bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in hepatitis C virus seroprevalence and associated risk factors among men who have sex with men in Montréal: results from three cross-sectional studies (2005, 2009, 2018)
Authors: Lanièce Delaunay Charlotte , Cox Joseph , Klein Marina , Lambert Gilles , Grace Daniel , Lachowsky Nathan John , Maheu-Giroux Mathieu 
Published: July 2020

ObjectivesTo eliminate the hepatitis C virus (HCV) by 2030, Canada must adopt a microelimination approach targeting priority populations, including gay, bisexual and other men who have sex with men (MSM). Accurately describing HCV prevalence and risk factors locally is essential to design appropriate prevention and treatment interventions. We aimed to estimate temporal trends in HCV seroprevalence between 2005 and 2018 among Montréal MSM, and to identify socioeconomic, behavioural and biological factors associated with HCV exposure among this population.MethodsWe used data from three cross-sectional surveys conducted among Montréal MSM in 2005 (n=1795), 2009 (n=1258) and 2018 (n=1086). To ensure comparability of seroprevalence estimates across time, we standardised the 2005 and 2009 time-location samples to the 2018 respondent-driven sample. Time trends overall and stratified by HIV status, history of injection drug use (IDU) and age were examined. Modified Poisson regression analyses with generalised estimating equations were used to identify factors associated with HCV seropositivity pooling all surveys.ResultsStandardised HCV seroprevalence among all MSM remained stable from 7% (95% CI 3% to 10%) in 2005, to 8% (95% CI 1% to 9%) in 2009 and 8% (95% CI 4% to 11%) in 2018. This apparent stability hides diverging temporal trends in seroprevalence between age groups, with a decrease among MSM <30 years old and an increase among MSM aged ≥45 years old. Lifetime IDU was the strongest predictor of HCV seropositivity, and no association was found between HCV seroprevalence and sexual risk factors studied (condomless anal sex with men of serodiscordant/unknown HIV status, number of sexual partners, group sex).ConclusionsHCV seroprevalence remained stable among Montréal MSM between 2005 and 2018. Unlike other settings where HCV infection was strongly associated with sexual risk factors among MSM, IDU was the pre-eminent risk factor for HCV seropositivity. Understanding the intersection of IDU contexts, practices and populations is essential to prevent HCV transmission among MSM.
Local sales restrictions significantly reduce the availability of menthol tobacco: findings from four Minnesota cities
Authors: D'Silva Joanne , Moze Joanne , Kingsbury John H. , Lien Rebecca K , Matter Christine M , Brock Betsy , Akom Antwi 
Published: July 2020

BackgroundIn 2017 and 2018, Minneapolis, St. Paul, Duluth and Falcon Heights, Minnesota were among the first US cities to restrict the sale of menthol tobacco to adult-only stores. The study examined changes in the availability and marketing of these products following policy implementation.MethodsRetail store audits were conducted approximately 2 months pre-policy and post-policy implementation. Tobacco retail stores (n=299) were sampled from tobacco licensing lists in Minneapolis, St. Paul, Duluth and Falcon Heights, as well as six comparison cities without menthol policies. The presence of menthol tobacco was assessed, along with the number of interior and exterior tobacco ads and promotions at each store.ResultsThe majority of policy intervention stores (grocery, convenience stores and pharmacies) were compliant (Minneapolis, 84.4%; Duluth, 97.5%; and St. Paul and Falcon Heights, 100.0%) and did not sell menthol tobacco. In contrast, menthol tobacco was available in all comparison city stores, and most (96.0%) exempted tobacco shops and liquor stores post-policy implementation. Two Minneapolis convenience stores added interior tobacco shops, allowing them to continue selling menthol tobacco. Significant decreases in menthol tobacco marketing post-policy were observed in the stores’ interior in Minneapolis, St. Paul and Duluth (p<0.001) and on the stores’ exterior in Duluth (p=0.023).ConclusionsFindings demonstrate high rates of compliance, indicating that sales restrictions can significantly reduce the availability of menthol tobacco. However, challenges to policy adherence underscore the need for continued monitoring and enforcement action.
THE CHALLENGES OF STRATEGIC INNOVATION: ACHIEVING OPERATIONAL EFFECTIVENESS IN DEVELOPING COUNTRIES
Authors: TEGETHOFF THOMAS , SANTA RICARDO , SCHLUEP ISABELLE , FERNANDO MORANTE DIEGO , CRUZ MARTHA LUCIA 
Published: July 2020

Organisations are spending substantial resources on implementing product and process innovations. It is, therefore, important to evaluate if the implementation of those innovations substantially improves the effectiveness of business operations, meets the organisation’s expectations, and gains a sustainable competitive advantage. Quantitative data from 250 questionnaires were analysed using structural equation modelling. Respondents were selected from several industries in Colombia. Initial findings suggest that strategies have an indirect impact on operational effectiveness through the success of the organisational learning process. However, the organisations investigated lack the appropriate application of linkages and process innovation to achieve operational effectiveness and, therefore, sustainable competitiveness. The paper offers useful insights for organisations when implementing innovation initiatives. It also provides information for Colombian Government institutions on developing mechanisms, economic policy strategies, and business support services for enhancing the economic and commercial viability of Colombian companies in the manufacturing and service sectors. The studied organisations need to redefine the role of linkages and process innovation to complement organisational learning, as all the three dimensions together are required to foster operational effectiveness.
Impairment of Flow-Sensitive Inwardly Rectifying K
+
Channels via Disruption of Glycocalyx Mediates Obesity-Induced Endothelial Dysfunction
Authors: Fancher Ibra S. , Le Master Elizabeth , Ahn Sang Joon , Adamos Crystal , Lee James C. , Berdyshev Evgeny , Dull Randal O. , Phillips Shane A. , Levitan Irena 
Published: July 2020

Objective:

To determine if endothelial dysfunction in a mouse model of diet-induced obesity and in obese humans is mediated by the suppression of endothelial Kir (inwardly rectifying K
+
) channels.

Approach and Results:
Endothelial dysfunction, observed as reduced dilations to flow, occurred after feeding mice a high-fat, Western diet for 8 weeks. The functional downregulation of endothelial Kir2.1 using dominant-negative Kir2.1 construct resulted in substantial reductions in the response to flow in mesenteric arteries of lean mice, whereas no effect was observed in arteries of obese mice. Overexpressing wild-type–Kir2.1 in endothelium of arteries from obese mice resulted in full recovery of the flow response. Exposing freshly isolated endothelial cells to fluid shear during patch-clamp electrophysiology revealed that the flow-sensitivity of Kir was virtually abolished in cells from obese mice. Atomic force microscopy revealed that the endothelial glycocalyx was stiffer and the thickness of the glycocalyx layer reduced in arteries from obese mice. We also identified that the length of the glycocalyx is critical to the flow-activation of Kir. Overexpressing Kir2.1 in endothelium of arteries from obese mice restored flow- and heparanase-sensitivity, indicating an important role for heparan sulfates in the flow-activation of Kir. Furthermore, the Kir2.1-dependent component of flow-induced vasodilation was lost in the endothelium of resistance arteries of obese humans obtained from biopsies collected during bariatric surgery.

Conclusions:
We conclude that obesity-induced impairment of flow-induced vasodilation is attributed to the loss of flow-sensitivity of endothelial Kir channels and propose that the latter is mediated by the biophysical alterations of the glycocalyx.
Radical, Sceptical and Liberal Enlightenment
Authors: Alexander James 
Published: July 2020

Abstract
We still ask the question ‘What is Enlightenment?’ Every generation seems to offer new and contradictory answers to the question. In the last thirty or so years, the most interesting characterisations of Enlightenment have been by historians. They have told us that there is one Enlightenment, that there are two Enlightenments, that there are many Enlightenments. This has thrown up a second question, ‘How Many Enlightenments?’ In the spirit of collaboration and criticism, I answer both questions by arguing in this article that there are in fact three Enlightenments: Radical, Sceptical and Liberal. These are abstracted from the rival theories of Enlightenment found in the writings of the historians Jonathan Israel, John Robertson and J.G.A. Pocock. Each form of Enlightenment is political; each involves an attitude to history; each takes a view of religion. They are arranged in a sequence of increasing sensitivity to history, as it is this which makes it possible to relate them to each other and indeed propose a composite definition of Enlightenment. The argument should be of interest to anyone concerned with ‘the Enlightenment’ as a historical phenomenon or with ‘Enlightenment’ as a philosophical abstraction.
Development of New Method to Reposition Orthodontic Brackets Without Debonding by Using an Ultrasonic Device: An In Vitro Study
Authors: Sato Toshihito , Wakabayashi Michiru 
Published: July 2020

Objective: The purpose of this study was to develop a new method to change a bracket position without debonding the metal bracket that was bonded with a polymethyl methacrylate (PMMA) orthodontic adhesive resin by using an ultrasonic device. Materials and Methods: An originally designed scaler tip was developed for a piezoelectric ultrasonic scaler. The adhesive turned to melting state by thermal heat that was generated by ultrasonic frictional heat. When the adhesive was in melting state, the bracket was rotated approximately 20° and held in this position until the adhesive hardened again by air cooling. Shear bond strengths were measured on each sample in the control and the repositioning groups. To evaluate the thermal effects of the increased temperature on the enamel surface and pulpal cavity, extracted human lower premolars were monitored during the repositioning time. Results: The time required for the repositioning procedures was approximately 7 s. The temperature of the enamel surface increased by 53°C and the pulpal wall increased by 0.5°C during the repositioning procedures. The bonding strength showed no significant difference between the control and repositioning groups. Conclusion: This method for bracket repositioning without debonding using an ultrasonic device proved to be a new method for bracket repositioning.
Response Variations to Survey Items About Firearms in the 2004 and 2017 Behavioral Risk Factor Surveillance System
Authors: Blosnich John R. , Karras Elizabeth , Bossarte Robert M. 
Published: July 2020

Purpose: The aim of this investigation was to document the prevalence and correlates of refusing to answer a US federal health survey item about firearms in the household. Design: The cross-sectional analysis was conducted with 2004 and 2017 Behavioral Risk Factor Surveillance System (BRFSS) survey data from Texas, Oregon, Idaho, California, Kansas, and Utah states whose surveys included items about firearms in the household. Participants: Probability-based samples of adults over the age of 18 (n = 34 488 in 2017 BRFSS; n = 33 136 in 2004 BRFSS). Measures: Dichotomized measure of whether respondents answered versus refused to answer “Are any firearms now kept in or around your home?” Analysis: Weighted multiple logistic regression was used to assess how sociodemographic and health-related characteristics were associated with item refusal. Results: Approximately 1.8% (95% CI: 1.6-2.1) of respondents in 2004 and 3.9% (95% CI: 3.4-4.5) of respondents in 2017 sample refused the firearms item ( P < .01). Men were more likely than women (2004: adjusted odds ratio [aOR] = 1.81, 95% CI: 1.24-2.62; 2017: aOR = 1.60, 95% CI = 1.17-2.18) and Latino/a respondents were less likely than white respondents (2004: aOR = 0.24, 95% CI: 0.10-0.60; 2017: aOR = 0.21, 95% CI: 0.13-0.34) to refuse the firearms question. In 2004, refusal was more likely among older than younger respondents, but in 2017, age was not associated with refusal. Conclusions: Refusal to firearm-related survey items along sociodemographic characteristics warrants further research. Community-informed strategies (eg, focus groups, cognitive testing, in-depth interviews) could improve the context and wording of firearm-related items to maximize response to these items in public health surveys.
The role of peripheral perfusion index in differential diagnosis of cardiac and pulmonary-origin dyspnea in emergency service
Authors: Karaman Kıvanç , Sağlam Gürmen Ekim 
Published: July 2020

Introduction:Pulmonary and cardiac disorders are diagnosed in most patients presenting to the emergency department with dyspnea. Discrimination of pulmonary and cardiac pathologies from each other and early intervention have vital importance. Various methods have been used for assessment of peripheral perfusion, and the peripheral perfusion index) has gained popularity in recent years. This study aimed to investigate the contribution of peripheral perfusion index to the evaluation process in patients presenting with the complaint of dyspnea and diagnosed with either a pulmonary or cardiac pathology.Materials and Methods:We retrospectively reviewed the charts of patients who presented to emergency department with dyspnea between 1 July 2018 and 1 July 2019. Patients in whom the cause of dsypnea was determined to be a cardiac or pulmonary pathology were included in the study. The age, gender, peripheral perfusion index value at admission, the diagnosis, and the hospitalization status were recorded.Results:One hundred and ninety patients consisting of 106 (55.8%) males and 84 (44.2%) females were included in our study. While a pulmonary pathology was determined in 141 (74.2%) patients and a cardiac pathology in 49 (25.8%) patients, 72 (37.9%) patients were decided to be hospitalized. No difference was determined between patients with pulmonary and cardiac pathologies regarding peripheral perfusion index. When the patients were compared regarding hospitalization status and discharge from the emergency department, no significant difference was found to be present between the groups.Conclusion:Since peripheral perfusion index is a noninvasive, easy-to-perform, rapid, and reproducible test, it has been promising as a prognostic and diagnostic parameter. However, it has been realized that PPI was unsuccessful in the evaluation of patients with dyspnea, in the differential diagnosis of cardiac and pulmonary pathologies and prediction of hospitalization status in the emergency department.
Congenital Heart Diseases Associated With Cleft Lip and Palate and Its Impact on Surgical Treatment Planning of Patients With Cleft Lip and Palate—A Cross-Sectional Study
Authors: Rao Gautam , Desai Anil , Kumar Niranjan 
Published: July 2020

Objectives: The aim of this study is to know the prevalence, type of congenital heart diseases (CHDs), and its association with cleft lip and/or palate and to know the impact of CHDs on surgical treatment planning of cleft lip and palate from a craniofacial hospital specializing in orofacial clefts, head and neck cancer, and trauma management. Design: A total of 1381 patients with nonsyndromic cleft lip and palate were included in the study. This is a hospital-based retro–prospective case record analysis. The data were collected from clinical records of the patients which included clinical, chest radiographic and 2D echocardiographic findings. Total incidence of CHDs and its impact on treatment planning was evaluated using κ statistics and χ2 test. Results: There were 32 (2.32%) cleft lip and palate patients with CHDs. In 2 patients, cleft surgery was delayed by 6 to 9 months to allow the defect to decrease in size. Subacute bacterial endocarditis prophylaxis was administered in 7 patients before cleft surgery. Cardiac surgery was advised prior to cleft surgery in 3 patients. Sixteen patients with CHDs were not taken for cleft surgery considering the potential risk to the patient’s life as they had multiple cardiac anomalies. There were no intraoperative and postoperative complications in these patients. Conclusion: The results emphasize the association between clefting and CHD. The collected data suggest that there should be careful examination of children with cleft lip and palate for signs of heart disease. This could significantly reduce the morbidity/mortality of cleft lip and palate surgery making it more predictable and safer.
A case of undiagnosed X-linked retinoschisis presenting as unilateral macular demarcation line
Authors: Cozzupoli Grazia M , Amoroso Francesca , Bacquet Jean-Louis , Miere Alexandra , Mouallem-Beziere Alexandra , Souied Eric 
Published: July 2020

Purpose: We intend to describe an uncommon presentation of X-linked juvenile retinoschisis (XLRS) in a 17-year-old boy showing a macular demarcation line in the right eye and an inferior peripheral bullous retinoschisis in both right and left eye, at his first ophthalmologic examination. Methods: The patient underwent a complete ophthalmologic examination including best-corrected visual acuity assessment, anterior segment and dilated fundus examination, ultra-wide-field retinography, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, electroretinography, visual field test, and genetic molecular testing. Results: We report a rare case of genetically confirmed XLRS, presenting as a unilateral mildly-pigmented macular demarcation line (advanced sequel of unilateral spontaneous retinal reattachment of a previous retinal detachment or bullous retinoschisis) without foveoschisis in the fellow eye. Conclusion: XLRS is the most frequent cause of macular retinoschisis. The hallmark of XLRS is the evidence of a foveoschisis presenting with a characteristic spoke-wheel aspect in patients younger than 30 years of age. It is important to recognize uncommon presentations of XLRS so that the correct diagnosis is made, in order to provide the patients with appropriate genetic counseling and therapeutic care.
Mitigation of traumatic blepharoptosis with “central levator tuck”: A novel approach in upper eyelid repair
Authors: Mehta Aditi , Thakur Umang , Saini Manu , Adiga Sushant , Grewal Sartaj Singh , Kashyap Himanshu , Singh Simar Rajan , Singh Manpreet , Pujari Amar 
Published: July 2020

Purpose: Complex upper eyelid lacerations can present to the emergency department after a myriad of trauma. The goal of the surgical repair is anatomical and functional recovery along with symmetrical cosmesis. Despite meticulous surgery, post traumatic blepharoptosis may develop. We describe an additional step during upper eyelid laceration repair to help mitigate the development of traumatic blepharoptosis. Methods: Patients with traumatic eyelid laceration without head injury, globe injury or associated orbital fractures, who were planned for a primary upper eyelid repair were included. Intraoperatively, wound margins and tissues were identified to establish anatomical continuity. After the LPS muscle was reinserted onto the tarsus, a single, central suture LPS plication – the “ central levator tuck” was performed. This helped in improving the muscle action as well as strengthening its reattachment onto tarsus. Results: Four cases underwent laceration repair with this modified technique. The nature of eyelid injury, surgical technique, and the outcome at 6 months is described. Three patients had a successful outcome, whereas one patient developed early scarring which reduced with scar therapy over time. Conclusion: We describe a simple and effective “central levator tuck” technique for traumatic eyelid laceration repair with optimal functional and cosmetic outcome while reducing the development of blepharoptosis in four patients.
The experimental study of tissue integration into porous titanium implants
Authors: Tikhilov Rashid , Shubnyakov Igor , Denisov Alexey , Konev Vladimir , Gofman Iosif , Starchik Dmitry , Mikhailova Polina , Bilyk Stanislav 
Published: July 2020

Introduction: Due to a lack of uniform shapes and sizes of bone defects in hip and knee joint pathology, their fixing could benefit from using individually manufactured 3D-printed highly porous titanium implants. The objective of this study was to evaluate the extent of bone and muscle tissue integration into porous titanium implants manufactured using additive technology. Materials and methods: Porous and non-porous titanium plates were implanted into the latissimus dorsi muscle and tibia of 9 rabbits. On days 1, 60 and 90 animals were examined with x-rays. On day 60 histological tests were carried out. On day 90 the tensile strength at the implant-tissue interface was tested. Results: Histological analysis of muscle samples with porous titanium implants showed integration of connective tissue and blood vessels into the pores. Bone defect analysis demonstrated bone ingrowth into the pores of titanium with a minimal amount of fibrous tissue. The tensile strength of the muscular tissue attachment to the porous titanium was 28 (22–30) N which was higher than that of the control group 8.5 (5–11) N. Bone tissue attachment strength was 148 (140–152) N in the experimental group versus 118 (84–122) N in the control group. Conclusions: Using additive technology in manufacturing 3D-printed highly porous titanium implants improves bone and muscle integration compared with the non-porous material of the control group. This could be a promising approach to bone defect repair in revision and reconstruction surgery.
Relationship between cam morphology, hip symptoms, and hip osteoarthritis: the Musculoskeletal pain in Ullersaker STudy (MUST) cohort
Authors: Kemp Joanne L , Østerås Nina , Mathiessen Alexander , Nordsletten Lars , Agricola Rintje , Waarsing Jan H , Heerey Joshua J , Risberg May Arna 
Published: July 2020

Background: The primary aim of this study was to determine the prevalence of cam morphology in a cohort of people aged 40–55 years. Secondary aims were to: (1) determine differences in participant characteristics, physical impairments, radiographic and ultrasound appearances of people with and without cam morphology; and (2) explore associations between cam morphology and radiographic measures of hip osteoarthritis (OA). Methods: 107 people (68% women; 49 ± 4 years) from the Musculoskeletal pain in Ullensaker (MUST) Study underwent the clinical and imaging examinations. Examinations included questionnaires, hip range, functional task performance, pelvic radiographs and ultrasound. Alpha angle and radiographic hip OA (Kellgren Lawrence (KL) and minimal joint space (MJS)) were determined. Results: The prevalence of cam morphology was 42% and was bilateral in 47%. People with cam morphology were 6 times more likely to have a KL score ⩾2 (adjusted odds ratio [95% confidence intervals, p-value]) 6.386 [1.582–37.646, p = 0.012]) and 4 times more likely to have MJS <2.0 mm (adjusted odds ratio 4.032 [1.031–12.639, p = 0.045]). The prevalence of radiographic OA features ranged from 4–13% in people with cam morphology, and 0–3% in those without. Those with cam morphology also demonstrated reduced hip flexion and rotation range ( p = 0.018–0.036) compared with those without. There was no association between ultrasonic features and patient reported outcomes, and cam morphology. Conclusions: In a cohort aged 40–55 years, the prevalence of cam morphology was high (42%), with a significant relationship between cam morphology and radiographic measures of hip OA. Further longitudinal studies should explore the relationship between cam morphology and hip OA in younger people.