bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lithium nephropathy: Unique sonographic appearance and application of new on cart tools
Authors: Kapkanova Natasha , Elliott Carla , Lucas Deneah 
Published: February 2020

AbstractRenal toxicity is a well‐known side effect of long‐term lithium use, which may lead to chronic renal failure. Ultrasonography is effective in the assessment of this unique disorder. This case report describes the ultrasound appearances of lithium nephropathy in a 65‐year‐old female on long‐term lithium use. It will also discuss the application of shear wave elastography (SWE), the use of the hepatorenal index (HRI), and MicroPure as potential aids in the diagnosis of this condition.
Setting the Stage for TALK: Strategies for Encouraging Language‐Building Conversations
Authors: Hadley Elizabeth Burke , Newman Katherine M. , Mock Jinsil 
Published: February 2020

AbstractSupporting young students’ oral language development is vital in ensuring their future success as readers. One important way that early childhood teachers can foster language development is by having extended conversations with students. The authors share research about the importance of rich teacher–student conversations and explain how less verbal students may miss out on conversational opportunities. The authors also explain how to create conditions in the classroom that are supportive of students’ engagement and talk, then give specific strategies for encouraging extended conversations.
Cover Image, Volume 10, Issue 2
Authors: Portillo‐Ledesma Stephanie , Schlick Tamar 
Published: February 2020

The cover image is based on the Advanced Review Bridging chromatin structure and function over a range of experimental spatial and temporal scales by molecular modeling by Stephanie Portillo‐Ledesma and Tamar Schlick. https://doi.org/10.1002/wcms.1434
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Data mining powered by the gene ontology
Authors: Manda Prashanti 
Published: February 2020

AbstractThe gene ontology (GO) is a widely used resource for describing molecular functions, biological processes, and cellular components of gene products. Since its inception in 2006, the GO has been used to describe millions of gene products resulting in a massive data store of over 6 million annotations. The staggering amount of data that has resulted from annotating gene products with GO terms has led the way and opened new avenues for a wide variety of large‐scale computational analyses. Specifically, a variety of data mining techniques such as association rule mining, clustering etc. have been applied successfully to a range of biological applications. This article provides a review of four data mining applications/techniques for GO data mining gene expression data, association rule mining, clustering, and text mining and highlights future directions in each of these areas.This article is categorized under:Algorithmic Development > Association RulesAlgorithmic Development > Biological Data MiningEnsemble Methods > Text Mining
Thermodynamics of inhomogeneously mass-deformed ABJM model and pressure anisotropy
Authors: Hyun Seungjoon , Ahn Byoungjoon , Kim Kyung Kiu , Kwon O-Kab , Park Sang-A 
Published: February 2020

Abstract
In this paper we study the thermodynamics of black branes with a modulated complex scalar in the context of bulk and boundary theories. The modulation induces inhomogeneity to the dual field theory, anisotropic pressure, and brane charge to the bulk geometry. The first law of thermodynamics and the Smarr relation are obtained using the off-shell ADT and the reduced action formalisms. We discuss the prescription for the mass of black branes, which relies on relevant and marginal deformations in the dual field theory. One of the cases is the gravity dual to a ABJM model with a sinusoidal mass function depending on a spatial coordinate. This is the first study of the deformed ABJM model at finite temperature including bulk thermodynamics.
Mass production of IIA and IIB dS vacua
Authors: Cribiori Niccolò , Kallosh Renata , Linde Andrei , Roupec Christoph 
Published: February 2020

Abstract
We describe several applications of the mass production procedure proposed in [1] to stabilize multiple moduli in a dS vacuum, in supergravity models inspired by string theory. The construction involves a small downshift of an initial supersymmetric Minkowski minimum to a supersymmetric AdS minimum, and a consequent small uplift to a dS minimum. Our type IIA examples include dS stabilization in a 7-moduli model with [SL(2, ℝ)]7 tree level symmetry, and its simplified version, a 3-moduli STU model. In these models, we use uplifting anti-D6 branes. In type IIB models, we present 2- and 3-moduli examples of stable dS vacua in CY three-folds, with an uplifting anti-D3 brane. These include K3 fibration models, a CICY model and a multi-hole Swiss cheese model. We also address the issue whether this procedure is limited to a very small parameter range or if large deviations from the progenitor Minkowski vacuum are possible.
Preventable Deaths in Multiple Trauma Patients: The Importance of Auditing and Continuous Quality Improvement
Authors: Zhang Gui‐Xi , Chen Ke‐Jin , Zhu Hong‐Tao , Lin Ai‐Ling , Liu Zhong‐Hui , Liu Li‐Chang , Ji Ren , Chan Fion Siu Yin , Fan Joe King Man 
Published: February 2020

AbstractBackgroundManagement errors during pre‐hospital care, triage process and resuscitation have been widely reported as the major source of preventable and potentially preventable deaths in multiple trauma patients. Common tools for defining whether it is a preventable, potentially preventable or non‐preventable death include the Advanced Trauma Life Support (ATLS®) clinical guideline, the Injury Severity Score (ISS) and the Trauma and Injury Severity Score (TRISS). Therefore, these surrogated scores were utilized in reviewing the study's trauma services.MethodsTrauma data were prospectively collected and retrospectively reviewed from January 1, 2018, to December 31, 2018. All cases of trauma death were discussed and audited by the Hospital Trauma Committee on a regular basis. Standardized form was used to document the patient's management flow and details in every case during the meeting, and the final verdict (whether death was preventable or not) was agreed and signed by every member of the team. The reasons for the death of the patients were further classified into severe injuries, inappropriate/delayed examination, inappropriate/delayed treatment, wrong decision, insufficient supervision/guidance or lack of appropriate guidance.ResultsA total of 1913 trauma patients were admitted during the study period, 82 of whom were identified as major trauma (either ISS > 15 or trauma team was activated). Among the 82 patients with major trauma, eight were trauma‐related deaths, one of which was considered a preventable death and the other 7 were considered unpreventable. The decision from the hospital's performance improvement and patient safety program indicates that for every trauma patient, basic life support principles must be followed in the course of primary investigations for bedside trauma series X‐ray (chest and pelvis) and FAST scan in the resuscitation room by a person who meets the criteria for trauma team activation recommended by ATLS®.ConclusionMechanisms to rectify errors in the management of multiple trauma patients are essential for improving the quality of trauma care. Regular auditing in the trauma service is one of the most important parts of performance improvement and patient safety program, and it should be well established by every major trauma center in Mainland China. It can enhance the trauma management processes, decision‐making skills and practical skills, thereby continuously improving quality and reducing mortality of this group of patients.
Research on cognitive and sociocognitive functions in patients with brain tumours: a bibliometric analysis and visualization of the scientific landscape
Authors: Pertz Milena , Popkirov Stoyan , Schlegel Uwe , Thoma Patrizia 
Published: February 2020

Abstract
Background
Many patients with brain tumours exhibit mild to severe (neuro)cognitive impairments at some point during the course of the disease. Social cognition, as an instance of higher-order cognitive functioning, specifically enables initiation and maintenance of appropriate social interactions. For individuals being confronted with the diagnosis of a brain tumour, impairment of social function represents an additional burden, since those patients deeply depend on support and empathy provided by family, friends and caregivers.

Methods
The present study explores the scientific landscape on (socio)cognitive functioning in brain tumour patients by conducting a comprehensive bibliometric analysis using VOSviewer. The Web of Science Core Collection database was examined to identify relevant documents published between 1945 and 2019.

Results
A total of 664 English titles on (socio)cognitive functions in patients with brain tumours was retrieved. Automated textual analysis revealed that the data available so far focus on three major topics in brain tumour patients: cognitive functions in general and in paediatric cases, as well as psychological factors and their influence on quality of life. The focus of research has gradually moved from clinical studies with cognitive functions as one of the outcome measures to investigations of interactions between cognitive functions and psychological constructs such as anxiety, depression or fatigue. Medical, neurological and neuropsychological journals, in particular neuro-oncological journals published most of the relevant articles authored by a relatively small network of well interconnected researchers in the field.

Conclusion
The bibliometric analysis highlights the necessity of more research on social cognition in brain tumour patients.
Chronic migraine long-term regular treatment with onabotulinumtoxinA: a retrospective real-life observational study up to 4 years of therapy
Authors: Santoro Antonio , Copetti Massimiliano , Miscio Anna M. , Leone Maurizio A. , Fontana Andrea 
Published: February 2020

Abstract
Introduction
OnabotulinumtoxinA (BoNT-A) was proved effective and safe in chronic migraine (CM) prevention by the Phase III Research Evaluating Migraine Prophylaxis (PREEMPT) and Phase IV Chronic migraine OnabotulinuMtoxinA Prolonged Efficacy open-Label (COMPEL) trials over 1 and 2 years of treatment, respectively. Real-life studies highlighted BoNT-A sustained benefits up to 3 years of administration. Aim of this retrospective real-life study was observing within a 4-year timeframe the progress of a consecutive series of CM patients treated with BoNT-A and evaluating whether long-term quarterly treatment (up to 16 cycles) confirms the outcomes of previous studies over shorter periods of therapy.

Methods
One hundred nine chronic migraineurs were quarterly treated with BoNT-A according to the PREEMPT paradigm. Headache days and hours, analgesics intake and latency time together with disability were analysed at baseline, thereafter bi-annually up to 48 months. Patient responsiveness (improvement in monthly headache days and hours versus baseline) was computed at each study timepoint.

Results
A significant overall decrease from baseline to the 48-month assessment (p < 0.001) was evidenced for the mean number of monthly headache days and hours, analgesics intake and latency time. Severe disability cases significantly decreased at 6 months (p < 0.001), and a progressive shift towards lower degrees of disability was observed at each subsequent timepoint. A gradual percentage increase of responsive cases was observed as treatment was repeated over time. Transitory neck pain was reported in 6 cases.

Conclusions
This study appears to reconfirm the benefits of long-lasting CM prevention with BoNT-A, thus supporting quarterly treatment with BoNT-A over several year.
Effect of various surfactants on stability and thermophysical properties of nanofluids
Authors: Wang Jin , Li Guolong , Li Tan , Zeng Min , Sundén Bengt 
Published: February 2020

AbstractThe effect of Fe3O4 nanoparticles and carbon nanotubes (CNTs) on the viscosity of a nanofluid is experimentally investigated from 278 to 313 K by changing the nanoparticle volume fraction. These nanoparticles were put into distilled water with various surfactants, i.e., Colace (docusate sodium), trisodium citrate dihydrate (TSC), polyvinyl pyrrolidone, cetyl trimethylammonium bromide, tetramethylammonium hydroxide (TMAH), acacia senegal (GA), sodium dodecyl benzene sulfonate, sodium dodecyl sulfate (SDS), and sodium laurylsulfonate (SLS). Based on the present measurements, new empirical formulas are proposed for Fe3O4–water, CNT–water and Fe3O4–CNT–water nanofluids to provide accurate predictions for the nanofluid viscosity. Based on the viscosity testing, stabilities and thermal conductivities of Fe3O4–TMAH, Fe3O4–Colace, Fe3O4–TSC, CNT–SDS, CNT–GA, Fe3O4–CNT–SLS, and Fe3O4–CNT–TSC nanofluids with a volume concentration of 0.5% are investigated in the present research. Results indicate that better stability, smaller viscosity, and higher thermal conductivity are obtained, when the surfactants TMAH, SDS, and SLS are added into the Fe3O4–water, CNT–water, and the Fe3O4–CNT–water nanofluid, respectively. The CNT–water and Fe3O4–CNT–water nanofluids exhibit a shear-thinning behavior, whereas a linear rheological behavior can be observed by water-based Colace–Fe3O4, TMAH–Fe3O4, and TSC–Fe3O4 nanofluids.
Experimental, numerical and field study investigating a heritage structure collapse after the 2015 Gorkha earthquake
Authors: Kumar Ashutosh , Hughes Paul N. , Sarhosis Vasilis , Toll David , Wilkinson Sean , Coningham Robin , Acharya Kosh Prasad , Weise Kai , Joshi Annie , Davis Christopher , Kunwar Ram Bahadur , Maskey Prem Nath 
Published: February 2020

AbstractThis paper presents an investigation of the collapse of a 325-year-old multi-tiered heritage temple during the 2015 Gorkha earthquake in Kathmandu, Nepal. The research comprises a reconnaissance survey followed by a geotechnical investigation and numerical back-analysis carried out to understand the potential causes of the collapse. The assessment of the structural configuration of the temple indicated seismic vulnerability in the design due to the presence of discontinuous columns over the height of the temple and age-weakened bonding in the masonry walls. The geotechnical investigation revealed the presence of competent soil strata at the location, assisting the survey which indicated no differential or excessive settlement in the foundation. A series of cyclic triaxial tests were conducted on samples recovered during the geotechnical investigation to determine dynamic behaviour of the soil. Further, dynamic analysis of the plinth of the temple under the recorded acceleration–time history indicated a maximum drift percentage of 1.4% and residual relative displacement of 32 mm suggesting the potential reason behind the collapse. The output of this research will support seismic rehabilitation of ancient structures within World Heritage sites across Nepal and effective action plans to safeguard them against future earthquake hazard.
Innovation in Fischer–Tropsch: Developing Fundamental Understanding to Support Commercial Opportunities
Authors: Peacock M. , Paterson J. , Reed L. , Davies S. , Carter S. , Coe A. , Clarkson J. 
Published: February 2020

AbstractIn this contribution we provide details of the BP-Johnson Matthey proprietary Fischer–Tropsch technology and the advanced CANS reactor and catalyst system. The advanced CANS catalyst carrier reactor provides superior heat transfer, reduced pressure drop and higher productivity that lead to major economic savings. Fundamental understanding of catalyst behaviour is also key to obtaining a catalyst that is stable over the lifetime of its use. Synthesis, calcination and reduction steps introduce changes in the catalyst properties prior to syngas introduction. In particular, the presence of water can affect the final catalyst performance. The activity of a good catalyst can be significantly reduced by a sub-optimal activation or start-up. Similarly, stable operation and minimising deactivation are vital for long and stable catalyst life, with years of operation without requiring regeneration. In this report we also share a fundamental study on the catalyst activation across different catalyst supports. This combines advanced in situ techniques with reactor testing to explore the role of the support on catalyst performance. The results illustrate the critical need for a logical and systematic catalyst development programme to explore these effects to optimise the whole FT process. The combination of a joint approach in development plays a key role in a long term success in a process. The fundamental catalyst understanding, optimisation and improvements in combination with the novel CANS reactor design maximise their potential and offer the potential for a world leading technology.
Osteogenesis imperfecta – Pathophysiologie und aktuelle Behandlungsstrategien
Authors: Rehberg Mirko , Etich Julia , Leßmeier Lennart , Sill Helge , Netzer Christian , Semler Oliver 
Published: February 2020

Zusammenfassung
Die Osteogenesis imperfecta (OI) ist eine angeborene Erkrankung des Knochens und Bindegewebes. Sie geht mit einer erhöhten Frakturneigung, Deformierung der Extremität, aber auch mit extraskelettalen Symptomen einher. Nach einer kurzen Darstellung von Klinik, Diagnostik und aktueller Therapie folgt ein umfassender Überblick über die genetischen und pathophysiologischen Grundlagen der Erkrankung und die daraus abgeleiteten zukünftigen therapeutischen Möglichkeiten.
Ungefähr 80 % der Patienten haben eine Mutation in den Kollagen-Genen COL1A1 und COL1A2. Bei diesen Patienten ist für das Kollektiv keine klare Genotyp-Phänotyp-Korrelation beschrieben. Stoppmutationen führen in der Regel zu einem quantitativen Kollagendefekt, wodurch weniger normales Kollagen gebildet wird und ein eher leichter Phänotyp entsteht. Missense-Mutationen führen zu strukturell verändertem Kollagen (qualitativer Defekt) und zu einem schwereren Phänotyp. Trotzdem gibt es Unterschiede und Vorhersagen über den individuellen Verlauf sind nur sehr eingeschränkt möglich. Neben Veränderungen in den Kollagen-Genen gibt es Mutationen, welche die Kollagenmodifikation und die Kollagensekretion betreffen. Eine eigene Gruppe bilden Gene, welche an der Osteoblastendifferenzierung beteiligt sind. Wie auch bei den weiteren, nicht näher zugeordneten Genen sind dies häufig übergeordnete Gene, deren Funktion in der Osteogenese nicht völlig verstanden ist.
Abgeleitet aus den pathophysiologischen Grundlagen, können vorhandene Medikamente zukünftig womöglich zielgerichtet eingesetzt werden. So ist der „Receptor-Activator-of-Nuclear-Factor-Kappa B-Ligand“ (RANKL)-Antikörper Denosumab spezifischer als Bisphosphonate und wird schon heute bei OI-Typ VI (SERPINF1) verwendet. Weitere Medikamente wie Anti-Sklerostin oder Stammzelltherapien werden unter Berücksichtigung der Pathophysiologie aktuell entwickelt.
Imaging-guided PCI for event suppression in Japanese acute coronary syndrome patients: community-based observational cohort registry
Authors:   Kumamoto Intervention Conference Study (KICS) Investigators, Yamashita Takayoshi , Sakamoto Kenji , Tabata Noriaki , Ishii Masanobu , Sato Ryota , Nagamatsu Suguru , Motozato Kota , Yamanaga Kenshi , Sueta Daisuke , Araki Satoshi , Arima Yuichiro , Yamamoto Eiichiro , Takashio Seiji , Fujisue Koichiro , Fujimoto Kazuteru , Shimomura Hideki , Tsunoda Ryusuke , Maruyama Hideki , Nakamura Natsuki , Sakaino Naritsugu , Nakamura Shinichi , Yamamoto Nobuyasu , Matsumura Toshiyuki , Kajiwara Ichiro , Tayama Shinji , Sakamoto Tomohiro , Nakao Koichi , Oshima Shuichi , Kaikita Koichi , Hokimoto Seiji , Tsujita Kenichi 
Published: February 2020

AbstractAlthough there is accumulating evidence for the usefulness of imaging-guided percutaneous coronary intervention (PCI), there are few studies for acute coronary syndrome (ACS), and the impact of the frequency of use has not been well addressed. From the Kumamoto Intervention Conference Study; a Japanese registry comprising 17 institutions, consecutive patients undergoing successful PCI from April 2008 through March 2014 were enrolled. Subjects were divided into two groups: imaging-guided PCI and angiography-guided PCI. Clinical outcome was a composite of cardiac death, non-fatal myocardial infarction, and stent thrombosis within 1 year. A total of 6025 ACS patients were enrolled: 3613 and 2412 patients with imaging- and angiography-guided PCI, respectively. Adverse cardiac events were significantly lower in the imaging-guided PCI group (long-rank P < 0.001). Even after propensity-score matching, the event rates still showed significant differences between the two groups (log-rank P = 0.004). To assess the effects of frequency of imaging usage, we divided the 17 institutions into six low-, six moderate-, and five high-frequency groups. The event rates decreased depending on the frequency, seemingly driven by stepwise event suppression in angiography-guided PCI. In Japanese ACS patients, the incidence of adverse clinical events in patients treated with imaging-guided PCI were significantly lower than that in patients with angiography-guided PCI. Better clinical result was found in the institutions using intravascular imaging more frequently. University Hospital Medical Information Network (UMIN)-CTR (http://www.umin.ac.jp/ctr/). Identifier: KICS (UMIN000015397).
Ruin probabilities in the Cramér–Lundberg model with temporarily negative capital
Authors: Aurzada Frank , Buck Micha 
Published: February 2020

AbstractWe study the asymptotics of the ruin probability in the Cramér–Lundberg model with a modified notion of ruin. The modification is as follows. If the portfolio becomes negative, the asset is not immediately declared ruined but may survive due to certain mechanisms. Under a rather general assumption on the mechanism—satisfied by most such modified models from the literature—we study the relation of the asymptotics of the modified ruin probability to the classical ruin probability. This is done under the Cramér condition as well as for subexponential integrated claim sizes.
Twenty Years of the Food Cravings Questionnaires: a Comprehensive Review
Authors: Meule Adrian 
Published: February 2020

Abstract
Purpose of Review
The Food Cravings Questionnaires (FCQs; Cepeda-Benito, Gleaves, Williams, & Erath, 2000) are among the most widely used instruments for measuring food cravings. In addition to the Food Cravings Questionnaire–Trait (FCQ–T) and the Food Cravings Questionnaire–State (FCQ–S), several modified versions have been developed as well. For their 20th anniversary, this article provides a comprehensive description of the FCQs and reviews studies on their psychometric properties and correlates.

Recent Findings
The FCQs and their modified versions have excellent internal reliability. Expectedly, the FCQ–T (and its derivatives) has higher retest-reliability than the FCQ–S as the FCQ–S is sensitive to situational changes such as food deprivation and food intake. However, while the FCQ–T is largely unaffected by such momentary states, it is also sensitive to change during weight-loss treatments and other interventions. Factor structure of the FCQ–T and FCQ–S has only partially been replicated. Construct validity of the FCQs is supported by experimental and longitudinal studies that measured food craving and food consumption in the laboratory and with ecological momentary assessment.

Summary
Numerous studies support reliability and validity of the FCQs and their modified versions, yet findings about their factor structures are inconsistent. Thus, using total scores or the short versions of the FCQs may be preferable.