bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS MODEL PEMBELAJARAN INKUIRI TERBIMBING TERHADAP KETERAMPILAN PROSES SAINS DAN PEMAHAMAN KONSEP FISIKA SISWA MA RIYADHUS SOLIHIN
Authors: Sulistiyono Sulistiyono 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan model pembelajaran inkuiri terbimbing dalam meningkatkan keterampilan proses sains dan pemahaman konsep fisika. Jenis penelitian yang dunakan dalam penelitian ini adalah quasi-experiment research menggunakan pretest posttest control group design. Popolasi dalam penelitian ini adalah semua siswa kelas X MA Riyadhus Sholihin teknik pengambilan sampel menggunakan cluster random sampling kelas X MIPA 1 sebagai eksperimen dan kelas X MIPA 3 sebagai kelas kontrol. Keterampilan proses sains diukur dengan menggunakan tes esay untuk keterampilan proses sains intelektual dan observasi untuk mengukur keterampilan proses sains manual. Pemahaman konsep fisika siswa diukur dengan menggunakan tes objekti. Data hasil penelitian dianalisis dengan menggunakan Uji MANOVA dan korelari Pearson. Pemahaman konsep fisika siswa diukur dengan menggunakan soal tes. Berdasarkan hasil penelitian menunjukkan bahwa model pembelajaran inkuiri terbimbing efektif untuk meningkatkan keterampilan proses sains dan pemahaman konsep fisika siswa di kelas X MA Riyadhus Sholihin pada materi Suhu dan kalor.
V.V. Rozanov Among Parties and Politicians
Authors: Lomonosov Aleksey V.  
Published: November 2020

The article reveals the social significance of determining the political views of V.V. Rozanov in the system of the thinker’s worldview. The correlation of these views with his political journalism is shown. The genesis of social and political ideas of V.V. Rozanov is revealed. The author specifies his ideological predecessors in the sphere of public thought of the late 19th century and the thinker’s affiliation with the conservative political camp of Russian writers. The author of the article also gives coverage of the V.V. Rozanov’s polemical publications in the press. He outlines the circle of political sympathies and determinative constants in the political views of Rozanov-publicist and proves his commitment to the centrist political parties. The author examines the process of Rozanov’s socio-political views evolution at the turn of the 19th–20th centuries, and the related changes in his political journalism. The evaluations are based on the large layer of Rozanov’s newspaper publicism in the years of 1905–1917. To determine the Rozanov’s position in the “New time” journal editorial office and to reveal the motives of his political essays the author of the article used epistola
A Little-Known Side of I.A. Ilyin’s Work “On Resistance to Evil by Force”
Authors: Vakulinskaya Alexandra I. 
Published: November 2020

The article touches upon an interesting fact from the biography of I.A. lyin, which is connected with the drafting of the book “On resistance to evil by force”, and, specifically, his work on Jesuitical theological literature. Within the publication, a section is set forth which was not included in Chapter 20 of the book and which has been kept in the archive of the philosopher until present. A few analytical comments are set forth regarding the contents of the text.
A Clinical Case of Stomach Perforation Concealed by a Foreign Body
Authors: Garaev M. R. , Vorotnikov M. Yu. , Garayeva Z. R. , Nartaylakov M. A. 
Published: November 2020

Introduction. Stomach perforations caused by ingested foreign bodies are extremely rare injuries in adults, accounting for less than 1% of all gastrointestinal perforations. The clinical picture is diverse and often presents a diagnostic problem. There are few publications reporting such cases in literature.Materials and methods. Using the example of a clinical case, this paper describes the clinical picture, diagnostic role of X-ray instruments and surgical tactics of diagnosing and treating a stomach perforation concealed by a foreign object, which occurred one week prior to admission. The patient V., 52 yo, was admitted to hospital on an emergency basis in the condition of moderate severity, complaining of abdominal pain for two days. The onset of the disease had no apparent reason. Similar pains had bothered the patient a week earlier the incident but were relieved without treatment.Results and discussion. On the basis of clinical and laboratory-instrumental data, acute pancreatitis was pre-diagnosed. Conservative drug therapy with positive dynamics was started. Two days later, computed tomography of the abdominal organs with intravenous bolus contrast was performed. According to the CT data, a foreign body in the abdominal cavity was identified, which rested on the liver at the level of the gallbladder, perforating the wall of the pyloric department of the stomach. Localized inflammatory effusion in the abdominal fat was observed. The patient was operated and discharged in satisfactory condition.Conclusion. Stomach perforations caused by small-sized foreign bodies are characterized by non-specific clinical manifestations. The use of radiation diagnostic methods facilitates the timely diagnosis and therapy choice in patients with stomach perforations caused by small-sized foreign bodies.
Software de diseño de instrucción. Evaluación de su utilidad para diseñar exposiciones educativas en museos.
Authors: Bosch Bonacasa Josep 
Published: November 2020

Algunas exposiciones museísticas se diseñan con objetivos educativos; estas exposiciones, se enmarcan dentro de la educación no formal aunque, si se analizan desde el punto de vista de la instrucción, tienen muchos aspectos en común con las actividades educativas de la educación formal.
Existe software desarrollado para diseñar actividades propias de la educación formal; en cambio, no se ha encontrado software para el diseño de exposiciones educativas en museos.
El objetivo de esta investigación es responder dos preguntas:
1. ¿Puede algún software existente ser utilizado para diseñar exposiciones educativas en museos?
2. ¿Puede algún software existente servir de base para desarrollar un software específico para diseñar exposiciones educativas en museos?
Para responder estas preguntas, en primer lugar, se han seleccionado y definido los conceptos que debería incluir un software para el diseño de exposiciones; muchos de estos conceptos son compartidos con los utilizados para el diseño de las actividades propias de la educación formal; otros, son específicos y han sido definidos en esta investigación.
En segundo lugar, de entre diecisiete software de diseño de instrucción, se han seleccionado cinco que han podido ser instalados y evaluados. A continuación se ha verificado, uno a uno, si contemplan los conceptos que un software de diseño de exposiciones debería incluir.
Los resultados de la evaluación se presentan en forma de tabla y algunas observaciones; su análisis ha permitido responder las preguntas formuladas.
De los cinco evaluados, uno, Compendium LD, puede ser utilizado para el diseño de exposiciones educativas en museos aunque, con limitaciones. Ninguno de los analizados contempla conceptos importantes como la ubicación de los objetos educativos en el espacio o la descripción de los recorridos del visitante. Compendium LD puede ser, además, un buen punto de partida para desarrollar un software específico.
Comparison of the biomechanical performance of a customized unilateral locking compression plate with and without an intervertebral spacer applied to the first and second lumbar vertebrae after intervertebral diskectomy in canine cadaveric specimens
Authors: Selz Julie , Voumard Benjamin , Forterre Franck 
Published: November 2020

Abstract

OBJECTIVE
To determine whether a customized unilateral intervertebral anchored fusion device combined with (vs without) an intervertebral spacer would increase the stability of the L1-L2 motion segment following complete intervertebral diskectomy in canine cadaveric specimens.

SAMPLE
Vertebral columns from T13 through L3 harvested from 16 skeletally mature Beagles without thoracolumbar disease.

PROCEDURES
Complete diskectomy of the L1-2 disk was performed in each specimen. Unilateral stabilization of the L1-L2 motion segment was performed with the first of 2 implants: a unilateral intervertebral anchored fusion device that consisted of a locking compression plate with or without an intervertebral spacer. The resulting construct was biomechanically tested; then, the first implant was removed, and the second implant was applied to the contralateral side and tested. Range of motion in flexion and extension, lateral bending, and torsion was compared among intact specimens (prior to diskectomy) and constructs.

RESULTS
Compared with intact specimens, constructs stabilized with either implant were as stable in flexion and extension, significantly more stable in lateral bending, and significantly less stable in axial rotation. Constructs stabilized with the fusion device plus intervertebral spacer were significantly stiffer in lateral bending than those stabilized with the fusion device alone. No significant differences in flexion and extension and rotation were noted between implants.

CONCLUSIONS AND CLINICAL RELEVANCE
Findings did not support the use of this customized unilateral intervertebral anchored fusion device with an intervertebral spacer to improve unilateral stabilization of the L1-L2 motion segment after complete L1-2 diskectomy in dogs.
Effects of kernel and window setting combinations on assessments of small and complicated vasculature in computed tomography angiographic images of dogs with and without tumors
Authors: Yoon Sooa A. , Park Seungjo J. , Choi Jihye H. 
Published: November 2020

Abstract

OBJECTIVE
To evaluate the effect of kernel and window settings on the assessment of small and complicated vasculature in CT angiographic (CTA) images of kidneys, jejunum with mesentery, and tumors in dogs.

ANIMALS
20 healthy dogs and 20 dogs with tumors.

PROCEDURES
Images from CTA performed previously in dogs were reconstructed with 3 different combinations of kernel and window settings (soft kernel with soft tissue window, soft kernel with bone window, and sharp kernel with bone window), and reconstructed images of the left kidney and the jejunum with the mesentery in healthy dogs and tumors in affected dogs were evaluated by reviewers blinded to the settings.

RESULTS
For images of kidney and jejunum with mesentery, reviewers’ scores for the conspicuity of vascularity in the arterial phase and the differentiation of the organs from the adjacent structures were significantly higher when viewed in bone window (vs soft tissue window) regardless of kernel setting. For images of head and gastrointestinal tumors, reviewers’ scores for differentiation of intratumoral vasculature were higher when viewed in sharp kernel with bone window versus other setting combinations. However, the conspicuity of gastrointestinal, hepatic, or splenic tumoral vessels from the adjacent structures had higher reviewer scores for images in soft kernel with soft tissue window, compared with other setting combinations.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that reconstruction of CTA images with sharp kernel combined with bone window settings might have clinical utility in evaluating and planning treatments for dogs with various tumors; however, additional research is warranted to further identify effects of various kernel and window setting combinations on assessments of small and complicated vasculature in larger and more diverse populations of dogs with and without tumors.
Bio-Fuel Properties and Elemental Analysis of Bio-Oil Produced from Pyrolysis of Gmelina Arborea
Authors: Adegoke Idowu A , Ogunsanwo O.Y , Ige Ayodeji R. 
Published: November 2020

Abstract
Nigeria demand for sustainable, affordable and accessible energy is on the rise. Hence, this led to rigorous research to determine affordable processes of using waste materials for production of sustainable energy. In this research pyrolysis was carried out in a fabricated fixed bed pilot-scale reactor using Gmelina arborea (sawdust) biomass for the production of bio-oil. The physical, chemical properties and the ultimate analysis of the bio oil produced were determined following standard methods. The physicochemical properties and ultimate analysis obtained were favourable. The highest moisture content of 21 % at 600 °C and least moisture content of 12 % at 900 °C were obtained from Gmelina arborea. The elemental results of the products show low sulphur quantity which is of good prospects that Gmelina arborea are good materials for bioenergy production without posing danger to the environment. Utilisation of Gmelina arborea for bio-oil production as an alternative fuel would shun unfavourable environmental abasement related to the use of conventional fuels.
Effects of Quarantine Due to the COVID-19 on Sleep Duration and Quality in Algerians
Authors: Abdelhadi Kacem , Abdelatif Houar , Mohamed Zerf , Ali Bengoua 
Published: November 2020

Summary
This study tests the impact of COVID-19 on sleep of Algerian population before and during the COVID-19 quarantine by an estimated online survey, adapted from the PSQI Italian version. Including 1210 participants (age between 18-60 years old). The statistical analysis was carried out using SPSS version 22.0 software. Our results showed a significant change in sleeping quality during quarantine, the sleep timing markedly changed, we also noticed additional use of sleeping medications. Algerian scientists recommend to build public awareness and to provide necessary information regarding Algerian sleep quality, especially for Algerian adults.
Comparison of Two Tests to Determine the Maximal Aerobic Speed
Authors: Saddek Benhammou , Coquart Jérémy B.J. , Mourot Laurent , Adel Belkadi , Idriss Mokkedes Moulay , Ali Bengoua , Djamel Mokrani 
Published: November 2020

Summary
The aims of this study were (a): to compare maximal physiological responses (maximal heart rate: HRmax and blood lactate concentration: [La-]) and maximal aerobic speed (MAS) achieved during a gold standard test (T-VAM) to those during a new test entitled: the 150-50 Intermittent Test (150-50IT), and (b): to test the reliability of the 150-50IT. Eighteen middle-distance runners performed, in a random order, the T-VAM and the 150-50IT. Moreover, the runners performed a second 150-50IT (retest). The results of this study showed that the MAS obtained during 150-50IT were significantly higher than the MAS during the T-VAM (19.1 ± 0.9 vs. 17.9 ± 0.9 km.h−1, p < 0.001). There was also significant higher values in HRmax (193 ± 4 vs. 191 ± 2 bpm, p = 0.011), [La-] (11.4 ± 0.4 vs. 11.0 ± 0.5 mmol.L−1, p = 0.039) during the 150-50IT. Nevertheless, significant correlations were noted for MAS (r = 0.71, p = 0.001) and HRmax (r = 0.63, p = 0.007). MAS obtained during the first 150-50IT and the retest were not significantly different (p = 0.76) and were significantly correlated (r = 0.94, p < 0.001, intraclass correlation coefficient = 0.93 and coefficient of variation = 6.8 %). In conclusion, the 150-50IT is highly reproducible, but the maximal physiological responses derived from both tests cannot be interchangeable in the design of training programs.
Screening of Pathophysiological Mechanisms and Psychological and Occupational Factors, Determining Risk of Cardiovascular Diseases in High-Risk Professions
Authors: Nikolova R. , Danev S. , Kundurjiev T. , Madjarov N. 
Published: November 2020

Abstract
Cardiovascular diseases (CVD) are among the most significant and common chronic non-communicable diseases in Bulgaria. Screening, identification and registration of pathophysiological mechanisms and psychological and occupational factors related to CVD should be implemented in the diagnostic work-up. Job analysis contributes to the implementation of screening and identification of the most significant psychological and professional factors related to the work activity.

Aim: The aim of our study is to examine the pathophysiological mechanisms of autonomic cardiovascular control and psychological and occupational factors determining the risk of CVD.

Materials and methods: The following groups of individuals were examined: 83 physicians, 54 nurses, 23 employees and 40 militaries. The autonomic cardiovascular control was studied through the time-and frequency-domain based measures of the Analysis of Heart Rate Variability (HRV).

Results: The results of the ANOVA test showed that there was a statistically significant difference in the time-domain and frequency-domain based HRV measures between the compared groups: X [F (4; 225) = 4.455, p = 0.001]; SDNN [F (4; 225) = 3.876, p = 0.005]; SDNN5 [F (4; 225) = 3.083, p = 0.01]; pNN50 [F (4; 225) = 8.303, p < 0.001]; rMSSD [F (4; 225) = 8.711, p < 0.001]; SDSD [F (4; 225) = 8.323, p < 0.001; VLF [F (4; 225) = 1.204, p = 0.31]; LF [F (4; 225) = 3.874, p = 0.005]; HF [F (4; 225) = 7.790, p < 0.001] and LF/HF [F (4; 225) = 8.601, p < 0.001]. The results of our study revealed that occupational stress and cognitive workload in physicians, nurses, and employees induced a process of reciprocally combined inhibition of the parasympathetic branch of the autonomic nervous system (ANS) (SDNN, SDNN5, pNN50, rMSSD, and HF) and activation of the sympathetic branch of ANS (LF), while in military personnel they cause a process of co-activation of the parasympathetic and sympathetic branches of the ANS (rMSSD, SDNN, SDNN5, pNN50 and LF/HF).

Conclusion: Stress-induced dysfunctional autonomic cardiovascular regulation, patho-physiological control mechanisms, psychological and occupational factors determine the risk of CVD. Their identification could contribute to the diagnostics and prevention of CVD.
Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
Authors: Krasteva M. , Koycheva Y. , Taseva T. , Simeonova S. 
Published: November 2020

Abstract

Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this study we analyzed the expression levels of genes involved in DNA methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 and MBD4, in blood samples of alcohol and drug dependent persons in comparison to healthy abstainers.

Methods. The study included 51 participants: 16 persons with alcohol dependence, 17 persons with drug dependence and 18 clinically healthy controls. To detect the relative mRNA expression levels of the studied genes, Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis was applied.

Results. Of the seven studied genes, four showed altered expression. MeCP2 and MBD1 were downregulated in the alcohol dependent group (FC = 0.805, p = 0.015 and FC = 0.846, p = 0.034, respectively), while DNMT1 and MBD4 were upregulated in the group with drug dependence (FC = 1.262, p = 0.001 and FC = 1.249, p = 0.005, respectively). No statistically significant changes in the relative mRNA expression were found for DNMT3a, MBD2 and MBD3 genes.

Conclusions. Our results are indicative for a role of DNA methylation related genes in alcohol and drug addiction mediated through changes in their transcriptional activity. Studies in this direction will enable better understanding of the underlying mechanisms of addictions supporting the development of more effective therapeutic strategies.
Outcome After Azacitidine Treatment in Patients with High-Risk Myeolodysplastic Syndrome, Chronic Myelomonocytic Leukemia Type 2 and Acute Myeloid Leukemia – A Single Center Experience (Preliminary Data)
Authors: Varbanova V. , Anastasova-Postadzhiyan A. , Nedeva A. , Nikolov I. , Kindekov I. , Kuyumdzhieva Y. , Petkova N. , Vikentieva E. , Lubomir M. , Raynov J. 
Published: November 2020

Abstract

Introduction: Hypomethylating agents have become a standard therapy for certain myeloid malignancies.

Aim: The aim of this preliminary study was to assess efficacy and safety of azacitidine in patients with myelodysplas tic syndromes (MDS), chronic myelomonocytic leukemia with 10-29% blasts (CMML-2) and acute myeloid leukemia (AML) treated in a single center.

Material and Methods: Twenty-six (69% male and 31% female, median age 67.8 years) patients (MDS, = 15; CMML-2, n = 2; AML, n = 9) treated with azacytidine in the period April 2017 to October 2018 year were included in the study. Disease assessment was performed after the 3rd cycle, 6th cycle, and at progression.

Results: The median number of administered cycles was 6 (1-16). Erythroid response was achieved in 46.7% after 3rd cycle and 66.7% after 6th cycle. Platelet response was reached in 72.7% after 3rd cycle and 40% after 6th cycle and neutrophil hematological improvement in 27.3% and 50%, respectively. Only one patient (8.3%) progressed after the 6th cycle, stable disease or better marrow response was achieved in the others. The median progression free survival (PFS) and overall survival (OS) were 7.9 and 10.7 months in the MDS group and 9.7 and 11.5 months in the AML group, respectively. None of the patients with CMML-2 progressed at the end of the study. The only found factor to correlate with shortened PFS and OS was IPSS high risk MDS. The most frequent grade ≥ 3 adverse events was neutropenia 38.5%, followed by anemia 15.4% and thrombocytopenia 11.5%.

Conclusion: The therapy with azacitidine is an option for elderly patients with high-risk MDS, AML and CMML-2 that provides PFS and OS for approximately one year irrespective of age or nosological subgroup. These are preliminary data and larger patient cohort and longer follow-up period are needed for clinical conclusions.
Changes in Bone Metabolism and Structure in Primary Hyperparathyroidism
Authors: Yankova I. , Shinkov A. , Kovatcheva R. 
Published: November 2020

Abstract
Parathyroid hormone (PTH) is a key regulator of bone turnover. Depending on the duration of action, the hormone causes catabolic and anabolic effects by binding with specific receptors (PTHR1) in the bone. Various cells expressing PTHR1 on their surface are involved in the process – osteoblasts, osteocytes, bone marrow stromal cells, T-lymphocytes and macrophages. In physiological conditions PTH balances the bone metabolism. Intermittent pharmacological doses of PTH lead to the prevalence of bone formation and are used in the treatment of osteoporosis. Persistently elevated levels of PTH stimulate bone resorption by impacting mainly the cortical bone. New imaging and analysis techniques show that high PTH levels can also have an adverse effect on trabecular microarchitecture. Primary hyperparathyroidism (PHPT) is a disease characterized by increased bone metabolism, decreased bone mineral density (BMD), inadequate osteoid mineralization and an increased risk of fractures. Prolonged overproduction of PTH leads to stimulation of bone resorption and defects in bone formation, mainly causing loss of cortical bone mass, while in the trabecular bone predominate demineralization processes. One explanation of these findings is the enhanced stimulation of RANKL expression by osteoblasts with decreased OPG expression and bone formation at the same time.