bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of splenic MRC1hiMHCIIlo and MRC1loMHCIIhi cells from the monocyte/macrophage lineage of White Leghorn chickens
Authors: Yu Keesun , Gu Min Jeong , Pyung Young Jin , Song Ki-Duk , Park Tae Sub , Han Seung Hyun , Yun Cheol-Heui 
Published: May 2020

AbstractMonocytes/macrophages, which are found in a variety of organs, maintain tissue homeostasis at a steady state and act as the first line of defence during pathogen-induced inflammation in the host. Most monocyte/macrophage lineage studies in chickens have been largely performed using cell lines, while few studies using primary cells have been conducted. In the present study, the phenotypic and functional characteristics of splenic monocyte/macrophage lineage cells during steady state and inflammatory conditions were examined. Splenic monocyte/macrophage lineage cells could be identified as MRC1loMHCIIhiand MRC1hiMHCIIlocells based on their surface expression of MRC1 and MHCII. In the steady state, MRC1loMHCIIhicells were more frequently found among MRC1+cells. MRC1loMHCIIhicells expressed a higher number of antigen-presenting molecules (MHCII, MHCI, and CD80) than MRC1hiMHCIIlocells. In contrast, MRC1hiMHCIIlocells showed better phagocytic and CCR5-dependent migratory properties than MRC1loMHCIIhicells. Furthermore, MRC1hiMHCIIlocells infiltrated the spleen in vivo and then became MRC1loMHCIIhicells. During lipopolysaccharide (LPS)-induced inflammatory conditions that were produced via intraperitoneal (i.p.) injection, the proportion and absolute number of MRC1hiMHCIIlocells were increased in the spleen. Uniquely, inflammation induced the downregulation of MHCII expression in MRC1hiMHCIIlocells. The major source of inflammatory cytokines (IL-1β, IL-6, and IL-12) was MRC1loMHCIIhicells. Furthermore, MRC1hiMHCIIlocells showed greater bactericidal activity than MRC1loMHCIIhicells during LPS-induced inflammation. Collectively, these results suggest that two subsets of monocyte/macrophage lineage cells exist in the chicken spleen that have functional differences.
Existence and uniqueness for fuzzy differential equation with Hilfer–Katugampola fractional derivative
Authors: Chen Xingru , Gu Haibo , Wang Xingzhao 
Published: May 2020

AbstractIn this paper, we study a kind of fuzzy differential equation with Hilfer–Katugampola fractional derivative and nonlocal condition. By using successive approximation method, we obtain some sufficient conditions to ensure the existence and uniqueness of solution. An illustrative example is given to show the practical usefulness of the analytical results.
Asymptotically almost periodic solutions for certain differential equations with piecewise constant arguments
Authors: Feng Zonghong , Wang Yong , Ma Xin 
Published: May 2020

AbstractIt is well known that differential equations with piecewise constant arguments is a class of functional differential equations, which has fascinated many scholars in recent years. These delay differential equations have been successfully applied to diverse models in real life, especially in biology, physics, economics, etc. In this work, we are interested in the existence and uniqueness of asymptotically almost periodic solution for certain differential equation with piecewise constant arguments. Due to the particularity of the equations, we cannot use the traditional method to convert it into the difference equation with exponential dichotomy. Through constructing Cauchy matrix of the investigated system to find the corresponding Green matrix of the difference equation, we need the concept of exponential dichotomy and the Banach contraction fixed point theorem of the corresponding system. Then we give some sufficient conditions to obtain the existence and uniqueness of asymptotically almost periodic solutions for these systems.
Jindalrae and Gaenari numbers and polynomials in connection with Jindalrae–Stirling numbers
Authors: Kim Taekyun , Kim Dae San , Jang Lee-Chae , Lee Hyunseok 
Published: May 2020

AbstractThe aim of this paper is to study Jindalrae and Gaenari numbers and polynomials in connection with Jindalrae–Stirling numbers of the first and second kinds. For this purpose, we first introduce Jindalrae–Stirling numbers of the first and second kinds as extensions of the notions of the degenerate Stirling numbers of the first and second kinds, and deduce several relations involving those special numbers. Then we introduce Jindalrae and Gaenari numbers and polynomials and obtain some explicit expressions and identities associated with those numbers and polynomials. In addition, we interpret our results by using umbral calculus.
Existence theory and numerical analysis of three species prey–predator model under Mittag-Leffler power law
Authors: Abdo Mohammed S. , Panchal Satish K. , Shah Kamal , Abdeljawad Thabet 
Published: May 2020

AbstractIn this manuscript, the fractional Atangana–Baleanu–Caputo model of prey and predator is studied theoretically and numerically. The existence and Ulam–Hyers stability results are obtained by applying fixed point theory and nonlinear analysis. The approximation solutions for the considered model are discussed via the fractional Adams Bashforth method. Moreover, the behavior of the solution to the given model is explained by graphical representations through the numerical simulations. The obtained results play an important role in developing the theory of fractional analytical dynamic of many biological systems.
Construct and factorial validity of Neurobehavioral Disorder associated with Prenatal Alcohol Exposure (ND-PAE)
Authors: Sanders James Ladell , Netelenbos Nicole , Dei Samuel Ofori 
Published: May 2020

AbstractBackgroundND-PAE, as a condition needing further study, requires validation. Few studies have assessed the validity of ND-PAE with none using a prospective sample.MethodsFifty-eight children underwent multidisciplinary FASD assessments and were evaluated for ND-PAE using a prospective, clinical approach. Construct and factorial validity of ND-PAE were assessed, and associations between domains and symptoms described. Post hoc analysis assessed external validity of factors.ResultsND-PAE demonstrated weak construct validity with variable convergence and divergence within and between symptoms. Factor analysis revealed one strong factor consisting of abilities associated with adaptive behavior and general cognitive ability. Relative contribution of symptoms and domains were variable.ConclusionThis study provides an evidence-based approach to assessing ND-PAE symptoms and is a starting point to elucidating its neurobehavioral pattern.
MRI-guided percutaneous thermoablation in combination with hepatic resection as parenchyma-sparing approach in patients with primary and secondary hepatic malignancies: single center long-term experience
Authors: Winkelmann Moritz T. , Archid Rami , Gohla Georg , Hefferman Gerald , Kübler Jens , Weiss Jakob , Clasen Stephan , Nikolaou Konstantin , Nadalin Silvio , Hoffmann Rüdiger 
Published: May 2020

Abstract
Background
Combination therapy using hepatic resection (HR) and intra-operative thermal ablation is a treatment approach for patients with technically unresectable liver malignancies. The aim of this study was to investigate safety, survival and local recurrence rates for patients with technically unresectable liver tumors undergoing HR and separate percutaneous MR-guided thermoablation procedure as an alternative approach.

Methods
Data from all patients with primary or secondary hepatic malignancies treated at a single institution between 2004 and 2018 with combined HR and MR-guided percutaneous thermoablation was collected and retrospectively analyzed. Complications, procedure related information and patient characteristics were collected from institutional records. Overall survival and disease-free survival were estimated using the Kaplan-Meier method.

Results
A total of 31 patients (age: 62.8 ± 9.1 years; 10 female) with hepatocellular carcinoma (HCC; n = 7) or hepatic metastases (n = 24) were treated for 98 hepatic tumors. Fifty-six tumors (mean diameter 28.7 ± 23.0 mm) were resected. Forty-two tumors (15.1 ± 7.6 mm) were treated with MR-guided percutaneous ablation with a technical success rate of 100%. Local recurrence at the ablation site occurred in 7 cases (22.6%); none of these was an isolated local recurrence. Six of 17 patients (35.3%) treated for colorectal liver metastases developed local recurrence. Five patients developed recurrence at the resection site (16.1%). Non-local hepatic recurrence was observed in 18 cases (58.1%) and extrahepatic recurrence in 11 cases (35.5%) during follow-up (43.1 ± 26.4 months). Ten patients (32.3%) developed complications after HR requiring pharmacological or interventional treatment. No complication requiring therapy was observed after ablation. Median survival time was 44.0 ± 7.5 months with 1-,3-, 5-year overall survival rates of 93.5, 68.7 and 31.9%, respectively. The 1-, 3- and 5-year disease-free survival rates were 38.7, 19.4 and 9.7%, respectively.

Conclusion
The combination of HR and MR-guided thermoablation is a safe and effective approach in the treatment of technically unresectable hepatic tumors and can achieve long-term survival.
Use of simulation as a needs assessment to develop a focused team leader training curriculum for resuscitation teams
Authors: Zern Susan Coffey , Marshall William J. , Shewokis Patricia A. , Vest Michael T. 
Published: May 2020

AbstractBackgroundMany inpatients experience cardiac arrest and mortality in this population is extremely high. Simulation is frequently used to train code teams with the goal of improving these outcomes. A key step in designing such a training curriculum is to perform a needs assessment. We report on the effectiveness of a simulation-based training program for residents designed using unannounced in-situ simulation cardiac arrest data as a needs assessment.MethodsIn order to develop the curriculum for training, a needs assessment was done using in-situ simulation. Prior to instruction, residents were assessed in their ability to lead a simulated resuscitation using a standardized checklist. During the intervention phase, residents participated in didactic and team training. The didactic training consisted of pharmacology review, ACLS update and TeamSTEPPS training. Residents took turns as code team leader in three simulation sessions. Rapid cycle deliberate practice (RCDP) was employed as part of simulation sessions. All residents returned, for post-intervention assessment. Mean pre-post test scores were analyzed to determine if there was a significant difference.ResultsTwenty-seven residents participated. Mean pre-training assessment score was 47.6 (95% CI 37.5-57.9). The mean post-training assessment score was 84.4 (95% CI 79.0-89.5). The mean time to defibrillation after pads were placed in scenario with shockable rhythm decreased from 102.2 seconds (95% CI 74.0-130.5) to 56.3 (95% CI 32.7-79.8).ConclusionUsing unannounced in-situ cardiac arrest simulations as a needs assessment, a simulation-based training program was developed that significantly improved resident performance as team leader. Future work is needed to determine if this improvement translates into patient benefits and is sustainable. However, in-situ simulation is a promising tool for curriculum development.
Parental age at childbirth and children’s educational outcomes: evidence from upper-secondary schools in Italy
Authors: Cantalini Stefano , Guetto Raffaele , Panichella Nazareno 
Published: May 2020

AbstractIn the last decades, Western societies have been involved in huge demographic changes, amongst which one of the most important has been the increasing postponement of the transition to parenthood. This paper aims at analysing the consequences of later motherhood and fatherhood on children’s participation in upper-secondary schools in Italy, considering both the vertical and horizontal dimensions of education. It also aims at highlighting the role of father-mother age difference and heterogeneity in the effects by parental SES and birth order. Using Italian labour force survey data (2005-2014), results show that late parenthood is positively associated with educational attainment, whereas teenage and early parenthood negatively affect children’s educational outcomes, net of detailed information on parental SES. Age at parenthood affects the educational achievement mostly for children of low- and middle-educated parents, who are more penalized by early childbearing and more favoured by late parenthood than the offspring of the tertiary educated. Moreover, only children are less affected by age at parenthood, especially in comparison with later-born children. Finally, children’s educational outcomes are worse when the mother is older than the father, independently from the educational outcome considered, whereas they are better in case of parental age homogamy or when the father is slightly older than the mother.
How to use and assess qualitative research methods
Authors: Busetto Loraine , Wick Wolfgang , Gumbinger Christoph 
Published: May 2020

AbstractThis paper aims to provide an overview of the use and assessment of qualitative research methods in the health sciences. Qualitative research can be defined as the study of the nature of phenomena and is especially appropriate for answering questions of why something is (not) observed, assessing complex multi-component interventions, and focussing on intervention improvement. The most common methods of data collection are document study, (non-) participant observations, semi-structured interviews and focus groups. For data analysis, field-notes and audio-recordings are transcribed into protocols and transcripts, and coded using qualitative data management software. Criteria such as checklists, reflexivity, sampling strategies, piloting, co-coding, member-checking and stakeholder involvement can be used to enhance and assess the quality of the research conducted. Using qualitative in addition to quantitative designs will equip us with better tools to address a greater range of research problems, and to fill in blind spots in current neurological research and practice.
Report of two rare cases of adrenal incidentalomas with different origins: revisiting pathological and radiological findings with a short review of the literature
Authors: Elbaset M. A. , Zahran Mohamad H. , Badawy Mohamed , Elhameed M. Abd , Osman Yasser 
Published: May 2020

Abstract
Background
Adrenal tumors can be detected incidentally in 4 to 8% of patients radiologically. Adenomas, pheochromocytomas, and adrenocortical carcinomas represent the most common tumors of the adrenal glands. Rare histopathological findings are uncommon. We aimed to report two rare primary adrenal tumors diagnosed initially as incidentalomas to identify clinical characteristics, management, and clinical outcomes after treatment.

Case presentation
The first case was a 52-year-old man presented with an incidentally discovered locally advanced primary adrenal angiosarcoma. The patient was managed surgically with no adjuvant therapy. The patient was followed up for 3 years without evidence of local recurrence. The second case was a 63-year-old woman, presented with an incidentally discovered primary diffuse B-cell lymphoma of the left adrenal gland. She was treated by adrenalectomy. Later on, adjuvant six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy were given. After 6 months follow-up, the patient was alive and disease-free.

Conclusion
The diagnosis of adrenal tumors increased nowadays because of the widespread use of imaging studies, though rare pathologies should be taken into consideration.
ASCEND: Phase III, Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
Authors: Ghia Paolo , Pluta Andrzej , Wach Malgorzata , Lysak Daniel , Kozak Tomas , Simkovic Martin , Kaplan Polina , Kraychok Iryna , Illes Arpad , de la Serna Javier , Dolan Sean , Campbell Phillip , Musuraca Gerardo , Jacob Abraham , Avery Eric , Lee Jae Hoon , Liang Wei , Patel Priti , Quah Cheng , Jurczak Wojciech 
Published: May 2020

PURPOSE Acalabrutinib, a highly selective, potent, Bruton tyrosine kinase inhibitor, was evaluated in this global, multicenter, randomized, open-label, phase III study in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). METHODS Eligible patients, aged ≥ 18 years with R/R CLL, were randomly assigned 1:1 centrally and stratified by del(17p) status, Eastern Cooperative Oncology Group performance status score, and number of prior lines of therapy. Patients received acalabrutinib monotherapy or investigator’s choice (idelalisib plus rituximab [I-R] or bendamustine plus rituximab [B-R]). The primary end point was progression-free survival (PFS) assessed by an independent review committee (IRC) in the intent-to-treat population. Key secondary end points included IRC-assessed overall response rate, overall survival, and safety. RESULTS From February 21, 2017, to January 17, 2018, a total of 398 patients were assessed for eligibility; 310 patients were randomly assigned to acalabrutinib monotherapy (n = 155) or investigator’s choice (n = 155; I-R, n = 119; B-R, n = 36). Patients had received a median of two prior therapies (range, 1-10). After a median follow-up of 16.1 months (range, 0.03-22.4 months), median PFS was significantly longer with acalabrutinib monotherapy (PFS not reached) compared with investigator’s choice (16.5 months [95% CI, 14.0 to 17.1 months]; hazard ratio, 0.31 [95% CI, 0.20 to 0.49]; P < .0001). Estimated 12-month PFS was 88% (95% CI, 81% to 92%) for acalabrutinib and 68% (95% CI, 59% to 75%) for investigator’s choice. Serious adverse events occurred in 29% of patients (n = 44 of 154) treated with acalabrutinib monotherapy, 56% (n = 66 of 118) with I-R, and 26% (n = 9 of 35) with B-R. Deaths occurred in 10% (n = 15 of 154), 11% (n = 13 of 118), and 14% (n = 5 of 35) of patients receiving acalabrutinib monotherapy, I-R, and B-R, respectively. CONCLUSION Acalabrutinib significantly improved PFS compared with I-R or B-R and has an acceptable safety profile in patients with R/R CLL.
Rehearsing for Reconstruction: The Archipelagic Afterlives of the Port Royal Experiment
Authors: Carmody Todd 
Published: May 2020

AbstractThis essay traces the cultural legacy of the Port Royal Experiment, the Civil War–era social experiment in free labor conducted by Union forces on the Sea Islands of South Carolina and Georgia. Whereas literary and cultural historians typically focus on the “discovery” of slave spirituals by Northern missionaries and educators at Port Royal, this essay tracks how later writers, performers, and sociologists returned to the Sea Islands to reimagine the promise of free labor. The archive thus assembled includes Civil War–era ethnographies, memoirs, and reports; the scholarly monographs in UNC Press’s Social Study Series; and DuBose Heyward’s popular “Negro novel” Porgy (1925). Across this interdisciplinary tradition, writers of various stripes seek by turns to celebrate and contain the threat of the free but noncapitalist black body. The latter figure, recalling the disability category’s historical role in sorting people into work-based or need-based systems of social distribution, is commonly represented as disabled. Ultimately, the essay documents a dual development in US political economy as the marginalization of contraband slaves as capitalist laborers on the Sea Islands—the “failure” of the Port Royal Experiment—gives way to the consolidation of “black culture,” a success of a different kind.
Lost Archives, Lost Lands: Rereading New Mexico’s Imagined Environments
Authors: Nugent Carlos Alonso 
Published: May 2020

AbstractThis article describes how Nuevomexicanas/os have used texts, images, and other media to reclaim the lands they lost in the US-Mexico War. Along the way, it models a method for reading “imagined environments”—the frameworks through which human groups have represented, related to, and resided in their more-than-human worlds. This article focuses on two generations of writer-activists. In the 1930s, 1940s, and 1950s, Adelina Otero-Warren and Fabiola Cabeza de Baca situated themselves in the Precarious Desert, an imagined environment of constraints, contingencies, and struggles for survival. Then, in the 1960s and 1970s, the Alianza Federal de Mercedes revived the Pueblo Olvidado, an imagined environment saturated with laws, treaties, and cultural traditions. Despite many differences, both generations shared a desire to settle on and profit from Native lands. But though they never became environmentalists, they experimented with environmental writing and politics. By recovering these experiments, this article shows how media produce—rather than simply portray—lands and waters. Ultimately it tells the story of the borderlands as a series of struggles over what environments are, whom they can contain, and how they should be used.
Drinking alcohol as a way of coping with stress in students of medical faculties
Authors: Bryl Nadia , Czarnecka-Iwańczuk Marta , Romanowska Małgorzata , Stanisić Michał , Michalak Michał , Posadzy-Małaczyńska Anna 
Published: May 2020

Cel pracyZbadano związek stylu radzenia sobie ze stresem i motywacji do spożycia alkoholu
w kontekście ryzyka uzależnienia od alkoholu u studentów kierunków medycznych.MetodaBadaniem objęto 268 studentów kierunków medycznych W badaniach wykorzystano Test AUDIT (Alcohol Use Disorders Identyfication Test), Kwestionariusz Radzenia Sobie w Sytuacjach Stresowych (CISS), oraz autorską ankietę badającą poza danymi demograficznymi także motywację do picia alkoholu i sytuacje, w jakich badani sięgają po alkohol.WynikiW badanej grupie 94% osób spożywało alkohol w okresie ostatnich dwunastu miesięcy.
W badanej grupie 16% studentów kierunku medycznego i 20% studentów stomatologii pije w sposób ryzykowny lub szkodliwy. W 2% przypadków zaobserwowano duże ryzyko uzależnienia od alkoholu Ponad połowa respondentów sięga po alkohol w celu radzenia sobie ze stresem. Dane dotyczące stylu radzenia sobie ze stresem nie wykazują różnic istotnych statystycznie w zakresie głównego stylu radzenia sobie ze stresem: skoncentrowanego na zadaniu, skoncentrowanego na emocjach, skoncentrowanego na unikaniu. Studenci kierunku lekarskiego istotnie częściej niż studenci stomatologii radzili sobie ze stresem w sposób unikowy (poszukiwanie kontaktów towarzyskich). Nie wykazano istotnego związku między stylem radzenia sobie ze stresem, motywacją do picia i ryzykiem uzależniania od alkoholu.WnioskiBrak związków między badanymi zmiennymi może wskazywać na stosowanie przez badanych innych czynności niż sięganie po alkohol w radzeniu sobie ze stresem. Ważna jest profilaktyka i stworzenie warunków sprzyjających rozwojowi strategii radzenia sobie ze stresem w grupie studentów kierunków medycznych.
Allocating Resources with Nonmonotonic Returns
Authors: Baiman Stanley , Heinle Mirko S. , Saouma Richard 
Published: May 2020

The literature on resource allocation under adverse selection has focused on models in which the resource being allocated is such that the privately informed agent always prefers more of it to less. We analyze a firm’s optimal resource allocation mechanism when this assumption does not hold and show that the resulting mechanism has a number of novel characteristics. For example, first best may be achievable even with nontrivial information asymmetry; when first best cannot be achieved, it is always optimal to overinvest relative to first best, and the most efficient agent may not earn rents, even when a less efficient agent does. This paper was accepted by Suraj Srinivasan, accounting.