bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research
Authors: Araujo Beatriz Grisolia , Souza e Silva Luiz Felipe , de Barros Torresi Jorge Luiz , Siena Amanda , Valerio Berenice Cataldo Oliveira , Brito Mariana Dutra , Rosenstock Tatiana Rosado 
Published: August 2020

AbstractAmyotrophic lateral sclerosis (ALS) is a multifactorial and progressive neurodegenerative disease of unknown etiology. Due to ALS’s unpredictable onset and progression rate, the search for biomarkers that allow the detection and tracking of its development and therapeutic efficacy would be of significant medical value. Considering that alterations of energy supply are one of ALS’s main hallmarks and that a correlation has been established between gene expression in human brain tissue and peripheral blood mononuclear cells (PBMCs), the present work investigates whether changes in mitochondrial function could be used to monitor ALS. To achieve this goal, PBMCs from ALS patients and control subjects were used; blood sampling is a quite non-invasive method and is cost-effective. Different parameters were evaluated, namely cytosolic calcium levels, mitochondrial membrane potential, oxidative stress, and metabolic compounds levels, as well as mitochondrial dynamics and degradation. Altogether, we observed lower mitochondrial calcium uptake/retention, mitochondria depolarization, and redox homeostasis deregulation, in addition to a decrease in critical metabolic genes, a diminishment in mitochondrial biogenesis, and an augmentation in mitochondrial fission and autophagy-related gene expression. All of these changes can contribute to the decreased ATP and pyruvate levels observed in ALS PBMCs. Our data indicate that PBMCs from ALS patients show a significant mitochondrial dysfunction, resembling several findings from ALS’ neural cells/models, which could be exploited as a powerful tool in ALS research. Our findings can also guide future studies on new pharmacological interventions for ALS since assessments of brain samples are challenging and represent a relevant limited strategy.
Family Formation: an Intergenerational Comparison Subtitlte: The Relevance of Social Inequalities for Family Formation in a Transnational Migration Context
Authors: Ammann Dula Eveline 
Published: August 2020

AbstractHow do processes of family formation change over generations? What is the relevance of social inequalities for these processes and what kinds of strategies do family members develop to deal with them? Based on a case study of members of two generations from the same family using a biographical approach, we will demonstrate the diversity of family formation within one family. The article generates insights about the complexity of family formation processes, as previous research has shown that there is a fertility variation between and within migrant groups of different origins. The selected family is involved in a transnational migration process, originally from the former Yugoslavia, coming to Switzerland and then moving to Kosovo. Migration experiences started with the grandfathers’ seasonal work migration. The family members were affected by social inequalities based on class, gender and ethnicity that are analysed using the concept of socio-cultural boundaries. The results illustrate the ways restrictions on access to the labour market, discrimination, educational institutions and selective migration regimes influence and shape family formation processes. It reveals that members of the same family develop diverse strategies to deal with exclusion and discrimination processes comparing their positions in transnational fields. We show how these family negotiation processes are interrelated with ethnicity and class and change over the generations. Furthermore, the analysis reveals that the transmission of gender norms in this family is influenced by the experienced socio-cultural boundaries. In sum, we show the complexity of family formation processes and intergenerational changes in interaction with intersectional social inequalities that are also shaped by migration policies.
StanceVis Prime: visual analysis of sentiment and stance in social media texts
Authors: Kucher Kostiantyn , Martins Rafael M. , Paradis Carita , Kerren Andreas 
Published: August 2020

AbstractText visualization and visual text analytics methods have been successfully applied for various tasks related to the analysis of individual text documents and large document collections such as summarization of main topics or identification of events in discourse. Visualization of sentiments and emotions detected in textual data has also become an important topic of interest, especially with regard to the data originating from social media. Despite the growing interest in this topic, the research problem related to detecting and visualizing various stances, such as rudeness or uncertainty, has not been adequately addressed by the existing approaches. The challenges associated with this problem include the development of the underlying computational methods and visualization of the corresponding multi-label stance classification results. In this paper, we describe our work on a visual analytics platform, called StanceVis Prime, which has been designed for the analysis of sentiment and stance in temporal text data from various social media data sources. The use case scenarios intended for StanceVis Prime include social media monitoring and research in sociolinguistics. The design was motivated by the requirements of collaborating domain experts in linguistics as part of a larger research project on stance analysis. Our approach involves consuming documents from several text stream sources and applying sentiment and stance classification, resulting in multiple data series associated with source texts. StanceVis Prime provides the end users with an overview of similarities between the data series based on dynamic time warping analysis, as well as detailed visualizations of data series values. Users can also retrieve and conduct both distant and close reading of the documents corresponding to the data series. We demonstrate our approach with case studies involving political targets of interest and several social media data sources and report preliminary user feedback received from a domain expert.Graphic abstract
Recent Progress on Metal–Organic Framework and Its Derivatives as Novel Fire Retardants to Polymeric Materials
Authors: Zhang Jing , Li Zhi , Qi Xiao-Lin , Wang De-Yi 
Published: August 2020

AbstractHigh flammability of polymers has become a major issue which has restricted its applications. Recently, highly crystalline materials and metal–organic frameworks (MOFs), which consisted of metal ions and organic linkers, have been intensively employed as novel fire retardants (FRs) for a variety of polymers (MOF/polymer). The MOFs possessed abundant transition metal species, fire-retardant elements and potential carbon source accompanied with the facile tuning of the structure and property, making MOF, its derivatives and MOF hybrids promising for fire retardancy research. The recent progress and strategies to prepare MOF-based FRs are emphasized and summarized. The fire retardancy mechanisms of MOF/polymer composites are explained, which may guide the future design for efficient MOF-based FRs. Finally, the challenges and prospects related to different MOF-based FRs are also discussed and aim to provide a fast and holistic overview, which is beneficial for researchers to quickly get up to speed with the latest development in this field.
Risk of posterior capsular rupture during phacoemulsification cataract surgery in eyes with previous intravitreal antivascular endothelial growth factor injections
Authors: Nagar Anindyt M. , Luis Joshua , Kainth Nimrath , Panos Georgios D. , Mckechnie Cordelia J. , Patra Sudeshna 
Published: August 2020

Purpose:
To investigate whether previous intravitreal antivascular endothelial growth factor (VEGF) injections are a predictor for posterior capsular rupture (PCR) during phacoemulsification cataract surgery.

Setting:
Whipps Cross University Hospital Eye Treatment Centre, London, United Kingdom.

Design:
Single-center, retrospective, electronic medical record (EMR) database study with univariate analysis.

Methods:
Data were extracted from an EMR system on eyes undergoing phacoemulsification surgery between August 1, 2016, and January 1, 2018. Patient demographics, indication for intravitreal therapy, treatment type, the number of previous intravitreal injections (IVIs), diabetic status, surgeon grade, and operative complications were included as variables for analysis.

Results:
Data were available for 4047 cataract operations. Of these, 108 (2.7%) had undergone previous anti-VEGF IVI treatment. Three eyes were noted to have preoperative PC trauma and were excluded from the final analysis. The logistic regression analysis after exclusion of the eyes with pre-existing damage to the PC confirmed that previous anti-VEGF IVI treatment was associated with an increased risk of PCR when compared with the non-IVI group (6.67% vs 1.88%, P < .0001). There is a dose-dependent relationship between the number of anti-VEGF injections and the likelihood of PCR.

Conclusions:
Previous intravitreal anti-VEGF injections are significantly correlated with an increased risk of surgical PCR, despite the absence of visible structural damage to the posterior capsule preoperatively.
The translational sciences clinic: From bench to bedside
Authors: Halushka Perry , Loucks Tammy L. , Paranal Rechelle , Harvey Jillian , Briggman Kristen , Lee-Chavarria Diana , Feghali-Bostwick Carol 
Published: August 2020

Abstract
The mission of the National Center for Advancing Translational Science (NCATS) is to speed the development of drugs from discovery to approval to dissemination and implementation. The Medical University of South Carolina and the South Carolina Clinical and Translational Research Institute host a NCATS funded predoctoral T32 training grant (TL1) with a focus on translational research. Doctoral (PhD) trainees working at the bench usually have limited opportunity for clinical interactions to gain a clinical perspective on the diseases that are the focus of their dissertation research. To provide TL1 trainees with an opportunity to see how their research could be translated into improved patient care, we developed a mentored clinical exposure experience named the Translational Sciences Clinic. Trainees spend one-half day a week in a clinic related to their basic science research for one semester interacting with patients and clinical mentors and discuss the most recent literature related to the patient’s clinical problem with their clinical mentor. Trainees deemed the rotation to be one of the most rewarding experiences that they had as a part of their predoctoral training. Participating clinical mentors were also very enthusiastic and agreed that they would be willing to mentor similar trainees again.
From lifespan to healthspan: the role of nutrition in healthy ageing
Authors: Wickramasinghe Kremlin , Mathers John C. , Wopereis Suzan , Marsman Daniel S. , Griffiths James C. 
Published: August 2020

AbstractAcross the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are plagued with the double-burden of energy excess and undernutrition. This has resulted in mental and physical deterioration, increased non-communicable disease rates, lost productivity, increased medical costs and reduced quality of life. While adequate nutrition is fundamental to good health at all stages of the life course, the impact of diet on prolonging good quality of life during ageing remains unclear. For progress to continue, there is need for new and/or innovative approaches to promoting health as individuals age, as well as qualitative and quantitative biomarkers and other accepted tools that can measure improvements in physiological integrity throughout life. A framework for progress has been proposed by the World Health Organization in their Global Strategy and Action Plan on Ageing and Health. Here, we focused on the impact of nutrition within this framework, which takes a broad, person-centred emphasis on healthy ageing, stressing the need to better understand each individual's intrinsic capacity, their functional abilities at various life stages, and the impact of their mental, and physical health, as well as the environments they inhabit.
Nationalism and Sport: A Review of the Field
Authors: Arnold Richard 
Published: August 2020

AbstractThe connection between nationalism and sport seems at once both obvious and manifest, with the most lavish praise of the nation often arising at sporting events. While a sizeable body of academic literature exists on the connection between the two concepts, it remains overlapping and unstructured. This state of the field review essay accounts for the major works in this field and categorizes it according to the function it fulfills in the subfield. Specifically, it focuses on sport as a mechanism for the diffusion and creation of nationalism, sport under conditions of globalization at Sporting Mega Events (SMEs), and the connection between sport and the distinction between civic and ethnic definitions of nationality.
Relating pollen representation to an evolving Amazonian landscape between the last glacial maximum and Late Holocene
Authors: Smith Richard J. , Mayle Francis E. , Maezumi S. Yoshi , Power Mitchell J. 
Published: August 2020

AbstractIn contrast to temperate regions, relationships between basin characteristics (e.g., type/size) and fossil pollen archives have received little attention in Amazonia. Here, we compare fossil pollen records of a small palm swamp (Cuatro Vientos; CV) and a nearby large lake (Laguna Chaplin, LCH) in Bolivian Amazonia, demonstrating that palm swamps can yield Quaternary pollen archives recording the history of terrestrial vegetation beyond the basin margin, rather than merely a history of localized swamp vegetation dynamics. The pollen assemblages from these two contrasting basins display remarkable agreement throughout their late Quaternary history, indicating past drier climates supported savanna landscape during the last glacial maximum (LGM; 24,000–18,000 cal yr BP) and savanna/semideciduous forest mosaic during the middle Holocene (7000-4750 cal yr BP) at both regional (inferred from LCH) and local (inferred from CV) spatial scales. Additionally, the local-scale catchment of CV and the basin's proximity to the riverine forests of the Río Paraguá enables exploration of the extent of gallery/riverine forests during the LGM and middle Holocene. We show that, between 24,000–4000 cal yr BP, riverine/gallery rainforests were substantially reduced compared with present, challenging the hypothesis that gallery rainforests were important refugia for rainforest species during the drier LGM and middle Holocene.
Atapuerca Neanderthal landscape at Fuente Mudarra site in Burgos, Spain, during Marine Isotope Stages 5–3
Authors: Santamaría Marta , Navazo Marta , Benito-Calvo Alfonso , Alonso Rodrigo , López Gloria I. , Carbonell Eudald 
Published: August 2020

AbstractFuente Mudarra is on a gentle slope on the left bank of the Pico River, near Sierra de Atapuerca, Burgos, Spain. A 12−m2test pit was dug at this large open-air site between 2012 and 2017. Several upper Pleistocene archaeological levels were documented. Results from Fuente Mudarra confirm that Neanderthal groups, little represented at cave sites, occupied Sierra de Atapuerca from the end of the middle Pleistocene and during the upper Pleistocene. The site also provides insight into Neanderthal spatial organization in the Atapuerca area and whether they used the caves in an occasional, non-habitual way like the open-air sites.
Epistaxis as a marker for severe acute respiratory syndrome coronavirus-2 status – a prospective study
Authors: Hussain MH , Mair M , Rea P 
Published: August 2020

AbstractObjectiveTo evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.MethodsA prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.ResultsThe mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).ConclusionEpistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.
Differences in the cnidomes and toxicities of the oral arms of two commercially harvested rhizostome jellyfish species in Thailand
Authors: Kondo Yusuke , Suzuki Yasuko , Ohtsuka Susumu , Nagai Hiroshi , Tanaka Hayato , Srinui Khwanruan , Miyake Hiroshi , Nishikawa Jun 
Published: August 2020

AbstractIn Thailand, two species of rhizostome jellyfish, Rhopilema hispidum and Lobonemoides robustus, are commercially harvested. The cnidomes, nematocyst size and toxicities were compared between these species. Rhopilema hispidum and L. robustus each had four types of nematocysts on their oral arms. For R. hispidum, these nematocyst types included two types of isorhiza and two types of rhopaloid, while in L. robustus, there were three types of isorhiza and one type of rhopaloid. For R. hispidum, tubule lengths of the largest nematocyst type (large round isorhiza; mean ± SD = 313.8 ± 62.2 μm) were significantly longer than those of L. robustus (large ellipsoid rhopaloid; 162.1 ± 38.5 μm). Using the freshwater shrimp, Palaemon paucidens, in a bioassay, we determined that the lethal nematocyst concentrations for R. hispidum and L. robustus were 5705.3 ± 1118.1 and 3408.3 ± 1032.9 unit g−1 wet weight, respectively, and that these concentrations were significantly higher in the former than in the latter.
Executive deficits in schizophrenia: mediation by processing speed and its relationships with aging
Authors: Thuaire Flavien , Rondepierre Fabien , Vallet Guillaume T. , Jalenques Isabelle , Izaute Marie 
Published: August 2020

AbstractBackgroundExecutive deficits are a core characteristic of schizophrenia. Yet, the origin of these impairments remains unclear as they may be caused by processing slowing. This issue is of particular interest for aging insofar as cognitive aging is also associated with a decline in executive functioning and a slowing of processing speed. As schizophrenia patients’ life expectancy increases, a better understanding of the origin of older patients’ cognitive deficits becomes essential so that healthcare can be adapted to suit them. This study aims to determine whether processing speed mediates how schizophrenia affects executive functions and whether these relationships are moderated by age.MethodsSixty-two schizophrenia patients (27 women) and 62 healthy comparison subjects matched for age (range: 18–76 years), gender and education performed neurocognitive tests to evaluate their executive functions (shifting, updating, inhibition and access) and processing speed.ResultsProcessing speed mediated the effect of schizophrenia on the four specific executive functions, and age moderated this mediation for shifting, updating and access, but in different ways. Age moderated the effect of processing speed on shifting, the direct effect of schizophrenia on access, and both the effect of processing speed and the direct effect of schizophrenia on updating.ConclusionsThis research highlights the need to evaluate processing speed routinely during therapeutic follow-up, as it is easy and simple to assess and appears to be at the heart of the cognitive deficits in schizophrenia. Finally, processing speed abilities yield information about the evolution of cognition with aging in schizophrenia.
Theorizing Popular Sovereignty in the Colony: Abul Aʿla Maududi's “Theodemocracy”
Authors: Iqtidar Humeira 
Published: August 2020

AbstractAbul Aʿla Maududi (1903–1979), the influential Indo-Pakistani Islamist thinker, proposed a detailed vision of what he called “theodemocracy.” This has been seen widely as a theocracy despite Maududi's explicit rejection of the term and its philosophical underpinnings. I suggest here that Maududi's vision of theodemocracy opens up a productive space for reflection on the relationship between popular and state sovereignty. Maududi saw popular sovereignty as an ethical problem; it corrupted the potential for individual moral development that the institutional mechanism of the state could otherwise allow for. Highlighting the complicated relationship of his ideas with colonial rule, and showing that he used the colonial liberal state as both a foiland modelfor his analysis, I argue here that “theodemocracy” was his attempt at divorcing sovereignty from the state. This endeavor generated creative tensions, and forms an important contribution to the global discussion about sovereignty and the state.
Moral marketplaces: regulating the food markets of late Elizabethan and early Stuart London
Authors: Taverner Charlie 
Published: August 2020

AbstractThis article examines the economic culture of urban food markets in early modern England. It focuses on London between 1590 and 1640 to argue that market regulation, even in fast-growing, commercializing cities, was underpinned by moralized values. It also assesses a largely untapped citywide book of fines, containing payments for regulatory offences. The first section outlines London's market system and regulation, the second looks at enforcement in practice and the third discusses the underlying values. This contributes to our understanding of day-to-day food marketing and proposes that studies of ‘moral economy’ should examine everyday commerce and major cities.