bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPACT OF HEMOLYSIS DURING MICRO-AXIAL FLOW PUMP SUPPORT ON EARLY OUTCOMES AFTER DURABLE LVAD IMPLANTATION: INSIGHTS FROM AN INTERNATIONAL REGISTRY
Authors: Loforte A. , Spitaleri A. , Gallone G. , Lewin D. , Rojas Hernandez S. , Bernhardt A. , Billion M. , Meyer A. , Netuka I. , Kooij J. , Pieri M. , Szymanski M. , Moeller C. , Akhyari P. , Jawad K. , Krasivskyi I. , Schmack B. , Färber G. , Medina M. , Haneya A. , Zimpfer D. , Nersesian G. , Lanmüller P. , Monteleone G. , Oezkur M. , Djordjevic I. , Saeed D. , Boffini M. , Stein J. , Gustafsson F. , Scandroglio M. , Meyns B. , Hofmann S. , Belohlavek J. , Gummert J. , Potapov E. , Rinaldi M. 
Published: December 2024

Aim and Background:
The impact of hemolysis during micro-axial flow pump (mAFP, Impella, Abiomed) support on early outcomes after durable left ventricular assist device (d-LVAD) implantation is unknown.

Methods:
Among 341 patients undergoing d-LVAD implantation after mAFP support, between January 2017 and December 2022, at 19 international Institutions, 311 were retrospectively included (male gender 82.6%, median age 58 years, Impella 5.0/5.5 72.3%, HeartMate III 57.7%). The incidence and predictors of hemolysis, as well as its impact on early post-d-LVAD outcomes were assessed. The primary outcome was a composite of hemocompatibility-related adverse events (HRAEs: stroke, gastrointestinal bleeding, pump thrombosis).

Results:
Hemolysis occurred in 40.8% of the patients. Impella 2.5/CP vs. 5.0/5.5 was the single independent predictor of hemolysis (adj-HR 2.68, 95%CI 1.04-6.94, p=0.031). Post- d-LVAD HRAEs occurred more frequently among patients with hemolysis (31.9% vs. 20.6%, p=0.041), mainly driven by hemorrhagic stroke and gastro-intestinal bleeding. At multivariate analysis, hemolysis remained independently associated with HRAEs (adj-HR 1.62, 95%CI 1.02-2.58, p=0.041), together with higher body surface area (p<0.001) and female sex (p=0.004). Patients with hemolysis were more likely to need a temporary right ventricular assist device following d-LVAD implantation (28.3% vs. 16.8%, p=0.012) and to undergo early heart transplantation (17.4% vs. 8.6%, p=0.031), while no difference in mortality was observed (23.6% vs 21.2%, p=0.355).

Conclusions:
Among patients undergoing d-LVAD implantation with mAFP bridge, hemolysis during mAFP support is common, occurs more frequently among patients supported with Impella 2.5/CP, and is an independent predictor of post- d-LVAD early HRAEs, mainly driven by bleeding events
POST-IMPLANT TRANSCATHETER AORTIC PROSTHESIS DEFORMATION: TRICUSPID VERSUS BICUSPID VALVE.
Authors: Zaccone G. , Moscarelli M. , Pernice V. , Trizzino F. , Milo S. , Speziale G. , Fattouch K. 
Published: December 2024

Objective:
There is conflicting evidence supporting the widespread use of transcatheter aortic prostheses for bicuspid valves. In these patients, prosthesis deformation, also known as non- uniform expansion, may frequently occur. Little information is available regarding post- implant prosthesis behaviour in the context of native tricuspid versus bicuspid aortic valve stenosis, particularly following self-expandable valves.

Methods:
We analysed 100 consecutive post-implant multi detector computed tomography scans to assess prosthesis non-uniform expansion at six pre-specified valvular levels, and other specific parameters, including valvular and perivalvular thrombosis at six months follow-up. Echocardiographic prosthesis performance and clinical outcome was also evaluated.

Results:
Mean eccentricity was significantly higher in the bicuspid group (0.43 ± 0.09 vs 0.37± 0.08, p=0.005, bicuspid vs tricuspid); valvular and perivalvular thrombosis were also significantly more frequent in the bicuspid than in the tricuspid group (81% vs. 36.9%, p=0.031); there was no significant difference in terms of mean prosthetic gradient at follow-up between groups (7.31 ± 5.53 mmHg vs 7.09 ± 3.05 mmHg, p= 0.825); EOAi was also similar between bicuspid and tricuspid (1.08 ± 0.12 cm2 vs 1.03 ± 0.13 cm2, p=0.101), with no significant changes compared to discharge. However, the bicuspid valve was associated with a significantly higher risk of adverse events (HR:3.72, 95%CI: 1.07-13.4, p= 0.027).

Conclusions:
Higher levels of eccentricity, which indicates prosthesis deformation, is often detected in bicuspid valves. Although echocardiographic performance was not affected, this might have led to an increased incidence of thrombosis at valvular and perivalvular levels and worse outcomes
COMBINED ENDOSCOPIC VALVE SURGERY AND CORONARY ARTERY BYPASS VIA MINI-THORACOTOMY
Authors: Margari V. , Squiccimarro E. , Visicchio G. , Kounakis G. , Pascarella C. , Carbone C. , Paparella D. 
Published: December 2024

Background:
Consistent evidence favors of endoscopic valve surgery (eVS) exists. Yet, the adoption of minimally invasive coronary surgery (MICS) remains low, particularly for combined procedures. We aim to describe our experience with combined eVS and MICS.

Methods:
We reviewed patients who underwent eVS+MICS at Santa Maria Hospital, Bari, from 2021-2024. The primary outcome was follow-up mortality. Patients received MICS and either endoscopic mitral repair (eMVr) or aortic valve replacement (eAVR). After double- lumen endotracheal intubation, right internal jugular vein cannulation, right groin incision for echo-guided cannulation, cardiopulmonary bypass establishment, Chitwood clamp insertion at the second interspace (IS-2), eMVr was performed via right-MT above the nipple at IS-4 while eAVR via anterior MT at IS-3. MICS consisted of a left internal thoracic artery (LITA) to left anterior descending off-pump graft via an additional left-MT at IS-5 in eMVr cases, and a saphenous vein (SVG) to posterior descending artery (PDA) graft via the same right-MT, in eAVR cases.

Results:
Thirteen patients underwent eVS+MICS: age was 67±4 years, 8 were male, and EuroSCORE II was 2.6±1.1. Nine patients had eMVr: 6 posterior leaflet resections, and 4 neochordal repairs. All eMVr included ring annuloplasty; four had monopolar ablation and left atrial appendage closure. Four patients had eAVR with bioprosthesis and SVG-to-PDA. Mechanical ventilation averaged 4±2 hours, with ICU discharge after 2±1 days. All patients were discharged healthy, with no deaths at 2-year follow-up.

Conclusion:
Combined eVS+MICS is safe, with satisfactory outcomes. Minimally invasive techniques should be adopted in specialized centers, even in complex cases.
TAVI, VALVE IN MAC AND CLOSURE OF PARAVALVULAR LEAK IN AN INOPERABLE PATIENT
Authors: Di Carlo M. , Cavalli G. G. , Vallabini A. , Spatuzza P. , Braccio M. , Palladino M. , Gallo N. , Alemanni R. , Leone A. , Di Marco L. , Pacini D. , Cassese M. 
Published: December 2024

Particularity of the video:
Multivalvular disease (MVD) still represents a challenging scenario. The first-choice treatment is usually open surgery, given the possibility of simultaneously treating all the involved valves. Nonetheless, patients’ clinical conditions are getting far worse, dramatically increasing the surgical risk and operative mortality. Therefore, a transcatheter approach may represent a safe alternative, though considering the burden of a high technical complexity.

Brief description:
We report the case of a 76-year-old female affected by severe aortic and mitral valve stenosis, presenting with acute heart failure (NYHA IV). Surgery was denied due to chronic myeloid leukemia, determining severe pancytopenia (platelet count 12000/mm3) and unfavorable anatomical characteristics, related to the extremely calcified mitral valve ring (MAC). A transcatheter approach was chosen, performing in a single-step procedure a TAVI, a TVMI-in- MAC and a subsequent paravalvular leak closure. The patient was eventually discharged and in good clinical conditions at 1 month follow-up.
HEART TRANSPLANTATION IN ADULT WITH CONGENITAL HEART DEFECTS: HOW FAR IS TOO FAR IN WAITING LIST? SIEVING RESULTS THROUGH A RISK SCORE
Authors: Berardi M. , careddu L. , orioli V. , mangerini V. F. , petridis F. D. , ragni L. , assenza G. E. , agulli M. , gargiulo D. G. , angeli E. 
Published: December 2024

Background:
Adult with congenital heart defects (ACHD) constitute a heterogeneous and expanding group of patients. ACHD are characterized by complex cardiac anatomical features, precarious hemodynamic stability and associated multiorgan dysfunction, with higher risk for advanced heart failure requiring orthotopic heart transplantation (OHT). To stratify this risk, Seese et al. proposed an ACHD-OHT-Risk Score for 1-year mortality including age, comorbidities and laboratory values. This study evaluated early and long-term survival of ACHD underwent OHT in our unit and the adherence of the ACHD-OHT-Risk Score for our population.

Methods:
ACHD (age>16 years) underwent OHT between January 1997 and August 2024 were analyzed in the study. Kaplan-Meier analysis was performed to report the early and long-term survival. In addition, population was divided in two groups according to the ACHD-OHT-Risk Score: Low-risk (<2 points)-High-risk(≥2points). Groups’ survival at 1year was compared.

Results:
From 1997 to 2024, 33 ACHD underwent OHT. Mean age at transplant was 33,32 ± 12,60 years. Parameters used to determine the risk score are reported in fig.1. The overall survival at 1, 10,20 years was 84.8%, 77.7% and 64.8% respectively. Low-risk group included 13 patients (39,4%), High-risk group 20 patients (60,6%). One-year survival in low-risk group at 1,6,12 months was 100%,92%,92%, while in high risk group 95%,80% and 80%, respectively (log- rank=0.33).

Conclusion:
OHT in ACHD remains challenging and affected by high risk mortality in the first year of follow-up. The ACHD-OHT-Risk Score derived some risk factors of early mortality and could suggest a more aggressive approach to waiting list enrolment and progression to achieve OHT in optimal multiorgan conditions.
Topical Helichrysum italicum Essential Oil-Based Ointment Hastens Excisional Wound Healing by Alleviating Inflammation and Oxidative Stress in Diabetic Rats
Authors: Andjic Marijana , Kocovic Aleksandar , Vucicevic Ksenija , Jakovljevic Vladimir , Simanic Igor , Vukasinovic Vesic Milica , Bradic Jovana 
Published: December 2024

Abstract
This study aimed to develop novel topical semi-solid formulation based on Helichrysum italicum (H. italicum) essential oil and to assess its wound-healing capacity through macroscopic and biochemical examination of markers of inflammation and oxidative stress. Methods: The wound-healing effect was evaluated on an excision wound model. The study was carried out on male Wistar albino rats with induced diabetes type 1. Diabetic rats were randomly divided into four groups: control (CTRL), 1% silver sulfadiazine (SSD), ointment base (OINT), and HIEO OINT (H. italicum essential oil-based ointment). The investigated formulations were applied once daily, for three weeks. The formulation containing H. italicum essential oil has shown no changes in color, smell, consistency, or homogeneity during the storage period at room temperature for six months. Three-week administration of HIEO ointment led to a significant reduction in wound size and the percentage of wound contraction was the highest in HIOE point group. A significant increase in wound contraction percentage was observed from day 7. The treatment with HIEO ointment significantly reduced tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and enhanced IL-10 levels. Additionally, a three-week administration of HIEO ointment elevated antioxidative enzymes detected in wound tissue. Our findings showed that topical application of HIEO ointment showed immense potential in augmenting skin wound regeneration in diabetes rats by upregulating the antioxidant status as well as modulating cytokines.
Diabetic Kidney Disease Position Paper of the Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO), Macedonian Society of Cardiology (MSC), and Scientific Association of Endocrinologists and Diabetologists of Macedonia (SAEDM)
Authors: Spasovski Goce , Markovska Zaklina Sterjova , Gjorgjievski Nikola , Poposka Lidija , Kostov Jorgo , Bosevski Marijan , Ahmeti Irfan , Jovanovska-Mishevska Sasha , Milenkovic Tatjana 
Published: December 2024

Abstract
Diabetic kidney disease (DKD) is a significant and growing global health concern, affecting a substantial proportion of individuals with diabetes mellitus. This position paper of Scientific societies of endocrinologists, nephrologists and cardiologists has been consensually brought at a couple of mutual meetings, aiming to synthesize current knowledge on screening, diagnosis and staging of DKD, emphasizing the need for an early detection and intervention in order to prevent progression to end-stage renal disease (ESRD). The role of glycemic control, blood pressure management, lipid management and the use of reno and cardioprotective agents, including angiotensin-converting enzyme inhibitors, sodium-glucose co-transporter 2 inhibitors and non-steroidal mineralocorticisteroid receptor antagonist has been entirely considered. Furthermore, we highlight the importance of a multidisciplinary approach in the care of patients with DKD, integrating lifestyle modifications and patient education into the clinical practice. This paper advocates for the implementation of standardized screening protocols and the development of personalized treatment strategies to optimize patient outcomes. By addressing the complexities of DKD, we aim to provide a comprehensive framework for healthcare professionals to enhance the quality of care for individuals at risk of or living with this condition.
Ansiedad, depresión y abuso de sustancias en estudiantes: cambios durante la pandemia de covid-19
Authors: Manríquez-Calderón Sarahi del Carmen , Villuendas-González Erwin Rogelio , Padrós-Blázquez Ferrán , Gudayol-Ferré Esteban 
Published: December 2024

Desde los primeros meses de 2020, la pandemia por covid-19 llevó a muchos gobiernos a instrumentar medidas de aislamiento que afectaron negativamente la salud mental de las personas susceptibles. Además, diversos estudios muestran cambios en la prevalencia de problemas relacionados con la salud mental en poblaciones de distintas edades; no obstante, el efecto que se describe en la literatura muestra que hubo diferencias entre grupos etarios y poblaciones de distintas nacionalidades. Objetivo: Comparar los niveles de ansiedad, depresión y riesgo de abuso de sustancias en muestras de estudiantes universitarios mexicanos antes y durante la pandemia. Instrumentos: Inventario de Ansiedad de Beck, Inventario de Depresión Beck y Substance Abuse Screening Test. Método: Se compararon los datos de cuatro muestras de estudiantes universitarios, tres obtenidas antes de la pandemia (n = 1,709) y una durante misma (n = 180). Resultados: Al comparar esas muestras se halló una sustancial disminución en la prevalencia de niveles bajos o ausentes de ansiedad y depresión, así como un incremento en la prevalencia de los niveles moderados. Los niveles de ansiedad y depresión durante la pandemia fueron más elevados que antes de la pandemia. Discusión: No se encontraron diferencias en la prevalencia del riesgo de abuso de sustancias. Estos hallazgos caracterizan los cambios en la población estudiantil mexicana y muestran que no obstante las diferencias entre los países respecto a las medidas sociales asumidas ante la pandemia, los cambios en la salud mental revelan patrones similares.

Recibido: 03/03/2023Aceptado: 07/11/2023
Mapping on discourses on the relationships between gender, sexuality and demand for paid-sex in Spain
Authors: Gómez Gómez Francisco , Munuera Gómez Pilar , Martínez-López José Ángel , Carrión-López Antonia 
Published: December 2024

This article mapping the explores the relationship that emerges from social discourses between the social construction of gender, the social construction of affective-sexual relationships and the demand for paid sex of men who pay for sex in Murcia (Spain). The methodology has a qualitative approach, based in case studies, throught analysis of the social and individual discourses of participants (focus groups and in-depth interviews). Among the main conclusions is that the institution of prostitution reproduces a message of inequality between women and men although this is not always reproduced at the individual level at the time of exchanges between prostitutes and clients. More research is needed on the real situation of women in prostitution in order to address this phenomenon and, at the same time, to reduce gender inequality and protect the rights of women in prostitution.
ОСОБЕННОСТИ ШЕРИНГОВОЙ ЭКОНОМИКИ НА УКРАИНЕ
Authors: Швед В.В. , Яблочников С.Л. 
Published: December 2024

В статье рассматриваются вопросы, связанные с определением понятия «шеринговая экономика». Проанализирована сущность так называемой экономики шеринга, приведены основные принципы ее функционирования как разновидности поведенческой экономики. Сформулированы общие аспекты проникновения шеринговой экономики в повседневную жизнь общества, интенсивность развития и распространения шеринговых платформ в сети Интер- нет. Проанализированы основные модели шеринга, актуальные в современных условиях. Рассмотрены шеринговые платформы, функционирующие на Украине. Особое внимание уделено успешным примерам практической реализации экономики шеринга, которые поддерживаются государством. Изучены факторы, оказывающие существенное влияние на развитие шеринговой экономики страны.
The article examines the issues related to the definition of the concept of «sharing economy». The essence of the sharing economy is analyzed; the basic principles of functioning of the sharing economy as a kind of behavioral economics are given. The general aspects of penetration of the sharing economy into the everyday life of society, the intensity of development and distribution of the sharing platforms in the Internet are formulated. The main sharing models are analyzed. The sharing platforms in Ukraine are studied. Particular attention is paid to successful examples of implementation of the sharing economy, which are supported by the state. Factors influencing the country’s sharing economy were studied.
СОВРЕМЕННЫЕ ПРОБЛЕМЫ УСЫНОВЛЕНИЯ КАК ФОРМЫ УСТРОЙСТВА ДЕТЕЙ, ОСТАВШИХСЯ БЕЗ ПОПЕЧЕНИЯ РОДИТЕЛЕЙ
Authors: Менкеева Е.П. 
Published: December 2024

В статье доказывается, что усыновление ребенка является одной из самых обсуждаемых теоретических и практических проблем в семейном праве России. Из числа многочисленных научных определений усыновления, по мнению автора, наиболее приемлемой является позиция тех научных школ, которые обращают внимание на соотношение взаимных прав и обязанностей кровных родителей, усыновителей и детей, отмечая отсутствие их полной тождественности. Весьма важным является и тот факт, что усыновление регулируется нормами различной отраслевой принадлежности (и даже различными нормами материального и процессуального права), представляя собой комплексный межотраслевой институт. В связи с этим автор считает недопустимым отождествление процедур усыновления (его отмены) с отдельными гражданско-правовыми категориями.
The article proves that the adoption of a child is one of the most discussed theoretical and practical problems in the family law of Russia. Among the numerous scientific definitions of adoption, according to the author, the position of those scientific schools that pay attention to correlation of mutual rights and obligations of the blood parents, adoptive parents and children is the most acceptable one, noting the absence of their complete identity. Very important is the fact that adoption is regulated by the norms of different industry affiliation (and even by different norms of substantive and procedural law), representing a complex interdisciplinary institution. In this regard, the author considers it inadmissible to identify the adoption procedures (its abolition) with individual civil-law categories.
ПРЕДПОСЫЛКИ ОРГАНИЗАЦИИ СЛУЖБЫ КОНТРОЛЛИНГА НА ПРОМЫШЛЕННОМ ПРЕДПРИЯТИИ
Authors: Крумина К.В. , Полковникова С.Г. 
Published: December 2024

Статья носит практико-ориентированный характер. Изменение условий внешней среды создает необходимость изменения внутренней среды предприятия в части повышения гибкости и эффективности управления финансовыми ресурсами. В статье на примере ГК «Титан» описывается текущая структура управления финансово-экономической деятельностью во взаимосвязи с другими подразделениями, выявляются недостатки существующей системы, предлагается внедрение службы контроллинга. Это позволит повысить эффективность управления консолидированными де- нежными потоками, разработать методологию подготовки финансовой отчетности для всех компаний, входящих в ГК «Титан», предоставлять руководству предприятия более полную информацию для принятия управленческих решений.
The article is of a practice-oriented nature. Changing of the conditions of the external environment makes it necessary to change the internal environment of the enterprise in terms of increasing the flexibility and efficiency of financial resources management. On the example of GC «Titan», the article describes the current structure of management of financial and economic activities in conjunction with other units, identifies the shortcomings of the existing system, proposed introduction of controlling service. This will improve the management of consolidated cash flows, develop a methodology for preparation of financial statements for all companies within the Titan Group of Companies, provide the company’s management with more complete information for making managerial decisions.
ПРОБЛЕМЫ ФИНАНСИРОВАНИЯ НАУЧНЫХ ИССЛЕДОВАНИЙ В РОССИИ И АНАЛИЗ ЗАРУБЕЖНОГО ОПЫТА
Authors: Михеева А.С. , Лубсанова Н.Б. , Балдаева А.О. 
Published: December 2024

В статье анализируются современные проблемы финансирования научных исследований и разработок в Российской Федерации. Проведен сравнительный анализ расходов на науку в России в сопоставлении с зарубежными странами. Рассмотрены основные теоретические подходы к организации финансирования научных исследований. Выявлены основные проблемные точки: доминирование бюджетного финансирования научных исследований не только в деятельности государственных научных учреждений, но и в коммерческом секторе; недостаточное участие бизнеса в финансировании научных исследований и разработок; низкий уровень внедрения инноваций. На основе полученных результатов предложены меры по обеспечению условий развития инновационной деятельности.
The article analyzes modern problems of financing research and development in the Russian Federation. A comparative analysis of expenditures for science in Russia compared with foreign countries has been carried out. The main theoretical approaches to the arrangement of financing of scientific research are considered. The main problem points are identified: the domination of budgetary funding for research not only in the activities of state scientific institutions, but also in the commercial sector, inadequate participation of business in financing research and development, and the low level of innovation. On the basis of the results obtained, measures were proposed to ensure the conditions for development of innovative activity.