bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tools for Assessment of Country Preparedness for Public Health Emergencies: A Critical Review
Authors: Haeberer Mariana , Tsolova Svetla , Riley Paul , Cano-Portero Rosa , Rexroth Ute , Ciotti Massimo , Fraser Graham 
Published: May 2020

ABSTRACTRecent international communicable disease crises have highlighted the need for countries to assure their preparedness to respond effectively to public health emergencies. The objective of this study was to critically review existing tools to support a country’s assessment of its health emergency preparedness. We developed a framework to analyze the expected effectiveness and utility of these tools. Through mixed search strategies, we identified 12 tools with relevance to public health emergencies. There was considerable consensus concerning the critical preparedness system elements to be assessed, although their relative emphasis and means of assessment and measurement varied considerably. Several tools identified appeared to have reporting requirements as their primary aim, rather than primary utility for system self-assessment of the countries and states using the tool. Few tools attempted to give an account of their underlying evidence base. Only some tools were available in a user-friendly electronic modality or included quantitative measures to support the monitoring of system preparedness over time. We conclude there is still a need for improvement in tools available for assessment of country preparedness for public health emergencies, and for applied research to increase identification of system measures that are valid indicators of system response capability.
Accounting for phylogenetic relatedness in cross-species analyses of telomere shortening rates
Authors: Pepke Michael Le , Eisenberg Dan T.A. 
Published: May 2020

AbstractTelomeres are repeating DNA sequences found on the ends of chromosomes, which shorten with age and are implicated in senescence. Cross-species analyses of telomere shortening rates (TSR) and telomere lengths are important for understanding mechanisms underlying senescence, lifespan and life-history strategies of different species. Whittemore et al. (2019) generated a new dataset on variation in TSR, lifespan and body mass. In phylogenetically uncorrected analyses they found that TSR negatively correlates with lifespan. We re-ran analyses of their dataset using appropriate phylogenetic corrections. We found a strong phylogenetic signal in the association between TSR and body mass. We were able to corroborate Whittemore et al.’s major findings, including while correcting for body mass in a multivariate analysis. Since laboratory mice have different telomere lengths and potentially different telomere dynamics than wild mice, we removed mice from the analysis, which attenuates most associations.
HUMAN RESPONSES TO CLIMATE CHANGE IN THE LATE PREHISTORIC WESTERN LOESS PLATEAU, NORTHWEST CHINA
Authors: Chen Tingting , Qiu Menghan , Liu Ruiliang , Li Haiming , Hou Hongwei , Howarth Philly , Bowring Samantha , Zhou Aifeng 
Published: May 2020

ABSTRACTIn order to assess late prehistoric human responses to climate change in the Western Loess Plateau (WLP), we investigated 13,567 charred plant seeds and 19 radiocarbon (14C) dates obtained from 41 late prehistoric sites in the upper Wei River valley. Based on these new dating results as well as their cultural attributes, these sites could be confidently divided into four chronological phases (Phase 1: Late Yangshao and Majiayao culture; Phase 2: Qijia culture; Phases 3 and 4: Siwa culture) but a significant gap was identified at ca. 3600–3000 cal yr BP in this region. Comparison of this interval to high-resolution paleoclimate records from Tianchi Lake suggests it could be attributed to the dramatic drop in temperature at this time. Accordingly, archaeobotanical evidence with a refined chronology shows the adoption of cold-tolerant subsistence cereal grains such as barley on the NETP (Northeast Tibetan Plateau). Drawing from various lines of knowledge (chronology, palaeoclimate, archaeobotany, and archaeology), it is reasonable to conclude that, even when confronting a similar magnitude of climate change, local human societies could vary tremendously. Different subsistence strategies were brought in by the trans-Eurasia culture exchange of prehistoric times.
Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease
Authors: Hamilton Calum A. , Matthews Fiona E. , Donaghy Paul C. , Taylor John-Paul , O'Brien John T. , Barnett Nicola , Olsen Kirsty , McKeith Ian G. , Thomas Alan J. 
Published: May 2020

AbstractBackgroundMild cognitive impairment (MCI) may gradually worsen to dementia, but often remains stable for extended periods of time. Little is known about the predictors of decline to help explain this variation. We aimed to explore whether this heterogeneous course of MCI may be predicted by the presence of Lewy body (LB) symptoms in a prospectively-recruited longitudinal cohort of MCI with Lewy bodies (MCI-LB) and Alzheimer's disease (MCI-AD).MethodsA prospective cohort (n = 76) aged ⩾60 years underwent detailed assessment after recent MCI diagnosis, and were followed up annually with repeated neuropsychological testing and clinical review of cognitive status and LB symptoms. Latent class mixture modelling identified data-driven sub-groups with distinct trajectories of global cognitive function.ResultsThree distinct trajectories were identified in the full cohort: slow/stable progression (46%), intermediate progressive decline (41%) and a small group with a much faster decline (13%). The presence of LB symptomology, and visual hallucinations in particular, predicted decline v. a stable cognitive trajectory. With time zeroed on study end (death, dementia or withdrawal) where available (n = 39), the same subgroups were identified. Adjustment for baseline functioning obscured the presence of any latent classes, suggesting that baseline function is an important parameter in prospective decline.ConclusionsThese results highlight some potential signals for impending decline in MCI; poorer baseline function and the presence of probable LB symptoms – particularly visual hallucinations. Identifying people with a rapid decline is important but our findings are preliminary given the modest cohort size.
John Webster on the task of a properly theological theologia
Authors: Wittman Tyler 
Published: May 2020

AbstractThe late John Webster advocated both for a theological theology and a robust recovery of God's intrinsic perfection. This article examines how both occupations are related in Webster's thought by setting forth six statements summarising his doctrine of God and his theological approach to it. According to Webster, the doctrine of God is theological to the extent it upholds the principle of solus Deus in theology's formal and material consideration of God's perfection. Only thus does theology articulate the crucial distinction between and yet correspondence of God's antecedent perfection and God's intimate presence with us.
At the bedside: A theological consideration of the role of silence and touch in the accompaniment of the dying
Authors: Khalid Hina 
Published: May 2020

AbstractThis essay situates two embodied practices of palliative care, namely, the act of sitting with another in silence, and the act of gentle touch, within the broader conceptual framework ofcreatio ex nihilo. Centring on themes of particularity, creatureliness, and relationality, I argue that these practices, understood theologically, can be reframed as active participations in the self-giving love of God – thus setting forth a mode of loving relation with the dying person, rooted in a deep, attentive presence.
The Bonhoeffer dilemma: Sanctification as the increasing awareness of moral chaos
Authors: Powers Brian S. 
Published: May 2020

AbstractDietrich Bonhoeffer's pursuit of a sanctified life took a significant detour from the way in which he thought it would proceed. In seeking ‘good’ moral choices in the crucible of Nazi Germany, Bonhoeffer experienced a profound sense of what we now would recognise as moral injury, which proves to be a powerful and reflexive lens with which to examine his understanding of sanctification. Initially embracing pacifism as a fundamental pillar of Christian life, Bonhoeffer eventually became convinced that there are no pure or ‘right’ moral choices, only competing ‘wrong’ ones. He later wrote from prison that to be like Christ, and to come closer to holiness, was not to seek to avoid guilt, but to take on guilt for the sake of others. This recontextualisation of the idea of sanctification through the lens of Christ's substitutionary guilt suggests that for the responsible actor moral injury may be inevitable.
Control Policies for a Large Region of Attraction for Dynamically Balancing Legged Robots: A Sampling-Based Approach
Authors: Bhounsule Pranav A. , Zamani Ali , Krause Jeremy , Farra Steven , Pusey Jason 
Published: May 2020

SUMMARYThe popular approach of assuming a control policy and then finding the largest region of attraction (ROA) (e.g., sum-of-squares optimization) may lead to conservative estimates of the ROA, especially for highly nonlinear systems. We present a sampling-based approach that starts by assuming an ROA and then finds the necessary control policy by performing trajectory optimization on sampled initial conditions. Our method works with black-box models, produces a relatively large ROA, and ensures exponential convergence of the initial conditions to the periodic motion. We demonstrate the approach on a model of hopping and include extensive verification and robustness checks.
Autonomous Social Robot Navigation using a Behavioral Finite State Social Machine
Authors: Malviya Vaibhav , Reddy Arun Kumar , Kala Rahul 
Published: May 2020

SUMMARYWe present a robot navigation system based on Behavioral Finite State Social Machine. The paper makes a robot operate as a social tour guide that adapts its navigation based on the behavior of the visitors. The problem of a robot leading a human group with a limited field-of-view vision is relatively untouched in the literature. Uncertainties arise when the visitors are not visible, wherein the behavior of the robot is adapted as a social response. Artificial potential field is used for local planning, and a velocity manager sets the speed disproportional to time duration of missing visitors.
Illicit trades and smuggling activities on the island of Stromboli, 1808–1816: gender roles during a commercial crisis
Authors: Fazio Ida 
Published: May 2020

AbstractThis article examines the impact of the Continental Blockade upon a local fishing and agricultural economy in the Mediterranean by focusing on the illicit trades that flourished on Stromboli. The island became a strategic location for smuggling between the warring kingdoms of British allied Naples and French ruled Sicily. This paper argues that the Blockade allowed Stromboli to join the network of maritime traffic that had been dominated by the two biggest islands in the archipelago. Although equally integrated into agriculture and fishing, women participated in the fraudulent sale of prize goods but were excluded from large-scale smuggling operations.
THE EFFECTS OF L1–L2 PHONOLOGICAL MAPPINGS ON L2 PHONOLOGICAL SENSITIVITY
Authors: Kim Jeong-eun , Cho Yejin , Cho Youngsun , Hong Yeonjung , Kim Seohyun , Nam Hosung 
Published: May 2020

AbstractThis study examines the effects of asymmetrical mappings of L2 sounds to L1 sounds on real-time processing of L2 phonology. L1-Korean participants completed a self-paced listening (SPL) task paired with a picture verification (PV) task, in which an English sentence was presented word by word along with a picture that matched or mismatched the sentence. In the critical region, an L2 vowel was deliberately replaced with the wrong vowel for two types of English vowel pairs: Type 1: English vowel pairs showing a one-to-one mapping to Korean counterparts (e.g., English: /i/ and /æ/ to Korean /i/ and /æ/, respectively); and Type 2: English vowel pairs showing a two-to-one mapping to a Korean counterpart (e.g., English /i/ and /ɪ/ to Korean /i/). We analyzed response times (RTs) and PV accuracy. Longer RTs were observed for Type 1 errors than Type 2 errors, indicating lower sensitivity to L2 vowels with two-to-one mapping to an L1 vowel. Also, PV accuracy was lower for the sentences containing Type 2 errors. These results suggest that asymmetrical L2-L1 sound mapping can affect learners’ processing of L2 phonological knowledge, which in turn can negatively affect their comprehension.
Charting the trajectories of adopted children's emotional and behavioral problems: The impact of early adversity and postadoptive parental warmth
Authors: Paine Amy L. , Perra Oliver , Anthony Rebecca , Shelton Katherine H. 
Published: May 2020

AbstractChildren who are adopted from care are more likely to experience enduring emotional and behavioral problems across development; however, adoptees’ trajectories of mental health problems and factors that impact their trajectories are poorly understood. Therefore, we used multilevel growth analyses to chart adoptees’ internalizing and externalizing problems across childhood, and examined the associations between preadoptive risk and postadoptive protective factors on their trajectories. This was investigated in a prospective longitudinal study of case file records (N = 374) and questionnaire-based follow-ups (N = 96) at approximately 5, 21, and 36 months postadoptive placement. Preadoptive adversity (indexed by age at placement, days in care, and number of adverse childhood experiences) was associated with higher internalizing and externalizing scores; the decrease in internalizing scores over childhood was accelerated for those exposed to lower levels of preadoptive risk. Warm adoptive parenting was associated with a marked reduction in children's internalizing and externalizing problems over time. Although potentially limited by shared methods variance and lack of variability in parental warmth scores, these findings demonstrate the deleterious impact of preadoptive risk and the positive role of exceptionally warm adoptive parenting on children's trajectories of mental health problems and have relevance for prevention and intervention strategies.
Tramadol Promotes Oxidative Stress, Fibrosis, Apoptosis, Ultrastructural and Biochemical alterations in the Adrenal Cortex of Adult Male Rat with Possible Reversibility after Withdrawal
Authors: Shalaby Amany Mohamed , Aboregela Adel Mohamed , Alabiad Mohamed Ali , El Shaer Dina Fouad 
Published: May 2020

AbstractTramadol is a centrally acting analgesic drug, used for the management of moderate to severe pain in a variety of diseases. The long-term use of tramadol can induce endocrinopathy. This study aimed to evaluate the effect of tramadol dependence on the adrenal cortex and the effect of its withdrawal. Thirty adult male rats were divided into three experimental groups: the control group, the tramadol-dependent group that received increasing therapeutic doses of tramadol orally for 1 month, and the recovery group that received tramadol in a dose and duration similar to the previous group followed by a withdrawal period for another month. Specimens from the adrenal cortex were processed for histological, immunohistochemical, enzyme assay, and quantitative real-time PCR (RT-qPCR) studies. Tramadol induced a significant increase in malondialdehyde level and a significant decrease in the levels of glutathione peroxidase and superoxide dismutase. A significant decrease in the levels of adrenocorticotrophic hormones, aldosterone, cortisol, corticosterone, and dehydroepiandrosterone sulfate was also detected. Severe histopathological changes in the adrenal cortex were demonstrated in the form of disturbed architecture, swollen cells, and shrunken cells with pyknotic nuclei. Inflammatory cellular infiltration and variable-sized homogenized areas were also detected. A significant increase inP53andBaximmunoreaction was detected and confirmed by RT-qPCR. The ultrastructural examination showed irregular, shrunken adrenocorticocytes with dense nuclei. Dilated smooth endoplasmic reticulum, mitochondria with disrupted cristae, and numerous coalesced lipid droplets were also demonstrated. All these changes started to return to normal after the withdrawal of tramadol. Thus, it was confirmed that the long-term use of tramadol can induce severe adrenal changes with subsequent insufficiency.
An investigation into the impact of deprivation on demographic inequalities in adults
Authors: Mayhew Les , Harper Gillian , Villegas Andrés M. 
Published: May 2020

AbstractThis research investigates the impact of deprivation on demographic inequalities in England and Wales among adults. Using demographic measures including the modal age at death, life expectancy, lifespan variation and mortality, it shows a negative correlation with deprivation as measured by the 2015 Index of Multiple Deprivation. Although it finds that life expectancy is increasing overall and the gap between men and women is lessening, improvements are slower paced in more deprived areas such that the gap between rich and poor is slowly worsening over time. Men are more adversely impacted by deprivation than women with the gap in period life expectancy at age 30 in 2015 between the top and bottom 1% of deprived neighbourhoods at 10.9 years for men and 8.4 years for women. Between 2001 and 2015 inequalities in male mortality rates at age 44 were 4.4 times greater in the most deprived 10% of neighbourhoods than those in the 10% least deprived and were much higher than in intervening deciles. The worst deprivation is concentrated in specific areas. For example, in 22 out of 326 English districts, 25% or more of neighbourhoods are in the most deprived 10% and in 5 districts it is 40% or above.
Asymmetry in mortality volatility and its implications on index-based longevity hedging
Authors: Zhou Kenneth Q. , Li Johnny Siu-Hang 
Published: May 2020

AbstractMortality volatility is crucially important to many aspects of index-based longevity hedging, including instrument pricing, hedge calibration and hedge performance evaluation. This paper sets out to develop a deeper understanding of mortality volatility and its implications on index-based longevity hedging. First, we study the potential asymmetry in mortality volatility by considering a wide range of generalised autoregressive conditional heteroskedasticity (GARCH)-type models that permit the volatility of mortality improvement to respond differently to positive and negative mortality shocks. We then investigate how the asymmetry of mortality volatility may impact index-based longevity hedging solutions by developing an extended longevity Greeks framework, which encompasses longevity Greeks for a wider range of GARCH-type models, an improved version of longevity vega, and a new longevity Greek known as “dynamic Delta”. Our theoretical work is complemented by two real-data illustrations, the results of which suggest that the effectiveness of an index-based longevity hedge could be significantly impaired if the asymmetry in mortality volatility is not taken into account when the hedge is calibrated.
Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R
Authors: Bugide Suresh , Parajuli Keshab Raj , Chava Suresh , Pattanayak Rudradip , Manna Deborah L. Della , Shrestha Deepmala , Yang Eddy S. , Cai Guoping , Johnson Douglas B. , Gupta Romi 
Published: May 2020

AbstractBRAF inhibitors (BRAFi) have been approved for the clinical treatment of BRAF-mutant metastatic melanoma. Although initial responses to BRAFi are generally favorable, acquired BRAFi resistance emerges rapidly, resulting in treatment failure. Only some of the underlying mechanisms responsible for BRAFi resistance are currently understood. Here, we showed that the genetic inhibition of histone acetyltransferase 1 (HAT1) in BRAF-mutant melanoma cells resulted in BRAFi resistance. Using quantitative immunofluorescence analysis of patient sample pairs, consisting of pre-treatment along with matched progressed BRAFi + MEKi-treated melanoma samples, HAT1 downregulation was observed in 7/11 progressed samples (~63%) in comparison with pre-treated samples. Employing NanoString-based nCounter PanCancer Pathway Panel-based gene expression analysis, we identified increased MAPK, Ras, transforming growth factor (TGF)-β, and Wnt pathway activation in HAT1 expression inhibited cells. We further found that MAPK pathway activation following the loss of HAT1 expression was partially driven by increased insulin growth factor 1 receptor (IGF1R) signaling. We showed that both MAPK and IGF1R pathway inhibition, using the ERK inhibitor SCH772984 and the IGF1R inhibitor BMS-754807, respectively, restored BRAFi sensitivity in melanoma cells lacking HAT1. Collectively, we show that the loss of HAT1 expression confers acquired BRAFi resistance by activating the MAPK signaling pathway via IGF1R.
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth
Authors: Liu Yang , Jin Mingpeng , Wang Yaya , Zhu Jianjun , Tan Rui , Zhao Jing , Ji Xiaoying , Jin Chao , Jia Yongfeng , Ren Tingting , Xing Jinliang 
Published: May 2020

AbstractMitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial calcium (Ca2+) homeostasis. Dysregulation of mitochondrial Ca2+ homeostasis has been implicated in various cancers. However, it remains unclear whether MCU regulates mitochondrial Ca2+ uptake to promote cell growth in colorectal cancer (CRC). Therefore, in the present study the expression of MCU in CRC tissues and its clinical significance were examined. Following which, the biological function of MCU-mediated mitochondrial Ca2+ uptake in CRC cell growth and the underlying mechanisms were systematically evaluated using in in vitro and in vivo assays, which included western blotting, cell viability and apoptosis assays, as well as xenograft nude mice models. Our results demonstrated that MCU was markedly upregulated in CRC tissues at both the mRNA and protein levels. Upregulated MCU was associated with poor prognosis in patients with CRC. Our data reported that upregulation of MCU enhanced the mitochondrial Ca2+ uptake to promote mitochondrial biogenesis, which in turn facilitated CRC cell growth in vitro and in vivo. In terms of the underlying mechanism, it was identified that MCU-mediated mitochondrial Ca2+ uptake inhibited the phosphorylation of transcription factor A, mitochondrial (TFAM), and thus enhanced its stability to promote mitochondrial biogenesis. Furthermore, our data indicated that increased mitochondrial Ca2+ uptake led to increased mitochondrial production of ROS via the upregulation of mitochondrial biogenesis, which subsequently activated NF-κB signaling to accelerate CRC growth. In conclusion, the results indicated that MCU-induced mitochondrial Ca2+ uptake promotes mitochondrial biogenesis by suppressing phosphorylation of TFAM, thus contributing to CRC cell growth. Our findings reveal a novel mechanism underlying mitochondrial Ca2+-mediated CRC cell growth and may provide a potential pharmacological target for CRC treatment.