bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome
Authors: Tran Conny H. , Vaiana Michael , Nakuci Johan , Somarowthu Ala , Goff Kevin M. , Goldstein Nitsan , Murthy Priya , Muldoon Sarah F. , Goldberg Ethan M. 
Published: February 2020

Recurrent seizures, which define epilepsy, are transient abnormalities in the electrical activity of the brain. The mechanistic basis of seizure initiation, and the contribution of defined neuronal subtypes to seizure pathophysiology, remains poorly understood. We performedin vivotwo-photon calcium imaging in neocortex during temperature-induced seizures in male and female Dravet syndrome (Scn1a+/−) mice, a neurodevelopmental disorder with prominent temperature-sensitive epilepsy. Mean activity of both putative principal cells and parvalbumin-positive interneurons (PV-INs) was higher inScn1a+/− relative to wild-type controls during quiet wakefulness at baseline and at elevated core body temperature. However, wild-type PV-INs showed a progressive synchronization in response to temperature elevation that was absent in PV-INs fromScn1a+/− mice. Hence, PV-IN activity remains intact interictally inScn1a+/− mice, yet exhibits decreased synchrony immediately before seizure onset. We suggest that impaired PV-IN synchronization may contribute to the transition to the ictal state during temperature-induced seizures in Dravet syndrome.SIGNIFICANCE STATEMENTEpilepsy is a common neurological disorder defined by recurrent, unprovoked seizures. However, basic mechanisms of seizure initiation and propagation remain poorly understood. We performedin vivotwo-photon calcium imaging in an experimental model of Dravet syndrome (Scn1a+/− mice)—a severe neurodevelopmental disorder defined by temperature-sensitive, treatment-resistant epilepsy—and record activity of putative excitatory neurons and parvalbumin-positive GABAergic neocortical interneurons (PV-INs) during naturalistic seizures induced by increased core body temperature. PV-IN activity was higher inScn1a+/− relative to wild-type controls during quiet wakefulness. However, wild-type PV-INs showed progressive synchronization in response to temperature elevation that was absent in PV-INs fromScn1a+/− mice before seizure onset. Hence, impaired PV-IN synchronization may contribute to transition to seizure in Dravet syndrome.
Central Bank Independence and Inflation: The Matters of Financial Development and Institutional Quality
Authors: Kunaedi Agung , Darwanto Darwanto 
Published: February 2020

The inverse relationship between the independence of the central bank (CBI) and inflation became a consensus that trusted throughout the world. However, there is no conclusive explanation of why and how central bank independence has succeeded in suppressing inflation. The purpose of this study is to examine the influence of financial development and institutional quality on the relationship between central bank independence and inflation. Using 20 Countries of Asia with institutional diversity, this study analyzed through a dynamic panel approach (GMM-Arellano and Bond Estimator). The result indicates that the inverse relationship between central bank independence and inflation depends on the development of the financial sector and also the institutional quality of each country. In other words, to make the central bank's independence work effectively in order to solve bias inflation, the improvement of the financial sector and also the institutional quality is needed.JEL Classification : E580, E310, E020 How to Cite:Kunaedi, A., & Darwanto. (2020). Central Bank Independence and Inflation: The Matters of Financial Development and Institutional Quality. Signifikan: Jurnal Ilmu Ekonomi, Vol. 9(1), 1-14. doi: http://dx.doi.org/10.15408/sjie.v9i1.12899.
Editorial
Authors: Gómez-Botero Maryory Astrid 
Published: February 2020

As is widely known, in recent years the impact factor of scientific journals has been the main indicator of their quality, based on the premise that a citation is a quality reference. Expressly, given the unfeasibility of another type of qualitative analysis, more easily quantifiable criteria are used. In order to contribute to this debate, Jason Priem et al. published in 2010 the Altmetrics manifesto, questioning the current framework (Impact Factor), and visualizing some available options to measure other indicators [1]. Thus, rooted in the hashtag affordance, they initiate a debate that could help improve the scope of the impact factor and incorporate the scope of new alternative metrics or Altmetrics. The term Altmetrics refers to a set of indicators that attempt to accurately describe the interaction and impact of an article within the scientific community and is proposed as an alternative to the impact factor generating a better indicator than the relationship established with the journals publishing the article [2]. Another definition of Altmetrics considers the mechanisms of quantitative evaluation, in real time, of the social and academic impact of scientific publications and researcher influence. They represent a new method of measuring the impact of scientific research, based on new indicators that attempt to quantify the presence and dissemination of scientific activity on the social networks [3]. Lin and Fenner propose a set of alternative metrics, in which they also establish a logical evolution according to the degree of engagement between users and scholarly objects, considering five parameters [4]:
Pelatihan Pembuatan Produk Hukum Desa Di Pemerintahan Desa Kecamatan Sumberpucung Kabupaten Malang
Authors: Sukriono Didik , Rapita Desinta Dwi 
Published: February 2020

Undang-Undang Nomor 6 Tahun 2014 tentang Desa mengakomodasi banyak hal yang muaranya untuk melindungi dan memberdayakan desa agar menjadi lebih kuat, maju, madiri dan demokratis. Dengan demikian, Desa diberikan kepercayaan, amanah dan tanggung jawab untuk mengelola wilayahnya. Salah satu wujud kewenangan desa untuk mengatur kepentingan masyarakatnya adalah melalui pembentukan produk hukum desa untuk mengatur penyelenggaraan pemerintahan desa, mengatur pelaksanaan pembangunan, pembinaan masyarakat, pemberdayaan masyarakat dan pelayanan umum.Hanya sayangnya belum semua desa menyusun peraturan desa, dan jika sudah membuat peraturan desa belum semua peraturan desanya sesuai dengan kaidah legalislative drafting. Hal ini terjadi hampir diseluruh desa di wilayah Kabupaten Malang, termasuk salah satunya yang berada di wilayah Kecamatan Sumberpucung. Metode palaksanaan kegiatan pengabdian adalah dengan analisis situasi, identifikasi masalah, pelaksanaan pelatihan sebagai pemecahan masalah serta refleksi dan evaluasi. Hasil pelatihan menunjukkan bahwa banyak desa yang belum mampu membuat produk hukum desa. Awalnya mereka tidak tahu konsep pembuatan produk hukum desa yang sesuai dengan legislative drafting, tapi akhirnya mereka paham dan dapat membuat produk hukum desa bagi desanya masing-masing.DOI: http://dx.doi.org/10.17977/um032v1i12018p010
PENDAMPINGAN PEMBENTUKAN STANDAR PELAYANAN PUBLIK PEMERINTAHAN DESA SEBAGAI UPAYA MEWUJUDKAN GOOD VILLAGE GOVERNANCE
Authors: Habibi Muhammad Mujtaba , Sukriono Didik , Rapita Desinta Dwi , Sudirman Sudirman 
Published: February 2020

Kegiatan pendampingan dala artikel ini bertujuan untuk membantu dalam pembentukan standar pelayanan publik pemerintahan desa di kecamatan sumberpucung kabupaten Malang. Metode pelaksanaan kegiatan ini adalah Participatory Action Research (PAR) yang dilaksanakan dengan beberapa tahap, yaitu tahap perencanaan, tahap pelaksanaan, dan tahap evaluasi. Terdapat permasalahan yang dihadapi oleh Pemerintah Desa Kecamatan Sumberpucung antara lain Belum tersusun dan terbentuknya standar pelayanan publik publik di Pemerintahan; Desa-desa di Kecamatan Sumberpucung Kabupaten Malang dan masyarakat belum memahami mekanisme penyusunan dan pembentukan standar pelayanan publik; Rendahnya kualitas penyelenggaraan pelayanan publik di Pemerintahan Desa Kecamatan Sumbepucung Kabupaten Malang. Dari permasalahan yang ada maka ditindaklanjuti dengan pelaksanaan workshop pembuatan standar pelayanan publik dan pendampingan pelaksanaan pelayanan publik di setiap desa di Kecamatan Sumberpucung Kabupaten Malang. Hasil dari pelaksanaan tersebut menjadikan Peserta workshop dapat membuat peraturan Standar Pelayanan Publik yang sesuai dengan kaidahnya dan mulai mempraktekkan di Pemerintahan Desa masing-masing.DOI: http://dx.doi.org/10.17977/um032v2i12019p019
PELATIHAN PTK BAGI GURU IPS SMP/MTS MALANG RAYA
Authors: Wiradimadja Agung , Kurniawan Bayu , Sukamto Sukamto 
Published: February 2020

Di sekolah pastinya selalu ada permasalahan dalam belajar di kelas, baik masalah kesulitan belajar ataupun sikap perserta didik yang tidak sesuai norma dan nilai sosial. Guru yang profesional adalah guru yang dapat memanajemen permasalahan tersebut dengan cara memperbaikinya. Perbaikan masalah dalam pembelajaran di kelas, dapat ditempuh oleh guru melalui penelitian tindakan kelas (PTK). Belum banyaknya guru IPS di SMP/MTs Malang Raya yang bisa melakukan PTK. Hal tersebut dikarenakan kurangnya pengetahuan guru IPS akan cara perencanaan, pelaksanaan dan penulisan laporan PTK. Maka dari itu, dilakukan pelatihan PTK bagi guru IPS SMP/MTs Malang Raya sebagai program pengabdian kepada masyarakat. Metode pelaksanaan yakni dengan cara mengunndang langsung para grur IPS Malang Raya melalui Komunitas MGMP IPS. Hasilnya, pertama kegiatan pelatihan PTK dapat terealisasikan dengan baik oleh tim. Kedua, agar guru dapat memanfaatkan laporan hasil penelitian tindakan kelas untuk digunakan sebagai kenaikan pangkat, tim pengabdian kepada masyarakat memberikan juga materi tentang cara dan teknik menulis artikel ilmiah dari laporan PTK.DOI: http://dx.doi.org/10.17977/um032v2i12019p006
Relationship between postoperative recurrence rate and eosinophil density of nasal polyp: a record based retrospective study
Authors: Assiri Kholood S. , Al-shahrani Abdullah , Alwadai Abdullah H. , Al Ahmari Mohammad S. 
Published: February 2020

<p class="abstract"><strong>Background:</strong> Nasal polyposis is one of the chronic sever airway diseases. It is known as a non-neoplastic inflammatory process of nasal mucosa that eventually leads to the outgrowth of abnormal masses inside the mucosa of nasal cavity and paranasal sinuses. Eosinophils and nasal polyps are believed to affect the surgical outcome of chronic rhinosinusitis (CRS). This study was conducted to determine relationship between postoperative recurrent nasal polyp rate and types of histopathology of nasal polyp.</p><p class="abstract"><strong>Methods:</strong> A retrospective study of 121 patients at Khamis Mushayt General Hospital (Aseer region, Saudi Arabia) from 2012 to 2017. All diagnosed and treated for nasal polyposis with different histopathological types. we collect all the recurrent cases with the same histopathological result. </p><p class="abstract"><strong>Results:</strong> The study included 121 patients with polyps whose ages ranged from 18 to 77 years old. 58% were males and 42% were females. it was noticed that 33.9% of edematous types of polyps with Eosinophilic infiltration were recurrent compared to 25% of other types among patients below the age of 30 years with no statistical significance. At patients above 30 years, the recurrence rate among eosinophilic type was significantly higher than other types (54.5% compared to 13.3%, respectively).</p><p class="abstract"><strong>Conclusions:</strong> Presence of mucosal eosinophilia is a more important factor than nasal polyps for classifying CRS in terms of the surgical outcome. Patients with mucosal eosinophilia had higher polyp recurrence rate than patients without mucosal eosinophilia, whereas patients with nasal polyps did not have higher polyp recurrence rate than patients without nasal polyps.</p>
Endonasal dacryocystorhinostomy: evaluation of the anatomical and functional results
Authors: Tadke Kanchan , Lahane Vaibhav , Sarode Akshay , . Nitish 
Published: February 2020

<p class="abstract"><strong>Background:</strong> Dacryocystorhinostomy is a novel surgical technique for NLD obstruction performed by external and endonasal approach. Both procedures have variable success rates and advantages or disadvantages. The objectives were to study functional and anatomic outcomes of endoscopic DCR and to assess degree of ostium shrinkage in postoperative period.</p><p class="abstract"><strong>Methods:</strong> Prospective study comprising 68 patients of NLD obstruction with 70 procedures performed during the period of October 2014 to October 2016. Various dimensions of bony neo-ostium were recorded intraoperatively and during 1st and 3rd month follow up. Mitomycin C was applied in 37 cases. Degree of ostium shrinkage and its correlation with surgical success was studied. Outcome of study was measured as functional and anatomical success. </p><p class="abstract"><strong>Results:</strong> 68 patients in age range of 7 to 71 years. Mean intraoperative height and width were 12.0±2.08 mm and 5.17±0.82 mm respectively and intraoperative surface area of ostium was 62.77±17.27mm<sup>2</sup>. The study showed strong positive correlation between initial and final ostium size. The final ostium irrespective of its size, if patent does not result in recurrence of symptoms and can be considered as success. In the present study, functional and anatomical success was 97.14% and failure rate was 2.86%.</p><p><strong>Conclusions:</strong> Both functional and anatomical success require creation of patent neo-ostium, although the intraoperative size of ostium is not the deciding factor for final outcome. Complete exposure of lacrimal sac, adequate mucosal preservation, good marsupialization and mucosal apposition are the some of the crucial factors responsible for stable ostium patency and hence the surgical success.</p>
The non-isothermal kinetics of hydroxyapatite formation in kaolin - natural phosphate mixtures
Authors: Chouia Fateh , Belhouchet Hocine , Sahraoui Toufik 
Published: February 2020

In this work, the activation energy of hydroxyapatite formation in different composites under non-isothermal conditions was determined using differential thermal analysis (DTA). Seven compositions were prepared and studied while varying the percentage of the kaolin from 20 to 80 wt.% at 10% increments. The DTA conducted at heating rates of 10, 20 and 30 K minâˆ’1 showed an exothermic peak in all composites in the region 700Â°Câ€“750Â°C associated with hydroxyapatite formation. The activation energies measured from non-isothermal treatments for seven compositions (20, 30, 40, 50, 60, 70 and 80 mass% of kaolin) were 194, 178, 178, 209, 162, 146 and 121 kJ molâˆ’1, respectively.

Keywords:energy, kinetics, kaolin - natural, phosphate mixtures
EXAMINING THE OUTREACH OF ISLAMIC CHARITY BASED MICROFINANCE PROGRAMS: EMPIRICAL EVIDENCE FROM INDONESIA
Authors: Yumna Aimatul , Clarke Matthew 
Published: February 2020

One of the advantages of using Islamic social funds is the increased ability of microfinance institutions to provide financial services to the poor. This study aims to (1) investigates the characteristics of the clients of the Islamic Charity Based Microfinance (ICBM) program; (2) test whether the clients ICBM program are more vulnerable than the non clients group (3) discuss the rationale of why poor excluded from the zakat based microfinance program. The study was conducted in the microfinance program at zakat institutions namely Baitul Maal Muamalat (BMMI), BAZNAS, and Baitul Maal Beringharjo (BMB). A total of 236 respondents including clients and non-clients of three case study institutions were participated in this study. The data is analyzed using binomial logit model to evaluate factors affecting clients participation in ICBM programs in Indonesia. The findings show that clients and non-clients of ICBM have a similar demographic profile and the majority ICBM clients live above the national poverty line, yet they live perilously close to the edge of the poverty line. Using logistic regression, this study found that the higher the client’s income level, the higher the probability of their being selected in the program. This findings contradict with the existing Islamic microfinance literature that claim ICBM institutions in general could demonstrate a capacity to extend their services more widely to the poorest if Islamic charity is the main source of microfinance funding. This study suggests some possible barriers to include the poor in the microfinance including institutional selection policy and self exclusion factors.
The Isochronal Performance Method of Determining the Flow Characteristics of Gas Wells
Authors: Cullender M.H. 
Published: February 2020

Published in PetroleumTransactions, AIME, Volume 204, 1955, pages 137–142.

Abstract
The performance characteristics of gas wells producing from formations which fail to stabilize within a relatively short period of time are obscured by the interrelation of the coefficient (C) and the slope "n" of the conventional back-pressure curve
(Equation 1)
Case History of Reservoir Performance of a Highly Volatile Type Oil Reservoir
Authors: Woods Rex W. 
Published: February 2020

Published in PetroleumTransactions, AIME, Volume 204, 1955, pages 156–159.

Abstract
The case history of performance of a highly volatile type oil reservoir which is now greater than 80 per ant depleted is presented. The reservoir is at a depth of approximately 8,200 ft and includes an area greater than 7,500 acres. The reservoir has been exploited by 10 wells which to date have yielded about 10,880,000 bbl of stock tank oil by pressure depletion. Reservoir pressure has declined from an original of 5,000 psi to approximately 1,450 psi. Produced gas/oil ratio has increased from 3,200 to 23,000 cu ft/ bbl with a corresponding increase in API gravity of the stock tank oil from 44° to 62°. Pressure and fluid data are given for different stages of depletion.

Introduction
In papers by Sloan, and Cook, Spencer and Bobrowski, properties of highly volatile type reservoir oil were discussed in detail and methods were presented for predicting performance of reservoirs containing this type of fluid. The purpose of this paper is to present performance history of a highly volatile type oil reservoir designated as Reservoir A which has been produced by pressure depletion and field separation without processing of gas.

Geology
The reference field which includes Reservoir A is a structural feature north of a trend of major folding along a northeast-southwest axis. In the area of development, the structure has the appearance of a dome with formation dip of three to four degrees, but structural relations between the reference field and the axis of major folding to the south have not been determined. No faulting within the field is evident. Oil and gas productive sands have been found at depths of 7,000 ft to 10,000 ft in a columnar section of Mio-Oligocene age. The sand bodies in the section are lenticular and usually continuity of sand is limited to a small area. Sand A which forms Reservoir A at a depth of 8,200 ft, however, has exceptional continuous development in the reference field.
Investigation of Various Refined Oils for Formation Fracturing
Authors: Hendrickson A.R. , Foster G.L. , Rosene R.B. 
Published: February 2020

Published in Petroleum Transactions, AIME, Volume 204, 1955, pages 285–288.

Abstract
The properties of some of the common fracturing oils, such as sand-falling rate, fluid loss and viscosity, are a function of the three major constituents of the oil. These are: asphaltic material, paraffin waxes and a base oil. The base oil can be either high or low viscosity.
Asphaltic material increases viscosity by thickening the oil, decreasing the rate of fall of sand through the oil, at temperatures up to 200° F.
When large amounts of paraffin wax are present, much of the wax is not dissolved, but is present in the form of microscopic crystals. This, of course is limited to temperature below the melting points of waxes. As a result, paraffin waxes do not function primarily as thickeners, but rather as bulking materials.
The function of wax, without asphaltic material, in a low viscosity base oil is uniquely unlike that of wax with asphalt coexistent in the oil. The resulting difference in wax crystal size governs the sand-falling rate to a large extent.
An ideal type of fracturing oil is one containing neither asphalt nor waxes. In such cases, the viscosity and resulting low sand-falling rate are apparently due to soluble resinous hydrocarbons, which are compatible with formation oils.

Introduction
Since the introduction of hydraulic fracturing as a method of stimulating production from oil and gas wells, a variety of fluids have been employed to open the fractures and carry the propping agent. Such fluids include gels, emulsions, and oils. In the latter category, the use of refined oils has increased tremendously, and it is probably safe to assume that such oils represent more than one-half of the total fluid used in fracturing.
Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy.
Authors: Kauffmann Maëlis , Bobot Mickaël , Daniel Laurent , Torrents Julia , Knefati Yannick , Moranne Olivier , Burtey Stéphane , Zandotti Christine , Jourde-Chiche Noemie 
Published: February 2020

Abstract
BACKGROUND: The seroprevalence of human Parvovirus B19 (PVB19) is 70-85 % in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We aimed to describe the cases of 4 patients with kidney injury related to PVB19 primary infection, and to evaluate the seroprevalence of PVB19 and the incidence of PVB19 primary infection in patients undergoing a native kidney biopsy.METHODS: Cases of PVB19 infection with kidney injury were reviewed from the archives of the department of Nephrology. A systematic screening of anti-PVB19 IgG and IgM antibodies and viral DNA was performed in sera from 100 consecutive patients with a kidney biopsy in 2017-2018.RESULTS: The 4 patients with PVB19 infection-associated kidney disease displayed: one lupus-like glomerulonephritis (GN) without lupus auto-antibodies, one minimal change disease with tubular necrosis, one secondary hemolytic and uremic syndrome and one membrano-proliferative GN. In the 100 patients biopsied, 67 had elevated anti-PVB19 IgG, among whom 8 had elevated IgM, without circulating viral DNA, without any particular renal pathological pattern. One additional patient showed a seroconversion at the time of kidney biopsy, which revealed a class V lupus nephritis. CONCLUSION: PVB19 primary infection can be associated with different kidney diseases. The seroprevalence of PVB19 among patients with a kidney biopsy is similar to the overall population, and primary infection is rarely documented (1%) after systematic screening. Whether PV19 is nephrotoxic, or triggers renal endothelial injury and immune activation, remains to be elucidated.