bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rapid assessment of migrant careworkers’ psychosocial status during Israel’s COVID-19 lockdown
Authors: Attal Jordan Hannink , Lurie Ido , Neumark Yehuda 
Published: November 2020

Abstract

Background
Israel hosts nearly 70,000 migrant careworkers. Migrant careworkers work and live with populations extremely vulnerable to the novel Coronavirus, including the elderly and people with pre-existing physical conditions. This rapid assessment aimed to explore psychosocial status and mental wellbeing of migrant careworkers in Israel during the ongoing Covid-19 pandemic and determine risk and protective factors associated with mental distress, anxiety, and depression.

Methods
This quantitative study was conducted via an online survey. The online survey collected social and demographic data, including country of origin, residence, age, sex, and time in Israel. In addition, questions were asked about knowledge of COVID-19 guidelines, access to supplies, and COVID-related racism. Respondents also completed a psychosocial screening tools, the Hopkins Symptom Checklist-10 (HSCL-10), which was used to screen for depression and anxiety.

Results
As of May 3rd, 2020, 307 careworkers responded to the online survey, of whom 120 (39.1%) were found symptomatic using the HSCL-10. Separating the HSCL-10 into subscales, 28.0% were symptomatically anxious, and 38.1% were symptomatic for depression. In multivariate regression, emotional distress was associated with household food insecurity (OR: 5.85; p < 0.001), lack of confidence to care for oneself and employer during the pandemic (OR: 3.85; p < 0.001), poorer general health (OR: 2.98; p < 0.003), non-Philippine country of origin (OR: 2.83; p < 0.01), female sex (OR: 2.34; p < 0.04),, and inversely associated with age (p < 0.03). While 87.6% of careworkers reported having access to hand sanitization materials regularly, only 58.0% had regular access to a medical grade mask, and 21.5% reported household food insecurity. Moreover, 40.0% of careworkers claimed to lack confidence to care for themselves and their employer during the COVID-19 pandemic.

Conclusions
Migrant careworkers exhibited high levels of mental distress during the COVID-19 lockdown, associated with lack of confidence or resources to properly care for themselves and their employer. Guidelines and support programs specific to the carework sector, that respect their rights and guard their health, must be developed as part of a coordinated COVID-19 response.
Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic
Authors: Sousa-Pinto Bernardo , Heffler Enrico , Antó Aram , Czarlewski Wienczyslawa , Bedbrook Anna , Gemicioglu Bilun , Canonica G. Walter , Antó Josep M. , Fonseca João Almeida , Bousquet Jean 
Published: November 2020

Abstract

Background
An increase in online searches on health topics may either mirror epidemiological changes or reflect media coverage. In the context of COVID-19, this is particularly relevant, as COVID-19 symptoms may be mistaken for those of respiratory disease exacerbations. Therefore, we aimed to assess Internet search patterns on asthma and chronic obstructive pulmonary disease (COPD) in the context of COVID-19, as compared to searches on other chronic diseases.

Methods
We retrieved Google Trends (GTs) data on two respiratory (asthma and COPD) and three non-respiratory (diabetes, hypertension, and Crohn’s disease) chronic diseases over the past 5 years (up to May 31, 2020). For 54 countries, and for each disease, we built autoregressive integrated moving average (ARIMA) models to predict GTs for 2020 based on 2015–2019 search patterns. In addition, we estimated the proportion of searches in which COVID-19-related terms were used. To assess the potential impact of media coverage on online searches, we assessed whether weekly “asthma” GTs correlated with the number of Google News items on asthma.

Results
Over the past 5 years, worldwide search volumes for asthma and COPD reached their maximum values in March 2020. Such was not observed for diabetes, hypertension and Crohn’s disease. In 38 (70%) countries, GTs on asthma were higher in March 2020 than the respective maximum predicted values. This compares to 19 countries for COPD, 23 for hypertension, 11 for Crohn’s disease, and 9 for diabetes. Queries with COVID-19-related terms represented up to 47.8% of the monthly searches on asthma, and up to 21.3% of COPD searches. In most of the assessed countries, moderate-strong correlations were observed between “asthma” GTs and the number of news items on asthma.

Conclusions
During March 2020, there was a peak in searches on asthma and COPD, which was probably mostly driven by media coverage, as suggested by their simultaneity in several countries with different epidemiological situations.
Research on investment portfolio model based on neural network and genetic algorithm in big data era
Authors: Zhou Wei , Zhao Yuanjun , Chen Weiwei , Liu Yanghui , Yang Rongjun , Liu Zheng 
Published: November 2020

Abstract
With the maturity of neural network theory, it provides new ideas and methods for the prediction and analysis of stock market investment. The purpose of this paper is to improve the accuracy of stock market investment prediction, we build neural network model and genetic algorithm model, study the law of stock market operation, and improve the effectiveness of neural network and genetic algorithm. Through the empirical research, it is found that the neural network model can make up for the shortcomings of the traditional algorithm through the optimization of genetic algorithm.
Time-restricted feeding downregulates cholesterol biosynthesis program via RORγ-mediated chromatin modification in porcine liver organoids
Authors: Zhang Kexin , Li Hao , Xin Zimeng , Li Yanwei , Wang Xiaolong , Hu Yun , Liu Haoyu , Cai Demin 
Published: November 2020

Abstract

Background
Time-restricted feeding (TRF) is a dieting strategy based on nutrients availability and diurnal rhythm, shown to improve lipid metabolism efficiency. We have demonstrated previously that retinoic acid-related (RAR) orphan receptor (ROR) γ is the primary transcription factor controlling cholesterol (CHO) biosynthesis program of animals. However, the functional role of RORγ in liver physiology of pigs in response to TRF has not been determined, largely due to the lack of functional models and molecular tools. In the present study, we established porcine liver organoids and subjected them to restricted nutrients supply for 10-h during the light portion of the day.

Results
Our results showed that TRF regimen did not alter hepatocyte physiology, including unchanged cell viability, caspase 3/7 enzyme activity and the gene signature of cell proliferation in porcine liver organoids, compared to the control group (P > 0.05). Furthermore, we found that TRF downregulated the hepatic CHO biosynthesis program at both mRNA and protein levels, along with the reduced cellular CHO content in porcine liver organoids (P < 0.05). Using unbiased bioinformatic analysis of a previous ChIP-seq data and ChIP-qPCR validation, we revealed RORγ as the predominant transcription factor that responded to TRF, amongst the 12 targeted nuclear receptors (NRs) (P < 0.05). This was likely through RORγ direct binding to the MVK gene (encoding mevalonate kinase). Finally, we showed that RORγ agonists and overexpression enhanced the enrichment of co-factor p300, histone marks H3K27ac and H3K4me1/2, as well as RNA polymerase II (Pol-II) at the locus of MVK, in TRF-porcine liver organoids, compared to TRF-vector control (P < 0.05).

Conclusions
Our findings demonstrate that TRF triggers the RORγ-mediated chromatin remodeling at the locus of CHO biosynthesis genes in porcine liver organoids and further improves lipid metabolism.
Credentialing for eating disorder clinicians: a pathway for implementation of clinical practice standards
Authors: McLean Siân A. , Hurst Kim , Smith Hilary , Shelton Beth , Freeman Jeremy , Goldstein Mandy , Jeffrey Shane , Heruc Gabriella 
Published: November 2020

Abstract
Advances are needed to ensure safe and effective treatment is available for people with eating disorders. Recently developed clinical practice and training standards for mental health professionals and dietitians represent a significant step in this direction by providing a consensus statement on eating disorder treatment as a foundation on which to build competent practice. This commentary argues that a credentialing system could promote implementation of these practice standards through formal recognition of qualifications, knowledge, training and professional activities to meet minimum standards for delivery of safe and effective eating disorder treatment. Drivers for credentialing include the imperative to provide safe and effective care, promotion of workforce development in eating disorder practice and, importantly, readily available and transparent information for referrers, consumers, and carers to identify health professionals credentialed to provide eating disorder treatment. However, a number of factors must be considered to ensure that credentialing does not restrict access to care, such as prohibitively narrow criteria to become credentialed, absence of pathways for education, training, or professional development opportunities, and lack of consultation with or endorsement by stakeholders of the credentialing criteria, application and approval processes, and ways of identifying credentialed practitioners. Further work, including development of credentialing criteria and aligned training opportunities, currently being undertaken by the Australia & New Zealand Academy for Eating Disorders and the National Eating Disorders Collaboration in consultation with stakeholders in the eating disorders sector and health professions will advance understanding of the feasibility of a system of credentialing for eating disorders within Australia and New Zealand. The availability of clinical practice and training standards, supported by implementation pathways, including credentialing of eating disorders practitioners, aim to improve quality of life, reduce financial burden, and close the treatment gap.
What factors contribute to high mechanical strength of tabia? Case study of the tabia from coastal forts sites at Zhejiang, China
Authors: Zhang Cuisong , Zhang Bingjian , Cui Biao , Lin Guocong 
Published: November 2020

Abstract
Tabia is one of the most widely used construction materials in ancient China. In this work, the tabia samples from three coastal defense fort sites at Zhejiang Province, China, we analyzed to determine their component composition and physiochemical properties. The results show that these tabia samples exhibited high compressive strength, which could be as high as 4–9 MPa. Furthermore, the systematic analysis demonstrated that the high compressive strength was related to the following factors: (1) a suitable mass ratio of sand, lime, and clay; (2) an appropriate sand particle size ratio; and (3) the formation of hydrated calcium silicate (C-S-H). Moreover, sticky rice was also detected in the tabia samples. These findings are fundamentally important, which could be beneficial to further study of the craftsmanship of the coastal defense forts and could further provide essential guidance for the protection and restoration of the tabia relics.
Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis
Authors: Shen Xiaomin , Zhang Jiajie , Huang Yicheng , Tong Jiepeng , Zhang Li , Zhang Zhijuan , Yu Wei , Qiu Yunqing 
Published: November 2020

Abstract

Objectives
The aim of this study was to systematically assess the accuracy of circulating microRNAs (miRNAs) as a promising biomarker for sepsis via a meta-analysis.

Methods
PubMed, Cochrane Library, Embase, Web of Science, Scopus, and Ovid databases were searched up to April 3, 2020. The Quality in Prognostic Studies (QUADAS-2) tool was used to assess methodological quality. The pooled sensitivity (Sen), specificity (Spe), positive or negative likelihood ratios (PLR or NLR), diagnostic odds ratio (DOR), curve, and area under the curve (AUC) were calculated with 95% confidence interval (95% CI). The overall accuracy (OA) of miRNAs, procalcitonin (PCT), and C-reactive protein (CRP) was analyzed by the chi-square test.

Results
A total of 22 records were eligible for systematic review, including 2210 sepsis, 426 systemic inflammatory response syndrome (SIRS), and 1076 healthy controls (HC). The pooled Sen, Spe, and DOR of miRNAs were 0.80 (95% CI 0.75–0.83), 0.85 (95% CI 0.80–0.89), and 22 (15–32), respectively. The DOR of PCT and CRP were 17 (95% CI 4–68) and 7 (95% CI 1–48), respectively. The OA value of miRNAs (79.02%) and PCT (76.95%) were higher than CRP (61.22%) (P < 0.000). The subgroup analysis indicated that miRNAs in adults, serum type, downregulation of miRNA expression, criteria of Sepsis-3, internal reference of non-U6, and dysregulation expression of miR-223 had superior diagnostic accuracy. In addition, there was no significant publication bias among the included studies. Fagan’s nomogram showed valuable clinical utility.

Conclusions
Our meta-analysis indicated that the level of circulating miRNAs, particularly the miR-223, could be used as an indicator for sepsis.
Total and dissolved soil organic and inorganic carbon and their relationships in typical loess cropland of Fengu Basin
Authors: Lu Tongping , Wang Xiujun , Zhang Wenxi 
Published: November 2020

Abstract
There is evidence of connections between soil organic carbon (SOC) and inorganic carbon (SIC) in dryland of north China. However, fractions of SOC and SIC and the relationship are not well understood in the Loess Plateau that undergoes profound erosion and redeposition. A study was conducted in low-elevation cropland of Loess Plateau across two distinctive basins: Linfen basin (LFB) with lower soil pH (< 8.4) and subject to erosion–redeposition, and Yuncheng basin (YCB) with higher soil pH (> 8.6) and under the influence of the Yellow River. Soil samples were collected from 30 sites over 100 cm. We determined SOC, SIC, dissolved organic carbon (DOC) and other properties. Above 100 cm, SOC stock is significantly higher in LFB (10.0 ± 2.6 kg C m−2) than in YCB (6.9 ± 1.5 kg C m−2), but SIC lower in LFB (14.0 ± 2.5 kg C m−2) than in YCB (17.0 ± 5.7 kg C m−2). We find a significantly negative correlation between SOC and SIC stocks in LFB, but no clear relationship in YCB. DOC:SOC ratio (an indicator for DOC desorption or SOC stability) is significantly higher below 40 cm in YCB (1.9%) than LFB (1.2%), indicating stronger DOC desorption in YCB that has stronger hydrological process due to the influence of the Yellow River. Overall, SOC has a negative correlation with SIC and soil pH, and DOC:SOC ratio has a significantly positive correlation with soil pH. Our analyses suggest that erosion/re-deposition of topsoil is partly responsible for the negative SIC-SOC relationship in LFB, and high soil pH and stronger hydrological processes are attributable to relatively lower levels of SOC in YCB. This study highlights that soil carbon fractions in the lowland of Loess Plateau are influenced by many drivers, which leads to complex relationships between major soil carbon pools.
Sports and non-sports-related concussions among Medicaid-insured children: health care utilization before and after Ohio’s concussion law
Authors: Newton Alison , Yang Jingzhen , Shi Junxin , Sullivan Lindsay , Huang Lihong , Singichetti Bhavna , Zhu Motao , Felix Ashley S. 
Published: November 2020

AbstractObjectiveTo evaluate patterns of health care utilization for sports-related concussions (SRCs) and non-sports-related concussions (NSRCs) among Medicaid-insured children before and after the enactment of Ohio’s concussion law in April 2013.MethodsWe analyzed claim data from the Partners For Kids (PFK) Ohio Medicaid database. Concussion diagnoses were identified between April 1, 2008 and June 30, 2017. We compared frequency of concussions by age and sex across the law period. We evaluated type of health care utilization before and after law enactment using multinomial logistic regression.ResultsOver the 9 year study period, 6157 concussions were included, most of which (70.4%) were NSRCs. The proportion of SRCs increased with age. Among children younger than 5 years old, the majority (96.1%) of concussions were NSRCs. During the post-law period, greater odds of primary care visits than emergency department (ED) visits were observed for both SRCs (OR = 1.53; 95% CI 1.34, 1.75) and NSRCs (OR = 1.73; 95% CI 1.58, 1.90) compared to the pre-law period.ConclusionsWe observed higher proportions of health care utilization for NSRCs than SRCs in Medicaid insured children and a shift in health care utilization from the ED to primary care in the post-law period. SRCs and NSRCs are likely to have different patterns of health care utilization before and after the enactment of Ohio’s concussion law. Our results demonstrate that Ohio’s youth concussion law had a quantifiable impact on health care utilization.
Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging
Authors: Hoffmann Jan V. , Janssen Jan P. , Kanno Takayuki , Shibutani Takayuki , Onoguchi Masahisa , Lapa Constantin , Grunz Jan-Peter , Buck Andreas K. , Higuchi Takahiro 
Published: November 2020

Abstract

Background
Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+).

Methods
The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison.

Results
Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR.

Conclusions
While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.
Nest-site selection by the white-tailed eagle and black stork – implications for conservation practice
Authors: Zawadzki Grzegorz , Zawadzka Dorota , Sołtys Anna , Drozdowski Stanisław 
Published: November 2020

AbstractBackgroundNesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling birds. While two large European species – the black stork (Ciconia nigraL.) and white-tailed eagle (Haliaaetus albicillaL.) – are known to require old, large trees for nesting, we sought to investigate further by comparing species requirements at the levels of the nesting tree, nesting stand, and landscape. This entailed a detailed examination of forest features within circles of radius 15 m surrounding 16 and 19 trees holding the nests of storks and eagles respectively. The same parameters were also checked in the vicinity of 50 randomly-selected mature trees.ResultsOur results indicate different nesting preferences, with the eagles entirely confining themselves to Scots pine (Pinus sylvestrisL.) – a species also chosen by black storks, which nevertheless regularly favour pedunculate oak (Quercus roburL.). Both species select trees of greater girth than the random ones, but white-tailed eagles choose to nest in the vicinity of patches of mature old stands with a loose canopy, to the extent that nesting trees and surrounding trees are of similar ages. In contrast, black storks prefer “veteran” trees with low-set crowns that are much older than any others in their vicinity. Nesting trees of the eagles are away from roads and close to lakes, while black storks do not avoid roads.ConclusionsAs the ages of nesting trees of both species are greater than ages at final cutting in this region’s managed forest, silvicultural measures will need to be adjusted, with small patches of forest spared, or larger areas as “islands” of old-growth. Likewise, as tending and thinning are engaged in, certain trees with horizontal branches will need to remain, with relict trees also left untouched. As it happens, all of these recommendations are anyway key elements of close-to nature silviculture and multifunctional forestry.
Characterization of expansive soils treated with lignosulfonate
Authors: Chavali Rama Vara Prasad , Reshmarani B. 
Published: November 2020

Abstract
The current study examines the potential of lignosulfonate to enhance the engineering behavior of two locally available expansive soils. The expansive soils were collected from Vijayawada and Amaravathi, located in the Capital Region of Andhra Pradesh, India. The soils were treated with four different percentages (0.5, 1, 2, and 4) of lignosulfonate and were allowed to interact for 7 and 28 days. A series of laboratory tests such as unconfined compressive strength, cation exchange capacity and scanning electron microscopy were carried out on the soil specimens. The results indicated that lignosulfonate has significant influence on the strength behavior of expansive soils. The amount of fines content present in soils defines the optimum percentage of lignosulfonate. Lignosulfonate treatment resulted in reduced negative surface charge of soils and formation of Polymer chain microstructure along with flocculated or aggregated particle microstructure, which may attribute to the enhanced strength of the expansive soils.