bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes
Authors: Esmaeili Sajjad , Ghobadi Nazanin , Nazari Donya , Pourhossein Alireza , Rasouli Hassan , Adibi Hadi , Khodarahmi Reza 
Published: May 2020

Background:
Curcumin, as the substantial constituent of the turmeric plant (Curcuma longa),
plays a significant role in the prevention of various diseases, including diabetes. It possesses ideal structure
features as an enzyme inhibitor, including a flexible backbone, hydrophobic nature, and several
available hydrogen bond (H-bond) donors and acceptors.

Objective:
The present study aimed at synthesizing several novel curcumin derivatives and further
evaluation of these compounds for possible antioxidant and anti-diabetic properties along with inhibitory
effect against two carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase, as these enzymes
are therapeutic targets for attenuation of postprandial hyperglycemia.

Methods:
Therefore, curcumin-based pyrido[2,3-d]pyrimidine derivatives were synthesized and identified
using an instrumental technique like NMR spectroscopy and then screened for antioxidant and enzyme
inhibitory potential. Total antioxidant activity, reducing power assay and 1,1-diphenyl-2-
picrylhydrazyl (DPPH•) radical scavenging activity were done to appraise the antioxidant potential of
these compounds in vitro.

Results:
Compounds L6-L9 showed higher antioxidant activity while L4, L9, L12 and especially L8
exhibited the best selectivity index (lowest α-amylase/α-glucosidase inhibition ratio).

Conclusion:
These antioxidant inhibitors may be potential anti-diabetic drugs, not only to reduce glycemic
index but also to limit the activity of the major reactive oxygen species (ROS) producing pathways.
Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors
Authors: Vázquez-Jiménez Lenci Karina , Paz-González Alma Delia , Juárez-Saldivar Alfredo , Uhrig María Laura , Agusti Rosalía , Reyes-Arellano Alicia , Nogueda-Torres Benjamín , Rivera Gildardo 
Published: May 2020

Background:
Chagas disease, caused by the parasite Trypanosoma cruzi represents a worldwide epidemiological, economic, and
social problem. In the last decades, the trans-sialidase enzyme of Trypanosoma cruzi has been considered an attractive target for the
development of new agents with potential trypanocidal activity.

Objective:
In this work, the aim was find new potential non-sugar trans-sialidase inhibitors using benzoic acid as a scaffold.

Method:
A structure-based virtual screening of the ZINC15 database was carried out. Additionally, the enzyme and trypanocidal activity of
the selected compounds was determined.

Results:
The results of this work detected 487 compounds derived from benzoic acid as potential transsialidase
inhibitors with a more promising binding energy value (< -7.7 kcal/mol) than the known inhibitor
2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA). In particular, two lead compounds, V1 and
V2, turned out to be promising trans-sialidase inhibitors. Even though the trypanocidal activity displayed
was low, these compounds showed trans-sialidase inhibition values of 87.6% and 29.6%, respectively.

Conclusion:
Structure-based virtual screening using a molecular docking approach is a useful method for the identification of new transsialidase inhibitors.
Sacubitril-Valsartan Improves Anemia of Cardiorenal Syndrome (CRS)
Authors: Robles Nicolás R. , Campillejo Rosa D. , Valladares Julian , de Vinuesa Elena G. , Villa Juan , Gervasini Guillermo 
Published: May 2020

Background and Aims:
Anemia is a common complication of heart failure and Chronic
Kidney Disease (CKD). Sacubitril-valsartan is a novel therapy for the treatment of chronic Heart
Failure with a reduced Ejection Fraction (HFrEF). We have evaluated the short-term effects of sacubitril-
valsartan on the anemia of CRS.

Methods:
The study group comprised 39 patients with HFrEF, who were followed-up for three
months. The study is a retrospective analysis of clinical data. Data of 3 months’ and baseline visits
were recorded including plasmatic creatinine, glomerular filtration rate, cystatin C, kaliemia, haemoglobin,
pro-BNP, and albuminuria.

Results:
In all, 34 patients ended the follow-up. Mean sacubitril-valsartan dosage at baseline was 101
± 62 mg/day and 126 ± 59 mg/day at end. Mean hemoglobin increased from 12.2 ± 1.1 g/dl at baseline
to 12.9 ± 1.0 g/dl (p = 0.001,). Prevalence of anemia was 64.7% (95%CI, 47.9-78.5%) at baseline
and 38.4 (95%CI, 23.9-55.0%) after the follow-up (p = 0.016). Serum cystatin C levels decreased
from 2.71 ± 1.0 to 2.48 ± 1.0 mg/l (p = 0.028). Serum K levels remained unchanged (baseline
4.94 ± 0.60, three months visit 4.94 ± 0.61 mmol/l, p = 0.998).

Conclusions:
Sacubitril-valsartan improves anemia in CRS patients. An improvement in serum cystatin
levels was observed. Few untoward effects were detected. These findings should be confirmed in
wider clinical trials.
Persepsi Dan Minat Masyarkat Terhadap Asuransi Syariah Di Kabupaten Tangerang
Authors: Khumaini Sabik , Husein Muh Turizal 
Published: May 2020

<p align="center"><strong><em>Abstract</em></strong><strong></strong></p><p>Islamic insurance is an effort to protect each other and help among a number of people through investments in the form of assets or <em>tabarru</em> 'which provide a pattern of taking to face certain risks or dangers through a contract that is in accordance with sharia. This study aims to determine and analyze people's perceptions and interests in Islamic insurance in Tangerang Region.</p><p>The sampling technique uses purposive sampling method. The data used are primary data obtained based on respondents' answers to the questionnaire given. This study uses multiple linear regression analysis methods with the classic assumption test, descriptive analysis, t test (partial), F test (simultaneously), and coefficient test.</p><p>The results showed that partially the perception and interest variables of the community had a significant positive effect on islamic insurance. Furthermore, simultaneously the perception variable, and community interest have a significant positive effect on islamic insurance in Tangerang Region with a level of significance of less than 5%.</p><p><strong><em>Keywords</em></strong><strong>: </strong><em>insurance, Islamic, perception, interest</em></p><p align="center"><strong>Abstrak</strong></p><p>Asuransi syariah adalah usaha untuk saling melindungi dan tolong menolong diantara sejumlah orang yang melalui investasi dalam bentuk aset atau tabarru’ yang memberikan pola pengambilan untuk menghadapi risiko atau bahaya tertentu melalui akad yang sesuai dengan syariah. Penelitian ini bertujuan untuk mengetahui dan menganalisis persepsi dan minat masyarakat terhadap asuransi syariah di Kabupaten Tangerang.</p><p>Teknik pengambilan sampel menggunakan metode <em>purposive sampling</em>. Data yang digunakan adalah data primer yang diperoleh berdasarkan jawaban responden terhadap kuesioner yang diberikan. Penelitian ini menggunakan metode analisis regresi linier berganda dengan uji asumsi klasik, analisis deskriptif, uji t (secara parsial), uji F (secara simultan), dan uji koefisien. </p><p>Hasil penelitian menunjukkan bahwa secara parsial variabel persepsi dan minat masyarakat berpengaruh positif signifikan terhadap asuransi syariah. Selanjutnya, secara simultan variabel persepsi, dan minat masyarakat berpengaruh positif signifikan terhadap asuransi syariah di Kabupaten Tangerang dengan <em>level of significance</em> kurang dari 5%.</p><p><strong>Kata kunci:</strong> <em>Asuransi, Syariah, Persepsi, Minat</em></p>
Meta-analysis of immunogenicity and safety of human rabies vaccination under Zagreb and Essen regimens
Authors: Li Ting , Wang Xin , Cheng Hongbin 
Published: May 2020

Aim:
To assess the immunogenicity and safety of rabies vaccination under the Zagreb and Essen regimens by performing a meta-analysis.
Methods:
Electronic databases were searched for eligible studies. Risk ratios and weighted mean differences with 95% CIs were used to calculate estimates.
Results:
A total of 18 studies were included. Rabies virus neutralizing antibody concentration was comparable between the two regimens at D7 and 14. No significant differences were observed in seroconversion rates from D14 and 42. Incidence of fever was higher in Zagreb group (risk ratio: 1.55 [1.37–1.76]); but no significant differences were present for other common adverse events.
Conclusion:
Rabies vaccination under the Zagreb regimen was noninferior to the Essen regimen in immunogenicity and had an acceptable safety profile.
CORPORATE GOVERNANCE, DISCLOSURE DAN GENERAL EQUILIBRIUM TERHADAP ASYMMETRY INFORMATION - PERSPEKTIF EKONOMI MIKRO DAN PERSPEKTIF AKUNTANSI
Authors: Hayati Nur 
Published: May 2020

Paper ini merupakan review literatur tentang topik empiris terkait Corporate Governance, Disclosure dan General Equilibrium terhadap Asymmetry Information Perspektif Ekonomi Mikro dan Perspektif Akuntansi. Penulis mengambil tema tersebut dilatarbelakangi adanya fenomena isu Asymmetry Information yang berkembang pada pasar persaingan tidak sempurna sehingga yang terjadi pasar gagal dalam memproduksi hasil yang efisien dan tidak bisa menjelaskan berbagai kondisi teoritis yang dibutuhkan bagi suatu pasar dengan persaingan sempurna. George Akerlof menggunakan istilah informasi asimetris dalam karyanya tahun 1970an disebut The Market for Lemons. Akerlof menyadari bahwa dalam pasar seperti itu, nilai rata-rata dari komoditas cenderung lebih menurun, bahkan untuk kualitas yang sangat sempurna kebalikannya, karena para pembeli tidak mempunyai cara untuk mengetahui apakah produk yang mereka beli akan menjadi sebuah “lemon” (produk yang menyesatkan). Dapat dikatakan bahwa penjual lebih tahu daripada pembeli sehingga muncullah teori ketidakpastian kualitas.
Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease
Authors: Kytikova O. Yu. , Novgorodtseva T. P. , Denisenko Yu. K. , Kovalevsky D. A. 
Published: May 2020

Aim. To present literature data on the metabolic and genetic mechanisms of impaired fatty acid (FA) synthesis in the development and progression of non-alcoholic fatty liver disease (NAFLD).General findings. NAFLD is a widespread disease progressing from steatosis to non-alcoholic steatohepatitis (NASH), increasing the risk of cirrhosis, liver failure and hepatocellular carcinoma. Progression of NAFLD and the development of NASH are closely related to lipid metabolism disorders caused not only by insufficient alimentary intake of fatty acids, but also by a decrease in the efficiency of their endogenous processing. The regulation of fatty acid metabolism involves enzymes desaturase (FADS1, FADS2) and elongase (ELOVL2 and ELOVL5) fatty acids. Desaturases are encoded by the FADS1 and FADS2 genes for fatty acid desaturases. Polymorphisms in the genes of fatty acid desaturases determine the effectiveness of PUFA endogenous processing. Violations in the activity of FADS1 and FADS2 and their genes are accompanied by dysregulation of the metabolic pathway involved in the biosynthesis of fatty acids. This leads to the damage of cell membranes, whose main components are represented by phospholipids. The progression of NAFLD is associated with the powerful toxicity of lipids released in the liver parenchyma upon the loss of the cell biomembrane integrity.Conclusions. Further research into the NAFLD genetic mechanisms regulating the metabolism of fatty acids appears to be promising for a deeper understanding of the pathogenesis of this multifactorial disease.
New Prospects of Cytoprotection in the Treatment and Prevention of Gastric and Intestinal Diseases (Resolution of an Expert Council and Literature Review)
Authors: Martynov A. I. , Sheptulin A. A. , Mayev I. V. , Kazyulin A. N. , Karateev A. Ye. , Melekhov A. V. , Pal’gova L. K. , Raikhel’son K. L. 
Published: May 2020

Aim. To generalize up-to-date information on the possibilities of cytoprotection in the treatment and prevention of gastric and intestinal diseases, as well as to present the materials of an Expert Council meeting held on February 8, 2020 in Moscow under the support of the Alium company.General provisions. The conducted Expert Council meeting was aimed at discussing the importance of improving the cytoprotective properties of the gastric and intestinal mucous membrane in the treatment of its lesions. It was shown that Rebamipide exhibits positive effects on various parts of the protective barrier of the gastrointestinal tract (GIT), primarily due to its stimulating action on the production of prostaglandins playing a key role in maintaining the cytoprotective properties of the gastrointestinal mucosa. The possibilities of applying Rebamipide for the treatment and prevention of erosive and ulcerative gastrointestinal lesions caused by non-steroidal anti-inflammatory (NSAIDs) and antithrombotic drugs were demonstrated. In the treatment of gastroesophageal reflux disease, Rebamipide is recommended for patients refractory to therapy with proton pump inhibitors (PPIs) and for those with non-acid reflux. The efficacy of Rebamipide in the treatment of Helicobacter pylori (H. pylori) infection, as well as functional dyspepsia and chronic gastritis, was confirmed.Conclusions. Rebamipid is a highly effective drug positively affecting various cytoprotection links, thus being suitable for the treatment and prevention of erosive and ulcerative lesions of the gastrointestinal tract, as well as gastroenterological diseases of various etiologies.Conflict of interest: The Expert Council meeting was supported by the Alium company.
Resultan Sistem Pemilu dan Sistem Pemerintahan terhadap Pelaksanaan Demokrasi di Indonesia
Authors: Mahanani Anajeng Esri Edhi 
Published: May 2020

Problems related to the resultant electoral system and the government system are the focus of the discussion in this study. Types of electoral systems, as well as types of governmental systems are discussed to be able to be a study of the use of electoral systems and government systems. The purpose of discussing this problem is to analyze the electoral system and the government system that are compatible with the implementation of democracy in Indonesia. This research is discussed through normative analysis, and through qualitative methods. The results of the qualitative normative analysis can be seen as follows: First, the results of the analysis show that there is a resultant between the electoral system towards the implementation of democracy in Indonesia as seen from the theory of the people's unity and the representative system. The consultant becomes strong if the general election system used is a purely open proportional electoral system, namely the voter as the supreme sovereignty constitution, can know with certainty who the candidate is and will help determine who is the people's representative. Second, there is a result between the government system and the implementation of democracy, the theory of popular sovereignty and the system of representation. Parliamentary and presidential government systems have their own weak points and strengths. However, the presidential system applied in democratic countries in Indonesia is better, because it tends to be more stable in its accountability. Placing the highest sovereignty as the only party that accepts the responsibility of those who have been elected to the executive and parliamentary institutions. The concept developed is a system of political representation, not as a system of partisan representation .

Keywords: Resultan, District System, Proporsional System, Presidensiil, Parlementary
Presupuesto Participativo en la ciudad de La Plata 2015-2019
Authors: Piana Ricardo Sebastián , Furnari Diego Martín 
Published: May 2020

El presente trabajo pretende analizar el resultado del presupuesto participativo, en el período 2015-2019, en el municipio de La Plata. Este tipo de políticas, enmarcada hoy en las prácticas del gobierno abierto, se presentaron como uno de los ejes de campaña para Cambiemos (en los niveles nacional, provincial y municipal). Se propuso generar las condiciones necesarias para "abrir el Estado" a la participación individual a la vez que desmovilizar a la ciudadanía.
La ciudad de La Plata fue un experimento de este tipo de políticas, donde el presupuesto participativo se presentó como una de las propuestas de campaña a pesar de contar con una larga experiencia en presupuesto participativo.
¿Cuáles fueron discursos, cuáles las políticas impulsadas y cuáles los resultados? Tal como se indicará en el artículo, un discurso antipolítico propició generar nuevos mecanismos participativos tecnológicos que desarmaron los espacios comunes ya existentes para la discusión del presupuesto participativo. La falta de información, discontinuidad y desinterés por generar nuevos espacios deliberativos por la gestión Cambiemos en la ciudad de La Plata han marcado una involución de las políticas de presupuesto participativo hasta entonces existentes.
El reflejo de los sentimientos. Volver como síntesis narrativa y estética en la obra de Pedro Almodóvar
Authors: Montesinos Soudry Pablo 
Published: May 2020

La obra cinematográfica de Pedro Almodóvar ha experimentado una gran evolución, que tiene que ver, sobre todo, con un mayor dominio de la narrativa cinematográfica y un progresivo refinamiento de la estética. Y sin embargo, se puede señalar claramente una serie de temas, personajes, rasgos narrativos y estéticos comunes y constantes en la filmografía del director manchego. Todos ellos se encuentran presentes en su película Volver (To Retun, 2006), que resulta un compendio y una reelaboración del imaginario y de los referentes temáticos repetidos a lo largo de toda su filmografía, y, sobre todo, una culminación de las pautas narrativas y estéticas definitorias de su obra. Esta película será utilizada como instrumento de privilegio para evaluar cómo los responsables de la fotografía, el vestuario y el diseño de producción trabajan bajo las órdenes del director para lograr unos resultados tan específicos de este autor.Palabras clave: Pedro Almodóvar; Volver; rasgos estéticos; pautas narrativas Key words: Pedro Almodóvar; To Retun; aesthetic features; narrative patterns
La naturaleza metafílmica de Los abrazos rotos
Authors: Melendo Ana 
Published: May 2020

El artículo profundiza en las señas escriturales marcadas por la autorreferencialidad y la autorreflexión diseñadas a partir, entre otras cuestiones, de la recurrencia al uso de material cinematográfico como fuente de inspiración que se dan cita en Los abrazos rotos; y cómo Almodóvar encuentra un método eficaz en el metacine para meditar y teorizar sobre la imagen y su evolución activando con esa finalidad los mecanismos necesarios que le permiten bucear en un territorio afín que se viene denominando poscine, un territorio en el que el artista demuestra, una vez más, su innegable amor hacia el arte y la imagen cinematográfica, reaccionando ante esa pulsión metaficcional que lleva al cine a volverse sobre sí mismo para pensar sobre sus propios medios expresivos. Palabras clave: metacine; poscine; metaficcional; autorreferencialidad; autorreflexión.Keywords: metafilm; post-cinema; metafictional; self-referentiality; self-reflection.
El drama pasional de la mujer investigadora. Un arquetipo femenino de la crisis
Authors: Antón Laura 
Published: May 2020

En este artículo se estudia la narrativa audiovisual de la mujer investigadora. En la historia del cine, la presencia de este arquetipo femenino se ha fortalecido especialmente en periodos de crisis del relato de la Historia, y puede leerse como un trayecto de búsqueda hacia otra identidad femenina. Con el fin de plantear algunas de las claves más significativas de su imaginario audiovisual se realiza un breve análisis del trayecto histórico de este arquetipo. Siguiendo el método del análisis textual, se presentan como casos de análisis un relato informativo y tres textos audiovisuales: el episodio “Piloto” de la serie televisiva Homeland (M. Cuesta, 2011), El silencio de los corderos (J. Demme, 1991) y Recuerda (A. Hitchcock, 1945). En estos tres textos, la configuración del drama pasional toma como vehículo de expresión la mirada femenina. Esta mirada pasional hacia un objeto de deseo (investigación), que atrae y a la vez inquieta, expresa la crisis de la subjetividad femenina con la que se inicia un inestable y peligroso trayecto de investigación hacia otra identidad, distinta a la habitual en el discurso institucional sobre “la mujer”.Palabras clave: narrativa audiovisual; mujer investigadora; drama pasional; neonoir, identidad; postmodernidad. Keywords: audiovisual narrative; female investigator, passionate drama, neonoir, identity, postmodernism.
Ángel Fuentes y su legado en la preservación del patrimonio fotográfico
Authors: Riego Amézaga Bernardo 
Published: May 2020

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