bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between non-alcoholic fatty liver disease-associated hepatic fibrosis and bone mineral density in postmenopausal women with type 2 diabetes or impaired glucose regulation
Authors: Zhu Xiaopeng , Yan Hongmei , Chang Xinxia , Xia Mingfeng , Zhang Linshan , Wang Liu , Sun Xiaoyang , Yang Xinyu , Gao Xin , Bian Hua 
Published: August 2020

IntroductionTo evaluate the association of non-alcoholic fatty liver disease (NAFLD)-associated hepatic fibrosis with bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM) or impaired glucose regulation (IGR).Research design and methodsTwo cohorts including 46 subjects with biopsy-proven NAFLD and 445 subjects with proton magnetic resonance spectrum-proven NAFLD were enrolled in this study. All subjects were postmenopausal women with T2DM or IGR. BMD at the lumbar spine L1–L4 and hip was measured using dual-energy X-ray absorptiometry. NAFLD fibrosis stage and NAFLD fibrosis score were used to evaluate the severity of liver fibrosis.ResultsIn subjects with liver biopsy-proven NAFLD, BMD (T-score, Z-score and BMD value) in the advanced fibrosis group were significantly lower than that in the non-advanced fibrosis group (p<0.05). Fibrosis stage was negatively associated with T-score, Z-score and BMD value after adjusting for age, body mass index (BMI) and fasting plasma glucose (FPG). Additionally, fibrosis stage was independently associated with T-score, Z-score and BMD value after adjusting for age, BMI and FPG. These results were validated in a large cohort of 445 subjects. Additionally, bone metabolism-associated factors, including calcium and phosphate, were associated with liver fibrosis, indicating that bone metabolism may play a critical role in the association between liver fibrosis and BMD. Mechanically, parathyroid hormone and biomarkers of bone formation (osteocalcin and procollagen type 1 N-terminal propeptide) and bone resorption (procollagen type I carboxy terminal peptide β special sequence) were increased in subjects with advanced liver fibrosis than in subjects without advanced liver fibrosis, indicating that liver fibrosis decreased BMD probably via increasing bone turnover.ConclusionsNAFLD-associated hepatic fibrosis was negatively associated with decreased BMD in postmenopausal women with T2DM or IGR. Liver fibrosis decreased BMD probably via increasing bone turnover. Severe liver fibrosis may represent high risk for osteoporosis in postmenopausal women with T2DM or IGR.
Estimating the proportion of overweight soldiers in the Australian Army by combat uniform waist size
Authors: Selman Jason , Zevenbergen M , Wing G 
Published: August 2020

IntroductionRecent studies have shown an increasing number of overweight and obese members serving in many armies. Overweight and obesity can be estimated using either body mass index or waist circumference measures. The aim of this research was to estimate the proportion of the Australian Army considered to be overweight and obese by waist circumference using the proxy measure of issued combat uniform waist size.MethodThe Australian Army has been progressively replacing combat uniforms with a new uniform design and camouflage pattern since 2016. The total number of issued combat uniforms by size was obtained from the points of issue for the three Australian Army combat brigades from the first issue of the new uniform in January 2016 through to November 2019. The waist size of issued combat pants was collated from each of the three points of issue, adjusted for measured waist size accuracy and sex, and analysed to estimate the proportion of overweight and obese soldiers in the Australian Army.ResultsThere were a total of 155 735 combat pants issued across the three points of issue. The mean waist size based on combat uniform pant size was found to be 90.4 cm, with an SD of 7.5 cm. Based on these data, approximately 23.3% of the Australian Army population can be estimated to be overweight and an additional 4.5% to be obese.ConclusionsThe Australian Army, like many western armies, has a significant proportion of overweight personnel. This can negatively affect operational capability, health and future healthcare costs both within the military and to society after military service has concluded. This is the first study to use a uniform waist size as a proxy to estimate overweight and obesity. This technique has application for the military, emergency services or any other organisation in which uniforms are provided.
Prevalence and temporal trends of presarcopenia metrics and related body composition measurements from the 1999 to 2006 NHANES
Authors: Li Ji-Bin , Wu Yuwan , Gu Dantong , Li Huajun , Zhang Xi 
Published: August 2020

ObjectiveTo evaluate the prevalence and temporal trends of presarcopenia and related body composition measurements.DesignCross-sectional study.SettingNational Health and Nutrition Examination Survey (NHANES) 1999–2006.MethodsPresarcopenia was defined according to the guidelines from the European Working Group on Sarcopenia. Logistic or linear regression models were used to evaluate the linear trend of the prevalence of presarcopenia, obesity and related body composition measurements.ParticipantsA total of 29 947 participants aged 18–90 years from five waves of the NHANES were included in the analysis.Outcome measuresPresarcopenia was sex-specifically defined as having a skeletal mass index ≤7.26 kg/m2 in men and ≤5.5 kg/m2 in women. Body composition measurements, including total body fat percentage, total body fat mass, total lean body mass, appendicular skeletal muscle mass and bone mineral density, were obtained by dual-energy X-ray absorptiometry.ResultsThe overall prevalence of presarcopenia ranged from 16.4% in 1999–2000 to 14.8% in 2005–2006 (p for trend=0.78). Presarcopenia was stable in both males (p for trend=0.36) and females (p for trend=0.20). The presarcopenia prevalence was significantly elevated among the age group of 18–39 years old (from 11.3% to 14.1%, p for trend=0.04) and among non-Hispanic blacks (p for trend <0.001). Adults aged ≥80 years old had the highest prevalence.ConclusionsThe prevalence of presarcopenia increased among young individuals over time. Non-Hispanic blacks also demonstrated an increasing trend in the prevalence over time.
Efficacy of biofeedback, repetitive transcranial magnetic stimulation and pelvic floor muscle training for female neurogenic bladder dysfunction after spinal cord injury: a study protocol for a randomised controlled trial
Authors: Xu Lin , Fu Chenying , Zhang Qing , Xiong Feng , Peng Lihong , Liang Zejun , Chen Li , He Chengqi , Wei Quan 
Published: August 2020

IntroductionNeurogenic bladder dysfunction is prevalent in female patients with spinal cord injury (SCI), and previous guidelines have recommended pelvic floor muscle training (PFMT) for first-line conservative treatment. However, the actual regimen of PFMT varies widely and the single treatment does not satisfy the need of some patients. Therefore, this study aims to provide a detailed rationale and methodology for comparing the effectiveness of PFMT, biofeedback and repetitive transcranial magnetic stimulation (rTMS) as adjunct treatments for neurogenic bladder dysfunction.Methods and analysisThis trial is a single-centre randomised controlled trial for female patients with urinary incontinence (UI) in phase of chronic SCI. Eligible participants will be randomised to one of four arms: (1) PFMT, (2) PFMT with biofeedback, (3) PFMT and rTMS and (4) PFMT with biofeedback and rTMS. There will be 44 participants in each arm and all the subjects will undergo 20 treatment sessions, five times a week for 4 weeks. The outcomes will be evaluated at 4 weeks, 3 months and 6 months after randomisation. The primary outcome is the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, and the secondary outcomes include bladder diary, pelvic floor muscle function and the International Spinal Cord Injury Quality of Life Basic Data Set.Ethics and disseminationThe Clinical Research and Biomedical Ethics Committee of the West China Hospital, Sichuan University has approved this trial and the approval number is 2019-885. All participants will be provided written informed consent after verification of the eligibility criteria. The results of this study will be accessible in peer-reviewed publications and be presented at academic conferences.Trial registration numberChinese Clinical Trial Registry (ChiCTR1900026126).
Incidence and risk factors of retinopathy of prematurity in Korle-Bu Teaching Hospital: a baseline prospective study
Authors: Braimah Imoro Zeba , Enweronu-Laryea Christabel , Sackey Adziri Harold , Kenu Ernest , Agyabeng Kofi , Ofori-Adjei Imelda-Odille Dziffa-Bella , Beyuo Vera , Oku Aaron , Essuman Vera Adobea 
Published: August 2020

ObjectiveTo determine the incidence of retinopathy of prematurity (ROP) and any associated risk factors among preterm infants at the Neonatal Intensive Care Unit (NICU) of Korle-Bu Teaching Hospital (KBTH).DesignProspective study.SettingLevel 3 NICU of KBTH from June 2018 to February 2019.ParticipantsEligible infants with birth weight (BW) less than 2 kg or gestational age (GA) less than 37 weeks were examined at scheduled intervals until full maturity of their retina.Outcome measuresThe primary outcome measure was cumulative incidence of ROP and secondary outcome measure was risk factors associated with ROP.ResultsOf the 401 infants, 222 were females (55.4%), mean±SD GA was 32.3±2.4 weeks (median 32, IQR 31 to 34) and mean BW 1.6±0.4 kg (median 1.5, IQR 1.3 to 1.9). The cumulative incidence of ROP was 13.7% (95% CI: 10.5 to 17.5%), with 1.8% (seven infants) having type 1 ROP. Increased risk of ROP was observed in babies with supplemental oxygen exposure (p<0.001), BW less than 1.5 kg (p=0.019), confirmed neonatal sepsis (p=0.001), nasogastric tube feeding (p=0.03) and poor pupillary dilation (0.032). A reduced risk of ROP was observed in boys (p=0.004) and after delivery by caesarean section (p=0.019).ConclusionThe rates of ROP at KBTH are comparable to other NICUs in sub-Saharan Africa. Birth weight less than 1.5 kg, confirmed neonatal sepsis, nasogastric tube feeding and poor pupil dilation were independently associated with increased incidence of ROP. ROP screening should be a part of the routine service for premature infants in Ghana.
Amyotrophic lateral sclerosis and the innate immune system: protocol for establishing a biobank and statistical analysis plan
Authors: Kjældgaard Anne-Lene , Pilely Katrine , Olsen Karsten Skovgaard , Lauritsen Anne Øberg , Pedersen Stephen Wørlich , Møller Kirsten , Garred Peter 
Published: August 2020

IntroductionAmyotrophic lateral sclerosis (ALS) is a devastating, progressive disease that causes degeneration of the motor neurons leading to paresis of the bulbar and the skeletal musculature. The pathogenesis of ALS remains unknown. We will test the hypothesis that the complement system is involved in the pathophysiology of ALS. This protocol article describes our efforts to establish a national Danish ALS biobank. The primary aim is to obtain biological material from patients with ALS for the current study as well as for future studies.Methods and analysisWe intend to establish an observational ALS biobank; some of the material from this biobank will be used for a prospective, observational case–control study. The participants are patients with ALS, neurologically healthy controls and non-ALS neurological controls. Each participant consents to be interviewed and to donate blood and cerebrospinal fluid to the biobank. Analysis of the complement system will be carried out on the three groups of patients and compared.Ethics and disseminationThe project has been approved by the Committees on Health Research Ethics in the Capital Region of Denmark (Approval number H-16017145) and the Danish Data Protection Agency (file number 2012-58-0004). All results will be published in peer-reviewed, medical journals and presented at scientific conferences.Trial registration numberNCT02869048
Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer
Authors: Crespo-Rodriguez Eva , Bergerhoff Katharina , Bozhanova Galabina , Foo Shane , Patin Emmanuel C , Whittock Harriet , Buus Richard , Haider Syed , Muirhead Gareth , Thway Khin , Newbold Kate , Coffin Robert S , Vile Richard G , Kim Dae , McLaughlin Martin , Melcher Alan A , Harrington Kevin J , Pedersen Malin 
Published: August 2020

BackgroundThe aggressive clinical behavior of poorly differentiated and anaplastic thyroid cancers (PDTC and ATC) has proven challenging to treat, and survival beyond a few months from diagnosis is rare. Although 30%–60% of these tumors contain mutations in the BRAF gene, inhibitors designed specifically to target oncogenic BRAF have shown limited and only short-lasting therapeutic benefits as single agents, thus highlighting the need for improved treatment strategies, including novel combinations.MethodsUsing a BRAFV600E-driven mouse model of ATC, we investigated the therapeutic efficacy of the combination of BRAF inhibition and oncolytic herpes simplex virus (oHSV). Analyses of samples from tumor-bearing mice were performed to immunologically characterize the effects of different treatments. These immune data were used to inform the incorporation of immune checkpoint inhibitors into triple combination therapies.ResultsWe characterized the immune landscape in vivo following BRAF inhibitor treatment and detected only modest immune changes. We, therefore, hypothesized that the addition of oncolytic virotherapy to BRAF inhibition in thyroid cancer would create a more favorable tumor immune microenvironment, boost the inflammatory status of tumors and improve BRAF inhibitor therapy. First, we showed that thyroid cancer cells were susceptible to infection with oHSV and that this process was associated with activation of the immune tumor microenvironment in vivo. Next, we showed improved therapeutic responses when combining oHSV and BRAF inhibition in vivo, although no synergistic effects were seen in vitro, further confirming that the dominant effect of oHSV in this context was likely immune-mediated. Importantly, both gene and protein expression data revealed an increase in activation of T cells and natural killer (NK) cells in the tumor in combination-treated samples. The benefit of combination oHSV and BRAF inhibitor therapy was abrogated when T cells or NK cells were depleted in vivo. In addition, we showed upregulation of PD-L1 and CTLA-4 following combined treatment and demonstrated that blockade of the PD-1/PD-L1 axis or CTLA-4 further improved combination therapy.ConclusionsThe combination of oHSV and BRAF inhibition significantly improved survival in a mouse model of ATC by enhancing immune-mediated antitumor effects, and triple combination therapies, including either PD-1 or CTLA-4 blockade, further improved therapy.
Plasma Biomarkers and Identification of Resilient Metabolic Disruptions in Patients With Venous Thromboembolism Using a Metabolic Systems Approach
Authors: Fraser Karl , Roy Nicole C. , Goumidi Louisa , Verdu Alexandre , Suchon Pierre , Leal-Valentim Felipe , Trégouët David-Alexandre , Morange Pierre-Emmanuel , Martin Jean-Charles 
Published: August 2020

Objective:
Deep vein thrombosis and pulmonary embolism referred as venous thromboembolism (VTE) are a common cause of morbidity and mortality. Plasma from healthy controls or individuals who have experienced a VTE were analyzed using metabolomics to characterize biomarkers and metabolic systems of patients with VTE.

Approach and Results:

Polar metabolite and lipidomic profiles from plasma collected 3 months after an incident VTE were obtained using liquid chromatography mass spectrometry. Fasting-state plasma samples from 42 patients with VTE and 42 healthy controls were measured. Plasma metabolomic profiling identified 512 metabolites forming 62 biological clusters. Multivariate analysis revealed a panel of 21 metabolites altogether capable of predicting VTE status with an area under the curve of 0.92 (
P
=0.00174, selectivity=0.857, sensitivity=0.971). Multiblock systems analysis revealed 25 of the 62 functional biological groups as significantly affected in the VTE group (
P
<0.05 to control). Complementary correlation network analysis of the dysregulated functions highlighted a subset of the lipidome composed mainly of n-3 long-chain polyunsaturated fatty acids within the predominant triglycerides as a potential regulator of the post-VTE event biological response, possibly controlling oxidative and inflammatory defence systems, and metabolic disorder associated dysregulations. Of interest was microbiota metabolites including trimethylamine N-oxide that remained associated to post incident VTE patients, highlighting a possible involvement of gut microbiota on VTE risk and relapse.

Conclusions:
These findings show promise for the elucidation of underlying mechanisms and the design of a diagnostic test to assess the likely efficacy of clinical care in patients with VTE.
Visual Symbols and Military Culture in Britain’s West African Colonial Army (c.1900–60)
Authors: Stapleton Timothy 
Published: August 2020

Abstract
Visual symbols like uniforms, emblems and ceremonies became central in inventing British military culture among West African forces reflecting orientalist and ornamentalist interpretations of empire. While uniforms fostered military identity, the versions devised for West African soldiers reproduced racial stereotypes and military fashion trends. Granting insignia and Colours to West African units transformed them from simplistic paramilitaries to honoured members of the British imperial milieu. Colours served as ritual objects enabling West African forces to recreate pivotal cultural events of the British regimental system. The public presence of uniformed West African soldiers promoted a sense of imperial majesty that reinforced British rule. Travelling to Britain, West African troops participated in parades and exhibitions initially displaying the epic scale of the empire, but eventually these military visitors became symbols of colonial reform. With independence, Britain’s former colonies in West Africa retained Western-style military symbols altered to highlight republicanism and modernist aspirations.
Predicting Successful Laparoendoscopic Transhiatal Esophagectomy (THE) by Mediastinal Height Measurement
Authors: Monnett Shane Wylie , Tsai Jonathon Yu-Lin , Austin Jeffrey Daniel , Harmon Cameron Martin , Shapiro Jacob Ian , Calderwood Lisa Christine , Thompson Stephanie , Martinez Maria Alejandra , Tiley Edward Henry , Richmond Bryan Kelly , Clanton Jesse Allen 
Published: August 2020

Background Laparoendoscopic transhiatal esophagectomy (THE) provides advantages over traditional THE by not only avoiding laparotomy but by also allowing more precise esophageal mobilization. Occasionally, the length of the gastric conduit is insufficient to allow delivery into the neck after laparoscopic mobilization and requires laparotomy to complete the procedure. We hypothesize that the need for laparotomy will correlate with the measurement of mediastinal height (distance from thoracic vertebrae T1-T12) on chest CT. Methods Medical records of all patients who underwent attempted laparoendoscopic-assisted THE at a tertiary referral center between March 1, 2003 and January 31, 2019 were reviewed. Patients’ mediastinal height was measured using computed tomography (CT) imaging of the chest by investigators and analyzed for correlation between mediastinal height and successful completion of a totally laparoendoscopic procedure. Results A total of 21 cases met inclusion criteria: 9 successful laparoendoscopic THE procedures and 12 failed laparoendoscopic THE procedures (those requiring addition of a mini-laparotomy or thoracotomy). The mean mediastinal length for successful laparoendoscopic surgery was 23.5 cm, whereas the mean mediastinal length for failed laparoscopic surgeries was 24.8 cm (P = .03). Patient’s overall height was not found to correlate with the need for conversion. Conclusions Shorter mediastinal length is associated with successful laparoendoscopic or laparoscopic THE. This information is readily available to clinicians from routine preoperative staging studies (chest CT) and may be used to potentially predict the success rate of a totally laparoendoscopic approach and aid in patient selection. Further prospective evaluation of these findings is warranted.
Femoral histomorphometric age-at-death studies: The issue of sample size and standard error
Authors: Maggio Ariane , Franklin Daniel 
Published: August 2020

Extant histomorphometric aging methods based on the analysis of the femoral cortex generally report small samples ( N<100) and highly variable standard error of the estimate (SEE) values (±1.51‒16.98 years). The present paper reviews the published literature on femoral histomorphometry for age-at-death estimation in order to examine the relationship between sample size and SEE values, and makes recommendations for minimum reporting requirements for age-at-death studies based on statistical data. The SEE from a total of 33 studies are analysed. Sample size and confidence intervals are explored using Hennig and Cooper’s simulation modelling. Analysis of effect size through a fixed-effect model is performed on 5/33 studies to examine the relationship between sample size and effect size. The pooled sex formulae from Nor et al., Martrille et al. and Thompson and the two sex-specific formulae of Pfeiffer are examined, as they report mean and standard deviation values for both chronological and estimated ages. The results of these analyses support sampling theory, specifically wide variation in SEE when N<100, narrowing as the sample size increases, and lower effect sizes in the larger of the five studies examined. The findings provide some support for a minimum threshold of 100‒150 individuals for histomorphometric age-at-death estimation. Analysis of effect size is suggested for future investigation in meta-analyses of forensic anthropological age-estimation studies. To ensure increased precision and meaningful comparison, large samples should be used for histomorphometry, and authors should report SEE and discrete statistics (e.g. n, mean, standard deviation) for both chronological age and estimated age.
CT Diagnosis of the Fracture of Anterior Nasal Spine
Authors: You Tingting , Meng Yanjie , Wang Yonghua , Chen Haisong 
Published: August 2020

Objective: To study anterior nasal spine fractures, including the incidence, missed diagnosis rates, and relationship with shapes using computed tomography (CT). Methods: Two hundred cases of axial CT images performed for maxillofacial trauma were reviewed. The incidence, correct, and missed diagnosis rates of anterior nasal spine fractures were studied. The relationship between the fracture and the shape of the anterior nasal spine was also analyzed. Results: The rate of anterior nasal spine fractures was 22.00% (44 of 200). The diagnostic accuracy was 4.55% (2 of 44) and the missed diagnosis rate was 95.45% (42 of 44). The fracture rates of the double rod, single rod, triangle, and irregular anterior nasal spine were 33.85% (22 of 65), 32.26% (10 of 31), 12.24% (12 of 98), and 0.00% (0 of 6), respectively. The double and single rod types of anterior nasal spine were most likely to be fractured than the type of triangle (χ2 = 11.05, 6.67, P < .0167). No fracture was found in the irregular type of anterior nasal spine. Conclusion: Anterior nasal spine fractures are not rare and the high missed diagnostic rate results from unfamiliarity with the structure. Double and single rod types of anterior nasal spines are easy to fracture. Bony reconstruction and thin thickness of CT images are necessary for diagnosis.