bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body mass index and treatment survival in patients with RA starting treatment with TNFα-inhibitors: long-term follow-up in the real-life METEOR registry
Authors: Bergstra Sytske Anne , Allaart Cornelia F , Vega-Morales David , De Buck Marieke , Murphy Elizabeth , Salomon Escoto Karen , Huizinga Tom W J 
Published: June 2020

ObjectivesTo study whether there is an association between body mass index (BMI) category and survival of various tumour necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients in a real-life longitudinal international registry.MethodsData from 5230 patients with RA starting treatment with any TNFi were selected from the METEOR registry. Patients were divided into six BMI categories: 3.7% underweight, BMI<18.5 kg/m2; 46% normal weight, BMI 18.5–25 kg/m2; 32% pre-obesity, BMI 25–30 kg/m2; 13% obesity class I, BMI 30–35 kg/m2; 3.4% obesity class II, BMI 35–40 kg/m2; and 1.6% obesity class III, BMI >40 kg/m2. Time on treatment in the different BMI categories was compared for all TNFi combined and for the infliximab, adalimumab and etanercept separately, using Kaplan–Meier curves and Cox regression analyses. Cox regression analyses were adjusted for potential confounders, with follow-up censored at 5000 days.ResultsPatients in obesity class II (HR 1.28, 95% CI 1.06 to 1.54) and III (HR 1.67, 95% CI 1.29 to 2.18) and underweight patients (HR 1.30, 95% CI 1.07 to 1.58) showed statistically significantly shorter TNFi survival than normal weight patients. The effect in underweight patients was strongest for infliximab (HR 1.82, 95% CI 1.20 to 2.76), the effect in overweight patients was strongest for infliximab (category II (HR 1.49, 95% CI 0.98 to 2.26); category III (HR 1.46, 95% CI 0.79 to 2.71)) and etanercept (category II (HR 1.27 95% CI 0.98 to 1.65); category III (HR 1.79, 95% CI 1.25 to 2.55)). No significant effect modification from reported pain was found.ConclusionBoth underweight and overweight patients discontinued TNFi treatment earlier than normal weight patients, without evidence of reported pain as the main determinant. It remains uncertain what determines TNFi survival in individual patients.
Epicardial Interventions: Impact of Liposomal Bupivacaine on Postprocedural Management (The EPI-LIBRE Study)
Authors: Sharma Sharan Prakash , Turagam Mohit K. , Mohanty Sanghamitra , Di Biase Luigi , Burkhardt David , Horton Rodney , Natale Andrea , Lakkireddy Dhanunjaya 
Published: June 2020

Background:
Electrophysiological procedures such as epicardial ventricular tachycardia ablation and Lariat left atrial appendage ligation that involve the epicardial space are typically associated with significant postoperative pain due to mechanical irritation and associated inflammation. There is an unmet need for an effective pain management strategy in this group of patients. We studied how this impacts patient comfort and duration of hospitalization and other associated comorbidities related to pericardial access.

Methods:
This is a multicenter retrospective study including 104 patients who underwent epicardial ventricular tachycardia ablation and Lariat left atrial appendage exclusion. We compared 53 patients who received postprocedural intrapericardial liposomal bupivacaine (LB)+oral colchicine (LB group) and 51 patients who received colchicine alone (non-LB group) between January 2015 and March 2018.

Results:

LB was associated with significant lowering of median pain scale at 6 hours (1.0 [0–2.0] versus 8.0 [6.0–8.0],
P
<0.001), 12 hours (1.0 [1.0–2.0] versus 6.0 [5.0–6.0],
P
<0.001), and up to 48 hours postprocedure. Incidence of acute severe pericarditis delayed pericardial effusion and gastrointestinal adverse effects were similar in both groups. Median length of stay was significantly lower in LB group (2.0 versus 3.0; adjusted linear coefficient −1 [CI −1.3 to −0.6],
P
<0.001). Subgroup analysis demonstrated similar favorable outcomes in both Lariat and epicardial ventricular tachycardia ablation groups.

Conclusions:
Addition of intrapericardial postprocedural LB to oral colchicine in patients undergoing epicardial access during ventricular tachycardia ablation or Lariat procedure is associated with significantly decreased numeric pain score up to 48 hours compared with colchicine alone. It is also associated with significantly shorter length of hospital stay without an increase in the risk of adverse events.
Short‐Term Systolic Blood Pressure Variability and Kidney Disease Progression in Patients With Chronic Kidney Disease: Results From C‐STRIDE
Authors: Wang Qin , Wang Yu , Wang Jinwei , Zhang Luxia , Zhao Ming‐Hui , Wang Xiaoqin , Yuan Jun , Zhou Qiaoling , Yuan Qiongjing , Chen Menghua , Zhou Xiaoling , Fu Shuxia , Li Shaomei , Zha Yan , Huang Rongsai , Liu Zhangsuo , Zhang Jun , Wang Li , Pu Lei , Liu Jian , Li Suhua , Xiong Zuying , Liang Wei , Zhao Jinghong , Mu Jiao , Lian Xiyan , Liao Yunjuan , Gan Hua , Liao Liping , Wang Rong , Lv Zhimei , Liao Yunhua , Pan Ling , Yang Xiaoping , Lin Zhifeng , Tong Zongwu , Zhu Yun , He Qiang , Wu Fuquan , Li Rong , Rong Kai , Wang Caili , Zhang Yanhui , Wang Yue , Tang Wen , Wu Hua , Zhao Ban , Li Rongshan , Wang Lihua , Li Detian , Du Feng , Wu Yonggui , Zhang Wei , Lin Shan , Xu Pengcheng , Lin Hongli , Hu Zhao , Pei Fei , Zhang Haisong , Gao Yan , Sun Luying , Li Xia , Wang Wenke , Lv Fengling , Wang Deguang , Wang Xuerong , Xu Dongmei , Tang Lijun , Ma Yingchun , Wang Tingting , Fu Ping , Wang Tingli , Xing Changying , Zhang Chengning , Xu Xudong , He Haidong , Liao Xiaohui , Xie Shuqin , Hu Guicai , Huang Lan 
Published: June 2020

Background
It is unclear whether short‐term blood pressure variability is associated with renal outcomes in patients with chronic kidney disease.

Methods and Results

This study analyzed data from participants in the C‐
STRIDE
(Chinese Cohort Study of Chronic Kidney Disease) who had
chronic kidney disease
stages 1 to 4. Short‐term
blood pressure variability
was measured by calculating the weighted SD (w‐
SD
) of systolic blood pressure (
SBP
). Renal outcomes were defined as dialysis initiation and/or transplantation. Risk factors associated with w‐
SD
of
SBP
were evaluated by linear regression. Associations of short‐term SBP variability with renal outcomes were evaluated by Cox regression. In total, 1421 patients with
chronic kidney disease
were included in this study (mean age, 49.4±13.6 years; 56.2% men; estimated glomerular filtration rate, 50.5±29.3 mL/min per 1.73 m
2
; proteinuria, 0.9 [0.3–2.0] g/d). Mean w‐
SD
of
SBP
was 12.6±4.4 mm Hg. w‐
SD
of
SBP
was independently associated with older age, 24‐hour
SBP
, blood pressure circadian pattern, and angiotensin
II
receptor blocker treatment. During a median follow‐up of 4.9 years, 237 patients developed renal outcomes (37.01 per 1000 patient‐years). The incidence rate increased across the quartiles of w‐
SD
(log‐rank
P
=0.005). w‐
SD
of
SBP
was associated with an increased risk of renal outcomes, both as a continuous variable (hazard ratio [HR], 1.47; 95% CI, 1.09–1.99) and as a categorical variable (quartile 4 versus quartile 1: HR, 1.60; 95% CI, 1.08–2.36), independent of 24‐hour
SBP
, daytime
SBP
, and nighttime
SBP
.

Conclusions

Short‐term SBP was independently associated with the risk of dialysis initiation and/or transplantation in patients with
chronic kidney disease
.
A Number of Books
Authors: van Capelleveen Paul 
Published: June 2020

Abstract
During the twentieth century, a limited edition is usually numbered, in contrast to limited editions of around 1800. This article examines a number of turning points in the history of limitation statements and copy numbering: the disappearance of copyright related numbering versus unnumbered editions of private presses (around 1800), the advent of numbered prints (1850-1900), and numbering of luxury editions and private press editions (1880-1910). The stabilization of a new tradition of numbering occurs around 1930. The development of private press publications is examined in a broad context of copyright and the production of prints, while practices in the English-speaking world are shown to differ from those in other cultures, such as the Netherlands, Belgium, France and Germany.
The Art of Printing in the Dutch East Indies
Authors: Kuitert Lisa 
Published: June 2020

Abstract
In the Netherlands, and elsewhere, too, Laurens Janszoon Coster of Haarlem, and not Gutenberg, was long thought to have been the inventor of the art of printing. The myth—for that is what it was—was only definitively repudiated at the end of the nineteenth century, though some continued to believe in Coster until their dying breath. The Coster myth was deployed to give the history of the Netherlands status and international prestige. This article concerns the extent to which Coster’s supposed invention was known in the Dutch East Indies—today’s Indonesia, a Dutch colony at that time—and what its significance was there. After all, heroes, national symbols and traditions, whether invented or not, are the building blocks of cultural nationalism. Is this also true for Laurens Janszoon Coster in his colonial context?
Chrestiani, Christiani, Χριστιανοί: a Second Century Anachronism?
Authors: Granger Cook John 
Published: June 2020

Abstract
Brent D. Shaw has questioned the historicity of the Neronian persecution based on two arguments from silence: Tacitus’s use of the term “Christians” is an anachronism; and Suetonius knows of no connection between the fire in Rome and Nero’s police actions against the Christians. Both of these untestable arguments from silence are inherently weak logically. One can make a good case for the claim that Chrestianus, Christianus, and Χριστιανός are not creations of the second century and that Roman officials were probably aware of the Chrestiani in the 60s. Tacitus’s and Suetonius’s accounts of the persecution are fundamentally reliable.
Augustine’s Utilization of Rhetorical Economy in His Early Theology of Creation (On Genesis against the Manichaeans 1.21.32)
Authors: Gronewoller Brian 
Published: June 2020

Abstract
While the majority of previous scholarship on Augustine’s theology has treated his references to rhetorical concepts as incidental, Robert Dodaro (2004), Michael Cameron (2010), Mark Clavier (2014) and Adam Ployd (2017), have recognized recently that Augustine incorporated sundry aspects of rhetorical theory into his theology in a consequential manner. In this article I advance this new scholarly movement in two ways. First, I show that Augustine also used rhetorical theory in a consequential manner in his early theology of creation; I argue that Augustine utilized the rhetorical concept of economy (oeconomia) as the logic justifying God’s declaration that the completed creation was “very good” (Gen 1.31) by means of a close reading of De Genesi aduersus Manichaeos 1.21.32. Secondly, I combine my findings in this article with previous research to contend that future scholarship on Augustine’s theology should treat his references to rhetorical concepts as potentially consequential.
“Mocked by the Archon of Lust”
Authors: Linjamaa Paul 
Published: June 2020

Abstract
This article argues that the depictions of Gnostic sects performing horrendous rites in Epiphanius of Cyprus’ work Panarion worked as rhetorical devices to shift focus away from his own position vis-à-vis marriage, sex, and consumptions of good food and wine, a position that was considered liberal in the context of fourth century ecclesiastical debates. It here is shown how Epiphanius’ description of Gnostic sects follows clear patterns of the archetypical “other”, going back to Roman slander of Christians. By drawing attention to this fact and by contextualizing Epiphanius’ theological positions and the ecclesiastical struggles he was engaged in during the fourth century, this article cast new light on the work Panarion and the techniques Epiphanius employed in order to impact his theological climate. By retorting to conventional polemical methods of preceding centuries, where the enemy is attached to norm-breaking behavior, Epiphanius managed to make his own positions seem more reasonable and moderate.
Genetic Material and Sequence Data to Protect Global Health in the Light of Pandemic Outbreaks: Mapping the Legal Landscape under European and International Law
Authors: Seitz Claudia 
Published: June 2020

Abstract
The current pandemic outbreak of corona virus SARS-CoV-2 shows the need for comprehensive European cooperation in drug development and the importance of genetic material and sequence data in research concerning this unknown disease. As corona virus SARS-CoV-2 is spreading across Europe and worldwide, national authorities and the European Union (EU) institutions do their utmost to address the pandemic and accelerate innovation to protect global health. In order to be prepared and to be able to respond immediately to serious epidemic and pandemic diseases, the EU has already adopted the Decision No (EU) 1082/2013 on serious cross-border threats to health. The World Health Organization (WHO) has established a global system to collect genetic material and information to protect a global influenza pandemic outbreak. The article describes the current legal landscape under EU and international law.
The Copper Plates of Helagupta
Authors: Salomon Richard 
Published: June 2020

Abstract
The article presents a new edition, translation, and interpretation of the inscription, which was previously published by H. Falk in 2014, of the otherwise unknown Buddhist patron Helagupta (helaüta). The inscription, datable to the latter half of the first century CE, is recorded on five copper plates and is the second longest one known in Kharoṣṭhī script/Gāndhārī language. This edition proposes several new readings and interpretations as well as discussing its cultural implications for issues such as the performance of ancestral rituals by Buddhists, and Buddhological ramifications such as the concept of “brahma merit” (Gāndhārī bramo puṇyo) and the contemporary understanding of variant forms of titles of the Buddha.
Portraying Race beyond Ellis Island: The Case of Lewis Hine
Authors: Ureña Leslie 
Published: June 2020

Lewis Hine first went to New York’s Ellis Island Immigration Station to take photographs that would elicit sympathy from his students at the Ethical Culture School toward the new immigrants. Since then, the photographs, dating from 1905 to 1926, have visually defined his sitters as foreigners in classrooms, in print, and at museums. Produced at a time when the so-called race of the foreign-born was deemed indicative of their overall character and abilities, the photographs both sustained and countered turn-of-the-century racialized conceptualizations of newcomers. More recently, contemporary artists including JR and Tomie Arai have returned to Hine’s Ellis Island work for installations that bring the past into direct dialogue with the present, confronting contemporary viewers with enlarged versions of his photographs. Hine’s pro-immigrant intentions and reputation as a social reform photographer, however, have clouded how these photographs also racialized their sitters. This article traces the circulation of a selection of Hine’s works in different contexts dating from 1905 to today, and considers them within the broader histories and theories of photography, race, and immigration.
On a Cross-Cultural Memescape: Switzerland through Nation Memes from within and from the Outside
Authors: Dynel Marta , Messerli Thomas C. 
Published: June 2020

Abstract
This paper offers a cross-cultural contrastive study of what we term ‘nation memes’. These are humorous internet memes which refer to a particular country/nation. Our analysis of cultural scripts in memes related to Switzerland is based on a tripartite corpus of digital items shared by Polish, Swiss and international communities. By adopting a grounded-theory approach, we examine the prevalent scripts that represent the Swiss and Switzerland from each of the three perspectives. The results of our qualitative study indicate that Swiss memes are based on experiential knowledge of life in Switzerland, as well as a few stereotypes adopted by the Swiss about their own nation. The Polish subcorpus addresses Switzerland from an outsider perspective by invoking well-known cultural scripts, similar to those on international websites, on which Polish users sometimes scavenge. However, the Polish memescape uses scripts about Switzerland to address problems and scripts specific to Poland. Importantly, nation memes do not necessarily involve humorous disparagement, i.e. they do not always take Switzerland/the Swiss to be the target at which to poke fun when building humorous superiority. Moreover, by referring to their own national vices, the Swiss and Poles sometimes use cultural scripts as the basis for self-deprecating humour.
Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice
Authors: Lysenko Veronika , Wildner-Verhey van Wijk Nicole , Zimmermann Kathrin , Weller Marie-Christine , Bühler Marco , Wildschut Mattheus H. E. , Schürch Patrick , Fritz Christine , Wagner Ulrich , Calabresi Laura , Psaila Bethan , Flavell Richard A. , Vannucchi Alessandro M. , Mead Adam J. , Wild Peter J. , Dirnhofer Stefan , Manz Markus G. , Theocharides Alexandre P. A. 
Published: June 2020

Abstract
The engraftment potential of myeloproliferative neoplasms in immunodeficient mice is low. We hypothesized that the physiological expression of human cytokines (macrophage colony-stimulating factor, interleukin-3, granulocyte-macrophage colony-stimulating factor, and thrombopoietin) combined with human signal regulatory protein α expression in Rag2−/−Il2rγ−/− (MISTRG) mice might provide a supportive microenvironment for the development and maintenance of hematopoietic stem and progenitor cells (HSPC) from patients with primary, post–polycythemia or post–essential thrombocythemia myelofibrosis (MF). We show that MISTRG mice, in contrast to standard immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ and Rag2−/−Il2rγ−/− mice, supported engraftment of all patient samples investigated independent of MF disease stage or risk category. Moreover, MISTRG mice exhibited significantly higher human MF engraftment levels in the bone marrow, peripheral blood, and spleen and supported secondary repopulation. Bone marrow fibrosis development was limited to 3 of 14 patient samples investigated in MISTRG mice. Disease-driving mutations were identified in all xenografts, and targeted sequencing revealed maintenance of the primary patient sample clonal composition in 7 of 8 cases. Treatment of engrafted mice with the current standard-of-care Janus kinase inhibitor ruxolitinib led to a reduction in human chimerism. In conclusion, the established MF patient-derived xenograft model supports robust engraftment of MF HSPCs and maintains the genetic complexity observed in patients. The model is suited for further testing of novel therapeutic agents to expedite their transition into clinical trials.
Chromosome aberrations in pressure-induced triploid Atlantic salmon
Authors: Glover K. A. , Harvey A. C. , Hansen T. J. , Fjelldal P. G. , Besnier F. N. , Bos J. B. , Ayllon F. , Taggart J. B. , Solberg M. F. 
Published: June 2020

Abstract
Background
Triploid organisms have three sets of chromosomes. In Atlantic salmon, hydrostatic pressure treatment of newly fertilized eggs has been extensively used to produce triploids which are functionally sterile due to their unpaired chromosomes. These fish often perform poorly on commercial farms, sometimes without explanation. Inheritance patterns in individuals subjected to pressure treatment have not been investigated in Atlantic salmon thus far. However, work on other species suggests that this treatment can result in aberrant inheritance. We therefore studied this in Atlantic salmon by genotyping 16 polymorphic microsatellites in eyed eggs and juveniles which had been subjected to pressure-induction of triploidy. Communally reared juveniles including fish subjected to pressure-induction of triploidy and their diploid siblings were included as a control.

Results
No diploid offspring were detected in any of the eggs or juveniles which were subjected to hydrostatic pressure; therefore, the induction of triploidy was highly successful. Aberrant inheritance was nevertheless observed in 0.9% of the eggs and 0.9% of the juveniles that had been subjected to pressure treatment. In the communally reared fish, 0.3% of the fish subjected to pressure treatment displayed aberrant inheritance, while their diploid controls displayed 0% aberrant inheritance. Inheritance errors included two eyed eggs lacking maternal DNA across all microsatellites, and, examples in both eggs and juveniles of either the maternal or paternal allele lacking in one of the microsatellites. All individuals displaying chromosome aberrations were otherwise triploid.

Conclusions
This is the first study to document aberrant inheritance in Atlantic salmon that have been subjected to pressure-induction of triploidy. Our experiments unequivocally demonstrate that even when induction of triploidy is highly successful, this treatment can cause chromosome aberrations in this species. Based upon our novel data, and earlier studies in other organisms, we hypothesize that in batches of Atlantic salmon where low to modest triploid induction rates have been reported, aberrant inheritance is likely to be higher than the rates observed here. Therefore, we tentatively suggest that this could contribute to the unexplained poor performance of triploid salmon that is occasionally reported in commercial aquaculture. These hypotheses require further investigation.
Effects of dexmedetomidine on stress hormones in patients undergoing cardiac valve replacement: a randomized controlled trial
Authors: Wu Hanhua , Tang Jinqing , Pan Jiamei , Han Ming , Cai Huijun , Zhang Hong 
Published: June 2020

Abstract
Background
Stress response always occurs in cardiac valve replacement patients undergoing cardiopulmonary bypass (CPB).

Methods
60 patients undergoing cardiac valve replacement were recruited and randomized into control and Dex groups. Dex group received 1.0 μg·kg-1 of Dex for 10 min intravenously before anesthesia, followed by 0.5 μg·kg-1·h-1 of Dex, steadily administered throughout the procedure. And controlled group received the identical velocity of saline as Dex group. Plasma level of cortisol (Cor), epinephrine (E), norepinephrine (NE), and serotonin (5-HT) were evaluated at four timepoints: Before administration (T0), sawn sternum (T1), end of extracorporeal circulation (T2), and 24 h post operation (T3). General data of operation and recovery such as heart rate (HR), mean arterial pressure (MAP), intraoperative bispectral index (BIS), and hospitalization time in the intensive care unit (ICU) were also compared.

Results
Increase of Cor, E, NE, and 5-HT for the Dex group was significant lesser than that in the control group (P < 0.05), and ICU hospitalization time and ventilator support time was significantly shorter in the Dex group. The proportion of patients discharged from the hospital with better prognosis was significantly higher than that in the control group, while there were no significant differences in hospitalization costs and vasoactive drugs use between the two groups.

Conclusions
Dex reduces plasma Cor, E and NE elevations in patients after CPB, alleviates the stress reaction of the body, shortens the hospitalization time and ventilator support time in ICU, and plays a positive role in the rehabilitation of patients undergoing cardiac valve replacement.

Trial registration
China Clinical Trial Registry (No. ChiCTR-IPR-17010954) March 22rd, 2017.