bluuebunny/crossref_metadata_2025_split huggingface dataset:
Author’s regional measurement of investment intensity of gross regional product of Irkutsk region
Authors: Filatov Evgeniy 
Published: November 2019

Abstract
The leading industrial Asian countries (Japan, South Korea, China) had one drawback, which became their advantage – raw material poverty and a significant population. That is what helped to push them on the path of creating innovative material values, i.e. industrial products with world quality. Investing in the process of new industrialization is one of the most important aspects of financial activity. As a result, the process of measuring the investment intensity of the gross regional product and its impact on economic efficiency is most relevant. The article deals with the analysis of investment intensity of gross regional product. The author introduced into scientific circulation indicators: investment intensity of gross regional product, science intensity of gross regional product and science return of invested capital. The article reveals the influence of factors affecting the change in the investment intensity of the gross regional product and provides methodological approaches to its calculation. The article presents an analytical, systematic statistical material for the analysis of key indicators revealing the impact on the change of investment intensity of the gross regional product. Article executed within the framework of a research project of ISC SB RAS № XI.174.1.4 «Activation of internal potential of resource specialization regions development (on the example of the Baikal region)».
Return on investment in REIT real estate funds
Authors: Gertsekovich David , Gorbachevskaya Ludmila , Grigorova Ludmila , Peshkov Vitaly 
Published: November 2019

Abstract
The article considers the shaping conditions of the diversified portfolio with abundance of REIT from various sectors of residential property, mortgage and mixed. Special focus will be on the choice of most attractive investment products with the “Return-Risk” Model offered by the authors. This model was tested on independent material, and the investment attractiveness results received were compared with other products such as common shares, exchange goods, money market, etc. The conclusion contains the data about the accumulated return which on average makes up 1,67%, and its dynamics allows to evaluate the optimal investment horizon.
Study on the dependence of the force of shock interaction on the body size using a mechanorheological model
Authors: Lapshin Vladimir 
Published: November 2019

Abstract
The issues of modeling processes and designs in various industries are crucial. Particular attention is paid to dynamic processes of movement, vibration and shock interaction of structural elements and mechanical systems. Using the viscoelastic plastic model, the influence of the size of a spherical body on the force of shock interaction was studied. With an increase in the diameter of a spherical body, the body mass and the radius of curvature increase. The impact of both factors and each separate factor was evaluated using mathematical models of shock interaction. With a simultaneous increase in the body mass and the radius of curvature due to an increase in the diameter of a spherical body, the force of shock interaction increases. It was identified that an increase in the body mass causes a more significant increase in the force of shock interaction. An increase in the radius of curvature causes a slight increase in the force of shock interaction. Simultaneous changes in two factors cause a more significant increase in the force of shock interaction. An increase in plasticity of the model decreases the force of shock interaction. Thus, the results of the study show that the force of shock interaction depends significantly on the size of an interacting body due to the influence of the body mass and the radius of curvature on the dynamics of movement and deformation of bodies.
Environmental aspects for the reconstruction of housing and communal services in the village Listvyanka of Irkutsk region
Authors: Lavygina Olga , Grebneva Oksana , Maizel Irina 
Published: November 2019

Abstract
This paper considers the environmental aspects of the transfer of heating systems from fuel oil to pellets. The pollutant emissions were calculated for two variants: when working on fuel oil and on pellets. The calculation of the pollutants dispersion were made. The results showed that in the operation of heat supply systems using pellet boilers there is a decrease in gross and maximum-one-time emissions of pollutants.
Ensuring Fire Safety of Constructions in Remote and Sparsely Populated Areas
Authors: Mashovich Andrei , Rusopov Vitaly , Zaiatdinov Oleg 
Published: November 2019

Abstract
The article presents the results of research in the field of creating new materials to ensure the fire safety of buildings and structures under construction and reconstructed architectural monuments. The efficiency of the implementation of these materials should be based on their technological applicability, environmental friendliness and economic feasibility. The directions in the construction associated with the construction and reconstruction of wooden buildings and structures and fire protection of rotational camps are particularly of interest at present. As a result of the research, a model to substantiate the efficiency of the application of the newly developed construction materials has been developed. The engineering solutions to implement the model in order to ensure the restriction of the spread of fire have been proposed.
On the issue of cost and timing of contract tenders for industrial and civil construction
Authors: Matveeva M V , Doroshenko T G , Sukhanova I A 
Published: November 2019

Abstract
A tender is a submission made by a prospective supplier in response to an invitation to tender. It makes an offer for the supply of goods or services. In construction, the main tender process is generally for the selection of the contractor that will construct the works. However, as procurement routes have become more complex, so tenders may be sought for a wide range of goods and services (for example, on a construction management contract the works are constructed by a number of different trade contractors each contracted to the client) and contractors may take on additional functions such as design and management.
Strength kinetics of bent reinforced concrete elements in the process of deep freezing
Authors: Pinus Boris , Khardaev Pyotr 
Published: November 2019

Abstract
The article discusses the acceptability of standardized regulatory approaches to the assessment of kinetics of the carrying capacity of bending reinforced concrete elements during cooling and freezing. Taking into account the physical consequences of frost destruction of concrete (layer-by-layer destruction) and employing numerical integration method, statistically representative samples of strength indicators for model beams were obtained, corresponding to experimental σb(T)-εb(T) diagrams at various levels of freezing to minus 60ºC. The necessary dependences of σs-εs were taken according to recommendations of the norms. A comparative analysis of the statistics of samples obtained was performed for concretes with equilibrium (W = 1.7%) and increased (W = 3.7%) humidity with reinforcement μ = 0,5÷4,0%. The non-identity of dynamics of the bearing capacity of the bent elements and pure concrete is established. An increase in the resistance to bending is likely, and its intensity depends on humidity, temperature and reinforcement. The most significant increase is expected in over-reinforced elements. However, its implementation is problematic due to the increased likelihood of brittle fracture. Acceptable convergence of the values calculated (according to Code of Practice 63.13330) and expected with the required assurance (99.73%) at equilibrium humidity and cooling to minus 40ºC is confirmed. In conditions of high moisture content and deeper cooling, the required assurance is not achieved.
Legal responsibility in the apartment building management
Authors: Samusevich Alexey 
Published: November 2019

Abstract
The article discusses problematic issues of the realization of legal responsibility in the implementation of the apartment building management. Also the legal nature of the apartment building managing contract is considered and its basic conditions are identified. It is noted that for breach of the obligations according to the apartment building management contract, a management organizations bear civil liability, in which can be expressed in one-sided termination of the contract with the apartment house owners. In turn, the management organization, protecting its rights, can also terminate this contract if the owners do not fulfill their obligations. In case if the management organization in the process of providing housing and communal services commits an administrative offense, it bears administrative responsibility, the measures of which are expressed in the form of the application of penalties.
TEM studies of conical scroll carbon nanotubes formed by aerosol synthesis
Authors: Kulnitskiy B , Karaeva A , Mordkovich V , Urvanov S , Bredikhina A 
Published: November 2019

Abstract
Conical carbon nanotubes were obtained by the method of gas-phase chemical decomposition of a carbon precursor on the surface of a catalytic particle suspended in a carrier gas stream (also known as “aerosol method”). TEM study at the JEM-2010 microscope showed that the observed angles at the vertex of the cones (apex angles) were predominantly 5°, 10°, 15° and 20° regardless of the presence of a catalyst particle inside the cone. The analysis of the apex angles witnesses that the nanotubes have a scroll type of structure. Two alternative explanations are proposed for the formation of an unconventional apex angle 5°. The peculiarities of destruction of the catalyst particles inside the nanotubes are revealed.
Control electronics for semiconductor spin qubits
Authors: Geck Lotte , Kruth Andre , Bluhm Hendrik , Waasen Stefan van , Heinen Stefan 
Published: December 2019

Abstract
Future universal quantum computers solving problems of practical relevance are expected to require at least 106 qubits, which is a massive scale-up from the present numbers of less than 50 qubits operated together. Out of the different types of qubits, solid state qubits are considered to be viable candidates for this scale-up, but interfacing to and controlling such a large number of qubits is a complex challenge that has not been solved yet. One possibility to address this challenge is to use qubit control circuits located close to the qubits at cryogenic temperatures. In this work we evaluate the feasibility of this idea, taking as a reference the physical requirements of a two-electron spin qubit and the specifications of a standard 65 nm complementary metal-oxide-semiconductor process. Using principles and flows from electrical systems engineering we provide realistic estimates of the footprint and of the power consumption of a complete control-circuit architecture. Our results show that with further research it is possible to provide scalable electrical control in the vicinity of the qubit, with our concept.
Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity
Authors: Jupp Bianca , Sawiak Steve J , van der Veen Bastiaan , Lemstra Suzanne , Toschi Chiara , Barlow Rebecca L , Pekcec Anton , Bretschneider Tom , Nicholson Janet R , Robbins Trevor W , Dalley Jeffrey W 
Published: November 2019

AbstractMaladaptive impulsivity manifests in a variety of disorders, including attention-deficit hyperactivity disorder (ADHD), depression, and substance use disorder. However, the etiological mechanisms of impulsivity remain poorly understood. In the present study, we used in-vivo proton magnetic resonance spectroscopy (1H-MRS) to investigate neurometabolite content in the prefrontal cortex (PFC) and striatum of rats exhibiting low- versus high-impulsive (LI, HI) behavior on a visual attentional task. We validated our 1H-MRS findings using regionally resolved ex-vivo mass spectroscopy, transcriptomics, and site-directed RNA interference in the ventromedial PFC. We report a significant reduction in myoinositol levels in the PFC but not the striatum of HI rats compared with LI rats. Reduced myoinositol content was localized to the infralimbic (IL) cortex, where significant reductions in transcript levels of key proteins involved in the synthesis and recycling of myoinositol (IMPase1) were also present. Knockdown of IMPase1in the IL cortex increased impulsivity in nonimpulsive rats when the demand on inhibitory response control was increased. We conclude that diminished myoinositol levels in ventromedial PFC causally mediate a specific form of impulsivity linked to vulnerability for stimulant addiction in rodents. Myoinositol and related signaling substrates may thus offer novel opportunities for treating neuropsychiatric disorders comorbid with impulsive symptomology.
Habitat transformation and climate change: Implications for the distribution, population status, and colony extinction of Southern Bald Ibis (Geronticus calvus) in southern Africa
Authors: Colyn Robin B , Henderson Catherine L , Altwegg Res , Smit-Robinson Hanneline A 
Published: November 2019

Abstract
Habitat transformation and loss is one of the greatest threats currently facing avian species. The cumulative impact of climate change on habitat loss is projected to produce disproportionate risk for endemic high-altitude species. The Southern Bald Ibis (Geronticus calvus) is an endemic high-altitude species found throughout highland grassland habitats in South Africa and Lesotho. The historical distribution has contracted notably and causal factors remain ambiguous. Furthermore, the historical population (1950–1970) was believed to be stable, but recent local surveys suggest colony declines and the current global population status remains largely unquantified. We assessed the current distribution and population status of the species through predictive modeling and trends in historical and recent colony counts across the species’ range. We examined climate and habitat change as potential causal factors contributing to the historical contraction in distribution, and projected the potential impact of future climate change predicted by global circulation models. Our study confirms that Southern Bald Ibis are of conservation concern. The loss of grasslands to expanding woody vegetation through bush encroachment was the most detrimental habitat transformation type associated with decreased colony growth and colony collapse. We recommend maintaining a minimum threshold of 50% or greater intact grassland habitat surrounding colonies to reduce colony extinction risk and promote colony persistence.
GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation
Authors: Wang Mo , Qian Lei , Li Jing , Ming Hao , Fang Li , Li Yingjia , Zhang Man , Xu Yaohua , Ban Yiqian , Zhang Weizhen , Zhang Youyi , Liu Yahan , Wang Nanping 
Published: November 2019

AbstractAimsSustained activation of β-adrenergic signalling induces cardiac fibrosis, which marks progression to heart failure. GHSR (growth hormone secretagogue receptor) is the receptor for ghrelin, which is an orexigenic gastric hormone with newly defined cardiovascular effects. The present study determined the effects of GHSR deficiency in a mouse model of isoproterenol (ISO)-induced cardiac fibrosis and examined the underlying mechanism.Methods and resultsHistochemical studies showed that GHSR deficiency exacerbated cardiac fibrosis. Quantitative RT–PCR, western blotting, and immunofluorescence staining demonstrated that cardiac fibroblasts isolated from GHSR−/− mice exhibited increased expression of marker genes for myofibroblast trans-differentiation (α-SMA, SM22, and calponin) upon transforming growth factor-β treatment compared to wild-type mice. RNA-sequencing of heart transcriptomes revealed that differentially expressed genes in GHSR−/− hearts were enriched in such biological processes as extracellular matrix organization, inflammatory response, lipid metabolism, cell cycle, migration, and adhesion. Particularly, GHSR deficiency increased Wnt/β-catenin pathway activation in ISO-induced myocardial fibrosis. In addition, loss of GHSR in macrophages instigated inflammasome activation with increased cleavage and release of interleukin-18.ConclusionThese results for the first time demonstrated that GHSR deficiency aggravated ISO-induced cardiac fibrosis, suggesting that GHSR was a potential target for the intervention of cardiac fibrosis.
Sex differences in heart failure
Authors: Lam Carolyn S P , Arnott Clare , Beale Anna L , Chandramouli Chanchal , Hilfiker-Kleiner Denise , Kaye David M , Ky Bonnie , Santema Bernadet T , Sliwa Karen , Voors Adriaan A 
Published: November 2019

Abstract
The overall lifetime risk of heart failure (HF) is similar between men and women, however, there are marked sex differences in the landscape of this condition that are both important and under-recognized. Men are predisposed to HF with reduced ejection fraction (HFrEF), whereas women predominate in HF with preserved ejection fraction (HFpEF). Sex differences are also notable in the penetrance of genetic cardiomyopathies, risk factors, e.g. breast cancer which may be associated with cancer treatment-induced cardiomyopathy, as well as sex-specific conditions such as peripartum cardiomyopathy (PPCM). This review outlines the key sex differences with respect to clinical characteristics, pathophysiology, and therapeutic responses to HF treatments. Finally, we address important differences in the prognosis of HF. A central hypothesis is that the higher risk of HFrEF in men compared to women may be attributable to their predisposition to macrovascular coronary artery disease and myocardial infarction, whereas coronary microvascular dysfunction/endothelial inflammation has been postulated to play a key role in HFpEF and maybe the common link among HF syndromes that women are predisposed to Takotsubo cardiomyopathy, PPCM, and breast cancer radiotherapy-induced cardiomyopathy. Under-pinning current sex disparities in HF, there is a paucity of women recruited to HF clinical trials (20–25% of cohorts) and thus treatment guidelines are predominantly based on male-derived data. Large gaps in knowledge exist in sex-specific mechanisms, optimal drug doses for women and sex-specific criteria for device therapy.
Intervention effectiveness by pharmacists integrated within an interdisciplinary health team on chronic complex patients
Authors: Acosta-García Hector , Alfaro-Lara Eva Rocío , Sánchez-Fidalgo Susana , Sevilla-Sánchez Daniel , Delgado-Silveira Eva , Juanes-Borrego Ana , Santos-Ramos Bernardo 
Published: November 2019

Abstract

Background
Nowadays, it is difficult to establish a specific method of intervention by the pharmacist and its clinical repercussions. Our aim was to identify interventions by pharmacists integrated within an interdisciplinary team for chronic complex patients (CCPs) and determine which of them produce the best results.

Methods
A systematic review (SR) was performed based on PICO(d) question (2008–18): (Population): CCPs; (Intervention): carried out by health system pharmacists in collaboration with an interdisciplinary team; (Comparator): any; (Outcome): clinical and health resources usage outcomes; (Design): meta-analysis, SR and randomized clinical trials.

Results
Nine articles were included: one SR and eight randomized clinical trials. The interventions consisted mainly in putting in order the pharmacotherapy and the review of the medication adequacy, medication reconciliation in transition of care and educational intervention for health professionals. Only one showed significant improvements in mortality (27.9% vs. 38.5%; HR = 1.49; P = 0.026), two in health-related quality of life [according to EQ-5D (European Quality of Life—5 Dimensions) and EQ-VAS (European Quality of Life—Visual Analog Scale) tests] and four in other health-related results (subjective self-assessment scales, falls or episodes of delirium and negative health outcomes associated with medication). Significant differences between groups were found in hospital stay and frequency of visits to the emergency department. No better results were observed in hospitalization rate. Otherwise, one study measured cost utility and found a cost of €45 987 per quality-adjusted life year gained due to the intervention.

Conclusions
It was not possible to determine with certainty which interventions produce the best results in CCPs. The clinical heterogeneity of the studies and the short follow-up of most studies probably contributed to this uncertainty.
Fish and fish side streams are valuable sources of high-value components
Authors: Välimaa Anna-Liisa , Mäkinen Sari , Mattila Pirjo , Marnila Pertti , Pihlanto Anne , Mäki Maarit , Hiidenhovi Jaakko 
Published: December 2019

AbstractThe current practice of fish processing generates increasing quantities of side streams and waste, such as skin, heads, frames, viscera, and fillet cut offs. These may account for up to 70% of the fish used in industrial processing. Low-value fish catches, and under-utilized fish species comprise another source of side streams. These side streams have been discarded in the environment leading to environmental problems or they have ended up as low commercial value products, such as feed for fur animals and aquaculture. However, several studies have shown that fish side streams contain valuable bioactive ingredients and fractions, such as fish oils, proteins and peptides, collagen, gelatin, enzymes, chitin, and minerals. These compounds and fractions may provide the opportunity to develop novel applications in health promoting foods, special feeds, nutraceuticals, pharmaceuticals, and cosmetic products. Better utilization of side streams and low-value fish would simultaneously improve both the environmental and ecological sustainability of production. This review summarizes the current knowledge on fish and fish side streams as sources of high-value components such as peptides with antimicrobial, antioxidative, antihypertensive, and antihyperglycemic properties, proteins such as fish collagen and gelatin, fish enzymes, fish oils and fatty acids, polysaccharides like glucosaminoglycans, chitin and chitosan, vitamin D, and minerals. Production technologies for recovering the high-value fractions and potential product applications are discussed. Furthermore, safety aspects related to the raw material, technologies, and fractions are considered.