bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blastic plasmacytoid dendritic cell neoplasm in a young female: Rare and challenging
Authors: Modak Ketan , Garg Jeevan Kumar , Mishra Deepak Kumar , Radhakrishnan Vivek S 
Published: October 2020

AbstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic malignancy with an aggressive behavior, seen commonly in the elderly age group and usually involves the skin. Evaluation, diagnosis, and treatment pose unique challenges with poor outcomes. We report a case of an 18-year-old female who presented with lymphadenopathy and bicytopenia. The diagnosis of BPDCN was an initial challenge. She thereafter received intensive chemotherapy followed by an allogenic partially mismatched sibling donor hematopoietic cell transplantation, only to relapse in a few months. Beginning from the diagnosis, the management of this rare disorder and its relapse until her last followup provided several learning opportunities.
Non-Hodgkin Lymphoma Relapse Presenting as Isolated Neurolymphomatosis of the Brachial Plexus - A Case Report
Authors: Parashar Yatendra , Hasan Faheema , Bishnu Arijit , Kashyap Rajesh 
Published: October 2020

AbstractNeurolymphomatosis is a rare manifestation of non-Hodgkin's lymphoma (NHL) and is characterized by infiltration of the nerves by neoplastic lymphoid cells and is seen in up to 0.2% of all NHL cases. Diagnosing this syndrome is quite a challenge to the hematologists given the vague symptoms and signs and the low incidence. Newer imaging modalities such as positron emission tomography–computed tomography and magnetic resonance imaging have enabled early diagnosis with a sensitivity reaching up to 100%. Despite a variety of therapies reported in the literature for the treatment, the prognosis is very poor. We report a 46-year-old male diagnosed to have NHL–diffuse large B-cell lymphoma and treated with rituximab, cyclophosphamide, vincristine, and prednisolone (R-CHOP) therapy who presented with left brachial plexus neurolymphomatosis as the initial feature of disease relapse.
A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement
Authors: Moothedath Abdul Wajid , Sahoo Debasish , Seth Rachna , Meena Jagdish Prasad , Gupta Aditya Kumar 
Published: October 2020

AbstractEosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential risk of end-organ damage associated with it. Given the broad differential diagnoses of eosinophilia, it is essential to have a systematic approach to the evaluation of unexplained eosinophilia in children. Here, we discuss the case of a 2-year-old child who presented with very high eosinophil counts. A systematic workup of the case helped us in arriving at a rare diagnosis of platelet-derived growth factor receptor-beta (PDGFRB)-rearranged clonal eosinophilia. Identification of such an entity is important as it has therapeutic implications, and early recognition helps in preventing associated end-organ damage by instituting appropriate therapy. Such cases of eosinophilia associated with platelet-derived growth factor receptor-alpha and PDGFRB rearrangement respond dramatically to imatinib.
Oral mucositis with abiraterone acetate: A therapeutic dilemma
Authors: Valame Shaunak , Chandra G Sharat , Panda Dipanjan , Sharma Atul 
Published: October 2020

AbstractMucositis is a common complication of cancer treatment. Mucositis has varied etiology. Here, we describe a case of 71-year-old male with metastatic castrate-resistant carcinoma prostate who developed mucositis with the use of targeted therapy, and this particular scenario led to the therapeutic dilemma.
Imidazole and carbazole derivatives as potential anticancer agents: molecular docking studies and cytotoxic activity evaluation
Authors: Taheri B. , Taghavi M. , Zarei M. , Chamkouri N. , Mojaddami A. 
Published: October 2020

Carbazoles and imidazole represent two important classes of heterocycles which exhibit diverse biological activities such as antitumor properties. In this study, imidazole (C1-C3) and carbazole (C4 and C5) derivatives were evaluated for their cytotoxic activity against three human cancer cell lines namely, MCF7 (human breast cancer), HT29 (human colon cancer), and HeLa (human cervical cancer). Carbazole derivatives (C4 and C5) with IC50 < 10 µM showed greater cytotoxic effect than imidazole derivatives (C1-C3). Furthermore, all compounds exhibited better anticancer activity against MCF-7 than other two cell lines (HT-29, HeLa) and compound C4 was the most potent compound with the IC50 values of 2.5, 5.4 and 4.0 µM, against MCF-7, Hela and HT-29 cell lines, respectively. Physicochemical properties of compounds were calculated and their correlation with the IC50 values on MCF-7 cell line investigated. Surface area and polarizability of compounds showed good correlation by R2 = 0.8396 and R2 = 0.834, respectively. Docking studies of these compounds were also performed on the DNA as proposed target to comprehend their binding interactions and binding energies. The docking energy of compounds ranged from - 11.32 to -13.48 kcal/mol. Compound C3 with energy of -13.48 kcal/mol had the highest docking energy. Docking results indicated that these compounds (C1-C5) had strong affinity in binding to the DNA.

KEY WORDS: Imidazole, Carbazole, Molecular docking, Cancer, MTT assay

Bull. Chem. Soc. Ethiop. 2020, 34(2), 377-384
DOI: https://dx.doi.org/10.4314/bcse.v34i2.14
Production and characterization of biodiesel and glycerine pellet from macroalgae strain: Cladophora glomerata
Authors: Firemichael D. , Hussen A. , Abebe W. 
Published: October 2020

Biodiesel was prepared by extracting oil from Cladophora glomerata green algae followed by transesterification of the oil using NaOH as a catalyst. The algae Oil extraction was carried out using two different techniques (Soxhlet and refluxing) and similar oil yield was obtained (23-24%). The resulting biodiesel showed desirable physical and chemical properties. Specific gravity, acid value, iodine value, ash content and calorific value of the algae biodiesel were within the specification of American Society for Testing and Materials (ASTM) and European Standards (EN). The analysis of fatty acid methyl ester composition revealed, 63, 27 and 10% for 9-octadecodenoic, hexadeconic and octadeconoic acid methyl ester, respectively. From the production line, two waste streams (glycerol and residual biomass) were combined to form a glycerine pellet. The measured energy content of the glycerine pellet was found to be comparable with firewood. Therefore, C. glomerata could potentially be utilized for the production of both biodiesel and glycerine pellet with no net waste in the transesterification process.

KEY WORDS: Algae oil, Biodiesel, Transesterification, Glycerine pellet, Macroalgae, Cladophora glomerata

Bull. Chem. Soc. Ethiop. 2020, 34(2), 249-258
DOI: https://dx.doi.org/10.4314/bcse.v34i2.4
Educação do campo e sua trajetória no ensino em Pau dos Ferros – RN
Authors: Maria de Bem Geralda , Nilton Moreira da Silva Cícero 
Published: October 2020

Considerando que os sujeitos precisam pensar o mundo a partir do lugar de onde vivem, e sendo o campo seu lugar de fala, é nele que eles devem ser educados como sujeitos de história, vinculados às lutas sociais. Evidentemente que a identidade das escolas do campo tem como pressuposto questões inerentes à sua realidade, levando em consideração os saberes próprios dos educandos, bem como sua forma de pensar o mundo e saber escutar o outro diante das suas particularidades. Este artigo tem como objetivo analisar a trajetória do ensino nas escolas com turmas multianos situadas no campo pauferrense (RN). Adotamos como abordagem metodológica, a pesquisa bibliográfica, estudando os autores: Caldart (2011), Arroyo, Caldart e Molina (2011,) Vendramini (2007), Fernandes (1999), Souza (2012), bem como as Diretrizes Operacionais para a Educação Básica nas escolas do Campo, dentre outras referências que abordam a temática em estudo. Em síntese, este trabalho nos evidenciou a necessidade de aprofundarmos nossa reflexão acerca da Educação do Campo e os aspectos que permeiam o ensino nas escolas com turmas multianos, visto que o campo é um espaço vivo. É nele que os sujeitos se mobilizam, produzindo uma dinâmica social e cultural, tendo a educação e a escola como foco de debate dessa dinâmica educativa dos diversos povos do campo.

Palavras-chave: Educação do Campo. Turmas multianos. Ensino.
Educação do campo: uma história de luta e resistência
Authors: Santos Silvanete Pereira dos 
Published: October 2020

Resumo: Esse artigo objetiva apresentar uma breve discussão sobre a historicidade da educação do campo no Brasil. Ele acrescenta a esse histórico três últimos grandes eventos no campo da pedagogia da alternância e da educação do campo de modo geral. Traz as considerações do segundo Encontro Nacional de Educadores e Educadoras da Reforma Agrária (II ENERA), do aniversário dos 50 anos do Movimento Educacional Proporcional do Espírito Santo (MEPES), precursor da pedagogia da alternância no Brasil, e os apontamentos do Seminário Internacional dos 50 anos da Pedagogia da Alternância no Brasil.

Palavras-chave: Educação do Campo. Pedagogia da Alternância. Movimentos sociais do Campo.
EL DELITO DE NOMBRAMIENTO ILEGAL PARA CARGO PÚBLICO EN EL DISTRITO JUDICIAL DE PUNO
Authors: Castro Mendoza Karen Vanessa 
Published: October 2020

En el presente artículo, se abordarán cuestiones relacionadas a la interpretación y aplicación de los alcances del delito de nombramiento ilegal para cargo público, en el distrito judicial de Puno, en razón a que dicho ilícito, usualmente no es aplicado para el supuesto de una “designación” para cargo público; sino que se aplica específicamente para casos en los que se contrató a una persona bajo la modalidad de plazo indeterminado.
Asimismo, se tiene que dentro de los elementos objetivos de dicho injusto penal, también existe un gran debate, en relación a la aplicación del término “requisitos legales”, creyéndose que dicho extremo solo abarcaría una norma con rango de ley, excluyendo a resoluciones administrativas que se dan dentro de una determinada institución pública, las mismas que fijan los requisitos a cumplir para un determinado perfil o puesto de trabajo, lo que en muchos casos, ha ocasionado que las personas procesadas bajo los alcances de dicho tipo penal, obtengan condenas, cuando en otros distritos judiciales, son absueltos por hechos similares, de ahí, se sostiene que la falta de claridad en el contenido del citado delito, conlleva a una mala interpretación y aplicación de esta figura por parte de los operadores de justicia, pues no existe un criterio uniforme al respecto.
The Libyans Attitudes towards Democratic Transition
Authors: Kashiem Prof. Dr. Mustafa Abdalla 
Published: October 2020

Libya has witnessed a democratic transition process since the early months of 17th February Revolution, 2011.However, aftereight years, there is still a gap in the literature about this topic. Thus, this study aims to fulfil a part of this gap by describing and analyzing the Libyan attitudes towards the democratic the transition process in Libya post Kaddafi era during the years, 2012-2014. Currently, the Libyans view themselves as participants in the democratic process that Libya is enjoying since August 2011, when the declaration of the liberating of Libyan was announced by the President ofthe Interim Transitional National Council “ITNC” in Benghazi. The findings of this study demonstrate that the Libyans are no longer view themselves as belonging to parochial or subjective political cultures; and therefore, the rate of registration on the 7thof July 2012 election reached 93%, whereas the ratio of the actual voting reached 65% of the total eligible voters. The negative attitudes towards Kaddafi’s regime have changed into positive patterns after the victory of 7thFebruary Revolution. These positive attitudes towards participation culture are spilled over towards the new political system as well as its internal and external policies. Nevertheless, negative attitudes towards issues that threat the national identity have been reported as the majority of the participants rejected federalism as a political system for the new Libya. The findings also indicate that issues related to Amazigh language, liberal democracy and forgiveness with Kaddafi’s supporters before the interim- justice takes place were also rejected by a large portion of the sample.
Keywords: ITNC, NPC, the Interim Constitutional Declaration, system attitudes, process attitudes, policy attitudes.
La calidad de las publicaciones científicas pasa por la ética
Authors: Mercado Sandy Daniel 
Published: October 2020

Sr. Editor:
El objeto de esta carta es llamar la atención respecto a problemas éticos que ocurren en relación a las publicaciones científicas y que afectan su prestigio, calidad y reconocimiento. El profesional que acude a una revista médica con la expectativa de encontrar información válida, para con ella mejorar el manejo de problemas de salud de las personas, debe tener garantías suficientes de que la información ofrecida sea veraz y confiable. Ahí descansa la razón de ser de las revistas médicas y la utilidad que prestan.
Primer intercambio de investigación en México
Authors: Cossio Andia Eddy 
Published: October 2020

La investigación científica y el desarrollo tecnológico constituyen una parte fundamental del progreso de los países, y mas aun en la carrera de medicina1.
En los últimos años ha surgido un interés creciente por realizar investigación en medicina en todos los niveles de educación2.
Tengo la dicha de haber sido el primer estudiante de medicina de Bolivia en realizar el intercambio de investigación con el programa Standing Committee Research Exchanges (SCORE) de la International Federation of Medical Students Associations (IFMSA).
Mi intercambio duro un mes y lo realice en el departamento de fisiología cardiovascular experimental de la Universidad Autónoma de Nuevo León (UANL), Monterrey - México.
Investigación y comunicación de resultados
Authors: Illanes Velarde Daniel E. 
Published: October 2020

El ARCUSUR (Sistema de Acreditación Regional de Carreras Universitarias de los Estados Partes del MERCOSUR y Estados Asociados), actual mecanismo permanente de acreditación regional, es el que garantiza públicamente el nivel académico y científico de los recursos, según criterios regionales elaborados por la Red de Agencias Nacionales de Acreditación. Respetando las legislaciones nacionales y la participación voluntaria de las instituciones de educación realiza procesos de acreditación en forma continua en base a convocatorias periódicas1.
La Carrera de Medicina “Dr., Aurelio Meleán” de la Universidad Mayor de San Simón ha recibido su 4ta Acreditación consecutiva por parte de éste organismo, por el periodo de 2019 al 2025. Este mecanismo de acreditación sudamericano, establece estándares de evaluación para el componente de Investigación Científica en las escuelas de medicina, velando por su desarrollo, integración con los procesos de enseñanza y aprendizaje en la formación médica, la relación de esos procesos de investigación con las necesidades y prioridades de salud de la población y la forma de comunicación y/o uso de los resultados de las investigaciones en la comunidad académica docente estudiantil.
El Parc del Colors. Viaje – Viatge 20(20)
Authors: Gomez Raby Alfonso Javier 
Published: October 2020

El Parque de los Colores de Mollet del Vallés, inaugurado el año 2001 como homenaje póstumo al arquitecto Enric Miralles, es una obra de reactivación del espacio púbico, instalada en el centro de su biografía. Intentando reconstruir una versión de la historia de esta obra, e imposibilitado de volver a visitar el Parque, inicio un viaje por medio de conversaciones a distancia con personas claves en la generación de este proyecto, quienes me han permitido enfocar la mirada en la continuidad de los trayectos, en el momento de las preguntas inconclusas procedentes de otros finales abiertos. Con estas personas Miralles hizo estos caminos, los cuales él decía que no sabía imaginar, construía las ideas por medio del dibujo, de la suma de capas e intérpretes, colaboradores sucesivos, del mismo problema. A 28 años de la llegada del encargo al estudio en Carrer d'Avinyó, y a 20 años de su partida, se siguen imaginando versiones del mismo proyecto y constatando que este lugar nunca ha dejado de transformarse, Enric Miralles lo sabía.
Desinformación y erosión de la credibilidad periodística en el contexto de las noticias falsas. Estudio de caso
Authors: Del Hoyo Hurtado Mercedes , García-Galera María del Carmen , Blanco-Alfonso Ignacio 
Published: October 2020

El presente artículo propone un análisis de la correlación entre la pérdida de credibilidad de los medios, los desórdenes informativos y la opacidad de los procedimientos de producción de noticias. Para ello, se trae aquí el estudio de caso de un reportaje publicado por el periódico El Mundo en su suplemento Crónica, con el fin de analizar qué formas adopta la desinformación en la prensa de referencia y hasta qué punto puede estar afectándola más allá de lo que acontece en las redes sociales. El recurso a la invención o la suplantación de fuentes fidedignas en los bulos que circulan por la red dejan aquí paso, entre otros, a la mezcla indiscriminada de datos falsos con datos verdaderos, y a las referencias vagas sobre fuentes cuya identidad es imposible comprobar.
El largo camino para la equidad de género en la prensa escrita mexicana
Authors: Treviño Elizondo Francisco Antonio , Quiroga Garza Angélica , Matamoros Juan Antonio , Willis Sánchez Byrd 
Published: October 2020

Esta investigación analizó el grado de equidad y estereotipos de género que se presentan en uno de los periódicos más longevos e importantes de México: El Norte de Grupo Reforma, considerando el género de los autores de las notas, de las fuentes citadas, pero principalmente de sus protagonistas (tomando en cuenta el contenido de los titulares, fotografías, secciones en que aparecen, sus ocupaciones, y si se les trata o no como víctimas). Se comprobó que a nivel local se reproducen actualmente los mismos resultados que se han encontrado históricamente a nivel mundial: Los hombres está sobrerrepresentado en todos los rubros: artículos escritos, protagonismo, testimonios, opinión experta, rol de víctimas y fotografías; además aparecen principalmente en notas sobre política y deporte, mientras las mujeres en notas del mundo del espectáculo. A pesar de que la investigación reafirma lo ya encontrado en otras latitudes, se discuten algunas importantes señales de cambio.
Proceso de adaptación del Inventario de la relación de ayuda de G.T. Barrett-Lennard
Authors: Celis H. Alejandro 
Published: October 2020

la presente investigación expone la realización de las etapas iniciales de la adaptación al español del Inventario de la relación de ayuda de G.T. Barrett-Lennard, en su versión OS-M-64. Se exponen diversas consideraciones respecto a la importancia del puntos de vista del "receptor" de la relación, respecto a la utilidad del cuestionario y respecto a la metodología empleada en su adaptación. se discuten dificultades metodológicas halladas en la investigación y se entrega una versión completa del inventario y de la forma de utilizarlo.
Pages of the life of M.V. Timofeev-Ressovsky in the material historical sources
Authors: Blume Ya. B. , Barshteyn Yu. V. 
Published: October 2020

Aim. To investigate and to enter into scientific circulation material historical sources related to the biography of M.V. Timofeev-ResSovsky. Methods. The paper used both general scientific (historical, logical) and special (subject-chronological, retrospective) methods. Results and discussion. The role of Kyiv in shaping the future scientific vocation of M.V. Timofeev-Ressovsky, the work of a scientist in Germany and the reasons why he did not return to the USSR in the late 1930s, outlines the facts of Timofeev-Ressovsky life after the Second World War. The scientific activity of scientist has been briefly analyzed. Conclusions. The analysis of material historical sources made it possible to investigate and bring into scientific circulation the objects of phaleristics, numismatics (medallic art), philately and a rather rare object of collecting – telephone cards of the Russian Empire, the USSR, Russia, the former GDR and Germany, to tell about some pages of the biography of M.V. Timofeev-Ressovsky.
Keywords: M.V. Timofeev-Ressovsky, history of biology, phaleristics, numismatics, philately, telephone card.
Evaluation of genetic diversity of honey bee in Ukraine analyzed by the SSR-markers
Authors: Hryhorchuk D. I. , Rabokon A. M. , PostovoitovA A. S. , Pirko N. M. , Pirko Ya. V. , Blume Ya. B. 
Published: October 2020

Aim. The aim of the work was to analyze current genetic structure of honey bee populations in Ukraine that belong to different subspecies: A. meliffera meliffera, A. meliffera carnica, A. meliffera macedonica using microsatellite markers. Methods. SSR-analysis was used for evaluation of the honey bee polymorphism. Amplified fragments were fractionated by electrophoresis in non-denaturing polyacrylamide gel. DNA bands were detected using silver nitrate staining. Results. The analysis of the sample of honey bees (workers and male-bees) collected from different regions of Ukraine was performed by using two SSR-markers (Ac011 and A007). In this sample reasonably high polymorphism was observed, especially for the SSR-marker A007. Conclusions. It was estimated that SSR-analysis method can be applied in molecular-genetic analysis of honey bees for evaluation of genetic diversity and cross-subspecies hybridization.
Keywords: microsatellite markers, Apis meliffera, PIC (Polymorphism Information Content).
Analysis of the role of kynurenine metabolism in drosophila viability control at the high sugar diet influence
Authors: Navrotskaya V. V. , Sapota Yu. Yu. 
Published: October 2020

Aim. To analyze viability and life span of drosophila at genetic and pharmacological inhibition of tryptophan-kynurenine metabolism, when cultivating on the standard nutritive medium and at a high sugar diet. Methods. Wild type stock and the stock with vermilion mutation have been used. Viability (number of individuals, mortality at the pupal stage) and median life span of imagoes have been determined. Results. High sugar diet has been found to negatively affect the viability of drosophila, leading to increased mortality at the pupal stage and decrease of males’ life span; wild-type stock is less resistant to the influence of such diet as compared with mutant stock. Berberine (an inhibitor of tryptophan dioxygenase) when added to the high sugar nutritive medium reduces the negative effect of a high sugar diet on life span of the wild-type stock: males’ life span reaches control values and in females life span is even more than in the control. Conclusions. Decrease of kynurenines content in the flies organisms (both at the genetic and pharmacological inhibition of tryptophan-kynurenine metabolism) may attenuate negative influence of the high sugar diet.
Keywords: drosophila, viability, life span, kynurenine pathway of tryptophan metabolism, high sugar diet.