bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study
Authors: Slieker Roderick C , Donnelly Louise A , Fitipaldi Hugo , Bouland Gerard A , Giordano Giuseppe N. , Åkerlund Mikael , Gerl Mathias J. , Ahlqvist Emma , Ali Ashfaq , Dragan Iulian , Festa Andreas , Hansen Michael K. , Aly Dina Mansour , Kim Min , Kuznetsov Dmitry , Mehl Florence , Klose Christian , Simons Kai , Pavo Imre , Pullen Timothy J. , Suvitaival Tommi , Wretlind Asger , Rossing Peter , Lyssenko Valeriya , Quigley Cristina Legido , Groop Leif , Thorens Bernard , Franks Paul W , Ibberson Mark , Rutter Guy A , Beulens Joline WJ , ’t Hart Leen M , Pearson Ewan R 
Published: December 2020

ABSTRACTAims/hypothesisFive clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes (T2D). In the current study we replicate and cross-validate these T2D clusters in three large cohorts using readily measured variables in the clinic.MethodsIn this cross-sectional study, 15,940 individuals were clustered based on age, BMI, HbA1c, random or fasting C-peptide and HDL in three independent cohorts. Clusters were cross-validated against the original clusters based on HOMA measures. In addition, between cohorts, clusters were cross-validated by re-assigning people based on each cohort’s cluster centres.ResultsFive distinct T2D clusters were identified and mapped back to the original four ANDIS clusters. Using C-peptide and HDL instead of HOMA-B and HOMA-S three of the clusters mapped with high sensitivity (80.6 – 90.7%) to the previously identified Severe Insulin Deficient (SIDD), Severe insulin resistant (SIRD) and Obese (MOD) clusters. The previously described ANDIS MARD cluster could be mapped to the two milder groups in our study – one characterised by high HDL, and the other having not any extreme characteristic (MDH cluster). When these two milder groups were combined they mapped well to the previously labelled MARD cluster (sensitivity 79.4%). In the cross-validation between cohorts, particularly the SIDD and MDH cluster cross-validated well with sensitivities ranging from 73.3% to 97.1%. SIRD and MD showed a lower sensitivity ranging from 36.1% to 92.3% where individuals shifted from SIRD to MD and vice versa.Conclusions/interpretationClusters based on C-peptide instead of HOMA measures result in clusters that resemble those based on HOMA measures, especially for SIDD, SIRD and MOD. By adding HDL, the MARD cluster based upon HOMA measures resulted in the current clustering in two clusters with one cluster having high HDL levels. Cross-validation between cohorts showed generally a good resemblance between cohorts. Together, our results show that the clustering based on clinical variables readily measured in the clinic (age, HbA1c, HDL, BMI and C-peptide) results in informative clusters that are representative of the original ANDIS clusters and stable across cohorts.
Risk perception and intelligent decision in complex social information network
Authors: Wu Desheng , Song Jingxiu , Bian Yuan , Zheng Xiaolong , Zhang Zhu 
Published: December 2020

PurposeThe increase of turbulence sources and risk points under the complex social information network has brought severe challenges. This paper discusses risk perception and intelligent decision-making under the complex social information network to maintain social security and financial security.Design/methodology/approachCross-modal semantic fusion and social risk perception, temporal knowledge graph and analysis, complex social network intelligent decision-making methods have been studied. A big data computing platform of software and hardware integration for security combat is constructed based on the technical support.FindingsThe software and hardware integration platform driven by big data can realize joint identification of significant risks, intelligent analysis and large-scale group decision-making.Practical implicationsThe integrated platform can monitor the abnormal operation and potential associated risks of Listed Companies in real-time, reduce information asymmetry and accounting costs and improve the capital market's ability to serve the real economy. It can also provide critical technical support and decision support in necessary public opinion monitoring and control business.Originality/valueIn this paper, the theory of knowledge-enhanced multi-modal multi-granularity dynamic risk analysis and intelligent group decision-making and the idea of an inference think tank (I-aid-S) is proposed. New technologies and methods, such as association analysis, time series evolution and super large-scale group decision-making, have been established. It's also applied in behavior and situation deduction, public opinion and finance and provides real-time, dynamic, fast and high-quality think tank services.
Understanding determinants of social networking service fatigue: an interpretive structural modeling approach
Authors: Xiao Lin , Pan Ting , Mou Jian , Huang Lihua 
Published: December 2020

PurposeThe purpose of this paper is to build a comprehensive structural model to demonstrate the interrelationships of factors influencing social networking service (SNS) fatigue and to identify the varying degrees of influence.Design/methodology/approachA total of 14 factors influencing SNS fatigue are identified through an extensive literature review. Interpretive structural modeling (ISM) and Matrice d'Impacts Croisés Multiplication Appliqué à un Classement (MICMAC) analysis are employed to build a hierarchical model and classify these factors into four clusters.FindingsThe results revealed that ubiquitous connectivity and immediacy of feedback are key factors contributing to SNS fatigue through their strong influence on other factors. Privacy concern, impression management concern and work–life conflict lead directly to SNS fatigue. In contrast, system feature overload and system pace of change are relatively insignificant in generating SNS fatigue.Originality/valueThis study represents an initial step toward comprehensively understanding the interrelationships among the factors leading to SNS fatigue and reveals how determinants of SNS fatigue are hierarchically organized, thus extending existing research on SNS fatigue. It also provides logical consistency in the ISM-based model for SNS fatigue by grouping identified factors into dependent and independent categories. Moreover, it extends the applicability of the integration of the ISM and MICMAC approaches to the phenomenon of SNS fatigue.
The role of environmental management control systems for ecological sustainability and sustainable performance
Authors: Rehman Shafique Ur , Bhatti Anam , Kraus Sascha , Ferreira João J. M. 
Published: December 2020

PurposeThe purpose of this study determines how environmental management control system (MCS) packages influence ecological sustainability and sustainable performance through the mediating role of environmental strategies. Furthermore, this applies organizational capabilities as moderating variables between environmental strategies, ecological sustainability and sustainable performance in a sample of 373 construction firms.Design/methodology/approachThe authors apply quantitative questionnaire data from construction firm representatives (from project, sales and construction managers and contract managers, executive directors and engineers) to structural equation modeling and SmartPLS for our analysis.FindingsThe results demonstrate that recourse to environmental MCS packages significantly influence ecological sustainability, sustainable performance and environmental strategies. Additionally, environmental strategies and organizational capabilities significantly influence ecological sustainability and sustainable performance. Moreover, environmental strategies mediate between environmental MCS packages, ecological sustainability and sustainable performance. Organizational capabilities significantly moderate the relationship between ecological sustainability and sustainable performance.Practical implicationsThis research highlights the issue of how the management of construction organizations deploy environmental MCS packages, organizational capabilities and business strategies to measure ecological sustainability and improve their sustainable performance. This study fills a gap in the literature and facilitates the management of construction organizations in strengthening their internal resources in terms of environmental MCS packages, environmental strategies and organizational capabilities able to help improve their ecological sustainability and sustainable performance.Originality/valueThere are few studies building theoretical frameworks for incorporating environmental MCS packages, organizational capabilities, environmental strategies, ecological sustainability and sustainable performance into a single study. Although the influence of various types of intangible resources on ecological sustainability and sustainable performance receive considerable examination in the literature, there is a dearth of attention paid to understanding the role of environmental MCS packages, environmental strategies and organizational capabilities in determining the ecological sustainability and sustainable performance of construction organizations.
Spatial analysis on the recreation of wool retail spaces in Iranian markets (case study: Tabriz Grand Bazaar)
Authors: Rezaei Nahideh , Najjari Rana , Nezhadfard Arsalan , Mohammadzadeh Rahmat 
Published: December 2020

PurposeThe purpose of this paper aims at the spatial analysis of the Rastas dealing with the wool market to revise the production resulting in a recreation of spaces and the pathways based on its high economic–commercial role.Design/methodology/approachSecondary resources and direct observations through field research were the two critical methodological steps for this paper based on phenomenology and qualitative approaches.FindingsThe results represent that the usage of past experiences is the most effective solutions for activities relying on manufacturing inside the workshops leading to improvement in functional objectives of Bazaar. Integration between diverse institutions, precise planning regarding the creation and restoration of past and new jobs and organizing the exhibition of recreational spaces contributing to development regarding public attraction and strengthening the spatial relationships between production, representation and service. Indeed these mentioned steps will provide multifunctional space with a priority of production and reproduction useful on a recreation of urban life.Originality/valueThis study fulfils to examine the important of the bazaar (Iranian market) and recreate its manufacturing, service and economic processes.
Outcomes of left ventricular assist device implantation for advanced heart failure in critically ill patients (INTERMACS 1 and 2): A retrospective study
Authors: Zhigalov Konstantin , Van den Eynde Jef , Chrosch Thomas , Goerdt Lukas , Sá Michel Pompeu Barros Oliveira , Zubarevich Alina , Papathanasiou Maria , Wendt Daniel , Luedike Peter , Pizanis Nikolaus , Koch Achim , Schmack Bastian , Rassaf Tienush , Kamler Markus , Ruhparwar Arjang , Weymann Alexander 
Published: December 2020

AbstractThe use of left ventricular assist devices (LVADs) for advanced heart failure is becoming increasingly common. However, optimal timing and patient selection remain controversial. The aim of this study was to investigate outcomes of LVAD implantation for advanced heart failure in critically ill patients (INTERMACS 1 and 2). Between August 2010 and January 2020, 207 consecutive patients underwent LVAD implantation. Overall survival, major adverse events, and laboratory parameters were compared between patients in INTERMACS 1‐2 (n = 107) and INTERMACS 3‐5 (n = 100). Preoperative white blood cells, C‐reactive protein, procalcitonin, bilirubin, alanine transaminase, and lactate dehydrogenase were all significantly higher in INTERMACS 1‐2 when compared to INTERMACS 3‐5 (P < .05). During hospitalization following LVAD implantation, patients in INTERMACS 1‐2 were more likely to develop major infections (41.1% vs. 23.0%, P = .005), respiratory failure (57.9% vs. 25.0%, P < .001), mild (20.6% vs. 8.0%, P = .010), and moderate (31.8% vs. 7.0%, P < .001) right heart failure, and acute renal dysfunction (56.1% vs. 6.0%, P < .001). During a median follow‐up of 2.00 years (interquartile range (IQR) 0.24‐3.39 years), they had a higher incidence of thoracic (15.9% vs. 4.0%, P = .005) and gastrointestinal bleeding (21.5% vs. 11.0%, P = .042), as well as right heart failure (18.7% vs. 1%, P < .001). Risk of death was significantly higher in the INTERMACS 1‐2 group (hazards ratio (HR) 1.64, 95% CI 1.12‐2.40, P = .011). LVAD implantation in critically ill patients is associated with increased morbidity and mortality. Our results suggest that decision for LVAD should be not be delayed until INTERMACS 1 and 2 levels whenever possible.
A Modified Double Gyre with Ground Truth Hyperbolic Trajectories for Flow Visualization
Authors: Wolligandt S. , Wilde T. , Rössl C. , Theisel H. 
Published: December 2020

AbstractThe model of a Double Gyre flow by Shadden et al. is a standard benchmark data set for the computation of hyperbolic Lagrangian Coherent Structures (LCS) in flow data. While structurally extremely simple, it generates hyperbolic LCS of arbitrary complexity. Unfortunately, the Double Gyre does not come with a well‐defined ground truth: the location of hyperbolic LCS boundaries can only be approximated by numerical methods that usually involve the gradient of the flow map. We present a new benchmark data set that is a small but carefully designed modification of the Double Gyre, which comes with ground truth closed‐form hyperbolic trajectories. This allows for computing hyperbolic LCS boundaries by a simple particle integration without the consideration of the flow map gradient. We use these hyperbolic LCS as a ground truth solution for testing an existing numerical approach for extracting hyperbolic trajectories. In addition, we are able to construct hyperbolic LCS curves that are significantly longer than in existing numerical methods.
Reliability of evidence‐review methods in restoration ecology
Authors: Romanelli João P. , Meli Paula , Naves Rafaela P. , Alves Marcelo C. , Rodrigues Ricardo R. 
Published: December 2020

AbstractIn restoration science, evidence reviews play a crucial role in summarizing research findings in practice and policy. However, if unreliable or inappropriate methods are used to review evidence, decisions based on these reviews may not accurately reflect the available evidence base. To assess the current value of restoration reviews, we examined a sample of meta‐analyses and narrative syntheses (n = 91) with the Collaboration for Environmental Evidence Synthesis Assessment Tool (CEESAT), which uses detailed criteria to assesses the method of policy‐relevant evidence synthesis according to elements important for objectivity, transparency, and comprehensiveness. Overall, reviews scored low based on this standard: median score 16 out of 39, modal score 15, and mean 16.6. Meta‐analyses scored higher than narrative syntheses (median 17 vs. 5, respectively), although there were some outlier narrative syntheses that had high scores, suggesting that quantitative synthesis does not solely reflect the reliability of a review. In general, criteria spanning the more fundamental review stages (i.e., searching for studies and including studies) received low scores for both synthesis types. Conversely, criteria comprising the later stages of the review (i.e., critical appraisal, data extraction, and data synthesis) were generally well described in meta‐analyses; thus, these criteria achieved the highest individual CEESAT scores. We argue that restoration ecology is well positioned to advance so‐called evidence‐based restoration, but review authors should elucidate their conceptual understanding of evidence syntheses and recognize that conducting reliable reviews demands the same methodological rigor and reporting standards used in primary research. Given the potential of evidence reviews to inform management, policy, and research, it is of vital importance that the overall methodological reliability of restoration reviews be improved.
African Swine Fever threatens Southeast Asia's 11 endemic wild pig species
Authors: Luskin Matthew Scott , Meijaard Erik , Surya Selly , Sheherazade  , Walzer Chris , Linkie Matthew 
Published: December 2020

AbstractThe spread of the most recent African Swine Fever (ASF) outbreak in Asia since late 2018 poses a significant threat to endemic pig species and socioeconomic security. Within domestic pigs and free‐living Eurasian wild boars (bothSus scrofa) in Asia, ASF causes almost 100% case fatality. The ongoing ASF epidemic has so far caused the death of over one hundred million domestic pigs, causing unprecedented economic impacts on the global pork industry. Transmission among free‐living wild boars has been reported, and transmission to threatened Asian pig species is probable but lacks research. Our assessment reveals a near‐term risk for Southeast Asia's 11 endemic pig species, which have small population sizes and small ranges that may be insufficient to withstand the initial, lethal onslaught of the disease. The decline of pigs also triggers cascading impacts for endangered carnivores, plant communities, and livelihoods of millions of people. Our management recommendations include time‐critical research themes, improved emerging infectious disease detection through site‐based monitoring and surveillance paired with online reporting and proper carcass disposal.
Geometry effects on mode I brittle fracture in U‐notched specimens
Authors: Bahadori Robab , Ayatollahi Majid R. , Razavi Nima , Berto Filippo 
Published: December 2020

AbstractThe effects of geometrical constraints on the fracture initiation location and the fracture strength are evaluated in U‐notched specimens using theoretical and experimental analyses. It is proven that high geometrical constraints in pure mode I loading of geometrically symmetric U‐notched specimens can result in occurrence of the maximum tangential stress (MTS) at two symmetric points on both sides of the notch bisector line. The experiments also indicated that the fracture takes place from a direction that is not along the notch bisector line. The experimental results are then examined theoretically through a stress‐based brittle fracture criterion. Because the conventional MTS criterion was poor to predict the onset of fracture properly, an attempt is made to use the generalized MTS (GMTS) criterion by considering the higher order terms in the fracture model. It is shown that the GMTS criterion gives very good predictions for experimentally obtained values of crack initiation angle and notch fracture resistance.
Climate‐driven conifer mortality in Siberia
Authors: Kharuk Viacheslav I. , Im Sergei T. , Petrov Il’ya A. , Dvinskaya Maria L. , Shushpanov Alexandr S. , Golyukov Alexei S. 
Published: December 2020

AbstractAimAn increase in conifer mortality has been observed widely across the boreal forest biome. We investigate the causes of this mortality, in addition to the geospatial and temporal dynamics of mortality, in Siberian pine and fir stands.LocationCentral Siberia.Time period1950–2018.Major taxa studiedPinus sibirica Du Tour and Abies sibirica Ledeb.MethodsWe used geospatial analysis of satellite‐derived (MODIS, Landsat) data, topography (elevation, slope steepness and exposure) and climatic variables [precipitation, thermal degree days (TDD = ∑(t > 0 °C), standardized precipitation evapotranspiration index (SPEI) and root zone moisture content (RZM)], together with in situ data. Dendrochronology was applied for analysis of the radial growth increment (GI).ResultsSiberian pine and fir mortality has increased greatly in recent decades. The mortality of forest stands and trees was dependent on the TDD, RZM and SPEI. Mortality occurred mainly within the southern part of the species ranges and decreased northward, correlated with latitudinal gradients of TDD and SPEI. Mortality was observed mostly at elevations < 1,000 m and decreased with increasing elevation, whereas the area of forests and GI of trees increased with elevation. Forest mortality was preceded by the changes in tree GI. Since the onset of climate warming, GI increased until a breakpoint in the mid‐1980s. Further temperature increase caused a reduction in GI owing to moisture stress and division of the tree population into “decliners” and “survivors”. Mortality was caused by the combined impact of moisture stress and bark beetle attacks.Main conclusionSiberian pine and fir mortality was preceded by a reduction in the GI of trees caused by elevated air temperatures, acute droughts and subsequent insect attacks. Forest mortality was observed mostly at low elevations, whereas within the areas with sufficient moisture availability (at elevations c. < 1,000 m) the tree GI and forest area increased. With the projected increase in drought, Siberian pine and fir trees are predicted to retreat from their southern low‐elevation ranges.
Intersecting marginalities: International students' struggles for “survival” in COVID‐19
Authors: Coffey Julia , Cook Julia , Farrugia David , Threadgold Steven , Burke Penny Jane 
Published: December 2020

AbstractThis article draws on examples from a study of the impacts of coronavirus disease‐2019 (COVID‐19) shutdowns on young hospitality workers in Melbourne and Newcastle, Australia, in May and June of 2020. We explore how existing vulnerabilities related to gender, migrant status, and precarious hospitality work were intensified by the impacts of the COVID‐19 pandemic for young women international students in our study. The international students we discuss were exposed to extreme financial precarity, which rendered them vulnerable to other gendered forms of risk and exploitation, including taking part in experimental drug trails and having to take off‐the‐books cleaning work for a “creep.” These students described feeling “unwelcome” or “unwanted” through open racial discrimination, or comments from the Prime Minister that international students should “go home.” We take an embodied intersectional approach to detail how existing conditions of marginality such as gender, migrant status, economic vulnerability, and precarious conditions of hospitality labor are compounded in the pandemic and exacerbate inequalities, manifesting in increased threats to physical safety and wellbeing.