bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate-Specific Membrane Antigen Expression in Primary Juvenile Nasal Angiofibroma—A Pilot Study
Authors: Sakthivel Pirabu , Thakar Alok , Prashanth Arun , Bhalla Ashu Seith , Kakkar Aanchal , Sikka Kapil , Singh Chirom Amit , Kumar Rajeev , Sharma Suresh Chandra , Kumar Rakesh 
Published: January 2020

Purpose
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and is exploited for imaging and treatment of patients with prostate cancer. Prostate-specific membrane antigen expression is also demonstrated in the tumor-associated neovasculature endothelium. Juvenile nasal angiofibroma (JNA), being a similar highly vascular tumor, may also demonstrate significant PSMA expression, which may be utilized for its imaging and treatment.

Methods
In this prospective study, 25 clinicoradiologically diagnosed primary JNA patients underwent PSMA PET/CT scan. The scan was performed after 45 to 60 minutes of intravenous injection of 2 to 3 mCi (74–111 MBq) of 68Ga-PSMA-HBED-CC on a dedicated PET/CT scanner. Low-dose CT scan was acquired from vertex to sternoclavicular joint (100 mA, 20 kVp, 3-mm slice thickness, 0.8 pitch). Images were reconstructed with iterative reconstruction technique (4 iterations, 24 subsets). The objective was to assess the intensity and pattern of PSMA uptake in primary JNA patients.

Results
All cases (n = 25) of primary JNA showed PSMA expression in the tumor (100%). The median PSMA SUVmax ratio of tumor to background was 4.57 (range, 2.08–7.27). Intracranial extension in 14 of 25 patients was prominently visualized because of absence of background uptake in the brain. Advanced stage tumors demonstrated greater uptake than early tumors (P = 0.011). A statistically nonsignificant trend was noted for decreasing uptake with increasing age after normalizing for stage (Spearman correlation coefficient r = −0.08).

Conclusions
Assessment of PSMA expression in JNA by PSMA PET/CT opens up a new window of opportunity with respect to its radiological staging, vascularity assessment, and molecular characterization. A potential role in identification of the difficult residual-recurrent disease is anticipated and perhaps also in radioligand therapy for residual/recurrent JNA.
Clinical Trials Registry of India (CTRI/2018/08/015479).
18F-FDG PET/CT Imaging Findings of Leprosy
Authors: Shao Dan , Deng Yue-Ting , Shao Fu-Qiang , Liang Jia-Wei , Wang Shu-Xia 
Published: January 2020

Abstract
Leprosy is a chronic infectious disease caused by Mycobacterium leprae infection in susceptible individuals. Without proper clinical diagnosis and treatment, leprosy can have a poor prognosis; however, diagnosing leprosy is challenging. We present a case of leprosy with extensive skin infiltration and involvement of the turbinate mucosa and multiple lymph nodes with increased FDG uptake on PET/CT, mimicking malignancy.
Comparison of Diagnostic Utility of Fluciclovine PET/CT Versus Pelvic Multiparametric MRI for Prostate Cancer in the Pelvis in the Setting of Rising PSA After Initial Treatment
Authors: Chen Bo , Bathala Tharakeswara K. , Xu Guofang , Teyateeti Ajalaya , Chapin Brian F. , Tang Chad , Tu Shi-Ming , Macapinlac Homer A. , Lu Yang 
Published: January 2020

Purpose
The aim of this study was to investigate the imaging diagnostic performance of 18F-fluciclovine PET/CT and pelvic multiparametric MRI (mpMRI) for prostate cancer in the setting of rising PSA after initial treatment, with a focus on detection of recurrent and metastatic prostate cancer in the pelvis.

Methods
Patients with prostate cancer who had fluciclovine PET and pelvic mpMRI between October 2017 and October 2018 in our center were retrospectively reviewed. Patients were included if they had fluciclovine PET/CT and mpMRI within a 3-month interval. Patients were excluded if they had separate concurrent cancer or if the PSA were more than 2-fold difference with an absolute difference more than 1 ng/mL between the 2 image studies. For each eligible patient, we compared all abnormal lesions identified on either scan. The findings were verified by pathology or other imaging techniques within minimal 10-month clinical follow-up.

Results
A total of 129 patients with 129 paired tests were included in this study. Fluciclovine PET/CT and pelvic MRI had a high degree of concordance (121/129, 93.8%). The sensitivity, specificity, positive predictive value, and negative predictive value for fluciclovine PET/CT and mpMRI were 96.6%, 94.3%, 93.4%, and 97%, and 91.5%, 95.7%, 94.7%, and 93%, respectively. There were no statistical significant differences in diagnostic performance between the 2 imaging tests. Among the 8/129 discordant cases, although fluciclovine PET/CT provided definitive diagnosis when mpMRI was equivocal due to paramagnetic artifacts from fiducial markers and detected normal-sized regional lymph nodes, mpMRI detected subcentimeter periurethral recurrence and clarified physiological urinary artifacts that was not appreciated on fluciclovine PET/CT.

Conclusions
Our single-center study demonstrated that fluciclovine PET/CT has similar diagnostic performance with pelvic mpMRI in detecting recurrent/metastatic prostate disease in the pelvis in the setting of rising PSA after initial treatment. Moreover, fluciclovine PET/CT and mpMRI have different implications in different clinical scenario; each test has its own limitation and pitfalls, but can be complementary to each other.
Features of the Ulnar Nerve Predicting Postoperative Prognosis in Idiopathic Cubital Tunnel Syndrome
Authors: Cha Soo Min , Shin Hyun Dae 
Published: January 2020

Purpose
This retrospective case-control study was performed to determine the relationships between features of the ulnar nerve and postoperative outcomes following in situ decompression in idiopathic cubital tunnel syndrome (CuTS).

Methods
The study population consisted of 86 patients who had undergone surgery for CuTS. We evaluated demographic factors, hand dominance, symptom onset time, time from diagnosis to surgery, findings of electrodiagnosis (nerve conduction velocity/electromyography), and preoperative clinical status. Intraoperatively, the ulnar nerve was defined as a definitively compressed, abnormally enlarged, or inflammatory lesion. Clinical improvements were evaluated at least 2 years after surgery.

Results
Fifty-four patients showed improvement after surgery in terms of the modified McGowan grade and were designated as group 1. Meanwhile, 32 patients with unchanged or aggravated status were classified as group 2. Preoperative status, as determined by the modified McGowan grade, Boston Symptom Severity Scale score, severity of electrodiagnosis, and predominant symptoms were similar between the groups (all, P > 0.05). On regression analysis, only the classification of nerve lesions and the time from diagnosis to surgery had an impact on postoperative outcome (all, P < 0.05). Especially, enlarged ulnar lesion predicted poor prognosis (P = 0.003).

Conclusions
Ulnar nerve enlargement, grossly detected intraoperatively, and long interval between diagnosis and surgery were independently associated with poor prognosis of CuTS. Among the anatomic structures involved in the generation of CuTS, the medial epicondyle showed a strong association with enlarged nerve lesions.
The Role of Practice Diversification in the Growth of a Burn Center Network
Authors: Lineaweaver William C. , Bennett Susan , Hills Jocelyn , Mullins Fred 
Published: January 2020

Abstract
Practices within the Burn and Reconstructive Centers of America network have been organized to provide immediate and secondary reconstructive plastic surgery to burn patients. These reconstructive surgery abilities have been further engaged to expand these practices with non–burn-related surgical cases.
Seven Burn and Reconstructive Centers of America practices were analyzed to quantitate the effects of nonburn reconstructive cases on practice growth over a 4-year period (2015–2018).
All surgical cases were performed during the study period and were analyzed to identify burn-related procedures and procedures not related to burn injuries. Fifty-two percent of the cases were burn-related, whereas 48% were not burn-related. Over the 4-year period, burn cases increased by 46%, whereas nonburn cases increased by 84%. The overall percentage of nonburn cases increased from 43% in 2015 to 50% and 49% in 2017 and 2018.
Nonburn cases contributed effectively to practice growth over this period. This practice model successfully engages broad reconstructive surgery skill sets to expand practice volumes.
Evaluation of Microneedling Therapy in Management of Facial Scars
Authors: Vijaya Lakshmi Yenugandula , Swetha Reddy Lingaladinne , Naga Neelima Devi Kolli , Phani Kumar Kuchimanchi , Guru Karthik Gandikota , Srinivas Chakravarthy Pandi , Nageswar Rao Kondrakunta 
Published: January 2020

Background:
Appearance and beauty always have been playing a major aspect of human's lives, regardless of the era. The desire for man to look better had led to various treatment modalities. One among them is microneedling therapy, also called as percutaneous collagen induction therapy or dermaroller therapy. Henceforth, the aim of the study was to evaluate the efficacy of microneedling therapy in the management of facial scars.

Methods:
An observational clinical study was conducted with a total of 14 patients who needed treatment and presented to the out-patient department of Department of Oral and Maxillofacial Surgery. The patients who were cooperative, motivated, and esthetically conscious with facial scars due to trauma, soft-tissue injury following incision and drainage, postsurgical scars, scars following surgery of cleft lip correction, and postacne scars were randomly selected.

Results:
In the present study, a statistically significant difference was observed with pre- and postsurgical patient satisfaction scale (PSS) and observed satisfaction scale (OSS; P = 0.001). Preoperatively there were 64.3% with depressed scars and 35.7% with elevated scars. The clinical response of height of scar postoperatively was 100% flattening with the surrounding skin surface. Results showed that all atrophic and hypertrophic scars showed improvement, and color of the scar which was darker or lighter than the surrounding skin got the same color as the surrounding skin after microneedling therapy. Pain during the procedure was easily tolerable by the patient and no postoperative pain was noted.

Conclusion:
Microneedling therapy can be considered as an effective modality of treatment for facial scars in patients with an added advantage of minimal downtime and effective improvement. It is simple and cost-effective technique in the treatment of facial scars.
Reconstruction of Mandibular Defects With Bone Marrow-Derived Stem Cells in Odontogenic Myxoma
Authors: Shin Hyeon Seo , Kim Min Su , Kim Byung Hoon , Lim Hun Jun , Kim Bong Chul , Lee Jun 
Published: January 2020

Abstract
Odontogenic myxoma is a benign tumor, mostly located in the mandible. It shows locally aggressive behavior and requires surgical removal. Common treatment options for reconstructing the bone defects are immediate or delayed autologous bone graft or free flap. In this article, the authors present the successful reconstruction with autogenous bone graft and autologous human bone marrow mesenchymal stem, followed by distraction osteogenesis, dental implant placement and prosthodontic restoration in the mandibular defect.
Orthognathic Surgical Treatment in a Patient With Hyperimmunoglobulin E Syndrome
Authors: Dibbs Rami , Raghuram Anjali , Roy Michelle G. , Kaufman Matthew G. , Monson Laura A. 
Published: January 2020

Abstract
Autosomal-dominant hyperimmunoglobulin E syndrome (HIES), or Job syndrome, is a rare, multisystem, primary immunodeficiency disorder. Additionally, patients may also suffer from connective tissue, dental, and bone malformations. While current management of HIES is directed at prophylactic antibiotics to prevent infections, there is limited work describing surgical considerations for these patients, particularly with respect to hardware placement. Here we report a case of a patient with HIES who underwent orthognathic surgery for maxillary advancement and mandibular setback to address his severe class III malocclusion. The patient's postoperative course was complicated by significant infection, requiring multiple operations and ultimately, hardware removal after bone healing. Although this patient ultimately had a good outcome, the role of orthognathic surgery with implant placement in patients with HIES should be approached with caution and careful consideration.
Spontaneous and Dramatic Improvements in Open Bite Deformity Secondary to Large Maxillofacial Venous Malformation With Macroglossia After Sclerotherapy and Laser Therapy
Authors: Sun Yi , Gu Hao , Yang Xi , Hu Li , Cai Ren , Chen Hui , Lin Xiaoxi 
Published: January 2020

Background:
Large maxillofacial venous malformation (VM) lesions can affect the craniofacial skeleton, causing occlusal and craniofacial deformity. Few studies have discussed the management of these skeletal disorders. It is unclear whether orthodontic treatment and orthognathic surgery are necessary after such a VM lesion has been significantly reduced.

Methods:
A 13-year-old boy with a large, extensive maxillofacial VM lesion, severe facial asymmetry, macroglossia, and lower lip hypertrophy visited our department in 2010. He received more than 100 sclerotherapy treatments and 20 laser treatments in the past 8 years.

Results:
The patient's cosmetic disfigurement greatly improved, and the VM lesion diminished by more than 80%. Changes in the bite and craniofacial skeleton progressed from “normal” to “open bite with skeletal deformity” and finally to “spontaneously close to normal”.

Conclusions:
During the progression of VM, removal of pathogenic factors can inhibit the aggravation of open bite deformity and promote the spontaneous improvement, thereby circumventing the need for complicated osteotomy, orthodontic intervention and/or orthognathic surgery.
Comparison of Facial Proportions Between Eastern and Western Attractive Young Women
Authors: Yi Chang Ryul , Kim Min Ji , Kim Sung-Chan , Gaxiola-García Miguel , Jeong Woo Shik , Koh Kyung S. , Huh Chang Hun , Kim Hee Jin , Lee Woo Sun , Choi Jong Woo 
Published: January 2020

Abstract
The characteristics of what is considered a beautiful face differ between Eastern and Western countries.
The authors of this study analyzed beauty pageant contestants using a three-dimensional (3D) photogrammetric analysis tool. All of the 3D photographs were taken between October and November 2016 in Seoul, Korea. The participants were 43 Miss Korea contestants (Group I) and 22 Miss Paraguay contestants (Group II).
In absolute length, those in Group I had longer upper and middle faces. In the proportions of volume and length, Group I had larger upper and middle faces than Group II. Widths of the lower face and entire face were also wider in Group I. The lower facial index was larger in Group I. Group I had longer noses and wider intercanthal distance, not only in absolute length but also in proportion to the face. Group II showed thicker lips, longer chins, and wider noses relative to the face. Group II had wide eyes, in the absolute measurement and in proportion to the face. Group I participants appeared to have an increased height of eyes and had wider angles in their faces as well as wider nasofrontal, labiomental, and nasomental angles.
The authors objectively established reference data for faces that are considered attractive in the East and the West. The data are expected to contribute to the clinical practice of plastic surgeons.
Three-Dimensional Measurement of Maxillary Involvement in Hemifacial Microsomia in Children
Authors: Xu Xi , Zhang Zhi-yong , Li Bing-hang , Tang Xiao-jun , Yin Lin , Liu Wei 
Published: January 2020

AbstractIn hemifacial microsomia (HFM), the aberrant mandible structure has always been the focus of attention. How the maxillary development being affected is not clear. The authors sought to comprehensively evaluate the hemifacial maxillary deficiency and to assess for Pruzansky-Kaban score correlation.This is a retrospective research of children with HFM. Demographic information were recorded, and computed tomographic scan were reconstructed and analyzed by segmentation, volumetric and cephalometric measurements. Analyses involved pairedt-test, independent samplet-test and one-way analyses of variance.Demographic information revealed 67 patients diagnosed with HFM were included: 10.4 percent type I, 38.8 percent IIa, 28.4 percent type IIb, 22.4 percent type III. The maxillary total volume was found to be significantly decreased on the affected side in patients with type IIa (P = 0.0426) and IIb (P = 0.0004). No notable differences in maxillary sinus volume were found. No significant differences in maxillary width measurements were found between groups type I and III. A descending trend in maxillary bone volume ratio, an increasing trend in maxillary posterior width ratio and a decreasing trend in maxillary middle height ratio was observed from group I to IIb (pmbv∗ = 0.020;pmpw∗ = 0.002;pmmh∗ = 0.004).This study comprehensively characterized the hemifacial microsomia maxillary deficiency. For maxillary total volume and transverse development, the type III group presented characteristics similar to the type I group. We concluded that the severity of maxillary deficiency is not completely consistent with the mandibular deformity classification.
A Survey of Aesthetic Standards of the Ear
Authors: Lei Liu , Shichun Zhao , Zhenzhong Liu , Qiangwei Wu , Fangfang Huang , Zhensheng Hu , Bo Pan 
Published: January 2020

Background:
The aesthetic standards of the ear are very important for evaluation of auricular surgery. Few studies have previously assessed ear aesthetics, especially in China. This study aimed to investigate aesthetic standards of the ear in a Chinese population.

Materials and Methods:
A questionnaire was administered to Chinese individuals, which included assessment of the general impressions of the ear and other facial aesthetic units, the individual aesthetic subunits of the ear, the effects of different ear subunits on ear symmetry and the degree of the subunits to which the participants wanted to change. Answers were recorded on a five-point Likert-style scale. Statistical analysis was performed using SPSS ver. 17.0.

Results:
A total of 319 responses were received, 50.3% women and 49.7% men. The external ear received the lowest degree of attention either on the front or on the lateral view of the face in both genders. Among the individual aesthetic units, the earlobe received the most attention and the fine structures the lowest. The helix had the greatest effect on the ear symmetry. The structure that participants most wanted to change was the earlobe in males and the helix in females. There were significant differences on the evaluation of the helix and crus of helix among the groups divided according to educational background (P < 0.001).

Conclusion:
The results showed that the structures that people were most concerned about were the helix and earlobe. There were gender differences in the results which were also influenced by education background.
Negative Pressure Wound Therapy With Chymotrypsin Irrigation: A Maximal Implant Retention Procedure Treating the Exposure/Infection of Titanium Mesh in Cranioplasty
Authors: Huang Zugen , Lei Chen , Zhang Ling , Xue Huadong , Shen Jian , Wu Shanying , Wang Biao , Chen Jianwu 
Published: January 2020

Abstract
This preliminary study aims to investigate the effects of a maximal implant retention procedure. The authors retrospectively reviewed the use of negative pressure wound therapy with chymotrypsin irrigation treating implant infection/exposure in titanium mesh cranioplasty by comparing patients with titanium mesh totally retained, partially removed, or totally removed according to the evaluation during the surgery. Negative pressure wound therapy with chymotrypsin irrigation was applied 5 days after the surgery. The negative pressure was set at −125 to −150 mmHg. A total of 21 patients were included, 4 patients treated with titanium mesh totally removed; 3 patients treated with titanium mesh partially removed; and 14 patients treated with U-shape debridement with titanium mesh preserved completely. However, 1 patient in the U-shape group required a second debridement to remove all implant. Negative pressure wound therapy with chymotrypsin irrigation is a novel procedure and could be used to treat implant-related infection without the exchange of implant.
The Preliminary Application of Augmented Reality in Unilateral Orbitozygomatic Maxillary Complex Fractures Treatment
Authors: Chen Gang , Zeng Wei , Yin Huaqiang , Yu Yunbo , Ju Rui , Tang Wei 
Published: January 2020

Purpose:
Try to apply augmented reality (AR) technique which based on visual recognition artificial marks in the treatment of unilateral Orbitozygomatic Maxillary complex fractures (OZMF), and to explore the feasibility and the application value of the AR for assisting the oral and maxillofacial surgery (OMFS) treatment.

Methods:
Based on the AR application JSARToolKit developed on the web, and combining with the self-designed tooth-borne type visual recognition artificial marks to display three-dimensional (3D) image of the region of interest (ROI), virtually designed the position and direction of plate on the jaw and helped OZMF surgery. According to some results to evaluate the postoperative effects, such as imaging, occlusion, facial appearance recovery, patients’ satisfaction and operation time.

Results:
The AR achieved the 3D image of ROI in real time, satisfied information enhancement of real scene, broadened the surgeon's horizons and improved the 3D recognition ability of maxillofacial tissue. After operation, patients had no discomforts, fracture reduction were well healed through imaging examination, and the titanium plate position was consistent with the preoperative planning. What is more, patients’ facial appearance and occlusal function recovered well, significantly shorten the intraoperation time.

Conclusion:
Augmented reality technology is an effective method for OZMF treatment but there are still many technical difficulties which need to be get over, and its application in maxillofacial surgery and relevant basic theories are both worth further exploring.
Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis
Authors: Nolan Lila S. , Wynn James L. , Good Misty 
Published: January 2020

ABSTRACT
Neonatal shock and necrotizing enterocolitis (NEC) are leading causes of morbidity and mortality in premature infants. NEC is a life-threatening gastrointestinal illness, the precise etiology of which is not well understood, but is characterized by an immaturity of the intestinal barrier, altered function of the adaptive immune system, and intestinal dysbiosis. The complexities of NEC and shock in the neonatal population necessitate relevant clinical modeling using newborn animals that mimic the disease in human neonates to better elucidate the pathogenesis and provide an opportunity for the discovery of potential therapeutics. A wide variety of animal species—including rats, mice, piglets, and primates—have been used in developing experimental models of neonatal diseases such as NEC and shock. This review aims to highlight the immunologic differences in neonates compared with adults and provide an assessment of the advantages and drawbacks of established animal models of both NEC and shock using enteral or intraperitoneal induction of bacterial pathogens. The selection of a model has benefits unique to each type of animal species and provides individual opportunities for the development of targeted therapies. This review discusses the clinical and physiologic relevance of animal models and the insight they contribute to the complexities of the specific neonatal diseases: NEC and shock.