bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of adsorbents from agricultural wastes as alternative fillers in mixed matrix membrane for gas separation: A review
Authors: Ghazali Alia Aqilah , Rahman Sunarti Abd , Samah Rozaimi Abu 
Published: May 2020

AbstractMixed matrix membrane (MMM), formed by dispersing fillers in polymer matrix, has attracted researchers’ attention due to its outstanding performance compared to polymeric membrane. However, its widespread use is limited due to high cost of the commercial filler which leads to the studies on alternative low-cost fillers. Recent works have focused on utilizing agricultural wastes as potential fillers in fabricating MMM. A membrane with good permeability and selectivity was able to be prepared at low cost. The objective of this review article is to compile all the available information on the potential agricultural wastes as fillers in fabricating MMM for gas separation application. The gas permeation mechanisms through polymeric and MMM as well as the chemical and physical properties of the agricultural waste fillers were also reviewed. Additionally, the economic study and future direction of MMM development especially in gas separation field were discussed.
Self-Regulation Mindsets: Relationship to Coping, Executive Functioning, and ADHD
Authors: Burnette Jeni L. , Babij Alexandra D. , Oddo Lauren E. , Knouse Laura E. 
Published: May 2020

Introduction: We examined if mindsets about the stability (fixed mindset) or malleability (growth mindset) of self-regulation predicted coping with setbacks. We also investigated relations with Executive Function (EF) deficits and ADHD status.Methods: In two correlational studies (Study 1, N = 204; Study 2, N = 184, ADHD, n = 34, Non-ADHD, n = 150), participants reported on their mindsets, self-regulatory abilities, and responded to assessments related to a setback about which they wrote.Results: Across both studies, growth mindsets predicted less negative affect, greater efficacy, and less avoidant coping. The relationship between mindsets and these responses did not depend on EF deficits (Study 1 and Study 2) nor ADHD diagnostic status (Study 2), but participants with greater EF deficits and an ADHD diagnosis reported weaker growth mindsets of self-regulation.Discussion: Findings support the evaluation and development of growth mindset interventions to help individuals with disorders of self-regulation to cope more effectively.
Reactions to Witnessing Ethnic Microaggressions: An Experimental Study
Authors: Torres Lucas , Reveles Alexandra K. , Mata-Greve Felicia , Schwartz Sarah , Domenech Rodriguez Melanie M. 
Published: May 2020

Introduction: Minimal research has examined how witnesses identify and respond to ethnic microaggressions including the role of colorblind racial attitudes. Method: University student participants (N = 401) were randomly assigned to one of three experimental conditions in which they witnessed a research decoy experiencing an ethnic microaggression, an overt discriminatory interaction, or a neutral interaction (control). Results: The study findings showed that 46% of participants who witnessed an ethnic microaggression identified it as unfair or differential treatment compared to 84% of those who observed an overt form of discrimination. Multilevel model analyses revealed a 3-way interaction (time × experimental condition × colorblind racial attitudes) such that participants with low colorblind racial attitudes had significant increases in negative affect and systolic blood pressure after witnessing overt discrimination. Discussion: Key differences exist in the identification and responses associated with witnessing an ethnic microaggression compared to overt discrimination. Findings suggest that shifting colorblind racial attitudes may be a promising area of intervention to improve detection of ethnic microaggressions.
A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons
Authors: Calvo Paula M. , de la Cruz Rosa R. , Pastor Angel M. 
Published: May 2020

AbstractVascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic effects on lesioned neurons. Hitherto, the administration of VEGF in different animal models of lesion or disease has been conducted following a chronic protocol of administration. We questioned whether a single dose of VEGF, administered intraventricularly, could induce long-term neurotrophic effects on injured motoneurons. For this purpose, we performed in cats the axotomy of abducens motoneurons and the injection of VEGF into the fourth ventricle in the same surgical session and investigated the discharge characteristics of axotomized and treated motoneurons by single-unit extracellular recordings in the chronic alert preparation. We found that injured motoneurons treated with a single VEGF application discharged with normal characteristics, showing neuronal eye position (EP) and velocity sensitivities similar to control, thereby preventing the axotomy-induced alterations. These effects were present for a prolonged period of time (50 d) after VEGF administration. By confocal immunofluorescence we also showed that the synaptic stripping that ensues lesion was not present, rather motoneurons showed a normal synaptic coverage. Moreover, we demonstrated that VEGF did not lead to any angiogenic response pointing to a direct action of the factor on neurons. In summary, a single dose of VEFG administered just after motoneuron axotomy is able to prevent for a long time the axotomy-induced firing and synaptic alterations without any associated vascular sprouting. We consider that these data are of great relevance due to the potentiality of VEGF as a therapeutic agent in neuronal lesions and diseases.
Pupil Diameter Tracks Statistical Structure in the Environment to Increase Visual Sensitivity
Authors: Schwiedrzik Caspar M. , Sudmann Sandrin S. 
Published: May 2020

Pupil diameter determines how much light hits the retina and, thus, how much information is available for visual processing. This is regulated by a brainstem reflex pathway. Here, we investigate whether this pathway is under the control of internal models about the environment. This would allow adjusting pupil dynamics to environmental statistics to augment information transmission. We present image sequences containing internal temporal structure to humans of either sex and male macaque monkeys. We then measure whether the pupil tracks this temporal structure not only at the rate of luminance variations, but also at the rate of statistics not available from luminance information alone. We find entrainment to environmental statistics in both species. This entrainment directly affects visual processing by increasing sensitivity at the environmentally relevant temporal frequency. Thus, pupil dynamics are matched to the temporal structure of the environment to optimize perception, in line with an active sensing account.SIGNIFICANCE STATEMENTWhen light hits the retina, the pupil reflexively constricts. This determines how much light and thus how much information is available for visual processing. We show that the rate at which the pupil constricts and dilates is matched to the temporal structure of our visual environment, although this information is not directly contained in the light variations that usually trigger reflexive pupil constrictions. Adjusting pupil diameter in accordance with environmental regularities optimizes information transmission at ecologically relevant temporal frequencies. We show that this is the case in humans and macaque monkeys, suggesting that the reflex pathways that regulate pupil diameter are under some degree of cognitive control across primate species.
Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study
Authors: Benson Curtis A. , Fenrich Keith K. , Olson Kai-Lan , Patwa Siraj , Bangalore Lakshmi , Waxman Stephen G. , Tan Andrew M. 
Published: May 2020

Neuropathic pain is an intractable medical condition with few or no options for effective treatment. Emerging evidence shows a strong structure-function relationship between dendritic spine dysgenesis and the presence of neuropathic pain. Postmortem tissue analyses can only imply dynamic structural changes associated with injury-induced pain. Here, we profiled thein vivodynamics of dendritic spines over time on the same superficial dorsal horn (lamina II) neurons before and after peripheral nerve injury-induced pain. We used a two-photon, whole-animal imaging paradigm that permitted repeat imaging of the same dendritic branches of these neurons in C57/Bl6 Thy1-YFP male mice. Our study demonstrates, for the first time, the ongoing, steady-state changes in dendritic spine dynamics in the dorsal horn associated with peripheral nerve injury and pain. Ultimately, the relationship between altered dendritic spine dynamics and neuropathic pain may serve as a structure-based opportunity to investigate mechanisms of pain following injury and disease.SIGNIFICANCE STATEMENTThis work is important because it demonstrates for the first time: (1) the powerful utility of intravital study of dendritic spine dynamics in the superficial dorsal horn; (2) that nerve injury-induced pain triggers changes in dendritic spine steady-state behavior in the spinal cord dorsal horn; and (3) this work opens the door to further investigationsin vivoof spinal cord dendritic spine dynamics in the context of injury and disease.
Evaluation of progression to diabetes in high-risk patients eligible to attend the ‘Walking Away from Diabetes’ educational intervention: a retrospective cohort study
Authors: Jonker Leon , Fisher Stacey Jayne , Westgate Robert , Overend Louise 
Published: May 2020

Aims: To retrospectively assess the efficacy of a pragmatic education programme called ‘Walking Away from Diabetes’ (WAD), a single-session intervention aimed at patients who are at risk of developing type 2 diabetes mellitus (T2DM).Methods: Baseline and follow-up data for 6,116 patients, identified as ‘at risk of diabetes’ in the period April 2012 to March 2016, were assessed for T2DM status in January 2018. Any differences in outcome between WAD attenders and non-attenders was explored using Kaplan–Meier, log rank testing and Cox regression analyses.Results: During the follow-up period, 426 of 3,470 (12.3%) WAD attenders and 349 of 2,646 (13.2%) non-attenders were diagnosed with T2DM (p=0.068, log rank test). Cox regression showed that HbA1c (hazard ratio (HR) 1.23, p<0.001) and high density lipid levels (HR 0.67, p<0.001) rather than WAD attendance (HR 0.89, p=0.11) were the two main factors associated with progress from ‘at risk’ to T2DM.Conclusions: Although the wider health impact of the WAD programme was not considered here, session attendance does not appear to reduce the risk of developing T2DM. However, other factors influence the risk of developing T2DM. It is essential for educational programmes, designed to have a preventative effect for people at risk of diabetes, to be assessed for short- and long-term efficacy.
A novel TRPM6 variant (c.3179T>A) causing familial hypomagnesemia with secondary hypocalcemia
Authors: Lomelino-Pinheiro Sara , Margarida Bastos , Lages Adriana de Sousa 
Published: May 2020

Summary
Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder (OMIM# 602014) characterized by profound hypomagnesemia associated with hypocalcemia. It is caused by mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6). It usually presents with neurological symptoms in the first months of life. We report a case of a neonate presenting with recurrent seizures and severe hypomagnesemia. The genetic testing revealed a novel variant in the TRPM6 gene. The patient has been treated with high-dose magnesium supplementation, remaining asymptomatic and without neurological sequelae until adulthood. Early diagnosis and treatment are important to prevent irreversible neurological damage.

Learning points:

Loss-of-function mutations of TRPM6 are associated with FHSH.

FHSH should be considered in any child with refractory hypocalcemic seizures, especially in cases with serum magnesium levels as low as 0.2 mM.

Normocalcemia and relief of clinical symptoms can be assured by administration of high doses of magnesium.

Untreated, the disorder may be fatal or may result in irreversible neurological damage.
Peran Kepemimpinan Kepala Sekolah Dalam Mengembangkan Kompetensi Pedagogik Guru
Authors: Suroya A.Eri Iman 
Published: May 2020

Keberhasilan SMK Bandung Timur dan SMK Bakti Nusantara 666 dalam usaha mencapai SMK unggulan ditunjang oleh visi-misi kepemimpinan kepala sekolah dalam mengelola dan mewujudkan pendidikan yang berkualitas. Kegiatan pembinaan guru dalam bentuk In-House Training dan workshop merupakan program aktualisasi pengembangan kompetensi pedagogik guru di SMK Bandung Timur dan SMK Bakti Nusantara 666, hal tersebut disebabkan lemahnya produktifitas dan efektifitas tenaga pendidik terhadap proses pebelajaran. Metode Penelitian menggunakan pendekatan kualitatif, teknik pengumpulan datanya dilakukan dengan, wawancara mendalam, observasi berperan serta, dan studi dokumentasi. Hasil penelitian secara keseluruhan menunjukkan bahwa; Peran kepemimpinan Kepala Sekolah dalam mengembangkan kompetensi pedagogik guru di SMK Bandung Timur dan SMK Bakti Nusantara 666 secara teknis maupun proses pelaksanaannya memiliki ragam cara masing-masing, Perencanaan pengembangan kompetensi pedagogik guru mencakup; a) Formulasi rumusan dan tujuan pengembangan, b) strategi/langkahlangkah pengembangan, c) formulasi program pengembangan, d) penentuan waktu dan tempat, e) rencana anggaran, Pelaksanaan pengembangan kompetensi pedagogik adalah kegiatan In-House Training, dan Workshop pengembangan kurikulum KTSP, dilaksanakan oleh sekolah, Evaluasi pengembangan dilakukan dengan; Supervisi (kunjungan kelas), Kegiatan rapat sekolah, Monitoring guru (CCTV). 5) faktor penunjang mencakup Perubahan Kurikulum,Persaingan dunia pendidikan, Kebutuhan masyarakat, Alokasi dana subsidi, dan Kegiatan akreditasi sekolah. Faktor penghambat mencakup anggaran dana terbatas, fasilitas yang kurang, dan keterbatasan waktu
Implementasi Metode Talaqqi Dalam Pembelajaran Tahsin Dan Tahfiz Al-Qur’an
Authors: Rizalludin Azis 
Published: May 2020

Penelitian ini dilatarbelakangi adanya tingkat keterampilan siswa dalam membaca al-Qur’an di SDIT Khaira Ummah Tanjungsari yang belum memenuhi indikator pencapaian yang telah ditetapkan. Hal ini didasari atas pengamatan di lapangan yang peneliti lakukan di kelas III SDIT Khaira Ummah Tanjungsari tahun pelajaran 2016/2017. Terdapat sebanyak 10 siswa (40%) pada kategori tidak lancar membaca al-Qur’an (terbata-bata) dan 8 siswa (32%) berada pada kategori kurang lancar dalam membaca al-Qur’an dari total 25 siswa di kelas 3 SDIT Khaira Ummah Tanjungsari. Penelitian ini bertujuan untuk mendeskripsikan implementasi metode talaqqi dalam pembelajaran tahsin dan tahfiz al-Qur’an (Penelitian di Kelas III SDIT Khaira Ummah Tanjungsari). Yaitu menggambarkan desain pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi, menggambarkan pelaksanaan dan evaluasi pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi di kelas 3 SDIT Khaira Ummah Tanjungsari. penelitian menggunakan pendekatan kualitatif deskriptif dan metode yang digunakan adalah metode deskriptif analisis, sedangkan metode pengumpulan data yang digunakan meliputi observasi, interview atau wawancara, dokumentasi dan studi pustaka. Hasil penelitian ini menunjukan bahwa Desain pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi di SDIT Khaira Ummah Tanjungsari mencakup desain pengaturan guru, pengaturan siswa, pengaturan waktu dan tempat belajar serta desain materi ajar tahsin dan tahfiz al-Qur’an, Pelaksanaan pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi.
Pola Komunikasi Penyuluh Agama Islam Di Daerah 3T
Authors: Andrian Bob 
Published: May 2020

Daerah Tertinggal, Terluar dan Terdepan (3T) adalah wilayah strategis negara yang mesti diperhatikan. Mengingat banyak sekali isu dan problematika yang terjadi di Daerah 3T, mulai dari krisis moral, akhlak, sampai pada krisis nasionalisme. Faktor utama penyebab problematika tersebut adalah dikarenakan oleh faktor geografis, sosiol dan budaya yang berkembang di Daerah 3T. Kondisi tersebut tentu berdampak pada aspek pengembangan masyarakat, termasuk diantaranya kegiatan penyuluhan sosial keagamaan. Bertujuan untuk mengkaji secara mendalam dan mendeksripsikan Pola Komunikasi Penyuluh Agama Islam di Daerah 3T Kecamatan Sajingan Besar Kabupaten Sambas sesuai dengan tugas dan fungsi pokok, yaitu fungsi Informatif, Edukatif, Konsultatif dan Advokatif. Adapun untuk menjawab kedua konsep tersebut teori yang digunakan adalah teori arah informasi dan teori atribusi (subjektivitas) dalam proses penyuluhan kepada masyarakat di Daerah 3T Kecamatan Sajingan Besar. Paradigma penelitian yang digunakan adalah naturalistik dengan pendekatan fenomenologi, jenis penelitian kualitatif dengan metode studi kasus. Hasil penelitian berdasarkan tujuan dan fokus masalah dapat disimpulkan bahwa Pola Komunikasi Penyuluh Agama Islam dalam melaksanakan fungsi pokok penyuluhan kepada masyarakat di Daerah 3T Kecamatan Sajingan Besar baik itu fungsi informatif, edukatif, konsultatif dan advokatif.
Komunikasi Spiritual Syekh Muhammad Abdul Gaos Saefulloh Maslul Al-Qodiri An-Naqsyabandi Al-Kamil
Authors: Usman Maman 
Published: May 2020

Abah Aos adalah seorang da’i dan mursyid ke 38 pada Tarekat Qodiriyyah Naqsyabandiyyah Suryalaya (TQNS) bertempat di Pesantren Sirnarasa yang terletak di Dusun Cisirri, Desa Ciomas Kecamatan Panjalu Kabupaten Ciamis - Jawa Barat. Abah Aos dikenal sebagai da’i yang memiliki akhlaq yang dicontohkan oleh Rosululloh SAW. baik di lingkungan keluarga, masyarakat, pemerintah. Wilayah aktivitas dakwah Tarekat yang menjadi jalan hidupnya, Abah Aos memperlihatkan kecemerlangan dakwahnya sehingga TQNS diterima oleh semua kalangan lintas madzhab sampai belahan Amerika..Penelitian ini berpijak pada teori tindakan yang dikemukakan oleh Max Weber. Dengan Metode yang penulis gunakan dalam penelitian ini adalah metode kualitatif, metode penelitian yang digunakan di lapangan mengenai hal-hal yang sedang terjadi dengan inti dari penelitian ini adalah menganalisa tentang Komunikasi Spiritual Abah Aos dalam gerakan dakwah Tarekat Qodiriyah Naqsabandiyah Suryalaya dengan jenis metode yang digunakan metode kualitatif dengan pendekatan studi fenomenologi. Berdasarkan hasil penelitian dapat diketahui bahwa gerakan dakwah TQNS Abah Aos: secara Konsep, bahwa inti ajaran TQNS terbagi dalam enam bahasan, yaitu: Semua manusia Muslim adalah calon wali Alloh, ilmu amaliyah, amal ilmiyah, Talqin, Dzikrulloh, Syari’at Tarekat, hakikat dan Ma’rifat. Sikap dakwah TQNS Abah Aos diantaranya ada perkembangan dalam dakwah TQNS antara Abah Sepuh, Abah Anom, dan Abah Aos. Dalam hal talqin Dzikir Abah Aos, memberikannya kepada siapa saja yang sudah berusia 17 tahun tanpa harus meminta talqin. Tradisi, dalam riyadoh dipermudah, hanya diharuskan melaksanakan amaliyah yang tertera dalam buku Amaliyah Mursyid dan amalan-amalan tertentu
Modal manusia dalam prespektif Islam hubungannya dengan Kinerja Perusahaan
Authors: Nurrohman Nurrohman 
Published: May 2020

Dalam tulisan ini membahas Penekanan prinsip dan nilai ajaran islam pada variabel-variabel yang sudah populer dalam pandangan atau kajian konvensional. Tampaknya sudah terabaikan dan terlupakan oleh manajer-pemilik muslim padahal itu semua merupakan unsur penting serta sangat berharga dari sumber daya manusia Islam yang memang jarang di adopsi oleh mereka dalam operasi bisnis yang dijalankannya. Variabel-variabel itu adalah motivasi, pengetahuan, pengalaman dan pelatihan bisnis. Penulisan artikel ini menggunakan metode survei literatur. Penggunaan metode ini dengan memanfaatkan sumber daya perpustakaan dalam memperoleh data, melacak sumber-sumber sebelumnya untuk menyiapkan kerangka kerja teoritis dan mempertajam metodologi. Prinsip-prinsip yang dipegang seorang modal manusia islam selain untuk meningkatkan produktifitas dalam mencapai laba perusahaan yang maksimal juga mendapatkan ridho Allah swt melalui pekerjaan yang sedang dikerjakannya.
Molecular Guided Treatments in Gynecologic Oncology: Analysis of a Real-World Precision Cancer Medicine Platform
Authors: Taghizadeh Hossein , Mader Robert M. , Müllauer Leonhard , Aust Stefanie , Polterauer Stephan , Kölbl Heinz , Seebacher Veronika , Grimm Christoph , Reinthaller Alexander , Prager Gerald W. 
Published: May 2020

Abstract

Introduction
Advanced gynecologic cancers have a poor prognosis and constitute a major challenge for adequate treatment strategies. By analyzing and targeting molecular alterations, molecular guided treatments may be a viable option for the treatment of advanced gynecologic cancers.

Patients and Methods
In this single-center, real-world retrospective analysis of our platform for precision cancer medicine (PCM), we describe the molecular profiling of 72 patients diagnosed with different types of advanced gynecologic malignancies. Tumor samples of the patients were examined by next-generation sequencing panel and immunohistochemistry (IHC).

Results
In total, we identified 209 genetic aberrations in 72 patients. The ten most frequent alterations were TP53 (n = 42, 20%), KRAS (n = 14, 6.6%), PIK3CA (n = 11, 5.2%), PIK3R1 (n = 9, 4.3%), ATR (n = 8, 3.8%), PTEN (n = 8, 3.8%), BRCA1 (n = 6, 2.8%), NF1 (n = 4, 1.9%), NOTCH1 (n = 4, 1.9%), and POLE (n = 4, 1.9%), which account for more than half of all molecular alterations (52.6%). In 21 (29.1%) patients only one mutation could be detected, and 44 (61.1%) patients had more than one mutation. No molecular alterations were detected in seven (9.7%) patients. IHC detected expression of phosphorylated mammalian target of rapamycin and epidermal growth factor receptor in 58 (80.6%) and 53 (73.6%) patients, respectively. In over two thirds (n = 49, 68.1%), a targeted therapy was suggested, based on the identified genetic aberrations. The most frequently recommended specific treatment was the combination of everolimus with exemestane (n = 18, 25 %).

Conclusion
Based on our observations, it seems that PCM might be a feasible approach for advanced gynecologic cancers with limited treatment options.

Implications for Practice
Nowadays molecular profiling of advanced gynecologic malignancies is feasible in the clinical routine. A molecular portrait should be done for every patient with an advanced therapy-refractory gynecologic malignancy to offer molecular-based treatment concepts.
Dual Fulvestrant-Trametinib Therapy in Recurrent Low-Grade Serous Ovarian Cancer
Authors: Bussies Parker L. , Schlumbrecht Matthew 
Published: May 2020

Abstract
Low-grade serous ovarian carcinoma (LGSOC) is known to exhibit chemoresistance. Effective treatment options for recurrent disease are few and often limited to hormone antagonism. Combination of endocrine therapies with MEK-inhibitors displays synergism in preclinical ovarian cancer models, however. This brief communication presents the use of combination anti-estrogenic and MEK-inhibitor therapies, fulvestrant and trametinib, as treatment in a heavily pretreated patient with estrogen receptor-positive, recurrent LGSOC. The dual-therapy regimen was well tolerated and appeared to confer 9 months of progression-free survival. Further investigation is warranted to explore this effect.