bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of Autism Spectrum Disorder (ASD) Diagnosis Among Latino Parents and Caregivers
Authors: Florindez Lucia , Como Dominique , Florindez Daniella , Cermak Sharon , Duker Leah 
Published: November 2019

Abstract
Date Presented 04/04/19
Disparities exist regarding ASD diagnosis for Latino children. Findings from narrative interviews exploring how Latino parents and caregivers perceive ASD diagnosis will help illuminate how health information is communicated within this at-risk population and inform the development of future targeted education and intervention programs.
Primary Author and Speaker: Lucia Florindez
Additional Authors and Speakers: Dominique Como, Daniella Florindez, Sharon Cermak, Leah Duker
Sensory Processing Predicts Social Responsiveness in Adults With Autism
Authors: Crasta Jewel , Davies Patricia , Gavin William 
Published: November 2019

Abstract
Date Presented 04/04/19
This study evaluated the relationship between sensory processing and social responsiveness in young adults with ASD and age-matched neurotypical controls. Compared to controls, young adults with ASD had significant differences on all four quadrants of the sensory profile. However, low registration and sensory gating (the ability to filter irrelevant information) appear to be key predictors of social responsiveness.
Primary Author and Speaker: Jewel Crasta
Additional Authors and Speakers: Patricia Davies
Contributing Authors: William Gavin
OT Intervention for Survivors of Human Trafficking
Authors: Cerny Shana , Maassen Alexya , Crook Krista 
Published: November 2019

Abstract
Date Presented 04/05/19
The purpose of this report is to outline the OT process for survivors of human trafficking (n=6) living in community transitional housing. After 12 weeks of intervention, all clients reported an overall improvement in performance and satisfaction in their prioritized areas of occupation. There was a significant difference in the evaluation and re-evaluation scores of performance and satisfaction (p= 0.04).
Primary Author and Speaker: Shana Cerny
Contributing Authors: Alexya Maassen, Krista Crook
Children With Autism Spectrum Disorder (ASD) Process Action Imitation Differently Depending on Motor Difficulties: Implications for Individualized Therapy
Authors: Kilroy Emily , Butera Christiana , Zeisler Cristin , Harrison Laura , Cermak Sharon , Aziz-Zadeh Lisa 
Published: November 2019

Abstract
Date Presented 04/06/19
This course highlights developments and findings in a neuroscience study as they relate to OT for children and adolescents with ASD. The presenters discuss findings from an ongoing functional magnetic resonance imaging (fMRI) study that investigates the neural basis of how children with ASD imitate social and motor stimuli. Study results can be used to inform clinical approaches for research-informed client-centered OT interventions.
Primary Author and Speaker: Emily Kilroy
Additional Authors and Speakers: Christiana Butera
Contributing Authors: Cristin Zeisler, Laura Harrison, Sharon Cermak, Lisa Aziz-Zadeh
Community Interventions for Families With Children With Intellectual or Developmental Disabilities: A Systematic Review
Authors: Romaniak Holly , Hladik Elisabeth , Ausderau Karla 
Published: November 2019

Abstract
Date Presented 04/06/19
A systematic review was conducted to evaluate the effectiveness of public space interventions promoting community engagement for families with children with intellectual and developmental disabilities. Findings suggest a dearth of research and limited evidence supporting current effectiveness. Further research and collaboration among OTs, stakeholders, and public institutions are needed to increase opportunities for families' meaningful participation in the community.
Primary Author and Speaker: Holly Romaniak
Additional Authors and Speakers: Elisabeth Hladik, Karla Ausderau
Cocalibrated Functional Score and Subsequent Post-Acute-Care (PAC) Utilization
Authors: Li Chih-Ying , Karmarkar Amol , Kuo Yong-Fang , Hass Allen , Ottenbacher Kenneth 
Published: November 2019

Abstract
Date Presented 04/06/19
This study is the first examining the relationship between cocalibrated functional score and subsequent PAC utilization for Medicare beneficiaries. Examining functional scores across PAC settings for patients with stroke, lower extremity joint replacement, and hip/femur fracture allows OTs to estimate clients' needs for postacute services.
Primary Author and Speaker: Chih-Ying Li
Additional Authors and Speakers: Amol Karmarkar, Yong-Fang Kuo, Allen Hass, Kenneth Ottenbacher
Nietzsche's Transformation of the Problem of Pessimism in Human, All Too Human
Authors: Jenkins Scott 
Published: November 2019

Abstract
In Book I of Human, All Too Human, Nietzsche maintains that optimism and pessimism are both outdated because no judgment concerning the value of life gains support from the naturalistic philosophy that he now embraces. I show that Nietzsche's repudiation of optimism and pessimism rests on a distinction between theoretical and evaluative judgments that originates in his reading of Eugen Dühring's The Value of Life. While Nietzsche now maintains that theoretical judgments do not justify any position on the value of life, he still holds that a person who sees life accurately will exhibit the practical world-denial characteristic of the pessimist because such a person will apprehend what Nietzsche calls the “goallessness” of humanity. I formulate three readings of this notion and argue that Nietzsche is developing the Schopenhauerian claim that all goals of action are, in truth, given to us by nature. I conclude by showing that while Nietzsche's understanding of pessimism remains Schopenhauerian in this book he transforms the problem of pessimism by locating it within the temperament of human beings.
Nietzsche on the Origin of Conscience and Obligation
Authors: Snelson Avery 
Published: November 2019

Abstract
The second essay of Nietzsche's Genealogy of Morality (GM) offers a naturalistic and developmental account of the emergence of conscience, a faculty uniquely responsive to remembering and honoring obligations. This article attempts to solve an interpretive puzzle that is invited by the second essay's explanation of nonmoral obligation, prior to the capacity to feel guilt. Ostensibly, Nietzsche argues that the conscience and our concept of obligation originated within contractual (“creditor-debtor”) relations, when creditors punished delinquent debtors (GM II:5). However, this interpretation, which I call the contractualist reading, is incoherent and subject to an insoluble bootstrapping problem. I argue instead that Nietzsche provides two accounts of nonmoral obligation in the second essay, and that the conscience originated in the morality of custom to track rule prohibitions (“I will nots” [GM II:3]), which Nietzsche conceives of as involuntary or reciprocal obligations that, unlike contractual debts, do not require the making of promises.
Geochemistry and Geophysics of Iron Oxide-Apatite Deposits and Associated Waste Piles with Implications for Potential Rare Earth Element Resources from Ore and Historical Mine Waste in the Eastern Adirondack Highlands, New York, USA
Authors: Taylor Ryan D. , Shah Anjana K. , Walsh Gregory J. , Taylor Cliff D. 
Published: November 2019

Abstract
The iron oxide-apatite (IOA) deposits of the eastern Adirondack Highlands, New York, are historical high-grade magnetite mines that contain variable concentrations of rare earth element (REE)-bearing apatite crystals. The majority of the deposits are hosted within sodically altered Lyon Mountain granite gneiss, although some deposits occur within paragneiss, gabbro, anorthosite, or potassically altered Lyon Mountain granite gneiss. The IOA deposits and the waste and/or tailings piles associated with them have potential as an unconventional resource for REEs. Reprocessing of these piles would have the advantage of partial recycling of the waste material to produce a set of critical elements.
Thirty-four ore, nine rock, 25 waste-pile, and four tailings-pile samples were collected and analyzed for major, minor, and trace elements. At the tailings- and waste-pile sites, composite samples were collected by combining 30 to >50 subsamples randomly distributed over each pile. The total REE content of the waste and tailings piles varied from approximately 10 to 22,000 ppm, whereas the ore sample concentrations ranged from approximately 15 to 48,000 ppm total REEs. A positive correlation exists between the total REE content of ore and its associated waste pile. Median light REE/heavy REE values were 2.14 for waste/tailings piles and 2.25 for ore, which is a substantial relative enrichment in the heavy REEs in comparison to many developed REE mines, such as the mined carbonatites of Bayan Obo, China, and Mountain Pass, California. Importantly, the ore and waste samples are significantly enriched in both Y and Nd compared to other REEs in the samples. Other minor components such as Th are also elevated. Airborne radiometric surveys show large positive eTh and eU anomalies corresponding to tailings piles.
Although it is a limited data set, geochemical data of unaltered and altered host rocks suggest a speculative new model for IOA ore formation in the Adirondack Highlands that is consistent with the geology and previously published data. The ferroan ore-hosting Lyon Mountain granite gneiss underwent localized potassic alteration that enriched the altered rock in Fe, REEs, Th, and other metals. A later sodic alteration event affected the previously potassically altered Lyon Mountain granite gneiss, which increased rock porosity and remobilized Fe, REEs, and other elements from the host rock into the iron ore seams. The sodic fluids responsible for ore formation were enriched in F and Cl.
Nurses’ perceptions of hazards to patient safety in the intensive care units during a nursing staff shortage
Authors: Chuang Sheuwen , Maguire Laura M.D. , Hsiao Shu-Tai , Ho Yun-Hsien , Tsai Su-Fen 
Published: November 2019

Objective: Nursing shortage in acute care had shown a negative impact on patient safety and nurses. This study determines nurses’ perceptions of hazards affecting patient safety in the intensive care units (ICUs) of a private regional hospital.Methods: An initial focus group was used to explore nurses’ sense of, and experiences with, hazards affecting patient safety in daily care. This data aided in developing a structured questionnaire to survey ICU nurses. Nonparametric test and t test were applied for inference analysis.Results: Response rate was 78% with average age of respondents 28. Sixty-three hazards were identified and segmented into four domains. Hazards in the Team/Communication domain were the highest risks commonly perceived by all ICU nurses. Less-experienced nurses were more concerned about unfamiliar procedures/equipment and unexpected conditions from both Administration/Maintenance and Patients/Family domains than senior nurses.Conclusions: The study highlights the complexity of nursing care and hidden nursing management issues, as well as suggests that nurses’ perceptions of hazards to patient care could help understand important difference between nursing staff to more specifically address variations to improve the situation.
The Impact of Transit Times on the Detection of Bacterial Pathogens in Blood Cultures: A College of American Pathologists Q-Probes Study of 36 Institutions
Authors: Procop Gary W. , Nelson Suzanne K. , Blond Barbara J. , Souers Rhona J. , Massie Larry W. 
Published: November 2019

Context.—
Consolidation of clinical microbiology laboratory services has resulted in extended transit time for blood cultures from service points distant from the laboratory. Sepsis is critical; delays in identification of etiologic agents of diseases could adversely impact patient care.

Objective.—
To examine the effect of total preanalytic time and blood culture volume on the instrument time-to-detection for bacterial pathogens in blood cultures. A secondary objective was to obtain relevant blood culture information by questionnaire.

Design.—
Participants in this Q-Probes study recorded date, time, and volume information for the first 50 positive blood cultures collected during the 12-week study period. Additional information regarding blood culture collection practices was obtained through questionnaire.

Results.—
Prolonged overall time-to-detection was secondary to prolonged preanalytic time, particularly prolonged transit time, rather than slower organism growth once bottles were placed on the instrument. Among 1578 blood cultures, the overall time from collection to positive result was significantly less for blood cultures collected on-site than for off-site locations. Most institutions lack sufficient training programs and do not monitor preanalytic time metrics associated with blood cultures. Four hundred fifty-six of the 1580 blood cultures with blood volume adequacy reported (28.9%) were inadequately filled.

Conclusions.—
Overall process time (specimen collection to positive blood culture detection) is predicted to be higher for blood cultures collected off-site. Transit time is a variable that can be reduced to decrease overall time to detection. Thus, improved training and closer attention to preanalytic metrics associated with blood cultures could decrease hospital stays and mortality rates.
Preparation, thermal stability and electrical transport properties of vaesite, NiS2
Authors: Ferreira Helena M. , Lopes Elsa B. , Malta José F. , Ferreira Luís M. , Casimiro Maria H. , Santos Luís , Pereira Manuel F.C. , Pereira Gonçalves Antonio 
Published: November 2019

Vaesite, a nickel chalcogenide with NiS2 formula, has been synthetized and studied by theoretical and experimental methods. NiS2 was prepared by solid-state reaction under vacuum and densified by hot-pressing, at different consolidation conditions. Dense single-phase pellets (relative densities >94%) were obtained, without significant lattice distortions for different hot-pressing conditions. The thermal stability of NiS2 was studied by thermogravimetric analysis. Both as-synthetized and hot-pressed NiS2 have a single phase nature, although some hot-pressed samples had traces of the sulfur deficient phase, Ni1-xS (<1%vol), due to the strong desulfurization at T > 340 °C. The electronic band structure and density of states were calculated by Density Functional Theory (DFT), indicating a metallic behavior. However, the electronic transport measurements showed p-type semiconductivity for bulk NiS2, verifying its characteristic behavior has a Mott insulator. The consolidation conditions strongly influence the electronic properties, with the best room-temperature Seebeck coefficient, electrical resistivity and power factor being 182 µVK−1, 2,257 µΩ m and 14.1 µWK−2 m−1, respectively, pointing this compound as a good starting point for a new family of thermoelectric materials.
Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data
Authors: Nicolussi Arianna , Belardinilli Francesca , Silvestri Valentina , Mahdavian Yasaman , Valentini Virginia , D’Inzeo Sonia , Petroni Marialaura , Zani Massimo , Ferraro Sergio , Di Giulio Stefano , Fabretti Francesca , Fratini Beatrice , Gradilone Angela , Ottini Laura , Giannini Giuseppe , Coppa Anna , Capalbo Carlo 
Published: November 2019

Background
Genetic testing for BRCA1/2 germline mutations in hereditary breast/ovarian cancer patients requires screening for single nucleotide variants, small insertions/deletions and large genomic rearrangements (LGRs). These studies have long been run by Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA). The recent introduction of next-generation sequencing (NGS) platforms dramatically improved the speed and the efficiency of DNA testing for nucleotide variants, while the possibility to correctly detect LGRs by this mean is still debated. The purpose of this study was to establish whether and to which extent the development of an analytical algorithm could help us translating NGS sequencing via an Ion Torrent PGM platform into a tool suitable to identify LGRs in hereditary breast-ovarian cancer patients.

Methods
We first used NGS data of a group of three patients (training set), previously screened in our laboratory by conventional methods, to develop an algorithm for the calculation of the dosage quotient (DQ) to be compared with the Ion Reporter (IR) analysis. Then, we tested the optimized pipeline with a consecutive cohort of 85 uncharacterized probands (validation set) also subjected to MLPA analysis. Characterization of the breakpoints of three novel BRCA1 LGRs was obtained via long-range PCR and direct sequencing of the DNA products.

Results
In our cohort, the newly defined DQ-based algorithm detected 3/3 BRCA1 LGRs, demonstrating 100% sensitivity and 100% negative predictive value (NPV) (95% CI [87.6–99.9]) compared to 2/3 cases detected by IR (66.7% sensitivity and 98.2% NPV (95% CI [85.6–99.9])). Interestingly, DQ and IR shared 12 positive results, but exons deletion calls matched only in five cases, two of which confirmed by MLPA. The breakpoints of the 3 novel BRCA1 deletions, involving exons 16–17, 21–22 and 20, have been characterized.

Conclusions
Our study defined a DQ-based algorithm to identify BRCA1 LGRs using NGS data. Whether confirmed on larger data sets, this tool could guide the selection of samples to be subjected to MLPA analysis, leading to significant savings in time and money.
Characterization of preferential flow in soils near Zarqa river (Jordan) using in situ tension infiltrometer measurements
Authors: Rahbeh Michel 
Published: November 2019

Background
The Zarqa River (ZR) is located in the northern part of Jordan and supplies King Talal Dam (KTD). The streamflow that discharges into KTD is composed of treated wastewater from the Khirbat Es-Samra water treatment plant (KTP) and runoff generated during the winter season. Thus, during the summer, the streamflow of the ZR is dominated by effluent from the KTP. Due to the severe scarcity of water in Jordan, a portion of the streamflow is utilized for irrigated agriculture in the ZR valley, located between the KTP and KTD. The groundwater in the vicinity of the ZR is vulnerable to contamination—a risk that may be exacerbated by the potential occurrence of preferential flow (PF). Therefore, the PF in the soils near the ZR should be carefully considered.

Methods
The macropore flux fraction (Qmacro) and macroscopic capillary length (λc) were determined from in situ measurements using a tension infiltrometer equipped with an infiltration disc with a diameter of 20 cm. The macropore was defined as the pore size that drains at a tension of less than —-3— cm. The λc less than 80 mm was considered to be an indication of PF. The measurements were taken at 69 sites along the ZR between the KTP and KTD. At each measurement site, the soil organic matter content (OM) and soil texture were determined using a composite soil sample obtained by excavating the soil beneath the infiltration disc to a depth of 10 cm.

Results
The data was split into two groups: the matrix flow group (MF), which includes data associated with λc > 80 mm, and the PF group, which includes data associated with λc < 80 mm. The Qmacro values of 0.67 and 0.57, respectively, for PF and MF were significantly different at p < 0.01 (t-test). The flow rates at h=0 were generally well associated with λc, as attested to by a significant difference between the averages of PF (57.8 mm/hr) and MF (21.0 mm/hr) at p < 0.01 (t-test). The OM was positively associated with PF. This was statistically confirmed by a t-test at p < 0.01. The average sand and clay contents of PF and MF were not statistically different. Analysis of the ratio of Soil Organic Carbon (SOC) to clay showed that the average SOC/clay of the PF (14%) was larger than that of the MF (13.3%). After the exclusion of soils with clay content less than 8%, the differences between the SOC/clay averages of PF (9.8%) and MF (7.5%) were significant at p < 0.05, as shown by a WM-test.

Conclusion
The OM was positively associated with PF. Soil texture—and clay content in particular—influenced the λcvalues. However, the association of clay content with PF was not statistically significant. Consideration of the SOC/clay ratio showed that the tendency toward PF increases as the complexation of the clay content increases. This was most obvious in soils with a clay content of greater than 8% and SOC/clay of approximately 10%. The OM either influences or is inter-correlated with the processes responsible for the formation of macropores.
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer
Authors: Li Yongfu , Wei Yuhan , Tang Wenjun , Luo Jingru , Wang Minghua , Lin Haifeng , Guo Hong , Ma Yuling , Zhang Jun , Li Qin 
Published: November 2019

Objective
To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer.

Methods
A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed.

Results
Tumor size >2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P < 0.001) and HER-2+ (P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively).

Conclusions
The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.