bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of the carrier addition and spray drying temperatures on physicochemical properties of microencapsulated carrot juice powder
Authors: Janiszewska‐Turak Emilia , Bąk Paulina , Krzykowski Andrzej , Witrowa‐Rajchert Dorota 
Published: November 2020

SummaryThe objective of this study was to determinate the influence of carrier addition and spray drying temperatures (160 or 200°C) on physicochemical properties of spray‐dried carrot juice powder. As carriers, maltodextrin and gum Arabic in different proportions were used. In powders were determined the following: moisture content, water activity, apparent density, size of particles, colour and carotenoids content. The content of carotenoids in powders prepared from solutions with juice to carrier ratio 2:3 was 324.3–406.6 mg/kg d.m., while in powders with a J:C = 3:2 values ranged from 576.7 to 637.7 mg/kg d.m. The highest content of carotenoids and the most yellow colour were observed in powders with 1:3 gum Arabic to maltodextrin ratio. Powders with the highest amount of gum Arabic have the highest diameter and the lowest water activity. High inlet temperature caused brighter colour of powders, higher dry matter content, lower water activity and apparent density of powders.
A 3‐year longitudinal study of the association of physical activity and sedentary behaviours with childhood obesity in China: The childhood obesity study in China mega‐cities
Authors: Sun Xiaomin , Zhao Bingtong , Liu Jin , Wang Yun , Xu Fei , Wang Youfa , Xue Hong 
Published: November 2020

SummaryObjectivesExamine school children's physical activity (PA) and sedentary behaviours (SB) during 2015 to 2017 in China, and study their associations with children's weight status and relevant gender differences.MethodsThis open cohort study included students from five major cities (Beijing, Shanghai, Xi'an, Nanjing, and Chengdu) across China. Data were collected from students in 2015, 2016, and 2017 (n = 5535) and from their parents and school personnel. Children's weight, height, and waist circumference were measured. SB and PA factors were evaluated using questionnaires. Mixed‐effects models examined the relationship between weight status and PA‐/SB‐associated factors using this longitudinal data.ResultsThese children had high rates of obesity (12.4%, 95% CI 11.6%‐13.3%) and central obesity (28.1%, 95% CI 26.9%‐29.3%) during 2015 to 2017. Boys were more likely to have obesity than girls (16.5% vs 8.4%, respectively) as well as centrally obesity (36.3% vs 19.8%, respectively) and spent more time in screen viewing than girls (hours/week ± SD: 2015, 1.8 ± 2.5 vs 1.5 ± 2.0; 2016, 2.0 ± 2.4 vs 1.8 ± 2.5; 2017, 1.7 ± 2.3 vs 1.4 ± 2.1 hours/week). Those who walked <5 minutes on their average daily walk to school were more likely to have obesity (OR: 1.96, 95% CI 1.03‐3.73) than those who spent ≥15 minutes on walking to school. When stratified by gender, this higher risk was only observed in girls (OR: 3.01, 95% CI 1.09‐8.35). Children who spent more time in screen viewing were more likely to have obesity (OR: 1.13, 95% CI 1.06‐1.21) and have central obesity (OR: 1.05, 95% CI 1.02‐1.09). The association for obesity was consistent in boys and girls (boys, OR: 1.15, 95% CI 1.05‐1.25; girls, OR: 1.12, 95% CI 1.00‐1.24).ConclusionsMore screen time and less walking time were risk factors for developing obesity in urban Chinese children. The associations varied by gender.
Randomised clinical study of plaque removal efficacy of an electric toothbrush in primary and mixed dentition
Authors: Davidovich Esti , Ccahuana‐Vasquez Renzo A. , Timm Hans , Grender Julie , Zini Avi 
Published: November 2020

AbstractBackgroundClinical investigations of electric toothbrushes in young children are limited.AimTo assess plaque reduction efficacy of an oscillating‐rotating electric versus manual toothbrush in a paediatric population in primary and mixed dentitions.DesignIn this randomised, single‐brushing, 2‐treatment, 4‐period, replicate‐use crossover study, subjects were divided into 2 age groups (3‐6 years; 7‐9 years) and assigned to a treatment sequence involving an Oral‐B Kids electric brush and a manual brush control. Plaque was assessed pre‐ and post‐brushing (Turesky Modified Quigley‐Hein Plaque Index). Parents brushed the teeth of their children aged 3‐6 years, whereas children aged 7‐9 years brushed their own teeth under supervision. Plaque removal scores were analysed for brush differences in each age group separately using an analysis of covariance for crossover design.ResultsForty‐one children (n = 20, 3‐6 years; n = 21, 7‐9 years) completed the study. For the primary dentition in children 3‐6 years, the electric brush reduced 32.3% more plaque than the manual brush (P = .005). For the mixed dentition in children 7‐9 years, the electric brush reduced 51.9% more plaque than the manual brush (P < .001).ConclusionsAn electric toothbrush reduced significantly more plaque than a manual toothbrush in 2 paediatric age groups.
The role of peer‐to‐peer voice in severe work environments: organisational facilitators and barriers
Authors: Loudoun Rebecca , Townsend Keith , Wilkinson Adrian , Mowbray Paula K. 
Published: November 2020

AbstractEncouraging and facilitating employee voice among frontline employees is important in organisations to draw out problems and issues that can potentially be addressed and mitigated by organisational policies and practices. Using Conservation of Resources theory, this study focuses on paramedics and the formal and informal voice mechanisms used to safeguard their well‐being. We observe that paramedics are often unwilling to use formal support mechanisms, at least in the first instance immediately following exposure to a traumatic event, but they see informal peer‐to‐peer voice as critical in preventing resource loss and regaining resources for subsequent call‐outs. We also found that without an awareness of the importance of this support mechanism, changes in work organisation can unintentionally and unknowingly limit their capacity to engage in this form of support. Losing peer‐to‐peer voice can lead to the build‐up of stress that could otherwise be mitigated, resulting in diminished well‐being.
Maresin 1 attenuates pro‐inflammatory activation induced by β‐amyloid and stimulates its uptake
Authors: Wang Ying , Leppert Axel , Tan Shuai , van der Gaag Bram , Li Nailin , Schultzberg Marianne , Hjorth Erik 
Published: November 2020

AbstractAlzheimer's disease (AD) is the most common dementia, characterized by pathological accumulation of β‐amyloid (Aβ) and hyperphosphorylation of tau protein, together with a damaging chronic inflammation. The lack of effective treatments urgently warrants new therapeutic strategies. Resolution of inflammation, associated with beneficial and regenerative activities, is mediated by specialized pro‐resolving lipid mediators (SPMs) including maresin 1 (MaR1). Decreased levels of MaR1 have been observed in AD brains. However, the pro‐resolving role of MaR1 in AD has not been fully investigated. In the present study, human monocyte‐derived microglia (MdM) and a differentiated human monocyte cell line (THP‐1 cells) exposed to Aβ were used as models of AD neuroinflammation. We have studied the potential of MaR1 to inhibit pro‐inflammatory activation of Aβ and assessed its ability to stimulate phagocytosis of Aβ42. MaR1 inhibited the Aβ42‐induced increase in cytokine secretion and stimulated the uptake of Aβ42in both MdM and differentiated THP‐1 cells. MaR1 was also found to decrease chemokine secretion and reduce the associated increase in the activation marker CD40. Activation of kinases involved in transduction of inflammation was not affected by MaR1, but the activity of nuclear factor (NF)‐κB was decreased. Our data show that MaR1 exerts effects that indicate a pro‐resolving role in the context of AD and thus presents itself as a potential therapeutic target for AD.
Effects of dietary fish oil and alpha‐tocopherol supplementation on selected blood parameters and fatty acid profiles in mares and their foals
Authors: Danyer Erdem , Bilal Tanay 
Published: November 2020

AbstractThe effects of fish oil (40 ml/day) supplementation, with or without synthetic all‐rac‐alpha‐tocopherol‐acetate (2,500 IU/day), during the last 65 days before expected parturition were investigated in 15 adult mares (553 ± 24 kg BW) and their foals. Mares were assigned to one of three diets: control (n = 5), control plus fish oil and alpha‐tocopherol (n = 4; FO + AT) or control with just fish oil (n = 6; FO). Blood samples were obtained from the mares before a 15‐day dietary adaptation period (T1) and from mares and foals the first (T2) and fifth (T3) days post‐partum. Colostrum was collected at T2 and milk at T3. Routine haematological, biochemical and alpha‐tocopherol analyses were undertaken on all blood samples. Fatty acid concentrations were determined in the foal serum and alpha‐tocopherol concentrations measured in the milk and colostrum. Diet had no effect on haematology or biochemistry in the mares. Alpha‐tocopherol concentrations were significantly higher at T2 & T3 in the FO + AT mares. Foal WBCs were higher in FO (11.33 ± 2.59 × 109/l), comparing to FO + AT and control groups (9.18 ± 1.24 × 109/l and 7.26 ± 1.03 × 109/l, respectively), at T3 (p < .05). There was no significant effect of the fish oil supplementation on the foal's serum fatty acid profile. In the FO + AT group, both colostrum and milk alpha‐tocopherol concentrations (2.56 ± 0.36 and 1.36 ± 0.22 µg/ml, respectively) were higher compared than those of the FO group (1.33 ± 0.39 and 0.72 ± 0.31 µg/ml, respectively;p < .05). Additional 2,500 IU/day of synthetic alpha‐tocopherol in the last 65 days of pregnancy increased alpha‐tocopherol concentrations in colostrum and milk and the foal's serum. 40 ml/day fish oil, however, did not significantly increase serum eicosapentaenoic acid and docosahexaenoic acid concentrations in the foals.
Inclusive Education in Asia: Insights From Some Country Case Studies
Authors: Faragher Rhonda , Chen Mo , Miranda Lucena , Poon Kenneth , Rumiati  , Chang Feng‐Ru , Chen Holly 
Published: November 2020

AbstractAcross Asia, countries have signed the UNCRPD and to a greater or lesser extent are pursuing inclusive education (IE). In this article, we present case studies from Singapore, Indonesia, Philippines, and China analyzing them for common themes around the education of students intellectual and developmental disabilities (IDD), and noting commonalities, challenges, and emerging issues. While the definition of IE (being the philosophy, process and practice of welcoming, valuing and supporting all learners in general education environments) and the conceptual distinction between integration and segregation are clear in the UNCRPD and subsequent comments, the terminology used in some of the countries is inconsistent with these definitions. This makes interpretation of reports from government instrumentalities difficult. In some cases, misuse of terminology allows justification of practices that are contrary to the UNCRPD. Terminology differences coupled with challenges of finding data related to the education of children with IDD, if the data exist, make a regional analysis of progress towards IE complex. In our paper, we have drawn on previous reviews and reports to discuss common issues and make suggestions for ways forward. Our findings add to the few other reviews from Asia on IE and draw attention to the continuing need for improved access to any education at all for learners with IDD. Provision of IE is caught up in dilemmas in the region about teacher preparation and professional learning, and how to provide specialist support in inclusive settings. School structure decisions including staffing provision and class sizes affect the education outcomes of students with IDD. School leadership, with the fundamental role of translating policy into practice, is critical for the development of IE and must be aligned with system and country priorities. Collaboration across the region has the potential to share best practice and continue to improve the educational opportunities for learners with IDD.
Predictors of technique failure and mortality on peritoneal dialysis: An analysis of New Zealand peritoneal dialysis registry data
Authors: Hayat Ashik , Saweirs Walaa 
Published: November 2020

AbstractAimTechnique failure is a major disadvantage associated with peritoneal dialysis (PD). This study aimed to analyse the demographic and risk predictors of technique failure and mortality in patients on PD.MethodsAll incidental PD patients registered on the New Zealand Peritoneal dialysis registry (NZPDR) from January 1995 to December 2014 were included in the study. The primary outcomes were time to technique failure and its specific causes, while as the secondary outcome was time to death. Risk predictors of technique failure and mortality were analysed using multivariate Cox proportional hazards (PH) regression model. Besides, competitive risk regression analysis was undertaken to analyse the effect of death as a competing event to technique failure.ResultsOf 6379 patients, there were 2993 (46.9%) episodes of technique failure and 2684 (42%) deaths. The crude technique failure and mortality rates were 165 ± 5.90 and 147.9 ± 5.50 (mean ± SD)/1000 patient‐years, respectively. Hazards of technique failure were lower in older individuals above 60 years, HR 0.72 (95% CI 0.67‐0.79), larger centres, HR 0.89 (95% CI 0.79‐1.00) and higher with coiled catheters, HR 1.26 (95% CI 1.16‐1.37). Early nephrology referral, continuous ambulatory peritoneal dialysis (CAPD) and Asian ethnicities were associated with better technique survival. Infections were the major cause of technique failure (58.4%) with peritonitis being the leading cause (30.2%).ConclusionThere are multiple factors associated with risk of technique failure, therefore it is persuasive to construct a mathematical model for early prediction, for a planned transition to HD.
NtMYB12a acts downstream of sucrose to inhibit fatty acid accumulation by targeting lipoxygenase and SFAR genes in tobacco
Authors: Wang Zhong , Li Ze Feng , Wang Shan Shan , Xiao Yan Song , Xie Xiao Dong , Wu Ming Zhu , Yu Jin Long , Cheng Li Rui , Yang Ai Guo , Yang Jun 
Published: November 2020

AbstractMYB12 promotes flavonol biosynthesis in plants by targeting several early biosynthesis genes (EBGs) of this pathway. The transcriptions of these EBGs are also induced by sucrose signal. However, whether MYB12 is activated by sucrose signal and what the other roles MYB12 has in regulating plant metabolism are poorly understood. In this study, two NtMYB12 genes were cloned from Nicotiana tabacum. Both NtMYB12a and NtMYB12b are involved in regulating flavonoids biosynthesis in tobacco. NtMYB12a is further shown to inhibit the accumulation of fatty acid (FA) in tobacco leaves and seeds. Post‐translational activation and chromatin immunoprecipitation assays demonstrate that NtMYB12a directly promotes the transcriptions of NtLOX6, NtLOX5, NtSFAR4 and NtGDSL2, which encode lipoxygenase (LOX) or SFAR enzymes catalyzing the degradation of FA. NtLOX6 and NtLOX5 are shown to prevent the accumulation of FA in the mature seeds and significantly reduced the percentage of polyunsaturated fatty acids (PUFAs) in tobacco. Sucrose stimulates the transcription of NtMYB12a, and loss function of NtMYB12a partially suppresses the decrease of FA content in tobacco seedlings caused by sucrose treatment. The regulation of sucrose on the expression of NtLOX6 and NtGDSL2 genes is mediated by NtMYB12a, whereas those of NtLOX5 and NtSFAR4 genes are independent of sucrose.
Sequential Aggregation of Probabilistic Forecasts—Application to Wind Speed Ensemble Forecasts
Authors: Zamo Michaël , Bel Liliane , Mestre Olivier 
Published: November 2020

AbstractIn numerical weather prediction (NWP), the uncertainty about the future state of the atmosphere is described by a set of forecasts (called an ensemble). All ensembles have deficiencies that can be corrected via statistical post-processing methods. Several ensembles, based on different NWP models, exist and may be corrected using different statistical methods. These raw or post-processed ensembles can thus be combined. The theory of prediction with expert advice allows us to build combination algorithms with theoretical guarantees on the forecast performance. We adapt this theory to the case of probabilistic forecasts issued as stepwise cumulative distribution functions, computed from raw and post-processed ensembles. The theory is applied to combine wind speed ensemble forecasts. The second goal of this study is to explore the use of two forecast performance criteria: the continuous ranked probability score (CRPS) and the Jolliffe–Primo test. The usual way to build skilful probabilistic forecasts is to minimize the CRPS. Minimizing the CRPS may not produce reliable forecasts according to the Jolliffe–Primo test. The Jolliffe–Primo test generally selects reliable forecasts, but could lead to issuing suboptimal forecasts in terms of CRPS. We propose to use both criteria to achieve reliable and skilful probabilistic forecasts.
Controls on fluvial meander‐belt thickness and sand distribution: Insights from forward stratigraphic modelling
Authors: Yan Na , Colombera Luca , Mountney Nigel P. 
Published: November 2020

AbstractFluvial point‐bar evolution commonly involves multiple stages of bar development driven by changes in the style of meander transformations. Complicated planform morphologies are widely recognized in remote‐sensing imagery, but the relationships between meander‐bend evolutionary behaviour and stratigraphic architecture, facies distribution, and sand volumes remain poorly understood. This study applies a geometric forward stratigraphic model (Point‐Bar Sedimentary Architecture Numerical Deduction – ‘PB‐SAND’) to simulate the internal sedimentary architecture of 24 meander‐belt segments that evolved via a broad range of meander‐bend transformation styles. Modelling inputs are constrained by channel trajectories inferred from high‐resolution Light Detection and Ranging (LiDAR) datasets, lithological information from a sedimentological database (Fluvial Architecture Knowledge Transfer System – ‘FAKTS’) and geological knowledge of trends in point‐bar lithology (for example, decrease in sand proportion with sinuosity, downstream of bend apices, and beyond the transition from point‐bar to counter‐point‐bar deposits) and in channel bathymetry (depth variations across pools and riffles). Modelling results are used to explore how the relative distribution of sand and mud is controlled by the styles of point‐bar transformation, quantified by the relative degree of meander translation versus expansion, and by the amount of bend rotation. The 24 models are classified into three groups based on cluster analysis of their mean migration angle, mean apex rotation, mean sinuosity, standard deviation of channel circular variance and preservation ratio; these quantities are known to be controlled by meander transformation types. Quantitative comparisons across these groups and relationships between metrics of planform change and quantifications of point‐bar deposits demonstrate how meander planform evolution controls point‐bar thickness and sand volume. Locally, the thickness of sand in bar deposits is controlled by the interplay of facies trends and spatial variations in bar thickness that reflect bathymetric changes, both related to local hydrodynamics. The proposed workflow establishes linkages between planform morphologies and three‐dimensional facies distributions; it can be employed to characterize the distribution of subsurface porous volumes where the planform history of meander bends can be reconstructed.
A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance
Authors: Reinhart Erin F. , Litt Nicole A. , Katzenell Sarah , Pellegrini Maria , Yamamoto Ai , Ragusa Michael J. 
Published: November 2020

AbstractAutophagy‐linked FYVE protein (ALFY) is a large, multidomain protein involved in the degradation of protein aggregates by selective autophagy. The C‐terminal FYVE domain of ALFY has been shown to bind phosphatidylinositol 3‐phosphate (PI(3)P); however, ALFY only partially colocalizes with other FYVE domains in cells. Thus, we asked if the FYVE domain of ALFY has distinct membrane binding properties compared to other FYVE domains and whether these properties might affect its function in vivo. We found that the FYVE domain of ALFY binds weakly to PI(3)P containing membranes in vitro. This weak binding is the result of a highly conserved glutamic acid within the membrane insertion loop in the FYVE domain of ALFY that is not present in any other human FYVE domain. In addition, not only does this glutamic acid reduce binding to membranes in vitro and inhibits its targeting to membranes in vivo, but it is also important for the ability of ALFY to clear protein aggregates.
COVID-19 emergency and palliative medicine: an intervention model’
Authors: Riva Luca , Caraceni Augusto , Vigorita Federico , Berti Jacopo , Martinelli Maria Pia , Crippa Matteo , Pellegrini Giacomo , Scaccabarozzi Gianlorenzo 
Published: November 2020

ObjectivesThe aim of this work is to describe the multidisciplinary model of intervention applied and the characteristics of some COVID-19 patients assisted by the hospital palliative care unit (UCP-H) of an Italian hospital in Lombardy, the Italian region most affected by the COVID-19 pandemic.MethodsA retrospective study was conducted on patients admitted to the A. Manzoni Hospital (Lecco, Lombardy Region, Italy) and referred to the UCP-H between 11 March 2020 and 18 April 2020, the period of maximum spread of COVID-19 in this area. Data were collected on the type of hospitalisation, triage process, modality of palliative care and psychological support provided.Results146 COVID-10 patients were referred to the UCP-H. Of these, 120 died during the observation time (82%) while 15 (10.2%) improved and were discharged from the UCP-H care. 93 had less favourable characteristics (rapid deterioration of respiratory function, old age, multiple comorbidities) and an intensive clinical approach was considered contraindicated, while 48 patients had more favourable presentations. Mean follow-up was 4.8 days. A mean of 4.3 assessments per patient were performed. As to respiratory support, 94 patients were treated with oxygen only (at different volumes) and 45 with Continuous Positive Airway Pressure (CPAP).ConclusionThe ongoing pandemic highlighted the need for dedicated palliative care teams and units for dying patients. This work highlights how palliative medicine specialist can make a fundamental contribution thanks to their ability and work experience in an organised multiprofessional context.
Collider constraints on a dark matter interpretation of the XENON1T excess
Authors: Primulando R. , Julio J. , Uttayarat P. 
Published: November 2020

AbstractIn light of the excess in the low-energy electron recoil events reported by XENON1T, many new physics scenarios have been proposed as a possible origin of the excess. One possible explanation is that the excess is a result of a fast moving dark matter (DM), with velocity$$v\sim $$v∼0.05–0.20 and mass between 1 MeV and 10 GeV, scattering off an electron. Assuming the fast moving DM-electron interaction is mediated by a vector particle, we derive collider constraints on the said DM-electron interaction. The bounds on DM-electron coupling is then used to constrain possible production mechanisms of the fast moving DM. We find that the preferred mass of the vector mediator is relatively light ($$\lesssim $$≲1 GeV) and the coupling of the vector to the electron is much smaller than the coupling to the fast moving DM.