bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous Involvement in Plasma Cell Myeloma
Authors: Panse Gauri , Subtil Antonio , McNiff Jennifer M , Glusac Earl J , Ko Christine J , Galan Anjela , Myung Peggy , Xu Mina L 
Published: June 2020

Abstract

Objectives
Plasma cell myeloma (PCM) involving skin is rare and occurs in 1% to 4% of patients with PCM. We evaluated the clinicopathologic features, cytogenetic findings and clinical follow-up in a series of PCM cases with cutaneous involvement.

Methods
Cases of PCM with cutaneous involvement were retrospectively reviewed with clinical data.

Results
Skin involvement in PCM occurred in older individuals (mean, 75 years) and was more frequent in men (7/10 patients). All cases showed bone marrow involvement preceding the cutaneous lesions. Histopathologically, the infiltrate was plasmacytic (n = 5) or primitive or plasmablastic (n = 4), and 1 case showed predominantly lymphoplasmacytic features with cyclin D1 immunoreactivity and CCND1 gene rearrangement. Concurrent amyloid deposition was seen in one biopsy, and another case demonstrated coexisting squamous cell carcinoma. The most common immunophenotype was CD138+, CD20–, and CD56+ with light chain restriction. Cytogenetic analysis (available for 7 cases) showed multiple hyperdiploid abnormalities. Follow-up was available for 8 cases (mean, 42 months; range, 11-156 months) and showed short-term disease-related death in 7 of 8 patients.

Conclusions
Cutaneous involvement in PCM demonstrates a diverse cytomorphologic spectrum with plasmacytic, plasmablastic, or lymphoplasmacytic features and may show concurrent amyloid deposition or neoplasms such as squamous cell carcinoma. Cutaneous involvement typically occurs late in the course of the disease and likely portends poor outcome.
A Case Report of Nicolau Syndrome After Aesthetic Breast Surgery: A Review of the Literature and Introduction to a New Treatment Modality
Authors: Gal Shaili , Dart Paul E , Movassaghi Kiya 
Published: June 2020

Abstract

Nicolau syndrome (NS) is a rare iatrogenic syndrome usually following intramuscular (IM) injection of various described medications. The typical presentation involves immediate injection site pain and development of a livedoid reticular patch, which can progress to muscle necrosis requiring surgical debridement. The pathophysiology is unclear, although vasoconstrictive etiologies have been implicated. Treatment ranges from supportive care to surgical debridement. The authors present a case report of this syndrome as well as a review of the literature and introduction to a new treatment modality. NS in a 52-year-old woman following IM injection of Demerol and Phenergan to address pain and nausea before discharge is reported. This occurred in the post-anesthesia care unit after aesthetic breast surgery in an ambulatory surgery center. Our patient had immediate injection site pain and a hemorrhagic patch was evident on her physical examination the following day. With local care and hyperbaric oxygen therapy, her lesion improved in appearance. However, she continued to have debilitating pain and was referred to a specialist for osteopathic manipulative therapy (OMT), which had the greatest impact on her pain level. After multi-modal therapy was initiated, the syndrome ultimately resolved without the need for surgical debridement. However, she continues to experience pain and ambulates with a limp due to muscle atrophy. NS is a rare diagnosis that can have devastating complications that can be averted by early recognition and initiation of treatment modalities. In this case, the authors introduced OMT as a new treatment modality, with the potential to improve the progression of this syndrome.

Level of Evidence: 5
TDAview: an online visualization tool for topological data analysis
Authors: Walsh Kieran , Voineagu Mircea A , Vafaee Fatemeh , Voineagu Irina 
Published: June 2020

Abstract

Summary
TDAview is an online tool for topological data analysis (TDA) and visualization. It implements the Mapper algorithm for TDA and provides extensive graph visualization options. TDAview is a user-friendly tool that allows biologists and clinicians without programming knowledge to harness the power of TDA. TDAview supports an analysis and visualization mode in which a Mapper graph is constructed based on user-specified parameters, followed by graph visualization. It can also be used in a visualization only mode in which TDAview is used for visualizing the data properties of a Mapper graph generated using other open-source software. The graph visualization options allow data exploration by graphical display of metadata variable values for nodes and edges, as well as the generation of publishable figures. TDAview can handle large datasets, with tens of thousands of data points, and thus has a wide range of applications for high-dimensional data, including the construction of topology-based gene co-expression networks.

Availability and implementation
TDAview is a free online tool available at https://voineagulab.github.io/TDAview/. The source code, usage documentation and example data are available at TDAview GitHub repository: https://github.com/Voineagulab/TDAview.
Does robot-assisted minimally invasive oesophagectomy have superiority over thoraco-laparoscopic minimally invasive oesophagectomy in lymph node dissection?
Authors: Li Xiao-Kun , Xu Yang , Zhou Hai , Cong Zhuang-Zhuang , Wu Wen-Jie , Qiang Yong , Shen Yi 
Published: June 2020

Summary
Although robotic techniques have been used for oesophagectomy for many years, whether robot-assisted minimally invasive oesophagectomy (RAMIE) can actually improve outcomes and surpass thoraco-laparoscopic minimally invasive oesophagectomy (MIE) in the success rate of lymph node dissection remains to be empirically demonstrated. Therefore, we performed this systematic review and meta-analysis of case–control studies to systematically compare the effect of lymph node dissection and the incidence of vocal cord palsy between RAMIE and MIE. The PubMed, EMBASE, and Web of Science databases were systematically searched up to December 1, 2019, for case–control studies that compared RAMIE with MIE. Thirteen articles were included, with a total of 1,749 patients with esophageal cancer, including 866 patients in the RAMIE group and 883 patients in the MIE group. RAMIE yielded significantly larger numbers of total dissected lymph nodes (WMD = 1.985; 95% CI, 0.448–3.523; P = 0.011) and abdominal lymph nodes (WMD = 1.686; 95% CI, 0.420–2.951; P = 0.009) as well as lymph nodes along RLN (WMD = 0.729; 95% CI, 0.348–1.109; P &lt; 0.001) than MIE. Additionally, RAMIE could significantly decrease estimated blood loss (WMD = -11.208; 95% CI, -19.358 to -3.058; P = 0.007) and the incidence of vocal cord palsy (OR = 0.624; 95% CI, 0.411–0.947; P = 0.027) compared to MIE. Compared with MIE, RAMIE resulted in a higher total lymph node yield and a higher lymph node yield in the abdomen and along RLN, along with reduced blood loss during surgery and the incidence of vocal cord palsy. Therefore, RAMIE could be considered to be a standard treatment, with less blood loss, lower incidence of vocal cord palsy, and more radical lymph node dissection, exhibiting superiority over MIE.
Guidance for Restarting Inflammatory Bowel Disease Therapy in Patients Who Withheld Immunosuppressant Medications During COVID-19
Authors: Siegel Corey A , Christensen Britt , Kornbluth Asher , Rosh Joel R , Kappelman Michael D , Ungaro Ryan C , Johnson Douglas Forsyth , Chapman Scott , Wohl David A , Mantzaris Gerassimos J 
Published: June 2020

AbstractPatients with inflammatory bowel diseases [IBD] are frequently treated with immunosuppressant medications. During the coronavirus disease 2019 [COVID-19] pandemic, recommendations for IBD management have included that patients should stay on their immunosuppressant medications if they are not infected with the severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], but to temporarily hold these medications if symptomatic with COVID-19 or asymptomatic but have tested positive for SARS-CoV-2. As more IBD patients are infected globally, it is important to also understand how to manage IBD medications during convalescence while an individual with IBD is recovering from COVID-19. In this review, we address the differences between a test-based versus a symptoms-based strategy as related to COVID-19, and offer recommendations on when it is appropriate to consider restarting IBD therapy in patients testing positive for SARS-CoV-2 or with clinical symptoms consistent with COVID-19. In general, we recommend a symptoms-based approach, due to the current lack of confidence in the accuracy of available testing and the clinical significance of prolonged detection of virus via molecular testing.
Optimized approximate inverse Laplace transform for geo-deformation computation in viscoelastic Earth model
Authors: Tang He , Zhang Lan , Chang Le , Sun Wenke 
Published: June 2020

SUMMARY
Integral transformations, especially the inverse Laplace transform, are powerful techniques for resolving a wide range of geophysical and geodynamic simulation problems in viscoelastic materials. The exact location or distribution range of poles of the image function in a complex plane is usually necessary for applying numerical algorithms such as contour integration. Unfortunately, there are innumerable poles (such as those of post-seismic deformations) in a realistic Earth model with continuous stratification, finite compressibility and self-gravitation. Here, an optimized method to effectively calculate the inverse Laplace transform is presented. First, the integral kernel is approximated as a rational function with two parameters (a and m). Thereafter, the residue theorem is analytically applied to the approximated integrand. Finally, a series formula of the inverse Laplace transform sampling of image functions along a contour line parallel to the image axis is obtained. The proposed approximate scheme of the inverse Laplace transform is discussed by some common geophysical signals and the optimized selection of two parameters (a = 6 and m = 4) is conducted after a detailed analysis. The proposed method is anticipated as being able to help performing certain theoretical studies related to geodynamic problems with viscoelastic deformations.
Larval Dispersal Modeling Suggests Limited Ecological Connectivity Between Fjords on the West Antarctic Peninsula
Authors: Ziegler Amanda F , Hahn-Woernle Lisa , Powell Brian , Smith Craig R 
Published: June 2020

Synopsis
Larval dispersal is a key process for community assembly and population maintenance in the marine environment, yet it is extremely difficult to measure at ecologically relevant spatio-temporal scales. We used a high-resolution hydrodynamic model and particle-tracking model to explore the dispersal of simulated larvae in a hydrographically complex region of fjords on the West Antarctic Peninsula. Modeled larvae represented two end members of dispersal potential observed in Antarctic benthos resulting from differing developmental periods and swimming behavior. For simulations of low dispersing larvae (pre-competency period = 8 days, settlement period = 15 days, swimming downward) self-recruitment within fjords was important, with no larval settlement occurring in adjacent fjords &lt;50 km apart. For simulations of highly dispersing organisms (pre-competency period = 35–120 days, settlement period = 30–115 days, no swimming behavior), dispersal between fjords occurred when larvae were in the water column for at least 35 days, but settlement was rarely successful even for larvae spending up to 150 days in the plankton. The lack of ecological connectivity between fjords within a single spawning event suggests that these fjords harbor ecologically distinct populations in which self-recruitment may maintain populations, and genetic connectivity between fjords is likely achieved through stepping-stone dispersal. Export of larvae from natal fjord populations to the broader shelf region (&gt;100 km distance) occurred within surface layers (&lt;100 m depth) and was enhanced by episodic katabatic wind events that may be common in glaciomarine fjords worldwide.
A lumped-parameter model for kidney pressure during stone removal
Authors: Williams J G , Rouse L , Turney B W , Waters S L , Moulton D E 
Published: June 2020

AbstractIn this paper, we consider a lumped-parameter model to predict renal pressures and flow rate during a minimally invasive surgery for kidney stone removal, ureterorenoscopy. A ureteroscope is an endoscope designed to work within the ureter and the kidney and consists of a long shaft containing a narrow, cylindrical pipe, called the working channel. Fluid flows through the working channel into the kidney. A second pipe, the ‘access sheath’, surrounds the shaft of the scope, allowing fluid to flow back out of the urinary system. We modify and extend a previously developed model ( Oratis et al., 2018) through the use of an exponential, instead of linear, constitutive law for kidney compliance and by exploring the effects of variable flow resistance, dependent on the presence of auxiliary ‘working tools’ in the working channel and the cross-sectional shapes of the tools, working channel, scope shaft and access sheath. We motivate the chosen function for kidney compliance and validate the model predictions, with ex vivo experimental data. Although the predicted and measured flow rates agree, we find some disagreement between theory and experiment for kidney pressure. We hypothesize that this is caused by spatial pressure variation in the renal pelvis, i.e. unaccounted for in the lumped-parameter model. We support this hypothesis through numerical simulations of the steady Navier–Stokes equations in a simplified geometry. We also determine the optimal cross-sectional shapes for the scope and access sheath (for fixed areas) to minimize kidney pressure and maximize flow rate.
Fast and spectrally accurate numerical methods for perforated screens (with applications to Robin boundary conditions)
Authors: Colbrook Matthew J , Priddin Matthew J 
Published: June 2020

AbstractThis paper considers the use of compliant boundary conditions to provide a homogenized model of a finite array of collinear plates, modelling a perforated screen or grating. While the perforated screen formally has a mix of Dirichlet and Neumann boundary conditions, the homogenized model has Robin boundary conditions. Perforated screens form a canonical model in scattering theory, with applications ranging from electromagnetism to aeroacoustics. Interest in perforated media incorporated within larger structures motivates interrogating the appropriateness of homogenized boundary conditions in this case, especially as the homogenized model changes the junction behaviour considered at the extreme edges of the screen. To facilitate effective investigation we consider three numerical methods solving the Helmholtz equation: the unified transform and an iterative Wiener–Hopf approach for the exact problem of a set of collinear rigid plates (the difficult geometry of the problem means that such methods, which converge exponentially, are crucial) and a novel Mathieu function collocation approach to consider a variable compliance applied along the length of a single plate. We detail the relative performance and practical considerations for each method. By comparing solutions obtained using homogenized boundary conditions to the problem of collinear plates, we verify that the constant compliance given in previous theoretical research is appropriate to gain a good estimate of the solution even for a modest number of plates, provided we are sufficiently far into the asymptotic regime. We further investigate tapering the compliance near the extreme endpoints of the screen and find that tapering with $\tanh $ functions reduces the error in the approximation of the far field (if we are sufficiently far into the asymptotic regime). We also find that the number of plates and wavenumber has significant effects, even far into the asymptotic regime. These last two points indicate the importance of modelling end effects to achieve highly accurate results.
Increasing dietary tryptophan in conjunction with decreasing other large neutral amino acids increases weight gain and feed intake in weaner pigs regardless of experimental infection with enterotoxigenic Escherichia coli
Authors: Sterndale Samantha O , Miller David W , Mansfield Josie P , Kim Jae C , Pluske John R 
Published: June 2020

Abstract
Dietary tryptophan (Trp) is a precursor for serotonin, a neuromediator involved in stress responses. Tryptophan competes with other large neutral amino acids (LNAA: tyrosine, isoleucine, leucine, valine, and phenylalanine) to cross the blood–brain barrier; therefore, the regulation of circulating LNAA can influence Trp availability in the cortex and serotonin biosynthesis. The hypothesis examined in this study was that increased supplementation of dietary Trp and a reduction in LNAA for weaned pigs experimentally infected with enterotoxigenic Escherichia coli (ETEC; F4) will increase Trp availability in plasma and reduce indices of the stress response, which will translate to reduced production losses. At 21 ± 3 d of age (mean ± SEM), 96 male pigs (Large White × Landrace) weighing 6.3 ± 0.98 kg (mean ± SEM) were individually penned and allocated to a 4 × 2 factorial arrangement of treatments, with respective factors being 1) four dietary standardized ileal digestible (SID) Trp and LNAA contents, being HTrpHLNAA (Low Trp-High LNAA; 0.24% SID Trp: 5.4% SID LNAA), HTrpHLNAA (Low Trp-Low LNAA; 0.24% SID Trp: 4.6% SID LNAA), HTrpHLNAA (High Trp-High LNAA; 0.34% SID Trp: 5.4% SID LNAA), and HTrpHLNAA (High Trp-Low LNAA; 0.34% SID Trp: 4.6% SID LNAA), and 2) without/with ETEC infection. Pigs were orally infected with 0.8 mL (3.6 × 109 CFU/mL) ETEC at days 7 and 8 after weaning. Pigs fed diets high in Trp irrespective of the level of LNAA (HTrpHLNAA and HTrpLLNAA) had higher plasma Trp concentrations (P &lt; 0.001) and a Trp:LNAA ratio (P &lt; 0.001) before infection and 6 d after infection. Following infection, noninfected pigs had higher plasma Trp (P = 0.03) and a Trp:LNAA ratio (P = 0.004) compared with pigs infected with ETEC. Plasma cortisol levels after infection were higher in ETEC-infected pigs (P = 0.05) and altering dietary Trp and LNAA concentrations did not influence (P &gt; 0.05) plasma cortisol. Pigs fed diet HTrpLLNAA had higher serum serotonin levels 24 h after infection (P = 0.02) compared with pigs fed diets LTrpLLNAA and HTrpHLNAA. Similarly, pigs fed diet HTrpLLNAA had a higher (P = 0.02) average daily gain during the 3-wk study. Overall, average daily feed intake tended to be higher in pigs fed an HTrpLLNAA diet compared with the other diets (P = 0.08). These results suggest that the increased supplementation of dietary Trp with reduced LNAA increased circulating Trp levels that, in turn, likely caused higher serum serotonin levels, irrespective of infection with ETEC, and improved aspects of post-weaning performance.
Production planning and scheduling problem of continuous parallel lines with demand uncertainty and different production capacities
Authors: Bhosale Kailash Changdeorao , Pawar Padmakar Jagannath 
Published: June 2020

Abstract
Production planning and scheduling problems are highly interdependent as scheduling provides optimum allocation of resources and planning is an optimum utilization of these allocated resources to serve multiple customers. Researchers have solved production planning and scheduling problems by the sequential method. But, in this case, the solution obtained by the production planning problem may not be feasible for scheduling method. Hence, production planning and scheduling problems must be solved simultaneously. Therefore, in this work, a mathematical model is developed to integrate production planning and scheduling problems. The solution to this integrated planning and scheduling problem is attempted by using a discrete artificial bee colony (DABC) algorithm. To speed up the DABC algorithm, a k-means clustering algorithm is used in the initial population generation phase. This k-means clustering algorithm will help to converge the algorithm in lesser time. A real-life case study of a soap manufacturing industry is presented to demonstrate the effectiveness of the proposed approach. An objective function to minimize overall cost, which comprises the processing cost, material cost, utility cost, and changeover cost, is considered. The results obtained by using DABC algorithm are compared with those obtained by CPLEX software. There is a saving of ₹2 23 324 for weeks 1–4 in overall cost compared with the results obtained by using CPLEX software.
The Effects of Population Density on the Incidence of Developmental Deformities in Chemosensory Organs of Tobacco Hornworm Larvae (Lepidoptera: Sphingidae)
Authors: Hanson Frank , Stanwyck Elizabeth , Bohorquez Alexander 
Published: June 2020

Abstract
Cultures of Manduca sexta Johanssen in our laboratory were found to have larvae with missing or deformed mouthparts or antennae. Hypothesizing that these developmental deformities were caused by crowded rearing conditions, we reared larvae in four different population densities and recorded the incidence (% of larvae affected) and types of chemoreceptor deformities. Results showed that the incidence of these deformities was directly proportional to larval population density. Deformities of the maxilla and palp were the most frequent, followed by those of the antenna, epipharynx and maxillary styloconica. Life history traits of larval mass, food consumption, and rate of development were inversely related to larval density for both normal and deformed larvae. We discuss possible causes and mechanisms of these deformities and of changes to life history traits.
A Moving Target—Vancomycin Therapeutic Monitoring
Authors: Burns Alaina N , Goldman Jennifer L 
Published: June 2020

AbstractTherapeutic drug monitoring (TDM) has been a common practice to optimize efficacy and safety of vancomycin. While vancomycin trough-only TDM has widely been integrated into pediatric clinical practice since 2009, recently updated vancomycin TDM guidelines published in March 2020 recommend area under the curve (AUC) based TDM for vancomycin instead of trough-only TDM. In this review, we discuss the rationale behind the change in TDM recommendations, describe two approaches for calculating vancomycin AUC in clinical practice, and address considerations for integrating vancomycin AUC TDM into pediatric clinical practice. Our primary goal is to provide pediatric clinicians with a resource for implementing vancomycin AUC monitoring into clinical care.
Obesity and ventral hernia in the context of drug addiction and mental instability: a complex scenario successfully treated with preoperative progressive pneumoperitoneum
Authors: Moyón C F Xavier , Molina Gabriel A , Rojas Christian L , Moyón C Miguel A , Tufiño Jorge F , Cárdenas Andrés , Mafla Oscar L , Camino John E , Basantes Ligia Elena , Villacis Marcelo Stalin 
Published: June 2020

Abstract
Surgery in loss of domain hernia can result in high morbidity and mortality. Chronic muscle retraction along with the reduced volume of the peritoneal cavity can lead to potential problems such as abdominal compartment syndrome, ventilatory restriction and an elevated risk of hernia recurrence. This is affected even further by obesity; a high body mass index is strongly associated with poor outcomes after ventral hernia repair. In these individuals, preoperative preparation is vital as it can reduce surgical risks and improve patients’ outcomes. There are many strategies available. Nonetheless, an individualized case approach by a multidisciplinary team is crucial to accurately treat this troublesome pathology. We present the case of a 41-year-old obese patient with a loss of domain ventral hernia. As he had a drug addiction and several psychologic difficulties, a tailored approach was needed to successfully treat the hernia. After preoperative preparation and surgery, the patient underwent full recovery.