bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in West African Summer Monsoon Precipitation Under Stratospheric Aerosol Geoengineering
Authors: Da‐Allada C. Y. , Baloïtcha E. , Alamou E. A. , Awo F. M. , Bonou F. , Pomalegni Y. , Biao E. I. , Obada E. , Zandagba J. E. , Tilmes S. , Irvine P. J. 
Published: June 2020

AbstractStratospheric aerosol geoengineering (SAG) is suggested as a potential way to reduce the climate impacts of global warming. Using simulations from the Geoengineering Large Ensemble project that employed stratospheric sulfate aerosols injection to keep global mean surface temperature and also the interhemispheric and equator‐to‐pole temperature gradients at their 2020 values (present‐day climate) under Representative Concentration Pathway 8.5 scenario, we investigate the potential impact of SAG on the West African Summer Monsoon (WASM) precipitation and the involved physical processes. Results indicate that under Representative Concentration Pathway 8.5, during the monsoon period, precipitation increases by 44.76%, 19.74%, and 5.14% compared to the present‐day climate in the Northern Sahel, Southern Sahel, and Western Africa region, respectively. Under SAG, relative to the present‐day climate, the WASM rainfall is practically unchanged in the Northern Sahel region but in Southern Sahel and Western Africa regions, rainfall is reduced by 4.06% (0.19 ± 0.22 mm) and 10.87% (0.72 ± 0.27 mm), respectively. This suggests that SAG deployed to offset all warming would be effective at offsetting the effects of climate change on rainfall in the Sahel regions but that it would be overeffective in Western Africa, turning a modest positive trend into a negative trend twice as large. By applying the decomposition method, we quantified the relative contribution of different physical mechanisms responsible for precipitation changes under SAG. Results reveal that changes in the WASM precipitation are mainly driven by the reduction of the low‐level land‐sea thermal contrast that leads to weakened monsoon circulation and a northward shift of the monsoon precipitation.
South Atlantic Transect: Variations in Oceanic Crustal Structure at 31°S
Authors: Christeson G. L. , Reece R. S. , Kardell D. A. , Estep J. D. , Fedotova A. , Goff J. A. 
Published: June 2020

AbstractWe present an analysis of geophysical data acquired along a transect of 0–62 Ma crust located on the western flank of the Mid‐Atlantic Ridge at 31°S; all crust was formed at the same ridge segment. Crustal thickness, constrained by five wide‐angle profiles, has mean values of 5.6 km at 6.6 and 15.2 Ma, 7.0 km at 30.6 Ma, 5.5 km at 49.2 Ma, and 3.6 km at 61.2 Ma. Crustal thickness is uniform along each ridge‐parallel profile (standard deviations 0.1–0.3 km), indicating uniform along‐axis magmatic accretion over lateral distances of 40–60 km. The crustal structure of 61.2 Ma crust is not only anomalously thin compared to the other profiles but also contains regions with a linear velocity gradient from seafloor to Moho, which suggests that intense fracturing may extend to the base of the thin crust. Abyssal hill root‐mean‐square heights in the study region are 57–142 m and have an inverse correlation with spreading rate. These values are lower than the average root‐mean‐square height of 196 m elsewhere on the southern Mid‐Atlantic Ridge and indicate relatively high mantle temperatures in our study area. Unsedimented or lightly sedimented basement highs are prevalent at all ages; we argue that bottom currents scour the high topography, transporting sediment into adjacent basement lows. All drillsites planned for International Ocean Discovery Program Expeditions 390 and 393 are within 1–10 km of unsedimented or lightly sedimented basement highs, which should facilitate fluid flow and continued geochemical exchange between crust and seafloor.
Particle‐in‐Cell Experiments Examine Electron Diffusion by Whistler‐Mode Waves: 2. Quasi‐Linear and Nonlinear Dynamics
Authors: Allanson O. , Watt C. E. J. , Ratcliffe H. , Allison H. J. , Meredith N. P. , Bentley S. N. , Ross J. P. J. , Glauert S. A. 
Published: June 2020

AbstractTest particle codes indicate that electron dynamics due to interactions with low amplitude incoherent whistler mode‐waves can be adequately described by quasi‐linear theory. However there is significant evidence indicating that higher amplitude waves cause electron dynamics not adequately described using quasi‐linear theory. Using the method that was introduced in Allanson et al. (2019, https://doi.org/10.1029/2019JA027088), we track the dynamical response of electrons due to interactions with incoherent whistler‐mode waves, across all energy and pitch angle space. We conduct five experiments each with different values of the electromagnetic wave amplitude. We find that the electron dynamics agree well with the quasi‐linear theory diffusion coefficients for low amplitude incoherent waves with (Bw,rms/B0)2≈3.7·10−10, over a time scale T of the order of 1,000 gyroperiods. However, the resonant interactions with higher amplitude waves cause significant nondiffusive dynamics as well as diffusive dynamics. When electron dynamics are extracted and analyzed over time scales shorter than T, we are able to isolate both the diffusive and nondiffusive (advective) dynamics. Interestingly, when considered over these appropriately shorter time scales (of the order of hundreds or tens of gyroperiods), the diffusive component of the dynamics agrees well with the predictions of quasi‐linear theory, even for wave amplitudes up to (Bw,rms/B0)2≈5.8·10−6. Quasi‐linear theory is based on fundamentally diffusive dynamics, but the evidence presented herein also indicates the existence of a distinct advective component. Therefore, the proper description of electron dynamics in response to wave‐particle interactions with higher amplitude whistler‐mode waves may require Fokker‐Planck equations that incorporate diffusive and advective terms.
Height Dependency of Solar Eclipse Effects: The Ionospheric Perspective
Authors: Verhulst Tobias G. W. , Stankov Stanimir M. 
Published: June 2020

AbstractA reliable interpretation of solar eclipse effects on the geospace environment, and on the ionosphere in particular, necessitates a careful consideration of the so‐called eclipse geometry. A solar eclipse is a relatively rare astronomical phenomenon, which geometry is rather complex, specific for each event, and fast changing in time. The standard, most popular way to look at the eclipse geometry is via the two‐dimensional representation (map) of the solar obscuration on the Earth's surface, in which the path of eclipse totality is drawn together with isolines of the gradually‐decreasing eclipse magnitude farther away from this path. Such “surface maps” are widely used to readily explain some of the solar eclipse effects including, for example, the well‐known decrease in total ionization (due to the substantial decrease in solar irradiation), usually presented by the popular and easy to understand ionospheric characteristic of total electron content (TEC). However, many other effects, especially those taking place at higher altitudes, cannot be explained in this fashion. Instead, a more detailed description of the umbra (and penumbra), would be required. This paper addresses the issue of eclipse geometry effects on various ionospheric observations carried out during the total solar eclipse of 21 August 2017. In particular, GPS‐based TEC measurements were analyzed and eclipse effects on the ionosphere are interpreted with respect to the actual eclipse geometry at ionospheric heights. Whenever possible, a comparison was made with results from other eclipse events.
ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis
Authors: Zhao Guangfeng , Li Ruotian , Cao Yun , Song Minmin , Jiang Peipei , Wu Qianwen , Zhou Zhenhua , Zhu Hui , Wang Huiyan , Dai Chenyan , Liu Dan , Yao Simin , Lv Haining , Wang Limin , Dai Jianwu , Zhou Yan , Hu Yali 
Published: June 2020

AbstractEpithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial role in endometrial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63α is associated with fibrosis process and epithelial dysfunction in endometria of patients with intrauterine adhesions (IUAs). Since ΔNp63α is profoundly involved in maintaining the epithelial homeostasis, we hereby focused on its roles in regulating the function and phenotype of endometrial epithelial cells (EECs) in context of endometrial fibrosis. We identified a typical type 2 epithelial-to-mesenchymal transition (EMT) in EECs from IUA patients and this process was induced by the forced expression of ΔNp63α in EECs. In transcriptomic analysis, we found that diverse signaling pathways regulated by ΔNp63α were involved in pro-EMT. We demonstrated that the DUSP4/GSK-3β/SNAI1 pathway was critical in transducing the pro-EMT signals initiated by ΔNp63α, while bFGF reversed ΔNp63α-induced EMT and endometrial fibrosis both in vitro and in vivo by blocking DUSP4/GSK3β/SNAI1 pathway. Taken together, our findings are important to understand the molecular mechanisms of endometrial fibrosis and to provide potential therapeutic targets.
Permo–Triassic boundary carbon and mercury cycling linked to terrestrial ecosystem collapse
Authors: Dal Corso Jacopo , Mills Benjamin J. W. , Chu Daoliang , Newton Robert J. , Mather Tamsin A. , Shu Wenchao , Wu Yuyang , Tong Jinnan , Wignall Paul B. 
Published: June 2020

AbstractRecords suggest that the Permo–Triassic mass extinction (PTME) involved one of the most severe terrestrial ecosystem collapses of the Phanerozoic. However, it has proved difficult to constrain the extent of the primary productivity loss on land, hindering our understanding of the effects on global biogeochemistry. We build a new biogeochemical model that couples the global Hg and C cycles to evaluate the distinct terrestrial contribution to atmosphere–ocean biogeochemistry separated from coeval volcanic fluxes. We show that the large short-lived Hg spike, and nadirs in δ202Hg and δ13C values at the marine PTME are best explained by a sudden, massive pulse of terrestrial biomass oxidation, while volcanism remains an adequate explanation for the longer-term geochemical changes. Our modelling shows that a massive collapse of terrestrial ecosystems linked to volcanism-driven environmental change triggered significant biogeochemical changes, and cascaded organic matter, nutrients, Hg and other organically-bound species into the marine system.
Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India
Authors: Harrison James W. , Tallapragada Divya Sri Priyanka , Baptist Alma , Sharp Seth A. , Bhaskar Seema , Jog Kalpana S. , Patel Kashyap A. , Weedon Michael N. , Chandak Giriraj R. , Yajnik Chittaranjan S. , Oram Richard A. 
Published: June 2020

AbstractType 1 diabetes (T1D) is a significant problem in Indians and misclassification of T1D and type 2 diabetes (T2D) is a particular problem in young adults in this population due to the high prevalence of early onset T2D at lower BMI. We have previously shown a genetic risk score (GRS) can be used to discriminate T1D from T2D in Europeans. We aimed to test the ability of a T1D GRS to discriminate T1D from T2D and controls in Indians. We studied subjects from Pune, India of Indo-European ancestry; T1D (n = 262 clinically defined, 200 autoantibody positive), T2D (n = 345) and controls (n = 324). We used the 9 SNP T1D GRS generated in Europeans and assessed its ability to discriminate T1D from T2D and controls in Indians. We compared Indians with Europeans from the Wellcome Trust Case Control Consortium study; T1D (n = 1963), T2D (n = 1924) and controls (n = 2938). The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs contributed the majority of the discriminative power in Indians. A T1D GRS using SNPs defined in Europeans is discriminative of T1D from T2D and controls in Indians. As with Europeans, the T1D GRS may be useful for classifying diabetes in Indians.
Improved drag coefficient and settling velocity for carbonate sands
Authors: Riazi Amin , Vila-Concejo Ana , Salles Tristan , Türker Umut 
Published: June 2020

AbstractSediment transport calculations are used globally in the numerical models that coastal managers, scientists and engineers use to assess and forecast coastal change. Most of the existing sediment transport equations were defined based on experimental results using siliciclastic sands. Yet these equations are applied to all types of sand, including carbonate sands that have different characteristics and therefore, settling behaviour. A rigorous management of the transport of carbonate sand is essential for the present and future management of sedimentary features in coral reefs such as sandy beaches or reef islands. Here we present a new approach to estimating the drag coefficient of carbonate sands that considers both friction and pressure. Based on our new method, the calculated drag coefficients explain the great variability in settling velocities of carbonate sand observed in nature (from 0.025 m/s to 0.364 m/s in our database). Using our formula, we demonstrate that even small differences in the settling velocity obtained with the new drag coefficient can lead to substantial changes in sediment transport and call for an update of numerical models.
Comparison of phosphor screen autoradiography and micro-pattern gas detector based autoradiography for the porosity of altered rocks
Authors: Delayre C. , Sammaljärvi J. , Billon S. , Muuri E. , Sardini P. , Siitari-Kauppi M. 
Published: June 2020

AbstractThis study aims to further develop the 14C-PMMA porosity calculation method with a novel autoradiography technique, the Micro-pattern gas detector autoradiography (MPGDA). In this study, the MPGDA is compared with phosphor screen autoradiography (SPA). A set of rock samples from Martinique Island exhibiting a large range of connected porosities was used to validate the MPGDA method. Calculated porosities were found to be in agreement with ones from the SPA and the triple-weight method (TW). The filmless nature of MPGDA as well as straightforward determination of C-14 radioactivity from the source rock makes the porosity calculation less uncertain. The real-time visualization of radioactivity from C-14 beta emissions by MPGDA is a noticeable improvement in comparison to SPA.
Spatio-temporal trends in richness and persistence of bacterial communities in decline-phase water vole populations
Authors: Villette Petra , Afonso Eve , Couval Geoffroy , Levret Aurélien , Galan Maxime , Goydadin Anne-Claude , Cosson Jean-François , Giraudoux Patrick 
Published: June 2020

AbstractUnderstanding the driving forces that control vole population dynamics requires identifying bacterial parasites hosted by the voles and describing their dynamics at the community level. To this end, we used high-throughput DNA sequencing to identify bacterial parasites in cyclic populations of montane water voles that exhibited a population outbreak and decline in 2014–2018. An unexpectedly large number of 155 Operational Taxonomic Units (OTUs) representing at least 13 genera in 11 families was detected. Individual bacterial richness was higher during declines, and vole body condition was lower. Richness as estimated by Chao2 at the local population scale did not exhibit clear seasonal or cycle phase-related patterns, but at the vole meta-population scale, exhibited seasonal and phase-related patterns. Moreover, bacterial OTUs that were detected in the low density phase were geographically widespread and detected earlier in the outbreak; some were associated with each other. Our results demonstrate the complexity of bacterial community patterns with regard to host density variations, and indicate that investigations about how parasites interact with host populations must be conducted at several temporal and spatial scales: multiple times per year over multiple years, and at both local and long-distance dispersal scales for the host(s) under consideration.
Spatially-resolved metabolic profiling of living Drosophila in neurodegenerative conditions using 1H magic angle spinning NMR
Authors: Yon Maxime , Decoville Martine , Sarou-Kanian Vincent , Fayon Franck , Birman Serge 
Published: June 2020

AbstractDrosophila flies are versatile animal models for the study of gene mutations in neuronal pathologies. Their small size allows performing in vivo Magic Angle Spinning (MAS) experiments to obtain high-resolution 1H nuclear magnetic resonance (NMR) spectra. Here, we use spatially-resolved 1H high-resolution MAS NMR to investigate in vivo metabolite contents in different segments of the fly body. A comparative study of metabolic changes was performed for three neurodegenerative disorders: two cell-specific neuronal and glial models of Huntington disease (HD) and a model of glutamate excitotoxicity. It is shown that these pathologies are characterized by specific and sometimes anatomically localized variations in metabolite concentrations. In two cases, the modifications of 1H MAS NMR spectra localized in fly heads were significant enough to allow the creation of a predictive model.
Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration
Authors: Uni Rie , Inoue Tsuyoshi , Nakamura Yasuna , Fukaya Daichi , Hasegawa Sho , Wu Chia-Hsien , Fujii Rie , Surattichaiyakul Bongkod , Peerapanyasut Wachirasek , Ozeki Atsuko , Akimitsu Nobuyoshi , Wada Youichiro , Nangaku Masaomi , Inagi Reiko 
Published: June 2020

AbstractThe efficacy of prior activation of an anti-inflammatory pathway called the cholinergic anti-inflammatory pathway (CAP) through vagus nerve stimulation (VNS) has been reported in renal ischemia-reperfusion injury models. However, there have been no reports that have demonstrated the effectiveness of VNS after injury. We investigated the renoprotective effect of VNS in a cisplatin-induced nephropathy model. C57BL/6 mice were injected with cisplatin, and VNS was conducted 24 hours later. Kidney function, histology, and a kidney injury marker (Kim-1) were evaluated 72 hours after cisplatin administration. To further explore the role of the spleen and splenic macrophages, key players in the CAP, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted. VNS treatment significantly suppressed cisplatin-induced kidney injury. This effect was abolished by splenectomy, while adoptive transfer of GTS-21-treated macrophages improved renal outcomes. VNS also reduced the expression of cytokines and chemokines, including CCL2, which is a potent chemokine attracting monocytes/macrophages, accompanied by a decline in the number of infiltrating macrophages. Taken together, stimulation of the CAP protected the kidney even after injury in a cisplatin-induced nephropathy model. Considering the feasibility and anti-inflammatory effects of VNS, the findings suggest that VNS may be a promising therapeutic tool for acute kidney injury.
Dose-dependent pro- or anti-fibrotic responses of endometriotic stromal cells to interleukin-1β and tumor necrosis factor α
Authors: Matsuzaki Sachiko , Pouly Jean-Luc , Canis Michel 
Published: June 2020

AbstractEndometriosis are characterized by dense fibrous tissue. Numerous studies have investigated roles of inflammation on the pathophysiology of endometriosis. However, the interplay of inflammation and fibrosis remains to be clarified. Here we show that low levels of interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNFα) promoted a fibrotic phenotype, whereas high levels of IL-1β and TNFα inactivated the fibrotic phenotype of endometriotic stromal cells (Ectopic-ES). IL-1β 10 pg/mL and TNFα 100 and 1,000 pg/mL had minimal effects, whereas the highest dose of IL-1β (100 pg/mL) significantly decreased collagen gel contraction in Ectopic-ES. Furthermore, in Ectopic-ES, low levels of IL-1β (1 pg/mL) and/or TNFα 10 pg/mL significantly increased Col I mRNA expression, whereas higher doses of IL-1β (10 and/or 100 pg/mL) and/or TNFα (100 and/or 1,000 pg/mL) significantly decreased Col I and/or αSMA mRNA expression and the percentage of cells with Col I + and/or αSMA + stress fibers. In contrast, in either menstrual endometrial stromal cells of patients with endometriosis or those of healthy women, varying doses of IL-1β and/or TNFα had no significant effects on either Col I or αSMA mRNA/protein expression. The present findings bring into question whether we should still continue to attempt anti-inflammatory treatment strategies for endometriosis.
A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
Authors: Luo Wei , He Bin , Han Daiwen , Yuan Lixing , Chen Xinlian , Pang Ling , Tang Jun , Zou Fene , Zhao Kai , Du Yepei , Liu Hongqian 
Published: June 2020

AbstractTo discuss combinations of traditional screening and noninvasive prenatal screening (NIPS) and to compare which traditional screening is the most suitable first-line screening approach to NIPS, pregnant women were recruited in this retrospective observational study. Pregnant women underwent one of four traditional screening tests. The 9 contingent models were combined by high risk cut-offs of 1:50, 1:100, 1:270 and intermediate risk cut-offs of 1:1000, 1:1500, 1:2000. We analyzed cost and performance of various screening models with contingent screening of different risk cut-offs. Compared with other screening tests, combined first-trimester screening (CFTS) had the lowest proportion of high risk (≥1:270) with the highest detection rate (DR) (78.79%) and the lowest proportion of intermediate risk (1:271~1:1000). When intermediate risk was 1:51 ~1:1500, CFTS as first-line screening had the lowest cost with DR of 93.94%. Other screening tests as the first-line screening with intermediate risk of 1:51~1:1000 had the lowest cost, there DR were 90.91%, 84.62%, 91.67%, respectively. Our study demonstrated if only one traditional screening was allowed to screen pregnant women, CFTS was recommended as the first choice. According to local health and economic conditions, adopting appropriate traditional screening with suitable cut-offs as first-line screening will contributed to a cost-effective screening model.