bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacologic strategies to prevent hemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy
Authors: Yoon Sang Won , Kang Hyun , Choi Geun Joo 
Published: December 2019

Abstract

Background:
Hypertensive disorders of pregnancy are major health issues affecting mothers and infants. General anesthesia is inevitable for certain mothers with these conditions and they may exhibit pronounced hemodynamic instability, especially during induction and airway manipulation. The aims of this study are to combine direct and indirect comparisons of the efficacies of different medications used in attenuating reflex hemodynamic responses and generate intervention ranking by network meta-analysis (NMA).

Methods:
A systematic and comprehensive search will be performed using MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar databases, beginning from their inceptions to November 2019. Only randomized clinical trials evaluating the efficacy and safety of pharmacologic interventions for preventing hemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy will be included. The primary endpoints will be maximal mean arterial pressure (MAP) and maximal heart rate after intubation. Maximal systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and maternal/fetal blood gas analysis, as well as safety issues, including Apgar score at 1 minute and 5 minutes after delivery, will be also assessed.
We will conduct both pairwise meta-analysis and network meta-analysis. We will use surface under the cumulative ranking curve (SUCRA) values and rankograms to present the hierarchy of pharmacologic interventions. A comparison-adjusted funnel plot will be used to assess the presence of small-study effects. The quality of the studies included will be assessed using the risk of bias tool 2.0. All statistical analyses will be performed using Stata SE, version 15.0 (StataCorp, College Station, TX).

Results:
The results of this systematic review and NMA will be published in a peer-reviewed journal.

Conclusion:
This NMA will enable us to determine the order of effectiveness and safety of pharmacological interventions used in attenuating hemodynamic responses for mothers with hypertensive disorders of pregnancy.

Trial registration number:
CRD42019136067.
Meta-analysis of influences of Biejiajian Pill combined with entecavir on serum liver fibrosis markers of compensatory period of hepatitis b cirrhosis
Authors: Zhang Tianyao , Yang Yu , Wang Baojia , Zheng Xiuli , Wang Long , Feng Xianrong , Li Guiyu , Shi Jinyu , Cao Ning 
Published: December 2019

Abstract

Background:
Chronic viral hepatitis b and its related complications have caused serious harm to human health and become a worldwide public health problem. Hepatitis b cirrhosis is one of the most common complications in Asia. Traditional Chinese medicine combined with antiviral therapy has become the first choice for clinical treatment of hepatitis b Cirrhosis. Biejia Pill is an effective prescription of traditional Chinese medicine in treating Compensatory period of cirrhosis, and there are more and more clinical reports about its validity in treating Compensatory period of cirrhosis. Therefore, we designed this study protocol to evaluate the adjuvant role of Biejia Pill in the treatment of Compensatory period of cirrhosis.

Method:
Electronic Databases, PubMed, EMBASE database, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang, Chinese Scientific Journals Database (VIP) and China Biology Medicine disc, (CBM), will be systematically searched from inception to July 2019. Randomized controlled trials (RCTs) on Biejiajian Pill combined with Entecavir and Entecavir alone against Compensatory period of hepatitis b cirrhosis will be included; inclusion and exclusion criteria will be used to screen the trials. liver fibrosis biomarkers including ECM or its metabolites (serum hyaluronic acid (HA), laminin (LN), procollagen type III (PC-III), and type IV collagen (IV-C)) will be measured as primary outcomes. Liver function, including alanine aminotransferase (ALT) and aspartarte aminotransferase (AST), and improvement of related clinical symptoms will be measured as secondary outcomes. RevMan5 software will be used for literature quality evaluation and data synthesis and analysis.

Result:
To evaluate the efficacy and safety of Biejiajian Pill in combination therapy by observing the outcomes of serum liver fibrosis markers, adverse reactions and liver function.

Conclusion:
This study protocol will be used to evaluate the efficacy and safety of Biejia Pill in combination with entecavir in the treatment of Compensatory period of hepatitis b cirrhosis, as well as the adjuvant treatment of Biejia Pill in combination.
PROSPERO registration number: CRD42019135402
Chart review of patients receiving valsartan–amlodipine single-pill combination versus valsartan and amlodipine combination for blood pressure goal achievement and effects on the Hamilton anxiety rating/Hamilton depression rating scales
Authors: Yin Gang , Li Yuefan , Xu Wenjie , Han Na 
Published: December 2019

Abstract
This study aimed to compare the Hamilton anxiety rating/Hamilton depression rating (HAMA/HAMD) scale scores and blood pressure (BP) goal achievement associated with the use of valsartan–amlodipine single-pill combinations (SPCs) versus valsartan and amlodipine combination in adult hypertensive patients.
A total of 476 hypertensive patients were randomly assigned into the SPC (valsartan–amlodipine) and control (valsartan and amlodipine combination) groups. All patients had an uncontrolled BP (160–179/100–109 mm Hg). BP goal was <140/90 mm Hg. Cox proportional hazards regression analysis was used to analyze the likelihood of HAMA/HAMD scales, SPCs, control group, and daily dosage number. Kaplan–Meier analysis was used to estimate the rates of BP goal achievement over time among the 2 groups.
A total of 476 patients were included in the study, and 439 patients completed the follow-up and received the index drug therapy. There was a significant difference in BP between the 2 groups on days 28, 42, and 56. Patients who received SPCs had a significantly higher rate of BP goal achievement over time (P = .000). The average HAMD scores in the SPC and control groups were 5.54 and 5.49 and 6.06 and 6.21 on days 28 and 56, respectively. The average HAMA scores in the SPC and control groups were 7.41 and 7.13 and 7.90 and 8.01 on days 28 and 56, respectively. The means of HAMD and HAMA scores were 5.826 and 7.614, respectively. The higher the HAMA/HAMD scores, the lower was the BP goal achievement. The number of drugs taken by the patients was associated with the HAMA and HAMD scores. There was no significant difference between HAMA scores of patients taking 1 tablet daily (7.22 ± 1.885) and those taking two-tablets daily (7.38 ± 1.953) (P = .408). However, when these scores were compared to those of patients taking 4 tablets daily (8.08 ± 2.285), a significant difference was observed (P = .000, P = .000).
Hypertensive patients treated with valsartan–amlodipine SPCs were significantly more likely to achieve BP goal and have lesser HAMA/HAMD scores compared to patients treated with valsartan and amlodipine combination.
National physician survey on glycemic goals and medical decision making for patients with type 2 diabetes
Authors: Laiteerapong Neda , Ham Sandra A. , Nathan Aviva G. , Sargis Robert M. , Quinn Michael T. , Huang Elbert S. 
Published: December 2019

Abstract
To describe how patient characteristics influence physician decision-making about glycemic goals for Type 2 diabetes.
2016 survey of 357 US physicians. The survey included two vignettes, representing a healthy patient and an unhealthy patient, adapted from a past survey of international experts and a factorial design vignette that varied age, heart disease history, and hypoglycemia history. Survey results were weighted to provide national estimates.
Over half (57.6%) of physicians recommended a goal HbA1c <7.0% for most of their patients. For the healthy patient vignette, physicians recommended a goal similar to that of international experts (<6.66% (95% Confidence Interval (CI), 6.61–6.71%) vs <6.5% (Interquartile range (IQR), 6.5–6.8%)). For the unhealthy patient, physicians recommended a lower goal than international experts (<7.38% (CI, 7.30–7.46) vs <8.0% (IQR, 7.5–8.0%)). In the factorial vignette, physicians varied HbA1c goals by 0.35%, 0.06%, and 0.28% based on age, heart disease history, and hypoglycemia risk, respectively. The goal HbA1c range between the 55-year-old with no heart disease or hypoglycemic events and the 75-year-old with heart disease and hypoglycemic events was 0.65%.
Despite guidelines that recommend HbA1c goals ranging from <6.5% to <8.5%, US physicians seem to be anchored on HbA1c goals around <7.0%.
Characteristic Radiological Features of Retrospectively Diagnosed Pancreatic Cancers
Authors: Fukushima Daizo , Nishino Noriyuki , Hamada Koichi , Horikawa Yoshinori , Shiwa Yoshiki , Nishida Shinya , Koyanagi Ryota , Abe Tsuyoshi , Suzuki Nobuyasu , Takano Yoshinao , Teranishi Yasushi , Munechika Hirotsugu , Miura Yoshihiro , Nakasato Tatsuhiko , Sakuma Hideo 
Published: December 2019

Objectives
The aim of this study was to assess the characteristic radiological features of early-stage pancreatic cancer (PC).

Methods
Between 2009 and 2016, 510 PC patients were selected from our hospital cancer registry database based on International Classification of Diseases for Oncology-3 (C25). Among them, 64 patients (42 males and 22 females; median age, 74 [range, 59–91]) had received repeated abdominal radiological examinations before their diagnosis of PC and were retrospectively investigated for specific radiological findings. The subjects underwent the following imaging examinations: computed tomography, magnetic resonance imaging, and fluoroglucose–positron emission tomography.

Results
Characteristic radiological features before diagnosis of PC were classified into the following 9 features: pancreatic duct ectasia (n = 16), focal low-density area (n = 15), change of cyst size (n = 8), localized tissue atrophy (n = 7), distal atrophy (n = 4), mass in pancreatic lipomatosis tissue (n = 2), mass concomitant with the already known cyst (n = 2), protrusion (n = 1), and parenchymal disproportion (n = 1). Fifty-three cases (84%) had more than one characteristic radiological feature before diagnosis of PC, and their median observation period until diagnosis was 24 (range, 1–120) months.

Conclusions
The 9 characteristic radiological features provide an opportunity to diagnose PC at an early stage.
Timely Reduction of Triglyceride Levels Is Associated With Decreased Persistent Organ Failure in Hypertriglyceridemic Pancreatitis
Authors: Lu Zhihua , Li Man , Guo Feng , Zhang Ge , Song Shuping , Liu Nan , Wang Donghai 
Published: December 2019

Objectives
The aim of the study was to examine the relationship between the reduction of serum triglycerides (TGs) and the severity of disease in patients with hypertriglyceridemic pancreatitis (HTGP).

Methods
A retrospective study was conducted among patients with HTGP. Serum TGs measured on admission (TG0), 24 hours after admission (TG24), and 48 hours after admission (TG48) were compared between patients with and without persistent organ failure (POF). Multivariable analysis determined whether elevated TG levels were independently associated with POF.

Results
A total of 242 patients were included, of which 62 patients (25.6%) developed POF. Patients who developed POF had higher TG levels of TG0, TG24, and TG48 than those without POF (all P < 0.05). Patients with earlier TG levels of less than 5.65 mmol/L were proportionally less likely to develop POF (P
trend = 0.002). On multivariate analysis, TG48 of 5.65 mmol/L or more was independently associated with POF (odds ratio, 3.316; 95% confidence interval, 1.256–8.755; P = 0.016).

Conclusions
Timely reduction of serum TGs during the early phase of HTGP is proportionally associated with decreased development of POF. Serum TG levels by 48 hours of admission correlate independently with POF.
Assessing Patient Satisfaction and Experience With an Electronic Referral Process
Authors: Mohammed Heba Tallah , Huebner Lori-Anne 
Published: December 2019

Background and Objectives:
Our study aimed to identify patients' perception of an eReferral process and e-mail notification system.

Methods:
Patients within the Waterloo Wellington Local Health Integration Network who registered their e-mail address with physicians who adopted the eReferral system, and therefore received e-mail notifications of their booked appointment, were invited to complete an online satisfaction survey. This patient experience survey is an ongoing online link embedded within the confirmation e-mail of the booked appointment. The survey is hosted on the eReferral solution platform and has been operational since November 2017. The survey consists of 8 questions with 3 main categories to assess patients' opinion of their experience of the referral process and notification system using a 5-point Likert scale and open-ended questions.

Results:
A total of 545 patients have completed the patient satisfaction survey within this reporting period with a response rate of 15%. In general, 94% of patients agreed that receiving a confirmation e-mail of their booked appointment had improved their experience with the referral process. The majority (94%) agreed that the eReferral process was easy to follow, and 83% agreed that they were able to get the care they needed within a reasonable time. Compared with their past referral experiences, 80% of patients felt more informed throughout this electronic referral process. Using binominal logistic regression, participants whose preferences were considered had 8.06 times higher odds to exhibit satisfaction with the referral process than those who did not. Patients' qualitative responses identified the eReferral process as being quick, efficient, and resulting in a sense of being in control of their own health care. There are some limitations to the system felt by some of the patients who responded to the open-ended questions of the survey. Patients identified the need to add a complementary structure to the notification design consisting of multiple dates and times with a chance to pick the appointment that suits patients best instead of being restricted to only 1 appointment date. A few patients thought that the heading of the e-mail notification system should be more distinguishable for easier tracking. Furthermore, some patients felt the need to add some notes to the initial e-mail advising patients of the next steps throughout their referral process.

Conclusion:
eReferral has improved patients' experience with the referral process. Our findings in this study would support the solution vendor in its efforts to refine and enhance active communication channels with patients for sustainable health care that meets patients' expectations and needs.
Short Face Dentofacial Deformities: Changes in Social Perceptions, Facial Esthetics, and Occlusion After Bimaxillary and Chin Orthognathic Correction
Authors: Posnick Jeffrey C. , Ogunsanya Oluremi , Singh Neeru , Kinard Brian E. 
Published: December 2019

Abstract
The purpose of this study was to document changes in social perceptions and facial esthetics, and document occlusion outcomes in a series of short face (SF) dentofacial deformity (DFD) subjects. The investigators hypothesized that subjects would achieve positive change in social perceptions and facial esthetics, and maintain a long-term corrected occlusion after undergoing bimaxillary and chin osteotomies.
A retrospective cohort study was implemented. Photographic records and occlusion parameters were studied preoperatively and >2 years after surgery. The first outcome variable was social perceptions of SF subjects, judged by laypersons. The second outcome variable was facial esthetics, judged by professionals. The third outcome variable was occlusion maintained long-term.
Fifteen subjects met inclusion criteria. Mean age at operation was 33 years. Consistent facial contour deformities at presentation included deficient maxillary dental show and downturned oral commissures. As a group, there was improvement (P < 0.05) in 11 of 12 social perceptions, judged by laypersons, all subjects achieved correction of the facial esthetic parameters studied by professionals, and all subjects maintained a favorable occlusion long-term.
In SF DFD subjects, bimaxillary and chin surgery proved effective to improve social perceptions, to correct facial contour deformities, and in achieving a long-term corrected occlusion.
Drug-induced decreased urine output predicts PDA closure in preterm neonates
Authors: Goel Malika , Dutta Sourabh , Saini Shiv Sajan , Sundaram Venkataseshan 
Published: December 2019

ABSTRACTObjectiveProstaglandin inhibitors (PGI) are used to treat patent ductus arteriosus (PDA) of prematurity. PGIs often cause decrease in urine output (UO), the mechanism of which is like that of PDA closure. We hypothesized that PGI-induced decrease in UO predicts PDA closure.DesignProspective, cohortSettingLevel III NICUMethodsWe prospectively enrolled 40 preterm neonates (≤34 weeks gestation) with clinical and/or echocardiographic hemodynamically significant PDA (hsPDA), being treated with Ibuprofen or Paracetamol. We measured UO, weight, total fluid intake (TFI) at baseline and daily until 72 h. We performed echocardiogram at baseline and daily until PDA closure or end of treatment. We compared “PDA-closed” and “PDA-open” groups for change in UO, weight and TFI from baseline.Results“PDA-closed” and “PDA-open” groups had 28 and 12 neonates respectively. Median (Q1, Q3) percent decrease in UO was greater in “PDA-closed” vs “PDA-open” group: from baseline to 0-24 h [-44.87% (−54.79%, +0.04%) vs −15.03% (−27.91%, +49.11%)]; to 24-48 hours [-40.85% (−52.81%, +14.45%) vs. −2.57% (−24.82%, +61.73%) and to 48-72 hours [-32.77% (−49.4%, +32.22%) vs. +20.74% (−6.88%, +98.39%). “PDA closed” group had significantly greater percent decrease in weight by 72-h. Mixed linear model showed that “group” and “time” were independently associated with UO; but “group*time” interaction and covariates (echocardiographic hsPDA, weight, gestation, postnatal age) were not. Decrease in UO of 27% and 17% by 24-48 h and 48-72 h respectively, best predicted PDA closure.ConclusionsTransient decrease in UO after treating hsPDA with a PGI may predict successful closure of PDA.
Gender score development in a retrospective approach in the Berlin Aging Study II
Authors: Nauman A. Tauseef , Behlouli Hassan , Alexander Nicholas , Kendel Friederike , Drewelies Johanna , Mantantzis Konstantinos , Berger Nora , Wagner Gert G. , Gerstorf Denis , Demuth Ilja , Pilote Louise , Regitz-Zagrosek Vera 
Published: December 2019

AbstractIn addition to biological sex, gender, the sociocultural dimension of being a woman or a man, plays a central role in health. However, there are so far no approaches to quantify gender in a retrospective manner in existing study datasets. We therefore aimed to develop a methodology that can be retrospectively applied to assess gender in existing cohorts. We used baseline data from the Berlin Aging Study II (BASE-II), obtained in 2009-2014 from 1869 participants aged 60 years and older. We identified 13 gender related variables and used them to construct a gender score (GS) by primary component and logistic regression analysis. Of these, 9 variables contributed to a gender score: chronic stress, marital status, risk taking behavior, agreeableness, neuroticism, extraversion, loneliness, conscientiousness, and education. GS differed significantly between females and males as defined by sex. Next, we calculated linear regressions to investigate associations between sex, GS, and selected biological and well-being variables. Sex, but not GS was significantly associated with LDL-C and TC. GS, but not sex, was significantly associated with cortisol levels, CES-depression, negative affect, life satisfaction. Thus, we were able to develop a GS in a retrospective manner from available study variables that characterized women and men in addition to biological sex. This approach will allow us to introduce the notion of gender retrospectively into a large number of studies.
Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction
Authors: Sgrignani Jacopo , Cecchinato Valentina , Fassi Enrico M.A. , D’Agostino Gianluca , Garofalo Maura , Danelon Gabriela , Grazioso Giovanni , Uguccioni Mariagrazia , Cavalli Andrea 
Published: December 2019

AbstractDuring inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. HMGB1 and the chemokine CXCL12, both released in the microenvironment, form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis, exacerbating the immune response. An excessive cell influx at the inflammatory site can be diminished by disrupting the heterocomplex.Here, we report the computationally driven identification of a novel peptide (HBP08), which binds HMGB1 with the highest affinity reported so far (Kdof 0.8 ± 0.1 μM), able to selectively inhibit the activity of the CXCL12/HMGB1 heterocomplex.The identification of this peptide represents an important step towards the development of innovative pharmacological tools for the treatment of severe chronic inflammatory conditions characterized by an uncontrolled immune response.
Cognitive computing on unstructured data for customer co-innovation
Authors: Chen Sixing , Kang Jun , Liu Suchi , Sun Yifan 
Published: December 2019

Purpose
This paper aims to build on the latest advances in cognitive computing techniques to systematically illustrate how unstructured data from users can offer significant value for co-innovation.

Design/methodology/approach
The paper adopts a general overview approach to understand how unstructured data from users can be analyzed with cognitive computing techniques for innovation. The paper links the computerized techniques with marketing innovation problems with an integrated framework using dynamic capabilities and complexity theory.

Findings
The paper identifies a suite of methodologies for facilitating company co-innovation via engaging with customers and external data with cognitive computing technologies. It helps to expand marketing researchers and practitioners’ understanding of using unstructured data.

Research limitations/implications
This paper provides a conceptual framework that divides co-innovation process into three stages, ideas generation, ideas integration and ideas evaluation, and maps cognitive computing methodologies and technologies to each stage. This paper makes the theoretical contributions by developing propositions from both customer and firm perspectives.

Practical implications
This paper can be used for companies to engage consumers and external data for co-innovation activities by strategically select appropriate cognitive computing techniques to analyze unstructured data for better insights.

Originality/value
Given the lack of systematic discussion regarding what is possible from using cognitive computing to analyze unstructured data for co-innovation. This paper makes first attempt to summarize how unstructured data can be analyzed with cognitive computing techniques. This paper also integrates complexity theory to the framework from a novel perspective.