bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin Prevents Brain Damage and Cognitive Dysfunction During Ischemic-reperfusion Through the Regulation of miR-7-5p
Authors: Xu Hui , Nie Beibei , Liu Lamei , Zhang Chunhui , Zhang Zhenxiang , Xu Mengya , Mei Yongxia 
Published: October 2019

Objective:This study was to investigate the potential protective effects of curcumin in cerebral ischemia-reperfusion (CIR) and its regulation of miR-7.Methods:Rats were occluded by middle cerebral artery occlusion (MCAO) for 1.5 h and reperfused for 2 h to establish a local CIR model. After 24 hours of model establishment, MCAO rats were given curcumin for 3 days by intragastric administration. PC12 cells were cultured for 6 h in oxygen-glucose deprivation medium and then reoxygenated for 24 h to establish an oxygenglucose deprivation/reoxygenation (OGD/R) model. The OGD/R model cells were treated with curcumin for 48 h.Results:Curcumin inhibited the decrease of miR-7-5p expression and an increase of RelA p65 expression induced by CIR and ODG/R. RelA p65 was a target of miR-7-5p. MiR-7-5p antagonists were able to counteract the effect of curcumin on the expression of RelA p65 in ischemic brain tissue of MCAO rats and OGD/R model cells. Curcumin improved OGD/R-induced inhibition of cell activity, necrosis and apoptosis. Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells. Curcumin may inhibit OGD/R-induced cell damage by regulating miR-7-5p. Curcumin improved cerebral infarction, nerve damage and cognitive dysfunction in rats with CIR, which may be related to the regulation of miR-7-5p/RelA p65 axis.Conclusion:Curcumin exerts cerebral protection by attenuating cell necrosis and apoptosis, inflammatory response and oxidative stress following CIR, which may be related to its regulation of the miR-7/RELA p65 axis.
Mycophenolate Mofetil-induced Oral Ulcerations in a Kidney Transplant Recipient
Authors: Gaied Hanène , Bacha Mohamed Mongi , Mesbahi Tasnim , Ounissi Mondher , Aoudia Raja , Jerbi Mouna , Jones Mariem , Ksantini Mariem , Rammeh Soumaya , Hedri Hafedh , Goucha Rim , Abdallah Taieb Ben 
Published: October 2019

Introduction:
Mycophenolate Mofetil (MMF) is an immunosuppressive drug usually
used in kidney transplants to prevent rejection. It has various adverse effects such as leucopenia,
anemia, diarrhea but Mouth ulcers are rarely reported.

Methods:
We present a case report of MMF-induced mouth ulcers in an African patient.

Case Report:
A 41-year-old African-male patient has painful oral ulcers which developed 5 months
after kidney transplantation. The immunosuppressive maintenance regimen comprised Steroids,
Tacrolimus and MMF.

Results:
These ulcers were firstly related to a fungic or viral infection so the patient was prescribed
Fluconazole and Aciclovir without any improvement. Then, Tacrolimus blood level was checked
and it was in a therapeutic range. Finally, we decide to stop MMF and the ulcers healed quickly.

Discussion:
Oral ulcers are frequently seen complications in immunosuppressant patient but are
rarely described with MMF. These ulcers can become large and very painful and degrade patient's
life quality. So when infections causes are excluded, we have to keep in mind that these ulcers can
be a drug adverse effect.
Morin Inhibits Ovarian Cancer Growth through the Inhibition of NF-κB Signaling Pathway
Authors: Xu Meimei , Zhang Yan 
Published: October 2019

Background &Objective:
Ovarian cancer has the highest mortality in gynecological tumors without
effective therapeutic drugs as a result of drug-resistance for long-term utilization. Morin has been reported to
possess powerful anti-tumor effects in several cancers. The present study aims to investigate whether Morin
could influence ovarian cancer growth and underlying mechanisms.

Methods:
Morin was administered to cultured cells in vitro and formed tumors in vivo. MTT and colony formation
assays were performed to explore the effects of Morin on the proliferation and colony formation of
OVCAR3 and SKOV3 ovarian cancer cells. Western blot, RT-qPCR, immunofluorescence as well as ELISA
were used to detect protein and mRNA expression of target factors. Tumor formation was performed to investigate
tumorigenesis ability of drug-treated cells.

Results:
The proliferation and colony size of OVCAR3 and SKOV3 were significantly decreased after Morin
administration. The expression of NF-κB and inflammatory cytokine IL6/8 induced by TNF-α can be inhibited
by Morin. Furthermore, Morin inhibited the volume of ovarian cancer tumors in nude mice.

Conclusion:
Morin effectively alleviates ovarian cancer growth, inhibits the inflammatory response, and reduces
tumor size via modulation of the NF-κB pathway.
3,4-Dihydropyrimidin-2(1H)-One Analogues: Microwave irradiated Synthesis with Antimicrobial and Antituberculosis Study
Authors: Patel Navin , Pathan Sabir , Soni Hetal I. 
Published: October 2019

Background:For rapid and sustainable synthesis, microwave irradiation method is serviceable. This present study deals with the preparation of oxadiazole and pyridine bearing 1,2,3,4- tetrahydro pyrimidine derivatives by microwave irradiation.Objective:The present study aims to carry out rapid synthesis of chloro-acetamides of oxadiazoles of Biginelli product and amino cyano derivative of pyridine by microwave-assisted heating. Our efforts are focused on the introduction of chemical diversity in the molecular framework in order to synthesize pharmacologically interesting compounds.Methods::Microwave irradiation was used for the synthesis of 2-((3-cyano-4-(3,4-dichloro phenyl)- 6-(4-hydroxy-3-methoxyphenyl) pyridin-2-yl) amino)-N-(5-(substituted) -(6-methyl-2-oxo -1,2,3,4- tetrahydro pyrimidin-5-yl)-1,3,4-oxadiazol-2-yl)acetamide by using Biginelli reaction. New structural analogues were confirmed by spectral studies followed by their screening for in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus Pyogenus, Escherichia coli and Pseudomonas aeruginosa bacterial strains and for antifungal activity against Candida albicans, Aspergillus niger and Aspergillus clavatus by micro-broth dilution method. In vitro antimycobacterial activity determined out against (Mycobacterium tuberculosis) H37Rv strain using Lowenstein-Jensen medium.Results:As compared to the conventional method, microwave irradiation method is advantageous for the synthesis of 1,2,3,4-tetrahydropyrimidin derivatives. Potent antimicrobial activities and antitubercular activity were found for some of the compounds.Conclusion:Microwave irradiation method provided an effective way to discover a novel class of antimicrobial and antituberculosis agents. 1,2,3,4-tetrahydropyrimidin derivatives showed improved antimicrobial and good antituberculosis activity.
Potential Benefits and Drawbacks of Virtual Clinics in General Surgery: Pilot Cross-Sectional Questionnaire Study
Authors: Rutherford Emily , Noray Roghinio , Ó hEarráin Caolán , Quinlan Kevin , Hegarty Aisling , Ekpotu Lenin , Arize Chinedum , Fabamwo Fiyinfoluwa , Alrubaiaan Abdulaziz , Bhupalan Avinash , Alshehhi Abdulla , Power Colm , Hill Arnold David Konrad 
Published: October 2019

Background
Escalating demand for specialist health care puts considerable demand on hospital services. Technology offers a means by which health care providers may increase the efficiency of health care delivery.

Objective
The aim of this study was to conduct a pilot study of the feasibility, benefits, and drawbacks of a virtual clinic (VC) in the general surgical service of a busy tertiary center.

Methods
Patient satisfaction with current care and attitudes to VC were surveyed prospectively in the general surgical outpatient department (OPD; n=223). A subset of patients who had undergone endoscopy and day surgery were recruited to follow-up in a VC and subsequently surveyed with regard to their satisfaction (20/243). Other outcomes measured included a comparison of consultation times in traditional and virtual outpatient settings and financial cost to both patients and the institution.

Results
Almost half of the patients reported barriers to prospective use of VCs. However, within the cohort who had been followed-up in the VC, satisfaction was higher than the traditional OPD (100% as compared with 187/223, 83.9%). Significant savings in both time (P=.003) and financial costs to patients and the institution were found.

Conclusions
For an appropriately selected group of patients, VCs offer a viable alternative to traditional OPD. This alternative can improve both patient satisfaction and efficiency of patient care.
Accuracy of a Chatbot (Ada) in the Diagnosis of Mental Disorders: Comparative Case Study With Lay and Expert Users
Authors: Jungmann Stefanie Maria , Klan Timo , Kuhn Sebastian , Jungmann Florian 
Published: October 2019

Background
Health apps for the screening and diagnosis of mental disorders have emerged in recent years on various levels (eg, patients, practitioners, and public health system). However, the diagnostic quality of these apps has not been (sufficiently) tested so far.

Objective
The objective of this pilot study was to investigate the diagnostic quality of a health app for a broad spectrum of mental disorders and its dependency on expert knowledge.

Methods
Two psychotherapists, two psychology students, and two laypersons each read 20 case vignettes with a broad spectrum of mental disorders. They used a health app (Ada—Your Health Guide) to get a diagnosis by entering the symptoms. Interrater reliabilities were computed between the diagnoses of the case vignettes and the results of the app for each user group.

Results
Overall, there was a moderate diagnostic agreement (kappa=0.64) between the results of the app and the case vignettes for mental disorders in adulthood and a low diagnostic agreement (kappa=0.40) for mental disorders in childhood and adolescence. When psychotherapists applied the app, there was a good diagnostic agreement (kappa=0.78) regarding mental disorders in adulthood. The diagnostic agreement was moderate (kappa=0.55/0.60) for students and laypersons. For mental disorders in childhood and adolescence, a moderate diagnostic quality was found when psychotherapists (kappa=0.53) and students (kappa=0.41) used the app, whereas the quality was low for laypersons (kappa=0.29). On average, the app required 34 questions to be answered and 7 min to complete.

Conclusions
The health app investigated here can represent an efficient diagnostic screening or help function for mental disorders in adulthood and has the potential to support especially diagnosticians in their work in various ways. The results of this pilot study provide a first indication that the diagnostic accuracy is user dependent and improvements in the app are needed especially for mental disorders in childhood and adolescence.
Examining the Ethical Implications of Health Care Technology Described in US and Swedish PhD Dissertations: Protocol for a Scoping Review
Authors: Nygren Jens M , de Ruiter Hans-Peter 
Published: October 2019

BackgroundThe development of new biomedical technologies is accelerating at an unprecedented speed. These new technologies will undoubtedly bring solutions to long-standing problems and health conditions. However, they will likely also have unintended effects or ethical implications accompanying them. It may be presumed that the research behind new technologies has been evaluated from an ethical perspective; however, the evidence that this has been done is scant.ObjectiveThis study aims to understand whether and in what manner PhD dissertations focused on health technologies describe actual or possible ethical issues resulting from their research.MethodsThe purpose of scoping reviews is to map a topic in the literature comprehensively and systematically to identify gaps in the literature or identify key evidence. The search strategy for this protocol will include electronic databases (eg, ProQuest, PubMed, Diva, SwePub, and LIBRIS). Searches will be limited to PhD dissertations published in the United States and Sweden in the last 10 years. The study will be mapped in 5 stages: (1) identifying the research question, (2) identifying relevant studies, (3) study selection, (4) retrieving and charting the data, and (5) collating, summarizing, and reporting the results.ResultsThe findings of this study will indicate if and how researchers, PhD students, and their supervisors are considering ethics in their studies, including both research ethics and the ethical implications of their work. The findings can guide researchers in determining gaps and shortcomings in current doctoral education and offer a foundation to adjusting doctoral research education.ConclusionsIn a society where technology and research are advancing at speeds unknown to us before, we need to find new and more efficient ways to consider ethical issues and address them in a timely manner. This study will offer an understanding of how ethics is currently being integrated into US and Swedish PhD dissertations and inform the future direction of ethics education at a doctoral level.International Registered Report Identifier (IRRID)PRR1-10.2196/14157
Praktik Konservasi Dasar bagi Staf Museum Nonkonservator di Daerah Istimewa Yogyakarta
Authors: Mahirta Mahirta , Pramujo Asies Sigit 
Published: October 2019

Conservation knowledge and practices are very important to be applied in museums to ensure that the collection always in good condition. The problem is that not every museum in Yogyakarta has professional conservator in their management. This condition lead to the collection lack of proper attention from the conservation perspective. Based on the condition found in Yogyakarta, than it is considered necessary to give a basic training in the conservation practices that can be carried out by each museum staff that are non- conservator. Hopefully the knowledge gained can be usefull and can be applied to conserve the collection in each museum participants.-------------------------------------------------------------------Pengetahuan dan praktik konservasi sangat penting untuk diterapkan di museum oleh para konservator untuk menjamin koleksi museum selalu dalam kondisi baik. Masalahnya adalah tidak setiap museum di Yogyakarta memiliki tenaga konservator profesional dalam sistem manajemennya. Kondisi ini dapat berdampak pada kurangnya perhatian dari sudut pandang konservasi pada koleksi-koleksi yang ada. Berdasarkan pada kondisi yang ditemukan di museum-museum Yogyakarta, dipandang perlu untuk memberikan pelatihan dasar di bidang praktik-praktik konservasi yang dapat dilakukan oleh setiap museum staf nonkonservator. Harapannya, pengetahuan yang diperoleh dapat berguna dan dapat diaplikasikan untuk mengonservasi koleksi yang ada di setiap museum para peserta pelatihan.
Workshop Penulisan Karya Sastra untuk Musyawarah Guru Mata Pelajaran (MGMP) Bahasa Indonesia Se-Kabupaten Cirebon
Authors: Indrastuti Novi Siti Kussuji , Anwar Asef Saeful 
Published: October 2019

Musyawarah Guru Mata Pelajaran (MGMP) in Cirebon District can be said to be lagging behind in following the development of the discourse of literature and writing because it is the outermost region of West Java Province. In connection with this, the Community Service activities carried out by the Indonesian Language and Literature Study Program, UGM Faculty of Cultural Sciences aim to convey the process of writing literary works that are easy and effective, revealing ways of developing stories in literary writing, and encouraging the publication of literary works written by participants in print and online. The methods used in the implementation of this activity are exemplary presentation methods, discussion and question and answer, persuasion, and practice and participation. In this writing workshop, three main points were presented which were the core material of this activity, namely the process of writing literary works, the technique of developing stories, and the use of media publications.-------------------------------------------------------------------Musyawarah Guru Mata Pelajaran (MGMP) Bahasa Indonesia SMP se-Kabupaten Cirebon dapat dikatakan tertinggal dalam mengikuti perkembangan wacana karya sastra dan penulisannya karena merupakan wilayah terluar Jawa Barat. Sehubungan dengan hal tersebut, kegiatan Pengabdian kepada Masyarakat yang dilakukan oleh Prodi Bahasa dan Sastra Indonesia, Fakultas Ilmu Budaya UGM bertujuan menyampaikan proses penulisan karya sastra yang mudah dan efektif, mengungkapkan cara pengembangan cerita dalam penulisan karya sastra, dan mendorong terpublikasikannya karya sastra yang ditulis para peserta dalam bentuk cetak ataupun daring. Metode yang digunakan dalam pelaksanaan kegiatan ini adalah metode presentasi ekstemporan, diskusi dan tanya-jawab, persuasi, serta praktik dan partisipatif. Dalam workshop penulisan ini disampaikan tiga hal pokok yang menjadi inti materi kegiatan ini, yakni proses penulisan karya sastra, teknik pengembangan cerita, dan pemanfaatan media publikasi.
Modus Operandi Político de evangélicos e católicos: consolidações e inflexões
Authors: Carranza Brenda 
Published: October 2019

Sustento a hipótese de que nas últimas décadas consolidou-se o modus
operandi político dos evangélicos que impulsiona uma inflexão no histórico estilo de operar na esfera política da Igreja Católica. Se tal guinada no catolicismo não é um efeito mecânico de espelhamento, no mínimo constitui-se numa forte referência para o ativismo político católico e as militâncias de seus religiosos políticos nas casas legislativas do Brasil. A argumentação apóia-se na análise dos dados trazidos por Erico Tavares de Carvalho Junior e Ari Pedro Oro, no texto “Eleições municipais 2016: religião e política nas capitais brasileiras”, na literatura especializada e em pesquisa empírica realizada junto às lideranças católicas carismáticas.
EVANGÉLICOS, MÍDIAS E PERIFERIAS URBANAS: QUESTÕES PARA UM DIÁLOGO SOBRE RELIGIÃO, CIDADE, NAÇÃO E SOCIEDADE CIVIL NO BRASIL CONTEMPORÂNEO
Authors: Machado Carly 
Published: October 2019

O objetivo deste artigo é dialogar com as questões analíticas provocadas
por Paula Montero em seu artigo “Religião cívica, religião civil e religião pública: continuidades e descontinuidades”, destacando algumas reflexões específicas ao tomar como ponto de partida meus interesses acerca das relações entre o “meio evangélico” e o “problema da política” hoje no Brasil, com ênfase em questões articuladas ao tema da mídia, das questões urbanas, e das periferias. Em cada um dos tópicos abordados, procurarei explicitar o diálogo com o texto de Montero, e
aspectos pontuais da relação entre religião e política que a autora destaca em sua análise das expressões “religião cívica”, “religião civil”, e “religião pública”. Somando-me a outros autores neste campo de estudos, pretendi neste texto discutir não apenas o conteúdo, mas a forma da ação religiosa e política evangélica, pois esta compreensão é elemento crucial para uma análise densa do Brasil contemporâneo e suas transformações, dentre elas a forte ameaça evangélica à hegemonia Católica na produção dos termos do debate sobre política, nação, sociedade civil e cultura
no Brasil. Destaco dentre os temas discutidos, a centralidade de um olhar sobre a relação entre religião e mídia (esta última entendida como mediação, política, negócio, campo de sentidos, disputas, afetos e modo de ocupar vidas e territórios) como via analítica potente a fim de construirmos um quadro de referências consistente para um debate sobre o tempo e o espaço da política que vivemos no Brasil e no mundo na contemporaneidade.
MARXISMO, MÍSTICA E O MST: QUAL É O SEGREDO DO MST NA LUTA PELA REFORMA AGRÁRIA NO BRASIL?
Authors: McGeoch Graham Gerald 
Published: October 2019

Este texto propõe apresentar a mística do Movimento dos Trabalhadores
Rurais Sem Terra (MST) no Brasil e discutir à luz da teologia da libertação e em diálogo com as ciências sociais, passos metodológicos para melhor compreender a importância ao MST na sua luta, resistência e projeto político. No primeiro momento do texto, são considerados estudos elaborados por cientistas sociais sobre o uso da mística no MST. Após, a discussão é analisada à luz da metodologia da Teologia da Libertação. Finalmente, propõe um diálogo entre Ciências Sociais e Teologia da Libertação para melhor compreender a mística do MST e para apontar um caminho pelo qual outros movimentos sociais e militantes políticos possam incorporar a mística em suas lutas por justiça sem, simplesmente, se tornarem uma cópia do MST.
Clinical Performance of a Glass Hybrid Restorative in Extended Size Class II Cavities
Authors: Gurgan S , Kutuk ZB , Ozturk C , Soleimani R , Cakir FY 
Published: October 2019

SUMMARY

Objective:
To evaluate the clinical performance of a glass hybrid restorative compared with a resin composite in the restoration of large and deep Class II cavities after 24 months.

Methods and Materials:
A total of 108 extended size, with the width of the proximal box not interfering with the peak of the cusps and the proximal box in occlusion, Class II lesions in 37 patients were either restored with a glass hybrid restorative or with a micro-hybrid composite resin in combination with selective etching by two experienced operators according to the manufacturer's instructions. Two independent examiners evaluated the restorations at baseline and at the six-, 12-, 18-, and 24-month recalls according to the modified US Public Health Service criteria. Negative replicas at each recall were observed under scanning electron microscopy (SEM) to examine surface characteristics. Data were analyzed statistically.

Results:
After 24 months, 90 restorations were evaluated in 32 patients (recall rate: 86.5%). Four glass hybrid restorations were missing; three were due to bulk and one was due to proximal fracture at 12 months. Only six restorations were scored as bravo at baseline and at the six-, 12-, 18-, and 24-month recalls for color (p&lt;0.05). No significant differences were observed between the two restorative materials for the other criteria evaluated (p&gt;0.05). SEM observations exhibited acceptable surface and marginal adaptation characteristics for both restorative materials at 24 months.

Conclusions:
Although glass hybrid restorations showed significant mismatch in color, both restorative materials exhibited successful performance for the restoration of large Class II cavities after 24 months.
PENGARUH KOMPOSISI SERAT KELAPA TERHADAP TEMPERATUR GESEK BAHAN KOPLING GESEK KENDARAAN
Authors: Purboputro Pramuko Ilmu 
Published: October 2019

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh komposisi bahan dengan menggunakan fraksi berat serat kelapa, serbuk tembaga, fiberglass dengan resin phenolic terhadap keausan dan kekerasan specimen kampas kopling dan membandingkannya dengan kampas kopling yang sudah ada di pasaran Special Genuine Part (SGP ).Bahan yang digunakan dalam penelitian ini adalah serat kelapa, serbuk tembaga, fiberglass, dan resin phenolic. Pembuatan dilakukan dengan proses kompaksi, dengan gaya sebesar 2 ton dan ditahan selama 60 menit. Setelah mencapai holding time yang diinginkan, dies (cetakan) dimasukkan kedalam oven dan dilakukan proses sintering dengan suhu 800 C selama 40 menit dan specimen dikeluarkan dari cetakan. Setelah didapat tiga specimen kampas kopling variasi serart kelapa, serbuk tembaga, dan fiberglass lalu dilakukan proses pengujian kekerasan Brinell dengan standar ASTM F 1957-99 dan pengujian keausan dengan standar ASTM D 3702-94 kemudian dilakukan foto makro untuk melihat kepadatan dan sifat masing-masing bahan penyusun specimen kampas kopling. Hasil pengujian ini menunjukkan bahwa variasi 1 memiliki temperatur rata-rata yang paling tinggi yaitu dengan 77,70C dan yang paling rendah adalah variasi 2 yaitu 710C. Hasil temperatur gesek terendah adalah 77oC pada variasi 2pada kondisi kering. Pada kondisi basah temperatur gesek terendah adalah 47,7oC pada variasi 3.