bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of stigma, hope and social support on quality of life among Chinese patients diagnosed with oral cancer: A cross-sectional study
Authors: Zhang Ying , Cui Chun-Ying , Wang Yu , Wang Lie 
Published: March 2020

Abstract
Background Improving quality of life (QoL) has been one of the goals of health care for people living with oral cancer. This study aimed to assess QoL and investigate the effects of stigma, hope, and social support on QoL among Chinese oral cancer patients.Methods A cross-sectional study was conducted at the Department of Stomatology, Shengjing Hospital of China Medical University and Stomatology Hospital of China Medical University in Liaoning Province, China, between May 2016 and October 2017. A total of 230 oral cancer patients were recruited to complete a questionnaire including the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N), the Social Impact Scale (SIS), the Herth Hope Index (HHI) and the Multidimensional Scale of Perceived Social Support (MSPSS). Univariate one-way ANOVA/t-test, Person’s r and hierarchical linear regression analysis were conducted to explore the factors influencing QoL and the relationships between stigma, hope, perceived social support and QoL.Results The mean QoL score was 90.85±20.15 among the patients with oral cancer. Stigma was negatively related to QoL, explaining 39.3% of the variance. In addition, hope and perceived social support were positively associated with QoL, explaining 8.1% of the variance.Conclusion Overall, Chinese patients with oral cancer suffer from low QoL. Stigma was significantly and negatively associated with QoL, while hope and perceived social support were positively associated with QoL. Oral cancer patients’ psychological states should be addressed, and adequate intervention based on positive psychological resources should be provided to improve the QoL of patients with oral cancer.
The Desire to Die in Palliative Care: A sequential mixed methods study to develop a semi-structured clinical aproach
Authors: Kremeike Kerstin , Frerich Gerrit , Romotzky Vanessa , Bostroem Kathleen , Dojan Thomas , Galushko Maren , Shah-Hosseini Kija , Juenger Saskia , Rodin Gary , Pfaff Holger , Perrar Klaus Maria , Voltz Raymond 
Published: March 2020

Abstract
Background: Although desire to die of varying intensity and permanence is frequent in patients receiving palliative care, uncertainty exists concerning appropriate therapeutic responses to it. To support health professionals in dealing with patients´ potential desire to die, a training program and a semi-structured clinical interview approach was developed. This study aimed for a revision of and consensus building on the clinical approach to support proactively addressing desire to die and routine exploration of death and dying distress. Methods: Within a sequential mixed methods design, we invited 16 palliative patients to participate in semi-structured interviews and 377 (inter-)national experts to attend a two-round Delphi process. Interviews were analyzed using qualitative content analysis and an agreement consensus for the Delphi was determined according to predefined criteria. Results : 11 (69%) patients from different settings participated in face-to-face interviews. As key issues for conversations on desire to die they pointed out the relationship between professionals and patients, the setting and support from external experts, if required. A set of 149 (40%) experts (132/89% from Germany, 17/11% from 9 other countries) evaluated ten domains of the semi-structured clinical approach. There was immediate consensus on nine domains concerning conversation design, suggestions for (self-)reflection, and further recommended action. The one domain in which consensus was not achieved until the second round was “proactively addressing desire to die”. Conclusions : We have provided the first semi-structured clinical approach to identify and address desire to die and to respond therapeutically – based on evidence, patients’ views and consensus among professional experts. Trial registration: The study is registered in the German Clinical Trials Register (DRKS00012988; registration date: 27.9.2017) and in the Health Services Research Database (VfD_DEDIPOM_17_003889; registration date: 14.9.2017).
Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study
Authors: Wang Xinru , Shi Jie , Lu Bin , Zhang Weiwei , Yang Yehong , Wen Jie , Hu Renming , Yang Zhen , Wang Xuanchun 
Published: March 2020

Abstract
Background Heat shock protein 27 (HSP27) has been proposed as a vital protective factor in atherosclerosis. The objective of the present study was to evaluate the association between circulating HSP27 and intima–media thickness (IMT) of the common carotid artery in individuals with type 2 diabetes and to determine whether HSP27 represents an independent marker for subclinical atherosclerosis in this patient population. Methods We performed a cross-sectional community-based study consisting in 186 Chinese subjects with a median duration of diabetes of 8.2 years who underwent carotid ultrasound IMT measurement. Serum HSP27 levels were assessed by ELISA. Results Serum HSP27 levels were significantly higher in the IMT (+, >1.0 mm) group than in the IMT (-, ≤1.0 mm) group, with the median value of 8.80 ng/mL (5.62–12.25) and 6.93 ng/mL (4.23–9.60), respectively ( P =0.006). The discriminative value of HSP27 to evaluate IMT was 7.16 ng/mL and the area under the curve was 0.72 (95%CI=0.64–0.80, P=0.0065). Spearman's rank correlation analysis demonstrated that the concentrations of circulating HSP27 were positively correlated with carotid IMT ( r =0.198, P =0.007) and blood urea nitrogen ( r =0.170, P <0.05). Furthermore, in the logistic model, serum HSP27 levels were found to be independent predictors of carotid IMT in type 2 diabetic patients after adjustment for onset age of diabetes, blood pressure, total cholesterol and C-reactive protein. (OR=1.085, P =0.022). Conclusions Circulating HSP27 level positively correlates with carotid IMT, is an independent predictor for early atherosclerotic changes in diabetes, and may represent a novel marker of subclinical atherosclerosis in type 2 diabetes.
Majocchi’s Granuloma on the Forearm Caused by Trichophyton tonsurans in an Immunocompetent Patient
Authors: Zheng Yun-yan , Li Yue , Chen Ming-yan , Mei Qian-yun , Zhang Ru-zhi 
Published: March 2020

Abstract
Majocchi's granuloma is an uncommon fungal infection of the dermis and subcutaneous tissue. The most frequently identified cause of Majocchi’s granuloma is anthropophilic Trichophyton rubrum, and it is most commonly located on the anterior aspect of the lower limbs in women. Here, we report a case of Majocchi’s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed a dense dermal infiltrate composed of lymphoplasmacytic cells and neutrophils, with hyphae in the dermis. The presence of the fungus, Trichophyton tonsurans, was confirmed by mycological examination. Therefore, histological and mycological examination conformed the diagnosis of Majocchi’s granuloma. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which facilitated a complete resolution of the lesions
Expression of tripartite motif‑containing 44 and its prognostic and clinicopathological value in human malignancies：a meta-analysis
Authors: Xiao Guoliang , Yang Qiuxi , Bao Ziwei , Mao Haixia , Zhang Yi , Lin Shibu 
Published: March 2020

Abstract
Background: Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRIM44 in human malignancies and to describe its possible mechanisms of oncogenesis. Methods: The available databases worldwide were searched for eligible studies that evaluated the clinicopathological and prognostic roles of TRIM44 in patients with malignancies.The hazard ratio (HR) and combined odds ratios (ORs) were combined to assess the predictive role of TRIM44 using Stata/SE 14.1 software. Results: A total of 1,740 patients from thirteen original studies were finally included in this study . The results of the combined analysis showed that over-expression of TRIM44 was significantly correlated with shorter overall survival (OS) in cancer patients (HR = 2.16, 95% CI: 1.65–2.83) as well as worse disease-free survival (DFS) (HR= 2.13 (95% CI 1.45–3.11). Additionally, the combined ORs indicated that elevated TRIM44 expression was significantly associated with lymph node metastasis (OR=2.69, 95% CI: 1.71–4.24), distant metastasis (OR=10.35, 95% CI: 1.01-106.24), poor tumor differentiation (OR=1.78, 95% CI: 1.03–3.09), increased depth of tumor invasion (OR=2.72, 95% CI: 1.73–4.30), advanced clinical stage (OR=2.75, 95% CI: 2.04-3.71), and recurrence (OR=2.30, 95% CI: 1.34–3.95). Analysis of expression using Gene Expression Profiling Interactive Analysis (GEPIA) indicated that the expression of TRIM44 was higher in most tumor tissues than in the corresponding normal tissues.Survival analysis indicated high levels of TRIM44 mRNA were associated with unfavorable OS and DFS in various malignancies. Conclusions: TRIM44 may serve as a valuable prognostic biomarker and a potential therapeutic target for patients with malignancies.
Oral intermittent Vitamin D substitution: Influence of pharmaceutical form and dosage frequency on medication adherence: A randomized clinical trial
Authors: Rothen Jean-Pierre , Rutishauser Jonas , Walter Philipp N , Hersberger Kurt E , Arnet Isabelle 
Published: March 2020

Abstract
Background

To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.

Methods

A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 x 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value <50 nmol/l and age ≥18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels.

Results

The focus group reached consensus for preference of a monthly administration of solid forms to adults.

Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5 – 100.0%) than weekly (66.4 – 98.1%) administration. Vitamin D levels increased significantly (p<0.001) in all participants. An optimal value of >75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants.

Conclusions

Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of >75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.
Effect of the Selection Pressure of Vaccine Antibodies on Evolution of H9N2 Avian Influenza Virus in Chickens
Authors: SU Hailong , Zhao Yu , Zheng Lirong , Wang Shifeng , Shi Huoying , Liu Xiufan 
Published: March 2020

Abstract
H9N2 avian influenza virus has spread worldwide, and vaccination with an inactivated virus is currently the major prevention method in China. To further understand the effect of the selection pressure from antibodies on the evolution of H9N2 avian influenza virus, F/98 (A/Chicken/Shanghai/F/98), which is the vaccine representative of H9N2 avian influenza virus in East China, was used for serial passaging for 20 generations in chickens with and without vaccination. After plaque purification from trachea and lung tissues, 390 quasispecies were obtained. The second-generation quasispecies under the selection pressure of vaccine antibodies had undergone 100% antigen variation, while after passaging to the fifth generation, only 30-40% of the quasispecies displayed antigen variation when there was no selection pressure of vaccine antibodies, implying that the selection pressure of vaccine antibodies promotes the antigen variation of F/98. We found for the first time that there were three mutation hotspots in the HA genes of the quasispecies under the selection pressure of vaccine antibodies, which were K131R, A168T, and N201D. Moreover, under the selection pressure of vaccine antibodies, 10 amino acids (67-76) of the NA protein of all quasispecies were deleted, and PB2 of the quasispecies had undergone a high-frequency R355K mutation. However, without selection pressure of vaccine antibodies, NP had undergone two high-frequency mutations, namely, V186I and L466I, and a high-frequency mutation of L77I appeared in the NS gene. This result shows that the vaccine antibody selection pressure could control and regulate gene variation of the F/98 virus. Compared to that of the parental virus F/98, the EID 50 of the twentieth passaged virus under the selection pressure of vaccine antibodies did not change, while the EID 50 of the twentieth passaged virus without selection pressure of vaccine antibodies was significantly enhanced by 794 times. Furthermore, the twentieth passaged virus with selection pressure from vaccine antibodies lost its lethal ability in embryonated chicken eggs, whereas the EID 50 of the twentieth passaged virus without selection pressure of vaccine antibodies increased to 6.3 times that of the F/98 strain. All the above results show that the selection pressure of vaccine antibodies promotes the antigen variation of H9N2 avian influenza virus and plays a role in regulating and controlling gene mutation of H9N2 avian influenza virus.
Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019: a retrospective cross-sectional study
Authors: Sun Jia-Kui , Zhang Wen-Hao , Zou Lei , Liu Ying , Li Jing-Jing , Kan Xiao-Hua , Dai Lian , Shi Qian-Kun , Yuan Shou-Tao , Yu Wen-Kui , Xu Hong-Yang , Gu Wei , Qi Jian-Wei 
Published: March 2020

Abstract
Background: To investigate the correlations between serum calcium and clinical severity and outcomes in patients with coronavirus disease 2019 (COVID-19).Methods: In this clinical retrospective study, the levels of serum calcium, hormone levels and clinical laboratory parameters of admission were recorded. The clinical severity and outcome variables were also recorded.Results: From February 10 to February 28 2020, 241 patients were enrolled in this study. Of these patients, 180 (74.7%) had hypocalcemia on admission. The median serum calcium levels were 2.12 (IQR, 2.04-2.20) mmol/L, median parathyroid hormone (PTH) levels were 55.27 (IQR, 42.73-73.15) pg/mL, median 25-hydroxy-vitamin D (VD) levels were 10.20 (IQR, 8.20-12.65) ng/mL. The serum calcium levels were significantly positive correlated with VD levels (P =0.004), whereas negative correlated with PTH levels (P = 0.048). Patients with lower serum calcium levels (especially ≤2.0 mmol/L) had worse clinical parameters, higher incidence of organ injury septic shock and higher 28-day mortality. The areas under the receiver operating characteristic curves of multiple organ dysfunction syndrome, septic shock, and 28-day mortality were 0.923 (P <0.001), 0.905 (P =0.001), and 0.929 (P <0.001), respectively. The overall mortality of COVID-19 was 4.1% (10/241), whereas the mortality of critical patients was up to 40.0% (10/25). Conclusions: Serum calcium was associated with clinical severity and prognosis of patients with COVID-19. Hypocalcemia may be associated with imbalanced VD and PTH.
Impact of invasive species on the density and body size of an insular endemic lizard (Trachylepis atlantica)
Authors: Gasparotto Vinícius Peron de Oliveira , Micheletti Tatiane , Mangini Paulo Rogério , Dias Ricardo Augusto 
Published: March 2020

Abstract
Background Invasive species have been responsible for the extinction of several species around the world. The Noronha skink is an endemic lizard from the Fernando de Noronha archipelago, Brazil, that has been suffering from habitat changes and the introduction of invasive species. Results The density of Trachylepis atlantica on the main island was 0.167 ± 0.090 individuals/m2; that on the secondary islands was 0.357 ± 0.170 individuals/m2; and that on the entire archipelago was 0.184 ± 0.109 individuals/m2. Moreover, the morphometric parameters of the Noronha skink were compared between the main island and secondary islands. The values of all parameters were higher on the secondary islands. Conclusion The occurrence of invasive species on the main island seems to be a determining factor in the density and body size of the Noronha skink.
Awareness towards signs and symptoms of stroke and assessment of factors associated with knowledge of five symptoms of stroke among general public Malaysia: A regression analysis.
Authors: Albohari Abdullah Abdulmajid Abdo Ahmed , AL-Shami Abdulkareem Mohammed , Nahas Abdul Rahman Fata , Aslam Adeel , Zawiah Mohammed , Jamshed Shazia 
Published: March 2020

Abstract
Background Stroke remains one of the leading cause of mortality and disability in developing and developed countries. Lack of awareness towards signs and symptoms of stroke leads to delayed presentation to the hospital contributing towards increased morbidity and mortality. This study aimed to assess the awareness of and action towards signs and symptoms of stroke. Methodology This is cross-sectional study executed among 393 lay public who aged 18-64 years old in Kuantan, Pahang, Malaysia using structured questionnaire survey. Results Mojority of respondents (78) identifed sudden face, arms and leg numbness whereas 42% of them identifed problems in vision. However, 10.4% were unaaware of any symptoms while 30% identified appropriate action. Furthermore, 88.8% recognized at least one stroke symptoms and 27.5% of them identifed all five stroke symptoms as well as 9.4% of individuals had excellent awareness (aware of all five stroke symptoms and appropriate action “calling an ambulance”). Multivariable logistic regression shows that individuals aged 18-45 years (OR=0.054, 95% Cl=0.006-0.500, p =0.010), self-employed (OR=12.430, 95% Cl=1.372-31.908, p =0.028), those who were diagnosed with hypertension (OR=0.129, 95% Cl=0.025-0.673, p =0.015) and student (OR=35.945. 95% Cl=1.745-740.615, p =0.020) were more likely to recognise all the five stroke symptoms and appropriate action. Conclusion The awareness and action towards signs, symptoms is poor among lay public in Kuantan, Malaysia. Therefore, the findings of this study would be a baseline for program interventions that focus on public awareness and policy development on stroke management.
Prevalence Of Suicidal Ideation And Associated Risk Factors Among College Students: Eritrea
Authors: Berhe Michael , Tewelde yonas , yohanes Filimon , Berhane Haben 
Published: March 2020

Abstract
Suicidal ideation is a common medical term and refers to the thoughts one has about taking his or her own life, with some degree of intent. Although a person may experience suicidal thoughts, it does not mean he or she is in imminent danger of committing suicide.it is influenced by many risk factors like gender, age, depression, family support and others. Suicidal ideation and suicidal attempt are significant among college students. Suicide ideation is considered to be an important precursor to later attempted and completed suicide [52] and is of major public health significance. So the purpose of the study is to assess the prevalence of suicidal ideation and its risk factors among 7 Eritrean colleges. This study was conducted on 466 college students and employed a cross sectional study design with stratification sampling. Students self-completed a questionnaire which included a brief demographic section and a section with MID, HADS, AUDIT, MSSPS and MSSI. THE data was analyzed using SPSS version 20. The overall occurrence of suicidal ideations in the study sample was 25.9%. The risk factors identified in the study were depression, anxiety, alcohol abuse and perceived social support, attending religious activity and satisfaction with the credit hours assigned were significantly associated with suicidal ideation and they were found to be as protective factors. While no significant differences among those with suicidal ideations in terms of gender, religion, study program, where you live. The results of this study highlight the importance of establishing prevention and intervention programmers on university campuses to create more awareness about suicide and offer more education to students on this topic in general, as well as to specifically offer counseling and support to students suffering from suicidal ideations.
Construction of SSR linkage maps and identification of QTL for resistance to root rot in sweetpotato (Ipomoea batatas (L.) Lam.)
Authors: Ma Zhimin , Gao Wenchuan , Liu Lanfu , Liu Minghui , Zhao Ning , Han Meikun , Wang Zhao , Jiao Weijing , Gao Zhiyuan , Hu Yaya , Liu Qingchang 
Published: March 2020

Abstract
Background: Sweetpotato root rot is a devastating disease caused by Fusarium solani that causes significant yield losses of sweetpotato in China. There is currently no effective method to control the disease. The breeding of resistant varieties is the most effective and economic way to control the disease. To date, quantitative trait locus (QTL) for resistance to root rot have not been reported and the biological mechanisms of resistance remain unclear in sweetpotato. Thus, it is necessary and worthwhile to identify resistance loci to help develop disease-resistant varieties. Results: In this study, we constructed genetic linkage maps of sweetpotato using a mapping population consisting of 300 individuals derived from a cross between Jizishu 1 and Longshu 9 by simple sequence repeat (SSR) markers, and mapped seven QTLs for resistance to root rot. In total, 484 and 573 polymorphic SSR markers were grouped into 90 linkage groups for Jizishu 1 and Longshu 9, respectively. The total map distance for Jizishu 1 was 3,974.24 cM, with an average marker distance of 8.23 cM. The total map distance for Longshu 9 was 5,163.35 cM, with an average marker distance of 9.01 cM. Five QTLs ( qRRM_1 , qRRM_2 , qRRM_3, qRRM_4 , and qRRM_5 ) were located in five linkage groups of Jizishu 1 map explaining 52.6-57.0% of the variation. Two QTLs ( qRRF_1 and qRRF_2 ) were mapped on two linkage groups of Longshu 9 explaining 57.6% and 53.6% of the variation. 71.4 % of the QTLs had a positive effect on the variation. Three of the seven QTLs, qRRM_3 , qRRF_1 , and qRRF_2 , were colocalized with markers IES43-5mt, IES68-6fs**, and IES108-1fs, respectively. Conclusions: To our knowledge, this is the first report on the construction of a genetic linkage map for purple sweetpotato (Jizishu 1) and the identification of QTLs associated with resistance to root rot in sweetpotato using SSR markers. These QTLs will have practical significance for the fine mapping of root rot resistance genes and play an important role in sweetpotato marker-assisted breeding.