bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and treatment of infantile malignant solid tumors in beijing, China: A multicenter 10‐year retrospective study
Authors: Jin Mei , Tian Zhi , Xie Yao , Zhang Zhaoxia , Li Miao , Yu Yaxiong , Zhang Weiling , Zhao Junyang , Wang Huanmin , Zeng Qi , Li Long , Ge Ming , Sun Ning , Zhang Xiaolun , Gong Jian , Wu Wanshui , Liu Rong , Zhao Weihong , Huang Dongsheng , Ma Xiaoli 
Published: September 2020

AbstractImportanceCancer is the main cause of death by disease in children. Children experience the highest incidence of cancer in the first year of life. However, there is no comprehensive registration system for children with tumors in China.ObjectiveTo summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing, China, thereby providing evidence to guide further clinical research.MethodsFrom January 1, 2010 to December 31, 2019, patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing. The epidemiology, clinical features, and therapeutic effects of tumors in these patients were analyzed retrospectively. All patients were followed up until March 31, 2020.ResultsIn total, 938 patients were enrolled in this study. There were 530 boys (56.5%) and 408 girls (43.5%); the median age was 6.0 months (range, 0–12.0 months). The three most common tumors were retinoblastoma in 366 patients (39.0%), neuroblastoma in 266 patients (28.4%), hepatoblastoma in 133 patients (14.2%), and central nervous system tumors in 52 patients (5.5%). The estimated 5‐year overall survival rate was 81.3% ± 1.8%, and the 5‐year event‐free survival rate was 71.8% ± 2.9%. The 5‐year overall survival rates of non‐rhabdomyosarcoma soft tissue sarcoma, neuroblastoma, and retinoblastoma were 100%, 88% ± 2.2%, and 86.9% ±2.1%, respectively. The 5‐year event‐free survival rates were 81.1% ± 2.7% for neuroblastoma, 81.6% ± 9.8% for non‐rhabdomyosarcoma soft tissue sarcoma, and 72.7% ± 14.1% for extracranial malignant germ cell tumors.InterpretationThe three most common infantile malignant solid tumors were retinoblastoma, neuroblastoma, and hepatoblastoma. Multidisciplinary combined diagnosis and treatment is needed for infantile tumors.
Upfront consolidation treatment with 131I‐mIbG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high‐risk neuroblastoma
Authors: Feng Jianhua , Cheng Frankie WT , Leung Alex WK , Lee Vincent , Yeung Eva WM , Ching Lam Hoi , Cheung Jeanny , Lam Grace KS , Chow Terry TW , Yan Carol LS , Kong Li Chi 
Published: September 2020

AbstractImportance131I‐metaiodobenzylguanidine (131I‐mIBG) has a significant targeted antitumor effect for neuroblastoma. However, currently there is a paucity of data for the use of 131I‐mIBG as a “front‐line” therapeutic agent in those patients with newly diagnosed high‐risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy (MAC).ObjectiveTo evaluate the feasibility of upfront consolidation treatment with 131I‐mIBG plus MAC and hematopoietic stem cell transplantation (HSCT) in high‐risk neuroblastoma patients.MethodsA retrospective, single‐center study was conducted from 2003–2019 on newly diagnosed high‐risk neuroblastoma patients without progressive disease (PD) after the completion of induction therapy. They received 131I‐mIBG infusion and MAC followed by HSCT.ResultsA total of 24 high‐risk neuroblastoma patients were enrolled with a median age of 3.0 years at diagnosis. After receiving this sequential consolidation treatment, 3 of 13 patients who were in partial response (PR) before 131I‐mIBG treatment achieved either complete response (CR) (n = 1) or very good partial response (VGPR) (n = 2) after HSCT. With a median follow‐up duration of 13.0 months after 131I‐mIBG therapy, the 5‐year event‐free survival and overall survival rates estimated were 29% and 38% for the entire cohort, and 53% and 67% for the patients who were in CR/VGPR at the time of 131I‐mIBG treatment.InterpretationUpfront consolidation treatment with 131I‐mIBG plus MAC and HSCT is feasible and tolerable in high‐risk neuroblastoma patients, however the survival benefit of this 131I‐mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I‐mIBG treatment.
Acute myeloid leukemia following a primary mediastinal germ cell tumor
Authors: Hong Huimin , Su Yan , Chen Chenghao , He Lejian , Zhu Shuai , Lin Wei , Jin Mei , Wang Xisi , Zhang Ruidong , Zheng Huyong , Zeng Qi , Ma Xiaoli 
Published: September 2020

AbstractIntroductionThere is a known association between primary mediastinal germ cell tumor (PMGCT) and hematologic malignancy that is not linked to treatment. They are exceptionally rare entities with a low morbidity and a poor prognosis.Case presentationAn 11‐year‐old boy presented with an anterior mediastinal mass diagnosed as a malignant germ cell tumor on the basis of an excisional biopsy. He was found to have acute myeloid leukemia (AML) two years after the chemotherapy for his germ cell tumor. The clinical course was very aggressive with a survival time of only 1 week after diagnosis of AML associated with PMGCT.ConclusionAML associated with PMGCT needs to be diagnosed correctly. Relevant examinations should be carried out in patients with PMGCTs during and after chemotherapy, and long‐term follow‐up is still necessary to reduce the risk of morbidity and mortality.
Clinical characteristics and prognosis of pulmonary inflammatory myofibroblastic tumor: An over 10‐year retrospective analysis
Authors: Zhang Na , Zeng Qi , Chen Chenghao , Yu Jie , Yan Dong , Xu Changqi , Liu Dingyi , Zhang Qian , Zhang Xu 
Published: September 2020

AbstractImportancePulmonary inflammatory myofibroblastic tumors (PIMTs) are primary lung tumors in children. Misdiagnosis easily occurs because of the nonspecific clinical manifestations, laboratory examination results, and imaging findings in affected patients.ObjectiveTo summarize the clinical characteristics, diagnosis, and prognosis of children with PIMTs.MethodsThis retrospective analysis included 23 children with PIMTs who received treatment in our hospital from January 2008 to January 2019. The clinical manifestations, laboratory examination results, and computed tomography findings were retrospectively analyzed.ResultsThe population included 13 boys and 10 girls, with a median age at onset of 78 months (range, 10–126 months). Fourteen patients had PIMT lesions in the right lung and nine patients had PIMT lesions in the left lung. The surgical procedures included pulmonary wedge resection, pulmonary lobectomy, and total pneumonectomy. The median operation time was 115 min (range, 45–235 min); the median intraoperative blood loss volume was 30 mL (range, 3–500 mL). During the operation, one patient each had pulmonary hemorrhage, vena cava hemorrhage, and thoracic duct injury. Postoperative complications included pulmonary embolism in one patient and tumor recurrence in two patients; neither of these complications recurred after reoperation. The median follow‐up period was 49 months (range, 2–127 months).InterpretationChildren with PIMTs exhibited good prognoses and primarily underwent surgical resection as treatment. Complete preoperative evaluation should be performed in affected patients.
Non‐invasive home ventilation using the average volume assured pressure support feature in an infant with severe bronchopulmonary dysplasia and chronic respiratory failure
Authors: Saddi Vishal , Thambipillay Ganesh , Teng Arthur 
Published: September 2020

AbstractIntroductionWhile majority of infants with bronchopulmonary dysplasia (BPD) can be discharged home without low flow oxygen or on supplemental low flow oxygen, some require long term home mechanical ventilation.Case presentationWe present a case of an extremely premature infant with severe bronchopulmonary dysplasia who was successfully managed at home on a new feature of non‐invasive ventilation called average volume assured pressure support (AVAPS) without the need for tracheostomy. The AVAPS feature enables the machine to deliver a consistent tidal volume by automatically adjusting the inspiratory pressure within a set range.ConclusionThe use of AVAPS feature in our case improved ventilation as indicated by a more stable gas exchange profile, making home non‐invasive ventilation a more practicable method of managing severe BPD in this infant.
Comparative study on the morphology and mechanical strength of induction welding joint of polyetheretherketone under different currents
Authors: Wang Feiyun , Ma Wanping , Zhan Xiaohong , Zhang Pingze , Bu Hengchang 
Published: September 2020

AbstractThere is an increasing need for joining technologies of polyetheretherketone (PEEK), in which induction welding technique is one of the most promising methods. The induction welding experiment of PEEK thin plates was conducted under different input currents in this research, while metal meshes were selected as induction components. The analysis of morphology, microstructure, and elemental composition of welding joints was performed by optical microscope (OM), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). Moreover, the mechanical strength of the induction‐welding joint was investigated by tensile test. The results indicate that the PEEK can be joined effectively when the metal mesh is selected as an induction component, and the welding joints with good appearance are formed under the appropriate process parameters. The more induced joule heat produced by the higher input current promotes the resin fusion at the interface, which is propitious to reduce the generation of defects. However, the excessive heat input results in the extreme melting and thermal decomposition of PEEK resin, which will deteriorate the morphology and property of the welding joints. When the input current is 5.2A, the induction‐welding joint can reach a maximum mechanical strength of 125.63 MPa, which increases by almost 60.55% through the optimization of welding parameters.
Registration of ‘GEORGIA‐19HP’ peanut
Authors: Branch W. D. , Brenneman T. B. 
Published: September 2020

Abstract‘Georgia‐19HP’ (Reg. no. CV‐141, PI 693908) is a new high‐yielding, high‐protein (HP), high‐oleic, Tomato spotted wilt virus (TSWV) resistant, root‐knot nematode (RKN) and leafspot resistant, virginia‐type peanut (Arachis hypogaea L. ssp. hypogaea var. hypogaea) cultivar released by the Georgia Agricultural Experiment Station in 2019. It was developed at the University of Georgia Coastal Plain Experiment Station, Tifton, GA. Georgia‐19HP originated from a cross made between an advanced Georgia breeding line, GA 072515 × ‘Tifguard’. Pedigree selection was practiced within the early segregating generations. Performance testing began in the F4:6 generation with the advanced pure‐line selection GA 132724, the experimental designation of Georgia‐19HP. During 3 yr (2016–2018) averaged across 30 tests at three locations in Georgia, Georgia‐19HP had significantly less TSWV and total disease incidence and higher pod yield, total sound mature kernels grade, and dollar value return per hectare than the widely popular virginia‐type cultivar ‘Bailey’. Georgia‐19HP was also found to have a similar percentage of extra large kernels but a smaller percentage of fancy pods compared with ‘Georgia‐11J’. Georgia‐19HP combines high yield, grade, and dollar value with TSWV resistance, leafspot resistance, RKN resistance, and the high‐protein and high‐oleic trait for longer shelf life and improved protein and oil quality of peanut and peanut products.
Reaction for the preparation of unique cyclic polysiloxanes with large size and narrow distribution
Authors: Ge Mengyuan , Li Guangwen , Ni Zibo , Liu Ning , Liu Yushan , Liu Yuzhou 
Published: September 2020

AbstractUtilizing collective forces between reactant and multiple catalyst molecules has been unprecedented due to the difficulty in realizing high order catalysis. Inspired by the power of collective forces in enzymes and organic catalysts, herein we report a rare example of high order catalysis for ring opening reaction (ROR) of strained rings by methanol. ROR is an important way to produce various polysiloxanes, but usually suffers from serious side reactions especially at high conversion, and currently there is a need to design new reaction pathway to achieve low molecular dispersity. In our study, the judiciously designed strained spiral cyclosiloxanes enable a high order catalysis by methanol, and this new methodology leads to a cyclic polysiloxane with high molecular weight and low dispersity even at full conversion of reactants. Kinetic study indicates an extremely unusual high‐order reaction involving multiple methanol molecules per reaction, also confirmed by quantum calculation which reveals the presence of zwitterionic ions stabilized by collecting force of hydrogen bonds by methanol molecules. The inherent driving force for this unusual phenomenon is dominated by enthalpy stabilization of the reactive intermediates through hydrogen bonding. The selective formation of SiOSi bonds, instead of silanol products, reflects the power of scientific design.
Thermal cross‐link between 2,5‐furandicarboxylic acid‐based polyimides and bismaleimide via Diels–Alder reaction
Authors: Ma Kai , Chen Guofei , Zhang Yonggang 
Published: September 2020

AbstractA series of cross‐linked polyimides (PIs) were prepared via two‐step solution polycondensation from 2,2‐bis[4‐(3,4‐dicarboxyphenoxy)phenyl]propane dianhydride (BPADA) and 2,5‐furandicarboxylic acid‐based diamines, N,N′‐bis(4‐amino‐2‐(trifluoromethyl)phenyl)furan‐2,5‐dicarboxamide (TFFDA) and N,N′‐bis(4‐aminophenyl)furan‐2,5‐dicarboxamide (p‐FDDA), followed by thermal crosslinking reaction with bismaleimide. The thermal crosslinking reaction and its mechanism were studied by FTIR spectra and model reaction analysis, which showed Diels–Alder reaction between furan group and maleimide group played a main role in the thermal treatment. The properties of cross‐linked PIs were characterized using dynamic mechanical thermal analysis, thermogravimetric analyses, tensile testing, ultraviolet‐visible spectra, and wide‐angle X‐ray diffraction. The cross‐linked polyimide film showed improved solvent‐resistance, thermal and mechanical properties with Tg values of 234–306oC, tensile strengths of 82–98 MPa and moduli of 2.3–3.0 GPa.
Persistent recovery of pancreatic function in patients with cystic fibrosis after ivacaftor
Authors: Munce Danielle , Lim Meerana , Akong Kathryn 
Published: September 2020

AbstractExocrine pancreatic insufficiency (EPI), which leads to malabsorption and poor weight gain, is seen in 85% of patients with cystic fibrosis (CF). EPI is treated with pancreatic enzyme replacement therapy taken with each meal. The highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator, ivacaftor, restores CFTR function in patients with responsive mutations. It is a widely held view that EPI in CF is irreversible due to the complete destruction of pancreatic ducts and acinar cells. We describe three pediatric CF patients with EPI who were started on ivacaftor, and subsequently showed evidence of restored exocrine pancreatic function with clinical and biochemical parameters.
Physiotherapy students' self‐assessment of performance—Are there gender differences in self‐assessment accuracy?
Authors: Støve Morten Pallisgaard 
Published: September 2020

AbstractBackground and PurposeThe ability to critically appraise one's performance is paramount in physiotherapy and, although there is a paucity of research in this area, factors such as gender have been suggested to moderate the self‐assessment accuracy of healthcare students. The purpose of this study was to determine a posteriori self‐assessment accuracy of first‐year physiotherapy students following a multiple‐choice anatomy examination and to determine the specific influence of gender as a potential moderator of self‐assessment accuracy.MethodOne‐hundred‐and‐forty‐two students (n = 72 female) enrolled in their second semester of a three‐and‐a‐half‐year physiotherapy programme participated in the study. A purpose‐made self‐assessment questionnaire was used to measure the students' self‐assessment ability, estimating their performance on 11 different anatomical categories following the examination. This was then compared with a criterion measure matched with the questionnaire. The accuracy of the students' self‐assessment was investigated by the relation between self‐assessment and objective performance.ResultsThe study showed low‐to‐moderate self‐assessment accuracy (rho ranging from 0.318 to 0.675) with the students underestimating their performance in six out of 11 categories (p < 0.019). Gender did not contribute significantly to differences in accuracy between students' self‐assessment and the criterion measure (p = 0.474).ConclusionAccording to the results, the students demonstrated low‐to‐moderate self‐assessment accuracy when compared to their performance. Notably, the results clearly showed that gender did not function as a moderator of self‐assessment accuracy among first‐year physiotherapy students.
Covid‐19.bioreproducibility.org: A web resource for SARS‐CoV‐2‐related structural models
Authors: Brzezinski Dariusz , Kowiel Marcin , Cooper David R. , Cymborowski Marcin , Grabowski Marek , Wlodawer Alexander , Dauter Zbigniew , Shabalin Ivan G. , Gilski Miroslaw , Rupp Bernhard , Jaskolski Mariusz , Minor Wladek 
Published: September 2020

AbstractThe COVID‐19 pandemic has triggered numerous scientific activities aimed at understanding the SARS‐CoV‐2 virus and ultimately developing treatments. Structural biologists have already determined hundreds of experimental X‐ray, cryo‐EM, and NMR structures of proteins and nucleic acids related to this coronavirus, and this number is still growing. To help biomedical researchers, who may not necessarily be experts in structural biology, navigate through the flood of structural models, we have created an online resource, covid19.bioreproducibility.org, that aggregates expert‐verified information about SARS‐CoV‐2‐related macromolecular models. In this article, we describe this web resource along with the suite of tools and methodologies used for assessing the structures presented therein.
An analysis of the trends, characteristics, scope, and performance of the Zimbabwean pharmacovigilance reporting scheme
Authors: Masuka Josiah Tatenda , Khoza Star 
Published: September 2020

AbstractWe aimed to determine the reporting trends and characteristics of Individual Case Safety Reports (ICSRs) from the Zimbabwean national pharmacovigilance system. ICSRs submitted to VigiBaseTM, the World Health Organisation's ICSR database between January 1993 and December 2017 were retrospectively reviewed with respect to the suspected medicine, System Organ Class (SOC), adverse drug reaction (ADR) type and seriousness, Anatomic Therapeutic Chemical (ATC) group, age, and gender. In total, 4071 ICSRs were submitted to VigiBaseTM from targeted spontaneous reporting (n = 2909; 71.5%), vaccine surveillance (n = 679; 16.7%), and passive spontaneous reporting (n = 483; 11.9%), respectively. The median age, ICSR completeness score and timeliness of reporting were 34.0 years (IQR: 14.0; 43.0), 0.90 (IQR: 0.70; 1.00), and 548.0 days (IQR: 266:1131), respectively. More than half of the ICRS were from female patients (n = 2233; 54.9%). Antiretrovirals, antibiotics, vaccines, and anti‐tubercular medicines were reported in 62.9%, 27.9%, 16.7%, and 13.3% of submitted ICSRs, respectively. The most frequent ADRs involved the skin and subcutaneous systems (n = 1111; 20.5%), nervous system (n = 733; 13.5%), and gastrointestinal disorders system (n = 654; 12.1%). The number of ADRs reported for each patient was significantly related to the reported medicine's ATC category (P = .001. The number of ADRs was significantly related to the use of antiretroviral agents. In conclusion, Zimbabwe has made significant progress in establishing a functional pharmacovigilance system. However, the present system reports on a limited therapeutic spectrum of medicines and potentially underestimates the national ADR burden. Further work is required to strengthen the more sustainable spontaneous reporting system which potentially captures a variety of therapeutic classes.
The spinosyns, spinosad, spinetoram, and synthetic spinosyn mimics ‐ discovery, exploration, and evolution of a natural product chemistry and the impact of computational tools
Authors: Sparks Thomas C , Crouse Gary D , Benko Zoltan , Demeter David , Giampietro Natalie C , Lambert William , Brown Annette V 
Published: September 2020

AbstractNatural products (NPs) have long been a source of insecticidal crop protection products. Like many macrolide NPs, the spinosyns originated from a soil inhibiting microorganism (Saccharopolyspora spinosa). More than 20 years after initial registration, the spinosyns remain a unique class of NP‐based insect control products that presently encompass two insecticidal active ingredients, spinosad, a naturally occurring mixture of spinosyns, and spinetoram, a semi‐synthetic spinosyn product. The exploration and exploitation of the spinosyns has, unusually, been tied to an array of computational tools including artificial intelligence (AI)‐based quantitative structure activity relationship (QSAR) and most recently computer‐aided modeling and design (CAMD). The AI‐based QSAR directly lead to the discovery of spinetoram, while the CAMD studies have recently resulted in the discovery and building of a series of synthetic spinosyn mimics. The most recent of these synthetic spinosyn mimics show promise as insecticides targeting lepidopteran insect pests as demonstrated by field studies wherein the efficacy has been shown to be comparable to spinosad and spinetoram. These and a range of other aspects related to the exploration of the spinosyns over the past 30 years are reviewed herein. © 2020 Society of Chemical Industry
Estimands in practice: Bridging the gap between study objectives and statistical analysis
Authors: Phillips Alan , Clark Tim 
Published: September 2020

SummaryThe International Council for Harmonisation (ICH) guideline E9 Statistical Principles for Clinical Trials (1) was issued in 1998. In October 2014, an addendum to ICH E9 was proposed on statistical principles relating to estimands and sensitivity analyses. The final version of the addendum to ICH E9 (R1) (2) was issued in November 2019. This virtual edition of Pharmaceutical Statistics takes a closer look at some of the progress that has been made since 2018 when implementing the estimand framework within clinical research. The articles discussed in this virtual issue are not new, but a compilation from previous issues. This specific article will act as a refresher for those not familiar with the topic and discuss the ABCs of estimands and their proposed deployment for improving the quality of clinical research. An overview of the more recent Pharmaceutical Statistics articles on estimands will be provided, signifying areas where progress have been made. The articles should be considered as contributions to the ongoing discussions rather than the final word. Finally, a personal perspective on the estimand success story and remaining challenges with proposed solutions will be discussed.