bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can urinary CTX-II be a biomarker for knee osteoarthritis?
Authors: Arunrukthavon Piti , Heebthamai Danai , Benchasiriluck Prapasri , Chaluay Supinda , Chotanaphuti Thanainit , Khuangsirikul Saradej 
Published: February 2020

Abstract
Background
Early diagnosis of knee osteoarthritis (OA) remains a diagnostic challenge. Urinary C-terminal cross-linked telopeptide of type II collagen (urinary CTX-II) is one of the potential OA biomarkers. However, conclusive evidence regarding the use of this biomarker as a tool for early diagnosis is still lacking. The purposes of this study were to compare urinary CTX-II levels in patients with knee OA and in healthy controls, to evaluate the correlation between urinary CTX-II levels, radiographic severity of OA, and patient-reported outcomes and to evaluate the effect of age and gender on urinary CTX-II levels in the Asian populations.

Methods
Two groups were studied. The OA group included 78 patients with knee OA aged > 40 years who met the diagnostic criteria for knee OA described by the American College of Rheumatology (ACR). The control group consisted of 51 healthy participants age > 40 years without clinical or radiographic evidence of knee OA. Bilateral knee radiographs were taken and classified according to the Kellgren and Lawrence (KL) grading system. Urinary CTX-II was measured using a competitive ELISA test and Western Ontario and Mcmaster Universities Arthritis Index (WOMAC) was also recorded in all participants.

Results
Urinary CTX-II was significantly higher in the OA group than in the control group (p < 0.001). The severe knee OA group (KL grade 3 and 4) had higher urinary CTX-II levels than mild knee OA group (KL grade 2) but the difference did not reach statistical significance (p = 0.2). There was a moderate correlation between urinary CTX-II levels and KL grades (r = 0.405, p < 0.001) and a weak correlation between urinary CTX-II levels and WOMAC index scores (r = 0.367, p < 0.001). Multiple regression analysis showed that urinary CTX-II was independently associated with KL grades. Whereas age, gender, and WOMAC index had no statistically significant influence on the urinary CTX-II levels.

Conclusions
Patients with knee OA had higher urinary CTX-II levels than healthy controls. Moreover, levels of urinary CTX-II were independently correlated with radiographic severity of knee OA. Age, gender, and patient-reported outcomes exerted no effect on the urinary CTX-II levels.

Level of evidence
Diagnostic Level III.
Modeling and data-driven isolation of two-way wavefield constituents
Authors: Elison Patrick , Börsing Nele , van Manen Dirk-Jan , Robertsson Johan O. A. 
Published: February 2020

Synthesizing individual wavefield constituents (such as primaries, first-order scattering, and free-surface or internal multiples) is important in the development of seismic data processing algorithms, for instance, for seismic multiple removal and imaging. A range of methods that allow for the computation of such wavefield constituents exist, but they are generally restricted to relatively simple, horizontally layered media. For wave simulations on more complex models, a straightforward and performant alternative are finite-difference methods. They are, however, generally not perceived as being capable of delivering isolated wavefield constituents. Based on recent advances, we found how this can be achieved for (nonhorizontally) piecewise constant layered media. For example, we were able to accurately retrieve the isolated direct arrival of the transmission response (including tunneled waves), primary reflection data (without internal multiples), and all events related to a single (or multiple) interface(s) in a medium. Our methods required detailed knowledge of discretized medium parameters. Alternatively, if a medium is known only implicitly via recordings of reflection data, interface-related events can still be isolated through a combination of subdomain-related wavefields. We found how Marchenko redatuming can be used to derive these, which enables data-driven identification (and removal) of interface-related events from surface data.
The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation
Authors: Galeano Niño Jorge Luis , Tay Szun S. , Tearle Jacqueline L. E. , Xie Jianling , Govendir Matt A. , Kempe Daryan , Mazalo Jessica , Drew Alexander P. , Colakoglu Feyza , Kummerfeld Sarah K. , Proud Christopher G. , Biro Maté 
Published: February 2020

ABSTRACT
It has become increasingly evident that T cell functions are subject to translational control in addition to transcriptional regulation. Here, by using live imaging of CD8+ T cells isolated from the Lifeact-EGFP mouse, we show that T cells exhibit a gain in fluorescence intensity following engagement of cognate tumour target cells. The GFP signal increase is governed by Erk1/2-dependent distal T cell receptor (TCR) signalling and its magnitude correlates with IFN-γ and TNF-α production, which are hallmarks of T cell activation. Enhanced fluorescence was due to increased translation of Lifeact-EGFP protein, without an associated increase in its mRNA. Activation-induced gains in fluorescence were also observed in naïve and CD4+ T cells from the Lifeact-EGFP reporter, and were readily detected by both flow cytometry and live cell microscopy. This unique, translationally controlled reporter of effector T cell activation simultaneously enables tracking of cell morphology, F-actin dynamics and activation state in individual migrating T cells. It is a valuable addition to the limited number of reporters of T cell dynamics and activation, and opens the door to studies of translational activity and heterogeneities in functional T cell responses in situ.
Foot thermometry with mHeath-based supplementation to prevent diabetic foot ulcers: A randomized controlled trial
Authors: Lazo-Porras Maria , Bernabe-Ortiz Antonio , Taype-Rondan Alvaro , Gilman Robert H. , Malaga German , Manrique Helard , Neyra Luis , Calderon Jorge , Pinto Miguel , Armstrong David G. , Montori Victor M. , Miranda J. Jaime 
Published: February 2020

Background: Three previous clinical trials have found that thermometry use reduced diabetic foot ulcers (DFUs) incidence four- to ten-fold among individuals with diabetes at high-risk of developing a DFU. However, these benefits depend on patient adherence to self-assessment. Therefore, novel approaches to improve self-management thermometry adherence are needed. Our objective was to compare incidence of DFUs in the thermometry plus mobile health (mHealth) reminders intervention arm vs. thermometry-only control arm. Methods: We conducted a randomized trial, enrolling adults with type 2 diabetes mellitus at risk of foot ulcers (risk groups 2 or 3) but without foot ulcers at the time of recruitment and allocating them to control (instruction to use a liquid crystal-based foot thermometer daily) or intervention (same instruction supplemented with text and voice messages with reminders to use the device and messages to promote foot care) groups and followed for 18 months. The primary outcome was time to occurrence of DFU. A process evaluation was also conducted. Results: A total of 172 patients (63% women, mean age 61 years) were enrolled; 86 to each study group. More patients enrolled in the intervention arm had a history of DFU (66% vs. 48%). Follow-up for the primary endpoint was complete for 158 of 172 participants (92%). DFU cumulative incidence was 24% (19 of 79) in the intervention arm and 11% (9 of 79) in the control arm. After adjusting for history of foot ulceration and study site, the Hazard Ratio (HR) for DFU was 1.44 (95% CI 0.65, 3.22). Adherence to ≥80% of daily temperature measurements was 87% (103 of 118) among the study participants who returned the logbook, with no difference between the intervention and control arms. Conclusions: This trial contributes to the evidence about the value of mHealth in preventing diabetes foot ulcers. Trial registration: ClinicalTrials.gov NCT02373592 (27/02/2015)
Lighting for color vision examination in the era of LEDs: the FM100Hue Test
Authors: Dain Stephen J. , Atchison David A. , Hovis Jeffery K. , Boon Mei-Ying 
Published: February 2020

Lighting conditions nominated for color vision testing are many and
varied. The recommendation of CIE color rendering index (CIE CRI)

≥

90

and correlated color temperature of
close to 6500 K is widely made for color vision testing generally.
With the demise of incandescent and fluorescent lighting and their
replacement by light-emitting diodes (LEDs), this is an opportune time
to revisit the recommendation. In this paper, we consider the current
sources, acceptable and unacceptable, and improvements to the
recommendation as it applies to the Farnsworth–Munsell 100 Hue Test
(FM100Hue Test). We conclude that there is no need to treat LEDs as a
special case but propose a modified CRI measure.
Mid-infrared single-cycle light bullet self-reconstruction after an air gap under single-pulse femtosecond filamentation in LiF
Authors: Chekalin Sergey , Dormidonov Alexander , Kandidov Valerii , Kompanets Victor 
Published: February 2020

We have studied the penetration of the extremely compressed wave packet—“light bullet” (LB)—through an air gap upon femtosecond single-pulse mid-IR filamentation in LiF. Applying the laser coloration method and performing numerical simulations, we have found that the single-cycle LB, which is formed before the air gap up to 0.5 mm wide, completely recovers after passing a certain distance inside LiF after the gap. This distance demonstrates nonlinear dependence on the gap width and LB pathway before the gap. We conclude that the observed self-reconstruction of the LB is caused by the high localization of the light field in the air gap due to strongly convergent wave front of the bullet, while the effect of the surrounding low-energy background of the pulse can be neglected.
22.7  W mid-infrared supercontinuum generation in fluorotellurite fibers
Authors: Li Zhenrui , Jia Zhixu , Yao Chuanfei , Zhao Zhipeng , Li Nan , Hu Minglie , Ohishi Yasutake , Qin Weiping , Qin Guanshi 
Published: February 2020

In this Letter, we demonstrate 22.7 W mid-infrared (MIR) supercontinuum (SC) generation in all-solid fluorotellurite fibers. All-solid fluorotellurite fibers based on

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modified fluoroaluminate glasses are fabricated by using a rod-in-tube method. By using a 0.6 m long fluorotellurite fiber with a core diameter of 11 µm as the nonlinear medium and a high-power 1.93–2.5 µm SC fiber laser as the pump source, we obtain 22.7 W SC generation from 0.93 to 3.95 µm in the fiber for a pump power of 39.7 W. The 10 dB bandwidth is about 1633 nm, and the corresponding spectral range is from 1890 to 3523 nm. The optical-to-optical conversion efficiency is about 57.2%. Our results show that all-solid fluorotellurite fibers are promising nonlinear media for constructing high-power MIR SC light sources.
Comparison studies of excitonic properties and multiphoton absorption of near-infrared-I-emitting Cu-doped InP and InP/ZnSe nanocrystals
Authors: He Tingchao , Liu Huan , Li Junzi , Xiao Shuyu , Hu Wenbo , Qiu Xin , Lin Xiaodong , Gao Yang 
Published: February 2020

Cu-doped InP (Cu:InP) and InP/ZnSe nanocrystals (NCs) with near-infrared-I (NIR-I) emission were prepared and characterized. Femtosecond transient absorption spectra revealed that the epitaxial growth of a ZnSe diffusion barrier onto the Cu:InP core can amplify its exciton-dopant coupling strength, with the energy transfer times of

∼

220

p
s

for Cu:InP NCs and

∼

183

p
s

for Cu:InP/ZnSe NCs. Importantly, the Cu:InP/ZnSe NCs exhibit much larger two- and three-photon absorption cross sections, reaching

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at 1600 nm, compared with Cu:InP NCs.
Living Lab: Forschung und Praxis am Universitätscampus
Authors: Abel Pascal 
Published: February 2020

ZusammenfassungInnovationen und Nutzerbeteiligung sind heutzutage im Gestaltungsprozess von Informationssystemen untrennbar miteinander verzahnt. Im Living-Lab-Ansatz kommt die gemeinsame Entwicklung mit dem Nutzer an einen realen Ort. Dieser Forschungsansatz folgt damit dem Paradigma, dass die wichtigen Fragen unserer Zukunft nur gemeinsam von Wissenschaft, Wirtschaft und Zivilgesellschaft beantwortet werden können.In diesem Beitrag blicken wir in die Praxis der Campusgestaltung an der Technischen Universität Braunschweig. Dort wird seit dem Jahr 2015 der Campus zum Living Lab zur partizipativen Lebensraumgestaltung. Es werden Erfolgsfaktoren aufgezeigt, wie die Nutzerintegration durch DIY Guerilla Marketing gelingt oder wie Experimentierfreudigkeit zu systematischem und zufälligen Lernen führen kann. In einer Betrachtung der Entwicklungsschritte werden die Lernstufen und Hürden aufgezeigt. Der Aufbau von Infrastruktur wurde notwendiger Bestandteil und setzt sich aus dem Sharing von vorhandenen Gegenständen, Bereitstellung von Räumen und Neuanschaffungen zusammen. Die Integration von vorhandenen Organisationen im Bereich des Campuslebens erfolgt durch die gemeinsame Entwicklung eines Teilbereichs der Plattform und der Anpassung an die Bedürfnisse der Organisationen.
Messung von digitalem Stress im organisationalen Umfeld: Erfahrungen aus einer Fallstudie
Authors: Fischer Thomas , Riedl René 
Published: February 2020

ZusammenfassungDigitaler Stress ist eine Form von Stress, die aus der Interaktion mit Informations- und Kommunikationstechnologien sowie deren Allgegenwärtigkeit in Wirtschaft und Gesellschaft resultiert. Digitaler Stress ist weit verbreitet und hat weitreichende negative Konsequenzen, wie etwa verringerte Zufriedenheit am Arbeitsplatz oder Burnout. Bislang ist die Erforschung von digitalem Stress vor allem auf Untersuchungen in Laborumgebungen sowie Online-Umfragen beschränkt. In diesem Artikel fokussieren wir auf einen anderen Forschungsansatz, nämlich Feldforschung. Es werden Methoden verglichen, die zur Erforschung von digitalem Stress am Arbeitsplatz eingesetzt werden können. Konkret wurden in einer Fallstudie über drei Arbeitswochen folgende Messinstrumente eingesetzt: Online-Fragebogen, Online-Tagebuch, Brustgurt zur Aufzeichnung der Herzschlagfrequenz sowie Gerät zur Messung von Blutdruck am Handgelenk. Insgesamt 16 Teilnehmer aus der Fallstudienorganisation nutzten diese Messinstrumente weitgehend selbständig, so dass Interventionen der beteiligten Forscher auf ein Mindestmaß reduziert werden konnten. Auf Basis der gewonnen Erkenntnisse werden die eingesetzten Methoden auf der Basis von sechs Gütekriterien (Reliabilität, Validität, Sensitivität, Diagnostizität, Objektivität, Aufdringlichkeit) verglichen. Es zeigt sich, dass jedes Messinstrument Stärken und Schwächen hat. Daraus folgt, dass zur praxisorientierten Erforschung von digitalem Stress ein Methoden-Mix angewendet werden sollte.
Patient Generated Index in HIV Chemosensory & auditory complaints: An observational study
Authors: Kamel Usama Fawzy , Andrady Ushan 
Published: February 2020

HIV is a chronic manageable disease. The disease and/or antiretroviral therapy treatment may lead to patient complaints regarding their hearing and chemosensory perception. Patient Generated Index (PGI) has been a validated patient generated questionnaire, which is flexible to capture areas relevant to patients
[i]. It has not been used before to assess the chemosensory (smell and taste) and auditory concerns of HIV positive patients.

Methods:
PGI questionnaire was distributed to nineteen HIV patients attending the research clinic. Patients had five areas to record their perception in relation to senses (smell, taste and hearing). They then score how do they feel about this particular area, then they spend points to improve the area when needed. Patients were recruited from a HIV clinic after giving their informed consent matching inclusion/exclusion criteria. The questionnaire had five sections where patients identify problems matter to them in relation to smell, taste and hearing. The sixth question is generated by the patient in relation to other health areas of concern to the individual.

Results:
PGI scores (n=19) mean was 5.39 (range 1.08 8, SD 1.93). Smell mean scores 1.1, taste was 1 and hearing was 0.97
Smell was 20.4% of the total PGI score; taste was 18.6% and hearing 18% of the PGI score. Patients scored 2.32 (43% of the total PGI score) in other areas (back pain, arthritis, stomach pains, )

Conclusions:
This is an observational cohort study to document the PGI results in relation to auditory and chemosensory perception in HIV positive patients. Although auditory and chemosensory problems in five areas scores altogether 57% of the PGI score, others (one area question), patients scored 43% of the total PGI score. Other complaints preoccupied patients and were relatively more cumbersome than the three senses.

[i] Ruta D, Garratt A, Leng M, Russell I, MacDonald L. A New Approach to the Measurement of Quality of Life: The Patient-Generated Index. Medical Care. 1994 Nov;32(11):1109-1126
Adaptation of Identity Styles Scale-5 to Turkish: Validity and reliability study
Authors: Morsünbül Ümit , Uçar Mehmet Ertuğrul , Konal Bilge 
Published: February 2020

Individuals use different solution strategies in order to dea with issues related to identity. Berzonsky explains the concept of identity with different cognitive strategies which people use to deal with identity conflicts and identity styles that formed by these cognitive strategies. By using different cognitive strategies, Berzonsky proposed three different identity styles based on social-cognitive identity model. They are informational oriented, norm oriented and diffuse-avoidant oriented identity styles. The purpose of the present study is to adapt Identity Style Inventory-5 into Turkish. The research group consisted of 206. university students. To collect data Personal Information Form, Identity Style Inventory-5, Identity Style Inventory-3, and Utrecht-Management of Identity Commitments Scale were used. Exploratory and confirmatory factor analysis results showed that Identity Style Inventory-5 has three factor-structures that cause different identity formation. Correlations between identity styles and identity dimensions supported criterion validity. Cronbach’ coefficients and parallel form reliability were conducted to determine reliability. Results indicated that Identity Style Inventory-5 is reliable measurement tool. As a result, it can be said the Turkish version of Identity Style Inventory-5 is reliable and valid measurement tool to determine identity styles.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Bireyler; kimlik konularını ele almada farklı çözüm yolları kullanırlar. Berzonsky kimlik kavramını, bireylerin kimlik çatışmalarıyla baş etmede kullandıkları farklı bilişsel stratejiler ve bu stratejilere bağlı olarak şekillenen kimlik stilleri ile açıklamaktadır. Berzonsky sosyal-bilişsel kimlik modeline dayanarak üç farklı kimlik stili önermiştir. Bunlar bilgi yönelimli, norm yönelimli ve kaçınma yönelimli kimlik stilleridir. Bu çalışmanın amacı Kimlik Stilleri Ölçeği-5’in Türkçeye uyarlanmasıdır. Araştırma grubu 206 üniversite öğrencisinden oluşmaktadır. Veri toplamak amacıyla Kişisel Bilgi Formu, Kimlik Stilleri Ölçeği-5, Kimlik Stilleri Ölçeği-3 ve Utrecht Kimlik Bağlanma Ölçeği kullanılmıştır. Açımlayıcı ve doğrulayıcı factor analizleri Kimlik Stilleri Ölçeği-5’in kimlik gelişiminde farklı kimlik biçimlenmesine neden olan üç faktörlü bir yapıya sahip olduğunu göstermiştir. Kimlik stilleri ile kimlik boyutları arasındaki korelasyonlar ölçüt geçerliliği desteklemiştir. Güvenirliliği belirlemek amacıyla iç tutarlılık katsayılarına ve paralel form güvenirliliğine bakılmıştır. Sonuçlar Kimlik Stilleri Ölçeği-5’in güvenilir bir ölçme aracı olduğunu göstermiştir. Sonuç olarak Kimlik Stilleri Ölçeği-5’in Türkçe versiyonunun kimlik stillerini belirlemek amacıyla güvenilir ve geçerli bir ölçme aracı olduğu söylenebilir.
EWALUACJA ROLI SPOŁECZNEJ NAUCZYCIELI JĘZYKA NIEMIECKIEGO W KONTEKŚCIE ZABURZENIA STABILIZACJI ZAWODOWEJ
Authors: Ewa Papierz-Łapsa  
Published: February 2020

In an era of dynamically changing socio-economics and technological progress, many aspects of school education are being transformed. Teachers are required to be professional in the form of a demand for increasingly higher professional qualifications and competences, but are also required to fulfil specific social roles. These new determinants of the functioning of education create difficulties in the construction of the teacher's identity because the changes which are being introduced disturb professional stability and cause fears about the future. The challenge is to try to answer universal questions about the professional identity of the teacher, the ability to combine an exceptional sense of service, vocation and mission. This situation affects teachers of German and other foreign languages (FL).
The aim of this paper is to show how teachers of German as a FL perceive the changing school and how they assess the educational process that they co-create. Through biographical interviews, analyzed within the framework of Rubacha’s social role model (2000), an attempt is made to answer the question of how the social role of German teachers is changing as a result of the educational reform initiated in 2017 and what dilemmas are being caused by the changing role of the teacher. Statements from participants of the study will be presented that illustratethe disorder of stabilization of the profession, which results in a critical attitude to the changing situation in school, a disturbed attitude to the world, culture and other people. Impairment of the professional stabilization of German teachers is viewed in the context of the concept of their social role.