bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorus implantation of Mg-doped (Al)GaN heterostructures: structural examination and depth profiling
Authors: Piętak Karolina , Złotnik Sebastian , Rozbiegała Ewelina , Michałowski Paweł P. , Wójcik Marek , Gaca Jarosław , Rudziński Mariusz 
Published: September 2020

AbstractPhosphorus introduction into Mg-doped aluminium gallium nitride ((Al)GaN) epilayers to enhance the acceptor activation is a possible strategy for a p-type conductivity improvement in III-nitride wide-bandgap semiconductors. To date, P-implanted Mg-doped (Al)GaN structures have not been systematically evaluated, regarding structural verification and elemental distribution. Here, comprehensive studies of P ions impact on structural degradation are presented. Furthermore, a post-implantation annealing conducted at different temperatures is examined as well. The results demonstrated that the structural changes in the examined compounds, namely GaN and Al0.1Ga0.9N, due to P implantation and a subsequent recovery by thermal annealing follow similar trends. Interestingly, it was revealed that P diffusion length is higher in AlGaN than in GaN, possibly due to higher oxygen content in Al-containing compounds, analogous to Mg dopant. Additionally, the initial Mg concentration in (Al)GaN is crucial because too high Mg doping could be the main cause of electrical properties degradation of (Al)GaN heterostructures after P ion implantation.
Awful noises: evaluativism and the affective phenomenology of unpleasant auditory experience
Authors: Roberts Tom 
Published: September 2020

AbstractAccording to the evaluativist theory of bodily pain, the overall phenomenology of a painful experience is explained by attributing to it two types of representational content—an indicative content that represents bodily damage or disturbance, and an evaluative content that represents that condition as bad for the subject. This paper considers whether evaluativism can offer a suitable explanation of aversive auditory phenomenology—the experience ofawful noises—and argues that it can only do so by conceding that auditory evaluative content would be guilty of widespread error. Defending such an error-theory, moreover, comes with several explanatory costs.
The Big-M method with the numerical infinite M
Authors: Cococcioni Marco , Fiaschi Lorenzo 
Published: September 2020

AbstractLinear programming is a very well known and deeply applied field of optimization theory. One of its most famous and used algorithms is the so called Simplex algorithm, independently proposed by Kantorovič and Dantzig, between the end of the 30s and the end of the 40s. Even if extremely powerful, the Simplex algorithm suffers of one initialization issue: its starting point must be a feasible basic solution of the problem to solve. To overcome it, two approaches may be used: the two-phases method and the Big-M method, both presenting positive and negative aspects. In this work we aim to propose a non-Archimedean and non-parametric variant of the Big-M method, able to overcome the drawbacks of its classical counterpart (mainly, the difficulty in setting the right value for the constant M). We realized such extension by means of the novel computational methodology proposed by Sergeyev, known as Grossone Methodology. We have validated the new algorithm by testing it on three linear programming problems.
Two-machine flow shop with dynamic storage space
Authors: Berlińska Joanna , Kononov Alexander , Zinder Yakov 
Published: September 2020

AbstractThe publications on two-machine flow shop scheduling problems with job dependent storage requirements, where a job seizes a portion of the storage space for the entire duration of its processing, were motivated by various applications ranging from supply chains of mineral resources to multimedia systems. In contrast to the previous publications that assumed that the availability of the storage space remains unchanged, this paper is concerned with a more general case when the availability is a function of time. It strengthens the previously published result concerning the existence of an optimal permutation schedule, shows that the variable storage space availability leads to the NP-hardness in the strong sense even for unit processing times, and presents a polynomial-time approximation scheme together with several heuristic algorithms. The heuristics are evaluated by means of computational experiments.
ABVD and BEACOPP regimens’ effects on fertility in young males with Hodgkin lymphoma
Authors: Amin M. S. A. , Brunckhorst O. , Scott C. , Wrench D. , Gleeson M. , Kazmi M. , Ahmed K. 
Published: September 2020

Abstract
Purpose
Considering the increased cancer patient survivorship, the focus is now on addressing the impacts of treatment on quality of life. In young people, altered reproductive function is a major issue and its effects in young males are largely neglected by novel research. To improve clinician awareness, we systematically reviewed side effects of chemotherapy for Hodgkin lymphoma (HL) in young males.

Methods
The review was prospectively registered (PROSPERO N. CRD42019122868). Three databases (Medline via PUBMED, SCOPUS, and Cochrane Library) were searched for studies featuring males aged 13-51-years who underwent chemotherapy for HL using ABVD (Adriamycin® (doxorubicin), bleomycin, vinblastine, and dacarbazine) or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone) regimens. These chemotherapy regimens were compared against each other using sperm characteristics, FSH, and inhibin B levels to measure fertility levels.

Results
Data were extracted from five studies featuring 1344 patients. 6 months post-ABVD saw marked deterioration in sperm count, further reduced by more cycles (P = 0.05). Patients treated with BEACOPP rather than ABVD were more prone to oligospermia. Receiving fewer cycles of both regimens increased the likelihood of sperm production recovering. Patients treated with 6-8 cycles of BEACOPP did not recover spermiogenesis.

Conclusions
ABVD and BEACOPP regimens significantly reduce fertility function to varying effects depending on treatment duration. ABVD temporarily causes significant reductions in male fertility, whereas BEACOPP’s effects are more permanent. Therefore, clinicians should discuss fertility preservation with male patients receiving infertility-inducing gonadotoxic therapy. Further high-quality studies are required to more adequality describe the risk to fertility by chemotherapy.
Social health insurance in the Philippines: do the poor really benefit?
Authors: El Omari Salaheddine , Karasneh Mahmoud 
Published: September 2020

AbstractDeveloping countries have spent a tremendous amount of time and money on social health insurance programs to give the low-income population free access to health care services. Standard economic theory predicts that people use care services more frequently and regularly when they are free. In this paper, we show that providing free access to health services might not be enough to enhance the utilization of health care by indigents.
Novel & worthy: creativity as a thick epistemic concept
Authors: Sánchez-Dorado Julia 
Published: September 2020

AbstractThestandard viewin current philosophy of creativity says that being creative has two requirements: being novel and being valuable (to which a third intentionality requirement is often added; Sternberg and Lubart 1999; Boden 2004; Gaut 2010). Thestandard viewon creativity has recently become an object of critical scrutiny. Hills and Bird (2018) have specifically proposed to remove the value requirement from the definition, as it is not clear that creative objects are necessarily valuable or creative people necessarily praiseworthy. In this paper, I argue against Hills and Bird (2018), since eliminating the element of value from the explanation of creativity hinders the understanding of the role that creative products play in actual epistemic practices, which are fundamentally normative. More specifically, I argue that the terms ‘creativity’ and ‘creative’ function asthick epistemic conceptswhen employed by competent epistemic agents in practice, that is, these concepts have both a descriptive and an evaluative content that cannot be disentangled from one another. Accordingly, I suggest that philosophers should preferthick accountsoverthin accountsof creativity. A thick account of creativity is one that endorses thestandard viewat its basis, but further develops it in two ways: by stressing the entanglement of the value and novelty requirements; by permitting to encompass a range of domain-specific characterizations of such entanglement for different epistemic situations. In order to take the first steps in the development of such a thick account of creativity, I look at the domain of scientific practices as a case in point, and try to spell out what the thickness (or entanglement of novelty and worth) of creative instances typically entails here. Namely, I identify the worthy novelty of creative models and methods with their potential to clarify a tradition, with fruitfulness, and with the fulfilment of exploratory aims.
Evaluation of groundwater potential of bedrock aquifers in Geological Sheet 223 Ilorin, Nigeria, using geo-electric sounding
Authors: Raji W. O. , Abdulkadir K. A. 
Published: September 2020

AbstractElectrical resistivity data acquired in one hundred and ten (110) locations using vertical electrical sounding method of Schlumberger array have been used to study the hydrogeological properties and groundwater storage potential of bedrock aquifers in an area covered by Geological Sheet 223 Ilorin, Nigeria. The aim of the study was to identify productive aquifer zones for citing boreholes for community water supply. The data acquired were processed and interpreted using auxiliary curve matching and computer automation method to delineate the different geo-electric layers, their resistivities, thicknesses, and depths. Geo-electrical layers were interpreted to their equivalent geological layers using borehole lithological logs from the study area. Then, the hydraulic conductivity, transmissivity, fracture contrast, reflection coefficient were estimated and plotted in the form of 2D maps to describe the spatial variations of these parameters in the area. The results of the study revealed the presence of three to five geo-electric layers. The geo-electric layers, from top to the bottom, corresponds to the topsoil layer, lateritic layer, weathered rock layer, fractured rock layer, and the fresh basement rock. Lateritic and/or fractured rock layers were not delineated in some places. The weathered and fractured rock layers, where present, correspond to the aquifer units. The thickness of the fracture aquifer ranges from 0.6 to 33.6 m while the thickness of the weathered aquifer ranges from 1.4 to 49.3 m. The transmissivity, $$ T $$
T
, and hydraulic conductivity, $$ K $$
K
, range from 3 to 1200 m2/day and 1 to 48 m/day, respectively. The reflection coefficient and fracture contrast map showed the presence of water-bearing fractures and shared some similarities with T and K maps. A mathematical model for predicting groundwater potential, $$ {\text{GW}}_{\text{P}} $$

GW
P

, of weathered aquifer in the basement complex terrain was proposed in this study. The consistencies between the overall groundwater potential map and aquifers parameters distributions maps suggest the appropriateness of the proposed mathematical model for predicting groundwater potential of weathered rock in the basement complex area of Nigeria. The western, northwestern, and central parts of the study area, having $$ {\text{GW}}_{\text{P}} $$

GW
P

greater than 0.6 (60%), were recommended for groundwater development through boreholes drilled to a depth ranging between 75 and 100 m.
Stability of network centrality measures: a numerical study
Authors: Kardos Orsolya , London András , Vinkó Tamás 
Published: September 2020

AbstractIdentifying key actors or nodes in a network is a relevant task regarding many applications. In general, the real-valued function that evaluates the nodes is called node centrality measure. Performing a relevance-based ranking on the list of nodes is also of high practical importance, since the most central nodes by a measure usually provide the highest contribution in explaining the behavior of the whole network. Stability of centrality measures against graph perturbation is an important concept, especially in the analysis of real world—often noise contaminated—datasets from different domains. In this paper, with the utilization of the formal definition of stability introduced by Segarra and Ribeiro (IEEE Trans Signal Process 64(3):543–555, 2015), we discuss three main perturbation categories and experimentally analyze the stability of several node centrality measures.
Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling
Authors: Pozios Ioannis , Seel Nina N. , Hering Nina A. , Hartmann Lisa , Liu Verena , Camaj Peter , Müller Mario H. , Lee Lucas D. , Bruns Christiane J. , Kreis Martin E. , Seeliger Hendrik 
Published: September 2020

Abstract
Purpose
Currently, the exact role of estrogen receptor (ER) signaling in pancreatic cancer is unknown. Recently, we showed that expression of phosphorylated ERβ correlates with a poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here, we hypothesized that raloxifene, a FDA-approved selective ER modulator (SERM), may suppress PDAC tumor growth by interfering with ERβ signaling. To test this hypothesis, we studied the impact of raloxifene on interleukin-6/glycoprotein-130/signal transducer and activator of transcription-3 (IL-6/gp130/STAT3) signaling.

Methods
Human PDAC cell lines were exposed to raloxifene after which growth inhibition was assessed using a BrdU assay. ER knockdown was performed using siRNAs specific for ERα and ERβ. The effects of raloxifene on IL-6 expression and STAT3 phosphorylation in PDAC cells were assessed by ELISA and Western blotting, respectively. In addition, raloxifene was administered to an orthotopic PDAC tumor xenograft mouse model, after which tumor growth was monitored and immunohistochemistry was performed.

Results
Raloxifene inhibited the in vitro growth of PDAC cells, and this effect was reversed by siRNA-mediated knockdown of ERβ, but not of ERα, indicating ER isotype-specific signaling. We also found that treatment with raloxifene inhibited the release of IL-6 and suppressed the phosphorylation of STAT3Y705 in PDAC cells. In vivo, we found that orthotopic PDAC tumor growth, lymph node and liver metastases as well as Ki-67 expression were reduced in mice treated with raloxifene.

Conclusions
Inhibition of ERβ and the IL-6/gp130/STAT3 signaling pathway by raloxifene leads to potent reduction of PDAC growth in vitro and in vivo. Our results suggest that ERβ signaling and IL-6/gp130 interaction may serve as promising drug targets for pancreatic cancer and that raloxifene may serve as an attractive therapeutic option for PDAC patients expressing the ERβ isotype.
Impact of aeration and deaeration of switchable vacuum insulations on the overall heat conductivity using different core materials and filling gases
Authors: Erlbeck Lars , Sonnick S. , Wössner D. , Nirschl H. , Rädle M. 
Published: September 2020

AbstractInvestigating switchable vacuum insulation panels might lead to a new type of insulation, which can be switched on to enable a low heat flow when a good insulation effect is desired and switched off when exchange with the environment is requested, during a cold summer night, for example. For this reason, different core materials for vacuum insulations as typical silica powder were investigated as well as silica agglomerates and silica gel. These materials were checked for the necessary time of aeration and evacuation and the corresponding change of heat conductivity along with the change of gas-pressure. Silica gel in combination with helium as filling gas showed best results corresponding to a high difference of the heat conductivities evacuated and aerated. Beside the solid backbone structure of the silica gel, this is caused by the high heat conductivity and small kinetic atomic diameter of the helium gas. Silica agglomerates decreased the aeration time as well as the deaeration time, but the improvement was neglected because of a lower change of heat conductivity during pressure drop or rise. Nevertheless, a good switchable vacuum insulation can be produced using silica gel and helium, for example.
Technological characteristics of reject waters from aerobic sludge stabilization in small and medium-sized wastewater treatment plants with biological nutrient removal
Authors: Mucha Zbigniew , Mikosz Jerzy 
Published: September 2020

AbstractMost studies on the impact of reject waters recycled from sludge processing in the multi-phase activated sludge process focus on anaerobic sludge treatment in large wastewater treatment plants, leaving apart the processes of aerobic sludge stabilization often used in smaller facilities in rural and suburban areas. The article presents the results of tests carried out in three small and medium-sized wastewater treatment plants with biological removal of biogenic compounds that use aerobic stabilization to process sludge. The research concerned the quantity and quality of reject waters generated in the process of aerobic stabilization and dewatering of sewage sludge and their impact on the multi-phase activated sludge process. The results showed that the average volume of generated reject waters ranged from 3.2 to 5% of the incoming wastewater volume. The average share of organic compounds and total nitrogen loads contained in reject waters did not usually exceed 5–10% of the loads in raw wastewater but reached almost 50% in the case of total phosphorus. Studies indicated that the composition of the supernatant from aerobic stabilization is strongly dependent on the course of the process. The best quality was obtained for cyclic operation of the aerobic stabilization tank with 16 h of aeration and 8 h of settling. The results also showed the negative impact of sudden discharges of reject waters from sludge processing to a multi-phase biological reactor, which can be reduced by using an appropriate equalization tank and pretreatment of the side stream to reduce the recirculation of phosphorus.
Two-Stage Collaborative Exams have Little Impact on Subsequent Exam Performance in Undergraduate Mathematics
Authors: Kinnear George 
Published: September 2020

AbstractIn this paper, I investigate whether two-stage exams aid learning in undergraduate mathematics, as measured by students’ performance on subsequent exams. In a two-stage exam, students complete the exam individually then form into groups to solve it again, with grades based on a combination of the two stages. Previous research in other disciplines has found mixed results about their effect on subsequent performance, and little is known about their use in undergraduate mathematics. Here, I report on three studies which investigate the use of two-stage exams in different undergraduate mathematics contexts. The first two studies replicate observational methods from previous research, and find indications of a positive impact from group collaboration. The third study is experimental and finds that, in a delayed post-test, there is no difference in performance between students who answered related questions in a two-stage exam format and a control group which had no collaborative second stage. The findings suggest that two-stage exams may have little impact on longer-term learning of mathematics, but instructors may still wish to use them to emphasise a collaborative classroom pedagogy.
Performing Power in a Mystical Context: Implications for Theorizing Women's Agency
Authors: Akurugu Constance Awinpoka 
Published: September 2020

AbstractThis article builds on recent accounts of diffuse and complex agentic practices in the global South by drawing on ethnographic data gathered in northwestern Ghana among the Dagaaba. Contemporary feminist discourses and theories, particularly in contexts in the global South, have sought to draw attention to the multifaceted ways in which women exercise agency in these contexts. Practices that in the past were perceived as instruments of women's subordination or as re-inscribing their oppression have been re/interpreted as agentic. Agentic practices are theorized in more fluid terms than the binary pairing of agent/victim debates permit. Dagaaba contexts are deeply pervaded by beliefs in supernatural power forms, and these forces dis/empower certain forms of agentic acts. This article demonstrates that key factors combining with male power to regulate women's exercise of agency are perceived mystical forces. I argue that, in order not to risk missing agency—or rather “misdescribing” it—in the context of Dagaaba and most parts of sub-Saharan Africa, where the belief in mystical forces is profoundly pervasive, the role of these power forms as important determinants of the form that agentic practices assume—and more broadly, the way power works—needs critical attention in feminist theorizing.
Distorting Concepts, Obscured Experiences: Hermeneutical Injustice in Religious Trauma and Spiritual Violence
Authors: Panchuk Michelle 
Published: September 2020

AbstractThis article explores the relationship between hermeneutical injustice in religious settings and religious trauma (RT) and spiritual violence (SV). In it I characterize a form of hermeneutical injustice (HI) that arises when experiences are obscured from collective understanding by normatively laden concepts, and I argue that this form of HI often plays a central role in cases of religious trauma and spiritual violence, even those involving children. In section I, I introduce the reader to the phenomena of religious trauma and spiritual violence. In section II, I describe the role normatively laden concepts play in shaping our social experience. I then elucidate how they can contribute to HI. In section III, I provide a brief overview of the history of some significant identity prejudices in the history of Christianity and argue that children can properly be understood as victims of HI within some religious communities. I then return in section IV to the examples of religious trauma and spiritual violence offered throughout the article and demonstrate that HI plays an important causal role in each of them. HIs sometimes constitute spiritual and religious harms; at other times they create an epistemic environment conducive to spiritual abuse.
THE INTERNATIONAL ENDORSEMENT OF CORPORATE SETTLEMENTS IN FOREIGN BRIBERY CASES
Authors: Ivory Radha , Søreide Tina 
Published: September 2020

AbstractInternational anticorruption treaties create an almost universal requirement that States sanction legal persons for the crime of foreign bribery. However, the vast majority of corporate foreign bribery cases are ‘settled’ between governments and firms. Analysing key anticorruption instruments and treaty body reports, it appears there is a dearth of express rules on settlements in international law but a qualified implicit endorsement of domestic settlement laws and practices. The international regime is investigated in terms of its move towards common standards for the use of settlements, and whether recommendations are consistent with stated objectives. The analysis discloses an irony: States and international organisations fail to clearly articulate their expectations on settlements, while calling for transparent, effective and predictable domestic settlement rules.