bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of quality of care of patients with ST-segment elevation myocardial infarction
Authors: Hudzik Bartosz , Budaj Andrzej , Gierlotka Marek , Witkowski Adam , Wojakowski Wojciech , Zdrojewski Tomasz , Gil Robert , Legutko Jacek , Bartuś Stanisław , Buszman Paweł , Dudek Dariusz , Gąsior Mariusz 
Published: November 2019

Aims:The 2017 European Society of Cardiology guidelines for the management of ST-elevation myocardial infarction recommended assessing quality of care to establish measurable quality indicators in order to ensure that every ST-elevation myocardial infarction patient receives the best possible care. We investigated the quality indicators of healthcare services in Poland provided to ST-elevation myocardial infarction patients.Methods and results:The Polish Registry of Acute Coronary Syndromes is a nationwide, multicentre, prospective study of acute coronary syndrome patients in Poland. For the purpose of assessing quality indicators, we included 8279 patients from the Polish Registry of Acute Coronary Syndromes hospitalised with ST-elevation myocardial infarction in 2018. Four hundred and eight of 8279 patients (4.9%) arrived at percutaneous coronary intervention centre by self-transport, 4791 (57.9%) arrived at percutaneous coronary intervention centre by direct emergency medical system transport, and 2900 (37.2%) were transferred from non-percutaneous coronary intervention facilities. Whilst 95.1% of ST-elevation myocardial infarction patients arriving in the first 12 h received reperfusion therapy, the rates of timely reperfusion were much lower (ranging from 39.4% to 55.0% for various ST-elevation myocardial infarction pathways). The median left ventricular ejection fraction was 46% and was assessed before discharge in 86.0% of patients. Four hundred and eighty-nine of 8279 patients (5.9%) died during hospital stay. Optimal medical therapy is prescribed in 50–85% of patients depending on various clinical settings. Only one in two ST-elevation myocardial infarction patients is enrolled in a cardiac rehabilitation program at discharge. No patient-reported outcomes were recorded in the Polish Registry of Acute Coronary Syndromes.Conclusions:The results of this study identified areas of healthcare system that require solid improvement. These include direct transport to percutaneous coronary intervention centre, timely reperfusion, guidelines-based medical therapy (in particular in patients with heart failure), referral to cardiac rehabilitation/secondary prevention programs. Also, there is a need for recording quality indicators associated with patient-reported outcomes.
Prioritizing candidate diseases-related metabolites based on literature and functional similarity
Authors: Wang Yongtian , Juan Liran , Peng Jiajie , Zang Tianyi , Wang Yadong 
Published: November 2019

Abstract
Background
As the terminal products of cellular regulatory process, functional related metabolites have a close relationship with complex diseases, and are often associated with the same or similar diseases. Therefore, identification of disease related metabolites play a critical role in understanding comprehensively pathogenesis of disease, aiming at improving the clinical medicine. Considering that a large number of metabolic markers of diseases need to be explored, we propose a computational model to identify potential disease-related metabolites based on functional relationships and scores of referred literatures between metabolites. First, obtaining associations between metabolites and diseases from the Human Metabolome database, we calculate the similarities of metabolites based on modified recommendation strategy of collaborative filtering utilizing the similarities between diseases. Next, a disease-associated metabolite network (DMN) is built with similarities between metabolites as weight. To improve the ability of identifying disease-related metabolites, we introduce scores of text mining from the existing database of chemicals and proteins into DMN and build a new disease-associated metabolite network (FLDMN) by fusing functional associations and scores of literatures. Finally, we utilize random walking with restart (RWR) in this network to predict candidate metabolites related to diseases.

Results
We construct the disease-associated metabolite network and its improved network (FLDMN) with 245 diseases, 587 metabolites and 28,715 disease-metabolite associations. Subsequently, we extract training sets and testing sets from two different versions of the Human Metabolome database and assess the performance of DMN and FLDMN on 19 diseases, respectively. As a result, the average AUC (area under the receiver operating characteristic curve) of DMN is 64.35%. As a further improved network, FLDMN is proven to be successful in predicting potential metabolic signatures for 19 diseases with an average AUC value of 76.03%.

Conclusion
In this paper, a computational model is proposed for exploring metabolite-disease pairs and has good performance in predicting potential metabolites related to diseases through adequate validation. This result suggests that integrating literature and functional associations can be an effective way to construct disease associated metabolite network for prioritizing candidate diseases-related metabolites.
Extracting a biologically latent space of lung cancer epigenetics with variational autoencoders
Authors: Wang Zhenxing , Wang Yadong 
Published: November 2019

Abstract
Background
Lung cancer is one of the most malignant tumors, causing over 1,000,000 deaths each year worldwide. Deep learning has brought success in many domains in recent years. DNA methylation, an epigenetic factor, is used for model training in many studies. There is an opportunity for deep learning methods to analyze the lung cancer epigenetic data to determine their subtypes for appropriate treatment.

Results
Here, we employ variational autoencoders (VAEs), an unsupervised deep learning framework, on 450K DNA methylation data of TCGA-LUAD and TCGA-LUSC to learn latent representations of the DNA methylation landscape. We extract a biologically relevant latent space of LUAD and LUSC samples. It is showed that the bivariate classifiers on the further compressed latent features could classify the subtypes accurately. Through clustering of methylation-based latent space features, we demonstrate that the VAEs can capture differential methylation patterns about subtypes of lung cancer.

Conclusions
VAEs can distinguish the original subtypes from manually mixed methylation data frame with the encoded features of latent space. Further applications about VAEs should focus on fine-grained subtypes identification for precision medicine.
Oral adherence in adults with acute myeloid leukemia (AML): Results of a mixed methods study.
Authors: Bryant Ashley Leak , LeBlanc Thomas William , Albrecht Tara A. , Chan Ya-Ning , Richardson Jaime , Foster Matthew C. , Dang Malisa , Owenby Susie , Wujcik Debra 
Published: November 2019

105 Background: The incidence of AML is increasing, in part due to an aging population. Amid established intravenous (IV) or subcutaneous chemotherapies , recent drug approvals have ushered in an era of oral medication (OM) approaches to treating AML, shifting the burden of daily adherence from clinicians to patients. We aimed to identify and summarize adherence to oral therapy in this population. Methods: Our mixed methods study design used focus groups (FG) and patient surveys. After IRB approval, 11 patients and 4 caregivers participated in 4 focus groups. Results were used to develop a 37-item OM adherence needs assessment. Subsequently, AML patients were recruited and consented at three cancer centers to complete surveys (online, at the clinic, hospital, or from home). Results: 100 patients completed the OM survey. Most were male (62%), racial/ethnic diversity (33%), < 65 years (59%), and college-educated (52%). The to be taken was the most frequent and troublesome challenge. Loss of appetite was the most commonly reported and problematic side effect. Although half of the patients stated, “no side effect would cause them to stop taking OM”, another 25% indicated nausea would cause non-adherence. The best strategy to support taking OM was to make it part of the daily routine. Directions for taking OM were most commonly found on medication bottles or received from the health care team (HCT); patients felt HCTs were the best source of directions. Nearly 1/3 of patients indicated they skip the OM dose altogether when they forget to take it. When asked what would help improve adherence: smaller pills, easier packaging, and scheduling assistance were most frequently reported. Older individuals (>65 years) had a slightly more positive attitude towards oral medication (p =.51). Younger patients (<65 years) were more accepting of taking oral vs IV meds, (p = .03). Conclusions: This study represents the first assessment of OM adherence in patients with AML. Three themes emerged in FG transcript analysis that informed the development of a 37-item survey that was subsequently completed by 100 patients. Findings provide the basis for further exploration of interventions to enhance and increase adherence to OM regimens.
Anxiety, depression, pain, and social support in a large representative cancer population.
Authors: Galloway Sarah Kathryn , Meadors Patrick , Boselli Danielle , Walsh Declan 
Published: November 2019

76 Background: Pain is one of the most common cancer symptoms. Individuals in pain often experience psychological distress in the form of anxiety and depression. Social support is an important resource utilized by patients to cope with cancer. Aims: (1) Identify clinicodemographic factors influencing cancer pain; (2) examine social support as a moderator of the relation between anxiety, depression and cancer pain. Methods: Participants included stage I-IV cancer patients (N = 11,815) who completed a routine tablet-based psychosocial distress screening at a large academic hybrid, multi-site, community-based cancer institute (Jan 2017- Jan 2019). Participants were matched to the Cancer Registry (N = 7,333); clinicodemographic factors were incorporated into lasso regression models. Models identified pain predictors from self-reported anxiety, depression and social support. Analyses examined if the effect of anxiety and depression on pain differed by levels of social support. Results: Median age was 59 (RNG, 18-101), 61% female and 77% white. Tumor site (GI, Gyn, head/neck), advanced disease, black race, and lower income were independently associated with severe pain. Anxiety (β = 0.48, p < .001) and depression (β = 0.69, p < 0.001) were related to pain intensity after accounting for clinicodemographic factors. The effect of depression on pain differed by level of social support (p = 0.009). The effect of anxiety on pain differed in patients reporting transportation issues (p = 0.035). Conclusions: This is the largest study to date examining cancer pain intensity, psychological factors of anxiety and depression, and social support. Our data suggests that patient characteristics of race, income, tumor site, and disease staging independently predict pain intensity. Anxiety and depression are significant factors of pain intensity; these associations remain after accounting for patient characteristics. Social support buffers the negative impact of anxiety/depression on pain. Clinicians who treat cancer pain should be attuned to modifiable psychological factors which can greatly influence a patient’s pain experience. Findings emphasize the need for interdisciplinary multimodal approaches for cancer pain.
Sleep Deprivation: Cytokine and Neuroendocrine Effects on Perception of Effort
Authors: CULLEN TOM , THOMAS GAVIN , WADLEY ALEX J. 
Published: November 2019

ABSTRACTIntroductionAn increased perception of effort and subjective fatigue are thought to be central to decreased exercise performance observed after disrupted sleep. However, there is limited understanding of mechanisms that underpin these phenomena. We investigated the role of interleukin-6 (IL-6), the soluble IL-6 receptor, and neuroendocrine factors (cortisol, adrenaline, noradrenaline, and brain-derived neurotropic factor) in mediating these responses at rest and during exercise.MethodsIn a randomized order, 10 healthy active men completed three experimental trials following different sleep conditions: a single night of sleep deprivation, partial sleep deprivation equivalent to 4 h of sleep, and normal sleep. The experimental sessions consisted of physiological and perceptual measurements of exercise intensity throughout 45-min moderate intensity and 15-min maximal effort cycling. Cytokine and neuroendocrine factors were assessed at rest and in response to exercise.ResultsSleep deprivation resulted in increased resting IL-6, lower blood glucose, increased perceived fatigue and perception of effort, lower free-living energy expenditure, and reduced maximal exercise performance. In contrast, sleep deprivation did not alter physiological, cytokine, or neuroendocrine responses to exercise. Variations in the resting concentration of IL-6 were associated with lowered blood glucose, an increased perception of effort, and impaired exercise performance. Resting concentrations of cortisol, adrenaline, noradrenaline, and BNDF showed subtle interactions with specific aspects of mood status and performance but were not affected by sleep deprivation. There were minimal effects of partial sleep deprivation.ConclusionsThese findings demonstrate that cytokine and neuroendocrine responses to exercise are not altered by sleep deprivation but that changes in the resting concentration of IL-6 may play a role in altered perception of effort in this context.
Somatostatin analog challenge test in the pre-surgical management of ACTH-secreting pheochromocytoma
Authors: Rossini Alessandro , Perticone Francesca , Frosio Laura , Schiavo Lena Marco , Lanzi Roberto 
Published: November 2019

Summary
ACTH-secreting pheochromocytoma is a very rare cause of Cushing’s syndrome, with a high morbidity and mortality risk due to both cortisol and catecholamines excess. We report the case of a 45-year-old female patient with a 3 cm, high-density, left adrenal mass, diagnosed as an ACTH-secreting pheochromocytoma. The biochemical sensitivity of the tumor to somatostatin analogues was tested by a 100 μg s.c. octreotide administration, which led to an ACTH and cortisol reduction of 50 and 25% respectively. In addition to alpha and beta blockers, preoperative approach to laparoscopic adrenalectomy included octreotide, a somatostatin analogue, together with ketoconazole, in order to achieve an adequate pre-surgical control of cortisol release. Histopathological assessment confirmed an ACTH-secreting pheochromocytoma expressing type 2 and 5 somatostatin receptors (SSTR-2 and -5).

Learning points:

ACTH-secreting pheochromocytomas represent a rare and severe condition, characterized by high morbidity and mortality risk.

Surgical removal of the adrenal mass is the gold standard treatment, but adequate medical therapy is required preoperatively to improve the surgical outcome and to avoid major complications.

Somatostatin analogs, in addition to other medications, may represent a useful therapeutic option for the presurgical management of selected patients.

In this sense, the octreotide challenge test is a useful tool to predict favorable therapeutic response to the treatment.
Distortions introduced by normalisation of values of criteria in multiple criteria methods of evaluation
Authors: Podviezko Askoldas 
Published: November 2019

Quantitative multiple criteria decision aid (MCDA) methods of evaluation gain increasing popularity among researchers. The idea of the methods is to comprise values ofcriteria characterising each object into a single non-dimensional cumulative criterion, which reflects attractiveness or position of the object in view of an objective chosen. Normalisation of weights is a compulsory procedure whenever criteria of different dimensions are present. There several methods of normalisation available. Nevertheless, each method may introduce distortions into transformed data. The paper is devoted to exploration of problems related to such distortions and reveals particular cases.
Neurophysiological effects of various music genres on electroencephalographic (EEG) cerebral cortex activity
Authors: Rodriguez Abraham Hafiz , Zallek Sarah Nath , Xu Michael , Aldag Jean , Russell-Chapin Lori , Mattei Tobias A. , Litofsky N. Scott 
Published: November 2019

Abstract

Background
Music has been associated with therapeutic properties for thousands of years across a vast number of diverse regions and cultures. This study expands upon our current understanding of music’s influence on human neurophysiology by investigating the effects of various music genres on cerebral cortex activity using electroencephalography (EEG).

Methods
A randomized, controlled study design was used. EEG data were recorded from 23 healthy adults, ages 19–28, while listening to a music sequence consisting of five randomized songs and two controls. The five studied music genres include: Classical, Tribal Downtempo, Psychedelic Trance (Psytrance), Goa Trance, and Subject Choice.

Results
Controls were associated with lower percentages of beta frequencies and higher percentages of alpha frequencies than the music genres. Psytrance was associated with higher percentages of theta and delta frequencies than the other music genres and controls. The lowest percentages of beta frequencies and highest percentages of alpha frequencies occurred in the occipital and parietal regions. The highest percentages of theta and delta frequencies occurred in the frontal and temporal regions. Subjects with prior music training exhibited increased percentages of delta frequencies in the frontal region. Subject gender and music preference did not have a significant influence on frequency band percentages.

Conclusions
Findings from this study support those of previous music therapy studies and provide novel insights regarding music’s influence on human neurophysiology. These findings also support the hypothesis that music may promote changes in cerebral cortex activity that have similarities to non-rapid eye movement (NREM) sleep, while the listener remains awake.
AKUMULASI LOGAM BERAT Pb, Cd, Ni DAN Zn PADA DAGING IKAN DI TELUK KAO, HALMAHERA
Authors: Edward Edward 
Published: November 2019

Ikan merupakan sumber protein, mineral, vitamin dan asam lemak omega-3-tidak jenuh (poly unsaturated), yang dianggap bermanfaat bagi kesehatan. Tujuan penelitian in adalah untuk mengetahui tingkat akumulasi logam berat timbal (Pb), cadmium (Cd), seng (Zn) dan nikel (Ni) pada beberapa jenis ikan yang berbeda di Teluk Kao, Halmahera. Penelitian ini dilakuan pada bulan November 2015. Contoh ikan yang dianalisis adalah ikan suo (Sphyraena jello), tatameri (Gazza minuta), gaca (Lutjanus argentimaculatus), totodi (Synodus foetens) bubara (Caranx sp), ngafi (Stolephorus indicus) dan biji nangka (Upeneus vittatus). Kadar Pb, Cd, Zn dan Ni ditentukan dengan alat Spektrofotometer Serapan Atom (AAS). Hasilnya menunjukkan kadar Pb, Cd, Zn dan Ni masih sesuai dengan nilai ambang batas aman yang ditetapkan oleh Standard Nasional Indonesia (SNI) 2009. Untuk mengoptimalkan perlindungan terhadap kesehatan manusia, perlu dilakukan pemantauan kadar Pb, Cd, Zn dan Ni dalam daging ikan yang hidup di Teluk Kao, mengingat Teluk Kao merupakan satu-satunya perairan yang menerima masukan limbah yang berasal dari kegiatan masyarakat dan penambangan emas. Strategi manajemen risiko harus fokus pada pengurangan paparan potensial yang berasal dari konsumsi ikan.
Beden Eğitimi Öğretmeni Adaylarının Serbest Zaman Sıkılma Algısı, Yaşam Doyumu ve Sosyal Bağlılık Düzeylerinin İncelenmesi
Authors: KARA Feyza Meryem , GÜRBÜZ Bülent , KÜÇÜK KILIÇ Sonnur , ÖNCÜ Erman 
Published: November 2019

Bu araştırmanın amacı; beden eğitimi öğretmeni
adaylarının serbest zaman sıkılma algısı, yaşam doyumu ve sosyal bağlılık
düzeylerini bazı değişkenlere göre incelemek ve aralarındaki ilişkiyi
belirlemektir. Araştırmada veri toplama aracı olarak, “Serbest Zamanlarda
Sıkılma Algısı Ölçeği”, “Yaşam Doyumu Ölçeği ve “Sosyal Bağlılık Ölçeği" kullanılmıştır.
Katılımcıların serbest zamanlarında sıkılma ve doyumsuzluk algıları, yaşam
doyumları ve sosyal bağlılıkları cinsiyet değişkenine göre anlamlı bir şekilde
farklılaşmamaktadır. Öğretmen adaylarının serbest zamanlarında sıkılma ve
doyumsuzluk algıları ile yaşam doyumları sınıf ve düzenli olarak fiziksel
aktiviteye katılma durumu değişkenlerine göre anlamlı bir şekilde
farklılaşmazken, sosyal bağlılıkları ise sınıf ve düzenli olarak fiziksel
aktiviteye katılma durumu değişkenlerine göre anlamlı bir şekilde
farklılaşmaktadır. Diğer yandan öğretmen adaylarının serbest zamanlarında
sıkılma ve doyumsuzluk algıları ile sosyal bağlılıkları ekonomik durum
değişkenine göre anlamlı bir şekilde farklılaşmazken yaşam doyumları ise
ekonomik durum değişkenine göre anlamlı bir şekilde farklılaşmaktadır.
Utility of cartridge based nucleic acid amplification test in the diagnosis of extra pulmonary tuberculosis
Authors: Bairwa Mahesh Chand , Banera Mahendra Kumar , Fatehpuria Chandan Mal 
Published: November 2019

Background: Tuberculosis is one of the top 10 cause of death globally. Extra-pulmonary tuberculosis is an important clinical problem. Extra-pulmonary tuberculosis range from 30%-53% in India. Diagnosis of extra-pulmonary tuberculosis is still challenging despite many investigations. World Health Organization recommends Gene-Xpert Mycobacterium Tuberculosis/Rifampicin (Cartridge Based Nucleic Acid Amplification Test-CBNAAT) over conventional tests for diagnosis of extra-pulmonary tuberculosis which permits rapid tuberculosis diagnosis through detection of the genetic sequence of DNA of mycobacterium tuberculosis and simultaneous identification of a majority of the mutations that confirm Rifampicin resistance which is highly predictive of multi-drug resistant tuberculosis.Methods: Study was carried out over a period of one year. Patients with suggestive of extra-pulmonary tuberculosis were included in study. Diagnosis of extra-pulmonary tuberculosis carried out by clinical, radiological, biochemical analysis, cytological, bacteriological confirmation. Based on mycobacterium tuberculosis result, the study population were divided into ‘Mycobacterium Tuberculosis detected’ and ‘Mycobacterium Tuberculosis not detected’ groups. Mycobacterium Tuberculosis detected group was further divided into ‘Rifampicin resistant’ and ‘Rifampicin sensitive’.Results: Total 220 patients were included. Among extra-pulmonary tuberculosis, there were 83.64% were pleural fluid. 65.91% patients where be <45 years of age. Mostly patients were from rural areas and illiterate. Diabetes Mellitus found as the most common co-morbidities. CB-NAAT was able to detect mycobacterium tuberculosis in 35% (77) extra-pulmonary samples, out of which 6 were rifampicin resistant. Out of 184 samples of pleural fluid, 53 were rifampicin sensitive and 4 were found rifampicin resistant.Conclusions: CB-NAAT has to be endorsed in every health care centres as the test gives rapid result and also detection of rifampicin resistance which is the major concern for every clinician.