bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infinite distances and the axion weak gravity conjecture
Authors: Grimm Thomas W. , van de Heisteeg Damian 
Published: March 2020

Abstract
The axion Weak Gravity Conjecture implies that when parametrically increasing the axion decay constants, instanton corrections become increasingly important. We provide strong evidence for the validity of this conjecture by studying the couplings of R-R axions arising in Calabi-Yau compactifications of Type IIA string theory. Specifically, we consider all possible infinite distance limits in complex structure moduli space and identify the axion decay constants that grow parametrically in a certain path-independent way. We then argue that for each of these limits a tower of D2-brane instantons with decreasing actions can be identified. These instantons ensure that the convex hull condition relevant for the multi-axion Weak Gravity Conjecture cannot be violated parametrically. To argue for the existence of such instantons we employ and generalize recent insights about the Swampland Distance Conjecture. Our results are general and not restricted to specific examples, since we use general results about the growth of the Hodge metric and the sl(2)-splittings of the three-form cohomology associated to each limit.
Brane dynamics from the first law of entanglement
Authors: Cooper Sean , Neuenfeld Dominik , Rozali Moshe , Wakeham David 
Published: March 2020

Abstract
In this note, we study the first law of entanglement in a boundary conformal field theory (BCFT) dual to warped AdS cut off by a brane. Exploiting the symmetry of boundary-centered half-balls in the BCFT, and using Wald’s covariant phase space formalism in the presence of boundaries, we derive constraints from the first law for a broad range of covariant bulk Lagrangians. We explicitly evaluate these constraints for Einstein gravity, and find a local equation on the brane which is precisely the Neumann condition of Takayanagi [6] at linear order in metric perturbations. This is analogous to the derivation of Einstein’s equations from the first law of entanglement entropy. This machinery should generalize to give local linearized equations of motion for higher-derivative bulk gravity with additional fields.
Abstinence from Masturbation and Hypersexuality
Authors: Zimmer Felix , Imhoff Roland 
Published: March 2020

AbstractDespite the lack of evidence for negative health effects of masturbation, abstinence from masturbation is frequently recommended as a strategy to improve one’s sexual self-regulation. We adopted a framework of perceived problems with pornography to collect first hints about whether abstinence from masturbation stems from a psychological and behavioral “addiction” or conflicting attitudes. In an online questionnaire survey recruited via a non-thematic Reddit thread (n = 1063), most participants reported that they had tried to be abstinent from masturbation. As visible from zero-order correlations and multiple linear regression, motivation for abstinence was mostly associated with attitudinal correlates, specifically the perception of masturbation as unhealthy. While there were associations with hypersexuality, no significant correlation with behavioral markers such as maximum number of orgasms was found. Higher abstinence motivation was related to a higher perceived impact of masturbation, conservatism, and religiosity and to lower trust in science. We argue that research on abstinence from masturbation can enrich the understanding of whether and how average frequencies of healthy behavior are pathologized.
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer
Authors: Andreano Kaitlyn J. , Wardell Suzanne E. , Baker Jennifer G. , Desautels Taylor K. , Baldi Robert , Chao Christina A. , Heetderks Kendall A. , Bae Yeeun , Xiong Rui , Tonetti Debra A. , Gutgesell Lauren M. , Zhao Jiong , Sorrentino Jessica A. , Thompson Delita A. , Bisi John E. , Strum Jay C. , Thatcher Gregory R. J. , Norris John D. 
Published: March 2020

Abstract
Purpose
The combination of targeting the CDK4/6 and estrogen receptor (ER) signaling pathways with palbociclib and fulvestrant is a proven therapeutic strategy for the treatment of ER-positive breast cancer. However, the poor physicochemical properties of fulvestrant require monthly intramuscular injections to patients, which limit the pharmacokinetic and pharmacodynamic activity of the compound. Therefore, an orally available compound that more rapidly reaches steady state may lead to a better clinical response in patients. Here, we report the identification of G1T48, a novel orally bioavailable, non-steroidal small molecule antagonist of ER.

Methods
The pharmacological effects and the antineoplastic mechanism of action of G1T48 on tumors was evaluated using human breast cancer cells (in vitro) and xenograft efficacy models (in vivo).

Results
G1T48 is a potent and efficacious inhibitor of estrogen-mediated transcription and proliferation in ER-positive breast cancer cells, similar to the pure antiestrogen fulvestrant. In addition, G1T48 can effectively suppress ER activity in multiple models of endocrine therapy resistance including those harboring ER mutations and growth factor activation. In vivo, G1T48 has robust antitumor activity in a model of estrogen-dependent breast cancer (MCF7) and significantly inhibited the growth of tamoxifen-resistant (TamR), long-term estrogen-deprived (LTED) and patient-derived xenograft tumors with an increased response being observed with the combination of G1T48 and the CDK4/6 inhibitor lerociclib.

Conclusions
These data show that G1T48 has the potential to be an efficacious oral antineoplastic agent in ER-positive breast cancer.
Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR
Authors: Adam Aziza A. A. , Jongejan Aldo , Moerland Perry D. , van der Mark Vincent A. , Oude Elferink Ronald P. , Chamuleau Robert A. F. M. , Hoekstra Ruurdtje 
Published: March 2020

AbstractHuman liver cell line HepaRG is a well-known source of human hepatocyte-like cells which, however, displays limited biotransformation and a tendency to transform after 20 passages. The new HepaRG-CAR cell line overexpressing constitutive androstane receptor (CAR, NR1I3), a regulator of detoxification and energy metabolism outperforms the parental HepaRG cell line in various liver functions. To further characterize this cell line and assess its stability we compared HepaRG-CAR with HepaRG cells at different passages for their expression profile, ammonia and lactate metabolism, bile acid and reactive oxygen species (ROS) production. Transcriptomic profiling of HepaRG-CAR vs. HepaRG early-passage revealed downregulation of hypoxia, glycolysis and proliferation and upregulation of oxidative phosphorylation genesets. In addition CAR overexpression downregulated the mTORC1 signaling pathway, which, as mediator of proliferation and metabolic reprogramming, may play an important role in the establishment of the HepaRG-CAR phenotype. The ammonia and lactate metabolism and bile acid production of HepaRG-CAR cells was stable for 10 additional passages compared to HepaRG cells. Interestingly, bile acid production was 4.5-fold higher in HepaRG-CAR vs. HepaRG cells, whereas lactate and ROS production were 2.7- and 2.0-fold lower, respectively. Principal component analysis showed clustering of HepaRG-CAR (early- and late-passage) and HepaRG early-passage and not with HepaRG late-passage indicating that passaging exerted larger effect on the transcriptional profile of HepaRG than HepaRG-CAR cells. In conclusion, overexpression of CAR in HepaRG cells improves their bile acid production, mitochondrial energy metabolism, and stability, with the latter possibly due to reduced ROS production, resulting in an optimized source of human hepatocytes.
WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury
Authors: Yu Zhuang , Wang Tingting , Zhang Liming , Yang Xiaohu , Li Quan , Ding Xibing 
Published: March 2020

Abstract
Injurious mechanical ventilation has been shown to directly affect pulmonary and systemic immune responses. How these responses propagate or attenuate remains unknown. The goal of this study was to further determine whether toll-like receptor (TLR) 4 and WNT1-inducible signaling pathway protein 1 (WISP1) could contribute to injurious mechanical ventilation, especially focusing on the role of macrophages during experimental ventilator-induced lung injury. A prospective, randomized, and controlled animal study was designed, and male, wild-type (WT) C57BL/6 mice, TLR4 knockout (TLR4−/−), and lyzTLR4 knockout (lyzTLR4−/−) mice aging 8~12 weeks were used. Animals were anesthetized and randomized to spontaneous breathing (SB) group or to high tidal volume (VT, 20 ml/kg) mechanical ventilation (HTV) group. Histological evaluation, alveolar–capillary permeability of Evan’s blue albumin (EBA), WISP1 protein levels, macrophage inflammatory protein-2 (MIP-2), and interleukin-6 (IL-6) in plasma and bronchoalveolar lavage fluid (BALF) concentrations were analyzed. HTV group was associated with a significant increase of WISP1 and EBA ratio in C57BL/6 mice, a significant decrease of WISP1 protein levels, and a significant decrease of IL-6, MIP-2 in plasma, and BALF concentrations of pro-inflammatory cytokines in TLR4−/− and lyzTLR4−/− knockout mice. In TLR4−/− mice and lyzTLR4−/− mice, there were also significant differences between SB group and HTV group in terms of H&E score and EBA ratio and level of pro-inflammation cytokines. The entire TLR4-targeted mice could further improve various inflammatory changes and damages when compared with lyzTLR4-targeted mice. What is more, TLR4−/− mice and lyzTLR4−/− mice reacted differently to rWISP1 and/or BMMC treated. TLR4−/− mice had no response to rWISP1, while lyzTLR4−/− mice still showed drastic response to both treatments. TLR4 and WISP1, especially the former one, on macrophages could contribute to releasing of pro-inflammatory cytokines during ventilator-induced lung injury. Injurious mechanical ventilation may result in an immune response which is similar to that of infection.
Development of new SNPs loci on Quercus robur and Quercus petraea for genetic studies covering the whole species’ distribution range
Authors: Blanc-Jolivet Celine , Bakhtina Svetlana , Yanbaev Ruslan , Yanbaev Yulai , Mader Malte , Guichoux Erwan , Degen Bernd 
Published: March 2020

AbstractWe used double digest restriction site associated DNA sequencing (ddRAD) to develop new geographically informative nuclear SNP loci in Quercus robur and Quercus petraea. Genotypes derived from sequence data of 95 individuals covering the distribution range of the species were analysed to select geographically informative and polymorphic loci within Russia and Germany. We successfully screened a selected set of 119 loci on a MassARRAY® iPLEX™ platform on 190 individuals from 19 locations in Russia. The newly developed loci will be useful for genetic studies over the whole distribution range of both species.
Experimental investigation on bed shear stress distribution in the roughened compound channel
Authors: Abbaspour Akram 
Published: March 2020

AbstractThe roughness in the floodplains in a compound canal and its impact on hydraulic parameters such as the shear stress and their estimation are one of the problems that have attracted the attention of engineers. In this research, the aim is to investigate the effect of artificial on the floodplain of the compound channel on hydraulic parameters. In experiments, slope of channel bed was 0.0015 and three different discharges have been used. The four types of rigid roughness were used to investigate the effect of these parameters. These roughness elements were arranged with zigzag state with two distances of 4 k and 8 k (k is the height of roughness) in the floodplain. A Preston tube with an external diameter of 3 mm that equipped with dynamic pressure sensors was used to compute the shear stress. The Patel calibration curve was used in order to convert the difference between the static and dynamic pressure measured by the Preston tube to the shear stress values. The results showed that for the zigzag arrangement with the density of 4 k, the shear stress is reduced due to the high roughness density and the greater roughened area. In a rough bed, the shear stress in floodplain was significantly higher than smooth bed, and the stress distribution is such that it has descending trend from the main channel toward the wall of the floodplain. The shear stress increase for roughness with a spacing of 8 k is 22–36% higher than the similar hydraulic condition in a smooth bed and the shear stress for condition with the presence of a cylinder with D = 3 cm and roughness spacing of 8 k was 14–18% higher than the shear stress of bed without a cylinder and the same roughness density. The shear stress for condition of the presence of a cylinder with D = 6 cm and roughness spacing of 4 k is 24–30% more than the roughened plain with distances of 4 k.
Evaluation of morphometric parameters and hypsometric curve of Arkavathy river basin using RS and GIS techniques
Authors: Harsha J. , Ravikumar A. S. , Shivakumar B. L. 
Published: March 2020

AbstractWater availability and water scarcity in a river basin are influenced by the geomorphological processes occurring within a river basin. Therefore, quantitative evaluation of the river basin shape provides a crucial lead in assessment of the impact of geomorphological processes on the hydrology of the basin. Arkavathy river basin has been selected for the present study. The basin with an annual average rainfall of 874.87 mm is a persistent water scarce basin located in Cauvery river basin in south India. The basin has been subjected to rapid urbanization due to which there is an increased water demand over a period of time. Hence, to tackle the growing water scarcity and reoccurrence of droughts in the basin, an attempt has been made in the present study to investigate and understand the basin morphometry and derivation of hypsometric curve of Arkavathy river basin using remote sensing (RS) and geographic information system (GIS) techniques. Quantitative evaluation of basin morphometry has been made, and the impact of basin morphometry on the peak runoff and flooding in the basin has been assessed. The basin hypsometric curve has aided in assessment of the erosion status of the basin and its impact on the risk of sedimentation on water bodies. The morphometric parameters and hypsometric curve are then analysed to investigate the potential impact of the basin morphometry on the water availability and water scarcity afflicting the basin.
Productivity, competition and bank restructuring process
Authors: Llorens Vanesa , Martín-Oliver Alfredo , Salas-Fumas Vicente 
Published: March 2020

AbstractThis paper analyzes how differences in productivity across banks and the evolution of industry productivity over time might determine the intermediation costs and the restructuring process of the banking industry in the Great Recession. With data of Spanish banks, we find that less productive banks are more likely to exit than more productive banks, and that surviving banks acquire target banks in order to expand their branch network in local markets where they are underrepresented. Competition among banks contributes to the translation of industry productivity growth into lower interest rates of loans. Nonetheless, we find that the industry profit margin in loans increases during the period because of the modest industry productivity growth and the lower intensity of competition from branch closing.
Artificial Erythrina Alkaloids from Three Erythrina Plants, E. variegata, E. crista-galli and E. arborescens
Authors: Zhang Bing-Jie , Wu Jing , Bao Mei-Fen , Wang Fang , Cai Xiang-Hai 
Published: March 2020

AbstractFourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata, E. crista-galli and E. arborescens (Fabaceae). The structures of these alkaloids were determined by spectroscopic analyses. Their possible formations were proposed. All isolated compounds showed no cytotoxicity and hypoglycemic activity at cell screening bioassay.
Directing Foreign Investments to Eastern Germany: Swiss Engagements after (and before) 1989
Authors: Allen Keith R. 
Published: March 2020

AbstractThis contribution explains how a specific constellation of Swiss consulting experts, financial advisors, and diplomats became involved in the economic restructuring of eastern Germany after November 1989. Swiss engagements reveal that capital did not merely “flow” across unifying Germany's borders, as economists’ definitions of foreign direct investment suggest. Rather, facilitators within and especially beyond Germany actively promoted investments. Business involving foreigners was often grounded in socialist-era trade activities that united profit seekers from East and West Germany, Switzerland, and other nations. As foreign engagements in unifying Germany's economy illustrate, mediators mattered. Pasts persisted. Debt and investment were intertwined. The course of public divesture and state-sponsored private investment in post-Wall Germany suggests future scholars pay closer attention to individuals and entities engaged in exchanging market information, not so much within individual nations as between them.
A Critical Analysis of the Legal and Regulatory Principles for the Declaration and Payment of Company Dividends in Nigeria
Authors: Akaayar Simon Viashima 
Published: March 2020

AbstractIn Nigeria, corporate law and practice are still evolving. Consequently, there is scant literature on some major aspects of corporate law. The focus of this study is on one such area covering dividends and other forms of corporate distribution. In addition to the lack of constructive legal literature on company dividends and other forms of corporate distribution in Nigeria, most of Nigeria's corporate participants and policymakers are still largely uninformed of the fundamental rules and principles on company dividends. Motivated by the foregoing, this research critically examines the theoretical rationale and extant legal principles on company dividends. Its main objectives are to close the gap in the literature and to provoke scholarly discourse that may further enrich policy reform measures in the area of company dividends in Nigeria.
Marine geological investigation of Edward VIII Gulf, Kemp Coast, East Antarctica
Authors: Dove Isabel A. , Leventer Amy , Metcalf Meredith J. , Brachfeld Stefanie A. , Dunbar Robert B. , Manley Patricia , Shevenell Amelia E. , Murray Richard W. , Hommeyer Matthew , Kryc Kelly A. , McLenaghan Natalie , Taylor Fiona , Huber Bruce A. 
Published: March 2020

AbstractA physical oceanographic, geophysical and marine geological survey of Edward VIII Gulf, Kemp Coast, collected data from conductivity–temperature–depth casts, multi-beam bathymetric swath mapping and 3.5 kHz sub-bottom surveying. Modified circumpolar deep water (mCDW) is observed in Edward VIII Gulf, as well as notable bathymetric features including mega-scale glacial lineations and a 1750 m-deep trough. Sedimentological, geochemical, rock-magnetic and micropalaeontological analysis of two kasten cores document regional palaeoclimate and palaeo-oceanographic conditions over the past 8000 years, with a warm period occurring fromc.8 to 4 ka and a shift to cooler conditions beginning atc.4 ka and persisting until at least 0.9 ka. Sediment packages > 40 m thick within deep troughs in Edward VIII Gulf present potential targets for higher-resolution Holocene and deglacial climate studies. Despite the presence of mCDW on the shelf, inland bed topography consisting of highland terrain suggests the likelihood of relative stability of this sector of the East Antarctic Ice Sheet.
Disaster Planning for Homeless Populations: Analysis and Recommendations for Communities
Authors: Morris Stephen C. 
Published: March 2020

AbstractHomelessness is a growing problem, with perhaps greater than a 150 million homeless people globally. The global community has prioritized the problem, as eradicating homelessness is one of the United Nation’s sustainability goals of 2030. Homelessness is a variable entity with individual, population, cultural, and regional characteristics complicating emergency preparedness. Overall, there are many factors that make homeless individuals and populations more vulnerable to disasters. These include, but are not limited to: shelter concerns, transportation, acute and chronic financial and material resource constraints, mental and physical health concerns, violence, and substance abuse. As such, homeless population classification as a special or vulnerable population with regard to disaster planning is well-accepted. Much work has been done regarding best practices of accounting for and accommodating special populations in all aspects of disaster management. Utilizing what is understood of homeless populations and emergency management for special populations, a review of disaster planning with recommendations for communities was conducted. Much of the literature on this subject generates from urban homeless in the United States, but it is assumed that some lessons learned and guidance will be translatable to other communities and settings.
Unsupervised modeling anomaly detection in discussion forums posts using global vectors for text representation
Authors: Cichosz Paweł 
Published: March 2020

AbstractAnomaly detection can be seen as an unsupervised learning task in which a predictive model created on historical data is used to detect outlying instances in new data. This work addresses possibly promising but relatively uncommon application of anomaly detection to text data. Two English-language and one Polish-language Internet discussion forums devoted to psychoactive substances received from home-grown plants, such as hashish or marijuana, serve as text sources that are both realistic and possibly interesting on their own, due to potential associations with drug-related crime. The utility of two different vector text representations is examined: the simple bag of words representation and a more refined Global Vectors (GloVe) representation, which is an example of the increasingly popular word embedding approach. They are both combined with two unsupervised anomaly detection methods, based on one-class support vector machines (SVM) and based on dissimilarity to k-medoids clusters. The GloVe representation is found definitely more useful for anomaly detection, permitting better detection quality and ameliorating the curse of dimensionality issues with text clustering. The cluster dissimilarity approach combined with this representation outperforms one-class SVM with respect to detection quality and appears a more promising approach to anomaly detection in text data.