bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thinner biological tissues induce leaflet flutter in aortic heart valve replacements
Authors: Johnson Emily L. , Wu Michael C. H. , Xu Fei , Wiese Nelson M. , Rajanna Manoj R. , Herrema Austin J. , Ganapathysubramanian Baskar , Hughes Thomas J. R. , Sacks Michael S. , Hsu Ming-Chen 
Published: July 2020

Significance
Percutaneous valve replacement procedures enable the deployment of bioprosthetic heart valves through a catheter, which offers a minimally invasive option to treat valvular heart disease. Although these bioprostheses typically employ thinner leaflet tissues to accommodate the collapsed valve dimensions, the impact of using such tissues remains poorly understood. This study used high-fidelity computational methods to model realistic aortic valve implants and analyze the behavior of thinner tissues in the valvular system. The results from this investigation provide essential knowledge about a previously understudied phenomenon and indicate that thinner, more flexible biological tissues induce significant leaflet flutter during the cardiac cycle. This observed response introduces blood flow disturbances and leaflet irregularities that can lead to cardiovascular dysfunction and reduced valve durability.
The pragmatics of text-emoji co-occurrences on Chinese social media
Authors: Yang Xiran , Liu Meichun 
Published: July 2020

Abstract
This paper explores the pragmatics of emojis co-occurring with or embedded in text on Chinese social media with
this central research question: what are the patterns and the communicative functions manifested by emojis in co-occurrence with
Chinese text? Building on the metafunctional approach of multimodal analysis, popular online posts from Sina Weibo which contain
both emoji(s) and text have been collected and analyzed to discover the representational, interactive, and compositional features
manifested by emojis co-occurring with text. We have found that these emojis on Weibo appear most frequently at the end of the
posts and reflect some unique Chinese cultural and linguistic features. Based on recurring pragmatic and functional patterns of
text-emoji co-occurrences, it is proposed that emojis are used to perform speech acts, highlight subjective interpretations, and
enhance informality, while substituting, reinforcing, and complementing the meanings conveyed by verbal language.
MiR-9-5p inhibits mitochondrial damage and oxidative stress in AD cell models by targeting GSK-3β
Authors: Liu Junli , Zuo Xiaoqin , Han Jixiang , Dai Qingxiang , Xu Huining , Liu Ying , Cui Sen 
Published: July 2020

Abstract
This study aims to investigate the effects and underlying mechanisms of overexpression microRNA-9-5p (miR-9-5p) on the Aβ-induced mouse hippocampal neuron cell line HT22. Different concentrations of Aβ25-35 (10, 20, 40, 80, and 160 μM) treatment were used to establish AD model in HT22 cells. The CCK-8 assay was used to measure the cell viability. The mRNA expression levels of miR-9-5p and glycogen synthase kinase-3β (GSK-3β) were determined by RT-qPCR. HT22 cell apoptosis was analyzed flow cytometry. MiR-9-5p was down-regulated in Aβ25-35-induced HT22 cells. GSK-3β is a functional target for miR-9-5p. MiR-9-5p overexpression inhibited Aβ25-35-induced mitochondrial dysfunction, cell apoptosis, and oxidative stress by regulating GSK-3β expression in HT22 cells. Furthermore, through targeting GSK-3β, overexpression of miR-9-5p partly activated nuclear factor Nrf2/Keap1 signaling, including part increases of Nrf2, HO-1, SOD-1, GCLC expression and slight decrease of Keap1 expression. Our results showed miR-9-5p may play a powerful role in the pathogenesis of AD.
Spatio-temporal characteristics of cultivated land fragmentation in different landform areas with a case study in Northeast China
Authors: Qian Fengkui , Chi Yanru , Lal Rattan , Lorenz Klaus 
Published: July 2020

ABSTRACT
Assessing the temporal and spatial characteristics of cultivated land fragmentation is necessary to identify management practices that can reduce negative environmental effects. Thus, the purpose of this study was to use principal component analysis and spatial autocorrelation to analyze the dynamic characteristics of cultivated land fragmentation in different landform areas in Liaoning Province, China, in terms of time and space. An additional objective was to match the changes with the natural and social environment to support the sustainable development of fragmented cultivated land. The results indicated that the evolutionary trends of cultivated land fragmentation in the central plain area showed a weakening trend, contrary to those observed in the western hilly and eastern mountainous areas. Moreover, the spatial distribution characteristics of cultivated land fragmentation in the western hilly area were generally “external low, internal high,” primarily because of the edge density of cultivated land patches. The spatial distribution characteristics of cultivated land fragmentation in the central plain area were generally “external high, internal low,” primarily because of the number and division of cultivated land patches. The spatial distribution characteristics of cultivated land fragmentation in the eastern mountainous area were generally “south low, north high” because of the division of cultivated land patches. These results can provide guidelines for planners, managers, decision-makers and others to formulate regulatory policies, identify land remediation areas, and promote the sustainable development of cultivated land.
Final report on supplementary comparison of national standards for liquid flow COOMET.M.FF-S2 (COOMET Project 406/UA/07)
Authors: Frahm E , Mickan B , Gulyuk V , Reut G , Zigmantas G , Benkova M , Kayumov M 
Published: July 2020

A supplementary comparison, COOMET.M.FF-S2, in the field of water flow was organized by the COOMET Technical Committee (TC) 1.4 Flow Measurement. The goal of the comparison was to confirm the calibration and measurement capabilities (CMC) of the participating national metrology institutes (NMIs) in the flow ranges between 0.5 m3/h and 5.0 m3/h, and, respectively, between 20.0 m3/h and 100.0 m3/h. This is the first comparison in the field of fluid flow which has been done by the COOMET TC Flow Measurement.
This report describes the comparison results of the following water flow facilities (NMIs): PTB (Braunschweig, Germany), National standards Centre of the Republic of Uzbekistan (Tashkent, Republic of Uzbekistan), LEI (Kaunas, Lithuania), SMU (Bratislava, Slovakia), BelGIM (Minsk, Belarus), VNIIR (Kazan, Russia).
The PTB was designated as the pilot lab of this comparison, due to the low measurement uncertainty of its water flow primary standard, in comparison to all participants, and because of its experience in leading and participating in previous international flow comparisons.
In order to cover a large flowrate range, two transfer standard packages were delivered to all involved NMIs of the inter-laboratory comparison. For low flowrate range and nominal diameter of 25 mm a turbine meter and an electromagnetic flowmeter were used as transfer standards. For upper flow rates two turbine meters with a nominal diameter of 80 mm were used. All calibrations were made during March 2009 until May 2012.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Final report on key comparison EURAMET.AUV.V-K2
Authors: Kolasa Joanna , Virovska Daniela 
Published: July 2020

This final report describes the results obtained in a key comparison of primary vibration calibration facilities. Two piezoelectric standard accelerometers (one single-ended as well one back-to-back type) were calibrated first at Central Office of Measures (GUM), acting as pilot and linking laboratory, and Bulgarian Institute for Metrology (BIM). The results of the BIM obtained in this comparison were linked to the CCAUV.V-K2 key comparison through the joint participation of the GUM. The degrees of equivalence were computed for BIM with respect to the CCAUV.V-K2 key comparison reference value.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Effect of incompatibility between healing agent and cement matrix on self-healing performance of intelligent cementitious composite
Authors: Xue Caihong , Li Wengui , Castel Arnaud , Wang Kejin , Sheng Daichao 
Published: July 2020

Abstract
Encapsulation-based intelligent self-healing cementitious composite with a potential of crack self-healing and closure is promising to recovery concrete from damage and improve the durability and serviceability of infrastructures. The efficiency of self-healing concrete were investigated, but limited studies have been conducted on effect of incompatibility between the self-healing agent and cement matrix on the cracking behaviour and recovery efficiency of crack-healed concrete. In this study, a coupled experimental and numerical investigations were adopted to understand the cracking behaviours of crack-healed cementitious composites using traction–separation law by extended finite element method (XFEM). Firstly, experimental investigation was conducted to characterize the properties and parameters of cement matrix and healing agent-crack interface to calibrate the traction–separation law. Then, various parameters of healing agent, cement matrix, and their interface on the performance of crack-healed cementitious composite was numerically analysed. The results indicate that to achieve excellent self-healing performance, it is vital to consider the incompatibility between healing agent and cement matrix in the design of intelligent self-healing cementitious composites.
Strong lattice anharmonicity exhibited by the high-energy optical phonons in thermoelectric material
Authors: Wu Peng , Fan Feng-Ren , Hagihala Masato , Kofu Maiko , Peng Kunling , Ishikawa Yoshihisa , Lee Sanghyun , Honda Takashi , Yonemura Masao , Ikeda Kazutaka , Otomo Toshiya , Wang Guoyu , Nakajima Kenji , Sun Zhe , Kamiyama Takashi 
Published: July 2020

Abstract
Thermoelectric material SnSe has aroused world-wide interests in the past years, and its inherent strong lattice anharmonicity is regarded as a crucial factor for its outstanding thermoelectric performance. However, the understanding of lattice anharmonicity in SnSe system remains inadequate, especially regarding how phonon dynamics are affected by this behavior. In this work, we present a comprehensive study of lattice dynamics on Na0.003Sn0.997Se0.9S0.1 by means of neutron total scattering, inelastic neutron scattering, Raman spectroscopy as well as frozen-phonon calculations. Lattice anharmonicity is evidenced by pair distribution function, inelastic neutron scattering and Raman measurements. By separating the effects of thermal expansion and multi-phonon scattering, we found that the latter is very significant in high-energy optical phonon modes. The strong temperature-dependence of these phonon modes indicate the anharmonicity in this system. Moreover, our data reveals that the linewidths of high-energy optical phonons become broadened with mild doping of sulfur. Our studies suggest that the thermoelectric performance of SnSe could be further enhanced by reducing the contributions of high-energy optical phonon modes to the lattice thermal conductivity via phonon engineering.
Research on the Technology of Boulder Treatment in Urban Metro Tunnel Construction
Authors: Zhang G , Ran G Y , Hu H 
Published: July 2020

Abstract
With the development of shield tunneling in urban metro shield technology is applied more and more in complex layer. Taking the construction of Shenzhen Metro Line 5 as an example, in this paper the formation mechanism and distribution law of isolated boulder is deep analyzed, the difficult and risk of shield tunneling in the boulder existing mix ground is discussed, and the main methods and measures for the breaking of the boulder during construction is introduced. Through comparing of eight treatment method for boulder, the advantage and disadvantage of various processing methods is proposed, therefore it could apply to different project.
Optimization of Biogas-Fed Reversible Solid Oxide Fuel Cell System
Authors: Mungkalasiri W , Mungkalasiri J 
Published: July 2020

Abstract
In this work, an integrated system of biogas tri-reforming and solid oxide fuel cell (SOFC) for power generation was studied by using Aspen Plus simulation. Biogas obtained from a sugar industry with 75%CH4 and 25%CO2 was used as feedstock. However, biogas-feed SOFC power generation system released carbon dioxide (CO2) which was the main cause of global warming. Therefore, solid oxide electrolysis cell (SOEC) was considered for CO2 reduction called reversible solid oxide fuel cell (RSOFC). The RSOFC system included four units; tri-reforming, SOFC, SOEC and methanation. This research aimed to optimize operating conditions of the RSOFC system for generating maximum electricity and reducing CO2. The results of biogas tri-reforming with SOFC system showed that the electrical power production was 6233 W/m2 and CO2 emission was 1603 kg/hr. The results of RSOFC system indicated that CO2 emission was reduced by 24.7%.
70-year Evolution of China’s Environmental Policy —Based on the Analysis of Policy Text Using Nvivo 11.0
Authors: Liu Jiajie , Du George , Liu Weina , Zhang Dianwei 
Published: July 2020

Abstract
Reviewing the development of China’s environmental policy is of great significance to China’s policy formulation and environmental protection in other developing countries and regions. This research took the environmental policy texts 70 years ago, i.e. from the founding of New China as the research object, and used NVivo 11.0 software to analyze the text encoding. It sorted out and summarized the development process of China’s environmental policy: initial stage (1975-1991), difficult stage (1992-2002), exploration stage (2003-2012), and development stage (2013-2018). It shows evolution logic behind value rationality of China’s environmental policies, increasing policy suitability, and continuous optimization of policies.
The Smoke Spread Rule under Different Longitudinal Wind Speed in the Case of Fire in a Blocked Tunnel
Authors: Ran G Y , Zhang G , Zhang H , Sun J C 
Published: July 2020

Abstract
In recent years the development of the field of underground transportation is entering a new era. At the same time the loss caused by the tunnel fire is also incalculable. In the case of fire, its complex interior, less entrances and exits, and long evacuation routes bring great difficulties to the evacuation of people, often causing significant casualties and property losses. In this paper, FDS will be used to study the smoke spreading law of the tunnel with train blockage in terms of no mechanical ventilation and different ventilation speeds in different fire source locations. The results show that the critical wind speed of the tunnel with train blockage is lower than that of the tunnel without train blockage.
Challenges for Design Engineers in Sustainable Engineering
Authors: Deng Y M , Baeyens J , Zhang H L , Li S 
Published: July 2020

Abstract
Very few industrial processes only produce the target product, but other materials not desired by the manufacturer are also obtained. These unwanted products constitute the residues of the processes and their discharge contributes to the overall environmental impact. The concept of preventing pollution is gaining increased importance, and certain industries that are particularly similar in nature, could benefit from PPP (Pollution Prevention Program) cross-fertilization. Implementing PPP sets important targets and benefits. A number of codes of good practice lead to PPP, both from a management and technical viewpoints. The fast development of technology and pollution standards implies important challenges for environmental engineers, environmental research and development. Although there is no general route to success, there are however a number of pollution prevention and waste reduction schemes that apply. These alternatives and procedures are illustrated in the paper. It is clear that environment-caring companies will be more readily accepted by their human environment. It is also evident that the engineer of the 21st century faces new and complex environmental challenges. Research remains the backbone of successful development.
On the Outdoor Microclimates of Building Clusters in Cold Regions
Authors: Pan W , Mei H 
Published: July 2020

Abstract
Building clusters are settlements that are gradually formed by people living in cold regions after long-term resistance to the cold climate. For those facing extreme living environments, building clusters can effectively produce a cluster effect to generate a more comfortable outdoor microclimate for humans. In this paper, building clusters are summarized into 4 types, and a comparative study on the outdoor microclimates of the different types of building clusters is provided. In the study, the microclimate-based equivalent temperature (MBET) is used as the main parameter, and the micro-climate simulation software ENVI-met is used as a simulation tool. The results validate the important role of the building cluster type in producing the microclimate and provide a new basis for the type selection and design of building clusters in cold regions.
Dynamic pharmacy leadership during the COVID-19 crisis: Optimizing patient care through formulary and drug shortage management
Authors: Pulk Rebecca Ann , Leber Molly , Tran Lydia , Ammar Mahmoud , Amin Nilesh , Miller LeeAnn , Yazdi Marina 
Published: July 2020

Abstract

Purpose
The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges for health systems around the world. We describe our approach to adapting the pharmacy leadership structure to address critical medication shortages through innovative data analysis, procurement strategies, and rapid implementation of medication policy.

Summary
Yale New Haven Health deployed a system incident management command structure to effectively respond to the COVID-19 crisis. System pharmacy services adopted a similar framework to enable efficient communication and quick decision-making in key domains, including drug procurement and policy. By refining a model to project health-system medication needs, we were able to anticipate challenges and devise alternative treatment algorithms. By leveraging big data and creating a system knowledge base, we were able to consolidate reporting and coordinate efforts to ensure system success. Various procurement strategies were employed to ensure adequate supply, including frequent communication with our wholesaler, sourcing direct from suppliers, outsourcing of sterile products compounding to registered 503B outsourcing facilities, and acquisition of active pharmaceutical ingredients for compounding of essential medications. Strategic positioning of pharmacists within the health system’s incident command response teams and rapid adaption of drug use policy governance fueled accelerated response and nimble implementation. Communication was streamlined and executed via multiple outlets to reach a broad audience across the health system.

Conclusion
With medication shortages posing a threat to patient care, dynamic pharmacy leadership proved essential to providing patient care at the height of the COVID-19 pandemic. System alignment and the rapid adaption of the existing framework for drug shortage management and medication use policy were crucial to success in crisis response.
Medication utilization in patients in New York hospitals during the COVID-19 pandemic
Authors: Dabestani Arash , DeAngelo Dawn , Chhay Sophia R , Larson Bayli J , Ganio Michael C 
Published: July 2020

Abstract

Purpose
Utilization of hydroxychloroquine, chloroquine, and supportive therapy drugs in hospitals in New York during the early weeks of the coronavirus disease 2019 (COVID-19) pandemic was analyzed.

Summary
Drug utilization trends for 7 medications used to treat patients with suspected or confirmed COVID-19 at 47 New York hospitals were identified. The data demonstrated sharp increases in aggregate utilization of hydroxychloroquine and chloroquine and the number of patients receiving either drug beginning on March 15, with a notable 20% median increase per day through March 31. The net quantity of drug charge units per day for midazolam, propofol, ketamine, cisatracurium, and fentanyl also increased during the study period. Following peak utilization, use of all study drugs decreased at different times throughout April 2020. The data were used to provide information to various stakeholders in the drug supply chain during the initial surge of the pandemic.

Conclusion
This analysis describes the increased use, beginning in mid-March 2020, of hydroxychloroquine, chloroquine, midazolam, propofol, ketamine, cisatracurium, and fentanyl in 47 hospitals in New York State. The increased utilization of supportive therapy drugs was consistent with the surge in patients with presumed or confirmed COVID-19 during the study period. These data and observations can help clinicians, health-system leaders, manufacturers, wholesalers, and policymakers understand the impact of current and future pandemics on the drug supply chain.
Two decades of functional–structural plant modelling: now addressing fundamental questions in systems biology and predictive ecology
Authors: Louarn Gaëtan , Song Youhong 
Published: July 2020

AbstractBackgroundFunctional–structural plant models (FSPMs) explore and integrate relationships between a plant’s structure and processes that underlie its growth and development. In the last 20 years, scientists interested in functional–structural plant modelling have expanded greatly the range of topics covered and now handle dynamical models of growth and development occurring from the microscopic scale, and involving cell division in plant meristems, to the macroscopic scales of whole plants and plant communities.ScopeThe FSPM approach occupies a central position in plant science; it is at the crossroads of fundamental questions in systems biology and predictive ecology. This special issue of Annals of Botany features selected papers on critical areas covered by FSPMs and examples of comprehensive models that are used to solve theoretical and applied questions, ranging from developmental biology to plant phenotyping and management of plants for agronomic purposes. Altogether, they offer an opportunity to assess the progress, gaps and bottlenecks along the research path originally foreseen for FSPMs two decades ago. This review also allows discussion of current challenges of FSPMs regarding (1) integration of multidisciplinary knowledge, (2) methods for handling complex models, (3) standards to achieve interoperability and greater genericity and (4) understanding of plant functioning across scales.ConclusionsThis approach has demonstrated considerable progress, but has yet to reach its full potential in terms of integration and heuristic knowledge production. The research agenda of functional–structural plant modellers in the coming years should place a greater emphasis on explaining robust emergent patterns, and on the causes of possible deviation from it. Modelling such patterns could indeed fuel both generic integration across scales and transdisciplinary transfer. In particular, it could be beneficial to emergent fields of research such as model-assisted phenotyping and predictive ecology in managed ecosystems.