bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Highly Biocompatible Polyoxotungstate with Fenton‐like Reaction Activity for Potent Chemodynamic Therapy of Tumors
Authors: Xiao Hui‐Ping , Du Man‐Yi , Sun Xian‐Bin , Xu Ruo‐Fei , Li Dong‐Miao , Yue Sheng‐Nan , Cai Ping‐Wei , Sun Rong‐Zhi , Zhang Zi‐Zhong , Huang Xing , Li Xin‐Xiong , Gao Yu , Zheng Shou‐Tian 
Published: December 2024

AbstractIntegrating Fenton chemistry and nanomedicine into cancer therapy has significantly promoted the development of chemodynamic therapy (CDT). Nanoscale polyoxometalates (POMs), with their reversible redox properties, exhibit promising potential in developing outstanding CDT drugs by exploring their Fenton‐like catalytic reactivity in tumor environments. However, such research is still in its infancy due to the challenges of acquiring POMs that are both easily prepared and possess ideal therapeutic effects, physiological solubility, biocompatibility and safety. In this work, we report the synthesis of a new crystalline antimonotungstate {Dy2Sb2W7O23(OH)(DMF)2(SbW9O33)2} (1, DMF=N, N‐dimethylformamide) with gram‐scale high yield via a facile “one‐pot” solvothermal reaction. 1 exhibits not only a soluble and water‐stable POM nanocluster, but also excellent catalytic activity for hydroxyl radical‐generating Fenton‐like reactions. Further biomedical studies reveal that 1 can trigger cell apoptosis and promote lipid peroxidation, exhibiting high cytotoxicity and selectivity towards B16‐F10 mouse melanoma cancer cells with an IC50 value of 4.75 μM. Especially, 1 can inhibit melanoma growth in vivo with favorable biosafety, achieving a 5.2‐fold reduction in tumor volume and a weight loss of 76.0 % at the dose of 70 μg/kg. This research not only demonstrates the immense potential of antimonotungstates in CDT drug development for the first time but also provides new insights and directions for the development of novel anticancer drugs.
Toward Rhenium‐Based Circularly Polarized OLEDs Using Tailored Chiral Re(CO)3 Emitters
Authors: Davydova Maria P. , Xu Ting , Agafontsev Alexander M. , Meng Lingqiang , Wolff Mariusz , Petyuk Maxim Yu. , Bagryanskaya Irina Yu. , Berezin Alexey S. , Tkachev Alexey V. , Meng Hong , Artem'ev Alexander V. 
Published: December 2024

AbstractChiral rhenium(I) emitters exhibiting circularly polarized phosphorescence (CPP) are an attractive mainstay for CP organic light‐emitting diodes (CP‐OLEDs). However, the efficiency of such emitters is not ideal, and they have never been explored for circularly polarized electroluminescence (CPEL) applications. Here, we have tailored robust chiral Re(I) complexes with improved CPP properties, and demonstrated CPEL from rhenium emitters for the first time. Two pairs of enantiomeric Re(I) complexes have been synthesized by introducing of one or two chiral menthol groups into 1,10‐phenanthroline unit (phen) of archetypical emitters [ReBr(CO)3(phen)]. The designed complexes exhibit a yellow CPP with enhanced |glum| factors (up to 2.5×10−2) and a good quantum efficiency. The pioneering Re(I)‐based CP‐OLEDs (based on the obtained emitters) exhibit yellow CPEL with |gEL| factors of up to 6.2×10−3 and a maximal external quantum efficiency of 13.2 %. This work highlights the good potential of chiral Re(I) emitters for CPEL applications, and opens up a new shortcut to CPP‐active Re(I) complexes.
Atomistic Transport Mechanisms in Lithium Salt‐Doped Ionic Covalent Organic Framework Electrolytes
Authors: Cheng Lei , Deng Yanhao , Huang Jun , Zhang Zhengyang , Duan Huanan , Kim Yoonseob , Wang Yanming 
Published: December 2024

AbstractIonic covalent organic frameworks (iCOFs) have garnered significant attention as potential single‐ion conductive solid‐state electrolytes, where researchers have made substantial efforts in designing iCOF‐based composites, aiming to improve their intrinsic low conductivity. One successful case is to fill iCOF channels with lithium salts, such as lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). However, the ion transport mechanisms in these composite electrolytes are still largely unknown, hindering their further improvement. Here molecular dynamics simulations were employed to systematically predict the ion diffusivity in iCOF (e. g., TpPa‐SO3Li COF)‐LiTFSI composite electrolytes with varying LiTFSI compositions at different temperatures. A positive correlation was observed between Li+ diffusivity and LiTFSI:iCOF ratio, which was also verified by our experiments. Interestingly, the Li+ diffusion energy barrier obtained by the Arrhenius equation exhibited nearly no dependency on the LiTFSI concentration, indicating the importance of temperature‐insensitive microstructural‐related factors. Radial distribution functions revealed that with a higher LiTFSI proportion, the coordination number of SO3− decreases, while that of TFSI− increases, suggesting a competition between these two species in the Li+ solvation shell. Furthermore, configurational entropy and bond orientational order parameter calculations examined the degree of disorder in the Li+ solvation structure. These results should improve our mechanistic understanding of iCOF‐based electrolytes.
Creating a System of Dual Regulation of Translation and Transcription to Enhance the Production of Recombinant Protein
Authors: Li Xin , Shi Peng‐Wei , Du Fei , Zhang Zi‐Xu , Li Zi‐Jia , Wu Na , Yang Guang , Ma Wang , Sun Xiao‐Man 
Published: December 2024

ABSTRACTWhen constructing cell factories, it is crucial to reallocate intracellular resources towards the synthesis of target compounds. However, imbalanced resource allocation can lead to a tradeoff between cell growth and production, reducing overall efficiency. Reliable gene expression regulation tools are needed to coordinate cell growth and production effectively. The orthogonal translation system, developed based on genetic code expansion (GCE), incorporates non‐canonical amino acids (ncAAs) into proteins by assigning them to expanded codons, which enables the control of target protein expression at the translational level in an ncAA‐dependent manner. However, the stringency of this regulatory tool remains inadequate. This study achieved strict translational‐level control of the orthogonal translation system by addressing the abnormal leakage caused by the arabinose‐inducible promoter. Further validation was conducted on the relationship between ncAA concentration and expression level, as well as the host's adaptability to the system. Subsequently, the system's applicability across multiple Escherichia coli hosts was verified by examining the roles of RF1 (peptide chain release factor 1) and endogenous TAG codons. By combining this strategy with inducible promoters, dual‐level regulation of target gene expression at both transcriptional and translational levels was achieved and the dynamic range was further increased to over 20‐fold. When using ncAA to control the expression of T7 RNA polymerase (T7 RNAP), the leakage expression was reduced by 82.7%, mitigating the low production efficiency caused by extensive leakage in the T7 system. As proof of concept, the strategy enhanced the production of alcohol dehydrogenase (ADH) by 9.82‐fold, demonstrating its excellent capability in controlling gene expression in developing cell factories.
Assessment of Public Stigma, Mental Health Literacy, and Help‐Seeking Intentions Based on Different Dimensions of Obsessive–Compulsive Content: A Study of the Spanish Mental Health‐Naïve Population
Authors: Chaves Antonio , Arnáez Sandra , Roncero Maria , García‐Soriano Gemma 
Published: December 2024

ABSTRACTBackgroundObsessive–compulsive (OC) disorder is a debilitating disorder with a high delay in help‐seeking that could be associated with two barriers that may differ between OC content dimensions: public stigma and mental health literacy.ObjectivesWe aim to describe and analyze the differences among OC content dimensions in public stigma, social distance desire, mental health literacy, and help‐seeking intention in a sample of the mental health‐naïve population.MethodsA total of 487 participants from the Spanish community with no previous knowledge of or experience with OCD were randomly allocated one of six vignettes describing a person with OC symptoms of one out of six contents (i.e., aggression/harm; sexual; religious/blasphemous/immoral; contamination/washing; doubts/checking; or superstition/symmetry/order). After reading the vignette, participants completed the following questionnaires associated with their vignette: Attribution Questionnaire, General Help‐Seeking Questionnaire, Social Distance Scale, and Mental Health Literacy Questionnaire.ResultsThere were significant differences among OC content dimensions on the variables of interest. Aggression/harm OC content was associated with the highest public stigma and discriminating desire, and together with the religious/blasphemous/immoral OC contents were associated with the highest social distance desire. Although no differences appear between contents on intention to seek for formal treatment, participants would request less informal support for their sexual OC content than for the other categories. Contamination, doubts/checking, and superstition/symmetry/order OC contents were more frequently identified as OCD, although only around 50% or less of the sample identified the sexual, superstition/symmetry/order, doubts/checking, and religious/blasphemous/immoral OC contents as a mental health problem.ConclusionsInterventions to reduce stigma and increase help seeking are necessary and should consider OC heterogeneity.
Metabolomic Diversity and Defensive Phenolic Compounds in Cloud Forest Ferns
Authors: Castrejón‐Varela Alejandra , Monribot‐Villanueva Juan L. , Pérez‐García Blanca , Moya‐Hernández Araceli , Guerrero‐Analco José A. , Mehltreter Klaus 
Published: December 2024

ABSTRACTThe few current metabolomic studies on ferns are mostly restricted to a single species or focused on specific compounds. We performed an untargeted metabolomic study on six of the most common fern species from the cloud forest, followed by a targeted analysis of 64 phenolic compounds, many of which have been associated with herbivore defense. The untargeted analysis revealed a total of 232 putative identified metabolites from 463 to 1427 signals per fern species, each with its proper chemical signature but not necessarily correlated to their phylogenetic relationship. The flavonoid, flavone, and flavonol biosynthesis were the most expressed pathways in all species except for Marattia laxa. Fern species also differed strongly in the concentrations of the 10 detected phenolic compounds. Our results show that ferns, including the most ancestral species, such as M. laxa, display a high metabolomic diversity comparable to seed plants. Each fern species held a different combination of defensive phenolic compounds. Further research is needed to explore the metabolic diversity, to identify the biochemical defenses of ferns, and, in particular, to detect the chemical compounds that act against their specific herbivorous insects in the cloud forest ecosystem.
Unveiling 8,12‐Dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via Fibronectin 1 Downregulation
Authors: Xi Xiuli , Qi Yuxin , Zhang Mingli , Yang Peng , Huang Xueshuang 
Published: December 2024

ABSTRACTThis study investigated the effects of 8,12‐dimethoxysanguinarine (DSG) from Eomecon chionantha Hance on the malignant biological activity of breast cancer cells. RNA‐sequencing measure analysis revealed that metastasis‐related genes were significantly downregulated in DSG‐treated MCF‐7 cells. DSG significantly inhibits the migration ability in MCF‐7 cells. Molecular docking studies demonstrated significant interactions between DSG and the Fibronectin 1 (FN1) protein, with a binding energy of ‐8.91 kcal/mol. Additionally, FN1 messenger RNA expression was significantly upregulated in 1085 breast tumor samples compared to normal tissue in the Cancer Genome Atlas Breast Invasive Carcinoma Collection dataset. DSG also suppressed MCF‐7 cell metastasis by downregulating FN1 expression. Furthermore, DSG was identified as a promising candidate based on absorption distribution metabolism excretion toxicity and drug‐likeness assessments. Combination studies indicated that DSG synergized with the conventional chemotherapeutic agent doxorubicin to suppress MCF‐7 cell migration, as confirmed by wound‐healing and transwell assays. Collectively, these findings suggest that DSG may serve as a potential agent for inhibiting breast cancer cell metastasis by decreasing FN1 expression.
Formation of Poly‐L–Lysine‐Porphyrin Derivative Complex Exhibiting Diminished Dark Toxicity in Aqueous Solutions and High Photodynamic Activity
Authors: Egashira Yusuke , Kono Nanami , Tarutani Naoki , Katagiri Kiyofumi , Hino Shodai , Yamana Keita , Kawasaki Riku , Ikeda Atsushi 
Published: December 2024

AbstractPoly‐L–lysine (PLL) displays a high solubilizing ability for hydrophobic guest molecules, and when in complexes with guest molecules, it exhibits a high intracellular uptake. However, its high cytotoxicity, originating from its cationic character, significantly limits its applications in biological and medicinal chemistry. In this study, the amount of free PLL in an aqueous solution of a PLL–porphyrin complex was immensely reduced, resulting in considerably lower dark toxicity than that of the free PLL. Furthermore, the PLL–porphyrin complex exhibited high photodynamic activity under photoirradiation at 610–740 nm.
Surgical Explantation of an Amplatzer Device for Patent Foramen Ovale Closure in a Patient With Nickel Allergy: A Case Report
Authors: Kumar Ujjawal , Aslam Usman , Cooper Anthony , Khalpey Zain 
Published: December 2024

ABSTRACTPatent foramen ovale (PFO) closure using percutaneous devices, such as the Amplatzer occluder, is a common treatment for patients with a history of cryptogenic stroke or transient ischemic attack (TIA). Although generally well‐tolerated, some patients may develop adverse reactions to the device materials, particularly in the presence of a nickel allergy. Symptoms can include chest pain, rashes, and migraines, which may necessitate surgical removal of the device. In such cases, careful surgical planning and execution are essential to ensure successful outcomes and symptom resolution. We present the case of a 39‐year‐old female with existing PFO closure using an Amplatzer device, who developed severe, persistent atypical chest pain radiating to her upper extremities and occasional migraines 1 month after Amplatzer implantation. Patch testing confirmed a nickel allergy, prompting a referral to our service for surgical explantation of the device. The patient underwent Amplatzer device removal and reconstruction of the interatrial septum via sternotomy. The surgical technique involved meticulous excision of the device while preserving maximal septal tissue, allowing for primary closure of the interatrial septum without the need for a pericardial patch. Intraoperatively, significant scar tissue and inflammation were observed surrounding the device and atrial septal tissue, necessitating careful excision while preserving healthy tissue. The left atrial appendage was oversewn using a polypropylene suture for thromboembolism prophylaxis. Amniotic membrane allograft and autologous platelet‐rich plasma were applied to promote wound healing, with specialized suture tapes used for chest closure to avoid using stainless steel sternal wires (the most common alloy, 316 L surgical steel contains around 15% nickel) and minimize the risk of sternal complications. The patient tolerated the procedure well, with complete resolution of symptoms following device removal. At follow‐up, she reported improved exercise tolerance, enhanced quality of life, and was able to discontinue her pregabalin medication after 30 months of use (600 mg once daily). She returned to work with light duties 6 weeks postoperatively. This case highlights the importance of preoperative allergy testing to consider nickel allergy in patients before implanting devices such as an Amplatzer, as well as after considering de novo nickel sensitization as a potential cause when such symptoms develop after implantation. This case also highlights the value of surgical intervention in alleviating symptoms and optimizing patient outcomes in cases of device‐related complications.
Paradoxical Infarction? Inferior STEMI With Unexpected Discovery of ASD in an Oncology Patient: A Case of Combined Percutaneous Intervention
Authors: Balbuena Madera Miguel Angel , Garcia Garcia Juan Francisco , Vargas Cruz Antonio , Aquino Bruno Heberto , González Jasso Jesús Guadalupe 
Published: December 2024

ABSTRACTThis case report explores the management of a 56‐year‐old female oncology patient presenting with acute ST‐elevation myocardial infarction (STEMI) and an incidental atrial septal defect (ASD). The patient, with a history of rectal cancer and hypothyroidism, experienced acute chest pain and dyspnea. She was diagnosed with an inferior STEMI and underwent percutaneous coronary intervention (PCI) with the placement of three medicated stents in the right coronary artery. During hospitalization, an echocardiogram revealed a significant ostium secundum ASD. Angiography indicated thrombi, suggesting a potential paradoxical embolism. Percutaneous ASD closure was performed during the same hospital stay, leading to a favorable clinical course without immediate complications. This case highlights the importance of a multidisciplinary approach and comprehensive evaluation in managing complex cardiovascular conditions, particularly in patients with increased thrombotic risk due to malignancy.
Modified Fly Ash: An Eco‐Friendly, Cost‐Free, and Efficient Iron‐Based Catalyst for Ammonia Decomposition to COx‐Free Hydrogen
Authors: Sekizkardeş Büşra , Kurtoğlu‐Öztulum Samira F. 
Published: December 2024

AbstractFly ash (FA), an industrial waste produced in large amounts, is rich in metal oxides such as Al2O3, SiO2, and Fe2O3, making it an ideal candidate for use as a catalyst in ammonia decomposition. However, FA's surface area is very low (<1.0 m2 g−1), limiting its potential. This study investigates the modification of FA by calcination at various temperatures (550, 700, and 1000 °C), HCl treatment, and HCl treatment followed by calcination at 500 °C to convert FA into a catalyst by utilizing its iron content as active sites. The catalyst obtained by treating FA with HCl at 220 °C, calcining at 500 °C, reducing in H2 at 700 °C, and activating in ammonia at 700 °C achieved 86.0% ammonia conversion at a reaction temperature of 700 °C and a space velocity of 30,000 mL NH3 h−1 gcat−1, remaining stable for 140 h following an induction period of 30 h. Enhanced textural properties (18.5 m2 g−1), elimination of S and Cl impurities, and the formation of relatively small Fe crystallites (23.8 nm determined by Scherrer equation and 24.0 nm measured by transmission electron microscopy (TEM)) when reduced in H2 were responsible for this performance.
Luminescence and Generation of Reactive Oxygen Species in Solution by Ta6Br12 Clusters
Authors: Hernández Jhon Sebastián , Atienzar Pedro , Shamshurin Maxim , Benassi Enrico , Sokolov Maxim N. , Feliz Marta 
Published: December 2024

AbstractAn intrinsic metal cluster NIR‐II emission of the {Ta6Br12}2+ aqua/hydroxocomplexes was determined in aqueous solutions under inert atmosphere. The photoluminescence (PL) is enhanced in D2O, and the lifetime scale expands from nanoseconds to microseconds. Possible cluster emission transitions have been assigned and analyzed from a computational perspective. In the presence of O2, the cluster compound kept its robustness but showed partial quenching of the PL. Stern‐Volmer and laser‐flash photolysis studies confirmed that quenching is mainly associated with O2 diffusion. Laser‐flash photolysis experiments showed that singlet oxygen (1O2) was not detected under measurement conditions. Generation of peroxide and superoxide radical species after irradiation in D2O was confirmed by using luminol as a probe, whereas no hydroxide radical species were detected as evidenced by the emission of the 3‐coumarin carboxylic acid (3‐CCA) molecular sensor.
Luminescent Mechanochromism of a Platinum Complex with Four Monodentate Ligands Governed by Intramolecular Interactions Between Ligands
Authors: Seki Tomohiro , Ishikawa Rintaro 
Published: December 2024

AbstractA platinum complex equipped with 3‐methylbenzofuryl groups was prepared and its crystal structure and emission properties were investigated. This platinum complex has two distinctly emissive polymorphs: a blue‐emissive polymorph with low intensity and a brightly green‐emissive polymorph. Upon mechanical stimulation, the blue‐emitting phase is converted to green‐emitting powder through a crystal‐to‐crystal phase transition. Structure analyses indicated that intramolecular interactions between ligands control the phase‐transition behavior and the emission properties.
Demographic and Treatment Analysis of Periosteal Osteosarcoma
Authors: Larkins Michael C. 
Published: December 2024

ABSTRACTBackground and AimsPeriosteal osteosarcoma (PO) is a rare bone cancer that makes up between 1% and 6% of osteosarcomas. No epidemiological survey of the United States has been conducted to study this disease, and most of the literature is limited to single‐center analyses and case reports. We seek to perform the first such assessment.MethodsThe Surveillance, Epidemiology, and End Results (SEER) Program was queried for patients with primary PO (ICD‐O‐3 code 9193/3). Analysis of demographic, disease, and treatment variables was conducted via Fisher's exact test and 20‐year cause‐specific survival (20y CSS) was assessed via logrank analysis.ResultsFifty‐four patients with PO were identified; median age was 20–24 years at diagnosis. Multivariate analysis demonstrated surgery provided 20y CSS benefit (hazard ratio [HR] = 0.08, p = 0.040) while chemotherapy (CTX) did not (p = 0.29); however, given the limited number of events (n = 11), recalculation of Cox regression for each variable demonstrated significance only with race (p = 0.026). Younger patients were more likely to be diagnosed with PO of the appendicular skeleton compared to the axial skeleton (p = 0.038). Mean survival time was greater among patients diagnosed with appendicular PO (16.0 years [14.2, 17.9]) compared to axial PO (10.9 years [9.5, 12.4]). Stage‐stratified survival analysis demonstrated surgery alone was non‐inferior to surgery with the addition of CTX (local disease: p = 0.37; regional disease: p = 0.85).ConclusionAxial PO is associated with decreased mean 20y CSS compared to appendicular PO, though in general, appendicular PO is more common than axial PO. In keeping with current literature, treatment of PO with CTX in addition to surgery should be reserved for high‐risk patients, though its use in the treatment of PO is questionable.
Photoelectrochemical Investigation of Hole Scavengers for Photocatalytic Hydrogen Evolution Reaction on Perovskite‐Type Niobate Nanosheets
Authors: Yilmaz Bengisu , Ünal Uğur 
Published: December 2024

AbstractHole‐scavengers are a crucial part of particulate photocatalytic systems. The use of hole‐scavengers increases the photocatalytic activity by preventing electron‐hole recombination. The holes are used in photo‐oxidation of the hole‐scavenger molecules increasing the probability of electrons involved in photoreduction of water. In this study, different hole‐scavengers utilized in photocatalytic water splitting reaction were tested. The impact of different hole scavengers on photocatalytic reactions were investigated on [Ca2Nb3O10]− 2D nanosheets mechanistically. Cyclic voltammetry and chronoamperometry tests were employed to assess the impact of hole scavengers on photocatalytic efficiency. The photoelectrochemical tests agree with the results of the photocatalytic reactions. Methanol and EDTA give the largest oxidation photocurrent and the best photocatalytic activity.