bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Nonaugmented, Static Augmented, and Dynamic Augmented Suture Repair of the Ruptured Anterior Cruciate Ligament: A Systematic Review of the Literature
Authors: Hoogeslag Roy A.G. , Brouwer Reinoud W. , de Vries Astrid J. , Boer Barbara C. , Huis in ‘t Veld Rianne 
Published: February 2020

Background: Anterior cruciate ligament suture repair (ACLSR) was abandoned late last century in favor of anterior cruciate ligament (ACL) reconstruction (ACLR) because of overall disappointing results. However, in recent years there has been renewed and increasing interest in ACLSR for treatment of ACL ruptures. Several contemporary ACLSR techniques are being used, but any difference in effectiveness is unclear. Hypothesis: Contemporary nonaugmented (NA), static augmented (SA), and dynamic augmented (DA) ACLSR leads to (1) comparable outcomes overall and (2) comparable outcomes between proximal third, middle third, and combined ACL rupture locations (a) within and (b) between ACLSR technique categories. Study Design: Systematic review. Methods: An electronic search was performed in the MEDLINE and Embase databases for the period between January 1, 2010, and August 7, 2019. All articles describing clinical and patient-reported outcomes for ACLSR were identified and included, and outcomes for NA, SA, and DA ACLSR categories were compared. Results: A total of 31 articles and 2422 patients were included. The majority of articles (65%) and patients (89%) reported outcomes of DA ACLSR. Overall, there was high heterogeneity in study characteristics and level as well as quality of evidence (19 level 4; 7 level 3; 3 level 2; and 2 level 1). Most studies indicated excellent patient-reported outcomes. Overall, the variability in (and the maximum of) the reported failure rate was high within all ACLSR categories. The variability in (and the maximum of) the reported rate of all other complications was highest for DA ACLSR. Regarding ACL rupture location, the failure rate was highest in proximal ACL ruptures within the SA and DA ACLSR categories; rates of all other reported complications were highest in combined ACL ruptures within the DA ACLSR category. However, no studies in the NA category and only 1 study in the SA ACLSR category evaluated combined ACL ruptures. The majority of studies comparing ACLSR and ACLR found no differences in outcomes. Conclusion: The amount of high-quality evidence for contemporary ACLSR is poor. This makes it difficult to interpret differences among ACLSR categories and among ACL rupture locations and, though promising, to establish the role of ACLSR in the treatment of ACL ruptures. More high-quality large randomized clinical trials with longer follow-up comparing ACLSR and ACLR are needed.
Meeting Calorie and Protein Needs in the Critical Care Unit: A Prospective Observational Pilot Study
Authors: Yamamoto Shinobu , Allen Karen , Jones Kellie R , Cohen Sarah S , Reyes Kemuel , Huhmann Maureen B 
Published: February 2020

Background: Inadequate calorie and protein intake during critical illness is associated with poor clinical outcomes. Unfortunately, most critically ill patients do not consume adequate levels of these nutrients. An enteral formula with appropriate macronutrient composition may assist patients in meeting nutritional goals. Design: This study was a single center, prospective, observational study of 29 adults in the medical intensive care unit who required enteral nutrition for at least 3 days. Subjects received a calorically dense, enzymatically hydrolyzed 100% whey peptide-based enteral formula for up to 5 days to assess the ability to achieve 50% of caloric goals within the first 3 days (primary outcome), the daily percentage of protein goals attained and gastrointestinal tolerance (secondary outcomes). Result: A total of 29 subjects consented and began the study. Four subjects dropped out before first day and 25 subjects were included in analyses. Subjects were aged 55.5 ± 16.9 years with mean body mass index (BMI) of 27.9 ± 7.5 kg/m2. Most (92%) subjects were on a mechanical ventilator and experienced organ failure. At least 50% of caloric and protein goals were achieved in 78.9% and 73.7% of the subjects, respectively, during the first 3 days. Overall, 75.0 ± 26.3% and 69.3 ± 26.7% of calorie and protein goals were achieved using the study formula. Conclusions: Subjects fed enterally with a calorically dense, enzymatically hydrolyzed 100% whey peptide-based enteral formula exceeded 50% of caloric and protein goals in most critically ill subjects included in this study. Use of study formula did not lead to severe gastrointestinal intolerance.
Long-Term Outcome of Common Femoral Artery Endarterectomy In Octogenarians and Non-Octogenarians
Authors: Uhl Christian , Götzke Hannah , Zeman Florian , Woronowicz Sandra , Betz Thomas , Töpel Ingolf , Steinbauer Markus 
Published: February 2020

Objective: Arteriosclerotic disease of the common femoral artery can be treated by surgical or endovascular intervention. Elderly patients are said to have a worse outcome if treated by surgical means; however, data to support this theory are missing. Methods: Retrospective analysis of all patients who underwent common femoral artery endarterectomy between March 2007 and July 2018 in our clinic. Group 1 included all patients <80 years and Group 2 included all patients ⩾80 years. Endpoints were patency rates, limb salvage, and overall survival. Results: During this time period, 977 common femoral artery endarterectomies were performed. Indication was claudication in 61.5% and critical limb ischemia in 38.5%. Group 1 included 805 cases (82.4%) and Group 2 included 172 cases (17.6%). Thirty-day mortality was 2.7% (Group 1 = 1.6% versus Group 2 = 7.6%; p < 0.001) and 30-day major amputation was 1.1% (Group 1 = 0.7% versus Group 2 = 2.9%; p = .043). Primary patency and secondary patency were 84.2% and 96.8%, respectively, after 7 years. Limb salvage (93.7%, Group 1 = 94.1% versus Group 2 = 91.8%; p = .088) and overall survival (52.0%, Group 1 = 59.1% versus Group 2 = 15.7%; p = .006) were significantly different after the same time period. Multivariable analysis showed female gender to be a risk factor for loss of primary patency. Age ⩾ 80 years and ulcer or gangrene were risk factors for death. Statin use was beneficial to survival. Conclusions: Common femoral artery endarterectomy is a safe procedure with excellent long-term results. Octogenarians have an increased risk for perioperative mortality and major amputation.
Utility of Rapid Influenza Molecular Testing in an Outpatient Hemodialysis Unit: A Prospective Cohort Study
Authors: Kadatz Matthew , Payne Michael , Kiaii Mercedeh , Romney Marc G. , Karakas Loretta , Lawson Tanya , Marchuk Stan , Gill John , Lowe Christopher F. 
Published: February 2020

Background: Early initiation of antiviral therapy for individuals at risk for severe influenza infection is important for improving patient outcomes. Current guidelines recommend empiric antiviral therapy for patients with end-stage kidney disease presenting with suspected influenza infection. Rapid molecular influenza assays may reduce diagnostic uncertainty and improve patient outcomes by providing faster diagnostics compared to traditional batched polymerase chain reaction (PCR) testing. Objective: To determine the utility of implementing a rapid influenza PCR assay compared to the standard of care in a hemodialysis unit. Design: This is a prospective cohort study. Setting: A hospital-based dialysis unit in a tertiary care hospital. Patients: Adult patients with end-stage kidney disease on intermittent hemodialysis. Measurements: Patient characteristics, influenza PCR swab results, antibiotic prescriptions, antiviral prescriptions, emergency room visits and hospitalizations. Methods: From November 1, 2017 to March 31, 2018, we assigned samples collected from a single center, hemodialysis unit to be processed using a rapid influenza PCR (cobas® Influenza A/B & respiratory syncytial virus assay) or the standard of care (in-house developed multiplex PCR). Samples were assigned to the rapid PCR if the patient received dialysis treatment in the morning dialysis shift, while the remainder were processed as per standard of care. Study outcomes included the time from collection to result of nasopharyngeal swab, prescription of influenza antiviral therapy, time to receiving prescription, and the need for emergency department visit or hospitalization within 2 weeks of presentation. Results: During the study period, 44 patients were assessed (14 with the rapid PCR and 30 with the standard of care assay). Compared to conventional testing, the time to result was shorter using rapid PCR compared to conventional testing (2.3 vs 22.6 hours, P < .0001). Individuals who were tested using the rapid PCR had a tendency to shorter time to receiving antiviral prescriptions (0.7 days vs 2.1 days, P = .11), and fewer emergency department visits (7.1% vs 30%, P = .13) but no difference in hospitalizations (14.3% vs 30%, P = .46) within 2 weeks of testing. Limitations: This is a single center non-randomized study with a relatively small sample size. Patients who were tested using the standard of care assay experienced a delay in the prescription of antiviral therapy which deviates from recommended clinical practice. Conclusions: Rapid influenza molecular testing in the hemodialysis unit was associated with a shorter time to a reportable result and with a tendency to reduced time to prescription of antiviral therapy. Rapid molecular testing should be compared with standard of care (empiric therapy) in terms of economic costs, adverse events, and influenza-related outcomes.
Social Media and Teens: A Needs Assessment Exploring the Potential Role of Social Media in Promoting Health
Authors: Plaisime Marie , Robertson-James Candace , Mejia Lidyvez , Núñez Ana , Wolf Judith , Reels Serita 
Published: February 2020

Aims: Social media use is widespread in teens. But, few studies have developed recommendations on how social media can be used to promote teen health. The Philadelphia Ujima™ Coalition funded by the Office on Women’s Health conducted a needs assessment to explore social media as a health communication tool. This study aimed to identify (1) social media utilization practices, (2) strategies to effectively engage teens on social media, and (3) recommendations for teen health promotion on social media. Methods: A cross-sectional mixed methods study design was used, in which a survey was administered to 152 youth (ages: 13–18 years). In addition, four focus groups were conducted with 26 teens to elaborate on the quantitative findings. Results: We found that while 94.6% of teens use social media, only 3.5% reported using it to seek health-related information. However, when asked about specific topics (i.e., fitness, sexual health, nutrition), 66.7% to 91.7% reported health information seeking. Although, many teens were not able to identify reliable sources of information. Teens felt health messages should be attractive and tailored. Conclusion: Social media holds promise as an effective health communication tool; however, information must be reliable and composed of attractive messages tailored to meet teens’ diverse needs. The findings from this study are indicative of the critical need to further explore how social media platforms enhance usage in health promotion.
What’s Wrong with Temporary Protected Status and How to Fix It: Exploring a Complementary Protection Regime
Authors: Frelick Bill 
Published: February 2020

Executive Summary Temporary Protected Status (TPS) became part of the US protection regime in 1990 to expand protection beyond what had been available under the US Refugee Act of 1980, which had limited asylum to those who met the refugee definition from the United Nations’ 1951 Refugee Convention. The TPS statute authorized the attorney general to designate foreign countries for TPS based on armed conflict, environmental disasters, and other extraordinary and temporary conditions that prevent designated nationals from returning in safety. While providing blanket protection that very likely has saved lives, TPS has nonetheless proven to be a blunt instrument that has frustrated advocates on both sides of the larger immigration debate. This article evaluates the purpose and effectiveness of the TPS statute and identifies inadequacies in the TPS regime and related protection gaps in the US asylum system. It argues that TPS has not proven to be an effective mechanism for the United States to protect foreigners from generalized conditions of danger in their home countries. It calls for changing the US protection regime to make it more responsive to the risks many asylum seekers actually face by creating a broader “complementary protection” standard and a more effective procedure for assessing individual protection claims, while reserving “temporary protection” for rare situations of mass influx that overwhelm the government’s capacity to process individual asylum claims. The article looks at alternative models for complementary protection from other jurisdictions, and shows how the US asylum and TPS system (in contrast to most other jurisdictions) fails to provide a mechanism for protecting arriving asylum seekers who do not qualify as refugees but who nevertheless would be at real risk of serious harm based on cruel, inhuman, or degrading treatment or punishment or because of situations of violence or other exceptional circumstances, including natural or human-made disasters or other serious events that disturb public order, that would threaten their lives or personal security. The article proposes that the United States adopt an individualized complementary protection standard for arriving asylum seekers who are not able to meet the 1951 Refugee Convention standard but who would face a serious threat to life or physical integrity if returned because of a real risk of (1) cruel, inhuman, or degrading treatment or punishment; (2) violence; or (3) exceptional situations, for which there is no adequate domestic remedy.
A Novel Mechanism Underlying Multi-walled Carbon Nanotube-Triggered Tomato Lateral Root Formation: the Involvement of Nitric Oxide
Authors: Cao Zeyu , Zhou Heng , Kong Lingshuai , Li Longna , Wang Rong , Shen Wenbiao 
Published: February 2020

AbstractAbundant studies revealed that multi-walled carbon nanotubes (MWCNTs) are toxic to plants. However, whether or how MWCNTs influence lateral root (LR) formation, which is an important component of the adaptability of the root system to various environmental cues, remains controversial. In this report, we found that MWCNTs could enter into tomato seedling roots. The administration with MWCNTs promoted tomato LR formation in an approximately dose-dependent fashion. Endogenous nitric oxide (NO) production was triggered by MWCNTs, confirmed by Greiss reagent method, electron paramagnetic resonance (EPR), and laser scanning confocal microscopy (LSCM), together with the scavenger of NO. A cause-effect relationship exists between MWCNTs and NO in the induction of LR development, since MWCNT-triggered NO synthesis and LR formation were obviously blocked by the removal of endogenous NO with its scavenger. The activity of NO generating enzyme nitrate reductase (NR) was increased in response to MWCNTs. Tungstate inhibition of NR not only impaired NO production, but also abolished LR formation triggered by MWCNTs. The addition of NG-nitro-l-arginine methyl ester (l-NAME), an inhibitor of mammalian nitric oxide synthase (NOS)-like enzyme, failed to influence LR formation. Collectively, we proposed that NO might act as a downstream signaling molecule in MWCNT control of LR development, at least partially via NR.
Effects of no-till and rice varieties on nitrogen and phosphorus balance in rice fields
Authors: Yang Jiao , Liang Xinqiang , Li Hua , Chen Yanfeng , Tian Guangming 
Published: February 2020

Abstract
Background
Nutrient balance in rice paddy fields can change under different tillage management practices; however, the extent of the change may differ for various rice varieties. A field experiment was conducted over 2 successive years to clarify the effects of no-till and rice varieties on the apparent balance of nitrogen (N) and phosphorus (P). Four treatments: no-till/japonica rice (NTJ), no-till/glutinous rice (NTG), conventional tillage/japonica rice (CTJ), and conventional tillage/glutinous rice (CTG) with three replicates of each were established to test the hypothesis that no-till and japonica rice can improve the apparent balance of nutrients.

Results
The tillage method and rice variety had interactive effects on the apparent balance of N and P. After the 2-year experiment, total N and P pools in the 20 cm surface soil layer were highest under the NTJ treatment (4757.0 kg N ha−1, 2428.5 kg P ha−1) and lowest under the CTG treatments (4726.3 kg N ha−1, 2412.0 kg P ha−1). Under no-till conditions, japonica rice had higher grain yield but lower straw biomass than that of glutinous rice. NTG treatment significantly increased the N and P content in rice grains and straw. The environmental losses of N and P in the rice fields mainly occurred during the rice season. Based on nutrient balance estimation, N losses in the NTJ, NTG, and CTJ treatments were reduced by 15.03 kg N ha−1, 11.55 kg N ha−1, 6.72 kg N ha−1, respectively, as compared with that of the CTG treatment. The corresponding P losses were reduced by 8.02 kg P ha−1, 7.84 kg P ha−1, and 3.96 kg P ha−1. In terms of economic benefits, NTJ also resulted in the highest actual income (2724.25 US dollars) and the highest ratio of production investment (6.40).

Conclusion
No-till was more likely to maintain soil N and P nutrients than conventional tillage, and this advantage was most significant when planting japonica rice. In addition, no-till was conducive to N and P uptake by rice, but only japonica rice exhibited increased grain yield. Consequently, the NTJ treatment was recommended to improve the N and P balance.
Polychlorinated biphenyls in the drinking water source of the Yangtze River: characteristics and risk assessment
Authors: Cui Xiaoai , Dong Jing , Huang Zhifeng , Liu Chengyou , Qiao Xiaocui , Wang Xing , Zhao Xingru , Zheng Binghui , Shen Jinshan 
Published: February 2020

Abstract
Background
As the longest river in Asia, the Yangtze River flows through the most industrialized cities in China and provides critical ecological services for agriculture, industry, and transportation. Polychlorinated biphenyls (PCBs) have been banned for many years, but trace amounts of PCBs still exist as persistent organic pollutant in drinking water and are an ecotoxicological problem. In this work, we collected water, sediment, and suspended particulate matter (SPM) samples along the Yangtze River, to study the distribution and transport of PCBs for the risk assessment of the Yangtze River as a drinking water source.

Results
The ΣPCBs concentrations in water, sediment, and SPM ranged in 0.04–11 ng/L, 0.33–69 ng/g, and 0.72–153 ng/L, respectively. The main pollutants were PCB17, 18, 28, 47, and 118 in the Yangtze River. The ffSW value of PCB18 and PCB28 all exceeded 0.50, whereas the ffSW value of PCB47 and PCB118 (except for PCB118 at Y-4) was less than 0.50. The toxic equivalent quantity (TEQ) range of PCBs in water and in sediment was ND–5.55 pg-TEQ/L and ND–2.51 pg-TEQ/g, respectively.

Conclusions
In both water and sediment, lower chlorinated PCBs are dominant in the middle reaches and higher chlorinated PCBs are dominant at downstream. In contrast, SPM is dominated by tetra-CBs. The ffSW values reveal a net redissolution of lower PCBs from sediments to water but a net sorption of higher PCBs from water to sediment. The PCBs in water and sediment at downstream pose potential ecological risk, but the drinking water does not have a non-carcinogenic risk for humans.
Factors associated with antibiotic prescribing for acute bronchitis at a university health center
Authors: Morley Valerie J. , Firgens Emily P. C. , Vanderbilt Rachel R. , Zhou Yanmengqian , Zook Michelle , Read Andrew F. , MacGeorge Erina L. 
Published: February 2020

Abstract
Background
Antibiotics are not indicated for treating acute bronchitis cases, yet up to 70% of adult acute bronchitis medical visits in the USA result in an antibiotic prescription. Reducing unnecessary antibiotic prescribing for acute bronchitis is a key antibiotic stewardship goal set forth by the Centers for Disease Control and Prevention. Understanding what factors influence prescribing for bronchitis cases can inform antimicrobial stewardship initiatives. The goal of this study was to identify factors associated with antibiotic prescribing at a high-volume student health center at a large US university. The Pennsylvania State University Health Services offers on-campus medical care to a population of over 40,000 students and receives over 50,000 visits every year.

Methods
We conducted a retrospective chart review of acute bronchitis visits for the 2015–2016 academic year and used a multivariate logistic regression analysis to identify variables associated with antibiotic prescribing.

Results
Findings during lung exams increased the likelihood of an antibiotic prescription (rales OR 13.95, 95% CI 3.31–80.73; rhonchi OR 5.50, 95% CI 3.08–10.00; percussion abnormality OR 13.02, 95% CI 4.00–50.09). Individual clinicians had dramatically different rates of prescribing (OR range 0.03–12.3). Male patients were more likely than female patients to be prescribed antibiotics (OR 1.68, 95% CI 1.17–2.41). Patients who reported longer duration since the onset of symptoms were slightly more likely to receive prescriptions (OR 1.04 per day, 95% CI 1.03–1.06), as were patients who reported worsening symptoms (OR 1.78, 95% CI 1.03–3.10). Visits with diagnoses or symptoms associated with viral infections or allergies were less likely to result in prescriptions (upper respiratory tract infection (URI) diagnosis OR 0.33, 95% CI 0.18–0.58; sneezing OR 0.39, 95% CI 0.17–0.86; vomiting OR 0.31, 95% CI 0.10–0.83). An exam finding of anterior cervical lymphadenopathy was associated with antibiotic prescribing (tender OR 3.85, 95% CI 1.70–8.83; general OR 2.63, 95% CI 1.25–5.54).

Conclusions
Suspicious findings during lung examinations (rales, rhonchi, percussion abnormality) and individual healthcare providers were important factors influencing antibiotic prescribing rates for acute bronchitis visits. Patient gender, worsening symptoms, duration of illness, symptoms associated with viral infections or allergies, and anterior cervical lymphadenopathy also influenced prescribing rates.