bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate Effect of Ankle Mobilization on Range of Motion, Dynamic Knee Valgus, and Knee Pain in Women With Patellofemoral Pain and Ankle Dorsiflexion Restriction: A Randomized Controlled Trial With 48-Hour Follow-Up
Authors: Coelho Bruno Augusto Lima , Rodrigues Helena Larissa das Neves , Almeida Gabriel Peixoto Leão , João Sílvia Maria Amado 
Published: December 2020

Context: Restriction in ankle dorsiflexion range of motion (ROM) has been previously associated with excessive dynamic knee valgus. This, in turn, has been correlated with knee pain in women with patellofemoral pain. Objectives: To investigate the immediate effect of 3 ankle mobilization techniques on dorsiflexion ROM, dynamic knee valgus, knee pain, and patient perceptions of improvement in women with patellofemoral pain and ankle dorsiflexion restriction. Design: Randomized controlled trial with 3 arms. Setting: Biomechanics laboratory. Participants: A total of 117 women with patellofemoral pain who display ankle dorsiflexion restriction were divided into 3 groups: ankle mobilization with anterior tibia glide (n = 39), ankle mobilization with posterior tibia glide (n = 39), and ankle mobilization with anterior and posterior tibia glide (n = 39). Intervention(s): The participants received a single session of ankle mobilization with movement technique. Main Outcome Measures: Dorsiflexion ROM (weight-bearing lunge test), dynamic knee valgus (frontal plane projection angle), knee pain (numeric pain rating scale), and patient perceptions of improvement (global perceived effect scale). The outcome measures were collected at the baseline, immediate postintervention (immediate reassessment), and 48 hours postintervention (48 h reassessment). Results: There were no significant differences between the 3 treatment groups regarding dorsiflexion ROM and patient perceptions of improvement. Compared with mobilization with anterior and posterior tibia glide, mobilization with anterior tibia glide promoted greater increase in dynamic knee valgus (P = .02) and greater knee pain reduction (P = .02) at immediate reassessment. Also compared with mobilization with anterior and posterior tibia glide, mobilization with posterior tibia glide promoted greater knee pain reduction (P < .01) at immediate reassessment. Conclusion: In our sample, the direction of the tibia glide in ankle mobilization accounted for significant changes only in dynamic knee valgus and knee pain in the immediate reassessment.
Reducing redundant creatine kinase testing in cardiac injury
Authors: Raza Sheharyar , Amaral Andre C , Pang Jeffrey , Moussa Fuad , Shelton Dominick , Notario Lowyl , Harrington Heather , Callum Jeannie L , Yip Paul M 
Published: December 2020

BackgroundCreatine kinase (CK) testing in the setting of suspected cardiac injury is commonly performed yet rarely provides clinical value beyond troponin testing. We sought to evaluate and reduce CK testing coupled with troponin testing by 50% or greater.MethodsWe performed root cause analysis to study prevailing processes and patterns of CK testing. We developed new institutional guidelines, removed CK from high-volume paper and electronic order bundles and conducted academic detailing for departments with highest ordering frequency. We evaluated consecutive patients at Sunnybrook Health Sciences Centre between 1 January 2018 and 31 March 2020 who had either a CK or troponin level measured. We prespecified successful implementation as a reduction of 50% in total CK orders and a decrease in the ratio of CK-to-troponin tests to one-third or less. We retained additional data beyond our study period to assess for sustained reductions in testing.ResultsTotal CK tests decreased over the study period from 3963 to 2111 per month, amounting to a 46.7% reduction (95% CI 33.2 to 60.2; p<0.001) equalling 61 fewer tests per hospital day. Troponin testing did not significantly change during the intervention. Ratio of CK-to-troponin tests decreased from 0.91 to 0.49 (p<0.001). The reduction coincided with changes to order-sets, was observed across all clinical units and was sustained during additional months beyond the study period. These reductions in testing resulted in a projected annual cost savings of C$28 446.ConclusionsWe demonstrate that a low-cost and feasible quality improvement initiative may lead to significant reduction in unnecessary CK testing and substantial savings in healthcare costs for patients with suspected cardiac injury.
Catheter-related complications and mortality of atrial fibrillation ablation following introduction of contact force-sensing technology
Authors: Akar Joseph G , Hummel James P , Yao Xiaoxi , Sangaralingham Lindsey , Dhruva Sanket , Dong Jun , Ward Rebecca , Shah Nilay D , Ross Joseph , Noseworthy Peter A 
Published: December 2020

ObjectivesContact force-sensing catheters allow real-time catheter-tissue contact force monitoring during atrial fibrillation. These catheters were rapidly adopted into clinical practice following market introduction in 2014, but concerns have been raised regarding collateral damage such as esophageal injury. We sought to examine whether the introduction of force-sensing catheters was associated with a change in short-term and intermediate-term acute care use, complications and mortality following atrial fibrillation ablation.DesignRetrospective cohort analysis. We used inverse probability treatment weight matching to account for the differences in baseline characteristics between groups.SettingWe examined patients included in the OptumLabs Data Warehouse who underwent ablation for atrial fibrillation before (2011–2013) and after (2015–2017) the market introduction of contact force-sensing catheters.Main outcome measuresWe examined 30-day and 90-day rates of all-cause acute care use, including hospitalizations and emergency department visits, as well as death and hospitalization for catheter-related complications, including atrioesophageal fistula, pericarditis, cardiac tamponade/perforation and stroke/transient ischemic attack.ResultsOur sample included 3470 and 5772 patients who underwent atrial fibrillation (AF) ablation before and after market introduction of contact force-sensing catheters, respectively. Complication rates were low and did not differ between the two periods (p>0.10 for each outcome). The 30-day and 90-day mortality was 0.1% and 0.3%, respectively after market introduction and unchanged from prior to 2014. The 90-day rates of all-cause acute care use decreased, from 27.0% in 2011–2013 to 23.9% in 2015–2017 (p<0.001).ConclusionsAF ablation-related catheter complications and mortality are low and there has been no significant change following the introduction of force-sensing catheters.
The growth factor parametrization versus numerical solutions in flat and non-flat dark energy models
Authors: Velasquez-Toribio A. M. , Fabris Júlio C. 
Published: December 2020

AbstractIn the present investigation we use observational data of $$ f \sigma _ {8} $$

f

σ
8

to determine observational constraints in the plane $$(\Omega _{m0},\sigma _{8})$$

(

Ω

m
0

,

σ
8

)

using two different methods: the growth factor parametrization and the numerical solutions method for density contrast, $$\delta _{m}$$

δ
m

. We verified the correspondence between both methods for three models of accelerated expansion: the $$\Lambda CDM$$

Λ
C
D
M

model, the $$ w_{0}w_{a} CDM$$

w
0

w
a

C
D
M

model and the running cosmological constant RCC model. In all case we consider also the curvature as free parameter. The study of this correspondence is important because the growth factor parametrization method is frequently used to discriminate between competitive models. Our results we allow us to determine that there is a good correspondence between the observational constrains using both methods. We also test the power of the $$ f\sigma _ {8} $$

f

σ
8

data to constraints the curvature parameter within the $$ \Lambda CDM $$

Λ
C
D
M

model. For this we use a non-parametric reconstruction using Gaussian processes. Our results show that the $$ f\sigma _ {8}$$

f

σ
8

data with the current precision level does not allow to distinguish between a flat and non-flat universe.
Demise of Unruh radiation
Authors: O’Connell R. F. 
Published: December 2020

Unruh radiation has attracted much interest, particularly because of its relationship to Hawking radiation. But its existence has been challenged by a variety of authors, including ourselves [Phys. Lett. A 158, 31 (1991)]. The absence of a consensus may be traced to the complex challenge of dealing with the infinite number of particles of the associated heat bath. Here, we show how this problem may be obviated by using the quantum Langevin equation [Ford et al., Phys. Rev. A 37, 4419 (1988); J. Math. Phys. 6, 504 (1965)], which enables us to present a simple argument to show that, despite the existence of an Unruh temperature, there is no Unruh radiation. A key point is that the Unruh system is an equilibrium system, in contrast to the Hawking system which is a non-equilibrium system.
Implementation of the CMS-SUS-19-006 analysis in the MadAnalysis 5 framework (supersymmetry with large hadronic activity and missing transverse energy; 137 fb−1)
Authors: Mrowietz Malte , Bein Sam , Sonneveld Jory 
Published: December 2020

We present the MadAnalysis 5 implementation and validation of the analysis Search for supersymmetry in proton-proton collisions at 13 TeV in final states with jets and missing transverse momentum (CMS-SUS-19-006). The search targets signatures with at least two jets and large missing transverse momentum in the all-hadronic final state. The analyzed luminosity is 137 fb[Formula: see text], corresponding to the Run 2 proton-proton data set recorded by the CMS detector at 13 TeV. This implementation has been validated in a variety of simplified models, by comparing derived cut flow tables and histograms with information provided by the CMS collaboration, using event samples that we simulated for the purpose of this re-implementation study. The validation is found to reproduce the signal acceptance in most cases.
Implementation of the ATLAS-SUSY-2018-31 analysis in the MadAnalysis 5 framework (sbottoms with multi-bottoms and missing transverse energy; 139 fb−1)
Authors: Araz Jack Y. , Fuks Benjamin 
Published: December 2020

We present the implementation, in the MadAnalysis 5 framework, of the ATLAS-SUSY-2018-31 search for new physics, and document the validation of this implementation. This analysis targets, with 139 fb[Formula: see text] of proton–proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector between 2015 and 2018, the production of a pair of supersymmetric bottom squarks when they further decay through a cascade decay involving the second lightest neutralino and a Standard Model Higgs boson. The validation of our work is based on three benchmark scenarios targeting different kinematic configurations. The first of them considers a new physics spectrum leading to the presence of high-[Formula: see text] [Formula: see text]-jets originating from sbottom decays, whereas the last two, that differ by the neutralino mass spectrum, are dedicated to the compressed regime and thus yield the presence of soft [Formula: see text]-jets in the final state. We obtain an agreement between the MadAnalysis 5 predictions and the official ATLAS results at the level of 20–30%, the largest discrepancies being related to cases exhibiting a poor Monte Carlo numerical precision at the level of the official ATLAS results.
On the parity of the number of partitions with odd multiplicities
Authors: Sellers James A. , Zanello Fabrizio 
Published: December 2020

Recently, Hirschhorn and the first author considered the parity of the function [Formula: see text] which counts the number of integer partitions of [Formula: see text] wherein each part appears with odd multiplicity. They derived an effective characterization of the parity of [Formula: see text] based solely on properties of [Formula: see text] In this paper, we quickly reprove their result, and then extend it to an explicit characterization of the parity of [Formula: see text] for all [Formula: see text] We also exhibit some infinite families of congruences modulo 2 which follow from these characterizations. We conclude by discussing the case [Formula: see text], where, interestingly, the behavior of [Formula: see text] modulo 2 appears to be entirely different. In particular, we conjecture that, asymptotically, [Formula: see text] is odd precisely [Formula: see text] of the time. This conjecture, whose broad generalization to the context of eta-quotients will be the topic of a subsequent paper, remains wide open.
Final Results of the Prospective Biomarker Trial PETra: [11C]-MET-Accumulation in Postoperative PET/MRI Predicts Outcome after Radiochemotherapy in Glioblastoma
Authors: Seidlitz Annekatrin , Beuthien-Baumann Bettina , Löck Steffen , Jentsch Christina , Platzek Ivan , Zöphel Klaus , Linge Annett , Kotzerke Jörg , Petr Jan , van den Hoff Jörg , Steinbach Jörg , Krex Dietmar , Schmitz-Schackert Gabriele , Falk Monique , Baumann Michael , Krause Mechthild 
Published: December 2020

Abstract

Purpose:
This prospective trial investigates the association of time to recurrence (TTR) in glioblastoma with [11C]methionine (MET) tracer uptake before postoperative radiochemotherapy (RCT) aiming to guide radiotherapy boost regions.

Experimental Design:
Between 2013 and 2016, 102 patients with glioblastoma were recruited. RCT was performed with concurrent and adjuvant temozolomide to a total dose of 60 Gy. Tumor residues in postresection PET and MRI were together defined as gross tumor volumes for radiotherapy treatment planning. [11C]methionine (MET)-PET/MRI was performed before RCT and at each follow-up.

Results:
The primary hypothesis of a longer TTR for patients without increased tracer accumulation in postoperative MET-PET was confirmed in 89 patients. With 18.9 months (95% confidence interval, 9.3–28.5 months), median TTR was significantly (P &lt; 0.001) longer for patients without (n = 29, 32.6%) as compared with 6.3 months (3.6–8.9) for patients with MET accumulation (n = 60, 67.4%) in pre-RCT PET. Although MRI often did not detect all PET-positive regions, an unfavorable impact of residual tumor in postsurgical MRI (n = 38, 42.7%) on TTR was observed [4.6 (4.2–5.1) vs. 15.5 months (6.0–24.9), P &lt; 0.001]. Significant multivariable predictors for TTR were MRI positivity, PET-positive volume, and O6-methylguanine DNA methyltransferase (MGMT) hypermethylation.

Conclusions:
Postsurgical amino acid PET has prognostic value for TTR after RCT in glioblastoma. Because of the added value of the metabolic beyond the pure structural information, it should complement MRI in radiotherapy planning if available with reasonable effort, at least in the context of maximal therapy. Furthermore, the spatial correlation of regions of recurrence with PET-positive volumes could provide a bioimaging basis for further trials, for example, testing local radiation dose escalation.
Prendre en charge l’enseignement moral et civique
Authors: Fix-Lemaire Séverine 
Published: December 2020

Cette recherche, basée sur une construction de cas, pose un regard orienté par la psychanalyse sur l’enseignement, dans le 1er degré en France, d’une discipline nouvelle dans sa forme mais historiquement ancrée dans l’École française : l’enseignement moral et civique. La nature des savoirs mis en jeu semble provoquer un dilemme subjectif qui place des professeurs des écoles entre prescription institutionnelle et désir d’enseigner, entre acte et inhibition. Dès lors, il s’agit de se demander quelles causes subjectives provoquent un embarras pour un professeur des écoles d’en passer par l’acte éducatif en enseignement moral et civique.
L’analyse interprétative de paroles d’une professeure des écoles montre que cet enseignement semble placer le sujet face à quelque chose de lui difficile voire impossible à supporter en partie parce que cela l’oblige à en passer par un acte d’éducation qui le dévoile aux autres et à lui-même. L'EMC serait alors à lire en tant que « rapport à l’épreuve » (Brossais & Jourdan, 2011), concept permettant de rendre compte d'un rapport au savoir particulier.
Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study
Authors: Corlin Laura , Liu Chunyu , Lin Honghuang , Leone Dominick , Yang Qiong , Ngo Debby , Levy Daniel , Cupples L. Adrienne , Gerszten Robert E. , Larson Martin G. , Vasan Ramachandran S. 
Published: December 2020

Background
Proteomic biomarkers related to cardiovascular disease risk factors may offer insights into the pathogenesis of cardiovascular disease. We investigated whether modifiable lifestyle risk factors for cardiovascular disease are associated with distinctive proteomic signatures.

Methods and Results

We analyzed 1305 circulating plasma proteomic biomarkers (assayed using the SomaLogic platform) in 897 FHS (Framingham Heart Study) Generation 3 participants (mean age 46±8 years; 56% women; discovery sample) and 1121 FOS (Framingham Offspring Study) participants (mean age 52 years; 54% women; validation sample). Participants were free of hypertension, diabetes mellitus, and clinical cardiovascular disease. We used linear mixed effects models (adjusting for age, sex, body mass index, and family structure) to relate levels of each inverse‐log transformed protein to 3 lifestyle factors (ie, smoking, alcohol consumption, and physical activity). A Bonferroni‐adjusted
P
value indicated statistical significance (based on number of proteins and traits tested,
P
<4.2×10
−6
in the discovery sample;
P
<6.85×10
−4
in the validation sample). We observed statistically significant associations of 60 proteins with smoking (37/40 top proteins validated in FOS), 30 proteins with alcohol consumption (23/30 proteins validated), and 5 proteins with physical activity (2/3 proteins associated with the physical activity index validated). We assessed the associations of protein concentrations with previously identified genetic variants (protein quantitative trait loci) linked to lifestyle‐related disease traits in the genome‐wide‐association study catalogue. The protein quantitative trait loci were associated with coronary artery disease, inflammation, and age‐related mortality.

Conclusions
Our cross‐sectional study from a community‐based sample elucidated distinctive sets of proteins associated with 3 key lifestyle factors.
Excess Mortality and Undertreatment of Women With Severe Aortic Stenosis
Authors: Tribouilloy Christophe , Bohbot Yohann , Rusinaru Dan , Belkhir Khadija , Diouf Momar , Altes Alexandre , Delpierre Quentin , Serbout Saousan , Kubala Maciej , Levy Franck , Maréchaux Sylvestre , Enriquez Sarano Maurice 
Published: December 2020

Background
Although women represent half of the population burden of aortic stenosis (AS), little is known whether sex affects the presentation, management, and outcome of patients with AS.

Methods and Results

In a cohort of 2429 patients with severe AS (49.5% women) we aimed to evaluate 5‐year excess mortality and performance of aortic valve replacement (AVR) stratified by sex. At presentation, women were older (
P
<0.001), with less comorbidities (
P
=0.030) and more often symptomatic (
P
=0.007) than men. Women had smaller aortic valve area (
P
<0.001) than men but similar mean transaortic pressure gradient (
P
=0.18). The 5‐year survival was lower compared with expected survival, especially for women (62±2% versus 71% for women and 69±1% versus 71% for men). Despite longer life expectancy in women than men, women had lower 5‐year survival than men (66±2% [expected‐75%] versus 68±2% [expected‐70%],
P
<0.001) after matching for age. Overall, 5‐year AVR incidence was 79±2% for men versus 70±2% for women (
P
<0.001) with male sex being independently associated with more frequent early AVR performance (odds ratio, 1.49; 1.18–1.97). After age matching, women remained more often symptomatic (
P
=0.004) but also displayed lower AVR use (64.4% versus 69.1%;
P
=0.018).

Conclusions
Women with severe AS are diagnosed at later ages and have more symptoms than men. Despite prevalent symptoms, AVR is less often performed in women and 5‐year excess mortality is noted in women versus men, even after age matching. These imbalances should be addressed to ensure that both sexes receive equivalent care for severe AS.
Von der Resektionsprothetik zur freien Knochenplastik
Authors: Sigron Guido 
Published: December 2020

Die vorliegende Arbeit untersucht die Entwicklung zahnärztlicher und chirurgischer Methoden zur Wiederherstellung der Unterkieferkontinuität nach Knochenverlust.
Ausgehend von der zahnärztlichen Resektionsprothetik werden wichtige Etappen zur Knochentransplantation am Unterkiefer aufgezeigt. Bis 1914 konnte kein sicheres Transplantationskonzept erarbeitet werden. Erst die Zusammenarbeit zwischen Chirurgen und Zahnärzten im Ersten Weltkrieg schuf die Grundlagen für den Durchbruch der Knochenplastik am Unterkiefer.
La Faculté de médecine de l'Université de Lausanne (1890) : un pari politique
Authors: Saudan Guy 
Published: December 2020

La creation de la Faculté de médecine de l’Université de Lausanne relève davantage de sollicitations politiques que médicales: la souveraineté cantonale autorise le projet d'une école, en 1804, et le fédéralisme vaudois provoque sa realisation, en 1890.
Dans le dernier quart du XIXe siècle, Lausanne doit se tailler sa place entre Herne, la puissance patricienne prornue capitale federate, et l'industrieuse Genève. Le débat cristallise autour du tracé des chemins defer et de la localisation des études supérieures; le chef-lieu vaudois sera carrefour ferroviaire et ville universitaire. Les libéraux sécularisent l'Académie et les radicauxy font pénétrer les sciences. Uouverture d'une Faculté de médecine a Genève (1876) et finstitu-tion d’examens fédéraux (1877) font office de catalyseurs: précédée dhm ensei-gnement propédeutique (1881), une Faculté complete de médecine voit lejour â Lausanne, permettant la transformation de Vancienne Académie en Université (1890).
Die Beziehungen Theodor Kochers zur «Société internationale de chirurgie»
Authors: Liebermann-Meffert Dorothea , Allgöwer Martin , Rüedi Thomas 
Published: December 2020

Mit dem Ziel, dem Fortschritt in der Chirurgie durch freundschaftlichen Erfah-rungsaustausch zu dienen, wurde im Jahre 1902 in Brüssel über die engen Grenzen nationalen Denkens hinweg die erste internationale Gesellschaft für Chirurgie gegründet. Als 1905 der erste Kongress stattfand, hatte die «Société Internationale de Chirurgie» (SIC) oder «International Society of Surgery» (ISS) bereits 638 Mitglieder; unter ihnen ivaren die bedeutendsten Chirurgen aus aller Veit.
Theodor Kocher stand diesem Kongress als Präsident vor und war für seine Thematik verantwortlich. Seine Präsidialrede spiegelt die Ideale der Gesellschaft deutlich wieder. Die persönliche und fachliche Autorität Kochers, sein wissenschaftliches Konzept, das er so gerne seinen Kollegen weitervermittelte, und sein in ternationales Denken prägten die junge Gesellschaft, in deren Vorstand er bis zu seinem Tod 1917 blieb.