bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 24 December 2018 Eruptive Intrusion at Etna Volcano as Revealed by Multidisciplinary Continuous Deformation Networks (CGPS, Borehole Strainmeters and Tiltmeters)
Authors: Aloisi M. , Bonaccorso A. , Cannavò F. , Currenti G. , Gambino S. 
Published: July 2020

AbstractWe have modeled the fast dike intrusion that started on 24 December 2018 at Mount Etna. The intrusion was accompanied by an intense seismicity swarm that also continued the following day. Since previous studies did not detail the overall chain of events in time during the magma ascent, here we propose a combined analytical and FEM modeling of all available continuous deformation data, focusing on the signals over 2 days (24–25 December) when the continuous deformation networks recorded clear variations directly related to the dike ascent. High‐rate GPS enabled obtaining an early and reliable source model. Borehole instruments (strainmeters and tiltmeters) highlighted clear variations, starting about 1 hr before those recorded by GPS, and moreover, made it possible to improve the dike ascent modeling. In particular, our continuous deformation data clearly revealed not one but two dikes and showed how they evolved in time. We inferred one dike that began propagating in the first kilometer above sea level, continued to rise with a maximum opening of 1.9 m and increased its horizontal dimension until reaching the ground surface. Soon after, continuous deformation networks revealed a new elongated intrusion in the southern flank, matching the south shifted position of the seismic swarm. This second dike, with a thicker opening of 4.9 m, started from a depth of about −3 km (below sea level) but did not reach the ground surface. This proposed multiparametric modeling of continuous deformation data has therefore enabled disentangling the complexity of the real volcanic processes.
Impact of Atmospheric and Model Physics Perturbations on a High‐Resolution Ensemble Data Assimilation System of the Red Sea
Authors: Sanikommu Sivareddy , Toye Habib , Zhan Peng , Langodan Sabique , Krokos George , Knio Omar , Hoteit Ibrahim 
Published: July 2020

AbstractThe Ensemble Adjustment Kalman Filter of the Data Assimilation Research Testbed is implemented to assimilate observations of satellite sea surface temperature, altimeter sea surface height, and in situ ocean temperature and salinity profiles into an eddy‐resolving 4 km Massachusetts Institute of Technology general circulation model of the Red Sea. We investigate the impact of three different ensemble generation strategies: (1) Iexp—uses ensemble of ocean states to initialize the model on 1 January 2011 and inflates filter error covariance by 10%; (2) IAexp—adds ensemble of atmospheric forcing to Iexp; and (3) IAPexp—adds perturbed model physics to IAexp. The assimilation experiments are run for 1 year, starting from the same initial ensemble and assimilating data every 3 days.Results demonstrate that the Iexp mainly improved the model outputs with respect to assimilation‐free Massachusetts Institute of Technology general circulation model run in the first few months, before showing signs of dynamical imbalances in the ocean estimates, particularly in the data‐sparse subsurface layers. The IAexp yielded substantial improvements throughout the assimilation period with almost no signs of imbalances, including the subsurface layers. It further well preserved the model mesoscale features resulting in an improved forecast for eddies, both in terms of intensity and location. Perturbing model physics in IAPexp slightly improved the forecast statistics and also the placement of basin‐scale eddies. Increasing hydrographic coverage further improved the results of IAPexp compared to IAexp in the subsurface layers. Switching off multiplicative inflation in IAexp and IAPexp leads to further improvements, especially in the subsurface layers.
Plasma tumour DNA as an early indicator of treatment response in metastatic castration-resistant prostate cancer
Authors: Conteduca Vincenza , Wetterskog Daniel , Scarpi Emanuela , Romanel Alessandro , Gurioli Giorgia , Jayaram Anuradha , Lolli Cristian , Tandefelt Delila Gasi , Schepisi Giuseppe , Casadei Chiara , Wingate Anna , Matteucci Federica , Paganelli Giovanni , Gonzalez-Billalabeitia Enrique , Demichelis Francesca , De Giorgi Ugo , Attard Gerhardt 
Published: July 2020

ABSTRACT
Background
Plasma tumour DNA (ptDNA) levels on treatment are associated with response in a variety of cancers. However, the role of ptDNA in prostate cancer monitoring remains largely unexplored. Here we characterised on-treatment ptDNA dynamics and evaluated its potential for early assessment of therapy efficacy for metastatic castration-resistant prostate cancer (mCRPC).

Methods
Between 2011 and 2016, 114 sequential plasma samples from 43 mCRPC abiraterone-treated patients were collected. Targeted next-generation sequencing was performed to determine ptDNA fraction. ptDNA progressive disease was defined as a rise in the fraction compared to the pre-treatment.

Results
A ptDNA rise in the first on-treatment sample (interquartile range (IQR) 2.6–3.7 months) was significantly associated with increased risk of early radiographic or any prostate-specific antigen (PSA) rise (odds ratio (OR) = 15.8, 95% confidence interval (CI) 3.5–60.2, p = 0.0002 and OR = 6.0, 95% CI 1.6–20.0, p = 0.01, respectively). We also identified exemplar cases that had a rise in PSA or pseudoprogression secondary to bone flare but no rise in ptDNA. In an exploratory analysis, initial ptDNA change was found to associate with the duration of response to prior androgen deprivation therapy (p < 0.0001) but not to prior taxanes (p = 0.32).

Conclusions
We found that ptDNA assessment for therapy monitoring in mCRPC is feasible and provides data relevant to the clinical setting. Prospective evaluation of these findings is now merited.
Refining anodic and cathodic dissolution mechanisms: combined AESEC-EIS applied to Al-Zn pure phase in alkaline solution
Authors: Han Junsoo , Vivier Vincent , Ogle Kevin 
Published: July 2020

AbstractIn this work, the use of atomic emission spectroelectrochemistry (AESEC) coupled to electrochemical impedance spectroscopy (EIS) is presented as a method of revealing dissolution mechanisms. To illustrate the method, the dissolution kinetics of Al cations from an Al-Zn pure phase (Zn-68 wt.% Al) was investigated in an alkaline solution. In the cathodic potential domain, a nearly direct formation of dissolved Al3+ was observed, while in the anodic potential domain the Al dissolution occurred by migration across a ZnO/Zn(OH)2 film. It was demonstrated that this methodology can be applied to a nonstationary system during a potentiostatic experiment for a lower Al content phase (Zn-22 wt.% Al). The nature of the charge transfer mechanisms depended on the applied potential and could be identified by comparing the direct current and alternating current faradaic yield using AESEC-EIS.
Strontium and oxygen isotopes as indicators of Longobards mobility in Italy: an investigation at Povegliano Veronese
Authors: Francisci Guendalina , Micarelli Ileana , Iacumin Paola , Castorina Francesca , Di Vincenzo Fabio , Di Matteo Martina , Giostra Caterina , Manzi Giorgio , Tafuri Mary Anne 
Published: July 2020

AbstractThe arrival of the Longobards in Northern Italy in 568 CE marked a period of renewed political stability in the Peninsula after the collapse of the Western Roman Empire. The trajectory of the spread of Longobards in Italy across the Alps and into the South is known from many literary sources. However, their mobility and residence patterns at a population level remain to be fully understood. Here we present a multi-isotopic analysis (87Sr/86Sr and 18O/16O) of 39 humans and 14 animals buried at the Longobard necropolis of Povegliano Veronese (VR, Italy; 6th—8th century CE), to address mode and tempo of the spread of this population in the Peninsula. The geographical location of Povegliano Veronese plays a key role: the site lies along the Via Postumia, which was one of the main ancient Roman roads of Northern Italy, representing an important route in post-classical Italy. The integration of isotopic data with the archaeological evidence allowed us to determine the presence of individuals from at least three different regions of origin, building a diachronic map of the dynamics of mobility of this group in northern Italy.
Quantifying greenhouse gas emissions from global aquaculture
Authors: MacLeod Michael J. , Hasan Mohammad R. , Robb David H. F. , Mamun-Ur-Rashid Mohammad 
Published: July 2020

AbstractGlobal aquaculture makes an important contribution to food security directly (by increasing food availability and accessibility) and indirectly (as a driver of economic development). In order to enable sustainable expansion of aquaculture, we need to understand aquaculture’s contribution to global greenhouse gas (GHG) emissions and how it can be mitigated. This study quantifies the global GHG emissions from aquaculture (excluding the farming of aquatic plants), with a focus on using modern, commercial feed formulations for the main species groups and geographic regions. Here we show that global aquaculture accounted for approximately 0.49% of anthropogenic GHG emissions in 2017, which is similar in magnitude to the emissions from sheep production. The modest emissions reflect the low emissions intensity of aquaculture, compared to terrestrial livestock (in particular cattle, sheep and goats), which is due largely to the absence of enteric CH4 in aquaculture, combined with the high fertility and low feed conversion ratios of finfish and shellfish.
Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era
Authors: Song Ga-Young , Yoon Sang Eun , Kim Seok Jin , Kim Jin Seok , Koh Youngil , Moon Joon-Ho , Oh Sung Yong , Lee Ho Sup , Shin Ho-Jin , Do Young Rok , Lee Won Sik , Kim Dae sik , Park Yong , Yhim Ho-Young , Yang Deok-Hwan 
Published: July 2020

AbstractThere are still controversies about the use of interim positron emission tomography/computed tomography (PET/CT) in indolent non-Hodgkin lymphoma due to the variable fluorodeoxyglucose (FDG) avidity. Therefore, this study aimed to evaluate the roles of interim PET/CT in marginal zone lymphoma (MZL), a representative indolent lymphoma. We analyzed the data of 146 MZL patients. All were treated with rituximab-containing immunochemotherapy. Interim PET/CT scan was performed after 2–3 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (ΔSUVmax). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Particularly, there was a significant difference in PFS between patients with interim score 1–2 and those with score 3. However, ΔSUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. In the multivariate analysis, failure to achievement of grade 1–2 in interim PET/CT was significantly associated with inferior PFS (HR, 2.154; 95% CI 1.071–4.332; p = 0.031). The interim PET/CT response based on the 5-PS is useful for predicting PFS of patients with MZL in the post-rituximab era.
Colonization kinetics and implantation follow-up of the sewage microbiome in an urban wastewater treatment plant
Authors: Morin Loïc , Goubet Anne , Madigou Céline , Pernelle Jean-Jacques , Palmier Karima , Labadie Karine , Lemainque Arnaud , Michot Ophélie , Astoul Lucie , Barbier Paul , Almayrac Jean-Luc , Sghir Abdelghani 
Published: July 2020

AbstractThe Seine-Morée wastewater treatment plant (SM_WWTP), with a capacity of 100,000 population-equivalents, was fed with raw domestic wastewater during all of its start-up phase. Its microbiome resulted from the spontaneous evolution of wastewater-borne microorganisms. This rare opportunity allowed us to analyze the sequential microbiota colonization and implantation follow up during the start-up phase of this WWTP by means of regular sampling carried out over 8 months until the establishment of a stable and functional ecosystem. During the study, biological nitrification–denitrification and dephosphatation occurred 68 days after the start-up of the WWTP, followed by flocs decantation 91 days later. High throughput sequencing of 18S and 16S rRNA genes was performed using Illumina's MiSeq and PGM Ion Torrent platforms respectively, generating 584,647 16S and 521,031 18S high-quality sequence rDNA reads. Analyses of 16S and 18S rDNA datasets show three colonization phases occurring concomitantly with nitrification, dephosphatation and floc development processes. Thus, we could define three microbiota profiles that sequentially colonized the SM_WWTP: the early colonizers, the late colonizers and the continuous spectrum population. Shannon and inverse Simpson diversity indices indicate that the highest microbiota diversity was reached at days 133 and 82 for prokaryotes and eukaryotes respectively; after that, the structure and complexity of the wastewater microbiome reached its functional stability. This study demonstrates that physicochemical parameters and microbial metabolic interactions are the main forces shaping microbial community structure, gradually building up and maintaining a functionally stable microbial ecosystem.
Chemical weathering and CO2 consumption rates of rocks in the Bishuiyan subterranean basin of Guangxi, China
Authors: Jiang Pingping , Yu Guo , Zhang Qiang , Zou Yane , Tang Qingjia , Kang Zhiqiang , Sytharith Pen , Xiao He 
Published: July 2020

AbstractTo investigate the influence of chemical weathering on CO2 consumption, an analysis was performed of water chemistry by applying water chemistry equilibria methods in the Bishuiyan subterranean basin, SW China. The average value of total ion concentrations (TZ+) was 1,854.97 μEq/L, which was significantly higher than the global average value (TZ+ = 1,250 μEq/L). Ca2+ and HCO3− were the main ionic constituents in the waters. SO42− and NO3− concentrations were relatively higher than other anion concentrations, and Cl− concentrations were consistently the lowest. Dissolved load balance models result showed that carbonate weathering, silicate weathering, and atmospheric input were the primary ionic contributors, wherein the effects of carbonate weathering > silicate weathering > atmospheric input for the whole catchment, with the exception of Taiping, where silicate weathering was prominent over carbonate weathering. In addition, these analyses indicated that the erosion via rock weathering was also affected by atmospherically derived CO2 and allogenic acids. The estimated yield by quantitative calculation for the carbonate weathering rate was 59.7 t/(km2 year), which was 4.40 times higher than that of silicate weathering rate. Further, the carbonate and silicate weathering components of the carbon sink accounted for 71.2% and 28.8%, respectively, of the total basin rock weathering carbon sink.
Rapid detection of microbiota cell type diversity using machine-learned classification of flow cytometry data
Authors: Özel Duygan Birge D. , Hadadi Noushin , Babu Ambrin Farizah , Seyfried Markus , van der Meer Jan R. 
Published: July 2020

AbstractThe study of complex microbial communities typically entails high-throughput sequencing and downstream bioinformatics analyses. Here we expand and accelerate microbiota analysis by enabling cell type diversity quantification from multidimensional flow cytometry data using a supervised machine learning algorithm of standard cell type recognition (CellCognize). As a proof-of-concept, we trained neural networks with 32 microbial cell and bead standards. The resulting classifiers were extensively validated in silico on known microbiota, showing on average 80% prediction accuracy. Furthermore, the classifiers could detect shifts in microbial communities of unknown composition upon chemical amendment, comparable to results from 16S-rRNA-amplicon analysis. CellCognize was also able to quantify population growth and estimate total community biomass productivity, providing estimates similar to those from 14C-substrate incorporation. CellCognize complements current sequencing-based methods by enabling rapid routine cell diversity analysis. The pipeline is suitable to optimize cell recognition for recurring microbiota types, such as in human health or engineered systems.
Inhibition of Na+/K+ ATPase blocks Zika virus infection in mice
Authors: Guo Jiao , Jia Xiaoying , Liu Yang , Wang Shaobo , Cao Junyuan , Zhang Bo , Xiao Gengfu , Wang Wei 
Published: July 2020

AbstractZika virus (ZIKV) is an infectious disease that has become an important concern worldwide, it associates with neurological disorders and congenital malformations in adults, also leading to fetal intrauterine growth restriction and microcephaly during pregnancy. However, there are currently no approved vaccines or specific antiviral drugs for preventing or treating ZIKV infection. Here, we show that two FDA-approved Na+/K+-ATPase inhibitors, ouabain and digoxin, can block ZIKV infection at the replication stage by targeting Na+/K+-ATPase. Furthermore, ouabain reduced the viral burden of ZIKV in adult mice, penetrated the placental barrier to enter fetal tissues, and protected fetal mice from ZIKV infection-induced microcephaly in a pregnant mouse model. Thus, ouabain has therapeutic potential for ZIKV.
One-pot synthesis of a hydrogen peroxide-selective fluorogenic probe and its application in Parkinson's diseasein vitroandvivomodels
Authors: Lu Yao , Peng Bo , Qiu Xinghan , Li Xin , Li Zheng , Zhang Duoteng , Ji Wenhui , Fang Bin , Wu Qiong , Zhang Chengwu , Li Lin , Huang Wei 
Published: July 2020

An abnormal level of hydrogen peroxide in neurons is strongly implicated in the progression of Parkinson’s disease. A one-pot multicomponent reaction has been utilized to synthesise phosphate ester-based probe for imaging of H2O2 in living cells andDrosophilaPD model.
Antikoagulation bei Vorhofflimmern
Authors: Hohnloser Stefan 
Published: July 2020

AbstractAnticoagulation with oral antagonists without vitamin K (NOACs) is the preferred therapy for stroke prevention in atrial fibrillation. Vitamin K antagonists (VKA) should only be prescribed if there are contraindications to NOAC (e. g. mechanical heart valves, rheumatic mitral stenosis). The guideline recommendations are based on dedicated NOAC development programs with large randomized clinical phase III studies. Data from observational studies on the efficacy and safety of NOACs compared to VKA are in general complementary to data stemming from the phase III studies. Due to their pharmacokinetic and dynamic properties, NOACs are much easier to handle than VKA. Amongst other advantages, this implies that in case of short interruptions in anticoagulation therapy (e. g. for surgical procedures), bridging therapy with heparin is no longer required. This will reduce bleeding complications dramatically.
Die Gichtarthritis: Pathogenese, Diagnostik und Behandlung
Authors: Keyßer Gernot 
Published: July 2020

AbstractThe initial presentation of gouty arthritis can be a dramatic event. Chronic gout may lead to the destruction of joints, invalidity and increased mortality. The incidence of this disorder is high, despite effective therapeutic measures. The treatment of refractory cases may be a challenge to the general practitioner and the specialist alike. The article presented here summarizes the current state of diagnostics and treatment of acute and chronic gout.
Chemical Constituents from Physalis Calyx seu Fructus and Their Inhibitory Effects against Oxidative Stress and Inflammatory Response
Authors: Hu Hui-Xin , Xu Lin-Tao , Gao Hui , Lv Hui , Huang Min , Fang Kai-Li , Wang Shu-Qi , Zhao Bao-Bing , Ren Dong-Mei , Wang Xiao-Ning , Lou Hong-Xiang , Shen Tao 
Published: July 2020

AbstractPhysalis Calyx seu Fructus, a traditional Chinese medicine consisting of the calyxes and fruits of Physalis alkekengi var. franchetii, has been used as therapy for inflammation-related respiratory diseases such as excessive phlegm, cough, sore throat, and pharyngitis for a long history in China. The aim of the present study was to investigate the chemical constituents of Physalis Calyx seu Fructus and identify the bioactive constituents responsible for its traditional application as therapy for inflammation-related diseases. In the present study, one new phenylpropanoid (1), two new steroids (17 and 18), together with 55 known constituents have been purified from the EtOH extract of Physalis Calyx seu Fructus. Among them, seven and twelve known constituents were isolated for the first time from Physalis Calyx seu Fructus and the genus Physalis, respectively. Fourteen constituents, including steroids [physalins (5 – 9, 12 – 14, and 15) and ergostane (21)], a sesquiterpenoid (35), alkaloids (36 and 37), and a flavonoid (44), showed inhibitory effects against oxidative stress. Ten constituents, including steroids (5, 6, 8, 13, and 15), sesquiterpenoids (34 and 35), alkaloids (37 and 41), and a flavonoid (43), were found be potential anti-inflammatory constituents of this medicinal plant. The inhibition of oxidative stress and inflammatory response may be related to the regulation of Nrf2 and nuclear factor-κB pathways. The ethnomedical use of Physalis Calyx seu Fructus as a treatment for respiratory diseases might be attributed to the combined inhibitory effects of steroids, alkaloids, sesquiterpenoids, and flavonoids against oxidative stress and inflammatory response.
Platelet Inhibition with Ticagrelor versus Clopidogrel in Diabetic Patients after Percutaneous Coronary Intervention for Chronic Coronary Syndromes
Authors: Liu Zhenyu , Tian Ran , Wang Yang , Chen Qian , Li Jingyi , Xu Lihong , Zhang Shuyang 
Published: July 2020

Abstract
Background Clopidogrel is currently the only P2Y12 inhibitor with class I recommendation in patients after percutaneous coronary intervention (PCI) for chronic coronary syndromes (CCS). Diabetic patients have reduced therapeutic response to clopidogrel.
Purpose This study assessed the antiplatelet effect of ticagrelor versus clopidogrel in diabetic patients after recent PCI for CCS.
Methods Eligible patients were randomly assigned to receive ticagrelor 90 mg twice daily or clopidogrel 75 mg once daily, in addition to aspirin 100 mg once daily for 15 days. P2Y12 reaction unit (PRU) and percent inhibition were measured by VerifyNow P2Y12 assay. High on-treatment platelet reactivity (HOPR) was defined as PRU > 208. Bleeding was assessed by the Platelet Inhibition and Patient Outcomes criteria. Cardiac ischemic events were evaluated as adverse events.
Results The baseline characteristics of the patients (n = 39) were well balanced between the two groups. Both before and 2 to 4 hours after the final study dose on day 15, PRU was lower (41.3 ± 35.8 vs. 192.6 ± 49.5, p < 0.001; 36.6 ± 25.8 vs. 187.6 ± 70.9, p < 0.001), percent inhibition was higher (83.0% [70.5%, 96.0%] vs. 16.0% [0%, 25.0%], p < 0.001; 85.0% [76.0%, 96.5%] vs. 25.0% [0%, 39.0%], p < 0.001), and HOPR occurred less frequently (0% [0/20] vs. 26.3% [5/19], p = 0.020; 0% [0/20] vs. 31.6% [6/19], p = 0.008) in the ticagrelor group (n = 20) compared with the clopidogrel group (n = 19). No major or minor bleeding, or serious adverse events occurred in both groups.
Conclusion Ticagrelor achieved greater peak and trough platelet inhibition than did clopidogrel in diabetic patients after recent PCI for CCS, which suggests the potential use of ticagrelor in this clinical setting.