bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis
Authors: Mulholland Bridie S. , Forwood Mark R. , Morrison Nigel A. 
Published: November 2019

Abstract

Purpose of Review
The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone.

Recent Findings
MCP-1 is a key mediator of osteoclastogenesis, being the highest induced gene during intermittent treatment with parathyroid hormone (iPTH), but also regulates catabolic effects of continuous PTH on bone including monocyte and macrophage recruitment, osteoclast formation and bone resorption. In concert with PTH-related protein (PTHrP), MCP-1 mediates the interaction between tumour-derived factors and host-derived chemokines to promote skeletal metastasis. In breast and prostate cancers, an osteolytic cascade is driven by tumour cell–derived PTHrP that upregulates MCP-1 in osteoblastic cells. This relationship between PTHrP and osteoblastic expression of MCP-1 may drive the colonisation of disseminated breast cancer cells in the bone.

Summary
There is mounting evidence to suggest a pivotal role of MCP-1 in many diseases and an important role in the establishment of comorbidities. Coupled with its role in bone remodelling and the regulation of bone turnover, there is the potential for pathological relationships between bone disorders and bone-related cancers driven by MCP-1. MCP-1’s role in bone remodelling and bone-related cancers highlights its potential as a novel anti-resorptive and anti-metastatic target.
Land Cover/Land Use Mapping of LISS IV Imagery Using Object-Based Convolutional Neural Network with Deep Features
Authors: Rajesh S. , Nisia T. Gladima , Arivazhagan S. , Abisekaraj R. 
Published: November 2019

Abstract
The paper proposes a new method for classifying the LISS IV satellite images using deep learning method. Deep learning method is to automatically extract many features without any human intervention. The classification accuracy through deep learning is still improved by including object-based segmentation. The object-based deep feature learning method using CNN is used to accurately classify the remotely sensed images. The method is designed with the technique of extracting the deep features and using it for object-based classification. The proposed system extracts deep features using pre-defined filter values, thus increasing the overall performance of the process compared to randomly initialized filter values. The object-based classification method can preserve edge information in complex satellite images. To improve the classification accuracy and to reduce complexity, object-based deep learning technique is used. The proposed object-based deep learning approach is used to drastically increase the classification accuracy. Here, the remotely sensed images were used to classify the urban areas of Ahmadabad and Madurai cities. Experimental results show a better performance with the object-based classification.
Freshwater Sordariomycetes
Authors: Luo Zong-Long , Hyde Kevin D. , Liu Jian-Kui (Jack) , Maharachchikumbura Sajeewa S. N. , Jeewon Rajesh , Bao Dan-Feng , Bhat Darbhe Jayarama , Lin Chuan-Gen , Li Wen-Li , Yang Jing , Liu Ning-Guo , Lu Yong-Zhong , Jayawardena Ruvishika S. , Li Jun-Fu , Su Hong-Yan 
Published: November 2019

AbstractSordariomycetes is one of the largest classes of Ascomycota that comprises a highly diverse range of fungi mainly characterized by perithecial ascomata and inoperculate unitunicate asci. Freshwater Sordariomycetes play an important role in ecosystems and some of them have the potential to produce bioactive compounds. This study documents and reviews the freshwater Sordariomycetes, which is one of the largest and important groups of fungi in aquatic habitats. Based on evidence from DNA sequence data and morphology, we introduce a new order Distoseptisporales, two new families, viz. Ceratosphaeriaceae and Triadelphiaceae, three new genera, viz.Aquafiliformis,DematiosporiumandNeospadicoides, 47 new species, viz.Acrodictys fluminicola,Aquafiliformis lignicola,Aquapteridospora fusiformis,Arthrinium aquaticum,Ascosacculus fusiformis,Atractospora aquatica,Barbatosphaeria lignicola,Ceratosphaeria aquatica,C. lignicola,Chaetosphaeria aquatica,Ch. catenulata,Ch. guttulata,Ch. submersa,Codinaea yunnanensis,Conioscypha aquatica,C. submersa,Cordana aquatica,C. lignicola,Cosmospora aquatica,Cylindrotrichum submersum,Dematiosporium aquaticum,Dictyochaeta cangshanensis,D. ellipsoidea,D. lignicola,D. submersa,Distoseptispora appendiculata,D. lignicola,D. neorostrata,D. obclavata,Hypoxylon lignicola,Lepteutypa aquatica,Myrmecridium aquaticum,Neospadicoides aquatica,N. lignicola,N. yunnanensis,Ophioceras submersum,Peroneutypa lignicola,Phaeoisaria filiformis,Pseudostanjehughesia lignicola,Rhodoveronaea aquatica,Seiridium aquaticum,Sporidesmiella aquatica,Sporidesmium lageniforme,S. lignicola,Tainosphaeria lunata,T. obclavata,Wongia aquatica, two new combinations, viz.Acrodictys aquatica,Cylindrotrichum aquaticum, and 9 new records, viz.Chaetomium globosum,Chaetosphaeria cubensis,Ch. myriocarpa,Cordana abramovii,Co. terrestris,Cuspidatispora xiphiago,Sporidesmiella hyalosperma,Stachybotrys chartarum,S. chlorohalonata. A comprehensive classification of the freshwater Sordariomycetes is presented based on updated literature. Phylogenetic inferences based on DNA sequence analyses of a combined LSU, SSU, RPB2 and TEF1α dataset comprising species of freshwater Sordariomycetes are provided. Detailed information including their habitats distribution, diversity, holotype, specimens collected and classification are provided.
Contribution of the Rise in Cohabiting Parenthood to Family Instability: Cohort Change in Italy, Great Britain, and Scandinavia
Authors: Thomson Elizabeth , Winkler-Dworak Maria , Beaujouan Éva 
Published: November 2019

Abstract
In this study, we investigate through microsimulation the link between cohabiting parenthood and family instability. We identify mechanisms through which increases in cohabiting parenthood may contribute to overall increases in separation among parents, linking micro-level processes to macro-level outcomes. Analyses are based on representative surveys in Italy, Great Britain, and Scandinavia (represented by Norway and Sweden), with full histories of women’s unions and births. We first generate parameters for the risk of first and higher-order birth and union events by woman’s birth cohort and country. The estimated parameters are used to generate country- and cohort-specific populations of women with stochastically predicted family life courses. We use the hypothetical populations to decompose changes in the percentage of mothers who separate/divorce across maternal birth cohorts (1940s to 1950s, 1950s to 1960s, 1960s to 1970s), identifying how much of the change can be attributed to shifts in union status at first birth and how much is due to change in separation rates for each union type. We find that when cohabiting births were uncommon, increases in parents’ separation were driven primarily by increases in divorce among married parents. When cohabiting parenthood became more visible, it also became a larger component, but continued increases in parents’ divorce also contributed to increasing parental separation. When cohabiting births became quite common, the higher separation rates of cohabiting parents began to play a greater role than married parents’ divorce. When most couples had their first birth in cohabitation, those having children in marriage were increasingly selected from the most stable relationships, and their decreasing divorce rates offset the fact that increasing proportions of children were born in somewhat less stable cohabiting unions.
Gradual Change, Homeostasis, and Punctuated Equilibrium: Reconsidering Patterns of Health in Later Life
Authors: Engelman Michal , Jackson Heide 
Published: November 2019

Abstract
Longitudinal methods aggregate individual health histories to produce inferences about aging populations, but to what extent do these summaries reflect the experiences of older adults? We describe the assumption of gradual change built into several influential statistical models and draw on widely used, nationally representative survey data to empirically compare the conclusions drawn from mixed-regression methods (growth curve models and latent class growth analysis) designed to capture trajectories with key descriptive statistics and methods (multistate life tables and sequence analysis) that depict discrete states and transitions. We show that individual-level data record stasis irregularly punctuated by relatively sudden change in health status or mortality. Although change is prevalent in the sample, for individuals it occurs rarely, at irregular times and intervals, and in a nonlinear and multidirectional fashion. We conclude by discussing the implications of this punctuated equilibrium pattern for understanding health changes in individuals and the dynamics of inequality in aging populations.
How Harmful Is Particulate Matter Emitted from Biomass Burning? A Thailand Perspective
Authors: Johnston Helinor J. , Mueller William , Steinle Susanne , Vardoulakis Sotiris , Tantrakarnapa Kraichat , Loh Miranda , Cherrie John W. 
Published: November 2019

Abstract

Purpose of Review
A large body of epidemiological evidence demonstrates that exposure to particulate matter (PM) is associated with increased morbidity and mortality. Many epidemiology studies have investigated the health effects of PM in Europe and North America and focussed on traffic derived PM. However, elevated levels of PM are a global problem and the impacts of other sources of PM on health should be assessed. Biomass burning can increase PM levels in urban and rural indoor and outdoor environments in developed and developing countries. We aim to identify whether the health effects of traffic and biomass burning derived PM are similar by performing a narrative literature review. We focus on Thailand as haze episodes from agricultural biomass burning can substantially increase PM levels.

Recent Findings
Existing epidemiology, in vitro and in vivo studies suggest that biomass burning derived PM elicits toxicity via stimulation of oxidative stress, inflammation and genotoxicity. Thus, it is likely to cause similar adverse health outcomes to traffic PM, which causes toxicity via similar mechanisms. However, there is conflicting evidence regarding whether traffic or biomass burning derived PM is most hazardous. Also, there is evidence that PM released from different biomass sources varies in its toxic potency.

Summary
We recommend that epidemiology studies are performed in Thailand to better understand the impacts of PM emitted from specific biomass sources (e.g. agricultural burning). Further, experimental studies should assess the toxicity of PM emitted from more diverse biomass sources. This will fill knowledge gaps and inform evidence-based interventions that protect human health.
Which Category Is Better: Benchmarking Relational and Graph Database Management Systems
Authors: Cheng Yijian , Ding Pengjie , Wang Tongtong , Lu Wei , Du Xiaoyong 
Published: November 2019

Abstract
Over decades, relational database management systems (RDBMSs) have been the first choice to manage data. Recently, due to the variety properties of big data, graph database management systems (GDBMSs) have emerged as an important complement to RDBMSs. As pointed out in the existing literature, both RDBMSs and GDBMSs are capable of managing graph data and relational data; however, the boundaries of them still remain unclear. For this reason, in this paper, we first extend a unified benchmark for RDBMSs and GDBMSs over the same datasets using the same query workload under the same metrics. We then conduct extensive experiments to evaluate them and make the following findings: (1) RDBMSs outperform GDMBSs by a substantial margin under the workloads which mainly consist of group by, sort, and aggregation operations, and their combinations; (2) GDMBSs show their superiority under the workloads that mainly consist of multi-table join, pattern match, path identification, and their combinations.
In Situ Measurement of Spindle Radial and Tilt Error Motions by Complementary Multi-probe Method
Authors: Ding Fei , Luo Xichun , Chang Wenlong , Wang Zhengjian 
Published: November 2019

Abstract
This paper presents a complementary multi-probe method for measurement of radial and tilt error motions of a spindle. Neither indexing of artefact nor rotating of spindle housing is required and thus make it suitable for in situ evaluation of spindle performance effectively. In order to minimize the harmonic suppression problems commonly encountered in the multi-probe measurement approach, three sets of probe angle combinations were optimized and the harmonics of the three measurements were extracted and composed to reveal the true artefact errors in a complementary way. The exact probe angles were identified by the correlation function of the probe signals after the sensors are mounted onto the fixture and the requirement of high-precision fixtures was alleviated. The evaluation of measurement results showed that the erroneous harmonics were greatly reduced by 70%. Using this method, the radial error motions of the precision air bearing spindle were measured at seven axial positions and then the synchronized tilts error motions were calculated. This demonstrated an effective approach for measuring four degree-of-freedom error motions in one setup with a small number of displacement sensor probes.
Flight performance monitoring with optimal filtering applications
Authors: Deo V. A. , Silvestre F. , Morales M. 
Published: November 2019

ABSTRACTThis work presents an alternative methodology for monitoring flight performance during airline operations using the available inboard instrumentation system. This method tries to reduce the disadvantages of the traditional specific range monitoring technique where instrumentation noise and cruise stabilisation conditions affect the quality of the performance monitoring results. The proposed method consists of using an unscented Kalman filter for aircraft performance identification using Newton’s flight dynamic equations in the body X, Y and Z axis. The use of the filtering technique reduces the effect of instrumentation and process noise, enhancing the reliability of the performance results. Besides the better quality of the monitoring process, using the proposed technique, additional results that are not possible to predict with the specific range method are identified during the filtering process. An example of these possible filtered results that show the advantages of this proposed methodology are the aircraft fuel flow offsets, as predicted in the specific range method, but also other important aircraft performance parameters as the aircraft lift and drag coefficients (CL and CD), sideslip angle (β) and wind speeds, giving the operator a deeper understanding of its aircraft operational status and the possibility to link the operational monitoring results to aircraft maintenance scheduling. This work brings a cruise stabilisation example where the selected performance monitoring parameters such as fuel flow factors, lift and drag bias, winds and sideslip angle are identified using only the inboard instrumentation such as the GPS/inertial sensors, a calibrated anemometric system and the angle-of-attack vanes relating each flight condition to a specific aircraft performance monitoring result. The results show that the proposed method captures the performance parameters by the use of the Kalman filter without the need of a strict stabilisation phase as it is recommended in the traditional specific range method, giving operators better flexibility when analysing and monitoring fleet performance.
Judicial Independence in Dominant Party States: Singapore's Possibilities for China
Authors: ANG Lance , WANG Jiangyu 
Published: November 2019

AbstractCourts in China are often criticized for lacking ‘independence’ from the Chinese party-state. Entrenched perceptions of interference in the judiciary by the political branches of government have continued to fuel public resentment in recent years, risking the legitimacy of the party-state. Such criticisms, however, often fail to appreciate the complex political reality in China and the evolving role of Chinese courts following China's incremental legal reforms since the reform era. What does ‘judicial independence’ mean in the context of a socialist rule of law state such as China? More importantly, can we identify the touchstone of ‘independence’ that should be intrinsic in any judicial institution? In recognition of the resilience of the Chinese party-state in the foreseeable future, the authors contend that widening the scope of judicial independence, as conceptualized herein, in line with China's ongoing judicial reforms provides a better tool for promoting economic development and good governance and enhancing the state's legitimacy in a dominant party state. In this regard, insights are drawn from Singapore, which presents two broad lessons for China: first, a rule of law framework can be established in which the state in a non-Western liberal democracy respects the autonomy of the courts and the judiciary strictly enforces the law enacted by the state within its institutional limits; second, judicial pragmatism in the exercise of judicial power enables the courts to ensure that governmental power is exercised in accordance with the principle of legality, which ensures good governance in a polity governed by a strong state. Contrary to claims that such reforms may serve as an apology for power in China, it is hoped that such reforms may lay the foundation for normative constitutionalism in the future.
Boundary layers in Helmholtz flows
Authors: Moore Madeleine Rose , Cimpeanu R. , Ockendon H. , Ockendon J. R. , Oliver J. M. 
Published: November 2019

Recent comparisons between classical Wagner theory for the impact of two liquid droplets and direct numerical simulations in Cimpeanu & Moore (J. Fluid Mech., vol. 856, 2018, pp. 764–796) show that, in some regimes, the inviscid theory over-predicts the thickness of the root of the splash jet that forms in the impact, while also struggling to predict the angle at which the jet is emitted. The effect of capillary and viscous perturbations to Helmholtz flows was investigated in a previous study, see Moore et al. (J. Fluid Mech., vol. 742, 2014, R1). However, the paper in question ignored a term in the second-order perturbation analysis, which needs to be included in order to predict the displacement of the inviscid free boundary to lowest order. In this paper, we derive a singular integro-differential equation for the free-surface perturbations caused by viscosity in Helmholtz flows and discuss its application both in the context of Wagner theory and more generally. In particular, viscosity can induce non-monotonic behaviour in the free boundary profiles near points of maximum curvature.
Human immunodeficiency disease in new diagnoses of head and neck squamous cell cancer: are we testing?
Authors: McNamara K J , Fernandez C , Saunders T F C , Ahsan F 
Published: November 2019

AbstractBackgroundHuman immunodeficiency virus infected patients have a three-fold increased risk of head and neck squamous cell carcinoma. The British HIV Association recommends human immunodeficiency virus testing in all new diagnoses of head and neck squamous cell carcinoma.ObjectivesThis observational study aimed to examine the current routine practice of human immunodeficiency virus testing in patients with newly diagnosed head and neck squamous cell carcinoma, and to address the importance of this test in promoting the early diagnosis and treatment of human immunodeficiency virus.MethodsAll head and neck cancer multidisciplinary teams in England were questioned on their protocol for human immunodeficiency virus testing in new diagnoses of head and neck squamous cell carcinoma.ResultsOnly 1 out of 30 hospitals leading head and neck multidisciplinary teams (3.3 per cent) routinely offered human immunodeficiency virus testing in this high-risk patient group.ConclusionThis observational study highlights that head and neck specialists are not aware of, and are consequently not complying with, routine human immunodeficiency virus testing as recommended by the British HIV Association guidelines.
Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma
Authors: Hamdan A-L , Khalifee E , Jaffal H , Ghanem A 
Published: November 2019

AbstractObjectivesTo report on the efficacy and adverse effects of interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma.MethodsA retrospective chart review was conducted of eight patients with vocal process granuloma resistant to anti-reflux therapy who underwent interarytenoid botulinum toxin A injection. The mean dosage of botulinum toxin A injected was 6.56 U.ResultsFifty per cent of patients had complete regression of the lesion and 50 per cent had partial regression. The main side effects were breathiness (n = 4), voice breaks (n = 1) and aspiration (n = 1).ConclusionInterarytenoid botulinum toxin A injection for the treatment of vocal process granuloma is an effective mode of therapy, with transient vocal and swallowing side effects.
Améliorer le rappel des individus âgés de 60 ans et plus à l’aide de l’entretien cognitif : une revue et méta-analyse
Authors: Hurtubise Marc-Antoine , Viau-Quesnel Charles 
Published: November 2019

RÉSUMÉLes aînés sont souvent perçus comme des témoins peu fiables, une perception qui est partiellement appuyée par des travaux qui démontrent que les témoignages des aînés tendent à être moins détaillés que ceux produits par des témoins plus jeunes. L’entretien cognitif est une technique d’interrogatoire qui repose sur des stratégies de rappel issues des sciences cognitives. Plusieurs travaux récents démontrent l’efficacité de l’entretien cognitif auprès d’échantillons de jeunes adultes. Toutefois, la recherche portant sur l’utilisation de l’entretien cognitif auprès de témoins âgés est récente et en développement. Le présent article effectue une synthèse des travaux portant sur l’efficacité de l’entretien cognitif auprès d’aînés ainsi qu’une méta-analyse des données publiées à ce jour. La méta-analyse comprend sept études traitant des performances de participants aînés et comparant l’efficacité de l’entretien cognitif à celle obtenue en employant d’autres techniques de rappel. Les résultats démontrent une augmentation du nombre de détails corrects rappelés quand l’entretien cognitif est utilisé. Cependant, les données actuelles ne permettent pas de conclusion valide pour le nombre de détails incorrects ou sur l’exactitude du rappel. La discussion présente les forces et faiblesses des travaux publiés à ce jour de manière à favoriser le développement futur de ce domaine de recherche.