bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge transfer strategies and practices for higher education institutions
Authors: Cheng Eric C.K. 
Published: March 2020

Purpose
This study aims to identify effective strategies and practices for higher education institutions (HEIs) to enhance their knowledge recipients’ knowledge absorptive capacity.

Design/methodology/approach
Questionnaire surveys and interviews were conducted to examine the effectiveness of a knowledge transfer (KT) project and these were administered by HEIs in Hong Kong. Pre- and post-test questionnaire surveys with t-tests were used to evaluate changes in the knowledge absorptive capacity of 1,014 participants from 20 schools. Qualitative interviews were conducted to investigate school leaders’ perception of the effectiveness of the KT strategies.

Findings
Results revealed significant differences between the pre- and post-tests in all the elements of absorptive capacity. The processes of knowledge acquisition, contextualisation, internalisation and externalisation in a closed-loop mechanism were identified as effective KT strategies. Conducting training programmes, workshops, consultations, work-based studies and presentation seminars were found to be effective KT practices to support the recipients in acquiring, contextualising, internalising and externalising knowledge.

Practical implications
HEIs should provide consultative support to recipients by conducting work-based studies and presentations to enhance their knowledge absorptive capacities.

Originality/value
This study contributes empirical evidence to validate the application of Liyanage et al.’s (2009) KT model to HEIs’ KT model for the purpose of designing KT activities and enhancing the absorption capacities of the recipients. This research contributes an empirical closed-loop KT model, effective KT strategies and practices for HEIs to support their knowledge recipients so that they can internalise the acquired knowledge.
A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer
Authors: Xiang Wanqing , Rao Haiying , Zhou Liyu 
Published: March 2020

BackgroundTo identify the performance of contrast‐enhanced spectral mammography (CESM) and magnetic resonance imaging (MRI) for breast cancer diagnosis by pooling the open published data.MethodsA systematic review of studies relevant to CESM and MRI in the diagnosis of breast cancer were screened in the electronic databases of Pubmed, EMBASE, the Cochrane Library, Web of Science, Google scholar and CNKI. The methodical quality of the included publications was evaluated by the quality assessment of diagnostic accuracy studies‐2 (QUADAS‐2). The diagnostic sensitivity, specificity and area under the ROC curve (AUC) were pooled and the true positive (TP), false positive (FP), false negative (FN) and true negative (TN) of the original studies were calculated.ResultsA total of 13 diagnostic publications were identified and included in the meta‐analysis. Of those included, five were retrospective studies and the remaining eight were prospective work. The combined data indicating the pooled sensitivity and specificity of CESM and MRI were 0.97 (95% CI: 0.95–0.98), 0.66 (95% CI: 0.59–0.71), 0.97 (95% CI: 0.95–0.98),and 0.52 (95% CI: 0.46–0.58), respectively. The pooled +LR and –LR for CESM were 2.70 (95% CI: 1.57–4.65), 0.06 (95% CI: 0.04–0.09), and 2.01 (95% CI: 1.78–2.26), 0.08 (95% CI: 0.05–0.11) for MRI, respectively. For the diagnostic odds ratio (DOR), the pooled results of CESM and MRI were 60.15 (95% CI: 24.72–146.37) and 31.34 (95% CI: 19.61–50.08), respectively. The AUC of the symmetric receiver operating characteristic curve (SROC) was 0.9794 and 0.9157 for CESM and MRI, respectively, calculated using the Moses model in the diagnosis of breast cancer.ConclusionsBoth CESM and MRI are effective methods for the detection of breast cancer with high diagnostic sensitivity. The diagnostic performance of CESM appears to be more effective than MRI.
Thousands of missing variants in the UK Biobank are recoverable by genome realignment
Authors: Jia Tongqiu , Munson Brenton , Lango Allen Hana , Ideker Trey , Majithia Amit R. 
Published: March 2020

AbstractThe UK Biobank is an unprecedented resource for human disease research. In March 2019, 49,997 exomes were made publicly available to investigators. Here we note that thousands of variant calls are unexpectedly absent from this dataset, with 641 genes showing zero variation. We show that the reason for this was an erroneous read alignment to the GRCh38 reference. The missing variants can be recovered by modifying read alignment parameters to correctly handle the expanded set of contigs available in the human genome reference. Given the size and complexity of such population scale datasets, we propose a simple heuristic that can uncover systematic errors using summary data accessible to most investigators.
Emergency surgery versus elective surgery after reduction for patients with incarcerated groin hernias
Authors: Kohga Atsushi , Kawabe Akihiro , Yajima Kiyoshige , Okumura Takuya , Yamashita Kimihiro , Isogaki Jun , Suzuki Kenji 
Published: March 2020

AbstractBackgroundThe feasibility and potential advantages of elective surgery after manual reduction of incarcerated hernia (IH) have not been investigated in detail. Therefore, the aim of this retrospective study was to compare perioperative outcomes of emergency surgery to those of elective surgery after reduction of IH.MethodsA total of 112 patients were preoperatively diagnosed with IH between January 2010 and April 2019. Patients were divided into an emergency group (76 patients underwent emergency surgery: 21 patients received intestinal resection and 55 patients did not) and a reduction group (36 patients underwent elective surgery after reduction and none required intestinal resection). The outcomes between the groups were compared. A subgroup analysis was also performed on the patients who did not require intestinal resection.ResultsIn patients who did not undergo intestinal resection, the post‐operative length of stay was significantly shorter in the reduction group than in the emergency group (8.0 versus 4.3 days, P < 0.001). The percentage of mesh prosthesis cases was significantly higher in the reduction group (74.4% versus 100%, P = 0.001). The incidence of post‐operative complications was significantly lower in the reduction group (45.4% versus 13.8%, P < 0.001). In all 112 patients, femoral hernia (P = 0.013, odds ratio = 4.76) and emergency surgery (P = 0.008, odds ratio = 4.49) were found to be independent risk factors for developing post‐operative complications.ConclusionsElective surgery after reduction showed more favourable outcomes in selected patients. Moreover, emergency surgery was an independent predictor for post‐operative complications.
Sexual dimorphism in size and shape in the viviparous lizard Abronia taeniata (Squamata: Anguidae) in central Mexico
Authors: Cruz‐Elizalde Raciel , Villamar‐Duque Tomás E. , Ramírez‐Bautista Aurelio 
Published: March 2020

AbstractIn the present study, we analyse sexual dimorphism in size and shape of morphological attributes in a population of Abronia taeniata in central Mexico. The variables analysed were snout–vent length (SVL), head length (HL), head width (HW), head height (HH), tibia length (TL) and femur length (FL). In the size attributes, males and females had similar SVL, and males were larger in the rest of the variables analysed (HL, HW, HH and FL), except TL. In the case of shape, the females had larger dimensions in the relative logSVL variable, and the males were larger in the relative logHL, relative logHW and relative logHH variables. The variables relative logFL and relative logTL showed no sexual shape dimorphism. The similarity in the sizes and the sexual dimorphism between sexes in attributes of the head and extremities are explained by the hypothesis of sexual selection directed to the structures of the head in males, and in the case of shape in females, to the fecundity hypothesis. Comparative studies that analyse a greater number of morphological variables are necessary to determine the factors that promote the different patterns of sexual dimorphism in the group.
Efficacy and safety of humanized anti‐CD19‐CAR‐T therapy following intensive lymphodepleting chemotherapy for refractory/relapsed B acute lymphoblastic leukaemia
Authors: Wang Jia , Mou Nan , Yang Zhenxing , Li Qing , Jiang Yanyu , Meng Juanxia , Liu Xuxiang , Deng Qi 
Published: March 2020

SummaryWe studied the efficacy and safety of humanized CAR‐T therapy following intensive chemotherapy for refractory/relapsed (R/R) acute lymphoblastic leukaemia (B‐ALL). Twenty‐three patients with R/R B‐ALL were pretreated with intensive chemotherapy (fludarabine combined with medium‐dose cytarabine) 12 days before CAR‐T therapy. Adverse events (AEs), curative effects, infection indicators and cytokine release syndrome (CRS) were monitored. Each of the 23 patients received a dose of 1·0 × 106 cells/kg CAR‐T cell infusion on day 0. After 14 days, 19 patients (82·61%) achieved complete response (CR) or CR with incomplete count recovery. No survival benefit was achieved with consolidative haematopoietic stem‐cell transplantation (HSCT), with a median follow‐up of 14·0 months (range, 1·5–21·0 months). The notable AEs were grade 1–2 CRS in 18 patients, while the other five patients were grade 3 CRS. No patients died of CRS. Only one patient died of respiratory failure due to cytomegalovirus infection 24 days after infusion. The proportion of leukaemic cells in bone marrow on infusion day and the peaks of IL‐6, TNF‐α and IL‐8 levels were correlated with CRS levels. A lower disease burden was achieved by intensive lymphodepleting chemotherapy, and the subsequent CAR‐T therapy had a high response and manageable toxicity.Trial registration: The patients were enrolled in a clinical trial of ChiCTR‐ONN‐16009862, and ChiCTR1800019622.
Emotional Maltreatment and Adolescent Depression: Mediating Mechanisms and Demographic Considerations in a Child Welfare Sample
Authors: McNeil Shiesha L. , Andrews Arthur R. , Cohen Joseph R. 
Published: March 2020

Emotional maltreatment is a risk factor for adolescent depression. Yet, it remains unclear whether commissions and omissions of emotional maltreatment (a) confer vulnerability via distinct mechanisms and (b) demonstrate similar risk across adolescent subpopulations. The present, multiwave study examined whether school engagement and peer relationships explain the depressive effects of distinct emotional maltreatment subtypes in an at‐risk child welfare sample (N = 657; ages 11–14, AgeMean = 12.49). The findings indicated that commission subtypes of emotional maltreatment predicted increasing depressive symptoms via increasing peer relationship problems, especially for girls. Meanwhile, decreasing school engagement was a depressogenic risk pathway for Hispanic adolescents reporting omission subtypes of emotional maltreatment. The results emphasize the importance of distinguish between emotional maltreatment subtypes to identify specific risk pathways for adolescent depression.
Perivenous demyelination: Association with anti‐myelin oligodendrocyte glycoprotein antibody
Authors: Misu Tatsuro , Takai Yoshiki , Takahashi Toshiyuki , Nakashima Ichiro , Fujihara Kazuo , Aoki Masashi 
Published: March 2020

AbstractBy the discovery of an antibody to aquaporin 4 (AQP4), the clinical and radiological findings of neuromyelitis optica (NMO) such as diffuse cerebral or longitudinally extended spinal cord lesions had been clarified as distinct features from multiple sclerosis (MS). Pathological studies in NMO demonstrated loss of immunoreactivity to AQP4 and glial fibrillary acidic protein but a relative preservation of myelin basic protein, especially at the lesions with perivascular deposition of immunoglobulins and complements, suggesting autoimmune disease against astrocytes. In recent years, the antibody against myelin oligodendrocyte glycoprotein (MOG) has been studied for its association with acute demyelinating diseases such as acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM), optic neuritis, AQP4 antibody–negative NMOSD, and brainstem or cerebral cortical encephalomyelitis. We could identify the dominance of perivenous inflammatory demyelination like ADEM in our biopsied case series with MOG antibody. In recent brain‐biopsied cases with MOG antibody, the deposition of humoral immunity, perivascular inflammation, and perivenous demyelination were observed especially in atypical cases including cortical encephalitis or disseminated encephalitis. In this review, we focus on MOG antibody–related diseases, which we considered it as a differentiated disease from MS by means of the disease‐specific autoantibody and the distinct pathophysiology.
Anti‐plexin D1 antibody–mediated neuropathic pain
Authors: Fujii Takayuki , Yamasaki Ryo , Miyachi Yukino , Iinuma Kyoko , Kira Jun‐ichi 
Published: March 2020

AbstractNeuropathic pain (NeP) is an intractable pain caused by a lesion or disease of the somatosensory nervous system. NeP is often challenging to manage because most of the mechanisms remain to be elucidated. Recent investigations in the field of autoimmune neurology have demonstrated that specific autoantibodies against antigens in the somatosensory pathway can cause NeP. Detection of pathogenic autoantibodies in NeP adds to the understanding of the mechanism of pain, which might aid in the development of novel immunotherapies. Therefore, it is necessary to explore novel NeP‐related autoantibodies to improve the management of intractable pain. Recently, we screened serum autoantibodies that bound to pain‐conducting small dorsal root ganglion (DRG) neurons and their nerve terminals in the dorsal horns of NeP patients. We detected a novel autoantibody that bound to unmyelinated C‐fiber–type small DRG neurons. The positive rate in patients with NeP was 10%. We identified plexin D1 as the target antigen. NeP patients with plexin D1‐IgG developed burning pain and thermal hyperalgesia. The main comorbidities were allergy, collagen vascular disease, and cancer. Plasma exchange and intravenous methylprednisolone pulse therapy are effective for NeP in patients with plexin D1‐IgG, indicating that these autoantibodies might be pathogenic in NeP. Indeed, our in vitro study demonstrated that plexin D1‐IgG induced the membrane hyperpermeability of DRG neurons. In this review, we describe the discovery of plexin D1‐IgG and discuss the association between plexin D1 and pain, allergy, and cancer.
Comprehensive intervention during pregnancy based on short message service to prevent or alleviate depression in pregnant women: A quasi‐experimental study
Authors: Gong Meiqian , Zhang Sheng , Xi Chuhao , Luo Min , Wang Tian , Wang Yingxiang , Wang Songbai , Guo Lan , Lu Ciyong 
Published: March 2020

AbstractAimWomen have an increased risk for developing depression during pregnancy, and depression has a serious negative impact on the mother and infant. This study explored the effectiveness and feasibility of a comprehensive intervention based on using a short message service (SMS) to reduce depressive symptoms and prevent depression during pregnancy.MethodsThis quasi‐experimental study was conducted in three public hospitals with similar levels of care and maternal origin in Jiangmen City, Guangdong Province. One of the three hospitals was randomly selected as the intervention hospital, and the others were control hospitals. There were 4501 pregnant women who participated in this study. Pregnant women in the intervention group received a comprehensive intervention based on SMS after enrollment. Data were collected using questionnaires from August 2016 to August 2018.ResultsAfter the intervention, the Edinburgh Postnatal Depression Scale scores of the intervention group were lower than those of the control group (intervention group: 3.9 ± 3.9, control group: 5.2 ± 4.3, P < .001), and the proportion of subjects with positive depression screening results in the intervention group was also significantly lower than that in the control group (intervention group: 9.0%, control group: 16.1%, P < .001). Moreover, compared with women in the intervention group, women in the control group who did not receive the intervention were more likely to be positive for depression in the third trimester (AOR = 2.04, 95% CI = 1.62‐2.58).ConclusionsThe SMS‐based comprehensive intervention used in this study can effectively alleviate depressive symptoms and reduce the risk of depression during pregnancy.
In defence of the hearing? Emerging geographies of publicness, materiality, access and communication in court hearings
Authors: Hynes Jo , Gill Nick , Tomlinson Joe 
Published: March 2020

AbstractThe shift towards dispute resolution taking place outside traditional legal arenas is fundamentally changing the relationship between space and law, presenting legal geography with pressing new research opportunities. This paper explores how the emerging geographies of publicness, materiality, access to justice and communication shed light on the consequences of alternative and online dispute resolution. Crucially, these consequences raise urgent interdisciplinary questions for geography and law. We set out these questions and suggest that legal geography will be best placed to address them by working through some of the practical, applied ramifications of its concepts and perspectives.
Comparison of two perioperative antibiotic schedules in patients undergoing surgical reconstruction with dermal matrix after excision of skin cancer
Authors: Fiorentini Chiara , Bedini Andrea , Mandel Victor Desmond , Bacca Erica , Menozzi Marianna , Reggiani Camilla , De Pace Barbara , Meschiari Marianna , Santoro Antonella , Franceschini Erica , Mussini Cristina , Terrenato Irene , Giacomelli Luca , Magnoni Cristina 
Published: March 2020

AbstractPerioperative antibiotic treatment duration in skin reconstruction with dermal substitutes is not well established. This study compares the incidence of infective complications after two different durations of perioperative antibiotic treatment in patients undergoing surgical reconstruction with skin dermal substitutes (SDS) after excision of skin cancer. Infective complications at the site of SDS were compared in subjects undergoing surgical reconstruction who received either a > 24‐hour (extended protocol) or a ≤ 24‐hour (short protocol) perioperative antibiotic treatment. Of 116 patients undergoing SDS surgical reconstruction, 62 (53.4%) received an extended schedule, and 54 (46.6%) received a short schedule. The two groups were similar for gender, age, comorbidities, American Society of Anesthesiologists score, and type of skin cancer. Overall incidence rate of infection was 20.7% (24/116). No differences in terms of risk of infection were observed between the two groups (OR: 1.04, 95% CI: 0.42‐2.55; P = .937). Patients undergoing SDS reconstruction in the limb/foot had a higher risk of infection in comparison with those undergoing SDS reconstruction in the chest/head (OR: 2.69, 95% CI: 1.06‐6.86; P = .038). The short protocol was demonstrated to be beneficial to patients undergoing surgical reconstruction with SDS. A ≤ 24‐hour perioperative antibiotic schedule did not increase the infection rate, potentially allowing a reduction of antibiotic exposure.
Enhanced photothermal conversion performances with ultra‐broad plasmon absorption of Au in Au/Sm2O3 composites
Authors: Yu Yang , Xu Sai , Gao Yuefeng , Jiang Muhan , Li Xiangping , Zhang Jinsu , Zhang Xizhen , Chen Baojiu 
Published: March 2020

AbstractLanthanide oxides are ideal candidates as photothermal conversion agents owing to their larger photon energy and advantages in biomedical applications. However, the small absorption cross section of rare earth is not conducive of absorbing near infrared light, which will affect the photothermal conversion efficiency of lanthanide oxides. Herein, Au particles are successfully introduced into Sm2O3 to form Au/Sm2O3 composites. The investigation of broadband emission and thermal performances in Sm2O3 and Au/Sm2O3 composites confirm the ultra‐broad plasmon absorption of Au induced thermal effect is in favor of the formation of broadband emission, meanwhile, enhances the photothermal conversion capability of Au/Sm2O3 composites. The temperature increases of the Au/Sm2O3 composites are 5.5°C and 19.6°C compared to Sm2O3 particles under the irradiation of near infrared laser with power density of 11.5 and 29.0 mW/mm2, respectively. In additional, the enhanced photothermal conversion effect is confirmed by the alcohol volatilization experiment and visual infrared thermal images. We present here an idea for enhancing the photothermal conversion capabilities of lanthanide oxides and highlight the promise of using this kind of materials for photothermal therapy.
Indexicality and the Indigenization of Politics: Dancer–Pilgrims Protesting Mining Concessions in the Andes
Authors: Salas Carreño Guillermo 
Published: March 2020

ResumenEl santuario de Quyllurit'i, ubicado al pie de un glaciar a setenta kilómetros de la ciudad del Cuzco, es el foco de la peregrinación más grande de los Andes peruanos. Este artículo analiza una protesta organizada por el Consejo de Naciones Peregrinas del Señor de Qoyllurit'i en la ciudad del Cuzco, reclamando la cancelación de concesiones mineras contiguas al santuario. Si bien los danzantes‐peregrinos no reclaman ser indígenas, sus performances en la protesta estuvieron fuertemente cargadas de índices de indigeneidad enmarcados en las ideologías étnico‐raciales regionales. La protesta obtuvo el apoyo de las autoridades regionales a través de una performance obvia pero implícita de indigeneidad, que también supuso desafíos a la política hegemónica que excluye a los no‐humanos. El artículo resalta cómo múltiples formas de indigeneidad, que emergen primariamente a través de la indexicalidad, pueden intervenir notoriamente en política, pero también cómo la influencia política del Consejo de Naciones depende de su abstención en participar activamente en la política formal. [indigeneidad, performance, orden indexical, protesta contra la minería, cosmopolítica]
Investing in Public School Kitchens and Equipment as a Pathway to Healthy Eating and Equitable Access to Healthy Food
Authors: O'Neill Moira , Mujahid Mahasin , Hutson Malo , Fukutome Amanda , Robichaud Raine , Lopez Jaime 
Published: March 2020

ABSTRACTBACKGROUNDWe gathered baseline data about student need of healthy, free school food, and if current school meal programming serves students in need of healthy free school food, in anticipation of the completion of a district‐wide kitchen infrastructure and educational farm project in a high‐poverty urban school district.METHODSWe used mixed methods to assess student hunger, whether the school meal program met student needs, and to determine associations between presence of a cooking kitchen and perceptions of healthy food. Participants included 72 staff, 143 parents, and 6437 K‐5 students in the qualitative component, and 9078 parents and 1693 staff in the quantitative component.RESULTSStaff participants stated packaging and reheating food influenced student consumption. During observations, students at seven of nine high poverty sites with packaged reheated food did not eat school meals, but this was not true at four out of four high‐poverty sites with unpackaged fresh food. Parents (OR = 1.17, 95% CI 1.00‐1.39) and staff (OR = 1.58, 95% CI 1.15‐2.17) from schools with a cooking kitchen were more likely to perceive school lunch as healthy in adjusted models.CONCLUSIONSFood preparation and presentation appears to influence student consumption of school food and adult perception of school meal quality.