bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Model of Subclinical Vitamin K Deficiency
Authors: Gancheva Silvia , Kitanova Martina , Ghenev Peter , Zhelyazkova-Savova Maria 
Published: June 2020

Introduction: Vitamin K (VK) is a co-factor in the post-translational gamma glutamic carboxylation of Gla-proteins. VK-dependent coagulation factors are carboxylated in the liver by VK1. Osteocalcin and Matrix-Gla protein (MGP) are carboxylated in extrahepatic tissues by VK2. A model of VK deficiency would be suitable for studying extrahepatic Gla-proteins provided that severe bleeding is prevented.
Aim: The aim of this work was to adapt an established protocol of vascular calcification by warfarin-induced inactivation of MGP as a calcification inhibitor, in an attempt to create a broader state of subclinical VK deficiency and to verify its safety.
Materials and methods: Two consecutive experiments, each lasting 4 weeks, were required to modify the dosing schedule of warfa&shy;rin and VK1 and to adapt it to the Wistar rats used. The original high doses of warfarin used initially had to be halved and the protective dose of VK1 to be doubled, in order to avoid treatment-induced hemorrhagic deaths. The second experiment aimed to confirm the efficacy and safety of the modified doses.
To verify the VK deficiency, blood vessels were examined histologically for calcium deposits and serum osteocalcin levels were mea&shy;sured.
Results: The original dosing schedule induced VK deficiency, manifested by arterial calcifications and dramatic changes in carboxyl&shy;ated and uncarboxylated osteocalcin. The modified dosing regimen caused similar vascular calcification and no bleeding.
Conclusion: The modified protocol of carefully balanced warfarin and VK1 doses is an effective and safe way to induce subclinical VK deficiency that can be implemented to investigate VK-dependent proteins like osteocalcin.
Evaluation of Non-polar Composition in Plumbago Zeylanica Leaves by Gas Chromatography and Mass Spectrometry
Authors: Dhalani Jayesh , Dubal Gaurang , Rathod Chirag , Nariya Pankaj 
Published: June 2020

Background:Plumbago zeylanica plant belongs to Plumbaginaceae. The plant is reported for many pharmacological activities.
Aim: The objective of the study was to identify fatty acids and non-polar chemical compounds in Plumbago zeylanica leaves.
Materials and methods: Petroleum ether extract was prepared using soxhlet apparatus. Saponifiable and unsaponifiable matter was separated with saponification process. To identify fatty acids in saponifiable matter further esterification was performed. Gas chromatography and mass spectrometry analysis was performed of both saponifiable and unsaponifiable fractions. All the fatty acid methyl esters and non-polar chemical compounds were identified using NIST library data.
Results: A total of 14 compounds were identified with comparison of NIST data. From that, 8 fatty acid methyl esters and 6 non-polar chemical compounds were identified. Here we have analyzed fatty acids and non-polar chemical compounds by the same GC-MS method.
Conclusions: The present analysis showed that Plumbago Zeylanica leaves contain 8 fatty acids and 6 non-polar chemical compounds. Principal determination of the research was development of efficient method to identify non-polar compound from plant by single injection using chromatographic technique.
Large-cell Neuroendocrine Carcinoma of the Endometrium in Myomatous Uterus
Authors: Shopov Spasimir T. , Anavi Benyamin L. , Krastev Dobrin K. 
Published: June 2020

Large-cell neuroendocrine carcinoma of the endometrium is an insufficiently researched aggressive tumor with a short survival regard&shy;less of the treatment type.
We present here the 38th consecutive case of literature reported cases of large cell neuroendocrine carcinoma of the endometrium (posi&shy;tive for synaptophysin, CD56, chromogranin A, p53, and Vimentin) found in the myomatous uterus of a 76-year-old woman.
We also describe in the study the morphological algorithm for differentiation of malignant blastomas with small (under 10 %) neuro-endocrinal component.
Accumulated clinical and morphological evidence raises the question whether the large-cell and the small-cell neuroendocrine carcino&shy;mas are just different variations according to their histology and topical occurrence (uterine body/cervix) or they are just independent forms with their respective clinical signs, morphology, treatment, and prognosis.
On-Board Video-Evaluation Algorithm of Transverse Safety Clearance for Ahead Road-Vehicle
Authors: Yashina Marina V. , Mokhov Alexey I. , Belova Maria A. , Kostsov Alexey V. , Pospelov Pavel I. 
Published: June 2020

<p class="0abstract">Traffic flows are becoming more intense over time as a result of global automobilization. Road transport specialists are developing and analyzing different approaches to control traffic, to design and to build new highways. Decreasing total amount of accidents and congestion avoidance on a road are the main goals of this research. General traffic flow features and car localization are the most important types of data to be obtained, processed and analyzed in modern conditions as cars are highly maneuverable. Proper usage of this data allows building new high-quality traffic control systems taking in account all of its significant features. We have developed a system for video-processing from camera fixed on car torpedo. Research presented in this paper suggests an algorithm of transverse safety clearance evaluation by analyzing a video from vehicle on-board camera.</p>
Le Peuple, la Terre et la notion d’appartenance dans Las Partidas
Authors: Ruiz Gómez Francisco 
Published: June 2020

L'ordonnancement politique des sociétés, tel que l'on expose dans Las Partidas, comprend trois éléments fondamentaux qui sont : le roi, le peuple et le royaume ou territoire qui leur appartiennent. En suivant les idées de la dénommée théologie politique, on affirme que le roi a le fief sur son peuple et son royaume en fonction d’un mandat divin. Les hommes, de leur côté, sont obligés à aimer Dieu, à obéir leurs rois et procurer le bien et la sauvegarde de leur terre, que dizen en latin patria. Le roi et le peuple forment un même corps politique, tandis que le territoire devient un lien commun à tous les deux. La terre est la référence basique pour l'encadrement politique des gens, elle est la mère du peuple, source de vie et de droit, et ils sont tous obligés pour cette raison à défendre leur terroir.
Cipriano de Valera et la traduction de la Bible en langue vernaculaire
Authors: Parello Vincent 
Published: June 2020

Cet article propose une réflexion sur la traduction de la Bible en langue vernaculaire à travers le cas de Cipriano de Valera, moine hiéronymite de Séville qui avait adhéré aux thèses réformées sous l’influence du docteur Egidio et de Constantino Ponce de la Fuente. Il se compose de trois parties : 1) Bible et traduction ; 2) Bible et lecture ; 3) Bible et canonicité. Pour Cipriano de Valera, le combat contre l’hérésie ne peut se faire que par une mise à la portée de tous de la Bible en langue vulgaire.
Importância do uso das tecnologias na prática pedagógica do educador
Authors: Sousa Adriana Santos , Santos Maria Carmo 
Published: June 2020

O uso de tecnologias na escola é entendido como um recurso para auxiliar o professor na integração dos conteúdos curriculares e inovadores para o fortalecimento da aprendizagem. O presente artigo tem como temática “A importância do uso de tecnologias na prática pedagógica do educador” e tem como objetivo geral analisar o uso das tecnologias na contribuição da aprendizagem. Este artigo nos convida a refletir sobre o uso das novas tecnologias no ensino aprendizado dos educandos e ainda repensar o papel do educador frente às inúmeros desafios que lhe é colocada, utilizar de forma criativa e inovadora os recursos tecnológicos como via de desenvolvimento de potenciais e de atividades necessárias para o desenvolvimento e de aprendizagem. Para a realização deste estudo, foram feitos entrevistas com alunos e professores para conhecer as práticas tecnológicas utilizadas em sala. Foi possível identificar que as maiorias dos educadores são favoráveis à mediação do aprendizado através das novas tecnologias, mas afirmam que existem inúmeros fatores que levam os mesmos a não utilizarem. A pesquisa realizada foi à pesquisa bibliográfica com autores que abordam sobre o tema escolhido e pesquisa de campo analisando o trabalho do educador e suas práticas pedagógicas. O uso da informática na educação implica em novas formas de comunicar, de pensar, de ensinar e aprender. O trabalho é fundamentado em uma pesquisa bibliográfica, a fundamentação se apoia em teóricos como Moran (2009), Freire, Fávero. Esses explicam qualitativa, acolhendo-se como método a pesquisa bibliográfica.
(Imagem de fancycrave1 por Pixabay)
Processo de individuação de Jung
Authors: Rocha Cleber Almeida 
Published: June 2020

Este estudo expõe o processo de individuação, que se trata da teoria do autodesenvolvimento na psicologia analítica de Jung. Para isso são apresentados alguns dos principais conceitos de Jung, sendo, anima e animus, sombra, complexo afetivo, persona, ego e Self ou Si-mesmo, visando proporcionar um contexto no qual esses conceitos se entrelaçam à individuação. Posteriormente, são expostas as conclusões das investigações de Jung a respeito da contribuição de outras abordagens para o desenvolvimento humano, sendo elas a alquimia e o cristianismo, assim como as limitações encontradas nessas abordagens segundo o pesquisador. Por fim é discutido a projeção da anima/animus e de uma persona de eficácia face a dinâmica das organizações contemporâneas, como um mecanismo de defesa do ego que precisam ser superados ou abandonados para permitir o livre fluxo do desenvolvimento do indivíduo. Sendo apresentada a análise de um filme e um caso a fim de elucidar o processo de projeção da anima e da persona.
(Imagem de eunyoung LEE por Pixabay)
Doenças tropicais negligenciadas na Amazônia e suas representações na grande imprensa escrita (1960-1980)
Authors: Aragon Sara Bello , Menezes Miguel Furtado , Inácio Filho Lourival 
Published: June 2020

Este artigo é resultado de uma análise histórico-cultural sobre as formas de abordagem da doença e seu enfrentamento na Amazônia, a partir da grande imprensa nacional entre as décadas de 1960 e 1980. Com ele, procura-se participar das discussões sobre as muitas imagens pelas quais estes veículos vêm construindo representações sobre a Amazônia a partir do recorte temporal elencado. Tem como enfoque central a questão das epidemias que transpuseram aspectos sociais, históricos e culturais sobre a região de um modo geral e sobre Rondônia de uma forma específica. O impacto social das Doenças Tropicais Negligenciadas no Brasil se caracterizava na Amazônia pelo avanço “espontâneo” e/ou incentivado de forma governamental, à custa da exploração humana e ambiental. Foram investigados três grandes veículos da imprensa brasileira: os jornais “Folha de São Paulo” e “O Globo”, bem como a revista “Veja” que passaram pela análise serial e de conteúdo, com análise estatística e ponderações qualitativas. O quadro teórico no qual esta pesquisa se inscreve é o dos estudos culturais e da História Cultural, anuindo singular importância à construção da imagem de local da insalubridade sobre a Amazônia que rivalizava com a representação de “Terra da Providência” presentes nas mesmas páginas periódicas.
(Image by Picography from Pixabay)
Responsabilidade civil das construtoras em caso de entrega das chaves do imóvel depois do prazo estabelecido no contrato de promessa de compra e venda
Authors: Sousa Samuel Monteiro , Lopes João Marcos Rocha , Barroso Ana Cláudia 
Published: June 2020

O presente trabalho tem o intuito de abordar os aspectos da responsabilidade civil, especificamente a responsabilidade civil voltada às construtoras pelo atraso da entrega de chaves, após o tempo aprazado em contrato de promessa de compra e venda. A pesquisa abordará conceitos gerais do instituto da responsabilidade civil para após verificar esses conceitos, no âmbito em geral aplicado expressamente a responsabilidade civil das construtoras ante ao atraso injustificado da entrega das chaves. A pesquisa foi baseada na técnica do estudo de caso, com análise doutrinária e jurisprudencial pátria. Foi utilizado o método dedutivo, de maneira que possibilitou esclarecer o posicionamento dos juristas acerca da matéria. O estudo levou a comprovação de que com as modificações no ordenamento pátrio, a responsabilidade civil das construtoras decorrente do atraso injustificado das chaves do imóvel, depois do prazo estabelecido em contrato de compra e venda.
(Imagem de Photo Mix por Pixabay)
The Use of Card Sort to Improve Students’ Vocabulary at MTsN Parepare
Authors: Afrianty Selvy 
Published: June 2020

This research aimed to know by using Card Sort can improve students’ vocabulary at students of MTsN Parepare. Generally the use of media as teaching aid mainly aimed at increasing the teaching process to be more motivating and interesting. This research was conducted in MTsN Parepare. Researcher used quantitative study in the form of Pre – Experimental design with one group pre-test and post-test. There are independent variable and dependent variable. Random sampling is the technique to take the sample and VIII.5 is the samples which consist with 26 students. The instrument that used is test, observation and documentation. The result calculation of mean score pre-test of students was 52.31 and mean score post- test of students was 65.57. The result of this research showed there was significant different in statistical analysis where the statistical t-test (2.7) was higher than t-table (1,708) with degree freedom (df = N-1) 25. The researcher concluded the using of Card Sort is able to improve students’ vocabulary. From 15 questionnaires, the students answered very positive. Based on the Likert scale, the students were very positive in learning English by using Card Sort. It means that the Card Sort media makes students have positive response toward in learning vocabulary. The cumulative percentage on the fifteen items of the positive statements questionnaire was 96,62, while the cumulative score that they got from the questionnaire was 1633. The researcher concluded the using of Card Sort is able to improve students’ vocabulary at MTsN Parepare
LITERASI PEMILIH PENYANDANG DISABILITAS: IDENTIFIKASI PERMASALAHAN DAN SOLUSINYA DI KABUPATEN SLEMAN
Authors: Viera Mayasari Sri Rengganis  
Published: June 2020

Penelitian ini bertujuan untuk mengetahui bagaimana kondisi literasi pemilih Penyandang Disabilitas, hambatan yang terjadi dalam pembentukan literasi pemilih tersebut, serta merekomendasikan sebuah desain kebijakan untuk membangun literasi pemilih Penyandang Disabilitas di Kabupaten Sleman. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif, dengan metode deskriptif. Fokus penelitian ini adalah program-program sosialisasi dan pendidikan pemilih yang telah dilakukan oleh KPU Kabupaten Sleman, serta program Pemerintah Kabupaten Sleman dalam rangka membentuk literasi pemilih Penyandang Disabilitas. Peneliti melakukan wawancara mendalam dengan Komisioner KPU Kabupaten Sleman dan perwakilan dari organisasi Penyandang Disabilitas. Selain itu dilakukan observasi terhadap kegiatan Perencanaan dan Proses Pembangunan Desa yang melibatkan komunitas Penyandang Disabilitas. Kesimpulan dalam penelitian ini berkaitan dengan 4 (empat) hal, yaitu: (1) Jika dilihat dari dimensi yang lebih luas yaitu literasi politik, maka Penyandang Disabilitas di Kabupaten Sleman belum memiliki literasi politik yang memadai; (2) Penyandang Disabilitas di Kabupaten Sleman masih terbatas memiliki pengetahuan tentang pemilu (literasi pemilih); (3) Hambatan yang ditemui dalam pembentukan literasi pemilih Penyandang Disabilitas utamanya karena ada diskriminasi dari keluarga, masyarakat dan pemerintah; (4) Proses pembentukan literasi pemilih diperoleh dari sosialisasi dan pendidikan pemilih yang dilakukan KPU Kabupaten Sleman. Rekomendasi yang bisa ditawarkan adalah: (1) Menciptakan regulasi yang mengatur sosialisasi dan pendidikan pemilih yang isinya tidak hanya terkait pemilihan umum; (2) Melakukan pendidikan politik dengan melibatkan keluarga Penyandang Disabilitas; (3) Mengoptimalkan konsep-konsep sosialisasi dan pendidikan pemilih dengan melibatkan Penyandang Disabilitas sebagai agen yang aktif; (4) Mengoptimalkan peranan SIPARMAS (Sistem Informasi Partisipasi Masyarakat).

Kata Kunci: literasi politik, literasi pemilih, sosialisasi dan pendidikan pemilih, Penyandang Disabilitas.
FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT MAHASISWA MEMILIH PERGURUAN TINGGI EKONOMI ISLAM (STUDI KASUS : STEI SEBI)
Authors: Fitriya Hadiyati , Yani Endang Ahmad 
Published: June 2020

Tujuan penelitian ini adalah untuk mengetahui faktor-faktor apa saja yang mempengaruhi minat tersebut, dan faktor apa saja yang paling dominan berpengaruh terhadap minat mahasiswa.Pengolahan data dalam penelitian ini menggunakan metode analisischi-square yang diolah melalui software SPSS 16.0 for windows.Berdasarkan penelitian tersebut diketahui bahwa nilai X2 hitung lebih lebih besar dari X2 tabel, sehingga terdapat hubungan antara indikator motivasi, keinginan mempelajari Ekonomi Islam, citacita menjadi ahli Ekonomi Islam, beasiswa dan citra kampus terhadap kepuasan minat mahasiswa. Setelah melakukan analisis terhadap data yang diperoleh dari responden, maka peneliti menyimpulkan bahwa faktor dominan yang memiliki hubungan denganminat mahasiswa adalah faktor promosi motivasi dan keinginan mempelajari Ekonomi Islam dengan nilai X2 hitung masing-masing 25,998 dan 25,287. Dari penelitian ini, dapat diperoleh informasi bahwa STEI SEBI sebagai lembaga pendidikan yang konsen dalam bidang Ekonomi Islam hendaknyadapat meningkatkan kualitas dalam kegiatan belajar dan mengajar, karena minat mahasiswa mempelajari ilmu Ekonomi Islam menjadi daya tarik utama disamping indikator lain seperti kesempatan mendapat beasiswa maupun citra kampus yang baik.Kata Kunci: Minat mahasiswa, perguruan tinggi Ekonomi IslamABSTRACThe purposes of this study determine the factor that influence these interest and what factors are the most dominance influence on student interest. Data processing in this study will use chi square analysis method that be processed through software SPSS 16.0 for windows. Based on in these studies was discovered that value of X2 count bigger than X2 Table, so there will correlation between indicator of motivation, desire to learn Islamic Economy, dream of being an expert in Islamic Economic, scholarship and college image toward the satisfaction of student interest. After conducting an analysis data from respondents, so researcher would concluded that the dominance factor which have related with student interest were the factor of motivation promotion and desire to learn Islamic Economic with value X2 count each 25.998 and 25.287. From this study, it can be obtained information that STEI SEBI as an educational institution concerned about Islamic Economic should improve quality in learning activities and teaching, because the interest of student to learn Islamic Economic science become main attraction beside other indicators such as opportunity to get a scholarship as well as better in campus image.Keyword : Student Interest, Islamic Economic College
KONSEP MARKETING MIX SYARIAH
Authors: Syukur Patah Abdul , Syahbudin Fahmi 
Published: June 2020

ABSTRAK. Pokok permasalahan yang akan dibahas dalam penulisan ini adalah konsep marketing mix yang sesuai dengan syariah. Penilaian konsep marketing mix yang sesuai syariah ini menilai variabel Product (Produk), Price (Harga), Place (Penempatan), dan Promotion (Promosi) dengan aturan-aturan muamalah dalam islam. Tujuan dari penelitian ini adalah untuk mengetahui dan menjelaskan konsep marketing mix syariah, serta sebagai kontribusi keilmuan berkaitan dengan marketing mix syariah. Teori yang digunakan dalam penelitian ini yaitu teori marketing, marketing mix, serta teori tentang muamalah yangsesuai dengan syariah. Penelitian ini memfokuskan pada penilaian marketing mix dengan aturan-aturan muamalah dalam islam. Metode yang digunakan dalam penelitian ini adalah kajian pustaka baik bersumber data buku ataupun jurnal, sedangkan untuk aspek penilaiannya yaitu ditinjau dari Al -Qur’an, Hadits, Ijtihad para ulama, dan karya ilmiah yang berkaitan dengan penelitian. Penelitian ini menghasilkan konsep marketing mix yang sesuai dengan syariah meliputi variabel Product (Produk), Price (Harga), Place (Penempatan), dan Promotion (Promosi) yang telah disesuaikan dengan aturan-aturan dalam muamalah islam, penelitian ini juga sebagai saran bagi para pelaku bisnis yang ingin menjalankan bisnisnya sesuai syariat Islam. Sehingga konsep marketing mix syariah ini memiliki perbedaan dengan marketing mix pada umumnya karena telah disesuaikan dengan aturan muamalah dalam islam.Kata kunci: marketing, marketing mix, marketing mix syariahABSTRACT. The main issues will be discussed in writing this is how theconcept of marketing mix according to sharia. Assessment the concept ofmarketing mix appropriate sharia this assess variable product, price, place, and promotion into rules muamalah in Islam. The purpose of this study is to find and explain the sharia marketing mix, and as a contribution scientific per taining to sharia marketing mix. A theory that used in this research that is the theory marketing, marketing mix, and a theory about muamalah in accordance with sharia. Methods used in this research is a literature study good sourced data book or journal , while on the aspect of this assessment that is in terms of the Al-Qur’an, Hadith, ijtihad ulama, and the work of scientific relating to the study.This research come up with concepts marketing mix according to shariacovering variable product, price, place, and promotion that has been adjusted for rules in Islamic him, the research also as a suggestion for actors businesses that would like to run business in accordance Islamic sharia. So that the concept of sharia marketing mix it has different to marketing mix in general because has been adjusted for rules him in Islam.Keywords: marketing, marketing mix, sharia marketing mix
Status and origin of Egyptian local rabbits in comparison with Spanish common rabbits using mitochondrial DNA sequence analysis
Authors: Emam Ahmed Mostafa , Afonso Sandra , González-Redondo Pedro , Mehaisen G.M.K. , Azoz A.A.A. , Ahmed N.A. , Fernand N. 
Published: June 2020

<p>Mitochondrial DNA (mtDNA) and cytochrome b (cyt b) gene sequences were used to determine the status of genetic diversity and phylogeny for 132 individuals from local rabbit breeds in Egypt and Spain. The Egyptian local rabbit breeds were Egyptian Red Baladi (ERB), Egyptian Black Baladi (EBB) and Egyptian Gabali Sinai (EGS). However, the Spanish local rabbit breed was Spanish common rabbit (SCR). Previous breeds were compared with European Wild Rabbit taken from Albacete, Spain (EWR). A total of 353 mutations, 290 polymorphic sites, 14 haplotypes, 0.06126 haplotype diversity and -1.900 (&lt;em&gt;P&lt;/em&gt;&lt;0.05) for Tajima’s D were defined in this study. Haplotype A mostly occurred in 83.3% of Egyptian rabbits and 11.7% of EWR, while haplotype B occurred in 63.8% of Spanish rabbits and 36.2% of the EGS breed. A total of 47 domestic and wild &lt;em&gt;Oryctolagus cuniculus&lt;/em&gt; published sequences were used to investigate the origin and relation among the rabbit breeds tested in this study. The most common haplotype (A) was combined with 44.7% of published sequences. However, haplotype B was combined with 8.5%. Haplotypes of Egyptian, SCR and EWR were scattered in cluster 1, while we found only one EGS haplotype with two haplotypes of EWR in cluster 2. Our results assumed that genetic diversity for ERB, EBB and SCR was very low. Egyptian breeds and SCR were introduced from European rabbits. We found that ERB and EBB belong to one breed.</p>