bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro and In Silico Anti‐Inflammatory Activities of Crude Extract and Phloroglucinol Derivatives from Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)
Authors: Tchamgoue Joseph , Pechangou Sylvain N. , Issahaku Abdul R. , Ngandjui Yvan Anderson T. , Wilhelm Anke , Kamto Eutrophe L‐D. , Moundipa Paul F. , Kouam Simeon F. 
Published: December 2024

AbstractNumerous anti‐inflammatory agents are used nowadays to relieve daily aches and pain. However, their severe side effects often limit their therapeutic use. In this study, we investigate the anti‐inflammatory activity of the crude leaves extract of Mallotus oppositifolius and five of its phloroglucinol derivatives (MO1–MO5). From spectroscopic and spectrometric analysis, the compounds were identified as mallotojaponin B (MO1), mallotojaponin D (MO2), acronyculatin U (MO3), acronyculatin T (MO4), and mallotojaponin C (MO5). A primary macrophage culture activated by Saccharomyces cereviseae (SC) was used to evaluate the anti‐inflammatory activity of the crude extract and isolated compounds which were found to be nontoxic to primary macrophages at concentrations ranging from 0.1–50 µg/mL. In addition, the tested samples inhibited the 5‐lipoxygenase activity, nitric oxide (NO), and tumor necrosis factor alpha (TNF‐α) production by viable primary mouse macrophages in a concentration‐dependent manner with MO1 and MO3 exhibiting the highest in vitro anti‐inflammatory activities. Moreover, in silico studies were performed with the isolated compounds to evaluate their binding capacities/scores against the main enzymes involved in inflammation mediation in human cells. The compounds showed good binding affinities to critical anti‐inflammation targets particularly mallotojaponin C (MO5) (−44.55 Kcal/mol) and acronyculatin T (MO4) (−41.44 Kcal/mol) which showed the highest affinity for 5‐lipoxygenase.
Highly Dispersed Palladium Nanoparticles on Carbon Doping with Nitrogen Derived from MOFs for 4‐Nitrophenol Hydrogenation
Authors: Wang Rui , Yuan Jiali , Zhang Huan , Liu Xiang , He Jiani , Zhu Lihua 
Published: December 2024

AbstractA series of the Pd/NC samples with various Pd loadings (0.11%, 0.48%, and 2.52%) are prepared via sodium borohydride (NaBH4) reduction method and carbon doping with nitrogen (NC) is acquired by the pyrolysis of ZIF‐8. The samples are characterized by XRD, BET, SEM, TEM, HRTEM, STEM‐EDX elemental maps and line‐scanning, XPS, TG, and so forth. It confirms that the Pd nanoparticles (NPs) are successfully coated on the NC. The catalytic behaviors of the samples are evaluated by the hydrogenation of 4‐nitrophenol (4‐NP), the 2.52%Pd/NC catalyst shows the best catalytic property among as‐obtained catalysts maybe due to the much more Pd(0) species. The 2.52%Pd/NC catalyst exhibits 100% selectivity to 4‐aminophenol (4‐AP) at high conversion of 4‐nitrophenol and 321.8 h−1 turnover frequency (TOF) under mild reaction conditions (3.0 MPa H2, 40 °C, 1 h). Moreover, the catalysts show an excellent stability.
Evolution of Telomerase Inhibitors: A Review on Key Patents from 2015 to 2023
Authors: Dey Rajdeep , Vishwakarma Keerti , Patel Bhumika , Vyas Vivek K. , Bhatt Hardik 
Published: December 2024

AbstractTelomerase (TERT) is a ribonucleoprotein that regulates telomere length and maintains chromosomal integrity. TERT is a widely expressed protein for replicative immortality in most malignant tumours. TERT is a protein produced by cancer cells that prevents telomere shortening by adding telomere sequences beyond the Hayflick limit, allowing them to divide in an uncontrolled manner. Inhibition of the TERT enzyme is a recognised therapy for treating cancer. The basic objective of the review is to collectively represent the current scenario of treating cancer by inhibiting TERT. With a focus on the recently patented TERT inhibitors and clinical trial data released between 2015 and 2023, this review highlights the work relevant to the development of TERT inhibitors. Furthermore, recent advancements in the clinical development of TERT inhibitors, along with prospective new combinations, are also discussed. The use of TERT inhibitors in cancer therapy has been granted with great interest and significant attention by researchers along with a promising outcome in terms of therapeutic value. Several clinical trial applications and their data gave strong evidence of the use of TERT inhibitors for cancer therapy which provided target therapies, vaccine therapies, nucleoside, non‐nucleoside therapies, and so forth with reduced side effects and enhanced potency.
Labyrinthine Wrinkle‐Patterned Fiber Sensors Based on a 3D Stress Complementary Strategy for Machine Learning‐Enabled Medical Monitoring and Action Recognition
Authors: Lv Yongming , Chu Zhenming , Huang Desheng , Fan Xiaoxing , Zhang Wei 
Published: December 2024

AbstractFiber strain sensors show good application potential in the field of wearable smart fabrics and equipment because of their characteristics of easy deformation and weaving. However, the integration of fiber strain sensors with sensitive response, good stretchability, and effective practical application remains a challenge. Herein, this paper proposes a new strategy based on 3D stress complementation through pre‐stretching and swelling processes, and the polydimethylsiloxane (PDMS)/silver nanoparticle (AgNPs)/MXene/carbon nanotubes (CNTs) fiber sensor with the bilayer labyrinthian wrinkles conductive network on the PU fiber surface is fabricated. Benefiting from the wrinkled structure and the synergies of sensitive composite materials, the fiber sensor exhibits good stretchability (>150%), high sensitivity (maximum gauge factor is 57896), ultra‐low detection limit (0.1%), fast response/recovery time (177/188 ms) and good long‐term durability. It can be used as Morse code issuance and recognition to express the patient's symptoms and feelings. Further, the sensor enables comprehensive human movement monitoring and collects data of different characteristics with the assistance of machine learning, different letters/numbers are recognized and predicted with an accuracy of 99.17% and 99.33%. Therefore, this fiber sensor shows potential as a new generation of flexible strain sensors with applications in medical monitoring and human‐computer interaction.
Cascade Design and Facile Fabrication of Cu/Cu2O/CuAl‐Layered Double Hydroxides as Efficient Nitrate Reduction Electrocatalysts
Authors: Bai Yajie , Fang Zhenyuan , Jia Kangkang , Jiang Xianlei , Gao Yiwei , Lin Chenxiao , Ma Denghui , Li Jianming , Bai Hongye , Fan Weiqiang 
Published: December 2024

AbstractNitrate (NO3¯) reduction reaction (NITRR) presents a promising pathway for the production of renewable NH3 while concurrently decontaminating NO3¯ wastewater. However, the multi‐electron transfer sequence and complex reaction network involved in NO3¯ conversion pose significant challenges to achieving high Faradaic efficiency (FE). Herein, this work presents ternary Cu/Cu2O/CuAl‐layered double hydroxides (LDHs) catalysts designed through a cascade approach and synthesized via a straightforward one‐step electrodeposition method. The resulting catalysts demonstrate peak activity at −0.4 V versus RHE, achieving an impressive of 92.0%, which significantly surpasses most reported binary and ternary catalysts. Density functional theory calculations and atomic force microscopy reveal that the Cu/Cu2O/CuAl‐LDHs exploit cascade design by integrating three distinct functions essential for efficient NO3¯ reduction: CuAl‐LDH initiates NO3¯ adsorption, Cu(111) and Cu₂O(111) cooperatively facilitate NO3¯ activation, and Cu(111) promotes NH3 desorption. Durability tests further confirm that both NH3 yield and remain stable after 10 cycles, indicating the excellent stability of the Cu/Cu2O/CuAl‐LDHs catalysts. These findings underscore the critical role of cascade design strategies in enhancing the performance of electrocatalysts for NO3¯ reduction to NH3, providing a transformative approach for sustainable ammonia synthesis.
The Engineering Screen of Photoactive Nanozymes Based on N‐Containing Covalent Organic Frameworks for Antibacterial Application
Authors: Zhao Jianchao , Wang Lijuan , Jia Lingshan , Liu Yahui , Cao Shoupeng , Wen Jia , Li Wei , Yang Kui 
Published: December 2024

AbstractCovalent organic frameworks (COFs) are a class of highly efficient photocatalytic organic semiconductor materials, which have been developed for the design of photoactive nanozymes. Nitrogen (N)‐heterocycles could effectively improve their photocatalytic activity of COFs. However, the systematic exploration of photoactive nanozymes based on N‐containing COFs is still lacking. In this work, a series of N‐containing Schiff‐base linkages of COFs are designed and synthesized to explore high‐performance photoactive nanozymes. In addition, Fe ions are introduced through post‐modification of COFs, which can not only effectively extend the band‐edge absorption of COFs to the red‐light region and thereby broaden its biological applications, but also introduce single site of Fe to enrich the types of free radicals in the catalytic products. The activities of photoactive nanozymes based on N‐containing COFs are systematically studied, and their catalytic mechanisms are uncovered. Interestingly, it is not as commonly recognized that the more content of N, the better for photocatalysis or the construction of photoactive nanozyme. Furthermore, the selected photoactive nanozymes are used for antibacterial applications, which showed good activity against Escherichia coli.
“One‐Pot” Synthesized Phosphorus Corrole‐Based Metal–Organic Frameworks for Synergistic Phototherapy and Chemodynamic Therapy
Authors: Deng Wenbo , Wei Zixiang , Xu Yunhao , Gong Zhichao , Cai Fenglin , Shi Quan , Guo Kai , Jia Meng , Zhao Yanming , Feng Yaqing , Deng Jingyu , Zhang Bao 
Published: December 2024

AbstractAs a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal–organic frameworks (MOFs) that incorporate photosensitive corroles as functional ligands for synergistic phototherapy remains a formidable challenge. Herein, for the first time, the unique phosphorus corrole‐based MOFs Cor(P)‐Hf with (3,18)‐connected gea topology are reported, which are constructed by Cs‐symmetric dicarboxylate 3‐connected linkers, 10‐pentafluorophenyl‐5,15‐di(p‐benzoate)phosphorus corrole (Cor(P)), and the peculiar D3h‐symmetric 18‐connected Hf12‐oxo clusters. Interestingly, six para‐position F substituents of six Cor(P) linkers are found to be coordinated with the apex of the Hf12‐oxo cluster through Hf‐F bonds along the c‐axis direction, which is believed to help stabilize the framework. Furthermore, the mixed corrolic ligand‐based MOFs Cor(P)/Cor(Cu)‐Hf and Cor(P)/Cor(Fe)‐Hf involving Cor(Fe) or Cor(Cu) as the secondary functional linkers are constructed by a simple “one‐pot” solvent‐thermal method, respectively. Remarkably, Cor(P)/Cor(Fe)‐Hf facilitates synergistic phototherapy combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) when activated by an 808 nm laser, as evidenced by in vivo and in vitro experiments. This study demonstrates corrole‐based MOFs Cor(P)‐Hf as a powerful multifunctional nanoplatform for anti‐cancer phototherapy.
Cellulose Acetate Membranes: Antibacterial Strategy and Application—A Review
Authors: Li Fu , An Yaxin , Xue Jinhong , Fu Hui , Wang Hongbo , Cao Puzhi , Zhang Man , Fei Pengfei , Liu Mei , Zhao Fulai 
Published: December 2024

AbstractDeveloping antibacterial and biodegradable cellulose acetate (CA) membrane materials is one of the main challenges in multiple application fields. CA membrane materials are widely used in gas purification, water purification, and biomedical fields due to their environmental friendliness, high chemical and mechanical stability, excellent processability, and low cost. However, antibacterial modification of CA membrane materials to enhance their utilization value in the application process has always been the direction of researchers' efforts. This review focuses on the preparation and application of antibacterial CA and its derivatives membranes, especially the types and introduction methods of antibacterial agents. First, a brief introduction of CA‐based polymer membranes is presented, followed by an overview of the antibacterial agent types and their introduction methods, and antibacterial mechanisms. After that, various membranes prepared using CA‐based polymers as the main matrix or as additives are discussed. Then, specific applications of antibacterial CA‐based membrane materials in water purification, gas purification, biomedical, food packaging, and other fields are outlined.
Unraveling the Synergistic Role of Sm3+ Doped NiFe‐LDH as High‐Performance Electrocatalysts for Improved Anion Exchange Membrane and Water Splitting Applications
Authors: Nagappan Sreenivasan , Gurusamy Hemalatha , Minhas Harpriya , Karmakar Arun , Ravichandran S. , Pathak Biswarup , Kundu Subrata 
Published: December 2024

AbstractEffective first‐row transition metal‐based electrocatalysts are crucial for large‐scale hydrogen energy generation and anion exchange membrane (AEM) devices in water splitting. The present work describes that SmNi0.02Fe‐LDH nanosheets on nickel foam are used as a bifunctional electrocatalyst for water splitting and AEM water electrolyzer study. Tuning the Ni‐to‐Fe ratios in NiFe‐LDH and doping with Sm ions improves the electrical structure and intrinsic activity. SmNi0.02Fe‐LDH has higher oxygen evolution reaction (OER), HER, and TWS activity, achieving 10 mA cm⁻2 current density at lower overpotentials (230 mV, 95 mV, and 1.62 V, respectively). In AEMWE cells, SmNi0.02Fe‐LDH as a cathode and anode pair exhibits outstanding activity (0.9 A cm⁻2 at 2 V) and stability over 120 h. Density Functional Theory (DFT) investigations reveal that the Sm doping in NiFe‐LDH surface enhances its bifunctional activity toward OER and HER. These findings emphasize the potential of non‐noble composites for long‐term water electrolysis in total water splitting and AEMWE applications.
An LC‐MS/MS Method Development and Validation for the Quantification of Abametapir in Plasma Samples
Authors: Sankar Palakollu D. S. , Panigrahi Naresh 
Published: December 2024

ABSTRACTThe major goal of the current research study was to establish a sensitive tandem mass spectrometric method using electrospray ionization and liquid chromatography for quantifying abametapir in biological matrices. An Inertsil ODS chromatographic column with dimensions of 50 × 4.60 mm and 5.0 µm particles size was used to achieve chromatographic elution. Injection volume was set to 10.0 µL. Flow rate and stationary phase oven temperature were retained at 0.70 mL/min and 25.0°C. Isocratic elution was executed with acetonitrile, 0.10% v/v HCOOH, and methanol in a fraction of 20:10:70 (v/v/v) as the mobile phase. On multiple reaction monitoring, precursor‐product ion transitions were monitored at m/z 185.1→106.06 for abametapir and 287.16→269.15 for the abacavir internal standard. The drug's linearity graph had an r2 value of 0.9998 and was rectilinear at concentrations between 2.6 and 104 ng/mL. The inter‐ and intrabatch precision % relative standard deviation values ranged from 2.57 to 4.53. In short, the method that was made has been proven to work and validated as per the regulatory guidelines.
Super‐resolution imaging of urethral vasculature in female pigs: Validation of clinical feasibility and accuracy
Authors: Wang Xia , Hua Chen , Sheng Kai , Xu Zhiming , Zhang Rui , Ying Tao 
Published: December 2024

AbstractThe efficacy and reliability of super‐resolution (SR) imaging for evaluating urethral vasculature (UV) in females remains uncertain. This study evaluates the super ultrasound for grand accuracy and resolution (SUGAR) method, an SR modality, for visualizing UV in female pigs within clinical ultrasound settings, aiming to establish its clinical feasibility and accuracy for potential human application. Female pigs (40–45 kg) were used to investigate UV blood flow dynamics, with data collected via a handheld ultrasound probe at 100 fps. The images were processed using SUGAR to achieve a resolution of <30 µm and validated against computed tomography angiography (CTA) and histopathological analyses. SUGAR demonstrated superior capability in visualizing urethral blood flow compared to CTA, allowing for detailed multiparametric analysis of UV, including fractal dimension, vessel density, tortuosity, diameter, and blood flow velocity. Strong correlations between SUGAR imaging and histopathological findings underscore its potential clinical applicability for diagnosing and managing urological conditions in humans.
Media Supplementation With Gamma‐Oryzanol Improves the Outcome of Ovine Oocyte Maturation In Vitro
Authors: Musapoor Saeed , Davoodian Najmeh , Kadivar Ali , Ahmadi Ebrahim , Nazari Hassan 
Published: December 2024

ABSTRACTBackgroundThe process of maturing ovine oocyte in vitro has not yet been raised with acceptable results.ObjectiveThis study was designed to evaluate the γ‐oryzanol effect as a supplement of maturation media on the development of ovine oocytes to blastocyst.MethodsAspirated from ovine ovaries, morphologically normal cumulus‐oocyte complexes (COCs) were matured in media supplemented with or without 5 µM γ‐oryzanol. Matured oocytes were divided into two parts: one evaluated for their nuclear maturation, the level of GSH and ROS, mitochondrial membrane potential (MMP) and the pattern of transcription in oocytes and respective cumulus cells (CCs), and another subjected to fertilisation and culture to assess the development of oocytes to the blastocyst.Resultsγ‐Oryzanol improved the proportion of cleaved embryos and total blastocysts in the treated group, which was linked to improved MMP, higher levels of intracellular GSH and lower levels of ROS. A lower proportion of MI and GVBD was recorded for treated oocytes in comparison with control, although the proportion of MII oocytes was not different between groups. The treated oocytes and CCs showed downregulation of genes related to apoptosis (BAX and CASP‐9) and upregulation of genes related to antioxidative status (NRF2, CAT and SOD). In conclusion, our results demonstrated the improved developmental outcome of supplemented oocytes so that the antioxidant response and higher enzymatic activity were maintained, and the generation of ROS was turned off; therefore, a novel alternative for counteracting oxidative stress in ovine oocytes undergoing maturation was offered by γ‐oryzanol through an antioxidative pathway.
Concomitant, Acquired Cavo‐Azygos Shunt and Spleno‐Gastroepiploic Bypass After Multiple Venous Obstruction in a Dog
Authors: Lee Seul , Kim Hyesun , Lee Kichang , Yoon Hakyoung 
Published: December 2024

ABSTRACTA 13‐year‐old intact female Shih Tzu presented with anorexia, panting and pain of unknown origin. Physical examination was normal except for a systolic murmur (grade 3/6). Abdominal radiographs revealed an ill‐defined area of increased opacity in the mid‐abdomen. A subsequent computed tomography (CT) scan confirmed a large, heterogeneously enhancing mass near the left adrenal gland, extensively invading the adjacent caudal vena cava, portal vein and splenic vein. This was accompanied by multiple metastatic lesions affecting the abdominal lymph nodes, lungs, liver and kidneys. Two distinct vascular anomalies were identified. The first was a shunt vessel that was diverting pre‐occlusive blood from the caudal vena cava to the azygos vein, causing dilation of the azygos vein and forming a cavo‐azygos shunt. The second was a significantly distended left gastroepiploic vein, forming a collateral pathway that rerouted blood from the splenic vein and ultimately drained into the gastroduodenal and portal vein. These findings are clinically significant as they demonstrate the formation of unique collateral pathways, specifically a cavo‐azygos shunt and spleno‐gastroepiploic bypass, which play a crucial role in maintaining venous drainage and systemic circulation in the presence of multiple venous obstructions. Recognizing such vascular anomalies through advanced imaging techniques like CT provides insights into underlying pathologies and aids in better clinical decision‐making for chronic venous obstructions in veterinary patients.
Management of Multiple Perianal Apocrine Hamartomas in a Poodle Dog Using Carbon Dioxide Laser
Authors: Kang Minjeong , Bae Hyeona , Yu DoHyeon 
Published: December 2024

ABSTRACTHamartoma is characterized by the abnormal proliferation of cells and tissues within the originating organ. Apocrine hamartoma (AH) affecting the skin, especially in the perianal area, has not yet been reported in dogs. A 7‐year‐old neutered male Poodle presented with multiple perianal papules and pruritus. Histopathological examination revealed significant enlargement of the apocrine glands and ducts, accompanied by mononuclear cell infiltration that extended into the subcutis. Given the location, number, depth and extent of the lesion, CO2 laser ablation was chosen over surgical resection. Complete recovery was observed at the surgical site 1 month after treatment, and pruritic symptoms were markedly reduced. CO2 laser ablation is a relatively safe and effective palliative treatment for perianal AH in dogs.
Antibiotic Susceptibility of Zoonotic Bacteria Isolated From Oral Cavities of Indigenous Dogs From Semi‐Urban Areas in Uganda
Authors: Mukasa Paul , Ogwang Patrick Engeu , Owor Richard Oriko , Lejju Julius B. , Gumisiriza Hannington , Ntulume Ibrahim , Adaku Christopher 
Published: December 2024

ABSTRACTDog bites are a source of zoonotic infections to humans, such as pasteurellosis and meningitis. Zoonotic bacterial identification and their antibiotic susceptibility assessment are key towards the successful management of such infections. This study isolated and identified zoonotic bacterial species from the oral cavities of indigenous dogs and also determined their antibiotic susceptibility profile. Oral swab samples collected from 54 indigenous dogs (domestic [36] and stray [18]) were cultured on agar media, and then on selective‐differential media. The colony morphology and conventional biochemical tests were used to identify the bacterial isolates. Antibiotic susceptibility was evaluated using the Kirby–Bauer disk diffusion method. A total of 232 bacterial isolates were obtained, from which 29 bacteria species (18 Gram‐negative and 11 Gram‐positive) belonging to 19 genera and 13 families were identified. Aerobic and anaerobic bacteria species constituted 69% and 31%, respectively. The most prevalent bacteria species was Staphylococcus aureus (10.8%) followed by Escherichia coli (9.5%), while Yersinia enterocolitica (0.4%) was the least common. Most bacteria species belonged to family Enterobacteriaceae (11) followed by Vibrionaceae (04). All the sampled dogs had a number of multi‐drug–resistant superbugs in their oral cavities. However, all the tested bacterial isolates were only susceptible to imipenem and chloramphenicol. All the identified bacteria species were resistant to metronidazole, amoxicillin‐clavulanic acid and ceftazidime. Therefore, antibiotics such as imipenem and chloramphenicol could be of better choice for managing dog bite infections compared to the antibiotics recommended by Uganda Clinical Guidelines, such as metronidazole and amoxicillin‐clavulanic acid.