bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional Association Between Psoriasis and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
Authors: Ger Tzong-Yun , Fu Yun , Chi Ching-Chi 
Published: April 2020

AbstractThe link between psoriasis and obstructive sleep apnea (OSA) has not been confirmed. We aimed to investigate the relationship between psoriasis and OSA. We conducted a systematic review and meta-analysis of case-control, cross-sectional, and cohort studies on the association between psoriasis and OSA. We searched MEDLINE and Embase for relevant studies on May 11, 2019. The Newcastle-Ottawa Scale was used to evaluate the risk of bias of included studies. We performed random-effects model meta-analysis to calculate pooled odds ratio (ORs) with 95% confidence intervals (CIs) for case-control and cross-sectional studies as well as pooled incidence rate ratio (IRR) with 95% CIs for cohort studies in association between psoriasis and OSA. A total of 4 case-control or cross-sectional studies and 3 cohort studies with a total of 5,840,495 subjects were included. We identified a significantly increased odds for OSA in psoriasis patients (pooled OR 2.60; 95% CI 1.07–6.32), and significantly increased risk for psoriasis in OSA patients (pooled IRR 2.52; 95% CI 1.89–3.36). In conclusion, our study identified a bidirectional association between psoriasis and OSA. Sleep quality should be inquired in patients with psoriasis. Respirologist consultation or polysomnography may be indicated for those presenting with night snoring, recurrent awaking, and excessive daytime sleepiness.
MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
Authors: Horváth Martin , Horváthová Veronika , Hájek Petr , Štěchovský Cyril , Honěk Jakub , Šenolt Ladislav , Veselka Josef 
Published: April 2020

AbstractWe sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without angina pectoris in whom coronary angiogram did not reveal coronary atherosclerotic disease (no coronary atherosclerosis-NCA) and a group of patients with stable angina pectoris and at least one significant coronary artery stenosis (stable coronary artery disease-SCAD). This study design allowed us to identify miRs deregulated in the setting of acute coronary artery occlusion due to VP rupture. Based on an initial large scale miR assay screening, we selected a total of 12 miRs (three study miRs and nine controls) that were tested in the study. Two of the study miRs (miR-331 and miR-151-3p) significantly distinguished STEMI patients from the control groups, while ROC analysis confirmed their suitability as biomarkers. Importantly, this was observed in patients presenting early with STEMI, even before the markers of myocardial necrosis (cardiac troponin I, miR-208 and miR-499) were elevated, which suggests that the origin of miR-331 and miR-151-3p might be in the VP. In conclusion, the study provides two novel biomarkers observed in STEMI, which may be associated with plaque rupture.
Quantifying the use of connected digital products in clinical research
Authors: Marra Caroline , Chen Jacqueline L. , Coravos Andrea , Stern Ariel D. 
Published: April 2020

AbstractOver recent years, the adoption of connected technologies has grown dramatically, with potential for improving health care delivery, research, and patient experience. Yet, little has been documented about the prevalence and use of connected digital products (e.g., products that capture physiological and behavioral metrics) in formal clinical research. Using 18 years of data from ClinicalTrials.gov, we document substantial growth in the use of connected digital products in clinical trials (~34% CAGR) and show that these products have been used across all phases of research and by a diverse group of trial sponsors. We identify four distinct use cases for how such connected products have been integrated within clinical trial design and suggest implications for various stakeholders engaging in clinical research.
Transmembrane protein rotaxanes reveal kinetic traps in the refolding of translocated substrates
Authors: Feng Jianfei , Martin-Baniandres Pablo , Booth Michael J. , Veggiani Gianluca , Howarth Mark , Bayley Hagan , Rodriguez-Larrea David 
Published: April 2020

AbstractUnderstanding protein folding under conditions similar to those found in vivo remains challenging. Folding occurs mainly vectorially as a polypeptide emerges from the ribosome or from a membrane translocon. Protein folding during membrane translocation is particularly difficult to study. Here, we describe a single-molecule method to characterize the folded state of individual proteins after membrane translocation, by monitoring the ionic current passing through the pore. We tag both N and C termini of a model protein, thioredoxin, with biotinylated oligonucleotides. Under an electric potential, one of the oligonucleotides is pulled through a α-hemolysin nanopore driving the unfolding and translocation of the protein. We trap the protein in the nanopore as a rotaxane-like complex using streptavidin stoppers. The protein is subjected to cycles of unfolding-translocation-refolding switching the voltage polarity. We find that the refolding pathway after translocation is slower than in bulk solution due to the existence of kinetic traps.
Anti-HIV agent azidothymidine decreases Tet(X)-mediated bacterial resistance to tigecycline in Escherichia coli
Authors: Liu Yuan , Jia Yuqian , Yang Kangni , Li Ruichao , Xiao Xia , Wang Zhiqiang 
Published: April 2020

AbstractRecent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resistant pathogens through interfering intrinsic resistance mechanisms or enhancing antibiotic actions. Herein, we screened a collection of drugs to identify compounds that are able to restore tigecycline activity against resistant pathogens. Encouragingly, we discovered that anti-HIV agent azidothymidine dramatically potentiates tigecycline activity against clinically resistant bacteria. Meanwhile, addition of azidothymidine prevents the evolution of tigecycline resistance inE. coliand the naturally occurring horizontal transfer oftet(X4). Evidence demonstrated that azidothymidine specifically inhibits DNA synthesis and suppresses resistance enzyme activity. Moreover, in in vivo infection models by Tet(X4)-expressionE. coli, the combination of azidothymidine and tigecycline achieved remarkable treatment benefits including increased survival and decreased bacterial burden. These findings provide an effective regimen to treat infections caused by tigecycline-resistantEscherichia coli.
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses
Authors: Oikawa Daisuke , Sato Yusuke , Ohtake Fumiaki , Komakura Keidai , Hanada Kazuki , Sugawara Koji , Terawaki Seigo , Mizukami Yukari , Phuong Hoang T. , Iio Kiyosei , Obika Shingo , Fukushi Masaya , Irie Takashi , Tsuruta Daisuke , Sakamoto Shinji , Tanaka Keiji , Saeki Yasushi , Fukai Shuya , Tokunaga Fuminori 
Published: April 2020

AbstractThe NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identified small-molecule chemical inhibitors of LUBAC, HOIPIN-1 and HOIPIN-8. Here we show that HOIPINs down-regulate not only the proinflammatory cytokine-induced canonical NF-κB pathway, but also various pathogen-associated molecular pattern-induced antiviral pathways. Structural analyses indicated that HOIPINs inhibit the RING-HECT-hybrid reaction in HOIP by modifying the active Cys885, and residues in the C-terminal LDD domain, such as Arg935 and Asp936, facilitate the binding of HOIPINs to LUBAC. HOIPINs effectively induce cell death in activated B cell-like diffuse large B cell lymphoma cells, and alleviate imiquimod-induced psoriasis in model mice. These results reveal the molecular and cellular bases of LUBAC inhibition by HOIPINs, and demonstrate their potential therapeutic uses.
Atomically dispersed palladium catalyses Suzuki–Miyaura reactions under phosphine-free conditions
Authors: Ding Guodong , Hao Leiduan , Xu Haiping , Wang Liguang , Chen Jian , Li Tao , Tu Xinman , Zhang Qiang 
Published: April 2020

AbstractSingle-atom catalysts have emerged as a new frontier in catalysis science. However, their applications are still limited to small molecule activations in the gas phase, the classic organic transformations catalyzed by single-atom catalysts are still rare. Here, we report the use of a single-atom Pd catalyst for the classic Suzuki–Miyaura carbon–carbon coupling reaction under phosphine-free and open-air conditions at room temperature. The single-atom Pd catalyst is prepared through anchoring Pd on bimetal oxides (Pd-ZnO-ZrO2). The significant synergetic effect of ZnO and ZrO2is observed. The catalyst exhibits high activity and tolerance of a wide scope of substrates. Characterization demonstrates that Pd single atoms are coordinated with two oxygen atoms in Pd-ZnO-ZrO2 catalyst. The catalyst can be fabricated on a multi-gram scale using a simple in situ co-precipitation method, which endows this catalytic system with great potential in practical applications.
Non-bonded force field model with advanced restrained electrostatic potential charges (RESP2)
Authors: Schauperl Michael , Nerenberg Paul S. , Jang Hyesu , Wang Lee-Ping , Bayly Christopher I. , Mobley David L. , Gilson Michael K. 
Published: April 2020

AbstractThe restrained electrostatic potential (RESP) approach is a highly regarded and widely used method of assigning partial charges to molecules for simulations. RESP uses a quantum-mechanical method that yields fortuitous overpolarization and thereby accounts only approximately for self-polarization of molecules in the condensed phase. Here we present RESP2, a next generation of this approach, where the polarity of the charges is tuned by a parameter, δ, which scales the contributions from gas- and aqueous-phase calculations. When the complete non-bonded force field model, including Lennard-Jones parameters, is optimized to liquid properties, improved accuracy is achieved, even with this reduced set of five Lennard-Jones types. We argue that RESP2 withδ ≈ 0.6 (60% aqueous, 40% gas-phase charges) is an accurate and robust method of generating partial charges, and that a small set of Lennard-Jones types is a good starting point for a systematic re-optimization of this important non-bonded term.
Absence of superconductivity in bulk Nd1−xSrxNiO2
Authors: Li Qing , He Chengping , Si Jin , Zhu Xiyu , Zhang Yue , Wen Hai-Hu 
Published: April 2020

AbstractSuperconductivity at 9–15 K was recently discovered in Nd0.8Sr0.2NiO2 films. Since the Ni1+ ionic state in NdNiO2 may have the same 3d9 outer-shell electronic orbital as in cuprate superconductors, it is interesting to know whether superconductivity has a similar mechanism in these two systems. Here we synthesize bulk samples of Nd1−xSrxNiO2 (x = 0, 0.2, 0.4) with inhomogeneous Sr distribution and Ni deficiency. Resistivity measurements show insulating behavior without the presence of superconductivity, different to the previously reported films. Although applying pressure up to about 50.2 GPa significantly suppresses the insulating behavior, superconductivity remains absent. The magnetization behavior exhibits a Curie–Weiss law with a paramagnetic moment of about 2 μB/f.u. Since the lattice constants derived from our diffraction data are very close to the previously reported superconducting Nd0.8Sr0.2NiO2 films, we suggest that superconductivity in that system may have arisen from interface or stress-related effects, or nickel deficiency in our bulk samples that might prevent the emergence of superconductivity.
Self-gravitating barotropic equilibrium configurations of rotating bodies with smoothed particle hydrodynamics
Authors: García-Senz D. , Cabezón R. M. , Blanco-Iglesias J. M. , Lorén-Aguilar P. 
Published: April 2020

Context. Self-gravitational rotating bodies do not have spherically symmetric geometries. The study of physical events appearing in fast-spinning compact stars and accretion disks, for example those due to localized thermonuclear ignitions in white dwarfs or to the role played by hydrodynamic instabilities in stars and disks, often requires 3D simulations. When the numerical simulations are carried out with the smoothed particle hydrodynamics (SPH) technique a critical point arises as to how to build a stable initial model with rotation because there is no well-established method for that purpose.
Aims. We want to provide a portable, easy-to-implement methodology for SPH simulations to procedurally generate physically sound, stable initial conditions for rotating bodies.
Methods. We explain and validate an easy and versatile novel relaxation method to obtain 3D equilibrium configurations of rotating bodies with SPH. As detailed below, this method is able to relax barotropic, P(ρ), structures either in rigid or differential rotation. The relaxation procedure strongly relies on the excellent conservation of angular momentum that characterizes the SPH technique.
Results. We applied our proposal to obtain stable rotating structures of single white dwarfs, compact binaries harboring two white dwarfs, high-density stars approached as polytropes and accretion disks either in rigid or differential rotation.
Conclusions. We present a novel relaxation method to build 3D rotating structures of barotropic bodies using the SPH technique. The method has been successfully applied to a variety of zero-temperature white dwarfs and polytropic self-gravitating structures. Our SPH results have been validated by comparing the main features (energies, central densities, and the polar-to-equatorial radius ratio) to those obtained with independent grid-based methods, for example, the self-consistent field method, showing that both methods agree within a few percent.
Hydrogen non-equilibrium ionisation effects in coronal mass ejections
Authors: Pagano P. , Bemporad A. , Mackay D. H. 
Published: April 2020

Context. A new generation of coronagraphs used to study solar wind and coronal mass ejections (CMEs) are being developed and launched. These coronagraphs will heavily rely on multi-channel observations where visible light (VL) and UV-EUV (ultraviolet-extreme ultraviolet) observations provide new plasma diagnostics. One of these instruments, Metis on board ESA-Solar Orbiter, will simultaneously observe VL and the UV Lyman-α line. The number of neutral hydrogen atoms (a small fraction of coronal protons) is a key parameter for deriving plasma properties, such as the temperature from the observed Lyman-α line intensity. However, these measurements are significantly affected if non-equilibrium ionisation effects occur, which can be relevant during CMEs.
Aims. The aim of this work is to determine if non-equilibrium ionisation effects are relevant in CMEs and, in particular, when and in which regions of the CME plasma ionisation equilibrium can be assumed for data analysis.
Methods. We used a magneto-hydrodynamic (MHD) simulation of a magnetic flux rope ejection to generate a CME. From this, we then reconstructed the ionisation state of hydrogen atoms in the CME by evaluating both the advection of neutral and ionised hydrogen atoms and the ionisation and recombination rates in the MHD simulation.
Results. We find that the equilibrium ionisation assumption mostly holds in the core of the CME, which is represented by a magnetic flux rope. In contrast, non-equilibrium ionisation effects are significant at the CME front, where we find about 100 times more neutral hydrogen atoms than prescribed by ionisation equilibrium conditions. We find this to be the case even if this neutral hydrogen excess might be difficult to identify due to projection effects.
Conclusions. This work provides key information for the development of a new generation of diagnostic techniques that aim to combine visible light and Lyman-α line emissions. The results show that non-equilibrium ionisation effects need to be considered when we analyse CME fronts. Incorrectly assuming equilibrium ionisation in these regions would lead to a systematic underestimate of plasma temperatures.
Unilateral versus bilateral endoscopic stenting in patients with unresectable malignant hilar obstruction: a systematic review and meta-analysis
Authors: Aghaie Meybodi Mohamad , Shakoor Delaram , Nanavati Julie , Ichkhanian Yervant , Vosoughi Kia , Brewer Gutierrez Olaya I. , Kalloo Anthony N. , Singh Vikesh , Kumbhari Vivek , Ngamruengphong Saowanee , Khashab Mouen A. 
Published: April 2020

Abstract
Background and study aims Endoscopic stent placement is used for palliative management of unresectable malignant hilar obstruction, which could be achieved by either unilateral or bilateral stent insertion.
Materials and methods A literature search was performed to identify studies that reported outcomes of metallic biliary stent placement in patients with malignant hilar obstruction. Weighted pooled rates (WPR) along with 95 % confidence intervals (95 %CI) were calculated to determine and compare outcomes including technical and functional success, early and late adverse events, post procedure cholangitis, and stent occlusion between two groups.
Results A total of 21 studies with 1292 patients were included. WPR of technical success was significantly higher in the unilateral group (97 %, 95 %CI: 93 –98 %) vs. bilateral group (89 %, 95 %CI: 84 –92 %) (P = 0.0.003). WPR for functional success in the unilateral and bilateral groups were 96 % (95 %CI: 91 –98 %) and 94 % (95 %CI: 91 –97 %), respectively (P = 0.48). The rate of early and late complications was comparable between the two groups.
Conclusion In patients with unresectable malignant hilar obstruction, unilateral and bilateral metallic stenting techniques are comparable in terms of efficacy and safety.
Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI
Authors: Kataoka Shinichi , Kudo Shin-ei , Misawa Masashi , Nakamura Hiroki , Takeda Kenichi , Toyoshima Naoya , Mori Yuichi , Ogata Noriyuki , Kudo Toyoki , Hisayuki Tomokazu , Hayashi Takemasa , Wakamura Kunihiko , Baba Toshiyuki , Ishida Fumio 
Published: April 2020

Abstract
Background and study aims Real-time diagnosis of colorectal polyps is needed to prevent unnecessary resection of benign polyps. The vessels in hyperplastic polyps sometimes mimic the characteristic meshed capillary network of neoplastic lesions on non-magnified narrow-band imaging (NBI). Endocytoscopy in conjunction with NBI (EC-NBI) enables more detailed vessel observation. The current study evaluated whether EC-NBI can accurately diagnose small colorectal lesions with visible vessels on non-magnified NBI.
Patients and methods This retrospective study was conducted from January to December 2016. During colonoscopy, lesion images were obtained using NBI and EC-NBI. On EC-NBI, lesions were classified as having “clear,” “unclear,” or “invisible” blood vessel margins. All specimens were resected and pathologically examined, and the association between vessel margin findings and pathological diagnosis was assessed. The lesion surface to vessel depth was measured in clear, unclear, and invisible lesions.
Results Among 114 adenomas, 108 were clear, while six were unclear. Among 36 hyperplastic polyps, eight were clear, while 28 were unclear. A micro-network (MN) pattern was seen in 106 of 114 adenomas, and four of 36 hyperplastic polyps. The sensitivity, specificity, correct diagnostic rate, and positive and negative predictive values of clear blood vessel margins or a MN pattern as an adenoma index were 98.2 %, 69.4 %, 91.3 %, 91.1 %, and 92.6 %, respectively. EC-NBI correctly diagnosed 69.4 % (25/36) of hyperplastic polyps. The lesion surface–blood vessel distance was greater in unclear versus clear lesions (P < 0.001), and invisible versus unclear lesions (P < 0.001).
Conclusions EC-NBI may effectively differentiate hyperplastic polyps with visible vessels from adenomas. Blood vessel depth affects visibility.
Bimodal ERCP, a new way of seeing things
Authors: Reuterwall Marcus , Waldthaler Alexander , Lubbe Jeanne , Kadesjö Nils , Pozzi Mucelli Raffaella , Del Chiaro Marco , Lohr Matthias , Arnelo Urban 
Published: April 2020

Abstract
Background and study aims Conventional endoscopic retrograde cholangiopancreatography (ERCP) is hampered by two-dimensional visualization, post-procedural adverse events (AEs), and exposure to ionizing radiation. Bimodal ERCP might mitigate these challenges, but no reports of its use are available to date. The aim of this study was to explore the feasibility of bimodal ERCP, while investigating its potential clinical yield.
Patients and methods This was a retrospective observational study of patients that underwent bimodal ERCP in a single tertiary academic referral center. Thirteen patients undergoing conventional ERCP had a previously T2-weighted isotropic 3 D TSE MRCP sequence aligned and fused with the two-dimensional image generated from the fluoroscopy c-arm unit in real time.
Results Over a 2-month period, 13 patients with a mean age of 54 underwent bimodal ERCP for bile duct stricture (61.5 %), complex cholelithiasis (7.7 %) and ductal leakage (30.1 %). Bimodal ERCP was feasible in all 13 cases, and image quality was assessed as “good” in 11 patients (84.6 %). Bimodal ERCP aided in visualizing the lesion of interest (76.9 %), assisted in understanding the 3 D anatomy of the biliopancreatic ductal system (61.5 %), and aided in finding a favorable position for the c-arm (38.4 %) for subsequent therapeutic intervention.
Conclusions This first report on bimodal ERCP proves its feasibility and suggests that it may assist in increasing both the diagnostic and therapeutic yield of ERCP, while at the same time decreasing AEs during and after ERCP. Its main application might lie in treatment of complex intrahepatic disease.