bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk-adapted treatment reduced chemotherapy exposure for clinical stage 1 pediatric testicular cancer
Authors: ye yunlin , Chen Zhuang-fei , Bian Jun , Liang Hai-tao , Qin Zi-ke 
Published: August 2020

Abstract
Background: Different from adult clinical stage I (CS1) testicular cancer, surveillance was recommended for CS1 pediatric testicular cancer. For high-risk children, greater than 50% of them suffered relapse and progress during surveillance and adjuvant chemotherapy was administrated. Risk-adapted treatment might reduce chemotherapy exposure for those children. Methods: The decision model was designed and calculated using TreeAge Pro 2011 software. Clinical utilities such as relapse rates of different groups during surveillance or after chemotherapy were collected from literatures. And a survey to urologist was performed to evaluate the toxicity of the first-line and second-line chemotherapy. Using decision analysis model, chemotherapy exposure between risk-adapted treatment and surveillance were compared based on this series of clinical utilities. One-way and two-way tests were administrated to check the feasibility. Results: In base case decision analysis of CS1 pediatric testicular cancer, risk-adapted treatment preferred lower exposure of chemotherapy than surveillance (average: 0.7965 cycle verse 1.3419 cycles). The sensitivity analysis demonstrated that when relapse rate after primary chemotherapy ≤0.10 and the relapse rate of high-risk group ≥0.40, risk-adapted treatment would expose lower chemotherapy, without association of the proportion of low-risk patients, the relapse rate of low-risk group, relapse rate after salvage chemotherapy and toxicity utility of second-line chemotherapy compared to first-line chemotherapy. Conclusions: Using decision analysis, risk-adapted treatment might decrease chemotherapy exposure for these high-risk patients and precious evaluation after orchiectomy was critical to this process. Further clinical study was needed to validate this statement.
Non-destructive collection survey of the historical Classense Library. Part II: Conservation scenarios
Authors: Coppola Floriana , Brown Natalie , Amicucci Floriana , Strlic Matija , Modelli Alberto 
Published: August 2020

Abstract
The effects of environmental and conservation management scenarios on the permanence of the historical book collections housed at the Classense Library (Ravenna, Italy) were investigated. Non-destructive material surveys delivered paper pH and degree of polymerisation data that, in conjunction with the Collections Demography dose-response function, provide heritage managers with estimations of the predicted collection lifetimes in diverse environmental management scenarios. For the first time, quantitative measurements of paper properties obtained in historical library collection were used to elaborate isochrone and demographic plots, evaluated against the long-term planning horizon of 500 years. The scenarios include preventive and interventive actions aiming to preserve the fitness-for-use of collection items in terms of their ability to withstand manual handling, and consider cooling, dehumidification and deacidification, as well as combinations thereof. The results inform the conservation decision-makers about the preservation outcomes of environmental management options, to be considered for further action, once environmental, economic and social sustainability of such scenarios is considered.
The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes
Authors: Gavali Joice Thomas , Carrillo Elba Dolores , Garcia Maria Carmen , Sanchez Jorge Alberto 
Published: August 2020

Abstract
Background: Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia-reperfusion, protecting the heart from damage. In this study we tested the hypothesis that opening mKATP channels regulates expression of the major components of store-operated Ca2+ entry (SOCE) STIM1 and Orai1.Results: Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and western blot experiments showed that diazoxide increased expression of STIM1 and Orai1 at the mRNA and protein levels, respectively, in adult rat cardiomyocytes. Immunofluorescence analyses revealed that diazoxide also disrupted the striated distribution pattern of STIM1. These effects were prevented by the ROS scavenger N-acetyl cysteine (NAC), the mKATP channel antagonist 5-hydroxydecanoate (5-HD), or the protein synthesis inhibitor cycloheximide (CHX). Confocal microscopy revealed that diazoxide also led to nuclear translocation of the transcription factors c-Fos and NFkB, which was also blocked by NAC or 5-HD. Finally, the MAPK pathway inhibitor UO126 attenuated diazoxide-induced upregulation of STIM1 and Orai1 expressionConclusions: Our results suggest that opening mitochondrial potassium ATP channels with diazoxide upregulates the expression of STIM1 and Orai1 by de novo synthesis by a mechanism that involves NFkB, c-Fos, and ROS via MAPK/ERK signaling.
Molecular epidemiology of a fatal sarcoptic mange epidemic in endangered San Joaquin kit foxes (Vulpes macrotis mutica)
Authors: Rudd Jaime L. , Clifford Deana L. , Cypher Brian L. , Hull Joshua M. , Riner A. Jane , Foley Janet E. 
Published: August 2020

Abstract
Background: In 2013, sarcoptic mange, caused by Sarcoptes scabiei mites, precipitated a catastrophic decline of the formerly stable urban population of endangered San Joaquin kit foxes (Vulpes macrotis mutica) in Bakersfield, California, USA. In 2019, a smaller sarcoptic mange outbreak affected kit foxes 58 km southwest of Bakersfield in the town of Taft, California. To determine whether the Taft outbreak could have occurred as spillover from the Bakersfield outbreak and whether epidemic control efforts must involve not only kit foxes but also sympatric dogs (Canis lupus familiaris), coyotes (Canis latrans), and red foxes (Vulpes vulpes), we evaluated genotypes and gene flow among mites collected from each host species.Methods: We used 10 Sarcoptes microsatellite markers (SARM) to perform molecular typing of 445 S. scabiei mites collected from skin scrapings from twenty-two infested kit foxes, two dogs, five coyotes, and five red foxes from Bakersfield, Taft, and other nearby cities.Results: We identified 60 alleles across all SARM loci; kit fox- and red fox-derived mites were relatively monomorphic, while genetic variability was greatest in Bakersfield coyote- and dog-derived mites. AMOVA analysis documented distinct mite populations unique to hosts, with an overall FST of 0.467. The lowest FST (i.e. closest genetic relationship, FST = 0.038) was between Bakersfield and Taft kit fox-derived mites while the largest genetic difference was between Ventura coyote- and Taft kit fox-derived mites (FST = 0.843).Conclusion: These results confirm the close relationship between the Taft and Bakersfield outbreaks. Although a spillover event likely initiated the kit fox mange outbreak, mite transmission is now primarily kit fox-to-kit fox. Therefore, any large-scale population level intervention should focus on treating kit foxes within the city.
Nanocomposites-Based Targeted Oral Drug Delivery Systems with Infliximab in a Murine Colitis Model
Authors: Kim Jung Min , Kim Da Hye , Park Hyo Jeong , Ma Hyun Woo , Park I Seul , Son Mi jeong , Ro So Youn , Hong SeokMann , Han Hyo Kyung , Lim Soo Jeong , Kim Seung Won , Cheon Jae Hee 
Published: August 2020

Abstract
Background Infliximab (IFX), a TNF-α blocking chimeric monoclonal antibody, induces clinical response and mucosal healing in patients with inflammatory bowel disease (IBD). However, systemic administration of this agent causes unwanted side effects. Oral delivery of antibody therapeutics might be an effective treatment strategy for IBD compared to intravenous administration. Results All three carriers had a high encapsulation efficiency, narrow size distribution, and minimal systemic exposure. There was a higher interaction between nanocomposite carriers and monocytes compared to lymphocytes in the PBMC of IBD patients. Orally administered nanocomposite carriers targeted to inflamed colitis minimized systemic exposure. All IFX delivery formulations with nanocomposite carriers had a significantly less colitis-induced body weight loss, colon shortening and histomorphological score, compared to the DSS-treated group. AC-IFX-L and EAC-IFX-L groups showed significantly higher improvement of the disease activity index, compared to the DSS-treated group. In addition, AC-IFX-L and EAC-IFX-L alleviated pro-inflammatory cytokine expressions ( Tnfa , Il1b , and Il17 ). Conclusion We present orally administered antibody delivery systems which improved efficacy in murine colitis while reducing systemic exposure. These oral delivery systems suggest a promising therapeutic approach for treating IBD.
Characterization of a rhodanese homologue from Haemonchus contortus and its immune-modulatory effects on goat immune cells in vitro
Authors: Wang Yujian , Ehsan Muhammad , Huang Jianmei , Aimulajiang Kalibixiati , Yan RuoFeng , Song XiaoKai , Xu LiXin , Li Xiangrui 
Published: August 2020

Abstract
Background: Modulation of the host immune response by nematode parasites has been widely reported. Rhodaneses (thiosulfate: cyanide sulfurtransferases) are present in a wide range of organisms, such as archaea, bacteria, fungi, plants and animals. Previously, it was reported that a rhodanese homologue could be bound by goat peripheral blood mononuclear cells (PBMCs) in vivo.Methods: In the present study, we cloned and produced a recombinant rhodanese protein originating from Haemonchus contortus (rHCRD), a parasitic nematode of small ruminants. rHCRD was co-incubated with goat PBMCs to assess its immunomodulatory effects on proliferation, apoptosis and cytokine secretion.Results: We verified that the natural HCRD protein localized predominantly to the bowel wall and body surface of the parasite. We further demonstrated that serum produced by goats artificially infected with H. contortus successfully recognized rHCRD, which bound to goat PBMCs. rHCRD suppressed proliferation of goat PBMCs stimulated by concanavalin A but did not induce apoptosis in goat PBMCs. The production of TNF-α and IFN-γ decreased significantly, whereas secretion of IL-10 and TGF-β1 increased, in goat PBMCs after exposure to rHCRD. rHCRD also inhibited phagocytosis by goat monocytes. Moreover, rHCRD down-regulated the expression of major histocompatibility complex (MHC)-II on goat monocytes in a dose-dependent manner, but did not alter MHC-I expression.Conclusions: These results propose a possible immunomodulatory target that may help illuminate the interactions between parasites and their hosts at the molecular level and reveal innovative protein species as candidate drug and vaccine targets.
Prognostic Value of Combined Detection of Serum and Pleural Fluid Tumor Markers in Non-small Cell Lung Cancer With Malignant Pleural Effusion
Authors: Xie Li-Xu , Jiang Shi-Chang , Chen Zi , Jiang Shu-Juan , Wang Xing-Guang , Zhou Lin-Fu 
Published: August 2020

Abstract
The authors have withdrawn this preprint due to erroneous posting.
Cannabinoid Hyperemesis Syndrome in the pregnant patient: clinical case and literature review
Authors: Flament Julien , Scius Nathan , Thonon Henri 
Published: August 2020

Abstract
Background

Cannabis use is on the rise. Several cases of cannabinoid hyperemesis syndrome, secondary to chronic cannabis intoxication, have been described worldwide, but few cases have described this entity in pregnant women.

Case presentation

We describe a 29-year-old pregnant patient that had consumed cannabis and experienced uncontrolled vomiting. The use of hot baths, the rapid improvement in symptoms, and results of complementary examinations suggested a diagnosis of cannabinoid hyperemesis syndrome. The patient could return home and she continued her pregnancy and childbirth without peculiarities.

Conclusion

Cannabinoid hyperemesis syndrome should be considered in the differential diagnosis of vomiting in pregnancy. Consumption of cannabis must be systematically included in the anamnesis. However, it seems to be somewhat unacceptable socially or medically. Consumption must be stopped to manage symptoms.
Mental health status of Chinese residents during the COVID-19 epidemic
Authors: Jiang Wen , Liu Xuerong , Zhang Jingxuan , Wang Jia , Feng Zhengzhi 
Published: August 2020

Abstract
Background: To investigate the mental health status of Chinese residents during the epidemic of COVID-19 and identify the positive and negative factors affecting mediating effects of negative cognitive processing bias on mental health. Methods: Using a general questionnaire, such as the self-rating depression scale, the state anxiety inventory, and the negative cognitive processing bias questionnaire, an internet-based survey was conducted on 60199 residents in China. An ordered multiple logistic regression analysis model was used to analyze the collected data. Results: The survey showed that the incidences of mild, moderate, and severe depression were 62.65%, 11.33%, and 6.14%, respectively, and that of mild, moderate and severe anxiety were 33.21%, 41.27%, and 22.99%, respectively. The results of ordered multiple logistic regression analysis showed that factors, such as female gender, age more than 55 years elderly, high school education level, medical staff, marital conflicts, negative attention bias, rumination, and death rate positively affected the level of depression and anxiety. The good family functionality, democratic working atmosphere, and a myriad of social activities negatively affected the level of depression and anxiety.Conclusion: The Chinese residents exhibited a high prevalence of anxiety and depression during the epidemic. Thus, psychological interventions should focus on the vulnerable groups, and cognitive training should focus on reducing the negative cognitive processing bias that might be an effective way to alleviate the mental stress of the general public during the COVID-19 pandemic.
Diabetic Retinopathy Predicts Cardiovascular Mortality in Diabetes: A Meta-analysis
Authors: Xu Xiao-Hong , Sun Bo , Zhong Shan , Wei Dong-Dong , Hong Ze , DONG Aiqiang 
Published: August 2020

Abstract
Background: The prognostic significance of diabetic retinopathy (DR) for cardiovascular diseases (CVD) remained unclear. Therefore, we performed this meta-analysis to assess whether DR predicted CVD mortality in diabetic patients.Methods: We searched PubMed, Embase, Web of Science and Cochrane Library for cohort studies reporting the association of DR and CVD mortality. Then we pooled the data for analysis. Results: After screening the literature, 10 eligible studies with 11,239 diabetic subjects were finally included in quantitative synthesis. The pooled risk ratio (RR) of DR, mild DR, and severe DR for CVD mortality was 1.83 (95% confidence interval (CI): 1.42, 2.36; P < 0.001), 1.13 (95% CI: 0.81, 1.59; P = 0.46), and 2.26 (1.31, 3.91; P = 0.003), respectively, compared to those without DR. In type 2 DM, the patients with DR had a significantly higher CVD mortality (RR: 1.69; 95% CI: 1.27, 2.24; P < 0.001). Subgroup analysis also showed a significantly higher CVD mortality in DR according to various regions, study design, data source, and follow-up period (all RR > 1; all P values < 0.05). Data from 2 studies showed no significant correlation of DR and CVD mortality in diabetic patients receiving cardiovascular surgery (RR: 2.40; 95% CI: 0.63, 9.18; P = 0.200). Conclusions: DR is a risk marker of cardiovascular death, and severe DR predicts a doubled mortality of CVD in diabetes. These findings indicate the importance of early identification and management of diabetic patients with DR to reduce the risk of death.
Status of Heart Failure During COVID-19 Lockdown: A Multi-centric Study From Southern India
Authors: Meenakshisundaram Ramachandran , Senthilkumaran Subramanian , Thirumalaikolundusubramanian Ponniah , Joy Melvin , Jena Narendra Nath , Ayyasamy Shyamsundar , Chandrasekaran VP 
Published: August 2020

Abstract
Background:Severe acute respiratory distress syndrome coronavirus (SARS CoV2) infection (COVID-19) has affected many countries globally. During COVID-19 lockdown, there has been a reduction in emergency room presentations and subsequent hospital admissions for many diseases. Objective: Our aim was to find out the statusof heart failure (HF) cases treated in the hospitals of during COVID-19 lockdown period, and to compare these with those cases treated during no-lockdown period and highlight the possible reasons for variations. Methods: A retrospective observational study was carried out across the nine-private hospitals located in four different cities of Tamil Nadu state, Southern India. Data on HF and emergency room attendance were collected for lockdown period (April 2020) and no-lockdown period (February 2020 as well as April 2019 and 2018) and analysed statistically. Results: During the lockdown period, there were 30 to 33% reductions in the emergency room attendance, whereas the total HF cases were more than no-lockdown period. Among HF, the proportion of ischemic HF was decreased, but the proportion of non-ischemic HF was increased, and these were independent of gender and ejection fraction sub-category. Discussion: Our observations of reduction in ischemic HF was attributable to steep reduction in air quality index in these cities, and a rise in non-ischemic HF could be due to doctor centred practice, lack of doctor-patient communication, under-utilisation of healthcare technologies including telehealth services, and poor compliance resulting in acute decompensation.
Ketamine treatment safety and tolerability in treatment-resistant depression with somatic comorbidities: focus on dissociation and psychotic symptomatology.
Authors: Włodarczyk Adam , Cubała Wiesław J. , Węgielnik-Gałuszko Maria , Wiglusz Mariusz S. 
Published: August 2020

Abstract
Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with Major Depressive Disorder and Bipolar depression.Methods: The study population of 49 inpatients comprises of MDD and BP subjects treated with ketamine registered in the naturalistic observational protocol of the tertiary reference unit for mood disorders (NCT04226963). The study may be underpowered due to the small sample size. The observations apply to inhomogeneous TRD population in a single-site with no blinding and are limited to the acute administration. Results: The epilepsy was significantly associated with changes in BPRS over time (p=0.008). Psychotic symptomatology with BPRS scores for comorbid somatic conditions excluding epilepsy turned out to be insignificant (p = 0.198) regardless the diagnosis. Conclusions: In ketamine use, careful consideration of comorbidities and concomitant medication is needed. In ketamine administration close-clinical supervision is necessary at every visit. Psychotic symptoms must be taken into consideration in planning treatment with TRD patients with epilepsy. Somatic comorbidity may impact dissociative symptomatology. Trial Registration: Study registered: 04DEC2019, clinicaltrials.com no. NCT04226963 https://clinicaltrials.gov/ct2/show/NCT04226963
Volcanic Eruptions Caused by Extreme Weather:The Role of Super Rainfall
Authors: Uchida Nobuo 
Published: August 2020

Abstract
Volcanic eruptions are well known as sources of catastrophic damage and loss of life. In general, eruptions are understood to be caused by the movement of magma upward through the volcano, until it reaches the crater or a secondary vent where it is released explosively to the environment. In the case of steam (phreatic) eruptions, the exposure of water to the extreme heat injects significant amounts of energy into the system resulting in violent explosions and substantial destruction (Leonid et al. 1995)1 .Often, there is no warning on existing seismic monitoring networks of the impending eruption. However, we demonstrate a correlation between extreme rainfall and volcanic activity at Mt. Ontake in Japan and propose that phreatic eruptions are due to a movement of water rather than magma. This work demonstrates the importance of monitoring rainfall on volcanoes to prevent loss of human life in eruptions that may follow periods of excessive precipitation.
Patients’ knowledge of diabetes complications and self-management practices in Ghana
Authors: Bossman Irene , Dare Shadrach , Oduro Bright Anyimah , Baffour Prince Kyei , Nally Jane E. 
Published: August 2020

Abstract
BackgroundThe prevalence of diabetes is increasing and over two-thirds of these are not diagnosed, especially in low and middle-income countries (LMICs). As a consequence, diabetes complications usually exist at the time of diagnosis.PurposeTo assess the knowledge and experiences of adult patients with Diabetes on diabetes complications and self-management practices with emphasis on foot care.MethodologyTwenty patients attending Diabetes clinics were purposively sampled from two hospitals in Ghana. Face-to-face interviews were conducted to evaluate patient’s understanding of diabetes and self-management practices. The interviews were audio-taped, transcribed, and analysed to generate themes using the constant comparison method.ResultsThree-quarters of the participants in the study correctly defined diabetes as high blood glucose levels, but few knew the risk factors and complications of diabetes. Stroke and Hypertension were the most popular complications known, whiles diabetes foot complications were the least known. Almost all participants showed awareness of dietary self-management practices, but few had limited knowledge in foot care practices.ConclusionDiabetes education in LMICs should promote self-management practices, especially foot care and clear dietary guidelines. There is also opportunity to invest in specialist diabetes training for healthcare providers and increase community-based care for people living with diabetes in Ghana.