bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choose to Move: A Health Promoting Physical Activity Intervention Can Also Enhance Social Connectedness
Authors: Franke Thea , Sims-Gould Joanie , Nettlefold Lindsay , Ottoni Callista , McKay Heather A. 
Published: September 2020

Abstract
Background: Despite the well-known health benefits of physical activity (PA), older adults are the least active citizens. Older adults are also at risk for loneliness. Given that lonely individuals are at risk for accelerated loss of physical functioning and health with age, PA interventions that aim to enhance social connectedness may decrease loneliness and increase long-term PA participation. The objectives of this mixed-method study are to: (1) evaluate whether an evidence-based PA intervention (Choose to Move; CTM) influenced PA and social connectedness differently among self-identified ‘lonely’ versus ‘not lonely’ older adults and (2) describe features of CTM that promote social connectedness.Methods: ﻿ Two community delivery partner organizations delivered 56 CTM programs in 26 urban locations across British Columbia. We collected survey data from participants (n=458 at baseline) at 0 (baseline), 3 (mid-intervention) and 6 (post-intervention) months. We conducted in depth interviews with a subset of older adults at baseline (n=43), mid-intervention (n=38) and post-intervention (n=19).Results: PA increased from baseline to 3 months in lonely and not lonely participants. PA decreased from 3-6 months in lonely participants; however, PA at 6 months remained above baseline levels in both groups. Loneliness decreased from baseline to 3 and 6 months in participants identifying as lonely at baseline. Features of CTM that influence social connectedness include: Activity coach characteristics/personality traits and approaches; opportunity to share information and experiences and learn from others; engagement with others who share similar/familiar experiences; increased opportunity for meaningful interaction; and accountability.Conclusion: PA interventions that focus on social connectedness, through group-based activities can improve the health of older adults by addressing both loneliness and PA. Building social connectedness within a PA intervention for older adults may support long term changes in PA behaviours.
Effect of alloying elements on thermal stability of Aluminium-Cerium based alloys
Authors: Saini Dheeraj Kumar , Gope Rahul , Mandal Animesh 
Published: September 2020

Abstract
The effect of alloying elements on thermal stability of five different near eutectic Al-Ce based alloys, i.e., Al-12Ce, Al-12Ce-4Si, Al-12Ce-0.4Mg, Al-12Ce-4Si-0.4Mg and Al-12Ce-4Si-0.4Mg-0.25Sr alloys were investigated. The alloys were heat treated at three different temperatures, i.e., 200 °C, 300 °C and 400 °C to establish the thermal stability. Binary Al-12Ce alloy consisting of α-Al and showed higher resistance to coarsening at all temperatures. Addition of Si decreases the thermal stability above 200 °C while combined addition of Si and Mg increases the thermal stability up to 300 °C. Addition of Sr to quaternary alloy was not beneficial to enhance the thermal stability.
Visual Short-term Memory Impairments in Presymptomatic Familial Alzheimer’s Disease: a Longitudinal Observational Study
Authors: Pavisic Ivanna M. , Nicholas Jennifer M. , Pertzov Yoni , O'Connor Antoinette , Liang Yuying , Collins Jessica D. , Lu Kirsty , Weston Philip S.J. , Ryan Natalie S. , Husain Masud , Crutch Sebastian J. , Fox Nick C. 
Published: September 2020

Abstract
Background: Cross-sectional studies in presymptomatic familial Alzheimer’s disease (FAD), have associated binding deficits with preclinical AD. How impairments in visual-short term memory (VSTM) relate to longitudinal change and proximity to expected symptom onset (EYO) is less characterized.Methods: Thirty-two FAD mutation carriers (23 presymptomatic; 9 symptomatic) carrying a mutation in either presenilin 1 or amyloid precursor protein genes and 67 healthy controls were included in an extension VSTM cross-sectional study. Forty-eight participants (23 presymptomatic carriers, 6 symptomatic and 19 healthy controls) who had at least two annual visits (median= 3), were included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Results: While cross-sectionally only symptomatic carriers (N=9) showed significant impairments in VSTM performance, longitudinally, presymptomatic carriers within 8.5 years of estimated symptom onset (mean=5.8 years ±SD [1.8], N=11) showed a faster rate of decline in localisation performance in long-delay conditions (4s) compared to controls: increase/year in localisation error was 6.9% greater in the high-memory load condition (p=0.008) and 7.0% greater for the low-memory load condition (p=0.043). Change in this metric preceded presymptomatic changes in traditional measures of verbal episodic memory. Symptomatic carriers had 15% faster reduction in identification performance per year compared to controls (p=0.036) and some evidence of faster increase in localisation error (6.5% increase/year; p=0.066). The earliest significant difference in VSTM performance between FAD mutation carriers (presymptomatic and symptomatic) and controls was in localisation performance, six years prior to estimated symptom onset (p=0.024). Conclusions: This longitudinal study of FAD, suggests changes in VSTM resolution, which measure precision and thus quality of recall of the memory presentation, may be sensitive markers for tracking and predicting cognitive decline in preclinical AD.
A Case of Ciprofloxacin-induced Acute Psychosis After Aortic Dissection Surgery
Authors: Song Guobao , Jiang Bo , Tan Shenglan , Li Feng 
Published: September 2020

Abstract
Ciprofloxacin is widely used in general infected population, including patients with aortic dissection. Ciprofloxacin-mediated neurotoxicity has been observed in few reports, and some studies found ciprofloxacin may increase the incidence of aortic dissection or aortic aneurysm rupture. We report here a case of ciprofloxacin-induced acute psychosis after Sun’s total arch replacement and cardiopulmonary resuscitation. Based on the published literature and FDA hypothesis, we suggest that ciprofloxacin should be used cautiously in patients after aortic dissection surgery in the risk of drug-induced psychosis and residual dilated aortic rupture.
New reduced-risk agricultural nematicides - rationale and review
Authors: Desaeger Johan , Wram Catherine , Zasada Inga 
Published: September 2020

Abstract
The last decade has seen a sharp increase in nematicide research in the agricultural industry. As a result, several new synthetic nematicides have become available to growers, and several more are expected in the near future. This new interest in nematicides is directly related to the growing demand for safer and more selective products, and the increasing regulatory pressure on many of the traditional nematicides. This has led to a ban of several widely used fumigant (e.g. methyl bromide) and non-fumigant (e.g. aldicarb) nematicides. The loss of traditional nematicides, combined with a lack of replacement products and awareness of the damage that nematodes can cause, has not only raised concern among growers, but has also created new opportunities for the crop protection industry. Nematicides have become a priority, and many companies are now allocating significant research dollars to discover new nematicides. The new nematicides are very different from previous products: (i) they are more selective, often only targeting nematodes, and (ii) they are less toxic, and safer to use. This review article describes these new developments by discussing the challenges that are associated with finding new nematicides, reviewing the nature, characteristics, and efficacy of new nematicides, and discussing the impact they could have on future nematode management.
Radiological and chemical risk assessment from uranium concentrations in groundwater samples collected from Al-Kufa area, Iraq
Authors: Abojassim Ali Abid , Neama Hayder Hussan 
Published: September 2020

Abstract
In nature, uranium is composed of three isotopes, 238U, 235U, and 234U. Emitting alpha particles leads to radionuclides decay. The aim of this work is to set up a database for uranium concentrations in groundwater samples collected from Kufa city, Al-Najaf governorate, Iraq. Twenty four samples have been examined for detecting the presence of uranium levels using a CR-39 detector. The measured uranium concentrations were used to determine uranium isotopes with their ingested radiological toxicity risk (annual effective dose of uranium isotopes and excess cancer risk) and chemical toxicity risk (lifetime average daily dose and hazard quotient) from consumption of the water samples in the present study. The results show that the average value of uranium concentrations, uranium isotopes 238U, 235U, and 234U (1.20 ± 0.04) μg/L, (1.48 ± 0.06) Bq/L, (0.069 ± 0.002) Bq/L and (1.49 ± 0.06) Bq/L respectively. Also, it is concluded that the total average annual effective dose and excess cancer risk in all regions under study were (0.10 ± 0.004) mSv/y and (0.31 ± 0.013) × 10−3 respectively. Moreover, the average value lifetime average daily dose, and hazard quotient was 0.0389 ± 0.0016 μg/kg.day and 0.0649 ± 0.0026 respectively. All results of radiological and chemical risk assessment from uranium concentrations in groundwater samples collected from the Al-Kufa area when used as drinking water were within the global limitations of the organization International Commission on Radiological Protection (1.9 μg/L; 1 mSv/y and 0.18 mSv/y) and World Health Organization recommended (0.6 μg/kg/day). Finally, it can be concluded that uranium concentrations do not affect human health according to radiation contents.
Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach
Authors: Shah Ashish , Patel Vaishali , Parmar Bhumika 
Published: September 2020

Background:
Novel Corona virus is a type of enveloped viruses with a single stranded RNA enclosing helical
nucleocapsid. The envelope consists of spikes on the surface which are made up of proteins through which virus enters into
human cells. Until now there is no specific drug or vaccine available to treat COVID-19 infection. In this scenario, reposting
of drug or active molecules may provide rapid solution to fight against this deadly disease.

Objective:
We had selected 30 phytoconstituents from the different plants which are reported for antiviral activities against
corona virus (CoVs) and performed insilico screening to find out phytoconstituents which have potency to inhibit specific
target of novel corona virus.

Methods:
We had perform molecular docking studies on three different proteins of novel corona virus namely COVID-19
main protease (3CL pro), papain-like protease (PL pro) and spike protein (S) attached to ACE2 binding domain. The screening of the phytoconstituents on the basis of binding affinity compared to standard drugs. The validations of screened compounds were done using ADMET and bioactivity prediction.

Results:
We had screened five compounds biscoclaurine, norreticuline, amentoflavone, licoricidin and myricetin using insilico approach. All compounds found safe in insilico toxicity studies. Bioactivity prediction reviles that these all compounds
may act through protease or enzyme inhibition. Results of compound biscoclaurine norreticuline were more interesting as
this biscoclaurine had higher binding affinity for the target 3CLpro and PLpro targets and norreticuline had higher binding
affinity for the target PLpro and Spike protein.

Conclusion:
Our study concludes that these compounds could be further explored rapidly as it may have potential to fight
against COVID-19.
Darolutamide as a Second-Generation Androgen Receptor Inhibitor in the Treatment of Prostate Cancer
Authors: Abbasi Ali , Movahedpour Ahmad , Amiri Ahmad , Najaf Mohamad Samare , Mostafavi-Pour Zohreh 
Published: September 2020

Prostate cancer (PC) is known as the most frequent cancer among men in the
world. Androgen Deprivation Therapy (ADT) is one of the initial treatment approaches in
the PC therapy and various drugs can be used in routine Hormonal therapy for PC
therapy. Nevertheless, PC cells can survive and continue their growth via different
mechanisms which lead to their resistance to common treatments i.e., Enzalutamide.
olutamide (ODM-201) is a second-generation androgen receptor (AR) inhibitor with a
new chemical structure and has a high affinity to the AR. Darolutamide does not cross
the blood-brain barrier and for this reason, reduces the possibility of seizures.
Darolutamide can also inhibit the transcriptional activity of several AR mutant variants
(F877L, F877L/T878A, and H875Y/T878A), which are Enzalutamide resistant. In this
review, we reviewed the results of different studies: in vitro, animal model and phase 1,
2 and 3 clinical trials (ARADES, ARAFOR and ARAMIS). We shall discuss worldwide
phase 2 and 3 clinical trials (ARASENS and ODENZA) that are in progress, in order to
demonstrate the advantages of Darolutamide consumption in different groups of
patients.

:
Darolutamide has shown high potential in inhibiting the growth of MR49F (Enzalutamide
resistant PC cells) and VCaP (Castration-resistant PC cells) cell lines and transcriptional
activities of AR. Fewer doses of Darolutamide are needed compared to Enzalutamide.
The drug had significant anti-tumor activity and no effect on serum testosterone levels in
animal models. Darolutamide demonstrates its safety and efficacy in different studies
and was well tolerated nearly in all of the patients.
CoV-Seq, a New Tool for SARS-CoV-2 Genome Analysis and Visualization: Development and Usability Study
Authors: Liu Boxiang , Liu Kaibo , Zhang He , Zhang Liang , Bian Yuchen , Huang Liang 
Published: September 2020

Background
COVID-19 became a global pandemic not long after its identification in late 2019. The genomes of SARS-CoV-2 are being rapidly sequenced and shared on public repositories. To keep up with these updates, scientists need to frequently refresh and reclean data sets, which is an ad hoc and labor-intensive process. Further, scientists with limited bioinformatics or programming knowledge may find it difficult to analyze SARS-CoV-2 genomes.

Objective
To address these challenges, we developed CoV-Seq, an integrated web server that enables simple and rapid analysis of SARS-CoV-2 genomes.

Methods
CoV-Seq is implemented in Python and JavaScript. The web server and source code URLs are provided in this article.

Results
Given a new sequence, CoV-Seq automatically predicts gene boundaries and identifies genetic variants, which are displayed in an interactive genome visualizer and are downloadable for further analysis. A command-line interface is available for high-throughput processing. In addition, we aggregated all publicly available SARS-CoV-2 sequences from the Global Initiative on Sharing Avian Influenza Data (GISAID), National Center for Biotechnology Information (NCBI), European Nucleotide Archive (ENA), and China National GeneBank (CNGB), and extracted genetic variants from these sequences for download and downstream analysis. The CoV-Seq database is updated weekly.

Conclusions
We have developed CoV-Seq, an integrated web service for fast and easy analysis of custom SARS-CoV-2 sequences. The web server provides an interactive module for the analysis of custom sequences and a weekly updated database of genetic variants of all publicly accessible SARS-CoV-2 sequences. We believe CoV-Seq will help improve our understanding of the genetic underpinnings of COVID-19.
Implicit Attitudes and U.S. Tax Professionals' Reliance on Offshore Tax Professionals' Recommendations
Authors: Spilker Brian C. , Stewart Bryan W. , Wood David A. 
Published: September 2020

SYNOPSIS
Large accounting firms offshore a significant amount of tax work to professionals in India. Prior research suggests that individuals can have negative implicit attitudes toward people from different nationalities and that such attitudes can have undesired consequences. In this study, we measure a sample of U.S. tax professionals' implicit attitudes toward Indian persons using an Implicit Association Test (IAT) and find that participants have strong negative implicit attitudes toward Indian persons relative to U.S. persons. Nevertheless, participants do not evaluate the work of U.S. tax professionals any differently than the (identical) work of Indian tax professionals. Participants appear able to rise above their negative implicit attitudes and perform their tax work without bias in our experiment. However, it is important to acknowledge that negative implicit attitudes may result in biased behavior in contexts outside of our experiment.
Data Availability: Please contact the authors.
Tax Specific versus Generic Accounting-Based Textual Analysis and the Relationship with Effective Tax Rates: Building Context
Authors: Allen Eric , O'Leary Daniel E. , Qu Hao , Swenson Charles W. 
Published: September 2020

ABSTRACT
A growing literature, typically using “bags of words” dictionaries, examines the information content of text in financial accounting disclosures. We generate context for our text analysis to help predict effective tax rates using two approaches. First, we create tax-specific, expert-derived, dictionaries and, second, we generate the counts for those bags of words using text taken from tax-related discussions of the Form 10-K, as opposed to its entirety. We find that using expertise provides more information than simply using general accounting and finance dictionaries. In addition, we find that generating general accounting text variable values from tax-related content in the Form 10-K provides statistically significant improvement in model fit. Contrary to more generic accounting and finance word-based text analysis, we find that the signs on our positive and negative tax event dictionaries are different and are consistent with theoretical expectations through each of our modeled time periods.
PERSEPSI MAHASISWA TERHADAP PENGGUNAAN QUIZIZZ DALAM PEMBELAJARAN AKUNTANSI KONSOLIDASI BANK SYARIAH DI IAIN PONOROGO
Authors: Amri Muhtadin , Shobri Yuz Arija 
Published: September 2020

Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa terhadap efektivitas penggunaan aplikasi pembelajaran berbasis permainan (game based learning) yaitu Quizizz. Populasi penelitian adalah seluruh mahasiswa perbankan syariah semester 4 angkatan tahun 2018. Responden dalam penelitian ini berjumlah 200 mahasiswa yang sedang menempuh mata kuliah akuntansi konsolidasi bank syariah yaitu mahasiswa semester 4 jurusan perbankan syariah di fakultas ekonomi dan bisnis islam IAIN Ponorogo. Analisis data dilakukan menggunakan metode deskriptif yang dianalisis secara kuantitatif dan kualitatif. Data penelitian diperoleh dengan menyebarkan survey kepada seluruh sampel penelitian dengan memanfaatkan aplikasi google forms. Instrumen kuesioner diukur menggunakan 5 skala likert yaitu sangat tidak setuju, tidak setuju, kurang setuju, setuju dan sangat tidak setuju. Hasil penelitian menunjukkan bahwa secara umum mahasiswa menganggap penggunaan Quizizz untuk mengerjakan kuis yang ditugaskan sebelum perkuliahan secara tatap muka di kelas berdampak yang positif dalam kegiatan pembelajaran pada mata kuliah akuntansi konsolidasi bank syariah. Mahasiswa menganggap Quizizz merupakan aplikasi yang mudah digunakan, penggunaannya membuat perkuliahan menjadi lebih menyenangkan, meningkatkan penguasaan materi, dan menambah motivasi dan keaktifan mahasiswa dalam mempelajari mata kuliah akuntansi konsolidasi bank syariah. Terdapat beberapa keterbatasan dan permasalahan yang terdapat pada penggunaan Quizizz menurut mahasiswa, diantaranya adalah keterbatasan koneksi internet, batasan waktu yang diberikan terlalu sedikit, dan beberapa mahasiswa juga merasa perlu untuk dilakukan pembahasan tentang soal-soal yang dikerjakan melalui aplikasi Quizizz di kelas, sehingga diketahui jawaban mana yang benar dan jawaban mana yang salah.
Educação das relações étnico-raciais: um estudo de caso sobre os impactos da Lei nº 10.639/03 no cotidiano escolar
Authors: Silva Nanicleison José da , Almeida Maria das Graças Andrade Ataíde de 
Published: September 2020

O objetivo deste artigo é compreender as concepções de professores e estudantes de uma escola da Rede Estadual de Ensino de Pernambuco sobre o papel da história e cultura afro-brasileira e africana e a implementação da Lei nº 10.639/03 como instrumento de combate ao preconceito étnico-racial na escola. Para tanto, utilizamos como referencial teórico os estudos de Gomes (2005, 2008 e 2012), Munanga (2005), Gonçalves e Silva (2004), Orlandi (1999), Yin (1989), e outros autores que com seus escritos corroboraram com o desdobramento da pesquisa. No que concerne ao processo investigativo seguiu-se com entrevista aos professores do ensino médio, aplicação de questionário aos estudantes na faixa etária entre 16 e 19 anos e a utilização da metodologia qualiquantitativa (6 professores e 100 estudantes). A compreensão sobre a temática se justifica pela necessidade de desconstruir socialmente o preconceito e a discriminação racial que a população negra sofre. A escola tem um papel fundamental no processo de construção e reconstrução dos valores sociais, por isso os resultados da pesquisa sobre a questão racial no contexto escolar têm demonstrado, que o sistema de ensino brasileiro se baseia numa visão eurocêntrica, monocultora, discriminatória de caráter racista e excludente. Tudo isso corrobora com os mecanismos de exclusão tendo a escola dificuldade de cumprir o seu verdadeiro papel, que é a formação humana, educar, socializar e formar cidadãos compromissados com a transformação social.
Teacher-student relationships: An influence on the English teaching-learning process
Authors: Syahabuddin Khairiah , Fhonna Rahmi , Maghfirah Ulfa 
Published: September 2020

There are two main purposes navigated in this study; first of all, it was carried out to investigate the teacher-student relationship; secondly, it was also conducted to find out whether there was a correlation between teacher-student relationship and English teaching-learning process. A number of 14 teachers and 43 students participated in this study; they are from two publish junior high schools in Aceh, Indonesia. Questionnaires for the students and interviews with the teachers were used to discover the influence of the relationship between English teachers and students, and the problems that students faced during their interactions with the teachers. There were twenty-two items in the questionnaire and five questions in the interviews that the participants needed to answer. The collected data from the questionnaire were then analysed by using a Likert scale and the Pearson product-moment correlation coefficient, meanwhile, the data from the interviews were analysed by following the stages of Miles and Huberman‘s(1994) model. In the first junior high school, a significant correlation appeared between the teacher-student relationship and teaching-learning process, with the raw score of 0.745 that refers to a high correlation. The tcount was higher than the ttable (4.784≥2.100). However, at second junior high school, had no significant correlation detected between the two variables with the raw score of 0,401 that referred to moderate correlation, where tcount was lower than ttable (2.004≤2.097). This research is expected to have a beneficial impact on the English teaching-learning process especially in the areas of the two schools, where this study took place, as well as the teachers and educators from other institutions spread in Aceh and Indonesia in general.