bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cyclicality of Sales and Aggregate Price Flexibility
Authors: Kryvtsov Oleksiy , Vincent Nicolas 
Published: August 2020

AbstractMacroeconomists traditionally ignore temporary price markdowns (“sales”) under the assumption that they are unrelated to aggregate phenomena. We revisit this view. First, we provide robust evidence from the U.K. and U.S. CPI micro data that the frequency of sales is strongly countercyclical, as much as doubling during the Great Recession. Second, we build a general equilibrium model in which cyclical sales arise endogenously as retailers try to attract bargain hunters. The calibrated model fits well the business cycle co-movement of sales with consumption and hours worked, and the strong substitution between market work and shopping time documented in the time-use literature. The model predicts that after a monetary contraction, the heightened use of discounts by firms amplifies the fall in the aggregate price level, attenuating by a third the one-year response of real consumption.
FIELD ENHANCEMENT AND SIZE OF RADIO-FREQUENCY HOTSPOTS INDUCED BY MAXIMUM RATIO FIELD COMBINING IN FIFTH GENERATION NETWORK
Authors: Velghe Maarten , Shikhantsov Sergei , Tanghe Emmeric , Martens Luc , Joseph Wout , Thielens Arno 
Published: August 2020

Abstract
The goal of this paper is to experimentally assess the field enhancement and hotspot size of radio frequency electromagnetic fields created by the Maximum Ratio Combining (MRC) precoding scheme using lab measurements at 3.5, 5.5 and 11 GHz. MRC is an adaptive precoding scheme used by Massive Multiple Input Multiple Output systems, one of the enabling techniques of the fifth generation of telecommunications (5G). A virtual antenna array was used to compare MRC with two passive precoding schemes: the Random Phase Model (RPM) and the Centerline Beam Model (CBM). The field enhancement going from CBM to MRC was largest in obstructed line of sight (OLOS), ranging from 1.9 to 7.4 dB. The field enhancement going from RPM to MRC was about 9.5 dB across frequency bands in both line of sight (LOS) and OLOS. The hotspot size, quantified by the full width at half maximum (FWHM), ranged from 0.5 wavelengths to one wavelength.
Principles Guiding Nonpandemic Critical Care Research During a Pandemic
Authors: Cook Deborah J. , Kho Michelle E. , Duan Eric H. , Alhazzani Waleed , Takaoka Alyson , Clarke France J. , Zytaruk Nicole , Vanstone Meredith 
Published: August 2020

Objectives:
To describe the importance of critical care clinical research that is not pandemic-focused during pandemic times; outline principles to assist in the prioritization of nonpandemic research during pandemic times; and propose a guiding framework for decisions about whether, when and how to continue nonpandemic research while still honoring the moral and scientific imperative to launch research that is pandemic-focused.

Design/Data Sources:
Using in-person, email, and videoconference exchanges, we convened an interprofessional clinical research group, conducted a literature review of empirical studies, ethics documents and expert commentaries (2010 to present), and viewed traditional and social media posts (March 2020 to May 2020). Stakeholder consultation involved scientific, ethics, clinical, and administrative leaders.

Setting:
Clinical research in the ICU.

Patients:
Patients with and without coronavirus disease 2019.

Interventions:
None.

Measurements and Main Results:
While clinical research should be prioritized to advantage patients with coronavirus disease 2019 in order to care for affected patients, it ideally would not unduly disadvantage patients without coronavirus disease 2019. Thus, timely, rigorous, relevant, and ethical clinical research is needed to improve the care and optimize outcomes for both patients with and without coronavirus disease 2019, acknowledging how many studies that are not exclusively focused on coronavirus disease 2019 remain relevant to patients with coronavirus disease 2019. Considerations to continue nonpandemic-focused research include the status of the pandemic, local jurisdictional guidance, capacity and safety of bedside and research personnel, disposition of patients already enrolled in nonpandemic studies, analyzing characteristics of each nonpandemic-focused study, research oversight, and final reporting requirements.

Conclusions:
Deliberation about continuing nonpandemic research should use objective, transparent criteria considering several aspects of the research process such as bedside and research staff safety, infection control, the informed consent model, protocol complexity, data collection, and implementation integrity. Decisions to pause or pursue nonpandemic research should be proportionate, transparent, and revisited as the pandemic abates.
Clear Cell Hidradenoma—Basal Cell Carcinoma Collision
Authors: Piqué-Duran Enric , Duran-Hernández MªCristina , Pérez-Cejudo Juan A. , García-Vázquez Odalys 
Published: August 2020

Abstract:
A 91-year-old man presented with a tumor on the left temporal area, clinically suspicious of basal cell carcinoma. The histopathologic study showed a central solid-cystic tumor composed by 3 different types of cells (clear or finely granular cells, polygonal cells, and squamoid cells). It had a sclerotic stroma. At the periphery, another tumor composed by smaller interconnected nests was evident. Some nests were separated from the stroma by clefts. The stroma of this second tumor was highly cellular. There was a sharp delimitation between both tumors, with no transitional area. Immunochemistry demonstrated they are different tumor. A diagnosis of clear cell hidradenoma–basal cell carcinoma collision was performed. To the best of our knowledge, this is the first description of this challenging association.
Differential actions of indomethacin: clinical relevance in headache
Authors: Summ Oliver , Andreou Anna P. , Akerman Simon , Holland Philip R. , Hoffmann Jan , Goadsby Peter J. 
Published: August 2020

Abstract
Nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, are used routinely in the treatment of primary headache disorders. Indomethacin is unique in its use in the diagnosis and treatment of hemicrania continua and paroxysmal hemicrania. The mechanism of this specific action is not fully understood, although an interaction with nitric oxide (NO) signaling pathways has been suggested. Trigeminovascular neurons were activated by dural electrical stimulation, systemic administration of an NO donor, or local microiontophoresis of L-glutamate. Using electrophysiological techniques, we subsequently recorded the activation of trigeminovascular neurons and their responses to intravenous indomethacin, naproxen, and ibuprofen. Administration of indomethacin (5 mg·kg−1), ibuprofen (30 mg·kg−1), or naproxen (30 mg·kg−1) inhibited dural-evoked firing within the trigeminocervical complex with different temporal profiles. Similarly, both indomethacin and naproxen inhibited L-glutamate-evoked cell firing suggesting a common action. By contrast, only indomethacin was able to inhibit NO-induced firing. The differences in profile of effect of indomethacin may be fundamental to its ability to treat paroxysmal hemicrania and hemicrania continua. The data implicate NO-related signaling as a potential therapeutic approach to these disorders.
Determinants of High-Sodium Food Intake Among Indonesian Patients With Hypertension
Authors: Wicaksana Anggi Lukman , Yen Miaofen , Wang Shan-Tair , Fetzer Susan Jane 
Published: August 2020

Background
Sodium restriction is difficult for most individuals with hypertension. Intention to limit sodium intake predicts behavior. Information on the determinants of intention to restrict sodium intake is limited.

Objectives
The aims of this study were to identify (1) determinants of intention to restrict high-sodium food intake and (2) sources of sodium consumed by patients with hypertension in Indonesia.

Methods
A cross-sectional study was conducted among adult patients with hypertension (n = 206) attending cardiac clinics. A researcher-developed and tested, self-administered questionnaire that included questions about sodium restriction and a high-sodium food inventory was distributed. The quantile regression method was used to identify determinants of intention to restrict dietary sodium.

Results
The mean age of the patients with hypertension was 59 ± 10 years, and more than three-fourths were obese (n = 162, 78%). The determinants of intention to limit sodium intake included gender (β = 0.737, P = .036), attitude (β = −0.141, P = .050), and subjective norm (β = −0.283, P = .005). Men reported higher sodium consumption, while attitudes and subjective norm were negatively correlated with sodium intake. These determinants predicted 13.2% of the variance in intention to restrict dietary sodium. Subjects reported frequently consuming snacks (n = 82, 39.7%) and seasoning condiments (n = 65, 31.6%).

Conclusions
High-sodium snacks and condiments added while cooking were frequently consumed among patients with hypertension in Indonesia. Understanding the factors associated with intention to follow a low-sodium diet will assist nurses to design effective interventions that promote adherence to the low-sodium diet among those with hypertension.
Major Adverse Cardiovascular Events in Antidepressant Users Within Patients With Ischemic Heart Diseases
Authors: Kim Jae Hyun , Song Yun-Kyoung , Jang Ha Young , Shin Ju-Young , Lee Hae-Young , Ahn Yong Min , Oh Jung Mi , Kim In-Wha 
Published: August 2020

Abstract

Background
To evaluate the effect of antidepressants on the development of major adverse cardiovascular events (MACEs) in patients with ischemic heart disease (IHD), we analyzed the association between antidepressant use and the risk of MACE development.

Methods
Patients with depression and a history of IHD between 2008 and 2012 were identified by using the National Health Insurance Service database. A cohort was followed up for the development of MACE until the end of 2015. Hazard ratios (HRs) for myocardial infarction, stroke, and cardiovascular death were estimated by Cox proportional hazard regression in a propensity score–matched cohort.

Results
Over a median 4.2 years of follow-up, 2943 MACE occurred in 18,981 antidepressant users. Use of antidepressants was not associated with the incidence of MACE when compared with antidepressant nonusers (adjusted HR, 1.00; 95% confidence interval, 0.95–1.05). Among the analyses according to different classes of antidepressants, the increased risk of stroke was only observed in the subgroup of selective serotonin reuptake inhibitor (SSRI) users. Dose-response findings reported greater risk in those with higher doses of use (SSRIs with ≥1.0 defined daily dose; adjusted HR, 1.14; 95% confidence interval, 1.06–1.23), whereas duration response does not support association.

Conclusions
Compared with antidepressant nonusers, use of antidepressants was not associated with occurrence of MACEs in patients with depression and IHD. Although the overall effect of antidepressants on the risk of MACE was neutral, careful monitoring of MACE development is recommended in high-dose SSRI users.
Efficacy and safety of acupuncture for urinary retention
Authors: Zhao Qinyu , Song Bao , Chen Shenshen , Zhu Yongzheng , Jia Hongling , Liu Shenyang 
Published: August 2020

AbstractBackground:Many postoperative patients and males suffer urinary retention (UR) symptom, which directly affects their quality of life. Acupuncture is widely used by Traditional Chinese Medicine doctors to treat various postoperative urinary retention and elderly male urinary retention patients. However, acupuncture treatment of urinary retention symptoms lacks relevant multi-center clinical studies and lacks a more comprehensive meta-analysis report, which contradicts clinical practice. To confirm the safety and efficacy of acupuncture treatment of urinary retention caused by various reasons requires more comprehensive and strong evidence-based medical evidence.Methods:Databases including CNKI, PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Scopus, EBSCO were retrieved for relevant literature, with the retrieval deadline being June 23, 2020. The 2 conducted independent reading of the retrieved literature and removed the duplications, and then used the Cochrane Handbook to score the randomized controlled trials (RCTs). Only when the score is greater than 5 points can they be included. Then extract the basic information of the included literature, post-voided residual urine (PVR), maximal cystometric capacity (MCC), maximal flow rate (MFR), bladder compliance (BC), adverse events (AE), and effective rate data, and make a literature feature table. The methodological quality was evaluated with the “Risk of Bias” tool, and the meta-analysis was performed by using the RevMan 5.3.5 software. Use Stata 15 for regression analysis to find the source of heterogeneity, and try to resolve it using subgroup analysis.Results:The analysis of PVR, MCC, MFR, BC, AE and effective rate data can provide high-quality evidence for high-quality synthesis and/or descriptive analysis of the effectiveness and safety of acupuncture treatment of various causes of urinary retention.Conclusion:This study can provide more comprehensive evidence to prove whether acupuncture is effective and safe for patients with UR.Registration:The research has been registered and approved on the PROSPERO website. The registration number is CRD42019119238.
Using the bootstrapping method to verify whether hospital physicians have different h-indexes regarding individual research achievement
Authors: Kung Sheng-Chun , Chien Tsair-Wei , Yeh Yu-Tsen , Lin Jui-Chung John , Chou Willy 
Published: August 2020

Abstract

Background:
Individual researchers’ achievements (IRA) are determined by both personal publications and article citations such as Author Impact Factor, h-index, and x-index. Due to those indicators not truly supporting a normal distribution, the traditional t-test and Analysis of variance are not allowed for RA comparison in groups. The objective of this study is to use the bootstrapping method to verify whether hospital physicians have different h-indexes.

Methods:
We downloaded 63,266 journal articles with their corresponding citations for 2128 researchers from a Taiwan university website on December 10, 2019. Their IRAs were assessed using the bibliometric h-index. A pyramid plot was used to compare the h-index patterns between institutes. The x-index and the Kano model were found to be complemental to the h-index for identifying the group IRA characteristics and rankings, including colleges and departments in the university study, the School of Medicine, and the Affiliated Hospital. The bootstrapping method was applied with an estimated 95% confidence interval (CI) to distinguish the differences in physicians between the Internal Medicine and Surgery departments. The stronger-than-the-next coefficient (SC) for the highest represents the RA strength.

Results:
The highest h-indices were found in the College of Engineering, School of Medicine, and the Department of Internal Medicine in groups of colleges (SC = 0.71), all departments (SC = 0.83), the School of Medicine (SC = 0.74), and the Affiliated Hospital (SC = 0.56), respectively. No difference in h-index for hospital physicians was found between departments in Internal Medicine (Mean = 2.14, 95% CI = 1.02,3.26) and Surgery (mean = 2.5, 95%CI = 1.48, 3.52).

Conclusions:
The x-index and the Kano models can complement the h-index for identifying group IRA characteristics. The bootstrapping method allows estimation of the sampling distribution for almost any statistic using random sampling methods and gains measures of accuracy (as defined by 95% CI). The finding of no difference in h-index for hospital physicians between departments in Internal Medicine and Surgery requires further investigation in the future.
A randomized controlled trial for gualou danshen granules in the treatment of unstable angina pectoris patients with phlegm-blood stasis syndrome
Authors: Guo Jianbo , Dai Shuang , Ding Yukun , He Haoqiang , Zhang Hui , Dan Wenchao , Qin Kun , Wang Hui , Li Anqi , Meng Peipei , Li Shangjin , He Qingyong 
Published: August 2020

Abstract

Introduction:
Unstable angina pectoris is an acute exacerbation secondary to coronary artery occlusion. In routine clinical treatment, patients with unstable angina pectoris are prone to recurrence or aggravation of symptoms. Based on the traditional Chinese medicine (TCM) theory, phlegm, and blood stasis are one of the main pathological factors of unstable angina pectoris. The treatment of unstable angina pectoris with phlegm-blood stasis syndrome by Gualou Danshen granules (GLDS) has been the focus of many clinical trials. However, there is no evidence to prove the safety or clinical efficacy of GLDS.

Methods and analysis:
In this study, we will conduct a 4-week randomized, controlled feasibility study, with participants recruited from Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine. Sixty subjects are to be diagnosed as having phlegm-blood stasis syndrome and randomly divided into a treatment group (GLDS) and placebo group in a 1:1 ratio. Result measurements will include therapeutic indicators (Clinical Symptom Rating Scale, Phlegm-Blood Stasis Syndrome Scale, and Seattle Angina Questionnaire) and safety indicators (blood routine, urine routine, electrocardiogram, liver function, and kidney function). The clinical data management system (http://www.tcmcec.net/) will be used to collect and manage data. Quality control will be implemented according to good clinical practice.

Discussion:
Previous TCM clinical trials have investigated if adding GLDS to standard routine treatment can improve the therapeutic effect in patients with unstable angina pectoris. This study focuses on the safety and efficacy of GLDS on unstable angina pectoris of phlegm-blood stasis type, in order to obtain relevant clinical evidence.

Trial registration:
This study is approved by the Ethics Committee of Guang’anmen Hospital of the China Academy of Chinese Medical Sciences (no. 2019–187-KY-02) and is registered with chictr.org (registration number ChiCTR2000031780).
Association between hyperuricemia, gout, urate lowering therapy, and osteoarthritis
Authors: Zhu Junyu , Wang Yilun , Chen Yuhao , Li Xiaoxiao , Yang Zidan , Li Hui 
Published: August 2020

Abstract

Introduction:
Osteoarthritis (OA), a chronic and degenerative joint disease characterized by articular cartilage degeneration, sclerosis of subchondral bone, and osteophyte formation, is deemed a leading cause of activity limitation and disability among the elderly people. Serum uric acid (UA) is a terminal metabolite of purine compound, while hyperuricemia (HU) and UA crystals are recognized causes of gout. Several studies have investigated the correlations between HU, gout and OA, but the findings are inconclusive. We are also concerned whether the urate lowering therapy (ULT) can become a potential treatment for OA and intend to undertake this meta-analysis to clarify the related hypotheses.

Methods:
Systematic literature search will be conducted on PubMed, Embase, and Web of Science to identify relevant studies up to February 2020 using appropriate search strategies. All citations and abstracts retrieved from literature search will be assessed by two reviewers independently. The Newcastle-Ottawa Scale or the Cochrane risk of bias assessment tool will be used as appropriate to assess the quality and the risk of bias of the included studies. The heterogeneity and the publication bias of the studies will be investigated accordingly.

Results:
We propose to undertake this meta-analysis as a feasible approach to clarify the associations between HU, gout or ULT, and OA.

Discussions:
This meta-analysis will help to strengthen our knowledge of the pathogenesis of OA and promote the development of preventive or treatment strategies.

Registration:
PROSPERO registration number CRD42020168769.
Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability
Authors: Bogliş Alina , Cosma Adriana S. , Tripon Florin , Bãnescu Claudia 
Published: August 2020

Abstract

Introduction:
The oligophrenin-1 (OPHN1) gene, localized on the X chromosome, is a Rho-GTPase activating protein that is related to syndromic X-linked intellectual disability (XLID). XLID, characterized by brain anomalies, namely cerebellar hypoplasia, specific facial features, and intellectual disability, is produced by different mutations in the OPHN1 gene.

Patient concerns:
In this report, we present the clinical and molecular findings of a family affected by a mild XLID due to a deletion in the OPHN1 gene, exon 21, Xq12 region using Multiplex Ligation-dependent Probe Amplification (MLPA) analysis. The clinical features present in the family are a mild developmental delay, behavioral disturbances, facial dysmorphism, pes planus, nystagmus, strabismus, epilepsy, and occipital arachnoid cyst.

Interventions:
The MLPA analysis was performed for investigation of the copy number variations within the X chromosome for the family.

Diagnosis and outcome:
The MLPA analysis detected a deletion in the OPHN1 gene, exon 21 for the proband, and a heterozygous deletion for the probands mother. The deletion of the Xq12 region of maternal origin, including the exon 21 of the OPHN1 gene, confirmed for the probands nephew.

Lessons:
Our findings emphasize the utility of the MLPA analysis to identify deletions in the OPHN1 gene responsible for syndromic XLID. Therefore, we suggest that MLPA analysis should be performed as an alternative diagnostic test for all patients with a mild intellectual disability associated or not with behavioral disturbances, facial dysmorphism, and brain anomalies.
Pseudodiphallia: a rare kind of diphallia
Authors: Zhang Wenchao , Yu Nanze , Liu Zhifei , Wang Xiaojun 
Published: August 2020

Abstract

Rationale:
Pseudodiphallia, as a rare kind of diphallia, which is characterized by a small accessory penile-like tissue without a normal penile anatomy structure. Only a few cases have been reported. Here, we report a case of pseudodiphallia with phimosis and bilateral extrarenal pelvis.

Patient concerns:
A 23-year-old male visited our hospital with a complaint of external genitalia malformation. Physical examination revealed a normal-sized penis with phimosis, and an extra half glans horizontally attached to the right side of the normal glans penis is visible after completely retracting the foreskin. The CT urography showed a bilateral extrarenal pelvis, and no other abnormalities were found in the kidneys, ureter, bladder, and vertebral bodies.

Diagnosis:
Based on the physical examination and the CT urography results, the 23-year-old male was diagnosed with Pseudodiphallia.

Intervention:
Excessive penile tissue was resected, and a foreskin circumcision operation was performed under general anesthesia.

Outcomes:
The patient recovered smoothly without complications (no infection, hematoma, or wound dehiscence) after surgery. At 6 months follow-up, the patient was content with the external genitalia's appearance, and the urination and erectile function were normal.

Lessons:
Pseudodiphallia is a rare kind of diphallia, and this is the first report on pseudodiphallia with a bilateral extrarenal pelvis. CT urography can be used to assess the associated internal anomalies before surgery.