bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expert consensus on clinical applications of high-frequency oscillations in epilepsy
Authors: Wang Yuping , Zhou Dong , Yang Xiaofeng , Xu Xin , Ren Liankun , Yu Tao , Zhou Wenjing , Shao Xiaoqiu , Yang Zhixian , Wang Shuang , Cao Dezhi , Liu Chunyan , Kwan Shang Yeong , Xiang Jing 
Published: June 2020

AbstractStudies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis. This consensus includes the definition and standard detection techniques of HFOs, the localizing value of pathological HFOs for epileptic foci, and different ways to distinguish physiological from epileptic HFOs. The latest clinical applications of HFOs in epilepsy and the related findings are also discussed. HFOs will advance our understanding of the pathophysiology of epilepsy.
Pore structure and controlling factors of dolomite-bearing high-salinity shale reservoir in Qianjiang Formation, Jianghan Basin, China
Authors: Zhou Tong , Su Jianzheng , Fan Shichao , Li Zhaofeng , Liu Xiaoxue , Tang Xianglu 
Published: June 2020

High-salinity shale is a unique and promising shale-oil reservoir in continental basins. We have collected representative samples from different lithologies from wells in the Qianjiang Depression to test the pore structure and basic character from prospective high-salinity oil-bearing shales. We conducted field emission scanning electron microscopy and X-ray diffraction analyses to study the high-salinity shale pore morphology and composition, respectively. We used mercury injection capillary pressure to understand the high-salinity shale macropore distribution, and we used low-pressure nitrogen (N2) adsorption to study the mesopore distribution. The results show that the high-salinity shale-oil reservoir mainly is composed of carbonate (dolomite and calcite), clay, and saline minerals (anhydrite, glauberite, and halite). Many intergranular pores were developed in the high-salinity shale. The mesopores and macropores both were developed well in argillaceous dolomite. The average pore volume of macropores is 0.0588 ml/g, which accounts for approximately 59% of the total pore volume. Therefore, in the high-salinity shale-oil reservoirs that we tested, macropores were more important than other pores. The symbiosis of dolomite and calcite improved the porosity of the high-salinity shale-oil reservoir, and the salt minerals increased the pore complexity.
A method to compensate for migration stretch to improve the resolution of amplitude variation with offset, S-impedance (ZS), and density (ρ)
Authors: Patel Swetal , Oyebanji Francis , Marfurt Kurt J. 
Published: June 2020

Because of their improved leverage against ground roll and multiples, as well as the ability to estimate azimuthal anisotropy, wide-azimuth 3D seismic surveys routinely now are acquired over most resource plays. For a relatively shallow target, most of these surveys can be considered to be long offset as well, containing incident angles up to 45°. Unfortunately, effective use of the far-offset data often is compromised by noise and normal moveout (NMO) (or, more accurately, prestack migration) stretch. The conventional NMO correction is well-known to decrease the frequency content and distort the seismic wavelet at far offsets, sometimes giving rise to tuning effects. Most quantitative interpreters work with prestack migrated gathers rather than unmigrated NMO-corrected gathers. However, prestack migration of flat reflectors suffers from the same limitation called migration stretch. Migration stretch leads to lower S-impedance ([Formula: see text]) and density ([Formula: see text]) resolution estimated from inversion, misclassification of amplitude variation with offset (AVO) types, and infidelity in amplitude variation with azimuth (AVAZ) inversion results. We have developed a matching pursuit algorithm commonly used in spectral decomposition to correct the migration stretch by scaling the stretched wavelets using a wavelet compensation factor. The method is based on hyperbolic moveout approximation. The corrected gathers show increased resolution and higher fidelity amplitudes at the far offsets leading to improvement in AVO classification. Correction for migration stretch rather than conventional “stretch-mute” corrections provides three advantages: (1) preservation of far angles required for accurate [Formula: see text] inversion, (2) improvement in the vertical resolution of [Formula: see text] and [Formula: see text] volumes, and (3) preservation of far angles that provide greater leverage against multiples. We apply our workflow to data acquired in the Fort Worth Basin and retain incident angles up to 42° at the Barnett Shale target. Comparing [Formula: see text], [Formula: see text], and [Formula: see text] of the original gather and migration stretch-compensated data, we find an insignificant improvement in [Formula: see text], but a moderate to significant improvement in resolution of [Formula: see text] and [Formula: see text]. The method is valid for reservoirs that exhibit a dip of no more than 2°. Consistent improvement is observed in resolving thick beds, but the method might introduce amplitude anomalies at far offsets for tuning beds.
Seismic response to paleo-sand dunes in the Nugget Sandstone Formation, southwestern Wyoming
Authors: Agrawal Dhruv , Lujan Brady , Verma Sumit , Bhattacharya Shuvajit , Mallick Subhashis 
Published: June 2020

We have analyzed a 3D seismic survey acquired for a carbon sequestration project on top of the Moxa Arch in southwestern Wyoming. We observed a zone of discontinuous reflectors on vertical slices of seismic amplitude volume, whereas, the northwest–southeast lineations were observed on the time slices. We performed a seismic to well tie that suggested that the lineations occur within the Nugget Sandstone. The Nugget Sandstone is an eolian sandstone deposit of Early Jurassic age, deposited as a subtropical dune field, and equivalent to the Navajo Sandstone of southwestern Utah. Petrophysical analysis indicates that the Nugget Sandstone is dominated by clean sandstone (70%–80%), whereas evaporites, including halite and anhydrite, are present in certain zones. Previous outcrop studies on the Navajo Sandstone indicate the wind direction to be predominantly northeast–southwest. Seismic attributes, including coherence and curvature, displayed on stratal slices within the Nugget Sandstone interval indicate the presence of lineations in the northwest–southeast direction with irregular spacing. These lineations are approximately perpendicular to the inferred dominant wind direction. We computed the dominant wind direction from the average azimuth of the lineations as seen on the curvature attribute in the Nugget Sandstone interval. Geological feature: Eolian sand dunes with interdunal evaporites Seismic appearance: Parallel lineations with irregular spacing on seismic attribute horizon slices Alternative interpretations: Canyons at continental slopes; slope failures Features with a similar appearance: Marine bars; contourites Formation: The Nugget Sandstone — equivalent to the Navajo Sandstone Age: Early Jurassic Location: Moxa Arch, Wyoming Seismic data: Obtained by the University of Wyoming with U.S. DOE funding Contributors: Dhruv Agrawal, Brady Lujan, Sumit Verma, Shuvajit Bhattacharya, and Subhashis Mallick Analysis tools: Coherence and curvature attributes; seismic inversion; petrophysical inversion
Seismic attributes and analogs to characterize a large fold in the Taranaki Basin
Authors: La Marca Molina Karelia , Bedle Heather , Tellez Jerson 
Published: June 2020

The Taranaki Basin lies in the western portion of New Zealand, onshore and offshore. It is a Cretaceous rift basin that is filled with up to approximately 10 km thick deposits from marine to deepwater depositional environments from the Cretaceous (approximately 93 ma) to the Neogene (approximately 15 ma). This basin underwent important tectonic events that resulted in large-scale features such as faults and folds and the deposition of turbidites such as channels and channel belts. These features easily are recognizable in seismic data. When analyzing the offshore 3D Pipeline data set, we recognized a peculiar fault-like feature with large-scale dimensions (approximately 15 km long and approximately 1 km wide) within the sequence. The alignment was perpendicular to the direction of deposition in the basin (southeast–northwest) as identified by previous studies and subparallel to the main structures in the area (southwest–northeast). We interpreted the seismic character of the funny-looking thing (FLT) likely as (1) a fault, (2) a fold, or (3) a large channel belt within the basin. We use seismic attributes such as coherence (Sobel filter), dip, cosine of phase, and curvature to characterize this feature geomorphologically. The geologic background of the area and analog settings aided in understanding and distinguishing the nature of this large structure. Monocline examples in seismic data are rare to find, and we want to show how to avoid misinterpretations. Geological feature: Fault-bend fold or large-amplitude fold (possibly monocline) Seismic appearance: Large, discontinuous, high-variance feature Alternative interpretations: Fault, fold Features with a similar appearance: Fault, fold, wide straight channel belt (time or horizon slice) Formation: Rift sequence of the Taranaki Basin Age: Eocene Location: Taranaki Basin, Western offshore New Zealand Seismic data: Provided by New Zealand Petroleum and Minerals Contributors: Karelia La Marca, Heather Bedle, Jerson Tellez; School of Geosciences; University of Oklahoma, Norman, OK, USA Analysis tool: 3D reflection seismic, geometric seismic attributes
Systematic Review of Modern Case Series of Squamous Cell Cancer Arising in a Chronic Ulcer (Marjolin's Ulcer) of the Skin
Authors: Abdi Mohamed A. , Yan Michael , Hanna Timothy P. 
Published: June 2020

PURPOSE Marjolin's ulcer is an aggressive cutaneous malignancy that arises in chronic nonhealing wounds. A review of modern series describing Marjolin's ulcer would be helpful in defining optimal management strategies and expected outcomes. METHODS A systematic review was performed on October 18, 2018, by querying Medline and EMBASE. Key inclusion criteria were as follows: human studies, English language, published in 2000 or later, > 10 patients, and at least 80% of the patients having squamous cell carcinoma (SCC) histology. RESULTS There were 599 patients in 14 case series from 10 countries; 82% of patients were from low-income and middle-income countries, and 48% were women. Overall, 65% of the ulcers were preceded by burns. Mean latency ranged from 11 years to 41 years (median, 28 years). Lower extremities were the most common site (62%). Differentiation was reported as well differentiated (64%), moderately differentiated (27%), or poorly differentiated (9%). Almost one third of cases were clinically node positive, though only 7% of all cases (24 of 334) were confirmed to be pathologically involved. Distant metastasis rates were reported in only 7 series, with median rate of 5% (range, 0%-27%). The main treatment modality was surgical excision (71%), followed by amputation (24%), primary radiotherapy (2%), and chemotherapy (< 1%). Outcomes data varied in content and quality. Mortality rates were 12%, 24%, and 37% in the three series reporting between 2 and 3 years of follow-up. CONCLUSION Marjolin's ulcer with SCC histology is an aggressive cancer with a notable potential for lymph node metastasis and distant metastasis. Comprehensive staging is recommended, with management optimally having a multidisciplinary context. Low- and middle-income countries are overrepresented in reports of Marjolin’s ulcer, and there may be opportunities for prevention and early detection.
Improved Risk Prediction Calculator for Sentinel Node Positivity in Patients With Melanoma: The Melanoma Institute Australia Nomogram
Authors: Lo Serigne N. , Ma Jiawen , Scolyer Richard A. , Haydu Lauren E. , Stretch Jonathan R. , Saw Robyn P. M. , Nieweg Omgo E. , Shannon Kerwin F. , Spillane Andrew J. , Ch’ng Sydney , Mann Graham J. , Gershenwald Jeffrey E. , Thompson John F. , Varey Alexander H. R. 
Published: June 2020

PURPOSE For patients with primary cutaneous melanoma, the risk of sentinel node (SN) metastasis varies according to several clinicopathologic parameters. Patient selection for SN biopsy can be assisted by National Comprehensive Cancer Network (NCCN) and ASCO/Society of Surgical Oncology (SSO) guidelines and the Memorial Sloan Kettering Cancer Center (MSKCC) online nomogram. We sought to develop an improved online risk calculator using alternative clinicopathologic parameters to more accurately predict SN positivity. PATIENTS AND METHODS Data from 3,477 patients with melanoma who underwent SN biopsy at Melanoma Institute Australia (MIA) were analyzed. A new nomogram was developed by replacing body site and Clark level from the MSKCC model with mitotic rate, melanoma subtype, and lymphovascular invasion. The predictive performance of the new nomogram was externally validated using data from The University of Texas MD Anderson Cancer Center (n = 3,496). RESULTS The MSKCC model receiver operating characteristic curve had a predictive accuracy of 67.7% (95% CI, 65.3% to 70.0%). The MIA model had a predictive accuracy of 73.9% (95% CI, 71.9% to 75.9%), a 9.2% increase in accuracy over the MSKCC model ( P < .001). Among the 2,748 SN-negative patients, SN biopsy would not have been offered to 22.1%, 13.4%, and 12.4% based on the MIA model, the MSKCC model, and NCCN or ASCO/SSO criteria, respectively. External validation generated a C-statistic of 75.0% (95% CI, 73.2% to 76.7%). CONCLUSION A robust nomogram was developed that more accurately estimates the risk of SN positivity in patients with melanoma than currently available methods. The model only requires the input of 6 widely available clinicopathologic parameters. Importantly, the number of patients undergoing unnecessary SN biopsy would be significantly reduced compared with use of the MSKCC nomogram or the NCCN or ASCO/SSO guidelines, without losing sensitivity. An online calculator is available at www.melanomarisk.org.au .
Developing laboratory capacity for Good Laboratory Practice certification: lessons from a Tanzanian insecticide testing facility
Authors: Begg Sara , Wright Alexandra , Small Graham , Mosha Franklin , Kirby Matthew , Snetselaar Janneke , Aziz Salum , Bharmal Jameel , Dacombe Russell , Bates Imelda 
Published: June 2020

Background:With increasing insecticide resistance in malaria-endemic countries there is an urgent need for safe and effective novel vector control products. To improve the capacity of facilities that test insecticides in sub-Saharan Africa, a programme is supporting seven facilities towards Good Laboratory Practice (GLP) certification, the globally recognized standard for quality management system (QMS) for the conduct of non-clinical and environmental studies. The World Health Organization (WHO) GLP Handbook provides guidance on a stepwise approach to implement a GLP compliant QMS. This study assesses auditor GLP checklists and timings outlined in the WHO GLP Handbook in the real-life context of a Tanzanian insecticide-testing facility, evaluating their implementation in this context.Methods and Principle Findings:We conducted document review and semi-structured interviews with staff at all levels of the test facility to explore factors that influenced progress towards GLP certification. We found that while auditor GLP checklists underemphasised computer systems, they were otherwise broadly applicable. Factors that delayed time to completion of GLP certification included the need for extensive infrastructure improvements, the availability of regional expertise related to GLP, the capacity of national and regional external systems and services to meet GLP compliance requirements, and training development required for Standard Operating Procedure implementation.Conclusion:The standards required for full GLP compliance are rigorous, with an expected completion timeline to implementation of 24 months. This study shows that in low and middle-income countries this timeline may be unrealistic due to challenges related to infrastructure development and lack of regional capacity and expertise. We recommend a comprehensive gap analysis when starting a project, including these areas which are beyond those recommended by the WHO GLP Handbook. These challenges can be successfully overcome and the experience in Tanzania provides key lessons for other facilities seeking GLP certification or the development of similar QMS.
A multi centre randomized open label trial of chloroquine for the treatment of adults with SARS-CoV-2 infection in Vietnam
Authors: Kestelyn Evelyne , Dung Nguyen Thi Phuong , Lam Minh Yen , Hung Le Manh , Quan Nguyen Minh , Dung Nguyen Thanh , Minh Ngo Ngoc Quang , Xuan Tran Chanh , Phong Nguyen Thanh , Ninh Thi Thanh Van , Donovan Joseph , Tu Tran Nguyen Hoang , Nhat Le Thanh Hoang , Truong Nguyen Thanh , Man Dinh Nguyen Huy , Thao Huynh Phuong , Ngoc Nghiêm My , Lam Vo Thanh , Phat Huynh Hong , Phuong Phan Minh , Geskus Ronald B. , Ha Vo Thi Nhi , Quang Nguyen Ngo , Tran Tinh Hien , Tan Le Van , Thwaites Guy E. , Day Jeremy N. , Chau Nguyen Van Vinh ,   OUCRU COVID-19 Research Group
Published: June 2020

Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent COVID-19 or therapeutic agent to treat COVID-19. This clinical trial is designed to evaluate chloroquine as a potential therapeutic for the treatment of hospitalised people with COVID-19. We hypothesise that chloroquine slows viral replication in patients with COVID-19, attenuating the infection, and resulting in more rapid decline of viral load in throat/nose swabs. This viral attenuation should be associated with improved patient outcomes. Method: The study will start with a 10-patient prospective observational pilot study following the same entry and exclusion criteria as for the randomized trial and undergoing the same procedures. The main study is an open label, randomised, controlled trial with two parallel arms of standard of care (control arm) versus standard of care with 10 days of chloroquine (intervention arm) with a loading dose over the first 24 hours, followed by 300mg base orally once daily for nine days. The study will recruit patients in three sites in Ho Chi Minh City, Vietnam: the Hospital for Tropical Diseases, the Cu Chi Field Hospital, and the Can Gio COVID hospital. The primary endpoint is the time to viral clearance from throat/nose swab, defined as the time following randomization until the midpoint between the last positive and the first of the negative throat/nose swabs. Viral presence will be determined using RT-PCR to detect SARS-CoV-2 RNA. Discussion: The results of the study will add to the evidence-based guidelines for management of COVID-19. Given the enormous experience of its use in malaria chemoprophylaxis, excellent safety and tolerability profile, and its very low cost, if proved effective then chloroquine would be a readily deployable and affordable treatment for patients with COVID-19. Trial registration: Clinicaltrials.gov NCT04328493 31/03/2020
Precision in a Seller’s Market: Round Asking Prices Lead to Higher Counteroffers and Selling Prices
Authors: Leib Margarita , Köbis Nils C. , Francke Marc , Shalvi Shaul , Roskes Marieke 
Published: June 2020

Precise, compared with round, asking prices lead to counteroffers and final agreements that are closer to the asking price. Consequently, popular advice for sellers is to set precise asking prices. We propose that the advice is useful, but only in a buyer’s market, in which buyers counter below the asking price. In a seller’s market, in which buyers counter above the asking price, sellers who wish to receive high counteroffers and sell for high prices should set round asking prices. A preregistered study (n = 1,809) shows that, compared with round asking prices, precise prices lead to higher counteroffers in a buyer’s market but to lower counteroffers in a seller’s market. The effect is driven by buyers’ use of a finer-grained pricing scale when countering precise asking prices. An analysis of transactions (n = 8,278) from Amsterdam’s 2017 real estate market, in which 70% of the properties were sold above the asking price, corroborates the experimental findings. Results show that increasing the roundness of the asking price by one decimal, for instance, from precise to the thousands to precise to the tens of thousands, was associated with an increase of 0.6% in the selling price, equivalent to €2,099 on average. This paper was accepted by Yuval Rottenstreich, decision analysis.
Treatment of 52 patients with a self-adhesive siliconised superabsorbent dressing: a multicentre observational study
Authors: Barrett Simon , Rippon Mark , Rogers Alan A. 
Published: June 2020

Objective: To provide ‘in use’ clinical data to support exudate management in patients with moderately to highly exuding wounds with bordered superabsorbent wound dressing with a silicone adhesive interface. Method: This study was an open-labelled non-comparative study. Patients included in the study were selected by the clinical investigator(s) according to whether the patient required a dressing for the management of moderately to highly exuding wounds. Results: The primary aim of this study was to evaluate the clinical objective in relation to exudate handling (moderate to high) with a superabsorbent silicone border dressing (Zetuvit Plus Silicone Border; SAP silicone border dressing; designated RespoSorb Silicone Border in some countries). The SAP border dressing had met the clinical objectives relating to exudate management, affirmed by the health professionals with a yes response in 94% of cases. Additionally, the health professionals rated the handling of exudate as excellent/good (78%) and most (80%) reported that they would use the SAP silicone border dressing again. Allied to this was the fact that the SAP silicone border dressing improved the wound edge and periwound skin conditions (29% and 36% of patients, respectively). Regarding dressing retention, the SAP silicone border dressing retained its position in 72% of patients. For wear time, the largest proportion of dressing changes, both pre-study and during the evaluation period, was every third day (45% and 44%, respectively). But there was a shift to extended wear time with use of the SAP silicone border dressing with 72% of patients' dressing changes being every third day or longer. Conclusion: The SAP silicone border dressing was successful in managing wound exudate in moderately to highly exuding wounds and consequently this had a beneficial impact on the wound edge and periwound skin. Overall, there was a positive effect on wound bed preparation and in turn the healing response was progressive. This study has shown that the SAP silicone border dressing successfully controlled exudate and provided positive benefits when used in the treatment of patients with moderately to highly exuding wounds.