bluuebunny/crossref_metadata_2025_split huggingface dataset:
m6A modification in RNA: biogenesis, functions and roles in gliomas
Authors: Zhang Yuhao , Geng Xiuchao , Li Qiang , Xu Jianglong , Tan Yanli , Xiao Menglin , Song Jia , Liu Fulin , Fang Chuan , Wang Hong 
Published: September 2020

AbstractThe chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas.
Degenerated oocyte in the cohort adversely affects IVF outcome
Authors: Atzmon Yuval , Michaeli Mediea , Poltov Diana , Rotfarb Nechami , Lebovitz Oshrit , Aslih Nardin , Shalom-Paz Einat 
Published: September 2020

AbstractThe presence of Degenerated Oocyte (DEG) was mostly described after intracytoplasmic sperm injection (ICSI), with fewer reports on DEG at the time of ovum pick-up (OPU). This study aims to assess morphokinetics of embryos cultured in a time-lapse incubator and compare cohorts with and without DEG at OPU. In a retrospective cohort study from January 1, 2016 until September 31, 2017 a total of 399 IVF/ICSI cycles and 2980 embryos were evaluated. In 81 of 399 cycles at least one DEG oocyte was observed at the time of OPU. The remaining 318 cycles with no DEG oocyte were compared as a control group. In the DEG group, significantly more oocytes were collected per patient (12.9 ± 7.2 vs. 10.1 ± 6.1. P < 0.001). Fertilization rate, pregnancy and clinical pregnancy rates were comparable between the two groups, however, the morphokinetics and developmental scores of the embryos were significantly worse in the DEG group, (KID 3.4 ± 1.6 vs. 3.2 ± 1.6 P = 0.002 and ESHRE 1.5 ± 1.1 vs. 1.4 ± 1.0 P = 0.046). Significantly more patients achieved top-quality embryos in the NON DEG group (58.8% vs. 53.0%, P = 0.03), however, comparable delivery rate was achieved in both groups. In the DEG group, the frequency of DEG oocyte per cycle was negatively correlated with pregnancy rate. GnRH agonist protocol and the 17-20G needle used for OPU were significant predictors for the presence of DEG oocyte at OPU. In conclusions DEG oocyte may negatively affect IVF outcome, however, younger patients, and significantly more oocytes collected in the DEG group compensate for the IVF results.
Cardiorespiratory effects of project energize: a whole-of region primary school nutrition and physical activity programme in New Zealand in 2011 and 2015
Authors: Cairncross Carolyn , Obolonkin Victor , Coppinger Tara , Rush Elaine 
Published: September 2020

Abstract
Background
Since 2004, Sport Waikato has delivered Project Energize, a through-school nutrition and physical activity program to primary schools in the Waikato. As part of the program’s continued assessment and quality control, the programme was evaluated in 2011 and 2015. This paper’s aim was to compare the cardiorespiratory fitness (time to run 550 m (T550)) levels of children participating in Project Energize in 2011 and 2015.

Methods
In the 2011 evaluation of Project Energize, gender specific- T550-for-age Z scores (T550AZ) were derived from the T550 of 4832 Waikato children (2527 girls; 2305 boys; 36% Māori) aged between 6 and 12 years. In 2015, T550 was measured for 4798 (2361 girls; 2437 boys; 32% Māori) children, representative of age, gender and school socioeconomic status (SES). The T550AZ for every child in the 2015 study and 2011 evaluation were derived and differences in T550 between 2015 and 2011 by gender, SES and age were determined using independent t-tests. Multiple regression analysis predicted T550 Z score and run time, using year of measurement, gender, ethnicity, age and school SES.

Results
With and without adjustment, children in 2015 ran 550 m faster than in 2011 (adjusted Z score 0.06, time 11 s). Specifically, girls ran at a similar speed in 2015 as 2011 but boys were faster than in 2011 (Z score comparison P < 0.001, mean difference 0.18 95%CI 0.12, 0.25). Regression analysis showed time taken to run 550 m was 11 s less in 2015 compared with 2011. Boys ran it 13 s faster than girls (Z score 0.07) and for each 1 year age increase, children were 8 s slower (Z score 0.006). For each 10% decrease in SES, children were 3 s slower (Z score 0.004) and Māori children were 5 s slower than Non-Māori children (Z score 0.15).

Conclusions
The findings from this study support the continuation of the delivery of Project Energize in the Waikato region of New Zealand, as cardiorespiratory fitness scores in 2015, compared to 2011, were improved, particularly for lower SES schools and for Māori children. Ethnically diverse populations, schools with higher deprivation and girls, continue to warrant further attention to help achieve equity.
δ-β-Gabor integral operators for a space of locally integrable generalized functions
Authors: Al-Omari Shrideh Khalaf , Baleanu Dumitru , Nisar Kottakkaran Sooppy 
Published: September 2020

AbstractIn this article, we give a definition and discuss several properties of the δ-β-Gabor integral operator in a class of locally integrable Boehmians. We derive delta sequences, convolution products and establish a convolution theorem for the given δ-β-integral. By treating the delta sequences, we derive the necessary axioms to elevate the δ-β-Gabor integrable spaces of Boehmians. The said generalized δ-β-Gabor integral is, therefore, considered as a one-to-one and onto mapping continuous with respect to the usual convergence of the demonstrated spaces. In addition to certain obtained inversion formula, some consistency results are also given.
Hermite–Jensen–Mercer type inequalities for conformable integrals and related results
Authors: Butt Saad Ihsan , Nadeem Mehroz , Qaisar Shahid , Akdemir Ahmet Ocak , Abdeljawad Thabet 
Published: September 2020

AbstractIn this paper, certain Hermite–Jensen–Mercer type inequalities are proved via conformable integrals of arbitrary order. We establish some different and new fractional Hermite–Hadamard–Mercer type inequalities for a differentiable function f whose derivatives in the absolute values are convex.
Assessing knowledge, attitude, practice, and preparedness of hospital pharmacists in Lebanon towards COVID-19 pandemic: a cross-sectional study
Authors: Zeenny Rony M. , Ramia Elsy , Akiki Youssef , Hallit Souheil , Salameh Pascale 
Published: September 2020

Abstract
Background
During the COVID-19 pandemic, the Lebanese government has taken the proactive anticipatory measure to minimize the infection rates. Despite the pivotal role of the pharmacists working in hospital settings, hospital pharmacists have not been engaged in the emergency preparedness for hospitals. The primary objective of this survey is to assess the knowledge, attitude, and practice of hospital pharmacists in Lebanon towards COVID-19 pandemic and explore the level of health emergency preparedness of Lebanese hospitals in response to this outbreak.

Methods
A standardized English-based, anonymous and online questionnaire was diffused via social media platforms to all Lebanese hospital pharmacists. The questionnaire consisted of 78 questions related to sociodemographic characteristics, knowledge-based, attitude-based, practice questions, and pandemic preparedness. Descriptive statistical analysis was used to summarize data.

Results
A total of 81 questionnaires were completed; the participants were able to know > 90% of the knowledge-based questions regarding COVID-19. Most of the respondents were concerned about getting infected and their families due to their professional exposure. Similarly, around 67% were following the safety recommendations. Most of the participants agreed that they are facing shortages, rising prices, and delays in supply of masks and sanitizers. In terms of COVID-19 readiness, about 50% of hospitals have taken practical steps.

Conclusions
Our findings revealed an appropriate level of knowledge and good practice towards COVID-19, among the respondents from Lebanese hospitals. National organizations may benefit in utilizing the expertise of the hospital pharmacists to be able to minimize/avoid future waves of COVID-19 if it emerges.
Diagnostic characteristics of 11 formulae for calculating corrected flow time as measured by a wearable Doppler patch
Authors: Kenny Jon-Émile S. , Barjaktarevic Igor , Mackenzie David C. , Eibl Andrew M. , Parrotta Matthew , Long Bradley F. , Eibl Joseph K. 
Published: September 2020

AbstractBackgroundChange of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics for detecting SV change reported. Further, little is known about the inherent Ftc variability induced by the respiratory cycle.Materials and methodsUsing a wearable Doppler ultrasound patch, we studied the clinical performance of 11 Ftc equations to detect a 10% change in SV measured by non-invasive pulse contour analysis; 26 healthy volunteers performed a standardized cardiac preload modifying maneuver.ResultsOne hundred changes in cardiac preload and 3890 carotid beats were analyzed. Most of the 11 Ftc equations studied had similar diagnostic attributes. Wodeys’ and Chambers’ formulae had identical results; a 2% change in Ftc detected a 10% change in SV with a sensitivity and specificity of 96% and 93%, respectively. Similarly, a 3% change in Ftc calculated by Bazett’s formula displayed a sensitivity and specificity of 91% and 93%. FtcWodeyhad 100% concordance and anR2of 0.75 with change in SV; these values were 99%, 0.76 and 98%, 0.71 for FtcChambersand FtcBazetts, respectively. As an exploratory analysis, we studied 3335 carotid beats for the dispersion of Ftc during quiet breathing using the equations of Wodey and Bazett. The coefficient of variation of Ftc during quiet breathing for these formulae were 0.06 and 0.07, respectively.ConclusionsMost of the 11 different equations used to calculate carotid artery Ftc from a wearable Doppler ultrasound patch had similar thresholds and abilities to detect SV change in healthy volunteers. Variation in Ftc induced by the respiratory cycle is important; measuring a clinically significant change in Ftc with statistical confidence requires a large sample of beats.
Presence of Fermentable Oligo-, Di-, Monosaccharides, and Polyols (FODMAPs) in commonly eaten foods: extension of a database to indicate dietary FODMAP content and calculation of intake in the general population from food diary data
Authors: Liljebo Therese , Störsrud Stine , Andreasson Anna 
Published: September 2020

Abstract
Background
FODMAPs (Fermentable Oligo-, Di-, Monosaccharides And Polyols) are known for their health benefits but their fermentation may trigger gastrointestinal symptoms and a low-FODMAP diet is a commonly used intervention for functional gastrointestinal disorders. The use of direct measures of FODMAP is labor intensive and expensive and to facilitate the assessment of FODMAP intake in research and clinical work, a nutritional content database with good quality estimates on FODMAP values is needed. Further, the average intake of FODMAP in a general population would be a useful reference and knowledge of the most commonly eaten foods containing FODMAPs would facilitate clinical work utilizing FODMAP diet interventions.

Methods
A nutritional content database was extended with published FODMAP content data. The database was used to calculate FODMAP intake from four-day food diaries from 117 individuals from the general population in Sweden and the most common food items containing FODMAPs were identified.

Results
FODMAP content for 1060 food items was added to the database resulting in 1805 listed FODMAP values. Mean intake of total FODMAP in the diaries was 19 g (fructose: 15.2 g; fructan: 3.5 g; lactose: 14.1 g; galacto-oligosaccharides (GOS) 0.43 g and polyols 1.3 g per day). Overall the most common eaten food items containing FODMAPs were rye and wheat based foods.

Conclusion
Intake of FODMAPs as calculated using the extended database were in line with previous studies supporting its use of the database in both research and clinical interventions. The lists of the most commonly eaten FODMAP food items are provided and may be used to facilitate FODMAP diet interventions.
Farm data analysis for lifetime performance components of sows and their predictors in breeding herds
Authors: Koketsu Yuzo , Iida Ryosuke 
Published: September 2020

AbstractOur objectives in this review are 1) to define the four components of sow lifetime performance, 2) to organize the four components and other key measures in a lifetime performance tree, and 3) to compile information about sow and herd-level predictors for sow lifetime performance that can help producers or veterinarians improve their decision making. First, we defined the four components of sow lifetime performance: lifetime efficiency, sow longevity, fertility and prolificacy. We propose that lifetime efficiency should be measured as annualized piglets weaned or annualized piglets born alive which is an integrated measure for sow lifetime performance, whereas longevity should be measured as sow life days and herd-life days which are the number of days from birth to removal and the number of days from date of first-mating to removal, respectively. We also propose that fertility should be measured as lifetime non-productive days, whereas prolificacy should be measured as lifetime pigs born alive. Second, we propose two lifetime performance trees for annualized piglets weaned and annualized piglets born alive, respectively, and show inter-relationships between the four components of the lifetime performance in these trees. Third, we describe sow and herd-level predictors for high lifetime performance of sows. An example of a sow-level predictor is that gilts with lower age at first-mating are associated with higher lifetime performance in all four components. Other examples are that no re-service in parity 0 and shorter weaning-to-first-mating interval in parity 1 are associated with higher fertility, whereas more piglets born in parity 1 is associated with higher prolificacy. It appears that fertility and prolificacy are independent each other. Furthermore, sows with high prolificacy and high fertility are more likely to have high longevity and high efficiency. Also, an increased number of stillborn piglets indicates that sows have farrowing difficulty or a herd health problem. Regarding herd-level predictors, large herd size is associated with higher efficiency. Also, herd-level predictors can interact with sow level predictors for sow lifetime performance. For example, sow longevity decreases more in large herds than small-to-mid herds, whereas gilt age at first-mating increases. So, it appears that herd size alters the impact of delayed gilt age at first-mating on sow longevity. Increased knowledge of these four components of sow lifetime performance and their predictors should help producers and veterinarians maximize a sow’s potential and optimize her lifetime productivity in breeding herds.
Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study
Authors: Oyedeji Charity I. , Hall Katherine , Luciano Alison , Morey Miriam C. , Strouse John J. 
Published: September 2020

AbstractBackgroundThe life expectancy for people with sickle cell disease (SCD) has improved tremendously over the last 50 years. This population experiences hemolysis and vaso-occlusion in multiple organs that lead to complications such as cardiopulmonary disease, strokes, and avascular necrosis. These complications can limit mobility and aerobic endurance, similar to limitations that often occur in geriatric populations. These sickle-cell and age-related events lead to frequent hospitalization, which further increases the risk of functional decline. We have few tools to measure functional decline in people with SCD. The purpose of this paper is to describe a protocol to evaluate the feasibility of sickle cell disease geriatric assessment (SCD-GA).Methods/designWe will enroll 40 adults with SCD (20 age 18–49.99 years and 20 age ≥ 50 years) in a prospective cohort study to assess the feasibility of SCD-GA. The SCD-GA includes validated measures from the oncology geriatric assessment enriched with additional physical and cognitive measures. The SCD-GA will be performed at the first study visit, at 10 to 20 days after hospitalization, and at 12 months (exit visit). With input from a multidisciplinary team of sickle cell specialists, geriatricians, and experts in physical function and physical activity, we selected assessments across 7 domains: functional status (11 measures), comorbid medical conditions (1 measure), psychological state (1 measure), social support (2 measures), weight status (2 measures), cognition (3 measures), and medications (1 measure). We will measure the proportion completing the assessment with feasibility as the primary outcome. Secondary outcomes include the proportion consenting and completing all study visits, duration of the assessment, acceptability, and adverse events.DiscussionWe present the protocol and rationale for selection of the measures included in SCD-GA. We also outline the methods to determine feasibility and subsequently to optimize the SCD-GA in preparation for a larger multicenter validation study of the SCD-GA.
Sexual violence victimisation among university students in Italy: a gendered intersectional quantitative approach
Authors: Ortensi Livia Elisa , Farina Patrizia 
Published: September 2020

AbstractThere is rising attention in Italy and Europe to the occurrence, consequences, and factors related to sexual violence. The focus on women as the primary victims of sexual violence has, however, left data collection and research on young men and sexual minorities in the background. Moreover, young people’s experiences of sexual abuse in the context of their relationships with peers are hardly recognised as a policy concern. The ultimate aim of this paper is to disentangle intersectionalities between gender, migration background, sexual orientation, and sexual experience in shaping the risk of experiencing sexual violence among university students in Italy.We use data from the Sexual and Emotional LiFe of Youths (SELFY) survey carried out in Italy in 2017. Our data confirm that women and foreign-born students are at higher risk of sexual violence. Our data also support previous evidence that bisexual women are at a higher risk of sexual violence victimisation compared with peer students with other sexual orientations. Previous same-sex sexual experience is more relevant than sexual orientation in shaping the risk. The effect is gendered: the risk of sexual violence is lower for women with previous same-sex sexual experience compared with their male peers. The intersection between gender, sexual orientation, and same-sex sexual experience generate specific high-risk profiles whose needs should be targeted by support services.
Variations in growth and genetic properties of Zea mays L. germinants exposed to cold shock
Authors: Ikhajiagbe Beckley , Odenore Vona D. , Ifie Josiah E. , Umeokeke Esther O. , Loveniers Pieter-Jan , Enaruna Peace I. 
Published: September 2020

Abstract
Background
Abiotic stresses like low temperatures are contributory factors to the variations observed among species during plant germination, growth, and development. The present study evaluated the morphological and genetic responses of maize (Zea mays L.) seedling to cold shock induced by a one-time exposure to low temperature. Seeds were originally exposed to distilled water at room temperature for 48 h before they were completely submerged in buckets of ice for 0.5, 1.5, 3, 6, and 12 h, respectively, and then transferred into Petri dishes. The set up was left on the laboratory bench for an additional 5 days, and plant germination parameters were measured. DNA was extracted and this was followed by RAPD—polymerase chain reaction.

Results
Significant growth impairment upon exposure to cold shock corresponding to the length of time of exposure was shown. The length of the prominent root significantly reduced upon exposure to a cold shock from 141.8 mm to as low as 91.4 mm in those plants exposed at 1.5 h. The length of the prominent leaf also significantly reduced from 100.6 mm in the control to between 62.6 and 85.5 mm in low-temperature-exposed plants (p < 0.05), notwithstanding the time of exposure. There were significant reductions in final germination percent in the low-temperature-exposed germinants (35.8–60.5%) when compared to the control (88.5%). The RAPD marker (OPA04) revealed variations in germinated maize seeds after treatment with different duration of low temperatures. The test plantlets treated for 0, 0.5, and 1.5 h have an unrecognizable complementary sequence to the primer OPA04, whereas the primer amplified regions of the genome of test plantlets treated for 3, 6, and 12 h. Primer OPA05 also presented diversity among maize seedlings stressed for various durations of cold shock.

Conclusion
The existence of genetic variations in the present study has far-reaching effects on the development of maize exposed to varying degrees of cold stress. Though restricted to germination only, they are important because the development of plants begins at the germination stage. These changes may affect the characteristics of economic importance or perhaps impact on the physiology of the maize plant eventually.
Methods to evaluate the twin formation energy: comparative studies of the atomic simulations and in-situ TEM tensile tests
Authors: Kim Hong-Kyu , Kim Sung-Hoon , Ahn Jae-Pyoung 
Published: September 2020

AbstractDeformation twinning, one of the major deformation modes in a crystalline material, has typically been analyzed using generalized planar fault energy (GPFE) curves. Despite the significance of these curves in understanding the twin nucleation and its effect on the mechanical properties of crystals, their experimental validity is lacking. In this comparative study based on the first-principles calculation, molecular dynamics simulation, and quantitative in-situ tensile testing of Al nanowires inside a transmission electron microscopy system, we present both a theoretical and an experimental approach that enable the measurement of a part of the twin formation energy of the perfect Al crystal. The proposed experimental method is also regarded as an indirect but quantitative means for validating the GPFE theory.