bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare cause for hematuria: Lymphoma of the urinary bladder
Authors: Mathew Sherin P , Parikh Sonia , Anand Asha , Srivastava Vaibhava 
Published: October 2020

AbstractPrimary lymphomas of the urinary bladder are rare and majority present with hematuria. Patients are usually elderly females with a history of recurrent cystitis. The diagnosis is clinched after imaging and biopsy of suspicious lesions in the bladder. The prognosis is good irrespective of the modality of treatment. With this background, we report a case of primary marginal zone lymphoma of the urinary bladder (Stage IE) in a young lady with no history of cystitis, who presented with isolated hematuria. After treatment with radiotherapy alone, patient is in complete remission for the past 18 months. The timely diagnosis in a patient with hematuria holds the key to successful treatment and its importance cannot be overemphasized.
Interleukin-6 versus C-reactive protein as markers for early detection of bacteremia in febrile neutropenia in pediatric population
Authors: Gupta Manasi , Kini Pushpa G , Bhat Y Ramesh , Aroor Shrikiran 
Published: October 2020

Abstract
Introduction: Systemic infection leading to multiorgan failure during neutropenia is one of the leading causes of treatment-related mortality among children receiving chemotherapy. Reliable markers are needed to diagnose or rule out infection, to reduce the empirical use of broad-spectrum antibiotic therapy. Aims and Objectives: The aim is to compare the role of interleukin-6 versus C-reactive protein (CRP) as markers of sepsis in febrile neutropenia in pediatric patients while on chemotherapy for malignancy. Materials and Methods: This was a prospective observational study carried out in the Department of Paediatrics of a tertiary care Hospital in South India. All children with malignancy in the age group from 1 month to 18 years diagnosed to have febrile neutropenia during any phase of chemotherapy were included in the study. Multiple episodes of febrile neutropenia in the same child were analyzed as separate episodes. Results: Thirty-two episodes of febrile neutropenia were analyzed. There were 7 microbiologically documented infections (MDI), 19 clinically documented infections and 6 episodes of fever of unknown origin. Out of the 7 MDI, 5 were Gram-negative sepsis and 2 were Gram-positive sepsis. Gram-negative sepsis had a much higher median IL-6 value (169) than Gram-positive sepsis (17.5) and sterile blood cultures (52). However, median value of CRP was only slightly higher in Gram-positive sepsis (85.5) than in Gram-negative sepsis (60.7) and sterile blood cultures (44.2). Conclusion: In this study, higher IL-6 values predicted Gram-negative sepsis better than CRP.
Long-term Remission of Metastatic Pleomorphic Paratesticular Rhabdomyosarcoma with Chemotherapy in an Adolescent Boy - A Case Report
Authors: Mehdi Intezar , Ranjani Shashi , Swamy Shivakumar , Venkatachala K 
Published: October 2020

AbstractRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. They are classified based on the histopathological characteristics. The prognosis of RMS depends on the site of occurrence and the histopathology. Although paratesticular site is considered as one of the favorable sites, pleomorphic histology, even at this favorable site, confers a poor prognosis. Treatment includes surgery chemotherapy and radiation in metastatic cases. Here, we describe a case of an adolescent boy with pleomorphic paratesticular RMS treated successfully with chemotherapy.
Uses of -diketones for the synthesis of novel heterocyclic compounds and their antitumor evaluations
Authors: M. Mohareb R. , M. Kamel M. , R. Milad Y. 
Published: October 2020

The reaction of the 3-oxo-N,3-diphenylpropan-amide (3) with either malononitrile or ethyl cyanoacetate in ammonium acetate gave the 1,2-dihydropyridine derivatives 6a or 6b, respectively. On the other hand, carrying the same reaction in the presence of triethylamine gave the 1,6-dihydropyridine derivatives 7a and 7b, respectively. Moreover, compound 3 reacted with 2-aminoprop-1-ene-1,1,3-tricarbonitrile to give the pyridine derivative 9. Compound 7b reacted with the active methylene derivatives 10a,b and 4a,b to give the naphthyridine derivatives 11a,b and 12a,b; respectively. Compound 3 was also used for the synthesis of thiophene derivatives 13a,b and 16a,b. In addition, the reaction of ethyl benzoylacetate (1) with o-phenylene diamine gave the benzimidazole derivative 18. The reactivity of the latter product towards different reagents was studied to give different products. The cytotoxicity of the newly synthesized products was studied towards some cancer and normal cell lines, in addition toxicity of compounds was measured and docking of the most active compounds was done. Compounds 6b, 7b, 9, 13a, 13b, 16a, 20b, 20c, 24b, 25 and 26b exhibited optimal cytotoxic effect against cancer tested cell lines. These active compounds were evaluated against c-Met kinase using foretinib as the reference drug where all compounds expressed higher activity than the reference drug.

KEY WORDS: Ethyl benzoylacetate, Pyridine, Benzimidazole, Cytotoxicity

Bull. Chem. Soc. Ethiop. 2020, 34(2), 385-405
DOI: https://dx.doi.org/10.4314/bcse.v34i2.15
Biochemical studies on protein, phenolic contents and antioxidant activities of Sida cordifolia extracts
Authors: Arshad S. , Hussain I. , Ibrahim M. , Imran M. , A. Assiri M. , Thind S. , Bilal M. , Irfan A. , G. Al-Sehemi A. 
Published: October 2020

The study aimed to characterize the antioxidant properties regarding the Sida cordifolia with special reference to its detailed biochemical analysis. The study revealed that chlorophyll A (0.9 ± 0.3 mg/g), total chlorophyll content (3.0 ± 0.7 mg/g), total carotenoid content (0.3 ± 0.1 mg/g), total soluble proteins (7.5 ± 0.1 mg/g), and total phenolic contents (5.6 ± 1.3 mg/g) were found highest in flower tissue of S. cordifolia. However, peroxidase (POD) contents (118 ± 31 units/g), superoxide dismutase (SOD) activity (64 ± 1.5 units/g) were maximum in the leaf tissues, while catalase (CAT) contents (133 ± 25 units/g), ascorbate peroxidase (APX) contents (145 ± 44 units/g) were also found more in the flowers of S. cordifolia rather than other parts. Our results conclude that leaves, stem, flower of S. cordifolia could be exploited in pharmacology due to presence of different antioxidants reflected in flower and leaf extract make them potent and profound therapeutic agents.

KEY WORDS: Alkaloids, Flavonoids, Phenolics, Antioxidant, Sida cordifolia

Bull. Chem. Soc. Ethiop. 2020, 34(2), 427-434
DOI: https://dx.doi.org/10.4314/bcse.v34i2.18
Construction of porous carbon for the highly efficient visible light-driven degradation methyl violet
Authors: Shi C. , Wang X. , Dong Y. , Hu W. , Li Y. , Pan Y. , Qiu Y. , Liu J. 
Published: October 2020

A series of nanoporous carbons (NPC) Fe-C/N-900 and C/N-900 have been synthesized from one-step carbonization of 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin-Fe (Fe-TCPP) and TCPP, respectively and employed as photocatalyst for the degradation of organic dye methyl violet (MV) under UV irradiation. The optimized Fe-C/N-900 (carbonized at 900 oC for 2 h) exhibited an optimal performance in MV degradation. The photodegradation capacity of Fe-C/N-900 has been observed to be higher than that of C/N-900. The photodegradation ability of Fe-C/N-900 as a function of initial MV concentration, catalysis dosage, and pH has been also investigated. The Fe-C/N-900 material showed no apparent loss in MV degradation after four cycles. These features reveal that Fe-C/N-900 may be a promising degradant for dyes removal from water.

KEY WORDS: Photocatalysis, Nanoporous carbons, Methyl violet, carbonization

Bull. Chem. Soc. Ethiop. 2020, 34(2), 277-284
DOI: https://dx.doi.org/10.4314/bcse.v34i2.6
Synthesis and characterization of novel four heterodimetallic mixed metal complexes of 2,6-pyridinedicarboxylic acid
Authors: İlkimen H. , S. Canlıdinç R. 
Published: October 2020

Four novel hetero dimetallic mixed metal complexes of 2,6-pyridinedicarboxylic acid (H2dipic), [Ni(H2O)5Co(dipic)2] (1), [Co(H2O)5Co(dipic)2][Ni(H2O)5Ni(dipic)2][Co(dipic)(H2O)3] (2), [Cu(H2O)5Ni(dipic)2]2[Co(dipic)(H2O)] (3) and [Ni(H2O)5Cu(dipic)2]2[Co(dipic)(H2O)] (4) have been prepared and characterized by elemental, AAS, spectral (IR and UV-Vis), and thermal analyses, as well as by using magnetic measurement and molar conductivity techniques. The results indicate that metal ions coordinate with 2,6-pyridinedicarboxylate ions (dipic2-) nitrogen atoms and carboxylate oxygen atoms of ligands. The mole ratio of dipic2- and metal ions in the complexes have been determined to be 2:2 (Co, Ni) for 1, 5:5 (3Co, 2Ni) for 2, 5:5 (Co, 2Ni and 2Cu) for 3 and 5:5 (Co, 2Ni and 2Cu) for 4 according to the results of elemental analysis. The structures of 1-4 might be proposed as octahedral ([Cu(dipic)(H2O)] unit for 2 square plane) according to results of spectroscopic analysis. The TG and DTA properties of compounds have been studied.

KEY WORDS: 2,6-Pyridinedicarboxylic acid, Mixed metal, Metal complex

Bull. Chem. Soc. Ethiop. 2020, 34(2), 313-321
DOI: https://dx.doi.org/10.4314/bcse.v34i2.9
Peppermint oil: A herbal solution for Irritable Bowel Syndrome
Authors: Moiz Ullah Khan  , Haris Jawaid  , Mustafa Ali  
Published: October 2020

Madam,
Irritable bowel syndrome (IBS) is a common gastrointestinal(GI) disorder, with a prevalence of approximately 11% worldwide and 13.3% in Pakistan.1-2 Symptoms of this disease are usually nonspecific, including bloating, abdominal discomfort with defecation, and change in bowel habits, resulting in most patients going without seeking treatment.2 Those who sought treatment did so due to a decreased quality of life (QoL) and higher anxiety, rather than increased severity of symptoms.2
Although the disease mortality is extremely low, studies have reported a strong association between depression (prevalence=38-100%) and decreased QoL in IBS patients.3 Moreover, IBS predisposes patients to a host of psychological disorders in addition to depression, which significantly impede treatment and lower QoL. As the disease pathophysiology remains largely unclear, treatment is focused mainly towards symptomatic relief and management.3 In addition to the available allopathic remedies, peppermint oil (PO) has emerged as a popular herbal alternative in recent years, and its efficacy and safety have been investigated by multiple studies.
A meta-analysis by Hawrelak et al. showed that PO was a significant improvement over placebo in alleviating abdominal pain (RR= 2.154, CI=1.56-2.94) and global symptoms of IBS (RR = 1.95, CI=1.46-2.62).4 PO is generally a safe treatment with few adverse effects; namely heartburn and perianal burning. Compared to other treatments such as tricyclic antidepressants and alosetron, it has a significantly higher benefit-to-harm ratio (25:1) second only to Rifaximin, and a small therapeutic dose (0.2mlx3-6 times/day).4
L-menthol, the primary active ingredient in PO, acts primarily as a calcium-channel antagonist in smooth muscles.5 Additionally, other compounds in PO, including menthone, menthyl acetate, isomenthone, etc contributed independently to its therapeutic effect via numerous mechanisms of action (MoA). These MoAs included but were not limited to antinociception via transient-receptor potential channels, GI histaminergic and cholinergic receptor modulation, serotonergic antagonism, and antiinflammatory effects.5
In countries like Pakistan where herbal medicines are often more popular than their allopathic counterparts, POs fit right in as an effective, alternative treatment that is scientifically proven. It can potentially serve as a valuable asset for IBS treatment in areas where access to medicine is limited, or where cost becomes an issue. These factors in association with its proven efficacy and lack of side effects merit its prescription by physicians as an alternative remedy for the treatment of IBS. Continuous...
O protagonismo e as práticas pedagógicas dos egressos da Licenciatura em Educação do Campo no contexto do território ribeirinho da Amazônia paraense tocantina
Authors: Dos Santos Jenijunio , Castagna Molina Mônica 
Published: October 2020

Tendo como parâmetro as dimensões da formação da Licenciatura em Educação do Campo- LEdoC: a docência, a gestão dos processos educativos escolares e a gestão dos processos educativos comunitários, bem como a formação de intelectuais comprometidos com a luta e a resistência dos territórios do campo, averígua-se as práticas dos egressos, da referida Licenciatura, do campus Abaetetuba, diretamente nos seus locais de atuação. Para efeito das análises buscou-se o aporte epistemológico do Materialismo Histórico Dialético, e como método a Pesquisa Participante e as técnicas Roda de Conversa; aplicação de formulários e realização de entrevistas. Concluiu-se que o Curso de Licenciatura em Educação do Campo de Abaetetuba, na contradição inerente ao movimento da realidade e mediado por uma práxis emancipatória, tem formado educadores que, pela prática pedagógica, produção do conhecimento e engajamento em lutas sociais, está contribuindo com os processos de resistência ao avanço do capital na Amazônia tocantina.
Palavras-chave: Licenciatura em Educação do Campo. Território Ribeirinho. Práticas pedagógicas. Educação do Campo.
IMPACT OF SELF-EFFICACY THEORY ON IMPROVING ADHERENCE OF OLDER ADULTS PATIENTS WITH GLAUCOMA’S MEDICATION
Authors: Abou-El-Soud Faiza A. , Mohamed Helalia Shalabi 
Published: October 2020

Purpose: This study was aimed to measure the impact of self-efficacy theory to improve medication adherence among older adults’ patients with glaucoma.
Methodology: A quasi-experimental design was used to investigate the study hypotheses.
Study Sample: A total of 284 older adults with glaucoma were screened to select non-adherent patients with medication. The recruited study sample was (152) who are non-adherent with glaucoma medication divided equally into (76 study group) and (76 control group). Setting: the study was conducted at the outpatient clinics of Ophthalmology at University Hospital, Shebin El-Kom, Egypt. Tools: three tools were used for the purpose of data collection (I) Bio-socio-demographic characteristics questionnaire; (II) Medication Adherence Rating Scale (III) Glaucoma Medication Self-Efficacy Scale.
Findings: The findings revealed that the mean age of the studied sample was 74.86+4.63 (non-adherent to medication). Patients age and presence of more than three multiple chronic illnesses with poly-medications are the highest risk factors of adherence to medications (OR = 10.9; 95% CI 6.8 -16.32, P = 0.000); (OR = 12.6; 95% CI 8.2 -18.4, P = 0.000) and (OR = 13.2; 95% CI 7.4 -19.8, P = 0.000) respectively. Participants who received the intervention program showed a significant improvement in their self-efficacy in overcoming medication adherence barriers compared to the control group. An improvement of the self-efficacy in their ability in carrying out glaucoma medication correctly compared to the control group was shown by highly statistically significant differences between total mean scores at (t =3.426, P =.001; t =17.174, P=.000; t =18.141, P=.000) respectively. The intervention program of glaucoma medication management had a positive impact on the patients’ outcomes compared to the control group. There is a statistically significant difference between patients’ feelings and thoughts pre and post-intervention was detected.
Unique contribution to theory, practice and policy: The findings confirm the effectiveness of an intervention/educational program based on self-efficacy theory in terms of improving glaucoma medication adherence among older adults. Glaucoma’s medication principles should be discussed at regular intervals based on patients' needs and the barriers they are facing.
Los materiales didácticos en la enseñanza de la historia y de las ciencias sociales en Argentina: percepciones del professorado.
Authors: Jara Miguel Angel 
Published: October 2020

Material educativo en la historia de las ciencias sociales y recursos que el profesor utiliza para desarrollar contenido con la intensidad de promover el aprendizaje. El libro de texto es uno de los que históricamente ha tenido más uso. Sin embargo, podemos sostener que, en realidad, la diversidad del material didáctico se ha incorporado a la educación, en diferentes formatos, y se ha ido desvelando la mayoría del texto como "el" recurso didáctico. En este escrito presentamos el análisis de los datos obtenidos del uso de un cuestionario que ha trabajado profesores y profesores en tres ciudades de Argentina: Cipolletti, Bahía Blanca y Mar del Plata en el marco de una formación de posgrado. Entre otras preguntas, preguntamos sobre el material y los recursos didácticos que generalmente se usan en las clases y sobre la valoración que el maestro hace de los mismos. En ambas dimensiones, hemos recuperado las percepciones del profesor, sobre lo que la didáctica de la historia ha contribuido en la formación inicial y las decisiones que ha tomado en sus prácticas docentes diarias.
Evaluación del clima institucional y el desempeño docente en las instituciones educativas del nivel primaria de la red N°11 del distrito de Villa María del Triunfo. Región Lima 2016
Authors: Bellido Corpus Elizabeth , Pando Ezcurra Tamara 
Published: October 2020

Es una investigación cuantitativa, transversal, bivariada, básica. Utilizamos un diseño descriptivo correlacional. Donde tenemos a los dos factores son el ambiente institucional y la ejecución del instructor en “el nivel primario de I.E Trabajada” La población está conformada por 12 I.E del nivel primaria de 500 docentes y la muestra constituida por 150 docentes de 8 escuelas. En la recolección de datos se diseñó 2 cuestionarios: La variable de la atmósfera institucional que instruye la ejecución.
Los instrumentos cumplen con la confiabilidad y validez. Tenemos la hipótesis “existe relación significativa entre el clima institucional y el desempeño docente en el nivel primaria de I.E Trabajada”
Los resultados rechazan la hipótesis nula, según se observa en los estadísticos, con un nivel de significación del 5%, existiendo evidencia estadística para afirmar que el desempeño docente tiene relación con el clima institucional, pues la correlación de Rho de Spearman da como resultado 0,850 la cual es considerada como “muy buena”. Por lo tanto, es rechazada la hipótesis nula y se toma que la “relación significativa entre el clima institucional y el desempeño docente en el nivel primaria de I.E Trabajada”.
PENGARUH LABEL HALAL TERHADAP PILIHAN KONSUMEN GERAI INDOMART PANUMBANGAN KABUPATEN CIAMIS
Authors: Hadaliah Lilis D , Maryani Sri 
Published: October 2020

This research aims to analyse the practice of halal labels as well as the process of consumer choice when choosing Halal products at Indomart Panumbangan. The data used in the study is primary data and secondary data. Primary Data is obtained directly from the survey dissemination to the research respondent. Secondary data is derived from literature, journals, or data related to research purposes. The population in this study is the consumer of Indomart Panumbangan, a sampling technique is a simple random sampling, a sampling of 50 people. Methods for collecting data using questionnaire or poll. The data analysis techniques in this study are validity and reliability tests, simple linear regression analyses as well as linear coefficient (R) analyses and determinations (R2). The results of the study showed the halal Label on each packaged food product offered at Indomart Panumbangan 90% of the official halal Label, the rest of which are labeled halal but not in accordance with the provisions of LPPOM MUI. The selection process on products labeled halal, consumers influenced cultural factors. From a variable X R2 test (Halal label) it affects 29.8% against Y (consumer choice). From simultaneous test results and variable X partial tests significantly affect the consumer's preference (Y).
Somnolencia diurna excesiva en estudiantes de la Facultad de Medicina de la Universidad Mayor de San Simón
Authors: Antezana Alejandro N. , Vallejos Rodrigo , Encinas Mabel , V. Antezana Erika , Antezana Ariel O. 
Published: October 2020

Objetivo: el objetivo primario es determinar si los estudiantes de medicina de la Universidad Mayor de San Simón (UMSS) sufren de somnolencia diurna excesiva mediante el uso de la Escala de somnolencia de Epworth (ESE).
Métodos: Se trata de un estudio transversal, descriptivo. Estudiantes de medicina de la UMSS completaron una encuesta la cual incluía datos demográficos, escala del sueño de Epworth traducida al español, número de horas nocturnas de sueño, siestas y uso de estimulantes del SNC durante el mes anterior a la realización de la encuesta.
Resultados: el universo consistió en 1923 estudiantes y la muestra en 324 estudiantes del primer al quinto curso de carrera de medicina (5% margen de error, 95% nivel de confianza); 57% del sexo femenino, media de edad de 21 años (±2,1), la media de la escala de Epworth fue de 9 (±3,3) (95% IC 8,46-9,54); 23,6% presentó algún grado de somnolencia diurna excesiva; 67% de los estudiantes indican dormir 4-6 hrs diarias; 79% goza entre 5 – 90 minutos de siesta cada día durante el mes anterior a la encuesta; 76% reporta usar algún tipo de estimulante del sistema nervioso central.
Conclusiones: un porcentaje menor pero relevante de estudiantes de medicina de la UMSS tiene algún grado de somnolencia diurna excesiva. Este menor porcentaje puede deberse al uso de siestas; habito comúnmente practicado en nuestro país.
El estrés innecesario durante el desarrollo de un trabajo de investigación
Authors: Mamani Ortiz Yercin 
Published: October 2020

Considerando que su revista es de difusión masiva en la comunidad científica local, aprovecho esta vía para poder llegar a los nuevos investigadores en salud, para motivarlos y plantearles algunas recomendaciones que les permitan evitar el estrés innecesario que se genera durante todo proceso de investigación. El nivel de estrés y su expresión biológica, psicológica u otra, dependerá de la capacidad de resiliencia que desarrolla cada investigador durante su formación y/o conducción de un trabajo de investigación, en cualquiera de los diferentes tipos de investigación.
Trombolisis intravenosa en ataque cerebrovascular isquémico agudo en Santa Cruz Bolivia: análisis retrospectivo de los primeros 18 casos
Authors: Camargo Villarreal Walter Mario , Urioste Avilés María Teresa , Camargo Jordán Walter Andrés , Ríos Sandra , Montero Jorge , Morales Oscar 
Published: October 2020

Objetivos: describir la experiencia en la implementación del protocolo de trombolisis i.v. en 18 pacientes con Accidente Cerebrovascular (ACV) isquémico en la Unidad de ACV de la Clínica Foianini, concretamente, entre septiembre de 2013 y julio de 2017.
Métodos: el estudio tiene un enfoque cuantitativo, tipo descriptivo y retrospectivo. Se revisó las historias clínicas de los pacientes con diagnóstico de ACV isquémico agudo, que fueron tratados con trombolitico intravenoso (Alteplasa) en el servicio UTAC, entre septiembre de 2013 y julio 2017 en Santa Cruz, Bolivia.
Resultados: el Tiempo Síntoma-Puerta alcanzo a 62,7 +/- 38 min, mientras que el Tiempo Puerta-Aguja fue de 53,6 +/- 15 min. y Tiempo Síntoma-Aguja 114,6 +/- 43 min. Se registraron complicaciones en 6 (33,3%). promedio de 4,6 +/- 3 días de internación en la clínica, pasando un promedio de 2,8 +/- 2 días en la Unidad de ACV. La tasa de mortalidad fue de 16,6%. Según la Escala Modficada de Rankin, tuvieron un puntaje de 0-1 mRS.
Conclusiones: el tiempo Puerta-Aguja en nuestro establecimiento fue de un promedio de 57 minutos, cumpliendo de esta forma la recomendación de la American Heart Association Guidelines 2013, la cual recalca que éste debe ser <60 min13.