bluuebunny/crossref_metadata_2025_split huggingface dataset:
TGFβ: Protecting PD-1 from mRNA Decay
Authors: Dougan Stephanie K. 
Published: December 2020

Abstract
Coordinated regulation of genes is key to determining cell fate. Although this is best understood for master regulator transcription factors, posttranscriptional regulation of mRNA stability and nuclear export can be equally effective at altering gene expression. Indeed, the heterogeneity of RNA-binding proteins and miRNAs suggests a deep complexity to posttranscriptional regulatory processes. In this issue, Wu and colleagues report a new mechanism for TGFβ-mediated immune suppression via regulation of mRNA-binding proteins in CD8+ T cells.
See article by Wu et al., p. 1470
Mapping Film Programming across Post-War Europe (1952)
Authors: van Oort Thunnis , Jernudd Åsa , Lotze Kathleen , Pafort-Overduin Clara , Biltereyst Daniël , Boter Jaap , Dibeltulo Silvia , Ercole Pier , Meers Philippe , Porubcanska Terezia , Gennari Daniela Treveri , Van de Vijver Liesbeth 
Published: December 2020

Abstract
This data paper and the data collection from which it emerges aim to present a fully harmonized data set originating in several research projects on post-war cinema programming. The paper will reflect on the collection and structure of this aggregated data set, that consists of titles of feature films screened for public viewing in cinemas in the cities Bari (Italy), Antwerp and Ghent (Belgium), Gothenburg (Sweden), Leicester (United Kingdom) and Rotterdam (Netherlands) for the year 1952. As comparisons of movie-going patterns between European countries are still rare, this paper offers a model for constructing a data set which can be replicated, scaled up and used to compare, contextualize, and eventually theorize practices of cinema-going across countries at a global level.
Long-Term Changes in Inland Water Surface Temperature across China Based on Remote Sensing Data
Authors: Wang Rui , Yan Xin , Niu Zhenguo , Chen Wei 
Published: December 2020

AbstractWater surface temperature is a direct indication of climate change. However, it is not clear how China’s inland waters have responded to climate change in the past using a consistent method on a national scale. In this study, we used Moderate Resolution Imaging Spectroradiometer (MODIS) data from 2000 to 2015 to study the temporal and spatial variation characteristics of water surface temperature in China using the wavelet transform method. The results showed the following: 1) the freezing date of China inland water has shown a significant delaying trend during the past 16 years with an average rate of −1.5 days yr−1; 2) the shift of the 0°C isotherm position of surface water across China has clear seasonal changes, which first moved eastward about 25° and northward about 15°, and then gradually moved back after the year 2009; 3) during the past 16 years, the 0°C isotherm of China’s surface water has gradually moved north by about 0.09° in the latitude direction and east by about 1° in the longitude direction; and 4) the interannual variation of water surface temperature in 17 lakes of China showed a similar fluctuation trend that increased before 2010, and then decreased. The El Niño and La Niña around 2010 could have impacts on the turning point of the annual variation of water surface temperature. This study validated the response of China’s inland surface water to global climate change and improved the understanding of the wetland environment’s response to climate change.
Comparison of intravesical instillation of hyaluronic acid with intradetrusor botulinum toxin A injection or cystoscopic hydrodistention for ketamine-associated cystitis
Authors: Li Bingkun , Leng Qu , Li Chuanyin , Tan Xiao , Su Wei , Li Chaoming 
Published: December 2020

Objective This study aimed to compare the therapeutic effect of intravesical instillation hyaluronic acid with intradetrusor botulinum toxin A (BTX-A) injection or cystoscopic hydrodistention for ketamine-associated cystitis. Methods Thirty-six patients were evenly randomly divided into the BTX-A group or the hydrodistention group. Patients received 200 U BTX-A detrusor injections in the BTX-A group and cystoscopic hydrodistention in the hydrodistention group. Intravesical instillation of hyaluronic acid was administrated in both groups for eight times. Patients with involuntary detrusor contraction were divided into the persistent involuntary detrusor contraction group and resolved involuntary detrusor contraction group after treatment in 6 months. The predictors of persistent involuntary detrusor contraction were analyzed. Results Twelve months after treatment, the daytime frequency, Interstitial Cystitis Symptom Index, maximal capacity, and maximal cystometric capacity in the BTX-A group were significantly better than those in the hydrodistention group. Patients with resolution of involuntary detrusor contraction had a significantly shorter duration of ketamine, lower amount of fibrosis in pathology, and higher maximal capacity than those with persistent involuntary detrusor contraction 6 months after therapy. Conclusion Intravesical instillation of hyaluronic acid with intradetrusor BTX-A injection appears to be a preferable option for long-term effectiveness compared with cystoscopic hydrodistention.
An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs
Authors: Holt Ian , Fuller Heidi R. , Schindler Roland F. R. , Shirran Sally L. , Brand Thomas , Morris Glenn E. 
Published: December 2020

AbstractBackgroundPopeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In order to identify novel protein interaction partners, POPDC1 and 2 proteins were attached to beads and compared by proteomic analysis with control beads in the pull-down of proteins from cultured human skeletal myotubes.ResultsThere were highly-significant interactions of both POPDC1 and POPDC2 with XIRP1 (Xin actin binding repeat-containing protein 1), actin and, to a lesser degree, annexin A5. In adult human skeletal muscle, both XIRP1 and POPDC1/2 were present at the sarcolemma and in T-tubules. The interaction of POPDC1 with XIRP1 was confirmed in adult rat heart extracts. Using new monoclonal antibodies specific for POPDC1 and POPDC2, both proteins, together with XIRP1, were found mainly at intercalated discs but also at T-tubules in adult rat and human heart.ConclusionsMutations in humanPOPDC1,POPDC2and in humanXIRP1, all cause pathological cardiac arrhythmias, suggesting a possible role for POPDC1/2 and XIRP1 interaction in normal cardiac conduction.
Digital health developments and drawbacks: a review and analysis of top-returned apps for bipolar disorder
Authors: Lagan Sarah , Ramakrishnan Abinaya , Lamont Evan , Ramakrishnan Aparna , Frye Mark , Torous John 
Published: December 2020

Abstract
Background
Although a growing body of literature highlights the potential benefit of smartphone-based mobile apps to aid in self-management and treatment of bipolar disorder, it is unclear whether such evidence-based apps are readily available and accessible to a user of the app store.

Results
Using our systematic framework for the evaluation of mental health apps, we analyzed the accessibility, privacy, clinical foundation, features, and interoperability of the top-returned 100 apps for bipolar disorder. Only 56% of the apps mentioned bipolar disorder specifically in their title, description, or content. Only one app’s efficacy was supported in a peer-reviewed study, and 32 apps lacked privacy policies. The most common features provided were mood tracking, journaling, and psychoeducation.

Conclusions
Our analysis reveals substantial limitations in the current digital environment for individuals seeking an evidence-based, clinically usable app for bipolar disorder. Although there have been academic advances in development of digital interventions for bipolar disorder, this work has yet to be translated to the publicly available app marketplace. This unmet need of digital mood management underscores the need for a comprehensive evaluation system of mental health apps, which we have endeavored to provide through our framework and accompanying database (apps.digitalpsych.org).
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
Authors: Han Mengzhen , Liao Zhibin , Liu Furong , Chen Xiaoping , Zhang Bixiang 
Published: December 2020

AbstractHepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned.
Cerebral organoids: emerging ex vivo humanoid models of glioblastoma
Authors: Papaioannou Michail-Dimitrios , Sangster Kevin , Sajid Rifat Shahriar , Djuric Ugljesa , Diamandis Phedias 
Published: December 2020

AbstractGlioblastoma is an aggressive form of brain cancer that has seen only marginal improvements in its bleak survival outlook of 12–15 months over the last forty years. There is therefore an urgent need for the development of advanced drug screening platforms and systems that can better recapitulate glioblastoma’s infiltrative biology, a process largely responsible for its relentless propensity for recurrence and progression. Recent advances in stem cell biology have allowed the generation of artificial tridimensional brain-like tissue termed cerebral organoids. In addition to their potential to model brain development, these reagents are providing much needed synthetic humanoid scaffolds to model glioblastoma’s infiltrative capacity in a faithful and scalable manner. Here, we highlight and review the early breakthroughs in this growing field and discuss its potential future role for glioblastoma research.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Authors: Wojtas Aleksandra M. , Carlomagno Yari , Sens Jonathon P. , Kang Silvia S. , Jensen Tanner D. , Kurti Aishe , Baker Kelsey E. , Berry Taylor J. , Phillips Virginia R. , Castanedes Monica Casey , Awan Ayesha , DeTure Michael , De Castro Cristhoper H. Fernandez , Librero Ariston L. , Yue Mei , Daughrity Lillian , Jansen-West Karen R. , Cook Casey N. , Dickson Dennis W. , Petrucelli Leonard , Fryer John D. 
Published: December 2020

AbstractThe molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To further elucidate the effect of CLU on tau pathology, we utilized a gene delivery approach in CLU knock-out (CLU KO) mice to drive expression of tau bearing the P301L mutation. We found that loss of CLU was associated with exacerbated tau pathology and anxiety-like behaviors in our mouse model of tauopathy. Additionally, we found that CLU dramatically inhibited tau fibrilization using an in vitro assay. Together, these results demonstrate that CLU plays a major role in both amyloid and tau pathologies in AD.
An isolated Posterolateral corner injury with rotational instability and hypermobile lateral meniscus: a novel entity
Authors: Goto Kazumi , Duthon Victoria , Menetrey Jacques 
Published: December 2020

AbstractPurposeAlthough complete tear of the knee posterolateral corner (PLC) commonly occurs in combination with other knee ligamentous injuries, the incidence of isolated PLC injury was reported only 28% and overlooked in many cases. Nevertheless, an isolated PLC injury does not only provoke posterolateral instability, but also may be associated to hypermobile lateral meniscus. This study aims at showing the characteristics of isolated PLC injuries and to alert potential overlooked cases by describing their arthroscopic findings and clinical characteristics.MethodsSeventy-one patients with a clinically proven isolated PLC injury who underwent knee arthroscopy were included in this study. Pre-operative symptoms and clinical signs at examination were recorded: Pain at the posterolateral aspect, feelings of instability, catching, locking; and for clinical signs: McMurray test, varus stress test in extension and at 30° of flexion, posterolateral drawer test at 30° and 80°, dial test at 30° and 80° of flexion. In terms of arthroscopic findings, systematic meniscal stability was performed to evaluate the presence of hypermobile lateral meniscus, “lateral drive through test” was also recorded in all cases.ResultsPositive Lateral Drive through test was found in 69 patients (95.8%). Hypermobile lateral meniscus was seen in all patients.ConclusionsHyper mobile lateral meniscus was concomitant with all isolated PLC injuries in our case series. As the typical arthroscopic characteristic, lateral drive through test positive were seen in 95.8%. In order to prevent overlooking this concomitant pathology, meticulous arthroscopic observation is crucial.Level of evidenceLevel IV.
Functional and aesthetic outcomes of spreader graft and auto-spreader flap after nasal hump removal
Authors: Naguib Maged Baher , Ahmed Mohamed Rifaat , Madian Yasser Taha , Elnahriry Tarek Mohamady , Eldeeb Wael Elshahat 
Published: December 2020

Abstract
Background
Following the reduction of the nasal hump to a desired level, spreader grafts are usually positioned to prevent the complication of nasal valve collapse. Auto-spreader flap is a new technique that gained more popularity recently and can be used as an alternative to spreader graft. This RCCT compared between both techniques aesthetically and functionally as well as the operative time.

Results
Forty patients, 17 males (42.5%) and 23 females (57.5%), were included. The mean duration of operation in auto-spreader flap was 11.8 ± 3.4 min, while it was 19.2 ± 3.2 min in spreader graft. The difference between the two procedures was statistically significant (P < 0.05). Functional assessment of nasal obstruction was done for all patients in both groups preoperative that was (75.6 ± 19.9) which showed marked improvement when re-evaluated 3 moths postoperatively (18.9 ± 14.7), and after 6 months NOSE scale was (29.1 ± 20.2). The overall aesthetic satisfaction was 62.5% (25 of 40) irrespective of the surgery done. Sixteen out of 20 patients in spreader group and 9 out of 20 in auto-spreader flap group.

Conclusion
Auto-spreader flap and spreader graft are very effective surgical procedure for treatment of nasal obstruction due to internal nasal valve dysfunction, but the auto-spreader flap had shorter operative time. However, spreader graft has a superior aesthetic outcome.
A Pilot Study Evaluating the Effects of Magtrace® for Sentinel Node Biopsy in Breast Cancer Patients Regarding Care Process Optimization, Reimbursement, Surgical Time, and Patient Comfort Compared With Standard Technetium99
Authors: Shams Sina , Lippold Kai , Blohmer Jens Uwe , Röhle Robert , Kühn Friedrich , Karsten Maria Margarete 
Published: December 2020

Abstract
Background
Sentinel lymph node biopsy after technetium-99 (Tc99) localization is a mainstay of oncologic breast surgery. The timing of Tc99 injection can complicate operating room schedules, which can cause increasing overall costs of care and patient discomfort.

Methods
This study compared 59 patients who underwent breast cancer surgery including sentinel lymph node biopsy. Based on the surgeon’s choice, 29 patients were treated with Tc99, and 30 patients received the iron-based tracer, Magtrace. The primary outcomes were time spent on the care pathway and operating time from commissioning of the probe to removal of the sentinel node. The secondary outcomes were patient pain levels and reimbursement.

Results
The mean time spent on the preoperative breast cancer care pathway was significantly shorter for the Magtrace group (5.4 ± 1.3 min) than for the Tc99 group (82 ± 20 min) (p < 0.0001). The median time from probe usage to sentinel node extirpation was slightly but not significantly shorter in the Magtrace group (5 min; interquartile range [IQR], 3–15 min vs 10 min; IQR, 7–15 min; p = 0.151). Reimbursement and pain levels remained unchanged, and the hospital length of stay was similar in the two groups (Magtrace: 5.1 ± 2.3 days vs Tc99: 4.5 ± 3.2 days).

Conclusions
Magtrace localization shortened the preoperative care pathway and did not affect surgical time or reimbursement. Once established, it could allow for cost reduction and improve patient comfort.
Numerical simulation and experiment on generation dynamics of a Ho3+-doped fiber laser with an intracavity Mach–Zehnder modulator
Authors: Fedoseev Anatolii I. , Filatova Serafima A. , Kamynin Vladimir A. , Kopyeva Mariya S. , Nanii Oleg E. , Smirnov Alexander P. , Tsvetkov Vladimir B. 
Published: December 2020

We present the numerical simulation and experimental results on generation dynamics of an all-fiber holmium laser with an intracavity modulator based on a Mach–Zehnder interferometer. The experimental data were compared with numerical simulation results in a wide range of parameters. An explanation for the observed increase in the pulse repetition rate from 5.8 to 11.6 kHz, as well as the transition to the chaotic pulsations mode, was given. A numerical variation of the unknown or difficult-to-measure losses in the experiment was carried out. The obtained set of parameters allowed us to implement the correct numerical optimization of an active medium and cavity. As a result, the peak powers of about 9.5 and 13 W were obtained during the experiments, as well as in the numerical simulation.
Effects of nurses’ shiftwork characteristics and aspects of private life on work-life conflict
Authors: Oh Hye-Kyung , Cho Sung-Hyun 
Published: December 2020

Background
As nurses work highly irregular hours, the characteristics of shiftwork and aspects of their private lives are important factors that may contribute significantly to work-life conflict.

Purpose
This study examined the effects of nurses’ shiftwork characteristics and aspects of their private lives on work-life conflict.

Methods
The participants included 271 registered nurses working three-shift rotations in five types of units at four hospitals in South Korea. We distributed structured questionnaires regarding shiftwork characteristics, private life, and work-life conflict. Data were analyzed using multiple linear regression analysis.

Results
The significant factors relating to work-life conflict included control over shift start and finish times (β = -0.16, p = .019), frequency of swapping shifts with colleagues (β = 0.15, p = .025) among shiftwork characteristics, and leisure constraints (β = 0.39, p = < .001) in aspects of private life.

Conclusion
Plan and policies for improving nursing environments should focus on improving nurses’ control over shiftwork and decreasing leisure constraints.
Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation—A protocol for a randomized controlled pilot study
Authors: Bonfanti Nathaniel , Gundert Emily , Drewry Anne M. , Goff Kristina , Bedimo Roger , Kulstad Erik 
Published: December 2020

Background
Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever is typically treated (with antipyretics or directly with ice or other mechanical means), increasing data suggest that fever is a protective adaptive response that facilitates recovery from infectious illness.

Objective
To describe a randomized controlled pilot study of core warming patients with COVID-19 undergoing mechanical ventilation.

Methods
This prospective single-site randomized controlled pilot study will enroll 20 patients undergoing mechanical ventilation for respiratory failure due to COVID-19. Patients will be randomized 1:1 to standard-of-care or to receive core warming via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The primary outcome is patient viral load measured by lower respiratory tract sample. Secondary outcomes include severity of acute respiratory distress syndrome (as measured by PaO2/FiO2 ratio) 24, 48, and 72 hours after initiation of treatment, hospital and intensive care unit length of stay, duration of mechanical ventilation, and 30-day mortality.

Results
Resulting data will provide effect size estimates to guide a definitive multi-center randomized clinical trial. ClinicalTrials.gov registration number: NCT04426344.

Conclusions
With growing data to support clinical benefits of elevated temperature in infectious illness, this study will provide data to guide further understanding of the role of active temperature management in COVID-19 treatment and provide effect size estimates to power larger studies.
SOME RESULT OF NON-COPRIME GRAPH OF INTEGERS MODULO n GROUP FOR n A PRIME POWER
Authors: Masriani Masriani , Juliana Rina , Syarifudin Abdul Gazir , Wardhana I Gede Adhitya Wisnu , Irwansyah Irwansyah , Switrayni Ni Wayan 
Published: December 2020

One interesting topic in algebra and graph theory is a graph representation of a group, especially the representation of a group using a non-coprime graph. In this paper, we describe the non-coprime graph of integers modulo group and its subgroups, for is a prime power or is a product of two distinct primes.