bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of immune-related adverse events associated with ipilimumab and nivolumab in a single center.
Authors: Rapoport Bernardo Leon , Smit Teresa , van Eeden Ronwyn 
Published: November 2019

91 Background: Anti-programmed cell death receptor-1 (PD-1) and anti-CTLA4 antibodies represent an effective anti-cancer. Ipilimumab and nivolumab can induce immune-related adverse events (IrAEs). These IrAEs affect skin, gastrointestinal tract, liver, endocrine system and other organ systems. Life-threatening and fatal irAEs have been reported; adequate diagnosis and management are essential. Methods: A retrospective review of data from 40 patients (pts) records were used to describe the IrAE’s associated with 15 pts treated with ipilimumab and 25 pts treated with nivolumab. Results: A total of 40 pts (25 males and 15 females) were included in the analysis. The median age was 63 years (range 30 - 85 years). The performance status (PS) ranged from 0 to 2, with a median PS of 1. In total, 3 pts with metastatic melanoma, 18 with non small cell lung cancer (NSCLC), 2 with renal cell carcinoma and 2 with Hodgkin’s disease were treated with nivolumab and 15 with metastatic melanoma received ipilimumab. A total of 167 cycles of nivolumab (median = 4, range 1-16) and 60 cycles of ipilimumab (median = 4 cycles, range 1-4 cycles) were administered. Seven IrAEs are described in 19 pts treated with ipilimumab. These include endocrinopathy in 3 pts (hypophysitis in pt and hyphothyroidsm in 2 pts), colitis in 3 pts (1 required infliximab) and hepatitis in 1 pt. Among the pts treated with nivolumab 7 IrAEs were documented. These included pneumonitis in 2 pts, skin rash in 3 pts, mild diarrhea in 1 pt and mild uveitis in 1 pt. Additionally, 3 chest infections were documented including a case of pulmonary tuberculosis in a pt with NSCLC. Conclusions: Anti-PD1 and anti-CTLA4 antibodies can induce a plethora of irAEs. Colitis was more common with ipilimumab while pneumonitis more common with nivolumab. The knowledge of IrAE’s will allow prompt diagnosis and improve the management resulting in decreased morbidity.
Efficacy and Safety of Semaglutide for Type 2 Diabetes by Race and Ethnicity: A Post Hoc Analysis of the SUSTAIN Trials
Authors: DeSouza Cyrus , Cariou Bertrand , Garg Satish , Lausvig Nanna , Navarria Andrea , Fonseca Vivian 
Published: November 2019

Abstract

Context
Variations in the prevalence and etiology of type 2 diabetes (T2D) across race and ethnicity may affect treatment responses. Semaglutide is a glucagon-like peptide-1 analog approved for once-weekly, subcutaneous treatment of T2D.

Objective
To compare semaglutide efficacy and safety in race and ethnicity subgroups across the SUSTAIN trials.

Design
Post hoc analysis of data from phase 3 randomized SUSTAIN 1–5 and 7 (pooled), and SUSTAIN 6 trials.

Participants
3074 subjects (SUSTAIN 1–5 and 7) and 1648 subjects (SUSTAIN 6).

Interventions
Semaglutide 0.5 or 1.0 mg, placebo, or active comparator (sitagliptin 100 mg, exenatide extended release 2.0 mg, insulin glargine 100IU/ml and dulaglutide 0.75 or 1.5 mg).

Main Outcome Measures
Change in hemoglobin A1C (HbA1c) and body weight from baseline to weeks 30, 40 and 104, and other efficacy and safety endpoints.

Results
HbA1c was reduced from baseline by 1.0 to 1.5 percentage points and 1.3 to 2.0 percentage points, and body weight was reduced by 2.3 to 4.7 kg and 3.6 to 6.1 kg with semaglutide 0.5 and 1.0 mg, respectively, across race and ethnicity subgroups. Minor changes in blood pressure and lipid profiles were observed. Adverse events (AEs) were reported in similar proportions of subjects across trials. More Asian versus other race subgroups discontinued treatment prematurely due to AEs. The most commonly reported AEs were gastrointestinal disorders.

Conclusions
In this SUSTAIN trials post hoc analysis, semaglutide was associated with consistent and clinically relevant reductions in HbA1c and body weight in subjects with T2D, with minor variations in efficacy and safety outcomes associated with race or ethnicity.
Teaching the Environmental Humanities
Authors: O’Gorman Emily , van Dooren Thom , Münster Ursula , Adamson Joni , Mauch Christof , Sörlin Sverker , Armiero Marco , Lindström Kati , Houston Donna , Pádua José Augusto , Rigby Kate , Jones Owain , Motion Judy , Muecke Stephen , Chang Chia-ju , Lu Shuyuan , Jones Christopher , Green Lesley , Matose Frank , Twidle Hedley , Schneider-Mayerson Matthew , Wiggin Bethany , Jørgensen Dolly 
Published: November 2019

AbstractThis article provides the first international overview and detailed discussion of teaching in the environmental humanities (EH). It is divided into three parts. The first offers a series of regional overviews: where, when, and how EH teaching is taking place. This part highlights some key regional variability in the uptake of teaching in this area, emphasizing important differences in cultural and pedagogical contexts. The second part is a critical engagement with some of the key challenges and opportunities that are emerging in EH teaching, centering on how the field is being defined, shared concepts and ideas, interdisciplinary pedagogies, and the centrality of experimental and public-facing approaches to teaching. The final part of the article offers six brief summaries of experimental pedagogies from our authorship team that aim to give a concrete sense of EH teaching in practice.
Trans/Coalitional Love-Politics
Authors: Chaudhry V Varun 
Published: November 2019

Abstract
This essay works at the intersection of black feminism and trans studies to reflect on the radical possibilities for the futures of transgender studies and politics. Drawing on ethnographic data with a large-scale LGBTQ service organization, and focusing specifically on an example of the backlash that a black cisgender- and queer-identified woman received for coordinating a transgender-focused event, the article interrogates the ways in which the cisgender/transgender binary, pervasive in trans studies and trans organizing, counterintuitively reinforces the racialized gendered subjugation of black women. To circumvent the subjugation of black feminine bodies and thus harness the radical potential of trans studies and organizing, the author proposes a conception of trans coalitional love-politics. This is a reading and political practice that explodes the cis/trans binary and thus imagines more robust possibilities for racialized gendered justice.
Deviant Care for Deviant Futures
Authors: Hwang Ren-yo 
Published: November 2019

AbstractThis article introduces the concept of carceral care as those public-facing “do-better” penal practices, policies, and material actions used to ward off future investigation of underlying institutional violences of carceral spaces. As a model for denaturalizing carceral care, time, space, and the perpetuity of reform, it explores theories of deviant care, mutual aid, and QTBIPoC radical relationalism. It investigates how inhabiting deviance is a necessary care practice as modeled every day by queer bonds of survival, particularly from within the confines of carceral spaces. Based on relationships built over the last four years with trans women of color organizing inside a “male-designated” state prison in Corcoran, California, this article connects questions of deviant care as the refusal of the diagnosable and individuated self through queer black/indigenous feminist of color resistance and radical thought.
Synthesis and maintenance of lipid droplets are essential for mouse preimplantation embryonic development
Authors: Aizawa Ryutaro , Ibayashi Megumi , Tatsumi Takayuki , Yamamoto Atsushi , Kokubo Toshiaki , Miyasaka Naoyuki , Sato Ken , Ikeda Shuntaro , Minami Naojiro , Tsukamoto Satoshi 
Published: November 2019

ABSTRACT
Lipid droplets (LDs), which are ubiquitous organelles consisting of a neutral lipid core coated with a phospholipid monolayer, play key roles in the regulation of cellular lipid metabolism. Although it is well known that mammalian oocytes and embryos contain LDs and that the amount of LDs varies among animal species, their physiological functions remain unclear. In this study, we have developed a method based on two-step centrifugation for efficient removal of almost all LDs from mouse MII oocytes (delipidation). We found that delipidated MII oocytes could be fertilized in vitro, and developed normally to the blastocyst stage even when the embryos were cultured in the absence of a fatty acid supply. LDs were newly synthesized and accumulated soon after delipidation, but chemical inhibition of long chain acyl-CoA synthetases (ACSLs) blocked this process, resulting in severe impairment of early embryonic development. Furthermore, we found that overabundance of LDs is detrimental to early embryonic development. Our findings demonstrate the importance of synthesis and maintenance of LDs, mediated in part by ACSL activity, during preimplantation embryonic development.
Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model
Authors: Elias Martina S. , Wright Sheila C. , Nicholson William V. , Morrison Kimberley D. , Prescott Alan R. , Ten Have Sara , Whitfield Phillip D. , Lamond Angus I. , Brown Sara J. 
Published: November 2019

Background:Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Skin as an organ that can be modelled using primary cellsin vitroprovides the opportunity for selected genetic effects to be investigated in detail.Methods:Primary human keratinocytes and donor-matched primary fibroblasts from healthy individuals were used to create skin organoid models with and without siRNA-mediated knockdown ofFLG. Biological replicate sets of organoids were assessed using histological, functional and biochemical measurements.Results:FLGknockdown leads to subtle changes in histology and ultrastructure including a reduction in thickness of the stratum corneum and smaller, less numerous keratohyalin granules. Immature organoids showed some limited evidence of barrier impairment withFLGknockdown, but the mature organoids showed no difference in transepidermal water loss, water content or dye penetration. There was no difference in epidermal ceramide content. Mass spectrometry proteomic analysis detected >8000 proteins per sample. Gene ontology and pathway analyses identified an increase in transcriptional and translational activity but a reduction in proteins contributing to terminal differentiation, including caspase 14, dermokine, AKT1 and TGF-beta-1. Aspects of innate and adaptive immunity were represented in both the up-regulated and down-regulated protein groups, as was the term ‘axon guidance’. Conclusions:This work provides further evidence for keratinocyte-specific mechanisms contributing to immune and neurological, as well as structural, aspects of skin barrier dysfunction. Individuals with filaggrin deficiency may derive benefit from future therapies targeting keratinocyte-immune crosstalk and neurogenic pruritus.
Assessment of the quality of life after surgical treatment of patients with primary postoperative ventral hernia in conditions of comorbidity
Authors: Piatnochka V. I. , Kornaha S. I. , Kohan R. S. 
Published: November 2019

Improving the quality of life of patients after surgical treatment of primary and postoperative ventral hernias is a very urgent problem, which is explained by the increasing number of patients with this pathology, high rates of recurrences and complications in hernioplasty (4.3–46 %).Objective. Improving the results of surgical treatment of patients with primary and postoperative ventral hernia under comorbidity by performing a comparative evaluation of different types of hernioplasty performed using quality of life indicators in the early and late postoperative period.Materials and methods. The quality of life indicators were analyzed based on the SF-36 questionnaire after surgical treatment of 1419 patients with primary and postoperative ventral hernia under conditions of comorbidity, operated with patient’s own tissue hernioplasty, onlay, sublay, inlay, CST techniques. The total number of patients questioned on the SF-36 questionnaire on quality of life was527. In relation to all patients operated on by different methods of hernioplasty in the main group and comparison group (1419 persons), the number of patients questioned in the postoperative period was 37.14 %, ie more than a third of all patients operated for the whole period of the study (2001–2017). pp). This demonstrates the representativeness of this sample population.Results. The results of the study were found to be the most optimal for the use in the surgical treatment of primary ventral hernia (PVH) and postoperative ventral hernia (POVH) sublay and inlay technique, taking into account the lowest incidence of recurrence in their performance and the fastest recovery of the basic parameters of life of patients and quality of life in the postoperative period.The indicators of physical and psychological components of health at this time of the survey were significantly higher in patients of the main group. This is probably due to the recorded recurrence of PVH [8] after own tissue hernia. Determination of health components after 1 year showed a slight improvement in both indicators relative to the previous survey data in all study groups (p <0.05).The psychological component of health was significantly higher in patients in the main group than in patients in the comparison group. (51.73±6.37) points compared with the results of the 6-month survey, and slightly improved ((46.81±2.59) points) in the comparison group (p> 0.05).Conclusions. The results of the study seriously suggest that there is a strong correlation between the type of surgical hernioplasty techniques used in patients with PVH and POVH the incidence of disease recurrence and, as a consequence, the quality of life of patients – an important comprehensive determinant of health.
From melancholic to happy immigrant: Staging simpleton in the comedies of migration
Authors: Meerzon Yana 
Published: November 2019

Abstract
This article examines devices of comedy, laughter and dramatic humour as technologies of ethics when it comes to staging migration in contemporary theatre. Looking at a tragic farce Hunting Cockroaches (1985), written by the Polish theatre artist Janusz Głowacki during his American exile, and a domestic melodrama , written by a Korean Canadian Ins Choi, this article examines comedy as a particular dramatic model that can challenge staging migrants as agentless and voiceless victims. It asks, what happens when theatre artists begin to use stereotype to stage the trauma of displacement? To what extent is comedy truly capable of rendering the complexity of migration? And how ethical can the comedic representation of a migrant be?
RUMPUT LAUT: ANTIOKSIDAN ALAMI PENANGKAL RADIKAL BEBAS
Authors: Dwimayasanti Rany 
Published: November 2019

SEAWEED: NATURAL ANTIOXIDANT FREE RADICAL ANTIDOTE. Free radicals are the result of various complex chemical processes in the body, in form of oxidation process, cell metabolism, UV irradiation, environmental pollution such as cigarette smoke, and other pollutants. The effects of free radicals can be prevented by addition of antioxidants endogenously from outside the body. Seaweed is one source of natural antioxidants that is safe for the body. Seaweed contains bioactive compounds that are able to prevent free radicals such as carotenoids, phenols, vitamins and minerals.
ASPEK BIOLOGI DAN ABLASI MATA PADA UDANG WINDU Penaeus monodon SUKU PENAEIDAE (DECAPODA: MALACOSTRACA)
Authors: Pratiwi Rianta 
Published: November 2019

THE ASPECTS OF BIOLOGY ANDEYE ABLATION ON SHRIMP Penaeus monodon PENAEIDAE (DECAPODA: MALACOSTRACA). A qood quality of seeds (fry) is a very important production component to support the shrimp farming activities in ponds. The quantity and quality of shrimp seeds are largely determined by hatchery products obtained from the quality of the broodstock used. The provision of the broodstock is the beginning of the seed production activities and is one of the factors that determines the quality and quantity of the production. The growing demand for mature gonad shrimp is a big problem for shrimp farmers, due to the ability of windu shrimp to spawn in the nature (ripe gonad naturally) takes relatively long time. Therefore, the eye ablation process can accelerate the process of gonad maturity. This article describes some aspects that should be understood in conducting windu shrimp farming as well as explanations of ablation process.
OS CONCEITOS DE INTELIGÊNCIA E DE DEFICIÊNCIA INTELECTUAL: AS MESMAS ORIGENS?
Authors: Caetano Andressa Mafezoni , Pletsch Márcia Denise 
Published: November 2019

Neste artigo discutem-se as origens dos conceitos de inteligência e de deficiência intelectual a partir do contexto europeu e suas influências no cenário escolar brasileiro. Trata-se uma pesquisa bibliográfica com base nos estudos de Alfred Binet sobre a medida de inteligência e “anormalidade” em diálogo com a literatura científica contemporânea. A partir das análises realizadas, evidenciamos a influência do debate europeu na Educação Especial brasileira. Como considerações finais, mostramos que esses conceitos têm as mesmas origens e foram forjados no contexto de uma ciência médico-psicológica, justificada por um ideário republicano como “solução” dos problemas educacionais brasileiros da época.
Strategies to digitalize inert health practices: The gamification of glucose monitoring
Authors: Neumann Caterina Joelle , Kolak Tereza , Auschra Carolin 
Published: November 2019

Abstract
The ongoing digital transformation will potentially change traditional health care practices fundamentally. However, change agents usually face serious challenges arising from the highly institutionalized nature of this industry. Using the gamification of glucose monitoring as part of diabetes care as an example, this paper focuses on strategies to transform health care, allowing not only to cope with, but also to change this context: gamification encourages behavioral changes in patients, establishes new roles between patients and providers, and thereby elevates patient empowerment.
On the Thermodynamics of Micellizationof Oppositely Charged Surfactants in the Presence of Organic Additives in the Aqueous Medium
Authors: Kumar Girish , Chauhan Mohinder Singh , Kumar Anil 
Published: November 2019

Abstract
To investigate the effect of additives urea and thiourea, on the micellization behavior of sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB), detailed conductance measurements were carried out in aqueous media at different temperatures. The critical micelle concentration (CMC), determined from the discontinuity in the plots of molar conductance versus square root of concentration, indicated an inhibitory effect of urea and thiourea on micelle forming ability of the surfactants SDS and CTAB in the range of composition studied. The demicellizing effect of urea has been found to be more pronounced in SDS than CTAB. These observations are further augmented by the evaluation of thermodynamic parameters of micellization. A negative change in enthalpy of micellization (

Δ

H
m
∘

$\Delta{\text{H}}_{\text{m}}^{\circ}$

) indicates a strong interaction between water and the additives and a positive change observed in entropy of micellization (

Δ

S
m
∘

$\Delta{\text{S}}_{\text{m}}^{\circ}$

) manifest, that the micellization is an entropy-driven process. Further

Δ

H
m
∘

$\Delta{\text{H}}_{\text{m}}^{\circ}$

and

Δ

S
m
∘

$\Delta{\text{S}}_{\text{m}}^{\circ}$

change in mutually compensating manner, so that

Δ

G
m
∘

<
0

$\Delta{\text{G}}_{\text{m}}^{\circ} < 0$

is not significantly affected. Finally, the counterion binding values (β) obtained for SDS and CTAB remain practically constant from 0.6 to 0.8 between 25 °C and 45 °C indicate that the size and shape of micelle remain essentially constant. Moreover, the increase in

Δ

G
II
∘

$\Delta{\text{G}}_{{\text{II}}}^{\circ}$

values, which represent the effect of co-solvent or additive on micellization, substantiates the above observations. Many early works has investigated the micellization behavior of surfactants using a fixed additive composition. However, in this study, variable aqueous compositions of urea (0.30–1.78 wt%) and thiourea (0.24–1.41 wt%) have been considered.
Experimental Study of Modeling Partially Drained Dense Sand Behavior in Monotonic Triaxial Compression Loading Tests
Authors: Suzuki Y. , Carotenuto P. , Dyvik R. , Jostad H. P. 
Published: November 2019

Abstract
Sand behavior is significantly affected by the drainage conditions being either fully drained, partially drained, or undrained. Partially drained conditions are often encountered in reality; however, partial drainage effects are not commonly considered at a soil element level. As a common soil element test, triaxial testing is carried out with either fully drained or undrained conditions for the shearing phase, as specified according to the soil type and design application. In this study, a series of monotonic triaxial compression tests were performed under various drainage conditions with a special filter device to investigate partially drained behavior of dense sand. Partially drained behavior resulted in simultaneous excess pore water pressure generation and volumetric strain and behaved more similar to the undrained condition at the beginning of shearing and more similar to the fully drained condition at the large strains. Using three different degrees of drainage induced by three filter devices with different steady-state flow capacity and different shearing strain rates suggest that a ratio of the axial strain rate to the filter flow capacity can be used as a unique parameter to represent degree of drainage in a partially drained test.
A Self-Organizing Evolutionary Method to Model and Optimize Correlated Multiresponse Metrics for Additive Manufacturing Processes
Authors: Aljarrah Osama , Li Jun , Huang Wenzhen , Heryudono Alfa , Bi Jing 
Published: November 2019

Abstract
The use of robust multiresponse constrained optimization techniques in which multiple-objective responses are involved is becoming a crucial part in additive manufacturing (AM) processes. Common and popular techniques, in most cases, rely on the assumption of independent responses. In practice, however, many of the desired quality characteristics can be correlated. In this work, we propose a technique based on three ingredients: hybrid self-organizing (HSO) method, desirability function (DF), and evolutionary algorithms to analyze, model, and optimize the multiple correlated responses for the fused deposition modeling (FDM) process, one of the most popular AM technologies. The multiobjective functions are formulated by employing the HSO method and DF, where structural integrity and process efficiency metrics are considered for the data-driven correlated multiresponse models. Subsequently, layer thickness, nozzle temperature, printing speed, and raster angles are taken as process parameters (decision variables). The operational settings and capabilities for the FDM machine are defined as boundary constraints. Different EA algorithms, the nondominated sorting genetic algorithm, and the multiobjective particle swarm optimization method, are then deployed to model the AM criteria accordingly to extract the Pareto-front curve for the correlated multiresponse functions. FDM experimental design and data collection for the proposed method are provided and used to validate our approach. This study sheds light on formulating robust and efficient data-driven modeling and optimizations for AM processes.