bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment Outcome and Its Determinants among Patients Admitted to Stroke Unit of Jimma University Medical Center, Southwest Ethiopia
Authors: Zewudie Ameha Zeleke , Regasa Tolcha , Hambisa Solomon , Nureye Dejen , Mamo Yitagesu , Aferu Temesgen , Feyissa Desalegn , Yosef Tewodros 
Published: December 2020

Background. Stroke is a public health problem in Ethiopia. Despite the high prevalence of stroke in Ethiopia, there is a paucity of data with regard to drug treatment, treatment outcome, and risk factors of poor treatment outcome of stroke. Hence, this study is aimed at assessing treatment outcome and its determinants among patients admitted to stroke unit of Jimma University Medical Center (JUMC). Methods. A two-year hospital-based retrospective cross-sectional study was employed to analyze the medical records of patients admitted with stroke to stroke unit of Jimma University Medical Centre from February 1st, 2016 to March 30th, 2018. Data was entered by Epidata manager version 4.0.2 and analyzed by SPSS version 24. Multivariable logistic regression analysis with the backward stepwise approach was done to identify independent predictors of poor treatment outcome of stroke. Variables with

P

value less than 0.05 were considered as statically significant determinants of poor treatment outcome. Results. Of 220 patients with stroke admitted to the Jimma University, 67.30% were male. Nearly two thirds (63.18%) of them had poor treatment outcomes. Dyslipidimics were administered to 60% of the patients, and the most popular antiplatelet used was aspirin, which was prescribed to 67.3% the patients.

Age
≥
65

adjusted

odd

ratio

((AOR): 2.56; 95% CI: 1.95-9.86,

P
=
0.001

), presence of comorbidity (AOR: 5.25; 95% CI: 1.08-17.69,

P
<
0.001

), admission with hemorrhagic stroke (AOR: 18.99; 95% CI: 7.05-42.07,

P
<
0.001

), and admission to the hospital after 24 hour of stroke onset (AOR: 4.98; 95% CI: 1.09-21.91,

P
=
0.03

) were independent predictors of poor treatment outcomes. Conclusion. Substantial numbers of stroke patients had poor treatment outcomes. Elderly patients, patients diagnosed with hemorrhagic stroke, patients with comorbidity, and those with delayed hospital admission were more likely to have poor treatment outcome. Hence, frequent monitoring and care should be given for the aforementioned patients. Awareness creation on the importance of early admission should be delivered particularly for patients who have risk factors of stroke (cardiovascular diseases).
Adília & Ana C.: performances autorais
Authors: Sales Paulo Alberto da Silva 
Published: December 2020

Desenvolve-se um estudo comparativo entre a criação poética de Adília Lopes e de Ana Cristina Cesar no que diz respeito à ficcionalização de referências autobiográficas para a constituição de um sujeito lírico no/pelo texto. Por meio da leitura de poemas pertencentes aos livros Bandolim, de Adília, publicado em 2016, e Poética (2013), que reúne toda a obra de Ana C., evidencia-se como ambas as poetas se servem da narrativização do verso para criar uma prosa conversacional endereçada à primeira, à segunda e à terceira pessoas do discurso. Por fim, reinvestindo na relação entre linguagem e experiência, conclui-se que tanto Adília quanto Ana C. criam poéticas híbridas, intertextuais e que deslegitimam os gêneros literários.
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Authors: Li Jieliang , Huynh Luong , Cornwell William D. , Tang Moon-Shong , Simborio Hannah , Huang Jing , Kosmider Beata , Rogers Thomas J. , Zhao Huaqing , Steinberg Michael B. , Thu Thi Le Le , Zhang Lanjing , Pham Kien , Liu Chen , Wang He 
Published: December 2020

Objective:
Electronic cigarette (e-cig) use has recently been implicated in promoting atherosclerosis. In this study, we aimed to investigate the mechanism of e-cig exposure accelerated atherosclerotic lesion development.

Approach and Results:

Eight-week-old ApoE
−/−
mice fed normal laboratory diet were exposed to e-cig vapor (ECV) for 2 hours/day, 5 days/week for 16 weeks. We found that ECV exposure significantly induced atherosclerotic lesions as examined by Oil Red O staining and greatly upregulated TLR9 (toll-like receptor 9) expression in classical monocytes and in the atherosclerotic plaques, which the latter was corroborated by enhanced TLR9 expression in human femoral artery atherosclerotic plaques from e-cig smokers. Intriguingly, we found a significant increase of oxidative mitochondria DNA lesion in the plasma of ECV-exposed mice. Administration of TLR9 antagonist before ECV exposure not only alleviated atherosclerosis and the upregulation of TLR9 in plaques but also attenuated the increase of plasma levels of inflammatory cytokines, reduced the plaque accumulation of lipid and macrophages, and decreased the frequency of blood CCR2
+
(C-C chemokine receptor type 2) classical monocytes. Surprisingly, we found that cytoplasmic mitochondrial DNA isolated from ECV extract-treated macrophages can enhance TLR9 activation in reporter cells and the induction of inflammatory cytokine could be suppressed by TLR9 inhibitor in macrophages.

Conclusions:
E-cig increases level of damaged mitochondrial DNA in circulating blood and induces the expression of TLR9, which elevate the expression of proinflammatory cytokines in monocyte/macrophage and consequently lead to atherosclerosis. Our results raise the possibility that intervention of TLR9 activation is a potential pharmacological target of ECV-related inflammation and cardiovascular diseases.
Long‐Term PM
2.5
Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta‐Analysis
Authors: Alexeeff Stacey E. , Liao Noelle S. , Liu Xi , Van Den Eeden Stephen K. , Sidney Stephen 
Published: December 2020

Background

Fine particulate matter <2.5 µm in diameter (PM
2.5
) has known effects on cardiovascular morbidity and mortality. However, no study has quantified and compared the risks of incident myocardial infarction, incident stroke, ischemic heart disease (IHD) mortality, and cerebrovascular mortality in relation to long‐term PM
2.5
exposure.

Methods and Results

We sought to quantitatively summarize studies of long‐term PM
2.5
exposure and risk of IHD and stroke events by conducting a review and meta‐analysis of studies published by December 31, 2019. The main outcomes were myocardial infarction, stroke, IHD mortality, and cerebrovascular mortality. Random effects meta‐analyses were used to estimate the combined risk of each outcome among studies. We reviewed 69 studies and included 42 studies in the meta‐analyses. In meta‐analyses, we found that a 10‐µg/m
3
increase in long‐term PM
2.5
exposure was associated with an increased risk of 23% for IHD mortality (95% CI, 15%–31%), 24% for cerebrovascular mortality (95% CI, 13%–36%), 13% for incident stroke (95% CI, 11%–15%), and 8% for incident myocardial infarction (95% CI, −1% to 18%). There were an insufficient number of studies of recurrent stroke and recurrent myocardial infarction to conduct meta‐analyses.

Conclusions

Long‐term PM
2.5
exposure is associated with increased risks of IHD mortality, cerebrovascular mortality, and incident stroke. The relationship with incident myocardial infarction is suggestive of increased risk but not conclusive. More research is needed to understand the relationship with recurrent events.
Praskie Dzieciątko Jezus jako przykład kontrreformacyjnej teatralizacji wiary
Authors: Woszczerowicz Zuzanna 
Published: December 2020

The Infant Jesus of Prague: An Example of Counter-Reformative Theatralisation of FaithThis article concerns issues of the Counter-Reformative theatralisation of church rituals connected with the statue of the Infant Jesus of Prague. The study considers three types of rituals: the tradition of dressing the sculpture in embroidered vestments of different colours, coronation processions, and pilgrimages. It also presents a brief history of the statue and its worship in the Baroque period. Praskie Dzieciątko Jezus jako przykład kontrreformacyjnej teatralizacji wiaryW artykule podjęłam problematykę kontrreformacyjnej teatralizacji rytuałów kościelnych związanych z figurką Praskiego Dzieciątka Jezus. Wyszczególniłam trzy rodzaje obrzędów: tradycję przebierania rzeźby w wielobarwne stroje, procesje z koronacjami figurki oraz pielgrzymki. W celu przybliżenia jej fenomenu przedstawiłam także krótką historię figurki oraz kultu Dzieciątka Jezus w okresie baroku.
Słowniki w dobie digitalizacji na przykładzie Słownika wyrazów bliskoznacznych współczesnego języka słoweńskiego (Slovar sopomenk sodobne slovenščine)
Authors: Gapsa Magdalena 
Published: December 2020

Dictionaries in the Age of Digitisation: An Example of the Thesaurus of Modern Slovene (Slovar sopomenk sodobne slovenščine)The digital revolution enables publishing dictionaries in a digital version, which significantly facilitates access to them by their users, who are no longer mere recipients of the content: their potential is viewed as useful in (co-)editing dictionaries. These changes also enable the introduction of new solutions to improve editorial work. One case in point is the Thesaurus of Modern Slovene (Slovar sopomenk sodobne slovenščine) – the first responsive dictionary, generated mostly automatically based on available language data, which responds both to language changes as well as to the habits and needs of its users. Their opinions and proposals have become integral part of its concept through crowdsourcing. Słowniki w dobie digitalizacji na przykładzie Słownika wyrazów bliskoznacznych współczesnego języka słoweńskiego (Slovar sopomenk sodobne slovenščine)Rewolucja cyfrowa umożliwia udostępnianie słowników w wersji cyfrowej, co znacząco ułatwia dostęp do nich użytkownikom, którzy nie są już tylko odbiorcami treści, ale dostrzega się także ich potencjał przy (współ)redagowaniu słowników. Dzięki niej możliwe jest także wprowadzanie nowych rozwiązań usprawniających prace redakcyjne. Jednym z przykładów jest słoweński Słownik wyrazów bliskoznacznych współczesnego języka słoweńskiego (Slovar sopomenk sodobne slovenščine) – pierwszy słownik reagujący, wygenerowany w większości automatycznie na podstawie dostępnych danych językowych, który reaguje zarówno na zachodzące w języku zmiany, jak i zwyczaje i potrzeby jego użytkowników, których opinie i propozycje stały się jego integralną częścią dzięki zastosowaniu crowdsourcingu.
Hormone Receptor Expression on Endocrine Therapy in Patients with Breast Cancer: A Meta-Analysis
Authors: Zhong Yangyan , Ding Boni , Qian Liyuan , Wu Wei , Wen Yanguang 
Published: December 2020

Objective To evaluate the role of hormone receptor expression on endocrine therapy in patients with breast cancer. Methods The databases were used to collect the effect of high expression and low expression of hormone receptors on the efficacy of endocrine therapy in breast cancer. Two evaluators independently screened the literature based on preset inclusion and exclusion criteria. The quality of the article was evaluated using a modified Newcastle-Ottawa Scale (NOS) system. The survival data included in the literature were extracted and the ln(hazard ratio (HR)) and se[ln(HR)] of the overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) rates were calculated according to different level of hormone receptors. The RevMan 5.3 software was used to evaluate the meta-analysis. Results A total of 13 relevant literature were included in the study. There were 8318 estrogen receptor (ER)-positive and 7926 progesterone receptor (PR)-positive patients. Overall survival, DFS, and RFS rates in high expression of ER(+) patients were significantly higher in low expression of ER(+) patients (OS HR = .59, 95% confidence interval (CI): .46-.76, P < .0001; DFS HR = .62, 95%CI: .50-.76, P < .00001; RFS HR = .44, 95% CI: .33-.58, P < .00001). In patients with high expression of PR(+), OS, DFS, and RFS rates were significantly higher than those with low expression of PR(+) (OS HR = .66, 95% CI: .57-.78, P < .00001; DFS HR = .52, 95% CI: .42-.65, P < .00001; RFS HR = .24, 95% CI: .11-.53, P = .0004). Conclusion The expression of ER and PR are powerful predictors of adjuvant endocrine therapy response. Breast cancer patients with high expression of hormone receptors benefit more from endocrine therapy and have better prognosis.
Microstructural and Mechanical Properties of the Anterolateral Ligament of the Knee
Authors: Patel Ronak M. , Castile Ryan M. , Jenkins Matthew J. , Lake Spencer P. , Brophy Robert H. 
Published: December 2020

Background: The variable anatomy and controversy of the anterolateral ligament (ALL) reflect the complex relationship among the anterolateral knee structures. Purpose/Hypothesis: The purpose was to quantify the microstructural and mechanical properties of the ALL as compared with the anterolateral capsule (ALC) and lateral collateral ligament (LCL). The primary hypotheses were that (1) there is no difference in these properties between the ALL and ALC and (2) the LCL has significantly different properties from the ALL and ALC. Study Design: Descriptive laboratory study. Methods: The LCL, ALL, and ALC were harvested from 25 cadaveric knees. Mechanical testing and microstructural analyses were performed using quantitative polarized light imaging. The average degree of linear polarization (AVG DoLP; mean strength of collagen alignment) and standard deviation of the angle of polarization (STD AoP; degree of variation in collagen angle orientation) were calculated. Results: Linear region moduli were not different between the ALC and ALL (3.75 vs 3.66 MPa, respectively; P > .99). AVG DoLP values were not different between the ALC and ALL in the linear region (0.10 vs 0.10; P > .99). Similarly, STD AoP values were not different between the ALC and ALL (24.2 vs 21.7; P > .99). The LCL had larger modulus, larger AVG DoLP, and smaller STD AoP values than the ALL and ALC. Of 25 knee specimens, 3 were observed to have a distinct ALL, which exhibited larger modulus, larger AVG DoLP, and smaller STD AoP values as compared with nondistinct ALL samples. Conclusion: There were no differences in the mechanical and microstructural properties between the ALL and ALC. The ALC and ALL exhibited comparably weak and disperse collagen alignment. However, when a distinct ALL was present, the properties were suggestive of a ligamentous structure. Clinical Relevance: The properties of the ALL are similar to those of a ligament only when a distinct ALL is present, but otherwise, for the majority of specimens, ALL properties are closer to those of the capsule. Variability in the ligamentous structure of the ALL suggests that it may be more important in some patients than others and reconstruction may be considered in selective patients. Further study is needed to better understand its selective role and optimal indications for reconstruction.
Technique failure in remote patient monitoring program in patients undergoing automated peritoneal dialysis: A retrospective cohort study
Authors: Corzo Leyder , Wilkie Martin , Vesga Jasmin I , Lindholm Bengt , Buitrago Giancarlo , Rivera Angela S , Sanabria Rafael M 
Published: December 2020

Background: Remote patient monitoring (RPM) programs in automated peritoneal dialysis (APD) allow clinical teams to be aware of many aspects and events of the therapy that occur in the home. The present study evaluated the association between RPM use and APD technique failure. Methods: A retrospective, multicentre, observational cohort study of 558 prevalent adult APD patients included between 1 October 2016 and 30 June 2017 with follow-up until 30 June 2018 at Renal Therapy Services network in Colombia. Patients were divided into two cohorts based on the RPM use: APD-RPM ( n = 148) and APD-without RPM ( n = 410). Sociodemographic and clinical characteristics of all patients were summarized descriptively. A propensity score was used to create a pseudo-population in which the baseline covariates were well balanced. The association of RPM with technique failure was estimated adjusting for the competing events death and kidney transplant. Results: Five hundred fifty-eight patients were analyzed. 26.5% had APD-RPM. In the matched sample comprising 148 APD-RPM and 148 APD-without RPM patients, we observed a lower technique failure rate of 0.08 [0.05–0.15] episodes per patient-year in APD-RPM versus 0.18 [0.12–0.26] in APD-without RPM cohort; incidence rate ratio = 0.45 95% confidence interval: [0.22–0.91], p-value = 0.03. Conclusions: The use of an RPM program in APD patients may be associated with a lower technique failure rate. More extensive and interventional studies are needed to confirm its potential benefits and to measure other patient-centered outcomes.
Association between the anticancer efficacy of cabazitaxel and toll-like receptor 4 mediating signaling pathways in metastatic castration-resistant prostate cancer cells
Authors: Guney Eskiler Gamze , Ozkan Asuman Deveci , Eryilmaz Isil Ezgi , Egeli Unal , Cecener Gulsah 
Published: December 2020

Background: We evaluated the effect of cabazitaxel (CAB) as a third-line taxane on Toll-like receptor 4 (TLR4)-mediated signaling pathways, especially NF-κB activity, in metastatic castration-resistant prostate cancer (mCRPC) cells. Methods: CAB cytotoxicity was determined by WST-1 assay. To assess the relationship between CAB efficacy and TLR4 signaling pathways, RT-PCR, western blot and immunofluorescence analysis were performed. Additionally, CAB-mediated apoptotic cell death was assessed by Annexin V and RT-PCR analysis. Results: Our results demonstrated that CAB exerted considerably cytotoxic and apoptotic effects on PC-3 mCRPC cells (p < 0.05). CAB treatment altered TLR4 expression level in a dose-dependent manner. Furthermore, 1 nM CAB treatment significantly induced NF-κB activity through p65 nuclear localization and increased the expression level of caspase-3, Bax and p53. Interestingly, total apoptotic cell death and IRF3 protein levels were increased at 5 nM concentration of CAB despite a decrease in the levels of both NF-κB and pro-apoptotic genes. Conclusions: Therefore, NF-κB activity may be a potential target for the efficacy of CAB in mCRPC cells.
Preferences of people with mental illness for engaging in exercise programs under COVID-19 restrictions
Authors: Chapman Justin J , Hielscher Emily , Patterson Sue , Reavley Nicola , Brown Wendy J , Wyder Marianne , Childs Sarah , Russell Anneliese , Suetani Shuichi , Scott James G 
Published: December 2020

Objectives: People with mental illness may be vulnerable to decline in mental health and reduced physical activity because of the COVID-19 pandemic and associated restrictions. The aim of this study was to inform the design of physical activity interventions for implementation under these conditions to improve/maintain well-being and physical activity in this population. Methods: People with mental illness who had participated in a physical activity program prior to the pandemic were invited to complete a survey about the impact of COVID-19 on mental health and physical activity and their preferences for engaging in a physical activity program under pandemic-related restrictions. Results: More than half the 59 respondents reported worse mental health and lower physical activity during the pandemic. The preferred format for a physical activity program was one-on-one exercise instruction in-person in a park. Program components endorsed as helpful included incentivization, provision of exercise equipment and fitness devices, and daily exercise programs. About a third of the participants reported limitations in using technology for a physical activity program. Conclusions: In-person exercise support is preferred by people with mental illnesses during pandemic-related restrictions. Enablement strategies such as providing equipment and self-monitoring devices should be utilized; assistance may be needed to incorporate the use of technology in exercise programs.
Effectiveness of a Care Delivery Model for High-Need Older Adults in Communities
Authors: Chen Kuei-Min , Hsu Hui-Fen , Yang Li-Yen , Chang Chiang-Ching , Chen Yu-Ming , Chang Wei-Yun 
Published: December 2020

Purpose: This study aimed to test the effectiveness of High-Need Community-Dwelling Older Adults Care Delivery Model (HCOACDM) in Taiwan. Methods: A cluster randomized controlled trial with repeated measures design was conducted in eight community care centers, involving 145 high-need older adults who were assigned to the intervention group or comparison group. The HCOACDM was provided over 6 months. Functional ability, quality of life, depressive symptoms, and health care and social service utilizations were measured at baseline, at 3 months, and 6 months into the intervention. The participants’ satisfaction was measured at the end of 6-month intervention. Results: Positive effects were shown on all variables in the intervention group at both the 3-month and 6-month intervals (all p < .05). The intervention group had a higher satisfaction with care delivery than the comparison group ( p < .05). Discussion: The promising findings supported a long-term implementation of the HCOACDM as applicable and beneficial.
Retrospective Evaluation of Number of Surgeries and Parent Ratings of Academic and Behavioral Functioning Among Children With Isolated Oral Clefts
Authors: Conrad Amy L. , Albert Meredith , Crerand Canice E. , Crilly Bellucci Claudia , Heppner Celia E. , Sheikh Farah , Woodard Suzanne , Kapp-Simon Kathleen A 
Published: December 2020

Objective: The purpose of this study was to evaluate possible relationships between number of surgeries and parent ratings of academic functioning among children with isolated oral clefts. Design: Multicenter, retrospective cohort study including structured interviews, questionnaires, and chart reviews. Setting: Completion of questionnaires occurred during clinical visits at 6 different cleft centers across North America. Participants: Parents of 285 children with isolated clefts of the lip and/or palate, aged 8 to 10 years old, participated in structured interviews and completed questionnaires regarding the academic and behavioral functioning of their children. Main Outcome Measures: Parent interview and medical chart review of number of surgeries to date and parent ratings on the Adaptive Behavior Assessment System, Third Edition-Functional Academics Scale (ABAS-FA) and Child Behavior Checklist (CBCL) Total Competency Scale. Results: Parent ratings of ABAS-FA were at or above normative expectations, while ratings across CBCL Competency Scales were lower than normative expectations. Socioeconomic status (SES), age, and race were consistent predictors of parent ratings (higher SES, older age, and Caucasian race were associated with better functioning). Number of surgeries did not add significantly to academic ratings but did significantly contribute to ratings of social and activity participation. Patients with more surgeries were rated with lower functioning in these domains. Conclusions: Findings do not support a connection between number of surgeries and later ratings of academic functioning but do support a connection to social and activity involvement. Recommendations for conducting direct studies of the connection between surgeries and academic functioning as well as clinical considerations for surgeries and impact on social and activity involvement are discussed.