bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of allithiamine on the level of hyperglycaemia-induced advanced glycation end products
Authors: Bíró Attila , Remenyik Judit 
Published: December 2019

Diabetes mellitus is a rapidly growing public health burden in both developed and developing countries. Diabetes mellitus is accompanied by hyperglycaemia, which can cause tissue injury by several mechanisms. One of these is the formation of advanced glycation end-products (AGEs). In this study, the effect of allithaimine, a fat-soluble thiamine derivative, was investigated on hyperglycaemia-induced AGEs levels using human umbilical cord vein endothelial cells (HUVECs) as a hyperglycaemic model. HUVECs were isolated by enzymatic digestion, characterized by flow cytometer and treated 30 mM glucose plus allithaimine or thiamine or cell maintenance medium as control. Allithiamine was synthesized and purified. The structure of the synthesized and isolated compound was verified by reverse phase HPLC and MALDI-TOF. AGEs were evaluated by ELISA. Collectively, our results indicate that allithiamine can reduce level of the hyperglycaemia-induced AGEs similar to thiamine.
The effect of fertilization and plant protection in sunflower (Helianthus annuus L.) production
Authors: Futó Zoltán 
Published: December 2019

Sunflower is the most important oil crop in Europe which is grown on the biggest area of all the oil crops. The area of producing sunflowers in Hungary was changing to 524–704 thousand hectares in the past decade in comparison with approximately 100 thousand hectares in the 1970’s. In our experiment different sunflower hybrids were examined. The doses of fertilizers were the following in 2017 and 2018: 0–30–90–150 kg ha-1 N, 0-50-90-90 kg ha-1 P2O5 and 0–70–110–110 kg ha-1 K2O. Three different treatments of plant protection were used in the experiment to protect them from fungal infections. A rise in the dosage of nitrogen resulted in increasing infection. The biggest fungal infection was identified in 150 kg ha-1 N, 90 kg ha-1 P2O5 and 110 kg ha-1 K2O treatment. The largest infection was measured on plots without plant protection at the highest N doses, both in leaf and disc diseases. We measured the highest 41.25% in 2017 and 53.1% in 2018 Diaporthe helianthi infection, and 24.5% in 2017 and 25.5 % in 2018 Sclerotinia sclerotiorum disc infection in these plots. kg ha-1
Average yield was changing between 2.96–4.67 t ha-1 in 2017/2018. The lowest yield was obtained in the absolute control plot (without plant protection and without nutrient) in both years, which was 2.96 t ha-1 in 2017 and 3.14 t ha-1. The yields increased due to growing nutrient supply and excellent plant protection. The highest yields were 3.67 t ha-1 in 2017 and 4.67 t ha-1 in 2018 (150 kg ha-1 N, 90 kg ha-1 P2O5 and 110 kg K2O active substance). Purpose of the experiment at analysing the impact of different treatments on the profitability of sunflower production.
Territorialidade e mobilidade: o Nikkei como profissional liberal médico / Territoriality and mobility: Nikkei as a medical liberal professional
Authors: De Sousa Adriano Amaro 
Published: December 2019

O presente artigo procurou compreender a territorialidade e a mobilidade dos profissionais liberais nikkeis médicos no município de Presidente Prudente/SP. Para tanto, os aspectos metodológicos estão balizados pelos depoimentos orais dos nikkeis descritos na literatura especializada da ciência geográfica. Todavia, na primeira parte do artigo, iremos tratar do conceito de territorialidade articulado com as relações de sociabilidade dos japoneses e seus descendentes no Brasil, visando compreender a mobilidade das famílias nipônicas. Já na segunda parte, buscaremos traçar o percurso da mobilidade espacial e social dos nikkeis profissionais liberais médicos, tendo como estudo de caso a trajetória (vida, estudos e profissão) de três médicos: o dr. Sizuvo Iamada, o dr. Tadashi Uchida e o dr. Neiw Iamada. Assim, o dr. Sizuvo Iamada não era originário de Presidente Prudente/SP, mas escolheu essa cidade para empreender, trabalhar e morar. Porém, no caso dos doutores Tadashi Uchida e Neiw Iamada ambos têm Presidente Prudente/SP como lugar de origem e são filhos da classe média/alta local, terminaram a faculdade/residência e, paulatinamente, retornaram ao município natal como médicos para assumir os negócios da família.Palavras-chave: territorialidade, mobilidade, família, nikkei e Presidente Prudente/SP.
A decadência ideológica burguesa e suas nuances: reflexões e apontamentos da destruição e da miséria da razão na ciência geográfica / The bourgeois ideological decadence and their nuances: reflections and notes of the destruction and the misery of the reason of reason in geographical science
Authors: Queiroz William Fernando Camilo 
Published: December 2019

Este artigo pretende fazer uma discussão acerca da Geografia e suas tendências estruturalistas e, sugerir a designação dessas correntes, na expressão, “Miséria da Razão”, teoria que foi formulada e elaborada por Carlos Nelson Coutinho, (1972), com base em, Gyorgy Lukács, (1958), na obra, “Destruição da Razão”, para assinalar a introdução, e, a, aceitação, do irracionalismo na Geografia. Assim, objetiva analisar, o empobrecimento agnóstico das categorias racionais na contemporaneidade, expressão do pensamento ideológico da burguesia em sua decadência e contra revolução, como também, suas afiliações, e, por fim, mostrar a incapacidade dentro de correntes do pensamento contemporâneo, de aceitar a razão dialética, a dimensão histórica, e, o humanismo. É resultado de leituras forjada na disciplina, Metodologia Científica em Geografia: Método, Teoria e o Pensamento Geográfico, na FCT Unesp, campus de Presidente Prudente
Caracterização e uso da paisagem de São Domingos- GO para atividade turística: uma alternativa frente ao avanço da monocultura Characterization and use of the landscape of São Domingos-GO / For tourism activity: an alternative in the advance of monoculture advancement
Authors: Aguiar Junior Paulo Roberto Ferreira de , De Oliveira Ivanilton Jose , Barros Juliana Ramalho 
Published: December 2019

Este artigo tem como objetivo apresentar a caracterização físico-natural do município de São Domingos, localizado no estado de Goiás e assim fornecer subsídios necessários para que o município seja polo de desenvolvimento da atividade turística ligada a natureza e por conseguinte uma alternativa para geração de renda. O trabalho foi realizado devido a região possuir uma beleza cênica ímpar e que sobre pressão dos agricultores em razão de haver, em grande parte de sua área, latossolos, que são solos profundos, porosos, bem drenados, bem permeáveis, friáveis e de fácil preparo que com as devidas correções química seu uso para a agricultura se torna perfeito. A atividade intensiva desenvolvida nessas áreas é prejudicial não somente do ponto de vista natural, como do ponto de vista econômico, visto que as propriedades pertencem a grandes latifundiários. Frente a esse cenário, o turismo pode ser uma alternativa para a proteção dos recursos naturais e também para o crescimento econômico.
As contribuições das tecnologias assistivas para a promoção da inclusão escolar
Authors: Mota Maria Kalionara de Freitas 
Published: December 2019

Resumo: Este trabalho busca, baseado em estudos de autores como Bersch (2010), Capovilla (1997), Amaral (1994), entre outros, pesquisar como utilizar as diversas tecnologias assistivas para promover a educação inclusiva de alunos com necessidades educacionais especiais. Para empreender tal estudo fez-se necessária uma revisão bibliográfica explicitando o que é tecnologia assistiva, como também, uma apresentação das categorias de tecnologia assistiva, enfatizando como essas podem ser utilizadas como recursos de acessibilidade na educação. Também foi ressaltada a regulamentação da educação inclusiva e a importância do apoio da família para o ensino inclusivo. Optou-se por utilizar a pesquisa-ação como procedimento metodológico por acreditar que esse tipo de pesquisa permite desenvolver uma investigação que aponte a transformação de uma realidade, como também implica diretamente na participação dos agentes envolvidos no processo ensino/aprendizagem. Constatou-se que as tecnologias assistivas vêm sendo usadas para aumentar, manter ou melhorar as habilidades das pessoas com necessidades especiais, promovendo a independência dessas pessoas na área educacional, como também nas rotinas diárias e ainda promovem a inclusão e a participação no meio social em que estão inseridas.
Palavras-chave:Inclusão. Necessidades Educacionais Especiais. Tecnologias Assistivas.
Educação em contexto de cultura digital: potências pedagógicas e possibilidades de visibilidade para o conhecimento científico escolar
Authors: Domingues Ramos Luciana , Boll Cíntia Inês 
Published: December 2019

Resumo: O artigo tem por objetivo apresentar considerações relacionadas à cultura digital, seus desafios e possibilidades na Educação. O recorte principal desta produção é o potencial pedagógico de um trabalho apoiado pelas mídias, pelas linguagens e convergências digitais em direção à construção do conhecimento na perspectiva ética-estética dessa relação. O tensionamento é provocado com contribuições de autores como Pierre Lévy, Massimo Canevacci, Henry Jenkins, Martha Marandino, Myriam Krasilchik, entre outros estudiosos desse mundo da educação, comunicação e cultura digital. O trabalho conclui que o contexto amplificado e convergente da cultura digital pode ser visto sob uma perspectiva que o entenda como um aliado da escola, não somente no acesso à informação e ao conhecimento, mas um mobilizador de propostas participativas de educação, em oposição a uma educação bancária, que ressignifica as relações, visibiliza as construções da escola, o conhecimento científico escolar e viabiliza a formação de um sujeito autor, colaborador, comunicador, ético e cidadão também em contexto digital.
Palavras-chave: Educação. Ensino de Ciências. Cultura da convergência.
GAMBARAN IMT/U, ASUPAN ZAT BESI (FE), DAN INHIBITOR ZAT BESI (FE) DENGAN ANEMIA REMAJA PUTRI DI SMA MUHAMMADIYAH 7 SAWANGAN, DEPOK TAHUN 2018
Authors: Damanik Agrina Herliana , Simanungkalit Sintha Fransiske , Arini Firlia Ayu 
Published: December 2019

Latar belakang : anemia adalah keadaan yang ditandai dengan berkurangnya hemoglobin dalam tubuh. Hemoglobin adalah suatu metaloprotein yaitu protein yang mengandung zat besi di dalam sel darah merah yang berfungsi sebagai pengangkut oksigen dari paru-paru ke seluruh tubuh. Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan besi yang digunakan untuk sintesis hemoglobin (Hb). Anemia defisiensi besi pada anak usia sekolah saat ini menjadi masalah gizi yang serius di Indonesia.Tujuan : penelitian ini bertujuan untuk mengetahui gambaran IMT/U, asupan zat besi (Fe), dan inhibitor zat besi (Fe) dengan anemia remaja putrid di SMA Muhammadiyah 7 Sawangan Depok tahun 2018.Metode : jenis penelitian ini ialah deskriptif dengan desain cross sectional. Dengan mengambil sampel menggunakan metode probability sampling dan didapatkan 42 responden yang sesuai dengan kriteria inklusi dan eksklusi. Penelitian dilakukan dengan instrument kuesioner, Semi Quantitative- Food Frequency Questionare (SQ-FFQ), pengukuran tinggi badan, penimbangan berat badan dan pemeriksaan Hb dengan menggunakan alat Easytouch GcHb.Hasil : hasil analisis data meliputi analisis univariat untuk distribusi frekuensi variabel penelitian. Hasil penelitian menunjukkan 18 responden (42.9%) yang menderita mengalami anemia, 32 responden (76.2%) IMT/U tidak normal, 39 responden (92.9%) kurang mengkonsumsi asupan zat besi, dan 30 responden (71.4%) sering mengkonsumsi inhibitor zat besi yang dikarenakan sering mengkonsumsi teh lebih dari 1 kali dalam seminggu.Kesimpulan: Sebagian besar responden tidak mengalami anemia, imt tidak normal, kurang mengkonsumsi asupan zat besi, dan konsumsi inhibitor zat besi yang sering lebih dari 1 kali dalam seminggu.
ANTIBIOTICS PRODUCING BACTERIA ISOLATED FROM FARMLANDS
Authors: Durojaye Hammed Abiodun , Agu Georgia Chinemenwa 
Published: December 2019

The need for new antibiotics has been highlighted recently with the increasing pace of emergence of drug resistance pathogens. Emerging strains of bacteria resistant to most advanced antibiotics have become issues of very important public health concern. Modification of existing antibiotics with the addition of side chains or other chemical group and genomics based drug targeting have been the preferred method of drug development at the corporate level in recent years. In this regard, soil samples were collected from farmlands located in Ibadan in Oyo state, Ago – Iwoye, and Ikenne in Ogun state, Nigeria. Two putative Streptomyces strains and Bacillus strains isolated from the 16 selected farmland soils were characterized and assessed for antibiotic production and activity against a wide range of bacteria including Klebsiella pneumonia, Serratia marscens, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. The extracts of the putative obtained from Streptomyces somaliensis, Streptomyces anulatus, Bacillus megaterium, and Bacillus subtilis showed activities against minimum of 3 and maximum of the 4 of the 7 tested bacteria. Inhibition zones were found to range between 2.0 - 25.0 mm diameters at a concentration of 1ml. The minimum inhibitory concentrations (MICs) of the crude extracts against the tested organisms ranged from 50% and above. Bacillus megaterium, and Streptomyces somaliensis were found to inhibit all the pathogenic bacteria, while S. anulatus was unable to inhibit Proteus vulgaris and Staphylococcus aureus, and B. Subtilis was unable to inhibit Enterococcus faecalis.
Analisis Nilai Tambah Produksi pada Industri Tempe Di Kecamatan Barabai Kabupaten Hulu Sungai Tengah
Authors: Saihani Azwar 
Published: December 2019

This research has two objectives, namely to determine soybean industry overview in sub Barabai and calculating the amount of value added generated by the soybean industry in the Barabai District Hulu Sungai Tengah Regency. The research was conducted at tempe existing tempe industrial business in the District Barabai Hulu Sungai Tengah Regency. The method used in analyzing the data available from industry employers in the Barabai District Hulu Sungai Tengah is to use the formula of gross value added, net value added, and value-added raw materials. The calculations associated with the equipment used, the main raw material, and auxiliary raw materials used in the process of making tempe. Based on the results of research conducted on the existing soybean industry in the District Barabai gross value added generated from all respondents of Rp 56.247.500, net value added generated amounted to Rp 48.062.500, while for value-added raw materials amounting to Rp 125.363/Kg. The existence of the soybean industry in Barabai be able to increase the added value for entrepreneurs tempe
CORRELATION OF P21 EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA WITH CLINICOPATHOLOGIC AND PROGNOSTIC PARAMETERS
Authors: Sadaf Safana , Loya Asif , Mushtaq Sajid , Akhter Noreen , Hussain Raza , Jamshed Arif 
Published: December 2019

Purpose: Head and neck tumours include tumours of nose, paranasal sinuses, oropharynx, larynx and mouth. Squamous cell carcinoma (SCC) is the most common head and neck malignant tumour which accounts for 90% of head and neck malignant tumours. p21 is an important immunohistochemical marker which has signi cant role in predicting prognosis of head and neck SCC (HNSCC). Increased p21 expression in HNSCC is associated with bad prognosis in terms of increased risk of nodal metastasis, increased rate of recurrence and decreased survival rate. The purpose of this study was to evaluate the expression of p21 in HNSCC with various clinicopathologic and prognostic parametres. Materials and Methods: A total of 110 patients (n = 110) of HNSCC (oral cavity n = 98 and laryngeal tumours n = 12) were included in the study which were diagnosed and treated between January 2008 and January 2011 at a tertiary care centre in Pakistan. Mean age was 51 years (age range 15–78). 65 (59%) were male and 45 (41%) were female. Tumours were classi ed as p21 positive when ≥10% tumour cells were immunoreactive for p21. p21 expression was noted and correlated with T-stage, nodal metastasis, perineural and depth of invasion, recurrence and 2-year survival rate. Results: Of 110 cases, p21-positive cases were 88 (80%) compared to 22 (20%) negative. T1–T2 tumours with p21 expression were 59 (67.04%) while 17 cases (77.27%) had negative for p21 (P = 0.44). Amongst T3–T4, 29 cases showed p21 expression (32.96%) while 5 cases (22.73%) were negative (P = 0.44). Nodal metastasis was seen in 51 cases (57.95%) with p21 positivity as compared to 4 cases (18.8%) with no p21 expression (P = 0.0015). Perineural invasion was seen in 15 carcinomas (17.04%) having p21 positivity and 1 case (4.54%) with p21 negativity (P = 0.18). 48 cases (54.54%) had depth of invasion >1 cm with positive p21 as compared to 4 cases (18.18%) without (P value = 0.0035). 39 cases (44.31%) showed recurrence along with p21 expression while 3 cases (13.63%) showed recurrence without (P = 0.0076). 2-year survival rate was 56.81% (n = 88) in p21 positive cases, whereas it was 90.90% (n = 20) those with negative p21 (P = 0.0026). Conclusion: Positive p21 expression in HNSCC correlates with intermediate grade, late stage, increased nodal metastasis, tumour recurrence and decreased survival. p21 should be considered as an important prognostic and predictive marker in HNSCC to detect tumours at early stage and to improve therapy and prognosis. Key words: Head and neck squamous cell carcinoma, lymph node metastasis, p21, recurrence, survival rate
PENGETAHUAN DAN PENERAPAN SASARAN KESELAMATAN PASIEN PADA MAHASISWA SEMESTER 6 DI AKADEMI KEPERAWATAN ADI HUSADA SURABAYA
Authors: Iswati Iswati 
Published: December 2019

Patient safety incident can be done by nursing students when doing clinical practice in hospitals. This happens because of a lack of knowledge about patient safety. The purpose of this study was to identify the relationship between knowledge of patient safety with the implementation of patient safety in the 6th semester student at the Academy of Nursing Adi Husada Surabaya. This type of research is correlational, variable research is knowledge of patient safety and patient safety application. Total population of 143 and the number of samples is 131. The sampling technique is used directly probability sampling type simple random sampling. Measuring instruments used questionnaires and observation sheets. Data analysis using the spearman rank test, (α= 0.05,p=0.01,r= 0.817) indicating Ho refused meaning that there is a relationship between knowledge and application of patient safety. Results of the study recommended the need for the provision of special courses on patient safety for students in the 6th semester nursing Academy Adi Husada Surabaya.
Insiden keselamatan pasien dapat dilakukan oleh mahasiswa saat melakukan praktik klinik di rumah sakit. Hal ini terjadi karena kurangnya pengetahuan tentang keselamatan pasien. Tujuan penelitian ini untuk mengidentifikasi hubungan antara pengetahuan tentang keselamatan pasien dengan penerapan keselamatan pasienpadamahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya. Jenis penelitian ini adalah korelasional, variable penelitiannya adalah pengetahuan tentang keselamatan pasien dan penerapan keselamatan pasien. Jumlah populasi sebanyak 143 dan jumlah sampel adalah 131. Teknik sampling yang digunakan adalah probability sampling jenis simple random sampling. Alat ukur yang digunakan kuesioner dan lembar observasi. Analisis data menggunakan Spearman Rank Test, (α=0.05, p= 0.01, r=0.817) hal ini menunjukkan Ho ditolak artinya terdapat hubungan antara pengetahuan dan penerapan keselamatan pasien. Hasil penelitian merekomendasikan perlunya pemberian mata kuliah khusus tentang keselamatan pasien bagi mahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya.
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Discovery of a Disrupting Open Cluster Far into the Milky Way Halo: A Recent Star Formation Event in the Leading Arm of the Magellanic Stream?
Authors: Price-Whelan Adrian M. , Nidever David L. , Choi Yumi , Schlafly Edward F. , Morton Timothy , Koposov Sergey E. , Belokurov Vasily 
Published: December 2019

Abstract
We report the discovery of a young (

), low-mass (

), metal-poor (

) stellar association at a heliocentric distance

, placing it far into the Milky Way (MW) halo. At its present Galactocentric position

, the association is (on the sky) near the leading arm of the gas stream emanating from the Magellanic Cloud system, but is located

from the Large Magellanic Cloud center on the other side of the MW disk. If the cluster is colocated with H i gas in the stream, we directly measure the distance to the leading arm of the Magellanic stream. The measured distance is inconsistent with Magellanic stream model predictions that do not account for ram pressure and gas interaction with the MW disk. The estimated age of the cluster is consistent with the time of last passage of the leading arm gas through the Galactic midplane; we therefore speculate that this star formation event was triggered by its last disk midplane passage. Most details of this idea remain a puzzle: the Magellanic stream has low column density, the MW disk at large radii has low gas density, and the relative velocity of the leading arm and MW gas is large. However it formed, the discovery of a young stellar cluster in the MW halo presents an interesting opportunity for study. This cluster was discovered with Gaia astrometry and photometry alone, but follow-up DECam photometry was crucial for measuring its properties.
On the Prospect of Using the Maximum Circular Velocity of Halos to Encapsulate Assembly Bias in the Galaxy–Halo Connection
Authors: Zehavi Idit , Kerby Stephen E. , Contreras Sergio , Jiménez Esteban , Padilla Nelson , Baugh Carlton M. 
Published: December 2019

Abstract
We investigate a conceptual modification of the halo occupation distribution approach, using the halos’ present-day maximal circular velocity, V
max, as an alternative to halo mass. In particular, using a semianalytic galaxy formation model applied to the Millennium WMAP7 simulation, we explore the extent that switching to V
max as the primary halo property incorporates the effects of assembly bias into the formalism. We consider fixed number density galaxy samples ranked by stellar mass and examine the variations in the halo occupation functions with either halo concentration or formation time. We find that using V
max results in a significant reduction in the occupancy variation of the central galaxies, particularly for concentration. The satellites’ occupancy variation on the other hand increases in all cases. We find effectively no change in the halo clustering dependence on concentration, for fixed bins of V
max compared to fixed halo mass. Most crucially, we calculate the impact of assembly bias on galaxy clustering by comparing the amplitude of clustering to that of a shuffled galaxy sample, finding that the level of galaxy assembly bias remains largely unchanged. Our results suggest that while using V
max as a proxy for halo mass diminishes some of the occupancy variations exhibited in the galaxy–halo relation, it is not able to encapsulate the effects of assembly bias potentially present in galaxy clustering. The use of other more complex halo properties, such as V
peak, the peak value of V
max over the assembly history, provides some improvement and warrants further investigation.