bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice
Authors: Rehman Ahad Abdul , Riaz Azra , Asghar Muhammad Arif , Sikandar Bushra , Baig Moona 
Published: November 2020

Background: Anxiety and depression are very common in clinical practice and reduce the overall quality of life. In recent years, various researchers have focused on natural products which are derived from medicinal plants. Studies suggested that diet rich in flavonoids, vitamins and antioxidants are the important components in reduction of anxiety and depression.
Objective: Hence current investigation was aimed to assess the anxiolytic and antidepressant effects of Syzygium cumini in mice at 125, 250 and 500 mg/kg.
Methods: These effects were mainly evaluated twice at 8th and 15th days by elevated plus maze, open field test, forced swimming test and tail suspension test.
Results and Conclusion: In open field test S. cumini showed escalation rearing in numbers and its duration which indicates improved exploratory behavior and locomotor activity of the animals. In EPM, there was increase in entries numbers and time spent in open arm. Decrease in immobility duration observed at low dose while high dose increased immobility duration in FST. Hence outcomes of current study indicate that S. cumini have anxiolytic and anti-depressant effect.
What is New in COVID-19 and What We Need to Do Against This Pandemic Infection? A Comparative Review
Authors: Naeem Sadaf , Shafiq Yousra , Asghar Muhammad Arif 
Published: November 2020

Background: Initially, large number of COVID-19 cases reported from Wuhan City, China, reflected that this is likely the zoonotic origin of COVID-19. In March, 2020; it has since been declared a serious pandemic infection by the World Health Organization (WHO).
Objective: The main objective of this review was to addressed what gaps still exist. Many researchers have reported the many common characteristics of COVID-19 virus in comparison with other pandemic viruses, while the major differences are discussed in this review.
Method: In this review, we investigated the general characteristics of COVID-19 its diagnosis and other preventive measures in comparison with other pandemic viruses that we know or we need to know.
Results: All reported corona viruses belong to the one genus and family Coronavirus and Coronaviridae. The COVID-19 virus spreads easily and exponentially multiple times compares to other viruses. It can be divided into four antigenic groups, HKU1, NL63, 229E and OC43. The case mortality rate of this pandemic is 1.68%, compared to other pandemics in their first outbreaks, including the great pandemic influenza (0.2%), SARS-CoV (10%), MERS-CoV (34%), and Ebola (50%). Laboratory findings related to COVID-19 include elevated levels of D-dimer, Alanine transaminase (ALT), LDH (lactate dehydrogenase), C-reactive protein (CRP), creatine kinase and prothrombin times.
Conclusion: This comparison based review will help to understand the biology, potential risk and preventive measures of COVID-19 and provide cognizance about what we need to do against this pandemic which victimized more than 200 countries up to the present time.
RİSÂLETÜ’N-NUSHİYYE’DE Kİ / KİM BAĞLAÇLARININ KULLANILIŞI
Authors: ÇAL Ahmet 
Published: November 2020

Türkçe temel yapısı bakımından bağlaçlara pek elverişli bir dil değildir. Yardımcı cümlelerin kuruluşunda kullanılan bağlaçlar, Türklerin ilk karşılaştıkları milletlerin dillerinden alınarak Türkçeye aktarılmıştır. Türkçede eskiden beri var olan kaçan, kayru, kim, ne gibi kelimelere yabancı dillerdeki yardımcı cümleleri bağlamak için yeni anlamlar verilmiştir. Türkçenin çeşitli şartlar altında başka dil ve kültürlerin etkisinde kalması Türkçeye birtakım bağlaçların girmesine de yol açmıştır. Özellikle İslamiyet’in kabulünden sonra Türkçeye, Arapça ve Farsçadan bazı edat ve bağlaçların girdiği görülmektedir. Bu bağlaçlardan biri de Farsçadan dilimize girmiş olan ki bağlacıdır. Özellikle Eski Anadolu Türkçesi döneminde sıkça kullanılan ki bağlacı genellikle pekiştirme, kuvvetlendirme, sebep-sonuç, açıklama vs. fonksiyonlar üstlenerek yardımcı cümle ile temel cümle arasında bağlantı kurmuştur. Eski Türkçeden beri Türkçenin her döneminde kullanılan kim soru zamiri, ki’nin etkisiyle Eski Anadolu Türkçesi döneminde soru zamiri işlevinin yanında bağlaç fonksiyonu da kazanmıştır.
Bu çalışmada XIII. ve XIV. yüzyıl edebiyatının en güzel mesnevi örneklerinden biri olan Risâletü’n-Nushiyye adlı eserdeki ki ve kim bağlaçlarının kullanımı ve işlevleri üzerinde durulacaktır.
Mumbai, Delhi : deux avatars indiens de la démocratie urbaine
Authors: Tawa Lama Stéphanie , Noûs Camille 
Published: November 2020

Dans la démocratie indienne, la ville a longtemps été une catégorie mineure sinon inexistante. Mais si les institutions de la démocratie urbaine restent faibles aujourd’hui, les grandes villes indiennes sont le lieu et l’objet de pratiques politiques qui constituent autant de revendications en actes d’un droit à la ville. Deux mégapoles sont à cet égard particulièrement intéressantes. Mumbai et Delhi sont respectivement le berceau de deux partis politiques exceptionnels dans le paysage national : essentiellement urbains, ils allient une puissance locale de mobilisation, appuyée sur des pratiques originales, avec un discours politique qui résonne au niveau national. L’article s’attachera ainsi à comparer les discours et les pratiques de la Shiv Sena (Armée de Shivaji), parti régionaliste hindou à Mumbai, et ceux de l’Aam Aadmi Party (Parti de l’homme ordinaire), formation néo-gandhienne à Delhi. Nous montrerons comment ces deux partis définissent (de manière plus ou moins explicite), à travers la figure du citadin légitime, deux modèles contrastés de citoyenneté urbaine
Cadres et formes identitaires - Vicariantes et pratiques en orientation
Authors: Guichard Jean 
Published: November 2020

Le vingtième siècle a été marqué par un foisonnement conceptuel relatif à l’individu, au « soi », à « l’identité », etc. Au moins six grands courants de pensée peuvent être distingués. Certains d’entre eux relèvent le rôle des structures sociales ou des interactions ou d’interlocutions dans la formation de la « subjectivité » alors que d’autres se centrent beaucoup plus sur le « sujet » en tant que tel. Le modèle des cadres et des formes identitaires vicariantes se propose d’intégrer ces différentes approches. Il distingue les cadres identitaires (schémas cognitifs relatifs aux catégories de personnes que l’expérience sociale conduit les membres d’une société à concevoir) et les formes identitaires (dans lesquelles ceux-ci perçoivent autrui et se construisent). Ce modèle postule que ces cadres forment un système cognitif. Il pose que les formes identitaires subjectives (dans lesquelles les individus se construisent) sont susceptibles de vicariance : elles dépendent notamment des contextes où l’individu interagit (de ses interactions et interlocutions). La subjectivité (l’identité) est ainsi conçue comme le système unifié et structuré des formes identitaires dans lesquels l’individu se construit et se représente. La stabilité ou la malléabilité du soi dépendent ainsi des degrés (l) de développement de la société et (2) d’intégration des différents domaines du cosmos social ainsi que de la variété des interactions contextualisées dans lesquelles le sujet s’engage. Plusieurs validations indirectes de ces hypothèses sont proposées. Elles permettent de comprendre le rôle que les interlocutions jouent dans la construction de soi, lors d’interactions de conseil. Elles conduisent à s’interroger sur les finalités et les objectifs des pratiques en orientation.
NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor
Authors: Sun Boyue , Zeng Haoyang , Liang Jiaqian , Zhang Lele , Hu Haiyang , Wang Quanyi , Meng Wei , Li Chenhui , Ye Fuqiang , Wang Chen , Zhu Juanjuan 
Published: November 2020

Abstract
The RIG-I receptor induces the innate antiviral responses upon sensing RNA viruses. The mechanisms through which RIG-I optimizes the strength of the downstream signaling remain incompletely understood. In this study, we identified that NSUN5 could potentiate the RIG-I innate signaling pathway. Deficiency of NSUN5 enhanced RNA virus proliferation and inhibited the induction of the downstream antiviral genes. Consistently, NSUN5-deficient mice were more susceptible to RNA virus infection than their wild-type littermates. Mechanistically, NSUN5 bound directly to both viral RNA and RIG-I, synergizing the recognition of dsRNA by RIG-I. Collectively, to our knowledge, this study characterized NSUN5 as a novel RIG-I coreceptor, playing a vital role in restricting RNA virus infection.
Evoluzione storica delle “Carte dei diritti dei morenti”
Authors: Pennacchini M. , Sacchini D. , Spagnolo A.G. 
Published: November 2020

L’intento perseguito dagli autori con questo lavoro è stato quello di ripercorrere l’evoluzione negli ultimi decenni delle “carte” in cui vengono indicati i diritti delle persone morenti. Una storia che si va a contrapporre, con una sorprendente coincidenza nella cronologia, ai successivi momenti della depenalizzazione, prima, e della legalizzazione, poi, dell’eutanasia. Tali “carte”, infatti, hanno sostanzialmente inteso contrapporre il right to death with dignity al right to death senza altre specificazioni, rivendicato dai movimenti e dalle società a favore dell’eutanasia volontaria e del suicidio assistito.
Questo lavoro, quindi, trova il suo momento iniziale con l’identificazione e l’analisi delle motivazioni socio-culturali oltre che di quelle più propriamente scientifiche che hanno portato all’elaborazione della prima carta dei diritti del morente, capostipite in un certo senso di tutte quelle seguenti. Dopo di che mostra l’evoluzione peculiare che tali carte, c.d. di prima generazione hanno avuto in Europa, e da ultimo illustra come esse si sono evolute, sia in Europa sia negli Usa in anni più recenti.
Da ultimo, a conclusione della “review” storica, gli autori hanno voluto presentare la Carta dei diritti del malato cronico in evoluzione di malattia elaborata nel 1999 all’interno del Policlinico Universitario “Agostino Gemelli” dell’Università Cattolica, esaminandone il contenuto e le ragioni che hanno portato alla sua elaborazione.
PGS1, a new low cost and low power Portable Geo-physical Station “All in One”. Design and test
Authors: Costanza Antonio , Fertitta Gioacchino , Yang William , D'Anna Giuseppe , Chiarabba Claudio 
Published: November 2020

PGS1 is a new compact portable seismic station, designed at INGV OBS and Earth Lab, that is specifically intended for the deployment of dense arrays of seismographs on-shore. With its low cost, compact design, high data-quality and long battery life, PGS1 is a perfect solution for seismic monitoring networks. PGS1 design is based on a solid polypropylene suitcase, containing a complete data acquisition system, two battery packs and a photovoltaic panel. The new Earth Lab 5s medium-period seismic sensor is included. The whole system meets the IP67 standard requirements both in transport and in acquisition configuration. PGS1 is normally equipped with one battery pack, one more pack can be added inside the suitcase achieving 40 days of battery life. The station is equipped with a photovoltaic panel, useful to extend the deployment length. Inside the suitcase, there are compartments where to store the seismic sensor, the photovoltaic panel and all the cables. Therefore, the station is very easy to transport.
Adesão ao tratamento com antineoplásicos orais em pacientes com câncer de mama
Authors: Ribeiro Teixeira Alinne , Moreira Ruiz Bianca , Ramalho Cardoso Nathalia , De Franco Rennó Verônica 
Published: November 2020

Objetivos: avaliar fatores associados à adesão ao tratamento com fármacos de ação antineoplásica por via oral em pacientes com câncer de mama. Métodos: foi realizado levantamento bibliográfico do período de 2002 a 2018 nas bases de dados Scielo, Pubmed e Lilacs. Foram selecionados 50, após leitura dos resumos, foram selecionados 30 estudos para leitura completa. Com isso, foram excluídos os que se referem ao acompanhamento farmacoterapêutico de outras doenças não compatíveis com o tema. Dos estudos avaliados, 22 abordavam o tema do estudo e foram utilizados como referência. Conclusão: a adesão ao tratamento com antineoplásicos orais para o tratamento de câncer de mama ainda é um desafio para saúde pública e, em especial para os farmacêuticos que atuam na dispensação dos referidos medicamentos. Com o estudo, foi possível observar que existem múltiplas variáveis que interferem na adesão ao tratamento, sendo que muitos dos fatores envolvidos, estão ligados à elementos intrínsecos da paciente. Entretanto, quando se analisam os fatores extrínsecos, percebe-se que a atuação do farmacêutico no momento da dispensação possui grande influência no sucesso do tratamento, uma vez que é notável que a correta e adequada orientação quanto ao tratamento proposto é um fator fundamental para aumentar a adesão ao tratamento por mulheres com câncer de mama. Com isso, pode-se inferir que se faz necessária a educação continuada de profissionais da saúde que atuam nesta etapa tão importante do tratamento das pacientes.
Estudo comparativo de custo-efetividade de técnicas farmacológicas para prevenção de náuseas e vômitos pós-operatórios em gastroplastias
Authors: Pereira da Silva Bruna , Pellegrini Gustavo Batista , Vasco Pereira Gustavo José 
Published: November 2020

Introdução: As náuseas e vômitos são um dos maiores problemas em pós-operatórios gerando custos não previstos que podem e devem ser evitados. Com a introdução da farmacoeconomia, foi possível prever eventos adversos relacionados a cirurgias e, com isso, mitigar a probabilidade de impactos econômicos negativos relacionados a estes eventos. Objetivo: O objetivo deste estudo é avaliar as mais diversas técnicas farmacológicas de prevenção de náuseas e vômitos pós-operatórios em gastroplastias, baseando-se em estudos de custo-efetividade que levem em conta variáveis como diminuição do tempo e valor da internação perioperatória e da probabilidade de eventos adversos relacionados à cirurgia. Todas as classes mais utilizadas foram avaliadas. Metodologia: Foi conduzido um estudo econômico de custo-efetividade, tendo como outcomes mitigar qualquer probabilidade de evento adverso relacionado ao pós-operatório de gastroplastia. Para a questão econômico, as bases BPS e CMED foram utilizadas e as bases de pesquisa Scielo, Schoolar Google e PubMed para os demais assuntos. Resultados: A associação mais custo-efetiva e custo-benefício foi dexametasona + ondansetrona, podendo ser estendida para mais uma classe medicamentosa dependendo da pontuação no escore de Apfel. Conclusão: Conclui-se que as recomendações são ferramentas valiosas para o anestesista, fundadas em evidências sólidas ao longo dos anos, que beneficia o profissional, a instituição e o paciente em questão.
Análise dos investimentos sociais da Petrobrás - uma comparação dos anos 2013 e 2018
Authors: Oliveira Riatla da Silva , Cunha Ctiana , Amorim Úrsula Adriane Fraga 
Published: November 2020

A Contabilidade é uma Ciência Social aplicada que busca, através da sua função social, prestar informações sobre as relações das empresas com a sociedade na qual ela está inserida, em um mesmo contexto social. Sendo assim, o objetivo do presente trabalho foi o de identificar o grau em investimentos sociais da Petrobrás em comparativo de intervalo de 5 anos. Para identificar o referido grau, foram utilizados os valores divulgados, pela empresa em investimento social sobre a Receita de Vendas Consolidada e o Lucro Antes do Imposto de Renda e Contribuição Social. A pesquisa mostrou que não há auditoria das informações. Foram encontradas informações sobre investimentos sociais com a mensuração de tributos incluídos dentro destes valores (excluindo os encargos sociais), prejudicando a apuração do grau em investimentos sociais. A empresa faz investimentos socioambientais, não identificando os valores sociais e os ambientais e realiza também os investimentos ambientais, os investimentos ambientais não foram levados em consideração.
Neuroendocrine tumour of the ampulla of Vater: a rare neoplasm at an atypical site
Authors: Abrar Zahid  , Danish Ali  , Muhammad Zubair  , Irfan Ahmed  , Tauseef Fatima  , Muhammad Farooq Afzal  
Published: November 2020

Abstract
The periampullary neuroendocrine tumour is an infrequently occurring tumour. Its prevalence among gastrointestinal neuroendocrine neoplasms is less than 0.3%, and less than 2% out of periampullary tumours. These neoplasms have relatively poor prognosis. Jaundice and pain in the abdomen are the early and most commonly occurring symptoms with weight loss being a late event. The carcinoid syndrome presents infrequently in periampullary neuroendocrine tumour and happens only if hepatic metastasis occurs. In this scenario, histopathology plays a paramount role in the diagnosis. Specific immunohistochemical staining is used for diagnosis while the treatment options are local excision, endoscopic excision and pancreaticoduodenectomy. Here is a case report of a 42-year-old patient who presented with complaint of obstructive jaundice for one month. Periampullary carcinoid tumour was diagnosed on biopsy, and she underwent Pancreaticoduodenectomy as treatment. Continuou...
Serratiopeptidase: A drug without clear benefits
Authors: Muhammad Umar Raza  , Nimra Shakeel  , Ramsha Shakeel  
Published: November 2020

Serratiopeptidase is a proteolytic enzyme produced by serratia species E15, isolated from the intestine of silkworm. It has become one of the most widely used medications by both physicians and surgeons and is said to have efficacy in reducing inflammation via the breakdown of various inflammatory mediators. [1] Serratiopeptidase is mostly prescribed in inflammatory illnesses and in some non-inflammatory disorders albeit less commonly due to its analgesic effects. It is even used very commonly in the post-operative period to improve healing and to reduce inflammation of the surgical wound. [2]
However, an online literature search on Medline, Cochrane library and Google scholar using the search words serratiopeptidase, serrapeptase, serralysin, serratiapeptase and proteolytic enzymes retrieved only small-scale, inadequately structured, studies reflecting some anti-inflammatory effects of serratiopeptidase, but most of these failed to demonstrate significant benefits from the drug.[3] Serratiopeptidase has a lower efficacy as compared to the NSAIDs as an analgesic but demonstrated greater anti-inflammatory effects than the NSAIDs.[4] Therefore, it is still not sufficiently efficacious to be used solely and rather, is almost always used in combination with NSAIDs to reduce pain symptoms. [5]
As a matter of fact, one of the authors’ of this letter had significant experience with the drug in treating seronegative spondyloarthropathy. The drug was used for about a week but no improvement was noted in the reduction of symptoms and the person remained severely disabled. Switching to meloxicam significantly showed good response.
In the light of above reports and observations, there is a dire need of conducting well-designed clinical trial-based studies for a wider spectrum of conditions and limit its use until its benefits and/or contraindications are substantially proven [3] Continuous...
Density of Aedes Aegypti Larves Based on Knowledge, Attitude and Action of Terminal Management in Daya Regional Terminal Kota Makassar
Authors: Indra Rusydi , Ibrahim Erniwati , Moedjiono ApikIndarty , M Syamsuar , Birawida Agus Bintara , Masni Masni 
Published: November 2020

Purpose: This study aims to determine the density of Aedes aegypti larvae based on the knowledge, attitudes and actions of terminal managers at the Regional Terminal Daya Makassar City.
Methods: The research design used was descriptive observational. There are two samples in this study, namely the container sample and the terminal manager sample. The sampling technique for containers used total sampling method and for terminal managers, purposive sampling method was used. Data were analyzed by univariate.
Results: The results of the analysis showed that the number of positive containers for larvae was 69 (CI = 33%) with a value of DF = 8 and was a high density category. A total of 9 respondents (39.1%) had good knowledge and 14 respondents (60.9%) had poor knowledge. A total of 10 respondents (43.5%) had a good attitude and as many as 13 respondents (56.5%) had a bad attitude. In terms of action, (4.3%) of the respondents reflected good, while 22 respondents (95.7%) had actions in the unfavorable category.
Conclusion: It is concluded that increasing public knowledge is essential to eradicate mosquito nests in the community. By enhancing the knowledge of the individuals, the PSN activities carried out routinely can break the life cycle of the mosquitoes that can cause DHF.The level of education that the terminal manager has, the better the ability to absorb the information provided will affect the knowledge held by the terminal manager.
Pengaruh Profitabilitas, Ukuran Perusahaan Dan Financial Leverage Terhadap Perataan Laba (Studi Pada Perusahaan Manufaktur yang Terdaftar di BEI Tahun 2014-2018)
Authors: Zulaika Wulandari  , Irvan Rolyesh Situmorang  
Published: November 2020

Penelitian ini bertujuan untuk mengetahui pengaruh profitabilitas, ukuran perusahaan, dan financial leverage terhadap perataan laba. Variabel profitabilitas, ukuran perusahaan, dan financial leverage sebagai variabel independen dan perataan laba sebagai variabel dependen. Jumlah sampel yang digunakan dalam penelitian ini adalah 26 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada tahun 2014 sampai 2018. Penelitian ini menggunakan data sekunder. Data dikumpulkan dengan menggunakan metode purposive sampling yang berdasarkan syarat-syarat tertentu. Data dianalisis dengan menggunakan model regresi linear. Hasil penelitian ini menunjukkan bahwa profitabilitas berpengaruh terhadap perataan laba, sedangkan ukuran perusahaan dan financial leverage tidak berpengaruh terhadap perataan laba.