bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcellular dynamics of variants of SG2NA in NIH3T3 fibroblasts
Authors: Chauhan Pooja , Gupta Richa , Jain Buddhi P. , Pandey Shweta , Goswami Shyamal K. 
Published: November 2019

AbstractSG2NA, a WD40 repeat protein of the Striatin subfamily, has four splicing and one messenger RNA edit variants. It is fast emerging as a scaffold for multimeric signaling complexes with roles in tissue development and disease. The green fluorescent protein (GFP)‐tagged variants of SG2NA were ectopically expressed in NIH3T3 cells and their modulation by serum and GSK3β‐ERK signaling were monitored. The 87, 78, and 35 kDa variants showed a biphasic modulation by serum till 24 h but the 52 kDa variant remained largely unresponsive. Inhibition of phosphatases by okadaic acid increased the levels of the endogenous 78 kDa and the ectopically expressed GFP‐tagged 87 and 78 kDa SG2NAs. Contrastingly, okadaic acid treatment reduced the level of GFP‐tagged 35 kDa SG2NA, suggesting differential modes of their stability through phosphorylation‐dephosphorylation. The inhibition of GSK3β by LiCl showed a gradual decrease in the levels of 78 kDa. In the case of the other variants viz, GFP‐tagged 35, 52, and 87 kDa, inhibition of GSK3β caused an initial increase followed by a decrease with a subtle difference in kinetics and intensities. Similar results were also seen upon inhibition of GSK3β by small interfering RNA. All the variants showed an increase followed by a decrease upon inhibition of extracellular‐signal‐regulated‐kinase (ERK). These variants are localized in the plasma membrane, endoplasmic reticulum, mitochondria, and the nucleus with different propensities and no discernable subcellular distribution was seen upon stimulation by serum and the inhibition of phosphatases, GSK3β, and ERK. Taken together, the variants of SG2NA are modulated by the kinase‐phosphatase network in a similar but characteristic manner.
Repair of iatrogenic pulmonary vein occlusion with a vascularized atrial flap
Authors: Chemtob Raphaelle A. , Smith Michael , Hatipoglu Umur , Hodges Kevin Edward , Gillinov Alan Marc , Phelan Dermot , Pettersson Gösta Bengt , Wierup Per 
Published: November 2019

AbstractPulmonary vein obstruction is a rare condition, most commonly reported following pulmonary vein catheter ablation for atrial arrhythmia. This novel technique for treatment of pulmonary venous obstruction has the advantage of utilizing an autologous vascularized flap with intact endothelium for reconstruction of the pulmonary vein and to prevent restenosis.
Study of chemical compound spatial distribution in biodegradable active films using NIR hyperspectral imaging and multivariate curve resolution
Authors: Terra Larissa R. , Roque Jussara V. , Pola Cícero C. , Gonçalves Igor M. , Soares Nilda de Fátima F. , Teófilo Reinaldo F. 
Published: November 2019

AbstractA study of spatial distribution of the four different plasticizers and sorbic acid incorporated in cellulose acetate biodegradable films using near‐infrared hyperspectral imaging (NIR‐HSI) and multivariate curve resolution—alternating least squares (MCR‐ALS) is presented. A NIR‐HSI was acquired for each film. MCR‐ALS was applied to generate pure component distribution maps. A repeatability study was performed. The proposed method was able to recover the pure spectra of each film component accurately. The relative concentration vectors obtained by the MCR‐ALS were rebuilt in matrices, and it was possible to analyze the homogeneity of the film constituents based on macropixel analysis and homogeneity index. The NIR‐HSI imaging showed excellent repeatability. For the first time, a study detailing the distribution of chemical compounds incorporated into entire biodegradable films was possible by using NIR hyperspectral imaging combined with the MCR‐ALS method.
The impact of care farms on quality of life, depression and anxiety among different population groups: A systematic review
Authors: Murray Jenni , Wickramasekera Nyantara , Elings Marjolein , Bragg Rachel , Brennan Cathy , Richardson Zoe , Wright Judy , Llorente Marina G. , Cade Janet , Shickle Darren , Tubeuf Sandy , Elsey Helen 
Published: November 2019

AbstractCare farming (also called social farming) is the therapeutic use of agricultural and farming practices. Service users and communities supported through care farming include people with learning disabilities, mental and physical health problems, substance misuse, adult offenders, disaffected youth, socially isolated older people and the long term unemployed. Care farming is growing in popularity, especially around Europe. This review aimed to understand the impact of care farming on quality of life, depression and anxiety, on a range of service user groups. It also aimed to explore and explain the way in which care farming might work for different groups. By reviewing interview studies we found that people valued, among other things, being in contact with each other, and feeling a sense of achievement, fulfilment and belonging. Some groups seemed to appreciate different things indicating that different groups may benefit in different ways but, it is unclear if this is due to a difference in the types of activities or the way in which people take different things from the same activity. We found no evidence that care farms improved people's quality of life and some evidence that they might improve depression and anxiety. Larger studies involving single service user groups and fully validated outcome measures are needed to prove more conclusive evidence about the benefits of care farming.
Split‐sample comparison of urothelial cells in ThinPrep and cytospin preparations in urinary cytology: Do we need to adjust The Paris System for Reporting Urinary Cytology criteria?
Authors: Richardson Christopher J. , Pambuccian Stefan E. , Barkan Güliz A. 
Published: November 2019

BackgroundThe Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear‐to‐cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high‐grade urothelial carcinoma (HGUC). TPS was established using only liquid‐based preparation techniques, and to the authors' knowledge it is unknown whether TPS can be applied using other preparation methods.MethodsIn the current prospective study, voided urine samples from patients with HGUC and negative for HGUC (NHGUC) were prepared using both ThinPrep and cytospin methods. ImageJ image processing software was used to measure the N:C ratio and hyperchromasia. For each patient, the N:C ratio and degree of hyperchromasia of urothelial cells present in both cytopreparations were compared.ResultsA total of 10 HGUC cases and 9 NHGUC cases, represented by a total of 688 cells (mean, 36.7 cells in HGUC cases; and mean, 35.8 cells in NHGUC cases), were evaluated in the current study. An overall comparison of HGUC cells with NHGUC cells demonstrated that HGUC cells had a higher average N:C ratio (0.5465 vs 0.2846) and greater hyperchromasia as measured by the average nuclear pixel gray value (100.8 vs 120.7). The N:C ratio was statistically different in 4 NHGUC cases, demonstrating higher N:C ratios in the ThinPrep preparations. Hyperchromasia was found to be statistically different in 6 cases, 5 of which demonstrated increased hyperchromasia in the ThinPrep specimens.ConclusionsThe morphologic features of HGUC cells appear to be similar in samples prepared using the ThinPrep and cytospin methods, and therefore TPS criteria may be applied successfully in laboratories that use these methods.
An improvement mechanism for heartbeat‐driven MAC synchronization in wireless body sensor network
Authors: Wu Tin‐Yu , Wang Wei 
Published: November 2019

SummaryThis paper aims to improve the TDMA‐based Heartbeat‐Driven MAC (H‐MAC) protocol for WBAN. H‐MAC is designed to be used in star‐topology WBAN for time synchronization realization by using heartbeat rhythm information, instead of periodic synchronization beacons. H‐MAC therefore saves power of WBAN sensor nodes and reduces the negative effects of electromagnetic radiation on human health during the packet delivery process. To embed heartbeat rhythm information into different bio‐signals and check the peak values of wave forms can contribute to time synchronization for BSN. As the heart contracts via systole and relaxes via diastole, pulse is the number of times one's heart beats every minute and the number of pulses measured at different body parts is the same. However, blood vessels run over the whole human body and their distances away from the heart greatly vary in the same systole, leading to an imperceptible time difference and the synchronization problem. We propose to include the presently most mature method for time synchronization, Flooding Time Synchronization Protocol (FTSP), to deal with time differences.
Regulation of auxin transcriptional responses
Authors: Powers Samantha K. , Strader Lucia C. 
Published: November 2019

AbstractThe plant hormone auxin acts as a signaling molecule to regulate a vast number of developmental responses throughout all stages of plant growth. Tight control and coordination of auxin signaling is required for the generation of specific auxin‐response outputs. The nuclear auxin signaling pathway controls auxin‐responsive gene transcription through the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F‐BOX pathway. Recent work has uncovered important details into how regulation of auxin signaling components can generate unique and specific responses to determine auxin outputs. In this review, we discuss what is known about the core auxin signaling components and explore mechanisms important for regulating auxin response specificity.
Chemical‐Free Approach for Z‐Isomerization of Lycopene in Tomato Powder: Hot Air and Superheated Steam Heating above the Melting Point of Lycopene
Authors: Honda Masaki , Kageyama Hakuto , Hibino Takashi , Waditee‐Sirisattha Rungaroon , Fukaya Tetsuya , Hayashi Yoshiaki , Goto Motonobu 
Published: November 2019

AbstractZ‐isomers of lycopene exhibit higher bioavailability and antioxidant capacity than those of the all‐E‐isomer. Therefore, it is important to develop an efficient and environmentally friendly procedure for Z‐isomerization. The current methods for Z‐isomerization of (all‐E)‐lycopene use toxic chemicals such as organic solvents and catalysts. This study is aimed to develop a chemical‐free method for Z‐isomerization of (all‐E)‐lycopene in tomato powder by hot air and superheated steam heating. The Z‐isomerization reaction is promoted by heating above the melting point of lycopene. When heated with superheated steam, the thermal decomposition of lycopene is suppressed compared to that when heated with hot air. When tomato powder is heated at 240 °C for 5 min by superheated steam, the total Z‐isomer content and remaining lycopene are 69.0% and 90.7%, respectively, while with hot air heating, the total Z‐isomer content and remaining lycopene are 69.9% and 68.0%, respectively. These results indicate that the thermal Z‐isomerization of lycopene occurs in the molten state and heating in a low oxygen atmosphere suppresses the thermal decomposition of lycopene.Practical Applications: Tomato powder rich in lycopene Z‐isomers is an important ingredient for the food and animal feed industries. Since Z‐isomers of lycopene are more soluble in solvents including ethanol which is a low‐toxicity and environmentally friendly solvent, the efficiency of lycopene extraction with ethanol can be improved by using the Z‐isomer‐rich tomato powder as a raw material. The obtained Z‐isomer‐rich extract has a high added value because the Z‐isomers have higher bioavailability and antioxidant capacity than those of the all‐E‐isomer. In addition, since lycopene Z‐isomers exhibit higher accumulation efficiency and better color improvement in hen egg yolks than those of the all‐E‐isomer, Z‐isomer‐rich tomato powder is an effective animal feed.
Application of flotation column for Cl‐ and N, N′‐bis (2‐hydroxyethyl) piperazine separation in gas sweetening unit
Authors: Haddad Javid , Manteghian Mehrdad 
Published: November 2019

The degradation of amine solvents leads to increasing costs and deterioration in long term performance. Therefore, the purification of the solvents is needed to guarantee smoother operations. In this research, the flotation setup was investigated by means of laboratory and pilot‐scale experiments in the amine reclamation for chloride and N, N′‐bis (2‐hydroxyethyl) piperazine (BHEP) separation. The maximum removal efficiency recorded was 51% for the largest chloride concentration of 7091 mg/l and 37% for the lowest chloride concentration of 1536 mg/l. The mass transfer coefficient was hence correlated with the hydrodynamic parameters, including chloride reduction rate, bubble surface area, and gas and liquid phase concentration. The average chloride removal efficiency for the monoethanolamine (MEA) was more than 61% due to a better dispersion of pure nitrogen gas bubbles and formation of the tiny bubbles provided in the column. The results indicated that a higher chloride initial concentration corresponded to better performance of the setup. Under the typical column operating conditions, it was concluded that a collection zone H:D of 10:1 was a reasonable compromise. The flotation setup results in BHEP separation, known as amine degradation product showed about 24% average amine recovery.
Effect of shearing on hydraulic properties of rough‐walled fractures under different boundary conditions
Authors: Wang Changsheng , Jiang Yujing , Luan Hengjie , Sugimoto Satoshi 
Published: November 2019

AbstractThis study experimentally investigated nonlinear flow characteristics of rough‐walled fractures during shear process under different boundary conditions, using the servo‐controlled shear‐flow apparatus. A series of shear‐flow tests were conducted on two types of rough fractures with different shear displacements under various boundary conditions. The effects of shear process, fracture surface roughness, boundary normal stiffness, and initial normal stress on nonlinear flow behaviors are analyzed. The results show that Forchheimer equation provides a good description of the nonlinear relationship between flow rate and pressure gradient in rough‐walled fractures. The linear and nonlinear coefficients decrease by 1‐2 and 2‐3 orders of magnitude during shear, respectively. Both the mechanical aperture and the hydraulic aperture increase with increasing shear displacement. The mechanical aperture is always larger than the hydraulic aperture, and their difference gradually increases with the increment of shear displacement. The contact area ratio exhibits a fast decrease as shear displacement ranges between 1 and 3 mm and then decreases gradually with the decreasing rate generally diminishes. With the increase in shear displacement, the critical Reynolds number shows an increasing trend. The critical Reynolds number is in range 3.22‐35.41 for fracture G1 and 1.23‐12.35 for fracture G3. As the boundary normal stiffness and initial normal stress increase, the critical Reynolds number decreases.
Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality
Authors: Kashyap Rajan , Bhattacharjee Sagarika , Yeo B. T. Thomas , Chen S. H. Annabel 
Published: November 2019

AbstractPatterns in resting‐state fMRI (rs‐fMRI) are widely used to characterize the trait effects of brain function. In this aspect, multiple rs‐fMRI scans from single subjects can provide interesting clues about the rs‐fMRI patterns, though scan‐to‐scan variability pose challenges. Therefore, rs‐fMRI's are either concatenated or the functional connectivity is averaged. This leads to loss of information. Here, we use an alternative way to extract the rs‐fMRI features that are common across all the scans by applying common‐and‐orthogonal‐basis‐extraction (COBE) technique. To address this, we employed rs‐fMRI of 788 subjects from the human connectome project and estimated the common‐COBE‐component of each subject from the four rs‐fMRI runs. Since the common‐COBE‐component is specific to a subject, the pattern was used to classify the subjects based on the similarity/dissimilarity of the features. The subset of subjects (n = 107) with maximal‐COBE‐dissimilarity (MCD) was extracted and the remaining subjects (n = 681) formed the COBE‐similarity (CS) group. The distribution of weights of the common‐COBE‐component for the two groups across rs‐fMRI networks and subcortical regions was evaluated. We found the weights in the default mode network to be lower in the MCD compared to the CS. We compared the scores of 69 behavioral measures and found six behaviors related to the use of marijuana, illicit drugs, alcohol, and tobacco; and including a measure of antisocial personality to differentiate the two groups. Gender differences were also significant. Altogether the findings suggested that subtypes exist even in healthy control population, and comparison studies (case vs. control) need to be mindful of it.
Replicable brain signatures of emotional bias and memory based on diffusion kurtosis imaging of white matter tracts
Authors: Welton Thomas , Indja Ben E. , Maller Jerome J. , Fanning Jonathon P. , Vallely Michael P. , Grieve Stuart M. 
Published: November 2019

AbstractDiffusion MRI (dMRI) is sensitive to anisotropic diffusion within bundles of nerve axons and can be used to make objective measurements of brain networks. Many brain disorders are now recognised as being caused by network dysfunction or are secondarily associated with changes in networks. There is therefore great potential in using dMRI measures that reflect network integrity as a future clinical tool to help manage these conditions. Here, we used dMRI to identify replicable, robust and objective markers that meaningfully reflect cognitive and emotional performance. Using diffusion kurtosis analysis and a battery of cognitive and emotional tests, we demonstrated strong relationships between white matter structure across networks of anatomically and functionally specific brain regions with both emotional bias and emotional memory performance in a large healthy cohort. When the connectivity of these regions was examined using diffusion tractography, the terminations of the identified tracts overlapped precisely with cortical loci relating to these domains, drawn from an independent spatial meta‐analysis of available functional neuroimaging literature. The association with emotional bias was then replicated using an independently acquired healthy cohort drawn from the Human Connectome Project. These results demonstrate that, even in healthy individuals, white matter dMRI structural features underpin important cognitive and emotional functions. Our robust cross‐correlation and replication supports the potential of structural brain biomarkers from diffusion kurtosis MRI to characterise early neurological changes and risk in individuals with a reduced threshold for cognitive dysfunction, with further testing required to demonstrate clinical utility.
The impact of medical insurance programmes on the health of the insured: Evidence from China
Authors: Meng Yingying , Zhang Xiaodong , Han Junqiang 
Published: November 2019

SummaryThe impact of medical insurance on the health of the insured has long been an issue of major concern within academia. From the beginning of the 21st century, the Chinese government has invested a large amount of money in national medical insurance programmes. China's current national medical insurance system consists of three types of programmes: basic medical insurance for urban employees (BMIUE), basic medical insurance for urban and rural residents (BMIURR), and public medical insurance (PMI). These three types of medical insurance have significant differences in terms of premiums, policy deductibles, and levels of coinsurance, thus providing us with the opportunity to study the different impacts these programmes have on their covered members. Based on the 2016 China Family Panel Studies (CFPS) conducted by the China Social Science Research Centre in Peking University, this paper applies the ordered probit model to study the various impacts of these three programmes on the insured under each plan. The study found that compared with citizens who are not enrolled in any insurance programme, citizens who are covered by one of the three programmes report better health; compared with those covered by the BMIUE and BMIURR plans, members covered under the PMI programme report significantly better health; and after controlling for the adverse selection of participants in either the BMIUE or BMIURR plan, citizens who are enrolled in the BMIUE programme have a higher utilization rate of medical resources and report better health than those enrolled in the BMIURR plan.
Risk contagion in the cross‐border banking network: Some new evidence
Authors: Chen Bing , Li Li , Peng Fei , Salim Ruhul 
Published: November 2019

AbstractThis paper applies consolidated banking statistics data from the Bank for International Settlement to simulate risk contagion in a cross‐border banking system with shocks of credit and liquidity. Simulation results from balance sheet network analysis show that the banking systems of the United States and United Kingdom are the most systemically important systems under the credit shocks in June 2008. Moreover, banking system's counter‐shocks ability is directly related to its size and concentration of foreign claims. The banking systems of German and French are the most systemically important systems under the liquidity shocks. Some banking systems depend heavily on German and French banking systems for financing and are vulnerable to liquidity shocks. Risk transfer has influence on risk contagion in the cross‐border banking system. After the subprime crisis, cross‐border risk contagion has declined because of deleveraging foreign claims. Raising the capital level of the banking system or intervention in the interbank market to enhance the liquidity of the market under pressure scenarios can reduce the contagion effect of credit or liquidity shocks.
Early detection of cancerous tissues in human breast utilizing near field microwave holography
Authors: Kumari Vineeta , Ahmed Aijaz , Kanumuri Tirupathiraju , Shakher Chandra , Sheoran Gyanendra 
Published: November 2019

AbstractThis work demonstrates an application of near field indirect microwave holography for the detection of malignant tissues in human breast in an effective way. The holograms are recorded by two directive antennas aligned along each other's boresight while performing a raster scan over a 2D plane utilizing XY‐linear motorized translation stage and a uniform reference wave. The whole information that is, amplitude and phase of an object has been provided by indirect holography at microwave frequencies. The extracted phase values are used to determine the dielectric permittivity values which are further utilized for the identification and validating the positions of malignant tissues in the breast phantom. The experimental evaluations performed on the in‐house designed and developed tissue mimicking 3D printed breast phantoms. The experimental results demonstrate the ability of microwave holography using directive antennas in detecting and identifying the tumors upto the minimum size of 4 mm and maximum depth of 25 mm in fabricated phantom. The quantitative results present the potential of the Near Field Indirect Holographic Imaging (NFIHI) in order to develop an efficient and economical tool for breast cancer detection.