bluuebunny/crossref_metadata_2025_split huggingface dataset:
The higher education space: connecting degree programs from individuals’ choices
Authors: Candia Cristian , Encarnação Sara , Pinheiro Flávio L. 
Published: December 2019

AbstractData on the applicants’ revealed preferences when entering higher education is used as a proxy to build the Higher Education Space (HES) of Portugal (2008–2015) and Chile (2006–2017). The HES is a network that connects pairs of degree programs according to their co-occurrence in the applicants’ preferences. We show that both HES network structures reveal the existence of positive assortment in features such as gender balance, application scores, unemployment levels, academic demand/supply ratio, geographical mobility, and first-year drop-out rates. For instance, if a degree program exhibits a high prevalence of female candidates, its nearest degree programs in the HES will also tend to exhibit a higher prevalence when compared to the prevalence in the entire system. These patterns extend up to two or three links of separation, vanishing, or inverting for increasing distances. Moreover, we show that for demand/supply ratio and application scores a similar pattern occurs for time variations. Finally, we provide evidence that information embedded in the HES is not accessible by merely considering the features of degree programs independently. These findings contribute to a better understanding of the higher education systems at revealing and leveraging its non-trivial underlying organizing principles. To the best of our knowledge, this is the first network science approach for improving decision-making and governance in higher education systems.
Effect of composition and structures on the elastic modulus of SiC fibers
Authors: Wang Yongshou , Wang Yifei , Wang Yingde 
Published: December 2019

High modulus SiC fibers can be used in complex working environment with alternating heat and cold. In this paper, SiC fibers with various oxygen contents and crystal size were fabricated by polymer-derived ceramics routes. The effects of oxygen content and crystal size on the elastic modulus of SiC fibers were studied in detail. It was found that the elastic modulus of SiC fibers can be improved by reducing the oxygen content and increasing the crystal size of SiC fibers when the crystal size was less than 2 nm. When the oxygen content decreased from 21.5 wt.% to 11.7 wt.%, the elastic modulus of SiC fibers was increased from 131 GPa to 167 GPa. Particularly, the highest elastic modulus of CVC treated hypoxic SiC fibers is close to 200 GPa when the crystallite size is about 2 nm.
Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells
Authors: Cserepes Mihály , Türk Dóra , Tóth Szilárd , Pape Veronika F.S. , Gaál Anikó , Gera Melinda , Szabó Judit E. , Kucsma Nóra , Várady György , Vértessy Beáta G. , Streli Christina , Szabó Pál T. , Tovari Jozsef , Szoboszlai Norbert , Szakács Gergely 
Published: December 2019

Abstract

Clinical evidence shows that following initial response to treatment, drug-resistant cancer cells frequently evolve and, eventually, most tumors become resistant to all available therapies. We compiled a focused library consisting of &gt;500 commercially available or newly synthetized 8-hydroxyquinoline (8OHQ) derivatives whose toxicity is paradoxically increased rather than decreased by the activity of P-glycoprotein (Pgp), a transporter conferring multidrug resistance (MDR). Here, we deciphered the mechanism of action of NSC297366 that shows exceptionally strong Pgp-potentiated toxicity. Treatment of cells with NSC297366 resulted in changes associated with the activity of potent anticancer iron chelators. Strikingly, iron depletion was more pronounced in MDR cells due to the Pgp-mediated efflux of NSC297366–iron complexes. Our results indicate that iron homeostasis can be targeted by MDR-selective compounds for the selective elimination of multidrug resistant cancer cells, setting the stage for a therapeutic approach to fight transporter-mediated drug resistance.

Significance:
Modulation of the MDR phenotype has the potential to increase the efficacy of anticancer therapies. These findings show that the MDR transporter is a “double-edged sword” that can be turned against resistant cancer.
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death
Authors: Ommer Johannes , Selfe Joanna L. , Wachtel Marco , O'Brien Eleanor M. , Laubscher Dominik , Roemmele Michaela , Kasper Stephanie , Delattre Olivier , Surdez Didier , Petts Gemma , Kelsey Anna , Shipley Janet , Schäfer Beat W. 
Published: December 2019

Abstract

The clinically aggressive alveolar rhabdomyosarcoma (RMS) subtype is characterized by expression of the oncogenic fusion protein PAX3-FOXO1, which is critical for tumorigenesis and cell survival. Here, we studied the mechanism of cell death induced by loss of PAX3-FOXO1 expression and identified a novel pharmacologic combination therapy that interferes with PAX3-FOXO1 biology at different levels. Depletion of PAX3-FOXO1 in fusion-positive (FP)-RMS cells induced intrinsic apoptosis in a NOXA-dependent manner. This was pharmacologically mimicked by the BH3 mimetic navitoclax, identified as top compound in a screen from 208 targeted compounds. In a parallel approach, and to identify drugs that alter the stability of PAX3-FOXO1 protein, the same drug library was screened and fusion protein levels were directly measured as a read-out. This revealed that inhibition of Aurora kinase A most efficiently negatively affected PAX3-FOXO1 protein levels. Interestingly, this occurred through a novel specific phosphorylation event in and binding to the fusion protein. Aurora kinase A inhibition also destabilized MYCN, which is both a functionally important oncogene and transcriptional target of PAX3-FOXO1. Combined treatment with an Aurora kinase A inhibitor and navitoclax in FP-RMS cell lines and patient-derived xenografts synergistically induced cell death and significantly slowed tumor growth. These studies identify a novel functional interaction of Aurora kinase A with both PAX3-FOXO1 and its effector MYCN, and reveal new opportunities for targeted combination treatment of FP-RMS.

Significance:
These findings show that Aurora kinase A and Bcl-2 family proteins are potential targets for FP-RMS.
MODERNIDADE E ALIENAÇÃO DO MUNDO EM HANNAH ARENDT
Authors: Dias Thiago 
Published: December 2019

Este artigo apresenta certos aspectos da crítica à modernidade feita por Hannah Arendt. O percurso se baseia na exposição das princi-pais razões pelas quais a autora afirma que a característica fundamental da era moderna é a alienação do mundo. Esta alienação tem sua origem no descobrimento da América, na Reforma protestante e, sobretudo, no par formado pela invenção do telescópio e a filosofia de Descartes. De-pois de indicar os tipos de alienação do mundo correspondentes a cada um destes eventos, com destaque para o papel da ciência neste proces-so, apresenta-se certos desdobramentos contemporâneos desta alienação que talvez permitam avançar a hipótese de que, de um ponto de vista arendtiano, a ideia de hipermodernidade é mais pertinente que a de pós-modernidade.
Routine Continuous Electrocardiographic Monitoring Following Percutaneous Coronary Interventions
Authors: Al-Hijji Mohammed A. , Gulati Rajiv , Bell Malcolm , Kaplan Revelee J. , Feind Jeanna L. , Lewis Bradley R. , Borah Bijan J. , Moriarty James P. , Yoon Park Jae , El Sabbagh Abdallah , Kanwar Ardaas , Barsness Gregory , Munger Thomas , Asirvatham Samuel , Lerman Amir , Singh Mandeep 
Published: December 2019

Background:
The clinical utility of routine electrocardiographic monitoring following percutaneous coronary interventions (PCI) is not well studied.

Methods:
We prospectively evaluated the incidence, cost, and the clinical implications of actionable arrhythmia alarms on telemetry monitoring following PCI. One thousand three hundred fifty-eight PCI procedures (989 [72.8%] for acute coronary syndrome and 369 [27.2%] for stable angina) on patients admitted to nonintensive care unit were identified and divided into 2 groups; group 1, patients with actionable alarms (AA) and group 2, patients with non-AA. AA included (1) ≥3 s electrical pause or asystole; (2) high-grade Mobitz type II atrioventricular block or complete heart block; (3) ventricular fibrillation; (4) ventricular tachycardia (>15 beats); (5) atrial fibrillation with rapid ventricular response; (6) supraventricular tachycardia (>15 beats). Primary outcomes were 30-day all-cause mortality. Cost-savings analysis was performed.

Results:

Incidence of AA was 2.2% (37/1672). Time from end of procedure to AA was 5.5 (0.5, 24.5) hours. Patients with AA were older, presented with acute congestive heart failure or non–ST-segment–elevation myocardial infarction, and had multivessel or left main disease. The 30-day all-cause mortality was significantly higher in patients with AA (6.5% versus 0.3% in non-AA [
P
<0.001]). Applying the standardized costing approach and tailored monitoring per the American Heart Association guidelines lead to potential cost savings of $622 480.95 for the entire population.

Conclusions:
AA following PCI were infrequent but were associated with increase in 30-day mortality. Following American Heart Association guidelines for monitoring after PCI can lead to substantial cost saving.
Right Hemispheric Homologous Language Pathways Negatively Predicts Poststroke Naming Recovery
Authors: Keser Zafer , Sebastian Rajani , Hasan Khader M. , Hillis Argye E. 
Published: December 2019

Background and Purpose—
Stroke is the leading cause of disability in United States, and aphasia is a common sequela after a left hemisphere stroke. Functional imaging and brain stimulation studies show that right hemisphere structures are detrimental to aphasia recovery but evidence from diffusion tensor imaging is lacking. We investigated the role of homologous language pathways in naming recovery after left hemispheric stroke.

Methods—
Patients with aphasia after a left hemispheric stroke underwent naming assessment using the Boston Naming Test and diffusion tensor imaging at the acute and chronic time points. We analyzed diffusion tensor imaging of right arcuate fasciculus and frontal aslant tracts. We used Wilcoxon rank-sum test to evaluate structural lateralization patterns and partial Spearman correlation/multivariate generalized linear model to determine the role of right arcuate fasciculus and frontal aslant tracts in naming recovery after controlling for confounders. Results were corrected for multiple comparisons.

Results—
On average, the structural integrity of left language pathways deteriorated more than their right homologs, such that there was rightward lateralization in the chronic stage. Regression/correlation analyses showed that greater preservation of tract integrity of right arcuate fasciculus was associated with poorer naming recovery.

Conclusions—
Our study provides preliminary evidence that preservation of right homologs of language pathways is associated with poor recovery of naming after a left hemispheric stroke, consistent with previous evidence that maintaining greater reliance on left hemisphere structures is associated with better language recovery.
Effect of a feedback system on the quality of 2-minute chest compression-only cardiopulmonary resuscitation: a randomised crossover simulation study
Authors: Wu Chunshuang , You Jingyu , Liu Shaoyun , Ying Lan , Gao Yuzhi , Li Yulin , Lu Xiao , Qian Anyu , Zhang Mao , Zhou Guangju 
Published: December 2019

Objective We evaluated the quality of 2-minute continuous chest compressions (CCCs) performed by emergency staff in 30-second intervals to determine the effect of a feedback system on maintaining the quality of CCCs. Methods Two hundred three physicians and nurses were randomised into two groups. Each participant performed 2-minute CCCs both with and without feedback. Group A performed CCCs under the guidance of a feedback device followed by performance without feedback, and Group B performed these tasks in reverse order. The primary outcome was the proportion of optimal compressions; i.e., compressions at both the correct rate (100–120 beats/minute) and correct depth (5–6 cm). Results During 2-minute CCCs, the proportion of optimal compressions was poor in personnel without feedback. The proportion of optimal compressions was unchanged and low from 2.4% (interquartile range, 0.0%–32.8%) in the first 30 seconds to 3.3% (0.0%–47.7%) in the last 30 seconds of the 2-minute period. Use of the feedback device significantly improved and maintained the quality of compressions from the first 30 seconds (53.3%; 29.2%–70.4%) to the last 30 seconds (82.8%; 50.8%–96.2%). Conclusion Use of the feedback device was helpful for maintaining the quality of CCCs.
The impact of language proficiency on the time course and neural basis of L2 semantic access in bilinguals
Authors: Liang Lijuan , Chen Baoguo 
Published: December 2019

Aims: The present study aimed to explore the impact of L2 proficiency on the time course and neural basis of L2 semantic access. Methodology: Two groups of participants with either high or low L2 proficiency performed a picture–word semantic matching task (i.e. consistent vs. inconsistent), with their event-related potentials (ERP) responses being recorded. Two stimulus types, L2 words and L1 words, were investigated in two separate blocks. Here the L1 words were tested as a control condition. Data and Analysis: The ERP epochs time-locked to the onset of the word were analyzed within 300–600 ms both at the surface (i.e. mean amplitude and peak latency) and the source (i.e. source localization) level. Findings/Conclusions: In the L2, a reliable N400 effect (i.e. semantic incongruity effect) was found for both high and low L2 proficiency bilinguals. However, the difference waves showed that the N400 peak latency was much shorter and the mean amplitude within 300–600 ms was much larger in bilinguals with higher L2 proficiency. Source localization analysis found left insula cortex (Brodmann area 13, Low > High) to be responsible for this proficiency effect (i.e. a decrease in the activation of left insula at a higher proficiency level). In the L1, a reliable N400 effect was found for both participant groups, and the two groups were matched in the N400 peak latency and amplitude, and its neural source. Originality: This study provides further evidence for the neural substrates underlying the modulation of L2 proficiency in semantic access by using a more sensitive task (i.e. picture–word matching task), and the current results revealed the engagement of left insula for the first time. Significance/Implications: The current findings suggest that L2 proficiency affects the time course and neural basis of L2 semantic access, probably through a modulation of the strength of “L2 word-to-concept” connections.
Family-centered practices in home-based support for families with children with an intellectual disability: Judgments of parents and professionals
Authors: Vanderkerken Lien , Heyvaert Mieke , Onghena Patrick , Maes Bea 
Published: December 2019

Background: The realization of the family-centered approach (FCA) in home-based support (HBS) for families with children with an intellectual disability (ID) in Flanders was investigated, and parents’ and family workers’ perspectives were compared. The relation between parents’ educational level, the family worker’s education, and his/her experience in HBS; and parents’ and family workers’ judgments on the realization of the FCA was considered. Method: Parents ( N = 58 families) and family workers ( N = 46) completed the helpgiving practices scale and the enabling practices scale. Results: The FCA was largely present, parents rated its realization higher than family workers. Considering family workers’ answers, parents’ educational level appeared an important factor for parental autonomy. Conclusions: The study confirms recent research on the realization of the FCA. Including different perspectives, a nuanced view on the realization of the FCA was obtained. Further research on the concrete meaning, interpretation, and elaboration of the FCA is needed.
Use of Biologics as an Adjunct Therapy to Arthroscopic Surgery for the Treatment of Femoroacetabular Impingement: A Systematic Review
Authors: Robinson Patrick G. , Murray Iain R. , Maempel Julian , Rankin Conor S. , Hamilton David , Gaston Paul 
Published: December 2019

Background: There has been a recent increase in the use of biologics in hip arthroscopy to assist in the management of femoroacetabular impingement (FAI). Purpose: To analyze the current use of biologics for the treatment of FAI and its associated lesions. Study Design: Systematic review; Level of evidence, 4. Methods: A search of the PubMed, Medline, and EMBASE databases was performed in March 2019 with use of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The criterion for inclusion was observational, published research articles studying the therapeutic use of biologics as an adjuvant therapy during arthroscopic surgery for FAI; treatments included bone marrow aspirate concentrate, mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), hyaluronic acid, growth factors, and autologous chondrocyte implantation (ACI) or autologous matrix-induced chondrogenesis (AMIC). Results: There were 9 studies that met the inclusion criteria, and a total of 674 patients were included across all studies. FAI was studied in all articles. Further, 7 studies (78%) also analyzed chondral injuries, and 3 studies also analyzed labral tears (33%). ACI or AMIC was used in 56% of studies and showed superior functional outcomes at short- and midterm follow-up versus debridement or microfracture. PRP did not improve the outcome of labral repairs at short-term follow-up. Conclusion: The current literature regarding biologic adjuncts in hip arthroscopy is varied in quality, with only one level 1 study. The use of ACI/AMIC for medium-sized chondral lesions showed promising results in individual studies; however, these were of lower quality. To enable comparisons among future studies, investigators must ensure accuracy in the reporting of biologic preparations and formulations used and homogeneity in the type and severity of lesion treated.
More humility, less counterproductive work behaviors? The role of interpersonal justice and trust
Authors: Wang Yue , Luo Wenhao , Zhang Jing , Guo Yirong 
Published: December 2019

AbstractLeader humility has emerged as an important topic in understanding the role of leadership in organizations in recent years. Though it was found to enhance subordinates’ work performance and positive work behaviors, we are unaware of the psychological mechanism and boundary conditions underlying leader humility and employees’ negative behaviors toward leaders. Drawing on social exchange theory and using a multistage sample including 273 employees and 55 supervisors in China, we demonstrated a negative indirect effect between leader humility and subordinates’ counterproductive work behaviors toward supervisors (CWB-S) via interpersonal justice and trust in supervisor. Furthermore, we find that leader political skill moderates the effect of leader humility on interpersonal justice and trust in supervisor. The indirect effect of leader humility on subordinates’ CWB-S through interpersonal justice is stronger when leader political skill is high, suggesting a moderated mediation model. Finally, we discuss the theoretical contributions and practical implications of this study, and highlight future directions for research on leader humility.
VariFAST: a variant filter by automated scoring based on tagged-signatures
Authors: Zhang Hang , Wang Ke , Zhou Juan , Chen Jianhua , Xu Yizhou , Wang Dong , Li Xiaoqi , Sun Renliang , Zhang Mancang , Wang Zhuo , Shi Yongyong 
Published: December 2019

Abstract
Background
Variant calling and refinement from whole genome/exome sequencing data is a fundamental task for genomics studies. Due to the limited accuracy of NGS sequencing and variant callers, IGV-based manual review is required for further false positive variant filtering, which costs massive labor and time, and results in high inter- and intra-lab variability.

Results
To overcome the limitation of manual review, we developed a novel approach for Variant Filter by Automated Scoring based on Tagged-signature (VariFAST), and also provided a pipeline integrating GATK Best Practices with VariFAST, which can be easily used for high quality variants detection from raw data. Using the bam and vcf files, VariFAST calculates a v-score by sum of weighted metrics causing false positive variations, and marks tags in the manner of keeping high consistency with manual review, for each variant. We validated the performance of VariFAST for germline variant filtering using the benchmark sequencing data from GIAB, and also for somatic variant filtering using sequencing data of both malignant carcinoma and benign adenomas as well. VariFAST also includes a predictive model trained by XGBOOST algorithm for germline variants refinement, which reveals better MCC and AUC than the state-of-the-art VQSR, especially outcompete in INDEL variant filtering.

Conclusion
VariFAST can assist researchers efficiently and conveniently to filter the false positive variants, including both germline and somatic ones, in NGS data analysis. The VariFAST source code and the pipeline integrating with GATK Best Practices are available at https://github.com/bioxsjtu/VariFAST.
LMAP_S: Lightweight Multigene Alignment and Phylogeny eStimation
Authors: Maldonado Emanuel , Antunes Agostinho 
Published: December 2019

Abstract
Background
Recent advances in genome sequencing technologies and the cost drop in high-throughput sequencing continue to give rise to a deluge of data available for downstream analyses. Among others, evolutionary biologists often make use of genomic data to uncover phenotypic diversity and adaptive evolution in protein-coding genes. Therefore, multiple sequence alignments (MSA) and phylogenetic trees (PT) need to be estimated with optimal results. However, the preparation of an initial dataset of multiple sequence file(s) (MSF) and the steps involved can be challenging when considering extensive amount of data. Thus, it becomes necessary the development of a tool that removes the potential source of error and automates the time-consuming steps of a typical workflow with high-throughput and optimal MSA and PT estimations.

Results
We introduce LMAP_S (Lightweight Multigene Alignment and Phylogeny eStimation), a user-friendly command-line and interactive package, designed to handle an improved alignment and phylogeny estimation workflow: MSF preparation, MSA estimation, outlier detection, refinement, consensus, phylogeny estimation, comparison and editing, among which file and directory organization, execution, manipulation of information are automated, with minimal manual user intervention. LMAP_S was developed for the workstation multi-core environment and provides a unique advantage for processing multiple datasets. Our software, proved to be efficient throughout the workflow, including, the (unlimited) handling of more than 20 datasets.

Conclusions
We have developed a simple and versatile LMAP_S package enabling researchers to effectively estimate multiple datasets MSAs and PTs in a high-throughput fashion. LMAP_S integrates more than 25 software providing overall more than 65 algorithm choices distributed in five stages. At minimum, one FASTA file is required within a single input directory. To our knowledge, no other software combines MSA and phylogeny estimation with as many alternatives and provides means to find optimal MSAs and phylogenies. Moreover, we used a case study comparing methodologies that highlighted the usefulness of our software. LMAP_S has been developed as an open-source package, allowing its integration into more complex open-source bioinformatics pipelines. LMAP_S package is released under GPLv3 license and is freely available at https://lmap-s.sourceforge.io/.