bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythema exsudativum multiforme, Stevens‐Johnson‐Syndrom/toxische epidermale Nekrolyse – Diagnostik und Therapie
Authors: Grünwald Pavel , Mockenhaupt Maja , Panzer Rüdiger , Emmert Steffen 
Published: June 2020

ZusammenfassungÜber ein Jahrhundert herrschten Unklarheit und Kontroverse über die Abgrenzung der Entitäten Erythema exsudativum multiforme (EEM), Stevens‐Johnson‐Syndrom (SJS) und Toxische epidermale Nekrolyse (TEN), bis schließlich 1993 eine internationale Konsensusklassifikation erschien. Für die Definition der Krankheitsbilder sind demnach die Morphe der Einzelläsionen und das Verteilungsmuster entscheidend. Ätiopathogenetisch liegt dem EEM in der überwiegenden Zahl der Fälle eine Infektion (vor allem mit dem Herpes‐simplex‐Virus oderMycoplasma pneumoniae), SJS/TEN jedoch meist eine Arzneimittelreaktion zugrunde. Die Prognoseeinschätzung im Falle einer SJS/TEN‐Erkrankung kann und sollte anhand des SCORTEN (Score of toxic epidermal necrolysis) erfolgen.Während für EEM eine supportive Therapie allgemein als ausreichend angesehen wird, besteht über die systemische Therapie der schwerer verlaufenden SJS/TEN‐Erkrankungen weiterhin Unklarheit. Aufgrund fehlender hochqualitativer Therapiestudien und teilweise widersprüchlicher Ergebnisse können aktuell keine eindeutigen Empfehlungen für eine immunmodulierende Therapie gegeben werden. Einem raschen immunsuppressiven Effekt steht prinzipiell ein erhöhtes Infektionsrisiko gegenüber. Vor allem für Ciclosporin mehren sich allerdings Hinweise, dass es das Fortschreiten der Hautablösung stoppen und die Letalität von SJS/TEN senken kann.Unterstützung bei der Diagnostik und Therapie dieser Krankheitsentitäten kann vom Dokumentationszentrum schwerer Hautreaktionen (dZh) an der Universitätsklinik für Dermatologie Freiburg eingeholt werden.
Rosazea und periorale Dermatitis: Eine monozentrische, retrospektive Analyse des klinischen Erscheinungsbildes von 1032 Patienten
Authors: Hoepfner Andreas , Marsela Enklajd , Clanner‐Engelshofen Benjamin M. , Horvath Orsolya N. , Sardy Miklos , French Lars E. , Reinholz Markus 
Published: June 2020

ZusammenfassungHintergrundRosazea ist eine häufige chronisch‐entzündliche Hauterkrankung, die circa 5,5 % der erwachsenen Bevölkerung betrifft. Unser Ziel war es, die Prävalenz und Epidemiologie von Rosazea und perioraler Dermatitis (POD) in einer ambulanten, universitären Versorgungseinrichtung zu untersuchen.MethodenWir analysierten retrospektiv die medizinischen Daten von Patienten mit der bestätigten Diagnose Rosazea oder perioraler Dermatitis (POD), die sich während eines Zeitraums von drei Jahren in der Ambulanz unseres Universitätsklinikums vorstellten.ErgebnisseVon 1032 Patienten wurde bei 81,5 % Rosazea und bei 18,5 % POD diagnostiziert. Die Gesamtprävalenz betrug 1,4 % für Rosazea und 0,3 % für POD. 69,3 % der analysierten Patienten waren weiblich. Das Durchschnittsalter betrug 49,3 ± 17,7 (1–92) Jahre. Das Durchschnittsalter der Frauen war niedriger als das der Männer. Patienten mit POD waren jünger und überwiegend weiblich, während Patienten mit phymatöser Rosazea älter und überwiegend männlich waren. Die häufigsten Phänotypen waren Rosacea papulopustulosa (68,4 %), Rosacea erythematosa‐teleangiectatica (22,5 %) und phymatöse Rosazea (8,0 %). Bei 15,8 % der Patienten wurden Sonderformen der Rosazea diagnostiziert; am häufigsten waren okuläre Rosazea (6,9 %) und Steroid‐induzierte Rosazea (5,4 %).SchlussfolgerungenDie große Patientenkohorte, die in unserer Studie analysiert wurde, ermöglicht eine gute Einschätzung der Häufigkeit von Subtypen und Sonderformen der Rosazea sowie der perioralen Dermatitis in der Ambulanz einer klinisch‐universitären Einrichtung.
Developing Double Frontier Version of Dynamic Network DEA Model: Assessing Sustainability of Supply Chains
Authors: Samavati Tahmoures , Badiezadeh Taliva , Saen Reza Farzipoor 
Published: June 2020

ABSTRACTData envelopment analysis (DEA) is one of the techniques for assessing sustainability of supply chains. There have been raising interests in incorporating sustainability in supply chain operations. The objective of this article is to develop a dynamic network DEA (DNDEA) model for calculating both optimistic and pessimistic efficiency and effectiveness. Also, our proposed model can deal with undesirable outputs. Our model can rank sustainable supply chains in terms of optimistic and pessimistic efficiency and effectiveness. A case study demonstrates efficacy of our proposed model.
Biomarkers of seizure severity derived from wearable devices
Authors: Beniczky Sándor , Arbune Anca A. , Jeppesen Jesper , Ryvlin Philippe 
Published: June 2020

AbstractBesides triggering alarms, wearable seizure detection devices record a variety of biosignals that represent biomarkers of seizure severity. There is a need for automated seizure characterization, to identify high‐risk seizures. Wearable devices can automatically identify seizure types with the highest associated morbidity and mortality (generalized tonic‐clonic seizures), quantify their duration and frequency, and provide data on postictal position and immobility, autonomic changes derived from electrocardiography/heart rate variability, electrodermal activity, respiration, and oxygen saturation. In this review, we summarize how these biosignals reflect seizure severity, and how they can be monitored in the ambulatory outpatient setting using wearable devices. Multimodal recording of these biosignals will provide valuable information for individual risk assessment, as well as insights into the mechanisms and prevention of sudden unexpected death in epilepsy.
Headache as the Presenting Symptom in 2 Patients With COVID‐19 and a History of Migraine: 2 Case Reports
Authors: Singh Jyotika , Ali Ashhar 
Published: June 2020

The coronavirus disease 2019 (COVID‐19) pandemic has now affected more than 5 million people globally. Typical symptoms include fever, cough, and shortness of breath. Patients with underlying medical comorbidities such as cardiovascular disease and diabetes are more likely to become severely ill. To date there is limited information on how COVID‐19 affects patients with a history migraine. Here, we present the cases of 2 women with a history of migraine whose first symptom of COVID‐19 was a severe persistent headache.
Electrolytic in‐process dressing grinding performance of a multi‐layer brazed coarse‐grained diamond wheel using an electrolyte containing carbon microspheres
Authors: Wu Qiaoping , Song Kun , Ouyang Zhiyong , Wang Yu 
Published: June 2020

AbstractAn electrolyte containing carbon microspheres (CMSs) was prepared for electrolytic dressing of a multi‐layer brazed coarse‐grained diamond wheel. And the influence of CMSs on the electrolytic in‐process dressing grinding performance of Si3N4 ceramics with the brazed wheel was investigated. The results indicate that the CMSs can increase the electrolytic capacity of the electrolyte, which increases the thickness of the oxide film formed on the brazed wheel surface, and the worn diamond grit can easily fall off from the bonding matrix. In addition, the CMSs were adsorbed and distributed on the film, which effectively improves its densification and adhesion strength. This thicker and denser oxide film can improve the polishing effect of the brazed wheel. Thus, a better machined surface quality and less subsurface damage of the Si3N4 ceramics can be obtained by the multi‐layer brazed coarse‐grained diamond wheel with electrolyte containing CMSs.
Unusual concentration induced antithermal quenching of the Eu2+ emission at 490 nm in Sr4Al14O25:Eu2+ for near ultraviolet excited white LEDs
Authors: Liu Huailu , Liu Xiaoqi , Wang Xiu , Peng Mingying , Xiong Puxian , Chen Yan , Wang Yafei , Lei Bingfu , Zeng Qingguang 
Published: June 2020

AbstractThermal quenching of phosphor is an important challenge for its practical application in phosphor‐converted white light‐emitting diodes (pc‐WLEDs) and it usually becomes aggravated with the increase of activator concentration. Conversely, this work finds the thermal quenching of Eu2+ emission at 490 nm in Sr4Al14O25:Eu2+ does not follow this in the temperature range of 300 to 480 K, and the rate of it is even slowed down as the concentration of Eu2+ increases. However, at the same time, the experiment on three heating‐cooling cycles of Sr4Al14O25:Eu2+ reveals that the thermal degradation of Eu2+ emission becomes improved. Once Eu2+ ions are doped into Sr4Al14O25, they will prefer substituting for the 10‐ and 7‐coordinated strontium sites Sr1 and Sr2, respectively. The emission centers Eu1 and Eu2, therefore, appear. The abnormal phenomenon is perhaps partly due to the enhanced energy transfer from the emission center Eu1 at 407 nm to the one Eu2 at 490 nm. It is also found interesting that the introduction of AlN can enhance the emission of Sr4Al14O25:Eu2+ without leading to the deterioration of thermal degradation. In the end, a prototype of pc‐WLED was fabricated with Sr4Al14O25:Eu2+ to demonstrate the application of white lighting. This work is not only beneficial to the understanding of the relationship between concentration and thermal quenching, but also conducive to the design of the heavily doped phosphor for WLEDs with better resistance to thermal quenching.
Embedding Sustainability Performance and Long‐Term Strategy in the Earnings Call
Authors: Eckerle Kevin , Whelan Tensie , Tomlinson Brian 
Published: June 2020

The practice of disclosing corporate Environmental, Social and Governance performance information continues to evolve, and the frequency of ESG disclosures in investor‐facing discussions, including Investor Day presentations and non‐deal roadshows, continues to grow. But even with these developments, the corporate‐investor dialogue about ESG and long‐term strategy, and their expected effects on long‐run profitability and value, has continued to lag. This seems particularly evident in the quarterly earnings call.In this article, the authors review the work of NYU's Center for Sustainable Business, in collaboration with Chief Executives for Corporate Purpose (CECP), in encouraging companies to work ESG themes and performance into their quarterly earnings calls. After discussing the reasons for the relatively slow progress in this important disclosure venue, including interviews with sell‐side analysts, the authors propose practical approaches that can guide companies, regardless of industry or market cap, in delivering this content in a way that is valuable to both buy‐side and sell‐side equity analysts.
Direct and indirect vulnerability of economic sectors to water scarcity: A hotspot analysis of the Indian economy
Authors: Bogra Shelly , Bakshi Bhavik R. 
Published: June 2020

AbstractResource scarcity is capable of affecting economic activity. Though the dependence of direct users is easily acknowledged, indirect vulnerability imposed on downstream sectors of the economic system is not as easily understood. In the context of growing water scarcity across India, this study maps the dependence of prominent sectors of the Indian economy to the water‐withdrawal model of India (Bogra, Bakshi, & Mathur, 2016). From the suppliers' perspective, the results indicate that embodied water of the largest direct water‐withdrawing food sectors namely, Paddy, Wheat, and Sugarcane (PWS) is indirectly consumed mostly by the consumptive food sectors. However, from the users' perspective, even non‐food sectors exhibit a significant dependence on the embodied water of PWS. Further, blue‐water‐based structural path analysis (SPA) of Paddy and Wheat indicate significant contributions to Land transport, Construction, and Beverages, among others, whereas Land transport is important in terms of green water too. The out‐degree measure indicates a higher dependence of the economy on Electricity (blue water) and Forestry (green water) sectors. Specifically, infrastructural sectors exhibit a significant dependence on Electricity; whereas Forestry products contribute to non‐food sectors. State‐wise water‐scarcity indices (WSIs) indicate higher dependence of Electricity on scarce surface‐water flows of north‐western and central states, whereas forested areas in the north and north‐eastern parts of India exhibit lowest ground WSIs. By integrating regional flows with sectoral dependencies, it is observed that the risk to a reduction of the economy's throughput is higher from water withdrawn by Electricity compared to food sectors, PWS.
Effect of sugarcane bagasse addition on physical, chemical, and sensory properties of oat flour and banana cake
Authors: Silva Amanda S. , Correa Luana G. , Kanai Rafaela S. S. , Shirai Marianne A. 
Published: June 2020

AbstractThe objective of this work was to evaluate the effect of sugarcane bagasse (SB) addition on chemical, physical, and sensory properties of the oat flour and banana cakes. The SB was added in the amount of 3 g and 6 g/100 g solids (BC3 and BC6) to obtain cakes considered “source of fiber” and “high in fiber content,” respectively. The addition of SB did not alter the chemical composition of the cakes except the dietary fiber which was higher in the BC6. The firmness of the cake increased with SB concentration, but this fact did not interfere in the sensorial acceptance of the product. The production of oat flour and banana cakes containing “high fiber content” with good sensorial acceptance was possible and demonstrated the reuse of an agro‐industrial residue widely available the sugar and alcohol industry.
Towards a Theological and Synodal Response to the Abuse Crisis
Authors: Goulding Gill 
Published: June 2020

AbstractBeneath the appalling incidents of sexual abuse in the Church, there are key theological issues. Along with Pope Francis, I argue that central to this crisis is the abuse of power. I propose that part of the way to address this is through a discussion of the appropriate use of power; and perhaps the best way to think about the appropriate use of power is through the notion of the appropriate use of authority - as service. Here, I suggest there could be the beginning of an ecclesial response that would involve the wider Church along the developing lines of synodality that Pope Francis promotes. After an initial introduction focusing the abuse of authority and the call for a greater synodal way of relating in the Church, there is consideration of the vital foundation of authority rooted in intimacy with God. This leads to an exploration of the centrality of the example of Christ for authentic exercise of authority. Dialogue is seen as a healthy expression of authority, while living the tensions in the exercise of authority suggests a true witness to authority could be the formation of communities of discourse bearing many of the hallmarks of the synodal process.
Evolution of the metal hyperaccumulation and hypertolerance traits
Authors: Manara Anna , Fasani Elisa , Furini Antonella , DalCorso Giovanni 
Published: June 2020

AbstractTo succeed in life, living organisms have to adapt to the environmental issues to which they are subjected. Some plants, defined as hyperaccumulators, have adapted to metalliferous environments, acquiring the ability to tolerate and accommodate high amounts of toxic metal into their shoot, without showing symptoms of toxicity. The determinants for these traits and their mode of action have long been the subject of research, whose attention lately moved to the evolution of the hypertolerance and hyperaccumulation traits. Genetic evidence indicates that the evolution of both traits includes significant evolutionary events that result in species‐wide tolerant and accumulating backgrounds. Different edaphic environments are responsible for subsequent refinement, by local adaptive processes, leading to specific strategies and various degrees of hypertolerance and hyperaccumulation, which characterize metallicolous from non‐metallicolous ecotypes belonging to the same genetic unit. In this review, we overview the most updated concepts regarding the evolution of hyperaccumulation and hypertolerance, highlighting also the ecological context concerning the plant populations displaying this fascinating phenomenon.
Dermatologic conditions in Down syndrome: A single‐center retrospective chart review
Authors: Rork Jillian F. , McCormack Lindsay , Lal Karan , Wiss Karen , Belazarian Leah 
Published: June 2020

AbstractBackgroundCurrent literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders.ObjectiveWe sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists.MethodsThis was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018.ResultsFolliculitis was the most common diagnosis overall (30.7%), followed by seborrheic dermatitis (26.7%) and hidradenitis suppurativa (22.8%). Eczematous dermatitis, alopecia areata, and xerosis were the most common diagnoses observed in children aged 0‐12 years; hidradenitis suppurativa, folliculitis, and seborrheic dermatitis in adolescents aged 13‐17 years; and folliculitis, seborrheic dermatitis, and xerosis in adults 18 years and older. Other notable diagnoses present overall included onychomycosis (9.9%) and psoriasis (8.9%). Malignant cutaneous tumors were present in two patients, specifically basal cell carcinoma and malignant melanoma in situ.LimitationsThis was a retrospective, single‐institution study.ConclusionDermatologic conditions in patients with Down syndrome vary by age but are most often adnexal and eczematous disorders. Trisomy of chromosome 21 and the resulting downstream effects, specifically on the immune system, may account for these findings.
Fat distribution in short‐stature children born small for gestational age
Authors: Maeyama Takatoshi , Ida Shinobu , Onuma Shinsuke , Shoji Yasuko , Yamamoto Takehisa , Etani Yuri , Kawai Masanobu 
Published: June 2020

AbstractBackgroundChildren born small for gestational age (SGA) with catch‐up growth are at high risk for developing obesity; however, the characteristics of body composition, especially fat distribution, before and after growth hormone (GH) treatment in SGA children without catch‐up growth remains largely unknown.MethodsAnthropometric characteristics, body composition by dual‐energy X‐ray absorption, and fat distribution by computed tomography at the umbilical level were examined in 27 prepubertal short‐stature children born SGA before and 1 year after GH treatment.ResultsBefore GH treatment, short‐stature SGA children had lean phenotypes, and both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were significantly lower than the age‐ and sex‐matched Japanese reference values. Growth hormone treatment significantly increased height standard deviation scores (SDS), without affecting body mass index SDS. Percentage fat mass decreased with GH treatment; however, fat mass was not altered. Both VAT and SAT were significantly lower than the reference values after GH treatment. The ratio of VAT over SAT significantly increased by GH treatment.ConclusionsBoth VAT and SAT were within or below the age‐ and sex‐matched Japanese reference values in short‐stature children born SGA before and after GH treatment, indicating that GH treatment may not have unfavorable effects on adiposity in short‐stature children born SGA, although it may alter fat distribution.
Self‐reported Big Five personality traits of individuals who have experienced partner infidelity
Authors: Mahambrey Meghna 
Published: June 2020

AbstractInfidelity is defined as unapproved romantic or sexual behaviors outside of one's relationship. Previous literature has identified characteristics of the partner involved in infidelity; this study investigates the Big Five personality traits (openness, conscientiousness, extraversion, agreeableness, and neuroticism) of uninvolved partners. Relationship quality and physical intimacy are also examined within a married subsample. Data was drawn from the second wave of the National Survey of Midlife Development in the United States (MIDUS), collected through telephone interviews and self‐administered questionnaires between 2004 and 2006. Results for the overall sample (N = 1,577) indicate that conscientiousness is negatively associated with lifetime partner infidelity. Within the married subsample (n = 898), conscientiousness is negatively associated with spousal infidelity, and agreeableness is positively associated with spousal infidelity.
Ontological disputes and the phenomenon of metalinguistic negotiation: Charting the territory
Authors: Belleri Delia 
Published: June 2020

AbstractParadigmatic cases of ontological disputes are taken to concern whether or not certain objects exist. Some theorists, however, prefer to view ontologists as really debating about what we should mean with the term “exist” (or other cognate terms). This implies interpreting ontological disputes asmetalinguistic negotiations, in keeping with a recent trend to interpret other philosophical disputes along these lines (Plunkett and Sundell.Philosopher's Imprint; 2013;13:1–37). A number of issues arise from such proposal. The first is what counts as evidence that an object‐level dispute isactuallya metalinguistic negotiation. The second regards the dialectical relevance of considering metalinguistic negotiation as even just apossibleinterpretative option. The third issue concerns whether, and why, certain object‐level disputes (and especially ontological ones)should beunderstood as metalinguistic negotiations.
The role of oregano herb and its derivatives as immunomodulators in fish
Authors: Alagawany Mahmoud , Farag Mayada R. , Salah Ayman S. , Mahmoud Mohamed A. 
Published: June 2020

AbstractThe motivation behind this article is to give point‐by‐point data about the beneficial applications of oregano feed supplement in fish diets as immunomodulators, antioxidant, antiviral, antifungal and antiparasitic. Use of this plant as feed additive plays an important role in the fish diet when compared to other synthetic feed additives. Oregano is rich in phytochemical compounds including carvacrol and thymol in addition to other phenolic compounds with antioxidant and immune‐enhancing activities. Origanum vulgare extract improved the immunological responses and enhanced non‐specific immunity. Also, non‐specific immunity and the lysosomal activity were significantly increased in rainbow trout fed diet enriched with 3.0 mL essential oil of Origanum onites L kg−1 diet for 60 days. Furthermore, non‐specific immune stimulant, antioxidant and nitric oxide activities were improved due to O. vulgare oil supplementation. In some recent studies, Origanum heracleoticum L essential oil as a growth enhancer increased the antioxidant status. In rainbow trout, the hepatic levels of antioxidant enzymes and the total antioxidant capacity increased by feeding diet enriched with 6 and 10 g kg−1 diet of O. vulgare extract. Therefore, the addition of oregano and/or derivatives as a dietary supplement in fish diet may promote growth and enhance the immunity and health of fish and this will be useful for nutritionists, physiologists and veterinarians.