bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report: Type II Abernethy malformation complicated with congenital polydactyly and enlargement of all cardiac chambers.
Authors: Zhu Cheng , Wang Min , Hao Qian 
Published: December 2019

Abstract
Background: Abernethy malformation is a kind of congenital malformation of portal vein system caused by abnormal portacaval anastomosis. It can be in combination with other congenital malformations. The major therapy of Abernethy malformation is surgery. There has been a limited number of patients since the first patient reported, leading to a limited view towards this kind of disease until now.Results: In August 2018 we treated a patient diagnosed with typeII Abernethy malformation complicated with both congenital polydactyly and enlargement of all cardiac chambers, which is extremely rare and can be a supplementary to the existing cases. Besides, the low white blood cell and platelet, the arrested megakaryocytic maturation and the positive platelet autoantibody in serum may result in misdiagnosis as immune thrombocytopenia, so we analyze the differential points between these two diseases. We treated this patient with silybin orally and advised him to make follow-up visits because of his mild liver function disorder, normal cardiac function and no other malformations or complications complicated. At the latest follow-up, we knew the condition of the patient was generally satisfactory, whether in terms of laboratory test results or his daily life experience.Conclusions: Because of some changes of spleen in form and function secondary to Abernethy malformation, in some cases, this disease has similarities with a part of blood diseases, which we should take into consideration for differential diagnosis, especially when other congenital malformations are found in combination at the same time. This case also suggests that simply conservative treatment with regular follow-up visits can be suitable for certain patients.
The Eagle Jugular Syndrome
Authors: Zamboni Paolo , Scerrati Alba , Menegatti Erica , Galeotti Roberto , Lapparelli Marcello , Traina Luca , Tessari Mirko , Ciorba Andrea , De Bonis Pasquale , Pelucchi Stefano 
Published: December 2019

Abstract
Background The elongation of the styloid process is historically associated with two variants of the Eagle syndrome. The classic one, mainly characterized by pain and dysphagia, and the carotid variant characterized by pain and sometimes by cerebral ischemia. We observed a further variant characterized by a styloid elongation coursing adjacent to the transverse process of C1, causing significant compression of the internal jugular vein. Methods We revised all the cases of Eagle syndrome, including the jugular variant, admitted in our Hospital in the last six years. We compared symptomatology, associated comorbidities and imaging. Data were statistically analyzed. Results Overall 23 patients were admitted to the Hospital for symptomatic elongation of the styloid process, 11 male and 12 females. The jugular variant of the Eagle syndrome is clinically delineated by significant differences, as compared to the classic variant and carotid variants. Headache was the more prominent symptom (p<.009) as well as a documented peri-mesencephalic hemorrhage was the more significant comorbidity (p<.0003). The group classic-carotid variant was characterized by ipsilateral pain respect to the jugular variant (p<.0003). CT angiography with venous phase extended to the neck veins and imaging reconstruction is highly recommended as imaging technique, complemented by color-Doppler ultrasound. Conclusions The elongation of the styloid process may have different paths which creates compression on the surrounding anatomical structures. There may be a possible association of jugular impingement by an elongated styloid process with symptoms.
Chelating modified cellulose bearing pendant heterocyclic moiety for effective removal of heavy metals
Authors: Saravanan R. , Mahalakshmi R. , Karthikeyan M. S. , Ravikumar L. 
Published: December 2019

Abstract
Cellulose bearing pendant Schiff base with heterocyclic chelating groups (CMC-Bz) was synthesized, which were fully characterized using various instrumental techniques such as solid state carbon-13 nuclear magnetic resonance (13C-NMR), Fourier transform infrared (FTIR), scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDX) spectra. The adsorption of toxic metals onto cellulosic material was tested in a batch mode operation. The adsorption functional factors such as pH, adsorbent dose, metal ion concentration, equilibrium time and temperature were experimentally optimized for the maximum removal of Cu(II) and Pb(II) ions. Adsorption isotherms were evaluated with Langmuir, Freundlich, Temkin and Redlich–Peterson isotherms. Kinetic parameters and equilibrium adsorption capacities were investigated for pseudo-first-order, pseudo-second-order and intra-particle diffusion models. Thermodynamic parameters and reusability were also evaluated.
Simple improvement of digested sludge quality: is postaeration the key?
Authors: Vojtiskova M. , Satkova B. , Bindzar J. , Jenicek P. 
Published: December 2019

Abstract
Postaeration, where digested sludge is introduced into aerobic conditions, is a technology that could improve the quality of sludge and sludge liquor in many ways. Although it is a fairly simple process, only few data about the effect of postaeration have been published. In this study, batch experiments have been performed first, indicating that postaeration affects the total ammonia nitrogen (TAN) and sludge dewaterability. In the removal of TAN, both stripping and biological oxidation can play an important role depending on specific condition. Then the postaeration was investigated in a semicontinuous batch reactor. In addition, the effect of postaeration on the concentration of selected micropollutants such as pharmaceuticals, EOX and AOX was studied. The hydraulic retention time (HRT) of 8, 6, 4 and 2 days and different aeration intensities were tested. The TAN removal efficiency achieved was about 40–60%, sludge dewaterability expressed by sludge cake total solids (TS) concentration after dewatering improved relatively by 5–30%. In addition, TS degradation is also taking place and therefore the reduction of the amount of final sludge to be disposed could be even higher. The biggest changes in observed parameters were recorded at the longest HRT.
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease
Authors: Zhang Xiaojun , Yin Lin , Jia Xiaofang , Zhang Yujiao , Liu Tiefu , Zhang Lijun 
Published: December 2019

Background:
Moyamoya Disease (MMD) is a rare cerebrovascular disease with a high rate
of disability and mortality. Immune reactions have been implicated in the pathogenesis of MMD, however,
the underlying mechanism is still unclear.

Objective:
To identify proteins related to MMD specially involved in the immunogenesis, we performed
a proteomic study.

Methods:
In this work, dural tissues or plasma from 98 patients with MMD, 17 disease controls without
MMD, and 12 healthy donors were included. Proteomic profiles of dural tissues from 4 MMD and
4 disease controls were analyzed by an isobaric tag for relative and absolute quantitation (iTRAQ)-
based proteomics. The immune-related proteins were explored by bioinformatics and the key MMDrelated
proteins were verified by western blot, multiple reaction monitoring methods, enzyme-linked
immunosorbent assay, and tissue microarray.

Results:
1,120 proteins were identified, and 82 MMD-related proteins were found with more than 1.5
fold difference compared with those in the control samples. Gene Ontology analysis showed that 29
proteins were immune-related. In particular, Haptoglobin (HP) was up-regulated in dural tissue and
plasma of MMD samples compared to the controls, and its up-regulation was found to be sex- and
MMD Suzuki grade dependent. Through Receiver Operating Characteristic (ROC) analysis, HP can
well discriminate MMD and healthy donors with the Area Under the Curve (AUC) of 0.953.

Conclusion:
We identified the biggest protein database of the dura mater. 29 out of 82 differentially
expressed proteins in MMD are involved in the immune process. Of which, HP was up-regulated in
dural tissue and plasma of MMD, with sex- and MMD Suzuki grade-dependence. HP might be a potential
biomarker of MMD.
Label-Free Mass Spectrometry-Based Plasma Proteomics Identified LY6D, DSC3, CDSN, SERPINB12, and SLURP1 as Novel Protein Biomarkers For Pulmonary Tuberculosis
Authors: Zhang Lu , Wang Hualin , Li Na , Hu Peng , Zhu Zhaoqin , Wang Wei , Song Yanzheng , Wen Zilu , Yu Xiaoli , Zhang Shulin 
Published: December 2019

Aim:
We aimed to identify new plasma biomarkers for the diagnosis of Pulmonary Tuberculosis
(PTB).

Background:
Tuberculosis is an ancient infectious disease that remains one of the major global health problems.
Until now, effective, convenient, and affordable methods for diagnosis of PTB were still lacking.

Objective:
This study focused on constructing a label-free LC-MS/MS-based comparative proteomics
between six tuberculosis patients and six healthy controls to identify Differentially Expressed Proteins
(DEPs) in plasma.

Methods:
To reduce the influences of high-abundant proteins, albumin and globulin were removed from
plasma samples using affinity gels. Then DEPs from the plasma samples were identified using a label-free
Quadrupole-Orbitrap LC-MS/MS system. The results were analyzed by the protein database search algorithm
SEQUEST-HT to identify mass spectra to peptides. The predictive abilities of combinations of host
markers were investigated by General Discriminant Analysis (GDA), with Leave-One-Out Cross-
Validation (LOOCV).

Results:
A total of 572 proteins were identified and 549 proteins were quantified. The threshold for
DEPs was set as adjusted p-value < 0.05 and fold change ≥1.5 or ≤0.6667, 32 DEPs were found. ClusterVis,
TBtools, and STRING were used to find new potential biomarkers of PTB. Six proteins, LY6D,
DSC3, CDSN, FABP5, SERPINB12, and SLURP1, which performed well in the LOOCV method validation,
were termed as potential biomarkers. The percentage of cross-validated grouped cases correctly
classified and original grouped cases correctly classified is greater than or equal to 91.7%.

Conclusion:
We successfully identified five candidate biomarkers for immunodiagnosis of PTB in
plasma, LY6D, DSC3, CDSN, SERPINB12, and SLURP1. Our work supported this group of proteins
as potential biomarkers for PTB, and be worthy of further validation.
Revision of the Regioselectivity of the Beirut Reaction of Monosubstituted Benzofuroxans with Benzoylacetonitrile. 6-Substituted quinoxaline-2-carbonitrile 1,4- dioxides: Structural Characterization and Estimation of Anticancer Activity and Hypoxia Selectivity
Authors: Buravchenko Galina I. , Scherbakov Alexander M. , Korlukov Alexander А. , Dorovatovskii Pavel V. , Shchekotikhin Andrey E. 
Published: December 2019

Background:
Quinoxaline 1,4-dioxides have a broad range of biological activity that causes a
growing interest in their derivatives for drug discovery. Recent studies demonstrated that quinoxaline 1,4-
dioxides have a promising anticancer activity and good hypoxia-selectivity.

Objective:
The preparation, isolation, structure characterization, and screening for anticancer activity of the
first representatives of 6-substituted quinoxaline-2-carbonitrile 1,4-dioxides have been described.

Material and Method:
A series of 7- and 6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides was
synthesized by the Beirut reaction. The cytotoxicity was assessed by MTT test (72 h incubation) in normoxia
(21% O2) and hypoxia (1% O2) conditions.

Results:
We found that during the Beirut reaction between a benzofuroxan bearing an electron withdrawing
group and benzoylacetonitrile in the presence of triethylamine, in addition to well-known 7-substituted
quinoxaline-2-carbonitrile 1,4-dioxides 7-11a, the 6-isomers 7-11b are formed. Moreover, the yield of the 6-
isomers increased with the increase in the electron-withdrawing character of the substituent. For benzofuroxans
with CO2Me and CF3 groups, 6-substituted quinoxaline-2-carbonitrile 1,4-dioxides 10-11b were the major
products. Despite similarities in physicochemical and spectroscopic properties, the obtained isomers exhibit
considerable differences in their anticancer activity and hypoxia selectivity.

Conclusion:
Substituents and their electronic effects play a key role in the formation of 7- and 6-substituted
quinoxaline-2-carbonitrile 1,4-dioxides in the Beirut reaction and in the cytotoxicity properties of the obtained
isomers.
Synthesis of New 4-Chloro-6-Methylpyrimidin-2-yl-Aminophosphonates as Potential DU145 and A549 Cancer Cell Inhibitors
Authors: Reddy Gajjala Raghavendra , Reddy Chinta Raveendra , Reddy Gopireddy Venkata Subba , Rao Pasupuleti Visweswara , Swaminathan Meenakshisundaram , Krishna Balam Satheeh , Reddy Cirandur Suresh 
Published: December 2019

:
A series of new α-aminophosphonates containing potential anticancer active 4-chloro-6-
methylpyrimidin-2-amino pharmacophore were synthesized.

Background:
α-Aminophosphonates are of growing interest to the researchers due to their biological
activities. Besides aminophosphoryl functionality, which is responsible for the vital activity, incorporation
of a captivating pharmacophore on it will definitely enrich its activity.

Objective:
Erstwhile many of the reported α-aminophosphonates impregnated with bioactive heterocycles
like quinazoline, chromene, pyrazole, furan and thiophene were used as anticancer drugs, and
we are intended to enhance the anticancer potentiality of α-aminophosphonates by substituting a new
4-chloro-6-methylpyrimidin-2-yl group into its structure, specifically on nitrogen atom.

Methods:
Title compounds were synthesized by Kabachnik-Fields reaction by using sulfated Titania,
a solid acid catalyst that is encompassed with high density of Lewis acidic reaction sites. The series
of synthesized compounds were screened for in vitro anti-cancer activity and their ADMET, QSAR
and drug properties studied.

Results:
Structures of all the title compounds synthesized in high yields were confirmed by spectral
& elemental analyses. Their anti-cancer screening studies on various cell lines and evaluation of
other properties revealed their potentiality towards the inhibition of growth of DU145 & A549 cell
lines.

Conclusion:
The substitution of 4-chloro-6-methylpyrimidin-2-amino moiety on to the amino functionality
of the α-aminophosphonates is a critical task invariably due to the substitutions that are
located on α-carbon. As such, this substitution had increased the scope for growth inhibition of
DU145 and A549 cancer cells.
Pengaruh Penambahan Ekstrak Sarang Semut (Myrmecodia sp) Terhadap Bobot Akhir, Persentase Lemak Abdominal dan Hati Ayam Broiler Fase Finisher
Authors: Lisnanti Ertika Fitri , Qowim Nizarul , Fitriyah Nur 
Published: December 2019

Penelitian ini mempunyai tujuan untuk mengetahui pengaruh penambahan ekstrak sarang sarang semut (Myrmecodia sp) terhadap bobot akhir, persentase lemak abdominal dan hati ayam broiler fase finisher. Penelitian ini dilaksanakan di laboratorium Peternakan Fakultas Pertanian Universitas Islam Kadiri (UNISKA) dan Laboratorium Kimia Universitas Muhammadiyah Malang (UMM). Metode dalam penelitian ini adalah penelitian eksperimental.menggunakanÂ rancangan acak lengkap (RAL) dengan 4 perlakuan dan masingmasing perlakuan terdiri dari 5 ulangan, dan setiap petak terdiri dari 4 ekor ayam, total keseluruhan bahan percobaan 80 ekor ayam. Data penelitian dianalisis secara statistik menggunakan analisa ragam dengan uji F. Hasil analisis statistik dari penambahan ekstrak sarang semut (Myrmecodia sp) dengan dosis 5 mg/kg bb, 10 mg/kg bb, dan 15 mg/kg bb tidak memberikan pengaruh yang nyata (P>0,05) terhadap bobot akhir, persentase lemak abdominal dan hati ayam broiler. Rataan bobot akhir berkisar antara 1495,95-1518,55 (g), dan berat lemak abdominal ayam broiler berkisar antara 12.51 â€“ 14.99 gram atau 0.82% -1.00% dari berat badan. Sedangkan berat hati yang dihasilkan berkisar antara 38,15 â€“ 38,90 gram atau 2,51 â€“ 2,60 % dari berat badan, dan hasil ini menunjukkan bahwa bobot akhir,Â persentase lemak abdominal dan hati ayam broiler masih taraf normal. Disarankan untuk dilakukan penelitian lebih lanjut dan lama penggunaan ekstrak sarang semut (Myrmecodia sp) pada perlakuan.
Análisis de la presencia digital de los candidatos presidenciales de 2012 en Facebook
Authors: Espino Sánchez Germán , Martínez Rivera Tania Esmeralda 
Published: December 2019

<p>En este artículo se presenta un estudio de caso sobre el uso de Facebook en las campañas de los principales candidatos a la Presidencia de México en 2012. Se realizó un análisis de contenido de las publicaciones en Facebook de los candidatos y un análisis automatizado de las interacciones a partir de los botones sociales (“Me gusta”, “Compartir” y “Comentar”) de esta plataforma. Las campañas usaron la red Facebook con fines propagandísticos, no para dialogar y colaborar con los usuarios de Internet; fueron campañas de videopolítica más que de cultura o participación y convergencia</p>
A alteridade construída na ruptura e na transgressão
Authors: Alfeld Elisabete 
Published: December 2019

A proposta do estudo é evidenciar na construção do enredo do filme A forma da água(Del Toro, 2017) a interface fabulação/alteridade. Para isso, organizamos o texto em dois momentos: no primeiro, centramos na criação da fábula e na linguagem audiovisual; no segundo, abordamos a alteridade. O corpus teórico prioriza Blanchot (2010; 2011), Bachelard (1997), Agamben (2009), Deleuze (1997) e Lévinas (1989; 1997). Os aspectos destacados na análise referem-se à: representação do imaginário, metaforização da água; alteridade.
A escrita (do) impossível em A hora da Estrela
Authors: Rosenbaum Yudith 
Published: December 2019

Esse artigo propõe-se a discutir os embates narrativos entre o narrador Rodrigo S.M e a personagem Macabéa, no romance A hora da estrela, de Clarice Lispector, à luz de uma fundante impossibilidade que rondaria a obra: como dar forma a um ser impossível de ser apreendido pelas palavras? O acesso à Macabéa se mostra opaco e problemático, do mesmo modo que o próprio narrador se desconhece no processo de desvendar este outro esquivo. A partir dessa premissa, pretende-se observar o jogo em que se movem narrador, personagem, escritora e leitor. A "delicada e vaga existência de Macabéa", nas palavras do narrador, acaba por desafiar uma escrita dividida entre o imperativo da expressão verbal e a carência da linguagem. O que resta desse conflito entre o objeto provocativo da escritura e a dificuldade em dizê-lo é, paradoxalmente, um excesso de indagações, hesitações e peripécias narrativas. A presente leitura convoca noções psicanalíticas para compreender algumas faces deste vasto campo de sentidos.
A transgressão do discurso hegemônico da imprensa feminina nas colunas de Tereza Quadros, máscara de Clarice Lispector
Authors: Sandroni Tânia 
Published: December 2019

Em 1952, Clarice Lispector produziu, sob a máscara de Tereza Quadros, a página “Entre mulheres” no jornal Comício, dirigido por Rubem Braga, Joel Silveira e Rafael Correa de Oliveira. A coluna trazia à leitora, ao lado de receitas e orientações domésticas (comuns na imprensa feminina), textos de outros autores (muitos deles citados no livro O segundo sexo, de Simone de Beauvoir, ainda inédito no Brasil) e crônicas com temas e figuras clariceanos. Dessa forma, a página de Tereza Quadros não se constituía como um espaço modelador do estereótipo feminino, pois subvertia o discurso hegemônico da imprensa destinada a esse público apresentando questionamentos sobre o papel e o comportamento das mulheres.
Pemuda Sebagai Fasilitator Pendamping Desa
Authors: - Syamsuddin 
Published: December 2019

Pendampingan Desa adalah kegiatan untuk melakukan tindakan pemberdayaan masyarakat melalui asistensi, pengorganisasian, pengarahan dan fasilitasi Desa. Setiap desa memiliki keragaman potensi berbeda. Potensi Desa mampu di aktualisasikan sesuai dengan perancanaan dan tata kelola desa yang mapan demi keberlanjutan pembangunan desa (sustainable development). Keberlanjutan ditandai dengan adanya Generasi (pemuda) yang lahir dari realitas sosial dan sistem pengetahuan adat istiadat yang memiliki modal sosial (social capital) untuk berinteraksi dan berpartisipatif dalam self governing community sebagai fasilitator pendamping desa. Dalam makalah ini, penulis menelaah pemuda sebagai fasilitator pendamping desa agar seluruh elemen terakait mampu menerjemahkan potensi pemuda sebagai empowerment dan bertujuan sebagai perwujudan pemuda dalam berpartisipasi untuk desa, bangsa dan negara.
Faktor-faktor yang Mempengaruhi Ketidakberhasilan Program Keluarga Berencana di Desa Siaro Kecamatan Siborongborong
Authors: Susanti Sani , Hutasoit Reka 
Published: December 2019

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi ketidakberhasilan program Keluarga Berencana di Desa Siaro Kecamatan Siborongborong. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Sampel yang diambil dari penelitian ini sebanyak 60 KK/PUS yang bertempat tinggal di Desa Siaro. Dalam penelitian ini, peneliti menggunakan pengumpulan data dengan menggunakan metode Questions (angket). Teknik analisis data menggunakan Uji Kecenderungan. Hasil penelitian yang diperoleh bahwa faktor-faktor yang mempengaruhi ketidakberhasilan program keluarga berencana dapat dilihat dari dua faktor yaitu faktor internal dan faktor eksternal. faktor internal yaitu: tentang pengetahuan akseptor kategori kurang dengan skor 50%, dari segi jumlah anak kategori tinggi dengan perolehan skor 41,6%, ditinjau dari segi kesehatan kategori cukup dengan skor sebesar 33,3%, dan dari segi perolehan informasi dengan kategori kurang skor 31,6%. Dan dilihat dari uji kecenderungan pada subvariabel faktor Eksternal yaitu: tentang dukungan suami dengan kategori cukup dengan perolehan skor 43,3%, dari segi dukungan tenaga dengan kategori cukup dengan perolehan skor 50%, dan dari segi sosial budaya dengan kategori cukup dengan perolehan skor 46,6%.
Ecology and distribution patterns of Chara connivens (Charophyta, Characeae) on the Canary Islands – the first record from Fuerteventura
Authors: Rybak Andrzej S. , Woyda-Ploszczyca Andrzej M. 
Published: December 2019

Abstract
The paper presents the first record of a Chara connivens (Characeae) stand from Fuerteventura (Canary Islands, Spain). The species was previously recorded only on Tenerife and Lanzarote, mostly in marine and artificial habitats. Physicochemical parameters of water and morphological features of the thalli and plant community were analyzed. General habitat requirements of C. connivens populations located in Europe, North Africa, and South-West Asia were reviewed. The newly described stand was located in a natural rock crevice that was part of a riverbed in El Barranco de las Peñitas (Penitas Canyon). This habitat was unshaded and filled with brackish water. C. connivens co-occurred with Cladophora glomerata and Ruppia maritima. Our report on the presence of C. connivens in the Spanish territory of the Atlantic Ocean is the first in almost 40 years. The distribution of C. connivens and its plant associations on the Canary Archipelago are poorly explored, which is why this topic requires further research.