bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Analysis of FDA Drugs as P2X4 Modulators for the Treatment of Alcohol Use Disorder
Authors: Reyes‐Espinosa Francisco , Nieto‐Pescador María G. , Bocanegra‐García Virgilio , Lozano‐Guzmán Eduardo , Rivera Gildardo 
Published: June 2020

AbstractRecent studies have shown the potential application of ivermectins in the treatment of alcohol use disorder (AUD). Ivermectin is a positive allosteric modulator (PAM) of P2X4R and this molecule exerts its action in the transmembrane region (known as the TM region) of trimeric channel structure (the pocket formed by Asp331, Met336, Trp46, Trp50, and Tyr42). The aim of this study is to identify FDA drugs with potential PAM properties, by exploring the P2X4Rs from four organisms (Danio rerio, Mus musculus, Rattus norvegicus, and Homo sapiens). The in silico study consists of carrying out the molecular docking of 1656 FDA‐approved drugs on the structure of P2X4R, using the commercially available compounds from the ZINC15 database for virtual screening. To strengthen the reliability of the results, two docking protocols were used involving the use of two programs, Autodock 4.2 and Autodock Vina. Nine FDA drugs with potential PAM properties were identified. In addition, eight molecules with potential negative allosteric modulator (NAM) action, and 13 molecules with potential allosteric modulator (AM) action were identified. The FDA drugs identified in this study with PAM, NAM, and AM action, shared in the P2X4Rs of the four organisms, can provide a guideline to proceed with research concerning new drugs for the study and treatment of AUD.
Stepped‐impedanceslottedmicrostrip‐fedpatch antenna foron‐metal radio frequency identificationapplications
Authors: Deif Samier , Olokede Seyi S. , Nosrati Mehdi , Daneshmand Mojgan 
Published: June 2020

AbstractThe paper reports the bandwidth enhancement of a microstrip slot antenna for on‐metal RFID applications. Microstrip patch with a single conductive layer as wideband and conformal antenna is investigated. The proposed bandwidth enhancement is based on stepped‐impedance slot resonator integrated with an inset‐fed microstrip patch. Slots of different electrical lengths and impedances are configured to generate their respective and distinct resonances, and are subsequently overlapped to create wideband. Equivalent circuit modeling to characterize the antenna in terms of electrical lengths and impedances with respect to their resonances are investigated and reported. These resonances are optimized to overlap using certain numerical equations and the commercially available 2D/3D EM solvers. The resulting antenna is thereafter stamped on the external coating of the pipeline of an RFID specific application for signal monitoring and pipeline integrity.
Primary cancer location predicts predominant level of brachial plexopathy
Authors: McNeish Brendan L. , Zheutlin Alexander R. , Richardson James K. , Smith Sean R. 
Published: June 2020

AbstractBackgroundChanges in radiation therapy practice and cancer incidence bring into question prior evidence suggesting that radiation therapy predominantly injures the brachial plexus upper trunk, while tumor invasion typically injures the lower trunk.MethodsWe reviewed electrodiagnostic brachial plexopathy reports in cancer survivors for predominant trunk involvement, injury mechanism (tumor invasion vs radiation), and primary cancer location.ResultsFifty‐six cases of cancer‐associated brachial plexopathy were identified. There was no relationship between injury mechanism and brachial plexus injury level. However, primary cancer location superior/inferior to the clavicle increased the odds of predominantly upper/lower trunk involvement by a factor of 60.0 (95% confidence interval: 7.9, 1401, respectively).ConclusionsCancers superior/inferior to the clavicle increase the likelihood of predominantly upper/lower trunk plexopathy, respectively, regardless plexus injury mechanism. These findings contrast with older work, possibly due to more precise radiation therapy techniques and increased incidence of radiosensitive head and neck cancers.
Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting‐State fMRI
Authors: Zhang Peng , Wu Guo‐wei , Yu Feng‐xia , Liu Yang , Li Meng‐yi , Wang Zheng , Ding He‐yu , Li Xiao‐shuai , Wang Hao , Jin Mei , Zhang Zheng‐yu , Zhao Peng‐fei , Li Jing , Yang Zheng‐han , Lv Han , Zhang Zhong‐tao , Wang Zhen‐chang 
Published: June 2020

ObjectiveThis study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior.MethodsA total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0‐T MRI. Amplitude of low‐frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting‐state fMRI and Resting‐State fMRI Data Analysis Toolkit (REST).ResultsThe group with obesity showed increased amplitude of low‐frequency values in left fusiform gyrus/amygdala, inferior temporal gyrus (ITG), hippocampus/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus/amygdala and left ITG, right caudate and left fusiform gyrus/amygdala, and right caudate and left hippocampus/parahippocampal gyrus. Dutch Eating Behavior Questionnaire‐Emotional scores were positively correlated with FC between left hippocampus/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus/amygdala and left ITG.ConclusionsThe study indicated the reorganized neural network presented as a bilateral cross‐regulation pattern across hemispheres between reward and various appetite‐related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.
Evaluation of interfacial compatibility in wood flour/polypropylene composites by using dynamic thermomechanical analysis
Authors: Xiao Feng , Zhu Lizhi , Yu Lili 
Published: June 2020

AbstractWood‐plastic composites (WPCs) manufactured from tomentose wood flour and polypropylene (PP) was studied in this article. The interfacial compatibility before and after the addition of the coupling agent was evaluated by dynamic thermodynamic analysis, Fourier transforms infrared (FT‐IR), and differential scanning calorimetry (DSC). The effects of the coupling agent on the interfacial compatibility of WPCs were studied. The results indicated that the bending properties of the composite material after adding the coupling agent are greater than that without the coupling agent. And WPCs have the best performance when the coupling agent is added at 2%. The storage modulus E' of the composite material decreases with the increase in temperature and increases with the increase of frequency. At high frequencies, the composite has higher structural stability. After the coupling agent is added, the storage modulus E' significantly improved, and the interface bonding strength has increased accordingly. After the coupling agent is added, the apparent activation energy and the glass transition temperature of the composite material increase during the relaxation process.
The effect of core geometry on flexural stiffness and transverse shear rigidity of weight‐wise identical corrugated core sandwich panels reinforced with 3D flat spacer knitted fabric
Authors: Abedzade Atar Hamid , Zarrebini Mohammad , Hasani Hossein , Rezaeepazhand Jalil 
Published: June 2020

AbstractThis article aims to evaluate the effect of core geometry on flexural stiffness and transverse shear rigidity of corrugated core sandwich panels both experimentally and numerically. Using vacuum‐assisted resin transfer molding (VARTM) method, three composite sandwich panels reinforced with 3D weft knitted spacer fabric with rectangular, hat‐type (trapezoidal) and triangular cross‐sectional geometries were produced. In order to eliminate weight variation among the produced sandwich panel samples, the unit cell dimensions, core wall to skin angle, and the yarn count used to knit the core wall were carefully chosen. Results pointed to existence of statistically significant difference between the load‐carrying capacity and transverse shear rigidity in the direction of corrugation of the structures. It was concluded that triangular and rectangular structures have the highest and lowest load‐carrying capacity, transverse shear rigidity, and core shear modulus in the direction of corrugation, respectively.
Mechanical, thermal, and micro‐ and nanostructural properties of polyvinyl chloride/graphene nanoplatelets nanocomposites
Authors: Mindivan Ferda , Göktaş Meryem , Dike Ali S. 
Published: June 2020

AbstractThis article describes micro‐ and nanostructural, mechanical, and thermal properties of nanocomposites based on polyvinyl chloride (PVC) and graphene nanoplatelets (GNP). The primary objective of this study was to extend restricted application area of PVC due to its low thermal stability and limited mechanical properties. GNP‐filled PVC nanocomposites were prepared (0, 0.1, 0.3, 0.5, and 1.0 wt%) by colloidal blending method and characterized in detail. The highest value of the tensile strength 13.73 MPa (an increase of 58%) and the highest value of microhardness 83.42 MPa (an increase of 82%) were obtained with GNP loading content of 0.5 wt% compared neat PVC. The mechanical properties started to decrease at loading higher than 0.5 wt%; however, the thermal properties continued to increase. The differential scanning calorimetry and Fourier transform infrared analysis results of this nanocomposite confirmed that the increase in glass transition temperature from 34.99°C to 44.36°C and the decrease in the height of functional groups peaks proved to prevented segmental relaxation and intermolecular vibrations of PVC, respectively. Thermogravimetric analysis results were showed that the percentage of carbonaceous residue increased to 15.77% by increasing the GNP content from 0.1 to 0.5 wt%. As a result, the best GNP loading was at 0.5 wt% for PVC/GNP nanocomposites where mechanical and thermal properties of PVC/GNP were both enhanced.
ProTrack: An Interactive Multi‐Omics Data Browser for Proteogenomic Studies
Authors: Calinawan Anna Pamela , Song Xiaoyu , Ji Jiayi , Dhanasekaran Saravana Mohan , Petralia Francesca , Wang Pei , Reva Boris 
Published: June 2020

AbstractThe Clinical Proteomic Tumor Analysis Consortium (CPTAC) initiative has generated extensive multi‐omics data resources of deep proteogenomic profiles for multiple cancer types. To enable the broader community of biological and medical researchers to intuitively query, explore, and download data and analysis results from various CPTAC projects, a prototype user‐friendly web application called “ProTrack” is built with the CPTAC clear cell renal cell carcinoma (ccRCC) data set (http://ccrcc.cptac-data-view.org). Here the salient features of this application which provides a dynamic, comprehensive, and granular visualization of the rich proteogenomic data is described.
Particles with Magnetic Patches: Synthesis, Morphology Control, and Assembly
Authors: Yammine Elham , Souaid Eddy , Youssef Sami , Abboud Maher , Mornet Stéphane , Nakhl Michel , Duguet Etienne 
Published: June 2020

AbstractThe concept of patchy particles is revolutionizing the research field of colloidal assembly, by the design of particles whose surface is purposely patterned to promote attractive interactions with their neighbors in limited number, and in privileged and programmed directions. The idea of magnetic patches makes it possible to imagine assemblies not only spontaneous by simple magnetic coupling but also triggered and canceled at will due to external magnetic fields. This review shows that studies published until now mainly deal with particles with a single magnetic patch, often called Janus particles. The very diverse synthetic routes have been brought together into four main strategies, covering the size range from 100 nm to 100 µm. Their assembly capacity is described both from experimental and simulation viewpoints. The orientation of the magnetic moment of the patch and its decentering extent with respect to the particle are the key parameters for controlling the morphology of clusters, loops, staggered chains, double chains, helices, microtubes, etc. The review offers some perspectives to generalize these studies to multipatch particles, examples of which are still too rare, and to make assemblies sustainable, especially after the removal of the structuring magnetic fields.
Weaning from noninvasive ventilation and high flow nasal cannula in bronchiolitis: A survey of practice
Authors: Suzanne Marie , Amaddeo Alessandro , Pin Isabelle , Milési Christophe , Mortamet Guillaume 
Published: June 2020

AbstractRationalThis study aims to describe the current weaning practices from any type of noninvasive support in infants with bronchiolitis, in terms of weaning procedures, weaning initiation and weaning failure criteria.Working HypothesisNo information regarding the weaning practices is currently available and there may be a wide variability of strategies.Study DesignA cross‐sectional electronic survey.MethodologyThe survey was distributed to physicians from five French‐speaking countries with key roles in pediatric intensive care units (PICUs).ResultsResponses were obtained from 29 PICUs from five French‐speaking countries. A written weaning protocol was available in three pediatric centers (10%) and nurses had a key role in the weaning process in 72% of centers. The sudden weaning was the most commonly used procedure, no matter the type of noninvasive ventilatory (NIV) support. The most commonly used criteria for weaning initiation and weaning failure were the degree of respiratory distress, the occurrence of apneas and the fraction of inspired oxygen (FiO2). The thresholds commonly used for weaning initiation criteria were (a) none or a slight use of accessory muscles; (b) FiO2 less than equal to 40%, (c) respiratory rate less than 60 per minute, (d) no apnea, (e) blood pH more than 7.30, and (f) partial pressure of venous carbon dioxide less than equal to 50 mm Hg.ConclusionIn infants with bronchiolitis requiring NIV support, the sudden weaning procedure was the most commonly used strategy. We observed a certain consensus on criteria for weaning initiation. These findings should help in building nurse‐driven weaning protocols, but prospective studies remain needed to assess the best weaning strategy in infants with bronchiolitis‐related acute respiratory failure.
Predictions of Systemic, Intracellular, and Lung Concentrations of Azithromycin With Different Dosing Regimens Used in COVID‐19 Clinical Trials
Authors: Hughes Jim H. , Sweeney Kevin , Ahadieh Sima , Ouellet Daniele 
Published: June 2020

Azithromycin (AZ), a broad‐spectrum macrolide antibiotic, is being investigated in patients with coronavirus disease 2019 (COVID‐19). A population pharmacokinetic model was implemented to predict lung, intracellular poly/mononuclear cell (peripheral blood monocyte (PBM)/polymorphonuclear leukocyte (PML)), and alveolar macrophage (AM) concentrations using published data and compared against preclinical effective concentration 90% (EC90) for severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). The final model described the data reported in eight publications adequately. Consistent with its known properties, concentrations were higher in AM and PBM/PML, followed by lung tissue, and lowest systemically. Simulated PBM/PML concentrations exceeded EC90following the first dose and for ~ 14 days following 500 mg q.d. for 3 days or 500 mg q.d. for 1 day/250 mg q.d. on days 2–5, 10 days following a single 1,000 mg dose, and for > 20 days with 500 mg q.d. for 10 days. AM concentrations exceeded the 90% inhibitory concentration for > 20 days for all regimens. These data will better inform optimization of dosing regimens for AZ clinical trials.
Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
Authors: Kooshki Akram , Tofighiyan Tahereh , Rastgoo Neda , Rakhshani Mohammad Hassan , Miri Mohammad 
Published: June 2020

AbstractThis study aimed to evaluate the effects of Nigella sativa oil on serum level of systemic inflammation, oxidative stress, fasting blood glucose (FBG), and lipid profile in patients with type 2 diabetes mellitus (T2DM). This double‐blind randomized clinical trial study was based on 50 patients with T2DM. Patients were allocated randomly to either N. sativa oil or placebo groups. The intervention group received 1,000 mg N. sativa oil as two capsules, daily for 8 weeks, whereas the placebo group received a corresponding placebo. At baseline and the end of the study, 5 ml blood was collected from each patient after 14‐hour fasting for measuring serum C‐reactive protein (hs‐CRP), malondialdehyde (MDA), FBS, and lipid profile. Analyses covariance was performed to compare investigated parameters between two groups, controlled for relevant covariates. Using N. sativa supplement was significantly associated with decrease in FBS (p < .001), triglyceride (p < .001), total cholesterol (p < .001), low‐density lipoprotein cholesterol (p < .001), serum hs‐CRP, MDA (p < .001) and increase in serum level of high‐density lipoprotein cholesterol (p < .001) in intervention group compared with placebo group. Nigella sativa oil supplement has cardiovascular protective effects in patients with T2DM, by improving the lipid profile and glycemia, by reducing the C‐reactive protein level and the lipid peroxidation.
Innovative focused ultrasound‐based sealing method of flexible packaging films—Principles and characteristics
Authors: Koo Sin Lin Coralie , Oehm Lukas , Majschak Jens‐Peter 
Published: June 2020

A key process to package goods is the closure procedure. It ensures the good protection against the environment and vice versa. Ultrasonic sealing presents the advantage of converting locally ultrasound into heat, which is optimal for temperature sensitive goods. The disadvantages remain, however, the equipment cost, the noise generation, and the process sensitivity to materials. It is necessary to develop a sealing process to decrease the acquisition cost of the sealing equipment and cover a wide range of polymer films.This paper focuses on a new sealing method based on high‐intensity focused ultrasound. The principles and characteristics of this process are discussed and underpinned with experimental results.Both the acoustic and thermal effects of the sealing process are summarized. A study of the process parameter impact on the seam strength in static and dynamic operating is proposed. Low‐density polyethylene films with a carrier layer of bi‐oriented polypropylene and polyethylene terephthalate are used. A first test bench generates point‐shaped seam. The heat generation is recorded with an infrared thermography system. A second test bench, a horizontal form fill and seal machine, produces longitudinal seams. The seam quality is controlled by tensile test and tightness test.A quick heating of the polymer films is found. Point seams and longitudinal seams are successfully generated. The seams behave similarly to the ones generated with ultrasonic sealing process. However, the sealing velocity is limited to 3 m/min.This work provides a summary of the characteristics and principles of the new sealing method in packaging applications.
Intraoperative surgery room management: A deep learning perspective
Authors: Tanzi Leonardo , Piazzolla Pietro , Vezzetti Enrico 
Published: June 2020

AbstractPurposeThe current study aimed to systematically review the literature addressing the use of deep learning (DL) methods in intraoperative surgery applications, focusing on the data collection, the objectives of these tools and, more technically, the DL‐based paradigms utilized.MethodsA literature search with classic databases was performed: we identified, with the use of specific keywords, a total of 996 papers. Among them, we selected 52 for effective analysis, focusing on articles published after January 2015.ResultsThe preliminary results of the implementation of DL in clinical setting are encouraging. Almost all the surgery sub‐fields have seen the advent of artificial intelligence (AI) applications and the results outperformed the previous techniques in the majority of the cases. From these results, a conceptualization of an intelligent operating room (IOR) is also presented.ConclusionThis evaluation outlined how AI and, in particular, DL are revolutionizing the surgery field, with numerous applications, such as context detection and room management. This process is evolving years by years into the realization of an IOR, equipped with technologies perfectly suited to drastically improve the surgical workflow.
Examining micro‐change within and among science teachers' identities: A multiple case study
Authors: Hathcock Stephanie J. , Garner Joanna K. , Kaplan Avi 
Published: June 2020

AbstractWhereas science teachers often express initial enthusiasm about the student‐centered, reform‐oriented instructional strategies they encounter in professional development (PD), they rarely adopt them in practice. One possible obstacle is a mismatch between these strategies and teachers' beliefs about what is possible and desirable in their particular teaching contexts. In the current study, we investigated changes in teachers' beliefs about practices within a PD context, and consider beliefs about practice as one component within teachers' overall professional role identity. Using the Dynamic Systems Model of Role Identity (DSMRI) as our theoretical framework, we analyzed pre‐PD, mid‐PD, and post‐PD interviews, daily written reflections, and responses to exploration and commitment prompts of four high school science teacher participants in an 8‐day, reform‐oriented summer institute. Teachers' experiences, changes in the content, structure and process of various components of their professional role identities, and their eventual endorsement or resistance to new practices, were framed by the dynamic interplay between their current science teacher role identity and other role identities. When discussing possibilities for action in subsequent teaching practices, alignment, and tensions within and between these role identities promoted or impeded changes in behavioral intentions. The findings highlight the importance of considering prior and current role identities when designing and evaluating PD contexts, and the complex and contextual nature of identity change among teachers.