bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower executive functioning predicts steeper subsequent decline in well-being only in young-old but not old-old age
Authors: Ihle Andreas , Ghisletta Paolo , Gouveia Élvio R. , Gouveia Bruna R. , Oris Michel , Maurer Jürgen , Kliegel Matthias 
Published: July 2020

Objectives: From a longitudinal perspective, the direction of the relationship between cognitive functioning and well-being in old age, both conceptually and empirically, is still under debate. Therefore, we aimed to disentangle the different longitudinal relationship patterns proposed and whether those differed between young-old and old-old adults. Methods: We used latent change score modeling based on longitudinal data from 1,040 older adults ( M = 74.54 years at Time 1 [T1], median = 73 years) to analyze reciprocal lead–lag relationships over 6 years in executive functioning (trail making test [TMT] completion time) and well-being (life satisfaction), taking into account chronological age, sex, education, leisure activities, and chronic diseases. Results: In young-old adults (<73 years), longer TMT completion time at T1 (i.e., lower executive functioning status) significantly predicted steeper subsequent decline in well-being. This was not the case for old-old adults (≥73 years), for whom this relationship was significantly different from that of the young-old (moderation effect). In either group, well-being status at T1 did not predict changes in TMT completion time. Discussion: Lower executive functioning may predict a subsequent decline in well-being in young-old adults only. Wider implications in a context of promotion of healthy aging are discussed.
Mild cognitive impairment, dementia, and cognitive dysfunction screening using machine learning
Authors: Yim Daehyuk , Yeo Tae Young , Park Moon Ho 
Published: July 2020

Objective To develop a machine learning algorithm to identify cognitive dysfunction based on neuropsychological screening test results. Methods This retrospective study included 955 participants: 341 participants with dementia (dementia), 333 participants with mild cognitive impairment (MCI), and 341 participants who were cognitively healthy. All participants underwent evaluations including the Mini-Mental State Examination and the Montreal Cognitive Assessment. Each participant’s caregiver or informant was surveyed using the Korean Dementia Screening Questionnaire at the same visit. Different machine learning algorithms were applied, and their overall accuracies, Cohen’s kappa, receiver operating characteristic curves, and areas under the curve (AUCs) were calculated. Results The overall screening accuracies for MCI, dementia, and cognitive dysfunction (MCI or dementia) using a machine learning algorithm were approximately 67.8% to 93.5%, 96.8% to 99.9%, and 75.8% to 99.9%, respectively. Their kappa statistics ranged from 0.351 to 1.000. The AUCs of the machine learning models were statistically superior to those of the competing screening model. Conclusion This study suggests that a machine learning algorithm can be used as a supportive tool in the screening of MCI, dementia, and cognitive dysfunction.
Defining ‘undersizing’ in short-stem total hip arthroplasty: the importance of sufficient contact with the lateral femoral cortex
Authors: Kutzner Karl P , Freitag Tobias , Bieger Ralf 
Published: July 2020

Introduction: Undersizing is 1 of the main reasons for early implant failure. Adequate sizing in short-stem total hip arthroplasty can be challenging and, so far, lacks key decision criteria. Methods: We included 191 calcar-guided short stems. All patients underwent standardised digital anteroposterior imaging pre- and post-surgery and during follow-up. Preoperative planning was performed digitally. Planned stem sizes were retrospectively assessed and compared with the implanted sizes. Additionally, adequate sizing was analysed by determining whether the stem made intraoperative contact with the lateral distal femoral cortex. Implant migration was assessed by Ein-Bild-Roentgen-Analysis Femoral-Component-Analysis 5 years after surgery. Influence of different Dorr types and postoperative centrum-collum-diaphyseal angle (CCD) categories on lateral femoral cortical contact were analysed. Additionally, the Harris Hip Score (HHS) was assessed at final follow-up. Stem-revision rate was documented. Results: Implanted stems were at least 2 sizes smaller than those at the preoperative planning in 49 (25.7%) cases. The stem made contact with the lateral distal femoral cortex in only 130 hips (68.1%). Mean subsidence was significantly higher in the no-contact group (2.07 mm, range −7.7 to 1.7) than in the contact group (1.23 mm, range −4.5 to 1.8) at the final follow-up ( p = 0.0018). Stems at least 2 sizes smaller than those at preoperative planning showed a significantly higher prevalence of non-contact (46.9% vs. 26.8%) ( p = 0.009). Those undersized stems were more likely found in varus hips. No influence of the Dorr classification and the different CCD categories on the probability of achieving sufficient cortical contact was found. HHS showed no intergroup differences. Conclusions: Stems that did not make intraoperative contact with the lateral femoral cortex showed significantly increased axial migration at mid-term follow-up. Thus, the investigated criteria regarding the definition of undersizing in short-stem THA should be acknowledged. No obvious mid-term consequences were noted regarding revision rate. Long-term results are mandatory.
Peer engagement in toddlers with autism: Community implementation of dyadic and individual Joint Attention, Symbolic Play, Engagement, and Regulation intervention
Authors: Shire Stephanie Y , Shih Wendy , Bracaglia Suzanne , Kodjoe Maria , Kasari Connie 
Published: July 2020

Center-based classroom community interventions create opportunities for young children with autism to connect with peers. Yet, there has been little examination of the peer interactions of toddlers with autism who experience core challenges in social communication and play skills that may create barriers to successful peer interactions. Classrooms of toddlers were randomized to an experimental social communication intervention including peers or to the standard individual (adult–child) social communication intervention. Both toddlers in peer and no peer conditions demonstrated significant gains in social communication and play. Toddlers with greater receptive language and combination and presymbolic play skills were most likely to demonstrate peer engagement. Lay Abstract Although young children may participate in education and intervention programs that take place in classrooms or groups, there is little information about how toddlers with special needs, and specifically toddlers with autism, are engaging with their peers. This study takes place in a public center-based early intervention program for toddlers with autism. Classrooms of toddlers were randomly assigned to an individual social communication intervention or the same intervention adapted to include a peer. Children in both groups made gains in social communication and play skills. Children who had the peer intervention were more engaged with peers when an adult was present, but not when the children were unsupported. This article adds information about early skills that may be important for children to master so that they have more success when trying to interact with their peers. These skills include understanding language (referred to as “receptive language” at 12 months or more) and play skills including building and stacking (referred to as “combination play”—for example, building with blocks or completing a puzzle) and extending familiar actions to themselves, others, and figures (referred to as “presymbolic play”—for example, putting a bottle to the doll or to themselves). Understanding which skills to target can help practitioners focus their instruction to build children’s skills toward connecting with peers through play.
Investigation of fatigue behavior of centrifuged series 3000 Al with addition of 26 wt% Cu
Authors: Mehditabar Aref , Vahdat Seyed E , Rahimi Gholam-Hossein 
Published: July 2020

More than 70% of mechanical parts in a wide range of engineering fields fail by fatigue. In addition, centrifugal casting is identified as the most effective casting technique for production of high performance cylindrical parts. In this regard, the present work aims to investigate the fatigue behavior of series 3000 Al with addition of 26 wt% Cu produced through horizontal centrifugal casting method. Microstructure characterizations are precisely studied using scanning transmission electron microscopy and field emission scanning electron microscopy in conjunction with image analyzer software. Also, compressive behavior, hardness, coefficient of thermal expansion, and wear rate ( Wr) are measured applying Zwick Z100, Vickers hardness, DIL 805A/D, and pin-on-disc machines, respectively. The results indicate that the main intermetallic compound is Al2Cu-based particle, and a volume fraction of 31 vol.% is obtained. Besides, the compressive strength of 460 MPa, elastic modulus of 10.986 GPa, hardness of 152 HV, coefficient of thermal expansion of 1.7 × 10−5 1/°C, and wear resistance of 3.3 × 10−6 g/mm2 are measured. Finally, the four-point bending fatigue test is performed and the fatigue ratio of 0.109 at about 106 cycles to failure is obtained.
Good efficacy and safety of vedolizumab in Crohn’s disease and ulcerative colitis in a real-world scenario
Authors: Zingone Fabiana , Barberio Brigida , Compostella Federico , Girardin Giulia , D’Incà Renata , Marinelli Carla , Marsilio Ilaria , Lorenzon Greta , Savarino Edoardo Vincenzo 
Published: July 2020

Background: Data on vedolizumab (VDZ) use in inflammatory bowel disease (IBD) patients are still limited. We aimed to assess the effectiveness and tolerability of VDZ in a real-life clinical scenario. Methods: We retrospectively collected data of all consecutive IBD patients who started VDZ from September 2016 to December 2018 at our IBD Unit of the University Hospital of Padua and strictly followed them for 1 year. Clinical benefit (rate of clinical steroid-free remission plus clinical response), endoscopic and histological responses were evaluated over 1 year. Results: A total of 117 patients who started VDZ for Crohn’s disease (CD) and ulcerative colitis (UC) were included in the main analysis (69 CD patients, 48 UC patients). We obtained a clinical benefit in 68.1%, 68.1% and 59.4% of CD patients and in 68.7%, 54.2% and 54.1% of UC patients after induction, and at 30 weeks and 52 weeks, respectively. After 1 year, endoscopy response was observed in 47% of CD and 38.2% of UC patients, while the histological response was 19.6% and 23.5%, respectively. Finally, we found that 20.5% of patients needed treatment optimization, with 33.3% of them failing to respond despite this action. No deaths or serious adverse events requiring hospitalization were observed. The main cause of VDZ interruption was drug inefficacy. During the study, two patients developed new spondylarthritis, and two had a worsening of pre-existing arthralgia. Conclusion: Vedolizumab resulted in being effective and safe in CD as well as in UC patients.
Evaluation of Scientific and Technological Research in China’s Colleges: A Review of Policy Reforms, 2000–2020
Authors: Zhu Junwen 
Published: July 2020

Purpose: This study conducts a systematic review of policy reforms for the evaluation of scientific and technological research (E-STR) in China’s colleges. In doing so, it identifies changes to past policies, as well as the objectives and realizability of the most recent policy reform. Design/Approach/Methods: This study systematically reviews the contexts of E-STR policy reforms in China’s colleges post 2000 using three important related policy documents from 2003, 2013, and 2020 as samples. Research findings were obtained via content analysis. Findings: Unlike previous attempts, the most recent policy reform has incorporated the lessons learned while introducing highly targeted measures and a monitoring mechanism. Such reform should accelerate the promotion of major original scientific research in China’s colleges, enhance the contribution of scientific research to socioeconomic development, and strengthen support for the cultivation of undergraduate talents. Originality/Value: Initiated in the early part of 2000, China’s latest E-STR policy reform constitutes an important turning point in the initiative to burst the research bubble and return to the essence of innovation. It will drive China’s colleges to embark on a research path that places value on original innovation and contribution to socioeconomic development.
Correlations and Reproducibility Between Radiographic and Radial Alpha Angles in the Evaluation of Cam Morphology
Authors: Kobayashi Naomi , Sumi Kosuke , Higashihira Shota , Choe Hyonmin , Tezuka Taro , Oishi Takayuki , Yukizawa Yohei , Morita Akira , Inaba Yutaka 
Published: July 2020

Background: The alpha angle used to evaluate cam morphology can be determined on different imaging views; however, 2-dimensional (2D) imaging can present limitations in terms of the reproducibility of the radial alpha angle. Recent developments in 3-dimensional (3D) high-resolution magnetic resonance imaging (MRI) have allowed detailed evaluations of the radial alpha angle. Purpose: To determine whether there are any correlations or discrepancies between the 2D alpha angle on plain radiography and the maximum radial alpha angle on 3D MRI. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: A total of 42 hips from 39 patients (19 males, 20 females) were analyzed, including 22 hips with femoroacetabular impingement (FAI; mean age, 41 years) and 20 hips with borderline developmental dysplasia of the hip (BDDH; mean age, 43 years). Radial images were reconstructed from 3D multiple echo recombined gradient echo (MERGE) MRI. Differences in the maximum radial alpha angle on MRI between hips with FAI and BDDH were evaluated. Correlations and discrepancies between the maximum radial alpha angle on MRI and alpha angles on the anteroposterior, cross-table lateral, and 45° Dunn views of radiography were also evaluated. Results: The maximum radial alpha angle was significantly higher for hips with FAI than for hips with BDDH. On average, the greatest alpha angle on radial MRI was higher than the alpha angle on each of the 3 radiographic views for both FAI and BDDH. The 45° Dunn view revealed the smallest discrepancy for both FAI ( P = .005) and BDDH ( P = .002). The cross-table lateral view had the highest correlation with the maximum radial alpha angle for BDDH ( P < .001). Conclusion: We reconfirmed the utility of the 45° Dunn view, with it presenting the best reproducibility for the maximum radial alpha angle in the evaluation of cam morphology, while the cross-table lateral view revealed the best correlation with the maximum radial alpha angle, particularly for hips with BDDH.
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism
Authors: Hansen Ellen-Sofie , Hindberg Kristian , Latysheva Nadezhda , Aukrust Pål , Ueland Thor , Hansen John-Bjarne , Brækkan Sigrid K. , Morelli Vânia M. ,   the INVENT Consortium
Published: July 2020

Abstract
Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association using Mendelian randomization (MR). We conducted a population-based nested case-control study comprising 416 VTE patients and 848 age- and sex-matched controls derived from the Tromsø Study. Logistic regression was used to calculate odds ratios (ORs) for VTE across GDF-15 quartiles. For the MR, we used data from the International Network on Venous Thrombosis (INVENT) consortium to examine whether single nucleotide polymorphisms (SNPs) associated with GDF-15 levels with genome-wide significance were related to VTE. We found that the ORs for VTE increased across GDF-15 quartiles (Ptrend = .002). Participants with GDF-15 values in the highest quartile (≥358 pg/mL) had an OR for VTE of 2.05 (95% confidence interval, 1.37-3.08) compared with those with GDF-15 in the lowest quartile (&lt;200 pg/mL) in the age- and sex-adjusted model. ORs remained essentially the same after further adjustment for body mass index, smoking, hormone therapy, physical activity, and C-reactive protein. Similar results were obtained for provoked/unprovoked events, deep vein thrombosis, and pulmonary embolism. GDF-15 levels, as predicted by the SNPs, were not associated with VTE in MR. Our results indicate that high GDF-15 levels are associated with increased risk of VTE, but MR suggests that this association is not causal.
HIV antiretroviral therapy and prevention use in US blood donors: a new blood safety concern
Authors: Custer Brian , Quiner Claire , Haaland Richard , Martin Amy , Stone Mars , Reik Rita , Steele Whitney R. , Kessler Debra , Williamson Phillip C. , Anderson Steven A. , Williams Alan E. , Raymond Henry F. , McFarland Willi , Robinson William T. , Glick Sara , Sey Kwa , Melton C. David , Glynn Simone A. , Stramer Susan L. , Busch Michael P. 
Published: July 2020

Abstract
Antiretroviral therapy (ART) to treat and pre-exposure prophylaxis (PrEP) to prevent HIV infection are effective tools to help end the HIV epidemic. However, their use could affect HIV transfusion-transmission risk. Three different ART/PrEP prevalence analyses in blood donors were conducted. First, blood samples from HIV-positive and a comparison group of infection-nonreactive donors were tested under blind using liquid chromatography-tandem mass spectrometry for ART. Second, blood donor samples from infection-nonreactive, 18- to 45-year-old, male, first-time blood donors in 6 US locations were tested for emtricitabine and tenofovir. Third, in men who have sex with men (MSM) participating in the 2017 Centers for Disease Control and Prevention National HIV Behavioral Surveillance (NHBS) from 5 US cities, self-reported PrEP use proximate to donation was assessed. In blind testing, no ART was detected in 300 infection-nonreactive donor samples, but in 299 HIV confirmed-infected donor samples, 46 (15.4%; 95% confidence interval [CI], 11.5% to 20.0%) had evidence of ART. Of the 1494 samples tested from first-time male donors, 9 (0.6%; 95% CI, 0.03% to 1.1%) had tenofovir and emtricitabine. In the NHBS MSM survey, 27 of 591 respondents (4.8%; 95% CI, 3.2% to 6.9%) reported donating blood in 2016 or 2017 and PrEP use within the same time frame as blood donation. Persons who are HIV positive and taking ART and persons taking PrEP to prevent HIV infection are donating blood. Both situations could lead to increased risk of HIV transfusion transmission if blood screening assays are unable to detect HIV in donations from infected donors.
The outcomes of one-stage treatment for multiple knee ligament injuries combined with extensor apparatus rupture
Authors: Zhao Daohong , Yang Zhongde , Wu Changsha , Zhong Jia , Zhou Xizong , Li Jinghua , Li Yan , Lu Yongsheng , Shen Duo 
Published: July 2020

Abstract
Background
Multiple knee ligament injuries combined with extensor apparatus rupture are serious and complex knee injuries that are rare in clinical practice. The management is extremely challenging and controversial.
The aim of this study is to describe a patient collective with multiple knee ligament injuries combined with extensor apparatus injuries in detail and to report the mid-term outcomes of a one-stage surgical treatment regarding subjective outcome scores, complications, knee instability, and ROM.

Methods
Eleven of 425 patients with multiple knee ligament injuries combined with extensor apparatus injuries admitted to our hospital were reviewed from July 2008 to May 2017. All patients underwent one-stage repair and reconstruction of multiple knee ligaments and extensor apparatus. The Lysholm knee score and the International Knee Documentation Committee (IKDC) score were adopted to evaluate the surgical effect preoperatively and at a minimum of 2 years’ follow-up. Clinical data, including range of motion and knee stability, were also recorded at the final follow-up.

Results
Ten patients were followed up with a mean time of 40 (range, 24–60) months. At the last follow-up, 8 patients had joint flexion range of motion greater than or equal to120 degrees, 2 patients had joint flexion range of motion of 100–120 degrees, and 1 patient had active knee extension limitation of 5 degrees. Stress radiographs showed that the mean differences in posterior displacement were reduced from 10.8 ± 3.0 mm preoperatively to 2.0 ± 2.5 mm at the last follow-up. There were significant improvements in stress radiographs from pre- to postoperative states for all patients with multiple knee ligament injuries. The Lysholm score ranged from 85 to 96, with a mean of 92.1 (compared with 33 before surgery, P < 0.05). The final IKDC scores were A in 2 patients (20%), B in 7 (70%), and C in 1 (10%). Nine of the 10 patients (90%) returned to their former activity level.

Conclusion
Multiple knee ligament injuries combined with extensor apparatus rupture are rare. Single-stage management of the repair and reconstruction of multiple knee ligaments and extensor apparatus with proper rehabilitation is an effective and reliable procedure to restore knee stability and function.

Level of evidence
Level IV, therapeutic case series.
No differences in cost-effectiveness and short-term functional outcomes between cemented and uncemented total knee arthroplasty
Authors: Rassir R. , Nolte P. A. , van der Lugt J. C. T. , Nelissen R. G. H. H. , Sierevelt I. N. , Verra W. C. 
Published: July 2020

Abstract
Background
There is an ongoing debate regarding optimal fixation of total knee arthroplasty (TKA), however cost has not been addressed as profoundly. Therefore, the current study primarily aimed to compare costs and cost-effectiveness 1 year after cemented or uncemented TKA. A secondary objective was to compare short-term functional outcomes between both groups.

Methods
A posthoc prospective observational multicenter cohort study of 60 cemented and 50 uncemented Low Contact Stress (LCS) knee systems. Outcome was evaluated using the EuroQol5D-3 L (EQ5D) index, in order to calculate quality adjusted life years (QALYs). Total costs were calculated considering direct costs within the hospital setting (inpatient cost) as well as direct and indirect costs outside the hospital. Cost-effectiveness (total costs per QALY), Oxford Knee Score (OKS) and Numeric Rating Scale (NRS) were compared between cemented and uncemented cases at 1 year after surgery. HealthBASKET project, a micro-costing approach, represents the Dutch costs and situation and was used to calculate hospital stay. (In) direct costs outside the healthcare (medical cost and productivity cost) were determined using two validated questionnaires.

Results
Median costs per QALY were similar between cemented and uncemented TKA patients (€16,269 and €17,727 respectively; p = 0.50). Median OKS (44 and 42; p = 0.79), EQ5D (0.88 and 0.90; p = 0.82) and NRS for pain (1.0 and 1.0; p = 0.48) and satisfaction (9.0 and 9.0; p = 0.15) were also comparable between both groups.

Conclusion
For this type of knee implant (LCS), inpatient hospital costs and costs after hospitalization were comparable between groups.