bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial
Authors: Bellgardt Martin , Georgevici Adrian Iustin , Klutzny Mitja , Drees Dominik , Meiser Andreas , Gude Philipp , Vogelsang Heike , Weber Thomas Peter , Herzog-Niescery Jennifer 
Published: October 2019

Abstract
Background
The MIRUS™ (TIM, Koblenz, Germany) is an electronical gas delivery system, which offers an automated MAC (minimal alveolar concentration)-driven application of isoflurane, sevoflurane, or desflurane, and can be used for sedation in the intensive care unit. We investigated its consumption of volatile anesthetics at 0.5 MAC (primary endpoint) and the corresponding costs. Secondary endpoints were the technical feasibility to reach and control the MAC automatically, the depth of sedation at 0.5 MAC, and awakening times. Mechanically ventilated and sedated patients after major surgery were enrolled. Upon arrival in the intensive care unit, patients obtained intravenous propofol sedation for at least 1 h to collect ventilation and blood gas parameters, before they were switched to inhalational sedation using MIRUS™ with isoflurane, sevoflurane, or desflurane. After a minimum of 2 h, inhalational sedation was stopped, and awakening times were recorded. A multivariate electroencephalogram and the Richmond Agitation Sedation Scale (RASS) were used to assess the depth of sedation. Vital signs, ventilation parameters, gas consumption, MAC, and expiratory gas concentrations were continuously recorded.

Results
Thirty patients obtained inhalational sedation for 18:08 [14:46–21:34] [median 1st–3rd quartiles] hours. The MAC was 0.58 [0.50–0.64], resulting in a Narcotrend Index of 37.1 [30.9–42.4] and a RASS of − 3.0 [− 4.0 to (− 3.0)]. The median gas consumption was significantly lowest for isoflurane ([ml h−1]: isoflurane: 3.97 [3.61–5.70]; sevoflurane: 8.91 [6.32–13.76]; and desflurane: 25.88 [20.38–30.82]; p < 0.001). This corresponds to average costs of 0.39 € h−1 for isoflurane, 2.14 € h−1 for sevoflurane, and 7.54 € h−1 for desflurane. Awakening times (eye opening [min]: isoflurane: 9:48 [4:15–20:18]; sevoflurane: 3:45 [0:30–6:30]; desflurane: 2:00 [1:00–6:30]; p = 0.043) and time to extubation ([min]: isoflurane: 10:10 [8:00–20:30]; sevoflurane: 7:30 [4:37–14:22]; desflurane: 3:00 [3:00–6:00]; p = 0.007) were significantly shortest for desflurane.

Conclusions
A target-controlled, MAC-driven automated application of volatile anesthetics is technically feasible and enables an adequate depth of sedation. Gas consumption was highest for desflurane, which is also the most expensive volatile anesthetic. Although awakening times were shortest, the actual time saving of a few minutes might be negligible for most patients in the intensive care unit. Thus, using desflurane seems not rational from an economic perspective.
Trial registration Clinical Trials Registry (ref.: NCT03860129). Registered 24 September 2018—Retrospectively registered.
Link prediction in paper citation network to construct paper correlation graph
Authors: Liu Hanwen , Kou Huaizhen , Yan Chao , Qi Lianyong 
Published: October 2019

Abstract
Nowadays, recommender system has become one of the main tools to search for users’ interested papers. Since one paper often contains only a part of keywords that a user is interested in, recommender system returns a set of papers that satisfy the user’s need of keywords. Besides, to satisfy the users’ requirements of further research on a certain domain, the recommended papers must be correlated. However, each paper of an existing paper citation network hardly has cited relationships with others, so the correlated links among papers are very sparse. In addition, while a mass of research approaches have been put forward in terms of link prediction to address the network sparsity problems, these approaches have no relationship with the effect of self-citations and the potential correlations among papers (i.e., these correlated relationships are not included in the paper citation network as their published time is close). Therefore, we propose a link prediction approach that combines time, keywords, and authors’ information and optimizes the existing paper citation network. Finally, a number of experiments are performed on the real-world Hep-Th datasets. The experimental results demonstrate the feasibility of our proposal and achieve good performance.
A comparison between two recommendations to conduct and report systematic reviews on drug’s safety
Authors: Penedones Ana , Alves Carlos , Batel Marques Francisco 
Published: October 2019

AbstractBackgroundSeveral recommendations are available to conduct and report a systematic review of adverse drug reactions. This study is aimed at identifying and comparing the methodologies of the two most commonly used recommendations to conduct and report systematic reviews on drug’s safety.MethodsTwo systematic reviews were conducted following the recommendations “Cochrane Handbook for Systematic Reviews of Interventions” and “Systematic Reviews’ Centre for Reviews and Dissemination guidance for undertaking reviews in healthcare.” The methods of each recommendation were characterized, and the results and the discussion of each systematic review were also evaluated.ResultsThe methodologies of both recommendations are similar. The review question was structured. Both recommendations suggest to include pre- and post-marketing data. The recommended data sources differed and, consequently, the results of the systematic reviews (37 vs. 35 studies). Other aspects of search literature were identical. Different tools are suggested to evaluate the methodological quality of the included studies. For case reports, both recommendations only report some questions that may be helpful to assess risk of bias. The reporting of the results and discussion is also identical for both recommendations.ConclusionsFew methodological differences were observed between the analyzed recommendations to conduct a systematic review on drug’s safety. Combining their methods into a single and recognized recommendation could be of great value.
Existence and exponential stability in the pth moment for impulsive neutral stochastic integro-differential equations driven by mixed fractional Brownian motion
Authors: Zhou Xia , Zhou Dongpeng , Zhong Shouming 
Published: October 2019

Abstract
This paper consider the existence, uniqueness and exponential stability in the pth moment of mild solution for impulsive neutral stochastic integro-differential equations driven simultaneously by fractional Brownian motion and by standard Brownian motion. Based on semigroup theory, the sufficient conditions to ensure the existence and uniqueness of mild solutions are obtained in terms of fractional power of operators and Banach fixed point theorem. Moreover, the pth moment exponential stability conditions of the equation are obtained by means of an impulsive integral inequality. Finally, an example is presented to illustrate the effectiveness of the obtained results.
A note on singular integrals with angular integrability
Authors: Liu Feng 
Published: October 2019

Abstract
In this note we study the rough singular integral
$$ T_{\varOmega }f(x)=\mathrm{p.v.} \int _{\mathbb{R}^{n}}f(x-y)\frac{\varOmega (y/ \vert y \vert )}{ \vert y \vert ^{n}}\,dy, $$

T
Ω

f
(
x
)
=

p
.
v
.

∫

R
n

f
(
x
−
y
)

Ω
(
y
/
|
y
|
)

|
y

|
n

d
y
,
where $n\geq 2$
n
≥
2
and Ω is a function in $L\log L(\mathrm{S} ^{n-1})$
L
log
L
(

S

n
−
1

)
with vanishing integral. We prove that $T_{\varOmega }$

T
Ω

is bounded on the mixed radial-angular spaces $L_{|x|}^{p}L_{\theta }^{\tilde{p}}( \mathbb{R}^{n})$

L

|
x
|

p

L
θ

p
˜

(

R
n

)
, on the vector-valued mixed radial-angular spaces $L_{|x|}^{p}L_{\theta }^{\tilde{p}}(\mathbb{R}^{n},\ell ^{\tilde{p}})$

L

|
x
|

p

L
θ

p
˜

(

R
n

,

ℓ

p
˜

)
and on the vector-valued function spaces $L^{p}(\mathbb{R}^{n}, \ell ^{\tilde{p}})$

L
p

(

R
n

,

ℓ

p
˜

)
if $1<\tilde{p}\leq p<\tilde{p}n/(n-1)$
1
<

p
˜

≤
p
<

p
˜

n
/
(
n
−
1
)
or $\tilde{p}n/(\tilde{p}+n-1)< p\leq \tilde{p}<\infty $

p
˜

n
/
(

p
˜

+
n
−
1
)
<
p
≤

p
˜

<
∞
. The same conclusions hold for the well-known Riesz transforms and directional Hilbert transforms. It should be pointed out that our proof is based on the Calderón–Zygmund’s rotation method.
Further results on the asymptotic stability of Riemann–Liouville fractional neutral systems with variable delays
Authors: Altun Yener 
Published: October 2019

Abstract
In this paper, the investigation of the asymptotic stability of Riemann–Liouville fractional neutral systems with variable delays has been presented. The advantage of the Lyapunov functional was used to achieve the desired results. The stability criteria obtained for zero solution of the system were formulated as linear matrix inequalities (LMIs) which can be easily solved. The advantage of the considered method is that the integer-order derivatives of the Lyapunov functionals can be directly calculated. Finally, three numerical examples have been evaluated to illustrate that the proposed method is flexible and efficient in terms of computation and to demonstrate the feasibility of established assumptions by MATLAB-Simulink.
Stability analysis of a nonlinear coupled implicit switched singular fractional differential system with p-Laplacian
Authors: Ahmad Manzoor , Zada Akbar , Alzabut Jehad 
Published: October 2019

AbstractThis paper deals with existence, uniqueness, and Hyers–Ulam stability of solutions to a nonlinear coupled implicit switched singular fractional differential system involving Laplace operator$\phi _{p}$ϕp. The proposed problem consists of two kinds of fractional derivatives, that is, Riemann–Liouville fractional derivative of orderβand Caputo fractional derivative of orderσ, where$m-1<\beta $m−1<β,$\sigma < m$σ<m,$m\in \{2,3,\dots \}$m∈{2,3,…}. Prior to proceeding to the main results, the system is converted into an equivalent integral form by the help of Green’s function. Using Schauder’s fixed point theorem and Banach’s contraction principle, the existence and uniqueness of solutions are proved. The main results are demonstrated by an example.
On applications of Caputo k-fractional derivatives
Authors: Farid Ghulam , Latif Naveed , Anwar Matloob , Imran Ali , Ozair Muhammad , Nawaz Madeeha 
Published: October 2019

Abstract
This research explores Caputo k-fractional integral inequalities for functions whose nth order derivatives are absolutely continuous and possess Grüss type variable bounds. Using Chebyshev inequality (Waheed et al. in IEEE Access 7:32137–32145, 2019) for Caputo k-fractional derivatives, several integral inequalities are derived. Further, Laplace transform of Caputo k-fractional derivative is presented and Caputo k-fractional derivative and Riemann–Liouville k-fractional integral of an extended generalized Mittag-Leffler function are calculated. Moreover, using the extended generalized Mittag-Leffler function, Caputo k-fractional differential equations are presented and their solutions are proposed by applying the Laplace transform technique.
The infectious thyroid nodule: A case report of mucormycosis associated with ibrutinib therapy
Authors: Mascarella Marco A. , Schweitzer Lorne , Alreefi Mahmoud , Silver Jennifer , Caglar Derin , Loo Vivian G. , Richardson Keith , Dufresne Philippe , Lee Todd C. , Sadeghi Nader 
Published: October 2019

Background Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. Case presentation We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. Conclusion Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.
Combined Micro- and Macro scale X-ray powder diffraction mapping of degraded Orpiment paint in a 17th century still life painting by Martinus Nellius
Authors: Simoen Jonas , De Meyer Steven , Vanmeert Frederik , de Keyser Nouchka , Avranovich Ermanno , Van der Snickt Geert , Van Loon Annelies , Keune Katrien , Janssens Koen 
Published: October 2019

Abstract
The spontaneous chemical alteration of artists’ pigment materials may be caused by several degradation processes. Some of these are well known while others are still in need of more detailed investigation and documentation. These changes often become apparent as color modifications, either caused by a change in the oxidation state in the original material or the formation of degradation products or salts, via simple or more complex, multistep reactions. Arsenic-based pigments such as orpiment (As2S3) or realgar (α-As4S4) are prone to such alterations and are often described as easily oxidizing upon exposure to light. Macroscopic X-ray powder diffraction (MA-XRPD) imaging on a sub area of a still life painting by the 17th century Dutch painter Martinus Nellius was employed in combination with microscopic (μ-) XRPD imaging of a paint cross section taken in the area imaged by MA-XRPD. In this way, the in situ formation of secondary metal arsenate and sulfate species and their migration through the paint layer stack they originate from could be visualized. In the areas originally painted with orpiment, it could be shown that several secondary minerals such as schultenite (PbHAsO4), mimetite (Pb5(AsO4)3Cl), palmierite (K2Pb(SO4)2) and syngenite (K2Ca(SO4)2∙H2O) have formed. Closer inspection of the cross-sectioned paint layer stack with μ-XRPD illustrates that the arsenate minerals schultenite and mimetite have precipitated at the interface between the orpiment layer and the layer below that is rich in lead white, i.e. close to the depth of formation of the arsenate ions. The sulfate palmierite has mostly precipitated at the surface and upper layers of the painting.
Challenges constraining availability and affordability of insulin in Bengaluru region (Karnataka, India): evidence from a mixed-methods study
Authors: Satheesh Gautam , Unnikrishnan M. K. , Sharma Abhishek 
Published: October 2019

Abstract

Introduction
Considering limited global access to affordable insulin, we evaluated insulin access in public and private health sectors in Bengaluru, India.

Methods
Employing modified WHO/HAI methodology, we used mixed-methods analysis to study insulin access and factors influencing insulin supply and demand in Bengaluru in December 2017. We assessed insulin availability, price and affordability in a representative sample of 5 public-sector hospitals, 5 private-sector hospitals and 30 retail pharmacies. We obtained insulin price data from websites of government Jan Aushadhi scheme (JAS) and four online private-sector retail pharmacies. We interviewed wholesalers in April 2018 to understand insulin market dynamics.

Results
Mean availability of insulins on India’s 2015 Essential Medicine List was 66.7% in the public sector, lower than private-sector retail (76.1%) and hospital pharmacies (93.3%). Among private retailers, mean availability was higher among chain (96.7%) than independent pharmacies (68.3%). Non-Indian companies supplied 67.3% products in both sectors. 79.1% products were manufactured in India, of which 60% were marketed by non-Indian companies.
In private retail pharmacies, median consumer prices of human insulin cartridges and pens were 2.5 and 3.6 times, respectively, that of human insulin vials. Analogues depending on delivery device were twice as expensive as human insulin. Human insulin vials were 18.3% less expensive in JAS pharmacies than private retail pharmacies. The lowest paid unskilled worker would pay 1.4 to 9.3 days’ wages for a month’s supply, depending on insulin type and health sector. Wholesaler interviews suggest that challenges constraining patient insulin access include limited market competition, physicians' preference for non-Indian insulins, and the ongoing transition from human to analogue insulin. Rising popularity of online and chain pharmacies may influence insulin access.

Conclusion
Insulin availability in Bengaluru’s public sector falls short of WHO’s 80% target. Insulin remains unaffordable in both private and public sectors. To improve insulin availability and affordability, government should streamline insulin procurement and supply chains at different levels, mandate biosimilar prescribing, educate physicians to pursue evidence-based prescribing, and empower pharmacists with brand substitution. Patients must be encouraged to shop around for lower prices from subsidized schemes like JAS. While non-Indian companies dominate Bengaluru’s insulin market, rising market competition from Indian companies may improve access.
DEGREE OF INTENSITY in English-Chinese translation: a corpus-based approach
Authors: Li Long , Wu Canzhong 
Published: October 2019

AbstractThe claim in translation studies that Chinese tends to have a preference for stronger or more exaggerated terms than does English has not been substantiated by any hard linguistic evidence. One system to approach such perceived differences in intensity is degree of intensity (DOI), which is an important device of fine-tuning taken by a speaker to express interpersonal judgments. However, it has not been systematically studied, in quantitative terms, for the Chinese language, nor has a contrastive study been conducted between English and Chinese. This study aims to adopt a corpus-based approach and investigate the phenomenon, using the Chinese translation of a politically volatile English autobiography by a Chinese migrant writer, Wild Swans (Chang 1991), as the domain of study, and comparing it with another translation of this kind and against two reference corpora of non-translated texts (FLOB and LCMC). The findings of the research suggest that Chinese indeed prefers more and higher degrees of intensity, but they also show that translator’s choice-making plays an important role in the translation of degree of intensity.
CT radiomic features for predicting resectability of oesophageal squamous cell carcinoma as given by feature analysis: a case control study
Authors: Ou Jing , Li Rui , Zeng Rui , Wu Chang-qiang , Chen Yong , Chen Tian-wu , Zhang Xiao-ming , Wu Lan , Jiang Yu , Yang Jian-qiong , Cao Jin-ming , Tang Sun , Tang Meng-jie , Hu Jiani 
Published: October 2019

Abstract

Background
Computed tomography (CT) is commonly used in all stages of oesophageal squamous cell carcinoma (SCC) management. Compared to basic CT features, CT radiomic features can objectively obtain more information about intratumour heterogeneity. Although CT radiomics has been proved useful for predicting treatment response to chemoradiotherapy in oesophageal cancer, the best way to use CT radiomic biomarkers as predictive markers for determining resectability of oesophageal SCC remains to be developed. This study aimed to develop CT radiomic features related to resectability of oesophageal SCC with five predictive models and to determine the most predictive model.

Methods
Five hundred ninety-one patients with oesophageal SCC undergoing contrast-enhanced CT were enrolled in this study, and were composed by 270 resectable cases and 321 unresectable cases. Of the 270 resectable oesophageal SCCs, 91 cases were primary resectable tumours; and the remained 179 cases received neoadjuvant therapy after CT, shrank on therapy, and changed to resectable tumours. Four hundred thirteen oesophageal SCCs including 189 resectable cancers and 224 unresectable cancers were randomly allocated to the training cohort; and 178 oesophageal SCCs including 81 resectable tumours and 97 unresectable tumours were allocated to the validation group. Four hundred ninety-five radiomic features were extracted from CT data for identifying resectability of oesophageal SCC. Useful radiomic features were generated by dimension reduction using least absolute shrinkage and selection operator. The optimal radiomic features were chosen using multivariable logistic regression, random forest, support vector machine, X-Gradient boost and decision tree classifiers. Discriminating performance was assessed with area under receiver operating characteristic curve (AUC), accuracy and F-1score.

Results
Eight radiomic features were selected to create radiomic models related to resectability of oesophageal SCC (P-values < 0.01 for both cohorts). Multivariable logistic regression model showed the best performance (AUC = 0.92 ± 0.04 and 0.87 ± 0.02, accuracy = 0.87 and 0.86, and F-1score = 0.93 and 0.86 in training and validation cohorts, respectively) in comparison with any other model (P-value < 0.001). Good calibration was observed for multivariable logistic regression model.

Conclusion
CT radiomic models could help predict resectability of oesophageal SCC, and multivariable logistic regression model is the most predictive model.
Efficacy of a bystander intervention for preventing dating violence in Brazilian adolescents: short-term evaluation
Authors: dos Santos Karine Brito , Murta Sheila Giardini , do Amaral Vinha Luis Gustavo , de Deus Juliana Silva 
Published: October 2019

AbstractPeers are the preferred source of help for Brazilian adolescents who experience dating violence. However, they are not always the best informants for effective responses for dealing with situations of violence in romantic relationships among peers. This experimental study aimed to evaluate the short-term efficacy of three aspects of a peer- and bystander approach-based intervention: the intent to offer help, empathy, and bystander attitudes in response to dating violence in a Brazilian sample of adolescents. The study’s participants were 33 adolescents randomized in two groups: experimental group (EG,n = 14) and control group (CG,n = 19). The EG underwent three weekly intervention sessions of 90 min each on the healthy versus violent romantic relationships, the quality of friendship in the peer network, and the role of the bystander, while the CG received no intervention. Evaluations were performed 1 week before and two and half months after the intervention. Statistically significant differences between EG and CG at post-test were not found in intention to help, empathy, and bystander attitudes. Future studies should include evaluations of larger samples and mid- and long-term follow-ups to identify patterns of change over the long term as well as examine barriers to utilization of bystander behaviors by adolescents in Brazilian culture.