bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-technical skills and otolaryngology: systematic review
Authors: Bannon R , Stewart K E , Bannister M 
Published: May 2020

AbstractObjectivesThis study aimed to assess the published literature on non-technical skills in otolaryngology surgery and examine the applicability of any research to others’ practice, and to explore how the published literature can identify areas for further development and guide future research.MethodsA systematic review was conducted using the following key words: ‘otolaryngology’, ‘otorhinolaryngology’, ‘ENT’, ‘ENT surgery’, ‘ear, nose and throat surgery’, ‘head and neck surgery’, ‘thyroid surgery’, ‘parathyroid surgery’, ‘otology’, ‘rhinology’, ‘laryngology’ ‘skull base surgery’, ‘airway surgery’, ‘non-technical skills’, ‘non technical skills for surgeons’, ‘NOTSS’, ‘behavioural markers’ and ‘behavioural assessment tool’.ResultsThree publications were included in the review – 1 randomised, controlled trial and 2 cohort studies – involving 78 participants. All were simulation-based studies involving training otolaryngology surgeons.ConclusionLittle research has been undertaken on non-technical skills in otolaryngology. Training surgeons’ non-technical skill levels are similar across every tested aspect. The research already performed can guide further studies, particularly amongst non-training otolaryngology surgeons and in both emergency and elective non-simulated environments.
The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China
Authors: Chen Min , Zhu Qiongmei , Xing Hui , Chen Huichao , Jin Xiaomei , Dong Lijuan , Dai Jie , Yang Min , Yang Cuiyun , Jia Manhong , Ma Yanling 
Published: May 2020

Abstract
HIV-1 drug resistance can compromise the effectiveness of antiretroviral therapy (ART). A survey of pretreatment HIV-1 drug resistance (PDR) was conducted in Lincang Prefecture of Yunnan Province. From 372 people living with HIV/AIDS initiating ART for the first time during 2017–2018, 322 pol sequences were obtained, of which 11 HIV-1 strain types were detected. CRF08_BC (70.2%, 226/322) was the predominant strain, followed by URF strains (10.6%, 34/322). Drug resistance mutations (DRMs) were detected among 34.2% (110/322) of the participants. E138A/G/K/R (14.3%, 46/322) and V179E/D/T (13.7%, 47/322) were the predominant DRMs. Specifically, E138 mutations commonly occurred in CRF08_BC (19.9%, 45/226). Among the DRMs detected, some independently conferred resistance, such as K65R (1.6%, 5/322), Y188C/F/L (0.9%, 3/322), K103N (0.6%, 2/322) and G190A (0.3%, 1/322), which conferred high-level resistance. The prevalence of PDR was 7.5% (95% CI: 4.6–10.3%) and the prevalence of non-nucleotide reverse transcriptase inhibitor (NNRTI) resistance was 5.0% (95% CI: 2.6–7.4%), which is below the threshold (⩾10%) of initiating a public health response. In conclusion, HIV-1 genetic diversity and an overall moderate level of PDR prevalence were found in western Yunnan. PDR surveillance should be continually performed to decide whether a public health response to NNRTI resistance should be initiated.
A person-centered approach to studying associations between psychosocial vulnerability factors and adolescent depressive symptoms and suicidal ideation in a Canadian longitudinal sample
Authors: Tisseyre Lalou , Lacourse Eric , Labelle Réal , Paquin Stéphane , Herba Catherine M. 
Published: May 2020

AbstractThis study used a person-centered approach to identify subgroups of adolescents who are at risk for depression and suicidal ideation. Latent class analysis was first applied to 1,290 adolescents from a Canadian cohort study in order to identify latent vulnerability subtypes based on 18 psychosocial vulnerability factors. Logistic regression analyses were conducted to study the associations between class membership and depressive symptoms and suicidal ideation 2 years later. The moderating role of sex in the associations between latent classes and depressive symptoms was explored. Five latent classes were identified: Low Vulnerability (42%), Substance Use Only (13%), Moderate Vulnerability (28%), Conduct Problems (8%) and High Vulnerability (9%). Compared with the Low Vulnerability class, the probabilities of presenting depressive symptoms were higher for the Substance Use Only class, OR = 1.93, 95% CI [1.21, 3.06], the Moderate Vulnerability class, OR = 2.96, 95% CI [2.09, 4.20], the Conduct Problems class, OR = 3.03, 95% CI [1.84, 4.98], and the High Vulnerability class, OR = 5.4, 95% CI [3.42, 8.53]. Furthermore, interaction effects with sex were identified in relation to depressive symptoms only. The probability of presenting suicidal ideation was higher only for the High Vulnerability class, OR = 4.51, 95% CI [2.41, 8.43]. This study highlights the importance of a person-centered perspective that considers both vulnerability subtypes and sex because these associations are complex rather than linear or additive.
A cultural adaptation and validation of a child eating behaviour measure in a low- and middle-income country
Authors: Purwaningrum DN , Arcot J , Hadi H , Hasnawati RA , Rahmita RS , Jayasuriya R 
Published: May 2020

AbstractObjective:The Child Eating Behaviour Questionnaire (CEBQ), a widely used instrument that has been validated mostly in high-income countries, has limitations in its factorial validity when used among different cultures. This study examines whether the CEBQ instrument is culturally appropriate and valid to be used in a low- and middle-income country (LMIC) in a setting where child undernutrition remains prevalent.Design:The study employed a qualitative process to validate the content of items relative to the culture and setting, which was followed by a survey to test the psychometric properties of the instrument. Tests of factorial validity, convergent validity and reliability were performed.Setting:Three different socio-economic settings of Yogyakarta, Indonesia.Participants:The participants of this study were mothers of children aged 25–60 months. In-depth interviews were conducted with twenty-four mothers and the questionnaire validation process involved 238 mothers in the survey.Results:A Confirmatory Factor Analysis model with eight subscales provided the best fit (root-mean-square error of approximation = 0·048 (90 % CI 0·040, 0·057); Comparative Fit Index = 0·95 and Tucker Lewis Index = 0·95) after three new items and eight items from the original CEBQ were removed. Convergent validity with child’s weight was found for two subscales, slowness in eating and satiety responsiveness. Reliability measured using Cronbach’s alpha provided values between 0·62 and 0·78.Conclusion:The original eight-factor structure of the CEBQ showed adequate content validity and provided factorial, discriminant and convergent validity with mothers of preschool children living in a LMIC where child nutrition remains a significant public health issue.
Maternal depression trajectories from 3 months to 11 years postpartum and offspring body composition in early adolescence
Authors: Farías-Antúnez Simone , Matijasevich Alicia , de Barros Aluísio Jardim Dornellas , Santos Iná da Silva dos 
Published: May 2020

AbstractObjective:To investigate the effect of maternal depressive symptom trajectories, from 3 months to 11 years postpartum, on the offspring’s body composition at 11 years of age.Design:Data from the Pelotas 2004 Birth Cohort, from the perinatal interview and from the 3-, 12-, 24- and 48-month and 6- and 11-year follow-ups.Setting:Community-based sample from the city of Pelotas, located in southern Brazil with approximately 350 000 inhabitants. The maternal depression symptom trajectories were identified through a semi-parametric group-based modelling approach, using the Edinburgh Postnatal Depression Scale (EPDS), with data from 3 months to 11 years postpartum.Participants:A total of 3467 (81·9 % of the total cohort).Results:Five trajectory groups of EPDS scores were identified (‘Low’, ‘Moderate low’, ‘Increasing’, ‘Decreasing’ and ‘Chronic high’). A total of 170 women (4·9 %) from the sample belonged to the ‘Chronic high’ group, having scored ≥13 EPDS points at every follow-up. Mean BMI in the ‘Low’ trajectory group was 0·77 (z-score 1·4), compared with 0·56 (z-score 1·4) in the ‘Chronic high’ group. Children from mothers in the ‘Chronic high’ group had lower fat mass (FM) (–1·34 ± 0·64 kg), FM% (–2·02 ± 0·85 percentage points) and FM index (–0·57 ± 0·27 kg/m2), compared with children from mothers in the ‘Low’ trajectory group. Adjusted analyses showed that sustained or transitory maternal depressive symptoms during childhood had no effect on the offspring’s body composition indices at 11 years of age.Conclusion:Children raised by chronically depressed mothers have body composition indices at 11 years of age that are similar to those of children whose mothers have never been depressed.
Discovery of Mega‐Sheath Folds Flooring the Liwan Subbasin (South China Sea): Implications for the Rheology of Hyperextended Crust
Authors: Zhang C. , Manatschal G. , Pang X. , Sun Z. , Zheng J. , Li H. , Sun L. , Zhang J. , Zhao Y. 
Published: May 2020

AbstractSheath folds recognized on kilometer scale are rare and only described in salt tectonics in seismic data. Here, we present mega‐sheath folds spectacularly imaged in a 3‐D seismic survey in the seismic basement flooring the hyperextended Liwan subbasin in the northern margin of the South China Sea. The sheath folds show eye structures delimited by anastomosing discontinuities. The axial planes of the sheath folds are subparallel to a rift‐related, extensional detachment surface separating hyperextended seismic basement from the syn‐rift sedimentary sequence. The sheath folds as well as the anastomosing discontinuities formed during hyperextension by ductile shearing of the forearc inherited and prestructured metasediments. The ductile shearing eventually resulted in the metasediments derived from midcrust unroofed at the footwall of an extension detachment fault. The discovery of mega‐sheath folds and ductile deformation within the basement conflicts with the general assumption that hyperextended domains are in the brittle field. The new seismic observations show the importance of forearc inherited, prestructured anisotropic basement controlling the crustal rheology during hyperextension.
A First Look at Cloud Inhomogeneity and Its Effect on Lightning Optical Emission
Authors: Brunner Kelcy N. , Bitzer Phillip M. 
Published: May 2020

AbstractOptical emission observed from lightning is the result of in‐cloud scattering, lightning channel geometry, and optical energy of the source discharge. To better understand how scattering affects measured optical emission, we developed a Monte Carlo model using an inhomogeneous scattering profile from a simulated storm using two‐moment bulk microphysics in the Weather Research and Forecasting model, including the concentration and size distribution of cloud droplets and ice particles. Within the Monte Carlo model lightning discharges are simulated as point and line sources. These idealized simulations indicate that for a lightning discharge at 7 km altitude approximately 22% and 13% of light, emitted near and away (respectively) from a reflectivity core will reach cloud top in a thunderstorm. The vertical gradient of the microphysical environment impacts light reaching cloud top regardless of overall particle concentration. Increasing cloud ice modifies the gradient of the microphysical profile and modulates the profile gradient effect.
High‐Fidelity Archeointensity Results for the Late Neolithic Period From Central China
Authors: Cai Shuhui , Tauxe Lisa , Wang Weilin , Deng Chenglong , Pan Yongxin , Yang Liping , Qin Huafeng 
Published: May 2020

AbstractArcheomagnetism focuses on exploring high‐resolution variations of the geomagnetic field over hundreds to thousands of years. In this study, we carried out a comprehensive study of chronology, absolute and relative paleointensity on a late Neolithic site in central China. Ages of the samples are constrained to be ~3,500–3,000 BCE, a period when available paleointensity data are sparse. We present a total of 64 high‐fidelity absolute paleointensities, demonstrating the field varied quickly from ~55 to ~90 ZAm2 between ~3,500–3,000 BCE. Our results record a new archeomagnetic jerk around 3,300 BCE, which is probably non‐dipolar origin. The new results provide robust constraints on global geomagnetic models. We calculated a revised Chinese archeointensity reference curve for future application. The variations of absolute and relative paleointensity versus depth show good consistency, reinforcing the reliability of our results. This new attempt of combining absolute and relative paleointenstiy provides a useful tool for future archeomagnetic research.
Revised Estimates of Ocean Surface Drag in Strong Winds
Authors: Curcic M. , Haus B. K. 
Published: May 2020

AbstractAir‐sea drag governs the momentum transfer between the atmosphere and the ocean and remains largely unknown in hurricane winds. We revisit the momentum budget and eddy covariance methods to estimate the surface drag coefficient in the laboratory. Our drag estimates agree with field measurements in low‐to‐moderate winds and previous laboratory measurements in hurricane‐force winds. The drag coefficient saturates at 2.6×10−3 and U10≈25 m s−1, in agreement with previous laboratory results by Takagaki et al. (2012,). During our analysis, we discovered an error in the original source code used by Donelan et al. (2004,). We present the corrected data and describe the correction procedure. Although the correction to the data does not change the key finding of drag saturation in strong winds, its magnitude and wind speed threshold are significantly changed. Our findings emphasize the need for an updated and unified drag parameterization based on field and laboratory data.
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice
Authors: Wang ShengPeng , Cao Shuang , Arhatte Malika , Li Dahui , Shi Yue , Kurz Sabrina , Hu Jiong , Wang Lei , Shao Jingchen , Atzberger Ann , Wang Zheng , Wang Changhe , Zang Weijin , Fleming Ingrid , Wettschureck Nina , Honoré Eric , Offermanns Stefan 
Published: May 2020

AbstractWhite adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis). Adipogenesis results in WAT hyperplasia, smaller adipocytes and a metabolically more favourable form of obesity. How obesogenic WAT hyperplasia is induced remains, however, poorly understood. Here, we show that the mechanosensitive cationic channel Piezo1 mediates diet-induced adipogenesis. Mice lacking Piezo1 in mature adipocytes demonstrated defective differentiation of preadipocyte into mature adipocytes when fed a high fat diet (HFD) resulting in larger adipocytes, increased WAT inflammation and reduced insulin sensitivity. Opening of Piezo1 in mature adipocytes causes the release of the adipogenic fibroblast growth factor 1 (FGF1), which induces adipocyte precursor differentiation through activation of the FGF-receptor-1. These data identify a central feed-back mechanism by which mature adipocytes control adipogenesis during the development of obesity and suggest Piezo1-mediated adipocyte mechano-signalling as a mechanism to modulate obesity and its metabolic consequences.
Piezoelectricity and topological quantum phase transitions in two-dimensional spin-orbit coupled crystals with time-reversal symmetry
Authors: Yu Jiabin , Liu Chao-Xing 
Published: May 2020

AbstractFinding new physical responses that signal topological quantum phase transitions is of both theoretical and experimental importance. Here, we demonstrate that the piezoelectric response can change discontinuously across a topological quantum phase transition in two-dimensional time-reversal invariant systems with spin-orbit coupling, thus serving as a direct probe of the transition. We study all gap closing cases for all 7 plane groups that allow non-vanishing piezoelectricity, and find that any gap closing with 1 fine-tuning parameter between two gapped states changes either the Z2 invariant or the locally stable valley Chern number. The jump of the piezoelectric response is found to exist for all these transitions, and we propose the HgTe/CdTe quantum well and BaMnSb2 as two potential experimental platforms. Our work provides a general theoretical framework to classify topological quantum phase transitions, and reveals their ubiquitous relation to the piezoelectric response.
Ancillary ligand increases the efficiency of heteroleptic Ir-based triplet emitters in OLED devices
Authors: Baek Seung-yeol , Kwak Seung-Yeon , Kim Seoung-Tae , Hwang Kyu Young , Koo Hyun , Son Won-Joon , Choi Byoungki , Kim Sunghan , Choi Hyeonho , Baik Mu-Hyun 
Published: May 2020

AbstractThe excellent contrast ratio, visibility, and advantages in producing thin and light displays let organic light emitting diodes change the paradigm of the display industry. To improve future display technologies, higher electroluminescence efficiency is needed. Herein, the detailed study of the non-radiative decay mechanism employing density functional theory calculations is carried out and a simple, general strategy for the design of the ancillary ligand is formulated. It is shown that steric bulk properly directed towards the phenylisoquinoline ligands can significantly reduce the non-radiative decay rate.
Regulated repression governs the cell fate promoter controlling yeast meiosis
Authors: Tam Janis , van Werven Folkert J. 
Published: May 2020

AbstractIntrinsic signals and external cues from the environment drive cell fate decisions. In budding yeast, the decision to enter meiosis is controlled by nutrient and mating-type signals that regulate expression of the master transcription factor for meiotic entry, IME1. How nutrient signals control IME1 expression remains poorly understood. Here, we show that IME1 transcription is regulated by multiple sequence-specific transcription factors (TFs) that mediate association of Tup1-Cyc8 co-repressor to its promoter. We find that at least eight TFs bind the IME1 promoter when nutrients are ample. Remarkably, association of these TFs is highly regulated by different nutrient cues. Mutant cells lacking three TFs (Sok2/Phd1/Yap6) displayed reduced Tup1-Cyc8 association, increased IME1 expression, and earlier onset of meiosis. Our data demonstrate that the promoter of a master regulator is primed for rapid activation while repression by multiple TFs mediating Tup1-Cyc8 recruitment dictates the fate decision to enter meiosis.
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
Authors: Zhang Wei , Ji Tianjiao , Li Yang , Zheng Yueqin , Mehta Manisha , Zhao Chao , Liu Andong , Kohane Daniel S. 
Published: May 2020

AbstractAn on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable. Here, we design and synthesize a macromolecular prodrug (P407-CM-T) in which the local anesthetic tetracaine (T) is attached to the polymer poloxamer 407 (P407) via a photo-cleavable coumarin linkage (CM). P407-CM-T solution is an injectable liquid at room temperature and gels near body temperature. The macromolecular prodrug has no anesthetic effect itself unless irradiated with a low-power blue light emitting diode (LED), resulting in local anesthesia. By adjusting the intensity and duration of irradiation, the anesthetic effect can be modulated. Local anesthesia can be repeatedly triggered.
Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution
Authors: Shingate Prashant , Ravi Vydianathan , Prasad Aravind , Tay Boon-Hui , Garg Kritika M. , Chattopadhyay Balaji , Yap Laura-Marie , Rheindt Frank E. , Venkatesh Byrappa 
Published: May 2020

AbstractThe evolutionary history of horseshoe crabs, spanning approximately 500 million years, is characterized by remarkable morphological stasis and a low species diversity with only four extant species. Here we report a chromosome-level genome assembly for the mangrove horseshoe crab (Carcinoscorpius rotundicauda) using PacBio reads and Hi-C data. The assembly spans 1.67 Gb with contig N50 of 7.8 Mb and 98% of the genome assigned to 16 chromosomes. The genome contains five Hox clusters with 34 Hox genes, the highest number reported in any invertebrate. Detailed analysis of the genome provides evidence that suggests three rounds of whole-genome duplication (WGD), raising questions about the relationship between WGD and species radiation. Several gene families, particularly those involved in innate immunity, have undergone extensive tandem duplication. These expanded gene families may be important components of the innate immune system of horseshoe crabs, whose amebocyte lysate is a sensitive agent for detecting endotoxin contamination.
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
Authors: Yu Li , Zhang Bin , Deochand Dinesh , Sacta Maria A. , Coppo Maddalena , Shang Yingli , Guo Ziyi , Zeng Xiaomin , Rollins David A. , Tharmalingam Bowranigan , Li Rong , Chinenov Yurii , Rogatsky Inez , Hu Xiaoyu 
Published: May 2020

AbstractStudies on macrophage gene expression have historically focused on events leading to RNA polymerase II recruitment and transcription initiation, whereas the contribution of post-initiation steps to macrophage activation remains poorly understood. Here, we report that widespread promoter-proximal RNA polymerase II pausing in resting macrophages is marked by co-localization of the negative elongation factor (NELF) complex and facilitated by PU.1. Upon inflammatory stimulation, over 60% of activated transcriptome is regulated by polymerase pause-release and a transient genome-wide NELF dissociation from chromatin, unexpectedly, independent of CDK9, a presumed NELF kinase. Genetic disruption of NELF in macrophages enhanced transcription of AP-1-encoding Fos and Jun and, consequently, AP-1 targets including Il10. Augmented expression of IL-10, a critical anti-inflammatory cytokine, in turn, attenuated production of pro-inflammatory mediators and, ultimately, macrophage-mediated inflammation in vivo. Together, these findings establish a previously unappreciated role of NELF in constraining transcription of inflammation inhibitors thereby enabling inflammatory macrophage activation.