bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway
Authors: Wang Mengxiong , Law Mary E. , Davis Bradley J. , Yaaghubi Elham , Ghilardi Amanda F. , Ferreira Renan B. , Chiang Chi-Wu , Guryanova Olga A. , Kopinke Daniel , Heldermon Coy D. , Castellano Ronald K. , Law Brian K. 
Published: December 2019

AbstractDisulfide bond-disrupting agents (DDAs) are a new chemical class of agents recently shown to have activity against breast tumors in animal models. Blockade of tumor growth is associated with downregulation of EGFR, HER2, and HER3 and reduced Akt phosphorylation, as well as the induction of endoplasmic reticulum stress. However, it is not known how DDAs trigger cancer cell death without affecting nontransformed cells. As demonstrated here, DDAs are the first compounds identified that upregulate the TRAIL receptor DR5 through transcriptional and post-transcriptional mechanisms to activate the extrinsic cell death pathway. At the protein level, DDAs alter DR5 disulfide bonding to increase steady-state DR5 levels and oligomerization, leading to downstream caspase 8 and 3 activation. DDAs and TRAIL synergize to kill cancer cells and are cytotoxic to HER2+ cancer cells with acquired resistance to the EGFR/HER2 tyrosine kinase inhibitor Lapatinib. Investigation of the mechanisms responsible for DDA selectivity for cancer cells reveals that DDA-induced upregulation of DR5 is enhanced in the context of EGFR overexpression. DDA-induced cytotoxicity is strongly amplified by MYC overexpression. This is consistent with the known potentiation of TRAIL-mediated cell death by MYC. Together, the results demonstrate selective DDA lethality against oncogene-transformed cells, DDA-mediated DR5 upregulation, and protein stabilization, and that DDAs have activity against drug-resistant cancer cells. Our results indicate that DDAs are unique in causing DR5 accumulation and oligomerization and inducing downstream caspase activation and cancer cell death through mechanisms involving altered DR5 disulfide bonding. DDAs thus represent a new therapeutic approach to cancer therapy.
Multi-cell Monte Carlo method for phase prediction
Authors: Niu Changning , Rao You , Windl Wolfgang , Ghazisaeidi Maryam 
Published: December 2019

AbstractWe propose a Multi-Cell Monte Carlo algorithm, or (MC)$${}^{2}$$2, for predicting stable phases in chemically complex crystalline systems. This algorithm takes advantage of multiple cells to represent possible phases, while eliminating the size and concentration restrictions in the previous counterparts. Free atomic transfer among cells is achieved via the application of the lever rule, where an assigned molar ratio virtually controls the percentage of each cell in the overall simulation, making (MC)$${}^{2}$$2 the first successful algorithm for simulating phase coexistence in crystalline solids. During the application of this method, all energies are directly computed via density functional theory calculations. We test the method by successful prediction of the stable phases of known binary systems. We then apply the method to a quaternary high-entropy alloy. The method is particularly powerful in predicting stable phases of multicomponent systems, for which phase diagrams do not exist.
Topological electronic states in HfRuP family superconductors
Authors: Qian Yuting , Nie Simin , Yi Changjiang , Kong Lingyuan , Fang Chen , Qian Tian , Ding Hong , Shi Youguo , Wang Zhijun , Weng Hongming , Fang Zhong 
Published: December 2019

AbstractBased on the first-principles calculations and experimental measurements, we report that the hexagonal phase of ternary transition metal pnictides TT’X (T=Zr, Hf; T’=Ru; X=P, As), which are well-known noncentrosymmetric superconductors with relatively high transition temperatures, host nontrivial bulk topology. Before the superconducting phase transition, we find that HfRuP belongs to a Weyl semimetal phase with 12 pairs of type-II Weyl points, while ZrRuAs, ZrRuP and HfRuAs belong to a topological crystalline insulating phase with trivial Fu-Kane $${{\mathbb{Z}}}_{2}$$

Z

2

indices but nontrivial mirror Chern numbers. High-quality single crystal samples of the noncentrosymmetric superconductors with these two different topological states have been obtained and the superconductivity is verified experimentally. The wide-range band structures of ZrRuAs have been identified by ARPES and reproduced by theoretical calculations. Combined with intrinsic superconductivity, the nontrivial topology of the normal state may generate unconventional superconductivity in both bulk and surfaces. Our findings could largely inspire the experimental searching for possible topological superconductivity in these compounds.
Synthesis and degradation kinetics of TiO2/GO composites with highly efficient activity for adsorption and photocatalytic degradation of MB
Authors: Wang Ruifen , Shi Kaixuan , Huang Dong , Zhang Jing , An Shengli 
Published: December 2019

AbstractPoriferous TiO2/GO (denoted as TGO-x%) photocatalysts with ultrathin grapheme oxide (GO) layer were prepared by a hydrothermal method, the adsorption and photocatalytic degradation and its kinetics about Methylene blue(MB) were studied systematically. All the TGO-x% showed improved adsorption and photodegradation performance. TGO-25% had excellent adsorptivity while TGO-20% exhibit the highest visible light photocatalytic degradation activity. The adsorption capacity for TGO-25% was 20.25 mg/gcatalyst along with the k1 was about 0.03393 min·gcatalyst/mg, this enhancement was mainly owing to the strong adsorption capacity of GO and the stacking structure of sheets and nanoparticles. GO sheets prevented the agglomeration of TiO2 particles and TiO2 nanoparticles also prevented the agglomeration of GO sheets, which could provides greater surface area. Besides, the remarkably superior photodegradation activity of TiO2/GO composites is mainly attribute to the strong absorption of visible light and the effective charge separation revealed by the photoluminescence, the total removal rate of MB is 97.5% after 35 min adsorption and 140 min degradation, which is 3.5 times higher than that of TiO2.
Childhood motor performance is increased by participation in organized sport: the CHAMPS Study-DK
Authors: Vallence Ann-Maree , Hebert Jeffrey , Jespersen Eva , Klakk Heidi , Rexen Christina , Wedderkopp Niels 
Published: December 2019

AbstractEvidence suggests that motor performance in children is declining globally. We tested whether participation in organized sport is associated with motor performance, and estimate the effect of 30 months participation in organized sport on motor performance. Study participants were 1067 primary school students, enrolled in the Danish Childhood Health, Activity, and Motor Performance School study. Participation in organized sport was reported via text messaging. Coordination-related motor performance composite, fitness-related motor performance composite, and total motor performance composite were calculated. Data were analyzed using Generalized Estimating Equations. Participation in organized sport was positively associated with motor performance (all composites) in models that did and did not control for baseline motor performance. For models that did not control for baseline motor performance, this equated to 2–6% increases in motor performance per weekly sport session; for models that did control for baseline motor performance, this equated to 1–5% increases in motor performance per weekly sport session. Positive associations between participation in organized sport and motor performance identify participation in organized sport as a way to improve motor performance in children. These results might provide the basis to determine whether participation in organized sport could be beneficial for children with developmental movement disorders.
The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
Authors: Choi Byung Gon , Hong Ji Youn , Hong Joo Ran , Hur Min Seok , Kim Sung Min , Lee Yang Won , Choe Yong Beom , Ahn Kyu Joong 
Published: December 2019

AbstractInterleukin 17 (IL-17) plays pivotal role in the pathogenesis of psoriasis. In a previous study, we identified a locus in the IL17F gene that is associated with psoriasis, the IL17F rs763780 (His161Arg) T/C variant. The current study aimed to elucidate the association between this polymorphism and psoriasis, and to determine its effect on serum levels of cytokine. A total of 116 psoriasis patients and 97 healthy volunteers were recruited. Genotyping analysis was performed using quantitative polymerase chain reaction, and serum levels of cytokine were measured using a multiplex immunoassay. The IL17F His161Arg polymorphism was significantly associated with psoriasis based on the genotype and allele analyses. Psoriasis patients harbouring the mutant allele had significantly increased serum levels of IL-17F. Our results suggest that this polymorphism is a potential risk locus for psoriasis and that it results in a direct increase in IL-17F production.
Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials
Authors: Vasile Eugeniu , Pandele Andreea M. , Andronescu Corina , Selaru Aida , Dinescu Sorina , Costache Marieta , Hanganu Anamaria , Raicopol Matei D. , Teodorescu Mircea 
Published: December 2019

AbstractPoly(propylene fumarate) (PPF) is a linear unsaturated polyester which has been widely investigated for tissue engineering due to its good biocompatibility and biodegradability. In order to extend the range of possible applications and enhance its mechanical properties, current approaches consist in the incorporation of various fillers or obtaining blends with other polymers. In the current study we designed a reinforcing agent based on carboxylated graphene oxide (GO-COOH) grafted with 2-hydroxyethyl methacrylate (GO@HEMA) for poly(propylene fumarate)/poly(ethylene glycol) dimethacrylate (PPF/PEGDMA), in order to enhance the nanofiller adhesion and compatibility with the polymer matrix, and in the same time to increase the crosslinking density. The covalent modification of GO-COOH was proved by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and Raman spectroscopy. The mechanical properties, water uptake capacity, morphology, biodegradability, mineralization and in vitro cytotoxicity of PPF/PEGDMA hybrid materials containing GO@HEMA were investigated. A 14-fold increase of the compressive modulus and a 2-fold improvement in compressive strength were observed after introduction of the nanofiller. Moreover, the decrease in sol fraction and solvent swelling in case of the hybrid materials containing GO@HEMA suggests an increase of the crosslinking density. SEM images illustrate an exfoliated structure at lower nanofiller content and a tendency for agglomeration at higher concentrations. Finally, the synthesized hybrid materials proved non-cytotoxic to murine pre-osteoblast cells and induced the formation of hydroxyapatite crystals under mineralization conditions.
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
Authors: Nersisyan Lilit , Nikoghosyan Maria ,   The Genome of the Netherlands consortium, Francioli Laurent C. , Menelaou Androniki , Pulit Sara L. , Elbers Clara C. , Kloosterman Wigard P. , van Setten Jessica , Nijman Isaäc J. , Renkens Ivo , de Bakker Paul I. W. , van Dijk Freerk , Neerincx Pieter B. T. , Deelen Patrick , Kanterakis Alexandros , Dijkstra Martijn , Byelas Heorhiy , van der Velde K. Joeri , Platteel Mathieu , Swertz Morris A. , Wijmenga Cisca , Palamara Pier Francesco , Pe’er Itsik , Ye Kai , Ye Kai , Lameijer Eric-Wubbo , Moed Matthijs H. , Beekman Marian , de Craen Anton J. M. , Suchiman H. Eka D. , Slagboom P. Eline , Guryev Victor , Abdellaoui Abdel , Jan Hottenga Jouke , Kattenberg Mathijs , Willemsen Gonneke , Boomsma Dorret I. , van Leeuwen Elisabeth M. , Karssen Lennart C. , Amin Najaf , Rivadeneira Fernando , Isaacs Aaron , Hofman Albert , Uitterlinden André G. , van Duijn Cornelia M. , van Oven Mannis , Kayser Manfred , Vermaat Martijn , Laros Jeroen F. J. , den Dunnen Johan T. , van Enckevort David , Mei Hailiang , Li Mingkun , Stoneking Mark , van Schaik Barbera D. C. , Bot Jan , Marschall Tobias , Schönhuth Alexander , Hehir-Kwa Jayne Y. , Handsaker Robert E. , Polak Paz , Sohail Mashaal , Vuzman Dana , Estrada Karol , McCarroll Steven A. , Sunyaev Shamil R. , Hormozdiari Fereydoun , Koval Vyacheslav , Medina-Gomez Carolina , Oostra Ben , Veldink Jan H. , van den Berg Leonard H. , Pitts Steven J. , Potluri Shobha , Sundar Purnima , Cox David R. , de Knijff Peter , Li Qibin , Li Yingrui , Du Yuanping , Chen Ruoyan , Cao Hongzhi , Wang Jun , Li Ning , Cao Sujie , Bovenberg Jasper A. , van Ommen Gert-Jan B. , Arakelyan Arsen 
Published: December 2019

AbstractTelomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother’s, and, to a lesser extent, with father’s TL having the strongest influence on the offspring. In this cohort, mother’s, but not father’s age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait.
Deep learning and taphonomy: high accuracy in the classification of cut marks made on fleshed and defleshed bones using convolutional neural networks
Authors: Cifuentes-Alcobendas Gabriel , Domínguez-Rodrigo Manuel 
Published: December 2019

AbstractAccurate identification of bone surface modifications (BSM) is crucial for the taphonomic understanding of archaeological and paleontological sites. Critical interpretations of when humans started eating meat and animal fat or when they started using stone tools, or when they occupied new continents or interacted with predatory guilds impinge on accurate identifications of BSM. Until now, interpretations of Plio-Pleistocene BSM have been contentious because of the high uncertainty in discriminating among taphonomic agents. Recently, the use of machine learning algorithms has yielded high accuracy in the identification of BSM. A branch of machine learning methods based on imaging, computer vision (CV), has opened the door to a more objective and accurate method of BSM identification. The present work has selected two extremely similar types of BSM (cut marks made on fleshed an defleshed bones) to test the immense potential of artificial intelligence methods. This CV approach not only produced the highest accuracy in the classification of these types of BSM until present (95% on complete images of BSM and 88.89% of images of only internal mark features), but it also has enabled a method for determining which inconspicuous microscopic features determine successful BSM discrimination. The potential of this method in other areas of taphonomy and paleobiology is enormous.
Effect of Indian Ocean–Pacific SST Pattern in Autumn on Winter Wheat Climatic Yield in the North China Plain in the Following Year and a Possible Mechanism
Authors: Xie Qingyan , Li Jianping 
Published: December 2019

AbstractEnsuring stable crop yield increases to meet rising demand is an important issue globally, particularly when accounting for climate change. In this study, using observations, reanalysis datasets, and the Hodrick and Prescott filter method, we find that changes in a distinct pattern of Indian Ocean–Pacific five-pole (IPFP) SST (sea surface temperature) are strongly linked to the ensuing year’s winter wheat climatic yield (the part of yield that fluctuation caused by climatic factors change) in the North China Plain (NCP), which is the main production region of winter wheat in China. Here we define a normalized IPFP index (IPFPI) and demonstrate that the autumn IPFPI (1948–2014) is well correlated with the ensuing year’s winter wheat climatic yield (1949–2015), particularly for October (r = 0.69; n = 67; P < 0.001). A composite analysis shows that the October IPFP is correlated with sowing-period and emergence-period climate factors in the NCP. When the October IPFP is in a positive phase, the atmosphere geopotential height fields and water vapor flux are bebefitial to rainfall formation in NCP, and the precipitation and soil moisture are higher in NCP and benefit winter wheat growth, thus increasing the climatic yield. In addition, accumulated rainfall and soil water content might influence winter wheat growth from sowing and emergence (autumn) to the returning green stage (following spring).
Environmental DNA concentrations are correlated with regional biomass of Atlantic cod in oceanic waters
Authors: Salter Ian , Joensen Mourits , Kristiansen Regin , Steingrund Petur , Vestergaard Poul 
Published: December 2019

AbstractEnvironmental DNA (eDNA) has emerged as a powerful approach for studying marine fisheries and has the potential to negate some of the drawbacks of trawl surveys. However, successful applications in oceanic waters have to date been largely focused on qualitative descriptions of species inventories. Here we conducted a quantitative eDNA survey of Atlantic cod (Gadus morhua) in oceanic waters and compared it with results obtained from a standardized demersal trawl survey. Detection of eDNA originating from Atlantic cod was highly concordant (80%) with trawl catches. We observed significantly positive correlations between the regional integrals of Atlantic cod biomass (kg) and eDNA quantities (copies) (R2 = 0.79, P = 0.003) and between sampling effort-normalised Catch Per Unit Effort (kg hr−1) and eDNA concentrations (copies L−1) (R2 = 0.71, P = 0.008). These findings extend the potential application of environmental DNA to regional biomass assessments of commercially important fish stocks in the ocean.
Aggressive dominance can decrease behavioral complexity on subordinates through synchronization of locomotor activities
Authors: Alcala Rocio Soledad , Caliva Jorge Martin , Flesia Ana Georgina , Marin Raul Hector , Kembro Jackelyn Melissa 
Published: December 2019

AbstractSocial environments are known to influence behavior. Moreover, within small social groups, dominant/subordinate relationships frequently emerge. Dominants can display aggressive behaviors towards subordinates and sustain priority access to resources. Herein, Japanese quail (Coturnix japonica) were used, given that they establish hierarchies through frequent aggressive interactions. We apply a combination of different mathematical tools to provide a precise quantification of the effect of social environments and the consequence of dominance at an individual level on the temporal dynamics of behavior. Main results show that subordinates performed locomotion dynamics with stronger long-range positive correlations in comparison to birds that receive few or no aggressions from conspecifics (more random dynamics). Dominant birds and their subordinates also showed a high level of synchronization in the locomotor pattern, likely emerging from the lack of environmental opportunities to engage in independent behavior. Findings suggest that dominance can potentially modulate behavioral dynamics through synchronization of locomotor activities.
Effect of quasiparticle excitations and exchange-correlation in Coulomb drag in graphene
Authors: Fandan Rajveer , Pedrós Jorge , Guinea Francisco , Boscá Alberto , Calle Fernando 
Published: December 2019

AbstractCoulomb drag in double layer graphene systems separated by an h-BN interlayer allows probing of the electron-electron interactions in the effective limit of zero layer separation. Although these interactions can be influenced by plasmons, phonons and exchange and correlation effects, these excitations have never been studied altogether, missing the effects of their coupling on the drag physics. Here we study theoretically the effects of these quasiparticles and their coupling, including also the effects of the electronic exchange and correlation, and demonstrate that the drag resistivity can attain a maximum value at room temperature and beyond, where hybridized plasmon-phonon modes contribute significantly. In particular, the hybridization of the plasmons with the hyperbolic phonons of h-BN, confined within the reststrahlen bands, enhance the drag resistivity. This study paves the way for the exploration of novel many-body physics phenomena in systems coupled through emerging 2D hyperbolic materials.
The Importance of the Working Alliance in the Treatment of Cluttering
Authors: Sønsterud Hilda 
Published: December 2019

It is expected that the quality of the working alliance between speech-language pathologists (SLPs) and persons who clutter matters. The termworking allianceis an important concept in cluttering and stuttering treatment and can be described as the degree to which the therapy dyad is engaged in collaborative, purposive work. The concept includes, among other factors, a shared understanding of therapy goals and the relevance of the therapy approach to achieving those goals. There has been an increasing interest regarding research that supports the therapeutic relationship as an evidence-based component of interventions in speech-language pathology, and recent research (Sønsterud et al., 2019) supports that a critical element for successful stuttering therapy lies, among other factors, in the concept of the working alliance.PurposeAlthough there is consensus that SLPs should openly and honestly discuss the individual's goals and expectations for therapy, personal motivation and the impact of the working alliance for people who clutter have not been investigated. This clinical focus article highlights the importance of open and honest discussion around not only the individual's goals for treatment but also the tasks or activities to be incorporated in that treatment. Relevant and specific quantitative and qualitative assessments for measuring the working alliance are required to investigate the concept of the working alliance in more detail. The Working Alliance Inventory–Short Revised version is regarded to be one useful tool to evaluate this client–clinician relationship. The Working Alliance Inventory–Short Revised version is quick and easy to use and explores the working alliance across the 3 processes of bond, goal, and task.ConclusionThis clinical focus article contains no research results. Anyhow, some considerations on this concept, both from a person who clutters and SLP perspectives, are included in this clinical focus article. Research is required to investigate whether shared understanding of treatment goals, agreement on tasks, and a respectful and trustful bond may become important predictors for successful therapy outcome also for people who clutter.