bluuebunny/crossref_metadata_2025_split huggingface dataset:
Madrasah Al-Ahmadiah Al-Islamiah di Narathiwat, Thailand dan Koleksi Al-Quran: Satu Kajian Deskriptif
Authors: Syed Hassan Syed Najihuddin , Ibrahim Norhasnira , Salaeh Abdulloh , Zakaria Nidzamuddin , Mohamad Zainuzi Nurul Izzatul Huda 
Published: December 2020

Madrasah al-Ahmadiah al-Islamiah is one of the Islamic educational centers founded in Narathiwat, Thailand. This Madrasah was founded by local scholar Haji Ahmad bin Samae. The Madrasah also serves as the center for the collection of Malay and Islamic manuscripts in Southern Thailand. This article is aimed at investigating the background of the institution, and also listing the collection of manuscripts found there. Qualitative method has been used by applying the method of subject determination. Data was obtained from interview as well as books and paperworks that related to this topic. The finding showed that there are 70 manuscripts of Quran with different sizes have been conserved. This study is important in the effort to preserve and uplift the institution as well as increase academic mobility in maintaining and studying manuscripts of Malay’s Archipelago.
ABSTRAK
Madrasah al-Ahmadiah al-Islamiah adalah salah sebuah pusat pendidikan Islam yang diasaskan di Narathiwat, Thailand. Madrasah ini telah diasaskan oleh ilmuwan tempatan bernama Haji Ahmad bin Samae. Madrasah ini turut berperanan sebagai pusat pengumpulan manuskrip Melayu dan Islam di Selatan Thailand. Artikel ini bertujuan menyelidik latarbelakang institusi dan juga menyenaraikan koleksi manuskrip yang terdapat di situ. Metode kualitatif telah digunakan dalam mengumpulkan data kajian. Data telah dikumpulkan melalui temubual serta kajian kepustakaan yang berkaitan. Dapatan kajian menunjukkan bahawa terdapat 70 naskhah manuskrip Quran pelbagai saiz yang telah dipulihara. Kajian ini adalah penting dalam usaha memelihara, memartabatkan institusi tersebut serta dapat meningkatkan mobiliti akademik dalam pemuliharaan dan pengkajian khazanah manuskrip Nusantara.
ЦІННІСНІ ОРІЄНТИРИ ФОРМУВАННЯ ДУХОВНОЇ КУЛЬТУРИ В МАЙБУТНІХ ВИХОВАТЕЛІВ ЯК СКЛАДОВА ПРОФЕСІЙНОГО ІМІДЖУ
Authors: Колосова С. В. , Сирова Ю. В. 
Published: December 2020

У статті висвітлено окремі аспекти формування духовної культури майбутніх вихователів як складової частини іміджу педагога. Розкрито основні компоненти професійного іміджу педагога: природні якості (комунікабельність, емпатійність, рефлексійність, красномовність); якості, сформовані внаслідок виховання та навчання (морально-етичні уявлення, психологічне здоров’я, комунікаційні навички, духовна культура); життєвий і професійний досвід. Встановлено, що імідж вихователя в наукових дослідженнях розглядають у контексті проблем формування індивідуального стилю педагога і визначено як якісну характеристику особистості, яка сприяє прояву її внутрішніх установок, особистісних і професійних якостей, життєвих позицій, духовної культури. Здійснено аналіз різних поглядів на проблему формування духовності особистості. З’ясовано, що духовна культура залежить від психологічних особливостей особистості, її моральних цінностей, пов’язана з оціночними категоріями та з загальною культурою. Узагальнено основні ціннісні орієнтири формування духовної культури майбутніх фахівців дошкільного профілю: гуманістичні цінності (толерантність, емпатія, альтруїзм, перцепція); моральні цінності (совість, гідність, чесність, повага, правдивість, справедливість); професійні цінності (працелюбність, відповідальність, професійні знання та навички, педагогічний такт, професійна етика); самоосвітні цінності (рефлексія, прагнення до пізнання світу, себе, сенсу та призначення свого життя). Встановлено, що цілеспрямована робота по формуванню ціннісних орієнтирів в процесі фахової підготовки сприяє розвитку професійно-особистісної компетентності майбутніх педагогів дошкільного профілю.
ЖИТТЯ ОСОБИСТОСТІ У СМИСЛОЦІННІСНОМУ ПОСТУПІ
Authors: Бех І. Д. 
Published: December 2020

У статті акцент зроблений на тому, що місія кожної людини на Землі зводиться до ведення повноцінного життя та здійснення добрих вчинків за найвищим виміром духовності: жити так, щоб не гнатися за злом і не втікати від добра; нанизувати добрі справи так, щоб між ними не зоставалося найменшого проміжку; зводити свої вчинки до добробуту людства як до абсолюту одухотворення її духовних надбань. Підкреслюється необхідність відродження одного з найпоширеніших імперативів античної етики, естетики й педагогіки, згідно з яким поєднання приємного й корисного вважалося єдиним добротворчим процесом, у який включалася зростаюча особистість.
Автор зазначає, що зростаюча особистість має бути здатною до розуміння як внутрішнього світу іншої людини, так і світу власного, до простеження своїх душевних порухів; вона має наповнюватись суспільно корисними утвореннями, які несе світ людей. Ціннісне вдосконалення зростаючої особистості відбувається і через зберігання паростків добродійних поривань, і через очищення негативних станів від різноманітних нижчих потягів і настанов. Автором надається характеристика байдужості як провідного негативного утворення і характеристика бережливості як внутрішнього утворення, яке має запобігати втраті наявних духовних надбань.
Наголошується, що, поряд з буденними ситуаціями і відносинами, життя наповнене міжособистісними взаєминами вищого рівня; ним виступає ціннісний світогляд як провідний чинник становлення і розвитку особистості. Автор умовно диференціює дві групи особистостей: духовно досконалі й духовно примітивні особистості; і окреслює, якою має бути оптимальна поведінка духовно досконалої особистості стосовно особистості духовно примітивної.
У статті автор доходить висновку, що навіть у найменшому треба діяти так, щоб воно передбачало найвищу ціль, і тоді життя приноситиме заслужену радість.
Alteraciones de los niveles de las hormonas tiroideas y el síndrome metabólico
Authors: Fierro Vasco Sandy , Pacheco Toro Santiago , Vega Vasco Juan , Vega Vasco Silvana 
Published: December 2020

Introducción. Más del 10 % de la población sufre alteraciones de los niveles de la hormona Tiroides sin saber que lo padece, el diagnostico se realiza con niveles bajos de hormonas tiroideas y la elevación de la TSH, esta patología es más comunes en mujeres. Tanto el hipotiroidismo como el hipertiroidismo pueden conducir a eventos cardiovasculares, arritmias e insuficiencia cardiaca. Objetivo. Determinar el impacto de las Hormonas Tiroideas sobre los componentes lipídicos, triglicéridos y niveles de colesterol HDL, porque son parte de la definición de Síndrome Metabólico. Metodología. Una revisión bibliográfica sistemática, con información de artículos tipo metaanálisis, revisiones sistemáticas y estudio de casos y controles. Resultados. Cuando se presentan alteraciones en la función de la Hormona Tiroides pueden coexistir con el Síndrome Metabólico el mismo que es diagnosticado cuando la persona presenta tres o más de los siguientes rasgos, o toma medicamentos para controlarlos, circunferencia de la cintura mayor a 89 centímetros en mujeres y 102 centímetros en varones; Niveles elevados de triglicéridos mayor a 150 mg/dl; Colesterol de lipoproteínas de alta densidad (HDL) menos de 50 mg /dl en mujeres y 40 mg/dl en varones; Hipertensión arterial y Glucosa en ayunas elevada. Ambos están asociados significativamente con morbilidad y mortalidad y, por lo tanto, tienen un impacto sustancial en el cuidado de la salud, en todo el mundo. Conclusión. El Hipotiroidismo Subclínico es más frecuente en mujeres y el riesgo aumenta con la edad, por lo tanto, hay que tener una mayor atención al riesgo de desarrollar Síndrome Metabólico. Así también el grupo de Hipotiroidismo Subclínico fue asociado significativamente con un mayor riesgo de desarrollar Síndrome Metabólico.
Práticas interdisciplinares de cuidado por meio de uma residência multiprofissional em diabetes
Authors: Moreira Tatiana Rebouças , Negreiros Francisca Diana da Silva , Silva Lucilane Maria Sales da , Moreira Thereza Maria Magalhães , Carvalho Silvana Linhares de , Aquino Maria de Jesus Nascimento de , Araújo Samila Torquato , Montenegro Júnior Renan Magalhães 
Published: December 2020

O presente estudo descreve práticas interdisciplinares de cuidado desenvolvidas em uma residência multiprofissional em diabetes. Trata-se de estudo descritivo realizado em um Serviço de Endocrinologia e Diabetes. A coleta de dados ocorreu no período de setembro a dezembro de 2020, por meio de formulário semi-estruturado e observação direta. A amostra foi composta por 16 profissionais da área da saúde e de apoio. Os dados foram analisados de forma descritiva. Os resultados mostram que a residência multiprofissional em diabetes é uma formação permanente em saúde, promissora e inovadora, que busca agregar a teoria e a prática durante o exercício das atividades em serviço e possibilita o compartilhamento de informações na equipe multiprofissional, gerando condutas interdisciplinares, integradas e holísiticas. Desse modo, conclui-se que as práticas interdisciplinares de cuidado possibilitam, além de uma formação específica, a ampliação da assistência especializada em diabetes nos três níveis de atenção à saúde, subsidiando melhorias na qualidade de vida dos pacientes e a formação de profissionais qualificados para o mercado de trabalho.
Patterns of Infarction on MRI in Patients With Acute Ischemic Stroke and Cardio-Embolism: A Systematic Review and Meta-Analysis
Authors: Sharobeam Angelos , Churilov Leonid , Parsons Mark , Donnan Geoffrey A. , Davis Stephen M. , Yan Bernard 
Published: December 2020

Background: Cardioembolic strokes are common however atrial fibrillation, the most common cause, is often asymptomatic and difficult to detect. There is evidence that infarct topography and volume on magnetic resonance imaging may be associated with specific stroke etiologies.Aim: A systematic review and meta-analysis were undertaken to summarize the available evidence on the association between stroke etiology, infarct topography, and volume.Methods: A systematic review was conducted using Medline (OVID), Embase (OVID), and PubMed databases. Hand searches of the gray literature and of reference lists in relevant articles were also performed. A quality assessment was undertaken, based on the STROBE checklist. For each study, the number of patients with and without a CE source of stroke and infarct topography was collected and outcomes presented as odds ratios (OR) with 95% CI and p-values.Results: Four thousand eight hundred and seventy-three patients with ischemic stroke were included, of whom 1,559 were determined to have a CE source. Bilateral infarcts (OR 3.41; 95% CI 2.20–5.29; p &lt; 0.0001) and multiple territory infarcts (OR 1.57; 95% CI 1.12–2.21; p = 0.009) were more common in patients with a CE source of stroke, than patients without a CE source. Lacunar infarcts (OR 0.49; 95% CI 0.31–0.80; p = 0.004) were more likely to occur in patients without a CE source. No significant difference between the frequency of multiple infarcts (OR 0.96; 95% CI 0.57–1.61; p = 0.87) anterior circulation (OR 1.45; 95% CI 0.83–2.53; p = 0.19) or posterior circulation infarcts (OR 1.06; 95% CI 0.72–1.57; p = 0.75), between the two groups were identified. Three out of four studies examining volume, found a significant association between increased infarct volume and CE source of stroke. A sensitivity analysis with cryptogenic and undetermined stroke sources assumed to be cardioembolic, did not alter the associations observed.Conclusion: The findings of this systematic review and meta-analysis are broadly consistent with previous literature and provide more robust evidence on the association between infarct topography, volume and stroke etiology. Our findings may assist with refining cardiac investigations for patients with cryptogenic stroke, based on infarct topography.
Ketone Monoester Supplementation Does Not Expedite the Recovery of Indices of Muscle Damage After Eccentric Exercise
Authors: Martin-Arrowsmith Patrick W. , Lov Jamie , Dai Jiaying , Morais José A. , Churchward-Venne Tyler A. 
Published: December 2020

Purpose: The purpose of this study was to evaluate the effects of a ketone monoester supplement on indices of muscle damage during recovery after eccentric exercise.Methods: In a randomized, double-blind, independent group design, 20 moderately active healthy young adults consumed 360 mg per kg−1 bodyweight of a ketone monoester (KET) or energy-matched carbohydrate (CON) supplement twice daily following eccentric exercise (drop jumps). Maximal isometric voluntary contraction (MIVC) torque, counter-movement jump (CMJ) height, and muscle soreness were measured before (PRE), and immediately (POST), 24 h and 48 h post-exercise. Blood samples were collected for analysis of β-hydroxybutyrate (β-OHB), creatine kinase (CK), and select pro- and anti-inflammatory cytokines.Results: Peak blood β-OHB concentration after supplement intake was greater (P &lt; 0.001) in KET (4.4 ± 0.8 mM) vs. CON (0.4 ± 0.3 mM). Exercise increased CK concentration at 24 h and 48 h vs. PRE (time: P &lt; 0.001) with no difference between KET and CON. Exercise reduced MIVC (KET: −19.9 ± 14.6; CON: −22.6 ± 11.1%) and CMJ (KET: −11.0 ± 7.5; CON: −13.0 ± 8.7%) at POST relative PRE; however, there was no difference between KET and CON on the recovery of MIVC at 24 h (KET: −15.4 ± 20.4; CON: −18.7 ± 20.1%) or 48 h (KET: −7.2 ± 21.2; CON: −11.8 ± 20.2%), or CMJ at 24 h (KET: −9.2 ± 11.5; CON: −13.4 ± 10.8) or 48 h (KET: −12.5 ± 12.4; CON: −9.1 ± 11.7). Muscle soreness was increased during post-exercise recovery (time: P &lt; 0.001) with no differences between KET and CON. Monocyte chemoattractant protein-1 was greater (group: P = 0.007) in CON (236 ± 11 pg/mL) vs. KET (187 ± 11 pg/mL).Conclusion: In conclusion, twice daily ingestion of a ketone monoester supplement that acutely elevates blood β-OHB concentration does not enhance the recovery of muscle performance or reduce muscle soreness following eccentric exercise in moderately active, healthy young adults.
Analysis of Immune Microenvironment by Multiplex Immunohistochemistry Staining in Different Oral Diseases and Oral Squamous Cell Carcinoma
Authors: Qiao Bin , Huang Junwen , Mei Zi , Lam Alfred King-yin , Zhao Junfang , Ying Le 
Published: December 2020

PurposeThe aim is to investigate the impacts of using multiplex immunochemistry (mIHC) staining to analyses the co-expression of programmed death ligand-1 (PD-L1) and tumor infiltrating lymphocytes (TILs) [CD8+ T cells and Forkhead Box Protein 3 (FOXP3)+ regulatory T cells (Tregs)] in different oral diseases, and oral squamous cell carcinoma (OSCC).MethodsFormalin fixed paraffin-embedded tissue sections from different oral diseases were stained with PD-L1 and TILs (CD8+ T cells and FOXP3+ Tregs) by mIHC staining simultaneously. The whole slide was scanned digitally to observe the cell phenotypes stained in the microenvironment. The contents of each slice were read using a computer-aided method to analyze and the cell densities were calculated using statistical software.ResultsWe were able to characterize the tumor microenvironment (TME) of different oral diseases including oral leukoplakia (OLK), inflammatory gingiva (IG), oral lichen planus (OLP), and squamous cell carcinoma (SCC), with accurate visualization of various immune cells harboring complex immune phenotypes by mIHC staining. The results showed that PD-L1 was up-regulated in SCC tissues at different pathological stages, while CD8 and FOXP3 had no significant changes. The ratio of PD-L1/CD8 was also significantly up-regulated in SCC tissues compared with that of other oral diseases. In advanced stages of OSCC, the FOXP3/CD8 ratio increased, and immunosuppressive TME was more pronounced. In addition, we also found different immune phenotypes: the inflamed phenotype, immune-excluded phenotypes, and immune-desert phenotypes. By locating tumor epithelial cells, we found that PD-L1 expression is in both tumor cells and stromal cells.ConclusionsmIHC is useful for the visualization and evaluation of tumor microenvironment in immuno-oncology research. It allows single-cell imaging in situ and could effectively and quickly determine the immune phenotype of different oral diseases.
Radiomics Feature Activation Maps as a New Tool for Signature Interpretability
Authors: Vuong Diem , Tanadini-Lang Stephanie , Wu Ze , Marks Robert , Unkelbach Jan , Hillinger Sven , Eboulet Eric Innocents , Thierstein Sandra , Peters Solange , Pless Miklos , Guckenberger Matthias , Bogowicz Marta 
Published: December 2020

IntroductionIn the field of personalized medicine, radiomics has shown its potential to support treatment decisions. However, the limited feature interpretability hampers its introduction into the clinics. Here, we propose a new methodology to create radiomics feature activation maps, which allows to identify the spatial-anatomical locations responsible for signature activation based on local radiomics. The feasibility of this technique will be studied for histological subtype differentiation (adenocarcinoma versus squamous cell carcinoma) in non-small cell lung cancer (NSCLC) using computed tomography (CT) radiomics.Materials and MethodsPre-treatment CT scans were collected from a multi-centric Swiss trial (training, n=73, IIIA/N2 NSCLC, SAKK 16/00) and an independent cohort (validation, n=32, IIIA/N2/IIIB NSCLC). Based on the gross tumor volume (GTV), four peritumoral region of interests (ROI) were defined: lung_exterior (expansion into the lung), iso_exterior (expansion into lung and soft tissue), gradient (GTV border region), GTV+Rim (GTV and iso_exterior). For each ROI, 154 radiomic features were extracted using an in-house developed software implementation (Z-Rad, Python v2.7.14). Features robust against delineation variability served as an input for a multivariate logistic regression analysis. Model performance was quantified using the area under the receiver operating characteristic curve (AUC) and verified using five-fold cross validation and internal validation. Local radiomic features were extracted from the GTV+Rim ROI using non-overlapping 3x3x3 voxel patches previously marked as GTV or rim. A binary activation map was created for each patient using the median global feature value from the training. The ratios of activated/non-activated patches of GTV and rim regions were compared between histological subtypes (Wilcoxon test).ResultsIso_exterior, gradient, GTV+Rim showed good performances for histological subtype prediction (AUCtraining=0.68–0.72 and AUCvalidation=0.73–0.74) whereas GTV and lung_exterior models failed validation. GTV+Rim model feature activation maps showed that local texture feature distribution differed significantly between histological subtypes in the rim (p=0.0481) but not in the GTV (p=0.461).ConclusionIn this exploratory study, radiomics-based prediction of NSCLC histological subtypes was predominantly based on the peritumoral region indicating that radiomics activation maps can be useful for tracing back the spatial location of regions responsible for signature activation.
Atractylenolide-I Suppresses Tumorigenesis of Breast Cancer by Inhibiting Toll-Like Receptor 4-Mediated Nuclear Factor-κB Signaling Pathway
Authors: Long Fangyi , Lin Hong , Zhang Xiqian , Zhang Jianhui , Xiao Hongtao , Wang Ting 
Published: December 2020

Background: Toll-like receptor 4 (TLR4) is an essential sensor related to tumorigenesis, and overexpression of TLR4 in human tumors often correlates with poor prognosis. Atractylenolide‐I (AT-I), a novel TLR4-antagonizing agent, is a major bioactive component from Rhizoma Atractylodes Macrocephalae. Emerging evidence suggests that AT-I exerts anti-tumor effects on various cancers such as colorectal cancer, bladder cancer and melanoma. Nevertheless, the effects of AT-I on mammary tumorigenesis remain unclear.Methods: In order to ascertain the correlation of TLR4/NF-κB pathway with breast cancer, the expression of TLR4 and NF-κB in normal breast tissues and cancer tissues with different TNM-stages was detected by human tissue microarray and immunohistochemistry technology. The effects of AT-I on tumorigenesis were investigated by cell viability, colony formation, apoptosis, migration and invasion assays in two breast cancer cells (MCF-7 and MDA-MB-231), and N-Nitroso-N-methylurea induced rat breast cancer models were developed to evaluate the anti-tumor effects of AT-I in vivo. The possible underlying mechanisms were further explored by western blot and ELISA assays after a series of LPS treatment and TLR4 knockdown experiments.Results: We found that TLR4 and NF-κB were significantly up-regulated in breast cancer tissues, and was correlated with advanced TNM-stages. AT-I could inhibit TLR4 mediated NF-κB signaling pathway and decrease NF-κB-regulated cytokines in breast cancer cells, thus inhibiting cell proliferation, migration and invasion, and inducing apoptosis of breast cancer cells. Furthermore, AT-I could inhibit N-Nitroso-N-methylurea-induced rat mammary tumor progression through TLR4/NF-κB pathway.Conclusion: Our findings demonstrated that TLR4 and NF-κB were over expressed in breast cancer, and AT-I could suppress tumorigenesis of breast cancer via inhibiting TLR4-mediated NF-κB signaling pathway.
Mental Health Outcomes Among Healthcare Workers and the General Population During the COVID-19 in Italy
Authors: Rossi Rodolfo , Socci Valentina , Pacitti Francesca , Mensi Sonia , Di Marco Antinisca , Siracusano Alberto , Di Lorenzo Giorgio 
Published: December 2020

IntroductionDuring the COVID-19 pandemic, healthcare workers in Italy have been exposed to an unprecedented pressure and traumatic events. However, no direct comparison with the general population is available so far. The aim of this study is to detail mental health outcomes in healthcare workers compared to the general population.Methods24050 respondents completed an on-line questionnaire during the contagion peak, 21342 general population, 1295 second-line healthcare workers, and 1411 front-line healthcare workers. Depressive, anxious, post-traumatic symptoms and insomnia were assessed. Specific COVID-19 related potential risk factors were also considered in healthcare workers.ResultsDepressive symptoms were more frequent in the general population (28.12%) and front-line healthcare workers (28.35%) compared to the second-line healthcare workers (19.98%) groups. Anxiety symptoms showed a prevalence of 21.25% in the general population, 18.05% for second-line healthcare workers, and 20.55% for front-line healthcare workers. Insomnia showed a prevalence of 7.82, 6.58, and 9.92% for the general population, second-line healthcare workers, and front-line healthcare workers, respectively. Compared to the general population, front-line healthcare workers had higher odds of endorsing total trauma-related symptoms. Both second-line healthcare workers and front-line healthcare workers had higher odds of endorsing core post-traumatic symptoms compared to the general population, while second-line healthcare workers had lower odds of endorsing negative affect and dissociative symptoms. Higher total traumatic symptom score was associated with being a front-line healthcare worker, having a colleague infected, hospitalized, or deceased, being a nurse, female gender, and younger age.ConclusionThis study suggests a significant psychological impact of the COVID-19 pandemic on the Italian general population and healthcare workers. Front-line healthcare workers represent a specific at-risk population for post-traumatic symptoms. These findings underline the importance of monitoring and intervention strategies.