chung Arlene , Jansen Jennifer , Henson Sydney , Carr Philip , Ginos Brenda , Deal Allison , Spears Patricia A. , Jonsson Mattias , Bennett Antonia V. , Mody Gita , Thanarajasingam Gita , Rogak Lauren J. , Reeve Bryce B. , Snyder Claire , Kottschade Lisa A. , Charlot Marjory , Weiss Anna , Bruner Deborah , Dueck Amylou C. 
Published: October 2020

PURPOSE There is increasing interest in implementing digital systems for remote monitoring of patients’ symptoms during routine oncology practice. Information is limited about the clinical utility and user perceptions of these systems. METHODS PRO-TECT is a multicenter trial evaluating implementation of electronic patient-reported outcomes (ePROs) among adults with advanced and metastatic cancers receiving treatment at US community oncology practices (ClinicalTrials.gov identifier: NCT03249090 ). Questions derived from the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) are administered weekly by web or automated telephone system, with alerts to nurses for severe or worsening symptoms. To elicit user feedback, surveys were administered to participating patients and clinicians. RESULTS Among 496 patients across 26 practices, the majority found the system and questions easy to understand (95%), easy to use (93%), and relevant to their care (91%). Most patients reported that PRO information was used by their clinicians for care (70%), improved discussions with clinicians (73%), made them feel more in control of their own care (77%), and would recommend the system to other patients (89%). Scores for most patient feedback questions were significantly positively correlated with weekly PRO completion rates in both univariate and multivariable analyses. Among 57 nurses, most reported that PRO information was helpful for clinical documentation (79%), increased efficiency of patient discussions (84%), and was useful for patient care (75%). Among 39 oncologists, most found PRO information useful (91%), with 65% using PROs to guide patient discussions sometimes or often and 65% using PROs to make treatment decisions sometimes or often. CONCLUSION These findings support the clinical utility and value of implementing digital systems for monitoring PROs, including the PRO-CTCAE, in routine cancer care.
Long-Term Toxicity and Efficacy of Intensity-Modulated Radiation Therapy in Cervical Cancers: Experience of a Cancer Hospital in Pakistan
Authors: Mansha Muhammad Atif , Sadaf Tabinda , Waheed Asmara , Munawar Amna , Rashid Asma , Chaudry Samreen Javed 
Published: October 2020

PURPOSE To report the chronic toxicity and disease outcomes attributable to intensity-modulated radiation therapy (IMRT) in patients with cervical cancer. METHODS AND MATERIALS Between January 2014 and December 2018, a retrospective review of medical records of patients with cervical cancer who received radiation therapy with IMRT was performed. Disease and treatment-related details were documented. Follow-up notes were reviewed, and severity of late toxicities was recorded. Overall survival (OS) and disease-free survival (DFS) at 3 years were estimated. RESULTS A total of 222 patients’ records were reviewed. Mean age was 50.7 years. Median follow-up duration was 33 months (range, 2-70 months). The most common toxicity was vaginal stricture (grade 2, n = 59, 26.6%; grade 3, n = 4, 1.80%), followed by proctitis (grade 2, n = 24; 10.8%; grade 3, n = 7; 3.20%). Seven patients (grade 2, n = 5, 2.3%; grade 3, n = 2; 0.90%) developed cystitis, and only 5 (grade 2; 2.3%) were found to have colitis. None of the patients had grade 4 or grade 5 toxicities. There was a significant difference in late complications in patients with nodal disease or those who underwent prior surgery ( P < .05). Three-year OS and DFS rates were 79.7% and 81.9%, respectively. Patients with tumor size > 5 cm and those with pelvic lymph node metastasis had poor survival rates ( P < .05). CONCLUSION IMRT is an effective and well-tolerated technique that should be considered in patients with lymph node disease and in postoperative patients. There is an inverse relationship between tumor size and nodal involvement with respect to OS and DFS.
Prospective Multicenter Study of Circulating Tumor Cell AR-V7 and Taxane Versus Hormonal Treatment Outcomes in Metastatic Castration-Resistant Prostate Cancer
Authors: Armstrong Andrew J. , Luo Jun , Nanus David M. , Giannakakou Paraskevi , Szmulewitz Russell Z. , Danila Daniel C. , Healy Patrick , Anand Monika , Berry William R. , Zhang Tian , Harrison Michael R. , Lu Changxue , Chen Yan , Galletti Giuseppe , Schonhoft Joseph D. , Scher Howard I. , Wenstrup Richard , Tagawa Scott T. , Antonarakis Emmanuel S. , George Daniel J. , Halabi Susan 
Published: October 2020

PURPOSE Androgen receptor splice variant 7 (AR-V7) detection in circulating tumor cells (CTCs) is associated with a low probability of response and short progression-free (PFS) and overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide or abiraterone. However, it is unclear whether such men benefit from taxane chemotherapy. PATIENTS AND METHODS PROPHECY is a multicenter prospective blinded study of patients with poor-risk mCRPC starting abiraterone or enzalutamide and observed through subsequent progression and taxane chemotherapy. We assessed AR-V7 status using the Johns Hopkins modified AdnaTest CTC AR-V7 messenger RNA assay and the Epic Sciences CTC nuclear-localized AR-V7 protein assay before treatment. The primary objective was to validate the independent prognostic value of CTC AR-V7 status based on radiographic/clinical PFS. OS, confirmed prostate-specific antigen (PSA), and objective radiologic responses were secondary end points. RESULTS We enrolled 118 men with mCRPC treated with abiraterone or enzalutamide, 51 of whom received subsequent docetaxel or cabazitaxel. Pretreatment CTC AR-V7 status by the Johns Hopkins and Epic Sciences assays was independently associated with worse PFS (hazard ratio [HR], 1.7; 95% CI, 1.0 to 2.9 and HR, 2.1; 95% CI, 1.0 to 4.4, respectively) and OS (HR, 3.3; 95% CI, 1.7 to 6.3 and HR, 3.0; 95% CI, 1.4 to 6.3, respectively) and a low probability of confirmed PSA responses, ranging from 0% to 11%, during treatment with abiraterone or enzalutamide. At progression, subsequent CTC AR-V7 detection was not associated with an inferior PSA or radiographic response or worse PFS or OS with subsequent taxane chemotherapy after adjusting for CellSearch CTC enumeration and clinical prognostic factors. CONCLUSION Detection of AR-V7 in CTCs by two different blood-based assays is independently associated with shorter PFS and OS with abiraterone or enzalutamide, but such men with AR-V7–positive disease still experience clinical benefits from taxane chemotherapy.
Differentiation of ciliated human midbrain-derived LUHMES neurons
Authors: Lauter Gilbert , Coschiera Andrea , Yoshihara Masahito , Sugiaman-Trapman Debora , Ezer Sini , Sethurathinam Shalini , Katayama Shintaro , Kere Juha , Swoboda Peter 
Published: October 2020

ABSTRACT
Many human cell types are ciliated, including neural progenitors and differentiated neurons. Ciliopathies are characterized by defective cilia and comprise various disease states, including brain phenotypes, where the underlying biological pathways are largely unknown. Our understanding of neuronal cilia is rudimentary, and an easy-to-maintain, ciliated human neuronal cell model is absent. The Lund human mesencephalic (LUHMES) cell line is a ciliated neuronal cell line derived from human fetal mesencephalon. LUHMES cells can easily be maintained and differentiated into mature, functional neurons within one week. They have a single primary cilium as proliferating progenitor cells and as postmitotic, differentiating neurons. These developmental stages are completely separable within one day of culture condition change. The sonic hedgehog (SHH) signaling pathway is active in differentiating LUHMES neurons. RNA-sequencing timecourse analyses reveal molecular pathways and gene-regulatory networks critical for ciliogenesis and axon outgrowth at the interface between progenitor cell proliferation, polarization and neuronal differentiation. Gene expression dynamics of cultured LUHMES neurons faithfully mimic the corresponding in vivo dynamics of human fetal midbrain. In LUHMES cells, neuronal cilia biology can be investigated from proliferation through differentiation to mature neurons.
TAPAS: Towards Automated Processing and Analysis of multi-dimensional bioimage data
Authors: Gilles Jean-François , Boudier Thomas 
Published: October 2020

Modern microscopy is based on reproducible quantitative analysis, image data should be batch-processed by a standardized system that can be shared and easily reused by others. Furthermore such system should require none or minimal programming from the users. We developed TAPAS (Towards an Automated Processing and Analysis System). The goal is to design an easy system for describing and exchanging processing workflows. The protocols are simple text files comprising a linear list of commands used to process and analyse the images. An extensive set of 60 modules is already available, mostly based on the tools proposed in the 3D ImageJ Suite. We propose a wizard, called TAPAS menu, to help the user design her protocol by listing the available modules and the parameters associated. Most modules will have default parameters values for most common tasks. Once the user has designed her protocol, she can apply the protocol to a set of images, that can be either stored locally or on a OMERO database. An extensive documentation including the list of modules, various tutorials and link to the source code is available at https://imagej.net/TAPAS.
Automatische Wiedererkennung von individuellen Objekten mit dem Dynamic Anchoring Agent
Authors: Günther Martin , Kammler Friedemann , Ferdinand Oliver , Hertzberg Joachim , Thomas Oliver , Zielinski Oliver 
Published: October 2020

ZusammenfassungIndividuelle Objekte spielen im Alltag eine zentrale Rolle und machen deren Unterscheidung zu einer wichtigen Voraussetzung für den Einsatz von Robotik. Die Herausforderung liegt dabei nicht allein in der sensorischen Wahrnehmung, sondern auch in der Verknüpfung mit vorhandenem Wissen: So können zwei für Verfahren der Objekterkennung identische Gegenstände durch ihre Funktion („Der Akkuschrauber, den ich zuletzt genutzt habe“) oder ihren Umgebungskontext („Die Tasse auf meinem Tisch“) eine eindeutige Zuordnung erhalten. Die Robotik adressiert diese Herausforderung unter dem Begriff des Anchorings, also der Fähigkeit, individuelle Objekte eindeutig zu erkennen und anhand ihres Kontexts wiederzuerkennen, sobald sie einmal aus dem Wahrnehmungsbereich gelangt sind. Auf technischer Ebene besteht dabei das Problem, Beziehungen zwischen Sensordaten und Symbolen in einer Wissensbasis herzustellen und so physische Objekte konkret zu adressieren. Der Beitrag stellt das Anchoring-Problem sowie den Dynamic Anchoring Agent (DAA) als einen Lösungsansatz vor. Anhand von zwei realen Anwendungsszenarien wird der Einsatz des DAA demonstriert: Anhand eines MakerSpaces werden die Möglichkeiten zur erweiterten Kooperation zwischen Menschen und Robotern gezeigt - beispielsweise durch die Suche und Identifikation von persönlichem Werkzeug oder benötigten Produktionsmaterialien. Eine zweite Anwendung verdeutlicht am Beispiel eines Yachthafens den weiterführenden Einsatz in dynamischen Umgebungen.
¿Un pensador utópico muere de hambre?
Authors: Palazón Mayoral María Rosa 
Published: October 2020

Resumen: Para José Joaquín Fernández de Lizardi los avances del liberalismo simularon fines nacionalistas; pero los enterraron, porque el medio peso diario que le asignó el presidente Victoria se lo robaron, mentirosos todos, enemigos furibundos de un estado de bienestar generalizado en los obrajes, las escuelas y la familia. Lizardi murió de hambre. Pasó de la oralidad a la escritura. Según él “hizo lo que pudo por su patria”; pero fue corrupta. El Pensador no calló las injusticias que enterraron las victorias de los revolucionarios. Primer novelista; primer autor único de periódico, donde se denuncian cómo se torcieron las utopías. Hace más en pro de México desde que falleció; dejó sus “papeles” de excomulgado. Pasó parte de su existencia en prisión.
Palabras clave: Utopía, patria, nación, independencia, analfabetos.
Discriminación y violencia
Authors: Spathi Aglaía 
Published: October 2020

En la narrativa de Rosario Castellanos encontramos conflictos raciales que caracterizan el ambiente de la provincia del México en la época postrevolucionaria y determinan la forma de vida socioeconómica de los individuos. En “Vals capricho”, la protagonista conoce en carne propia la marginación social solo por llevar la sangre india. Así que ella nunca será aceptada por una sociedad implacable que la conducirá a la locura y la amarga soledad. Por otra parte, Onelio Jorge Cardoso, a través de sus cuentos presenta a personajes que viven en condiciones de exclusión y discriminación y sufren las consecuencias de la crisis política, social y moral de Cuba, debido a las estructuras sociales de su época que siembran en el individuo miedos y prejuicios. Específicamente en “Teresa”, una mujer de las capas bajas, siente vergüenza de su origen, por eso, trata con actitud racista a dos personas de color, considerándolas inferiores cultural y mentalmente, sometiéndolas a la marginación y privándolas de la plenitud. El objetivo de este trabajo es a través de un estudio histórico-cultural destacar motivos predominantes como la violencia y la discriminación social entre otros latentes en los cuentos anteriormente mencionados.
Políticas y reformas en etnoeducación afrocaribe colombiano
Authors: Múnera Cavadías Liris , Lago de Vergara Diana , Lago de Fernández Carmen Cecilia 
Published: October 2020

El Grupo de Investigación RUECA de la Universidad de Cartagena, liderado por la Dra. Diana Lago de Vergara, desde el proyecto de Maestras Afrodescendientes e Indígenas en el Caribe Colombiano y su semillero de investigación “La Universidad va a la Escuela”, participante en el Macroproyecto de Historias de Vida de Maestras Rurales, Indígenas, Africanas y Afrodescendientes, que lidera la Dra. Diana Soto del grupo HISULA, ha realizado investigación cualitativa y ha continuado revisando documentos que han enriquecido el estudio sobre los desafíos y nuevas perspectivas en la etnoeducación Afro, en el caribe colombiano, caso Cartagena de Indias.
Este artículo da cuenta de resultados consolidados de investigaciones y experiencia vivencial, como visita al palenque de San Basilio, asentamiento de esclavos libertos, donde se realizó una experiencia pedagógica en escuelas, miembros de la comunidad sobre la cultura, interacciones sociales, cosmovisión, entre otros tópicos, igualmente se realizaron visitas a instituciones etnoeducativas de Cartagena de Indias, donde muchos de sus estudiantes proceden del palenque de San Basilio y de otros palenques, complementando la información primaria con revisión documental sobre políticas y normas vigentes.