bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining sexuality in later life: A systematic review
Authors: Macleod Ashley , McCabe Marita P. 
Published: June 2020

AbstractObjectiveTo identify whether a consistent definition of sexuality is used across research articles to describe sexuality in later life for heterosexual men and women.MethodsA systematic review was conducted that examined how researchers define sexuality for heterosexual adults. Peer‐reviewed journal articles on sexuality published between 1999 and 2018 were examined for the presence of sexuality definitions. Sexuality themes discussed in each article were recorded, and results were tabulated.ResultsFew articles explicitly provide a definition of 'sexuality' as it pertains to later life. Definitions from articles that defined sexuality explicitly were inconsistent across studies. Topics included in implicit and explicit definitions of sexuality were disparate across studies and included a diverse range of sexuality dimensions.ConclusionGreater consistency is needed in how “sexuality” in later life is defined across studies and should be informed by data so that it accurately reflects the sexual experiences of older adults.
Sexuality and ageing in palliative care environments? Breaking the (triple) taboo
Authors: Malta Sue , Wallach Isabelle 
Published: June 2020

BackgroundAgeist perceptions continue to constrain the choices available to older adults in terms of their sexual expression.ObjectiveThis paper discusses the last stage of life, when older adults may be progressing through a terminal disease, dying and in palliative care environments. Are they (or is anyone, at any age) interested in remaining intimate when they are dying? If yes, how is this interest accepted/facilitated within such environments?.ResultsThis article does not claim to be definitive, but provides a broad, preliminary sketch of this neglected research area. It suggests that, for many, sexual expression and intimate connection continue to be important until the very end of the lifespan.ConclusionsAs such, this important topic deserves recognition as part of an overall response to sexuality and ageing by policy makers and health professionals. Its importance will only become more significant due to greater longevity and population ageing.
An overview of sexual behaviour research in later life—Quantitative and qualitative findings
Authors: Freak‐Poli Rosanne , Malta Sue 
Published: June 2020

AbstractAimThis article provides an overview of current sexual behaviour research in later life by describing associated factors, including the physical and psychological benefits.MethodsRecent systematic reviews were interrogated for findings on sexual behaviour research in adults aged 60+.ResultsRegardless of research methods employed, all studies showed that there were a range of physical and psychological benefits to remaining sexually active in later life. While quantitative studies placed an emphasis on measuring penile‐vaginal intercourse, they provided no definitive conclusion about the benefits due to ‘inconsistent results’ across studies. Qualitative studies described the myriad ways in which older adults redefine what constitutes sexual activity despite the onset of dysfunction and disability.ConclusionWhile the different research methods show that engaging in sexual behaviour has physical and psychological benefits at all adult ages, there is limited conclusive evidence about what the overall benefits might be in later life.
It's not age that prevents sexual activity later in life
Authors: Freak‐Poli Rosanne 
Published: June 2020

AbstractObjectiveTo describe key factors that facilitate sexual behaviour in later life.MethodsRe‐analysis of data from a study of 2,374 Dutch older adults.ResultsPartner availability, gender and health are likely to be more important factors influencing sexual behaviour engagement than the factor of age in later life. Lack of partner availability, traditional gender roles and poor health are associated with older age. However, current generations of older adults will be more capable, less ashamed of their sexual desires and engage in more sexual behaviour than prior generations.ConclusionThis analysis observed that sexual activity is associated with partner availability and better health, rather than age, countering stereotypes of decline in sexual behaviour and normalising sexual activity and desire in later life.
Intralipid treatment for women with reproductive failures
Authors: Coulam Carolyn B. 
Published: June 2020

AbstractDoes intravenous intralipid treatment for reproductive failure enhance live births? The answer to this question is yes, BUT only in patients that have a diagnosis of recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL) loss AND demonstrate elevated NK (natural killer) cell density in their endometrial biopsy. Live birth rates have been reported between 33% and 42% among women displaying elevated NK activity with a diagnosis of RIF and 75% and 91% among women experiencing RPL after intralipid infusion. When the pregnancy outcomes of women with a history of reproductive failure and elevated NK cells treated with intralipid were evaluated, the overall live birth rate per cycle of treatment was 61%. The results of published studies suggest that intralipid can be used successfully as a therapeutic option to modulate abnormal NK activity in women with reproductive problems.
Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome
Authors: Malmin Agni , Syre Heidi , Ushakova Anastasia , Utheim Tor Paaske , Forsaa Vegard Asgeir 
Published: June 2020

AbstractPurposeTo review the incidence, aetiology and outcomes of endophthalmitis during a 20‐year period in a Norwegian university hospital.MethodsSingle‐centre retrospective review. Medical records of all patients admitted to Stavanger University Hospital with suspected endophthalmitis between January 1999 and December 2018 were reviewed.ResultsWe identified 84 eyes of 81 patients. Postoperative endophthalmitis (PE) was seen in 64 eyes (76%), endogenous endophthalmitis in thirteen eyes (15%), trauma in four eyes (5%) and three eyes (4%) had keratitis‐associated endophthalmitis. Administration of intravitreal injections (IVI) was the most common cause (30%), followed by cataract surgery (CS) (21%). Of 40238 IVI, 23 PE cases were identified (incidence, 0.057%; 95% confidence interval [CI] 0.036–0.086%). Of 39697 CS, 12 PE cases were identified (incidence, 0.030%; 95%CI 0.016–0.053%). After introduction of intracameral cefuroxime PE incidence after CS decreased from 0.10% in 1999–2003 to 0.015% in 2004–2018 (p = 0.003). Eighty‐four per cent of organisms were Gram‐positive. Coagulase‐negative staphylococci accounted for 54% of culture‐proven cases, and 89% of post‐IVI culture‐proven cases. Thirty eyes (36%) either regained their previous vision or lost ≤1 Early Treatment Diabetic Retinopathy Study line. One third of endophthalmitis cases had a favourable visual outcome of logMAR 0.2 or better.ConclusionPE after IVI occurred in 1 in 1750 procedures, and was the most common cause of PE. The incidence of PE after CS has decreased >sixfold since 2003, to 1 in 6700 surgeries. A high proportion of low‐virulence bacterial species may have contributed to the favourable visual outcome.
Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity
Authors: Darmaun Laura , Lejeune Stephanie , Drumez Elodie , Mur Sebastien , de Langle‐Chevalier Fanny , Nève Véronique , Storme Laurent , Michaud Laurent , Gottrand Frederic , Thumerelle Caroline , Deschildre Antoine 
Published: June 2020

AbstractAimTo assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA).MethodsA cross‐sectional study in CDH children (≥7 years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise) and Pediatric Quality of Life Inventory questionnaires (PedsQoL 4.0) were collected. Data of OA children were previously published.ResultsFifty‐four CDH patients (male: 53%, median age: 11 years, IQR 9‐14) were compared to 54 OA patients (male: 61%, median age: 13 years, IQR: 11‐15). CDH children had significantly more frequent history of pneumonia (30% vs 13%), exercise limitation (54% vs 35%) and chest deformity (39% vs 11%); 46% had an obstructive pattern and 66% an abnormal cardiopulmonary exercise test. The median PedsQoL total score in children was 81 (IQR 73‐90) in CDH and 81 (IQR 72‐91) in OA (P = .8). In CDH, duration of neonatal oxygen therapy, hospitalisation for respiratory disease, exercise limitation, inhaled corticosteroids treatment, chest deformity, abnormal cardiopulmonary exercise test and lower forced expiratory volume in one second were significantly associated with lower QoL scores.ConclusionPedsQoL scores remained satisfactory in CDH children with CDH, with no difference compared to OA. Patients with respiratory morbidity and lung function impairment, who displayed lower scores, should be identified in order to optimise their management in reference centres.
Laparoscopic gastrectomy for heart failure patients with left ventricular assist devices
Authors: Ishida Tomo , Takahashi Tsuyoshi , Miyazaki Yasuhiro , Kurokawa Yukinori , Tanaka Koji , Makino Tomoki , Yamasaki Makoto , Nakajima Kiyokazu , Mori Masaki , Doki Yuichiro 
Published: June 2020

AbstractLeft ventricular assist devices (LVADs) currently play an important role in the treatment of patients with end‐stage heart failure who require a bridge to heart transplantation. As the LVAD population increases, the incidence of cancer patients with an LVAD is assumed to be increasing as well. For gastric cancer patients with an LVAD, surgery may be the only curative treatment, especially as chemotherapy is scarcely available. However, we cannot perform an upper‐middle incision in these patients because of the LVAD's location and driveline. Furthermore, to reduce the risk of driveline infection, minimally invasive surgery is desirable. Therefore, laparoscopic surgery is, where possible, suitable for achieving a secure approach to the abdominal cavity. However, laparoscopic surgery for patients with LVAD requires careful consideration not only for anesthetic management, but also for the technical procedure. We ingenuously performed laparoscopic gastrectomy for a gastric cancer patient with LVAD to preserve the device and obtain a good surgical view.
Single‐incision plus two‐port robotic surgery for sigmoid colon cancer using the Senhance robotic system
Authors: Hirano Yasumitsu , Kondo Hiroka , Miyawaki Yutaka , Sugita Hirofumi , Sakuramoto Shinichi , Yamaguchi Shigeki 
Published: June 2020

AbstractInformed by our experiences with reduced‐port surgery for colorectal cancer, we performed the first single‐incision plus two‐port robotic sigmoidectomy for cancer with the Senhance robotic system. A 70‐year‐old woman presented to our department for the treatment of sigmoid colon cancer. We performed single‐incision two‐port robotic sigmoidectomy. A wound protector was inserted through a 3.0‐cm transumbilical incision, a multiport access device was mounted on top of it, and then a camera port and a 5‐mm assistant's port were placed in the multiport access device. Two extra ports were placed on the central line of the abdomen. Lymph node dissection around the inferior mesenteric artery and mobilization of the left‐sided colon were completed without any perioperative complications. The total operative time was 204 minutes, and the console time was 113 minutes. The estimated blood loss was 75 mL. The patient was discharged on postoperative day 8 without any complications.
Effect of using Acacia mearnsii tannin extract as a feed additive on nutritional variables and productive performance in dairy cows grazing a temperate pasture
Authors: Orlandi Tiago , Pozo Claudio A. , Schiavo Jordana , Oliveira Lisandre , Kozloski Gilberto V. 
Published: June 2020

AbstractThis study was carried out to evaluate the impact of including Acacia mearnsii tannin extract (TA) as a feed additive on nutrition and productive performance of dairy cows grazing a high‐quality temperate pasture and receiving supplementation with a concentrate feedstuff. Fourteen multiparous Holstein cows were assigned to either of the following treatments: concentrate without or with 20 g TA/kg dry matter (DM). Concentrate intake accounted for 32% of the total DM intake. Tannin addition increased the herbage DM intake by 22% (p < .05). There was no effect of TA inclusion on milk yield, milk composition, milk nitrogen (N) excretion, milk and plasma urea‐N concentration, urinary excretion of total N, urea‐N, and purine derivatives. However, TA inclusion increased the N intake and retention, total N excretion in manure, fecal N to urine N ratio, and decreased the dietary N efficiency for milk production and the percentage of ingested N excreted in urine (p < .05). In conclusion, supplementing dairy cows grazing a high‐quality temperate pasture with a concentrate containing 20 g TA/kg DM showed the potential of decreasing the proportion of ingested N excreted in urine without affecting the productive performance.
Presentation, disease progression and outcomes of adrenal gland metastases
Authors: Mao Jimmy J. , Dages Kelley N. , Suresh Malavika , Bancos Irina 
Published: June 2020

AbstractObjectiveData on the presentations and outcomes of patients with adrenal gland metastases are limited. Our objectives were to characterize the prevalence of adrenal metastases subtypes and investigate how varying clinical presentations affect disease progression, development of primary adrenal insufficiency (PAI) and mortality.DesignSingle institution tertiary centre, retrospective cohort study from 1997 to 2020.Patients and MeasurementsAdult patients with adrenal metastases. Clinical, radiologic and biochemical presentations and outcomes were reviewed.ResultsOf 579 patients (62.3% men, median age 67 years [range 25‐92]) with adrenal metastases (median tumour size of 30 mm [range 5‐200]), 339 (58.5%) were discovered during cancer staging, 210 (36.3%) were found incidentally, and 29 (5.0%) based on symptoms. Tumours originated from the lung (226, 39.0%), genitourinary (GU) (160, 27.6%), gastrointestinal (GI) (79, 13.6%) and other (114, 19.7%) organ systems. Bilateral metastases were found in 140 (24.2%) patients at the time of initial diagnosis, and 249 (43.0%) had bilateral disease throughout the study course. PAI developed in 12.4% of patients with bilateral disease and was associated with larger tumour size. Median follow‐up time was 14 months (range 0‐232), and 442 (76.3%) patients died. Higher mortality was independently associated with older age, adrenal metastases originating from the lung, bilateral disease, and the absence of adrenalectomy.ConclusionsAdrenal gland metastases originated most commonly from lung, GU and GI malignancies. Bilateral adrenal metastases occurred in 43% of patients, and PAI occurred in 12.4% of those with bilateral disease, warranting further case detection strategies.
The role of endothelial nitric oxide synthase gene polymorphisms in patients with lung cancer
Authors: Koçer Canan , Benlier Necla , Balci Sibel Oğuzkan , Pehlivan Sacide , Şanli Maruf , Nacak Muradiye 
Published: June 2020

AbstractObjectivesLung cancer is a disease characterized by uncontrolled cell growth in the lung tissues. The most common causes of lung cancer include smoking, exposure to radon gas, asbestos, environmental pollutants as well as genetic factors. Nitric oxide (NO) has potential mutagenic and carcinogenic activity and may play an important role in lung cancer. Endothelial NO, synthesized from L‐arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis and tumor cell proliferation. The aim of the present study was to examine the possible relationship between eNOS gene intron 4 variable number of tandem repeat (VNTR) and exon 7‐G894T (Glu298Asp)polymorphisms and lung cancer risk.MethodsDNA was extracted from peripheral blood leukocytes of 107 lung cancer patients and 100 control subjects. Designated polymorphisms were identified by polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP).ResultsOur study showed that the frequencies of theb/bgenotype andballele of eNOS gene intron 4 VNTR polymorphism were significantly higher in lung cancer patients than in controls (P < 0.05). However, there was no significant association betweeneNOS gene G894Tpolymorphism and lung cancer risk (P > 0.05).ConclusionThese results suggest that the presence of the intron 4 VNTR*ballele andb/bgenotype may be a genetic risk factor for development of lung cancer. Further larger‐scale studies are needed to confirm these findings.
Is bronchoscopic view a reliable method in diagnosis of tracheobronchial aspergillosis in critically ill non‐neutropenic patients?
Authors: Youssif Sahar Farghly , Hassan Elham Ahmed , Moharram Ahmed Mohamed , Farhan Mohammed Ameen , Badary Dalia M. , Hasan Ali Adel Azeem 
Published: June 2020

AbstractIntroductionPulmonary aspergillosis is the main respiratory fungal infection however; its diagnosis is missed or delayed in critically ill non‐neutropenic patients. Despite the utility of fiberoptic bronchoscopy for the evaluation of tracheobronchial aspergillosis (TBA) in immunocompromised patients has been extensively studied, however its utility in critically ill non‐neutropenic patients is underestimated.ObjectivesTo assess the bronchoscopic changes suspected TBA relative to the microbiological and histopathological aspects in critically ill non‐neutropenic patients admitted to respiratory intensive care unit (RICU).MethodsWe prospectively studied 139 critically ill non‐neutropenic patients admitted to RICU and had a clinical suspicion of broncho‐pulmonary Aspergillus infection. Those patients were subjected to clinical and bronchoscopic assessment for the evaluation of suspected TBA. Microbiological culture of bronchoalveolar lavage (BAL) and histopathological examination of tracheobronchial biopsies were done.ResultsBronchoscopic changes suspected TBA were found in 48.2% of patients (67/139), where Aspergillus infection was confirmed microbiologically in 59.7% (40/67) and histopathologically in 56.7% (38/67). Of these changes, whitish plaques ± ulcers, pseudomembrane and/or sticky secretion with hyperemic mucosa were detected in 68.7%, 26.9% and 16.4% respectively. These changes were mostly seen in the main bronchi (54/67; 80.6%). The sensitivity, specificity, positive, negative predictive values and overall accuracy of these bronchoscopic changes as compared with BAL fluid results were 83.3%, 70.3%, 53.2%, 91.2% and 74.1% respectively.ConclusionsBronchoscopy could be a reliable procedure for TBA diagnosis in critically ill non‐neutropenic patients. Whitish plaques ± ulcers were the prominent bronchoscopic changes with reasonable diagnostic accuracy for prediction of TBA.
Relationship between right ventricular dilatation and blood copeptin levels in patients with acute pulmonary embolism
Authors: Usul Eren , Ozkan Seda , Höke Mehmet Hilmi , Kaya Aynur Ecevit , Ucar Fatma , Cimen Tolga 
Published: June 2020

AbstractPurposeIn this study, we aimed to investigate the importance of copeptin in the diagnosis of acute pulmonary embolism, detection of right ventricular dilatation and clinical severity and prognosis of pulmonary embolism.Materials and MethodsIn the study three groups were created; Group 1: Pulmonary embolism patients with right ventricular dilatation in echocardiography, Group 2: Pulmonary embolism patients without right ventricular dilatation in echocardiography, Group 3: Healthy people. Five mL of venous blood was collected for the measurement of serum copeptin from the patients and control group. D‐dimer and troponin were studied with routine blood samples. Complaints, symptom and physical examination findings, tomography and echocardiography results, laboratory results of patients and treatments they received were recorded for the statistical analysis.ResultsCopeptin levels of acute pulmonary embolism patients were significantly higher than healthy individuals (P < 0.001). Copeptin values of Group 1 patients were significantly higher than Group 2 patients and Group 3 patients (P < 0.001). There was a statistically significant difference the levels of copeptin, D‐dimer and troponin between patients with right ventricular dilatation and patients without right ventricular dilatation (P < 0.05). AUC value in detecting right ventricular dilatation of copeptin was found to be 0.82, while specificity was 83.3% and sensitivity was 69.6%. Copeptin, D‐dimer and troponin levels of patients with increased pulmonary artery pressure were statistically significantly higher than patients with normal pulmonary artery pressure (P < 0.05).ConclusionCopeptin can be used in the diagnosis of acute pulmonary embolism and in the detection of right ventricular dilatation in pulmonary embolism.
Over the limit? Testing non‐linear associations between alcohol outlets and young adults' alcohol consumption
Authors: Foster Sarah , Hooper Paula , Divitini Mark , Knuiman Matthew , Trapp Georgina 
Published: June 2020

AbstractIntroduction and AimsBy specifying a threshold at which the number of liquor licences has the most impact on local populations, authorities can work to restrict licence approvals and help prevent alcohol‐related harm.Design and MethodsRaine Study Generation 2 participants reported their alcohol intake at 22 years (n = 843) and liquor licences within 1600 m of participants' homes were mapped. Analyses examined associations between licences (all licences, on‐premise licences, liquor stores) and alcohol intake (g ethanol per day). Two models were fitted: (i) forced a straight‐line relationship; and (ii) allowed a curved relationship via restricted cubic splines.ResultsThe straight‐line and curved models showed significant relationships with all licences (P = 0.002 and P = 0.002 respectively) and on‐premise licences (P = 0.006 and P = 0.01 respectively), but not liquor stores (P = 0.065 and P = 0.13 respectively). The straight‐line model indicated that alcohol consumption increased, on average, by 0.15 g per day for each additional licence and 0.17 g per day for each additional on‐premise licence. The curved model indicated that consumption increased by around 0.4 g per day for each additional licence from 0 to 10, but increases were negligible for additional licences beyond 10. The curved model provided a better overall fit to the data than the straight‐line model (R2 9.52% vs. 9.18%), but the improvement in fit did not quite reach statistical significance (P = 0.08). The curvature was similar, but less pronounced for on‐premise licences (R2 9.11% vs. 8.95%; P = 0.23).Discussion and ConclusionsResults suggest a possible saturation point at which additional licences have a smaller effect on the alcohol intake of 22‐year‐olds living in metropolitan Perth.