bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAPAROSCOPIC RESECTIONS WITH TRANSANAL SPECIMEN EXTRACTION IN RECTAL CANCER SURGERY (a systematic review and meta-analysis)
Authors: Chernyshov S. V. , Sychev S. I. , Ponomarenko A. A. , Rybakov E. G. 
Published: December 2020

INTRODUCTION: the NOSES technique allows one to remove specimen without incisions on the anterior abdominal wall and is accompanied by fewer complications by reducing the frequency of wound infections. The results of these surgical operations on colorectal tumors are presented in a limited number of heterogeneous studies, which necessitates obtaining objective data using metaanalysis.STUDY OBJECTIVE: compare the short and long-term outcomes of two methods for surgical treatment of colorectal cancer.MATERIALS AND METHODS: a systematic review is carried out in accordance with PRISMA practice and recommendations.RESULTS: nine comparative studies were selected for the period from 2014 to 2019. 1693 patients were included in the meta-analysis: in 765 (45%), the tumor preparation was removed transanally (NOSES group) and in 928 (55%) it was removed via minilaparotomic access (LA group). The tumor size in the NOSES group was 0.5 cm smaller (OR=0.5, CI95% 0.2-0.8, p=0.0004) than in the LA group. In regards to other parameters the groups had no publication bias. The duration of the operation when comparing NOSES with LA was comparable (p =0.11). VAS pain was on average 2 points (OR=1.8, CI95% 1.2-2.4, p<0.00001) more pronounced in the LA group. The postoperative bed day was less in the group with transanal removal of the preparation (OR=0.8, CI95% 0.4-1.3, p=0.0003). The chance of developing postoperative complications in the NOSES group was (OR=0.5, CI95% 0.4-0.8, p=0.0004) with a frequency of 62/765 (8%) cases, compared with the control group - 130/931 (14%). The chance of developing wound infection was higher in the LA group (OR=0.2, CI95% 0.1-0.3, p <0.00001). There were no differences in the incidence of colorectal anastomotic leakage (p=0.97). There were also no differences in the five-year overall (p=0.74) and cancer-specific survival (p=0.76).CONCLUSION: using NOSES technologies creates better conditions for the rehabilitation of patients due to the low frequency of postoperative complications due to the absence of wound infection and is a safe manipulation. However, the presence of publication biases requires a careful interpretation of the data obtained.
Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation
Authors: Konkova Marina , Abramova Margarita , Kalianov Andrey , Ershova Elizaveta , Dolgikh Olga , Umriukhin Pavel , Izhevskaya Vera , Kutsev Sergey , Veiko Natalia , Kostyuk Svetlana 
Published: December 2020

IntroductionMesenchymal stem cells (MSCs) are applied as the therapeutic agents, e.g., in the tumor radiation therapy.Purpose of the StudyTo evaluate the human adipose MSC early response to low-dose ionizing radiation (LDIR).Materials and MethodsWe investigated different LDIR (3, 10, and 50 cGy) effects on reactive oxygen species production, DNA oxidation (marker 8-oxodG), and DNA breaks (marker ɣ H2AX) in the two lines of human adipose MSC. Using reverse transcriptase–polymerase chain reaction, fluorescence-activated cell sorting, and fluorescence microscopy, we determined expression of genes involved in the oxidative stress development (NOX4), antioxidative response (NRF2), antiapoptotic and proapoptotic response (BCL2, BCL2A1, BCL2L1, BIRC2, BIRC3, and BAX1), in the development of the nuclear DNA damage response (DDR) (BRCA1, BRCA2, ATM, and P53). Cell cycle changes were investigated by genes transcription changes (CCND1, CDKN2A, and CDKN1A) and using proliferation markers KI-67 and proliferating cell nuclear antigen (PCNA).ResultsFifteen to 120 min after exposure to LDIR in MSCs, transient oxidative stress and apoptosis of the most damaged cells against the background of the cell cycle arrest were induced. Simultaneously, DDR and an antiapoptotic response were found in other cells of the population. The 10-cGy dose causes the strongest and fastest DDR following cell nuclei DNA damage. The 3-cGy dose induces a less noticeable and prolonged response. The maximal low range dose, 50 cGy, causes a damaging effect on the MSCs.ConclusionTransient oxidative stress and the death of a small fraction of the damaged cells are essential components of the MSC population response to LDIR along with the development of DDR and antiapoptotic response. A scheme describing the early MSC response to LDIR is proposed.
Magnetostratigraphic Chronology of a Cenozoic Sequence From DSDP Site 274, Ross Sea, Antarctica
Authors: Jovane Luigi , Florindo Fabio , Wilson Gary , de Almeida Pecchiai Saldanha Leone Stephanie , Hassan Muhammad Bin , Rodelli Daniel , Cortese Giuseppe 
Published: December 2020

New paleomagnetic results from the late Eocene-Middle Miocene samples from Deep Sea Drilling Project Site 274, cored during Leg 28 on the continental rise off Victoria Land, Ross Sea, provide a chronostratigraphic framework for an existing paleoclimate archive during a key period of Antarctic climate and ice sheet evolution. Based on this new age model, the cored late Eocene-Middle Miocene sequence covers an interval of almost 20 Myr (from ∼35 to ∼15 Ma). Biostratigraphic constraints allow a number of possible correlations with the Geomagnetic Polarity Time Scale. Regardless of correlation, average interval sediment accumulation rates above 260 mbsf are ∼6 cm/kyr with the record punctuated by a number of unconformities. Below 260 mbsf (across the Eocene/Oligocene boundary) interval, sedimentation accumulation rates are closer to ∼1 cm/kyr. A major unconformity identified at ∼180 mbsf represents at least 9 Myr accounting for the late Oligocene and Early Miocene and represent non-deposition and/or erosion due to intensification of Antarctic Circumpolar Current activity. Significant fluctuations in grain size and magnetic properties observed above the unconformity at 180 mbsf, in the Early Miocene portion of this sedimentary record, reflect cyclical behavior in glacial advance and retreat from the continent. Similar glacial cyclicity has already been identified in other Miocene sequences recovered in drill cores from the Antarctic margin.
Synchronous and Metachronous Breast and Ovarian Cancer: Experience From Two Large Cancer Center
Authors: Tasca Giulia , Dieci Maria Vittoria , Baretta Zora , Faggioni Giovanni , Montagna Marco , Nicoletto Maria Ornella , Peccatori Fedro Alessandro , Guarneri Valentina , Colombo Nicoletta 
Published: December 2020

PurposeWe aimed to evaluate the clinico-pathological characteristics and survival outcomes of patients with synchronous or metachronous breast cancer (BC) and ovarian cancer (OC).Materials and MethodsPatients with synchronous or metachronous BC and OC were retrospectively identified at two large cancer centers. Clinico-pathological characteristics, BRCA1/2 status and follow-up data were gathered. Patients were classified according to the first cancer diagnosis in the following groups: Breast Cancer first, Ovarian Cancer first, Synchronous Breast and Ovarian Cancer. Overall survival (OS) was calculated as the time interval between each cancer diagnosis to death or last follow-up.ResultsOverall, 270 patients were included: n = 194 (72%) in BC first group, n = 51 (19%) in OC first, and n = 25 (9%) in synchronous. BRCA status was available for 182 (67.4%) patients and 112 (62%) harbored pathogenetic mutations. BC first group included more frequently patients with BRCA mutation, triple negative BC phenotype and more aggressive OC features. Median time between the two diagnosis was longer in BC first group vs OC first group (95 vs 68 months, p = 0.021). A total of 105 OS events occurred, mostly related to OC (70.5%). We observed no differences in terms of OS according to the first cancer diagnosis. Age &gt;50 years and advanced OC stage were negative independent prognostic factors for OS from the first diagnosis.ConclusionsIn this cohort of patients with BC and OC, survival was dominated by OC related mortality. These data may be useful to plan and carry out adequate and timely surveillance programs and preventive measures.
High-Pressure Supercritical CO2 Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway
Authors: Zhu Liping , Wu Min , Li Peng , Zhou Yanfei , Zhong Jinyi , Zhang Zhiqiang , Li Ye , Yao Weixi , Xu Jianhua 
Published: December 2020

As a noted medicinal mushroom, Ganoderma lucidum (G. lucidum) has been reported to have a number of pharmacological effects such as anti-tumor and liver protection. Compared with the common ethanol reflux method, supercritical CO2 extraction has obvious advantages in obtaining antitumor extracts from G. lucidum fruiting body such as short extraction time, low temperature and no solvent residue. However, Using high-pressure supercritical CO2 without entrainer to obtain the antitumor extracts from G. lucidum and studying their anti-hepatoma effect have not been reported. In this study, high-pressure supercritical CO2 extracts obtained under 65, 85, and 105 MPa pressure named as G65, G85, G105 respectively and ethanol reflux extract (GLE) were used to investigate their anti-hepatoma activity and the underlying molecular mechanism. The total triterpenoid content of G85 was significantly higher than that of G65 and GLE, but did not differ significantly from that of G105 by UV and high-performance liquid chromatography. GLE, G65, and G85 could inhibit cell proliferation, arrest cell cycle in G2/M phase, and induce apoptosis in two liver cancer cell lines (QGY7703 and SK-Hep1), of which G85 had the strongest effect. The results showed that the potency of their cytotoxicity of the high-pressure supercritical CO2 extracts on human hepatoma carcinoma cells in vitro was consistent with their total triterpenoid content. G85 exhibited significant anti-hepatoma effect with low toxicity In vivo. Further mechanistic investigation revealed that the anti-tumor effect of these extracts was associated with their inhibition of Ras/Raf/MEK/ERK signaling pathway. Our findings suggest that the high-pressure supercritical CO2 extraction of G. lucidum fruiting body can be used to obtain a triterpenoid-rich anti-tumor agent, which may have potential clinical significance for the treatment of human hepatoma.
O trabalho do/da Assistente Social na Assistência Estudantil
Authors: Medeiros do Nascimento Edna , Amélia Serpa Lopes de Souza Moema 
Published: December 2020

Este artigo apresenta reflexões sobre o trabalho do/a assistente social no universo da educação superior pública estadual, trazendo algumas aproximações sobre a inserção profissional do/a mesmo (a) na educação, as competências e atribuições profissionais nesse espaço sócio-cupacional e as implicações da seletividade da assistência estudantil para o trabalho profissional. A síntese de nossas reflexões aponta que a principal requisição profissional do/a assistente social nessas instituições consiste na realização de avaliação socioeconômica dos discentes, enfatizando a seletividade dos programas de permanência, constituindo-se, portanto, como um desafio para profissão no contexto de desmonte dos direitos sociais.
Intususcepción intestinal en la población pediátrica vs. población adulta
Authors: Hidalgo Mora Oscar Felipe , Martínez Daly Iraís Marina 
Published: December 2020

La intususcepción intestinal se define como la invaginación de un segmento del intestino en un segmento inmediatamente adyacente. Su forma más frecuente en la población pediátrica es la intususcepción idiopática de tipo ileocólica, la cual es considerada una de las urgencias abdominales más frecuentes. Ésta es tratada de manera general por medio de una reducción no quirúrgica, tal como un enema neumático y/o hidrostático. En la población adulta, por su parte, la presencia de intususcepción es poco común y ocurre con mayor frecuencia en el intestino delgado que en el colon. En la mayoría de los casos en esta población, la intususcepción se asocia con un punto pivote patológico que provoca la presencia de síntomas de obstrucción intestinal. Generalmente, la invaginación a nivel de intestino delgado tiene una etiología benigna, aunque cuando es maligna se asocia con mayor frecuencia a una enfermedad metastásica difusa. Por el contrario, la etiología maligna en la invaginación intestinal de tipo ileocólica y colónica se encuentra con mayor frecuencia asociada a un adenocarcinoma primario. De manera general, su diagnóstico se realiza de forma intraoperatoria o mediante imágenes transversales, tales como TAC o RMN del abdomen, permitiendo diagnosticar más fácilmente las intususcepciones asintomáticas y/o transitorias, las cuales pueden observarse adecuadamente sin ninguna intervención. Por su parte, en los casos que este justificada la intervención quirúrgica en la población adulta, se realiza una resección intestinal de tipo oncológico, esto debido a la frecuente asociación con malignidad de la intususcepción en dicho grupo de edad.
Pengaruh Penambahan Pasir Terhadap Daya Dukung Subgrade Jalan
Authors: Fardyansah Yudha , Gofar Nurly 
Published: December 2020

The performance of flexible pavement is highly influenced by the quality of subgrade material. In Palembang, the foundation soil is usually consisted of clay which is sensitive to change in water content caused by rainfall as well as inundation. This paper presents results of laboratory study on the effect of adding sand to clay to be used as subgrade material for urban roads. California Bearing Ratio (CBR) values were used as indication of strength improvement of the subgrade in unsoaked and soaked conditions. The suitability of the stabilized soil for use as subgrade of pavement construction in response to normal and inundated conditions was further assessed through field verification using Dynamic Cone Penetrometer. Results of both laboratory and field studies indicated that addition of 21% sand by dry weight give the most improvement in terms of CBR value. In this case, the CBR unsoaked increased from 8% to 18% while the CBR soaked increased from less than 3% to 8%. Field verification showed that the CBR of compacted natural soil decreased from 8% to 2% after rainfall while the CBR of the sand stabilized soil decreased from 17% to 8%. Thus the sand stabilized clay is expected to perform adequately even after subjected to rainfall and inundation.
RESIKO YURIDIS ASURANSI SOSIAL BAGI PEGAWAI PT TASPEN (PERSERO) KANTOR CABANG UTAMA SEMARANG YANG MENGAJUKAN PENSIUN DINI
Authors: Hafidh Rahmat , Andraini Fitika 
Published: December 2020

PT TASPEN (PERSERO) merupakan Badan Usaha Milik Negara Indonesia yang bergerak di bidang asuransi dana pensiun dan tabungan hari tua yang mengacu pada Peraturan Pemerintah Nomor 20 Tahun 2013 Tentang Perubahan Atas Peraturan Pemerintah Nomor 25 Tahun 1981 Tentang Asuransi Sosial Pegawai Negeri Sipil. PT TASPEN (PERSERO) dalam menjalankan perannya tidak selalu mampu memenuhi hak Pegawai Negeri atas hak pensiun dan tabungan hari tua karena adanya hal – hal yang diperlukan dalam pemenuhan atas hak pensiun dan tabungan hari tua. Hal – hal tersebut mengenai peran PT TASPEN (PERSERO) dalam menyelenggarakan program dana pensiun dan tabungan hari tua yang nantinya berhak menerima pesangon dan menerima hak – hak pensiun lainnya berdasarkan peraturan yang berlaku.
Permasalahan dalam penelitian ini mengenai resiko yuridis asuransi sosial bagi pegawai PT TASPEN (PERSERO) Kantor Cabang Utama Semarang yang mengajukan pensiun dini sebelum batas usia pensiun yang telah tentukan.
Penelitian ini, merupakan tipe penelitian yuridis normatif yaitu penelitian yang difokuskan untuk mengkaji penerapan kaidah – kaidah atau norma – norma dalam hukum positif.
Dari hasil penelitian ini menunjukkan bahwa, resiko yuridis saat pengajuan pensiun dini tidak ada akibat hukum kecuali orang yang bersangkutan bermasalah, pada saat pensiun akan mendapatkan sanksi administratif bisa berupa penundaan pensiun atau pesangon.
KEBIJAKAN PENGELOLAAN RETRIBUSI DAERAH OLEH PEMERINTAH KOTA SEMARANG TERHADAP PENEMPATAN PEDAGANG PASAR PETERONGAN.
Authors: Muzayanah Ilham Mohammad Ikhsan, 
Published: December 2020

Kewenangan Pemerintah dalam penarikan pajak dan retribusi dari masyarakat serta renovasi tidak hanya dimiliki oleh Pemerintah Pusat saja melainkan juga menjadi kewenangan Pemerintah Kota dan Pemerintah Propinsi. Hal ini sesuai dengan asas desentralisasi dan pelaksanaan otonomi daerah berdasarkan Undang- Undang Nomor 32 Tahun 2004 Tentang Pemerintahan Daerah, Undang-Undang Nomor 33 Tahun 2004 Tentang Perimbangan Keuangan Antara Pusat Dan Daerah, serta Undang-Undang Nomor 28 Tahun 2009 Tentang Pajak Daerah Dan Retribusi Daerah, Peraturan Daerah Kota Semarang Nomor 9 Tahun 2013 tetang Pengaturan Pasar Tradisional. Dalam rangka pengelolaan lingkungan pasar berupa pelayanan hukum kepada masyarakat di lingkungan pasar khususnya para pedagang, Pemerintah Kota Semarang telah mengeluarkan Peraturan Daerah Nomor 4 tahun 2004 tentang Retribusi Pasar. Penelitian ini mengangkat permasalahan yaitu: 1) Bagaimana pengelolaan retribusi daerah oleh pemerintah Kota Semarang, 2) Bagaimana kebijakan Kota Semarang terhadap renovasi Pasar Peterongan, 3) Bagaimana kebijakan Kota Semarang terhadap Pengaturan pedagang pasar Peterongan Kota Semarang setelah renovasi. Tujuan dari penulisan skripsi ini adalah 1) Untuk mengetahui dan menjelaskan pengelolaan retribusi daerah oleh Pemerintah Kota Semarang, 2) Untuk mengetahui dan menjelaskan kebijakan Kota Semarang terhadap renovasi Pasar Peterongan, 3) Untuk mengetahui dan menjelaskan pengaturan pedagang pasar Peterongan Kota Semarang setelah renovasi. Penelitian ini, adalah penelitian kualitatif dengan pendekatan yuridis normatif untuk mengetahui realisasi penerapan Peraturan Daerah Kota Semarang Nomor 4 tahun 2004 Tentang Retribusi Pasar dan Peraturan Daerah Kota Semarang Nomor 9 Tahun 2013 tetang Pengaturan Pasar Tradisional terhadap pedagang pasar. Penelitian ini di Pasar Peterongan Kota Semarang yang terletak di Jalan MT. Haryono. Hasil penelitian menunjukan bahwa Pemerintah Kota Semarang terhadap pedagang pasar sudah sesuai berdasarkan Peraturan Daerah Kota Semarang Nomor 4 tahun 2004 Tentang Retribusi Pasar dan Peraturan Daerah Kota Semarang Nomor 9 Tahun 2013 tentang Pengaturan Pasar Tradisional, Dengan beberapa hal yang masih merupakan catatan kepada pemerintah Kota Semarang untuk lebih memperhatikan keberlangsungan bagi kesejahteraan pedagang pasar tradisional, kondisi fisik dan lingkungan pasar.

Kata Kunci : Kebijakan, Pengelolaan Pasar Tradisional.
Kesetaraan Gender dalam Program Keluarga Berencana di Kecamatan Wabula Kabupaten Buton
Authors: Dausu La 
Published: December 2020

Tujuan penelitian ini adalah untuk mengkaji keterlibatan gender dalam program keluarga berencana. Wacana yang lazim terjadi bahwa terdapat perbedaan perilaku antara laki-laki dan perempuan, sehingga peran-peran strategis dalam program ini seringkali terjadi ketimpangan peran gender didalamnya.
Keluarga Berencana (KB) adalah upaya peningkatan kepedulian dan peran serta masyarakat melalui pendewasaan usia kawin, pengaturan jarak kelahiran, pembinaan keluarga, peningkatan kesejahteraan keluarga untuk mewujudkan keluarga kecil, bahagia dan sejahtera dengan memiliki dua anak lebih baik. Penelitian ini bertujuan Untuk mengetahui Bagaimana Kesetaraan Gender Dalam Program KB Di Kecamatan Wabula Kabupaten Buton. Penelitian yang digunakan adalah penelitian Deskriptif Kualitatif, dilakukan dengan cara pengamatan langsung dan diberikan daftar pertanyaan atau kuesioner dengan informan yang ditentukan oleh penulis. Kemudian, data yang ditemukan dari hasil wawancara dan pengamatan tersebut akan dianalisis secara Kualitatif. Populasi dalam penelitian ini yaitu Laki-Laki yang telah menikah yaitu sebanyak 15 orang. Teknik pengambilan sampel dengan menggunakan proportional random sampling atau pengambilan sampel secara acak. Teknik pengumpulan data yaitu :observasi, wawancara, studi kepustakaan dan Dokumentasi. Teknik Analisis Data menggunakan Microsoft Excell 2010. Hasil penelitian yaitu : Kurangnya partisipasi laki-laki dalam program KB, Tidak nyaman dalam memakai Kondom sebagai alat kontrasepsi dan Kurangnya pengetahuan tentang manfaat kondom
World Leadership Survey Biannual Report on Employee Commitment and Engagement 2013–2014
Authors: Deal Jennifer , Cullen Kristin , Stawiski Sarah , Gentry William , Ruderman Marian 
Published: December 2020

 From the Executive Summary: "The purpose of the World Leadership Survey (WLS) is to provide a window into how professionals, managers, and executives view their life within the organization. This view of the employee experience will help leaders of organizations understand what employees experience, and what the organization can do to improve commitment and reduce turnover. The good news for organizations in the United States and Canada (the sample for this report) is that respondents are mostly committed to their organizations, satisfied with their jobs and their pay, work more than the typical 40-hour workweek, and do not currently intend to leave their jobs. The professionals, managers, and executives surveyed feel supported by their organization and by their direct supervisor, and think that their organizations are economically stable. Unfortunately they also feel overloaded, with their work disproportionately interfering with the rest of life, and that there is a high level of political behavior within their organization. Both overload and overt political behavior can reduce individual and organizational effectiveness. This report describes the current employee experience, and what organizations can focus on to maintain and improve commitment and engagement.
Ironic Content Features in the Orthodox Media Discourse
Authors: Makarova Alexandra 
Published: December 2020

The religious communication is the most ancient of human communication
types. The pragmatic linguistics as well as rhetoric shows a special attitude
to this special type of discourse. Today the Internet text with its unlimited abilities
is being in the focus of linguists’ attention. That is why the orthodox journalists
are covering not only print media but also the Internet that helps to widen
the sphere of influence on the people’s minds and souls.
The analyses show that the media context of the Orthodox sites (such as
The Orthodox people laugh and etc.) includes humorous publications that prove
the necessity of studying peculiarities of religious communication and humorous
texts in orthodox sites. The integrative approach including content analyses,
discourse and linguistic cultural methods helps the author to come to a conclusion
that orthodox media texts are distinguished by intertextuality, hypertextuality, creolism, and the authors want to influence the addressee in the most effective way. To define the communicative task, the missionary function should be taken into account which is peculiar to the religious discourse.