bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESSENTIAL DRUG MANAGEMENT AT RSU KARSA HUSADA BATU: POLICY IMPLEMENTATION
Authors: Haksama Setya , Istanti Yeni Farida , Purnomo Windhu , Supriyanto Stefanus , Arifin Samsul , Anggraini Tries , Prijambodo Tjatur , Wulandari Anis 
Published: October 2020

Coordination in hospital is important process needed to reach the organization’s goals. One of the process that need coordination among cross-functional unit is essential drug procurement. The essential drug in Karsa Husada Batu Public Hospital (RSU Karsa Husada Batu) were often in out of stock condition in some specific kinds of drug. The average of essential drug out of stock between year of 2017 until the first semester of 2018 reached 33,73%. This number was far from the ideal standard of 0% out of stock condition. This research was aimed to give recommendation for a better coordination of essential drug management. The study used quantitative research. The population in this research was all hospital staff who participate in essential drug procurement in Karsa Husada Batu. Public Hospital. There were 29 samples as the respondents in this research. The variables in this research were frequently communication, timely communication, accurately communication, problem solving communication, shared knowledge, mutual respect, and shared goals. The result from the study showed that communication reached good result consist of frequently communication is good (69,00%), timely communication is good (65,50 %), accurately communicationis good (79,30%), problem solving communication is good (69,00%), shared knowledge is good (58,62%), but the mutual respect is not good (58,60%), and shared goals is not good (65,52%).
Do open journals get cited more in government policy?
Authors: Adie Euan 
Published: October 2020

There's a clear - if not completely understood - download and citation advantage for open access articles. We investigate whether or not this holds true for citations outside of the scholarly literature, specifically for references to scholarly work in government white papers, guidelines and other policy documents. Does making an article more available mean that it's more likely to have a policy impact?
We follow up with a list of strategies different journals and publishers have adopted to make sure that the research they publish reach the right policymakers at the right time, as well as a brief discussion on the role of preprints and review articles.
Fecal microbiota in client-owned obese dogs changes after weight loss with a high-fiber-high-protein diet
Authors: Bermudez Sanchez Sandra , Pilla Rachel , Sarawichitr Benjamin , Gramenzi Alessandro , Marsilio Fulvio , Steiner Joerg M. , Lidbury Jonathan A. , Woods Georgiana R.T. , German Alexander J. , Suchodolski Jan S. 
Published: October 2020

BackgroundThe fecal microbiota from obese individuals can induce obesity in animal models. In addition, studies in humans, animal models and dogs have revealed that the fecal microbiota of subjects with obesity is different from that of lean subjects and changes after weight loss. However, the impact of weight loss on the fecal microbiota in dogs with obesity has not been fully characterized.MethodsIn this study, we used 16S rRNA gene sequencing to investigate the differences in the fecal microbiota of 20 pet dogs with obesity that underwent a weight loss program. The endpoint of the weight loss program was individually tailored to the ideal body weight of each dog. In addition, we evaluated the qPCR based Dysbiosis Index before and after weight loss.ResultsAfter weight loss, the fecal microbiota structure of dogs with obesity changed significantly (weightedANOSIM;p = 0.016,R = 0.073), showing an increase in bacterial richness (p = 0.007), evenness (p = 0.007) and the number of bacterial species (p = 0.007). The fecal microbiota composition of obese dogs after weight loss was characterized by a decrease in Firmicutes (92.3% to 78.2%,q = 0.001), and increase in Bacteroidetes (1.4% to 10.1%,q = 0.002) and Fusobacteria (1.6% to 6.2%,q = 0.040). The qPCR results revealed an overall decrease in the Dysbiosis Index, driven mostly due to a significant decrease inE. coli(p = 0.030), and increase inFusobacteriumspp. (p = 0.017).ConclusionThe changes observed in the fecal microbiota of dogs with obesity after weight loss with a weight loss diet rich in fiber and protein were in agreement with previous studies in humans, that reported an increase of bacterial biodiversity and a decrease of the ratio Firmicutes/Bacteroidetes.
Immune cell landscape analysis reveals prognostic immune cells and its potential mechanism in squamous cell lung carcinoma
Authors: Wang Yongyong , Guo Jianji 
Published: October 2020

Background
Squamous cell lung carcinoma (LUSC) was closely associated with smoking which was known to have a distant immunosuppression effect. In this study, we aimed to explore the relationship between immune cells and clinical outcomes of LUSC patients with smoking history.

Methods
The immune cell infiltration and RNA expression profiles of LUSC patients were collected from The Cancer Genome Atlas (TCGA). Then, the correlation between immune cell infiltration and clinical characteristics was explored. According to the level of immune cell infiltration, LUSC patients with smoking history were divided into high or low group to screen the differentially expressed lncRNAs and mRNAs. The prediction of target genes was performed by miRanda. Finally, the prognostic value of a certain signature was confirmed in an independent dataset.

Results
Higher abundance of tumor-infiltrating T follicular helper (Tfh) cells together with a lower abundance of resting memory CD4 T cells had been found in LUSC current reformed smokers for ≤15 years and current smoking patients. Moreover, Tfh cell infiltration was not only associated with better overall survival (OS) but also varied from different degrees of TNM stage. Low expression of lncRNA PWRN1 and its potential regulating genes DMRTB1, PIRT, APOBEC1, and ZPBP2 were associated with better OS. Combining PWRN1 and four regulating genes as a signature, patients with higher-level expression of the signature had shorter survival time in not only the TCGA but also in the GEO dataset.

Conclusions
It was found that Tfh cells presented higher infiltration in LUSC current reformed smokers for ≤15 years and current smokers, while resting memory CD4 T cells had lower infiltration. The signature consisting of PWRN1 as well as its predicted targeted mRNAs was dysregulated in different levels of Tfh cell infiltration and might indicate patients’ OS.
Suitability of Usuma Dam Water for Domestic Use in Federal Capital Territory, Abuja, Nigeria
Authors: Omolori Sani Mustapha , Danjuma Marcus , Joshua Magaji 
Published: October 2020

The quality of water sources should be tested regularly for various parameters of interest to ensure it meet the standard qualities required for intended use(s). Thus, the suitability of Usuma dam water for domestic use in Nigeria’s Federal Capital Territory Abuja was assessed. The objectives were to assess the properties of Usuma dam water and ascertain its suitability for domestic purpose. A total of thirty (30) water samples were fetched directly. Ten (10) samples each from upstream, downstream and middle were collected. Precautions were taken to prevent sample contamination. Data collected were analyzed as follows: The water properties was analyzed using range and mean, suitability of water properties for domestic purpose was analyzed by comparing range and mean values with Nigerian Standard for Drinking Water Quality (NSDWQ) and the World Health Organization (WHO) standard for domestic uses. Result showed that water sample were slight acidic (6.83), EC was low (122-180 µs/cm3), TDS (120-144 Mg/l), TSS (1.2-1.7 Mg/l, turbidity (0.29-5.37 Mg/l,) total hardness (7.18-40.46 Mg/l) DO (3.8-4.7 Mg/l), BOD (2.2-4.21 Mg/l), and (25.6-55.4 Mg/l). Minerals nutrients (Ca, Mg, Cl-,Na, K, NO-3 and PO-4. ) in water samples were lower than regulatory standard while heavy metals (Fe, Si, Zn, Pb, Cr, Cd, Cu, Mn, F and B) were relatively higher than regulatory standard. It was concluded that water from Usuma dam are not safe for domestic purpose especially drinking.
Fuzzy Alexandrov Topologies Associated to Fuzzy Interval Orders
Authors: Bosi Gianni , Panozzo Chiaramaria , Zuanon Magal`ı Ernestine 
Published: October 2020

We characterize the fuzzy T0 - Alexandrov topologies on a crisp set X, which are associated to fuzzy interval orders R on X. In this way, we generalize a well known result by Rabinovitch (1978), according to which a crisp partial order is a crisp interval order if and only if the family of all the strict upper sections of the partial order is nested.
Effects of Yeast Concentration and Total Soluble Solids on the Quality of Wine Produced from Pineapple
Authors: Udeagha E. C. , Ishiwu C. N. , Obiora C. U. , Iwouno J. O. 
Published: October 2020

This research was carried out to determine the effects of yeast concentration and total soluble solids on the quality of wine produced from pineapple. The experiment was a Response Surface Methodology in the form of Rotatable Central Composite Design (RCCD). Ripe pineapple fruit (Ananas comosus) was processed using pressure extraction to obtain the juice. The juice was divided into thirteen (13) portions. Each portion’s total soluble solids was adjusted using sugar syrup and then pitched with specified yeast concentration. All the thirteen (13) samples were fermented for 168 h at 25±3 °C and aged for seven weeks. The wine was analyzed for pH, titratable acidity, ash content, final total soluble solids and alcohol content using standard methods. The sensory attributes (colour, aroma, taste, mouth-feel, texture and general acceptability) of the wines were analyzed by a twenty-five member panelist using 9-point hedonic scale. The results of the physico-chemical analysis of the pineapple wines showed that pH , titratable acidity (tartaric acid) content, alcohol and final total soluble solids ranged from 3.58 – 4.58, 0.33 – 0.59 %, 4.33 – 10.66 %v/v, 3.35 – 5.65 °Brix respectively. The ash content ranged from 0.20 – 0.50 %. The mean sensory scores for colour, taste, aroma, texture, mouth-feel and general acceptance ranged from 3.28 – 7.96, 4.08 – 6.68, 4.04 – 5.96, 4.16 – 5.32, 4.00 – 5.84 and 4.04 – 6.72 respectively. The mouthfeel of the pineapple wine samples did not differ significantly (P ≥ .05). Taste and alcohol exhibited significant model (P < .05), and were fitted into regression models. Pineapple has been found suitable for wine production. Using Saccharomyces cerevisiae var cerevisiae concentration of 6 %v/v and total soluble solids of 25 °Brix is suitable for production of pineapple wine and should be adopted.
Social and Economic Effect of Comprehensive Prevention of Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders in Children: A Review
Authors: Marianian Anait Yuryevna , Molchanova Elena Vladimirovna 
Published: October 2020

Introduction: Maternal alcohol consumption during pregnancy and its effects on the developing fetus are a serious global healthcare issue. The damage caused by alcohol goes far beyond mother’s health and spreads to the child’s physical and mental health.
Aim of Review: Analysis of existing approaches in organizing the necessary rehabilitation programs and preventing the consequences of drinking alcohol during pregnancy, assessing the potential socio-economic effect of organizing comprehensive prevention of fetal alcohol syndrome (FAS) and fetal-alcohol spectrum of disorders (FASD).
Materials and Methods: Children with FAS and influence of consequences of FAS/FASD on the nation’s material well-being conducted in Russia and abroad were analyzed by studying various published literature. Necessary rehabilitation measures for children with FAS/FASD were identified; analyzed international studies on the economic implications of the FAS/FASD; economic costs for medical and correctional services for children with FAS/FASD in Russia were assessed.
Results: This review found that the Not all children with FAS/FASD are mentally retarded, they have behavioral disorders and the development of the emotional-volitional sphere is significantly behind the age norms. So, at 10-12 years of age, these children are still not contractual and cannot remain without adult supervision even for several hours. They require ongoing parental or tutor support. The range of disorders in fetal alcohol syndrome is very diverse, therefore, each child requires an individual approach in the formation of a rehabilitation program, which significantly increases costs in general and requires the involvement of highly qualified specialists.
Conclusion: There is a need for additional economic calculations to scale up a comprehensive prevention program throughout the country. It is also important to note that the implementation of preventive measures does not eliminate the need for organizing assistance programs for families raising children with FAS/FASD.
Distribution of COVID-19 by Sex and Age Groups and Its Association with Travel and Contact History: An Overview of Early Epidemic
Authors: Khan Hamzullah , Khan Zahid , Afridi Saadullah , Bari Fazli 
Published: October 2020

Objectives: To determine the frequency of COVID-19 and its association with age, gender, travel and exposure.
Methods: This cross-sectional study was conducted in COVID-19 clinic, Qazi Hussain Ahmed Medical Complex, Nowshera, from February 2020 to April 2020. A total of 260 suspects were included under strict criteria. Patients received in general OPD and emergencies were excluded. Data was entered in a format in SPSS version 25 for analysis and reporting. Descriptive, inferential and correlation statistics were used.
Results: Out of a total 260 of suspects/patients, 66(25.4%) females and 194(74.6%) were males. The nasopharyngeal swabs of 63(24.23%) cases were sent for viral detection selected for PCR testing on the bases of a scoring system. Out of 63 cases 18(6.92%) were COVID-19 positive, 32(12.30%) negative and results of 12(4.61%) were still awaited. The estimated relative risk in male gender was rr=1.08, 95%CI, 0.77-1.55 and in age group>60 years was rr=2.27, 95%CI, 1.35-5.14. There was a positive statistically significant correlation of disease in patients with contact and travel history (p=0.05, rho=0.12; p=0.001, rho=0.34), respectively.
Conclusion: The results suggest that the age>50 years has higher susceptibility for COVID-19. Similarly, infectivity with 2019-nCoV has a statistically significant correlation with travel history, contact history and age.
Simple phantom fabrication for MRI‐based HDR brachytherapy applicator commissioning
Authors: Fagerstrom Jessica M. , Kaur Sukhjit 
Published: October 2020

AbstractA new high dose rate (HDR) brachytherapy program was initiated in a community hospital setting, with the goal of using magnetic resonance (MR) images with the implant in place during the planning process. Physics acceptance testing and commissioning was completed for key program components, including multiple applicators. To image new applicators for MRI‐based planning prior to use with patients, agar gel doped with copper sulfate was created using simple, MR‐safe household materials as a practical and inexpensive alternative to custom‐machined precision phantoms. Applicators in‐phantom were scanned in a 1.5 T MRI scanner using the same sequences developed for the brachytherapy program, then rigidly registered to high‐resolution computed tomography (CT) images to assess distortion, artifact, and geometric displacement. To date, Varian tandem and ring sets, segmented cylinders, cervical probes, endometrial applicators; and third‐party plastic needles, tandems, and vaginal guides have been imaged in phantom and are available for use clinically.
Frequent neurologic manifestations and encephalopathy‐associated morbidity in Covid‐19 patients
Authors: Liotta Eric M. , Batra Ayush , Clark Jeffrey R. , Shlobin Nathan A. , Hoffman Steven C. , Orban Zachary S. , Koralnik Igor J. 
Published: October 2020

AbstractObjectiveCovid‐19 can involve multiple organs including the nervous system. We sought to characterize the neurologic manifestations, their risk factors, and associated outcomes in hospitalized patients with Covid‐19.MethodsWe examined neurologic manifestations in 509 consecutive patients admitted with confirmed Covid‐19 within a hospital network in Chicago, Illinois. We compared the severity of Covid‐19 and outcomes in patients with and without neurologic manifestations. We also identified independent predictors of any neurologic manifestations, encephalopathy, and functional outcome using binary logistic regression.ResultsNeurologic manifestations were present at Covid‐19 onset in 215 (42.2%), at hospitalization in 319 (62.7%), and at any time during the disease course in 419 patients (82.3%). The most frequent neurologic manifestations were myalgias (44.8%), headaches (37.7%), encephalopathy (31.8%), dizziness (29.7%), dysgeusia (15.9%), and anosmia (11.4%). Strokes, movement disorders, motor and sensory deficits, ataxia, and seizures were uncommon (0.2 to 1.4% of patients each). Severe respiratory disease requiring mechanical ventilation occurred in 134 patients (26.3%). Independent risk factors for developing any neurologic manifestation were severe Covid‐19 (OR 4.02; 95% CI 2.04–8.89; P < 0.001) and younger age (OR 0.982; 95% CI 0.968–0.996; P = 0.014). Of all patients, 362 (71.1%) had a favorable functional outcome at discharge (modified Rankin Scale 0–2). However, encephalopathy was independently associated with worse functional outcome (OR 0.22; 95% CI 0.11–0.42; P < 0.001) and higher mortality within 30 days of hospitalization (35 [21.7%] vs. 11 [3.2%] patients; P < 0.001).InterpretationNeurologic manifestations occur in most hospitalized Covid‐19 patients. Encephalopathy was associated with increased morbidity and mortality, independent of respiratory disease severity.
Bioimprint Mediated Label‐Free Isolation of Pancreatic Tumor Cells from a Healthy Peripheral Blood Cell Population
Authors: Pelle Marie , Das Anupam A. K. , Madden Leigh A. , Paunov Vesselin N. 
Published: October 2020

AbstractNew techniques are required for earlier diagnosis and response to treatment of pancreatic cancer. Here, a label‐free approach is reported in which circulating pancreatic tumor cells are isolated from healthy peripheral blood cells via cell bioimprinting technology. The method involves pre‐fabrication of pancreatic cell layers and sequential casting of cell surfaces with a series of custom‐made resins to produce negative cell imprints. The imprint is functionalized with a combination of polymers to engineer weak attraction to the cells which is further amplified by the increased area of contact with the matching cells. A flow‐through bioimprint chip is designed and tested for selectivity toward two pancreatic tumor cell lines, ASPC‐1 and Mia‐PaCa‐2. Healthy human peripheral blood mononuclear cells (PBMCs) are spiked with pancreatic tumor cells at various concentrations. Bioimprints are designed for preferential retention of the matching pancreatic tumor cells and with respect to PBMCs. Tumor bioimprints are capable of capturing and concentrating pancreatic tumor cells from a mixed cell population with increased retention observed with the number of seedings. ASPC‐1 bioimprints preferentially retain both types of pancreatic tumor cells. This technology could be relevant for the collection and interrogation of liquid biopsies, early detection, and relapse monitoring of pancreatic cancer patients.
Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells
Authors: Amorim Sara , Soares da Costa Diana , Pashkuleva Iva , Reis Celso A. , Reis Rui L. , Pires Ricardo A. 
Published: October 2020

AbstractThe overproduction and deposition of hyaluronic acid (HA) of different sizes in the tumor microenvironment is associated with cancer metastasis. Here, the development of layer‐by‐layer (LbL) constructs containing HA of different molecular weights (i.e., 5.6, 618, and 1450 kDa) that mimic the HA‐rich cancer extracellular matrix is described to study the effect of the HA's size on the behavior of gastric cancer cells (AGS). The results demonstrate that LbL constructs with short HA, i.e., 5.6 kDa, activate the cytoskeleton rearrangement leading to the “hummingbird” morphology, promote high cellular motility, and activate signaling pathways with increased expression of p‐ERK1/2 and p‐AKT. In addition, it is demonstrated that this malignant transformation involves an active participation of the HA coreceptor RHAMM in AGS cells.
Tuning Fermi Levels in Intrinsic Antiferromagnetic Topological Insulators MnBi2Te4 and MnBi4Te7 by Defect Engineering and Chemical Doping
Authors: Du Mao‐Hua , Yan Jiaqiang , Cooper Valentino R. , Eisenbach Markus 
Published: October 2020

AbstractMnBi2Te4 and MnBi4Te7 are intrinsic antiferromagnetic topological insulators, offering a promising materials platform for realizing exotic topological quantum states. However, high densities of intrinsic defects in these materials not only cause bulk metallic conductivity, preventing the measurement of quantum transport in surface states, but may also affect magnetism and topological properties. In this paper, systematic density functional theory calculations reveal specific material chemistry and growth conditions that determine the defect formation and dopant incorporation in MnBi2Te4 and MnBi4Te7. The large strain induced by the internal heterostructure promotes the formation of large‐size‐mismatched antisite defects and substitutional dopants. The results here show that the abundance of antisite defects is responsible for the observed n‐type metallic conductivity. A Te‐rich growth condition is predicted to reduce the bulk free electron density, which is confirmed by experimental synthesis and transport measurements in MnBi2Te4. Furthermore, Na doping is proposed to be an effective acceptor dopant to pin the Fermi level within the bulk band gap to enable the observation of surface quantum transport. The defect engineering and doping strategies proposed here should stimulate further studies for improving synthesis and for manipulating magnetic and topological properties in MnBi2Te4, MnBi4Te7, and related magnetic topological insulators.
How Much Physical Guidance is Needed to Orient Growing Axons in 3D Hydrogels?
Authors: Rose Jonas C. , Gehlen David B. , Omidinia‐Anarkoli Abdolrahman , Fölster Maaike , Haraszti Tamás , Jaekel Esther E. , De Laporte Laura 
Published: October 2020

AbstractDirecting cells is essential to organize multi‐cellular organisms that are built up from subunits executing specific tasks. This guidance requires a precisely controlled symphony of biochemical, mechanical, and structural signals. While many guiding mechanisms focus on 2D structural patterns or 3D biochemical gradients, injectable material platforms that elucidate how cellular processes are triggered by defined 3D physical guiding cues are still lacking but crucial for the repair of soft tissues. Herein, a recently developed anisotropic injectable hybrid hydrogel (Anisogel) contains rod‐shaped microgels that orient in situ by a magnetic field and has propelled studying 3D cell guidance. Here, the Anisogel is used to investigate the dependence of axonal guidance on microgel dimensions, aspect ratio, and distance. While large microgels result in high material anisotropy, they significantly reduce neurite outgrowth and thus the guidance efficiency. Narrow and long microgels enable strong axonal guidance with maximal outgrowth including cell sensing over distances of tens of micrometers in 3D. Moreover, nerve cells decide to orient inside the Anisogel within the first three days, followed by strengthening of the alignment, which goes along with oriented fibronectin deposition. These findings demonstrate the potential of the Anisogel to tune structural and mechanical parameters for specific applications.