bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efeito imediato da MWM de Mulligan em pacientes com dor no ombro
Authors: Dias Daniela , Beltrão Vítor Pinto , Silveira César Diniz , Silva Fernanda Régis , Silva Matheus Henrique Almeida , Araújo Roberto Paulo Correia 
Published: October 2020

<p><strong>Introdução</strong>: a dor no ombro leva a limitações e incapacidades entre adultos e idosos, merecendo atenção do fisioterapeuta. <strong>Objetivo</strong>:<br />Avaliar o efeito imediato da técnica de Mulligan em pacientes com dor no ombro. <strong>Metodologia</strong>: trata-se de resultados preliminares<br />de um ensaio clínico realizado entre julho de 2018 a julho de 2019. Pacientes com dor no ombro (n=44), de ambos os sexos, foram<br />randomizados e submetidos a dois protocolos de tratamento: exercícios terapêuticos (n=22) e MWM de Mulligan (n=22), atendidos na<br />Clínica Escola de Fisioterapia da UFBA. Todos os participantes responderam a um questionário clínico e sociodemográfico e realizaram<br />avaliação da dor pela escala visual analógica (EVA) e algometria. Os pacientes foram tratados por dois fisioterapeutas experientes na<br />área e, depois, foram reavaliados imediatamente. <strong>Resultados</strong>: mulheres predominaram, a média de idade foi de 56 anos no grupo<br />Mulligan e 57 no grupo exercícios terapêuticos. Síndrome do manguito rotador predominou: 19 (86,4%) no grupo Mulligan e 15 (68%)<br />no grupo exercícios. O ombro mais acometido foi o direito no Grupo Mulligan, (17 (77,3%); já no grupo exercícios, foi o esquerdo com<br />12 (55%). A cor negra foi a mais autorrelatada pelos pacientes, e poucos tinham o ensino superior completo. No grupo Mulligan, as<br />ocupações mais informadas foram dona de casa, seguida de aposentados e autônomos. No grupo exercícios, não houve dona de casa,<br />e sim mais aposentados e autônomos. Os dois grupos mostraram ser mais sedentários. Não houve diferença da dor pela EVA entre<br />os grupos, antes e após o tratamento (p=0.79, p=0.56, respectivamente). Já a intensidade da dor mensurada pela algometria, tanto antes do tratamento (p=0.008) quanto depois do tratamento (p=0.04), foi diferente entre os grupos, com predomínio de melhora<br />no grupo Exercícios. <strong>Conclusão</strong>: a MWM não foi mais eficaz que os exercícios terapêuticos na redução da dor do ombro, sendo que<br />o exercício apresentou mais eficácia quando medido através da EVA e sem melhora significativa ao ser mensurada pela algometria<br />após aplicação de uma única sessão de tratamento.</p>
Tribolium castaneum como modelo experimental para estudos em metabolismo de carboidratos e lipídeos: uma prospecção tecnológica
Authors: Silva Meirielly Kellya Holanda , Batalha Mariana Macêdo Costa , Dornelas Camila Braga , Grillo Luciano Aparecido Meireles 
Published: October 2020

<p> </p><p class="MsoNormal" style="margin-bottom: 6.0pt; text-align: justify;">Neste artigo realizou-se uma prospecção tecnológica com o objetivo de analisar pedidos de depósitos de patentes referentes à utilização do <em style="mso-bidi-font-style: normal;">Tribolium castaneum</em> como modelo experimental para estudos em metabolismo de carboidratos e lipídios, por meio de patentes das bases de dados PatentScope e Espacenet, e artigos científicos da PubMed. A maioria dos pedidos de depósitos se refere a repelentes de pestes/controle de pragas, o que é explicado pelo fato de o <em style="mso-bidi-font-style: normal;">Tribolium castaneum</em> ser uma das principais pragas de grãos armazenados com distribuição mundial. Dessa forma, nenhum dos pedidos analisados se refere à sua utilização como modelo experimental para estudos em metabolismo de carboidratos e lipídios, assim como não se encontrou artigo científico explicitando seu desenvolvimento. Diante dessa lacuna, conclui-se que esta é uma área tecnológica pouco explorada e potencialmente útil para novas pesquisas e produtos.</p><p></p>
Prospecção Tecnológica de Águas Micelares
Authors: Girdzyasuskas Justino Yasmin , Freire Leite Mateus 
Published: October 2020

<p> </p><p class="MsoNormal"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif;">A constante busca e manutenção da beleza pela humanidade desde a antiguidade faz com que indústrias do mercado de cosméticos busquem cada vez mais formas e produtos inovadores para agregar em seu acervo. A tecnologia das águas micelares entra no acervo de produtos inovadores para saciar as necessidades dos consumidores. O presente trabalho tem como objetivo produzir uma prospecção tecnológica sobre águas micelares e suas tecnologias, a fim de identificar perspectivas de mercado para essa área tecnológica. Para a produção do estudo, foram desenvolvidas revisões bibliográficas e buscas na base patentária <a name="_Hlk20173459">do Banco Europeu de Patentes (ESPACENET)</a>. Posteriormente, foi realizada análise qualitativa e quantitativa dos dados obtidos, observando-se que a primeira patente depositada relacionada ao assunto foi no ano de 1984, constatou-se, portanto, que houve apenas 20 depósitos ao longo de 35 anos e tendo que o Japão é o principal país depositante. Os resultados obtidos demonstram a necessidade do aumento de pesquisas e patentes sobre o tema, mostrando boas perspectivas de inovação na área.</span></p><p></p>
Lenin e a desintegração do campesinato russo
Authors: Da Silva Marizete Andrade 
Published: October 2020

<p>Longe do caráter ilusório do fortalecimento do campesinato, Lenin formulou a tese de que o conjunto de contradições existentes no interior do campesinato russo representava um fenômeno que constituía a base por meio da qual se formava o mercado interno da produção capitalista e se originavam novos tipos rurais. Neste sentido pretendemos abordar alguns aspectos centrais sobre a desintegração do campesinato russo no pensamento leniniano durante o final do século XIX e a primeira década do século XX, enfatizando a estratégia utilizada pela política revolucionária para persuadir a classe transitória e vacilante dos camponeses médios a aliar-se aos operários na luta pela construção do socialismo.</p>
Recent Advances in the Synthesis of Intra‐Nanogap Au Plasmonic Nanostructures for Bioanalytical Applications
Authors: Yang Wonseok , Lim Dong‐Kwon 
Published: October 2020

AbstractPlasmonic nanogap‐enhanced Raman scattering has attracted considerable attention in the fields of Raman‐based bioanalytical applications and materials science. Various strategies have been proposed to prepare nanostructures with an inter‐ or intra‐nanogap for fundamental study models or applications. This report focuses on recent advances in synthetic methods to fabricate intra‐nanogap structures with diverse dimensions, with detailed focus on the theory and bioanalytical applications. Synthetic strategies ranging from the use of a silica layer to small molecules, the use of polymers and galvanic replacement, are extensively investigated. Furthermore, various core structures, such as spherical, rod‐, and cube‐shaped, are widely studied, and greatly expand the diversity of plasmonic nanostructures with an intra‐nanogap. Theoretical calculations, ranging from the first plasmonic hybridization model that is applied to a concentric Au–SiO2–Au nanosphere to the modern quantum corrected model, have evolved to accurately describe the plasmonic resonance property in concentric core–shell nanostructures with a subnanometer nanogap. The greatly enhanced and uniform Raman responses from the localized Raman reporter in the built‐in nanogap have made it possible to achieve promising probes with an extraordinary high sensitivity in various formats, such as biomolecule detection, high‐resolution cell imaging, and an in vivo imaging application.
Different Modes of Deformation of Soft Triangular Honeycombs at the Sub‐5 nm Scale
Authors: Poppe Marco , Chen Changlong , Poppe Silvio , Kerzig Christoph , Liu Feng , Tschierske Carsten 
Published: October 2020

AbstractPatterning on the sub‐5 nm length scale is a contemporary challenge for further miniaturization of microelectronic circuits. Here, the first soft self‐assembled triangular patterns are reported showing transitions between regular and two different kinds of isosceles (acute and obtuse angled) triangles on this length scale, formed by liquid crystalline honeycombs of polyphilic block molecules involving a fluorinated oligo(para‐phenylene ethynylene) core. The type of formed triangular pattern depends on the degree and position of fluorination and on temperature. They are the first soft honeycombs combining tilted and nontilted organizations in a uniform nanostructure, where the tilted molecules in only one or two sides of the triangular prismatic cells dominate the shape and the size of the morphology.
Are College Students More Likely to Be Food Insecure than Nonstudents of Similar Ages?
Authors: Gundersen Craig 
Published: October 2020

Abstract“College hunger” has received a great deal of attention in the media and on some campuses across the US. In this article, I consider the question: Are college students more likely to be food insecure than those of similar ages who are not in college? To answer this question, I use data from the 2014 to 2018 Current Population Survey (CPS), the data used for the official food insecurity rates in the US. Across many specifications, I find zero evidence that college students are at higher risk of food insecurity than nonstudents. This holds whether one looks at those between the ages of eighteen and twenty‐five or between twenty‐six and thirty; whether one looks at “person is a child of the respondent” or “person is not a child of the respondent”; or whether one looks at demographic categories. In fact, food insecurity rates are up to twice as high among nonstudents in comparison to full‐time college students.
Waiting for a diagnosis in Rubinstein–Taybi: The journey from “ignorance is bliss” to the value of “a label”
Authors: Withers Chelsea M. , Fleming Jane , Wallingford Courtney K. , Gabbett Michael T. , Peterson Madelyn , Humphreys Linda , McInerney‐Leo Aideen 
Published: October 2020

AbstractThe journey to receiving a diagnosis for rare genetic disease can be long and emotionally impactful. This study describes parental experiences of receiving their child's diagnosis of Rubinstein–Taybi syndrome (RTS), a rare genetic condition characterized by growth and developmental delay together with dysmorphic features. Parents from the RTS Australia support group participated in qualitative, semi‐structured phone interviews, which were transcribed verbatim and thematically analyzed. Questions focused on psychosocial challenges and benefits pre and post‐diagnosis. Ten mothers and three fathers participated, with the mean age of diagnosis being 8 months. Parents reported positive psychological effects from a slight delay in diagnosis, and negative effects from an extended diagnostic delay, suggesting the ideal time for a parent to receive a diagnosis lies in the post attachment stage, prior to the development of significant parental concerns. This stage would vary depending on condition severity. Parents desired a diagnosis to reduce uncertainty; however, uncertainty remained post diagnosis, and shifted its focus from broadly encompassing etiology and prognosis, to specifically focusing on concerns regarding severity within the spectrum. Perceived benefits of a diagnosis mainly centered on the provision of a label. Parents articulated that a label increased social acceptance, enhanced coping, promoted communication, and improved access to medical, financial, and support services. This study provides insights into the experience of families prior to and following receipt of a diagnosis. It also highlights the possibility of an optimal time window to receive a diagnosis; in which bonding is maximized and parental distress is minimized.
Unexpected awakenings in severe dementia from case reports to laboratory
Authors: Bostanciklioğlu Mehmet 
Published: October 2020

AbstractObjectiveCase report notions of unexpected memory retrieval in patients with severe dementia near to death are starting to alter the central “irreversible” paradigm of dementia and locate dementia as a problem of memory retrieval, not consolidation. We suggest that the most likely central tenet of this paradoxical memory retrieval is the fluctuation of neuromodulators projecting from the brain stem to the medial prefrontal cortex and the hippocampus. The neuromodulation‐centric explanation of this phenomenon aims to open the “irreversible” paradigm of dementia up for discussion and suggest a plausible treatment strategy by questioning how the devastating process of death fluctuates memory performance in severe dementia.BackgroundSupporting demented patients, who are mostly unresponsive, without making demands or asking a question and regarding them as valuable human beings unexpectedly improve their memory performance around the time of death.New lucidity hypothesisAround the time of death, neurological signs (hyper‐arousal and ‐attention) of demented people point out that neurotransmitter discharges are dramatically changed. Relatively resistant neuromodulator circuits to neurodegeneration can maintain optimal levels of arousal and attention for memory processing. In this way, unexpected episodes of lucidity can be triggered. Also, corticotropin‐releasing peptides might increase mental clarity by increasing the excitability of the neuromodulator circuits. The science of memory retrieval is more complicated and nuanced than retrieval observations in case reports, but the rapid development of new techniques holds promise for future understanding of lucidity in severe dementia.Major challenge for the modelThere is no an animal or human model to test this hypothesis; however, the similarities between neurological signs (instantaneous cognitive fluctuations) of delirium and paradoxical lucidity could provide a unique window to understand neural events of terminal lucidity on a modified animal model of delirium. Likewise, similarities between unexpected consciousness signs of terminal lucidity and lucid dreaming suggest that lucid dreaming episodes might be considered a human model for terminal lucidity research.
The SSV‐Seq 2.0 PCR‐Free Method Improves the Sequencing of Adeno‐Associated Viral Vector Genomes Containing GC‐Rich Regions and Homopolymers
Authors: Lecomte Emilie , Saleun Sylvie , Bolteau Mathieu , Guy‐Duché Aurélien , Adjali Oumeya , Blouin Véronique , Penaud‐Budloo Magalie , Ayuso Eduard 
Published: October 2020

AbstractAdeno‐associated viral vectors (AAV) are efficient engineered tools for delivering genetic material into host cells. The commercialization of AAV‐based drugs must be accompanied by the development of appropriate quality control (QC) assays. Given the potential risk of co‐transfer of oncogenic or immunogenic sequences with therapeutic vectors, accurate methods to assess the level of residual DNA in AAV vector stocks are particularly important. An assay based on high‐throughput sequencing (HTS) to identify and quantify DNA species in recombinant AAV batches is developed. Here, it is shown that PCR amplification of regions that have a local GC content >90% and include successive mononucleotide stretches, such as the CAG promoter, can introduce bias during DNA library preparation, leading to drops in sequencing coverage. To circumvent this problem, SSV‐Seq 2.0, a PCR‐free protocol for sequencing AAV vector genomes containing such sequences, is developed. The PCR‐free protocol improves the evenness of the rAAV genome coverage and consequently leads to a more accurate relative quantification of residual DNA. HTS‐based assays provide a more comprehensive assessment of DNA impurities and AAV vector genome integrity than conventional QC tests based on real‐time PCR and are useful methods to improve the safety and efficacy of these viral vectors.
Fast and easy quantitative characterization of methanotroph–photoautotroph cocultures
Authors: Badr Kiumars , Whelan William , He Q. Peter , Wang Jin 
Published: October 2020

AbstractRecent research has demonstrated that synthetic methanotroph–photoautotroph cocultures offer a highly promising route to convert biogas into value‐added products. However, there is a lack of techniques for fast and accurate characterization of cocultures, such as determining the individual biomass concentration of each organism in real‐time. To address this unsolved challenge, we propose an experimental–computational protocol for fast, easy, and accurate quantitative characterization of the methanotroph–photoautotroph cocultures. Besides determining the individual biomass concentration of each organism in the coculture, the protocol can also obtain the individual consumption and production rates of O2 and CO2 for the methanotroph and photoautotroph, respectively. The accuracy and effectiveness of the proposed protocol was demonstrated using two model coculture pairs, Methylomicrobium alcaliphilum 20ZR–Synechococcus sp. PCC7002 that prefers high pH high salt condition, and Methylococcus capsulatus–Chlorella sorokiniana that prefers low salt and neutral pH medium. The performance of the proposed protocol was compared with a flow cytometry‐based cell counting approach. The experimental results show that the proposed protocol is much easier to carry out and delivers faster and more accurate results in measuring individual biomass concentration than the cell counting approach without requiring any special equipment.
Undergraduate education in biochemistry and molecular biology: A parallel session at the IUBMB/PSBMB 2019 “Harnessing Interdisciplinary Education in Biochemistry and Molecular Biology” conference
Authors: Amor Evangeline C. , Attanayake Anoja P. , G. Nicolas Marilou , Yu Gracia Fe B. , Macaulay Janet O. 
Published: October 2020

AbstractAlthough science education, including biochemistry and molecular biology education, starts before students commence university, for many students, undergraduate programs are their first real introduction to biochemistry and molecular biology. Students often report that biochemistry and molecular biology are relatively difficult topics hence the use of varied and well‐thought‐out approaches are critical to fully engage students. This session provided insights into undergraduate curriculum design.
Evaluation of the effect of Dahuang–Mudan decoction on TNBS‐induced colitis using UPLC–QTOF/MS‐based metabolomic analysis
Authors: Nong Feifei , Luo Shuang , Liang Yuqi , Zhao Zhongxiang , Xing Shangping , Wen Bin , Zhou Lian 
Published: October 2020

AbstractDahuang–Mudan decoction (DMD) is a formula that has been widely used as a complementary treatment for inflammatory bowel disease (IBD). However, the mechanism of action of DMD in IBD has not been clearly elucidated. Therefore, we developed a metabolomics‐based method to evaluate the effects and potential mechanisms of DMD in a 2,4,6‐trinitobenzene sulfonic acid (TNBS)‐induced colitis model. The ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry (UPLC/QTOF–MS) method combined with multiple analysis approaches including principal component analysis, partial least square discriminant analysis and orthogonal partial least square discriminant analysis were used to investigate the different urinary metabolites. We identified 29 potential biomarkers of TNBS‐induced colitis that returned to normal conditions after DMD administration. Pathway analysis indicated that changes in these metabolites were associated with cysteine and methionine metabolism, citric acid cycle, glycolysis and glycolic regeneration, pyruvate metabolism, biosynthesis of valine, leucine and isoleucine, biosynthesis of primary bile acids, glycine, serine and threonine metabolism, caffeine metabolism, arginine and proline metabolism and phenylalanine metabolism. It is worth noting that DMD has potential therapeutic effects on TNBS‐induced colitis, which functions by restoring the balance of multiple disturbed pathways to a normal condition. This study suggests the reliability of metabolomics‐based approaches to identifying biomarkers and pathways, which facilitate further investigation of the potential mechanisms of DMD.
Clinical outcomes of non‐osteogenic, non‐Ewing soft‐tissue sarcoma of bone––experience of the Toronto Sarcoma Program
Authors: Veitch Zachary W. , Fasih Samir , Griffin Anthony M. , Al‐Ezzi Esmail M. , Gupta Abha A. , Ferguson Peter C. , Wunder Jay S. , Abdul Razak Albiruni R. 
Published: October 2020

AbstractNon‐osteogenic, non‐Ewing soft‐tissue sarcoma (NONE‐STS) of bone is a rare presentation of primary bone cancers. Optimal treatments and outcomes for this heterogenous group are poorly described. We evaluated the factors associated with long‐term outcomes in patients with this disease. Patients with localized NONE‐STS of bone treated at the Toronto Sarcoma Program from 1987 to 2017 were identified. Clinical characteristics, treatment, and survival information were collected. Kaplan‐Meier (log‐rank) survival estimates from the time of definitive surgery, with uni‐/multivariate analyses (Cox) of sarcoma‐specific survival were performed. A total of 106 patients (60.4% male; median age 46 years) with NONE‐STS of bone were identified. Common histologies included undifferentiated pleomorphic sarcoma [UPS]/malignant fibrous histiocytoma [MFH] (UPS/MFH, 41.5%), leiomyosarcoma (LMS, 20.8%), and fibrosarcoma (FS, 11.3%). Tumors were often high grade (59.4%) and involved the extremities (88.7%), with most receiving chemotherapy (67.9%) with cisplatin/doxorubicin‐based regimens (73.6%). In the full cohort, 10‐year DFS (45.7%, [95%CI: 35.7‐55.8%]), OS (53.4%, [95%CI: 41.7‐62.2%]), and SSS (63.9%, [95%CI: 53.9‐72.5%]) were moderate. Histology specific, 10‐year SSS was 70.7% [95%CI: 56.1‐85.5%] for UPS/MFH, 51.8% [95%CI: 29.8‐73.8%] for LMS, and 72.2% [95%CI: 45.1‐99.2%] for FS. Only UPS/MFH (n = 4) showed sarcoma‐related death >10 years. Multivariate analysis identified axial location (HR = 35.5, [95%CI: 3.4‐369.6]), high grade (HR = 16.9, [95%CI: 1.6‐185.1]), and disease relapse (HR = 485.1, [95%CI: 36.3‐6482.6]) as risk factors for death (p < 0.05). Treatment with chemotherapy (HR = 0.1, [95%CI: 0.01‐0.86]) and necrosis ≥85% (HR = 0.2, [95%CI: 0.04‐0.99]) showed improved survival (p < 0.05). NONE‐STS of bone has favorable long‐term survival similar to osteosarcoma. Patients receiving chemotherapy derive benefit in retrospective analyses. UPS/MFH histologies show sarcoma‐related death beyond 10 years. Further data on histologic subgroups are needed.
Endodontic management of a tooth with apical overfilling and perforating external root resorption: A case report
Authors: Sayyad Soufdoost Reza , Jamali Ghomi Ali , Labbaf Hossein 
Published: October 2020

AbstractSuccessful non‐surgical orthograde retreatment of a tooth with

external root resorption in apical third of root and overfilling material

beyond the apical barrier which was diagnosed with the help of cone beam

computed tomography (CBCT), was reported. Biodentine was used as the treatment

of choice for obturation of resorption area.
Operating Performance Assessment for Transition State of Industrial Processes
Authors: Li Ling , Wang Yalin , Sun Bei , Qian Yingcan 
Published: October 2020

AbstractTraditional operating performance assessment approaches mainly focus on the steady state. However, the assessment indicators designed for the steady state cannot be directly applied to the transition state. Moreover, identifying the process state for a multivariable system is difficult and time‐consuming. An operating performance assessment method for the transition state is developed. In the proposed framework, a transition state detection method is first proposed to detect the transition state from the data automatically and accurately. Then, a systematic set of several special indicators is developed based on the characteristic of the transition state. The effectiveness of the developed method is demonstrated with a case study of an industrial hydrocracking process.