bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appropriate reduction of the fragmentation level of subfield sequences to improve the accuracy of field delivery in IMRT for nasopharyngeal carcinoma
Authors: Sun Yanze , Zhou Gang , Zhu Yaqun , Zou Li , Tian Ye 
Published: February 2020

Objective:
Due to the influence of gravity, inertia and friction, there will be deviation between the position of multileaf collimator (MLC) in the delivered field and the initial intensity modulated radiotherapy (IMRT) plan. This study explores the effects of the fragmentation level of subfield sequences on this deviation and seeks ways to improve the accuracy of field delivery in IMRT for nasopharyngeal carcinoma (NPC).

Methods:
30 patients with NPC were selected, and two groups (groups A and B) of IMRT plans were made in Pinnacle planning system. Different planning parameters were used for optimization so that the subfield sequence fragmentation level of Group B was significantly lower than that of Group A. With the MapCheck2, verification plan was implemented in two ways: 0o gantry angle and the actual treatment angle, then the differences between the two verification results of each group plan were analyzed.

Results:
The γ-passing rate verified at the actual treatment angle was lower than that of 0o gantry angle for each group plan, whereas the Group B plan shows small reduction. Mean change value (Δ) was decreased from 1.01% (Group A) to 0.40% (Group B) with 3%/3 mm criteria and 2.88% (Group A) to 1.52% (Group B) with 2%/2 mm criteria, respectively. The smaller the difference (Δ), the actual output dose of the field is more consistent with the original plan. There was no significant correlation between this change and the angle of the field.

Conclusion:
Appropriately reducing the fragmentation level of subfield sequence can reduce the effect of field angle on MLC position and improve the delivery accuracy of IMRT plan.

Advances in knowledge:
The fragmentation level of the subfield sequence may have an impact on the accuracy of the delivery of the plan. This study demonstrates this assumption by comparing the differences between 0° and actual angle verification. Mean change value (Δ) was decreased from Group A to Group B. The smaller the difference (Δ), the actual output dose of the field is more consistent with the original plan. The result of this study may help us to understand that appropriately increasing the subfield area and reducing the fragmentation level of the subfield sequence can reduce the difference between the two verification results, which can further improve the accuracy of the plan delivery in IMRT and tumor treatment.
Toward a paradigm shift from deficit-based to proactive speech and language treatment: Randomized pilot trial of the Babble Boot Camp in infants with classic galactosemia
Authors: Peter Beate , Potter Nancy , Davis Jennifer , Donenfeld-Peled Inbal , Finestack Lizbeth , Stoel-Gammon Carol , Lien Kari , Bruce Laurel , Vose Caitlin , Eng Linda , Yokoyama Hanako , Olds Daniel , VanDam Mark 
Published: February 2020

Background: Speech and language therapy is typically initiated reactively after a child starts showing delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth. We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC). Method: Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing. Results: All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG. Discussion: Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization. Trial registration: ClinicalTrials.gov NCT03838016 (12 th February 2019).
Small for gestational age babies and depressive symptoms of mothers during pregnancy: Results from a birth cohort in India
Authors: Babu Giridhara R. , Murthy G.V.S. , Reddy Yogesh , Deepa R. , Yamuna A. , Prafulla S. , Krishnan Anjaly , Lobo Eunice , Rathnaiah Mohanbabu , Kinra Sanjay 
Published: February 2020

Background: Annually, more than a million low birthweight (LBW) is born in India, often afflicting disadvantaged families. Several studies have undertaken the association of poverty, nutritional status, and obstetric factors with LBW. Through our study, we aimed to examine the possibility of any relation between the Edinburgh Postnatal Depression Scale (EPDS) score measured during pregnancy with the incidence of babies born Small for Gestational Age (SGA). Methods: Pregnant women attending the antenatal clinic at a public hospital between 14 to 32 weeks were recruited from April 2016 to Oct 2017. The EPDS was administered to assess depression through face-to-face interviews. Newborn anthropometry was performed post-delivery. For analysis, birth weight <10 percentile was classified as SGA. Results: Prevalence of depressive symptoms (EPDS score >11) was 16.5% (n=108/654) in antenatal mothers. These women delivered a higher proportion of SGA babies (21.3 v/s 15.8) compared to women with no symptoms. The odds of women giving birth to a child with SGA were twice as high for women with EPDS scores >11 (adjusted OR = 2.03; 95% CI = 1.12 – 3.70) compared to the women with EPDS scores of ≤11, The EPDS 12 (Adjusted OR = 1.96; 95% CI = 1.04 – 3.69) and EPDS 13 (Adjusted OR = 2.42; 95% CI = 1.24 – 4.70) cut-off categories also proved to be a risk factor for SGA with significant p-value (0.0006 and 0.0003) and the individuals with more than 13 EPDS score is found to have the highest odds of SGA. Conclusions: We found a strong association of antenatal depressive symptoms during pregnancy with SGA measured by EPDS. Thus, we recommend the implementation of timely and effective screening, diagnostic services, and evidence-based antenatal mental health services to combat SGA and further associated-metabolic syndromes.
Exploring the role of RRM domains and conserved aromatic residues in RGG motif of eIF4G-binding translation repressor protein Sbp1
Authors: Bhatter Nupur , Iyyappan Rajan , Rajyaguru Purusharth I 
Published: February 2020

Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in affecting mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In this report we have assessed the genetic interaction of Sbp1 with decapping activators such as Dhh1, Pat1 and Scd6. We have further analyzed the importance of different domains and specific conserved residues of Sbp1 in translation repression activity. Method: Sequence alignment was performed to identify conserved aromatic residues to be mutated. Using site-directed mutagenesis several point mutations and domain deletions was created in Sbp1 expressed under a galactose-inducible promoter. The mutants were tested for their ability to cause growth defect upon over-expression. The ability of Sbp1 to affect over expression mediated growth defect of other decapping activators was tested using growth assay. Live cell imaging was done to study localization of Sbp1 and its RRM-deletion mutants to RNA granules upon glucose starvation. Results: Mutation of several aromatic residues in the RGG-motif and that of the phosphorylation sites in the RRM domain of Sbp1 did not affect the growth defect phenotype. Deletion of another eIF4G1-binding RGG-motif protein Scd6 does not affect the ability of Sbp1 to cause growth defect. Moreover, absence of Sbp1 did not affect the growth defect phenotypes observed upon overexpression of decapping activators Dhh1 and Pat1. Strikingly deletion of both the RRM domains (RRM1 and RRM2) and not the RNP motifs within them compromised the growth defect phenotype. Sbp1 mutant lacking both RRM1 and RRM2 was highly defective in localizing to RNA granules. Conclusion: This study identifies an important role of RRM domains independent of RNP motif in Sbp1 repression activity.
Predicting epiphyseal stability of slipped capital femoral epiphysis with preoperative CT imaging
Authors: Fischer-Colbrie Megan E. , Louer Craig R. , Bomar James D. , Hahn Peter , Edmonds Eric W. , Pennock Andrew T. , Upasani Vidyadhar V. 
Published: February 2020

Background We analyzed preoperative CT scans of hips with slipped capital femoral epiphysis (SCFE) for characteristics that could be predictive of intraoperative epiphyseal stability and developed a set of imaging criteria for stable and unstable SCFE. We then compared this grading system with the Loder classification. Methods We reviewed preoperative CT imaging to develop a SCFE stability classification system. Three orthopaedic surgeons used the classification system to grade stability on a series of SCFE hips. Kappa was used to evaluate intra- and interobserver reliability among the observers. A series of SCFE hips treated with open procedures in which intraoperative stability was determined under direct visualization was evaluated. Intraoperative stability was compared with stability ratings as determined by the CT classification system and the Loder classification system. Results Interobserver reliability among our three observers was κ = 0.823 (95% confidence interval (CI) 0.414 to 1.0; p < 0.001). Intraobserver reliability was κ = 0.901 (95% CI 0.492 to 1.31; p < 0.001). In all, 27 hips were used in the comparison of intraoperative stability with the Loder and CT classification systems. CT-predicted stability exhibited 78% concordance with intraoperative stability. The sensitivity and specificity of CT-predicted stability was 75% and 82%, respectively, versus Loder sensitivity of 69% and specificity of 91%. Conclusion The CT evaluation method provided is easy to use and can help to improve the accuracy in determining preoperative epiphyseal stability, which may lead to improved treatment outcomes for this population. Level of Evidence III
Measurement method of optical properties of ex vivo biological tissues of rats in the near-infrared range
Authors: Sanchez-Cano Ana , Saldaña-Díaz José Eduardo , Perdices Lorena , Pinilla Isabel , Salgado-Remacha Francisco Javier , Jarabo Sebastián 
Published: February 2020

An optical fiber-based supercontinuum setup and a custom-made spectrophotometer that can measure spectra from 1100 to 2300 nm, are used to describe attenuation properties from different ex vivo rat tissues. Our method is able to differentiate between scattering and absorption coefficients in biological tissues. Theoretical assumptions combined with experimental measurements demonstrate that, in this infrared range, tissue attenuation and absorption can be accurately measured, and scattering can be described as the difference between both magnitudes. Attenuation, absorption, and scattering spectral coefficients of heart, brain, spleen, retina, and kidney are given by applying these theoretical and experimental methods. Light through these tissues is affected by high scattering, resulting in multiple absorption events, and longer wavelengths should be used to obtain lower attenuation values. It can be observed that the absorption coefficient has a similar behavior in the samples under study, with two main zones of absorption due to the water absorption bands at 1450 and 1950 nm, and with different absolute absorption values depending on the constituents of each tissue. The scattering coefficient can be determined, showing slight differences between retina and brain samples, and among heart, spleen and kidney tissues.
High-harmonic generation wave front dependence on a driving infrared wave front
Authors: Wodzinski Thomas , Künzel Swen , Koliyadu Jayanath C. P. , Hussain Mukhtar , Keitel Barbara , Williams Gareth O. , Zeitoun Philippe , Plönjes Elke , Fajardo Marta 
Published: February 2020

With high-harmonic generation (HHG), spatially and temporally coherent XUV to soft x-ray (100 nm to 10 nm) table-top sources can be realized by focusing a driving infrared (IR) laser on a gas target. For applications such as coherent diffraction imaging, holography, plasma diagnostics, or pump–probe experiments, it is desirable to have control over the wave front (WF) of the HHs to maximize the number of XUV photons on target or to tailor the WF. Here, we demonstrate control of the XUV WF by tailoring the driving IR WF with a deformable mirror. The WFs of both IR and XUV beams are monitored with WF sensors. We present a systematic study of the dependence of the aberrations of the HHs on the aberrations of the driving IR laser and explain the observations with propagation simulations. We show that we can control the astigmatism of the HHs by changing the astigmatism of the driving IR laser without compromising the HH generation efficiency with a WF quality from

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. This allows us to shape the XUV beam without changing any XUV optical element.
Absolute frequency and hyperfine structure of 127I2 transitions at 531.5  nm by precision spectroscopy using a narrow-linewidth diode laser
Authors: Sakagami Haruki , Yoshii Kazumichi , Kobayashi Takumi , Hong Feng-Lei 
Published: February 2020

The absolute frequency and hyperfine structure of the

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transitions of molecular iodine at 531.5 nm are measured using high-resolution spectroscopy based on a narrow-linewidth planar-waveguide external cavity diode laser. The absolute frequencies of the transitions are determined with an uncertainty of 5.7 kHz, while the hyperfine structures are measured with an uncertainty of

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. High-precision hyperfine constants are obtained by fitting the measured hyperfine splittings, with an uncertainty of approximately 1 kHz, to a four-term Hamiltonian that includes the electric quadrupole, spin–rotation, tensor spin–spin, and scalar spin–spin interactions. The measured absolute frequencies and hyperfine structures are useful for optical frequency metrology and studies of molecular iodine.
Editorial: Working-class heritage and the city
Authors: Millington Gareth , Wallace Andrew 
Published: February 2020

Abstract
Here, we introduce a series of concepts and debates that provide a meta-context for the papers on the topic of working-class heritage and the city that follow. We propose Henri Lefebvre's seminal work on the dissolution of the city as a theoretical framing device via brief detours through notions of museification, authenticity and 'communicity'. The fundamental problematic, as we see it, is that urban working-class heritage is symptomatic of the dissolution of the industrial city and an attempt – conditioned by economic, social, cultural and political imperatives – to reimagine and/or reconfigure the legacies of this city. While we agree that heritage is an active process – it is selected, curated, narrated and interpreted, or 'decoded' by individuals and social groups in a reflexive manner – we also suggest, on the evidence of the papers collected here, that working-class heritage delivers an ambivalent experience and response.
Between 'creative' boost and political dysfunction: An exploration of class, culture and economic dislocation in East Berlin
Authors: Blokland Talja , Juhnke Sebastian 
Published: February 2020

Abstract
In cities where tourism, creative industries and new service economies are boosting, the continuing impact of de-industrialization is less prominent than in discussions of, for example, former Rustbelt cities. Yet, these cities display new forms of intra-urban inequalities that are, beyond the discussion of gentrification, not strongly visible in urban sociology discourses. While scholarly work on Berlin focuses on its gentrification and touristification, urban social movements and forms of migration, less attention is paid to the city as a site of de-industrialization, economic dislocation, class-based defamations and the resulting labelling of political dysfunctionality of certain parts of the population. Exploring the less visible yet ongoing effects of de-industrialization in the post-socialist context of a formerly divided city, this article contributes to a better conceptual understanding of the economic dislocation of the (previous) working classes of East Berlin. It is argued that effects of deindustrialization are related to the cultural and relational production of class through the organization of socialist industrial work and that these effects are ongoing, yet silenced. Lastly, the article outlines a set of hypotheses regarding the friction of a decreasing public, yet continued personal relevance of industrial and working-class heritage, socially and materially, in the city.
Sign language interpreting in the Pacific: A snapshot of progress in raising the participation of deaf people
Authors: McKee Rachel , Iseli Jacqueline , Murray Angela 
Published: February 2020

Abstract
Barriers to acquiring and using a shared sign language alienate deaf children and adults from their fundamental human rights to communication, education, social and economic participation, and access to services. International data collected by the World Federation of the Deaf (WFD) identify that in economically developing countries, deaf individuals are at particularly high risk of marginalization, which applies to countries in the Pacific region. This report provides a snapshot of the status of deaf people as sign language users in six Pacific nations: Fiji, Papua New Guinea (PNG), Samoa, Solomon Islands, Timor Leste and Kiribati. Information was contributed by sign language interpreters from these countries during a panel convened at the first Oceania regional conference of the World Association of Sign Language Interpreters, in Fiji, 2018. The report outlines conditions for education through sign language and the emergence of sign language interpreting as a means of increasing access and social equity for deaf people in these countries, albeit this remains largely on a voluntary basis. While Fiji and PNG governments have recognized the status of sign languages in their respective countries and allocated some resources to the inclusion of sign language users, practical support of deaf sign language users tends to be progressed on grounds of disability rights rather than language rights; e.g., several Pacific countries have ratified the United Nations Convention on the Rights for People with Disabilities, which includes provisions for sign language users, and deaf advocacy efforts have gained political traction from alliance with disability organizations.
Penyakit Mosaik Kuning Pada Kedelai
Authors: Sutrawati Mimi , Hidayat Sri Hendrastuti , Wahyu Soekarno Bonny Purnomo , Nurmansyah Ali 
Published: February 2020

Ledakan penyakit mosaik kuning yang disebabkan oleh Mungbean yellow mosaic India Begomovirus (MYMIV) terjadi pada tanaman kacang panjang (Vigna unguiculata subsp. sesquipedalis) di Jawa pada 2008. Namun penyakit ini belum dilaporkan di daerah lainnya di Indonesia. Tanaman kedelai di Cirebon, Jawa Barat, Bantul, DI Yogyakarta, dan Musi Banyuasin Sumatera Selatan menunjukkan gejala sistemik berupa mosaik kuning pada daun dengan tulang daun lebih gelap (vein banding) dan diduga terinfeksi MYMIV. Deteksi dan identifikasi virus dilakukan dengan metode polimerase chain reaction (PCR) dengan menggunakan primer spesifik MYMIV. Hasil amplifikasi menghasilkan pita DNA berukuran 1000 pb. Hasil ini menunjukkan bahwa tanaman kedelai yang bergejala mosaik kuning dari Cirebon, Bantul, Musi Banyuasin, dan positif terinfeksi MYMIV. Hasil analisis homologi sikuen nukleotida tanaman kedelai yang terinfeksi MYMIV asal Cirebon mempunyai homologi yang tinggi (98.6-99.2 %) dengan MYMIV dari Tegal, Subang, Klaten, Magelang, Brebes, dan Bogor yang menginfeksi tanaman kacang panjang. Analisis filogenetik menunjukkan bahwa isolat MYMIV Cirebon berada satu kelompok dengan semua sikuen MYMIV di Indonesia dan Oman, namun terpisah dengan kelompok MYMIV dari Bangladesh, Nepal, Pakistan dan India. Sikuen isolat MYMIV Cirebon telah didaftarkan ke GenBank dengan nomor aksesi LC481009. Sebelumnya MYMIV dilaporkan pada kedelai di Jawa tahun 2013. Temuan ini merupakan laporan pertama infeksi MYMIV pada kedelai di luar Jawa (Musi Banyuasin, Sumatera Selatan).
Activity Level and Intensity of Older Adults in Skilled Nursing Rehabilitation Measured via Actigraphy
Authors: Bland Marghuretta D. , Barco Peggy , Lang Catherine E. , Lenard Emily , Kallmi Selmi , Pennock Sarah , Lenze Eric J. 
Published: February 2020

Background and Purpose:
Increasing activity has been shown to improve outcomes in patients receiving post–acute rehabilitation, but little is known about the activity duration and intensity that are actually occurring throughout the rehabilitative stay for older adults in skilled nursing facilities. The purpose of this study was to quantify duration and intensity of movement in older adults receiving rehabilitation in a skilled nursing facility, using 4-limb actigraphy.

Methods:
Observational study of 92 older adults admitted for rehabilitation services at 2 skilled nursing facilities. All participants wore actigraph accelerometers (wGT3X+) on bilateral wrists and ankles for 24 hours, inclusive of 1 session each of physical and occupational therapy. Using actigraphy data, we calculated (a) movement duration (time the dominant or noninvolved upper or lower limb was active) and (b) movement intensity (sum of activity counts per minute for the dominant or noninvolved upper or lower limb).

Results:
Over the 24-hour period, the lower limb moved a total median [interquartile range] of 01:10 (hours:minutes) [01:01] and the upper limb moved a total average (SD) of 04:45 (02:00). When participants did move, it was at low intensities with 61 [87] and 610 [623] activity counts per minute for lower limb out-of-therapy time and during physical therapy, respectively. For the upper limb, activity counts per minute were 689 (388) for out-of-therapy movement and 1359 (695) during physical therapy. However, neither the lower or upper limb reached a moderate-intensity level (2690-6166 counts per minute).

Discussion:
Older adults receiving rehabilitation in 2 skilled nursing facilities had low movement duration and movement intensity both in and out of therapy.

Conclusion:
Rehabilitation interventions for older adults should target and increase movement duration and intensity, during and after skilled nursing facility care.