bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant radiation therapy alone is associated with improved overall survival compared to hormonal therapy alone in older women with estrogen receptor positive early stage breast cancer
Authors: Jhawar Sachin R. , Alpert Naomi , Taioli Emanuela , Sayan Mutlay , Bazan Jose , Park Ko Un , Stover Daniel , Cherian Mathew , White Julia , Haffty Bruce , Ohri Nisha 
Published: September 2020

AbstractBackgroundBreast conserving surgery (BCS) and adjuvant hormonal therapy (HT) without radiation therapy (RT) is an acceptable approach for older women with early stage, estrogen receptor (ER) positive breast cancer. Toxicity and compliance remain issues with HT. Adjuvant RT alone may have better compliance, but its efficacy in the absence of HT is unclear. We aim to assess patterns of adjuvant therapy and survival outcomes among older women with early stage, ER positive (ER+) breast cancer.MethodsThe National Cancer Data Base (NCDB) was used to identify 130,194 women age ≥65 years with invasive ER+, node negative breast cancer diagnosed between 2004 and 2015. All patients underwent BCS. Kaplan‐Meier survival curves were used to examine overall survival (OS). The association between adjuvant therapy and OS was assessed in multivariable Cox proportional hazards regression models.ResultsUnadjusted 5/10‐year OS rates were 90.0%/64.3% for HT and RT, 84.2%/54.9% for RT alone, 78.7%/44.5% for HT alone, and 71.6%/38.0% for no treatment; p<0.001 for all. Compared to HT alone, the 10‐year multivariable hazard ratio (HR) for death for RT alone was 0.86 (95% CI 0.82‐0.91). In propensity‐matched patients who received RT alone or HT alone (n=21,326), RT alone had significantly better survival at 5 (HRadj: 0.84) and 10 (HRadj: 0.87) years.ConclusionsOlder women with early stage ER+ breast cancer who undergo BCS and receive both HT and RT have the best survival, while RT as single‐modality therapy had higher rates of OS at 5 and 10 years compared to HT alone.
Autonomic emotional responses to food: Private label brands versus National Brands
Authors: Rita Paulo , Guerreiro João , Omarji Muhamad 
Published: September 2020

AbstractPrivate label brands (PLB) have been increasing both perceived quality and consumer acceptance in the last decades, which has compelled national brands (NBs) to invest in maintaining consumer confidence and preference. Recent economic crisis led consumers to become more price sensitive and more worried about cutting on daily needs, such as food consumption. However, taste is still one of the most important factor of decision for consumers regarding food products. Despite such importance of taste in decision‐making, most research on consumer senses still relies on traditional methods of surveying consumers, which are unable to measure the consumers' autonomic emotional reactions. The current paper uses a psychophysiological method to measure emotional arousal–electrodermal activity (EDA) and a self‐assessment manikin to measure pleasure. Emotions are then tested to assess their influence on perceived quality and willingness to buy (WTB). Findings show that NB are still perceived by consumers as superior, but consumers' WTB is not higher for NB. These results show that consumers' decisions are not always in favor of the product which is perceived to have a better quality which suggests that the “quality gap” is fading and the “branding gap” is gaining momentum.
Chemical Constituents from Citrus changshan‐huyou and Their Anti‐Inflammatory Activities
Authors: Hu Yu‐Hong , Liu Jin , Li Heng , Tang Wei , Li Xu‐Wen , Guo Yue‐Wei 
Published: September 2020

AbstractA systematically chemical investigation of Citrus changshan‐huyou Y.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid, nootkatone, scoparone, β‐sitosterol, 3,3′,4′,5,6,7,8,‐heptamethoxyflavone, nobiletin, tangeretin, naringin, hesperidin, neohesperidin, 3,5‐dihydroxyphenyl β‐D‐glucoside, β‐sitosterol‐D‐glucoside. The structure modification of the most abundant compound limonin further led to eight limonoid derivatives, including epi‐limonol, epi‐limonyl acetate, and six new compounds epi‐limonol A, limonol A, limonol B, epi‐limonol B, epi‐limonol C, epi‐limonol D, which enlarged the chemical diversity of limonin related limonoids. The structures of the new limonoid derivatives were identified by extensive spectroscopic analysis. In bioassay, all the isolates, the semi‐synthetic derivatives and the previously isolated limonoids in our natural product library were subjected for anti‐inflammatory activities evaluation, and several limonoids exhibited the inhibition of TNF‐α release.
An Efficient Strategy for the Chemo‐Enzymatic Synthesis of Bufalin Glycosides with Improved Water Solubility and Inhibition against Na+, K+‐ATPase
Authors: Liu Yan , Xu Wei , Huang Zhao‐He , Guo Jun , Jiang Ren‐Wang 
Published: September 2020

AbstractIn this study, bufalin was glycosylated by an efficient chemo‐enzymatic strategy. Firstly, 2‐chloro‐4‐nitrophenyl‐1‐O‐β‐D‐glucoside (sugar donors) was obtained by chemical synthesis. Then, the glycosylation of the bufalin was achieved with the synthesized sugar donor under the catalysis of two glycosyltransferases (Loki and ASP). Finally, two glycosides, i. e., bufalin‐3‐O‐β‐D‐glucopyranoside and bufalin‐3‐O‐[β‐D‐glucopyranosyl‐(1→2)‐β‐D‐glucopyranoside)], were obtained by preparative HPLC. Compared to our previously reported sole chemical (total yield 10 % in four steps) or enzymatic methods (30 %), our combined chemo‐enzymatic strategy in this article greatly improves the yields of monoglycoside (68 %) and diglycoside (21 %) and decreased the experimental cost (90 %). Furthermore, we tested the water solubility of these glycosides and found that the water solubilities of the two glycosides were 13.1 and 53.7 times of bufalin, respectively. In addition, the inhibitory activity of these glycosides against Na+, K+‐ATPase were evaluated. The mono‐glycosylated compound showed more potent activity than bufalin, while the diglycosylated compound was less potent.
In vivo Targeting of DNA Vaccines to Dendritic Cells via the Mannose Receptor Induces Long‐Lasting Immunity against Melanoma
Authors: Moku Gopikrishna , Vangala Swathi , Gulla Suresh Kumar , Yakati Venu 
Published: September 2020

AbstractHerein, we report effective, C‐type lectin mannose receptor (MR)‐selective, in vivo dendritic cell (DC)‐targeting lipid nanoparticles (LNPs) of a novel lipid‐containing mannose‐mimicking di‐shikimoyl‐ and guanidine head group and two n‐hexadecyl hydrophobic tails (DSG). Subcutaneous administration of LNPs of the DSG/p‐CMV‐GFP complex showed a significant expression of green fluorescence protein in the CD11c+ DCs of the neighboring lymph nodes compared to the control LNPs of the BBG/p‐CMV‐GFP complex. Mannose receptor‐facilitated in vivo DC‐targeted vaccination (s.c.) with the electrostatic complex of LNPs of DSG/pCMV‐MART1 stimulated long‐lasting (270 days post B16F10 tumor challenge) antimelanoma immunity under prophylactic conditions. Remarkably, under therapeutic settings, vaccination (s.c.) with LNPs of the DSG/pCMV‐MART1 complex significantly delayed melanoma growth and improved the survival of mice with melanoma. These findings demonstrate that this nonviral delivery system offers a resilient and potential approach to deliver DNA vaccines encoding tumor antigens to DCs in vivo with high efficacy.
Engineering of Thermostable β‐Hydroxyacid Dehydrogenase for the Asymmetric Reduction of Imines
Authors: Stockinger Peter , Schelle Luca , Schober Benedikt , Buchholz Patrick C. F. , Pleiss Jürgen , Nestl Bettina M. 
Published: September 2020

AbstractThe β‐hydroxyacid dehydrogenase from Thermocrinus albus (Ta‐βHAD), which catalyzes the NADP+‐dependent oxidation of β‐hydroxyacids, was engineered to accept imines as substrates. The catalytic activity of the proton‐donor variant K189D was further increased by the introduction of two nonpolar flanking residues (N192 L, N193 L). Engineering the putative alternative proton donor (D258S) and the gate‐keeping residue (F250 A) led to a switched substrate specificity as compared to the single and triple variants. The two most active Ta‐βHAD variants were applied to biocatalytic asymmetric reductions of imines at elevated temperatures and enabled enhanced product formation at a reaction temperature of 50 °C.
Anesthetic management of a neonate with an intrapericardial teratoma: a case report
Authors: Lu‐Boettcher Ying E. , Koppera Prabhat , Riegger Lori Q. 
Published: September 2020

AbstractIntrapericardial teratomas can exert mass effect on the cardiovascular and respiratory system. Adequate volume resuscitation and anticipation of cardiopulmonary collapse is paramount in the management of these patients in the operating room.
Hydrocarbon and Soot Oxidation over Cerium and Iron Doped Vanadium SCR Catalysts
Authors: Zheng Lei , Zimina Anna , Casapu Maria , Grunwaldt Jan‐Dierk 
Published: September 2020

AbstractV2O5−WO3/TiO2 (VWTi) catalysts are widely employed for selective catalytic reduction (SCR) of NOx. However, due to their poor thermal stability the application in diesel particulate filters (DPFs), i. e. 2‐way SCRonDPF is limited. In this study, the potential of Ce‐ and Fe‐doped VWTi systems for hydrocarbon and soot oxidation in addition to the SCR activity was systematically investigated for fresh and thermally aged samples. The formation of metal vanadates upon thermal aging, as identified by X‐ray diffraction, Raman and X‐ray adsorption spectroscopy, prevents drastic sintering of the support and maintains a high NOx−SCR and hydrocarbon oxidation activity. Additionally, the doped VWTi catalysts show a slight increase of the CO2 selectivity during hydrocarbon oxidation, which represents an important aspect for such multifunctional catalysts. Despite of the advantages, the formation of metal vanadates hinders the mobility of vanadium species and decreases the soot oxidation ability of the doped catalysts. Interestingly, a promising soot oxidation activity was identified for the VWTi−Fe sample after aging at 650 °C, which resulted in decomposition of the iron vanadate and generation of highly dispersed and mobile V2O5.
Catalytic Asymmetric Intermolecular Radical Aminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis
Authors: Wang Zhe , Cheng Jiang‐Tao , Shi Zhichao , Wang Na , Zhan Feng , Jiang Sheng‐Peng , Lin Jin‐Shun , Jiang Yuyang , Liu Xin‐Yuan 
Published: September 2020

AbstractA first catalytic enantioselective intermolecular radical aminotrifluoromethylation of alkene with hydrazine and Togni's reagent by Cu(I)/CPA cooperative catalysis has been reported, accessing diversely substituted CF3‐containing enantioenriched diarylmethylamines bearing an α‐tertiary stereocenter with high enantioselectivity and excellent chemoselectivity. The highly asymmetric induction of C−N bond formation between hydrazine and the carbocation intermediate was achieved by using a CPA catalyst via hydrogen‐bonding and ion pair interaction.
A Liu estimator for the beta regression model and its application to chemical data
Authors: Karlsson Peter , Månsson Kristofer , Kibria B.M. Golam 
Published: September 2020

AbstractBeta regression has become a popular tool for performing regression analysis on chemical, environmental, or biological data in which the dependent variable is restricted to the interval [0, 1]. For the first time, in this paper, we propose a Liu estimator for the beta regression model with fixed dispersion parameter that may be used in several realistic situations when the degree of correlation among the regressors differs. First, we show analytically that the new estimator outperforms the maximum likelihood estimator (MLE) using the mean square error (MSE) criteria. Second, using a 'simulation study, we investigate the properties in finite samples of six different suggested estimators of the shrinkage parameter and compare it with the MLE. The simulation results indicate that in the presence of multicollinearity, the Liu estimator outperforms the MLE uniformly. Finally, using an empirical application on chemical data, we show the benefit of the new approach to applied researchers.
What's in an Atom? A Comparison of Carbon and Silicon‐Centred Amidinium⋅⋅⋅Carboxylate Frameworks**
Authors: Boer Stephanie A. , Yu Li‐Juan , Genet Tobias L. , Low Kaycee , Cullen Duncan A. , Gardiner Michael G. , Coote Michelle L. , White Nicholas G. 
Published: September 2020

AbstractDespite their apparent similarity, framework materials based on tetraphenylmethane and tetraphenylsilane building blocks often have quite different structures and topologies. Herein, we describe a new silicon tetraamidinium compound and use it to prepare crystalline hydrogen bonded frameworks with carboxylate anions in water. The silicon‐containing frameworks are compared with those prepared from the analogous carbon tetraamidinium: when biphenyldicarboxylate or tetrakis(4‐carboxyphenyl)methane anions were used similar channel‐containing networks are observed for both the silicon and carbon tetraamidinium. When terephthalate or bicarbonate anions were used, different products form. Insights into possible reasons for the different products are provided by a survey of the Cambridge Structural Database and quantum chemical calculations, both of which indicate that, contrary to expectations, tetraphenylsilane derivatives have less geometrical flexibility than tetraphenylmethane derivatives, that is, they are less able to distort away from ideal tetrahedral bond angles.
Effect of virtual error sensor location for active sound quality control in a car cabin
Authors: Ryu Seokhoon , Kim Seonghyeon , Lee Young‐Sup 
Published: September 2020

SummaryA virtual error microphone‐based active sound quality control (VEM‐ASQC) algorithm is proposed to make engine sound quality better inside a car cabin in this study. In a single‐input and single‐output system, if a VEM is installed at either left or right ear, the sound pressure level (SPL) at the other ear can be fluctuated, and this leads the excessive SPL difference between the two ears when previous methods were applied. In this paper, an uncomplicated method that can make engine sounds at both left and right ears track the target engine sound levels with less errors and reduces the left‐right tracking error (TE) (in SPL) difference was investigated. The suggested VEM‐ASQC algorithm was implemented in an actual car for real‐time control experiment, and target profiles of nine engine orders were designed to control the sound quality actively. The control experiment showed that the proposed approach reduces the errors to track the target levels and the left‐right TE differences more compared to those by the previous methods.
p.P476S mutation of RBPJL inhibits the efficacy of anti‐PD‐1 therapy in oesophageal squamous cell carcinoma by blunting T‐cell responses
Authors: Miao Lei , Wei Xiao‐Li , Zhao Qi , Qi JingJing , Ren Chao , Wu Qi‐Nian , Wei Da‐Liang , Liu Jia , Wang Feng‐Hua , Xu Rui‐Hua 
Published: September 2020

AbstractObjectivesAnti‐PD‐1 immune checkpoint blockade represents the onset of a new era in cancer immunotherapy. However, robust predictors are necessary for screening patients with immune checkpoint‐responsive oesophageal squamous cell carcinoma (ESCC).MethodsWe obtained biopsy samples from an ESCC patient with mixed responses. The expression of CD4, CD8, CD68, PD‐L1, RBPJL and IL‐16 was analysed by immunohistochemistry, and the correlation with prognostic value was obtained from the GEPIA portal. T‐cell functions were examined by flow cytometry, MTS and transwell assays. The secreted cytokines were identified using an Inflammation Array Kit. The concentration of soluble IFN‐γ was measured by enzyme‐linked immunosorbent assay. The clinical benefit of RBPJL was examined in a PBMC xenograft mouse model.ResultsThe patient had an exceptional clinical response with shrinkage of the primary oesophageal and lung metastatic lesions as well as enlargement of liver metastatic lesions after toripalimab monotherapy. Four liver‐specific gene mutations were identified. RBPJL showed better response to toripalimab in the PBMC cell‐derived xenograft (CDX) ESCC model. Conditional medium from RBPJL overexpression induced chemotaxis and proliferation of T lymphocytes, as well as Th2/Th1 differentiation through the RBPJL‐NF‐κB‐IL‐16 axis in vitro. These functions were all inhibited by the p.P476S mutation of RBPJL (RBPJL (p.P476S)).ConclusionsWe report for the first time that RBPJL (p.P476S) promotes tumor growth in ESCC and inhibits the efficacy of anti‐PD‐1 therapy through blunting T‐cell responses. Our findings provide a potential new predictor for evaluating the efficacy of anti‐PD‐1 therapy in ESCC patients.
Effectiveness of internet‐based guided self‐help for binge‐eating disorder and characteristics of completers versus noncompleters
Authors: Jensen Esben Skov , Linnet Jakob , Holmberg Trine Theresa , Tarp Kristine , Nielsen Jakob Hyldig , Lichtenstein Mia Beck 
Published: September 2020

AbstractObjectiveBinge‐eating disorder (BED) is characterized by recurrent episodes of binge eating, accompanied by a lack of control and feelings of shame. Online intervention is a promising, accessible treatment approach for BED. In the current study, we compared completers with noncompleters in a 10‐session guided internet‐based treatment program (iBED) based on cognitive behavioral therapy.MethodsAdults (N = 75) with mild to moderate BED participated in iBED with weekly written support from psychologists. Participants were compared on the Eating Disorder Examination Questionnaire (EDE‐Q), diagnostic criteria for BED (BED‐Q), major depression inventory (MDI), quality of life (EQ‐5D‐5L), body mass index (BMI) and sociodemographic variables.ResultsMinor differences were observed between completers and noncompleters on depression. No differences were found in BED‐symptoms, BMI, and sociodemographic variables. Participants who completed treatment showed large reductions in eating disorder pathology.DiscussionMore research is needed to determine risk factors for attrition or treatment outcome in internet‐based interventions for BED. It is suggested that iBED is an efficient intervention for BED. However, more studies of internet‐interventions are needed.
Mimicry and mitonuclear discordance in nudibranchs: New insights from exon capture phylogenomics
Authors: Layton Kara K. S. , Carvajal Jose I. , Wilson Nerida G. 
Published: September 2020

AbstractPhylogenetic inference and species delimitation can be challenging in taxonomic groups that have recently radiated and where introgression produces conflicting gene trees, especially when species delimitation has traditionally relied on mitochondrial data and color pattern. Chromodoris, a genus of colorful and toxic nudibranch in the Indo‐Pacific, has been shown to have extraordinary cryptic diversity and mimicry, and has recently radiated, ultimately complicating species delimitation. In these cases, additional genome‐wide data can help improve phylogenetic resolution and provide important insights about evolutionary history. Here, we employ a transcriptome‐based exon capture approach to resolve Chromodoris phylogeny with data from 2,925 exons and 1,630 genes, derived from 15 nudibranch transcriptomes. We show that some previously identified mimics instead show mitonuclear discordance, likely deriving from introgression or mitochondrial capture, but we confirm one “pure” mimic in Western Australia. Sister–species relationships and species‐level entities were recovered with high support in both concatenated maximum likelihood (ML) and summary coalescent phylogenies, but the ML topologies were highly variable while the coalescent topologies were consistent across datasets. Our work also demonstrates the broad phylogenetic utility of 149 genes that were previously identified from eupulmonate gastropods. This study is one of the first to (a) demonstrate the efficacy of exon capture for recovering relationships among recently radiated invertebrate taxa, (b) employ genome‐wide nuclear markers to test mimicry hypotheses in nudibranchs and (c) provide evidence for introgression and mitochondrial capture in nudibranchs.
The role of sacubitril/valsartan in the management of cardiac resynchronization therapy non‐responders: a retrospective analysis
Authors: Chun Kyeong‐Hyeon , Oh Jaewon , Yu Hee Tae , Lee Chan Joo , Kim Tae‐Hoon , Uhm Jae Sun , Pak Hui‐Nam , Lee Moon‐Hyoung , Joung Boyoung , Kang Seok‐Min 
Published: September 2020

AbstractAimsOptimal medical therapy after cardiac resynchronization therapy (CRT) implantation is important in heart failure (HF) with reduced ejection fraction (HFrEF) patients. Although sacubitril/valsartan (SV) is a mainstay in the treatment of HFrEF, its efficacy in the management of CRT non‐responders has not been emphasized. We aimed to investigate the efficacy of SV in CRT non‐responders.Methods and resultsWe analysed 175 HFrEF patients who received CRT implantation between January 2010 and January 2019. CRT responder was defined as a decrease in left ventricular (LV) end‐systolic volume > 15% on echocardiography 6 months after implantation. Medical records were retrospectively reviewed. Patients underwent follow‐up for HF rehospitalization, heart transplantation (HT), implantation of a LV assistant device (LVAD), cardiac death, and all‐cause death. Among the study population, 164 patients were evaluated for CRT response; 54 (33%) were CRT non‐responders. Four patients (6%) who received SV before CRT implantation were excluded, leaving 50 patients for analysis. Twenty‐two non‐responders (44%) received SV. There was no significant difference in baseline characteristics between SV users and non‐users (n = 28). During follow‐up, SV users had significantly lower incidence of all‐cause death [1 (5%) vs. 10 (36%), P = 0.022] and tended to have lower HF rehospitalization [6 (27%) vs. 16 (57%), P = 0.068] and cardiac death (including HT and LVAD implant) [2 (9%) vs. 10 (36%), P = 0.064]. Kaplan–Meier survival analysis revealed that SV use was associated with a lower risk of cardiac death (including HT and LVAD implant) (log‐rank P = 0.029).ConclusionsSV treatment was related to a lower incidence of cardiac death including HT and LVAD implant in CRT non‐responders. The optimization of HF management, including SV, should be considered in CRT non‐responders.