bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for repeated emergency compulsory psychiatric admissions
Authors: de Jong Mark H. , Wierdsma André I. , Zoeteman Jeroen , van Boeijen Christina A. , Van Gool Arthur R. , Mulder Cornelis L. 
Published: December 2020

Background
The characteristics of patients who have repeated compulsory psychiatric admissions are largely unknown.

Aims
To investigate the frequency and risk factors for repeated emergency compulsory psychiatric admission (ECPA); and to identify targets for interventions to reduce repeated ECPA.

Method
Data were collected from a database of electronic patient files (EPFs) held by three psychiatric emergency services (PES) in the Netherlands. Analyses were based on the data for adult patients (aged 18–75 years) with a first PES contact in 2010–2015. Using descriptive statistics and regression analysis, we studied the associations between baseline patient factors and repeated ECPA and time to readmission, within a 2-year follow-up period.

Results
We included 6059 patients: 15.6% had two or more ECPAs. In total, 66% of second ECPAs had occurred within 6 months of the first. About 30% of all ECPAs were repeated ECPAs. Two baseline factors were associated with a higher frequency of a second ECPA: history of receiving any mental healthcare treatment, whether in-patient or out-patient or both, and a lower level of self-care. Three were associated with a lower frequency: ethnicity (other than Dutch), older age and suicidality. Lower Global Assessment of Functioning (GAF) scores and housing problems were associated with a shorter time to compulsory readmission and persistent psychiatric problems with a longer time to compulsory readmission.

Conclusions
We found that 15.6% of patients had two or more ECPAs. Two-thirds of the second ECPAs had occurred within 6 months of the first. Like earlier studies, the risk factors we identified suggest that interventions to reduce the risk of repeated compulsory psychiatric admission should seek to improve self-care, general daily functioning and homelessness.
Planar cell polarity: moving from single cells to tissue-scale biology
Authors: Mlodzik Marek 
Published: December 2020

ABSTRACT
Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal organogenesis, and it regulates many aspects of cell positioning and orientation during tissue morphogenesis, organ development and homeostasis. Suzanne Eaton used the power of Drosophila as a model system to study PCP, but her vision of, and impact on, PCP studies in flies translates to all animal models. As I highlight here, Suzanne's incorporation of quantitative biophysical studies of whole tissues, integrated with the detailed cell biology of PCP phenomena, completely changed how the field studies this intriguing feature. Moreover, Suzanne's impact on ongoing and future PCP studies is fundamental, long-lasting and transformative.
Controlling optical return loss in production silicon photonic metamaterial fiber couplers
Authors: Peng Bo , Barwicz Tymon , Bian Yusheng , Sahin Asli , Houghton Thomas , Hu Shuren , Rakowski Michal , Ayala Javier , Meagher Colleen , Sowinski Zoey , Stricker Andy , Jacob Ajey , Nummy Karen , Giewont Ken 
Published: December 2020

A cost-efficient and low-complexity optical input/output (I/O) packaging solution is a substantial challenge for volume production of photonic integrated circuits. To address this, metamaterial fiber couplers are an attractive solution for integrated photonic devices especially for optical I/O, interfacing standard optical fibers to photonic chips. They offer the advantages of refractive index engineering to achieve better mode match as well as higher fabrication tolerances. Metamaterial waveguides, as a fundamental building block of these fiber couplers, have attracted tremendous attention in recent years. Here, we report on effective optical return loss control in Si metamaterial waveguide designs to achieve ultra-low reflection loss in CMOS-compatible silicon photonics implemented in a 300 mm production line. Low backscattering is a substantial consideration for a range of applications. Here, a return loss of better than

−

30

d
B

is achieved.
Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation
Authors: Xiao Chong , Fu Xi , Wang Yuting , Liu Hong , Jiang Yifang , Zhao Ziyi , You Fengming 
Published: December 2020

BackgroundIron metabolism is essential because it plays regulatory roles in various physiological and pathological processes. Disorders of iron metabolism balance are related to various cancers, including hepatocellular carcinoma. Cancer stem-like cells (CSCs) exert critical effects on chemotherapy failure, cancer metastasis, and subsequent disease recurrence and relapse. However, little is known about how iron metabolism affects liver CSCs. Here, we investigated the expression of transferrin receptor 1 (TFR1) and ferroportin (FPN), two iron importers, and an upstream regulator, iron regulatory protein 2 (IRP2), in liver hepatocellular carcinoma (LIHC) and related CSCs.MethodsThe expression levels of TFR1, FPN and IRP2 were analysed using the GEPIA database. CSCs were derived from parental LIHC cells cultured in serum-free medium. After TFR1 knockdown, ROS accumulation and malignant behaviours were measured. The CCK-8 assay was performed to detect cell viability after TFR1 knockdown and erastin treatment.ResultsTFR1 expression was upregulated in LIHC tissue and CSCs derived from LIHC cell lines, prompting us to investigate the roles of TFR1 in regulating CSCs. Knockdown of TFR1 expression decreased iron accumulation and inhibited malignant behaviour. Knockdown of TFR1 expression decreased reactive oxygen species (ROS) accumulation induced by erastin treatment and maintained mitochondrial function, indicating that TFR1 is critical in regulating erastin-induced cell death in CSCs. Additionally, knockdown of TFR1 expression decreased sphere formation by decreasing iron accumulation in CSCs, indicating a potential role for TFR1 in maintaining stemness.ConclusionThese findings, which revealed TFR1 as a critical regulator of LIHC CSCs in malignant behaviour and stemness that functions by regulating iron accumulation, may have implications to improve therapeutic approaches.
The affects of cement space thickness and material type with application of micro-CT scanner on marginal discrepancy of restoration
Authors: Mosharraf Mosharraf , Azizi Amir , Naziri Babak , Abolhasani Majid 
Published: December 2020

Objective: Studies demonstrated that as one of the newly developed restorative materials, monolithic zirconia resolved several issues of zirconia restoration. Therefore, marginal accuracy and internal fit are necessary for clinical success and quality of restorations, and cement space may influence the marginal fit. Thus, the present research aimed to investigate the effects of the cement thickness and kind of restoration on the marginal discrepancy. Material and methods: In this study, 20 maxillary left first molars, prepared by DRSK Co., were used to fabricate a full crown. Two types of material included monolithic zirconia (Zolid) and Sintron were used to make a full crown. Samples from each group were scanned by dental laboratory 3D scanner and designed and processed using CAD-CAM. The samples were divided into four groups of five with 30- and 50- µm cement spaces. In order to assess the vertical marginal discrepancy, the crowns were fitted on their respective teeth without using any mediator and examined by a micro-CT scanner. Data were analyzed by SPSS software. Results: It has been found that marginal discrepancy in Sintron is higher than the discrepancy of monolithic zirconia. In fact, monolithic zirconia with 50-micron cement space exhibited the least marginal discrepancy and the cement space in Sintron did not significantly influence the marginal discrepancy. Conclusion: It has been concluded that the material kinds and cement space influence the restoration marginal discrepancy constructed by digital workflow.
KEYWORDSDental cements; Dental marginal adaptation; X-Raymicrotomography.
Periodic solutions for a differential inclusion problem involving the p(t)-Laplacian
Authors: Chen Peng , Tang Xianhua 
Published: December 2020

Abstract
In the present paper, we consider the nonlinear periodic systems involving variable exponent driven by p(t)-Laplacian with a locally Lipschitz nonlinearity. Our arguments combine the variational principle for locally Lipschitz functions with the properties of the generalized Lebesgue-Sobolev space. Applying the non-smooth critical point theory, we establish some new existence results.
Repositorien als Tools für ein umfassendes Forschungsdatenmanagement
Authors: Blumesberger Susanne 
Published: December 2020

Zusammenfassung
Der Beitrag soll zeigen, inwieweit Repositorien eine Rolle beim Forschungsdatenmanagement spielen und welche Möglichkeiten und Herausforderungen damit verbunden sind. Der Umgang mit Daten hat sich in den letzten Jahren aufgrund der technischen und gesellschaftspolitischen Bedingungen geändert. Das hat Einfluss darauf, wie Repositorien gesehen und verwendet werden. Am Beispiel des Repositoriums PHAIDRA der Universität Wien kann diese Entwicklung von einem reinen Datenspeicher bis zu einem gut integrierten Tool in einer forschungsunterstützenden Umgebung nachvollzogen und beschrieben werden.
Improving the User Experience with Audiovisual Content: The Project “Europeana Media”
Authors: Plank Margret , Ogunyemi Abiodun , Réndina Marco , Vanbuel Mathy , Blok Jonathan 
Published: December 2020

Abstract
Europeana is the EU flagship initiative for digital cultural heritage that gives free access to more than 50 million digital objects coming from more than 3,500 libraries, archives and museums across Europe. Of this huge amount of digital cultural heritage content, over a million are videos and more than seven hundred thousand are audio documents. Audio and video materials keep users engaged on a website longer than any other content type and this is the kind of content most web users look for, and user statistics confirm this also on Europeana.eu. Hence the aim of the project Europeana Media was to improve the user experience with audiovisual material on the Europeana portal and deliver functionalities to better access and incorporate AV content from Europeana.eu into the working environments of researchers, educators and citizens by developing an Enhanced Unified Playout Service. This unified player is based on theInternational Image Interoperability Framework (IIIF), which provides a standardised method of describing and delivering images, video and audio over the web.
Data Literacy for Libraries – A Local Perspective on Library Carpentry
Authors: Seidlmayer Eva , Müller Rabea , Förstner Konrad U. 
Published: December 2020

Abstract
In the past decades, libraries have developed into sophisticated information centres. This evolution requires a new set of computational expertises and competencies but also a change in the general attitude toward continuous learning. “Library Carpentry”, as a lesson programme of the “The Carpentries” community offers an elaborate and evidence-based collection of approaches for efficient teaching of the required computational skills and concepts. This article introduces Library Carpentry and presents how it is applied at ZB MED-Information Centre for Life Sciences as a foundation for teaching digital literacy.
Die TIB: Mehr als eine Bibliothek
Authors: Sens Irina , Auer Sören , Bähr Thomas , Niemeyer Sandra , Plank Margret , Schrenk Philip 
Published: December 2020

Zusammenfassung
Die TIB gestaltet aktiv den digitalen Wandel von Bibliotheken mit – in Form von Open Science, Open Access, Forschungsdaten und digitaler Langzeitarchivierung sowie bei der Entwicklung von Diensten an der Schnittstelle von analogen und digitalen Formaten. Sie baut ihre Rolle als deutsches Informationszentrum für die Digitalisierung von Wissenschaft und Technik in Zukunft weiter aus und setzt auf die Entwicklung neuer digitaler Angebote, die klassische bibliothekarische Dienste und innovative Forschungsergebnisse miteinander verzahnen. Als wissenschaftliche Infrastruktureinrichtung steht sie vor zwei großen Herausforderungen: Als Deutsche Zentrale Fachbibliothek für Technik und Naturwissenschaften bewegt sie sich als Akteurin im Zentrum des digitalen Wandels des wissenschaftlichen Arbeitens, des digitalen Publikationswesens und der Globalisierung von Information und Kommunikation. Gleichzeitig erbringt sie als von Bund und Ländern finanzierte Einrichtung verstärkt eigene Forschung.
Streams are my reality. Der Online-Zugang zu Filmen aus Sicht der Filmwissenschaft
Authors: Hagener Malte , Kammerer Dietmar 
Published: December 2020

ZusammenfassungDank der Zunahme an Video-onDemand-Angeboten hat die filmwissenschaftliche Forschung und Lehre einen scheinbar schrankenlosen Zugriff auf ihren zentralen Untersuchungsgegenstand. Allerdings birgt diese neue Situation eine ganze Reihe von Problemen und Herausforderungen, nicht nur in rechtlicher, technischer und organisatorischer Hinsicht, sondern ebenso in methodischer und in filmtheoretischer Perspektive. Der Beitrag benennt und skizziert diese Probleme und verweist auf mögliche Lösungen zur Verbesserung der Lage.
Herausforderung Video-Streaming: Trends und Perspektiven für Öffentliche und wissenschaftliche Bibliotheken
Authors: Bohn Anna , Piguet Michel 
Published: December 2020

Zusammenfassung
Video-Streaming ist weltweit auf dem Vormarsch. Die Covid-19-Pandemie wirkt wie ein Katalysator der bereits seit längerem virulenten Entwicklung hin zum Online-Zugang zu Filmen. Der Beitrag bietet eine erste Bestandsaufnahme wesentlicher Trends des Filmmarkts und untersucht die Auswirkungen auf die Bestandsentwicklung im Bereich audiovisuelle Medien für Öffentliche und wissenschaftliche Bibliotheken im deutschsprachigen Bereich mit Schwerpunkt Deutschland und der Schweiz. Wie wirken sich die umwälzenden Veränderungen des Marktes auf die Arbeitsfelder in Bibliotheken konkret aus und mit welchen Strategien können die Bibliotheken auf die Herausforderungen reagieren? Diskutiert werden Perspektiven wie Konsortienbildung, domänenübergreifende Kooperation mit anderen Kulturerbe-Einrichtungen zur Vernetzung von Daten und Inhalten, gemeinsame Lobbyarbeit für verbesserte rechtliche Regelungen sowie Vereinbarungen mit den Verwertungsgesellschaften.
Themenschwerpunkt Video-Streaming – Editorial
Authors: Bohn Anna 
Published: December 2020

ZusammenfassungDer Themenschwerpunkt Video-Streaming reagiert auf die nachhaltige Bedeutung des Online-Zugangs zu audiovisuellen Ressourcen für den Zugang zu Information, Bildung und Wissen. Er gibt Einblick in eine überaus dynamische laufende Entwicklung in Bibliotheken, Filmarchiven, öffentlich-rechtlichen Fernsehanstalten sowie in der medien- und informationswissenschaftlichen Forschung und Lehre. Der regionale Schwerpunkt liegt auf den Ländern Deutschland, Österreich und der deutschsprachigen Schweiz, der inhaltliche Schwerpunkt auf dem Zugang zu Filmen des internationalen Filmschaffens mit internationaler Distribution. Die Beiträge sind in fünf Abschnitte gegliedert: I. Video-Streaming in Bibliotheken und Zugang zum audiovisuellen Erbe; II. Kooperation mit externen Anbietern von Video-Streaming-Dienstleistungen für Bibliotheken; III. Filmarchive und Zugang zum Filmerbe; IV. Mediatheken öffentlich-rechtlicher Fernsehanstalten und Archivöffnung sowie V. Video-Streaming in Lehre, Forschung und Entwicklung.
Smart automated heart health monitoring using photoplethysmography signal classification
Authors: Raj Remya , Selvakumar Jayakumar , Maik Vivek 
Published: December 2020

Abstract
This paper proposes a smart, automated heart health-monitoring (SAHM) device using a single photoplethysmography (PPG) sensor that can monitor cardiac health. The SAHM uses an Orthogonal Matching Pursuit (OMP)-based classifier along with low-rank motion artifact removal as a pre-processing stage. Major contributions of the proposed SAHM device over existing state-of-the-art technologies include these factors: (i) the detection algorithm works with robust features extracted from a single PPG sensor; (ii) the motion compensation algorithm for the PPG signal can make the device wearable; and (iii) the real-time analysis of PPG input and sharing through the Internet. The proposed low-cost, compact and user-friendly PPG device can also be prototyped easily. The SAHM system was tested on three different datasets, and detailed performance analysis was carried out to show and prove the efficiency of the proposed algorithm.
Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening
Authors: Allaf Bichr , Pondarre Corinne , Allali Slimane , De Montalembert Mariane , Arnaud Cécile , Barrey Catherine , Benkerrou Malika , Benhaim Patricia , Bensaid Philippe , Brousse Valentine , Dollfus Catherine , Eyssette-Guerreau Stéphanie , Galacteros Frédéric , Gajdos Vincent , Garrec Nathalie , Guillaumat Cécile , Guitton Corinne , Monfort-Gouraud Marie , Gouraud François , Holvoet Laurent , Ithier Ghislaine , Kamdem Annie , Koehl Bérengère , Malric Aurore , Missud Florence , Monier Brigitte , Odièvre Marie-Hélène , Joly Philippe , Renoux Céline , Patin Franck , Pissard Serge , Couque Nathalie 
Published: December 2020

Abstract

Objectives
Newborn screening (NBS) for β-thalassemia is based on measuring the expression of the hemoglobin A (HbA) fraction. An absence or very low level of HbA at birth may indicate β-thalassemia. The difficulty is that the HbA fraction at birth is correlated with gestational age (GA) and highly variable between individuals. We used HbA expressed in multiples of the normal (MoM) to evaluate relevant thresholds for NBS of β-thalassemia.

Methods
The chosen threshold (HbA≤0.25 MoM) was prospectively applied for 32 months in our regional NBS program for sickle cell disease, for all tests performed, to identify patients at risk of β-thalassemia. Reliability of this threshold was evaluated at the end of the study.

Results
In all, 343,036 newborns were tested, and 84 suspected cases of β-thalassemia were detected by applying the threshold of HbA≤0.25 MoM. Among the n=64 cases with confirmatory tests, 14 were confirmed using molecular analysis as β-thalassemia diseases, 37 were confirmed as β-thalassemia trait and 13 were false-positive. Determination of the optimum threshold for β-thalassemia screening showed that HbA≤0.16 MoM had a sensitivity of 100% and a specificity of 95.3%, whatever the GA.

Conclusions
NBS for β-thalassemia diseases is effective, regardless of the birth term, using the single robust threshold of HbA≤0.16 MoM. A higher threshold would also allow screening for carriers, which could be interesting when β-thalassemia constitutes a public health problem.
Variability of cycle threshold values in an external quality assessment scheme for detection of the SARS-CoV-2 virus genome by RT-PCR
Authors: Buchta Christoph , Görzer Irene , Chiba Peter , Camp Jeremy V. , Holzmann Heidemarie , Puchhammer-Stöckl Elisabeth , Mayerhofer Maximilian , Müller Mathias M. , Aberle Stephan W. 
Published: December 2020

Abstract

Objectives
The qualitative results of SARS-CoV-2 specific real-time reverse transcription (RT) PCR are used for initial diagnosis and follow-up of Covid-19 patients and asymptomatic virus carriers. However, clinical decision-making and health management policies often are based additionally on cycle threshold (Ct) values (i.e., quantitative results) to guide patient care, segregation and discharge management of individuals testing positive. Therefore, an analysis of inter-protocol variability is needed to assess the comparability of the quantitative results.

Methods
Ct values reported in a SARS-CoV-2 virus genome detection external quality assessment challenge were analyzed. Three positive and two negative samples were distributed to participating test laboratories. Qualitative results (positive/negative) and quantitative results (Ct values) were assessed.

Results
A total of 66 laboratories participated, contributing results from 101 distinct test systems and reporting Ct values for a total of 92 different protocols. In all three positive samples, the means of the Ct values for the E-, N-, S-, RdRp-, and ORF1ab-genes varied by less than two cycles. However, 7.7% of reported results deviated by more than ±4.0 (maximum 18.0) cycles from the respective individual means. These larger deviations appear to be systematic errors.

Conclusions
In an attempt to use PCR diagnostics beyond the identification of infected individuals, laboratories are frequently requested to report Ct values along with a qualitative result. This study highlights the limitations of interpreting Ct values from the various SARS-CoV genome detection protocols and suggests that standardization is necessary in the reporting of Ct values with respect to the target gene.
The unearthed bronze coin molds and the evolution of coin technology in the Warring States period and Qin-Han dynasties
Authors: Huang Juan 
Published: December 2020

Abstract
Coin-minting models and molds can be classified into grand master patterns, master patterns, and casting molds, based on function. The archaeological data available at present show that the bronze coin molds are mainly master patterns and casting molds. This paper makes an as complete as possible collection of archaeologically unearthed bronze molds from the Warring States period to the Qin-Han dynasty, and then classifies them based on coin-minting technology and their functions and forms. After that, the ways to make the molds and to use them to mint coins, as well as the development procedure from vertical mold assembly technology to stack-casting technology are observed. Finally, the social background of the evolution of the coin-minting technology in this period is discussed.
Finite Difference Method on Non-Uniform Meshes for Time Fractional Diffusion Problem
Authors: Qiao Haili , Cheng Aijie 
Published: December 2020

Abstract
In this paper, we consider the time fractional diffusion equation with Caputo fractional derivative. Due to the singularity of the solution at the initial moment, it is difficult to achieve an ideal convergence rate when the time discretization is performed on uniform meshes.
Therefore, in order to improve the convergence order, the Caputo time fractional derivative term is discretized by the

L
⁢
2

-

1
σ

{L2-1_{\sigma}}

format on non-uniform meshes, with

σ
=

1
-

α
2

{\sigma=1-\frac{\alpha}{2}}

, while the spatial derivative term is approximated by the classical central difference scheme on uniform meshes. According to the summation formula of positive integer k power, and considering

k
=

3
,
4
,
5

{k=3,4,5}

, we propose three non-uniform meshes for time discretization. Through theoretical analysis, different time convergence orders

O
⁢

(

N

-

min
⁡

{

k
⁢
α

,
2
}

)

{O(N^{-\min\{k\alpha,2\}})}

can be obtained, where N denotes the number of time splits. Finally, the theoretical analysis is verified by several numerical examples.
Graph automorphisms for compression
Authors: Čibej Uroš , Mihelič Jurij 
Published: December 2020

Abstract
Detecting automorphisms is a natural way to identify redundant information presented in structured data. When such redundancies are detected they can be used for data compression. In this paper we explore two different classes of graphs to capture this intuitive property of automorphisms. Symmetry-compressible graphs are the first class which introduces the basic concepts but use only global symmetries for the compression. In order for this concept to be more practical, we need to use local symmetries. Thus, we extend the basic graph class with Near Symmetry compressible graphs. Furthermore, we develop two algorithms that can be used to compress practical instances and empirically evaluate them on a set of realistic graphs.