bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of pre‐operative radiotherapy on long‐term outcomes among women with Stage IB1 to IIB cervical squamous cell carcinoma
Authors: Liu Ping , Dai Encheng , Li Weili , He Fangjie , Yang Rui , Bin Xiaonong , Lang Jinghe , Chen Chunlin 
Published: November 2020

AbstractObjectiveTo compare long‐term outcomes between pre‐operative radiotherapy followed by open surgery and direct open surgery among women with Stage IB1–IIB cervical squamous cell carcinoma.MethodsA multicenter retrospective cohort study among women with Stage IB1–IIB cervical squamous cell carcinoma who underwent open surgery either directly (SD group) or with pre‐operative radiotherapy (PR group) in China 2004–2016. Five‐year overall survival (OS) and disease‐free survival (DFS) between the two groups were compared by Kaplan–Meier methods and multivariate Cox regression.ResultsOverall, 8385 women with Stage IB1–IIB were included (PR group, n = 447; SD group, n = 7938). Five‐year OS and DFS was significantly lower in the PR than in the SD group (OS: 81.7% vs 91.6%, P < 0.001; DFS: 76.3% vs 86.7%, P < 0.001). As compared with direct surgery, pre‐operative radiotherapy was an independent risk factor for 5‐year OS (adjusted hazard raio [aHR], 1.75; 95% confidence interval [CI], 1.34–2.30) and DFS (aHR, 1.37; 95% CI, 1.09–1.73) by multivariate Cox regression. Sensitivity analyses confirmed the findings.ConclusionAmong women with Stage IB1–IIB cervical squamous cell carcinoma, outcomes were found to be worse for those undergoing pre‐operative radiotherapy followed by open surgery than for those undergoing direct open surgery.
Association of pretreatment SUVmax of cervix and SCC‐antigen with FIGO2018 stage in Stage IIB–IVB squamous cervical cancer and relationship to prognosis
Authors: Shou Huafeng , Yasuo Yoshioka , Yuan Shuhui , Lou Hanmei , Ni Juan 
Published: November 2020

AbstractObjectiveTo evaluate the association of pretreatment maximum standardized 18F‐fluorodeoxyglucose uptake value (SUVmax) of cervix and serum squamous cell carcinoma antigen (SCC‐ag) with FIGO2018 stage and prognosis among women with Stage IIB–IVB squamous cervical cancer.MethodsRetrospective study of 116 women with FIGO2018 Stage IIB–IVB cervical cancer treated in Hangzhou, China, 2013–2015. The relationship between pretreatment SUVmax or SCC‐ag and prognostic factors was evaluated by univariate and multivariate analyses.ResultsWomen were stratified by mean SUVmax and mean SCC‐ag. There was a significant difference between low (<12.9) and high (≥12.9) SUVmax groups in menopause (P = 0.004), FIGO2018 stage (P = 0.015), and survival rate (P < 0.001). The low group had better overall and progress‐free survival by Kaplan–Meier evaluation (both P = 0.022). High SCC‐ag (≥14.6 ng/mL) was associated with FIGO2018 stage (P = 0.038) and distant metastasis (P = 0.011). There was a significant correlation between SUVmax and serum SCC‐ag (P = 0.026). In multivariate Cox regression analyses, FIGO2018 stage (P = 0.019) and SUVmax of cervix (P = 0.015) were independent predictors of poor outcome in squamous cervical cancer.ConclusionBoth SUVmax of cervix and SCC‐ag were associated with FIGO2018 stage in squamous cervical cancer. Pretreatment high SUVmax of cervix and advanced FIGO2018 stage might indicate a poor prognosis.
Silencing of lncRNA Gm14461 alleviates pain in trigeminal neuralgia through inhibiting astrocyte activation
Authors: Cai Jun , Yan Yi , Zhang Daying , Zhu Mengye , Wang Zhijian , Zhang Xuexue , Xu Mu 
Published: November 2020

AbstractOur previous study showed that silencing of lncRNA Gm14461 alleviated pain in a murine model of trigeminal neuralgia (TN), but the molecular mechanism remains not fully understood. Evidence indicates that astrocyte activation and autophagy are involved in the development of TN. Herein, this study aimed to elucidate whether the pain‐relief effect of Gm14461 silencing in TN involved regulation of astrocyte activation and autophagy. A murine model of TN was induced by chronic constriction injury of the infraorbital nerve surgery. The mechanical withdrawal threshold (MWT) was measured to assess the analgesic effect of Gm14461 silencing. Mouse astrocytes were treated with lipopolysaccharide (LPS) as a cell model. Astrocyte activation was evaluated by glial fibrillary acidic protein (GFAP) immunofluorescence and western blot analysis of GFAP. Autophagy was evaluated by LC3 immunofluorescence and western blot analysis of autophagy‐related proteins. The results showed that Gm14461 silencing increased MWT value in TN model mice. Meanwhile, Gm14461 silencing inhibited astrocyte activation and enhanced autophagy in both TN mice and LPS‐treated astrocytes. The enhancement of autophagy by Gm14461 silencing involved the activation of the AMPK signaling and the suppression of the Akt/mTOR signaling. Collectively, the analgesic effect of Gm14461 silencing in TN was related to attenuation of astrocyte activation via enhancement of autophagy.
The lncRNA MEG3/miR‐16‐5p/VGLL4 regulatory axis is involved in etoposide‐induced senescence of tumor cells
Authors: Tao Ye , Yue Peipei , Miao Yongnan , Gao Shuting , Wang Biao , Leng Sean X. , Meng Xin , Zhang Haiyan 
Published: November 2020

AbstractBackgroundThe senescence of tumor cells is an important tumor suppressor mechanism. The present study aimed to investigate the role of long non‐coding RNA (lncRNA) MEG3 (maternally expressed gene 3) in the senescence process of tumor cells and its potential molecular mechanism by competitively binding with microRNA miR‐16‐5p to regulate the expression of VGLL4 (encoding vestigial like family member 4).MethodsWe used etoposide to construct senescence models of tumor cells. The degree of cellular senescence was detected by senescence‐associated β‐galactosidase, cell cycle and senescence‐associated secretory phenotype. The expression of lncRNA MEG3, miR‐16‐5p and VGLL4 in senescent or non‐senescent cells was evaluated using a quantitative real‐time reverse transcriptase‐PCR (qRT‐PCR) or western blotting. Dual luciferase reporter assays were used to detect the binding of miR‐16‐5p to lncRNA MEG3 and VGLL4. The mRNA and protein expression levels of senescence‐related markers (p53, p21 and p16) were detected using qRT‐PCR or western blotting.ResultsCompared to the control group, the expression of lncRNA MEG3 and VGLL4 was significantly up‐regulated in senescent cells. Knockdown of lncRNA MEG3 and VGLL4 reduced the degree of senescence and the expression of p21 and p16. lncRNA MEG3 interfered with the expression of miR‐16‐5p in senescent A549 and MCF‐7 cells. The expression of VGLL4 was regulated by miR‐16‐5p in senescent A549 and MCF‐7 cells. lncRNA MEG3 participated in the senescent progress of tumor cells induced by etoposide via the miR‐16‐5p/VGLL4 axis.ConclusionsThe present study has confirmed the regulatory role of the lncRNA MEG3/miR‐16‐5p/VGLL4 axis in the low‐dose etoposide‐induced tumor cell senescence model, which has potential clinical application with respect to treating malignant tumors.
GBE1‐related disorders: Adult polyglucosan body disease and its neuromuscular phenotypes
Authors: Souza Paulo Victor Sgobbi , Badia Bruno Mattos Lombardi , Farias Igor Braga , Pinto Wladimir Bocca Vieira de Rezende , Oliveira Acary Souza Bulle , Akman Hasan Orhan , DiMauro Salvatore 
Published: November 2020

AbstractAdult polyglucosan body disease (APBD) represents a complex autosomal recessive inherited neurometabolic disorder due to homozygous or compound heterozygous pathogenic variants inGBE1gene, resulting in deficiency of glycogen‐branching enzyme and secondary storage of glycogen in the form of polyglucosan bodies, involving the skeletal muscle, diaphragm, peripheral nerve (including autonomic fibers), brain white matter, spinal cord, nerve roots, cerebellum, brainstem and to a lesser extent heart, lung, kidney, and liver cells. The diversity of new clinical presentations regarding neuromuscular involvement is astonishing and transformed APBD in a key differential diagnosis of completely different clinical conditions, including axonal and demyelinating sensorimotor polyneuropathy, progressive spastic paraparesis, motor neuronopathy presentations, autonomic disturbances, leukodystrophies or even pure myopathic involvement with limb‐girdle pattern of weakness. This review article aims to summarize the main clinical, biochemical, genetic, and diagnostic aspects regarding APBD with special focus on neuromuscular presentations.
Ocular Blood Flow Measurements in Diabetic Retinopathy Using 3D Pseudocontinuous Arterial Spin Labeling
Authors: Wang Huihui , Sun Jiao , Li Jing , Li Hongyang , Wang Yanling , Wang Zhenchang 
Published: November 2020

BackgroundDistinguishing between the two broad categories of diabetic retinopathy (DR), nonproliferative DR (NPDR) and proliferative DR (PDR), is significant, as the therapeutic strategies for each are completely different.PurposeTo characterize the ocular blood flow (OBF) of DR patients and evaluate the potential utility of OBF values in categorizing DR.Study TypeProspective.SubjectsA total of 41 DR patients (82 eyes) were recruited in our study. Group 1 comprised 48 eyes with NPDR, and Group 2 comprised 34 eyes with PDR.Field Strength/Sequence3D pseudocontinuous arterial spin labeling (3D‐pcASL) with two postlabeling delays (PLDs) was acquired at 3.0T MR.AssessmentOBF values were independently obtained by two doctors from the OBF map.Statistical TestsOBF values and clinical characteristics were compared between the groups using two‐sample t‐tests and chi‐square tests. Receiver operating characteristic (ROC) curves were obtained, and the area under the curve (AUC) was calculated. The consistency of OBF values reported by the two doctors was evaluated using the intraclass correlation coefficient (ICC).ResultsOBF values at PLDs of 1.5 seconds and 2.5 seconds were significantly lower in Group 2 than in Group 1 (P < 0.05 for both PLDs). The OBF values of Group 2 showed a greater increase than those of Group 1 from PLD 1.5 to 2.5 seconds. The AUC of OBF at the 1.5 seconds PLD was 0.90, with a cutoff of 7.73 mL/min/100 g, and the AUC of the OBF at the 2.5 seconds PLD was 0.75, with a cutoff of 8.44 mL/min/100 g. The ICC between the two observers was 0.844 for the OBF at 1.5 seconds PLD and 0.872 for the OBF at 2.5 seconds PLD.Data ConclusionPDR can be differentiated from NPDR by the value of OBF as measured by 3D‐pcASL.Level of Evidence1Technical Efficacy Stage1
Pseudo Split Gate In0.53Ga0.47As/InP Hetero‐Junction Tunnel FET: Design and Analysis
Authors: Haris Mohd , Loan Sajad A. , Mainuddin  
Published: November 2020

AbstractIn this work, we present the design and simulation of a novel structure of In0.53Ga0.43As/InP based hetero junction tunnel field effect transistor (HTFET). The proposed HTFET employs two gates: the conventional main gate and a pseudo split gate (PSG) at the drain side. The PSG is placed at the top of the drain region with the same equivalent oxide thickness (EOT) and work function as that of the main gate at an optimized separation from gate electrode. The PSG is not an active gate and it is not connected to either VDD or gate voltage. Two dimensional simulation study has revealed that the proposed device suppresses ambipolar current by ~10 orders of magnitude as compared to a HTFET without overlap and by >7 orders as compared to overlapping gate on drain HTFET (OGD‐HTFET). The PSG‐based HTFET (PSG‐HTFET) also exhibits lesser total gate capacitance as compared to OGD TFET. The proposed PSG‐HTFET offers much better ambipolar suppression even at higher drain doping and lower EOT, as compared to OGD‐HTFET. Further, the PSG‐HTFET exhibits 50% and 40% lesser fall and rise propagation delays respectively as compared to the OGD‐HTEFT. Further, the voltage overshoot and undershoot have also been suppressed in the proposed PSG‐HTFET. The scalability analysis shows that the PSG‐HTFET has better scalability in terms of ambipolar suppression, total gate capacitance, and propagation delays.
To be or not to be consistent? The role of friendship and group‐targeted perspective in managers' allocation decisions
Authors: Derfler‐Rozin Rellie , Sherf Elad N. , Chen Gilad 
Published: November 2020

SummaryAdopting a justice enactment perspective, we explore managers' consistent versus inconsistent application of existing rules in allocation decisions. We propose that when managers form friendship relationships with their employees, they are likely to experience greater tensions when fulfilling their managerial duties as resource allocators. On the one hand, managers may wish to deviate from the rules to benefit an employee who is also a friend. On the other hand, benefiting one employee (but not others) might lead to tensions in managers' friendships with other employees. We further argue that the extent to which managers adopt a group‐targeted perspective affects the resolution of this tension such that, from such a perspective, they are more likely to perceive consistent application of existing rules (vs. deviating from them) as fairer. We find support for our predictions across a field study and an experimental study. We discuss implications of our findings for literatures on justice enactment, allocation decisions, and workplace friendships.
An investigation of the antidepressant‐like effect of Jiaotaiwan in rats by nontargeted metabolomics based on ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
Authors: Jiao Ziyi , Zhao Huan , Huang Wei , Liang Ru , Liu Yijia , Li Zhu , Li Lin , Xu Yilan , Gao Shuming , Gao Shan , Li Yubo , Yu Chunquan 
Published: November 2020

AbstractDepression is a mental disorder characterized by persistent unhappiness, lack of interest, with cognitive and sleep disorders. Jiaotaiwan is a traditional Chinese medicine for the treatment of insomnia and depressive‐like symptoms. In this study, the major chemical components in Jiaotaiwan were qualitatively analyzed using ultra high performance liquid chromatography quadrupole time‐of‐flight mass spectrometry, and a model of depression in rats was subsequently established with chronic unpredictable mild stress followed by Jiaotaiwan intervention. Next, the metabolic profile of rat serum samples was analyzed using nontargeted metabolomics, wherein changes in the metabolites in serum samples before and after Jiaotaiwan administration were measured by multiple statistical approaches. Principal component analysis and partial least squares discriminant analysis indicated that the Jiaotaiwan treatment improved the metabolic phenotype depression. Moreover, the heatmap analysis identified the most important ten biomarkers involved in depression. According to the pathway analysis, the therapeutic effect of Jiaotaiwan on depression may involve the regulation of amino acid metabolism, glycerophospholipid metabolism, and energy metabolism. These findings help us understand the pathogenesis of depression in‐depth, and discover targets for clinical diagnosis and treatment. And it also lays a foundation for the use of Jiaotaiwan as an antidepressant agent.
A Comparison of Triamcinolone Acetonide Econazole Cream and Nystatin Suspension in Treatment of Otomycosis
Authors: Chen Qingguo , Chu Hanqi , Tao Yanling , Peng Liyan , Zhou Liangqiang , Liu Lei , Wu Xiaohui 
Published: November 2020

Objectives/HypothesisTo compare the efficacy and adverse effects of triamcinolone acetonide econazole cream and nystatin suspension in the treatment of otomycosis, and to determine the clinical features, predisposing factors, and etiology of otomycosis.Study DesignA prospective study.MethodsA prospective clinical trial was conducted on 786 patients diagnosed with otomycosis. The study population was randomly divided into two treatment groups of triamcinolone acetonide econazole cream (TAEC) and nystatin suspension in a 1:1 ratio. After clearing all fungal deposits in the external auditory canal, the antimycotic drugs were locally applied for at least 2 weeks. The efficacy and adverse effects were compared between the two antifungal reagents by statistical analysis. Meanwhile, patient clinical data were collected to find out the clinical features, predisposing factors, and etiology.ResultsPruritis was the most common symptom and Aspergillus niger was the leading fungal pathogen. There was high association (44.5%) of otomycosis with a history of unclean ear picking. The cure rate was 97.6% in the TAEC group and 73.5% in the nystatin group (P < .01). Treatment with TAEC resulted in 2.4% of patients complaining of discomforts (irritant dermatitis, otalgia, or headache) versus 59.8% of patients complaining discomforts treated with nystatin (P < .01). The residue rate of antifungals was 1.9% in the TAEC group and 89.9% in the nystatin group (P < .01) at the end of treatment.ConclusionsThoroughly cleaning of the external auditory canal followed by local use of TAEC under endotoscope is an effective, convenient, and well‐tolerated treatment for otomycosis.Level of Evidence1 Laryngoscope, 131:E1640–E1646, 2021
The Potential Protective Effects of Statins in Chronic Rhinosinusitis: A Case–Control Study
Authors: Gilani Sapideh , Bhattacharyya Neil 
Published: November 2020

Objectives/HypothesisTo determine the potential protective effect of prior statin use on the subsequent diagnosis of chronic rhinosinusitis (CRS).Study DesignRetrospective, case‐control.MethodsElectronic medical records for all patients seen in the otolaryngology clinic in 2019 and receiving a diagnosis of CRS were reviewed for the presence or absence of active prior statin use within 365 days of the visit. Similarly, prior statin use in a control group of patients without any diagnosis of CRS was also determined. Statin exposure in CRS patients was compared to statin exposure in control patients with 1:2 matching on age and sex with chi‐square and odds ratios were computed.ResultsIn 2019, 3655 patients (mean age, 52.9 years, 56.4% female) were identified with a diagnosis of chronic rhinosinusitis versus 41,636 patients without any diagnosis of CRS. All chronic rhinosinusitis patients were successfully matched to 7310 controls. 6.3% of CRS patients (229 patients) had prior statin use, versus 8.5% (624 patients) of control patients. The average mean duration of statin use prior to visit was not significantly different between CRS and control patients (mean days, 202.3 days versus 205.6 days, respectively; P = .697). The presence of a statin medication in use was associated with a significant protective effect against a subsequent diagnosis of CRS with and odds ratio for CRS diagnosis of 0.716 (95% confidence interval, 0.612–0.838) in those patients taking a statin medication (P < .001).ConclusionsThe use of a statin medication was associated with a significant reduction in subsequent diagnosis of chronic rhinosinusitis.Level of Evidence3 Laryngoscope, 131:E1431–E1433, 2021
Trait‐based sediment retention and runoff control by herbaceous vegetation in agricultural catchments: A review
Authors: Kervroëdan Léa , Armand Romain , Rey Freddy , Faucon Michel‐Pierre 
Published: November 2020

AbstractSoil degradation by concentrated runoff and soil erosion induces major environmental and economic damages, notably in agricultural areas under temperate climates. The use of herbaceous vegetation aims to increase the hydraulic resistance and thus reduce runoff and soil erosion while retaining sediments on site. However, the identification of the most suitable species to mitigate runoff is often specific to a phytogeographical territory and hampered by the intraspecific variability, which reduces the transposition of a solution to other territories and the ability to quantify the effects of the vegetation. Using a plant trait‐based approach allows understanding and characterising the direct effects of the vegetation on runoff and soil erosion mitigation as well as on the sediment retention increase. Here, we review the influence of plant aboveground functional types and traits of herbaceous vegetation on the hydraulic resistance and sediment retention and the contentious effects of the functional diversity on the hydraulic resistance and sediment retention, within agricultural catchments. Using this knowledge, we propose applications of the trait‐based approach to design and manage herbaceous hedges for sediment retention and soil erosion control. This review synthesises recent advances regarding the effects of the functional traits on runoff and sediment retention and defines a trait‐based selection method of the plant species for runoff and soil erosion control.
The role of vitamin D in head and neck cancer
Authors: Izreig Said , Hajek Michael , Edwards Heather A. , Mehra Saral , Sasaki Clarence , Judson Benjamin L. , Rahmati Rahmatullah W. 
Published: November 2020

AbstractObjectiveHead and neck squamous cell carcinoma (HNSCC) describes a set of malignancies of the head and neck that continue to inflict considerable morbidity and mortality. Because HNSCC often presents at an advanced stage, patients frequently undergo intensive multi‐modal therapy with an intent to cure. Vitamin D is a precursor to the biologically active hormone calcitriol which governs bone and calcium physiology that is obtained from diet and UV‐B exposure. Vitamin D is known to have pleiotropic effects on health and disease. In this review, we examine the role of vitamin D in cancer with emphasis on HNSCC and discuss potential avenues for further research that might better elucidate the role of vitamin D in the management of HNSCC.Review methodsA review of MEDLINE database indexed literature concerning the role and biology of vitamin D in HNSCC was conducted, with special consideration of recently published work and research involving immunobiology and HNSCC.ConclusionsThe available evidence suggests that vitamin D may play a role in protecting against HNSCC, particularly in persons who smoke, although conflicting and limited data exists. Promising initial work encourages the pursuit of further study.Implications for practiceThe significant morbidity and mortality that HNSCC brings warrants continued research in available and safe interventions that improve patient outcomes. With the rise of immunotherapy as an effective modality for treatment, continued research of vitamin D as an adjunct in the treatment of HNSCC is supported.